SEQUENCE LISTING

<110>   CHIRON SpA
<110>   THE INSTITUTE FOR GENOMIC RESEARCH

<120>   STREPTOCOCCUS PNEUMONIAE PROTEINS AND NUCLEIC ACIDS

<130>   P026926WO

<150>   GB-0107658.7
<151>   2001-03-27

<160>   4979

<170>   SeqWin99, version 1.03

<210>   1
<211>   300
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1
atgaaaatca aagagcaaac taggaaacta gctgcgggca gctcaaaaca ctgttttaag   60
gttgtagatg gaactgacga agtcagctca aaacactgtt ttaaggttgt ggatggaact   120
gacgaagtca gctcaaaaca ctgttttgag gttgtggata gaactgacga agtcagctca   180
aaacactgtt ttgaggttgt ggatagaact gacgaagtca gctcaaaaca ctgttttgag   240
gttgtggata gaactgacga agtcagtaac catatacggc aaggcgacgt tgacgtggtt   300

<210>   2
<211>   100
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   2
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Ser Ser Lys 
1               5                   10                  15      

His Cys Phe Lys Val Val Asp Gly Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Cys Phe Lys Val Val Asp Gly Thr Asp Glu Val Ser Ser Lys His Cys 
        35                  40                  45              

Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys Phe 
    50                  55                  60                  

Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys Phe Glu 
65                  70                  75                  80  

Val Val Asp Arg Thr Asp Glu Val Ser Asn His Ile Arg Gln Gly Asp 
                85                  90                  95      

Val Asp Val Val 
            100 

<210>   3
<211>   630
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3
atgacctcta tcacagcgat ttttttcgat ttggatggaa ccctcgttga tagttctatc   60
gggattcaca atgcctttac ctataccttt aaagagctgg gggtgcctag ccctgatgcc   120
aaaactattc gtggttttat gggaccacct ctcgaaagta gttttgcgac ctgcctgtcc   180
aaagaccaaa tttctgaagc cgtgcagata tatcgttctt actataaggc aaaaggcatc   240
tatgaagctc aactctttcc tcagattata gacttgcttg aggagttatc gagcagttat   300
ccactctaca tcaccacgac aaaggataca tctactgctc aagacatggc aaaaaacttg   360
gaaatccatc atttctttga tggcatttat ggttctagcc ctgaagcacc ccataaggca   420
gatgtcattc accaagcctt gcagacacat caactagcac cagaacaagc catcatcatc   480
ggagatacca agtttgatat gctgggagct cgagaaacag gtattcagaa attggccatc   540
acttggggat ttggagagca agcagatcta ctaaactatc aacctgatta tatcgctcac   600
aaacccttag aagttttggc gtattttcaa                                    630

<210>   4
<211>   210
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydrolase, haloacid dehalogenase-like family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902137 (e-119)

<400>   4
Met Thr Ser Ile Thr Ala Ile Phe Phe Asp Leu Asp Gly Thr Leu Val 
1               5                   10                  15      

Asp Ser Ser Ile Gly Ile His Asn Ala Phe Thr Tyr Thr Phe Lys Glu 
            20                  25                  30          

Leu Gly Val Pro Ser Pro Asp Ala Lys Thr Ile Arg Gly Phe Met Gly 
        35                  40                  45              

Pro Pro Leu Glu Ser Ser Phe Ala Thr Cys Leu Ser Lys Asp Gln Ile 
    50                  55                  60                  

Ser Glu Ala Val Gln Ile Tyr Arg Ser Tyr Tyr Lys Ala Lys Gly Ile 
65                  70                  75                  80  

Tyr Glu Ala Gln Leu Phe Pro Gln Ile Ile Asp Leu Leu Glu Glu Leu 
                85                  90                  95      

Ser Ser Ser Tyr Pro Leu Tyr Ile Thr Thr Thr Lys Asp Thr Ser Thr 
            100                 105                 110         

Ala Gln Asp Met Ala Lys Asn Leu Glu Ile His His Phe Phe Asp Gly 
        115                 120                 125             

Ile Tyr Gly Ser Ser Pro Glu Ala Pro His Lys Ala Asp Val Ile His 
    130                 135                 140                 

Gln Ala Leu Gln Thr His Gln Leu Ala Pro Glu Gln Ala Ile Ile Ile 
145                 150                 155                 160 

Gly Asp Thr Lys Phe Asp Met Leu Gly Ala Arg Glu Thr Gly Ile Gln 
                165                 170                 175     

Lys Leu Ala Ile Thr Trp Gly Phe Gly Glu Gln Ala Asp Leu Leu Asn 
            180                 185                 190         

Tyr Gln Pro Asp Tyr Ile Ala His Lys Pro Leu Glu Val Leu Ala Tyr 
        195                 200                 205             

Phe Gln 
    210 

<210>   5
<211>   870
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   5
atgttttatt ctatcaaaga attggtcgag caagcagatc tggactttca aggaaatgtc   60
gcagaactca tgattacaac agagtttgaa ttgaccggtc gcgaacgtga agaagtcttc   120
cttctcatgg aacgcaatct ggaagttatg aaagcctctg tccaacttgg cctcaatgaa   180
aataaatctc gtagtggcct gacaggtgga gatgctgcca aattggatca ctacatcgaa   240
aacggaaaaa ctctgtcaga ttatacgatt ctctcggctg cccgaaatgc catcgcagtc   300
aatgaacaca atgccaaaat gggcttggtc tgtgccactc caaccgctgg aagtgctggc   360
tgtctgccat ccgttctcac tgctgctatt gaaaaattag acctcagcca cgagcaacaa   420
ttggatttcc tctttgctgc tggtgccttt ggactagtca tcgcaaacaa tgcctccatc   480
tcaggtgctg agggtgggtg tcaagctgaa gttggttcag cctctgctat gagtgctgcc   540
gccttgactc tggctgcagg tggaacacct tatcaggcca gtcaagctat tgcctttgtc   600
attaaaaata tgctaggcct catctgtgac cctgttgcag gtttggtcga agttccctgt   660
gtcaaacgta atgccatggg agctagcttt gctttcatcg cagcagacat ggccttggca   720
ggtatcgaat ctaaaatccc tgtggatgaa gtgatcgatg ccatgtacca agtaggagca   780
agcatgccaa ctgcctttcg tgaaacagct gaaggtggac tcgctaccac ccctactggt   840
cgtcgcctcc aaaaagaaat tttcggagaa                                    870

<210>   6
<211>   290
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   L-serine dehydratase, iron-sulfur-dependent, alpha subunit (sdhA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902138 (e-161)

<400>   6
Met Phe Tyr Ser Ile Lys Glu Leu Val Glu Gln Ala Asp Leu Asp Phe 
1               5                   10                  15      

Gln Gly Asn Val Ala Glu Leu Met Ile Thr Thr Glu Phe Glu Leu Thr 
            20                  25                  30          

Gly Arg Glu Arg Glu Glu Val Phe Leu Leu Met Glu Arg Asn Leu Glu 
        35                  40                  45              

Val Met Lys Ala Ser Val Gln Leu Gly Leu Asn Glu Asn Lys Ser Arg 
    50                  55                  60                  

Ser Gly Leu Thr Gly Gly Asp Ala Ala Lys Leu Asp His Tyr Ile Glu 
65                  70                  75                  80  

Asn Gly Lys Thr Leu Ser Asp Tyr Thr Ile Leu Ser Ala Ala Arg Asn 
                85                  90                  95      

Ala Ile Ala Val Asn Glu His Asn Ala Lys Met Gly Leu Val Cys Ala 
            100                 105                 110         

Thr Pro Thr Ala Gly Ser Ala Gly Cys Leu Pro Ser Val Leu Thr Ala 
        115                 120                 125             

Ala Ile Glu Lys Leu Asp Leu Ser His Glu Gln Gln Leu Asp Phe Leu 
    130                 135                 140                 

Phe Ala Ala Gly Ala Phe Gly Leu Val Ile Ala Asn Asn Ala Ser Ile 
145                 150                 155                 160 

Ser Gly Ala Glu Gly Gly Cys Gln Ala Glu Val Gly Ser Ala Ser Ala 
                165                 170                 175     

Met Ser Ala Ala Ala Leu Thr Leu Ala Ala Gly Gly Thr Pro Tyr Gln 
            180                 185                 190         


Ala Ser Gln Ala Ile Ala Phe Val Ile Lys Asn Met Leu Gly Leu Ile 
        195                 200                 205             

Cys Asp Pro Val Ala Gly Leu Val Glu Val Pro Cys Val Lys Arg Asn 
    210                 215                 220                 

Ala Met Gly Ala Ser Phe Ala Phe Ile Ala Ala Asp Met Ala Leu Ala 
225                 230                 235                 240 

Gly Ile Glu Ser Lys Ile Pro Val Asp Glu Val Ile Asp Ala Met Tyr 
                245                 250                 255     

Gln Val Gly Ala Ser Met Pro Thr Ala Phe Arg Glu Thr Ala Glu Gly 
            260                 265                 270         

Gly Leu Ala Thr Thr Pro Thr Gly Arg Arg Leu Gln Lys Glu Ile Phe 
        275                 280                 285             

Gly Glu 
    290 

<210>   7
<211>   669
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   7
atgaaatcac ttcgttttca atctgtcttt gatatcatcg gaccagttat gattggccca   60
tctagtagcc ataccgctgg tgctgttcgt attgggaaga ttgtctcttc catttttgat   120
gatactccga cagaagttga attccaactt tttaactcat ttgccaagac ctatcgtggt   180
cacggaacag acctagccct tgttgcaggt attttaggaa tggatacaga tgatcctgaa   240
attccaaata gtctggaaat tgcccacaag cgtggtatca agattgtctg gaccattcag   300
aaagacagca atgcccctca ccctaacacc actaaaatta ctgttaaaaa tgcccacaag   360
accatcagcg tgactggtat ttctatcggt ggaggaaata ttcaggtaac cgaactcaat   420
ggttttgccg tctctctcaa tatgaataca ccgactatca tcatcgttca tcaagatatt   480
ccaggtatga ttgcccttgt tacagaggcg ctttcccgct atggtatcaa tatcgcccag   540
atgaatgtca ctcgtgaaaa agctggtgaa aaagccatta tgattatcga agttgacagt   600
cgcaactgtg atgaggctat cgaagaaatt cgaaaaatcc ctcatctcca caatgtcaat   660
ttctttaaa                                                           669

<210>   8
<211>   223
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   L-serine dehydratase, iron-sulfur-dependent, beta subunit (sdhB)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902139 (e-126)

<400>   8
Met Lys Ser Leu Arg Phe Gln Ser Val Phe Asp Ile Ile Gly Pro Val 
1               5                   10                  15      

Met Ile Gly Pro Ser Ser Ser His Thr Ala Gly Ala Val Arg Ile Gly 
            20                  25                  30          

Lys Ile Val Ser Ser Ile Phe Asp Asp Thr Pro Thr Glu Val Glu Phe 
        35                  40                  45              

Gln Leu Phe Asn Ser Phe Ala Lys Thr Tyr Arg Gly His Gly Thr Asp 
    50                  55                  60                  

Leu Ala Leu Val Ala Gly Ile Leu Gly Met Asp Thr Asp Asp Pro Glu 
65                  70                  75                  80  

Ile Pro Asn Ser Leu Glu Ile Ala His Lys Arg Gly Ile Lys Ile Val 
                85                  90                  95      

Trp Thr Ile Gln Lys Asp Ser Asn Ala Pro His Pro Asn Thr Thr Lys 
            100                 105                 110         

Ile Thr Val Lys Asn Ala His Lys Thr Ile Ser Val Thr Gly Ile Ser 
        115                 120                 125             

Ile Gly Gly Gly Asn Ile Gln Val Thr Glu Leu Asn Gly Phe Ala Val 
    130                 135                 140                 

Ser Leu Asn Met Asn Thr Pro Thr Ile Ile Ile Val His Gln Asp Ile 
145                 150                 155                 160 

Pro Gly Met Ile Ala Leu Val Thr Glu Ala Leu Ser Arg Tyr Gly Ile 
                165                 170                 175     

Asn Ile Ala Gln Met Asn Val Thr Arg Glu Lys Ala Gly Glu Lys Ala 
            180                 185                 190         

Ile Met Ile Ile Glu Val Asp Ser Arg Asn Cys Asp Glu Ala Ile Glu 
        195                 200                 205             

Glu Ile Arg Lys Ile Pro His Leu His Asn Val Asn Phe Phe Lys 
    210                 215                 220             

<210>   9
<211>   585
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   9
atgaaatcaa taactaaaaa gattaaagca actcttgcag gagtagctgc cttgtttgca   60
gtatttgctc catcatttgt atctgctcaa gaatcatcaa cttacactgt taaagaaggt   120
gatacacttt cagaaatcgc tgaaactcac aacacaacag ttgaaaaatt ggcagaaaac   180
aaccacattg ataacattca tttgatttat gttgatcaag agttggttat cgatggccct   240
gtagcgcctg ttgcaacacc agcgccagct acttatgcgg caccagccgc tcaagatgaa   300
actgtttcag ctccagtagc agaaactcca gtagtaagtg aaacagttgt ttcaactgta   360
agcggatctg aagcagaagc caaagaatgg atcgctcaaa aagaatcagg tggtagctat   420
acagctacaa atggacgtta tatcggacgt taccaattaa cagattcata cctgaacggt   480
gactactcag ctgaaaacca agaacgtgta gcagatgcct acgttgcagg acgttacggt   540
tcatggactg ctgctaaaaa cttctggctt aacaatggct ggtat                   585

<210>   10
<211>   195
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   LysM domain protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902140 (1.E-88)

<400>   10
Met Lys Ser Ile Thr Lys Lys Ile Lys Ala Thr Leu Ala Gly Val Ala 
1               5                   10                  15      

Ala Leu Phe Ala Val Phe Ala Pro Ser Phe Val Ser Ala Gln Glu Ser 
            20                  25                  30          

Ser Thr Tyr Thr Val Lys Glu Gly Asp Thr Leu Ser Glu Ile Ala Glu 
        35                  40                  45              

Thr His Asn Thr Thr Val Glu Lys Leu Ala Glu Asn Asn His Ile Asp 
    50                  55                  60                  

Asn Ile His Leu Ile Tyr Val Asp Gln Glu Leu Val Ile Asp Gly Pro 
65                  70                  75                  80  

Val Ala Pro Val Ala Thr Pro Ala Pro Ala Thr Tyr Ala Ala Pro Ala 
                85                  90                  95      

Ala Gln Asp Glu Thr Val Ser Ala Pro Val Ala Glu Thr Pro Val Val 
            100                 105                 110         

Ser Glu Thr Val Val Ser Thr Val Ser Gly Ser Glu Ala Glu Ala Lys 
        115                 120                 125             

Glu Trp Ile Ala Gln Lys Glu Ser Gly Gly Ser Tyr Thr Ala Thr Asn 
    130                 135                 140                 

Gly Arg Tyr Ile Gly Arg Tyr Gln Leu Thr Asp Ser Tyr Leu Asn Gly 
145                 150                 155                 160 

Asp Tyr Ser Ala Glu Asn Gln Glu Arg Val Ala Asp Ala Tyr Val Ala 
                165                 170                 175     

Gly Arg Tyr Gly Ser Trp Thr Ala Ala Lys Asn Phe Trp Leu Asn Asn 
            180                 185                 190         

Gly Trp Tyr 
        195 

<210>   11
<211>   318
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   11
ttgcaacgct tagaagtcta taaaaactat caacgtttat atgacttgcg aatagcaatc   60
ctgctcaacc tttccacact ctatctatac aatcaagata aaaacatgtg taagcaaatc   120
tgctatactt tactggagga cgccaagaat aagaaaagtt acgataggct ggctatctgc   180
tatgtcccta ttgggatttg tacagacgat tctaaactta tccaaaaagg gttctccctt   240
ctggagctaa ccgaggaaac ttctatgctg tctcatctca aaaaagaagt agagatctat   300
taccaagcga aggaaaga                                                 318

<210>   12
<211>   106
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902148 (3.E-55)

<400>   12
Met Gln Arg Leu Glu Val Tyr Lys Asn Tyr Gln Arg Leu Tyr Asp Leu 
1               5                   10                  15      

Arg Ile Ala Ile Leu Leu Asn Leu Ser Thr Leu Tyr Leu Tyr Asn Gln 
            20                  25                  30          

Asp Lys Asn Met Cys Lys Gln Ile Cys Tyr Thr Leu Leu Glu Asp Ala 
        35                  40                  45              

Lys Asn Lys Lys Ser Tyr Asp Arg Leu Ala Ile Cys Tyr Val Pro Ile 
    50                  55                  60                  

Gly Ile Cys Thr Asp Asp Ser Lys Leu Ile Gln Lys Gly Phe Ser Leu 
65                  70                  75                  80  

Leu Glu Leu Thr Glu Glu Thr Ser Met Leu Ser His Leu Lys Lys Glu 
                85                  90                  95      

Val Glu Ile Tyr Tyr Gln Ala Lys Glu Arg 
            100                 105     

<210>   13
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   13
atgagaaaat tagttaaaat tggtgttgca tctttaatgg tatgtggtat acttgctact   60
acaaatgctt tagcagtatg ggttgagggt ggtcaatgga actatggagt aggttggaca   120
ggaacttttg gatattctga ttacttacat tctactcgat atcatacagc aactgttaga   180
catgggggta gaacctctaa ggattatgca aaacctgagg catgggctag agcttccctc   240
accaagattc cgccaacagg aatggaatat ttctatggat ttgag                   285

<210>   14
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacteriocin, putative
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902142 (2.E-36)

<400>   14
Met Arg Lys Leu Val Lys Ile Gly Val Ala Ser Leu Met Val Cys Gly 
1               5                   10                  15      

Ile Leu Ala Thr Thr Asn Ala Leu Ala Val Trp Val Glu Gly Gly Gln 
            20                  25                  30          

Trp Asn Tyr Gly Val Gly Trp Thr Gly Thr Phe Gly Tyr Ser Asp Tyr 
        35                  40                  45              

Leu His Ser Thr Arg Tyr His Thr Ala Thr Val Arg His Gly Gly Arg 
    50                  55                  60                  

Thr Ser Lys Asp Tyr Ala Lys Pro Glu Ala Trp Ala Arg Ala Ser Leu 
65                  70                  75                  80  

Thr Lys Ile Pro Pro Thr Gly Met Glu Tyr Phe Tyr Gly Phe Glu 
                85                  90                  95  

<210>   15
<211>   213
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   15
ttggatattc tgattactta cattctactc gatatcatac agcaactgtt agacatgggg   60
gtagaacctc taaggattat gcaaaacctg aggcatgggc tagagcttcc ctcaccaaga   120
ttccgccaac aggaatggaa tatttctatg gatttgagta aaattcttcc ctctcctatt   180
tggagaggga aaactgtagt ggaggcactt tta                                213

<210>   16
<211>   71
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   16
Met Asp Ile Leu Ile Thr Tyr Ile Leu Leu Asp Ile Ile Gln Gln Leu 
1               5                   10                  15      

Leu Asp Met Gly Val Glu Pro Leu Arg Ile Met Gln Asn Leu Arg His 
            20                  25                  30          

Gly Leu Glu Leu Pro Ser Pro Arg Phe Arg Gln Gln Glu Trp Asn Ile 
        35                  40                  45              

Ser Met Asp Leu Ser Lys Ile Leu Pro Ser Pro Ile Trp Arg Gly Lys 
    50                  55                  60                  

Thr Val Val Glu Ala Leu Leu 
65                  70      

<210>   17
<211>   2082
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   17
atgttactcc tgcttctgtg taccactttt tttgttttta atgtaaacta tacacgagaa   60
gtggttcgga ttcaagaaat gggaaagact gtagattctt tggatttgta tttgaaagat   120
attaacgaac ctgcagcgtc tgttcttcga ttttttgagg atgtatcaaa ggagtataaa   180
gtctccatca tcaaaacaga cagtggtgat gaggtggtca agtctggtgt ttttgataaa   240
gataccttcc cctaccaaga gtttgggatt tcttctcttg attttaccac agatggtgaa   300
ggagtctata gtaataaaga aatttccaat aaacttggta cgattccgac ctttctaaaa   360
gccaaaccta ttcagcttat gacttttcaa acctatatca aggatacatc tcgtagttta   420
aatggtcgct atacgataac ttctacacaa gagatggaca aggataggat tgtacagaaa   480
tggagcgatt ttttcaagat agaccaggct accttgctag agccgaccta caaaagtgca   540
gtggaagtca taaatcgaga tttgctttta tctgccattg tttttgtctt ggctattttg   600
cttcttgtgt tagtgacagt gtatcaaccg atgatggaga tgaaaagagt tggggtacaa   660
aaattacttg gttttcaaga tagggctgtt ttagctgatg ttgtaaaagg caacctttac   720
ctcctcctag gtggggctct tgtgatcaat ctaggcgtgt ttttcttgct tgattataag   780
ccaaaagatt tgtttcctat gctgtggttg tctcattttt tgctgttgca gctttatctc   840
tttatcagtt ggttgactta cctcttaatc caaaaaatga caatcagctc tctgctgaaa   900
ggtttttcat ctttcaaatt tggtcttatc ttcaattatg tgatgaaaat agggacaact   960
attttactga cggccttact gattggggtg ggcagaagtt tagaacaaga aaacaaagaa   1020
cttgcttatc agcaacagtg ggtaagtcaa ggtaattacc tgaccttaga aaccttcaaa   1080
ctcaatgata atctgtggca agaagagcta gcagggtcag ggaaatctac agattatttc   1140
tatcgatttt atcaggattt ggtagaaaaa acgcaggcgg gctatgtgca gagtagcagt   1200
cttcctgtaa aaaattttgt ccaatcagaa cagattcagc aatatcagtt aacagatacg   1260
gtggatgttt actatgccaa tcgcaatttt ctaaagagca agggattcaa gctaccaaat   1320
accggtatta aaaaagttat tttgatgcca gcaagtacga aaggtgaaga agataaaaat   1380
cagctcttgg ggaagttaat tgcctttcat tcgatgaagt atgaagagca gcaaaaacga   1440
acgatagagg agatggatgt cgagattgcc tattatgaag gagattggtc atttttccca   1500
tatagtgata agcgaaagga aaatctctcc aatccaatta ttagcttggt caatgattct   1560
gatatgatgt gggatgagaa agcctccctg tcaacaactg gcttaaataa tccgattaaa   1620
attgaaaata cggttcaaca tcaaaaagag attacagagt tagttgagaa attgtcagat   1680
ggaaattatt taaaattttc atctattcaa gccattcaac aagagaaagt ggattcttat   1740
cgagatgctg ttcggaattt taacctactc tttgctttgt ttggtctcct tagcatgatg   1800
atttcctact tcttactagt aacaactttc ttattgaagc gcagggatat cattaccaag   1860
aagtttatgg ggtggaaact ggtcgatcgc taccgtcctc tcctcgttct gctcttgctg   1920
ggctatagtt tccctcttct agtcttgatt ttctttgccc atgcgttctt accacttcta   1980
ctgtttgcag gttttacatg tctggatata ctatttgtgc taggcttagc ttctaggatg   2040
gagaaaagaa gtctagtaga gttattgaaa gggggcatct ta                      2082

<210>   18
<211>   694
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (ABC transporter)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902143 (0.E+01)

<400>   18
Met Leu Leu Leu Leu Leu Cys Thr Thr Phe Phe Val Phe Asn Val Asn 
1               5                   10                  15      

Tyr Thr Arg Glu Val Val Arg Ile Gln Glu Met Gly Lys Thr Val Asp 
            20                  25                  30          

Ser Leu Asp Leu Tyr Leu Lys Asp Ile Asn Glu Pro Ala Ala Ser Val 
        35                  40                  45              

Leu Arg Phe Phe Glu Asp Val Ser Lys Glu Tyr Lys Val Ser Ile Ile 
    50                  55                  60                  

Lys Thr Asp Ser Gly Asp Glu Val Val Lys Ser Gly Val Phe Asp Lys 
65                  70                  75                  80  

Asp Thr Phe Pro Tyr Gln Glu Phe Gly Ile Ser Ser Leu Asp Phe Thr 
                85                  90                  95      

Thr Asp Gly Glu Gly Val Tyr Ser Asn Lys Glu Ile Ser Asn Lys Leu 
            100                 105                 110         

Gly Thr Ile Pro Thr Phe Leu Lys Ala Lys Pro Ile Gln Leu Met Thr 
        115                 120                 125             

Phe Gln Thr Tyr Ile Lys Asp Thr Ser Arg Ser Leu Asn Gly Arg Tyr 
    130                 135                 140                 

Thr Ile Thr Ser Thr Gln Glu Met Asp Lys Asp Arg Ile Val Gln Lys 
145                 150                 155                 160 

Trp Ser Asp Phe Phe Lys Ile Asp Gln Ala Thr Leu Leu Glu Pro Thr 
                165                 170                 175     

Tyr Lys Ser Ala Val Glu Val Ile Asn Arg Asp Leu Leu Leu Ser Ala 
            180                 185                 190         

Ile Val Phe Val Leu Ala Ile Leu Leu Leu Val Leu Val Thr Val Tyr 
        195                 200                 205             

Gln Pro Met Met Glu Met Lys Arg Val Gly Val Gln Lys Leu Leu Gly 
    210                 215                 220                 

Phe Gln Asp Arg Ala Val Leu Ala Asp Val Val Lys Gly Asn Leu Tyr 
225                 230                 235                 240 

Leu Leu Leu Gly Gly Ala Leu Val Ile Asn Leu Gly Val Phe Phe Leu 
                245                 250                 255     

Leu Asp Tyr Lys Pro Lys Asp Leu Phe Pro Met Leu Trp Leu Ser His 
            260                 265                 270         

Phe Leu Leu Leu Gln Leu Tyr Leu Phe Ile Ser Trp Leu Thr Tyr Leu 
        275                 280                 285             

Leu Ile Gln Lys Met Thr Ile Ser Ser Leu Leu Lys Gly Phe Ser Ser 
    290                 295                 300                 

Phe Lys Phe Gly Leu Ile Phe Asn Tyr Val Met Lys Ile Gly Thr Thr 
305                 310                 315                 320 

Ile Leu Leu Thr Ala Leu Leu Ile Gly Val Gly Arg Ser Leu Glu Gln 
                325                 330                 335     

Glu Asn Lys Glu Leu Ala Tyr Gln Gln Gln Trp Val Ser Gln Gly Asn 
            340                 345                 350         

Tyr Leu Thr Leu Glu Thr Phe Lys Leu Asn Asp Asn Leu Trp Gln Glu 
        355                 360                 365             

Glu Leu Ala Gly Ser Gly Lys Ser Thr Asp Tyr Phe Tyr Arg Phe Tyr 
    370                 375                 380                 

Gln Asp Leu Val Glu Lys Thr Gln Ala Gly Tyr Val Gln Ser Ser Ser 
385                 390                 395                 400 

Leu Pro Val Lys Asn Phe Val Gln Ser Glu Gln Ile Gln Gln Tyr Gln 
                405                 410                 415     

Leu Thr Asp Thr Val Asp Val Tyr Tyr Ala Asn Arg Asn Phe Leu Lys 
            420                 425                 430         

Ser Lys Gly Phe Lys Leu Pro Asn Thr Gly Ile Lys Lys Val Ile Leu 
        435                 440                 445             

Met Pro Ala Ser Thr Lys Gly Glu Glu Asp Lys Asn Gln Leu Leu Gly 
    450                 455                 460                 

Lys Leu Ile Ala Phe His Ser Met Lys Tyr Glu Glu Gln Gln Lys Arg 

465                 470                 475                 480 

Thr Ile Glu Glu Met Asp Val Glu Ile Ala Tyr Tyr Glu Gly Asp Trp 
                485                 490                 495     

Ser Phe Phe Pro Tyr Ser Asp Lys Arg Lys Glu Asn Leu Ser Asn Pro 
            500                 505                 510         

Ile Ile Ser Leu Val Asn Asp Ser Asp Met Met Trp Asp Glu Lys Ala 
        515                 520                 525             

Ser Leu Ser Thr Thr Gly Leu Asn Asn Pro Ile Lys Ile Glu Asn Thr 
    530                 535                 540                 

Val Gln His Gln Lys Glu Ile Thr Glu Leu Val Glu Lys Leu Ser Asp 
545                 550                 555                 560 

Gly Asn Tyr Leu Lys Phe Ser Ser Ile Gln Ala Ile Gln Gln Glu Lys 
                565                 570                 575     

Val Asp Ser Tyr Arg Asp Ala Val Arg Asn Phe Asn Leu Leu Phe Ala 
            580                 585                 590         

Leu Phe Gly Leu Leu Ser Met Met Ile Ser Tyr Phe Leu Leu Val Thr 
        595                 600                 605             

Thr Phe Leu Leu Lys Arg Arg Asp Ile Ile Thr Lys Lys Phe Met Gly 
    610                 615                 620                 

Trp Lys Leu Val Asp Arg Tyr Arg Pro Leu Leu Val Leu Leu Leu Leu 
625                 630                 635                 640 

Gly Tyr Ser Phe Pro Leu Leu Val Leu Ile Phe Phe Ala His Ala Phe 
                645                 650                 655     

Leu Pro Leu Leu Leu Phe Ala Gly Phe Thr Cys Leu Asp Ile Leu Phe 
            660                 665                 670         

Val Leu Gly Leu Ala Ser Arg Met Glu Lys Arg Ser Leu Val Glu Leu 
        675                 680                 685             

Leu Lys Gly Gly Ile Leu 
    690                 

<210>   19
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   19
atgattgagt tgaaaaatat taccaaaacc attgggggaa aagtgatttt ggataactta   60
tctctcagga ttgatcaggg ggatttggta gctattgttg gtaagagtgg tagtgggaag   120
tcgaccttgt taaatttatt gggtttgata gatggtgatt atagcggacg gtatgagatt   180
tttggtcaga caaatctagc ggttaattct gctaagtcgc aaacaataat ccgtgaacat   240
atctcttatc tgtttcaaaa ttttgccctg attgatgatg aaacggtcga gtacaatctc   300
atgctggcgc tgaaatatgt gaaattgcct aagaaagaca agctcaaaaa ggtggaagag   360
attttagaga gagtaggttt atcagctact ttgcatcaaa gggtctccga gttgtctggg   420
ggcgaacaac aacgaattgc agttgctaga gccatcttaa aacccagcca gctgatttta   480
gccgatgaac cgacaggttc tctggatcct gaaaatagag atttggtctt gaagtttctc   540
ttagagatga atcgagaggg gaaaacagtc attatcgtga cccacgatgc ttatgtagcc   600
caacaatgtc atcgaatcat tgaattaggc gagggaaaa                          639

<210>   20
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, ATP-binding protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902144 (e-116)

<400>   20
Met Ile Glu Leu Lys Asn Ile Thr Lys Thr Ile Gly Gly Lys Val Ile 
1               5                   10                  15      

Leu Asp Asn Leu Ser Leu Arg Ile Asp Gln Gly Asp Leu Val Ala Ile 
            20                  25                  30          

Val Gly Lys Ser Gly Ser Gly Lys Ser Thr Leu Leu Asn Leu Leu Gly 
        35                  40                  45              

Leu Ile Asp Gly Asp Tyr Ser Gly Arg Tyr Glu Ile Phe Gly Gln Thr 
    50                  55                  60                  

Asn Leu Ala Val Asn Ser Ala Lys Ser Gln Thr Ile Ile Arg Glu His 
65                  70                  75                  80  


Ile Ser Tyr Leu Phe Gln Asn Phe Ala Leu Ile Asp Asp Glu Thr Val 
                85                  90                  95      

Glu Tyr Asn Leu Met Leu Ala Leu Lys Tyr Val Lys Leu Pro Lys Lys 
            100                 105                 110         

Asp Lys Leu Lys Lys Val Glu Glu Ile Leu Glu Arg Val Gly Leu Ser 
        115                 120                 125             

Ala Thr Leu His Gln Arg Val Ser Glu Leu Ser Gly Gly Glu Gln Gln 
    130                 135                 140                 

Arg Ile Ala Val Ala Arg Ala Ile Leu Lys Pro Ser Gln Leu Ile Leu 
145                 150                 155                 160 

Ala Asp Glu Pro Thr Gly Ser Leu Asp Pro Glu Asn Arg Asp Leu Val 
                165                 170                 175     

Leu Lys Phe Leu Leu Glu Met Asn Arg Glu Gly Lys Thr Val Ile Ile 
            180                 185                 190         

Val Thr His Asp Ala Tyr Val Ala Gln Gln Cys His Arg Ile Ile Glu 
        195                 200                 205             

Leu Gly Glu Gly Lys 
    210             

<210>   21
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   21
ttgacaaagg atgcatatag atgtattgtt tatacaaata aaaggaataa acataaagta   60
ggctttatta tgaataagat gaagaaggtg ttgatgacga tgtttggttt agtgatgctc   120
cccctactat ttgcttgtag caacaatcaa tcggctggaa ttgaagccat caagtccaaa   180
ggaaaattgg ttgtagccct caatccggat tttgctccat ttgaatacca aaaagtggtt   240
gatgggaaaa atcagattgt gggttcagat atcgaattag ccaaggctat cgcaacaaaa   300
ctaggtgtcg aattggaact atctcccatg agttttgata atgtactggc tagtgttcaa   360
tcaggaaaag ccgaccttgc catatcaggt gtttctaaga cagatgaacg gagcaaggtg   420
tttgactttt ccattcccta ctatactgca aaaaataaac tcattgtcaa aaaatctgac   480
ttgactactt atcagtctgt aaacgacttg gcgcagaaaa aggttggagc gcagaaaggt   540
tcgattcaag agacgatggc gaaagatttg ctacaaaatt cttccctcgt atctctgcct   600
aaaaatggga atttaatcac agatttaaaa tcaggacaag tggatgccgt tatctttgaa   660
gaacctgttt ccaagggatt tgtggaaaat aatcctgatt tagcaatcgc agacctcaat   720
tttgaaaaag agcaagatga ttcctacgcg gtagccatga aaaaagatag caagaaattg   780
aaagaggcag tcgataaaac cattcaaaag ttgaaggagt ctggggaatt agacaaactc   840
attgaggatg cctttaaagc atccattgaa aaa                                873

<210>   22
<211>   291
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, periplasmic amino acid-binding protein, put
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902145 (e-142)

<400>   22
Met Thr Lys Asp Ala Tyr Arg Cys Ile Val Tyr Thr Asn Lys Arg Asn 
1               5                   10                  15      

Lys His Lys Val Gly Phe Ile Met Asn Lys Met Lys Lys Val Leu Met 
            20                  25                  30          

Thr Met Phe Gly Leu Val Met Leu Pro Leu Leu Phe Ala Cys Ser Asn 
        35                  40                  45              

Asn Gln Ser Ala Gly Ile Glu Ala Ile Lys Ser Lys Gly Lys Leu Val 
    50                  55                  60                  

Val Ala Leu Asn Pro Asp Phe Ala Pro Phe Glu Tyr Gln Lys Val Val 
65                  70                  75                  80  

Asp Gly Lys Asn Gln Ile Val Gly Ser Asp Ile Glu Leu Ala Lys Ala 
                85                  90                  95      

Ile Ala Thr Lys Leu Gly Val Glu Leu Glu Leu Ser Pro Met Ser Phe 
            100                 105                 110         

Asp Asn Val Leu Ala Ser Val Gln Ser Gly Lys Ala Asp Leu Ala Ile 
        115                 120                 125             

Ser Gly Val Ser Lys Thr Asp Glu Arg Ser Lys Val Phe Asp Phe Ser 
    130                 135                 140                 

Ile Pro Tyr Tyr Thr Ala Lys Asn Lys Leu Ile Val Lys Lys Ser Asp 
145                 150                 155                 160 

Leu Thr Thr Tyr Gln Ser Val Asn Asp Leu Ala Gln Lys Lys Val Gly 
                165                 170                 175     

Ala Gln Lys Gly Ser Ile Gln Glu Thr Met Ala Lys Asp Leu Leu Gln 
            180                 185                 190         

Asn Ser Ser Leu Val Ser Leu Pro Lys Asn Gly Asn Leu Ile Thr Asp 
        195                 200                 205             

Leu Lys Ser Gly Gln Val Asp Ala Val Ile Phe Glu Glu Pro Val Ser 
    210                 215                 220                 


Lys Gly Phe Val Glu Asn Asn Pro Asp Leu Ala Ile Ala Asp Leu Asn 
225                 230                 235                 240 

Phe Glu Lys Glu Gln Asp Asp Ser Tyr Ala Val Ala Met Lys Lys Asp 
                245                 250                 255     

Ser Lys Lys Leu Lys Glu Ala Val Asp Lys Thr Ile Gln Lys Leu Lys 
            260                 265                 270         

Glu Ser Gly Glu Leu Asp Lys Leu Ile Glu Asp Ala Phe Lys Ala Ser 
        275                 280                 285             

Ile Glu Lys 
    290     

<210>   23
<211>   417
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   23
atgagtaaag aaaaagtaat tttggcctat tctggcggtt tggacacatc agttgctatt   60
acctggttaa agaaagacta tgatgttgtt tcagtttgta tggatgtggg tgaagggaaa   120
gacttagatt tcatccatga taaggctctt aaggtttggg cagtagaatc ttatgtcatt   180
gatgttaagg acgaatttgc tacagattat gtgctagtgg ctcatcagtc acatgcctat   240
tatgaacaaa agtatctctt ggtatctgcc ttgagccgcc ctctgatttc taaaaaattg   300
gttgaaatag cgcatcagat aggagcgact acaattgctc atggttgtac cggtaagggg   360
aatgaccaag tcgaatacca gattgcagtc gctaagaaag cgaatgaagc taaaaag      417

<210>   24
<211>   139
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   argininosuccinate synthase, truncation (argG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902146 (1.E-67)

<400>   24
Met Ser Lys Glu Lys Val Ile Leu Ala Tyr Ser Gly Gly Leu Asp Thr 
1               5                   10                  15      

Ser Val Ala Ile Thr Trp Leu Lys Lys Asp Tyr Asp Val Val Ser Val 
            20                  25                  30          

Cys Met Asp Val Gly Glu Gly Lys Asp Leu Asp Phe Ile His Asp Lys 
        35                  40                  45              

Ala Leu Lys Val Trp Ala Val Glu Ser Tyr Val Ile Asp Val Lys Asp 
    50                  55                  60                  

Glu Phe Ala Thr Asp Tyr Val Leu Val Ala His Gln Ser His Ala Tyr 
65                  70                  75                  80  

Tyr Glu Gln Lys Tyr Leu Leu Val Ser Ala Leu Ser Arg Pro Leu Ile 
                85                  90                  95      

Ser Lys Lys Leu Val Glu Ile Ala His Gln Ile Gly Ala Thr Thr Ile 
            100                 105                 110         

Ala His Gly Cys Thr Gly Lys Gly Asn Asp Gln Val Glu Tyr Gln Ile 
        115                 120                 125             

Ala Val Ala Lys Lys Ala Asn Glu Ala Lys Lys 
    130                 135                 

<210>   25
<211>   318
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   25
ttgcaacgct tagaagtcta taaaaactat caacatttat atgacttgcg aatagcaatc   60
ctgctaaacc tttccacact ctatctatac aatcaagata aaaacatgtg taagcaaatc   120
tgctacactt tactggagga cgccaagaat aagaaaagct acgataggct tgctatctgc   180
tatgtccgta ttgggatttg tacagacgat tctaaactta tccaaaaagg gttctccctt   240
ctggagctga ccgaggaaac ttctatgctg tctcatctca aaaaagaagt agagacccat   300
tatcaaccaa agaaatta                                                 318

<210>   26
<211>   106
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902148 (4.E-54)

<400>   26
Met Gln Arg Leu Glu Val Tyr Lys Asn Tyr Gln His Leu Tyr Asp Leu 
1               5                   10                  15      

Arg Ile Ala Ile Leu Leu Asn Leu Ser Thr Leu Tyr Leu Tyr Asn Gln 
            20                  25                  30          

Asp Lys Asn Met Cys Lys Gln Ile Cys Tyr Thr Leu Leu Glu Asp Ala 
        35                  40                  45              

Lys Asn Lys Lys Ser Tyr Asp Arg Leu Ala Ile Cys Tyr Val Arg Ile 
    50                  55                  60                  

Gly Ile Cys Thr Asp Asp Ser Lys Leu Ile Gln Lys Gly Phe Ser Leu 
65                  70                  75                  80  

Leu Glu Leu Thr Glu Glu Thr Ser Met Leu Ser His Leu Lys Lys Glu 
                85                  90                  95      

Val Glu Thr His Tyr Gln Pro Lys Lys Leu 
            100                 105     

<210>   27
<211>   378
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   27
atggaactcg tattaccaaa taattatgtt gctcttgagc aagaagagat gatgtatctt   60
gatgggggtg gtgttggtcg taactggtgg aatagtagag gtagttttgc aacagttctg   120
gatgtagatt tggccatcta tagtggtggt gcaacaattt attctgctta tgcgataaaa   180
aaagctatct cagctaatag aggggctatt acgagaacat tacgtagttt aataattaaa   240
catgtaggta gtgcagctgg ccatttagtc aatactgcac taaacgttgc actaactgtt   300
actggatttt cactaggtgg agcaatcgca tatggggctg attgggctga cggtagctta   360
gatggttata tttttgct                                                 378

<210>   28
<211>   126
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902153 (1.E-67)

<400>   28
Met Glu Leu Val Leu Pro Asn Asn Tyr Val Ala Leu Glu Gln Glu Glu 
1               5                   10                  15      

Met Met Tyr Leu Asp Gly Gly Gly Val Gly Arg Asn Trp Trp Asn Ser 
            20                  25                  30          

Arg Gly Ser Phe Ala Thr Val Leu Asp Val Asp Leu Ala Ile Tyr Ser 
        35                  40                  45              

Gly Gly Ala Thr Ile Tyr Ser Ala Tyr Ala Ile Lys Lys Ala Ile Ser 
    50                  55                  60                  

Ala Asn Arg Gly Ala Ile Thr Arg Thr Leu Arg Ser Leu Ile Ile Lys 
65                  70                  75                  80  

His Val Gly Ser Ala Ala Gly His Leu Val Asn Thr Ala Leu Asn Val 
                85                  90                  95      

Ala Leu Thr Val Thr Gly Phe Ser Leu Gly Gly Ala Ile Ala Tyr Gly 
            100                 105                 110         

Ala Asp Trp Ala Asp Gly Ser Leu Asp Gly Tyr Ile Phe Ala 
        115                 120                 125     

<210>   29
<211>   243
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   29
ttgtcgttga aattacttga ttgtattttg gattatcaag aaagattcaa tggaaaaaca   60
tgtcaagtat caacgaatta taagtattta gagattttca aagtgaattt ttgcttgact   120
gatttacatc atttatttga cttacacaaa atcacacgag attatgctag tcaaacaaaa   180
cctgctattc aagatggtgt ttttatttta gaagatttta gaaatatcct atgtacaatg   240
atg                                                                 243

<210>   30
<211>   81
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902164 (2.E-42)

<400>   30
Met Ser Leu Lys Leu Leu Asp Cys Ile Leu Asp Tyr Gln Glu Arg Phe 
1               5                   10                  15      

Asn Gly Lys Thr Cys Gln Val Ser Thr Asn Tyr Lys Tyr Leu Glu Ile 
            20                  25                  30          

Phe Lys Val Asn Phe Cys Leu Thr Asp Leu His His Leu Phe Asp Leu 
        35                  40                  45              

His Lys Ile Thr Arg Asp Tyr Ala Ser Gln Thr Lys Pro Ala Ile Gln 
    50                  55                  60                  

Asp Gly Val Phe Ile Leu Glu Asp Phe Arg Asn Ile Leu Cys Thr Met 
65                  70                  75                  80  

Met 
    

<210>   31
<211>   2232
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   31
atgaataaga aaaaaatgat tttaacaagt ctagccagcg tcgctatctt aggggctggt   60
tttgttacgt ctcagcctac ttttgtaaga gcagaagaat ctccacaagt tgtcgaaaaa   120
tcttcattag agaagaaata tgaggaagca aaagcaaaag ctgatactgc caagaaagat   180
tacgaaacgg ctaaaaagaa agcagaagac gctcagaaaa agtatgaaga tgatcagaag   240
agaactgagg agaaagctcg aaaagaagca gaagcatctc aaaaattgaa tgatgtggcg   300
cttgttgttc aaaatgcata taaagagtac cgagaagttc aaaatcaacg tagtaaatat   360
aaatctgacg ctgaatatca gaaaaaatta acagaggtcg actctaaaat agagaaggct   420
aggaaagagc aacaggactt gcaaaataaa tttaatgaag taagagcagt tgtagttcct   480
gaaccaaatg cgttggctga gactaagaaa aaagcagaag aagctaaagc agaagaaaaa   540
gtagctaaga gaaaatatga ttatgcaact ctaaaggtag cactagcgaa gaaagaagta   600
gaggctaagg aacttgaaat tgaaaaactt caatatgaaa tttctacttt ggaacaagaa   660
gttgctactg ctcaacatca agtagataat ttgaaaaaac ttcttgctgg tgcggatcct   720
gatgatggca cagaagttat agaagctaaa ttaaaaaaag gagaagctga gctaaacgct   780
aaacaagctg agttagcaaa aaaacaaaca gaacttgaaa aacttcttga cagccttgat   840
cctgaaggta agactcagga tgaattagat aaagaagcag aagaagctga gttggataaa   900
aaagctgatg aacttcaaaa taaagttgct gatttagaaa aagaaattag taaccttgaa   960
atattacttg gaggggctga tcctgaagat gatactgctg ctcttcaaaa taaattagct   1020
gctaaaaaag ctgagttagc aaaaaaacaa acagaacttg aaaaacttct tgacagcctt   1080
gatcctgaag gtaagactca ggatgaatta gataaagaag cagaagaagc tgagttggat   1140
aaaaaagctg atgaacttca aaataaagtt gctgatttag aaaaagaaat tagtaacctt   1200
gaaatattac ttggaggggc tgattctgaa gatgatactg ctgctcttca aaataaatta   1260
gctactaaaa aagctgaatt ggaaaaaact caaaaagaat tagatgcagc tcttaatgag   1320
ttaggccctg atggagatga agaagaaact ccagcgccgg ctcctcaacc agagcaacca   1380
gctcctgcac caaaaccaga gcaaccagct ccagctccaa aaccagagca accagctcct   1440
gcaccaaaac cagagcaacc agctccagct ccaaaaccag agcaaccagc tccagctcca   1500
aaaccagagc aaccagctaa gccggagaaa ccagctgaag agcctactca accagaaaaa   1560
ccagccactc caaaaacagg ctggaaacaa gaaaacggta tgtggtattt ctacaatact   1620
gatggttcaa tggcaatagg ttggctccaa aacaacggtt catggtacta cctaaacgct   1680
aacggcgcta tggcaacagg ttgggtgaaa gatggagata cctggtacta tcttgaagca   1740
tcaggtgcta tgaaagcaag ccaatggttc aaagtatcag ataaatggta ctatgtcaac   1800
agcaatggcg ctatggcgac aggctggctc caatacaatg gctcatggta ctacctcaac   1860
gctaatggtg atatggcgac aggatggctc caatacaacg gttcatggta ttacctcaac   1920
gctaatggtg atatggcgac aggatgggct aaagtcaacg gttcatggta ctacctaaac   1980
gctaacggtg ctatggctac aggttgggct aaagtcaacg gttcatggta ctacctaaac   2040
gctaacggtt caatggcaac aggttgggtg aaagatggag atacctggta ctatcttgaa   2100
gcatcaggtg ctatgaaagc aagccaatgg ttcaaagtat cagataaatg gtactatgtc   2160
aatggcttag gtgcccttgc agtcaacaca actgtagatg gctataaagt caatgccaat   2220
ggtgaatggg tt                                                       2232

<210>   32
<211>   744
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pneumococcal surface protein A (pspA)
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15902165 (e-179)

<400>   32
Met Asn Lys Lys Lys Met Ile Leu Thr Ser Leu Ala Ser Val Ala Ile 
1               5                   10                  15      

Leu Gly Ala Gly Phe Val Thr Ser Gln Pro Thr Phe Val Arg Ala Glu 
            20                  25                  30          

Glu Ser Pro Gln Val Val Glu Lys Ser Ser Leu Glu Lys Lys Tyr Glu 
        35                  40                  45              

Glu Ala Lys Ala Lys Ala Asp Thr Ala Lys Lys Asp Tyr Glu Thr Ala 
    50                  55                  60                  

Lys Lys Lys Ala Glu Asp Ala Gln Lys Lys Tyr Glu Asp Asp Gln Lys 
65                  70                  75                  80  

Arg Thr Glu Glu Lys Ala Arg Lys Glu Ala Glu Ala Ser Gln Lys Leu 
                85                  90                  95      

Asn Asp Val Ala Leu Val Val Gln Asn Ala Tyr Lys Glu Tyr Arg Glu 
            100                 105                 110         

Val Gln Asn Gln Arg Ser Lys Tyr Lys Ser Asp Ala Glu Tyr Gln Lys 
        115                 120                 125             

Lys Leu Thr Glu Val Asp Ser Lys Ile Glu Lys Ala Arg Lys Glu Gln 
    130                 135                 140                 

Gln Asp Leu Gln Asn Lys Phe Asn Glu Val Arg Ala Val Val Val Pro 
145                 150                 155                 160 

Glu Pro Asn Ala Leu Ala Glu Thr Lys Lys Lys Ala Glu Glu Ala Lys 
                165                 170                 175     

Ala Glu Glu Lys Val Ala Lys Arg Lys Tyr Asp Tyr Ala Thr Leu Lys 
            180                 185                 190         

Val Ala Leu Ala Lys Lys Glu Val Glu Ala Lys Glu Leu Glu Ile Glu 
        195                 200                 205             

Lys Leu Gln Tyr Glu Ile Ser Thr Leu Glu Gln Glu Val Ala Thr Ala 
    210                 215                 220                 

Gln His Gln Val Asp Asn Leu Lys Lys Leu Leu Ala Gly Ala Asp Pro 
225                 230                 235                 240 

Asp Asp Gly Thr Glu Val Ile Glu Ala Lys Leu Lys Lys Gly Glu Ala 
                245                 250                 255     

Glu Leu Asn Ala Lys Gln Ala Glu Leu Ala Lys Lys Gln Thr Glu Leu 
            260                 265                 270         

Glu Lys Leu Leu Asp Ser Leu Asp Pro Glu Gly Lys Thr Gln Asp Glu 
        275                 280                 285             

Leu Asp Lys Glu Ala Glu Glu Ala Glu Leu Asp Lys Lys Ala Asp Glu 
    290                 295                 300                 

Leu Gln Asn Lys Val Ala Asp Leu Glu Lys Glu Ile Ser Asn Leu Glu 
305                 310                 315                 320 

Ile Leu Leu Gly Gly Ala Asp Pro Glu Asp Asp Thr Ala Ala Leu Gln 
                325                 330                 335     

Asn Lys Leu Ala Ala Lys Lys Ala Glu Leu Ala Lys Lys Gln Thr Glu 
            340                 345                 350         

Leu Glu Lys Leu Leu Asp Ser Leu Asp Pro Glu Gly Lys Thr Gln Asp 
        355                 360                 365             

Glu Leu Asp Lys Glu Ala Glu Glu Ala Glu Leu Asp Lys Lys Ala Asp 
    370                 375                 380                 

Glu Leu Gln Asn Lys Val Ala Asp Leu Glu Lys Glu Ile Ser Asn Leu 
385                 390                 395                 400 

Glu Ile Leu Leu Gly Gly Ala Asp Ser Glu Asp Asp Thr Ala Ala Leu 
                405                 410                 415     

Gln Asn Lys Leu Ala Thr Lys Lys Ala Glu Leu Glu Lys Thr Gln Lys 
            420                 425                 430         

Glu Leu Asp Ala Ala Leu Asn Glu Leu Gly Pro Asp Gly Asp Glu Glu 
        435                 440                 445             

Glu Thr Pro Ala Pro Ala Pro Gln Pro Glu Gln Pro Ala Pro Ala Pro 
    450                 455                 460                 

Lys Pro Glu Gln Pro Ala Pro Ala Pro Lys Pro Glu Gln Pro Ala Pro 
465                 470                 475                 480 

Ala Pro Lys Pro Glu Gln Pro Ala Pro Ala Pro Lys Pro Glu Gln Pro 
                485                 490                 495     

Ala Pro Ala Pro Lys Pro Glu Gln Pro Ala Lys Pro Glu Lys Pro Ala 
            500                 505                 510         

Glu Glu Pro Thr Gln Pro Glu Lys Pro Ala Thr Pro Lys Thr Gly Trp 
        515                 520                 525             

Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn Thr Asp Gly Ser Met 
    530                 535                 540                 

Ala Ile Gly Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala 
545                 550                 555                 560 

Asn Gly Ala Met Ala Thr Gly Trp Val Lys Asp Gly Asp Thr Trp Tyr 
                565                 570                 575     

Tyr Leu Glu Ala Ser Gly Ala Met Lys Ala Ser Gln Trp Phe Lys Val 
            580                 585                 590         

Ser Asp Lys Trp Tyr Tyr Val Asn Ser Asn Gly Ala Met Ala Thr Gly 
        595                 600                 605             

Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Asp 
    610                 615                 620                 

Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 
625                 630                 635                 640 

Ala Asn Gly Asp Met Ala Thr Gly Trp Ala Lys Val Asn Gly Ser Trp 
                645                 650                 655     

Tyr Tyr Leu Asn Ala Asn Gly Ala Met Ala Thr Gly Trp Ala Lys Val 
            660                 665                 670         

Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 
        675                 680                 685             

Trp Val Lys Asp Gly Asp Thr Trp Tyr Tyr Leu Glu Ala Ser Gly Ala 
    690                 695                 700                 

Met Lys Ala Ser Gln Trp Phe Lys Val Ser Asp Lys Trp Tyr Tyr Val 
705                 710                 715                 720 

Asn Gly Leu Gly Ala Leu Ala Val Asn Thr Thr Val Asp Gly Tyr Lys 
                725                 730                 735     

Val Asn Ala Asn Gly Glu Trp Val 
            740                 

<210>   33
<211>   1119
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   33
atgagtgata actctaaaac acgtgttgtc gtggggatga gtggtggtgt tgattcgtcg   60
gtgacggctc ttttgctcaa ggagcagggc tacgatgtga tcggtatctt catgaagaac   120
tgggatgaca cagatgaaaa cggcgtctgt acggcgaccg aagattacaa ggatgtggtt   180
gcggtggcag accagattgg cattccctac tactctgtca attttgaaaa agagtactgg   240
gaccgcgttt ttgagtattt cctagcggaa taccgtgcag ggcgcacgcc aaatccggac   300
gttatgtgca acaaggaaat caagttcaag gcctttttgg actatgccat aaccttgggg   360
gcagactatg tagcgactgg gcattatgct cgagtggcgc gtgatgagga tggtaccgtt   420
cacatgcttc gtggcgtgga caatggcaag gatcagacct atttcctcag ccaactttcg   480
caagaacaac ttcaaaaaac catgttccca ctaggacatt tggaaaagcc tgaagtacgc   540
agactagcag aagaagcagg cctttcgact gctaagaaga aagactcgac agggatttgc   600
tttatcggag aaaagaactt taaaaacttt ctcagcaact acctgccagc tcagcctggt   660
cgcatgatga ctgtggatgg tcgcgatatg ggcgagcatg caggtcttat gtactataca   720
atcggtcagc gtggcggact cggtatcggt gggcaacacg gcggtgacaa tgccccttgg   780
ttcgttgtcg gaaaagatct aagcaagaat attctctatg taggacaagg attctaccat   840
gattcgctca tgtcaactag cctagaagcc agtcaagtcc actttactcg tgaaatgcca   900
gaagagttta cgctagaatg tacggctaaa ttccgttacc gtcagcctga ctctaaggtg   960
accgttcatg tcaaaggaga aaagacagag gtcatctttg cggaaccaca acgcgcgatt   1020
acaccaggac aggcagttgt cttttacgat ggcgaagagt gtctaggtgg cggtttgatt   1080
gacaatgctt accgcgatgg acaagtttgt cagtacatt                          1119

<210>   34
<211>   373
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (trmU)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902166 (0.E+01)

<400>   34
Met Ser Asp Asn Ser Lys Thr Arg Val Val Val Gly Met Ser Gly Gly 
1               5                   10                  15      

Val Asp Ser Ser Val Thr Ala Leu Leu Leu Lys Glu Gln Gly Tyr Asp 
            20                  25                  30          

Val Ile Gly Ile Phe Met Lys Asn Trp Asp Asp Thr Asp Glu Asn Gly 
        35                  40                  45              

Val Cys Thr Ala Thr Glu Asp Tyr Lys Asp Val Val Ala Val Ala Asp 
    50                  55                  60                  

Gln Ile Gly Ile Pro Tyr Tyr Ser Val Asn Phe Glu Lys Glu Tyr Trp 
65                  70                  75                  80  

Asp Arg Val Phe Glu Tyr Phe Leu Ala Glu Tyr Arg Ala Gly Arg Thr 
                85                  90                  95      

Pro Asn Pro Asp Val Met Cys Asn Lys Glu Ile Lys Phe Lys Ala Phe 
            100                 105                 110         

Leu Asp Tyr Ala Ile Thr Leu Gly Ala Asp Tyr Val Ala Thr Gly His 
        115                 120                 125             

Tyr Ala Arg Val Ala Arg Asp Glu Asp Gly Thr Val His Met Leu Arg 
    130                 135                 140                 

Gly Val Asp Asn Gly Lys Asp Gln Thr Tyr Phe Leu Ser Gln Leu Ser 
145                 150                 155                 160 

Gln Glu Gln Leu Gln Lys Thr Met Phe Pro Leu Gly His Leu Glu Lys 
                165                 170                 175     

Pro Glu Val Arg Arg Leu Ala Glu Glu Ala Gly Leu Ser Thr Ala Lys 
            180                 185                 190         

Lys Lys Asp Ser Thr Gly Ile Cys Phe Ile Gly Glu Lys Asn Phe Lys 
        195                 200                 205             

Asn Phe Leu Ser Asn Tyr Leu Pro Ala Gln Pro Gly Arg Met Met Thr 
    210                 215                 220                 

Val Asp Gly Arg Asp Met Gly Glu His Ala Gly Leu Met Tyr Tyr Thr 
225                 230                 235                 240 

Ile Gly Gln Arg Gly Gly Leu Gly Ile Gly Gly Gln His Gly Gly Asp 
                245                 250                 255     

Asn Ala Pro Trp Phe Val Val Gly Lys Asp Leu Ser Lys Asn Ile Leu 
            260                 265                 270         

Tyr Val Gly Gln Gly Phe Tyr His Asp Ser Leu Met Ser Thr Ser Leu 
        275                 280                 285             

Glu Ala Ser Gln Val His Phe Thr Arg Glu Met Pro Glu Glu Phe Thr 
    290                 295                 300                 

Leu Glu Cys Thr Ala Lys Phe Arg Tyr Arg Gln Pro Asp Ser Lys Val 
305                 310                 315                 320 

Thr Val His Val Lys Gly Glu Lys Thr Glu Val Ile Phe Ala Glu Pro 
                325                 330                 335     

Gln Arg Ala Ile Thr Pro Gly Gln Ala Val Val Phe Tyr Asp Gly Glu 
            340                 345                 350         

Glu Cys Leu Gly Gly Gly Leu Ile Asp Asn Ala Tyr Arg Asp Gly Gln 
        355                 360                 365             

Val Cys Gln Tyr Ile 
    370             

<210>   35
<211>   480
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   35
ttgtgtcgtt taagggaaag gacaagaatg actcaacaag actttcggac aaaagtagac   60
aatacggttt ttggtgttcg ggctacagcc ttgattgtcc aaaatcacaa gcttctagtt   120
accaaagaca agggcaagta ttacactatt ggaggtgcga ttcaagtcaa tgaaagcacg   180
gaagacgcgg tagtccgtga agtgaaggaa gaactgggtg tcaaagctca agctgggcag   240
ctagcttttg tggttgaaaa tcgttttgaa gtggacggcg tttcctatca caatatcgag   300
tttcattatc tggtggattt gcttgaagat gccccgttga ccatgcagga agatgagaaa   360
aggcagccct gtgagtggat tgacttggat aagctccaga atatccagct agttccagtc   420
tttttaaaaa cagccctacc agattgggaa ggccaactaa gacacattca tcttgaggaa   480

<210>   36
<211>   160
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MutT/nudix family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902167 (4.E-82)

<400>   36
Met Cys Arg Leu Arg Glu Arg Thr Arg Met Thr Gln Gln Asp Phe Arg 
1               5                   10                  15      

Thr Lys Val Asp Asn Thr Val Phe Gly Val Arg Ala Thr Ala Leu Ile 
            20                  25                  30          

Val Gln Asn His Lys Leu Leu Val Thr Lys Asp Lys Gly Lys Tyr Tyr 
        35                  40                  45              

Thr Ile Gly Gly Ala Ile Gln Val Asn Glu Ser Thr Glu Asp Ala Val 
    50                  55                  60                  

Val Arg Glu Val Lys Glu Glu Leu Gly Val Lys Ala Gln Ala Gly Gln 
65                  70                  75                  80  

Leu Ala Phe Val Val Glu Asn Arg Phe Glu Val Asp Gly Val Ser Tyr 
                85                  90                  95      

His Asn Ile Glu Phe His Tyr Leu Val Asp Leu Leu Glu Asp Ala Pro 
            100                 105                 110         

Leu Thr Met Gln Glu Asp Glu Lys Arg Gln Pro Cys Glu Trp Ile Asp 
        115                 120                 125             

Leu Asp Lys Leu Gln Asn Ile Gln Leu Val Pro Val Phe Leu Lys Thr 
    130                 135                 140                 

Ala Leu Pro Asp Trp Glu Gly Gln Leu Arg His Ile His Leu Glu Glu 
145                 150                 155                 160 


<210>   37
<211>   1911
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   37
atgacttatc attttactga agaatacgat attattgtaa ttggtgcggg acacgctggg   60
gttgaggctt ccttggccgc tagccgtatg ggctgtaagg tcctgcttgc gaccatcaat   120
attgaaatgc tggctttcat gccttgtaat ccctctatcg gtggttctgc caaggggatt   180
gtcgtgcgtg aagtcgatgc cctcggtggc gagatggcca aaaccattga caagacttac   240
atccagatga agatgctaaa cacagggaag gggccagctg tccgtgccct tcgtgcgcag   300
gctgacaagg aactttactc taaggagatg cgcaagacgg ttgaaaacca agaaaatctg   360
acccttcgtc aaaccatgat tgatgagatt ttggtggaag atggcaaggt tgtcggtgtg   420
cgtacagcca cccatcaaga atatgctgct aaggctgtta ttgtgacgac agggactgct   480
ctccgtgggg aaattatcat cggagacctc aagtactcat caggtcctaa ccacagcttg   540
gcttctatta acctagctga caatctcaag gaactgggtc tcgaaatcgg tcgtttcaag   600
acaggaaccc ctccacgtgt caaggcttct tctatcaatt acgatgtgac agaaattcag   660
ccaggagacg aagtgcctaa tcatttctca tacacttcac gtgatgagga ttatgtcaag   720
gaccaagtac catgctggtt gacctatacc aatggtacca gtcatgagat tatccaaaac   780
aacctccacc gtgcgcctat gtttacaggt gtggtcaagg gagtggggcc tcgttactgt   840
ccgtcgattg aagacaagat tgtgcgcttt gcggacaagg aacgtcacca actcttcctt   900
gagccagaag ggcgcaatac tgaggaagtc tatgtgcaag gactttcaac cagtctgcct   960
gaggatgtcc agcgtgactt ggtgcattcc atcaaaggtt tggaaaatgc agagatgatg   1020
cggacaggtt atgctattga gtatgatatg gtcttgcctc atcagttgcg tgcgactttg   1080
gaaaccaaga aaatctcagg tctcttcact gctggtcaga caaatggaac atcaggttac   1140
gaagaggcag caggccaagg gattatcgcg ggtatcaatg cggctctgaa aatccaaggc   1200
aagcctgaat tgattttgaa gcgcagtgat ggttatatcg gggtgatgat cgacgacttg   1260
gtgaccaagg gaaccattga accctaccgt ctcttgacca gtcgtgctga ataccgtctc   1320
attcttcgtc atgacaatgc tgatatgcgc ttgactgaga tgggacgcga gattggcctt   1380
gtggacgatg aacgctgggc tcgttttgaa atcaagaaaa atcaatttga taatgagatg   1440

aagcgcctag acagtatcaa actcaagcca gtcaaggaaa ccaatgccaa ggttgaggag   1500
atgggcttca aacccttgac cgatgcagtg acagccaagg aattccttcg ccgtccagaa   1560
gtttcttacc aagatgtggt ggccttcatc ggaccagctg cagaagactt ggatgacaag   1620
attatcgaat tgattgaaac agaaatcaag tatgaaggct atatttccaa agccatggac   1680
caggttgcca agatgaaacg catggaagaa aaacgcattc cggccaatat cgactgggat   1740
gacattgatt ctatcgcaac cgaagcccgt cagaagttca aactcatcaa tccagaaacc   1800
atcggccaag ccagccgtat ttcgggagta aacccagcag atatttctat tttgatggtg   1860
tatctggaag gtaaaaatcg tagtatttct aaaactcttc aaaaatcaaa a            1911

<210>   38
<211>   637
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucose-inhibited division protein A (gidA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902168 (0.E+01)

<400>   38
Met Thr Tyr His Phe Thr Glu Glu Tyr Asp Ile Ile Val Ile Gly Ala 
1               5                   10                  15      

Gly His Ala Gly Val Glu Ala Ser Leu Ala Ala Ser Arg Met Gly Cys 
            20                  25                  30          

Lys Val Leu Leu Ala Thr Ile Asn Ile Glu Met Leu Ala Phe Met Pro 
        35                  40                  45              

Cys Asn Pro Ser Ile Gly Gly Ser Ala Lys Gly Ile Val Val Arg Glu 
    50                  55                  60                  

Val Asp Ala Leu Gly Gly Glu Met Ala Lys Thr Ile Asp Lys Thr Tyr 
65                  70                  75                  80  

Ile Gln Met Lys Met Leu Asn Thr Gly Lys Gly Pro Ala Val Arg Ala 
                85                  90                  95      

Leu Arg Ala Gln Ala Asp Lys Glu Leu Tyr Ser Lys Glu Met Arg Lys 
            100                 105                 110         

Thr Val Glu Asn Gln Glu Asn Leu Thr Leu Arg Gln Thr Met Ile Asp 
        115                 120                 125             

Glu Ile Leu Val Glu Asp Gly Lys Val Val Gly Val Arg Thr Ala Thr 
    130                 135                 140                 

His Gln Glu Tyr Ala Ala Lys Ala Val Ile Val Thr Thr Gly Thr Ala 
145                 150                 155                 160 

Leu Arg Gly Glu Ile Ile Ile Gly Asp Leu Lys Tyr Ser Ser Gly Pro 
                165                 170                 175     

Asn His Ser Leu Ala Ser Ile Asn Leu Ala Asp Asn Leu Lys Glu Leu 
            180                 185                 190         

Gly Leu Glu Ile Gly Arg Phe Lys Thr Gly Thr Pro Pro Arg Val Lys 
        195                 200                 205             

Ala Ser Ser Ile Asn Tyr Asp Val Thr Glu Ile Gln Pro Gly Asp Glu 
    210                 215                 220                 

Val Pro Asn His Phe Ser Tyr Thr Ser Arg Asp Glu Asp Tyr Val Lys 
225                 230                 235                 240 

Asp Gln Val Pro Cys Trp Leu Thr Tyr Thr Asn Gly Thr Ser His Glu 
                245                 250                 255     

Ile Ile Gln Asn Asn Leu His Arg Ala Pro Met Phe Thr Gly Val Val 
            260                 265                 270         

Lys Gly Val Gly Pro Arg Tyr Cys Pro Ser Ile Glu Asp Lys Ile Val 
        275                 280                 285             

Arg Phe Ala Asp Lys Glu Arg His Gln Leu Phe Leu Glu Pro Glu Gly 
    290                 295                 300                 

Arg Asn Thr Glu Glu Val Tyr Val Gln Gly Leu Ser Thr Ser Leu Pro 
305                 310                 315                 320 

Glu Asp Val Gln Arg Asp Leu Val His Ser Ile Lys Gly Leu Glu Asn 
                325                 330                 335     

Ala Glu Met Met Arg Thr Gly Tyr Ala Ile Glu Tyr Asp Met Val Leu 
            340                 345                 350         

Pro His Gln Leu Arg Ala Thr Leu Glu Thr Lys Lys Ile Ser Gly Leu 
        355                 360                 365             

Phe Thr Ala Gly Gln Thr Asn Gly Thr Ser Gly Tyr Glu Glu Ala Ala 
    370                 375                 380                 

Gly Gln Gly Ile Ile Ala Gly Ile Asn Ala Ala Leu Lys Ile Gln Gly 
385                 390                 395                 400 

Lys Pro Glu Leu Ile Leu Lys Arg Ser Asp Gly Tyr Ile Gly Val Met 
                405                 410                 415     

Ile Asp Asp Leu Val Thr Lys Gly Thr Ile Glu Pro Tyr Arg Leu Leu 
            420                 425                 430         

Thr Ser Arg Ala Glu Tyr Arg Leu Ile Leu Arg His Asp Asn Ala Asp 
        435                 440                 445             

Met Arg Leu Thr Glu Met Gly Arg Glu Ile Gly Leu Val Asp Asp Glu 
    450                 455                 460                 

Arg Trp Ala Arg Phe Glu Ile Lys Lys Asn Gln Phe Asp Asn Glu Met 
465                 470                 475                 480 

Lys Arg Leu Asp Ser Ile Lys Leu Lys Pro Val Lys Glu Thr Asn Ala 
                485                 490                 495     

Lys Val Glu Glu Met Gly Phe Lys Pro Leu Thr Asp Ala Val Thr Ala 
            500                 505                 510         

Lys Glu Phe Leu Arg Arg Pro Glu Val Ser Tyr Gln Asp Val Val Ala 
        515                 520                 525             

Phe Ile Gly Pro Ala Ala Glu Asp Leu Asp Asp Lys Ile Ile Glu Leu 
    530                 535                 540                 

Ile Glu Thr Glu Ile Lys Tyr Glu Gly Tyr Ile Ser Lys Ala Met Asp 
545                 550                 555                 560 

Gln Val Ala Lys Met Lys Arg Met Glu Glu Lys Arg Ile Pro Ala Asn 
                565                 570                 575     

Ile Asp Trp Asp Asp Ile Asp Ser Ile Ala Thr Glu Ala Arg Gln Lys 

            580                 585                 590         

Phe Lys Leu Ile Asn Pro Glu Thr Ile Gly Gln Ala Ser Arg Ile Ser 
        595                 600                 605             

Gly Val Asn Pro Ala Asp Ile Ser Ile Leu Met Val Tyr Leu Glu Gly 
    610                 615                 620                 

Lys Asn Arg Ser Ile Ser Lys Thr Leu Gln Lys Ser Lys 
625                 630                 635         

<210>   39
<211>   147
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   39
atgaaaatca aagagcaaac taggaagcta gccgtaggtt gctcaaagca ctgctttgag   60
gttgtagata gaactgacga agtcagtagc catacctacg gcaaggcgac gttgacgcgg   120
tttgaagaga ttttcgaaga gtatcaa                                       147

<210>   40
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   40
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Val Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser His Thr 
            20                  25                  30          

Tyr Gly Lys Ala Thr Leu Thr Arg Phe Glu Glu Ile Phe Glu Glu Tyr 
        35                  40                  45              

Gln 
    

<210>   41
<211>   1677
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   41
atggcctaca ctcttaaacc tgaagaagtc ggcgtttttg ccatcggtgg tctaggagaa   60
atcgggaaaa acacttacgg aattgaatac caagacgaga ttatcatcgt cgatgctggg   120
attaaattcc cagaagatga cttgcttggt atcgactatg tcattcctga ctactcttac   180
atcgtggaca atatcgaccg cgtcaaggct gttttaatca cacacggaca cgaggaccac   240
attggtggga ttccgttcct actcaagcaa gcaaatgtcc ctatttatgc tggaccgctt   300
gccttggctt tgatccgtgg gaaactcgaa gaacacggcc tcttgcgcaa cgccaaactt   360
tacgaaatca accacaacac cgagttgacc tttaaaaatc tcaaggcaac tttctttaga   420
acgactcact ctattccaga gcctttgggg attgtcattc atactcctca agggaaaatc   480
gtctgtacgg gtgactttaa gttcgacttt actccagttg gagaacctgc ggacttgcat   540
cgtatggctg cgcttggtga agaaggcgtg ctctgtctcc tgtctgactc gacaaatgcg   600
gaagtaccaa cctttaccaa ctctgaaaaa gtcgttggtc agtccattat gaagattatc   660
caaggtattg aaggacgtat catctttgca tcctttgcct caaatatctt ccgtctccag   720
caggcaacag aagctgctgt taagactgga cgcaagattg cggtctttgg tcgttctatg   780
gaaaaggcca ttgtcaacgg aatcgatctt ggctacatca aagctcctaa gggaaccttt   840
atcgagccaa atgaaatcaa agattatcct gcaggagaag ttcttatcct ctgtacaggt   900
agtcagggtg agcctatggc agccctctct cgtatcgcca acggaaccca ccgtcaagta   960
caattacaac caggtgatac cgttatcttc tcttctagtc ccatccctgg aaacactact   1020
agtgtcaaca agctgattaa catcatttct gaagctggtg tcgaagttat ccacggtaaa   1080
gtgaacaata tccatacatc tggacacggt ggtcagcaag agcaaaaact catgctctgc   1140
ttgattaagc caaaatactt catgcctgtc cacggtgaat accgcatgca aaaagtccac   1200
gctggactag cagtggatac tggtgttgag aaggacaata tctttatcat gagcaatggc   1260
gatgtgcttg cccttactgc tgactcagct cgtatcgcag gtcatttcaa cgcccaagat   1320
atctatgtcg atggaaatcg tatcggtgaa attggcgcag ctgtcctcaa agatcgtcgc   1380
gatctatctg aagacggtgt cgttctggca gttgcaactg ttgacttcaa atcgcagatg   1440
attctatctg gtccagacat cctcagccga ggctttgtct acatgagaga gtctggcgac   1500
ttgattcgcc aaagccagcg tatcctcttc aatgccattc gtatcgcact gaaaaataag   1560
gatgctagcg tgcaatctgt caatggtgcc attgtcaacg ctattcgccc cttcctctat   1620
gaaaataccg aacgtgaacc gatcatcatc ccgatgatcc tcacaccaga tgaagaa      1677

<210>   42
<211>   559
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   metallo-beta-lactamase superfamily protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902169 (0.E+01)

<400>   42
Met Ala Tyr Thr Leu Lys Pro Glu Glu Val Gly Val Phe Ala Ile Gly 
1               5                   10                  15      

Gly Leu Gly Glu Ile Gly Lys Asn Thr Tyr Gly Ile Glu Tyr Gln Asp 
            20                  25                  30          


Glu Ile Ile Ile Val Asp Ala Gly Ile Lys Phe Pro Glu Asp Asp Leu 
        35                  40                  45              

Leu Gly Ile Asp Tyr Val Ile Pro Asp Tyr Ser Tyr Ile Val Asp Asn 
    50                  55                  60                  

Ile Asp Arg Val Lys Ala Val Leu Ile Thr His Gly His Glu Asp His 
65                  70                  75                  80  

Ile Gly Gly Ile Pro Phe Leu Leu Lys Gln Ala Asn Val Pro Ile Tyr 
                85                  90                  95      

Ala Gly Pro Leu Ala Leu Ala Leu Ile Arg Gly Lys Leu Glu Glu His 
            100                 105                 110         

Gly Leu Leu Arg Asn Ala Lys Leu Tyr Glu Ile Asn His Asn Thr Glu 
        115                 120                 125             

Leu Thr Phe Lys Asn Leu Lys Ala Thr Phe Phe Arg Thr Thr His Ser 
    130                 135                 140                 

Ile Pro Glu Pro Leu Gly Ile Val Ile His Thr Pro Gln Gly Lys Ile 
145                 150                 155                 160 

Val Cys Thr Gly Asp Phe Lys Phe Asp Phe Thr Pro Val Gly Glu Pro 
                165                 170                 175     

Ala Asp Leu His Arg Met Ala Ala Leu Gly Glu Glu Gly Val Leu Cys 
            180                 185                 190         

Leu Leu Ser Asp Ser Thr Asn Ala Glu Val Pro Thr Phe Thr Asn Ser 
        195                 200                 205             

Glu Lys Val Val Gly Gln Ser Ile Met Lys Ile Ile Gln Gly Ile Glu 
    210                 215                 220                 

Gly Arg Ile Ile Phe Ala Ser Phe Ala Ser Asn Ile Phe Arg Leu Gln 
225                 230                 235                 240 

Gln Ala Thr Glu Ala Ala Val Lys Thr Gly Arg Lys Ile Ala Val Phe 
                245                 250                 255     

Gly Arg Ser Met Glu Lys Ala Ile Val Asn Gly Ile Asp Leu Gly Tyr 
            260                 265                 270         

Ile Lys Ala Pro Lys Gly Thr Phe Ile Glu Pro Asn Glu Ile Lys Asp 
        275                 280                 285             

Tyr Pro Ala Gly Glu Val Leu Ile Leu Cys Thr Gly Ser Gln Gly Glu 
    290                 295                 300                 

Pro Met Ala Ala Leu Ser Arg Ile Ala Asn Gly Thr His Arg Gln Val 
305                 310                 315                 320 

Gln Leu Gln Pro Gly Asp Thr Val Ile Phe Ser Ser Ser Pro Ile Pro 
                325                 330                 335     

Gly Asn Thr Thr Ser Val Asn Lys Leu Ile Asn Ile Ile Ser Glu Ala 
            340                 345                 350         

Gly Val Glu Val Ile His Gly Lys Val Asn Asn Ile His Thr Ser Gly 
        355                 360                 365             


His Gly Gly Gln Gln Glu Gln Lys Leu Met Leu Cys Leu Ile Lys Pro 
    370                 375                 380                 

Lys Tyr Phe Met Pro Val His Gly Glu Tyr Arg Met Gln Lys Val His 
385                 390                 395                 400 

Ala Gly Leu Ala Val Asp Thr Gly Val Glu Lys Asp Asn Ile Phe Ile 
                405                 410                 415     

Met Ser Asn Gly Asp Val Leu Ala Leu Thr Ala Asp Ser Ala Arg Ile 
            420                 425                 430         

Ala Gly His Phe Asn Ala Gln Asp Ile Tyr Val Asp Gly Asn Arg Ile 
        435                 440                 445             

Gly Glu Ile Gly Ala Ala Val Leu Lys Asp Arg Arg Asp Leu Ser Glu 
    450                 455                 460                 

Asp Gly Val Val Leu Ala Val Ala Thr Val Asp Phe Lys Ser Gln Met 
465                 470                 475                 480 

Ile Leu Ser Gly Pro Asp Ile Leu Ser Arg Gly Phe Val Tyr Met Arg 
                485                 490                 495     

Glu Ser Gly Asp Leu Ile Arg Gln Ser Gln Arg Ile Leu Phe Asn Ala 
            500                 505                 510         

Ile Arg Ile Ala Leu Lys Asn Lys Asp Ala Ser Val Gln Ser Val Asn 
        515                 520                 525             

Gly Ala Ile Val Asn Ala Ile Arg Pro Phe Leu Tyr Glu Asn Thr Glu 
    530                 535                 540                 

Arg Glu Pro Ile Ile Ile Pro Met Ile Leu Thr Pro Asp Glu Glu 

545                 550                 555                 

<210>   43
<211>   231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   43
atgatttaca aagtttttta tcaagaaaca aaagaacgta gcccacgccg tgaaacaaca   60
cgcacgcttt acctagacat cgatgccagc tcagaacttg agggccgtat cactgctcgc   120
caacttgtcg aagaaaatcg cccagagtac aatatcgagt atatcgaact cttgtctgac   180
aaattgctcg attacgaaaa agaaactggc gccttcgaaa ttacggagtt c            231

<210>   44
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902170 (6.E-40)

<400>   44
Met Ile Tyr Lys Val Phe Tyr Gln Glu Thr Lys Glu Arg Ser Pro Arg 
1               5                   10                  15      

Arg Glu Thr Thr Arg Thr Leu Tyr Leu Asp Ile Asp Ala Ser Ser Glu 
            20                  25                  30          

Leu Glu Gly Arg Ile Thr Ala Arg Gln Leu Val Glu Glu Asn Arg Pro 
        35                  40                  45              

Glu Tyr Asn Ile Glu Tyr Ile Glu Leu Leu Ser Asp Lys Leu Leu Asp 
    50                  55                  60                  

Tyr Glu Lys Glu Thr Gly Ala Phe Glu Ile Thr Glu Phe 
65                  70                  75          

<210>   45
<211>   213
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   45
atgtataact tatttgcttt tgctatcgga gctcgcttgg tagcttttat tgtttttgtt   60
gcttgcgttt atgcggggaa tcttctattt gccaaactgg aacgacgaca aaccaagttc   120
ttgtggaaaa tgacctttgt gactctctac tcgctttttc tcctcctcgt gacctatgtc   180
gtttggtttg tattttactt tgaattaaat gct                                213

<210>   46
<211>   71
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   46
Met Tyr Asn Leu Phe Ala Phe Ala Ile Gly Ala Arg Leu Val Ala Phe 

1               5                   10                  15      

Ile Val Phe Val Ala Cys Val Tyr Ala Gly Asn Leu Leu Phe Ala Lys 
            20                  25                  30          

Leu Glu Arg Arg Gln Thr Lys Phe Leu Trp Lys Met Thr Phe Val Thr 
        35                  40                  45              

Leu Tyr Ser Leu Phe Leu Leu Leu Val Thr Tyr Val Val Trp Phe Val 
    50                  55                  60                  

Phe Tyr Phe Glu Leu Asn Ala 
65                  70      

<210>   47
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   47
atgatgaaag atttgaacaa ttatcgtgaa atttctaata aggaattgca agaaatcaag   60
ggtggctttg gtgtcggtgt tggtatcgct ttatttatgg caggttatac cattggaaaa   120
gaccttcgta aaaagtttgg taagtcatgc                                    150

<210>   48
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902171 (1.E-24)

<400>   48
Met Met Lys Asp Leu Asn Asn Tyr Arg Glu Ile Ser Asn Lys Glu Leu 
1               5                   10                  15      

Gln Glu Ile Lys Gly Gly Phe Gly Val Gly Val Gly Ile Ala Leu Phe 
            20                  25                  30          

Met Ala Gly Tyr Thr Ile Gly Lys Asp Leu Arg Lys Lys Phe Gly Lys 
        35                  40                  45              

Ser Cys 
    50  

<210>   49
<211>   183
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   49
atgacaaatt ttgacattct tgacaatcaa tttttatcct tatctgaaaa tgaattatca   60
gatattgatg gcggtctcgc tcccttggtt atctttggag tagcagtatc ttggaaggct   120
attgcaggtg gaacagcact tataggttct ggtttggcag ctggttattt tttaggagga   180
gat                                                                 183

<210>   50
<211>   61
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902172 (1.E-30)

<400>   50
Met Thr Asn Phe Asp Ile Leu Asp Asn Gln Phe Leu Ser Leu Ser Glu 
1               5                   10                  15      

Asn Glu Leu Ser Asp Ile Asp Gly Gly Leu Ala Pro Leu Val Ile Phe 
            20                  25                  30          

Gly Val Ala Val Ser Trp Lys Ala Ile Ala Gly Gly Thr Ala Leu Ile 
        35                  40                  45              

Gly Ser Gly Leu Ala Ala Gly Tyr Phe Leu Gly Gly Asp 
    50                  55                  60      

<210>   51
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   51
ttgtcaagaa tgtcaaaatt tgtcattgaa ctttcctcct tttttcttgt tcacttttat   60
attcggaaaa gaaaaggaaa agtgagcatt tttttaaatt atttt                   105

<210>   52
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   52
Met Ser Arg Met Ser Lys Phe Val Ile Glu Leu Ser Ser Phe Phe Leu 
1               5                   10                  15      

Val His Phe Tyr Ile Arg Lys Arg Lys Gly Lys Val Ser Ile Phe Leu 
            20                  25                  30          

Asn Tyr Phe 
        35  

<210>   53
<211>   681
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   53
atgaaagtat tagcttttga tacgtccagc aaggctcttt ctctggctat tttagaggat   60
aagcaggttc ttgccgagac gacgattaat attaagaaaa atcacagtat tactcttatg   120
cctgccatcg attttttgat ggcaagtttg gattggacac ccaaggattt ggaccgaatc   180
gtggtagctg aagggccggg tagctataca ggcttgcgaa ttgcggtagc aactgctaag   240
accttagctc acaccctgaa catcgagttg gttggtatgt cgagtctctt ggctctggtg   300
ccccatcaac aagaaggttt gtttgtcccc ttgatggatg cgcgtcgcaa taatgtttat   360
gcaggatttt atgaaaatgc caaacctgtc atggcagaag cgcacctatc ttttgaagag   420
gtgctagaaa aagtcaaggg tactagtcag gtaacctttg tcggagaagt tggccccttt   480
gttgagcaga ttcaaaaaca cttgccaagg actgattaca aagaaacatt gcccaatgca   540
gctaatctag ctcttttggc ctgggacaag gaagcagact ccttgcatga ttttgtgccg   600
aattacctca aacgagtcga ggctgaggaa aactggctca agaaccatac cgagtctggc   660
gagtcttaca ttaaacgcct a                                             681

<210>   54
<211>   227
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902173 (e-124)

<400>   54
Met Lys Val Leu Ala Phe Asp Thr Ser Ser Lys Ala Leu Ser Leu Ala 
1               5                   10                  15      

Ile Leu Glu Asp Lys Gln Val Leu Ala Glu Thr Thr Ile Asn Ile Lys 
            20                  25                  30          

Lys Asn His Ser Ile Thr Leu Met Pro Ala Ile Asp Phe Leu Met Ala 
        35                  40                  45              

Ser Leu Asp Trp Thr Pro Lys Asp Leu Asp Arg Ile Val Val Ala Glu 
    50                  55                  60                  

Gly Pro Gly Ser Tyr Thr Gly Leu Arg Ile Ala Val Ala Thr Ala Lys 
65                  70                  75                  80  

Thr Leu Ala His Thr Leu Asn Ile Glu Leu Val Gly Met Ser Ser Leu 
                85                  90                  95      

Leu Ala Leu Val Pro His Gln Gln Glu Gly Leu Phe Val Pro Leu Met 
            100                 105                 110         

Asp Ala Arg Arg Asn Asn Val Tyr Ala Gly Phe Tyr Glu Asn Ala Lys 
        115                 120                 125             

Pro Val Met Ala Glu Ala His Leu Ser Phe Glu Glu Val Leu Glu Lys 
    130                 135                 140                 

Val Lys Gly Thr Ser Gln Val Thr Phe Val Gly Glu Val Gly Pro Phe 
145                 150                 155                 160 

Val Glu Gln Ile Gln Lys His Leu Pro Arg Thr Asp Tyr Lys Glu Thr 
                165                 170                 175     

Leu Pro Asn Ala Ala Asn Leu Ala Leu Leu Ala Trp Asp Lys Glu Ala 
            180                 185                 190         

Asp Ser Leu His Asp Phe Val Pro Asn Tyr Leu Lys Arg Val Glu Ala 
        195                 200                 205             

Glu Glu Asn Trp Leu Lys Asn His Thr Glu Ser Gly Glu Ser Tyr Ile 
    210                 215                 220                 

Lys Arg Leu 
225         

<210>   55
<211>   435
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   55
atgatagaaa tcaagcgaat tcaacaacag cctgacctag ctcaagccat ctacgctgtt   60
atggcagctg tttacctagt cagtccttgg actctggagc aaatccaagc agatctgtcc   120
caagaccaga cttggtatgc attggcttat gatggggcag aagtgattgg atttctagct   180
gtgcaggaga atctttttga agcagaagtc ctgcaaatcg ctgtcaaagg agcttatcag   240
ggtcagggga ttgcgtcagc cttgtttgct caattgccga cagacaagga aattttcctc   300
gaagtcagac agtcaaatca acgagcgcaa gcattttaca agaaagaaaa gatgacagtt   360
atcgctgagc gaaaggccta ctaccatgac ccagtcgagg acgccattat catgaagaga   420

gaaatagatg aagga                                                    435

<210>   56
<211>   145
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal-protein-alanine acetyltransferase, putative
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902174 (3.E-75)

<400>   56
Met Ile Glu Ile Lys Arg Ile Gln Gln Gln Pro Asp Leu Ala Gln Ala 
1               5                   10                  15      

Ile Tyr Ala Val Met Ala Ala Val Tyr Leu Val Ser Pro Trp Thr Leu 
            20                  25                  30          

Glu Gln Ile Gln Ala Asp Leu Ser Gln Asp Gln Thr Trp Tyr Ala Leu 
        35                  40                  45              

Ala Tyr Asp Gly Ala Glu Val Ile Gly Phe Leu Ala Val Gln Glu Asn 
    50                  55                  60                  

Leu Phe Glu Ala Glu Val Leu Gln Ile Ala Val Lys Gly Ala Tyr Gln 
65                  70                  75                  80  

Gly Gln Gly Ile Ala Ser Ala Leu Phe Ala Gln Leu Pro Thr Asp Lys 
                85                  90                  95      

Glu Ile Phe Leu Glu Val Arg Gln Ser Asn Gln Arg Ala Gln Ala Phe 
            100                 105                 110         

Tyr Lys Lys Glu Lys Met Thr Val Ile Ala Glu Arg Lys Ala Tyr Tyr 
        115                 120                 125             

His Asp Pro Val Glu Asp Ala Ile Ile Met Lys Arg Glu Ile Asp Glu 
    130                 135                 140                 

Gly 
145 

<210>   57
<211>   1008
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   57
atgaaggata gatatatttt agcatttgag acatcctgtg atgagaccag tgtcgccgtc   60
ttgaaaaacg acgatgagct cttgtccaat gtcattgcta gtcaaattga gagtcacaaa   120
cgttttggtg gcgtagtgcc cgaagtagcc agtcgtcacc atgtcgaggt cattacagcc   180
tgtatcgagg aggcattggc agaagcaggg attaccgaag aggacgtgac agctgttgcg   240
gttacctacg gaccaggctt ggtcggagcc ttgctagttg gtttgtcagc tgccaaggcc   300
tttgcttggg ctcacggact tccactgatt cctgttaatc acatggctgg gcacctcatg   360
gcagctcaga gtgtggagcc tttggagttt cccttgctag ccctcttggt cagcggcgga   420
cacacagagt tggtttatgt ttcggaggca ggagattata agattgttgg ggaaacccgt   480
gatgatgcgg ttggtgaggc ttatgataag gtcggccgtg tcatgggctt gacctatcct   540
gcaggtcgtg agattgacga gctggctcat caggggcagg atatttatga tttcccccgt   600
gccatgatta aggaagataa tctggagttc tccttctcag gtttgaaatc tgcctttatc   660
aatcttcatc acaatgccga gcaaaaggga gaaagcctgt ctacagaaga tttgtgtgct   720
tccttccaag cagcagttat ggacattctc atggcaaaaa ccaagaaggc tttggagaaa   780
tatcctgtta aaatcctagt tgtggcaggt ggtgtggcag ccaataaagg tctcagagaa   840
cgcctagcag ccgaaatcac agatgtcaag gttatcatcc cccctctgcg actctgcgga   900
gacaatgcag gtatgattgc ctatgccagc gtcagcgagt ggaacaaaga aaacttcgca   960
ggctgggacc tcaatgccaa accaagtctt gcctttgata ccatggaa                1008

<210>   58
<211>   336
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycoprotease family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902175 (0.E+01)

<400>   58
Met Lys Asp Arg Tyr Ile Leu Ala Phe Glu Thr Ser Cys Asp Glu Thr 
1               5                   10                  15      

Ser Val Ala Val Leu Lys Asn Asp Asp Glu Leu Leu Ser Asn Val Ile 
            20                  25                  30          

Ala Ser Gln Ile Glu Ser His Lys Arg Phe Gly Gly Val Val Pro Glu 
        35                  40                  45              

Val Ala Ser Arg His His Val Glu Val Ile Thr Ala Cys Ile Glu Glu 
    50                  55                  60                  

Ala Leu Ala Glu Ala Gly Ile Thr Glu Glu Asp Val Thr Ala Val Ala 
65                  70                  75                  80  


Val Thr Tyr Gly Pro Gly Leu Val Gly Ala Leu Leu Val Gly Leu Ser 
                85                  90                  95      

Ala Ala Lys Ala Phe Ala Trp Ala His Gly Leu Pro Leu Ile Pro Val 
            100                 105                 110         

Asn His Met Ala Gly His Leu Met Ala Ala Gln Ser Val Glu Pro Leu 
        115                 120                 125             

Glu Phe Pro Leu Leu Ala Leu Leu Val Ser Gly Gly His Thr Glu Leu 
    130                 135                 140                 

Val Tyr Val Ser Glu Ala Gly Asp Tyr Lys Ile Val Gly Glu Thr Arg 
145                 150                 155                 160 

Asp Asp Ala Val Gly Glu Ala Tyr Asp Lys Val Gly Arg Val Met Gly 
                165                 170                 175     

Leu Thr Tyr Pro Ala Gly Arg Glu Ile Asp Glu Leu Ala His Gln Gly 
            180                 185                 190         

Gln Asp Ile Tyr Asp Phe Pro Arg Ala Met Ile Lys Glu Asp Asn Leu 
        195                 200                 205             

Glu Phe Ser Phe Ser Gly Leu Lys Ser Ala Phe Ile Asn Leu His His 
    210                 215                 220                 

Asn Ala Glu Gln Lys Gly Glu Ser Leu Ser Thr Glu Asp Leu Cys Ala 
225                 230                 235                 240 

Ser Phe Gln Ala Ala Val Met Asp Ile Leu Met Ala Lys Thr Lys Lys 
                245                 250                 255     

Ala Leu Glu Lys Tyr Pro Val Lys Ile Leu Val Val Ala Gly Gly Val 
            260                 265                 270         

Ala Ala Asn Lys Gly Leu Arg Glu Arg Leu Ala Ala Glu Ile Thr Asp 
        275                 280                 285             

Val Lys Val Ile Ile Pro Pro Leu Arg Leu Cys Gly Asp Asn Ala Gly 
    290                 295                 300                 

Met Ile Ala Tyr Ala Ser Val Ser Glu Trp Asn Lys Glu Asn Phe Ala 
305                 310                 315                 320 

Gly Trp Asp Leu Asn Ala Lys Pro Ser Leu Ala Phe Asp Thr Met Glu 
                325                 330                 335     


<210>   59
<211>   1511
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   59
atggaacaac ttaagaatac cacagatttg ctcggattgg aagacaaaaa tatcaaaatc   60
ttgtctgttc tgaaatacca aacccatcta gtcgttcagg caaagttgga ttcccccgct   120
cctccttgtc ctcattgtca agggaagatg atcaaatacg acttccagaa agcctctaaa   180
attccgcttc tcgactgtca gggtttaccc acggtactgc atctcaaaaa gcgccgcttt   240
cagtgcaaga attgccttaa ggtggtcgtt tctcaaacat ccattgtcaa gaaaaattgc   300
cagatttcca acatggtgag acaaaaaatc gctcagctcc tccttgaaaa gcagtctatg   360
actgagattg cccacagatt ggcggtctca acttccaccg tcatccgaaa actgagggaa   420
tttaagtttg aaaccgattg gaccaagttg ccaaaagtta tgagttggga tgagtatagc   480
ttcaaaaaga gcaaaatgag cttcattgcc caagattttg agtccaaatc catcctcgca   540
attttagacg ggcgaactca tgcggtgatt cgaaaccatt tccaacgcta tcagagagag   600
gttcgggagc tggtcgaggt catcaccatg gacatgtaca gcccttatta tcggctcgct   660
aagcaactct ttccaaaggc gaagattgtt cttgaccgct tccacattgt ccaacatctg   720
agccgagcta tgaaccgagt acgaatccaa atcatgaacc aatttgaccg aaaatccttg   780
gagtatcggg cgctcaagcg cttttggaac cctcgctttt tcgtttctag gctcgggcta   840
aatcagtcca ctggactgat ttactacacc agtatagctt caagctctgt cagaaacgat   900
tctatcagcc cacgtttcga atgcacttaa cccatcggga agtacgagat aagctgcttt   960
cttactctga gggattacag gttcactacg aactctatca actcctgctc tttcattttc   1020
aagagaagaa tgccgaccat ttctttggat tgattgagca agaactgcca acggttcatc   1080
cgctttttca aacggtcttt tggacttttt taagggatag agataagatt atcaacgcac   1140
ttaagctgcc ttattccaac gctaaacttg aagcgaccaa taatttgatt aagattatca   1200
agcgcaaagc ctttggtttc cggaacttta acaattttaa aaaacggatt ttgatgactt   1260
tgaacatcaa aaaagagagt acgaatttcg tactctccag attgcagctt ttcgcctacc   1320
cactacactt gacaaagagc cactctttat tccatggtat caaaggcaag acttggtttg   1380
gcattgaggt cccagcctgc gaagttttct ttgttccact cgctgacgct ggcataggca   1440
atcatacctg cattgtctcc gcagagtcgc agagggggga tgataacctt gacatctgtg   1500
atttcggctg c                                                        1511

<210>   60
<211>   354
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase, fusion FRAMESHIFT

<400>   60
Met Glu Cys Phe Gly Ser Ile Ile Ser Val Val Gly Asn Pro Thr Pro 
1               5                   10                  15      

Gly Ile Ile Gly Ser Phe Leu Val Glu Lys Lys Pro His Met Thr Tyr 
            20                  25                  30          

Asn Glu Lys Arg Leu Thr Asn Ser Leu Glu Arg Val His Met Glu Gln 
        35                  40                  45              

Leu Lys Asn Thr Thr Asp Leu Leu Gly Leu Glu Asp Lys Asn Ile Lys 
    50                  55                  60                  

Ile Leu Ser Val Leu Lys Tyr Gln Thr His Leu Val Val Gln Ala Lys 
65                  70                  75                  80  

Leu Asp Ser Pro Ala Pro Pro Cys Pro His Cys Gln Gly Lys Met Ile 
                85                  90                  95      

Lys Tyr Asp Phe Gln Lys Ala Ser Lys Ile Pro Leu Leu Asp Cys Gln 
            100                 105                 110         

Gly Leu Pro Thr Val Leu His Leu Lys Lys Arg Arg Phe Gln Cys Lys 
        115                 120                 125             

Asn Cys Leu Lys Val Val Val Ser Gln Thr Ser Ile Val Lys Lys Asn 
    130                 135                 140                 

Cys Gln Ile Ser Asn Met Val Arg Gln Lys Ile Ala Gln Leu Leu Leu 
145                 150                 155                 160 

Glu Lys Gln Ser Met Thr Glu Ile Ala His Arg Leu Ala Val Ser Thr 
                165                 170                 175     

Ser Thr Val Ile Arg Lys Leu Arg Glu Phe Lys Phe Glu Thr Asp Trp 
            180                 185                 190         

Thr Lys Leu Pro Lys Val Met Ser Trp Asp Glu Tyr Ser Phe Lys Lys 
        195                 200                 205             

Ser Lys Met Ser Phe Ile Ala Gln Asp Phe Glu Ser Lys Ser Ile Leu 
    210                 215                 220                 

Ala Ile Leu Asp Gly Arg Thr His Ala Val Ile Arg Asn His Phe Gln 
225                 230                 235                 240 

Arg Tyr Gln Arg Glu Val Arg Glu Leu Val Glu Val Ile Thr Met Asp 
                245                 250                 255     

Met Tyr Ser Pro Tyr Tyr Arg Leu Ala Lys Gln Leu Phe Pro Lys Ala 
            260                 265                 270         

Lys Ile Val Leu Asp Arg Phe His Ile Val Gln His Leu Ser Arg Ala 
        275                 280                 285             

Met Asn Arg Val Arg Ile Gln Ile Met Asn Gln Phe Asp Arg Lys Ser 
    290                 295                 300                 

Leu Glu Tyr Arg Ala Leu Lys Arg Phe Trp Asn Pro Arg Phe Phe Val 
305                 310                 315                 320 

Ser Arg Leu Gly Leu Asn Gln Ser Thr Gly Leu Ile Tyr Tyr Thr Ser 
                325                 330                 335     

Ile Ala Ser Ser Ser Val Arg Asn Asp Ser Ile Ser Pro Arg Phe Glu 
            340                 345                 350         

Cys Thr 
        

<210>   61
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   61
ttgactgaaa tagctgctga attcaactgt cctccaacaa ctattcatta cgctctaaag   60
gctatgggat atagtctaaa aaagagccgt acctactgcg aacaagaccc agaaaaagta   120
aatcggttcc ttaaagaatt gaatcactta agctacctga ctcctattta tatttatgag   180
acaggggttg agacctattt ttatctcgaa tatgatcgag ccttgagcag gcagttagtc   240
tctctggaag aagatataat tatt                                          264

<210>   62
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1, truncation FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902178 (1.E-21)

<400>   62
Met Thr Glu Ile Ala Ala Glu Phe Asn Cys Pro Pro Thr Thr Ile His 
1               5                   10                  15      

Tyr Ala Leu Lys Ala Met Gly Tyr Ser Leu Lys Lys Ser Arg Thr Tyr 
            20                  25                  30          

Cys Glu Gln Asp Pro Glu Lys Val Asn Arg Phe Leu Lys Glu Leu Asn 
        35                  40                  45              

His Leu Ser Tyr Leu Thr Pro Ile Tyr Ile Tyr Glu Thr Gly Val Glu 
    50                  55                  60                  

Thr Tyr Phe Tyr Leu Glu Tyr Asp Arg Ala Leu Ser Arg Gln Leu Val 
65                  70                  75                  80  

Ser Leu Glu Glu Asp Ile Ile Ile 
                85              

<210>   63
<211>   561
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   63
atggttacaa tgcaatatag ttgtggaaaa ataaatatta atatccctga tggatatgga   60
gacattaagg atatagtgtt ttcggctcat attatagtta ggtataataa tggacattgt   120
ggaggtatag atccgcatat aattggactt tgtaaaaagc agatcagaag gatgtctcta   180
tatcctattt tgataattgt atctagagat tcaaaggtta ttgatgatta taaaaattta   240
gatattgcct atgttgattg tactcaatgt tcaaataatt ttgaaactgc cttacacgtt   300
aaaaatattt taaaattatt aaaaatccaa cttatacact gtcatggcta ctcaactaat   360
tattttttat atatgttaaa aaaacttgac aagaatggat ttggaaaggt taagacagtg   420
ataacatgcc atggatgggt tgaatataac ttaaaaaaga aattcttgac ttattttgat   480
ttttggacat attctatggg agatgctttt atttgtgtat ctgaaactat gaaaaaaaag   540
attggagagt ataataaaaa a                                             561

<210>   64
<211>   187
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Glycosyltransferase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902179 (e-107)

<400>   64
Met Val Thr Met Gln Tyr Ser Cys Gly Lys Ile Asn Ile Asn Ile Pro 
1               5                   10                  15      

Asp Gly Tyr Gly Asp Ile Lys Asp Ile Val Phe Ser Ala His Ile Ile 
            20                  25                  30          

Val Arg Tyr Asn Asn Gly His Cys Gly Gly Ile Asp Pro His Ile Ile 
        35                  40                  45              

Gly Leu Cys Lys Lys Gln Ile Arg Arg Met Ser Leu Tyr Pro Ile Leu 
    50                  55                  60                  

Ile Ile Val Ser Arg Asp Ser Lys Val Ile Asp Asp Tyr Lys Asn Leu 
65                  70                  75                  80  

Asp Ile Ala Tyr Val Asp Cys Thr Gln Cys Ser Asn Asn Phe Glu Thr 
                85                  90                  95      

Ala Leu His Val Lys Asn Ile Leu Lys Leu Leu Lys Ile Gln Leu Ile 
            100                 105                 110         

His Cys His Gly Tyr Ser Thr Asn Tyr Phe Leu Tyr Met Leu Lys Lys 
        115                 120                 125             

Leu Asp Lys Asn Gly Phe Gly Lys Val Lys Thr Val Ile Thr Cys His 
    130                 135                 140                 


Gly Trp Val Glu Tyr Asn Leu Lys Lys Lys Phe Leu Thr Tyr Phe Asp 
145                 150                 155                 160 

Phe Trp Thr Tyr Ser Met Gly Asp Ala Phe Ile Cys Val Ser Glu Thr 
                165                 170                 175     

Met Lys Lys Lys Ile Gly Glu Tyr Asn Lys Lys 
            180                 185         

<210>   65
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   65
ttggagagta taataaaaaa taagaagata gttgcaataa ataacggaat taatgtatca   60
aatagcgatt tagatgtagt aggtgttcaa gactttaaaa aagaattttg tattccaaat   120
aacaaaaaat catttgttat gttggaaggt tggatccaga aaaaaggccg gatagattcc   180
ttgaatttgc agaaaaatta tttt                                          204

<210>   66
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Glycosyltransferase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902179 (6.E-20)

<400>   66
Met Glu Ser Ile Ile Lys Asn Lys Lys Ile Val Ala Ile Asn Asn Gly 
1               5                   10                  15      

Ile Asn Val Ser Asn Ser Asp Leu Asp Val Val Gly Val Gln Asp Phe 
            20                  25                  30          

Lys Lys Glu Phe Cys Ile Pro Asn Asn Lys Lys Ser Phe Val Met Leu 
        35                  40                  45              

Glu Gly Trp Ile Gln Lys Lys Gly Arg Ile Asp Ser Leu Asn Leu Gln 
    50                  55                  60                  

Lys Asn Tyr Phe 
65              

<210>   67
<211>   453
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   67
gtgattttta ttatggctgg aaatggtagt atgtgggctg ctttgaaaga aaaaatttgc   60
catttgaaat gtagagataa tttcaggtta cttggtgaaa tctatccagc tactatagtt   120
taccaaatat cggatttatt gtatattcct tctgatacag aaggaatacc tatgtgtgtt   180
ttagagtcaa tgtcacaagg aactccggtt ttagctagta atgttggcgg gttaagtgaa   240
attattgaac atagggttga tggattttta tttgagaagg aagatgttga gggagtgtgt   300
gcttgtgcta attttttact caatgattct gagtatttga aatatatagg tgagaatagt   360
aaatcaaaaa taagaaaaca tttttctgtg caaaaaatgt ttgtagaaac catgagagta   420
tatgatgaat tattagagaa gagtagtcat gga                                453

<210>   68
<211>   151
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902179 (2.E-82)

<400>   68
Met Ile Phe Ile Met Ala Gly Asn Gly Ser Met Trp Ala Ala Leu Lys 
1               5                   10                  15      

Glu Lys Ile Cys His Leu Lys Cys Arg Asp Asn Phe Arg Leu Leu Gly 
            20                  25                  30          

Glu Ile Tyr Pro Ala Thr Ile Val Tyr Gln Ile Ser Asp Leu Leu Tyr 
        35                  40                  45              

Ile Pro Ser Asp Thr Glu Gly Ile Pro Met Cys Val Leu Glu Ser Met 
    50                  55                  60                  

Ser Gln Gly Thr Pro Val Leu Ala Ser Asn Val Gly Gly Leu Ser Glu 
65                  70                  75                  80  

Ile Ile Glu His Arg Val Asp Gly Phe Leu Phe Glu Lys Glu Asp Val 
                85                  90                  95      

Glu Gly Val Cys Ala Cys Ala Asn Phe Leu Leu Asn Asp Ser Glu Tyr 
            100                 105                 110         

Leu Lys Tyr Ile Gly Glu Asn Ser Lys Ser Lys Ile Arg Lys His Phe 
        115                 120                 125             

Ser Val Gln Lys Met Phe Val Glu Thr Met Arg Val Tyr Asp Glu Leu 
    130                 135                 140                 

Leu Glu Lys Ser Ser His Gly 
145                 150     

<210>   69
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   69
atggatagga atatagatca agaattagta agtattataa taccaacaca taataggtat   60
gaatctctga ttagagctgt gaaaagttgt ttacatcaaa gttataaaaa tatcgaagtt   120
ataattattg atgataatta tagtaatgta aatttaagaa ataaaattat ccatcaattt   180
ggctatacca atcatagaat taagttaatt ttaagtaatg aagatttagg tgcaactaat   240
gccagaaaca taggtatcaa aaattctaga ggtaagtata tatcattttt agacgatgat   300
gatgaatata tgccagatcg aattttaaag ttgatggctt gttttaaaaa gagtagaatg   360
aagaatttag ctttagtttg tagttatgga ataataattt atccaaatgg tacacgagaa   420
gaggagaaga ccgattttgt tggaaatccc ttgtttgttc aaatggttca caatatagca   480
ggtacgtcat tttggttgtg taaaaaagag gtgctagaat taattaatgg ttttgagaaa   540
atagattcac atcaggacgg tgttgtttta ttaaaactac ttgttcaagg ataccaaatt   600
gatatagtgc gagaattctt ggtgaattac tacgctcaca gtaaagaaaa cggtatcact   660
ggagtgacac aaaaaacaat taatgcagat gaagaatatt ataattactg taggaaatat   720
tttaatttat tgagtttcaa cgagagaata ttggttacaa agaaatatta ttctttaaac   780
ataaagcggt tactattaat aggagacaaa tgcaaggctt taaaagtaat caagaaggca   840
agagaagaaa aaatttttaa cgaatttctt ttt                                873

<210>   70
<211>   291
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902180 (e-167)

<400>   70
Met Asp Arg Asn Ile Asp Gln Glu Leu Val Ser Ile Ile Ile Pro Thr 
1               5                   10                  15      

His Asn Arg Tyr Glu Ser Leu Ile Arg Ala Val Lys Ser Cys Leu His 
            20                  25                  30          

Gln Ser Tyr Lys Asn Ile Glu Val Ile Ile Ile Asp Asp Asn Tyr Ser 
        35                  40                  45              

Asn Val Asn Leu Arg Asn Lys Ile Ile His Gln Phe Gly Tyr Thr Asn 
    50                  55                  60                  

His Arg Ile Lys Leu Ile Leu Ser Asn Glu Asp Leu Gly Ala Thr Asn 
65                  70                  75                  80  

Ala Arg Asn Ile Gly Ile Lys Asn Ser Arg Gly Lys Tyr Ile Ser Phe 
                85                  90                  95      


Leu Asp Asp Asp Asp Glu Tyr Met Pro Asp Arg Ile Leu Lys Leu Met 
            100                 105                 110         

Ala Cys Phe Lys Lys Ser Arg Met Lys Asn Leu Ala Leu Val Cys Ser 
        115                 120                 125             

Tyr Gly Ile Ile Ile Tyr Pro Asn Gly Thr Arg Glu Glu Glu Lys Thr 
    130                 135                 140                 

Asp Phe Val Gly Asn Pro Leu Phe Val Gln Met Val His Asn Ile Ala 
145                 150                 155                 160 

Gly Thr Ser Phe Trp Leu Cys Lys Lys Glu Val Leu Glu Leu Ile Asn 
                165                 170                 175     

Gly Phe Glu Lys Ile Asp Ser His Gln Asp Gly Val Val Leu Leu Lys 
            180                 185                 190         

Leu Leu Val Gln Gly Tyr Gln Ile Asp Ile Val Arg Glu Phe Leu Val 
        195                 200                 205             

Asn Tyr Tyr Ala His Ser Lys Glu Asn Gly Ile Thr Gly Val Thr Gln 
    210                 215                 220                 

Lys Thr Ile Asn Ala Asp Glu Glu Tyr Tyr Asn Tyr Cys Arg Lys Tyr 
225                 230                 235                 240 

Phe Asn Leu Leu Ser Phe Asn Glu Arg Ile Leu Val Thr Lys Lys Tyr 
                245                 250                 255     

Tyr Ser Leu Asn Ile Lys Arg Leu Leu Leu Ile Gly Asp Lys Cys Lys 
            260                 265                 270         

Ala Leu Lys Val Ile Lys Lys Ala Arg Glu Glu Lys Ile Phe Asn Glu 
        275                 280                 285             

Phe Leu Phe 
    290     

<210>   71
<211>   1614
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   71
gtgtatacta ttataaaatc aaatataaaa aaatttagtt tattaacgat atttattgtt   60
gctggtcaat tattgctaat ttatgcagca actattaatg ctctggtgtt gaatgaatta   120
attgcgatga atttagagcg gtttttgaaa ttgtcaatct accaaatgat tgtctggtgt   180
gggataatat tccttgactg ggtagtgaaa aattatcagg ttgaagtgat ccaagagttt   240
aatctagaga ttcgaaatag agttgccaca gacatctcta actctaccta tcaagaattt   300
catagtaaat catcaggaac atatctttcg tggctaaata atgatgttca gactttaaat   360
gatcaggcgt ttaaacaact ttttttagta ataaaaggaa tttctggtac tatatttgca   420
gttgtgactc ttaatcacta tcattggtca ttgactgtag ccaccttgtt ttcattaatg   480
attatgctac ttgtaccaaa aatctttgca tcgaaaatgc gagaagttag tctaaattta   540
actaaccaaa atgaagcttt tttaaaatct agtgagacta tattgaatgg atttgatgtg   600
ttagcgtcct tgaatctttt atatgtattg cctaagaaaa ttaaagaagc aggaatttta   660
ttaaagatgg ttatacaaag aaagacaact gtagaaacgt tagcaggcgc tattagcttc   720
tttctcaata ttttttttca gatatctctc gtttttttaa caggctatct tgcaataaaa   780
ggaatagtga aaattggtac tattgaagca ataggagcac taacaggtgt tatttttaca   840
gcgctaggtg aattaggagg tcaattatcc tctattattg gtacgaagcc tattttttta   900
aaattgtatt caattaatcc aattgagtca aataaaatga atgatatcga accaaatgag   960
gtgaatagag attttccgtt atatgaagca aaaaatattt gctataagta tggagataaa   1020
gaaatattaa aaaacttaaa tttttgtttt caacgtaatg aaaagtattt aattttaggt   1080
gaaagtggaa gcgggaaatc tacattatta aaattattga atggcttttt gagagattat   1140
agtggagaat tgcgattctg cggggatgat ataaaaaaaa cctcctattt aaatatggtt   1200
tcgaatgttc tatatgtaga tcaaaaagct tatttgtttg aaggtacgat tagagataat   1260
attttattgg aagaaaatta tactgatgaa gaaatactac agtctttaga gcaagttggt   1320
ttgagtgtaa aagattttcc taataacatt ttagattatt atgttggtga tgatgggaga   1380
ttactgtcag gagggcagaa acaaaaaatt actttagcta gagggctaat tagaaataag   1440
aaaatagtat taattgacga gggaacttct gctatcgata ggagaacttc gttagcgatt   1500
gaacgtaaga tattagatag agaggatttg actgtcatta ttgttaccca tgctccgcat   1560
ccggaactta aacaatattt tactaagata tatcaatttc caaaggattt tatt         1614

<210>   72
<211>   538
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902181 (0.E+01)

<400>   72
Met Tyr Thr Ile Ile Lys Ser Asn Ile Lys Lys Phe Ser Leu Leu Thr 
1               5                   10                  15      

Ile Phe Ile Val Ala Gly Gln Leu Leu Leu Ile Tyr Ala Ala Thr Ile 
            20                  25                  30          

Asn Ala Leu Val Leu Asn Glu Leu Ile Ala Met Asn Leu Glu Arg Phe 
        35                  40                  45              

Leu Lys Leu Ser Ile Tyr Gln Met Ile Val Trp Cys Gly Ile Ile Phe 
    50                  55                  60                  

Leu Asp Trp Val Val Lys Asn Tyr Gln Val Glu Val Ile Gln Glu Phe 
65                  70                  75                  80  

Asn Leu Glu Ile Arg Asn Arg Val Ala Thr Asp Ile Ser Asn Ser Thr 
                85                  90                  95      

Tyr Gln Glu Phe His Ser Lys Ser Ser Gly Thr Tyr Leu Ser Trp Leu 
            100                 105                 110         

Asn Asn Asp Val Gln Thr Leu Asn Asp Gln Ala Phe Lys Gln Leu Phe 
        115                 120                 125             

Leu Val Ile Lys Gly Ile Ser Gly Thr Ile Phe Ala Val Val Thr Leu 
    130                 135                 140                 

Asn His Tyr His Trp Ser Leu Thr Val Ala Thr Leu Phe Ser Leu Met 
145                 150                 155                 160 

Ile Met Leu Leu Val Pro Lys Ile Phe Ala Ser Lys Met Arg Glu Val 
                165                 170                 175     

Ser Leu Asn Leu Thr Asn Gln Asn Glu Ala Phe Leu Lys Ser Ser Glu 
            180                 185                 190         

Thr Ile Leu Asn Gly Phe Asp Val Leu Ala Ser Leu Asn Leu Leu Tyr 
        195                 200                 205             

Val Leu Pro Lys Lys Ile Lys Glu Ala Gly Ile Leu Leu Lys Met Val 
    210                 215                 220                 

Ile Gln Arg Lys Thr Thr Val Glu Thr Leu Ala Gly Ala Ile Ser Phe 
225                 230                 235                 240 

Phe Leu Asn Ile Phe Phe Gln Ile Ser Leu Val Phe Leu Thr Gly Tyr 
                245                 250                 255     

Leu Ala Ile Lys Gly Ile Val Lys Ile Gly Thr Ile Glu Ala Ile Gly 
            260                 265                 270         

Ala Leu Thr Gly Val Ile Phe Thr Ala Leu Gly Glu Leu Gly Gly Gln 
        275                 280                 285             

Leu Ser Ser Ile Ile Gly Thr Lys Pro Ile Phe Leu Lys Leu Tyr Ser 
    290                 295                 300                 

Ile Asn Pro Ile Glu Ser Asn Lys Met Asn Asp Ile Glu Pro Asn Glu 
305                 310                 315                 320 

Val Asn Arg Asp Phe Pro Leu Tyr Glu Ala Lys Asn Ile Cys Tyr Lys 
                325                 330                 335     

Tyr Gly Asp Lys Glu Ile Leu Lys Asn Leu Asn Phe Cys Phe Gln Arg 
            340                 345                 350         

Asn Glu Lys Tyr Leu Ile Leu Gly Glu Ser Gly Ser Gly Lys Ser Thr 
        355                 360                 365             

Leu Leu Lys Leu Leu Asn Gly Phe Leu Arg Asp Tyr Ser Gly Glu Leu 
    370                 375                 380                 

Arg Phe Cys Gly Asp Asp Ile Lys Lys Thr Ser Tyr Leu Asn Met Val 
385                 390                 395                 400 

Ser Asn Val Leu Tyr Val Asp Gln Lys Ala Tyr Leu Phe Glu Gly Thr 
                405                 410                 415     

Ile Arg Asp Asn Ile Leu Leu Glu Glu Asn Tyr Thr Asp Glu Glu Ile 
            420                 425                 430         

Leu Gln Ser Leu Glu Gln Val Gly Leu Ser Val Lys Asp Phe Pro Asn 
        435                 440                 445             

Asn Ile Leu Asp Tyr Tyr Val Gly Asp Asp Gly Arg Leu Leu Ser Gly 
    450                 455                 460                 

Gly Gln Lys Gln Lys Ile Thr Leu Ala Arg Gly Leu Ile Arg Asn Lys 
465                 470                 475                 480 

Lys Ile Val Leu Ile Asp Glu Gly Thr Ser Ala Ile Asp Arg Arg Thr 
                485                 490                 495     

Ser Leu Ala Ile Glu Arg Lys Ile Leu Asp Arg Glu Asp Leu Thr Val 
            500                 505                 510         

Ile Ile Val Thr His Ala Pro His Pro Glu Leu Lys Gln Tyr Phe Thr 
        515                 520                 525             

Lys Ile Tyr Gln Phe Pro Lys Asp Phe Ile 
    530                 535             

<210>   73
<211>   477
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   73
gtgcagttca ttttgcatag ttttggcatt catcctagat atccatataa aatgtctgag   60
attgttgaaa tgtctaaaaa aatatcagat ctaaacgata aaaaagaatt tcacaaaaag   120
aactgtgagt tgaggtttca agatagtgtt cttgataaca taaatagtgt cccgggtaca   180
actcatttat ttagttgttt aaatattcaa acattagtaa aaattatttt atatattttt   240
cgatacaaca gttgtatgaa aatatttaat tttagagata aagagcttat cttttttaat   300
aagattgtaa atgggctgat acaaaatatt gaggagaatt tagaggatga tattgaaagg   360
atattgaaat atttatatat atgtttattt aacgaaatat tcattattaa gaataaggtg   420
aatttttttg atgatgtgga atttaatcag acacttagtg agtttttaga taaattg      477

<210>   74
<211>   159
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   74
Met Gln Phe Ile Leu His Ser Phe Gly Ile His Pro Arg Tyr Pro Tyr 
1               5                   10                  15      

Lys Met Ser Glu Ile Val Glu Met Ser Lys Lys Ile Ser Asp Leu Asn 
            20                  25                  30          

Asp Lys Lys Glu Phe His Lys Lys Asn Cys Glu Leu Arg Phe Gln Asp 
        35                  40                  45              

Ser Val Leu Asp Asn Ile Asn Ser Val Pro Gly Thr Thr His Leu Phe 
    50                  55                  60                  

Ser Cys Leu Asn Ile Gln Thr Leu Val Lys Ile Ile Leu Tyr Ile Phe 
65                  70                  75                  80  

Arg Tyr Asn Ser Cys Met Lys Ile Phe Asn Phe Arg Asp Lys Glu Leu 
                85                  90                  95      

Ile Phe Phe Asn Lys Ile Val Asn Gly Leu Ile Gln Asn Ile Glu Glu 
            100                 105                 110         

Asn Leu Glu Asp Asp Ile Glu Arg Ile Leu Lys Tyr Leu Tyr Ile Cys 
        115                 120                 125             

Leu Phe Asn Glu Ile Phe Ile Ile Lys Asn Lys Val Asn Phe Phe Asp 
    130                 135                 140                 

Asp Val Glu Phe Asn Gln Thr Leu Ser Glu Phe Leu Asp Lys Leu 
145                 150                 155                 

<210>   75
<211>   753
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   75
atggttatga gtaacaatac taagtatatc tttttatctc cacatttaga tgacgcaatt   60
ttttcctgtg gtgattatat ttcaaaatta acttcagaag gagaaattgt acttgttatt   120
actatatttt ctggttaccc tttgagccaa cagctacagc cctctgctaa gcaatttcat   180
aagttgtgta accttgggaa atatccgatt gaagaaagga agaaagaaga caggttagct   240
tgtgaacgtc tacaatgtga ttttagacac ttatcgtact atgaatgtct ctataggaaa   300
gatagaaatg gcaattttct ataccgtcat atctatagtg aattaaaaaa tgaggacaca   360
ttaaagaatg atatcataaa agagctgtta atgcatttag acgacaaatg tgtcgtatat   420
tgtccgcttt cacttggtga ccatgttgct catgtttttg tgaatagtat tggaagggcg   480
cttgaattta tgcgttataa agtaatatat tatgaggact tcccatatgt aagtgatagt   540
agtatggtta gttatatggg aaaaactaaa gaattaaaaa tgtatcaaga ggaacttgat   600
gaaaaaaatt atattgatag aatatcatca atattgtgct ataaatctca gattttgata   660
atctggaaat cagttgaaaa acttttaaac aatattaaag agttgtattt aaggaatggg   720
gcagcttatt ctattagatt ttggattaag aaa                                753

<210>   76
<211>   251
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902182 (e-146)

<400>   76
Met Val Met Ser Asn Asn Thr Lys Tyr Ile Phe Leu Ser Pro His Leu 
1               5                   10                  15      

Asp Asp Ala Ile Phe Ser Cys Gly Asp Tyr Ile Ser Lys Leu Thr Ser 
            20                  25                  30          

Glu Gly Glu Ile Val Leu Val Ile Thr Ile Phe Ser Gly Tyr Pro Leu 
        35                  40                  45              

Ser Gln Gln Leu Gln Pro Ser Ala Lys Gln Phe His Lys Leu Cys Asn 
    50                  55                  60                  

Leu Gly Lys Tyr Pro Ile Glu Glu Arg Lys Lys Glu Asp Arg Leu Ala 
65                  70                  75                  80  

Cys Glu Arg Leu Gln Cys Asp Phe Arg His Leu Ser Tyr Tyr Glu Cys 
                85                  90                  95      

Leu Tyr Arg Lys Asp Arg Asn Gly Asn Phe Leu Tyr Arg His Ile Tyr 
            100                 105                 110         

Ser Glu Leu Lys Asn Glu Asp Thr Leu Lys Asn Asp Ile Ile Lys Glu 
        115                 120                 125             

Leu Leu Met His Leu Asp Asp Lys Cys Val Val Tyr Cys Pro Leu Ser 
    130                 135                 140                 

Leu Gly Asp His Val Ala His Val Phe Val Asn Ser Ile Gly Arg Ala 
145                 150                 155                 160 

Leu Glu Phe Met Arg Tyr Lys Val Ile Tyr Tyr Glu Asp Phe Pro Tyr 
                165                 170                 175     

Val Ser Asp Ser Ser Met Val Ser Tyr Met Gly Lys Thr Lys Glu Leu 
            180                 185                 190         

Lys Met Tyr Gln Glu Glu Leu Asp Glu Lys Asn Tyr Ile Asp Arg Ile 
        195                 200                 205             

Ser Ser Ile Leu Cys Tyr Lys Ser Gln Ile Leu Ile Ile Trp Lys Ser 
    210                 215                 220                 

Val Glu Lys Leu Leu Asn Asn Ile Lys Glu Leu Tyr Leu Arg Asn Gly 
225                 230                 235                 240 

Ala Ala Tyr Ser Ile Arg Phe Trp Ile Lys Lys 
                245                 250     

<210>   77
<211>   648
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   77
atgaatatag cagtaattgg tttggggcat gttgggctgg cctacgcgtt actatttgca   60
tctaaatata aagttgttgc atatgatata gattctgtaa aaataaataa tttaaaaaag   120
ggcattcttc catctaaaaa tgaagagctt atgaagtttt tttgcgagaa taacttaaat   180
attacttttt ttgatacatt ttctgaaatt aaaaataata ttgattatta tattattgcg   240
cttccgacag attatgatga gaaaattggt agttttaata catatgaaat cgaacaaacg   300
gtatcgaaga ttctgagggt aaaacctaat ggaaagatta ttttaaagtc aacagttccg   360
atcggctttt caaacaaatt aaaaaggctg tttgatacaa aaaatatcat ttttgtccct   420
gaatttttga gagaaggttg ttctatatat gataatttat atccaagtcg catagttgtt   480
ggagatgaga cagttgaagg aagaaaaatt gcagagttgt tcctttcgat tagtactcat   540
agtactgcca atattaaaaa tgttatgtta gtttctccta ctgaagcaga agcaattaag   600
cttttttcta acacattctt agctctccgt gttgcttttt taatgaac                648

<210>   78
<211>   216
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-glucose 6-dehydrogenase, FRAMESHIFT (ugd)

<400>   78
Met Asn Ile Ala Val Ile Gly Leu Gly His Val Gly Leu Ala Tyr Ala 
1               5                   10                  15      

Leu Leu Phe Ala Ser Lys Tyr Lys Val Val Ala Tyr Asp Ile Asp Ser 
            20                  25                  30          

Val Lys Ile Asn Asn Leu Lys Lys Gly Ile Leu Pro Ser Lys Asn Glu 
        35                  40                  45              

Glu Leu Met Lys Phe Phe Cys Glu Asn Asn Leu Asn Ile Thr Phe Phe 
    50                  55                  60                  

Asp Thr Phe Ser Glu Ile Lys Asn Asn Ile Asp Tyr Tyr Ile Ile Ala 
65                  70                  75                  80  

Leu Pro Thr Asp Tyr Asp Glu Lys Ile Gly Ser Phe Asn Thr Tyr Glu 
                85                  90                  95      

Ile Glu Gln Thr Val Ser Lys Ile Leu Arg Val Lys Pro Asn Gly Lys 
            100                 105                 110         

Ile Ile Leu Lys Ser Thr Val Pro Ile Gly Phe Ser Asn Lys Leu Lys 
        115                 120                 125             

Arg Leu Phe Asp Thr Lys Asn Ile Ile Phe Val Pro Glu Phe Leu Arg 
    130                 135                 140                 

Glu Gly Cys Ser Ile Tyr Asp Asn Leu Tyr Pro Ser Arg Ile Val Val 
145                 150                 155                 160 

Gly Asp Glu Thr Val Glu Gly Arg Lys Ile Ala Glu Leu Phe Leu Ser 
                165                 170                 175     

Ile Ser Thr His Ser Thr Ala Asn Ile Lys Asn Val Met Leu Val Ser 
            180                 185                 190         

Pro Thr Glu Ala Glu Ala Ile Lys Leu Phe Ser Asn Thr Phe Leu Ala 
        195                 200                 205             

Leu Arg Val Ala Phe Leu Met Asn 
    210                 215     

<210>   79
<211>   348
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   79
gtgatagaag cgattgatat ttcaaacaca aatagaaaac agttcatagt taaacaaata   60
ttggaacgaa agccaaagat agtaggaata tataaattgg ggatgaaata taattcagat   120
aattacaaag agtcagctat tttaagtata attaatgaac tattgattgt cggtataaaa   180
attttagtat atgaaccaaa tttaaacgtt agtatagata acgtaattat tgaaaagaat   240
tttgaactat ttacaaaaca aagtgatcta attgttgcaa atagatggga taggggcctt   300
gaagcttata aagataaagt ttacacaagg gggatctgga taagagat                348

<210>   80
<211>   116
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   putative UDP-glucose 6-dehydrogenase

<400>   80
Met Ile Glu Ala Ile Asp Ile Ser Asn Thr Asn Arg Lys Gln Phe Ile 
1               5                   10                  15      


Val Lys Gln Ile Leu Glu Arg Lys Pro Lys Ile Val Gly Ile Tyr Lys 
            20                  25                  30          

Leu Gly Met Lys Tyr Asn Ser Asp Asn Tyr Lys Glu Ser Ala Ile Leu 
        35                  40                  45              

Ser Ile Ile Asn Glu Leu Leu Ile Val Gly Ile Lys Ile Leu Val Tyr 
    50                  55                  60                  

Glu Pro Asn Leu Asn Val Ser Ile Asp Asn Val Ile Ile Glu Lys Asn 
65                  70                  75                  80  

Phe Glu Leu Phe Thr Lys Gln Ser Asp Leu Ile Val Ala Asn Arg Trp 
                85                  90                  95      

Asp Arg Gly Leu Glu Ala Tyr Lys Asp Lys Val Tyr Thr Arg Gly Ile 
            100                 105                 110         

Trp Ile Arg Asp 
        115     

<210>   81
<211>   861
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   81
atgattgaga gaatggaact gggggaattt tacaaggaat tacgtttggc gagaaagctc   60
aagcagtcag atgtggcttg tgagggtcta acagcttctc agttgtccaa gtttgaacta   120
gggcagtcta tgctgtctgc ggataagttg attctagcta tccaaggtat aaatgtgacc   180
tttgatgagt ttgggcacaa gctcaacaac tatcaagaat ctccacatat gcgaatcggt   240
cgaaaggttg tgaatcgctt tgcccatcag gatatagctg ctttagagca gctattggag   300
gaagtcgatc aagaacagat ggcgcagacc tatcgtcgtt tgaatgccat cgtgattaaa   360
gatgccatcc attcactaaa taaaagctac ccactagcag aggaggatag cgagtttttg   420
accacctatc tctatgctat cgagtcttgg acctggtttg aactctatct cttttgcaat   480
accatgccct tcttgagcaa tcaagatctg atttttttat caacctcctt actcgaaaaa   540
tccaaagaat ttaaagagtt agtacacaat cgattgtata tgaagcaagg actcttaaat   600
atcttatcag aactcatgga gcgaaaactt ttctcctaca tcccaatctt cgaagccgag   660
ttggagagga tgttacgacc gtatgatgtt tttgaaaaag tatcgtggca atttttaaag   720
aagatgagtg tctttcttca aacaaaggga agcaatcaaa aagagattga acgctttatc   780
caatctctgc aggtattaga aaatccacaa ttaatagccc tttttgaatt gcgttttcag   840
caatataaag aacttataga t                                             861

<210>   82
<211>   287
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902184 (e-161)

<400>   82
Met Ile Glu Arg Met Glu Leu Gly Glu Phe Tyr Lys Glu Leu Arg Leu 
1               5                   10                  15      

Ala Arg Lys Leu Lys Gln Ser Asp Val Ala Cys Glu Gly Leu Thr Ala 
            20                  25                  30          

Ser Gln Leu Ser Lys Phe Glu Leu Gly Gln Ser Met Leu Ser Ala Asp 
        35                  40                  45              

Lys Leu Ile Leu Ala Ile Gln Gly Ile Asn Val Thr Phe Asp Glu Phe 
    50                  55                  60                  

Gly His Lys Leu Asn Asn Tyr Gln Glu Ser Pro His Met Arg Ile Gly 
65                  70                  75                  80  

Arg Lys Val Val Asn Arg Phe Ala His Gln Asp Ile Ala Ala Leu Glu 
                85                  90                  95      

Gln Leu Leu Glu Glu Val Asp Gln Glu Gln Met Ala Gln Thr Tyr Arg 
            100                 105                 110         

Arg Leu Asn Ala Ile Val Ile Lys Asp Ala Ile His Ser Leu Asn Lys 
        115                 120                 125             

Ser Tyr Pro Leu Ala Glu Glu Asp Ser Glu Phe Leu Thr Thr Tyr Leu 
    130                 135                 140                 

Tyr Ala Ile Glu Ser Trp Thr Trp Phe Glu Leu Tyr Leu Phe Cys Asn 
145                 150                 155                 160 

Thr Met Pro Phe Leu Ser Asn Gln Asp Leu Ile Phe Leu Ser Thr Ser 
                165                 170                 175     

Leu Leu Glu Lys Ser Lys Glu Phe Lys Glu Leu Val His Asn Arg Leu 
            180                 185                 190         

Tyr Met Lys Gln Gly Leu Leu Asn Ile Leu Ser Glu Leu Met Glu Arg 
        195                 200                 205             

Lys Leu Phe Ser Tyr Ile Pro Ile Phe Glu Ala Glu Leu Glu Arg Met 
    210                 215                 220                 

Leu Arg Pro Tyr Asp Val Phe Glu Lys Val Ser Trp Gln Phe Leu Lys 

225                 230                 235                 240 

Lys Met Ser Val Phe Leu Gln Thr Lys Gly Ser Asn Gln Lys Glu Ile 
                245                 250                 255     

Glu Arg Phe Ile Gln Ser Leu Gln Val Leu Glu Asn Pro Gln Leu Ile 
            260                 265                 270         

Ala Leu Phe Glu Leu Arg Phe Gln Gln Tyr Lys Glu Leu Ile Asp 
        275                 280                 285         

<210>   83
<211>   231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   83
atgttaaatt tacaatttgc agaaacaatg gaattgacag aagctgagtt gcaagatgtt   60
agaggaggca acctcgtaaa ttctatggga ggtggtggaa gaagtggtat atctggttgg   120
ggcgtcccag gaatttaccc tggttggggc aatcaaggga tgagtcctaa tcgtggagct   180
tttgattgga ctatagattt agcagatgga ttgtttggcc gccgtagaag a            231

<210>   84
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902185 (3.E-43)

<400>   84
Met Leu Asn Leu Gln Phe Ala Glu Thr Met Glu Leu Thr Glu Ala Glu 
1               5                   10                  15      

Leu Gln Asp Val Arg Gly Gly Asn Leu Val Asn Ser Met Gly Gly Gly 
            20                  25                  30          

Gly Arg Ser Gly Ile Ser Gly Trp Gly Val Pro Gly Ile Tyr Pro Gly 
        35                  40                  45              

Trp Gly Asn Gln Gly Met Ser Pro Asn Arg Gly Ala Phe Asp Trp Thr 
    50                  55                  60                  

Ile Asp Leu Ala Asp Gly Leu Phe Gly Arg Arg Arg Arg 
65                  70                  75          

<210>   85
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   85
ttgttagatt tgcccacacg aacaataaga aaaaagaaag aaggaaaaca cccaggtaag   60
accaacgaaa ctggaaacga ccacactctt tccaatgttc acttt                   105

<210>   86
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   86
Met Leu Asp Leu Pro Thr Arg Thr Ile Arg Lys Lys Lys Glu Gly Lys 
1               5                   10                  15      

His Pro Gly Lys Thr Asn Glu Thr Gly Asn Asp His Thr Leu Ser Asn 
            20                  25                  30          

Val His Phe 
        35  

<210>   87
<211>   675
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   87
atgaagaaaa tgaaagaagt gaaatttcac ctagcaactg gcttgttgat tttgacttat   60
tacctcattt ttaatgtcac atcagactta gattttatgg ttgctttgtc tgataatatg   120
tactatgtgt tccaagtttt attggtactt attctgggaa ctatagctac aattgctttt   180
gtcaaaagtg aacattggaa agagtgtggt cgtttccagt ttcgttggtc ttacctgggt   240
gttttccttc tttctttttt cttattgttc gtgtgggcaa atctaacaac ctatatcttt   300
cctcgtaccc agaatggaag tacagtcgta gaagtagcca ccaatttaac aggaattagc   360
tattttgtta cgcgaatact ttatactagt attatcgcac ctgtatcaga agaggttgtt   420
tgtcgtggtc ttttgatgac aagtttatct aaagttaaga gatactatct tgatgttctt   480
gtttccgctg ccatatttgg cgctatgcat gttttgcagt atggttggat aacgacagat   540
ttcataaagt attttggaat gggcttgata ttttgtatga tgtttcgcta cacccgatcc   600
atctattggg ctatagctct gcatgcttca tggaatagtt tcttactcat tgttacttta   660
ttggtatttg gatat                                                    675

<210>   88
<211>   225
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902186 (e-128)

<400>   88
Met Lys Lys Met Lys Glu Val Lys Phe His Leu Ala Thr Gly Leu Leu 
1               5                   10                  15      

Ile Leu Thr Tyr Tyr Leu Ile Phe Asn Val Thr Ser Asp Leu Asp Phe 
            20                  25                  30          

Met Val Ala Leu Ser Asp Asn Met Tyr Tyr Val Phe Gln Val Leu Leu 
        35                  40                  45              

Val Leu Ile Leu Gly Thr Ile Ala Thr Ile Ala Phe Val Lys Ser Glu 
    50                  55                  60                  

His Trp Lys Glu Cys Gly Arg Phe Gln Phe Arg Trp Ser Tyr Leu Gly 
65                  70                  75                  80  

Val Phe Leu Leu Ser Phe Phe Leu Leu Phe Val Trp Ala Asn Leu Thr 
                85                  90                  95      

Thr Tyr Ile Phe Pro Arg Thr Gln Asn Gly Ser Thr Val Val Glu Val 
            100                 105                 110         

Ala Thr Asn Leu Thr Gly Ile Ser Tyr Phe Val Thr Arg Ile Leu Tyr 
        115                 120                 125             

Thr Ser Ile Ile Ala Pro Val Ser Glu Glu Val Val Cys Arg Gly Leu 
    130                 135                 140                 

Leu Met Thr Ser Leu Ser Lys Val Lys Arg Tyr Tyr Leu Asp Val Leu 
145                 150                 155                 160 

Val Ser Ala Ala Ile Phe Gly Ala Met His Val Leu Gln Tyr Gly Trp 
                165                 170                 175     

Ile Thr Thr Asp Phe Ile Lys Tyr Phe Gly Met Gly Leu Ile Phe Cys 
            180                 185                 190         

Met Met Phe Arg Tyr Thr Arg Ser Ile Tyr Trp Ala Ile Ala Leu His 
        195                 200                 205             

Ala Ser Trp Asn Ser Phe Leu Leu Ile Val Thr Leu Leu Val Phe Gly 
    210                 215                 220                 

Tyr 
225 

<210>   89
<211>   663
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   89
atgaaaaaga taatctcaca ccgctacttt attatagttt ttctactagt tattgctgac   60
cagaagttca gtgttctagt tttacgcagc gaccttgtta ctgggctatc tgactttgcc   120
tattatctgt cggatatgat gttgaatttt cttgtggttt tatttgctct tattgctatg   180
atttggtcgg ggaaatggca gaaaatcaat agtagaaagt ttaaaggatc ctatcttttc   240
tattccttcc tagctctgct tgcttttgtt gtttggaatt tcgttacctt ttttcttttc   300
ccacctactc gaaatgaaat ttcttatcaa catgctgctc cgacttttac aggggctaca   360
gcatttttga tgtatttttt ttatcctgtg attgcaggtc ccatttttga agacatgatt   420
tatcgtggat tagtgatgac tgctctggaa aaaggaaaga aatgggggct agatgtactt   480
ggttccgctg ttttatttgg ggtctcgcac attagtaatc acggttgggt cttgacagac   540
tttgtcttct atatgggtgg aggtcttata tttgcagtct tatttagaat gacaaagtca   600
atttattggc ctattggact gcatatagtc tacaatggca ttggtcagct tttgatgtta   660
ctg                                                                 663

<210>   90
<211>   221
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902187 (e-126)

<400>   90
Met Lys Lys Ile Ile Ser His Arg Tyr Phe Ile Ile Val Phe Leu Leu 
1               5                   10                  15      

Val Ile Ala Asp Gln Lys Phe Ser Val Leu Val Leu Arg Ser Asp Leu 
            20                  25                  30          

Val Thr Gly Leu Ser Asp Phe Ala Tyr Tyr Leu Ser Asp Met Met Leu 
        35                  40                  45              

Asn Phe Leu Val Val Leu Phe Ala Leu Ile Ala Met Ile Trp Ser Gly 
    50                  55                  60                  

Lys Trp Gln Lys Ile Asn Ser Arg Lys Phe Lys Gly Ser Tyr Leu Phe 
65                  70                  75                  80  

Tyr Ser Phe Leu Ala Leu Leu Ala Phe Val Val Trp Asn Phe Val Thr 
                85                  90                  95      

Phe Phe Leu Phe Pro Pro Thr Arg Asn Glu Ile Ser Tyr Gln His Ala 
            100                 105                 110         

Ala Pro Thr Phe Thr Gly Ala Thr Ala Phe Leu Met Tyr Phe Phe Tyr 
        115                 120                 125             

Pro Val Ile Ala Gly Pro Ile Phe Glu Asp Met Ile Tyr Arg Gly Leu 
    130                 135                 140                 

Val Met Thr Ala Leu Glu Lys Gly Lys Lys Trp Gly Leu Asp Val Leu 
145                 150                 155                 160 

Gly Ser Ala Val Leu Phe Gly Val Ser His Ile Ser Asn His Gly Trp 
                165                 170                 175     

Val Leu Thr Asp Phe Val Phe Tyr Met Gly Gly Gly Leu Ile Phe Ala 
            180                 185                 190         

Val Leu Phe Arg Met Thr Lys Ser Ile Tyr Trp Pro Ile Gly Leu His 
        195                 200                 205             

Ile Val Tyr Asn Gly Ile Gly Gln Leu Leu Met Leu Leu 
    210                 215                 220     

<210>   91
<211>   1224
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   91
atgaaagtat ttcttcaaaa tagagatttt aggcaattaa ctatcaacca gtggatttca   60
acgcttgggg atacgatttt ttatctggcc ttcctgaatt atgtggcaga tgcatctttt   120
gcccctttgg cgattttact catcacgatt tcagaaaccc tgccccaagt tctacaaatc   180
tttctgggag ttttggcgga ttttcaacat catcgtgtct tgaaatacac agtcattagt   240
tttgcaaaat ttttgcttta ctctatagtg tctttatcac tttcagggca gtctttctcc   300
ttgttgctag tagcatttat ttgtctgatt aacctcttgt ctgacacatt gagttatttt   360
tcaggcgcca tgctcactcc gattttcatt agaattattg ggcaagacca tctggcagaa   420
gctattggct ttaaacagtc aactgttagt ttagtgaaaa caatcagtaa tatcctagga   480
ggagtcttac taggcattct atccatccag tttatttcct tactgaacgc tcttaccttt   540
ttaatcgcat ttttaggtat cctcttcata aaaactgacc tcttgaaagt agaaaaaacg   600
attagctatc aagaaggact ctctgtaaaa tccttttgcc agcatttgct ccaatcatcg   660
aaattgatat ggaatatgaa taaggtgctc ttggttttgt ttattatctc tactagtcaa   720
gcagtgataa atgttacggt tcctatttcc actctatttt taaggaacca gccctttttg   780
aatttacaaa ctggtcaatc tcttgccttg ttagccacac tagaattatc agccctgatt   840
gtcggaagcc ttgtaagtgg ctatctgcaa cataccattt ccataaaaac agctctctat   900
gcctcacttg tcatccagtt gcttcttcta gtaggatttg ccacagttcg ttttgactgg   960
attctcatct ttagtacctt ggatgccttt ttcgcaggtg ttctctctcc tagattgcaa   1020
gaactcgttt ttaaacaaat acctgaggag tcaatgggag cagttcaatc ctctatcggt   1080
gccattacgg ttgttttacc tagcttattt acaatagctt tggtaaccat tgctactagc   1140
tttggaactc tggcagttag ctttgtttta ttgctatttc ttctagttgc ctttgttatg   1200
cttctgaata ttcgtgaaag tatt                                          1224

<210>   92
<211>   408
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902188 (0.E+01)

<400>   92
Met Lys Val Phe Leu Gln Asn Arg Asp Phe Arg Gln Leu Thr Ile Asn 
1               5                   10                  15      

Gln Trp Ile Ser Thr Leu Gly Asp Thr Ile Phe Tyr Leu Ala Phe Leu 
            20                  25                  30          

Asn Tyr Val Ala Asp Ala Ser Phe Ala Pro Leu Ala Ile Leu Leu Ile 
        35                  40                  45              

Thr Ile Ser Glu Thr Leu Pro Gln Val Leu Gln Ile Phe Leu Gly Val 
    50                  55                  60                  

Leu Ala Asp Phe Gln His His Arg Val Leu Lys Tyr Thr Val Ile Ser 
65                  70                  75                  80  

Phe Ala Lys Phe Leu Leu Tyr Ser Ile Val Ser Leu Ser Leu Ser Gly 
                85                  90                  95      

Gln Ser Phe Ser Leu Leu Leu Val Ala Phe Ile Cys Leu Ile Asn Leu 
            100                 105                 110         

Leu Ser Asp Thr Leu Ser Tyr Phe Ser Gly Ala Met Leu Thr Pro Ile 
        115                 120                 125             

Phe Ile Arg Ile Ile Gly Gln Asp His Leu Ala Glu Ala Ile Gly Phe 
    130                 135                 140                 

Lys Gln Ser Thr Val Ser Leu Val Lys Thr Ile Ser Asn Ile Leu Gly 
145                 150                 155                 160 

Gly Val Leu Leu Gly Ile Leu Ser Ile Gln Phe Ile Ser Leu Leu Asn 
                165                 170                 175     

Ala Leu Thr Phe Leu Ile Ala Phe Leu Gly Ile Leu Phe Ile Lys Thr 
            180                 185                 190         

Asp Leu Leu Lys Val Glu Lys Thr Ile Ser Tyr Gln Glu Gly Leu Ser 
        195                 200                 205             

Val Lys Ser Phe Cys Gln His Leu Leu Gln Ser Ser Lys Leu Ile Trp 
    210                 215                 220                 

Asn Met Asn Lys Val Leu Leu Val Leu Phe Ile Ile Ser Thr Ser Gln 
225                 230                 235                 240 

Ala Val Ile Asn Val Thr Val Pro Ile Ser Thr Leu Phe Leu Arg Asn 
                245                 250                 255     

Gln Pro Phe Leu Asn Leu Gln Thr Gly Gln Ser Leu Ala Leu Leu Ala 
            260                 265                 270         

Thr Leu Glu Leu Ser Ala Leu Ile Val Gly Ser Leu Val Ser Gly Tyr 
        275                 280                 285             

Leu Gln His Thr Ile Ser Ile Lys Thr Ala Leu Tyr Ala Ser Leu Val 
    290                 295                 300                 

Ile Gln Leu Leu Leu Leu Val Gly Phe Ala Thr Val Arg Phe Asp Trp 
305                 310                 315                 320 

Ile Leu Ile Phe Ser Thr Leu Asp Ala Phe Phe Ala Gly Val Leu Ser 
                325                 330                 335     

Pro Arg Leu Gln Glu Leu Val Phe Lys Gln Ile Pro Glu Glu Ser Met 
            340                 345                 350         

Gly Ala Val Gln Ser Ser Ile Gly Ala Ile Thr Val Val Leu Pro Ser 
        355                 360                 365             

Leu Phe Thr Ile Ala Leu Val Thr Ile Ala Thr Ser Phe Gly Thr Leu 
    370                 375                 380                 

Ala Val Ser Phe Val Leu Leu Leu Phe Leu Leu Val Ala Phe Val Met 
385                 390                 395                 400 

Leu Leu Asn Ile Arg Glu Ser Ile 
                405             

<210>   93
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   93
atgaaaatca aagagcaaac taggaaacta gccgcaggtt gctcaaaaca ctgttttgag   60
gttgcagata gaactgatga agtcagctca aaacactgtt ttgaggttgt ggatagaact   120
gacgaagtca gctcaaaaca ccgttttgag gttgtggata gaactgacga agtcagtaac   180
catacctacg gcaaagtgaa gctgacgtgg tttgaagaga gtttcgaaga gtacaag      237

<210>   94
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   94
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Arg 
        35                  40                  45              

Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Asn His Thr Tyr Gly 
    50                  55                  60                  

Lys Val Lys Leu Thr Trp Phe Glu Glu Ser Phe Glu Glu Tyr Lys 
65                  70                  75                  

<210>   95
<211>   654
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   95
atgccaacgg ctcttggcta tgtcagtatc ggcctggcct gtggaattat cggtgcgccc   60
tatgtgacac ctgttgagat gggcttgatg agtctctttg tttatgctgg gagtgcccag   120
tttgccatgt tggcactgat tgtggttcaa gctcctgtgg cagctattgc tatgacggtt   180
tttctaatca acttgcgtct ctttttgttg agtttacacg catcgactta tttccgtcat   240
accagtcttt ggtacaatat cggtatgtct agtatcttga cagatgagac ctatggcgtt   300
ttgatgggtg aattggccca tacagacaag gtaaatccta tgtggatgca cggaaacaat   360
cttaacagct atgtggcttg gtttgtgggg acagtagtcg gaacggctct gggtggcctg   420
ctaccaaatc cagaaatctt tggcttggat tttgccctgg ttgggatgtt tattggtatt   480
tttgcttcgc aatttcagat tatgcaaaga cggattcctg tccgcaatct gctcattatc   540
ctagcagttg ttgcggtgtc cttctttttg ctcttgacag tgatgtctca gtcactagct   600
gttctgtttg cgacgctact tggttgtagc atgggggtgg ttttagatgg tcag         654

<210>   96
<211>   218
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902189 (2.E-55)

<400>   96
Met Pro Thr Ala Leu Gly Tyr Val Ser Ile Gly Leu Ala Cys Gly Ile 

1               5                   10                  15      

Ile Gly Ala Pro Tyr Val Thr Pro Val Glu Met Gly Leu Met Ser Leu 
            20                  25                  30          

Phe Val Tyr Ala Gly Ser Ala Gln Phe Ala Met Leu Ala Leu Ile Val 
        35                  40                  45              

Val Gln Ala Pro Val Ala Ala Ile Ala Met Thr Val Phe Leu Ile Asn 
    50                  55                  60                  

Leu Arg Leu Phe Leu Leu Ser Leu His Ala Ser Thr Tyr Phe Arg His 
65                  70                  75                  80  

Thr Ser Leu Trp Tyr Asn Ile Gly Met Ser Ser Ile Leu Thr Asp Glu 
                85                  90                  95      

Thr Tyr Gly Val Leu Met Gly Glu Leu Ala His Thr Asp Lys Val Asn 
            100                 105                 110         

Pro Met Trp Met His Gly Asn Asn Leu Asn Ser Tyr Val Ala Trp Phe 
        115                 120                 125             

Val Gly Thr Val Val Gly Thr Ala Leu Gly Gly Leu Leu Pro Asn Pro 
    130                 135                 140                 

Glu Ile Phe Gly Leu Asp Phe Ala Leu Val Gly Met Phe Ile Gly Ile 
145                 150                 155                 160 

Phe Ala Ser Gln Phe Gln Ile Met Gln Arg Arg Ile Pro Val Arg Asn 
                165                 170                 175     

Leu Leu Ile Ile Leu Ala Val Val Ala Val Ser Phe Phe Leu Leu Leu 
            180                 185                 190         

Thr Val Met Ser Gln Ser Leu Ala Val Leu Phe Ala Thr Leu Leu Gly 
        195                 200                 205             

Cys Ser Met Gly Val Val Leu Asp Gly Gln 
    210                 215             

<210>   97
<211>   207
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   97
atggtcagta agtatctttt attagcagtt attttctctg gcttggtgac ttggattccc   60
cgtatgattc ccttcatctt ggtcaagtat aagggcctgc ctgcgattgt tgagcgtttt   120
ttgaagtttt tgcctgtttc cattatcttt gccctgattc tttcaagcgt agtgacaggt   180
aaggttggca gtcttcctca aatcaaa                                       207

<210>   98
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902189 (2.E-06)

<400>   98
Met Val Ser Lys Tyr Leu Leu Leu Ala Val Ile Phe Ser Gly Leu Val 
1               5                   10                  15      

Thr Trp Ile Pro Arg Met Ile Pro Phe Ile Leu Val Lys Tyr Lys Gly 
            20                  25                  30          

Leu Pro Ala Ile Val Glu Arg Phe Leu Lys Phe Leu Pro Val Ser Ile 
        35                  40                  45              

Ile Phe Ala Leu Ile Leu Ser Ser Val Val Thr Gly Lys Val Gly Ser 
    50                  55                  60                  

Leu Pro Gln Ile Lys 
65                  

<210>   99
<211>   828
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   99
atgaaaaaaa tcgttaaata ctcatctctt gcagcccttg ctcttgttgc tgcaggtgtg   60
cttgcggctt gctcaggggg tgctaagaaa gaaggagaag cagctagcaa gaaagaaatc   120
atcgttgcaa ccaatggatc accaaagcca tttatctatg aagaaaatgg cgaattgact   180
ggttacgaga ttgaagtcgt tcgcgctatc tttaaagatt ctgacaaata tgatgtcaag   240
tttgaaaaga cagaatggtc aggtgtcttt gctggtcttg acgctgatcg ttacaatatg   300
gctgtcaaca atcttagcta cactaaagaa cgtgcggaga aatacctcta tgccgcacca   360
attgcccaaa atcctaatgt ccttgtcgtg aagaaagatg actctagtat caagtctctc   420
gatgatatcg gtggaaaatc gacggaagtc gttcaagcca ctacatcagc taagcagtta   480
gaagcataca atgctgaaca cacggacaac ccaactatcc ttaactatac taaggcagac   540
ttgcaacaaa tcatggtacg tttgagcgat ggacaatttg actataagat ttttgataaa   600
atcggtgttg aaacagtgat caagaaccaa ggtttggaca acttgaaagt tatcgaactt   660
ccaagcgacc aacaaccgta cgtttaccca cttcttgctc agggtcaaga tgagttgaaa   720
tcgtttgtag acaaacgcat caaagaactt tataaagatg gaactcttga aaaattgtct   780
aaacaattct tcggagacac ttatctaccg gcagaagctg atattaaa                828

<210>   100
<211>   276
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, substrate-binding protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902190 (e-154)

<400>   100
Met Lys Lys Ile Val Lys Tyr Ser Ser Leu Ala Ala Leu Ala Leu Val 
1               5                   10                  15      

Ala Ala Gly Val Leu Ala Ala Cys Ser Gly Gly Ala Lys Lys Glu Gly 
            20                  25                  30          

Glu Ala Ala Ser Lys Lys Glu Ile Ile Val Ala Thr Asn Gly Ser Pro 
        35                  40                  45              

Lys Pro Phe Ile Tyr Glu Glu Asn Gly Glu Leu Thr Gly Tyr Glu Ile 
    50                  55                  60                  

Glu Val Val Arg Ala Ile Phe Lys Asp Ser Asp Lys Tyr Asp Val Lys 
65                  70                  75                  80  

Phe Glu Lys Thr Glu Trp Ser Gly Val Phe Ala Gly Leu Asp Ala Asp 
                85                  90                  95      

Arg Tyr Asn Met Ala Val Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala 
            100                 105                 110         

Glu Lys Tyr Leu Tyr Ala Ala Pro Ile Ala Gln Asn Pro Asn Val Leu 
        115                 120                 125             

Val Val Lys Lys Asp Asp Ser Ser Ile Lys Ser Leu Asp Asp Ile Gly 
    130                 135                 140                 

Gly Lys Ser Thr Glu Val Val Gln Ala Thr Thr Ser Ala Lys Gln Leu 
145                 150                 155                 160 

Glu Ala Tyr Asn Ala Glu His Thr Asp Asn Pro Thr Ile Leu Asn Tyr 
                165                 170                 175     

Thr Lys Ala Asp Leu Gln Gln Ile Met Val Arg Leu Ser Asp Gly Gln 
            180                 185                 190         

Phe Asp Tyr Lys Ile Phe Asp Lys Ile Gly Val Glu Thr Val Ile Lys 
        195                 200                 205             

Asn Gln Gly Leu Asp Asn Leu Lys Val Ile Glu Leu Pro Ser Asp Gln 
    210                 215                 220                 

Gln Pro Tyr Val Tyr Pro Leu Leu Ala Gln Gly Gln Asp Glu Leu Lys 
225                 230                 235                 240 

Ser Phe Val Asp Lys Arg Ile Lys Glu Leu Tyr Lys Asp Gly Thr Leu 
                245                 250                 255     

Glu Lys Leu Ser Lys Gln Phe Phe Gly Asp Thr Tyr Leu Pro Ala Glu 
            260                 265                 270         

Ala Asp Ile Lys 
        275     

<210>   101
<211>   852
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   101
atgaaaatca aaaaatggct tggtctagca gcccttgcta cagtcgcagg tttggctctt   60
gcagcttgcg gaaactcaga aaagaaagca gacaatgcaa caactatcaa aatcgcaact   120
gttaaccgta gcggttctga agaaaaacgt tgggacaaaa tccaagaatt ggttaaaaaa   180
gacggaatta ccttggaatt tacagagttc acagactact cacaaccaaa caaagcaact   240
gctgatggcg aagtagattt gaacgctttc caacactata acttcttgaa caactggaac   300
aaagaaaacg gaaaagacct tgtagcgatt gcagatactt acatctctcc aatccgcctt   360
tactcaggtt tgaatggaag tgccaacaag tacactaaag tagaagacat cccagcaaac   420
ggagaaatcg ctgtaccgaa tgacgctaca aacgaaagcc gtgcgcttta tttgcttcaa   480
tcagctggct tgattaaatt ggatgtttct ggaactgctc ttgcaacagt tgccaacatc   540
aaagaaaatc caaagaactt gaaaatcact gaattggacg ctagccaaac agctcgttca   600
ttgtcatcag ttgacgctgc cgttgtaaac aataccttcg ttacagaagc aaaattggac   660
tacaagaaat cacttttcaa agaacaagct gatgaaaact caaaacaatg gtacaacatc   720
attgttgcaa aaaaagattg ggaaacatca cctaaggctg atgctatcaa gaaagtaatc   780
gcagcttacc acacagatga cgtgaaaaaa gttatcgaag aatcatcaga tggtttggat   840
caaccagttt gg                                                       852

<210>   102
<211>   284
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   lipoprotein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902191 (e-161)

<400>   102
Met Lys Ile Lys Lys Trp Leu Gly Leu Ala Ala Leu Ala Thr Val Ala 
1               5                   10                  15      

Gly Leu Ala Leu Ala Ala Cys Gly Asn Ser Glu Lys Lys Ala Asp Asn 
            20                  25                  30          

Ala Thr Thr Ile Lys Ile Ala Thr Val Asn Arg Ser Gly Ser Glu Glu 
        35                  40                  45              

Lys Arg Trp Asp Lys Ile Gln Glu Leu Val Lys Lys Asp Gly Ile Thr 
    50                  55                  60                  

Leu Glu Phe Thr Glu Phe Thr Asp Tyr Ser Gln Pro Asn Lys Ala Thr 
65                  70                  75                  80  

Ala Asp Gly Glu Val Asp Leu Asn Ala Phe Gln His Tyr Asn Phe Leu 
                85                  90                  95      

Asn Asn Trp Asn Lys Glu Asn Gly Lys Asp Leu Val Ala Ile Ala Asp 
            100                 105                 110         

Thr Tyr Ile Ser Pro Ile Arg Leu Tyr Ser Gly Leu Asn Gly Ser Ala 
        115                 120                 125             

Asn Lys Tyr Thr Lys Val Glu Asp Ile Pro Ala Asn Gly Glu Ile Ala 
    130                 135                 140                 

Val Pro Asn Asp Ala Thr Asn Glu Ser Arg Ala Leu Tyr Leu Leu Gln 
145                 150                 155                 160 

Ser Ala Gly Leu Ile Lys Leu Asp Val Ser Gly Thr Ala Leu Ala Thr 
                165                 170                 175     

Val Ala Asn Ile Lys Glu Asn Pro Lys Asn Leu Lys Ile Thr Glu Leu 
            180                 185                 190         

Asp Ala Ser Gln Thr Ala Arg Ser Leu Ser Ser Val Asp Ala Ala Val 
        195                 200                 205             

Val Asn Asn Thr Phe Val Thr Glu Ala Lys Leu Asp Tyr Lys Lys Ser 
    210                 215                 220                 

Leu Phe Lys Glu Gln Ala Asp Glu Asn Ser Lys Gln Trp Tyr Asn Ile 
225                 230                 235                 240 

Ile Val Ala Lys Lys Asp Trp Glu Thr Ser Pro Lys Ala Asp Ala Ile 
                245                 250                 255     

Lys Lys Val Ile Ala Ala Tyr His Thr Asp Asp Val Lys Lys Val Ile 
            260                 265                 270         

Glu Glu Ser Ser Asp Gly Leu Asp Gln Pro Val Trp 
        275                 280                 

<210>   103
<211>   1371
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   103
atggtttttc ctagcgaaca agaacagatt gaaaaatttg aaaaggatca tgtagcccag   60
cattattttg aggttttgcg taccttgatt tctaagaaat cagtctttgc ccagcaggtt   120
ggactcaagg aagtcgcaaa ttatctgggt gagattttca agcgtgttgg agctgaagtg   180
gagattgatg agagctatac agcgcccttt gtcatggcac atttcaagag ttcgcgtcca   240
gatgccaaga ccttgatttt ctataaccac tatgacactg tgccagcgga tggggatcag   300
gtctggacag aggatccttt tacgctttcg gtccgcaatg gcttcatgta tgggcgtggg   360
gttgatgacg acaagggtca tatcacagct cgcttgagtg ctttgagaaa atatatgcag   420
caccatgatg atttacctgt caatatcagc tttatcatgg agggagcgga ggaatcggct   480
tcaacagacc tagataagta tttggaaaag catgcagaca aactccgtgg ggcggatttg   540
ttggtctggg aacaagggac caaaaatgcc ttggaacagc tggaaatttc tggtggcaat   600
aaggggattg tgacctttga tgccaaggta aaaagcgctg atgtggatat ccactcgagt   660
tatggtggtg ttgtggaatc agctccttgg tatctcctcc aagccttaca gtctcttcgt   720
gctgcggatg gccgtatctt ggttgaaggc ttgtacgaag aagtacaaga gcccaatgaa   780
cgagaaatgg ccttgctaga aacttatggt caacgaaacc cagaggaagt tagtcggatt   840
tatggattgg agttgcctct cttacaggag gagcggatgg cctttctaaa acgtttcttt   900
ttcgatccag cgcttaatat cgaaggaatc cagtctggtt atcaaggtca gggtgttaag   960
actattttac ctgcagaagc cagtgccaag ctagaggttc gtctggttcc gggcctagaa   1020
ccgcatgatg ttctggaaaa aattcggaaa cagctagaca aaaatggctt tgataaggta   1080
gaattatact ataccttggg agagatgagc tatcgaagcg atatgagcgc accagccatt   1140
ctcaatgtga tcgagttggc caagaaattc tatccacagg gcgtttcagt cttgccgacg   1200
acagcgggga caggacctat gcatacggtc tttgatgccc tagaggtacc aatggttgca   1260
ttcggtctag gaaatgccaa tagccgagac cacggtggag atgaaaatgt gcgaatcgct   1320
gattattaca cccatatcga attagtagag gagctgatta gaagctatga g            1371

<210>   104
<211>   457
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidase, M20/M25/M40 family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902192 (0.E+01)

<400>   104
Met Val Phe Pro Ser Glu Gln Glu Gln Ile Glu Lys Phe Glu Lys Asp 
1               5                   10                  15      

His Val Ala Gln His Tyr Phe Glu Val Leu Arg Thr Leu Ile Ser Lys 
            20                  25                  30          

Lys Ser Val Phe Ala Gln Gln Val Gly Leu Lys Glu Val Ala Asn Tyr 
        35                  40                  45              

Leu Gly Glu Ile Phe Lys Arg Val Gly Ala Glu Val Glu Ile Asp Glu 
    50                  55                  60                  

Ser Tyr Thr Ala Pro Phe Val Met Ala His Phe Lys Ser Ser Arg Pro 
65                  70                  75                  80  

Asp Ala Lys Thr Leu Ile Phe Tyr Asn His Tyr Asp Thr Val Pro Ala 
                85                  90                  95      

Asp Gly Asp Gln Val Trp Thr Glu Asp Pro Phe Thr Leu Ser Val Arg 
            100                 105                 110         

Asn Gly Phe Met Tyr Gly Arg Gly Val Asp Asp Asp Lys Gly His Ile 
        115                 120                 125             

Thr Ala Arg Leu Ser Ala Leu Arg Lys Tyr Met Gln His His Asp Asp 
    130                 135                 140                 

Leu Pro Val Asn Ile Ser Phe Ile Met Glu Gly Ala Glu Glu Ser Ala 
145                 150                 155                 160 

Ser Thr Asp Leu Asp Lys Tyr Leu Glu Lys His Ala Asp Lys Leu Arg 
                165                 170                 175     

Gly Ala Asp Leu Leu Val Trp Glu Gln Gly Thr Lys Asn Ala Leu Glu 
            180                 185                 190         

Gln Leu Glu Ile Ser Gly Gly Asn Lys Gly Ile Val Thr Phe Asp Ala 
        195                 200                 205             

Lys Val Lys Ser Ala Asp Val Asp Ile His Ser Ser Tyr Gly Gly Val 
    210                 215                 220                 

Val Glu Ser Ala Pro Trp Tyr Leu Leu Gln Ala Leu Gln Ser Leu Arg 
225                 230                 235                 240 

Ala Ala Asp Gly Arg Ile Leu Val Glu Gly Leu Tyr Glu Glu Val Gln 
                245                 250                 255     

Glu Pro Asn Glu Arg Glu Met Ala Leu Leu Glu Thr Tyr Gly Gln Arg 
            260                 265                 270         

Asn Pro Glu Glu Val Ser Arg Ile Tyr Gly Leu Glu Leu Pro Leu Leu 
        275                 280                 285             

Gln Glu Glu Arg Met Ala Phe Leu Lys Arg Phe Phe Phe Asp Pro Ala 
    290                 295                 300                 

Leu Asn Ile Glu Gly Ile Gln Ser Gly Tyr Gln Gly Gln Gly Val Lys 
305                 310                 315                 320 

Thr Ile Leu Pro Ala Glu Ala Ser Ala Lys Leu Glu Val Arg Leu Val 
                325                 330                 335     

Pro Gly Leu Glu Pro His Asp Val Leu Glu Lys Ile Arg Lys Gln Leu 
            340                 345                 350         

Asp Lys Asn Gly Phe Asp Lys Val Glu Leu Tyr Tyr Thr Leu Gly Glu 
        355                 360                 365             

Met Ser Tyr Arg Ser Asp Met Ser Ala Pro Ala Ile Leu Asn Val Ile 
    370                 375                 380                 

Glu Leu Ala Lys Lys Phe Tyr Pro Gln Gly Val Ser Val Leu Pro Thr 
385                 390                 395                 400 

Thr Ala Gly Thr Gly Pro Met His Thr Val Phe Asp Ala Leu Glu Val 
                405                 410                 415     

Pro Met Val Ala Phe Gly Leu Gly Asn Ala Asn Ser Arg Asp His Gly 
            420                 425                 430         

Gly Asp Glu Asn Val Arg Ile Ala Asp Tyr Tyr Thr His Ile Glu Leu 
        435                 440                 445             

Val Glu Glu Leu Ile Arg Ser Tyr Glu 
    450                 455         

<210>   105
<211>   1059

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   105
atgagtagag atattatcaa gttagatcag atcgatgtga cttttcacca aaagaagaga   60
accatcacag cggttaagga tgtgaccatt cacatccaag aaggggatat ctacggaatc   120
gttggatatt ctggagcagg aaaatcaacc cttgtacggg tgattaatct cttgcaaaaa   180
ccatctgcag ggaaaattac cattgacgac gatgtgattt ttgacggcaa ggtgaccttg   240
acggcagagc agttgcgtcg taaacgtcaa gatatcggaa tgattttcca gcattttaac   300
ctgatgagcc aaaagacagc agaggagaat gtagcctttg cccttaaaca ctctgaactc   360
agcaaggaag aaaagaaggc taaagtagct aagttgttgg acttggttgg tttggcagat   420
cgtgctgaaa actacccttc acaactatct ggagggcaaa aacagcgtgt ggcaattgcg   480
cgtgccttgg ccaatgatcc aaaaatcttg atttcagacg agtcaacttc tgcccttgat   540
ccgaagacaa ccaagcagat tttggccttg ttgcaagatt tgaaccaaaa attaggcttg   600
actgttgtct tgattacgca tgaaatgcag attgtcaaag acattgccaa ccgtgttgca   660
gttatgcagg atgggcattt gattgaagag ggtagtgtgc ttgaaatctt ctcaaaccct   720
aaacaacctt tgactcaaga ctttatctca acagctacag gtattgacga agccatggtc   780
aaaatcgaga agcaagaaat cgtggaacac ttgtctgaaa acagtctctt ggtgcaactc   840
aagtacgctg gagcttcaac agacgagcca cttttgaatg aattgtacaa gcattaccaa   900
gtaatggcta atattctcta tgggaatatc gaaattctcg atggtactcc tgttggagaa   960
ttggtggtgg ttttgtcagg tgaaaaagca gcgttggcag gtgcccaaga agccattcgt   1020
caagcaggtg tacaactaaa agtattgaag ggagtacag                          1059

<210>   106
<211>   353
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902193 (0.E+01)

<400>   106
Met Ser Arg Asp Ile Ile Lys Leu Asp Gln Ile Asp Val Thr Phe His 
1               5                   10                  15      

Gln Lys Lys Arg Thr Ile Thr Ala Val Lys Asp Val Thr Ile His Ile 
            20                  25                  30          

Gln Glu Gly Asp Ile Tyr Gly Ile Val Gly Tyr Ser Gly Ala Gly Lys 
        35                  40                  45              

Ser Thr Leu Val Arg Val Ile Asn Leu Leu Gln Lys Pro Ser Ala Gly 
    50                  55                  60                  

Lys Ile Thr Ile Asp Asp Asp Val Ile Phe Asp Gly Lys Val Thr Leu 
65                  70                  75                  80  

Thr Ala Glu Gln Leu Arg Arg Lys Arg Gln Asp Ile Gly Met Ile Phe 
                85                  90                  95      

Gln His Phe Asn Leu Met Ser Gln Lys Thr Ala Glu Glu Asn Val Ala 
            100                 105                 110         

Phe Ala Leu Lys His Ser Glu Leu Ser Lys Glu Glu Lys Lys Ala Lys 
        115                 120                 125             

Val Ala Lys Leu Leu Asp Leu Val Gly Leu Ala Asp Arg Ala Glu Asn 
    130                 135                 140                 

Tyr Pro Ser Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Ile Ala 
145                 150                 155                 160 

Arg Ala Leu Ala Asn Asp Pro Lys Ile Leu Ile Ser Asp Glu Ser Thr 
                165                 170                 175     

Ser Ala Leu Asp Pro Lys Thr Thr Lys Gln Ile Leu Ala Leu Leu Gln 
            180                 185                 190         

Asp Leu Asn Gln Lys Leu Gly Leu Thr Val Val Leu Ile Thr His Glu 
        195                 200                 205             

Met Gln Ile Val Lys Asp Ile Ala Asn Arg Val Ala Val Met Gln Asp 
    210                 215                 220                 

Gly His Leu Ile Glu Glu Gly Ser Val Leu Glu Ile Phe Ser Asn Pro 
225                 230                 235                 240 

Lys Gln Pro Leu Thr Gln Asp Phe Ile Ser Thr Ala Thr Gly Ile Asp 
                245                 250                 255     

Glu Ala Met Val Lys Ile Glu Lys Gln Glu Ile Val Glu His Leu Ser 
            260                 265                 270         

Glu Asn Ser Leu Leu Val Gln Leu Lys Tyr Ala Gly Ala Ser Thr Asp 
        275                 280                 285             

Glu Pro Leu Leu Asn Glu Leu Tyr Lys His Tyr Gln Val Met Ala Asn 
    290                 295                 300                 

Ile Leu Tyr Gly Asn Ile Glu Ile Leu Asp Gly Thr Pro Val Gly Glu 
305                 310                 315                 320 

Leu Val Val Val Leu Ser Gly Glu Lys Ala Ala Leu Ala Gly Ala Gln 
                325                 330                 335     

Glu Ala Ile Arg Gln Ala Gly Val Gln Leu Lys Val Leu Lys Gly Val 
            340                 345                 350         

Gln 
    

<210>   107
<211>   690
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   107
atggaatcat tgattcaaac ctatttacca aatgtctata agatgggttg ggctggtcag   60
gcaggctggg gaacggctat ctacttaact ctttatatga cagttctttc cttcattatc   120
ggaggcttct tggggctagt ggcaggtctc tttctcgtct tgacagcgcc aggtggtgtc   180
ttggagaata aagtcgtatt ctggatttta gacaaaatta cctcaatttt tcgtgcggtt   240
ccctttatca tcctcttggc aatcttgtca ccactttctc acttgattgt taaaacaagt   300
atcgggccaa atgcagccct tgtcccactt tcttttgcag tctttgcctt ctttgcccgt   360
caggtgcagg ttgtcttggc tgaattggat ggcggtgtca ttgaggcggc tcaagcgagc   420
ggagcgactt tctgggacat cgtgggtgtt tacctatcag aaggtcttcc agatttgatc   480
cgtgtgacga ctgtgacctt gatttccctt gttggggaaa cagctatggc cggtgcggtt   540
ggagctggtg gtatcggtaa cgtagccatc gcttatggat ttaaccgcta caatcacgat   600
gtgaccatct tggcaaccat tattatcatt ttgattatct ttgcaatcca attcttggga   660
gatttcttga ctaagaaatt gagccataaa                                    690

<210>   108
<211>   230
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902194 (e-127)

<400>   108
Met Glu Ser Leu Ile Gln Thr Tyr Leu Pro Asn Val Tyr Lys Met Gly 
1               5                   10                  15      

Trp Ala Gly Gln Ala Gly Trp Gly Thr Ala Ile Tyr Leu Thr Leu Tyr 
            20                  25                  30          

Met Thr Val Leu Ser Phe Ile Ile Gly Gly Phe Leu Gly Leu Val Ala 
        35                  40                  45              

Gly Leu Phe Leu Val Leu Thr Ala Pro Gly Gly Val Leu Glu Asn Lys 
    50                  55                  60                  

Val Val Phe Trp Ile Leu Asp Lys Ile Thr Ser Ile Phe Arg Ala Val 
65                  70                  75                  80  

Pro Phe Ile Ile Leu Leu Ala Ile Leu Ser Pro Leu Ser His Leu Ile 
                85                  90                  95      

Val Lys Thr Ser Ile Gly Pro Asn Ala Ala Leu Val Pro Leu Ser Phe 
            100                 105                 110         

Ala Val Phe Ala Phe Phe Ala Arg Gln Val Gln Val Val Leu Ala Glu 
        115                 120                 125             

Leu Asp Gly Gly Val Ile Glu Ala Ala Gln Ala Ser Gly Ala Thr Phe 
    130                 135                 140                 

Trp Asp Ile Val Gly Val Tyr Leu Ser Glu Gly Leu Pro Asp Leu Ile 
145                 150                 155                 160 

Arg Val Thr Thr Val Thr Leu Ile Ser Leu Val Gly Glu Thr Ala Met 
                165                 170                 175     

Ala Gly Ala Val Gly Ala Gly Gly Ile Gly Asn Val Ala Ile Ala Tyr 
            180                 185                 190         

Gly Phe Asn Arg Tyr Asn His Asp Val Thr Ile Leu Ala Thr Ile Ile 
        195                 200                 205             

Ile Ile Leu Ile Ile Phe Ala Ile Gln Phe Leu Gly Asp Phe Leu Thr 
    210                 215                 220                 

Lys Lys Leu Ser His Lys 
225                 230 

<210>   109
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   109
atgaagaaat ctatcttaac tacactgctt tttgcagttc tttacttcct ctgcatgggg   60
attggtgtcc ttttgggcaa tctctttgac caaactggaa acatgtttta tgcgcctgcc   120
tttactgccc ttgtcggcgg tagcgtctat atgatcctag tcgcaaaagt tccgcgcttt   180
ggagccatta ccactatcgg ccttgtcatt gccctctttt tcttgggaac taaacacggt   240
gctggttcct tccttcctgg aattatctgt ggcctcctag cagatggagt agctcattta   300
ggaaaataca aggacaaaac aaagaacttc ctttctttca ttattttcgc ctttagtaca   360
acaggaccaa tcttgcttat gtggattgcg cccaaagcct atatggctac tcttctggca   420
agaggaaaat cccaagaata tatcgaccgt atcatggtcg ctccaaaccc tggaactgtc   480
cttctattta tcgcaagtat tgtcatcgga gccctagtgg gtgccttgat tggacaagcc   540
ttgagtaaaa aatttgccca gaaaatc                                       567

<210>   110
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902195 (e-104)

<400>   110
Met Lys Lys Ser Ile Leu Thr Thr Leu Leu Phe Ala Val Leu Tyr Phe 
1               5                   10                  15      

Leu Cys Met Gly Ile Gly Val Leu Leu Gly Asn Leu Phe Asp Gln Thr 
            20                  25                  30          

Gly Asn Met Phe Tyr Ala Pro Ala Phe Thr Ala Leu Val Gly Gly Ser 
        35                  40                  45              

Val Tyr Met Ile Leu Val Ala Lys Val Pro Arg Phe Gly Ala Ile Thr 
    50                  55                  60                  

Thr Ile Gly Leu Val Ile Ala Leu Phe Phe Leu Gly Thr Lys His Gly 
65                  70                  75                  80  

Ala Gly Ser Phe Leu Pro Gly Ile Ile Cys Gly Leu Leu Ala Asp Gly 
                85                  90                  95      

Val Ala His Leu Gly Lys Tyr Lys Asp Lys Thr Lys Asn Phe Leu Ser 
            100                 105                 110         

Phe Ile Ile Phe Ala Phe Ser Thr Thr Gly Pro Ile Leu Leu Met Trp 
        115                 120                 125             

Ile Ala Pro Lys Ala Tyr Met Ala Thr Leu Leu Ala Arg Gly Lys Ser 
    130                 135                 140                 

Gln Glu Tyr Ile Asp Arg Ile Met Val Ala Pro Asn Pro Gly Thr Val 
145                 150                 155                 160 

Leu Leu Phe Ile Ala Ser Ile Val Ile Gly Ala Leu Val Gly Ala Leu 
                165                 170                 175     

Ile Gly Gln Ala Leu Ser Lys Lys Phe Ala Gln Lys Ile 
            180                 185                 

<210>   111
<211>   612
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   111
atgggtagat ttttagactt tgtctttaat cgtttctttt tagggatgat tgcgacagcc   60
ttcttttggc tattaacttt agcaggaggg attatccttg gtctagcgcc ggctagtgcc   120
accttgatga gcttatatgc agaacatggt tatagctttc gggaatacag tttgaaggag   180
gcttggtctc tttacaagca aaattttgtc tcaagcaacc tgattttcta tagcttttta   240
ggtgtgggtc tagttttgac ctatggtttg tatctcttgg tgcaattgcc tcatcagacc   300
attgttcatt tgattgcgac ccttttgaat gtcctagtag ttgccctgat ctttttggct   360
tatacagtat ctttaaaatt acaagtttat tttgccttgt cctatcgaaa tagtctcaaa   420
ttatccttga ttggcatctt tatgagtcta gcagctgtgg ctaaggttct ccttgggact   480
gtgctacttg tagcaattgg ttattatatg cctgccctgc tattttttgt aggaattggg   540
atgtggcatt tctttatcag tgatatgttg gaacctgtct atgaaatcat ccatgaaaaa   600
ttggcgacaa aa                                                       612

<210>   112
<211>   204
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902196 (e-113)

<400>   112
Met Gly Arg Phe Leu Asp Phe Val Phe Asn Arg Phe Phe Leu Gly Met 
1               5                   10                  15      

Ile Ala Thr Ala Phe Phe Trp Leu Leu Thr Leu Ala Gly Gly Ile Ile 
            20                  25                  30          

Leu Gly Leu Ala Pro Ala Ser Ala Thr Leu Met Ser Leu Tyr Ala Glu 
        35                  40                  45              

His Gly Tyr Ser Phe Arg Glu Tyr Ser Leu Lys Glu Ala Trp Ser Leu 
    50                  55                  60                  

Tyr Lys Gln Asn Phe Val Ser Ser Asn Leu Ile Phe Tyr Ser Phe Leu 
65                  70                  75                  80  

Gly Val Gly Leu Val Leu Thr Tyr Gly Leu Tyr Leu Leu Val Gln Leu 
                85                  90                  95      

Pro His Gln Thr Ile Val His Leu Ile Ala Thr Leu Leu Asn Val Leu 
            100                 105                 110         

Val Val Ala Leu Ile Phe Leu Ala Tyr Thr Val Ser Leu Lys Leu Gln 
        115                 120                 125             

Val Tyr Phe Ala Leu Ser Tyr Arg Asn Ser Leu Lys Leu Ser Leu Ile 
    130                 135                 140                 

Gly Ile Phe Met Ser Leu Ala Ala Val Ala Lys Val Leu Leu Gly Thr 
145                 150                 155                 160 

Val Leu Leu Val Ala Ile Gly Tyr Tyr Met Pro Ala Leu Leu Phe Phe 
                165                 170                 175     

Val Gly Ile Gly Met Trp His Phe Phe Ile Ser Asp Met Leu Glu Pro 
            180                 185                 190         

Val Tyr Glu Ile Ile His Glu Lys Leu Ala Thr Lys 
        195                 200                 

<210>   113
<211>   1701
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   113
gtgatatgtt ggaacctgtc tatgaaatca tccatgaaaa attggcgaca aaatagaatg   60
aagcagtttt ggctacatac gcttctaaga acctatagtt cagtgatgat cattatcatt   120
gcgagttttg caatcttact ctcttacgct gactgggatt cacgtgaaaa ggaagcccag   180
agagtagccc agcgtgtaac tgctagaaca gtgagtgaaa ttgaatatta ccatagagag   240
tcaacccaga tagctcaggc tttagttgaa aatcaagctc gtatcgaggg aatctataaa   300
tactttagcc ttagcatgcc agactatttt tactggcaat tagagcggaa agcttcgcct   360
tatatatcag tctctctgta tgaaaatgtt gatgacctct atgttcgaaa tgattttgta   420
actggggtgg ccattgcttt tcaagattac aaggaagtct atgtttctac taaagacaaa   480
cgtagtggag aaaaaatcag ggctgaggat ttcaaaccag caggaaatag ttttgccatt   540
ccagtgtcag atccagtgtc agatcaagac ttaggagtga tttacatctc cttggatcct   600
gctgttttat accatgccat tgataatact agaggtcata ctccgatggc agtaacagtg   660
acctcacctt ttgatacgga gatttttcat atgggtgaga cagttgataa ggagagtgaa   720
aattggctag ttggcttaac ttctcatgga tatcaggttc aggtggcagt tcctaaaaac   780
tttgttttac aaggaacagt gactagctct gctttgattg tgggtttgag ccttctcttt   840
attgtcattc tttatctgac tttgaggcag acttttgcta attaccaaaa gcaggtagtg   900
gatttagtag aatccattca agtcattgct caaggcgaag aggggcgtcg gattgacatt   960
tccgagaaag atcaggaatt actcctaatc gcggagacga ccaatgatat gttggatcga   1020
ttggaaaaga atatccatga tatttaccag ttagagctta gtcaaaaaga tgccaatatg   1080
cgagccttgc aggcgcaaat caatcctcat tttatgtata atacgctgga gttcttgcgc   1140
atgtatgcag ttatgcagag tcaagatgag ttggcagata tcatttatga attcagtagt   1200
ctcttgcgta acaatatttc cgacgaaaga gagaccctcc tcaaacagga attagaattt   1260
tgccgtaaat acagctatct ctgcatggtt cgctatccca agtccattgc ctatggtttc   1320
aagatagatc cagagttaga gaatatgaag attcccaagt ttaccttgca accgctggta   1380
gaaaactatt tcgcgcatgg tgttgaccac aggcggacag ataatgtgat tagcatcaag   1440
gctcttaaac aggatggttt tgtggaaatt ttggtggtcg ataatggtag aggaatgtcg   1500
gctgaaaagt tggcaaatat ccgagaaaaa ttaagtcaga gatattttga acaccaagcc   1560
agctacagtg atcaaaggca gtctatcggg attgtcaatg tacacgagcg ttttgtgctc   1620
tattttggag accgctatgc cattactata gagtctgcag agcaagccgg tgttcagtat   1680
cgtattacaa ttcaagatga g                                             1701

<210>   114
<211>   567
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902197 (e-130)

<400>   114
Met Ile Cys Trp Asn Leu Ser Met Lys Ser Ser Met Lys Asn Trp Arg 
1               5                   10                  15      

Gln Asn Arg Met Lys Gln Phe Trp Leu His Thr Leu Leu Arg Thr Tyr 
            20                  25                  30          

Ser Ser Val Met Ile Ile Ile Ile Ala Ser Phe Ala Ile Leu Leu Ser 
        35                  40                  45              

Tyr Ala Asp Trp Asp Ser Arg Glu Lys Glu Ala Gln Arg Val Ala Gln 

    50                  55                  60                  

Arg Val Thr Ala Arg Thr Val Ser Glu Ile Glu Tyr Tyr His Arg Glu 
65                  70                  75                  80  

Ser Thr Gln Ile Ala Gln Ala Leu Val Glu Asn Gln Ala Arg Ile Glu 
                85                  90                  95      

Gly Ile Tyr Lys Tyr Phe Ser Leu Ser Met Pro Asp Tyr Phe Tyr Trp 
            100                 105                 110         

Gln Leu Glu Arg Lys Ala Ser Pro Tyr Ile Ser Val Ser Leu Tyr Glu 
        115                 120                 125             

Asn Val Asp Asp Leu Tyr Val Arg Asn Asp Phe Val Thr Gly Val Ala 
    130                 135                 140                 

Ile Ala Phe Gln Asp Tyr Lys Glu Val Tyr Val Ser Thr Lys Asp Lys 
145                 150                 155                 160 

Arg Ser Gly Glu Lys Ile Arg Ala Glu Asp Phe Lys Pro Ala Gly Asn 
                165                 170                 175     

Ser Phe Ala Ile Pro Val Ser Asp Pro Val Ser Asp Gln Asp Leu Gly 
            180                 185                 190         

Val Ile Tyr Ile Ser Leu Asp Pro Ala Val Leu Tyr His Ala Ile Asp 
        195                 200                 205             

Asn Thr Arg Gly His Thr Pro Met Ala Val Thr Val Thr Ser Pro Phe 
    210                 215                 220                 

Asp Thr Glu Ile Phe His Met Gly Glu Thr Val Asp Lys Glu Ser Glu 
225                 230                 235                 240 

Asn Trp Leu Val Gly Leu Thr Ser His Gly Tyr Gln Val Gln Val Ala 
                245                 250                 255     

Val Pro Lys Asn Phe Val Leu Gln Gly Thr Val Thr Ser Ser Ala Leu 
            260                 265                 270         

Ile Val Gly Leu Ser Leu Leu Phe Ile Val Ile Leu Tyr Leu Thr Leu 
        275                 280                 285             

Arg Gln Thr Phe Ala Asn Tyr Gln Lys Gln Val Val Asp Leu Val Glu 
    290                 295                 300                 

Ser Ile Gln Val Ile Ala Gln Gly Glu Glu Gly Arg Arg Ile Asp Ile 
305                 310                 315                 320 

Ser Glu Lys Asp Gln Glu Leu Leu Leu Ile Ala Glu Thr Thr Asn Asp 
                325                 330                 335     

Met Leu Asp Arg Leu Glu Lys Asn Ile His Asp Ile Tyr Gln Leu Glu 
            340                 345                 350         

Leu Ser Gln Lys Asp Ala Asn Met Arg Ala Leu Gln Ala Gln Ile Asn 
        355                 360                 365             

Pro His Phe Met Tyr Asn Thr Leu Glu Phe Leu Arg Met Tyr Ala Val 
    370                 375                 380                 

Met Gln Ser Gln Asp Glu Leu Ala Asp Ile Ile Tyr Glu Phe Ser Ser 
385                 390                 395                 400 

Leu Leu Arg Asn Asn Ile Ser Asp Glu Arg Glu Thr Leu Leu Lys Gln 
                405                 410                 415     

Glu Leu Glu Phe Cys Arg Lys Tyr Ser Tyr Leu Cys Met Val Arg Tyr 
            420                 425                 430         

Pro Lys Ser Ile Ala Tyr Gly Phe Lys Ile Asp Pro Glu Leu Glu Asn 
        435                 440                 445             

Met Lys Ile Pro Lys Phe Thr Leu Gln Pro Leu Val Glu Asn Tyr Phe 
    450                 455                 460                 

Ala His Gly Val Asp His Arg Arg Thr Asp Asn Val Ile Ser Ile Lys 
465                 470                 475                 480 

Ala Leu Lys Gln Asp Gly Phe Val Glu Ile Leu Val Val Asp Asn Gly 
                485                 490                 495     

Arg Gly Met Ser Ala Glu Lys Leu Ala Asn Ile Arg Glu Lys Leu Ser 
            500                 505                 510         

Gln Arg Tyr Phe Glu His Gln Ala Ser Tyr Ser Asp Gln Arg Gln Ser 
        515                 520                 525             

Ile Gly Ile Val Asn Val His Glu Arg Phe Val Leu Tyr Phe Gly Asp 
    530                 535                 540                 

Arg Tyr Ala Ile Thr Ile Glu Ser Ala Glu Gln Ala Gly Val Gln Tyr 
545                 550                 555                 560 

Arg Ile Thr Ile Gln Asp Glu 
                565         

<210>   115
<211>   1284
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   115
atgtataaag tattattagt agatgatgag tacatggtga cagaaggtct gaagcgtttg   60
attccctttg ataagtggga tatggaggtc gtcgcaacag ccagtcatgc cgatgaagct   120
ctagaatatg ttcaggaaaa tcctgtcgat gtcatcattt ccgatgtcaa tatgccagac   180
aaaacagggc ttgatatgat tcgggagatg aaagagatct taccagatgc tgcctatatc   240
ctgctctcag gttatcagga gtttgattat gtaaaaagag caatgaacct tagtgtggtg   300
gactatttgg tcaagcctgt tgataaggta gagctgggaa atctgctgga gaagattgca   360
ggtcagctcg gcgagagagg gaagaaaagt cagactctta gtcaagaatt agacgaggct   420
ggatttgtta gttatttagg ggataaggag aattggtgga taggtctatc caaggaaaaa   480
caaggttcct tcaccattcc ctactatgtc ttgggtcaag actggcagat tttcatttct   540
ggccaccccc tagatggttt agtcgttaca ccttttgaag ctccttatca agaacacttt   600
gaacgctgga agctgaatgc tgagaaaacc ctcttttacg gttctgtaaa tctgcagcag   660
tctgagagtc tctttgccta ttacgaaccg atttataggg ttatcattca gggaaatctc   720
aatcaaatcg tagaagagtt aaatctcttg gagaaggtag ttcttgaaaa tacacctcgt   780
gtttcgatta ctaaacagct ttttatccag tttgtcatgg atgttttcca tttatttgaa   840
catctcaaag ctgatgatat gacggacatt gtcaaaacca ttcatgctat tcaatccttc   900
gatgaattgg tttcttatat caaggaaact ctgatcagct ttttcggtca ataccgtatg   960
aatgaaaatg tggtcagtgt gctggaagtc attggtcgtg attaccaaaa agagctttcc   1020
ctcaaggata tcagtaaggc cctctttatc aatcctgtct atctagggca gttgattaag   1080
cgtgaaaccg attcgacctt tgcagagtta ctaaacaaac aacgtattaa ggctgcccag   1140
cagctcttgc tttcaactag tgacagtatc gaagatattt gttatgctgt tggttacagt   1200
aaccttggat atttctataa agttttccga aaattgtgcg gaaaatcgcc aaaagcctac   1260
cgaaaacagg tagaaactat acta                                          1284

<210>   116
<211>   428
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902198 (0.E+01)

<400>   116
Met Tyr Lys Val Leu Leu Val Asp Asp Glu Tyr Met Val Thr Glu Gly 
1               5                   10                  15      

Leu Lys Arg Leu Ile Pro Phe Asp Lys Trp Asp Met Glu Val Val Ala 
            20                  25                  30          

Thr Ala Ser His Ala Asp Glu Ala Leu Glu Tyr Val Gln Glu Asn Pro 
        35                  40                  45              

Val Asp Val Ile Ile Ser Asp Val Asn Met Pro Asp Lys Thr Gly Leu 
    50                  55                  60                  

Asp Met Ile Arg Glu Met Lys Glu Ile Leu Pro Asp Ala Ala Tyr Ile 
65                  70                  75                  80  

Leu Leu Ser Gly Tyr Gln Glu Phe Asp Tyr Val Lys Arg Ala Met Asn 
                85                  90                  95      

Leu Ser Val Val Asp Tyr Leu Val Lys Pro Val Asp Lys Val Glu Leu 
            100                 105                 110         

Gly Asn Leu Leu Glu Lys Ile Ala Gly Gln Leu Gly Glu Arg Gly Lys 
        115                 120                 125             

Lys Ser Gln Thr Leu Ser Gln Glu Leu Asp Glu Ala Gly Phe Val Ser 
    130                 135                 140                 

Tyr Leu Gly Asp Lys Glu Asn Trp Trp Ile Gly Leu Ser Lys Glu Lys 
145                 150                 155                 160 

Gln Gly Ser Phe Thr Ile Pro Tyr Tyr Val Leu Gly Gln Asp Trp Gln 
                165                 170                 175     

Ile Phe Ile Ser Gly His Pro Leu Asp Gly Leu Val Val Thr Pro Phe 
            180                 185                 190         

Glu Ala Pro Tyr Gln Glu His Phe Glu Arg Trp Lys Leu Asn Ala Glu 
        195                 200                 205             

Lys Thr Leu Phe Tyr Gly Ser Val Asn Leu Gln Gln Ser Glu Ser Leu 
    210                 215                 220                 

Phe Ala Tyr Tyr Glu Pro Ile Tyr Arg Val Ile Ile Gln Gly Asn Leu 
225                 230                 235                 240 

Asn Gln Ile Val Glu Glu Leu Asn Leu Leu Glu Lys Val Val Leu Glu 
                245                 250                 255     

Asn Thr Pro Arg Val Ser Ile Thr Lys Gln Leu Phe Ile Gln Phe Val 
            260                 265                 270         

Met Asp Val Phe His Leu Phe Glu His Leu Lys Ala Asp Asp Met Thr 
        275                 280                 285             

Asp Ile Val Lys Thr Ile His Ala Ile Gln Ser Phe Asp Glu Leu Val 
    290                 295                 300                 

Ser Tyr Ile Lys Glu Thr Leu Ile Ser Phe Phe Gly Gln Tyr Arg Met 
305                 310                 315                 320 

Asn Glu Asn Val Val Ser Val Leu Glu Val Ile Gly Arg Asp Tyr Gln 
                325                 330                 335     

Lys Glu Leu Ser Leu Lys Asp Ile Ser Lys Ala Leu Phe Ile Asn Pro 
            340                 345                 350         

Val Tyr Leu Gly Gln Leu Ile Lys Arg Glu Thr Asp Ser Thr Phe Ala 
        355                 360                 365             

Glu Leu Leu Asn Lys Gln Arg Ile Lys Ala Ala Gln Gln Leu Leu Leu 
    370                 375                 380                 

Ser Thr Ser Asp Ser Ile Glu Asp Ile Cys Tyr Ala Val Gly Tyr Ser 
385                 390                 395                 400 

Asn Leu Gly Tyr Phe Tyr Lys Val Phe Arg Lys Leu Cys Gly Lys Ser 
                405                 410                 415     

Pro Lys Ala Tyr Arg Lys Gln Val Glu Thr Ile Leu 
            420                 425             

<210>   117
<211>   579
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   117
ttgtattcct ttacaaaagg tgctataata ttatcaggag gtcctatcat gaaaaagaaa   60
ccaatttatc tatgggtttt gctaatcttg tctgccctta tttcagttcc gtctctgttt   120
ggaattgtga gtcccttgcc tagtaaagaa gcccttcgtg ctgctcagaa acaagttgca   180
ggggtcaatg ctcagcaatt agaagaccag cttaattata cctatagagt agcagaagca   240
tctcattcta tttttaatgt tgctttgatt gtgctatcta ctattttagt ggtcgtagcg   300
attgtcttcc ttgttcgtaa aaatttgcaa tatgcaaact atacttacgt tggctatgtt   360
ttgttagcta ttattggttc gatttatggc tatgttggtt tacaagacgc tgtgcagttg   420
gttcaagatg agagcatgcg tttgacagtg agtattggtt caaaagctgt tagcattttc   480
tatatcgtca tcaatgttct cttcctagcc cttgtcttct ataagatgtg gcgacaacag   540
aaagccttgg cagaagaaga ggaaacagaa gagcttacc                          579

<210>   118
<211>   193
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902199 (e-102)

<400>   118
Met Tyr Ser Phe Thr Lys Gly Ala Ile Ile Leu Ser Gly Gly Pro Ile 
1               5                   10                  15      

Met Lys Lys Lys Pro Ile Tyr Leu Trp Val Leu Leu Ile Leu Ser Ala 
            20                  25                  30          

Leu Ile Ser Val Pro Ser Leu Phe Gly Ile Val Ser Pro Leu Pro Ser 
        35                  40                  45              

Lys Glu Ala Leu Arg Ala Ala Gln Lys Gln Val Ala Gly Val Asn Ala 
    50                  55                  60                  

Gln Gln Leu Glu Asp Gln Leu Asn Tyr Thr Tyr Arg Val Ala Glu Ala 
65                  70                  75                  80  

Ser His Ser Ile Phe Asn Val Ala Leu Ile Val Leu Ser Thr Ile Leu 
                85                  90                  95      

Val Val Val Ala Ile Val Phe Leu Val Arg Lys Asn Leu Gln Tyr Ala 
            100                 105                 110         

Asn Tyr Thr Tyr Val Gly Tyr Val Leu Leu Ala Ile Ile Gly Ser Ile 
        115                 120                 125             

Tyr Gly Tyr Val Gly Leu Gln Asp Ala Val Gln Leu Val Gln Asp Glu 
    130                 135                 140                 

Ser Met Arg Leu Thr Val Ser Ile Gly Ser Lys Ala Val Ser Ile Phe 
145                 150                 155                 160 

Tyr Ile Val Ile Asn Val Leu Phe Leu Ala Leu Val Phe Tyr Lys Met 
                165                 170                 175     

Trp Arg Gln Gln Lys Ala Leu Ala Glu Glu Glu Glu Thr Glu Glu Leu 
            180                 185                 190         

Thr 
    

<210>   119
<211>   600
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   119
gtggcgacaa cagaaagcct tggcagaaga agaggaaaca gaagagctta cctaagtatt   60
gacaaaaaag aactatcaag atacaatctt ggtagttgtt ttttgattat agataaaatc   120
atggaggtac atatgaagac aatttcttta gtttatatta gtttgagtgg caacactgaa   180
agttttgtga cgcgcttgaa agactatctc ttgtcccagt acaaagggat tgaggttcaa   240
aagattcata tcaaggattt ggtcaaggaa ggcaaaaatt tctatgaaat ggaccatccc   300
tatgtcgctt ttttgccgac ctatctcgaa ggtgggaatg gcgtggataa cggagatgtt   360
gagattttga cgacaccggt gggagatttt attgcctatg gtaacaatgc tagtaagtgt   420
tttggtgtgg ttgggtcagg aaatcgtaac tttaataacc aatactgcct aacagccaag   480
caatacagtc aacgctttgg cttccctgta ttggctgact ttgaaatgcg aggcatgctg   540
gaagatatca aacatgtcgc agctattatc gcagatttgt atgagttgga aaaggagaat   600

<210>   120
<211>   200
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   NrdI family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902200 (5.E-88)

<400>   120
Met Ala Thr Thr Glu Ser Leu Gly Arg Arg Arg Gly Asn Arg Arg Ala 
1               5                   10                  15      

Tyr Leu Ser Ile Asp Lys Lys Glu Leu Ser Arg Tyr Asn Leu Gly Ser 
            20                  25                  30          

Cys Phe Leu Ile Ile Asp Lys Ile Met Glu Val His Met Lys Thr Ile 
        35                  40                  45              

Ser Leu Val Tyr Ile Ser Leu Ser Gly Asn Thr Glu Ser Phe Val Thr 
    50                  55                  60                  

Arg Leu Lys Asp Tyr Leu Leu Ser Gln Tyr Lys Gly Ile Glu Val Gln 

65                  70                  75                  80  

Lys Ile His Ile Lys Asp Leu Val Lys Glu Gly Lys Asn Phe Tyr Glu 
                85                  90                  95      

Met Asp His Pro Tyr Val Ala Phe Leu Pro Thr Tyr Leu Glu Gly Gly 
            100                 105                 110         

Asn Gly Val Asp Asn Gly Asp Val Glu Ile Leu Thr Thr Pro Val Gly 
        115                 120                 125             

Asp Phe Ile Ala Tyr Gly Asn Asn Ala Ser Lys Cys Phe Gly Val Val 
    130                 135                 140                 

Gly Ser Gly Asn Arg Asn Phe Asn Asn Gln Tyr Cys Leu Thr Ala Lys 
145                 150                 155                 160 

Gln Tyr Ser Gln Arg Phe Gly Phe Pro Val Leu Ala Asp Phe Glu Met 
                165                 170                 175     

Arg Gly Met Leu Glu Asp Ile Lys His Val Ala Ala Ile Ile Ala Asp 
            180                 185                 190         

Leu Tyr Glu Leu Glu Lys Glu Asn 
        195                 200 

<210>   121
<211>   1260
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   121
atgtcgcaag ctatttcctt aaatcaatca acctgggcaa gcaagctaaa agcaatggga   60
cctggaatcc taatggcaac tgccgctgtt ggaggttccc acattgtatc ctcaactcaa   120
gctggcggtt cttacggttg gtctctactt ctcttggtca tcttagccaa tgtctttaaa   180
tatccatttt tccgttttgg tgctgaatac acagctgata ctggaaagac tttggttgaa   240
ggttatgccg aaaaaggaaa actctatctc tggattttct ttatcctcaa tgtcttttcg   300
gctatggtca acacggctgg tgttgccatt ctgtgctcag ctatcatcgc cagtgccttc   360
ccaatgattg gacttagcat tactcagtgg tccctcattc tcgttgcaat catttgggct   420
atgctactct ttggaggcta caaactttta gacggcatgg tcaaatggat tatgtctgcc   480
ttaaccattg cgactgttct tgcagttatc attgcggcgg tcaagcatcc agaatacagt   540
tctgattttg tcgagaagac accttggcaa atggcagctc tgcccttcat cgtctccctc   600
ctaggatgga tgccggctcc tattgaaatt tcagccatca attcactttg gtcagctgaa   660
aagagaaaga ccgtcaactt taacacagaa gacgctctgt ttgactttaa cactggttat   720
attggaacag ctatcctagc cgtcttcttt gtggcactgg gagcactgat tcagtatcct   780
acagggcagg cggttgaagc tgcttcagcc aaatacatct ctcaattcgt gggcatgtat   840
gcctctgttc ttggcgaatg gtcccgttac ttgattacct ttattgcctt cctctgtatc   900
tttggaacag ttataactgt tatcgatggc tattctcgcg ttaatcagga atctctccga   960
ctgctaatca gtcaaaaaga ggacaatcgt aaatctttga acatctggat gaccatcact   1020
gctatcatcg gtatcgtcat tatcaagttc ttcgctggtc aggtttcaac catgctccgc   1080
tttgccatga ttggctcttt cctgacaaca cctttctttg ctcttttgaa ttacgccttg   1140
gtaacgcgtg aaaacaaaaa tcttccttct tggctcaaac accttgccat tgcgggattg   1200
attttcctct ttggcttcgc catcttcttt atctacgcac tcgcaatcgg aaaagcaggg   1260

<210>   122
<211>   420
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902201 (0.E+01)

<400>   122
Met Ser Gln Ala Ile Ser Leu Asn Gln Ser Thr Trp Ala Ser Lys Leu 
1               5                   10                  15      

Lys Ala Met Gly Pro Gly Ile Leu Met Ala Thr Ala Ala Val Gly Gly 
            20                  25                  30          

Ser His Ile Val Ser Ser Thr Gln Ala Gly Gly Ser Tyr Gly Trp Ser 
        35                  40                  45              

Leu Leu Leu Leu Val Ile Leu Ala Asn Val Phe Lys Tyr Pro Phe Phe 
    50                  55                  60                  

Arg Phe Gly Ala Glu Tyr Thr Ala Asp Thr Gly Lys Thr Leu Val Glu 
65                  70                  75                  80  

Gly Tyr Ala Glu Lys Gly Lys Leu Tyr Leu Trp Ile Phe Phe Ile Leu 
                85                  90                  95      

Asn Val Phe Ser Ala Met Val Asn Thr Ala Gly Val Ala Ile Leu Cys 
            100                 105                 110         

Ser Ala Ile Ile Ala Ser Ala Phe Pro Met Ile Gly Leu Ser Ile Thr 
        115                 120                 125             

Gln Trp Ser Leu Ile Leu Val Ala Ile Ile Trp Ala Met Leu Leu Phe 
    130                 135                 140                 

Gly Gly Tyr Lys Leu Leu Asp Gly Met Val Lys Trp Ile Met Ser Ala 
145                 150                 155                 160 

Leu Thr Ile Ala Thr Val Leu Ala Val Ile Ile Ala Ala Val Lys His 
                165                 170                 175     

Pro Glu Tyr Ser Ser Asp Phe Val Glu Lys Thr Pro Trp Gln Met Ala 
            180                 185                 190         

Ala Leu Pro Phe Ile Val Ser Leu Leu Gly Trp Met Pro Ala Pro Ile 
        195                 200                 205             

Glu Ile Ser Ala Ile Asn Ser Leu Trp Ser Ala Glu Lys Arg Lys Thr 
    210                 215                 220                 

Val Asn Phe Asn Thr Glu Asp Ala Leu Phe Asp Phe Asn Thr Gly Tyr 
225                 230                 235                 240 

Ile Gly Thr Ala Ile Leu Ala Val Phe Phe Val Ala Leu Gly Ala Leu 
                245                 250                 255     

Ile Gln Tyr Pro Thr Gly Gln Ala Val Glu Ala Ala Ser Ala Lys Tyr 
            260                 265                 270         

Ile Ser Gln Phe Val Gly Met Tyr Ala Ser Val Leu Gly Glu Trp Ser 
        275                 280                 285             

Arg Tyr Leu Ile Thr Phe Ile Ala Phe Leu Cys Ile Phe Gly Thr Val 
    290                 295                 300                 

Ile Thr Val Ile Asp Gly Tyr Ser Arg Val Asn Gln Glu Ser Leu Arg 
305                 310                 315                 320 

Leu Leu Ile Ser Gln Lys Glu Asp Asn Arg Lys Ser Leu Asn Ile Trp 
                325                 330                 335     

Met Thr Ile Thr Ala Ile Ile Gly Ile Val Ile Ile Lys Phe Phe Ala 
            340                 345                 350         

Gly Gln Val Ser Thr Met Leu Arg Phe Ala Met Ile Gly Ser Phe Leu 
        355                 360                 365             

Thr Thr Pro Phe Phe Ala Leu Leu Asn Tyr Ala Leu Val Thr Arg Glu 
    370                 375                 380                 

Asn Lys Asn Leu Pro Ser Trp Leu Lys His Leu Ala Ile Ala Gly Leu 
385                 390                 395                 400 

Ile Phe Leu Phe Gly Phe Ala Ile Phe Phe Ile Tyr Ala Leu Ala Ile 
                405                 410                 415     

Gly Lys Ala Gly 
            420 

<210>   123
<211>   147
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   123
atgctccaag agttgattga tgtgatctac ttttttagcc tctcttttat agagaatagc   60
ccagatgatg agatagacaa tcgcaaactc gataatgagc tggaggtaga aaatccagtg   120
gaaagggaac caaccagcaa gagttgc                                       147

<210>   124
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   124
Met Leu Gln Glu Leu Ile Asp Val Ile Tyr Phe Phe Ser Leu Ser Phe 
1               5                   10                  15      

Ile Glu Asn Ser Pro Asp Asp Glu Ile Asp Asn Arg Lys Leu Asp Asn 
            20                  25                  30          

Glu Leu Glu Val Glu Asn Pro Val Glu Arg Glu Pro Thr Ser Lys Ser 
        35                  40                  45              

Cys 
    

<210>   125
<211>   456
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   125
atgaaaaaac aagtatttca cgatgcagct accggtgttc ttatcggcct catcctctct   60
atcctctttt cactcattta tgcaccaaat acctacgcac cactaaatcc ctactctctc   120
ataggccaag tgatggatca gcatcaggtt cacggtgccc tggtcttgct ctactgcaca   180
cttatctggg caaccatcgg tatgctcttc aactttggca accgcttatt tagccgtgac   240
tggagcatgc ttcgtgccac tctgactcat ttcttcctta tgctggctgg ctttgtccca   300
ctagcaactc ttgctggttg gttccctttc cactggattt tctacctcca gctcattatc   360
gagtttgcga ttgtctatct catcatctgg gctattctct ataaaagaga ggctaaaaaa   420
gtagatcaca tcaatcaact cttggagcat agaaaa                             456

<210>   126
<211>   152
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902202 (4.E-86)

<400>   126
Met Lys Lys Gln Val Phe His Asp Ala Ala Thr Gly Val Leu Ile Gly 
1               5                   10                  15      

Leu Ile Leu Ser Ile Leu Phe Ser Leu Ile Tyr Ala Pro Asn Thr Tyr 
            20                  25                  30          

Ala Pro Leu Asn Pro Tyr Ser Leu Ile Gly Gln Val Met Asp Gln His 
        35                  40                  45              

Gln Val His Gly Ala Leu Val Leu Leu Tyr Cys Thr Leu Ile Trp Ala 
    50                  55                  60                  

Thr Ile Gly Met Leu Phe Asn Phe Gly Asn Arg Leu Phe Ser Arg Asp 
65                  70                  75                  80  

Trp Ser Met Leu Arg Ala Thr Leu Thr His Phe Phe Leu Met Leu Ala 
                85                  90                  95      

Gly Phe Val Pro Leu Ala Thr Leu Ala Gly Trp Phe Pro Phe His Trp 
            100                 105                 110         

Ile Phe Tyr Leu Gln Leu Ile Ile Glu Phe Ala Ile Val Tyr Leu Ile 
        115                 120                 125             

Ile Trp Ala Ile Leu Tyr Lys Arg Glu Ala Lys Lys Val Asp His Ile 
    130                 135                 140                 

Asn Gln Leu Leu Glu His Arg Lys 
145                 150         

<210>   127
<211>   438
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   127
atgaaagtag aactacagat tagtgagact tacgaggagg aaaagctgat tgtccaagca   60
cctcaagaaa ccgaaaaagt ccagaaagtc atcgagttcg cagaaaatct ggaccaaaga   120
gaaaaaatca aaggaaaaat cgatgatcag gtctatctag ttgagattgg caagattcag   180
cgcttctata tcgagaatcg gaaggttcta gcagaaaccg cgagtcagac ctacagcatt   240
gatttgcgac tctatcaggt tcttaaactc ttgccaacca attttatcca aatttcccaa   300
tcagaaatca tcaatatcga ttccatctct cacctcaagc tcacgccaaa cggtctggta   360
gaaattttct tgaaaaacga aagcttcacc tactcttcac gccgttatct aaaaaccatc   420
aaggagaaat tagaacta                                                 438

<210>   128
<211>   146
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902203 (8.E-76)

<400>   128
Met Lys Val Glu Leu Gln Ile Ser Glu Thr Tyr Glu Glu Glu Lys Leu 
1               5                   10                  15      

Ile Val Gln Ala Pro Gln Glu Thr Glu Lys Val Gln Lys Val Ile Glu 
            20                  25                  30          

Phe Ala Glu Asn Leu Asp Gln Arg Glu Lys Ile Lys Gly Lys Ile Asp 
        35                  40                  45              

Asp Gln Val Tyr Leu Val Glu Ile Gly Lys Ile Gln Arg Phe Tyr Ile 
    50                  55                  60                  

Glu Asn Arg Lys Val Leu Ala Glu Thr Ala Ser Gln Thr Tyr Ser Ile 
65                  70                  75                  80  

Asp Leu Arg Leu Tyr Gln Val Leu Lys Leu Leu Pro Thr Asn Phe Ile 
                85                  90                  95      

Gln Ile Ser Gln Ser Glu Ile Ile Asn Ile Asp Ser Ile Ser His Leu 
            100                 105                 110         

Lys Leu Thr Pro Asn Gly Leu Val Glu Ile Phe Leu Lys Asn Glu Ser 
        115                 120                 125             

Phe Thr Tyr Ser Ser Arg Arg Tyr Leu Lys Thr Ile Lys Glu Lys Leu 
    130                 135                 140                 

Glu Leu 
145     

<210>   129
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   129
ttgtctatgt ggagggattg ggctcctatg tggtggagct tttctgttct ttctgaaata   60
tggtataata gcactaatca atttctagga aaa                                93

<210>   130
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   130
Met Ser Met Trp Arg Asp Trp Ala Pro Met Trp Trp Ser Phe Ser Val 
1               5                   10                  15      

Leu Ser Glu Ile Trp Tyr Asn Ser Thr Asn Gln Phe Leu Gly Lys 
            20                  25                  30      

<210>   131
<211>   864
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   131

gtgggcacac tattagcaac aagattaaaa aatagacgga aagaattaaa aatgtctcag   60
cgagaactag ctgaaggtat ctgtaaacag gggcaaatca gtcgattaga gagcggagag   120
tttacccctg gagcggattt cctgaatgcc cttgctaaga agttaaaagt cagtatggat   180
tatttttttg atgagcaggt tgtagagaaa gttgaggagt tatcagaatt taagaaatta   240
gcacagacat ttattacaaa tcgcaattat gagtctttga aatatatata tgaattggag   300
aatgtaaaag ctcaccgcct atctttagca gataaaatct acatggaatg gataaaatct   360
ctgatagatt tttattttta cggacagaaa gaagatgcga ttgtacgatt agagggggta   420
ttatcacagt taagtgtatc tgatttgaac tatctccaag tttcaaacac cctattcaat   480
ttttattatg atattggaga tttaggtcgt ttcaataaaa ttcgtgaaaa actagagtat   540
caagtaaatc acctcaattt gagtacaatc gaagagttag aactatctat taagtttaac   600
tacaacgttt gtcgttatct atggttacag aaaaatattg aagaagctat tactaaaatt   660
acagctacta taaaacaatg taaggcttac agaacgaatt atcttttggc tgatttgtac   720
ttattgatgg gaaatgtaag tgaaaatttt tcttctaaaa gttcggtgaa agaatatttt   780
gagacggcat attttctata caaacttgag gagaacatgt caatgactct gaaagttgag   840
cattacattg cagatataac agaa                                          864

<210>   132
<211>   288
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator PlcR, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903805 (2.E-55)

<400>   132
Met Gly Thr Leu Leu Ala Thr Arg Leu Lys Asn Arg Arg Lys Glu Leu 
1               5                   10                  15      

Lys Met Ser Gln Arg Glu Leu Ala Glu Gly Ile Cys Lys Gln Gly Gln 
            20                  25                  30          

Ile Ser Arg Leu Glu Ser Gly Glu Phe Thr Pro Gly Ala Asp Phe Leu 
        35                  40                  45              

Asn Ala Leu Ala Lys Lys Leu Lys Val Ser Met Asp Tyr Phe Phe Asp 
    50                  55                  60                  

Glu Gln Val Val Glu Lys Val Glu Glu Leu Ser Glu Phe Lys Lys Leu 
65                  70                  75                  80  

Ala Gln Thr Phe Ile Thr Asn Arg Asn Tyr Glu Ser Leu Lys Tyr Ile 
                85                  90                  95      

Tyr Glu Leu Glu Asn Val Lys Ala His Arg Leu Ser Leu Ala Asp Lys 
            100                 105                 110         

Ile Tyr Met Glu Trp Ile Lys Ser Leu Ile Asp Phe Tyr Phe Tyr Gly 
        115                 120                 125             

Gln Lys Glu Asp Ala Ile Val Arg Leu Glu Gly Val Leu Ser Gln Leu 
    130                 135                 140                 

Ser Val Ser Asp Leu Asn Tyr Leu Gln Val Ser Asn Thr Leu Phe Asn 
145                 150                 155                 160 

Phe Tyr Tyr Asp Ile Gly Asp Leu Gly Arg Phe Asn Lys Ile Arg Glu 
                165                 170                 175     

Lys Leu Glu Tyr Gln Val Asn His Leu Asn Leu Ser Thr Ile Glu Glu 
            180                 185                 190         

Leu Glu Leu Ser Ile Lys Phe Asn Tyr Asn Val Cys Arg Tyr Leu Trp 
        195                 200                 205             

Leu Gln Lys Asn Ile Glu Glu Ala Ile Thr Lys Ile Thr Ala Thr Ile 
    210                 215                 220                 

Lys Gln Cys Lys Ala Tyr Arg Thr Asn Tyr Leu Leu Ala Asp Leu Tyr 
225                 230                 235                 240 

Leu Leu Met Gly Asn Val Ser Glu Asn Phe Ser Ser Lys Ser Ser Val 
                245                 250                 255     

Lys Glu Tyr Phe Glu Thr Ala Tyr Phe Leu Tyr Lys Leu Glu Glu Asn 
            260                 265                 270         

Met Ser Met Thr Leu Lys Val Glu His Tyr Ile Ala Asp Ile Thr Glu 
        275                 280                 285             


<210>   133
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   133
atgagaagtt tgtttaagaa aatagttgct gtattagtta ttggcttaat tctgttagga   60
attgcgagaa cacctcaagt tcataagatg gctagaggga ttgatcctgg tcctgcgaat   120
tttatt                                                              126

<210>   134
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside

<400>   134
Met Arg Ser Leu Phe Lys Lys Ile Val Ala Val Leu Val Ile Gly Leu 
1               5                   10                  15      

Ile Leu Leu Gly Ile Ala Arg Thr Pro Gln Val His Lys Met Ala Arg 
            20                  25                  30          

Gly Ile Asp Pro Gly Pro Ala Asn Phe Ile 
        35                  40          

<210>   135
<211>   555
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   135
atggataaga aaaatttact tgtattggtt actggttcgg taggtgccag taatgtagat   60
acatacttat attacataaa aaaattctat aatgttaaag tgatactttc tgaaaattct   120
aaaaaattta taagtaagga attaattagt tatttttgtg ataaagttta tgatgaaata   180
tttgttgaag aggtagttcc gcacgttttt ctgccatatg aatctgactt acttcttatt   240
ttaccagcta cggcaaatgt gattggcaaa attgctaatg gtattgctga tgatttagtt   300
acagcaactg ttttaaactt taataaaaaa ataatttttt gtcccaatat gaactctact   360
atgtgggaca atcacatagt tcaaagaaat gtatcaattc taaaggagtt gggacatata   420
tttttatttg agtctaaaaa aacatatgag gtaggattgc gtaaagcaat agattcaaca   480
tgttcaatgt tacaaccaca gtcgttagta aaagaactta tcaaattaga aaatattgtc   540
cttgaagagg gacat                                                    555

<210>   136
<211>   185
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   flavoprotein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903154 (1.E-14)

<400>   136
Met Asp Lys Lys Asn Leu Leu Val Leu Val Thr Gly Ser Val Gly Ala 
1               5                   10                  15      

Ser Asn Val Asp Thr Tyr Leu Tyr Tyr Ile Lys Lys Phe Tyr Asn Val 
            20                  25                  30          

Lys Val Ile Leu Ser Glu Asn Ser Lys Lys Phe Ile Ser Lys Glu Leu 
        35                  40                  45              

Ile Ser Tyr Phe Cys Asp Lys Val Tyr Asp Glu Ile Phe Val Glu Glu 
    50                  55                  60                  

Val Val Pro His Val Phe Leu Pro Tyr Glu Ser Asp Leu Leu Leu Ile 
65                  70                  75                  80  

Leu Pro Ala Thr Ala Asn Val Ile Gly Lys Ile Ala Asn Gly Ile Ala 
                85                  90                  95      

Asp Asp Leu Val Thr Ala Thr Val Leu Asn Phe Asn Lys Lys Ile Ile 
            100                 105                 110         

Phe Cys Pro Asn Met Asn Ser Thr Met Trp Asp Asn His Ile Val Gln 
        115                 120                 125             

Arg Asn Val Ser Ile Leu Lys Glu Leu Gly His Ile Phe Leu Phe Glu 
    130                 135                 140                 

Ser Lys Lys Thr Tyr Glu Val Gly Leu Arg Lys Ala Ile Asp Ser Thr 
145                 150                 155                 160 

Cys Ser Met Leu Gln Pro Gln Ser Leu Val Lys Glu Leu Ile Lys Leu 
                165                 170                 175     

Glu Asn Ile Val Leu Glu Glu Gly His 
            180                 185 

<210>   137
<211>   1104
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   137
atgattaata aaaaaataca acaagttgtt ttggaatcat tacagaattt tttgaatggg   60
aacttcattt cgccttgtgt agtctatgat tttggcttgc tggaaactgt acttgatgaa   120
tttaaaaatc aaattcctgt aacattcaat taccaacttt tttatgccgt taaagcaaat   180
tcaaatgaga agatacttga attcttagta gataaaattg atggagttga tgtggcgtca   240
ttatctgaat tagatgtggc taaaaaattt ttcccaccaa ctcaaatttc tgttaatggt   300
cccgcatttt cttatgaaac tttatataat ctgattaaaa aacaatataa agttgatatt   360
aactttttgg aacatcttca acaattttcc ccaaaagaat ctgttggaat aagagtaacg   420
gagccagatg aacttaataa tcgtatgagt cgatttggaa taaatatttg cagtgataat   480
tggactagta atttacaaaa tcctttaatt acacgactgc attttcattt tggagaaaaa   540

gatgataaat ttattgttaa gttagataaa atattattta agttacaaga aattaataaa   600
cttagagagg ttagagaaat aaatcttgga ggcggtttta tgaaattatt tatggaaaat   660
cgtttgaaag aattttttct atcacttatg gaaatctata aaaagtacga tattgatagt   720
actgtgacta caataataga accaggtagt gcaattactt cattttctgc ctatatgatt   780
actagcccag ttaatgttag tgaggtgaat gagcagcagg ttatcacgtt agacacatca   840
atatacacca atacattatg gtttgttccg catattatta caacgttaaa ttcaagtagt   900
aaagagcgtt atagtactat tctctatggt aatacctgtt atgaacatga caagtataaa   960
atgaaagttt cgcttccaag gttaactcaa aatagcagta tagtgttttt tcctgtagga   1020
gcttatataa aaagcaatca ttcaaattta catcgtaatg attttatgcg ggaggtatat   1080
ttgtggacaa aaaacttgac atat                                          1104

<210>   138
<211>   368
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyridoxal-dependent decarboxylase, Orn/Lys/Arg family
<223>   Cellular location: cytoplasm

<400>   138
Met Ile Asn Lys Lys Ile Gln Gln Val Val Leu Glu Ser Leu Gln Asn 
1               5                   10                  15      

Phe Leu Asn Gly Asn Phe Ile Ser Pro Cys Val Val Tyr Asp Phe Gly 
            20                  25                  30          

Leu Leu Glu Thr Val Leu Asp Glu Phe Lys Asn Gln Ile Pro Val Thr 
        35                  40                  45              

Phe Asn Tyr Gln Leu Phe Tyr Ala Val Lys Ala Asn Ser Asn Glu Lys 
    50                  55                  60                  

Ile Leu Glu Phe Leu Val Asp Lys Ile Asp Gly Val Asp Val Ala Ser 
65                  70                  75                  80  

Leu Ser Glu Leu Asp Val Ala Lys Lys Phe Phe Pro Pro Thr Gln Ile 
                85                  90                  95      

Ser Val Asn Gly Pro Ala Phe Ser Tyr Glu Thr Leu Tyr Asn Leu Ile 
            100                 105                 110         

Lys Lys Gln Tyr Lys Val Asp Ile Asn Phe Leu Glu His Leu Gln Gln 
        115                 120                 125             

Phe Ser Pro Lys Glu Ser Val Gly Ile Arg Val Thr Glu Pro Asp Glu 
    130                 135                 140                 

Leu Asn Asn Arg Met Ser Arg Phe Gly Ile Asn Ile Cys Ser Asp Asn 
145                 150                 155                 160 

Trp Thr Ser Asn Leu Gln Asn Pro Leu Ile Thr Arg Leu His Phe His 
                165                 170                 175     

Phe Gly Glu Lys Asp Asp Lys Phe Ile Val Lys Leu Asp Lys Ile Leu 
            180                 185                 190         

Phe Lys Leu Gln Glu Ile Asn Lys Leu Arg Glu Val Arg Glu Ile Asn 
        195                 200                 205             

Leu Gly Gly Gly Phe Met Lys Leu Phe Met Glu Asn Arg Leu Lys Glu 
    210                 215                 220                 

Phe Phe Leu Ser Leu Met Glu Ile Tyr Lys Lys Tyr Asp Ile Asp Ser 
225                 230                 235                 240 

Thr Val Thr Thr Ile Ile Glu Pro Gly Ser Ala Ile Thr Ser Phe Ser 
                245                 250                 255     

Ala Tyr Met Ile Thr Ser Pro Val Asn Val Ser Glu Val Asn Glu Gln 
            260                 265                 270         

Gln Val Ile Thr Leu Asp Thr Ser Ile Tyr Thr Asn Thr Leu Trp Phe 
        275                 280                 285             

Val Pro His Ile Ile Thr Thr Leu Asn Ser Ser Ser Lys Glu Arg Tyr 
    290                 295                 300                 

Ser Thr Ile Leu Tyr Gly Asn Thr Cys Tyr Glu His Asp Lys Tyr Lys 
305                 310                 315                 320 

Met Lys Val Ser Leu Pro Arg Leu Thr Gln Asn Ser Ser Ile Val Phe 
                325                 330                 335     

Phe Pro Val Gly Ala Tyr Ile Lys Ser Asn His Ser Asn Leu His Arg 
            340                 345                 350         

Asn Asp Phe Met Arg Glu Val Tyr Leu Trp Thr Lys Asn Leu Thr Tyr 
        355                 360                 365             


<210>   139
<211>   1389
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   139
gtggacaaaa aacttgacat attagataaa gttaaggaat atttaggaaa taaaactact   60
caaattctgg ataatcaata taaagaattt ttgaaactta atgatataag gcgagcgttt   120
ggtatttcag aaaaagtatt aaacaattct tttaatttta cgagtaaaga atttaatgat   180
ttaattaata acgaaaatta tttattcgaa tatgcatgta gaattagaga ggaatggaga   240
aaaaaatgct ttaatcattc ttatcgtttt ctatgctcac ctataattac agatgatttt   300
cttaacacga agacattgag aagtagccaa attgaatata aatatgagcg atatttatcg   360
aaaagttcga taggcgatag agcggttgat ggctttgttt ccttcaatac tttaacagct   420
aatggtatgt ctgctattaa actatgtctt gagatattaa actctatttt cttcaagaag   480
aagattgatt tattatattc aaccggatat tatgaaacaa gatttttatt aaataatctt   540
gctaaatcag gtattagttg ctatgaggta agtaattgtg aattggataa agataaattt   600
tataatgtat tcatgatgga acccaatcga gccgatttaa cattacaaaa aactgatttc   660
aagatagtag aatattttgt taagtataaa aataattcaa taaaagtcgt tattttagat   720
atttcatatc aaggttctaa ttttaaatta gtagaatttt tagagaaatt taaatttgcg   780
aatgtaatta tttttgtggt acgatctttg ataaaattag atcaaatggg attagaattg   840
acaaatgggg gaataataga agtgtttatt cctaatcatt tgagaaagtt gaaaaatttt   900
attgaagagg aattcaataa atttagaaat tctcacggag ctaatctaag cctctatgaa   960
tactgtttgc ttgataattc tttaacttta aaaaatgatt ggaactattc tgatttagtt   1020
atgaaattta cgagtaattt ttatgctgat ataaaagact tgttcatgga aaattctgat   1080
attgaaatca tccatgaaga gggagtacct tttgtatttt tagatttaat aggtgaaggt   1140
aaaaaagaat atgaaatgtt ttttcaatgg ttaaacttct tttacaaaca gcttggaatc   1200
acattgtatg ctagaaatag ttttgggttt cggaatctaa cagtagagta ttttggaatt   1260
attgggacag aaagatatat atttaagatt tgtccaggtg tttataaagg gttaagttat   1320
tatttgatga aatttttatt aaaatctttt tcaaatgaat atttaaaaac tactgatgag   1380
gttaataga                                                           1389

<210>   140
<211>   463
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   140
Met Asp Lys Lys Leu Asp Ile Leu Asp Lys Val Lys Glu Tyr Leu Gly 
1               5                   10                  15      

Asn Lys Thr Thr Gln Ile Leu Asp Asn Gln Tyr Lys Glu Phe Leu Lys 
            20                  25                  30          

Leu Asn Asp Ile Arg Arg Ala Phe Gly Ile Ser Glu Lys Val Leu Asn 
        35                  40                  45              

Asn Ser Phe Asn Phe Thr Ser Lys Glu Phe Asn Asp Leu Ile Asn Asn 
    50                  55                  60                  

Glu Asn Tyr Leu Phe Glu Tyr Ala Cys Arg Ile Arg Glu Glu Trp Arg 
65                  70                  75                  80  

Lys Lys Cys Phe Asn His Ser Tyr Arg Phe Leu Cys Ser Pro Ile Ile 
                85                  90                  95      

Thr Asp Asp Phe Leu Asn Thr Lys Thr Leu Arg Ser Ser Gln Ile Glu 
            100                 105                 110         

Tyr Lys Tyr Glu Arg Tyr Leu Ser Lys Ser Ser Ile Gly Asp Arg Ala 
        115                 120                 125             

Val Asp Gly Phe Val Ser Phe Asn Thr Leu Thr Ala Asn Gly Met Ser 
    130                 135                 140                 

Ala Ile Lys Leu Cys Leu Glu Ile Leu Asn Ser Ile Phe Phe Lys Lys 
145                 150                 155                 160 

Lys Ile Asp Leu Leu Tyr Ser Thr Gly Tyr Tyr Glu Thr Arg Phe Leu 
                165                 170                 175     

Leu Asn Asn Leu Ala Lys Ser Gly Ile Ser Cys Tyr Glu Val Ser Asn 
            180                 185                 190         

Cys Glu Leu Asp Lys Asp Lys Phe Tyr Asn Val Phe Met Met Glu Pro 
        195                 200                 205             

Asn Arg Ala Asp Leu Thr Leu Gln Lys Thr Asp Phe Lys Ile Val Glu 
    210                 215                 220                 

Tyr Phe Val Lys Tyr Lys Asn Asn Ser Ile Lys Val Val Ile Leu Asp 
225                 230                 235                 240 

Ile Ser Tyr Gln Gly Ser Asn Phe Lys Leu Val Glu Phe Leu Glu Lys 
                245                 250                 255     

Phe Lys Phe Ala Asn Val Ile Ile Phe Val Val Arg Ser Leu Ile Lys 
            260                 265                 270         

Leu Asp Gln Met Gly Leu Glu Leu Thr Asn Gly Gly Ile Ile Glu Val 
        275                 280                 285             

Phe Ile Pro Asn His Leu Arg Lys Leu Lys Asn Phe Ile Glu Glu Glu 
    290                 295                 300                 

Phe Asn Lys Phe Arg Asn Ser His Gly Ala Asn Leu Ser Leu Tyr Glu 
305                 310                 315                 320 

Tyr Cys Leu Leu Asp Asn Ser Leu Thr Leu Lys Asn Asp Trp Asn Tyr 
                325                 330                 335     

Ser Asp Leu Val Met Lys Phe Thr Ser Asn Phe Tyr Ala Asp Ile Lys 
            340                 345                 350         

Asp Leu Phe Met Glu Asn Ser Asp Ile Glu Ile Ile His Glu Glu Gly 
        355                 360                 365             

Val Pro Phe Val Phe Leu Asp Leu Ile Gly Glu Gly Lys Lys Glu Tyr 
    370                 375                 380                 

Glu Met Phe Phe Gln Trp Leu Asn Phe Phe Tyr Lys Gln Leu Gly Ile 
385                 390                 395                 400 

Thr Leu Tyr Ala Arg Asn Ser Phe Gly Phe Arg Asn Leu Thr Val Glu 
                405                 410                 415     

Tyr Phe Gly Ile Ile Gly Thr Glu Arg Tyr Ile Phe Lys Ile Cys Pro 
            420                 425                 430         

Gly Val Tyr Lys Gly Leu Ser Tyr Tyr Leu Met Lys Phe Leu Leu Lys 
        435                 440                 445             

Ser Phe Ser Asn Glu Tyr Leu Lys Thr Thr Asp Glu Val Asn Arg 
    450                 455                 460             

<210>   141
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   141
atggagctag ccattactga aataaacact agactcatta tcacccaaaa tgatatttgg   60
tttaataata ataaaaatat tacagccact gctaat                             96

<210>   142
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   142
Met Glu Leu Ala Ile Thr Glu Ile Asn Thr Arg Leu Ile Ile Thr Gln 
1               5                   10                  15      

Asn Asp Ile Trp Phe Asn Asn Asn Lys Asn Ile Thr Ala Thr Ala Asn 
            20                  25                  30          


<210>   143
<211>   1176
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   143
atgaaaaatt tgataaagtt gctaataatt agattgattg ttaacttagc agacagtgta   60
ttttatatag tagcattgtg gcacgttagc aataattatt cttcgagcat gttcttagga   120
atatttattg cagtaaatta tctaccggat ttgttactaa tcttttttgg accagttatt   180
gacagagtaa atccgcaaaa aattcttata atatcaattt tggttcaatt agcagtggct   240
gtaatatttt tattattatt aaaccaaata tcattttggg tgataatgag tctagtgttt   300
atttcagtaa tggctagctc cataagttac gtgatagaag atgtgttgat tcctcaagtg   360
gtagaatatg ataagattgt atttgcaaat tctcttttta gtatttcgta taaagtatta   420
gattctattt ttaattcatt cgcatcattt ttacaggtgg cagtaggatt tattttattg   480
gttaagatag atataggcat atttttactt gctctattta tattgttgtt gttaaaattt   540
agaactagca atgcgaatat agaaaacttc tctttcaaat attacaagag agaagtgttg   600
caaggtacaa agtttatttt aaataataaa ttattattta aaaccagtat ttctttaacg   660
cttataaact ttttttattc atttcagaca gtagttgtac cgattttttc tattcgatat   720
tttgatggtc cgatttttta tggtattttt ttaactattg ctggtttggg tggtatattg   780
ggaaatatgc tagcgccaat cgtaataaaa tatttaaaat cgaatcaaat tgttggtgta   840
tttctttttt tgaacggctc aagttggtta gtagcaattg ttataaaaga ctatacttta   900
tcacttattt tatttttcgt ttgttttatg tctaaaggag tcttcaatat tatttttaat   960
tcgttgtacc aacaaatacc tccacatcaa cttcttggta gggtaaatac taccattgat   1020
tctattattt cttttggaat gccaattggt agtttagttg caggaacgct tattgatttg   1080
aatattgaat tagtgttaat tgctattagc ataccttatt ttttgttttc ttatattttt   1140
tatacggata atggattgaa agaatttagt atatat                             1176

<210>   144
<211>   392
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   macrolide efflux protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903015 (2.E-20)

<400>   144
Met Lys Asn Leu Ile Lys Leu Leu Ile Ile Arg Leu Ile Val Asn Leu 
1               5                   10                  15      

Ala Asp Ser Val Phe Tyr Ile Val Ala Leu Trp His Val Ser Asn Asn 
            20                  25                  30          

Tyr Ser Ser Ser Met Phe Leu Gly Ile Phe Ile Ala Val Asn Tyr Leu 
        35                  40                  45              

Pro Asp Leu Leu Leu Ile Phe Phe Gly Pro Val Ile Asp Arg Val Asn 
    50                  55                  60                  

Pro Gln Lys Ile Leu Ile Ile Ser Ile Leu Val Gln Leu Ala Val Ala 
65                  70                  75                  80  

Val Ile Phe Leu Leu Leu Leu Asn Gln Ile Ser Phe Trp Val Ile Met 
                85                  90                  95      

Ser Leu Val Phe Ile Ser Val Met Ala Ser Ser Ile Ser Tyr Val Ile 
            100                 105                 110         

Glu Asp Val Leu Ile Pro Gln Val Val Glu Tyr Asp Lys Ile Val Phe 
        115                 120                 125             

Ala Asn Ser Leu Phe Ser Ile Ser Tyr Lys Val Leu Asp Ser Ile Phe 
    130                 135                 140                 

Asn Ser Phe Ala Ser Phe Leu Gln Val Ala Val Gly Phe Ile Leu Leu 
145                 150                 155                 160 

Val Lys Ile Asp Ile Gly Ile Phe Leu Leu Ala Leu Phe Ile Leu Leu 
                165                 170                 175     

Leu Leu Lys Phe Arg Thr Ser Asn Ala Asn Ile Glu Asn Phe Ser Phe 
            180                 185                 190         

Lys Tyr Tyr Lys Arg Glu Val Leu Gln Gly Thr Lys Phe Ile Leu Asn 
        195                 200                 205             

Asn Lys Leu Leu Phe Lys Thr Ser Ile Ser Leu Thr Leu Ile Asn Phe 
    210                 215                 220                 

Phe Tyr Ser Phe Gln Thr Val Val Val Pro Ile Phe Ser Ile Arg Tyr 
225                 230                 235                 240 

Phe Asp Gly Pro Ile Phe Tyr Gly Ile Phe Leu Thr Ile Ala Gly Leu 
                245                 250                 255     

Gly Gly Ile Leu Gly Asn Met Leu Ala Pro Ile Val Ile Lys Tyr Leu 
            260                 265                 270         

Lys Ser Asn Gln Ile Val Gly Val Phe Leu Phe Leu Asn Gly Ser Ser 
        275                 280                 285             

Trp Leu Val Ala Ile Val Ile Lys Asp Tyr Thr Leu Ser Leu Ile Leu 
    290                 295                 300                 

Phe Phe Val Cys Phe Met Ser Lys Gly Val Phe Asn Ile Ile Phe Asn 
305                 310                 315                 320 

Ser Leu Tyr Gln Gln Ile Pro Pro His Gln Leu Leu Gly Arg Val Asn 
                325                 330                 335     

Thr Thr Ile Asp Ser Ile Ile Ser Phe Gly Met Pro Ile Gly Ser Leu 
            340                 345                 350         


Val Ala Gly Thr Leu Ile Asp Leu Asn Ile Glu Leu Val Leu Ile Ala 
        355                 360                 365             

Ile Ser Ile Pro Tyr Phe Leu Phe Ser Tyr Ile Phe Tyr Thr Asp Asn 
    370                 375                 380                 

Gly Leu Lys Glu Phe Ser Ile Tyr 
385                 390         

<210>   145
<211>   135
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   145
gtggatggac gtgtaataac ctcttctttc gaggagtatt ttactaaaaa actagccttg   60
gagcgttccc cagaaacgga cttactcatt gactcttcaa agatttgggg agaagatttt   120
gcttcatctg ttcct                                                    135

<210>   146
<211>   45
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lactose phosphotransferase system repressor, degenerate FRAMESHIFT
<223>   Cellular location: cytoplasm

<400>   146
Met Asp Gly Arg Val Ile Thr Ser Ser Phe Glu Glu Tyr Phe Thr Lys 
1               5                   10                  15      

Lys Leu Ala Leu Glu Arg Ser Pro Glu Thr Asp Leu Leu Ile Asp Ser 
            20                  25                  30          

Ser Lys Ile Trp Gly Glu Asp Phe Ala Ser Ser Val Pro 
        35                  40                  45  

<210>   147
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   147
ttggggagaa gattttgctt catctgttcc ttgaaaaaag tcacagcagt catcacagac   60
gatagtactg aacaaaacta tgaagagtta gaaatttata cgcaggtgat tgta         114

<210>   148
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   148
Met Gly Arg Arg Phe Cys Phe Ile Cys Ser Leu Lys Lys Val Thr Ala 
1               5                   10                  15      

Val Ile Thr Asp Asp Ser Thr Glu Gln Asn Tyr Glu Glu Leu Glu Ile 
            20                  25                  30          

Tyr Thr Gln Val Ile Val 
        35              

<210>   149
<211>   231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   149
ttgattagta ttgacctagg tggtacaaat attaagatta ctgttctttc aaatgacggt   60
gagattgaaa ctttgtggag tattacaaca gatacaagtg agaaaggttc tcaaattata   120
tcggacatca tcagttctat taaaaataaa ttgaccgaac ggaatattcc tgatagcgac   180
cttcttggaa tcggtatggg aagttgctca tcatactttc cttgtaaatc a            231

<210>   150
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ROK family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902628 (1.E-13)

<400>   150
Met Ile Ser Ile Asp Leu Gly Gly Thr Asn Ile Lys Ile Thr Val Leu 
1               5                   10                  15      

Ser Asn Asp Gly Glu Ile Glu Thr Leu Trp Ser Ile Thr Thr Asp Thr 
            20                  25                  30          

Ser Glu Lys Gly Ser Gln Ile Ile Ser Asp Ile Ile Ser Ser Ile Lys 
        35                  40                  45              

Asn Lys Leu Thr Glu Arg Asn Ile Pro Asp Ser Asp Leu Leu Gly Ile 
    50                  55                  60                  

Gly Met Gly Ser Cys Ser Ser Tyr Phe Pro Cys Lys Ser 
65                  70                  75          

<210>   151
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   151
ttgattttta ttgagtatac cactatttta ctccctctgg caagggactt tgtctatgtg   60
gagggattgg gctcctatgt ggtggagctt ttctgttctt tc                      102

<210>   152
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   152
Met Ile Phe Ile Glu Tyr Thr Thr Ile Leu Leu Pro Leu Ala Arg Asp 
1               5                   10                  15      

Phe Val Tyr Val Glu Gly Leu Gly Ser Tyr Val Val Glu Leu Phe Cys 
            20                  25                  30          

Ser Phe 
        

<210>   153
<211>   132
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   153
ttgagtatac cactatttta ctccctctgg caagggactt tgtctatgtg gagggattgg   60
gctcctatgt ggtggagctt ttctgttctt tctgaaatat ggtataatag cactaatcaa   120
tttctaggaa aa                                                       132

<210>   154
<211>   44
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   154
Met Ser Ile Pro Leu Phe Tyr Ser Leu Trp Gln Gly Thr Leu Ser Met 
1               5                   10                  15      

Trp Arg Asp Trp Ala Pro Met Trp Trp Ser Phe Ser Val Leu Ser Glu 
            20                  25                  30          

Ile Trp Tyr Asn Ser Thr Asn Gln Phe Leu Gly Lys 
        35                  40                  

<210>   155
<211>   1947
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   155
atgtctcata ttattgaatt gccagagatg ctggcaaacc aaatcgcggc tggagaggtc   60
attgaacgtc ctgccagtgt ggtcaaagag ttggtagaaa atgccattga cgcgggctct   120
agtcagatta tcattgagat tgaggaagct ggtctcaaga aggttcaaat cacggataac   180
ggtcatggaa ttgcccacga tgaggtggag ttggccctgc gtcgccatgc gaccagtaag   240
ataaaaaatc aagcagatct ctttcggatt cggacgcttg gttttcgtgg tgaagccttg   300
ccttctattg cgtctgttag tgtcttgact ctgttaacgg cggtggatgg tgctagtcat   360
ggaaccaagt tagtcgcgcg tgggggtgaa gttgaggaag tcatcccagc gactagtcct   420
gtgggaacca aggtttgtgt ggaggatctc tttttcaaca cgcctgcccg tctcaagtat   480
atgaagagcc agcaagcgga gttgtctcat atcattgata ttgtcaaccg tctgggcttg   540
gcccatcctg agatttcttt tagcttgatt agtgatggca aggaaatgac gcggacagca   600
gggactggtc aattgcgcca agcaatcgca gggatttacg gtttggtcag tgccaagaag   660
atgattgaaa ttgagaactc tgacctagat ttcgaaattt caggttttgt gtccttgcct   720
gagttgactc gggctaaccg caattatatc agcctcttca tcaatggccg ttatattaag   780
aacttcctgc tcaatcgtgc tattttggat ggttttggaa gcaagcttat ggttggacgt   840
tttccactgg ctgtcattca catccatatc gacccttatc tagcggatgt caatgtgcat   900
ccaactaagc aagaggtgcg gatttccaag gaaaaagaac tgatgactct ggtttcagaa   960
gctattgcaa atagtctcaa ggaacaaacc ttgattccag atgccttgga aaatcttgcc   1020
aaatcgaccg tgcgcaatcg tgagaaggtg gagcaaacta ttctcccact caaagaaaat   1080
acgctctact atgagaaaac tgagccgtca agacctagtc aaactgaagt agctgattat   1140
caggtagaat tgactgatga agggcaggat ttgaccctgt ttgccaagga aaccttggac   1200
cgattgacca agccagcaaa actgcatttt gcagagagaa agcctgctaa ctacgaccag   1260
ctagaccatc cagagttaga tcttgctagc atcgataagg cttatgacaa actggagcga   1320
gaagaagcat ccagcttccc agagttggag tttttcggac aaatgcacgg gacttatctc   1380
tttgcccaag ggcgagatgg actttacatc atagatcagc acgctgctca ggaacgggtc   1440
aagtacgagg agtaccgtga aagcattggc aatgttgacc aaagccagca gcaactccta   1500
gtgccctata tctttgaatt tcctgcggat gatgccctgc gtctcaagga aagaatgcct   1560
ctcttagagg aagtgggcgt ctttctagca gagtacggag aaaatcaatt tattctacgt   1620
gaacatccta tttggatggc agaagaagag attgaatcag gcatctatga gatgtgcgac   1680
atgctccttt tgaccaagga agtttctatc aagaaatacc gagcagagct ggctatcatg   1740
atgtcttgca agcgatctat caaggccaat catcgtattg atgatcattc agctagacaa   1800
ctcctctatc agctttctca atgtgacaat ccctataact gtcctcacgg acgtcctgtt   1860
ttggtgcatt ttaccaagtc ggatatggaa aagatgttcc gacgtattca ggaaaatcac   1920
accagtctcc gtgagttggg gaaatat                                       1947

<210>   156
<211>   649
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA mismatch repair protein HexB (hexB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902204 (0.E+01)

<400>   156
Met Ser His Ile Ile Glu Leu Pro Glu Met Leu Ala Asn Gln Ile Ala 
1               5                   10                  15      

Ala Gly Glu Val Ile Glu Arg Pro Ala Ser Val Val Lys Glu Leu Val 
            20                  25                  30          

Glu Asn Ala Ile Asp Ala Gly Ser Ser Gln Ile Ile Ile Glu Ile Glu 
        35                  40                  45              

Glu Ala Gly Leu Lys Lys Val Gln Ile Thr Asp Asn Gly His Gly Ile 
    50                  55                  60                  

Ala His Asp Glu Val Glu Leu Ala Leu Arg Arg His Ala Thr Ser Lys 
65                  70                  75                  80  

Ile Lys Asn Gln Ala Asp Leu Phe Arg Ile Arg Thr Leu Gly Phe Arg 
                85                  90                  95      

Gly Glu Ala Leu Pro Ser Ile Ala Ser Val Ser Val Leu Thr Leu Leu 
            100                 105                 110         

Thr Ala Val Asp Gly Ala Ser His Gly Thr Lys Leu Val Ala Arg Gly 
        115                 120                 125             

Gly Glu Val Glu Glu Val Ile Pro Ala Thr Ser Pro Val Gly Thr Lys 
    130                 135                 140                 

Val Cys Val Glu Asp Leu Phe Phe Asn Thr Pro Ala Arg Leu Lys Tyr 
145                 150                 155                 160 

Met Lys Ser Gln Gln Ala Glu Leu Ser His Ile Ile Asp Ile Val Asn 
                165                 170                 175     

Arg Leu Gly Leu Ala His Pro Glu Ile Ser Phe Ser Leu Ile Ser Asp 
            180                 185                 190         

Gly Lys Glu Met Thr Arg Thr Ala Gly Thr Gly Gln Leu Arg Gln Ala 
        195                 200                 205             

Ile Ala Gly Ile Tyr Gly Leu Val Ser Ala Lys Lys Met Ile Glu Ile 
    210                 215                 220                 

Glu Asn Ser Asp Leu Asp Phe Glu Ile Ser Gly Phe Val Ser Leu Pro 
225                 230                 235                 240 

Glu Leu Thr Arg Ala Asn Arg Asn Tyr Ile Ser Leu Phe Ile Asn Gly 
                245                 250                 255     

Arg Tyr Ile Lys Asn Phe Leu Leu Asn Arg Ala Ile Leu Asp Gly Phe 
            260                 265                 270         

Gly Ser Lys Leu Met Val Gly Arg Phe Pro Leu Ala Val Ile His Ile 
        275                 280                 285             

His Ile Asp Pro Tyr Leu Ala Asp Val Asn Val His Pro Thr Lys Gln 
    290                 295                 300                 

Glu Val Arg Ile Ser Lys Glu Lys Glu Leu Met Thr Leu Val Ser Glu 
305                 310                 315                 320 

Ala Ile Ala Asn Ser Leu Lys Glu Gln Thr Leu Ile Pro Asp Ala Leu 
                325                 330                 335     

Glu Asn Leu Ala Lys Ser Thr Val Arg Asn Arg Glu Lys Val Glu Gln 
            340                 345                 350         

Thr Ile Leu Pro Leu Lys Glu Asn Thr Leu Tyr Tyr Glu Lys Thr Glu 
        355                 360                 365             

Pro Ser Arg Pro Ser Gln Thr Glu Val Ala Asp Tyr Gln Val Glu Leu 
    370                 375                 380                 

Thr Asp Glu Gly Gln Asp Leu Thr Leu Phe Ala Lys Glu Thr Leu Asp 
385                 390                 395                 400 

Arg Leu Thr Lys Pro Ala Lys Leu His Phe Ala Glu Arg Lys Pro Ala 
                405                 410                 415     

Asn Tyr Asp Gln Leu Asp His Pro Glu Leu Asp Leu Ala Ser Ile Asp 
            420                 425                 430         

Lys Ala Tyr Asp Lys Leu Glu Arg Glu Glu Ala Ser Ser Phe Pro Glu 
        435                 440                 445             

Leu Glu Phe Phe Gly Gln Met His Gly Thr Tyr Leu Phe Ala Gln Gly 
    450                 455                 460                 

Arg Asp Gly Leu Tyr Ile Ile Asp Gln His Ala Ala Gln Glu Arg Val 
465                 470                 475                 480 

Lys Tyr Glu Glu Tyr Arg Glu Ser Ile Gly Asn Val Asp Gln Ser Gln 
                485                 490                 495     

Gln Gln Leu Leu Val Pro Tyr Ile Phe Glu Phe Pro Ala Asp Asp Ala 
            500                 505                 510         

Leu Arg Leu Lys Glu Arg Met Pro Leu Leu Glu Glu Val Gly Val Phe 
        515                 520                 525             

Leu Ala Glu Tyr Gly Glu Asn Gln Phe Ile Leu Arg Glu His Pro Ile 
    530                 535                 540                 

Trp Met Ala Glu Glu Glu Ile Glu Ser Gly Ile Tyr Glu Met Cys Asp 
545                 550                 555                 560 

Met Leu Leu Leu Thr Lys Glu Val Ser Ile Lys Lys Tyr Arg Ala Glu 
                565                 570                 575     

Leu Ala Ile Met Met Ser Cys Lys Arg Ser Ile Lys Ala Asn His Arg 
            580                 585                 590         

Ile Asp Asp His Ser Ala Arg Gln Leu Leu Tyr Gln Leu Ser Gln Cys 
        595                 600                 605             

Asp Asn Pro Tyr Asn Cys Pro His Gly Arg Pro Val Leu Val His Phe 
    610                 615                 620                 

Thr Lys Ser Asp Met Glu Lys Met Phe Arg Arg Ile Gln Glu Asn His 
625                 630                 635                 640 

Thr Ser Leu Arg Glu Leu Gly Lys Tyr 
                645                 

<210>   157
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   157
gtggtaaaac acaacttcga tgttacagac aaaactggca aaattagctc aaaacactgt   60
tttgagatta ctgataaaac tgacgtcgtt                                    90

<210>   158
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (N-ethylammeline)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903257 (1.E-07)

<400>   158
Met Val Lys His Asn Phe Asp Val Thr Asp Lys Thr Gly Lys Ile Ser 
1               5                   10                  15      

Ser Lys His Cys Phe Glu Ile Thr Asp Lys Thr Asp Val Val 
            20                  25                  30  

<210>   159
<211>   465
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   159
atgaacactt atgaaggtaa tttagtagca aacaatatta aaataggtat tgttgtagcg   60
agatttaatg aatttataac ttcaaaatta ttatctggag cactagataa tctcaaaaga   120
gagaatgtaa acgagaaaga tatagaggta gcctgggttc caggagcttt tgaaatacca   180
ctgattgcat caaaaatggc aaaaagtaaa aaatatgatg caattatctg cttgggagct   240
gtcattagag ggaatacaag tcattatgat tatgtatgta gcgaggtatc taagggaatc   300
gcccaaatca gtttaaatag cgaaattcct gttatgtttg gtgtgctaac gacagataca   360
attgaacaag ccatagaacg agctggtact aaagcaggaa ataagggttc tgagtgtgca   420
caaggagcta ttgaaatggt caacctgatt cgtacattag acgca                   465

<210>   160
<211>   155
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   riboflavin synthase, beta subunit (ribH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902205 (1.E-84)

<400>   160
Met Asn Thr Tyr Glu Gly Asn Leu Val Ala Asn Asn Ile Lys Ile Gly 
1               5                   10                  15      

Ile Val Val Ala Arg Phe Asn Glu Phe Ile Thr Ser Lys Leu Leu Ser 
            20                  25                  30          

Gly Ala Leu Asp Asn Leu Lys Arg Glu Asn Val Asn Glu Lys Asp Ile 
        35                  40                  45              

Glu Val Ala Trp Val Pro Gly Ala Phe Glu Ile Pro Leu Ile Ala Ser 
    50                  55                  60                  

Lys Met Ala Lys Ser Lys Lys Tyr Asp Ala Ile Ile Cys Leu Gly Ala 
65                  70                  75                  80  

Val Ile Arg Gly Asn Thr Ser His Tyr Asp Tyr Val Cys Ser Glu Val 
                85                  90                  95      

Ser Lys Gly Ile Ala Gln Ile Ser Leu Asn Ser Glu Ile Pro Val Met 
            100                 105                 110         

Phe Gly Val Leu Thr Thr Asp Thr Ile Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             

Gly Thr Lys Ala Gly Asn Lys Gly Ser Glu Cys Ala Gln Gly Ala Ile 
    130                 135                 140                 

Glu Met Val Asn Leu Ile Arg Thr Leu Asp Ala 
145                 150                 155 

<210>   161
<211>   1233
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   161
atggatttta gcagaaagga taatcagtca atggaatatc gaaaaataca agaagcatta   60
gaagcattgc agaagggacg acttgttctt gttatagacg acaaggatag agaaaatgaa   120
ggagacttaa tttgttctgc acaagcagct acaacagaaa atgttaattt tatggctact   180
tatgccaaag gattaatttg tatgcctatg agcgaaagtt tagctaatca attaatgctt   240
tcacctatgg ttgaaaacaa tacagataat cataagactg cttttacagt ttcaattgat   300
tataaagaaa cgaccacagg tatttctgcc gaggaaagag gactgaccgc acgtatgtgt   360
gtagctgaag atataacacc ctctgatttt cgcaggccag gacacatgtt tcctttaatt   420
gcaaaaaaag gtggtgtcct agaaagaaat ggacacacag aagcaactgt tgatttatta   480
aaattagctg gactaaaaga gtgtggccta tgttgtgaaa taatgaatca tgatggcaaa   540
atgatgagaa cagatgattt aattcagttc tcgaaaaaac acaacattcc actaattacc   600
atcaaagaat tacaagaata tagaaaagta tatgatcagc tggtagaacg agtttcaact   660
gtcaatatgc ctactagata cggtaatttc aaagcaatta gctatataga taaactaaat   720
ggggaacatc atcttgctct tattatggga aatatagagg atgaagccaa tgtattatgt   780
cgggtccact ccgaatgttt aacaggagat gttttaggct ctttacgttg cgattgtgga   840
cagcaattcg ataaggctat gaaaatgatt gttgagaatg gttcgggtgt cttactttac   900
ttgcgacagg agggacgagg aattggactt atcaataaat taaaagccta tcatttacaa   960
gatcaaggca tggatacgct tgatgccaat cttgcattag gctttgaagg tgatttaaga   1020
gaatatcata ttggagcaaa aatgcttaaa gatctgggac ttcagtcact tcatttactg   1080
acaaataatc ctgacaaggt tgaacagtta gaaaaatatg gaattaccat ttccagtaga   1140
atatcaatcg aaatagaagc caatccttac gatagttttt atttagaaac aaagaaaaat   1200
cgaatgggtc acattttaaa tatggaggaa aaa                                1233

<210>   162
<211>   411
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II (ri
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902206 (0.E+01)

<400>   162
Met Asp Phe Ser Arg Lys Asp Asn Gln Ser Met Glu Tyr Arg Lys Ile 
1               5                   10                  15      

Gln Glu Ala Leu Glu Ala Leu Gln Lys Gly Arg Leu Val Leu Val Ile 
            20                  25                  30          

Asp Asp Lys Asp Arg Glu Asn Glu Gly Asp Leu Ile Cys Ser Ala Gln 
        35                  40                  45              

Ala Ala Thr Thr Glu Asn Val Asn Phe Met Ala Thr Tyr Ala Lys Gly 
    50                  55                  60                  

Leu Ile Cys Met Pro Met Ser Glu Ser Leu Ala Asn Gln Leu Met Leu 
65                  70                  75                  80  

Ser Pro Met Val Glu Asn Asn Thr Asp Asn His Lys Thr Ala Phe Thr 
                85                  90                  95      

Val Ser Ile Asp Tyr Lys Glu Thr Thr Thr Gly Ile Ser Ala Glu Glu 
            100                 105                 110         

Arg Gly Leu Thr Ala Arg Met Cys Val Ala Glu Asp Ile Thr Pro Ser 
        115                 120                 125             

Asp Phe Arg Arg Pro Gly His Met Phe Pro Leu Ile Ala Lys Lys Gly 
    130                 135                 140                 

Gly Val Leu Glu Arg Asn Gly His Thr Glu Ala Thr Val Asp Leu Leu 
145                 150                 155                 160 

Lys Leu Ala Gly Leu Lys Glu Cys Gly Leu Cys Cys Glu Ile Met Asn 
                165                 170                 175     

His Asp Gly Lys Met Met Arg Thr Asp Asp Leu Ile Gln Phe Ser Lys 
            180                 185                 190         

Lys His Asn Ile Pro Leu Ile Thr Ile Lys Glu Leu Gln Glu Tyr Arg 
        195                 200                 205             

Lys Val Tyr Asp Gln Leu Val Glu Arg Val Ser Thr Val Asn Met Pro 
    210                 215                 220                 

Thr Arg Tyr Gly Asn Phe Lys Ala Ile Ser Tyr Ile Asp Lys Leu Asn 
225                 230                 235                 240 

Gly Glu His His Leu Ala Leu Ile Met Gly Asn Ile Glu Asp Glu Ala 

                245                 250                 255     

Asn Val Leu Cys Arg Val His Ser Glu Cys Leu Thr Gly Asp Val Leu 
            260                 265                 270         

Gly Ser Leu Arg Cys Asp Cys Gly Gln Gln Phe Asp Lys Ala Met Lys 
        275                 280                 285             

Met Ile Val Glu Asn Gly Ser Gly Val Leu Leu Tyr Leu Arg Gln Glu 
    290                 295                 300                 

Gly Arg Gly Ile Gly Leu Ile Asn Lys Leu Lys Ala Tyr His Leu Gln 
305                 310                 315                 320 

Asp Gln Gly Met Asp Thr Leu Asp Ala Asn Leu Ala Leu Gly Phe Glu 
                325                 330                 335     

Gly Asp Leu Arg Glu Tyr His Ile Gly Ala Lys Met Leu Lys Asp Leu 
            340                 345                 350         

Gly Leu Gln Ser Leu His Leu Leu Thr Asn Asn Pro Asp Lys Val Glu 
        355                 360                 365             

Gln Leu Glu Lys Tyr Gly Ile Thr Ile Ser Ser Arg Ile Ser Ile Glu 
    370                 375                 380                 

Ile Glu Ala Asn Pro Tyr Asp Ser Phe Tyr Leu Glu Thr Lys Lys Asn 
385                 390                 395                 400 

Arg Met Gly His Ile Leu Asn Met Glu Glu Lys 
                405                 410     

<210>   163
<211>   633
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   163
atgttcacag gaataattga agaaatcgga aaagttgaaa gaatacagaa agactctcgt   60
aattgtaaac tatcaattaa agcctcaaaa atattaacgg atatccattt aggcgatagt   120
atagcagtaa atggtatctg tcttacagtt actcatttca atcatcaatc ctttacagtt   180
gatgtaatga atgaaacatg gagtcgaaca gctcttactc tattaaaaca tggaagtgag   240
gtgaatctag aaagagcctt atctgtcaac ggtcgacttg ggggtcacgt cgttacagga   300
cacattgatg gtacaggaaa aatctcgtca ataaaaaaag atgataatgc tgtatggtat   360
caaatcaaca cacaaaaaga aattttagat ttaatagttg aaaaaggatc tattacaatt   420
gacggcatta gtctgactgt cgctaaagtc tccaaagtaa acttttcagt atctgttatc   480
cctcatacct tggaacaaac cattcttaag agtaaacaag tcgggagtac agtaaatctt   540
gaaaatgata tcttaggtaa atatgtgcaa aaactgatgg ataactctcc aaaatcagaa   600
atatctaagg aactattata tcaaaatgga ttt                                633

<210>   164
<211>   211
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   riboflavin synthase, alpha subunit (ribE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902207 (e-117)

<400>   164
Met Phe Thr Gly Ile Ile Glu Glu Ile Gly Lys Val Glu Arg Ile Gln 
1               5                   10                  15      

Lys Asp Ser Arg Asn Cys Lys Leu Ser Ile Lys Ala Ser Lys Ile Leu 
            20                  25                  30          

Thr Asp Ile His Leu Gly Asp Ser Ile Ala Val Asn Gly Ile Cys Leu 
        35                  40                  45              

Thr Val Thr His Phe Asn His Gln Ser Phe Thr Val Asp Val Met Asn 
    50                  55                  60                  

Glu Thr Trp Ser Arg Thr Ala Leu Thr Leu Leu Lys His Gly Ser Glu 
65                  70                  75                  80  

Val Asn Leu Glu Arg Ala Leu Ser Val Asn Gly Arg Leu Gly Gly His 
                85                  90                  95      

Val Val Thr Gly His Ile Asp Gly Thr Gly Lys Ile Ser Ser Ile Lys 
            100                 105                 110         

Lys Asp Asp Asn Ala Val Trp Tyr Gln Ile Asn Thr Gln Lys Glu Ile 
        115                 120                 125             

Leu Asp Leu Ile Val Glu Lys Gly Ser Ile Thr Ile Asp Gly Ile Ser 
    130                 135                 140                 

Leu Thr Val Ala Lys Val Ser Lys Val Asn Phe Ser Val Ser Val Ile 
145                 150                 155                 160 

Pro His Thr Leu Glu Gln Thr Ile Leu Lys Ser Lys Gln Val Gly Ser 
                165                 170                 175     

Thr Val Asn Leu Glu Asn Asp Ile Leu Gly Lys Tyr Val Gln Lys Leu 
            180                 185                 190         

Met Asp Asn Ser Pro Lys Ser Glu Ile Ser Lys Glu Leu Leu Tyr Gln 
        195                 200                 205             

Asn Gly Phe 
    210     

<210>   165
<211>   1194
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   165
ttgtcatttc agagcatttt tgttaatcgc ataagttttc ttttgtatgc cttgagtagt   60
cccctattca aggtatattt ttttggaggt agcgagatga gcgattcaaa atatatgaaa   120
ttagcaataa aactggcaca aaaaggggct ggttacgtca atcccaatcc tatggtcggc   180
gcagttattg taaaagataa tcacattatc ggacaaggtt atcatgagtt ttttggtggc   240
ccacatgctg agagaaatgc tcttaaaaac tgtagagaat cccctgtcgg agcgacgctt   300
tatgtaacac ttgaaccctg ttgtcacttc gggaaaacac ctccctgtat agatgctata   360
atcgatagtg gtattacaag agtagtcatt ggaagcctag actgtaatcc tattgtatct   420
ggaaaaggag taaagatact tgaggaaaat aatcttcaag ttactgttgg aattttagaa   480
aatgagtgtc ttaacttaat aaaaagtttt agaaagtata ttacccagca tgtaccctat   540
gtttttatga aatatgcaat gtcaatggat ggaaaaatag ccactaaaac aaatcaatcc   600
aaatggatta ctgaagaaga agcaagaaag catgtgcatc agttacgaca ccatgttagt   660
gcaattatgg tgggagtcaa tactgttatt caagacgatc ctttgctgac atgtagattg   720
gaggaaggga aaaatcctat ccgtatcata tgcgatacac atttacgaac tcctcttacc   780
tctaaaatcg taaaaacagc aaatgatatt aaaacttaca ttgccacttc ctctgaagac   840
aaaaataaaa tgaagctata tcaaaatcat ggctgtgaaa tactttccat aaagaaaaaa   900
ggcaatcata tagacttatc gagtttaatg caacatctag gaaacatgca gattgatagc   960
ctagttctag aagggggcag tctaatgaat tggagtgctt tggaacaaca aattgttgat   1020
gagctgaaaa tatatattgc accaaaagtt tttggaggta gtgccaagtt tcctgtcgga   1080
ggtgaaggta tttctttgcc aaatgacgct attagattga aaccttatgc attttctcaa   1140
ataggaaatg actatctcat agaaagtgaa gtgatttatc catgttcaca ggaa         1194

<210>   166
<211>   398
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   riboflavin biosynthesis protein RibD (ribD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902208 (0.E+01)

<400>   166
Met Ser Phe Gln Ser Ile Phe Val Asn Arg Ile Ser Phe Leu Leu Tyr 
1               5                   10                  15      

Ala Leu Ser Ser Pro Leu Phe Lys Val Tyr Phe Phe Gly Gly Ser Glu 
            20                  25                  30          

Met Ser Asp Ser Lys Tyr Met Lys Leu Ala Ile Lys Leu Ala Gln Lys 
        35                  40                  45              

Gly Ala Gly Tyr Val Asn Pro Asn Pro Met Val Gly Ala Val Ile Val 
    50                  55                  60                  

Lys Asp Asn His Ile Ile Gly Gln Gly Tyr His Glu Phe Phe Gly Gly 
65                  70                  75                  80  

Pro His Ala Glu Arg Asn Ala Leu Lys Asn Cys Arg Glu Ser Pro Val 
                85                  90                  95      

Gly Ala Thr Leu Tyr Val Thr Leu Glu Pro Cys Cys His Phe Gly Lys 
            100                 105                 110         

Thr Pro Pro Cys Ile Asp Ala Ile Ile Asp Ser Gly Ile Thr Arg Val 
        115                 120                 125             

Val Ile Gly Ser Leu Asp Cys Asn Pro Ile Val Ser Gly Lys Gly Val 
    130                 135                 140                 

Lys Ile Leu Glu Glu Asn Asn Leu Gln Val Thr Val Gly Ile Leu Glu 
145                 150                 155                 160 

Asn Glu Cys Leu Asn Leu Ile Lys Ser Phe Arg Lys Tyr Ile Thr Gln 
                165                 170                 175     

His Val Pro Tyr Val Phe Met Lys Tyr Ala Met Ser Met Asp Gly Lys 

            180                 185                 190         

Ile Ala Thr Lys Thr Asn Gln Ser Lys Trp Ile Thr Glu Glu Glu Ala 
        195                 200                 205             

Arg Lys His Val His Gln Leu Arg His His Val Ser Ala Ile Met Val 
    210                 215                 220                 

Gly Val Asn Thr Val Ile Gln Asp Asp Pro Leu Leu Thr Cys Arg Leu 
225                 230                 235                 240 

Glu Glu Gly Lys Asn Pro Ile Arg Ile Ile Cys Asp Thr His Leu Arg 
                245                 250                 255     

Thr Pro Leu Thr Ser Lys Ile Val Lys Thr Ala Asn Asp Ile Lys Thr 
            260                 265                 270         

Tyr Ile Ala Thr Ser Ser Glu Asp Lys Asn Lys Met Lys Leu Tyr Gln 
        275                 280                 285             

Asn His Gly Cys Glu Ile Leu Ser Ile Lys Lys Lys Gly Asn His Ile 
    290                 295                 300                 

Asp Leu Ser Ser Leu Met Gln His Leu Gly Asn Met Gln Ile Asp Ser 
305                 310                 315                 320 

Leu Val Leu Glu Gly Gly Ser Leu Met Asn Trp Ser Ala Leu Glu Gln 
                325                 330                 335     

Gln Ile Val Asp Glu Leu Lys Ile Tyr Ile Ala Pro Lys Val Phe Gly 
            340                 345                 350         

Gly Ser Ala Lys Phe Pro Val Gly Gly Glu Gly Ile Ser Leu Pro Asn 
        355                 360                 365             

Asp Ala Ile Arg Leu Lys Pro Tyr Ala Phe Ser Gln Ile Gly Asn Asp 
    370                 375                 380                 

Tyr Leu Ile Glu Ser Glu Val Ile Tyr Pro Cys Ser Gln Glu 
385                 390                 395             


<210>   167
<211>   591
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   167
atgtacgcat atttaaaagg aatcattacc aaaattactg ccaaatacat tgttcttgaa   60
accaatggta ttggttatat cctgcatgtg gccaatcctt atgcctattc aggtcaggtt   120
aatcaggagg ctcagattta tgtgcatcag gttgtgcgtg aggacgccca tttgctttat   180
ggatttcgct cagaggatga gaaaaagctc tttcttagtc tgatttcggt ctctgggatt   240
ggtcctgtat cagctcttgc tattatcgct gctgatgaca atgctggctt ggttcaagcc   300
attgaaacca agaacatcac ctacttgacc aagttcccta aaattggcaa gaaaacagcc   360
cagcagatgg tgctggactt ggaaggcaag gtagtagttg caggagatga ccttcctgcc   420
aaggtcgcag tgcaagcaag tgctgaaaac caagaattgg aagaagctat ggaagccatg   480
ttggctctgg gctacaaggc aacagagctc aagaaaatca agaaattctt tgaaggaacg   540
acagatacag ctgagaacta tatcaagtcg gcccttaaaa tgttggtcaa a            591

<210>   168
<211>   197
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Holliday junction DNA helicase RuvA (ruvA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902209 (e-106)

<400>   168
Met Tyr Ala Tyr Leu Lys Gly Ile Ile Thr Lys Ile Thr Ala Lys Tyr 
1               5                   10                  15      

Ile Val Leu Glu Thr Asn Gly Ile Gly Tyr Ile Leu His Val Ala Asn 
            20                  25                  30          

Pro Tyr Ala Tyr Ser Gly Gln Val Asn Gln Glu Ala Gln Ile Tyr Val 
        35                  40                  45              

His Gln Val Val Arg Glu Asp Ala His Leu Leu Tyr Gly Phe Arg Ser 
    50                  55                  60                  

Glu Asp Glu Lys Lys Leu Phe Leu Ser Leu Ile Ser Val Ser Gly Ile 
65                  70                  75                  80  

Gly Pro Val Ser Ala Leu Ala Ile Ile Ala Ala Asp Asp Asn Ala Gly 
                85                  90                  95      

Leu Val Gln Ala Ile Glu Thr Lys Asn Ile Thr Tyr Leu Thr Lys Phe 
            100                 105                 110         

Pro Lys Ile Gly Lys Lys Thr Ala Gln Gln Met Val Leu Asp Leu Glu 
        115                 120                 125             

Gly Lys Val Val Val Ala Gly Asp Asp Leu Pro Ala Lys Val Ala Val 
    130                 135                 140                 

Gln Ala Ser Ala Glu Asn Gln Glu Leu Glu Glu Ala Met Glu Ala Met 
145                 150                 155                 160 

Leu Ala Leu Gly Tyr Lys Ala Thr Glu Leu Lys Lys Ile Lys Lys Phe 
                165                 170                 175     

Phe Glu Gly Thr Thr Asp Thr Ala Glu Asn Tyr Ile Lys Ser Ala Leu 
            180                 185                 190         

Lys Met Leu Val Lys 
        195         

<210>   169
<211>   534
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   169
atgaccaacc cgctctacat cgcctatcat gatgaggagt ggggccagcc cctccatgat   60
gaccaagtat tgtttgagtt gttgtgtatg gaaacctatc aggcaggcct gtcttgggaa   120
acggtactca acaaacgcca agctttccga gaagtctttc atagctatca aattcactca   180
gtcgcagaga tgactgacac tgaattggaa gccatgctgg agaatccagc tatcattcga   240
aatagagcca agctttttgc tacacgcgct aacgcccaag cctttctaca gttacaggca   300
gagtacggct cttttgatgc ctatctttgg tcttttgttg aggggaaaac tgtcgttaac   360
gatgttcctg attatcgcca agcgccagct aaaacaccct tatctgagaa attagccaaa   420
gatctcaaaa aacgaggctt caagttcaca ggcccagtcg ccgtattgtc ttttctacag   480
gctgcagggc tagttgatga ccacgagaat gattgtgagt ggaaaggtct taaa         534

<210>   170
<211>   178
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-3-methyladenine glycosylase I (tag)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902210 (e-102)

<400>   170
Met Thr Asn Pro Leu Tyr Ile Ala Tyr His Asp Glu Glu Trp Gly Gln 
1               5                   10                  15      

Pro Leu His Asp Asp Gln Val Leu Phe Glu Leu Leu Cys Met Glu Thr 
            20                  25                  30          

Tyr Gln Ala Gly Leu Ser Trp Glu Thr Val Leu Asn Lys Arg Gln Ala 
        35                  40                  45              

Phe Arg Glu Val Phe His Ser Tyr Gln Ile His Ser Val Ala Glu Met 
    50                  55                  60                  

Thr Asp Thr Glu Leu Glu Ala Met Leu Glu Asn Pro Ala Ile Ile Arg 
65                  70                  75                  80  

Asn Arg Ala Lys Leu Phe Ala Thr Arg Ala Asn Ala Gln Ala Phe Leu 
                85                  90                  95      

Gln Leu Gln Ala Glu Tyr Gly Ser Phe Asp Ala Tyr Leu Trp Ser Phe 
            100                 105                 110         

Val Glu Gly Lys Thr Val Val Asn Asp Val Pro Asp Tyr Arg Gln Ala 
        115                 120                 125             

Pro Ala Lys Thr Pro Leu Ser Glu Lys Leu Ala Lys Asp Leu Lys Lys 
    130                 135                 140                 

Arg Gly Phe Lys Phe Thr Gly Pro Val Ala Val Leu Ser Phe Leu Gln 
145                 150                 155                 160 

Ala Ala Gly Leu Val Asp Asp His Glu Asn Asp Cys Glu Trp Lys Gly 
                165                 170                 175     

Leu Lys 
        

<210>   171
<211>   675
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   171
atgatgtcta acaaaaataa ggaaattctg atttttgcga ttctctatac agtcctcttt   60
atgtttgatg gcgttaaatt gctggcttct ttaatgccat ctgccattgc aaattatctt   120
gtttatgtag ttttagctct atatggctcc ttcttgttca aggatagatt gatccaacaa   180
tggaaggaga ttagaaagac taaaagaaaa ttcttctttg gagtcttaac aggatggctc   240
tttctcattc tgatgactgt tgtctttgaa tttgtatcag agatgttgaa gcagtttgtg   300
ggactagatg gacaaggtct aaatcagtct aatattcaaa gtacctttca agaacaacca   360
ctactgatag ctgtttttgc ttgtgtcatt ggacctctgg tagaagaatt atttttccgt   420
caggtcttat tgcattactt gcaggaacgg ttgtcaggtt tactaagcat tattctggta   480
ggacttgttt ttgctctgac tcatatgcac agtttggctc tatcagagtg gattggtgca   540
gttggttact taggtggagg ccttgccttt tctattattt atgtgaaaga aaaagagaat   600
atctactatc ccctacttgt tcacatgtta agcaacagcc tctccttaat cattttagct   660
atcagtatag taaaa                                                    675

<210>   172
<211>   225
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902211 (e-122)

<400>   172
Met Met Ser Asn Lys Asn Lys Glu Ile Leu Ile Phe Ala Ile Leu Tyr 
1               5                   10                  15      

Thr Val Leu Phe Met Phe Asp Gly Val Lys Leu Leu Ala Ser Leu Met 
            20                  25                  30          

Pro Ser Ala Ile Ala Asn Tyr Leu Val Tyr Val Val Leu Ala Leu Tyr 
        35                  40                  45              

Gly Ser Phe Leu Phe Lys Asp Arg Leu Ile Gln Gln Trp Lys Glu Ile 
    50                  55                  60                  

Arg Lys Thr Lys Arg Lys Phe Phe Phe Gly Val Leu Thr Gly Trp Leu 
65                  70                  75                  80  

Phe Leu Ile Leu Met Thr Val Val Phe Glu Phe Val Ser Glu Met Leu 
                85                  90                  95      

Lys Gln Phe Val Gly Leu Asp Gly Gln Gly Leu Asn Gln Ser Asn Ile 
            100                 105                 110         

Gln Ser Thr Phe Gln Glu Gln Pro Leu Leu Ile Ala Val Phe Ala Cys 
        115                 120                 125             

Val Ile Gly Pro Leu Val Glu Glu Leu Phe Phe Arg Gln Val Leu Leu 
    130                 135                 140                 

His Tyr Leu Gln Glu Arg Leu Ser Gly Leu Leu Ser Ile Ile Leu Val 
145                 150                 155                 160 

Gly Leu Val Phe Ala Leu Thr His Met His Ser Leu Ala Leu Ser Glu 
                165                 170                 175     

Trp Ile Gly Ala Val Gly Tyr Leu Gly Gly Gly Leu Ala Phe Ser Ile 
            180                 185                 190         

Ile Tyr Val Lys Glu Lys Glu Asn Ile Tyr Tyr Pro Leu Leu Val His 
        195                 200                 205             

Met Leu Ser Asn Ser Leu Ser Leu Ile Ile Leu Ala Ile Ser Ile Val 
    210                 215                 220                 

Lys 
225 

<210>   173
<211>   1029
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   173
atggtttcta ctattggtat tgttagttta tctagtggca ttatcggaga ggattttgtc   60
aaacacgaag tggacttggg tatccaacgt ctcaaggatc tgggactcaa tcccatcttt   120
ttgccccatt cgttaaaagg attagacttt atcaaggacc atcctgaagc tcgtgcagag   180
gatttgattc atgccttttc tgatgatagc atcgacatga tcctatgtgc catcggtgga   240
gacgatacct atcgcttgct accttatctt tttgaaaatg accaactcca aaaggttatc   300
aagcaaaaaa tttttcttgg cttctcggat acaaccatga accacctcat gttgcataaa   360
ttaggaatca agacttttta tggtcaatcc tttttagcag acatttgtga attagacaaa   420
gaaatgctag cctatagcct tcactacttt aaagaattga ttgagacggg aagaatttca   480
gaaatccgcc ctagtgacgt ttggtatgag gaacgaactg attttagtcc cacggccctg   540
ggaacacctc gtgtcagtca tacaaataca ggttttgact tgttgcaagg aagtgcccag   600
ttcgagggga aaatcctcgg tggttgcctc gaatccctct acgatatctt tgacaactct   660
cgatacgcag atagcacgga actctgccaa aaatacaaac ttttccctga cttgtcagac   720
tgggaaggga aaatcctctt gctcgaaaca agcgaagaaa agcctaagcc agaagacttc   780
aaaaagatgt tgctaacttt aaaggacact ggcatattcg cggtcatcaa tggactcttg   840
gtcggaaaac ctatggatga aactttccat gacgactata aagaggcact attggatatc   900
attgacagca atatcccgat tgtctataat ctgaatgtcg gccacgcaac tccaagagca   960
attgtaccct ttggggtcca tgctcatgta gatgcacagg aacaagtcat tctctttgac   1020
tataacaaa                                                           1029

<210>   174
<211>   343
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MccC family protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902212 (0.E+01)

<400>   174
Met Val Ser Thr Ile Gly Ile Val Ser Leu Ser Ser Gly Ile Ile Gly 
1               5                   10                  15      

Glu Asp Phe Val Lys His Glu Val Asp Leu Gly Ile Gln Arg Leu Lys 
            20                  25                  30          

Asp Leu Gly Leu Asn Pro Ile Phe Leu Pro His Ser Leu Lys Gly Leu 
        35                  40                  45              

Asp Phe Ile Lys Asp His Pro Glu Ala Arg Ala Glu Asp Leu Ile His 
    50                  55                  60                  

Ala Phe Ser Asp Asp Ser Ile Asp Met Ile Leu Cys Ala Ile Gly Gly 
65                  70                  75                  80  

Asp Asp Thr Tyr Arg Leu Leu Pro Tyr Leu Phe Glu Asn Asp Gln Leu 
                85                  90                  95      

Gln Lys Val Ile Lys Gln Lys Ile Phe Leu Gly Phe Ser Asp Thr Thr 
            100                 105                 110         

Met Asn His Leu Met Leu His Lys Leu Gly Ile Lys Thr Phe Tyr Gly 
        115                 120                 125             

Gln Ser Phe Leu Ala Asp Ile Cys Glu Leu Asp Lys Glu Met Leu Ala 
    130                 135                 140                 

Tyr Ser Leu His Tyr Phe Lys Glu Leu Ile Glu Thr Gly Arg Ile Ser 
145                 150                 155                 160 

Glu Ile Arg Pro Ser Asp Val Trp Tyr Glu Glu Arg Thr Asp Phe Ser 
                165                 170                 175     


Pro Thr Ala Leu Gly Thr Pro Arg Val Ser His Thr Asn Thr Gly Phe 
            180                 185                 190         

Asp Leu Leu Gln Gly Ser Ala Gln Phe Glu Gly Lys Ile Leu Gly Gly 
        195                 200                 205             

Cys Leu Glu Ser Leu Tyr Asp Ile Phe Asp Asn Ser Arg Tyr Ala Asp 
    210                 215                 220                 

Ser Thr Glu Leu Cys Gln Lys Tyr Lys Leu Phe Pro Asp Leu Ser Asp 
225                 230                 235                 240 

Trp Glu Gly Lys Ile Leu Leu Leu Glu Thr Ser Glu Glu Lys Pro Lys 
                245                 250                 255     

Pro Glu Asp Phe Lys Lys Met Leu Leu Thr Leu Lys Asp Thr Gly Ile 
            260                 265                 270         

Phe Ala Val Ile Asn Gly Leu Leu Val Gly Lys Pro Met Asp Glu Thr 
        275                 280                 285             

Phe His Asp Asp Tyr Lys Glu Ala Leu Leu Asp Ile Ile Asp Ser Asn 
    290                 295                 300                 

Ile Pro Ile Val Tyr Asn Leu Asn Val Gly His Ala Thr Pro Arg Ala 
305                 310                 315                 320 

Ile Val Pro Phe Gly Val His Ala His Val Asp Ala Gln Glu Gln Val 
                325                 330                 335     

Ile Leu Phe Asp Tyr Asn Lys 
            340             

<210>   175
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   175
gtgcaggacc aacacgctat caagaataag aaaacgataa aagcaactgc aggtgcggtt   60
gctttttcac ttactttttt gagttatatt caa                                93

<210>   176
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   176
Met Gln Asp Gln His Ala Ile Lys Asn Lys Lys Thr Ile Lys Ala Thr 
1               5                   10                  15      

Ala Gly Ala Val Ala Phe Ser Leu Thr Phe Leu Ser Tyr Ile Gln 
            20                  25                  30      

<210>   177
<211>   702
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   177
atggttctaa gaggagttcc tatgtctcaa attgatctac aaaaattaac taagaaaaac   60
caagagtttg tccacattgc tacccaacaa ttcatcaaag atgggaaaac agacgctgaa   120
atccagacta tttttgagga agtcattccc caaatccttg aggagcaatc taaaggtaca   180
actgcccgtt ccctatacgg cgcaccaact cattgggctc atagcttcac tgtcaaagag   240
cagtacgaaa aagagcatcc aaaagaaaat gatgacccaa aactgatgat tatggactca   300
gctcttttca tcactagcct ctttgccctt gtcagcgccc tcacaacctt ctttgcggca   360
gaccaagctt tcggctatgg attgattact cttctattag ttggactggt tggtggattt   420
gccttctact tgatgtacta ctttgtttac caatactatg gaccagatat ggatcgcagt   480
caacgtccac ctttctggaa atctgtacta gttatcctag cttctatgtt cctttggttg   540
cttgtcttct ttgcaacaag cttcctacca gctagcctta acccagtact ggatccattg   600
ccactagcta ttattggagc agccctccta gcccttcgct tctatctcaa gaaacgcttg   660
aatatccgta gtgcaagtgc aggaccaaca cgctatcaag aa                      702

<210>   178
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902213 (e-132)

<400>   178
Met Val Leu Arg Gly Val Pro Met Ser Gln Ile Asp Leu Gln Lys Leu 
1               5                   10                  15      

Thr Lys Lys Asn Gln Glu Phe Val His Ile Ala Thr Gln Gln Phe Ile 
            20                  25                  30          

Lys Asp Gly Lys Thr Asp Ala Glu Ile Gln Thr Ile Phe Glu Glu Val 
        35                  40                  45              

Ile Pro Gln Ile Leu Glu Glu Gln Ser Lys Gly Thr Thr Ala Arg Ser 
    50                  55                  60                  

Leu Tyr Gly Ala Pro Thr His Trp Ala His Ser Phe Thr Val Lys Glu 
65                  70                  75                  80  

Gln Tyr Glu Lys Glu His Pro Lys Glu Asn Asp Asp Pro Lys Leu Met 
                85                  90                  95      

Ile Met Asp Ser Ala Leu Phe Ile Thr Ser Leu Phe Ala Leu Val Ser 
            100                 105                 110         

Ala Leu Thr Thr Phe Phe Ala Ala Asp Gln Ala Phe Gly Tyr Gly Leu 
        115                 120                 125             

Ile Thr Leu Leu Leu Val Gly Leu Val Gly Gly Phe Ala Phe Tyr Leu 
    130                 135                 140                 

Met Tyr Tyr Phe Val Tyr Gln Tyr Tyr Gly Pro Asp Met Asp Arg Ser 
145                 150                 155                 160 

Gln Arg Pro Pro Phe Trp Lys Ser Val Leu Val Ile Leu Ala Ser Met 
                165                 170                 175     

Phe Leu Trp Leu Leu Val Phe Phe Ala Thr Ser Phe Leu Pro Ala Ser 
            180                 185                 190         

Leu Asn Pro Val Leu Asp Pro Leu Pro Leu Ala Ile Ile Gly Ala Ala 
        195                 200                 205             

Leu Leu Ala Leu Arg Phe Tyr Leu Lys Lys Arg Leu Asn Ile Arg Ser 
    210                 215                 220                 

Ala Ser Ala Gly Pro Thr Arg Tyr Gln Glu 
225                 230                 

<210>   179
<211>   942
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   179
atgaaacaag tttttctctc tacaacaact gaatttaaag agatcgatac gcttgaaccg   60
ggtacttgga tcaatctcgt caatccgact caaaatgaat cactcgaaat cgccaacacc   120
ttcgatattg atattgctga ccttcgagca ccgctcgatg cggaagaaat gtctcgtatt   180
accattgaag acgagtatac cctgattatc gtagacgtgc cggtcacgga ggaaagaaat   240
aaccgcacct actacgtaac catcccgctt ggtattatca tcactgagga aaccattatc   300
actacgtgtt tggaaccact acctgtcctt gatgtcttta tcaaccgtcg attgcgtaat   360
ttctatacct tcatgcgttc acgttttatc tttcaaattc tttatcgcaa tgcagagctt   420
tacctaacag cccttcgttc aatcgaccgc aagagtgaac aaatcgaaag tcaactgcat   480
caatcaactc gtaatgaaga attgattgag ctcatggaat tggaaaaaac tatcgtctat   540
ttcaaggcct ccctcaaaac aaatgagcgc gtgattaaga aattgaccag ttcaaccagc   600
aatatcaaga aataccttga ggacgaagac ctgcttgaag acaccctgat tgaaacccaa   660
caggccatcg agatggcaga tatttatgga aacgtcttgc attctatgac agagaccttt   720
gcctctatca tttctaacaa ccagaacaac atcatgaaaa ccttggccct tgtgaccatc   780
gtcatgtcca tcccaaccat ggtcttttct gcctacggga tgaactttaa ggataatgaa   840
atccccctaa acggagagcc aaatgccttc tggttaatcg tctttatcgc ctttgctatg   900
agtgtctcgc tcactctcta tctcatccat aaaaaatggt tc                      942

<210>   180
<211>   314
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   magnesium transporter, CorA family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902214 (e-177)

<400>   180
Met Lys Gln Val Phe Leu Ser Thr Thr Thr Glu Phe Lys Glu Ile Asp 
1               5                   10                  15      

Thr Leu Glu Pro Gly Thr Trp Ile Asn Leu Val Asn Pro Thr Gln Asn 
            20                  25                  30          

Glu Ser Leu Glu Ile Ala Asn Thr Phe Asp Ile Asp Ile Ala Asp Leu 
        35                  40                  45              

Arg Ala Pro Leu Asp Ala Glu Glu Met Ser Arg Ile Thr Ile Glu Asp 
    50                  55                  60                  

Glu Tyr Thr Leu Ile Ile Val Asp Val Pro Val Thr Glu Glu Arg Asn 
65                  70                  75                  80  

Asn Arg Thr Tyr Tyr Val Thr Ile Pro Leu Gly Ile Ile Ile Thr Glu 
                85                  90                  95      

Glu Thr Ile Ile Thr Thr Cys Leu Glu Pro Leu Pro Val Leu Asp Val 
            100                 105                 110         

Phe Ile Asn Arg Arg Leu Arg Asn Phe Tyr Thr Phe Met Arg Ser Arg 
        115                 120                 125             

Phe Ile Phe Gln Ile Leu Tyr Arg Asn Ala Glu Leu Tyr Leu Thr Ala 
    130                 135                 140                 

Leu Arg Ser Ile Asp Arg Lys Ser Glu Gln Ile Glu Ser Gln Leu His 
145                 150                 155                 160 

Gln Ser Thr Arg Asn Glu Glu Leu Ile Glu Leu Met Glu Leu Glu Lys 
                165                 170                 175     

Thr Ile Val Tyr Phe Lys Ala Ser Leu Lys Thr Asn Glu Arg Val Ile 
            180                 185                 190         

Lys Lys Leu Thr Ser Ser Thr Ser Asn Ile Lys Lys Tyr Leu Glu Asp 
        195                 200                 205             

Glu Asp Leu Leu Glu Asp Thr Leu Ile Glu Thr Gln Gln Ala Ile Glu 
    210                 215                 220                 

Met Ala Asp Ile Tyr Gly Asn Val Leu His Ser Met Thr Glu Thr Phe 
225                 230                 235                 240 

Ala Ser Ile Ile Ser Asn Asn Gln Asn Asn Ile Met Lys Thr Leu Ala 
                245                 250                 255     

Leu Val Thr Ile Val Met Ser Ile Pro Thr Met Val Phe Ser Ala Tyr 
            260                 265                 270         

Gly Met Asn Phe Lys Asp Asn Glu Ile Pro Leu Asn Gly Glu Pro Asn 
        275                 280                 285             

Ala Phe Trp Leu Ile Val Phe Ile Ala Phe Ala Met Ser Val Ser Leu 
    290                 295                 300                 

Thr Leu Tyr Leu Ile His Lys Lys Trp Phe 
305                 310                 

<210>   181
<211>   2862
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   181
atggtaagca ataatggact agaaagaaca aagatgcaag ataaaattgt cattcatggg   60
gcgcgtgccc ataatttaaa aaatattgat gtggagattc cgcgagacaa gttggttgtc   120
gtgactggct tgtcaggttc agggaagtcc agtctggctt ttgatactct ctatgcggag   180
ggacaacgtc gctatgtaga gagtttgtcc gcctacgctc gtcagttctt gggaaatatg   240
gaaaaaccag atgtagatgc cattgatggt ctcagcccag ctatttccat cgaccagaaa   300
acgactagta aaaatcctcg ctcgacggtg ggaacgacga ctgaaatcaa tgactatctg   360
cgtctcctct acgcacgtgt ggggacgcct tactgtatca acggacatgg agctatcaat   420
gcttcttctg tggagcaaat cgttgataag gttttggagt tacctgaacg ccagcgcttg   480
cagatcttgg ctcctgtcat ccgcaagaaa aaaggccaac ataagagtgt tatcgagaag   540
gttcagaaag acgggtatgt tcgtgtccgt gtggatgggg aagtctatga tgtgaccgaa   600
gtgccagagt tgtctaagag caagcaacac aatatcgatg tcgtggttga ccgtattgtt   660
atcaaggagg gcattcgtag tcgtctcttt gattccattg aggctgccct tcgtattgca   720
gaaggttatg tcattatcga caccatggac gactcggagt tgttgttctc tgagcattat   780
gcctgtccag tttgtggttt tactgtccca gagttagagc ctcgtctctt ttctttcaat   840
gctccttttg gctcttgtag tgagtgtgac ggcttgggca tcaagctgga ggtggatact   900
gatttggtag tgccagatgc tagcaaaacc ttacgtgagg gagcgctagc accttggaat   960
cctatctcat ccaactacta tccaaacatg ttagagcagg ccatgaaagt ctttggagtg   1020
gctatggata agccttttga ggacctgtca gaagaagata agaacttgat tctctatggg   1080
tcagatggta aggaattcca tttccactat gagaatgaat ttggtggcgt gcgcgatatc   1140
gacattccgt ttgagggagt tatcaataat atcaaacgtc gttaccatga aaccaatagc   1200
gattacactc gcactcagat gcgtctctac atgaatgagc tgacctgcgg aacctgtcaa   1260
ggctatcgtc tcaatgacca ggccttgtct gtccgtgtgg gcggccagca agggccacat   1320
attggagaaa tctcagacct gtctatcgct gaccacttgg acttggtgag ccagttaact   1380
ttgtctgaaa atgaagccat cattgctcgt cccattctca aggaaatcaa ggatcgtttg   1440
accttcctta ataatgtggg tcttaactat ctaaccctgt cacgttcagc aggaaccctt   1500
tcaggtgggg aaagtcagcg cattcgtttg gcaacccaga ttggttccaa cctatcaggt   1560
gtcctctata tcctagacga gccgtcaatc ggtcttcacc agagggacaa tgatcgcctg   1620
attgccagtc tgaaaaagat gcgtgacttg ggcaatactc ttatcgtggt ggaacacgac   1680
gaagatacca tgcgtgaggc tgattatctg attgacgttg gtcctggtgc cggtgttttt   1740
ggtggtgaga ttgttgcagc aggtacacct aagcaagtgg ctcgcaacag caagtctatc   1800
acaggtcagt acttgtcagg caaacgtgtc atcccagtac cagaagagcg ccgtgtcgga   1860
aatggtcgtt ttattgaagt gataggagcg cgtgagaaca acttgcaaaa tgtcacggct   1920
cgctttccac taggaaaatt tatcgcagtg acaggtgtgt cgggttcagg gaaatcgact   1980
ctaatcaaca gcattctcaa aaaagccatt gcccagaagc tcaaccgtaa ttcagacaaa   2040
cctggtaagt ttaagactat tacagggatt gagcatgtcg accgtttgat tgatattgac   2100
cagagcccta tcggacggac gccgaggtct aacccagcta cctatacagg agtttttgac   2160
gatatacgtg acctttttgc tcagacaaat gaagccaaga ttcgaggcta caagaagggg   2220
cgcttcagtt tcaacgtcaa gggaggtcgc tgtgaagctt gctcaggtga cgggattatc   2280
aagattgaga tgcacttctt gccagatgtt tatgtggctt gtgaagtttg ccacggaacc   2340
cgctataaca gtgaaaccct agaagttcac tacaaggaaa agaatatttc gcaggtcttg   2400
gatatgacgg tcaacgatgc ggtagaattt ttccaacaca ttccgaaaat tcaacgcaaa   2460
ctccagacca tcaaggatgt agggctaggc tatgtgacct tgggacagcc agctaccacc   2520
ctttctgggg gagaagccca acgtatgaag ttagctagcg aactccacaa acgatcgaca   2580
ggaaaatctt tctacattct ggatgagccg acgacagggc ttcatacaga ggacattgct   2640
cgcctgctca aggttttagc tcgctttgta gacgatggca atacagtcct cgtcatcgag   2700
cacaatctgg atgttatcaa gacggcagac catatcattg acttgggacc tgagggcggt   2760
gtcggtggtg gaaccatcat cgtaacagga actccagaag aagtagctgc caacgaagcc   2820
agctatacag gacactattt gaaaggaaag ttacatcatg aa                      2862

<210>   182
<211>   954
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   excinuclease ABC, subunit A (uvrA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902215 (0.E+01)

<400>   182
Met Val Ser Asn Asn Gly Leu Glu Arg Thr Lys Met Gln Asp Lys Ile 
1               5                   10                  15      

Val Ile His Gly Ala Arg Ala His Asn Leu Lys Asn Ile Asp Val Glu 
            20                  25                  30          

Ile Pro Arg Asp Lys Leu Val Val Val Thr Gly Leu Ser Gly Ser Gly 
        35                  40                  45              

Lys Ser Ser Leu Ala Phe Asp Thr Leu Tyr Ala Glu Gly Gln Arg Arg 
    50                  55                  60                  

Tyr Val Glu Ser Leu Ser Ala Tyr Ala Arg Gln Phe Leu Gly Asn Met 
65                  70                  75                  80  

Glu Lys Pro Asp Val Asp Ala Ile Asp Gly Leu Ser Pro Ala Ile Ser 
                85                  90                  95      

Ile Asp Gln Lys Thr Thr Ser Lys Asn Pro Arg Ser Thr Val Gly Thr 
            100                 105                 110         

Thr Thr Glu Ile Asn Asp Tyr Leu Arg Leu Leu Tyr Ala Arg Val Gly 
        115                 120                 125             

Thr Pro Tyr Cys Ile Asn Gly His Gly Ala Ile Asn Ala Ser Ser Val 
    130                 135                 140                 


Glu Gln Ile Val Asp Lys Val Leu Glu Leu Pro Glu Arg Gln Arg Leu 
145                 150                 155                 160 

Gln Ile Leu Ala Pro Val Ile Arg Lys Lys Lys Gly Gln His Lys Ser 
                165                 170                 175     

Val Ile Glu Lys Val Gln Lys Asp Gly Tyr Val Arg Val Arg Val Asp 
            180                 185                 190         

Gly Glu Val Tyr Asp Val Thr Glu Val Pro Glu Leu Ser Lys Ser Lys 
        195                 200                 205             

Gln His Asn Ile Asp Val Val Val Asp Arg Ile Val Ile Lys Glu Gly 
    210                 215                 220                 

Ile Arg Ser Arg Leu Phe Asp Ser Ile Glu Ala Ala Leu Arg Ile Ala 
225                 230                 235                 240 

Glu Gly Tyr Val Ile Ile Asp Thr Met Asp Asp Ser Glu Leu Leu Phe 
                245                 250                 255     

Ser Glu His Tyr Ala Cys Pro Val Cys Gly Phe Thr Val Pro Glu Leu 
            260                 265                 270         

Glu Pro Arg Leu Phe Ser Phe Asn Ala Pro Phe Gly Ser Cys Ser Glu 
        275                 280                 285             

Cys Asp Gly Leu Gly Ile Lys Leu Glu Val Asp Thr Asp Leu Val Val 
    290                 295                 300                 

Pro Asp Ala Ser Lys Thr Leu Arg Glu Gly Ala Leu Ala Pro Trp Asn 
305                 310                 315                 320 

Pro Ile Ser Ser Asn Tyr Tyr Pro Asn Met Leu Glu Gln Ala Met Lys 
                325                 330                 335     

Val Phe Gly Val Ala Met Asp Lys Pro Phe Glu Asp Leu Ser Glu Glu 
            340                 345                 350         

Asp Lys Asn Leu Ile Leu Tyr Gly Ser Asp Gly Lys Glu Phe His Phe 
        355                 360                 365             

His Tyr Glu Asn Glu Phe Gly Gly Val Arg Asp Ile Asp Ile Pro Phe 
    370                 375                 380                 

Glu Gly Val Ile Asn Asn Ile Lys Arg Arg Tyr His Glu Thr Asn Ser 
385                 390                 395                 400 

Asp Tyr Thr Arg Thr Gln Met Arg Leu Tyr Met Asn Glu Leu Thr Cys 
                405                 410                 415     

Gly Thr Cys Gln Gly Tyr Arg Leu Asn Asp Gln Ala Leu Ser Val Arg 
            420                 425                 430         

Val Gly Gly Gln Gln Gly Pro His Ile Gly Glu Ile Ser Asp Leu Ser 
        435                 440                 445             

Ile Ala Asp His Leu Asp Leu Val Ser Gln Leu Thr Leu Ser Glu Asn 
    450                 455                 460                 

Glu Ala Ile Ile Ala Arg Pro Ile Leu Lys Glu Ile Lys Asp Arg Leu 
465                 470                 475                 480 

Thr Phe Leu Asn Asn Val Gly Leu Asn Tyr Leu Thr Leu Ser Arg Ser 
                485                 490                 495     

Ala Gly Thr Leu Ser Gly Gly Glu Ser Gln Arg Ile Arg Leu Ala Thr 
            500                 505                 510         

Gln Ile Gly Ser Asn Leu Ser Gly Val Leu Tyr Ile Leu Asp Glu Pro 
        515                 520                 525             

Ser Ile Gly Leu His Gln Arg Asp Asn Asp Arg Leu Ile Ala Ser Leu 
    530                 535                 540                 

Lys Lys Met Arg Asp Leu Gly Asn Thr Leu Ile Val Val Glu His Asp 
545                 550                 555                 560 

Glu Asp Thr Met Arg Glu Ala Asp Tyr Leu Ile Asp Val Gly Pro Gly 
                565                 570                 575     

Ala Gly Val Phe Gly Gly Glu Ile Val Ala Ala Gly Thr Pro Lys Gln 
            580                 585                 590         

Val Ala Arg Asn Ser Lys Ser Ile Thr Gly Gln Tyr Leu Ser Gly Lys 
        595                 600                 605             

Arg Val Ile Pro Val Pro Glu Glu Arg Arg Val Gly Asn Gly Arg Phe 
    610                 615                 620                 

Ile Glu Val Ile Gly Ala Arg Glu Asn Asn Leu Gln Asn Val Thr Ala 
625                 630                 635                 640 

Arg Phe Pro Leu Gly Lys Phe Ile Ala Val Thr Gly Val Ser Gly Ser 
                645                 650                 655     

Gly Lys Ser Thr Leu Ile Asn Ser Ile Leu Lys Lys Ala Ile Ala Gln 
            660                 665                 670         

Lys Leu Asn Arg Asn Ser Asp Lys Pro Gly Lys Phe Lys Thr Ile Thr 
        675                 680                 685             

Gly Ile Glu His Val Asp Arg Leu Ile Asp Ile Asp Gln Ser Pro Ile 
    690                 695                 700                 

Gly Arg Thr Pro Arg Ser Asn Pro Ala Thr Tyr Thr Gly Val Phe Asp 
705                 710                 715                 720 

Asp Ile Arg Asp Leu Phe Ala Gln Thr Asn Glu Ala Lys Ile Arg Gly 
                725                 730                 735     

Tyr Lys Lys Gly Arg Phe Ser Phe Asn Val Lys Gly Gly Arg Cys Glu 
            740                 745                 750         

Ala Cys Ser Gly Asp Gly Ile Ile Lys Ile Glu Met His Phe Leu Pro 
        755                 760                 765             

Asp Val Tyr Val Ala Cys Glu Val Cys His Gly Thr Arg Tyr Asn Ser 
    770                 775                 780                 

Glu Thr Leu Glu Val His Tyr Lys Glu Lys Asn Ile Ser Gln Val Leu 
785                 790                 795                 800 

Asp Met Thr Val Asn Asp Ala Val Glu Phe Phe Gln His Ile Pro Lys 
                805                 810                 815     

Ile Gln Arg Lys Leu Gln Thr Ile Lys Asp Val Gly Leu Gly Tyr Val 
            820                 825                 830         

Thr Leu Gly Gln Pro Ala Thr Thr Leu Ser Gly Gly Glu Ala Gln Arg 
        835                 840                 845             

Met Lys Leu Ala Ser Glu Leu His Lys Arg Ser Thr Gly Lys Ser Phe 
    850                 855                 860                 

Tyr Ile Leu Asp Glu Pro Thr Thr Gly Leu His Thr Glu Asp Ile Ala 
865                 870                 875                 880 

Arg Leu Leu Lys Val Leu Ala Arg Phe Val Asp Asp Gly Asn Thr Val 
                885                 890                 895     

Leu Val Ile Glu His Asn Leu Asp Val Ile Lys Thr Ala Asp His Ile 
            900                 905                 910         

Ile Asp Leu Gly Pro Glu Gly Gly Val Gly Gly Gly Thr Ile Ile Val 
        915                 920                 925             

Thr Gly Thr Pro Glu Glu Val Ala Ala Asn Glu Ala Ser Tyr Thr Gly 
    930                 935                 940                 

His Tyr Leu Lys Gly Lys Leu His His Glu 
945                 950                 

<210>   183
<211>   1059
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   183
atgaataaac gcgtacaagc atttctagct aaaatgcaag aaaaagaact agatggtatc   60
atcatcaaca atcttaaaaa cgtctattat ttgactggtt tttggggctc aaacggaaca   120
gtctttatca gtcgtgaccg tcaggtctta gtgacagact ctcgctatat catcgcagct   180
aagcaagaaa ccagtggttt tgagattgtg gctgatcgtg atgaattggc tgtcattgca   240
ggaattgtta aggacatggg cttgactcgt atcggttttg aagatgagat ttcagtgtct   300
tattaccacc gtatgcaggc agcttttgca ggtttgaact tgcttccaca aactcagttt   360
gtggaaggtc ttcgtatgat taaggatgag gcagagattg cagcgattcg caaggcttgt   420
tctatctcag accaagcttt ccgcgatgcg cttgacttta tcaaaccagg aaaaactgaa   480
attgagattg ccaacttcct tgatttccgc atgcgtgagt tgggagcatc tggcttatct   540
tttgatacga tcctagctag cggtatcaat tcttctaaac cccatgccca tccaatgcac   600
aaaccagtgg agttgggaga agccatcacc atggacttcg gctgtctcta tgaccactat   660
gtcagtgata tgacccggac tatctatcta gggcatgtta gcgatgagca ggcagagatt   720
tacaatacgg ttctaaaagc taaccaagcc ttgattgacc aagctaaggc aggcttaggt   780
ttccgtgact ttgacaaaat ccctcgtgat attatcattg aggcaggtta tggtgactac   840
tttactcacg gcattggcca cggtattggt ctggatatcc atgaggaacc ctactttagt   900
cagacttcta cagaaactat taagacaggt atggccttga ccgatgaacc aggtatctat   960
atcgaaggca aatatggcgt tcgtatcgag gatgatatcc tgattacaga gacaggttgt   1020
gaattattga ccctagctcc aaaagagttg atagtcatt                          1059


<210>   184
<211>   353
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidase M24 family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902216 (0.E+01)

<400>   184
Met Asn Lys Arg Val Gln Ala Phe Leu Ala Lys Met Gln Glu Lys Glu 
1               5                   10                  15      

Leu Asp Gly Ile Ile Ile Asn Asn Leu Lys Asn Val Tyr Tyr Leu Thr 
            20                  25                  30          

Gly Phe Trp Gly Ser Asn Gly Thr Val Phe Ile Ser Arg Asp Arg Gln 
        35                  40                  45              

Val Leu Val Thr Asp Ser Arg Tyr Ile Ile Ala Ala Lys Gln Glu Thr 
    50                  55                  60                  

Ser Gly Phe Glu Ile Val Ala Asp Arg Asp Glu Leu Ala Val Ile Ala 
65                  70                  75                  80  

Gly Ile Val Lys Asp Met Gly Leu Thr Arg Ile Gly Phe Glu Asp Glu 
                85                  90                  95      

Ile Ser Val Ser Tyr Tyr His Arg Met Gln Ala Ala Phe Ala Gly Leu 
            100                 105                 110         

Asn Leu Leu Pro Gln Thr Gln Phe Val Glu Gly Leu Arg Met Ile Lys 
        115                 120                 125             

Asp Glu Ala Glu Ile Ala Ala Ile Arg Lys Ala Cys Ser Ile Ser Asp 
    130                 135                 140                 

Gln Ala Phe Arg Asp Ala Leu Asp Phe Ile Lys Pro Gly Lys Thr Glu 
145                 150                 155                 160 

Ile Glu Ile Ala Asn Phe Leu Asp Phe Arg Met Arg Glu Leu Gly Ala 
                165                 170                 175     

Ser Gly Leu Ser Phe Asp Thr Ile Leu Ala Ser Gly Ile Asn Ser Ser 
            180                 185                 190         

Lys Pro His Ala His Pro Met His Lys Pro Val Glu Leu Gly Glu Ala 
        195                 200                 205             

Ile Thr Met Asp Phe Gly Cys Leu Tyr Asp His Tyr Val Ser Asp Met 
    210                 215                 220                 

Thr Arg Thr Ile Tyr Leu Gly His Val Ser Asp Glu Gln Ala Glu Ile 
225                 230                 235                 240 

Tyr Asn Thr Val Leu Lys Ala Asn Gln Ala Leu Ile Asp Gln Ala Lys 
                245                 250                 255     

Ala Gly Leu Gly Phe Arg Asp Phe Asp Lys Ile Pro Arg Asp Ile Ile 
            260                 265                 270         

Ile Glu Ala Gly Tyr Gly Asp Tyr Phe Thr His Gly Ile Gly His Gly 
        275                 280                 285             

Ile Gly Leu Asp Ile His Glu Glu Pro Tyr Phe Ser Gln Thr Ser Thr 
    290                 295                 300                 

Glu Thr Ile Lys Thr Gly Met Ala Leu Thr Asp Glu Pro Gly Ile Tyr 
305                 310                 315                 320 

Ile Glu Gly Lys Tyr Gly Val Arg Ile Glu Asp Asp Ile Leu Ile Thr 
                325                 330                 335     

Glu Thr Gly Cys Glu Leu Leu Thr Leu Ala Pro Lys Glu Leu Ile Val 
            340                 345                 350         

Ile 
    

<210>   185
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   185
ttgtcaagaa aaaagtacga aaatgacgaa aaaagtcaaa aaaaattaaa aataggtcgc   60
aagtcggatg ttttttatgg tataatagac                                    90


<210>   186
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   186
Met Ser Arg Lys Lys Tyr Glu Asn Asp Glu Lys Ser Gln Lys Lys Leu 
1               5                   10                  15      

Lys Ile Gly Arg Lys Ser Asp Val Phe Tyr Gly Ile Ile Asp 
            20                  25                  30  

<210>   187
<211>   396
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   187
atgattaaaa tttatacagt ctcaagttgt actagctgta aaaaagcaaa aacctggctc   60
aatgcccacc agttaagtta taaagaacaa aaccttggta aagaaggaat tacgagagaa   120
gaattactgg atattctaac caaaacagat aacggaatag ccagcatcgt ttcgtctaaa   180
aatcgctatg ccaaagccct tggagtggat attgaagatt tgagtgtcaa tgaagttctc   240
aatctgatta tggaaacacc gagaatttta aagagcccaa tccttgtaga tgaaaaacgc   300
ctgcaagttg gctacaagga agacgatatt cgtgccttcc taccacgctc tgtccgtaat   360
gtagaaaatg cagaagcacg tttgcgtgca gctcta                             396

<210>   188
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (Arsenate reductase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902217 (2.E-70)

<400>   188
Met Ile Lys Ile Tyr Thr Val Ser Ser Cys Thr Ser Cys Lys Lys Ala 
1               5                   10                  15      

Lys Thr Trp Leu Asn Ala His Gln Leu Ser Tyr Lys Glu Gln Asn Leu 
            20                  25                  30          

Gly Lys Glu Gly Ile Thr Arg Glu Glu Leu Leu Asp Ile Leu Thr Lys 
        35                  40                  45              

Thr Asp Asn Gly Ile Ala Ser Ile Val Ser Ser Lys Asn Arg Tyr Ala 
    50                  55                  60                  

Lys Ala Leu Gly Val Asp Ile Glu Asp Leu Ser Val Asn Glu Val Leu 
65                  70                  75                  80  

Asn Leu Ile Met Glu Thr Pro Arg Ile Leu Lys Ser Pro Ile Leu Val 
                85                  90                  95      

Asp Glu Lys Arg Leu Gln Val Gly Tyr Lys Glu Asp Asp Ile Arg Ala 
            100                 105                 110         

Phe Leu Pro Arg Ser Val Arg Asn Val Glu Asn Ala Glu Ala Arg Leu 
        115                 120                 125             

Arg Ala Ala Leu 
    130         

<210>   189
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   189
atgcagaagc acgtttgcgt gcagctctat aaacatcaag gctgggagca cttcccagtc   60
ttattctatt ttaatttcaa aaagaaagaa gaaagaaatg aaaaaaatag ttcttgt      117

<210>   190
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   190
Met Gln Lys His Val Cys Val Gln Leu Tyr Lys His Gln Gly Trp Glu 
1               5                   10                  15      

His Phe Pro Val Leu Phe Tyr Phe Asn Phe Lys Lys Lys Glu Glu Arg 
            20                  25                  30          

Asn Glu Lys Asn Ser Ser Cys 
        35                  

<210>   191
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   191
atgaaaaaaa tagttcttgt tagtctagct ttcctttttg tcctggttgg ttgcggacag   60
aaaaaagaaa ctggaccagc tacaaaaaca gaaaaagata cgcttcagtc ggcattgcca   120
gttattgaaa atgctgagaa gaatacagtt gtaactaaga ctttggtctt gcccaagtca   180
gatgatggta gccagcagac acaaacaatt acttacaaag acaagacttt tttgagtcta   240
gctatccaac aaaaacgtcc agtctctgat gagttgaaga cttatattga ccaacatgga   300
gtggaggaaa ctcaaaaagc tcttcttgaa gcggaggaga aggataagtc tatcattgaa   360
gctcgtaaat tggcaggttt caaacttgaa acaaaactat tgagcgcaac ggaacttcaa   420
acaacgacta gttttgattt tcaagttctg gatgtcaaga aggcttccca gttggaacat   480
ctgaagaata ttggtttgga aaatcttttg aaaaatgaac caagcaaata tatttcagat   540
agattggcaa atggcgcgac agaacaa                                       567

<210>   192
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902218 (e-101)

<400>   192
Met Lys Lys Ile Val Leu Val Ser Leu Ala Phe Leu Phe Val Leu Val 
1               5                   10                  15      

Gly Cys Gly Gln Lys Lys Glu Thr Gly Pro Ala Thr Lys Thr Glu Lys 
            20                  25                  30          

Asp Thr Leu Gln Ser Ala Leu Pro Val Ile Glu Asn Ala Glu Lys Asn 
        35                  40                  45              

Thr Val Val Thr Lys Thr Leu Val Leu Pro Lys Ser Asp Asp Gly Ser 
    50                  55                  60                  

Gln Gln Thr Gln Thr Ile Thr Tyr Lys Asp Lys Thr Phe Leu Ser Leu 
65                  70                  75                  80  

Ala Ile Gln Gln Lys Arg Pro Val Ser Asp Glu Leu Lys Thr Tyr Ile 
                85                  90                  95      

Asp Gln His Gly Val Glu Glu Thr Gln Lys Ala Leu Leu Glu Ala Glu 
            100                 105                 110         

Glu Lys Asp Lys Ser Ile Ile Glu Ala Arg Lys Leu Ala Gly Phe Lys 
        115                 120                 125             

Leu Glu Thr Lys Leu Leu Ser Ala Thr Glu Leu Gln Thr Thr Thr Ser 
    130                 135                 140                 

Phe Asp Phe Gln Val Leu Asp Val Lys Lys Ala Ser Gln Leu Glu His 
145                 150                 155                 160 

Leu Lys Asn Ile Gly Leu Glu Asn Leu Leu Lys Asn Glu Pro Ser Lys 
                165                 170                 175     

Tyr Ile Ser Asp Arg Leu Ala Asn Gly Ala Thr Glu Gln 
            180                 185                 

<210>   193
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   193
atgggattta ctgaagaaac agtacgtttt aaattggacg attccaataa aaaagaaatt   60
agcgaaactt tgacagatgt ttatgcttcg ttgaacgata agggttacaa cccaattaac   120
caaatcgtag gttacgtatt gagtggagac cctgcctacg ttcctcgtta taataatgca   180
cgaaatcaaa tccgtaagta tgagcgtgat gaaatcgttg aggaattggt tcgctactac   240
ctcaaaggac aaggagtcga tcta                                          264

<210>   194
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902219 (1.E-47)

<400>   194
Met Gly Phe Thr Glu Glu Thr Val Arg Phe Lys Leu Asp Asp Ser Asn 
1               5                   10                  15      

Lys Lys Glu Ile Ser Glu Thr Leu Thr Asp Val Tyr Ala Ser Leu Asn 
            20                  25                  30          

Asp Lys Gly Tyr Asn Pro Ile Asn Gln Ile Val Gly Tyr Val Leu Ser 
        35                  40                  45              

Gly Asp Pro Ala Tyr Val Pro Arg Tyr Asn Asn Ala Arg Asn Gln Ile 
    50                  55                  60                  

Arg Lys Tyr Glu Arg Asp Glu Ile Val Glu Glu Leu Val Arg Tyr Tyr 
65                  70                  75                  80  

Leu Lys Gly Gln Gly Val Asp Leu 
                85              

<210>   195
<211>   246
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   195
atgagaatta tgggattgga cgtcggttca aaaacggtag gggtggcgat tagcgatccg   60
cttggtttta cagctcaagg gcttgaaatc atccagataa atgaagaaca aggccaattt   120
ggttttgacc gcgttaagga attggttgat acttacaagg tggaacgatt tgtagtgggc   180
ttgcctaaaa acatgaacaa tacaagtgga ccgcgcgtag aagctagtca agctacggag   240
caaagc                                                              246

<210>   196
<211>   82
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, FRAMESHIFT

<400>   196
Met Arg Ile Met Gly Leu Asp Val Gly Ser Lys Thr Val Gly Val Ala 
1               5                   10                  15      

Ile Ser Asp Pro Leu Gly Phe Thr Ala Gln Gly Leu Glu Ile Ile Gln 
            20                  25                  30          

Ile Asn Glu Glu Gln Gly Gln Phe Gly Phe Asp Arg Val Lys Glu Leu 
        35                  40                  45              

Val Asp Thr Tyr Lys Val Glu Arg Phe Val Val Gly Leu Pro Lys Asn 
    50                  55                  60                  

Met Asn Asn Thr Ser Gly Pro Arg Val Glu Ala Ser Gln Ala Thr Glu 
65                  70                  75                  80  

Gln Ser 
        

<210>   197
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   197
ttgacaacag tggctgctga gcgcatgttg attgaacaag cagatatcag tcgcaataag   60
cgcaagaaag tcattgataa gttagcagct cagctgattt tacaaaatta tttagataga   120
aaattt                                                              126

<210>   198
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, FRAMESHIFT

<400>   198
Met Thr Thr Val Ala Ala Glu Arg Met Leu Ile Glu Gln Ala Asp Ile 
1               5                   10                  15      

Ser Arg Asn Lys Arg Lys Lys Val Ile Asp Lys Leu Ala Ala Gln Leu 
            20                  25                  30          

Ile Leu Gln Asn Tyr Leu Asp Arg Lys Phe 
        35                  40          

<210>   199
<211>   303
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   199
atgtcacacg atcataacca cgaccacgaa gaacgtgaac taatcacact agtagatgag   60
caaggaaatg aaaccttgtt tgaaatcctt ttgacaattg atggaaaaga agaatttggt   120
aaaaactatg ttcttctagt accagttaac gcagaagaag acgaagacgg acaagttgaa   180
atccaagctt actcattcat cgaaaacgaa gatggaacag aaggcgaatt gcaaccaatc   240
ccagaagact cagaagacga atggaacatg attgaagaag tcttcaacag ctttatggag   300
gag                                                                 303

<210>   200
<211>   101
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902221 (2.E-56)

<400>   200
Met Ser His Asp His Asn His Asp His Glu Glu Arg Glu Leu Ile Thr 
1               5                   10                  15      

Leu Val Asp Glu Gln Gly Asn Glu Thr Leu Phe Glu Ile Leu Leu Thr 
            20                  25                  30          

Ile Asp Gly Lys Glu Glu Phe Gly Lys Asn Tyr Val Leu Leu Val Pro 
        35                  40                  45              

Val Asn Ala Glu Glu Asp Glu Asp Gly Gln Val Glu Ile Gln Ala Tyr 
    50                  55                  60                  

Ser Phe Ile Glu Asn Glu Asp Gly Thr Glu Gly Glu Leu Gln Pro Ile 
65                  70                  75                  80  

Pro Glu Asp Ser Glu Asp Glu Trp Asn Met Ile Glu Glu Val Phe Asn 
                85                  90                  95      

Ser Phe Met Glu Glu 
            100     

<210>   201
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   201
ttgaagaagt cttcaacagc tttatggagg agtgatacag tctgggagac tgtatcagcc   60
caactcccag aaatggggaa gagttggaac gtccag                             96

<210>   202
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   202
Met Lys Lys Ser Ser Thr Ala Leu Trp Arg Ser Asp Thr Val Trp Glu 
1               5                   10                  15      

Thr Val Ser Ala Gln Leu Pro Glu Met Gly Lys Ser Trp Asn Val Gln 
            20                  25                  30          


<210>   203
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   203
ttggaacgtc cagtgaacat ttttacccca actcccagaa atggggaaga gttggaacgt   60
ccagtggatg tttttagccc atattcacat tca                                93

<210>   204
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   204
Met Glu Arg Pro Val Asn Ile Phe Thr Pro Thr Pro Arg Asn Gly Glu 
1               5                   10                  15      

Glu Leu Glu Arg Pro Val Asp Val Phe Ser Pro Tyr Ser His Ser 
            20                  25                  30      

<210>   205
<211>   1248
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   205
atgtttgaag tagaagaatg gctccatagt cggattggtt tgaattttcg atcaggtttg   60
ggtcgaatgc agcaagcggt ggatttgtta ggaaatcctg agcagtctta ccctattatc   120
cacgtaacag ggactaatgg gaaaggatct accattgctt ttatgaggga attatttatg   180
gggcatggca aaaaagttgc gacctttacc tcccctcata tcgtctctat caatgaccga   240
atctgcatta atgggcagcc tatagcagac gcagacttta tccgtttgac tgatcaggtc   300
aaggagatgg agaaaacgct tctgcaaact cctgcccagt tgtccttttt tgaattgctg   360
accttggttg cttttcttta ttttagggag caggaggtgg atttggtttt attagaagtg   420
ggaattggtg gcttacttga cacgaccaat gtggtaactg gagagtttgc tgtcatcacc   480
tccattgggc ttgaccatca agaaaccttg ggtgatagtc tagaagcaat tgcagagcag   540
aaagctggta ttttcaaggc tggtaagaag gcagtgattg cgaaattgcc tccagaagct   600
aggcttgcct gtcagaaaaa agccgaatct ttagctgtta acctttatca ggcaggtcaa   660
gattttttaa tgctgaatgg tgatttttca agctctttac taaatctttc acagctgaac   720
ataggcttag aaggagtcta tcagcaggag aatgcagcct tggcgttgca aacttttctt   780
ctttttatga gagaaagaaa ggaagctgtt gatgaacagg ctgtaagaaa ggccttggaa   840
cagacccatt gggctggtcg cttggagcgt attcgcccac agatttattt ggatggtgct   900
cataacctcc ctgccttgac tcgcttggct gagtttatca aagaaaaaga gcaggaaggc   960
tatcgacctc aaatcctctt tggatccttg aaacgtaagg attatcaagg gatgttgggt   1020
tatctgactg aaaaattgcc tcaggtggaa ctcaaggtga ccggctttga ctatcagggg   1080
gctttggacg aaagggatgt gacaggttac gatatagttt cttcttaccg agaatttatc   1140
agcgattttg aagaaagggc agacgctcaa gacttgctgt tcgttacagg gtctctctat   1200
tttatctcag aagtacgggg ctacctgctg gaccgtgagc agataaat                1248

<210>   206
<211>   416
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydrofolate synthetase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902222 (0.E+01)

<400>   206
Met Phe Glu Val Glu Glu Trp Leu His Ser Arg Ile Gly Leu Asn Phe 
1               5                   10                  15      

Arg Ser Gly Leu Gly Arg Met Gln Gln Ala Val Asp Leu Leu Gly Asn 
            20                  25                  30          

Pro Glu Gln Ser Tyr Pro Ile Ile His Val Thr Gly Thr Asn Gly Lys 
        35                  40                  45              

Gly Ser Thr Ile Ala Phe Met Arg Glu Leu Phe Met Gly His Gly Lys 
    50                  55                  60                  

Lys Val Ala Thr Phe Thr Ser Pro His Ile Val Ser Ile Asn Asp Arg 
65                  70                  75                  80  

Ile Cys Ile Asn Gly Gln Pro Ile Ala Asp Ala Asp Phe Ile Arg Leu 
                85                  90                  95      

Thr Asp Gln Val Lys Glu Met Glu Lys Thr Leu Leu Gln Thr Pro Ala 
            100                 105                 110         

Gln Leu Ser Phe Phe Glu Leu Leu Thr Leu Val Ala Phe Leu Tyr Phe 
        115                 120                 125             

Arg Glu Gln Glu Val Asp Leu Val Leu Leu Glu Val Gly Ile Gly Gly 
    130                 135                 140                 

Leu Leu Asp Thr Thr Asn Val Val Thr Gly Glu Phe Ala Val Ile Thr 
145                 150                 155                 160 

Ser Ile Gly Leu Asp His Gln Glu Thr Leu Gly Asp Ser Leu Glu Ala 
                165                 170                 175     

Ile Ala Glu Gln Lys Ala Gly Ile Phe Lys Ala Gly Lys Lys Ala Val 
            180                 185                 190         

Ile Ala Lys Leu Pro Pro Glu Ala Arg Leu Ala Cys Gln Lys Lys Ala 
        195                 200                 205             

Glu Ser Leu Ala Val Asn Leu Tyr Gln Ala Gly Gln Asp Phe Leu Met 
    210                 215                 220                 

Leu Asn Gly Asp Phe Ser Ser Ser Leu Leu Asn Leu Ser Gln Leu Asn 
225                 230                 235                 240 

Ile Gly Leu Glu Gly Val Tyr Gln Gln Glu Asn Ala Ala Leu Ala Leu 
                245                 250                 255     

Gln Thr Phe Leu Leu Phe Met Arg Glu Arg Lys Glu Ala Val Asp Glu 
            260                 265                 270         

Gln Ala Val Arg Lys Ala Leu Glu Gln Thr His Trp Ala Gly Arg Leu 
        275                 280                 285             

Glu Arg Ile Arg Pro Gln Ile Tyr Leu Asp Gly Ala His Asn Leu Pro 
    290                 295                 300                 

Ala Leu Thr Arg Leu Ala Glu Phe Ile Lys Glu Lys Glu Gln Glu Gly 
305                 310                 315                 320 

Tyr Arg Pro Gln Ile Leu Phe Gly Ser Leu Lys Arg Lys Asp Tyr Gln 
                325                 330                 335     

Gly Met Leu Gly Tyr Leu Thr Glu Lys Leu Pro Gln Val Glu Leu Lys 
            340                 345                 350         

Val Thr Gly Phe Asp Tyr Gln Gly Ala Leu Asp Glu Arg Asp Val Thr 
        355                 360                 365             

Gly Tyr Asp Ile Val Ser Ser Tyr Arg Glu Phe Ile Ser Asp Phe Glu 
    370                 375                 380                 

Glu Arg Ala Asp Ala Gln Asp Leu Leu Phe Val Thr Gly Ser Leu Tyr 
385                 390                 395                 400 

Phe Ile Ser Glu Val Arg Gly Tyr Leu Leu Asp Arg Glu Gln Ile Asn 
                405                 410                 415     


<210>   207
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   207
ttgcagtatt ggtattctgt tgagcaggtt gttggacctg ctgctgagca acaggctgtt   60
gaacctgttg agctctttgt gaacaagcta ctaagagac                          99

<210>   208
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   208
Met Gln Tyr Trp Tyr Ser Val Glu Gln Val Val Gly Pro Ala Ala Glu 
1               5                   10                  15      

Gln Gln Ala Val Glu Pro Val Glu Leu Phe Val Asn Lys Leu Leu Arg 
            20                  25                  30          

Asp 
    

<210>   209
<211>   543
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   209
ttgactccat tttttgaact tgttatacta ggggaattgc tggttagaga aaatttctct   60
aaattggtag cagaaaggaa attcatcatg aaattaaaaa gattcacact ttctcttgct   120
tctctagcaa gttttagtct cttagtagct tgttcacaaa gagctcaaca ggttcaacag   180
cctgttgctc agcagcaggt ccaacaacct gctcaacaga ataccaatac tgcaaatgca   240
ggaggtaacc aaaatcaagc ggctccagta caaaaccaac ctgttgctca accgaccgat   300
attgatggga cttatactgg tcaggatgac ggagaccgta tcactttagt ggtaactgga   360
acgactggta catggactga gctcgaatct gacggggatc agaaagtcaa acaggttaca   420
ttggattcag caaatcaacg catgattatt ggcgatgatg tcaaaattta cactgtaaac   480
ggtaatcaaa tcgtcgtaga tgatatggat agagacccat cggaccaaat cgttttaact   540
aaa                                                                 543

<210>   210
<211>   181
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   hypothetical protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902223 (9.E-76)

<400>   210
Met Thr Pro Phe Phe Glu Leu Val Ile Leu Gly Glu Leu Leu Val Arg 
1               5                   10                  15      

Glu Asn Phe Ser Lys Leu Val Ala Glu Arg Lys Phe Ile Met Lys Leu 
            20                  25                  30          

Lys Arg Phe Thr Leu Ser Leu Ala Ser Leu Ala Ser Phe Ser Leu Leu 
        35                  40                  45              

Val Ala Cys Ser Gln Arg Ala Gln Gln Val Gln Gln Pro Val Ala Gln 
    50                  55                  60                  

Gln Gln Val Gln Gln Pro Ala Gln Gln Asn Thr Asn Thr Ala Asn Ala 
65                  70                  75                  80  

Gly Gly Asn Gln Asn Gln Ala Ala Pro Val Gln Asn Gln Pro Val Ala 
                85                  90                  95      

Gln Pro Thr Asp Ile Asp Gly Thr Tyr Thr Gly Gln Asp Asp Gly Asp 
            100                 105                 110         

Arg Ile Thr Leu Val Val Thr Gly Thr Thr Gly Thr Trp Thr Glu Leu 
        115                 120                 125             

Glu Ser Asp Gly Asp Gln Lys Val Lys Gln Val Thr Leu Asp Ser Ala 
    130                 135                 140                 

Asn Gln Arg Met Ile Ile Gly Asp Asp Val Lys Ile Tyr Thr Val Asn 
145                 150                 155                 160 

Gly Asn Gln Ile Val Val Asp Asp Met Asp Arg Asp Pro Ser Asp Gln 
                165                 170                 175     

Ile Val Leu Thr Lys 
            180     

<210>   211
<211>   1530
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   211
atgaaatata ggaaatttca attattgatg tccaagtatg gctttagtct ttcgattatg   60
ctacttgaac tttgtcttgt ttttggtctc tttctttatt taggacgcat ggctcccatt   120
ttatggatta ctgtcctcat tctactgagt atcatcacaa tcatttcgat agtcaaccgt   180
aatacgactc ctgagaataa ggtaacctgg ttgttagtag cctttgtgcc agtatttggt   240
cccttgctct atctgatgtt tggtgaaagg cgattgtcca aaaaagaaat caaacaactg   300
aagaagctag gctctatgca tttccaagaa gcaaatagcc agctactaaa agagaaatta   360
aaagaaagtg acaaggcagc ttatggagtc atcaagtcct tattgagtat ggataccaat   420
gctgacatct atgatcaaac tgcctctaca ttttttccta acggagaagc tatgtggaaa   480
aagatggtag aagatcttaa aaaggctgag aaatttattt tcttggaata ttacattata   540
gaagaaggtt tgatgtggaa tcgcatacta gatatactag agcaaaaggt agctcagggt   600
gtagaggtta agatgctcta tgatgatatc ggctgtatgg ctactttaac aggagattat   660
gcacatcgac ttcgtcagct gggcatcgag gcccataaat tcaataaagt tattcctcgt   720
ttgacagtgg cttataataa cagagatcat agaaaaatat tgattgttga tggtcagata   780
gcctatactg gtggggtcaa tctggcagat gagtacatta accacgtcga gagatttggt   840
tattggaagg atagtggaat tcgcttagac ggactagcag taaaagctct gacacgctta   900
tttttgacca cttggtacat taatcgagga gaaattagtg attttgatca atatcattta   960
gaaaatcatt ctatcccgag tgacggttta accattccat acggaagtgg acccaagcca   1020
atttttcgag cgcaggtagg gaaaaaagtt tatcagagtt taatcaatca agcaacagaa   1080
tcggtctata ttacgacacc ttatttgatt atagattatg atttaacaga gacaatcaaa   1140
aatgcagcta tgagaggggt cgatgttcga attatcaccc cttacatacc agataagaag   1200
ttcattcagt tagtcacgag aggagcttat cccgaccttc tttctgctgg tgttcggatt   1260
tatgagtata gtccaggttt tattcatagt aagcagatgt tggtagacga agattttgcg   1320
gtggtgggga caatcaatct cgactaccgg agcttggtac accattatga aaatgcagtc   1380
ttactctata aaactccttc tataagggaa atcgcccgag attttcgaaa tatatttgca   1440
gattctcagg aagtctatcc tcattctatc aaaacgagct ggtatcaaaa gcttgtaaaa   1500
gaaatcgccc agctattcgc ccctatctta                                    1530

<210>   212
<211>   510
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cardiolipin synthetase (cls)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902224 (0.E+01)

<400>   212
Met Lys Tyr Arg Lys Phe Gln Leu Leu Met Ser Lys Tyr Gly Phe Ser 
1               5                   10                  15      

Leu Ser Ile Met Leu Leu Glu Leu Cys Leu Val Phe Gly Leu Phe Leu 
            20                  25                  30          

Tyr Leu Gly Arg Met Ala Pro Ile Leu Trp Ile Thr Val Leu Ile Leu 
        35                  40                  45              

Leu Ser Ile Ile Thr Ile Ile Ser Ile Val Asn Arg Asn Thr Thr Pro 
    50                  55                  60                  

Glu Asn Lys Val Thr Trp Leu Leu Val Ala Phe Val Pro Val Phe Gly 
65                  70                  75                  80  

Pro Leu Leu Tyr Leu Met Phe Gly Glu Arg Arg Leu Ser Lys Lys Glu 
                85                  90                  95      

Ile Lys Gln Leu Lys Lys Leu Gly Ser Met His Phe Gln Glu Ala Asn 
            100                 105                 110         

Ser Gln Leu Leu Lys Glu Lys Leu Lys Glu Ser Asp Lys Ala Ala Tyr 
        115                 120                 125             

Gly Val Ile Lys Ser Leu Leu Ser Met Asp Thr Asn Ala Asp Ile Tyr 
    130                 135                 140                 

Asp Gln Thr Ala Ser Thr Phe Phe Pro Asn Gly Glu Ala Met Trp Lys 
145                 150                 155                 160 

Lys Met Val Glu Asp Leu Lys Lys Ala Glu Lys Phe Ile Phe Leu Glu 
                165                 170                 175     

Tyr Tyr Ile Ile Glu Glu Gly Leu Met Trp Asn Arg Ile Leu Asp Ile 
            180                 185                 190         

Leu Glu Gln Lys Val Ala Gln Gly Val Glu Val Lys Met Leu Tyr Asp 
        195                 200                 205             

Asp Ile Gly Cys Met Ala Thr Leu Thr Gly Asp Tyr Ala His Arg Leu 
    210                 215                 220                 

Arg Gln Leu Gly Ile Glu Ala His Lys Phe Asn Lys Val Ile Pro Arg 
225                 230                 235                 240 

Leu Thr Val Ala Tyr Asn Asn Arg Asp His Arg Lys Ile Leu Ile Val 
                245                 250                 255     

Asp Gly Gln Ile Ala Tyr Thr Gly Gly Val Asn Leu Ala Asp Glu Tyr 
            260                 265                 270         

Ile Asn His Val Glu Arg Phe Gly Tyr Trp Lys Asp Ser Gly Ile Arg 
        275                 280                 285             

Leu Asp Gly Leu Ala Val Lys Ala Leu Thr Arg Leu Phe Leu Thr Thr 
    290                 295                 300                 

Trp Tyr Ile Asn Arg Gly Glu Ile Ser Asp Phe Asp Gln Tyr His Leu 
305                 310                 315                 320 

Glu Asn His Ser Ile Pro Ser Asp Gly Leu Thr Ile Pro Tyr Gly Ser 
                325                 330                 335     

Gly Pro Lys Pro Ile Phe Arg Ala Gln Val Gly Lys Lys Val Tyr Gln 
            340                 345                 350         

Ser Leu Ile Asn Gln Ala Thr Glu Ser Val Tyr Ile Thr Thr Pro Tyr 
        355                 360                 365             

Leu Ile Ile Asp Tyr Asp Leu Thr Glu Thr Ile Lys Asn Ala Ala Met 
    370                 375                 380                 

Arg Gly Val Asp Val Arg Ile Ile Thr Pro Tyr Ile Pro Asp Lys Lys 
385                 390                 395                 400 

Phe Ile Gln Leu Val Thr Arg Gly Ala Tyr Pro Asp Leu Leu Ser Ala 
                405                 410                 415     

Gly Val Arg Ile Tyr Glu Tyr Ser Pro Gly Phe Ile His Ser Lys Gln 
            420                 425                 430         

Met Leu Val Asp Glu Asp Phe Ala Val Val Gly Thr Ile Asn Leu Asp 
        435                 440                 445             

Tyr Arg Ser Leu Val His His Tyr Glu Asn Ala Val Leu Leu Tyr Lys 
    450                 455                 460                 

Thr Pro Ser Ile Arg Glu Ile Ala Arg Asp Phe Arg Asn Ile Phe Ala 
465                 470                 475                 480 

Asp Ser Gln Glu Val Tyr Pro His Ser Ile Lys Thr Ser Trp Tyr Gln 
                485                 490                 495     

Lys Leu Val Lys Glu Ile Ala Gln Leu Phe Ala Pro Ile Leu 
            500                 505                 510 

<210>   213
<211>   1311
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   213
ttgaacagga gaaacgatat gagtgtgtat ggtagagtag aagaagttca taaggagaat   60
cgtgaacctc tagaatacca aatcgaacaa gaatcgcatc atcgtgaatc aagtcgtctt   120
cctttggtga aaattttact atggagtacg cttgtaacgg ggataactct aggagtaccg   180
ctattactcg acttaatgag tgcacaagaa gtgcaggatt tttatgcagg ttgggcgctt   240
catcagacag ggaagattta cagcgactat tatggaagtc aaggtttgct ttattatttg   300
ctgacttacg tgagtcaggg cggatttttc tttgccatct ttgagtggtt agccttggta   360
gcaggaggat ttttcctttt tagatcagcg gacaccttga cagagcaagg agaccaagct   420
ggacatctgg tgactatttt ttacatgcta gttacaggtc ttgcttttgg tggaggctat   480
gcgactcttt tagcgcttcc tttcttattc gcagccttta gtttagttgc ggcttaccta   540
agcaatccaa gccatgataa gggatttgta cggattgggc tagctttggc aggcggattt   600
ttctttgctc ccttatcatc gctcctgttt attgctgtag tgagtttagg cttgttggtc   660
tttaaccttg ggcatagacg ctttgcgcat gggttttatc agtttcttgc agtggcttta   720
ggtttttcac ttgtctttta tccaactgcc tactatagtg ctgcaacagg aagttttggg   780
gatgcgatta gtggtattcg ttatcctatt gacagtattc gctttgattt tacttctaaa   840
attttagaga atatgttttt ttatggcttg ttgtcccttg gtttgggatt tgtggtttgt   900
atctttttag gtctctttca atccaaaccc tttaaactat acgtcatttc ggttcctgca   960
agtcttgtgg taattttagg tttgatttta cttttctttt cacaagagcc tctgcacgct   1020
tcttatttga tggtcgtctt ccctgttttc ctacttttat tggtaaccaa tattaagagt   1080
caacagaggg ggcgtagtgc tagaagaagc cgaagagaaa cgccagttag cctatggagt   1140
cgtttcttca aaggaaatct atatctgcta gtttttgggt ttgtctatct tttgtctgtt   1200
ccttttttga tgaagtttgt cctttatcca gtaccttatc aagaacgtaa tcgtcttgct   1260
gatttggtaa aagaggagac aaatacggaa gatgctatct catgcatggg a            1311

<210>   214
<211>   437
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence-induced protein Ccs4 (ccs4)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902226 (0.E+01)

<400>   214
Met Asn Arg Arg Asn Asp Met Ser Val Tyr Gly Arg Val Glu Glu Val 
1               5                   10                  15      

His Lys Glu Asn Arg Glu Pro Leu Glu Tyr Gln Ile Glu Gln Glu Ser 
            20                  25                  30          

His His Arg Glu Ser Ser Arg Leu Pro Leu Val Lys Ile Leu Leu Trp 
        35                  40                  45              

Ser Thr Leu Val Thr Gly Ile Thr Leu Gly Val Pro Leu Leu Leu Asp 
    50                  55                  60                  

Leu Met Ser Ala Gln Glu Val Gln Asp Phe Tyr Ala Gly Trp Ala Leu 
65                  70                  75                  80  


His Gln Thr Gly Lys Ile Tyr Ser Asp Tyr Tyr Gly Ser Gln Gly Leu 
                85                  90                  95      

Leu Tyr Tyr Leu Leu Thr Tyr Val Ser Gln Gly Gly Phe Phe Phe Ala 
            100                 105                 110         

Ile Phe Glu Trp Leu Ala Leu Val Ala Gly Gly Phe Phe Leu Phe Arg 
        115                 120                 125             

Ser Ala Asp Thr Leu Thr Glu Gln Gly Asp Gln Ala Gly His Leu Val 
    130                 135                 140                 

Thr Ile Phe Tyr Met Leu Val Thr Gly Leu Ala Phe Gly Gly Gly Tyr 
145                 150                 155                 160 

Ala Thr Leu Leu Ala Leu Pro Phe Leu Phe Ala Ala Phe Ser Leu Val 
                165                 170                 175     

Ala Ala Tyr Leu Ser Asn Pro Ser His Asp Lys Gly Phe Val Arg Ile 
            180                 185                 190         

Gly Leu Ala Leu Ala Gly Gly Phe Phe Phe Ala Pro Leu Ser Ser Leu 
        195                 200                 205             

Leu Phe Ile Ala Val Val Ser Leu Gly Leu Leu Val Phe Asn Leu Gly 
    210                 215                 220                 

His Arg Arg Phe Ala His Gly Phe Tyr Gln Phe Leu Ala Val Ala Leu 
225                 230                 235                 240 

Gly Phe Ser Leu Val Phe Tyr Pro Thr Ala Tyr Tyr Ser Ala Ala Thr 
                245                 250                 255     

Gly Ser Phe Gly Asp Ala Ile Ser Gly Ile Arg Tyr Pro Ile Asp Ser 
            260                 265                 270         

Ile Arg Phe Asp Phe Thr Ser Lys Ile Leu Glu Asn Met Phe Phe Tyr 
        275                 280                 285             

Gly Leu Leu Ser Leu Gly Leu Gly Phe Val Val Cys Ile Phe Leu Gly 
    290                 295                 300                 

Leu Phe Gln Ser Lys Pro Phe Lys Leu Tyr Val Ile Ser Val Pro Ala 
305                 310                 315                 320 

Ser Leu Val Val Ile Leu Gly Leu Ile Leu Leu Phe Phe Ser Gln Glu 
                325                 330                 335     

Pro Leu His Ala Ser Tyr Leu Met Val Val Phe Pro Val Phe Leu Leu 
            340                 345                 350         

Leu Leu Val Thr Asn Ile Lys Ser Gln Gln Arg Gly Arg Ser Ala Arg 
        355                 360                 365             

Arg Ser Arg Arg Glu Thr Pro Val Ser Leu Trp Ser Arg Phe Phe Lys 
    370                 375                 380                 

Gly Asn Leu Tyr Leu Leu Val Phe Gly Phe Val Tyr Leu Leu Ser Val 
385                 390                 395                 400 

Pro Phe Leu Met Lys Phe Val Leu Tyr Pro Val Pro Tyr Gln Glu Arg 
                405                 410                 415     

Asn Arg Leu Ala Asp Leu Val Lys Glu Glu Thr Asn Thr Glu Asp Ala 
            420                 425                 430         

Ile Ser Cys Met Gly 
        435         

<210>   215
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   215
atgctatctc atgcatggga tgatactgcg actctttatc gtaagagtga gcgcttgtcg   60
ccatcggcga ttttgtcccc gttgcactat acagcaactg aggaaaatcg taataagtta   120
cttaatgact tgaaagaaaa acaacctaag gtgattgtgg taaatgataa ggtggtagtc   180
tggtctgaag tggaaacact cttaaaagaa aattaccaac aagtaaagac tgattactca   240
gagtttaaag tctataaaat taaa                                          264

<210>   216
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902226 (6.E-45)

<400>   216
Met Leu Ser His Ala Trp Asp Asp Thr Ala Thr Leu Tyr Arg Lys Ser 
1               5                   10                  15      

Glu Arg Leu Ser Pro Ser Ala Ile Leu Ser Pro Leu His Tyr Thr Ala 
            20                  25                  30          


Thr Glu Glu Asn Arg Asn Lys Leu Leu Asn Asp Leu Lys Glu Lys Gln 
        35                  40                  45              

Pro Lys Val Ile Val Val Asn Asp Lys Val Val Val Trp Ser Glu Val 
    50                  55                  60                  

Glu Thr Leu Leu Lys Glu Asn Tyr Gln Gln Val Lys Thr Asp Tyr Ser 
65                  70                  75                  80  

Glu Phe Lys Val Tyr Lys Ile Lys 
                85              

<210>   217
<211>   2211
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   217
atgcatatga ttgcactaga agaaaaaatt acaattttgc caactctctt cgtcgagaaa   60
cgagatggga gacgtgttgt atttgatgtg gacaagattg acaaggctct ccacaaggcg   120
gctgacaagg ttatggatgt gacacccctg gttgaaaaat gcctcaatga tctgactgag   180
cgaattatta cagaaattca tagtcgcttt ccacagggaa ttaagattta cgaaattcaa   240
aatatcgtag aacatgaact ccttgaagcc aaagaatatg cgctggctga ggagtatatt   300
acttatcgga cacagaggga ttttgagcgc tcaaaagcga cggatatcaa ctttagtatt   360
cataaacttc tcaacaaaga ccagacagtt gtcaatgaaa acgctaataa agacagtgat   420
gtctttaaca ctcagcgtga tttgacagca gggattgttg ggaaatcaat cggactgcaa   480
atgcttccta agcacgtagc caatgcccac caaaaggggg atatccacta tcacgatttg   540
gactacagtc cctatacccc tatgaccaac tgctgtttga ttgattttaa gggtatgttg   600
gaaaatggtt ttaagattgg aaatgcagag gtagagagtc ccaagtctat ccagactgcg   660
acagcacaga tttctcaaat cattgccaac gttgcttcta gccagtacgg tggctgttca   720
gctgaccgta tcgatgaaat tttggcgcct tatgcagaga agaattatca aaaacatctc   780
aaagatgcag aagagtgggt attgcctgaa aaacaggaag attacgcttg gaagaaagcg   840
caaaaggaca tctacgatgc catgcaatct cttgagtatg aaatcaatac tctcttcact   900
tcaaatggac aaacaccttt tacttcgtta ggttttggtc tgggaaccag tcgttttgaa   960
cgagaaattc aaaaagctat tttaaacatt cgcatcaagg gtcttggttc agaacaccgt   1020
acggctatct ttcctaaact tatctttacg cttaaaagag gcctcaactt agaggaagga   1080
actcccaact atgacatcaa gcagttggct ctagagtgtg caaccaagcg gatgtatcca   1140
gacgtcttgt cttatgataa gattgttgat ttgacaggtt ctttcaaggt gcctatgggc   1200
tgccgttctt tccttcaagg gtggaaggat gaaaatggtg tagaagtcaa ttcaggtcgc   1260
atgaatctgg gtgttgtgac ggttaatctg cctcgtattg ctcttgagtc tgaaggtgat   1320
atgaataagt tctgggaaat cttcaacgag cgaatgaata tcgcagaaga tgctcttgtt   1380
taccgtgtcg aacgcactaa agaggcgaca ccagcgaatg ctcctattct ttatcagtac   1440
ggtgcttttg gccatcgtct aggtaaagaa gaaagtgttg accagctctt taagaatcgt   1500
cgtgcgaccg tttcgctggg ctatatcggc ttgtatgaag tagcgacagt tttctttggt   1560
aacagctggg aaagtaatcc agatgctaag gaattcacgc tagacatcat tcacgatatg   1620
aaacgccgtg tagaagagtg gtcagaccaa tatggctacc atttctctat ctactcaaca   1680
ccatccgaaa gtctgacaga ccgtttctgc cgactagata tagacaagtt tggctctatt   1740
cctgatatca cagacaagga atactacacc aactctttcc actacgatgt tcgtaaaaat   1800
ccaacaccgt ttgaaaaatt ggactttgag aaagtctatc cggaagcagg tgcgtcaggt   1860
ggtttcatcc attattgtga gtatccagtc cttcagcaaa atccaaaggc cttggaagct   1920
gtctgggatt atgcttatga ccgtgtaggc tatctaggca ccaatactcc gattgaccgt   1980
tgctacaagt gtgactttga aggggatttt gaaccaactg agagagggtt tgcttgtcca   2040
aactgtggca atagcgaccc taaaacagta gatgtggtga aacgaacttg tggctaccta   2100
ggtaatcctc aagcaagacc gatggtcaac gggcgtcaca aggaaatcgc tgcgcgtgtc   2160
aaacatatga atggttcaac gattaaaata gctgggcatc aagtaacaaa t            2211

<210>   218
<211>   737
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   anaerobic ribonucleoside-triphosphate reductase (nrdD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902227 (0.E+01)

<400>   218
Met His Met Ile Ala Leu Glu Glu Lys Ile Thr Ile Leu Pro Thr Leu 
1               5                   10                  15      

Phe Val Glu Lys Arg Asp Gly Arg Arg Val Val Phe Asp Val Asp Lys 
            20                  25                  30          

Ile Asp Lys Ala Leu His Lys Ala Ala Asp Lys Val Met Asp Val Thr 
        35                  40                  45              

Pro Leu Val Glu Lys Cys Leu Asn Asp Leu Thr Glu Arg Ile Ile Thr 
    50                  55                  60                  

Glu Ile His Ser Arg Phe Pro Gln Gly Ile Lys Ile Tyr Glu Ile Gln 
65                  70                  75                  80  

Asn Ile Val Glu His Glu Leu Leu Glu Ala Lys Glu Tyr Ala Leu Ala 
                85                  90                  95      

Glu Glu Tyr Ile Thr Tyr Arg Thr Gln Arg Asp Phe Glu Arg Ser Lys 
            100                 105                 110         

Ala Thr Asp Ile Asn Phe Ser Ile His Lys Leu Leu Asn Lys Asp Gln 
        115                 120                 125             

Thr Val Val Asn Glu Asn Ala Asn Lys Asp Ser Asp Val Phe Asn Thr 
    130                 135                 140                 

Gln Arg Asp Leu Thr Ala Gly Ile Val Gly Lys Ser Ile Gly Leu Gln 
145                 150                 155                 160 

Met Leu Pro Lys His Val Ala Asn Ala His Gln Lys Gly Asp Ile His 
                165                 170                 175     

Tyr His Asp Leu Asp Tyr Ser Pro Tyr Thr Pro Met Thr Asn Cys Cys 
            180                 185                 190         

Leu Ile Asp Phe Lys Gly Met Leu Glu Asn Gly Phe Lys Ile Gly Asn 
        195                 200                 205             

Ala Glu Val Glu Ser Pro Lys Ser Ile Gln Thr Ala Thr Ala Gln Ile 
    210                 215                 220                 

Ser Gln Ile Ile Ala Asn Val Ala Ser Ser Gln Tyr Gly Gly Cys Ser 
225                 230                 235                 240 

Ala Asp Arg Ile Asp Glu Ile Leu Ala Pro Tyr Ala Glu Lys Asn Tyr 
                245                 250                 255     

Gln Lys His Leu Lys Asp Ala Glu Glu Trp Val Leu Pro Glu Lys Gln 
            260                 265                 270         

Glu Asp Tyr Ala Trp Lys Lys Ala Gln Lys Asp Ile Tyr Asp Ala Met 
        275                 280                 285             

Gln Ser Leu Glu Tyr Glu Ile Asn Thr Leu Phe Thr Ser Asn Gly Gln 
    290                 295                 300                 

Thr Pro Phe Thr Ser Leu Gly Phe Gly Leu Gly Thr Ser Arg Phe Glu 
305                 310                 315                 320 

Arg Glu Ile Gln Lys Ala Ile Leu Asn Ile Arg Ile Lys Gly Leu Gly 
                325                 330                 335     

Ser Glu His Arg Thr Ala Ile Phe Pro Lys Leu Ile Phe Thr Leu Lys 
            340                 345                 350         

Arg Gly Leu Asn Leu Glu Glu Gly Thr Pro Asn Tyr Asp Ile Lys Gln 
        355                 360                 365             

Leu Ala Leu Glu Cys Ala Thr Lys Arg Met Tyr Pro Asp Val Leu Ser 
    370                 375                 380                 

Tyr Asp Lys Ile Val Asp Leu Thr Gly Ser Phe Lys Val Pro Met Gly 
385                 390                 395                 400 

Cys Arg Ser Phe Leu Gln Gly Trp Lys Asp Glu Asn Gly Val Glu Val 
                405                 410                 415     

Asn Ser Gly Arg Met Asn Leu Gly Val Val Thr Val Asn Leu Pro Arg 
            420                 425                 430         

Ile Ala Leu Glu Ser Glu Gly Asp Met Asn Lys Phe Trp Glu Ile Phe 
        435                 440                 445             

Asn Glu Arg Met Asn Ile Ala Glu Asp Ala Leu Val Tyr Arg Val Glu 
    450                 455                 460                 

Arg Thr Lys Glu Ala Thr Pro Ala Asn Ala Pro Ile Leu Tyr Gln Tyr 
465                 470                 475                 480 

Gly Ala Phe Gly His Arg Leu Gly Lys Glu Glu Ser Val Asp Gln Leu 
                485                 490                 495     

Phe Lys Asn Arg Arg Ala Thr Val Ser Leu Gly Tyr Ile Gly Leu Tyr 
            500                 505                 510         

Glu Val Ala Thr Val Phe Phe Gly Asn Ser Trp Glu Ser Asn Pro Asp 
        515                 520                 525             

Ala Lys Glu Phe Thr Leu Asp Ile Ile His Asp Met Lys Arg Arg Val 
    530                 535                 540                 

Glu Glu Trp Ser Asp Gln Tyr Gly Tyr His Phe Ser Ile Tyr Ser Thr 
545                 550                 555                 560 

Pro Ser Glu Ser Leu Thr Asp Arg Phe Cys Arg Leu Asp Ile Asp Lys 
                565                 570                 575     

Phe Gly Ser Ile Pro Asp Ile Thr Asp Lys Glu Tyr Tyr Thr Asn Ser 
            580                 585                 590         

Phe His Tyr Asp Val Arg Lys Asn Pro Thr Pro Phe Glu Lys Leu Asp 
        595                 600                 605             

Phe Glu Lys Val Tyr Pro Glu Ala Gly Ala Ser Gly Gly Phe Ile His 
    610                 615                 620                 

Tyr Cys Glu Tyr Pro Val Leu Gln Gln Asn Pro Lys Ala Leu Glu Ala 
625                 630                 635                 640 

Val Trp Asp Tyr Ala Tyr Asp Arg Val Gly Tyr Leu Gly Thr Asn Thr 
                645                 650                 655     

Pro Ile Asp Arg Cys Tyr Lys Cys Asp Phe Glu Gly Asp Phe Glu Pro 
            660                 665                 670         

Thr Glu Arg Gly Phe Ala Cys Pro Asn Cys Gly Asn Ser Asp Pro Lys 
        675                 680                 685             

Thr Val Asp Val Val Lys Arg Thr Cys Gly Tyr Leu Gly Asn Pro Gln 
    690                 695                 700                 

Ala Arg Pro Met Val Asn Gly Arg His Lys Glu Ile Ala Ala Arg Val 
705                 710                 715                 720 

Lys His Met Asn Gly Ser Thr Ile Lys Ile Ala Gly His Gln Val Thr 
                725                 730                 735     

Asn 
    

<210>   219
<211>   138
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   219
atgggaaaat atcaactaga cgataagggg cgcgcacaag tgacccgtta tcacgagaaa   60
cactctaaag gtggagctgg taagaaagaa cgcttgctta gcttcagaga acaattttta   120
aacaagaaca agaaaaaa                                                 138

<210>   220
<211>   46
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   220
Met Gly Lys Tyr Gln Leu Asp Asp Lys Gly Arg Ala Gln Val Thr Arg 
1               5                   10                  15      

Tyr His Glu Lys His Ser Lys Gly Gly Ala Gly Lys Lys Glu Arg Leu 
            20                  25                  30          

Leu Ser Phe Arg Glu Gln Phe Leu Asn Lys Asn Lys Lys Lys 
        35                  40                  45      

<210>   221
<211>   504
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   221
atggaattac gcagaccaag attagcggat aagaaagctg ttttagatat gatgacagag   60
tttgaaaaat ttcagtcgcc tcacgacggc ggtttctggg atacagagaa ctttgtgtat   120
gaagactggt tagaaagcaa tcaggaacag gaaatgggga ttaatctgcc tgaaggatgg   180
gtttctgcaa ttcagttagt ggctttttct gagaaaggtc aagcagttgg atttcttaat   240
ctccggttgc gcctcagtaa ctttctacta gaagaaggtg gccacattgg ctactccatt   300
cgtccatctg aaagaggcaa gggttatgca aaagagactc tccgtcaggg cttgcaagtt   360
gctaaggaaa agaacatcaa gaaagctctg gtgacctgta gtgtgaataa tcctgctagc   420
agagcagtca ttctagcaaa tggtggaata tttgaggatg ctcgcaatgg agtcgagcgt   480
tattggatag aggtagcgaa tgaa                                          504

<210>   222
<211>   168
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902228 (3.E-95)

<400>   222
Met Glu Leu Arg Arg Pro Arg Leu Ala Asp Lys Lys Ala Val Leu Asp 
1               5                   10                  15      

Met Met Thr Glu Phe Glu Lys Phe Gln Ser Pro His Asp Gly Gly Phe 
            20                  25                  30          

Trp Asp Thr Glu Asn Phe Val Tyr Glu Asp Trp Leu Glu Ser Asn Gln 
        35                  40                  45              

Glu Gln Glu Met Gly Ile Asn Leu Pro Glu Gly Trp Val Ser Ala Ile 
    50                  55                  60                  

Gln Leu Val Ala Phe Ser Glu Lys Gly Gln Ala Val Gly Phe Leu Asn 
65                  70                  75                  80  

Leu Arg Leu Arg Leu Ser Asn Phe Leu Leu Glu Glu Gly Gly His Ile 
                85                  90                  95      

Gly Tyr Ser Ile Arg Pro Ser Glu Arg Gly Lys Gly Tyr Ala Lys Glu 
            100                 105                 110         

Thr Leu Arg Gln Gly Leu Gln Val Ala Lys Glu Lys Asn Ile Lys Lys 
        115                 120                 125             

Ala Leu Val Thr Cys Ser Val Asn Asn Pro Ala Ser Arg Ala Val Ile 
    130                 135                 140                 

Leu Ala Asn Gly Gly Ile Phe Glu Asp Ala Arg Asn Gly Val Glu Arg 
145                 150                 155                 160 

Tyr Trp Ile Glu Val Ala Asn Glu 
                165             

<210>   223
<211>   588
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   223
atgaataatc caaaaccaca agaatggaaa agcgaggaac ttagtcaagg tcgtatcatt   60
gactacaagg cctttaactt tgtggacggc gaaggcgtgc gcaactctct ctatgtatca   120
ggctgtatgt ttcactgcga gggatgttat aatgttgcga cttggtcttt taatgctggc   180
attccctata cagcagaatt agaagagcag attatggcag accttgccca accctatgtt   240
caaggcttga ctttgctggg aggggagcct tttctcaata ctgggattct cttgccactt   300
gttaagcgga ttcggaagga attgccagac aaggacatct ggtcctggac cggctacact   360
tgggaagaaa tgatgttgga aactccagat aaactggaat tcttgtcact gattgacatt   420
cttgtcgatg gaagatatga tcgaactaag agaaatctta tgctccagtt tcgaggttca   480
tctaaccaac gaattatcga tgtgcaaaaa tcgctcaaaa gtgggcaagt agtgatttgg   540
gacaagctca atgacggaaa agaaagctat gaacaggtga agagagaa                588

<210>   224
<211>   196
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   anaerobic ribonucleoside-triphosphate reductase activating protein (nrd
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902229 (e-114)

<400>   224
Met Asn Asn Pro Lys Pro Gln Glu Trp Lys Ser Glu Glu Leu Ser Gln 
1               5                   10                  15      

Gly Arg Ile Ile Asp Tyr Lys Ala Phe Asn Phe Val Asp Gly Glu Gly 
            20                  25                  30          

Val Arg Asn Ser Leu Tyr Val Ser Gly Cys Met Phe His Cys Glu Gly 
        35                  40                  45              

Cys Tyr Asn Val Ala Thr Trp Ser Phe Asn Ala Gly Ile Pro Tyr Thr 
    50                  55                  60                  

Ala Glu Leu Glu Glu Gln Ile Met Ala Asp Leu Ala Gln Pro Tyr Val 
65                  70                  75                  80  

Gln Gly Leu Thr Leu Leu Gly Gly Glu Pro Phe Leu Asn Thr Gly Ile 
                85                  90                  95      

Leu Leu Pro Leu Val Lys Arg Ile Arg Lys Glu Leu Pro Asp Lys Asp 
            100                 105                 110         

Ile Trp Ser Trp Thr Gly Tyr Thr Trp Glu Glu Met Met Leu Glu Thr 
        115                 120                 125             

Pro Asp Lys Leu Glu Phe Leu Ser Leu Ile Asp Ile Leu Val Asp Gly 
    130                 135                 140                 

Arg Tyr Asp Arg Thr Lys Arg Asn Leu Met Leu Gln Phe Arg Gly Ser 
145                 150                 155                 160 

Ser Asn Gln Arg Ile Ile Asp Val Gln Lys Ser Leu Lys Ser Gly Gln 
                165                 170                 175     

Val Val Ile Trp Asp Lys Leu Asn Asp Gly Lys Glu Ser Tyr Glu Gln 
            180                 185                 190         

Val Lys Arg Glu 
        195     

<210>   225
<211>   300
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   225
atgaagaaaa aggacttagt agaccaacta gtctcagaga tcgagacggg gaaagtcagg   60
acactgggaa tatacggtca tggagcttca ggtaaatcaa cctttgcaca ggaattgtac   120
caagctttag attctactac agtaaatttg ctagagacag atccttatat cacctcagga   180
cgccatctgg tagtacccaa ggacgcgccg aatcaaaagg tgacagccag tctgccagtg   240
gcgcatgaac tggagagttt gcagagagat atccttgctt gcaggcgggt atggatgtct   300

<210>   226
<211>   100
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902230 (2.E-48)

<400>   226
Met Lys Lys Lys Asp Leu Val Asp Gln Leu Val Ser Glu Ile Glu Thr 
1               5                   10                  15      

Gly Lys Val Arg Thr Leu Gly Ile Tyr Gly His Gly Ala Ser Gly Lys 
            20                  25                  30          

Ser Thr Phe Ala Gln Glu Leu Tyr Gln Ala Leu Asp Ser Thr Thr Val 
        35                  40                  45              

Asn Leu Leu Glu Thr Asp Pro Tyr Ile Thr Ser Gly Arg His Leu Val 
    50                  55                  60                  

Val Pro Lys Asp Ala Pro Asn Gln Lys Val Thr Ala Ser Leu Pro Val 
65                  70                  75                  80  

Ala His Glu Leu Glu Ser Leu Gln Arg Asp Ile Leu Ala Cys Arg Arg 
                85                  90                  95      

Val Trp Met Ser 
            100 

<210>   227
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   227
ttgcaggcgg gtatggatgt cttgacaatt gaagaacctt ggaaggctag tgaggtcttg   60
tctggagcca aaccaatttt gattgtcgaa gggatgtctg ttggctttct acccaaggaa   120
ctctttgaaa aaaccatctg tttctacacg gatgaggaga ccgaattaaa gcgacgcctt   180
gctagagata cgactgtgag aaatcgcgat gcatccttta tattggctag ccatcagatg   240
agacgggagc agtatctgcg atactataaa gaaactgagt ctaaggcgga tatcttagtg   300
gaccaatcag aagataaatt tgatgtcaag aggact                             336

<210>   228
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902230 (5.E-60)

<400>   228
Met Gln Ala Gly Met Asp Val Leu Thr Ile Glu Glu Pro Trp Lys Ala 
1               5                   10                  15      

Ser Glu Val Leu Ser Gly Ala Lys Pro Ile Leu Ile Val Glu Gly Met 
            20                  25                  30          

Ser Val Gly Phe Leu Pro Lys Glu Leu Phe Glu Lys Thr Ile Cys Phe 
        35                  40                  45              

Tyr Thr Asp Glu Glu Thr Glu Leu Lys Arg Arg Leu Ala Arg Asp Thr 
    50                  55                  60                  

Thr Val Arg Asn Arg Asp Ala Ser Phe Ile Leu Ala Ser His Gln Met 
65                  70                  75                  80  

Arg Arg Glu Gln Tyr Leu Arg Tyr Tyr Lys Glu Thr Glu Ser Lys Ala 
                85                  90                  95      

Asp Ile Leu Val Asp Gln Ser Glu Asp Lys Phe Asp Val Lys Arg Thr 
            100                 105                 110         


<210>   229
<211>   306
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   229
atggcaaaca aaaaaatccg tatccgtttg aaagcttacg aacaccgtac gcttgacaca   60
gcggctgcaa aaatcgtaga atcagctact cgtacaggtg cacaagttgc gggtccaatc   120
ccacttccaa ctgaacgtag cctctacaca atcattcgtg cgactcacaa atacaaagac   180
tctcgcgaac aatttgaaat gcgtacacac aaacgtttga tcgatatcgt taacccaact   240
caaaaaacag ttgatgcctt gatgaaattg gatcttccaa gtggtgtaaa cgtagaaatc   300
aaactt                                                              306

<210>   230
<211>   102
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S10 (rpsJ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902231 (1.E-53)

<400>   230
Met Ala Asn Lys Lys Ile Arg Ile Arg Leu Lys Ala Tyr Glu His Arg 
1               5                   10                  15      

Thr Leu Asp Thr Ala Ala Ala Lys Ile Val Glu Ser Ala Thr Arg Thr 
            20                  25                  30          

Gly Ala Gln Val Ala Gly Pro Ile Pro Leu Pro Thr Glu Arg Ser Leu 
        35                  40                  45              

Tyr Thr Ile Ile Arg Ala Thr His Lys Tyr Lys Asp Ser Arg Glu Gln 
    50                  55                  60                  

Phe Glu Met Arg Thr His Lys Arg Leu Ile Asp Ile Val Asn Pro Thr 
65                  70                  75                  80  

Gln Lys Thr Val Asp Ala Leu Met Lys Leu Asp Leu Pro Ser Gly Val 
                85                  90                  95      

Asn Val Glu Ile Lys Leu 
            100         

<210>   231
<211>   624
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   231
atgacaaaag gaatcttagg gaaaaaagtg ggaatgactc aaatcttcac tgaagctggc   60
gaattgatcc ctgtaacagt tattgaagca actccaaacg ttgttcttca agttaaaact   120
gttgaaacag acggatacaa cgctatccaa gttggtttcg atgacaaacg cgaagtattg   180
agcaacaaac ctgctaaagg acatgtagcg aaagctaaca cggctcctaa gcgcttcatt   240
cgtgaattca aaaacgttga aggcttggaa gttggtgctg aaattacagt tgaaacattc   300
gcagctggag acgttgttga cgtaacgggt acttctaaag gtaaaggttt ccaaggtgtt   360
atcaaacgcc acggacaatc acgtggacca atggctcacg gttctcgtta ccaccgtcgt   420
ccaggttcta tggggcctgt tgcacctaac cgcgtattca aaggtaaaaa ccttgcagga   480
cgtatgggtg gcgaccgcgt aacaattcaa aaccttgaag ttgtacaagt tgttccagaa   540
aagaacgtta tccttatcaa aggtaacgta ccaggtgcta agaaatctct tatcactatc   600
aaatcagcag ttaaagctgg taaa                                          624

<210>   232
<211>   208
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L3 (rplC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902232 (e-116)

<400>   232
Met Thr Lys Gly Ile Leu Gly Lys Lys Val Gly Met Thr Gln Ile Phe 
1               5                   10                  15      

Thr Glu Ala Gly Glu Leu Ile Pro Val Thr Val Ile Glu Ala Thr Pro 
            20                  25                  30          

Asn Val Val Leu Gln Val Lys Thr Val Glu Thr Asp Gly Tyr Asn Ala 
        35                  40                  45              

Ile Gln Val Gly Phe Asp Asp Lys Arg Glu Val Leu Ser Asn Lys Pro 
    50                  55                  60                  

Ala Lys Gly His Val Ala Lys Ala Asn Thr Ala Pro Lys Arg Phe Ile 
65                  70                  75                  80  

Arg Glu Phe Lys Asn Val Glu Gly Leu Glu Val Gly Ala Glu Ile Thr 
                85                  90                  95      

Val Glu Thr Phe Ala Ala Gly Asp Val Val Asp Val Thr Gly Thr Ser 
            100                 105                 110         

Lys Gly Lys Gly Phe Gln Gly Val Ile Lys Arg His Gly Gln Ser Arg 
        115                 120                 125             

Gly Pro Met Ala His Gly Ser Arg Tyr His Arg Arg Pro Gly Ser Met 
    130                 135                 140                 

Gly Pro Val Ala Pro Asn Arg Val Phe Lys Gly Lys Asn Leu Ala Gly 
145                 150                 155                 160 

Arg Met Gly Gly Asp Arg Val Thr Ile Gln Asn Leu Glu Val Val Gln 
                165                 170                 175     

Val Val Pro Glu Lys Asn Val Ile Leu Ile Lys Gly Asn Val Pro Gly 
            180                 185                 190         

Ala Lys Lys Ser Leu Ile Thr Ile Lys Ser Ala Val Lys Ala Gly Lys 
        195                 200                 205             


<210>   233
<211>   621
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   233
atggcaaacg taacattatt tgaccaaact ggtaaagaag ctggccaagt tgttcttagc   60
gatgcagtat ttggtatcga accaaatgaa tcagttgtgt ttgatgtaat catcagccaa   120
cgcgcaagcc ttcgtcaagg aacacacgct gttaaaaacc gctctgcagt atcaggtggt   180
ggacgcaaac catggcgtca aaaaggaact ggacgtgctc gtcaaggttc tatccgctca   240
ccacaatggc gtggtggtgg tgttgtcttc ggaccaactc cacgttcata cggctacaaa   300
cttccacaaa aagttcgtcg cctagctctt aaatcagttt actctgaaaa agttgctgaa   360
aacaaattcg tagctgtaga cgctctttca tttacagctc caaaaactgc tgaatttgca   420
aaagttcttg cagcattgag catcgattct aaagttcttg ttatccttga agaaggaaat   480
gaattcgcag ctctttcagc tcgtaacctt ccaaacgtga aagttgcaac tgctacaact   540
gcaagtgttc ttgacatcgc aaatagcgac aaacttcttg tcacacaagc agctatctct   600
aaaatcgagg aggttcttgc a                                             621

<210>   234
<211>   207
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L4 (rplD)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902233 (e-112)

<400>   234
Met Ala Asn Val Thr Leu Phe Asp Gln Thr Gly Lys Glu Ala Gly Gln 
1               5                   10                  15      

Val Val Leu Ser Asp Ala Val Phe Gly Ile Glu Pro Asn Glu Ser Val 
            20                  25                  30          

Val Phe Asp Val Ile Ile Ser Gln Arg Ala Ser Leu Arg Gln Gly Thr 
        35                  40                  45              

His Ala Val Lys Asn Arg Ser Ala Val Ser Gly Gly Gly Arg Lys Pro 
    50                  55                  60                  

Trp Arg Gln Lys Gly Thr Gly Arg Ala Arg Gln Gly Ser Ile Arg Ser 

65                  70                  75                  80  

Pro Gln Trp Arg Gly Gly Gly Val Val Phe Gly Pro Thr Pro Arg Ser 
                85                  90                  95      

Tyr Gly Tyr Lys Leu Pro Gln Lys Val Arg Arg Leu Ala Leu Lys Ser 
            100                 105                 110         

Val Tyr Ser Glu Lys Val Ala Glu Asn Lys Phe Val Ala Val Asp Ala 
        115                 120                 125             

Leu Ser Phe Thr Ala Pro Lys Thr Ala Glu Phe Ala Lys Val Leu Ala 
    130                 135                 140                 

Ala Leu Ser Ile Asp Ser Lys Val Leu Val Ile Leu Glu Glu Gly Asn 
145                 150                 155                 160 

Glu Phe Ala Ala Leu Ser Ala Arg Asn Leu Pro Asn Val Lys Val Ala 
                165                 170                 175     

Thr Ala Thr Thr Ala Ser Val Leu Asp Ile Ala Asn Ser Asp Lys Leu 
            180                 185                 190         

Leu Val Thr Gln Ala Ala Ile Ser Lys Ile Glu Glu Val Leu Ala 
        195                 200                 205         

<210>   235
<211>   294
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   235
atgaatttgt atgatgttat caaaaaacct gtcatcactg aaagctcaat ggctcaactt   60
gaagcaggaa aatatgtatt tgaagttgac actcgtgcac acaaactttt gatcaagcaa   120
gctgttgaag ctgctttcga aggtgttaaa gttgccaatg ttaacacaat caacgtaaaa   180
ccaaaagcta aacgtgttgg acgttacact ggttttacta acaaaactaa aaaagctatc   240
atcacactta cagctgattc taaagcaatc gagttgtttg ctgctgaagc tgaa         294

<210>   236
<211>   98
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L23 (rplW)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902234 (3.E-50)

<400>   236
Met Asn Leu Tyr Asp Val Ile Lys Lys Pro Val Ile Thr Glu Ser Ser 
1               5                   10                  15      

Met Ala Gln Leu Glu Ala Gly Lys Tyr Val Phe Glu Val Asp Thr Arg 
            20                  25                  30          

Ala His Lys Leu Leu Ile Lys Gln Ala Val Glu Ala Ala Phe Glu Gly 
        35                  40                  45              

Val Lys Val Ala Asn Val Asn Thr Ile Asn Val Lys Pro Lys Ala Lys 
    50                  55                  60                  

Arg Val Gly Arg Tyr Thr Gly Phe Thr Asn Lys Thr Lys Lys Ala Ile 
65                  70                  75                  80  

Ile Thr Leu Thr Ala Asp Ser Lys Ala Ile Glu Leu Phe Ala Ala Glu 
                85                  90                  95      

Ala Glu 
        

<210>   237
<211>   831
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   237
gtgggaattc gtgtttataa accaacaaca aacggtcgcc gtaatatgac ttctttggat   60
ttcgctgaaa tcacaacaag cactcctgaa aaatcattgc ttgttgcatt gaagagcaag   120
gctggtcgta acaacaacgg tcgtatcaca gttcgtcacc aaggtggtgg acacaaacgt   180
ttctaccgtt tggttgactt caaacgtaat aaagacaacg ttgaagcagt tgttaaaaca   240
atcgagtacg atccaaaccg ttctgcaaac atcgctcttg tacactacac tgacggtgtg   300
aaagcataca tcatcgctcc aaaaggtctt gaagtaggtc aacgtatcgt ttcaggtcca   360
gaagcagata tcaaagtcgg aaacgctctt ccacttgcta acatcccagt tggtactttg   420
attcacaaca tcgagttgaa accaggtcgt ggtggtgaat tggtacgtgc tgctggtgca   480
tctgctcaag tattgggttc tgaaggtaaa tatgttcttg ttcgtcttca atcaggtgaa   540
gttcgtatga ttcttggaac ttgccgtgct acagttggtg ttgtcggaaa cgaacaacat   600
ggacttgtaa accttggtaa agcaggacgt agccgttgga aaggtatccg cccaacagtt   660
cgtggttctg taatgaaccc taacgatcac ccacacggtg gtggtgaagg taaagcacca   720
gttggtcgta aagcaccatc tactccatgg ggcaaacctg ctcttggtct taaaactcgt   780
aacaagaaag cgaaatctga caaacttatc gttcgtcgtc gcaacgagaa a            831

<210>   238
<211>   277
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L2 (rplB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902235 (e-160)

<400>   238
Met Gly Ile Arg Val Tyr Lys Pro Thr Thr Asn Gly Arg Arg Asn Met 
1               5                   10                  15      

Thr Ser Leu Asp Phe Ala Glu Ile Thr Thr Ser Thr Pro Glu Lys Ser 
            20                  25                  30          

Leu Leu Val Ala Leu Lys Ser Lys Ala Gly Arg Asn Asn Asn Gly Arg 
        35                  40                  45              

Ile Thr Val Arg His Gln Gly Gly Gly His Lys Arg Phe Tyr Arg Leu 
    50                  55                  60                  

Val Asp Phe Lys Arg Asn Lys Asp Asn Val Glu Ala Val Val Lys Thr 
65                  70                  75                  80  

Ile Glu Tyr Asp Pro Asn Arg Ser Ala Asn Ile Ala Leu Val His Tyr 
                85                  90                  95      

Thr Asp Gly Val Lys Ala Tyr Ile Ile Ala Pro Lys Gly Leu Glu Val 
            100                 105                 110         

Gly Gln Arg Ile Val Ser Gly Pro Glu Ala Asp Ile Lys Val Gly Asn 
        115                 120                 125             

Ala Leu Pro Leu Ala Asn Ile Pro Val Gly Thr Leu Ile His Asn Ile 
    130                 135                 140                 

Glu Leu Lys Pro Gly Arg Gly Gly Glu Leu Val Arg Ala Ala Gly Ala 
145                 150                 155                 160 

Ser Ala Gln Val Leu Gly Ser Glu Gly Lys Tyr Val Leu Val Arg Leu 
                165                 170                 175     

Gln Ser Gly Glu Val Arg Met Ile Leu Gly Thr Cys Arg Ala Thr Val 
            180                 185                 190         

Gly Val Val Gly Asn Glu Gln His Gly Leu Val Asn Leu Gly Lys Ala 
        195                 200                 205             

Gly Arg Ser Arg Trp Lys Gly Ile Arg Pro Thr Val Arg Gly Ser Val 
    210                 215                 220                 

Met Asn Pro Asn Asp His Pro His Gly Gly Gly Glu Gly Lys Ala Pro 
225                 230                 235                 240 

Val Gly Arg Lys Ala Pro Ser Thr Pro Trp Gly Lys Pro Ala Leu Gly 
                245                 250                 255     

Leu Lys Thr Arg Asn Lys Lys Ala Lys Ser Asp Lys Leu Ile Val Arg 
            260                 265                 270         

Arg Arg Asn Glu Lys 
        275         

<210>   239
<211>   279
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   239
atgggacgca gtcttaaaaa aggacctttc gtcgatgagc atttgatgaa aaaagttgaa   60
gctcaagcta acgacgaaaa gaaaaaagtt attaaaactt ggtcacgtcg ttcaacgatc   120
ttcccaagtt tcattggtta cactattgca gtttatgacg gacgtaaaca cgtacctgtt   180
tacatccaag aagacatggt aggccacaaa cttggtgaat ttgcaccaac tcgtacttac   240
aaaggtcacg ctgcagacga caagaaaaca cgtagaaaa                          279

<210>   240
<211>   93
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S19 (rpsS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902236 (1.E-51)

<400>   240
Met Gly Arg Ser Leu Lys Lys Gly Pro Phe Val Asp Glu His Leu Met 
1               5                   10                  15      

Lys Lys Val Glu Ala Gln Ala Asn Asp Glu Lys Lys Lys Val Ile Lys 
            20                  25                  30          

Thr Trp Ser Arg Arg Ser Thr Ile Phe Pro Ser Phe Ile Gly Tyr Thr 
        35                  40                  45              

Ile Ala Val Tyr Asp Gly Arg Lys His Val Pro Val Tyr Ile Gln Glu 
    50                  55                  60                  

Asp Met Val Gly His Lys Leu Gly Glu Phe Ala Pro Thr Arg Thr Tyr 
65                  70                  75                  80  

Lys Gly His Ala Ala Asp Asp Lys Lys Thr Arg Arg Lys 
                85                  90              

<210>   241
<211>   342
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   241
atggcagaaa ttacttcagc taaagcaatg gctcgtacag tacgtgtttc acctcgtaaa   60
tcacgtcttg ttcttgataa catccgtggt aaaagcgtag ccgatgcaat cgcaatcttg   120
acattcactc caaacaaagc tgctgaaatc atcttgaaag ttttgaactc agctgtagct   180
aacgctgaaa acaactttgg tttggataaa gctaacttgg tagtatctga agcattcgca   240
aacgaaggac caactatgaa acgtttccgt ccacgtgcga aaggttcagc ttcaccaatc   300
aacaaacgta cagctcacat cactgtagct gttgcagaaa aa                      342

<210>   242
<211>   114
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L22 (rplV)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902238 (2.E-58)

<400>   242
Met Ala Glu Ile Thr Ser Ala Lys Ala Met Ala Arg Thr Val Arg Val 
1               5                   10                  15      

Ser Pro Arg Lys Ser Arg Leu Val Leu Asp Asn Ile Arg Gly Lys Ser 
            20                  25                  30          

Val Ala Asp Ala Ile Ala Ile Leu Thr Phe Thr Pro Asn Lys Ala Ala 
        35                  40                  45              

Glu Ile Ile Leu Lys Val Leu Asn Ser Ala Val Ala Asn Ala Glu Asn 
    50                  55                  60                  

Asn Phe Gly Leu Asp Lys Ala Asn Leu Val Val Ser Glu Ala Phe Ala 
65                  70                  75                  80  

Asn Glu Gly Pro Thr Met Lys Arg Phe Arg Pro Arg Ala Lys Gly Ser 
                85                  90                  95      

Ala Ser Pro Ile Asn Lys Arg Thr Ala His Ile Thr Val Ala Val Ala 
            100                 105                 110         

Glu Lys 
        

<210>   243
<211>   651
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   243
gtgggtcaaa aagtacatcc aattggtatg cgtgtcggca tcatccgtga ttgggatgcc   60
aaatggtatg ctgaaaaaga atacgcggat taccttcatg aagatcttgc aatccgtaaa   120
ttcgttcaaa aagaacttgc tgacgcagca gtttcaacta ttgaaatcga acgcgcagta   180
aacaaagtta acgtttcact tcacactgct aaaccaggta tggttatcgg taaaggtggt   240
gctaacgttg atgcactccg tgcaaaactt aacaaattga ctggaaaaca agtacacatc   300
aacatcatcg aaatcaaaca acctgatttg gatgctcacc ttgtaggtga aggaattgct   360
cgtcaattgg agcaacgtgt tgctttccgt cgtgcacaaa aacaagcaat ccaacgtgca   420
atgcgtgctg gagctaaagg aatcaaaact caagtatcag gtcgtttgaa cggtgcagat   480
atcgcccgtg ctgaaggata ctctgaagga actgttccgc ttcacacact tcgtgcagat   540
atcgattacg cttgggaaga agcagatact acatacggta aacttggtgt taaagtatgg   600
atctaccgtg gtgaagttct tccagctcgt aaaaacacta aaggaggtaa a            651

<210>   244
<211>   217
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S3 (rpsC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902239 (e-123)

<400>   244
Met Gly Gln Lys Val His Pro Ile Gly Met Arg Val Gly Ile Ile Arg 
1               5                   10                  15      

Asp Trp Asp Ala Lys Trp Tyr Ala Glu Lys Glu Tyr Ala Asp Tyr Leu 
            20                  25                  30          

His Glu Asp Leu Ala Ile Arg Lys Phe Val Gln Lys Glu Leu Ala Asp 
        35                  40                  45              

Ala Ala Val Ser Thr Ile Glu Ile Glu Arg Ala Val Asn Lys Val Asn 
    50                  55                  60                  

Val Ser Leu His Thr Ala Lys Pro Gly Met Val Ile Gly Lys Gly Gly 
65                  70                  75                  80  

Ala Asn Val Asp Ala Leu Arg Ala Lys Leu Asn Lys Leu Thr Gly Lys 
                85                  90                  95      

Gln Val His Ile Asn Ile Ile Glu Ile Lys Gln Pro Asp Leu Asp Ala 
            100                 105                 110         

His Leu Val Gly Glu Gly Ile Ala Arg Gln Leu Glu Gln Arg Val Ala 
        115                 120                 125             

Phe Arg Arg Ala Gln Lys Gln Ala Ile Gln Arg Ala Met Arg Ala Gly 
    130                 135                 140                 

Ala Lys Gly Ile Lys Thr Gln Val Ser Gly Arg Leu Asn Gly Ala Asp 
145                 150                 155                 160 

Ile Ala Arg Ala Glu Gly Tyr Ser Glu Gly Thr Val Pro Leu His Thr 
                165                 170                 175     

Leu Arg Ala Asp Ile Asp Tyr Ala Trp Glu Glu Ala Asp Thr Thr Tyr 
            180                 185                 190         

Gly Lys Leu Gly Val Lys Val Trp Ile Tyr Arg Gly Glu Val Leu Pro 
        195                 200                 205             

Ala Arg Lys Asn Thr Lys Gly Gly Lys 
    210                 215         

<210>   245
<211>   411
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   245
atgttagtac ctaaacgtgt taaacaccgt cgtgagttcc gtggaaaaat gcgcggtgaa   60
gcaaaaggtg gaaaagaagt agcattcggt gaatacggtc ttcaagctac aactagccac   120
tggatcacta accgccaaat cgaagctgct cgtatcgcca tgactcgtta catgaaacgt   180
ggtggtaaag tttggattaa aatcttccca cacaaatcat acactgctaa agctatcggt   240
gtgcgtatgg gatctggtaa aggggcacct gaaggttggg tagcaccagt taaacgtggt   300
aaagtgatgt tcgaaatcgc tggtgtatct gaagagattg cacgtgaagc gcttcgactt   360
gctagccaca aattgccagt taaatgtaaa ttcgtaaaac gtgaagcaga a            411

<210>   246
<211>   137
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L16 (rplP)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902240 (6.E-77)

<400>   246
Met Leu Val Pro Lys Arg Val Lys His Arg Arg Glu Phe Arg Gly Lys 
1               5                   10                  15      

Met Arg Gly Glu Ala Lys Gly Gly Lys Glu Val Ala Phe Gly Glu Tyr 
            20                  25                  30          

Gly Leu Gln Ala Thr Thr Ser His Trp Ile Thr Asn Arg Gln Ile Glu 
        35                  40                  45              

Ala Ala Arg Ile Ala Met Thr Arg Tyr Met Lys Arg Gly Gly Lys Val 
    50                  55                  60                  

Trp Ile Lys Ile Phe Pro His Lys Ser Tyr Thr Ala Lys Ala Ile Gly 
65                  70                  75                  80  

Val Arg Met Gly Ser Gly Lys Gly Ala Pro Glu Gly Trp Val Ala Pro 
                85                  90                  95      

Val Lys Arg Gly Lys Val Met Phe Glu Ile Ala Gly Val Ser Glu Glu 
            100                 105                 110         

Ile Ala Arg Glu Ala Leu Arg Leu Ala Ser His Lys Leu Pro Val Lys 
        115                 120                 125             

Cys Lys Phe Val Lys Arg Glu Ala Glu 
    130                 135         

<210>   247
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   247
atgaaactta atgaagtaaa agaatttgtt aaagaacttc gtggtctttc tcaagaagaa   60
ctcgcgaagc gcgaaaacga attgaaaaaa gaattgtttg aacttcgttt ccaagctgct   120
actggtcaat tggaacaaac agctcgcttg aaagaagtta aaaaacaaat cgctcgcatc   180
aaaacagttc aatctgaagc gaaa                                          204

<210>   248
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L29 (rpmC)

<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902241 (1.E-32)

<400>   248
Met Lys Leu Asn Glu Val Lys Glu Phe Val Lys Glu Leu Arg Gly Leu 
1               5                   10                  15      

Ser Gln Glu Glu Leu Ala Lys Arg Glu Asn Glu Leu Lys Lys Glu Leu 
            20                  25                  30          

Phe Glu Leu Arg Phe Gln Ala Ala Thr Gly Gln Leu Glu Gln Thr Ala 
        35                  40                  45              

Arg Leu Lys Glu Val Lys Lys Gln Ile Ala Arg Ile Lys Thr Val Gln 
    50                  55                  60                  

Ser Glu Ala Lys 
65              

<210>   249
<211>   396
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   249
ttgaactgtt ttgatgcgag cgatttgttt tttaacttct ttcaagcgag ctgtttgttc   60
caattgacca gtagcagctt ggaaacgaag ttcaaacaat tcttttttca attcgttttc   120
gcgcttcgcg agttcttctt gagaaagacc acgaagttct ttaacaaatt cttttacttc   180
attaagtttc atgccttctc cttattctgc ttcacgtttt acgaatttac atttaactgg   240
caatttgtgg ctagcaagtc gaagcgcttc acgtgcaatc tcttcagata caccagcgat   300
ttcgaacatc actttaccac gtttaactgg tgctacccaa ccttcaggtg cccctttacc   360
agatcccata cgcacaccga tagctttagc agtgta                             396

<210>   250
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   250
Met Asn Cys Phe Asp Ala Ser Asp Leu Phe Phe Asn Phe Phe Gln Ala 
1               5                   10                  15      

Ser Cys Leu Phe Gln Leu Thr Ser Ser Ser Leu Glu Thr Lys Phe Lys 
            20                  25                  30          

Gln Phe Phe Phe Gln Phe Val Phe Ala Leu Arg Glu Phe Phe Leu Arg 
        35                  40                  45              

Lys Thr Thr Lys Phe Phe Asn Lys Phe Phe Tyr Phe Ile Lys Phe His 
    50                  55                  60                  

Ala Phe Ser Leu Phe Cys Phe Thr Phe Tyr Glu Phe Thr Phe Asn Trp 
65                  70                  75                  80  

Gln Phe Val Ala Ser Lys Ser Lys Arg Phe Thr Cys Asn Leu Phe Arg 
                85                  90                  95      

Tyr Thr Ser Asp Phe Glu His His Phe Thr Thr Phe Asn Trp Cys Tyr 
            100                 105                 110         

Pro Thr Phe Arg Cys Pro Phe Thr Arg Ser His Thr His Thr Asp Ser 
        115                 120                 125             

Phe Ser Ser Val 
    130         

<210>   251
<211>   258
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   251
atggaacgca ataatcgtaa agttcttgtt ggacgtgttg tatctgacaa aatggacaag   60
acaatcacag ttgtagttga aacaaaacgt aaccacccag tctatggtaa acgtattaac   120
tactctaaaa aatacaaagc tcatgatgaa aacaatgttg ccaaagaagg cgatatcgta   180
cgtatcatgg aaactcgccc gctttcagct acaaaacgtt tccgtcttgt agaagttgtt   240
gaagaagcgg tcatcatc                                                 258

<210>   252
<211>   86
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S17 (rpsQ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902242 (1.E-44)

<400>   252
Met Glu Arg Asn Asn Arg Lys Val Leu Val Gly Arg Val Val Ser Asp 
1               5                   10                  15      

Lys Met Asp Lys Thr Ile Thr Val Val Val Glu Thr Lys Arg Asn His 
            20                  25                  30          

Pro Val Tyr Gly Lys Arg Ile Asn Tyr Ser Lys Lys Tyr Lys Ala His 
        35                  40                  45              

Asp Glu Asn Asn Val Ala Lys Glu Gly Asp Ile Val Arg Ile Met Glu 
    50                  55                  60                  

Thr Arg Pro Leu Ser Ala Thr Lys Arg Phe Arg Leu Val Glu Val Val 
65                  70                  75                  80  

Glu Glu Ala Val Ile Ile 
                85      

<210>   253
<211>   366
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   253
atgattcaaa cagaaactcg tttgaaagtc gcagacaaca gcggtgctcg cgaaatcttg   60
actatcaaag ttcttggtgg ttcaggacgt aaatttgcaa acatcggtga tgttatcgtg   120
gcatctgtaa aacaagctac tcctggtggt gcggttaaaa aaggtgacgt tgttaaagca   180
gttatcgttc gtactaaatc aggtgctcgt cgtgctgatg gttcatacat caaatttgac   240
gaaaacgcag cagttatcat ccgtgaagac aaaactcctc gcggaacacg tatctttggc   300
ccagttgcac gtgaattgcg tgaaggtggc ttcatgaaga tcgtgtcact tgctccagaa   360
gtactt                                                              366

<210>   254
<211>   122
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L14 (rplN)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902243 (1.E-63)

<400>   254
Met Ile Gln Thr Glu Thr Arg Leu Lys Val Ala Asp Asn Ser Gly Ala 
1               5                   10                  15      

Arg Glu Ile Leu Thr Ile Lys Val Leu Gly Gly Ser Gly Arg Lys Phe 
            20                  25                  30          

Ala Asn Ile Gly Asp Val Ile Val Ala Ser Val Lys Gln Ala Thr Pro 
        35                  40                  45              

Gly Gly Ala Val Lys Lys Gly Asp Val Val Lys Ala Val Ile Val Arg 
    50                  55                  60                  

Thr Lys Ser Gly Ala Arg Arg Ala Asp Gly Ser Tyr Ile Lys Phe Asp 
65                  70                  75                  80  

Glu Asn Ala Ala Val Ile Ile Arg Glu Asp Lys Thr Pro Arg Gly Thr 
                85                  90                  95      

Arg Ile Phe Gly Pro Val Ala Arg Glu Leu Arg Glu Gly Gly Phe Met 
            100                 105                 110         

Lys Ile Val Ser Leu Ala Pro Glu Val Leu 
        115                 120         

<210>   255
<211>   303
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   255
atgtttgtaa aaaaaggcga caaagttcgc gtaatcgctg gtaaagataa gggaacagaa   60
gctgttgtcc ttactgccct tccaaaagta aacaaagtta tcgttgaagg tgttaacatt   120
gttaagaaac accaacgtcc aactaacgag cttcctcaag gtggtatcat cgagaaagaa   180
gcagctatcc acgtatcaaa cgttcaagtt ttggacaaaa atggtgtagc tggtcgtgtt   240
ggatacaaat ttgtagacgg taaaaaagtt cgctacaaca aaaaatcagg cgaagtgctt   300
gat                                                                 303

<210>   256
<211>   101
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L24 (rplX)

<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902244 (2.E-53)

<400>   256
Met Phe Val Lys Lys Gly Asp Lys Val Arg Val Ile Ala Gly Lys Asp 
1               5                   10                  15      

Lys Gly Thr Glu Ala Val Val Leu Thr Ala Leu Pro Lys Val Asn Lys 
            20                  25                  30          

Val Ile Val Glu Gly Val Asn Ile Val Lys Lys His Gln Arg Pro Thr 
        35                  40                  45              

Asn Glu Leu Pro Gln Gly Gly Ile Ile Glu Lys Glu Ala Ala Ile His 
    50                  55                  60                  

Val Ser Asn Val Gln Val Leu Asp Lys Asn Gly Val Ala Gly Arg Val 
65                  70                  75                  80  

Gly Tyr Lys Phe Val Asp Gly Lys Lys Val Arg Tyr Asn Lys Lys Ser 
                85                  90                  95      

Gly Glu Val Leu Asp 
            100     

<210>   257
<211>   540
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   257
atggcaaatc gtttaaaaga aaaatatctt aatgaagtag ttcctgcttt gacagaacaa   60
ttcaactact catcagtgat ggctgtgcct aaagtagata agattgtttt gaacatgggt   120
gttggtgaag ctgtatcaaa cgctaaaagc cttgaaaaag ctgctgaaga attggcactt   180
atctcaggtc aaaaaccact tatcactaaa gctaaaaaat caatcgccgg cttccgtctt   240
cgtgaaggtg ttgcgatcgg tgcaaaagtt acccttcgtg gtgaacgtat gtacgaattc   300
ttggataaat tggtatcagt ttcacttcca cgtgtacgtg acttccacgg tgtcccaaca   360
aaatcatttg atggacgcgg gaactacaca cttggtgtga aagaacaatt aatcttccca   420
gaaatcaact tcgatgacgt tgacaaaact cgtggtcttg acatcgttat cgtaacaact   480

gctaacactg acgaagagtc acgtgcattg cttacaggcc ttggaatgcc ttttgcaaaa   540

<210>   258
<211>   180
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L5 (rplE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902245 (8.E-98)

<400>   258
Met Ala Asn Arg Leu Lys Glu Lys Tyr Leu Asn Glu Val Val Pro Ala 
1               5                   10                  15      

Leu Thr Glu Gln Phe Asn Tyr Ser Ser Val Met Ala Val Pro Lys Val 
            20                  25                  30          

Asp Lys Ile Val Leu Asn Met Gly Val Gly Glu Ala Val Ser Asn Ala 
        35                  40                  45              

Lys Ser Leu Glu Lys Ala Ala Glu Glu Leu Ala Leu Ile Ser Gly Gln 
    50                  55                  60                  

Lys Pro Leu Ile Thr Lys Ala Lys Lys Ser Ile Ala Gly Phe Arg Leu 
65                  70                  75                  80  

Arg Glu Gly Val Ala Ile Gly Ala Lys Val Thr Leu Arg Gly Glu Arg 
                85                  90                  95      

Met Tyr Glu Phe Leu Asp Lys Leu Val Ser Val Ser Leu Pro Arg Val 
            100                 105                 110         

Arg Asp Phe His Gly Val Pro Thr Lys Ser Phe Asp Gly Arg Gly Asn 
        115                 120                 125             

Tyr Thr Leu Gly Val Lys Glu Gln Leu Ile Phe Pro Glu Ile Asn Phe 
    130                 135                 140                 

Asp Asp Val Asp Lys Thr Arg Gly Leu Asp Ile Val Ile Val Thr Thr 
145                 150                 155                 160 

Ala Asn Thr Asp Glu Glu Ser Arg Ala Leu Leu Thr Gly Leu Gly Met 
                165                 170                 175     

Pro Phe Ala Lys 
            180 

<210>   259
<211>   267
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   259
atggctaaaa aatcaatggt agctagagag gctaaacgcc aaaaaattgt tgaccgttat   60
gctgaaaaac gtgctgcatt aaaggcggca ggggactacg aaggtttatc taaattacct   120
cgcaacgcct caccgactcg tttacataat cgttgtaggg ttacggggcg cccacattca   180
gtttaccgca aatttggtct gagtcgtatc gcttttcgcg aacttgcgca taaaggtcaa   240
attcctggtg taacaaaagc atcttgg                                       267

<210>   260
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S14 (rpsN)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902246 (8.E-48)

<400>   260
Met Ala Lys Lys Ser Met Val Ala Arg Glu Ala Lys Arg Gln Lys Ile 
1               5                   10                  15      

Val Asp Arg Tyr Ala Glu Lys Arg Ala Ala Leu Lys Ala Ala Gly Asp 
            20                  25                  30          

Tyr Glu Gly Leu Ser Lys Leu Pro Arg Asn Ala Ser Pro Thr Arg Leu 
        35                  40                  45              

His Asn Arg Cys Arg Val Thr Gly Arg Pro His Ser Val Tyr Arg Lys 
    50                  55                  60                  

Phe Gly Leu Ser Arg Ile Ala Phe Arg Glu Leu Ala His Lys Gly Gln 
65                  70                  75                  80  

Ile Pro Gly Val Thr Lys Ala Ser Trp 
                85                  

<210>   261
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   261
gtgaaaaaga taaactttcc tagaaacttt agtttcttcg tcaagtttcc tatttttact   60
tggagttttg acgctcttga tatcttaaat taccaagatg cttttgttac accaggaatt   120

<210>   262
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   262
Met Lys Lys Ile Asn Phe Pro Arg Asn Phe Ser Phe Phe Val Lys Phe 
1               5                   10                  15      

Pro Ile Phe Thr Trp Ser Phe Asp Ala Leu Asp Ile Leu Asn Tyr Gln 
            20                  25                  30          

Asp Ala Phe Val Thr Pro Gly Ile 
        35                  40  

<210>   263
<211>   396
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   263
atggttatga ctgacccaat cgcagacttc ctaactcgta ttcgtaatgc taaccaagct   60
aaacacgaag tacttgaagt acctgcatca aacatcaaaa aagggattgc tgaaatcctt   120
aaacgcgaag gttttgtaaa aaacgttgaa atcattgaag atgacaaaca aggcgtcatc   180
cgtgtatttc ttaaatacgg accaaatggt gagaaagtta tcactaactt gaaacgtgtt   240
tctaaaccag gacttcgtgt ctacaaaaaa cgtgaagacc ttccaaaagt tcttaacgga   300
cttggaattg ccatcctttc aacttctgaa ggtttgctta ctgataaaga agcacgccaa   360
aagaatgttg gtggtgaggt tatcgcttac gtttgg                             396

<210>   264
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S8 (rpsH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902247 (3.E-71)

<400>   264
Met Val Met Thr Asp Pro Ile Ala Asp Phe Leu Thr Arg Ile Arg Asn 
1               5                   10                  15      

Ala Asn Gln Ala Lys His Glu Val Leu Glu Val Pro Ala Ser Asn Ile 
            20                  25                  30          

Lys Lys Gly Ile Ala Glu Ile Leu Lys Arg Glu Gly Phe Val Lys Asn 
        35                  40                  45              

Val Glu Ile Ile Glu Asp Asp Lys Gln Gly Val Ile Arg Val Phe Leu 
    50                  55                  60                  

Lys Tyr Gly Pro Asn Gly Glu Lys Val Ile Thr Asn Leu Lys Arg Val 
65                  70                  75                  80  

Ser Lys Pro Gly Leu Arg Val Tyr Lys Lys Arg Glu Asp Leu Pro Lys 
                85                  90                  95      

Val Leu Asn Gly Leu Gly Ile Ala Ile Leu Ser Thr Ser Glu Gly Leu 
            100                 105                 110         

Leu Thr Asp Lys Glu Ala Arg Gln Lys Asn Val Gly Gly Glu Val Ile 
        115                 120                 125             

Ala Tyr Val Trp 
    130         

<210>   265
<211>   534
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   265
atgtcacgta ttggtaataa agttatcgtg ttgcctgctg gtgttgaact cgctaacaat   60
gacaacgttg taactgtaaa aggatctaaa ggagaactta ctcgtgagtt ctcaaaagat   120
attgaaatcc gtgtggaagg tactgaaata actcttcacc gtccaaacga ttcaaaagaa   180
atgaaaacta tccacggaac tactcgtgcc cttttgaaca acatggttgt tggtgtatca   240
gaaggattca agaaagaact tgaaatgcgt ggggttggtt accgtgcaca gcttcaagga   300
tctaaacttg ttttggctgt tggtaaatct catccagacg aagttgaagc tccagaagga   360
attacttttg aacttccaaa cccaacaaca atcgttgtta gcggaatttc aaaagaagta   420
gttggtcaaa cagctgctta cgtacgtagc cttcgttcac cagaaccata taaaggtaaa   480
ggtatccgtt acgttggtga attcgttcgc cgtaaagaag gtaaaacagg taaa         534

<210>   266
<211>   178
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L6 (rplF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902248 (1.E-97)

<400>   266
Met Ser Arg Ile Gly Asn Lys Val Ile Val Leu Pro Ala Gly Val Glu 
1               5                   10                  15      

Leu Ala Asn Asn Asp Asn Val Val Thr Val Lys Gly Ser Lys Gly Glu 
            20                  25                  30          

Leu Thr Arg Glu Phe Ser Lys Asp Ile Glu Ile Arg Val Glu Gly Thr 
        35                  40                  45              

Glu Ile Thr Leu His Arg Pro Asn Asp Ser Lys Glu Met Lys Thr Ile 
    50                  55                  60                  

His Gly Thr Thr Arg Ala Leu Leu Asn Asn Met Val Val Gly Val Ser 
65                  70                  75                  80  

Glu Gly Phe Lys Lys Glu Leu Glu Met Arg Gly Val Gly Tyr Arg Ala 
                85                  90                  95      

Gln Leu Gln Gly Ser Lys Leu Val Leu Ala Val Gly Lys Ser His Pro 
            100                 105                 110         

Asp Glu Val Glu Ala Pro Glu Gly Ile Thr Phe Glu Leu Pro Asn Pro 
        115                 120                 125             

Thr Thr Ile Val Val Ser Gly Ile Ser Lys Glu Val Val Gly Gln Thr 
    130                 135                 140                 

Ala Ala Tyr Val Arg Ser Leu Arg Ser Pro Glu Pro Tyr Lys Gly Lys 
145                 150                 155                 160 

Gly Ile Arg Tyr Val Gly Glu Phe Val Arg Arg Lys Glu Gly Lys Thr 
                165                 170                 175     

Gly Lys 
        

<210>   267
<211>   354
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   267
gtgatttcaa aaccagataa aaacaaactc cgccaaaaac gccaccgtcg cgttcgcgga   60
aaactctctg gaactgctga tcgcccacgt ttgaacgtat tccgttctaa tacaggcatc   120
tacgctcaag tgattgatga cgtagcgggt gtaacgctcg caagtgcttc aactcttgat   180
aaagaagttt caaaaggaac taaaactgaa caagccgttg ctgtcggtaa actcgttgca   240
gaacgtgcaa acgctaaagg tatttcagaa gtggtgttcg accgcggtgg atatctatat   300
cacggacgtg tgaaagcttt ggctgatgca gctcgtgaaa acggattgaa attc         354

<210>   268
<211>   118
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L18 (rplR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902249 (2.E-62)

<400>   268
Met Ile Ser Lys Pro Asp Lys Asn Lys Leu Arg Gln Lys Arg His Arg 

1               5                   10                  15      

Arg Val Arg Gly Lys Leu Ser Gly Thr Ala Asp Arg Pro Arg Leu Asn 
            20                  25                  30          

Val Phe Arg Ser Asn Thr Gly Ile Tyr Ala Gln Val Ile Asp Asp Val 
        35                  40                  45              

Ala Gly Val Thr Leu Ala Ser Ala Ser Thr Leu Asp Lys Glu Val Ser 
    50                  55                  60                  

Lys Gly Thr Lys Thr Glu Gln Ala Val Ala Val Gly Lys Leu Val Ala 
65                  70                  75                  80  

Glu Arg Ala Asn Ala Lys Gly Ile Ser Glu Val Val Phe Asp Arg Gly 
                85                  90                  95      

Gly Tyr Leu Tyr His Gly Arg Val Lys Ala Leu Ala Asp Ala Ala Arg 
            100                 105                 110         

Glu Asn Gly Leu Lys Phe 
        115             

<210>   269
<211>   492
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   269
atggcattta aagacaatgc agttgaatta gaagaacgcg tagttgctgt caaccgtgtt   60
acaaaagttg ttaaaggtgg acgtcgtctt cgtttcgcag ctcttgttgt tgttggtgac   120
cacaatggtc gcgtaggatt tggtactggt aaagctcaag aagttccaga agcaatccgt   180
aaagcagtag atgatgctaa gaaaaacttg atcgaagttc ctatggttgg aacaacaatc   240
ccacacgaag ttctttcaga attcggtgga gctaaagtat tgttgaaacc tgctgtagaa   300
ggttctggag ttgccgctgg tggtgcagtt cgtgccgttg tggaattggc aggtgtggca   360
gatattacat ctaaatcact tggttctaac actccaatca acattgttcg tgcaactgtt   420
gaaggtttga aacaattgaa acgcgctgaa gaaattgctg cccttcgtgg tatttcagtt   480
tctgatttgg ca                                                       492

<210>   270
<211>   164
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S5 (rpsE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902250 (2.E-86)

<400>   270
Met Ala Phe Lys Asp Asn Ala Val Glu Leu Glu Glu Arg Val Val Ala 
1               5                   10                  15      

Val Asn Arg Val Thr Lys Val Val Lys Gly Gly Arg Arg Leu Arg Phe 
            20                  25                  30          

Ala Ala Leu Val Val Val Gly Asp His Asn Gly Arg Val Gly Phe Gly 
        35                  40                  45              

Thr Gly Lys Ala Gln Glu Val Pro Glu Ala Ile Arg Lys Ala Val Asp 
    50                  55                  60                  

Asp Ala Lys Lys Asn Leu Ile Glu Val Pro Met Val Gly Thr Thr Ile 
65                  70                  75                  80  

Pro His Glu Val Leu Ser Glu Phe Gly Gly Ala Lys Val Leu Leu Lys 
                85                  90                  95      

Pro Ala Val Glu Gly Ser Gly Val Ala Ala Gly Gly Ala Val Arg Ala 
            100                 105                 110         

Val Val Glu Leu Ala Gly Val Ala Asp Ile Thr Ser Lys Ser Leu Gly 
        115                 120                 125             

Ser Asn Thr Pro Ile Asn Ile Val Arg Ala Thr Val Glu Gly Leu Lys 
    130                 135                 140                 

Gln Leu Lys Arg Ala Glu Glu Ile Ala Ala Leu Arg Gly Ile Ser Val 
145                 150                 155                 160 

Ser Asp Leu Ala 
                

<210>   271
<211>   222
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   271
gtggtatttc agtttctgat ttggcataag aaaggggata aaatggctca aattaaaatt   60
actttgacta agtctccaat cggacgcatt ccatcacaac gtaaaactgt tgtagcactt   120
ggacttggca aattgaacag ctctgttatt aaagaagata acgctgctat ccgtggtatg   180
atcacagcag tatctcactt agtaacagtt gaagaagtaa ac                      222

<210>   272
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L30 (rpmD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902251 (3.E-28)

<400>   272
Met Val Phe Gln Phe Leu Ile Trp His Lys Lys Gly Asp Lys Met Ala 
1               5                   10                  15      

Gln Ile Lys Ile Thr Leu Thr Lys Ser Pro Ile Gly Arg Ile Pro Ser 
            20                  25                  30          

Gln Arg Lys Thr Val Val Ala Leu Gly Leu Gly Lys Leu Asn Ser Ser 
        35                  40                  45              

Val Ile Lys Glu Asp Asn Ala Ala Ile Arg Gly Met Ile Thr Ala Val 
    50                  55                  60                  

Ser His Leu Val Thr Val Glu Glu Val Asn 
65                  70                  

<210>   273
<211>   438
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   273
atgaaacttc atgaattgaa acctgcagaa ggttctcgta aagtacgtaa ccgcgttggt   60
cgtggtactt catcaggtaa cggtaaaaca tctggtcgtg gtcaaaaagg tcaaaaagct   120
cgtagcggtg gcggagttcg ccttggtttt gaaggtggac aaactccatt gttccgtcgt   180
cttccaaaac gtggattcac taacatcaac gctaaagaat acgcaattgt gaaccttgac   240
caattgaacg tctttgaaga tggtgctgaa gtaactccag ttgttcttat cgaagcagga   300
attgttaaag ctgaaaagtc aggtattaaa attcttggta acggtgagtt gactaagaaa   360
ttgactgtga aagcagctaa attctctaaa tcagctgaag aagctatcac tgctaaaggt   420
ggttcagtag aagtcatc                                                 438

<210>   274
<211>   146
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L15 (rplO)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902252 (1.E-78)

<400>   274
Met Lys Leu His Glu Leu Lys Pro Ala Glu Gly Ser Arg Lys Val Arg 
1               5                   10                  15      

Asn Arg Val Gly Arg Gly Thr Ser Ser Gly Asn Gly Lys Thr Ser Gly 
            20                  25                  30          

Arg Gly Gln Lys Gly Gln Lys Ala Arg Ser Gly Gly Gly Val Arg Leu 
        35                  40                  45              

Gly Phe Glu Gly Gly Gln Thr Pro Leu Phe Arg Arg Leu Pro Lys Arg 
    50                  55                  60                  

Gly Phe Thr Asn Ile Asn Ala Lys Glu Tyr Ala Ile Val Asn Leu Asp 
65                  70                  75                  80  

Gln Leu Asn Val Phe Glu Asp Gly Ala Glu Val Thr Pro Val Val Leu 
                85                  90                  95      

Ile Glu Ala Gly Ile Val Lys Ala Glu Lys Ser Gly Ile Lys Ile Leu 
            100                 105                 110         

Gly Asn Gly Glu Leu Thr Lys Lys Leu Thr Val Lys Ala Ala Lys Phe 
        115                 120                 125             

Ser Lys Ser Ala Glu Glu Ala Ile Thr Ala Lys Gly Gly Ser Val Glu 
    130                 135                 140                 

Val Ile 
145     

<210>   275
<211>   1308
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   275
atgtttttta aattattaag agaagctctt aaagtcaagc aggttcgatc aaaaatttta   60
tttacaattt ttatcgtttt ggtctttcgt atcggaacta gcattacagt tcctggtgtg   120
aatgccaata gcttgaatgc tttaagtgga ttatccttct taaacatgtt gagcttggtg   180
tcggggaatg ccctaaaaaa cttttcgatt tttgccctag gagttagtcc ctatatcacc   240
gcttctattg ttgtccaact cttgcaaatg gatattttac ccaagtttgt agagtggggt   300
aaacaagggg aagtaggtcg aagaaaattg aatcaagcta ctcgttatat tgctctagtt   360
ctcgcttttg tgcaatctat cgggattaca gctggtttta ataccttggc tggagctcaa   420
ttgattaaaa ctgctttaac tccacaagtt tttctgacga ttggtatcat cttaacagct   480
ggtagtatga ttgtcacttg gttgggtgag caaattacag ataagggata cggaaacggt   540
gtttccatga ttatctttgc cgggattgtt tcctcaattc cagagatgat tcagggcatc   600
tatgtggact actttgtgaa cgtcccaagt agccgtatca cttcatctat cattttcgta   660
atcattttga ttattactgt attgttgatt atttacttta caacttatgt tcaacaagca   720
gaatacaaaa ttccaatcca atatactaag gttgcacaag gtgctccatc tagctcttac   780
cttccgttaa aagtaaaccc tgctggagtt atccctgtta tctttgccag ttcgattact   840
gcagcgcctg cggctattct tcagtttttg agtgccacag gtcatgattg ggcttgggta   900
agggtagcac aagagatgtt ggcaactact tctccaactg gtattgccat gtatgctttg   960
ttgattattc tctttacatt cttctatacg tttgtacaga ttaatcctga aaaagcagca   1020
gagagcctac aaaagagtgg tgcctatatc catggagttc gtcctggtaa aggtacagaa   1080
gaatatatgt ctaaacttct tcgtcgtctt gcaactgttg gttccctctt ccttggtgtg   1140
atttccattt taccgattgc agctaaagat gtatttggtc tttctgatgt tgttgccttt   1200
ggtggaacaa gtctcttgat cattatctct acaggtatcg aaggaatcaa gcaattggaa   1260
ggttacctat tgaaacgtaa gtatgttggt ttcatggaca gaacagaa                1308

<210>   276
<211>   436
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   preprotein translocase, SecY subunit (secY)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902253 (0.E+01)

<400>   276
Met Phe Phe Lys Leu Leu Arg Glu Ala Leu Lys Val Lys Gln Val Arg 
1               5                   10                  15      

Ser Lys Ile Leu Phe Thr Ile Phe Ile Val Leu Val Phe Arg Ile Gly 
            20                  25                  30          

Thr Ser Ile Thr Val Pro Gly Val Asn Ala Asn Ser Leu Asn Ala Leu 
        35                  40                  45              

Ser Gly Leu Ser Phe Leu Asn Met Leu Ser Leu Val Ser Gly Asn Ala 
    50                  55                  60                  

Leu Lys Asn Phe Ser Ile Phe Ala Leu Gly Val Ser Pro Tyr Ile Thr 
65                  70                  75                  80  

Ala Ser Ile Val Val Gln Leu Leu Gln Met Asp Ile Leu Pro Lys Phe 
                85                  90                  95      

Val Glu Trp Gly Lys Gln Gly Glu Val Gly Arg Arg Lys Leu Asn Gln 
            100                 105                 110         

Ala Thr Arg Tyr Ile Ala Leu Val Leu Ala Phe Val Gln Ser Ile Gly 
        115                 120                 125             

Ile Thr Ala Gly Phe Asn Thr Leu Ala Gly Ala Gln Leu Ile Lys Thr 
    130                 135                 140                 

Ala Leu Thr Pro Gln Val Phe Leu Thr Ile Gly Ile Ile Leu Thr Ala 
145                 150                 155                 160 

Gly Ser Met Ile Val Thr Trp Leu Gly Glu Gln Ile Thr Asp Lys Gly 
                165                 170                 175     

Tyr Gly Asn Gly Val Ser Met Ile Ile Phe Ala Gly Ile Val Ser Ser 
            180                 185                 190         

Ile Pro Glu Met Ile Gln Gly Ile Tyr Val Asp Tyr Phe Val Asn Val 
        195                 200                 205             

Pro Ser Ser Arg Ile Thr Ser Ser Ile Ile Phe Val Ile Ile Leu Ile 
    210                 215                 220                 

Ile Thr Val Leu Leu Ile Ile Tyr Phe Thr Thr Tyr Val Gln Gln Ala 
225                 230                 235                 240 

Glu Tyr Lys Ile Pro Ile Gln Tyr Thr Lys Val Ala Gln Gly Ala Pro 
                245                 250                 255     

Ser Ser Ser Tyr Leu Pro Leu Lys Val Asn Pro Ala Gly Val Ile Pro 
            260                 265                 270         

Val Ile Phe Ala Ser Ser Ile Thr Ala Ala Pro Ala Ala Ile Leu Gln 
        275                 280                 285             

Phe Leu Ser Ala Thr Gly His Asp Trp Ala Trp Val Arg Val Ala Gln 
    290                 295                 300                 

Glu Met Leu Ala Thr Thr Ser Pro Thr Gly Ile Ala Met Tyr Ala Leu 
305                 310                 315                 320 

Leu Ile Ile Leu Phe Thr Phe Phe Tyr Thr Phe Val Gln Ile Asn Pro 
                325                 330                 335     

Glu Lys Ala Ala Glu Ser Leu Gln Lys Ser Gly Ala Tyr Ile His Gly 
            340                 345                 350         

Val Arg Pro Gly Lys Gly Thr Glu Glu Tyr Met Ser Lys Leu Leu Arg 
        355                 360                 365             

Arg Leu Ala Thr Val Gly Ser Leu Phe Leu Gly Val Ile Ser Ile Leu 
    370                 375                 380                 

Pro Ile Ala Ala Lys Asp Val Phe Gly Leu Ser Asp Val Val Ala Phe 
385                 390                 395                 400 

Gly Gly Thr Ser Leu Leu Ile Ile Ile Ser Thr Gly Ile Glu Gly Ile 
                405                 410                 415     

Lys Gln Leu Glu Gly Tyr Leu Leu Lys Arg Lys Tyr Val Gly Phe Met 
            420                 425                 430         

Asp Arg Thr Glu 
        435     

<210>   277
<211>   636
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   277
atgaatcttt tgattatggg cttacctggt gcaggtaagg gaactcaagc agcaaaaatc   60
gtagaacaat tccatgttgc acatatctca acaggtgata tgttccgcgc tgcaatggca   120
aatcaaactg aaatgggtgt tcttgctaag tcatatattg acaagggtga attggttcct   180
gacgaagtta caaatggaat cgtaaaagaa cgcctttcac aagatgatat taaagaaaca   240
ggattcttat tggatggtta cccacgtaca attgaacaag ctcatgcctt ggacaaaaca   300
ttggctgaac ttggcattga actagaaggt gttatcaata ttgaagtgaa ccctgacagc   360
cttttggaac gtttgagtgg gcgtatcatc caccgcgtaa ctggagaaac tttccacaag   420
gtctttaacc caccagttga ctataaagaa gaagattact accaacgtga agatgataag   480
cctgagacag taaaacgtcg tttggatgtt aatattgctc aaggagaacc aatcattgct   540
cactaccgtg ccaaaggttt ggttcatgac atcgaaggta atcaagatat caatgatgtc   600
ttctcagata ttgaaaaagt attgacaaat ttgaaa                             636

<210>   278
<211>   212
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   adenylate kinase (adk)
<223>   Feature of note: secreted
<223>   Similar to strain R6 sequence 15902254 (e-120)

<400>   278
Met Asn Leu Leu Ile Met Gly Leu Pro Gly Ala Gly Lys Gly Thr Gln 
1               5                   10                  15      

Ala Ala Lys Ile Val Glu Gln Phe His Val Ala His Ile Ser Thr Gly 
            20                  25                  30          

Asp Met Phe Arg Ala Ala Met Ala Asn Gln Thr Glu Met Gly Val Leu 
        35                  40                  45              

Ala Lys Ser Tyr Ile Asp Lys Gly Glu Leu Val Pro Asp Glu Val Thr 
    50                  55                  60                  

Asn Gly Ile Val Lys Glu Arg Leu Ser Gln Asp Asp Ile Lys Glu Thr 
65                  70                  75                  80  

Gly Phe Leu Leu Asp Gly Tyr Pro Arg Thr Ile Glu Gln Ala His Ala 
                85                  90                  95      

Leu Asp Lys Thr Leu Ala Glu Leu Gly Ile Glu Leu Glu Gly Val Ile 
            100                 105                 110         


Asn Ile Glu Val Asn Pro Asp Ser Leu Leu Glu Arg Leu Ser Gly Arg 
        115                 120                 125             

Ile Ile His Arg Val Thr Gly Glu Thr Phe His Lys Val Phe Asn Pro 
    130                 135                 140                 

Pro Val Asp Tyr Lys Glu Glu Asp Tyr Tyr Gln Arg Glu Asp Asp Lys 
145                 150                 155                 160 

Pro Glu Thr Val Lys Arg Arg Leu Asp Val Asn Ile Ala Gln Gly Glu 
                165                 170                 175     

Pro Ile Ile Ala His Tyr Arg Ala Lys Gly Leu Val His Asp Ile Glu 
            180                 185                 190         

Gly Asn Gln Asp Ile Asn Asp Val Phe Ser Asp Ile Glu Lys Val Leu 
        195                 200                 205             

Thr Asn Leu Lys 
    210         

<210>   279
<211>   270
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   279
ttgttgtctc tgtgtctaga ggcatcgaat cgaaatttat ggaggtgctt ttgcgtggca   60
aaagacgatg tgattgaagt tgaaggcaaa gtagttgata caatgccgaa tgcaatgttt   120
acggttgaac ttgaaaatgg acatcagatt ttagcaacag tttctggtaa aattcgtaaa   180
aactatattc gtattttagc gggagatcgt gttactgtcg aaatgagtcc atatgacttg   240
acacgtggac gtatcactta ccgctttaaa                                    270

<210>   280
<211>   90
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   translation initiation factor IF-1 (infA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902255 (1.E-36)

<400>   280
Met Leu Ser Leu Cys Leu Glu Ala Ser Asn Arg Asn Leu Trp Arg Cys 
1               5                   10                  15      

Phe Cys Val Ala Lys Asp Asp Val Ile Glu Val Glu Gly Lys Val Val 
            20                  25                  30          

Asp Thr Met Pro Asn Ala Met Phe Thr Val Glu Leu Glu Asn Gly His 
        35                  40                  45              

Gln Ile Leu Ala Thr Val Ser Gly Lys Ile Arg Lys Asn Tyr Ile Arg 
    50                  55                  60                  

Ile Leu Ala Gly Asp Arg Val Thr Val Glu Met Ser Pro Tyr Asp Leu 
65                  70                  75                  80  

Thr Arg Gly Arg Ile Thr Tyr Arg Phe Lys 
                85                  90  

<210>   281
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   281
atgaaagtaa gaccatcggt caaaccaatt tgcgaatact gtaaagttat tcgtcgtaat   60
ggtcgtgtta tggtaatttg cccagcaaat ccaaaacaca aacaacgtca agga         114

<210>   282
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L36 (rpmJ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902256 (3.E-19)

<400>   282
Met Lys Val Arg Pro Ser Val Lys Pro Ile Cys Glu Tyr Cys Lys Val 
1               5                   10                  15      

Ile Arg Arg Asn Gly Arg Val Met Val Ile Cys Pro Ala Asn Pro Lys 
            20                  25                  30          

His Lys Gln Arg Gln Gly 
        35              

<210>   283
<211>   363
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   283
atggctcgta ttgctggagt tgatattcca aatgacaaac gcgtagtaat ctcattgact   60
tatgtttatg gtatcggact tgcaacatct aagaaaattt tggctgctgc tggaatctca   120
gaagatgttc gtgtacgtga tcttacatca gatcaagaag atgctatccg tcgtgaagtg   180
gatgcaatca aagttgaagg tgaccttcgt cgtgaagtaa acttgaacat caaacgtttg   240
atggaaatcg gttcataccg tggtatccgt caccgtcgtg gacttcctgt ccgtggacaa   300
aacactaaaa acaacgcccg cactcgtaaa ggtaaagctg ttgcgattgc tggtaagaaa   360
aaa                                                                 363

<210>   284
<211>   121
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S13 (rpsM)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902257 (2.E-63)

<400>   284
Met Ala Arg Ile Ala Gly Val Asp Ile Pro Asn Asp Lys Arg Val Val 
1               5                   10                  15      

Ile Ser Leu Thr Tyr Val Tyr Gly Ile Gly Leu Ala Thr Ser Lys Lys 
            20                  25                  30          

Ile Leu Ala Ala Ala Gly Ile Ser Glu Asp Val Arg Val Arg Asp Leu 
        35                  40                  45              

Thr Ser Asp Gln Glu Asp Ala Ile Arg Arg Glu Val Asp Ala Ile Lys 
    50                  55                  60                  

Val Glu Gly Asp Leu Arg Arg Glu Val Asn Leu Asn Ile Lys Arg Leu 
65                  70                  75                  80  

Met Glu Ile Gly Ser Tyr Arg Gly Ile Arg His Arg Arg Gly Leu Pro 
                85                  90                  95      

Val Arg Gly Gln Asn Thr Lys Asn Asn Ala Arg Thr Arg Lys Gly Lys 
            100                 105                 110         

Ala Val Ala Ile Ala Gly Lys Lys Lys 
        115                 120     

<210>   285
<211>   381
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   285
ttggctaaac caacacgtaa acgtcgtgtg aaaaagaata tcgaatctgg tattgctcat   60
attcacgcta catttaataa cactattgtt atgattactg atgtgcatgg taatgcaatt   120
gcttggtcat cagctggtgc tcttggtttc aaaggttctc gtaaatctac accattcgct   180
gctcaaatgg cttctgaagc tgctgctaaa tctgcacaag aacacggtct taaatcagtt   240
gaagttactg taaaaggtcc aggttctggt cgtgagtcag ctattcgtgc gcttgctgcc   300
gctggtcttg aagtaacagc aattcgtgat gtgactccag tgccacacaa tggtgctcgt   360
cctccaaaac gtcgccgtgt a                                             381

<210>   286
<211>   127
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S11 (rpsK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902258 (2.E-68)

<400>   286

Met Ala Lys Pro Thr Arg Lys Arg Arg Val Lys Lys Asn Ile Glu Ser 
1               5                   10                  15      

Gly Ile Ala His Ile His Ala Thr Phe Asn Asn Thr Ile Val Met Ile 
            20                  25                  30          

Thr Asp Val His Gly Asn Ala Ile Ala Trp Ser Ser Ala Gly Ala Leu 
        35                  40                  45              

Gly Phe Lys Gly Ser Arg Lys Ser Thr Pro Phe Ala Ala Gln Met Ala 
    50                  55                  60                  

Ser Glu Ala Ala Ala Lys Ser Ala Gln Glu His Gly Leu Lys Ser Val 
65                  70                  75                  80  

Glu Val Thr Val Lys Gly Pro Gly Ser Gly Arg Glu Ser Ala Ile Arg 
                85                  90                  95      

Ala Leu Ala Ala Ala Gly Leu Glu Val Thr Ala Ile Arg Asp Val Thr 
            100                 105                 110         

Pro Val Pro His Asn Gly Ala Arg Pro Pro Lys Arg Arg Arg Val 
        115                 120                 125         

<210>   287
<211>   933
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   287
atgatcgagt ttgaaaaacc aaatataaca aaaattgatg aaaataaaga ttatggcaag   60
tttgtaatcg aaccacttga acgtggctac ggtacaactc ttggtaactc tcttcgtcgt   120
gtacttctag cttctctacc aggagcagct gtgacatcta tcaacattga tggtgtgtta   180
catgagtttg acacagttcc aggtgttcgt gaagacgtga tgcaaatcat tctgaacatt   240
aaaggaattg cagtgaaatc gtacgttgaa gacgaaaaaa tcatcgaact ggatgttgaa   300
ggtcctgctg aagtaacagc tggtgacatt ttgacagata gcgatattga aattgtaaat   360
ccagatcatt atctctttac aatcggtgaa ggttcttctc taaaagcgac tatgactgtt   420
aacagtggtc gtggatatgt acctgctgat gaaaataaaa aggataatgc accagttgga   480
acacttgctg tagattctat ttatacacca gttacaaaag tcaactatca agtggaacct   540
gctcgtgtag gtagcaatga tggtttcgac aaattaaccc ttgaaatctt gacaaatgga   600
acaattattc cagaagatgc tttagggctt tcagcacgta ttttgacaga acatcttgat   660
ttgtttacaa atcttactga gattgctaag tcaactgaag tgatgaaaga agctgatact   720
gaatctgacg accgtatttt agatcgtacg attgaggaac tggacttgtc tgtgcgttca   780
tacaactgtt taaaacgtgc cggtatcaat actgtgcatg atttgacaga aaaatctgaa   840
gcagagatga tgaaagtacg aaatcttgga cgcaagagtt tggaagaagt gaaactcaaa   900
ctcattgatt tgggtcttgg attaaaagat aaa                                933

<210>   288
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-directed RNA polymerase, alpha subunit (rpoA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902259 (e-175)

<400>   288
Met Ile Glu Phe Glu Lys Pro Asn Ile Thr Lys Ile Asp Glu Asn Lys 
1               5                   10                  15      

Asp Tyr Gly Lys Phe Val Ile Glu Pro Leu Glu Arg Gly Tyr Gly Thr 
            20                  25                  30          

Thr Leu Gly Asn Ser Leu Arg Arg Val Leu Leu Ala Ser Leu Pro Gly 
        35                  40                  45              

Ala Ala Val Thr Ser Ile Asn Ile Asp Gly Val Leu His Glu Phe Asp 
    50                  55                  60                  

Thr Val Pro Gly Val Arg Glu Asp Val Met Gln Ile Ile Leu Asn Ile 
65                  70                  75                  80  

Lys Gly Ile Ala Val Lys Ser Tyr Val Glu Asp Glu Lys Ile Ile Glu 
                85                  90                  95      

Leu Asp Val Glu Gly Pro Ala Glu Val Thr Ala Gly Asp Ile Leu Thr 
            100                 105                 110         

Asp Ser Asp Ile Glu Ile Val Asn Pro Asp His Tyr Leu Phe Thr Ile 
        115                 120                 125             

Gly Glu Gly Ser Ser Leu Lys Ala Thr Met Thr Val Asn Ser Gly Arg 
    130                 135                 140                 

Gly Tyr Val Pro Ala Asp Glu Asn Lys Lys Asp Asn Ala Pro Val Gly 
145                 150                 155                 160 

Thr Leu Ala Val Asp Ser Ile Tyr Thr Pro Val Thr Lys Val Asn Tyr 
                165                 170                 175     

Gln Val Glu Pro Ala Arg Val Gly Ser Asn Asp Gly Phe Asp Lys Leu 
            180                 185                 190         

Thr Leu Glu Ile Leu Thr Asn Gly Thr Ile Ile Pro Glu Asp Ala Leu 
        195                 200                 205             

Gly Leu Ser Ala Arg Ile Leu Thr Glu His Leu Asp Leu Phe Thr Asn 
    210                 215                 220                 

Leu Thr Glu Ile Ala Lys Ser Thr Glu Val Met Lys Glu Ala Asp Thr 
225                 230                 235                 240 

Glu Ser Asp Asp Arg Ile Leu Asp Arg Thr Ile Glu Glu Leu Asp Leu 
                245                 250                 255     

Ser Val Arg Ser Tyr Asn Cys Leu Lys Arg Ala Gly Ile Asn Thr Val 
            260                 265                 270         

His Asp Leu Thr Glu Lys Ser Glu Ala Glu Met Met Lys Val Arg Asn 
        275                 280                 285             

Leu Gly Arg Lys Ser Leu Glu Glu Val Lys Leu Lys Leu Ile Asp Leu 
    290                 295                 300                 

Gly Leu Gly Leu Lys Asp Lys 
305                 310     

<210>   289
<211>   384
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   289
atggcttacc gtaaactagg acgcactagc tcacaacgta aagcaatgct tcgcgatttg   60
acaactgacc ttttgatcaa cgaatcaatc gtgacaactg aagctcgtgc taaagaaatc   120
cgtaaaactg ttgaaaaaat gattactcta ggtaaacgtg gtgatttgca tgcacgtcgt   180
caagcagctg ctttcgtacg taatgaaatc gcatctgaaa actatgatga agcaactgat   240
aagtacactt ctactacagc acttcaaaaa ttgttctcag aaatcgcacc tcgttatgct   300
gaacgtaacg gtggatacac tcgtatcctt aaaactgaat cacgtcgtgg tgatgcagcg   360
ccaatggcga tcatcgaatt agta                                          384

<210>   290
<211>   128
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L17 (rplQ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902260 (1.E-66)

<400>   290
Met Ala Tyr Arg Lys Leu Gly Arg Thr Ser Ser Gln Arg Lys Ala Met 
1               5                   10                  15      

Leu Arg Asp Leu Thr Thr Asp Leu Leu Ile Asn Glu Ser Ile Val Thr 
            20                  25                  30          

Thr Glu Ala Arg Ala Lys Glu Ile Arg Lys Thr Val Glu Lys Met Ile 
        35                  40                  45              

Thr Leu Gly Lys Arg Gly Asp Leu His Ala Arg Arg Gln Ala Ala Ala 
    50                  55                  60                  

Phe Val Arg Asn Glu Ile Ala Ser Glu Asn Tyr Asp Glu Ala Thr Asp 
65                  70                  75                  80  

Lys Tyr Thr Ser Thr Thr Ala Leu Gln Lys Leu Phe Ser Glu Ile Ala 
                85                  90                  95      

Pro Arg Tyr Ala Glu Arg Asn Gly Gly Tyr Thr Arg Ile Leu Lys Thr 
            100                 105                 110         

Glu Ser Arg Arg Gly Asp Ala Ala Pro Met Ala Ile Ile Glu Leu Val 
        115                 120                 125             


<210>   291
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   291
atgaaagcca ttataactgt tgttggtaaa gataaatctg gaattgttgc aggtgtttct   60
ggtaaaattg cagaattagg attgaatatt gacgatatct ctcaaactgt cttggatgaa   120
tattttacga tgatggctgt tgtatctagt gatgaaaagc aagattttac ctatcttcgt   180
aatgaatttg aagcttttgg gcaaactttg aatgtaaaaa tcaatattca gagtgcagcg   240
attttcgaag ctatgtataa tatc                                          264

<210>   292
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ACT domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902261 (1.E-44)

<400>   292
Met Lys Ala Ile Ile Thr Val Val Gly Lys Asp Lys Ser Gly Ile Val 
1               5                   10                  15      

Ala Gly Val Ser Gly Lys Ile Ala Glu Leu Gly Leu Asn Ile Asp Asp 
            20                  25                  30          

Ile Ser Gln Thr Val Leu Asp Glu Tyr Phe Thr Met Met Ala Val Val 
        35                  40                  45              

Ser Ser Asp Glu Lys Gln Asp Phe Thr Tyr Leu Arg Asn Glu Phe Glu 
    50                  55                  60                  

Ala Phe Gly Gln Thr Leu Asn Val Lys Ile Asn Ile Gln Ser Ala Ala 
65                  70                  75                  80  

Ile Phe Glu Ala Met Tyr Asn Ile 
                85              

<210>   293
<211>   1335
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   293
atggatatta gacaagttac tgaaaccatc gccatgattg aggagcaaaa cttcgatatt   60
agaaccatta ccatggggat ttctcttttg gactgtatcg atccagatat caatcgtgct   120
gcggagaaaa tctatcaaaa aattacgaca aaggcggcta atttagtagc tgttggtgat   180
gaaattgcgg ctgagttggg aattcctatc gttaataagc gtgtatcggt gacacctatt   240
tctctgattg gggcagcgac agatgcgacg gactacgtgg ttctggcaaa agcgcttgat   300
aaggctgcga aagagattgg tgtggacttt attggtggtt tttctgcctt agtacaaaaa   360
ggttatcaaa agggagatga gattctcatc aattccattc ctcgcgcttt ggctgagacg   420
gataaggtct gctcgtcagt caatatcggc tcaaccaagt ctggtattaa tatgacggct   480
gtggcagata tgggacgaat tatcaaggaa acagcaaatc tttcagatat gggagtggcc   540
aagttggttg tattcgctaa tgctgttgag gacaatccat ttatggcggg tgcctttcat   600
ggtgttgggg aagcagatgt tatcatcaat gtcggagttt ctggtcctgg tgttgtgaaa   660
cgtgctttgg aaaaagttcg tggacagagc tttgatgtag tagccgaaac agttaagaaa   720
actgccttta aaatcactcg tatcggtcaa ttggttggtc aaatggccag tgagagactg   780
ggtgtggagt ttggtattgt ggacttgagt ttggcaccaa cccctgcggt tggagactct   840
gtggcacgtg tccttgagga aatggggcta gaaacagttg gcacgcatgg aacgacggct   900
gccttggccc tcttgaacga ccaagttaaa aagggtggag tgatggcctg caaccaagtc   960
ggtggtttat ctggtgcctt tatccctgtt tctgaggatg aaggaatgat tgctgcagtg   1020
caaaatggct ctcttaattt agaaaaacta gaagctatga cggctatctg ttctgttgga   1080
ttggatatga ttgccatccc agaagatacg cctgctgaaa ctattgcggc tatgattgcg   1140
gatgaagcag caatcggtgt tatcaacatg aaaacaacag ctgttcgtat cattcccaaa   1200
ggaaaagaag gcgatatgat tgagtttggt ggtctattag gaactgcacc cgttatgaag   1260
gttaatgggg cttcgtctgt cgacttcatc tctcgcggtg gacaaatccc agcaccaatt   1320
catagtttta aaaat                                                    1335

<210>   294
<211>   445
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902262 (0.E+01)

<400>   294
Met Asp Ile Arg Gln Val Thr Glu Thr Ile Ala Met Ile Glu Glu Gln 
1               5                   10                  15      

Asn Phe Asp Ile Arg Thr Ile Thr Met Gly Ile Ser Leu Leu Asp Cys 
            20                  25                  30          

Ile Asp Pro Asp Ile Asn Arg Ala Ala Glu Lys Ile Tyr Gln Lys Ile 
        35                  40                  45              

Thr Thr Lys Ala Ala Asn Leu Val Ala Val Gly Asp Glu Ile Ala Ala 
    50                  55                  60                  

Glu Leu Gly Ile Pro Ile Val Asn Lys Arg Val Ser Val Thr Pro Ile 
65                  70                  75                  80  

Ser Leu Ile Gly Ala Ala Thr Asp Ala Thr Asp Tyr Val Val Leu Ala 
                85                  90                  95      

Lys Ala Leu Asp Lys Ala Ala Lys Glu Ile Gly Val Asp Phe Ile Gly 
            100                 105                 110         

Gly Phe Ser Ala Leu Val Gln Lys Gly Tyr Gln Lys Gly Asp Glu Ile 
        115                 120                 125             

Leu Ile Asn Ser Ile Pro Arg Ala Leu Ala Glu Thr Asp Lys Val Cys 
    130                 135                 140                 

Ser Ser Val Asn Ile Gly Ser Thr Lys Ser Gly Ile Asn Met Thr Ala 
145                 150                 155                 160 

Val Ala Asp Met Gly Arg Ile Ile Lys Glu Thr Ala Asn Leu Ser Asp 
                165                 170                 175     

Met Gly Val Ala Lys Leu Val Val Phe Ala Asn Ala Val Glu Asp Asn 
            180                 185                 190         

Pro Phe Met Ala Gly Ala Phe His Gly Val Gly Glu Ala Asp Val Ile 
        195                 200                 205             

Ile Asn Val Gly Val Ser Gly Pro Gly Val Val Lys Arg Ala Leu Glu 
    210                 215                 220                 

Lys Val Arg Gly Gln Ser Phe Asp Val Val Ala Glu Thr Val Lys Lys 
225                 230                 235                 240 

Thr Ala Phe Lys Ile Thr Arg Ile Gly Gln Leu Val Gly Gln Met Ala 
                245                 250                 255     

Ser Glu Arg Leu Gly Val Glu Phe Gly Ile Val Asp Leu Ser Leu Ala 
            260                 265                 270         

Pro Thr Pro Ala Val Gly Asp Ser Val Ala Arg Val Leu Glu Glu Met 
        275                 280                 285             

Gly Leu Glu Thr Val Gly Thr His Gly Thr Thr Ala Ala Leu Ala Leu 
    290                 295                 300                 

Leu Asn Asp Gln Val Lys Lys Gly Gly Val Met Ala Cys Asn Gln Val 
305                 310                 315                 320 

Gly Gly Leu Ser Gly Ala Phe Ile Pro Val Ser Glu Asp Glu Gly Met 
                325                 330                 335     

Ile Ala Ala Val Gln Asn Gly Ser Leu Asn Leu Glu Lys Leu Glu Ala 
            340                 345                 350         

Met Thr Ala Ile Cys Ser Val Gly Leu Asp Met Ile Ala Ile Pro Glu 
        355                 360                 365             

Asp Thr Pro Ala Glu Thr Ile Ala Ala Met Ile Ala Asp Glu Ala Ala 
    370                 375                 380                 

Ile Gly Val Ile Asn Met Lys Thr Thr Ala Val Arg Ile Ile Pro Lys 
385                 390                 395                 400 

Gly Lys Glu Gly Asp Met Ile Glu Phe Gly Gly Leu Leu Gly Thr Ala 
                405                 410                 415     

Pro Val Met Lys Val Asn Gly Ala Ser Ser Val Asp Phe Ile Ser Arg 
            420                 425                 430         

Gly Gly Gln Ile Pro Ala Pro Ile His Ser Phe Lys Asn 
        435                 440                 445 

<210>   295
<211>   690
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   295
atggtaaaag tacgattgta tttggtacgt catggcaaga ccatgtttaa cacgattggt   60
cgcgcgcaag gttggagcga tactccctta actgctgaag gtgaacgagg gattcaagag   120
ttaggaatcg gtttgcgaga atctgatcta cagtttgagc gtgcttattc gagtgattct   180
ggtcgtacca ttcagaccat gggaattatc cttgaagaac ttggcttgca gggggaaatc   240
ccttatcgca tggacaagcg tatcagagaa tggtgtttcg gtagttttga tggagcctat   300
gatggcgatc ttttcatggg cattattcct cgtatcttta atgtggacca cgttcaccaa   360
ttgtcttatg ctgaactggc tgagggcttg gtagaggtcg atacagctgg ttgggctgaa   420
ggctgggaaa aactcagtgg ccgaatcaag gaaggctttg aaatgattgc aaaagaaatg   480
gaagatcaag gtggaggtaa cgcccttgtt gtcagccatg gaatgactat tggaaccatt   540
gtttatctga ttaatggcat gcatccgcat ggtctggata atggtagcgt gacaatcctt   600
gaatatgagg acggccagtt tagggttgaa gttgtcggtg accgtagtta ccgagagcta   660
ggacgtgaga agatggaaga aggctctatt                                    690

<210>   296
<211>   230
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoglycerate mutase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902263 (e-133)

<400>   296
Met Val Lys Val Arg Leu Tyr Leu Val Arg His Gly Lys Thr Met Phe 
1               5                   10                  15      

Asn Thr Ile Gly Arg Ala Gln Gly Trp Ser Asp Thr Pro Leu Thr Ala 
            20                  25                  30          

Glu Gly Glu Arg Gly Ile Gln Glu Leu Gly Ile Gly Leu Arg Glu Ser 
        35                  40                  45              

Asp Leu Gln Phe Glu Arg Ala Tyr Ser Ser Asp Ser Gly Arg Thr Ile 
    50                  55                  60                  

Gln Thr Met Gly Ile Ile Leu Glu Glu Leu Gly Leu Gln Gly Glu Ile 
65                  70                  75                  80  

Pro Tyr Arg Met Asp Lys Arg Ile Arg Glu Trp Cys Phe Gly Ser Phe 
                85                  90                  95      

Asp Gly Ala Tyr Asp Gly Asp Leu Phe Met Gly Ile Ile Pro Arg Ile 
            100                 105                 110         

Phe Asn Val Asp His Val His Gln Leu Ser Tyr Ala Glu Leu Ala Glu 
        115                 120                 125             

Gly Leu Val Glu Val Asp Thr Ala Gly Trp Ala Glu Gly Trp Glu Lys 
    130                 135                 140                 

Leu Ser Gly Arg Ile Lys Glu Gly Phe Glu Met Ile Ala Lys Glu Met 
145                 150                 155                 160 

Glu Asp Gln Gly Gly Gly Asn Ala Leu Val Val Ser His Gly Met Thr 
                165                 170                 175     

Ile Gly Thr Ile Val Tyr Leu Ile Asn Gly Met His Pro His Gly Leu 
            180                 185                 190         

Asp Asn Gly Ser Val Thr Ile Leu Glu Tyr Glu Asp Gly Gln Phe Arg 
        195                 200                 205             

Val Glu Val Val Gly Asp Arg Ser Tyr Arg Glu Leu Gly Arg Glu Lys 
    210                 215                 220                 

Met Glu Glu Gly Ser Ile 
225                 230 

<210>   297
<211>   192
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   297
atgatttcaa aactctctac ttctatcctc ctctacaatg tcaaaacaag aacaatgact   60
gtagctattt atacagaggt tctcagagga aattacggtg tagccgcaac cttgtcaact   120
atcctgactg ttctaacagt aggttccttg ctcttgttta tgaaaatctc taaaagcaat   180
agcattacac tt                                                       192

<210>   298
<211>   64
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   permease BitF-related

<400>   298
Met Ile Ser Lys Leu Ser Thr Ser Ile Leu Leu Tyr Asn Val Lys Thr 
1               5                   10                  15      

Arg Thr Met Thr Val Ala Ile Tyr Thr Glu Val Leu Arg Gly Asn Tyr 
            20                  25                  30          

Gly Val Ala Ala Thr Leu Ser Thr Ile Leu Thr Val Leu Thr Val Gly 
        35                  40                  45              

Ser Leu Leu Leu Phe Met Lys Ile Ser Lys Ser Asn Ser Ile Thr Leu 
    50                  55                  60                  


<210>   299
<211>   831
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   299
ttgcttgtat ttatgagagc attctcagac tttggaacgc ctatgttgat tggcgaaggg   60
tatcggactt tccctgtcct gatttatacc caatttatta gcgaggttgg aggaaattct   120
gcttttgcaa ttatggcgat tatcattgcc ttggcaattt tccttatcca aaaacacatt   180
gcaaaccgct acagtttcag catgaatctg ctccatccaa ttgagcctaa aaaaactaca   240
aaaggaaaaa tggctgccat ttatgcaaca gtctacggaa ttatctttat ctctgtttta   300
cctcaaatct acttaattta tacctctttc ctaaaaacat caggtatggt atctgttaaa   360
ggttattctc caaacagtta caaggtagct ttccatcgta tgggatctgc tattttcaat   420
accattcgta tccctttgat tgccttagtt ctagttgttc tatttgcgac atttatctcc   480
tacctagccg ttagaaaacg gaatttgttt acaaacttaa ttgacagcct cagtatggta   540
ccttatattg taccaggaac cgttctaggg attgccttca tttcttcctt caatactggt   600
ctatttggaa gtggatttct tatgattaca gggactgctt tcatcttgat tatgtctcta   660
tctgccagaa gattacctta tactattcgc tcatctgttg ctagcttaca acaaatagca   720
ccaagtattg aagaagctgc tgaaagctta ggaagtagtc gtctcaatac ctttgctaag   780
attacaactc caatgatgct atctggtatc atttctggag ccatcttatc t            831

<210>   300
<211>   277
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron ABC transporter, permease protein

<400>   300
Met Leu Val Phe Met Arg Ala Phe Ser Asp Phe Gly Thr Pro Met Leu 
1               5                   10                  15      

Ile Gly Glu Gly Tyr Arg Thr Phe Pro Val Leu Ile Tyr Thr Gln Phe 
            20                  25                  30          

Ile Ser Glu Val Gly Gly Asn Ser Ala Phe Ala Ile Met Ala Ile Ile 
        35                  40                  45              

Ile Ala Leu Ala Ile Phe Leu Ile Gln Lys His Ile Ala Asn Arg Tyr 
    50                  55                  60                  

Ser Phe Ser Met Asn Leu Leu His Pro Ile Glu Pro Lys Lys Thr Thr 
65                  70                  75                  80  

Lys Gly Lys Met Ala Ala Ile Tyr Ala Thr Val Tyr Gly Ile Ile Phe 
                85                  90                  95      

Ile Ser Val Leu Pro Gln Ile Tyr Leu Ile Tyr Thr Ser Phe Leu Lys 
            100                 105                 110         

Thr Ser Gly Met Val Ser Val Lys Gly Tyr Ser Pro Asn Ser Tyr Lys 
        115                 120                 125             

Val Ala Phe His Arg Met Gly Ser Ala Ile Phe Asn Thr Ile Arg Ile 
    130                 135                 140                 

Pro Leu Ile Ala Leu Val Leu Val Val Leu Phe Ala Thr Phe Ile Ser 
145                 150                 155                 160 

Tyr Leu Ala Val Arg Lys Arg Asn Leu Phe Thr Asn Leu Ile Asp Ser 
                165                 170                 175     

Leu Ser Met Val Pro Tyr Ile Val Pro Gly Thr Val Leu Gly Ile Ala 
            180                 185                 190         

Phe Ile Ser Ser Phe Asn Thr Gly Leu Phe Gly Ser Gly Phe Leu Met 
        195                 200                 205             

Ile Thr Gly Thr Ala Phe Ile Leu Ile Met Ser Leu Ser Ala Arg Arg 
    210                 215                 220                 

Leu Pro Tyr Thr Ile Arg Ser Ser Val Ala Ser Leu Gln Gln Ile Ala 
225                 230                 235                 240 

Pro Ser Ile Glu Glu Ala Ala Glu Ser Leu Gly Ser Ser Arg Leu Asn 
                245                 250                 255     

Thr Phe Ala Lys Ile Thr Thr Pro Met Met Leu Ser Gly Ile Ile Ser 
            260                 265                 270         

Gly Ala Ile Leu Ser 
        275         

<210>   301
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   301
atgaacagta ttgacaattc tctacttgaa gcagctgaaa gcatggggtc cttcggattt   60
aaacctatcg taacggttgt tttacctctc ctagttccaa ccttactagc agctccttgc   120
ttgtattta                                                           129

<210>   302
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   302
Met Asn Ser Ile Asp Asn Ser Leu Leu Glu Ala Ala Glu Ser Met Gly 
1               5                   10                  15      

Ser Phe Gly Phe Lys Pro Ile Val Thr Val Val Leu Pro Leu Leu Val 
            20                  25                  30          

Pro Thr Leu Leu Ala Ala Pro Cys Leu Tyr Leu 
        35                  40              

<210>   303
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   303
ttggacagtt tcctctttct tcctctttct tacctatcct atctttctcg tttatcctat   60
cgttaccgtg ctcaagcaag cacttataca                                    90

<210>   304
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   304
Met Asp Ser Phe Leu Phe Leu Pro Leu Ser Tyr Leu Ser Tyr Leu Ser 
1               5                   10                  15      

Arg Leu Ser Tyr Arg Tyr Arg Ala Gln Ala Ser Thr Tyr Thr 
            20                  25                  30  

<210>   305
<211>   423
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   305
atggaacgta aaaaactaaa tatttggaca gtttcctctt tcttcctctt tcttacctat   60
cctatctttc tcgtttatcc tatcgttacc gtgctcaagc aagcacttat acatgaagga   120
caattctcac tagctaattt tgtcactttc tttagtaaag cctactactc tgagacacta   180
gtcaacagtt tcaaggtttc cattaccgct actatcactt ccttagttgt aggaacccta   240
ttagcttatc tcttctctat gtatgacttc aaggggaaga aatttctaca aatattgatt   300
atcattgctt ccatgtcagc tcctttcgta ggagcctact cctgggttct cttgctagga   360
cgaaatgagg tcatcactaa atttttgaca aatgcccttt atcttccagc tatcgatatt   420
tat                                                                 423

<210>   306
<211>   141
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron ABC transporter, permease protein POINT MUTATION, FRAMESHIFT

<400>   306
Met Glu Arg Lys Lys Leu Asn Ile Trp Thr Val Ser Ser Phe Phe Leu 
1               5                   10                  15      

Phe Leu Thr Tyr Pro Ile Phe Leu Val Tyr Pro Ile Val Thr Val Leu 
            20                  25                  30          

Lys Gln Ala Leu Ile His Glu Gly Gln Phe Ser Leu Ala Asn Phe Val 
        35                  40                  45              

Thr Phe Phe Ser Lys Ala Tyr Tyr Ser Glu Thr Leu Val Asn Ser Phe 
    50                  55                  60                  

Lys Val Ser Ile Thr Ala Thr Ile Thr Ser Leu Val Val Gly Thr Leu 
65                  70                  75                  80  

Leu Ala Tyr Leu Phe Ser Met Tyr Asp Phe Lys Gly Lys Lys Phe Leu 
                85                  90                  95      

Gln Ile Leu Ile Ile Ile Ala Ser Met Ser Ala Pro Phe Val Gly Ala 
            100                 105                 110         

Tyr Ser Trp Val Leu Leu Leu Gly Arg Asn Glu Val Ile Thr Lys Phe 
        115                 120                 125             

Leu Thr Asn Ala Leu Tyr Leu Pro Ala Ile Asp Ile Tyr 
    130                 135                 140     

<210>   307
<211>   1089
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   307
atgagtgaga tcaaaattat taacgccaaa aaaatctacc acgatgtccc tgttattgag   60
aatttgaaca ttacaattcc aaaaggaagt ctctttaccc ttcttggagc ttcaggatgt   120
gggaaaacga cccttcttcg tatgattgca ggtttcaaca gtatcgaagg tggagaattt   180
tacttcgatg atacaaaaat caataatatg gaacccagca aacgcaatat cgggatggtt   240
ttccaaaact acgctatttt cccacatttg actgtccgag acaacgttgc ttttggtctt   300
atgcaaaaga aggttccaaa agaagaattg attcaacaga ccaacaagta tcttgaactc   360
atgcaaattg ctcaatatgc ggatcgaaag cccgataaac tcagtggtgg acaacaacaa   420
cgtgtcacct tggcatgcgc cttagcggtt aatccaagtg ttctcctcat ggacgagcca   480
cttagtaatc tggaggccaa acttcgcttg gatatgcgtc aagccatccg agaaatccaa   540
cacgaagtgg gaattacaac tgtttatgta acccacgacc aagaagaagc catggctatt   600
tcagaccaaa ttgctgttat gaaagatggg gtgatccaac aaatcggccg accaaaagaa   660
ctctatcata aaccagctaa tgagtttgtg gcaaccttta tcggacgcac aaatattatc   720
cctgccaatc ttgaaaaacg gagcgacggc gcttatatcg tcttttcaga tggctatgcc   780
cttcgaatgc cagctcttga tcaggttgag gagcaagcta ttcatgtaag cattcgtccc   840
gaagagttta tcaaagatga atctggagat attgaaggaa ctattagaga tagcgtctat   900
cttggactaa atacggatta tttcattgag acaggttttg cctcaaaaat tcaagttagt   960
gaagaatcaa cttttgaaga agatctacaa aaaggcaatc gtattcgtct acgaatcaat   1020
acgcaaaaat taaacatctt ttctgcagat ggttcccaaa acctgataaa aggagtcaac   1080
catggaacg                                                           1089

<210>   308
<211>   363
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902266 (0.E+01)

<400>   308
Met Ser Glu Ile Lys Ile Ile Asn Ala Lys Lys Ile Tyr His Asp Val 
1               5                   10                  15      

Pro Val Ile Glu Asn Leu Asn Ile Thr Ile Pro Lys Gly Ser Leu Phe 
            20                  25                  30          

Thr Leu Leu Gly Ala Ser Gly Cys Gly Lys Thr Thr Leu Leu Arg Met 
        35                  40                  45              

Ile Ala Gly Phe Asn Ser Ile Glu Gly Gly Glu Phe Tyr Phe Asp Asp 
    50                  55                  60                  

Thr Lys Ile Asn Asn Met Glu Pro Ser Lys Arg Asn Ile Gly Met Val 
65                  70                  75                  80  

Phe Gln Asn Tyr Ala Ile Phe Pro His Leu Thr Val Arg Asp Asn Val 
                85                  90                  95      

Ala Phe Gly Leu Met Gln Lys Lys Val Pro Lys Glu Glu Leu Ile Gln 
            100                 105                 110         

Gln Thr Asn Lys Tyr Leu Glu Leu Met Gln Ile Ala Gln Tyr Ala Asp 
        115                 120                 125             

Arg Lys Pro Asp Lys Leu Ser Gly Gly Gln Gln Gln Arg Val Thr Leu 
    130                 135                 140                 

Ala Cys Ala Leu Ala Val Asn Pro Ser Val Leu Leu Met Asp Glu Pro 
145                 150                 155                 160 

Leu Ser Asn Leu Glu Ala Lys Leu Arg Leu Asp Met Arg Gln Ala Ile 
                165                 170                 175     

Arg Glu Ile Gln His Glu Val Gly Ile Thr Thr Val Tyr Val Thr His 
            180                 185                 190         

Asp Gln Glu Glu Ala Met Ala Ile Ser Asp Gln Ile Ala Val Met Lys 
        195                 200                 205             

Asp Gly Val Ile Gln Gln Ile Gly Arg Pro Lys Glu Leu Tyr His Lys 
    210                 215                 220                 

Pro Ala Asn Glu Phe Val Ala Thr Phe Ile Gly Arg Thr Asn Ile Ile 
225                 230                 235                 240 

Pro Ala Asn Leu Glu Lys Arg Ser Asp Gly Ala Tyr Ile Val Phe Ser 
                245                 250                 255     

Asp Gly Tyr Ala Leu Arg Met Pro Ala Leu Asp Gln Val Glu Glu Gln 
            260                 265                 270         

Ala Ile His Val Ser Ile Arg Pro Glu Glu Phe Ile Lys Asp Glu Ser 
        275                 280                 285             

Gly Asp Ile Glu Gly Thr Ile Arg Asp Ser Val Tyr Leu Gly Leu Asn 
    290                 295                 300                 

Thr Asp Tyr Phe Ile Glu Thr Gly Phe Ala Ser Lys Ile Gln Val Ser 
305                 310                 315                 320 

Glu Glu Ser Thr Phe Glu Glu Asp Leu Gln Lys Gly Asn Arg Ile Arg 
                325                 330                 335     

Leu Arg Ile Asn Thr Gln Lys Leu Asn Ile Phe Ser Ala Asp Gly Ser 
            340                 345                 350         

Gln Asn Leu Ile Lys Gly Val Asn His Gly Thr 
        355                 360             

<210>   309
<211>   1014
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   309
atgaaaaaga aatggatgta ttatgctgct tgttcttcta atgaatctgc cgatgacagt   60
tcatctgata aaggagacgg cggttcgcta gtcgtttatt caccaaactc agagggctta   120
attggagcaa ctattcctgc ctttgaagaa aaatatggta tcaaagtaga actgattcaa   180
gctggtactg gagaactttt caaaaaacta gagtcagaaa aagaagttcc tgtagctgat   240
gttatctttg gtggttctta tacacaatat actacccacg gagaactctt tgaaaactat   300
acttcaaaag aaaatgataa tgttatcaaa gaatatcaaa acacaactgg ctactctact   360
ccttatacac tagatggtag tgttttaatc gtcaaccctg atttaactaa aggcatgaac   420
atcgaaggat ataacgatct tttcaaacct gaactaaaag gaaaaatcgc aactgctgac   480
ccagcaaact cttctagcgc ctttgctcaa ttaacaaata tgctacaagc tcaaggtggt   540
tacaaagatg ataaggcttg gtcttatgta aaagatcttt tcacacttat tgatggtaaa   600
atcggttcaa gttcatctag tgtctataaa gtagtcgctg atggagaaat ggctgttggt   660
ctctcttatg aagatccagc agttaaactc ttaaatgacg gagctaacat taaggtagtc   720
tatccaaaag aaggaaccgt cttcctacct gctagtgctg ctatcgttaa aaaatctaaa   780
aatatggaaa atgccaagaa atttatcgat tttattatct ctcaagaagt acaagataca   840
cttggtacaa ccactactaa ccgtcctgtt cgtaaaaatg ctaaaacaag cgaaaacatg   900
aaaccaattg acaaaatcaa aacactcact gaagattatg attatgtcat caagaataaa   960
tcagatatcg ttaagaaata caacgaagtc tttacagata tccaatctaa acag         1014

<210>   310
<211>   338
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron ABC transporter, iron-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902267 (9.E-64)

<400>   310
Met Lys Lys Lys Trp Met Tyr Tyr Ala Ala Cys Ser Ser Asn Glu Ser 
1               5                   10                  15      

Ala Asp Asp Ser Ser Ser Asp Lys Gly Asp Gly Gly Ser Leu Val Val 
            20                  25                  30          

Tyr Ser Pro Asn Ser Glu Gly Leu Ile Gly Ala Thr Ile Pro Ala Phe 
        35                  40                  45              

Glu Glu Lys Tyr Gly Ile Lys Val Glu Leu Ile Gln Ala Gly Thr Gly 
    50                  55                  60                  

Glu Leu Phe Lys Lys Leu Glu Ser Glu Lys Glu Val Pro Val Ala Asp 
65                  70                  75                  80  

Val Ile Phe Gly Gly Ser Tyr Thr Gln Tyr Thr Thr His Gly Glu Leu 
                85                  90                  95      

Phe Glu Asn Tyr Thr Ser Lys Glu Asn Asp Asn Val Ile Lys Glu Tyr 
            100                 105                 110         

Gln Asn Thr Thr Gly Tyr Ser Thr Pro Tyr Thr Leu Asp Gly Ser Val 
        115                 120                 125             

Leu Ile Val Asn Pro Asp Leu Thr Lys Gly Met Asn Ile Glu Gly Tyr 
    130                 135                 140                 

Asn Asp Leu Phe Lys Pro Glu Leu Lys Gly Lys Ile Ala Thr Ala Asp 
145                 150                 155                 160 

Pro Ala Asn Ser Ser Ser Ala Phe Ala Gln Leu Thr Asn Met Leu Gln 
                165                 170                 175     

Ala Gln Gly Gly Tyr Lys Asp Asp Lys Ala Trp Ser Tyr Val Lys Asp 
            180                 185                 190         

Leu Phe Thr Leu Ile Asp Gly Lys Ile Gly Ser Ser Ser Ser Ser Val 
        195                 200                 205             

Tyr Lys Val Val Ala Asp Gly Glu Met Ala Val Gly Leu Ser Tyr Glu 
    210                 215                 220                 

Asp Pro Ala Val Lys Leu Leu Asn Asp Gly Ala Asn Ile Lys Val Val 
225                 230                 235                 240 

Tyr Pro Lys Glu Gly Thr Val Phe Leu Pro Ala Ser Ala Ala Ile Val 
                245                 250                 255     

Lys Lys Ser Lys Asn Met Glu Asn Ala Lys Lys Phe Ile Asp Phe Ile 
            260                 265                 270         

Ile Ser Gln Glu Val Gln Asp Thr Leu Gly Thr Thr Thr Thr Asn Arg 
        275                 280                 285             

Pro Val Arg Lys Asn Ala Lys Thr Ser Glu Asn Met Lys Pro Ile Asp 
    290                 295                 300                 

Lys Ile Lys Thr Leu Thr Glu Asp Tyr Asp Tyr Val Ile Lys Asn Lys 
305                 310                 315                 320 

Ser Asp Ile Val Lys Lys Tyr Asn Glu Val Phe Thr Asp Ile Gln Ser 
                325                 330                 335     

Lys Gln 
        

<210>   311
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   311
atgtctcatt cctttaaaaa atctctccaa aaagaaattc tccatagaag ctctatcgca   60
gcctttgtga cctcacgcgc attctccgat acagtatcac cgatt                   105

<210>   312
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   312
Met Ser His Ser Phe Lys Lys Ser Leu Gln Lys Glu Ile Leu His Arg 
1               5                   10                  15      

Ser Ser Ile Ala Ala Phe Val Thr Ser Arg Ala Phe Ser Asp Thr Val 
            20                  25                  30          

Ser Pro Ile 
        35  

<210>   313
<211>   774
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   313
atggaaatat ctaaaggaat tatttttaat attcaacact tttcaattca tgacggtccg   60
ggtattcgta caactgtttt tttaaaagga tgtcctctgc gctgtccatg gtgttctaat   120
cctgaatctc aaagaatgaa acctgaaaaa atgaaagatg ctcaacgaga gaaattcacc   180
ttagtcggtg aagaaaagac tgtagaagaa attattacag aggtattaaa agacaaagaa   240
ttttacgaag aatccggtgg aggtttaact ttatcaggag gtgaaatatt tgctcagttt   300
gaatttgcta aagccatctt aaaatcagct aaagaacatc acatacacac tgccattgaa   360
actactgcct ttgttgatca tgaaaaattt attgatttaa ttcaatatgt ggattttatc   420
tacacagacc taaaacatta taattctata aaacataaaa aagtgactgg ggtttttaat   480
caaatgatta ttaaaaacat tcattatgct ttttcacaaa ataaaactat cgttttaaga   540
atcccagtta ttcctaattt taacaatagt ttagaggatg cagaaaaatt cgctactcta   600
tttaactcat taaatatcga ccaagttcaa ctactccctt ttcatcaatt tggtgaaaac   660
aaatatcgtt tattaaatcg gaaatatgaa atggatggaa tcaacgcact tcatcctgaa   720
gatcttattg attatcaaaa ggtatttctg aaccaccata ttaattgtta tttc         774

<210>   314
<211>   258
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyruvate formate-lyase-activating enzyme, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902270 (e-152)

<400>   314
Met Glu Ile Ser Lys Gly Ile Ile Phe Asn Ile Gln His Phe Ser Ile 
1               5                   10                  15      

His Asp Gly Pro Gly Ile Arg Thr Thr Val Phe Leu Lys Gly Cys Pro 
            20                  25                  30          

Leu Arg Cys Pro Trp Cys Ser Asn Pro Glu Ser Gln Arg Met Lys Pro 
        35                  40                  45              

Glu Lys Met Lys Asp Ala Gln Arg Glu Lys Phe Thr Leu Val Gly Glu 
    50                  55                  60                  

Glu Lys Thr Val Glu Glu Ile Ile Thr Glu Val Leu Lys Asp Lys Glu 
65                  70                  75                  80  

Phe Tyr Glu Glu Ser Gly Gly Gly Leu Thr Leu Ser Gly Gly Glu Ile 
                85                  90                  95      

Phe Ala Gln Phe Glu Phe Ala Lys Ala Ile Leu Lys Ser Ala Lys Glu 
            100                 105                 110         

His His Ile His Thr Ala Ile Glu Thr Thr Ala Phe Val Asp His Glu 
        115                 120                 125             


Lys Phe Ile Asp Leu Ile Gln Tyr Val Asp Phe Ile Tyr Thr Asp Leu 
    130                 135                 140                 

Lys His Tyr Asn Ser Ile Lys His Lys Lys Val Thr Gly Val Phe Asn 
145                 150                 155                 160 

Gln Met Ile Ile Lys Asn Ile His Tyr Ala Phe Ser Gln Asn Lys Thr 
                165                 170                 175     

Ile Val Leu Arg Ile Pro Val Ile Pro Asn Phe Asn Asn Ser Leu Glu 
            180                 185                 190         

Asp Ala Glu Lys Phe Ala Thr Leu Phe Asn Ser Leu Asn Ile Asp Gln 
        195                 200                 205             

Val Gln Leu Leu Pro Phe His Gln Phe Gly Glu Asn Lys Tyr Arg Leu 
    210                 215                 220                 

Leu Asn Arg Lys Tyr Glu Met Asp Gly Ile Asn Ala Leu His Pro Glu 
225                 230                 235                 240 

Asp Leu Ile Asp Tyr Gln Lys Val Phe Leu Asn His His Ile Asn Cys 
                245                 250                 255     

Tyr Phe 
        

<210>   315
<211>   744
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   315
atgaaaagat tggaacaaat tattaaatta gtatcagaat atgaaaagat cgacgttaat   60
acattatcgg aaaaattaaa tgtatcgaaa gtaacgatta gaaaagattt agataaatta   120
gagtcaaaag gtttattaca cagagagcat ggatatgctg tattaaatag tggagatgac   180
ttaaatgtac gtttgtcaat taattatgaa actaagagaa aaattgttca ggaagcagta   240
aaattggtgt cagataatga aacaataatg atagaatctg gatcgacctg tgctttactt   300
gctgaggaaa tttgcaagca aaaaagaaat gttacgattg taacaaattc gttttttata   360
gcaaattttg tgagagctta tgattcatgt cgtgttattg ttcttggtgg tgagtttcag   420
aaagattcac aggtgactgt aggaccttta ttaaaagaaa tgatacagac ttttcatgtg   480
tgtcaagctt ttgttgggac agatggttac gataaagaga tgggctttac cggaaaagat   540
ttaatgcgca gtgaggtagt tcaatatatt tcagcagtgt cggataaagt cattgtccta   600
actgactcaa gtaaatttga taaaagaggt acagtaagaa gatttgcttt aagtcaagtc   660
tatgaagtaa taacagacga aaaactttct aaacaaaata tagctacatt agaaaatgct   720
gggataatgg ttaaggtagt ttcg                                          744

<210>   316
<211>   248
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, DeoR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902271 (e-134)

<400>   316
Met Lys Arg Leu Glu Gln Ile Ile Lys Leu Val Ser Glu Tyr Glu Lys 
1               5                   10                  15      

Ile Asp Val Asn Thr Leu Ser Glu Lys Leu Asn Val Ser Lys Val Thr 
            20                  25                  30          

Ile Arg Lys Asp Leu Asp Lys Leu Glu Ser Lys Gly Leu Leu His Arg 
        35                  40                  45              

Glu His Gly Tyr Ala Val Leu Asn Ser Gly Asp Asp Leu Asn Val Arg 
    50                  55                  60                  

Leu Ser Ile Asn Tyr Glu Thr Lys Arg Lys Ile Val Gln Glu Ala Val 
65                  70                  75                  80  

Lys Leu Val Ser Asp Asn Glu Thr Ile Met Ile Glu Ser Gly Ser Thr 
                85                  90                  95      

Cys Ala Leu Leu Ala Glu Glu Ile Cys Lys Gln Lys Arg Asn Val Thr 
            100                 105                 110         

Ile Val Thr Asn Ser Phe Phe Ile Ala Asn Phe Val Arg Ala Tyr Asp 
        115                 120                 125             

Ser Cys Arg Val Ile Val Leu Gly Gly Glu Phe Gln Lys Asp Ser Gln 
    130                 135                 140                 

Val Thr Val Gly Pro Leu Leu Lys Glu Met Ile Gln Thr Phe His Val 
145                 150                 155                 160 

Cys Gln Ala Phe Val Gly Thr Asp Gly Tyr Asp Lys Glu Met Gly Phe 
                165                 170                 175     

Thr Gly Lys Asp Leu Met Arg Ser Glu Val Val Gln Tyr Ile Ser Ala 
            180                 185                 190         

Val Ser Asp Lys Val Ile Val Leu Thr Asp Ser Ser Lys Phe Asp Lys 
        195                 200                 205             

Arg Gly Thr Val Arg Arg Phe Ala Leu Ser Gln Val Tyr Glu Val Ile 
    210                 215                 220                 

Thr Asp Glu Lys Leu Ser Lys Gln Asn Ile Ala Thr Leu Glu Asn Ala 
225                 230                 235                 240 

Gly Ile Met Val Lys Val Val Ser 
                245             

<210>   317
<211>   978
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   317
atgaatcaag ataggaataa actgctttct aaaattgctt atctgtatta tattgaaaac   60
ttaaatcagt cacaaatagc agcaaaatta ggaatttata gaacctctat tagtagaatg   120
ttaacagaag caaggaatgt aggaattgtt aaaattgaaa tagagaattt tgataccaat   180
atgtttaagt tggaaaatta tgtaaaagaa aaatacagtt tggaaagttt agaaattatt   240
ccaaatgaat ttgatgatac tccaacaatt ttatctgaaa gaatttctca agttgcagca   300
ggcgtcctta ggaatctaat tgatgataat atgaaaattg gcttttcttg ggggaaaagt   360
ttaagtaatt tagtagattt aattcacagt aaaagtgtcc gaaatgttca cttctatcct   420
ctagcaggtg gtcctagtca catacacgct aaataccatg tgaatacact gatttatgaa   480
atgtctagaa aatttcatgg agagtgtaca tttatgaatg caacgattgt gcaagaaaat   540
aaattgttag cagatggtat tttgcaatca agatattttg aaaatttgaa aaatagttgg   600
aaagatttag atatagctgt agtcggaatt ggtgatttta gcaataaagg gaaacatcaa   660
tggttagaca tgcttacaga ggatgacttt aaagaattga ccaaagttaa aactgtagga   720
gaaatttgtt gtcgattttt tgattcaaaa ggtaaagaag tctatgaaaa cttacaggaa   780
agaacgatag caatctcttt ggaagattta aaaaatattc ctcaaagttt agctgttgct   840
tacggtgata cgaaagtatc ttcgattctt tctgtcttgc gtgctaattt agtaaatcat   900
ttgattacag acaaaaatac aattttaaaa gttttggaag aagatgggga tttgactttt   960
agagagattc taggtgag                                                 978

<210>   318
<211>   326
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902272 (0.E+01)

<400>   318
Met Asn Gln Asp Arg Asn Lys Leu Leu Ser Lys Ile Ala Tyr Leu Tyr 
1               5                   10                  15      

Tyr Ile Glu Asn Leu Asn Gln Ser Gln Ile Ala Ala Lys Leu Gly Ile 
            20                  25                  30          

Tyr Arg Thr Ser Ile Ser Arg Met Leu Thr Glu Ala Arg Asn Val Gly 
        35                  40                  45              

Ile Val Lys Ile Glu Ile Glu Asn Phe Asp Thr Asn Met Phe Lys Leu 
    50                  55                  60                  

Glu Asn Tyr Val Lys Glu Lys Tyr Ser Leu Glu Ser Leu Glu Ile Ile 
65                  70                  75                  80  

Pro Asn Glu Phe Asp Asp Thr Pro Thr Ile Leu Ser Glu Arg Ile Ser 
                85                  90                  95      

Gln Val Ala Ala Gly Val Leu Arg Asn Leu Ile Asp Asp Asn Met Lys 
            100                 105                 110         

Ile Gly Phe Ser Trp Gly Lys Ser Leu Ser Asn Leu Val Asp Leu Ile 
        115                 120                 125             

His Ser Lys Ser Val Arg Asn Val His Phe Tyr Pro Leu Ala Gly Gly 
    130                 135                 140                 

Pro Ser His Ile His Ala Lys Tyr His Val Asn Thr Leu Ile Tyr Glu 
145                 150                 155                 160 

Met Ser Arg Lys Phe His Gly Glu Cys Thr Phe Met Asn Ala Thr Ile 
                165                 170                 175     

Val Gln Glu Asn Lys Leu Leu Ala Asp Gly Ile Leu Gln Ser Arg Tyr 
            180                 185                 190         

Phe Glu Asn Leu Lys Asn Ser Trp Lys Asp Leu Asp Ile Ala Val Val 
        195                 200                 205             

Gly Ile Gly Asp Phe Ser Asn Lys Gly Lys His Gln Trp Leu Asp Met 
    210                 215                 220                 

Leu Thr Glu Asp Asp Phe Lys Glu Leu Thr Lys Val Lys Thr Val Gly 
225                 230                 235                 240 

Glu Ile Cys Cys Arg Phe Phe Asp Ser Lys Gly Lys Glu Val Tyr Glu 
                245                 250                 255     

Asn Leu Gln Glu Arg Thr Ile Ala Ile Ser Leu Glu Asp Leu Lys Asn 
            260                 265                 270         

Ile Pro Gln Ser Leu Ala Val Ala Tyr Gly Asp Thr Lys Val Ser Ser 
        275                 280                 285             

Ile Leu Ser Val Leu Arg Ala Asn Leu Val Asn His Leu Ile Thr Asp 
    290                 295                 300                 

Lys Asn Thr Ile Leu Lys Val Leu Glu Glu Asp Gly Asp Leu Thr Phe 
305                 310                 315                 320 

Arg Glu Ile Leu Gly Glu 
                325     

<210>   319
<211>   318
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   319
atggaaatga ttgttccaga tcaaattatc atgggtttaa ttttatatgc tggtgatgcg   60
aaacaacata tttataaagc gttagattac ataaaaaatg gtacatgtga acggtgtgaa   120
gaagaaatac agttagctga tgcagcctta ttagaagctc ataatctaca aacaaaattt   180
ttggcacagg aagcgtctgg tacaaagaca gaaattacag ctctctttgt tcattcacaa   240
gatcatctca tgaccagtat gacggagatt aatttaatca aagaaattat tagtttgaga   300
aaagaacttc ataaaaaa                                                 318

<210>   320
<211>   106
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIA component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902273 (2.E-56)

<400>   320
Met Glu Met Ile Val Pro Asp Gln Ile Ile Met Gly Leu Ile Leu Tyr 
1               5                   10                  15      

Ala Gly Asp Ala Lys Gln His Ile Tyr Lys Ala Leu Asp Tyr Ile Lys 
            20                  25                  30          

Asn Gly Thr Cys Glu Arg Cys Glu Glu Glu Ile Gln Leu Ala Asp Ala 
        35                  40                  45              

Ala Leu Leu Glu Ala His Asn Leu Gln Thr Lys Phe Leu Ala Gln Glu 
    50                  55                  60                  

Ala Ser Gly Thr Lys Thr Glu Ile Thr Ala Leu Phe Val His Ser Gln 
65                  70                  75                  80  

Asp His Leu Met Thr Ser Met Thr Glu Ile Asn Leu Ile Lys Glu Ile 
                85                  90                  95      

Ile Ser Leu Arg Lys Glu Leu His Lys Lys 
            100                 105     

<210>   321
<211>   306
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   321
atggtgaaga ttggtttgtt ttgtgcagca ggtttttcta ctggtatgct tgtaaataat   60
atgaaaattg cagcgcaatc tagtggagtt gaggcagaaa tagaggcgtt ttctcagtct   120
aaattagcgg attatgcgcc aaatatagat gttgcactat tgggtccaca agttgcttat   180
acattagata aatcaaaaga aatttgtgat aagtgtgatg ttccgatagc tgttattccg   240
atgatggact atggtatgtt agatgggaaa aaagtattag atttggccct atctttgatt   300
agtggg                                                              306

<210>   322
<211>   102
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIB component
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902274 (2.E-53)

<400>   322
Met Val Lys Ile Gly Leu Phe Cys Ala Ala Gly Phe Ser Thr Gly Met 
1               5                   10                  15      

Leu Val Asn Asn Met Lys Ile Ala Ala Gln Ser Ser Gly Val Glu Ala 
            20                  25                  30          

Glu Ile Glu Ala Phe Ser Gln Ser Lys Leu Ala Asp Tyr Ala Pro Asn 
        35                  40                  45              

Ile Asp Val Ala Leu Leu Gly Pro Gln Val Ala Tyr Thr Leu Asp Lys 
    50                  55                  60                  

Ser Lys Glu Ile Cys Asp Lys Cys Asp Val Pro Ile Ala Val Ile Pro 
65                  70                  75                  80  

Met Met Asp Tyr Gly Met Leu Asp Gly Lys Lys Val Leu Asp Leu Ala 
                85                  90                  95      

Leu Ser Leu Ile Ser Gly 
            100         

<210>   323
<211>   1320
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   323
gtgggtaaga aaaggagatt tattatgtca aagatggatg ttcagaaaat cattgcaccg   60
atgatgaagt ttgtgaatat gcgtggcatt atagctctaa aagatgggat gttagcaatt   120
ttgccattga cagtagttgg tagtttgttc ttgattatgg gacaattgcc gttcgaagga   180
ttaaataaga gcattgctag tgtttttgga gctaattgga cagagccgtt tatgcaagta   240
tattcaggaa cttttgctat tatgggtcta atttcttgtt tttcaattgc ctattcttat   300
gctaagaata gcggagtaga ggctttacca gctggagttc tatctgtatc tgcattcttt   360
attttgctaa gatcatctta tatccctaaa caaggtgagg cgattgggga cgctattagt   420
aaagtttggt ttggaggcca aggaattatc ggtgctatca ttataggttt ggtagtagga   480
agtatttata ccttctttat aaagagaaaa attgttatta agatgccaga acaagttcca   540
caagctattg ccaaacagtt tgaagcaatg attccagcat ttgtaatttt cttatcttct   600
atgattgtat atattttagc gaagtcattg actaatggcg gaacattcat agaaatgatt   660
tattctgcta ttcaagttcc gttgcaaggt ttaactggat ctttgtatgg tgctattgga   720
attgcattct ttatatcatt tttgtggtgg tttggtgttc atgggcaatc ggtagtaaat   780
ggagtagtga cagctctgct tttatctaat cttgatgcta ataaagctat gttagcctct   840
gctaatctat cattagaaaa tggtgcacat attgttactc aacaattttt agattcattt   900
ttaattctat caggttcagg gattacgttt ggtcttgtag ttgccatgct ttttgcagca   960
aaatcaaaac aataccaagc cttaggaaaa gttgcagctt ttccagcaat atttaacgta   1020
aatgagccag ttgtatttgg atttccgatt gtcatgaatc cagttatgtt tgtacctttc   1080
attcttgttc ctgtacttgc agctgtgata gtatatggag ctattgcaac aggtttcatg   1140
cagccattct caggggtaac attgccttgg agtacaccag ctattttatc aggatttttg   1200
gtgggtggat ggcaaggagt tattactcag ctggtgatat tagcgatgtc tacattggtt   1260
tattttccat tctttaaagt acaggatcgt ttagcttacc aaaatgaaat caaacaatct   1320

<210>   324
<211>   440
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIC component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902275 (0.E+01)

<400>   324
Met Gly Lys Lys Arg Arg Phe Ile Met Ser Lys Met Asp Val Gln Lys 
1               5                   10                  15      

Ile Ile Ala Pro Met Met Lys Phe Val Asn Met Arg Gly Ile Ile Ala 
            20                  25                  30          

Leu Lys Asp Gly Met Leu Ala Ile Leu Pro Leu Thr Val Val Gly Ser 
        35                  40                  45              

Leu Phe Leu Ile Met Gly Gln Leu Pro Phe Glu Gly Leu Asn Lys Ser 
    50                  55                  60                  

Ile Ala Ser Val Phe Gly Ala Asn Trp Thr Glu Pro Phe Met Gln Val 
65                  70                  75                  80  

Tyr Ser Gly Thr Phe Ala Ile Met Gly Leu Ile Ser Cys Phe Ser Ile 
                85                  90                  95      

Ala Tyr Ser Tyr Ala Lys Asn Ser Gly Val Glu Ala Leu Pro Ala Gly 
            100                 105                 110         

Val Leu Ser Val Ser Ala Phe Phe Ile Leu Leu Arg Ser Ser Tyr Ile 
        115                 120                 125             

Pro Lys Gln Gly Glu Ala Ile Gly Asp Ala Ile Ser Lys Val Trp Phe 
    130                 135                 140                 

Gly Gly Gln Gly Ile Ile Gly Ala Ile Ile Ile Gly Leu Val Val Gly 
145                 150                 155                 160 

Ser Ile Tyr Thr Phe Phe Ile Lys Arg Lys Ile Val Ile Lys Met Pro 
                165                 170                 175     

Glu Gln Val Pro Gln Ala Ile Ala Lys Gln Phe Glu Ala Met Ile Pro 
            180                 185                 190         

Ala Phe Val Ile Phe Leu Ser Ser Met Ile Val Tyr Ile Leu Ala Lys 
        195                 200                 205             

Ser Leu Thr Asn Gly Gly Thr Phe Ile Glu Met Ile Tyr Ser Ala Ile 
    210                 215                 220                 

Gln Val Pro Leu Gln Gly Leu Thr Gly Ser Leu Tyr Gly Ala Ile Gly 
225                 230                 235                 240 

Ile Ala Phe Phe Ile Ser Phe Leu Trp Trp Phe Gly Val His Gly Gln 
                245                 250                 255     

Ser Val Val Asn Gly Val Val Thr Ala Leu Leu Leu Ser Asn Leu Asp 
            260                 265                 270         

Ala Asn Lys Ala Met Leu Ala Ser Ala Asn Leu Ser Leu Glu Asn Gly 
        275                 280                 285             

Ala His Ile Val Thr Gln Gln Phe Leu Asp Ser Phe Leu Ile Leu Ser 
    290                 295                 300                 

Gly Ser Gly Ile Thr Phe Gly Leu Val Val Ala Met Leu Phe Ala Ala 
305                 310                 315                 320 

Lys Ser Lys Gln Tyr Gln Ala Leu Gly Lys Val Ala Ala Phe Pro Ala 
                325                 330                 335     

Ile Phe Asn Val Asn Glu Pro Val Val Phe Gly Phe Pro Ile Val Met 
            340                 345                 350         

Asn Pro Val Met Phe Val Pro Phe Ile Leu Val Pro Val Leu Ala Ala 
        355                 360                 365             

Val Ile Val Tyr Gly Ala Ile Ala Thr Gly Phe Met Gln Pro Phe Ser 
    370                 375                 380                 

Gly Val Thr Leu Pro Trp Ser Thr Pro Ala Ile Leu Ser Gly Phe Leu 
385                 390                 395                 400 

Val Gly Gly Trp Gln Gly Val Ile Thr Gln Leu Val Ile Leu Ala Met 
                405                 410                 415     

Ser Thr Leu Val Tyr Phe Pro Phe Phe Lys Val Gln Asp Arg Leu Ala 
            420                 425                 430         

Tyr Gln Asn Glu Ile Lys Gln Ser 
        435                 440 

<210>   325
<211>   2436
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   325
atggtaaata cagaagtagc aagaacaaca atcaagacag aatattttgg cagccttact   60
gaaaggatga acaaatatcg agaagatgtt ttaaataaaa aaccttatat tgatgctgag   120
agagcagttc tagcaacacg cgcctatgaa cgatacaagg aacaacctaa tgtcctaaaa   180
cgtgcatata tgctgaaaga aattttggaa aatatgacta tctatattga agaagaatct   240
atgattgcgg gaaatcaagc ttcttccaat aaagatgctc ctatttttcc ggaatatacg   300
ctagaatttg ttctcaatga gttggatctt tttgaaaagc gtgatggaga tgttttctat   360
attacagaag aaacaaaaga acaacttaga agtattgctc cgttttggga aaataataat   420
ttacgtgcta gagctggtgc cttattacct gaagaagtgt ctgtttatat ggaaacagga   480
ttcttcggta tggaaggtaa gatgaattct ggagatgctc acttagcagt taactatcag   540
aaacttttgc aatttggttt aagaggtttt gaagagcggg ctcgtaaagc aaaagtagct   600
ctagatttaa cagatccagc aagtattgat aaatatcatt tttacgactc tatatttatc   660
gtaatcgatg ctattaaagt atatgcaaag cgctttgttg ctcttgctaa aagtttagcc   720
gaaaatgcaa atcctaaacg taagaaagaa ttacttgaga ttgcagatat ttgctctaga   780
gtcccatatg aaccggcaac tacttttgca gaagctattc aatcagtttg gtttattcaa   840
tgtattttac aaattgaatc taatggccac tctctttcat atggccgttt tgatcaatat   900
atgtatccat atatgaaggc tgatttagaa agtggtaaag aaacagaaga tagcattgtt   960
gaacgtctga caaatctttg gattaagaca attacaatta ataaggttcg cagtcaatca   1020
catacatttt cttcagcagg aagtccttta tatcaaaatg ttacaattgg tggacagact   1080
cgagataaga aggatgctgt taacccatta tcttatttgg tattaaaatc agttgcacaa   1140
acccatctac cgcaacctaa tctaactgta cgttaccatg caggtttaga tgctcgtttc   1200
atgaatgagt gtattgaagt gatgaaactt ggttttggta tgcctgcatt taataatgat   1260
gagattatta ttccttcttt tattgcaaaa ggagtattgg aagatgatgc ttatgattac   1320
agtgccattg gatgtgttga aacggcagtt ccagggaaat ggggctatcg ttgcacaggt   1380
atgagttata tgaacttccc taaggttcta cttatcacga tgaatgatgg aattgatccg   1440
gcttcgggta aacggtttgc accaagcttt ggtcgtttta aggatatgaa gaacttttct   1500
gaattagaaa atgcttggga taaaacacta agatatttga cacgaatgag tgttattgtt   1560
gaaaattcta ttgatttatc attggaacga gaagttcctg atattctatg ttcagcattg   1620
actgatgatt gtattggtcg tggaaaacac cttaaagaag gtggagcagt atatgattat   1680
atatcaggat tgcaagttgg aattgcaaat ttgtcggatt cattagctgc aattaaaaaa   1740
ttggtgtttg aggaagaacg tataagccca agtcagcttt ggcatgcact ggaaacagat   1800
tatgccggag aagaaggtaa ggtcattcaa gaaatgttga ttcatgatgc acctaagtat   1860
ggtaatgatg atgattatgc tgacaaattg gttactgctg cttatgacat ttatgttgat   1920
gaaattgcta aatatcctaa tacacgttat ggaagagggc ctattggagg aattcgttat   1980
tcaggaacat cttctatctc agccaacgta gggcagggac gtggaacatt agcaactcca   2040
gatggacgca acgcgggtac accgttagca gagggttgtt caccatcaca taatatggat   2100
caacacggcc ctacatctgt tttaaaatct gtttcaaaat taccaacaga tgaaatcgta   2160
ggtggggttc tcttaaatca gaaagtaaat cctcaaacgt tagccaaaga agaagataaa   2220
ttaaaactaa ttgctttgtt acgaacattc tttaatcgtt tacatgggta ccatattcaa   2280
tacaatgttg tttccagaga gacgctgatt gacgctcaga aacatcctga aaaacacaga   2340
gacttaattg ttcgtgttgc aggatactct gcattcttca atgttctttc taaggcaacc   2400
caagatgaca ttataggacg tactgagcat actttg                             2436

<210>   326
<211>   812
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   formate acetyltransferase, putative ( )
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902276 (0.E+01)

<400>   326
Met Val Asn Thr Glu Val Ala Arg Thr Thr Ile Lys Thr Glu Tyr Phe 
1               5                   10                  15      

Gly Ser Leu Thr Glu Arg Met Asn Lys Tyr Arg Glu Asp Val Leu Asn 
            20                  25                  30          

Lys Lys Pro Tyr Ile Asp Ala Glu Arg Ala Val Leu Ala Thr Arg Ala 
        35                  40                  45              

Tyr Glu Arg Tyr Lys Glu Gln Pro Asn Val Leu Lys Arg Ala Tyr Met 
    50                  55                  60                  

Leu Lys Glu Ile Leu Glu Asn Met Thr Ile Tyr Ile Glu Glu Glu Ser 
65                  70                  75                  80  

Met Ile Ala Gly Asn Gln Ala Ser Ser Asn Lys Asp Ala Pro Ile Phe 
                85                  90                  95      

Pro Glu Tyr Thr Leu Glu Phe Val Leu Asn Glu Leu Asp Leu Phe Glu 
            100                 105                 110         

Lys Arg Asp Gly Asp Val Phe Tyr Ile Thr Glu Glu Thr Lys Glu Gln 
        115                 120                 125             

Leu Arg Ser Ile Ala Pro Phe Trp Glu Asn Asn Asn Leu Arg Ala Arg 
    130                 135                 140                 

Ala Gly Ala Leu Leu Pro Glu Glu Val Ser Val Tyr Met Glu Thr Gly 
145                 150                 155                 160 

Phe Phe Gly Met Glu Gly Lys Met Asn Ser Gly Asp Ala His Leu Ala 
                165                 170                 175     

Val Asn Tyr Gln Lys Leu Leu Gln Phe Gly Leu Arg Gly Phe Glu Glu 
            180                 185                 190         

Arg Ala Arg Lys Ala Lys Val Ala Leu Asp Leu Thr Asp Pro Ala Ser 
        195                 200                 205             

Ile Asp Lys Tyr His Phe Tyr Asp Ser Ile Phe Ile Val Ile Asp Ala 
    210                 215                 220                 

Ile Lys Val Tyr Ala Lys Arg Phe Val Ala Leu Ala Lys Ser Leu Ala 
225                 230                 235                 240 

Glu Asn Ala Asn Pro Lys Arg Lys Lys Glu Leu Leu Glu Ile Ala Asp 
                245                 250                 255     

Ile Cys Ser Arg Val Pro Tyr Glu Pro Ala Thr Thr Phe Ala Glu Ala 
            260                 265                 270         

Ile Gln Ser Val Trp Phe Ile Gln Cys Ile Leu Gln Ile Glu Ser Asn 
        275                 280                 285             

Gly His Ser Leu Ser Tyr Gly Arg Phe Asp Gln Tyr Met Tyr Pro Tyr 
    290                 295                 300                 

Met Lys Ala Asp Leu Glu Ser Gly Lys Glu Thr Glu Asp Ser Ile Val 
305                 310                 315                 320 

Glu Arg Leu Thr Asn Leu Trp Ile Lys Thr Ile Thr Ile Asn Lys Val 
                325                 330                 335     

Arg Ser Gln Ser His Thr Phe Ser Ser Ala Gly Ser Pro Leu Tyr Gln 
            340                 345                 350         

Asn Val Thr Ile Gly Gly Gln Thr Arg Asp Lys Lys Asp Ala Val Asn 
        355                 360                 365             

Pro Leu Ser Tyr Leu Val Leu Lys Ser Val Ala Gln Thr His Leu Pro 
    370                 375                 380                 

Gln Pro Asn Leu Thr Val Arg Tyr His Ala Gly Leu Asp Ala Arg Phe 
385                 390                 395                 400 

Met Asn Glu Cys Ile Glu Val Met Lys Leu Gly Phe Gly Met Pro Ala 
                405                 410                 415     

Phe Asn Asn Asp Glu Ile Ile Ile Pro Ser Phe Ile Ala Lys Gly Val 
            420                 425                 430         

Leu Glu Asp Asp Ala Tyr Asp Tyr Ser Ala Ile Gly Cys Val Glu Thr 
        435                 440                 445             

Ala Val Pro Gly Lys Trp Gly Tyr Arg Cys Thr Gly Met Ser Tyr Met 
    450                 455                 460                 

Asn Phe Pro Lys Val Leu Leu Ile Thr Met Asn Asp Gly Ile Asp Pro 
465                 470                 475                 480 

Ala Ser Gly Lys Arg Phe Ala Pro Ser Phe Gly Arg Phe Lys Asp Met 
                485                 490                 495     

Lys Asn Phe Ser Glu Leu Glu Asn Ala Trp Asp Lys Thr Leu Arg Tyr 
            500                 505                 510         

Leu Thr Arg Met Ser Val Ile Val Glu Asn Ser Ile Asp Leu Ser Leu 
        515                 520                 525             

Glu Arg Glu Val Pro Asp Ile Leu Cys Ser Ala Leu Thr Asp Asp Cys 
    530                 535                 540                 

Ile Gly Arg Gly Lys His Leu Lys Glu Gly Gly Ala Val Tyr Asp Tyr 
545                 550                 555                 560 

Ile Ser Gly Leu Gln Val Gly Ile Ala Asn Leu Ser Asp Ser Leu Ala 
                565                 570                 575     

Ala Ile Lys Lys Leu Val Phe Glu Glu Glu Arg Ile Ser Pro Ser Gln 
            580                 585                 590         

Leu Trp His Ala Leu Glu Thr Asp Tyr Ala Gly Glu Glu Gly Lys Val 
        595                 600                 605             

Ile Gln Glu Met Leu Ile His Asp Ala Pro Lys Tyr Gly Asn Asp Asp 
    610                 615                 620                 

Asp Tyr Ala Asp Lys Leu Val Thr Ala Ala Tyr Asp Ile Tyr Val Asp 
625                 630                 635                 640 

Glu Ile Ala Lys Tyr Pro Asn Thr Arg Tyr Gly Arg Gly Pro Ile Gly 
                645                 650                 655     

Gly Ile Arg Tyr Ser Gly Thr Ser Ser Ile Ser Ala Asn Val Gly Gln 
            660                 665                 670         

Gly Arg Gly Thr Leu Ala Thr Pro Asp Gly Arg Asn Ala Gly Thr Pro 
        675                 680                 685             

Leu Ala Glu Gly Cys Ser Pro Ser His Asn Met Asp Gln His Gly Pro 
    690                 695                 700                 

Thr Ser Val Leu Lys Ser Val Ser Lys Leu Pro Thr Asp Glu Ile Val 
705                 710                 715                 720 

Gly Gly Val Leu Leu Asn Gln Lys Val Asn Pro Gln Thr Leu Ala Lys 
                725                 730                 735     

Glu Glu Asp Lys Leu Lys Leu Ile Ala Leu Leu Arg Thr Phe Phe Asn 
            740                 745                 750         

Arg Leu His Gly Tyr His Ile Gln Tyr Asn Val Val Ser Arg Glu Thr 
        755                 760                 765             

Leu Ile Asp Ala Gln Lys His Pro Glu Lys His Arg Asp Leu Ile Val 
    770                 775                 780                 

Arg Val Ala Gly Tyr Ser Ala Phe Phe Asn Val Leu Ser Lys Ala Thr 
785                 790                 795                 800 

Gln Asp Asp Ile Ile Gly Arg Thr Glu His Thr Leu 
                805                 810         

<210>   327
<211>   666
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   327
atggaattta tgcttgacac attaaattta gatgagatta aaaagtggtc tgaaattttg   60
ccgctagctg gggtaacttc aaatcccact attgcaaaaa gagagggttc tattaatttt   120
tttgaacgaa tcaaagatgt aagagaattg attggctcta caccctctat tcatgttcag   180
gtgatttctc aagattttga aggcatctta aaggatgctc ataaaattcg aagacaagca   240
ggagatgata tatttatcaa agtacctgtt actccagctg gattacgtgc aataaaggcg   300
ctaaaaaaag agggctacca tatcactgca acagctattt atacagttat tcagggatta   360
ttagctatcg aagcaggagc ggattaccta gctccatatt ataatagaat ggaaaatctg   420
aacattgatt caaattctgt cattcgtcaa ttagctcttg ctattgatag acagaactct   480
cctagtaaga ttttagctgc atcctttaaa aatgtagcac aagtaaataa tgctttagct   540
gcaggtgcgc atgctgttac agcaggagcg gatgtttttg aatcagcttt cgccatgcca   600
tctatccaaa aggcggttga tgatttttct gacgattggt ttgttattca aaatagtcgt   660
tccatt                                                              666

<210>   328
<211>   222
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transaldolase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902277 (e-121)

<400>   328
Met Glu Phe Met Leu Asp Thr Leu Asn Leu Asp Glu Ile Lys Lys Trp 
1               5                   10                  15      

Ser Glu Ile Leu Pro Leu Ala Gly Val Thr Ser Asn Pro Thr Ile Ala 
            20                  25                  30          

Lys Arg Glu Gly Ser Ile Asn Phe Phe Glu Arg Ile Lys Asp Val Arg 
        35                  40                  45              

Glu Leu Ile Gly Ser Thr Pro Ser Ile His Val Gln Val Ile Ser Gln 
    50                  55                  60                  

Asp Phe Glu Gly Ile Leu Lys Asp Ala His Lys Ile Arg Arg Gln Ala 
65                  70                  75                  80  

Gly Asp Asp Ile Phe Ile Lys Val Pro Val Thr Pro Ala Gly Leu Arg 
                85                  90                  95      

Ala Ile Lys Ala Leu Lys Lys Glu Gly Tyr His Ile Thr Ala Thr Ala 
            100                 105                 110         

Ile Tyr Thr Val Ile Gln Gly Leu Leu Ala Ile Glu Ala Gly Ala Asp 
        115                 120                 125             

Tyr Leu Ala Pro Tyr Tyr Asn Arg Met Glu Asn Leu Asn Ile Asp Ser 
    130                 135                 140                 

Asn Ser Val Ile Arg Gln Leu Ala Leu Ala Ile Asp Arg Gln Asn Ser 
145                 150                 155                 160 

Pro Ser Lys Ile Leu Ala Ala Ser Phe Lys Asn Val Ala Gln Val Asn 
                165                 170                 175     

Asn Ala Leu Ala Ala Gly Ala His Ala Val Thr Ala Gly Ala Asp Val 
            180                 185                 190         

Phe Glu Ser Ala Phe Ala Met Pro Ser Ile Gln Lys Ala Val Asp Asp 
        195                 200                 205             

Phe Ser Asp Asp Trp Phe Val Ile Gln Asn Ser Arg Ser Ile 
    210                 215                 220         

<210>   329
<211>   1086
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   329
atgagaattt ttgctagtcc ttctagatat attcaggggg aaaatgcctt gtttgaaaat   60
gccaaatcaa ttttggattt gggaaattgc cctattctat tatgcgatca gttggtttat   120
gatattgttg gaaaacgatt tgaagattac ctacataggt atggtttcca tattgttctg   180
gcgctattta atggtgaagc ttctgacaat gaaatcaatc gagttgttgc cttggctgag   240
aaagaaaatt gtgatagtat tatcggtctt ggtgggggaa agacgattga tagcgcaaaa   300
gctattgcag atttgattga aaagcctgtt attattgctc caacaattgc atcgaccgac   360
gcacctgtat ctgctttatc tgttatttat acagatgaag gtgcatttga tcattatcta   420
ttttattcta aaaatccaga tttagttttg gttgatacaa aagttatttc acaagcccct   480
aagcgtttat tagcgtctgg tattgcagat ggtttagcaa cttgggttga ggcgcgtgcg   540
gttatgcagg caaatggaaa aactatgttg ggacaacagc aaacattggc tggagttgca   600
attgcgaaga aatgtgaaga aacgctgttt gcagatggtt tacaggctat ggcagcttgt   660
gaagctaaag tggtgacacc agcattagaa aatattgttg aagctaatac tttattgagt   720
ggtctaggtt ttgaaagtgg aggattagct gcggcgcatg caattcataa tggttttact   780
gcattgacag gtgacattca tcatttaaca catggtgaaa aagtagctta tggaacttta   840
gtacaactat tattggaaaa tagacctaaa gaagaacttg ataagtatat tgagttttac   900
aaaaaaattg gtatgccaac aactctaaaa gaaatgcatt tggatcaagt tggatatgat   960
gatttaataa aagttggtaa acaagcaact atggagggtg agacaattca tcagatgccg   1020
tttaagattt cgccttcaga tgttgctcaa gctattatcg ctgtagatgc ctatgtaaat   1080
tcaaaa                                                              1086

<210>   330
<211>   362
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycerol dehydrogenase (gldA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902278 (0.E+01)

<400>   330
Met Arg Ile Phe Ala Ser Pro Ser Arg Tyr Ile Gln Gly Glu Asn Ala 
1               5                   10                  15      

Leu Phe Glu Asn Ala Lys Ser Ile Leu Asp Leu Gly Asn Cys Pro Ile 
            20                  25                  30          

Leu Leu Cys Asp Gln Leu Val Tyr Asp Ile Val Gly Lys Arg Phe Glu 
        35                  40                  45              

Asp Tyr Leu His Arg Tyr Gly Phe His Ile Val Leu Ala Leu Phe Asn 
    50                  55                  60                  

Gly Glu Ala Ser Asp Asn Glu Ile Asn Arg Val Val Ala Leu Ala Glu 
65                  70                  75                  80  

Lys Glu Asn Cys Asp Ser Ile Ile Gly Leu Gly Gly Gly Lys Thr Ile 
                85                  90                  95      

Asp Ser Ala Lys Ala Ile Ala Asp Leu Ile Glu Lys Pro Val Ile Ile 
            100                 105                 110         

Ala Pro Thr Ile Ala Ser Thr Asp Ala Pro Val Ser Ala Leu Ser Val 
        115                 120                 125             

Ile Tyr Thr Asp Glu Gly Ala Phe Asp His Tyr Leu Phe Tyr Ser Lys 
    130                 135                 140                 

Asn Pro Asp Leu Val Leu Val Asp Thr Lys Val Ile Ser Gln Ala Pro 
145                 150                 155                 160 

Lys Arg Leu Leu Ala Ser Gly Ile Ala Asp Gly Leu Ala Thr Trp Val 
                165                 170                 175     

Glu Ala Arg Ala Val Met Gln Ala Asn Gly Lys Thr Met Leu Gly Gln 
            180                 185                 190         

Gln Gln Thr Leu Ala Gly Val Ala Ile Ala Lys Lys Cys Glu Glu Thr 
        195                 200                 205             

Leu Phe Ala Asp Gly Leu Gln Ala Met Ala Ala Cys Glu Ala Lys Val 
    210                 215                 220                 

Val Thr Pro Ala Leu Glu Asn Ile Val Glu Ala Asn Thr Leu Leu Ser 
225                 230                 235                 240 

Gly Leu Gly Phe Glu Ser Gly Gly Leu Ala Ala Ala His Ala Ile His 
                245                 250                 255     

Asn Gly Phe Thr Ala Leu Thr Gly Asp Ile His His Leu Thr His Gly 
            260                 265                 270         

Glu Lys Val Ala Tyr Gly Thr Leu Val Gln Leu Leu Leu Glu Asn Arg 
        275                 280                 285             

Pro Lys Glu Glu Leu Asp Lys Tyr Ile Glu Phe Tyr Lys Lys Ile Gly 
    290                 295                 300                 

Met Pro Thr Thr Leu Lys Glu Met His Leu Asp Gln Val Gly Tyr Asp 
305                 310                 315                 320 

Asp Leu Ile Lys Val Gly Lys Gln Ala Thr Met Glu Gly Glu Thr Ile 
                325                 330                 335     

His Gln Met Pro Phe Lys Ile Ser Pro Ser Asp Val Ala Gln Ala Ile 
            340                 345                 350         

Ile Ala Val Asp Ala Tyr Val Asn Ser Lys 
        355                 360         

<210>   331
<211>   2499
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   331
atgagttttt acaatcataa agaaattgag cctaagtggc agggctactg ggcagaacat   60
catacattta agacaggaac agatacatca aaacctaagt tttatgcgct tgatatgttc   120
ccttatccgt ctggagctgg tctgcacgta ggacacccag aaggttatac tgcaaccgat   180
atcctcagtc gttacaaacg tgcgcaaggc tacaatgtcc ttcacccaat gggttgggat   240
gcttttggtt tgcctgcaga gcaatacgct atggatactg gtaatgaccc agcagaattt   300
acagcggaaa acattgccaa cttcaaacgt caaattaatg cgcttggatt ttcttatgac   360
tgggatcgtg aagtcaacac aacagatcca aactactaca agtggactca atggattttc   420
accaagcttt acgaaaaagg cttggcctat gaagctgaag tgccagtaaa ctgggttgag   480
gaattgggaa ctgccattgc caatgaagaa gtgcttcctg acggaacttc tgagcgtgga   540
ggctatccag ttgtccgcaa accaatgcgc caatggatgc tcaaaatcac ggcttacgca   600
gagcgcttgc tcaatgactt agatgaacta gattggtcag agtctatcaa ggatatgcaa   660
cgcaactgga ttggtaaatc aactggtgcc aatgtaactt tcaaagtaaa aggaacagac   720
aaggaattta cagtctttac tactcgtccg gacacacttt tcggtgcgac tttcactgtc   780
ttggctcctg aacatgaatt agtagacgct atcacaagtt cagagcaagc agaagctgta   840
gcagactata aacaccaagc cagccttaag tctgacttgg ctcgtacaga ccttgctaaa   900
gaaaaaacag gggtttggac tggtgcttat gccatcaacc ctgtcaatgg taaggaaatg   960
ccaatctgga ttgcagacta tgtccttgct agttatggaa caggtgcggt tatggctgtg   1020
cctgcccacg accaacgtga ctgggaattt gccaaacaat ttgaccttcc aatcgtcgaa   1080
gtacttgaag gtggaaatgt cgaagaagct gcctacacag aggatggcct gcatgtcaat   1140
tcagacttcc tagatggatt gaacaaagaa gacgctattg ccaagattgt ggcttggttg   1200
gaagaaaaag gctgtggtca ggagaaggtt acctaccgtc tccgcgactg gctctttagc   1260
cgtcaacgtt actggggtga gccaattcca atcattcatt gggaagatgg aacttcaaca   1320
gctgttcctg aaactgaatt gccgcttgtc ttgcctgtaa ccaaggatat ccgtccttca   1380
ggtactggtg aaagtccact agctaacttg acagattggc ttgaagtgac tcgtgaagat   1440
ggtgtcaaag gtcgtcgtga aaccaacact atgccacaat gggctggttc aagctggtac   1500
tacctccgct atattgaccc gcacaatact gagaaattgg ctgatgagga cctcctcaaa   1560
caatggttgc cagtagatat ctacgtgggt ggtgcggaac atgctgtact tcacttgctt   1620
tatgctcgtt tctggcataa attcctctat gacctcggtg ttgttccgac taaggaacca   1680
ttccaaaaac tctttaacca agggatgatt ttgggaacaa gctaccgtga ccaccgtggt   1740
gctcttgtgg caaccgacaa ggttgaaaaa cgtgatggtt ccttcttcca tgtagaaaca   1800
ggggaagagt tggagcaagc gccagccaag atgtctaaat cgctcaagaa cgttgttaac   1860
ccagacgatg tggtggaaca atacggtgcc gatacccttc gtgtttatga aatgtttatg   1920
ggaccactcg atgcttcgat tgcttggtca gaagaaggtt tggaaggaag ccgtaagttc   1980
cttgaccgag tttaccgttt gattacaagt aaagaaatcc ttgcggaaaa caatggtgct   2040
cttgacaagg tttacaacga aacagtcaaa gctgttactg agcaaattga gtctctcaaa   2100
ttcaacacag ctattgccca acttatggtc tttgtcaatg ctgctaacaa ggaagataag   2160
ctttatgttg actatgccaa aggctttatt caattgattg caccatttgc acctcacttg   2220
gcagaagaac tctggcaaac agtcgcagaa acaggtgagt caatctctta tgtagcttgg   2280
ccaacttggg acgaaagcaa attggttgaa gatgaaattg aaattgtcgt ccaaatcaaa   2340
ggaaaagttc gtgccaaact catggttgct aaagatctat cacgtgaaga attacaagaa   2400
atcgctttag ctgatgaaaa agtcaaagca gaaattgacg gtaaggaaat cgtgaaagta   2460
attgcggtac cgaataaact cgttaatatc gtcgttaaa                          2499

<210>   332
<211>   833
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   leucyl-tRNA synthetase (leuS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902279 (0.E+01)

<400>   332
Met Ser Phe Tyr Asn His Lys Glu Ile Glu Pro Lys Trp Gln Gly Tyr 
1               5                   10                  15      

Trp Ala Glu His His Thr Phe Lys Thr Gly Thr Asp Thr Ser Lys Pro 
            20                  25                  30          

Lys Phe Tyr Ala Leu Asp Met Phe Pro Tyr Pro Ser Gly Ala Gly Leu 
        35                  40                  45              

His Val Gly His Pro Glu Gly Tyr Thr Ala Thr Asp Ile Leu Ser Arg 
    50                  55                  60                  

Tyr Lys Arg Ala Gln Gly Tyr Asn Val Leu His Pro Met Gly Trp Asp 
65                  70                  75                  80  

Ala Phe Gly Leu Pro Ala Glu Gln Tyr Ala Met Asp Thr Gly Asn Asp 
                85                  90                  95      

Pro Ala Glu Phe Thr Ala Glu Asn Ile Ala Asn Phe Lys Arg Gln Ile 
            100                 105                 110         

Asn Ala Leu Gly Phe Ser Tyr Asp Trp Asp Arg Glu Val Asn Thr Thr 
        115                 120                 125             

Asp Pro Asn Tyr Tyr Lys Trp Thr Gln Trp Ile Phe Thr Lys Leu Tyr 
    130                 135                 140                 

Glu Lys Gly Leu Ala Tyr Glu Ala Glu Val Pro Val Asn Trp Val Glu 
145                 150                 155                 160 

Glu Leu Gly Thr Ala Ile Ala Asn Glu Glu Val Leu Pro Asp Gly Thr 
                165                 170                 175     

Ser Glu Arg Gly Gly Tyr Pro Val Val Arg Lys Pro Met Arg Gln Trp 
            180                 185                 190         

Met Leu Lys Ile Thr Ala Tyr Ala Glu Arg Leu Leu Asn Asp Leu Asp 
        195                 200                 205             

Glu Leu Asp Trp Ser Glu Ser Ile Lys Asp Met Gln Arg Asn Trp Ile 
    210                 215                 220                 

Gly Lys Ser Thr Gly Ala Asn Val Thr Phe Lys Val Lys Gly Thr Asp 
225                 230                 235                 240 

Lys Glu Phe Thr Val Phe Thr Thr Arg Pro Asp Thr Leu Phe Gly Ala 
                245                 250                 255     

Thr Phe Thr Val Leu Ala Pro Glu His Glu Leu Val Asp Ala Ile Thr 
            260                 265                 270         

Ser Ser Glu Gln Ala Glu Ala Val Ala Asp Tyr Lys His Gln Ala Ser 
        275                 280                 285             

Leu Lys Ser Asp Leu Ala Arg Thr Asp Leu Ala Lys Glu Lys Thr Gly 
    290                 295                 300                 

Val Trp Thr Gly Ala Tyr Ala Ile Asn Pro Val Asn Gly Lys Glu Met 
305                 310                 315                 320 

Pro Ile Trp Ile Ala Asp Tyr Val Leu Ala Ser Tyr Gly Thr Gly Ala 
                325                 330                 335     

Val Met Ala Val Pro Ala His Asp Gln Arg Asp Trp Glu Phe Ala Lys 
            340                 345                 350         

Gln Phe Asp Leu Pro Ile Val Glu Val Leu Glu Gly Gly Asn Val Glu 
        355                 360                 365             

Glu Ala Ala Tyr Thr Glu Asp Gly Leu His Val Asn Ser Asp Phe Leu 
    370                 375                 380                 

Asp Gly Leu Asn Lys Glu Asp Ala Ile Ala Lys Ile Val Ala Trp Leu 
385                 390                 395                 400 

Glu Glu Lys Gly Cys Gly Gln Glu Lys Val Thr Tyr Arg Leu Arg Asp 
                405                 410                 415     

Trp Leu Phe Ser Arg Gln Arg Tyr Trp Gly Glu Pro Ile Pro Ile Ile 
            420                 425                 430         

His Trp Glu Asp Gly Thr Ser Thr Ala Val Pro Glu Thr Glu Leu Pro 
        435                 440                 445             

Leu Val Leu Pro Val Thr Lys Asp Ile Arg Pro Ser Gly Thr Gly Glu 
    450                 455                 460                 

Ser Pro Leu Ala Asn Leu Thr Asp Trp Leu Glu Val Thr Arg Glu Asp 
465                 470                 475                 480 

Gly Val Lys Gly Arg Arg Glu Thr Asn Thr Met Pro Gln Trp Ala Gly 
                485                 490                 495     

Ser Ser Trp Tyr Tyr Leu Arg Tyr Ile Asp Pro His Asn Thr Glu Lys 
            500                 505                 510         

Leu Ala Asp Glu Asp Leu Leu Lys Gln Trp Leu Pro Val Asp Ile Tyr 
        515                 520                 525             

Val Gly Gly Ala Glu His Ala Val Leu His Leu Leu Tyr Ala Arg Phe 
    530                 535                 540                 

Trp His Lys Phe Leu Tyr Asp Leu Gly Val Val Pro Thr Lys Glu Pro 
545                 550                 555                 560 

Phe Gln Lys Leu Phe Asn Gln Gly Met Ile Leu Gly Thr Ser Tyr Arg 
                565                 570                 575     

Asp His Arg Gly Ala Leu Val Ala Thr Asp Lys Val Glu Lys Arg Asp 
            580                 585                 590         

Gly Ser Phe Phe His Val Glu Thr Gly Glu Glu Leu Glu Gln Ala Pro 
        595                 600                 605             

Ala Lys Met Ser Lys Ser Leu Lys Asn Val Val Asn Pro Asp Asp Val 
    610                 615                 620                 

Val Glu Gln Tyr Gly Ala Asp Thr Leu Arg Val Tyr Glu Met Phe Met 
625                 630                 635                 640 

Gly Pro Leu Asp Ala Ser Ile Ala Trp Ser Glu Glu Gly Leu Glu Gly 
                645                 650                 655     

Ser Arg Lys Phe Leu Asp Arg Val Tyr Arg Leu Ile Thr Ser Lys Glu 
            660                 665                 670         

Ile Leu Ala Glu Asn Asn Gly Ala Leu Asp Lys Val Tyr Asn Glu Thr 
        675                 680                 685             

Val Lys Ala Val Thr Glu Gln Ile Glu Ser Leu Lys Phe Asn Thr Ala 
    690                 695                 700                 

Ile Ala Gln Leu Met Val Phe Val Asn Ala Ala Asn Lys Glu Asp Lys 
705                 710                 715                 720 

Leu Tyr Val Asp Tyr Ala Lys Gly Phe Ile Gln Leu Ile Ala Pro Phe 
                725                 730                 735     

Ala Pro His Leu Ala Glu Glu Leu Trp Gln Thr Val Ala Glu Thr Gly 
            740                 745                 750         

Glu Ser Ile Ser Tyr Val Ala Trp Pro Thr Trp Asp Glu Ser Lys Leu 
        755                 760                 765             

Val Glu Asp Glu Ile Glu Ile Val Val Gln Ile Lys Gly Lys Val Arg 
    770                 775                 780                 

Ala Lys Leu Met Val Ala Lys Asp Leu Ser Arg Glu Glu Leu Gln Glu 
785                 790                 795                 800 

Ile Ala Leu Ala Asp Glu Lys Val Lys Ala Glu Ile Asp Gly Lys Glu 
                805                 810                 815     

Ile Val Lys Val Ile Ala Val Pro Asn Lys Leu Val Asn Ile Val Val 
            820                 825                 830         

Lys 
    

<210>   333
<211>   693
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   333
atgccagtaa atgaatatgg tcaaatgatt ggggagtcaa tggaagctta tactccaggt   60
gaattgcctt cttttgattt cttagaaggg cgttatgcta ggatagaggc tctttcagtg   120
gaaaagcatg cggaggattt attagctgtt tatggccctg atacgcctcg ggagatgtgg   180
acctacctct ttcaggagtc agtagcagac atggaggaac tggtcagcct tttaaatcag   240
atgttggctc gtaaggaccg tttttattat gcaatcatag acaaggcaac tggtaaggct   300
ttgggaactt tttccctcat gcgaattgat cagaataacc gagtaataga agtgggagct   360
gtcacttttt ctccagagct cagggggaca cggataggaa cagaagccca gtatctcttg   420
gcttgctatg tctttgagga gcttaactat cgtcgctatg agtggaaatg cgatgctctt   480
aacctgccat ccagacgagc agcggaacgt ttgggattta tttatgaagg aaccttccgt   540
caggcagtgg tttataaggg gcgtacaaga gatacggatt ggttgtctat gattgataag   600
gactggcctc aagtcaaagc tcgattggaa atatggttgc gtcctgaaaa ctttgataaa   660
aatggacgac agcacaagag cttgagagaa ctt                                693

<210>   334
<211>   231
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902280 (e-126)

<400>   334
Met Pro Val Asn Glu Tyr Gly Gln Met Ile Gly Glu Ser Met Glu Ala 
1               5                   10                  15      

Tyr Thr Pro Gly Glu Leu Pro Ser Phe Asp Phe Leu Glu Gly Arg Tyr 
            20                  25                  30          

Ala Arg Ile Glu Ala Leu Ser Val Glu Lys His Ala Glu Asp Leu Leu 
        35                  40                  45              

Ala Val Tyr Gly Pro Asp Thr Pro Arg Glu Met Trp Thr Tyr Leu Phe 
    50                  55                  60                  

Gln Glu Ser Val Ala Asp Met Glu Glu Leu Val Ser Leu Leu Asn Gln 
65                  70                  75                  80  

Met Leu Ala Arg Lys Asp Arg Phe Tyr Tyr Ala Ile Ile Asp Lys Ala 
                85                  90                  95      

Thr Gly Lys Ala Leu Gly Thr Phe Ser Leu Met Arg Ile Asp Gln Asn 
            100                 105                 110         

Asn Arg Val Ile Glu Val Gly Ala Val Thr Phe Ser Pro Glu Leu Arg 
        115                 120                 125             

Gly Thr Arg Ile Gly Thr Glu Ala Gln Tyr Leu Leu Ala Cys Tyr Val 
    130                 135                 140                 

Phe Glu Glu Leu Asn Tyr Arg Arg Tyr Glu Trp Lys Cys Asp Ala Leu 
145                 150                 155                 160 

Asn Leu Pro Ser Arg Arg Ala Ala Glu Arg Leu Gly Phe Ile Tyr Glu 
                165                 170                 175     

Gly Thr Phe Arg Gln Ala Val Val Tyr Lys Gly Arg Thr Arg Asp Thr 
            180                 185                 190         

Asp Trp Leu Ser Met Ile Asp Lys Asp Trp Pro Gln Val Lys Ala Arg 
        195                 200                 205             

Leu Glu Ile Trp Leu Arg Pro Glu Asn Phe Asp Lys Asn Gly Arg Gln 
    210                 215                 220                 

His Lys Ser Leu Arg Glu Leu 
225                 230     

<210>   335
<211>   414
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   335
atgattacta ttaaaaagca agaaattgtc aagctagagg atgttttgca tctctatcag   60
gctgtcggtt ggacaaacta tacccatcaa acagagatgc tggagcaggc cttatctcat   120
tcattagtaa tttatctggc acttgatggt gatgctgtgg tgggcttgat tcgtttggtt   180
ggagatggtt tttcatcagt ttttgtacag gatttgattg ttttgcctag ctatcagcgt   240
caagggattg gtagctcctt gatgaaagag gctttaggaa attttaaaga ggcctatcaa   300
gtccagctgg cgacagaaga gacagaaaaa aacgtgggat tttatcgttc tatgggcttt   360
gaaatcttat ccacctatga ctgtacagga atgatttgga taaacagaga aaaa         414

<210>   336
<211>   138
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902281 (9.E-67)

<400>   336
Met Ile Thr Ile Lys Lys Gln Glu Ile Val Lys Leu Glu Asp Val Leu 
1               5                   10                  15      

His Leu Tyr Gln Ala Val Gly Trp Thr Asn Tyr Thr His Gln Thr Glu 
            20                  25                  30          


Met Leu Glu Gln Ala Leu Ser His Ser Leu Val Ile Tyr Leu Ala Leu 
        35                  40                  45              

Asp Gly Asp Ala Val Val Gly Leu Ile Arg Leu Val Gly Asp Gly Phe 
    50                  55                  60                  

Ser Ser Val Phe Val Gln Asp Leu Ile Val Leu Pro Ser Tyr Gln Arg 
65                  70                  75                  80  

Gln Gly Ile Gly Ser Ser Leu Met Lys Glu Ala Leu Gly Asn Phe Lys 
                85                  90                  95      

Glu Ala Tyr Gln Val Gln Leu Ala Thr Glu Glu Thr Glu Lys Asn Val 
            100                 105                 110         

Gly Phe Tyr Arg Ser Met Gly Phe Glu Ile Leu Ser Thr Tyr Asp Cys 
        115                 120                 125             

Thr Gly Met Ile Trp Ile Asn Arg Glu Lys 
    130                 135             

<210>   337
<211>   411
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   337
atgtcaaaac tgctagataa gatattatca cgcgaaaata tgctggaagc ctacaatcaa   60
gtaaaatcca ataaaggctc agctgggatt gatggaatga ctatcgaaga gatggataat   120
tatctcagac aaaactggcg cttgactaag gaactgataa aacagagaaa atataagcct   180
caaccagttc ttagagttga gatacctaaa ccagacggag gcatccgtca actaggaatt   240
ccaacagtta tggatagaat gattcaacag gccattgtcc aagtcatgag ccccatttgt   300
gaaccccatt tctcagatac gagttatggt ttcagaccaa ataggtcatg tgaaaaagcc   360
atcatgaagc tcttagaata cttaaatgac ggctatgagt ggatagtgga t            411

<210>   338
<211>   137
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   group II intron, maturase FRAMESHIFT

<400>   338
Met Ser Lys Leu Leu Asp Lys Ile Leu Ser Arg Glu Asn Met Leu Glu 
1               5                   10                  15      

Ala Tyr Asn Gln Val Lys Ser Asn Lys Gly Ser Ala Gly Ile Asp Gly 
            20                  25                  30          

Met Thr Ile Glu Glu Met Asp Asn Tyr Leu Arg Gln Asn Trp Arg Leu 
        35                  40                  45              

Thr Lys Glu Leu Ile Lys Gln Arg Lys Tyr Lys Pro Gln Pro Val Leu 
    50                  55                  60                  

Arg Val Glu Ile Pro Lys Pro Asp Gly Gly Ile Arg Gln Leu Gly Ile 
65                  70                  75                  80  

Pro Thr Val Met Asp Arg Met Ile Gln Gln Ala Ile Val Gln Val Met 
                85                  90                  95      

Ser Pro Ile Cys Glu Pro His Phe Ser Asp Thr Ser Tyr Gly Phe Arg 
            100                 105                 110         

Pro Asn Arg Ser Cys Glu Lys Ala Ile Met Lys Leu Leu Glu Tyr Leu 
        115                 120                 125             

Asn Asp Gly Tyr Glu Trp Ile Val Asp 
    130                 135         

<210>   339
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   339
gtggatagtg gattagacct agagaaattt ttcgatacag ttcctcaaga tagattgatg   60
tccttagtac ataacattat cgaagacgga gatacggaat ccttgattcg taagtatctt   120
cattcaggtg ttatcattaa tggtcaacgt tataaaacac tagttggtac accacaggga   180
ggaaatttat ctcctctctt atccaatatc atgcttaatg aattggacaa ggaattagaa   240
aagaggggac ttcgatttgt gcgctacgca gatgattgtg tgattacggt cggaagcgag   300
gcagcctcta agcgtgtgat gtattcagtc agtcgtttta ttgagaaacg gctaggtttg   360
aaagtaaaca tgaccaagag agttgaaata tctaggtttt gggttctgga aattatcaga   420
tggttggaaa agccgtccac atcaaga                                       447

<210>   340
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   maturase-related protein

<400>   340
Met Asp Ser Gly Leu Asp Leu Glu Lys Phe Phe Asp Thr Val Pro Gln 
1               5                   10                  15      

Asp Arg Leu Met Ser Leu Val His Asn Ile Ile Glu Asp Gly Asp Thr 
            20                  25                  30          

Glu Ser Leu Ile Arg Lys Tyr Leu His Ser Gly Val Ile Ile Asn Gly 
        35                  40                  45              

Gln Arg Tyr Lys Thr Leu Val Gly Thr Pro Gln Gly Gly Asn Leu Ser 
    50                  55                  60                  

Pro Leu Leu Ser Asn Ile Met Leu Asn Glu Leu Asp Lys Glu Leu Glu 
65                  70                  75                  80  

Lys Arg Gly Leu Arg Phe Val Arg Tyr Ala Asp Asp Cys Val Ile Thr 
                85                  90                  95      

Val Gly Ser Glu Ala Ala Ser Lys Arg Val Met Tyr Ser Val Ser Arg 
            100                 105                 110         

Phe Ile Glu Lys Arg Leu Gly Leu Lys Val Asn Met Thr Lys Arg Val 
        115                 120                 125             

Glu Ile Ser Arg Phe Trp Val Leu Glu Ile Ile Arg Trp Leu Glu Lys 
    130                 135                 140                 

Pro Ser Thr Ser Arg 
145                 

<210>   341
<211>   384
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   341
ttgaagaaac taacacagag gaaatggagt atagacctaa caagacgtat tgagcaactg   60
aatttgtcta ttcgaggatg gataaactat tgctcattgg gaaatatgaa aagtatagtc   120
gccagcatag atgagcgctt gcgtactcgc ctacgagtga ttatctggaa gcaatggaag   180
aagaaatcga gacgattatg gggattgctt aagttaggag ttcctaaatg gatagcagat   240
aaggtatctg gctggggcga ccattatcaa ttagtagctc agaagtcggt acttaaacgt   300
gctatatcaa aaccagtcct ggaaaaacgt ggactggttt cgtgtttgga ttattacctt   360
gaacgacatg cgttaaaagt tagt                                          384

<210>   342
<211>   128
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   maturase-related protein-related

<400>   342
Met Lys Lys Leu Thr Gln Arg Lys Trp Ser Ile Asp Leu Thr Arg Arg 
1               5                   10                  15      

Ile Glu Gln Leu Asn Leu Ser Ile Arg Gly Trp Ile Asn Tyr Cys Ser 
            20                  25                  30          

Leu Gly Asn Met Lys Ser Ile Val Ala Ser Ile Asp Glu Arg Leu Arg 
        35                  40                  45              

Thr Arg Leu Arg Val Ile Ile Trp Lys Gln Trp Lys Lys Lys Ser Arg 
    50                  55                  60                  

Arg Leu Trp Gly Leu Leu Lys Leu Gly Val Pro Lys Trp Ile Ala Asp 
65                  70                  75                  80  

Lys Val Ser Gly Trp Gly Asp His Tyr Gln Leu Val Ala Gln Lys Ser 
                85                  90                  95      

Val Leu Lys Arg Ala Ile Ser Lys Pro Val Leu Glu Lys Arg Gly Leu 
            100                 105                 110         

Val Ser Cys Leu Asp Tyr Tyr Leu Glu Arg His Ala Leu Lys Val Ser 
        115                 120                 125             


<210>   343
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   343
atgatggaat tagtactcaa aactattatc ggaccaattg tggtcggtgt cgttcttcgt   60
atagtcgata aatggctaaa caaggacaaa                                    90

<210>   344
<211>   30

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   344
Met Met Glu Leu Val Leu Lys Thr Ile Ile Gly Pro Ile Val Val Gly 
1               5                   10                  15      

Val Val Leu Arg Ile Val Asp Lys Trp Leu Asn Lys Asp Lys 
            20                  25                  30  

<210>   345
<211>   996
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   345
atgagtagaa ttttagataa tgagatgatg ggtgatgagg agttagtaga acgcacgctc   60
cgtcctcagt atttacgtga atatattggt caggataagg ttaaggatca acttcagatc   120
tttatcgaag ccgctaaaat gcgggatgaa gcgctggatc atgtgctctt atttggccct   180
ccagggcttg ggaaaacaac catggctttt gtcattgcca atgaactggg agtcaatctc   240
aagcaaacgt ctggtcctgt tatcgaaaaa gcgggtgatt tggtagcgat tttgaatgat   300
ttagagcctg gagatgtcct ctttattgac gagattcatc gcttacccat gtcagtggaa   360
gaagtgcttt atagtgccat ggaggacttc tacatcgata ttatgattgg ggctggtgaa   420
ggcagtcgca gtgttcattt ggagttgcct ccttttacct tgattggtgc gacgactcgg   480

gctggtatgc tctcaaatcc actacgggca cgttttggga ttacaggtca tatggagtat   540
tatgctcatg ctgacttgac agaaattgtc gagcggacgg cagatatttt tgagatggaa   600
atcacccatg aggcagcatc tgagttggcc ctacgtagtc gtggaacccc tcgtattgcc   660
aatcgtctcc tcaagcgcgt gcgcgatttt gcccagataa tggggaatgg ggttatcgat   720
gatgttatta ccgataaggc tttgactatg ctggatgttg accatgaagg tttggactat   780
gtggatcaaa aaatccttcg caccatgatt gagatgtaca gtggaggacc tgttggtcta   840
ggaactcttt ctgtgaatat cgccgaagag cgtgagacag ttgaagacat gtatgagcct   900
tacttgattc aaaaaggttt tatcatgcgg acacggtctg gacgggtggc gactgctaag   960
gcatatgagc acttaggtta tgaatacagt gaaaaa                             996

<210>   346
<211>   332
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Holliday junction DNA helicase RuvB (ruvB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902282 (0.E+01)

<400>   346
Met Ser Arg Ile Leu Asp Asn Glu Met Met Gly Asp Glu Glu Leu Val 
1               5                   10                  15      

Glu Arg Thr Leu Arg Pro Gln Tyr Leu Arg Glu Tyr Ile Gly Gln Asp 
            20                  25                  30          

Lys Val Lys Asp Gln Leu Gln Ile Phe Ile Glu Ala Ala Lys Met Arg 
        35                  40                  45              

Asp Glu Ala Leu Asp His Val Leu Leu Phe Gly Pro Pro Gly Leu Gly 
    50                  55                  60                  

Lys Thr Thr Met Ala Phe Val Ile Ala Asn Glu Leu Gly Val Asn Leu 
65                  70                  75                  80  

Lys Gln Thr Ser Gly Pro Val Ile Glu Lys Ala Gly Asp Leu Val Ala 
                85                  90                  95      

Ile Leu Asn Asp Leu Glu Pro Gly Asp Val Leu Phe Ile Asp Glu Ile 
            100                 105                 110         

His Arg Leu Pro Met Ser Val Glu Glu Val Leu Tyr Ser Ala Met Glu 
        115                 120                 125             

Asp Phe Tyr Ile Asp Ile Met Ile Gly Ala Gly Glu Gly Ser Arg Ser 
    130                 135                 140                 

Val His Leu Glu Leu Pro Pro Phe Thr Leu Ile Gly Ala Thr Thr Arg 
145                 150                 155                 160 

Ala Gly Met Leu Ser Asn Pro Leu Arg Ala Arg Phe Gly Ile Thr Gly 
                165                 170                 175     

His Met Glu Tyr Tyr Ala His Ala Asp Leu Thr Glu Ile Val Glu Arg 
            180                 185                 190         

Thr Ala Asp Ile Phe Glu Met Glu Ile Thr His Glu Ala Ala Ser Glu 
        195                 200                 205             

Leu Ala Leu Arg Ser Arg Gly Thr Pro Arg Ile Ala Asn Arg Leu Leu 
    210                 215                 220                 

Lys Arg Val Arg Asp Phe Ala Gln Ile Met Gly Asn Gly Val Ile Asp 
225                 230                 235                 240 


Asp Val Ile Thr Asp Lys Ala Leu Thr Met Leu Asp Val Asp His Glu 
                245                 250                 255     

Gly Leu Asp Tyr Val Asp Gln Lys Ile Leu Arg Thr Met Ile Glu Met 
            260                 265                 270         

Tyr Ser Gly Gly Pro Val Gly Leu Gly Thr Leu Ser Val Asn Ile Ala 
        275                 280                 285             

Glu Glu Arg Glu Thr Val Glu Asp Met Tyr Glu Pro Tyr Leu Ile Gln 
    290                 295                 300                 

Lys Gly Phe Ile Met Arg Thr Arg Ser Gly Arg Val Ala Thr Ala Lys 
305                 310                 315                 320 

Ala Tyr Glu His Leu Gly Tyr Glu Tyr Ser Glu Lys 
                325                 330         

<210>   347
<211>   570
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   347
atgaatacag tgaaaaataa gcaagaaatc ttagaggctt ttagagaaag tccagatatg   60
atggccattc tgacgatcat ccgagacctt ggtttgaaag actcgtggtt ggcagcaggt   120
tctgtcagaa atttcatctg gaatcttttg tcagacaaat ccccttttga tcatgaaaca   180
gatatagatg tgattttctt tgatccagat ttttcttatg aggaaacctt attactggag   240
aaaaagctga gagaggattt tcctcagtac cagtgggaat tgaaaaatca ggtctatatg   300
catcagcaca gtcctcacac tgcttcctat accagttctc gtgatgctat gagtaagtat   360
ccagaacggt gtacggcagt tggactgcgc ttgaatgaag aattagattt tgaactctat   420
gtaccttatg gtttggagga tattttgaat tttcaagttc gtccaactcc tcatttctta   480
gaaaatgaag accgaatgga actctatcaa acacgtttat ccaagaaaaa ttggcaggag   540
aaatggaaaa atttgatttt taaaaatact                                    570

<210>   348
<211>   190
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902283 (e-110)

<400>   348
Met Asn Thr Val Lys Asn Lys Gln Glu Ile Leu Glu Ala Phe Arg Glu 
1               5                   10                  15      

Ser Pro Asp Met Met Ala Ile Leu Thr Ile Ile Arg Asp Leu Gly Leu 
            20                  25                  30          

Lys Asp Ser Trp Leu Ala Ala Gly Ser Val Arg Asn Phe Ile Trp Asn 
        35                  40                  45              

Leu Leu Ser Asp Lys Ser Pro Phe Asp His Glu Thr Asp Ile Asp Val 
    50                  55                  60                  

Ile Phe Phe Asp Pro Asp Phe Ser Tyr Glu Glu Thr Leu Leu Leu Glu 
65                  70                  75                  80  

Lys Lys Leu Arg Glu Asp Phe Pro Gln Tyr Gln Trp Glu Leu Lys Asn 
                85                  90                  95      

Gln Val Tyr Met His Gln His Ser Pro His Thr Ala Ser Tyr Thr Ser 
            100                 105                 110         

Ser Arg Asp Ala Met Ser Lys Tyr Pro Glu Arg Cys Thr Ala Val Gly 
        115                 120                 125             

Leu Arg Leu Asn Glu Glu Leu Asp Phe Glu Leu Tyr Val Pro Tyr Gly 
    130                 135                 140                 

Leu Glu Asp Ile Leu Asn Phe Gln Val Arg Pro Thr Pro His Phe Leu 
145                 150                 155                 160 

Glu Asn Glu Asp Arg Met Glu Leu Tyr Gln Thr Arg Leu Ser Lys Lys 
                165                 170                 175     

Asn Trp Gln Glu Lys Trp Lys Asn Leu Ile Phe Lys Asn Thr 
            180                 185                 190 

<210>   349
<211>   774
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   349
ttgaatagga ataagatcat gtttggattt tttaagaaag ataaggctgt ggaagtagag   60
gttccgacac aggttcctgc tcatatcggc atcatcatgg atggcaatgg ccgttgggct   120
aaaaaacgta tgcaaccgcg agtttttgga cataaggcgg gcatggaagc attgcaaacc   180
gtgaccaagg cagccaacaa actgggcgtc aaggttatta cggtctatgc tttttctacg   240
gaaaactgga cccgtccaga tcaggaagtc aagtttatca tgaacttgcc agtagagttt   300
tatgataatt atgtcccgga actacatgcg aataatgtta agattcaaat gattggggag   360
acagaccgcc tgcctaagca aacctttgaa gctttaacca aggctgagga attgactaag   420
aacaacacag gattgattct taattttgct cttaactatg gtggacgtgc tgagattaca   480
caggcgctta agttgatttc ccaggatgtt ttagatgcca aaatcaaccc aggtgacatc   540
acagaggaat tgattggtaa ctatctcttt actcagcatt tgcctaagga cttacgagac   600
ccagacttga ttatccgtac tagtggagaa ttacgtttga gcaatttcct tccatggcag   660
ggagcctata gtgagcttta ttttacggac accttatggc ctgattttga cgaagcggcc   720
ttgcaggaag ctattcttgc ctataatcgt cgtcatcgcc gatttggagg agtt         774

<210>   350
<211>   258
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   undecaprenyl diphosphate synthase (uppS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902284 (e-147)

<400>   350
Met Asn Arg Asn Lys Ile Met Phe Gly Phe Phe Lys Lys Asp Lys Ala 
1               5                   10                  15      

Val Glu Val Glu Val Pro Thr Gln Val Pro Ala His Ile Gly Ile Ile 
            20                  25                  30          

Met Asp Gly Asn Gly Arg Trp Ala Lys Lys Arg Met Gln Pro Arg Val 
        35                  40                  45              

Phe Gly His Lys Ala Gly Met Glu Ala Leu Gln Thr Val Thr Lys Ala 
    50                  55                  60                  

Ala Asn Lys Leu Gly Val Lys Val Ile Thr Val Tyr Ala Phe Ser Thr 
65                  70                  75                  80  

Glu Asn Trp Thr Arg Pro Asp Gln Glu Val Lys Phe Ile Met Asn Leu 
                85                  90                  95      

Pro Val Glu Phe Tyr Asp Asn Tyr Val Pro Glu Leu His Ala Asn Asn 
            100                 105                 110         

Val Lys Ile Gln Met Ile Gly Glu Thr Asp Arg Leu Pro Lys Gln Thr 
        115                 120                 125             

Phe Glu Ala Leu Thr Lys Ala Glu Glu Leu Thr Lys Asn Asn Thr Gly 
    130                 135                 140                 

Leu Ile Leu Asn Phe Ala Leu Asn Tyr Gly Gly Arg Ala Glu Ile Thr 
145                 150                 155                 160 

Gln Ala Leu Lys Leu Ile Ser Gln Asp Val Leu Asp Ala Lys Ile Asn 
                165                 170                 175     

Pro Gly Asp Ile Thr Glu Glu Leu Ile Gly Asn Tyr Leu Phe Thr Gln 
            180                 185                 190         

His Leu Pro Lys Asp Leu Arg Asp Pro Asp Leu Ile Ile Arg Thr Ser 
        195                 200                 205             

Gly Glu Leu Arg Leu Ser Asn Phe Leu Pro Trp Gln Gly Ala Tyr Ser 
    210                 215                 220                 

Glu Leu Tyr Phe Thr Asp Thr Leu Trp Pro Asp Phe Asp Glu Ala Ala 
225                 230                 235                 240 

Leu Gln Glu Ala Ile Leu Ala Tyr Asn Arg Arg His Arg Arg Phe Gly 
                245                 250                 255     

Gly Val 
        

<210>   351
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   351
atgacccagg atttacagaa aagaaccttg tttgcaggga ttgccctggc tattttccta   60
ccaattttaa tgattggggg cctcttgctt cagatagcaa tcggaatcat agccatgcta   120
gccatgcatg aacttttgaa gatgagaggt ctagagacca tgacgatgga gggcctcttg   180
accctctttg caacctttgc attgaccatt cccttggaga attacctgac ttttttgcca   240
gttgatggga atgtggttgc ctatagtgtt ttgatttcaa tcatgttagg aacgaccgtt   300
tttagcaagt cttatacgat tgaggatgcg gttttccctc ttgctatgag cttctacgtg   360
ggctttggat ttaatgcttt actagatgct cgtgttgcag gtttggacaa ggctctctta   420
gccttgtgta tcgtctgggc gacagacagt ggtgcctatc ttgttgggat gaactatggg   480
aaacgaaagt tagcaccaag ggtatcgcct aataaaaccc ttgagggtgc cttgggtggt   540
attttaggag caattttagt aaccattatc cttatgatag ttgacagtac agttgctctt   600
ccatatggaa tttacaagat gtcagtcttt gctattttct ttagcattgc tggacaattt   660
ggtgatttac tagaaagttc gatcaaacgt cattttggtg ttaaggattc tgggaaattt   720
atccctggac atggtggtgt tttggatcgt ttcgatagta tgttgcttgt atttccaatc   780
atgcacttat ttggactctt t                                             801

<210>   352
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphatidate cytidylyltransferase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902285 (e-146)

<400>   352
Met Thr Gln Asp Leu Gln Lys Arg Thr Leu Phe Ala Gly Ile Ala Leu 
1               5                   10                  15      

Ala Ile Phe Leu Pro Ile Leu Met Ile Gly Gly Leu Leu Leu Gln Ile 
            20                  25                  30          

Ala Ile Gly Ile Ile Ala Met Leu Ala Met His Glu Leu Leu Lys Met 
        35                  40                  45              

Arg Gly Leu Glu Thr Met Thr Met Glu Gly Leu Leu Thr Leu Phe Ala 
    50                  55                  60                  

Thr Phe Ala Leu Thr Ile Pro Leu Glu Asn Tyr Leu Thr Phe Leu Pro 
65                  70                  75                  80  

Val Asp Gly Asn Val Val Ala Tyr Ser Val Leu Ile Ser Ile Met Leu 
                85                  90                  95      

Gly Thr Thr Val Phe Ser Lys Ser Tyr Thr Ile Glu Asp Ala Val Phe 
            100                 105                 110         

Pro Leu Ala Met Ser Phe Tyr Val Gly Phe Gly Phe Asn Ala Leu Leu 
        115                 120                 125             

Asp Ala Arg Val Ala Gly Leu Asp Lys Ala Leu Leu Ala Leu Cys Ile 
    130                 135                 140                 

Val Trp Ala Thr Asp Ser Gly Ala Tyr Leu Val Gly Met Asn Tyr Gly 
145                 150                 155                 160 

Lys Arg Lys Leu Ala Pro Arg Val Ser Pro Asn Lys Thr Leu Glu Gly 
                165                 170                 175     

Ala Leu Gly Gly Ile Leu Gly Ala Ile Leu Val Thr Ile Ile Leu Met 
            180                 185                 190         

Ile Val Asp Ser Thr Val Ala Leu Pro Tyr Gly Ile Tyr Lys Met Ser 
        195                 200                 205             

Val Phe Ala Ile Phe Phe Ser Ile Ala Gly Gln Phe Gly Asp Leu Leu 
    210                 215                 220                 

Glu Ser Ser Ile Lys Arg His Phe Gly Val Lys Asp Ser Gly Lys Phe 
225                 230                 235                 240 

Ile Pro Gly His Gly Gly Val Leu Asp Arg Phe Asp Ser Met Leu Leu 
                245                 250                 255     

Val Phe Pro Ile Met His Leu Phe Gly Leu Phe 
            260                 265         

<210>   353
<211>   1257
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   353
atgctcggaa ttttaacctt tattctggtt ttcgggatta ttgtagtggt gcacgagttc   60
ggtcacttct actttgccaa gaaatcaggg attttagtac gtgaatttgc catcggtatg   120
ggacctaaaa tttttgctca cattggcaag gatggaacgg cctataccat tcgaatcttg   180
cctctgggtg gctatgtccg catggccggt tggggtgatg atacaactga aatcaagaca   240
ggaacgcctg ttagtttgac acttgctgat gatggtaagg ttaaacgcat caatctctca   300
ggtaaaaaat tggatcaaac agccctccct atgcaggtga cccagtttga ttttgaagac   360
aagctcttta tcaaaggatt ggttctggaa gaagaaaaaa catttgcagt ggatcacgat   420
gcaacggttg tggaagcaga tggtactgag gttcggattg cacctttaga tgttcaatat   480
caaaatgcga ctatctgggg caaactgatt accaattttg caggtcctat gaacaatttt   540
atcttaggtg tcgttgtttt ttgggtttta atctttatgc agggtggtgt cagagatgtt   600
gataccaatc agttccatat catgccccaa ggtgccttgg ccaaggtagg agtaccagaa   660
atggcacaaa ttaccaagat tggctcacat gaggttagca actgggaaag cttgatccaa   720
gctgtggaaa cagaaaccaa agataagacg gcaccgactt tggatgtgac tatttctgaa   780
aaggggagtg acaaacaagt cactgttaca cccaaagata gtcaaggtcg ttaccttcta   840
ggtgttcaac cgggggttaa gtcagatttt ctatccatgt ttgtaggtgg ttttacaact   900
gctgctgact cagctctccg aattctctca gctctgaaaa atctgatttt ccaaccagat   960
ttgaacaagt tgggtggacc tgttgctatc tttaaggcaa gtagtgatgc tgctaaaaat   1020
ggaattgaaa atatcttgta cttcttggca atgatttcca tcaatattgg gatttttaat   1080
cttattccga ttccagcctt ggatggtggt aagattgtgc tcaatatcct agaagccatc   1140
cgccgcaaac cattgaaaca agaaattgaa acctatgtca ccttggccgg agtggtcatc   1200
atggttgtct tgatgattgc tgtgacttgg aatgacatta tgcgactctt ttttaga      1257

<210>   354
<211>   419
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   eep protein (eep)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902286 (0.E+01)

<400>   354
Met Leu Gly Ile Leu Thr Phe Ile Leu Val Phe Gly Ile Ile Val Val 
1               5                   10                  15      

Val His Glu Phe Gly His Phe Tyr Phe Ala Lys Lys Ser Gly Ile Leu 
            20                  25                  30          

Val Arg Glu Phe Ala Ile Gly Met Gly Pro Lys Ile Phe Ala His Ile 
        35                  40                  45              

Gly Lys Asp Gly Thr Ala Tyr Thr Ile Arg Ile Leu Pro Leu Gly Gly 
    50                  55                  60                  

Tyr Val Arg Met Ala Gly Trp Gly Asp Asp Thr Thr Glu Ile Lys Thr 
65                  70                  75                  80  

Gly Thr Pro Val Ser Leu Thr Leu Ala Asp Asp Gly Lys Val Lys Arg 
                85                  90                  95      

Ile Asn Leu Ser Gly Lys Lys Leu Asp Gln Thr Ala Leu Pro Met Gln 
            100                 105                 110         

Val Thr Gln Phe Asp Phe Glu Asp Lys Leu Phe Ile Lys Gly Leu Val 
        115                 120                 125             

Leu Glu Glu Glu Lys Thr Phe Ala Val Asp His Asp Ala Thr Val Val 
    130                 135                 140                 

Glu Ala Asp Gly Thr Glu Val Arg Ile Ala Pro Leu Asp Val Gln Tyr 
145                 150                 155                 160 

Gln Asn Ala Thr Ile Trp Gly Lys Leu Ile Thr Asn Phe Ala Gly Pro 
                165                 170                 175     

Met Asn Asn Phe Ile Leu Gly Val Val Val Phe Trp Val Leu Ile Phe 
            180                 185                 190         

Met Gln Gly Gly Val Arg Asp Val Asp Thr Asn Gln Phe His Ile Met 
        195                 200                 205             

Pro Gln Gly Ala Leu Ala Lys Val Gly Val Pro Glu Met Ala Gln Ile 
    210                 215                 220                 

Thr Lys Ile Gly Ser His Glu Val Ser Asn Trp Glu Ser Leu Ile Gln 
225                 230                 235                 240 

Ala Val Glu Thr Glu Thr Lys Asp Lys Thr Ala Pro Thr Leu Asp Val 
                245                 250                 255     

Thr Ile Ser Glu Lys Gly Ser Asp Lys Gln Val Thr Val Thr Pro Lys 
            260                 265                 270         

Asp Ser Gln Gly Arg Tyr Leu Leu Gly Val Gln Pro Gly Val Lys Ser 
        275                 280                 285             

Asp Phe Leu Ser Met Phe Val Gly Gly Phe Thr Thr Ala Ala Asp Ser 
    290                 295                 300                 

Ala Leu Arg Ile Leu Ser Ala Leu Lys Asn Leu Ile Phe Gln Pro Asp 
305                 310                 315                 320 

Leu Asn Lys Leu Gly Gly Pro Val Ala Ile Phe Lys Ala Ser Ser Asp 
                325                 330                 335     

Ala Ala Lys Asn Gly Ile Glu Asn Ile Leu Tyr Phe Leu Ala Met Ile 
            340                 345                 350         

Ser Ile Asn Ile Gly Ile Phe Asn Leu Ile Pro Ile Pro Ala Leu Asp 
        355                 360                 365             

Gly Gly Lys Ile Val Leu Asn Ile Leu Glu Ala Ile Arg Arg Lys Pro 
    370                 375                 380                 

Leu Lys Gln Glu Ile Glu Thr Tyr Val Thr Leu Ala Gly Val Val Ile 
385                 390                 395                 400 

Met Val Val Leu Met Ile Ala Val Thr Trp Asn Asp Ile Met Arg Leu 
                405                 410                 415     

Phe Phe Arg 
            

<210>   355
<211>   1851
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   355
atgaaacaaa gtaaaatgcc tatcccaacg cttcgcgaaa tgccaagcga tgctcaagtt   60
atcagccatg ctcttatgtt gcgtgctggt tatgttcgcc aagtttcagc aggtgtttat   120
tcttatctac cacttgccaa ccgtgtgatt gaaaaagcta aaaacatcat gcgccaagaa   180
ttcgaaaaga ttggtgctgt tgagatgttg gctccagccc ttcttagtgc agaattgtgg   240
cgtgaatcag gtcgttacga aacctatggt gaagaccttt acaaactaaa aaaccgtgaa   300
aaatcagact ttatcttagg tccaactcac gaagaaacct ttacagctat tgtccgtgat   360
tctgttaaat cttacaagca attgccactc aacctttatc aaattcagcc caagtatcgt   420
gatgaaaaac gcccgcgtaa tggacttctt cgtacacgtg agtttatcat gaaggatgct   480
tatagtttcc acgctaacta tgatagtttg gatagtgttt atgatgagta caaagcagcc   540
tatgagcgta ttttcactcg tagtggttta gacttcaagg ctattattgg tgacggtgga   600
gccatgggtg gtaaggatag ccaagaattt atggccatta catctgctcg tacagacctt   660
gaccgctggg ttgtcttgga caagtcagtt gcctcatttg acgaaattcc tgcagaagtg   720
caagaagaaa tcaaggcaga attgctcaaa tggatagtct ctggtgaaga taccattgct   780
tactcaagtg agtctagcta tgcagctaac ttagaaatgg caacaaacga gtacaaacca   840
agcaaccgtg ttgtcgctga agaagaagtt actcgtgttg caacgccaga tgttaaatca   900
attgatgaag ttgcagcctt cctcaatgtt ccagaagaac aaacgattaa aaccctcttc   960
tacattgcag atggtgagct tgttgcagcc cttctagttg gaaatgacca actcaacgaa   1020
gtcaagttga aaaatcactt gggagcagat ttctttgacg ttgctagcga agaagaagtg   1080
gcgaatgttg ttcaagcagg atttggttca cttggaccag ttggtttgcc agagaatatt   1140
aaaattattg cagatcgtaa ggtacaagat gttcgcaatg cagttgtcgg tgctaacgaa   1200
gatgactacc acttgactgg tgtgaaccca ggccgtgatt ttactgcaga atatgtggat   1260
atccgtgaag ttcgtgaggg tgaaatttcc ccagatggac aaggtgtcct taactttgcg   1320
cgtggtattg agatcggtca tattttcaaa ctcggaactc gctattcagc aagcatggga   1380
gcagatgtct tggatgaaaa tggtcgtgct gtgccaatca tcatgggatg ttacggtatc   1440
ggtgtcagcc gtcttctttc agcagtgatg gagcaacacg ctcgcctctt tgttaacaaa   1500
acgccaaaag gtgaataccg ttacgcttgg ggaatcaatt tccctaaaga attggcacca   1560
tttgatgtgc atttgattac tgtcaatgtc aaggatgaag aagcgcaagc cttgacagaa   1620
aaacttgaag caagcttgat gggagctggt tatgaagtct tgacagatga ccgtaacgaa   1680
cgtgtcggtg ttaaatttag cgatagtgac ttgattggtc ttccaatccg tatcactgtt   1740
ggtaaaaaag cggccgatgg cattgtagaa gttaagatca aggcaactgg tgacaccatt   1800
gaggttcatg cagataacgt gcttgaaacg cttgaaatcc taagcaagaa a            1851

<210>   356
<211>   617
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   prolyl-tRNA synthetase (proS)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902287 (0.E+01)


<400>   356
Met Lys Gln Ser Lys Met Pro Ile Pro Thr Leu Arg Glu Met Pro Ser 
1               5                   10                  15      

Asp Ala Gln Val Ile Ser His Ala Leu Met Leu Arg Ala Gly Tyr Val 
            20                  25                  30          

Arg Gln Val Ser Ala Gly Val Tyr Ser Tyr Leu Pro Leu Ala Asn Arg 
        35                  40                  45              

Val Ile Glu Lys Ala Lys Asn Ile Met Arg Gln Glu Phe Glu Lys Ile 
    50                  55                  60                  

Gly Ala Val Glu Met Leu Ala Pro Ala Leu Leu Ser Ala Glu Leu Trp 
65                  70                  75                  80  

Arg Glu Ser Gly Arg Tyr Glu Thr Tyr Gly Glu Asp Leu Tyr Lys Leu 
                85                  90                  95      

Lys Asn Arg Glu Lys Ser Asp Phe Ile Leu Gly Pro Thr His Glu Glu 
            100                 105                 110         

Thr Phe Thr Ala Ile Val Arg Asp Ser Val Lys Ser Tyr Lys Gln Leu 
        115                 120                 125             

Pro Leu Asn Leu Tyr Gln Ile Gln Pro Lys Tyr Arg Asp Glu Lys Arg 
    130                 135                 140                 

Pro Arg Asn Gly Leu Leu Arg Thr Arg Glu Phe Ile Met Lys Asp Ala 
145                 150                 155                 160 

Tyr Ser Phe His Ala Asn Tyr Asp Ser Leu Asp Ser Val Tyr Asp Glu 
                165                 170                 175     

Tyr Lys Ala Ala Tyr Glu Arg Ile Phe Thr Arg Ser Gly Leu Asp Phe 
            180                 185                 190         

Lys Ala Ile Ile Gly Asp Gly Gly Ala Met Gly Gly Lys Asp Ser Gln 
        195                 200                 205             

Glu Phe Met Ala Ile Thr Ser Ala Arg Thr Asp Leu Asp Arg Trp Val 
    210                 215                 220                 

Val Leu Asp Lys Ser Val Ala Ser Phe Asp Glu Ile Pro Ala Glu Val 
225                 230                 235                 240 

Gln Glu Glu Ile Lys Ala Glu Leu Leu Lys Trp Ile Val Ser Gly Glu 
                245                 250                 255     

Asp Thr Ile Ala Tyr Ser Ser Glu Ser Ser Tyr Ala Ala Asn Leu Glu 
            260                 265                 270         

Met Ala Thr Asn Glu Tyr Lys Pro Ser Asn Arg Val Val Ala Glu Glu 
        275                 280                 285             

Glu Val Thr Arg Val Ala Thr Pro Asp Val Lys Ser Ile Asp Glu Val 
    290                 295                 300                 

Ala Ala Phe Leu Asn Val Pro Glu Glu Gln Thr Ile Lys Thr Leu Phe 
305                 310                 315                 320 

Tyr Ile Ala Asp Gly Glu Leu Val Ala Ala Leu Leu Val Gly Asn Asp 
                325                 330                 335     

Gln Leu Asn Glu Val Lys Leu Lys Asn His Leu Gly Ala Asp Phe Phe 
            340                 345                 350         

Asp Val Ala Ser Glu Glu Glu Val Ala Asn Val Val Gln Ala Gly Phe 
        355                 360                 365             

Gly Ser Leu Gly Pro Val Gly Leu Pro Glu Asn Ile Lys Ile Ile Ala 
    370                 375                 380                 

Asp Arg Lys Val Gln Asp Val Arg Asn Ala Val Val Gly Ala Asn Glu 
385                 390                 395                 400 

Asp Asp Tyr His Leu Thr Gly Val Asn Pro Gly Arg Asp Phe Thr Ala 
                405                 410                 415     

Glu Tyr Val Asp Ile Arg Glu Val Arg Glu Gly Glu Ile Ser Pro Asp 
            420                 425                 430         

Gly Gln Gly Val Leu Asn Phe Ala Arg Gly Ile Glu Ile Gly His Ile 
        435                 440                 445             

Phe Lys Leu Gly Thr Arg Tyr Ser Ala Ser Met Gly Ala Asp Val Leu 
    450                 455                 460                 

Asp Glu Asn Gly Arg Ala Val Pro Ile Ile Met Gly Cys Tyr Gly Ile 
465                 470                 475                 480 

Gly Val Ser Arg Leu Leu Ser Ala Val Met Glu Gln His Ala Arg Leu 
                485                 490                 495     

Phe Val Asn Lys Thr Pro Lys Gly Glu Tyr Arg Tyr Ala Trp Gly Ile 
            500                 505                 510         

Asn Phe Pro Lys Glu Leu Ala Pro Phe Asp Val His Leu Ile Thr Val 
        515                 520                 525             

Asn Val Lys Asp Glu Glu Ala Gln Ala Leu Thr Glu Lys Leu Glu Ala 
    530                 535                 540                 

Ser Leu Met Gly Ala Gly Tyr Glu Val Leu Thr Asp Asp Arg Asn Glu 
545                 550                 555                 560 

Arg Val Gly Val Lys Phe Ser Asp Ser Asp Leu Ile Gly Leu Pro Ile 
                565                 570                 575     

Arg Ile Thr Val Gly Lys Lys Ala Ala Asp Gly Ile Val Glu Val Lys 
            580                 585                 590         

Ile Lys Ala Thr Gly Asp Thr Ile Glu Val His Ala Asp Asn Val Leu 
        595                 600                 605             

Glu Thr Leu Glu Ile Leu Ser Lys Lys 
    610                 615         

<210>   357
<211>   1377
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   357
atgctaagat ttccaaagga ttttgtctgg ggatcctcta cttctggacc gcagacagaa   60
ggacgtgtag ctggtgacgg taagggagac aatctctggg attactggtt ccaagtggag   120
ccaaatcgtt actataatgg gattggttca gataagacat cgacttttta tgaaaattgg   180
gagcgggata ttgagctttt gttagagact ggtcacacag cctttcggac ttctattcag   240
tggtcacgga tttttccaca aggctgtgga aaagtcaaca ctcaaggtgt ggatttttat   300
cgtaaggtct ttgaggctat taaggctaaa ggaattcgtc tgttagtcaa tctctatcat   360
tttgatttac cttttgccct tcaagaggat ggtgatggtt gggaaaataa ggcgacagtc   420
tcagcctatg aagactatgc tcgtttttgt tttgagactt atggagattt agtggatcaa   480
tggattacct ttaacgagcc catcgttcct gtagaatttg gttattttta tgatgcccat   540
tatccacata aggtggatgc agaggcagct gttaaggtag cctatcatac acaattggcc   600
agcagccggg ctgttaaggc ttgccatgaa cttttgcctg attccaagat tgggattgtc   660
ctcaacttga caccggctta tccacgtagc cagcatcctg ctgatgtcaa ggcagctcgt   720
attgcggccc tttttcaggc ccaatctttc ttagatccat ctgtcttggg gacttatcca   780
caggagttgg tagaaatctt gcatgaacac ggtcttttac ctgatgctac agaggaagag   840
ttggaactca ttcgtgataa tacggtggac ttccttggtg tgaactacta tcaacctttg   900
cgtgttatgg ctcctcgatt tgctaagcat ccagagagtc cactcttacc agaacatttt   960
tacgagcctt atgtgatgcc tggacgtaaa atcaattctc accgtggttg ggagatttat   1020
gagcaaggga tttatgacat cgcccaaaat atcaaggaaa attatggcaa tattgagtgg   1080
atgttgactg agaatggtat gggtgttgaa ggggaagaaa aattccgtca agatggaatg   1140
attcaagatg attaccgtat tgactttgta aaaggtcatc ttcgtgaact tcaccgtgcc   1200
attgaagatg gtgccaactg taagggctac ttgatttgga cctttattga ctgctggtca   1260
tggctcaaca gctataaaaa tcgctatggt ttggtcgaat tagacttgga aacgcaagaa   1320
cgtcgtctga agaaatcagg ccactggttc aaagaattaa gcgataataa tggattt      1377

<210>   358
<211>   459
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl hydrolase, family 1
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902288 (0.E+01)

<400>   358
Met Leu Arg Phe Pro Lys Asp Phe Val Trp Gly Ser Ser Thr Ser Gly 
1               5                   10                  15      

Pro Gln Thr Glu Gly Arg Val Ala Gly Asp Gly Lys Gly Asp Asn Leu 
            20                  25                  30          

Trp Asp Tyr Trp Phe Gln Val Glu Pro Asn Arg Tyr Tyr Asn Gly Ile 
        35                  40                  45              

Gly Ser Asp Lys Thr Ser Thr Phe Tyr Glu Asn Trp Glu Arg Asp Ile 
    50                  55                  60                  

Glu Leu Leu Leu Glu Thr Gly His Thr Ala Phe Arg Thr Ser Ile Gln 
65                  70                  75                  80  

Trp Ser Arg Ile Phe Pro Gln Gly Cys Gly Lys Val Asn Thr Gln Gly 
                85                  90                  95      

Val Asp Phe Tyr Arg Lys Val Phe Glu Ala Ile Lys Ala Lys Gly Ile 
            100                 105                 110         

Arg Leu Leu Val Asn Leu Tyr His Phe Asp Leu Pro Phe Ala Leu Gln 
        115                 120                 125             

Glu Asp Gly Asp Gly Trp Glu Asn Lys Ala Thr Val Ser Ala Tyr Glu 
    130                 135                 140                 

Asp Tyr Ala Arg Phe Cys Phe Glu Thr Tyr Gly Asp Leu Val Asp Gln 
145                 150                 155                 160 

Trp Ile Thr Phe Asn Glu Pro Ile Val Pro Val Glu Phe Gly Tyr Phe 
                165                 170                 175     

Tyr Asp Ala His Tyr Pro His Lys Val Asp Ala Glu Ala Ala Val Lys 
            180                 185                 190         

Val Ala Tyr His Thr Gln Leu Ala Ser Ser Arg Ala Val Lys Ala Cys 
        195                 200                 205             

His Glu Leu Leu Pro Asp Ser Lys Ile Gly Ile Val Leu Asn Leu Thr 
    210                 215                 220                 

Pro Ala Tyr Pro Arg Ser Gln His Pro Ala Asp Val Lys Ala Ala Arg 
225                 230                 235                 240 

Ile Ala Ala Leu Phe Gln Ala Gln Ser Phe Leu Asp Pro Ser Val Leu 
                245                 250                 255     

Gly Thr Tyr Pro Gln Glu Leu Val Glu Ile Leu His Glu His Gly Leu 
            260                 265                 270         

Leu Pro Asp Ala Thr Glu Glu Glu Leu Glu Leu Ile Arg Asp Asn Thr 
        275                 280                 285             

Val Asp Phe Leu Gly Val Asn Tyr Tyr Gln Pro Leu Arg Val Met Ala 
    290                 295                 300                 

Pro Arg Phe Ala Lys His Pro Glu Ser Pro Leu Leu Pro Glu His Phe 
305                 310                 315                 320 

Tyr Glu Pro Tyr Val Met Pro Gly Arg Lys Ile Asn Ser His Arg Gly 
                325                 330                 335     

Trp Glu Ile Tyr Glu Gln Gly Ile Tyr Asp Ile Ala Gln Asn Ile Lys 
            340                 345                 350         

Glu Asn Tyr Gly Asn Ile Glu Trp Met Leu Thr Glu Asn Gly Met Gly 
        355                 360                 365             

Val Glu Gly Glu Glu Lys Phe Arg Gln Asp Gly Met Ile Gln Asp Asp 
    370                 375                 380                 

Tyr Arg Ile Asp Phe Val Lys Gly His Leu Arg Glu Leu His Arg Ala 
385                 390                 395                 400 

Ile Glu Asp Gly Ala Asn Cys Lys Gly Tyr Leu Ile Trp Thr Phe Ile 
                405                 410                 415     

Asp Cys Trp Ser Trp Leu Asn Ser Tyr Lys Asn Arg Tyr Gly Leu Val 
            420                 425                 430         

Glu Leu Asp Leu Glu Thr Gln Glu Arg Arg Leu Lys Lys Ser Gly His 
        435                 440                 445             

Trp Phe Lys Glu Leu Ser Asp Asn Asn Gly Phe 
    450                 455                 

<210>   359
<211>   1806
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   359
atgtgtggaa ttgttggtgt tgttggaaac acaaatgcaa ctgatatttt gattcaaggg   60
cttgaaaagc ttgaataccg tggctatgat tctgcgggaa tttttgtcct agatggtgct   120
gataaccatt tggtgaaggc ggttggtcgt attgcagaat tgtctgccaa gacagctggt   180
gttgagggaa caactggtat cggacatact cgttgggcta ctcacggaaa accaactgag   240
gacaatgctc acccacaccg ctctgagacg gaacgttttg tcttggtgca taatggggtg   300
attgagaact atcttgaaat caaggaagaa taccttgcag gtcaccactt caaggggcag   360
acagatactg aaatagccgt tcatttgatt ggaaaatttg cggaagaaga agggctctca   420
gttcttgaag ccttcaaaaa agcccttcac atcatccgtg gttcttatgc ctttgccttg   480
gttgactcac aagatcctga agtcatctac gtagctaaaa ataaatcacc acttttgatt   540
ggtcttggag aaggctataa catggtctgc tcagacgcca tggctatgat tcgtgaaact   600
aaccaataca tggaaatcca tgaccaagag ttggtaatcg tcaaggctga tagtgtggaa   660
gttcaagact atgatggaaa tcgtcgtgag cgtgctagct acactgctga acttgacttg   720
tcagatatcg gtaagggaac ttacccttac tacatgctca aggaaattga cgagcaacca   780
actgttatgc ggaaactcat ccaagcctac acagatgagg ctggtcaagt tgtcgtagac   840
ccagatatca ttaaggctgt tcaagacgca gaccgcatct acatccttgc agctggaaca   900
tcttaccatg caggatttgc ttctaagaaa atgttggaag aattgacaga tacaccagtt   960
gaacttggaa tctcatctga gtggggctac ggtatgccac ttctcagcaa gaaaccactc   1020
ttcatcttta tcagccaatc tggtgaaaca gcggatagtc gtcaagtttt ggtcaaggct   1080
aatgaaatgg gaattccaag cttaacagtg acaaacgttc caggttcaac cctctcacgt   1140
gaagccaact ataccatgct ccttcacgca ggtcctgaaa ttgccgtggc atcaactaaa   1200
gcctatacag cgcaaatcgc agcccttgcc ttccttgcaa aagcagtcgg agaagcaaat   1260
ggtaatgcta aagcgcaagc ctttgacctg gttcatgaat tgtcaatcgt agctcagtct   1320
atcgaatcaa ctctttcaga gaaagaaacc attgaagtca aggttcgtga acttcttgaa   1380
acaactcgta acgcctttta catcggacgt ggtcaagatt actacgtagc catggaagca   1440
agtctcaaac tcaaagagat ttcttatatc cagtgtgaag gctttgctgc aggagaactc   1500
aagcacggaa ccattgcctt gattgaagaa ggaacgcctg ttttggctct cttgtcagat   1560
ccagttcttg ccaatcatac tcgtggaaat atccaagagg tcgcagcccg tggtgccaaa   1620
gtcctcacta tcgcagaaga gaatgtagcc aaagataccg acgatatcgt ccttacgacc   1680
gtacatccat acctctcacc aatttcaatg gtcgtaccaa cgcaattagt cgcttacttt   1740
gcaaccctcc accgtggcct cgatgtggac aaaccacgta accttgccaa gtcagtaacg   1800
gtagaa                                                              1806

<210>   360
<211>   602
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucosamine--fructose-6-phosphate aminotransferase, isomerizing (glmS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902289 (0.E+01)

<400>   360
Met Cys Gly Ile Val Gly Val Val Gly Asn Thr Asn Ala Thr Asp Ile 
1               5                   10                  15      

Leu Ile Gln Gly Leu Glu Lys Leu Glu Tyr Arg Gly Tyr Asp Ser Ala 
            20                  25                  30          

Gly Ile Phe Val Leu Asp Gly Ala Asp Asn His Leu Val Lys Ala Val 
        35                  40                  45              

Gly Arg Ile Ala Glu Leu Ser Ala Lys Thr Ala Gly Val Glu Gly Thr 
    50                  55                  60                  

Thr Gly Ile Gly His Thr Arg Trp Ala Thr His Gly Lys Pro Thr Glu 
65                  70                  75                  80  

Asp Asn Ala His Pro His Arg Ser Glu Thr Glu Arg Phe Val Leu Val 
                85                  90                  95      

His Asn Gly Val Ile Glu Asn Tyr Leu Glu Ile Lys Glu Glu Tyr Leu 
            100                 105                 110         

Ala Gly His His Phe Lys Gly Gln Thr Asp Thr Glu Ile Ala Val His 
        115                 120                 125             

Leu Ile Gly Lys Phe Ala Glu Glu Glu Gly Leu Ser Val Leu Glu Ala 
    130                 135                 140                 

Phe Lys Lys Ala Leu His Ile Ile Arg Gly Ser Tyr Ala Phe Ala Leu 
145                 150                 155                 160 

Val Asp Ser Gln Asp Pro Glu Val Ile Tyr Val Ala Lys Asn Lys Ser 
                165                 170                 175     

Pro Leu Leu Ile Gly Leu Gly Glu Gly Tyr Asn Met Val Cys Ser Asp 
            180                 185                 190         

Ala Met Ala Met Ile Arg Glu Thr Asn Gln Tyr Met Glu Ile His Asp 
        195                 200                 205             

Gln Glu Leu Val Ile Val Lys Ala Asp Ser Val Glu Val Gln Asp Tyr 
    210                 215                 220                 

Asp Gly Asn Arg Arg Glu Arg Ala Ser Tyr Thr Ala Glu Leu Asp Leu 
225                 230                 235                 240 

Ser Asp Ile Gly Lys Gly Thr Tyr Pro Tyr Tyr Met Leu Lys Glu Ile 
                245                 250                 255     

Asp Glu Gln Pro Thr Val Met Arg Lys Leu Ile Gln Ala Tyr Thr Asp 
            260                 265                 270         

Glu Ala Gly Gln Val Val Val Asp Pro Asp Ile Ile Lys Ala Val Gln 
        275                 280                 285             

Asp Ala Asp Arg Ile Tyr Ile Leu Ala Ala Gly Thr Ser Tyr His Ala 
    290                 295                 300                 

Gly Phe Ala Ser Lys Lys Met Leu Glu Glu Leu Thr Asp Thr Pro Val 
305                 310                 315                 320 

Glu Leu Gly Ile Ser Ser Glu Trp Gly Tyr Gly Met Pro Leu Leu Ser 
                325                 330                 335     

Lys Lys Pro Leu Phe Ile Phe Ile Ser Gln Ser Gly Glu Thr Ala Asp 
            340                 345                 350         

Ser Arg Gln Val Leu Val Lys Ala Asn Glu Met Gly Ile Pro Ser Leu 
        355                 360                 365             

Thr Val Thr Asn Val Pro Gly Ser Thr Leu Ser Arg Glu Ala Asn Tyr 
    370                 375                 380                 

Thr Met Leu Leu His Ala Gly Pro Glu Ile Ala Val Ala Ser Thr Lys 
385                 390                 395                 400 

Ala Tyr Thr Ala Gln Ile Ala Ala Leu Ala Phe Leu Ala Lys Ala Val 
                405                 410                 415     

Gly Glu Ala Asn Gly Asn Ala Lys Ala Gln Ala Phe Asp Leu Val His 
            420                 425                 430         

Glu Leu Ser Ile Val Ala Gln Ser Ile Glu Ser Thr Leu Ser Glu Lys 
        435                 440                 445             

Glu Thr Ile Glu Val Lys Val Arg Glu Leu Leu Glu Thr Thr Arg Asn 
    450                 455                 460                 

Ala Phe Tyr Ile Gly Arg Gly Gln Asp Tyr Tyr Val Ala Met Glu Ala 
465                 470                 475                 480 

Ser Leu Lys Leu Lys Glu Ile Ser Tyr Ile Gln Cys Glu Gly Phe Ala 
                485                 490                 495     

Ala Gly Glu Leu Lys His Gly Thr Ile Ala Leu Ile Glu Glu Gly Thr 
            500                 505                 510         

Pro Val Leu Ala Leu Leu Ser Asp Pro Val Leu Ala Asn His Thr Arg 
        515                 520                 525             

Gly Asn Ile Gln Glu Val Ala Ala Arg Gly Ala Lys Val Leu Thr Ile 
    530                 535                 540                 

Ala Glu Glu Asn Val Ala Lys Asp Thr Asp Asp Ile Val Leu Thr Thr 
545                 550                 555                 560 

Val His Pro Tyr Leu Ser Pro Ile Ser Met Val Val Pro Thr Gln Leu 
                565                 570                 575     

Val Ala Tyr Phe Ala Thr Leu His Arg Gly Leu Asp Val Asp Lys Pro 
            580                 585                 590         

Arg Asn Leu Ala Lys Ser Val Thr Val Glu 
        595                 600         

<210>   361
<211>   1047
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   361
atggtagaat tgggaatttc aacatttggg gaaataacgg agcttgaagg gactggacaa   60
acttacagtc atgctgaacg cattcgccag ttggtggcag agattgagct ggctgacaag   120
gttggtttgg atgtatatgg gattggtgag caccatcggg cggattttgc agtatcagcc   180
ccagagattg ttctggccgc tggggcagtc aataccaaga aaatccgttt gaccagtgca   240
gtcagcattc tgtcaagcat ggacccgatt cgtttgttcc aacagtatgc cactatcgat   300
gctttgtcaa atggacgatc ggagattatg gctggaaggg gctctttcac ggaatctttc   360
cctctgtttg gttatgactt gaaagactac gactctcttt ttgatgagaa attagacttg   420
cttcagttag tcaatgaaaa gaccaagtta gactggcaag gtcgattgac tcaaacgatt   480
gctggtaaag aagtttatcc tcgtccagtt caggacaaat tgcccttgtg gatagctaca   540
ggtggtcatg tcgaatcaac agtgaagatt gctcaggctg gtctaccgat tgtatatgct   600
attattggtg gtaatccacg ttattttaaa aagttgattc aggcttatcg tgagattgga   660
agcgaagcgg gccatgctga caaagacttg aaagtgggag cccattcttg ggggtggatt   720
gcggaagatg gtgagcaggc ggtgaaagat tatttccatc cgactaagca agtggtggat   780
gctatttcca aagaccgtcc gcactggcag gaattgcgtt atgagcaata tttggagcag   840
gtagggccaa atggcgccat gtttgttggc aatccagatc aggtggccga aaaattgatt   900

cgcatgatag aggatttagg attggaccgc ttcatgcttc atctaccgct tggttctatg   960
cctcatgacc aggttctgag agctattgaa ctcttcggaa cacaagttgc acccaaagta   1020
cgagcttatt ttgctatgaa agaggct                                       1047

<210>   362
<211>   349
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902290 (0.E+01)

<400>   362
Met Val Glu Leu Gly Ile Ser Thr Phe Gly Glu Ile Thr Glu Leu Glu 
1               5                   10                  15      

Gly Thr Gly Gln Thr Tyr Ser His Ala Glu Arg Ile Arg Gln Leu Val 
            20                  25                  30          

Ala Glu Ile Glu Leu Ala Asp Lys Val Gly Leu Asp Val Tyr Gly Ile 
        35                  40                  45              

Gly Glu His His Arg Ala Asp Phe Ala Val Ser Ala Pro Glu Ile Val 
    50                  55                  60                  

Leu Ala Ala Gly Ala Val Asn Thr Lys Lys Ile Arg Leu Thr Ser Ala 
65                  70                  75                  80  


Val Ser Ile Leu Ser Ser Met Asp Pro Ile Arg Leu Phe Gln Gln Tyr 
                85                  90                  95      

Ala Thr Ile Asp Ala Leu Ser Asn Gly Arg Ser Glu Ile Met Ala Gly 
            100                 105                 110         

Arg Gly Ser Phe Thr Glu Ser Phe Pro Leu Phe Gly Tyr Asp Leu Lys 
        115                 120                 125             

Asp Tyr Asp Ser Leu Phe Asp Glu Lys Leu Asp Leu Leu Gln Leu Val 
    130                 135                 140                 

Asn Glu Lys Thr Lys Leu Asp Trp Gln Gly Arg Leu Thr Gln Thr Ile 
145                 150                 155                 160 

Ala Gly Lys Glu Val Tyr Pro Arg Pro Val Gln Asp Lys Leu Pro Leu 
                165                 170                 175     

Trp Ile Ala Thr Gly Gly His Val Glu Ser Thr Val Lys Ile Ala Gln 
            180                 185                 190         

Ala Gly Leu Pro Ile Val Tyr Ala Ile Ile Gly Gly Asn Pro Arg Tyr 
        195                 200                 205             

Phe Lys Lys Leu Ile Gln Ala Tyr Arg Glu Ile Gly Ser Glu Ala Gly 
    210                 215                 220                 

His Ala Asp Lys Asp Leu Lys Val Gly Ala His Ser Trp Gly Trp Ile 
225                 230                 235                 240 

Ala Glu Asp Gly Glu Gln Ala Val Lys Asp Tyr Phe His Pro Thr Lys 
                245                 250                 255     

Gln Val Val Asp Ala Ile Ser Lys Asp Arg Pro His Trp Gln Glu Leu 
            260                 265                 270         

Arg Tyr Glu Gln Tyr Leu Glu Gln Val Gly Pro Asn Gly Ala Met Phe 
        275                 280                 285             

Val Gly Asn Pro Asp Gln Val Ala Glu Lys Leu Ile Arg Met Ile Glu 
    290                 295                 300                 

Asp Leu Gly Leu Asp Arg Phe Met Leu His Leu Pro Leu Gly Ser Met 
305                 310                 315                 320 

Pro His Asp Gln Val Leu Arg Ala Ile Glu Leu Phe Gly Thr Gln Val 
                325                 330                 335     

Ala Pro Lys Val Arg Ala Tyr Phe Ala Met Lys Glu Ala 
            340                 345                 

<210>   363
<211>   3840
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   363
atgagaaaaa caccatctca cactgagaaa aaaatggtct acagcatccg ttccctcaaa   60
aatggaactg gttctgtcct tatcggcgca agccttgtct tgcttgccat ggctacacca   120
actatctcat ccgacgaaag tacaccaacc actaacgaac ccaacaacag aaatacaacc   180
acccttgccc aacctcttac tgatacagca gctggctctg gtaagaacga aagtgatatt   240
tcttcacctg gaaatgcaaa cgcttcccta gagaaaacag aagaaaaacc tgctgcaagc   300
ccagccgatc cagcaccaca aactggacaa gatcgttcaa gtgagccaac tacttctact   360
agtccagtaa caactgaaac taaggcagaa gagcccatcg aagataacta cttccgtatc   420
catgtcaaaa aacttcctga agaaaacaag gatgctcaag gactatggac ttgggacgat   480
gttgaaaaac catctgaaaa ctggccaaac ggagctttgt ccttcaagga tgccaagaaa   540
gatgactacg gctattacct agatgtcaaa ttaaagggag aacaagccaa gaaaattagc   600

ttcctcatca acaatacagc tggaaaaaat ctaaccggcg ataaatctgt agaaaaacta   660
gttccaaaaa tgaacgaagc ttggttagac caagattaca aggttttctc ttacgagcca   720
cagcctgcag gaactgttcg cgtcaactac taccgcacag atggcaacta tgacaagaaa   780
tctctctggt actggggaga tgtgaaaaat ccaagtagcg ctcaatggcc tgacggaaca   840
gactttacgg ctacaggcaa atatggccgc tatatcgaca ttcctcttaa tgaagccgca   900
agagaatttg gatttttatt actagatgag agcaaacaag gagacgacgt gaaaatccgt   960
aaagaaaatt ataagttcac agatttgaaa aatcatagcc aaattttcct aaaagacgat   1020

gatgaatcga tttacacaaa tccatactat gtccatgata tccgtatgac aggagcccaa   1080
cacgtaggca cttctagcat tgaaagtagc ttttcaacac ttgtcggtgc taaaaaagaa   1140
gatatcctca aacactccaa catcactaat cacctaggaa acaaggtaac tattaccgat   1200
gttgcaatcg atgaagctgg taagaaagtg acctacagcg gagatttctc tgacacaaaa   1260
catccttata ctgttagcta caattccgac caattcacta ccaaaacaag ctggcgcctg   1320
aaagatgaga catacagcta tgatggcaaa ctgggagctg acctaaaaga agaaggaaaa   1380
caagttgatt tgaccctttg gtcaccaagt gctgataagg tttctgttgt tgtctacgac   1440
aagaatgacc ctgacaaagt agttggaact gtcgctcttg aaaaagggga aagaggaact   1500
tggaaacaaa ctctagacag cacaaacaaa ctcggaatca cagatttcac tggctactat   1560
tatcaatacc aaatcgagcg tcaaggtaaa actgttcttg cactcgatcc ttacgctaaa   1620
tctcttgctg cttggaatag cgacgattcc aagattgacg atgcccataa agtggctaaa   1680
gccgcctttg tagatccagc taaactcgga cctcaagact tgacttatgg taagattcac   1740
aatttcaaga ctcgtgaaga cgccgttatc tacgaagctc atgtgcgtga tttcacttca   1800
gatcctgcca ttgcaaaaga cttgaccaaa ccatttggga cttttgaagc cttcattgaa   1860
aaactagact atctcaaaga cttgggtgta acccatatcc agctccttcc agtcttgtct   1920
tactactttg tcaatgaatt gaaaaaccat gaacgcttgt ctgactacgc ttcaagcaac   1980
agcaactaca actggggata tgaccctcaa aactacttct ccttgactgg tatgtactca   2040
agcgatccta agaatccaga aaaacgaatc gcagaattta aaaacctcat caacgaaatc   2100
cacaaacgtg gtatgggagc tatcctagat gtcgtttata accacacagc caaagtcgat   2160
ctctttgaag atttggaacc aaactactac cactttatgg atgccgatgg cacacctcga   2220
actagctttg gtggtggacg cttggggaca acccaccata tgaccaaacg gctcctaatt   2280
gactctatca aatacctagt tgatacctac aaagtggatg gcttccgttt cgatatgatg   2340
ggagaccatg acgccgcttc tatcgaagaa gcttacaagg ctgcacgcgc cctcaatcca   2400
aacctcatca tgcttggtga aggttggaga acctatgccg gtgatgaaaa catgcctact   2460
aaagctgctg accaagattg gatgaaacat accgatactg tcgctgtctt ttcagatgac   2520
atccgtaaca acctcaaatc tggttatcca aacgaaggtc aacctgcctt tatcacaggt   2580
ggcaagcgtg atgtcaacac catctttaaa aatctcattg ctcaaccaac taactttgaa   2640
gctgacagcc ctggagatgt catccaatac atcgcagccc atgataactt gaccctcttt   2700
gacatcattg cccagtctat caaaaaagac ccaagcaagg ctgagaacta tgctgaaatc   2760
caccgtcgtt tacgacttgg aaatctcatg gtcttgacag ctcaaggaac tccatttatc   2820
cactccggtc aggaatatgg acgtactaaa caattccgtg acccagccta caagactcca   2880
gtagcagagg ataaggttcc aaacaaatct cacttgttgc gtgataagga cggcaaccca   2940
tttgactatc cttacttcat ccatgactct tacgattcta gtgatgcagt caacaagttt   3000
gactggacta aggctacaga tggtaaagct tatcctgaaa atgtcaagag ccgtgactat   3060
atgaaaggtt tgattgccct tcgtcaatct acagatgcct tccgacttaa gagtcttcaa   3120
gatatcaaag accgtgtcca cctcatcact gtcccaggcc aaaatggtgt ggaaaaagag   3180
gatgtagtga ttggctacca aatcactgct ccaaacggcg atatctacgc agtctttgtc   3240
aatgcggatg aaaaagctcg cgaatttaat ttgggaactg cctttgcaca tctaagaaat   3300
gcggaagttt tggcagatga aaaccaagca ggaccagtcg gaattgccaa cccgaaagga   3360
cttgaatgga ctgaaaaagg cttgaaattg aatgccctta cagctactgt tcttcgagtc   3420
tctcaaaatg gaactagcca tgagtcaact gcagaagaga aaccagactc aaccccttcc   3480
aagcctgaac atcaaaatga agcttctcac cctgcacatc aagacccagc tccagaagct   3540
agacctgatt ctactaaacc agatgccaaa gtagctgatg cggaaaataa acctagccaa   3600
gctacagctg attcacaagc tgaacaacca gcacaagaag cacaagcatc atctgtaaaa   3660
gaagcggttc gaaacgaatc ggtagaaaac tctagcaagg aaaatatacc tgcaacccca   3720
gataaacaag ctgaacttcc aaatacagga atcaaaaacg aaaacaaact cctatttgca   3780
ggaatcagcc tccttgcgct ccttggtctc ggtttcttac taaaaaataa aaaagagaac   3840

<210>   364
<211>   1280
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alkaline amylopullulanase, putative
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15902291 (0.E+01)

<400>   364
Met Arg Lys Thr Pro Ser His Thr Glu Lys Lys Met Val Tyr Ser Ile 
1               5                   10                  15      

Arg Ser Leu Lys Asn Gly Thr Gly Ser Val Leu Ile Gly Ala Ser Leu 
            20                  25                  30          

Val Leu Leu Ala Met Ala Thr Pro Thr Ile Ser Ser Asp Glu Ser Thr 
        35                  40                  45              

Pro Thr Thr Asn Glu Pro Asn Asn Arg Asn Thr Thr Thr Leu Ala Gln 
    50                  55                  60                  

Pro Leu Thr Asp Thr Ala Ala Gly Ser Gly Lys Asn Glu Ser Asp Ile 
65                  70                  75                  80  

Ser Ser Pro Gly Asn Ala Asn Ala Ser Leu Glu Lys Thr Glu Glu Lys 
                85                  90                  95      

Pro Ala Ala Ser Pro Ala Asp Pro Ala Pro Gln Thr Gly Gln Asp Arg 
            100                 105                 110         

Ser Ser Glu Pro Thr Thr Ser Thr Ser Pro Val Thr Thr Glu Thr Lys 
        115                 120                 125             

Ala Glu Glu Pro Ile Glu Asp Asn Tyr Phe Arg Ile His Val Lys Lys 
    130                 135                 140                 

Leu Pro Glu Glu Asn Lys Asp Ala Gln Gly Leu Trp Thr Trp Asp Asp 
145                 150                 155                 160 

Val Glu Lys Pro Ser Glu Asn Trp Pro Asn Gly Ala Leu Ser Phe Lys 
                165                 170                 175     

Asp Ala Lys Lys Asp Asp Tyr Gly Tyr Tyr Leu Asp Val Lys Leu Lys 
            180                 185                 190         

Gly Glu Gln Ala Lys Lys Ile Ser Phe Leu Ile Asn Asn Thr Ala Gly 
        195                 200                 205             

Lys Asn Leu Thr Gly Asp Lys Ser Val Glu Lys Leu Val Pro Lys Met 
    210                 215                 220                 

Asn Glu Ala Trp Leu Asp Gln Asp Tyr Lys Val Phe Ser Tyr Glu Pro 
225                 230                 235                 240 

Gln Pro Ala Gly Thr Val Arg Val Asn Tyr Tyr Arg Thr Asp Gly Asn 
                245                 250                 255     

Tyr Asp Lys Lys Ser Leu Trp Tyr Trp Gly Asp Val Lys Asn Pro Ser 
            260                 265                 270         

Ser Ala Gln Trp Pro Asp Gly Thr Asp Phe Thr Ala Thr Gly Lys Tyr 
        275                 280                 285             

Gly Arg Tyr Ile Asp Ile Pro Leu Asn Glu Ala Ala Arg Glu Phe Gly 
    290                 295                 300                 

Phe Leu Leu Leu Asp Glu Ser Lys Gln Gly Asp Asp Val Lys Ile Arg 
305                 310                 315                 320 

Lys Glu Asn Tyr Lys Phe Thr Asp Leu Lys Asn His Ser Gln Ile Phe 
                325                 330                 335     

Leu Lys Asp Asp Asp Glu Ser Ile Tyr Thr Asn Pro Tyr Tyr Val His 
            340                 345                 350         

Asp Ile Arg Met Thr Gly Ala Gln His Val Gly Thr Ser Ser Ile Glu 
        355                 360                 365             

Ser Ser Phe Ser Thr Leu Val Gly Ala Lys Lys Glu Asp Ile Leu Lys 
    370                 375                 380                 

His Ser Asn Ile Thr Asn His Leu Gly Asn Lys Val Thr Ile Thr Asp 
385                 390                 395                 400 

Val Ala Ile Asp Glu Ala Gly Lys Lys Val Thr Tyr Ser Gly Asp Phe 
                405                 410                 415     

Ser Asp Thr Lys His Pro Tyr Thr Val Ser Tyr Asn Ser Asp Gln Phe 
            420                 425                 430         

Thr Thr Lys Thr Ser Trp Arg Leu Lys Asp Glu Thr Tyr Ser Tyr Asp 
        435                 440                 445             

Gly Lys Leu Gly Ala Asp Leu Lys Glu Glu Gly Lys Gln Val Asp Leu 
    450                 455                 460                 

Thr Leu Trp Ser Pro Ser Ala Asp Lys Val Ser Val Val Val Tyr Asp 
465                 470                 475                 480 

Lys Asn Asp Pro Asp Lys Val Val Gly Thr Val Ala Leu Glu Lys Gly 
                485                 490                 495     

Glu Arg Gly Thr Trp Lys Gln Thr Leu Asp Ser Thr Asn Lys Leu Gly 
            500                 505                 510         

Ile Thr Asp Phe Thr Gly Tyr Tyr Tyr Gln Tyr Gln Ile Glu Arg Gln 
        515                 520                 525             

Gly Lys Thr Val Leu Ala Leu Asp Pro Tyr Ala Lys Ser Leu Ala Ala 
    530                 535                 540                 

Trp Asn Ser Asp Asp Ser Lys Ile Asp Asp Ala His Lys Val Ala Lys 
545                 550                 555                 560 

Ala Ala Phe Val Asp Pro Ala Lys Leu Gly Pro Gln Asp Leu Thr Tyr 
                565                 570                 575     

Gly Lys Ile His Asn Phe Lys Thr Arg Glu Asp Ala Val Ile Tyr Glu 
            580                 585                 590         

Ala His Val Arg Asp Phe Thr Ser Asp Pro Ala Ile Ala Lys Asp Leu 
        595                 600                 605             

Thr Lys Pro Phe Gly Thr Phe Glu Ala Phe Ile Glu Lys Leu Asp Tyr 
    610                 615                 620                 

Leu Lys Asp Leu Gly Val Thr His Ile Gln Leu Leu Pro Val Leu Ser 
625                 630                 635                 640 

Tyr Tyr Phe Val Asn Glu Leu Lys Asn His Glu Arg Leu Ser Asp Tyr 
                645                 650                 655     

Ala Ser Ser Asn Ser Asn Tyr Asn Trp Gly Tyr Asp Pro Gln Asn Tyr 
            660                 665                 670         

Phe Ser Leu Thr Gly Met Tyr Ser Ser Asp Pro Lys Asn Pro Glu Lys 
        675                 680                 685             

Arg Ile Ala Glu Phe Lys Asn Leu Ile Asn Glu Ile His Lys Arg Gly 
    690                 695                 700                 

Met Gly Ala Ile Leu Asp Val Val Tyr Asn His Thr Ala Lys Val Asp 
705                 710                 715                 720 

Leu Phe Glu Asp Leu Glu Pro Asn Tyr Tyr His Phe Met Asp Ala Asp 
                725                 730                 735     

Gly Thr Pro Arg Thr Ser Phe Gly Gly Gly Arg Leu Gly Thr Thr His 
            740                 745                 750         

His Met Thr Lys Arg Leu Leu Ile Asp Ser Ile Lys Tyr Leu Val Asp 
        755                 760                 765             

Thr Tyr Lys Val Asp Gly Phe Arg Phe Asp Met Met Gly Asp His Asp 
    770                 775                 780                 

Ala Ala Ser Ile Glu Glu Ala Tyr Lys Ala Ala Arg Ala Leu Asn Pro 
785                 790                 795                 800 

Asn Leu Ile Met Leu Gly Glu Gly Trp Arg Thr Tyr Ala Gly Asp Glu 
                805                 810                 815     

Asn Met Pro Thr Lys Ala Ala Asp Gln Asp Trp Met Lys His Thr Asp 
            820                 825                 830         

Thr Val Ala Val Phe Ser Asp Asp Ile Arg Asn Asn Leu Lys Ser Gly 
        835                 840                 845             

Tyr Pro Asn Glu Gly Gln Pro Ala Phe Ile Thr Gly Gly Lys Arg Asp 
    850                 855                 860                 

Val Asn Thr Ile Phe Lys Asn Leu Ile Ala Gln Pro Thr Asn Phe Glu 
865                 870                 875                 880 

Ala Asp Ser Pro Gly Asp Val Ile Gln Tyr Ile Ala Ala His Asp Asn 
                885                 890                 895     

Leu Thr Leu Phe Asp Ile Ile Ala Gln Ser Ile Lys Lys Asp Pro Ser 
            900                 905                 910         

Lys Ala Glu Asn Tyr Ala Glu Ile His Arg Arg Leu Arg Leu Gly Asn 
        915                 920                 925             

Leu Met Val Leu Thr Ala Gln Gly Thr Pro Phe Ile His Ser Gly Gln 
    930                 935                 940                 

Glu Tyr Gly Arg Thr Lys Gln Phe Arg Asp Pro Ala Tyr Lys Thr Pro 
945                 950                 955                 960 

Val Ala Glu Asp Lys Val Pro Asn Lys Ser His Leu Leu Arg Asp Lys 
                965                 970                 975     

Asp Gly Asn Pro Phe Asp Tyr Pro Tyr Phe Ile His Asp Ser Tyr Asp 
            980                 985                 990         

Ser Ser Asp Ala Val Asn Lys Phe Asp Trp Thr Lys Ala Thr Asp Gly 
        995                 1000                1005            

Lys Ala Tyr Pro Glu Asn Val Lys Ser Arg Asp Tyr Met Lys Gly Leu 
    1010                1015                1020                

Ile Ala Leu Arg Gln Ser Thr Asp Ala Phe Arg Leu Lys Ser Leu Gln 
1025                1030                1035                1040

Asp Ile Lys Asp Arg Val His Leu Ile Thr Val Pro Gly Gln Asn Gly 
                1045                1050                1055    

Val Glu Lys Glu Asp Val Val Ile Gly Tyr Gln Ile Thr Ala Pro Asn 
            1060                1065                1070        

Gly Asp Ile Tyr Ala Val Phe Val Asn Ala Asp Glu Lys Ala Arg Glu 
        1075                1080                1085            

Phe Asn Leu Gly Thr Ala Phe Ala His Leu Arg Asn Ala Glu Val Leu 
    1090                1095                1100                

Ala Asp Glu Asn Gln Ala Gly Pro Val Gly Ile Ala Asn Pro Lys Gly 
1105                1110                1115                1120

Leu Glu Trp Thr Glu Lys Gly Leu Lys Leu Asn Ala Leu Thr Ala Thr 
                1125                1130                1135    

Val Leu Arg Val Ser Gln Asn Gly Thr Ser His Glu Ser Thr Ala Glu 
            1140                1145                1150        

Glu Lys Pro Asp Ser Thr Pro Ser Lys Pro Glu His Gln Asn Glu Ala 
        1155                1160                1165            

Ser His Pro Ala His Gln Asp Pro Ala Pro Glu Ala Arg Pro Asp Ser 
    1170                1175                1180                

Thr Lys Pro Asp Ala Lys Val Ala Asp Ala Glu Asn Lys Pro Ser Gln 
1185                1190                1195                1200

Ala Thr Ala Asp Ser Gln Ala Glu Gln Pro Ala Gln Glu Ala Gln Ala 
                1205                1210                1215    

Ser Ser Val Lys Glu Ala Val Arg Asn Glu Ser Val Glu Asn Ser Ser 
            1220                1225                1230        

Lys Glu Asn Ile Pro Ala Thr Pro Asp Lys Gln Ala Glu Leu Pro Asn 
        1235                1240                1245            

Thr Gly Ile Lys Asn Glu Asn Lys Leu Leu Phe Ala Gly Ile Ser Leu 
    1250                1255                1260                

Leu Ala Leu Leu Gly Leu Gly Phe Leu Leu Lys Asn Lys Lys Glu Asn 
1265                1270                1275                1280


<210>   365
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   365
gtgttctcag ctatttttat tcagaaattg atctctaaca ttaccaataa aaaagaaaaa   60
tatcttgaca agcaagggaa aattttgtta caa                                93

<210>   366
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   366
Met Phe Ser Ala Ile Phe Ile Gln Lys Leu Ile Ser Asn Ile Thr Asn 
1               5                   10                  15      

Lys Lys Glu Lys Tyr Leu Asp Lys Gln Gly Lys Ile Leu Leu Gln 
            20                  25                  30      

<210>   367
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   367
atgttgcaaa agtacacaca gatgatatct gtcaccaagt gtatcatcac caaaaataaa   60
aaaacacagg agaatgtaga tgcctacaat                                    90

<210>   368
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   368
Met Leu Gln Lys Tyr Thr Gln Met Ile Ser Val Thr Lys Cys Ile Ile 
1               5                   10                  15      

Thr Lys Asn Lys Lys Thr Gln Glu Asn Val Asp Ala Tyr Asn 
            20                  25                  30  

<210>   369
<211>   411
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   369
atgcctacaa ttaaccaatt ggttcgcaaa ccgcgtaaat caaaagtaga aaaatctaaa   60
tcaccagctt tgaacgttgg ttacaatagt cataaaaaag ttcaaacaaa cgtttcttca   120
ccacaaaaac gtggtgttgc aactcgtgtt ggaacaatga cacctaaaaa acctaactca   180
gcccttcgta aattcgctcg tgtacgtttg agcaacctta tcgaagttac tgcctacatc   240
ccaggtatcg gacacaactt gcaagagcac agcgtggtgc ttcttcgcgg tggacgtgta   300
aaagaccttc caggggtacg ttaccatatc gtccgtggtg cacttgatac tgcaggtgtt   360
aacgatcgta aacaaggccg ttctaaatac ggtactaaac gtccaaaagc a            411

<210>   370
<211>   137
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S12 (rpsL)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902292 (2.E-75)

<400>   370
Met Pro Thr Ile Asn Gln Leu Val Arg Lys Pro Arg Lys Ser Lys Val 
1               5                   10                  15      

Glu Lys Ser Lys Ser Pro Ala Leu Asn Val Gly Tyr Asn Ser His Lys 
            20                  25                  30          

Lys Val Gln Thr Asn Val Ser Ser Pro Gln Lys Arg Gly Val Ala Thr 
        35                  40                  45              

Arg Val Gly Thr Met Thr Pro Lys Lys Pro Asn Ser Ala Leu Arg Lys 
    50                  55                  60                  

Phe Ala Arg Val Arg Leu Ser Asn Leu Ile Glu Val Thr Ala Tyr Ile 
65                  70                  75                  80  

Pro Gly Ile Gly His Asn Leu Gln Glu His Ser Val Val Leu Leu Arg 
                85                  90                  95      

Gly Gly Arg Val Lys Asp Leu Pro Gly Val Arg Tyr His Ile Val Arg 
            100                 105                 110         

Gly Ala Leu Asp Thr Ala Gly Val Asn Asp Arg Lys Gln Gly Arg Ser 
        115                 120                 125             

Lys Tyr Gly Thr Lys Arg Pro Lys Ala 
    130                 135         

<210>   371
<211>   468
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   371
atgagtcgta aaaatagagc tccaaaacgt gacgtattgc cagatccgct atacaattca   60
caactagtta ctcgtcttat caaccgcgtt atgcttgatg gtaaacgtgg tactgctgct   120
tcaatcgttt acggtgcttt tgagcaaatc aaagaagcta ctggcaacga tgcacttgaa   180
gtatttgaaa cagctatgga aaacatcatg cctgtacttg aagtacgtgc acgtcgtgtt   240
ggtggttcta actaccaagt cccagttaaa gttcgtccag aacgtcgtac aacacttgga   300
cttcgttggt tggtaacaat cgctcgtctt cgtggtgaac acacaatgca agaccgtctt   360
gcaaaagaaa tcttggatgc tgctaacaac actggtgcag cagttaagaa acgtgaagat   420
actcaccgta tggctgaagc taaccgtgca ttcgcacact tccgttgg                468

<210>   372
<211>   156
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S7 (rpsG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902293 (6.E-86)

<400>   372
Met Ser Arg Lys Asn Arg Ala Pro Lys Arg Asp Val Leu Pro Asp Pro 
1               5                   10                  15      

Leu Tyr Asn Ser Gln Leu Val Thr Arg Leu Ile Asn Arg Val Met Leu 
            20                  25                  30          

Asp Gly Lys Arg Gly Thr Ala Ala Ser Ile Val Tyr Gly Ala Phe Glu 
        35                  40                  45              

Gln Ile Lys Glu Ala Thr Gly Asn Asp Ala Leu Glu Val Phe Glu Thr 
    50                  55                  60                  

Ala Met Glu Asn Ile Met Pro Val Leu Glu Val Arg Ala Arg Arg Val 
65                  70                  75                  80  

Gly Gly Ser Asn Tyr Gln Val Pro Val Lys Val Arg Pro Glu Arg Arg 
                85                  90                  95      

Thr Thr Leu Gly Leu Arg Trp Leu Val Thr Ile Ala Arg Leu Arg Gly 
            100                 105                 110         

Glu His Thr Met Gln Asp Arg Leu Ala Lys Glu Ile Leu Asp Ala Ala 
        115                 120                 125             

Asn Asn Thr Gly Ala Ala Val Lys Lys Arg Glu Asp Thr His Arg Met 
    130                 135                 140                 

Ala Glu Ala Asn Arg Ala Phe Ala His Phe Arg Trp 
145                 150                 155     

<210>   373
<211>   2079
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   373
atggcacgcg aattttcact tgaaaaaact cgtaatatcg gtatcatggc tcacgtcgat   60
gccggtaaaa caacaactac tgagcgtatt ctttactaca ctggtaaaat ccacaaaatc   120
ggtgaaactc acgaaggtgc gtcacaaatg gactggatgg agcaagagca agaacgtggt   180
atcacgatca catctgctgc gacgacagct caatggaaca accaccgcgt aaacatcatc   240
gacacaccag gacacgtgga cttcacaatc gaagtacaac gttctcttcg tgtattggat   300
ggtgcggtta ccgttcttga ctcacaatca ggtgttgagc ctcaaactga aacagtttgg   360
cgtcaagcaa ctgagtacgg agttccacgt atcgtatttg ccaacaaaat ggacaaaatc   420
ggtgctgact tcctttactc tgtaagcaca cttcacgatc gtcttcaagc aaatgcacac   480
ccaatccaat tgccaatcgg ttctgaagat gacttccgtg gtatcattga cttgatcaag   540
atgaaagctg aaatctatac taacgacctt ggtacggata tccttgaaga agacatccca   600
gctgaatacc ttgaccaagc tcaagaatac cgtgaaaaat tgattgaagc agttgctgaa   660
actgacgaag aattgatgat gaaatacctc gaaggtgaag aaatcactaa cgaagaattg   720
aaagctggta tccgtaaagc gactatcaac gttgaattct tcccagtatt gtgtggttca   780
gccttcaaaa acaaaggtgt tcaattgatg cttgatgcgg ttatcgacta ccttccaagc   840
ccacttgaca tcccagcaat caaaggtatt aacccagata cagacgctga agaaattcgt   900
ccagcatctg acgaagagcc atttgcagct cttgccttca agatcatgac tgacccattc   960
gtaggtcgtt tgacattctt ccgtgtttac tcaggtgttc ttcaatcagg ttcatacgta   1020
ttgaatactt ctaaaggtaa acgtgaacgt atcggacgta tccttcaaat gcacgctaac   1080
agccgtcaag aaatcgacac tgtttactca ggtgatatcg ctgctgccgt tggtttgaaa   1140
gatactacaa ctggtgactc attgacagat gaaaaagcta aaatcatcct tgagtcaatc   1200
aacgttccag aaccagttat ccaattgatg gttgagccaa aatctaaagc tgaccaagac   1260
aagatgggta tcgcccttca aaaattggct gaagaagatc caacattccg cgttgaaaca   1320
aacgttgaaa ctggtgaaac agttatctca ggtatgggtg aacttcacct tgacgtcctt   1380
gttgatcgta tgcgtcgtga gttcaaagtt gaagcgaacg taggtgctcc tcaagtatct   1440
taccgtgaaa cattccgcgc ttctactcaa gcacgtggat tcttcaaacg tcagtctggt   1500
ggtaaaggtc aattcggtga tgtatggatt gaatttactc caaacgaaga aggtaaagga   1560
ttcgaattcg aaaacgcaat cgtcggtggt gtggttcctc gtgaatttat cccagcggtt   1620
gaaaaaggtt tggtagaatc tatggctaac ggtgttcttg caggttaccc aatggttgac   1680
gttaaagcta agctttatga tggttcatat cacgatgtcg actcatctga aactgccttc   1740
aagattgcgg cttcactttc ccttaaagaa gctgctaaat cagcacaacc agctatcctt   1800
gaaccaatga tgcttgtaac aatcactgtt ccagaagaaa accttggtga tgttatgggt   1860
cacgtaactg ctcgtcgtgg acgtgtagat ggtatggaag cacacggtaa cagccaaatc   1920
gttcgtgctt acgttccact tgctgaaatg ttcggttacg caacagttct tcgttctgca   1980
tctcaaggac gtggtacatt catgatggta tttgaccact acgaagatgt acctaagtca   2040
gtacaagaag aaattattaa gaaaaataaa ggtgaagac                          2079

<210>   374
<211>   693
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   translation elongation factor G (fusA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902294 (0.E+01)

<400>   374
Met Ala Arg Glu Phe Ser Leu Glu Lys Thr Arg Asn Ile Gly Ile Met 
1               5                   10                  15      

Ala His Val Asp Ala Gly Lys Thr Thr Thr Thr Glu Arg Ile Leu Tyr 
            20                  25                  30          

Tyr Thr Gly Lys Ile His Lys Ile Gly Glu Thr His Glu Gly Ala Ser 
        35                  40                  45              


Gln Met Asp Trp Met Glu Gln Glu Gln Glu Arg Gly Ile Thr Ile Thr 
    50                  55                  60                  

Ser Ala Ala Thr Thr Ala Gln Trp Asn Asn His Arg Val Asn Ile Ile 
65                  70                  75                  80  

Asp Thr Pro Gly His Val Asp Phe Thr Ile Glu Val Gln Arg Ser Leu 
                85                  90                  95      

Arg Val Leu Asp Gly Ala Val Thr Val Leu Asp Ser Gln Ser Gly Val 
            100                 105                 110         

Glu Pro Gln Thr Glu Thr Val Trp Arg Gln Ala Thr Glu Tyr Gly Val 
        115                 120                 125             

Pro Arg Ile Val Phe Ala Asn Lys Met Asp Lys Ile Gly Ala Asp Phe 
    130                 135                 140                 

Leu Tyr Ser Val Ser Thr Leu His Asp Arg Leu Gln Ala Asn Ala His 
145                 150                 155                 160 

Pro Ile Gln Leu Pro Ile Gly Ser Glu Asp Asp Phe Arg Gly Ile Ile 
                165                 170                 175     

Asp Leu Ile Lys Met Lys Ala Glu Ile Tyr Thr Asn Asp Leu Gly Thr 
            180                 185                 190         

Asp Ile Leu Glu Glu Asp Ile Pro Ala Glu Tyr Leu Asp Gln Ala Gln 
        195                 200                 205             

Glu Tyr Arg Glu Lys Leu Ile Glu Ala Val Ala Glu Thr Asp Glu Glu 
    210                 215                 220                 

Leu Met Met Lys Tyr Leu Glu Gly Glu Glu Ile Thr Asn Glu Glu Leu 
225                 230                 235                 240 

Lys Ala Gly Ile Arg Lys Ala Thr Ile Asn Val Glu Phe Phe Pro Val 
                245                 250                 255     

Leu Cys Gly Ser Ala Phe Lys Asn Lys Gly Val Gln Leu Met Leu Asp 
            260                 265                 270         

Ala Val Ile Asp Tyr Leu Pro Ser Pro Leu Asp Ile Pro Ala Ile Lys 
        275                 280                 285             

Gly Ile Asn Pro Asp Thr Asp Ala Glu Glu Ile Arg Pro Ala Ser Asp 
    290                 295                 300                 

Glu Glu Pro Phe Ala Ala Leu Ala Phe Lys Ile Met Thr Asp Pro Phe 
305                 310                 315                 320 

Val Gly Arg Leu Thr Phe Phe Arg Val Tyr Ser Gly Val Leu Gln Ser 
                325                 330                 335     

Gly Ser Tyr Val Leu Asn Thr Ser Lys Gly Lys Arg Glu Arg Ile Gly 
            340                 345                 350         

Arg Ile Leu Gln Met His Ala Asn Ser Arg Gln Glu Ile Asp Thr Val 
        355                 360                 365             

Tyr Ser Gly Asp Ile Ala Ala Ala Val Gly Leu Lys Asp Thr Thr Thr 
    370                 375                 380                 


Gly Asp Ser Leu Thr Asp Glu Lys Ala Lys Ile Ile Leu Glu Ser Ile 
385                 390                 395                 400 

Asn Val Pro Glu Pro Val Ile Gln Leu Met Val Glu Pro Lys Ser Lys 
                405                 410                 415     

Ala Asp Gln Asp Lys Met Gly Ile Ala Leu Gln Lys Leu Ala Glu Glu 
            420                 425                 430         

Asp Pro Thr Phe Arg Val Glu Thr Asn Val Glu Thr Gly Glu Thr Val 
        435                 440                 445             

Ile Ser Gly Met Gly Glu Leu His Leu Asp Val Leu Val Asp Arg Met 
    450                 455                 460                 

Arg Arg Glu Phe Lys Val Glu Ala Asn Val Gly Ala Pro Gln Val Ser 
465                 470                 475                 480 

Tyr Arg Glu Thr Phe Arg Ala Ser Thr Gln Ala Arg Gly Phe Phe Lys 
                485                 490                 495     

Arg Gln Ser Gly Gly Lys Gly Gln Phe Gly Asp Val Trp Ile Glu Phe 
            500                 505                 510         

Thr Pro Asn Glu Glu Gly Lys Gly Phe Glu Phe Glu Asn Ala Ile Val 
        515                 520                 525             

Gly Gly Val Val Pro Arg Glu Phe Ile Pro Ala Val Glu Lys Gly Leu 
    530                 535                 540                 

Val Glu Ser Met Ala Asn Gly Val Leu Ala Gly Tyr Pro Met Val Asp 
545                 550                 555                 560 

Val Lys Ala Lys Leu Tyr Asp Gly Ser Tyr His Asp Val Asp Ser Ser 
                565                 570                 575     

Glu Thr Ala Phe Lys Ile Ala Ala Ser Leu Ser Leu Lys Glu Ala Ala 
            580                 585                 590         

Lys Ser Ala Gln Pro Ala Ile Leu Glu Pro Met Met Leu Val Thr Ile 
        595                 600                 605             

Thr Val Pro Glu Glu Asn Leu Gly Asp Val Met Gly His Val Thr Ala 
    610                 615                 620                 

Arg Arg Gly Arg Val Asp Gly Met Glu Ala His Gly Asn Ser Gln Ile 
625                 630                 635                 640 

Val Arg Ala Tyr Val Pro Leu Ala Glu Met Phe Gly Tyr Ala Thr Val 
                645                 650                 655     

Leu Arg Ser Ala Ser Gln Gly Arg Gly Thr Phe Met Met Val Phe Asp 
            660                 665                 670         

His Tyr Glu Asp Val Pro Lys Ser Val Gln Glu Glu Ile Ile Lys Lys 
        675                 680                 685             

Asn Lys Gly Glu Asp 
    690             

<210>   375
<211>   4389
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   375
atgtcaaata gttttgaaat tttgatgaat caattgggga tgcctgctga aatgagacag   60
gctcctgctt tagcacaggc caatattgag cgagttgtgg ttcataaaat tagtaaggta   120
tgggagtttc atttcgtatt ttctaatatt ttaccgattg aaatcttttt agaattaaag   180
aaaggtttga gcgaagaatt ttctaagaca ggcaataaag ctgtttttga aattaaggct   240
cggtctcaag aattttcaaa tcagctcttg cagtcctact atagggaggc tttctctgaa   300
ggtccatgtg ctagtcaagg ttttaagtcc ctttatcaaa atttgcaagt tcgtgctgag   360
ggtaatcagc tatttattga aggatctgaa gcgattgata aggaacattt taagaagaat   420
catcttccta atttagccaa acaacttgaa aagtttggtt ttccaacttt taactgtcaa   480
gtcgagaaga atgatgtcct gacccaagag caggaagagg cctttcatgc tgaaaatgag   540
cagattgttc aagctgccaa tgaggaagcg ctccgtgcta tggaacaact ggagcagatg   600
gcacctcctc cagcggaaga gaaaccagcc tttgattttc aagcgaaaaa agctgcagct   660
aaacccaagc tggataaggc ggagattact cctatgatcg aagtgacgac agaggaaaat   720
cgtctggtat ttgaaggggt tgtttttgat gtggagcaaa aagtgactag aacaggtcgt   780
gttttaatca actttaaaat gacggactat acttcaagtt tttctatgca aaagtgggtt   840
aaaaacgagg aagaggccca gaagtttgac ctcatcaaga agaattcttg gctccgagtt   900
cgagggaatg tggagatgaa taacttcaca cgcgatttga ctatgaacgt acaggatctg   960
caggaagttg ttcactatga gcggaaggat ttgatgccag aaggtgagcg tcgggttgag   1020
tttcatgctc atactaacat gtcgactatg gatgctttgc cagaggtcga agagattgtt   1080
gcaacagctg ctaagtgggg acacaaggcg gttgctatca cggaccatgg gaatgtccag   1140
tcctttccac atggctataa ggcggctaag aaagcgggaa tccagctgat ctatgggatg   1200
gaagccaata tcgtggagga ccgtgtccct atcgtctata acgaagtgga gatggacttg   1260
tcagaagcaa cctacgtggt ctttgacgtg gaaacgacgg gactttcagc tatctataat   1320
gacttgattc aggttgcggc ttctaagatg tacaagggga atgttattgc tgaatttgat   1380
gaatttatca atcctgggca tcccttgtca gcctttacta cagagttaac tggaattaca   1440
gatgatcatg tcaaaaatgc caaaccacta gaacaagttt tgcaagaatt ccaagaattt   1500
tgcaaggata cggtcctagt tgcccacaat gctacctttg acgttggctt tatgaatgct   1560
aattatgagc ggcatgatct tccaaagatt agtcagccag ttattgatac gctggagttt   1620
gctagaaacc tctatcctga gtataaacgc catggtttgg ggcctttgac caagcgtttt   1680
ggtgtggcct tggaacatca ccacatggcc aactacgatg cggaagcgac tggtcgtctg   1740
cttttcatct ttatcaaaga ggtagcagaa aaacatggtg tgaccgattt agctagactc   1800
aacattgatc taatcagtcc agattcttac aaaaaagctc ggatcaagca tgcgaccatc   1860
tatgtcaaga atcaggtagg tctaaaaaat atctttaagc tggtttcctt gtctaatacc   1920
aagtattttg aaggagtgcc acggattccg agaacggttc tagatgccca tcgagagggc   1980
ttgattttag gttcagcctg ttcagagggt gaagtttttg acgtggtcgt ttctcaaggt   2040
gtggatgcgg cggttgaggt ggccaagtat tatgatttta tcgaggtcat gccaccggct   2100
atctatgcac ccttgattgc caaagagcag gtcaaggata tggaggaact ccagaccatt   2160
atcaagagtt tgatagaggt tggagaccgc cttggcaagc ctgttctggc tacgggaaat   2220
gttcactata tcgaaccgga agaagagatt tatcgtgaaa ttatcgtccg tagtttggga   2280
cagggtgcga tgattaatcg aactatcggt catggtgaac atgcccaacc agcaccactt   2340
ccaaaggctc attttcgaac gactaatgag atgttggatg aatttgcctt tttgggagag   2400
gaactggctc gtaaactggt tattgaaaac accaatgcct tggcagaaat atttgaatcc   2460
gttgaagtcg ttaagggtga cttgtatacg cctttcatcg acaaggctga agaaacagtt   2520
gctgagttga cctataagaa agcttttgag atttatggaa atccgctgcc agatattgtt   2580
gatttgcgga ttgaaaaaga attaacatcc atactgggga atggatttgc tgtgatttat   2640
ctggcatcgc agatgctggt gcaacgttct aatgaacggg gttatttggt tggttctcgt   2700
gggtctgtcg gatctagttt cgttgcgacc atgattggga ttacggaggt caatcctctc   2760
tctcctcact atgtctgtgg tcagtgtcag tacagtgagt ttatcacaga tggttcgtac   2820
ggttcaggat ttgatatgcc ccataaggac tgtccaaact gtggtcacaa actcagtaaa   2880
aacggacagg atattccgtt tgagaccttc cttggttttg atggggataa ggttcctgat   2940
attgacttga acttctcggg agaagatcag cctagcgccc acttggatgt gcgtgatatc   3000
tttggtgaag aatatgcctt ccgtgcggga acggttggta cggtagctgc caagactgcc   3060
tatggatttg tcaaaggtta cgagcgagat tatggcaagt tttatcgtga tgcagaagta   3120
gaacgcctcg ctcaaggagc ggcgggtgtc aagcggacaa caggccaaca cccgggggga   3180
atcgttgtta ttccgaacta catggatgtc tacgatttta cgcctgtcca gtatccagca   3240
gatgatgtca cggctgaatg gcagaccact cactttaact tccacgatat cgatgagaac   3300
gtcctcaaac tcgatgtact gggacatgat gatccgacta tgattcgaaa acttcaggat   3360
ttgtctggta ttgaccctaa taaaattcct atggatgacg aaggcgtgat ggcactcttt   3420
tctgggactg atgtgctagg ggtaacacct gaacaaattg gaacgcctac gggtatgttg   3480
gggattccag agtttggaac aaatttcgta cgtggaatgg tagacgaaac ccatccgaca   3540
acctttgcgg aattgcttca gctgtctggt ctgtcccacg gtactgatgt ttggttgggg   3600
aatgctcagg atctgattaa gcaaggaata gcggacctat cgactgttat cggttgtcgg   3660
gacgacatca tggtttacct catgcatgcg ggtctggaac ctaagatggc ctttaccatt   3720
atggaacggg tacgtaaggg tttgtggcta aagatttcag aagaggagag aaatggctat   3780
atcgaagcaa tgaaggctaa taaggtgcca gagtggtata tcgaatcctg tgggaaaatt   3840
aagtacatgt tccctaaggc ccatgcggca gcctacgtta tgatggcctt gcgtgtagct   3900
tacttcaagg ttcaccatcc tatttattac tactgtgctt acttctccat tcgtgctaag   3960
gcttttgata tcaagaccat gggtgcgggc ttggaggtca tcaagcgcag aatggaagaa   4020
atctctgaaa aacggaagaa caatgaagcc tctaatgtgg aaatcgatct ctatacaact   4080
cttgagattg tcaatgagat gtgggaacga ggtttcaagt ttggtaaatt agatctctac   4140
tgtagtcagg cgacagagtt cctcatcgac ggggataccc ttatcccacc atttgtagca   4200
atggatggtc tgggagagaa cgttgccaag caactggtgc gggcgcgtga agagggagaa   4260
ttcctctcta aaacagaact acgcaagcgt ggtggactct catcaacctt ggttgaaaag   4320
atggatgaga tgggtattct tggaaatatg ccagaggata accagttgag tttgtttgat   4380
gagttgttt                                                           4389

<210>   376
<211>   1463
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA polymerase III, alpha subunit, Gram-positive type
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902295 (0.E+01)

<400>   376
Met Ser Asn Ser Phe Glu Ile Leu Met Asn Gln Leu Gly Met Pro Ala 
1               5                   10                  15      

Glu Met Arg Gln Ala Pro Ala Leu Ala Gln Ala Asn Ile Glu Arg Val 
            20                  25                  30          

Val Val His Lys Ile Ser Lys Val Trp Glu Phe His Phe Val Phe Ser 
        35                  40                  45              

Asn Ile Leu Pro Ile Glu Ile Phe Leu Glu Leu Lys Lys Gly Leu Ser 
    50                  55                  60                  

Glu Glu Phe Ser Lys Thr Gly Asn Lys Ala Val Phe Glu Ile Lys Ala 
65                  70                  75                  80  

Arg Ser Gln Glu Phe Ser Asn Gln Leu Leu Gln Ser Tyr Tyr Arg Glu 
                85                  90                  95      

Ala Phe Ser Glu Gly Pro Cys Ala Ser Gln Gly Phe Lys Ser Leu Tyr 
            100                 105                 110         

Gln Asn Leu Gln Val Arg Ala Glu Gly Asn Gln Leu Phe Ile Glu Gly 
        115                 120                 125             

Ser Glu Ala Ile Asp Lys Glu His Phe Lys Lys Asn His Leu Pro Asn 
    130                 135                 140                 

Leu Ala Lys Gln Leu Glu Lys Phe Gly Phe Pro Thr Phe Asn Cys Gln 
145                 150                 155                 160 

Val Glu Lys Asn Asp Val Leu Thr Gln Glu Gln Glu Glu Ala Phe His 
                165                 170                 175     

Ala Glu Asn Glu Gln Ile Val Gln Ala Ala Asn Glu Glu Ala Leu Arg 
            180                 185                 190         

Ala Met Glu Gln Leu Glu Gln Met Ala Pro Pro Pro Ala Glu Glu Lys 
        195                 200                 205             

Pro Ala Phe Asp Phe Gln Ala Lys Lys Ala Ala Ala Lys Pro Lys Leu 
    210                 215                 220                 

Asp Lys Ala Glu Ile Thr Pro Met Ile Glu Val Thr Thr Glu Glu Asn 
225                 230                 235                 240 

Arg Leu Val Phe Glu Gly Val Val Phe Asp Val Glu Gln Lys Val Thr 
                245                 250                 255     

Arg Thr Gly Arg Val Leu Ile Asn Phe Lys Met Thr Asp Tyr Thr Ser 
            260                 265                 270         

Ser Phe Ser Met Gln Lys Trp Val Lys Asn Glu Glu Glu Ala Gln Lys 
        275                 280                 285             

Phe Asp Leu Ile Lys Lys Asn Ser Trp Leu Arg Val Arg Gly Asn Val 
    290                 295                 300                 

Glu Met Asn Asn Phe Thr Arg Asp Leu Thr Met Asn Val Gln Asp Leu 
305                 310                 315                 320 

Gln Glu Val Val His Tyr Glu Arg Lys Asp Leu Met Pro Glu Gly Glu 
                325                 330                 335     

Arg Arg Val Glu Phe His Ala His Thr Asn Met Ser Thr Met Asp Ala 
            340                 345                 350         

Leu Pro Glu Val Glu Glu Ile Val Ala Thr Ala Ala Lys Trp Gly His 
        355                 360                 365             

Lys Ala Val Ala Ile Thr Asp His Gly Asn Val Gln Ser Phe Pro His 
    370                 375                 380                 

Gly Tyr Lys Ala Ala Lys Lys Ala Gly Ile Gln Leu Ile Tyr Gly Met 
385                 390                 395                 400 

Glu Ala Asn Ile Val Glu Asp Arg Val Pro Ile Val Tyr Asn Glu Val 
                405                 410                 415     

Glu Met Asp Leu Ser Glu Ala Thr Tyr Val Val Phe Asp Val Glu Thr 
            420                 425                 430         

Thr Gly Leu Ser Ala Ile Tyr Asn Asp Leu Ile Gln Val Ala Ala Ser 
        435                 440                 445             

Lys Met Tyr Lys Gly Asn Val Ile Ala Glu Phe Asp Glu Phe Ile Asn 
    450                 455                 460                 

Pro Gly His Pro Leu Ser Ala Phe Thr Thr Glu Leu Thr Gly Ile Thr 
465                 470                 475                 480 

Asp Asp His Val Lys Asn Ala Lys Pro Leu Glu Gln Val Leu Gln Glu 
                485                 490                 495     

Phe Gln Glu Phe Cys Lys Asp Thr Val Leu Val Ala His Asn Ala Thr 
            500                 505                 510         

Phe Asp Val Gly Phe Met Asn Ala Asn Tyr Glu Arg His Asp Leu Pro 
        515                 520                 525             

Lys Ile Ser Gln Pro Val Ile Asp Thr Leu Glu Phe Ala Arg Asn Leu 
    530                 535                 540                 

Tyr Pro Glu Tyr Lys Arg His Gly Leu Gly Pro Leu Thr Lys Arg Phe 
545                 550                 555                 560 

Gly Val Ala Leu Glu His His His Met Ala Asn Tyr Asp Ala Glu Ala 
                565                 570                 575     

Thr Gly Arg Leu Leu Phe Ile Phe Ile Lys Glu Val Ala Glu Lys His 
            580                 585                 590         

Gly Val Thr Asp Leu Ala Arg Leu Asn Ile Asp Leu Ile Ser Pro Asp 
        595                 600                 605             

Ser Tyr Lys Lys Ala Arg Ile Lys His Ala Thr Ile Tyr Val Lys Asn 
    610                 615                 620                 

Gln Val Gly Leu Lys Asn Ile Phe Lys Leu Val Ser Leu Ser Asn Thr 
625                 630                 635                 640 

Lys Tyr Phe Glu Gly Val Pro Arg Ile Pro Arg Thr Val Leu Asp Ala 
                645                 650                 655     

His Arg Glu Gly Leu Ile Leu Gly Ser Ala Cys Ser Glu Gly Glu Val 
            660                 665                 670         

Phe Asp Val Val Val Ser Gln Gly Val Asp Ala Ala Val Glu Val Ala 
        675                 680                 685             

Lys Tyr Tyr Asp Phe Ile Glu Val Met Pro Pro Ala Ile Tyr Ala Pro 
    690                 695                 700                 

Leu Ile Ala Lys Glu Gln Val Lys Asp Met Glu Glu Leu Gln Thr Ile 
705                 710                 715                 720 

Ile Lys Ser Leu Ile Glu Val Gly Asp Arg Leu Gly Lys Pro Val Leu 
                725                 730                 735     

Ala Thr Gly Asn Val His Tyr Ile Glu Pro Glu Glu Glu Ile Tyr Arg 
            740                 745                 750         

Glu Ile Ile Val Arg Ser Leu Gly Gln Gly Ala Met Ile Asn Arg Thr 
        755                 760                 765             

Ile Gly His Gly Glu His Ala Gln Pro Ala Pro Leu Pro Lys Ala His 
    770                 775                 780                 

Phe Arg Thr Thr Asn Glu Met Leu Asp Glu Phe Ala Phe Leu Gly Glu 
785                 790                 795                 800 

Glu Leu Ala Arg Lys Leu Val Ile Glu Asn Thr Asn Ala Leu Ala Glu 
                805                 810                 815     

Ile Phe Glu Ser Val Glu Val Val Lys Gly Asp Leu Tyr Thr Pro Phe 
            820                 825                 830         

Ile Asp Lys Ala Glu Glu Thr Val Ala Glu Leu Thr Tyr Lys Lys Ala 
        835                 840                 845             

Phe Glu Ile Tyr Gly Asn Pro Leu Pro Asp Ile Val Asp Leu Arg Ile 
    850                 855                 860                 

Glu Lys Glu Leu Thr Ser Ile Leu Gly Asn Gly Phe Ala Val Ile Tyr 
865                 870                 875                 880 

Leu Ala Ser Gln Met Leu Val Gln Arg Ser Asn Glu Arg Gly Tyr Leu 
                885                 890                 895     

Val Gly Ser Arg Gly Ser Val Gly Ser Ser Phe Val Ala Thr Met Ile 
            900                 905                 910         

Gly Ile Thr Glu Val Asn Pro Leu Ser Pro His Tyr Val Cys Gly Gln 
        915                 920                 925             

Cys Gln Tyr Ser Glu Phe Ile Thr Asp Gly Ser Tyr Gly Ser Gly Phe 
    930                 935                 940                 

Asp Met Pro His Lys Asp Cys Pro Asn Cys Gly His Lys Leu Ser Lys 
945                 950                 955                 960 

Asn Gly Gln Asp Ile Pro Phe Glu Thr Phe Leu Gly Phe Asp Gly Asp 
                965                 970                 975     

Lys Val Pro Asp Ile Asp Leu Asn Phe Ser Gly Glu Asp Gln Pro Ser 
            980                 985                 990         

Ala His Leu Asp Val Arg Asp Ile Phe Gly Glu Glu Tyr Ala Phe Arg 
        995                 1000                1005            

Ala Gly Thr Val Gly Thr Val Ala Ala Lys Thr Ala Tyr Gly Phe Val 
    1010                1015                1020                

Lys Gly Tyr Glu Arg Asp Tyr Gly Lys Phe Tyr Arg Asp Ala Glu Val 
1025                1030                1035                1040

Glu Arg Leu Ala Gln Gly Ala Ala Gly Val Lys Arg Thr Thr Gly Gln 
                1045                1050                1055    

His Pro Gly Gly Ile Val Val Ile Pro Asn Tyr Met Asp Val Tyr Asp 
            1060                1065                1070        

Phe Thr Pro Val Gln Tyr Pro Ala Asp Asp Val Thr Ala Glu Trp Gln 
        1075                1080                1085            

Thr Thr His Phe Asn Phe His Asp Ile Asp Glu Asn Val Leu Lys Leu 
    1090                1095                1100                

Asp Val Leu Gly His Asp Asp Pro Thr Met Ile Arg Lys Leu Gln Asp 
1105                1110                1115                1120

Leu Ser Gly Ile Asp Pro Asn Lys Ile Pro Met Asp Asp Glu Gly Val 
                1125                1130                1135    

Met Ala Leu Phe Ser Gly Thr Asp Val Leu Gly Val Thr Pro Glu Gln 
            1140                1145                1150        

Ile Gly Thr Pro Thr Gly Met Leu Gly Ile Pro Glu Phe Gly Thr Asn 
        1155                1160                1165            

Phe Val Arg Gly Met Val Asp Glu Thr His Pro Thr Thr Phe Ala Glu 
    1170                1175                1180                

Leu Leu Gln Leu Ser Gly Leu Ser His Gly Thr Asp Val Trp Leu Gly 
1185                1190                1195                1200

Asn Ala Gln Asp Leu Ile Lys Gln Gly Ile Ala Asp Leu Ser Thr Val 
                1205                1210                1215    

Ile Gly Cys Arg Asp Asp Ile Met Val Tyr Leu Met His Ala Gly Leu 
            1220                1225                1230        

Glu Pro Lys Met Ala Phe Thr Ile Met Glu Arg Val Arg Lys Gly Leu 
        1235                1240                1245            

Trp Leu Lys Ile Ser Glu Glu Glu Arg Asn Gly Tyr Ile Glu Ala Met 
    1250                1255                1260                

Lys Ala Asn Lys Val Pro Glu Trp Tyr Ile Glu Ser Cys Gly Lys Ile 
1265                1270                1275                1280

Lys Tyr Met Phe Pro Lys Ala His Ala Ala Ala Tyr Val Met Met Ala 
                1285                1290                1295    

Leu Arg Val Ala Tyr Phe Lys Val His His Pro Ile Tyr Tyr Tyr Cys 
            1300                1305                1310        

Ala Tyr Phe Ser Ile Arg Ala Lys Ala Phe Asp Ile Lys Thr Met Gly 
        1315                1320                1325            

Ala Gly Leu Glu Val Ile Lys Arg Arg Met Glu Glu Ile Ser Glu Lys 
    1330                1335                1340                

Arg Lys Asn Asn Glu Ala Ser Asn Val Glu Ile Asp Leu Tyr Thr Thr 
1345                1350                1355                1360

Leu Glu Ile Val Asn Glu Met Trp Glu Arg Gly Phe Lys Phe Gly Lys 
                1365                1370                1375    

Leu Asp Leu Tyr Cys Ser Gln Ala Thr Glu Phe Leu Ile Asp Gly Asp 
            1380                1385                1390        

Thr Leu Ile Pro Pro Phe Val Ala Met Asp Gly Leu Gly Glu Asn Val 
        1395                1400                1405            

Ala Lys Gln Leu Val Arg Ala Arg Glu Glu Gly Glu Phe Leu Ser Lys 
    1410                1415                1420                

Thr Glu Leu Arg Lys Arg Gly Gly Leu Ser Ser Thr Leu Val Glu Lys 
1425                1430                1435                1440

Met Asp Glu Met Gly Ile Leu Gly Asn Met Pro Glu Asp Asn Gln Leu 
                1445                1450                1455    

Ser Leu Phe Asp Glu Leu Phe 
            1460            

<210>   377
<211>   261
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   377
atgtcaaaga tgagtataag catccgtctg gatagtgagg ttaaggagca ggcccaacag   60
gtgtttagta atctgggaat ggatatgaca acagctatta atattttcct tcgtcaggca   120
attcaatatc agggattacc ttttgatgtt agactagacg aaaatcggaa gttgctccaa   180
gcgttaacgg atttagacca aaatcgtaat atgagccagt cttttgaatc agtctcagat   240
ttgatggagg acttacgtgc t                                             261

<210>   378
<211>   87
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902296 (4.E-43)

<400>   378
Met Ser Lys Met Ser Ile Ser Ile Arg Leu Asp Ser Glu Val Lys Glu 
1               5                   10                  15      

Gln Ala Gln Gln Val Phe Ser Asn Leu Gly Met Asp Met Thr Thr Ala 
            20                  25                  30          

Ile Asn Ile Phe Leu Arg Gln Ala Ile Gln Tyr Gln Gly Leu Pro Phe 
        35                  40                  45              

Asp Val Arg Leu Asp Glu Asn Arg Lys Leu Leu Gln Ala Leu Thr Asp 
    50                  55                  60                  

Leu Asp Gln Asn Arg Asn Met Ser Gln Ser Phe Glu Ser Val Ser Asp 
65                  70                  75                  80  

Leu Met Glu Asp Leu Arg Ala 
                85          

<210>   379
<211>   276
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   379
gtgcttaaga ttcgttatca taaacagttt aaaaaagatt ttaagttggc tatgaagcgt   60
ggtttgaagg cagaattatt agaagaagtt ttgaattttc tggttcaaga aaaagaacat   120
cctgccagaa atcgtgatca ttcattgacg gcatccaagc attttcaagg agttcgtgaa   180
tgccataccc agccagattg gcttttggtt tataaagtag acaagtcgga attgatttta   240
aatttgctga ggacaggcag tcacagtgat ttattt                             276

<210>   380
<211>   92
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902297 (2.E-49)

<400>   380
Met Leu Lys Ile Arg Tyr His Lys Gln Phe Lys Lys Asp Phe Lys Leu 
1               5                   10                  15      

Ala Met Lys Arg Gly Leu Lys Ala Glu Leu Leu Glu Glu Val Leu Asn 
            20                  25                  30          

Phe Leu Val Gln Glu Lys Glu His Pro Ala Arg Asn Arg Asp His Ser 
        35                  40                  45              

Leu Thr Ala Ser Lys His Phe Gln Gly Val Arg Glu Cys His Thr Gln 
    50                  55                  60                  

Pro Asp Trp Leu Leu Val Tyr Lys Val Asp Lys Ser Glu Leu Ile Leu 
65                  70                  75                  80  

Asn Leu Leu Arg Thr Gly Ser His Ser Asp Leu Phe 
                85                  90          

<210>   381
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   381
atgaaactaa gaatatttgc ggaagataag ccggctaaga aggtatttga atatcaatta   60
gaacttgctg atcgtacaat tcttctatcg acagcactct tgtcaggtgc tattgcttta   120
gcaggaatct tttctgcttt gaaagaaaaa                                    150

<210>   382
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   382
Met Lys Leu Arg Ile Phe Ala Glu Asp Lys Pro Ala Lys Lys Val Phe 
1               5                   10                  15      

Glu Tyr Gln Leu Glu Leu Ala Asp Arg Thr Ile Leu Leu Ser Thr Ala 
            20                  25                  30          

Leu Leu Ser Gly Ala Ile Ala Leu Ala Gly Ile Phe Ser Ala Leu Lys 
        35                  40                  45              

Glu Lys 
    50  

<210>   383
<211>   1239
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   383
atggttttac caaattttaa agaaaatcta gaaaaatatg cgaaattgtt ggttgcgaac   60
ggaattaacg tgcaacctgg tcacactttg gctctctcta ttgatgtgga gcaacgtgaa   120
ttggcacatc taatcgtgaa agaagcttat gccttgggtg cgcatgaggt catcgttcag   180
tggacagatg atgtgattaa ccgtgagaaa ttcctccatg ccccgatgga gcgtttggac   240
aatgtgccag aatacaagat tgctgagatg aactatctct tggagaataa ggctagccgt   300
cttggagttc gttcatctga tccaggtgcc ttgaacggag tggacgctga caagctttca   360
gcttctgcta aagctatggg acttgccatg aagcctatgc gtatcgcaac tcaatctaac   420
aaggttagct ggactgtagc agctgcagca ggacttgagt gggctaagaa agtcttccca   480
aatgctgcga gcgacgaaga agcagttgat ttcctttggg accaaatttt caaaacttgc   540
cgtgtctacg aagcagatcc tgttaaggct tgggaggaac atgcagccat tctcaagagc   600
aaggccgata tgcttaataa ggagcaattt tcagcccttc actacacagc gccaggaaca   660
gatttaacac ttggtttgcc aaagaaccac gtttgggaat cagctggtgc tgtcaatgca   720
cagggcgaag aattcttgcc aaatatgcca acagaagagg tcttcacagc gcctgacttc   780
cgtcgtgcag atggttatgt cacttctaca aaaccgctta gctacaacgg aaatatcatt   840
gaaggcatta aggtgacctt taaggatgga caaatcgtag atatcactgc tgagaagggt   900
gatcaggtta tgaaagacct tgtctttgaa aatgcgggtg cgcgtgcctt gggtgaatgt   960
gccttggtac cagatccaag tccaatttct cagtcaggca ttaccttctt taacaccctt   1020
ttcgatgaaa atgcgtcaaa ccacttggct atcggtgcag cctatgcgac tagcgttgtt   1080
gatggagcgg agatgagcga agaggagctt gaagctgcag ggcttaaccg ttcagatgtt   1140
cacgtagact ttatgattgg ttctaaccaa atggatatcg atggtattcg tgaggatgga   1200
acgcgggtac ctcttttccg taatgggaat tgggcaaat                          1239

<210>   384
<211>   413
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aminopeptidase PepS (pepS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902298 (0.E+01)

<400>   384
Met Val Leu Pro Asn Phe Lys Glu Asn Leu Glu Lys Tyr Ala Lys Leu 
1               5                   10                  15      

Leu Val Ala Asn Gly Ile Asn Val Gln Pro Gly His Thr Leu Ala Leu 
            20                  25                  30          

Ser Ile Asp Val Glu Gln Arg Glu Leu Ala His Leu Ile Val Lys Glu 
        35                  40                  45              

Ala Tyr Ala Leu Gly Ala His Glu Val Ile Val Gln Trp Thr Asp Asp 
    50                  55                  60                  

Val Ile Asn Arg Glu Lys Phe Leu His Ala Pro Met Glu Arg Leu Asp 
65                  70                  75                  80  

Asn Val Pro Glu Tyr Lys Ile Ala Glu Met Asn Tyr Leu Leu Glu Asn 
                85                  90                  95      

Lys Ala Ser Arg Leu Gly Val Arg Ser Ser Asp Pro Gly Ala Leu Asn 
            100                 105                 110         

Gly Val Asp Ala Asp Lys Leu Ser Ala Ser Ala Lys Ala Met Gly Leu 
        115                 120                 125             

Ala Met Lys Pro Met Arg Ile Ala Thr Gln Ser Asn Lys Val Ser Trp 
    130                 135                 140                 

Thr Val Ala Ala Ala Ala Gly Leu Glu Trp Ala Lys Lys Val Phe Pro 
145                 150                 155                 160 

Asn Ala Ala Ser Asp Glu Glu Ala Val Asp Phe Leu Trp Asp Gln Ile 
                165                 170                 175     

Phe Lys Thr Cys Arg Val Tyr Glu Ala Asp Pro Val Lys Ala Trp Glu 
            180                 185                 190         

Glu His Ala Ala Ile Leu Lys Ser Lys Ala Asp Met Leu Asn Lys Glu 
        195                 200                 205             

Gln Phe Ser Ala Leu His Tyr Thr Ala Pro Gly Thr Asp Leu Thr Leu 
    210                 215                 220                 

Gly Leu Pro Lys Asn His Val Trp Glu Ser Ala Gly Ala Val Asn Ala 
225                 230                 235                 240 

Gln Gly Glu Glu Phe Leu Pro Asn Met Pro Thr Glu Glu Val Phe Thr 
                245                 250                 255     

Ala Pro Asp Phe Arg Arg Ala Asp Gly Tyr Val Thr Ser Thr Lys Pro 
            260                 265                 270         

Leu Ser Tyr Asn Gly Asn Ile Ile Glu Gly Ile Lys Val Thr Phe Lys 
        275                 280                 285             

Asp Gly Gln Ile Val Asp Ile Thr Ala Glu Lys Gly Asp Gln Val Met 
    290                 295                 300                 

Lys Asp Leu Val Phe Glu Asn Ala Gly Ala Arg Ala Leu Gly Glu Cys 
305                 310                 315                 320 

Ala Leu Val Pro Asp Pro Ser Pro Ile Ser Gln Ser Gly Ile Thr Phe 
                325                 330                 335     

Phe Asn Thr Leu Phe Asp Glu Asn Ala Ser Asn His Leu Ala Ile Gly 
            340                 345                 350         

Ala Ala Tyr Ala Thr Ser Val Val Asp Gly Ala Glu Met Ser Glu Glu 
        355                 360                 365             

Glu Leu Glu Ala Ala Gly Leu Asn Arg Ser Asp Val His Val Asp Phe 
    370                 375                 380                 

Met Ile Gly Ser Asn Gln Met Asp Ile Asp Gly Ile Arg Glu Asp Gly 
385                 390                 395                 400 

Thr Arg Val Pro Leu Phe Arg Asn Gly Asn Trp Ala Asn 
                405                 410             

<210>   385
<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   385
atgttaggaa gtatgttcgt tggtctccta gtgggatttt tagcaggtgc tatgaccaat   60
cgtggagagc gaatgggatg ttttggaaaa atgtttctcg gttggatcgg agcctttcta   120
ggtcacttgc tctttggaac ttgggggcca gttttatcag gaacagctat tatcccagcg   180
attttaggag ccatgattgt tttagctatt ttttggagac gaggaagt                228

<210>   386
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902299 (4.E-41)

<400>   386
Met Leu Gly Ser Met Phe Val Gly Leu Leu Val Gly Phe Leu Ala Gly 
1               5                   10                  15      

Ala Met Thr Asn Arg Gly Glu Arg Met Gly Cys Phe Gly Lys Met Phe 
            20                  25                  30          

Leu Gly Trp Ile Gly Ala Phe Leu Gly His Leu Leu Phe Gly Thr Trp 
        35                  40                  45              

Gly Pro Val Leu Ser Gly Thr Ala Ile Ile Pro Ala Ile Leu Gly Ala 
    50                  55                  60                  

Met Ile Val Leu Ala Ile Phe Trp Arg Arg Gly Ser 
65                  70                  75      

<210>   387
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   387
atgttactga cttcgtcagt tctatctgca acctcaaaac agtgttttga gctgacttcg   60
tcagttctat ctgcaacctc aaagcagtgc tttgagcatc ctgcggctag tttcctagtt   120
tgctctttga ttttcattga gtatcagatt                                    150

<210>   388
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   388
Met Leu Leu Thr Ser Ser Val Leu Ser Ala Thr Ser Lys Gln Cys Phe 
1               5                   10                  15      

Glu Leu Thr Ser Ser Val Leu Ser Ala Thr Ser Lys Gln Cys Phe Glu 
            20                  25                  30          

His Pro Ala Ala Ser Phe Leu Val Cys Ser Leu Ile Phe Ile Glu Tyr 
        35                  40                  45              

Gln Ile 
    50  

<210>   389
<211>   720
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   389
atgagattag ataaattttt agttgcctgt gcggtgggaa gtcggactga ggtcaaaaac   60
ttgctcaagg ctgggcgcgt gactgtaaat ggtaaaaaag aaaaatcagc taaattgcag   120
attgatgaaa aaatagatga gattcgcttt gatgggcaag tgttggagta tgaagagttt   180
gtctactaca tgatgaacaa gcccaaagga gttatctcag cgactgagga tcccaagcac   240
agaaccgttc tggacttgtt ggatgacttg gcgcggagta aggaagtttt cccagtagga   300
cgcttggata ttgacacgca tggtcttttg ctcttgacca atgatggtca gctggctcat   360
gttcttcttt cgcccaagcg tcatgtggac aagacttatc tggcacaagt caagggaatc   420
atgacccaag aagatgtgga gacatttgct gagggtattc ctctcaaaga ctttacctgt   480
caacccgcta tactggagct tgtatccata gatacagaaa agaatcaaag ccaaatccgt   540
gtgaccattg cagaagggaa gtttcatcag atcaagcgta tggtgggcta ctgtggcaag   600
gaagtggtgg acttgcaacg attgactatg ggaactttag tattagatga gaacctagaa   660
cgaggggaat ggcgtcgctt gaccaaggaa gaattagaaa ttctccgcgc taatattatt   720

<210>   390
<211>   240
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal small subunit pseudouridine synthase A (rsuA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902300 (e-131)

<400>   390
Met Arg Leu Asp Lys Phe Leu Val Ala Cys Ala Val Gly Ser Arg Thr 
1               5                   10                  15      

Glu Val Lys Asn Leu Leu Lys Ala Gly Arg Val Thr Val Asn Gly Lys 
            20                  25                  30          

Lys Glu Lys Ser Ala Lys Leu Gln Ile Asp Glu Lys Ile Asp Glu Ile 
        35                  40                  45              

Arg Phe Asp Gly Gln Val Leu Glu Tyr Glu Glu Phe Val Tyr Tyr Met 
    50                  55                  60                  

Met Asn Lys Pro Lys Gly Val Ile Ser Ala Thr Glu Asp Pro Lys His 
65                  70                  75                  80  

Arg Thr Val Leu Asp Leu Leu Asp Asp Leu Ala Arg Ser Lys Glu Val 
                85                  90                  95      

Phe Pro Val Gly Arg Leu Asp Ile Asp Thr His Gly Leu Leu Leu Leu 
            100                 105                 110         

Thr Asn Asp Gly Gln Leu Ala His Val Leu Leu Ser Pro Lys Arg His 
        115                 120                 125             

Val Asp Lys Thr Tyr Leu Ala Gln Val Lys Gly Ile Met Thr Gln Glu 
    130                 135                 140                 

Asp Val Glu Thr Phe Ala Glu Gly Ile Pro Leu Lys Asp Phe Thr Cys 
145                 150                 155                 160 

Gln Pro Ala Ile Leu Glu Leu Val Ser Ile Asp Thr Glu Lys Asn Gln 
                165                 170                 175     

Ser Gln Ile Arg Val Thr Ile Ala Glu Gly Lys Phe His Gln Ile Lys 
            180                 185                 190         

Arg Met Val Gly Tyr Cys Gly Lys Glu Val Val Asp Leu Gln Arg Leu 
        195                 200                 205             

Thr Met Gly Thr Leu Val Leu Asp Glu Asn Leu Glu Arg Gly Glu Trp 
    210                 215                 220                 

Arg Arg Leu Thr Lys Glu Glu Leu Glu Ile Leu Arg Ala Asn Ile Ile 
225                 230                 235                 240 


<210>   391
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   391
ttgcttcgtc aagatgctca aatcttgcgt gacttgcttg tttctggtgc agatcaagcg   60
actgttcaag ctaagaaaga agacctcttg caagaaatct ttaactttct tgctatgtca   120
ttaggacttc caccacgcaa gtttgacttt gcttatcgcg ataaagataa caactacaaa   180
agtgaaaaag gaatcacacc acaagagttt tacaagaaat atgtcaatct tcctttagaa   240
gactacgttt ctgttatcaa tgctccaact gctgataaac cttacggaaa atcttacaca   300
gttgagatgt tggggaatgt ggttggtagc cgtgcagttc gctacatcaa cgttccaatg   360
gagcgcttga aagaattggc gattgcccaa atgcaagcag gtgagactgt ttggtttggt   420
tctgatgtcg gccagctcag caaccgtaag gctggcatcc ttgcgacaga tgtttatgac   480
tttgaatcaa gcatggacat taaacttact caagacaagg ctggacgttt ggactatagt   540
gaaagcttga tgacccacgc catggtcttg acaggtgttg acttggacga aaatggtaaa   600
tcaaccaagt ggaaggttga aaactcatgg ggagacaagg tcggtacaga tggttacttt   660
gttgcctcag acgcttggat ggacgaatac acataccaaa tcgttgttcg taaggaattg   720
ctgacagcag aagaacaagc tgcctatgga gcagaaccaa tcgtacttgc accatgggat   780
ccaatgggag ccttggctga a                                             801

<210>   392
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aminopeptidase C, FRAMESHIFT (pepC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902302 (0.E+01)

<400>   392
Met Leu Arg Gln Asp Ala Gln Ile Leu Arg Asp Leu Leu Val Ser Gly 
1               5                   10                  15      

Ala Asp Gln Ala Thr Val Gln Ala Lys Lys Glu Asp Leu Leu Gln Glu 
            20                  25                  30          

Ile Phe Asn Phe Leu Ala Met Ser Leu Gly Leu Pro Pro Arg Lys Phe 
        35                  40                  45              

Asp Phe Ala Tyr Arg Asp Lys Asp Asn Asn Tyr Lys Ser Glu Lys Gly 
    50                  55                  60                  

Ile Thr Pro Gln Glu Phe Tyr Lys Lys Tyr Val Asn Leu Pro Leu Glu 
65                  70                  75                  80  

Asp Tyr Val Ser Val Ile Asn Ala Pro Thr Ala Asp Lys Pro Tyr Gly 
                85                  90                  95      

Lys Ser Tyr Thr Val Glu Met Leu Gly Asn Val Val Gly Ser Arg Ala 
            100                 105                 110         

Val Arg Tyr Ile Asn Val Pro Met Glu Arg Leu Lys Glu Leu Ala Ile 
        115                 120                 125             

Ala Gln Met Gln Ala Gly Glu Thr Val Trp Phe Gly Ser Asp Val Gly 
    130                 135                 140                 

Gln Leu Ser Asn Arg Lys Ala Gly Ile Leu Ala Thr Asp Val Tyr Asp 
145                 150                 155                 160 

Phe Glu Ser Ser Met Asp Ile Lys Leu Thr Gln Asp Lys Ala Gly Arg 
                165                 170                 175     

Leu Asp Tyr Ser Glu Ser Leu Met Thr His Ala Met Val Leu Thr Gly 
            180                 185                 190         

Val Asp Leu Asp Glu Asn Gly Lys Ser Thr Lys Trp Lys Val Glu Asn 
        195                 200                 205             

Ser Trp Gly Asp Lys Val Gly Thr Asp Gly Tyr Phe Val Ala Ser Asp 
    210                 215                 220                 

Ala Trp Met Asp Glu Tyr Thr Tyr Gln Ile Val Val Arg Lys Glu Leu 
225                 230                 235                 240 

Leu Thr Ala Glu Glu Gln Ala Ala Tyr Gly Ala Glu Pro Ile Val Leu 
                245                 250                 255     

Ala Pro Trp Asp Pro Met Gly Ala Leu Ala Glu 
            260                 265         

<210>   393
<211>   909
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   393
atgactgaaa aacttcaatt aactaaatca gatcgtaaaa aagtttggtg gcgttcaacc   60
ttcttacaag ggtcttggaa ctttgaacgg atgcaaaact tgggctgggc ttatacactc   120
attccagcta tcaaaaaact ctatactaaa aaagaagatc aaatcgctgc tcttgagcgt   180
caccttgagt tcttcaacac tcatccatac gtagctgctc cagtcatggg ggttactctt   240
gcgcttgaag aagaacgtgc taacggtgtg gaaatcgatg acgctgctat ccaaggggtt   300
aaaatcggta tgatgggacc tcttgctggt atcggtgacc cagtattctg gtttacagta   360
cgcccaatcc ttggatctct cggtgcttca cttgccctta ctggcaatat cttggggcca   420
ctcctcttct ttgttgcatg gaacttgatt cgtatgtcat tcttgtggta tgttcaagag   480
attggataca aggctggatc agaaatcact aaagatatgt ctggtggtat ccttcaagat   540
atcactaaag gagcttctat ccttgggatg ttcattcttg ctgtccttgt tcaacgctgg   600
gtaaatatta aatttgcttt cgatgtttct aaagttcaac tagatgaaaa ggcttatatc   660
cattgggata aattgccaga agggtctaaa ggtatccaag aagcattcgc acaagtagga   720
caaggattgt ctcaaactcc tgaaaaagtt actactttcc aacaaaactt ggatatgttg   780
attcctggat tatcaggact actccttact ttactttgca tgtacttact taagaaaaaa   840
gtatctccaa tcactattat ccttgccctc ttcgcagtgg gtattgtggc acatgttctt   900
cacatcatg                                                           909

<210>   394
<211>   303
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, mannose-specific IID component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902303 (e-175)

<400>   394
Met Thr Glu Lys Leu Gln Leu Thr Lys Ser Asp Arg Lys Lys Val Trp 
1               5                   10                  15      

Trp Arg Ser Thr Phe Leu Gln Gly Ser Trp Asn Phe Glu Arg Met Gln 
            20                  25                  30          

Asn Leu Gly Trp Ala Tyr Thr Leu Ile Pro Ala Ile Lys Lys Leu Tyr 
        35                  40                  45              

Thr Lys Lys Glu Asp Gln Ile Ala Ala Leu Glu Arg His Leu Glu Phe 
    50                  55                  60                  

Phe Asn Thr His Pro Tyr Val Ala Ala Pro Val Met Gly Val Thr Leu 
65                  70                  75                  80  

Ala Leu Glu Glu Glu Arg Ala Asn Gly Val Glu Ile Asp Asp Ala Ala 
                85                  90                  95      

Ile Gln Gly Val Lys Ile Gly Met Met Gly Pro Leu Ala Gly Ile Gly 
            100                 105                 110         

Asp Pro Val Phe Trp Phe Thr Val Arg Pro Ile Leu Gly Ser Leu Gly 
        115                 120                 125             

Ala Ser Leu Ala Leu Thr Gly Asn Ile Leu Gly Pro Leu Leu Phe Phe 
    130                 135                 140                 

Val Ala Trp Asn Leu Ile Arg Met Ser Phe Leu Trp Tyr Val Gln Glu 
145                 150                 155                 160 

Ile Gly Tyr Lys Ala Gly Ser Glu Ile Thr Lys Asp Met Ser Gly Gly 
                165                 170                 175     

Ile Leu Gln Asp Ile Thr Lys Gly Ala Ser Ile Leu Gly Met Phe Ile 
            180                 185                 190         

Leu Ala Val Leu Val Gln Arg Trp Val Asn Ile Lys Phe Ala Phe Asp 
        195                 200                 205             

Val Ser Lys Val Gln Leu Asp Glu Lys Ala Tyr Ile His Trp Asp Lys 
    210                 215                 220                 

Leu Pro Glu Gly Ser Lys Gly Ile Gln Glu Ala Phe Ala Gln Val Gly 
225                 230                 235                 240 

Gln Gly Leu Ser Gln Thr Pro Glu Lys Val Thr Thr Phe Gln Gln Asn 
                245                 250                 255     

Leu Asp Met Leu Ile Pro Gly Leu Ser Gly Leu Leu Leu Thr Leu Leu 
            260                 265                 270         

Cys Met Tyr Leu Leu Lys Lys Lys Val Ser Pro Ile Thr Ile Ile Leu 
        275                 280                 285             

Ala Leu Phe Ala Val Gly Ile Val Ala His Val Leu His Ile Met 
    290                 295                 300             

<210>   395
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   395
atgtctatta tttctatggt tttagtagtc gttgtagcct tctttgcagg tcttgaaggc   60
atcctcgacc agttccaatt tcaccaacca cttgtagcct gtacccttat tgggcttgta   120
acaggtcact tggaagcagg gattatcctc ggtggatcgc ttcaaatgat tgcccttggt   180
tggtcaaata tcggtgctgc tatcgctcct gatgctgcac ttgcttctgt cgctgctgcc   240
attatcatgg ttcttggtgg tgactttacc aagactggta tcggtgttgc ccaagcggtt   300
gctatccctc ttgctgtagc tggacttttc ttgacaatga ttgttcgtac aatttcagtt   360
ggtttggttc atactgcaga tgctgccgct aaaaaaggtg acttcggcgc tgtggagcgt   420
gcgcatttca tcgcgctact tttccaagga cttcgtatcg cgcttcctgc agctcttctc   480
cttatggtac caactgaaac tgtacaaagt atccttagtg ccatgccaga ctggctcaaa   540
gatggtatgg ctatcggtgg tggtatggtc gttgccgttg gttacgccat ggttatcaac   600
atgatggcaa ctcgtgaagt atggccattc ttcgctcttg gtttcgttct cgctgctgtg   660
tcagatatta ctctaatcgg attcggtgct atcggcgttg ctatcgctct tatctacctt   720
cacctttcta aaactggtgg aaatggtggc ggaggagccg caacttctaa cgacccaatc   780
ggcgatatcc tagaagacta c                                             801

<210>   396
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, mannose-specific IIC component (manM)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902304 (e-147)

<400>   396
Met Ser Ile Ile Ser Met Val Leu Val Val Val Val Ala Phe Phe Ala 
1               5                   10                  15      

Gly Leu Glu Gly Ile Leu Asp Gln Phe Gln Phe His Gln Pro Leu Val 
            20                  25                  30          

Ala Cys Thr Leu Ile Gly Leu Val Thr Gly His Leu Glu Ala Gly Ile 
        35                  40                  45              

Ile Leu Gly Gly Ser Leu Gln Met Ile Ala Leu Gly Trp Ser Asn Ile 
    50                  55                  60                  

Gly Ala Ala Ile Ala Pro Asp Ala Ala Leu Ala Ser Val Ala Ala Ala 
65                  70                  75                  80  

Ile Ile Met Val Leu Gly Gly Asp Phe Thr Lys Thr Gly Ile Gly Val 
                85                  90                  95      

Ala Gln Ala Val Ala Ile Pro Leu Ala Val Ala Gly Leu Phe Leu Thr 
            100                 105                 110         

Met Ile Val Arg Thr Ile Ser Val Gly Leu Val His Thr Ala Asp Ala 
        115                 120                 125             

Ala Ala Lys Lys Gly Asp Phe Gly Ala Val Glu Arg Ala His Phe Ile 
    130                 135                 140                 

Ala Leu Leu Phe Gln Gly Leu Arg Ile Ala Leu Pro Ala Ala Leu Leu 
145                 150                 155                 160 

Leu Met Val Pro Thr Glu Thr Val Gln Ser Ile Leu Ser Ala Met Pro 
                165                 170                 175     

Asp Trp Leu Lys Asp Gly Met Ala Ile Gly Gly Gly Met Val Val Ala 
            180                 185                 190         

Val Gly Tyr Ala Met Val Ile Asn Met Met Ala Thr Arg Glu Val Trp 
        195                 200                 205             

Pro Phe Phe Ala Leu Gly Phe Val Leu Ala Ala Val Ser Asp Ile Thr 
    210                 215                 220                 

Leu Ile Gly Phe Gly Ala Ile Gly Val Ala Ile Ala Leu Ile Tyr Leu 
225                 230                 235                 240 

His Leu Ser Lys Thr Gly Gly Asn Gly Gly Gly Gly Ala Ala Thr Ser 
                245                 250                 255     

Asn Asp Pro Ile Gly Asp Ile Leu Glu Asp Tyr 
            260                 265         

<210>   397
<211>   996
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   397
atgacaataa tgagtatcgg aatcattatt gcgagccacg gcgaatttgc tgcgggtatt   60
catcagtcag gatctatgat ctttggtgaa caagaaaagg ttcaagttgt gacctttatg   120
ccaaatgaag gtcctgatga tctatacgct aagtttaata acgctgttgc tgcatttgac   180
gcagaagatg aggttctagt tttggctgac ctttggagtg gttctccatt taaccaagct   240
agtcgcgtga tgggagaaaa tcctgagcgt aagtttgcca tcatcacagg acttaactta   300
ccgatgttga ttcaagccta cacagagcgc ctcatggacg ctgctgcagg tgtagaaaaa   360
gtcgctgcta atatcattaa agaagccaaa gatggcatca aagctcttcc agaagagcta   420
aatccagtcg aagaagttgc aagcgctgca gctgctccag ttgcccaaac tgctatccca   480
gaaggaactg ttatcggaga cggtaaattg aaaatcaatc ttgcccgtct tgacacacgt   540
ctacttcacg gtcaggttgc aactgcttgg actccagatt caaaagcaaa tcgtatcatc   600
gttgcttcag ataacgtggc taaagacgac cttcgtaaag aattgattaa acaagcagct   660
ccaggtaatg tcaaggctaa cgtggttcca attcaaaaac tgattgagat ttcaaaagac   720
ccacgttttg gagaaacaca tgcccttatc ttgtttgaaa cacctcaaga tgcccttcgt   780
gccatcgaag gcggcgtgcc aatcaagact cttaatgttg gttctatggc tcactcaaca   840
ggtaaaacat tggtcaatac cgttttgtct atggacaaag aagacgttgc tacatttgaa   900
aaaatgcgtg acttgggtgt tgaatttgat gtccgtaaag taccaaatga ttctaaaaaa   960
gatttgtttg acttgattaa caaagccaat gtcaaa                             996

<210>   398
<211>   332
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, mannose-specific IIAB components (manL)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902305 (0.E+01)

<400>   398
Met Thr Ile Met Ser Ile Gly Ile Ile Ile Ala Ser His Gly Glu Phe 
1               5                   10                  15      

Ala Ala Gly Ile His Gln Ser Gly Ser Met Ile Phe Gly Glu Gln Glu 
            20                  25                  30          

Lys Val Gln Val Val Thr Phe Met Pro Asn Glu Gly Pro Asp Asp Leu 
        35                  40                  45              

Tyr Ala Lys Phe Asn Asn Ala Val Ala Ala Phe Asp Ala Glu Asp Glu 
    50                  55                  60                  

Val Leu Val Leu Ala Asp Leu Trp Ser Gly Ser Pro Phe Asn Gln Ala 
65                  70                  75                  80  

Ser Arg Val Met Gly Glu Asn Pro Glu Arg Lys Phe Ala Ile Ile Thr 
                85                  90                  95      

Gly Leu Asn Leu Pro Met Leu Ile Gln Ala Tyr Thr Glu Arg Leu Met 
            100                 105                 110         

Asp Ala Ala Ala Gly Val Glu Lys Val Ala Ala Asn Ile Ile Lys Glu 
        115                 120                 125             

Ala Lys Asp Gly Ile Lys Ala Leu Pro Glu Glu Leu Asn Pro Val Glu 
    130                 135                 140                 

Glu Val Ala Ser Ala Ala Ala Ala Pro Val Ala Gln Thr Ala Ile Pro 
145                 150                 155                 160 

Glu Gly Thr Val Ile Gly Asp Gly Lys Leu Lys Ile Asn Leu Ala Arg 
                165                 170                 175     

Leu Asp Thr Arg Leu Leu His Gly Gln Val Ala Thr Ala Trp Thr Pro 
            180                 185                 190         

Asp Ser Lys Ala Asn Arg Ile Ile Val Ala Ser Asp Asn Val Ala Lys 
        195                 200                 205             

Asp Asp Leu Arg Lys Glu Leu Ile Lys Gln Ala Ala Pro Gly Asn Val 
    210                 215                 220                 

Lys Ala Asn Val Val Pro Ile Gln Lys Leu Ile Glu Ile Ser Lys Asp 
225                 230                 235                 240 

Pro Arg Phe Gly Glu Thr His Ala Leu Ile Leu Phe Glu Thr Pro Gln 
                245                 250                 255     

Asp Ala Leu Arg Ala Ile Glu Gly Gly Val Pro Ile Lys Thr Leu Asn 
            260                 265                 270         

Val Gly Ser Met Ala His Ser Thr Gly Lys Thr Leu Val Asn Thr Val 
        275                 280                 285             

Leu Ser Met Asp Lys Glu Asp Val Ala Thr Phe Glu Lys Met Arg Asp 
    290                 295                 300                 

Leu Gly Val Glu Phe Asp Val Arg Lys Val Pro Asn Asp Ser Lys Lys 
305                 310                 315                 320 

Asp Leu Phe Asp Leu Ile Asn Lys Ala Asn Val Lys 
                325                 330         

<210>   399
<211>   1017
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   399
atgaaagctg ttgttgtaaa tccagaaagc actggtgttg ctattgaaga aaaagtactc   60
cgtccacttg aaactgggga agcacttgta gaagttgaat actgtggcgt ttgccacacc   120
gacctccacg ttgctcatgg tgactttggt caagtcccag gacgtgttct tgggcacgaa   180
ggtatcggta tcgttaaaga gattgctcca gatgtgaaaa gccttaaagt cggtgaccgc   240
gtcagcgttg cttggttctt tgaaggatgt ggcacttgcg aatactgtac aactggtcgc   300
gaaacccttt gccgtacagt gaaaaatgct ggctactcag tagacggtgg tatggctgaa   360
caatgtatcg taactgctga ctatgctgtc aaagttcctg acggacttga tccagcccaa   420
gcttcttcta tcacatgtgc tggagtaaca acctataaag ctatcaaaga agcaaaagtt   480
gaaccaggcc aatgggttgt tctttacggt gctggtggac ttggtaacct cgctgttcaa   540
tacgctaaaa aagtattcaa tgctcatgtt atcgcagtcg atatcaacaa tgacaaactt   600
gcccttgcaa aagaagtagg cgctgacatt gtgattaacg gcctcgaagt tgaagatgta   660
gctggactca ttaaagaaaa aactgatgga ggagctcatt cagctgtcgt aactgctgtg   720
tctaaagttg ccttcaacca ggctgttgac tccattcgtg ctggtggtcg cgtcgtcgct   780
gttggtcttc cttctgaaat gatggaactc agcatcgtta aaacagtcct cgatggaatc   840
caagtcatcg gttctcttgt cggaactcgt aaagacttag aagaagcctt ccaatttggt   900
gcagaaggtc tggtagtccc agttgttcaa aaacgtccag tagaagatgc tgttgccatt   960
ttcgacgaaa tggaaaaagg ccaaatccaa ggacgtatgg tactcgactt cacccac      1017

<210>   400
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alcohol dehydrogenase, zinc-containing
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902306 (0.E+01)

<400>   400
Met Lys Ala Val Val Val Asn Pro Glu Ser Thr Gly Val Ala Ile Glu 
1               5                   10                  15      

Glu Lys Val Leu Arg Pro Leu Glu Thr Gly Glu Ala Leu Val Glu Val 
            20                  25                  30          

Glu Tyr Cys Gly Val Cys His Thr Asp Leu His Val Ala His Gly Asp 
        35                  40                  45              

Phe Gly Gln Val Pro Gly Arg Val Leu Gly His Glu Gly Ile Gly Ile 
    50                  55                  60                  

Val Lys Glu Ile Ala Pro Asp Val Lys Ser Leu Lys Val Gly Asp Arg 
65                  70                  75                  80  

Val Ser Val Ala Trp Phe Phe Glu Gly Cys Gly Thr Cys Glu Tyr Cys 
                85                  90                  95      

Thr Thr Gly Arg Glu Thr Leu Cys Arg Thr Val Lys Asn Ala Gly Tyr 
            100                 105                 110         

Ser Val Asp Gly Gly Met Ala Glu Gln Cys Ile Val Thr Ala Asp Tyr 
        115                 120                 125             


Ala Val Lys Val Pro Asp Gly Leu Asp Pro Ala Gln Ala Ser Ser Ile 
    130                 135                 140                 

Thr Cys Ala Gly Val Thr Thr Tyr Lys Ala Ile Lys Glu Ala Lys Val 
145                 150                 155                 160 

Glu Pro Gly Gln Trp Val Val Leu Tyr Gly Ala Gly Gly Leu Gly Asn 
                165                 170                 175     

Leu Ala Val Gln Tyr Ala Lys Lys Val Phe Asn Ala His Val Ile Ala 
            180                 185                 190         

Val Asp Ile Asn Asn Asp Lys Leu Ala Leu Ala Lys Glu Val Gly Ala 
        195                 200                 205             

Asp Ile Val Ile Asn Gly Leu Glu Val Glu Asp Val Ala Gly Leu Ile 
    210                 215                 220                 

Lys Glu Lys Thr Asp Gly Gly Ala His Ser Ala Val Val Thr Ala Val 
225                 230                 235                 240 

Ser Lys Val Ala Phe Asn Gln Ala Val Asp Ser Ile Arg Ala Gly Gly 
                245                 250                 255     

Arg Val Val Ala Val Gly Leu Pro Ser Glu Met Met Glu Leu Ser Ile 
            260                 265                 270         

Val Lys Thr Val Leu Asp Gly Ile Gln Val Ile Gly Ser Leu Val Gly 
        275                 280                 285             

Thr Arg Lys Asp Leu Glu Glu Ala Phe Gln Phe Gly Ala Glu Gly Leu 
    290                 295                 300                 

Val Val Pro Val Val Gln Lys Arg Pro Val Glu Asp Ala Val Ala Ile 
305                 310                 315                 320 

Phe Asp Glu Met Glu Lys Gly Gln Ile Gln Gly Arg Met Val Leu Asp 
                325                 330                 335     

Phe Thr His 
            

<210>   401
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   401
atgaagctga cgtggtttga agagattttc gaagagtatg accagcttgc aagctggtct   60
ttgtgctctt ttcacagtct catcaaccag ttaatcgatt gttctacttt ttgtctccaa   120
aaccttggaa aaggctttct tttg                                          144

<210>   402
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   402
Met Lys Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr Asp Gln Leu 
1               5                   10                  15      

Ala Ser Trp Ser Leu Cys Ser Phe His Ser Leu Ile Asn Gln Leu Ile 
            20                  25                  30          

Asp Cys Ser Thr Phe Cys Leu Gln Asn Leu Gly Lys Gly Phe Leu Leu 
        35                  40                  45              


<210>   403
<211>   810
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   403
atgacgaaaa aaattattgc agttgacctg gatggaaccc tgctcaactc agacagtcaa   60
atttctgact ttaccaaaag aaccatcaaa aaagttgctg aaaaaggcca tcaggttatt   120
attacgacag gtcgccctta ccgtatgtca aaagattttt accgtgaact gggcttagac   180
actcctatga ttaacttcaa cggatccctt actcatttac cagaccaagt ttgggatttt   240
gaaaagtgtt tgactgtaga caaaaaatat ctgctagata tggttcaacg ttcagaggac   300
attcaagccg attttatcgc tggagaatat cgtaaaaaat tctacattac aaatcccaat   360
gaagaaattg ccaatcccaa actatttggt gtagaagctt tccagcctga agatcaattc   420
cagcctgaat tggtgaccaa ggaccctaac tgtatcctct tgcagactag agccagtgac   480
aaatattcct tggcaaaaga aatgaacgcc ttctaccagc atcaactttc tatcaatacc   540
tggggaggtc cgctcaatat ccttgaatgt accccaaaag gtgtcaacaa ggcctttgct   600
ttggactact tgctcaagat aatgaatcgt gacaaaaaag atttgattgc ctttggagat   660
gaacacaatg ataccgaaat gctcgctttt gctgggaagg gttatgccat gaaaaatgcc   720
aatccagagc tactccctta tgcagatgag caaatttccc ttaccaacga ccaagatggg   780
gttgccaaaa ccctacaaga cttattctta                                    810

<210>   404
<211>   270
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Cof family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902307 (e-156)

<400>   404
Met Thr Lys Lys Ile Ile Ala Val Asp Leu Asp Gly Thr Leu Leu Asn 
1               5                   10                  15      

Ser Asp Ser Gln Ile Ser Asp Phe Thr Lys Arg Thr Ile Lys Lys Val 
            20                  25                  30          

Ala Glu Lys Gly His Gln Val Ile Ile Thr Thr Gly Arg Pro Tyr Arg 
        35                  40                  45              

Met Ser Lys Asp Phe Tyr Arg Glu Leu Gly Leu Asp Thr Pro Met Ile 
    50                  55                  60                  

Asn Phe Asn Gly Ser Leu Thr His Leu Pro Asp Gln Val Trp Asp Phe 
65                  70                  75                  80  

Glu Lys Cys Leu Thr Val Asp Lys Lys Tyr Leu Leu Asp Met Val Gln 
                85                  90                  95      

Arg Ser Glu Asp Ile Gln Ala Asp Phe Ile Ala Gly Glu Tyr Arg Lys 
            100                 105                 110         

Lys Phe Tyr Ile Thr Asn Pro Asn Glu Glu Ile Ala Asn Pro Lys Leu 
        115                 120                 125             

Phe Gly Val Glu Ala Phe Gln Pro Glu Asp Gln Phe Gln Pro Glu Leu 
    130                 135                 140                 

Val Thr Lys Asp Pro Asn Cys Ile Leu Leu Gln Thr Arg Ala Ser Asp 
145                 150                 155                 160 

Lys Tyr Ser Leu Ala Lys Glu Met Asn Ala Phe Tyr Gln His Gln Leu 
                165                 170                 175     

Ser Ile Asn Thr Trp Gly Gly Pro Leu Asn Ile Leu Glu Cys Thr Pro 
            180                 185                 190         

Lys Gly Val Asn Lys Ala Phe Ala Leu Asp Tyr Leu Leu Lys Ile Met 
        195                 200                 205             

Asn Arg Asp Lys Lys Asp Leu Ile Ala Phe Gly Asp Glu His Asn Asp 
    210                 215                 220                 

Thr Glu Met Leu Ala Phe Ala Gly Lys Gly Tyr Ala Met Lys Asn Ala 
225                 230                 235                 240 

Asn Pro Glu Leu Leu Pro Tyr Ala Asp Glu Gln Ile Ser Leu Thr Asn 
                245                 250                 255     

Asp Gln Asp Gly Val Ala Lys Thr Leu Gln Asp Leu Phe Leu 
            260                 265                 270 

<210>   405
<211>   1470
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   405
atgataaatg atataattct attattgttc gtaaaaatta aaaggagatt gatgatggac   60
aaattattta aactaaaaga gaacggtaca gacgttcgta cagaggttct cgctggttta   120
acaactttct ttgcaatgag ctatattctc tttgtaaacc cacaaatact ttcacaaaca   180
ggaatgcctg ctcagggcgt cttcctagcg acgattattg gtgcagtagc gggtaccttg   240
atgatggctt tttatgctaa cttaccttat gcccaagcgc caggtatggg actcaatgcc   300
ttctttacct ttacagttgt attcgggctt ggttattctt ggcaagaagc cctagctatg   360
gtcttcatct gtgggattat ttcattgatt attaccttga caaatgttcg taaaatgatc   420
attgaatcga ttcccaatgc tcttcgctca gctatttcag ctggtatcgg tgtcttcctt   480
gcctatgtag ggattaagaa tgctggactt ttgaaattca cgattgatcc aggcaactat   540
actgttgtag gagaaggggc tgacaaagct caagcaacga ttgcagcaaa ctcttcagca   600
gttccaggat tggtcagctt taataatcca gctgttttag tggctcttgc aggacttgcc   660
attactatct tctttgtcat caaagggatt aaagggggaa ttattctctc tatcttgaca   720
acaactgttc ttgctattgc agttggtttg gttgatttgt ctagtatcga ttttgctaat   780
aaccatgttg gtgcagcttt tgaagatttg aagacaatct ttggtgcagc tcttggttca   840
gaaggattgg gagctttggt ttcagataca gctcgcttgc ctgaaactct gatggccatt   900
cttgccttct cattgacaga tatttttgac acaattggta ccttgatcgg tacaggtgaa   960
aaagttggta tcgtagcgac aaatggtgaa aatcaccaat cagccaaatt ggataaggct   1020
ctttactctg atttgattgg aacgacagtc ggtgccattg caggtacttc aaacgtaacg   1080
acttatgttg agtctgctgc tggtatcggt gcaggtggac gtactggttt gacagccttg   1140
gttgtagcta tctgttttgc gatttcaagc ttctttagcc cacttctagc gatcgtacca   1200
acagcggcta cagctccaat cttgattatc gttgggatta tgatgcttgg tagcttgaaa   1260
aatatccatt gggatgatat gtctgaagca gttcctgcct tcttcacatc tatctttatg   1320
ggattcagct actctatcac tcaagggatt gcagttggtt tcttgactta cactttgact   1380
aagcttgtta aaggtcaagt taaagatgtt catgtcatga tttggatttt ggatgccttg   1440
tttatcctta actacatcag catggcctta                                    1470

<210>   406
<211>   490
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   xanthine/uracil permease family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902308 (0.E+01)

<400>   406
Met Ile Asn Asp Ile Ile Leu Leu Leu Phe Val Lys Ile Lys Arg Arg 
1               5                   10                  15      

Leu Met Met Asp Lys Leu Phe Lys Leu Lys Glu Asn Gly Thr Asp Val 
            20                  25                  30          

Arg Thr Glu Val Leu Ala Gly Leu Thr Thr Phe Phe Ala Met Ser Tyr 
        35                  40                  45              

Ile Leu Phe Val Asn Pro Gln Ile Leu Ser Gln Thr Gly Met Pro Ala 
    50                  55                  60                  

Gln Gly Val Phe Leu Ala Thr Ile Ile Gly Ala Val Ala Gly Thr Leu 
65                  70                  75                  80  

Met Met Ala Phe Tyr Ala Asn Leu Pro Tyr Ala Gln Ala Pro Gly Met 
                85                  90                  95      

Gly Leu Asn Ala Phe Phe Thr Phe Thr Val Val Phe Gly Leu Gly Tyr 
            100                 105                 110         

Ser Trp Gln Glu Ala Leu Ala Met Val Phe Ile Cys Gly Ile Ile Ser 
        115                 120                 125             

Leu Ile Ile Thr Leu Thr Asn Val Arg Lys Met Ile Ile Glu Ser Ile 
    130                 135                 140                 

Pro Asn Ala Leu Arg Ser Ala Ile Ser Ala Gly Ile Gly Val Phe Leu 
145                 150                 155                 160 

Ala Tyr Val Gly Ile Lys Asn Ala Gly Leu Leu Lys Phe Thr Ile Asp 
                165                 170                 175     

Pro Gly Asn Tyr Thr Val Val Gly Glu Gly Ala Asp Lys Ala Gln Ala 
            180                 185                 190         

Thr Ile Ala Ala Asn Ser Ser Ala Val Pro Gly Leu Val Ser Phe Asn 
        195                 200                 205             

Asn Pro Ala Val Leu Val Ala Leu Ala Gly Leu Ala Ile Thr Ile Phe 
    210                 215                 220                 

Phe Val Ile Lys Gly Ile Lys Gly Gly Ile Ile Leu Ser Ile Leu Thr 
225                 230                 235                 240 

Thr Thr Val Leu Ala Ile Ala Val Gly Leu Val Asp Leu Ser Ser Ile 
                245                 250                 255     

Asp Phe Ala Asn Asn His Val Gly Ala Ala Phe Glu Asp Leu Lys Thr 
            260                 265                 270         

Ile Phe Gly Ala Ala Leu Gly Ser Glu Gly Leu Gly Ala Leu Val Ser 
        275                 280                 285             

Asp Thr Ala Arg Leu Pro Glu Thr Leu Met Ala Ile Leu Ala Phe Ser 
    290                 295                 300                 

Leu Thr Asp Ile Phe Asp Thr Ile Gly Thr Leu Ile Gly Thr Gly Glu 
305                 310                 315                 320 

Lys Val Gly Ile Val Ala Thr Asn Gly Glu Asn His Gln Ser Ala Lys 
                325                 330                 335     

Leu Asp Lys Ala Leu Tyr Ser Asp Leu Ile Gly Thr Thr Val Gly Ala 
            340                 345                 350         

Ile Ala Gly Thr Ser Asn Val Thr Thr Tyr Val Glu Ser Ala Ala Gly 
        355                 360                 365             

Ile Gly Ala Gly Gly Arg Thr Gly Leu Thr Ala Leu Val Val Ala Ile 
    370                 375                 380                 

Cys Phe Ala Ile Ser Ser Phe Phe Ser Pro Leu Leu Ala Ile Val Pro 
385                 390                 395                 400 

Thr Ala Ala Thr Ala Pro Ile Leu Ile Ile Val Gly Ile Met Met Leu 
                405                 410                 415     

Gly Ser Leu Lys Asn Ile His Trp Asp Asp Met Ser Glu Ala Val Pro 
            420                 425                 430         

Ala Phe Phe Thr Ser Ile Phe Met Gly Phe Ser Tyr Ser Ile Thr Gln 
        435                 440                 445             

Gly Ile Ala Val Gly Phe Leu Thr Tyr Thr Leu Thr Lys Leu Val Lys 
    450                 455                 460                 

Gly Gln Val Lys Asp Val His Val Met Ile Trp Ile Leu Asp Ala Leu 
465                 470                 475                 480 

Phe Ile Leu Asn Tyr Ile Ser Met Ala Leu 
                485                 490 

<210>   407

<211>   690
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   407
atgtggaaag aattgttgaa tcgtgcaggc tggattttgg tctttttact tgccgtcctt   60
ttatatcagg ttcccctagt ggttacctct attttgactt taaaagaagt agccctgcta   120
cagtcagggc tgatagttgc tggcctttca attgtggttc tggctctatt tattatggga   180
gctcgtaaaa ccaagttagc tagttttaat ttttcttttt ttagagctaa agatttggca   240
cgtttgggct tgagttatct agttattgtc gggtcaaata tacttggttc cattttattg   300
caactgtcaa atgagacgac aacagctaac cagtctcaga ttaatgatat ggttcaaaat   360

agttcgttga tttccagttt cttcttgcta gccttgcttg ctccgatttg tgaggaaatc   420
ttgtgtcgtg ggattgttcc taaaaagatt ttccgaggca aggagaactt gggatttgta   480
gtcggtacga ttgtgtttgc tttattgcat caaccaagta atttaccttc tttattgatt   540
tatggaggta tgtcgacagt tctatcttgg acagcctaca agacccaacg tttggaaatg   600
tcgatcttgc ttcacatgat tgttaatggg attgctttct gtttgttggc tcttgtggtg   660
attatgagtc ggacattagg aatttctgtt                                    690

<210>   408
<211>   230
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902309 (e-124)

<400>   408
Met Trp Lys Glu Leu Leu Asn Arg Ala Gly Trp Ile Leu Val Phe Leu 
1               5                   10                  15      

Leu Ala Val Leu Leu Tyr Gln Val Pro Leu Val Val Thr Ser Ile Leu 
            20                  25                  30          

Thr Leu Lys Glu Val Ala Leu Leu Gln Ser Gly Leu Ile Val Ala Gly 
        35                  40                  45              

Leu Ser Ile Val Val Leu Ala Leu Phe Ile Met Gly Ala Arg Lys Thr 
    50                  55                  60                  

Lys Leu Ala Ser Phe Asn Phe Ser Phe Phe Arg Ala Lys Asp Leu Ala 
65                  70                  75                  80  

Arg Leu Gly Leu Ser Tyr Leu Val Ile Val Gly Ser Asn Ile Leu Gly 
                85                  90                  95      

Ser Ile Leu Leu Gln Leu Ser Asn Glu Thr Thr Thr Ala Asn Gln Ser 
            100                 105                 110         

Gln Ile Asn Asp Met Val Gln Asn Ser Ser Leu Ile Ser Ser Phe Phe 
        115                 120                 125             

Leu Leu Ala Leu Leu Ala Pro Ile Cys Glu Glu Ile Leu Cys Arg Gly 
    130                 135                 140                 

Ile Val Pro Lys Lys Ile Phe Arg Gly Lys Glu Asn Leu Gly Phe Val 
145                 150                 155                 160 

Val Gly Thr Ile Val Phe Ala Leu Leu His Gln Pro Ser Asn Leu Pro 
                165                 170                 175     

Ser Leu Leu Ile Tyr Gly Gly Met Ser Thr Val Leu Ser Trp Thr Ala 
            180                 185                 190         

Tyr Lys Thr Gln Arg Leu Glu Met Ser Ile Leu Leu His Met Ile Val 
        195                 200                 205             

Asn Gly Ile Ala Phe Cys Leu Leu Ala Leu Val Val Ile Met Ser Arg 
    210                 215                 220                 

Thr Leu Gly Ile Ser Val 
225                 230 

<210>   409
<211>   972
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   409
atgatgaaaa tccttgaggg agtgaccgat atgtcaagta aagccaatca tgcaaagaca   60
gttatttgcg gaattatcaa tgtaacccca gactcctttt cggacggtgg tcaatttttt   120
gctcttgagc aggcgctcca gcaggctcgt aaattgatag cagaaggagc cagtatgcta   180
gatatcggcg gagaatcgac tcggccggga agtagctatg ttgagataga agaggaaatc   240
cagcgtgttg ttccagtgat caaagcgatt cgcaaggaaa gtgatgtcct catctctatt   300
gatacttgga agagtcaagt agcagaggct gctttggctg ctggtgccga tctagtcaat   360
gatatcactg gtcttatggg tgatgagaaa atggcttatg tggtagctga agcgagagcg   420
aaagtggtca tcatgtttaa cccagttatg gctcgacctc agcatcctag ttcgcttatc   480
ttccctcatt ttggttttgg tcaaaccttt acagaaaaag agttagctga ctttgaaaca   540
ttgccaatcg aagacttgat ggtggctttc tttgaacgag cactagcgag agcggcagaa   600
gctggtattg caccagaaaa tatcctgttg gatccaggaa ttggctttgg tctgaccaag   660
aaagaaaatc tgcttctttt acgggacctg gataaactac atcagaaggg ctatccaatc   720
tttctcggag tgtcgcgcaa gcgatttgtc atcaatatcc tagaggagaa tggttttgaa   780
gtcaatcctg agacagagct tggtttccga aatcgggaca cggcttcggc tcatgtaact   840
agtatcgctg cgagacaggg tgtagaagtg gtgcgcgtgc atgacgtagc tagtcacagg   900
atggcagttg aaattgcctc tgccattcgt ctggctgatg aagcggaaaa tttagattta   960
aaacaatata aa                                                       972

<210>   410
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydropteroate synthase
<223>   Similar to strain R6 sequence 15902310 (e-171)

<400>   410
Met Met Lys Ile Leu Glu Gly Val Thr Asp Met Ser Ser Lys Ala Asn 
1               5                   10                  15      

His Ala Lys Thr Val Ile Cys Gly Ile Ile Asn Val Thr Pro Asp Ser 
            20                  25                  30          

Phe Ser Asp Gly Gly Gln Phe Phe Ala Leu Glu Gln Ala Leu Gln Gln 
        35                  40                  45              

Ala Arg Lys Leu Ile Ala Glu Gly Ala Ser Met Leu Asp Ile Gly Gly 
    50                  55                  60                  

Glu Ser Thr Arg Pro Gly Ser Ser Tyr Val Glu Ile Glu Glu Glu Ile 
65                  70                  75                  80  

Gln Arg Val Val Pro Val Ile Lys Ala Ile Arg Lys Glu Ser Asp Val 
                85                  90                  95      

Leu Ile Ser Ile Asp Thr Trp Lys Ser Gln Val Ala Glu Ala Ala Leu 
            100                 105                 110         

Ala Ala Gly Ala Asp Leu Val Asn Asp Ile Thr Gly Leu Met Gly Asp 
        115                 120                 125             

Glu Lys Met Ala Tyr Val Val Ala Glu Ala Arg Ala Lys Val Val Ile 
    130                 135                 140                 

Met Phe Asn Pro Val Met Ala Arg Pro Gln His Pro Ser Ser Leu Ile 
145                 150                 155                 160 

Phe Pro His Phe Gly Phe Gly Gln Thr Phe Thr Glu Lys Glu Leu Ala 
                165                 170                 175     

Asp Phe Glu Thr Leu Pro Ile Glu Asp Leu Met Val Ala Phe Phe Glu 
            180                 185                 190         

Arg Ala Leu Ala Arg Ala Ala Glu Ala Gly Ile Ala Pro Glu Asn Ile 
        195                 200                 205             

Leu Leu Asp Pro Gly Ile Gly Phe Gly Leu Thr Lys Lys Glu Asn Leu 
    210                 215                 220                 

Leu Leu Leu Arg Asp Leu Asp Lys Leu His Gln Lys Gly Tyr Pro Ile 
225                 230                 235                 240 

Phe Leu Gly Val Ser Arg Lys Arg Phe Val Ile Asn Ile Leu Glu Glu 
                245                 250                 255     

Asn Gly Phe Glu Val Asn Pro Glu Thr Glu Leu Gly Phe Arg Asn Arg 
            260                 265                 270         

Asp Thr Ala Ser Ala His Val Thr Ser Ile Ala Ala Arg Gln Gly Val 
        275                 280                 285             

Glu Val Val Arg Val His Asp Val Ala Ser His Arg Met Ala Val Glu 
    290                 295                 300                 

Ile Ala Ser Ala Ile Arg Leu Ala Asp Glu Ala Glu Asn Leu Asp Leu 
305                 310                 315                 320 

Lys Gln Tyr Lys 
                

<210>   411
<211>   1320
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   411
atgaaagaaa ttgaaaacaa tcagtggatt gctaactacc ggacggatca accgcatttt   60
ggcttggaac gaatggtgga actgttagct ttgcgtggca atccccatct caaactcaag   120
gtcctccata tcggagggac taacggcaag ggctcgacta ttgctttttt gaaaaagatg   180
ctagaaaagc tagggttgag agttggcgtg tttagctcgc cctatctcat tcattacaca   240
gaccagatta gcatcaatgg ggaatcgatc tcagaagcga ggctagaagc tctcatggca   300
gactatcagt ctttgctgga gggagaagcg gtcgccaatt tacagggcac aaccgagttt   360
gagattatca cagccctggc ctatgactac tttgcctcag agcaagtaga tgtggccatc   420
atggaagttg gcatgggtgg acttttggat agtaccaatg tctgtcagcc cattttgaca   480
ggaattacaa ctattggctt ggatcatgtg gctctacttg gtgacacctt ggaggtcata   540
gcagagcaga aggcaggtat tatcaaacaa gggatgccct tggtaacagg gcgtattgct   600
ccagaagcct tggctgtgat tgaccgcatt gcggaaggga aagatgcgcc gagacttgcc   660
tacgggacag attatcaggt tcgtcatcaa gaaagtgtgg tgacagggga agtctttgac   720
tatacaagtg ctgtcagaca aggtcgcttc cagactagcc tgcttggttt gtaccaaata   780
gagaatgctg ggatggccat agctttactt gatacttttt gtcaagaaga tggtcgagag   840
ctagcaagca atgattttct tggtcaagcc ttggaagaaa caagttggcc agggcgtttg   900
gaaatcgtgt caagagatcc cttgatgatt ttggatggag cccacaatcc ccatgctatc   960
aaggccttgt tggtaacctt gcaagaacgt tttgcggatt atcataagga aatcctcttc   1020
acttgtatca aaaccaaggc cttggaggat atgttggact tgctgggagc catgccagtt   1080
accgagctta ctctaacaca ttttgcggat agtcgggcga cggatgaaaa cgtgctgaaa   1140
gaggcagcta agtctagaaa tctcagctac caagattggc atgattttct agagcagaat   1200
ttgacagata aaaaagaaga gaaacaaaca gttaggattg tcacaggttc cttgtatttc   1260
ttgagccaag tgagggccta tctgatggag aggaagaacg agaatggata cacaaaagat   1320

<210>   412
<211>   440
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydrofolate synthetase (folC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902311 (0.E+01)

<400>   412
Met Lys Glu Ile Glu Asn Asn Gln Trp Ile Ala Asn Tyr Arg Thr Asp 
1               5                   10                  15      

Gln Pro His Phe Gly Leu Glu Arg Met Val Glu Leu Leu Ala Leu Arg 
            20                  25                  30          

Gly Asn Pro His Leu Lys Leu Lys Val Leu His Ile Gly Gly Thr Asn 
        35                  40                  45              

Gly Lys Gly Ser Thr Ile Ala Phe Leu Lys Lys Met Leu Glu Lys Leu 
    50                  55                  60                  

Gly Leu Arg Val Gly Val Phe Ser Ser Pro Tyr Leu Ile His Tyr Thr 
65                  70                  75                  80  

Asp Gln Ile Ser Ile Asn Gly Glu Ser Ile Ser Glu Ala Arg Leu Glu 
                85                  90                  95      

Ala Leu Met Ala Asp Tyr Gln Ser Leu Leu Glu Gly Glu Ala Val Ala 
            100                 105                 110         

Asn Leu Gln Gly Thr Thr Glu Phe Glu Ile Ile Thr Ala Leu Ala Tyr 
        115                 120                 125             

Asp Tyr Phe Ala Ser Glu Gln Val Asp Val Ala Ile Met Glu Val Gly 
    130                 135                 140                 

Met Gly Gly Leu Leu Asp Ser Thr Asn Val Cys Gln Pro Ile Leu Thr 
145                 150                 155                 160 

Gly Ile Thr Thr Ile Gly Leu Asp His Val Ala Leu Leu Gly Asp Thr 
                165                 170                 175     

Leu Glu Val Ile Ala Glu Gln Lys Ala Gly Ile Ile Lys Gln Gly Met 
            180                 185                 190         

Pro Leu Val Thr Gly Arg Ile Ala Pro Glu Ala Leu Ala Val Ile Asp 
        195                 200                 205             

Arg Ile Ala Glu Gly Lys Asp Ala Pro Arg Leu Ala Tyr Gly Thr Asp 
    210                 215                 220                 

Tyr Gln Val Arg His Gln Glu Ser Val Val Thr Gly Glu Val Phe Asp 
225                 230                 235                 240 

Tyr Thr Ser Ala Val Arg Gln Gly Arg Phe Gln Thr Ser Leu Leu Gly 
                245                 250                 255     

Leu Tyr Gln Ile Glu Asn Ala Gly Met Ala Ile Ala Leu Leu Asp Thr 
            260                 265                 270         

Phe Cys Gln Glu Asp Gly Arg Glu Leu Ala Ser Asn Asp Phe Leu Gly 
        275                 280                 285             

Gln Ala Leu Glu Glu Thr Ser Trp Pro Gly Arg Leu Glu Ile Val Ser 
    290                 295                 300                 

Arg Asp Pro Leu Met Ile Leu Asp Gly Ala His Asn Pro His Ala Ile 
305                 310                 315                 320 

Lys Ala Leu Leu Val Thr Leu Gln Glu Arg Phe Ala Asp Tyr His Lys 
                325                 330                 335     

Glu Ile Leu Phe Thr Cys Ile Lys Thr Lys Ala Leu Glu Asp Met Leu 
            340                 345                 350         

Asp Leu Leu Gly Ala Met Pro Val Thr Glu Leu Thr Leu Thr His Phe 
        355                 360                 365             

Ala Asp Ser Arg Ala Thr Asp Glu Asn Val Leu Lys Glu Ala Ala Lys 
    370                 375                 380                 

Ser Arg Asn Leu Ser Tyr Gln Asp Trp His Asp Phe Leu Glu Gln Asn 
385                 390                 395                 400 

Leu Thr Asp Lys Lys Glu Glu Lys Gln Thr Val Arg Ile Val Thr Gly 
                405                 410                 415     

Ser Leu Tyr Phe Leu Ser Gln Val Arg Ala Tyr Leu Met Glu Arg Lys 
            420                 425                 430         

Asn Glu Asn Gly Tyr Thr Lys Asp 
        435                 440 

<210>   413
<211>   552
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   413
atggatacac aaaagattga agcggctgta aaaatgatta tcgaggctgt aggagaggac   60
gctaatcgcg agggcttgca ggaaacacct gctcgtgtag cccgtatgta tcaagagatt   120
ttttcaggtc ttggtcaaac agcagaggaa catttgtcaa aatcctttga aattattgac   180
gataatatgg tggtagaaaa ggatatcttt ttccatacca tgtgtgaaca ccacttcttg   240
ccattttatg gtagagcgca cattgcctac attccagatg gtcgtgtggc aggcttgtct   300
aagctagccc gtacggttga agtttattcg aaaaaaccac aaattcaaga acgtttgaat   360
atcgaagtgg ccgatgcctt gatggactat ctaggtgcta aaggagcctt tgttgtcatt   420
gaggcggaac atatgtgtat gagtatgcgt ggtgttagaa aaccaggcac tgcaaccttg   480
acgacagtag ctcgtggtct atttgaaaca gataaggatc tccgtgacca agcttatcgt   540
ttaatggggc ta                                                       552

<210>   414
<211>   184
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP cyclohydrolase I (folE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902312 (e-103)

<400>   414
Met Asp Thr Gln Lys Ile Glu Ala Ala Val Lys Met Ile Ile Glu Ala 
1               5                   10                  15      

Val Gly Glu Asp Ala Asn Arg Glu Gly Leu Gln Glu Thr Pro Ala Arg 
            20                  25                  30          

Val Ala Arg Met Tyr Gln Glu Ile Phe Ser Gly Leu Gly Gln Thr Ala 
        35                  40                  45              

Glu Glu His Leu Ser Lys Ser Phe Glu Ile Ile Asp Asp Asn Met Val 
    50                  55                  60                  

Val Glu Lys Asp Ile Phe Phe His Thr Met Cys Glu His His Phe Leu 
65                  70                  75                  80  

Pro Phe Tyr Gly Arg Ala His Ile Ala Tyr Ile Pro Asp Gly Arg Val 
                85                  90                  95      

Ala Gly Leu Ser Lys Leu Ala Arg Thr Val Glu Val Tyr Ser Lys Lys 
            100                 105                 110         

Pro Gln Ile Gln Glu Arg Leu Asn Ile Glu Val Ala Asp Ala Leu Met 
        115                 120                 125             

Asp Tyr Leu Gly Ala Lys Gly Ala Phe Val Val Ile Glu Ala Glu His 
    130                 135                 140                 

Met Cys Met Ser Met Arg Gly Val Arg Lys Pro Gly Thr Ala Thr Leu 
145                 150                 155                 160 

Thr Thr Val Ala Arg Gly Leu Phe Glu Thr Asp Lys Asp Leu Arg Asp 
                165                 170                 175     

Gln Ala Tyr Arg Leu Met Gly Leu 
            180                 

<210>   415
<211>   810
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   415
atggatcaac tgcagattaa ggatttggaa atgtttgcct atcatggtct ttttcctagt   60
gagaaagaat tggggcagaa atttgtcgtt tcagccatcc tatcctatga tatgaccaag   120
gcagctacag acttggattt aacagcctct gtccattacg gagaattgtg tcagcagtgg   180
acgacttggt ttcaggaaac gagtgaagat ttgattgaaa cggtagccta taaactggtg   240
gaacgtacct ttgagtttta tcctcttgtc caagaaatga agttggaact gaaaaaacct   300
tgggcaccgg tgcatttgtc actagatact tgctcggtaa ccattcatcg ccgcaagcaa   360
cgagccttta tcgccctagg aagcaatatg ggagataaac aagcaaactt gaagcaagcc   420
attgacaaac tgcgagctcg tggcatccat attctcaaag agtccagtgt cttagcgacg   480
gagccttggg gtggagtgga gcaggatagc tttgccaatc aagtggttga ggtggaaacc   540
tggctaccag cacaagactt gttagaaacc ttgttagcca ttgagtcaga gctgggacgg   600
gtgagagaag tgcattgggg acctcgtttg attgatttgg acttgctctt tgtggaggac   660
cagatccttt atacagacga cctcatattg cctcatcctt acatagcgga acgccttttt   720
gtccttgagt ccttacagga aattgcgcct cattttatcc atccgatatt aaaacaaccg   780
atccgcaact tgtatgatgc tttgaaaaaa                                    810

<210>   416
<211>   270
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bifunctional folate synthesis protein (sulD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902313 (e-155)

<400>   416
Met Asp Gln Leu Gln Ile Lys Asp Leu Glu Met Phe Ala Tyr His Gly 
1               5                   10                  15      

Leu Phe Pro Ser Glu Lys Glu Leu Gly Gln Lys Phe Val Val Ser Ala 
            20                  25                  30          

Ile Leu Ser Tyr Asp Met Thr Lys Ala Ala Thr Asp Leu Asp Leu Thr 
        35                  40                  45              

Ala Ser Val His Tyr Gly Glu Leu Cys Gln Gln Trp Thr Thr Trp Phe 
    50                  55                  60                  

Gln Glu Thr Ser Glu Asp Leu Ile Glu Thr Val Ala Tyr Lys Leu Val 
65                  70                  75                  80  

Glu Arg Thr Phe Glu Phe Tyr Pro Leu Val Gln Glu Met Lys Leu Glu 
                85                  90                  95      

Leu Lys Lys Pro Trp Ala Pro Val His Leu Ser Leu Asp Thr Cys Ser 
            100                 105                 110         

Val Thr Ile His Arg Arg Lys Gln Arg Ala Phe Ile Ala Leu Gly Ser 
        115                 120                 125             

Asn Met Gly Asp Lys Gln Ala Asn Leu Lys Gln Ala Ile Asp Lys Leu 
    130                 135                 140                 

Arg Ala Arg Gly Ile His Ile Leu Lys Glu Ser Ser Val Leu Ala Thr 
145                 150                 155                 160 

Glu Pro Trp Gly Gly Val Glu Gln Asp Ser Phe Ala Asn Gln Val Val 
                165                 170                 175     

Glu Val Glu Thr Trp Leu Pro Ala Gln Asp Leu Leu Glu Thr Leu Leu 
            180                 185                 190         

Ala Ile Glu Ser Glu Leu Gly Arg Val Arg Glu Val His Trp Gly Pro 
        195                 200                 205             

Arg Leu Ile Asp Leu Asp Leu Leu Phe Val Glu Asp Gln Ile Leu Tyr 
    210                 215                 220                 

Thr Asp Asp Leu Ile Leu Pro His Pro Tyr Ile Ala Glu Arg Leu Phe 
225                 230                 235                 240 

Val Leu Glu Ser Leu Gln Glu Ile Ala Pro His Phe Ile His Pro Ile 
                245                 250                 255     

Leu Lys Gln Pro Ile Arg Asn Leu Tyr Asp Ala Leu Lys Lys 
            260                 265                 270 

<210>   417
<211>   369
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   417
ttgattttta atcctatttg ctgtatgata agggaaaaga aaggggacag agatatggct   60
tttaccaata cccacatgcg atctgctagt tttggtattg ttaccagctt gcctgatgac   120
atcattgact ctttttggta tatcatcgac catttcttaa aaaatgtctt tgaattggaa   180
gaagaactcg agtttcaatt gcttaataac caaggaaaga ttaccttcca cttttcaagt   240
caacacctcc ctacagccat tgattttgac tttaaccatc ctttcgaccc tcgttatccc   300
ccaagagtac tggttttaga catggacggt agagaaacta tcctcctccc agaagaaaat   360
gacctattt                                                           369

<210>   418
<211>   123
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902314 (6.E-71)

<400>   418
Met Ile Phe Asn Pro Ile Cys Cys Met Ile Arg Glu Lys Lys Gly Asp 
1               5                   10                  15      

Arg Asp Met Ala Phe Thr Asn Thr His Met Arg Ser Ala Ser Phe Gly 
            20                  25                  30          

Ile Val Thr Ser Leu Pro Asp Asp Ile Ile Asp Ser Phe Trp Tyr Ile 
        35                  40                  45              

Ile Asp His Phe Leu Lys Asn Val Phe Glu Leu Glu Glu Glu Leu Glu 
    50                  55                  60                  

Phe Gln Leu Leu Asn Asn Gln Gly Lys Ile Thr Phe His Phe Ser Ser 
65                  70                  75                  80  

Gln His Leu Pro Thr Ala Ile Asp Phe Asp Phe Asn His Pro Phe Asp 
                85                  90                  95      

Pro Arg Tyr Pro Pro Arg Val Leu Val Leu Asp Met Asp Gly Arg Glu 
            100                 105                 110         

Thr Ile Leu Leu Pro Glu Glu Asn Asp Leu Phe 
        115                 120             

<210>   419
<211>   444
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   419
atgaacaaaa caacatttat ggctaaacca ggccaagttg aacgtaaatg gtacgtagtt   60
gacgcaactg atgtaccact tggacgtctt tctgcagtag ttgctagcgt acttcgcgga   120
aaaaacaaac caacatttac accacacact gatacaggtg acttcgtgat tgttatcaat   180
gctgaaaaag ttaaattgac tggtaaaaaa gcaactgata aaatctacta cactcactca   240
aaccacccag gtggattgaa acaaatctct gcaggtgaac ttcgttctaa aaatgcagta   300
cgtttgattg agaaatcagt taaaggtatg cttccacaca atacacttgg acgcgctcaa   360
ggtatgaagt tgaaagtatt tgttggagct gagcacactc acgctgcaca acaaccagaa   420
gttcttgaca tttcaggact tatc                                          444

<210>   420
<211>   148
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L13 (rplM)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902315 (2.E-82)

<400>   420
Met Asn Lys Thr Thr Phe Met Ala Lys Pro Gly Gln Val Glu Arg Lys 
1               5                   10                  15      

Trp Tyr Val Val Asp Ala Thr Asp Val Pro Leu Gly Arg Leu Ser Ala 
            20                  25                  30          

Val Val Ala Ser Val Leu Arg Gly Lys Asn Lys Pro Thr Phe Thr Pro 
        35                  40                  45              

His Thr Asp Thr Gly Asp Phe Val Ile Val Ile Asn Ala Glu Lys Val 
    50                  55                  60                  

Lys Leu Thr Gly Lys Lys Ala Thr Asp Lys Ile Tyr Tyr Thr His Ser 
65                  70                  75                  80  

Asn His Pro Gly Gly Leu Lys Gln Ile Ser Ala Gly Glu Leu Arg Ser 
                85                  90                  95      

Lys Asn Ala Val Arg Leu Ile Glu Lys Ser Val Lys Gly Met Leu Pro 
            100                 105                 110         

His Asn Thr Leu Gly Arg Ala Gln Gly Met Lys Leu Lys Val Phe Val 
        115                 120                 125             

Gly Ala Glu His Thr His Ala Ala Gln Gln Pro Glu Val Leu Asp Ile 
    130                 135                 140                 

Ser Gly Leu Ile 
145             

<210>   421
<211>   390
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   421
atgtcacaag cacaatatgc aggtactgga cgtcgtaaaa acgctgttgc acgcgttcgc   60
cttgttccag gaactggtaa aatcactgtt aacaaaaaag atgttgaaga gtacatccca   120
cacgctgacc ttcgtcttgt catcaaccaa ccattcgcag ttacttcaac tgtaggttca   180
tacgacgttt tcgttaacgt tataggtggt ggatacgctg gtcaatcagg agctatccgt   240
cacggtatcg ctcgtgccct tcttcaagta gacccagact tccgcgattc attgaaacgc   300
gcaggacttc ttacacgtga ctcacgtaaa gttgaacgta agaaaccagg tcttaagaaa   360
gctcgtaaag catcacaatt tagtaaacgt                                    390

<210>   422
<211>   130
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S9 (rpsI)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902316 (5.E-70)

<400>   422
Met Ser Gln Ala Gln Tyr Ala Gly Thr Gly Arg Arg Lys Asn Ala Val 
1               5                   10                  15      

Ala Arg Val Arg Leu Val Pro Gly Thr Gly Lys Ile Thr Val Asn Lys 
            20                  25                  30          

Lys Asp Val Glu Glu Tyr Ile Pro His Ala Asp Leu Arg Leu Val Ile 
        35                  40                  45              

Asn Gln Pro Phe Ala Val Thr Ser Thr Val Gly Ser Tyr Asp Val Phe 
    50                  55                  60                  

Val Asn Val Ile Gly Gly Gly Tyr Ala Gly Gln Ser Gly Ala Ile Arg 
65                  70                  75                  80  

His Gly Ile Ala Arg Ala Leu Leu Gln Val Asp Pro Asp Phe Arg Asp 
                85                  90                  95      

Ser Leu Lys Arg Ala Gly Leu Leu Thr Arg Asp Ser Arg Lys Val Glu 
            100                 105                 110         

Arg Lys Lys Pro Gly Leu Lys Lys Ala Arg Lys Ala Ser Gln Phe Ser 
        115                 120                 125             

Lys Arg 
    130 

<210>   423
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   423
atgagcttag aagccatttc tgaagcatta actcatagcg ataccgttac aactaagact   60
tatgttaata cttcaaacat agttccatta tctgctggac aagttgccta ccaacatctt   120
aaaaataag                                                           129

<210>   424
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   424
Met Ser Leu Glu Ala Ile Ser Glu Ala Leu Thr His Ser Asp Thr Val 
1               5                   10                  15      

Thr Thr Lys Thr Tyr Val Asn Thr Ser Asn Ile Val Pro Leu Ser Ala 
            20                  25                  30          


Gly Gln Val Ala Tyr Gln His Leu Lys Asn Lys 
        35                  40              

<210>   425
<211>   147
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   425
ttgaacaacc ttgataatat gcgttttatt atggaaatat ttgcttcatt ttctcctgaa   60
atagagcttt tgctatccta tttttctcta tttctaatga tttacttcaa cttcttacct   120
cttgggaaaa acaacaaaga tatgaac                                       147

<210>   426
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   426
Met Asn Asn Leu Asp Asn Met Arg Phe Ile Met Glu Ile Phe Ala Ser 
1               5                   10                  15      

Phe Ser Pro Glu Ile Glu Leu Leu Leu Ser Tyr Phe Ser Leu Phe Leu 
            20                  25                  30          

Met Ile Tyr Phe Asn Phe Leu Pro Leu Gly Lys Asn Asn Lys Asp Met 
        35                  40                  45              

Asn 
    

<210>   427
<211>   1206
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   427
atgaactata tcaaaagacc acattattta gattttttaa gaaaacatcg tgaccgacca   60
atcatcaaag ttgtgagtgg agttagacga gctggtaaat ctgtgctttt tcaactctat   120
aaagaggagt tactagcaac tggggtagac gaggatcaga ttatattcat caatttcgaa   180
gatttgagtt actatgatct gcgacatttt caaacattat tcgcttatat aaaagatcaa   240
ttagttagca agaaaacata ctatatcttt ttagatgaaa ttcaatatgt tgaaaaattt   300
gaactggtag cagatagtct attcatctta gcaaatgtag acctctattt gactggatct   360
aacgcctact ttatgagtag ccaattagca acaaacttga ctggtcggta tgttgagata   420
gaggttcttc ctttgtcatt tgaagaatat ctatcaggtc aatctctcac agagaatctg   480
aatacaacag aaatttttaa caattatctc tttagtgctt tcccttactt attgcaaaca   540
tcatcttacg atgaaaaaat tgactatctc agaggaatat ataactccat actgttaaat   600
gatattgtca ctagattggg aaaaccaaat cctactatta ttgagcgcat tgtccgaacc   660
cttctcagta gtacaggtag cttaatatca acaaataaga ttcgcaatac cctagtcagc   720
caaaatgttt caatatccca taatactttg gaaaattatt tgacaacttt gacagatagt   780
ttactttttt attccgttcc acgttttgat gtaaaaggta gagcattatt gcaacgttta   840
gaaaaatatt atcccgttga tttaggttta cgacatctct tattaccaga ccagaaagaa   900
gacattaggc atatcttgga aaatatggta tatttggaat tgagacgtag atattcacaa   960
gtatatgttg gtaatttaga taagtatgag gttgattttg ttgttgtaac tgatcttggc   1020
cactacgctt attatcaggt cagtgaaaca acacttgctc cagaaacact agaaagagaa   1080
cttagaccac tagaagccat taaagatcaa ttccctaaat atctattaac aatggatacg   1140
attcagccaa cagccaatta caatggaatc gagaagaaaa gcattataga ttggttacta   1200
gaaaaa                                                              1206

<210>   428
<211>   402
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm

<400>   428
Met Asn Tyr Ile Lys Arg Pro His Tyr Leu Asp Phe Leu Arg Lys His 
1               5                   10                  15      

Arg Asp Arg Pro Ile Ile Lys Val Val Ser Gly Val Arg Arg Ala Gly 
            20                  25                  30          

Lys Ser Val Leu Phe Gln Leu Tyr Lys Glu Glu Leu Leu Ala Thr Gly 
        35                  40                  45              

Val Asp Glu Asp Gln Ile Ile Phe Ile Asn Phe Glu Asp Leu Ser Tyr 
    50                  55                  60                  

Tyr Asp Leu Arg His Phe Gln Thr Leu Phe Ala Tyr Ile Lys Asp Gln 
65                  70                  75                  80  

Leu Val Ser Lys Lys Thr Tyr Tyr Ile Phe Leu Asp Glu Ile Gln Tyr 
                85                  90                  95      

Val Glu Lys Phe Glu Leu Val Ala Asp Ser Leu Phe Ile Leu Ala Asn 
            100                 105                 110         

Val Asp Leu Tyr Leu Thr Gly Ser Asn Ala Tyr Phe Met Ser Ser Gln 
        115                 120                 125             

Leu Ala Thr Asn Leu Thr Gly Arg Tyr Val Glu Ile Glu Val Leu Pro 
    130                 135                 140                 

Leu Ser Phe Glu Glu Tyr Leu Ser Gly Gln Ser Leu Thr Glu Asn Leu 
145                 150                 155                 160 

Asn Thr Thr Glu Ile Phe Asn Asn Tyr Leu Phe Ser Ala Phe Pro Tyr 
                165                 170                 175     

Leu Leu Gln Thr Ser Ser Tyr Asp Glu Lys Ile Asp Tyr Leu Arg Gly 
            180                 185                 190         

Ile Tyr Asn Ser Ile Leu Leu Asn Asp Ile Val Thr Arg Leu Gly Lys 
        195                 200                 205             

Pro Asn Pro Thr Ile Ile Glu Arg Ile Val Arg Thr Leu Leu Ser Ser 
    210                 215                 220                 

Thr Gly Ser Leu Ile Ser Thr Asn Lys Ile Arg Asn Thr Leu Val Ser 
225                 230                 235                 240 

Gln Asn Val Ser Ile Ser His Asn Thr Leu Glu Asn Tyr Leu Thr Thr 
                245                 250                 255     

Leu Thr Asp Ser Leu Leu Phe Tyr Ser Val Pro Arg Phe Asp Val Lys 
            260                 265                 270         

Gly Arg Ala Leu Leu Gln Arg Leu Glu Lys Tyr Tyr Pro Val Asp Leu 
        275                 280                 285             

Gly Leu Arg His Leu Leu Leu Pro Asp Gln Lys Glu Asp Ile Arg His 
    290                 295                 300                 

Ile Leu Glu Asn Met Val Tyr Leu Glu Leu Arg Arg Arg Tyr Ser Gln 
305                 310                 315                 320 

Val Tyr Val Gly Asn Leu Asp Lys Tyr Glu Val Asp Phe Val Val Val 
                325                 330                 335     

Thr Asp Leu Gly His Tyr Ala Tyr Tyr Gln Val Ser Glu Thr Thr Leu 
            340                 345                 350         

Ala Pro Glu Thr Leu Glu Arg Glu Leu Arg Pro Leu Glu Ala Ile Lys 
        355                 360                 365             

Asp Gln Phe Pro Lys Tyr Leu Leu Thr Met Asp Thr Ile Gln Pro Thr 
    370                 375                 380                 

Ala Asn Tyr Asn Gly Ile Glu Lys Lys Ser Ile Ile Asp Trp Leu Leu 
385                 390                 395                 400 

Glu Lys 
        

<210>   429
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   429
atgtggtata atcttcttat ggcatattca atagattttc gtaaaaaagt tctctcttat   60
tgtgagcgaa caggtagtat aacagaagca tcacacgttt tccaaatctc acgtaatacc   120
atttatggct ggttaaagct aaaagagaaa acaggagagc taaaccacca agtaaaagga   180
acaaaaccaa gaaaagttga tagagataga cttaaaaact atcttactga caatccagat   240
gcttatttga ctgaaatagc ttctgaattt ggctgtcatc caactaccat ccactatgcg   300
ctcaaagcta tgggctacac tcgaaaaaaa gaaccacacc tacta                   345

<210>   430
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1 FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903081 (1.E-62)

<400>   430
Met Trp Tyr Asn Leu Leu Met Ala Tyr Ser Ile Asp Phe Arg Lys Lys 
1               5                   10                  15      

Val Leu Ser Tyr Cys Glu Arg Thr Gly Ser Ile Thr Glu Ala Ser His 
            20                  25                  30          

Val Phe Gln Ile Ser Arg Asn Thr Ile Tyr Gly Trp Leu Lys Leu Lys 
        35                  40                  45              

Glu Lys Thr Gly Glu Leu Asn His Gln Val Lys Gly Thr Lys Pro Arg 
    50                  55                  60                  

Lys Val Asp Arg Asp Arg Leu Lys Asn Tyr Leu Thr Asp Asn Pro Asp 
65                  70                  75                  80  


Ala Tyr Leu Thr Glu Ile Ala Ser Glu Phe Gly Cys His Pro Thr Thr 
                85                  90                  95      

Ile His Tyr Ala Leu Lys Ala Met Gly Tyr Thr Arg Lys Lys Glu Pro 
            100                 105                 110         

His Leu Leu 
        115 

<210>   431
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   431
ttggttgcag gtctaacaaa tggtgagtta atcgctccaa tgacttacga agagacgatg   60
acgagcgact tttttgaagc ttggtttcag aagtttctct taccaacatt aaccacacca   120
tcggttatta ttatggataa tgcaagattc catagaatgg ggaagctaga actcttgtgt   180
gaagagtttg ggtataaact tttacctctt cctccctact cacctgagta caatcctatt   240
gagaaaacat gggctcatat caaaaagcac ctcaaaaagg tattaccaag ttgcaatacc   300
ttttatgagg ctcttttgtc ctgctcttgt ttcaat                             336

<210>   432
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903081 (1.E-63)

<400>   432
Met Val Ala Gly Leu Thr Asn Gly Glu Leu Ile Ala Pro Met Thr Tyr 
1               5                   10                  15      

Glu Glu Thr Met Thr Ser Asp Phe Phe Glu Ala Trp Phe Gln Lys Phe 
            20                  25                  30          

Leu Leu Pro Thr Leu Thr Thr Pro Ser Val Ile Ile Met Asp Asn Ala 
        35                  40                  45              

Arg Phe His Arg Met Gly Lys Leu Glu Leu Leu Cys Glu Glu Phe Gly 
    50                  55                  60                  

Tyr Lys Leu Leu Pro Leu Pro Pro Tyr Ser Pro Glu Tyr Asn Pro Ile 
65                  70                  75                  80  

Glu Lys Thr Trp Ala His Ile Lys Lys His Leu Lys Lys Val Leu Pro 
                85                  90                  95      

Ser Cys Asn Thr Phe Tyr Glu Ala Leu Leu Ser Cys Ser Cys Phe Asn 
            100                 105                 110         


<210>   433
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   433
ttgtttcaat tgactataaa tcgctataag aaaaaatcat tttattggta taaagaagtg   60
attgaaagta atggcgaaac gttagataat                                    90

<210>   434
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl hydrolase, family 1, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902318 (9.E-14)

<400>   434
Met Phe Gln Leu Thr Ile Asn Arg Tyr Lys Lys Lys Ser Phe Tyr Trp 
1               5                   10                  15      

Tyr Lys Glu Val Ile Glu Ser Asn Gly Glu Thr Leu Asp Asn 
            20                  25                  30  

<210>   435
<211>   363
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   435
ttgaaggatg attttggagg atataagatg acattgacta ttcatgtata ttataaaggt   60
gatggagata gtgcaataaa gtttgcaaga gaaatgcttg atagtggcct tgttaaagaa   120
attagaaatc aaaaaggtaa cttgaaatac gaatattttt taccaattga aaaagaggga   180
actattctcc ttattgatca gtggataaat caagaaactt tagataaaca ttatcaatca   240
aagacaatgc agaaaatctt agatttaaga aaaaaatatc acttgcagat gcaagttgaa   300
cgttatatag aagatgattc tgggatgcca gaaagcgata agtcgtttat agacacaggg   360
aat                                                                 363

<210>   436
<211>   121
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902319 (3.E-66)

<400>   436
Met Lys Asp Asp Phe Gly Gly Tyr Lys Met Thr Leu Thr Ile His Val 

1               5                   10                  15      

Tyr Tyr Lys Gly Asp Gly Asp Ser Ala Ile Lys Phe Ala Arg Glu Met 
            20                  25                  30          

Leu Asp Ser Gly Leu Val Lys Glu Ile Arg Asn Gln Lys Gly Asn Leu 
        35                  40                  45              

Lys Tyr Glu Tyr Phe Leu Pro Ile Glu Lys Glu Gly Thr Ile Leu Leu 
    50                  55                  60                  

Ile Asp Gln Trp Ile Asn Gln Glu Thr Leu Asp Lys His Tyr Gln Ser 
65                  70                  75                  80  

Lys Thr Met Gln Lys Ile Leu Asp Leu Arg Lys Lys Tyr His Leu Gln 
                85                  90                  95      

Met Gln Val Glu Arg Tyr Ile Glu Asp Asp Ser Gly Met Pro Glu Ser 
            100                 105                 110         

Asp Lys Ser Phe Ile Asp Thr Gly Asn 
        115                 120     

<210>   437
<211>   1434
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   437
atgactactt ttaaagatgg atttttatgg ggtggtgctg ttgctgctca tcaacttgaa   60
ggtggatggc aagaaggtgg caagggaatt agtgttgctg atgttatgac tgctggtcgt   120
catggagtag ctcgtgaaat tactttggga gttttagagg gtaaatatta tccaaatcat   180
gaggcgatag atttttatca ccgttataaa gaagatatag cactttttgc tgaaatggga   240
ttcaagtgct tccgtacctc tattgcatgg acacgtatct ttccaaaagg tgatgagtta   300
gagccgaatg aagaaggatt acagttttat gataatcttt ttgatgaatg cttaaagaat   360
ggtattgaac ctgtcatcac tctatctcat tttgaaatgc cttatcactt agtgaccgaa   420
tatggtggtt ggaaaaatag gaaattgatt gatttctttg ctcgttttgc agaagtcgta   480
tttaaacgtt acaaagataa ggttaaatat tggatgactt tcaatgaaat caataatcaa   540
gcgaattatc aggaagattt tgcaccattt actaactcag gtattgtata tgaggaaggt   600
gataatagag aagcaattat gtatcaagca gcacattacg aattagttgc ttctgcacga   660
gctgtaaaaa ttggtcatga gattaatcca gattttcaaa taggttgtat gattgcgatg   720
tgtccaattt atccagttac ttgcaatcct aaggatatct taatggcaat gaaagctatg   780
cagaagcgtt attattttgc tgatgtgcat gttttaggta aatatcctga gcatattttc   840
aagtattggg aacgaaaagg tatttcagtt gattttactg cccaggataa agaagattta   900
cttggtggga ctgtagatta cattggtttc agttactata tgtcctttgc tatcgactct   960
catcgtgaaa ataatcctta ttttgattat cttgaaacag aagatttagt gaaaaataat   1020
tatgttaagg cttctgaatg ggagtggcaa attgatccag aaggtttgcg ttatgcgtta   1080
aattggttta cagaccacta tcacttacca ctctttattg ttgaaaatgg ttttggagct   1140
atagatcaag ttgcagcaga tggtatggta catgatgatt atagaattga atatctaggt   1200
gcccatattc gtgaaatgaa aaaggctgta gttgaagatg gtgttgattt aatgggttat   1260
actccatggg gatgtattga tttggtttca gctggtaccg gtgaaatgcg gaaacgttat   1320
ggctttattt atgtagataa agatgataat gggaagggaa gttataatcg ttccccgaaa   1380
aaatcttttg gctggtataa ggaagttatt tcatctaacg gtgaatcagt agaa         1434

<210>   438
<211>   478
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   6-phospho-beta-glucosidase (bglA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902320 (0.E+01)

<400>   438
Met Thr Thr Phe Lys Asp Gly Phe Leu Trp Gly Gly Ala Val Ala Ala 
1               5                   10                  15      


His Gln Leu Glu Gly Gly Trp Gln Glu Gly Gly Lys Gly Ile Ser Val 
            20                  25                  30          

Ala Asp Val Met Thr Ala Gly Arg His Gly Val Ala Arg Glu Ile Thr 
        35                  40                  45              

Leu Gly Val Leu Glu Gly Lys Tyr Tyr Pro Asn His Glu Ala Ile Asp 
    50                  55                  60                  

Phe Tyr His Arg Tyr Lys Glu Asp Ile Ala Leu Phe Ala Glu Met Gly 
65                  70                  75                  80  

Phe Lys Cys Phe Arg Thr Ser Ile Ala Trp Thr Arg Ile Phe Pro Lys 
                85                  90                  95      

Gly Asp Glu Leu Glu Pro Asn Glu Glu Gly Leu Gln Phe Tyr Asp Asn 
            100                 105                 110         

Leu Phe Asp Glu Cys Leu Lys Asn Gly Ile Glu Pro Val Ile Thr Leu 
        115                 120                 125             

Ser His Phe Glu Met Pro Tyr His Leu Val Thr Glu Tyr Gly Gly Trp 
    130                 135                 140                 

Lys Asn Arg Lys Leu Ile Asp Phe Phe Ala Arg Phe Ala Glu Val Val 
145                 150                 155                 160 

Phe Lys Arg Tyr Lys Asp Lys Val Lys Tyr Trp Met Thr Phe Asn Glu 
                165                 170                 175     

Ile Asn Asn Gln Ala Asn Tyr Gln Glu Asp Phe Ala Pro Phe Thr Asn 
            180                 185                 190         

Ser Gly Ile Val Tyr Glu Glu Gly Asp Asn Arg Glu Ala Ile Met Tyr 
        195                 200                 205             

Gln Ala Ala His Tyr Glu Leu Val Ala Ser Ala Arg Ala Val Lys Ile 
    210                 215                 220                 

Gly His Glu Ile Asn Pro Asp Phe Gln Ile Gly Cys Met Ile Ala Met 
225                 230                 235                 240 

Cys Pro Ile Tyr Pro Val Thr Cys Asn Pro Lys Asp Ile Leu Met Ala 
                245                 250                 255     

Met Lys Ala Met Gln Lys Arg Tyr Tyr Phe Ala Asp Val His Val Leu 
            260                 265                 270         

Gly Lys Tyr Pro Glu His Ile Phe Lys Tyr Trp Glu Arg Lys Gly Ile 
        275                 280                 285             

Ser Val Asp Phe Thr Ala Gln Asp Lys Glu Asp Leu Leu Gly Gly Thr 
    290                 295                 300                 

Val Asp Tyr Ile Gly Phe Ser Tyr Tyr Met Ser Phe Ala Ile Asp Ser 
305                 310                 315                 320 

His Arg Glu Asn Asn Pro Tyr Phe Asp Tyr Leu Glu Thr Glu Asp Leu 
                325                 330                 335     

Val Lys Asn Asn Tyr Val Lys Ala Ser Glu Trp Glu Trp Gln Ile Asp 
            340                 345                 350         


Pro Glu Gly Leu Arg Tyr Ala Leu Asn Trp Phe Thr Asp His Tyr His 
        355                 360                 365             

Leu Pro Leu Phe Ile Val Glu Asn Gly Phe Gly Ala Ile Asp Gln Val 
    370                 375                 380                 

Ala Ala Asp Gly Met Val His Asp Asp Tyr Arg Ile Glu Tyr Leu Gly 
385                 390                 395                 400 

Ala His Ile Arg Glu Met Lys Lys Ala Val Val Glu Asp Gly Val Asp 
                405                 410                 415     

Leu Met Gly Tyr Thr Pro Trp Gly Cys Ile Asp Leu Val Ser Ala Gly 
            420                 425                 430         

Thr Gly Glu Met Arg Lys Arg Tyr Gly Phe Ile Tyr Val Asp Lys Asp 
        435                 440                 445             

Asp Asn Gly Lys Gly Ser Tyr Asn Arg Ser Pro Lys Lys Ser Phe Gly 
    450                 455                 460                 

Trp Tyr Lys Glu Val Ile Ser Ser Asn Gly Glu Ser Val Glu 
465                 470                 475             

<210>   439
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   439
atgattggaa gtattgcagc aattttaaca acatttgcat ttttaccaca agtttttcgt   60
gtagttaaga caaaggacac aggatctatt gctctaggta tgtatgttat gcaagttatt   120
ggtattgcat tgtggcttgc tcatggtatt cgtataggag acttgccttt gattttagca   180
aatagtgttt catttctact ctcaggaata attttatttt ataaattgaa gtataaa      237

<210>   440
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902321 (1.E-39)

<400>   440
Met Ile Gly Ser Ile Ala Ala Ile Leu Thr Thr Phe Ala Phe Leu Pro 
1               5                   10                  15      

Gln Val Phe Arg Val Val Lys Thr Lys Asp Thr Gly Ser Ile Ala Leu 
            20                  25                  30          

Gly Met Tyr Val Met Gln Val Ile Gly Ile Ala Leu Trp Leu Ala His 
        35                  40                  45              

Gly Ile Arg Ile Gly Asp Leu Pro Leu Ile Leu Ala Asn Ser Val Ser 
    50                  55                  60                  

Phe Leu Leu Ser Gly Ile Ile Leu Phe Tyr Lys Leu Lys Tyr Lys 
65                  70                  75                  

<210>   441
<211>   312
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   441
atggcaaaag ctttaattat ttgtgcagca ggaatgtctt catcacttat ggcacagaaa   60
acaacagagt ttctaaaagg aaaagggaaa gatattgtag ttgatgctat tagtgctact   120
gaaggaggga aagctatcgc agcagcagct tttgatttgt atcttgtcag tcctcaaaca   180
aaaatgtact ttaagcaatt tgaagaggct ggttctaaag caggaaaacc agttgtacaa   240
atacctcctc aagcctatat tcctattcca atgggaattg aaaaaatggc taatttgatt   300
cttgagaata tt                                                       312

<210>   442
<211>   104
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIB component
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902322 (3.E-54)

<400>   442
Met Ala Lys Ala Leu Ile Ile Cys Ala Ala Gly Met Ser Ser Ser Leu 
1               5                   10                  15      

Met Ala Gln Lys Thr Thr Glu Phe Leu Lys Gly Lys Gly Lys Asp Ile 
            20                  25                  30          

Val Val Asp Ala Ile Ser Ala Thr Glu Gly Gly Lys Ala Ile Ala Ala 
        35                  40                  45              

Ala Ala Phe Asp Leu Tyr Leu Val Ser Pro Gln Thr Lys Met Tyr Phe 
    50                  55                  60                  

Lys Gln Phe Glu Glu Ala Gly Ser Lys Ala Gly Lys Pro Val Val Gln 
65                  70                  75                  80  

Ile Pro Pro Gln Ala Tyr Ile Pro Ile Pro Met Gly Ile Glu Lys Met 
                85                  90                  95      

Ala Asn Leu Ile Leu Glu Asn Ile 
            100                 

<210>   443
<211>   1479
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   443
atgaatgtgt taaacattaa agagaaagat atccttcaat ttttaataaa aaataaggaa   60
cgttttgtta caagcaaaga actggcagaa tatttatcct gttcagatag aactgtccgt   120
aatgtactga aattaattga gaagacaatg attattcaag gagtccggtt gatttcaaaa   180
caaggtcaag ggtatcaaat attttttgag aatcaaggcg cttaccagga gtttagacaa   240
acttatgaac tggaagaaga ctatacgaaa actgcggttt caaaaggtga tgatcgttta   300
gtatttatct taaataaatt attatttgag caagttccag ttctttttga tgatttagct   360
gatgaacttt acgttagtcg ttcaacatta tctcatgatt tcagaaagat acgagtgatg   420
ttatcagagt ataatttgtc cattgagagt agggcgaata aaggagttta tgtctcaggc   480
gaggaacgtg ataaacgacg ttttatcata aattatttcc tagagaatca attttttaaa   540
acaatacatt gctatgtaaa atttaacttt tttgatcaaa ctgttccatt agaagaattt   600
gctagaattg ttttggatga atgccaagag gccaacctaa aactatctga ttttgtacta   660
cagaatttag tagttcacat agcattgtct gtgattcgtt taaaatccgg atttgaaata   720
aaaaatatag actgtcagat gactgatgat gcaatagaga gaaaggttgc ccaaagaatt   780
ctttctaaag taagagaagt aacaaatcag gaatttccag ttcaggaaat agactacatt   840
actttgcatt tgttagctaa gagtcaacaa tgtcaaaaaa atcagaagaa tatttctgaa   900
gaagttttaa aaaaatcttt atttaaaaca tttcagaatt taggattaga tgatatgtat   960
aacttttctt cagatttcca actaattgaa ggattgataa ctcatctaat gacactacaa   1020
gtacgtttag aaagccggat taccttaaat aaccctttgg tagatgaaat taaacagaat   1080
tatagtgata tattctttat gactagagaa attcttgcaa atatggacaa gttcttggag   1140
tggacaatat cagatgatga agtagcatat gtaagtcttc actttttagc tgctatggaa   1200
cgtagcaaag agagtactaa gtttaatatt cttgctattt gtgcaacagg atttggtgca   1260
gcccaaatgt taagaaatcg tttggaaacg gagtttggga agcgagtaga agttgttgat   1320
gtaataggct actatgaatt gaatcaagaa aaacttaaag gaatagattt tatagtgtca   1380
gctattgatt tatcaaatct atattttcaa atcccagttt ttaaagttag tgtgtttctt   1440
aagagtgatg agatggaaat gattagaaaa gctatggat                          1479

<210>   444
<211>   493
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: membrane
<223>   Feature of note: similar to Mga
<223>   Similar to strain R6 sequence 15902323 (0.E+01)

<400>   444
Met Asn Val Leu Asn Ile Lys Glu Lys Asp Ile Leu Gln Phe Leu Ile 
1               5                   10                  15      

Lys Asn Lys Glu Arg Phe Val Thr Ser Lys Glu Leu Ala Glu Tyr Leu 
            20                  25                  30          

Ser Cys Ser Asp Arg Thr Val Arg Asn Val Leu Lys Leu Ile Glu Lys 
        35                  40                  45              

Thr Met Ile Ile Gln Gly Val Arg Leu Ile Ser Lys Gln Gly Gln Gly 
    50                  55                  60                  

Tyr Gln Ile Phe Phe Glu Asn Gln Gly Ala Tyr Gln Glu Phe Arg Gln 
65                  70                  75                  80  

Thr Tyr Glu Leu Glu Glu Asp Tyr Thr Lys Thr Ala Val Ser Lys Gly 
                85                  90                  95      

Asp Asp Arg Leu Val Phe Ile Leu Asn Lys Leu Leu Phe Glu Gln Val 
            100                 105                 110         

Pro Val Leu Phe Asp Asp Leu Ala Asp Glu Leu Tyr Val Ser Arg Ser 
        115                 120                 125             

Thr Leu Ser His Asp Phe Arg Lys Ile Arg Val Met Leu Ser Glu Tyr 
    130                 135                 140                 

Asn Leu Ser Ile Glu Ser Arg Ala Asn Lys Gly Val Tyr Val Ser Gly 
145                 150                 155                 160 

Glu Glu Arg Asp Lys Arg Arg Phe Ile Ile Asn Tyr Phe Leu Glu Asn 
                165                 170                 175     

Gln Phe Phe Lys Thr Ile His Cys Tyr Val Lys Phe Asn Phe Phe Asp 
            180                 185                 190         

Gln Thr Val Pro Leu Glu Glu Phe Ala Arg Ile Val Leu Asp Glu Cys 
        195                 200                 205             

Gln Glu Ala Asn Leu Lys Leu Ser Asp Phe Val Leu Gln Asn Leu Val 
    210                 215                 220                 

Val His Ile Ala Leu Ser Val Ile Arg Leu Lys Ser Gly Phe Glu Ile 
225                 230                 235                 240 

Lys Asn Ile Asp Cys Gln Met Thr Asp Asp Ala Ile Glu Arg Lys Val 
                245                 250                 255     

Ala Gln Arg Ile Leu Ser Lys Val Arg Glu Val Thr Asn Gln Glu Phe 
            260                 265                 270         

Pro Val Gln Glu Ile Asp Tyr Ile Thr Leu His Leu Leu Ala Lys Ser 
        275                 280                 285             

Gln Gln Cys Gln Lys Asn Gln Lys Asn Ile Ser Glu Glu Val Leu Lys 
    290                 295                 300                 

Lys Ser Leu Phe Lys Thr Phe Gln Asn Leu Gly Leu Asp Asp Met Tyr 
305                 310                 315                 320 

Asn Phe Ser Ser Asp Phe Gln Leu Ile Glu Gly Leu Ile Thr His Leu 
                325                 330                 335     

Met Thr Leu Gln Val Arg Leu Glu Ser Arg Ile Thr Leu Asn Asn Pro 
            340                 345                 350         

Leu Val Asp Glu Ile Lys Gln Asn Tyr Ser Asp Ile Phe Phe Met Thr 
        355                 360                 365             

Arg Glu Ile Leu Ala Asn Met Asp Lys Phe Leu Glu Trp Thr Ile Ser 
    370                 375                 380                 

Asp Asp Glu Val Ala Tyr Val Ser Leu His Phe Leu Ala Ala Met Glu 
385                 390                 395                 400 

Arg Ser Lys Glu Ser Thr Lys Phe Asn Ile Leu Ala Ile Cys Ala Thr 
                405                 410                 415     

Gly Phe Gly Ala Ala Gln Met Leu Arg Asn Arg Leu Glu Thr Glu Phe 
            420                 425                 430         

Gly Lys Arg Val Glu Val Val Asp Val Ile Gly Tyr Tyr Glu Leu Asn 
        435                 440                 445             

Gln Glu Lys Leu Lys Gly Ile Asp Phe Ile Val Ser Ala Ile Asp Leu 
    450                 455                 460                 

Ser Asn Leu Tyr Phe Gln Ile Pro Val Phe Lys Val Ser Val Phe Leu 
465                 470                 475                 480 

Lys Ser Asp Glu Met Glu Met Ile Arg Lys Ala Met Asp 
                485                 490             

<210>   445
<211>   495
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   445
atgcaagttt ctagttatgt acaatcatca aagattaaca aatttgaaaa caacggcttt   60
agacagtatt ttagtaaaga aaacttttta atatgtactg aatcagacaa ggtaaattta   120
cttgaaaaga tggttgagag tttatctgtt ggtgaatcaa atgagtttga acaatcttta   180
ctttatggaa ttaaacagcg cgaagaatta agttcagttg ttttttctga aaaaattgca   240
gttccgcatc ctattcagcc ctttggtaca gagggaaagg tttcggttgc aatttgtaaa   300
gattcgttac tctgggataa tcaaagttca catgtccagc tagtatttct tctatctcca   360
tcaatatatg ggaacgaagg tttggcaact gtgactaaaa agatagtctc tctgacagag   420
aatgatgaat tgcaaaatca gctaatatct tgcaataact ttgaagattt tattaacata   480
tttgagaaga taaaa                                                    495

<210>   446
<211>   165
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIA component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902323 (1.E-86)

<400>   446
Met Gln Val Ser Ser Tyr Val Gln Ser Ser Lys Ile Asn Lys Phe Glu 
1               5                   10                  15      

Asn Asn Gly Phe Arg Gln Tyr Phe Ser Lys Glu Asn Phe Leu Ile Cys 
            20                  25                  30          

Thr Glu Ser Asp Lys Val Asn Leu Leu Glu Lys Met Val Glu Ser Leu 
        35                  40                  45              

Ser Val Gly Glu Ser Asn Glu Phe Glu Gln Ser Leu Leu Tyr Gly Ile 
    50                  55                  60                  

Lys Gln Arg Glu Glu Leu Ser Ser Val Val Phe Ser Glu Lys Ile Ala 
65                  70                  75                  80  

Val Pro His Pro Ile Gln Pro Phe Gly Thr Glu Gly Lys Val Ser Val 
                85                  90                  95      

Ala Ile Cys Lys Asp Ser Leu Leu Trp Asp Asn Gln Ser Ser His Val 
            100                 105                 110         

Gln Leu Val Phe Leu Leu Ser Pro Ser Ile Tyr Gly Asn Glu Gly Leu 
        115                 120                 125             

Ala Thr Val Thr Lys Lys Ile Val Ser Leu Thr Glu Asn Asp Glu Leu 
    130                 135                 140                 

Gln Asn Gln Leu Ile Ser Cys Asn Asn Phe Glu Asp Phe Ile Asn Ile 
145                 150                 155                 160 

Phe Glu Lys Ile Lys 
                165 

<210>   447
<211>   312
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   447
atgaatcaag aggaactgca ggttgcagca tttgaaatta tcctgcattc gggaaatgca   60
aggtcagaaa tacatgaagc atttgcaaaa atgagagaag gtagttttga tgatgcagaa   120
agtaaattaa atcaatcaaa tgagataatt cttgaagcgc atcatgcaca aaccaaactc   180
ttgcaagaat acgcaagtgg agtggaaatt aaaattgaaa ttatcatggt acatgctcaa   240
gatcatttaa tgaccactat gacattatta gaagtagcaa aggaaatgtt agctctttat   300
aagaaagtta ac                                                       312

<210>   448
<211>   104
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIA component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902324 (4.E-54)

<400>   448
Met Asn Gln Glu Glu Leu Gln Val Ala Ala Phe Glu Ile Ile Leu His 
1               5                   10                  15      

Ser Gly Asn Ala Arg Ser Glu Ile His Glu Ala Phe Ala Lys Met Arg 
            20                  25                  30          

Glu Gly Ser Phe Asp Asp Ala Glu Ser Lys Leu Asn Gln Ser Asn Glu 
        35                  40                  45              

Ile Ile Leu Glu Ala His His Ala Gln Thr Lys Leu Leu Gln Glu Tyr 
    50                  55                  60                  

Ala Ser Gly Val Glu Ile Lys Ile Glu Ile Ile Met Val His Ala Gln 
65                  70                  75                  80  

Asp His Leu Met Thr Thr Met Thr Leu Leu Glu Val Ala Lys Glu Met 
                85                  90                  95      

Leu Ala Leu Tyr Lys Lys Val Asn 
            100                 

<210>   449
<211>   504
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   449
atggataaaa aagaacgaca aaagattgaa caacaacgtc gagagatggc tctaactaat   60
acttttttca atcgatatct tcttctacgt tattcaatag cactcttctt ttttgggaat   120
atttattggc ttttgagtca gtttattagt ccctcgccta ttattatttt ccccattatg   180
ctcatagtat tttctatttt agcaactgtt gaacaattta aactttatgg aaataggaaa   240
gaaaagttgg gaataacact aatgtttgtt agaatacaaa tgcttatttc aataggatta   300
cttgttttaa cttggacaag ttggtttaag aatctttttc cgatttttga aaataaccaa   360
gtagcacgtt tatttgtttt tgtagttctt ctattaggtt tagttctgag tttgttagac   420
attagaagaa ttaaaaaaat ttataaacga acagataagg cttatcaaca atttgtccaa   480
ttggaaaaga actcacttag ttta                                          504

<210>   450
<211>   168
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902325 (2.E-88)

<400>   450
Met Asp Lys Lys Glu Arg Gln Lys Ile Glu Gln Gln Arg Arg Glu Met 
1               5                   10                  15      

Ala Leu Thr Asn Thr Phe Phe Asn Arg Tyr Leu Leu Leu Arg Tyr Ser 
            20                  25                  30          

Ile Ala Leu Phe Phe Phe Gly Asn Ile Tyr Trp Leu Leu Ser Gln Phe 
        35                  40                  45              

Ile Ser Pro Ser Pro Ile Ile Ile Phe Pro Ile Met Leu Ile Val Phe 
    50                  55                  60                  

Ser Ile Leu Ala Thr Val Glu Gln Phe Lys Leu Tyr Gly Asn Arg Lys 
65                  70                  75                  80  

Glu Lys Leu Gly Ile Thr Leu Met Phe Val Arg Ile Gln Met Leu Ile 
                85                  90                  95      

Ser Ile Gly Leu Leu Val Leu Thr Trp Thr Ser Trp Phe Lys Asn Leu 
            100                 105                 110         

Phe Pro Ile Phe Glu Asn Asn Gln Val Ala Arg Leu Phe Val Phe Val 
        115                 120                 125             

Val Leu Leu Leu Gly Leu Val Leu Ser Leu Leu Asp Ile Arg Arg Ile 
    130                 135                 140                 

Lys Lys Ile Tyr Lys Arg Thr Asp Lys Ala Tyr Gln Gln Phe Val Gln 
145                 150                 155                 160 

Leu Glu Lys Asn Ser Leu Ser Leu 
                165             

<210>   451
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   451
atggatcaac aaaacgggtt gtttggtttt cttgaaaacc atgttatggg accaatgggc   60
aaacttgctc agtttaaagt agtacgtgct atcacggctg caggtatggc tgctgtacca   120
tttactattg taggatcaat gtttttggta ttcagtattt tgccacaagc tttctcattt   180
tggccaattg tggcagatat tttctctgct tcatttgata aattcacatc actttacatg   240
gttgcaaact atgcgactat gggttctcta tctctttatt tcgttctatc acttgcatat   300
gaattgacaa aaatttatgc agaggaagaa gaactcaata tgaatcctct taatggtgcc   360
ttgcttgcct tgatggcttt tgtcatgaca gtaccgcaaa tcatttttga tggtggaatg   420
atgaagactg tgacaagtct aaaagaaggt gcagtaattg cagatggatg ggcaatggga   480
aatgtagtcg cacgttttgg gacaacaggg atttttaccg caatcattat ggcaattgtg   540
actgttctta tttatcgtat gtgtgttaaa cataattggg ttattaaaat gcctgaagct   600
gttccagaag gagtttctcg tggatttacc gctttggttc cgggatttgt tgttgcattt   660
gttgttatct ttatcaacgg tcttcttgta gcaatgggaa cagatatttt taaagtcatt   720
gcaattccat ttggttttgt atccaatctg actaattcgt ggattggttt aatgattatt   780
tatctattga ctcaactact ttggattgta ggtatccacg gtgcgaacat tgtttttgca   840
tttgttagtc caattgctct tgctaacatg gctgaaaatg ctgctggcgg gcacttcgct   900
gttgcaggtg aattttctaa tatgtttgta attgcaggtg gttctggtgc aactttagga   960
ctatgtttat atattgcttt tgcctctaaa tctgaacagc ttaaagcaat aggacgagca   1020
tctgtagttc cagccttatt taatattaat gaaccattaa tttttggatt acctattatc   1080
tataatccag ccttggctat accatttatt ttagcaccaa tggttactgc tactatttat   1140
tacgtagcga attctctaaa ctttattaag ccaattatcg cacaggttcc atggccaact   1200
ccagtaggga ttggagcttt cttagggaca gcagatcttc gagctgtatt agttgctcta   1260
gtatgtgcat ttgcagcatt cctagtctat cttccattca tccgtgtata tgatcaaaaa   1320
ttggtgaaag aagagcaagg tatc                                          1344

<210>   452
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIC component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902326 (0.E+01)

<400>   452
Met Asp Gln Gln Asn Gly Leu Phe Gly Phe Leu Glu Asn His Val Met 
1               5                   10                  15      

Gly Pro Met Gly Lys Leu Ala Gln Phe Lys Val Val Arg Ala Ile Thr 
            20                  25                  30          

Ala Ala Gly Met Ala Ala Val Pro Phe Thr Ile Val Gly Ser Met Phe 
        35                  40                  45              

Leu Val Phe Ser Ile Leu Pro Gln Ala Phe Ser Phe Trp Pro Ile Val 
    50                  55                  60                  

Ala Asp Ile Phe Ser Ala Ser Phe Asp Lys Phe Thr Ser Leu Tyr Met 
65                  70                  75                  80  

Val Ala Asn Tyr Ala Thr Met Gly Ser Leu Ser Leu Tyr Phe Val Leu 

                85                  90                  95      

Ser Leu Ala Tyr Glu Leu Thr Lys Ile Tyr Ala Glu Glu Glu Glu Leu 
            100                 105                 110         

Asn Met Asn Pro Leu Asn Gly Ala Leu Leu Ala Leu Met Ala Phe Val 
        115                 120                 125             

Met Thr Val Pro Gln Ile Ile Phe Asp Gly Gly Met Met Lys Thr Val 
    130                 135                 140                 

Thr Ser Leu Lys Glu Gly Ala Val Ile Ala Asp Gly Trp Ala Met Gly 
145                 150                 155                 160 

Asn Val Val Ala Arg Phe Gly Thr Thr Gly Ile Phe Thr Ala Ile Ile 
                165                 170                 175     

Met Ala Ile Val Thr Val Leu Ile Tyr Arg Met Cys Val Lys His Asn 
            180                 185                 190         

Trp Val Ile Lys Met Pro Glu Ala Val Pro Glu Gly Val Ser Arg Gly 
        195                 200                 205             

Phe Thr Ala Leu Val Pro Gly Phe Val Val Ala Phe Val Val Ile Phe 
    210                 215                 220                 

Ile Asn Gly Leu Leu Val Ala Met Gly Thr Asp Ile Phe Lys Val Ile 
225                 230                 235                 240 

Ala Ile Pro Phe Gly Phe Val Ser Asn Leu Thr Asn Ser Trp Ile Gly 
                245                 250                 255     

Leu Met Ile Ile Tyr Leu Leu Thr Gln Leu Leu Trp Ile Val Gly Ile 
            260                 265                 270         

His Gly Ala Asn Ile Val Phe Ala Phe Val Ser Pro Ile Ala Leu Ala 
        275                 280                 285             

Asn Met Ala Glu Asn Ala Ala Gly Gly His Phe Ala Val Ala Gly Glu 
    290                 295                 300                 

Phe Ser Asn Met Phe Val Ile Ala Gly Gly Ser Gly Ala Thr Leu Gly 
305                 310                 315                 320 

Leu Cys Leu Tyr Ile Ala Phe Ala Ser Lys Ser Glu Gln Leu Lys Ala 
                325                 330                 335     

Ile Gly Arg Ala Ser Val Val Pro Ala Leu Phe Asn Ile Asn Glu Pro 
            340                 345                 350         

Leu Ile Phe Gly Leu Pro Ile Ile Tyr Asn Pro Ala Leu Ala Ile Pro 
        355                 360                 365             

Phe Ile Leu Ala Pro Met Val Thr Ala Thr Ile Tyr Tyr Val Ala Asn 
    370                 375                 380                 

Ser Leu Asn Phe Ile Lys Pro Ile Ile Ala Gln Val Pro Trp Pro Thr 
385                 390                 395                 400 

Pro Val Gly Ile Gly Ala Phe Leu Gly Thr Ala Asp Leu Arg Ala Val 
                405                 410                 415     

Leu Val Ala Leu Val Cys Ala Phe Ala Ala Phe Leu Val Tyr Leu Pro 
            420                 425                 430         

Phe Ile Arg Val Tyr Asp Gln Lys Leu Val Lys Glu Glu Gln Gly Ile 
        435                 440                 445             


<210>   453
<211>   174
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   453
atgtccttag atatagataa agaaaagatg acaatcatgg gaatagcttt tgaaaaccga   60
tccgttttta agagtgtttg gtatgcttta agtacaaata tgattgaagg atggcgacct   120
acggttagtg atgttgaaaa attacgagat gaagctcttg ctctggggat gact         174

<210>   454
<211>   58
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902327 (3.E-29)

<400>   454
Met Ser Leu Asp Ile Asp Lys Glu Lys Met Thr Ile Met Gly Ile Ala 
1               5                   10                  15      


Phe Glu Asn Arg Ser Val Phe Lys Ser Val Trp Tyr Ala Leu Ser Thr 
            20                  25                  30          

Asn Met Ile Glu Gly Trp Arg Pro Thr Val Ser Asp Val Glu Lys Leu 
        35                  40                  45              

Arg Asp Glu Ala Leu Ala Leu Gly Met Thr 
    50                  55              

<210>   455
<211>   2211
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   455
ttgaaaattt ttaagggaga gttttatcga atctctgtat taacagacaa gctagtaagg   60
ttagaatact ctcaaactgg aagttttgag gatagaacga cacaacttat ctataataga   120
gattttggcc aaatttcgtt agattatatc gagacatcaa acgtactaga tattatgacg   180
gactattttc atctgcactt taataaagga gaatttaacg ccgaaaattt atttatagaa   240
ttaaaaggaa attttgccgt atatggtagt cgctggtatt ttggtgaatc tattgaaacg   300
ttaaaaggaa cagctcggac tctggataag gcagatggag caatctcgtt agaagatgga   360
attattagcc gaaatggtat agccttattg gatgattctc aaggatttat ttgggatgaa   420
caatctggtt atattgagag agaaaatcaa attgacctgt atttctttgc ctatgggcat   480
gattatagag gagcaatcag agatttttac catttgactg gttcaacacc cttgttgcca   540
agatatgctt taggcaattg gtggagtaga tattggcctt atacgtcgga tgaatacttg   600
gatttaatag acagatttga aacagagaaa attccattat ctatcggtgt gttagatatg   660
gattggcata taactgacat tccagctcgc tttggaagtg gctggacagg atatagttgg   720
aatagaaact taataccaaa tccagaacag ttattgcaac aacttcatga tagaaagcta   780
aaactctcct taaatgtcca tcctgctgat gggatacggg cttatgaaga agcttatcct   840
caaatcgcaa aacggttggg gttaaatgta gaactagaag aacctgctat ttttgatttt   900
tttaatccct cttttaggga agcctacttt aaagatgttc attatgaact agaaaagcag   960
ggagtagatt tttggtggat tgactggcaa caagggacac aaggtatgct agatccactt   1020
tggcttttaa accattatca ctatcaggat agttgtaaaa atgcagaagg tggtttgatt   1080
ttatcaagat atgcaggtcc tggtagtcac cgctaccctg ttggtttttc aggggatact   1140
attattagtt ggaattcctt aagatttcaa ccctatttta cagcgacagc atctaatatc   1200
ggttatagtt ggtggagtca tgatatcggt ggacatatgt tgggggatta tgacgaagag   1260
ctacaaacta gatggctaca gtttggtgtt tttagtccga ttactcgatt acatagttct   1320
agaagtcctt ttaatagtaa agaaccttgg tttttttcag aaacaacatc taagattatg   1380
aagaaatacc ttcgtttgag acatcagatg attccctatc tatataccat gaatgtacag   1440
acacatgagg aaggtgcccc attaatcagt ccaatctatt atttctatcc agagaatgat   1500
gagagctata atgttccaaa ccaatacttt tttggaacag aactgatggt ggctcccatt   1560
gtagaaaaga tggatttgac attccaatct gcaaaagtag atgtatggtt ccctgaaggt   1620
gaatggtatg acttcttttc agagaaaaaa tacacaggtg gtgtgaagtt aagtgtttat   1680
agggacatct cgactacgcc tgtgtttgca aaaagtggtg caatcattcc cttggttggt   1740
tctgagatag gtatgggtgt tgatttacct gaagttgtag attggtatgt attcccagga   1800
aaacaacatt cttttgaaat gcttgaagat caaaatggtc aaagatataa aacaagatta   1860
tcaatcgatt gggaaatggg aatggtagag ttagcattac aaggagattc tagtatcgtt   1920
ccaagcaata gaaaacatag aattcatttt aaaggaacga atgtgtctat aattgaattg   1980
ccaaataaga atgatacagc taaatttgaa tggaaagata ataaaaggac atctttaaat   2040
gacgaagttt ttagactact aaagacagct tctcttccat atgaattaaa agatagattg   2100
ttaaatcaat tcatcaatgc gaaaaactct catgacttaa tgaatatctt gcatcatcag   2160
gataaggaat tgagagggcg tttgttggaa atgatattta ctagccaaaa c            2211

<210>   456
<211>   737
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl hydrolase, family 31
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902328 (0.E+01)

<400>   456
Met Lys Ile Phe Lys Gly Glu Phe Tyr Arg Ile Ser Val Leu Thr Asp 
1               5                   10                  15      

Lys Leu Val Arg Leu Glu Tyr Ser Gln Thr Gly Ser Phe Glu Asp Arg 
            20                  25                  30          

Thr Thr Gln Leu Ile Tyr Asn Arg Asp Phe Gly Gln Ile Ser Leu Asp 
        35                  40                  45              

Tyr Ile Glu Thr Ser Asn Val Leu Asp Ile Met Thr Asp Tyr Phe His 
    50                  55                  60                  


Leu His Phe Asn Lys Gly Glu Phe Asn Ala Glu Asn Leu Phe Ile Glu 
65                  70                  75                  80  

Leu Lys Gly Asn Phe Ala Val Tyr Gly Ser Arg Trp Tyr Phe Gly Glu 
                85                  90                  95      

Ser Ile Glu Thr Leu Lys Gly Thr Ala Arg Thr Leu Asp Lys Ala Asp 
            100                 105                 110         

Gly Ala Ile Ser Leu Glu Asp Gly Ile Ile Ser Arg Asn Gly Ile Ala 
        115                 120                 125             

Leu Leu Asp Asp Ser Gln Gly Phe Ile Trp Asp Glu Gln Ser Gly Tyr 
    130                 135                 140                 

Ile Glu Arg Glu Asn Gln Ile Asp Leu Tyr Phe Phe Ala Tyr Gly His 
145                 150                 155                 160 

Asp Tyr Arg Gly Ala Ile Arg Asp Phe Tyr His Leu Thr Gly Ser Thr 
                165                 170                 175     

Pro Leu Leu Pro Arg Tyr Ala Leu Gly Asn Trp Trp Ser Arg Tyr Trp 
            180                 185                 190         

Pro Tyr Thr Ser Asp Glu Tyr Leu Asp Leu Ile Asp Arg Phe Glu Thr 
        195                 200                 205             

Glu Lys Ile Pro Leu Ser Ile Gly Val Leu Asp Met Asp Trp His Ile 
    210                 215                 220                 

Thr Asp Ile Pro Ala Arg Phe Gly Ser Gly Trp Thr Gly Tyr Ser Trp 
225                 230                 235                 240 

Asn Arg Asn Leu Ile Pro Asn Pro Glu Gln Leu Leu Gln Gln Leu His 
                245                 250                 255     

Asp Arg Lys Leu Lys Leu Ser Leu Asn Val His Pro Ala Asp Gly Ile 
            260                 265                 270         

Arg Ala Tyr Glu Glu Ala Tyr Pro Gln Ile Ala Lys Arg Leu Gly Leu 
        275                 280                 285             

Asn Val Glu Leu Glu Glu Pro Ala Ile Phe Asp Phe Phe Asn Pro Ser 
    290                 295                 300                 

Phe Arg Glu Ala Tyr Phe Lys Asp Val His Tyr Glu Leu Glu Lys Gln 
305                 310                 315                 320 

Gly Val Asp Phe Trp Trp Ile Asp Trp Gln Gln Gly Thr Gln Gly Met 
                325                 330                 335     

Leu Asp Pro Leu Trp Leu Leu Asn His Tyr His Tyr Gln Asp Ser Cys 
            340                 345                 350         

Lys Asn Ala Glu Gly Gly Leu Ile Leu Ser Arg Tyr Ala Gly Pro Gly 
        355                 360                 365             

Ser His Arg Tyr Pro Val Gly Phe Ser Gly Asp Thr Ile Ile Ser Trp 
    370                 375                 380                 

Asn Ser Leu Arg Phe Gln Pro Tyr Phe Thr Ala Thr Ala Ser Asn Ile 
385                 390                 395                 400 

Gly Tyr Ser Trp Trp Ser His Asp Ile Gly Gly His Met Leu Gly Asp 
                405                 410                 415     

Tyr Asp Glu Glu Leu Gln Thr Arg Trp Leu Gln Phe Gly Val Phe Ser 
            420                 425                 430         

Pro Ile Thr Arg Leu His Ser Ser Arg Ser Pro Phe Asn Ser Lys Glu 
        435                 440                 445             

Pro Trp Phe Phe Ser Glu Thr Thr Ser Lys Ile Met Lys Lys Tyr Leu 
    450                 455                 460                 

Arg Leu Arg His Gln Met Ile Pro Tyr Leu Tyr Thr Met Asn Val Gln 
465                 470                 475                 480 

Thr His Glu Glu Gly Ala Pro Leu Ile Ser Pro Ile Tyr Tyr Phe Tyr 
                485                 490                 495     

Pro Glu Asn Asp Glu Ser Tyr Asn Val Pro Asn Gln Tyr Phe Phe Gly 
            500                 505                 510         

Thr Glu Leu Met Val Ala Pro Ile Val Glu Lys Met Asp Leu Thr Phe 
        515                 520                 525             

Gln Ser Ala Lys Val Asp Val Trp Phe Pro Glu Gly Glu Trp Tyr Asp 
    530                 535                 540                 

Phe Phe Ser Glu Lys Lys Tyr Thr Gly Gly Val Lys Leu Ser Val Tyr 
545                 550                 555                 560 

Arg Asp Ile Ser Thr Thr Pro Val Phe Ala Lys Ser Gly Ala Ile Ile 
                565                 570                 575     

Pro Leu Val Gly Ser Glu Ile Gly Met Gly Val Asp Leu Pro Glu Val 
            580                 585                 590         

Val Asp Trp Tyr Val Phe Pro Gly Lys Gln His Ser Phe Glu Met Leu 
        595                 600                 605             

Glu Asp Gln Asn Gly Gln Arg Tyr Lys Thr Arg Leu Ser Ile Asp Trp 
    610                 615                 620                 

Glu Met Gly Met Val Glu Leu Ala Leu Gln Gly Asp Ser Ser Ile Val 
625                 630                 635                 640 

Pro Ser Asn Arg Lys His Arg Ile His Phe Lys Gly Thr Asn Val Ser 
                645                 650                 655     

Ile Ile Glu Leu Pro Asn Lys Asn Asp Thr Ala Lys Phe Glu Trp Lys 
            660                 665                 670         

Asp Asn Lys Arg Thr Ser Leu Asn Asp Glu Val Phe Arg Leu Leu Lys 
        675                 680                 685             

Thr Ala Ser Leu Pro Tyr Glu Leu Lys Asp Arg Leu Leu Asn Gln Phe 
    690                 695                 700                 

Ile Asn Ala Lys Asn Ser His Asp Leu Met Asn Ile Leu His His Gln 
705                 710                 715                 720 

Asp Lys Glu Leu Arg Gly Arg Leu Leu Glu Met Ile Phe Thr Ser Gln 
                725                 730                 735     

Asn 
    

<210>   457
<211>   474
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   457
atgacttcac tttatgattt ttccgttttg aaccaaaaca accaagcaac tcccttggat   60
agctatcgtg gcaaagttct cttgattgtc aacactgcta ctggatgtgg tttaacgccc   120
cagtaccagg gacttcaaga actctatgaa cgctatcaag atcagggctt cgaaatattg   180
gatttccctt gcaatcagtt tatgggacaa gcacccggca gcgcagagga aatcaacgcc   240
ttctgtagcc tacattttca aaccaccttc ccacgttttg ccaagattaa ggtcaacggt   300
aaggaagcag accctctcta tgtctggtta caagaccaga aatccggccc actaggaaaa   360
cgagtcgaat ggaatttcgc taagtttctc atcggtcgag atgggcaagt ctttgaacgc   420
ttttcttcaa aaacagaccc aaaacaaatt gaagaggcga tacaaactct acta         474

<210>   458
<211>   158
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutathione peroxidase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902329 (7.E-90)

<400>   458
Met Thr Ser Leu Tyr Asp Phe Ser Val Leu Asn Gln Asn Asn Gln Ala 
1               5                   10                  15      

Thr Pro Leu Asp Ser Tyr Arg Gly Lys Val Leu Leu Ile Val Asn Thr 
            20                  25                  30          

Ala Thr Gly Cys Gly Leu Thr Pro Gln Tyr Gln Gly Leu Gln Glu Leu 
        35                  40                  45              

Tyr Glu Arg Tyr Gln Asp Gln Gly Phe Glu Ile Leu Asp Phe Pro Cys 

    50                  55                  60                  

Asn Gln Phe Met Gly Gln Ala Pro Gly Ser Ala Glu Glu Ile Asn Ala 
65                  70                  75                  80  

Phe Cys Ser Leu His Phe Gln Thr Thr Phe Pro Arg Phe Ala Lys Ile 
                85                  90                  95      

Lys Val Asn Gly Lys Glu Ala Asp Pro Leu Tyr Val Trp Leu Gln Asp 
            100                 105                 110         

Gln Lys Ser Gly Pro Leu Gly Lys Arg Val Glu Trp Asn Phe Ala Lys 
        115                 120                 125             

Phe Leu Ile Gly Arg Asp Gly Gln Val Phe Glu Arg Phe Ser Ser Lys 
    130                 135                 140                 

Thr Asp Pro Lys Gln Ile Glu Glu Ala Ile Gln Thr Leu Leu 
145                 150                 155             

<210>   459
<211>   3231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   459
ttgattttac aatatgttta ttggagtgta tacatgcaaa caaaaacaaa gaagctcatt   60
gtgagtttgt cttcacttgt tttatcagga tttttattaa accattatat gacaattgga   120
gcggaagaaa cgactacgaa taccattcag caaagccaga aggaagttca gtatcagcaa   180
agggatacaa aaaatttagt tgaaaatggt gattttggtc agacggagga cggaagcagt   240
ccgtggacag gaagcaaagc tcaggggtgg tcagcttggg tagaccagaa gaatagtgca   300
gatgcctcaa ctcgagtcat tgaggctaag gatggggcta tcactatctc aagccatgag   360
aaattaaggg cagcgcttca ccgtatggtt cctattgaag ctaagaaaaa gtataaactg   420
cgtttcaaga ttaaaacaga taataaaatc gggattgcca aagttcgtat cattgaggaa   480
agtggtaagg acaagcgatt gtggaattct gcaacgacgt caggaacaaa ggactggcag   540
accattgaag cagactatag cccgacttta gatgttgata aaatcaagct ggagttattc   600
tatgaaacag gaactgggac tgtttccttt aaggatattg agctggtaga ggtagcagac   660
cagctttctg aggattctca aacagataaa cagcttgagg aaaagattga tttaccaatt   720
ggaaaaaaac atgttttttc tcttgcggac tatacttata aggtagaaaa tcctgacgtt   780
gcttcagtca aaaatggaat tttagaacct cttaaggaag ggacaaccaa tgtcattgtc   840
agtaaagatg gcaaggaagt gaaaaagatt cctttgaaga ttctggcctc tgttaaggat   900
gcatacacag accgtttgga tgactggaat ggcatcatcg ctgggaatca atactatgat   960
tctaaaaatg aacagatggc caaattaaac caggaattgg aaggaaaggt agctgatagc   1020
ctatccagta tttcaagtca ggcggaccgc acctatttgt gggaaaaatt ttcaaattat   1080
aaaacgtctg caaatctgac tgccacttat cggaaattgg aggagatggc caagcaagtg   1140
accaatcctt cttctcgtta ttatcaagat gaaactgtcg ttcgaacagt cagggattcc   1200
atggaatgga tgcataaaca tgtctacaat agtgaaaaga gcattgttgg gaactggtgg   1260
gattatgaaa tcggtacacc tcgtgccatc aacaatacct tgtctctgat gaaagaatac   1320
ttctctgatg aggaaattaa aaaatataca gatgtgattg aaaaatttgt accagatccc   1380
gaacatttcc gaaagacgac tgataaccca ttcaaggctc taggtggaaa cttagttgat   1440
atgggaaggg taaaagtaat agctggttta ctgcgtaagg atgatcaaga aatttcttct   1500
accattcgct cgattgagca agtgttcaag ttggtagacc aaggtgaagg tttttatcaa   1560
gatggatcct atatcgacca caccaatgtt gcctatacgg gtgcttatgg gaatgttttg   1620
attgatggcc tgtctcaact gttgccagtc attcaaaaga ccaagaatcc aatcgataaa   1680
gataaaatgc aaaccatgta ccactggatt gataaatcgt ttgctccttt gctggtgaat   1740
ggagagttga tggatatgag tcgtggacgc tcgatcagtc gtgcaaatag cgaggggcac   1800
gtggccgcag tagaagtact aagagggatt caccgaatag cggatatgtc tgaaggagaa   1860
accaaacaat gtttgcagag tcttgtgaag accattgttc aatcggatag ttattatgat   1920
gtctttaaga atttgaagac ttataaggat atcagtttga tgcaatcctt gttaagtgat   1980
gcaggagtcg caagtgttcc aagaccaagt tacctatctg cctttaacaa gatggataaa   2040
acagccatgt acaatgcaga gaaagggttt ggatttggct tgtcactctt ttccagtcgt   2100
accttgaatt acgaacacat gaacaaggaa aataaacgtg gttggtatac gagtgatggg   2160
atgttctatc tttacaatgg cgatttgagt cactatagcg atggctactg gccaacagtt   2220
aatccatata agatgcctgg tacaacagag acggatgcta agagagcgga tagcgataca   2280
ggtaaagttt taccgtctgc tttcgttgga acgagcaaac tagatgatgc caatgcgaca   2340
gcaaccatgg atttcaccaa ctggaatcaa acattgactg ctcataagag ctggtttatg   2400
ctaaaggata agatcgcctt tttaggaagc aatatccaaa acacttcaac agatactgct   2460
gcaactacaa ttgaccagag aaaactggaa tcaggtaatc catataaagt ctatgtcaat   2520
gataaagaag cctcccttac agaacaagaa aaggattatc ctgaaaccca aagtgtcttt   2580
ttagaatcgt tcgattcgaa aaagaatatt ggttactttt tctttaagaa gagttcaatc   2640
agtatgagta aggctttgca aaagggagcc tggaaggata tcaatgaagg acagtcagac   2700
aaggaagttg aaaatgaatt tcttacgatt agtcaggctc ataagcaaaa tagagattct   2760
tatggctata tgctcattcc taacgtggat cgtgccacct tcaatcaaat gataaaagag   2820
ttagaaagta gcctcatcga aaataacgaa acccttcagt ctgtttatga tgctaaacaa   2880
ggagtttggg gcattgtgaa atatgatgat tctgtctcta ctatttccaa ccaattccaa   2940
gttttgaaac gtggagtcta taccattcga aaagaagggg atgaatataa gattgcctac   3000
tataatcctg aaacccagga atcagctcca gatcaggaag tctttaaaaa gctagagcaa   3060
gcagctcagc cacaagtaca gaattcaaaa gaaaaggaaa aatctgaaga ggaaaagaac   3120
cattcggatc aaaagaatct ccctcagaca ggagaaggtc agtcaatctt ggcaagtcta   3180
gggttcttgc tacttggggc attttatcta ttccgtagag gaaagaacaa c            3231

<210>   460
<211>   1077
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hyaluronidase
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15902330 (0.E+01)

<400>   460
Met Ile Leu Gln Tyr Val Tyr Trp Ser Val Tyr Met Gln Thr Lys Thr 
1               5                   10                  15      

Lys Lys Leu Ile Val Ser Leu Ser Ser Leu Val Leu Ser Gly Phe Leu 
            20                  25                  30          

Leu Asn His Tyr Met Thr Ile Gly Ala Glu Glu Thr Thr Thr Asn Thr 
        35                  40                  45              

Ile Gln Gln Ser Gln Lys Glu Val Gln Tyr Gln Gln Arg Asp Thr Lys 
    50                  55                  60                  

Asn Leu Val Glu Asn Gly Asp Phe Gly Gln Thr Glu Asp Gly Ser Ser 
65                  70                  75                  80  

Pro Trp Thr Gly Ser Lys Ala Gln Gly Trp Ser Ala Trp Val Asp Gln 
                85                  90                  95      

Lys Asn Ser Ala Asp Ala Ser Thr Arg Val Ile Glu Ala Lys Asp Gly 
            100                 105                 110         

Ala Ile Thr Ile Ser Ser His Glu Lys Leu Arg Ala Ala Leu His Arg 
        115                 120                 125             

Met Val Pro Ile Glu Ala Lys Lys Lys Tyr Lys Leu Arg Phe Lys Ile 
    130                 135                 140                 

Lys Thr Asp Asn Lys Ile Gly Ile Ala Lys Val Arg Ile Ile Glu Glu 
145                 150                 155                 160 

Ser Gly Lys Asp Lys Arg Leu Trp Asn Ser Ala Thr Thr Ser Gly Thr 
                165                 170                 175     

Lys Asp Trp Gln Thr Ile Glu Ala Asp Tyr Ser Pro Thr Leu Asp Val 
            180                 185                 190         

Asp Lys Ile Lys Leu Glu Leu Phe Tyr Glu Thr Gly Thr Gly Thr Val 
        195                 200                 205             

Ser Phe Lys Asp Ile Glu Leu Val Glu Val Ala Asp Gln Leu Ser Glu 
    210                 215                 220                 

Asp Ser Gln Thr Asp Lys Gln Leu Glu Glu Lys Ile Asp Leu Pro Ile 
225                 230                 235                 240 

Gly Lys Lys His Val Phe Ser Leu Ala Asp Tyr Thr Tyr Lys Val Glu 
                245                 250                 255     

Asn Pro Asp Val Ala Ser Val Lys Asn Gly Ile Leu Glu Pro Leu Lys 
            260                 265                 270         

Glu Gly Thr Thr Asn Val Ile Val Ser Lys Asp Gly Lys Glu Val Lys 
        275                 280                 285             

Lys Ile Pro Leu Lys Ile Leu Ala Ser Val Lys Asp Ala Tyr Thr Asp 
    290                 295                 300                 

Arg Leu Asp Asp Trp Asn Gly Ile Ile Ala Gly Asn Gln Tyr Tyr Asp 
305                 310                 315                 320 

Ser Lys Asn Glu Gln Met Ala Lys Leu Asn Gln Glu Leu Glu Gly Lys 
                325                 330                 335     

Val Ala Asp Ser Leu Ser Ser Ile Ser Ser Gln Ala Asp Arg Thr Tyr 
            340                 345                 350         

Leu Trp Glu Lys Phe Ser Asn Tyr Lys Thr Ser Ala Asn Leu Thr Ala 
        355                 360                 365             

Thr Tyr Arg Lys Leu Glu Glu Met Ala Lys Gln Val Thr Asn Pro Ser 
    370                 375                 380                 

Ser Arg Tyr Tyr Gln Asp Glu Thr Val Val Arg Thr Val Arg Asp Ser 
385                 390                 395                 400 

Met Glu Trp Met His Lys His Val Tyr Asn Ser Glu Lys Ser Ile Val 
                405                 410                 415     

Gly Asn Trp Trp Asp Tyr Glu Ile Gly Thr Pro Arg Ala Ile Asn Asn 
            420                 425                 430         

Thr Leu Ser Leu Met Lys Glu Tyr Phe Ser Asp Glu Glu Ile Lys Lys 
        435                 440                 445             

Tyr Thr Asp Val Ile Glu Lys Phe Val Pro Asp Pro Glu His Phe Arg 
    450                 455                 460                 

Lys Thr Thr Asp Asn Pro Phe Lys Ala Leu Gly Gly Asn Leu Val Asp 
465                 470                 475                 480 

Met Gly Arg Val Lys Val Ile Ala Gly Leu Leu Arg Lys Asp Asp Gln 
                485                 490                 495     

Glu Ile Ser Ser Thr Ile Arg Ser Ile Glu Gln Val Phe Lys Leu Val 
            500                 505                 510         

Asp Gln Gly Glu Gly Phe Tyr Gln Asp Gly Ser Tyr Ile Asp His Thr 
        515                 520                 525             

Asn Val Ala Tyr Thr Gly Ala Tyr Gly Asn Val Leu Ile Asp Gly Leu 
    530                 535                 540                 

Ser Gln Leu Leu Pro Val Ile Gln Lys Thr Lys Asn Pro Ile Asp Lys 
545                 550                 555                 560 

Asp Lys Met Gln Thr Met Tyr His Trp Ile Asp Lys Ser Phe Ala Pro 
                565                 570                 575     

Leu Leu Val Asn Gly Glu Leu Met Asp Met Ser Arg Gly Arg Ser Ile 
            580                 585                 590         

Ser Arg Ala Asn Ser Glu Gly His Val Ala Ala Val Glu Val Leu Arg 
        595                 600                 605             

Gly Ile His Arg Ile Ala Asp Met Ser Glu Gly Glu Thr Lys Gln Cys 
    610                 615                 620                 

Leu Gln Ser Leu Val Lys Thr Ile Val Gln Ser Asp Ser Tyr Tyr Asp 
625                 630                 635                 640 

Val Phe Lys Asn Leu Lys Thr Tyr Lys Asp Ile Ser Leu Met Gln Ser 
                645                 650                 655     

Leu Leu Ser Asp Ala Gly Val Ala Ser Val Pro Arg Pro Ser Tyr Leu 
            660                 665                 670         

Ser Ala Phe Asn Lys Met Asp Lys Thr Ala Met Tyr Asn Ala Glu Lys 
        675                 680                 685             

Gly Phe Gly Phe Gly Leu Ser Leu Phe Ser Ser Arg Thr Leu Asn Tyr 
    690                 695                 700                 

Glu His Met Asn Lys Glu Asn Lys Arg Gly Trp Tyr Thr Ser Asp Gly 
705                 710                 715                 720 

Met Phe Tyr Leu Tyr Asn Gly Asp Leu Ser His Tyr Ser Asp Gly Tyr 
                725                 730                 735     

Trp Pro Thr Val Asn Pro Tyr Lys Met Pro Gly Thr Thr Glu Thr Asp 
            740                 745                 750         

Ala Lys Arg Ala Asp Ser Asp Thr Gly Lys Val Leu Pro Ser Ala Phe 
        755                 760                 765             

Val Gly Thr Ser Lys Leu Asp Asp Ala Asn Ala Thr Ala Thr Met Asp 
    770                 775                 780                 

Phe Thr Asn Trp Asn Gln Thr Leu Thr Ala His Lys Ser Trp Phe Met 
785                 790                 795                 800 

Leu Lys Asp Lys Ile Ala Phe Leu Gly Ser Asn Ile Gln Asn Thr Ser 
                805                 810                 815     

Thr Asp Thr Ala Ala Thr Thr Ile Asp Gln Arg Lys Leu Glu Ser Gly 
            820                 825                 830         

Asn Pro Tyr Lys Val Tyr Val Asn Asp Lys Glu Ala Ser Leu Thr Glu 
        835                 840                 845             

Gln Glu Lys Asp Tyr Pro Glu Thr Gln Ser Val Phe Leu Glu Ser Phe 
    850                 855                 860                 

Asp Ser Lys Lys Asn Ile Gly Tyr Phe Phe Phe Lys Lys Ser Ser Ile 
865                 870                 875                 880 

Ser Met Ser Lys Ala Leu Gln Lys Gly Ala Trp Lys Asp Ile Asn Glu 
                885                 890                 895     

Gly Gln Ser Asp Lys Glu Val Glu Asn Glu Phe Leu Thr Ile Ser Gln 
            900                 905                 910         

Ala His Lys Gln Asn Arg Asp Ser Tyr Gly Tyr Met Leu Ile Pro Asn 
        915                 920                 925             

Val Asp Arg Ala Thr Phe Asn Gln Met Ile Lys Glu Leu Glu Ser Ser 
    930                 935                 940                 

Leu Ile Glu Asn Asn Glu Thr Leu Gln Ser Val Tyr Asp Ala Lys Gln 
945                 950                 955                 960 

Gly Val Trp Gly Ile Val Lys Tyr Asp Asp Ser Val Ser Thr Ile Ser 
                965                 970                 975     

Asn Gln Phe Gln Val Leu Lys Arg Gly Val Tyr Thr Ile Arg Lys Glu 
            980                 985                 990         

Gly Asp Glu Tyr Lys Ile Ala Tyr Tyr Asn Pro Glu Thr Gln Glu Ser 
        995                 1000                1005            

Ala Pro Asp Gln Glu Val Phe Lys Lys Leu Glu Gln Ala Ala Gln Pro 
    1010                1015                1020                

Gln Val Gln Asn Ser Lys Glu Lys Glu Lys Ser Glu Glu Glu Lys Asn 
1025                1030                1035                1040

His Ser Asp Gln Lys Asn Leu Pro Gln Thr Gly Glu Gly Gln Ser Ile 
                1045                1050                1055    

Leu Ala Ser Leu Gly Phe Leu Leu Leu Gly Ala Phe Tyr Leu Phe Arg 
            1060                1065                1070        

Arg Gly Lys Asn Asn 
        1075        

<210>   461
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   461
gtggtttatc tcagagctat aagcccaaat catcagccag cgcctaaaga cgctggcttt   60
cacgttgttc aagccttatt gctcttgact cgtcacttgc ctctt                   105

<210>   462
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   462
Met Val Tyr Leu Arg Ala Ile Ser Pro Asn His Gln Pro Ala Pro Lys 
1               5                   10                  15      

Asp Ala Gly Phe His Val Val Gln Ala Leu Leu Leu Leu Thr Arg His 
            20                  25                  30          

Leu Pro Leu 
        35  

<210>   463
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   463
atgaccaaat cagatacgat tattgaacta aaaaaacaaa aaattgtcgc tgttattcga   60
ggaaatacaa aggaagaagg actacaagcc tcgattgctt gtatcaaggg cggtatcaaa   120
gctattgaaa tcgcctatac caatcagtat gcaggacaaa tcatcaagga acttgtagac   180
ttgtatcagg acgatcagag tgtttgtatc ggtgcaggta ctgtgcttga tgccgtaact   240
gctagagatg ccattctagc tggagcaaat tacgttgttt ctccatcttt ccatgctgaa   300
actgcgaaaa tgtgcaatct ctacagcaca ccgtacattc caggctgtat taccctcaca   360
gagatcacga ctgcacttga agccggtagt gaaatcatca aactcttccc aggtagtact   420
ctcagtccag catatatctc tgcagtcaag gcaccgatcc cacaagtttc cgtaatggta   480
accggaggag tcggcctaaa caacatccct caatggttcg ctgctggtgc agatgccgtt   540
ggaattggtg gcgaactcaa taaactcgct tcccaaggca actttgaccg catcagcgag   600
attgcccaac agtatattac actcaga                                       627

<210>   464
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldo
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902331 (e-114)

<400>   464
Met Thr Lys Ser Asp Thr Ile Ile Glu Leu Lys Lys Gln Lys Ile Val 
1               5                   10                  15      

Ala Val Ile Arg Gly Asn Thr Lys Glu Glu Gly Leu Gln Ala Ser Ile 
            20                  25                  30          

Ala Cys Ile Lys Gly Gly Ile Lys Ala Ile Glu Ile Ala Tyr Thr Asn 
        35                  40                  45              

Gln Tyr Ala Gly Gln Ile Ile Lys Glu Leu Val Asp Leu Tyr Gln Asp 
    50                  55                  60                  

Asp Gln Ser Val Cys Ile Gly Ala Gly Thr Val Leu Asp Ala Val Thr 
65                  70                  75                  80  

Ala Arg Asp Ala Ile Leu Ala Gly Ala Asn Tyr Val Val Ser Pro Ser 
                85                  90                  95      

Phe His Ala Glu Thr Ala Lys Met Cys Asn Leu Tyr Ser Thr Pro Tyr 
            100                 105                 110         

Ile Pro Gly Cys Ile Thr Leu Thr Glu Ile Thr Thr Ala Leu Glu Ala 
        115                 120                 125             

Gly Ser Glu Ile Ile Lys Leu Phe Pro Gly Ser Thr Leu Ser Pro Ala 
    130                 135                 140                 

Tyr Ile Ser Ala Val Lys Ala Pro Ile Pro Gln Val Ser Val Met Val 
145                 150                 155                 160 

Thr Gly Gly Val Gly Leu Asn Asn Ile Pro Gln Trp Phe Ala Ala Gly 
                165                 170                 175     

Ala Asp Ala Val Gly Ile Gly Gly Glu Leu Asn Lys Leu Ala Ser Gln 
            180                 185                 190         


Gly Asn Phe Asp Arg Ile Ser Glu Ile Ala Gln Gln Tyr Ile Thr Leu 
        195                 200                 205             

Arg 
    

<210>   465
<211>   999
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   465
atgacgaaaa tattactgtt tggcgaacca ttaattcgaa tttcaccatt agatgccacc   60
agtatcggcg atcatgttgc cagttcgact tattttggcg gatcagaaat taacatcgct   120
tgtaatttgc aagccctggg tatctcaacg aaagttttta ccgcactccc tgccaacgag   180
attggagatc gttttctcac attcttgaaa cagcaccaaa tcgataccag ttcaatctgt   240
cggcttggcg atcgaatcgg cctctactat ttggagaacg gctttggttg tcgtcaaagt   300
gaagttttct acgatcgtaa gcatacgagt atcagccaga ttcggccaaa catgctagat   360
atggattctc tctttcaggg gattagccat tttcatttta gtggaatcac cgtagctatc   420
ggtcaagagg tccgtgcgat ccttctccta ctcttggaag aagccaagcg ccgaggaatt   480
gtcgtttcaa tggatctcaa tctgagaaca aagatgattt cagtcctaga agccaagtat   540
gaattttcta agtttgcacg ttttactgac tattgcttcg gtattgatcc tctcatgatt   600
gatgaccaaa atctagagat gtttccaaga gacagtgcta gcctagaaga ggtggaaaat   660
cgcatgcgac ttttaaaaga agcctatggt ttcaaggcca ttttccatac cctccgctct   720
agtgatgagc aagacaaaaa tgtctatcaa gcctatgctc tagaagaact atttgaagag   780
tctgtccaac taaaaactgc agtctatcaa cgaattggta gcggggatgc ctttatatct   840
ggtgcccttt accaactact ccatcattcc tccctaaaaa ctaccattga ctttgcagtt   900
gcgagcgcaa ctctcaaatg cactcttcca ggagaccatc tctccacttc ctcaactagt   960
attgaaaatt tactggcaaa tgcacaagat atcattcgt                          999

<210>   466
<211>   333
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   carbohydrate kinase, PfkB family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902332 (0.E+01)

<400>   466
Met Thr Lys Ile Leu Leu Phe Gly Glu Pro Leu Ile Arg Ile Ser Pro 
1               5                   10                  15      

Leu Asp Ala Thr Ser Ile Gly Asp His Val Ala Ser Ser Thr Tyr Phe 
            20                  25                  30          

Gly Gly Ser Glu Ile Asn Ile Ala Cys Asn Leu Gln Ala Leu Gly Ile 
        35                  40                  45              

Ser Thr Lys Val Phe Thr Ala Leu Pro Ala Asn Glu Ile Gly Asp Arg 
    50                  55                  60                  

Phe Leu Thr Phe Leu Lys Gln His Gln Ile Asp Thr Ser Ser Ile Cys 
65                  70                  75                  80  

Arg Leu Gly Asp Arg Ile Gly Leu Tyr Tyr Leu Glu Asn Gly Phe Gly 
                85                  90                  95      

Cys Arg Gln Ser Glu Val Phe Tyr Asp Arg Lys His Thr Ser Ile Ser 
            100                 105                 110         

Gln Ile Arg Pro Asn Met Leu Asp Met Asp Ser Leu Phe Gln Gly Ile 
        115                 120                 125             

Ser His Phe His Phe Ser Gly Ile Thr Val Ala Ile Gly Gln Glu Val 
    130                 135                 140                 

Arg Ala Ile Leu Leu Leu Leu Leu Glu Glu Ala Lys Arg Arg Gly Ile 
145                 150                 155                 160 

Val Val Ser Met Asp Leu Asn Leu Arg Thr Lys Met Ile Ser Val Leu 
                165                 170                 175     

Glu Ala Lys Tyr Glu Phe Ser Lys Phe Ala Arg Phe Thr Asp Tyr Cys 
            180                 185                 190         

Phe Gly Ile Asp Pro Leu Met Ile Asp Asp Gln Asn Leu Glu Met Phe 
        195                 200                 205             

Pro Arg Asp Ser Ala Ser Leu Glu Glu Val Glu Asn Arg Met Arg Leu 
    210                 215                 220                 

Leu Lys Glu Ala Tyr Gly Phe Lys Ala Ile Phe His Thr Leu Arg Ser 
225                 230                 235                 240 

Ser Asp Glu Gln Asp Lys Asn Val Tyr Gln Ala Tyr Ala Leu Glu Glu 
                245                 250                 255     

Leu Phe Glu Glu Ser Val Gln Leu Lys Thr Ala Val Tyr Gln Arg Ile 
            260                 265                 270         

Gly Ser Gly Asp Ala Phe Ile Ser Gly Ala Leu Tyr Gln Leu Leu His 
        275                 280                 285             

His Ser Ser Leu Lys Thr Thr Ile Asp Phe Ala Val Ala Ser Ala Thr 
    290                 295                 300                 

Leu Lys Cys Thr Leu Pro Gly Asp His Leu Ser Thr Ser Ser Thr Ser 
305                 310                 315                 320 

Ile Glu Asn Leu Leu Ala Asn Ala Gln Asp Ile Ile Arg 
                325                 330             

<210>   467
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   467
atgaaaatcg cattaatcaa tgaaaatagt caagctagca agaatcacat tatttacgat   60
agtctaaaag aagcgacaga taaaaaaggc taccaattat ttaactatgg tatgcgtgga   120
gaagaaggag aaagtcaatt aacttatgtg cagaacggac taatggctgc catcctttta   180
aatacaaagg cagttgactt tgttgttacc ggctgtggta cgggtgtagg ggctatgctt   240
gctttaaaca gcttccctgg tgttgtctgt ggtctagcag tggacccaac tgacgcttac   300
ctttattctc aaatcaatgg tggtaacgcc ttgtctatcc cttatgccaa aggatttggc   360
tggggggcag aactgaccct caaattgatg tttgaacgct tatttgctga agaaatgggc   420
ggtggctacc caagagaacg tgtaatccct gaacaacgca acgctcgtat cttaaacgag   480
gtgaaacaaa tcacccacaa tgatttgatg accatcctta aaataatcga ccaagacttc   540
ctcaaagaca ccatctctgg caaatacttc caagaatact tctttgaaaa ctgccaagat   600
gatgaagttg ctgcttattt gaaagaagta ttagccaag                          639

<210>   468
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902333 (e-120)

<400>   468
Met Lys Ile Ala Leu Ile Asn Glu Asn Ser Gln Ala Ser Lys Asn His 
1               5                   10                  15      

Ile Ile Tyr Asp Ser Leu Lys Glu Ala Thr Asp Lys Lys Gly Tyr Gln 
            20                  25                  30          

Leu Phe Asn Tyr Gly Met Arg Gly Glu Glu Gly Glu Ser Gln Leu Thr 
        35                  40                  45              

Tyr Val Gln Asn Gly Leu Met Ala Ala Ile Leu Leu Asn Thr Lys Ala 
    50                  55                  60                  

Val Asp Phe Val Val Thr Gly Cys Gly Thr Gly Val Gly Ala Met Leu 
65                  70                  75                  80  

Ala Leu Asn Ser Phe Pro Gly Val Val Cys Gly Leu Ala Val Asp Pro 
                85                  90                  95      

Thr Asp Ala Tyr Leu Tyr Ser Gln Ile Asn Gly Gly Asn Ala Leu Ser 
            100                 105                 110         

Ile Pro Tyr Ala Lys Gly Phe Gly Trp Gly Ala Glu Leu Thr Leu Lys 
        115                 120                 125             

Leu Met Phe Glu Arg Leu Phe Ala Glu Glu Met Gly Gly Gly Tyr Pro 
    130                 135                 140                 

Arg Glu Arg Val Ile Pro Glu Gln Arg Asn Ala Arg Ile Leu Asn Glu 
145                 150                 155                 160 

Val Lys Gln Ile Thr His Asn Asp Leu Met Thr Ile Leu Lys Ile Ile 
                165                 170                 175     

Asp Gln Asp Phe Leu Lys Asp Thr Ile Ser Gly Lys Tyr Phe Gln Glu 
            180                 185                 190         

Tyr Phe Phe Glu Asn Cys Gln Asp Asp Glu Val Ala Ala Tyr Leu Lys 
        195                 200                 205             

Glu Val Leu Ala Lys 
    210             

<210>   469
<211>   813
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   469
atgacaaata catcattctc aattgagcag ttttctttaa aaggaaaaat tgctctcatc   60
accggcgctt cttatggaat tggatttgct attgccaaat cctacgctga agccggcgct   120
actattgtct ttaacgatat caatcaagat ctggtcaata aagggattga agcttatcgt   180
gaagttggca tccaagccca tggatatgtc tgtgacgtga cagacgagga cggtatccaa   240
gccatggtca agcaaatcga acaagaggtt ggtgtcattg acatcctcgt taataacgct   300
ggtattatcc gccgagttcc aatgtgcgaa atgagcgccg ctgatttccg taaggtcatc   360
gatattgact taaacgcacc atttatcgtt tcaaaggcag ttattccttc tatgataaag   420
aaagggcatg gaaagattat caatatttgt tcgatgatga gcgaactggg acgtgaaaca   480
gttagcgctt atgctgctgc taaagggggc ttgaaaatgt tgacccgcaa cattgcgtct   540
gaatacggtg gagccaatat ccaatgtaac ggaattggac cgggttatat tgccactcct   600
caaacagcac ctcttcgtga attgcaagaa gatggttctc gccacccatt tgaccagttc   660
atcattgcaa aaacacctgc tgcacgttgg ggaaatactg aagatttgat gggccctgct   720
gtctttctcg ctagtgatgc cagcaatttt gtcaatggcc acatcctata tgtagatggc   780
ggtatcttag cctacatcgg aaaacaacct gag                                813

<210>   470
<211>   271
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, short chain dehydrogenase/reductase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902334 (e-153)

<400>   470
Met Thr Asn Thr Ser Phe Ser Ile Glu Gln Phe Ser Leu Lys Gly Lys 
1               5                   10                  15      

Ile Ala Leu Ile Thr Gly Ala Ser Tyr Gly Ile Gly Phe Ala Ile Ala 
            20                  25                  30          

Lys Ser Tyr Ala Glu Ala Gly Ala Thr Ile Val Phe Asn Asp Ile Asn 
        35                  40                  45              

Gln Asp Leu Val Asn Lys Gly Ile Glu Ala Tyr Arg Glu Val Gly Ile 
    50                  55                  60                  

Gln Ala His Gly Tyr Val Cys Asp Val Thr Asp Glu Asp Gly Ile Gln 
65                  70                  75                  80  

Ala Met Val Lys Gln Ile Glu Gln Glu Val Gly Val Ile Asp Ile Leu 
                85                  90                  95      

Val Asn Asn Ala Gly Ile Ile Arg Arg Val Pro Met Cys Glu Met Ser 
            100                 105                 110         

Ala Ala Asp Phe Arg Lys Val Ile Asp Ile Asp Leu Asn Ala Pro Phe 
        115                 120                 125             

Ile Val Ser Lys Ala Val Ile Pro Ser Met Ile Lys Lys Gly His Gly 
    130                 135                 140                 

Lys Ile Ile Asn Ile Cys Ser Met Met Ser Glu Leu Gly Arg Glu Thr 
145                 150                 155                 160 

Val Ser Ala Tyr Ala Ala Ala Lys Gly Gly Leu Lys Met Leu Thr Arg 
                165                 170                 175     

Asn Ile Ala Ser Glu Tyr Gly Gly Ala Asn Ile Gln Cys Asn Gly Ile 
            180                 185                 190         

Gly Pro Gly Tyr Ile Ala Thr Pro Gln Thr Ala Pro Leu Arg Glu Leu 
        195                 200                 205             

Gln Glu Asp Gly Ser Arg His Pro Phe Asp Gln Phe Ile Ile Ala Lys 
    210                 215                 220                 

Thr Pro Ala Ala Arg Trp Gly Asn Thr Glu Asp Leu Met Gly Pro Ala 
225                 230                 235                 240 

Val Phe Leu Ala Ser Asp Ala Ser Asn Phe Val Asn Gly His Ile Leu 
                245                 250                 255     

Tyr Val Asp Gly Gly Ile Leu Ala Tyr Ile Gly Lys Gln Pro Glu 
            260                 265                 270     

<210>   471
<211>   432
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   471
atgaaaattg tacttgtagg gcatggacat tttgctacag ggatttatag ttctttacaa   60
ttgattgcag gtaatcaaga aaatgtggag gcgattgact ttgtggaagg aatgtcagca   120
gatgaactca agcaaaaaat cttacttgca atttcaaatg aagaagaagt tttaatccta   180
agtgatctct tgggaggatc gccattcaag gtttcttcta ccataatggg agaaaatcca   240
gccaagacaa tgaatgttct ctcgggtttg aacttagcca tgttaatgga agcagtcttt   300
gctagaatgg ctcatagctt tgatgaggtt gttaataaat cagtagtggc ggcccagggc   360
ggagtcgtaa atggtaaaga attgttttca acggatgcag aggaagagga agaagatttc   420
gaatcgggta tt                                                       432

<210>   472
<211>   144
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIA component
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902335 (4.E-76)

<400>   472
Met Lys Ile Val Leu Val Gly His Gly His Phe Ala Thr Gly Ile Tyr 
1               5                   10                  15      

Ser Ser Leu Gln Leu Ile Ala Gly Asn Gln Glu Asn Val Glu Ala Ile 
            20                  25                  30          

Asp Phe Val Glu Gly Met Ser Ala Asp Glu Leu Lys Gln Lys Ile Leu 
        35                  40                  45              

Leu Ala Ile Ser Asn Glu Glu Glu Val Leu Ile Leu Ser Asp Leu Leu 
    50                  55                  60                  

Gly Gly Ser Pro Phe Lys Val Ser Ser Thr Ile Met Gly Glu Asn Pro 
65                  70                  75                  80  

Ala Lys Thr Met Asn Val Leu Ser Gly Leu Asn Leu Ala Met Leu Met 
                85                  90                  95      

Glu Ala Val Phe Ala Arg Met Ala His Ser Phe Asp Glu Val Val Asn 
            100                 105                 110         

Lys Ser Val Val Ala Ala Gln Gly Gly Val Val Asn Gly Lys Glu Leu 
        115                 120                 125             

Phe Ser Thr Asp Ala Glu Glu Glu Glu Glu Asp Phe Glu Ser Gly Ile 
    130                 135                 140                 


<210>   473
<211>   1188
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   473
atgataaaaa aggttacgat tgaaaaaata aaatcgcctg agcgcttctt agaagtacca   60
cttctgacga aagaagaagt cggccaggca atcgataagg ttattcggca gttagaactc   120
aaccttgact atttcaagga agatttcccg acgccagcta cctttgataa tgtctatcca   180
atcatggata acacggaatg gaccaatggt ttctggacag gagaactgtg gttggcttat   240
gaatacagtc aacaggatgc atttaaaaac atcgctcata aaaatgttct ttctttcctg   300
gatcgtgtca ataagagagt agaattggat caccatgatc tcggcttctt gtacacaccg   360
tcttgtatgg ctgaatataa gataaatgga gatggagagg ctagagaagc aaccttgaaa   420
gctgcagata agttgattga acgctatcaa gaaaaaggtg gttttattca agcttgggga   480
gacttgggca agaaagagca ttaccgtttg attatcgact gcttgctcaa tatccaactc   540
ttattctttg cttatcaaga aacaggcgat caaaaatact acgatattgc agaaagccat   600
ttctatgctt cagctaataa tgtaatccgt gatgacgctt cgtccttcca caccttctat   660
tttgatcctg agacaggtca accctttaaa ggtgtaacga gacaagggta tagtgatgat   720
tcatgctggg cacgtggtca atcatgggga gtctatggta ttcctttgac ttatcgtcac   780
ttaaaagacg agtcctgctt tgacttgttt aagggtgtga ccaattattt cttgaatcgt   840
ctgccaaaag atcatgtgtc ctattgggat ttgattttta atgatggtag tgatcaatca   900
cgagattctt cagcaacagc tatcgccgtc tgtgggattc atgaaatgct aaaacatctc   960
ccagaggtgg atgctgacaa agatatttat aaacatgcta tgcatgccat gcttcgttcc   1020
ttgatcgaac attatgcaaa tgatcaattt acccctggtg ggacaagtct cctccacggt   1080
gtgtactcat ggcattcagg taaaggagtg gatgaaggca atatctgggg tgactactat   1140
tacctagaag cccttatccg tttctacaaa gactggaacc tatattgg                1188

<210>   474
<211>   396
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucuronyl hydrolase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902336 (0.E+01)

<400>   474
Met Ile Lys Lys Val Thr Ile Glu Lys Ile Lys Ser Pro Glu Arg Phe 
1               5                   10                  15      


Leu Glu Val Pro Leu Leu Thr Lys Glu Glu Val Gly Gln Ala Ile Asp 
            20                  25                  30          

Lys Val Ile Arg Gln Leu Glu Leu Asn Leu Asp Tyr Phe Lys Glu Asp 
        35                  40                  45              

Phe Pro Thr Pro Ala Thr Phe Asp Asn Val Tyr Pro Ile Met Asp Asn 
    50                  55                  60                  

Thr Glu Trp Thr Asn Gly Phe Trp Thr Gly Glu Leu Trp Leu Ala Tyr 
65                  70                  75                  80  

Glu Tyr Ser Gln Gln Asp Ala Phe Lys Asn Ile Ala His Lys Asn Val 
                85                  90                  95      

Leu Ser Phe Leu Asp Arg Val Asn Lys Arg Val Glu Leu Asp His His 
            100                 105                 110         

Asp Leu Gly Phe Leu Tyr Thr Pro Ser Cys Met Ala Glu Tyr Lys Ile 
        115                 120                 125             

Asn Gly Asp Gly Glu Ala Arg Glu Ala Thr Leu Lys Ala Ala Asp Lys 
    130                 135                 140                 

Leu Ile Glu Arg Tyr Gln Glu Lys Gly Gly Phe Ile Gln Ala Trp Gly 
145                 150                 155                 160 

Asp Leu Gly Lys Lys Glu His Tyr Arg Leu Ile Ile Asp Cys Leu Leu 
                165                 170                 175     

Asn Ile Gln Leu Leu Phe Phe Ala Tyr Gln Glu Thr Gly Asp Gln Lys 
            180                 185                 190         

Tyr Tyr Asp Ile Ala Glu Ser His Phe Tyr Ala Ser Ala Asn Asn Val 
        195                 200                 205             

Ile Arg Asp Asp Ala Ser Ser Phe His Thr Phe Tyr Phe Asp Pro Glu 
    210                 215                 220                 

Thr Gly Gln Pro Phe Lys Gly Val Thr Arg Gln Gly Tyr Ser Asp Asp 
225                 230                 235                 240 

Ser Cys Trp Ala Arg Gly Gln Ser Trp Gly Val Tyr Gly Ile Pro Leu 
                245                 250                 255     

Thr Tyr Arg His Leu Lys Asp Glu Ser Cys Phe Asp Leu Phe Lys Gly 
            260                 265                 270         

Val Thr Asn Tyr Phe Leu Asn Arg Leu Pro Lys Asp His Val Ser Tyr 
        275                 280                 285             

Trp Asp Leu Ile Phe Asn Asp Gly Ser Asp Gln Ser Arg Asp Ser Ser 
    290                 295                 300                 

Ala Thr Ala Ile Ala Val Cys Gly Ile His Glu Met Leu Lys His Leu 
305                 310                 315                 320 

Pro Glu Val Asp Ala Asp Lys Asp Ile Tyr Lys His Ala Met His Ala 
                325                 330                 335     

Met Leu Arg Ser Leu Ile Glu His Tyr Ala Asn Asp Gln Phe Thr Pro 
            340                 345                 350         

Gly Gly Thr Ser Leu Leu His Gly Val Tyr Ser Trp His Ser Gly Lys 
        355                 360                 365             

Gly Val Asp Glu Gly Asn Ile Trp Gly Asp Tyr Tyr Tyr Leu Glu Ala 
    370                 375                 380                 

Leu Ile Arg Phe Tyr Lys Asp Trp Asn Leu Tyr Trp 
385                 390                 395     

<210>   475
<211>   489
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   475
atgacaatgc caaatattat tatgacccgt atcgatgaac ggttgattca tggacaagga   60
caactttggg taaaatacct aggttgtaat acggtcattg ttgccaatga cgaagtaagc   120
acggacaaga tgcaacaaac tctgatgaaa acagttgtgc cagactcagt tgccatgcgt   180
ttcttccctt tgcaaaaggt gattgatatc attcacaagg ctaatcctgc tcaaacgatc   240
tttatcgttg taaaggatgt gaaggacgct ttaaccttgg tagaaggtgg tgtcactatc   300
aaagaaatca atattgggaa cattcacaat gcccctggta aagagcaagt gacacgctcc   360
atcttcctgg gtgaagagga caaggcggcc ctcaaggaat tgagccaaac tcatcaagta   420
acatttaata cgaaaacaac tccaacagga aatgatggag ctgttcaagt caacattatg   480
gactatatt                                                           489

<210>   476
<211>   163
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIB component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902337 (6.E-90)

<400>   476
Met Thr Met Pro Asn Ile Ile Met Thr Arg Ile Asp Glu Arg Leu Ile 
1               5                   10                  15      

His Gly Gln Gly Gln Leu Trp Val Lys Tyr Leu Gly Cys Asn Thr Val 
            20                  25                  30          

Ile Val Ala Asn Asp Glu Val Ser Thr Asp Lys Met Gln Gln Thr Leu 
        35                  40                  45              

Met Lys Thr Val Val Pro Asp Ser Val Ala Met Arg Phe Phe Pro Leu 
    50                  55                  60                  

Gln Lys Val Ile Asp Ile Ile His Lys Ala Asn Pro Ala Gln Thr Ile 
65                  70                  75                  80  

Phe Ile Val Val Lys Asp Val Lys Asp Ala Leu Thr Leu Val Glu Gly 
                85                  90                  95      


Gly Val Thr Ile Lys Glu Ile Asn Ile Gly Asn Ile His Asn Ala Pro 
            100                 105                 110         

Gly Lys Glu Gln Val Thr Arg Ser Ile Phe Leu Gly Glu Glu Asp Lys 
        115                 120                 125             

Ala Ala Leu Lys Glu Leu Ser Gln Thr His Gln Val Thr Phe Asn Thr 
    130                 135                 140                 

Lys Thr Thr Pro Thr Gly Asn Asp Gly Ala Val Gln Val Asn Ile Met 
145                 150                 155                 160 

Asp Tyr Ile 
            

<210>   477
<211>   777
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   477
atgtcgatta atgtatttca agcgatttta attggattat ggacagcttt ctgttttagt   60
ggaatgctgt taggaattta caccaataga tgtattgttc tgtcatttgg tgtcggaatt   120
attctaggtg atctgcctac tgctcttgca atgggagcta ttggtgaatt ggcttatatg   180
ggattcggtg ttggtgctgg aggtactgtt ccaccaaacc caatcggacc tggtatcttt   240
ggtaccttga tggctatcac tagtgctggt aaagtcagtc cagaagcggc tcttgccctc   300
tctactccga ttgctgtggc gattcaattc ttacaaactt tcgcctacac tgtacgtgct   360
ggtgcgcctg aaacagctat gaagcacttg aaaaaccata atttgaagaa atttaagttc   420
actctaaatg caacaatttg gttgtttgcc tttattggat ttaccttggg ttgcttgggt   480
gccctttcaa tggatacctt gttgaaactc gtagactaca ttccaccggt attacttaca   540
ggtttgacag ttgctggtaa aatgctccca gctatcggtt ttgcgatgat cttgtcagtg   600
atggctaaga aagagttgat tccctttgtc ttgttgggat atgtttgtgc agcttatcta   660
aacatcccaa caattggtat tgcaattgta ggtactatct ttgctttgat tgaattttat   720
aacaagccaa aaacagcgga tcatgtggta gaggaggaag cacacgatga ctggatc      777

<210>   478
<211>   259
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIC component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902338 (e-148)

<400>   478
Met Ser Ile Asn Val Phe Gln Ala Ile Leu Ile Gly Leu Trp Thr Ala 
1               5                   10                  15      

Phe Cys Phe Ser Gly Met Leu Leu Gly Ile Tyr Thr Asn Arg Cys Ile 
            20                  25                  30          

Val Leu Ser Phe Gly Val Gly Ile Ile Leu Gly Asp Leu Pro Thr Ala 
        35                  40                  45              

Leu Ala Met Gly Ala Ile Gly Glu Leu Ala Tyr Met Gly Phe Gly Val 
    50                  55                  60                  

Gly Ala Gly Gly Thr Val Pro Pro Asn Pro Ile Gly Pro Gly Ile Phe 
65                  70                  75                  80  

Gly Thr Leu Met Ala Ile Thr Ser Ala Gly Lys Val Ser Pro Glu Ala 
                85                  90                  95      

Ala Leu Ala Leu Ser Thr Pro Ile Ala Val Ala Ile Gln Phe Leu Gln 
            100                 105                 110         

Thr Phe Ala Tyr Thr Val Arg Ala Gly Ala Pro Glu Thr Ala Met Lys 
        115                 120                 125             

His Leu Lys Asn His Asn Leu Lys Lys Phe Lys Phe Thr Leu Asn Ala 
    130                 135                 140                 

Thr Ile Trp Leu Phe Ala Phe Ile Gly Phe Thr Leu Gly Cys Leu Gly 
145                 150                 155                 160 

Ala Leu Ser Met Asp Thr Leu Leu Lys Leu Val Asp Tyr Ile Pro Pro 
                165                 170                 175     

Val Leu Leu Thr Gly Leu Thr Val Ala Gly Lys Met Leu Pro Ala Ile 
            180                 185                 190         

Gly Phe Ala Met Ile Leu Ser Val Met Ala Lys Lys Glu Leu Ile Pro 
        195                 200                 205             

Phe Val Leu Leu Gly Tyr Val Cys Ala Ala Tyr Leu Asn Ile Pro Thr 
    210                 215                 220                 

Ile Gly Ile Ala Ile Val Gly Thr Ile Phe Ala Leu Ile Glu Phe Tyr 
225                 230                 235                 240 

Asn Lys Pro Lys Thr Ala Asp His Val Val Glu Glu Glu Ala His Asp 
                245                 250                 255     

Asp Trp Ile 
            

<210>   479
<211>   816
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   479
atgactggat ctaacaaatt aacaaaacgt gattatctta aaacgtcttt gcgggcattc   60
ttttgtcaaa atggatttaa ctatagtaac tatcaagggt tgggatatgc caatgtgatg   120
tatcctgctt tgaaaaaaca ctatggagag gatcaggaag gtttctacca agccttggaa   180
gaaaactgtg aattctataa taccaaccca cacttcctgc cttttattac cagcttgcat   240
cttgtaatgt tggaaaatgg ccgtccggca aaagaaacac gtagcatcaa gatggccttg   300
atgggaccat tggcaggtat tggggattct ctttctcaat tctgtttagc tccattgttc   360
tcaaccatcg cagcttcgtt tgctcaagaa ggcttggttg tcggtccaat cttgttcttc   420
cttgcgatga atacgatttt aacagcgatt aaattgtcaa ctggtctgta tggatacaaa   480
ctaggaacaa ctgtgattga taaactaagc gaacagatgg caacgatttc tcgtattgcc   540
aatattatcg gtgtaaccgt aattgctggt ttggcagcga catctgttaa gattatggtg   600
ccgattacct ttgctgcagg ggaagttaaa gcagacgcta aacaaagtat cgtaagtatt   660
cagggaatgc ttgataaggt tgctccagct cttctaccag ccctatttac acttttagtt   720
tactacttga tcaaagaaaa gaaatggaca acatataaac tcgttatttt aacagttatc   780
atcggaatta tcggaagctg gcttaagatt atagct                             816

<210>   480
<211>   272
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IID component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902339 (e-153)

<400>   480
Met Thr Gly Ser Asn Lys Leu Thr Lys Arg Asp Tyr Leu Lys Thr Ser 
1               5                   10                  15      

Leu Arg Ala Phe Phe Cys Gln Asn Gly Phe Asn Tyr Ser Asn Tyr Gln 
            20                  25                  30          

Gly Leu Gly Tyr Ala Asn Val Met Tyr Pro Ala Leu Lys Lys His Tyr 
        35                  40                  45              

Gly Glu Asp Gln Glu Gly Phe Tyr Gln Ala Leu Glu Glu Asn Cys Glu 
    50                  55                  60                  

Phe Tyr Asn Thr Asn Pro His Phe Leu Pro Phe Ile Thr Ser Leu His 
65                  70                  75                  80  

Leu Val Met Leu Glu Asn Gly Arg Pro Ala Lys Glu Thr Arg Ser Ile 
                85                  90                  95      

Lys Met Ala Leu Met Gly Pro Leu Ala Gly Ile Gly Asp Ser Leu Ser 
            100                 105                 110         

Gln Phe Cys Leu Ala Pro Leu Phe Ser Thr Ile Ala Ala Ser Phe Ala 
        115                 120                 125             

Gln Glu Gly Leu Val Val Gly Pro Ile Leu Phe Phe Leu Ala Met Asn 
    130                 135                 140                 

Thr Ile Leu Thr Ala Ile Lys Leu Ser Thr Gly Leu Tyr Gly Tyr Lys 
145                 150                 155                 160 

Leu Gly Thr Thr Val Ile Asp Lys Leu Ser Glu Gln Met Ala Thr Ile 
                165                 170                 175     

Ser Arg Ile Ala Asn Ile Ile Gly Val Thr Val Ile Ala Gly Leu Ala 
            180                 185                 190         

Ala Thr Ser Val Lys Ile Met Val Pro Ile Thr Phe Ala Ala Gly Glu 
        195                 200                 205             

Val Lys Ala Asp Ala Lys Gln Ser Ile Val Ser Ile Gln Gly Met Leu 
    210                 215                 220                 

Asp Lys Val Ala Pro Ala Leu Leu Pro Ala Leu Phe Thr Leu Leu Val 
225                 230                 235                 240 

Tyr Tyr Leu Ile Lys Glu Lys Lys Trp Thr Thr Tyr Lys Leu Val Ile 
                245                 250                 255     

Leu Thr Val Ile Ile Gly Ile Ile Gly Ser Trp Leu Lys Ile Ile Ala 
            260                 265                 270         


<210>   481
<211>   291
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   481
atggatacaa cattgtttta tggaatagtg attgtcttgg cagtgagtcc ccttttactg   60
tcaagctttc attctattcg tcagcaaaag ttgcttcgca aacagatgga gcaacgacaa   120
gagtatttag cttctttaac atttggtgat gaagtgttgt tattgtctgg aattcatgga   180
aaaatcattt ctatccaaga tgacttggtc tccttgcaga ttgcaaaagg tgtggtcatc   240
catgtagaaa aggaaagtgt aatgggaaag acaaaagaac tgctttttaa g            291

<210>   482
<211>   97
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   preprotein translocase, YajC subunit (yajC)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902340 (3.E-47)

<400>   482
Met Asp Thr Thr Leu Phe Tyr Gly Ile Val Ile Val Leu Ala Val Ser 
1               5                   10                  15      

Pro Leu Leu Leu Ser Ser Phe His Ser Ile Arg Gln Gln Lys Leu Leu 
            20                  25                  30          

Arg Lys Gln Met Glu Gln Arg Gln Glu Tyr Leu Ala Ser Leu Thr Phe 
        35                  40                  45              

Gly Asp Glu Val Leu Leu Leu Ser Gly Ile His Gly Lys Ile Ile Ser 
    50                  55                  60                  

Ile Gln Asp Asp Leu Val Ser Leu Gln Ile Ala Lys Gly Val Val Ile 
65                  70                  75                  80  

His Val Glu Lys Glu Ser Val Met Gly Lys Thr Lys Glu Leu Leu Phe 
                85                  90                  95      

Lys 
    

<210>   483
<211>   1638
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   483
atgaaagaag aaagaagaca attttttgaa agagtcgatg gaaatcaatg tcgtgattat   60
atcttgtcgc actgttcaaa agactatgag aaagtcaaga gttcccttga acgcttgatg   120
gacaatcgtt ttatgtttga tagtccttgg gatatggagc cttgttcaaa aatccatcaa   180
atccagccga tggtatggga tcaagtattt gaagatgatc cagaatggtc ttatatgctc   240
aatcgacaag aatatctctt gcagtttatg atagggtatc tggtagaagg agataaggac   300
tatattcaaa agtgcaagtt ctttctattt gattggattg agcaggtgag agaattttct   360
cctcaatcct tgatgactag aaccttggat acgggtattc gttcctttac ttggttgaaa   420
ctactcttgc tcctcttgaa atttgacttg ctagaggaga aagaactaga gaaaattttg   480
gtcagtctag aaaagcagat tgactttatg aaaagctact atcgcgccaa gtacaccctt   540
agtaactggg ggattttaca aacaattccg atgcttgcta tctatcattt cttttcagat   600
aagatggatc tagaagaagc ttaccatttt gcttcagagg agttgaaaca gcaaattgag   660
acacagattt taggagatgg aagccagttt gaacagtcga ttctctatca tgtagaggtt   720
tataaagcct tgctggattt gtgtctcttg cttccagact tgcaagatag ttaccaagag   780
ttgctggaaa agatggcgac ctatattcaa atgatgacag gcttagatgg acggactttg   840
gcttttggtg atagcgattc tacagaaacg acagaaattt tgagcctgtc tgctgtggtt   900
ttgaaccagg aagaccttct taacggtctg gatgttaaag ttgatttgct tagcctcttg   960
ttcctggggc gagaaaaggt caagcgactg caggaatttg aaaagagagc ttggcagcct   1020
aagtccatga tctttgaaga ctctggacat gtctgcatta aggatgaaca tcgttatcta   1080
tttttcaaaa atggtccgct aggaagtgcc catagtcata gtgacgagaa tagtttttgc   1140
ttacagtatc aaggccaacc tattttcata gatgctgggc gttattctta tcgggagata   1200
tatgaacgtt atctcttaaa gagtgcttgg agtcattcga cctgcattgt agatgggaaa   1260
gctccggaaa gaatcacggg atcctgggaa tatgaatact atcctcactc cctgttttgt   1320
caccataaag aaagggaggg agtgcattat attgaggggg cttattggtc agcagaacct   1380
gatttgcctt atcttcacag gagaaaaatc ctcatgttgg tagaggatgt ctggctcttg   1440
gtagatgaca tcaggtgtca aggtcaacat gaggtgttga ctcagtttat ccttgacaag   1500
gatgtgacct atcaagatgg gaaaatcaat cagttgagac tatggagtga agttgatttt   1560
gatttggaag ataccatcat ttctcctaaa tccccaatta ttcaccccaa atctaaaaac   1620
catccagaat ccttgcct                                                 1638

<210>   484
<211>   546
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein, interruption
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902341 (0.E+01)

<400>   484
Met Lys Glu Glu Arg Arg Gln Phe Phe Glu Arg Val Asp Gly Asn Gln 
1               5                   10                  15      

Cys Arg Asp Tyr Ile Leu Ser His Cys Ser Lys Asp Tyr Glu Lys Val 
            20                  25                  30          

Lys Ser Ser Leu Glu Arg Leu Met Asp Asn Arg Phe Met Phe Asp Ser 
        35                  40                  45              

Pro Trp Asp Met Glu Pro Cys Ser Lys Ile His Gln Ile Gln Pro Met 
    50                  55                  60                  

Val Trp Asp Gln Val Phe Glu Asp Asp Pro Glu Trp Ser Tyr Met Leu 
65                  70                  75                  80  

Asn Arg Gln Glu Tyr Leu Leu Gln Phe Met Ile Gly Tyr Leu Val Glu 
                85                  90                  95      

Gly Asp Lys Asp Tyr Ile Gln Lys Cys Lys Phe Phe Leu Phe Asp Trp 
            100                 105                 110         

Ile Glu Gln Val Arg Glu Phe Ser Pro Gln Ser Leu Met Thr Arg Thr 
        115                 120                 125             

Leu Asp Thr Gly Ile Arg Ser Phe Thr Trp Leu Lys Leu Leu Leu Leu 
    130                 135                 140                 

Leu Leu Lys Phe Asp Leu Leu Glu Glu Lys Glu Leu Glu Lys Ile Leu 
145                 150                 155                 160 

Val Ser Leu Glu Lys Gln Ile Asp Phe Met Lys Ser Tyr Tyr Arg Ala 
                165                 170                 175     

Lys Tyr Thr Leu Ser Asn Trp Gly Ile Leu Gln Thr Ile Pro Met Leu 
            180                 185                 190         

Ala Ile Tyr His Phe Phe Ser Asp Lys Met Asp Leu Glu Glu Ala Tyr 
        195                 200                 205             

His Phe Ala Ser Glu Glu Leu Lys Gln Gln Ile Glu Thr Gln Ile Leu 
    210                 215                 220                 

Gly Asp Gly Ser Gln Phe Glu Gln Ser Ile Leu Tyr His Val Glu Val 
225                 230                 235                 240 

Tyr Lys Ala Leu Leu Asp Leu Cys Leu Leu Leu Pro Asp Leu Gln Asp 
                245                 250                 255     

Ser Tyr Gln Glu Leu Leu Glu Lys Met Ala Thr Tyr Ile Gln Met Met 
            260                 265                 270         

Thr Gly Leu Asp Gly Arg Thr Leu Ala Phe Gly Asp Ser Asp Ser Thr 
        275                 280                 285             

Glu Thr Thr Glu Ile Leu Ser Leu Ser Ala Val Val Leu Asn Gln Glu 
    290                 295                 300                 

Asp Leu Leu Asn Gly Leu Asp Val Lys Val Asp Leu Leu Ser Leu Leu 
305                 310                 315                 320 

Phe Leu Gly Arg Glu Lys Val Lys Arg Leu Gln Glu Phe Glu Lys Arg 
                325                 330                 335     

Ala Trp Gln Pro Lys Ser Met Ile Phe Glu Asp Ser Gly His Val Cys 
            340                 345                 350         

Ile Lys Asp Glu His Arg Tyr Leu Phe Phe Lys Asn Gly Pro Leu Gly 
        355                 360                 365             

Ser Ala His Ser His Ser Asp Glu Asn Ser Phe Cys Leu Gln Tyr Gln 
    370                 375                 380                 

Gly Gln Pro Ile Phe Ile Asp Ala Gly Arg Tyr Ser Tyr Arg Glu Ile 
385                 390                 395                 400 

Tyr Glu Arg Tyr Leu Leu Lys Ser Ala Trp Ser His Ser Thr Cys Ile 
                405                 410                 415     

Val Asp Gly Lys Ala Pro Glu Arg Ile Thr Gly Ser Trp Glu Tyr Glu 
            420                 425                 430         

Tyr Tyr Pro His Ser Leu Phe Cys His His Lys Glu Arg Glu Gly Val 
        435                 440                 445             

His Tyr Ile Glu Gly Ala Tyr Trp Ser Ala Glu Pro Asp Leu Pro Tyr 
    450                 455                 460                 

Leu His Arg Arg Lys Ile Leu Met Leu Val Glu Asp Val Trp Leu Leu 
465                 470                 475                 480 

Val Asp Asp Ile Arg Cys Gln Gly Gln His Glu Val Leu Thr Gln Phe 
                485                 490                 495     

Ile Leu Asp Lys Asp Val Thr Tyr Gln Asp Gly Lys Ile Asn Gln Leu 
            500                 505                 510         

Arg Leu Trp Ser Glu Val Asp Phe Asp Leu Glu Asp Thr Ile Ile Ser 
        515                 520                 525             

Pro Lys Ser Pro Ile Ile His Pro Lys Ser Lys Asn His Pro Glu Ser 
    530                 535                 540                 

Leu Pro 
545     

<210>   485
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   485
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattatt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg taggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   486
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   486
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      


Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   487
<211>   327
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   487
atgaatgatt tgggtaaata caatgagctt gaaagaagta gcaaactcac caagcgccaa   60
ttctttgaga atcagatgct ggattatacc atcattgcgc atgagagttt tgaaatcatc   120
cgtcattctg tctaccagac agatgatcgt gaagtggaaa atgctctggc ttttgaagtg   180
aaaaatgatg aaacagacaa gctgattctg ttattaagcg aggatattgg tgtaggtgaa   240
aaattgtgcc tcgttgacgg aacaaaaatg cgtggaaaat gtttagtata tgataaaata   300
aatgagagaa tgattcgctt gcagtgc                                       327

<210>   488
<211>   109
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein, interruption
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902341 (2.E-55)

<400>   488
Met Asn Asp Leu Gly Lys Tyr Asn Glu Leu Glu Arg Ser Ser Lys Leu 
1               5                   10                  15      

Thr Lys Arg Gln Phe Phe Glu Asn Gln Met Leu Asp Tyr Thr Ile Ile 
            20                  25                  30          

Ala His Glu Ser Phe Glu Ile Ile Arg His Ser Val Tyr Gln Thr Asp 
        35                  40                  45              

Asp Arg Glu Val Glu Asn Ala Leu Ala Phe Glu Val Lys Asn Asp Glu 
    50                  55                  60                  

Thr Asp Lys Leu Ile Leu Leu Leu Ser Glu Asp Ile Gly Val Gly Glu 
65                  70                  75                  80  

Lys Leu Cys Leu Val Asp Gly Thr Lys Met Arg Gly Lys Cys Leu Val 
                85                  90                  95      

Tyr Asp Lys Ile Asn Glu Arg Met Ile Arg Leu Gln Cys 
            100                 105                 

<210>   489
<211>   1065
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   489
gtgctagaaa taggcatttt gaatagtgaa tatgttataa taagtattag taggaggtgt   60
tttagattgg agaagaaact gaccataaaa gacattgcgg aaatggctca gacctcgaaa   120
acaaccgtgt cattttacct aaacgggaaa tatgaaaaaa tgtcccaaga gacacgtgaa   180
aagattgaaa aagttattca tgaaacaaat tacaaaccga gcattgttgc gcgtagctta   240
aactccaaac gaacaaaatt aatcggtgtt ttgattggtg atattaccaa cagtttctca   300
aaccaaattg ttaagggaat tgaggatatc gccagccaga atggctacca ggtaatgata   360
ggaaatagta attacagcca agagagtgag gaccggtata ttgaaagcat gcttctcttg   420
ggagtagacg gctttattat tcagccgacc tctaatttcc gaaaatattc tcgtatcatc   480
gatgagaaaa agaagaaaat ggtctttttt gatagtcagc tctatgaaca ccggactagc   540
tgggttaaaa ccaataacta tgatgccgtt tatgacatga cccagtcctg tatcgaaaaa   600
ggttatgaac attttctctt gattacagcg gatacgagtc gtttgagtac tcggattgag   660
cgggcaagtg gttttgtgga tgctttaaca gatgctaata tgcgtcacgc cagtctaacc   720
attgaagata agcatacgaa tttggaacaa attaaggaat ttttacaaaa agaaatcgat   780
cccgatgaaa aaactctggt atttatccct aactgttggg ccctacctct agtctttacc   840
gttatcaaag agttgaatta taacttgcca caagttgggt tgattggttt tgacaatacg   900
gagtggactt gcttttcttc tccaagtgtt tcgacgctgg ttcagccctc ctttgaggaa   960
ggacaacagg ctacaaagat tttgattgac cagattgaag gtcgcaatca agaagaaagg   1020
caacaagtct tggattgtag tgtgaattgg aaagagtcga ctttc                   1065

<210>   490
<211>   355
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar binding transcriptional regulator RegR (regR)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902342 (0.E+01)

<400>   490
Met Leu Glu Ile Gly Ile Leu Asn Ser Glu Tyr Val Ile Ile Ser Ile 
1               5                   10                  15      

Ser Arg Arg Cys Phe Arg Leu Glu Lys Lys Leu Thr Ile Lys Asp Ile 
            20                  25                  30          

Ala Glu Met Ala Gln Thr Ser Lys Thr Thr Val Ser Phe Tyr Leu Asn 
        35                  40                  45              

Gly Lys Tyr Glu Lys Met Ser Gln Glu Thr Arg Glu Lys Ile Glu Lys 
    50                  55                  60                  

Val Ile His Glu Thr Asn Tyr Lys Pro Ser Ile Val Ala Arg Ser Leu 
65                  70                  75                  80  

Asn Ser Lys Arg Thr Lys Leu Ile Gly Val Leu Ile Gly Asp Ile Thr 
                85                  90                  95      

Asn Ser Phe Ser Asn Gln Ile Val Lys Gly Ile Glu Asp Ile Ala Ser 
            100                 105                 110         

Gln Asn Gly Tyr Gln Val Met Ile Gly Asn Ser Asn Tyr Ser Gln Glu 
        115                 120                 125             


Ser Glu Asp Arg Tyr Ile Glu Ser Met Leu Leu Leu Gly Val Asp Gly 
    130                 135                 140                 

Phe Ile Ile Gln Pro Thr Ser Asn Phe Arg Lys Tyr Ser Arg Ile Ile 
145                 150                 155                 160 

Asp Glu Lys Lys Lys Lys Met Val Phe Phe Asp Ser Gln Leu Tyr Glu 
                165                 170                 175     

His Arg Thr Ser Trp Val Lys Thr Asn Asn Tyr Asp Ala Val Tyr Asp 
            180                 185                 190         

Met Thr Gln Ser Cys Ile Glu Lys Gly Tyr Glu His Phe Leu Leu Ile 
        195                 200                 205             

Thr Ala Asp Thr Ser Arg Leu Ser Thr Arg Ile Glu Arg Ala Ser Gly 
    210                 215                 220                 

Phe Val Asp Ala Leu Thr Asp Ala Asn Met Arg His Ala Ser Leu Thr 
225                 230                 235                 240 

Ile Glu Asp Lys His Thr Asn Leu Glu Gln Ile Lys Glu Phe Leu Gln 
                245                 250                 255     

Lys Glu Ile Asp Pro Asp Glu Lys Thr Leu Val Phe Ile Pro Asn Cys 
            260                 265                 270         

Trp Ala Leu Pro Leu Val Phe Thr Val Ile Lys Glu Leu Asn Tyr Asn 
        275                 280                 285             

Leu Pro Gln Val Gly Leu Ile Gly Phe Asp Asn Thr Glu Trp Thr Cys 
    290                 295                 300                 

Phe Ser Ser Pro Ser Val Ser Thr Leu Val Gln Pro Ser Phe Glu Glu 
305                 310                 315                 320 

Gly Gln Gln Ala Thr Lys Ile Leu Ile Asp Gln Ile Glu Gly Arg Asn 
                325                 330                 335     

Gln Glu Glu Arg Gln Gln Val Leu Asp Cys Ser Val Asn Trp Lys Glu 
            340                 345                 350         

Ser Thr Phe 
        355 

<210>   491
<211>   372
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   491
ttgcaagagc taaaaaagac caggattagg aggtgcctta tgaaatcact agctagacta   60
ctgatcattc atgtttttat cagtattttc cttttcttcg cccttacttc aggagctatt   120
tctcatacag ttttactact cctactcctc tttcttcctg cgctcaataa aggacttgag   180
aaaatacaat caaaacggat acctgtcctc aacgcagccc tcttctttct cctcatatcc   240
tttccacaac ttttaaccaa ccctgtccaa tggaaatttt caatattcct agtcgtaacc   300
atcatttcaa gtttggccta cttctataac ttttatcaag tagttaaaga agtagatcaa   360
aaacagttga tt                                                       372

<210>   492
<211>   124
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   492
Met Gln Glu Leu Lys Lys Thr Arg Ile Arg Arg Cys Leu Met Lys Ser 
1               5                   10                  15      

Leu Ala Arg Leu Leu Ile Ile His Val Phe Ile Ser Ile Phe Leu Phe 
            20                  25                  30          

Phe Ala Leu Thr Ser Gly Ala Ile Ser His Thr Val Leu Leu Leu Leu 
        35                  40                  45              

Leu Leu Phe Leu Pro Ala Leu Asn Lys Gly Leu Glu Lys Ile Gln Ser 
    50                  55                  60                  

Lys Arg Ile Pro Val Leu Asn Ala Ala Leu Phe Phe Leu Leu Ile Ser 
65                  70                  75                  80  

Phe Pro Gln Leu Leu Thr Asn Pro Val Gln Trp Lys Phe Ser Ile Phe 
                85                  90                  95      

Leu Val Val Thr Ile Ile Ser Ser Leu Ala Tyr Phe Tyr Asn Phe Tyr 
            100                 105                 110         

Gln Val Val Lys Glu Val Asp Gln Lys Gln Leu Ile 
        115                 120                 

<210>   493
<211>   261
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   493
atgaggatta ggaggaaact catgaaaaaa gaaaagaaac agttacgtta tcctggtctg   60
aaagcaggtt cgatttatgg aacagtgata ttttttataa ttccactcat tgatacccta   120
acaagtgaaa atccaaattt tatcagttct cttctaaata caaaacatat ttttaaaact   180
atactgggag ctttcttttt cggagtgatg atacatattg tcgactcact tcgtattgca   240
agagctaaaa aagaccagga t                                             261

<210>   494
<211>   87
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein, FRAMESHIFT

<400>   494
Met Arg Ile Arg Arg Lys Leu Met Lys Lys Glu Lys Lys Gln Leu Arg 
1               5                   10                  15      

Tyr Pro Gly Leu Lys Ala Gly Ser Ile Tyr Gly Thr Val Ile Phe Phe 
            20                  25                  30          

Ile Ile Pro Leu Ile Asp Thr Leu Thr Ser Glu Asn Pro Asn Phe Ile 
        35                  40                  45              

Ser Ser Leu Leu Asn Thr Lys His Ile Phe Lys Thr Ile Leu Gly Ala 
    50                  55                  60                  

Phe Phe Phe Gly Val Met Ile His Ile Val Asp Ser Leu Arg Ile Ala 
65                  70                  75                  80  

Arg Ala Lys Lys Asp Gln Asp 
                85          

<210>   495
<211>   540
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   495
atgaaaaaag aaaccttcac tgaaaaactg atcaaacgca catacggtat ttctggtccc   60
cttgacgaat acaaacggcg tgaggccgat agtattggga accaagtctt tatcatcctc   120
ttttatctga tgattttcgg aaatcttatt ccactccttc tggcctataa ataccctcaa   180
gaagtggctc taatctatcc tcctctgatt ttagtgattg ccctcatcgc ttctggctat   240

gtcacctacc aaatgaaaaa aacaggcatc acagtcattg aaccagatat gctgaatgag   300
aaagaaagca agcaactaca ctacccaggt ctgaaagcag gtttgttctt tggtctatgg   360
atgtttttta taactcctct tctcaggata ctcatagatg aaggtcagga ctattttcat   420
tctcttctca ctataagaaa tggtgtatca agtattctcg gttctatttt cttcggagcg   480
agcatacagt tcctcatctc ccgtcgcatt gcaaaaacta agaaaaatca agatgaggat   540

<210>   496
<211>   180
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902344 (8.E-16)

<400>   496
Met Lys Lys Glu Thr Phe Thr Glu Lys Leu Ile Lys Arg Thr Tyr Gly 
1               5                   10                  15      

Ile Ser Gly Pro Leu Asp Glu Tyr Lys Arg Arg Glu Ala Asp Ser Ile 
            20                  25                  30          

Gly Asn Gln Val Phe Ile Ile Leu Phe Tyr Leu Met Ile Phe Gly Asn 
        35                  40                  45              

Leu Ile Pro Leu Leu Leu Ala Tyr Lys Tyr Pro Gln Glu Val Ala Leu 
    50                  55                  60                  

Ile Tyr Pro Pro Leu Ile Leu Val Ile Ala Leu Ile Ala Ser Gly Tyr 
65                  70                  75                  80  

Val Thr Tyr Gln Met Lys Lys Thr Gly Ile Thr Val Ile Glu Pro Asp 
                85                  90                  95      

Met Leu Asn Glu Lys Glu Ser Lys Gln Leu His Tyr Pro Gly Leu Lys 
            100                 105                 110         

Ala Gly Leu Phe Phe Gly Leu Trp Met Phe Phe Ile Thr Pro Leu Leu 
        115                 120                 125             

Arg Ile Leu Ile Asp Glu Gly Gln Asp Tyr Phe His Ser Leu Leu Thr 
    130                 135                 140                 

Ile Arg Asn Gly Val Ser Ser Ile Leu Gly Ser Ile Phe Phe Gly Ala 
145                 150                 155                 160 

Ser Ile Gln Phe Leu Ile Ser Arg Arg Ile Ala Lys Thr Lys Lys Asn 
                165                 170                 175     

Gln Asp Glu Asp 
            180 

<210>   497
<211>   192
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   497
atgaatcgtg tgaaagaatt tcgcaaggaa ttgggtattt cccagctcga actcgccaag   60
gatatcggtg tctcgagaca gactatcaat atgattgaaa acgacaagta caatccaacc   120
ttggaactct gtctcaatct cgcccgcagc ctccaaactg acctcaacag tctcttttgg   180
gaggaagatt tt                                                       192

<210>   498
<211>   64
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902345 (7.E-33)

<400>   498
Met Asn Arg Val Lys Glu Phe Arg Lys Glu Leu Gly Ile Ser Gln Leu 
1               5                   10                  15      

Glu Leu Ala Lys Asp Ile Gly Val Ser Arg Gln Thr Ile Asn Met Ile 
            20                  25                  30          

Glu Asn Asp Lys Tyr Asn Pro Thr Leu Glu Leu Cys Leu Asn Leu Ala 
        35                  40                  45              

Arg Ser Leu Gln Thr Asp Leu Asn Ser Leu Phe Trp Glu Glu Asp Phe 
    50                  55                  60                  


<210>   499
<211>   948
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   499
atgacaaaag aatttcatca tgtaacggtc ttactccacg aaacgattga tatgcttgac   60
gtaaagcctg atggtatcta cgttgatgcg actttgggcg gagcaggaca tagcgagtat   120
ttattaagta aattaagtga aaaaggccat ctctatgcct ttgaccagga tcagaatgcc   180
attgacaatg cgcaaaaacg cttggcacct tacattgaga agggaatggt gacctttatc   240
aaggacaact tccgtcattt acaggcatgt ttgcgcgaag ctggtgttca ggaaattgat   300
ggaatttgtt atgacttggg agtgtctagt cctcaattag accagcgtga gcgtggtttt   360
tcttataaaa aggatgcgcc actggacatg cggatgaatc aggatgctag cctgacagcc   420
tatgaagtgg tgaacaatta tgactatcat gacttggttc gtattttctt caagtatgga   480
gaggacaaat tctctaaaca gattgcgcgt aagattgagc aagcgcgtga agtgaagccg   540
attgagacaa cgactgagtt agcagagatt atcaagttgg tcaaacctgc caaggaactc   600
aagaagaagg ggcatcctgc taagcagatt ttccaggcta ttcgaattga agtcaatgat   660
gaactgggag cggcagatga gtccatccag caggctatgg atatgttggc tctggatggt   720
agaatttcag tgattacctt tcattcctta gaagaccgct tgaccaagca attgttcaag   780
gaagcttcaa cagttgaagt tccaaaaggc ttgcctttca tcccagatga tctcaagccc   840
aagatggaat tggtgtcccg taagccaatc ttgccaagtg cggaagagtt agaagccaat   900
aaccgctcgc actcagccaa gttgcgcgtg gtcagaaaaa ttcacaag                948

<210>   500
<211>   316
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   yllC protein (yllC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902346 (e-178)

<400>   500
Met Thr Lys Glu Phe His His Val Thr Val Leu Leu His Glu Thr Ile 
1               5                   10                  15      

Asp Met Leu Asp Val Lys Pro Asp Gly Ile Tyr Val Asp Ala Thr Leu 
            20                  25                  30          

Gly Gly Ala Gly His Ser Glu Tyr Leu Leu Ser Lys Leu Ser Glu Lys 
        35                  40                  45              

Gly His Leu Tyr Ala Phe Asp Gln Asp Gln Asn Ala Ile Asp Asn Ala 
    50                  55                  60                  

Gln Lys Arg Leu Ala Pro Tyr Ile Glu Lys Gly Met Val Thr Phe Ile 
65                  70                  75                  80  

Lys Asp Asn Phe Arg His Leu Gln Ala Cys Leu Arg Glu Ala Gly Val 
                85                  90                  95      

Gln Glu Ile Asp Gly Ile Cys Tyr Asp Leu Gly Val Ser Ser Pro Gln 
            100                 105                 110         

Leu Asp Gln Arg Glu Arg Gly Phe Ser Tyr Lys Lys Asp Ala Pro Leu 
        115                 120                 125             

Asp Met Arg Met Asn Gln Asp Ala Ser Leu Thr Ala Tyr Glu Val Val 
    130                 135                 140                 

Asn Asn Tyr Asp Tyr His Asp Leu Val Arg Ile Phe Phe Lys Tyr Gly 
145                 150                 155                 160 

Glu Asp Lys Phe Ser Lys Gln Ile Ala Arg Lys Ile Glu Gln Ala Arg 
                165                 170                 175     

Glu Val Lys Pro Ile Glu Thr Thr Thr Glu Leu Ala Glu Ile Ile Lys 
            180                 185                 190         

Leu Val Lys Pro Ala Lys Glu Leu Lys Lys Lys Gly His Pro Ala Lys 
        195                 200                 205             

Gln Ile Phe Gln Ala Ile Arg Ile Glu Val Asn Asp Glu Leu Gly Ala 
    210                 215                 220                 

Ala Asp Glu Ser Ile Gln Gln Ala Met Asp Met Leu Ala Leu Asp Gly 
225                 230                 235                 240 

Arg Ile Ser Val Ile Thr Phe His Ser Leu Glu Asp Arg Leu Thr Lys 
                245                 250                 255     

Gln Leu Phe Lys Glu Ala Ser Thr Val Glu Val Pro Lys Gly Leu Pro 
            260                 265                 270         

Phe Ile Pro Asp Asp Leu Lys Pro Lys Met Glu Leu Val Ser Arg Lys 
        275                 280                 285             

Pro Ile Leu Pro Ser Ala Glu Glu Leu Glu Ala Asn Asn Arg Ser His 
    290                 295                 300                 

Ser Ala Lys Leu Arg Val Val Arg Lys Ile His Lys 
305                 310                 315     

<210>   501
<211>   315
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   501
atggcagaaa aaatggaaaa aacaggtcaa atactacaga tgcaacttaa acggttttcg   60
cgtgtggaaa aagcttttta cttttccatt gctgtaacca ctcttattgt agccattagt   120
attattttta tgcagaccaa gctcttgcaa gtgcagaatg atttgacaaa aatcaatgcg   180
cagatagagg aaaagaagac cgaattggac gatgccaagc aagaggtcaa tgaactatta   240
cgtgcagaac gtttgaaaga aattgccaat tcacacgatt tgcaattaaa caatgaaaat   300
attagaatag cggag                                                    315

<210>   502
<211>   105
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell division protein FtsL (ftsL)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902347 (3.E-53)

<400>   502
Met Ala Glu Lys Met Glu Lys Thr Gly Gln Ile Leu Gln Met Gln Leu 
1               5                   10                  15      

Lys Arg Phe Ser Arg Val Glu Lys Ala Phe Tyr Phe Ser Ile Ala Val 
            20                  25                  30          

Thr Thr Leu Ile Val Ala Ile Ser Ile Ile Phe Met Gln Thr Lys Leu 
        35                  40                  45              

Leu Gln Val Gln Asn Asp Leu Thr Lys Ile Asn Ala Gln Ile Glu Glu 
    50                  55                  60                  

Lys Lys Thr Glu Leu Asp Asp Ala Lys Gln Glu Val Asn Glu Leu Leu 
65                  70                  75                  80  

Arg Ala Glu Arg Leu Lys Glu Ile Ala Asn Ser His Asp Leu Gln Leu 
                85                  90                  95      

Asn Asn Glu Asn Ile Arg Ile Ala Glu 
            100                 105 

<210>   503
<211>   2250
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   503
atgaagtgga caaaaagagt aatccgttat gcgaccaaaa atcggaaatc gccggctgaa   60
aacagacgca gagttggaaa aagtctgagt ttattatctg tctttgtttt tgccattttt   120
ttagtcaatt ttgcggtcat tattgggaca ggcactcgct ttggaacaga tttagcgaag   180
gaagctaaga aggttcatca aaccacccgt acagttcctg ccaaacgtgg gactatttat   240
gaccgaaatg gagtcccgat tgctgaggat gcaacctcct ataatgtcta tgcggtcatt   300
gatgagaact ataagtcagc aacgggtaag attctttacg tagaaaaaac acaatttaac   360
aaggttgcag aggtctttca taagtatctg gacatggaag aatcctatgt aagagagcaa   420
ctctcgcaac ctaatctcaa gcaagtttcc tttggagcaa agggaaatgg gattacctat   480
gccaatatga tgtctatcaa aaaagaattg gaagctgcag aggtcaaggg gattgatttt   540
acaaccagtc ccaatcgtag ttacccaaac ggacaatttg cttctagttt tatcggtcta   600
gctcagctcc atgaaaatga agatggaagc aagagcttgc tgggaacctc tggaatggag   660
agttccttga acagtattct tgcagggaca gacggcatta ttacctatga aaaggatcgt   720
ctgggtaata ttgtacccgg aacagaacaa gtttcccaac gaacgatgga cggtaaggat   780
gtttatacaa ccatttccag ccccctccag tcctttatgg aaacccagat ggatgctttt   840
caagagaagg taaaaggaaa gtacatgaca gcgactttgg tcagtgctaa aacaggggaa   900
attctggcaa caacgcaacg accgaccttt gatgcagata caaaagaagg cattacagag   960
gactttgttt ggcgtgatat cctttaccaa agtaactatg agccaggttc cactatgaaa   1020
gtgatgatgt tggctgctgc tattgataat aatacctttc caggaggaga agtctttaat   1080
agtagtgagt taaaaattgc agatgccacg attcgagatt gggacgttaa tgaaggattg   1140
actggtggca gaacgatgac tttttctcaa ggttttgcac actcaagtaa cgttgggatg   1200
accctccttg agcaaaagat gggagatgct acctggcttg attatcttaa tcgttttaaa   1260
tttggagttc cgacccgttt cggtttgacg gatgagtatg ctggtcagct tcctgcggat   1320
aatattgtca acattgcgca aagctcattt ggacaaggga tttcagtgac ccagacgcaa   1380
atgattcgtg cctttacagc tattgctaat gacggtgtca tgctggagcc taaatttatt   1440
agtgccattt atgatccaaa tgatcaaact gctcggaaat ctcaaaaaga aattgtggga   1500
aatcctgttt ctaaagatgc agctagtcta actcggacta acatggtttt ggtagggacg   1560
gatccggttt atggaaccat gtataaccac agcacaggca agccaactgt aactgttcct   1620
gggcaaaatg tagccctcaa gtctggtacg gctcagattg ctgacgagaa aaatggtggt   1680
tatctagtcg ggttaaccga ctatattttc tcggctgtat cgatgagtcc ggctgaaaat   1740
cctgatttta tcttgtatgt gacggtccaa caacctgaac attattcagg tattcagttg   1800
ggagaatttg ccaatcctat cttggagcgg gcttcagcta tgaaagactc tctcaatctt   1860
caaacaacag ctaaggcttt agagcaagta agtcaacaaa gtccttatcc tatgcctagt   1920
gtcaaggata tttcacctgg tgatttagca gaagaattgc gtcgcaatct tgtacaaccc   1980
atcgttgtgg gaacaggaac gaagattaaa aacagttctg ctgaagaagg gaagaatctt   2040
gccccgaacc agcaagtcct tatcttatct gataaagcag aggaggttcc agatatgtat   2100
ggttggacaa aggagactgc tgagaccctt gctaagtggc tcaatataga acttgaattt   2160
caaggttcgg gctctactgt gcagaagcaa gatgttcgtg ctaacacagc tatcaaggac   2220
attaaaaaaa ttacattaac tttaggagac                                    2250

<210>   504
<211>   750
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   penicillin-binding protein 2X (pbpX)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902348 (0.E+01)

<400>   504
Met Lys Trp Thr Lys Arg Val Ile Arg Tyr Ala Thr Lys Asn Arg Lys 
1               5                   10                  15      

Ser Pro Ala Glu Asn Arg Arg Arg Val Gly Lys Ser Leu Ser Leu Leu 
            20                  25                  30          

Ser Val Phe Val Phe Ala Ile Phe Leu Val Asn Phe Ala Val Ile Ile 
        35                  40                  45              

Gly Thr Gly Thr Arg Phe Gly Thr Asp Leu Ala Lys Glu Ala Lys Lys 
    50                  55                  60                  

Val His Gln Thr Thr Arg Thr Val Pro Ala Lys Arg Gly Thr Ile Tyr 
65                  70                  75                  80  

Asp Arg Asn Gly Val Pro Ile Ala Glu Asp Ala Thr Ser Tyr Asn Val 
                85                  90                  95      

Tyr Ala Val Ile Asp Glu Asn Tyr Lys Ser Ala Thr Gly Lys Ile Leu 
            100                 105                 110         

Tyr Val Glu Lys Thr Gln Phe Asn Lys Val Ala Glu Val Phe His Lys 
        115                 120                 125             

Tyr Leu Asp Met Glu Glu Ser Tyr Val Arg Glu Gln Leu Ser Gln Pro 
    130                 135                 140                 

Asn Leu Lys Gln Val Ser Phe Gly Ala Lys Gly Asn Gly Ile Thr Tyr 
145                 150                 155                 160 

Ala Asn Met Met Ser Ile Lys Lys Glu Leu Glu Ala Ala Glu Val Lys 
                165                 170                 175     

Gly Ile Asp Phe Thr Thr Ser Pro Asn Arg Ser Tyr Pro Asn Gly Gln 
            180                 185                 190         

Phe Ala Ser Ser Phe Ile Gly Leu Ala Gln Leu His Glu Asn Glu Asp 
        195                 200                 205             

Gly Ser Lys Ser Leu Leu Gly Thr Ser Gly Met Glu Ser Ser Leu Asn 
    210                 215                 220                 

Ser Ile Leu Ala Gly Thr Asp Gly Ile Ile Thr Tyr Glu Lys Asp Arg 
225                 230                 235                 240 

Leu Gly Asn Ile Val Pro Gly Thr Glu Gln Val Ser Gln Arg Thr Met 
                245                 250                 255     

Asp Gly Lys Asp Val Tyr Thr Thr Ile Ser Ser Pro Leu Gln Ser Phe 
            260                 265                 270         

Met Glu Thr Gln Met Asp Ala Phe Gln Glu Lys Val Lys Gly Lys Tyr 
        275                 280                 285             

Met Thr Ala Thr Leu Val Ser Ala Lys Thr Gly Glu Ile Leu Ala Thr 
    290                 295                 300                 

Thr Gln Arg Pro Thr Phe Asp Ala Asp Thr Lys Glu Gly Ile Thr Glu 
305                 310                 315                 320 

Asp Phe Val Trp Arg Asp Ile Leu Tyr Gln Ser Asn Tyr Glu Pro Gly 
                325                 330                 335     

Ser Thr Met Lys Val Met Met Leu Ala Ala Ala Ile Asp Asn Asn Thr 
            340                 345                 350         

Phe Pro Gly Gly Glu Val Phe Asn Ser Ser Glu Leu Lys Ile Ala Asp 
        355                 360                 365             

Ala Thr Ile Arg Asp Trp Asp Val Asn Glu Gly Leu Thr Gly Gly Arg 
    370                 375                 380                 

Thr Met Thr Phe Ser Gln Gly Phe Ala His Ser Ser Asn Val Gly Met 
385                 390                 395                 400 

Thr Leu Leu Glu Gln Lys Met Gly Asp Ala Thr Trp Leu Asp Tyr Leu 
                405                 410                 415     

Asn Arg Phe Lys Phe Gly Val Pro Thr Arg Phe Gly Leu Thr Asp Glu 
            420                 425                 430         

Tyr Ala Gly Gln Leu Pro Ala Asp Asn Ile Val Asn Ile Ala Gln Ser 
        435                 440                 445             

Ser Phe Gly Gln Gly Ile Ser Val Thr Gln Thr Gln Met Ile Arg Ala 
    450                 455                 460                 

Phe Thr Ala Ile Ala Asn Asp Gly Val Met Leu Glu Pro Lys Phe Ile 
465                 470                 475                 480 

Ser Ala Ile Tyr Asp Pro Asn Asp Gln Thr Ala Arg Lys Ser Gln Lys 
                485                 490                 495     

Glu Ile Val Gly Asn Pro Val Ser Lys Asp Ala Ala Ser Leu Thr Arg 
            500                 505                 510         

Thr Asn Met Val Leu Val Gly Thr Asp Pro Val Tyr Gly Thr Met Tyr 
        515                 520                 525             

Asn His Ser Thr Gly Lys Pro Thr Val Thr Val Pro Gly Gln Asn Val 
    530                 535                 540                 

Ala Leu Lys Ser Gly Thr Ala Gln Ile Ala Asp Glu Lys Asn Gly Gly 
545                 550                 555                 560 

Tyr Leu Val Gly Leu Thr Asp Tyr Ile Phe Ser Ala Val Ser Met Ser 
                565                 570                 575     

Pro Ala Glu Asn Pro Asp Phe Ile Leu Tyr Val Thr Val Gln Gln Pro 
            580                 585                 590         

Glu His Tyr Ser Gly Ile Gln Leu Gly Glu Phe Ala Asn Pro Ile Leu 
        595                 600                 605             

Glu Arg Ala Ser Ala Met Lys Asp Ser Leu Asn Leu Gln Thr Thr Ala 
    610                 615                 620                 

Lys Ala Leu Glu Gln Val Ser Gln Gln Ser Pro Tyr Pro Met Pro Ser 
625                 630                 635                 640 

Val Lys Asp Ile Ser Pro Gly Asp Leu Ala Glu Glu Leu Arg Arg Asn 
                645                 650                 655     

Leu Val Gln Pro Ile Val Val Gly Thr Gly Thr Lys Ile Lys Asn Ser 
            660                 665                 670         

Ser Ala Glu Glu Gly Lys Asn Leu Ala Pro Asn Gln Gln Val Leu Ile 
        675                 680                 685             

Leu Ser Asp Lys Ala Glu Glu Val Pro Asp Met Tyr Gly Trp Thr Lys 
    690                 695                 700                 

Glu Thr Ala Glu Thr Leu Ala Lys Trp Leu Asn Ile Glu Leu Glu Phe 
705                 710                 715                 720 

Gln Gly Ser Gly Ser Thr Val Gln Lys Gln Asp Val Arg Ala Asn Thr 
                725                 730                 735     

Ala Ile Lys Asp Ile Lys Lys Ile Thr Leu Thr Leu Gly Asp 
            740                 745                 750 

<210>   505
<211>   978
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   505
atgtttattt ccatcagtgc tggaattgtg acatttttac taactttagt agaaattccg   60
gcctttatcc aattttatag aaaggcgcaa attacaggcc agcagatgca tgaggatgtc   120
aaacagcatc aggcaaaagc tgggactcct acaatgggag gtttggtttt cttgattact   180
tctgttttgg ttgctttctt tttcgcccta tttagtagcc aattcagcaa taatgtggga   240
atgattttgt tcatcttggt cttgtatggc ttggtcggat ttttagatga ctttctcaag   300
gtctttcgta aaatcaatga ggggcttaat cctaagcaaa aattagctct tcagcttcta   360
ggtggagtta tcttctatct tttctatgag cgcggtggcg atatcctgtc tgtctttggt   420
tatccagttc atttgggatt tttctatatt ttcttcgctc ttttctggct agtcggtttt   480
tcaaacgcag taaacttgac agacggtgtt gacggtttag ctagtatttc cgttgtgatt   540
agtttgtctg cctatggagt tattgcctat gtgcaaggtc agatggatat tcttctagtg   600
attcttgcca tgattggtgg tttgctcggt ttcttcatct ttaaccataa gcctgccaag   660
gtctttatgg gtgatgtggg aagtttggcc ctaggtggga tgctggcagc tatctctatg   720
gctctccacc aagaatggac tctcttgatt atcggaattg tgtatgtttt tgaaacaact   780
tctgttatga tgcaagtcag ttatttcaaa ctgacaggtg gtaaacgtat tttccgtatg   840
acgcctgtac atcaccattt tgagcttggg ggattgtctg gtaaaggaaa tccttggagc   900
gagtggaagg ttgacttctt cttttgggga gtgggacttc tagcaagtct cctgacccta   960
gcaattttat atttgatg                                                 978

<210>   506
<211>   326
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902349 (0.E+01)

<400>   506
Met Phe Ile Ser Ile Ser Ala Gly Ile Val Thr Phe Leu Leu Thr Leu 
1               5                   10                  15      

Val Glu Ile Pro Ala Phe Ile Gln Phe Tyr Arg Lys Ala Gln Ile Thr 
            20                  25                  30          

Gly Gln Gln Met His Glu Asp Val Lys Gln His Gln Ala Lys Ala Gly 
        35                  40                  45              

Thr Pro Thr Met Gly Gly Leu Val Phe Leu Ile Thr Ser Val Leu Val 
    50                  55                  60                  

Ala Phe Phe Phe Ala Leu Phe Ser Ser Gln Phe Ser Asn Asn Val Gly 
65                  70                  75                  80  

Met Ile Leu Phe Ile Leu Val Leu Tyr Gly Leu Val Gly Phe Leu Asp 
                85                  90                  95      

Asp Phe Leu Lys Val Phe Arg Lys Ile Asn Glu Gly Leu Asn Pro Lys 
            100                 105                 110         

Gln Lys Leu Ala Leu Gln Leu Leu Gly Gly Val Ile Phe Tyr Leu Phe 
        115                 120                 125             

Tyr Glu Arg Gly Gly Asp Ile Leu Ser Val Phe Gly Tyr Pro Val His 
    130                 135                 140                 

Leu Gly Phe Phe Tyr Ile Phe Phe Ala Leu Phe Trp Leu Val Gly Phe 
145                 150                 155                 160 

Ser Asn Ala Val Asn Leu Thr Asp Gly Val Asp Gly Leu Ala Ser Ile 
                165                 170                 175     

Ser Val Val Ile Ser Leu Ser Ala Tyr Gly Val Ile Ala Tyr Val Gln 
            180                 185                 190         

Gly Gln Met Asp Ile Leu Leu Val Ile Leu Ala Met Ile Gly Gly Leu 
        195                 200                 205             

Leu Gly Phe Phe Ile Phe Asn His Lys Pro Ala Lys Val Phe Met Gly 
    210                 215                 220                 

Asp Val Gly Ser Leu Ala Leu Gly Gly Met Leu Ala Ala Ile Ser Met 
225                 230                 235                 240 

Ala Leu His Gln Glu Trp Thr Leu Leu Ile Ile Gly Ile Val Tyr Val 
                245                 250                 255     

Phe Glu Thr Thr Ser Val Met Met Gln Val Ser Tyr Phe Lys Leu Thr 
            260                 265                 270         

Gly Gly Lys Arg Ile Phe Arg Met Thr Pro Val His His His Phe Glu 
        275                 280                 285             

Leu Gly Gly Leu Ser Gly Lys Gly Asn Pro Trp Ser Glu Trp Lys Val 
    290                 295                 300                 

Asp Phe Phe Phe Trp Gly Val Gly Leu Leu Ala Ser Leu Leu Thr Leu 
305                 310                 315                 320 

Ala Ile Leu Tyr Leu Met 
                325     

<210>   507
<211>   186
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   507

ttgttagaaa tcgatttgac tgtcctgatt gatttgtcct gttcttattt cgttttaata   60
tacagttttg agatggttga tagaactgac gaagtcagct caaaacacgg ttttgaggtt   120
gtagataagg agaagctgat gtggtttgaa gaggttttcg aagagtgtaa aaaaatattg   180
gtcagt                                                              186

<210>   508
<211>   62
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   508
Met Leu Glu Ile Asp Leu Thr Val Leu Ile Asp Leu Ser Cys Ser Tyr 
1               5                   10                  15      

Phe Val Leu Ile Tyr Ser Phe Glu Met Val Asp Arg Thr Asp Glu Val 
            20                  25                  30          

Ser Ser Lys His Gly Phe Glu Val Val Asp Lys Glu Lys Leu Met Trp 
        35                  40                  45              

Phe Glu Glu Val Phe Glu Glu Cys Lys Lys Ile Leu Val Ser 
    50                  55                  60          

<210>   509
<211>   2103
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   509
atgaataaca actttaataa ttttaataac atggatgatt tatttaacca attgatgggt   60
ggtatgcgag gatacagttc tgaaaatcgc cgttacttaa ttaatggacg cgaagtcaca   120
cctgaggaat ttgctcacta tcgtgcgact ggtcaattac caggaaatgc agaaactgat   180
gtgcaaatgc cacaacaggc atcaggtatg aaacaaggcg gtgtccttgc aaaactaggt   240
cgaaacttaa cagcagaagc gcgtgagggc aagttggatc ctgttatcgg acgaaacaag   300
gaaattcaag aaacatctga aatcctctca cgccgcacca agaacaatcc tgttttggtc   360
ggagatgcag gtgttggtaa gacagcagtt gtcgaaggtc tagcgcaagc cattgtgaac   420
ggagatgttc ctgctgctat caagaacaag gaaattattt ctattgatat ctcaggtctt   480
gaggctggta ctcaataccg tggtagcttt gaagaaaatg tccaaaactt agtcaatgaa   540
gtgaaagaag cagggaatat tatcctcttc tttgatgaaa ttcaccaaat tcttggtgct   600
ggtagcactg gtggagacag tggttctaaa ggacttgcgg atattctcaa gccagctctc   660
tctcgtggag aattgacagt gattggggca acaactcaag acgaataccg taacaccatc   720
ttgaagaatg ctgctcttgc tcgtcgtttc aacgaagtga aggtcaatgc tccttcggca   780
gagaatactt ttaaaattct tcaaggaatt cgtgacctct atcaacaaca ccacaatgtc   840
atcttgccag acgaagtctt gaaagcagcg gtggattatt ctgttcaata cattcctcaa   900
cgtagcttgc cagataaggc tattgacctt gtcgatgtaa cggctgctca cttggcggct   960
caacatccag taacagatgt gcatgctgtt gaacgagaaa tcgaaacgga aaaagacaag   1020
caagaaaaag cagttgaagc agaagatttt gaagcagctc taaactataa aacacgcatt   1080
gcagaattgg aaaggaaaat cgaaaaccac acagaagata tgaaagtgac tgcaagtgtc   1140
aacgatgtgg ctgaatctgt ggaacgaatg acaggtatcc cagtatcgca aatggaagct   1200
tcagatatcg aacgtttgaa agatatggct catcgcttgc aagacaaggt gattggtcaa   1260
gataaggccg tagaagttgt agctcgtgct atccgtcgta accgtgctgg ttttgatgaa   1320
ggaaatcgcc caatcggcaa cttcctcttt gtagggtcta ctggggttgg taagacggag   1380
cttgctaagc aattggcact cgatatgttt ggaacccagg atgcgattat ccgtttagat   1440
atgtctgaat acagtgaccg cacagctgtt tctaagctaa ttggtacaac agcaggctat   1500
gtgggttatg atgacaatag caatacctta acagaacgtg ttcgtcgcaa tccatactct   1560
atcattctct tggatgaaat tgaaaaggct gaccctcaag ttattaccct tctcctccaa   1620
gttctagatg atggtcgttt gacagatggt caaggaaata cagtaaactt caagaacact   1680
gtcattattg cgacctcaaa tgctggattt ggctatgaag ccaacttgac agaagatgcg   1740
gataaaccag aattgatgga ccgtttgaaa cccttcttcc gtccagaatt cctcaaccgc   1800
tttaatgcag tcatcgagtt ctcacacttg actaaggaag acctttctaa gattgtagat   1860
ttgatgttgg ctgaagttaa ccaaaccttg gctaagaaag acattgactt ggtagtcagt   1920
caagcggcta aagattatat cacagaagaa ggttacgacg aagtcatggg ggttcgtcct   1980
ctccgtcgcg tggttgaaca agaaattcgt gataaggtga cagacttcca cttggatcat   2040
ttagatgcta aacatctgga agcagatatg gaagatggcg ttttggttat tcgtgagaaa   2100
gtc                                                                 2103

<210>   510
<211>   701
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent Clp protease, ATP-binding subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902351 (0.E+01)

<400>   510
Met Asn Asn Asn Phe Asn Asn Phe Asn Asn Met Asp Asp Leu Phe Asn 
1               5                   10                  15      

Gln Leu Met Gly Gly Met Arg Gly Tyr Ser Ser Glu Asn Arg Arg Tyr 
            20                  25                  30          

Leu Ile Asn Gly Arg Glu Val Thr Pro Glu Glu Phe Ala His Tyr Arg 
        35                  40                  45              

Ala Thr Gly Gln Leu Pro Gly Asn Ala Glu Thr Asp Val Gln Met Pro 
    50                  55                  60                  

Gln Gln Ala Ser Gly Met Lys Gln Gly Gly Val Leu Ala Lys Leu Gly 
65                  70                  75                  80  

Arg Asn Leu Thr Ala Glu Ala Arg Glu Gly Lys Leu Asp Pro Val Ile 
                85                  90                  95      

Gly Arg Asn Lys Glu Ile Gln Glu Thr Ser Glu Ile Leu Ser Arg Arg 
            100                 105                 110         

Thr Lys Asn Asn Pro Val Leu Val Gly Asp Ala Gly Val Gly Lys Thr 
        115                 120                 125             

Ala Val Val Glu Gly Leu Ala Gln Ala Ile Val Asn Gly Asp Val Pro 
    130                 135                 140                 

Ala Ala Ile Lys Asn Lys Glu Ile Ile Ser Ile Asp Ile Ser Gly Leu 
145                 150                 155                 160 

Glu Ala Gly Thr Gln Tyr Arg Gly Ser Phe Glu Glu Asn Val Gln Asn 
                165                 170                 175     

Leu Val Asn Glu Val Lys Glu Ala Gly Asn Ile Ile Leu Phe Phe Asp 
            180                 185                 190         

Glu Ile His Gln Ile Leu Gly Ala Gly Ser Thr Gly Gly Asp Ser Gly 
        195                 200                 205             

Ser Lys Gly Leu Ala Asp Ile Leu Lys Pro Ala Leu Ser Arg Gly Glu 
    210                 215                 220                 

Leu Thr Val Ile Gly Ala Thr Thr Gln Asp Glu Tyr Arg Asn Thr Ile 
225                 230                 235                 240 

Leu Lys Asn Ala Ala Leu Ala Arg Arg Phe Asn Glu Val Lys Val Asn 
                245                 250                 255     

Ala Pro Ser Ala Glu Asn Thr Phe Lys Ile Leu Gln Gly Ile Arg Asp 
            260                 265                 270         

Leu Tyr Gln Gln His His Asn Val Ile Leu Pro Asp Glu Val Leu Lys 
        275                 280                 285             

Ala Ala Val Asp Tyr Ser Val Gln Tyr Ile Pro Gln Arg Ser Leu Pro 
    290                 295                 300                 

Asp Lys Ala Ile Asp Leu Val Asp Val Thr Ala Ala His Leu Ala Ala 
305                 310                 315                 320 

Gln His Pro Val Thr Asp Val His Ala Val Glu Arg Glu Ile Glu Thr 
                325                 330                 335     

Glu Lys Asp Lys Gln Glu Lys Ala Val Glu Ala Glu Asp Phe Glu Ala 
            340                 345                 350         

Ala Leu Asn Tyr Lys Thr Arg Ile Ala Glu Leu Glu Arg Lys Ile Glu 
        355                 360                 365             


Asn His Thr Glu Asp Met Lys Val Thr Ala Ser Val Asn Asp Val Ala 
    370                 375                 380                 

Glu Ser Val Glu Arg Met Thr Gly Ile Pro Val Ser Gln Met Glu Ala 
385                 390                 395                 400 

Ser Asp Ile Glu Arg Leu Lys Asp Met Ala His Arg Leu Gln Asp Lys 
                405                 410                 415     

Val Ile Gly Gln Asp Lys Ala Val Glu Val Val Ala Arg Ala Ile Arg 
            420                 425                 430         

Arg Asn Arg Ala Gly Phe Asp Glu Gly Asn Arg Pro Ile Gly Asn Phe 
        435                 440                 445             

Leu Phe Val Gly Ser Thr Gly Val Gly Lys Thr Glu Leu Ala Lys Gln 
    450                 455                 460                 

Leu Ala Leu Asp Met Phe Gly Thr Gln Asp Ala Ile Ile Arg Leu Asp 
465                 470                 475                 480 

Met Ser Glu Tyr Ser Asp Arg Thr Ala Val Ser Lys Leu Ile Gly Thr 
                485                 490                 495     

Thr Ala Gly Tyr Val Gly Tyr Asp Asp Asn Ser Asn Thr Leu Thr Glu 
            500                 505                 510         

Arg Val Arg Arg Asn Pro Tyr Ser Ile Ile Leu Leu Asp Glu Ile Glu 
        515                 520                 525             

Lys Ala Asp Pro Gln Val Ile Thr Leu Leu Leu Gln Val Leu Asp Asp 
    530                 535                 540                 

Gly Arg Leu Thr Asp Gly Gln Gly Asn Thr Val Asn Phe Lys Asn Thr 
545                 550                 555                 560 

Val Ile Ile Ala Thr Ser Asn Ala Gly Phe Gly Tyr Glu Ala Asn Leu 
                565                 570                 575     

Thr Glu Asp Ala Asp Lys Pro Glu Leu Met Asp Arg Leu Lys Pro Phe 
            580                 585                 590         

Phe Arg Pro Glu Phe Leu Asn Arg Phe Asn Ala Val Ile Glu Phe Ser 
        595                 600                 605             

His Leu Thr Lys Glu Asp Leu Ser Lys Ile Val Asp Leu Met Leu Ala 
    610                 615                 620                 

Glu Val Asn Gln Thr Leu Ala Lys Lys Asp Ile Asp Leu Val Val Ser 
625                 630                 635                 640 

Gln Ala Ala Lys Asp Tyr Ile Thr Glu Glu Gly Tyr Asp Glu Val Met 
                645                 650                 655     

Gly Val Arg Pro Leu Arg Arg Val Val Glu Gln Glu Ile Arg Asp Lys 
            660                 665                 670         

Val Thr Asp Phe His Leu Asp His Leu Asp Ala Lys His Leu Glu Ala 
        675                 680                 685             

Asp Met Glu Asp Gly Val Leu Val Ile Arg Glu Lys Val 
    690                 695                 700     

<210>   511
<211>   480
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   511
atgtcaaaag aagttattgt cgaaagtttt gaacttgacc acaccattgt caaagcaccc   60
tatgttcgct tgattgggga agaaacagga ccaaaaggag acatcatctc caattatgat   120
attcgcttgg tgcaaccaaa cgaagactct atccctactg ccggccttca cactatcgag   180
cacctcttag ccaaactcat ccgtacccgc attgacggca tgattgactg ttcaccattt   240
ggttgccgca caggcttcca catgattatg tggggacgtc acaccagtgc taaaatcgca   300
gctgttatca aggattcgct caaggaaatc gctgaaacta ctacttggga agatgtccca   360
gggacaacca tcgaatcttg cggaaactac aaggaccaca gcctcttctc tgctaaagaa   420
tgggcaaaac tcatcttgga acaagggatt tcagatgatg cctttgaacg tcatgtgatt   480

<210>   512
<211>   160
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   autoinducer-2 production protein (luxS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902352 (1.E-91)

<400>   512
Met Ser Lys Glu Val Ile Val Glu Ser Phe Glu Leu Asp His Thr Ile 
1               5                   10                  15      

Val Lys Ala Pro Tyr Val Arg Leu Ile Gly Glu Glu Thr Gly Pro Lys 
            20                  25                  30          

Gly Asp Ile Ile Ser Asn Tyr Asp Ile Arg Leu Val Gln Pro Asn Glu 
        35                  40                  45              

Asp Ser Ile Pro Thr Ala Gly Leu His Thr Ile Glu His Leu Leu Ala 
    50                  55                  60                  

Lys Leu Ile Arg Thr Arg Ile Asp Gly Met Ile Asp Cys Ser Pro Phe 
65                  70                  75                  80  

Gly Cys Arg Thr Gly Phe His Met Ile Met Trp Gly Arg His Thr Ser 
                85                  90                  95      

Ala Lys Ile Ala Ala Val Ile Lys Asp Ser Leu Lys Glu Ile Ala Glu 
            100                 105                 110         

Thr Thr Thr Trp Glu Asp Val Pro Gly Thr Thr Ile Glu Ser Cys Gly 
        115                 120                 125             

Asn Tyr Lys Asp His Ser Leu Phe Ser Ala Lys Glu Trp Ala Lys Leu 
    130                 135                 140                 

Ile Leu Glu Gln Gly Ile Ser Asp Asp Ala Phe Glu Arg His Val Ile 
145                 150                 155                 160 


<210>   513
<211>   1482
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   513
atgaaaaaac aagcttttag ttctgaacaa tatttgaatt tacaacgcga ccatattttg   60
gagcgcatta accaatttga cggcaagctc tacttagagt ttggcggtaa aatgttagaa   120
gatttccacg ctgctcgtgt ccttcctggt tatgaacctg acaacaaaat caagctcttg   180
caagaattga aagagcaggt tgaggttgtg attgccatta atgctagcaa cattgaacat   240
tccaaagcac gtggcgactt aggcatttct tatgaccaag aagttcttcg tttgattgat   300
aaattcaatg aattagggat ttttgttggt tccgttgtca ttacacaata cgctggccaa   360
cccgctgcag atgccttccg caatcaactt gagaaaaacg gaattgattc ttatcttcat   420
tatccaatca aaggatatcc gacggatatg gatcacatca tttccccaga aggcatgggc   480
aaaaacgact acatcaaaac cagtcgcaac ttgattgtcg taaccgctcc tggacctggt   540
tctggaaaat tggcaacgtg tatgtccaat atgtaccacg accaaatcaa tggcatcaaa   600
tctggctacg ctaaatttga aaccttccct gtttggaatc ttccccttca tcatccagtt   660
aacttggctt atgaagctgc cacagctgac cttgatgatg tcaacatgat tgaccccttc   720
catcttcaaa cctatggaga aaccactgtc aactacaacc gtgatatcga aatcttccca   780
gtgctcaaac gcatgttgga acgtattctc ggaaaatcac catacgcttc accgacagat   840
atgggtgtca acatggttgg tttcgctatt acagatgacg aggccgctgt cgaagcttct   900
aaacaagaaa tcatccgccg ttactatcaa acagttcttg acttcaaagc tgaaaaagtt   960
ggcgaagctg ccgtcaagaa aattgagttg ctcatgaacg acctcggtat cacacctgca   1020
gaccgtaagg ttgctgtcgt tgcgcgccaa aaagcagaag aaactggtgg accagcccta   1080
gcctttgaat tgccaaatgg ggaaatcatc actggtaaga actcagaact ctttggtcct   1140
acagccgctg ccttgatcaa cgccatcaaa aaatcagctg acatcgctaa agaagtaaaa   1200
ctaatcgagc ctgaagttgt taagccaatc caaggtctta aaatcgatca tctcggtagc   1260
cgcaatccac gccttcattc aaatgaaatc ctgattgcac ttgctatcac agctacagaa   1320
aatcctgatg ctgcccgcgc tatggaagaa ctcggcaacc tcaaaggaag cgaagcccac   1380
tcaaccatca tcttgactga tgaagacaag aatgtccttc gtaaactggg tatcaacgta   1440
acctttgacc catactacca atacgaccgc ttatatcgta ag                      1482

<210>   514
<211>   494
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15902353 (0.E+01)

<400>   514
Met Lys Lys Gln Ala Phe Ser Ser Glu Gln Tyr Leu Asn Leu Gln Arg 
1               5                   10                  15      

Asp His Ile Leu Glu Arg Ile Asn Gln Phe Asp Gly Lys Leu Tyr Leu 
            20                  25                  30          

Glu Phe Gly Gly Lys Met Leu Glu Asp Phe His Ala Ala Arg Val Leu 
        35                  40                  45              

Pro Gly Tyr Glu Pro Asp Asn Lys Ile Lys Leu Leu Gln Glu Leu Lys 
    50                  55                  60                  

Glu Gln Val Glu Val Val Ile Ala Ile Asn Ala Ser Asn Ile Glu His 
65                  70                  75                  80  

Ser Lys Ala Arg Gly Asp Leu Gly Ile Ser Tyr Asp Gln Glu Val Leu 
                85                  90                  95      

Arg Leu Ile Asp Lys Phe Asn Glu Leu Gly Ile Phe Val Gly Ser Val 
            100                 105                 110         

Val Ile Thr Gln Tyr Ala Gly Gln Pro Ala Ala Asp Ala Phe Arg Asn 
        115                 120                 125             

Gln Leu Glu Lys Asn Gly Ile Asp Ser Tyr Leu His Tyr Pro Ile Lys 
    130                 135                 140                 

Gly Tyr Pro Thr Asp Met Asp His Ile Ile Ser Pro Glu Gly Met Gly 
145                 150                 155                 160 

Lys Asn Asp Tyr Ile Lys Thr Ser Arg Asn Leu Ile Val Val Thr Ala 
                165                 170                 175     

Pro Gly Pro Gly Ser Gly Lys Leu Ala Thr Cys Met Ser Asn Met Tyr 
            180                 185                 190         

His Asp Gln Ile Asn Gly Ile Lys Ser Gly Tyr Ala Lys Phe Glu Thr 
        195                 200                 205             

Phe Pro Val Trp Asn Leu Pro Leu His His Pro Val Asn Leu Ala Tyr 
    210                 215                 220                 

Glu Ala Ala Thr Ala Asp Leu Asp Asp Val Asn Met Ile Asp Pro Phe 
225                 230                 235                 240 

His Leu Gln Thr Tyr Gly Glu Thr Thr Val Asn Tyr Asn Arg Asp Ile 
                245                 250                 255     

Glu Ile Phe Pro Val Leu Lys Arg Met Leu Glu Arg Ile Leu Gly Lys 
            260                 265                 270         

Ser Pro Tyr Ala Ser Pro Thr Asp Met Gly Val Asn Met Val Gly Phe 
        275                 280                 285             

Ala Ile Thr Asp Asp Glu Ala Ala Val Glu Ala Ser Lys Gln Glu Ile 
    290                 295                 300                 

Ile Arg Arg Tyr Tyr Gln Thr Val Leu Asp Phe Lys Ala Glu Lys Val 
305                 310                 315                 320 

Gly Glu Ala Ala Val Lys Lys Ile Glu Leu Leu Met Asn Asp Leu Gly 
                325                 330                 335     

Ile Thr Pro Ala Asp Arg Lys Val Ala Val Val Ala Arg Gln Lys Ala 
            340                 345                 350         

Glu Glu Thr Gly Gly Pro Ala Leu Ala Phe Glu Leu Pro Asn Gly Glu 
        355                 360                 365             

Ile Ile Thr Gly Lys Asn Ser Glu Leu Phe Gly Pro Thr Ala Ala Ala 
    370                 375                 380                 

Leu Ile Asn Ala Ile Lys Lys Ser Ala Asp Ile Ala Lys Glu Val Lys 
385                 390                 395                 400 

Leu Ile Glu Pro Glu Val Val Lys Pro Ile Gln Gly Leu Lys Ile Asp 
                405                 410                 415     

His Leu Gly Ser Arg Asn Pro Arg Leu His Ser Asn Glu Ile Leu Ile 
            420                 425                 430         

Ala Leu Ala Ile Thr Ala Thr Glu Asn Pro Asp Ala Ala Arg Ala Met 
        435                 440                 445             

Glu Glu Leu Gly Asn Leu Lys Gly Ser Glu Ala His Ser Thr Ile Ile 
    450                 455                 460                 

Leu Thr Asp Glu Asp Lys Asn Val Leu Arg Lys Leu Gly Ile Asn Val 
465                 470                 475                 480 

Thr Phe Asp Pro Tyr Tyr Gln Tyr Asp Arg Leu Tyr Arg Lys 
                485                 490                 

<210>   515
<211>   1605
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   515
atgcaagaaa aatggtggca caatgccgta gtctatcaag tctatccaaa gagttttatg   60
gatagtaatg gagatggagt tggtgatttg ccaggtatta ccagtaagtt ggactatcta   120
gctaagctag gaatcacagc aatttggctt tctcccgttt atgacagccc tatggatgat   180
aatggctatg atattgctga ttatcaagcg attgcggcta tttttggaac catggaggac   240
atggatcagc tgattgcaga agctaagaag cgtgacattc gtatcatcat ggacttggtg   300
gtcaatcata cctcagatga acatgcttgg tttgtcgaag cctgtgaaaa tactgacagc   360
cctgagcgag actactatat ctggcgcgat gaacccaatg acctagattc tatctttagt   420
gggtctgctt gggaatacga tgaaaagtca ggtcaatact atctccactt tttcagcaag   480
aaacagccgg atctcaactg ggaaaatgaa aaacttcgcc agaaaattta tgagatgatg   540
aacttctgga ttgataaagg tattggtggt ttccgtatgg atgttattga catgattggc   600
aaaattcctg acgagaaggt agtcaataat ggtcctatgc tccatcccta tctcaaggaa   660
atgaatcagg cgacctttgg agataaggat ctcttgacag taggggagac ttggggagca   720
actccagaga ttgccaagtt ctactctgat ccaaaggggc aagaattgtc tatggtcttc   780
cagtttgaac atatcggtct tcagtatcag gaaggtcagc ctaaatggca ctatcaaaaa   840
gagctgaata tcgctaagtt aaaagaaatc ttcaacaaat ggcagacaga gttaggagtt   900
gaggacggct ggaattccct cttctggaac aaccatgacc tccctcgtat tgtctcaatc   960
tggggaaatg accaagaata ccgcgaaaaa tctgccaaag cctttgcaat cttacttcat   1020
ctcatgagag gaactcctta tatctaccaa ggtgaggaga ttgggatgac caactatccg   1080
tttgaaacac tggatcaagt agaagatatt gaatctctca actatgcgcg tgaggctctt   1140
gaaaaaggtg ttccgattga agaaatcatg gacagtatcc gtgttattgg acgtgacaat   1200
gcccgtaccc ctatgcaatg ggacgagagc aaaaacgctg gtttctcaac aggtcaacct   1260
tggttggcgg ttaatccaaa ttacgagatg atcaatgtcc aagaagcgct ggcaaatcca   1320
gattctattt tctataccta tcagaaactg gtccaaattc gcaaggagaa tagctggcta   1380
gttcgagctg actttgaatt gcttgatacg gctgataagg tctttgctta tatacgtaag   1440
gatggcgacc gtcgcttcct agttgtggct aacttgtcca atgaagagca agacttgaca   1500
gtagaaggaa aagtcaaatc tgtcttgatt gaaaacactg cggctaaaga agtacttgaa   1560
aaacaggtct tggctccatg ggatgctttc tgtgtggaat tacta                   1605

<210>   516
<211>   535
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucan 1,6-alpha-glucosidase (dexB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902354 (0.E+01)

<400>   516
Met Gln Glu Lys Trp Trp His Asn Ala Val Val Tyr Gln Val Tyr Pro 
1               5                   10                  15      

Lys Ser Phe Met Asp Ser Asn Gly Asp Gly Val Gly Asp Leu Pro Gly 
            20                  25                  30          

Ile Thr Ser Lys Leu Asp Tyr Leu Ala Lys Leu Gly Ile Thr Ala Ile 
        35                  40                  45              

Trp Leu Ser Pro Val Tyr Asp Ser Pro Met Asp Asp Asn Gly Tyr Asp 

    50                  55                  60                  

Ile Ala Asp Tyr Gln Ala Ile Ala Ala Ile Phe Gly Thr Met Glu Asp 
65                  70                  75                  80  

Met Asp Gln Leu Ile Ala Glu Ala Lys Lys Arg Asp Ile Arg Ile Ile 
                85                  90                  95      

Met Asp Leu Val Val Asn His Thr Ser Asp Glu His Ala Trp Phe Val 
            100                 105                 110         

Glu Ala Cys Glu Asn Thr Asp Ser Pro Glu Arg Asp Tyr Tyr Ile Trp 
        115                 120                 125             

Arg Asp Glu Pro Asn Asp Leu Asp Ser Ile Phe Ser Gly Ser Ala Trp 
    130                 135                 140                 

Glu Tyr Asp Glu Lys Ser Gly Gln Tyr Tyr Leu His Phe Phe Ser Lys 
145                 150                 155                 160 

Lys Gln Pro Asp Leu Asn Trp Glu Asn Glu Lys Leu Arg Gln Lys Ile 
                165                 170                 175     

Tyr Glu Met Met Asn Phe Trp Ile Asp Lys Gly Ile Gly Gly Phe Arg 
            180                 185                 190         

Met Asp Val Ile Asp Met Ile Gly Lys Ile Pro Asp Glu Lys Val Val 
        195                 200                 205             

Asn Asn Gly Pro Met Leu His Pro Tyr Leu Lys Glu Met Asn Gln Ala 
    210                 215                 220                 

Thr Phe Gly Asp Lys Asp Leu Leu Thr Val Gly Glu Thr Trp Gly Ala 
225                 230                 235                 240 

Thr Pro Glu Ile Ala Lys Phe Tyr Ser Asp Pro Lys Gly Gln Glu Leu 
                245                 250                 255     

Ser Met Val Phe Gln Phe Glu His Ile Gly Leu Gln Tyr Gln Glu Gly 
            260                 265                 270         

Gln Pro Lys Trp His Tyr Gln Lys Glu Leu Asn Ile Ala Lys Leu Lys 
        275                 280                 285             

Glu Ile Phe Asn Lys Trp Gln Thr Glu Leu Gly Val Glu Asp Gly Trp 
    290                 295                 300                 

Asn Ser Leu Phe Trp Asn Asn His Asp Leu Pro Arg Ile Val Ser Ile 
305                 310                 315                 320 

Trp Gly Asn Asp Gln Glu Tyr Arg Glu Lys Ser Ala Lys Ala Phe Ala 
                325                 330                 335     

Ile Leu Leu His Leu Met Arg Gly Thr Pro Tyr Ile Tyr Gln Gly Glu 
            340                 345                 350         

Glu Ile Gly Met Thr Asn Tyr Pro Phe Glu Thr Leu Asp Gln Val Glu 
        355                 360                 365             

Asp Ile Glu Ser Leu Asn Tyr Ala Arg Glu Ala Leu Glu Lys Gly Val 
    370                 375                 380                 

Pro Ile Glu Glu Ile Met Asp Ser Ile Arg Val Ile Gly Arg Asp Asn 
385                 390                 395                 400 

Ala Arg Thr Pro Met Gln Trp Asp Glu Ser Lys Asn Ala Gly Phe Ser 
                405                 410                 415     

Thr Gly Gln Pro Trp Leu Ala Val Asn Pro Asn Tyr Glu Met Ile Asn 
            420                 425                 430         

Val Gln Glu Ala Leu Ala Asn Pro Asp Ser Ile Phe Tyr Thr Tyr Gln 
        435                 440                 445             

Lys Leu Val Gln Ile Arg Lys Glu Asn Ser Trp Leu Val Arg Ala Asp 
    450                 455                 460                 

Phe Glu Leu Leu Asp Thr Ala Asp Lys Val Phe Ala Tyr Ile Arg Lys 
465                 470                 475                 480 

Asp Gly Asp Arg Arg Phe Leu Val Val Ala Asn Leu Ser Asn Glu Glu 
                485                 490                 495     

Gln Asp Leu Thr Val Glu Gly Lys Val Lys Ser Val Leu Ile Glu Asn 
            500                 505                 510         

Thr Ala Ala Lys Glu Val Leu Glu Lys Gln Val Leu Ala Pro Trp Asp 
        515                 520                 525             

Ala Phe Cys Val Glu Leu Leu 
    530                 535 

<210>   517
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   517
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattgtt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg tgggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   518
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   518
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   519
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   519
ttggttgcag gtctaacaaa tggtgagtta atcgctccaa taacttacga agagacgatg   60
acgagcgact tttttgaagc ttggtttcag aaatttctct taccaacatt aaacacacca   120
tcggttatta ttatggataa tgcaagattc catagaatgg gtaagttaga actcttgtgt   180
gaagagtttg ggtataaact tttacctctt cctccctact cacctgagta caatcctatt   240
gagaaaacat gggctcatat caaaaagcac ctcaaaaagg tattaccaag ttgcaatacc   300
ttttatgagg ctcttttgtc ttgttcttgt ttcaat                             336

<210>   520
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903941 (2.E-46)

<400>   520
Met Val Ala Gly Leu Thr Asn Gly Glu Leu Ile Ala Pro Ile Thr Tyr 
1               5                   10                  15      

Glu Glu Thr Met Thr Ser Asp Phe Phe Glu Ala Trp Phe Gln Lys Phe 
            20                  25                  30          

Leu Leu Pro Thr Leu Asn Thr Pro Ser Val Ile Ile Met Asp Asn Ala 
        35                  40                  45              

Arg Phe His Arg Met Gly Lys Leu Glu Leu Leu Cys Glu Glu Phe Gly 
    50                  55                  60                  

Tyr Lys Leu Leu Pro Leu Pro Pro Tyr Ser Pro Glu Tyr Asn Pro Ile 
65                  70                  75                  80  

Glu Lys Thr Trp Ala His Ile Lys Lys His Leu Lys Lys Val Leu Pro 
                85                  90                  95      

Ser Cys Asn Thr Phe Tyr Glu Ala Leu Leu Ser Cys Ser Cys Phe Asn 
            100                 105                 110         


<210>   521
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   521
atgtggtata atcttcttat ggcatattca atagattttc gtaaaaaagt tctctcttat   60
tgtgagcgaa caggtagtat aacagaagca tcacacgttt tccaaatatc acgtaatacc   120
atttatggct ggttaaagct aaaagagaaa acaggagagc taaaccacca agtaaaagga   180
acaaaaccaa gaaaagttga tagagataga cttaaaaact atcttactga caatccagac   240
gcttatttga ctgaaatagc ttctgaattt ggctgtcatc caactaccat ccactatgcg   300
ctcaaagcta tgggctacac tcgaaaaaaa gaaccacacc tacta                   345

<210>   522
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1 FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902766 (6.E-66)

<400>   522
Met Trp Tyr Asn Leu Leu Met Ala Tyr Ser Ile Asp Phe Arg Lys Lys 
1               5                   10                  15      

Val Leu Ser Tyr Cys Glu Arg Thr Gly Ser Ile Thr Glu Ala Ser His 
            20                  25                  30          

Val Phe Gln Ile Ser Arg Asn Thr Ile Tyr Gly Trp Leu Lys Leu Lys 
        35                  40                  45              

Glu Lys Thr Gly Glu Leu Asn His Gln Val Lys Gly Thr Lys Pro Arg 
    50                  55                  60                  

Lys Val Asp Arg Asp Arg Leu Lys Asn Tyr Leu Thr Asp Asn Pro Asp 
65                  70                  75                  80  

Ala Tyr Leu Thr Glu Ile Ala Ser Glu Phe Gly Cys His Pro Thr Thr 
                85                  90                  95      

Ile His Tyr Ala Leu Lys Ala Met Gly Tyr Thr Arg Lys Lys Glu Pro 
            100                 105                 110         

His Leu Leu 
        115 

<210>   523
<211>   1443
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   523
atgagtagac gttttaaaaa atcacgttca cagaaagtga agcgaagtgt taatatagtt   60
ttgctgacta tttatttatt gttagtttgt tttttattgt tcttaatctt taagtacaat   120
atccttgctt ttagatatct taatctagtg gtaactgcgt tagtcctact agttgccttg   180
gtagggctac tcttgattat ctataaaaaa gctgaaaagt ttactatttt tctgttggtg   240
ttctctatcc ttgtcagctc tgtgtcgctc tttgcagtac agcagtttgt tggactgacc   300
aatcgtttaa atgcgacttc taattactca gaatattcaa tcagtgtcgc tgttttagca   360
gatagtgaga tcgaaaatgt tacgcaactg acgagtgtga cagcaccgac tgggactaat   420
aatgaaaata ttcagaaatt actagctgat atcaagtcaa gtcagaatac cgatttgacg   480
gtcaaccaga gttcgtctta cttggcagct tacaagagtt tgattgcagg ggagactaag   540
gccattgtcc taaatagtgt ctttgaaaac atcatcgagt cagagtatcc agactacgca   600
tcgaagataa aaaagattta tactaaggga ttcactaaaa aagtagaagc tcctaagacg   660
tctaagagtc agtctttcaa tatctatgtt agtggaattg acacctatgg tcctattagt   720
tcggtgtcgc gatcagatgt caacatcctg atgactgtca atcgagatac caagaaaatc   780
ctcttgacca caacgccacg tgatgcctat gtaccaatcg cagatggtgg aaataatcaa   840
aaagataaat tgactcatgc gggcatttat ggagttgatt cgtccattca caccttagaa   900
aatctctatg gagtggatat caattactat gtgcgattga acttcacttc gtttttgaaa   960
ttgattgatt tgttgggtgg aattgatgtt tataatgatc aagaatttac tgcccatacg   1020
aatggaaagt attaccctgc aggcaatgtt catcttgatt cagaacaggc tctcggtttt   1080
gttcgtgagc gctactccct agcagatggc gatcgtgacc gcgggcgcca tcaacaaaag   1140
gtgattgtgg ctatccttca aaaattaacg tcaaccgaag tgctgaaaaa ttatagtacg   1200
atcattaata gcttgcaaga ttctatccaa acaaatatgc cacttgagac catgataaat   1260
ttggtcaatg ctcagttaga aagtggaggg aattataaag taaattctca agatttaaaa   1320
gggacaggtc ggatggatct tccttcttat gcaatgccag acagtaacct ctatgtgatg   1380
gaaatagatg atagtagttt agctgtagtt aaagcagcta tacaggatgt gatggagggt   1440
aga                                                                 1443

<210>   524
<211>   481
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein Cps4A (cps4A)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902358 (e-160)

<400>   524
Met Ser Arg Arg Phe Lys Lys Ser Arg Ser Gln Lys Val Lys Arg Ser 
1               5                   10                  15      

Val Asn Ile Val Leu Leu Thr Ile Tyr Leu Leu Leu Val Cys Phe Leu 
            20                  25                  30          

Leu Phe Leu Ile Phe Lys Tyr Asn Ile Leu Ala Phe Arg Tyr Leu Asn 
        35                  40                  45              

Leu Val Val Thr Ala Leu Val Leu Leu Val Ala Leu Val Gly Leu Leu 
    50                  55                  60                  

Leu Ile Ile Tyr Lys Lys Ala Glu Lys Phe Thr Ile Phe Leu Leu Val 
65                  70                  75                  80  

Phe Ser Ile Leu Val Ser Ser Val Ser Leu Phe Ala Val Gln Gln Phe 
                85                  90                  95      

Val Gly Leu Thr Asn Arg Leu Asn Ala Thr Ser Asn Tyr Ser Glu Tyr 
            100                 105                 110         

Ser Ile Ser Val Ala Val Leu Ala Asp Ser Glu Ile Glu Asn Val Thr 
        115                 120                 125             

Gln Leu Thr Ser Val Thr Ala Pro Thr Gly Thr Asn Asn Glu Asn Ile 
    130                 135                 140                 

Gln Lys Leu Leu Ala Asp Ile Lys Ser Ser Gln Asn Thr Asp Leu Thr 
145                 150                 155                 160 

Val Asn Gln Ser Ser Ser Tyr Leu Ala Ala Tyr Lys Ser Leu Ile Ala 
                165                 170                 175     

Gly Glu Thr Lys Ala Ile Val Leu Asn Ser Val Phe Glu Asn Ile Ile 
            180                 185                 190         

Glu Ser Glu Tyr Pro Asp Tyr Ala Ser Lys Ile Lys Lys Ile Tyr Thr 
        195                 200                 205             

Lys Gly Phe Thr Lys Lys Val Glu Ala Pro Lys Thr Ser Lys Ser Gln 
    210                 215                 220                 

Ser Phe Asn Ile Tyr Val Ser Gly Ile Asp Thr Tyr Gly Pro Ile Ser 
225                 230                 235                 240 

Ser Val Ser Arg Ser Asp Val Asn Ile Leu Met Thr Val Asn Arg Asp 
                245                 250                 255     

Thr Lys Lys Ile Leu Leu Thr Thr Thr Pro Arg Asp Ala Tyr Val Pro 
            260                 265                 270         

Ile Ala Asp Gly Gly Asn Asn Gln Lys Asp Lys Leu Thr His Ala Gly 
        275                 280                 285             

Ile Tyr Gly Val Asp Ser Ser Ile His Thr Leu Glu Asn Leu Tyr Gly 
    290                 295                 300                 

Val Asp Ile Asn Tyr Tyr Val Arg Leu Asn Phe Thr Ser Phe Leu Lys 
305                 310                 315                 320 

Leu Ile Asp Leu Leu Gly Gly Ile Asp Val Tyr Asn Asp Gln Glu Phe 
                325                 330                 335     

Thr Ala His Thr Asn Gly Lys Tyr Tyr Pro Ala Gly Asn Val His Leu 
            340                 345                 350         

Asp Ser Glu Gln Ala Leu Gly Phe Val Arg Glu Arg Tyr Ser Leu Ala 
        355                 360                 365             

Asp Gly Asp Arg Asp Arg Gly Arg His Gln Gln Lys Val Ile Val Ala 
    370                 375                 380                 

Ile Leu Gln Lys Leu Thr Ser Thr Glu Val Leu Lys Asn Tyr Ser Thr 
385                 390                 395                 400 

Ile Ile Asn Ser Leu Gln Asp Ser Ile Gln Thr Asn Met Pro Leu Glu 
                405                 410                 415     

Thr Met Ile Asn Leu Val Asn Ala Gln Leu Glu Ser Gly Gly Asn Tyr 
            420                 425                 430         

Lys Val Asn Ser Gln Asp Leu Lys Gly Thr Gly Arg Met Asp Leu Pro 
        435                 440                 445             

Ser Tyr Ala Met Pro Asp Ser Asn Leu Tyr Val Met Glu Ile Asp Asp 
    450                 455                 460                 

Ser Ser Leu Ala Val Val Lys Ala Ala Ile Gln Asp Val Met Glu Gly 
465                 470                 475                 480 

Arg 
    

<210>   525
<211>   729
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   525
atgatagaca tccattcgca tatcgttttt gatgtagatg acggtcccaa gtcaagagag   60
gaaagcaagg ctctcttggc agaatcctac agacaggggg tgcgaaccat tgtttctacc   120
tctcaccgtc gcaagggcat gtttgaaact ccggaagaga agatagcaga aaactttctt   180
caggttcggg aaatagctaa ggaagtggcg agtgacttgg tcattgctta cggggctgaa   240
atttattaca caccagatgt tctggataag ctggaaaaaa agcggattcc gaccctcaat   300
gatagtcgtt atgccttgat agagtttagt atgaacactc cttatcgcga tattcatagc   360
gccttgagca agatcttgat gttgggaatt actccagtca ttgcccacat tgagcgctat   420
gatgctcttg aaaataatga aaaacgcgtt cgagaactga tcgatatggg ctgttacacg   480
caagtaaata gttcacatgt cctcaaaccc aaactttttg gcgaacgtta taaattcatg   540
aaaaaaagag ctcagtattt tttagagcag gatttggttc atgtcattgc aagtgatatg   600
cacaatctag acggtagacc tcctcatatg gcagaagcat atgaccttgt tacccaaaaa   660
tacggagaag cgaaggctca ggaacttttt atagacaatc ctcgaaaaat tgtaatggat   720
caactaatt                                                           729

<210>   526
<211>   243
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein Cps4B (cps4B)
<223>   Cellular location: membrane

<400>   526
Met Ile Asp Ile His Ser His Ile Val Phe Asp Val Asp Asp Gly Pro 
1               5                   10                  15      

Lys Ser Arg Glu Glu Ser Lys Ala Leu Leu Ala Glu Ser Tyr Arg Gln 
            20                  25                  30          

Gly Val Arg Thr Ile Val Ser Thr Ser His Arg Arg Lys Gly Met Phe 
        35                  40                  45              

Glu Thr Pro Glu Glu Lys Ile Ala Glu Asn Phe Leu Gln Val Arg Glu 
    50                  55                  60                  

Ile Ala Lys Glu Val Ala Ser Asp Leu Val Ile Ala Tyr Gly Ala Glu 
65                  70                  75                  80  

Ile Tyr Tyr Thr Pro Asp Val Leu Asp Lys Leu Glu Lys Lys Arg Ile 
                85                  90                  95      

Pro Thr Leu Asn Asp Ser Arg Tyr Ala Leu Ile Glu Phe Ser Met Asn 
            100                 105                 110         

Thr Pro Tyr Arg Asp Ile His Ser Ala Leu Ser Lys Ile Leu Met Leu 
        115                 120                 125             

Gly Ile Thr Pro Val Ile Ala His Ile Glu Arg Tyr Asp Ala Leu Glu 
    130                 135                 140                 

Asn Asn Glu Lys Arg Val Arg Glu Leu Ile Asp Met Gly Cys Tyr Thr 
145                 150                 155                 160 

Gln Val Asn Ser Ser His Val Leu Lys Pro Lys Leu Phe Gly Glu Arg 
                165                 170                 175     

Tyr Lys Phe Met Lys Lys Arg Ala Gln Tyr Phe Leu Glu Gln Asp Leu 
            180                 185                 190         

Val His Val Ile Ala Ser Asp Met His Asn Leu Asp Gly Arg Pro Pro 
        195                 200                 205             

His Met Ala Glu Ala Tyr Asp Leu Val Thr Gln Lys Tyr Gly Glu Ala 
    210                 215                 220                 

Lys Ala Gln Glu Leu Phe Ile Asp Asn Pro Arg Lys Ile Val Met Asp 
225                 230                 235                 240 

Gln Leu Ile 
            

<210>   527
<211>   693
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   527
atgatgaaag aacaaaatac gatagaaatc gatgtatttc aattagttaa aagcttgtgg   60
aaacgcaagc taatgatttt aatagtggca cttgtgacag gtgcgggggc ttttgcatat   120
agcactttta ttgttaagcc agaatatacg agtaccacgc gaatttacgt agtgaatcgc   180
aatcaaggag acaagccggg gttgacaaat caggatttgc aggcaggaac ttatctggta   240
aaagactacc gtgagattat cctttcgcag gatgttttgg aggaagttgt ttctgatttg   300
aaactagatt tgacgccaaa aggtttggct aataaaatta aagtgacagt accagttgat   360
acccgtattg tctctatttc agttaatgat cgagttcctg aagaggcaag ccgtatcgct   420
aactctttga gagaagtagc tgctcaaaaa attatcagta ttactcgtgt ttctgacgtg   480
acaacactgg aggaggcaag gccggcgata tccccgtctt cgccaaatat taaacgcaat   540
acactaattg gttttttggc aggggtgatt ggaactagtg ttatagttct tcatcttgaa   600
cttttggata ctcgtgtgaa acgtccggaa gatatcgaaa atacattgca gatgacactt   660
ttgggagttg tgccaaactt gggtaagttg aaa                                693

<210>   528
<211>   231
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein Cps4C (cps4C)
<223>   Cellular location: membrane

<400>   528
Met Met Lys Glu Gln Asn Thr Ile Glu Ile Asp Val Phe Gln Leu Val 
1               5                   10                  15      

Lys Ser Leu Trp Lys Arg Lys Leu Met Ile Leu Ile Val Ala Leu Val 
            20                  25                  30          

Thr Gly Ala Gly Ala Phe Ala Tyr Ser Thr Phe Ile Val Lys Pro Glu 
        35                  40                  45              

Tyr Thr Ser Thr Thr Arg Ile Tyr Val Val Asn Arg Asn Gln Gly Asp 
    50                  55                  60                  

Lys Pro Gly Leu Thr Asn Gln Asp Leu Gln Ala Gly Thr Tyr Leu Val 
65                  70                  75                  80  

Lys Asp Tyr Arg Glu Ile Ile Leu Ser Gln Asp Val Leu Glu Glu Val 
                85                  90                  95      

Val Ser Asp Leu Lys Leu Asp Leu Thr Pro Lys Gly Leu Ala Asn Lys 
            100                 105                 110         

Ile Lys Val Thr Val Pro Val Asp Thr Arg Ile Val Ser Ile Ser Val 
        115                 120                 125             

Asn Asp Arg Val Pro Glu Glu Ala Ser Arg Ile Ala Asn Ser Leu Arg 
    130                 135                 140                 

Glu Val Ala Ala Gln Lys Ile Ile Ser Ile Thr Arg Val Ser Asp Val 
145                 150                 155                 160 

Thr Thr Leu Glu Glu Ala Arg Pro Ala Ile Ser Pro Ser Ser Pro Asn 
                165                 170                 175     

Ile Lys Arg Asn Thr Leu Ile Gly Phe Leu Ala Gly Val Ile Gly Thr 
            180                 185                 190         

Ser Val Ile Val Leu His Leu Glu Leu Leu Asp Thr Arg Val Lys Arg 
        195                 200                 205             

Pro Glu Asp Ile Glu Asn Thr Leu Gln Met Thr Leu Leu Gly Val Val 
    210                 215                 220                 

Pro Asn Leu Gly Lys Leu Lys 
225                 230     

<210>   529
<211>   681
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   529
atgccgacat tagaaatagc acaaaaaaaa ctggagttca ttaagaaggc agaagaatat   60
tacaatgcct tgtgtacaaa tatacagttg agcggagata aactaaaagt aatttccgtt   120
acttctgtta accctgggga aggaaaaaca actacttcca taaatatagc atggtcgttt   180
gcgcgtgcag gctataaaac tcttttgatc gatggcgata ctcgaaattc agttatgtta   240
ggagttttta aatctcgtga aaaaattaca gggctaacag aatttttatc tgggacagct   300
gatttatctc acggtttatg tgatacaaat attgaaaatt tatttgtagt tcaatcggga   360
tctgtatcac caaaccctac agccttgtta caaagtaaaa attttaatga tatgattgaa   420
acattgcgta aatattttga ttatatcatt attgatacac cgcctattgg aattgttatt   480
gatgcggcaa ttatcactca aaagtgtgat gcgtccatct tggtaacagc aacaggtgag   540
gcgaataaac gtgatatcca aaaagcgaaa caacaattaa aacaaacagg gaaactgttc   600
ctaggagttg ttttaaataa attggatatc tcggttaata agtatggagt ttacggttcc   660
tatggaaatt atggtaaaaa a                                             681

<210>   530
<211>   227
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein Cps4D (cps4D)
<223>   Cellular location: membrane

<400>   530
Met Pro Thr Leu Glu Ile Ala Gln Lys Lys Leu Glu Phe Ile Lys Lys 
1               5                   10                  15      

Ala Glu Glu Tyr Tyr Asn Ala Leu Cys Thr Asn Ile Gln Leu Ser Gly 
            20                  25                  30          

Asp Lys Leu Lys Val Ile Ser Val Thr Ser Val Asn Pro Gly Glu Gly 
        35                  40                  45              

Lys Thr Thr Thr Ser Ile Asn Ile Ala Trp Ser Phe Ala Arg Ala Gly 
    50                  55                  60                  

Tyr Lys Thr Leu Leu Ile Asp Gly Asp Thr Arg Asn Ser Val Met Leu 
65                  70                  75                  80  

Gly Val Phe Lys Ser Arg Glu Lys Ile Thr Gly Leu Thr Glu Phe Leu 
                85                  90                  95      

Ser Gly Thr Ala Asp Leu Ser His Gly Leu Cys Asp Thr Asn Ile Glu 
            100                 105                 110         

Asn Leu Phe Val Val Gln Ser Gly Ser Val Ser Pro Asn Pro Thr Ala 
        115                 120                 125             

Leu Leu Gln Ser Lys Asn Phe Asn Asp Met Ile Glu Thr Leu Arg Lys 
    130                 135                 140                 

Tyr Phe Asp Tyr Ile Ile Ile Asp Thr Pro Pro Ile Gly Ile Val Ile 
145                 150                 155                 160 

Asp Ala Ala Ile Ile Thr Gln Lys Cys Asp Ala Ser Ile Leu Val Thr 
                165                 170                 175     

Ala Thr Gly Glu Ala Asn Lys Arg Asp Ile Gln Lys Ala Lys Gln Gln 
            180                 185                 190         

Leu Lys Gln Thr Gly Lys Leu Phe Leu Gly Val Val Leu Asn Lys Leu 
        195                 200                 205             

Asp Ile Ser Val Asn Lys Tyr Gly Val Tyr Gly Ser Tyr Gly Asn Tyr 
    210                 215                 220                 

Gly Lys Lys 
225         

<210>   531
<211>   651

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   531
ttgtcaaatg gaaatagaat gaaaaatgga aatagaattt atagttggag gttgtttatg   60
tacggtataa taaaacgatt aggtgatata ttattatctt taatagggat aataatattg   120
tgtccggttt ttatgataat tgcaattgcg attaaacttg attcagaagg tccggttata   180
tttaagcaaa aacgctttgg tattcataaa gaatacttct atattttgaa atttaggtct   240
atgaaaatag atgcacctaa aaatgtggcg cctcgaaact tatataatcc agagcaatgg   300
attacaaaag taggggcttt cttgcgaaaa acatctttgg atgaactacc acaattgttt   360
aatattcttg ttggtaatat gagtattgta ggtcctagac cagcgggtat aaatgaacta   420
gatttgattg cagagagaga taagtatgga gcaaatgata tcttgccagg gttaactgga   480
tgggcacaaa ttaacgggcg tgatactttg tctgttgaga tgaagacgga gttagatggc   540
tactatgtta aacatctgtc tttgataatg gatattagat gtatagttaa gacaatacct   600
tacgtactga aacgaaaagg tattgtagag ggtagtggta agaaagaaag t            651

<210>   532
<211>   217
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein Cps4E (cps4E)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903697 (6.E-24)

<400>   532
Met Ser Asn Gly Asn Arg Met Lys Asn Gly Asn Arg Ile Tyr Ser Trp 
1               5                   10                  15      

Arg Leu Phe Met Tyr Gly Ile Ile Lys Arg Leu Gly Asp Ile Leu Leu 
            20                  25                  30          

Ser Leu Ile Gly Ile Ile Ile Leu Cys Pro Val Phe Met Ile Ile Ala 
        35                  40                  45              

Ile Ala Ile Lys Leu Asp Ser Glu Gly Pro Val Ile Phe Lys Gln Lys 
    50                  55                  60                  

Arg Phe Gly Ile His Lys Glu Tyr Phe Tyr Ile Leu Lys Phe Arg Ser 
65                  70                  75                  80  

Met Lys Ile Asp Ala Pro Lys Asn Val Ala Pro Arg Asn Leu Tyr Asn 
                85                  90                  95      

Pro Glu Gln Trp Ile Thr Lys Val Gly Ala Phe Leu Arg Lys Thr Ser 
            100                 105                 110         

Leu Asp Glu Leu Pro Gln Leu Phe Asn Ile Leu Val Gly Asn Met Ser 
        115                 120                 125             

Ile Val Gly Pro Arg Pro Ala Gly Ile Asn Glu Leu Asp Leu Ile Ala 
    130                 135                 140                 

Glu Arg Asp Lys Tyr Gly Ala Asn Asp Ile Leu Pro Gly Leu Thr Gly 
145                 150                 155                 160 

Trp Ala Gln Ile Asn Gly Arg Asp Thr Leu Ser Val Glu Met Lys Thr 
                165                 170                 175     

Glu Leu Asp Gly Tyr Tyr Val Lys His Leu Ser Leu Ile Met Asp Ile 
            180                 185                 190         

Arg Cys Ile Val Lys Thr Ile Pro Tyr Val Leu Lys Arg Lys Gly Ile 
        195                 200                 205             

Val Glu Gly Ser Gly Lys Lys Glu Ser 
    210                 215         

<210>   533
<211>   1227
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   533
atgaaaatac tatttgtttg ccaacattat aagccagaac cattcaggtt gtcagatatt   60
tgtgaagatt tagttcgaaa agggcatgaa gtctctgttt tggctgggat tcctaattac   120
cctgaaggga agatatatgc agattatcgt cataataaaa aaagacgtga gattatagaa   180
ggtgttacga tatatcgttc ttatacaatc cctagaaaaa aaagtgttgt atttcgattg   240
ttgaattatt ttagctttgc aattagttct actttaggag ttttattggg gaggtataaa   300
acgaaagatg gatcgaattt tgactgtgta ttcgttaacc aattgtctcc agttatgatg   360
gcatgggctg gtatggctta taaaaaaaaa tataagaaac cgatgtttct atattgtatg   420
gatgtttggc cagatagttt aaccgtaggt ggagtgaaac aagatggctt gattttcaag   480
ctgtttaaat ttatctcaaa aaaagtttac cgagctagtg attatatatt tgtcactagt   540
ccatcattta aaaattattt tgtgaagcaa tttgacatat ccgaacaaaa gattacatat   600
ttgccacaat atgcagaaga tctttttatc cctgatgaat ctatagttaa taaagaaagt   660
gttgacctaa cttttgctgg taatattggc aaagcacaaa atttggaaac tattttgaaa   720
gctgccagtt tgatagagaa gaataccaat ttacccaaga aaattcattt tcattttgtt   780
ggagatggta cggaattgtt aagcatgaaa gcattagctc atgaattgga gttaaagaat   840
atttccttct atggaagacg ttctttggag gaaatgccat ccttctataa aaaatcagat   900
gctatgttag tttctttaat aggagactcg atagtttctc gtactatacc tgggaaggta   960
caatcttata tggcggcagg caaaccaatt ataggtgcaa tttcaggaga tgctaaaata   1020
attgtagaag aagcaaattg tggatatgtt agtcccgaac gagatgtaaa acaattggca   1080
aaaaatattt gtaaatttag tatgttatct attaagagac aaagagagtt aggaaagaaa   1140
gctcgttgtt actatgaaaa tcacttttca aaagagcagt ttatgctcga actggagaca   1200
tgtttagaga gggaaagtaa gaaagaa                                       1227

<210>   534
<211>   409
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein Cps4F (cps4F)
<223>   Cellular location: cytoplasm

<400>   534
Met Lys Ile Leu Phe Val Cys Gln His Tyr Lys Pro Glu Pro Phe Arg 
1               5                   10                  15      

Leu Ser Asp Ile Cys Glu Asp Leu Val Arg Lys Gly His Glu Val Ser 
            20                  25                  30          

Val Leu Ala Gly Ile Pro Asn Tyr Pro Glu Gly Lys Ile Tyr Ala Asp 
        35                  40                  45              

Tyr Arg His Asn Lys Lys Arg Arg Glu Ile Ile Glu Gly Val Thr Ile 
    50                  55                  60                  

Tyr Arg Ser Tyr Thr Ile Pro Arg Lys Lys Ser Val Val Phe Arg Leu 
65                  70                  75                  80  

Leu Asn Tyr Phe Ser Phe Ala Ile Ser Ser Thr Leu Gly Val Leu Leu 
                85                  90                  95      

Gly Arg Tyr Lys Thr Lys Asp Gly Ser Asn Phe Asp Cys Val Phe Val 
            100                 105                 110         

Asn Gln Leu Ser Pro Val Met Met Ala Trp Ala Gly Met Ala Tyr Lys 
        115                 120                 125             

Lys Lys Tyr Lys Lys Pro Met Phe Leu Tyr Cys Met Asp Val Trp Pro 
    130                 135                 140                 

Asp Ser Leu Thr Val Gly Gly Val Lys Gln Asp Gly Leu Ile Phe Lys 
145                 150                 155                 160 

Leu Phe Lys Phe Ile Ser Lys Lys Val Tyr Arg Ala Ser Asp Tyr Ile 
                165                 170                 175     

Phe Val Thr Ser Pro Ser Phe Lys Asn Tyr Phe Val Lys Gln Phe Asp 
            180                 185                 190         

Ile Ser Glu Gln Lys Ile Thr Tyr Leu Pro Gln Tyr Ala Glu Asp Leu 
        195                 200                 205             

Phe Ile Pro Asp Glu Ser Ile Val Asn Lys Glu Ser Val Asp Leu Thr 
    210                 215                 220                 

Phe Ala Gly Asn Ile Gly Lys Ala Gln Asn Leu Glu Thr Ile Leu Lys 
225                 230                 235                 240 

Ala Ala Ser Leu Ile Glu Lys Asn Thr Asn Leu Pro Lys Lys Ile His 
                245                 250                 255     

Phe His Phe Val Gly Asp Gly Thr Glu Leu Leu Ser Met Lys Ala Leu 
            260                 265                 270         

Ala His Glu Leu Glu Leu Lys Asn Ile Ser Phe Tyr Gly Arg Arg Ser 
        275                 280                 285             

Leu Glu Glu Met Pro Ser Phe Tyr Lys Lys Ser Asp Ala Met Leu Val 
    290                 295                 300                 

Ser Leu Ile Gly Asp Ser Ile Val Ser Arg Thr Ile Pro Gly Lys Val 
305                 310                 315                 320 

Gln Ser Tyr Met Ala Ala Gly Lys Pro Ile Ile Gly Ala Ile Ser Gly 
                325                 330                 335     

Asp Ala Lys Ile Ile Val Glu Glu Ala Asn Cys Gly Tyr Val Ser Pro 
            340                 345                 350         

Glu Arg Asp Val Lys Gln Leu Ala Lys Asn Ile Cys Lys Phe Ser Met 
        355                 360                 365             

Leu Ser Ile Lys Arg Gln Arg Glu Leu Gly Lys Lys Ala Arg Cys Tyr 
    370                 375                 380                 

Tyr Glu Asn His Phe Ser Lys Glu Gln Phe Met Leu Glu Leu Glu Thr 
385                 390                 395                 400 

Cys Leu Glu Arg Glu Ser Lys Lys Glu 
                405                 

<210>   535
<211>   1074
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   535
atgagagtac tgtttatact atctgataat atatatctaa ctccttactt caatttttat   60
aaagaattat tgaagaaact gtctattagt tacgatgtta tatattggga taagaatatt   120
aacgagatta ttacaaaaca aaactactat cgtatttctt tttctggtaa aggaaaatta   180
agtaagatat taggttatgt aaaattcaga aaagaaatta aaaagaagct aaaagaaaat   240
gattatgata tgatattgcc gttacatagt attgtgtctt tcattttagt agattttctt   300
ctcttttcat ttaaaaatag atatatttat gatattcgtg attacagtta tgaaaaattt   360
ttggtttatc gtttggttca gaaacaattg gtgaaaaatt ctttaatgaa tatcgtttct   420
tcagacggct ataaattttt tttaccaatg ggagagtatt ttactaccca taacctaccc   480
aatatgatag aattaaacga ggtaaagcag ttaaaaaata atagtacgtt tccaattcaa   540
ctttcctaca ttggtttaat tcgttttcaa gaacaaaata aaaaaataat cgattttttt   600
gcaaatgaca gtcgatttca gttgaatttt ataggtacta atgcaggaga attaagggaa   660
ttttgtcaag aaaaaaatat cagcaatgtt aacttggtgg acacattcca gcctaaagat   720
accatgtctt tttataagaa tacagatgtt gttttgaatt tatacgggaa tcacactccc   780
ttactagact atgctttgtc taataaactc tactttgctg cattgttgta taaacctatt   840
ttagtttgtg aagatactta tatggaaaaa gtgtcaatag agaatggttt tggtttcgtt   900
ttacctatga aggatgaatc ggaaaaagat tgtttggctt tgtatattca aaaccttgac   960
aggaaacagc taattaagaa ttgtgataac ttcatggaca gaattagttt agaaaaacaa   1020
aaaacagaaa tagaattaga gaagcgaatc ttaagcttaa ggaagaagaa tgat         1074

<210>   536
<211>   358
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein Cps4G (cps4G)
<223>   Cellular location: membrane

<400>   536
Met Arg Val Leu Phe Ile Leu Ser Asp Asn Ile Tyr Leu Thr Pro Tyr 
1               5                   10                  15      

Phe Asn Phe Tyr Lys Glu Leu Leu Lys Lys Leu Ser Ile Ser Tyr Asp 
            20                  25                  30          

Val Ile Tyr Trp Asp Lys Asn Ile Asn Glu Ile Ile Thr Lys Gln Asn 
        35                  40                  45              

Tyr Tyr Arg Ile Ser Phe Ser Gly Lys Gly Lys Leu Ser Lys Ile Leu 
    50                  55                  60                  

Gly Tyr Val Lys Phe Arg Lys Glu Ile Lys Lys Lys Leu Lys Glu Asn 
65                  70                  75                  80  

Asp Tyr Asp Met Ile Leu Pro Leu His Ser Ile Val Ser Phe Ile Leu 
                85                  90                  95      

Val Asp Phe Leu Leu Phe Ser Phe Lys Asn Arg Tyr Ile Tyr Asp Ile 
            100                 105                 110         

Arg Asp Tyr Ser Tyr Glu Lys Phe Leu Val Tyr Arg Leu Val Gln Lys 
        115                 120                 125             

Gln Leu Val Lys Asn Ser Leu Met Asn Ile Val Ser Ser Asp Gly Tyr 
    130                 135                 140                 

Lys Phe Phe Leu Pro Met Gly Glu Tyr Phe Thr Thr His Asn Leu Pro 
145                 150                 155                 160 

Asn Met Ile Glu Leu Asn Glu Val Lys Gln Leu Lys Asn Asn Ser Thr 
                165                 170                 175     

Phe Pro Ile Gln Leu Ser Tyr Ile Gly Leu Ile Arg Phe Gln Glu Gln 
            180                 185                 190         

Asn Lys Lys Ile Ile Asp Phe Phe Ala Asn Asp Ser Arg Phe Gln Leu 
        195                 200                 205             

Asn Phe Ile Gly Thr Asn Ala Gly Glu Leu Arg Glu Phe Cys Gln Glu 
    210                 215                 220                 

Lys Asn Ile Ser Asn Val Asn Leu Val Asp Thr Phe Gln Pro Lys Asp 
225                 230                 235                 240 

Thr Met Ser Phe Tyr Lys Asn Thr Asp Val Val Leu Asn Leu Tyr Gly 
                245                 250                 255     

Asn His Thr Pro Leu Leu Asp Tyr Ala Leu Ser Asn Lys Leu Tyr Phe 
            260                 265                 270         

Ala Ala Leu Leu Tyr Lys Pro Ile Leu Val Cys Glu Asp Thr Tyr Met 
        275                 280                 285             

Glu Lys Val Ser Ile Glu Asn Gly Phe Gly Phe Val Leu Pro Met Lys 
    290                 295                 300                 

Asp Glu Ser Glu Lys Asp Cys Leu Ala Leu Tyr Ile Gln Asn Leu Asp 
305                 310                 315                 320 

Arg Lys Gln Leu Ile Lys Asn Cys Asp Asn Phe Met Asp Arg Ile Ser 
                325                 330                 335     

Leu Glu Lys Gln Lys Thr Glu Ile Glu Leu Glu Lys Arg Ile Leu Ser 
            340                 345                 350         

Leu Arg Lys Lys Asn Asp 
        355             

<210>   537
<211>   1116
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   537
atgattaaag tattacatct atttacaaca ctagatagtg gtggagtaga aagttttcta   60
ttcaactatt attctcacat tgatagaaaa aaaattcaat ttgattttat tgtgcctgga   120
aaagaacaag gatttttaga ggataaaatg aaagaattgg gtgcaaaggt ttatcatgtg   180
cctctattaa ggaaaaagcc tctacatcag tttctctctc ttgctagaat aataaagaaa   240
ggagattatg atatagttca ttgccatggc tataaatctg caattggtct gatcttatct   300
aaaataattg gttgtaaaat tagaattatt catagtcata tggcttatgt aacagaaaac   360
agttttcaaa aagtattgcg taaattagta acaattttgg taaaaatctt agcaactcat   420
tggtttgcat gtggggaaga ttcggctaag tggttatatg gagagaaagc gtataaagac   480
ggaaaaattg aaattatttt taatgcaatt gatttgaaaa agtatcaatt tttgtcagat   540
gttagagaaa aatgtcgtag agaattagat gtgtcaaata agttcgtatt aggaaatata   600
gctcgcctat cagatcaaaa aaaccaaagt tatttattta acgttttaaa agaactcatt   660
ttaatcaaac caaatgttat tttactccta gttggtaatg gtgaggatga gcagaaatta   720
aaacagaaag ctttagaact aaatctgacc ccatatgtgc tatttttagg gagaaggact   780
gatatttctg atttattatc tgcgatggat gtttttttgc ttccgtctaa atatgagggg   840
ttgcctgttt ctctagtaga ggctcaggca tcgggattac aaattttatc gtcagataca   900
gtgacgcaag aagtagatgt gaccaaaaac attagttact tacctatcaa cgaagagtct   960
gtgttgctat ggaaagataa agtactgtct ttaacatctg aggaatgcaa tcgttttgaa   1020
ataaataaca gtatgacaga tggactctat gatatttgtt atcaagctag taaattattg   1080
aatcgttatc aagaaatgtg tgtaataaag gagata                             1116

<210>   538
<211>   372
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein Cps4H (cps4H)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902179 (3.E-12)

<400>   538
Met Ile Lys Val Leu His Leu Phe Thr Thr Leu Asp Ser Gly Gly Val 
1               5                   10                  15      

Glu Ser Phe Leu Phe Asn Tyr Tyr Ser His Ile Asp Arg Lys Lys Ile 
            20                  25                  30          

Gln Phe Asp Phe Ile Val Pro Gly Lys Glu Gln Gly Phe Leu Glu Asp 
        35                  40                  45              

Lys Met Lys Glu Leu Gly Ala Lys Val Tyr His Val Pro Leu Leu Arg 
    50                  55                  60                  

Lys Lys Pro Leu His Gln Phe Leu Ser Leu Ala Arg Ile Ile Lys Lys 
65                  70                  75                  80  

Gly Asp Tyr Asp Ile Val His Cys His Gly Tyr Lys Ser Ala Ile Gly 
                85                  90                  95      

Leu Ile Leu Ser Lys Ile Ile Gly Cys Lys Ile Arg Ile Ile His Ser 
            100                 105                 110         

His Met Ala Tyr Val Thr Glu Asn Ser Phe Gln Lys Val Leu Arg Lys 
        115                 120                 125             


Leu Val Thr Ile Leu Val Lys Ile Leu Ala Thr His Trp Phe Ala Cys 
    130                 135                 140                 

Gly Glu Asp Ser Ala Lys Trp Leu Tyr Gly Glu Lys Ala Tyr Lys Asp 
145                 150                 155                 160 

Gly Lys Ile Glu Ile Ile Phe Asn Ala Ile Asp Leu Lys Lys Tyr Gln 
                165                 170                 175     

Phe Leu Ser Asp Val Arg Glu Lys Cys Arg Arg Glu Leu Asp Val Ser 
            180                 185                 190         

Asn Lys Phe Val Leu Gly Asn Ile Ala Arg Leu Ser Asp Gln Lys Asn 
        195                 200                 205             

Gln Ser Tyr Leu Phe Asn Val Leu Lys Glu Leu Ile Leu Ile Lys Pro 
    210                 215                 220                 

Asn Val Ile Leu Leu Leu Val Gly Asn Gly Glu Asp Glu Gln Lys Leu 
225                 230                 235                 240 

Lys Gln Lys Ala Leu Glu Leu Asn Leu Thr Pro Tyr Val Leu Phe Leu 
                245                 250                 255     

Gly Arg Arg Thr Asp Ile Ser Asp Leu Leu Ser Ala Met Asp Val Phe 
            260                 265                 270         

Leu Leu Pro Ser Lys Tyr Glu Gly Leu Pro Val Ser Leu Val Glu Ala 
        275                 280                 285             

Gln Ala Ser Gly Leu Gln Ile Leu Ser Ser Asp Thr Val Thr Gln Glu 
    290                 295                 300                 

Val Asp Val Thr Lys Asn Ile Ser Tyr Leu Pro Ile Asn Glu Glu Ser 
305                 310                 315                 320 

Val Leu Leu Trp Lys Asp Lys Val Leu Ser Leu Thr Ser Glu Glu Cys 
                325                 330                 335     

Asn Arg Phe Glu Ile Asn Asn Ser Met Thr Asp Gly Leu Tyr Asp Ile 
            340                 345                 350         

Cys Tyr Gln Ala Ser Lys Leu Leu Asn Arg Tyr Gln Glu Met Cys Val 
        355                 360                 365             

Ile Lys Glu Ile 
    370         


<210>   539
<211>   1398
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   539
atgcagacaa agtatatttg tagagtgaca ctagtgacat taagttttat atttgctttc   60
tgttacttgt tctggactct cgataattgg aataatggtt ttcttatatc taattatgtt   120
ccgtctatat ttatatgggt ttgctttcta attatttttc aaattactgg ttttatttta   180
caaaaagtta gtatatatga tttttctgta tggtatctga ttttatctta tttttttatg   240
tttggattaa ttttcaatga gtatatgggg tttcaaacaa ctctgctgtg gagccctagt   300
aacttctata ataatgaaga attatttcat tcatatattt ttataatttg gattttgttt   360
tgttattctg taggctattt atttttttat agtgatggaa aggtacatta tcattcagaa   420
gtacaaaatt atcaggaaaa tgaagagaaa attttgtaca atgcgggtag gattttaaca   480
ggagtgggct ttatttctag ggtaataact gattctaaaa cagtactagc agttagagcg   540
gcgaatagct attcagcata ttcagaggca gctagttcag gaataataga tgatttagga   600
gtacttatgc ttcctggtgt gttctccttg ttttattcag ataagctgtc ccgagttata   660
aagcgtacta ttttttgggt aatgttgttt tacctaattt tgataatgat cctaacagga   720
agtcgtaaaa tccaggtgtt ttcaatcttg gcgttggttt tagtatacac acaatcttta   780
gggattactt tttcgaagaa aagagtactt gtatttttaa tagtaactgt atttctatta   840
aatgtattag ttgttattag ggggcaccgt ttcgacttga atactatagg tatatactta   900
tttgattcct tttcttcatt agattttgta aagaatatac taggggaagt attttcagag   960
tcgggactga ccagcctaac agtagcttct gctgtaactg ttgtgcctag tagcattcca   1020
tatgaatatg ggatgacatt tctacgcact atcctatcaa tttttcctat tggatggtta   1080
gttggtgatt tttttgataa agcatcagcg acggttgtta ttaataaatt tttggggtta   1140
cctgtaggct cttcttttgt ggaagaatta ttttggaact ttggttacta tggtggtgtt   1200
ttttggagtt ttgttttggg aatatttagt ggatggcgat taaatttcag agcttttcaa   1260
acaagtaaaa tctcaaaagt tatttatttt tcggtaattt ctcaactatt gcttttagtg   1320
agaagtagtt caatagatgt ttatcgtcct attatgtata gtttgattat gatatttatt   1380
tttaggaggt tgaaaaaa                                                 1398

<210>   540
<211>   466
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   540
Met Gln Thr Lys Tyr Ile Cys Arg Val Thr Leu Val Thr Leu Ser Phe 
1               5                   10                  15      

Ile Phe Ala Phe Cys Tyr Leu Phe Trp Thr Leu Asp Asn Trp Asn Asn 
            20                  25                  30          

Gly Phe Leu Ile Ser Asn Tyr Val Pro Ser Ile Phe Ile Trp Val Cys 
        35                  40                  45              

Phe Leu Ile Ile Phe Gln Ile Thr Gly Phe Ile Leu Gln Lys Val Ser 
    50                  55                  60                  

Ile Tyr Asp Phe Ser Val Trp Tyr Leu Ile Leu Ser Tyr Phe Phe Met 
65                  70                  75                  80  

Phe Gly Leu Ile Phe Asn Glu Tyr Met Gly Phe Gln Thr Thr Leu Leu 
                85                  90                  95      

Trp Ser Pro Ser Asn Phe Tyr Asn Asn Glu Glu Leu Phe His Ser Tyr 
            100                 105                 110         

Ile Phe Ile Ile Trp Ile Leu Phe Cys Tyr Ser Val Gly Tyr Leu Phe 
        115                 120                 125             

Phe Tyr Ser Asp Gly Lys Val His Tyr His Ser Glu Val Gln Asn Tyr 
    130                 135                 140                 

Gln Glu Asn Glu Glu Lys Ile Leu Tyr Asn Ala Gly Arg Ile Leu Thr 
145                 150                 155                 160 

Gly Val Gly Phe Ile Ser Arg Val Ile Thr Asp Ser Lys Thr Val Leu 
                165                 170                 175     

Ala Val Arg Ala Ala Asn Ser Tyr Ser Ala Tyr Ser Glu Ala Ala Ser 
            180                 185                 190         

Ser Gly Ile Ile Asp Asp Leu Gly Val Leu Met Leu Pro Gly Val Phe 
        195                 200                 205             

Ser Leu Phe Tyr Ser Asp Lys Leu Ser Arg Val Ile Lys Arg Thr Ile 
    210                 215                 220                 

Phe Trp Val Met Leu Phe Tyr Leu Ile Leu Ile Met Ile Leu Thr Gly 
225                 230                 235                 240 

Ser Arg Lys Ile Gln Val Phe Ser Ile Leu Ala Leu Val Leu Val Tyr 
                245                 250                 255     

Thr Gln Ser Leu Gly Ile Thr Phe Ser Lys Lys Arg Val Leu Val Phe 
            260                 265                 270         

Leu Ile Val Thr Val Phe Leu Leu Asn Val Leu Val Val Ile Arg Gly 
        275                 280                 285             

His Arg Phe Asp Leu Asn Thr Ile Gly Ile Tyr Leu Phe Asp Ser Phe 
    290                 295                 300                 

Ser Ser Leu Asp Phe Val Lys Asn Ile Leu Gly Glu Val Phe Ser Glu 
305                 310                 315                 320 

Ser Gly Leu Thr Ser Leu Thr Val Ala Ser Ala Val Thr Val Val Pro 
                325                 330                 335     

Ser Ser Ile Pro Tyr Glu Tyr Gly Met Thr Phe Leu Arg Thr Ile Leu 
            340                 345                 350         

Ser Ile Phe Pro Ile Gly Trp Leu Val Gly Asp Phe Phe Asp Lys Ala 
        355                 360                 365             

Ser Ala Thr Val Val Ile Asn Lys Phe Leu Gly Leu Pro Val Gly Ser 
    370                 375                 380                 

Ser Phe Val Glu Glu Leu Phe Trp Asn Phe Gly Tyr Tyr Gly Gly Val 
385                 390                 395                 400 

Phe Trp Ser Phe Val Leu Gly Ile Phe Ser Gly Trp Arg Leu Asn Phe 
                405                 410                 415     

Arg Ala Phe Gln Thr Ser Lys Ile Ser Lys Val Ile Tyr Phe Ser Val 
            420                 425                 430         

Ile Ser Gln Leu Leu Leu Leu Val Arg Ser Ser Ser Ile Asp Val Tyr 
        435                 440                 445             

Arg Pro Ile Met Tyr Ser Leu Ile Met Ile Phe Ile Phe Arg Arg Leu 
    450                 455                 460                 

Lys Lys 
465     

<210>   541
<211>   1080
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   541
gtggtgaaaa aaattatgtt acatggtgca acggattatg gttcaagtaa ttacggtgat   60
tatctttacg gtgagattgt ctatgattta ttagaatcta aaggatatga agtttctttt   120
tataatccat cagatttctt tcaaatgtac ttgaaagaat atcgccaaaa acaaagtttt   180
actaaaaaac aagcagatgc tattttgtat atcccgggag gatattttgg ggaagggcat   240
aatgcacgtt ttcgtgataa tttaatccaa tttaaacgat ttttaccttt gggaatttgg   300
gcttcatatt ttaaaaagcc tataggagta ttaggtattg gtgcagggcc taataacgat   360
tctttgatga attatggtat aaagagaatt attaatcatg ctcaatttat tacagttcgt   420
gatcgagaat catttgattc tttgaagcat ttgtcgcctt cggctccagt gcatgaaacc   480
tttgatttaa ttatttcaag taaattaaga gaagaaaaaa cagagcagct gtgtcaattg   540
aaaagagaag ctaaagataa gaagataatt cttgttcact ataatcattc caaaaaagct   600
cttgaaaaat ttgcggaatc aattagtctt tttctagaaa acaatcctaa ctattatgtt   660
gtagtaactt cggattccat tctaccttat gaagatgctt attatcagga atttagaaaa   720
ttagttagaa ctgaggattg ttttcaattc aagtatcatt ctcctgcaga aatgacatca   780
ttgttgaaaa tggtagatgt ggttttaact tgtaaattac atgttggggt agtggcaaca   840
tgttttaata aatctgtgat tgccattgca tgccatccag aaaaaacagc acgttattat   900
ggagcaattg gagagttaca acgttgtgaa tctttatttg attcaagtgt taatagtatt   960
gtaaagaaac ttgaaacttt tcatctaaaa ccgataacaa taccttcaga attggtgttg   1020
aaagcgagaa gtagtttgga ctatttagat ctttttttgg aaggactagt tcgtgaaagt   1080

<210>   542
<211>   360
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   542
Met Val Lys Lys Ile Met Leu His Gly Ala Thr Asp Tyr Gly Ser Ser 
1               5                   10                  15      

Asn Tyr Gly Asp Tyr Leu Tyr Gly Glu Ile Val Tyr Asp Leu Leu Glu 
            20                  25                  30          

Ser Lys Gly Tyr Glu Val Ser Phe Tyr Asn Pro Ser Asp Phe Phe Gln 
        35                  40                  45              

Met Tyr Leu Lys Glu Tyr Arg Gln Lys Gln Ser Phe Thr Lys Lys Gln 
    50                  55                  60                  

Ala Asp Ala Ile Leu Tyr Ile Pro Gly Gly Tyr Phe Gly Glu Gly His 
65                  70                  75                  80  

Asn Ala Arg Phe Arg Asp Asn Leu Ile Gln Phe Lys Arg Phe Leu Pro 
                85                  90                  95      

Leu Gly Ile Trp Ala Ser Tyr Phe Lys Lys Pro Ile Gly Val Leu Gly 
            100                 105                 110         

Ile Gly Ala Gly Pro Asn Asn Asp Ser Leu Met Asn Tyr Gly Ile Lys 
        115                 120                 125             

Arg Ile Ile Asn His Ala Gln Phe Ile Thr Val Arg Asp Arg Glu Ser 
    130                 135                 140                 

Phe Asp Ser Leu Lys His Leu Ser Pro Ser Ala Pro Val His Glu Thr 
145                 150                 155                 160 

Phe Asp Leu Ile Ile Ser Ser Lys Leu Arg Glu Glu Lys Thr Glu Gln 
                165                 170                 175     

Leu Cys Gln Leu Lys Arg Glu Ala Lys Asp Lys Lys Ile Ile Leu Val 

            180                 185                 190         

His Tyr Asn His Ser Lys Lys Ala Leu Glu Lys Phe Ala Glu Ser Ile 
        195                 200                 205             

Ser Leu Phe Leu Glu Asn Asn Pro Asn Tyr Tyr Val Val Val Thr Ser 
    210                 215                 220                 

Asp Ser Ile Leu Pro Tyr Glu Asp Ala Tyr Tyr Gln Glu Phe Arg Lys 
225                 230                 235                 240 

Leu Val Arg Thr Glu Asp Cys Phe Gln Phe Lys Tyr His Ser Pro Ala 
                245                 250                 255     

Glu Met Thr Ser Leu Leu Lys Met Val Asp Val Val Leu Thr Cys Lys 
            260                 265                 270         

Leu His Val Gly Val Val Ala Thr Cys Phe Asn Lys Ser Val Ile Ala 
        275                 280                 285             

Ile Ala Cys His Pro Glu Lys Thr Ala Arg Tyr Tyr Gly Ala Ile Gly 
    290                 295                 300                 

Glu Leu Gln Arg Cys Glu Ser Leu Phe Asp Ser Ser Val Asn Ser Ile 
305                 310                 315                 320 

Val Lys Lys Leu Glu Thr Phe His Leu Lys Pro Ile Thr Ile Pro Ser 
                325                 330                 335     

Glu Leu Val Leu Lys Ala Arg Ser Ser Leu Asp Tyr Leu Asp Leu Phe 
            340                 345                 350         

Leu Glu Gly Leu Val Arg Glu Ser 
        355                 360 

<210>   543
<211>   1239
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   543
gtgaaagttg atagaatttc atttataaaa aatacaagtt ctctctatat tctgaatatt   60
gttaaattac tatttccttt attaacactc ccgtatttga caagggtgct ttcgctagac   120
gcgtatggaa tggttattta tgttaaagcg ttaatagctt atgttcaact ggtgattgat   180
tttggtttca tgatatcagc tacaaaaaat attgtaaatg cttgtactac tccctcaaag   240
attggaagga tagttggaga tactctagtt gaaaaaatat ttttatctat catttcgatt   300
ctaatttaca ccatattgat gtggcaaatc ccaataatga gagagaatat tcttttttca   360
gttttttatt tgttagctac agtgaccaat atttttatct ttgacttttt atttcgtgga   420
attgaaaaga tgcatgcagt tgcaattcct tatattattt ctaaaactat cattacaatt   480
ttgacattta ttgtagtaaa agatgattct tctattttat ggattcctat attggaagga   540
attgggaatt tagttgctgc agtagtttct tatagattcc ttcattatta tggaattaaa   600
ttatcatttt cttatctgtc tgtttgggtt aaagatttaa aggaatcctc tatttatttt   660
ttatccaatt ttgcaactac tatttttggc gtctttacga cagtcatttc gggtttttat   720
ttacaaagtc aagagatagc cttttggggg atagcaatgc aactgctttc agcagcaaaa   780
tcattgtata atcctatagc gaatagttta tatccgcata tgatacgtac taaagatata   840
caatcggtta agagtattaa tcggattatg tttattccta ttatctttgg agttttgata   900
gttttattct tttcaaatca aattctttct ataattggtg gtgaaaaata taccgtttca   960
gcagattttc ttaagtactt attacccgct tttgttgcta gtttttattc tatgatttac   1020
ggatggcctg tcttaggagc tattgataaa gtgaaagaaa ctacaatgac aactatatta   1080
gcttcgattg tccaaacttt gggattagga atatttatct tgtctgataa ttttagttta   1140
gtaacattag ctatttgttc aagtatgtct gaggtggtgt tatggattag ccgttatcta   1200
atttatttta agaaccgttc attatttgtt aggagtaag                          1239

<210>   544
<211>   413
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   O-antigen transporter RfbX, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902361 (9.E-11)

<400>   544
Met Lys Val Asp Arg Ile Ser Phe Ile Lys Asn Thr Ser Ser Leu Tyr 
1               5                   10                  15      

Ile Leu Asn Ile Val Lys Leu Leu Phe Pro Leu Leu Thr Leu Pro Tyr 
            20                  25                  30          

Leu Thr Arg Val Leu Ser Leu Asp Ala Tyr Gly Met Val Ile Tyr Val 
        35                  40                  45              

Lys Ala Leu Ile Ala Tyr Val Gln Leu Val Ile Asp Phe Gly Phe Met 
    50                  55                  60                  

Ile Ser Ala Thr Lys Asn Ile Val Asn Ala Cys Thr Thr Pro Ser Lys 
65                  70                  75                  80  

Ile Gly Arg Ile Val Gly Asp Thr Leu Val Glu Lys Ile Phe Leu Ser 
                85                  90                  95      

Ile Ile Ser Ile Leu Ile Tyr Thr Ile Leu Met Trp Gln Ile Pro Ile 
            100                 105                 110         

Met Arg Glu Asn Ile Leu Phe Ser Val Phe Tyr Leu Leu Ala Thr Val 
        115                 120                 125             

Thr Asn Ile Phe Ile Phe Asp Phe Leu Phe Arg Gly Ile Glu Lys Met 
    130                 135                 140                 

His Ala Val Ala Ile Pro Tyr Ile Ile Ser Lys Thr Ile Ile Thr Ile 
145                 150                 155                 160 

Leu Thr Phe Ile Val Val Lys Asp Asp Ser Ser Ile Leu Trp Ile Pro 
                165                 170                 175     

Ile Leu Glu Gly Ile Gly Asn Leu Val Ala Ala Val Val Ser Tyr Arg 
            180                 185                 190         

Phe Leu His Tyr Tyr Gly Ile Lys Leu Ser Phe Ser Tyr Leu Ser Val 
        195                 200                 205             

Trp Val Lys Asp Leu Lys Glu Ser Ser Ile Tyr Phe Leu Ser Asn Phe 
    210                 215                 220                 

Ala Thr Thr Ile Phe Gly Val Phe Thr Thr Val Ile Ser Gly Phe Tyr 
225                 230                 235                 240 

Leu Gln Ser Gln Glu Ile Ala Phe Trp Gly Ile Ala Met Gln Leu Leu 
                245                 250                 255     

Ser Ala Ala Lys Ser Leu Tyr Asn Pro Ile Ala Asn Ser Leu Tyr Pro 
            260                 265                 270         

His Met Ile Arg Thr Lys Asp Ile Gln Ser Val Lys Ser Ile Asn Arg 
        275                 280                 285             

Ile Met Phe Ile Pro Ile Ile Phe Gly Val Leu Ile Val Leu Phe Phe 
    290                 295                 300                 

Ser Asn Gln Ile Leu Ser Ile Ile Gly Gly Glu Lys Tyr Thr Val Ser 
305                 310                 315                 320 

Ala Asp Phe Leu Lys Tyr Leu Leu Pro Ala Phe Val Ala Ser Phe Tyr 
                325                 330                 335     

Ser Met Ile Tyr Gly Trp Pro Val Leu Gly Ala Ile Asp Lys Val Lys 
            340                 345                 350         

Glu Thr Thr Met Thr Thr Ile Leu Ala Ser Ile Val Gln Thr Leu Gly 
        355                 360                 365             

Leu Gly Ile Phe Ile Leu Ser Asp Asn Phe Ser Leu Val Thr Leu Ala 
    370                 375                 380                 

Ile Cys Ser Ser Met Ser Glu Val Val Leu Trp Ile Ser Arg Tyr Leu 
385                 390                 395                 400 

Ile Tyr Phe Lys Asn Arg Ser Leu Phe Val Arg Ser Lys 
                405                 410             

<210>   545
<211>   1116
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   545
ttgttaggag taagtaaata tatgaaaaaa gtagttgtag tatttggaac tcgtccagaa   60
gccatcaaga tgtgtccttt ggtcaaagag ttaagaacac gtaagaatat tgaaacatta   120
gtttgcgtta cgggccaaca ccgtcaaatg ttggatcagg tcttggacac atttgggatt   180
attcccgatt ttgatttgtc tattatgaaa gataaacaaa ctttatttga tgtgaccatt   240
ggcattttgg aaggaatgaa ggctatttta gagtcagaaa aacctgattt ggtgttagtt   300
catggggata caagtacgac cttcgctagt tcactggcgg ccttttattt acagattcca   360
attggtcatg ttgaagctgg tttgcgcact tacgatatct attcaccata tcctgaagag   420
tttaatcgtc aagcagttgg ggttttggct cagtatcatt ttacaccaac acaactttca   480
aaagataatc ttttaagaga aggaaaaact ccagagagca tatttgtgac aggtaatacg   540
gcgattgatg ctttacaaac tacaattcaa gaggactata cgcatcctga gttagaatgg   600
ataggagaaa gcaggtttat tctaattaca gctcatcgtc gtgaaaatct tggtgaaccg   660
atgagacata tgtttagagc aattagaagg attattgaag aatattcaga tgtcaaggct   720
atttatccta tccatatgaa tcctcgtgtt cgccaaattg ctgaggaaga actaagtggc   780
tgtgaacgta tcaagatgat cgaaccttta gaagtattag attttcacaa ttttttatca   840
agaagttatt taattttaac agatagtggt ggtattcagg aagaggctcc aagtttagga   900
aaacctgttt tggttatgag agatacaact gaacgtccag agggaattga agcagggact   960
ttgaaacttg taggtgctga tgaaaataat atttataggc attttaaaga attattagaa   1020
aatgattcag tttatcaagc aatgagtcaa gcttcaaatc catatggaga tggaacggct   1080
tgtaagaaaa ttgcagacat actagaagga gaagtg                             1116

<210>   546
<211>   372
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylglucosamine-2-epimerase (cps4I)
<223>   Cellular location: cytoplasm

<400>   546
Met Leu Gly Val Ser Lys Tyr Met Lys Lys Val Val Val Val Phe Gly 
1               5                   10                  15      

Thr Arg Pro Glu Ala Ile Lys Met Cys Pro Leu Val Lys Glu Leu Arg 
            20                  25                  30          

Thr Arg Lys Asn Ile Glu Thr Leu Val Cys Val Thr Gly Gln His Arg 
        35                  40                  45              

Gln Met Leu Asp Gln Val Leu Asp Thr Phe Gly Ile Ile Pro Asp Phe 
    50                  55                  60                  

Asp Leu Ser Ile Met Lys Asp Lys Gln Thr Leu Phe Asp Val Thr Ile 
65                  70                  75                  80  

Gly Ile Leu Glu Gly Met Lys Ala Ile Leu Glu Ser Glu Lys Pro Asp 
                85                  90                  95      

Leu Val Leu Val His Gly Asp Thr Ser Thr Thr Phe Ala Ser Ser Leu 
            100                 105                 110         

Ala Ala Phe Tyr Leu Gln Ile Pro Ile Gly His Val Glu Ala Gly Leu 
        115                 120                 125             

Arg Thr Tyr Asp Ile Tyr Ser Pro Tyr Pro Glu Glu Phe Asn Arg Gln 
    130                 135                 140                 

Ala Val Gly Val Leu Ala Gln Tyr His Phe Thr Pro Thr Gln Leu Ser 
145                 150                 155                 160 

Lys Asp Asn Leu Leu Arg Glu Gly Lys Thr Pro Glu Ser Ile Phe Val 
                165                 170                 175     

Thr Gly Asn Thr Ala Ile Asp Ala Leu Gln Thr Thr Ile Gln Glu Asp 
            180                 185                 190         

Tyr Thr His Pro Glu Leu Glu Trp Ile Gly Glu Ser Arg Phe Ile Leu 
        195                 200                 205             

Ile Thr Ala His Arg Arg Glu Asn Leu Gly Glu Pro Met Arg His Met 
    210                 215                 220                 

Phe Arg Ala Ile Arg Arg Ile Ile Glu Glu Tyr Ser Asp Val Lys Ala 
225                 230                 235                 240 

Ile Tyr Pro Ile His Met Asn Pro Arg Val Arg Gln Ile Ala Glu Glu 
                245                 250                 255     

Glu Leu Ser Gly Cys Glu Arg Ile Lys Met Ile Glu Pro Leu Glu Val 
            260                 265                 270         

Leu Asp Phe His Asn Phe Leu Ser Arg Ser Tyr Leu Ile Leu Thr Asp 
        275                 280                 285             

Ser Gly Gly Ile Gln Glu Glu Ala Pro Ser Leu Gly Lys Pro Val Leu 
    290                 295                 300                 

Val Met Arg Asp Thr Thr Glu Arg Pro Glu Gly Ile Glu Ala Gly Thr 
305                 310                 315                 320 

Leu Lys Leu Val Gly Ala Asp Glu Asn Asn Ile Tyr Arg His Phe Lys 
                325                 330                 335     

Glu Leu Leu Glu Asn Asp Ser Val Tyr Gln Ala Met Ser Gln Ala Ser 
            340                 345                 350         

Asn Pro Tyr Gly Asp Gly Thr Ala Cys Lys Lys Ile Ala Asp Ile Leu 
        355                 360                 365             

Glu Gly Glu Val 
    370         

<210>   547
<211>   1053
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   547
atgtcacaat ttacaggaaa aactctccta attacaggag ggacaggttc atttgggaat   60
gcggttctca agcgtttttt agaaacagat gtctcagaga ttcgtatatt ttcgcgagat   120
gaaaagaaac aagatgatat gcgtcatgag tttcaggtaa aagtaccaga agtggctggg   180
aaaatccgtt tttaccttgg agatgtgcgt gacttagctt cggtaaaaaa tgctatgcat   240
ggtgtggatt atgtttttca cgctgctgct cttaaacaag taccttcttg tgaatttttc   300
cctgtagaag cggtaaaaac taacattttg ggaacggaga atgtcctcac tgcggctatc   360
gaagctggtg taaagcaagt tatctgtctt tctacagata aggcggctta tcctgtcaat   420
gctatgggaa catccaaggc tatgatggaa aagattgctg ttgctaagtc caggacggta   480
aatcctgagc atacaaagat atgtgtgact cgctatggga atgttctgtg tagccgtgga   540
tctgtcgttc ctctttggat tgagcaaatt aagcaaggaa atgctcttac aattactgaa   600
cctagcatga cacgttttgt gatgacattg gaagaagcag tagacttggt tttatttgca   660
tttgaagaag ggaaatctgg agatatacta gttcagaaag caccagcatg tacgattgaa   720
gtgttggcta aggctgtatc agaaattttt gcctcagaac aagatattaa gattataggt   780
attagacacg gagaaaaaag gtatgaaaca ctattaacta acgaagagtg cgcaaatgca   840
attgatttgg gtgattttta tagagttcct agtgataatc gtaatcttaa ctatgataag   900
tatttcaaag atggtagtac gaatagaaat ttgttgacag aattcaatag taataatacc   960
gatttgatgg atgtagagca agttaaaaga aagttgctag aattagatga aatacagaca   1020
gcaattcgtg atatggtagc agacgaagag atg                                1053

<210>   548
<211>   351
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein cps4J (cap4J)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902136 (2.E-36)

<400>   548
Met Ser Gln Phe Thr Gly Lys Thr Leu Leu Ile Thr Gly Gly Thr Gly 
1               5                   10                  15      

Ser Phe Gly Asn Ala Val Leu Lys Arg Phe Leu Glu Thr Asp Val Ser 
            20                  25                  30          

Glu Ile Arg Ile Phe Ser Arg Asp Glu Lys Lys Gln Asp Asp Met Arg 
        35                  40                  45              

His Glu Phe Gln Val Lys Val Pro Glu Val Ala Gly Lys Ile Arg Phe 
    50                  55                  60                  

Tyr Leu Gly Asp Val Arg Asp Leu Ala Ser Val Lys Asn Ala Met His 
65                  70                  75                  80  

Gly Val Asp Tyr Val Phe His Ala Ala Ala Leu Lys Gln Val Pro Ser 
                85                  90                  95      

Cys Glu Phe Phe Pro Val Glu Ala Val Lys Thr Asn Ile Leu Gly Thr 
            100                 105                 110         

Glu Asn Val Leu Thr Ala Ala Ile Glu Ala Gly Val Lys Gln Val Ile 
        115                 120                 125             

Cys Leu Ser Thr Asp Lys Ala Ala Tyr Pro Val Asn Ala Met Gly Thr 
    130                 135                 140                 

Ser Lys Ala Met Met Glu Lys Ile Ala Val Ala Lys Ser Arg Thr Val 
145                 150                 155                 160 

Asn Pro Glu His Thr Lys Ile Cys Val Thr Arg Tyr Gly Asn Val Leu 
                165                 170                 175     

Cys Ser Arg Gly Ser Val Val Pro Leu Trp Ile Glu Gln Ile Lys Gln 
            180                 185                 190         

Gly Asn Ala Leu Thr Ile Thr Glu Pro Ser Met Thr Arg Phe Val Met 
        195                 200                 205             

Thr Leu Glu Glu Ala Val Asp Leu Val Leu Phe Ala Phe Glu Glu Gly 
    210                 215                 220                 

Lys Ser Gly Asp Ile Leu Val Gln Lys Ala Pro Ala Cys Thr Ile Glu 
225                 230                 235                 240 

Val Leu Ala Lys Ala Val Ser Glu Ile Phe Ala Ser Glu Gln Asp Ile 
                245                 250                 255     

Lys Ile Ile Gly Ile Arg His Gly Glu Lys Arg Tyr Glu Thr Leu Leu 
            260                 265                 270         

Thr Asn Glu Glu Cys Ala Asn Ala Ile Asp Leu Gly Asp Phe Tyr Arg 
        275                 280                 285             

Val Pro Ser Asp Asn Arg Asn Leu Asn Tyr Asp Lys Tyr Phe Lys Asp 
    290                 295                 300                 

Gly Ser Thr Asn Arg Asn Leu Leu Thr Glu Phe Asn Ser Asn Asn Thr 
305                 310                 315                 320 

Asp Leu Met Asp Val Glu Gln Val Lys Arg Lys Leu Leu Glu Leu Asp 
                325                 330                 335     

Glu Ile Gln Thr Ala Ile Arg Asp Met Val Ala Asp Glu Glu Met 
            340                 345                 350     

<210>   549
<211>   1227
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   549
atgattaaaa atattttaat cacaggagcg aaaggatttg taggaaaaaa tcttatctgt   60
actctggaag ctttgaaaga tggacgagat aggactcgtc ctaatttaga gattggagag   120
atttttcagt atgatcgtga tacagatccg attttattag atgaatattg taagaaggcc   180
gatttcgtat tccatttagc tggtgtcaat cgtccacaga atcctgatga attcatggag   240
ggaaattacg gtttttcaag tagattattg gagattttag aaaagtatga aaacacttgt   300
cctgttctac tctcaagttc tactcaagct agtttagaag gccgattttc aaactctata   360
tatggacaat ctaagctagc aggggaagaa ctcttctttg aatatggaaa gaaaacggga   420
gcacctgtct tagtttaccg tttcccgaat ctttatggga agtggtgccg tcctaactac   480
aattctgctg tagcaacttt ctgttataat ctagctcacg atttacctat tcaagtaaat   540
gatccaagtg tagaattgga gttgctgtat attgatgatt tgatacaaga gtgtctaact   600
gcattggaag gaaatcctca tcgttgtaat ctagatggat tacaaatctt acctagccca   660
tcaggaaact actgctacgt accaacgact catcgtgcaa ccttaggaga gattgtctct   720
ctattagaaa catttaaaaa acagcctgat agtttagtta tgcctgaaat tcctcaggga   780
tcgtttaaaa agaaattgta ttctacctac ctatcttatt taccagtaga taagtttaag   840
tttcctctaa aaatgaatat agatgaacga ggtagtttta cggaattatt aaaaacagaa   900
aatacgggtc aattttctgt taatatttct aaacctggca ttaccaaagg gcaacattgg   960
catcattcta agtgggaatt tttcatggtt gtttctggtc gtgctttaat acaagagcgt   1020
aggatagggc tggatgaaaa cggtcaagag tatcctattc tgaactttga agtgtcgggc   1080
gataagattg aagcaataca tatgataccg ggctatgcac ataatattat taatctttct   1140
gatacagaaa atctaattac tgtcatgtgg gctaatgagt catttgatcc tagacatcca   1200
gatacttttt ttgaacaagt ggagaaa                                       1227

<210>   550
<211>   409
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein Cps4K (cps4K)
<223>   Cellular location: cytoplasm

<400>   550
Met Ile Lys Asn Ile Leu Ile Thr Gly Ala Lys Gly Phe Val Gly Lys 
1               5                   10                  15      

Asn Leu Ile Cys Thr Leu Glu Ala Leu Lys Asp Gly Arg Asp Arg Thr 
            20                  25                  30          

Arg Pro Asn Leu Glu Ile Gly Glu Ile Phe Gln Tyr Asp Arg Asp Thr 
        35                  40                  45              

Asp Pro Ile Leu Leu Asp Glu Tyr Cys Lys Lys Ala Asp Phe Val Phe 
    50                  55                  60                  

His Leu Ala Gly Val Asn Arg Pro Gln Asn Pro Asp Glu Phe Met Glu 
65                  70                  75                  80  

Gly Asn Tyr Gly Phe Ser Ser Arg Leu Leu Glu Ile Leu Glu Lys Tyr 
                85                  90                  95      

Glu Asn Thr Cys Pro Val Leu Leu Ser Ser Ser Thr Gln Ala Ser Leu 
            100                 105                 110         

Glu Gly Arg Phe Ser Asn Ser Ile Tyr Gly Gln Ser Lys Leu Ala Gly 
        115                 120                 125             

Glu Glu Leu Phe Phe Glu Tyr Gly Lys Lys Thr Gly Ala Pro Val Leu 
    130                 135                 140                 

Val Tyr Arg Phe Pro Asn Leu Tyr Gly Lys Trp Cys Arg Pro Asn Tyr 
145                 150                 155                 160 

Asn Ser Ala Val Ala Thr Phe Cys Tyr Asn Leu Ala His Asp Leu Pro 
                165                 170                 175     

Ile Gln Val Asn Asp Pro Ser Val Glu Leu Glu Leu Leu Tyr Ile Asp 
            180                 185                 190         

Asp Leu Ile Gln Glu Cys Leu Thr Ala Leu Glu Gly Asn Pro His Arg 
        195                 200                 205             

Cys Asn Leu Asp Gly Leu Gln Ile Leu Pro Ser Pro Ser Gly Asn Tyr 
    210                 215                 220                 

Cys Tyr Val Pro Thr Thr His Arg Ala Thr Leu Gly Glu Ile Val Ser 
225                 230                 235                 240 

Leu Leu Glu Thr Phe Lys Lys Gln Pro Asp Ser Leu Val Met Pro Glu 
                245                 250                 255     

Ile Pro Gln Gly Ser Phe Lys Lys Lys Leu Tyr Ser Thr Tyr Leu Ser 
            260                 265                 270         

Tyr Leu Pro Val Asp Lys Phe Lys Phe Pro Leu Lys Met Asn Ile Asp 
        275                 280                 285             

Glu Arg Gly Ser Phe Thr Glu Leu Leu Lys Thr Glu Asn Thr Gly Gln 
    290                 295                 300                 

Phe Ser Val Asn Ile Ser Lys Pro Gly Ile Thr Lys Gly Gln His Trp 
305                 310                 315                 320 

His His Ser Lys Trp Glu Phe Phe Met Val Val Ser Gly Arg Ala Leu 
                325                 330                 335     

Ile Gln Glu Arg Arg Ile Gly Leu Asp Glu Asn Gly Gln Glu Tyr Pro 
            340                 345                 350         

Ile Leu Asn Phe Glu Val Ser Gly Asp Lys Ile Glu Ala Ile His Met 
        355                 360                 365             

Ile Pro Gly Tyr Ala His Asn Ile Ile Asn Leu Ser Asp Thr Glu Asn 
    370                 375                 380                 

Leu Ile Thr Val Met Trp Ala Asn Glu Ser Phe Asp Pro Arg His Pro 
385                 390                 395                 400 

Asp Thr Phe Phe Glu Gln Val Glu Lys 
                405                 

<210>   551
<211>   1182
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   551
atgaaaatta agacagatta tagtgatatt cactttaaag ataatggcaa acttaagtta   60
ttgattattg tgggaacacg tccagagatt atacgtctaa gtagtgttat cactaaatgt   120
cgaaagtatt ttgatgttat tttggcacat actggacaaa actatgatta caatttaaat   180
ggtattttct ttgataattt agggttagac actccggacg tatacatgga tgctgttgga   240
gatgatcttg gtgctactgt agggaatatt attaatactt catacaaatt gatgaatcaa   300
attaaaccag atgctttatt gattttaggg gatacaaatt cttgtttatc agctattgct   360
gccaagcgtt tacatattcc aatttttcat atggaggctg gcaatcgctg taaagatgag   420
tgcctaccgg aagagactaa tcgtcggatt gttgatgtta tttcagatgt taacttagca   480
tactctgaac atgcacgtaa gtatttacat gagtgtggtt tacctaaaga gcgcacatat   540
gtaactggtt ctcctatggc agaagtgtta cataaaaatt tatctgctat tgagtcttca   600
gatatccatg aacgtttggg attgaaaaaa ggaggttata tcttactttc agctcaccgt   660
gaggaaaata ttgatacaga taaaaatttt atttctctct ttacagcaat taatcaatta   720
gctgaaaagt ataatatgcc aatcttatat tcttgccatc ctagatcaaa gaaaaggcta   780
caagagagcg gttttaaact agataaacgt gtgattcagc atgagccact aggattccat   840
gactataatt gtttacagat gaatgcattt gttgtagtat ctgattcggg aactttaccg   900
gaagaaagta gtttctttac tagtcaaggt tatccttttc ccgctgtatg tattcgtaca   960
agtacagaac gtcctgagtc cttagataag gcaggattta ttttggcagg cattgatgaa   1020
aattctcttc ttcaagcagt tgaaactgct gttagcttgg cacaagatga ggattttgga   1080
ttaccggttc cggattatgt tgaggaaaat gtctctacta aagttgttaa gataatacag   1140
agctatacag ggatagtgga taaaatagtt tggaggaaaa gc                      1182

<210>   552
<211>   394
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylglucosamine 2-epimerase (cps4L)
<223>   Cellular location: cytoplasm

<400>   552
Met Lys Ile Lys Thr Asp Tyr Ser Asp Ile His Phe Lys Asp Asn Gly 
1               5                   10                  15      

Lys Leu Lys Leu Leu Ile Ile Val Gly Thr Arg Pro Glu Ile Ile Arg 
            20                  25                  30          

Leu Ser Ser Val Ile Thr Lys Cys Arg Lys Tyr Phe Asp Val Ile Leu 
        35                  40                  45              

Ala His Thr Gly Gln Asn Tyr Asp Tyr Asn Leu Asn Gly Ile Phe Phe 
    50                  55                  60                  

Asp Asn Leu Gly Leu Asp Thr Pro Asp Val Tyr Met Asp Ala Val Gly 
65                  70                  75                  80  

Asp Asp Leu Gly Ala Thr Val Gly Asn Ile Ile Asn Thr Ser Tyr Lys 
                85                  90                  95      

Leu Met Asn Gln Ile Lys Pro Asp Ala Leu Leu Ile Leu Gly Asp Thr 
            100                 105                 110         

Asn Ser Cys Leu Ser Ala Ile Ala Ala Lys Arg Leu His Ile Pro Ile 
        115                 120                 125             

Phe His Met Glu Ala Gly Asn Arg Cys Lys Asp Glu Cys Leu Pro Glu 
    130                 135                 140                 

Glu Thr Asn Arg Arg Ile Val Asp Val Ile Ser Asp Val Asn Leu Ala 
145                 150                 155                 160 

Tyr Ser Glu His Ala Arg Lys Tyr Leu His Glu Cys Gly Leu Pro Lys 
                165                 170                 175     

Glu Arg Thr Tyr Val Thr Gly Ser Pro Met Ala Glu Val Leu His Lys 
            180                 185                 190         

Asn Leu Ser Ala Ile Glu Ser Ser Asp Ile His Glu Arg Leu Gly Leu 
        195                 200                 205             

Lys Lys Gly Gly Tyr Ile Leu Leu Ser Ala His Arg Glu Glu Asn Ile 
    210                 215                 220                 

Asp Thr Asp Lys Asn Phe Ile Ser Leu Phe Thr Ala Ile Asn Gln Leu 
225                 230                 235                 240 

Ala Glu Lys Tyr Asn Met Pro Ile Leu Tyr Ser Cys His Pro Arg Ser 
                245                 250                 255     

Lys Lys Arg Leu Gln Glu Ser Gly Phe Lys Leu Asp Lys Arg Val Ile 
            260                 265                 270         

Gln His Glu Pro Leu Gly Phe His Asp Tyr Asn Cys Leu Gln Met Asn 
        275                 280                 285             

Ala Phe Val Val Val Ser Asp Ser Gly Thr Leu Pro Glu Glu Ser Ser 
    290                 295                 300                 

Phe Phe Thr Ser Gln Gly Tyr Pro Phe Pro Ala Val Cys Ile Arg Thr 
305                 310                 315                 320 

Ser Thr Glu Arg Pro Glu Ser Leu Asp Lys Ala Gly Phe Ile Leu Ala 
                325                 330                 335     

Gly Ile Asp Glu Asn Ser Leu Leu Gln Ala Val Glu Thr Ala Val Ser 
            340                 345                 350         

Leu Ala Gln Asp Glu Asp Phe Gly Leu Pro Val Pro Asp Tyr Val Glu 
        355                 360                 365             

Glu Asn Val Ser Thr Lys Val Val Lys Ile Ile Gln Ser Tyr Thr Gly 
    370                 375                 380                 

Ile Val Asp Lys Ile Val Trp Arg Lys Ser 
385                 390                 

<210>   553
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   553
ttgggcggtt actttcgaaa ctttgaaaac ttcaaaaaac ggatttttat cgctctgaac   60
atcaaaaaag aaaggacgaa atttgtcctt tctcaagct                          99

<210>   554
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase, truncation

<400>   554
Met Gly Gly Tyr Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile Phe 
1               5                   10                  15      

Ile Ala Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser Gln 
            20                  25                  30          

Ala 
    

<210>   555
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   555
ttggtaaact gcgaacagct agaagcttat cgtcaactgg aagaagctgc acttgttgga   60
tgttgggcgc atgtgagaag gaagtttttt gaagtgcccc ccaagcaagc agataaatca   120
tccttaggag ctaaaggttt agcctattgt gatcagttat tttccttgga aagagactgg   180
gaggctttgc cagctgatga acggctacag aaacgtcaag aacatctcca acccctactg   240
gaagacttct ttgcttggtg ccgtcgtcag tcagttttat cgggttcaaa actaggaagg   300
gcaattgaat acagcctcaa gtatgaagaa acctttaaga ccattttaaa agacggacat   360
ctggtccttt ccaataatct agctgaacgc gccattaaat cattggttat gggacggagt   420
aaaagagtcc agtggactct tttagcc                                       447

<210>   556
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein

<400>   556
Met Val Asn Cys Glu Gln Leu Glu Ala Tyr Arg Gln Leu Glu Glu Ala 
1               5                   10                  15      

Ala Leu Val Gly Cys Trp Ala His Val Arg Arg Lys Phe Phe Glu Val 
            20                  25                  30          

Pro Pro Lys Gln Ala Asp Lys Ser Ser Leu Gly Ala Lys Gly Leu Ala 
        35                  40                  45              

Tyr Cys Asp Gln Leu Phe Ser Leu Glu Arg Asp Trp Glu Ala Leu Pro 
    50                  55                  60                  

Ala Asp Glu Arg Leu Gln Lys Arg Gln Glu His Leu Gln Pro Leu Leu 
65                  70                  75                  80  

Glu Asp Phe Phe Ala Trp Cys Arg Arg Gln Ser Val Leu Ser Gly Ser 
                85                  90                  95      

Lys Leu Gly Arg Ala Ile Glu Tyr Ser Leu Lys Tyr Glu Glu Thr Phe 
            100                 105                 110         

Lys Thr Ile Leu Lys Asp Gly His Leu Val Leu Ser Asn Asn Leu Ala 
        115                 120                 125             

Glu Arg Ala Ile Lys Ser Leu Val Met Gly Arg Ser Lys Arg Val Gln 
    130                 135                 140                 

Trp Thr Leu Leu Ala 
145                 

<210>   557
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   557
ttgcgagaga gactattgac tcagccctta cttcatgcgg atgaaacctc ctatcgggtt   60
ctagagagtg atagccatct gacctactat tggacttttt tgtcaggtaa agcagagaaa   120
caagggatta cgctttacca ccatgatcag tgtcgaagtg gttcagtagt acaagaattc   180
ctaggagatt attctggcta tgttcattgt gatatgttgc ggcag                   225

<210>   558
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf3, degenerate

<400>   558
Met Arg Glu Arg Leu Leu Thr Gln Pro Leu Leu His Ala Asp Glu Thr 
1               5                   10                  15      

Ser Tyr Arg Val Leu Glu Ser Asp Ser His Leu Thr Tyr Tyr Trp Thr 
            20                  25                  30          

Phe Leu Ser Gly Lys Ala Glu Lys Gln Gly Ile Thr Leu Tyr His His 
        35                  40                  45              

Asp Gln Cys Arg Ser Gly Ser Val Val Gln Glu Phe Leu Gly Asp Tyr 
    50                  55                  60                  

Ser Gly Tyr Val His Cys Asp Met Leu Arg Gln 
65                  70                  75  

<210>   559
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   559
atggacaatg ctatatggca taaatcaagt accttaaaga ttccgactaa tattggcttt   60
gcatttattc ctccatacac accagagatg aaccccattg aacaagtgtg gaaagagatt   120
cgtaaacgtg gatttaagaa taaagccttt cgaactttgg aagatgtcat gaatcaactt   180
caagatgtta tacaaggact ggagaaggag gtgataaagt ccatcgttaa tcggagatgg   240
actagagtgc tttttgaaag caga                                          264

<210>   560
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase family protein, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903763 (3.E-11)

<400>   560
Met Asp Asn Ala Ile Trp His Lys Ser Ser Thr Leu Lys Ile Pro Thr 
1               5                   10                  15      

Asn Ile Gly Phe Ala Phe Ile Pro Pro Tyr Thr Pro Glu Met Asn Pro 
            20                  25                  30          

Ile Glu Gln Val Trp Lys Glu Ile Arg Lys Arg Gly Phe Lys Asn Lys 
        35                  40                  45              

Ala Phe Arg Thr Leu Glu Asp Val Met Asn Gln Leu Gln Asp Val Ile 
    50                  55                  60                  

Gln Gly Leu Glu Lys Glu Val Ile Lys Ser Ile Val Asn Arg Arg Trp 
65                  70                  75                  80  

Thr Arg Val Leu Phe Glu Ser Arg 
                85              

<210>   561
<211>   321
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   561
atgacaattc atctatctag cctagggcag gtctatctcg tgtgtgggaa aactgatatg   60
agacaaggaa tcgattcact ggcttatctc gttaaaaccc actttgaatt ggatcctttc   120
tccggtcaaa tctttctctt ttgtggtgga cgtaaagacc gctttaaagt cctttactgg   180
gatggtcaag gattttggct actatataaa cgctttgaga acggcagact gacttggccc   240
agtacagaaa aggatgtcaa agctctcgca cctgaacaag tagattggct gatgaaaggc   300
ttttctatca ctccaaaaat a                                             321

<210>   562
<211>   107
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf2, interruption
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903342 (1.E-38)

<400>   562
Met Thr Ile His Leu Ser Ser Leu Gly Gln Val Tyr Leu Val Cys Gly 
1               5                   10                  15      

Lys Thr Asp Met Arg Gln Gly Ile Asp Ser Leu Ala Tyr Leu Val Lys 
            20                  25                  30          

Thr His Phe Glu Leu Asp Pro Phe Ser Gly Gln Ile Phe Leu Phe Cys 
        35                  40                  45              

Gly Gly Arg Lys Asp Arg Phe Lys Val Leu Tyr Trp Asp Gly Gln Gly 
    50                  55                  60                  

Phe Trp Leu Leu Tyr Lys Arg Phe Glu Asn Gly Arg Leu Thr Trp Pro 
65                  70                  75                  80  

Ser Thr Glu Lys Asp Val Lys Ala Leu Ala Pro Glu Gln Val Asp Trp 
                85                  90                  95      

Leu Met Lys Gly Phe Ser Ile Thr Pro Lys Ile 
            100                 105         

<210>   563
<211>   198
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   563
ttggaggata ttttaatgcc acaacctatt gttcctgtag agattccaca atctcgtcgt   60
tttgattcta aaaagagaaa tgatattcta cttaaaattc gtattggcaa gcttgaagta   120
agtttttttc aatctctcaa tctcgaaatg atagaacagc ttttggataa ggtgttgctc   180
tatgacaatt catctatc                                                 198

<210>   564
<211>   66
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf1
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903763 (0.E+01)

<400>   564
Met Glu Asp Ile Leu Met Pro Gln Pro Ile Val Pro Val Glu Ile Pro 
1               5                   10                  15      

Gln Ser Arg Arg Phe Asp Ser Lys Lys Arg Asn Asp Ile Leu Leu Lys 
            20                  25                  30          

Ile Arg Ile Gly Lys Leu Glu Val Ser Phe Phe Gln Ser Leu Asn Leu 
        35                  40                  45              

Glu Met Ile Glu Gln Leu Leu Asp Lys Val Leu Leu Tyr Asp Asn Ser 
    50                  55                  60                  

Ser Ile 
65      

<210>   565
<211>   1982
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   565
atgatgaaaa gttcaaaact atttgccctt gcgggcgtga cattattggc ggcgactact   60
ttagctgcat gctctggatc aggttcaagc actaaaggtg agaagacatt ctcatacatt   120
tatgagacag accctgataa cctcaactat ttgacaactg ctaaggctgc gacacaaata   180
ttaccagtaa cgtggttgat ggtttgctag aaaatgatcg ctacgggaac tttgtgccgt   240
ctatggctga ggattggtct gtatccaagg atggattgac ttacacttat actatccgta   300
aggatgcaaa atggtatact tctgaaggtg aagaatacgc ggcagtcaaa gctcaagact   360
ttgtaacagg attaaaatat gctgctgata aaaaatcaga tgctctttac cttgttcaag   420
aatcaatcaa agggttggat gcctatgtaa aaggggaaat caaagatttc tcacaagtag   480
gaattaaggc tctggatgaa cagacagttc agtacacttt gaacaaacca gaaagcttct   540
ggaattctaa gacaaccatg ggtgtgcttg cgccagttaa tgaagagttt ttgaattcaa   600
aaggagatga ttttgccaaa gctacggatc caagtagtct cttgtataac ggtccttatt   660
tgttgaaatc cattgtgacc aaatcctctg ttgaatttgc gaaaaatccg aactactggg   720
ataaggacaa tgtgcatgtt gacaaagtta aattgtcatt ctgggatggt caagatacca   780
gcaaacctgc agaaaacttt aaagatggta gccttacagc agctcgtctc tatccaacaa   840
gtgcaagttt cgcagaactt gagaagagta tgaaggacaa tattgtctat actcaacaag   900
actctattac gtatctagtt ggtacaaata ttgaccgtca gtcctataaa tacacatcta   960
agaccagcga cgaacaaaag gcatcgacta aaaaggctct cttaaacaag gatttccgtc   1020
aggctattgc ctttggattt gaccgtacag cctatgcctc tcagttgaat ggacaaactg   1080
gagcaagtaa aatcttgcgt aatctctttg tgccaccaac atttgttcaa gcagatggta   1140
aaaactttgg cgatatggtc aaagagaaat tggtcactta tggggatgaa tggaaggatg   1200
ttaatcttgc agattctcag gatggtcttt acaatccaga aaaagccaag gctgaatttg   1260
ctaaagctaa atcagcctta caagcagaag gagtccaatt cccaattcat ttggatatgc   1320
cagttgacca aacagcaact acaaaagttc agcgcgtcca atctatgaaa caatccttgg   1380
aagcaacttt aggagctgat aatgtcatta ttgatattca acaactacaa aaagacgaag   1440
taaacaatat tacatatttt gctgaaaatg ctgctggcga agactgggat ttatcagata   1500
atgtcggttg gggtccagac tttgccgatc catcaaccta ccttgatatt atcaaacctt   1560
ctgtaggaga aagtactaaa acatatttag ggtttgactc aggggaagat aatgtagctg   1620
ctaaaaaagt aggtctatat gactacgaaa aattggttac tgaggctggt gatgagacta   1680
cagatgttgc taaacgctat gataaatacg ctgcagccca agcttggttg acagatagtg   1740
ctttgattat tccaactaca tctcgtacag ggcgtccaat cttgtctaag atggtaccat   1800
ttacaatacc atttgcattg tcaggaaata aaggtacaag tgaaccagtc ttgtataaat   1860
acttggaact tcaagacaag gcagtcactg tagatgaata ccaaaaagct caggaaaaat   1920
ggatgaaaga aaaagaagag tctaataaaa aggctcaaga agatctcgca aaacatgtga   1980
aa                                                                  1982

<210>   566
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligopeptide ABC transporter, oligopeptide-binding protein AliA FRAMESH

<400>   566
Met Met Lys Ser Ser Lys Leu Phe Ala Leu Ala Gly Val Thr Leu Leu 
1               5                   10                  15      

Ala Ala Thr Thr Leu Ala Ala Cys Ser Gly Ser Gly Ser Ser Thr Lys 
            20                  25                  30          

Gly Glu Lys Thr Phe Ser Tyr Ile Tyr Glu Thr Asp Pro Asp Asn Leu 
        35                  40                  45              

Asn Tyr Leu Thr Thr Ala Lys Ala Ala Thr Gln Ile Leu Pro Val Thr 
    50                  55                  60                  

Trp Leu Met Val Cys 
65                  

<210>   567
<211>   1791
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   567
gtggttgatg gtttgctaga aaatgatcgc tacgggaact ttgtgccgtc tatggctgag   60
gattggtctg tatccaagga tggattgact tacacttata ctatccgtaa ggatgcaaaa   120
tggtatactt ctgaaggtga agaatacgcg gcagtcaaag ctcaagactt tgtaacagga   180
ttaaaatatg ctgctgataa aaaatcagat gctctttacc ttgttcaaga atcaatcaaa   240
gggttggatg cctatgtaaa aggggaaatc aaagatttct cacaagtagg aattaaggct   300
ctggatgaac agacagttca gtacactttg aacaaaccag aaagcttctg gaattctaag   360
acaaccatgg gtgtgcttgc gccagttaat gaagagtttt tgaattcaaa aggagatgat   420
tttgccaaag ctacggatcc aagtagtctc ttgtataacg gtccttattt gttgaaatcc   480
attgtgacca aatcctctgt tgaatttgcg aaaaatccga actactggga taaggacaat   540
gtgcatgttg acaaagttaa attgtcattc tgggatggtc aagataccag caaacctgca   600
gaaaacttta aagatggtag ccttacagca gctcgtctct atccaacaag tgcaagtttc   660
gcagaacttg agaagagtat gaaggacaat attgtctata ctcaacaaga ctctattacg   720
tatctagttg gtacaaatat tgaccgtcag tcctataaat acacatctaa gaccagcgac   780
gaacaaaagg catcgactaa aaaggctctc ttaaacaagg atttccgtca ggctattgcc   840
tttggatttg accgtacagc ctatgcctct cagttgaatg gacaaactgg agcaagtaaa   900
atcttgcgta atctctttgt gccaccaaca tttgttcaag cagatggtaa aaactttggc   960
gatatggtca aagagaaatt ggtcacttat ggggatgaat ggaaggatgt taatcttgca   1020
gattctcagg atggtcttta caatccagaa aaagccaagg ctgaatttgc taaagctaaa   1080
tcagccttac aagcagaagg agtccaattc ccaattcatt tggatatgcc agttgaccaa   1140
acagcaacta caaaagttca gcgcgtccaa tctatgaaac aatccttgga agcaacttta   1200
ggagctgata atgtcattat tgatattcaa caactacaaa aagacgaagt aaacaatatt   1260
acatattttg ctgaaaatgc tgctggcgaa gactgggatt tatcagataa tgtcggttgg   1320
ggtccagact ttgccgatcc atcaacctac cttgatatta tcaaaccttc tgtaggagaa   1380
agtactaaaa catatttagg gtttgactca ggggaagata atgtagctgc taaaaaagta   1440
ggtctatatg actacgaaaa attggttact gaggctggtg atgagactac agatgttgct   1500
aaacgctatg ataaatacgc tgcagcccaa gcttggttga cagatagtgc tttgattatt   1560
ccaactacat ctcgtacagg gcgtccaatc ttgtctaaga tggtaccatt tacaatacca   1620
tttgcattgt caggaaataa aggtacaagt gaaccagtct tgtataaata cttggaactt   1680
caagacaagg cagtcactgt agatgaatac caaaaagctc aggaaaaatg gatgaaagaa   1740
aaagaagagt ctaataaaaa ggctcaagaa gatctcgcaa aacatgtgaa a            1791

<210>   568
<211>   597
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligopeptide-binding protein alia precursor (exported protein 1)

<400>   568
Met Val Asp Gly Leu Leu Glu Asn Asp Arg Tyr Gly Asn Phe Val Pro 
1               5                   10                  15      

Ser Met Ala Glu Asp Trp Ser Val Ser Lys Asp Gly Leu Thr Tyr Thr 
            20                  25                  30          

Tyr Thr Ile Arg Lys Asp Ala Lys Trp Tyr Thr Ser Glu Gly Glu Glu 
        35                  40                  45              

Tyr Ala Ala Val Lys Ala Gln Asp Phe Val Thr Gly Leu Lys Tyr Ala 
    50                  55                  60                  

Ala Asp Lys Lys Ser Asp Ala Leu Tyr Leu Val Gln Glu Ser Ile Lys 
65                  70                  75                  80  

Gly Leu Asp Ala Tyr Val Lys Gly Glu Ile Lys Asp Phe Ser Gln Val 
                85                  90                  95      

Gly Ile Lys Ala Leu Asp Glu Gln Thr Val Gln Tyr Thr Leu Asn Lys 
            100                 105                 110         

Pro Glu Ser Phe Trp Asn Ser Lys Thr Thr Met Gly Val Leu Ala Pro 
        115                 120                 125             

Val Asn Glu Glu Phe Leu Asn Ser Lys Gly Asp Asp Phe Ala Lys Ala 
    130                 135                 140                 

Thr Asp Pro Ser Ser Leu Leu Tyr Asn Gly Pro Tyr Leu Leu Lys Ser 
145                 150                 155                 160 

Ile Val Thr Lys Ser Ser Val Glu Phe Ala Lys Asn Pro Asn Tyr Trp 
                165                 170                 175     

Asp Lys Asp Asn Val His Val Asp Lys Val Lys Leu Ser Phe Trp Asp 
            180                 185                 190         

Gly Gln Asp Thr Ser Lys Pro Ala Glu Asn Phe Lys Asp Gly Ser Leu 
        195                 200                 205             

Thr Ala Ala Arg Leu Tyr Pro Thr Ser Ala Ser Phe Ala Glu Leu Glu 
    210                 215                 220                 


Lys Ser Met Lys Asp Asn Ile Val Tyr Thr Gln Gln Asp Ser Ile Thr 
225                 230                 235                 240 

Tyr Leu Val Gly Thr Asn Ile Asp Arg Gln Ser Tyr Lys Tyr Thr Ser 
                245                 250                 255     

Lys Thr Ser Asp Glu Gln Lys Ala Ser Thr Lys Lys Ala Leu Leu Asn 
            260                 265                 270         

Lys Asp Phe Arg Gln Ala Ile Ala Phe Gly Phe Asp Arg Thr Ala Tyr 
        275                 280                 285             

Ala Ser Gln Leu Asn Gly Gln Thr Gly Ala Ser Lys Ile Leu Arg Asn 
    290                 295                 300                 

Leu Phe Val Pro Pro Thr Phe Val Gln Ala Asp Gly Lys Asn Phe Gly 
305                 310                 315                 320 

Asp Met Val Lys Glu Lys Leu Val Thr Tyr Gly Asp Glu Trp Lys Asp 
                325                 330                 335     

Val Asn Leu Ala Asp Ser Gln Asp Gly Leu Tyr Asn Pro Glu Lys Ala 
            340                 345                 350         

Lys Ala Glu Phe Ala Lys Ala Lys Ser Ala Leu Gln Ala Glu Gly Val 
        355                 360                 365             

Gln Phe Pro Ile His Leu Asp Met Pro Val Asp Gln Thr Ala Thr Thr 
    370                 375                 380                 

Lys Val Gln Arg Val Gln Ser Met Lys Gln Ser Leu Glu Ala Thr Leu 
385                 390                 395                 400 

Gly Ala Asp Asn Val Ile Ile Asp Ile Gln Gln Leu Gln Lys Asp Glu 
                405                 410                 415     

Val Asn Asn Ile Thr Tyr Phe Ala Glu Asn Ala Ala Gly Glu Asp Trp 
            420                 425                 430         

Asp Leu Ser Asp Asn Val Gly Trp Gly Pro Asp Phe Ala Asp Pro Ser 
        435                 440                 445             

Thr Tyr Leu Asp Ile Ile Lys Pro Ser Val Gly Glu Ser Thr Lys Thr 
    450                 455                 460                 

Tyr Leu Gly Phe Asp Ser Gly Glu Asp Asn Val Ala Ala Lys Lys Val 
465                 470                 475                 480 

Gly Leu Tyr Asp Tyr Glu Lys Leu Val Thr Glu Ala Gly Asp Glu Thr 
                485                 490                 495     

Thr Asp Val Ala Lys Arg Tyr Asp Lys Tyr Ala Ala Ala Gln Ala Trp 
            500                 505                 510         

Leu Thr Asp Ser Ala Leu Ile Ile Pro Thr Thr Ser Arg Thr Gly Arg 
        515                 520                 525             

Pro Ile Leu Ser Lys Met Val Pro Phe Thr Ile Pro Phe Ala Leu Ser 
    530                 535                 540                 

Gly Asn Lys Gly Thr Ser Glu Pro Val Leu Tyr Lys Tyr Leu Glu Leu 
545                 550                 555                 560 

Gln Asp Lys Ala Val Thr Val Asp Glu Tyr Gln Lys Ala Gln Glu Lys 
                565                 570                 575     

Trp Met Lys Glu Lys Glu Glu Ser Asn Lys Lys Ala Gln Glu Asp Leu 
            580                 585                 590         

Ala Lys His Val Lys 
        595         

<210>   569
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   569
ttgtttccta ttgctttctc agctattatt tgttatatta aaagtataat tattttttat   60
ttatcagagt taagcattgc actttcagag gaaggagtat tttttaaaaa gaaaatg      117

<210>   570
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   570
Met Phe Pro Ile Ala Phe Ser Ala Ile Ile Cys Tyr Ile Lys Ser Ile 
1               5                   10                  15      

Ile Ile Phe Tyr Leu Ser Glu Leu Ser Ile Ala Leu Ser Glu Glu Gly 
            20                  25                  30          

Val Phe Phe Lys Lys Lys Met 
        35                  

<210>   571
<211>   5301
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   571
atgaataaag gattatttga aaaacgttgt aaatatagta ttcggaaatt ttcattaggt   60
gttgcttctg ttatgattgg agctgcattc tttgggacaa gtccggttct tgcagatagc   120
gtgcagtctg gttccacggc gaacttacca gctgatttag ctactgctct tgcaacagca   180
aaagagaatg atgggcgtga ttttgaagcg cctaaggtgg gagaagacca aggttctcca   240
gaagttacag atggacctaa gacagaagaa gaactattag cacttgaaaa agaaaaaccg   300
gctgaagaaa aaccaaaaga ggataaacct gcagctgcta aacctgaaac acctaagacg   360
gtaacccctg aatggcaaac ggtagcgaat aaagagcaac agggaacagt cactatccga   420
gaagaaaaag gtgtccgcta caaccaacta tcctcaactg ctcaaaatga taacgcaggc   480
aaaccagccc tgtttgaaaa gaagggcttg accgttgatg ccaatggaaa tgcaactgtt   540
gatttaacct tcaaagatga ttctgaaaag ggcaaatcac gctttggtgt ctttttgaaa   600
tttaaagata ccaagaataa tgtttttgtc ggttatgaca aggatggctg gttctgggag   660
tataaatctc caacaactag cacttggtat agaggtagtc gtgttgctgc tcctgaaaca   720
ggatcaacaa accgtctctc tatcactctc aagtcagacg gtcagctaaa tgccagcaat   780
aatgatgtca atctctttga cacagtgact ctaccagctg cggtcaatga ccatcttaaa   840
aatgagaaga agattcttct caaggcgggc tcttatgacg atgagcgaac agttgttagc   900
gttaaaacgg ataaccaaga gggggtaaaa acagaggata cccctgctga aaaagaaaca   960
ggtcctgaag ttgatgatag caaggtgact tatgacacga ttcagtctaa ggtcctcaaa   1020
gcagtgattg accaagcctt ccctcgtgtc aaggaataca gcttgaacgg gcatactttg   1080
ccaggacagg tgcaacagtt caaccaagtc tttatcaata accaccgaat cacccctgaa   1140
gtcacttata agaaaatcaa tgagacaaca gcagagtact tgatgaagct tcgcgatgat   1200
gctcacttaa tcaatgcgga aatgacagta cgcttgcaag ttgtagacaa tcaattgcac   1260
tttgatgtga ctaagattgt caaccacaat caagtcactc caggtcaaaa gattgatgac   1320
gaaagcaaac tactttcttc tattagtttc ctcggcaatg ctttagtctc tgtttctagt   1380
aatcaaactg gtgctaagtt tgatggggca accatgtcaa acaatacgca tgtcagcgga   1440
gatgatcata tcgatgtaac caatccaatg aaggatttgg ctaagggtta catgtatgga   1500
tttgtttcta cagataagct tgctgctggt gtttggagta actctcaaaa cagctatggt   1560
ggtggttcga atgactggac tcgtttgaca gcttataaag aaacagtcgg aaatgccaac   1620
tatgtaggaa tccacagctc tgaatggcaa tgggaaaaag cttataaggg cattgttttc   1680
ccagaataca cgaaggaact tccaagtgct aaggttgtta tcactgaaga tgccaatgca   1740
gacaagaacg ttgattggca agatggtgcc attgcttatc gtagcattat gaacaatcct   1800
caaggttggg aaaaagttaa ggatatcaca gcttaccgta tcgcgatgaa ctttggttct   1860
caagcacaaa acccattcct tatgaccttg gatggtatca agaaaatcaa tctccataca   1920
gatggtcttg ggcaaggtgt tctccttaaa ggatatggta gcgaaggcca tgactctggt   1980
cacttgaact atgctgatat tggtaagcgt atcggtggtg tcgaagactt caagacccta   2040
attgagaagg ctaagaaata tggagctcat ctaggtatcc acgttaacgc ttcagaaact   2100
tatcctgagt ctaaatactt caatgaaaaa attctccgta agaatccaga tggaagctat   2160
agctatggtt ggaactggct agatcaaggt atcaacattg atgctgccta tgacctagct   2220
catggtcgtt tggcacgttg ggaagatttg aagaaaaaac ttggtgacgg tctcgacttt   2280
atctatgtgg acgtttgggg taatggtcaa tcaggtgata acggtgcctg ggctacccac   2340
gttcttgcta aagaaattaa caaacaaggc tggcgctttg cgatcgagtg gggccatggt   2400
ggtgagtacg actctacctt ccatcactgg gcagctgact tgacctacgg tggctacacc   2460
aataaaggta tcaacagtgc catcacccgc tttatccgta accaccaaaa agatgcttgg   2520
gtaggggact acagaagtta tggtggtgca gccaactatc cactgctagg tggctacagc   2580
atgaaagact ttgaaggctg gcagggaaga agtgactaca atggctatgt aaccaactta   2640
tttgcccatg acgtcatgac taagtacttc caacacttca ctgtaagtaa atgggaaaat   2700
ggtacaccgg tgactatgac cgataacggt agcacctata aatggactcc agaaatgcga   2760
gtggaattgg tagatgctga caataataaa gtagttgtaa ctcgtaagtc aaatgatgtc   2820
aatagtccac aatatcgcga acgtacagta acgctcaacg gacgtgtcat ccaagatggt   2880
tcagcttact tgactccttg gaactgggat gcaaatggta agaaactttc tactgataag   2940
gaaaagatgt actacttcaa tacgcaggcc ggtgcaacaa cttggaccct tccaagcgat   3000
tgggcaaaga gcaaggttta cctttacaag ctaactgacc aaggtaagac agaagagcaa   3060
gaactaactg taaaagatgg taaaattacc ctagatcttc tagcaaatca accatacgtt   3120
ctctatcgtt cgaaacaaac taatcctgaa atgtcatgga gtgaaggcat gcacatctat   3180
gaccaaggat ttaatagcgg taccttgaaa cattggacca tttcaggcga tgcttctaag   3240
gcagaaattg tcaagtctca aggggcaaac gatatgcttc gtattcaagg aaacaaagaa   3300
aaagttagtc tcactcagaa attaactggc ttgaaaccaa ataccaagta tgccgtttat   3360
gttggtgtag ataaccgtag taatgccaag gcaagtatca ctgtgaatac tggtgaaaaa   3420
gaagtgacta cttataccaa taagtctctc gcgctcaact atgttaaggc ctacgcccac   3480
aatacacgtc gtgacaatgc tacagttgac gatacaagtt acttccaaaa catgtacgcc   3540
ttctttacaa ctggagcgga cgtctcaaat gttactctga cattgagtcg tgaagctggt   3600
gatcaagcaa cttactttga tgaaattcgt acctttgaaa acaattcaag catgtacgga   3660
gacaagcatg atacaggtaa aggcaccttc aagcaagact ttgaaaatgt tgctcagggt   3720
atcttcccat ttgtagtggg tggtgtcgaa ggtgttgaag ataaccgcac tcacttgtct   3780
gaaaaacaca atccatatac acaacgtggt tggaatggta agaaagtcga tgatgttatc   3840
gaaggaaatt ggtcactcaa gacaaatgga ctagtgagcc gtcgtaactt ggtttaccaa   3900
accatcccac aaaacttccg ttttgaagca ggtaagacct accgtgtaac ctttgaatac   3960
gaagcaggat cagacaatac ctatgctttt gtagtcggta agggagaatt ccagtcaggt   4020
cgtcgtggta ctcaagcaag caacttggaa atgcatgaat tgccaaatac ttggacagat   4080
tctaagaaag ccaagaaggc aaccttcctt gtgacaggtg cagaaacagg cgatacttgg   4140
gtaggtatct actcaactgg aaatgcaagt aatactcgtg gtgattctgg tggaaatgcc   4200
aacttccgtg gttataacga cttcatgatg gataatcttc aaatcgaaga aattacccta   4260
acaggtaaga tgttgacaga aaatgctctg aagaactact tgccaacggt tgccatgact   4320
aactacacca aagagtctat ggatgctttg aaagaggcgg tctttaacct cagtcaggcc   4380
gatgatgata tcagtgtgga agaagcgcgt gcagagattg ccaagattga agctttgaag   4440
aatgctttgg ttcagaagaa gacggctttg gtagcagatg actttgcaag tcttacagct   4500
cctgctcagg ctcaagaagg tcttgcaaat gcctttgatg gcaatgtgtc tagtctatgg   4560
catacatctt ggaatggtgg agatgtaggc aagcctgcaa ctatggtctt gaaagaacca   4620
actgaaatca caggacttcg ctatgttccg cgtggatcag gttcaaatgg taacttgcga   4680
gatgtgaaac ttgttgtgac agatgagtct ggcaaggagc atacctttac tgcaactgat   4740
tggccaaata acaacaaacc aaaagatatt gactttggta agacaatcaa ggctaagaaa   4800
attgtcctta ctggtaccaa gacatacgga gatggtggag ataaatacca atctgcagcg   4860
gaacttatct ttactcgtcc acaggtagca gaaacacctc ttgacttgtc aggctatgaa   4920
gcagctttgg ttaaggctca gaaattaaca gacaaagaca atcaagagga agtagctagc   4980
gttcaggcaa gcatgaaata tgcgacggat aaccatctct tgacggaaag aatggtggaa   5040
tactttgcag attatctcaa ccaattaaaa gattctgcta cgaaaccaga tgctccaact   5100
gtagagaaac ctgagtttaa acttagatct ttagcttccg agcaaggtaa gacgccagat   5160
tataagcaag aaatagctag accagaaaca cctgaacaaa tcttgccagc aacaggtgag   5220
agtcaatctg acacagccct catcctagca agtgttagtc tagccctatc tgctctcttt   5280
gtagtaaaaa cgaagaaaga c                                             5301

<210>   572
<211>   1767
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell wall surface anchor family protein FRAMESHIFT
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15902372 (0.E+01)

<400>   572
Met Asn Lys Gly Leu Phe Glu Lys Arg Cys Lys Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ser Leu Gly Val Ala Ser Val Met Ile Gly Ala Ala Phe Phe Gly 
            20                  25                  30          

Thr Ser Pro Val Leu Ala Asp Ser Val Gln Ser Gly Ser Thr Ala Asn 
        35                  40                  45              

Leu Pro Ala Asp Leu Ala Thr Ala Leu Ala Thr Ala Lys Glu Asn Asp 
    50                  55                  60                  

Gly Arg Asp Phe Glu Ala Pro Lys Val Gly Glu Asp Gln Gly Ser Pro 
65                  70                  75                  80  

Glu Val Thr Asp Gly Pro Lys Thr Glu Glu Glu Leu Leu Ala Leu Glu 
                85                  90                  95      

Lys Glu Lys Pro Ala Glu Glu Lys Pro Lys Glu Asp Lys Pro Ala Ala 
            100                 105                 110         

Ala Lys Pro Glu Thr Pro Lys Thr Val Thr Pro Glu Trp Gln Thr Val 
        115                 120                 125             

Ala Asn Lys Glu Gln Gln Gly Thr Val Thr Ile Arg Glu Glu Lys Gly 
    130                 135                 140                 

Val Arg Tyr Asn Gln Leu Ser Ser Thr Ala Gln Asn Asp Asn Ala Gly 
145                 150                 155                 160 

Lys Pro Ala Leu Phe Glu Lys Lys Gly Leu Thr Val Asp Ala Asn Gly 
                165                 170                 175     

Asn Ala Thr Val Asp Leu Thr Phe Lys Asp Asp Ser Glu Lys Gly Lys 
            180                 185                 190         

Ser Arg Phe Gly Val Phe Leu Lys Phe Lys Asp Thr Lys Asn Asn Val 
        195                 200                 205             

Phe Val Gly Tyr Asp Lys Asp Gly Trp Phe Trp Glu Tyr Lys Ser Pro 
    210                 215                 220                 

Thr Thr Ser Thr Trp Tyr Arg Gly Ser Arg Val Ala Ala Pro Glu Thr 
225                 230                 235                 240 

Gly Ser Thr Asn Arg Leu Ser Ile Thr Leu Lys Ser Asp Gly Gln Leu 
                245                 250                 255     

Asn Ala Ser Asn Asn Asp Val Asn Leu Phe Asp Thr Val Thr Leu Pro 
            260                 265                 270         

Ala Ala Val Asn Asp His Leu Lys Asn Glu Lys Lys Ile Leu Leu Lys 
        275                 280                 285             

Ala Gly Ser Tyr Asp Asp Glu Arg Thr Val Val Ser Val Lys Thr Asp 
    290                 295                 300                 

Asn Gln Glu Gly Val Lys Thr Glu Asp Thr Pro Ala Glu Lys Glu Thr 
305                 310                 315                 320 

Gly Pro Glu Val Asp Asp Ser Lys Val Thr Tyr Asp Thr Ile Gln Ser 
                325                 330                 335     

Lys Val Leu Lys Ala Val Ile Asp Gln Ala Phe Pro Arg Val Lys Glu 
            340                 345                 350         

Tyr Ser Leu Asn Gly His Thr Leu Pro Gly Gln Val Gln Gln Phe Asn 
        355                 360                 365             

Gln Val Phe Ile Asn Asn His Arg Ile Thr Pro Glu Val Thr Tyr Lys 
    370                 375                 380                 

Lys Ile Asn Glu Thr Thr Ala Glu Tyr Leu Met Lys Leu Arg Asp Asp 
385                 390                 395                 400 

Ala His Leu Ile Asn Ala Glu Met Thr Val Arg Leu Gln Val Val Asp 
                405                 410                 415     

Asn Gln Leu His Phe Asp Val Thr Lys Ile Val Asn His Asn Gln Val 
            420                 425                 430         

Thr Pro Gly Gln Lys Ile Asp Asp Glu Ser Lys Leu Leu Ser Ser Ile 
        435                 440                 445             

Ser Phe Leu Gly Asn Ala Leu Val Ser Val Ser Ser Asn Gln Thr Gly 
    450                 455                 460                 

Ala Lys Phe Asp Gly Ala Thr Met Ser Asn Asn Thr His Val Ser Gly 
465                 470                 475                 480 

Asp Asp His Ile Asp Val Thr Asn Pro Met Lys Asp Leu Ala Lys Gly 
                485                 490                 495     

Tyr Met Tyr Gly Phe Val Ser Thr Asp Lys Leu Ala Ala Gly Val Trp 
            500                 505                 510         

Ser Asn Ser Gln Asn Ser Tyr Gly Gly Gly Ser Asn Asp Trp Thr Arg 
        515                 520                 525             

Leu Thr Ala Tyr Lys Glu Thr Val Gly Asn Ala Asn Tyr Val Gly Ile 
    530                 535                 540                 

His Ser Ser Glu Trp Gln Trp Glu Lys Ala Tyr Lys Gly Ile Val Phe 
545                 550                 555                 560 

Pro Glu Tyr Thr Lys Glu Leu Pro Ser Ala Lys Val Val Ile Thr Glu 
                565                 570                 575     

Asp Ala Asn Ala Asp Lys Asn Val Asp Trp Gln Asp Gly Ala Ile Ala 
            580                 585                 590         

Tyr Arg Ser Ile Met Asn Asn Pro Gln Gly Trp Glu Lys Val Lys Asp 
        595                 600                 605             

Ile Thr Ala Tyr Arg Ile Ala Met Asn Phe Gly Ser Gln Ala Gln Asn 
    610                 615                 620                 

Pro Phe Leu Met Thr Leu Asp Gly Ile Lys Lys Ile Asn Leu His Thr 
625                 630                 635                 640 

Asp Gly Leu Gly Gln Gly Val Leu Leu Lys Gly Tyr Gly Ser Glu Gly 
                645                 650                 655     

His Asp Ser Gly His Leu Asn Tyr Ala Asp Ile Gly Lys Arg Ile Gly 
            660                 665                 670         

Gly Val Glu Asp Phe Lys Thr Leu Ile Glu Lys Ala Lys Lys Tyr Gly 
        675                 680                 685             

Ala His Leu Gly Ile His Val Asn Ala Ser Glu Thr Tyr Pro Glu Ser 
    690                 695                 700                 

Lys Tyr Phe Asn Glu Lys Ile Leu Arg Lys Asn Pro Asp Gly Ser Tyr 
705                 710                 715                 720 

Ser Tyr Gly Trp Asn Trp Leu Asp Gln Gly Ile Asn Ile Asp Ala Ala 
                725                 730                 735     

Tyr Asp Leu Ala His Gly Arg Leu Ala Arg Trp Glu Asp Leu Lys Lys 
            740                 745                 750         

Lys Leu Gly Asp Gly Leu Asp Phe Ile Tyr Val Asp Val Trp Gly Asn 
        755                 760                 765             

Gly Gln Ser Gly Asp Asn Gly Ala Trp Ala Thr His Val Leu Ala Lys 
    770                 775                 780                 

Glu Ile Asn Lys Gln Gly Trp Arg Phe Ala Ile Glu Trp Gly His Gly 
785                 790                 795                 800 

Gly Glu Tyr Asp Ser Thr Phe His His Trp Ala Ala Asp Leu Thr Tyr 
                805                 810                 815     

Gly Gly Tyr Thr Asn Lys Gly Ile Asn Ser Ala Ile Thr Arg Phe Ile 
            820                 825                 830         

Arg Asn His Gln Lys Asp Ala Trp Val Gly Asp Tyr Arg Ser Tyr Gly 
        835                 840                 845             

Gly Ala Ala Asn Tyr Pro Leu Leu Gly Gly Tyr Ser Met Lys Asp Phe 
    850                 855                 860                 

Glu Gly Trp Gln Gly Arg Ser Asp Tyr Asn Gly Tyr Val Thr Asn Leu 
865                 870                 875                 880 

Phe Ala His Asp Val Met Thr Lys Tyr Phe Gln His Phe Thr Val Ser 
                885                 890                 895     

Lys Trp Glu Asn Gly Thr Pro Val Thr Met Thr Asp Asn Gly Ser Thr 
            900                 905                 910         

Tyr Lys Trp Thr Pro Glu Met Arg Val Glu Leu Val Asp Ala Asp Asn 
        915                 920                 925             

Asn Lys Val Val Val Thr Arg Lys Ser Asn Asp Val Asn Ser Pro Gln 
    930                 935                 940                 

Tyr Arg Glu Arg Thr Val Thr Leu Asn Gly Arg Val Ile Gln Asp Gly 
945                 950                 955                 960 

Ser Ala Tyr Leu Thr Pro Trp Asn Trp Asp Ala Asn Gly Lys Lys Leu 
                965                 970                 975     

Ser Thr Asp Lys Glu Lys Met Tyr Tyr Phe Asn Thr Gln Ala Gly Ala 
            980                 985                 990         

Thr Thr Trp Thr Leu Pro Ser Asp Trp Ala Lys Ser Lys Val Tyr Leu 
        995                 1000                1005            

Tyr Lys Leu Thr Asp Gln Gly Lys Thr Glu Glu Gln Glu Leu Thr Val 
    1010                1015                1020                

Lys Asp Gly Lys Ile Thr Leu Asp Leu Leu Ala Asn Gln Pro Tyr Val 
1025                1030                1035                1040

Leu Tyr Arg Ser Lys Gln Thr Asn Pro Glu Met Ser Trp Ser Glu Gly 
                1045                1050                1055    

Met His Ile Tyr Asp Gln Gly Phe Asn Ser Gly Thr Leu Lys His Trp 
            1060                1065                1070        

Thr Ile Ser Gly Asp Ala Ser Lys Ala Glu Ile Val Lys Ser Gln Gly 
        1075                1080                1085            

Ala Asn Asp Met Leu Arg Ile Gln Gly Asn Lys Glu Lys Val Ser Leu 
    1090                1095                1100                

Thr Gln Lys Leu Thr Gly Leu Lys Pro Asn Thr Lys Tyr Ala Val Tyr 
1105                1110                1115                1120

Val Gly Val Asp Asn Arg Ser Asn Ala Lys Ala Ser Ile Thr Val Asn 
                1125                1130                1135    

Thr Gly Glu Lys Glu Val Thr Thr Tyr Thr Asn Lys Ser Leu Ala Leu 
            1140                1145                1150        

Asn Tyr Val Lys Ala Tyr Ala His Asn Thr Arg Arg Asp Asn Ala Thr 
        1155                1160                1165            

Val Asp Asp Thr Ser Tyr Phe Gln Asn Met Tyr Ala Phe Phe Thr Thr 
    1170                1175                1180                

Gly Ala Asp Val Ser Asn Val Thr Leu Thr Leu Ser Arg Glu Ala Gly 
1185                1190                1195                1200

Asp Gln Ala Thr Tyr Phe Asp Glu Ile Arg Thr Phe Glu Asn Asn Ser 
                1205                1210                1215    

Ser Met Tyr Gly Asp Lys His Asp Thr Gly Lys Gly Thr Phe Lys Gln 
            1220                1225                1230        

Asp Phe Glu Asn Val Ala Gln Gly Ile Phe Pro Phe Val Val Gly Gly 
        1235                1240                1245            

Val Glu Gly Val Glu Asp Asn Arg Thr His Leu Ser Glu Lys His Asn 
    1250                1255                1260                

Pro Tyr Thr Gln Arg Gly Trp Asn Gly Lys Lys Val Asp Asp Val Ile 
1265                1270                1275                1280

Glu Gly Asn Trp Ser Leu Lys Thr Asn Gly Leu Val Ser Arg Arg Asn 
                1285                1290                1295    

Leu Val Tyr Gln Thr Ile Pro Gln Asn Phe Arg Phe Glu Ala Gly Lys 
            1300                1305                1310        

Thr Tyr Arg Val Thr Phe Glu Tyr Glu Ala Gly Ser Asp Asn Thr Tyr 
        1315                1320                1325            

Ala Phe Val Val Gly Lys Gly Glu Phe Gln Ser Gly Arg Arg Gly Thr 
    1330                1335                1340                

Gln Ala Ser Asn Leu Glu Met His Glu Leu Pro Asn Thr Trp Thr Asp 
1345                1350                1355                1360

Ser Lys Lys Ala Lys Lys Ala Thr Phe Leu Val Thr Gly Ala Glu Thr 
                1365                1370                1375    

Gly Asp Thr Trp Val Gly Ile Tyr Ser Thr Gly Asn Ala Ser Asn Thr 
            1380                1385                1390        

Arg Gly Asp Ser Gly Gly Asn Ala Asn Phe Arg Gly Tyr Asn Asp Phe 
        1395                1400                1405            

Met Met Asp Asn Leu Gln Ile Glu Glu Ile Thr Leu Thr Gly Lys Met 
    1410                1415                1420                

Leu Thr Glu Asn Ala Leu Lys Asn Tyr Leu Pro Thr Val Ala Met Thr 
1425                1430                1435                1440

Asn Tyr Thr Lys Glu Ser Met Asp Ala Leu Lys Glu Ala Val Phe Asn 
                1445                1450                1455    

Leu Ser Gln Ala Asp Asp Asp Ile Ser Val Glu Glu Ala Arg Ala Glu 
            1460                1465                1470        

Ile Ala Lys Ile Glu Ala Leu Lys Asn Ala Leu Val Gln Lys Lys Thr 
        1475                1480                1485            

Ala Leu Val Ala Asp Asp Phe Ala Ser Leu Thr Ala Pro Ala Gln Ala 
    1490                1495                1500                

Gln Glu Gly Leu Ala Asn Ala Phe Asp Gly Asn Val Ser Ser Leu Trp 
1505                1510                1515                1520

His Thr Ser Trp Asn Gly Gly Asp Val Gly Lys Pro Ala Thr Met Val 
                1525                1530                1535    

Leu Lys Glu Pro Thr Glu Ile Thr Gly Leu Arg Tyr Val Pro Arg Gly 
            1540                1545                1550        

Ser Gly Ser Asn Gly Asn Leu Arg Asp Val Lys Leu Val Val Thr Asp 
        1555                1560                1565            

Glu Ser Gly Lys Glu His Thr Phe Thr Ala Thr Asp Trp Pro Asn Asn 
    1570                1575                1580                

Asn Lys Pro Lys Asp Ile Asp Phe Gly Lys Thr Ile Lys Ala Lys Lys 
1585                1590                1595                1600

Ile Val Leu Thr Gly Thr Lys Thr Tyr Gly Asp Gly Gly Asp Lys Tyr 
                1605                1610                1615    

Gln Ser Ala Ala Glu Leu Ile Phe Thr Arg Pro Gln Val Ala Glu Thr 
            1620                1625                1630        

Pro Leu Asp Leu Ser Gly Tyr Glu Ala Ala Leu Val Lys Ala Gln Lys 
        1635                1640                1645            

Leu Thr Asp Lys Asp Asn Gln Glu Glu Val Ala Ser Val Gln Ala Ser 
    1650                1655                1660                

Met Lys Tyr Ala Thr Asp Asn His Leu Leu Thr Glu Arg Met Val Glu 
1665                1670                1675                1680

Tyr Phe Ala Asp Tyr Leu Asn Gln Leu Lys Asp Ser Ala Thr Lys Pro 
                1685                1690                1695    

Asp Ala Pro Thr Val Glu Lys Pro Glu Phe Lys Leu Arg Ser Leu Ala 
            1700                1705                1710        

Ser Glu Gln Gly Lys Thr Pro Asp Tyr Lys Gln Glu Ile Ala Arg Pro 
        1715                1720                1725            

Glu Thr Pro Glu Gln Ile Leu Pro Ala Thr Gly Glu Ser Gln Ser Asp 
    1730                1735                1740                

Thr Ala Leu Ile Leu Ala Ser Val Ser Leu Ala Leu Ser Ala Leu Phe 
1745                1750                1755                1760

Val Val Lys Thr Lys Lys Asp 
                1765        

<210>   573
<211>   2157
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   573
atgaacaaac caacgattct gcgcctaatc aagtatctga gcattagctt cttaagcttg   60

gttatcgcag ccattgtctt aggcggagga gtttttttct actacgttag caaggctcct   120
agcctatccg agagtaaact agttgcaaca acttctagta aaatctacga caataaaaat   180
caactcattg ctgacttggg ttctgaacgc cgcgtcaatg cccaagctaa tgatattccc   240
acagatttgg ttaaggcaat cgtttctatc gaagaccatc gcttcttcga ccacaggggg   300
attgatacca tccgtatcct gggagctttc ttgcgcaatc tgcaaagcaa ttccctccaa   360
ggtggatcaa ctctcaccca acagttgatt aagttgactt acttttcaac ttcgacttcc   420
gaccagacta tttctcgtaa ggctcaggaa gcttggttag cgattcagtt agaacaaaaa   480
gcaaccaagc aagaaatctt gacctactat ataaataagg tctacatgtc taatgggaac   540
tatggaatgc agacagcagc tcaaaactac tatggtaaag acctcaataa tttaagttta   600
cctcagttag ccttgctggc tggaatgcct caggcaccaa accaatatga cccctattca   660
catccagaag cagcccaaga ccgccgaaac ttggtcttat ctgaaatgaa aaatcaaggc   720
tacatctctg ctgaacagta tgagaaagca gtcaatacac caattactga tggactacaa   780
agtctcaaat cagcaagtaa ttaccctgct tacatggata attacctcaa ggaagtcatc   840
aatcaagttg aagaagaaac aggctataac ctactcacaa ctgggatgga tgtctacaca   900
aatgtagacc aagaagctca aaaacatctg tgggatattt acaatacaga cgaatacgtt   960
gcctatccag acgatgaatt gcaagtcgct tctaccattg ttgatgtttc taacggtaaa   1020
gtcattgccc agctaggagc acgccatcag tcaagtaatg tttccttcgg aattaaccaa   1080
gcagtagaaa caaaccgcga ctggggatca actatgaaac cgatcacaga ctatgctcct   1140
gccttggagt acggtgtcta cgattcaact gctactatcg ttcacgatga gccctataac   1200
taccctggga caaatactcc tgtttataac tgggataggg gctactttgg caacatcacc   1260
ttgcaatacg ccctgcaaca atcgcgaaac gtcccagccg tggaaactct aaacaaggtc   1320
ggactcaacc gcgccaagac tttcctaaat ggtctaggaa tcgactaccc aagtattcac   1380
tactcaaatg ccatttcaag taacacaacc gaatcagaca aaaaatatgg agcaagtagt   1440
gaaaagatgg ctgctgctta cgctgccttt gcaaatggtg gaacttacta taaaccaatg   1500
tatatccata aagtcgtctt tagtgatggg agtgaaaaag agttctctaa tgtcggaact   1560
cgtgccatga aggaaacgac agcctatatg atgaccgaca tgatgaaaac agtcttgact   1620
tatggaactg gacgaaatgc ctatcttgct tggctccctc aggctggtaa aacaggaacc   1680
tctaactata cagacgagga aattgaaaac cacatcaaga cctctcaatt tgtagcacct   1740
gatgaactat ttgctggcta tacgcgtaaa tattcaatgg ctgtatggac aggctattct   1800
aaccgtctga caccacttgt aggcaatggc cttacggtcg ctgccaaagt ttaccgctct   1860
atgatgacct acctgtctga aggaagcaat ccagaagatt ggaatatacc agaggggctc   1920
tacagaaatg gagaattcgt atttaaaaat ggtgctcgtt ctacgtggaa ctcacctgct   1980
ccacaacaac ccccatcaac tgaaagttca agctcatcat cagatagttc aacttcacag   2040
tctagctcaa ccactccaag cacaaataat agtacgacta ccaatcctaa caataatacg   2100
caacaatcaa atacaacccc tgatcaacaa aatcagaatc ctcaaccagc acaacca      2157

<210>   574
<211>   719
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   penicillin-binding protein 1A (pbp1A)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902373 (0.E+01)

<400>   574
Met Asn Lys Pro Thr Ile Leu Arg Leu Ile Lys Tyr Leu Ser Ile Ser 
1               5                   10                  15      

Phe Leu Ser Leu Val Ile Ala Ala Ile Val Leu Gly Gly Gly Val Phe 
            20                  25                  30          

Phe Tyr Tyr Val Ser Lys Ala Pro Ser Leu Ser Glu Ser Lys Leu Val 
        35                  40                  45              

Ala Thr Thr Ser Ser Lys Ile Tyr Asp Asn Lys Asn Gln Leu Ile Ala 
    50                  55                  60                  

Asp Leu Gly Ser Glu Arg Arg Val Asn Ala Gln Ala Asn Asp Ile Pro 
65                  70                  75                  80  

Thr Asp Leu Val Lys Ala Ile Val Ser Ile Glu Asp His Arg Phe Phe 
                85                  90                  95      

Asp His Arg Gly Ile Asp Thr Ile Arg Ile Leu Gly Ala Phe Leu Arg 
            100                 105                 110         

Asn Leu Gln Ser Asn Ser Leu Gln Gly Gly Ser Thr Leu Thr Gln Gln 
        115                 120                 125             

Leu Ile Lys Leu Thr Tyr Phe Ser Thr Ser Thr Ser Asp Gln Thr Ile 
    130                 135                 140                 

Ser Arg Lys Ala Gln Glu Ala Trp Leu Ala Ile Gln Leu Glu Gln Lys 
145                 150                 155                 160 

Ala Thr Lys Gln Glu Ile Leu Thr Tyr Tyr Ile Asn Lys Val Tyr Met 
                165                 170                 175     

Ser Asn Gly Asn Tyr Gly Met Gln Thr Ala Ala Gln Asn Tyr Tyr Gly 
            180                 185                 190         

Lys Asp Leu Asn Asn Leu Ser Leu Pro Gln Leu Ala Leu Leu Ala Gly 
        195                 200                 205             

Met Pro Gln Ala Pro Asn Gln Tyr Asp Pro Tyr Ser His Pro Glu Ala 
    210                 215                 220                 

Ala Gln Asp Arg Arg Asn Leu Val Leu Ser Glu Met Lys Asn Gln Gly 
225                 230                 235                 240 

Tyr Ile Ser Ala Glu Gln Tyr Glu Lys Ala Val Asn Thr Pro Ile Thr 
                245                 250                 255     

Asp Gly Leu Gln Ser Leu Lys Ser Ala Ser Asn Tyr Pro Ala Tyr Met 
            260                 265                 270         

Asp Asn Tyr Leu Lys Glu Val Ile Asn Gln Val Glu Glu Glu Thr Gly 
        275                 280                 285             

Tyr Asn Leu Leu Thr Thr Gly Met Asp Val Tyr Thr Asn Val Asp Gln 
    290                 295                 300                 

Glu Ala Gln Lys His Leu Trp Asp Ile Tyr Asn Thr Asp Glu Tyr Val 
305                 310                 315                 320 

Ala Tyr Pro Asp Asp Glu Leu Gln Val Ala Ser Thr Ile Val Asp Val 
                325                 330                 335     

Ser Asn Gly Lys Val Ile Ala Gln Leu Gly Ala Arg His Gln Ser Ser 
            340                 345                 350         

Asn Val Ser Phe Gly Ile Asn Gln Ala Val Glu Thr Asn Arg Asp Trp 
        355                 360                 365             

Gly Ser Thr Met Lys Pro Ile Thr Asp Tyr Ala Pro Ala Leu Glu Tyr 
    370                 375                 380                 

Gly Val Tyr Asp Ser Thr Ala Thr Ile Val His Asp Glu Pro Tyr Asn 
385                 390                 395                 400 

Tyr Pro Gly Thr Asn Thr Pro Val Tyr Asn Trp Asp Arg Gly Tyr Phe 
                405                 410                 415     

Gly Asn Ile Thr Leu Gln Tyr Ala Leu Gln Gln Ser Arg Asn Val Pro 
            420                 425                 430         

Ala Val Glu Thr Leu Asn Lys Val Gly Leu Asn Arg Ala Lys Thr Phe 
        435                 440                 445             

Leu Asn Gly Leu Gly Ile Asp Tyr Pro Ser Ile His Tyr Ser Asn Ala 
    450                 455                 460                 

Ile Ser Ser Asn Thr Thr Glu Ser Asp Lys Lys Tyr Gly Ala Ser Ser 
465                 470                 475                 480 

Glu Lys Met Ala Ala Ala Tyr Ala Ala Phe Ala Asn Gly Gly Thr Tyr 
                485                 490                 495     

Tyr Lys Pro Met Tyr Ile His Lys Val Val Phe Ser Asp Gly Ser Glu 
            500                 505                 510         

Lys Glu Phe Ser Asn Val Gly Thr Arg Ala Met Lys Glu Thr Thr Ala 
        515                 520                 525             

Tyr Met Met Thr Asp Met Met Lys Thr Val Leu Thr Tyr Gly Thr Gly 
    530                 535                 540                 

Arg Asn Ala Tyr Leu Ala Trp Leu Pro Gln Ala Gly Lys Thr Gly Thr 
545                 550                 555                 560 

Ser Asn Tyr Thr Asp Glu Glu Ile Glu Asn His Ile Lys Thr Ser Gln 
                565                 570                 575     

Phe Val Ala Pro Asp Glu Leu Phe Ala Gly Tyr Thr Arg Lys Tyr Ser 
            580                 585                 590         

Met Ala Val Trp Thr Gly Tyr Ser Asn Arg Leu Thr Pro Leu Val Gly 
        595                 600                 605             

Asn Gly Leu Thr Val Ala Ala Lys Val Tyr Arg Ser Met Met Thr Tyr 
    610                 615                 620                 

Leu Ser Glu Gly Ser Asn Pro Glu Asp Trp Asn Ile Pro Glu Gly Leu 
625                 630                 635                 640 

Tyr Arg Asn Gly Glu Phe Val Phe Lys Asn Gly Ala Arg Ser Thr Trp 
                645                 650                 655     

Asn Ser Pro Ala Pro Gln Gln Pro Pro Ser Thr Glu Ser Ser Ser Ser 
            660                 665                 670         

Ser Ser Asp Ser Ser Thr Ser Gln Ser Ser Ser Thr Thr Pro Ser Thr 
        675                 680                 685             

Asn Asn Ser Thr Thr Thr Asn Pro Asn Asn Asn Thr Gln Gln Ser Asn 
    690                 695                 700                 

Thr Thr Pro Asp Gln Gln Asn Gln Asn Pro Gln Pro Ala Gln Pro 
705                 710                 715                 

<210>   575
<211>   594
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   575
atggtcaact atccacataa agtttcatca caaaaaagac aaacatctct ttctcaaccc   60
aaaaatttcg caaatcgagg aatgtctttt gaaaagatga tcaatgctac caacgactac   120
tatttgtctc agggcttggc tgttatacat aagaaaccaa ctcctattca aatcgtacaa   180
gtggactatc cacaacgaag tcgtgccaag attgttgaag cctattttcg acaagcttca   240
acgacggact attctggcgt ttataatgga tattacatcg actttgaagt caaggaaaca   300
aaacaaaaac gtgcgattcc gatgaaaaat tttcatccac atcagattca gcatatggaa   360
caagtccttg cccaacaagg aatctgcttt gtccttcttc acttttcttc tcagcaagaa   420
acctacttat tgccggcatt cgatttgatt cgcttctatc atcaagataa gggacaaaaa   480
tcaatgccac ttgaatatat tcgagaatat ggatatgaaa tcaaggctgg tgccttccct   540
caaattcctt atctcaatgt tatcaaagaa catttattag gtggtaaaac aaga         594

<210>   576
<211>   198
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   recombination protein U (recU)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902374 (e-115)

<400>   576
Met Val Asn Tyr Pro His Lys Val Ser Ser Gln Lys Arg Gln Thr Ser 
1               5                   10                  15      

Leu Ser Gln Pro Lys Asn Phe Ala Asn Arg Gly Met Ser Phe Glu Lys 
            20                  25                  30          

Met Ile Asn Ala Thr Asn Asp Tyr Tyr Leu Ser Gln Gly Leu Ala Val 
        35                  40                  45              

Ile His Lys Lys Pro Thr Pro Ile Gln Ile Val Gln Val Asp Tyr Pro 
    50                  55                  60                  

Gln Arg Ser Arg Ala Lys Ile Val Glu Ala Tyr Phe Arg Gln Ala Ser 
65                  70                  75                  80  

Thr Thr Asp Tyr Ser Gly Val Tyr Asn Gly Tyr Tyr Ile Asp Phe Glu 
                85                  90                  95      

Val Lys Glu Thr Lys Gln Lys Arg Ala Ile Pro Met Lys Asn Phe His 
            100                 105                 110         

Pro His Gln Ile Gln His Met Glu Gln Val Leu Ala Gln Gln Gly Ile 
        115                 120                 125             

Cys Phe Val Leu Leu His Phe Ser Ser Gln Gln Glu Thr Tyr Leu Leu 
    130                 135                 140                 

Pro Ala Phe Asp Leu Ile Arg Phe Tyr His Gln Asp Lys Gly Gln Lys 
145                 150                 155                 160 

Ser Met Pro Leu Glu Tyr Ile Arg Glu Tyr Gly Tyr Glu Ile Lys Ala 
                165                 170                 175     

Gly Ala Phe Pro Gln Ile Pro Tyr Leu Asn Val Ile Lys Glu His Leu 
            180                 185                 190         

Leu Gly Gly Lys Thr Arg 
        195             

<210>   577
<211>   525
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   577
atggctacag ctttggtttt aggctattct gcttttgatt tgggtttatt ttctgataag   60
gatcctcgtc ttaaattgat taaaaaagcg atacgtaaag atttagaggc tatggcagca   120
gatggggtgt cttggcttgt gtttacaggg agtttgggtt ttgaatattg ggttttagag   180
gttgctcagg agatgaaaac tgaatacggt ttccagttgg ccaccatttt tgcttttgaa   240
acccatgggg aaaattggaa tgaaggcaat cagatgaaac tgagtcgctt taagcaggta   300
gactttgtca aatatgccta tcctcgctat gaacacaagg ggcagttaag agattaccag   360
cagtttttgc tggaaaacac gactagttcc tatctttttt atgatgaaga aaatgaaaca   420
aaactagctt atttttacca aaagatgaaa aatcaagagg actattttat aaagagatta   480

acatttgatg aattaaatga acttgctgaa aatttttccg aaaat                   525

<210>   578
<211>   175
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902375 (e-100)

<400>   578
Met Ala Thr Ala Leu Val Leu Gly Tyr Ser Ala Phe Asp Leu Gly Leu 
1               5                   10                  15      

Phe Ser Asp Lys Asp Pro Arg Leu Lys Leu Ile Lys Lys Ala Ile Arg 
            20                  25                  30          

Lys Asp Leu Glu Ala Met Ala Ala Asp Gly Val Ser Trp Leu Val Phe 
        35                  40                  45              

Thr Gly Ser Leu Gly Phe Glu Tyr Trp Val Leu Glu Val Ala Gln Glu 
    50                  55                  60                  

Met Lys Thr Glu Tyr Gly Phe Gln Leu Ala Thr Ile Phe Ala Phe Glu 
65                  70                  75                  80  

Thr His Gly Glu Asn Trp Asn Glu Gly Asn Gln Met Lys Leu Ser Arg 
                85                  90                  95      

Phe Lys Gln Val Asp Phe Val Lys Tyr Ala Tyr Pro Arg Tyr Glu His 
            100                 105                 110         

Lys Gly Gln Leu Arg Asp Tyr Gln Gln Phe Leu Leu Glu Asn Thr Thr 
        115                 120                 125             

Ser Ser Tyr Leu Phe Tyr Asp Glu Glu Asn Glu Thr Lys Leu Ala Tyr 
    130                 135                 140                 

Phe Tyr Gln Lys Met Lys Asn Gln Glu Asp Tyr Phe Ile Lys Arg Leu 
145                 150                 155                 160 

Thr Phe Asp Glu Leu Asn Glu Leu Ala Glu Asn Phe Ser Glu Asn 
                165                 170                 175 

<210>   579
<211>   327
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   579
atggcaagta ttattttttc agcgaaagat atttttgaac aagagtttgg acgtgaggtc   60
cgtggctata ataaagtaga agttgacgag tttttagacg atgtcatcaa ggactatgaa   120
acctatgctg ccttggtcaa gtcacttcgt caggaaattg cggatttgaa ggaagaatta   180
actcgtaaac cgaaaccttc accagttcaa gcagaacccc ttgaagcggc aattacaagt   240
tctatgacga attttgatat tttgaaacgc ctgaatagat tggaaaaaga agtttttggt   300
aaacaaattt tagataactc agatttt                                       327

<210>   580
<211>   109
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902376 (2.E-57)

<400>   580
Met Ala Ser Ile Ile Phe Ser Ala Lys Asp Ile Phe Glu Gln Glu Phe 
1               5                   10                  15      

Gly Arg Glu Val Arg Gly Tyr Asn Lys Val Glu Val Asp Glu Phe Leu 
            20                  25                  30          

Asp Asp Val Ile Lys Asp Tyr Glu Thr Tyr Ala Ala Leu Val Lys Ser 
        35                  40                  45              

Leu Arg Gln Glu Ile Ala Asp Leu Lys Glu Glu Leu Thr Arg Lys Pro 
    50                  55                  60                  

Lys Pro Ser Pro Val Gln Ala Glu Pro Leu Glu Ala Ala Ile Thr Ser 
65                  70                  75                  80  

Ser Met Thr Asn Phe Asp Ile Leu Lys Arg Leu Asn Arg Leu Glu Lys 
                85                  90                  95      

Glu Val Phe Gly Lys Gln Ile Leu Asp Asn Ser Asp Phe 
            100                 105                 

<210>   581
<211>   1155
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   581
atgaaaaaag aatttaattt aattgcaact gtggcagcag ggcttgaggc tgtcgttggt   60
cgtgaagtgc gagagttggg ctacgattgt caggttgaaa atggacgtgt tcgttttcaa   120
ggagacgtga gagctattat cgaaaccaac ctttggcttc gggcagcaga tcgtatcaaa   180
attatcgtag gaacgttccc agctaagact tttgaagagc tatttcaggg agttttcgct   240
ttggattggg aaaattattt accacttgga gctcggttcc cgatttcaaa agctaaatgt   300
gttaagtcca aacttcacaa tgagcccagt gttcaggcta tttctaagaa agctgttgtc   360
aagaaattgc agaaacacta tgctcgccca gaaggggttc ctctgatgga gaatggccca   420
gagtttaaga ttgaggtctc tattctcaaa gatgtggcaa ctgtcatgat tgatacgacc   480
gggtctagcc tctttaaacg tggttatcgt accgaaaaag gtggcgctcc tatcaaggaa   540
aatatggcag cagccatttt acaactttct aactggtatc cagacaagcc tttgattgat   600
ccgacctgtg gttcggggac tttctgtatt gaggcagtta tgattgctag aaagatggcg   660
ccaggtcttc gtcgctcttt tgcatttgag gaatggaact ggatcagcga tcgcttgatt   720
caagaagtgc gcacagaagc ggctaaaaaa gtagaccgtg agcttgagct ggatatcatg   780
ggctgtgata ttgatgctcg catggtggaa attgctaagg ccaatgctca ggtagctggt   840
gttgcaggag acattacttt taagcagatg cgcgtgcagg atttacgttc cgataaaatc   900
aatggagtaa tcatttccaa tccgccttat ggtgaacgtt tgtcagatga tgcaggggtg   960
accaagctct atgctgagat ggggcaagta tttgcaccgc tgaaaacttg gagcaaattt   1020
atcctgacta gtgatgaagc ttttgaaagc aagtatggta gccaagcaga taagaagcgt   1080
aagttataca acggaacctt gaaagtggat ctatatcaat attttggtca gcgtgtcaaa   1140
cggcaagagg taaaa                                                    1155

<210>   582
<211>   385
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902377 (0.E+01)

<400>   582
Met Lys Lys Glu Phe Asn Leu Ile Ala Thr Val Ala Ala Gly Leu Glu 
1               5                   10                  15      

Ala Val Val Gly Arg Glu Val Arg Glu Leu Gly Tyr Asp Cys Gln Val 
            20                  25                  30          

Glu Asn Gly Arg Val Arg Phe Gln Gly Asp Val Arg Ala Ile Ile Glu 
        35                  40                  45              

Thr Asn Leu Trp Leu Arg Ala Ala Asp Arg Ile Lys Ile Ile Val Gly 
    50                  55                  60                  

Thr Phe Pro Ala Lys Thr Phe Glu Glu Leu Phe Gln Gly Val Phe Ala 
65                  70                  75                  80  

Leu Asp Trp Glu Asn Tyr Leu Pro Leu Gly Ala Arg Phe Pro Ile Ser 
                85                  90                  95      

Lys Ala Lys Cys Val Lys Ser Lys Leu His Asn Glu Pro Ser Val Gln 
            100                 105                 110         

Ala Ile Ser Lys Lys Ala Val Val Lys Lys Leu Gln Lys His Tyr Ala 
        115                 120                 125             

Arg Pro Glu Gly Val Pro Leu Met Glu Asn Gly Pro Glu Phe Lys Ile 
    130                 135                 140                 

Glu Val Ser Ile Leu Lys Asp Val Ala Thr Val Met Ile Asp Thr Thr 
145                 150                 155                 160 

Gly Ser Ser Leu Phe Lys Arg Gly Tyr Arg Thr Glu Lys Gly Gly Ala 
                165                 170                 175     

Pro Ile Lys Glu Asn Met Ala Ala Ala Ile Leu Gln Leu Ser Asn Trp 
            180                 185                 190         

Tyr Pro Asp Lys Pro Leu Ile Asp Pro Thr Cys Gly Ser Gly Thr Phe 
        195                 200                 205             

Cys Ile Glu Ala Val Met Ile Ala Arg Lys Met Ala Pro Gly Leu Arg 
    210                 215                 220                 

Arg Ser Phe Ala Phe Glu Glu Trp Asn Trp Ile Ser Asp Arg Leu Ile 
225                 230                 235                 240 

Gln Glu Val Arg Thr Glu Ala Ala Lys Lys Val Asp Arg Glu Leu Glu 
                245                 250                 255     

Leu Asp Ile Met Gly Cys Asp Ile Asp Ala Arg Met Val Glu Ile Ala 
            260                 265                 270         

Lys Ala Asn Ala Gln Val Ala Gly Val Ala Gly Asp Ile Thr Phe Lys 
        275                 280                 285             

Gln Met Arg Val Gln Asp Leu Arg Ser Asp Lys Ile Asn Gly Val Ile 
    290                 295                 300                 

Ile Ser Asn Pro Pro Tyr Gly Glu Arg Leu Ser Asp Asp Ala Gly Val 
305                 310                 315                 320 

Thr Lys Leu Tyr Ala Glu Met Gly Gln Val Phe Ala Pro Leu Lys Thr 
                325                 330                 335     

Trp Ser Lys Phe Ile Leu Thr Ser Asp Glu Ala Phe Glu Ser Lys Tyr 
            340                 345                 350         

Gly Ser Gln Ala Asp Lys Lys Arg Lys Leu Tyr Asn Gly Thr Leu Lys 
        355                 360                 365             

Val Asp Leu Tyr Gln Tyr Phe Gly Gln Arg Val Lys Arg Gln Glu Val 
    370                 375                 380                 

Lys 
385 

<210>   583
<211>   1392
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   583
atgagtaaaa aaagacgaaa tcgtcataaa aaagaaggtc aagaaccgca atttgatttt   60
gatgaagcaa aagagctaac agttggtcaa gctattcgta aaaatgaaga agtggaatca   120
ggagtcttgc ctgaggattc cattttggac aagtatgtta agcaacacag agatgaaatt   180
gaggcggata agtttgcgac tcgtcaatac aaaaaagagg agttcgttga aactcagagt   240
ctggatgatt taattcaaga gatgcgtgag gctgtagaga agtcagaagc ttcttcggag   300
gaagttccat cttctgaaga catcttacta cccttgcctc tggacgatga ggagcaaggc   360
ttggatcctc tattgctaga tgatgaaaat ccaacagaaa tgactgaaga agtggaagag   420
gagcaaaacc tttctcgtct ggatcaagag gactcagaaa agaaaagtaa aaaaggcttt   480
attttgaccg ttttggcgct tgtatcagta attatttgtg tcagtgctta ttatgtctac   540
cgtcaagtgg ctcgttcgac taaggaaatt gaaacttctc aatcaactac agccaatcaa   600
tcggatgtgg atgattttaa tacactttat gacgcctttt acacagatag caataaaacg   660
gctttgaaaa atagccagtt tgataaactg agtcaactca agactttact tgataagctg   720
gaaggtagtc gtgaacatac gcttgccaaa tctaaatatg atagtctagc aacgcaaatc   780
aaggctattc aagatgtcaa tgctcaattt gagaaaccag ctattgtgga tggtgtgttg   840
gataccaatg ccaaagccaa atcggatgct aaatttacgg atattaaaac tggaaatacg   900
gagcttgata aagtgctaga taaggctatc agtcttggta agagccagca aacaagtact   960
tctagctcaa gttcaagtca aactagcagc tcaagttcaa gtcaagcaag ttcaaatacg   1020
actagtgagc caaaaccaag tagttcaaat gagactagaa gtagtcgcag tgaagtcaat   1080
atgggtctct cgagtgcagg ggttgctgtt caaagaagtg ccagtcgtgt tgcctataat   1140
cagtctgcta ttgatgatag taataactct gcctgggatt ttgcggatgg tgtcttggaa   1200
caaattctag cgacttcacg ttcacgtggc tatatcactg gagaccaata tatccttgaa   1260
cgtgtcaata tcgttaacgg caatggttat tacaacctct acaagccaga tggaacctat   1320
ctctttaccc ttaactgtaa gacaggctac tttgtcggaa atggcgctgg tcatgcggat   1380
gacttagatt ac                                                       1392

<210>   584
<211>   464
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902378 (0.E+01)

<400>   584
Met Ser Lys Lys Arg Arg Asn Arg His Lys Lys Glu Gly Gln Glu Pro 
1               5                   10                  15      

Gln Phe Asp Phe Asp Glu Ala Lys Glu Leu Thr Val Gly Gln Ala Ile 
            20                  25                  30          

Arg Lys Asn Glu Glu Val Glu Ser Gly Val Leu Pro Glu Asp Ser Ile 
        35                  40                  45              

Leu Asp Lys Tyr Val Lys Gln His Arg Asp Glu Ile Glu Ala Asp Lys 
    50                  55                  60                  

Phe Ala Thr Arg Gln Tyr Lys Lys Glu Glu Phe Val Glu Thr Gln Ser 
65                  70                  75                  80  

Leu Asp Asp Leu Ile Gln Glu Met Arg Glu Ala Val Glu Lys Ser Glu 
                85                  90                  95      

Ala Ser Ser Glu Glu Val Pro Ser Ser Glu Asp Ile Leu Leu Pro Leu 
            100                 105                 110         

Pro Leu Asp Asp Glu Glu Gln Gly Leu Asp Pro Leu Leu Leu Asp Asp 
        115                 120                 125             

Glu Asn Pro Thr Glu Met Thr Glu Glu Val Glu Glu Glu Gln Asn Leu 
    130                 135                 140                 

Ser Arg Leu Asp Gln Glu Asp Ser Glu Lys Lys Ser Lys Lys Gly Phe 
145                 150                 155                 160 

Ile Leu Thr Val Leu Ala Leu Val Ser Val Ile Ile Cys Val Ser Ala 
                165                 170                 175     

Tyr Tyr Val Tyr Arg Gln Val Ala Arg Ser Thr Lys Glu Ile Glu Thr 
            180                 185                 190         

Ser Gln Ser Thr Thr Ala Asn Gln Ser Asp Val Asp Asp Phe Asn Thr 
        195                 200                 205             

Leu Tyr Asp Ala Phe Tyr Thr Asp Ser Asn Lys Thr Ala Leu Lys Asn 
    210                 215                 220                 

Ser Gln Phe Asp Lys Leu Ser Gln Leu Lys Thr Leu Leu Asp Lys Leu 
225                 230                 235                 240 

Glu Gly Ser Arg Glu His Thr Leu Ala Lys Ser Lys Tyr Asp Ser Leu 
                245                 250                 255     

Ala Thr Gln Ile Lys Ala Ile Gln Asp Val Asn Ala Gln Phe Glu Lys 
            260                 265                 270         

Pro Ala Ile Val Asp Gly Val Leu Asp Thr Asn Ala Lys Ala Lys Ser 
        275                 280                 285             

Asp Ala Lys Phe Thr Asp Ile Lys Thr Gly Asn Thr Glu Leu Asp Lys 
    290                 295                 300                 

Val Leu Asp Lys Ala Ile Ser Leu Gly Lys Ser Gln Gln Thr Ser Thr 
305                 310                 315                 320 

Ser Ser Ser Ser Ser Ser Gln Thr Ser Ser Ser Ser Ser Ser Gln Ala 
                325                 330                 335     

Ser Ser Asn Thr Thr Ser Glu Pro Lys Pro Ser Ser Ser Asn Glu Thr 
            340                 345                 350         

Arg Ser Ser Arg Ser Glu Val Asn Met Gly Leu Ser Ser Ala Gly Val 
        355                 360                 365             

Ala Val Gln Arg Ser Ala Ser Arg Val Ala Tyr Asn Gln Ser Ala Ile 
    370                 375                 380                 

Asp Asp Ser Asn Asn Ser Ala Trp Asp Phe Ala Asp Gly Val Leu Glu 
385                 390                 395                 400 

Gln Ile Leu Ala Thr Ser Arg Ser Arg Gly Tyr Ile Thr Gly Asp Gln 
                405                 410                 415     

Tyr Ile Leu Glu Arg Val Asn Ile Val Asn Gly Asn Gly Tyr Tyr Asn 
            420                 425                 430         

Leu Tyr Lys Pro Asp Gly Thr Tyr Leu Phe Thr Leu Asn Cys Lys Thr 
        435                 440                 445             

Gly Tyr Phe Val Gly Asn Gly Ala Gly His Ala Asp Asp Leu Asp Tyr 
    450                 455                 460                 


<210>   585
<211>   1422
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   585
atgacaaaag ctaactttgg tgtcgtaggt atggccgtaa tgggtcgtaa ccttgccctt   60
aatattgaat ctcgtggtta cacagttgct atctacaacc gtagtaaaga aaaaacggaa   120
gatgtgattg cttgccatcc tgaaaagaac tttgtaccaa gctatgacgt tgaaagtttt   180
gtaaactcaa tcgaaaaacc tcgtcgtatc atgctgatgg ttcaagctgg acctggtaca   240
gatgctacta tccaagccct tcttccacac cttgacaagg gtgatatctt gattgacgga   300
ggaaatactt tctacaaaga taccatccgt cgtaatgaag aattggcaaa ctctggtatc   360
aactttatcg gtactggggt ttctggtggt gaaaaaggtg cccttgaagg tccttctatc   420
atgcctggtg gacaaaaaga agcctacgaa ttggttgcgg atgttcttga agaaatctca   480
gctaaagcac cagaagatgg caaaccatgt gtgacttaca tcggtcctga tggagctggt   540
cactatgtga aaatggttca caatggtatt gagtacggtg atatgcaatt gatcgcagaa   600
agctatgact tgatgcaaca cttgctaggc ctttctgcag aagatatggc tgaaatcttt   660
actgagtgga acaagggtga attagacagc tacttgattg aaatcacagc tgatatcttg   720
agccgtaaag acgatgaagg ccaagatgga ccaatcgtag actacatcct tgatgctgca   780
ggtaacaagg gaactggtaa atggactagc caatcatctc ttgaccttgg tgtaccattg   840
tcactgatta ctgagtcagt gtttgcacgc tacatttcaa cttacaaaga agaacgtgta   900
catgctagca aggtgcttcc aaaaccagct gccttcaact ttgaaggaga caaggctgaa   960
ttgattgaaa agatccgtca agccctttac ttctcaaaaa tcatttcata cgcacaagga   1020
tttgctcaat tgcgtgtagc ctctaaagaa aacaactgga acttgccatt tgcagatatc   1080
gcatctatct ggcgtgatgg ctgtatcatc cgttctcgtt tcttgcaaaa gattacagat   1140
gcttacaacc gcgatgcaga tcttgccaac cttcttttgg acgagtactt cttggatgtt   1200
actgctaagt accaacaagc agtacgtgat atcgtagctc ttgcggttca agcaggtgtg   1260
ccagtgccaa ctttctcagc agctattact tactttgata gctaccgttc agctgacctt   1320
ccagctaact tgatccaagc acaacgtgac tactttggtg ctcacactta ccaacgtaaa   1380
gacaaagaag gaaccttcca ctactcttgg tatgacgaaa aa                      1422

<210>   586
<211>   474
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   6-phosphogluconate dehydrogenase, decarboxylating (gnd)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902379 (0.E+01)

<400>   586
Met Thr Lys Ala Asn Phe Gly Val Val Gly Met Ala Val Met Gly Arg 
1               5                   10                  15      

Asn Leu Ala Leu Asn Ile Glu Ser Arg Gly Tyr Thr Val Ala Ile Tyr 
            20                  25                  30          

Asn Arg Ser Lys Glu Lys Thr Glu Asp Val Ile Ala Cys His Pro Glu 
        35                  40                  45              

Lys Asn Phe Val Pro Ser Tyr Asp Val Glu Ser Phe Val Asn Ser Ile 
    50                  55                  60                  

Glu Lys Pro Arg Arg Ile Met Leu Met Val Gln Ala Gly Pro Gly Thr 
65                  70                  75                  80  

Asp Ala Thr Ile Gln Ala Leu Leu Pro His Leu Asp Lys Gly Asp Ile 
                85                  90                  95      

Leu Ile Asp Gly Gly Asn Thr Phe Tyr Lys Asp Thr Ile Arg Arg Asn 
            100                 105                 110         

Glu Glu Leu Ala Asn Ser Gly Ile Asn Phe Ile Gly Thr Gly Val Ser 
        115                 120                 125             

Gly Gly Glu Lys Gly Ala Leu Glu Gly Pro Ser Ile Met Pro Gly Gly 
    130                 135                 140                 

Gln Lys Glu Ala Tyr Glu Leu Val Ala Asp Val Leu Glu Glu Ile Ser 
145                 150                 155                 160 

Ala Lys Ala Pro Glu Asp Gly Lys Pro Cys Val Thr Tyr Ile Gly Pro 
                165                 170                 175     

Asp Gly Ala Gly His Tyr Val Lys Met Val His Asn Gly Ile Glu Tyr 
            180                 185                 190         

Gly Asp Met Gln Leu Ile Ala Glu Ser Tyr Asp Leu Met Gln His Leu 
        195                 200                 205             

Leu Gly Leu Ser Ala Glu Asp Met Ala Glu Ile Phe Thr Glu Trp Asn 
    210                 215                 220                 

Lys Gly Glu Leu Asp Ser Tyr Leu Ile Glu Ile Thr Ala Asp Ile Leu 
225                 230                 235                 240 

Ser Arg Lys Asp Asp Glu Gly Gln Asp Gly Pro Ile Val Asp Tyr Ile 
                245                 250                 255     

Leu Asp Ala Ala Gly Asn Lys Gly Thr Gly Lys Trp Thr Ser Gln Ser 
            260                 265                 270         

Ser Leu Asp Leu Gly Val Pro Leu Ser Leu Ile Thr Glu Ser Val Phe 
        275                 280                 285             

Ala Arg Tyr Ile Ser Thr Tyr Lys Glu Glu Arg Val His Ala Ser Lys 
    290                 295                 300                 

Val Leu Pro Lys Pro Ala Ala Phe Asn Phe Glu Gly Asp Lys Ala Glu 
305                 310                 315                 320 

Leu Ile Glu Lys Ile Arg Gln Ala Leu Tyr Phe Ser Lys Ile Ile Ser 
                325                 330                 335     

Tyr Ala Gln Gly Phe Ala Gln Leu Arg Val Ala Ser Lys Glu Asn Asn 
            340                 345                 350         

Trp Asn Leu Pro Phe Ala Asp Ile Ala Ser Ile Trp Arg Asp Gly Cys 
        355                 360                 365             

Ile Ile Arg Ser Arg Phe Leu Gln Lys Ile Thr Asp Ala Tyr Asn Arg 
    370                 375                 380                 

Asp Ala Asp Leu Ala Asn Leu Leu Leu Asp Glu Tyr Phe Leu Asp Val 
385                 390                 395                 400 

Thr Ala Lys Tyr Gln Gln Ala Val Arg Asp Ile Val Ala Leu Ala Val 
                405                 410                 415     

Gln Ala Gly Val Pro Val Pro Thr Phe Ser Ala Ala Ile Thr Tyr Phe 
            420                 425                 430         

Asp Ser Tyr Arg Ser Ala Asp Leu Pro Ala Asn Leu Ile Gln Ala Gln 
        435                 440                 445             

Arg Asp Tyr Phe Gly Ala His Thr Tyr Gln Arg Lys Asp Lys Glu Gly 
    450                 455                 460                 

Thr Phe His Tyr Ser Trp Tyr Asp Glu Lys 
465                 470                 

<210>   587
<211>   687
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   587
atggggaaac ggattttatt acttgagaaa gaacgaaatc tagctcattt tttaagtttg   60
gaactccaga aagagcagta tcgggttgat ctggtagagg aggggcaaaa agccctctcc   120
atggctcttc agacagacta tgatttgatg ttattgaacg ttaatctggg agatatgatg   180
gctcaggatt ttgcagaaaa attgagccga actaaacctg cctcagtcat catgatttta   240
gatcattggg aagacttgca agaagagctg gaagttgttc agcgttttgc agtttcatac   300
atctataagc cagtccttat cgaaaatctg gtagcgcgta tttcggcgat cttccgaggt   360
cgggacttca ttgatcaaca ctgcagtctg atgaaagttc caaggaccta ccgcaatctt   420
aggatagatg ttgaacatca cacggtttat cgtggtgaag agatgattgc tctgacacgc   480
cgtgagtatg accttttggc gacacttatg ggaagcaaga aagtattgac tcgtgagcaa   540
ttgttggaaa gtgtttggaa gtatgaaagt gcgaccgaga caaatatcgt agatgtctat   600
atccgctatc tacggagcaa gcttgatgtt aaaggccaaa aaagctacat taaaactgtg   660
cgtggtgttg gatataccat gcaagaa                                       687

<210>   588
<211>   229
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902380 (e-127)

<400>   588
Met Gly Lys Arg Ile Leu Leu Leu Glu Lys Glu Arg Asn Leu Ala His 
1               5                   10                  15      

Phe Leu Ser Leu Glu Leu Gln Lys Glu Gln Tyr Arg Val Asp Leu Val 
            20                  25                  30          

Glu Glu Gly Gln Lys Ala Leu Ser Met Ala Leu Gln Thr Asp Tyr Asp 
        35                  40                  45              

Leu Met Leu Leu Asn Val Asn Leu Gly Asp Met Met Ala Gln Asp Phe 
    50                  55                  60                  

Ala Glu Lys Leu Ser Arg Thr Lys Pro Ala Ser Val Ile Met Ile Leu 
65                  70                  75                  80  

Asp His Trp Glu Asp Leu Gln Glu Glu Leu Glu Val Val Gln Arg Phe 
                85                  90                  95      

Ala Val Ser Tyr Ile Tyr Lys Pro Val Leu Ile Glu Asn Leu Val Ala 
            100                 105                 110         

Arg Ile Ser Ala Ile Phe Arg Gly Arg Asp Phe Ile Asp Gln His Cys 
        115                 120                 125             

Ser Leu Met Lys Val Pro Arg Thr Tyr Arg Asn Leu Arg Ile Asp Val 
    130                 135                 140                 

Glu His His Thr Val Tyr Arg Gly Glu Glu Met Ile Ala Leu Thr Arg 
145                 150                 155                 160 

Arg Glu Tyr Asp Leu Leu Ala Thr Leu Met Gly Ser Lys Lys Val Leu 
                165                 170                 175     

Thr Arg Glu Gln Leu Leu Glu Ser Val Trp Lys Tyr Glu Ser Ala Thr 
            180                 185                 190         

Glu Thr Asn Ile Val Asp Val Tyr Ile Arg Tyr Leu Arg Ser Lys Leu 
        195                 200                 205             

Asp Val Lys Gly Gln Lys Ser Tyr Ile Lys Thr Val Arg Gly Val Gly 
    210                 215                 220                 

Tyr Thr Met Gln Glu 
225                 

<210>   589
<211>   1110
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   589
ttgcagttgt gtaactgctt ttttgaggag tttttatata ttgacataca atctagtttt   60
tactacaatc gttttaggag gatatataaa atgaagcttt tgaaaaaaat gatgcaagtc   120
gcattagcag tctttttctt tggtttgcta gctacaaata cggtatttgc gaataccaca   180
ggtggccgat ttgttgataa ggataataga aaatattatg taaaagatga tcataaagca   240
atctattggc ataaaataga cggtaaaact tactattttg gtgatattgg agagatggtt   300
gtcggttggc aatacttaga aattcctgga acaggttatc gtgataattt attcgataac   360
caaccagtta atgaaattgg ccttcaggag aagtggtact attttggaca agatggtgct   420
ttgctagaac aaacagataa acaagtacta gaggcaaaaa cgtctgaaaa tacaggaaaa   480
gtatacggtg aacaatatcc tctatctgct gaaaagagaa cttattattt tgataataat   540
tatgctgtaa agacaggctg gatttatgaa gagggtcatt ggtattattt aaataagcta   600
ggaaattttg gcgatgattc ttacaatcca ctaccaattg gtgaagttgc taagggttgg   660
actcaagatt ttcatgttac tattgacatt gatagaagca aacctgctcc atggtactac   720
ctagatgctt caggtaagat gcttacagat tggcaaaaag taaacggaaa atggtattat   780
tttggctcct ctggttctat ggcaacaggt tggaaatatg tacgaggcaa atggtattac   840
ttagataata aaaatggtga tatgaaaaca ggatggcaat accttggtaa caagtggtac   900
tacctccgtt catcaggagc tatggtaact ggctggtatc aagatggttc aacttggtac   960
tatttagatc cttctaatgg agatatgaaa ataggttgga caaaagtaaa tggaaaatgg   1020
tattatctca attcaaatgg agcaatggtt acaggtagcc aaactatcga tggtaaagtt   1080
tataatttcg cctcatctgg tgagtggatt                                    1110

<210>   590
<211>   370
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline binding protein C (cbpC)
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15902381 (0.E+01)

<400>   590
Met Gln Leu Cys Asn Cys Phe Phe Glu Glu Phe Leu Tyr Ile Asp Ile 
1               5                   10                  15      

Gln Ser Ser Phe Tyr Tyr Asn Arg Phe Arg Arg Ile Tyr Lys Met Lys 
            20                  25                  30          

Leu Leu Lys Lys Met Met Gln Val Ala Leu Ala Val Phe Phe Phe Gly 
        35                  40                  45              

Leu Leu Ala Thr Asn Thr Val Phe Ala Asn Thr Thr Gly Gly Arg Phe 
    50                  55                  60                  

Val Asp Lys Asp Asn Arg Lys Tyr Tyr Val Lys Asp Asp His Lys Ala 
65                  70                  75                  80  

Ile Tyr Trp His Lys Ile Asp Gly Lys Thr Tyr Tyr Phe Gly Asp Ile 
                85                  90                  95      

Gly Glu Met Val Val Gly Trp Gln Tyr Leu Glu Ile Pro Gly Thr Gly 
            100                 105                 110         

Tyr Arg Asp Asn Leu Phe Asp Asn Gln Pro Val Asn Glu Ile Gly Leu 
        115                 120                 125             

Gln Glu Lys Trp Tyr Tyr Phe Gly Gln Asp Gly Ala Leu Leu Glu Gln 
    130                 135                 140                 

Thr Asp Lys Gln Val Leu Glu Ala Lys Thr Ser Glu Asn Thr Gly Lys 
145                 150                 155                 160 

Val Tyr Gly Glu Gln Tyr Pro Leu Ser Ala Glu Lys Arg Thr Tyr Tyr 
                165                 170                 175     

Phe Asp Asn Asn Tyr Ala Val Lys Thr Gly Trp Ile Tyr Glu Glu Gly 
            180                 185                 190         

His Trp Tyr Tyr Leu Asn Lys Leu Gly Asn Phe Gly Asp Asp Ser Tyr 
        195                 200                 205             

Asn Pro Leu Pro Ile Gly Glu Val Ala Lys Gly Trp Thr Gln Asp Phe 
    210                 215                 220                 

His Val Thr Ile Asp Ile Asp Arg Ser Lys Pro Ala Pro Trp Tyr Tyr 
225                 230                 235                 240 

Leu Asp Ala Ser Gly Lys Met Leu Thr Asp Trp Gln Lys Val Asn Gly 
                245                 250                 255     

Lys Trp Tyr Tyr Phe Gly Ser Ser Gly Ser Met Ala Thr Gly Trp Lys 
            260                 265                 270         

Tyr Val Arg Gly Lys Trp Tyr Tyr Leu Asp Asn Lys Asn Gly Asp Met 
        275                 280                 285             

Lys Thr Gly Trp Gln Tyr Leu Gly Asn Lys Trp Tyr Tyr Leu Arg Ser 
    290                 295                 300                 

Ser Gly Ala Met Val Thr Gly Trp Tyr Gln Asp Gly Ser Thr Trp Tyr 
305                 310                 315                 320 

Tyr Leu Asp Pro Ser Asn Gly Asp Met Lys Ile Gly Trp Thr Lys Val 
                325                 330                 335     

Asn Gly Lys Trp Tyr Tyr Leu Asn Ser Asn Gly Ala Met Val Thr Gly 
            340                 345                 350         

Ser Gln Thr Ile Asp Gly Lys Val Tyr Asn Phe Ala Ser Ser Gly Glu 
        355                 360                 365             

Trp Ile 
    370 

<210>   591
<211>   996
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   591
atgaaaattt tgaaaaaaac tatgcaagtt ggactgacag tatttttctt tggtttgcta   60
gggaccagta cagtatttgc agatgattct gaaggatggc agtttgtcca agaaaacgga   120
agaacctact acaaaaaggg ggacctcaaa gaaacctact ggcgagtgat tgatggtaag   180
tactattatt ttgattctct atctggagag atggttgtcg gctggcaata tatcccgttt   240
ccatctaaag gtagtacaat tggtccttac ccaaatggta tcagattaga aggttttcca   300
aagtcagagt ggtactactt cgataaaaat ggagtgctac aagagtttgt tggttggaaa   360
acattagaga ttaaaactaa agacagtgtt ggaagaaagt acggggaaaa acgtgaagat   420
tcagaagata aagaagagaa gcgttattat acgaactatt actttaatca aaatcattct   480
ttagagacag gttggcttta tgatcagtct aactggtatt atctagctaa gacggaaatt   540
aatggagaaa actaccttgg tggtgaaaga cgtgcggggt ggataaacga tgattcgact   600
tggtactacc tagatccaac aactggtatt atgcaaacag gttggcaata tctaggtaat   660
aagtggtact acctccgttc ctcaggagca atggccactg gctggtatca ggaaggtacc   720
acttggtatt atttagacca cccaaatggc gatatgaaaa caggttggca aaaccttggg   780
aacaaatggt actatctccg ttcatcagga gctatggcaa ctggttggta tcaagatggt   840
tcaacttggt actacctaaa tgcaggtaat ggagacatga agacaggttg gttccaggtc   900
aatggcaact ggtactatgc ttatagctca ggtgctttgg cagtgaatac gaccgtagat   960
ggctattctg tcaactataa tggcgaatgg gttcgg                             996

<210>   592
<211>   332
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline binding protein J (cbpJ)
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15902381 (e-109)

<400>   592
Met Lys Ile Leu Lys Lys Thr Met Gln Val Gly Leu Thr Val Phe Phe 
1               5                   10                  15      

Phe Gly Leu Leu Gly Thr Ser Thr Val Phe Ala Asp Asp Ser Glu Gly 
            20                  25                  30          

Trp Gln Phe Val Gln Glu Asn Gly Arg Thr Tyr Tyr Lys Lys Gly Asp 
        35                  40                  45              

Leu Lys Glu Thr Tyr Trp Arg Val Ile Asp Gly Lys Tyr Tyr Tyr Phe 
    50                  55                  60                  

Asp Ser Leu Ser Gly Glu Met Val Val Gly Trp Gln Tyr Ile Pro Phe 
65                  70                  75                  80  

Pro Ser Lys Gly Ser Thr Ile Gly Pro Tyr Pro Asn Gly Ile Arg Leu 
                85                  90                  95      

Glu Gly Phe Pro Lys Ser Glu Trp Tyr Tyr Phe Asp Lys Asn Gly Val 
            100                 105                 110         

Leu Gln Glu Phe Val Gly Trp Lys Thr Leu Glu Ile Lys Thr Lys Asp 
        115                 120                 125             

Ser Val Gly Arg Lys Tyr Gly Glu Lys Arg Glu Asp Ser Glu Asp Lys 
    130                 135                 140                 

Glu Glu Lys Arg Tyr Tyr Thr Asn Tyr Tyr Phe Asn Gln Asn His Ser 
145                 150                 155                 160 

Leu Glu Thr Gly Trp Leu Tyr Asp Gln Ser Asn Trp Tyr Tyr Leu Ala 
                165                 170                 175     

Lys Thr Glu Ile Asn Gly Glu Asn Tyr Leu Gly Gly Glu Arg Arg Ala 
            180                 185                 190         

Gly Trp Ile Asn Asp Asp Ser Thr Trp Tyr Tyr Leu Asp Pro Thr Thr 
        195                 200                 205             

Gly Ile Met Gln Thr Gly Trp Gln Tyr Leu Gly Asn Lys Trp Tyr Tyr 
    210                 215                 220                 

Leu Arg Ser Ser Gly Ala Met Ala Thr Gly Trp Tyr Gln Glu Gly Thr 
225                 230                 235                 240 

Thr Trp Tyr Tyr Leu Asp His Pro Asn Gly Asp Met Lys Thr Gly Trp 
                245                 250                 255     

Gln Asn Leu Gly Asn Lys Trp Tyr Tyr Leu Arg Ser Ser Gly Ala Met 
            260                 265                 270         

Ala Thr Gly Trp Tyr Gln Asp Gly Ser Thr Trp Tyr Tyr Leu Asn Ala 
        275                 280                 285             

Gly Asn Gly Asp Met Lys Thr Gly Trp Phe Gln Val Asn Gly Asn Trp 
    290                 295                 300                 

Tyr Tyr Ala Tyr Ser Ser Gly Ala Leu Ala Val Asn Thr Thr Val Asp 
305                 310                 315                 320 

Gly Tyr Ser Val Asn Tyr Asn Gly Glu Trp Val Arg 
                325                 330         

<210>   593
<211>   1230
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   593
atgaaattat tttggacaaa caacatatat agacagttgc tgctaaacag ctgtttttca   60
tcattcggcg acagtatttt ctacctcgcc attatcaatt atgtggctca gtacaatttc   120
gctccgctag cgattttact gatttccatt tcagagatgg ttcccctact atcgcaactc   180
tttctcggga ttctaggaga ttttcaagaa aatagagtca aacacgcact ctggattgcc   240
aaaatcaaaa tcctgctcta cgctattttg acagtatttc tcgtcttgtc gcccttttca   300
ttagtttcag tcattatgat tgtcatcatc aacctcatct ctgacacctt gagctacctg   360
tctgcctaca tgatgaacgc cctctacatc agtgtaatta aggacgacct gcatgatgcc   420
atggggttca ggcagtctct gatgagggtt gtccgtattg tcgccaatct ggctggcgca   480
ttccttatca atgttataag tattcaaact atttccctta tcaacactct gacttttgtc   540
attgcctttt tgggcctgta tgttattcga cataccttgt atgaggttga aaaaagaatt   600
gaaatgtcac atacagcact gagttttaag aaatattttc aacatcttaa acagtcgctg   660
gctgtgctcc tgaggttaaa agataccgtc atactactgt ttctgacgac cagtatgatt   720
gccatcttgg atgtgtcccc tcggctgatt gccctccgct tcatccaaca gacactagca   780
caactgagca ttgggcaact cctcgccctg ctctccatca tcatgtcttg tggagctatc   840
cttggcaata tgaccagcag taatctattt aaaaatatcc gtttcacgca cctcttggtt   900
ttctgtgaga tttccctatt gactctaata actagtatcc tttgtcaagc ctatatcgta   960

attttcatga ccagtttcat cagttctacg attatcggca ttctcagccc tcgcctacaa   1020
gcagctgtct ttgcccatat ccccagtgac aagatgggga cggtgggctc tgctctgagc   1080
acagtggaca ttctcgcccc gtccctgctc tccctattag ccctatccat agcatcgggc   1140
gtttcggtgc agttagcatt gatatttttg tatcttattt taattgctct tatcttttgt   1200
caatggttag tcaagttcaa cactcataac                                    1230

<210>   594
<211>   410
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902188 (3.E-74)

<400>   594
Met Lys Leu Phe Trp Thr Asn Asn Ile Tyr Arg Gln Leu Leu Leu Asn 
1               5                   10                  15      

Ser Cys Phe Ser Ser Phe Gly Asp Ser Ile Phe Tyr Leu Ala Ile Ile 
            20                  25                  30          

Asn Tyr Val Ala Gln Tyr Asn Phe Ala Pro Leu Ala Ile Leu Leu Ile 
        35                  40                  45              

Ser Ile Ser Glu Met Val Pro Leu Leu Ser Gln Leu Phe Leu Gly Ile 
    50                  55                  60                  

Leu Gly Asp Phe Gln Glu Asn Arg Val Lys His Ala Leu Trp Ile Ala 
65                  70                  75                  80  

Lys Ile Lys Ile Leu Leu Tyr Ala Ile Leu Thr Val Phe Leu Val Leu 
                85                  90                  95      

Ser Pro Phe Ser Leu Val Ser Val Ile Met Ile Val Ile Ile Asn Leu 
            100                 105                 110         

Ile Ser Asp Thr Leu Ser Tyr Leu Ser Ala Tyr Met Met Asn Ala Leu 
        115                 120                 125             

Tyr Ile Ser Val Ile Lys Asp Asp Leu His Asp Ala Met Gly Phe Arg 
    130                 135                 140                 

Gln Ser Leu Met Arg Val Val Arg Ile Val Ala Asn Leu Ala Gly Ala 
145                 150                 155                 160 

Phe Leu Ile Asn Val Ile Ser Ile Gln Thr Ile Ser Leu Ile Asn Thr 
                165                 170                 175     

Leu Thr Phe Val Ile Ala Phe Leu Gly Leu Tyr Val Ile Arg His Thr 
            180                 185                 190         

Leu Tyr Glu Val Glu Lys Arg Ile Glu Met Ser His Thr Ala Leu Ser 
        195                 200                 205             

Phe Lys Lys Tyr Phe Gln His Leu Lys Gln Ser Leu Ala Val Leu Leu 
    210                 215                 220                 

Arg Leu Lys Asp Thr Val Ile Leu Leu Phe Leu Thr Thr Ser Met Ile 
225                 230                 235                 240 

Ala Ile Leu Asp Val Ser Pro Arg Leu Ile Ala Leu Arg Phe Ile Gln 
                245                 250                 255     

Gln Thr Leu Ala Gln Leu Ser Ile Gly Gln Leu Leu Ala Leu Leu Ser 
            260                 265                 270         

Ile Ile Met Ser Cys Gly Ala Ile Leu Gly Asn Met Thr Ser Ser Asn 
        275                 280                 285             

Leu Phe Lys Asn Ile Arg Phe Thr His Leu Leu Val Phe Cys Glu Ile 
    290                 295                 300                 

Ser Leu Leu Thr Leu Ile Thr Ser Ile Leu Cys Gln Ala Tyr Ile Val 
305                 310                 315                 320 

Ile Phe Met Thr Ser Phe Ile Ser Ser Thr Ile Ile Gly Ile Leu Ser 
                325                 330                 335     

Pro Arg Leu Gln Ala Ala Val Phe Ala His Ile Pro Ser Asp Lys Met 
            340                 345                 350         

Gly Thr Val Gly Ser Ala Leu Ser Thr Val Asp Ile Leu Ala Pro Ser 
        355                 360                 365             

Leu Leu Ser Leu Leu Ala Leu Ser Ile Ala Ser Gly Val Ser Val Gln 
    370                 375                 380                 

Leu Ala Leu Ile Phe Leu Tyr Leu Ile Leu Ile Ala Leu Ile Phe Cys 
385                 390                 395                 400 

Gln Trp Leu Val Lys Phe Asn Thr His Asn 
                405                 410 

<210>   595
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   595
ttgtaccccc cagaactgga ttctaaaata ctctctatca tcaagaaggc agtgacaatt   60
agaacgacac acacatatga atatcaatac tcactgctat ttggtgatgc aggctatcta   120
tggttactcc tacatttatt ttctatcagt aaaaatcaat actatctaca attagcaaac   180
gtcaccgcta aaaaattaat agagaattat gatactctag aggaaataga ctttgcattg   240
ggaaaatctg gtgtcctatt atcattaata aaatactatc aatttaccaa tgacaatact   300
cttaaaattt tcatccacaa tagtataggg gaaatttatc attatttcct acaaagagat   360
acagccaaag aaagcatttt agactatagc tttgctcatg gatattgtgg aattgcatat   420
gctttatttg cctattctaa agtcttagaa ccttctatgt tttataatga tctccataca   480
ttccatactg aattaaaaaa attattagaa aaagttactt ctaatactga aaatttagga   540
aatttacaac tttcttggtg caaaggaatt tccggaataa tcttatatct ttgtatgtac   600
gattgtgacg gaaacaaaga tattattagt aaatatcaag aatttgtttt taaccatcat   660
ctaaaaatga tgacaggata ttgccacgga ataactagct tactacaaac cactgtctac   720
aatcaaaaca aattactgat gaaaaaaatc caacaggtaa ttttagcatg ttctgaacga   780
gatgatcacg gtttactgat gtttcaagga gatagtggta aagcagattt gtttgacttc   840
ggaataggaa gcatggggta tattggtgtc tat                                873

<210>   596
<211>   291
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   596
Met Tyr Pro Pro Glu Leu Asp Ser Lys Ile Leu Ser Ile Ile Lys Lys 
1               5                   10                  15      

Ala Val Thr Ile Arg Thr Thr His Thr Tyr Glu Tyr Gln Tyr Ser Leu 
            20                  25                  30          

Leu Phe Gly Asp Ala Gly Tyr Leu Trp Leu Leu Leu His Leu Phe Ser 
        35                  40                  45              

Ile Ser Lys Asn Gln Tyr Tyr Leu Gln Leu Ala Asn Val Thr Ala Lys 
    50                  55                  60                  

Lys Leu Ile Glu Asn Tyr Asp Thr Leu Glu Glu Ile Asp Phe Ala Leu 
65                  70                  75                  80  

Gly Lys Ser Gly Val Leu Leu Ser Leu Ile Lys Tyr Tyr Gln Phe Thr 
                85                  90                  95      

Asn Asp Asn Thr Leu Lys Ile Phe Ile His Asn Ser Ile Gly Glu Ile 
            100                 105                 110         

Tyr His Tyr Phe Leu Gln Arg Asp Thr Ala Lys Glu Ser Ile Leu Asp 
        115                 120                 125             

Tyr Ser Phe Ala His Gly Tyr Cys Gly Ile Ala Tyr Ala Leu Phe Ala 
    130                 135                 140                 

Tyr Ser Lys Val Leu Glu Pro Ser Met Phe Tyr Asn Asp Leu His Thr 
145                 150                 155                 160 

Phe His Thr Glu Leu Lys Lys Leu Leu Glu Lys Val Thr Ser Asn Thr 
                165                 170                 175     

Glu Asn Leu Gly Asn Leu Gln Leu Ser Trp Cys Lys Gly Ile Ser Gly 
            180                 185                 190         

Ile Ile Leu Tyr Leu Cys Met Tyr Asp Cys Asp Gly Asn Lys Asp Ile 
        195                 200                 205             

Ile Ser Lys Tyr Gln Glu Phe Val Phe Asn His His Leu Lys Met Met 
    210                 215                 220                 

Thr Gly Tyr Cys His Gly Ile Thr Ser Leu Leu Gln Thr Thr Val Tyr 
225                 230                 235                 240 

Asn Gln Asn Lys Leu Leu Met Lys Lys Ile Gln Gln Val Ile Leu Ala 
                245                 250                 255     

Cys Ser Glu Arg Asp Asp His Gly Leu Leu Met Phe Gln Gly Asp Ser 
            260                 265                 270         

Gly Lys Ala Asp Leu Phe Asp Phe Gly Ile Gly Ser Met Gly Tyr Ile 
        275                 280                 285             

Gly Val Tyr 
    290     

<210>   597
<211>   876
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   597
atgacaaaaa aagttggtgt cggtcaggca catagtaaga taattttaat aggggaacat   60
gcggtcgttt acggttatcc tgccatttcc ctgcctcttt tggaggtgga ggtgacctgt   120
aaggtagttc ctgcagagag tccttggcgc ctttatgagg aggatacctt gtccatggcg   180
gtttatgcct cactggagta tttgaatatc acagaagcct gcattcgttg tgagattgac   240
tcggctatcc ctgagaaacg ggggatgggt tcgtcagcgg ctatcagcat agcggccatt   300
cgtgcagtat ttgactacta tcaggctgat ctgcctcatg atgtactaga aatcttggtc   360
aatcgagctg aaatgattgc ccatatgaat cctagtggtt tggatgctaa gacctgtctt   420
agtgaccaac ctattcgctt tatcaagaac gtaggattta cagaacttga gatggattta   480
tccgcctatt tggtgattgc cgatacgggt gtttatggtc atactcgtga agccatccaa   540
gtggttcaaa ataagggcaa ggatgcccta ccgtttttgc atgccttggg agaattaacc   600
cagcaagcag aagttgcgat ttcacaaaaa gatgctgaag gactgggaca aatcctcagt   660
caagcgcatt tacatttaaa agaaattgga gtcagtagcc ctgaggcaga ctttttggtt   720
gaaacgactc ttagccatgg tgctctgggt gccaagatga gcggtggtgg gctaggaggt   780
tgtatcatag ccttggtaac caatttgaca cacgcacaag aactagcaga aagattagaa   840
gagaaaggag ctgttcagac atggatagag agcctg                             876

<210>   598
<211>   292
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   mevalonate kinase (mvaK1)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902382 (e-162)

<400>   598
Met Thr Lys Lys Val Gly Val Gly Gln Ala His Ser Lys Ile Ile Leu 
1               5                   10                  15      

Ile Gly Glu His Ala Val Val Tyr Gly Tyr Pro Ala Ile Ser Leu Pro 
            20                  25                  30          

Leu Leu Glu Val Glu Val Thr Cys Lys Val Val Pro Ala Glu Ser Pro 
        35                  40                  45              

Trp Arg Leu Tyr Glu Glu Asp Thr Leu Ser Met Ala Val Tyr Ala Ser 
    50                  55                  60                  

Leu Glu Tyr Leu Asn Ile Thr Glu Ala Cys Ile Arg Cys Glu Ile Asp 
65                  70                  75                  80  

Ser Ala Ile Pro Glu Lys Arg Gly Met Gly Ser Ser Ala Ala Ile Ser 
                85                  90                  95      

Ile Ala Ala Ile Arg Ala Val Phe Asp Tyr Tyr Gln Ala Asp Leu Pro 
            100                 105                 110         

His Asp Val Leu Glu Ile Leu Val Asn Arg Ala Glu Met Ile Ala His 
        115                 120                 125             

Met Asn Pro Ser Gly Leu Asp Ala Lys Thr Cys Leu Ser Asp Gln Pro 
    130                 135                 140                 

Ile Arg Phe Ile Lys Asn Val Gly Phe Thr Glu Leu Glu Met Asp Leu 
145                 150                 155                 160 

Ser Ala Tyr Leu Val Ile Ala Asp Thr Gly Val Tyr Gly His Thr Arg 
                165                 170                 175     

Glu Ala Ile Gln Val Val Gln Asn Lys Gly Lys Asp Ala Leu Pro Phe 
            180                 185                 190         

Leu His Ala Leu Gly Glu Leu Thr Gln Gln Ala Glu Val Ala Ile Ser 
        195                 200                 205             

Gln Lys Asp Ala Glu Gly Leu Gly Gln Ile Leu Ser Gln Ala His Leu 
    210                 215                 220                 

His Leu Lys Glu Ile Gly Val Ser Ser Pro Glu Ala Asp Phe Leu Val 
225                 230                 235                 240 

Glu Thr Thr Leu Ser His Gly Ala Leu Gly Ala Lys Met Ser Gly Gly 
                245                 250                 255     

Gly Leu Gly Gly Cys Ile Ile Ala Leu Val Thr Asn Leu Thr His Ala 
            260                 265                 270         

Gln Glu Leu Ala Glu Arg Leu Glu Glu Lys Gly Ala Val Gln Thr Trp 
        275                 280                 285             

Ile Glu Ser Leu 
    290         

<210>   599
<211>   951
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   599
atggatagag agcctgtaac agtacgttcc tacgcaaata ttgctattat caaatattgg   60
ggaaagaaaa aagaaaaaga gatggtgcct gctactagca gtatttctct aactttggaa   120
aatatgtata cagagacgac cttgtcgcct ttaccagcca atgtaacagc tgacgaattt   180
tacatcaatg gtcagctaca aaatgaggtc gagcatgcca agatgagtaa gattattgac   240
cgttatcgtc cagctggtga gggctttgtc cgtatcgata ctcaaaacaa tatgcctacg   300
gcagcgggtc tgtcctcaag ttctagtggt ttgtccgccc tggtcaaggc ttgtaatgct   360
tatttcaagc ttggattgga tagaagtcag ttggcacagg aagccaaatt tgcctcaggt   420
tcttcttctc ggagttttta tggaccacta ggagcctggg ataaggatag tggagaaatt   480
taccctgtag agacagactt gaaactagct atgattatgt tggtgctaga ggacaagaaa   540
aaaccaatct ctagccgtga cgggatgaaa ctttgtgtgg aaacctcgac gactttcgac   600
gactgggttc gtcagtctga gaaggactat caggatatgc tgatttatct caaggaaaat   660
gattttgcca agattggaga attaacggag aaaaatgccc tggctatgca tgctacgaca   720
aagactgcta gtccagcctt ttcttatctg acggatgcct cttatgaggc tatggccttt   780
gttcgccagc ttcgtgagaa aggagaggcc tgctacttta ccatggatgc tggtcccaat   840
gttaaggtct tctgtcagga gaaagacttg gagcatttat cagaaatttt cggtcatcgt   900
tatcgcttga ttgtgtcaaa aacaaaggat ttgagtcaag atgattgctg t            951

<210>   600
<211>   317
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   mevalonate diphosphate decarboxylase (mvaD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902383 (0.E+01)

<400>   600
Met Asp Arg Glu Pro Val Thr Val Arg Ser Tyr Ala Asn Ile Ala Ile 
1               5                   10                  15      

Ile Lys Tyr Trp Gly Lys Lys Lys Glu Lys Glu Met Val Pro Ala Thr 
            20                  25                  30          

Ser Ser Ile Ser Leu Thr Leu Glu Asn Met Tyr Thr Glu Thr Thr Leu 
        35                  40                  45              

Ser Pro Leu Pro Ala Asn Val Thr Ala Asp Glu Phe Tyr Ile Asn Gly 
    50                  55                  60                  

Gln Leu Gln Asn Glu Val Glu His Ala Lys Met Ser Lys Ile Ile Asp 
65                  70                  75                  80  

Arg Tyr Arg Pro Ala Gly Glu Gly Phe Val Arg Ile Asp Thr Gln Asn 
                85                  90                  95      

Asn Met Pro Thr Ala Ala Gly Leu Ser Ser Ser Ser Ser Gly Leu Ser 
            100                 105                 110         

Ala Leu Val Lys Ala Cys Asn Ala Tyr Phe Lys Leu Gly Leu Asp Arg 
        115                 120                 125             

Ser Gln Leu Ala Gln Glu Ala Lys Phe Ala Ser Gly Ser Ser Ser Arg 
    130                 135                 140                 

Ser Phe Tyr Gly Pro Leu Gly Ala Trp Asp Lys Asp Ser Gly Glu Ile 
145                 150                 155                 160 

Tyr Pro Val Glu Thr Asp Leu Lys Leu Ala Met Ile Met Leu Val Leu 
                165                 170                 175     

Glu Asp Lys Lys Lys Pro Ile Ser Ser Arg Asp Gly Met Lys Leu Cys 
            180                 185                 190         

Val Glu Thr Ser Thr Thr Phe Asp Asp Trp Val Arg Gln Ser Glu Lys 
        195                 200                 205             

Asp Tyr Gln Asp Met Leu Ile Tyr Leu Lys Glu Asn Asp Phe Ala Lys 
    210                 215                 220                 

Ile Gly Glu Leu Thr Glu Lys Asn Ala Leu Ala Met His Ala Thr Thr 
225                 230                 235                 240 

Lys Thr Ala Ser Pro Ala Phe Ser Tyr Leu Thr Asp Ala Ser Tyr Glu 
                245                 250                 255     

Ala Met Ala Phe Val Arg Gln Leu Arg Glu Lys Gly Glu Ala Cys Tyr 
            260                 265                 270         

Phe Thr Met Asp Ala Gly Pro Asn Val Lys Val Phe Cys Gln Glu Lys 
        275                 280                 285             

Asp Leu Glu His Leu Ser Glu Ile Phe Gly His Arg Tyr Arg Leu Ile 
    290                 295                 300                 

Val Ser Lys Thr Lys Asp Leu Ser Gln Asp Asp Cys Cys 
305                 310                 315         

<210>   601
<211>   1005
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   601

atgattgctg ttaaaacttg cggaaaactc tattgggcag gtgaatatgc tattttagag   60
ccagggcagt tagctttgat aaaggatatt cccatctata tgagggctga gattgctttt   120
tctgacagct accgtatcta ttcagatatg tttgatttcg cagtggactt aaggcctaat   180
cctgactata gcttgattca agaaacgatt gctttgatgg gagacttcct cgctgttcgt   240
ggtcagaatt taagaccttt ttctctagaa atctgtggca aaatggaacg agaagggaaa   300
aagtttggtc taggttctag tggcagcgtc gttgtcttgg ttgtcaaggc tttactggct   360
ctgtatgatg tttctgttga tcaggagctc ttgttcaagc tgactagcgc tgtcttgctt   420
aagcgaggag acaatggttc catgggcgac cttgcctgta ttgtggcaga ggatttggtt   480
ctctaccagt catttgatcg ccagaaggtg gctgcttggt tagaagaaga aaacttggcg   540
acagttctgg agcgtgattg gggcttttca atttcacaag tgaaaccaac tttagaatgt   600
gatttcttag tgggatggac caaggaagtg gctgtatcga gtcacatggt ccagcaaatc   660
aagcaaaata tcaatcaaaa ttttttaact tcctcaaaag aaacggtgac ttctctggta   720
gaagccttgg aacaggggaa atcagaaaag attatcgatc aagtagaagt agccagcaag   780
cttttagaag gcttgagtac agatatttac acgcctttgc ttagacagtt gaaagaagcc   840
agtcaagatt tgcagaccgt tgccaagagt agtggtgctg gtggtggtga ctgtggcatc   900
gccctgagtt ttgatgcgca atcaaccaaa accttaaaaa atcgttgggc cgatctgggg   960
attgagctct tatatcaaga aaggatagga catgacgaca aatcg                   1005

<210>   602
<211>   335
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphomevalonate kinase (mvaK2)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902384 (0.E+01)

<400>   602
Met Ile Ala Val Lys Thr Cys Gly Lys Leu Tyr Trp Ala Gly Glu Tyr 
1               5                   10                  15      

Ala Ile Leu Glu Pro Gly Gln Leu Ala Leu Ile Lys Asp Ile Pro Ile 
            20                  25                  30          

Tyr Met Arg Ala Glu Ile Ala Phe Ser Asp Ser Tyr Arg Ile Tyr Ser 
        35                  40                  45              

Asp Met Phe Asp Phe Ala Val Asp Leu Arg Pro Asn Pro Asp Tyr Ser 
    50                  55                  60                  

Leu Ile Gln Glu Thr Ile Ala Leu Met Gly Asp Phe Leu Ala Val Arg 
65                  70                  75                  80  

Gly Gln Asn Leu Arg Pro Phe Ser Leu Glu Ile Cys Gly Lys Met Glu 
                85                  90                  95      

Arg Glu Gly Lys Lys Phe Gly Leu Gly Ser Ser Gly Ser Val Val Val 
            100                 105                 110         

Leu Val Val Lys Ala Leu Leu Ala Leu Tyr Asp Val Ser Val Asp Gln 
        115                 120                 125             

Glu Leu Leu Phe Lys Leu Thr Ser Ala Val Leu Leu Lys Arg Gly Asp 
    130                 135                 140                 

Asn Gly Ser Met Gly Asp Leu Ala Cys Ile Val Ala Glu Asp Leu Val 
145                 150                 155                 160 

Leu Tyr Gln Ser Phe Asp Arg Gln Lys Val Ala Ala Trp Leu Glu Glu 
                165                 170                 175     

Glu Asn Leu Ala Thr Val Leu Glu Arg Asp Trp Gly Phe Ser Ile Ser 
            180                 185                 190         

Gln Val Lys Pro Thr Leu Glu Cys Asp Phe Leu Val Gly Trp Thr Lys 
        195                 200                 205             

Glu Val Ala Val Ser Ser His Met Val Gln Gln Ile Lys Gln Asn Ile 
    210                 215                 220                 

Asn Gln Asn Phe Leu Thr Ser Ser Lys Glu Thr Val Thr Ser Leu Val 
225                 230                 235                 240 

Glu Ala Leu Glu Gln Gly Lys Ser Glu Lys Ile Ile Asp Gln Val Glu 
                245                 250                 255     

Val Ala Ser Lys Leu Leu Glu Gly Leu Ser Thr Asp Ile Tyr Thr Pro 
            260                 265                 270         

Leu Leu Arg Gln Leu Lys Glu Ala Ser Gln Asp Leu Gln Thr Val Ala 
        275                 280                 285             

Lys Ser Ser Gly Ala Gly Gly Gly Asp Cys Gly Ile Ala Leu Ser Phe 
    290                 295                 300                 

Asp Ala Gln Ser Thr Lys Thr Leu Lys Asn Arg Trp Ala Asp Leu Gly 
305                 310                 315                 320 

Ile Glu Leu Leu Tyr Gln Glu Arg Ile Gly His Asp Asp Lys Ser 
                325                 330                 335 

<210>   603
<211>   1008
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   603
atgacgacaa atcgtaagga cgagcatatc ctctatgccc ttgagcagaa aagttcctat   60
aatagctttg atgaggtgga gctgattcat tcttccttgc ctctttacaa tctggatgaa   120
atcgatcttt cgacagagtt tgctggtcga aagtgggact ttccttttta tatcaatgcc   180
atgactggtg gaagtaataa gggaagagaa atcaatcaaa agctggctca ggtggcggaa   240
tcctgtggta ttttatttgt aacgggttct tatagcgcag ccctcaaaaa tccaacggat   300
gattcttttt ctgtcaagtc tagtcatccc aatctcctcc ttggaaccaa tattggattg   360
gacaagcctg tcgagttagg acttcagact gtagaagaga tgaatcctgt tctattgcaa   420
gtgcatgtca atgtcatgca ggaattactc atgcccgagg gagaaaggaa gtttagaagc   480
tggcaatcgc atctagcaga ttatagcaag caaattcccg ttcctattgt cctcaaggaa   540
gtgggctttg gaatggatgc caagacaatc gaaagagcct atgaattcgg tgttcgtaca   600
gtggacctat cgggtcgtgg tggcaccagc tttgcctata tcgaaaaccg tcgtagtggc   660
cagcgtgatt acctcaatca atggggtcag tctaccatgc aggcccttct caatgcccaa   720
gaatggaaag ataaggtcga actcttggtt agtggagggg ttcggaatcc gctggatatg   780
attaagtgct tggtttttgg tgctaaggct gtgggattgt cacgaaccgt tctggaattg   840
gttgaaacct acacagttga agaagtgatt ggcattgtcc aaggctggaa agcagatcta   900
cgcttgatta tgtgttccct taactgtgcc accatagcag atctacaaaa agtagactat   960
cttctttatg gaaaattaaa agaagcaaag gatcagatga aaaaggcg                1008

<210>   604
<211>   336
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   FMN-dependent dehydrogenase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902385 (0.E+01)

<400>   604
Met Thr Thr Asn Arg Lys Asp Glu His Ile Leu Tyr Ala Leu Glu Gln 
1               5                   10                  15      

Lys Ser Ser Tyr Asn Ser Phe Asp Glu Val Glu Leu Ile His Ser Ser 
            20                  25                  30          

Leu Pro Leu Tyr Asn Leu Asp Glu Ile Asp Leu Ser Thr Glu Phe Ala 
        35                  40                  45              

Gly Arg Lys Trp Asp Phe Pro Phe Tyr Ile Asn Ala Met Thr Gly Gly 
    50                  55                  60                  

Ser Asn Lys Gly Arg Glu Ile Asn Gln Lys Leu Ala Gln Val Ala Glu 
65                  70                  75                  80  

Ser Cys Gly Ile Leu Phe Val Thr Gly Ser Tyr Ser Ala Ala Leu Lys 
                85                  90                  95      

Asn Pro Thr Asp Asp Ser Phe Ser Val Lys Ser Ser His Pro Asn Leu 
            100                 105                 110         

Leu Leu Gly Thr Asn Ile Gly Leu Asp Lys Pro Val Glu Leu Gly Leu 
        115                 120                 125             

Gln Thr Val Glu Glu Met Asn Pro Val Leu Leu Gln Val His Val Asn 
    130                 135                 140                 

Val Met Gln Glu Leu Leu Met Pro Glu Gly Glu Arg Lys Phe Arg Ser 
145                 150                 155                 160 

Trp Gln Ser His Leu Ala Asp Tyr Ser Lys Gln Ile Pro Val Pro Ile 
                165                 170                 175     

Val Leu Lys Glu Val Gly Phe Gly Met Asp Ala Lys Thr Ile Glu Arg 
            180                 185                 190         

Ala Tyr Glu Phe Gly Val Arg Thr Val Asp Leu Ser Gly Arg Gly Gly 
        195                 200                 205             

Thr Ser Phe Ala Tyr Ile Glu Asn Arg Arg Ser Gly Gln Arg Asp Tyr 
    210                 215                 220                 

Leu Asn Gln Trp Gly Gln Ser Thr Met Gln Ala Leu Leu Asn Ala Gln 
225                 230                 235                 240 

Glu Trp Lys Asp Lys Val Glu Leu Leu Val Ser Gly Gly Val Arg Asn 
                245                 250                 255     

Pro Leu Asp Met Ile Lys Cys Leu Val Phe Gly Ala Lys Ala Val Gly 
            260                 265                 270         

Leu Ser Arg Thr Val Leu Glu Leu Val Glu Thr Tyr Thr Val Glu Glu 
        275                 280                 285             

Val Ile Gly Ile Val Gln Gly Trp Lys Ala Asp Leu Arg Leu Ile Met 
    290                 295                 300                 

Cys Ser Leu Asn Cys Ala Thr Ile Ala Asp Leu Gln Lys Val Asp Tyr 
305                 310                 315                 320 

Leu Leu Tyr Gly Lys Leu Lys Glu Ala Lys Asp Gln Met Lys Lys Ala 
                325                 330                 335     


<210>   605
<211>   696
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   605
atgagaaaat ttaaaatctt tttatttatc gaagcctgtc ttctgacagg agctctgatt   60
ttgatggtat cagagcattt ttcgcgtttt ctgctgatac tattcctctt tttgcttttg   120
attcgctact acactggtaa agagggaaat aatcttcttt tagtagcggc aaccattctc   180
ttctttttca tcgttatgct caatcctttt gtgattctag ctatttttgt tgcggttatc   240
tatagcctct ttcttcttta cccgatgatg aaccaggaaa aagagcagac caatttggtt   300
tttgaagagg tcgtgacggt taagaaggag aaaaatcgtt ggtttggaaa tcttcatcat   360
ttttcaagct accagacttg ccaattcgat gatatcaatc tctttcgctt catgggcaag   420
gacactattc atctggagag ggtcatctta accaatcatg acaatgtcat tatcctcaga   480
aagatggtag gaacgaccaa aatcatcgta cctgtagatg tggaagtcag tctcagcgtt   540
aactgtctct atggggattt gatttttttc aaccagccca agcgagccct ccgcaatgaa   600
cactatcatc aagaaacaaa agactatctc aagagtaaca agagtgtcaa gattttcttg   660
accactatga ttggtgatgt ggaggtggtt agagga                             696

<210>   606
<211>   232
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902386 (e-130)

<400>   606
Met Arg Lys Phe Lys Ile Phe Leu Phe Ile Glu Ala Cys Leu Leu Thr 
1               5                   10                  15      

Gly Ala Leu Ile Leu Met Val Ser Glu His Phe Ser Arg Phe Leu Leu 
            20                  25                  30          

Ile Leu Phe Leu Phe Leu Leu Leu Ile Arg Tyr Tyr Thr Gly Lys Glu 
        35                  40                  45              

Gly Asn Asn Leu Leu Leu Val Ala Ala Thr Ile Leu Phe Phe Phe Ile 
    50                  55                  60                  

Val Met Leu Asn Pro Phe Val Ile Leu Ala Ile Phe Val Ala Val Ile 
65                  70                  75                  80  

Tyr Ser Leu Phe Leu Leu Tyr Pro Met Met Asn Gln Glu Lys Glu Gln 
                85                  90                  95      

Thr Asn Leu Val Phe Glu Glu Val Val Thr Val Lys Lys Glu Lys Asn 
            100                 105                 110         

Arg Trp Phe Gly Asn Leu His His Phe Ser Ser Tyr Gln Thr Cys Gln 
        115                 120                 125             

Phe Asp Asp Ile Asn Leu Phe Arg Phe Met Gly Lys Asp Thr Ile His 
    130                 135                 140                 

Leu Glu Arg Val Ile Leu Thr Asn His Asp Asn Val Ile Ile Leu Arg 
145                 150                 155                 160 

Lys Met Val Gly Thr Thr Lys Ile Ile Val Pro Val Asp Val Glu Val 
                165                 170                 175     

Ser Leu Ser Val Asn Cys Leu Tyr Gly Asp Leu Ile Phe Phe Asn Gln 
            180                 185                 190         

Pro Lys Arg Ala Leu Arg Asn Glu His Tyr His Gln Glu Thr Lys Asp 
        195                 200                 205             

Tyr Leu Lys Ser Asn Lys Ser Val Lys Ile Phe Leu Thr Thr Met Ile 
    210                 215                 220                 

Gly Asp Val Glu Val Val Arg Gly 
225                 230         

<210>   607
<211>   993
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   607
atgaaaaaac aagcctatgt cattattgct ctcacctcct tcctatttgt cttttttttc   60
tcccacagct tgctggaaat acttgatttt gactggtcta tctttttgca cgatgtcgaa   120
aaaacagaaa aatttgtctt tttattgttg gttttcagca tgtccatgac ctgtctctta   180
gccctgtttt ggcgagggat cgaagagctt tctctaagaa aaatgcaggc taatctcaag   240
cgtttattag cagggcaaga agtggttcag gttgcagatc cagatttgga tgccagtttc   300
aagtccttat caggtaaact taaccttttg acagaggctc ttcaaaaagc tgaaaatcag   360
agccttgctc aggaagagga aatcatcgag aaggaacgga agcgaattgc tcgggatttg   420
cacgatacag tcagtcagga gttgtttgcg gcccacatga ttttatcggg tatcagtcag   480
caggctttga aattggatag agaaaagatg cagacccagt tgcagagtgt cacagctatt   540
ttagaaacag cccagaagga tttgcgggtt ttgctcttgc atttgcgacc agttgaactg   600
gagcagaaga gcttgataga agggattcaa attcttttaa aagagcttga ggacaagagt   660
gatcttaggg ttagtctcaa gcagaatatg acgaaattgc ctaagaaaat cgaggagcat   720
atcttccgta tcctgcaaga gttgattagc aataccctcc gccatgccca ggcatcttgc   780
ctagatgtct acctctatca gacagatgtt gaattgcaac tgaaggtggt ggacaatggg   840
attggtttcc agttagggag cttagacgac ttgagttatg gactgcgaaa tatcaaggag   900
cgggttgaag atatggctgg aacagttcaa ctcttgacag ctcccaagca agggctggcg   960
gttgatatcc gtattcccct gttagataag gaa                                993

<210>   608
<211>   331
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase, putative
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902387 (0.E+01)

<400>   608
Met Lys Lys Gln Ala Tyr Val Ile Ile Ala Leu Thr Ser Phe Leu Phe 
1               5                   10                  15      

Val Phe Phe Phe Ser His Ser Leu Leu Glu Ile Leu Asp Phe Asp Trp 
            20                  25                  30          

Ser Ile Phe Leu His Asp Val Glu Lys Thr Glu Lys Phe Val Phe Leu 
        35                  40                  45              

Leu Leu Val Phe Ser Met Ser Met Thr Cys Leu Leu Ala Leu Phe Trp 
    50                  55                  60                  

Arg Gly Ile Glu Glu Leu Ser Leu Arg Lys Met Gln Ala Asn Leu Lys 
65                  70                  75                  80  

Arg Leu Leu Ala Gly Gln Glu Val Val Gln Val Ala Asp Pro Asp Leu 
                85                  90                  95      

Asp Ala Ser Phe Lys Ser Leu Ser Gly Lys Leu Asn Leu Leu Thr Glu 
            100                 105                 110         

Ala Leu Gln Lys Ala Glu Asn Gln Ser Leu Ala Gln Glu Glu Glu Ile 
        115                 120                 125             

Ile Glu Lys Glu Arg Lys Arg Ile Ala Arg Asp Leu His Asp Thr Val 
    130                 135                 140                 

Ser Gln Glu Leu Phe Ala Ala His Met Ile Leu Ser Gly Ile Ser Gln 
145                 150                 155                 160 

Gln Ala Leu Lys Leu Asp Arg Glu Lys Met Gln Thr Gln Leu Gln Ser 
                165                 170                 175     

Val Thr Ala Ile Leu Glu Thr Ala Gln Lys Asp Leu Arg Val Leu Leu 
            180                 185                 190         

Leu His Leu Arg Pro Val Glu Leu Glu Gln Lys Ser Leu Ile Glu Gly 
        195                 200                 205             

Ile Gln Ile Leu Leu Lys Glu Leu Glu Asp Lys Ser Asp Leu Arg Val 
    210                 215                 220                 

Ser Leu Lys Gln Asn Met Thr Lys Leu Pro Lys Lys Ile Glu Glu His 
225                 230                 235                 240 

Ile Phe Arg Ile Leu Gln Glu Leu Ile Ser Asn Thr Leu Arg His Ala 
                245                 250                 255     

Gln Ala Ser Cys Leu Asp Val Tyr Leu Tyr Gln Thr Asp Val Glu Leu 
            260                 265                 270         

Gln Leu Lys Val Val Asp Asn Gly Ile Gly Phe Gln Leu Gly Ser Leu 
        275                 280                 285             

Asp Asp Leu Ser Tyr Gly Leu Arg Asn Ile Lys Glu Arg Val Glu Asp 
    290                 295                 300                 

Met Ala Gly Thr Val Gln Leu Leu Thr Ala Pro Lys Gln Gly Leu Ala 
305                 310                 315                 320 

Val Asp Ile Arg Ile Pro Leu Leu Asp Lys Glu 
                325                 330     

<210>   609
<211>   630
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   609
atgaaaattt tactagtaga tgaccatgaa atggtccgat tgggcttgaa aagctacttt   60
gacctccaag acgatgtaga agttgtgggt gaggcgtcca acgggtctca agggattgac   120
ttggccttgg aactgcgtcc agatgtcatt gtcatggata ttgtcatgcc tgagatgaat   180
gggattgacg cgaccttagc aatccttaaa gaatggcctg aagccaagat tttgattgtg   240
acctcttatt tggacaatga aaaaatcatg ccagtcttag atgctggtgc caaaggctat   300
atgctcaaga cttctagtgc agatgaattg cttcatgccg tcagtaaggt agctgctggc   360
gagctggcca ttgagcaaga ggttagcaag aaggttgaat accaccgcaa tcatatggaa   420
cttcatgaag aattgactgc gcgtgagcga gatgttctcc aactcatcgc caagggctac   480
gaaaatcagc gcatcgcaga tgacctcttt atctctctca agacggtcaa gacccacgtg   540
tccaatattc ttgccaaact tgaagtcagc gatcgtaccc aggcggctgt ctatgccttt   600
cagcaccatt tggtggggca agaggagttt                                    630

<210>   610
<211>   210
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902388 (e-115)

<400>   610
Met Lys Ile Leu Leu Val Asp Asp His Glu Met Val Arg Leu Gly Leu 
1               5                   10                  15      

Lys Ser Tyr Phe Asp Leu Gln Asp Asp Val Glu Val Val Gly Glu Ala 
            20                  25                  30          

Ser Asn Gly Ser Gln Gly Ile Asp Leu Ala Leu Glu Leu Arg Pro Asp 
        35                  40                  45              

Val Ile Val Met Asp Ile Val Met Pro Glu Met Asn Gly Ile Asp Ala 
    50                  55                  60                  

Thr Leu Ala Ile Leu Lys Glu Trp Pro Glu Ala Lys Ile Leu Ile Val 

65                  70                  75                  80  

Thr Ser Tyr Leu Asp Asn Glu Lys Ile Met Pro Val Leu Asp Ala Gly 
                85                  90                  95      

Ala Lys Gly Tyr Met Leu Lys Thr Ser Ser Ala Asp Glu Leu Leu His 
            100                 105                 110         

Ala Val Ser Lys Val Ala Ala Gly Glu Leu Ala Ile Glu Gln Glu Val 
        115                 120                 125             

Ser Lys Lys Val Glu Tyr His Arg Asn His Met Glu Leu His Glu Glu 
    130                 135                 140                 

Leu Thr Ala Arg Glu Arg Asp Val Leu Gln Leu Ile Ala Lys Gly Tyr 
145                 150                 155                 160 

Glu Asn Gln Arg Ile Ala Asp Asp Leu Phe Ile Ser Leu Lys Thr Val 
                165                 170                 175     

Lys Thr His Val Ser Asn Ile Leu Ala Lys Leu Glu Val Ser Asp Arg 
            180                 185                 190         

Thr Gln Ala Ala Val Tyr Ala Phe Gln His His Leu Val Gly Gln Glu 
        195                 200                 205             

Glu Phe 
    210 

<210>   611
<211>   372
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   611
ttgcggtgcc tgaaagaaat aaactctata aaatattttc cagaagcgaa aaaaacaaag   60
attatcgatt gggattttgc agacacttgc tgggaaaagg atcctagaaa ataccaatat   120
gtggctgcta actatttgaa agcaatgcag tcttatctaa aggaaaccga tttgcctaag   180
ctagagcagt tagtcgtgac aaaatccttg tgggacacgg tagatatcct agatcgagta   240
gtagggagtt tggtgtatga acaccctgaa ctagaagaaa taatcttaat actcttcgaa   300
aatctcttca aaccacgtca gctctatctg caacctcaaa acagtgtttt gagcaacctg   360
cggctagctt cc                                                       372

<210>   612
<211>   124
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein

<400>   612
Met Arg Cys Leu Lys Glu Ile Asn Ser Ile Lys Tyr Phe Pro Glu Ala 
1               5                   10                  15      

Lys Lys Thr Lys Ile Ile Asp Trp Asp Phe Ala Asp Thr Cys Trp Glu 
            20                  25                  30          

Lys Asp Pro Arg Lys Tyr Gln Tyr Val Ala Ala Asn Tyr Leu Lys Ala 
        35                  40                  45              

Met Gln Ser Tyr Leu Lys Glu Thr Asp Leu Pro Lys Leu Glu Gln Leu 
    50                  55                  60                  

Val Val Thr Lys Ser Leu Trp Asp Thr Val Asp Ile Leu Asp Arg Val 
65                  70                  75                  80  

Val Gly Ser Leu Val Tyr Glu His Pro Glu Leu Glu Glu Ile Ile Leu 
                85                  90                  95      

Ile Leu Phe Glu Asn Leu Phe Lys Pro Arg Gln Leu Tyr Leu Gln Pro 
            100                 105                 110         

Gln Asn Ser Val Leu Ser Asn Leu Arg Leu Ala Ser 
        115                 120                 

<210>   613
<211>   270
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   613
ttgagtataa aatggagcct atcagataat atctggctga gacgtgtcgc tattgaccac   60
cagttgttaa gaaaagagaa gaccaatact caattaatgg aaaagattct ccttcataac   120
ttgaaccaaa cagaattttt tatcaataaa gccattggct ggactctgcg agactactcc   180
aaaacgaatc ccacttgggt aacatgcttt attgagaaaa acaaggaaag aatggctgaa   240
cttagtatca aagaagcaag caagtacctc                                    270

<210>   614
<211>   90
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA alkylation repair enzyme, putative, POINT MUTATION

<400>   614
Met Ser Ile Lys Trp Ser Leu Ser Asp Asn Ile Trp Leu Arg Arg Val 
1               5                   10                  15      

Ala Ile Asp His Gln Leu Leu Arg Lys Glu Lys Thr Asn Thr Gln Leu 
            20                  25                  30          

Met Glu Lys Ile Leu Leu His Asn Leu Asn Gln Thr Glu Phe Phe Ile 
        35                  40                  45              

Asn Lys Ala Ile Gly Trp Thr Leu Arg Asp Tyr Ser Lys Thr Asn Pro 
    50                  55                  60                  

Thr Trp Val Thr Cys Phe Ile Glu Lys Asn Lys Glu Arg Met Ala Glu 
65                  70                  75                  80  

Leu Ser Ile Lys Glu Ala Ser Lys Tyr Leu 
                85                  90  

<210>   615
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   615
atgaagaaaa ctgtttataa aaaattgggt atttcaatta ttgcgagtac tttattggct   60
agccagttat cgacagtatc tgctttgagt gttatttcta gtacaggtga agaatatgag   120
gtaagtgaga cactagaaaa aggtccagag tctaatgatt cttcattatc tgagatttca   180
ccaacgtatg gttcatacta ccaaaagcaa tcagaagtat tatcggtaat gatgatt      237

<210>   616
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902392 (5.E-30)

<400>   616
Met Lys Lys Thr Val Tyr Lys Lys Leu Gly Ile Ser Ile Ile Ala Ser 
1               5                   10                  15      

Thr Leu Leu Ala Ser Gln Leu Ser Thr Val Ser Ala Leu Ser Val Ile 
            20                  25                  30          

Ser Ser Thr Gly Glu Glu Tyr Glu Val Ser Glu Thr Leu Glu Lys Gly 
        35                  40                  45              

Pro Glu Ser Asn Asp Ser Ser Leu Ser Glu Ile Ser Pro Thr Tyr Gly 
    50                  55                  60                  

Ser Tyr Tyr Gln Lys Gln Ser Glu Val Leu Ser Val Met Met Ile 
65                  70                  75                  

<210>   617
<211>   903
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   617
ttgattaaaa ttgataatac tttacagtat ccgtattcga cttcagctat ggttttatct   60
aagtattatg gagtagccga tggaatgaat gtagaaggga ggggaagtgc gaattttatt   120
aaagataatg tgttaattac agcggctcac aactactaca gacatgacta tgggaaagaa   180
gcggatgata tttatgttct tccggctgtt agtccaagtc aagaaccatt tggaaagatc   240
aaagtaaagg aagttcgtta tttgaaggaa tttagaaatt taaattctaa ggatgcaagg   300
gaatatgact tggctttatt aattctagaa gagcccattg gtgcaaaatt agggactttg   360
ggtcttccta ctagtcaaaa aaatttgaca ggaataactg tgactatcac aggctatcca   420
tcatataatt ttaaaattca tcaaatgtat acagataaaa aacaagtttt aagtgatgat   480
ggcatgttct tggattacca agttgatact ttagaggggt ctagtggatc tacagtttat   540
gatgctagtc accgtgtagt aggagtgcat actttaggag atggagctaa tcaaattaac   600
agtgcagtta aattaaatga acgaaatttg ccatttattt attcggttct taaaggttac   660
tctcttgaag gatggaagaa aataaatggt agttggtacc attatagaca acatgataaa   720
caaacgggtt ggcaggagat aaatgatact tggtattatt tagacagttc cggtaagatg   780
cttacagatt ggcaaaaagt aaatggaaaa tggtattatc tcaattcaaa tggagcaatg   840
gttacaggta gccaaactat cgatggtaaa gtttataact tcgcttcatc tggtgagtgg   900
att                                                                 903

<210>   618
<211>   301
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline binding protein G (cbpG)
<223>   Cellular location: cytoplasm
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15902393 (e-111)

<400>   618
Met Ile Lys Ile Asp Asn Thr Leu Gln Tyr Pro Tyr Ser Thr Ser Ala 
1               5                   10                  15      

Met Val Leu Ser Lys Tyr Tyr Gly Val Ala Asp Gly Met Asn Val Glu 
            20                  25                  30          

Gly Arg Gly Ser Ala Asn Phe Ile Lys Asp Asn Val Leu Ile Thr Ala 
        35                  40                  45              

Ala His Asn Tyr Tyr Arg His Asp Tyr Gly Lys Glu Ala Asp Asp Ile 
    50                  55                  60                  

Tyr Val Leu Pro Ala Val Ser Pro Ser Gln Glu Pro Phe Gly Lys Ile 
65                  70                  75                  80  

Lys Val Lys Glu Val Arg Tyr Leu Lys Glu Phe Arg Asn Leu Asn Ser 
                85                  90                  95      

Lys Asp Ala Arg Glu Tyr Asp Leu Ala Leu Leu Ile Leu Glu Glu Pro 
            100                 105                 110         

Ile Gly Ala Lys Leu Gly Thr Leu Gly Leu Pro Thr Ser Gln Lys Asn 
        115                 120                 125             

Leu Thr Gly Ile Thr Val Thr Ile Thr Gly Tyr Pro Ser Tyr Asn Phe 
    130                 135                 140                 

Lys Ile His Gln Met Tyr Thr Asp Lys Lys Gln Val Leu Ser Asp Asp 
145                 150                 155                 160 

Gly Met Phe Leu Asp Tyr Gln Val Asp Thr Leu Glu Gly Ser Ser Gly 
                165                 170                 175     

Ser Thr Val Tyr Asp Ala Ser His Arg Val Val Gly Val His Thr Leu 
            180                 185                 190         

Gly Asp Gly Ala Asn Gln Ile Asn Ser Ala Val Lys Leu Asn Glu Arg 
        195                 200                 205             

Asn Leu Pro Phe Ile Tyr Ser Val Leu Lys Gly Tyr Ser Leu Glu Gly 
    210                 215                 220                 

Trp Lys Lys Ile Asn Gly Ser Trp Tyr His Tyr Arg Gln His Asp Lys 
225                 230                 235                 240 

Gln Thr Gly Trp Gln Glu Ile Asn Asp Thr Trp Tyr Tyr Leu Asp Ser 
                245                 250                 255     

Ser Gly Lys Met Leu Thr Asp Trp Gln Lys Val Asn Gly Lys Trp Tyr 
            260                 265                 270         

Tyr Leu Asn Ser Asn Gly Ala Met Val Thr Gly Ser Gln Thr Ile Asp 
        275                 280                 285             

Gly Lys Val Tyr Asn Phe Ala Ser Ser Gly Glu Trp Ile 
    290                 295                 300     

<210>   619
<211>   1020
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   619
atgaagcttt tgaaaaaaat gatgcaaatc gcactagcca catttttctt cggtttgtta   60
gcgacaaata cagtatttgc agatgattct gaaggatggc agtttgtcca agaaaatggt   120
agaacctact acaaaaaggg ggatctaaaa gaaacctact ggagagtgat agatgggaag   180
tactattatt ttgatccttt atccggagag atggttgtcg gctggcaata tatacctgct   240
ccacacaagg gggttacgat tggtccttct ccaagaatag agattgctct tagaccagat   300
tggttttatt ttggtcaaga tggtgtatta caagaatttg ttggcaagca agttttagaa   360
gcaaaaactg ctacgaatac caacaaacat catggggaag aatatgatag ccaagcagag   420
aaacgagtct attattttga agatcagcgt agttatcata ctttaaaaac tggttggatt   480
tatgaagagg gtcattggta ttatttacag aaggatggtg gctttgattc gcgcatcaac   540
agattgacgg ttggagagct agcacgtggt tgggttaagg attaccctct tacgtatgat   600
gaagagaagc taaaagcagc tccatggtac tatctaaatc cagcaactgg cattatgcaa   660
acaggttggc aatatctagg taatagatgg tactacctcc attcgtcagg agctatggca   720
actggctggt ataaggaagg ctcaacttgg tactatctag atgctgaaaa tggtgatatg   780
agaactggct ggcaaaacct tgggaacaaa tggtactatc tccgttcatc aggagctatg   840
gcaactggtt ggtatcagga aagttcgact tggtactatc taaatgcaag taatggagat   900
atgaaaacag gctggttcca agtcaatggt aactggtact atgcctatga ttcaggtgct   960
ttagctgtta ataccacagt aggtggttac tacttaaact ataatggtga atgggttaag   1020

<210>   620
<211>   340
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline binding protein F (cbpF)
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15902395 (e-164)

<400>   620
Met Lys Leu Leu Lys Lys Met Met Gln Ile Ala Leu Ala Thr Phe Phe 
1               5                   10                  15      

Phe Gly Leu Leu Ala Thr Asn Thr Val Phe Ala Asp Asp Ser Glu Gly 
            20                  25                  30          

Trp Gln Phe Val Gln Glu Asn Gly Arg Thr Tyr Tyr Lys Lys Gly Asp 
        35                  40                  45              

Leu Lys Glu Thr Tyr Trp Arg Val Ile Asp Gly Lys Tyr Tyr Tyr Phe 
    50                  55                  60                  

Asp Pro Leu Ser Gly Glu Met Val Val Gly Trp Gln Tyr Ile Pro Ala 
65                  70                  75                  80  

Pro His Lys Gly Val Thr Ile Gly Pro Ser Pro Arg Ile Glu Ile Ala 
                85                  90                  95      

Leu Arg Pro Asp Trp Phe Tyr Phe Gly Gln Asp Gly Val Leu Gln Glu 
            100                 105                 110         

Phe Val Gly Lys Gln Val Leu Glu Ala Lys Thr Ala Thr Asn Thr Asn 
        115                 120                 125             

Lys His His Gly Glu Glu Tyr Asp Ser Gln Ala Glu Lys Arg Val Tyr 
    130                 135                 140                 

Tyr Phe Glu Asp Gln Arg Ser Tyr His Thr Leu Lys Thr Gly Trp Ile 
145                 150                 155                 160 

Tyr Glu Glu Gly His Trp Tyr Tyr Leu Gln Lys Asp Gly Gly Phe Asp 
                165                 170                 175     

Ser Arg Ile Asn Arg Leu Thr Val Gly Glu Leu Ala Arg Gly Trp Val 
            180                 185                 190         

Lys Asp Tyr Pro Leu Thr Tyr Asp Glu Glu Lys Leu Lys Ala Ala Pro 
        195                 200                 205             

Trp Tyr Tyr Leu Asn Pro Ala Thr Gly Ile Met Gln Thr Gly Trp Gln 
    210                 215                 220                 

Tyr Leu Gly Asn Arg Trp Tyr Tyr Leu His Ser Ser Gly Ala Met Ala 
225                 230                 235                 240 

Thr Gly Trp Tyr Lys Glu Gly Ser Thr Trp Tyr Tyr Leu Asp Ala Glu 
                245                 250                 255     

Asn Gly Asp Met Arg Thr Gly Trp Gln Asn Leu Gly Asn Lys Trp Tyr 
            260                 265                 270         

Tyr Leu Arg Ser Ser Gly Ala Met Ala Thr Gly Trp Tyr Gln Glu Ser 
        275                 280                 285             

Ser Thr Trp Tyr Tyr Leu Asn Ala Ser Asn Gly Asp Met Lys Thr Gly 
    290                 295                 300                 

Trp Phe Gln Val Asn Gly Asn Trp Tyr Tyr Ala Tyr Asp Ser Gly Ala 
305                 310                 315                 320 

Leu Ala Val Asn Thr Thr Val Gly Gly Tyr Tyr Leu Asn Tyr Asn Gly 
                325                 330                 335     

Glu Trp Val Lys 
            340 

<210>   621
<211>   486
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   621
atggaaaagt gctacacaga tgtgacagaa tttgccattc cagcaagtac tcaaaagctt   60
tacttatcac cagttttaga tggctttaat agcgaaatta tcgcctataa tctttcaact   120
tcacccaact tagaacaagt acaaacaatg ttggaacagg cattcacaga gaagcactac   180
gagaatacga ttctccatag tgaccaaggc tggcaatacc aacacgattc ttatcatcgg   240
ttcctagaga gtaagggaat tcaagcatcc atgtcacgta agggaaacag cccagacaat   300
agtatgatgg agtccttctt tgggattctg aaatcggaaa tgttttacgg ttatgagaag   360
tcgtttcagt cgcttaagca attggaacaa gccattatag actatattga ttactacaac   420
aataaacgaa ttaaggtaaa actaaaagga cttagccctg tgcaatacag aactaaatcc   480
ttcgga                                                              486

<210>   622
<211>   162
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   probable transposase (insertionsequen)

<400>   622
Met Glu Lys Cys Tyr Thr Asp Val Thr Glu Phe Ala Ile Pro Ala Ser 
1               5                   10                  15      

Thr Gln Lys Leu Tyr Leu Ser Pro Val Leu Asp Gly Phe Asn Ser Glu 
            20                  25                  30          

Ile Ile Ala Tyr Asn Leu Ser Thr Ser Pro Asn Leu Glu Gln Val Gln 
        35                  40                  45              

Thr Met Leu Glu Gln Ala Phe Thr Glu Lys His Tyr Glu Asn Thr Ile 
    50                  55                  60                  

Leu His Ser Asp Gln Gly Trp Gln Tyr Gln His Asp Ser Tyr His Arg 
65                  70                  75                  80  

Phe Leu Glu Ser Lys Gly Ile Gln Ala Ser Met Ser Arg Lys Gly Asn 
                85                  90                  95      

Ser Pro Asp Asn Ser Met Met Glu Ser Phe Phe Gly Ile Leu Lys Ser 
            100                 105                 110         

Glu Met Phe Tyr Gly Tyr Glu Lys Ser Phe Gln Ser Leu Lys Gln Leu 
        115                 120                 125             

Glu Gln Ala Ile Ile Asp Tyr Ile Asp Tyr Tyr Asn Asn Lys Arg Ile 
    130                 135                 140                 

Lys Val Lys Leu Lys Gly Leu Ser Pro Val Gln Tyr Arg Thr Lys Ser 
145                 150                 155                 160 

Phe Gly 
        

<210>   623
<211>   829
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   623
atgactgaat tttcgttagc tcttcttcta aaagtcatta aactagctcg ttcgacctac   60
tactatcact tgaaacagct agataaacca gataaggact aagagcttaa agctgaaatt   120
caatccattt ttatcgaaca caagggaaat tatacttatc gccgggttca tttagaacta   180
agaaatcgtg gttatctggt aaatcataaa agaattcaag gcttgatgaa agtactcaat   240
ttacaagcta aaacgcgaca gaaacgaaaa tattcttctc ataaaagacg ttggcaagaa   300
ggcagagaat ctcattcaag gccaatttga aggctctaaa acaatggaaa agtgctacac   360
agatgtgaca gaatttgcca ttccagcaag tactcaaaag ctttacttat caccagtttt   420
agatggcttt aatagcgaaa ttatcgccta taatctttca acttcaccca acttagaaca   480
agtacaaaca atgttggaac aggcattcac agagaagcac tacgagaata cgattctcca   540
tagtgaccaa ggctggcaat accaacacga ttcttatcat cggttcctag agagtaaggg   600
aattcaagca tccatgtcac gtaagggaaa cagcccagac aatagtatga tggagtcctt   660
ctttgggatt ctgaaatcgg aaatgtttta cggttatgag aagtcgtttc agtcgcttaa   720
gcaattggaa caagccatta tagactatat tgattactac aacaataaac gaattaaggt   780
aaaactaaaa ggacttagcc ctgtgcaata cagaactaaa tccttcgga               829

<210>   624
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, transposase

<400>   624
Met Thr Glu Phe Ser Leu Ala Leu Leu Leu Lys Val Ile Lys Leu Ala 
1               5                   10                  15      

Arg Ser Thr Tyr Tyr Tyr His Leu Lys Gln Leu Asp Lys Pro Asp Lys 
            20                  25                  30          

Asp 
    

<210>   625
<211>   507
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   625
atgaaactaa cttatgatga taaagttcag atctatgaac ttagaaaaca aggatatagc   60
ttagagaagc tttcaaataa atttgggata agcaattcta atattaggta catgattaaa   120
ttgattgatc gttacggaat agagttcgtc aaaaaaggaa aaaatcgtta ctattctcct   180
gatttaaaac aagaaatgag taataaagtc tgacatgaag gctggactaa agatagagtt   240
tctcttgaat acggtctccc aagtcgtacg atacttctta actggctagc acaatacagg   300
aaaaacgggt atactattgt tgagaaaaca agagggagag tacctaaaat gggacgtaag   360
ccaaaaacga gacctgaaga gaggacagaa ttagaacgtc ttcaagcaga aaatgagtac   420
ctgagagcgg agaatgccat cctaaaaaag ttaagagaac tccgattgaa ggaggagaaa   480
gaagaaagac agaaattgtt caagaat                                       507


<210>   626
<400>   626
000

<210>   627
<211>   1767
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   627
atggaagaaa aagtatcatt gaaagtcagg gttcaaaaac tagggacatc gctttcaaat   60
atggttatgc ccaatattgg agcatttatt gcttggggag tattgactgc cctctttatc   120
gctgatggct atctgccaaa tgaacagtta gctactgttg ttggtcctat gttaacgtat   180
ttattgccaa tcctgattgg ttacacaggt ggatatatga tccatggcca acgtggtgcc   240
gttgtaggag ctattgctac tgttggtgca atcacaggtt ctagtgttcc tatgtttatc   300
ggagctatgg taatgggccc actgggagga tggactatca agaaatttga tgagaagttc   360
caggaaaaaa ttcgtcccgg atttgaaatg ttagttaata acttctcagc tggtctcgtt   420
ggttttgcat tattgctttt ggctttctac gcaatcggtc cagtcgtatc gactcttact   480
ggagctgttg ggaatggtgt tgaggctatt gtcaatgctc gcctccttcc tatggctaat   540
attatcatcg aaccggctaa agtccttttc ctcaataatg ccctcaatca tggcattttt   600
actcctctgg gagtagaaca ggtagctcaa gctggtaagt caattctctt cctattggaa   660
gctaatcctg gaccaggtct gggaattcta ttagcttatg ctgtattcgg taaaggttct   720
gctaaatctt cttcttgggg ggcaatggtt attcatttct tcggagggat tcatgaaatt   780
tactttcctt atgttatgat gaagcctact ctatttttag ctgctatggc aggaggtatc   840
tctggaactt ttacttttca actcttagac gctggtctta aatctccagc ttcaccaggt   900
tctattattg cgattatagc tacggcgcca aaaggtgttt ggccccatct aaatgttctt   960
ttaggtgttt tagtggcagc agttgtttct ttccttgtag cagcccttat tcttcatgca   1020
gacaagtcaa ctgaggattc gctcgaagct gctcaggcgg ctacccaagc agctaaggct   1080
cagtctaaag gtcagttagt atcaacttct gttgatgcag ttgtttcgac agactcagtg   1140
gaaaaaatca ttttcgcctg cgatgctggt atgggaagct ctgctatggg agctagtatt   1200
cttcgagata aggttaaaaa agcaggtcta gagattccag tatctaatca ggcaatctca   1260
aatttgcttg atacaccaaa aacattaatt gttactcagg aagaactgac accaagagct   1320
aaagacaaga gtccaagtgc tattcatgtt tctgttgata atttcttagc gtcctctcgt   1380
tatgatgaaa ttgtagcttc attaacagga gcttctccaa tagcagaaat tgaaggagat   1440
ataccaactt cagcaccagt agatagtcag gaaagtgacc ttaaccatat tgatgctgta   1500
gtagttgctt atggtaaagc acagggaact gcaactatgg gctgtgaaac gattcgggct   1560
atttttagaa acaagaatat tcgtattcca gtttctactg ccaaaatttc agaattaggt   1620
gaatttaatt ctaaaaacat aatgattgta acaactattt ctttacaggc agaagtgcag   1680
caagcagcac cgaattctca atttcttatt gtggatagtt tagtaacaac accagaatat   1740
gacaaaatgg ctgctagaat gtacaaa                                       1767

<210>   628
<211>   589
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, mannitol-specific IIBC components
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902400 (0.E+01)

<400>   628
Met Glu Glu Lys Val Ser Leu Lys Val Arg Val Gln Lys Leu Gly Thr 
1               5                   10                  15      

Ser Leu Ser Asn Met Val Met Pro Asn Ile Gly Ala Phe Ile Ala Trp 
            20                  25                  30          

Gly Val Leu Thr Ala Leu Phe Ile Ala Asp Gly Tyr Leu Pro Asn Glu 
        35                  40                  45              

Gln Leu Ala Thr Val Val Gly Pro Met Leu Thr Tyr Leu Leu Pro Ile 
    50                  55                  60                  

Leu Ile Gly Tyr Thr Gly Gly Tyr Met Ile His Gly Gln Arg Gly Ala 
65                  70                  75                  80  

Val Val Gly Ala Ile Ala Thr Val Gly Ala Ile Thr Gly Ser Ser Val 
                85                  90                  95      

Pro Met Phe Ile Gly Ala Met Val Met Gly Pro Leu Gly Gly Trp Thr 
            100                 105                 110         

Ile Lys Lys Phe Asp Glu Lys Phe Gln Glu Lys Ile Arg Pro Gly Phe 
        115                 120                 125             

Glu Met Leu Val Asn Asn Phe Ser Ala Gly Leu Val Gly Phe Ala Leu 
    130                 135                 140                 

Leu Leu Leu Ala Phe Tyr Ala Ile Gly Pro Val Val Ser Thr Leu Thr 
145                 150                 155                 160 

Gly Ala Val Gly Asn Gly Val Glu Ala Ile Val Asn Ala Arg Leu Leu 
                165                 170                 175     

Pro Met Ala Asn Ile Ile Ile Glu Pro Ala Lys Val Leu Phe Leu Asn 
            180                 185                 190         

Asn Ala Leu Asn His Gly Ile Phe Thr Pro Leu Gly Val Glu Gln Val 
        195                 200                 205             

Ala Gln Ala Gly Lys Ser Ile Leu Phe Leu Leu Glu Ala Asn Pro Gly 
    210                 215                 220                 

Pro Gly Leu Gly Ile Leu Leu Ala Tyr Ala Val Phe Gly Lys Gly Ser 
225                 230                 235                 240 

Ala Lys Ser Ser Ser Trp Gly Ala Met Val Ile His Phe Phe Gly Gly 
                245                 250                 255     

Ile His Glu Ile Tyr Phe Pro Tyr Val Met Met Lys Pro Thr Leu Phe 
            260                 265                 270         

Leu Ala Ala Met Ala Gly Gly Ile Ser Gly Thr Phe Thr Phe Gln Leu 
        275                 280                 285             

Leu Asp Ala Gly Leu Lys Ser Pro Ala Ser Pro Gly Ser Ile Ile Ala 
    290                 295                 300                 

Ile Ile Ala Thr Ala Pro Lys Gly Val Trp Pro His Leu Asn Val Leu 
305                 310                 315                 320 

Leu Gly Val Leu Val Ala Ala Val Val Ser Phe Leu Val Ala Ala Leu 
                325                 330                 335     

Ile Leu His Ala Asp Lys Ser Thr Glu Asp Ser Leu Glu Ala Ala Gln 
            340                 345                 350         

Ala Ala Thr Gln Ala Ala Lys Ala Gln Ser Lys Gly Gln Leu Val Ser 
        355                 360                 365             

Thr Ser Val Asp Ala Val Val Ser Thr Asp Ser Val Glu Lys Ile Ile 
    370                 375                 380                 

Phe Ala Cys Asp Ala Gly Met Gly Ser Ser Ala Met Gly Ala Ser Ile 
385                 390                 395                 400 

Leu Arg Asp Lys Val Lys Lys Ala Gly Leu Glu Ile Pro Val Ser Asn 
                405                 410                 415     

Gln Ala Ile Ser Asn Leu Leu Asp Thr Pro Lys Thr Leu Ile Val Thr 
            420                 425                 430         

Gln Glu Glu Leu Thr Pro Arg Ala Lys Asp Lys Ser Pro Ser Ala Ile 
        435                 440                 445             

His Val Ser Val Asp Asn Phe Leu Ala Ser Ser Arg Tyr Asp Glu Ile 
    450                 455                 460                 

Val Ala Ser Leu Thr Gly Ala Ser Pro Ile Ala Glu Ile Glu Gly Asp 
465                 470                 475                 480 

Ile Pro Thr Ser Ala Pro Val Asp Ser Gln Glu Ser Asp Leu Asn His 
                485                 490                 495     

Ile Asp Ala Val Val Val Ala Tyr Gly Lys Ala Gln Gly Thr Ala Thr 
            500                 505                 510         

Met Gly Cys Glu Thr Ile Arg Ala Ile Phe Arg Asn Lys Asn Ile Arg 
        515                 520                 525             

Ile Pro Val Ser Thr Ala Lys Ile Ser Glu Leu Gly Glu Phe Asn Ser 
    530                 535                 540                 

Lys Asn Ile Met Ile Val Thr Thr Ile Ser Leu Gln Ala Glu Val Gln 
545                 550                 555                 560 

Gln Ala Ala Pro Asn Ser Gln Phe Leu Ile Val Asp Ser Leu Val Thr 
                565                 570                 575     

Thr Pro Glu Tyr Asp Lys Met Ala Ala Arg Met Tyr Lys 
            580                 585                 

<210>   629
<211>   1953
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   629
atgctattaa ccaaacgaga agaacaatta ttgaaggctt tcctacatgt agggaagctt   60
tcaatgcaag atatgactga aatcttacag gtttcatcta gaacaattta tcgaacttta   120
tcagatttga cagatagcat ggagcaatat ggaatcgaaa taacgaagca tgggaaatac   180
tatattttga ctggagagtt ggatgatttg ccgacagaac ttgaagtgtt agttgagtat   240
agtccccaag aaagacaaga gttgattacc tatcgccttc tgactgagag tggttttgtc   300
accaatgaag cattgcaaga gtgcacgaaa gtcagtaatg taactattat tcaggatatt   360
tcagatattg ataagcgtct tttagacttt gatctgaaaa ttgaacgaca aaaaggttat   420
cggatttctg gtgattcagt tggtaagaga agatttttgg ctattttact gacaaactgt   480
atctcagtag cagatttttc aaccggtaat tttgggagct ttgatatttt agaagcagat   540
agaactgggc tggccagtca gattgttaat aagcaactgt caggttttcc agatatggat   600
gctaggatga agatgttttt tgcgatcttg ttatctctta taggtcagga gcaaaacatt   660
gaaaattcac ctaatactag taagcaggct ttggaaattt ctcaaaaaat ttttcaagct   720
tactctaagc agactgcaca attttatagt attcaggaaa ttatctattt tgcgagcatc   780
ttggatgaat taatcattaa acgtcaggac aatccgctct ttacggagaa atttgatggt   840
gaatttttct acaatatttc aaatctgatt gatacggttt ccatgtatac caagattgac   900
ttttttaagg acaaggtttt attcaatttt cttttccatc atattcggct cagtttaggc   960
gtccctatcc tttttcaggg tgaaaatttg ccagaatcta tccagatttt agttgaaagg   1020
aataaatttc tttatacagt catcagtctt ttagtgaatg atatttttcc gaaatatctt   1080
catacagagt atgagtatgg catgattgcc ctacatttta tctctagctt aggccgtagt   1140
ccagagattt atccagtccg tgttttgctt ttaacggatg aacgtcgggt cactagagat   1200
ttattagtca gtaaaattaa gagtgttgct ccttttgtag agttgataga tattcaatct   1260
ctagtagatt accacagtat tgatctcagt cagtatgatt atattttatc taccaagccg   1320
ctgactaatc aggaaatcga tgtaatttct agttttccaa ccgtcaaaga attgcttgaa   1380
ttacaggaac gacttcagta tgtacaggca catcgtacaa ttgtcgcgcg tgatgctatc   1440
gctccagaga aaagttatga cttgcaagat tatttaatat ctagtagtca gcttttgagt   1500
caattcgagt tggttcaatt ggagaataat caatcatttg agcacacggt agaacaaatc   1560
atccaatatc agaagaatgt gagtgacaga gcttacctaa caagaaaatt gttatctcac   1620
ttccagaata gtcctatggc tattcctaat actggtctgg tgcttttaca tagtcagtct   1680
agcaaagtaa caacaaatag ttttactatg tttgaactca aactacctat ctccgcattg   1740
tcaatgaaac gagaggaaga agaggtcaaa aggtgtctgc taatgctaat gtctaaagaa   1800
gctagcgagg aagctagaga tttaatgaca gctattagtc agtcgattat tgaaaatcat   1860
ctttatacag agatttacaa gacgggaaat caatccatta tttatcagat gctaaatact   1920
atttttaacg aaaaaattaa gaaattggag aac                                1953

<210>   630
<211>   651
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902401 (0.E+01)

<400>   630
Met Leu Leu Thr Lys Arg Glu Glu Gln Leu Leu Lys Ala Phe Leu His 
1               5                   10                  15      

Val Gly Lys Leu Ser Met Gln Asp Met Thr Glu Ile Leu Gln Val Ser 
            20                  25                  30          

Ser Arg Thr Ile Tyr Arg Thr Leu Ser Asp Leu Thr Asp Ser Met Glu 
        35                  40                  45              

Gln Tyr Gly Ile Glu Ile Thr Lys His Gly Lys Tyr Tyr Ile Leu Thr 
    50                  55                  60                  

Gly Glu Leu Asp Asp Leu Pro Thr Glu Leu Glu Val Leu Val Glu Tyr 
65                  70                  75                  80  

Ser Pro Gln Glu Arg Gln Glu Leu Ile Thr Tyr Arg Leu Leu Thr Glu 
                85                  90                  95      

Ser Gly Phe Val Thr Asn Glu Ala Leu Gln Glu Cys Thr Lys Val Ser 
            100                 105                 110         

Asn Val Thr Ile Ile Gln Asp Ile Ser Asp Ile Asp Lys Arg Leu Leu 
        115                 120                 125             

Asp Phe Asp Leu Lys Ile Glu Arg Gln Lys Gly Tyr Arg Ile Ser Gly 
    130                 135                 140                 

Asp Ser Val Gly Lys Arg Arg Phe Leu Ala Ile Leu Leu Thr Asn Cys 
145                 150                 155                 160 

Ile Ser Val Ala Asp Phe Ser Thr Gly Asn Phe Gly Ser Phe Asp Ile 
                165                 170                 175     

Leu Glu Ala Asp Arg Thr Gly Leu Ala Ser Gln Ile Val Asn Lys Gln 
            180                 185                 190         

Leu Ser Gly Phe Pro Asp Met Asp Ala Arg Met Lys Met Phe Phe Ala 
        195                 200                 205             

Ile Leu Leu Ser Leu Ile Gly Gln Glu Gln Asn Ile Glu Asn Ser Pro 
    210                 215                 220                 

Asn Thr Ser Lys Gln Ala Leu Glu Ile Ser Gln Lys Ile Phe Gln Ala 
225                 230                 235                 240 

Tyr Ser Lys Gln Thr Ala Gln Phe Tyr Ser Ile Gln Glu Ile Ile Tyr 
                245                 250                 255     

Phe Ala Ser Ile Leu Asp Glu Leu Ile Ile Lys Arg Gln Asp Asn Pro 
            260                 265                 270         

Leu Phe Thr Glu Lys Phe Asp Gly Glu Phe Phe Tyr Asn Ile Ser Asn 
        275                 280                 285             

Leu Ile Asp Thr Val Ser Met Tyr Thr Lys Ile Asp Phe Phe Lys Asp 
    290                 295                 300                 

Lys Val Leu Phe Asn Phe Leu Phe His His Ile Arg Leu Ser Leu Gly 
305                 310                 315                 320 

Val Pro Ile Leu Phe Gln Gly Glu Asn Leu Pro Glu Ser Ile Gln Ile 
                325                 330                 335     

Leu Val Glu Arg Asn Lys Phe Leu Tyr Thr Val Ile Ser Leu Leu Val 
            340                 345                 350         

Asn Asp Ile Phe Pro Lys Tyr Leu His Thr Glu Tyr Glu Tyr Gly Met 
        355                 360                 365             

Ile Ala Leu His Phe Ile Ser Ser Leu Gly Arg Ser Pro Glu Ile Tyr 
    370                 375                 380                 

Pro Val Arg Val Leu Leu Leu Thr Asp Glu Arg Arg Val Thr Arg Asp 
385                 390                 395                 400 

Leu Leu Val Ser Lys Ile Lys Ser Val Ala Pro Phe Val Glu Leu Ile 
                405                 410                 415     

Asp Ile Gln Ser Leu Val Asp Tyr His Ser Ile Asp Leu Ser Gln Tyr 
            420                 425                 430         

Asp Tyr Ile Leu Ser Thr Lys Pro Leu Thr Asn Gln Glu Ile Asp Val 
        435                 440                 445             

Ile Ser Ser Phe Pro Thr Val Lys Glu Leu Leu Glu Leu Gln Glu Arg 
    450                 455                 460                 

Leu Gln Tyr Val Gln Ala His Arg Thr Ile Val Ala Arg Asp Ala Ile 
465                 470                 475                 480 

Ala Pro Glu Lys Ser Tyr Asp Leu Gln Asp Tyr Leu Ile Ser Ser Ser 
                485                 490                 495     

Gln Leu Leu Ser Gln Phe Glu Leu Val Gln Leu Glu Asn Asn Gln Ser 
            500                 505                 510         

Phe Glu His Thr Val Glu Gln Ile Ile Gln Tyr Gln Lys Asn Val Ser 
        515                 520                 525             

Asp Arg Ala Tyr Leu Thr Arg Lys Leu Leu Ser His Phe Gln Asn Ser 
    530                 535                 540                 

Pro Met Ala Ile Pro Asn Thr Gly Leu Val Leu Leu His Ser Gln Ser 
545                 550                 555                 560 

Ser Lys Val Thr Thr Asn Ser Phe Thr Met Phe Glu Leu Lys Leu Pro 
                565                 570                 575     

Ile Ser Ala Leu Ser Met Lys Arg Glu Glu Glu Glu Val Lys Arg Cys 
            580                 585                 590         

Leu Leu Met Leu Met Ser Lys Glu Ala Ser Glu Glu Ala Arg Asp Leu 
        595                 600                 605             

Met Thr Ala Ile Ser Gln Ser Ile Ile Glu Asn His Leu Tyr Thr Glu 
    610                 615                 620                 

Ile Tyr Lys Thr Gly Asn Gln Ser Ile Ile Tyr Gln Met Leu Asn Thr 
625                 630                 635                 640 

Ile Phe Asn Glu Lys Ile Lys Lys Leu Glu Asn 
                645                 650     

<210>   631
<211>   435
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   631
atgaaacttg aaaaacattt gattaagctt aataaacaat tttctaacaa ggaggaagct   60
atttgttatt gtgggcaagt tctttatgag ggtggatatg ttaatgaaga ctatattgaa   120
gccatgattg agcgagataa agagctatct gtttacatgg gtaactttat cgccataccg   180
catggaacag atgcagcaaa aaatgatgtc ctcaagtctg gtattacagt cgttcaagtc   240
cctagagggg ttgattttgg gaatgtatct aaccctcaag tggcaacggt tctttttggt   300
attgctggta ttggtaatga acacttagaa attattcaga aaatttctat cttctgtgca   360
gatgtagata atgttcttaa actagcagat gctcagtcaa aagaggaagt attgcgctta   420
tttgatgctg ttgaa                                                    435

<210>   632
<211>   145
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, mannitol-specific IIA component (mtlF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902402 (3.E-80)

<400>   632
Met Lys Leu Glu Lys His Leu Ile Lys Leu Asn Lys Gln Phe Ser Asn 
1               5                   10                  15      

Lys Glu Glu Ala Ile Cys Tyr Cys Gly Gln Val Leu Tyr Glu Gly Gly 
            20                  25                  30          

Tyr Val Asn Glu Asp Tyr Ile Glu Ala Met Ile Glu Arg Asp Lys Glu 
        35                  40                  45              

Leu Ser Val Tyr Met Gly Asn Phe Ile Ala Ile Pro His Gly Thr Asp 
    50                  55                  60                  

Ala Ala Lys Asn Asp Val Leu Lys Ser Gly Ile Thr Val Val Gln Val 
65                  70                  75                  80  

Pro Arg Gly Val Asp Phe Gly Asn Val Ser Asn Pro Gln Val Ala Thr 
                85                  90                  95      

Val Leu Phe Gly Ile Ala Gly Ile Gly Asn Glu His Leu Glu Ile Ile 
            100                 105                 110         

Gln Lys Ile Ser Ile Phe Cys Ala Asp Val Asp Asn Val Leu Lys Leu 
        115                 120                 125             

Ala Asp Ala Gln Ser Lys Glu Glu Val Leu Arg Leu Phe Asp Ala Val 
    130                 135                 140                 

Glu 
145 

<210>   633
<211>   1134
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   633
atgaaacatt ctgttcattt tggtgccggt aatatcggtc gtggttttat aggtgaaatt   60
ctatttaaaa atggtttcca tattgatttt gtggatgtca ataatcagat aattcatgct   120
ctgaatgaaa agggcaagta tgaaattgaa attgcacaga aaggacagtc tcgtatagaa   180
gtaactaatg tggctggcat taatagcaaa gaacatcctg agcaagtcat tgaagcgatt   240
caaaagacgg atattattac tactgcaatc ggacctaata tactcccttt tatcgccgaa   300
cttctagcca aaggaatcga agctcgccga gttgcaggaa atacacaggc attggatgtt   360
atggcctgtg aaaatatgat tggcgggtct caatttcttt atcaagaagt caagaaatat   420
ttaagtccgg aaggtttgac atttgctgat aactacatag gttttccaaa tgctgcagta   480
gacaggattg ttccagcaca aagtcacgaa gattcccttt ttgttgtggt cgagcccttt   540
aatgaatggg tcgtggaaac caagcgtctt aaaaatccag atttacgtct aaaagatgtg   600
cattatgaag aagatttaga accctttatt gagcgaaaac ttttttcagt caattctgga   660
catgcaactt cagcttacat tggtgcgcat tatggtgcca agacaatttt ggaagctctt   720
caaaatccta atattaaatc tcggattgaa tctgtattag ctgaaattcg gagtctcttg   780
attgccaaat ggaactttga taaaaaagaa ttggagaatt atcacaaagt cattatagaa   840
cgacttgaaa accctttcat agtggacgag gttagtcgcg tagctcgtac tccaatccga   900
aaattaggct ataatgaacg attcatccgg ccgatacgtg aattgaaaga actcagtttg   960
tcatataaaa acctacttaa aacagttggc tatgtctttg actatcgcga tgtaaatgat   1020
gaagaaagta ttcgattagg tgaattgttg gctaaacaat cagtcaaaga tgttgttata   1080
caagttacag gtttagacga ccaagaattg attgagcaaa ttgtagagta tatt         1134

<210>   634
<211>   378
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   mannitol-1-phosphate 5-dehydrogenase (mtlD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902403 (0.E+01)

<400>   634
Met Lys His Ser Val His Phe Gly Ala Gly Asn Ile Gly Arg Gly Phe 
1               5                   10                  15      

Ile Gly Glu Ile Leu Phe Lys Asn Gly Phe His Ile Asp Phe Val Asp 
            20                  25                  30          

Val Asn Asn Gln Ile Ile His Ala Leu Asn Glu Lys Gly Lys Tyr Glu 
        35                  40                  45              

Ile Glu Ile Ala Gln Lys Gly Gln Ser Arg Ile Glu Val Thr Asn Val 
    50                  55                  60                  

Ala Gly Ile Asn Ser Lys Glu His Pro Glu Gln Val Ile Glu Ala Ile 
65                  70                  75                  80  

Gln Lys Thr Asp Ile Ile Thr Thr Ala Ile Gly Pro Asn Ile Leu Pro 
                85                  90                  95      

Phe Ile Ala Glu Leu Leu Ala Lys Gly Ile Glu Ala Arg Arg Val Ala 
            100                 105                 110         

Gly Asn Thr Gln Ala Leu Asp Val Met Ala Cys Glu Asn Met Ile Gly 
        115                 120                 125             

Gly Ser Gln Phe Leu Tyr Gln Glu Val Lys Lys Tyr Leu Ser Pro Glu 
    130                 135                 140                 

Gly Leu Thr Phe Ala Asp Asn Tyr Ile Gly Phe Pro Asn Ala Ala Val 
145                 150                 155                 160 

Asp Arg Ile Val Pro Ala Gln Ser His Glu Asp Ser Leu Phe Val Val 
                165                 170                 175     

Val Glu Pro Phe Asn Glu Trp Val Val Glu Thr Lys Arg Leu Lys Asn 
            180                 185                 190         

Pro Asp Leu Arg Leu Lys Asp Val His Tyr Glu Glu Asp Leu Glu Pro 
        195                 200                 205             

Phe Ile Glu Arg Lys Leu Phe Ser Val Asn Ser Gly His Ala Thr Ser 
    210                 215                 220                 

Ala Tyr Ile Gly Ala His Tyr Gly Ala Lys Thr Ile Leu Glu Ala Leu 
225                 230                 235                 240 

Gln Asn Pro Asn Ile Lys Ser Arg Ile Glu Ser Val Leu Ala Glu Ile 
                245                 250                 255     

Arg Ser Leu Leu Ile Ala Lys Trp Asn Phe Asp Lys Lys Glu Leu Glu 
            260                 265                 270         

Asn Tyr His Lys Val Ile Ile Glu Arg Leu Glu Asn Pro Phe Ile Val 
        275                 280                 285             

Asp Glu Val Ser Arg Val Ala Arg Thr Pro Ile Arg Lys Leu Gly Tyr 
    290                 295                 300                 

Asn Glu Arg Phe Ile Arg Pro Ile Arg Glu Leu Lys Glu Leu Ser Leu 
305                 310                 315                 320 

Ser Tyr Lys Asn Leu Leu Lys Thr Val Gly Tyr Val Phe Asp Tyr Arg 
                325                 330                 335     

Asp Val Asn Asp Glu Glu Ser Ile Arg Leu Gly Glu Leu Leu Ala Lys 
            340                 345                 350         

Gln Ser Val Lys Asp Val Val Ile Gln Val Thr Gly Leu Asp Asp Gln 
        355                 360                 365             

Glu Leu Ile Glu Gln Ile Val Glu Tyr Ile 
    370                 375             

<210>   635
<211>   156
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   635
ttgtctttga tttttgttgt tatttataag gtaaaagaag ctggacaaaa agtcttcaaa   60
atcgggaaaa ggcagcctat cgggtgttca aaaatcttga taggatgtcc tttattatgg   120
aaagccttat tggattttct cctcagattg agtttt                             156

<210>   636
<211>   52
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902404 (1.E-25)

<400>   636
Met Ser Leu Ile Phe Val Val Ile Tyr Lys Val Lys Glu Ala Gly Gln 
1               5                   10                  15      

Lys Val Phe Lys Ile Gly Lys Arg Gln Pro Ile Gly Cys Ser Lys Ile 
            20                  25                  30          

Leu Ile Gly Cys Pro Leu Leu Trp Lys Ala Leu Leu Asp Phe Leu Leu 
        35                  40                  45              

Arg Leu Ser Phe 
    50          

<210>   637
<211>   156
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   637
tatgagatag gtcttgctag agatgtagcc catcatgtta tttttatgga cagtgggaaa   60
attgttgaaa aaaataatgc ccatcaattc tttagtcgtc caagagaaga acgaaccaag   120
caattttgga acgaattctt tcgaatgcga tctata                             156

<210>   638
<211>   52
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamine ABC transporter, ATP-binding protein, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902405 (3.E-17)

<400>   638
Tyr Glu Ile Gly Leu Ala Arg Asp Val Ala His His Val Ile Phe Met 
1               5                   10                  15      

Asp Ser Gly Lys Ile Val Glu Lys Asn Asn Ala His Gln Phe Phe Ser 
            20                  25                  30          

Arg Pro Arg Glu Glu Arg Thr Lys Gln Phe Trp Asn Glu Phe Phe Arg 
        35                  40                  45              

Met Arg Ser Ile 
    50          

<210>   639
<211>   1281
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   639
atgtctgtat catttgaaaa caaagaaaca aaccgtggtg tcttgacttt cactatctct   60
caagaccaaa tcaaaccaga attggaccgt gtcttcaagt cagtgaagaa atctcttaat   120
gttccaggtt tccgtaaagg tcaccttcca cgccctatct tcgaccaaaa atttggtgaa   180
gaagctcttt atcaagatgc aatgaacgca cttttgccaa acgcttatga agcagctgta   240
aaagaagctg gtcttgaagt ggttgcccaa ccaaaaattg acgtaacttc aatggaaaaa   300
ggtcaagact gggttatcac tgctgaagtc gttacaaaac ctgaagtaaa attgggtgac   360
tacaaaaacc ttgaagtatc agttgatgta gaaaaagaag taactgacgc tgatgtcgaa   420
gagcgtatcg aacgcgaacg caacaacctg gctgaattgg ttatcaagga agctgctgct   480
gaaaacggcg acactgttgt gatcgacttc gttggttcta tcgacggtgt tgaatttgac   540
ggtggaaaag gtgaaaactt ctcacttgga cttggttcag gtcaattcat ccctggtttc   600
gaagaccaat tggtaggtca ctcagctggc gaaaccgttg atgttatcgt aacattccca   660
gaagactacc aagcagaaga ccttgcaggt aaagaagcta aattcgtgac aactatccac   720
gaagtaaaag ctaaagaagt tccggctctt gacgatgaac ttgcaaaaga cattgatgaa   780
gaagttgaaa cacttgctga cttgaaagaa aaatacagca aagaattggc tgctgctaaa   840
gaagaagctt acaaagatgc agttgaaggt gcagcaattg atacagctgt agaaaatgct   900
gaaatcgtag aacttccaga agaaatgatc catgaagaag ttcaccgttc agtaaatgaa   960
ttccttggga atttgcaacg tcaagggatc aaccctgaca tgtacttcca aatcactgga   1020
actactcaag aagaccttca caaccaatac caagcagaag ctgagtcacg tactaagact   1080
aaccttgtta tcgaagcagt tgccaaagct gaaggatttg atgcttcaga agaagaaatc   1140
caaaaagaag ttgagcaatt ggcagcagac tacaacatgg aagttgcaca agttcaaaac   1200
ttgctttcag ctgacatgtt gaaacatgat atcactatca aaaaagctgt tgaattgatc   1260
acaagcacag caacagtaaa a                                             1281

<210>   640
<211>   427
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   trigger factor (tig)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902406 (0.E+01)

<400>   640
Met Ser Val Ser Phe Glu Asn Lys Glu Thr Asn Arg Gly Val Leu Thr 
1               5                   10                  15      

Phe Thr Ile Ser Gln Asp Gln Ile Lys Pro Glu Leu Asp Arg Val Phe 
            20                  25                  30          

Lys Ser Val Lys Lys Ser Leu Asn Val Pro Gly Phe Arg Lys Gly His 
        35                  40                  45              

Leu Pro Arg Pro Ile Phe Asp Gln Lys Phe Gly Glu Glu Ala Leu Tyr 
    50                  55                  60                  

Gln Asp Ala Met Asn Ala Leu Leu Pro Asn Ala Tyr Glu Ala Ala Val 
65                  70                  75                  80  

Lys Glu Ala Gly Leu Glu Val Val Ala Gln Pro Lys Ile Asp Val Thr 
                85                  90                  95      

Ser Met Glu Lys Gly Gln Asp Trp Val Ile Thr Ala Glu Val Val Thr 
            100                 105                 110         

Lys Pro Glu Val Lys Leu Gly Asp Tyr Lys Asn Leu Glu Val Ser Val 
        115                 120                 125             

Asp Val Glu Lys Glu Val Thr Asp Ala Asp Val Glu Glu Arg Ile Glu 
    130                 135                 140                 

Arg Glu Arg Asn Asn Leu Ala Glu Leu Val Ile Lys Glu Ala Ala Ala 
145                 150                 155                 160 

Glu Asn Gly Asp Thr Val Val Ile Asp Phe Val Gly Ser Ile Asp Gly 
                165                 170                 175     

Val Glu Phe Asp Gly Gly Lys Gly Glu Asn Phe Ser Leu Gly Leu Gly 
            180                 185                 190         

Ser Gly Gln Phe Ile Pro Gly Phe Glu Asp Gln Leu Val Gly His Ser 
        195                 200                 205             

Ala Gly Glu Thr Val Asp Val Ile Val Thr Phe Pro Glu Asp Tyr Gln 
    210                 215                 220                 

Ala Glu Asp Leu Ala Gly Lys Glu Ala Lys Phe Val Thr Thr Ile His 
225                 230                 235                 240 

Glu Val Lys Ala Lys Glu Val Pro Ala Leu Asp Asp Glu Leu Ala Lys 
                245                 250                 255     

Asp Ile Asp Glu Glu Val Glu Thr Leu Ala Asp Leu Lys Glu Lys Tyr 
            260                 265                 270         

Ser Lys Glu Leu Ala Ala Ala Lys Glu Glu Ala Tyr Lys Asp Ala Val 
        275                 280                 285             

Glu Gly Ala Ala Ile Asp Thr Ala Val Glu Asn Ala Glu Ile Val Glu 
    290                 295                 300                 

Leu Pro Glu Glu Met Ile His Glu Glu Val His Arg Ser Val Asn Glu 
305                 310                 315                 320 

Phe Leu Gly Asn Leu Gln Arg Gln Gly Ile Asn Pro Asp Met Tyr Phe 
                325                 330                 335     


Gln Ile Thr Gly Thr Thr Gln Glu Asp Leu His Asn Gln Tyr Gln Ala 
            340                 345                 350         

Glu Ala Glu Ser Arg Thr Lys Thr Asn Leu Val Ile Glu Ala Val Ala 
        355                 360                 365             

Lys Ala Glu Gly Phe Asp Ala Ser Glu Glu Glu Ile Gln Lys Glu Val 
    370                 375                 380                 

Glu Gln Leu Ala Ala Asp Tyr Asn Met Glu Val Ala Gln Val Gln Asn 
385                 390                 395                 400 

Leu Leu Ser Ala Asp Met Leu Lys His Asp Ile Thr Ile Lys Lys Ala 
                405                 410                 415     

Val Glu Leu Ile Thr Ser Thr Ala Thr Val Lys 
            420                 425         

<210>   641
<211>   2364
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   641
atggaagttt atttttcagg aactattgaa cggattattt ttgaaaatcc cagcaatttt   60
tatcgcatcc tcctcctaga aatcgacgat acggacgcag aggattttga tgattttgaa   120
atcattgtca caggaaccat ggctgatgta attgagggcg aagactatac tttttggggg   180
caaattgtcc agcactccaa gtatggagaa caactgcaaa tcagtcgtta tgatcgcgca   240
aaaccaacta gtaagggctt ggtcaagtac ttttcaagta gccatttcaa ggggattggt   300
ctcaagacag ctcagaaaat cgtggatacc tatggcgaaa ataccattga cgaaattttg   360
caacacccag aaaagttaga aggcatcgca ggactctctg ccaaaaatcg cgaggctttc   420
gtctccactc tccgtctcaa ctacggaacg gagatgattt tggccaaact agccaactac   480
ggcattccca acaaactagc ctttcagatt caagactttt acaaggaaga aacccttgat   540
gtggttgaaa attatcccta ccagctggtt gaggatatca agggtttggg ctttaccatt   600
gctgaccaac tagctgagga actaggcatc gaaagtcagg ctcctgaacg cttccgcgcc   660
ggtctagttc acagtctttt tcaggcctgt atggaaacag gggacaccta tgttgaagca   720
cgggatttgc tggaacaaac ccttactctc cttgagtctt cccgtcccgt ggaactagac   780
cccagccaag ttgcccaaga gctctcctac ctgatcgaag aagacaaggt tcagcagatt   840
gataccaaga tctttgacaa cagcctcttt ttcgctgagg aaggcatccg cagtcacttg   900
gttcgtatcc ttgaaaaagg aaaacagaag agtcatgatt tagaaaccat tcaaaaacat   960
atcactactg tcgagcaaga actgggaatt gagtatgata acattcaaaa acaggctatc   1020
tgtgatgcta tccagaataa ggtctttatc ctgacaggtg ggcctggtac tggtaagaca   1080
actgttatca atggaatcat tgctgtttat gcccttttag aaggacttga cttcaggaag   1140
aaaagcaatc tgcccattct tcttgctgct ccaactggtc gagctgctcg tcgcatgaat   1200
gaattgacag gtttgcctag cgcgaccata catcgccact tgggaatgac aggtgacgat   1260
gataccagtc atctggaaga ttacctagat gctgacttta tcatcgtgga tgaattctct   1320
atggtagata cttggctggc caatcaactc ttctccaata tctcttctaa cagtaagatc   1380
ctcatcgtag gtgacagtga tcagctacct tctgtcagtc ctggacaggt tctagcggat   1440
ctacttcata ttcctttgat tcctcagact cgcttggaaa aaatttatcg acaaagcaaa   1500
gaatcaacca tcgtcaccct agctagtcag attcgacagg gcatcttgcc agctgatttc   1560
acccaaaaaa aagctgaccg ttcctacttt gaaattgcta gtggccatat tcctgccacc   1620
attgaaaaaa tcttaggtgc cgccctcaga aatggtattc ccgcccgtga tatccaagtt   1680
ctggctccta tgtaccgagg gacggcaggg attgatgcta tcaatcagct catgcaagac   1740
ctgctcaatc ccccacaaaa agatcaactc agttttgaag ctcctcagtg tcactatcgt   1800
aagagagaca gggtcattca tttggttaac gatgctgaaa tcaatgtctt taatggggat   1860
ttaggagcta tcacagacct gattcctggt aaatacaccg aatcgaaaca agacgagatt   1920
gtcattgatt ttgatggtaa tgaagtctct tacccccgta acgaatggta caagattcgc   1980
ttggcctatg ccatgagtat tcataagtct cagggaagtg agttcccagt tgtcatccta   2040
ccgattacta gtgctagccg acgtatgctg gagcgaaatc tcatctacac agccattaca   2100
cgtgccaaaa gcaaactcat cttactaggc gaattacaag ccttcgacta tgctacccaa   2160
cacatcggaa ctgcccgaaa aacctatctg attgaacgct tcagtgatct actggagaat   2220
gttgaagaaa agcaacaagc tgtctctgaa acagtcacat caagtgcctc tgaacaatcc   2280
tacatcctaa ccgaagaaaa ctgggaccgc atcccagcca tgattgggat tacagacaca   2340
gacctcaaag agatttttgg aaaa                                          2364

<210>   642
<211>   788
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   helicase, putative ( )
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902407 (0.E+01)

<400>   642
Met Glu Val Tyr Phe Ser Gly Thr Ile Glu Arg Ile Ile Phe Glu Asn 
1               5                   10                  15      

Pro Ser Asn Phe Tyr Arg Ile Leu Leu Leu Glu Ile Asp Asp Thr Asp 
            20                  25                  30          

Ala Glu Asp Phe Asp Asp Phe Glu Ile Ile Val Thr Gly Thr Met Ala 
        35                  40                  45              

Asp Val Ile Glu Gly Glu Asp Tyr Thr Phe Trp Gly Gln Ile Val Gln 
    50                  55                  60                  

His Ser Lys Tyr Gly Glu Gln Leu Gln Ile Ser Arg Tyr Asp Arg Ala 
65                  70                  75                  80  

Lys Pro Thr Ser Lys Gly Leu Val Lys Tyr Phe Ser Ser Ser His Phe 
                85                  90                  95      

Lys Gly Ile Gly Leu Lys Thr Ala Gln Lys Ile Val Asp Thr Tyr Gly 
            100                 105                 110         

Glu Asn Thr Ile Asp Glu Ile Leu Gln His Pro Glu Lys Leu Glu Gly 
        115                 120                 125             

Ile Ala Gly Leu Ser Ala Lys Asn Arg Glu Ala Phe Val Ser Thr Leu 
    130                 135                 140                 

Arg Leu Asn Tyr Gly Thr Glu Met Ile Leu Ala Lys Leu Ala Asn Tyr 
145                 150                 155                 160 

Gly Ile Pro Asn Lys Leu Ala Phe Gln Ile Gln Asp Phe Tyr Lys Glu 
                165                 170                 175     

Glu Thr Leu Asp Val Val Glu Asn Tyr Pro Tyr Gln Leu Val Glu Asp 
            180                 185                 190         

Ile Lys Gly Leu Gly Phe Thr Ile Ala Asp Gln Leu Ala Glu Glu Leu 
        195                 200                 205             

Gly Ile Glu Ser Gln Ala Pro Glu Arg Phe Arg Ala Gly Leu Val His 
    210                 215                 220                 

Ser Leu Phe Gln Ala Cys Met Glu Thr Gly Asp Thr Tyr Val Glu Ala 
225                 230                 235                 240 

Arg Asp Leu Leu Glu Gln Thr Leu Thr Leu Leu Glu Ser Ser Arg Pro 
                245                 250                 255     

Val Glu Leu Asp Pro Ser Gln Val Ala Gln Glu Leu Ser Tyr Leu Ile 
            260                 265                 270         

Glu Glu Asp Lys Val Gln Gln Ile Asp Thr Lys Ile Phe Asp Asn Ser 
        275                 280                 285             

Leu Phe Phe Ala Glu Glu Gly Ile Arg Ser His Leu Val Arg Ile Leu 
    290                 295                 300                 

Glu Lys Gly Lys Gln Lys Ser His Asp Leu Glu Thr Ile Gln Lys His 
305                 310                 315                 320 

Ile Thr Thr Val Glu Gln Glu Leu Gly Ile Glu Tyr Asp Asn Ile Gln 
                325                 330                 335     

Lys Gln Ala Ile Cys Asp Ala Ile Gln Asn Lys Val Phe Ile Leu Thr 
            340                 345                 350         

Gly Gly Pro Gly Thr Gly Lys Thr Thr Val Ile Asn Gly Ile Ile Ala 
        355                 360                 365             

Val Tyr Ala Leu Leu Glu Gly Leu Asp Phe Arg Lys Lys Ser Asn Leu 
    370                 375                 380                 

Pro Ile Leu Leu Ala Ala Pro Thr Gly Arg Ala Ala Arg Arg Met Asn 
385                 390                 395                 400 

Glu Leu Thr Gly Leu Pro Ser Ala Thr Ile His Arg His Leu Gly Met 
                405                 410                 415     

Thr Gly Asp Asp Asp Thr Ser His Leu Glu Asp Tyr Leu Asp Ala Asp 
            420                 425                 430         

Phe Ile Ile Val Asp Glu Phe Ser Met Val Asp Thr Trp Leu Ala Asn 
        435                 440                 445             

Gln Leu Phe Ser Asn Ile Ser Ser Asn Ser Lys Ile Leu Ile Val Gly 
    450                 455                 460                 

Asp Ser Asp Gln Leu Pro Ser Val Ser Pro Gly Gln Val Leu Ala Asp 
465                 470                 475                 480 

Leu Leu His Ile Pro Leu Ile Pro Gln Thr Arg Leu Glu Lys Ile Tyr 
                485                 490                 495     

Arg Gln Ser Lys Glu Ser Thr Ile Val Thr Leu Ala Ser Gln Ile Arg 
            500                 505                 510         

Gln Gly Ile Leu Pro Ala Asp Phe Thr Gln Lys Lys Ala Asp Arg Ser 
        515                 520                 525             

Tyr Phe Glu Ile Ala Ser Gly His Ile Pro Ala Thr Ile Glu Lys Ile 
    530                 535                 540                 

Leu Gly Ala Ala Leu Arg Asn Gly Ile Pro Ala Arg Asp Ile Gln Val 
545                 550                 555                 560 

Leu Ala Pro Met Tyr Arg Gly Thr Ala Gly Ile Asp Ala Ile Asn Gln 
                565                 570                 575     

Leu Met Gln Asp Leu Leu Asn Pro Pro Gln Lys Asp Gln Leu Ser Phe 
            580                 585                 590         

Glu Ala Pro Gln Cys His Tyr Arg Lys Arg Asp Arg Val Ile His Leu 
        595                 600                 605             

Val Asn Asp Ala Glu Ile Asn Val Phe Asn Gly Asp Leu Gly Ala Ile 
    610                 615                 620                 

Thr Asp Leu Ile Pro Gly Lys Tyr Thr Glu Ser Lys Gln Asp Glu Ile 
625                 630                 635                 640 

Val Ile Asp Phe Asp Gly Asn Glu Val Ser Tyr Pro Arg Asn Glu Trp 
                645                 650                 655     

Tyr Lys Ile Arg Leu Ala Tyr Ala Met Ser Ile His Lys Ser Gln Gly 
            660                 665                 670         

Ser Glu Phe Pro Val Val Ile Leu Pro Ile Thr Ser Ala Ser Arg Arg 
        675                 680                 685             

Met Leu Glu Arg Asn Leu Ile Tyr Thr Ala Ile Thr Arg Ala Lys Ser 
    690                 695                 700                 

Lys Leu Ile Leu Leu Gly Glu Leu Gln Ala Phe Asp Tyr Ala Thr Gln 
705                 710                 715                 720 

His Ile Gly Thr Ala Arg Lys Thr Tyr Leu Ile Glu Arg Phe Ser Asp 
                725                 730                 735     

Leu Leu Glu Asn Val Glu Glu Lys Gln Gln Ala Val Ser Glu Thr Val 
            740                 745                 750         

Thr Ser Ser Ala Ser Glu Gln Ser Tyr Ile Leu Thr Glu Glu Asn Trp 
        755                 760                 765             

Asp Arg Ile Pro Ala Met Ile Gly Ile Thr Asp Thr Asp Leu Lys Glu 
    770                 775                 780                 

Ile Phe Gly Lys 
785             

<210>   643
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   643
ttgtttattt acaaatactc aatgaaaatc aaagaacaaa ctaggaagct agccgtaggc   60
tgcttaaaac agtgttttga ggttgtggat agaactgacg aagtcagctc aaaatactgt   120
tttgaggttg cagatggaag c                                             141

<210>   644
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   644
Met Phe Ile Tyr Lys Tyr Ser Met Lys Ile Lys Glu Gln Thr Arg Lys 
1               5                   10                  15      

Leu Ala Val Gly Cys Leu Lys Gln Cys Phe Glu Val Val Asp Arg Thr 
            20                  25                  30          

Asp Glu Val Ser Ser Lys Tyr Cys Phe Glu Val Ala Asp Gly Ser 
        35                  40                  45          

<210>   645
<211>   612
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   645
atgaattcat ttaaaaattt cttaaaagag tggggattgt tcctcctaat tctgtcatta   60
ctagctttaa gtcgtatctt tttttggagc aatgttcgcg tagaaggaca ttccatggat   120
ccgaccctag cggatggcga aattctcttc gttgtaaaac accttcctat tgaccgtttt   180
gatatcgtgg tggcccatga ggaagatggc aataaggaca tcgtcaagcg cgtgattgga   240
atgcctggcg acaccattcg ttacgaaaat gataaactct acatcaatga caaagaaacg   300
gacgagcctt atctagcaga ctatatcaaa cgcttcaagg atgacaaact ccaaagcact   360
tactcaggca agggctttga aggaaataaa ggaactttct ttagaagtat cgctcaaaaa   420
gctcaagcct tcacagttga tgtcaactac aacaccaact ttagctttac tgttccagaa   480
ggagaatacc ttctcctcgg agatgaccgc ttggtttcga gcgacagccg ccacgtaggt   540
accttcaaag caaaagatat cacaggggaa gctaaattcc gcttatggcc aatcacccgt   600
atcggaacat tt                                                       612

<210>   646
<211>   204
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   signal peptidase I (spi)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902408 (e-117)

<400>   646
Met Asn Ser Phe Lys Asn Phe Leu Lys Glu Trp Gly Leu Phe Leu Leu 
1               5                   10                  15      

Ile Leu Ser Leu Leu Ala Leu Ser Arg Ile Phe Phe Trp Ser Asn Val 
            20                  25                  30          

Arg Val Glu Gly His Ser Met Asp Pro Thr Leu Ala Asp Gly Glu Ile 
        35                  40                  45              

Leu Phe Val Val Lys His Leu Pro Ile Asp Arg Phe Asp Ile Val Val 
    50                  55                  60                  

Ala His Glu Glu Asp Gly Asn Lys Asp Ile Val Lys Arg Val Ile Gly 
65                  70                  75                  80  

Met Pro Gly Asp Thr Ile Arg Tyr Glu Asn Asp Lys Leu Tyr Ile Asn 
                85                  90                  95      

Asp Lys Glu Thr Asp Glu Pro Tyr Leu Ala Asp Tyr Ile Lys Arg Phe 
            100                 105                 110         

Lys Asp Asp Lys Leu Gln Ser Thr Tyr Ser Gly Lys Gly Phe Glu Gly 
        115                 120                 125             

Asn Lys Gly Thr Phe Phe Arg Ser Ile Ala Gln Lys Ala Gln Ala Phe 
    130                 135                 140                 

Thr Val Asp Val Asn Tyr Asn Thr Asn Phe Ser Phe Thr Val Pro Glu 
145                 150                 155                 160 

Gly Glu Tyr Leu Leu Leu Gly Asp Asp Arg Leu Val Ser Ser Asp Ser 
                165                 170                 175     

Arg His Val Gly Thr Phe Lys Ala Lys Asp Ile Thr Gly Glu Ala Lys 
            180                 185                 190         

Phe Arg Leu Trp Pro Ile Thr Arg Ile Gly Thr Phe 
        195                 200                 

<210>   647
<211>   879
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   647
atggcaagta tcacactcac accaagcgaa aaggatattc aggcttttct tgaacactat   60
caaaccagtc tggctcctag caagaatccc tatatccgct actttttgaa actacctcaa   120
gcaacggttt ctatctatac ttctggaaaa atcttgcttc agggtgaagg ggctgaaaaa   180
tacgccagtt tctttggcta tcaagctgta gagcaaacca gcggacaaaa tcttccttta   240
attgggacag atgaggtggg aaatggttcc tactttggtg ggcttgcagt tgtggctgcc   300
tttgtcacac ctgaccagca cgacttttta cgaaaactcg gtgtggggga ttctaagact   360
ctgaccgacc aaaagatccg tcagattact cctattctca aggaaaaaat tcagcaccag   420
gcactccttc tctcacccag caagtacaac gaggtcatcg gagaccgcta caacgctgtt   480
tcggttaagg ttgccctcca taatcaggct atctatctcc tccttcaaaa aggtgttcag   540
cctgagaaaa ttgtgattga tgcctttacc agtgctaaaa attatgacaa gtacttggca   600
caagaggcca atcgtttcag caatcctatc agcttagaag aaaaggctga gggcaaatac   660
ttgtctgtcg cagtttcttc tgtcattgcg cgtgatctct ttctggaaaa tcttgaaaat   720
ttgggacgag aactgggtta tcagctccca agtggagctg gaacggcttc tgacaaggtg   780
gctagccaga ttttgcaagc ctatggtatg cagggactca gcttctgcgc caaattgcac   840
tttaaaaaca ctgaaaaagc gaaaaaacgc ttagaaagg                          879

<210>   648
<211>   293
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribonuclease HIII (rnhC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902409 (e-160)

<400>   648
Met Ala Ser Ile Thr Leu Thr Pro Ser Glu Lys Asp Ile Gln Ala Phe 
1               5                   10                  15      

Leu Glu His Tyr Gln Thr Ser Leu Ala Pro Ser Lys Asn Pro Tyr Ile 
            20                  25                  30          

Arg Tyr Phe Leu Lys Leu Pro Gln Ala Thr Val Ser Ile Tyr Thr Ser 
        35                  40                  45              

Gly Lys Ile Leu Leu Gln Gly Glu Gly Ala Glu Lys Tyr Ala Ser Phe 
    50                  55                  60                  

Phe Gly Tyr Gln Ala Val Glu Gln Thr Ser Gly Gln Asn Leu Pro Leu 
65                  70                  75                  80  

Ile Gly Thr Asp Glu Val Gly Asn Gly Ser Tyr Phe Gly Gly Leu Ala 
                85                  90                  95      

Val Val Ala Ala Phe Val Thr Pro Asp Gln His Asp Phe Leu Arg Lys 
            100                 105                 110         

Leu Gly Val Gly Asp Ser Lys Thr Leu Thr Asp Gln Lys Ile Arg Gln 
        115                 120                 125             

Ile Thr Pro Ile Leu Lys Glu Lys Ile Gln His Gln Ala Leu Leu Leu 
    130                 135                 140                 

Ser Pro Ser Lys Tyr Asn Glu Val Ile Gly Asp Arg Tyr Asn Ala Val 
145                 150                 155                 160 

Ser Val Lys Val Ala Leu His Asn Gln Ala Ile Tyr Leu Leu Leu Gln 
                165                 170                 175     

Lys Gly Val Gln Pro Glu Lys Ile Val Ile Asp Ala Phe Thr Ser Ala 
            180                 185                 190         

Lys Asn Tyr Asp Lys Tyr Leu Ala Gln Glu Ala Asn Arg Phe Ser Asn 
        195                 200                 205             

Pro Ile Ser Leu Glu Glu Lys Ala Glu Gly Lys Tyr Leu Ser Val Ala 
    210                 215                 220                 

Val Ser Ser Val Ile Ala Arg Asp Leu Phe Leu Glu Asn Leu Glu Asn 
225                 230                 235                 240 


Leu Gly Arg Glu Leu Gly Tyr Gln Leu Pro Ser Gly Ala Gly Thr Ala 
                245                 250                 255     

Ser Asp Lys Val Ala Ser Gln Ile Leu Gln Ala Tyr Gly Met Gln Gly 
            260                 265                 270         

Leu Ser Phe Cys Ala Lys Leu His Phe Lys Asn Thr Glu Lys Ala Lys 
        275                 280                 285             

Lys Arg Leu Glu Arg 
    290             

<210>   649
<211>   309
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   649
gtgaatttta tggcaaatct aaatcgattc aaatttacat tcgggaaaaa atcgttaacc   60
ttgacaagcg aacatgacaa cctttttatg gaggaaatcg ctaaggttgc gacagaaaaa   120
taccaagcaa ttaaagaaca aatgcctagc gcagatgatg aaacaatcgc tcttttgttg   180
gcagtcaact gtttatcaac tcagctcagc cgtgagattg aatttgacga taaggagcaa   240
gagctagaag aactccgtca caagcttgtg acttgtaagc aagaacagag caagattgag   300
gattcctta                                                           309

<210>   650
<211>   103
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902410 (2.E-54)

<400>   650
Met Asn Phe Met Ala Asn Leu Asn Arg Phe Lys Phe Thr Phe Gly Lys 
1               5                   10                  15      

Lys Ser Leu Thr Leu Thr Ser Glu His Asp Asn Leu Phe Met Glu Glu 
            20                  25                  30          

Ile Ala Lys Val Ala Thr Glu Lys Tyr Gln Ala Ile Lys Glu Gln Met 
        35                  40                  45              

Pro Ser Ala Asp Asp Glu Thr Ile Ala Leu Leu Leu Ala Val Asn Cys 
    50                  55                  60                  

Leu Ser Thr Gln Leu Ser Arg Glu Ile Glu Phe Asp Asp Lys Glu Gln 
65                  70                  75                  80  

Glu Leu Glu Glu Leu Arg His Lys Leu Val Thr Cys Lys Gln Glu Gln 
                85                  90                  95      

Ser Lys Ile Glu Asp Ser Leu 
            100             

<210>   651
<211>   546
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   651
atgatttcat tccttcttct attggtcttg gtttggggat tttatatcgg ctatcggaga   60
ggcctgctct tacaggttta ttacctgatt tcagccatgg catcggcttt tatggctggc   120
cagttttata aggggcttgg agagcaattc catttattgc tcccttatgc aaattcgcag   180
gaaggtcagg ggactttctt tttcccatcg gatcaactct ttcagctgga taaggtcttt   240
tatgcaggta tcggctactt gcttgtattt gggattgtct atagcattgg tcgtttactt   300
ggtcttctct tacacttgat tcctagcaaa aaactgggtg gtaagttgtt ccaagtttca   360
gcaggtatct tgtccatgtt ggtgacctta tttgtcttgc aaatggcctt gacaatcttg   420
gcgaccatcc ccatggcagt tatacaaaat cctcttgaaa agagtatcgt cgcaaaacac   480
atcatccaga gcataccggt aacaaccagt tggctcaaac aaatctgggt gacaaattta   540
atcgga                                                              546

<210>   652
<211>   182
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902411 (2.E-99)

<400>   652
Met Ile Ser Phe Leu Leu Leu Leu Val Leu Val Trp Gly Phe Tyr Ile 
1               5                   10                  15      

Gly Tyr Arg Arg Gly Leu Leu Leu Gln Val Tyr Tyr Leu Ile Ser Ala 
            20                  25                  30          

Met Ala Ser Ala Phe Met Ala Gly Gln Phe Tyr Lys Gly Leu Gly Glu 
        35                  40                  45              

Gln Phe His Leu Leu Leu Pro Tyr Ala Asn Ser Gln Glu Gly Gln Gly 
    50                  55                  60                  

Thr Phe Phe Phe Pro Ser Asp Gln Leu Phe Gln Leu Asp Lys Val Phe 
65                  70                  75                  80  

Tyr Ala Gly Ile Gly Tyr Leu Leu Val Phe Gly Ile Val Tyr Ser Ile 
                85                  90                  95      

Gly Arg Leu Leu Gly Leu Leu Leu His Leu Ile Pro Ser Lys Lys Leu 
            100                 105                 110         

Gly Gly Lys Leu Phe Gln Val Ser Ala Gly Ile Leu Ser Met Leu Val 
        115                 120                 125             

Thr Leu Phe Val Leu Gln Met Ala Leu Thr Ile Leu Ala Thr Ile Pro 
    130                 135                 140                 

Met Ala Val Ile Gln Asn Pro Leu Glu Lys Ser Ile Val Ala Lys His 
145                 150                 155                 160 

Ile Ile Gln Ser Ile Pro Val Thr Thr Ser Trp Leu Lys Gln Ile Trp 
                165                 170                 175     

Val Thr Asn Leu Ile Gly 
            180         

<210>   653
<211>   2334
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   653
atgaataaga aaatattaga aacattagag ttcgataagg tcaaggcctt gtttgagcct   60
catttgttga ccgagcaggg cttggagcaa ttgagacaac tggctccgac tgccaaagca   120
gataaaatca aacaggcttt tgctgagatg aaggaaatgc aggctctttt cgtcgagcaa   180
ccgcatttta ctattctctc aactaaggaa attgcaggag tctgcaagag gttggagatg   240
ggagcggatc tcaatatcga ggagttccta ctcttgaaac gcgtgcttct tgccagccga   300
gaacttcaaa atttttacac caatctggaa aatgtcagct tggaagaatt agccctttgg   360
tttgagaaat tacatgattt tccgcaatta caaggaaatc ttcaggcctt taatgatgcg   420
ggtttcattg aaaattttgc cagtgaagaa ttggcgcgaa tccgtcgaaa aatacatgat   480
agcgagagtc aggtacgcga tgttttacaa gacttgctca agcaaaaagc gcagctgttg   540
acggaaggaa ttgttgctag cagaaatggc cgtcaggttt taccagtcaa aaacacctac   600
cgcaataaga ttgcaggtgt cgttcatgat atttctgcta gtggaaacac cgtctatatc   660
gaaccccgtg aggtagtcaa actgagcgaa gaaattgcta gtctgcgagc agatgagcgc   720
tatgaaatgc ttcgcattct ccaagaaatt tctgagcgtg tccgccctca tgcggctgag   780
attgctaatg acgcttggat tatcggtcat ctggacttga ttcgtgccaa ggttcgattt   840
atccaagaaa gacaagcagt cgtgcctcag ctgtcagaaa atcaagagat tcaactgctc   900
catgtctgcc atcctttggt caaaaatgcc gtcgcaaatg atgtctattt tggtcaagat   960
ttaacagcta ttgtcattac aggtcccaat acaggtggga agaccatcat gctcaaaact   1020
ctgggcttga cacaggtcat ggcccagtca ggattgccga ttttagcaga caagggaagt   1080
cgtgttggta tttttgaaga aatctttgct gatattggag atgagcagtc tattgagcag   1140
agcttgtcta ccttctctag tcatatgacc aatatcgtgg atattcttgg caaggtcaac   1200
caacattcac tcttactttt ggatgagttg ggggctggta ctgatcccca agagggagca   1260
gcccttgcca tggctattct ggaggacctt cgcctgcgtc aaatcaagac catggcgacg   1320
acccactatc cagaactcaa ggcctacggt attgagacag cctttgtgca aaatgccagt   1380
atggagtttg atactgcaac tcttcgcccg acctatcgct ttatgcaggg tgttcctggc   1440
cgaagtaatg cctttgaaat tgccaaacgt ctaggcctat ctgaagttat cgtaggagat   1500
gccagtcagc agatcgatca ggacaatgac gtcaatcgta tcattgagca attagaagag   1560
cagacgctgg aaagccgcaa acgtttggac aatatccgtg aggtggagca agaaaatctc   1620
aagatgaacc gtgcgctaaa aaaactctac aacgagctta atcgtgaaaa ggaaaccgag   1680
cttaacaagg cgcgtgaaca ggctgctgag attgtggata tggccctaag tgaaagtgac   1740
cagattctca aaaatctcca cagtaaatcc caactcaagc cccacgaaat cattgaagcc   1800
aaggccaagt tgaaaaaatt ggctcctgaa aaagtggact tgtctaaaaa taaggtcctt   1860
caaaaggcca agaaaaaacg agctccaaag gtgggagatg atatcgtggt tctcagttat   1920
ggtcagcgtg gtaccttgac cagtcaactc aaggacggtc gctgggaagc ccaagttggc   1980
ttgattaaga tgaccttgga agagaaagag tttgatcttg ttcaagccca gcaagaaaaa   2040
ccagtcaaga agaaacaggt caatgttgtg aaacgaactt ctgggcgagg acctcaagct   2100
agactggatc ttcgaggcaa gcgctatgaa gaagccatga atgagctaga taccttcatc   2160
gaccaagcct tgcttaacaa tatggctcaa gttgatatca tccatggtat cggaacagga   2220
gtcatccgtg aaggagttac caaatacttg caaagaaaca aacatgtcaa gagtttcggc   2280
tatgccccac aaaatgctgg aggcagtggt gcgactattg tcacttttaa agga         2334

<210>   654
<211>   778
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MutS2 family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902412 (0.E+01)

<400>   654
Met Asn Lys Lys Ile Leu Glu Thr Leu Glu Phe Asp Lys Val Lys Ala 
1               5                   10                  15      

Leu Phe Glu Pro His Leu Leu Thr Glu Gln Gly Leu Glu Gln Leu Arg 
            20                  25                  30          

Gln Leu Ala Pro Thr Ala Lys Ala Asp Lys Ile Lys Gln Ala Phe Ala 
        35                  40                  45              

Glu Met Lys Glu Met Gln Ala Leu Phe Val Glu Gln Pro His Phe Thr 
    50                  55                  60                  

Ile Leu Ser Thr Lys Glu Ile Ala Gly Val Cys Lys Arg Leu Glu Met 
65                  70                  75                  80  

Gly Ala Asp Leu Asn Ile Glu Glu Phe Leu Leu Leu Lys Arg Val Leu 
                85                  90                  95      

Leu Ala Ser Arg Glu Leu Gln Asn Phe Tyr Thr Asn Leu Glu Asn Val 
            100                 105                 110         

Ser Leu Glu Glu Leu Ala Leu Trp Phe Glu Lys Leu His Asp Phe Pro 
        115                 120                 125             

Gln Leu Gln Gly Asn Leu Gln Ala Phe Asn Asp Ala Gly Phe Ile Glu 
    130                 135                 140                 

Asn Phe Ala Ser Glu Glu Leu Ala Arg Ile Arg Arg Lys Ile His Asp 
145                 150                 155                 160 

Ser Glu Ser Gln Val Arg Asp Val Leu Gln Asp Leu Leu Lys Gln Lys 
                165                 170                 175     

Ala Gln Leu Leu Thr Glu Gly Ile Val Ala Ser Arg Asn Gly Arg Gln 
            180                 185                 190         

Val Leu Pro Val Lys Asn Thr Tyr Arg Asn Lys Ile Ala Gly Val Val 
        195                 200                 205             

His Asp Ile Ser Ala Ser Gly Asn Thr Val Tyr Ile Glu Pro Arg Glu 
    210                 215                 220                 

Val Val Lys Leu Ser Glu Glu Ile Ala Ser Leu Arg Ala Asp Glu Arg 
225                 230                 235                 240 

Tyr Glu Met Leu Arg Ile Leu Gln Glu Ile Ser Glu Arg Val Arg Pro 
                245                 250                 255     

His Ala Ala Glu Ile Ala Asn Asp Ala Trp Ile Ile Gly His Leu Asp 
            260                 265                 270         

Leu Ile Arg Ala Lys Val Arg Phe Ile Gln Glu Arg Gln Ala Val Val 
        275                 280                 285             

Pro Gln Leu Ser Glu Asn Gln Glu Ile Gln Leu Leu His Val Cys His 
    290                 295                 300                 

Pro Leu Val Lys Asn Ala Val Ala Asn Asp Val Tyr Phe Gly Gln Asp 
305                 310                 315                 320 

Leu Thr Ala Ile Val Ile Thr Gly Pro Asn Thr Gly Gly Lys Thr Ile 
                325                 330                 335     

Met Leu Lys Thr Leu Gly Leu Thr Gln Val Met Ala Gln Ser Gly Leu 
            340                 345                 350         

Pro Ile Leu Ala Asp Lys Gly Ser Arg Val Gly Ile Phe Glu Glu Ile 
        355                 360                 365             

Phe Ala Asp Ile Gly Asp Glu Gln Ser Ile Glu Gln Ser Leu Ser Thr 
    370                 375                 380                 

Phe Ser Ser His Met Thr Asn Ile Val Asp Ile Leu Gly Lys Val Asn 
385                 390                 395                 400 

Gln His Ser Leu Leu Leu Leu Asp Glu Leu Gly Ala Gly Thr Asp Pro 
                405                 410                 415     

Gln Glu Gly Ala Ala Leu Ala Met Ala Ile Leu Glu Asp Leu Arg Leu 
            420                 425                 430         

Arg Gln Ile Lys Thr Met Ala Thr Thr His Tyr Pro Glu Leu Lys Ala 
        435                 440                 445             

Tyr Gly Ile Glu Thr Ala Phe Val Gln Asn Ala Ser Met Glu Phe Asp 
    450                 455                 460                 

Thr Ala Thr Leu Arg Pro Thr Tyr Arg Phe Met Gln Gly Val Pro Gly 
465                 470                 475                 480 

Arg Ser Asn Ala Phe Glu Ile Ala Lys Arg Leu Gly Leu Ser Glu Val 
                485                 490                 495     

Ile Val Gly Asp Ala Ser Gln Gln Ile Asp Gln Asp Asn Asp Val Asn 
            500                 505                 510         

Arg Ile Ile Glu Gln Leu Glu Glu Gln Thr Leu Glu Ser Arg Lys Arg 
        515                 520                 525             

Leu Asp Asn Ile Arg Glu Val Glu Gln Glu Asn Leu Lys Met Asn Arg 
    530                 535                 540                 

Ala Leu Lys Lys Leu Tyr Asn Glu Leu Asn Arg Glu Lys Glu Thr Glu 
545                 550                 555                 560 

Leu Asn Lys Ala Arg Glu Gln Ala Ala Glu Ile Val Asp Met Ala Leu 
                565                 570                 575     

Ser Glu Ser Asp Gln Ile Leu Lys Asn Leu His Ser Lys Ser Gln Leu 
            580                 585                 590         

Lys Pro His Glu Ile Ile Glu Ala Lys Ala Lys Leu Lys Lys Leu Ala 
        595                 600                 605             

Pro Glu Lys Val Asp Leu Ser Lys Asn Lys Val Leu Gln Lys Ala Lys 
    610                 615                 620                 

Lys Lys Arg Ala Pro Lys Val Gly Asp Asp Ile Val Val Leu Ser Tyr 
625                 630                 635                 640 

Gly Gln Arg Gly Thr Leu Thr Ser Gln Leu Lys Asp Gly Arg Trp Glu 
                645                 650                 655     

Ala Gln Val Gly Leu Ile Lys Met Thr Leu Glu Glu Lys Glu Phe Asp 
            660                 665                 670         

Leu Val Gln Ala Gln Gln Glu Lys Pro Val Lys Lys Lys Gln Val Asn 
        675                 680                 685             

Val Val Lys Arg Thr Ser Gly Arg Gly Pro Gln Ala Arg Leu Asp Leu 
    690                 695                 700                 

Arg Gly Lys Arg Tyr Glu Glu Ala Met Asn Glu Leu Asp Thr Phe Ile 
705                 710                 715                 720 

Asp Gln Ala Leu Leu Asn Asn Met Ala Gln Val Asp Ile Ile His Gly 
                725                 730                 735     

Ile Gly Thr Gly Val Ile Arg Glu Gly Val Thr Lys Tyr Leu Gln Arg 
            740                 745                 750         

Asn Lys His Val Lys Ser Phe Gly Tyr Ala Pro Gln Asn Ala Gly Gly 
        755                 760                 765             

Ser Gly Ala Thr Ile Val Thr Phe Lys Gly 
    770                 775             

<210>   655
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   655
ttgagcagtt gcctgccttg ccccttcggt gcctttacgg tctctccaga gttccgtcca   60
tttacagtca tggaaaatca aacgattccc cacttctat                          99

<210>   656
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   656
Met Ser Ser Cys Leu Pro Cys Pro Phe Gly Ala Phe Thr Val Ser Pro 
1               5                   10                  15      

Glu Phe Arg Pro Phe Thr Val Met Glu Asn Gln Thr Ile Pro His Phe 
            20                  25                  30          

Tyr 
    

<210>   657
<211>   1320
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   657
atgttagaat tgcttaaatc aatcgatgct tttgcttggg gaccgcccct cttgatttta   60
ttggtcggaa cagggattta cctaactatt cggctaggac tcttgcaggt tttgcgtcta   120
cccaaggcct ttcagcttat ttttatccag gataagggac atggtgatgt atccagtttt   180
gcagctctgt gtacagcctt ggcatcaact gttggaacag gaaatatcat aggagttgcg   240
acggctatca aggttggtgg accaggagct ctattttgga tgtggatggc ggctttcttt   300
ggaatggcta ccaagtatgc ggaaggactc ttggccatca aataccgcac caaggacgac   360
catggtgcag tagcgggagg tcccatgcat tatatccttc tagggatggg agaaaagtgg   420
cgaccacttg ctgttttgtt tgcagtagca ggagtattgg ttgctctctt gggaatcgga   480
accttcaccc aagtcaactc gattgcagaa tctatccaaa atacaacgac gatttcgcca   540
gccatcacag ctctcgtctt gtctgtcttt gtagcgattg cagtctttgg tggactcaag   600
tctatttcta aggtttcaac tactgttgtt ccttttatgg ccatcattta tatcttagga   660
actcttacag ttattttctt taatatcgga aaaatccctg gcacaatcgc tttagtcttt   720
acctcagctt ttagtcccct tgctgcggta ggtggatttg ctggtgctag cgttcggatg   780
gctattcaaa atggtgtggc gcgtggtgtg ttctcaaacg aatctggtct gggttctgct   840
cctattgcag ctgcagctgc caagacaaat gaaccagtag agcaaggttt gatttccatg   900
acaggaacct ttattgatac cctcatcatt tgtactctaa ctggtttgac catcttggta   960
actggagttt ggagcggtga cttgaatggg gttgccttga ctcagtcagc tttctcaaca   1020
aacttttcac actttgggcc tgctctcttg accatcttcc ttgtactttt tgcctttaca   1080
acgattctag gttggaacta ttacggagaa cgctgttttg agttcctctt tggggttcgc   1140
tttatctggc tctaccgtgt ggtttttgtg ctcatggtct tgttaggagg atttatcgag   1200
ttggatatgg tctggattat cgcagatatc gttaacgcct tgatggctct gccaaacttg   1260
attgccctct tggtcttgtc gccagtcgtt attgctgaaa ctaaaaagta ttttgacaaa   1320

<210>   658
<211>   440
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sodium:alanine symporter family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902413 (0.E+01)

<400>   658
Met Leu Glu Leu Leu Lys Ser Ile Asp Ala Phe Ala Trp Gly Pro Pro 
1               5                   10                  15      

Leu Leu Ile Leu Leu Val Gly Thr Gly Ile Tyr Leu Thr Ile Arg Leu 
            20                  25                  30          

Gly Leu Leu Gln Val Leu Arg Leu Pro Lys Ala Phe Gln Leu Ile Phe 
        35                  40                  45              

Ile Gln Asp Lys Gly His Gly Asp Val Ser Ser Phe Ala Ala Leu Cys 
    50                  55                  60                  

Thr Ala Leu Ala Ser Thr Val Gly Thr Gly Asn Ile Ile Gly Val Ala 
65                  70                  75                  80  

Thr Ala Ile Lys Val Gly Gly Pro Gly Ala Leu Phe Trp Met Trp Met 
                85                  90                  95      

Ala Ala Phe Phe Gly Met Ala Thr Lys Tyr Ala Glu Gly Leu Leu Ala 
            100                 105                 110         

Ile Lys Tyr Arg Thr Lys Asp Asp His Gly Ala Val Ala Gly Gly Pro 
        115                 120                 125             

Met His Tyr Ile Leu Leu Gly Met Gly Glu Lys Trp Arg Pro Leu Ala 
    130                 135                 140                 

Val Leu Phe Ala Val Ala Gly Val Leu Val Ala Leu Leu Gly Ile Gly 
145                 150                 155                 160 

Thr Phe Thr Gln Val Asn Ser Ile Ala Glu Ser Ile Gln Asn Thr Thr 
                165                 170                 175     

Thr Ile Ser Pro Ala Ile Thr Ala Leu Val Leu Ser Val Phe Val Ala 
            180                 185                 190         

Ile Ala Val Phe Gly Gly Leu Lys Ser Ile Ser Lys Val Ser Thr Thr 
        195                 200                 205             

Val Val Pro Phe Met Ala Ile Ile Tyr Ile Leu Gly Thr Leu Thr Val 
    210                 215                 220                 

Ile Phe Phe Asn Ile Gly Lys Ile Pro Gly Thr Ile Ala Leu Val Phe 
225                 230                 235                 240 

Thr Ser Ala Phe Ser Pro Leu Ala Ala Val Gly Gly Phe Ala Gly Ala 
                245                 250                 255     


Ser Val Arg Met Ala Ile Gln Asn Gly Val Ala Arg Gly Val Phe Ser 
            260                 265                 270         

Asn Glu Ser Gly Leu Gly Ser Ala Pro Ile Ala Ala Ala Ala Ala Lys 
        275                 280                 285             

Thr Asn Glu Pro Val Glu Gln Gly Leu Ile Ser Met Thr Gly Thr Phe 
    290                 295                 300                 

Ile Asp Thr Leu Ile Ile Cys Thr Leu Thr Gly Leu Thr Ile Leu Val 
305                 310                 315                 320 

Thr Gly Val Trp Ser Gly Asp Leu Asn Gly Val Ala Leu Thr Gln Ser 
                325                 330                 335     

Ala Phe Ser Thr Asn Phe Ser His Phe Gly Pro Ala Leu Leu Thr Ile 
            340                 345                 350         

Phe Leu Val Leu Phe Ala Phe Thr Thr Ile Leu Gly Trp Asn Tyr Tyr 
        355                 360                 365             

Gly Glu Arg Cys Phe Glu Phe Leu Phe Gly Val Arg Phe Ile Trp Leu 
    370                 375                 380                 

Tyr Arg Val Val Phe Val Leu Met Val Leu Leu Gly Gly Phe Ile Glu 
385                 390                 395                 400 

Leu Asp Met Val Trp Ile Ile Ala Asp Ile Val Asn Ala Leu Met Ala 
                405                 410                 415     

Leu Pro Asn Leu Ile Ala Leu Leu Val Leu Ser Pro Val Val Ile Ala 
            420                 425                 430         

Glu Thr Lys Lys Tyr Phe Asp Lys 
        435                 440 

<210>   659
<211>   546
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   659
atgacaacat ttactatcca tacagtagag tcagcaccag cagaagtgaa agaaattctt   60
gaaacagtag aaaaagacaa caatggctat attcccaacc taatcggtct cttggccaat   120
gccccgactg ttttagaagc ctaccaaatt gtctcatcta tccaccgtcg caacagcctg   180
acacccgttg agcgtgaagt ggtgcaaatc acggcagccg tgaccaatgg ttgtgccttc   240
tgtgtcgcag gtcacacagc cttttccatc aaacaaatcc agatgaatga tgacttgatt   300
caagctcttc gcaatcgtac tccaattgaa acagatccta aattggatac cctagctaag   360
tttaccttgg cagttatcaa taccaagggt cgtgtaggag atgaagcctt gtctgagttt   420
ttagaagctg gctacactca acaaaatgcc ttggatgtgg tttttggtgt cagcctagca   480
atcctctgta actatgccaa caacttagct aatacaccaa ttaatccaga attgcaacct   540
tatgcc                                                              546

<210>   660
<211>   182
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (Macrophage infectivity)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902414 (e-101)

<400>   660
Met Thr Thr Phe Thr Ile His Thr Val Glu Ser Ala Pro Ala Glu Val 
1               5                   10                  15      

Lys Glu Ile Leu Glu Thr Val Glu Lys Asp Asn Asn Gly Tyr Ile Pro 
            20                  25                  30          

Asn Leu Ile Gly Leu Leu Ala Asn Ala Pro Thr Val Leu Glu Ala Tyr 
        35                  40                  45              

Gln Ile Val Ser Ser Ile His Arg Arg Asn Ser Leu Thr Pro Val Glu 
    50                  55                  60                  

Arg Glu Val Val Gln Ile Thr Ala Ala Val Thr Asn Gly Cys Ala Phe 
65                  70                  75                  80  

Cys Val Ala Gly His Thr Ala Phe Ser Ile Lys Gln Ile Gln Met Asn 
                85                  90                  95      

Asp Asp Leu Ile Gln Ala Leu Arg Asn Arg Thr Pro Ile Glu Thr Asp 
            100                 105                 110         

Pro Lys Leu Asp Thr Leu Ala Lys Phe Thr Leu Ala Val Ile Asn Thr 
        115                 120                 125             

Lys Gly Arg Val Gly Asp Glu Ala Leu Ser Glu Phe Leu Glu Ala Gly 
    130                 135                 140                 

Tyr Thr Gln Gln Asn Ala Leu Asp Val Val Phe Gly Val Ser Leu Ala 
145                 150                 155                 160 


Ile Leu Cys Asn Tyr Ala Asn Asn Leu Ala Asn Thr Pro Ile Asn Pro 
                165                 170                 175     

Glu Leu Gln Pro Tyr Ala 
            180         

<210>   661
<211>   909
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   661
ttggaggtta ggatgaaaaa actcccctta gtattttcag gttgtttgct aggtttggca   60
ggagctggaa atcttatttt agatacgttg ccggttctat cccatctttt tagtctgatt   120
ggtttggttt tatggattta ctttctaatt ctgcatctct ttaattggaa agaaaccaag   180
caagaattga ccaagccccc tcttttgtca ggaatggcaa cctttcctat ggctgggatg   240
attttatcga cctatgtctt tcgcgtattc tcttatcttc ctttggtagc acaagggatt   300
tggtggtttt catttctctt ggatttgacc ttgattgctg gttttaccat caagtttgct   360
tgtccagggc ggagggttca tgccactcca agctggacgg ttctctatgt ggggatagca   420
gtggctgcct tgacctatcc tctggtaggt attatcgaaa ttgcctatgc gaccttgagt   480
tttggttttc tcttgacctt ctatctctat ccccttattt atagcgattt aaagaaacat   540
ccactcccac tagccttgct tggacaagaa ggaatctact gtgctccttt ctctctactc   600
ttggcttctc tagttcgagt aggaggaacc agcctgccga cttgggtctt gattgtcatg   660
attttggctt ctcaatcctt ctttttcttt gttttaactc gtctgcccaa cattttaaaa   720
caaggttttc aaccagcctt ctcagccctc accttcccaa ccattatcac agcgacctcg   780
ctcaagatgg ctcagggaat tttgaaactt ccatttctgg attacctggt attggctgaa   840
accattatat gcctaactat tttattcttt gtactaggtg cttatctgat ttggttacga   900
aaaaaggtc                                                           909

<210>   662
<211>   303
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   exfoliative toxin, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902415 (e-170)

<400>   662
Met Glu Val Arg Met Lys Lys Leu Pro Leu Val Phe Ser Gly Cys Leu 
1               5                   10                  15      

Leu Gly Leu Ala Gly Ala Gly Asn Leu Ile Leu Asp Thr Leu Pro Val 
            20                  25                  30          

Leu Ser His Leu Phe Ser Leu Ile Gly Leu Val Leu Trp Ile Tyr Phe 
        35                  40                  45              

Leu Ile Leu His Leu Phe Asn Trp Lys Glu Thr Lys Gln Glu Leu Thr 
    50                  55                  60                  

Lys Pro Pro Leu Leu Ser Gly Met Ala Thr Phe Pro Met Ala Gly Met 
65                  70                  75                  80  

Ile Leu Ser Thr Tyr Val Phe Arg Val Phe Ser Tyr Leu Pro Leu Val 
                85                  90                  95      

Ala Gln Gly Ile Trp Trp Phe Ser Phe Leu Leu Asp Leu Thr Leu Ile 
            100                 105                 110         

Ala Gly Phe Thr Ile Lys Phe Ala Cys Pro Gly Arg Arg Val His Ala 
        115                 120                 125             

Thr Pro Ser Trp Thr Val Leu Tyr Val Gly Ile Ala Val Ala Ala Leu 
    130                 135                 140                 

Thr Tyr Pro Leu Val Gly Ile Ile Glu Ile Ala Tyr Ala Thr Leu Ser 
145                 150                 155                 160 

Phe Gly Phe Leu Leu Thr Phe Tyr Leu Tyr Pro Leu Ile Tyr Ser Asp 
                165                 170                 175     

Leu Lys Lys His Pro Leu Pro Leu Ala Leu Leu Gly Gln Glu Gly Ile 
            180                 185                 190         

Tyr Cys Ala Pro Phe Ser Leu Leu Leu Ala Ser Leu Val Arg Val Gly 
        195                 200                 205             

Gly Thr Ser Leu Pro Thr Trp Val Leu Ile Val Met Ile Leu Ala Ser 
    210                 215                 220                 

Gln Ser Phe Phe Phe Phe Val Leu Thr Arg Leu Pro Asn Ile Leu Lys 
225                 230                 235                 240 

Gln Gly Phe Gln Pro Ala Phe Ser Ala Leu Thr Phe Pro Thr Ile Ile 
                245                 250                 255     

Thr Ala Thr Ser Leu Lys Met Ala Gln Gly Ile Leu Lys Leu Pro Phe 
            260                 265                 270         

Leu Asp Tyr Leu Val Leu Ala Glu Thr Ile Ile Cys Leu Thr Ile Leu 
        275                 280                 285             

Phe Phe Val Leu Gly Ala Tyr Leu Ile Trp Leu Arg Lys Lys Val 
    290                 295                 300             

<210>   663
<211>   1272
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   663
atgttagata tcaaacgtat tcgtacagat tttgaagctg tcgcagaaaa attagctaca   60
cgtggtgtag atgctgctgt cttgaatgaa atgaaagaaa tcgatgctaa acgtcgtaac   120
atcttggtca aggttgaaac tctcaaagca gaacgtaaca cagtttctgc tgagattgcc   180
caagctaagc gcaacaagga aaatacagat gacaagattg ctgccatgca aaatctatct   240
gctgaggtta aagccttgga tgctgaattg gcagaaatcg atgctaaatt gacagaattt   300
acaacgactc ttccaaatat cccagctgac agcgttcctg ttggggctga cgaagacgac   360
aatgtggaag ttcgccgttg gggtactcca cgcgagtttg acttcgaacc taaagctcac   420
tgggatctcg gtgaagacct tggtatcctt gactgggaac gcggtggtaa ggtaacaggc   480
gctcgcttcc tcttctataa aggcctcggt gctcgtttgg aacgtgctat ctacaacttt   540

atgttggatg aacatggaaa agaaggctat actgaagtca tcacacctta catagtcaac   600
catgattcta tgtttggtac tggtcagtat ccaaaattta aggaagatac ttttgaactc   660
agcgatacca actttgtctt gattccaact gctgaagttc ctctgacaaa ctactaccgt   720
gatgaaatct tagacggcaa agatcttcca atctacttca ctgccatgag tccgtcattc   780
cgttctgagg ctggttctgc cggtcgtgat acgcgtggct tgatccgttt gcaccaattc   840
cacaaggttg aaatggtcaa atttgccaaa ccagaagaat cttacgaaga attggaaaaa   900
atgacagcca acgctgaaaa cattcttcaa aaactcaacc ttccataccg tgtcgttgct   960
ctctctactg gagatatggg cttctcagct gcgaagactt acgacttgga agtgtggatt   1020
ccagcacaaa acaattaccg tgaaatctca agctgttcaa acacagaaga tttccaagcc   1080
cgtcgtgccc aaatccgtta ccgtgatgaa gcagatggca aggtgaaact ccttcatacc   1140
ttgaacggtt ctggacttgc agttggacgt acagtggctg caattcttga aaattaccaa   1200
aatgaagatg gttctgtgac catcccagaa gcacttcgtc catacatggg tggagctgaa   1260
gtcatcaaac ca                                                       1272

<210>   664
<211>   424
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   seryl-tRNA synthetase (serS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902416 (0.E+01)

<400>   664
Met Leu Asp Ile Lys Arg Ile Arg Thr Asp Phe Glu Ala Val Ala Glu 
1               5                   10                  15      

Lys Leu Ala Thr Arg Gly Val Asp Ala Ala Val Leu Asn Glu Met Lys 
            20                  25                  30          

Glu Ile Asp Ala Lys Arg Arg Asn Ile Leu Val Lys Val Glu Thr Leu 
        35                  40                  45              

Lys Ala Glu Arg Asn Thr Val Ser Ala Glu Ile Ala Gln Ala Lys Arg 
    50                  55                  60                  

Asn Lys Glu Asn Thr Asp Asp Lys Ile Ala Ala Met Gln Asn Leu Ser 
65                  70                  75                  80  

Ala Glu Val Lys Ala Leu Asp Ala Glu Leu Ala Glu Ile Asp Ala Lys 
                85                  90                  95      

Leu Thr Glu Phe Thr Thr Thr Leu Pro Asn Ile Pro Ala Asp Ser Val 
            100                 105                 110         

Pro Val Gly Ala Asp Glu Asp Asp Asn Val Glu Val Arg Arg Trp Gly 
        115                 120                 125             

Thr Pro Arg Glu Phe Asp Phe Glu Pro Lys Ala His Trp Asp Leu Gly 
    130                 135                 140                 

Glu Asp Leu Gly Ile Leu Asp Trp Glu Arg Gly Gly Lys Val Thr Gly 
145                 150                 155                 160 

Ala Arg Phe Leu Phe Tyr Lys Gly Leu Gly Ala Arg Leu Glu Arg Ala 
                165                 170                 175     

Ile Tyr Asn Phe Met Leu Asp Glu His Gly Lys Glu Gly Tyr Thr Glu 
            180                 185                 190         

Val Ile Thr Pro Tyr Ile Val Asn His Asp Ser Met Phe Gly Thr Gly 
        195                 200                 205             

Gln Tyr Pro Lys Phe Lys Glu Asp Thr Phe Glu Leu Ser Asp Thr Asn 
    210                 215                 220                 

Phe Val Leu Ile Pro Thr Ala Glu Val Pro Leu Thr Asn Tyr Tyr Arg 
225                 230                 235                 240 

Asp Glu Ile Leu Asp Gly Lys Asp Leu Pro Ile Tyr Phe Thr Ala Met 
                245                 250                 255     

Ser Pro Ser Phe Arg Ser Glu Ala Gly Ser Ala Gly Arg Asp Thr Arg 
            260                 265                 270         

Gly Leu Ile Arg Leu His Gln Phe His Lys Val Glu Met Val Lys Phe 
        275                 280                 285             

Ala Lys Pro Glu Glu Ser Tyr Glu Glu Leu Glu Lys Met Thr Ala Asn 
    290                 295                 300                 

Ala Glu Asn Ile Leu Gln Lys Leu Asn Leu Pro Tyr Arg Val Val Ala 
305                 310                 315                 320 

Leu Ser Thr Gly Asp Met Gly Phe Ser Ala Ala Lys Thr Tyr Asp Leu 
                325                 330                 335     

Glu Val Trp Ile Pro Ala Gln Asn Asn Tyr Arg Glu Ile Ser Ser Cys 
            340                 345                 350         

Ser Asn Thr Glu Asp Phe Gln Ala Arg Arg Ala Gln Ile Arg Tyr Arg 
        355                 360                 365             

Asp Glu Ala Asp Gly Lys Val Lys Leu Leu His Thr Leu Asn Gly Ser 
    370                 375                 380                 

Gly Leu Ala Val Gly Arg Thr Val Ala Ala Ile Leu Glu Asn Tyr Gln 
385                 390                 395                 400 

Asn Glu Asp Gly Ser Val Thr Ile Pro Glu Ala Leu Arg Pro Tyr Met 
                405                 410                 415     

Gly Gly Ala Glu Val Ile Lys Pro 
            420                 

<210>   665
<211>   369
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   665
atggcccaat cacttaacaa aacagtactc ctcagtacga caggcacttc ctacctctct   60
atcgctggga aagttgggaa attccttgtc ggagatcagg ctttggaatt ttacccagat   120
gtcaatgtcg aacaatttat ccagattcct tggagccata tcaatcagat tggagccaat   180
gtcactggac gcaaaatcag ccgccacttc gaagtcttta cagacaaagg aaaattcctc   240
tttgcttcaa aagactcagg tgccattctc aaaattgcac gcgaaaaact aggcaatgac   300
aaggtcgtca aacttccgac cctgattcag acaattagcc aaaaatttaa aaatctattt   360
gcaaaaaag                                                           369

<210>   666
<211>   123
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902417 (4.E-66)

<400>   666
Met Ala Gln Ser Leu Asn Lys Thr Val Leu Leu Ser Thr Thr Gly Thr 
1               5                   10                  15      

Ser Tyr Leu Ser Ile Ala Gly Lys Val Gly Lys Phe Leu Val Gly Asp 
            20                  25                  30          

Gln Ala Leu Glu Phe Tyr Pro Asp Val Asn Val Glu Gln Phe Ile Gln 
        35                  40                  45              

Ile Pro Trp Ser His Ile Asn Gln Ile Gly Ala Asn Val Thr Gly Arg 
    50                  55                  60                  

Lys Ile Ser Arg His Phe Glu Val Phe Thr Asp Lys Gly Lys Phe Leu 
65                  70                  75                  80  

Phe Ala Ser Lys Asp Ser Gly Ala Ile Leu Lys Ile Ala Arg Glu Lys 
                85                  90                  95      

Leu Gly Asn Asp Lys Val Val Lys Leu Pro Thr Leu Ile Gln Thr Ile 
            100                 105                 110         

Ser Gln Lys Phe Lys Asn Leu Phe Ala Lys Lys 
        115                 120             

<210>   667
<211>   1362
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   667
atgaaagttg ttaaatttgg aggtagttct cttgcctctg ctagtcaatt agaaaaagtt   60
ttaaacatcg tcaaaagcga ttcagagcgt cgttttgtag tcgtttctgc gcctggtaaa   120
cgcaatgctg aagatactaa ggttacggat gccctgatta aatactaccg cgactatgtt   180
gcgggtaacg atattagcaa gaaccaaagc tggattatcg accgctatgc tgctatggtt   240
agtgaattgg gactaaaacc agctgtgcta gaaaaaattt ctaaaagcat tcacgccttg   300
gccactcttc ctattgaaga aaatgaattt ctctacgata ctttcctagc agccggtgaa   360
aataacaatg ccaaattgat tgctgcctac tttaaccaaa atggtatcga tgcacgctat   420
atgcacccta gagaagctgg gattgtggtc acaagtgaac ctggtcacgc tcgcatcatt   480
ccatcaagtt atgacaagat tgaagaattg acaaacacca atgaagtcct tgtcattcct   540
ggtttctttg gtgtcactaa ggaaaatcaa atctgtactt tctcacgtgg aggttctgat   600
attacaggtt ctatcattgc tgctggtgtc aaagctgacc tctatgaaaa ctttacggac   660
gttgatggta tctttgcagc ccaccctggt attatccacc aaccacactc gattcctgag   720
ttgacctacc gtgaaatgcg cgagttggcc tatgcaggct tctcagtcct tcatgacgag   780
gctcttcttc ctgcctaccg tggaaaaatt cctctggtta tcaagaatac caacaaccct   840
gaccatccag gtactcgtat cgttctaaaa cacagtaatg atgaatttcc agttgtggga   900
attgctggtg actcaggctt tgtcagcatt aacatgtcga aatacctcat gaaccgtgag   960
gttggatttg gccgcaaggt tctgcaaatc ctggaagaac ttaacatcgg ttgggaacat   1020
atgccaacag gtatcgacga tctttctatc attctccgtt ctcgccaact aactcccatc   1080
aaggaagaag aaatcctgcg tcagttggtt caaaaggcta aagtagatca tgcagaaatc   1140
gaacacgacc tttctatcat tatgattgtt ggtgaaaaaa tgaagagcca tatcggagtg   1200
actgctactg cgacacgcgc tctatctgaa aacaaaatca acatccagat gatgtctcaa   1260
ggttctagtg aagtttctat tatgtttgtt gtcaataaag accaagagaa agcagcaatt   1320
aaagccctct acaatgcctt ttttggagaa agtaaggaag ac                      1362

<210>   668
<211>   454
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aspartate kinase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902418 (0.E+01)

<400>   668
Met Lys Val Val Lys Phe Gly Gly Ser Ser Leu Ala Ser Ala Ser Gln 
1               5                   10                  15      


Leu Glu Lys Val Leu Asn Ile Val Lys Ser Asp Ser Glu Arg Arg Phe 
            20                  25                  30          

Val Val Val Ser Ala Pro Gly Lys Arg Asn Ala Glu Asp Thr Lys Val 
        35                  40                  45              

Thr Asp Ala Leu Ile Lys Tyr Tyr Arg Asp Tyr Val Ala Gly Asn Asp 
    50                  55                  60                  

Ile Ser Lys Asn Gln Ser Trp Ile Ile Asp Arg Tyr Ala Ala Met Val 
65                  70                  75                  80  

Ser Glu Leu Gly Leu Lys Pro Ala Val Leu Glu Lys Ile Ser Lys Ser 
                85                  90                  95      

Ile His Ala Leu Ala Thr Leu Pro Ile Glu Glu Asn Glu Phe Leu Tyr 
            100                 105                 110         

Asp Thr Phe Leu Ala Ala Gly Glu Asn Asn Asn Ala Lys Leu Ile Ala 
        115                 120                 125             

Ala Tyr Phe Asn Gln Asn Gly Ile Asp Ala Arg Tyr Met His Pro Arg 
    130                 135                 140                 

Glu Ala Gly Ile Val Val Thr Ser Glu Pro Gly His Ala Arg Ile Ile 
145                 150                 155                 160 

Pro Ser Ser Tyr Asp Lys Ile Glu Glu Leu Thr Asn Thr Asn Glu Val 
                165                 170                 175     

Leu Val Ile Pro Gly Phe Phe Gly Val Thr Lys Glu Asn Gln Ile Cys 
            180                 185                 190         

Thr Phe Ser Arg Gly Gly Ser Asp Ile Thr Gly Ser Ile Ile Ala Ala 
        195                 200                 205             

Gly Val Lys Ala Asp Leu Tyr Glu Asn Phe Thr Asp Val Asp Gly Ile 
    210                 215                 220                 

Phe Ala Ala His Pro Gly Ile Ile His Gln Pro His Ser Ile Pro Glu 
225                 230                 235                 240 

Leu Thr Tyr Arg Glu Met Arg Glu Leu Ala Tyr Ala Gly Phe Ser Val 
                245                 250                 255     

Leu His Asp Glu Ala Leu Leu Pro Ala Tyr Arg Gly Lys Ile Pro Leu 
            260                 265                 270         

Val Ile Lys Asn Thr Asn Asn Pro Asp His Pro Gly Thr Arg Ile Val 
        275                 280                 285             

Leu Lys His Ser Asn Asp Glu Phe Pro Val Val Gly Ile Ala Gly Asp 
    290                 295                 300                 

Ser Gly Phe Val Ser Ile Asn Met Ser Lys Tyr Leu Met Asn Arg Glu 
305                 310                 315                 320 

Val Gly Phe Gly Arg Lys Val Leu Gln Ile Leu Glu Glu Leu Asn Ile 
                325                 330                 335     

Gly Trp Glu His Met Pro Thr Gly Ile Asp Asp Leu Ser Ile Ile Leu 
            340                 345                 350         

Arg Ser Arg Gln Leu Thr Pro Ile Lys Glu Glu Glu Ile Leu Arg Gln 
        355                 360                 365             

Leu Val Gln Lys Ala Lys Val Asp His Ala Glu Ile Glu His Asp Leu 
    370                 375                 380                 

Ser Ile Ile Met Ile Val Gly Glu Lys Met Lys Ser His Ile Gly Val 
385                 390                 395                 400 

Thr Ala Thr Ala Thr Arg Ala Leu Ser Glu Asn Lys Ile Asn Ile Gln 
                405                 410                 415     

Met Met Ser Gln Gly Ser Ser Glu Val Ser Ile Met Phe Val Val Asn 
            420                 425                 430         

Lys Asp Gln Glu Lys Ala Ala Ile Lys Ala Leu Tyr Asn Ala Phe Phe 
        435                 440                 445             

Gly Glu Ser Lys Glu Asp 
    450                 

<210>   669
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   669
ttgagtgtta aattatttca ctgtcaaagt atatcttttt taggagcaga aagcaagaaa   60
aaatcgactg aaagtgtctc agccgataag aaaggctcgc tt                      102

<210>   670
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   670
Met Ser Val Lys Leu Phe His Cys Gln Ser Ile Ser Phe Leu Gly Ala 
1               5                   10                  15      

Glu Ser Lys Lys Lys Ser Thr Glu Ser Val Ser Ala Asp Lys Lys Gly 
            20                  25                  30          

Ser Leu 
        

<210>   671
<211>   165
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   671
ttgataaata atgtgttcca tcagggctcc tttttatttt ataagcagtt tatactcttc   60
gaaaatctct ttaaaccgcg tcagcttcca tctgcaacct caaaacagta ttttgagctg   120
acttcgtcta gcttcttagt ttgctctttg attttcattg agtgt                   165

<210>   672
<211>   55
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   672
Met Ile Asn Asn Val Phe His Gln Gly Ser Phe Leu Phe Tyr Lys Gln 
1               5                   10                  15      

Phe Ile Leu Phe Glu Asn Leu Phe Lys Pro Arg Gln Leu Pro Ser Ala 
            20                  25                  30          

Thr Ser Lys Gln Tyr Phe Glu Leu Thr Ser Ser Ser Phe Leu Val Cys 
        35                  40                  45              

Ser Leu Ile Phe Ile Glu Cys 
    50                  55  

<210>   673
<211>   783
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   673
atggaacaca ttatttatca acttgaagag gacttggcaa tccttacctt gaaccgtcct   60
gaggtcgcaa atggttttca tattcccatg tgtgaggaga ttttagaagc tctgactttg   120
gcagaagaaa atccagctgt gcattttatc ttaatcaatg ccaatggaaa ggtcttctca   180
gttgggggag atttggtaga gatgaagcgg gcagtggatg aggatgatat tccatcattg   240
acaaaaatcg cagagttggt caatacgatt tcttataaaa tcaagcaaat agccaaacct   300
gttttaatgg aagttgacgg tgctgttgca ggtgccgcag cgaatatggc tgttgcggca   360
gatttctgtt tggcgacgga taaggctaag tttatccaag cctttgttgg tgttggtttg   420
gctccagatg caggggggat tcatctcttg agccgcagta tcggtgtgac gcgtgctgct   480
caattagcta tgacaggaga ggctttaacg gcagaaaaag ccctagaatg ggggttggtt   540
taccgcgttt ctgaagctga aaaacttgaa aagacgagag aacagcttct taaaaaatta   600
agacgtgctt caagtaattc ctatgctgcc attaagaagt tggtttggga gagccaattt   660
aaagactggc agggttacgc tactttagaa ctgaacctac agaaatcctt agctcaaaca   720
gaggatttca aagaaggagt gcgagctcat tcggagagaa gaagacctaa atttacagga   780
aaa                                                                 783

<210>   674
<211>   261
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   enoyl-CoA hydratase/isomerase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902419 (e-144)

<400>   674
Met Glu His Ile Ile Tyr Gln Leu Glu Glu Asp Leu Ala Ile Leu Thr 
1               5                   10                  15      

Leu Asn Arg Pro Glu Val Ala Asn Gly Phe His Ile Pro Met Cys Glu 
            20                  25                  30          

Glu Ile Leu Glu Ala Leu Thr Leu Ala Glu Glu Asn Pro Ala Val His 
        35                  40                  45              

Phe Ile Leu Ile Asn Ala Asn Gly Lys Val Phe Ser Val Gly Gly Asp 
    50                  55                  60                  

Leu Val Glu Met Lys Arg Ala Val Asp Glu Asp Asp Ile Pro Ser Leu 
65                  70                  75                  80  

Thr Lys Ile Ala Glu Leu Val Asn Thr Ile Ser Tyr Lys Ile Lys Gln 
                85                  90                  95      

Ile Ala Lys Pro Val Leu Met Glu Val Asp Gly Ala Val Ala Gly Ala 
            100                 105                 110         

Ala Ala Asn Met Ala Val Ala Ala Asp Phe Cys Leu Ala Thr Asp Lys 
        115                 120                 125             

Ala Lys Phe Ile Gln Ala Phe Val Gly Val Gly Leu Ala Pro Asp Ala 
    130                 135                 140                 


Gly Gly Ile His Leu Leu Ser Arg Ser Ile Gly Val Thr Arg Ala Ala 
145                 150                 155                 160 

Gln Leu Ala Met Thr Gly Glu Ala Leu Thr Ala Glu Lys Ala Leu Glu 
                165                 170                 175     

Trp Gly Leu Val Tyr Arg Val Ser Glu Ala Glu Lys Leu Glu Lys Thr 
            180                 185                 190         

Arg Glu Gln Leu Leu Lys Lys Leu Arg Arg Ala Ser Ser Asn Ser Tyr 
        195                 200                 205             

Ala Ala Ile Lys Lys Leu Val Trp Glu Ser Gln Phe Lys Asp Trp Gln 
    210                 215                 220                 

Gly Tyr Ala Thr Leu Glu Leu Asn Leu Gln Lys Ser Leu Ala Gln Thr 
225                 230                 235                 240 

Glu Asp Phe Lys Glu Gly Val Arg Ala His Ser Glu Arg Arg Arg Pro 
                245                 250                 255     

Lys Phe Thr Gly Lys 
            260     

<210>   675
<211>   432
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   675
atggactacc aacgaatcaa tgaatattta acatctatat ttaacaatgt ccttgtaatt   60
gaggaagtga acttgagagg tagtcgtttt aaggatatct ccatcaaaga aatgcatacg   120
attgatgtca tcggtaaggc tccagacgtg actccaagtc aagtgtcaaa agagttgatg   180
gtaactcttg gaactgttac gacaagtttg aacaatttag agcgtaaggg ctacattgag   240
cgagttcggt cagaacagga tcgtcgtgtg gtgcatctgc atttgacaaa gaagggtcgc   300
ttgattcata gactgcataa acgcttccac aaggccatgg tagaaaaaat tattgatggc   360
atgagcgagg aagaaattgc tgtcatgggt aaaggtttga ctaatcttta ccaatttttg   420
gaggatttga aa                                                       432

<210>   676
<211>   144
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, MarR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902420 (2.E-78)

<400>   676
Met Asp Tyr Gln Arg Ile Asn Glu Tyr Leu Thr Ser Ile Phe Asn Asn 
1               5                   10                  15      

Val Leu Val Ile Glu Glu Val Asn Leu Arg Gly Ser Arg Phe Lys Asp 
            20                  25                  30          

Ile Ser Ile Lys Glu Met His Thr Ile Asp Val Ile Gly Lys Ala Pro 
        35                  40                  45              

Asp Val Thr Pro Ser Gln Val Ser Lys Glu Leu Met Val Thr Leu Gly 
    50                  55                  60                  

Thr Val Thr Thr Ser Leu Asn Asn Leu Glu Arg Lys Gly Tyr Ile Glu 
65                  70                  75                  80  

Arg Val Arg Ser Glu Gln Asp Arg Arg Val Val His Leu His Leu Thr 
                85                  90                  95      

Lys Lys Gly Arg Leu Ile His Arg Leu His Lys Arg Phe His Lys Ala 
            100                 105                 110         

Met Val Glu Lys Ile Ile Asp Gly Met Ser Glu Glu Glu Ile Ala Val 
        115                 120                 125             

Met Gly Lys Gly Leu Thr Asn Leu Tyr Gln Phe Leu Glu Asp Leu Lys 
    130                 135                 140                 


<210>   677
<211>   972
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   677
atggcttttg caaaaataag tcaggttgct cattatgtgc cagagcaagt ggttacaaat   60
cacgacttgg ctcagattat ggataccaat gatgagtgga tttcaagtcg aacgggaata   120
cgacaaaggc atatttcaag aacagaatct accagtgatt tggctacaga ggttgctaag   180
aaactgatgg caaaagctgg aataacagga gaagaactgg attttatcat cctagctacc   240
attactccag attcgatgat gccctctaca gctgctcgtg ttcaagctaa tattggtgct   300
aataaagcct ttgcttttga cttaaccgcg gcttgcagtg gatttgtatt tgctctttca   360
actgctgaaa agtttatcgc ttctggtcgc tttcaaaaag gcttggtgat tggtagtgaa   420
accctctcta aggcagtcga ttggtcggat cgatcaacag ctgtgttgtt tggagatggt   480
gctggtggtg tcttgttaga agctagcgag caagagcatt tcttagctga gagtctcaat   540
agcgatggaa gtcgcagcga gtgtttaact tatgggcatt caggtttaca ttctccattt   600
tcagatcaag aaagtgcaga ttcgtttttg aagatggatg gacgcacagt ctttgatttt   660
gccattcgag atgtagccaa gtctatcaag cagactattg atgaatctcc tatagaggtg   720
acagacttgg attatctgct acttcatcaa gccaatgacc gtattttgga taagatggct   780
agaaaaattg gtgttgaccg agccaaactt ccagccaata tgatggaata tggcaatacc   840
agtgcagcca gtatcccgat tttactttca gagtgtgtag aacaaggtct catcccttta   900
gatggtagcc agactgttct tctatcaggc ttcggtggag gcttgacctg gggcacgctc   960
attcttacaa tt                                                       972

<210>   678
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-oxoacyl-(acyl-carrier-protein) synthase III (fabH)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902421 (0.E+01)

<400>   678
Met Ala Phe Ala Lys Ile Ser Gln Val Ala His Tyr Val Pro Glu Gln 
1               5                   10                  15      

Val Val Thr Asn His Asp Leu Ala Gln Ile Met Asp Thr Asn Asp Glu 
            20                  25                  30          

Trp Ile Ser Ser Arg Thr Gly Ile Arg Gln Arg His Ile Ser Arg Thr 
        35                  40                  45              

Glu Ser Thr Ser Asp Leu Ala Thr Glu Val Ala Lys Lys Leu Met Ala 
    50                  55                  60                  

Lys Ala Gly Ile Thr Gly Glu Glu Leu Asp Phe Ile Ile Leu Ala Thr 
65                  70                  75                  80  

Ile Thr Pro Asp Ser Met Met Pro Ser Thr Ala Ala Arg Val Gln Ala 
                85                  90                  95      

Asn Ile Gly Ala Asn Lys Ala Phe Ala Phe Asp Leu Thr Ala Ala Cys 
            100                 105                 110         

Ser Gly Phe Val Phe Ala Leu Ser Thr Ala Glu Lys Phe Ile Ala Ser 
        115                 120                 125             

Gly Arg Phe Gln Lys Gly Leu Val Ile Gly Ser Glu Thr Leu Ser Lys 
    130                 135                 140                 

Ala Val Asp Trp Ser Asp Arg Ser Thr Ala Val Leu Phe Gly Asp Gly 
145                 150                 155                 160 

Ala Gly Gly Val Leu Leu Glu Ala Ser Glu Gln Glu His Phe Leu Ala 
                165                 170                 175     

Glu Ser Leu Asn Ser Asp Gly Ser Arg Ser Glu Cys Leu Thr Tyr Gly 
            180                 185                 190         

His Ser Gly Leu His Ser Pro Phe Ser Asp Gln Glu Ser Ala Asp Ser 
        195                 200                 205             

Phe Leu Lys Met Asp Gly Arg Thr Val Phe Asp Phe Ala Ile Arg Asp 
    210                 215                 220                 

Val Ala Lys Ser Ile Lys Gln Thr Ile Asp Glu Ser Pro Ile Glu Val 
225                 230                 235                 240 

Thr Asp Leu Asp Tyr Leu Leu Leu His Gln Ala Asn Asp Arg Ile Leu 
                245                 250                 255     

Asp Lys Met Ala Arg Lys Ile Gly Val Asp Arg Ala Lys Leu Pro Ala 
            260                 265                 270         

Asn Met Met Glu Tyr Gly Asn Thr Ser Ala Ala Ser Ile Pro Ile Leu 
        275                 280                 285             

Leu Ser Glu Cys Val Glu Gln Gly Leu Ile Pro Leu Asp Gly Ser Gln 
    290                 295                 300                 

Thr Val Leu Leu Ser Gly Phe Gly Gly Gly Leu Thr Trp Gly Thr Leu 
305                 310                 315                 320 

Ile Leu Thr Ile 
                

<210>   679
<211>   222
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   679
atggcagtat ttgaaaaagt acaagaaatt atcgttgaag aacttggaaa agacgcatca   60
gaagtaacac ttgaatcaac ttttgatgat ttggacgcag attcattgga cttgttccaa   120
gtaatctcag aaatcgaaga tgcttttgat atccaaatcg aagcagaaaa tgacttgaaa   180
acagttggtg acttggttgc ttacgttgaa gagcaagcaa aa                      222

<210>   680
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acyl carrier protein (acpP)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902422 (3.E-36)

<400>   680
Met Ala Val Phe Glu Lys Val Gln Glu Ile Ile Val Glu Glu Leu Gly 
1               5                   10                  15      

Lys Asp Ala Ser Glu Val Thr Leu Glu Ser Thr Phe Asp Asp Leu Asp 
            20                  25                  30          

Ala Asp Ser Leu Asp Leu Phe Gln Val Ile Ser Glu Ile Glu Asp Ala 
        35                  40                  45              

Phe Asp Ile Gln Ile Glu Ala Glu Asn Asp Leu Lys Thr Val Gly Asp 
    50                  55                  60                  

Leu Val Ala Tyr Val Glu Glu Gln Ala Lys 
65                  70                  

<210>   681
<211>   972
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   681
atgaaaacgc gtattacaga attattgaag attgattatc ctattttcca aggagggatg   60
gcctgggttg ctgatggtga tttggcaggg gctgtttcca aggctggagg attaggaatt   120
atcggtgggg gaaatgcccc gaaagaagtt gtcaaggcca atattgataa aatcaaatca   180
ttgactgata aaccctttgg ggtcaacatc atgctcttat ctccctttgt ggaagacatc   240
gtggatctcg ttattgaaga aggtgttaaa gttgtcacaa caggagcagg aaatccaagc   300
aagtatatgg aacgtttcca tgaagctggg ataatcgtta ttcctgttgt tcctagtgtc   360
gctttagcta aacgcatgga aaaaatcggt gcagacgctg ttattgcaga aggaatggaa   420
gctggggggc atatcggtaa attaacaacc atgaccttgg tgcgacaggt agccacagct   480
atatctattc ctgttattgc tgcaggagga attgcggatg gtgaaggtgc tgcggctggc   540
tttatgctag gtgcagaggc tgtacaggtg gggacacggt ttgtagttgc aaaagagtcg   600
aatgcccatc caaactacaa ggagaaaatt ttaaaagcaa gggatattga tactacgatt   660
tcagctcagc actttggtca tgctgttcgt gctattaaaa atcagttgac tagagatttt   720
gaactggctg aaaaagatgc ctttaagcaa gaagatcctg atttagaaat ctttgaacaa   780
atgggagcag gtgctctagc caaagcagtt gttcacggtg atgtggatgg tggctctgtt   840
atggcaggtc aaatcgcagg gcttgtttct aaagaagaaa cagctgaaga aatcctaaaa   900
gatttgtatt acggagccgc taagaaaatt caagaagaag cctctcgctg gacaggagtt   960
gtaagaaatg ac                                                       972

<210>   682
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   trans-2-enoyl-ACP reductase (fabK)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902423 (0.E+01)

<400>   682
Met Lys Thr Arg Ile Thr Glu Leu Leu Lys Ile Asp Tyr Pro Ile Phe 
1               5                   10                  15      

Gln Gly Gly Met Ala Trp Val Ala Asp Gly Asp Leu Ala Gly Ala Val 
            20                  25                  30          

Ser Lys Ala Gly Gly Leu Gly Ile Ile Gly Gly Gly Asn Ala Pro Lys 
        35                  40                  45              

Glu Val Val Lys Ala Asn Ile Asp Lys Ile Lys Ser Leu Thr Asp Lys 
    50                  55                  60                  

Pro Phe Gly Val Asn Ile Met Leu Leu Ser Pro Phe Val Glu Asp Ile 
65                  70                  75                  80  

Val Asp Leu Val Ile Glu Glu Gly Val Lys Val Val Thr Thr Gly Ala 
                85                  90                  95      

Gly Asn Pro Ser Lys Tyr Met Glu Arg Phe His Glu Ala Gly Ile Ile 
            100                 105                 110         

Val Ile Pro Val Val Pro Ser Val Ala Leu Ala Lys Arg Met Glu Lys 
        115                 120                 125             

Ile Gly Ala Asp Ala Val Ile Ala Glu Gly Met Glu Ala Gly Gly His 
    130                 135                 140                 

Ile Gly Lys Leu Thr Thr Met Thr Leu Val Arg Gln Val Ala Thr Ala 
145                 150                 155                 160 

Ile Ser Ile Pro Val Ile Ala Ala Gly Gly Ile Ala Asp Gly Glu Gly 
                165                 170                 175     

Ala Ala Ala Gly Phe Met Leu Gly Ala Glu Ala Val Gln Val Gly Thr 
            180                 185                 190         

Arg Phe Val Val Ala Lys Glu Ser Asn Ala His Pro Asn Tyr Lys Glu 
        195                 200                 205             

Lys Ile Leu Lys Ala Arg Asp Ile Asp Thr Thr Ile Ser Ala Gln His 
    210                 215                 220                 

Phe Gly His Ala Val Arg Ala Ile Lys Asn Gln Leu Thr Arg Asp Phe 
225                 230                 235                 240 

Glu Leu Ala Glu Lys Asp Ala Phe Lys Gln Glu Asp Pro Asp Leu Glu 
                245                 250                 255     

Ile Phe Glu Gln Met Gly Ala Gly Ala Leu Ala Lys Ala Val Val His 
            260                 265                 270         

Gly Asp Val Asp Gly Gly Ser Val Met Ala Gly Gln Ile Ala Gly Leu 
        275                 280                 285             

Val Ser Lys Glu Glu Thr Ala Glu Glu Ile Leu Lys Asp Leu Tyr Tyr 
    290                 295                 300                 

Gly Ala Ala Lys Lys Ile Gln Glu Glu Ala Ser Arg Trp Thr Gly Val 
305                 310                 315                 320 

Val Arg Asn Asp 
                

<210>   683
<211>   918
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   683
atgactaaaa cagccttttt atttgctggt caaggtgccc agtatctagg gatgggacgg   60
gatttctatg atcagtatcc gattgttaaa gaaacgattg atcgagcgag ccaggtgctc   120
ggttatgatt tgcgttatct catcgatacg gaagaagaca aactcaatca gacccgctat   180
acgcaaccag ccattctagc gacttcggtt gctatctacc gtttattgca agaaaagggc   240
tatcagcctg atatggttgc tggtttgtct cttggagaat actctgcctt ggtggcaagt   300
ggcgccttgg attttgaaga tgcggttgcc ttggtagcta agcgtggagc ctatatggaa   360
gaagcggctc ctgctgactc tggcaagatg gtagcagttc tcaatacgcc agtagaggtc   420
attgaagaag cctgtcaaaa agcttctgaa cttggagtgg ttactccagc caactataac   480
acacctgcac aaatcgtcat tgctggagaa gtggttgcag ttgatcgagc ggttgaactt   540
ttgcaagaag caggtgccaa acgcttgatt cctcttaagg tgtcaggtcc ctttcacacc   600
gctctccttg aacctgctag ccagaaacta gctgaaactc tagctcaggt aagtttttca   660
gattttactt gtcccctagt cggcaataca gaagctgctg tgatgcaaaa agaggacatt   720
gctcagctct tgacgcgtca ggtcaaggaa cccgttcgtt tctatgaaag tattggggtc   780
atgcaagaag caggcataag caactttatc gagattggac cggggaaagt cttgtcaggt   840
tttgttaaaa aaattgatca aactgctcac ttagctcatg tggaagatca agcgagttta   900
gtagcacttt tagaaaaa                                                 918

<210>   684
<211>   306
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   malonyl CoA-acyl carrier protein transacylase (fabD)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902424 (e-169)

<400>   684
Met Thr Lys Thr Ala Phe Leu Phe Ala Gly Gln Gly Ala Gln Tyr Leu 
1               5                   10                  15      

Gly Met Gly Arg Asp Phe Tyr Asp Gln Tyr Pro Ile Val Lys Glu Thr 
            20                  25                  30          

Ile Asp Arg Ala Ser Gln Val Leu Gly Tyr Asp Leu Arg Tyr Leu Ile 
        35                  40                  45              

Asp Thr Glu Glu Asp Lys Leu Asn Gln Thr Arg Tyr Thr Gln Pro Ala 
    50                  55                  60                  

Ile Leu Ala Thr Ser Val Ala Ile Tyr Arg Leu Leu Gln Glu Lys Gly 
65                  70                  75                  80  

Tyr Gln Pro Asp Met Val Ala Gly Leu Ser Leu Gly Glu Tyr Ser Ala 
                85                  90                  95      

Leu Val Ala Ser Gly Ala Leu Asp Phe Glu Asp Ala Val Ala Leu Val 
            100                 105                 110         

Ala Lys Arg Gly Ala Tyr Met Glu Glu Ala Ala Pro Ala Asp Ser Gly 
        115                 120                 125             

Lys Met Val Ala Val Leu Asn Thr Pro Val Glu Val Ile Glu Glu Ala 
    130                 135                 140                 

Cys Gln Lys Ala Ser Glu Leu Gly Val Val Thr Pro Ala Asn Tyr Asn 
145                 150                 155                 160 

Thr Pro Ala Gln Ile Val Ile Ala Gly Glu Val Val Ala Val Asp Arg 
                165                 170                 175     

Ala Val Glu Leu Leu Gln Glu Ala Gly Ala Lys Arg Leu Ile Pro Leu 
            180                 185                 190         

Lys Val Ser Gly Pro Phe His Thr Ala Leu Leu Glu Pro Ala Ser Gln 
        195                 200                 205             

Lys Leu Ala Glu Thr Leu Ala Gln Val Ser Phe Ser Asp Phe Thr Cys 
    210                 215                 220                 

Pro Leu Val Gly Asn Thr Glu Ala Ala Val Met Gln Lys Glu Asp Ile 
225                 230                 235                 240 

Ala Gln Leu Leu Thr Arg Gln Val Lys Glu Pro Val Arg Phe Tyr Glu 
                245                 250                 255     

Ser Ile Gly Val Met Gln Glu Ala Gly Ile Ser Asn Phe Ile Glu Ile 
            260                 265                 270         

Gly Pro Gly Lys Val Leu Ser Gly Phe Val Lys Lys Ile Asp Gln Thr 
        275                 280                 285             

Ala His Leu Ala His Val Glu Asp Gln Ala Ser Leu Val Ala Leu Leu 
    290                 295                 300                 

Glu Lys 
305     

<210>   685
<211>   729
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   685
atgaaactag aacataaaaa tatctttatt acaggttcga gtcgtggaat tggtcttgcc   60
atcgcccaca agtttgctca agcaggagcc aacattgtct taaacagtcg tggggcaatc   120
tcagaagaat tgctcgctga gttttcaaac tatggtatca aggtggttcc catttcagga   180
gatgtatcag attttgcaga cgctaagcgt atgattgatc aagctattgc agaactgggt   240
tcagtagatg ttttggtcaa caatgcaggg attacccaag atactcttat gctcaagatg   300
acagaagcag attttgaaaa agtgctcaag gtcaatctga ctggtgcctt taatatgaca   360
caatcagtct tgaaaccgat gatgaaagcc agagaaggtg ctatcattaa tatgtctagt   420
gttgttggtt tgatggggaa tattggtcaa gctaattatg ctgcttctaa ggctggcttg   480
attggcttta ccaagtctgt ggcacgcgag gtcgctagtc ggaatatacg agtcaatgtg   540
attgctccag gaatgattga gtctgatatg accgctatcc tgtcagataa gattaaggaa   600
gctacactag ctcagattcc gatgaaagaa tttgggcagg cagagcaggt tgcagatttg   660
acagtatttt tagcaggcca agattatcta actggacaag tggttgccat tgatggtggc   720
ttaagtatg                                                           729

<210>   686
<211>   243
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-oxoacyl-[acyl-carrier protein] reductase (fabG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902425 (e-131)

<400>   686
Met Lys Leu Glu His Lys Asn Ile Phe Ile Thr Gly Ser Ser Arg Gly 
1               5                   10                  15      

Ile Gly Leu Ala Ile Ala His Lys Phe Ala Gln Ala Gly Ala Asn Ile 

            20                  25                  30          

Val Leu Asn Ser Arg Gly Ala Ile Ser Glu Glu Leu Leu Ala Glu Phe 
        35                  40                  45              

Ser Asn Tyr Gly Ile Lys Val Val Pro Ile Ser Gly Asp Val Ser Asp 
    50                  55                  60                  

Phe Ala Asp Ala Lys Arg Met Ile Asp Gln Ala Ile Ala Glu Leu Gly 
65                  70                  75                  80  

Ser Val Asp Val Leu Val Asn Asn Ala Gly Ile Thr Gln Asp Thr Leu 
                85                  90                  95      

Met Leu Lys Met Thr Glu Ala Asp Phe Glu Lys Val Leu Lys Val Asn 
            100                 105                 110         

Leu Thr Gly Ala Phe Asn Met Thr Gln Ser Val Leu Lys Pro Met Met 
        115                 120                 125             

Lys Ala Arg Glu Gly Ala Ile Ile Asn Met Ser Ser Val Val Gly Leu 
    130                 135                 140                 

Met Gly Asn Ile Gly Gln Ala Asn Tyr Ala Ala Ser Lys Ala Gly Leu 
145                 150                 155                 160 

Ile Gly Phe Thr Lys Ser Val Ala Arg Glu Val Ala Ser Arg Asn Ile 
                165                 170                 175     

Arg Val Asn Val Ile Ala Pro Gly Met Ile Glu Ser Asp Met Thr Ala 
            180                 185                 190         

Ile Leu Ser Asp Lys Ile Lys Glu Ala Thr Leu Ala Gln Ile Pro Met 
        195                 200                 205             

Lys Glu Phe Gly Gln Ala Glu Gln Val Ala Asp Leu Thr Val Phe Leu 
    210                 215                 220                 

Ala Gly Gln Asp Tyr Leu Thr Gly Gln Val Val Ala Ile Asp Gly Gly 
225                 230                 235                 240 

Leu Ser Met 
            

<210>   687
<211>   1242
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   687
gtgaaaagaa tgaaactaaa tcgagtagtg gtaacaggtt atggagtaac atctccaatc   60
ggaaatacac cagaagaatt ttggaatagt ttagcaactg ggaaaatcgg cattggtggc   120
attacaaaat ttgatcatag tgactttgat gtgcataatg cggcagaaat ccaagatttt   180
ccgttcgata aatactttgt aaaaaaagat accaaccgtt ttgataacta ttctttatat   240
gccttgtatg cagcccaaga ggctgtaaat catgccaatc ttgatgtaga ggctcttaat   300
agggatcgtt ttggtgttat cgttgcatct ggtattggtg gaatcaagga aattgaagat   360
caggtacttc gccttcatga aaaaggaccc aaacgtgtca aaccaatgac tcttccaaaa   420
gctttaccaa atatggcttc tgggaatgta gccatgcgtt ttggtgcaaa cggtgtttgt   480
aaatctatca atactgcctg ctcttcatca aatgatgcga ttggggatgc cttccgctcc   540
attaagtttg gtttccaaga tgtgatgttg gtgggaggaa cagaagcttc tatcacacct   600
tttgccatcg ctggtttcca agccttaaca gctctctcta ctacagagga tccaactcgt   660
gcttcgatcc catttgataa ggatcgcaat gggtttgtta tgggtgaagg ttcagggatg   720
ttggttctag aaagtcttga acacgctgaa aaacgtggag ctactatcct ggctgaagtg   780
gttggttacg gaaatacttg tgatgcctac cacatgactt ctccacatcc agaaggtcag   840
ggagctatca aggccatcaa actagccttg gaagaagctg agatttctcc agagcaagta   900
gcctatgtca atgctcacgg aacgtcaact cctgccaatg aaaaaggaga aagtggtgct   960
atcgtagctg ttcttggtaa ggaagtacct gtatcatcaa ccaagtcttt tacaggacat   1020
ttgctggggg ctgcgggtgc agtagaagct atcgtcacca tcgaagctat gcgtcataac   1080
tttgtaccaa tgacagctgg gacaagtgaa gtatcagatt atatcgaagc taatgtcgtt   1140
tatggacaag gcttggagaa agaaattcca tacgctattt caaatacttt tggttttgga   1200
ggccacaatg cagttcttgc tttcaaacgt tgggagaata ga                      1242

<210>   688
<211>   414
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-oxoacyl-(acyl-carrier-protein) synthase II (fabF)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902426 (0.E+01)

<400>   688
Met Lys Arg Met Lys Leu Asn Arg Val Val Val Thr Gly Tyr Gly Val 
1               5                   10                  15      

Thr Ser Pro Ile Gly Asn Thr Pro Glu Glu Phe Trp Asn Ser Leu Ala 
            20                  25                  30          

Thr Gly Lys Ile Gly Ile Gly Gly Ile Thr Lys Phe Asp His Ser Asp 
        35                  40                  45              

Phe Asp Val His Asn Ala Ala Glu Ile Gln Asp Phe Pro Phe Asp Lys 
    50                  55                  60                  

Tyr Phe Val Lys Lys Asp Thr Asn Arg Phe Asp Asn Tyr Ser Leu Tyr 
65                  70                  75                  80  

Ala Leu Tyr Ala Ala Gln Glu Ala Val Asn His Ala Asn Leu Asp Val 
                85                  90                  95      

Glu Ala Leu Asn Arg Asp Arg Phe Gly Val Ile Val Ala Ser Gly Ile 
            100                 105                 110         

Gly Gly Ile Lys Glu Ile Glu Asp Gln Val Leu Arg Leu His Glu Lys 
        115                 120                 125             

Gly Pro Lys Arg Val Lys Pro Met Thr Leu Pro Lys Ala Leu Pro Asn 
    130                 135                 140                 

Met Ala Ser Gly Asn Val Ala Met Arg Phe Gly Ala Asn Gly Val Cys 
145                 150                 155                 160 

Lys Ser Ile Asn Thr Ala Cys Ser Ser Ser Asn Asp Ala Ile Gly Asp 
                165                 170                 175     

Ala Phe Arg Ser Ile Lys Phe Gly Phe Gln Asp Val Met Leu Val Gly 
            180                 185                 190         

Gly Thr Glu Ala Ser Ile Thr Pro Phe Ala Ile Ala Gly Phe Gln Ala 
        195                 200                 205             

Leu Thr Ala Leu Ser Thr Thr Glu Asp Pro Thr Arg Ala Ser Ile Pro 
    210                 215                 220                 

Phe Asp Lys Asp Arg Asn Gly Phe Val Met Gly Glu Gly Ser Gly Met 
225                 230                 235                 240 

Leu Val Leu Glu Ser Leu Glu His Ala Glu Lys Arg Gly Ala Thr Ile 
                245                 250                 255     

Leu Ala Glu Val Val Gly Tyr Gly Asn Thr Cys Asp Ala Tyr His Met 
            260                 265                 270         

Thr Ser Pro His Pro Glu Gly Gln Gly Ala Ile Lys Ala Ile Lys Leu 
        275                 280                 285             

Ala Leu Glu Glu Ala Glu Ile Ser Pro Glu Gln Val Ala Tyr Val Asn 
    290                 295                 300                 

Ala His Gly Thr Ser Thr Pro Ala Asn Glu Lys Gly Glu Ser Gly Ala 
305                 310                 315                 320 

Ile Val Ala Val Leu Gly Lys Glu Val Pro Val Ser Ser Thr Lys Ser 
                325                 330                 335     

Phe Thr Gly His Leu Leu Gly Ala Ala Gly Ala Val Glu Ala Ile Val 
            340                 345                 350         

Thr Ile Glu Ala Met Arg His Asn Phe Val Pro Met Thr Ala Gly Thr 
        355                 360                 365             

Ser Glu Val Ser Asp Tyr Ile Glu Ala Asn Val Val Tyr Gly Gln Gly 
    370                 375                 380                 

Leu Glu Lys Glu Ile Pro Tyr Ala Ile Ser Asn Thr Phe Gly Phe Gly 
385                 390                 395                 400 

Gly His Asn Ala Val Leu Ala Phe Lys Arg Trp Glu Asn Arg 
                405                 410                 

<210>   689
<211>   483
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   689
atgaatttaa acgatattaa agacttgatg actcaatttg accagtcaag tttgagagaa   60
ttttcttata aaaatgggac ggatgagttg cagtttagca agaatgaagc aagacctgtg   120
cctgaagttg caactcaagt cgctccagca cccgttctag caacaccgag tccagtagct   180
cctacatctg ctccagcaga gactgtagca gaagaagttc cagctccagc tgaagcaagt   240
gtggctactg agggaaatct tgtagagagt ccacttgttg gagtggttta cttggctgct   300
ggaccagata aacctgcctt cgttacagtt ggtgatagtg tcaaaaaagg tcaaacattg   360
gtaattatcg aagccatgaa agtcatgaat gaaatcccag ctcctaagga tggtgtggta   420
acggaaattc tcgtctctaa cgaagaaatg gttgagtttg gtaaaggatt ggtacgtatc   480
aaa                                                                 483

<210>   690
<211>   161
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyl-CoA carboxylase, bitoin carboxyl carrier protein (accB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902427 (4.E-87)

<400>   690
Met Asn Leu Asn Asp Ile Lys Asp Leu Met Thr Gln Phe Asp Gln Ser 
1               5                   10                  15      

Ser Leu Arg Glu Phe Ser Tyr Lys Asn Gly Thr Asp Glu Leu Gln Phe 
            20                  25                  30          

Ser Lys Asn Glu Ala Arg Pro Val Pro Glu Val Ala Thr Gln Val Ala 
        35                  40                  45              

Pro Ala Pro Val Leu Ala Thr Pro Ser Pro Val Ala Pro Thr Ser Ala 
    50                  55                  60                  

Pro Ala Glu Thr Val Ala Glu Glu Val Pro Ala Pro Ala Glu Ala Ser 
65                  70                  75                  80  

Val Ala Thr Glu Gly Asn Leu Val Glu Ser Pro Leu Val Gly Val Val 
                85                  90                  95      

Tyr Leu Ala Ala Gly Pro Asp Lys Pro Ala Phe Val Thr Val Gly Asp 
            100                 105                 110         

Ser Val Lys Lys Gly Gln Thr Leu Val Ile Ile Glu Ala Met Lys Val 
        115                 120                 125             

Met Asn Glu Ile Pro Ala Pro Lys Asp Gly Val Val Thr Glu Ile Leu 
    130                 135                 140                 

Val Ser Asn Glu Glu Met Val Glu Phe Gly Lys Gly Leu Val Arg Ile 
145                 150                 155                 160 

Lys 
    

<210>   691
<211>   420
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   691
atgatcgata ttcaaggaat caaagaagct cttccccacc gttatcctat gcttctagtg   60
gaccgtgtct tggaagtgag cgaggatacc attgttgcta tcaaaaatgt gaccatcaac   120
gagcctttct ttaacggcca ctttcctcaa tacccagtta tgccaggtgt tgtgattatg   180
gaagccttgg cgcaaactgc cggtgtgttg gagttatcaa aacctgaaaa taaaggaaaa   240
ctggtctttt acgctggtat ggacaaggtt aagttcaaga agcaagttgt accaggcgac   300
caattggtta tgacagcgac ttttgtaaaa cgtcgtggca ccatagctgt ggttgaagca   360
aaggctgaag tggatggcaa gcttgcagcc agtggtaccc ttacttttgc aattgggaac   420

<210>   692
<211>   140
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase (fabZ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902428 (7.E-75)

<400>   692
Met Ile Asp Ile Gln Gly Ile Lys Glu Ala Leu Pro His Arg Tyr Pro 
1               5                   10                  15      

Met Leu Leu Val Asp Arg Val Leu Glu Val Ser Glu Asp Thr Ile Val 
            20                  25                  30          

Ala Ile Lys Asn Val Thr Ile Asn Glu Pro Phe Phe Asn Gly His Phe 
        35                  40                  45              

Pro Gln Tyr Pro Val Met Pro Gly Val Val Ile Met Glu Ala Leu Ala 
    50                  55                  60                  

Gln Thr Ala Gly Val Leu Glu Leu Ser Lys Pro Glu Asn Lys Gly Lys 
65                  70                  75                  80  

Leu Val Phe Tyr Ala Gly Met Asp Lys Val Lys Phe Lys Lys Gln Val 
                85                  90                  95      

Val Pro Gly Asp Gln Leu Val Met Thr Ala Thr Phe Val Lys Arg Arg 
            100                 105                 110         

Gly Thr Ile Ala Val Val Glu Ala Lys Ala Glu Val Asp Gly Lys Leu 
        115                 120                 125             

Ala Ala Ser Gly Thr Leu Thr Phe Ala Ile Gly Asn 
    130                 135                 140 

<210>   693
<211>   1365
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   693
atgtttcgaa aaattttaat tgccaatcgt ggtgaaattg cggttcgtat tatccgtgcg   60
gcacgtgaat tggggattgc gacggtagcg gtttattcaa ctgctgataa ggaagctctt   120
catacgcttt tggcagatga agcagtttgt attggtcctg gcaaggcaac agagtcttat   180
ctcaatatta atgcagttct atcagctgca gtcttgactg aggcagaagc tattcaccct   240
ggttttggat ttctcagtga aaattccaaa tttgcgacca tgtgtgaaga agtaggtatc   300
aagtttatcg gtccatctgg tcatgttatg gatatgatgg gggataagat caatgcgcgt   360
gctcagatga ttaaagcagg tgtgcctgtt ataccaggtt cagatggaga agtgcataac   420
tctgaagaag ctttgattgt tgctgaaaaa attggctatc ctgttatgct caaggcttca   480
gcaggtggag gtggtaaagg gattcgtaag gttgaaaaac cagatgacct cgtttctgcc   540
tttgaaactg cctctagtga ggccaaggcc aattatggca atggtgccat gtacatagaa   600
cgggttatct atccagctcg gcacattgag gttcaaatcc taggtgatga gcatggacat   660
gtgattcact tgggtgaacg ggattgttct cttcaaagga ataaccaaaa ggttttggaa   720
gaaagtccct cgattgcaat cggaaaaacg ctgcgtcatg aaataggtgc tgctgctgtt   780
cgagcggcag agtttgttgg ctatgagaat gcaggaacca ttgaatttct tcttgatgaa   840
gcaagtagca atttctattt catggagatg aatactcgtg ttcaggtaga acatccagta   900
acagagtttg tttcaggtgt tgatatcgtt aaggaacaga tttgcattgc ggcaggtcag   960
cctttgtctg ttaagcaaga agatattgtc ctacgcggtc atgccatcga gtgtcgtatc   1020
aatgcagaaa acccagcctt taactttgct ccaagtccag gtaagattac taatctctat   1080
ctgccaagtg gtggagttgg cttgcgcgtg gattcagcag tttatccagg ttataccatt   1140
ccgccttatt atgatagtat gattgccaaa atcatagtac acggcgaaaa tcgttttgac   1200
gccttgatga aaatgcaacg tgccctctat gaattagaaa ttgaaggagt gcagaccaat   1260
gcagatttcc agcttgacct catttcagat cgcaatgtca ttgctgggga ttatgatact   1320
tccttcttga tggaaacctt cttacctaaa tatcaagaaa aagaa                   1365

<210>   694
<211>   455
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyl-CoA carboxylase, biotin carboxylase (accC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902429 (0.E+01)

<400>   694
Met Phe Arg Lys Ile Leu Ile Ala Asn Arg Gly Glu Ile Ala Val Arg 
1               5                   10                  15      

Ile Ile Arg Ala Ala Arg Glu Leu Gly Ile Ala Thr Val Ala Val Tyr 
            20                  25                  30          

Ser Thr Ala Asp Lys Glu Ala Leu His Thr Leu Leu Ala Asp Glu Ala 
        35                  40                  45              

Val Cys Ile Gly Pro Gly Lys Ala Thr Glu Ser Tyr Leu Asn Ile Asn 
    50                  55                  60                  

Ala Val Leu Ser Ala Ala Val Leu Thr Glu Ala Glu Ala Ile His Pro 
65                  70                  75                  80  

Gly Phe Gly Phe Leu Ser Glu Asn Ser Lys Phe Ala Thr Met Cys Glu 
                85                  90                  95      

Glu Val Gly Ile Lys Phe Ile Gly Pro Ser Gly His Val Met Asp Met 
            100                 105                 110         

Met Gly Asp Lys Ile Asn Ala Arg Ala Gln Met Ile Lys Ala Gly Val 
        115                 120                 125             

Pro Val Ile Pro Gly Ser Asp Gly Glu Val His Asn Ser Glu Glu Ala 
    130                 135                 140                 

Leu Ile Val Ala Glu Lys Ile Gly Tyr Pro Val Met Leu Lys Ala Ser 
145                 150                 155                 160 

Ala Gly Gly Gly Gly Lys Gly Ile Arg Lys Val Glu Lys Pro Asp Asp 
                165                 170                 175     

Leu Val Ser Ala Phe Glu Thr Ala Ser Ser Glu Ala Lys Ala Asn Tyr 
            180                 185                 190         

Gly Asn Gly Ala Met Tyr Ile Glu Arg Val Ile Tyr Pro Ala Arg His 
        195                 200                 205             

Ile Glu Val Gln Ile Leu Gly Asp Glu His Gly His Val Ile His Leu 
    210                 215                 220                 

Gly Glu Arg Asp Cys Ser Leu Gln Arg Asn Asn Gln Lys Val Leu Glu 
225                 230                 235                 240 

Glu Ser Pro Ser Ile Ala Ile Gly Lys Thr Leu Arg His Glu Ile Gly 
                245                 250                 255     

Ala Ala Ala Val Arg Ala Ala Glu Phe Val Gly Tyr Glu Asn Ala Gly 
            260                 265                 270         

Thr Ile Glu Phe Leu Leu Asp Glu Ala Ser Ser Asn Phe Tyr Phe Met 
        275                 280                 285             

Glu Met Asn Thr Arg Val Gln Val Glu His Pro Val Thr Glu Phe Val 
    290                 295                 300                 

Ser Gly Val Asp Ile Val Lys Glu Gln Ile Cys Ile Ala Ala Gly Gln 
305                 310                 315                 320 

Pro Leu Ser Val Lys Gln Glu Asp Ile Val Leu Arg Gly His Ala Ile 
                325                 330                 335     

Glu Cys Arg Ile Asn Ala Glu Asn Pro Ala Phe Asn Phe Ala Pro Ser 
            340                 345                 350         

Pro Gly Lys Ile Thr Asn Leu Tyr Leu Pro Ser Gly Gly Val Gly Leu 
        355                 360                 365             

Arg Val Asp Ser Ala Val Tyr Pro Gly Tyr Thr Ile Pro Pro Tyr Tyr 
    370                 375                 380                 

Asp Ser Met Ile Ala Lys Ile Ile Val His Gly Glu Asn Arg Phe Asp 
385                 390                 395                 400 

Ala Leu Met Lys Met Gln Arg Ala Leu Tyr Glu Leu Glu Ile Glu Gly 
                405                 410                 415     

Val Gln Thr Asn Ala Asp Phe Gln Leu Asp Leu Ile Ser Asp Arg Asn 
            420                 425                 430         

Val Ile Ala Gly Asp Tyr Asp Thr Ser Phe Leu Met Glu Thr Phe Leu 
        435                 440                 445             

Pro Lys Tyr Gln Glu Lys Glu 
    450                 455 

<210>   695
<211>   864
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   695
atggctctat ttagtaaaaa agataagtat attcgaatca atcccaatcg ttcggttagg   60
gaaaaacctc aagctaagcc agaggttcca gatgaattat tttcccagtg tccaggctgt   120
aagcatacca tctatcagaa ggatctggga agtgaacgta tctgtccgca ctgtagctat   180
acctttcgta tttctgccca agaacgcttg gctttgacga ttgatatggg aaccttcaaa   240
gaattgttta cagggattga aagcaaggat cccttgcatt tccctggtta ccaaaagaaa   300
ctggcatcta tgcgtgaaaa aacaggtctg catgaagccg ttgtgacagg aactgctctt   360
attaaaggtc agactgtggc tcttgggatt atggattcta actttatcat ggcttctatg   420
ggtacggttg taggtgaaaa aatcactcgt ttgtttgagt atgcgactgt cgaaaaattg   480
ccagttgtcc tattcacagc ctctggtgga gcccgtatgc aggaaggaat catgagtctc   540
atgcagatgg ctaagatctc tgcggcggtt aaacgccatt caaatgctgg tctcttttac   600
ctgaccattt tgacagatcc aacgactggt ggtgtgacag cttctttcgc tatggaaggc   660
gatatcattc tggctgaacc acagagcttg gttggttttg ctgggcgtcg tgtgattgaa   720
aatacggttc gtgaaagctt gcctgaggat ttccaaaagg cagaattcct attagaacat   780
ggctttgtgg atgctattgt caaaagaaga gacttaccag atacgattgc tagcctagtc   840
agattgcatg gagggagtcc taga                                          864

<210>   696
<211>   288
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyl-CoA carboxylase, carboxyl transferase subunit beta (accD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902430 (e-164)

<400>   696
Met Ala Leu Phe Ser Lys Lys Asp Lys Tyr Ile Arg Ile Asn Pro Asn 
1               5                   10                  15      

Arg Ser Val Arg Glu Lys Pro Gln Ala Lys Pro Glu Val Pro Asp Glu 
            20                  25                  30          

Leu Phe Ser Gln Cys Pro Gly Cys Lys His Thr Ile Tyr Gln Lys Asp 
        35                  40                  45              

Leu Gly Ser Glu Arg Ile Cys Pro His Cys Ser Tyr Thr Phe Arg Ile 
    50                  55                  60                  


Ser Ala Gln Glu Arg Leu Ala Leu Thr Ile Asp Met Gly Thr Phe Lys 
65                  70                  75                  80  

Glu Leu Phe Thr Gly Ile Glu Ser Lys Asp Pro Leu His Phe Pro Gly 
                85                  90                  95      

Tyr Gln Lys Lys Leu Ala Ser Met Arg Glu Lys Thr Gly Leu His Glu 
            100                 105                 110         

Ala Val Val Thr Gly Thr Ala Leu Ile Lys Gly Gln Thr Val Ala Leu 
        115                 120                 125             

Gly Ile Met Asp Ser Asn Phe Ile Met Ala Ser Met Gly Thr Val Val 
    130                 135                 140                 

Gly Glu Lys Ile Thr Arg Leu Phe Glu Tyr Ala Thr Val Glu Lys Leu 
145                 150                 155                 160 

Pro Val Val Leu Phe Thr Ala Ser Gly Gly Ala Arg Met Gln Glu Gly 
                165                 170                 175     

Ile Met Ser Leu Met Gln Met Ala Lys Ile Ser Ala Ala Val Lys Arg 
            180                 185                 190         

His Ser Asn Ala Gly Leu Phe Tyr Leu Thr Ile Leu Thr Asp Pro Thr 
        195                 200                 205             

Thr Gly Gly Val Thr Ala Ser Phe Ala Met Glu Gly Asp Ile Ile Leu 
    210                 215                 220                 

Ala Glu Pro Gln Ser Leu Val Gly Phe Ala Gly Arg Arg Val Ile Glu 
225                 230                 235                 240 

Asn Thr Val Arg Glu Ser Leu Pro Glu Asp Phe Gln Lys Ala Glu Phe 
                245                 250                 255     

Leu Leu Glu His Gly Phe Val Asp Ala Ile Val Lys Arg Arg Asp Leu 
            260                 265                 270         

Pro Asp Thr Ile Ala Ser Leu Val Arg Leu His Gly Gly Ser Pro Arg 
        275                 280                 285             


<210>   697
<211>   765
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   697
atgaatattg caaaaatagt cagagaagcg cgtgagcaga gtcgcttgac aaccttggac   60
tttgcgacag gcatttttga tgaatttatc caattacatg gtgaccgttc ttttcgtgat   120
gatggtgcag ttgttggtgg tattggttgg cttggagacc aagctgtaac agtggttggt   180
atccaaaaag gcaagagttt gcaagacaac ctcaaacgga attttggcca accacatcca   240
gaaggctacc gaaaggcact gcggttgatg aaacaggctg agaaatttgg ccgtccagtt   300
gtgaccttta tcaatacagc aggtgcttat cctggtgtcg gagcggaaga acgtggtcaa   360
ggggaagcta tcgctcgcaa tctcatggaa atgagtgacc tgaaagttcc tattatcgcc   420
attattatcg gtgaaggtgg ttcaggcggg gctctggctc tagctgtcgc ggaccgtgtc   480
tggatgctgg aaaattctat ctatgccatt ctcagtccag aaggctttgc ttccatttta   540
tggaaggacg gtactcgcgc tatggaagca gcagaactga tgaaaatcac ttcgcatgaa   600
ctgttagaaa tggacgtggt ggataaggtg atttctgaaa taggactttc tagtaaagaa   660
ctgattaaga gtgtcaaaaa agaactccaa acggagctgg ctagactttc acaaaaaccg   720
ctagaagagt tgctggaaga acgctatcaa cgatttagaa aatac                   765

<210>   698
<211>   255
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyl-CoA carboxylase, carboxyl transferase subunit alpha (accA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902431 (e-142)

<400>   698
Met Asn Ile Ala Lys Ile Val Arg Glu Ala Arg Glu Gln Ser Arg Leu 
1               5                   10                  15      

Thr Thr Leu Asp Phe Ala Thr Gly Ile Phe Asp Glu Phe Ile Gln Leu 
            20                  25                  30          

His Gly Asp Arg Ser Phe Arg Asp Asp Gly Ala Val Val Gly Gly Ile 
        35                  40                  45              

Gly Trp Leu Gly Asp Gln Ala Val Thr Val Val Gly Ile Gln Lys Gly 
    50                  55                  60                  

Lys Ser Leu Gln Asp Asn Leu Lys Arg Asn Phe Gly Gln Pro His Pro 
65                  70                  75                  80  

Glu Gly Tyr Arg Lys Ala Leu Arg Leu Met Lys Gln Ala Glu Lys Phe 
                85                  90                  95      

Gly Arg Pro Val Val Thr Phe Ile Asn Thr Ala Gly Ala Tyr Pro Gly 
            100                 105                 110         

Val Gly Ala Glu Glu Arg Gly Gln Gly Glu Ala Ile Ala Arg Asn Leu 
        115                 120                 125             

Met Glu Met Ser Asp Leu Lys Val Pro Ile Ile Ala Ile Ile Ile Gly 
    130                 135                 140                 

Glu Gly Gly Ser Gly Gly Ala Leu Ala Leu Ala Val Ala Asp Arg Val 
145                 150                 155                 160 

Trp Met Leu Glu Asn Ser Ile Tyr Ala Ile Leu Ser Pro Glu Gly Phe 
                165                 170                 175     

Ala Ser Ile Leu Trp Lys Asp Gly Thr Arg Ala Met Glu Ala Ala Glu 
            180                 185                 190         

Leu Met Lys Ile Thr Ser His Glu Leu Leu Glu Met Asp Val Val Asp 
        195                 200                 205             

Lys Val Ile Ser Glu Ile Gly Leu Ser Ser Lys Glu Leu Ile Lys Ser 
    210                 215                 220                 

Val Lys Lys Glu Leu Gln Thr Glu Leu Ala Arg Leu Ser Gln Lys Pro 
225                 230                 235                 240 

Leu Glu Glu Leu Leu Glu Glu Arg Tyr Gln Arg Phe Arg Lys Tyr 
                245                 250                 255 

<210>   699
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   699
atgagactag aaaggtctca ttttttatgg aaaaatgtaa ttcaggtcga aaaattgcca   60
gttgaggaga tgggctataa aatagacaaa aaaagaaata tacta                   105

<210>   700
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   700
Met Arg Leu Glu Arg Ser His Phe Leu Trp Lys Asn Val Ile Gln Val 
1               5                   10                  15      

Glu Lys Leu Pro Val Glu Glu Met Gly Tyr Lys Ile Asp Lys Lys Arg 
            20                  25                  30          

Asn Ile Leu 
        35  

<210>   701
<211>   183
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   701
atgacaggta caaatacatt tacagttctt tcaactgagg acttggagca aacttcaggt   60
ggtcttgctg tttgggaaga tggatatagt agatggttat attatagaga atttgctccc   120
tatatgaggc aaggggcact taattcttat atagatgctt ggaagtacgg cttccgagca   180
ggg                                                                 183

<210>   702
<211>   61
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902432 (2.E-32)

<400>   702
Met Thr Gly Thr Asn Thr Phe Thr Val Leu Ser Thr Glu Asp Leu Glu 
1               5                   10                  15      

Gln Thr Ser Gly Gly Leu Ala Val Trp Glu Asp Gly Tyr Ser Arg Trp 
            20                  25                  30          


Leu Tyr Tyr Arg Glu Phe Ala Pro Tyr Met Arg Gln Gly Ala Leu Asn 
        35                  40                  45              

Ser Tyr Ile Asp Ala Trp Lys Tyr Gly Phe Arg Ala Gly 
    50                  55                  60      

<210>   703
<211>   516
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   703
ttggaagtac ggcttccgag cagggtaatc tttcaaaaaa gtacgatgag aaacacaaaa   60
aaactaagac aatttggaat atttttgctt attattttac tatctaccta tttaccacaa   120
acaattggat tgtatgtgac gatcatttta gggttaggag ctgatgtcta ttctcttatt   180
ttaacaatgg gattagtggg aagtttcctt ctattaattt ggaggttaaa aaagaaaaag   240
atgctcttta tctttgagaa aaagagctgg aactggtcat ttgtcttcta cttatttgca   300
acttatgtgg tttatcagat tctcggtaat ttttgggcac gctatgctca tttgattaat   360
cataggaata ttcatgatga gtattttacc gtgctttttt caaatggaca accaaccttt   420
ttatcgacta tcttatcttt tgtcctgcct gtaatcatcg gtcctgtttt tgaggagact   480
cttgatagag ggtattttat gaataccttc tttccc                             516

<210>   704
<211>   172
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902433 (1.E-36)

<400>   704
Met Glu Val Arg Leu Pro Ser Arg Val Ile Phe Gln Lys Ser Thr Met 
1               5                   10                  15      

Arg Asn Thr Lys Lys Leu Arg Gln Phe Gly Ile Phe Leu Leu Ile Ile 
            20                  25                  30          

Leu Leu Ser Thr Tyr Leu Pro Gln Thr Ile Gly Leu Tyr Val Thr Ile 
        35                  40                  45              

Ile Leu Gly Leu Gly Ala Asp Val Tyr Ser Leu Ile Leu Thr Met Gly 
    50                  55                  60                  

Leu Val Gly Ser Phe Leu Leu Leu Ile Trp Arg Leu Lys Lys Lys Lys 
65                  70                  75                  80  

Met Leu Phe Ile Phe Glu Lys Lys Ser Trp Asn Trp Ser Phe Val Phe 
                85                  90                  95      

Tyr Leu Phe Ala Thr Tyr Val Val Tyr Gln Ile Leu Gly Asn Phe Trp 
            100                 105                 110         

Ala Arg Tyr Ala His Leu Ile Asn His Arg Asn Ile His Asp Glu Tyr 
        115                 120                 125             

Phe Thr Val Leu Phe Ser Asn Gly Gln Pro Thr Phe Leu Ser Thr Ile 
    130                 135                 140                 

Leu Ser Phe Val Leu Pro Val Ile Ile Gly Pro Val Phe Glu Glu Thr 
145                 150                 155                 160 

Leu Asp Arg Gly Tyr Phe Met Asn Thr Phe Phe Pro 
                165                 170         

<210>   705
<211>   234
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   705
ttggatgtta tcctatctgc tatcatcttt gggattagcc atttgatact atctcacaga   60
gatccaatta gtttattata ttatagtctg attggtttct tttttgccct tgtttatcgt   120
tctaccgaca atctgagatt aacgattctc tgccatagtt tttttaactt tctcaatcat   180
gcaaaaccta tctggatttt tgtttacaat tatatctatt atcatttttt taga         234

<210>   706
<211>   78
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902870 (1.E-06)

<400>   706

Met Asp Val Ile Leu Ser Ala Ile Ile Phe Gly Ile Ser His Leu Ile 
1               5                   10                  15      

Leu Ser His Arg Asp Pro Ile Ser Leu Leu Tyr Tyr Ser Leu Ile Gly 
            20                  25                  30          

Phe Phe Phe Ala Leu Val Tyr Arg Ser Thr Asp Asn Leu Arg Leu Thr 
        35                  40                  45              

Ile Leu Cys His Ser Phe Phe Asn Phe Leu Asn His Ala Lys Pro Ile 
    50                  55                  60                  

Trp Ile Phe Val Tyr Asn Tyr Ile Tyr Tyr His Phe Phe Arg 
65                  70                  75              

<210>   707
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   707
gtgtttgata tctatcaaac actttttctt tttattgttg gctctataat atttgtagtg   60
ggtaaatccc ctatagatat tatggagcct attttattg                          99

<210>   708
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein, fusion

<400>   708
Met Phe Asp Ile Tyr Gln Thr Leu Phe Leu Phe Ile Val Gly Ser Ile 
1               5                   10                  15      

Ile Phe Val Val Gly Lys Ser Pro Ile Asp Ile Met Glu Pro Ile Leu 
            20                  25                  30          

Leu 
    

<210>   709
<211>   1304
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   709
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accttctaaa   180
attccttatc ttgaaacgac tggtatgcct actagaattc tccttagaaa gcgtcgattc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ctatcgtcaa gaaaaatcac   300
caaatccctc gtatcatcaa ccaaaagatt gctcaaaagt tgattgaaaa gatttctatg   360
actgatattg cccatcagct ttccatctca acttcaactg ttattcgtaa gctcaatgat   420
tttcacttta aacatgattt ttcttgtctt cctgagatta tgtcttggga tgagtatgct   480
tttacaaagg gaaagatgag cttcattgcg caagatttta acaatctcaa tatcatcact   540

gttcttgagg gtagaacaca agctatcatt cgaaatcact ttcttcgcta cgatagagtt   600
gtccgatgtc gcgtcaaaat tattactatg gatatgttta gcccttacta tgacttggct   660
aaacagcttc gctttcaaat tcctaggctc aggctgaaac agtctcccag actgtttcac   720
tcccgaatgc taaaatcgtt cttgatcgct ttcacattgt acaacatctt agccgtgcca   780
tgagtcgtgt gcgtgtccaa atcatgaatc agtttcatcg aaaatcccat gaatacaagg   840
atatcaagcg ctactggaaa ctcattcaac aggatagccg tagactgagt gataagcgat   900
tttatcgtcc tacttttcgt atgcacttaa ccaataaaga gattttagac aagcttttga   960
gccattcaca agacttgaaa caccactatc agctctatca gctcttgctg tttcacttcc   1020
agaataagga accagagaaa tttttcggac ttattgagga caatcttaag caggctcatc   1080
ctatttttca gactgtcttt aaaaccttcc tcaaagataa agaaaagatt gtcaacgccc   1140
ttcaactaca ctattctaat gccaaactgg aagcgaccaa taatctcatc aaacttatca   1200
agcgcaatgc ctttggtttt cgaaactttg aaaacttcaa aaaacggatt tttatcgctt   1260
tgaacatcaa aaaagaaagg acgaaatttg tcctttctcg agct                    1304

<210>   710
<211>   260
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase FRAMESHIFT

<400>   710
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ser 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Lys 
    130                 135                 140                 

His Asp Phe Ser Cys Leu Pro Glu Ile Met Ser Trp Asp Glu Tyr Ala 
145                 150                 155                 160 

Phe Thr Lys Gly Lys Met Ser Phe Ile Ala Gln Asp Phe Asn Asn Leu 
                165                 170                 175     

Asn Ile Ile Thr Val Leu Glu Gly Arg Thr Gln Ala Ile Ile Arg Asn 
            180                 185                 190         

His Phe Leu Arg Tyr Asp Arg Val Val Arg Cys Arg Val Lys Ile Ile 
        195                 200                 205             

Thr Met Asp Met Phe Ser Pro Tyr Tyr Asp Leu Ala Lys Gln Leu Arg 
    210                 215                 220                 

Phe Gln Ile Pro Arg Leu Arg Leu Lys Gln Ser Pro Arg Leu Phe His 
225                 230                 235                 240 

Ser Arg Met Leu Lys Ser Phe Leu Ile Ala Phe Thr Leu Tyr Asn Ile 
                245                 250                 255     

Leu Ala Val Pro 
            260 

<210>   711
<211>   525
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   711
atgagtcgtg tgcgtgtcca aatcatgaat cagtttcatc gaaaatccca tgaatacaag   60
gatatcaagc gctactggaa actcattcaa caggatagcc gtagactgag tgataagcga   120
ttttatcgtc ctacttttcg tatgcactta accaataaag agattttaga caagcttttg   180
agccattcac aagacttgaa acaccactat cagctctatc agctcttgct gtttcacttc   240
cagaataagg aaccagagaa atttttcgga cttattgagg acaatcttaa gcaggctcat   300
cctatttttc agactgtctt taaaaccttc ctcaaagata aagaaaagat tgtcaacgcc   360
cttcaactac actattctaa tgccaaactg gaagcgacca ataatctcat caaacttatc   420
aagcgcaatg cctttggttt tcgaaacttt gaaaacttca aaaaacggat ttttatcgct   480
ttgaacatca aaaaagaaag gacgaaattt gtcctttctc gagct                   525

<210>   712
<211>   175
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   712
Met Ser Arg Val Arg Val Gln Ile Met Asn Gln Phe His Arg Lys Ser 
1               5                   10                  15      

His Glu Tyr Lys Asp Ile Lys Arg Tyr Trp Lys Leu Ile Gln Gln Asp 
            20                  25                  30          

Ser Arg Arg Leu Ser Asp Lys Arg Phe Tyr Arg Pro Thr Phe Arg Met 
        35                  40                  45              

His Leu Thr Asn Lys Glu Ile Leu Asp Lys Leu Leu Ser His Ser Gln 

    50                  55                  60                  

Asp Leu Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu Phe His Phe 
65                  70                  75                  80  

Gln Asn Lys Glu Pro Glu Lys Phe Phe Gly Leu Ile Glu Asp Asn Leu 
                85                  90                  95      

Lys Gln Ala His Pro Ile Phe Gln Thr Val Phe Lys Thr Phe Leu Lys 
            100                 105                 110         

Asp Lys Glu Lys Ile Val Asn Ala Leu Gln Leu His Tyr Ser Asn Ala 
        115                 120                 125             

Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys Arg Asn Ala 
    130                 135                 140                 

Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile Phe Ile Ala 
145                 150                 155                 160 

Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser Arg Ala 
                165                 170                 175 

<210>   713
<211>   420

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   713
atgactagtc cactattaga atctagacgc caactccgta aatgcgcttt tcaagctctc   60
atgagccttg agttcggtac ggatgtcgaa actgcttgtc gtttcgccta tactcatgat   120
cgtgaagata cggatgtaca acttccagcc tttttgatag acctcgtttc tggtgttcaa   180
gctaaaaagg aagaactaga taagcaaatc actcagcatt taaaagcagg ttggaccatt   240
gaacgcttaa cgctcgtgga gagaaacctc cttcgcttgg gagtctttga aatcacttca   300
tttgacactc ctcagctggt tgctgttaat gaagctatcg agcttgcaaa ggacttctcc   360
gatcaaaaat ctgcccgttt tatcaatgga ctgctcagcc agtttgtaac agaagaacaa   420

<210>   714
<211>   140
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   N utilization substance protein B (nusB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902434 (1.E-75)

<400>   714
Met Thr Ser Pro Leu Leu Glu Ser Arg Arg Gln Leu Arg Lys Cys Ala 
1               5                   10                  15      

Phe Gln Ala Leu Met Ser Leu Glu Phe Gly Thr Asp Val Glu Thr Ala 
            20                  25                  30          

Cys Arg Phe Ala Tyr Thr His Asp Arg Glu Asp Thr Asp Val Gln Leu 
        35                  40                  45              

Pro Ala Phe Leu Ile Asp Leu Val Ser Gly Val Gln Ala Lys Lys Glu 
    50                  55                  60                  

Glu Leu Asp Lys Gln Ile Thr Gln His Leu Lys Ala Gly Trp Thr Ile 
65                  70                  75                  80  

Glu Arg Leu Thr Leu Val Glu Arg Asn Leu Leu Arg Leu Gly Val Phe 
                85                  90                  95      

Glu Ile Thr Ser Phe Asp Thr Pro Gln Leu Val Ala Val Asn Glu Ala 
            100                 105                 110         

Ile Glu Leu Ala Lys Asp Phe Ser Asp Gln Lys Ser Ala Arg Phe Ile 
        115                 120                 125             

Asn Gly Leu Leu Ser Gln Phe Val Thr Glu Glu Gln 
    130                 135                 140 

<210>   715
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   715
atgggaattg aagaacaact tggcgaaatc gttatcgccc cacgtgtact tgaaaaaatc   60
attgctatcg ctactgcaaa ggtagagggt gttcactctt tttcaaacag atcagtgtct   120
gatacccttt caaaactttc actcggccgt ggcatttatc ttaaaaacgt ggacgaagaa   180
ctcacagcag atatctatct ctaccttgag tacggagtaa aagttcctaa ggtagcggtt   240
gctatccaga aagctgtcaa agatgccgtc cgtaatatgg ctgatgtaga actcgctgct   300
atcaatattc acgttgcagg tatcgtccca gataaaacac caaaaccaga attgaaagat   360
ctatttgacg aggacttcct caatgac                                       387

<210>   716
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902435 (4.E-68)

<400>   716
Met Gly Ile Glu Glu Gln Leu Gly Glu Ile Val Ile Ala Pro Arg Val 
1               5                   10                  15      

Leu Glu Lys Ile Ile Ala Ile Ala Thr Ala Lys Val Glu Gly Val His 
            20                  25                  30          

Ser Phe Ser Asn Arg Ser Val Ser Asp Thr Leu Ser Lys Leu Ser Leu 
        35                  40                  45              

Gly Arg Gly Ile Tyr Leu Lys Asn Val Asp Glu Glu Leu Thr Ala Asp 
    50                  55                  60                  

Ile Tyr Leu Tyr Leu Glu Tyr Gly Val Lys Val Pro Lys Val Ala Val 
65                  70                  75                  80  

Ala Ile Gln Lys Ala Val Lys Asp Ala Val Arg Asn Met Ala Asp Val 
                85                  90                  95      

Glu Leu Ala Ala Ile Asn Ile His Val Ala Gly Ile Val Pro Asp Lys 
            100                 105                 110         

Thr Pro Lys Pro Glu Leu Lys Asp Leu Phe Asp Glu Asp Phe Leu Asn 
        115                 120                 125             

Asp 
    

<210>   717
<211>   558
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   717
atgattgaag caagtaaatt aaaagctggt atgacctttg aaacagctga cggcaaattg   60
attcgcgttt tggaagctag tcaccacaaa ccaggtaaag gaaacacgat catgcgtatg   120
aaattgcgtg atgtccgtac tggttctaca tttgacacaa gctaccgtcc agaggaaaaa   180
tttgaacaag ctattatcga gactgtccca gctcaatact tgtacaaaat ggatgacaca   240
gcatacttca tgaatacaga aacttatgac caatacgaaa tccctgtagt caatgttgaa   300
aacgaattgc tttacatcct tgaaaactct gatgtgaaaa tccaattcta cggaactgaa   360
gtgatcggtg tcaccgttcc tactactgtt gagttgacag ttgctgaaac tcaaccatct   420
atcaaaggtg ctactgttac aggttctggt aaaccagcaa cgatggaaac tggacttgtc   480
gtaaacgttc cagacttcat cgaagcagga caaaaactcg ttatcaacac tgcagaagga   540
acttacgttt ctcgtgcc                                                 558

<210>   718
<211>   186
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   translation elongation factor P (efp)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902436 (e-103)

<400>   718
Met Ile Glu Ala Ser Lys Leu Lys Ala Gly Met Thr Phe Glu Thr Ala 
1               5                   10                  15      

Asp Gly Lys Leu Ile Arg Val Leu Glu Ala Ser His His Lys Pro Gly 
            20                  25                  30          

Lys Gly Asn Thr Ile Met Arg Met Lys Leu Arg Asp Val Arg Thr Gly 
        35                  40                  45              

Ser Thr Phe Asp Thr Ser Tyr Arg Pro Glu Glu Lys Phe Glu Gln Ala 
    50                  55                  60                  

Ile Ile Glu Thr Val Pro Ala Gln Tyr Leu Tyr Lys Met Asp Asp Thr 
65                  70                  75                  80  

Ala Tyr Phe Met Asn Thr Glu Thr Tyr Asp Gln Tyr Glu Ile Pro Val 
                85                  90                  95      

Val Asn Val Glu Asn Glu Leu Leu Tyr Ile Leu Glu Asn Ser Asp Val 
            100                 105                 110         

Lys Ile Gln Phe Tyr Gly Thr Glu Val Ile Gly Val Thr Val Pro Thr 
        115                 120                 125             

Thr Val Glu Leu Thr Val Ala Glu Thr Gln Pro Ser Ile Lys Gly Ala 
    130                 135                 140                 

Thr Val Thr Gly Ser Gly Lys Pro Ala Thr Met Glu Thr Gly Leu Val 
145                 150                 155                 160 

Val Asn Val Pro Asp Phe Ile Glu Ala Gly Gln Lys Leu Val Ile Asn 
                165                 170                 175     

Thr Ala Glu Gly Thr Tyr Val Ser Arg Ala 
            180                 185     

<210>   719
<211>   1440
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   719
atgaactttg aaacagtcat cggacttgaa gtccacgtag agctcaacac caattcaaaa   60
atcttctcac ctacttctgc ccactttgga aatgaccaaa atgccaacac taacgtgatt   120
gactggtctt tcccaggagt tctaccagtt ctcaataaag gggttgttga tgccggtatc   180
aaggctgctc ttgccctcaa catggacatc cacaaaaaga tgcactttga ccgcaagaac   240
tacttctatc ctgataaccc caaagcctac caaatttctc agtttgatga accaatcgga   300
tataatggct ggattgaagt caaactagaa gacggtacga ccaagaaaat cggtatcgaa   360
cgtgcccacc tagaggaaga cgctggtaaa aacacccatg gtacagatgg ctactcttat   420
gttgacctca accgccaagg ggttcccttg attgagattg tatctgaggc agatatgcgt   480
tctcctgaag aagcctatgc ttatctgaca gccctcaagg aagttatcca gtacgctggc   540
atttctgacg ttaagatgga ggaaggttcg atgcgtgtgg atgccaacat ctcccttcgt   600
ccttatggtc aagagaaatt cggtaccaag actgaattga agaacctcaa ctccttctca   660
aacgttcgta aaggtcttga atacgaagtc caacgccagg ctgaaattct tcgctcaggt   720
ggtcaaatcc gccaagaaac acgccgttac gatgaagcga ataaagcaac catcctcatg   780
cgtgtcaagg aaggggctgc tgactaccgc tacttcccag aaccagacct acccctcttt   840
gaaatttctg acgagtggat tgaggaaatg cggactgagt tgccagagtt tccaaaagaa   900

cgtcgtgcgc gttatgtatc tgaccttggt ttatcagact acgatgctag tcagttgact   960
gctaataaag tcacttctga cttctttgaa aaagctgttg ccctaggtgg tgatgccaaa   1020
caagtctcta actggctcca aggggaagtc gctcagttct tgaatgctga aggtaaaaca   1080
ctggaacaaa tcgaattgac accagaaaac ttggttgaaa tgattgccat catcgaagac   1140
ggtactattt catctaagat tgccaagaaa gtctttgtcc atctagctaa aaatggcggt   1200
ggcgcgcgtg aatacgtgga aaaagcaggt atggttcaaa tttcagatcc agctatcttg   1260
atcccaatca tccaccaagt ctttgccgat aacgaagctg ctgttgccga cttcaagtca   1320
ggcaaacgta acgccgacaa ggcctttaca ggattcctta tgaaggcaac caaaggccaa   1380
gccaacccac aagttgccct taaactactt gcacaggaat tggcgaagtt gaaagaaaac   1440

<210>   720
<211>   480
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamyl-tRNA(Gln) amidotransferase subunit B (gatB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902437 (0.E+01)

<400>   720
Met Asn Phe Glu Thr Val Ile Gly Leu Glu Val His Val Glu Leu Asn 
1               5                   10                  15      

Thr Asn Ser Lys Ile Phe Ser Pro Thr Ser Ala His Phe Gly Asn Asp 
            20                  25                  30          

Gln Asn Ala Asn Thr Asn Val Ile Asp Trp Ser Phe Pro Gly Val Leu 
        35                  40                  45              

Pro Val Leu Asn Lys Gly Val Val Asp Ala Gly Ile Lys Ala Ala Leu 
    50                  55                  60                  

Ala Leu Asn Met Asp Ile His Lys Lys Met His Phe Asp Arg Lys Asn 
65                  70                  75                  80  

Tyr Phe Tyr Pro Asp Asn Pro Lys Ala Tyr Gln Ile Ser Gln Phe Asp 
                85                  90                  95      

Glu Pro Ile Gly Tyr Asn Gly Trp Ile Glu Val Lys Leu Glu Asp Gly 
            100                 105                 110         

Thr Thr Lys Lys Ile Gly Ile Glu Arg Ala His Leu Glu Glu Asp Ala 
        115                 120                 125             

Gly Lys Asn Thr His Gly Thr Asp Gly Tyr Ser Tyr Val Asp Leu Asn 
    130                 135                 140                 

Arg Gln Gly Val Pro Leu Ile Glu Ile Val Ser Glu Ala Asp Met Arg 
145                 150                 155                 160 

Ser Pro Glu Glu Ala Tyr Ala Tyr Leu Thr Ala Leu Lys Glu Val Ile 
                165                 170                 175     

Gln Tyr Ala Gly Ile Ser Asp Val Lys Met Glu Glu Gly Ser Met Arg 
            180                 185                 190         

Val Asp Ala Asn Ile Ser Leu Arg Pro Tyr Gly Gln Glu Lys Phe Gly 
        195                 200                 205             

Thr Lys Thr Glu Leu Lys Asn Leu Asn Ser Phe Ser Asn Val Arg Lys 
    210                 215                 220                 

Gly Leu Glu Tyr Glu Val Gln Arg Gln Ala Glu Ile Leu Arg Ser Gly 
225                 230                 235                 240 

Gly Gln Ile Arg Gln Glu Thr Arg Arg Tyr Asp Glu Ala Asn Lys Ala 
                245                 250                 255     

Thr Ile Leu Met Arg Val Lys Glu Gly Ala Ala Asp Tyr Arg Tyr Phe 
            260                 265                 270         

Pro Glu Pro Asp Leu Pro Leu Phe Glu Ile Ser Asp Glu Trp Ile Glu 
        275                 280                 285             

Glu Met Arg Thr Glu Leu Pro Glu Phe Pro Lys Glu Arg Arg Ala Arg 
    290                 295                 300                 

Tyr Val Ser Asp Leu Gly Leu Ser Asp Tyr Asp Ala Ser Gln Leu Thr 
305                 310                 315                 320 

Ala Asn Lys Val Thr Ser Asp Phe Phe Glu Lys Ala Val Ala Leu Gly 
                325                 330                 335     

Gly Asp Ala Lys Gln Val Ser Asn Trp Leu Gln Gly Glu Val Ala Gln 
            340                 345                 350         

Phe Leu Asn Ala Glu Gly Lys Thr Leu Glu Gln Ile Glu Leu Thr Pro 

        355                 360                 365             

Glu Asn Leu Val Glu Met Ile Ala Ile Ile Glu Asp Gly Thr Ile Ser 
    370                 375                 380                 

Ser Lys Ile Ala Lys Lys Val Phe Val His Leu Ala Lys Asn Gly Gly 
385                 390                 395                 400 

Gly Ala Arg Glu Tyr Val Glu Lys Ala Gly Met Val Gln Ile Ser Asp 
                405                 410                 415     

Pro Ala Ile Leu Ile Pro Ile Ile His Gln Val Phe Ala Asp Asn Glu 
            420                 425                 430         

Ala Ala Val Ala Asp Phe Lys Ser Gly Lys Arg Asn Ala Asp Lys Ala 
        435                 440                 445             

Phe Thr Gly Phe Leu Met Lys Ala Thr Lys Gly Gln Ala Asn Pro Gln 
    450                 455                 460                 

Val Ala Leu Lys Leu Leu Ala Gln Glu Leu Ala Lys Leu Lys Glu Asn 
465                 470                 475                 480 


<210>   721
<211>   1464
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   721
atgactttta acaataaaac tattgaagag ttgcacaatc tccttgtctc taaggaaatt   60
tctgcaacag aattgaccca agcaacactt gaaaatatca agtctcgtga ggaagccctc   120
aattcatttg tcaccatcgc tgaggagcaa gctcttgttc aagctaaagc cattgatgaa   180
gctggaattg atgctgacaa tgtcctttca ggaattccac ttgctgttaa ggataacatc   240
tctacagacg gtattctcac aactgctgcc tcaaaaatgc tctacaacta tgagccaatc   300
tttgatgcga cagctgttgc caatgcaaaa accaagggca tgattgtcgt tggaaagacc   360
aacatggacg aatttgctat gggtggttca ggtgaaactt cacactacgg agcaactaaa   420
aacgcttgga accacagcaa ggttcctggt gggtcatcaa gtggttctgc cgcagctgta   480
gcctcaggac aagttcgctt gtcacttggt tctgatactg gtggttccat ccgccaacct   540
gctgccttca acggaatcgt tggtctcaaa ccaacctacg gaacagtttc acgtttcggt   600
ctcattgcct ttggtagctc attagaccag attggacctt ttgctcctac tgttaaggaa   660
aatgccctct tgctcaacgc tattgccagc gaagatgcta aagactctac ttctgctcct   720
gtccgcatcg ccgactttac ttcaaaaatc ggccaagaca tcaagggtat gaaaatcgct   780
ttgcctaagg aatacctagg cgaaggaatt gatccagagg ttaaggaaac aatcttaaac   840
gcggccaaac actttgaaaa attgggtgct atcgtcgaag aagtcagcct tcctcactct   900
aaatacggtg ttgccgttta ttacatcatc gcttcatcag aagcttcatc aaacttgcaa   960
cgcttcgacg gtatccgtta cggctatcgc gcagaagatg caaccaacct tgatgaaatc   1020
tatgtaaaca gccgaagcca aggttttggt gaagaggtaa aacgtcgtat catgctgggt   1080
actttcagtc tttcatcagg ttactatgat gcctactaca aaaaggctgg tcaagtccgt   1140
accctcatca ttcaagattt cgaaaaagtc ttcgcggatt acgatttgat tttgggtcca   1200

actgctccaa gtgttgccta tgacttggat tctctcaacc atgacccagt tgccatgtac   1260
ttagccgacc tattgaccat acctgtaaac ttggcaggac tgcctggaat ttcgattcct   1320
gctggattct ctcaaggtct acctgtcgga ctccaattga ttggtcccaa gtactctgag   1380
gaaaccattt accaagctgc tgctgctttt gaagcaacaa cagactacca caaacaacaa   1440
cccgtgattt ttggaggtga caac                                          1464

<210>   722
<211>   488
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamyl-tRNA(Gln) amidotransferase subunit A (gatA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902438 (0.E+01)

<400>   722
Met Thr Phe Asn Asn Lys Thr Ile Glu Glu Leu His Asn Leu Leu Val 
1               5                   10                  15      

Ser Lys Glu Ile Ser Ala Thr Glu Leu Thr Gln Ala Thr Leu Glu Asn 
            20                  25                  30          

Ile Lys Ser Arg Glu Glu Ala Leu Asn Ser Phe Val Thr Ile Ala Glu 
        35                  40                  45              

Glu Gln Ala Leu Val Gln Ala Lys Ala Ile Asp Glu Ala Gly Ile Asp 
    50                  55                  60                  

Ala Asp Asn Val Leu Ser Gly Ile Pro Leu Ala Val Lys Asp Asn Ile 
65                  70                  75                  80  

Ser Thr Asp Gly Ile Leu Thr Thr Ala Ala Ser Lys Met Leu Tyr Asn 
                85                  90                  95      

Tyr Glu Pro Ile Phe Asp Ala Thr Ala Val Ala Asn Ala Lys Thr Lys 
            100                 105                 110         

Gly Met Ile Val Val Gly Lys Thr Asn Met Asp Glu Phe Ala Met Gly 
        115                 120                 125             

Gly Ser Gly Glu Thr Ser His Tyr Gly Ala Thr Lys Asn Ala Trp Asn 
    130                 135                 140                 

His Ser Lys Val Pro Gly Gly Ser Ser Ser Gly Ser Ala Ala Ala Val 
145                 150                 155                 160 

Ala Ser Gly Gln Val Arg Leu Ser Leu Gly Ser Asp Thr Gly Gly Ser 
                165                 170                 175     

Ile Arg Gln Pro Ala Ala Phe Asn Gly Ile Val Gly Leu Lys Pro Thr 
            180                 185                 190         

Tyr Gly Thr Val Ser Arg Phe Gly Leu Ile Ala Phe Gly Ser Ser Leu 
        195                 200                 205             

Asp Gln Ile Gly Pro Phe Ala Pro Thr Val Lys Glu Asn Ala Leu Leu 
    210                 215                 220                 

Leu Asn Ala Ile Ala Ser Glu Asp Ala Lys Asp Ser Thr Ser Ala Pro 
225                 230                 235                 240 

Val Arg Ile Ala Asp Phe Thr Ser Lys Ile Gly Gln Asp Ile Lys Gly 
                245                 250                 255     

Met Lys Ile Ala Leu Pro Lys Glu Tyr Leu Gly Glu Gly Ile Asp Pro 
            260                 265                 270         

Glu Val Lys Glu Thr Ile Leu Asn Ala Ala Lys His Phe Glu Lys Leu 
        275                 280                 285             

Gly Ala Ile Val Glu Glu Val Ser Leu Pro His Ser Lys Tyr Gly Val 
    290                 295                 300                 

Ala Val Tyr Tyr Ile Ile Ala Ser Ser Glu Ala Ser Ser Asn Leu Gln 
305                 310                 315                 320 

Arg Phe Asp Gly Ile Arg Tyr Gly Tyr Arg Ala Glu Asp Ala Thr Asn 
                325                 330                 335     

Leu Asp Glu Ile Tyr Val Asn Ser Arg Ser Gln Gly Phe Gly Glu Glu 
            340                 345                 350         

Val Lys Arg Arg Ile Met Leu Gly Thr Phe Ser Leu Ser Ser Gly Tyr 
        355                 360                 365             

Tyr Asp Ala Tyr Tyr Lys Lys Ala Gly Gln Val Arg Thr Leu Ile Ile 
    370                 375                 380                 

Gln Asp Phe Glu Lys Val Phe Ala Asp Tyr Asp Leu Ile Leu Gly Pro 
385                 390                 395                 400 

Thr Ala Pro Ser Val Ala Tyr Asp Leu Asp Ser Leu Asn His Asp Pro 
                405                 410                 415     

Val Ala Met Tyr Leu Ala Asp Leu Leu Thr Ile Pro Val Asn Leu Ala 
            420                 425                 430         

Gly Leu Pro Gly Ile Ser Ile Pro Ala Gly Phe Ser Gln Gly Leu Pro 
        435                 440                 445             

Val Gly Leu Gln Leu Ile Gly Pro Lys Tyr Ser Glu Glu Thr Ile Tyr 
    450                 455                 460                 

Gln Ala Ala Ala Ala Phe Glu Ala Thr Thr Asp Tyr His Lys Gln Gln 
465                 470                 475                 480 

Pro Val Ile Phe Gly Gly Asp Asn 
                485             

<210>   723
<211>   300
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   723
atgaaaatta cgcaagaaga ggtaacacac gttgccaatc tttcaaaatt aagattctct   60
gaagaagaaa ctgctgcctt tgcgaccacc ttgtctaaga ttgttgacat ggttgaattg   120
ctgggcgaag ttgacacaac tggtgtcgca cctactacga ctatggctga ccgcaagact   180
gtactccgcc ctgatgtggc cgaagaagga atagaccgtg atcgcttgtt taaaaacgta   240
cctgaaaaag acaactacta tatcaaggtg ccagctatcc tagacaatgg aggagatgcc   300

<210>   724
<211>   100
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamyl-tRNA(Gln) amidotransferase subunit C (gatC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902439 (4.E-51)

<400>   724
Met Lys Ile Thr Gln Glu Glu Val Thr His Val Ala Asn Leu Ser Lys 
1               5                   10                  15      

Leu Arg Phe Ser Glu Glu Glu Thr Ala Ala Phe Ala Thr Thr Leu Ser 
            20                  25                  30          

Lys Ile Val Asp Met Val Glu Leu Leu Gly Glu Val Asp Thr Thr Gly 
        35                  40                  45              

Val Ala Pro Thr Thr Thr Met Ala Asp Arg Lys Thr Val Leu Arg Pro 
    50                  55                  60                  

Asp Val Ala Glu Glu Gly Ile Asp Arg Asp Arg Leu Phe Lys Asn Val 
65                  70                  75                  80  

Pro Glu Lys Asp Asn Tyr Tyr Ile Lys Val Pro Ala Ile Leu Asp Asn 
                85                  90                  95      

Gly Gly Asp Ala 
            100 

<210>   725
<211>   1542
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   725
atgaatattc aagaagaaat taagaaacgt cgtacctttg ccattatctc ccacccggac   60
gcggggaaaa caaccatcac tgagcagtta ctctactttg ggggtgagat tcgtgaggct   120
ggtacggtaa aagggaagaa aacagggact tttgctaaat ctgactggat ggatatcgag   180
aagcaacgtg ggatttctgt tacttcatct gttatgcaat ttgactacga cggcaagcgc   240
gtgaatatct tagacacgcc agggcacgag gacttctcag aagataccta tcgtaccttg   300
atggcggtgg atgctgcggt catggtcgtg gactctgcca aggggatcga ggctcaaacc   360
aagaaattgt ttgaggttgt gaaacatcgt ggcattccag tctttacctt tatgaacaag   420
ctggaccgtg acggtcgtga gcctttggat ctcttgcaag aattggaaga aatcttgggc   480
attgctagct accctatgaa ctggcctatc gggatgggga aagcctttga gggcttgtat   540
gacctctata accaacgttt agagctttac aaaggggatg agcgttttgc cagtctagaa   600
gacggggaca aactctttgg tagcaatcct ttctacgagc aagtcaagga tgacattgag   660
cttttaaatg aagccgggaa tgagttttca gaggaagcta ttctggctgg agaattgacg   720
cctgtctttt tcggttcagc cctgacaaac tttggtgtgc agaccttcct tgaaaccttc   780
ctcaagtttg ctccagaacc acatggtcac aagaaaacag acggtgaaat tgtggatcct   840
tatgacaagg atttctcagg ctttgtcttt aaaatccaag ccaacatgga ccctcgtcac   900
cgtgaccgta ttgcctttgt ccgtatcgta tctggcgaat ttgagcgcgg catgagtgtc   960
aatctccctc gtactggtaa gggggctaaa ctatctaatg ttacccagtt tatggcggag   1020
agtcgtgaga atgtgaccaa tgccgtggca ggtgatatta tcggggttta cgataccggt   1080
acttatcagg ttggggatac cttgacggtt ggaaaaaaca agtttgaatt tgaacccctg   1140
ccaaccttta cacctgagat tttcatgaaa gtttctgcta agaatgttat gaagcaaaaa   1200
tccttccaca aggggattga gcaattggtg caagaaggag ccgttcagct ttataagaat   1260
taccaaacag gtgagtacat gctaggcgct gtaggtcaac tccagtttga agtctttaaa   1320
caccgcatgg aaggcgagta caatgcggaa gtagttatga acccaatggg taaaaagacc   1380
gttcgttgga tcaagcctga ggacttggat gaacggatgt cgtcaagtcg caatatctta   1440
gccaaagacc gttttgacca accagtcttt ctctttgaaa atgactttgc cctccgctgg   1500
tttgcggaca agtatccaga cgtagagtta gaggagaaga tg                      1542

<210>   726
<211>   514
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptide chain release factor 3 (prfC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902440 (0.E+01)

<400>   726
Met Asn Ile Gln Glu Glu Ile Lys Lys Arg Arg Thr Phe Ala Ile Ile 
1               5                   10                  15      

Ser His Pro Asp Ala Gly Lys Thr Thr Ile Thr Glu Gln Leu Leu Tyr 
            20                  25                  30          

Phe Gly Gly Glu Ile Arg Glu Ala Gly Thr Val Lys Gly Lys Lys Thr 
        35                  40                  45              

Gly Thr Phe Ala Lys Ser Asp Trp Met Asp Ile Glu Lys Gln Arg Gly 
    50                  55                  60                  

Ile Ser Val Thr Ser Ser Val Met Gln Phe Asp Tyr Asp Gly Lys Arg 
65                  70                  75                  80  

Val Asn Ile Leu Asp Thr Pro Gly His Glu Asp Phe Ser Glu Asp Thr 
                85                  90                  95      

Tyr Arg Thr Leu Met Ala Val Asp Ala Ala Val Met Val Val Asp Ser 
            100                 105                 110         

Ala Lys Gly Ile Glu Ala Gln Thr Lys Lys Leu Phe Glu Val Val Lys 
        115                 120                 125             

His Arg Gly Ile Pro Val Phe Thr Phe Met Asn Lys Leu Asp Arg Asp 
    130                 135                 140                 

Gly Arg Glu Pro Leu Asp Leu Leu Gln Glu Leu Glu Glu Ile Leu Gly 
145                 150                 155                 160 

Ile Ala Ser Tyr Pro Met Asn Trp Pro Ile Gly Met Gly Lys Ala Phe 
                165                 170                 175     

Glu Gly Leu Tyr Asp Leu Tyr Asn Gln Arg Leu Glu Leu Tyr Lys Gly 
            180                 185                 190         

Asp Glu Arg Phe Ala Ser Leu Glu Asp Gly Asp Lys Leu Phe Gly Ser 
        195                 200                 205             

Asn Pro Phe Tyr Glu Gln Val Lys Asp Asp Ile Glu Leu Leu Asn Glu 
    210                 215                 220                 

Ala Gly Asn Glu Phe Ser Glu Glu Ala Ile Leu Ala Gly Glu Leu Thr 
225                 230                 235                 240 

Pro Val Phe Phe Gly Ser Ala Leu Thr Asn Phe Gly Val Gln Thr Phe 
                245                 250                 255     

Leu Glu Thr Phe Leu Lys Phe Ala Pro Glu Pro His Gly His Lys Lys 
            260                 265                 270         


Thr Asp Gly Glu Ile Val Asp Pro Tyr Asp Lys Asp Phe Ser Gly Phe 
        275                 280                 285             

Val Phe Lys Ile Gln Ala Asn Met Asp Pro Arg His Arg Asp Arg Ile 
    290                 295                 300                 

Ala Phe Val Arg Ile Val Ser Gly Glu Phe Glu Arg Gly Met Ser Val 
305                 310                 315                 320 

Asn Leu Pro Arg Thr Gly Lys Gly Ala Lys Leu Ser Asn Val Thr Gln 
                325                 330                 335     

Phe Met Ala Glu Ser Arg Glu Asn Val Thr Asn Ala Val Ala Gly Asp 
            340                 345                 350         

Ile Ile Gly Val Tyr Asp Thr Gly Thr Tyr Gln Val Gly Asp Thr Leu 
        355                 360                 365             

Thr Val Gly Lys Asn Lys Phe Glu Phe Glu Pro Leu Pro Thr Phe Thr 
    370                 375                 380                 

Pro Glu Ile Phe Met Lys Val Ser Ala Lys Asn Val Met Lys Gln Lys 
385                 390                 395                 400 

Ser Phe His Lys Gly Ile Glu Gln Leu Val Gln Glu Gly Ala Val Gln 
                405                 410                 415     

Leu Tyr Lys Asn Tyr Gln Thr Gly Glu Tyr Met Leu Gly Ala Val Gly 
            420                 425                 430         

Gln Leu Gln Phe Glu Val Phe Lys His Arg Met Glu Gly Glu Tyr Asn 
        435                 440                 445             

Ala Glu Val Val Met Asn Pro Met Gly Lys Lys Thr Val Arg Trp Ile 
    450                 455                 460                 

Lys Pro Glu Asp Leu Asp Glu Arg Met Ser Ser Ser Arg Asn Ile Leu 
465                 470                 475                 480 

Ala Lys Asp Arg Phe Asp Gln Pro Val Phe Leu Phe Glu Asn Asp Phe 
                485                 490                 495     

Ala Leu Arg Trp Phe Ala Asp Lys Tyr Pro Asp Val Glu Leu Glu Glu 
            500                 505                 510         

Lys Met 
        

<210>   727
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   727
gtgaaagaag agaaaaaagc gattgtctta ggtgcagata atgcttatat ggataaagtt   60
gaaacaacaa taaaatctct ttgtgttcat cattataatc ttaagtttta tgtttttaat   120
gatgaccttc cgcgagaatg gttccaattg atggaaaaaa gactagagac tttgaatagt   180
gagattgtga atgtt                                                    195

<210>   728
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, POINT MUTATION, FRAMESHIFT

<400>   728
Met Lys Glu Glu Lys Lys Ala Ile Val Leu Gly Ala Asp Asn Ala Tyr 
1               5                   10                  15      

Met Asp Lys Val Glu Thr Thr Ile Lys Ser Leu Cys Val His His Tyr 
            20                  25                  30          

Asn Leu Lys Phe Tyr Val Phe Asn Asp Asp Leu Pro Arg Glu Trp Phe 
        35                  40                  45              

Gln Leu Met Glu Lys Arg Leu Glu Thr Leu Asn Ser Glu Ile Val Asn 
    50                  55                  60                  

Val 
65  

<210>   729
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   729
ttggacttga cggctatacc cttagctgca gttagagatg atttttatac acataatttt   60
aattctggtg ttctgttaat caacgatggc atgtggagag cagaaaatgt cacgcaagac   120
ctgatt                                                              126

<210>   730
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   730
Met Asp Leu Thr Ala Ile Pro Leu Ala Ala Val Arg Asp Asp Phe Tyr 
1               5                   10                  15      

Thr His Asn Phe Asn Ser Gly Val Leu Leu Ile Asn Asp Gly Met Trp 
            20                  25                  30          

Arg Ala Glu Asn Val Thr Gln Asp Leu Ile 
        35                  40          

<210>   731
<211>   186
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   731
atggctaaag tatgttactt tacaggtcgt aagactgtat caggaaacaa ccgttcacac   60
gcgatgaacc aaacaaaacg tgccgtaaaa ccaaaccttc aaaaagttac tgttcttatc   120
gatggtaaac ctaaaaaagt ttgggcttca gctcgtgctt tgaaatcagg taaagttgaa   180
cgcgtt                                                              186

<210>   732
<211>   62
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L28 (rpmB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902442 (9.E-32)

<400>   732
Met Ala Lys Val Cys Tyr Phe Thr Gly Arg Lys Thr Val Ser Gly Asn 
1               5                   10                  15      

Asn Arg Ser His Ala Met Asn Gln Thr Lys Arg Ala Val Lys Pro Asn 
            20                  25                  30          

Leu Gln Lys Val Thr Val Leu Ile Asp Gly Lys Pro Lys Lys Val Trp 
        35                  40                  45              

Ala Ser Ala Arg Ala Leu Lys Ser Gly Lys Val Glu Arg Val 
    50                  55                  60          

<210>   733
<211>   363
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   733
atgactgtaa aaattaatac aaaagatggt caaatcgaac taacagatga agtgattgca   60
accgtcgtag gtggagcagc aactgagatt tttggtgtgg tcggtatggc tagtaaaaat   120
gccctcaaag ataatttcca agccctgcta ggtaaggaaa attattctaa aggtgtcgtc   180
gtaaaggcag ccgaagatgg cagtattgca gttgatgtat ataccgtgtt aagctacgga   240
acaaagatta gtgaagtgtc aaaaaacatt caagagcgtg ttgcctttag cttggaaaac   300
cagcttggaa ttactgctca gactgtaaat gtctacattc aaaatatcaa agttgtagga   360
gaa                                                                 363

<210>   734
<211>   121
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   conserved hypothetical protein (Alkaline shock protein)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902443 (9.E-62)

<400>   734
Met Thr Val Lys Ile Asn Thr Lys Asp Gly Gln Ile Glu Leu Thr Asp 
1               5                   10                  15      

Glu Val Ile Ala Thr Val Val Gly Gly Ala Ala Thr Glu Ile Phe Gly 
            20                  25                  30          

Val Val Gly Met Ala Ser Lys Asn Ala Leu Lys Asp Asn Phe Gln Ala 
        35                  40                  45              

Leu Leu Gly Lys Glu Asn Tyr Ser Lys Gly Val Val Val Lys Ala Ala 
    50                  55                  60                  

Glu Asp Gly Ser Ile Ala Val Asp Val Tyr Thr Val Leu Ser Tyr Gly 
65                  70                  75                  80  

Thr Lys Ile Ser Glu Val Ser Lys Asn Ile Gln Glu Arg Val Ala Phe 
                85                  90                  95      

Ser Leu Glu Asn Gln Leu Gly Ile Thr Ala Gln Thr Val Asn Val Tyr 
            100                 105                 110         

Ile Gln Asn Ile Lys Val Val Gly Glu 
        115                 120     

<210>   735
<211>   1665
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   735
gtgtcaaaaa ttactactag cttatttcaa gaaatggtgc aggctgcatc aactcgcttg   60
aataagcaag ctgaatatgt caattcatta aacgtctttc cagttccaga tggagatact   120
gggacaaata tgggaatgac cattgaaaat ggtgctaaag aagttgcaga caagccagct   180
tctacagttg gagaagtagc gagcattctt gccaaagggc ttttgatggg tgcgcgtggg   240
aactcaggag tgattacgtc tcagcttttc cgtggatttt cccaagctat caaggataaa   300
gacgagttaa caggtcaaga cttggctctg gccttccaat caggtgtgga agttgcctat   360
aaggcagtga tgaaacctgt tgaaggaacg attttaacag tttctcgtgg agctgctatc   420
ggtgctaaga aaaaagctga gcaaacagat gacgctgttg aagtcatgcg cgcagccttg   480
gaaggtgcta aaacagctct agctaaaaca ccagacatgc ttccagtatt gaaagaagtt   540
ggcgttgtgg actcaggtgg tcaaggattg gtcttcatct acgaaggttt cctttcagcc   600
cttactggcg aatatattgc atctgaggac tttgtagcga ctcctgccaa catgagtgag   660
atgatcaatg tagagcatca taagtctgta gctggtcacg tagcgactga ggacatcacg   720
tttggttact gtactgaaat catggtagct cttaagcaag gtccaaccta tgctaaagat   780
tttgactacg atgaattccg taactacttg gatgagcttg gagattctct ccttgttgtt   840
aacgatgatg aaattgtcaa agtccatgtt catacagaag atccaggact tgttatgcaa   900
gaaggtctca aatatggtag cttggtcaag gtaaaagttg acaatatgcg taaccaacac   960
gaagcacagg ttgagaaaga agctactcaa gttatcaagt cggctgaaga aaaagagtat   1020
gctttgattg ctgtggtggc tggtaaaggt ctagcagata tcttctgttc tcaaggcgtg   1080
gattatgtta tcgaaggcgg tcaaaccatg aacccttcaa cagaagactt tatcaaggct   1140
gttgaacagg ttaatgcccg taacatcatc ttcttgccaa acaacaagaa catcttcatg   1200
gcagctcaat ctgcggcaga agttttggag caaccagcgg tagtggtaga ggctcgcact   1260
cttcctcaag gtatgacaag tcttcttgcc tttgatccaa gcaagtccat tgaagaaaac   1320
caagagcgta tgacagctgc tcttagcgat gtcgttagcg gaagcgtcac aacagccgtg   1380
cgtgatacaa cgatcgatgg cttagaaatc catgaaaacg ataatttagg tatggtggat   1440
ggaaaaattc ttgtgtcaaa ccctgatatg caccaaacat tgactgaaac cttgaaacat   1500
atgttggatg aagacagtga aatcgtaacc ttctatgtag gtgaagacgg aagcgaagaa   1560
cttgccaatg aaatcgctca agaaatcgta gaagaattcg aagacgttga agtcgagatt   1620
caccaaggtc aacaacctgt ttacccatac ctatttagtg tggaa                   1665

<210>   736
<211>   555
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902444 (0.E+01)

<400>   736
Met Ser Lys Ile Thr Thr Ser Leu Phe Gln Glu Met Val Gln Ala Ala 
1               5                   10                  15      

Ser Thr Arg Leu Asn Lys Gln Ala Glu Tyr Val Asn Ser Leu Asn Val 
            20                  25                  30          

Phe Pro Val Pro Asp Gly Asp Thr Gly Thr Asn Met Gly Met Thr Ile 
        35                  40                  45              

Glu Asn Gly Ala Lys Glu Val Ala Asp Lys Pro Ala Ser Thr Val Gly 
    50                  55                  60                  

Glu Val Ala Ser Ile Leu Ala Lys Gly Leu Leu Met Gly Ala Arg Gly 
65                  70                  75                  80  

Asn Ser Gly Val Ile Thr Ser Gln Leu Phe Arg Gly Phe Ser Gln Ala 
                85                  90                  95      

Ile Lys Asp Lys Asp Glu Leu Thr Gly Gln Asp Leu Ala Leu Ala Phe 
            100                 105                 110         

Gln Ser Gly Val Glu Val Ala Tyr Lys Ala Val Met Lys Pro Val Glu 
        115                 120                 125             

Gly Thr Ile Leu Thr Val Ser Arg Gly Ala Ala Ile Gly Ala Lys Lys 
    130                 135                 140                 

Lys Ala Glu Gln Thr Asp Asp Ala Val Glu Val Met Arg Ala Ala Leu 
145                 150                 155                 160 

Glu Gly Ala Lys Thr Ala Leu Ala Lys Thr Pro Asp Met Leu Pro Val 
                165                 170                 175     

Leu Lys Glu Val Gly Val Val Asp Ser Gly Gly Gln Gly Leu Val Phe 
            180                 185                 190         

Ile Tyr Glu Gly Phe Leu Ser Ala Leu Thr Gly Glu Tyr Ile Ala Ser 
        195                 200                 205             

Glu Asp Phe Val Ala Thr Pro Ala Asn Met Ser Glu Met Ile Asn Val 
    210                 215                 220                 

Glu His His Lys Ser Val Ala Gly His Val Ala Thr Glu Asp Ile Thr 
225                 230                 235                 240 

Phe Gly Tyr Cys Thr Glu Ile Met Val Ala Leu Lys Gln Gly Pro Thr 
                245                 250                 255     

Tyr Ala Lys Asp Phe Asp Tyr Asp Glu Phe Arg Asn Tyr Leu Asp Glu 
            260                 265                 270         


Leu Gly Asp Ser Leu Leu Val Val Asn Asp Asp Glu Ile Val Lys Val 
        275                 280                 285             

His Val His Thr Glu Asp Pro Gly Leu Val Met Gln Glu Gly Leu Lys 
    290                 295                 300                 

Tyr Gly Ser Leu Val Lys Val Lys Val Asp Asn Met Arg Asn Gln His 
305                 310                 315                 320 

Glu Ala Gln Val Glu Lys Glu Ala Thr Gln Val Ile Lys Ser Ala Glu 
                325                 330                 335     

Glu Lys Glu Tyr Ala Leu Ile Ala Val Val Ala Gly Lys Gly Leu Ala 
            340                 345                 350         

Asp Ile Phe Cys Ser Gln Gly Val Asp Tyr Val Ile Glu Gly Gly Gln 
        355                 360                 365             

Thr Met Asn Pro Ser Thr Glu Asp Phe Ile Lys Ala Val Glu Gln Val 
    370                 375                 380                 

Asn Ala Arg Asn Ile Ile Phe Leu Pro Asn Asn Lys Asn Ile Phe Met 
385                 390                 395                 400 

Ala Ala Gln Ser Ala Ala Glu Val Leu Glu Gln Pro Ala Val Val Val 
                405                 410                 415     

Glu Ala Arg Thr Leu Pro Gln Gly Met Thr Ser Leu Leu Ala Phe Asp 
            420                 425                 430         

Pro Ser Lys Ser Ile Glu Glu Asn Gln Glu Arg Met Thr Ala Ala Leu 
        435                 440                 445             

Ser Asp Val Val Ser Gly Ser Val Thr Thr Ala Val Arg Asp Thr Thr 
    450                 455                 460                 

Ile Asp Gly Leu Glu Ile His Glu Asn Asp Asn Leu Gly Met Val Asp 
465                 470                 475                 480 

Gly Lys Ile Leu Val Ser Asn Pro Asp Met His Gln Thr Leu Thr Glu 
                485                 490                 495     

Thr Leu Lys His Met Leu Asp Glu Asp Ser Glu Ile Val Thr Phe Tyr 
            500                 505                 510         

Val Gly Glu Asp Gly Ser Glu Glu Leu Ala Asn Glu Ile Ala Gln Glu 
        515                 520                 525             

Ile Val Glu Glu Phe Glu Asp Val Glu Val Glu Ile His Gln Gly Gln 
    530                 535                 540                 

Gln Pro Val Tyr Pro Tyr Leu Phe Ser Val Glu 
545                 550                 555 

<210>   737
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   737
atgaatgtta tttttgtttt tattaaaaag ataccgattt catttactaa aaagaaaaaa   60
gaactgattt ctcagtcctt cattaatctt attccacac                          99

<210>   738
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   738
Met Asn Val Ile Phe Val Phe Ile Lys Lys Ile Pro Ile Ser Phe Thr 
1               5                   10                  15      

Lys Lys Lys Lys Glu Leu Ile Ser Gln Ser Phe Ile Asn Leu Ile Pro 
            20                  25                  30          

His 
    

<210>   739
<211>   1698
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   739
atggagaaaa tcagtttaga atctcctaag acggggtcgg acctagtttt ggaaacactt   60
cgtgatttag gagttgatac catctttggt tatcctggtg gtgcggtttt gcctttttat   120
gatgcgatat ataattttaa aggcattcgc cacattctag ggcgccatga gcaaggttgt   180
ttgcatgaag ctgaaggtta tgccaaatca actggaaagt tgggtgttgc cgtcgtcact   240
agtggaccag gagcaacaaa tgccattaca gggattgcgg atgccatgag cgatagcgtt   300
ccccttttgg tctttacagg tcaggtggcg cgagcaggga ttgggaagga tgcctttcag   360
gaggcagaca tcgtgggaat taccatgcca atcactaagt acaattacca agttcgtgag   420
acagctgata ttccgcgtat cattacggaa gctgtccata tcgcaactac aggccgtcca   480
gggccagttg taattgacct accaaaagac atatctgctt tagaaacaga cttcatttat   540
tcaccagaag tgaatttacc aagttatcag ccgactcttg agccgaatga tatgcaaatc   600
aagaaaatct tgaagcaatt gtccaaggct aaaaagccag tcttgttagc tggtggtgga   660
attagttatg ctgaggctgc tacggaacta aatgaatttg cagaacgcta tcaaattcca   720
gtggtaacca gtcttttggg acaaggaacg attgcaacga gtcacccact ctttcttgga   780
atgggaggca tgcacgggtc attcgcagca aatattgcta tgacggaagc ggactttatg   840
attagtattg gttctcgttt cgatgaccgt ttgacgggga atcctaagac tttcgctaag   900
aatgctaagg ttgcccacat tgatattgac ccagctgaga ttggcaagat tatcagtgca   960
gacattcctg tagttggaga tgctaagaag gccttgcaaa tgttgctagc agaaccaaca   1020
gttcacaaca acactgaaaa gtggattgag aaagtcacta aagacaagaa tcgtgttcgt   1080
tcttatgata agaaagagcg tgtggttcaa ccgcaagcag ttattgaacg aattggtgaa   1140
ttgacgaatg gagatgccat tgtggtaaca gacgttggtc aacaccaaat gtggacagct   1200
cagtattatc cctaccaaaa tgaacgtcag ttagtgactt caggtggttt gggaacaatg   1260
ggctttggaa ttccagcagc aatcggtgct aaaattgcta acccagataa ggaagtagtc   1320
ttgtttgttg gggatggtgg tttccaaatg accaaccagg agttggctat tttgaatatt   1380
tacaaggtgc caatcaaggt ggttatgctg aacaatcatt cacttggaat ggttcgccag   1440
tggcaggaat ccttctatga aggcagaaca tcagagtcgg tctttgatac ccttcctgat   1500
ttccaattga tggcgcaggc ttatggtatt aaaaactata agtttgacaa tcctgagacc   1560
ttggctcaag accttgaagt catcactgag gatgttccta tgctaattga ggtagatatt   1620
tctcgtaagg aacaggtgtt accaatggta ccggctggta agagtaatca tgagatgttg   1680
ggggtgcagt tccatgcg                                                 1698

<210>   740
<211>   566
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetolactate synthase, large subunit (ilvB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902445 (0.E+01)

<400>   740
Met Glu Lys Ile Ser Leu Glu Ser Pro Lys Thr Gly Ser Asp Leu Val 
1               5                   10                  15      

Leu Glu Thr Leu Arg Asp Leu Gly Val Asp Thr Ile Phe Gly Tyr Pro 
            20                  25                  30          

Gly Gly Ala Val Leu Pro Phe Tyr Asp Ala Ile Tyr Asn Phe Lys Gly 
        35                  40                  45              

Ile Arg His Ile Leu Gly Arg His Glu Gln Gly Cys Leu His Glu Ala 
    50                  55                  60                  

Glu Gly Tyr Ala Lys Ser Thr Gly Lys Leu Gly Val Ala Val Val Thr 
65                  70                  75                  80  

Ser Gly Pro Gly Ala Thr Asn Ala Ile Thr Gly Ile Ala Asp Ala Met 
                85                  90                  95      

Ser Asp Ser Val Pro Leu Leu Val Phe Thr Gly Gln Val Ala Arg Ala 
            100                 105                 110         

Gly Ile Gly Lys Asp Ala Phe Gln Glu Ala Asp Ile Val Gly Ile Thr 
        115                 120                 125             

Met Pro Ile Thr Lys Tyr Asn Tyr Gln Val Arg Glu Thr Ala Asp Ile 
    130                 135                 140                 

Pro Arg Ile Ile Thr Glu Ala Val His Ile Ala Thr Thr Gly Arg Pro 
145                 150                 155                 160 

Gly Pro Val Val Ile Asp Leu Pro Lys Asp Ile Ser Ala Leu Glu Thr 
                165                 170                 175     

Asp Phe Ile Tyr Ser Pro Glu Val Asn Leu Pro Ser Tyr Gln Pro Thr 
            180                 185                 190         

Leu Glu Pro Asn Asp Met Gln Ile Lys Lys Ile Leu Lys Gln Leu Ser 
        195                 200                 205             

Lys Ala Lys Lys Pro Val Leu Leu Ala Gly Gly Gly Ile Ser Tyr Ala 
    210                 215                 220                 

Glu Ala Ala Thr Glu Leu Asn Glu Phe Ala Glu Arg Tyr Gln Ile Pro 
225                 230                 235                 240 

Val Val Thr Ser Leu Leu Gly Gln Gly Thr Ile Ala Thr Ser His Pro 
                245                 250                 255     

Leu Phe Leu Gly Met Gly Gly Met His Gly Ser Phe Ala Ala Asn Ile 
            260                 265                 270         

Ala Met Thr Glu Ala Asp Phe Met Ile Ser Ile Gly Ser Arg Phe Asp 
        275                 280                 285             

Asp Arg Leu Thr Gly Asn Pro Lys Thr Phe Ala Lys Asn Ala Lys Val 
    290                 295                 300                 

Ala His Ile Asp Ile Asp Pro Ala Glu Ile Gly Lys Ile Ile Ser Ala 
305                 310                 315                 320 

Asp Ile Pro Val Val Gly Asp Ala Lys Lys Ala Leu Gln Met Leu Leu 
                325                 330                 335     

Ala Glu Pro Thr Val His Asn Asn Thr Glu Lys Trp Ile Glu Lys Val 
            340                 345                 350         

Thr Lys Asp Lys Asn Arg Val Arg Ser Tyr Asp Lys Lys Glu Arg Val 
        355                 360                 365             

Val Gln Pro Gln Ala Val Ile Glu Arg Ile Gly Glu Leu Thr Asn Gly 
    370                 375                 380                 

Asp Ala Ile Val Val Thr Asp Val Gly Gln His Gln Met Trp Thr Ala 
385                 390                 395                 400 

Gln Tyr Tyr Pro Tyr Gln Asn Glu Arg Gln Leu Val Thr Ser Gly Gly 
                405                 410                 415     

Leu Gly Thr Met Gly Phe Gly Ile Pro Ala Ala Ile Gly Ala Lys Ile 
            420                 425                 430         

Ala Asn Pro Asp Lys Glu Val Val Leu Phe Val Gly Asp Gly Gly Phe 
        435                 440                 445             

Gln Met Thr Asn Gln Glu Leu Ala Ile Leu Asn Ile Tyr Lys Val Pro 
    450                 455                 460                 

Ile Lys Val Val Met Leu Asn Asn His Ser Leu Gly Met Val Arg Gln 
465                 470                 475                 480 

Trp Gln Glu Ser Phe Tyr Glu Gly Arg Thr Ser Glu Ser Val Phe Asp 
                485                 490                 495     

Thr Leu Pro Asp Phe Gln Leu Met Ala Gln Ala Tyr Gly Ile Lys Asn 
            500                 505                 510         

Tyr Lys Phe Asp Asn Pro Glu Thr Leu Ala Gln Asp Leu Glu Val Ile 
        515                 520                 525             

Thr Glu Asp Val Pro Met Leu Ile Glu Val Asp Ile Ser Arg Lys Glu 
    530                 535                 540                 

Gln Val Leu Pro Met Val Pro Ala Gly Lys Ser Asn His Glu Met Leu 
545                 550                 555                 560 

Gly Val Gln Phe His Ala 
                565     

<210>   741
<211>   474
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   741
atgcgtagaa tgttaacagc aaaactacaa aatcgttcag gagtcctcaa tcgctttaca   60
ggtgtcctat ctcgtcgtca ggttaatatt gaaagcatct ctgttggagc aacagaagat   120
ccgaatgtat cgcgtatcac tattattatt gatgttgctt ctcatgatga agtggagcaa   180
atcatcaaac agctcaatcg tcagattgat gtgattcgca ttcgagatat tacagacaag   240
cctcatttgg agcgcgaggt gattttggtt aagatgtcag cgccagctga gaagagagct   300
gagattttag cgattattca acctttccgt gcaacagtag tagacgtagc gccaagctcg   360
attaccattc agatgacggg aaatgcagaa aagagcgaag ccctattgcg agtcattcgc   420
ccatacggta ttcgcaatat tgctcgaacg ggtgcaactg gatttacccg cgat         474

<210>   742
<211>   158
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetolactate synthase small subunit
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902446 (3.E-83)

<400>   742
Met Arg Arg Met Leu Thr Ala Lys Leu Gln Asn Arg Ser Gly Val Leu 

1               5                   10                  15      

Asn Arg Phe Thr Gly Val Leu Ser Arg Arg Gln Val Asn Ile Glu Ser 
            20                  25                  30          

Ile Ser Val Gly Ala Thr Glu Asp Pro Asn Val Ser Arg Ile Thr Ile 
        35                  40                  45              

Ile Ile Asp Val Ala Ser His Asp Glu Val Glu Gln Ile Ile Lys Gln 
    50                  55                  60                  

Leu Asn Arg Gln Ile Asp Val Ile Arg Ile Arg Asp Ile Thr Asp Lys 
65                  70                  75                  80  

Pro His Leu Glu Arg Glu Val Ile Leu Val Lys Met Ser Ala Pro Ala 
                85                  90                  95      

Glu Lys Arg Ala Glu Ile Leu Ala Ile Ile Gln Pro Phe Arg Ala Thr 
            100                 105                 110         

Val Val Asp Val Ala Pro Ser Ser Ile Thr Ile Gln Met Thr Gly Asn 
        115                 120                 125             

Ala Glu Lys Ser Glu Ala Leu Leu Arg Val Ile Arg Pro Tyr Gly Ile 
    130                 135                 140                 

Arg Asn Ile Ala Arg Thr Gly Ala Thr Gly Phe Thr Arg Asp 
145                 150                 155             

<210>   743
<211>   1020
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   743
atgacagttc aaatggaata tgaaaaagat gttaaagtag cagcacttga cggtaaaaaa   60
atcgccgtta tcggttatgg ttcacaaggg catgcgcatg ctcaaaactt gcgtgattca   120
ggtcgtgacg ttattatcgg tgtacgtcca ggtaaatctt ttgataaagc aaaagaagat   180
ggatttgata cttacacagt agcagaagct actaagttgg ctgatgttat catgatcttg   240
gcgccagacg aaattcaaca agaattgtac gaagcagaaa tcgctccaaa cttggaagct   300
ggaaacgcag ttggatttgc ccatggtttc aacatccact ttgaatttat caaagttcct   360
gcggatgtag atgtcttcat gtgtgctcct aaaggaccag gacacttggt acgtcgtact   420
tacgaagaag gatttggtgt tccagctctt tatgcagtat accaagatgc aacaggaaat   480
gctaaaaaca ttgctatgga ctggtgtaaa ggtgttggag cggctcgtgt aggtcttctt   540
gaaacaactt acaaagaaga aactgaagaa gatttgtttg gtgaacaagc tgtactttgt   600
ggtggtttga ctgcccttat cgaagcaggt ttcgaagtct tgacagaagc aggttacgct   660
ccagaattgg cttactttga agttcttcac gaaatgaaat tgatcgttga cttgatctac   720
gaaggtggat tcaagaaaat gcgtcaatct atttcaaaca ctgctgaata cggtgactat   780
gtatcaggtc cacgtgtaat cactgaacaa gttaaagaaa atatgaaggc tgtcttggca   840
gacatccaaa atggtaaatt tgcaaatgac tttgtaaatg actataaagc tggacgtcca   900
aaattgactg cttaccgtga acaagcagct aaccttgaaa ttgaaaaagt tggtgcagaa   960
ttgcgtaaag caatgccatt cgttggtaaa aacgacgatg atgcattcaa aatctataac   1020

<210>   744
<211>   340
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ketol-acid reductoisomerase (ilvC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902447 (0.E+01)

<400>   744
Met Thr Val Gln Met Glu Tyr Glu Lys Asp Val Lys Val Ala Ala Leu 
1               5                   10                  15      

Asp Gly Lys Lys Ile Ala Val Ile Gly Tyr Gly Ser Gln Gly His Ala 
            20                  25                  30          

His Ala Gln Asn Leu Arg Asp Ser Gly Arg Asp Val Ile Ile Gly Val 
        35                  40                  45              

Arg Pro Gly Lys Ser Phe Asp Lys Ala Lys Glu Asp Gly Phe Asp Thr 
    50                  55                  60                  

Tyr Thr Val Ala Glu Ala Thr Lys Leu Ala Asp Val Ile Met Ile Leu 
65                  70                  75                  80  

Ala Pro Asp Glu Ile Gln Gln Glu Leu Tyr Glu Ala Glu Ile Ala Pro 
                85                  90                  95      

Asn Leu Glu Ala Gly Asn Ala Val Gly Phe Ala His Gly Phe Asn Ile 
            100                 105                 110         

His Phe Glu Phe Ile Lys Val Pro Ala Asp Val Asp Val Phe Met Cys 
        115                 120                 125             

Ala Pro Lys Gly Pro Gly His Leu Val Arg Arg Thr Tyr Glu Glu Gly 
    130                 135                 140                 

Phe Gly Val Pro Ala Leu Tyr Ala Val Tyr Gln Asp Ala Thr Gly Asn 
145                 150                 155                 160 

Ala Lys Asn Ile Ala Met Asp Trp Cys Lys Gly Val Gly Ala Ala Arg 
                165                 170                 175     

Val Gly Leu Leu Glu Thr Thr Tyr Lys Glu Glu Thr Glu Glu Asp Leu 
            180                 185                 190         

Phe Gly Glu Gln Ala Val Leu Cys Gly Gly Leu Thr Ala Leu Ile Glu 
        195                 200                 205             

Ala Gly Phe Glu Val Leu Thr Glu Ala Gly Tyr Ala Pro Glu Leu Ala 
    210                 215                 220                 

Tyr Phe Glu Val Leu His Glu Met Lys Leu Ile Val Asp Leu Ile Tyr 
225                 230                 235                 240 

Glu Gly Gly Phe Lys Lys Met Arg Gln Ser Ile Ser Asn Thr Ala Glu 
                245                 250                 255     

Tyr Gly Asp Tyr Val Ser Gly Pro Arg Val Ile Thr Glu Gln Val Lys 
            260                 265                 270         

Glu Asn Met Lys Ala Val Leu Ala Asp Ile Gln Asn Gly Lys Phe Ala 
        275                 280                 285             

Asn Asp Phe Val Asn Asp Tyr Lys Ala Gly Arg Pro Lys Leu Thr Ala 
    290                 295                 300                 

Tyr Arg Glu Gln Ala Ala Asn Leu Glu Ile Glu Lys Val Gly Ala Glu 
305                 310                 315                 320 

Leu Arg Lys Ala Met Pro Phe Val Gly Lys Asn Asp Asp Asp Ala Phe 
                325                 330                 335     

Lys Ile Tyr Asn 
            340 

<210>   745
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   745
ttgtataatg taattacacc gtcggtaata gtgctagcag accaaaataa agcagattgg   60
tcgtatgatg aaaatgctgt aattaacatt tatgatgatg ctaattttga agatggtagg   120
ttgcatatga actttgaaca attcttcaaa ttggcacaaa tagctagaga agaaggtctt   180
gaaattcatt ctccgtttga gagagctggt gcgactaaat ctgctcgtta tatagcgaaa   240
tggattttga gaaataaaaa acat                                          264

<210>   746
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902448 (3.E-47)

<400>   746
Met Tyr Asn Val Ile Thr Pro Ser Val Ile Val Leu Ala Asp Gln Asn 
1               5                   10                  15      

Lys Ala Asp Trp Ser Tyr Asp Glu Asn Ala Val Ile Asn Ile Tyr Asp 
            20                  25                  30          

Asp Ala Asn Phe Glu Asp Gly Arg Leu His Met Asn Phe Glu Gln Phe 
        35                  40                  45              

Phe Lys Leu Ala Gln Ile Ala Arg Glu Glu Gly Leu Glu Ile His Ser 
    50                  55                  60                  

Pro Phe Glu Arg Ala Gly Ala Thr Lys Ser Ala Arg Tyr Ile Ala Lys 
65                  70                  75                  80  

Trp Ile Leu Arg Asn Lys Lys His 
                85              

<210>   747
<211>   354
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   747
atgaatatta ccaatttgtt ttctatcaag acaggatgtg atgaaactga taggcaactg   60
caaaaactat tttttcagtt ggatttacaa ttgggagaat tgacagatca actaagaaaa   120
ttagattcta attttgttcc tcgtagtcaa tttgtagaca cgttggattt gaatgatgta   180
gaatataaag aaattttaaa ctattttatc ttccatcgta atgatagtga agaaagtttg   240
gtagaatggt tatatgattg gatttccaca aatcgttatg aacttcctaa agagttttcg   300
attcgtatgg ctcataaata ccatgaaagt gttactgaag ttttcggaga tgaa         354

<210>   748
<211>   118
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902449 (1.E-66)

<400>   748
Met Asn Ile Thr Asn Leu Phe Ser Ile Lys Thr Gly Cys Asp Glu Thr 
1               5                   10                  15      

Asp Arg Gln Leu Gln Lys Leu Phe Phe Gln Leu Asp Leu Gln Leu Gly 
            20                  25                  30          

Glu Leu Thr Asp Gln Leu Arg Lys Leu Asp Ser Asn Phe Val Pro Arg 
        35                  40                  45              

Ser Gln Phe Val Asp Thr Leu Asp Leu Asn Asp Val Glu Tyr Lys Glu 
    50                  55                  60                  

Ile Leu Asn Tyr Phe Ile Phe His Arg Asn Asp Ser Glu Glu Ser Leu 
65                  70                  75                  80  

Val Glu Trp Leu Tyr Asp Trp Ile Ser Thr Asn Arg Tyr Glu Leu Pro 
                85                  90                  95      

Lys Glu Phe Ser Ile Arg Met Ala His Lys Tyr His Glu Ser Val Thr 
            100                 105                 110         

Glu Val Phe Gly Asp Glu 
        115             

<210>   749
<211>   1248
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   749
atgttaagtt caaaagatat aatcaaggct cacaaggtct tgaacggtgt ggttgtgaat   60
actccactgg attacgatca ttatttatcg gagaagtatg gtgctaagat ttatttgaaa   120
aaagaaaatg cccagcgtgt tcgctccttt aaaattcgtg gtgcctatta tgccatttcc   180
cagctcagca aggaagaacg tgaacgtggg gtagtctgcg cttctgcggg aaatcatgcg   240
cagggagtag cctatacttg taatgaaatg aaaattcctg ctactatctt tatgcccatt   300
actacgccac aacaaaagat tggtcaggtt cgcttttttg gtggggattt tgtaactatt   360
aaactagttg gagatacctt tgatgcctca gccaaagcag ctcaagaatt tacagtctct   420
gaaaatcgta cctttattga tccttttgat gatgctcatg ttcaagcagg tcaaggaaca   480
gttgcttatg agattttaga agaagctcga aaagaatcga ttgattttga tgctgtcttg   540
gttcctgttg gtggtggcgg tctcattgcc ggggtttcta cctatatcaa ggaaacaagt   600
ccagagattg aggttatcgg agtagaggcg aatggagcgc gttccatgaa agctgccttt   660
gaggctggag gtccagtaaa actcaaggaa attgataaat ttgctgatgg gattgctgtg   720
caaaaggtag gtcagttgac ctatgaagca actcgtcaac atattaaaac tttggtaggt   780
gtcgatgagg gattgatttc tgaaaccttg attgaccttt actctaagca agggatagtc   840
gcagaacctg ctggagcggc tagtatcgcc tctttagagg ttttagctga atatattaag   900
gggaaaacca tttgttgtat catttctgga ggaaataatg atatcaaccg tatgccagaa   960
atggaagagc gtgccttgat ttatgatggt atcaaacatt actttgtggt caatttccca   1020
caacgtccag gagctttgcg tgagtttgta aatgatatcc tggggccaaa tgatgatatc   1080
acacgttttg agtatatcaa acgagctagc aagggaacag gcccagtatt aattgggatc   1140
gctttagcag ataagcatga ttatgcaggt ttgattcgta gaatggaagg ttttgatcca   1200
gcttatatta acttaaatgg taatgaaacg ctttataata tgcttgtc                1248

<210>   750
<211>   416
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   threonine dehydratase (ilvA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902450 (0.E+01)

<400>   750
Met Leu Ser Ser Lys Asp Ile Ile Lys Ala His Lys Val Leu Asn Gly 
1               5                   10                  15      

Val Val Val Asn Thr Pro Leu Asp Tyr Asp His Tyr Leu Ser Glu Lys 
            20                  25                  30          

Tyr Gly Ala Lys Ile Tyr Leu Lys Lys Glu Asn Ala Gln Arg Val Arg 
        35                  40                  45              

Ser Phe Lys Ile Arg Gly Ala Tyr Tyr Ala Ile Ser Gln Leu Ser Lys 
    50                  55                  60                  

Glu Glu Arg Glu Arg Gly Val Val Cys Ala Ser Ala Gly Asn His Ala 
65                  70                  75                  80  

Gln Gly Val Ala Tyr Thr Cys Asn Glu Met Lys Ile Pro Ala Thr Ile 
                85                  90                  95      

Phe Met Pro Ile Thr Thr Pro Gln Gln Lys Ile Gly Gln Val Arg Phe 
            100                 105                 110         

Phe Gly Gly Asp Phe Val Thr Ile Lys Leu Val Gly Asp Thr Phe Asp 
        115                 120                 125             

Ala Ser Ala Lys Ala Ala Gln Glu Phe Thr Val Ser Glu Asn Arg Thr 
    130                 135                 140                 

Phe Ile Asp Pro Phe Asp Asp Ala His Val Gln Ala Gly Gln Gly Thr 
145                 150                 155                 160 

Val Ala Tyr Glu Ile Leu Glu Glu Ala Arg Lys Glu Ser Ile Asp Phe 
                165                 170                 175     

Asp Ala Val Leu Val Pro Val Gly Gly Gly Gly Leu Ile Ala Gly Val 
            180                 185                 190         

Ser Thr Tyr Ile Lys Glu Thr Ser Pro Glu Ile Glu Val Ile Gly Val 
        195                 200                 205             

Glu Ala Asn Gly Ala Arg Ser Met Lys Ala Ala Phe Glu Ala Gly Gly 
    210                 215                 220                 

Pro Val Lys Leu Lys Glu Ile Asp Lys Phe Ala Asp Gly Ile Ala Val 
225                 230                 235                 240 

Gln Lys Val Gly Gln Leu Thr Tyr Glu Ala Thr Arg Gln His Ile Lys 
                245                 250                 255     

Thr Leu Val Gly Val Asp Glu Gly Leu Ile Ser Glu Thr Leu Ile Asp 
            260                 265                 270         

Leu Tyr Ser Lys Gln Gly Ile Val Ala Glu Pro Ala Gly Ala Ala Ser 
        275                 280                 285             

Ile Ala Ser Leu Glu Val Leu Ala Glu Tyr Ile Lys Gly Lys Thr Ile 
    290                 295                 300                 

Cys Cys Ile Ile Ser Gly Gly Asn Asn Asp Ile Asn Arg Met Pro Glu 
305                 310                 315                 320 

Met Glu Glu Arg Ala Leu Ile Tyr Asp Gly Ile Lys His Tyr Phe Val 
                325                 330                 335     

Val Asn Phe Pro Gln Arg Pro Gly Ala Leu Arg Glu Phe Val Asn Asp 
            340                 345                 350         

Ile Leu Gly Pro Asn Asp Asp Ile Thr Arg Phe Glu Tyr Ile Lys Arg 
        355                 360                 365             

Ala Ser Lys Gly Thr Gly Pro Val Leu Ile Gly Ile Ala Leu Ala Asp 
    370                 375                 380                 

Lys His Asp Tyr Ala Gly Leu Ile Arg Arg Met Glu Gly Phe Asp Pro 
385                 390                 395                 400 

Ala Tyr Ile Asn Leu Asn Gly Asn Glu Thr Leu Tyr Asn Met Leu Val 
                405                 410                 415     


<210>   751
<211>   213

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   751
atggctaagt caaactttga aaaagtagaa tcagttgttg gctgggttcg tgataagaaa   60
atcacaggct accgtatctc taaagaaacg aatgcgcgtg aaatgtctat cattgctctg   120
gcgcagggtc gtgcaaaagt aaaaaatatt tcatttgaaa cagccctagg cctaattgat   180
ttctatgaaa aaaattatga aaaatttgaa gat                                213

<210>   752
<211>   71
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902451 (3.E-36)

<400>   752
Met Ala Lys Ser Asn Phe Glu Lys Val Glu Ser Val Val Gly Trp Val 
1               5                   10                  15      

Arg Asp Lys Lys Ile Thr Gly Tyr Arg Ile Ser Lys Glu Thr Asn Ala 
            20                  25                  30          

Arg Glu Met Ser Ile Ile Ala Leu Ala Gln Gly Arg Ala Lys Val Lys 
        35                  40                  45              

Asn Ile Ser Phe Glu Thr Ala Leu Gly Leu Ile Asp Phe Tyr Glu Lys 
    50                  55                  60                  

Asn Tyr Glu Lys Phe Glu Asp 
65                  70      

<210>   753
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   753
atgacacaag caatccttga aattaaacac ctcaaaaaat cctatggaca aaacgaagtg   60
ctaaaagaca tttcactcac tgtccacaag ggagaggtca tctctatcat cggaagctct   120
ggaagcggaa aatcgacctt cctacgctcc attaacctac ttgaaacacc aactgatgga   180
caaatccttt atcatggaca aaacgtcctc gaaaaaggct atgacctcac gcaataccgt   240
gaaaagttgg ggatggtttt ccaatccttt aacctctttg aaaatctcaa tgttcttgaa   300
aacacaatcg tcgctcagac aactgtccta aaacgcgaac gcacagaagc tgaaaagatt   360
gccaaagaaa acctggaaaa ggtcggcatg ggagaacgct actggcaagc caaaccaaaa   420
caactctcag gtggtcaaaa acaacgtgtg gccatcgctc gtgccctctc catgaatccg   480
gacgctattc tctttgatga accaacatca gctctcgatc cagaaatggt tggagaagtc   540
ctcaaaatca tgcaggacct ggctcaggaa ggcttgacca tgattgtcgt aacccatgaa   600
atggaatttg cccgtgatgt ctctcaccgt gttatcttta tggataaggg cgtgatcgct   660
gaagaaggta aaccagaaga cctcttcacc aatcctaaag aagaccgaac aaaagagttc   720
cttcaacgct atctcaaa                                                 738

<210>   754
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902452 (e-138)

<400>   754
Met Thr Gln Ala Ile Leu Glu Ile Lys His Leu Lys Lys Ser Tyr Gly 
1               5                   10                  15      

Gln Asn Glu Val Leu Lys Asp Ile Ser Leu Thr Val His Lys Gly Glu 
            20                  25                  30          

Val Ile Ser Ile Ile Gly Ser Ser Gly Ser Gly Lys Ser Thr Phe Leu 
        35                  40                  45              

Arg Ser Ile Asn Leu Leu Glu Thr Pro Thr Asp Gly Gln Ile Leu Tyr 
    50                  55                  60                  

His Gly Gln Asn Val Leu Glu Lys Gly Tyr Asp Leu Thr Gln Tyr Arg 
65                  70                  75                  80  

Glu Lys Leu Gly Met Val Phe Gln Ser Phe Asn Leu Phe Glu Asn Leu 
                85                  90                  95      

Asn Val Leu Glu Asn Thr Ile Val Ala Gln Thr Thr Val Leu Lys Arg 
            100                 105                 110         

Glu Arg Thr Glu Ala Glu Lys Ile Ala Lys Glu Asn Leu Glu Lys Val 
        115                 120                 125             

Gly Met Gly Glu Arg Tyr Trp Gln Ala Lys Pro Lys Gln Leu Ser Gly 
    130                 135                 140                 

Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ser Met Asn Pro 
145                 150                 155                 160 

Asp Ala Ile Leu Phe Asp Glu Pro Thr Ser Ala Leu Asp Pro Glu Met 
                165                 170                 175     

Val Gly Glu Val Leu Lys Ile Met Gln Asp Leu Ala Gln Glu Gly Leu 
            180                 185                 190         

Thr Met Ile Val Val Thr His Glu Met Glu Phe Ala Arg Asp Val Ser 
        195                 200                 205             

His Arg Val Ile Phe Met Asp Lys Gly Val Ile Ala Glu Glu Gly Lys 
    210                 215                 220                 

Pro Glu Asp Leu Phe Thr Asn Pro Lys Glu Asp Arg Thr Lys Glu Phe 
225                 230                 235                 240 

Leu Gln Arg Tyr Leu Lys 
                245     

<210>   755
<211>   1563
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   755
atgagaaaaa tatacttatc tattttcaca agtctcttgc tgatgctagg acttgtcaat   60
gttgctcaag ccgatgaata tttacgcatc ggtatggaag cagcatatgc tccctttaac   120
tggacccagg atgatgatag caacggagct gtcaaaatcg atgggaccaa tcagtatgcc   180
aacggatacg atgttcaaat cgccaagaaa atcgctaagg acttaggtaa agaacctttg   240
gttgttaaaa ccaagtggga aggtctagtc cctgccctta cttctggtaa gattgacatg   300
attatcgcag gtatgagtcc aactgcagaa cgcaaacaag aaattgcctt ttcgagcagt   360
tactatacta gcgaaccagt tttgcttgtc aaaaaagatt ctgcctacgc aagtgctaaa   420
tctttggatg actttaacgg tgcaaaaatc acttctcaac aaggggtcta cctttataac   480
ttgattgcac aaatcccagg tgctaaaaaa gaaacagcca tgggagactt cgctcaaatg   540
cgacaagctc ttgaggctgg tgtcattgat gcttatgttt ctgaacgtcc agaagcactg   600
actgctgaag ctgcgaactc taagttcaag atgattcaag tagaacctgg tttcaaaact   660
ggggaagaag atacagctat cgctatcggg cttcgtaaaa atgacaatcg tattagccaa   720
atcaatgcca gcattgaaac catttcaaaa gatgaccaag ttgccttgat ggatcgtatg   780
atcaaggaac aacctgccga agctacaaca actgaagaga ctagcagtag tttctttagc   840
caagttgcta aaattctttc tgaaaactgg caacaactct tgcgtggtgc tggtatcact   900
cttttaatct ctatcgtcgg aaccatcata ggtctcatta ttggacttgc cattggtgtc   960
ttccgtactg ctcctctctc tgaaaacaaa gtcatttacg gcctacaaaa actagtcggc   1020
tgggttctca atgtctacat tgaaattttc cgtggtacgc caatgattgt tcaatcgatg   1080
gttatctact atggaactgc ccaagctttc gggatcaacc ttgaccgtac actggctgct   1140
atcttcatcg tttcaatcaa taccggtgcc tacatgactg aaatcgtccg tggtggtatc   1200
ctagcagttg acaagggaca atttgaagct gcgactgctc ttggtatgac ccataaccag   1260
accatgcgta agattgtcct acctcaggta gtccgtaaca tcctacctgc aactggtaat   1320
gaatttgtca tcaatatcaa agatacatct gtattgaacg ttatctctgt tgtcgaactt   1380
tatttctcag gaaataccgt ggcaacacaa acctatcaat acttccagac atttacaatc   1440
atcgccgtga tttactttgt cctcaccttc accgtaacac gtatcctacg ctttatcgag   1500
cgcagaatgg acatggatac ctacactaca ggtgctaacc aaatgcaaac ggaggatttg   1560
aaa                                                                 1563

<210>   756
<211>   521
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, amino acid-binding protein/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902453 (e-172)

<400>   756
Met Arg Lys Ile Tyr Leu Ser Ile Phe Thr Ser Leu Leu Leu Met Leu 
1               5                   10                  15      

Gly Leu Val Asn Val Ala Gln Ala Asp Glu Tyr Leu Arg Ile Gly Met 
            20                  25                  30          

Glu Ala Ala Tyr Ala Pro Phe Asn Trp Thr Gln Asp Asp Asp Ser Asn 
        35                  40                  45              

Gly Ala Val Lys Ile Asp Gly Thr Asn Gln Tyr Ala Asn Gly Tyr Asp 
    50                  55                  60                  

Val Gln Ile Ala Lys Lys Ile Ala Lys Asp Leu Gly Lys Glu Pro Leu 
65                  70                  75                  80  

Val Val Lys Thr Lys Trp Glu Gly Leu Val Pro Ala Leu Thr Ser Gly 
                85                  90                  95      

Lys Ile Asp Met Ile Ile Ala Gly Met Ser Pro Thr Ala Glu Arg Lys 
            100                 105                 110         

Gln Glu Ile Ala Phe Ser Ser Ser Tyr Tyr Thr Ser Glu Pro Val Leu 
        115                 120                 125             

Leu Val Lys Lys Asp Ser Ala Tyr Ala Ser Ala Lys Ser Leu Asp Asp 
    130                 135                 140                 

Phe Asn Gly Ala Lys Ile Thr Ser Gln Gln Gly Val Tyr Leu Tyr Asn 
145                 150                 155                 160 

Leu Ile Ala Gln Ile Pro Gly Ala Lys Lys Glu Thr Ala Met Gly Asp 
                165                 170                 175     

Phe Ala Gln Met Arg Gln Ala Leu Glu Ala Gly Val Ile Asp Ala Tyr 
            180                 185                 190         

Val Ser Glu Arg Pro Glu Ala Leu Thr Ala Glu Ala Ala Asn Ser Lys 
        195                 200                 205             

Phe Lys Met Ile Gln Val Glu Pro Gly Phe Lys Thr Gly Glu Glu Asp 
    210                 215                 220                 

Thr Ala Ile Ala Ile Gly Leu Arg Lys Asn Asp Asn Arg Ile Ser Gln 
225                 230                 235                 240 

Ile Asn Ala Ser Ile Glu Thr Ile Ser Lys Asp Asp Gln Val Ala Leu 
                245                 250                 255     

Met Asp Arg Met Ile Lys Glu Gln Pro Ala Glu Ala Thr Thr Thr Glu 
            260                 265                 270         

Glu Thr Ser Ser Ser Phe Phe Ser Gln Val Ala Lys Ile Leu Ser Glu 
        275                 280                 285             

Asn Trp Gln Gln Leu Leu Arg Gly Ala Gly Ile Thr Leu Leu Ile Ser 
    290                 295                 300                 

Ile Val Gly Thr Ile Ile Gly Leu Ile Ile Gly Leu Ala Ile Gly Val 
305                 310                 315                 320 

Phe Arg Thr Ala Pro Leu Ser Glu Asn Lys Val Ile Tyr Gly Leu Gln 
                325                 330                 335     

Lys Leu Val Gly Trp Val Leu Asn Val Tyr Ile Glu Ile Phe Arg Gly 
            340                 345                 350         

Thr Pro Met Ile Val Gln Ser Met Val Ile Tyr Tyr Gly Thr Ala Gln 
        355                 360                 365             

Ala Phe Gly Ile Asn Leu Asp Arg Thr Leu Ala Ala Ile Phe Ile Val 
    370                 375                 380                 

Ser Ile Asn Thr Gly Ala Tyr Met Thr Glu Ile Val Arg Gly Gly Ile 
385                 390                 395                 400 

Leu Ala Val Asp Lys Gly Gln Phe Glu Ala Ala Thr Ala Leu Gly Met 
                405                 410                 415     

Thr His Asn Gln Thr Met Arg Lys Ile Val Leu Pro Gln Val Val Arg 
            420                 425                 430         

Asn Ile Leu Pro Ala Thr Gly Asn Glu Phe Val Ile Asn Ile Lys Asp 
        435                 440                 445             

Thr Ser Val Leu Asn Val Ile Ser Val Val Glu Leu Tyr Phe Ser Gly 
    450                 455                 460                 

Asn Thr Val Ala Thr Gln Thr Tyr Gln Tyr Phe Gln Thr Phe Thr Ile 
465                 470                 475                 480 

Ile Ala Val Ile Tyr Phe Val Leu Thr Phe Thr Val Thr Arg Ile Leu 
                485                 490                 495     

Arg Phe Ile Glu Arg Arg Met Asp Met Asp Thr Tyr Thr Thr Gly Ala 
            500                 505                 510         

Asn Gln Met Gln Thr Glu Asp Leu Lys 
        515                 520     

<210>   757
<211>   1890
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   757
ttgatgaaaa aaactttttt cttactggtg ttaggcttgt tttgccttct tccactctct   60
gtttttgcca ttgatttcaa gataaactct tatcaagggg atttgtatat tcatgcagac   120
aatacggcag agtttagaca gaagatagtt taccagtttg aggaggactt taagggccaa   180
atcgtgggac ttggacgtgc tggtaagatg cctagcgggt ttgacattga ccctcatcca   240
aagattcagg ccgcgaaaaa cggtgcagaa ctagcagatg tgactagcga agtaacagaa   300
gaagcggatg gttatactgt gagagtctat aatccaggtc aggagggcga catagttgaa   360
gttgacctcg tctggaactt aaaaaattta cttttccttt atgatgatat cgctgaatta   420
aattggcaac ctctgacaga tagttcagag tctattgaaa agtttgaatt tcatgtaagg   480
ggagacaagg gggctgaaaa actctttttc catacaggga aactttttag agagggaacg   540
attgaaaaga gtaaccttga ttatactatc cgtttagaca atcttccggc taagcgtgga   600
gttgagttgc atgcctattg gcctcggacc gattttgcta gcgctaggga tcagggattg   660
aaagggaatc gtttagaaga gtttaataag atagaagact cgattgttag agaaaaagat   720
cagagtaaac aactcgttac ttgggtcctc ccttcgatcc tttccatctc cttgttattg   780
agtgtctgct tctattttat ttatagaaga aagaccactc cttcagtcaa atatgccaaa   840
aatcatcgtc tctatgaacc accaatggaa ttagagccta tggttttatc agaagcagtc   900
tactcgacct ccttggagga agtgagtccc ttggtcaagg gagctggaaa attcaccttt   960
gatcaactta ttcaagctac cttgctagat gtgatagacc gtgggaatgt ctctatcatt   1020
tcagaaggag atgcagttgg tttgaggcta gtaaaagaag atggtttgtc aagctttgag   1080
aaagactgcc taaatctagc tttttcaggt aaaaaagaag aaactctttc caatttgttt   1140
gcggattaca aggtatctga tagtctttat cgtagagcca aagtttctga tgaaaaacgg   1200
attcaagcaa gagggcttca actcaaatct tcttttgaag aggtattgaa ccagatgcaa   1260
gaaggagtga gaaaacgagt ttccttctgg gggctcccag attattatcg tcctttaact   1320
ggtggggaaa aggccttgca agtgggtatg ggtgccttga ctatcctgcc cctatttatc   1380
ggatttggtt tgttcttgta cagtttagac gttcatggct atctttacct ccctttgcca   1440
atacttggtt ttctagggtt agttttgtct gttttctatt attggaagct tcgactagat   1500
aatcgtgatg gtgttctaaa tgaagcggga gctgaggtct actatctctg gaccagtttt   1560
gaaaatatgt tgcgtgagat tgcacgattg gatcaggctg aactggaaag tattgtggtc   1620
tggaatcgcc tcttggtcta tgcgacctta tttggctatg cggacaaggt tagtcatttg   1680
atgaaggttc atcagattca agtggaaaat ccagatatca atctctatgt agcttatggc   1740
tggcacagta cgttttatca ttcaacagca caaatgagcc attatgctag tgtcgcaaat   1800
acagcaagca cctactctgt atcttctgga agtggaagtt ctggtggtgg cttctctgga   1860
ggcggaggtg gcggcagtat cggtgccttt                                    1890

<210>   758
<211>   630
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15902454 (0.E+01)

<400>   758
Met Met Lys Lys Thr Phe Phe Leu Leu Val Leu Gly Leu Phe Cys Leu 
1               5                   10                  15      

Leu Pro Leu Ser Val Phe Ala Ile Asp Phe Lys Ile Asn Ser Tyr Gln 
            20                  25                  30          

Gly Asp Leu Tyr Ile His Ala Asp Asn Thr Ala Glu Phe Arg Gln Lys 
        35                  40                  45              

Ile Val Tyr Gln Phe Glu Glu Asp Phe Lys Gly Gln Ile Val Gly Leu 
    50                  55                  60                  

Gly Arg Ala Gly Lys Met Pro Ser Gly Phe Asp Ile Asp Pro His Pro 
65                  70                  75                  80  

Lys Ile Gln Ala Ala Lys Asn Gly Ala Glu Leu Ala Asp Val Thr Ser 
                85                  90                  95      

Glu Val Thr Glu Glu Ala Asp Gly Tyr Thr Val Arg Val Tyr Asn Pro 
            100                 105                 110         

Gly Gln Glu Gly Asp Ile Val Glu Val Asp Leu Val Trp Asn Leu Lys 
        115                 120                 125             


Asn Leu Leu Phe Leu Tyr Asp Asp Ile Ala Glu Leu Asn Trp Gln Pro 
    130                 135                 140                 

Leu Thr Asp Ser Ser Glu Ser Ile Glu Lys Phe Glu Phe His Val Arg 
145                 150                 155                 160 

Gly Asp Lys Gly Ala Glu Lys Leu Phe Phe His Thr Gly Lys Leu Phe 
                165                 170                 175     

Arg Glu Gly Thr Ile Glu Lys Ser Asn Leu Asp Tyr Thr Ile Arg Leu 
            180                 185                 190         

Asp Asn Leu Pro Ala Lys Arg Gly Val Glu Leu His Ala Tyr Trp Pro 
        195                 200                 205             

Arg Thr Asp Phe Ala Ser Ala Arg Asp Gln Gly Leu Lys Gly Asn Arg 
    210                 215                 220                 

Leu Glu Glu Phe Asn Lys Ile Glu Asp Ser Ile Val Arg Glu Lys Asp 
225                 230                 235                 240 

Gln Ser Lys Gln Leu Val Thr Trp Val Leu Pro Ser Ile Leu Ser Ile 
                245                 250                 255     

Ser Leu Leu Leu Ser Val Cys Phe Tyr Phe Ile Tyr Arg Arg Lys Thr 
            260                 265                 270         

Thr Pro Ser Val Lys Tyr Ala Lys Asn His Arg Leu Tyr Glu Pro Pro 
        275                 280                 285             

Met Glu Leu Glu Pro Met Val Leu Ser Glu Ala Val Tyr Ser Thr Ser 
    290                 295                 300                 

Leu Glu Glu Val Ser Pro Leu Val Lys Gly Ala Gly Lys Phe Thr Phe 
305                 310                 315                 320 

Asp Gln Leu Ile Gln Ala Thr Leu Leu Asp Val Ile Asp Arg Gly Asn 
                325                 330                 335     

Val Ser Ile Ile Ser Glu Gly Asp Ala Val Gly Leu Arg Leu Val Lys 
            340                 345                 350         

Glu Asp Gly Leu Ser Ser Phe Glu Lys Asp Cys Leu Asn Leu Ala Phe 
        355                 360                 365             

Ser Gly Lys Lys Glu Glu Thr Leu Ser Asn Leu Phe Ala Asp Tyr Lys 
    370                 375                 380                 

Val Ser Asp Ser Leu Tyr Arg Arg Ala Lys Val Ser Asp Glu Lys Arg 
385                 390                 395                 400 

Ile Gln Ala Arg Gly Leu Gln Leu Lys Ser Ser Phe Glu Glu Val Leu 
                405                 410                 415     

Asn Gln Met Gln Glu Gly Val Arg Lys Arg Val Ser Phe Trp Gly Leu 
            420                 425                 430         

Pro Asp Tyr Tyr Arg Pro Leu Thr Gly Gly Glu Lys Ala Leu Gln Val 
        435                 440                 445             

Gly Met Gly Ala Leu Thr Ile Leu Pro Leu Phe Ile Gly Phe Gly Leu 
    450                 455                 460                 

Phe Leu Tyr Ser Leu Asp Val His Gly Tyr Leu Tyr Leu Pro Leu Pro 
465                 470                 475                 480 

Ile Leu Gly Phe Leu Gly Leu Val Leu Ser Val Phe Tyr Tyr Trp Lys 
                485                 490                 495     

Leu Arg Leu Asp Asn Arg Asp Gly Val Leu Asn Glu Ala Gly Ala Glu 
            500                 505                 510         

Val Tyr Tyr Leu Trp Thr Ser Phe Glu Asn Met Leu Arg Glu Ile Ala 
        515                 520                 525             

Arg Leu Asp Gln Ala Glu Leu Glu Ser Ile Val Val Trp Asn Arg Leu 
    530                 535                 540                 

Leu Val Tyr Ala Thr Leu Phe Gly Tyr Ala Asp Lys Val Ser His Leu 
545                 550                 555                 560 

Met Lys Val His Gln Ile Gln Val Glu Asn Pro Asp Ile Asn Leu Tyr 
                565                 570                 575     

Val Ala Tyr Gly Trp His Ser Thr Phe Tyr His Ser Thr Ala Gln Met 
            580                 585                 590         

Ser His Tyr Ala Ser Val Ala Asn Thr Ala Ser Thr Tyr Ser Val Ser 
        595                 600                 605             

Ser Gly Ser Gly Ser Ser Gly Gly Gly Phe Ser Gly Gly Gly Gly Gly 
    610                 615                 620                 

Gly Ser Ile Gly Ala Phe 
625                 630 

<210>   759
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   759
ttgaaaaaat ggactttttc aagggctttt tgccgtgctc taaaatcatc gccaaatcat   60
caaattgaaa taagaaatag tttagataaa actattgact tttcttatag tttgtctttt   120
ttctatcttc cattatatca tactttttca gtctatggta gctctctt                168

<210>   760
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Degenerate transposase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902455 (1.E-16)

<400>   760
Met Lys Lys Trp Thr Phe Ser Arg Ala Phe Cys Arg Ala Leu Lys Ser 
1               5                   10                  15      

Ser Pro Asn His Gln Ile Glu Ile Arg Asn Ser Leu Asp Lys Thr Ile 
            20                  25                  30          

Asp Phe Ser Tyr Ser Leu Ser Phe Phe Tyr Leu Pro Leu Tyr His Thr 
        35                  40                  45              

Phe Ser Val Tyr Gly Ser Ser Leu 
    50                  55      

<210>   761
<211>   273
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   761
ttgacacgct accctaatcc tcagaaaagg attgaggcag gatttgataa gctgatagaa   60
attaagcgat tgaccgcttc taaaattcag gatatcctct cagtcgcacc tcgttctatc   120
ggaacaacat ctcctgctcg tgaattcgaa atcatcaagc attacaagag gctcattgac   180
aaggcggaaa catgtatcaa tgactcgatg gctgagttca actcggtcat cacgacggtt   240
actgggattg gggatcgttt agggcggtca ttt                                273

<210>   762
<211>   91
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   762
Met Thr Arg Tyr Pro Asn Pro Gln Lys Arg Ile Glu Ala Gly Phe Asp 
1               5                   10                  15      

Lys Leu Ile Glu Ile Lys Arg Leu Thr Ala Ser Lys Ile Gln Asp Ile 
            20                  25                  30          

Leu Ser Val Ala Pro Arg Ser Ile Gly Thr Thr Ser Pro Ala Arg Glu 
        35                  40                  45              

Phe Glu Ile Ile Lys His Tyr Lys Arg Leu Ile Asp Lys Ala Glu Thr 
    50                  55                  60                  

Cys Ile Asn Asp Ser Met Ala Glu Phe Asn Ser Val Ile Thr Thr Val 
65                  70                  75                  80  

Thr Gly Ile Gly Asp Arg Leu Gly Arg Ser Phe 
                85                  90      

<210>   763
<211>   525
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   763
atgctttatg taggcattga tatcgctaaa aataaacacg atgttacagc cttgaatgtt   60
ccaggaaaaa ctgttcttaa accactcact ttttcaaata ataaagctgg ttttgaactc   120
ttagatctgt ctattcgaca gatcaaccaa gactgtctca tcgctcttga agatactgga   180
cattatgcct ttaatctact gaacttcctg catgaacaag gatataaagt ttacacctac   240
aatcctttgc tcatcaagga atttgccaaa tcattatcac ttcgcaagac taaaacggat   300
aagaaagacg ctcatggcat cgctcttaaa cttctttctg accccaatcg tgaacaattt   360
caacacgata atcggcaagt agacctaaaa atactggcta gacatattca tcgtctcaag   420
aaaaacagtc tgattggaaa gtacaataca ctcgttgtct tgatatcatc tttcctgagt   480
tggataaaat cgttggaaag cattcagaat atacctacca actct                   525

<210>   764
<211>   175
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, IS116/IS110/IS902 family, degenerate
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902863 (e-173)

<400>   764
Met Leu Tyr Val Gly Ile Asp Ile Ala Lys Asn Lys His Asp Val Thr 
1               5                   10                  15      

Ala Leu Asn Val Pro Gly Lys Thr Val Leu Lys Pro Leu Thr Phe Ser 
            20                  25                  30          

Asn Asn Lys Ala Gly Phe Glu Leu Leu Asp Leu Ser Ile Arg Gln Ile 
        35                  40                  45              

Asn Gln Asp Cys Leu Ile Ala Leu Glu Asp Thr Gly His Tyr Ala Phe 
    50                  55                  60                  

Asn Leu Leu Asn Phe Leu His Glu Gln Gly Tyr Lys Val Tyr Thr Tyr 
65                  70                  75                  80  

Asn Pro Leu Leu Ile Lys Glu Phe Ala Lys Ser Leu Ser Leu Arg Lys 
                85                  90                  95      

Thr Lys Thr Asp Lys Lys Asp Ala His Gly Ile Ala Leu Lys Leu Leu 
            100                 105                 110         

Ser Asp Pro Asn Arg Glu Gln Phe Gln His Asp Asn Arg Gln Val Asp 
        115                 120                 125             

Leu Lys Ile Leu Ala Arg His Ile His Arg Leu Lys Lys Asn Ser Leu 
    130                 135                 140                 

Ile Gly Lys Tyr Asn Thr Leu Val Val Leu Ile Ser Ser Phe Leu Ser 
145                 150                 155                 160 

Trp Ile Lys Ser Leu Glu Ser Ile Gln Asn Ile Pro Thr Asn Ser 
                165                 170                 175 

<210>   765
<211>   843
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   765
atgtatctta ttgaaatttt aaaatctatc ttcttcggaa ttgttgaagg aattacggaa   60
tggttgccga tttccagtac aggtcacttg attttagcag aggaattcat ccaataccaa   120
aatcaaaatg aagcctttat gtccatgttt aatgtcgtga ttcagcttgg tgctatttta   180
gcagttatgg tgatttattt taacaagctc aatcctttta aaccgaccaa ggacaaacag   240
gaagttcgta agacttggag actatggttg aaggtcttga ttgctacttt acctttactt   300
ggtgtcttta aatttgatga ttggtttgat acccacttcc ataacatggt ttcagttgct   360
ctcatgttga ttatctacgg ggttgccttc atctatttgg aaaagcgcaa taaagcgcgt   420
gctatcgagc caagtgtaac agagttggac aagcttcctt atacgaccgc tttctatatc   480
ggactcttcc aagttcttgc tcttttacca gggactagcc gttcaggtgc aacgattgtc   540
ggtggtttgt taaatggaac cagtcgttca gttgtgacag aatttacctt ctatcttggg   600
attcctgtta tgtttggagc tagtgcctta aagattttca aatttgtgaa agccggagaa   660
ctcttgagct ttgggcaatt gtttttgctc ttggtcgcga tgggagtagc ttttgcggtc   720
agcatggtgg ctattcgctt cttgaccagc tatgtgaaaa aacacgactt cacccttttt   780
ggtaaatacc gtatcgtgct tggtagtgtt ttgctacttt acagttttgt ccgtttattt   840
gta                                                                 843

<210>   766
<211>   281
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacitracin resistance protein (bacA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902457 (e-158)

<400>   766
Met Tyr Leu Ile Glu Ile Leu Lys Ser Ile Phe Phe Gly Ile Val Glu 
1               5                   10                  15      

Gly Ile Thr Glu Trp Leu Pro Ile Ser Ser Thr Gly His Leu Ile Leu 
            20                  25                  30          

Ala Glu Glu Phe Ile Gln Tyr Gln Asn Gln Asn Glu Ala Phe Met Ser 
        35                  40                  45              

Met Phe Asn Val Val Ile Gln Leu Gly Ala Ile Leu Ala Val Met Val 
    50                  55                  60                  

Ile Tyr Phe Asn Lys Leu Asn Pro Phe Lys Pro Thr Lys Asp Lys Gln 
65                  70                  75                  80  

Glu Val Arg Lys Thr Trp Arg Leu Trp Leu Lys Val Leu Ile Ala Thr 
                85                  90                  95      

Leu Pro Leu Leu Gly Val Phe Lys Phe Asp Asp Trp Phe Asp Thr His 
            100                 105                 110         

Phe His Asn Met Val Ser Val Ala Leu Met Leu Ile Ile Tyr Gly Val 
        115                 120                 125             

Ala Phe Ile Tyr Leu Glu Lys Arg Asn Lys Ala Arg Ala Ile Glu Pro 
    130                 135                 140                 

Ser Val Thr Glu Leu Asp Lys Leu Pro Tyr Thr Thr Ala Phe Tyr Ile 
145                 150                 155                 160 

Gly Leu Phe Gln Val Leu Ala Leu Leu Pro Gly Thr Ser Arg Ser Gly 
                165                 170                 175     

Ala Thr Ile Val Gly Gly Leu Leu Asn Gly Thr Ser Arg Ser Val Val 
            180                 185                 190         

Thr Glu Phe Thr Phe Tyr Leu Gly Ile Pro Val Met Phe Gly Ala Ser 
        195                 200                 205             

Ala Leu Lys Ile Phe Lys Phe Val Lys Ala Gly Glu Leu Leu Ser Phe 
    210                 215                 220                 

Gly Gln Leu Phe Leu Leu Leu Val Ala Met Gly Val Ala Phe Ala Val 
225                 230                 235                 240 

Ser Met Val Ala Ile Arg Phe Leu Thr Ser Tyr Val Lys Lys His Asp 
                245                 250                 255     

Phe Thr Leu Phe Gly Lys Tyr Arg Ile Val Leu Gly Ser Val Leu Leu 
            260                 265                 270         

Leu Tyr Ser Phe Val Arg Leu Phe Val 
        275                 280     

<210>   767
<211>   1125
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   767
ttgaggttgc agatagagct gacgtggttt gaagagattt tcgaagagta taaaaaggtg   60
ctaggcatgt tgatttttcc tttgttaaat gatttgtcaa gaaaaatcat ccatattgac   120
atggatgcct tttttgctgc agtggaaatc agggataatc ctaaactcag aggaaaacct   180
gtcattattg gaagcgaccc tcggcaaaca ggtggacggg gagtcgtttc tacctgtagt   240
tatgaggcaa gagcttttgg tgtccattct gccatgagtt ccaaggaagc ttatgaacgt   300
tgtccccagg ctgtctttat ctcagggaat tatgagaaat acaagtctgt gggactccag   360
attcgagcta tttttaagcg ctatacagat ttgattgaac ccatgagcat tgacgaagcc   420
tatttggatg tgacagaaaa taaactcggt atcaagtcag cggtcaaaat tgctcgcctc   480
attcaaaaag atatctggca agaactccat ctaactgctt ccgcaggcgt ttcttacaac   540
aaattcttag ctaaaatggc gagtgattat caaaaaccac atggtttgac agtgattcta   600
cctgaacagg ctgaggattt tctcaaacaa atggatattt ccaaatttca tggagtagga   660
aaaaagacag tagaacgtct tcatcaaatg ggcgttttta ctggtgctga tttacttgaa   720
gttcctgagg taaccctaat agaccgtttt ggtagactag gctatgatct gtatcgaaag   780
gctcgtggca ttcacaactc tccagtcaaa tccaatcgca tccgtaaatc aatcggcaag   840
gagaaaacct acgggaagat tctccttgct gaggaagata tcaaaaaaga gctgactctt   900
ctatcagaaa aagtcgctct caatctacat caacaagaaa aagctggaaa aattgtcatt   960
ttgaaaatcc gctacgagga cttttcaact cttaccaaac gaaaaagtct tgctcaaaaa   1020
acacaagatg ctagtcagat aagccaaata gccctgcaac tctatgaaga attaagcaag   1080
aaagaaagag gtgtccgcct attggggatt accatgactg gattt                   1125

<210>   768
<211>   375
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-damage inducible protein P (dinP)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902458 (0.E+01)

<400>   768
Met Arg Leu Gln Ile Glu Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu 
1               5                   10                  15      

Tyr Lys Lys Val Leu Gly Met Leu Ile Phe Pro Leu Leu Asn Asp Leu 
            20                  25                  30          

Ser Arg Lys Ile Ile His Ile Asp Met Asp Ala Phe Phe Ala Ala Val 
        35                  40                  45              

Glu Ile Arg Asp Asn Pro Lys Leu Arg Gly Lys Pro Val Ile Ile Gly 
    50                  55                  60                  

Ser Asp Pro Arg Gln Thr Gly Gly Arg Gly Val Val Ser Thr Cys Ser 
65                  70                  75                  80  

Tyr Glu Ala Arg Ala Phe Gly Val His Ser Ala Met Ser Ser Lys Glu 
                85                  90                  95      

Ala Tyr Glu Arg Cys Pro Gln Ala Val Phe Ile Ser Gly Asn Tyr Glu 
            100                 105                 110         

Lys Tyr Lys Ser Val Gly Leu Gln Ile Arg Ala Ile Phe Lys Arg Tyr 
        115                 120                 125             

Thr Asp Leu Ile Glu Pro Met Ser Ile Asp Glu Ala Tyr Leu Asp Val 
    130                 135                 140                 

Thr Glu Asn Lys Leu Gly Ile Lys Ser Ala Val Lys Ile Ala Arg Leu 
145                 150                 155                 160 

Ile Gln Lys Asp Ile Trp Gln Glu Leu His Leu Thr Ala Ser Ala Gly 
                165                 170                 175     

Val Ser Tyr Asn Lys Phe Leu Ala Lys Met Ala Ser Asp Tyr Gln Lys 
            180                 185                 190         

Pro His Gly Leu Thr Val Ile Leu Pro Glu Gln Ala Glu Asp Phe Leu 
        195                 200                 205             

Lys Gln Met Asp Ile Ser Lys Phe His Gly Val Gly Lys Lys Thr Val 
    210                 215                 220                 

Glu Arg Leu His Gln Met Gly Val Phe Thr Gly Ala Asp Leu Leu Glu 
225                 230                 235                 240 

Val Pro Glu Val Thr Leu Ile Asp Arg Phe Gly Arg Leu Gly Tyr Asp 
                245                 250                 255     

Leu Tyr Arg Lys Ala Arg Gly Ile His Asn Ser Pro Val Lys Ser Asn 
            260                 265                 270         

Arg Ile Arg Lys Ser Ile Gly Lys Glu Lys Thr Tyr Gly Lys Ile Leu 
        275                 280                 285             

Leu Ala Glu Glu Asp Ile Lys Lys Glu Leu Thr Leu Leu Ser Glu Lys 
    290                 295                 300                 

Val Ala Leu Asn Leu His Gln Gln Glu Lys Ala Gly Lys Ile Val Ile 
305                 310                 315                 320 

Leu Lys Ile Arg Tyr Glu Asp Phe Ser Thr Leu Thr Lys Arg Lys Ser 
                325                 330                 335     

Leu Ala Gln Lys Thr Gln Asp Ala Ser Gln Ile Ser Gln Ile Ala Leu 
            340                 345                 350         

Gln Leu Tyr Glu Glu Leu Ser Lys Lys Glu Arg Gly Val Arg Leu Leu 
        355                 360                 365             

Gly Ile Thr Met Thr Gly Phe 
    370                 375 

<210>   769
<211>   2322
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   769
atggttgtta agacagttgt tgaagcacaa gatatttttg acaaagcttg ggaaggcttc   60
aaaggcgtag attggaaaga aaaagcaagt gtatcacgat ttgtacaagc taactacaca   120
ccttatgatg gagacgaaag cttccttgca ggaccaacag agcgttcact tcacatcaag   180
aaaattgtag aagaaactaa agcacactac gaagaaactc gtttcccaat ggacactcgt   240
ccaacatcta tcgctgatat ccctgctgga tttatcgaca aagaaaatga agttatcttc   300
ggtatccaaa acgatgaact cttcaaattg aacttcatgc caaaaggtgg tatccgtatg   360
gctgaaacta ctttgaaaga aaatggatac gaaccagacc cagctgttca cgaaatcttc   420
actaaatatg taacaacagt taacgacggt attttccgtg cctacacttc aaatattcgt   480
cgcgctcgtc acgcacacac tgtaactggt cttccagatg catactcacg cggacgtatc   540
atcggtgttt acgcacgtct tgctctttac ggtgcagact acttgatgca agaaaaagta   600
aatgactgga atgcaatcaa agaaatcgat gaagaaacaa tccgtcttcg tgaagaagta   660
aaccttcaat accaagcatt gcaacaagtt gttcgcctgg gtgaccttta cggggttgat   720
gttcgcaaac cagcgatgaa cgtgaaagaa gcaatccaat gggttaacat tgctttcatg   780
gctgtctgcc gtgtgattaa cggtgctgct acatctctag gtcgtgtacc aatcgtattg   840
gacatctttg cagaacgtga ccttgctcgt ggtacattta ctgaatcaga aatccaagaa   900
ttcgttgatg atttcgttat gaaacttcgt acagttaaat ttgctcgtac aaaagcttat   960
gaccaattgt actcaggtga cccaaccttt atcacaactt ctatggctgg tatgggtaac   1020
gacggtcgtc accgtgttac taagatggac taccgtttct tgaacactct tgacaacatc   1080
ggtaactcac cagaaccaaa cttgacagtt ctttggactg acaaattgcc atacaacttc   1140
cgtcgctact gtatgcacat gagccacaaa cactcttcta tccaatacga aggtgtaaca   1200
acaatggcta aagacggata tggtgaaatg agctgtatct catgctgtgt gtctccactt   1260
gatccagaaa atgaagaaca acgccacaac atccagtact tcggtgctcg tgtaaacgtt   1320
cttaaagccc ttcttactgg tttgaatggt ggttacgacg atgttcacaa agactacaaa   1380
gtatttgata tcgaaccaat ccgtgacgaa gttcttgaat ttgaatcagt taaagcgaac   1440
tttgaaaaat ctcttgactg gttgactgac acttacgtag atgccttgaa catcatccac   1500
tacatgactg ataggtacaa ctacgaagct gttcaaatgg ccttcttgcc aactaaacaa   1560
cgtgccaaca tgggattcgg tatctgtgga tttgctaaca ctgttgatac attgtcagct   1620
atcaaatacg ctacagttaa accaatccgt gacgaagatg gctacatcta cgattacgaa   1680
acaatcggtg actacccacg ctggggtgaa gatgacccac gttcaaacga attggcagaa   1740
tggttgatcg aagcttacac aactcgtcta cgtagccaca aactatacaa agacgcagaa   1800
gctacagtat cacttttgac aatcacatct aacgttgctt actctaaaca aactggtaac   1860
tcaccagttc acaaaggtgt atacctcaac gaagatggtt ctgtgaactt gtctaaactt   1920
gaattcttct caccaggtgc taacccatct aacaaagcta aaggtggttg gttgcaaaac   1980
ttgaactcac tttctagcct tgactttagt tatgcagctg acggtatctc attgactaca   2040
caagtatcac ctcgcgctct tggtaagact cgtgatgaac aagttgataa cttggtaaca   2100
attcttgatg gttacttcga aaacggtgga caacacgtta acttgaacgt tatggacttg   2160
aacgatgttt acgaaaaaat catgtcaggc gaagacgtta tcgtacgtat ctctggatac   2220
tgtgtaaaca ctaaatacct cactccagaa caaaaaactg aattgacaca acgtgtcttc   2280
cacgaagttc tttcaatgga tgacgccttg gatgcattga gc                      2322

<210>   770
<211>   774
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   formate acetyltransferase (pfl)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902459 (0.E+01)

<400>   770
Met Val Val Lys Thr Val Val Glu Ala Gln Asp Ile Phe Asp Lys Ala 
1               5                   10                  15      

Trp Glu Gly Phe Lys Gly Val Asp Trp Lys Glu Lys Ala Ser Val Ser 
            20                  25                  30          

Arg Phe Val Gln Ala Asn Tyr Thr Pro Tyr Asp Gly Asp Glu Ser Phe 
        35                  40                  45              

Leu Ala Gly Pro Thr Glu Arg Ser Leu His Ile Lys Lys Ile Val Glu 
    50                  55                  60                  

Glu Thr Lys Ala His Tyr Glu Glu Thr Arg Phe Pro Met Asp Thr Arg 
65                  70                  75                  80  

Pro Thr Ser Ile Ala Asp Ile Pro Ala Gly Phe Ile Asp Lys Glu Asn 
                85                  90                  95      

Glu Val Ile Phe Gly Ile Gln Asn Asp Glu Leu Phe Lys Leu Asn Phe 
            100                 105                 110         

Met Pro Lys Gly Gly Ile Arg Met Ala Glu Thr Thr Leu Lys Glu Asn 
        115                 120                 125             

Gly Tyr Glu Pro Asp Pro Ala Val His Glu Ile Phe Thr Lys Tyr Val 
    130                 135                 140                 

Thr Thr Val Asn Asp Gly Ile Phe Arg Ala Tyr Thr Ser Asn Ile Arg 
145                 150                 155                 160 

Arg Ala Arg His Ala His Thr Val Thr Gly Leu Pro Asp Ala Tyr Ser 
                165                 170                 175     

Arg Gly Arg Ile Ile Gly Val Tyr Ala Arg Leu Ala Leu Tyr Gly Ala 
            180                 185                 190         

Asp Tyr Leu Met Gln Glu Lys Val Asn Asp Trp Asn Ala Ile Lys Glu 
        195                 200                 205             

Ile Asp Glu Glu Thr Ile Arg Leu Arg Glu Glu Val Asn Leu Gln Tyr 
    210                 215                 220                 

Gln Ala Leu Gln Gln Val Val Arg Leu Gly Asp Leu Tyr Gly Val Asp 
225                 230                 235                 240 

Val Arg Lys Pro Ala Met Asn Val Lys Glu Ala Ile Gln Trp Val Asn 
                245                 250                 255     

Ile Ala Phe Met Ala Val Cys Arg Val Ile Asn Gly Ala Ala Thr Ser 
            260                 265                 270         

Leu Gly Arg Val Pro Ile Val Leu Asp Ile Phe Ala Glu Arg Asp Leu 
        275                 280                 285             

Ala Arg Gly Thr Phe Thr Glu Ser Glu Ile Gln Glu Phe Val Asp Asp 
    290                 295                 300                 

Phe Val Met Lys Leu Arg Thr Val Lys Phe Ala Arg Thr Lys Ala Tyr 
305                 310                 315                 320 

Asp Gln Leu Tyr Ser Gly Asp Pro Thr Phe Ile Thr Thr Ser Met Ala 
                325                 330                 335     

Gly Met Gly Asn Asp Gly Arg His Arg Val Thr Lys Met Asp Tyr Arg 
            340                 345                 350         

Phe Leu Asn Thr Leu Asp Asn Ile Gly Asn Ser Pro Glu Pro Asn Leu 
        355                 360                 365             

Thr Val Leu Trp Thr Asp Lys Leu Pro Tyr Asn Phe Arg Arg Tyr Cys 
    370                 375                 380                 

Met His Met Ser His Lys His Ser Ser Ile Gln Tyr Glu Gly Val Thr 
385                 390                 395                 400 

Thr Met Ala Lys Asp Gly Tyr Gly Glu Met Ser Cys Ile Ser Cys Cys 
                405                 410                 415     

Val Ser Pro Leu Asp Pro Glu Asn Glu Glu Gln Arg His Asn Ile Gln 
            420                 425                 430         

Tyr Phe Gly Ala Arg Val Asn Val Leu Lys Ala Leu Leu Thr Gly Leu 
        435                 440                 445             

Asn Gly Gly Tyr Asp Asp Val His Lys Asp Tyr Lys Val Phe Asp Ile 
    450                 455                 460                 

Glu Pro Ile Arg Asp Glu Val Leu Glu Phe Glu Ser Val Lys Ala Asn 
465                 470                 475                 480 

Phe Glu Lys Ser Leu Asp Trp Leu Thr Asp Thr Tyr Val Asp Ala Leu 
                485                 490                 495     

Asn Ile Ile His Tyr Met Thr Asp Arg Tyr Asn Tyr Glu Ala Val Gln 
            500                 505                 510         

Met Ala Phe Leu Pro Thr Lys Gln Arg Ala Asn Met Gly Phe Gly Ile 
        515                 520                 525             

Cys Gly Phe Ala Asn Thr Val Asp Thr Leu Ser Ala Ile Lys Tyr Ala 
    530                 535                 540                 

Thr Val Lys Pro Ile Arg Asp Glu Asp Gly Tyr Ile Tyr Asp Tyr Glu 
545                 550                 555                 560 

Thr Ile Gly Asp Tyr Pro Arg Trp Gly Glu Asp Asp Pro Arg Ser Asn 
                565                 570                 575     

Glu Leu Ala Glu Trp Leu Ile Glu Ala Tyr Thr Thr Arg Leu Arg Ser 
            580                 585                 590         

His Lys Leu Tyr Lys Asp Ala Glu Ala Thr Val Ser Leu Leu Thr Ile 
        595                 600                 605             

Thr Ser Asn Val Ala Tyr Ser Lys Gln Thr Gly Asn Ser Pro Val His 
    610                 615                 620                 

Lys Gly Val Tyr Leu Asn Glu Asp Gly Ser Val Asn Leu Ser Lys Leu 
625                 630                 635                 640 

Glu Phe Phe Ser Pro Gly Ala Asn Pro Ser Asn Lys Ala Lys Gly Gly 
                645                 650                 655     

Trp Leu Gln Asn Leu Asn Ser Leu Ser Ser Leu Asp Phe Ser Tyr Ala 
            660                 665                 670         

Ala Asp Gly Ile Ser Leu Thr Thr Gln Val Ser Pro Arg Ala Leu Gly 
        675                 680                 685             

Lys Thr Arg Asp Glu Gln Val Asp Asn Leu Val Thr Ile Leu Asp Gly 
    690                 695                 700                 

Tyr Phe Glu Asn Gly Gly Gln His Val Asn Leu Asn Val Met Asp Leu 
705                 710                 715                 720 

Asn Asp Val Tyr Glu Lys Ile Met Ser Gly Glu Asp Val Ile Val Arg 
                725                 730                 735     

Ile Ser Gly Tyr Cys Val Asn Thr Lys Tyr Leu Thr Pro Glu Gln Lys 
            740                 745                 750         

Thr Glu Leu Thr Gln Arg Val Phe His Glu Val Leu Ser Met Asp Asp 
        755                 760                 765             

Ala Leu Asp Ala Leu Ser 
    770                 

<210>   771
<211>   1266
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   771
atggaacaca tcaatcatac cacattactc atcggaataa aagacaaaaa catcacctta   60
aataaagcca ttcagcacga tacccatatc gaagtcttcg ctacacttga ttatcaccca   120
cctaaatgta aacactgtaa aggaaaacaa atcaaatacg acttccaaaa gccttctaaa   180
atccctttta tcgagattgg tggtttccct agcctcattc atttgaaaaa gagacgattt   240
caatgcaagt cctgtcggaa agtcactgta gctgaaacaa ctctcgttca gaaaaattgc   300
caaatctcgg aaatggtgag acagaaaatt gcccaactcc tactcaacag agaggctctt   360
acacatatcg cttctaaatt agccatctct acctctacct ctacctctac cgtctatcgt   420
aagctcaagc aatttcattt ccaagaggat tacaccactt tgcctgaaat cctctcctgg   480
gatgaattct cctaccagaa ggggaaattg gctttcattg ctcaggattt caacactaag   540
aaaatcatga ccattcttga taacagacgt caaacaacca tccgaaatca tttcttcaag   600
tactcgaaag aagctagaaa aaaagttaaa gtcgtcactg ttgatatgtc tggaagttat   660
atccctctca ttaagaaatt atttcccaat gctaaaattg ttctcgatcg tttccacatt   720
gtccaacaca tgagcagggc tcttaatcag actagaatca acatcatgaa gcaatttgat   780
gataaatctc tggaatacag agctcttaaa tattactgga aatttatcct aaaagatagt   840
cggaaactct ctcttaagcc tttctatgct agaactttca gagagacctt aactcctagg   900
gagtgtctga agaaaatctt tactctagta cctgaactta aagattacta tgacctgtat   960
caactactcc tatttcatct acaagagaag aatactgacc agttttgggg cttaattcaa   1020
gacacgttac ctcatctcaa ccgcaccttt aaaaccactt tgagcacatt tatttgctat   1080
aaaaactaca tcactaacgc cattgaattg ccttattcta acgctaaact tgaggccact   1140
aacaaactca tcaaagacat caagcgcaat gcctttggtt ttcggaactt tgaaaacttc   1200
aaaaaacgga tttttatcgc cctgaacatc aaaaaagaaa ggacgaaatt tgtcctttct   1260
caagct                                                              1266

<210>   772
<211>   422
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903763 (e-129)

<400>   772
Met Glu His Ile Asn His Thr Thr Leu Leu Ile Gly Ile Lys Asp Lys 
1               5                   10                  15      

Asn Ile Thr Leu Asn Lys Ala Ile Gln His Asp Thr His Ile Glu Val 
            20                  25                  30          

Phe Ala Thr Leu Asp Tyr His Pro Pro Lys Cys Lys His Cys Lys Gly 
        35                  40                  45              

Lys Gln Ile Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Phe Ile 
    50                  55                  60                  

Glu Ile Gly Gly Phe Pro Ser Leu Ile His Leu Lys Lys Arg Arg Phe 
65                  70                  75                  80  

Gln Cys Lys Ser Cys Arg Lys Val Thr Val Ala Glu Thr Thr Leu Val 
                85                  90                  95      

Gln Lys Asn Cys Gln Ile Ser Glu Met Val Arg Gln Lys Ile Ala Gln 
            100                 105                 110         

Leu Leu Leu Asn Arg Glu Ala Leu Thr His Ile Ala Ser Lys Leu Ala 
        115                 120                 125             

Ile Ser Thr Ser Thr Ser Thr Ser Thr Val Tyr Arg Lys Leu Lys Gln 
    130                 135                 140                 

Phe His Phe Gln Glu Asp Tyr Thr Thr Leu Pro Glu Ile Leu Ser Trp 
145                 150                 155                 160 

Asp Glu Phe Ser Tyr Gln Lys Gly Lys Leu Ala Phe Ile Ala Gln Asp 
                165                 170                 175     

Phe Asn Thr Lys Lys Ile Met Thr Ile Leu Asp Asn Arg Arg Gln Thr 
            180                 185                 190         

Thr Ile Arg Asn His Phe Phe Lys Tyr Ser Lys Glu Ala Arg Lys Lys 
        195                 200                 205             

Val Lys Val Val Thr Val Asp Met Ser Gly Ser Tyr Ile Pro Leu Ile 
    210                 215                 220                 

Lys Lys Leu Phe Pro Asn Ala Lys Ile Val Leu Asp Arg Phe His Ile 
225                 230                 235                 240 

Val Gln His Met Ser Arg Ala Leu Asn Gln Thr Arg Ile Asn Ile Met 
                245                 250                 255     

Lys Gln Phe Asp Asp Lys Ser Leu Glu Tyr Arg Ala Leu Lys Tyr Tyr 
            260                 265                 270         

Trp Lys Phe Ile Leu Lys Asp Ser Arg Lys Leu Ser Leu Lys Pro Phe 
        275                 280                 285             

Tyr Ala Arg Thr Phe Arg Glu Thr Leu Thr Pro Arg Glu Cys Leu Lys 
    290                 295                 300                 

Lys Ile Phe Thr Leu Val Pro Glu Leu Lys Asp Tyr Tyr Asp Leu Tyr 
305                 310                 315                 320 

Gln Leu Leu Leu Phe His Leu Gln Glu Lys Asn Thr Asp Gln Phe Trp 
                325                 330                 335     

Gly Leu Ile Gln Asp Thr Leu Pro His Leu Asn Arg Thr Phe Lys Thr 
            340                 345                 350         

Thr Leu Ser Thr Phe Ile Cys Tyr Lys Asn Tyr Ile Thr Asn Ala Ile 
        355                 360                 365             

Glu Leu Pro Tyr Ser Asn Ala Lys Leu Glu Ala Thr Asn Lys Leu Ile 
    370                 375                 380                 

Lys Asp Ile Lys Arg Asn Ala Phe Gly Phe Arg Asn Phe Glu Asn Phe 
385                 390                 395                 400 

Lys Lys Arg Ile Phe Ile Ala Leu Asn Ile Lys Lys Glu Arg Thr Lys 
                405                 410                 415     

Phe Val Leu Ser Gln Ala 
            420         

<210>   773
<211>   1527
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   773
atgctaaaca aatacattga aaaaagaatt acagataaaa ttaccatttt aaatatatta   60
ttggatattc ggtctattga actagatgaa ctgtctactt taacttcatt acaatctaaa   120
agtctcctaa gcattttgca ggaattacaa gaaacattcg aggaagagtt gacatttaat   180
ttagatacgc aacaagttca attaatcgaa caccattctc atcaaacgaa ttattacttc   240
catcagcttt ataaccaatc aactatttta aaaatactcc gcttctttct actacaaggt   300
aatcaaagct ttaacgaatt tacacaaaaa gagtatattt ccatcgcaac aggctaccgc   360
gtacgacaaa agtgtggctt gttactacgt tcagtaggtt tggaccttgt gaaaaatcaa   420
gtagttggtc ctgaatatcg cattcgtttt ttaattgcac tcctccagtt tcattttggt   480
attgagattt atgatttgaa tgatggaagt atggattggg tcacacatat gattgtgcag   540
tctaattctc aactcagtca tgaactgtta gaaatcacac ctgacgagta tgttcatttt   600
agcatactag tggcactcac ttggaaacgt cgggaatttc cacttgagtt ccctgagtcc   660
aaagagtttg aaaaattaaa aaacctcttt atgtatccga ttttgatgga acattgccaa   720
acttacttag agccacatgc caacatgact tttactcagg aagaactgga ttatatcttt   780
ttggtttatt gttctgctaa ttcttcgttt tccaaggaca aatggaatca agaaaaaaag   840
actcatacta ttcaactgat tcttcagcat acaagaggaa agcatctact atccaagttc   900
aagaatatct taggaaatga catttcgaat tctctttctt ttttaacagc actgactttc   960
ttaacaagaa cgtttttgtt tggtttacaa aatctagttc cctattataa ttattacgaa   1020
cattatggga ttgaaagcga caagccactg tatcatattt cgaaagcaat tgttcaagag   1080
tggatgactg agcagaagat tgaaggagtt atcgaccagc atcggctgta ccttttctca   1140
ctctacttga cagaaaccat cttttcctca ctacctgcta tcccgatttt tatcatttta   1200
aataatcaag cagatgtaaa cttaataaag tccattattt tacggaattt tactgacaaa   1260
gttgcctctg ttacaggata caatattcta attagtcctc ctccttcaga ggagcatttg   1320
acagagccat tgattattat tacaacgaaa gaatacctgc cttacgttaa aaagcagtat   1380
cccaaaggga aacatcactt tttgacgatt gccttagatt tgcatgttag ccaacagcgt   1440
ctcatctatc agacaattgt agatatccga aaagaggctt ttgacaaacg ggtcgcaatg   1500
attgctaaaa aggctcacta tttgtta                                       1527

<210>   774
<211>   509
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903664 (5.E-05)

<400>   774
Met Leu Asn Lys Tyr Ile Glu Lys Arg Ile Thr Asp Lys Ile Thr Ile 
1               5                   10                  15      

Leu Asn Ile Leu Leu Asp Ile Arg Ser Ile Glu Leu Asp Glu Leu Ser 
            20                  25                  30          

Thr Leu Thr Ser Leu Gln Ser Lys Ser Leu Leu Ser Ile Leu Gln Glu 
        35                  40                  45              

Leu Gln Glu Thr Phe Glu Glu Glu Leu Thr Phe Asn Leu Asp Thr Gln 
    50                  55                  60                  

Gln Val Gln Leu Ile Glu His His Ser His Gln Thr Asn Tyr Tyr Phe 
65                  70                  75                  80  

His Gln Leu Tyr Asn Gln Ser Thr Ile Leu Lys Ile Leu Arg Phe Phe 
                85                  90                  95      

Leu Leu Gln Gly Asn Gln Ser Phe Asn Glu Phe Thr Gln Lys Glu Tyr 
            100                 105                 110         

Ile Ser Ile Ala Thr Gly Tyr Arg Val Arg Gln Lys Cys Gly Leu Leu 
        115                 120                 125             

Leu Arg Ser Val Gly Leu Asp Leu Val Lys Asn Gln Val Val Gly Pro 
    130                 135                 140                 

Glu Tyr Arg Ile Arg Phe Leu Ile Ala Leu Leu Gln Phe His Phe Gly 
145                 150                 155                 160 

Ile Glu Ile Tyr Asp Leu Asn Asp Gly Ser Met Asp Trp Val Thr His 
                165                 170                 175     

Met Ile Val Gln Ser Asn Ser Gln Leu Ser His Glu Leu Leu Glu Ile 
            180                 185                 190         

Thr Pro Asp Glu Tyr Val His Phe Ser Ile Leu Val Ala Leu Thr Trp 
        195                 200                 205             

Lys Arg Arg Glu Phe Pro Leu Glu Phe Pro Glu Ser Lys Glu Phe Glu 
    210                 215                 220                 

Lys Leu Lys Asn Leu Phe Met Tyr Pro Ile Leu Met Glu His Cys Gln 
225                 230                 235                 240 

Thr Tyr Leu Glu Pro His Ala Asn Met Thr Phe Thr Gln Glu Glu Leu 
                245                 250                 255     

Asp Tyr Ile Phe Leu Val Tyr Cys Ser Ala Asn Ser Ser Phe Ser Lys 
            260                 265                 270         

Asp Lys Trp Asn Gln Glu Lys Lys Thr His Thr Ile Gln Leu Ile Leu 
        275                 280                 285             

Gln His Thr Arg Gly Lys His Leu Leu Ser Lys Phe Lys Asn Ile Leu 
    290                 295                 300                 

Gly Asn Asp Ile Ser Asn Ser Leu Ser Phe Leu Thr Ala Leu Thr Phe 
305                 310                 315                 320 

Leu Thr Arg Thr Phe Leu Phe Gly Leu Gln Asn Leu Val Pro Tyr Tyr 
                325                 330                 335     

Asn Tyr Tyr Glu His Tyr Gly Ile Glu Ser Asp Lys Pro Leu Tyr His 
            340                 345                 350         

Ile Ser Lys Ala Ile Val Gln Glu Trp Met Thr Glu Gln Lys Ile Glu 
        355                 360                 365             

Gly Val Ile Asp Gln His Arg Leu Tyr Leu Phe Ser Leu Tyr Leu Thr 
    370                 375                 380                 

Glu Thr Ile Phe Ser Ser Leu Pro Ala Ile Pro Ile Phe Ile Ile Leu 
385                 390                 395                 400 

Asn Asn Gln Ala Asp Val Asn Leu Ile Lys Ser Ile Ile Leu Arg Asn 
                405                 410                 415     

Phe Thr Asp Lys Val Ala Ser Val Thr Gly Tyr Asn Ile Leu Ile Ser 
            420                 425                 430         

Pro Pro Pro Ser Glu Glu His Leu Thr Glu Pro Leu Ile Ile Ile Thr 
        435                 440                 445             

Thr Lys Glu Tyr Leu Pro Tyr Val Lys Lys Gln Tyr Pro Lys Gly Lys 
    450                 455                 460                 

His His Phe Leu Thr Ile Ala Leu Asp Leu His Val Ser Gln Gln Arg 
465                 470                 475                 480 

Leu Ile Tyr Gln Thr Ile Val Asp Ile Arg Lys Glu Ala Phe Asp Lys 
                485                 490                 495     

Arg Val Ala Met Ile Ala Lys Lys Ala His Tyr Leu Leu 
            500                 505                 

<210>   775
<211>   2679
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   775
atgcttaaca gggagacaca catgaaaaaa gtaagaaaga tatttcagaa ggcagttgca   60
ggactgtgct gtatatctca gttgacagct ttttcttcga tagttgcttt agcagaaacg   120
cctgaaacca gtccagcgat aggaaaagta gtgattaagg agacaggcga aggaggagcg   180
cttctaggag atgccgtctt tgagttgaaa aacaatacgg atggcacaac tgtttcgcaa   240
aggacagagg cgcaaacagg agaagcgata ttttcaaaca taaaacctgg gacatacacc   300
ttgacagaag cccaacctcc agttggttat aaaccctcta ctaaacaatg gactgttgaa   360
gttgagaaga atggtcggac gactgtccaa ggtgaacagg tagaaaatcg agaagaggct   420
ctatctgacc agtatccaca aacagggact tatccagatg ttcaaacacc ttatcagatt   480
attaaggtag atggttcgga aaaaaacgga cagcacaagg cgttgaatcc gaatccatat   540
gaacgtgtga ttccagaagg tacactttca aagagaattt atcaagtgaa taatttggat   600
gataaccaat atggaatcga attgacggtt agtgggaaaa cagtgtatga acaaaaagat   660
aagtctgtgc cgctggatgt cgttatcttg ctcgataact caaatagtat gagtaacatt   720
cgaaacaaga atgctcgacg tgcggaaaga gctggtgagg cgacacgttc tcttattgat   780
aaaattacat ctgattcaga aaatagggta gcgcttgtga cttatgcttc cactatcttt   840
gatgggaccg agtttacagt agaaaaaggg gtagcagata aaaacggaaa gcgattgaat   900
gattctcttt tttggaatta tgatcagacg agttttacaa ccaataccaa agattatagt   960
tatttaaagc tgactaatga taagaatgac attgtagaat taaaaaataa ggtacctacc   1020
gaggcagaag accatgatgg aaatagattg atgtaccaat tcggtgccac ttttactcag   1080
aaagctttga tgaaggcaga tgagattttg acacaacaag cgagacaaaa tagtcaaaaa   1140
gtcattttcc atattacgga tggtgtccca actatgtcgt atccgattaa ttttaatcat   1200
gctacgtttg ctccatcata tcaaaatcaa ctaaatgcat tttttagtaa atctcctaat   1260
aaagatggaa tactattaag tgattttatt acgcaagcaa ctagtggaga acatacaatt   1320
gtacgcggag atgggcaaag ttaccagatg tttacagata agacagttta tgaaaaaggt   1380
gctcctgcag ctttcccagt taaacctgaa aaatattctg aaatgaaggc ggctggttat   1440
gcagttatag gcgatccaat taatggtgga tatatttggc ttaattggag agagagtatt   1500
ctggcttatc cgtttaattc taatactgct aaaattacca atcatggtga ccctacaaga   1560
tggtactata acgggaatat tgctcctgat gggtatgatg tctttacggt aggtattggt   1620
attaacggag atcctggtac ggatgaagca acggctacta gttttatgca aagtatttct   1680
agtaaacctg aaaactatac caatgttact gacacgacaa aaatattgga acagttgaat   1740
cgttatttcc acaccatcgt aactgaaaag aaatcaattg agaatggtac gattacagat   1800
ccgatgggtg agttaattga tttgcaattg ggcacagatg gaagatttga tccagcagat   1860
tacactttaa ctgcaaacga tggtagtcgc ttggagaatg gacaagctgt aggtggtcca   1920
caaaatgatg gtggtttgtt aaaaaatgca aaagtgctct atgatacgac tgagaaaagg   1980
attcgtgtaa caggtctgta ccttggaacg gatgaaaaag ttacgttgac ctacaatgtt   2040
cgtttgaatg atgagtttgt aagcaataaa ttttatgata ccaatggtcg aacaacctta   2100
catcctaagg aagtagaaca gaacacagtg cgcgacttcc cgattcctaa gattcgtgat   2160
gtgcggaagt atccagaaat cacaatttca aaagagaaaa aacttggtga cattgagttt   2220
attaaggtca ataaaaatga taaaaaacca ctgagaggtg cggtctttag tcttcaaaaa   2280
caacatccgg attatccaga tatttatgga gctattgatc aaaatggcac ttatcaaaat   2340
gtgagaacag gtgaagatgg taagttgacc tttaaaaatc tgtcagatgg gaaatatcga   2400
ttatttgaaa attctgaacc agctggttat aaacccgttc aaaataagcc tatcgttgcc   2460
ttccaaatag taaatggaga agtcagagat gtgacttcaa tcgttccaca agatatacca   2520
gcgggttacg agtttacgaa tgataagcac tatattacca atgaacctat tcctccaaag   2580
agagaatatc ctcgaactgg tggtatcgga atgttgccat tctatctgat aggttgcatg   2640
atgatgggag gagttctatt atacacacgg aaacatccg                          2679

<210>   776
<211>   893
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell wall surface anchor family protein
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Feature of note: RGD motif

<400>   776
Met Leu Asn Arg Glu Thr His Met Lys Lys Val Arg Lys Ile Phe Gln 
1               5                   10                  15      

Lys Ala Val Ala Gly Leu Cys Cys Ile Ser Gln Leu Thr Ala Phe Ser 
            20                  25                  30          

Ser Ile Val Ala Leu Ala Glu Thr Pro Glu Thr Ser Pro Ala Ile Gly 
        35                  40                  45              

Lys Val Val Ile Lys Glu Thr Gly Glu Gly Gly Ala Leu Leu Gly Asp 
    50                  55                  60                  

Ala Val Phe Glu Leu Lys Asn Asn Thr Asp Gly Thr Thr Val Ser Gln 
65                  70                  75                  80  

Arg Thr Glu Ala Gln Thr Gly Glu Ala Ile Phe Ser Asn Ile Lys Pro 
                85                  90                  95      

Gly Thr Tyr Thr Leu Thr Glu Ala Gln Pro Pro Val Gly Tyr Lys Pro 
            100                 105                 110         

Ser Thr Lys Gln Trp Thr Val Glu Val Glu Lys Asn Gly Arg Thr Thr 
        115                 120                 125             

Val Gln Gly Glu Gln Val Glu Asn Arg Glu Glu Ala Leu Ser Asp Gln 
    130                 135                 140                 

Tyr Pro Gln Thr Gly Thr Tyr Pro Asp Val Gln Thr Pro Tyr Gln Ile 
145                 150                 155                 160 

Ile Lys Val Asp Gly Ser Glu Lys Asn Gly Gln His Lys Ala Leu Asn 
                165                 170                 175     

Pro Asn Pro Tyr Glu Arg Val Ile Pro Glu Gly Thr Leu Ser Lys Arg 
            180                 185                 190         

Ile Tyr Gln Val Asn Asn Leu Asp Asp Asn Gln Tyr Gly Ile Glu Leu 
        195                 200                 205             

Thr Val Ser Gly Lys Thr Val Tyr Glu Gln Lys Asp Lys Ser Val Pro 
    210                 215                 220                 

Leu Asp Val Val Ile Leu Leu Asp Asn Ser Asn Ser Met Ser Asn Ile 
225                 230                 235                 240 

Arg Asn Lys Asn Ala Arg Arg Ala Glu Arg Ala Gly Glu Ala Thr Arg 
                245                 250                 255     

Ser Leu Ile Asp Lys Ile Thr Ser Asp Ser Glu Asn Arg Val Ala Leu 
            260                 265                 270         

Val Thr Tyr Ala Ser Thr Ile Phe Asp Gly Thr Glu Phe Thr Val Glu 
        275                 280                 285             

Lys Gly Val Ala Asp Lys Asn Gly Lys Arg Leu Asn Asp Ser Leu Phe 
    290                 295                 300                 

Trp Asn Tyr Asp Gln Thr Ser Phe Thr Thr Asn Thr Lys Asp Tyr Ser 
305                 310                 315                 320 

Tyr Leu Lys Leu Thr Asn Asp Lys Asn Asp Ile Val Glu Leu Lys Asn 
                325                 330                 335     

Lys Val Pro Thr Glu Ala Glu Asp His Asp Gly Asn Arg Leu Met Tyr 
            340                 345                 350         

Gln Phe Gly Ala Thr Phe Thr Gln Lys Ala Leu Met Lys Ala Asp Glu 
        355                 360                 365             

Ile Leu Thr Gln Gln Ala Arg Gln Asn Ser Gln Lys Val Ile Phe His 
    370                 375                 380                 

Ile Thr Asp Gly Val Pro Thr Met Ser Tyr Pro Ile Asn Phe Asn His 
385                 390                 395                 400 

Ala Thr Phe Ala Pro Ser Tyr Gln Asn Gln Leu Asn Ala Phe Phe Ser 
                405                 410                 415     

Lys Ser Pro Asn Lys Asp Gly Ile Leu Leu Ser Asp Phe Ile Thr Gln 
            420                 425                 430         

Ala Thr Ser Gly Glu His Thr Ile Val Arg Gly Asp Gly Gln Ser Tyr 
        435                 440                 445             

Gln Met Phe Thr Asp Lys Thr Val Tyr Glu Lys Gly Ala Pro Ala Ala 
    450                 455                 460                 

Phe Pro Val Lys Pro Glu Lys Tyr Ser Glu Met Lys Ala Ala Gly Tyr 
465                 470                 475                 480 

Ala Val Ile Gly Asp Pro Ile Asn Gly Gly Tyr Ile Trp Leu Asn Trp 
                485                 490                 495     

Arg Glu Ser Ile Leu Ala Tyr Pro Phe Asn Ser Asn Thr Ala Lys Ile 
            500                 505                 510         

Thr Asn His Gly Asp Pro Thr Arg Trp Tyr Tyr Asn Gly Asn Ile Ala 
        515                 520                 525             

Pro Asp Gly Tyr Asp Val Phe Thr Val Gly Ile Gly Ile Asn Gly Asp 
    530                 535                 540                 

Pro Gly Thr Asp Glu Ala Thr Ala Thr Ser Phe Met Gln Ser Ile Ser 
545                 550                 555                 560 

Ser Lys Pro Glu Asn Tyr Thr Asn Val Thr Asp Thr Thr Lys Ile Leu 
                565                 570                 575     

Glu Gln Leu Asn Arg Tyr Phe His Thr Ile Val Thr Glu Lys Lys Ser 
            580                 585                 590         

Ile Glu Asn Gly Thr Ile Thr Asp Pro Met Gly Glu Leu Ile Asp Leu 
        595                 600                 605             

Gln Leu Gly Thr Asp Gly Arg Phe Asp Pro Ala Asp Tyr Thr Leu Thr 
    610                 615                 620                 

Ala Asn Asp Gly Ser Arg Leu Glu Asn Gly Gln Ala Val Gly Gly Pro 
625                 630                 635                 640 

Gln Asn Asp Gly Gly Leu Leu Lys Asn Ala Lys Val Leu Tyr Asp Thr 
                645                 650                 655     

Thr Glu Lys Arg Ile Arg Val Thr Gly Leu Tyr Leu Gly Thr Asp Glu 
            660                 665                 670         

Lys Val Thr Leu Thr Tyr Asn Val Arg Leu Asn Asp Glu Phe Val Ser 
        675                 680                 685             

Asn Lys Phe Tyr Asp Thr Asn Gly Arg Thr Thr Leu His Pro Lys Glu 
    690                 695                 700                 

Val Glu Gln Asn Thr Val Arg Asp Phe Pro Ile Pro Lys Ile Arg Asp 
705                 710                 715                 720 

Val Arg Lys Tyr Pro Glu Ile Thr Ile Ser Lys Glu Lys Lys Leu Gly 
                725                 730                 735     

Asp Ile Glu Phe Ile Lys Val Asn Lys Asn Asp Lys Lys Pro Leu Arg 
            740                 745                 750         

Gly Ala Val Phe Ser Leu Gln Lys Gln His Pro Asp Tyr Pro Asp Ile 
        755                 760                 765             

Tyr Gly Ala Ile Asp Gln Asn Gly Thr Tyr Gln Asn Val Arg Thr Gly 
    770                 775                 780                 

Glu Asp Gly Lys Leu Thr Phe Lys Asn Leu Ser Asp Gly Lys Tyr Arg 
785                 790                 795                 800 

Leu Phe Glu Asn Ser Glu Pro Ala Gly Tyr Lys Pro Val Gln Asn Lys 
                805                 810                 815     

Pro Ile Val Ala Phe Gln Ile Val Asn Gly Glu Val Arg Asp Val Thr 
            820                 825                 830         

Ser Ile Val Pro Gln Asp Ile Pro Ala Gly Tyr Glu Phe Thr Asn Asp 
        835                 840                 845             

Lys His Tyr Ile Thr Asn Glu Pro Ile Pro Pro Lys Arg Glu Tyr Pro 
    850                 855                 860                 

Arg Thr Gly Gly Ile Gly Met Leu Pro Phe Tyr Leu Ile Gly Cys Met 
865                 870                 875                 880 

Met Met Gly Gly Val Leu Leu Tyr Thr Arg Lys His Pro 
                885                 890             

<210>   777
<211>   1995
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   777
atgaaatcaa tcaacaaatt tttaacaatg cttgctgcct tattactgac agcgagtagc   60
ctgttttcag ctgcaacagt ttttgcggct gggacgacaa caacatctgt taccgttcat   120
aaactattgg caacagatgg ggatatggat aaaattgcaa atgagttaga aacaggtaac   180
tatgctggta ataaagtggg tgttctacct gcaaatgcaa aagaaattgc cggtgttatg   240
ttcgtttgga caaatactaa taatgaaatt attgatgaaa atggccaaac tctaggagtg   300
aatattgatc cacaaacatt taaactctca ggggcaatgc cggcaactgc aatgaaaaaa   360
ttaacagaag ctgaaggagc taaatttaac acggcaaatt taccagctgc taagtataaa   420
atttatgaaa ttcacagttt atcaacttat gtcggtgaag atggagcaac cttaacaggt   480
tctaaagcag ttccaattga aattgaatta ccattgaacg atgttgtgga tgcgcatgtg   540
tatccaaaaa atacagaagc aaagccaaaa attgataaag atttcaaagg taaagcaaat   600
ccagatacac cacgtgtaga taaagataca cctgtgaacc accaagttgg agatgttgta   660
gagtacgaaa ttgttacaaa aattccagca cttgctaatt atgcaacagc aaactggagc   720
gatagaatga ctgaaggttt ggcattcaac aaaggtacag tgaaagtaac tgttgatgat   780
gttgcacttg aagcaggtga ttatgctcta acagaagtag caactggttt tgatttgaaa   840
ttaacagatg ctggtttagc taaagtgaat gaccaaaacg ctgaaaaaac tgtgaaaatc   900
acttattcgg caacattgaa tgacaaagca attgtagaag taccagaatc taatgatgta   960
acatttaact atggtaataa tccagatcac gggaatactc caaagccgaa taagccaaat   1020
gaaaacggcg atttgacatt gaccaagaca tgggttgatg ctacaggtgc accaattccg   1080
gctggagctg aagcaacgtt cgatttggtt aatgctcaga ctggtaaagt tgtacaaact   1140
gtaactttga caacagacaa aaatacagtt actgttaacg gattggataa aaatacagaa   1200
tataaattcg ttgaacgtag tataaaaggg tattcagcag attatcaaga aatcactaca   1260
gctggagaaa ttgctgtcaa gaactggaaa gacgaaaatc caaaaccact tgatccaaca   1320
gagccaaaag ttgttacata tggtaaaaag tttgtcaaag ttaatgataa agataatcgt   1380
ttagctgggg cagaatttgt aattgcaaat gctgataatg ctggtcaata tttagcacgt   1440
aaagcagata aagtgagtca agaagagaag cagttggttg ttacaacaaa ggatgcttta   1500
gatagagcag ttgctgctta taacgctctt actgcacaac aacaaactca gcaagaaaaa   1560
gagaaagttg acaaagctca agctgcttat aatgctgctg tgattgctgc caacaatgca   1620
tttgaatggg tggcagataa ggacaatgaa aatgttgtga aattagtttc tgatgcacaa   1680
ggtcgctttg aaattacagg ccttcttgca ggtacatatt acttagaaga aacaaaacag   1740
cctgctggtt atgcattact aactagccgt cagaaatttg aagtcactgc aacttcttat   1800
tcagcgactg gacaaggcat tgagtatact gctggttcag gtaaagatga cgctacaaaa   1860
gtagtcaaca aaaaaatcac tatcccacaa acgggtggta ttggtacaat tatctttgct   1920
gtagcggggg ctgcgattat gggtattgca gtgtacgcat atgttaaaaa caacaaagat   1980
gaggatcaac ttgct                                                    1995

<210>   778
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell wall surface anchor family protein
<223>   Cellular location: Peptidoglycan-bound (LPXTG)

<400>   778
Met Lys Ser Ile Asn Lys Phe Leu Thr Met Leu Ala Ala Leu Leu Leu 
1               5                   10                  15      

Thr Ala Ser Ser Leu Phe Ser Ala Ala Thr Val Phe Ala Ala Gly Thr 
            20                  25                  30          

Thr Thr Thr Ser Val Thr Val His Lys Leu Leu Ala Thr Asp Gly Asp 
        35                  40                  45              

Met Asp Lys Ile Ala Asn Glu Leu Glu Thr Gly Asn Tyr Ala Gly Asn 
    50                  55                  60                  

Lys Val Gly Val Leu Pro Ala Asn Ala Lys Glu Ile Ala Gly Val Met 
65                  70                  75                  80  

Phe Val Trp Thr Asn Thr Asn Asn Glu Ile Ile Asp Glu Asn Gly Gln 
                85                  90                  95      

Thr Leu Gly Val Asn Ile Asp Pro Gln Thr Phe Lys Leu Ser Gly Ala 
            100                 105                 110         

Met Pro Ala Thr Ala Met Lys Lys Leu Thr Glu Ala Glu Gly Ala Lys 
        115                 120                 125             

Phe Asn Thr Ala Asn Leu Pro Ala Ala Lys Tyr Lys Ile Tyr Glu Ile 
    130                 135                 140                 

His Ser Leu Ser Thr Tyr Val Gly Glu Asp Gly Ala Thr Leu Thr Gly 
145                 150                 155                 160 

Ser Lys Ala Val Pro Ile Glu Ile Glu Leu Pro Leu Asn Asp Val Val 
                165                 170                 175     

Asp Ala His Val Tyr Pro Lys Asn Thr Glu Ala Lys Pro Lys Ile Asp 
            180                 185                 190         

Lys Asp Phe Lys Gly Lys Ala Asn Pro Asp Thr Pro Arg Val Asp Lys 
        195                 200                 205             

Asp Thr Pro Val Asn His Gln Val Gly Asp Val Val Glu Tyr Glu Ile 
    210                 215                 220                 

Val Thr Lys Ile Pro Ala Leu Ala Asn Tyr Ala Thr Ala Asn Trp Ser 
225                 230                 235                 240 

Asp Arg Met Thr Glu Gly Leu Ala Phe Asn Lys Gly Thr Val Lys Val 
                245                 250                 255     

Thr Val Asp Asp Val Ala Leu Glu Ala Gly Asp Tyr Ala Leu Thr Glu 
            260                 265                 270         

Val Ala Thr Gly Phe Asp Leu Lys Leu Thr Asp Ala Gly Leu Ala Lys 
        275                 280                 285             

Val Asn Asp Gln Asn Ala Glu Lys Thr Val Lys Ile Thr Tyr Ser Ala 
    290                 295                 300                 

Thr Leu Asn Asp Lys Ala Ile Val Glu Val Pro Glu Ser Asn Asp Val 
305                 310                 315                 320 

Thr Phe Asn Tyr Gly Asn Asn Pro Asp His Gly Asn Thr Pro Lys Pro 
                325                 330                 335     

Asn Lys Pro Asn Glu Asn Gly Asp Leu Thr Leu Thr Lys Thr Trp Val 
            340                 345                 350         

Asp Ala Thr Gly Ala Pro Ile Pro Ala Gly Ala Glu Ala Thr Phe Asp 
        355                 360                 365             

Leu Val Asn Ala Gln Thr Gly Lys Val Val Gln Thr Val Thr Leu Thr 
    370                 375                 380                 

Thr Asp Lys Asn Thr Val Thr Val Asn Gly Leu Asp Lys Asn Thr Glu 
385                 390                 395                 400 

Tyr Lys Phe Val Glu Arg Ser Ile Lys Gly Tyr Ser Ala Asp Tyr Gln 
                405                 410                 415     

Glu Ile Thr Thr Ala Gly Glu Ile Ala Val Lys Asn Trp Lys Asp Glu 
            420                 425                 430         

Asn Pro Lys Pro Leu Asp Pro Thr Glu Pro Lys Val Val Thr Tyr Gly 
        435                 440                 445             

Lys Lys Phe Val Lys Val Asn Asp Lys Asp Asn Arg Leu Ala Gly Ala 
    450                 455                 460                 

Glu Phe Val Ile Ala Asn Ala Asp Asn Ala Gly Gln Tyr Leu Ala Arg 
465                 470                 475                 480 

Lys Ala Asp Lys Val Ser Gln Glu Glu Lys Gln Leu Val Val Thr Thr 
                485                 490                 495     

Lys Asp Ala Leu Asp Arg Ala Val Ala Ala Tyr Asn Ala Leu Thr Ala 
            500                 505                 510         

Gln Gln Gln Thr Gln Gln Glu Lys Glu Lys Val Asp Lys Ala Gln Ala 
        515                 520                 525             

Ala Tyr Asn Ala Ala Val Ile Ala Ala Asn Asn Ala Phe Glu Trp Val 
    530                 535                 540                 

Ala Asp Lys Asp Asn Glu Asn Val Val Lys Leu Val Ser Asp Ala Gln 
545                 550                 555                 560 

Gly Arg Phe Glu Ile Thr Gly Leu Leu Ala Gly Thr Tyr Tyr Leu Glu 
                565                 570                 575     

Glu Thr Lys Gln Pro Ala Gly Tyr Ala Leu Leu Thr Ser Arg Gln Lys 
            580                 585                 590         

Phe Glu Val Thr Ala Thr Ser Tyr Ser Ala Thr Gly Gln Gly Ile Glu 
        595                 600                 605             

Tyr Thr Ala Gly Ser Gly Lys Asp Asp Ala Thr Lys Val Val Asn Lys 
    610                 615                 620                 

Lys Ile Thr Ile Pro Gln Thr Gly Gly Ile Gly Thr Ile Ile Phe Ala 
625                 630                 635                 640 

Val Ala Gly Ala Ala Ile Met Gly Ile Ala Val Tyr Ala Tyr Val Lys 
                645                 650                 655     

Asn Asn Lys Asp Glu Asp Gln Leu Ala 
            660                 665 

<210>   779
<211>   1206
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   779
ttgatgacaa tgcagaaaat gcagaaaatg attagtcgta tcttctttgt tatggctctg   60
tgtttttctc ttgtatgggg tgcacatgca gtccaagcgc aagaagatca cacgttggtc   120
ttgcaattgg agaactatca ggaggtggtt agtcaattgc catctcgtga tggtcatcgg   180
ttgcaagtat ggaagttgga tgattcgtat tcctatgatg atcgggtgca aattgtaaga   240
gacttgcatt cgtgggatga gaataaactt tcttctttca aaaagacttc gtttgagatg   300
accttccttg agaatcagat tgaagtatct catattccaa atggtcttta ctatgttcgc   360
tctattatcc agacggatgc ggtttcttat ccagctgaat ttctttttga aatgacagat   420
caaacggtag agcctttggt cattgtagcg aaaaaaacag atacaatgac aacaaaggtg   480
aagctgataa aggtggatca agaccacaat cgcttggagg gtgtcggctt taaattggta   540
tcagtagcaa gagatgtttc tgaaaaagag gttcccttga ttggagaata ccgttacagt   600
tcttctggtc aagtagggag aactctctat actgataaaa atggagagat ttttgtgaca   660
aatcttcctc ttgggaacta tcgtttcaag gaggtggagc cactggcagg ctatgctgtt   720
acgacgctgg atacggatgt ccagctggta gatcatcagc tggtgacgat tacggttgtc   780
aatcagaaat taccacgtgg caatgttgac tttatgaagg tggatggtcg gaccaatacc   840
tctcttcaag gggcaatgtt caaagtcatg aaagaagaaa gcggacacta tactcctgtt   900
cttcaaaatg gtaaggaagt agttgtaaca tcagggaaag atggtcgttt ccgagtggaa   960
ggtctagagt atgggacata ctatttatgg gagctccaag ctccaactgg ttatgttcaa   1020
ttaacatcgc ctgtttcctt tacaatcggg aaagatactc gtaaggaact ggtaacagtg   1080
gttaaaaata acaagcgacc acggattgat gtgccagata caggggaaga aaccttgtat   1140
atcttgatgc ttgttgccat tttgttgttt ggtagtggtt attatcttac gaaaaaacca   1200
aataac                                                              1206

<210>   780
<211>   402
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell wall surface anchor family protein
<223>   Cellular location: Peptidoglycan-bound (LPXTG)

<400>   780
Met Met Thr Met Gln Lys Met Gln Lys Met Ile Ser Arg Ile Phe Phe 
1               5                   10                  15      

Val Met Ala Leu Cys Phe Ser Leu Val Trp Gly Ala His Ala Val Gln 
            20                  25                  30          

Ala Gln Glu Asp His Thr Leu Val Leu Gln Leu Glu Asn Tyr Gln Glu 
        35                  40                  45              

Val Val Ser Gln Leu Pro Ser Arg Asp Gly His Arg Leu Gln Val Trp 
    50                  55                  60                  

Lys Leu Asp Asp Ser Tyr Ser Tyr Asp Asp Arg Val Gln Ile Val Arg 
65                  70                  75                  80  

Asp Leu His Ser Trp Asp Glu Asn Lys Leu Ser Ser Phe Lys Lys Thr 
                85                  90                  95      

Ser Phe Glu Met Thr Phe Leu Glu Asn Gln Ile Glu Val Ser His Ile 
            100                 105                 110         

Pro Asn Gly Leu Tyr Tyr Val Arg Ser Ile Ile Gln Thr Asp Ala Val 
        115                 120                 125             

Ser Tyr Pro Ala Glu Phe Leu Phe Glu Met Thr Asp Gln Thr Val Glu 
    130                 135                 140                 

Pro Leu Val Ile Val Ala Lys Lys Thr Asp Thr Met Thr Thr Lys Val 
145                 150                 155                 160 

Lys Leu Ile Lys Val Asp Gln Asp His Asn Arg Leu Glu Gly Val Gly 
                165                 170                 175     

Phe Lys Leu Val Ser Val Ala Arg Asp Val Ser Glu Lys Glu Val Pro 
            180                 185                 190         

Leu Ile Gly Glu Tyr Arg Tyr Ser Ser Ser Gly Gln Val Gly Arg Thr 
        195                 200                 205             

Leu Tyr Thr Asp Lys Asn Gly Glu Ile Phe Val Thr Asn Leu Pro Leu 
    210                 215                 220                 

Gly Asn Tyr Arg Phe Lys Glu Val Glu Pro Leu Ala Gly Tyr Ala Val 
225                 230                 235                 240 

Thr Thr Leu Asp Thr Asp Val Gln Leu Val Asp His Gln Leu Val Thr 
                245                 250                 255     

Ile Thr Val Val Asn Gln Lys Leu Pro Arg Gly Asn Val Asp Phe Met 
            260                 265                 270         

Lys Val Asp Gly Arg Thr Asn Thr Ser Leu Gln Gly Ala Met Phe Lys 
        275                 280                 285             

Val Met Lys Glu Glu Ser Gly His Tyr Thr Pro Val Leu Gln Asn Gly 
    290                 295                 300                 

Lys Glu Val Val Val Thr Ser Gly Lys Asp Gly Arg Phe Arg Val Glu 
305                 310                 315                 320 

Gly Leu Glu Tyr Gly Thr Tyr Tyr Leu Trp Glu Leu Gln Ala Pro Thr 
                325                 330                 335     

Gly Tyr Val Gln Leu Thr Ser Pro Val Ser Phe Thr Ile Gly Lys Asp 
            340                 345                 350         

Thr Arg Lys Glu Leu Val Thr Val Val Lys Asn Asn Lys Arg Pro Arg 
        355                 360                 365             

Ile Asp Val Pro Asp Thr Gly Glu Glu Thr Leu Tyr Ile Leu Met Leu 
    370                 375                 380                 

Val Ala Ile Leu Leu Phe Gly Ser Gly Tyr Tyr Leu Thr Lys Lys Pro 
385                 390                 395                 400 

Asn Asn 
        

<210>   781
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   781
ttgtttttac catttttatc agcatccctt tatcttcaaa ctcatcattt tatcgctttt   60
cctaacagac aatcctatct gctaagagaa acgagaaaat ctcatttctt tctgattcac   120
catccattt                                                           129

<210>   782
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   782
Met Phe Leu Pro Phe Leu Ser Ala Ser Leu Tyr Leu Gln Thr His His 
1               5                   10                  15      

Phe Ile Ala Phe Pro Asn Arg Gln Ser Tyr Leu Leu Arg Glu Thr Arg 
            20                  25                  30          

Lys Ser His Phe Phe Leu Ile His His Pro Phe 
        35                  40              

<210>   783
<211>   912
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   783
atgctgataa aaatggtaaa aacaaaaaag caaaaacgaa ataatctcct attaggagtg   60
gtatttttca ttggaatggc ggtaatggcg tatccgctgg tgtctcgctt gtattatcga   120
gtggaatcaa atcaacaaat tgctgacttt gataaggaaa aagcaacgtt ggatgaggct   180
gacattgatg aacgaatgaa attggcacaa gccttcaatg actctttgaa taatgtagtg   240
agtggcgatc cttggtcgga agaaatgaag aaaaaagggc gagcagagta tgcacgtatg   300
ttagaaatcc atgagcggat ggggcatgtg gaaatccccg ttattgacgt ggatttgccg   360
gtttatgctg gtactgctga agaggtattg cagcaagggg ctgggcatct agagggaact   420
tctctgccga tcggaggcaa ttcgacccat gcggtgatta cggcacatac aggtttgcca   480
acagctaaga tgtttacgga tttgaccaaa cttaaagttg gggataagtt ttatgtgcac   540
aatatcaagg aagtgatggc ctatcaagtg gatcaagtaa aggtgattga gccgacgaac   600
tttgatgatt tattgattgt accaggtcat gattatgtga ccttgctgac ttgtacgcca   660
tacatgatca atacccatcg tctattggtt cgggggcatc ggataccgta cgtagcagag   720
gttgaggaag aatttattgc agcaaacaaa ctcagtcatc tctatcgcta cctgttttat   780
gtggcagttg gtttgattgt gattctttta tggattattc gacgcttgcg caagaagaaa   840
aaacaaccgg aaaaggcttt gaaggcgctg aaagcagcaa ggaaggaagt gaaggtggag   900
gatggacaac ag                                                       912

<210>   784
<211>   304
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sortase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903141 (7.E-09)

<400>   784
Met Leu Ile Lys Met Val Lys Thr Lys Lys Gln Lys Arg Asn Asn Leu 
1               5                   10                  15      

Leu Leu Gly Val Val Phe Phe Ile Gly Met Ala Val Met Ala Tyr Pro 
            20                  25                  30          

Leu Val Ser Arg Leu Tyr Tyr Arg Val Glu Ser Asn Gln Gln Ile Ala 
        35                  40                  45              

Asp Phe Asp Lys Glu Lys Ala Thr Leu Asp Glu Ala Asp Ile Asp Glu 
    50                  55                  60                  

Arg Met Lys Leu Ala Gln Ala Phe Asn Asp Ser Leu Asn Asn Val Val 
65                  70                  75                  80  

Ser Gly Asp Pro Trp Ser Glu Glu Met Lys Lys Lys Gly Arg Ala Glu 
                85                  90                  95      

Tyr Ala Arg Met Leu Glu Ile His Glu Arg Met Gly His Val Glu Ile 
            100                 105                 110         

Pro Val Ile Asp Val Asp Leu Pro Val Tyr Ala Gly Thr Ala Glu Glu 
        115                 120                 125             

Val Leu Gln Gln Gly Ala Gly His Leu Glu Gly Thr Ser Leu Pro Ile 
    130                 135                 140                 

Gly Gly Asn Ser Thr His Ala Val Ile Thr Ala His Thr Gly Leu Pro 
145                 150                 155                 160 

Thr Ala Lys Met Phe Thr Asp Leu Thr Lys Leu Lys Val Gly Asp Lys 
                165                 170                 175     

Phe Tyr Val His Asn Ile Lys Glu Val Met Ala Tyr Gln Val Asp Gln 
            180                 185                 190         

Val Lys Val Ile Glu Pro Thr Asn Phe Asp Asp Leu Leu Ile Val Pro 
        195                 200                 205             

Gly His Asp Tyr Val Thr Leu Leu Thr Cys Thr Pro Tyr Met Ile Asn 
    210                 215                 220                 

Thr His Arg Leu Leu Val Arg Gly His Arg Ile Pro Tyr Val Ala Glu 
225                 230                 235                 240 

Val Glu Glu Glu Phe Ile Ala Ala Asn Lys Leu Ser His Leu Tyr Arg 
                245                 250                 255     

Tyr Leu Phe Tyr Val Ala Val Gly Leu Ile Val Ile Leu Leu Trp Ile 
            260                 265                 270         

Ile Arg Arg Leu Arg Lys Lys Lys Lys Gln Pro Glu Lys Ala Leu Lys 
        275                 280                 285             

Ala Leu Lys Ala Ala Arg Lys Glu Val Lys Val Glu Asp Gly Gln Gln 
    290                 295                 300                 



<210>   785
<211>   147
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   785
atggattatt cgacgcttgc gcaagaagaa aaaacaaccg gaaaaggctt tgaaggcgct   60
gaaagcagca aggaaggaag tgaaggtgga ggatggacaa cagtagacgt tcacgaaaaa   120
aaggcacaaa aaagaagaaa catccgc                                       147

<210>   786
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   786
Met Asp Tyr Ser Thr Leu Ala Gln Glu Glu Lys Thr Thr Gly Lys Gly 
1               5                   10                  15      

Phe Glu Gly Ala Glu Ser Ser Lys Glu Gly Ser Glu Gly Gly Gly Trp 
            20                  25                  30          

Thr Thr Val Asp Val His Glu Lys Lys Ala Gln Lys Arg Arg Asn Ile 

        35                  40                  45              

Arg 
    

<210>   787
<211>   786
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   787
ttggtgtctc gttattatta tcgtattgag tcaaacgagg ttattaaaga gtttgatgag   60
acggtttccc agatggataa ggcagaactt gaggagcgtt ggcgcttggc tcaagccttc   120
aatgcgacct tgaaaccatc tgaaattctt gatcctttta cagagcaaga gaaaaagaaa   180
ggcgtctcag aatatgccaa tatgctaaag gtccatgagc ggattggcta tgtggaaatt   240
cctgcgattg atcaggaaat tccgatgtat gtcggaacga gtgaggacat tcttcagaaa   300
ggggcagggc tgttagaagg ggcttcgctg cctgttggag gtgaaaatac ccatacagtg   360
atcactgctc acagaggatt gccaacggca gaattgttca gtcaattgga taagatgaaa   420
aaaggggata tcttttatct tcacgtttta gatcaggtgt tggcctacca agtggatcag   480
atagtgacgg tggagccgaa tgactttgag cctgtcttga ttcaacatgg ggaagattat   540
gcgaccttgt tgacttgtac accgtatatg attaacagtc atcgtctgtt ggtacgtggg   600
aagcggattc cgtatacggc accaattgca gagcggaatc gagcggtgag agagcgtggg   660
caattctggt tgtggttatt actaggagcg atggcggtca tccttctctt gctgtatcgc   720
gtgtatcgta atcgacggat tgtcaaagga ctagaaaagc aattggaggg gcgtcatgtc   780
aaggac                                                              786

<210>   788
<211>   262
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sortase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903141 (1.E-08)

<400>   788
Met Val Ser Arg Tyr Tyr Tyr Arg Ile Glu Ser Asn Glu Val Ile Lys 
1               5                   10                  15      

Glu Phe Asp Glu Thr Val Ser Gln Met Asp Lys Ala Glu Leu Glu Glu 
            20                  25                  30          

Arg Trp Arg Leu Ala Gln Ala Phe Asn Ala Thr Leu Lys Pro Ser Glu 
        35                  40                  45              

Ile Leu Asp Pro Phe Thr Glu Gln Glu Lys Lys Lys Gly Val Ser Glu 
    50                  55                  60                  

Tyr Ala Asn Met Leu Lys Val His Glu Arg Ile Gly Tyr Val Glu Ile 
65                  70                  75                  80  

Pro Ala Ile Asp Gln Glu Ile Pro Met Tyr Val Gly Thr Ser Glu Asp 
                85                  90                  95      

Ile Leu Gln Lys Gly Ala Gly Leu Leu Glu Gly Ala Ser Leu Pro Val 
            100                 105                 110         

Gly Gly Glu Asn Thr His Thr Val Ile Thr Ala His Arg Gly Leu Pro 
        115                 120                 125             

Thr Ala Glu Leu Phe Ser Gln Leu Asp Lys Met Lys Lys Gly Asp Ile 
    130                 135                 140                 

Phe Tyr Leu His Val Leu Asp Gln Val Leu Ala Tyr Gln Val Asp Gln 
145                 150                 155                 160 

Ile Val Thr Val Glu Pro Asn Asp Phe Glu Pro Val Leu Ile Gln His 
                165                 170                 175     

Gly Glu Asp Tyr Ala Thr Leu Leu Thr Cys Thr Pro Tyr Met Ile Asn 
            180                 185                 190         

Ser His Arg Leu Leu Val Arg Gly Lys Arg Ile Pro Tyr Thr Ala Pro 
        195                 200                 205             

Ile Ala Glu Arg Asn Arg Ala Val Arg Glu Arg Gly Gln Phe Trp Leu 
    210                 215                 220                 

Trp Leu Leu Leu Gly Ala Met Ala Val Ile Leu Leu Leu Leu Tyr Arg 
225                 230                 235                 240 

Val Tyr Arg Asn Arg Arg Ile Val Lys Gly Leu Glu Lys Gln Leu Glu 
                245                 250                 255     

Gly Arg His Val Lys Asp 
            260         

<210>   789
<211>   849
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   789
atgtcaagga ctaaactacg agccttattg ggatacttgt tgatgttggt agcctgtttg   60
attcctattt attgttttgg acagatggtg ttgcagtctc ttggacaggt gaaaggtcat   120
gctacatttg tgaaatccat gacaactgaa atgtaccaag aacaacagaa ccattctctc   180
gcctacaatc aacgcttggc ttcgcaaaat cgcattgtag atcctttttt ggcggaggga   240
tatgaggtca attaccaagt gtctgacgac cctgatgcag tctatggtta cttgtctatt   300
ccaagtttgg aaatcatgga gccggtttat ttgggagcag attatcatca tttagggatg   360
ggcttggctc atgtggatgg tacaccgctg cctctggatg gtacagggat tcgctcagtg   420
attgctgggc accgtgcaga gccaagccat gtctttttcc gccatttgga tcagctaaaa   480
gttggagatg ctctttatta tgataatggc caggaaattg tagaatatca gatgatggac   540
acagagatta ttttaccgtc ggaatgggaa aaattagaat cggttagctc taaaaatatc   600
atgaccttga taacctgcga tccgattcct acctttaata aacgcttatt agtgaatttt   660
gaacgagtcg ctgtttatca aaaatcagat ccacaaacag ctgcagttgc gagggttgct   720
tttacgaaag aaggacaatc tgtatcgcgt gttgcaacct ctcaatggtt gtaccgtggg   780
ctagtggtac tggcatttct gggaatcctg tttgttttgt ggaagctagc acgtttacta   840
cgagggaaa                                                           849

<210>   790
<211>   283
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sortase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903141 (1.E-05)

<400>   790
Met Ser Arg Thr Lys Leu Arg Ala Leu Leu Gly Tyr Leu Leu Met Leu 
1               5                   10                  15      

Val Ala Cys Leu Ile Pro Ile Tyr Cys Phe Gly Gln Met Val Leu Gln 
            20                  25                  30          

Ser Leu Gly Gln Val Lys Gly His Ala Thr Phe Val Lys Ser Met Thr 
        35                  40                  45              

Thr Glu Met Tyr Gln Glu Gln Gln Asn His Ser Leu Ala Tyr Asn Gln 
    50                  55                  60                  

Arg Leu Ala Ser Gln Asn Arg Ile Val Asp Pro Phe Leu Ala Glu Gly 
65                  70                  75                  80  

Tyr Glu Val Asn Tyr Gln Val Ser Asp Asp Pro Asp Ala Val Tyr Gly 
                85                  90                  95      

Tyr Leu Ser Ile Pro Ser Leu Glu Ile Met Glu Pro Val Tyr Leu Gly 
            100                 105                 110         

Ala Asp Tyr His His Leu Gly Met Gly Leu Ala His Val Asp Gly Thr 
        115                 120                 125             

Pro Leu Pro Leu Asp Gly Thr Gly Ile Arg Ser Val Ile Ala Gly His 
    130                 135                 140                 

Arg Ala Glu Pro Ser His Val Phe Phe Arg His Leu Asp Gln Leu Lys 
145                 150                 155                 160 

Val Gly Asp Ala Leu Tyr Tyr Asp Asn Gly Gln Glu Ile Val Glu Tyr 
                165                 170                 175     

Gln Met Met Asp Thr Glu Ile Ile Leu Pro Ser Glu Trp Glu Lys Leu 
            180                 185                 190         

Glu Ser Val Ser Ser Lys Asn Ile Met Thr Leu Ile Thr Cys Asp Pro 
        195                 200                 205             

Ile Pro Thr Phe Asn Lys Arg Leu Leu Val Asn Phe Glu Arg Val Ala 
    210                 215                 220                 

Val Tyr Gln Lys Ser Asp Pro Gln Thr Ala Ala Val Ala Arg Val Ala 
225                 230                 235                 240 

Phe Thr Lys Glu Gly Gln Ser Val Ser Arg Val Ala Thr Ser Gln Trp 
                245                 250                 255     

Leu Tyr Arg Gly Leu Val Val Leu Ala Phe Leu Gly Ile Leu Phe Val 
            260                 265                 270         

Leu Trp Lys Leu Ala Arg Leu Leu Arg Gly Lys 
        275                 280             

<210>   791
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   791
gtgctagctt ccacaaaaca aacaggattc ccagaaatgc cagtaccact agcccacggt   60
acaaccattg agaggttgca acacgcgata cagattgtcc ttctttcg                108

<210>   792
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   792
Met Leu Ala Ser Thr Lys Gln Thr Gly Phe Pro Glu Met Pro Val Pro 
1               5                   10                  15      

Leu Ala His Gly Thr Thr Ile Glu Arg Leu Gln His Ala Ile Gln Ile 
            20                  25                  30          

Val Leu Leu Ser 
        35      

<210>   793
<211>   759
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   793
atgagcttta ttgcgcaaga ttttgaaaag ctcgatatca tcactgttct tgaaggtaga   60
acacaagctg tcatccgaga tcactttctt aaatatgata gagccgtccg atgtcgcgtc   120
aaaattatta ctatggatat gtttagtcct tactatgact tagctagaca acttttcccg   180
tgtgctaaaa tcgttcttga tcgctttcac attgtacaac atcttagccg tgctatgagt   240
cgtgtgcgtg tccaaatcat gaatcagttt catcgaaaat cccatgaata caaggctatc   300
aagcgctact ggaaactcat tcaacaggat agccgtaaac tcagcgataa acatttttat   360
cgccctactt ttcgtatgca tttaaccaat aaagagattt tagacaagct tttgagctat   420
tcacaagact tgaaacatca ctatcagctc tatcaactct tgctgtttca ctttcagaat   480
aaggaaccgg agaaattttt cgaacttatc gaggacaatc ttaagcaggt tcatcctatt   540
tttcagactg tctttaaaac cttcctcaaa gataaagaaa aggttatcaa cgcccttcaa   600
ctacactatt ctaatgccaa actggaagcg accaataatc tcatcaaact tatcaagcgc   660
aatgcctttg gttttcgaaa ctttgaaaac ttcaaaaaac ggatttttat cgctctgaat   720
atcaaaaaag aaaggacaaa atttgtcctt tctcgagct                          759

<210>   794
<211>   253
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   794
Met Ser Phe Ile Ala Gln Asp Phe Glu Lys Leu Asp Ile Ile Thr Val 
1               5                   10                  15      

Leu Glu Gly Arg Thr Gln Ala Val Ile Arg Asp His Phe Leu Lys Tyr 
            20                  25                  30          

Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile Thr Met Asp Met Phe 
        35                  40                  45              

Ser Pro Tyr Tyr Asp Leu Ala Arg Gln Leu Phe Pro Cys Ala Lys Ile 
    50                  55                  60                  

Val Leu Asp Arg Phe His Ile Val Gln His Leu Ser Arg Ala Met Ser 
65                  70                  75                  80  

Arg Val Arg Val Gln Ile Met Asn Gln Phe His Arg Lys Ser His Glu 
                85                  90                  95      

Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile Gln Gln Asp Ser Arg 
            100                 105                 110         

Lys Leu Ser Asp Lys His Phe Tyr Arg Pro Thr Phe Arg Met His Leu 
        115                 120                 125             

Thr Asn Lys Glu Ile Leu Asp Lys Leu Leu Ser Tyr Ser Gln Asp Leu 
    130                 135                 140                 

Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu Phe His Phe Gln Asn 
145                 150                 155                 160 

Lys Glu Pro Glu Lys Phe Phe Glu Leu Ile Glu Asp Asn Leu Lys Gln 
                165                 170                 175     

Val His Pro Ile Phe Gln Thr Val Phe Lys Thr Phe Leu Lys Asp Lys 
            180                 185                 190         

Glu Lys Val Ile Asn Ala Leu Gln Leu His Tyr Ser Asn Ala Lys Leu 
        195                 200                 205             

Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys Arg Asn Ala Phe Gly 
    210                 215                 220                 

Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile Phe Ile Ala Leu Asn 
225                 230                 235                 240 

Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser Arg Ala 
                245                 250             

<210>   795
<211>   1274
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   795
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accgtctaag   180
atcccttacc tcgaaacaac tggtatgcct tctagaattc tccttagaaa acgccgtttc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ctatcgtcaa gaagaatcat   300
caaattcctc gtattatcaa ccaaaaaatt gcgcaaaagt tgattgagaa gatttctatg   360
accgatattg ctcatcagct ggccatttca acttcaactg tcattcgcaa gctcaatgat   420
tctcactttg agcatgattt ttcgcgtctt cctgagatta tgtcctggga cgttgaaaca   480
gtccggggag tgactgtttc aatcgggaga tggagatgag ctttattgcg caagattttg   540
aaaagctcga tatcatcact gttcttgaag gtagaacaca agctgtcatc cgagatcact   600
ttcttaaata tgatagagcc gtccgatgtc gcgtcaaaat tattactatg gatatgttta   660
gtccttacta tgacttagct agacaacttt tcccgtgtgc taaaatcgtt cttgatcgct   720
ttcacattgt acaacatctt agccgtgcta tgagtcgtgt gcgtgtccaa atcatgaatc   780
agtttcatcg aaaatcccat gaatacaagg ctatcaagcg ctactggaaa ctcattcaac   840
aggatagccg taaactcagc gataaacatt tttatcgccc tacttttcgt atgcatttaa   900
ccaataaaga gattttagac aagcttttga gctattcaca agacttgaaa catcactatc   960
agctctatca actcttgctg tttcactttc agaataagga accggagaaa tttttcgaac   1020
ttatcgagga caatcttaag caggttcatc ctatttttca gactgtcttt aaaaccttcc   1080
tcaaagataa agaaaaggtt atcaacgccc ttcaactaca ctattctaat gccaaactgg   1140
aagcgaccaa taatctcatc aaacttatca agcgcaatgc ctttggtttt cgaaactttg   1200
aaaacttcaa aaaacggatt tttatcgctc tgaatatcaa aaaagaaagg acaaaatttg   1260
tcctttctcg agct                                                     1274

<210>   796
<211>   172
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase FRAMESHIFT

<400>   796
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Ser Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ala 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Ser His Phe Glu 
    130                 135                 140                 

His Asp Phe Ser Arg Leu Pro Glu Ile Met Ser Trp Asp Val Glu Thr 
145                 150                 155                 160 

Val Arg Gly Val Thr Val Ser Ile Gly Arg Trp Arg 
                165                 170         

<210>   797
<211>   147
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   797
atggataaaa tgaaaccggt cttccaagcc ctaaataagg aattaattca ggaaaatctg   60
actttaacaa ttatctgtgt cggtggttat gtcttagaat atcatggttt acgtgccaca   120
caagatgttg atgcttttat ggctcta                                       147

<210>   798
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   798
Met Asp Lys Met Lys Pro Val Phe Gln Ala Leu Asn Lys Glu Leu Ile 
1               5                   10                  15      

Gln Glu Asn Leu Thr Leu Thr Ile Ile Cys Val Gly Gly Tyr Val Leu 
            20                  25                  30          

Glu Tyr His Gly Leu Arg Ala Thr Gln Asp Val Asp Ala Phe Met Ala 
        35                  40                  45              

Leu 
    

<210>   799
<211>   282
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   799
atggattggt acgattatat gatacaggca tccaaacaat cacaattcaa cgcaagccat   60
tggtttcgct atttgcgaaa agttattttt gaagactatt cttatttaac aaaccaagat   120
gtagaaaagt tgctagactc caaagaacta acccgttttc aaaaaattag cttgaagtat   180
gcctttcaag agcatactcc aactcataaa tatgtgattt cattaaataa acctgctaag   240
ttaaccaatg ttcaaaaatt gatggagaaa tacaaacatg ga                      282

<210>   800
<211>   94
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902461 (9.E-53)

<400>   800
Met Asp Trp Tyr Asp Tyr Met Ile Gln Ala Ser Lys Gln Ser Gln Phe 
1               5                   10                  15      

Asn Ala Ser His Trp Phe Arg Tyr Leu Arg Lys Val Ile Phe Glu Asp 
            20                  25                  30          

Tyr Ser Tyr Leu Thr Asn Gln Asp Val Glu Lys Leu Leu Asp Ser Lys 
        35                  40                  45              

Glu Leu Thr Arg Phe Gln Lys Ile Ser Leu Lys Tyr Ala Phe Gln Glu 
    50                  55                  60                  

His Thr Pro Thr His Lys Tyr Val Ile Ser Leu Asn Lys Pro Ala Lys 
65                  70                  75                  80  

Leu Thr Asn Val Gln Lys Leu Met Glu Lys Tyr Lys His Gly 
                85                  90                  

<210>   801
<211>   171
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   801
ttgcttatta tcaatcgttt ttttagctta tttgtcttag attggtatag aactgagcta   60
tggattaata ctcttgtatc ttatcctgtt cctaaatatg ttggtagaaa aatgaagcag   120
ttgttacgag tgtctgtatt ggaaaaaatt ttgtctatag aattctttaa a            171

<210>   802
<211>   57
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902462 (2.E-23)

<400>   802
Met Leu Ile Ile Asn Arg Phe Phe Ser Leu Phe Val Leu Asp Trp Tyr 
1               5                   10                  15      

Arg Thr Glu Leu Trp Ile Asn Thr Leu Val Ser Tyr Pro Val Pro Lys 
            20                  25                  30          

Tyr Val Gly Arg Lys Met Lys Gln Leu Leu Arg Val Ser Val Leu Glu 
        35                  40                  45              

Lys Ile Leu Ser Ile Glu Phe Phe Lys 
    50                  55          

<210>   803
<211>   1221
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   803
atgattacaa aacaatcagc ctttttacaa aatagagcca ctatactgga gtttctatat   60
cgaaatccag caacatcccg tacagatatt gttaatgaaa caggacttac tccagcaaca   120
acgactaaca tcataaaaga gctaagcgaa cagtccctca tatacgaaac tggtgatgaa   180
tttagcgagt tttccggatc tggaagacgt agaaaaacta tttctatcac agataatatt   240
ccgtatgttg ttggaggtat tgaaataaac gtcctaggta tctttctcag tctatgtgac   300
ttacaaggga aaactctttt cgagacagaa attttgaatg aagattatcc tatttcagaa   360
atcaattcca ccattaccaa tatgataaaa acagctatag agtacgtccc tttggaaaca   420
aaattacttg gatttggctt atcaatacct ggacattata acaaagactc cggaagtatc   480
attacaaaca accccatatg ggaatctttt aatttattaa atgtaattaa aagattcaat   540
tttcctttta ttgtaaaaaa taatatcgat tgtatggcta taggacaata cctttttaat   600
ccacacaata cccccgataa ctttattttc ctacacgctg gattaggtat ttacacttcc   660
tttttcacaa aagaaaaaat aggagcctct aaaaatcctt atatcggaga aattggacac   720
accattgtcg aattgaatgg gcaatattgt gaatgcggaa aaaaaggttg tttacaaaca   780
tatatttcgg atgcttggtt aatcaaacac gcccaattat tatttaaaaa ttcccaacta   840
actgtactaa aaagccttgt aaagactgaa aaagacattc atttagacac ccttttaacg   900
gcttataatt taggcgactc cgctttacgt caacaaattg ataaaggagt caatttatta   960
gccacttcta ttgcaaatct cctcctcatc aatcctgctg ataaaatcta tatcaacagt   1020
caattgctta attatcaacc tttcactcat gaagtcaggg ataaaatcca agaccagctc   1080
cacttcgttc cctttactcg taatatagaa attgaaattt taccttacaa caaacatcgt   1140
ggaagtatag gagcttgtgc attagctatc gtcgcttttt tcatagaaca tagcaatgta   1200
ttacaagata ttatttcacc t                                             1221

<210>   804
<211>   407
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ROK family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902464 (0.E+01)

<400>   804
Met Ile Thr Lys Gln Ser Ala Phe Leu Gln Asn Arg Ala Thr Ile Leu 
1               5                   10                  15      

Glu Phe Leu Tyr Arg Asn Pro Ala Thr Ser Arg Thr Asp Ile Val Asn 
            20                  25                  30          

Glu Thr Gly Leu Thr Pro Ala Thr Thr Thr Asn Ile Ile Lys Glu Leu 
        35                  40                  45              

Ser Glu Gln Ser Leu Ile Tyr Glu Thr Gly Asp Glu Phe Ser Glu Phe 
    50                  55                  60                  

Ser Gly Ser Gly Arg Arg Arg Lys Thr Ile Ser Ile Thr Asp Asn Ile 
65                  70                  75                  80  

Pro Tyr Val Val Gly Gly Ile Glu Ile Asn Val Leu Gly Ile Phe Leu 
                85                  90                  95      

Ser Leu Cys Asp Leu Gln Gly Lys Thr Leu Phe Glu Thr Glu Ile Leu 
            100                 105                 110         

Asn Glu Asp Tyr Pro Ile Ser Glu Ile Asn Ser Thr Ile Thr Asn Met 
        115                 120                 125             

Ile Lys Thr Ala Ile Glu Tyr Val Pro Leu Glu Thr Lys Leu Leu Gly 
    130                 135                 140                 

Phe Gly Leu Ser Ile Pro Gly His Tyr Asn Lys Asp Ser Gly Ser Ile 
145                 150                 155                 160 

Ile Thr Asn Asn Pro Ile Trp Glu Ser Phe Asn Leu Leu Asn Val Ile 
                165                 170                 175     

Lys Arg Phe Asn Phe Pro Phe Ile Val Lys Asn Asn Ile Asp Cys Met 
            180                 185                 190         

Ala Ile Gly Gln Tyr Leu Phe Asn Pro His Asn Thr Pro Asp Asn Phe 
        195                 200                 205             

Ile Phe Leu His Ala Gly Leu Gly Ile Tyr Thr Ser Phe Phe Thr Lys 
    210                 215                 220                 

Glu Lys Ile Gly Ala Ser Lys Asn Pro Tyr Ile Gly Glu Ile Gly His 
225                 230                 235                 240 

Thr Ile Val Glu Leu Asn Gly Gln Tyr Cys Glu Cys Gly Lys Lys Gly 
                245                 250                 255     

Cys Leu Gln Thr Tyr Ile Ser Asp Ala Trp Leu Ile Lys His Ala Gln 
            260                 265                 270         

Leu Leu Phe Lys Asn Ser Gln Leu Thr Val Leu Lys Ser Leu Val Lys 
        275                 280                 285             

Thr Glu Lys Asp Ile His Leu Asp Thr Leu Leu Thr Ala Tyr Asn Leu 
    290                 295                 300                 

Gly Asp Ser Ala Leu Arg Gln Gln Ile Asp Lys Gly Val Asn Leu Leu 
305                 310                 315                 320 

Ala Thr Ser Ile Ala Asn Leu Leu Leu Ile Asn Pro Ala Asp Lys Ile 
                325                 330                 335     

Tyr Ile Asn Ser Gln Leu Leu Asn Tyr Gln Pro Phe Thr His Glu Val 
            340                 345                 350         

Arg Asp Lys Ile Gln Asp Gln Leu His Phe Val Pro Phe Thr Arg Asn 
        355                 360                 365             

Ile Glu Ile Glu Ile Leu Pro Tyr Asn Lys His Arg Gly Ser Ile Gly 
    370                 375                 380                 


Ala Cys Ala Leu Ala Ile Val Ala Phe Phe Ile Glu His Ser Asn Val 
385                 390                 395                 400 

Leu Gln Asp Ile Ile Ser Pro 
                405         

<210>   805
<211>   1323
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   805
gtgatgaaca atattttagc gtttttagaa acaaaagtcg ctccgtttgg tgaaaaagtt   60
ggcaaccaac ggcatttgaa agctattcgt gaaggattta tgatggcaat gcctttgatt   120
ttagtcggct ctttatttct tattctaatc agttggcctc aagaggcttt tacaaattgg   180
ctgaatagtg ttggattgct aagtatcttg acaactatga atcagtcaac agtagcgatt   240
atctccttgg tcgcttgttt cggtattgcc tacaggttgt cggaaggata tggtacagat   300
ggtccgtcgg cagggatcat agccttatcc agttttgtat tgatggcacc tcgtttttcg   360
agtatggttt atgataaaaa tggggagcag gtcaagcagt tatttggcgg cgcaatacca   420
ttttctagcc tgaatgcatc ttctttgttt atggcgatta ctattggatt ggttacagca   480
gagatttatc gtatgtttat ccagcgcgga attacgataa aaatgccaag tggtgtccca   540
gatgtagtaa gtaaatcatt ttcagctctt ttatctggtt ttactacttt tgttttgtgg   600
gctttggtct taaaaggtct tgaagcggca ggagttgcag gaggtctcaa cggactccta   660
ggtgcaattg ttggaacacc gcttaagtta attgcaggaa cgcttccagg tatgattcta   720
tgtgttattg taaactcatt cttttggttc tgtggagtta atgggggaca agttttaaat   780
gcttttgtag acccagtttg gttacaattt actacagaaa accaagaagc tgtggctgca   840
ggacaaacac tccaacacat tattacatta ccgtttaaag atttatttgt atttattggt   900
ggcggtggag cgactattgg tcttgcgatt tgtctcttcc tatttagtaa gagtcgtgcg   960
aataaaacat taggtaagct agctattata ccgtctattt ttaatatcaa tacagctatt   1020
ctatttacgt ttccaacagt tttaaatccg attatgctga ttccgtttat tgctactcct   1080
acaatcaatg ccttgattac ctatgtatca atggctgtag gattagtacc ctatacaaca   1140
ggtgtaatcc ttccgtggac aatgccaccg attataggag gcttccttgc aacaggggct   1200
agttggcgag gagctctatt acaagttgtt ttgattttgg tttctgtagc aatttattat   1260
ccattcttca aaattgcaga taaacgcaat cttgaaaaag aaaaagctac tgttggaggg   1320
aaa                                                                 1323

<210>   806
<211>   441
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, cellobiose-specific IIC component (licC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902465 (0.E+01)

<400>   806
Met Met Asn Asn Ile Leu Ala Phe Leu Glu Thr Lys Val Ala Pro Phe 
1               5                   10                  15      

Gly Glu Lys Val Gly Asn Gln Arg His Leu Lys Ala Ile Arg Glu Gly 
            20                  25                  30          

Phe Met Met Ala Met Pro Leu Ile Leu Val Gly Ser Leu Phe Leu Ile 
        35                  40                  45              

Leu Ile Ser Trp Pro Gln Glu Ala Phe Thr Asn Trp Leu Asn Ser Val 
    50                  55                  60                  

Gly Leu Leu Ser Ile Leu Thr Thr Met Asn Gln Ser Thr Val Ala Ile 
65                  70                  75                  80  

Ile Ser Leu Val Ala Cys Phe Gly Ile Ala Tyr Arg Leu Ser Glu Gly 
                85                  90                  95      

Tyr Gly Thr Asp Gly Pro Ser Ala Gly Ile Ile Ala Leu Ser Ser Phe 
            100                 105                 110         

Val Leu Met Ala Pro Arg Phe Ser Ser Met Val Tyr Asp Lys Asn Gly 
        115                 120                 125             

Glu Gln Val Lys Gln Leu Phe Gly Gly Ala Ile Pro Phe Ser Ser Leu 
    130                 135                 140                 

Asn Ala Ser Ser Leu Phe Met Ala Ile Thr Ile Gly Leu Val Thr Ala 
145                 150                 155                 160 

Glu Ile Tyr Arg Met Phe Ile Gln Arg Gly Ile Thr Ile Lys Met Pro 
                165                 170                 175     

Ser Gly Val Pro Asp Val Val Ser Lys Ser Phe Ser Ala Leu Leu Ser 
            180                 185                 190         

Gly Phe Thr Thr Phe Val Leu Trp Ala Leu Val Leu Lys Gly Leu Glu 
        195                 200                 205             

Ala Ala Gly Val Ala Gly Gly Leu Asn Gly Leu Leu Gly Ala Ile Val 
    210                 215                 220                 

Gly Thr Pro Leu Lys Leu Ile Ala Gly Thr Leu Pro Gly Met Ile Leu 
225                 230                 235                 240 

Cys Val Ile Val Asn Ser Phe Phe Trp Phe Cys Gly Val Asn Gly Gly 
                245                 250                 255     

Gln Val Leu Asn Ala Phe Val Asp Pro Val Trp Leu Gln Phe Thr Thr 
            260                 265                 270         

Glu Asn Gln Glu Ala Val Ala Ala Gly Gln Thr Leu Gln His Ile Ile 
        275                 280                 285             

Thr Leu Pro Phe Lys Asp Leu Phe Val Phe Ile Gly Gly Gly Gly Ala 
    290                 295                 300                 

Thr Ile Gly Leu Ala Ile Cys Leu Phe Leu Phe Ser Lys Ser Arg Ala 
305                 310                 315                 320 

Asn Lys Thr Leu Gly Lys Leu Ala Ile Ile Pro Ser Ile Phe Asn Ile 
                325                 330                 335     

Asn Thr Ala Ile Leu Phe Thr Phe Pro Thr Val Leu Asn Pro Ile Met 
            340                 345                 350         

Leu Ile Pro Phe Ile Ala Thr Pro Thr Ile Asn Ala Leu Ile Thr Tyr 
        355                 360                 365             

Val Ser Met Ala Val Gly Leu Val Pro Tyr Thr Thr Gly Val Ile Leu 
    370                 375                 380                 

Pro Trp Thr Met Pro Pro Ile Ile Gly Gly Phe Leu Ala Thr Gly Ala 
385                 390                 395                 400 

Ser Trp Arg Gly Ala Leu Leu Gln Val Val Leu Ile Leu Val Ser Val 
                405                 410                 415     

Ala Ile Tyr Tyr Pro Phe Phe Lys Ile Ala Asp Lys Arg Asn Leu Glu 
            420                 425                 430         

Lys Glu Lys Ala Thr Val Gly Gly Lys 
        435                 440     

<210>   807
<211>   1938
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   807
ttgcagataa acgcaatctt gaaaaagaaa aagctactgt tggagggaaa taagatggtt   60
atcagagtat ttgatcaaca gaaaaatact tattctagct ttgccttaga ggaattaagt   120
tactatatga atcgggtctt taagactaac atagagcttg tcgaggagaa ggaagcggat   180
atttttgtag gattagtcaa taaagaggac agaaaagacc atgttcttat ctcattagac   240
aagggtaagg ggagaattga gtctaataca attgtaggtt tacttattgg aatttaccga   300
atgtttcatg aatttggggt tgtgtatact agaccagggc gcagacatga ctttgttcca   360
gagttacgat ttgaagattt tttagataaa cagctatcta tagatgaaac agccagttac   420
tatcataggg gagtatgtat agagggagcg gattcatttg aaaatatact agatttcatt   480
gattggctac ctaagattgg gatgaacagt tttttcatcc agtttgaaaa tccttactct   540
tttttgaaac gttggtatga acatgaattt aatccatatc taaataaaga acaattttca   600
aatgaattag tacaagaatt gagtgatagg ttggataaag aattgcaaaa aagaggtctt   660
attcatcatc gtgttggtca tggatggaca ggtgaagttt taggttactc ttcaaaattt   720
ggctgggaat caggtcttag tatttcagag gagaagaaac cctatgtcgc tgaaataaac   780
gggaaacgag aattgtttaa tacggctccg attttaacca gcctggattt ttcaaatcca   840
gatgtagctg ataagatggt agaaattatc aaggattatg ccaagaaaag acctgatgtt   900
aactacttac atgtatggtt gtcggatgct cgtaataata tttgtgaatg cgaaaactgt   960
agacaagaat tggtttcgga tcagtatatt cgtattctca atcaattgga tagggcttta   1020
acgagtgagg gattagatac aaagatttgt tttctgcttt atcatgagtt gttatgggca   1080
cctcagaaag aaaaattaga taatcctgaa cgctttacca tgatgtttgc accgattaca   1140
agaacatttg aaatgagtta tgcagatgta gattttgaca attccatacc tacgcctaaa   1200
ccttatatgc gtaataaaat tatacttccg aattctcttg aggaaaattt atcttatctt   1260
tttgagtggc aaaaagcatt taaaggagat agtttcgtat atgactatcc tttagggcgt   1320
gctcattatg gcgatttagg ctatatgaaa attagtcaaa ctatttacag agatgtatct   1380
tatctttcca acctacattt gaacgggtac atttcgtgtc aagaattacg tgccggattc   1440
cctcataatt ttcctaatta tgtcatgggg gaaatgctct ggaagaagac aagaagttat   1500
gaagaattga ttgaagaata cttttctgct ttgtatgggg aaaattggca gtctgttgtt   1560
gaatatttag aaaaattatc catttattcc tcttgtgatt attttaatgc aattggcagc   1620
cgtcaaagtg atgttttagc gaatcattat tatatagctt acaatctagc tgataatttt   1680
ttaccaatta ttgaggaaaa tatttctaag ttattaaata gtcaaaagga tgaatggaaa   1740
cagctcagtt atcatcgtga atatgttgtt aagatggcga aggctttata tcttcaagca   1800
actggaaaaa caaggcaagc tcaagatgaa tggagaaatg tgttgaatta tatccgtggg   1860
cacgaattgc tatttcaatc taatttggat gtttatcgtg taattgaagt agcaaaaaat   1920
tacgctggtt tccactta                                                 1938

<210>   808
<211>   646
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902466 (0.E+01)

<400>   808
Met Gln Ile Asn Ala Ile Leu Lys Lys Lys Lys Leu Leu Leu Glu Gly 
1               5                   10                  15      

Asn Lys Met Val Ile Arg Val Phe Asp Gln Gln Lys Asn Thr Tyr Ser 
            20                  25                  30          

Ser Phe Ala Leu Glu Glu Leu Ser Tyr Tyr Met Asn Arg Val Phe Lys 
        35                  40                  45              

Thr Asn Ile Glu Leu Val Glu Glu Lys Glu Ala Asp Ile Phe Val Gly 
    50                  55                  60                  

Leu Val Asn Lys Glu Asp Arg Lys Asp His Val Leu Ile Ser Leu Asp 
65                  70                  75                  80  

Lys Gly Lys Gly Arg Ile Glu Ser Asn Thr Ile Val Gly Leu Leu Ile 
                85                  90                  95      

Gly Ile Tyr Arg Met Phe His Glu Phe Gly Val Val Tyr Thr Arg Pro 
            100                 105                 110         

Gly Arg Arg His Asp Phe Val Pro Glu Leu Arg Phe Glu Asp Phe Leu 
        115                 120                 125             

Asp Lys Gln Leu Ser Ile Asp Glu Thr Ala Ser Tyr Tyr His Arg Gly 
    130                 135                 140                 

Val Cys Ile Glu Gly Ala Asp Ser Phe Glu Asn Ile Leu Asp Phe Ile 
145                 150                 155                 160 

Asp Trp Leu Pro Lys Ile Gly Met Asn Ser Phe Phe Ile Gln Phe Glu 
                165                 170                 175     

Asn Pro Tyr Ser Phe Leu Lys Arg Trp Tyr Glu His Glu Phe Asn Pro 
            180                 185                 190         

Tyr Leu Asn Lys Glu Gln Phe Ser Asn Glu Leu Val Gln Glu Leu Ser 
        195                 200                 205             

Asp Arg Leu Asp Lys Glu Leu Gln Lys Arg Gly Leu Ile His His Arg 
    210                 215                 220                 

Val Gly His Gly Trp Thr Gly Glu Val Leu Gly Tyr Ser Ser Lys Phe 
225                 230                 235                 240 

Gly Trp Glu Ser Gly Leu Ser Ile Ser Glu Glu Lys Lys Pro Tyr Val 
                245                 250                 255     

Ala Glu Ile Asn Gly Lys Arg Glu Leu Phe Asn Thr Ala Pro Ile Leu 
            260                 265                 270         

Thr Ser Leu Asp Phe Ser Asn Pro Asp Val Ala Asp Lys Met Val Glu 
        275                 280                 285             

Ile Ile Lys Asp Tyr Ala Lys Lys Arg Pro Asp Val Asn Tyr Leu His 
    290                 295                 300                 

Val Trp Leu Ser Asp Ala Arg Asn Asn Ile Cys Glu Cys Glu Asn Cys 
305                 310                 315                 320 

Arg Gln Glu Leu Val Ser Asp Gln Tyr Ile Arg Ile Leu Asn Gln Leu 
                325                 330                 335     

Asp Arg Ala Leu Thr Ser Glu Gly Leu Asp Thr Lys Ile Cys Phe Leu 
            340                 345                 350         

Leu Tyr His Glu Leu Leu Trp Ala Pro Gln Lys Glu Lys Leu Asp Asn 
        355                 360                 365             

Pro Glu Arg Phe Thr Met Met Phe Ala Pro Ile Thr Arg Thr Phe Glu 
    370                 375                 380                 

Met Ser Tyr Ala Asp Val Asp Phe Asp Asn Ser Ile Pro Thr Pro Lys 
385                 390                 395                 400 

Pro Tyr Met Arg Asn Lys Ile Ile Leu Pro Asn Ser Leu Glu Glu Asn 
                405                 410                 415     

Leu Ser Tyr Leu Phe Glu Trp Gln Lys Ala Phe Lys Gly Asp Ser Phe 
            420                 425                 430         

Val Tyr Asp Tyr Pro Leu Gly Arg Ala His Tyr Gly Asp Leu Gly Tyr 
        435                 440                 445             

Met Lys Ile Ser Gln Thr Ile Tyr Arg Asp Val Ser Tyr Leu Ser Asn 
    450                 455                 460                 

Leu His Leu Asn Gly Tyr Ile Ser Cys Gln Glu Leu Arg Ala Gly Phe 
465                 470                 475                 480 

Pro His Asn Phe Pro Asn Tyr Val Met Gly Glu Met Leu Trp Lys Lys 
                485                 490                 495     

Thr Arg Ser Tyr Glu Glu Leu Ile Glu Glu Tyr Phe Ser Ala Leu Tyr 
            500                 505                 510         

Gly Glu Asn Trp Gln Ser Val Val Glu Tyr Leu Glu Lys Leu Ser Ile 
        515                 520                 525             

Tyr Ser Ser Cys Asp Tyr Phe Asn Ala Ile Gly Ser Arg Gln Ser Asp 
    530                 535                 540                 

Val Leu Ala Asn His Tyr Tyr Ile Ala Tyr Asn Leu Ala Asp Asn Phe 
545                 550                 555                 560 

Leu Pro Ile Ile Glu Glu Asn Ile Ser Lys Leu Leu Asn Ser Gln Lys 
                565                 570                 575     

Asp Glu Trp Lys Gln Leu Ser Tyr His Arg Glu Tyr Val Val Lys Met 
            580                 585                 590         

Ala Lys Ala Leu Tyr Leu Gln Ala Thr Gly Lys Thr Arg Gln Ala Gln 
        595                 600                 605             

Asp Glu Trp Arg Asn Val Leu Asn Tyr Ile Arg Gly His Glu Leu Leu 
    610                 615                 620                 

Phe Gln Ser Asn Leu Asp Val Tyr Arg Val Ile Glu Val Ala Lys Asn 
625                 630                 635                 640 

Tyr Ala Gly Phe His Leu 
                645     

<210>   809
<211>   342
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   809
atgaaatcaa aagaagaaat aaatatgctt ggttttacaa ttgtcgctta cgcaggagat   60
gcaaggtcag atttgatgga tgctttggcg tttgcgagag atggatattt tgaacaggca   120
agagaattgg ttgagtctgc aaacgactca atagtgtctg cccatcgaga acagactaat   180
ttattagcgg aggaggcata tggagataat tttgaagtga gctttattat gattcatggt   240
caagatactt tgatgacaac gatgctattg tatgatcagg taaagttttt tattgatgaa   300
tatgaacgaa ttcgaaagat tgaagaacat attggtttgc aa                      342

<210>   810
<211>   114
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, lactose-specific IIA component (lacF)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902467 (4.E-61)

<400>   810
Met Lys Ser Lys Glu Glu Ile Asn Met Leu Gly Phe Thr Ile Val Ala 
1               5                   10                  15      

Tyr Ala Gly Asp Ala Arg Ser Asp Leu Met Asp Ala Leu Ala Phe Ala 
            20                  25                  30          

Arg Asp Gly Tyr Phe Glu Gln Ala Arg Glu Leu Val Glu Ser Ala Asn 
        35                  40                  45              

Asp Ser Ile Val Ser Ala His Arg Glu Gln Thr Asn Leu Leu Ala Glu 
    50                  55                  60                  

Glu Ala Tyr Gly Asp Asn Phe Glu Val Ser Phe Ile Met Ile His Gly 
65                  70                  75                  80  

Gln Asp Thr Leu Met Thr Thr Met Leu Leu Tyr Asp Gln Val Lys Phe 
                85                  90                  95      

Phe Ile Asp Glu Tyr Glu Arg Ile Arg Lys Ile Glu Glu His Ile Gly 
            100                 105                 110         

Leu Gln 
        

<210>   811
<211>   1410
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   811
atggaaaatt tacaggttaa agccttaccg aaggagtttt tattaggaac tgctaccgct   60
gcttatcaag tagagggtgc aactagggta gatggcaaag gaataaatat gtgggatgtt   120
tatttgcaag aaaatagtcc gttcttacca gatccagcta gtgattttta ttatcgttac   180
gaagaggata tagctttggc ggcagaacat ggtttgcagg ctttgcgttt atctatttct   240
tgggttcgta tatttcctga tatagatggg gatgctaatg tattagctgt tcattattac   300
catagagttt ttcagtcttg cttaaaacat aatgtgattc cgtttgtttc tttacatcat   360
tttgattcgc ctcagaaaat gttagaaaca ggggattggt tgaacagaga gaatattgat   420

cgtttcatac gatatgctcg cttttgtttc caagaattta cagaagtcaa gcattggttt   480
acaatcaatg aactgatgtc tcttgctgca ggtcaatata taggaggtca gtttcctcca   540
aatcatcatt ttcaattatc tgaagcaatt caagcgaatc ataatatgtt gttggcgcat   600
gctcttgcag tcctcgaatt tcatcaatta gggattgagg gaaaggtagg ttgtattcat   660
gctttaaagc caggctatcc tattgatggg caaaaagaaa atattttggc agctaaacgg   720
tatgatgttt ataataataa atttctatta gatggaactt ttttgggcta ctacagtgag   780
gacacgcttt ttcacttgaa tcaaatattg gaagctaata attctagctt tattattgaa   840
gatggtgatt tagaaattat gaagagagct gcacctctta atacgatgtt tgggatgaat   900
tattatcgtt cagaatttat tcgtgaatac aaaggtgaaa atagacaaga atttaattca   960
acaggaataa aaggacagtc ttcttttaaa ttaaatgctc taggtgaatt tgtaaaaaaa   1020
cctggtattc cgacaacaga ttgggattgg aatatttatc ctcaagggtt atttgatatg   1080
ttgcttcgta tcaaagaaga atatcctcaa catccggtca tttatttaac tgaaaatggt   1140
acagccctta aagaagttaa gccagagggc gagaatgata ttattgatga cagtaagaga   1200
atccgttata ttgagcaaca tttacacaaa gttttagagg ctcgagatag aggagtcaat   1260
attcaaggct attttatatg gtctttgcaa gatcaatttt cttgggcgaa tggctacaat   1320
aagcgatatg gtcttttctt tgttgattat gaaacacaga agagatatat taagaaaagt   1380
gctctttggg taaaagggct aaaacggaat                                    1410

<210>   812
<211>   470
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   6-phospho-beta-galactosidase (lacG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902468 (0.E+01)

<400>   812
Met Glu Asn Leu Gln Val Lys Ala Leu Pro Lys Glu Phe Leu Leu Gly 
1               5                   10                  15      

Thr Ala Thr Ala Ala Tyr Gln Val Glu Gly Ala Thr Arg Val Asp Gly 
            20                  25                  30          

Lys Gly Ile Asn Met Trp Asp Val Tyr Leu Gln Glu Asn Ser Pro Phe 
        35                  40                  45              

Leu Pro Asp Pro Ala Ser Asp Phe Tyr Tyr Arg Tyr Glu Glu Asp Ile 
    50                  55                  60                  

Ala Leu Ala Ala Glu His Gly Leu Gln Ala Leu Arg Leu Ser Ile Ser 
65                  70                  75                  80  

Trp Val Arg Ile Phe Pro Asp Ile Asp Gly Asp Ala Asn Val Leu Ala 
                85                  90                  95      

Val His Tyr Tyr His Arg Val Phe Gln Ser Cys Leu Lys His Asn Val 
            100                 105                 110         

Ile Pro Phe Val Ser Leu His His Phe Asp Ser Pro Gln Lys Met Leu 
        115                 120                 125             

Glu Thr Gly Asp Trp Leu Asn Arg Glu Asn Ile Asp Arg Phe Ile Arg 
    130                 135                 140                 

Tyr Ala Arg Phe Cys Phe Gln Glu Phe Thr Glu Val Lys His Trp Phe 
145                 150                 155                 160 

Thr Ile Asn Glu Leu Met Ser Leu Ala Ala Gly Gln Tyr Ile Gly Gly 
                165                 170                 175     

Gln Phe Pro Pro Asn His His Phe Gln Leu Ser Glu Ala Ile Gln Ala 
            180                 185                 190         

Asn His Asn Met Leu Leu Ala His Ala Leu Ala Val Leu Glu Phe His 
        195                 200                 205             

Gln Leu Gly Ile Glu Gly Lys Val Gly Cys Ile His Ala Leu Lys Pro 
    210                 215                 220                 

Gly Tyr Pro Ile Asp Gly Gln Lys Glu Asn Ile Leu Ala Ala Lys Arg 
225                 230                 235                 240 

Tyr Asp Val Tyr Asn Asn Lys Phe Leu Leu Asp Gly Thr Phe Leu Gly 
                245                 250                 255     

Tyr Tyr Ser Glu Asp Thr Leu Phe His Leu Asn Gln Ile Leu Glu Ala 
            260                 265                 270         

Asn Asn Ser Ser Phe Ile Ile Glu Asp Gly Asp Leu Glu Ile Met Lys 
        275                 280                 285             

Arg Ala Ala Pro Leu Asn Thr Met Phe Gly Met Asn Tyr Tyr Arg Ser 
    290                 295                 300                 

Glu Phe Ile Arg Glu Tyr Lys Gly Glu Asn Arg Gln Glu Phe Asn Ser 
305                 310                 315                 320 

Thr Gly Ile Lys Gly Gln Ser Ser Phe Lys Leu Asn Ala Leu Gly Glu 
                325                 330                 335     

Phe Val Lys Lys Pro Gly Ile Pro Thr Thr Asp Trp Asp Trp Asn Ile 
            340                 345                 350         

Tyr Pro Gln Gly Leu Phe Asp Met Leu Leu Arg Ile Lys Glu Glu Tyr 
        355                 360                 365             

Pro Gln His Pro Val Ile Tyr Leu Thr Glu Asn Gly Thr Ala Leu Lys 
    370                 375                 380                 

Glu Val Lys Pro Glu Gly Glu Asn Asp Ile Ile Asp Asp Ser Lys Arg 
385                 390                 395                 400 

Ile Arg Tyr Ile Glu Gln His Leu His Lys Val Leu Glu Ala Arg Asp 
                405                 410                 415     

Arg Gly Val Asn Ile Gln Gly Tyr Phe Ile Trp Ser Leu Gln Asp Gln 
            420                 425                 430         

Phe Ser Trp Ala Asn Gly Tyr Asn Lys Arg Tyr Gly Leu Phe Phe Val 
        435                 440                 445             

Asp Tyr Glu Thr Gln Lys Arg Tyr Ile Lys Lys Ser Ala Leu Trp Val 
    450                 455                 460                 

Lys Gly Leu Lys Arg Asn 
465                 470 

<210>   813
<211>   1677
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   813
atggataagc tagtcgctgc cattgaaaag caacaaggga aatttgaaaa aatttctact   60
aataactata tgatggctat taaagatgga ttcattgcta ctatgccttt aattatgttt   120
tcaagctttt tgatgattat tattatgatt cctaaaaatt tcggagtaga gttaccgagt   180
ccagctattg tctggatgag aaaagtgtat atgttaacca tgggagtttt gggtattatt   240
gtttcaggga ctgttggaaa gtcattagtt ggaaatgtta acagaaaaat gcctcacgga   300
aaggtaataa atgatatttc tgcaatgttg gcagccatat gtagttatct ggtattaact   360
gtaacgcttg tagttgatga gaagacggga tctacaagtt tgtcgacaaa ctatttagga   420
tctcaaggat tgataacttc gtttgtcagt gcctttatta ctgtaaatgt ttaccgattc   480
tgtattaagc gagacattac tattcattta cctaaggaag ttcctggggc tatatcacaa   540
gcttttagag atattttccc tttttctttt gttttactta ttagtggttt gttagatatt   600
gtatctcggt ttagtttaga tgttcctttt gcccaagtat ttcaacaact attgactcct   660
atttttaagg gggcagaatc atatcctgct atgatgttga tttggtttat gtgtgctttg   720
ctttggtttg ttggaattca tggaccatct attgtcttac ctgctgttac agctttgcaa   780
ctgagcaata tggaagagaa tgctcaactt cttgcaaatg ggcagttccc ttatcattct   840
ttaacaccta atttcgggaa ttatatcgct gctattggag gaacgggggc tacctttgtt   900
gtaccattta ttttgatttt ctttatgcgg tctaaacaat taaaatcggt aggtaaagct   960
acaattactc ctgttttatt tgcggtaaat gaacctcttc tatttggtat gcctgttatt   1020
ttgaatccct atctttttgt cccttttttg atgactccac cagtgaatgt atttctagga   1080
aaggtcttta ttgatttctt tggaatgaat ggattttata tccagttacc ttggaccttt   1140
cctggtccct tgggattgtt aattggaacg aattttcaac ttatctcctt tgtattttta   1200
tctttgattt tagttgtcga catattgatt tatttgccat tctgtagagc gtatgataga   1260
cagttactgg tgaaagaaga tattgcaagc tcaaatgata ttattttaga ggaggataca   1320
agtgaaataa ttcctggtga gatagatgaa ataaaaagta aggagttgaa agtactggtt   1380
ctttgtgcag ggtctggaac aagtgcgcaa ttagccaatg caattaacga gggggctaac   1440
ttaacagagg ttagagtgat tgcgaattca ggagcgtacg gagctcatta tgatattatg   1500
ggtgtttatg atttaattat tctggcccca caagttcgga gttattatag agagatgaag   1560
gtggatgcag aaagattagg tattcagata gttgctacca gaggaatgga atatattcat   1620
ttaacaaaga gtccaagtaa agccttacaa tttgtattgg agcattacca agctgtg      1677

<210>   814
<211>   559
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, lactose-specific IIBC components (lacE)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902469 (0.E+01)

<400>   814
Met Asp Lys Leu Val Ala Ala Ile Glu Lys Gln Gln Gly Lys Phe Glu 
1               5                   10                  15      

Lys Ile Ser Thr Asn Asn Tyr Met Met Ala Ile Lys Asp Gly Phe Ile 
            20                  25                  30          

Ala Thr Met Pro Leu Ile Met Phe Ser Ser Phe Leu Met Ile Ile Ile 
        35                  40                  45              

Met Ile Pro Lys Asn Phe Gly Val Glu Leu Pro Ser Pro Ala Ile Val 
    50                  55                  60                  

Trp Met Arg Lys Val Tyr Met Leu Thr Met Gly Val Leu Gly Ile Ile 
65                  70                  75                  80  

Val Ser Gly Thr Val Gly Lys Ser Leu Val Gly Asn Val Asn Arg Lys 
                85                  90                  95      

Met Pro His Gly Lys Val Ile Asn Asp Ile Ser Ala Met Leu Ala Ala 
            100                 105                 110         

Ile Cys Ser Tyr Leu Val Leu Thr Val Thr Leu Val Val Asp Glu Lys 
        115                 120                 125             

Thr Gly Ser Thr Ser Leu Ser Thr Asn Tyr Leu Gly Ser Gln Gly Leu 
    130                 135                 140                 

Ile Thr Ser Phe Val Ser Ala Phe Ile Thr Val Asn Val Tyr Arg Phe 
145                 150                 155                 160 

Cys Ile Lys Arg Asp Ile Thr Ile His Leu Pro Lys Glu Val Pro Gly 
                165                 170                 175     

Ala Ile Ser Gln Ala Phe Arg Asp Ile Phe Pro Phe Ser Phe Val Leu 
            180                 185                 190         

Leu Ile Ser Gly Leu Leu Asp Ile Val Ser Arg Phe Ser Leu Asp Val 
        195                 200                 205             

Pro Phe Ala Gln Val Phe Gln Gln Leu Leu Thr Pro Ile Phe Lys Gly 
    210                 215                 220                 

Ala Glu Ser Tyr Pro Ala Met Met Leu Ile Trp Phe Met Cys Ala Leu 
225                 230                 235                 240 

Leu Trp Phe Val Gly Ile His Gly Pro Ser Ile Val Leu Pro Ala Val 
                245                 250                 255     

Thr Ala Leu Gln Leu Ser Asn Met Glu Glu Asn Ala Gln Leu Leu Ala 
            260                 265                 270         

Asn Gly Gln Phe Pro Tyr His Ser Leu Thr Pro Asn Phe Gly Asn Tyr 
        275                 280                 285             

Ile Ala Ala Ile Gly Gly Thr Gly Ala Thr Phe Val Val Pro Phe Ile 
    290                 295                 300                 

Leu Ile Phe Phe Met Arg Ser Lys Gln Leu Lys Ser Val Gly Lys Ala 
305                 310                 315                 320 

Thr Ile Thr Pro Val Leu Phe Ala Val Asn Glu Pro Leu Leu Phe Gly 
                325                 330                 335     

Met Pro Val Ile Leu Asn Pro Tyr Leu Phe Val Pro Phe Leu Met Thr 
            340                 345                 350         

Pro Pro Val Asn Val Phe Leu Gly Lys Val Phe Ile Asp Phe Phe Gly 
        355                 360                 365             

Met Asn Gly Phe Tyr Ile Gln Leu Pro Trp Thr Phe Pro Gly Pro Leu 
    370                 375                 380                 

Gly Leu Leu Ile Gly Thr Asn Phe Gln Leu Ile Ser Phe Val Phe Leu 
385                 390                 395                 400 

Ser Leu Ile Leu Val Val Asp Ile Leu Ile Tyr Leu Pro Phe Cys Arg 
                405                 410                 415     

Ala Tyr Asp Arg Gln Leu Leu Val Lys Glu Asp Ile Ala Ser Ser Asn 
            420                 425                 430         

Asp Ile Ile Leu Glu Glu Asp Thr Ser Glu Ile Ile Pro Gly Glu Ile 
        435                 440                 445             

Asp Glu Ile Lys Ser Lys Glu Leu Lys Val Leu Val Leu Cys Ala Gly 
    450                 455                 460                 

Ser Gly Thr Ser Ala Gln Leu Ala Asn Ala Ile Asn Glu Gly Ala Asn 
465                 470                 475                 480 

Leu Thr Glu Val Arg Val Ile Ala Asn Ser Gly Ala Tyr Gly Ala His 
                485                 490                 495     

Tyr Asp Ile Met Gly Val Tyr Asp Leu Ile Ile Leu Ala Pro Gln Val 
            500                 505                 510         

Arg Ser Tyr Tyr Arg Glu Met Lys Val Asp Ala Glu Arg Leu Gly Ile 
        515                 520                 525             

Gln Ile Val Ala Thr Arg Gly Met Glu Tyr Ile His Leu Thr Lys Ser 
    530                 535                 540                 

Pro Ser Lys Ala Leu Gln Phe Val Leu Glu His Tyr Gln Ala Val 
545                 550                 555                 

<210>   815
<211>   1437
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   815
atgaataaaa gtatgattcg ttacctcctt tcaaaattac ttttgattga agctgttctt   60
cttttggttc ctgttgcgat tgctgtctat taccgtgaat cgagccaagt ctttacagcc   120
ctcttttcga ccatagggat tctcgtattg ttaggcggtt cagggagttt acagaagcca   180
aaaaatcaac ggatttatgc caaggaggga gtcttgatcg ttgccctctg ttggatcctt   240
tggtctttct ttggtggtct cccctttgtc ttttctgggc aaatccccag ccttattgat   300
gccttttttg aaattagttc tggatttaca actactggag caagtatttt gaacgacgtt   360
tcggttctca gccgttccct cctcttctgg cgaagtttta cccacttgat tggagggatg   420
ggagtgcttg tttttgcact tgctattatg gacaatgcca aaaatagcca cctagaggtg   480
atgaaggctg aggttccagg tcctgttttt ggcaaggttg tatccaaact aaaaaacact   540
gcccagattc tctatctcct ttatctagct ctcttctccc tctttgtcat catctattat   600
ctagccggta tgcctctcta cgatagtttt gttattgcta tggggacagc gggaactgga   660
ggctttaccg tctataacga cggaattgcc cactatggca gctcactgat tacctatctg   720
gtcagtatcg gagttctggt ttttggagta aatttcaacc tctactacta cctcatgctc   780
cgtcgcatca aggccttctt tggagatgaa gagcttaggg cttacttggt cattgtactg   840
gtttctacag gcttgattag cctcaacacc ctctacctct acccagggtt ttcaaagagc   900
tttgaaatga ccttcttcca ggtttccaac atcattacaa caactggttt tggatatgga   960
gatattacca actggcccct cttctcccag tttatcctcc ttttcctcat ggcaatcggt   1020
ggctctgctg gatcaactgc aggtggactc aagattattc gaggcctcat cctttcaaaa   1080
attgccaaaa accaaatttt gtcaatccta tcgccccacc gtgttttgac cctccatgtt   1140
aataaaacgg tgattgacaa agatacccag cataagattc tcaagtactt tgtcatctat   1200
gctatgattt tgctagcgct tatctttatt gtcagcctag atagcaatga ttttctggtc   1260
gtgaccagcg ctgtctttag ctgtttcaat aatatcgggc ctattctagg aaccacttct   1320
agtttctcaa tctttagtcc catctcaaaa attctcctat cctttgcaat gattgcaggg   1380
cgcttggaga tttacccaat cctccttctc tttatgaaga gaacttggtc taagaga      1437

<210>   816
<211>   479
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   potassium uptake protein, Trk family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902470 (0.E+01)

<400>   816
Met Asn Lys Ser Met Ile Arg Tyr Leu Leu Ser Lys Leu Leu Leu Ile 
1               5                   10                  15      

Glu Ala Val Leu Leu Leu Val Pro Val Ala Ile Ala Val Tyr Tyr Arg 
            20                  25                  30          

Glu Ser Ser Gln Val Phe Thr Ala Leu Phe Ser Thr Ile Gly Ile Leu 
        35                  40                  45              

Val Leu Leu Gly Gly Ser Gly Ser Leu Gln Lys Pro Lys Asn Gln Arg 
    50                  55                  60                  


Ile Tyr Ala Lys Glu Gly Val Leu Ile Val Ala Leu Cys Trp Ile Leu 
65                  70                  75                  80  

Trp Ser Phe Phe Gly Gly Leu Pro Phe Val Phe Ser Gly Gln Ile Pro 
                85                  90                  95      

Ser Leu Ile Asp Ala Phe Phe Glu Ile Ser Ser Gly Phe Thr Thr Thr 
            100                 105                 110         

Gly Ala Ser Ile Leu Asn Asp Val Ser Val Leu Ser Arg Ser Leu Leu 
        115                 120                 125             

Phe Trp Arg Ser Phe Thr His Leu Ile Gly Gly Met Gly Val Leu Val 
    130                 135                 140                 

Phe Ala Leu Ala Ile Met Asp Asn Ala Lys Asn Ser His Leu Glu Val 
145                 150                 155                 160 

Met Lys Ala Glu Val Pro Gly Pro Val Phe Gly Lys Val Val Ser Lys 
                165                 170                 175     

Leu Lys Asn Thr Ala Gln Ile Leu Tyr Leu Leu Tyr Leu Ala Leu Phe 
            180                 185                 190         

Ser Leu Phe Val Ile Ile Tyr Tyr Leu Ala Gly Met Pro Leu Tyr Asp 
        195                 200                 205             

Ser Phe Val Ile Ala Met Gly Thr Ala Gly Thr Gly Gly Phe Thr Val 
    210                 215                 220                 

Tyr Asn Asp Gly Ile Ala His Tyr Gly Ser Ser Leu Ile Thr Tyr Leu 
225                 230                 235                 240 

Val Ser Ile Gly Val Leu Val Phe Gly Val Asn Phe Asn Leu Tyr Tyr 
                245                 250                 255     

Tyr Leu Met Leu Arg Arg Ile Lys Ala Phe Phe Gly Asp Glu Glu Leu 
            260                 265                 270         

Arg Ala Tyr Leu Val Ile Val Leu Val Ser Thr Gly Leu Ile Ser Leu 
        275                 280                 285             

Asn Thr Leu Tyr Leu Tyr Pro Gly Phe Ser Lys Ser Phe Glu Met Thr 
    290                 295                 300                 

Phe Phe Gln Val Ser Asn Ile Ile Thr Thr Thr Gly Phe Gly Tyr Gly 
305                 310                 315                 320 

Asp Ile Thr Asn Trp Pro Leu Phe Ser Gln Phe Ile Leu Leu Phe Leu 
                325                 330                 335     

Met Ala Ile Gly Gly Ser Ala Gly Ser Thr Ala Gly Gly Leu Lys Ile 
            340                 345                 350         

Ile Arg Gly Leu Ile Leu Ser Lys Ile Ala Lys Asn Gln Ile Leu Ser 
        355                 360                 365             

Ile Leu Ser Pro His Arg Val Leu Thr Leu His Val Asn Lys Thr Val 
    370                 375                 380                 

Ile Asp Lys Asp Thr Gln His Lys Ile Leu Lys Tyr Phe Val Ile Tyr 
385                 390                 395                 400 

Ala Met Ile Leu Leu Ala Leu Ile Phe Ile Val Ser Leu Asp Ser Asn 
                405                 410                 415     

Asp Phe Leu Val Val Thr Ser Ala Val Phe Ser Cys Phe Asn Asn Ile 
            420                 425                 430         

Gly Pro Ile Leu Gly Thr Thr Ser Ser Phe Ser Ile Phe Ser Pro Ile 
        435                 440                 445             

Ser Lys Ile Leu Leu Ser Phe Ala Met Ile Ala Gly Arg Leu Glu Ile 
    450                 455                 460                 

Tyr Pro Ile Leu Leu Leu Phe Met Lys Arg Thr Trp Ser Lys Arg 
465                 470                 475                 

<210>   817
<211>   1347
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   817
atgaaaatta tccttgtcgg agggggaaaa gttggttttg ccctctgtcg ctccttggtt   60
gcagaaaagc atgatgtttt gctgattgag caagacgaag ctgttctcaa tcatattgtc   120
agtcgctttg atatcattgg tatccttggt aacggggccg attttgccat tcttgagcaa   180
gccagcgtcc aagattgtga tatctttatc gccctgactg agcacgatga agtcaacatg   240
attgcagcag ttctagccaa gaaaatggga gctaaagaaa ctatcgttcg ggtgcggaac   300
cctgaatatt ctaactctta tttcaaggaa aagaatattc tcggtttttc tcttatcgtt   360
aatcctgagc tcttggctgc ccgcgctatc gcgaatatca ttgacttccc caacgccctg   420
tctgtcgaac gctttgctgg tggacgcgtt agcctcatgg aatttgtcgt caagtccacc   480
agcggtcttt gccaaatgcc catttctgat tttcgtaaaa aatttggtaa tgtcattgtc   540
tgtgcgatag agagggatca tcaaattatc attccaagcg gtgacatgac tgtacaggat   600
aaagatagaa tctttgtcac tggtaaccgt gtcgatatga tactcttcca taattatttt   660
aaatcacgcg ccgtgaagag ccttctcatc gttggggcag gtagaattgc ctattatcta   720
cttggtattc tcaaagatag tcgtatcgat acaaaagtca ttgaaatcaa tcctgaaatc   780
gccagcttct ttagcgagaa attcccaaat ctctacatcg ttcaaggaga tggaaccgca   840
aaagatatcc tgctggaaga aagtgctcaa cactatgatg ccgttgcgac tctaacagga   900
gtcgatgagg aaaatctgat tacatctatg ttccttgaca gggtaggtgt acagaaaaat   960
attactaagg tcaatcgtac cagtctcctc gagattatca atgcgcctga tttttcaagt   1020
atcatcacac ctaaaagcat cgctgtagat acgattatgc actttattcg tggtcgagtt   1080
aatgcccagt attcagacct tcaagctatg caccatctag ccaatggcca aatcgaaacc   1140
ctgcaattcc atatcaagga agccaataaa atgactgcca aacctctttc tcaactgaaa   1200
ttgaaaaaag gggttcttat tgcagccatt attcgaaagg gcaagactat tttcccaact   1260
ggggaggata tgttggaagt tggagacaag ctcctagtaa caaccttgtt gccaaacatc   1320
accaagattt atgacttgat cgcgagg                                       1347

<210>   818
<211>   449
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   potassium uptake protein, Trk family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902471 (0.E+01)

<400>   818
Met Lys Ile Ile Leu Val Gly Gly Gly Lys Val Gly Phe Ala Leu Cys 
1               5                   10                  15      

Arg Ser Leu Val Ala Glu Lys His Asp Val Leu Leu Ile Glu Gln Asp 
            20                  25                  30          

Glu Ala Val Leu Asn His Ile Val Ser Arg Phe Asp Ile Ile Gly Ile 
        35                  40                  45              

Leu Gly Asn Gly Ala Asp Phe Ala Ile Leu Glu Gln Ala Ser Val Gln 
    50                  55                  60                  

Asp Cys Asp Ile Phe Ile Ala Leu Thr Glu His Asp Glu Val Asn Met 
65                  70                  75                  80  

Ile Ala Ala Val Leu Ala Lys Lys Met Gly Ala Lys Glu Thr Ile Val 
                85                  90                  95      

Arg Val Arg Asn Pro Glu Tyr Ser Asn Ser Tyr Phe Lys Glu Lys Asn 
            100                 105                 110         

Ile Leu Gly Phe Ser Leu Ile Val Asn Pro Glu Leu Leu Ala Ala Arg 
        115                 120                 125             

Ala Ile Ala Asn Ile Ile Asp Phe Pro Asn Ala Leu Ser Val Glu Arg 
    130                 135                 140                 

Phe Ala Gly Gly Arg Val Ser Leu Met Glu Phe Val Val Lys Ser Thr 
145                 150                 155                 160 

Ser Gly Leu Cys Gln Met Pro Ile Ser Asp Phe Arg Lys Lys Phe Gly 
                165                 170                 175     

Asn Val Ile Val Cys Ala Ile Glu Arg Asp His Gln Ile Ile Ile Pro 
            180                 185                 190         

Ser Gly Asp Met Thr Val Gln Asp Lys Asp Arg Ile Phe Val Thr Gly 
        195                 200                 205             

Asn Arg Val Asp Met Ile Leu Phe His Asn Tyr Phe Lys Ser Arg Ala 
    210                 215                 220                 

Val Lys Ser Leu Leu Ile Val Gly Ala Gly Arg Ile Ala Tyr Tyr Leu 
225                 230                 235                 240 

Leu Gly Ile Leu Lys Asp Ser Arg Ile Asp Thr Lys Val Ile Glu Ile 
                245                 250                 255     

Asn Pro Glu Ile Ala Ser Phe Phe Ser Glu Lys Phe Pro Asn Leu Tyr 
            260                 265                 270         

Ile Val Gln Gly Asp Gly Thr Ala Lys Asp Ile Leu Leu Glu Glu Ser 
        275                 280                 285             

Ala Gln His Tyr Asp Ala Val Ala Thr Leu Thr Gly Val Asp Glu Glu 
    290                 295                 300                 

Asn Leu Ile Thr Ser Met Phe Leu Asp Arg Val Gly Val Gln Lys Asn 
305                 310                 315                 320 

Ile Thr Lys Val Asn Arg Thr Ser Leu Leu Glu Ile Ile Asn Ala Pro 
                325                 330                 335     

Asp Phe Ser Ser Ile Ile Thr Pro Lys Ser Ile Ala Val Asp Thr Ile 
            340                 345                 350         

Met His Phe Ile Arg Gly Arg Val Asn Ala Gln Tyr Ser Asp Leu Gln 
        355                 360                 365             

Ala Met His His Leu Ala Asn Gly Gln Ile Glu Thr Leu Gln Phe His 
    370                 375                 380                 

Ile Lys Glu Ala Asn Lys Met Thr Ala Lys Pro Leu Ser Gln Leu Lys 
385                 390                 395                 400 

Leu Lys Lys Gly Val Leu Ile Ala Ala Ile Ile Arg Lys Gly Lys Thr 
                405                 410                 415     

Ile Phe Pro Thr Gly Glu Asp Met Leu Glu Val Gly Asp Lys Leu Leu 
            420                 425                 430         

Val Thr Thr Leu Leu Pro Asn Ile Thr Lys Ile Tyr Asp Leu Ile Ala 
        435                 440                 445             

Arg 
    

<210>   819
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   819
atgataaagg atatacaagg agataaaatg aataataatt tactggtatt acaatcagac   60
tttggtctgg ttgatggtgc ggtatcggct atgattggag tggctttaga agagtctcca   120
accttaaaaa tacatcactt gacgcacgat atcacgcctt ataatatttt tgaggggagc   180
tatcgtctct ttcagacggt ggattactgg cctgagggaa cgacgtttgt atcggttgtc   240
gatccaggtg tcggttcgaa acgtaagagt gtagttgcca agactgcaaa aaatcaatac   300
attgtcacgc cagataatgg gacgctttcc tttatcaaga aacacgttgg cattgtagcc   360
attcgtgaga tttctgaggt ggccaatagg cgtcaaaaca cagagcattc ttataccttc   420
cacggtcgtg atgtctatgc ctatactggt gctaaactgg ccagtggtca cattactttt   480
gaggaagtag ggccagagct cagtgtggaa cagattgtag agcttccagt cgtagcgacc   540
atcatagaag atcatctggt gaagggagcc attgatattc tggatgtgcg tttcggttcg   600
ctttggacct ctatcacacg ggaagaattt tacaagctgg aaccagaatt tggtgatcgt   660
tttgaagtga ccatctatca tgctgatatg ctggtctatc aaaatcaggt tgtctatggc   720
aaatcatttg cagatgtgag aattgggcaa cccatccttt acatcaactc tctctatcgt   780
ttaggtttgg ctatcaacca aggttccttt gccaaggcct ataatgtagg tgtcggttca   840
tcttggacca ttgaaataaa gaaaatagaa gga                                873

<210>   820
<211>   291
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902472 (e-167)

<400>   820
Met Ile Lys Asp Ile Gln Gly Asp Lys Met Asn Asn Asn Leu Leu Val 
1               5                   10                  15      

Leu Gln Ser Asp Phe Gly Leu Val Asp Gly Ala Val Ser Ala Met Ile 
            20                  25                  30          

Gly Val Ala Leu Glu Glu Ser Pro Thr Leu Lys Ile His His Leu Thr 
        35                  40                  45              

His Asp Ile Thr Pro Tyr Asn Ile Phe Glu Gly Ser Tyr Arg Leu Phe 
    50                  55                  60                  

Gln Thr Val Asp Tyr Trp Pro Glu Gly Thr Thr Phe Val Ser Val Val 
65                  70                  75                  80  

Asp Pro Gly Val Gly Ser Lys Arg Lys Ser Val Val Ala Lys Thr Ala 
                85                  90                  95      

Lys Asn Gln Tyr Ile Val Thr Pro Asp Asn Gly Thr Leu Ser Phe Ile 
            100                 105                 110         

Lys Lys His Val Gly Ile Val Ala Ile Arg Glu Ile Ser Glu Val Ala 
        115                 120                 125             

Asn Arg Arg Gln Asn Thr Glu His Ser Tyr Thr Phe His Gly Arg Asp 
    130                 135                 140                 

Val Tyr Ala Tyr Thr Gly Ala Lys Leu Ala Ser Gly His Ile Thr Phe 
145                 150                 155                 160 

Glu Glu Val Gly Pro Glu Leu Ser Val Glu Gln Ile Val Glu Leu Pro 
                165                 170                 175     

Val Val Ala Thr Ile Ile Glu Asp His Leu Val Lys Gly Ala Ile Asp 
            180                 185                 190         

Ile Leu Asp Val Arg Phe Gly Ser Leu Trp Thr Ser Ile Thr Arg Glu 
        195                 200                 205             

Glu Phe Tyr Lys Leu Glu Pro Glu Phe Gly Asp Arg Phe Glu Val Thr 
    210                 215                 220                 

Ile Tyr His Ala Asp Met Leu Val Tyr Gln Asn Gln Val Val Tyr Gly 
225                 230                 235                 240 

Lys Ser Phe Ala Asp Val Arg Ile Gly Gln Pro Ile Leu Tyr Ile Asn 
                245                 250                 255     

Ser Leu Tyr Arg Leu Gly Leu Ala Ile Asn Gln Gly Ser Phe Ala Lys 
            260                 265                 270         

Ala Tyr Asn Val Gly Val Gly Ser Ser Trp Thr Ile Glu Ile Lys Lys 
        275                 280                 285             

Ile Glu Gly 
    290     

<210>   821
<211>   546
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   821
atggaaatca aatttacaat taaacaagtt gttgctgtcg gaattggcgc tgccctcttt   60
gtcgtcatcg ggatgatcaa cattccaacc cctgttccaa atacaagcat ccagcttcag   120
tatgcggtac aagcgctact ttctattatt tttggaccga ttatcggttt gcttgtcggg   180
ttgattggtc atgcaatcaa ggactctctt gttggttatg gtctatggtg gacttggatt   240
atcgctagcg gactctttgg tttagttgtg ggacttttta gaaagtacgt tcgcgtgatc   300
aatggtgttt ttgactggaa agatattctt atttttaatc tcattcaact acttgcaaat   360
gcccttgttt ggggtgtctt ggcaccactt ggagatgttg tgatttatca agaagcggca   420
gaaaaagtat ttgcacaagg gattgttgcg ggaattgcca atggtgtatc tgtagctatt   480
gcaggaactc ttctcttact tgcctatgca ggaacccaaa ctcgtgcagg aagtttgaaa   540
aaggac                                                              546

<210>   822
<211>   182
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902473 (2.E-99)

<400>   822
Met Glu Ile Lys Phe Thr Ile Lys Gln Val Val Ala Val Gly Ile Gly 
1               5                   10                  15      

Ala Ala Leu Phe Val Val Ile Gly Met Ile Asn Ile Pro Thr Pro Val 

            20                  25                  30          

Pro Asn Thr Ser Ile Gln Leu Gln Tyr Ala Val Gln Ala Leu Leu Ser 
        35                  40                  45              

Ile Ile Phe Gly Pro Ile Ile Gly Leu Leu Val Gly Leu Ile Gly His 
    50                  55                  60                  

Ala Ile Lys Asp Ser Leu Val Gly Tyr Gly Leu Trp Trp Thr Trp Ile 
65                  70                  75                  80  

Ile Ala Ser Gly Leu Phe Gly Leu Val Val Gly Leu Phe Arg Lys Tyr 
                85                  90                  95      

Val Arg Val Ile Asn Gly Val Phe Asp Trp Lys Asp Ile Leu Ile Phe 
            100                 105                 110         

Asn Leu Ile Gln Leu Leu Ala Asn Ala Leu Val Trp Gly Val Leu Ala 
        115                 120                 125             

Pro Leu Gly Asp Val Val Ile Tyr Gln Glu Ala Ala Glu Lys Val Phe 
    130                 135                 140                 

Ala Gln Gly Ile Val Ala Gly Ile Ala Asn Gly Val Ser Val Ala Ile 
145                 150                 155                 160 

Ala Gly Thr Leu Leu Leu Leu Ala Tyr Ala Gly Thr Gln Thr Arg Ala 
                165                 170                 175     

Gly Ser Leu Lys Lys Asp 
            180         

<210>   823
<211>   255
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   823
atgaaaatca aagagcaaac taggaagcta gccgcaggtt gctcaaaaca gtgttttgag   60
attgtggata gaactgacga agtcgactca aaacatggtt ttgaggttgt agatgaaact   120
gacgaagtca gtaaccatac ctacggcaag gcgaagctga cgtggtttga agagattttc   180
gaagagtata aaatgatggg gaaggctggg caactagtct ttttcgatgt ttatagatta   240
gttaggcaag taagc                                                    255

<210>   824
<211>   85
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   824
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

Gln Cys Phe Glu Ile Val Asp Arg Thr Asp Glu Val Asp Ser Lys His 
            20                  25                  30          

Gly Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Asn His Thr Tyr 
        35                  40                  45              

Gly Lys Ala Lys Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr Lys 
    50                  55                  60                  

Met Met Gly Lys Ala Gly Gln Leu Val Phe Phe Asp Val Tyr Arg Leu 
65                  70                  75                  80  

Val Arg Gln Val Ser 
                85  

<210>   825
<211>   1680
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   825
atgaaagaag ctataattga gtggaaggat ttctctttcc ggtatgaaac acaacaagaa   60
ccgaccttgc aagggataga cttgaccatt tacaagggag agaaagtctt aattgttgga   120
ccatctgggt caggtaaatc taccttgggt cagtgtttga atgggattat tcccaatatt   180
tacaagggtc agacatatgg agaatttttg ataaagggtc aagtagcctt tgatatgagc   240
atctatgata agtctcatct ggttagcaca gttttgcagg atacagatgg gcagtttatt   300
ggcttgtctg tggcagaaga tttggcgttt gctctggaaa atgatgtgac agccctagat   360
gagatgaaag gtcgtgttta taaatgggct gaaaagctgg accttcttcc tttactggat   420
cagcgtcctc aggatttgtc aggtggacaa aagcagcgag tcagtctggc tggtgtcttg   480
attgatgaaa gtccgattct cttgtttgat gagccactcg ccaatctaga tcccaagtca   540
ggtcaggata ttatcgaatt gattgaccag attcataagg aagaggggac gacgactctt   600
attatcgagc accgtttgga ggacgttctg catcgccctg tggatcggat tgtcttgata   660
aacgatggtc gtatcctttt taatgggagc cctgaccagt tgcttgcgac tgatttattg   720
actcaaaatg gaattcgaga acccctttat ctaacgactc tccgtcaatt aggtgtggac   780
ttagtcaagg aagaacaatt agcgaatctg gataacttgt ctatctcaaa aggtcaggtt   840
cagttgcaga atgaactggc aaaagaaacc ccagcattgc agtcactctt tagactagag   900
gaagtatctt tttcttatga tgatagaccg attttaaaat ccctacattt agatattaaa   960
aagggtgaaa agattgctat tgtcggaaaa aatggagcag ggaaatcaac tctagccaag   1020
gctataagta gctttattca gacggaagga cgctatcttt gggaaaaaca ggatataaaa   1080
ggcgattctg ttgcagagcg ggcggaacga gtaggatatg tgctacaaaa tcctaatcaa   1140
atgatttcaa ccaatatgat ttttgatgag gtggctctag ggctccgttt gcgaggtgtg   1200
gatgagaagg aaattgaaac gagagtatat gaaaccttga aaatctgtgg actttatgaa   1260
ttccgtaatt ggcctatttc tgccctgtca tttggtcaga aaaaacgtgt caccattgct   1320
tcaattttgg tcttaggagc tgaaattatt ctcctagatg aaccgactgc aggtcaagat   1380
cagaagaact atactgagat tatggaattt ctcgaagagt tacatcaaaa agggcatacc   1440
attgtcatga ttacccatga tatgcaattg atgctggatt attcagaccg ggtccttgtc   1500
atggtggatg gagaattgat tgccgatact gttccagcca gtctgttgag cgatcctgag   1560
ctgttagtaa aagccaatct aaaagaaacc tccatcttta acttggctaa gaaactagat   1620
gtggatccac tggatttaac ggcattttac aaagaaagga gagagggatg caagctaaat   1680

<210>   826
<211>   560
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902474 (0.E+01)

<400>   826
Met Lys Glu Ala Ile Ile Glu Trp Lys Asp Phe Ser Phe Arg Tyr Glu 
1               5                   10                  15      

Thr Gln Gln Glu Pro Thr Leu Gln Gly Ile Asp Leu Thr Ile Tyr Lys 
            20                  25                  30          

Gly Glu Lys Val Leu Ile Val Gly Pro Ser Gly Ser Gly Lys Ser Thr 
        35                  40                  45              

Leu Gly Gln Cys Leu Asn Gly Ile Ile Pro Asn Ile Tyr Lys Gly Gln 
    50                  55                  60                  

Thr Tyr Gly Glu Phe Leu Ile Lys Gly Gln Val Ala Phe Asp Met Ser 
65                  70                  75                  80  

Ile Tyr Asp Lys Ser His Leu Val Ser Thr Val Leu Gln Asp Thr Asp 
                85                  90                  95      

Gly Gln Phe Ile Gly Leu Ser Val Ala Glu Asp Leu Ala Phe Ala Leu 
            100                 105                 110         

Glu Asn Asp Val Thr Ala Leu Asp Glu Met Lys Gly Arg Val Tyr Lys 
        115                 120                 125             

Trp Ala Glu Lys Leu Asp Leu Leu Pro Leu Leu Asp Gln Arg Pro Gln 
    130                 135                 140                 

Asp Leu Ser Gly Gly Gln Lys Gln Arg Val Ser Leu Ala Gly Val Leu 
145                 150                 155                 160 

Ile Asp Glu Ser Pro Ile Leu Leu Phe Asp Glu Pro Leu Ala Asn Leu 
                165                 170                 175     

Asp Pro Lys Ser Gly Gln Asp Ile Ile Glu Leu Ile Asp Gln Ile His 
            180                 185                 190         

Lys Glu Glu Gly Thr Thr Thr Leu Ile Ile Glu His Arg Leu Glu Asp 
        195                 200                 205             

Val Leu His Arg Pro Val Asp Arg Ile Val Leu Ile Asn Asp Gly Arg 
    210                 215                 220                 

Ile Leu Phe Asn Gly Ser Pro Asp Gln Leu Leu Ala Thr Asp Leu Leu 
225                 230                 235                 240 


Thr Gln Asn Gly Ile Arg Glu Pro Leu Tyr Leu Thr Thr Leu Arg Gln 
                245                 250                 255     

Leu Gly Val Asp Leu Val Lys Glu Glu Gln Leu Ala Asn Leu Asp Asn 
            260                 265                 270         

Leu Ser Ile Ser Lys Gly Gln Val Gln Leu Gln Asn Glu Leu Ala Lys 
        275                 280                 285             

Glu Thr Pro Ala Leu Gln Ser Leu Phe Arg Leu Glu Glu Val Ser Phe 
    290                 295                 300                 

Ser Tyr Asp Asp Arg Pro Ile Leu Lys Ser Leu His Leu Asp Ile Lys 
305                 310                 315                 320 

Lys Gly Glu Lys Ile Ala Ile Val Gly Lys Asn Gly Ala Gly Lys Ser 
                325                 330                 335     

Thr Leu Ala Lys Ala Ile Ser Ser Phe Ile Gln Thr Glu Gly Arg Tyr 
            340                 345                 350         

Leu Trp Glu Lys Gln Asp Ile Lys Gly Asp Ser Val Ala Glu Arg Ala 
        355                 360                 365             

Glu Arg Val Gly Tyr Val Leu Gln Asn Pro Asn Gln Met Ile Ser Thr 
    370                 375                 380                 

Asn Met Ile Phe Asp Glu Val Ala Leu Gly Leu Arg Leu Arg Gly Val 
385                 390                 395                 400 

Asp Glu Lys Glu Ile Glu Thr Arg Val Tyr Glu Thr Leu Lys Ile Cys 
                405                 410                 415     

Gly Leu Tyr Glu Phe Arg Asn Trp Pro Ile Ser Ala Leu Ser Phe Gly 
            420                 425                 430         

Gln Lys Lys Arg Val Thr Ile Ala Ser Ile Leu Val Leu Gly Ala Glu 
        435                 440                 445             

Ile Ile Leu Leu Asp Glu Pro Thr Ala Gly Gln Asp Gln Lys Asn Tyr 
    450                 455                 460                 

Thr Glu Ile Met Glu Phe Leu Glu Glu Leu His Gln Lys Gly His Thr 
465                 470                 475                 480 

Ile Val Met Ile Thr His Asp Met Gln Leu Met Leu Asp Tyr Ser Asp 
                485                 490                 495     

Arg Val Leu Val Met Val Asp Gly Glu Leu Ile Ala Asp Thr Val Pro 
            500                 505                 510         

Ala Ser Leu Leu Ser Asp Pro Glu Leu Leu Val Lys Ala Asn Leu Lys 
        515                 520                 525             

Glu Thr Ser Ile Phe Asn Leu Ala Lys Lys Leu Asp Val Asp Pro Leu 
    530                 535                 540                 

Asp Leu Thr Ala Phe Tyr Lys Glu Arg Arg Glu Gly Cys Lys Leu Asn 
545                 550                 555                 560 


<210>   827
<211>   723
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   827
atgcaagcta aattaatcgg ttaccagcat agagatactg tgattcatcg cttgtcagga   60
gctgggaaac ttctcttttt cattctggta tcattggcgg ccatgattag ctatgatacc   120
agaatgctct tgctgattgc catcttttca gtctttctcc tctatttatc agaaattcgc   180
tttaaagatg tttcctttgt agccgttttt gcgacgatat ttgccgtttt aaacgttttg   240
atggtctatc tcttttctcc cgagtatggg gttggacttt atggagagag aagtgtgatt   300
tggcagggaa tcggtgtcta cactctaacc agccaggagc tcttttatct gctaaatttg   360
gccattaagt atctttgcac cattcctctg gctattatct ttttgatgac aacccatcct   420
agtcagtttg cttccagttt aaatcaaatt ggtgtgccct ataagattgc ttattctgtc   480
agcctgacct tgcgctatat tccagatttg caggaagaat tctttactat caagatgtct   540
caggaggcgc gtgggatgga attatccaag aaagcttctc ttatgcaacg aatcaaaggc   600
aatctgctca ttattacgcc cttgattttt agctcgctag aacgcattga taccattgcg   660
actgccatgg agttcgccgc tttgggaaag agaaaaaacg cacatggtat agttatcagg   720
cct                                                                 723

<210>   828
<211>   241
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein with frameshift (ABC transporter)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902475 (e-151)

<400>   828
Met Gln Ala Lys Leu Ile Gly Tyr Gln His Arg Asp Thr Val Ile His 
1               5                   10                  15      

Arg Leu Ser Gly Ala Gly Lys Leu Leu Phe Phe Ile Leu Val Ser Leu 
            20                  25                  30          

Ala Ala Met Ile Ser Tyr Asp Thr Arg Met Leu Leu Leu Ile Ala Ile 
        35                  40                  45              

Phe Ser Val Phe Leu Leu Tyr Leu Ser Glu Ile Arg Phe Lys Asp Val 
    50                  55                  60                  

Ser Phe Val Ala Val Phe Ala Thr Ile Phe Ala Val Leu Asn Val Leu 
65                  70                  75                  80  

Met Val Tyr Leu Phe Ser Pro Glu Tyr Gly Val Gly Leu Tyr Gly Glu 
                85                  90                  95      

Arg Ser Val Ile Trp Gln Gly Ile Gly Val Tyr Thr Leu Thr Ser Gln 
            100                 105                 110         

Glu Leu Phe Tyr Leu Leu Asn Leu Ala Ile Lys Tyr Leu Cys Thr Ile 
        115                 120                 125             

Pro Leu Ala Ile Ile Phe Leu Met Thr Thr His Pro Ser Gln Phe Ala 
    130                 135                 140                 

Ser Ser Leu Asn Gln Ile Gly Val Pro Tyr Lys Ile Ala Tyr Ser Val 
145                 150                 155                 160 

Ser Leu Thr Leu Arg Tyr Ile Pro Asp Leu Gln Glu Glu Phe Phe Thr 
                165                 170                 175     

Ile Lys Met Ser Gln Glu Ala Arg Gly Met Glu Leu Ser Lys Lys Ala 
            180                 185                 190         

Ser Leu Met Gln Arg Ile Lys Gly Asn Leu Leu Ile Ile Thr Pro Leu 
        195                 200                 205             

Ile Phe Ser Ser Leu Glu Arg Ile Asp Thr Ile Ala Thr Ala Met Glu 
    210                 215                 220                 

Phe Ala Ala Leu Gly Lys Arg Lys Asn Ala His Gly Ile Val Ile Arg 
225                 230                 235                 240 

Pro 
    

<210>   829
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   829
ttgaaaaaag gagactatat taccttgctc ttggcaacct tgtttttagt agttagttta   60
ctacttatct tgcagaatca gggacgattt tacaaccctt ggaaa                   105

<210>   830
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   830
Met Lys Lys Gly Asp Tyr Ile Thr Leu Leu Leu Ala Thr Leu Phe Leu 
1               5                   10                  15      

Val Val Ser Leu Leu Leu Ile Leu Gln Asn Gln Gly Arg Phe Tyr Asn 
            20                  25                  30          

Pro Trp Lys 
        35  

<210>   831
<211>   501
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   831
atgacaaatc acattgtatt atttgaacct caaattccac aaaatacggg caatatcgcg   60
cgtacttgcg ctgcgaccaa ttctcccctc cacatcatca agcctatggg ctttcctatt   120
gatgaccgca agatgaagcg ggctggattg gattactggg ataagctaga gatttatttt   180
tacgagagtt tggaagattt catatctcag atgaagggaa aactctatct gatttcgaaa   240
ttcgcggaaa aagtctattc tgaggtggat ttatcgactg acgaggacca ttattttctc   300
tttggacgtg aagacaaggg cttacctgaa gattttatgc gagaacatcc tgagaaggct   360
ctccgtattc ccatgaatga tgaacatgtc cgcagtctca atgtgtctaa taccgtctgc   420
atgattgtct atgaggctct tcgccagcag aactttgcag gtcttgagct cgtccatacc   480
tatgaagtgg ataaattgaa a                                             501

<210>   832
<211>   167
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spoU rRNA methylase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902476 (2.E-95)

<400>   832
Met Thr Asn His Ile Val Leu Phe Glu Pro Gln Ile Pro Gln Asn Thr 
1               5                   10                  15      

Gly Asn Ile Ala Arg Thr Cys Ala Ala Thr Asn Ser Pro Leu His Ile 
            20                  25                  30          

Ile Lys Pro Met Gly Phe Pro Ile Asp Asp Arg Lys Met Lys Arg Ala 
        35                  40                  45              

Gly Leu Asp Tyr Trp Asp Lys Leu Glu Ile Tyr Phe Tyr Glu Ser Leu 
    50                  55                  60                  

Glu Asp Phe Ile Ser Gln Met Lys Gly Lys Leu Tyr Leu Ile Ser Lys 
65                  70                  75                  80  

Phe Ala Glu Lys Val Tyr Ser Glu Val Asp Leu Ser Thr Asp Glu Asp 
                85                  90                  95      

His Tyr Phe Leu Phe Gly Arg Glu Asp Lys Gly Leu Pro Glu Asp Phe 
            100                 105                 110         

Met Arg Glu His Pro Glu Lys Ala Leu Arg Ile Pro Met Asn Asp Glu 
        115                 120                 125             

His Val Arg Ser Leu Asn Val Ser Asn Thr Val Cys Met Ile Val Tyr 
    130                 135                 140                 

Glu Ala Leu Arg Gln Gln Asn Phe Ala Gly Leu Glu Leu Val His Thr 
145                 150                 155                 160 

Tyr Glu Val Asp Lys Leu Lys 
                165         

<210>   833
<211>   216
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   833
ttggaaagga ttcctctatc tattctcact ttttatatcc caaaagttcc ctcttactct   60
attaaagaaa aacaaagcaa gtggttacaa tccggctata aatctatcaa aacagacaag   120
gctattcttt cgtcttctcc catccagact atactgtcgg ttgtggaatc tcaccacatc   180
agcttgcgct cacggacttc tttaaagaga aggaaa                             216

<210>   834
<211>   72
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   834
Met Glu Arg Ile Pro Leu Ser Ile Leu Thr Phe Tyr Ile Pro Lys Val 
1               5                   10                  15      

Pro Ser Tyr Ser Ile Lys Glu Lys Gln Ser Lys Trp Leu Gln Ser Gly 
            20                  25                  30          

Tyr Lys Ser Ile Lys Thr Asp Lys Ala Ile Leu Ser Ser Ser Pro Ile 
        35                  40                  45              

Gln Thr Ile Leu Ser Val Val Glu Ser His His Ile Ser Leu Arg Ser 
    50                  55                  60                  

Arg Thr Ser Leu Lys Arg Arg Lys 
65                  70          

<210>   835
<211>   561
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   835
atgacaaaca cacgtcgact ttcgaccatt gcaattctat cagccatctc atttgtgctg   60
atgtactttg actttccgct tttaccagcg gcatctttcc tcaagatcga atttagtatc   120
ttgccagtcc ttgtgggtct ggtggtcatg gatttgcctg ctgctctagg agtgctcttg   180
cttcgctcac tcttgaaatt gcttcttaac agccaaggag tgaatactta cattggtttg   240
ccgatgaata tcgtagcttt gggagttttt gtcatcgtat ttgctttgat ttggaaaaag   300
gaacggacaa cccttcgttt cctactaggc tctctagctg gaactattgg tttaaccttg   360
gccatgttgg ttctcaacta tgtttatgct gttcctttgt acgctaagtt tgctaacttt   420
gatattggaa aaattttggg actttccaac tacctaatga ccatggtatt accttttaac   480
ttgattgaag gtgttatctt ttccgtttca ttctggttgt tgtatgttct cttgaaacca   540
accttaaaac attatgagag a                                             561

<210>   836
<211>   187
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902477 (e-101)

<400>   836
Met Thr Asn Thr Arg Arg Leu Ser Thr Ile Ala Ile Leu Ser Ala Ile 
1               5                   10                  15      

Ser Phe Val Leu Met Tyr Phe Asp Phe Pro Leu Leu Pro Ala Ala Ser 
            20                  25                  30          

Phe Leu Lys Ile Glu Phe Ser Ile Leu Pro Val Leu Val Gly Leu Val 
        35                  40                  45              

Val Met Asp Leu Pro Ala Ala Leu Gly Val Leu Leu Leu Arg Ser Leu 
    50                  55                  60                  

Leu Lys Leu Leu Leu Asn Ser Gln Gly Val Asn Thr Tyr Ile Gly Leu 
65                  70                  75                  80  

Pro Met Asn Ile Val Ala Leu Gly Val Phe Val Ile Val Phe Ala Leu 
                85                  90                  95      

Ile Trp Lys Lys Glu Arg Thr Thr Leu Arg Phe Leu Leu Gly Ser Leu 
            100                 105                 110         

Ala Gly Thr Ile Gly Leu Thr Leu Ala Met Leu Val Leu Asn Tyr Val 
        115                 120                 125             

Tyr Ala Val Pro Leu Tyr Ala Lys Phe Ala Asn Phe Asp Ile Gly Lys 
    130                 135                 140                 

Ile Leu Gly Leu Ser Asn Tyr Leu Met Thr Met Val Leu Pro Phe Asn 
145                 150                 155                 160 

Leu Ile Glu Gly Val Ile Phe Ser Val Ser Phe Trp Leu Leu Tyr Val 
                165                 170                 175     

Leu Leu Lys Pro Thr Leu Lys His Tyr Glu Arg 
            180                 185         

<210>   837
<211>   648
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   837
atgagagata aacaaacatt tttaatgaag ggcagttttg cccttttact tttcgttatt   60
cttggctaca tggtcaaatt ttaccctgaa atgttggtca attttgacca atcgattcag   120
actgccattc gaggagactt accagattat ttgactattc tttttcgagc cctcacacgt   180
ctgattgata tcccagtgat tatcacttgg gttgtcatta cagcttttgt cttttatcgt   240
aagcgatgga agatagaaag tttcttcatg ctgggaaatc tggctttggc aggtctttta   300
atcgtgacct ttaaaaatat ctaccagcgc ccacgaccag ctattttaca tctggtggag   360
gagaagggat tttccttccc aagtgggcat tctctagctg taacgctgat ggtagggact   420
ttgattgtta ttcttagtca gcggattaaa gatcaggtct ggagaaaaat cgtacaaatc   480
gtccttggcc tctacctagt cagtgtgctg gtatcaagag tctatctggg agttcattac   540
ccatcagacg tccttgccag tctctgtgtg ggcttgggag tcctgtttat cgagtttccc   600
ttttatgaca agctccgctt ccaatggcga tttaaaggca aacagaag                648

<210>   838
<211>   216
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PAP2 family protein
<223>   Cellular location: membrane
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15902478 (e-119)

<400>   838
Met Arg Asp Lys Gln Thr Phe Leu Met Lys Gly Ser Phe Ala Leu Leu 
1               5                   10                  15      

Leu Phe Val Ile Leu Gly Tyr Met Val Lys Phe Tyr Pro Glu Met Leu 
            20                  25                  30          

Val Asn Phe Asp Gln Ser Ile Gln Thr Ala Ile Arg Gly Asp Leu Pro 
        35                  40                  45              

Asp Tyr Leu Thr Ile Leu Phe Arg Ala Leu Thr Arg Leu Ile Asp Ile 
    50                  55                  60                  

Pro Val Ile Ile Thr Trp Val Val Ile Thr Ala Phe Val Phe Tyr Arg 
65                  70                  75                  80  

Lys Arg Trp Lys Ile Glu Ser Phe Phe Met Leu Gly Asn Leu Ala Leu 
                85                  90                  95      

Ala Gly Leu Leu Ile Val Thr Phe Lys Asn Ile Tyr Gln Arg Pro Arg 
            100                 105                 110         

Pro Ala Ile Leu His Leu Val Glu Glu Lys Gly Phe Ser Phe Pro Ser 
        115                 120                 125             

Gly His Ser Leu Ala Val Thr Leu Met Val Gly Thr Leu Ile Val Ile 
    130                 135                 140                 

Leu Ser Gln Arg Ile Lys Asp Gln Val Trp Arg Lys Ile Val Gln Ile 
145                 150                 155                 160 

Val Leu Gly Leu Tyr Leu Val Ser Val Leu Val Ser Arg Val Tyr Leu 
                165                 170                 175     

Gly Val His Tyr Pro Ser Asp Val Leu Ala Ser Leu Cys Val Gly Leu 
            180                 185                 190         


Gly Val Leu Phe Ile Glu Phe Pro Phe Tyr Asp Lys Leu Arg Phe Gln 
        195                 200                 205             

Trp Arg Phe Lys Gly Lys Gln Lys 
    210                 215     

<210>   839
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   839
atgaaagtca atatagcaga tcttcatctg actcaactat atttatcaga aaagaagttg   60
caagatattc agatgcttta ccagtcggca gaaacaatcc aagtcgatcc aatcagtatt   120
cttgcctttg gagattgttt gctgattaca gatgggcatc acagggctta tcaggcttta   180

ttggcaggtc gggatacgat ttctgctgag tgggatagag atggtggtga tgaactatat   240
catctctatg cgcaagcttg cgaggaaaga aagatttact ctgtttttga tttagaagat   300
cgtatcctag ctcaagatgg gtatgaagca aaatggtata actggtgtga tggttttaat   360
caagcagcaa ctcttttgtt gaaaagg                                       387

<210>   840
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902479 (5.E-72)

<400>   840
Met Lys Val Asn Ile Ala Asp Leu His Leu Thr Gln Leu Tyr Leu Ser 
1               5                   10                  15      

Glu Lys Lys Leu Gln Asp Ile Gln Met Leu Tyr Gln Ser Ala Glu Thr 
            20                  25                  30          

Ile Gln Val Asp Pro Ile Ser Ile Leu Ala Phe Gly Asp Cys Leu Leu 
        35                  40                  45              

Ile Thr Asp Gly His His Arg Ala Tyr Gln Ala Leu Leu Ala Gly Arg 
    50                  55                  60                  

Asp Thr Ile Ser Ala Glu Trp Asp Arg Asp Gly Gly Asp Glu Leu Tyr 
65                  70                  75                  80  

His Leu Tyr Ala Gln Ala Cys Glu Glu Arg Lys Ile Tyr Ser Val Phe 
                85                  90                  95      

Asp Leu Glu Asp Arg Ile Leu Ala Gln Asp Gly Tyr Glu Ala Lys Trp 
            100                 105                 110         

Tyr Asn Trp Cys Asp Gly Phe Asn Gln Ala Ala Thr Leu Leu Leu Lys 
        115                 120                 125             

Arg 
    

<210>   841
<211>   153
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   841
ttgtgttttg ttccttatta taaggtcaat cattgtgagg aagcttttgc ttggtatcag   60
gatgtgaact tggtttacct cgtagatggg gtgaagcttc cttacagtca agccgacctt   120
ggaagccatg tattcctatt tggatcggca tgg                                153

<210>   842
<211>   51
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902480 (3.E-20)

<400>   842
Met Cys Phe Val Pro Tyr Tyr Lys Val Asn His Cys Glu Glu Ala Phe 
1               5                   10                  15      

Ala Trp Tyr Gln Asp Val Asn Leu Val Tyr Leu Val Asp Gly Val Lys 
            20                  25                  30          

Leu Pro Tyr Ser Gln Ala Asp Leu Gly Ser His Val Phe Leu Phe Gly 
        35                  40                  45              

Ser Ala Trp 
    50      

<210>   843
<211>   321
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   843
atgtattcct atttggatcg gcatggtgag cttttttgga ttgaagtcaa ggagaaggga   60
gaatggtttc caattgggga tattacacta tctcaggata atctccccat tgtgattggg   120
aattccgctt accaacatcg aggacttgga aaaaagattc taagtgcttt gattgaattg   180
gctcgagtaa aaggatggaa agaattgaga gtcaagaaaa tctacaccta caatcatgct   240
tctaggaggt gtttcaagtc gcttggattt gtggaaaatg gagcaacaga aaaaggaatg   300
agttttatat tggaattagt c                                             321

<210>   844
<211>   107
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902480 (1.E-58)

<400>   844
Met Tyr Ser Tyr Leu Asp Arg His Gly Glu Leu Phe Trp Ile Glu Val 
1               5                   10                  15      

Lys Glu Lys Gly Glu Trp Phe Pro Ile Gly Asp Ile Thr Leu Ser Gln 
            20                  25                  30          

Asp Asn Leu Pro Ile Val Ile Gly Asn Ser Ala Tyr Gln His Arg Gly 
        35                  40                  45              

Leu Gly Lys Lys Ile Leu Ser Ala Leu Ile Glu Leu Ala Arg Val Lys 
    50                  55                  60                  

Gly Trp Lys Glu Leu Arg Val Lys Lys Ile Tyr Thr Tyr Asn His Ala 
65                  70                  75                  80  

Ser Arg Arg Cys Phe Lys Ser Leu Gly Phe Val Glu Asn Gly Ala Thr 
                85                  90                  95      

Glu Lys Gly Met Ser Phe Ile Leu Glu Leu Val 
            100                 105         

<210>   845
<211>   600
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   845
atgaggagaa acgctttgga attagaagta tttgctgggc aagaaaaaag tgaactatct   60
atgattgagg tagcgcgtgc tatcttggaa cttcgtggtc gcgatcatga gatgcatttt   120
agcgatcttg taaacgaaat tcaaaactac cttggaacat caaacagcga tatccgcgaa   180
gctttgcctt tgttctacac agagttgaac tttgacggta gcttcatctc acttggggac   240
aacaaatggg gtcttcgttc atggtatggt gtggacgaaa tcgacgaaga aatcatcgct   300
cttgaagaaa atgacgacga tgaagtagca ccaaaagcta agaaaaaacg tgtcaatgcc   360
tttatggatg gtgattcaga tgccattgac tacaatgcag atgatccaga agacgaagat   420
gcatacgaag cagatccagc tctttcatac gatgatgaaa atccagatga tgaaaaaaat   480
gaagtggaag cttatgatgc agaaatcaac gaaatcgctc cagatgactt gggagaagat   540
gtggatctca acgaagacga cgacgagttt tcagatgacg atgctgaaac cagcgaggaa   600

<210>   846
<211>   200
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-directed RNA polymerase, delta subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902481 (e-115)

<400>   846
Met Arg Arg Asn Ala Leu Glu Leu Glu Val Phe Ala Gly Gln Glu Lys 
1               5                   10                  15      

Ser Glu Leu Ser Met Ile Glu Val Ala Arg Ala Ile Leu Glu Leu Arg 
            20                  25                  30          

Gly Arg Asp His Glu Met His Phe Ser Asp Leu Val Asn Glu Ile Gln 
        35                  40                  45              

Asn Tyr Leu Gly Thr Ser Asn Ser Asp Ile Arg Glu Ala Leu Pro Leu 
    50                  55                  60                  

Phe Tyr Thr Glu Leu Asn Phe Asp Gly Ser Phe Ile Ser Leu Gly Asp 
65                  70                  75                  80  

Asn Lys Trp Gly Leu Arg Ser Trp Tyr Gly Val Asp Glu Ile Asp Glu 
                85                  90                  95      

Glu Ile Ile Ala Leu Glu Glu Asn Asp Asp Asp Glu Val Ala Pro Lys 
            100                 105                 110         

Ala Lys Lys Lys Arg Val Asn Ala Phe Met Asp Gly Asp Ser Asp Ala 
        115                 120                 125             

Ile Asp Tyr Asn Ala Asp Asp Pro Glu Asp Glu Asp Ala Tyr Glu Ala 
    130                 135                 140                 

Asp Pro Ala Leu Ser Tyr Asp Asp Glu Asn Pro Asp Asp Glu Lys Asn 
145                 150                 155                 160 

Glu Val Glu Ala Tyr Asp Ala Glu Ile Asn Glu Ile Ala Pro Asp Asp 
                165                 170                 175     

Leu Gly Glu Asp Val Asp Leu Asn Glu Asp Asp Asp Glu Phe Ser Asp 
            180                 185                 190         

Asp Asp Ala Glu Thr Ser Glu Glu 
        195                 200 

<210>   847
<211>   135
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   847
gtgttcctga ctttgtcagt cttatctaca acctcaaaac agtgttttga gcagcctacg   60
gctagtttcc tagcttgctc tttgattttc attgagtata aaatacaaga agataacttc   120
ttgaaaaaac aaaaa                                                    135

<210>   848
<211>   45
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   848
Met Phe Leu Thr Leu Ser Val Leu Ser Thr Thr Ser Lys Gln Cys Phe 
1               5                   10                  15      

Glu Gln Pro Thr Ala Ser Phe Leu Ala Cys Ser Leu Ile Phe Ile Glu 
            20                  25                  30          

Tyr Lys Ile Gln Glu Asp Asn Phe Leu Lys Lys Gln Lys 
        35                  40                  45  

<210>   849
<211>   1605
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   849
atgtctacga aatatatttt tgtaactggt ggtgtggtat cgtccattgg gaaagggatt   60
gtggcagcga gtctaggccg tctcttgaaa aatcgtggtc tcaaagtaac cattcaaaag   120
tttgaccctt atatcaatat tgatccggga accatgagtc cttaccagca cggggaagtt   180
tttgtgacag atgacggagc tgagacagat ttggacttgg gtcactatga acgtttcatc   240
gatatcaatc tcaacaaata ttccaacgtg acaactggga aaatttacag tgaagttctt   300
cgtaaagaac gccgtggaga ataccttggg gcaactgttc aagtcattcc tcatatcaca   360
gatgctttga aagaaaaaat caagcgtgcc gctctaacga ccgactctga tgtcattatc   420
acagaggttg gtggaacagt aggagatatc gagtccttgc cattcctaga ggctcttcgt   480
cagatgaagg cagatgtggg tgcggataat gtcatgtata tccatacaac cttgcttcct   540
tacctcaagg ctgctggtga aatgaaaacc aaaccaaccc aacactctgt caaagaattg   600
cgtggcttgg gaatccaacc aaatatgttg gttattcgta cagaagagcc agctggtcaa   660
ggaattaaaa ataaactggc ccagttctgt gatgtggcac cagaagccgt tatcgaatcg   720
ttggatgttg aacaccttta ccaaattcca ctgaacttgc aggcacaagg gatggaccaa   780
attgtttgtg atcatttgaa attagacgca ccagcagcgg atatgacaga atggtcagcc   840
atggtggaca aggtcatgaa cctcaagaaa caagttaaga tttcccttgt tggtaagtat   900
gtggagttgc aagatgccta tatctcagtg gtcgaagcct tgaaacactc tggctatgtc   960
aatgatgcag aagttaaaat caattgggtc aatgccaatg atgtgacagc agagaatgta   1020
gcagaactct tgtctgatgc ggacgggatc atcgtaccag gtggttttgg tcaacgtggt   1080
acagaaggga aaatccaagc catccgctat gcgcgtgaaa atgatgttcc aatgttggga   1140
gtctgcttgg gaatgcagtt gacatgtatc gagtttgctc gtcacgtttt aggtcttgaa   1200
ggtgccaatt ctgcagagct tgcaccagaa acaaaatacc ctatcattga tatcatgcgt   1260
gatcagattg atattgagga tatgggtgga acccttcgtt tgggacttta tccgtctaag   1320
ttgaaacgtg gctctaaggc tgctgctgct tatcacaatc aagaagtggt gcaacgccgt   1380
caccgtcacc gttatgagtt taataatgcc ttccgtgagc agtttgaggc agcaggtttt   1440
gtcttttcag gagtttctcc agacaatcgt ttggtagaaa tcgtggaaat tcctgaaaat   1500
aaattctttg tagcttgtca gtatcaccct gaactgtcaa gccgtccaaa ccgaccagaa   1560
gaactctaca ctgcctttgt tactgcagca gttgagaaca gcaat                   1605

<210>   850
<211>   535
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   CTP synthase (pyrG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902482 (0.E+01)

<400>   850
Met Ser Thr Lys Tyr Ile Phe Val Thr Gly Gly Val Val Ser Ser Ile 
1               5                   10                  15      

Gly Lys Gly Ile Val Ala Ala Ser Leu Gly Arg Leu Leu Lys Asn Arg 
            20                  25                  30          

Gly Leu Lys Val Thr Ile Gln Lys Phe Asp Pro Tyr Ile Asn Ile Asp 
        35                  40                  45              

Pro Gly Thr Met Ser Pro Tyr Gln His Gly Glu Val Phe Val Thr Asp 
    50                  55                  60                  

Asp Gly Ala Glu Thr Asp Leu Asp Leu Gly His Tyr Glu Arg Phe Ile 
65                  70                  75                  80  

Asp Ile Asn Leu Asn Lys Tyr Ser Asn Val Thr Thr Gly Lys Ile Tyr 
                85                  90                  95      

Ser Glu Val Leu Arg Lys Glu Arg Arg Gly Glu Tyr Leu Gly Ala Thr 
            100                 105                 110         

Val Gln Val Ile Pro His Ile Thr Asp Ala Leu Lys Glu Lys Ile Lys 
        115                 120                 125             

Arg Ala Ala Leu Thr Thr Asp Ser Asp Val Ile Ile Thr Glu Val Gly 
    130                 135                 140                 

Gly Thr Val Gly Asp Ile Glu Ser Leu Pro Phe Leu Glu Ala Leu Arg 
145                 150                 155                 160 

Gln Met Lys Ala Asp Val Gly Ala Asp Asn Val Met Tyr Ile His Thr 
                165                 170                 175     

Thr Leu Leu Pro Tyr Leu Lys Ala Ala Gly Glu Met Lys Thr Lys Pro 
            180                 185                 190         

Thr Gln His Ser Val Lys Glu Leu Arg Gly Leu Gly Ile Gln Pro Asn 
        195                 200                 205             

Met Leu Val Ile Arg Thr Glu Glu Pro Ala Gly Gln Gly Ile Lys Asn 
    210                 215                 220                 

Lys Leu Ala Gln Phe Cys Asp Val Ala Pro Glu Ala Val Ile Glu Ser 
225                 230                 235                 240 

Leu Asp Val Glu His Leu Tyr Gln Ile Pro Leu Asn Leu Gln Ala Gln 
                245                 250                 255     

Gly Met Asp Gln Ile Val Cys Asp His Leu Lys Leu Asp Ala Pro Ala 
            260                 265                 270         

Ala Asp Met Thr Glu Trp Ser Ala Met Val Asp Lys Val Met Asn Leu 
        275                 280                 285             

Lys Lys Gln Val Lys Ile Ser Leu Val Gly Lys Tyr Val Glu Leu Gln 
    290                 295                 300                 

Asp Ala Tyr Ile Ser Val Val Glu Ala Leu Lys His Ser Gly Tyr Val 
305                 310                 315                 320 

Asn Asp Ala Glu Val Lys Ile Asn Trp Val Asn Ala Asn Asp Val Thr 
                325                 330                 335     

Ala Glu Asn Val Ala Glu Leu Leu Ser Asp Ala Asp Gly Ile Ile Val 
            340                 345                 350         

Pro Gly Gly Phe Gly Gln Arg Gly Thr Glu Gly Lys Ile Gln Ala Ile 
        355                 360                 365             

Arg Tyr Ala Arg Glu Asn Asp Val Pro Met Leu Gly Val Cys Leu Gly 
    370                 375                 380                 


Met Gln Leu Thr Cys Ile Glu Phe Ala Arg His Val Leu Gly Leu Glu 
385                 390                 395                 400 

Gly Ala Asn Ser Ala Glu Leu Ala Pro Glu Thr Lys Tyr Pro Ile Ile 
                405                 410                 415     

Asp Ile Met Arg Asp Gln Ile Asp Ile Glu Asp Met Gly Gly Thr Leu 
            420                 425                 430         

Arg Leu Gly Leu Tyr Pro Ser Lys Leu Lys Arg Gly Ser Lys Ala Ala 
        435                 440                 445             

Ala Ala Tyr His Asn Gln Glu Val Val Gln Arg Arg His Arg His Arg 
    450                 455                 460                 

Tyr Glu Phe Asn Asn Ala Phe Arg Glu Gln Phe Glu Ala Ala Gly Phe 
465                 470                 475                 480 

Val Phe Ser Gly Val Ser Pro Asp Asn Arg Leu Val Glu Ile Val Glu 
                485                 490                 495     

Ile Pro Glu Asn Lys Phe Phe Val Ala Cys Gln Tyr His Pro Glu Leu 
            500                 505                 510         

Ser Ser Arg Pro Asn Arg Pro Glu Glu Leu Tyr Thr Ala Phe Val Thr 
        515                 520                 525             

Ala Ala Val Glu Asn Ser Asn 
    530                 535 

<210>   851
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   851
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattgtt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg tgggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   852
<211>   448

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   852
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   853
<211>   1629
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   853
atgtccatta attggcagga aattttattt cactttttag gtggtctggg gctattctta   60
tatagcatca agaccatggg agacggttta caacaagctg ctggagatcg ccttcgtttt   120
tacattgaca aatatactag taatcctttc tttggagttc tggttggtat tgggatgact   180
gctctaattc agtctagttc tggtgtaaca gttatcacag tcggcctggt cagtgccggt   240
ctcttaacct tacgtcaggc tatcgggatt gtcatgggtg ctaatattgg gacaactgtc   300
acatcctttc tcatcggttt taaattaggt aactatgccc tacctatgct ctttatcggt   360
gccgtctgtc ttttttttac gaaaaatcgg acagtcaata atatcggacg catcctcttt   420
ggtgtcggtg gtatcttttt tgccctcaat ctcatgagcg gcgcaatggc tccactcaag   480
gatttacagg tctttaagga ctatatgatt gagctaagta agaatcctgt tttgggtgtc   540
tttgtcggta ctggcttgac cttgctaatt caagcttctt cggctaccat tgggatttta   600
caaaacctct acgccggcaa tctaattgat ctacagggag ctttgccagt tctatttggt   660
gacaatatcg ggacaaccat tacagccatc attgcctctt taggggctaa tattgcagct   720
aaacgggtag caggagctca tgttgccttc aacgttatcg gaacagttgt ctgcgttatt   780
tttctagttc cttttactgt cctgattcat tggtttgaag ctacgctaaa tctagcaccg   840
gaaatgacca tcgcctttgc tcacggaacc tttaatatta ccaacaccat tgtccaattt   900
ccatttatcg gagctctggc ttactttgta accaagatta ttcctggaga ggacgaggtt   960
gtcaaatacg aacccttata tcttgatgaa catttcatca aacaggcccc atctatcgct   1020
ctaggaaatg ctaagaaaga gctcttgcac ttaggaaact acgctgctaa agcctttgac   1080
ctttcctata agtacatcat tgacttggat gaaaaagttg ctgaaaaagg gcataaaacc   1140
gaagaagcaa ttaacaccat cgatgagcaa ttaacacgtt atctcattgc cctttcaagc   1200
gaagctctca gccaaaaaga aagtgaagtg cttaccaata tccttgattc ctcccgtgat   1260
ttggaacgga ttggagacca cacggaggct ctactcaatc tgactgacta tcttcaacgg   1320
aaaaatgttg aattttctga tgccgccttg aaagaattag aggaagttta ccgccaaact   1380
agtgacttta tcaaagatgc tctggatagt gtggaaaaca atgatattga aaaagcacgc   1440
agtcttgtag aacgtcatga agcaatcaat aagatagaac gtgttctcag aaaaacccac   1500
atcaaacgcc tcaacaaagg cgaatgttca acacaagctg gggtcaactt tatcgacatc   1560
atctcacact acactcgtgt atcagaccac gctatgaacc ttgctgaaaa ggtttttgca   1620
gaacaaatc                                                           1629

<210>   854
<211>   543
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Na/Pi cotransporter II-related protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902483 (0.E+01)

<400>   854
Met Ser Ile Asn Trp Gln Glu Ile Leu Phe His Phe Leu Gly Gly Leu 
1               5                   10                  15      

Gly Leu Phe Leu Tyr Ser Ile Lys Thr Met Gly Asp Gly Leu Gln Gln 
            20                  25                  30          

Ala Ala Gly Asp Arg Leu Arg Phe Tyr Ile Asp Lys Tyr Thr Ser Asn 
        35                  40                  45              

Pro Phe Phe Gly Val Leu Val Gly Ile Gly Met Thr Ala Leu Ile Gln 
    50                  55                  60                  

Ser Ser Ser Gly Val Thr Val Ile Thr Val Gly Leu Val Ser Ala Gly 
65                  70                  75                  80  

Leu Leu Thr Leu Arg Gln Ala Ile Gly Ile Val Met Gly Ala Asn Ile 
                85                  90                  95      

Gly Thr Thr Val Thr Ser Phe Leu Ile Gly Phe Lys Leu Gly Asn Tyr 
            100                 105                 110         

Ala Leu Pro Met Leu Phe Ile Gly Ala Val Cys Leu Phe Phe Thr Lys 
        115                 120                 125             

Asn Arg Thr Val Asn Asn Ile Gly Arg Ile Leu Phe Gly Val Gly Gly 
    130                 135                 140                 

Ile Phe Phe Ala Leu Asn Leu Met Ser Gly Ala Met Ala Pro Leu Lys 
145                 150                 155                 160 

Asp Leu Gln Val Phe Lys Asp Tyr Met Ile Glu Leu Ser Lys Asn Pro 
                165                 170                 175     

Val Leu Gly Val Phe Val Gly Thr Gly Leu Thr Leu Leu Ile Gln Ala 
            180                 185                 190         

Ser Ser Ala Thr Ile Gly Ile Leu Gln Asn Leu Tyr Ala Gly Asn Leu 
        195                 200                 205             

Ile Asp Leu Gln Gly Ala Leu Pro Val Leu Phe Gly Asp Asn Ile Gly 
    210                 215                 220                 

Thr Thr Ile Thr Ala Ile Ile Ala Ser Leu Gly Ala Asn Ile Ala Ala 
225                 230                 235                 240 

Lys Arg Val Ala Gly Ala His Val Ala Phe Asn Val Ile Gly Thr Val 
                245                 250                 255     

Val Cys Val Ile Phe Leu Val Pro Phe Thr Val Leu Ile His Trp Phe 
            260                 265                 270         

Glu Ala Thr Leu Asn Leu Ala Pro Glu Met Thr Ile Ala Phe Ala His 
        275                 280                 285             

Gly Thr Phe Asn Ile Thr Asn Thr Ile Val Gln Phe Pro Phe Ile Gly 
    290                 295                 300                 

Ala Leu Ala Tyr Phe Val Thr Lys Ile Ile Pro Gly Glu Asp Glu Val 
305                 310                 315                 320 

Val Lys Tyr Glu Pro Leu Tyr Leu Asp Glu His Phe Ile Lys Gln Ala 
                325                 330                 335     

Pro Ser Ile Ala Leu Gly Asn Ala Lys Lys Glu Leu Leu His Leu Gly 
            340                 345                 350         

Asn Tyr Ala Ala Lys Ala Phe Asp Leu Ser Tyr Lys Tyr Ile Ile Asp 
        355                 360                 365             

Leu Asp Glu Lys Val Ala Glu Lys Gly His Lys Thr Glu Glu Ala Ile 
    370                 375                 380                 

Asn Thr Ile Asp Glu Gln Leu Thr Arg Tyr Leu Ile Ala Leu Ser Ser 
385                 390                 395                 400 

Glu Ala Leu Ser Gln Lys Glu Ser Glu Val Leu Thr Asn Ile Leu Asp 
                405                 410                 415     

Ser Ser Arg Asp Leu Glu Arg Ile Gly Asp His Thr Glu Ala Leu Leu 
            420                 425                 430         

Asn Leu Thr Asp Tyr Leu Gln Arg Lys Asn Val Glu Phe Ser Asp Ala 
        435                 440                 445             

Ala Leu Lys Glu Leu Glu Glu Val Tyr Arg Gln Thr Ser Asp Phe Ile 
    450                 455                 460                 

Lys Asp Ala Leu Asp Ser Val Glu Asn Asn Asp Ile Glu Lys Ala Arg 
465                 470                 475                 480 

Ser Leu Val Glu Arg His Glu Ala Ile Asn Lys Ile Glu Arg Val Leu 
                485                 490                 495     

Arg Lys Thr His Ile Lys Arg Leu Asn Lys Gly Glu Cys Ser Thr Gln 
            500                 505                 510         

Ala Gly Val Asn Phe Ile Asp Ile Ile Ser His Tyr Thr Arg Val Ser 
        515                 520                 525             

Asp His Ala Met Asn Leu Ala Glu Lys Val Phe Ala Glu Gln Ile 
    530                 535                 540             

<210>   855
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   855
gtgattatca tggttctaga gtttgataaa aaactacaga atataaagcg ctttcttgaa   60
aacaacaaaa tcaatctttt aggaggagaa aatgaagaat ccattttt                108

<210>   856
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   856
Met Ile Ile Met Val Leu Glu Phe Asp Lys Lys Leu Gln Asn Ile Lys 
1               5                   10                  15      

Arg Phe Leu Glu Asn Asn Lys Ile Asn Leu Leu Gly Gly Glu Asn Glu 
            20                  25                  30          

Glu Ser Ile Phe 
        35      

<210>   857
<211>   4977
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   857
atgaagaatc cattttttga aagacgttgt cgttacagta ttcgtaagtt atcagtagga   60
gcctgctcgc tgatgattgg tgctgtttta tttgctggtc cagccttggc tgaagaaact   120
gcagttcctg aaaatagcgg agctaataca gagcttgttt caggagagag tgagcattcg   180
accaatgaag ctgataagca gaatgaaggg gaacatgcta gagaaaacaa gctagaaaag   240
gcagaaggag tagcgatagc atctgaaact gcttcgccag caagcaatga agctgcaact   300
actgaaactg cagaagcagc tagcgcagct aaaccagagg aaaaagcaag tgaggtggtt   360
gcagaaacac catctgcaga agcaaaacct aagtctgaca aggaaacaga agcaaagccc   420
gaagcaacta accaagggga tgagtctaaa ccagcagcag aagctaataa gactgaaaaa   480
gaagtccagc cagatgtccc taaaaataca gaaaaaacat taaaaccaaa ggaaatcaaa   540
tttaattctt gggaagaatt gttaaaatgg gaaccaggtg ctcgtgaaga tgatgctatt   600
aaccgcggat ctgttgtcct cgcttcacgt cggacaggtc atttagtcaa tgaaaaagct   660
agcaaggaag caaaagttca agccttatca aacaccaatt ctaaagcaaa agaccatgct   720
tctgttggtg gagaagagtt caaggcctat gcttttgact attggcaata tctagattca   780
atggtcttct gggaaggtct cgtaccaact cctgacgtta ttgatgcagg tcaccgtaac   840
ggggttcctg tatacggtac actcttcttc aactggtcta atagtattgc agatcaagaa   900
agatttgctg aagctttgaa gcaagacgca gatggtagct tcccaattgc ccgtaaattg   960
gtagacatgg ccaagtatta tggctatgat ggctatttca tcaaccaaga aacaactgga   1020
gatttggtta aacctcttgg agaaaagatg cgccagttta tgctctatag caaggaatat   1080
gctgctaagg taaaccatcc aatcaagtat tcttggtacg atgccatgac ctataactat   1140
ggacgttatc atcaagatgg tttgggagaa tacaactacc aattcatgca accagaagga   1200
gataaggttc cggcagataa cttctttgct aactttaact gggataaggc taaaaatgat   1260
tacactattg caactgccaa ctggattggt cgtaatcctt atgatgtatt tgcaggtttg   1320
gaattgcaac agggtggttc ctacaagaca aaggttaagt ggaatgacat tttagacgaa   1380
aatgggaaat tgcgcctttc tcttggttta tttgccccag ataccattac aagtttagga   1440
aaaactggtg aagattatca taaaaatgaa gatatcttct ttacaggtta tcaaggagac   1500
cctactggcc aaaaaccagg tgacaaagat tggtatggta ttgctaacct agttgcggac   1560
cgtacgccag cggtaggtaa tacttttact acttctttta atacaggtca tggtaaaaaa   1620
tggttcgtag atggtaaggt ttctaaggat tctgagtgga attatcgttc agtatcaggt   1680
gttcttccaa catggcgctg gtggcagact tcaacagggg aaaaacttcg tgcagaatat   1740
gattttacag atgcctataa tggcggaaat tcccttaaat tctctggtga tgtagccggt   1800
aagacagatc aggatgtgag actttattct actaagttag aagtaactga gaagaccaaa   1860
cttcgtgttg cccacaaggg aggaaaaggt tctaaagttt atatggcatt ctctacaact   1920
ccagactaca aattcgatga tgcagatgca tggaaagagc taaccctttc tgacaactgg   1980
acaaatgaag aatttgatct tagctcacta gcgggtaaaa ccatctatgc agtcaaacta   2040
tttttcgagc atgaaggtgc tgtaaaagat tatcagttta acctaggaca attaactatc   2100
tcggacaatc accaagagcc acaatcgccg acaagctttt ctgtagtgaa acaatctctt   2160
aaaaatgccc aagaagcgga agcagttgtg caatttaaag gcaacaagga tgcagatttc   2220
tatgaagttt atgaaaaaga tggagacagc tggaaattac taactggctc atcttctaca   2280
actatttatc taccaaaagt tagccgctca gcaagtgctc agggtacaac tcaagaactg   2340
aaggttgtag cagtcggtaa aaatggagtt cgttcagaag ctgcaaccac aacctttgat   2400
tggggtatga ctgtaaaaga taccagccta ccaaaaccac tagctgaaaa tatcgttcca   2460
ggtgcaacag ttattgatag tactttccct aagactgaag gtggagaagg tattgaaggt   2520
atgttgaacg gtaccattac tagcttgtca gataaatggt cttcagctca gttgagtggt   2580
agtgtggata ttcgtttgac caagccacgt accgttgtta gatgggtcat ggatcatgca   2640
ggagctggtg gtgagtctgt taacgatggc ttgatgaaca ctaaagactt tgacctttat   2700
tataaagatg cagatggtga gtggaagcta gctaaggaag tccgtggtaa caaagcacac   2760
gtgacagata tcactcttga taaaccaatc actgctcaag actggcgctt gaatgttgtc   2820
acttctgaca atggaactcc atggaaggct attcgtatct ataactggaa aatgtatgaa   2880
aagcttgata ctgagagtgt caatattccg atggccaagg ctgcagcccg ttctctaggc   2940
aataacaagg tacaagttgg ctttgcagat gtaccggctg gagcaactat taccgtttat   3000
gataatccaa attctcaaac tccgctcgca accttgaaga gcgaagttgg aggagaccta   3060
gcaagtgcac cattggattt gacaaatcaa tctggtcttc tttattatcg tacccagttg   3120
ccaggcaagg aaattagtaa tgtcctagca gtttccgttc caaaagatga cagaagaatc   3180
aagtcagtca gcctagaaac aggacctaag aaaacaagct acgccgaagg ggaggatttg   3240
gaccttagag gtggtgttct tcgagttcag tatgaaggag gaactgagga cgaactcatt   3300
cgcctaactc acgcaggtgt atcagtatca ggttttgata cgcatcataa gggagaacag   3360
aatcttactc tccaatattt gggacaaccg gtaaatgcta atttgtcagt gactgtcact   3420
ggccaagacg aagcaagtcc gaaaactatt ttgggaattg aagtaagtca ggaaccgaaa   3480
aaagattacc tagttggtga tagcttagac ttgtctgaag gacgctttgc agtggcttat   3540
agcaatgaca ccatggaaga acattccttt actgatgagg gagttgaaat ttctggttac   3600
gatgctcaaa agactggtcg tcaaaccttg acgcttcatt accaaggcca tgaagttagc   3660
tttgatgttt tggtatctcc aaaagcagca ttgaacgatg agtacctcaa acaaaaatta   3720
gcagaagttg aagctgctaa gaacaaggtg gtctataact ttgcttcatc agaagtaaaa   3780
gaagccttct tgaaagcaat tgaagcggcc gaacaagtgt tgaaagacca tgaaactagc   3840
acccaagatc aagtcaatga ccgacttaat aaattgacag aagctcataa agctctgaat   3900
ggtcaagaga aatttacgga agaaaagaca gagcttgatc gcttaacagg tgaggttcaa   3960
gaactcttgg ctgccaaacc aaaccatcct tcaggttctg ccctagctcc gcttcttgag   4020
aaaaacaagg ccttggttga aaaagtagat ttgagtccag aagagcttac aacagcgaaa   4080
cagagtctaa aagatctggt tgctttattg aaagaagaca agccagcagt cttttctgat   4140
agtaaaacag gtgttgaagt acacttctca aataaagaga agactgtcat caagggtttg   4200
aaagtagagc gtgttcaagc aagtgctgaa gagaagaaat actttgctgg agaagatgct   4260
catgtctttg aaatagaagg tttggatgaa aaaggtcaag atgttgatct ctcttatgct   4320
tctattgtga aaatcccaat tgaaaaagat aagaaagtta agaaagtatt tttcttacct   4380
gaaggcaaag aggcagtaga attggctttt gaacaaacgg atagtcatgt tatctttaca   4440
gcacctcact ttactcatta tgcctttgtt tatgaatctg ctgaaaaacc acaacctgct   4500
aaaccagcac cacaaaacac agtccttcca aaacctactt atcaaccgac ttctgatcaa   4560
caaaaggctc ctaaattgga agttcaagag gaaaaggttg cctttcatcg tcaagagcat   4620
gaaaatactg agatgctagt tggggaacaa cgagtcatca tacagggacg agatggactg   4680
ttaagacatg tctttgaagt tgatgaaaac ggtcagcgtc gtcttcgttc aacagaagtc   4740
atccaagaag cgattccaga aattgttgaa attggaacaa aagtaaaaac agtaccagca   4800
gtagtagcta cacaggaaaa accagctcaa aatacagcag ttaaatcaga agaagcaagc   4860
aaacaattgc caaatacagg aacagctgat gctaatgaag ccctaatagc aggcttagcc   4920
agccttggtc ttgctagttt agccttgacc ttgagacgga aaagagaaga taaagat      4977

<210>   858
<211>   1659
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   endo-beta-N-acetylglucosaminidase, putative
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15902484 (0.E+01)

<400>   858
Met Lys Asn Pro Phe Phe Glu Arg Arg Cys Arg Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Leu Ser Val Gly Ala Cys Ser Leu Met Ile Gly Ala Val Leu Phe Ala 
            20                  25                  30          

Gly Pro Ala Leu Ala Glu Glu Thr Ala Val Pro Glu Asn Ser Gly Ala 
        35                  40                  45              

Asn Thr Glu Leu Val Ser Gly Glu Ser Glu His Ser Thr Asn Glu Ala 
    50                  55                  60                  

Asp Lys Gln Asn Glu Gly Glu His Ala Arg Glu Asn Lys Leu Glu Lys 
65                  70                  75                  80  

Ala Glu Gly Val Ala Ile Ala Ser Glu Thr Ala Ser Pro Ala Ser Asn 
                85                  90                  95      

Glu Ala Ala Thr Thr Glu Thr Ala Glu Ala Ala Ser Ala Ala Lys Pro 
            100                 105                 110         

Glu Glu Lys Ala Ser Glu Val Val Ala Glu Thr Pro Ser Ala Glu Ala 
        115                 120                 125             

Lys Pro Lys Ser Asp Lys Glu Thr Glu Ala Lys Pro Glu Ala Thr Asn 
    130                 135                 140                 

Gln Gly Asp Glu Ser Lys Pro Ala Ala Glu Ala Asn Lys Thr Glu Lys 
145                 150                 155                 160 

Glu Val Gln Pro Asp Val Pro Lys Asn Thr Glu Lys Thr Leu Lys Pro 
                165                 170                 175     

Lys Glu Ile Lys Phe Asn Ser Trp Glu Glu Leu Leu Lys Trp Glu Pro 
            180                 185                 190         

Gly Ala Arg Glu Asp Asp Ala Ile Asn Arg Gly Ser Val Val Leu Ala 
        195                 200                 205             

Ser Arg Arg Thr Gly His Leu Val Asn Glu Lys Ala Ser Lys Glu Ala 
    210                 215                 220                 

Lys Val Gln Ala Leu Ser Asn Thr Asn Ser Lys Ala Lys Asp His Ala 
225                 230                 235                 240 

Ser Val Gly Gly Glu Glu Phe Lys Ala Tyr Ala Phe Asp Tyr Trp Gln 
                245                 250                 255     

Tyr Leu Asp Ser Met Val Phe Trp Glu Gly Leu Val Pro Thr Pro Asp 
            260                 265                 270         

Val Ile Asp Ala Gly His Arg Asn Gly Val Pro Val Tyr Gly Thr Leu 
        275                 280                 285             

Phe Phe Asn Trp Ser Asn Ser Ile Ala Asp Gln Glu Arg Phe Ala Glu 
    290                 295                 300                 

Ala Leu Lys Gln Asp Ala Asp Gly Ser Phe Pro Ile Ala Arg Lys Leu 
305                 310                 315                 320 

Val Asp Met Ala Lys Tyr Tyr Gly Tyr Asp Gly Tyr Phe Ile Asn Gln 
                325                 330                 335     

Glu Thr Thr Gly Asp Leu Val Lys Pro Leu Gly Glu Lys Met Arg Gln 
            340                 345                 350         

Phe Met Leu Tyr Ser Lys Glu Tyr Ala Ala Lys Val Asn His Pro Ile 
        355                 360                 365             

Lys Tyr Ser Trp Tyr Asp Ala Met Thr Tyr Asn Tyr Gly Arg Tyr His 
    370                 375                 380                 

Gln Asp Gly Leu Gly Glu Tyr Asn Tyr Gln Phe Met Gln Pro Glu Gly 
385                 390                 395                 400 

Asp Lys Val Pro Ala Asp Asn Phe Phe Ala Asn Phe Asn Trp Asp Lys 
                405                 410                 415     

Ala Lys Asn Asp Tyr Thr Ile Ala Thr Ala Asn Trp Ile Gly Arg Asn 
            420                 425                 430         

Pro Tyr Asp Val Phe Ala Gly Leu Glu Leu Gln Gln Gly Gly Ser Tyr 
        435                 440                 445             

Lys Thr Lys Val Lys Trp Asn Asp Ile Leu Asp Glu Asn Gly Lys Leu 
    450                 455                 460                 

Arg Leu Ser Leu Gly Leu Phe Ala Pro Asp Thr Ile Thr Ser Leu Gly 
465                 470                 475                 480 

Lys Thr Gly Glu Asp Tyr His Lys Asn Glu Asp Ile Phe Phe Thr Gly 
                485                 490                 495     

Tyr Gln Gly Asp Pro Thr Gly Gln Lys Pro Gly Asp Lys Asp Trp Tyr 
            500                 505                 510         

Gly Ile Ala Asn Leu Val Ala Asp Arg Thr Pro Ala Val Gly Asn Thr 
        515                 520                 525             

Phe Thr Thr Ser Phe Asn Thr Gly His Gly Lys Lys Trp Phe Val Asp 
    530                 535                 540                 

Gly Lys Val Ser Lys Asp Ser Glu Trp Asn Tyr Arg Ser Val Ser Gly 
545                 550                 555                 560 

Val Leu Pro Thr Trp Arg Trp Trp Gln Thr Ser Thr Gly Glu Lys Leu 
                565                 570                 575     

Arg Ala Glu Tyr Asp Phe Thr Asp Ala Tyr Asn Gly Gly Asn Ser Leu 
            580                 585                 590         

Lys Phe Ser Gly Asp Val Ala Gly Lys Thr Asp Gln Asp Val Arg Leu 
        595                 600                 605             

Tyr Ser Thr Lys Leu Glu Val Thr Glu Lys Thr Lys Leu Arg Val Ala 
    610                 615                 620                 

His Lys Gly Gly Lys Gly Ser Lys Val Tyr Met Ala Phe Ser Thr Thr 
625                 630                 635                 640 

Pro Asp Tyr Lys Phe Asp Asp Ala Asp Ala Trp Lys Glu Leu Thr Leu 
                645                 650                 655     

Ser Asp Asn Trp Thr Asn Glu Glu Phe Asp Leu Ser Ser Leu Ala Gly 
            660                 665                 670         

Lys Thr Ile Tyr Ala Val Lys Leu Phe Phe Glu His Glu Gly Ala Val 
        675                 680                 685             

Lys Asp Tyr Gln Phe Asn Leu Gly Gln Leu Thr Ile Ser Asp Asn His 
    690                 695                 700                 

Gln Glu Pro Gln Ser Pro Thr Ser Phe Ser Val Val Lys Gln Ser Leu 
705                 710                 715                 720 

Lys Asn Ala Gln Glu Ala Glu Ala Val Val Gln Phe Lys Gly Asn Lys 
                725                 730                 735     

Asp Ala Asp Phe Tyr Glu Val Tyr Glu Lys Asp Gly Asp Ser Trp Lys 
            740                 745                 750         

Leu Leu Thr Gly Ser Ser Ser Thr Thr Ile Tyr Leu Pro Lys Val Ser 
        755                 760                 765             

Arg Ser Ala Ser Ala Gln Gly Thr Thr Gln Glu Leu Lys Val Val Ala 
    770                 775                 780                 

Val Gly Lys Asn Gly Val Arg Ser Glu Ala Ala Thr Thr Thr Phe Asp 
785                 790                 795                 800 

Trp Gly Met Thr Val Lys Asp Thr Ser Leu Pro Lys Pro Leu Ala Glu 
                805                 810                 815     

Asn Ile Val Pro Gly Ala Thr Val Ile Asp Ser Thr Phe Pro Lys Thr 
            820                 825                 830         

Glu Gly Gly Glu Gly Ile Glu Gly Met Leu Asn Gly Thr Ile Thr Ser 
        835                 840                 845             


Leu Ser Asp Lys Trp Ser Ser Ala Gln Leu Ser Gly Ser Val Asp Ile 
    850                 855                 860                 

Arg Leu Thr Lys Pro Arg Thr Val Val Arg Trp Val Met Asp His Ala 
865                 870                 875                 880 

Gly Ala Gly Gly Glu Ser Val Asn Asp Gly Leu Met Asn Thr Lys Asp 
                885                 890                 895     

Phe Asp Leu Tyr Tyr Lys Asp Ala Asp Gly Glu Trp Lys Leu Ala Lys 
            900                 905                 910         

Glu Val Arg Gly Asn Lys Ala His Val Thr Asp Ile Thr Leu Asp Lys 
        915                 920                 925             

Pro Ile Thr Ala Gln Asp Trp Arg Leu Asn Val Val Thr Ser Asp Asn 
    930                 935                 940                 

Gly Thr Pro Trp Lys Ala Ile Arg Ile Tyr Asn Trp Lys Met Tyr Glu 
945                 950                 955                 960 

Lys Leu Asp Thr Glu Ser Val Asn Ile Pro Met Ala Lys Ala Ala Ala 
                965                 970                 975     

Arg Ser Leu Gly Asn Asn Lys Val Gln Val Gly Phe Ala Asp Val Pro 
            980                 985                 990         

Ala Gly Ala Thr Ile Thr Val Tyr Asp Asn Pro Asn Ser Gln Thr Pro 
        995                 1000                1005            

Leu Ala Thr Leu Lys Ser Glu Val Gly Gly Asp Leu Ala Ser Ala Pro 
    1010                1015                1020                

Leu Asp Leu Thr Asn Gln Ser Gly Leu Leu Tyr Tyr Arg Thr Gln Leu 
1025                1030                1035                1040

Pro Gly Lys Glu Ile Ser Asn Val Leu Ala Val Ser Val Pro Lys Asp 
                1045                1050                1055    

Asp Arg Arg Ile Lys Ser Val Ser Leu Glu Thr Gly Pro Lys Lys Thr 
            1060                1065                1070        

Ser Tyr Ala Glu Gly Glu Asp Leu Asp Leu Arg Gly Gly Val Leu Arg 
        1075                1080                1085            

Val Gln Tyr Glu Gly Gly Thr Glu Asp Glu Leu Ile Arg Leu Thr His 
    1090                1095                1100                

Ala Gly Val Ser Val Ser Gly Phe Asp Thr His His Lys Gly Glu Gln 
1105                1110                1115                1120

Asn Leu Thr Leu Gln Tyr Leu Gly Gln Pro Val Asn Ala Asn Leu Ser 
                1125                1130                1135    

Val Thr Val Thr Gly Gln Asp Glu Ala Ser Pro Lys Thr Ile Leu Gly 
            1140                1145                1150        

Ile Glu Val Ser Gln Glu Pro Lys Lys Asp Tyr Leu Val Gly Asp Ser 
        1155                1160                1165            

Leu Asp Leu Ser Glu Gly Arg Phe Ala Val Ala Tyr Ser Asn Asp Thr 
    1170                1175                1180                


Met Glu Glu His Ser Phe Thr Asp Glu Gly Val Glu Ile Ser Gly Tyr 
1185                1190                1195                1200

Asp Ala Gln Lys Thr Gly Arg Gln Thr Leu Thr Leu His Tyr Gln Gly 
                1205                1210                1215    

His Glu Val Ser Phe Asp Val Leu Val Ser Pro Lys Ala Ala Leu Asn 
            1220                1225                1230        

Asp Glu Tyr Leu Lys Gln Lys Leu Ala Glu Val Glu Ala Ala Lys Asn 
        1235                1240                1245            

Lys Val Val Tyr Asn Phe Ala Ser Ser Glu Val Lys Glu Ala Phe Leu 
    1250                1255                1260                

Lys Ala Ile Glu Ala Ala Glu Gln Val Leu Lys Asp His Glu Thr Ser 
1265                1270                1275                1280

Thr Gln Asp Gln Val Asn Asp Arg Leu Asn Lys Leu Thr Glu Ala His 
                1285                1290                1295    

Lys Ala Leu Asn Gly Gln Glu Lys Phe Thr Glu Glu Lys Thr Glu Leu 
            1300                1305                1310        

Asp Arg Leu Thr Gly Glu Val Gln Glu Leu Leu Ala Ala Lys Pro Asn 
        1315                1320                1325            

His Pro Ser Gly Ser Ala Leu Ala Pro Leu Leu Glu Lys Asn Lys Ala 
    1330                1335                1340                

Leu Val Glu Lys Val Asp Leu Ser Pro Glu Glu Leu Thr Thr Ala Lys 
1345                1350                1355                1360

Gln Ser Leu Lys Asp Leu Val Ala Leu Leu Lys Glu Asp Lys Pro Ala 
                1365                1370                1375    

Val Phe Ser Asp Ser Lys Thr Gly Val Glu Val His Phe Ser Asn Lys 
            1380                1385                1390        

Glu Lys Thr Val Ile Lys Gly Leu Lys Val Glu Arg Val Gln Ala Ser 
        1395                1400                1405            

Ala Glu Glu Lys Lys Tyr Phe Ala Gly Glu Asp Ala His Val Phe Glu 
    1410                1415                1420                

Ile Glu Gly Leu Asp Glu Lys Gly Gln Asp Val Asp Leu Ser Tyr Ala 
1425                1430                1435                1440

Ser Ile Val Lys Ile Pro Ile Glu Lys Asp Lys Lys Val Lys Lys Val 
                1445                1450                1455    

Phe Phe Leu Pro Glu Gly Lys Glu Ala Val Glu Leu Ala Phe Glu Gln 
            1460                1465                1470        

Thr Asp Ser His Val Ile Phe Thr Ala Pro His Phe Thr His Tyr Ala 
        1475                1480                1485            

Phe Val Tyr Glu Ser Ala Glu Lys Pro Gln Pro Ala Lys Pro Ala Pro 
    1490                1495                1500                

Gln Asn Thr Val Leu Pro Lys Pro Thr Tyr Gln Pro Thr Ser Asp Gln 
1505                1510                1515                1520

Gln Lys Ala Pro Lys Leu Glu Val Gln Glu Glu Lys Val Ala Phe His 
                1525                1530                1535    

Arg Gln Glu His Glu Asn Thr Glu Met Leu Val Gly Glu Gln Arg Val 
            1540                1545                1550        

Ile Ile Gln Gly Arg Asp Gly Leu Leu Arg His Val Phe Glu Val Asp 
        1555                1560                1565            

Glu Asn Gly Gln Arg Arg Leu Arg Ser Thr Glu Val Ile Gln Glu Ala 
    1570                1575                1580                

Ile Pro Glu Ile Val Glu Ile Gly Thr Lys Val Lys Thr Val Pro Ala 
1585                1590                1595                1600

Val Val Ala Thr Gln Glu Lys Pro Ala Gln Asn Thr Ala Val Lys Ser 
                1605                1610                1615    

Glu Glu Ala Ser Lys Gln Leu Pro Asn Thr Gly Thr Ala Asp Ala Asn 
            1620                1625                1630        

Glu Ala Leu Ile Ala Gly Leu Ala Ser Leu Gly Leu Ala Ser Leu Ala 
        1635                1640                1645            

Leu Thr Leu Arg Arg Lys Arg Glu Asp Lys Asp 
    1650                1655                

<210>   859
<211>   1194
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   859
atggcaaaac ttactgttaa agacgttgac ttgaaaggta aaaaagtcct cgttcgtgtt   60
gacttcaacg taccattgaa agatggcgta atcactaacg ataaccgtat cacagcagct   120
cttccaacta ttaagtacat catcgaacaa ggtggacgtg caattctttt ctctcacctt   180
ggacgtgtga aagaagaagc tgataaagct ggtaaatcac ttgctcctgt agcagctgac   240
ttggcagcaa aacttggtca agatgttgtt ttcccaggtg tcactcgtgg tgctgaatta   300
gaagcggcaa tcaacgctct tgaagatgga caagttctct tggttgaaaa cactcgttac   360
gaagatgttg acggcaagaa agaatctaaa aacgatcctg aacttggtaa atactgggca   420
tcacttggag atggtatctt cgtaaacgat gcattcggta cagctcaccg tgcacacgca   480
tctaacgttg gtatctcagc aaacgttgaa aaagcagttg ctggtttcct tcttgaaaac   540
gaaattgcct acatccaaga agcagttgaa actccagaac gtccattcgt ggctatcctt   600
ggtggttcaa aagtttcaga caagatcggt gttatcgaaa acttgcttga aaaagctgat   660
aacgtcctta tcggtggtgg gatgacttac acattctaca aagcacaagg tatcgaaatc   720
ggtaactcac ttgtagaaga agacaaattg gatgttgcga aagctcttct tgaaaaagca   780
aatggtaaat tgatcttgcc agttgactca aaagaagcta acgcatttgc tggttacact   840
gaagtgcgtg acactgaagg tgaagcagtt tctgaaggct tccttggtct tgacatcggt   900
ccaaaatcta tcgccaaatt tgacgaagct ttgactggtg ccaaaacagt cgtatggaac   960
ggacctatgg gtgtatttga aaacccagat ttccaagctg gtacaatcgg tgtgatggac   1020
gctatcgtga aacaaccagg agttaaatca atcatcggtg gtggtgactc agctgccgca   1080
gcgattaacc ttggccgtgc agacaagttc tcatggatta gtacgggtgg tggagcatca   1140
atggaacttc ttgaaggtaa ggttcttcca ggacttgcag ccttgacaga aaaa         1194

<210>   860
<211>   398
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoglycerate kinase (pgk)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902485 (0.E+01)

<400>   860
Met Ala Lys Leu Thr Val Lys Asp Val Asp Leu Lys Gly Lys Lys Val 
1               5                   10                  15      

Leu Val Arg Val Asp Phe Asn Val Pro Leu Lys Asp Gly Val Ile Thr 
            20                  25                  30          

Asn Asp Asn Arg Ile Thr Ala Ala Leu Pro Thr Ile Lys Tyr Ile Ile 
        35                  40                  45              

Glu Gln Gly Gly Arg Ala Ile Leu Phe Ser His Leu Gly Arg Val Lys 
    50                  55                  60                  

Glu Glu Ala Asp Lys Ala Gly Lys Ser Leu Ala Pro Val Ala Ala Asp 
65                  70                  75                  80  

Leu Ala Ala Lys Leu Gly Gln Asp Val Val Phe Pro Gly Val Thr Arg 
                85                  90                  95      

Gly Ala Glu Leu Glu Ala Ala Ile Asn Ala Leu Glu Asp Gly Gln Val 
            100                 105                 110         

Leu Leu Val Glu Asn Thr Arg Tyr Glu Asp Val Asp Gly Lys Lys Glu 
        115                 120                 125             

Ser Lys Asn Asp Pro Glu Leu Gly Lys Tyr Trp Ala Ser Leu Gly Asp 
    130                 135                 140                 

Gly Ile Phe Val Asn Asp Ala Phe Gly Thr Ala His Arg Ala His Ala 
145                 150                 155                 160 

Ser Asn Val Gly Ile Ser Ala Asn Val Glu Lys Ala Val Ala Gly Phe 
                165                 170                 175     

Leu Leu Glu Asn Glu Ile Ala Tyr Ile Gln Glu Ala Val Glu Thr Pro 
            180                 185                 190         

Glu Arg Pro Phe Val Ala Ile Leu Gly Gly Ser Lys Val Ser Asp Lys 
        195                 200                 205             

Ile Gly Val Ile Glu Asn Leu Leu Glu Lys Ala Asp Asn Val Leu Ile 
    210                 215                 220                 

Gly Gly Gly Met Thr Tyr Thr Phe Tyr Lys Ala Gln Gly Ile Glu Ile 
225                 230                 235                 240 


Gly Asn Ser Leu Val Glu Glu Asp Lys Leu Asp Val Ala Lys Ala Leu 
                245                 250                 255     

Leu Glu Lys Ala Asn Gly Lys Leu Ile Leu Pro Val Asp Ser Lys Glu 
            260                 265                 270         

Ala Asn Ala Phe Ala Gly Tyr Thr Glu Val Arg Asp Thr Glu Gly Glu 
        275                 280                 285             

Ala Val Ser Glu Gly Phe Leu Gly Leu Asp Ile Gly Pro Lys Ser Ile 
    290                 295                 300                 

Ala Lys Phe Asp Glu Ala Leu Thr Gly Ala Lys Thr Val Val Trp Asn 
305                 310                 315                 320 

Gly Pro Met Gly Val Phe Glu Asn Pro Asp Phe Gln Ala Gly Thr Ile 
                325                 330                 335     

Gly Val Met Asp Ala Ile Val Lys Gln Pro Gly Val Lys Ser Ile Ile 
            340                 345                 350         

Gly Gly Gly Asp Ser Ala Ala Ala Ala Ile Asn Leu Gly Arg Ala Asp 
        355                 360                 365             

Lys Phe Ser Trp Ile Ser Thr Gly Gly Gly Ala Ser Met Glu Leu Leu 
    370                 375                 380                 

Glu Gly Lys Val Leu Pro Gly Leu Ala Ala Leu Thr Glu Lys 
385                 390                 395             

<210>   861
<211>   525
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   861
atgagttatt ttaaaaaata taaattcgat aaatcccagt tcaaacttgg tatgcgaacc   60
tttaaaacag gtattgctgt ttttctagtt ctcttgattt ttggcttttt tggctggaaa   120
ggtcttcaaa ttggtgcttt gacagccgtt tttagcctga gggagagttt tgatgagagt   180
gttcattttg ggacttcgcg tattctagga aatagtatcg gtggactcta tgccttggtc   240
ttcttcttat taaatacctt tttccacgaa gccttttggg tgaccttggt agttgttcca   300
atctgcacca tgttaaccat tatgacaaat gtagccatga ataacaaagc aggggttatt   360
ggtggtgtag cagctatgtt aatcattacc ctatcaattc caagtggtga gacaattttg   420
tacgtgtttg tgcgtgtatt agaaacgttt atgggagttt ttgtcgcaat tatcgtaaat   480
tacgatattg atcgtattcg tctcttttta gagaaaaaag aaaaa                   525

<210>   862
<211>   175
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902486 (1.E-96)

<400>   862
Met Ser Tyr Phe Lys Lys Tyr Lys Phe Asp Lys Ser Gln Phe Lys Leu 
1               5                   10                  15      

Gly Met Arg Thr Phe Lys Thr Gly Ile Ala Val Phe Leu Val Leu Leu 
            20                  25                  30          

Ile Phe Gly Phe Phe Gly Trp Lys Gly Leu Gln Ile Gly Ala Leu Thr 
        35                  40                  45              

Ala Val Phe Ser Leu Arg Glu Ser Phe Asp Glu Ser Val His Phe Gly 
    50                  55                  60                  

Thr Ser Arg Ile Leu Gly Asn Ser Ile Gly Gly Leu Tyr Ala Leu Val 
65                  70                  75                  80  

Phe Phe Leu Leu Asn Thr Phe Phe His Glu Ala Phe Trp Val Thr Leu 
                85                  90                  95      

Val Val Val Pro Ile Cys Thr Met Leu Thr Ile Met Thr Asn Val Ala 
            100                 105                 110         

Met Asn Asn Lys Ala Gly Val Ile Gly Gly Val Ala Ala Met Leu Ile 
        115                 120                 125             

Ile Thr Leu Ser Ile Pro Ser Gly Glu Thr Ile Leu Tyr Val Phe Val 
    130                 135                 140                 

Arg Val Leu Glu Thr Phe Met Gly Val Phe Val Ala Ile Ile Val Asn 
145                 150                 155                 160 

Tyr Asp Ile Asp Arg Ile Arg Leu Phe Leu Glu Lys Lys Glu Lys 
                165                 170                 175 

<210>   863
<211>   354
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   863
atgaaggaaa aagaatttcg ccgaaatatg gctgtttttc ctatcggcag tgttatgaag   60
ttgaccgatc tatcggcgcg tcagattcgt tattatgaag atcaagagtt gatcaagccc   120
gatcgaaacg aaggaaatcg tcgcatgtat tccttgaatg acatggatcg tctgcttgaa   180
atcaaagatt atatctctga aggttataat atcgctgcca ttaagaaaaa atatgctgaa   240
cgtgaagcga aatccaagaa agcggttagt cagactgaag tacgtcgtgc acttcacaat   300
gaactcctcc aacaggggcg ttttgcttca gtacagtcac cttttggtcg cggt         354

<210>   864
<211>   118
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, MerR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902487 (2.E-63)

<400>   864
Met Lys Glu Lys Glu Phe Arg Arg Asn Met Ala Val Phe Pro Ile Gly 
1               5                   10                  15      

Ser Val Met Lys Leu Thr Asp Leu Ser Ala Arg Gln Ile Arg Tyr Tyr 
            20                  25                  30          

Glu Asp Gln Glu Leu Ile Lys Pro Asp Arg Asn Glu Gly Asn Arg Arg 
        35                  40                  45              

Met Tyr Ser Leu Asn Asp Met Asp Arg Leu Leu Glu Ile Lys Asp Tyr 
    50                  55                  60                  

Ile Ser Glu Gly Tyr Asn Ile Ala Ala Ile Lys Lys Lys Tyr Ala Glu 
65                  70                  75                  80  

Arg Glu Ala Lys Ser Lys Lys Ala Val Ser Gln Thr Glu Val Arg Arg 
                85                  90                  95      

Ala Leu His Asn Glu Leu Leu Gln Gln Gly Arg Phe Ala Ser Val Gln 
            100                 105                 110         

Ser Pro Phe Gly Arg Gly 
        115             

<210>   865
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   865
atgccaatca cagctgcaga tattcgtcgt gaagtcaagg aaaaaaatgt tacctttatt   60
cgtcttatgt tctcagatat tttgggaacc atgaaaaacg tcgaaattcc tgctacagat   120
gaacagttag ataaggtctt gtcgaacaag gttatgtttg atggatcttc tattgaaggt   180
tttgtacgta tcaatgagtc ggatatgtac ttgtacccgg acttggatac atggacagtc   240
ttcccttggg gagatgaaaa tggaagtgtt gcaggtctga tctgtgatgt ctatacaaca   300
gaaggtgaac catttgcggg tgaccctcgt ggtaatttga aacgagctct tcgtcacatg   360
gaagaagttg gattcaaatc cttcaacctt ggtccagagc cagaattctt cctatttaag   420
ttggatgaaa atggggaccc aacacttgaa gtgaatgaca agggtggcta ctttgacttg   480
gcacctactg accttgcgga caacacacgt cgtgagattg tgaatgtctt gaccaaaatg   540
ggatttgaag tagaagcgag tcaccacgag gttgcggttg gacagcatga gattgacttt   600
aagtacgatg aagttctccg tgcttgtgat aagattcaaa tctttaagct tgttgttaaa   660
accattgctc gcaaacacgg actttacgca acatttatgg cgaagccaaa atttggtatt   720
gctggatcag gtatgcactg taatatgtcc ttgtttgatg cagaaggaaa taacgccttc   780
tttgatccaa atgatccaaa aggaatgcag ttgtcagaaa cagcttacca tttcctaggc   840
ggtttgatca agcatgctta caactatact gccatcatga acccaacagt taactcatac   900
aaacgtttgg ttccaggtta tgaagcgcct gtttacattg cttgggctgg tcgtaaccgt   960
tcgccacttg tgcgcgtacc tgcttcacgt ggtatgggaa ctcgtcttga gttgcgttca   1020
gtggatccaa tggcgaaccc ttacgttgct atggctgttc ttttggaagt tggtttgtat   1080
ggtattgaaa ataaaatcga agcaccagct cctatcgaag aaaatatcta catcatgaca   1140
gcagaagagc gcaaggaagc tggtattaca gaccttccat caactcttca caacgctttg   1200
aaagctttga cagaagatga agtggttaaa gctgctctcg gagatcacat ctatactagc   1260
ttccttgaag ccaaacgaat cgaatgggca agttatgcaa ccttcgtttc acaatgggaa   1320
attgataatt atttagacct ttac                                          1344

<210>   866
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamine synthetase, type 1 (glnA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902488 (0.E+01)

<400>   866
Met Pro Ile Thr Ala Ala Asp Ile Arg Arg Glu Val Lys Glu Lys Asn 
1               5                   10                  15      

Val Thr Phe Ile Arg Leu Met Phe Ser Asp Ile Leu Gly Thr Met Lys 
            20                  25                  30          

Asn Val Glu Ile Pro Ala Thr Asp Glu Gln Leu Asp Lys Val Leu Ser 
        35                  40                  45              

Asn Lys Val Met Phe Asp Gly Ser Ser Ile Glu Gly Phe Val Arg Ile 
    50                  55                  60                  

Asn Glu Ser Asp Met Tyr Leu Tyr Pro Asp Leu Asp Thr Trp Thr Val 
65                  70                  75                  80  

Phe Pro Trp Gly Asp Glu Asn Gly Ser Val Ala Gly Leu Ile Cys Asp 
                85                  90                  95      

Val Tyr Thr Thr Glu Gly Glu Pro Phe Ala Gly Asp Pro Arg Gly Asn 
            100                 105                 110         

Leu Lys Arg Ala Leu Arg His Met Glu Glu Val Gly Phe Lys Ser Phe 
        115                 120                 125             

Asn Leu Gly Pro Glu Pro Glu Phe Phe Leu Phe Lys Leu Asp Glu Asn 
    130                 135                 140                 

Gly Asp Pro Thr Leu Glu Val Asn Asp Lys Gly Gly Tyr Phe Asp Leu 
145                 150                 155                 160 

Ala Pro Thr Asp Leu Ala Asp Asn Thr Arg Arg Glu Ile Val Asn Val 
                165                 170                 175     

Leu Thr Lys Met Gly Phe Glu Val Glu Ala Ser His His Glu Val Ala 
            180                 185                 190         

Val Gly Gln His Glu Ile Asp Phe Lys Tyr Asp Glu Val Leu Arg Ala 
        195                 200                 205             

Cys Asp Lys Ile Gln Ile Phe Lys Leu Val Val Lys Thr Ile Ala Arg 
    210                 215                 220                 

Lys His Gly Leu Tyr Ala Thr Phe Met Ala Lys Pro Lys Phe Gly Ile 
225                 230                 235                 240 

Ala Gly Ser Gly Met His Cys Asn Met Ser Leu Phe Asp Ala Glu Gly 
                245                 250                 255     

Asn Asn Ala Phe Phe Asp Pro Asn Asp Pro Lys Gly Met Gln Leu Ser 
            260                 265                 270         

Glu Thr Ala Tyr His Phe Leu Gly Gly Leu Ile Lys His Ala Tyr Asn 
        275                 280                 285             

Tyr Thr Ala Ile Met Asn Pro Thr Val Asn Ser Tyr Lys Arg Leu Val 
    290                 295                 300                 

Pro Gly Tyr Glu Ala Pro Val Tyr Ile Ala Trp Ala Gly Arg Asn Arg 
305                 310                 315                 320 

Ser Pro Leu Val Arg Val Pro Ala Ser Arg Gly Met Gly Thr Arg Leu 
                325                 330                 335     

Glu Leu Arg Ser Val Asp Pro Met Ala Asn Pro Tyr Val Ala Met Ala 
            340                 345                 350         

Val Leu Leu Glu Val Gly Leu Tyr Gly Ile Glu Asn Lys Ile Glu Ala 
        355                 360                 365             

Pro Ala Pro Ile Glu Glu Asn Ile Tyr Ile Met Thr Ala Glu Glu Arg 
    370                 375                 380                 

Lys Glu Ala Gly Ile Thr Asp Leu Pro Ser Thr Leu His Asn Ala Leu 
385                 390                 395                 400 

Lys Ala Leu Thr Glu Asp Glu Val Val Lys Ala Ala Leu Gly Asp His 
                405                 410                 415     

Ile Tyr Thr Ser Phe Leu Glu Ala Lys Arg Ile Glu Trp Ala Ser Tyr 
            420                 425                 430         

Ala Thr Phe Val Ser Gln Trp Glu Ile Asp Asn Tyr Leu Asp Leu Tyr 
        435                 440                 445             


<210>   867
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   867
ttgcccgata ttgtttttga aattgaattt ttccatagtg actccttaat tttcttctac   60
acgtctgatg ataaatctaa ttcgcaaaag agtcaagagg atttttcgaa aaataaa      117

<210>   868
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   868
Met Pro Asp Ile Val Phe Glu Ile Glu Phe Phe His Ser Asp Ser Leu 
1               5                   10                  15      

Ile Phe Phe Tyr Thr Ser Asp Asp Lys Ser Asn Ser Gln Lys Ser Gln 
            20                  25                  30          

Glu Asp Phe Ser Lys Asn Lys 
        35                  

<210>   869
<211>   135
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   869
ttgaatcctg atcgagcgga agaatatttc tgccgaggtt gccaagggga aaatcctgaa   60
gatattgaat tttatgatga acaattacag gcagaaaagg tggaggattt gaatattcga   120
ttggaagtaa aaaat                                                    135

<210>   870
<211>   45
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   870
Met Asn Pro Asp Arg Ala Glu Glu Tyr Phe Cys Arg Gly Cys Gln Gly 
1               5                   10                  15      

Glu Asn Pro Glu Asp Ile Glu Phe Tyr Asp Glu Gln Leu Gln Ala Glu 
            20                  25                  30          

Lys Val Glu Asp Leu Asn Ile Arg Leu Glu Val Lys Asn 
        35                  40                  45  

<210>   871
<211>   1278
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   871
gtgaggataa aatcaattta ttggaatttt gggcaaaata agccagagaa atcctttagg   60
tatatagata cgtctagtat tgatagaaaa aagaacataa tcaactacaa aaatctacaa   120
tatctttcac ctgaacaagc gccttcccgt gctagaaaat tagtttcgca gaatagtgtc   180
ttattttcaa cagttagacc atatctaaaa aatattgctg tagttagaga acttaaagag   240
tatttgatag ctagtacagc atttattgtt ttggatactt tacttaacga aacatatttg   300
aaatattatt tattatcaga taattttatc aatcgtgtta ataataaatc tactggaaca   360
agttatcctg caatcaatga ttataatttt aatctattat taattgctct ccccccacta   420
tccgaacaac aacgaatagt agaagcaatc gaatcagctt tagaaaaagt agatgaatat   480
gctgaaagtt ataatagact agaacagcta gataaagaat ttccagataa actaaaaaaa   540
tctattcttc aatatgctat gcaaggaaaa ttagttgaac aagacccaaa tgatgaatca   600
gtcgaagttt tacttgaaaa aatacgagca gaaaaacaaa aactctttga agaaggcaag   660
attaaaaaga aagatttgga catttctatt gtttcccaag gagatgataa ctcttattat   720
gaggaagtac cttgtgaaat accagaaagt tgggaatggg tgaggttaaa cgatataacc   780
tcctacattc aaagagggaa gtctccaaaa tattcaaata ttcctatata ccctgtgatt   840
gctcagaaat gtaatcaatg gtctggcttt tctattgact tagcaagatt tattgatccc   900
gaaacagttc atagttacca gaaagaaaga ttactaagag atggtgattt aatgtggaat   960
tcaacaggtc taggtacgtt aggacgatta gctatttacc atgaaaataa aaatccttat   1020
ggctgggctg ttgcagatag ccatgttaca gttataagag tcttatcggg ggttattaat   1080
tgccatttca tctataattt tctttcctct cctattgttc agtcagttat tgaagaaaaa   1140
gcgtcgggta gtacaaaaca aaaagaatta ttaacgaaaa ctataaaaga atatttaatc   1200
cccctcccac cccttcctga acaatccaga atcgttgata aaatcgaaca atttttcgcc   1260
catattgacg cactaatt                                                 1278

<210>   872
<211>   426
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type I restriction-modification system, S subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902492 (e-171)

<400>   872
Met Arg Ile Lys Ser Ile Tyr Trp Asn Phe Gly Gln Asn Lys Pro Glu 
1               5                   10                  15      

Lys Ser Phe Arg Tyr Ile Asp Thr Ser Ser Ile Asp Arg Lys Lys Asn 
            20                  25                  30          

Ile Ile Asn Tyr Lys Asn Leu Gln Tyr Leu Ser Pro Glu Gln Ala Pro 
        35                  40                  45              

Ser Arg Ala Arg Lys Leu Val Ser Gln Asn Ser Val Leu Phe Ser Thr 
    50                  55                  60                  

Val Arg Pro Tyr Leu Lys Asn Ile Ala Val Val Arg Glu Leu Lys Glu 
65                  70                  75                  80  

Tyr Leu Ile Ala Ser Thr Ala Phe Ile Val Leu Asp Thr Leu Leu Asn 
                85                  90                  95      

Glu Thr Tyr Leu Lys Tyr Tyr Leu Leu Ser Asp Asn Phe Ile Asn Arg 
            100                 105                 110         

Val Asn Asn Lys Ser Thr Gly Thr Ser Tyr Pro Ala Ile Asn Asp Tyr 
        115                 120                 125             

Asn Phe Asn Leu Leu Leu Ile Ala Leu Pro Pro Leu Ser Glu Gln Gln 
    130                 135                 140                 

Arg Ile Val Glu Ala Ile Glu Ser Ala Leu Glu Lys Val Asp Glu Tyr 
145                 150                 155                 160 

Ala Glu Ser Tyr Asn Arg Leu Glu Gln Leu Asp Lys Glu Phe Pro Asp 
                165                 170                 175     

Lys Leu Lys Lys Ser Ile Leu Gln Tyr Ala Met Gln Gly Lys Leu Val 
            180                 185                 190         

Glu Gln Asp Pro Asn Asp Glu Ser Val Glu Val Leu Leu Glu Lys Ile 
        195                 200                 205             

Arg Ala Glu Lys Gln Lys Leu Phe Glu Glu Gly Lys Ile Lys Lys Lys 
    210                 215                 220                 

Asp Leu Asp Ile Ser Ile Val Ser Gln Gly Asp Asp Asn Ser Tyr Tyr 
225                 230                 235                 240 


Glu Glu Val Pro Cys Glu Ile Pro Glu Ser Trp Glu Trp Val Arg Leu 
                245                 250                 255     

Asn Asp Ile Thr Ser Tyr Ile Gln Arg Gly Lys Ser Pro Lys Tyr Ser 
            260                 265                 270         

Asn Ile Pro Ile Tyr Pro Val Ile Ala Gln Lys Cys Asn Gln Trp Ser 
        275                 280                 285             

Gly Phe Ser Ile Asp Leu Ala Arg Phe Ile Asp Pro Glu Thr Val His 
    290                 295                 300                 

Ser Tyr Gln Lys Glu Arg Leu Leu Arg Asp Gly Asp Leu Met Trp Asn 
305                 310                 315                 320 

Ser Thr Gly Leu Gly Thr Leu Gly Arg Leu Ala Ile Tyr His Glu Asn 
                325                 330                 335     

Lys Asn Pro Tyr Gly Trp Ala Val Ala Asp Ser His Val Thr Val Ile 
            340                 345                 350         

Arg Val Leu Ser Gly Val Ile Asn Cys His Phe Ile Tyr Asn Phe Leu 
        355                 360                 365             

Ser Ser Pro Ile Val Gln Ser Val Ile Glu Glu Lys Ala Ser Gly Ser 
    370                 375                 380                 

Thr Lys Gln Lys Glu Leu Leu Thr Lys Thr Ile Lys Glu Tyr Leu Ile 
385                 390                 395                 400 

Pro Leu Pro Pro Leu Pro Glu Gln Ser Arg Ile Val Asp Lys Ile Glu 
                405                 410                 415     

Gln Phe Phe Ala His Ile Asp Ala Leu Ile 
            420                 425     

<210>   873
<211>   795
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   873
ttgaaagatt ttgaattaca tttgaagaaa gctggtttag ctgaaaatac tgtgcgttcg   60
tacctttatg gtgttcgatt tttcttggag aattacgaac tcaaaatgga agatttattt   120
gaatacaaag gatatttatt agacaatttt aaacctaaaa ctgtcaattt gcgactacaa   180
ggagtaaata aatatctggc ttttattggt catgatgatt tgaaattaaa atttgtcaaa   240
gtacagcaaa aaccgttttt agaagatgtc attagccatg ctgattacct ttttcttaaa   300
cgtagtttga aaaaagatgg tattttaaaa tggcattttg tcgtttggtt tttaggtgca   360
actggggctc gtgtaagtga acttattaaa ctaaaagtag agcatgtaga aatcggttat   420
tttgacattt actcaaaagg tggtaaaatt cgtagactgt acattcctaa aaaattaaga   480
aatagttgtc ttagttggtt agaatcagaa aatcgccgaa gtggttattt atttttgaat   540

aaatttaacg aaccaattac agcaagagga gttgctcaac agttaaaaaa ttatgctgat   600
aaatacaaaa tgaatcctaa agtaatttac cctcattctt ttaggcattt atttgctaag   660
aattttttag cgaagtataa tgatattgcc ttgcttgcag atttgatggg acacgaaagt   720
atagaaacta ctcgaattta tctaaggaaa acagctactg aacaacaaaa tattgtagat   780
aaaattgtta attgg                                                    795

<210>   874
<211>   265
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   integrase/recombinase, phage integrase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902491 (e-154)

<400>   874
Met Lys Asp Phe Glu Leu His Leu Lys Lys Ala Gly Leu Ala Glu Asn 
1               5                   10                  15      

Thr Val Arg Ser Tyr Leu Tyr Gly Val Arg Phe Phe Leu Glu Asn Tyr 
            20                  25                  30          

Glu Leu Lys Met Glu Asp Leu Phe Glu Tyr Lys Gly Tyr Leu Leu Asp 
        35                  40                  45              

Asn Phe Lys Pro Lys Thr Val Asn Leu Arg Leu Gln Gly Val Asn Lys 
    50                  55                  60                  

Tyr Leu Ala Phe Ile Gly His Asp Asp Leu Lys Leu Lys Phe Val Lys 
65                  70                  75                  80  

Val Gln Gln Lys Pro Phe Leu Glu Asp Val Ile Ser His Ala Asp Tyr 
                85                  90                  95      

Leu Phe Leu Lys Arg Ser Leu Lys Lys Asp Gly Ile Leu Lys Trp His 
            100                 105                 110         

Phe Val Val Trp Phe Leu Gly Ala Thr Gly Ala Arg Val Ser Glu Leu 
        115                 120                 125             

Ile Lys Leu Lys Val Glu His Val Glu Ile Gly Tyr Phe Asp Ile Tyr 
    130                 135                 140                 

Ser Lys Gly Gly Lys Ile Arg Arg Leu Tyr Ile Pro Lys Lys Leu Arg 
145                 150                 155                 160 

Asn Ser Cys Leu Ser Trp Leu Glu Ser Glu Asn Arg Arg Ser Gly Tyr 
                165                 170                 175     

Leu Phe Leu Asn Lys Phe Asn Glu Pro Ile Thr Ala Arg Gly Val Ala 
            180                 185                 190         

Gln Gln Leu Lys Asn Tyr Ala Asp Lys Tyr Lys Met Asn Pro Lys Val 
        195                 200                 205             

Ile Tyr Pro His Ser Phe Arg His Leu Phe Ala Lys Asn Phe Leu Ala 
    210                 215                 220                 

Lys Tyr Asn Asp Ile Ala Leu Leu Ala Asp Leu Met Gly His Glu Ser 
225                 230                 235                 240 

Ile Glu Thr Thr Arg Ile Tyr Leu Arg Lys Thr Ala Thr Glu Gln Gln 
                245                 250                 255     

Asn Ile Val Asp Lys Ile Val Asn Trp 
            260                 265 

<210>   875
<211>   597
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   875
gtggtcaaac tgactacctg ctatttttgt gattatggct cttattatgg gaatatacct   60
atgaattggg ttgttataaa aataaaagat attttttcaa taaatacagg tctttcttac   120
aagaagggcg atttaagcat taataataaa ggtgttagaa ttatacgtgg tggtaatatt   180
aagcctttag aattttctct gttggataat gattactaca ttgatacaca attcatctcc   240
tctgagcaag tttatttaaa acataatcag ctaataacac ctgtatcaac ctctttagaa   300
catattggaa agtttgcaag aatcgataaa gactatgatg gtgttgtggc tggtggattt   360
attttccaat taacaccatt cgaaagttca gagattattt caaaatttct attatttaac   420
ttgtcctctc cgttatttta taaacaattg aaagcaataa ctaaactatc aggtcaagct   480
ttatataata ttcctaaaac tacactgagc gagctattaa ttccgttagc tccttttgag   540
gaacaggaac ttattactca aaaagttgag aaactttttg aaaaagtaaa tcaactt      597

<210>   876
<211>   199
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type I restriction-modification system, S subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902490 (3.E-98)

<400>   876
Met Val Lys Leu Thr Thr Cys Tyr Phe Cys Asp Tyr Gly Ser Tyr Tyr 
1               5                   10                  15      

Gly Asn Ile Pro Met Asn Trp Val Val Ile Lys Ile Lys Asp Ile Phe 
            20                  25                  30          

Ser Ile Asn Thr Gly Leu Ser Tyr Lys Lys Gly Asp Leu Ser Ile Asn 
        35                  40                  45              

Asn Lys Gly Val Arg Ile Ile Arg Gly Gly Asn Ile Lys Pro Leu Glu 
    50                  55                  60                  

Phe Ser Leu Leu Asp Asn Asp Tyr Tyr Ile Asp Thr Gln Phe Ile Ser 
65                  70                  75                  80  

Ser Glu Gln Val Tyr Leu Lys His Asn Gln Leu Ile Thr Pro Val Ser 
                85                  90                  95      

Thr Ser Leu Glu His Ile Gly Lys Phe Ala Arg Ile Asp Lys Asp Tyr 
            100                 105                 110         

Asp Gly Val Val Ala Gly Gly Phe Ile Phe Gln Leu Thr Pro Phe Glu 
        115                 120                 125             

Ser Ser Glu Ile Ile Ser Lys Phe Leu Leu Phe Asn Leu Ser Ser Pro 

    130                 135                 140                 

Leu Phe Tyr Lys Gln Leu Lys Ala Ile Thr Lys Leu Ser Gly Gln Ala 
145                 150                 155                 160 

Leu Tyr Asn Ile Pro Lys Thr Thr Leu Ser Glu Leu Leu Ile Pro Leu 
                165                 170                 175     

Ala Pro Phe Glu Glu Gln Glu Leu Ile Thr Gln Lys Val Glu Lys Leu 
            180                 185                 190         

Phe Glu Lys Val Asn Gln Leu 
        195                 

<210>   877
<211>   1566
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   877
atgacaccag aacaacttaa agcaagtatt ctccaaagag cgatggaagg gaaattagtg   60
ccgcaaaatc ccaatgacga acctgcaagt gaattattaa agagaattaa agctgaaaaa   120
gaaaaactta tcagtgaagg aaaaatcaaa cgagataaaa aggaaactga gatatttcgt   180
ggtgatgatg ggaaacatta tgggaagttt gctgatggaa gcactcaaga aattgatgtt   240
ccttatgata ttcctgatac ttgggagtgg gtgaggtttt ctacattggt tgaaattgtc   300
agaggtggct ctccacgacc aatcaaagat tatcttactt ctgaagtaga tggaataaat   360
tggataaaaa taggtgatac tgaaaagggt gaaaagtata taaataatgt taaagaaaaa   420
atcaaaaaat cagggcttaa caaaactaga tttgtaaaaa aaggtacatt tttgttaact   480
aattctatga gttttggtag accttatatt ttgaatgttg atggtgcaat acacgatgga   540
tggttggcta tttcgaacta tgaaaactca ttaaataaag attacctatt ctatattctt   600
tcatcaaatg tagtttattc tcaatttcta tctctaatta gtggagctgt tgtgaaaaac   660
ttgaatagtg ataaagttgc ttctattctt atccctctcc ccccactatc cgaacaacaa   720
cgaatagtag aagcaatcga atcagcttta gaaaaagtag atgaatatgc tgaaagttat   780
aatagactag aacagctaga taaagaattt ccagataaac taaaaaaatc tattcttcaa   840
tatgctatgc aaggaaaatt agttgaacaa gacccaaatg atgaatcagt cgaagtttta   900
cttgaaaaaa tacgagcaga aaaacaaaaa ctctttgaag aaggcaagat taaaaagaaa   960
gatttggaca tttctattgt ttcccaagga gatgataact cttattatgg gaacaaagac   1020
gaaacaacct cttatcctat atatgaaatc ccagaagcat ggagatatat taaatttgct   1080
agcctagtta acttcagaat aggaaaaact cctccacgca gtgaagctac tttttgggga   1140
actgaaatac cttgggtatc tatatcagat atgcctatat ctggttatgt aactaatgcg   1200
agagaatcta tttctaaatt agcattaaaa tcaaagaaaa tagacatttc acctaaagga   1260
actttattaa tgagttttaa attatctatt ggaaaagttg ccatattgga tattcctgcc   1320
actcataatg aagccattat atcgatattc ccctatgcta ataaagaaaa tattatcaga   1380
gattacttaa tgatattttt gccacttatc tctactttag gtgattcaaa agatgctatc   1440
aaagggaaaa cattaaatag taccagtatc tccgaattat taatccctat ttctaatcat   1500
gaagagatga aaagaatcat tttcaaagtt gatttacttt ttcaaaaagt ttctcaactt   1560
tttgag                                                              1566

<210>   878
<211>   522
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type I restriction-modification system, S subunit (hsdS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902492 (0.E+01)

<400>   878
Met Thr Pro Glu Gln Leu Lys Ala Ser Ile Leu Gln Arg Ala Met Glu 
1               5                   10                  15      

Gly Lys Leu Val Pro Gln Asn Pro Asn Asp Glu Pro Ala Ser Glu Leu 
            20                  25                  30          

Leu Lys Arg Ile Lys Ala Glu Lys Glu Lys Leu Ile Ser Glu Gly Lys 
        35                  40                  45              

Ile Lys Arg Asp Lys Lys Glu Thr Glu Ile Phe Arg Gly Asp Asp Gly 
    50                  55                  60                  

Lys His Tyr Gly Lys Phe Ala Asp Gly Ser Thr Gln Glu Ile Asp Val 
65                  70                  75                  80  

Pro Tyr Asp Ile Pro Asp Thr Trp Glu Trp Val Arg Phe Ser Thr Leu 
                85                  90                  95      

Val Glu Ile Val Arg Gly Gly Ser Pro Arg Pro Ile Lys Asp Tyr Leu 
            100                 105                 110         

Thr Ser Glu Val Asp Gly Ile Asn Trp Ile Lys Ile Gly Asp Thr Glu 
        115                 120                 125             

Lys Gly Glu Lys Tyr Ile Asn Asn Val Lys Glu Lys Ile Lys Lys Ser 
    130                 135                 140                 

Gly Leu Asn Lys Thr Arg Phe Val Lys Lys Gly Thr Phe Leu Leu Thr 
145                 150                 155                 160 

Asn Ser Met Ser Phe Gly Arg Pro Tyr Ile Leu Asn Val Asp Gly Ala 
                165                 170                 175     

Ile His Asp Gly Trp Leu Ala Ile Ser Asn Tyr Glu Asn Ser Leu Asn 
            180                 185                 190         

Lys Asp Tyr Leu Phe Tyr Ile Leu Ser Ser Asn Val Val Tyr Ser Gln 
        195                 200                 205             

Phe Leu Ser Leu Ile Ser Gly Ala Val Val Lys Asn Leu Asn Ser Asp 
    210                 215                 220                 

Lys Val Ala Ser Ile Leu Ile Pro Leu Pro Pro Leu Ser Glu Gln Gln 
225                 230                 235                 240 

Arg Ile Val Glu Ala Ile Glu Ser Ala Leu Glu Lys Val Asp Glu Tyr 
                245                 250                 255     

Ala Glu Ser Tyr Asn Arg Leu Glu Gln Leu Asp Lys Glu Phe Pro Asp 
            260                 265                 270         

Lys Leu Lys Lys Ser Ile Leu Gln Tyr Ala Met Gln Gly Lys Leu Val 
        275                 280                 285             

Glu Gln Asp Pro Asn Asp Glu Ser Val Glu Val Leu Leu Glu Lys Ile 
    290                 295                 300                 

Arg Ala Glu Lys Gln Lys Leu Phe Glu Glu Gly Lys Ile Lys Lys Lys 
305                 310                 315                 320 

Asp Leu Asp Ile Ser Ile Val Ser Gln Gly Asp Asp Asn Ser Tyr Tyr 
                325                 330                 335     

Gly Asn Lys Asp Glu Thr Thr Ser Tyr Pro Ile Tyr Glu Ile Pro Glu 
            340                 345                 350         

Ala Trp Arg Tyr Ile Lys Phe Ala Ser Leu Val Asn Phe Arg Ile Gly 
        355                 360                 365             

Lys Thr Pro Pro Arg Ser Glu Ala Thr Phe Trp Gly Thr Glu Ile Pro 
    370                 375                 380                 

Trp Val Ser Ile Ser Asp Met Pro Ile Ser Gly Tyr Val Thr Asn Ala 
385                 390                 395                 400 

Arg Glu Ser Ile Ser Lys Leu Ala Leu Lys Ser Lys Lys Ile Asp Ile 
                405                 410                 415     

Ser Pro Lys Gly Thr Leu Leu Met Ser Phe Lys Leu Ser Ile Gly Lys 
            420                 425                 430         

Val Ala Ile Leu Asp Ile Pro Ala Thr His Asn Glu Ala Ile Ile Ser 
        435                 440                 445             

Ile Phe Pro Tyr Ala Asn Lys Glu Asn Ile Ile Arg Asp Tyr Leu Met 
    450                 455                 460                 

Ile Phe Leu Pro Leu Ile Ser Thr Leu Gly Asp Ser Lys Asp Ala Ile 
465                 470                 475                 480 

Lys Gly Lys Thr Leu Asn Ser Thr Ser Ile Ser Glu Leu Leu Ile Pro 
                485                 490                 495     

Ile Ser Asn His Glu Glu Met Lys Arg Ile Ile Phe Lys Val Asp Leu 
            500                 505                 510         

Leu Phe Gln Lys Val Ser Gln Leu Phe Glu 
        515                 520         

<210>   879
<211>   1461

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   879
atgtcaatta catcatttgt aaaaagaatt caagatatca ctcgaaacga tgctggtgtt   60
aatggtgatg ctcaacgtat tgagcaaatg tcttggttat tattcttaaa aatttatgat   120
agccgtgaaa tggtttggga attagaagaa gacgagtatg agtcaattat cccagaggaa   180
ttaaaatggc gaaattgggc tcatgctcaa aatggggaac gggtattgac aggcgatgaa   240
ttacttgatt ttgtcaataa caagttattc aaagagttga aagagcttga aataacttca   300
aatatgccta ttcgaaaaac gattgttaaa tcagcttttg aagatgcgaa caactatatg   360
aaaaatggcg tcttgttacg ccaagtcatc aatgttattg atgaagttga tttcaatagc   420
cctgaagatc gtcattcgtt taatgatatt tacgaaaaaa ttcttaaaga tattcaaaat   480
gctgggaact caggagaatt ttatacgcca cgtgcagcga ctgattttat tgccgaagtt   540
cttgacccaa aacttggaga atcaatggca gaccttgctt gcggaacagg aggcttcttg   600
acttcgactc tgaaccgttt aagtagtcaa cgtaaaacta gtgaagatac caaaaaatat   660
aatacagctg tttttggtat tgaaaagaaa gcatttcctc atcttttagc agttacaaat   720
ctgtttcttc acgaaattga tgaccctaaa attgttcatg gaaatacttt ggagaaaaat   780
gttcgtgaat atacggatga tgaaaaattt gacattatta tgatgaatcc accttttgga   840
gggtcagaat tagaaacaat aaaaaataac tttccagcag aattacggag ttctgaaaca   900
gctgatttat ttatggctgt cattatgtat cgtttgaaag aaaatggtcg tgttggagtt   960
attttacctg atggttttct atttggtgaa ggtgtaaaaa ctcgcttgaa acaaaaactg   1020
gtagatgagt tcaacttgca tacgattatt aggttgcctc atagtgtctt tgcaccgtat   1080
acaggaatcc atacgaacat tcttttcttt gataaaacaa agaaaacaga agaaacttgg   1140
ttttatcgtt tagatatgcc agatggttat aaaaatttct cgaaaactaa gccgatgaag   1200
tcagaacact tcaatcctgt tcgtgactgg tgggaaaatc gtgaagagat tctggaaggt   1260
aagttctaca aatctaaatc atttacacct agtgaattgg ctgagttgaa ttataattta   1320
gaccagtgtg actttccaaa agaggaagag gaaatcttaa atccctttga gttgattcag   1380
aattatcaag cggaaagagc aactttaaat cataagattg ataatgtatt agctgatatt   1440
ttgcagttgt tggaggacaa a                                             1461

<210>   880
<211>   487
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type I restriction-modification system, M subunit (hsdM)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902493 (0.E+01)

<400>   880
Met Ser Ile Thr Ser Phe Val Lys Arg Ile Gln Asp Ile Thr Arg Asn 
1               5                   10                  15      

Asp Ala Gly Val Asn Gly Asp Ala Gln Arg Ile Glu Gln Met Ser Trp 
            20                  25                  30          

Leu Leu Phe Leu Lys Ile Tyr Asp Ser Arg Glu Met Val Trp Glu Leu 
        35                  40                  45              

Glu Glu Asp Glu Tyr Glu Ser Ile Ile Pro Glu Glu Leu Lys Trp Arg 
    50                  55                  60                  

Asn Trp Ala His Ala Gln Asn Gly Glu Arg Val Leu Thr Gly Asp Glu 
65                  70                  75                  80  

Leu Leu Asp Phe Val Asn Asn Lys Leu Phe Lys Glu Leu Lys Glu Leu 
                85                  90                  95      

Glu Ile Thr Ser Asn Met Pro Ile Arg Lys Thr Ile Val Lys Ser Ala 
            100                 105                 110         

Phe Glu Asp Ala Asn Asn Tyr Met Lys Asn Gly Val Leu Leu Arg Gln 
        115                 120                 125             

Val Ile Asn Val Ile Asp Glu Val Asp Phe Asn Ser Pro Glu Asp Arg 
    130                 135                 140                 

His Ser Phe Asn Asp Ile Tyr Glu Lys Ile Leu Lys Asp Ile Gln Asn 
145                 150                 155                 160 

Ala Gly Asn Ser Gly Glu Phe Tyr Thr Pro Arg Ala Ala Thr Asp Phe 
                165                 170                 175     

Ile Ala Glu Val Leu Asp Pro Lys Leu Gly Glu Ser Met Ala Asp Leu 
            180                 185                 190         

Ala Cys Gly Thr Gly Gly Phe Leu Thr Ser Thr Leu Asn Arg Leu Ser 
        195                 200                 205             

Ser Gln Arg Lys Thr Ser Glu Asp Thr Lys Lys Tyr Asn Thr Ala Val 
    210                 215                 220                 

Phe Gly Ile Glu Lys Lys Ala Phe Pro His Leu Leu Ala Val Thr Asn 
225                 230                 235                 240 

Leu Phe Leu His Glu Ile Asp Asp Pro Lys Ile Val His Gly Asn Thr 
                245                 250                 255     

Leu Glu Lys Asn Val Arg Glu Tyr Thr Asp Asp Glu Lys Phe Asp Ile 
            260                 265                 270         

Ile Met Met Asn Pro Pro Phe Gly Gly Ser Glu Leu Glu Thr Ile Lys 
        275                 280                 285             

Asn Asn Phe Pro Ala Glu Leu Arg Ser Ser Glu Thr Ala Asp Leu Phe 
    290                 295                 300                 

Met Ala Val Ile Met Tyr Arg Leu Lys Glu Asn Gly Arg Val Gly Val 
305                 310                 315                 320 

Ile Leu Pro Asp Gly Phe Leu Phe Gly Glu Gly Val Lys Thr Arg Leu 
                325                 330                 335     

Lys Gln Lys Leu Val Asp Glu Phe Asn Leu His Thr Ile Ile Arg Leu 
            340                 345                 350         

Pro His Ser Val Phe Ala Pro Tyr Thr Gly Ile His Thr Asn Ile Leu 
        355                 360                 365             

Phe Phe Asp Lys Thr Lys Lys Thr Glu Glu Thr Trp Phe Tyr Arg Leu 
    370                 375                 380                 

Asp Met Pro Asp Gly Tyr Lys Asn Phe Ser Lys Thr Lys Pro Met Lys 
385                 390                 395                 400 

Ser Glu His Phe Asn Pro Val Arg Asp Trp Trp Glu Asn Arg Glu Glu 
                405                 410                 415     

Ile Leu Glu Gly Lys Phe Tyr Lys Ser Lys Ser Phe Thr Pro Ser Glu 
            420                 425                 430         

Leu Ala Glu Leu Asn Tyr Asn Leu Asp Gln Cys Asp Phe Pro Lys Glu 
        435                 440                 445             

Glu Glu Glu Ile Leu Asn Pro Phe Glu Leu Ile Gln Asn Tyr Gln Ala 
    450                 455                 460                 

Glu Arg Ala Thr Leu Asn His Lys Ile Asp Asn Val Leu Ala Asp Ile 
465                 470                 475                 480 

Leu Gln Leu Leu Glu Asp Lys 
                485         

<210>   881
<211>   2331
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   881
atggttgagt ttataaagtc taagaaagaa atgagtgagg aggatattaa agcaaatttc   60
atcactcctg ctattgtatc caaaggatgg aaaaatggtg agcatatcgc ttacgaagaa   120
tacttcactg atggtcgaat tgaagttaga ggagataagg ctcgtcgtaa agaaggaaaa   180
aaatcagact attcactgta ttaccaattt ggaactcgaa ttgcaattgt tgaggcaaag   240
gataataaac acagcgttcg agcaggatta caacaagcta ttgaatatgg agagatttta   300
gatgttccat ttgtttattc ttcgaatggt gatggcttta ttgaacacga ccgtatcacg   360
agagaagaac gtgagctgga gttagacgaa ttccctactc gtgaagaatt attttctcgt   420
atgacgaagg aaaaaggatt gacgtacgaa attacagaag ctatctcaac tccatactat   480
acagacgcct tctcaatgaa aacgccacgc tattatcagc aaatagctat caaccgtact   540
attgaaacag ttgccagagg acaaaaacga gtaatgtttg tgatggcaac aggaacgggg   600
aaaacgttca tggcttttca aattattcat cgccttcgaa aagctggttt ggctaaacga   660
gttttattct tagcagatag aaacatctta gtagaccaaa cgatggctga agactttagg   720
ccattcgaaa aggtaatgac gaaaattaca ccaaaacttt tgactgctcc tgaaaaatta   780
aattcttttg aaatttatct agggctttat cagcaactaa ctggtgaaga tggaactgaa   840
acacattatc aaaaatttga caaagacttc tttgatttaa tcgtaattga tgaagcgcac   900
cgtggttcag ctaaggaaaa cagtaactgg cgtaaggtaa ttgattattt cagttctgcg   960
acacagattg ggatgaccgc tactcttaaa gaaaccaaga atgcttccaa tacggaatac   1020
tttggtgagc caatctatac ttatagttta aaacagggaa tcgaggatgg ttttttggct   1080
ccatatcgtg ttatgagggt taatttagat gtggatgtgg atggttatcg tccagaaact   1140
ggaaaagttg atgctaacgg acaattaata gaagataggt actacggcag gaaagatttt   1200
gataaaacca ttgtcattga tgatagaacg caaagagttg ccaagtttgt ttctgattat   1260
atgaagcaaa acaatgcacg atttgataaa acaattgttt tttgtgttga tattgaccat   1320
gccgagcgaa tgcgtgctgc acttgtaaaa gagaatctag acttagtcca agaagactat   1380
cgttatgtca tgcaagtaac tggtgacaac gctgaaggaa aagctcaact ggataacttt   1440
atggatgtca attctaattt tcccgctatt gtaacaacgt ctaaattatt aacgacagga   1500
gttaatgcta aaacatgtcg tttgattgtt ttagactcta atatccaatc catgactgaa   1560
tttaaacaaa ttattggtcg tggcacacgt ctttatcctc aaaaggggaa agaatttttt   1620
acgattattg attttcgaaa tgttaccaat ttgtttgctg accctgattt tgatggtgat   1680
ccagtgaagg tgctagaaac aggtgcgaaa acagtcagtg gttctacgcc cggtttcgta   1740
gatgaggaag gtgacccagt agaaaaatat atcgttacag acaagcaggt taccattctt   1800
aattctactg ttcaagtatt ggatgaaaac gggaaactga ttaccgaaag cctgaccgac   1860
tacactcgaa agaatatctt aggtagctac gccactttga acgattttat cacagtttgg   1920
catacggcag ataagaagaa gcttatctta gacgaacttt ataaaaaagg agtttatcta   1980
gatgctattc gagagtcgga gggaatatca gaacaagaaa tcgatgattt tgatttactc   2040
ctaaaacttg cctatggtca aaaagaatta accaaaacgg aacgtatcaa taaactcaaa   2100
caaagcggat atttatataa atatagtgag gaagcgcgtg ctgttttgga aattttactg   2160
aacaaataca tggataaagg tattggagaa ctcgaaagca ttgaaacatt aaaacttcca   2220
gaatttcaga tatatggtgg aaccttcaaa atcatcaata cttattttgg agataaaaaa   2280
cgatatttac aagcaattaa agaattggag caagagctat ttacagtagc t            2331

<210>   882
<211>   777
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type I restriction-modification system, R subunit (hsdR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902494 (0.E+01)

<400>   882
Met Val Glu Phe Ile Lys Ser Lys Lys Glu Met Ser Glu Glu Asp Ile 
1               5                   10                  15      

Lys Ala Asn Phe Ile Thr Pro Ala Ile Val Ser Lys Gly Trp Lys Asn 
            20                  25                  30          

Gly Glu His Ile Ala Tyr Glu Glu Tyr Phe Thr Asp Gly Arg Ile Glu 
        35                  40                  45              

Val Arg Gly Asp Lys Ala Arg Arg Lys Glu Gly Lys Lys Ser Asp Tyr 
    50                  55                  60                  

Ser Leu Tyr Tyr Gln Phe Gly Thr Arg Ile Ala Ile Val Glu Ala Lys 
65                  70                  75                  80  

Asp Asn Lys His Ser Val Arg Ala Gly Leu Gln Gln Ala Ile Glu Tyr 
                85                  90                  95      

Gly Glu Ile Leu Asp Val Pro Phe Val Tyr Ser Ser Asn Gly Asp Gly 
            100                 105                 110         

Phe Ile Glu His Asp Arg Ile Thr Arg Glu Glu Arg Glu Leu Glu Leu 
        115                 120                 125             

Asp Glu Phe Pro Thr Arg Glu Glu Leu Phe Ser Arg Met Thr Lys Glu 
    130                 135                 140                 

Lys Gly Leu Thr Tyr Glu Ile Thr Glu Ala Ile Ser Thr Pro Tyr Tyr 
145                 150                 155                 160 

Thr Asp Ala Phe Ser Met Lys Thr Pro Arg Tyr Tyr Gln Gln Ile Ala 
                165                 170                 175     

Ile Asn Arg Thr Ile Glu Thr Val Ala Arg Gly Gln Lys Arg Val Met 
            180                 185                 190         

Phe Val Met Ala Thr Gly Thr Gly Lys Thr Phe Met Ala Phe Gln Ile 
        195                 200                 205             

Ile His Arg Leu Arg Lys Ala Gly Leu Ala Lys Arg Val Leu Phe Leu 
    210                 215                 220                 

Ala Asp Arg Asn Ile Leu Val Asp Gln Thr Met Ala Glu Asp Phe Arg 
225                 230                 235                 240 

Pro Phe Glu Lys Val Met Thr Lys Ile Thr Pro Lys Leu Leu Thr Ala 
                245                 250                 255     

Pro Glu Lys Leu Asn Ser Phe Glu Ile Tyr Leu Gly Leu Tyr Gln Gln 
            260                 265                 270         

Leu Thr Gly Glu Asp Gly Thr Glu Thr His Tyr Gln Lys Phe Asp Lys 
        275                 280                 285             

Asp Phe Phe Asp Leu Ile Val Ile Asp Glu Ala His Arg Gly Ser Ala 
    290                 295                 300                 

Lys Glu Asn Ser Asn Trp Arg Lys Val Ile Asp Tyr Phe Ser Ser Ala 
305                 310                 315                 320 

Thr Gln Ile Gly Met Thr Ala Thr Leu Lys Glu Thr Lys Asn Ala Ser 
                325                 330                 335     

Asn Thr Glu Tyr Phe Gly Glu Pro Ile Tyr Thr Tyr Ser Leu Lys Gln 
            340                 345                 350         

Gly Ile Glu Asp Gly Phe Leu Ala Pro Tyr Arg Val Met Arg Val Asn 
        355                 360                 365             

Leu Asp Val Asp Val Asp Gly Tyr Arg Pro Glu Thr Gly Lys Val Asp 
    370                 375                 380                 

Ala Asn Gly Gln Leu Ile Glu Asp Arg Tyr Tyr Gly Arg Lys Asp Phe 
385                 390                 395                 400 

Asp Lys Thr Ile Val Ile Asp Asp Arg Thr Gln Arg Val Ala Lys Phe 
                405                 410                 415     

Val Ser Asp Tyr Met Lys Gln Asn Asn Ala Arg Phe Asp Lys Thr Ile 
            420                 425                 430         

Val Phe Cys Val Asp Ile Asp His Ala Glu Arg Met Arg Ala Ala Leu 
        435                 440                 445             

Val Lys Glu Asn Leu Asp Leu Val Gln Glu Asp Tyr Arg Tyr Val Met 
    450                 455                 460                 

Gln Val Thr Gly Asp Asn Ala Glu Gly Lys Ala Gln Leu Asp Asn Phe 
465                 470                 475                 480 

Met Asp Val Asn Ser Asn Phe Pro Ala Ile Val Thr Thr Ser Lys Leu 
                485                 490                 495     

Leu Thr Thr Gly Val Asn Ala Lys Thr Cys Arg Leu Ile Val Leu Asp 
            500                 505                 510         

Ser Asn Ile Gln Ser Met Thr Glu Phe Lys Gln Ile Ile Gly Arg Gly 
        515                 520                 525             

Thr Arg Leu Tyr Pro Gln Lys Gly Lys Glu Phe Phe Thr Ile Ile Asp 
    530                 535                 540                 

Phe Arg Asn Val Thr Asn Leu Phe Ala Asp Pro Asp Phe Asp Gly Asp 
545                 550                 555                 560 

Pro Val Lys Val Leu Glu Thr Gly Ala Lys Thr Val Ser Gly Ser Thr 
                565                 570                 575     

Pro Gly Phe Val Asp Glu Glu Gly Asp Pro Val Glu Lys Tyr Ile Val 
            580                 585                 590         

Thr Asp Lys Gln Val Thr Ile Leu Asn Ser Thr Val Gln Val Leu Asp 
        595                 600                 605             

Glu Asn Gly Lys Leu Ile Thr Glu Ser Leu Thr Asp Tyr Thr Arg Lys 
    610                 615                 620                 

Asn Ile Leu Gly Ser Tyr Ala Thr Leu Asn Asp Phe Ile Thr Val Trp 
625                 630                 635                 640 

His Thr Ala Asp Lys Lys Lys Leu Ile Leu Asp Glu Leu Tyr Lys Lys 
                645                 650                 655     

Gly Val Tyr Leu Asp Ala Ile Arg Glu Ser Glu Gly Ile Ser Glu Gln 
            660                 665                 670         

Glu Ile Asp Asp Phe Asp Leu Leu Leu Lys Leu Ala Tyr Gly Gln Lys 
        675                 680                 685             

Glu Leu Thr Lys Thr Glu Arg Ile Asn Lys Leu Lys Gln Ser Gly Tyr 
    690                 695                 700                 

Leu Tyr Lys Tyr Ser Glu Glu Ala Arg Ala Val Leu Glu Ile Leu Leu 
705                 710                 715                 720 

Asn Lys Tyr Met Asp Lys Gly Ile Gly Glu Leu Glu Ser Ile Glu Thr 
                725                 730                 735     

Leu Lys Leu Pro Glu Phe Gln Ile Tyr Gly Gly Thr Phe Lys Ile Ile 
            740                 745                 750         

Asn Thr Tyr Phe Gly Asp Lys Lys Arg Tyr Leu Gln Ala Ile Lys Glu 
        755                 760                 765             

Leu Glu Gln Glu Leu Phe Thr Val Ala 
    770                 775         

<210>   883
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   883
atgaaaatca aaaacacttt ccaactgaaa gaactacctc cagtgacaaa ctttgagaaa   60
aacggtagta gagctaaaaa gagaaataaa ataggaagca tccgcattgt taaaatccgt   120
ttggca                                                              126

<210>   884
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   884
Met Lys Ile Lys Asn Thr Phe Gln Leu Lys Glu Leu Pro Pro Val Thr 
1               5                   10                  15      

Asn Phe Glu Lys Asn Gly Ser Arg Ala Lys Lys Arg Asn Lys Ile Gly 
            20                  25                  30          

Ser Ile Arg Ile Val Lys Ile Arg Leu Ala 
        35                  40          

<210>   885
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   885
gtgtttttga ttttcataat agattgggtt ttattgatag tttttgcgat tcagatttct   60
tatatttttt ggagattgag tcaaaagtgg aaagaattat ctaataaa                108

<210>   886
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902495 (3.E-16)

<400>   886
Met Phe Leu Ile Phe Ile Ile Asp Trp Val Leu Leu Ile Val Phe Ala 
1               5                   10                  15      

Ile Gln Ile Ser Tyr Ile Phe Trp Arg Leu Ser Gln Lys Trp Lys Glu 
            20                  25                  30          

Leu Ser Asn Lys 
        35      

<210>   887
<211>   189
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   887
atgaatagca gagtagaatt tcggattttc accattgttg atttggacaa ggaagaagaa   60
catttacatg agatgcattt gaaaggttgg aggtatagaa cgagtcgttt tggtttgttc   120
tattttgacc aatgtcaacc agacgatgtc atctaccgta tctatgattc tagatttctt   180
aaaaaagta                                                           189

<210>   888
<211>   63
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902496 (1.E-30)

<400>   888
Met Asn Ser Arg Val Glu Phe Arg Ile Phe Thr Ile Val Asp Leu Asp 
1               5                   10                  15      

Lys Glu Glu Glu His Leu His Glu Met His Leu Lys Gly Trp Arg Tyr 
            20                  25                  30          

Arg Thr Ser Arg Phe Gly Leu Phe Tyr Phe Asp Gln Cys Gln Pro Asp 
        35                  40                  45              

Asp Val Ile Tyr Arg Ile Tyr Asp Ser Arg Phe Leu Lys Lys Val 
    50                  55                  60              

<210>   889
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   889
atgattctag atttcttaaa aaagtataag catgaactgc aagattttag agatagaggt   60
tgggaattga taggagcagg ttcttgttcg attcttcgta aatcgtcttc tgatttactt   120
ccagaggatc aagtctatat gagtaaaggg ctcaaatggg aagttatgcg atctagactt   180
cgttcctgta cagctacttt ctcaggtggt cttgttgttt gtatgagttt gtttagagag   240
gatctttcta tgtctttctt tcttattttt gttttatatg cttttctgat ttcttatcta   300
atttatggtt atttcagact aaaaaggaaa taccgagtag atgaa                   345

<210>   890
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902496 (2.E-57)

<400>   890
Met Ile Leu Asp Phe Leu Lys Lys Tyr Lys His Glu Leu Gln Asp Phe 
1               5                   10                  15      

Arg Asp Arg Gly Trp Glu Leu Ile Gly Ala Gly Ser Cys Ser Ile Leu 
            20                  25                  30          

Arg Lys Ser Ser Ser Asp Leu Leu Pro Glu Asp Gln Val Tyr Met Ser 
        35                  40                  45              

Lys Gly Leu Lys Trp Glu Val Met Arg Ser Arg Leu Arg Ser Cys Thr 
    50                  55                  60                  

Ala Thr Phe Ser Gly Gly Leu Val Val Cys Met Ser Leu Phe Arg Glu 
65                  70                  75                  80  

Asp Leu Ser Met Ser Phe Phe Leu Ile Phe Val Leu Tyr Ala Phe Leu 
                85                  90                  95      

Ile Ser Tyr Leu Ile Tyr Gly Tyr Phe Arg Leu Lys Arg Lys Tyr Arg 
            100                 105                 110         

Val Asp Glu 
        115 

<210>   891
<211>   1032
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   891
atggttacag agcgtcagca ggatatttta aatctgatta ttgacatctt taccaaaacg   60
cacgaacctg tcggatcaaa agccttgcaa gagtctatta actctagcag tgcaaccatt   120
cgtaatgaca tggcggaact agaaaaacaa gggttgcttg agaaggctca tacttcaagt   180
ggtcggatgc caagtgttgc tggttttcag tactatgtga aacactcact ggattttgac   240
cggctggctg aaaatgaggt atatgagatt gtcaaagcct ttgatcagga attcttcaaa   300
ttggaggata ttctgcaaga ggctgctaac ttactaacag acctgagtgg ctgtacggta   360
gtggcactgg atgttgagcc gagcaggcaa cgtttgacag cctttgatat cgttgttttg   420
gggcaacata cagccttggc ggtatttacc ctagacgagt cgcgaacggt tactagtcag   480
tttctgattc caaggaactt cttgcaggag gatttgctga aactgaagag catcattcag   540
gaacgtttcc tcggtcacac cgttttagat attcactaca agattcggac ggagattccg   600
cagattatcc agcgttactt tacaacaacg gataatgtca tcgatctctt tgaacacatc   660
tttaaggaaa tgttcaacga aaacattgtg atggcgggca aggtccatct cttgaatttt   720
gccaatctag cagcctatca gttctttgac caaccgcaaa aggtggcctt ggagattcgt   780
gaggggttgc gtgaggatca gatgcaaaat gttcgtgttg cagacggtca agagtcctgt   840
ttagctgacc tagcggtaat cagtagtaag ttcctcattc cttatcgggg agttggaatt   900
ctagccatta tcggtccagt taatctggat taccaacagc taatcaatca agtcaatgtg   960
gtcaaccgtg ttttgaccat gaagttgaca gatttttacc gctacctcag cagtaatcat   1020
tacgaagtac at                                                       1032

<210>   892
<211>   344
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   heat shock transcription repressor HrcA (hrcA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902497 (0.E+01)

<400>   892
Met Val Thr Glu Arg Gln Gln Asp Ile Leu Asn Leu Ile Ile Asp Ile 
1               5                   10                  15      

Phe Thr Lys Thr His Glu Pro Val Gly Ser Lys Ala Leu Gln Glu Ser 
            20                  25                  30          

Ile Asn Ser Ser Ser Ala Thr Ile Arg Asn Asp Met Ala Glu Leu Glu 
        35                  40                  45              

Lys Gln Gly Leu Leu Glu Lys Ala His Thr Ser Ser Gly Arg Met Pro 
    50                  55                  60                  

Ser Val Ala Gly Phe Gln Tyr Tyr Val Lys His Ser Leu Asp Phe Asp 
65                  70                  75                  80  

Arg Leu Ala Glu Asn Glu Val Tyr Glu Ile Val Lys Ala Phe Asp Gln 
                85                  90                  95      

Glu Phe Phe Lys Leu Glu Asp Ile Leu Gln Glu Ala Ala Asn Leu Leu 
            100                 105                 110         

Thr Asp Leu Ser Gly Cys Thr Val Val Ala Leu Asp Val Glu Pro Ser 
        115                 120                 125             

Arg Gln Arg Leu Thr Ala Phe Asp Ile Val Val Leu Gly Gln His Thr 
    130                 135                 140                 

Ala Leu Ala Val Phe Thr Leu Asp Glu Ser Arg Thr Val Thr Ser Gln 
145                 150                 155                 160 


Phe Leu Ile Pro Arg Asn Phe Leu Gln Glu Asp Leu Leu Lys Leu Lys 
                165                 170                 175     

Ser Ile Ile Gln Glu Arg Phe Leu Gly His Thr Val Leu Asp Ile His 
            180                 185                 190         

Tyr Lys Ile Arg Thr Glu Ile Pro Gln Ile Ile Gln Arg Tyr Phe Thr 
        195                 200                 205             

Thr Thr Asp Asn Val Ile Asp Leu Phe Glu His Ile Phe Lys Glu Met 
    210                 215                 220                 

Phe Asn Glu Asn Ile Val Met Ala Gly Lys Val His Leu Leu Asn Phe 
225                 230                 235                 240 

Ala Asn Leu Ala Ala Tyr Gln Phe Phe Asp Gln Pro Gln Lys Val Ala 
                245                 250                 255     

Leu Glu Ile Arg Glu Gly Leu Arg Glu Asp Gln Met Gln Asn Val Arg 
            260                 265                 270         

Val Ala Asp Gly Gln Glu Ser Cys Leu Ala Asp Leu Ala Val Ile Ser 
        275                 280                 285             

Ser Lys Phe Leu Ile Pro Tyr Arg Gly Val Gly Ile Leu Ala Ile Ile 
    290                 295                 300                 

Gly Pro Val Asn Leu Asp Tyr Gln Gln Leu Ile Asn Gln Val Asn Val 
305                 310                 315                 320 

Val Asn Arg Val Leu Thr Met Lys Leu Thr Asp Phe Tyr Arg Tyr Leu 
                325                 330                 335     

Ser Ser Asn His Tyr Glu Val His 
            340                 

<210>   893
<211>   546
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   893
ttgaaatcat taaaggaggc gaacatggcc caagatataa aaaatgaaga agtagaagaa   60
gttcaagaag aggaagttgt gaaaacagct gaagaaacaa ctcctgaaaa gtctgagttg   120
gacttggcaa atgaacgtgc agatgagttc gaaaacaaat atcttcgcgc tcatgcagaa   180
atgcaaaata tccaacgccg tgccaatgaa gaacgtcaaa acttgcaacg ttatcgtagc   240
caggacttgg caaaagcaat cttaccatct cttgacaacc ttgagcgtgc acttgcagtt   300
gaaggtttga cagatgatgt gaagaagggc ttggggatgg tgcaagaaag cttgattcac   360
gctttgaaag aagaaggaat tgaagaaatc gcagcagatg gcgaatttga ccataactac   420
catatggcca tccaaactct cccagcagac gatgaacacc cagtagatac catcgctcaa   480
gtctttcaaa aaggctacaa actccatgac cgcatcctac gcccagcaat ggtagtggtg   540
tataac                                                              546

<210>   894
<211>   182
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   heat shock protein GrpE (grpE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902498 (1.E-94)

<400>   894
Met Lys Ser Leu Lys Glu Ala Asn Met Ala Gln Asp Ile Lys Asn Glu 
1               5                   10                  15      

Glu Val Glu Glu Val Gln Glu Glu Glu Val Val Lys Thr Ala Glu Glu 
            20                  25                  30          

Thr Thr Pro Glu Lys Ser Glu Leu Asp Leu Ala Asn Glu Arg Ala Asp 
        35                  40                  45              

Glu Phe Glu Asn Lys Tyr Leu Arg Ala His Ala Glu Met Gln Asn Ile 
    50                  55                  60                  

Gln Arg Arg Ala Asn Glu Glu Arg Gln Asn Leu Gln Arg Tyr Arg Ser 
65                  70                  75                  80  

Gln Asp Leu Ala Lys Ala Ile Leu Pro Ser Leu Asp Asn Leu Glu Arg 
                85                  90                  95      

Ala Leu Ala Val Glu Gly Leu Thr Asp Asp Val Lys Lys Gly Leu Gly 
            100                 105                 110         

Met Val Gln Glu Ser Leu Ile His Ala Leu Lys Glu Glu Gly Ile Glu 
        115                 120                 125             

Glu Ile Ala Ala Asp Gly Glu Phe Asp His Asn Tyr His Met Ala Ile 
    130                 135                 140                 

Gln Thr Leu Pro Ala Asp Asp Glu His Pro Val Asp Thr Ile Ala Gln 
145                 150                 155                 160 


Val Phe Gln Lys Gly Tyr Lys Leu His Asp Arg Ile Leu Arg Pro Ala 
                165                 170                 175     

Met Val Val Val Tyr Asn 
            180         

<210>   895
<211>   1821
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   895
atgtctaaaa ttatcggtat tgacttaggt acaacaaact cagcagttgc agttcttgaa   60
ggaactgaaa gcaaaatcat cgcaaaccca gaaggaaacc gcacaactcc atctgtagtc   120
tcattcaaaa acggagaaat catcgttggt gatgctgcaa aacgtcaagc agttacaaac   180
ccagatacag ttatctctat caaatctaag atgggaactt ctgaaaaagt ttctgcaaat   240
ggaaaagaat acactccaca agaaatctca gctatgatcc ttcaatactt gaaaggctac   300
gctgaagact accttggtga gaaagtaacc aaagctgtta tcacagttcc ggcttacttc   360
aacgacgctc aacgtcaagc aacaaaagac gctggtaaaa ttgctggtct tgaagtagaa   420
cgtattgtta acgaaccaac tgcagcagct cttgcttatg gtttggacaa gactgacaaa   480
gaagaaaaaa tcttggtatt tgaccttggt ggtggtacat tcgacgtctc tatccttgaa   540
ttgggtgacg gtgtcttcga cgtattgtca actgcagggg acaacaaact tggtggtgac   600
gactttgacc aaaaaatcat tgaccacttg gtagcagaat tcaagaaaga aaacggtatc   660
gacttgtcta ctgacaagat ggcaatgcaa cgtttgaaag atgcggctga aaaagcgaag   720
aaagaccttt ctggtgtaac ttcaacacaa atcagcttgc catttatcac tgcaggtgag   780
gctggacctc ttcacttgga aatgactttg actcgtgcga aatttgacga tttgactcgt   840
gaccttgttg aacgtacaaa agttccagtt cgtcaagccc tttcagatgc aggtttgagc   900
ttgtcagaaa tcgacgaagt tatccttgtt ggtggttcaa ctcgtatccc tgccgttgtt   960
gaagctgtta aagctgaaac tggtaaagaa ccaaacaaat cagtaaaccc tgatgaagta   1020
gttgctatgg gtgcggctat ccaaggtggt gtgattactg gtgatgtcaa ggacgttgtc   1080
cttcttgatg taacgccatt gtcacttggt atcgaaacaa tgggtggagt atttacaaaa   1140
cttatcgatc gcaacactac aatcccaaca tctaaatcac aagtcttctc aacagcagca   1200
gacaaccaac cagccgttga tatccacgtt cttcaaggtg aacgcccaat ggcagcagat   1260
aacaagactc ttggacgctt ccaattgact gatatcccag ctgcacctcg tggaattcct   1320
caaatcgaag taacatttga catcgacaag aacggtatcg tgtctgttaa ggccaaagac   1380
cttggaactc aaaaagaaca aactattgtc atccaatcga actcaggttt gactgacgaa   1440
gaaatcgacc gcatgatgaa agatgcagaa gcaaacgctg aagccgataa gaaacgtaaa   1500
gaagaagtag accttcgtaa tgaagtagac caagcaatct ttgcgactga aaagacaatc   1560
aaggaaactg aaggtaaagg cttcgacgca gaacgtgacg ctgcccaagc tgcccttgat   1620
gaccttaaga aagctcaaga agacaacaac ttggacgaca tgaaaacaaa acttgaagca   1680
ttgaacgaaa aagctcaagg acttgctgtt aaactctacg aacaagccgc agcagcgcaa   1740
caagctcaag aaggagcaga aggcgcacaa gcaacaggga acgcaggcga tgacgtcgta   1800
gacggagagt ttacggaaaa g                                             1821

<210>   896
<211>   607
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dnaK protein (dnaK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902499 (0.E+01)

<400>   896
Met Ser Lys Ile Ile Gly Ile Asp Leu Gly Thr Thr Asn Ser Ala Val 
1               5                   10                  15      


Ala Val Leu Glu Gly Thr Glu Ser Lys Ile Ile Ala Asn Pro Glu Gly 
            20                  25                  30          

Asn Arg Thr Thr Pro Ser Val Val Ser Phe Lys Asn Gly Glu Ile Ile 
        35                  40                  45              

Val Gly Asp Ala Ala Lys Arg Gln Ala Val Thr Asn Pro Asp Thr Val 
    50                  55                  60                  

Ile Ser Ile Lys Ser Lys Met Gly Thr Ser Glu Lys Val Ser Ala Asn 
65                  70                  75                  80  

Gly Lys Glu Tyr Thr Pro Gln Glu Ile Ser Ala Met Ile Leu Gln Tyr 
                85                  90                  95      

Leu Lys Gly Tyr Ala Glu Asp Tyr Leu Gly Glu Lys Val Thr Lys Ala 
            100                 105                 110         

Val Ile Thr Val Pro Ala Tyr Phe Asn Asp Ala Gln Arg Gln Ala Thr 
        115                 120                 125             

Lys Asp Ala Gly Lys Ile Ala Gly Leu Glu Val Glu Arg Ile Val Asn 
    130                 135                 140                 

Glu Pro Thr Ala Ala Ala Leu Ala Tyr Gly Leu Asp Lys Thr Asp Lys 
145                 150                 155                 160 

Glu Glu Lys Ile Leu Val Phe Asp Leu Gly Gly Gly Thr Phe Asp Val 
                165                 170                 175     

Ser Ile Leu Glu Leu Gly Asp Gly Val Phe Asp Val Leu Ser Thr Ala 
            180                 185                 190         

Gly Asp Asn Lys Leu Gly Gly Asp Asp Phe Asp Gln Lys Ile Ile Asp 
        195                 200                 205             

His Leu Val Ala Glu Phe Lys Lys Glu Asn Gly Ile Asp Leu Ser Thr 
    210                 215                 220                 

Asp Lys Met Ala Met Gln Arg Leu Lys Asp Ala Ala Glu Lys Ala Lys 
225                 230                 235                 240 

Lys Asp Leu Ser Gly Val Thr Ser Thr Gln Ile Ser Leu Pro Phe Ile 
                245                 250                 255     

Thr Ala Gly Glu Ala Gly Pro Leu His Leu Glu Met Thr Leu Thr Arg 
            260                 265                 270         

Ala Lys Phe Asp Asp Leu Thr Arg Asp Leu Val Glu Arg Thr Lys Val 
        275                 280                 285             

Pro Val Arg Gln Ala Leu Ser Asp Ala Gly Leu Ser Leu Ser Glu Ile 
    290                 295                 300                 

Asp Glu Val Ile Leu Val Gly Gly Ser Thr Arg Ile Pro Ala Val Val 
305                 310                 315                 320 

Glu Ala Val Lys Ala Glu Thr Gly Lys Glu Pro Asn Lys Ser Val Asn 
                325                 330                 335     

Pro Asp Glu Val Val Ala Met Gly Ala Ala Ile Gln Gly Gly Val Ile 
            340                 345                 350         


Thr Gly Asp Val Lys Asp Val Val Leu Leu Asp Val Thr Pro Leu Ser 
        355                 360                 365             

Leu Gly Ile Glu Thr Met Gly Gly Val Phe Thr Lys Leu Ile Asp Arg 
    370                 375                 380                 

Asn Thr Thr Ile Pro Thr Ser Lys Ser Gln Val Phe Ser Thr Ala Ala 
385                 390                 395                 400 

Asp Asn Gln Pro Ala Val Asp Ile His Val Leu Gln Gly Glu Arg Pro 
                405                 410                 415     

Met Ala Ala Asp Asn Lys Thr Leu Gly Arg Phe Gln Leu Thr Asp Ile 
            420                 425                 430         

Pro Ala Ala Pro Arg Gly Ile Pro Gln Ile Glu Val Thr Phe Asp Ile 
        435                 440                 445             

Asp Lys Asn Gly Ile Val Ser Val Lys Ala Lys Asp Leu Gly Thr Gln 
    450                 455                 460                 

Lys Glu Gln Thr Ile Val Ile Gln Ser Asn Ser Gly Leu Thr Asp Glu 
465                 470                 475                 480 

Glu Ile Asp Arg Met Met Lys Asp Ala Glu Ala Asn Ala Glu Ala Asp 
                485                 490                 495     

Lys Lys Arg Lys Glu Glu Val Asp Leu Arg Asn Glu Val Asp Gln Ala 
            500                 505                 510         

Ile Phe Ala Thr Glu Lys Thr Ile Lys Glu Thr Glu Gly Lys Gly Phe 
        515                 520                 525             

Asp Ala Glu Arg Asp Ala Ala Gln Ala Ala Leu Asp Asp Leu Lys Lys 
    530                 535                 540                 

Ala Gln Glu Asp Asn Asn Leu Asp Asp Met Lys Thr Lys Leu Glu Ala 
545                 550                 555                 560 

Leu Asn Glu Lys Ala Gln Gly Leu Ala Val Lys Leu Tyr Glu Gln Ala 
                565                 570                 575     

Ala Ala Ala Gln Gln Ala Gln Glu Gly Ala Glu Gly Ala Gln Ala Thr 
            580                 585                 590         

Gly Asn Ala Gly Asp Asp Val Val Asp Gly Glu Phe Thr Glu Lys 
        595                 600                 605         

<210>   897
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   897
atgagtgtat tggatgaaga gtatctaaaa aatacacgaa aagtttataa tgatttttgt   60
aatcaagctg ataactatag aacatcaaaa gattttattg ataatattcc aatagaatat   120
ttagctagat atagagaatt atat                                          144

<210>   898
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   898
Met Ser Val Leu Asp Glu Glu Tyr Leu Lys Asn Thr Arg Lys Val Tyr 
1               5                   10                  15      

Asn Asp Phe Cys Asn Gln Ala Asp Asn Tyr Arg Thr Ser Lys Asp Phe 
            20                  25                  30          

Ile Asp Asn Ile Pro Ile Glu Tyr Leu Ala Arg Tyr Arg Glu Leu Tyr 
        35                  40                  45              


<210>   899
<211>   1134
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   899
atgaacaata ctgaatttta tgatcgtctg ggggtatcca aaaacgcttc ggcagacgaa   60
atcaaaaagg cttatcgtaa gctttccaaa aaatatcacc cagatatcaa caaggagcct   120
ggtgctgagg acaagtacaa ggaagttcaa gaagcctatg agactttgag tgacgaccaa   180
aaacgtgctg cctatgacca gtatggtgct gcaggcgcca atggtggttt tggtggagct   240
ggtggtttcg gcggtttcaa tggggcaggt ggcttcggtg gttttgagga tattttctca   300
agtttcttcg gcggaggcgg ttcttcgcgc aatccaaacg ctcctcgcca aggagatgat   360
ctccagtatc gtgtcaattt gacctttgaa gaagctatct tcggaactga gaaggaagtt   420
aagtatcatc gtgaagctgg ctgtcgtaca tgtaatggat ctggtgctaa gccagggaca   480
agtccagtca cttgtggacg ctgtcatggc gctggtgtca ttaacgtcga tacgcagact   540
cctcttggta tgatgcgtcg ccaagtaacc tgtgatgtct gtcacggtcg aggaaaagaa   600
atcaaatatc catgtacaac ctgtcatgga acaggtcatg agaaacaagc tcatagcgta   660
catgtgaaaa tccctgctgg tgtggaaaca ggtcaacaaa ttcgcctcgc tggtcaaggt   720
gaagcaggct ttaacggtgg accttatggt gacttgtatg tagtagtttc tgtggaagct   780
agcgacaagt ttgaacgtga aggaacgact atcttctaca atctcaacct caactttgtc   840
caagcggctc ttggtgatac agtagatatt ccaactgttc acggtgatgt tgaattggtt   900
attccagagg gaactcagac tggtaagaag ttccgcctac gtagtaaggg ggcaccgagc   960
cttcgtggcg gtgcagttgg tgaccaatac gttactgtta atgtcgtaac accgacaggc   1020
ttgaacgacc gccaaaaagt agccttgaaa gaattcgcgg ctgctggtga cttgaaagta   1080
aatccaaaga aaaaaggctt ctttgaccat attaaagatg cctttgatgg agaa         1134

<210>   900
<211>   378
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dnaJ protein (dnaJ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902500 (0.E+01)

<400>   900
Met Asn Asn Thr Glu Phe Tyr Asp Arg Leu Gly Val Ser Lys Asn Ala 
1               5                   10                  15      

Ser Ala Asp Glu Ile Lys Lys Ala Tyr Arg Lys Leu Ser Lys Lys Tyr 
            20                  25                  30          

His Pro Asp Ile Asn Lys Glu Pro Gly Ala Glu Asp Lys Tyr Lys Glu 
        35                  40                  45              

Val Gln Glu Ala Tyr Glu Thr Leu Ser Asp Asp Gln Lys Arg Ala Ala 
    50                  55                  60                  

Tyr Asp Gln Tyr Gly Ala Ala Gly Ala Asn Gly Gly Phe Gly Gly Ala 
65                  70                  75                  80  

Gly Gly Phe Gly Gly Phe Asn Gly Ala Gly Gly Phe Gly Gly Phe Glu 
                85                  90                  95      

Asp Ile Phe Ser Ser Phe Phe Gly Gly Gly Gly Ser Ser Arg Asn Pro 
            100                 105                 110         

Asn Ala Pro Arg Gln Gly Asp Asp Leu Gln Tyr Arg Val Asn Leu Thr 
        115                 120                 125             

Phe Glu Glu Ala Ile Phe Gly Thr Glu Lys Glu Val Lys Tyr His Arg 
    130                 135                 140                 

Glu Ala Gly Cys Arg Thr Cys Asn Gly Ser Gly Ala Lys Pro Gly Thr 
145                 150                 155                 160 

Ser Pro Val Thr Cys Gly Arg Cys His Gly Ala Gly Val Ile Asn Val 
                165                 170                 175     

Asp Thr Gln Thr Pro Leu Gly Met Met Arg Arg Gln Val Thr Cys Asp 
            180                 185                 190         

Val Cys His Gly Arg Gly Lys Glu Ile Lys Tyr Pro Cys Thr Thr Cys 
        195                 200                 205             

His Gly Thr Gly His Glu Lys Gln Ala His Ser Val His Val Lys Ile 
    210                 215                 220                 

Pro Ala Gly Val Glu Thr Gly Gln Gln Ile Arg Leu Ala Gly Gln Gly 
225                 230                 235                 240 

Glu Ala Gly Phe Asn Gly Gly Pro Tyr Gly Asp Leu Tyr Val Val Val 

                245                 250                 255     

Ser Val Glu Ala Ser Asp Lys Phe Glu Arg Glu Gly Thr Thr Ile Phe 
            260                 265                 270         

Tyr Asn Leu Asn Leu Asn Phe Val Gln Ala Ala Leu Gly Asp Thr Val 
        275                 280                 285             

Asp Ile Pro Thr Val His Gly Asp Val Glu Leu Val Ile Pro Glu Gly 
    290                 295                 300                 

Thr Gln Thr Gly Lys Lys Phe Arg Leu Arg Ser Lys Gly Ala Pro Ser 
305                 310                 315                 320 

Leu Arg Gly Gly Ala Val Gly Asp Gln Tyr Val Thr Val Asn Val Val 
                325                 330                 335     

Thr Pro Thr Gly Leu Asn Asp Arg Gln Lys Val Ala Leu Lys Glu Phe 
            340                 345                 350         

Ala Ala Ala Gly Asp Leu Lys Val Asn Pro Lys Lys Lys Gly Phe Phe 
        355                 360                 365             

Asp His Ile Lys Asp Ala Phe Asp Gly Glu 
    370                 375             

<210>   901
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   901
gtggatagaa ctgacgaagt cagtaaccat acccatgaca agccgacgct gacgtggttt   60
gaagaaattt ttgaagagta tcattcacca tttcacaac                          99

<210>   902
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   902
Met Asp Arg Thr Asp Glu Val Ser Asn His Thr His Asp Lys Pro Thr 
1               5                   10                  15      

Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr His Ser Pro Phe His 
            20                  25                  30          

Asn 
    

<210>   903
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   903
atggttactg acttcgtcag ttctatccac aacctcaaaa cagtgtttga gctgacttcg   60
tcagttctat ccacaacctt aaaacggtgt tttgagcagt ctgtgcctag ctttctagtt   120
tgctttttga tttttattga gtatgaatta cctaaatta                          159

<210>   904
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   904
Met Val Thr Asp Phe Val Ser Ser Ile His Asn Leu Lys Thr Val Phe 
1               5                   10                  15      

Glu Leu Thr Ser Ser Val Leu Ser Thr Thr Leu Lys Arg Cys Phe Glu 
            20                  25                  30          

Gln Ser Val Pro Ser Phe Leu Val Cys Phe Leu Ile Phe Ile Glu Tyr 
        35                  40                  45              

Glu Leu Pro Lys Leu 
    50              

<210>   905
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   905
atgaaattat ccaacctact gctatttgca ggagctgcag ccggaagtta tctggttaca   60
aaaaatcgcc aaaccatcac agatgaagtc ttgaatacca ctgaccgcgt tcaagctatc   120
aaggacgatg tggatattat ccaaaacagc ctgcaaatca ttaaccagca aaaagaactt   180
atcaaggaat accaagaaga cttgacttac aagtttaagg tcttggaaaa ggatatccag   240
actagactag ctgtgataaa agaaatgcag ggaactgaag ataag                   285

<210>   906
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902501 (2.E-48)

<400>   906
Met Lys Leu Ser Asn Leu Leu Leu Phe Ala Gly Ala Ala Ala Gly Ser 
1               5                   10                  15      

Tyr Leu Val Thr Lys Asn Arg Gln Thr Ile Thr Asp Glu Val Leu Asn 
            20                  25                  30          

Thr Thr Asp Arg Val Gln Ala Ile Lys Asp Asp Val Asp Ile Ile Gln 
        35                  40                  45              

Asn Ser Leu Gln Ile Ile Asn Gln Gln Lys Glu Leu Ile Lys Glu Tyr 
    50                  55                  60                  

Gln Glu Asp Leu Thr Tyr Lys Phe Lys Val Leu Glu Lys Asp Ile Gln 
65                  70                  75                  80  

Thr Arg Leu Ala Val Ile Lys Glu Met Gln Gly Thr Glu Asp Lys 
                85                  90                  95  

<210>   907
<211>   408
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   907
atgtcagatt gcattttttg taaaatcatc gcaggggaaa ttcctgcttc aaaagtatat   60
gaagatgagc aggtccttgc ctttcttgat atctctcaag taacactagg acacaccttg   120
gtcgtgccaa aagaacacta tcgcaatctt ttggagatgg atgctacgag cgccagccaa   180
ctctttgccc aagtaccaaa agtagctcaa aaagtcatga aagtcactaa ggctgctggt   240

atgaatatca tttccaactg tgaagaagtc gctggtcaaa cagtttttca tactcacgtt   300
caccttgtgc ctcgctacag tgctgacgat gacctcaaga ttgattttat cgcccacgaa   360
ccagactttg acaaacttgc tcaagtcgct gaaaccatca aaaacgct                408

<210>   908
<211>   136
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   HIT family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902502 (7.E-75)

<400>   908
Met Ser Asp Cys Ile Phe Cys Lys Ile Ile Ala Gly Glu Ile Pro Ala 
1               5                   10                  15      

Ser Lys Val Tyr Glu Asp Glu Gln Val Leu Ala Phe Leu Asp Ile Ser 
            20                  25                  30          

Gln Val Thr Leu Gly His Thr Leu Val Val Pro Lys Glu His Tyr Arg 
        35                  40                  45              

Asn Leu Leu Glu Met Asp Ala Thr Ser Ala Ser Gln Leu Phe Ala Gln 
    50                  55                  60                  

Val Pro Lys Val Ala Gln Lys Val Met Lys Val Thr Lys Ala Ala Gly 
65                  70                  75                  80  

Met Asn Ile Ile Ser Asn Cys Glu Glu Val Ala Gly Gln Thr Val Phe 
                85                  90                  95      

His Thr His Val His Leu Val Pro Arg Tyr Ser Ala Asp Asp Asp Leu 
            100                 105                 110         

Lys Ile Asp Phe Ile Ala His Glu Pro Asp Phe Asp Lys Leu Ala Gln 
        115                 120                 125             

Val Ala Glu Thr Ile Lys Asn Ala 
    130                 135     

<210>   909
<211>   729
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   909
atgttagaaa ttaaaaacct gacaggtggc tatgttcatg ttcctgtttt gaaagatgtg   60
tcctttactg ttgaaagtgg gcagttggtc ggtttgattg gtctcaatgg tgctgggaaa   120
tcaacgacga tcaatgagat tatcggtctg ttggcacctt atagtggctc catcaatatc   180
aatggcctga ctctgcaagg agatgcgact agctaccgca agcagattgg ctacattcct   240
gagacgccta gtctgtatga ggaattgacc ctcagagagc atatcgaaac ggttgctatg   300
gcttacggta ttgagcaaaa agtggctttc gaacgagtag agcccttgtt aaaaatgttc   360
cgtttggaac agaaattaga ctggttccct gttcattttt caaaagggat gaagcagaag   420
gtcatgatta tctgtgcttt tgtggtggat ccaagtcttt tcatcgtgga tgagcctttc   480
cttggtcttg atccgctggc tatttctgat ttgattcagc ttttggaagt ggagaagcaa   540
aagggcaagt ctattctcat gagtacccac gtgctggatt cggcggagaa gatgtgtgat   600
gcctttgtca ttcttcacaa gggagaggtg cgttccaaag gcaatctcct gcaactacgt   660
gaagcctttg atatgcctga ggctagtttg aatgatattt acttggctct gaccaaagag   720
gaggatcta                                                           729

<210>   910
<211>   243
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902503 (e-135)

<400>   910
Met Leu Glu Ile Lys Asn Leu Thr Gly Gly Tyr Val His Val Pro Val 
1               5                   10                  15      

Leu Lys Asp Val Ser Phe Thr Val Glu Ser Gly Gln Leu Val Gly Leu 
            20                  25                  30          

Ile Gly Leu Asn Gly Ala Gly Lys Ser Thr Thr Ile Asn Glu Ile Ile 
        35                  40                  45              

Gly Leu Leu Ala Pro Tyr Ser Gly Ser Ile Asn Ile Asn Gly Leu Thr 
    50                  55                  60                  

Leu Gln Gly Asp Ala Thr Ser Tyr Arg Lys Gln Ile Gly Tyr Ile Pro 
65                  70                  75                  80  

Glu Thr Pro Ser Leu Tyr Glu Glu Leu Thr Leu Arg Glu His Ile Glu 
                85                  90                  95      

Thr Val Ala Met Ala Tyr Gly Ile Glu Gln Lys Val Ala Phe Glu Arg 
            100                 105                 110         

Val Glu Pro Leu Leu Lys Met Phe Arg Leu Glu Gln Lys Leu Asp Trp 
        115                 120                 125             

Phe Pro Val His Phe Ser Lys Gly Met Lys Gln Lys Val Met Ile Ile 
    130                 135                 140                 

Cys Ala Phe Val Val Asp Pro Ser Leu Phe Ile Val Asp Glu Pro Phe 
145                 150                 155                 160 

Leu Gly Leu Asp Pro Leu Ala Ile Ser Asp Leu Ile Gln Leu Leu Glu 
                165                 170                 175     

Val Glu Lys Gln Lys Gly Lys Ser Ile Leu Met Ser Thr His Val Leu 
            180                 185                 190         

Asp Ser Ala Glu Lys Met Cys Asp Ala Phe Val Ile Leu His Lys Gly 
        195                 200                 205             

Glu Val Arg Ser Lys Gly Asn Leu Leu Gln Leu Arg Glu Ala Phe Asp 
    210                 215                 220                 

Met Pro Glu Ala Ser Leu Asn Asp Ile Tyr Leu Ala Leu Thr Lys Glu 
225                 230                 235                 240 

Glu Asp Leu 
            

<210>   911
<211>   1047
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   911
atgaaagact tgtttttaaa gagaaagcag gcctttcgta aggagtgtct tggttatctg   60
cgctatgtgc tcaatgacca ctttgtcttg ttcctgcttg tcctgttggg ctttctagcc   120
taccagtaca gtcaactctt acaacatttt cctgaaaatc attggcctat ccttttgttt   180
gtaggaatta cgtctgtttt acttttactt tggggaggaa ctgccaccta tatggaggct   240
ccagacaagc tctttctctt agttggagaa gaggaaatta agctccatct caagcgtcaa   300
actggcattt ccctagtctt ttggctcttt gtacagaccc ttttcttgct gttatttgcg   360
cctttatttt tagcaatggg ttatggcttg ccagtttttc tgctctatgt gcttttattg   420
ggggtaggaa aatatttcca cttttgtcaa aaggccagca aatttttcac tgaaactgga   480
ctggactggg actatgttat ttctcaagaa agcaagcgta agcaagtctt gcttcgtttc   540
tttgccctct ttacgcaggt caagggaatt tcaaacagcg ttaagcgtcg tgcctatctg   600
gactttattt taaaggctgt tcagaaggtg cctgggaaga tttggcaaaa tctctatctg   660
cgttcttatc tgcgaaatgg cgacctcttt gctctcagtc ttcgtcttct cttgctttcc   720
ttgctggcgc aggtttttat cgagcaagct tggattgcga cagcagtggt agttctcttt   780
aactacctct tgctcttcca gttgctggcc ctctatcatg cctttgacta ccagtatttg   840
acccaactct ttccgctgga caaggggcaa aaggaaaaag gcttacagga ggtagttcga   900
ggattgacca gttttgtttt acttgtggaa ttagttgttg ggttgattac cttccaagaa   960
aaactagccc ttctagcctt actaggagct ggtttggttt tactagtctt gtatttgcct   1020
tatcaggtaa aacgtcagat gcaggac                                       1047

<210>   912
<211>   349
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902504 (0.E+01)

<400>   912
Met Lys Asp Leu Phe Leu Lys Arg Lys Gln Ala Phe Arg Lys Glu Cys 
1               5                   10                  15      

Leu Gly Tyr Leu Arg Tyr Val Leu Asn Asp His Phe Val Leu Phe Leu 
            20                  25                  30          

Leu Val Leu Leu Gly Phe Leu Ala Tyr Gln Tyr Ser Gln Leu Leu Gln 
        35                  40                  45              

His Phe Pro Glu Asn His Trp Pro Ile Leu Leu Phe Val Gly Ile Thr 
    50                  55                  60                  

Ser Val Leu Leu Leu Leu Trp Gly Gly Thr Ala Thr Tyr Met Glu Ala 
65                  70                  75                  80  

Pro Asp Lys Leu Phe Leu Leu Val Gly Glu Glu Glu Ile Lys Leu His 
                85                  90                  95      

Leu Lys Arg Gln Thr Gly Ile Ser Leu Val Phe Trp Leu Phe Val Gln 
            100                 105                 110         

Thr Leu Phe Leu Leu Leu Phe Ala Pro Leu Phe Leu Ala Met Gly Tyr 
        115                 120                 125             

Gly Leu Pro Val Phe Leu Leu Tyr Val Leu Leu Leu Gly Val Gly Lys 
    130                 135                 140                 

Tyr Phe His Phe Cys Gln Lys Ala Ser Lys Phe Phe Thr Glu Thr Gly 
145                 150                 155                 160 

Leu Asp Trp Asp Tyr Val Ile Ser Gln Glu Ser Lys Arg Lys Gln Val 
                165                 170                 175     

Leu Leu Arg Phe Phe Ala Leu Phe Thr Gln Val Lys Gly Ile Ser Asn 
            180                 185                 190         

Ser Val Lys Arg Arg Ala Tyr Leu Asp Phe Ile Leu Lys Ala Val Gln 
        195                 200                 205             

Lys Val Pro Gly Lys Ile Trp Gln Asn Leu Tyr Leu Arg Ser Tyr Leu 
    210                 215                 220                 

Arg Asn Gly Asp Leu Phe Ala Leu Ser Leu Arg Leu Leu Leu Leu Ser 
225                 230                 235                 240 

Leu Leu Ala Gln Val Phe Ile Glu Gln Ala Trp Ile Ala Thr Ala Val 
                245                 250                 255     

Val Val Leu Phe Asn Tyr Leu Leu Leu Phe Gln Leu Leu Ala Leu Tyr 
            260                 265                 270         

His Ala Phe Asp Tyr Gln Tyr Leu Thr Gln Leu Phe Pro Leu Asp Lys 
        275                 280                 285             

Gly Gln Lys Glu Lys Gly Leu Gln Glu Val Val Arg Gly Leu Thr Ser 
    290                 295                 300                 

Phe Val Leu Leu Val Glu Leu Val Val Gly Leu Ile Thr Phe Gln Glu 
305                 310                 315                 320 

Lys Leu Ala Leu Leu Ala Leu Leu Gly Ala Gly Leu Val Leu Leu Val 
                325                 330                 335     

Leu Tyr Leu Pro Tyr Gln Val Lys Arg Gln Met Gln Asp 
            340                 345                 

<210>   913
<211>   327
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   913
atgacagata cagaccccat caaaagagct catactttga ttactgactt aaacaaagcc   60
taccaagcat gcaaacaggc aagcgctgac gacgtccgct ttcaggagca attaaactct   120
attcttggtt ttctagccaa ggctgaaaca gtggataatc gattcttgat tgaactagaa   180
aaattttacc agacttccag tcttctcatg ggactcagcg ctcttgatcc agatgctcca   240
actcgcgccg cttggcgggc ctatgaccgc ttccactttg accaagtcaa gaccaagtta   300
atactcaatg aaaatcaaag agcaaac                                       327

<210>   914
<211>   109
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   BlpT protein, fusion (bplT)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902505 (1.E-58)

<400>   914
Met Thr Asp Thr Asp Pro Ile Lys Arg Ala His Thr Leu Ile Thr Asp 
1               5                   10                  15      


Leu Asn Lys Ala Tyr Gln Ala Cys Lys Gln Ala Ser Ala Asp Asp Val 
            20                  25                  30          

Arg Phe Gln Glu Gln Leu Asn Ser Ile Leu Gly Phe Leu Ala Lys Ala 
        35                  40                  45              

Glu Thr Val Asp Asn Arg Phe Leu Ile Glu Leu Glu Lys Phe Tyr Gln 
    50                  55                  60                  

Thr Ser Ser Leu Leu Met Gly Leu Ser Ala Leu Asp Pro Asp Ala Pro 
65                  70                  75                  80  

Thr Arg Ala Ala Trp Arg Ala Tyr Asp Arg Phe His Phe Asp Gln Val 
                85                  90                  95      

Lys Thr Lys Leu Ile Leu Asn Glu Asn Gln Arg Ala Asn 
            100                 105                 

<210>   915
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   915
atgaaatata tgattattca gacgcagaaa acagtctata aagtaaacat cgacgatatc   60
tactatatcc aaacacatcc aactaaagcc cataccgtac agattgttac agaagaagct   120
agttttaata tgcttcaaaa tttaagtaat cttgagaacc aatgtgggga aaccttgatg   180
agatgtcatc gaaattgttt ggttaatctt gataaattaa aatcgattga ttttcaagaa   240
agaatccttt ttctcggaga agaaggtcaa tacgctgtca agtatgccag acgtcgctat   300
agagaaattc gtcaaaaatg gttgaaagag ggagag                             336

<210>   916
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   blpS protein (blpS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902506 (4.E-60)

<400>   916
Met Lys Tyr Met Ile Ile Gln Thr Gln Lys Thr Val Tyr Lys Val Asn 
1               5                   10                  15      

Ile Asp Asp Ile Tyr Tyr Ile Gln Thr His Pro Thr Lys Ala His Thr 
            20                  25                  30          

Val Gln Ile Val Thr Glu Glu Ala Ser Phe Asn Met Leu Gln Asn Leu 
        35                  40                  45              

Ser Asn Leu Glu Asn Gln Cys Gly Glu Thr Leu Met Arg Cys His Arg 
    50                  55                  60                  

Asn Cys Leu Val Asn Leu Asp Lys Leu Lys Ser Ile Asp Phe Gln Glu 
65                  70                  75                  80  

Arg Ile Leu Phe Leu Gly Glu Glu Gly Gln Tyr Ala Val Lys Tyr Ala 
                85                  90                  95      

Arg Arg Arg Tyr Arg Glu Ile Arg Gln Lys Trp Leu Lys Glu Gly Glu 
            100                 105                 110         


<210>   917
<211>   735
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   917
atgagaatat ttgttttaga ggatgatttt tcccaacaga ctagaattga aacgacgatt   60
gagaaacttt tgaaagcaca tcatatcatt cctagctctt ttgaggtatt tggcaagccg   120
gaccaactgc tggctgaagt gcatgagaag ggggcccatc agctattctt tttggatatt   180
gagattcgaa atgaagagat gaagggactg gaagtggcta gaaagattcg ggatcgggat   240
ccttatgccc tgattgtctt tgtgacgact cactcggagt ttatgcccct gtcttttcgc   300
taccaagtgt ctgctttgga ctacattgat aaggccttgt cagcagagga gtttgaatct   360
cggatcgaga cagccctcct ctatgccaat agtcaagata gtaaaagtct ggcggaagat   420
tgcttttact ttaaatcaaa atttgcccaa tttcagtatc cttttaaaga ggtttactat   480
ctcgaaacgt cgcccagagc ccatcgtgtt attctctata ccaagacaga caggctggaa   540
tttacagcga gtttagagga ggttttcaag caggagcccc gtctcttgca gtgccaccgc   600
tcttttctca tcaatcctgc aaatgtggtg catttggata agaaagaaaa actgcttttc   660
tttcccaatg gtggaagttg tctaatcgcc cgttataagg tcagggaagt gtctgaggcc   720
atcaataaat tacac                                                    735

<210>   918
<211>   245
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   response regulator BlpR (blpR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902507 (e-135)

<400>   918
Met Arg Ile Phe Val Leu Glu Asp Asp Phe Ser Gln Gln Thr Arg Ile 
1               5                   10                  15      

Glu Thr Thr Ile Glu Lys Leu Leu Lys Ala His His Ile Ile Pro Ser 
            20                  25                  30          

Ser Phe Glu Val Phe Gly Lys Pro Asp Gln Leu Leu Ala Glu Val His 
        35                  40                  45              

Glu Lys Gly Ala His Gln Leu Phe Phe Leu Asp Ile Glu Ile Arg Asn 
    50                  55                  60                  

Glu Glu Met Lys Gly Leu Glu Val Ala Arg Lys Ile Arg Asp Arg Asp 
65                  70                  75                  80  

Pro Tyr Ala Leu Ile Val Phe Val Thr Thr His Ser Glu Phe Met Pro 
                85                  90                  95      


Leu Ser Phe Arg Tyr Gln Val Ser Ala Leu Asp Tyr Ile Asp Lys Ala 
            100                 105                 110         

Leu Ser Ala Glu Glu Phe Glu Ser Arg Ile Glu Thr Ala Leu Leu Tyr 
        115                 120                 125             

Ala Asn Ser Gln Asp Ser Lys Ser Leu Ala Glu Asp Cys Phe Tyr Phe 
    130                 135                 140                 

Lys Ser Lys Phe Ala Gln Phe Gln Tyr Pro Phe Lys Glu Val Tyr Tyr 
145                 150                 155                 160 

Leu Glu Thr Ser Pro Arg Ala His Arg Val Ile Leu Tyr Thr Lys Thr 
                165                 170                 175     

Asp Arg Leu Glu Phe Thr Ala Ser Leu Glu Glu Val Phe Lys Gln Glu 
            180                 185                 190         

Pro Arg Leu Leu Gln Cys His Arg Ser Phe Leu Ile Asn Pro Ala Asn 
        195                 200                 205             

Val Val His Leu Asp Lys Lys Glu Lys Leu Leu Phe Phe Pro Asn Gly 
    210                 215                 220                 

Gly Ser Cys Leu Ile Ala Arg Tyr Lys Val Arg Glu Val Ser Glu Ala 
225                 230                 235                 240 

Ile Asn Lys Leu His 
                245 

<210>   919
<211>   1338
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   919
atgaacattg cttggatatt gttgtataca cttgttacta atggactaga aattgtcatc   60
ttctttaagg tggatggaat tgatcttact ttcgagagga tttttaaggc ctttcttttg   120
aagatactgt tggcctttgt ttttgtgatg attagctata tagtaggaaa tgtttaccta   180
tcttatttta tggaaccctt gtacggcata ggcttatctt tcttattatt gagagggctt   240
cctaaaaaac tccttttctt ttatggtctc tttccaatga tattggtgaa tctcttttat   300
agaggagtct cctattttgt gcttccattt ttgggacaag ggcaagtata tgatggctac   360
tcatttactg ggttatgtat aataattttc aatttcttca tttctctagc ttttttgaaa   420
tggttggact acgattttac tagcttgaga aaggagattc tcgataaagc ctttcaaaag   480
tccctgactc agattaactg gataatgggt ggctactatc tagtcatgga aagtctgtct   540
ttttttgaat atgaacaaag tattcaatca aagactgttc gccatctcat cctagtcttt   600
tacctactct tttttatggg ggttatcaag aaattggata cctatttgaa ggaaaaactc   660
tatgagagat tggaacaaga gcaggccctg cgctatagag atatggaacg ctatagtcgg   720
catatagagg agctttacaa ggaagtacgg agctttcgtc atgattatac caacctcttg   780
actagcttac gtctgggcat tgaagaggag gatatggagc agataaaaga ggtctatggc   840
tccgtcttaa aggattccag tcagaaattg cagaacaata aatatgacct gggcagattg   900
gtaaatattc gtgataaagc cctcaaaagt cttctagcag ggaaattttt aaaagccaga   960
gataagaaca ttgtctttaa tgtcgaagtt cctgaggaga ttcaggtcga ggggatgagt   1020
ctacttgatt ttctaaccat tgtgtctatc ctttgtgaca atgctattga agccagtgtg   1080
gaagctagtc aacctcatgt ttcaatcgcc tttttaaaaa atggagcaca ggagaccttt   1140
atcatcgaaa actccatcaa agaagagggc atcgatattt ctgaaatctt ctcctttgga   1200
gccagttcta aaggggagga gagaggagtt ggtctctata ccgtcatgaa gattgtggaa   1260
agccatccta ataccagtct aaataccacc tgtcaaaatc aagtctttcg tcaggtactt   1320
actgtgatac atacagaa                                                 1338

<210>   920
<211>   446
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   putative histidine kinase BlpH (blpH)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902508 (0.E+01)

<400>   920
Met Asn Ile Ala Trp Ile Leu Leu Tyr Thr Leu Val Thr Asn Gly Leu 
1               5                   10                  15      

Glu Ile Val Ile Phe Phe Lys Val Asp Gly Ile Asp Leu Thr Phe Glu 
            20                  25                  30          

Arg Ile Phe Lys Ala Phe Leu Leu Lys Ile Leu Leu Ala Phe Val Phe 
        35                  40                  45              

Val Met Ile Ser Tyr Ile Val Gly Asn Val Tyr Leu Ser Tyr Phe Met 
    50                  55                  60                  

Glu Pro Leu Tyr Gly Ile Gly Leu Ser Phe Leu Leu Leu Arg Gly Leu 
65                  70                  75                  80  


Pro Lys Lys Leu Leu Phe Phe Tyr Gly Leu Phe Pro Met Ile Leu Val 
                85                  90                  95      

Asn Leu Phe Tyr Arg Gly Val Ser Tyr Phe Val Leu Pro Phe Leu Gly 
            100                 105                 110         

Gln Gly Gln Val Tyr Asp Gly Tyr Ser Phe Thr Gly Leu Cys Ile Ile 
        115                 120                 125             

Ile Phe Asn Phe Phe Ile Ser Leu Ala Phe Leu Lys Trp Leu Asp Tyr 
    130                 135                 140                 

Asp Phe Thr Ser Leu Arg Lys Glu Ile Leu Asp Lys Ala Phe Gln Lys 
145                 150                 155                 160 

Ser Leu Thr Gln Ile Asn Trp Ile Met Gly Gly Tyr Tyr Leu Val Met 
                165                 170                 175     

Glu Ser Leu Ser Phe Phe Glu Tyr Glu Gln Ser Ile Gln Ser Lys Thr 
            180                 185                 190         

Val Arg His Leu Ile Leu Val Phe Tyr Leu Leu Phe Phe Met Gly Val 
        195                 200                 205             

Ile Lys Lys Leu Asp Thr Tyr Leu Lys Glu Lys Leu Tyr Glu Arg Leu 
    210                 215                 220                 

Glu Gln Glu Gln Ala Leu Arg Tyr Arg Asp Met Glu Arg Tyr Ser Arg 
225                 230                 235                 240 

His Ile Glu Glu Leu Tyr Lys Glu Val Arg Ser Phe Arg His Asp Tyr 
                245                 250                 255     

Thr Asn Leu Leu Thr Ser Leu Arg Leu Gly Ile Glu Glu Glu Asp Met 
            260                 265                 270         

Glu Gln Ile Lys Glu Val Tyr Gly Ser Val Leu Lys Asp Ser Ser Gln 
        275                 280                 285             

Lys Leu Gln Asn Asn Lys Tyr Asp Leu Gly Arg Leu Val Asn Ile Arg 
    290                 295                 300                 

Asp Lys Ala Leu Lys Ser Leu Leu Ala Gly Lys Phe Leu Lys Ala Arg 
305                 310                 315                 320 

Asp Lys Asn Ile Val Phe Asn Val Glu Val Pro Glu Glu Ile Gln Val 
                325                 330                 335     

Glu Gly Met Ser Leu Leu Asp Phe Leu Thr Ile Val Ser Ile Leu Cys 
            340                 345                 350         

Asp Asn Ala Ile Glu Ala Ser Val Glu Ala Ser Gln Pro His Val Ser 
        355                 360                 365             

Ile Ala Phe Leu Lys Asn Gly Ala Gln Glu Thr Phe Ile Ile Glu Asn 
    370                 375                 380                 

Ser Ile Lys Glu Glu Gly Ile Asp Ile Ser Glu Ile Phe Ser Phe Gly 
385                 390                 395                 400 

Ala Ser Ser Lys Gly Glu Glu Arg Gly Val Gly Leu Tyr Thr Val Met 
                405                 410                 415     


Lys Ile Val Glu Ser His Pro Asn Thr Ser Leu Asn Thr Thr Cys Gln 
            420                 425                 430         

Asn Gln Val Phe Arg Gln Val Leu Thr Val Ile His Thr Glu 
        435                 440                 445     

<210>   921
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   921
atggataaga aacaaaacct aacttcattt caagaactaa caactaccga actcaatcaa   60
attacaggtg gaggattgtg ggaagattta ttatataaca ttaatagata tgctcattac   120
atcaca                                                              126

<210>   922
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptide pheromone BlpC (blpC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902509 (1.E-12)

<400>   922
Met Asp Lys Lys Gln Asn Leu Thr Ser Phe Gln Glu Leu Thr Thr Thr 
1               5                   10                  15      

Glu Leu Asn Gln Ile Thr Gly Gly Gly Leu Trp Glu Asp Leu Leu Tyr 
            20                  25                  30          

Asn Ile Asn Arg Tyr Ala His Tyr Ile Thr 
        35                  40          

<210>   923
<211>   1359
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   923
atgaatccta atctttttag aagcgtcgag ttttatcaga gacgttacca taactatgcg   60
acagtgttaa ttatacctct ttcattacta tttactttca tcttgatttt ctcccttgtt   120
gccacaaaag aaattactgt tacttcccaa ggagaaatcg cccctacaag tgtcattgcc   180
tccattcagt caaccagtga taatcctatc ctagctaatc atttagtggc aaatcaagta   240
gttgaaaaag gggacttact catcaaatac tctgaaacaa tggaagaaag tcagaaaact   300
gccttagcaa ctcaattaca aagacttgag aagcaaaaag aaggacttgg aattttgaaa   360
caaagcttag aaaaagcgac tgatcttttt tctggcgagg atgaatttgg ctaccataat   420
acctttatga attttactaa acaatcccat gatattgaac tgggtatcac aaagactaac   480
accgaagttt caaatcaagc taatctttcc aatagcagtt catcagctat tgaacaagaa   540
attacaaaag ttcaacaaca aattggagaa tatcaagagt tgagagatgc tatcataaat   600
aacagagcac gcttaccaac tggcaatccg caccagtcaa ttttgaatcg ttatcttgta   660
gcctcacaag gacaaacaca aggaactgca gaggagccat ttttatctca aattaatcaa   720
agtattgcag gtcttgaatc atctatcgca agcctcaaaa ttcagcaagc tggtatcgga   780
agtgtagcaa cttatgataa cagtttagca accaaaattg aagtactccg cactcagttt   840
ttacagacag cctcacagca acaactaact gtggagaatc aattaacaga attaaaagta   900
caactagatc aagccacaca gcgtttggaa aacaatacct taacctcccc aagtaaaggt   960
atcgttcatc tgaacagcga atttgaaggt aaaaatagaa ttccaactgg tacagaaatt   1020
gctcaaatat tccctgtcat cacagataca agagaagtac taatcactta ctacgtatct   1080
tctgactatc tacctctact agataaagga caaactgtaa gattaaaact ggagaagatt   1140
ggaaatcacg gcaccaccat catcggccaa cttcagacaa ttgatcaaac tcctaccaga   1200
acagagcaag gaaatctctt taaattaacc gctcttgcaa aactatctaa cgaggatagt   1260
aaactcatcc aatatggctt acaaggtcgc gtcactagtg taactacaaa gaaaacatat   1320
tttgattatt tcaaagataa aattttaaca cattctgat                          1359

<210>   924
<211>   453
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transport protein BlpB (blpB)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902510 (0.E+01)

<400>   924
Met Asn Pro Asn Leu Phe Arg Ser Val Glu Phe Tyr Gln Arg Arg Tyr 
1               5                   10                  15      

His Asn Tyr Ala Thr Val Leu Ile Ile Pro Leu Ser Leu Leu Phe Thr 
            20                  25                  30          

Phe Ile Leu Ile Phe Ser Leu Val Ala Thr Lys Glu Ile Thr Val Thr 
        35                  40                  45              

Ser Gln Gly Glu Ile Ala Pro Thr Ser Val Ile Ala Ser Ile Gln Ser 
    50                  55                  60                  

Thr Ser Asp Asn Pro Ile Leu Ala Asn His Leu Val Ala Asn Gln Val 
65                  70                  75                  80  

Val Glu Lys Gly Asp Leu Leu Ile Lys Tyr Ser Glu Thr Met Glu Glu 
                85                  90                  95      

Ser Gln Lys Thr Ala Leu Ala Thr Gln Leu Gln Arg Leu Glu Lys Gln 
            100                 105                 110         

Lys Glu Gly Leu Gly Ile Leu Lys Gln Ser Leu Glu Lys Ala Thr Asp 
        115                 120                 125             

Leu Phe Ser Gly Glu Asp Glu Phe Gly Tyr His Asn Thr Phe Met Asn 
    130                 135                 140                 

Phe Thr Lys Gln Ser His Asp Ile Glu Leu Gly Ile Thr Lys Thr Asn 
145                 150                 155                 160 

Thr Glu Val Ser Asn Gln Ala Asn Leu Ser Asn Ser Ser Ser Ser Ala 
                165                 170                 175     

Ile Glu Gln Glu Ile Thr Lys Val Gln Gln Gln Ile Gly Glu Tyr Gln 
            180                 185                 190         

Glu Leu Arg Asp Ala Ile Ile Asn Asn Arg Ala Arg Leu Pro Thr Gly 
        195                 200                 205             

Asn Pro His Gln Ser Ile Leu Asn Arg Tyr Leu Val Ala Ser Gln Gly 
    210                 215                 220                 

Gln Thr Gln Gly Thr Ala Glu Glu Pro Phe Leu Ser Gln Ile Asn Gln 
225                 230                 235                 240 

Ser Ile Ala Gly Leu Glu Ser Ser Ile Ala Ser Leu Lys Ile Gln Gln 
                245                 250                 255     

Ala Gly Ile Gly Ser Val Ala Thr Tyr Asp Asn Ser Leu Ala Thr Lys 
            260                 265                 270         

Ile Glu Val Leu Arg Thr Gln Phe Leu Gln Thr Ala Ser Gln Gln Gln 
        275                 280                 285             

Leu Thr Val Glu Asn Gln Leu Thr Glu Leu Lys Val Gln Leu Asp Gln 
    290                 295                 300                 

Ala Thr Gln Arg Leu Glu Asn Asn Thr Leu Thr Ser Pro Ser Lys Gly 
305                 310                 315                 320 

Ile Val His Leu Asn Ser Glu Phe Glu Gly Lys Asn Arg Ile Pro Thr 
                325                 330                 335     

Gly Thr Glu Ile Ala Gln Ile Phe Pro Val Ile Thr Asp Thr Arg Glu 
            340                 345                 350         

Val Leu Ile Thr Tyr Tyr Val Ser Ser Asp Tyr Leu Pro Leu Leu Asp 
        355                 360                 365             

Lys Gly Gln Thr Val Arg Leu Lys Leu Glu Lys Ile Gly Asn His Gly 
    370                 375                 380                 

Thr Thr Ile Ile Gly Gln Leu Gln Thr Ile Asp Gln Thr Pro Thr Arg 
385                 390                 395                 400 

Thr Glu Gln Gly Asn Leu Phe Lys Leu Thr Ala Leu Ala Lys Leu Ser 
                405                 410                 415     

Asn Glu Asp Ser Lys Leu Ile Gln Tyr Gly Leu Gln Gly Arg Val Thr 
            420                 425                 430         

Ser Val Thr Thr Lys Lys Thr Tyr Phe Asp Tyr Phe Lys Asp Lys Ile 
        435                 440                 445             

Leu Thr His Ser Asp 
    450             

<210>   925
<211>   1575
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   925
ttggatgaat acattccaaa tcagatgaaa tcaactttag gaatcatctc agttggtctg   60
gttatcacct atatcctcca acaagtcatg agcttctcca gagattatct cctaaccgtt   120
ctgagtcaga gattaagtat tgatgtgatt ttatcctata ttcgccatat ttttgaactt   180
cccatgtctt tctttgcgac acgtcgtaca ggagaaatca tttcacgatt cacagatgct   240
aactctatta tagatgcctt ggcttctacc attctttctc tttttctgga tgtttctatt   300
ctgattcttg taggaggcgt cttactggca caaaacccta atctcttcct tctttctctt   360
atttccattc ctatatacat gttcatcatc ttttctttta tgaaaccttt cgaaaaaatg   420
aaccatgatg tcatgcaaag taattctatg gttagctctg ccattatcga agatatcaac   480
gggattgaaa ctataaagtc gctcacgagt gaagaaaatc gctatcaaaa tatagacagc   540
gaatttgtag attatttgga aaaatccttt aagctcagta aatattctat tttacaaacg   600
agtttaaagc agggaacaaa attagttctg aatatcctta tcctatggtt tggcgctcaa   660
ttagtcatgt caagtaaaat ttctatcggt cagctgatta cctttaacac acttttttct   720
tactttacaa ctcctatgga aaatattatc aacctccaaa ccaaactcca atctgcgaag   780
gtcgctaata accgtttgaa cgaagtctat ctagtcgaat ctgaatttca agttcaagaa   840
aaccctgttc attcacattt tttgatgggc gatattgaat ttgatgacct ttcttataag   900
tatggttttg gatgagatac cttaacagat attaatctca cgattaaaca aggagataag   960
gttagcctag ttggagttag tggttctggt aaaacaactt tagccaaaat gattgtcaat   1020
ttctttgaac cctacaaagg gcatatttcc atcaatcatc aggatattaa aaacattgat   1080
aaaaaagtct tgcgccgtca tattaattac ctaccccaac aagcctatat ctttaatggc   1140
tctattttgg aaaacttaac cttgggcggt aatcatatga ttagtcaaga agatattcta   1200
aaagcttgtg aagtagctga aatccgtcaa gacattgaaa gaatgcctat gggctatcaa   1260
actcagctct ctgatggagc tggtctatca ggaggacaga agcaacgaat cgctctcgct   1320
cgtgctcttt taactaaatc tcctgtttta atactagatg aagctactag cggtcttgat   1380
gtcttgactg agaaaaaggt tatagataat cttatgtctc taactgataa aaccattctc   1440
tttgtagccc atcgtctcag tatagccgaa cgaaccaacc gtgtcattgt tcttgaccag   1500
gggaaaatca ttgaagttgg tagtcaccaa gagttaatgc aggcgcaagg tttctaccat   1560
catctattca ataaa                                                    1575


<210>   926
<400>   926
000

<210>   927
<211>   591
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   927
ttgccaatga cttcttataa acgtacattt gttcctcaaa tagatgcgag agactgtggt   60
gtcgctgcct tagcctcgat tgctaaattc tatggttcag atttttctct agctcacttg   120
agagaacttg caaagaccaa taaagaaggg acgactgctc ttggcattgt aaaagccgct   180
gatgaaatgg gctttgaaac aagacctgtt caagcagata aaacgctctt tgacatgagt   240
gatgtcccct atccatttat cgttcacgtt aacaaagaag gaaaactcca acattactat   300
gttgtctatc aaacaaagaa agactatctg attattggtg atcctgaccc ttctgtaaaa   360
atcactaaaa tgtcaaaaga acgctttttc tatgaatgga ctggagtagc tatttttcta   420
gctaccaaac ccagctatca accccataaa gataaaaaga atggtctact aagcaagctt   480
ccttcctctg attttcaaac aaaaatctct cattgcttac attgttctct caagcttatt   540
ggtcactatt atcaatatag gtggttctta ctatctccaa ggaatcttgg a            591

<210>   928
<211>   197
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   antibiotic ABC exporter BlpA, FRAMESHIFT (blpA)

<400>   928
Met Pro Met Thr Ser Tyr Lys Arg Thr Phe Val Pro Gln Ile Asp Ala 
1               5                   10                  15      

Arg Asp Cys Gly Val Ala Ala Leu Ala Ser Ile Ala Lys Phe Tyr Gly 
            20                  25                  30          

Ser Asp Phe Ser Leu Ala His Leu Arg Glu Leu Ala Lys Thr Asn Lys 
        35                  40                  45              

Glu Gly Thr Thr Ala Leu Gly Ile Val Lys Ala Ala Asp Glu Met Gly 
    50                  55                  60                  

Phe Glu Thr Arg Pro Val Gln Ala Asp Lys Thr Leu Phe Asp Met Ser 
65                  70                  75                  80  

Asp Val Pro Tyr Pro Phe Ile Val His Val Asn Lys Glu Gly Lys Leu 
                85                  90                  95      

Gln His Tyr Tyr Val Val Tyr Gln Thr Lys Lys Asp Tyr Leu Ile Ile 
            100                 105                 110         

Gly Asp Pro Asp Pro Ser Val Lys Ile Thr Lys Met Ser Lys Glu Arg 
        115                 120                 125             

Phe Phe Tyr Glu Trp Thr Gly Val Ala Ile Phe Leu Ala Thr Lys Pro 
    130                 135                 140                 

Ser Tyr Gln Pro His Lys Asp Lys Lys Asn Gly Leu Leu Ser Lys Leu 
145                 150                 155                 160 

Pro Ser Ser Asp Phe Gln Thr Lys Ile Ser His Cys Leu His Cys Ser 
                165                 170                 175     

Leu Lys Leu Ile Gly His Tyr Tyr Gln Tyr Arg Trp Phe Leu Leu Ser 
            180                 185                 190         

Pro Arg Asn Leu Gly 
        195         

<210>   929
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   929
atgaatacaa aaatgatgga acaattttct gttatggata atgaagaact cgaaatagtt   60
agtggaggaa gaggcaattt aggatctgca atcggtggtt gtattggagc agtactatta   120
gctgctgcga ctggtccgat aactggggga gcagcaacac ttatttgtgt aggttcagga   180
attatgtcct ctttg                                                    195

<210>   930
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacteriocin BlpI (blpI)
<223>   Cellular location: membrane

<400>   930
Met Asn Thr Lys Met Met Glu Gln Phe Ser Val Met Asp Asn Glu Glu 
1               5                   10                  15      

Leu Glu Ile Val Ser Gly Gly Arg Gly Asn Leu Gly Ser Ala Ile Gly 
            20                  25                  30          

Gly Cys Ile Gly Ala Val Leu Leu Ala Ala Ala Thr Gly Pro Ile Thr 
        35                  40                  45              

Gly Gly Ala Ala Thr Leu Ile Cys Val Gly Ser Gly Ile Met Ser Ser 
    50                  55                  60                  

Leu 
65  

<210>   931
<211>   267
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   931
atgaatacaa aaatgttgtc acagttagag gttatggata ctgaaatgct tgcgaaagtt   60
gaaggggggt atagctccac tgattgtcaa aatgcactga ttacaggagt cactacggga   120
attataactg gtggaactgg agcaggtttg gccactttag gagtagctgg acttgctggt   180
gcatttgttg gagcacacat tggtgcaatt gggggtggat taacatgctt aggaggtatg   240
gttggtgata aattgggact aagttgg                                       267

<210>   932
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacteriocin BlpJ (blpJ)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902084 (3.E-07)

<400>   932
Met Asn Thr Lys Met Leu Ser Gln Leu Glu Val Met Asp Thr Glu Met 
1               5                   10                  15      

Leu Ala Lys Val Glu Gly Gly Tyr Ser Ser Thr Asp Cys Gln Asn Ala 
            20                  25                  30          

Leu Ile Thr Gly Val Thr Thr Gly Ile Ile Thr Gly Gly Thr Gly Ala 
        35                  40                  45              

Gly Leu Ala Thr Leu Gly Val Ala Gly Leu Ala Gly Ala Phe Val Gly 
    50                  55                  60                  

Ala His Ile Gly Ala Ile Gly Gly Gly Leu Thr Cys Leu Gly Gly Met 
65                  70                  75                  80  

Val Gly Asp Lys Leu Gly Leu Ser Trp 
                85                  

<210>   933
<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   933
atggatacaa aaatgatgtc acaattttct gttatggata ctgaaatgct tgcttgcgtt   60
gaaggtggcg gatgcaattg gggagatttt gccaaagcag gtgttggagg aggagcagca   120
agaggtcttc aactaggcat taaaacagga acatggcaag gtgcagcaac tggtgctgcg   180
ggtggagcta tacttggagg tgtagcctat gcagcaacat gttggtgg                228

<210>   934
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacteriocin BlpK (blpK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902084 (1.E-39)

<400>   934
Met Asp Thr Lys Met Met Ser Gln Phe Ser Val Met Asp Thr Glu Met 
1               5                   10                  15      

Leu Ala Cys Val Glu Gly Gly Gly Cys Asn Trp Gly Asp Phe Ala Lys 
            20                  25                  30          

Ala Gly Val Gly Gly Gly Ala Ala Arg Gly Leu Gln Leu Gly Ile Lys 
        35                  40                  45              

Thr Gly Thr Trp Gln Gly Ala Ala Thr Gly Ala Ala Gly Gly Ala Ile 
    50                  55                  60                  

Leu Gly Gly Val Ala Tyr Ala Ala Thr Cys Trp Trp 
65                  70                  75      


<210>   935
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   935
ttggtatcaa tacaatataa agaggaaagt atgtttttca tgcttgcttt tttaattttt   60
acaattcaag aggttttgat gaccatttat gatttgagtg atccaaggtc aaaa         114

<210>   936
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   936
Met Val Ser Ile Gln Tyr Lys Glu Glu Ser Met Phe Phe Met Leu Ala 
1               5                   10                  15      

Phe Leu Ile Phe Thr Ile Gln Glu Val Leu Met Thr Ile Tyr Asp Leu 
            20                  25                  30          

Ser Asp Pro Arg Ser Lys 
        35              

<210>   937
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   937
ttgagcaaga acatttacac tgctagtata gcacttattt tgaccttgga tcactcaaat   60
cataaatggt catcaaaacc tcttgaattg                                    90

<210>   938
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   938
Met Ser Lys Asn Ile Tyr Thr Ala Ser Ile Ala Leu Ile Leu Thr Leu 
1               5                   10                  15      

Asp His Ser Asn His Lys Trp Ser Ser Lys Pro Leu Glu Leu 
            20                  25                  30  

<210>   939
<211>   162
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   939
atgaagaaaa aaatactgat tattttcgtt ctgtatctaa tcatgtccat ctttctatat   60
ccgcttaggg agagtgcttg gtatcagcta ttttatacca tagcctatgt gattgcagtt   120
atgatctatt ttgctatcaa taaaaagaaa ggagaaaaga aa                      162

<210>   940
<211>   54
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside

<400>   940
Met Lys Lys Lys Ile Leu Ile Ile Phe Val Leu Tyr Leu Ile Met Ser 
1               5                   10                  15      

Ile Phe Leu Tyr Pro Leu Arg Glu Ser Ala Trp Tyr Gln Leu Phe Tyr 
            20                  25                  30          

Thr Ile Ala Tyr Val Ile Ala Val Met Ile Tyr Phe Ala Ile Asn Lys 
        35                  40                  45              

Lys Lys Gly Glu Lys Lys 
    50                  

<210>   941
<211>   402
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   941
atgaaaactt ttcttgctaa aaaacggaac atcttccttg cgagattgtt cttaggtcag   60
ttgcccttgc ttgtttctac ttatctattt ctatctcgtc agtttttaaa tttttccgta   120
gttttccaat ttcttttagt agttattaac ttggcttcta ttttggttac tgtttatctc   180
actagggaaa tgaggataag agagtttgaa gatgatgatt tggttagtcc tagaaccaat   240
caacttatgt tcatcggctt gacaggtttt atgtctatta tttgtttgta tagaggtatc   300
acagcaggag aatcctacca acaaataatc gcttatattg gcgctgttct ctgcttaatc   360
atcatgcttc tgctcatgtg gggcttgaag tattataaaa ag                      402

<210>   942
<211>   134
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   immunity protein BlpL (blpL)
<223>   Cellular location: membrane

<400>   942
Met Lys Thr Phe Leu Ala Lys Lys Arg Asn Ile Phe Leu Ala Arg Leu 
1               5                   10                  15      

Phe Leu Gly Gln Leu Pro Leu Leu Val Ser Thr Tyr Leu Phe Leu Ser 
            20                  25                  30          

Arg Gln Phe Leu Asn Phe Ser Val Val Phe Gln Phe Leu Leu Val Val 
        35                  40                  45              

Ile Asn Leu Ala Ser Ile Leu Val Thr Val Tyr Leu Thr Arg Glu Met 
    50                  55                  60                  

Arg Ile Arg Glu Phe Glu Asp Asp Asp Leu Val Ser Pro Arg Thr Asn 
65                  70                  75                  80  

Gln Leu Met Phe Ile Gly Leu Thr Gly Phe Met Ser Ile Ile Cys Leu 
                85                  90                  95      

Tyr Arg Gly Ile Thr Ala Gly Glu Ser Tyr Gln Gln Ile Ile Ala Tyr 
            100                 105                 110         

Ile Gly Ala Val Leu Cys Leu Ile Ile Met Leu Leu Leu Met Trp Gly 
        115                 120                 125             

Leu Lys Tyr Tyr Lys Lys 
    130                 

<210>   943
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   943
atgaattatg aagcaagtaa acaactaact gatgcacgat ttaagcgtct tgttggtgtt   60
cagcgcacga cttttgaaga gatgctagct gtattaaaaa cagcttatca acttaaacac   120
gcaaaaggtg gacgaaaacc taaattaagc ctagaagacc ttcttatggc cactcttcaa   180
tatgtgcgag aataccgcac ttatgaagaa attgcggctg attttggtgt tcacgaaagc   240
aacttactcc gtcggagcca atgggttgaa gtaactcttg ttcaaagtgg tgttacgatt   300
tcaagaactc ctctcagttc tgaggacacg gtaatgattg atgcgacgga agtaaaaatc   360
aatcgcccta aaaaaagaat tagcgaa                                       387

<210>   944
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902886 (5.E-67)

<400>   944
Met Asn Tyr Glu Ala Ser Lys Gln Leu Thr Asp Ala Arg Phe Lys Arg 
1               5                   10                  15      

Leu Val Gly Val Gln Arg Thr Thr Phe Glu Glu Met Leu Ala Val Leu 
            20                  25                  30          

Lys Thr Ala Tyr Gln Leu Lys His Ala Lys Gly Gly Arg Lys Pro Lys 
        35                  40                  45              

Leu Ser Leu Glu Asp Leu Leu Met Ala Thr Leu Gln Tyr Val Arg Glu 
    50                  55                  60                  

Tyr Arg Thr Tyr Glu Glu Ile Ala Ala Asp Phe Gly Val His Glu Ser 
65                  70                  75                  80  

Asn Leu Leu Arg Arg Ser Gln Trp Val Glu Val Thr Leu Val Gln Ser 
                85                  90                  95      

Gly Val Thr Ile Ser Arg Thr Pro Leu Ser Ser Glu Asp Thr Val Met 
            100                 105                 110         

Ile Asp Ala Thr Glu Val Lys Ile Asn Arg Pro Lys Lys Arg Ile Ser 
        115                 120                 125             

Glu 
    

<210>   945

<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   945
atgaagactc aagcgattgt cacaagtcaa gggagaattg tttctttgga tatcactgtg   60
aactattgtc atgatatgaa gttgttcaaa atgagtcgca gaaatatcgg acaagctggt   120
aaaatcttgg ctgacagtgg ttatcaaggg ctcatgaaga tatatcctca agcacaaact   180
tcacgtaaat ccagcaaact caaaccgcta acagttgaag ataaagcctg taaccatgcg   240
ctatctaagg agagaagcaa ggttgagaac atctttgcca aagtaaaaac gtttaaaatg   300
ttttcaacaa cctatcgaag tcatcgtaaa cgcttcggat tacgaatgaa tttgagtgct   360

ggtattatca atcatgaact aggattc                                       387

<210>   946
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfB FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902885 (5.E-69)

<400>   946
Met Lys Thr Gln Ala Ile Val Thr Ser Gln Gly Arg Ile Val Ser Leu 
1               5                   10                  15      

Asp Ile Thr Val Asn Tyr Cys His Asp Met Lys Leu Phe Lys Met Ser 
            20                  25                  30          

Arg Arg Asn Ile Gly Gln Ala Gly Lys Ile Leu Ala Asp Ser Gly Tyr 
        35                  40                  45              

Gln Gly Leu Met Lys Ile Tyr Pro Gln Ala Gln Thr Ser Arg Lys Ser 
    50                  55                  60                  

Ser Lys Leu Lys Pro Leu Thr Val Glu Asp Lys Ala Cys Asn His Ala 
65                  70                  75                  80  

Leu Ser Lys Glu Arg Ser Lys Val Glu Asn Ile Phe Ala Lys Val Lys 
                85                  90                  95      

Thr Phe Lys Met Phe Ser Thr Thr Tyr Arg Ser His Arg Lys Arg Phe 
            100                 105                 110         

Gly Leu Arg Met Asn Leu Ser Ala Gly Ile Ile Asn His Glu Leu Gly 
        115                 120                 125             

Phe 
    

<210>   947
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   947
atggatacaa aaattatgga acaatttcat gaaatggata taactatgtt atctagtatt   60
gaaggaggca agaataattg gcaaactaat gtcttagaag gtggtggtgc tgcttttggt   120

ggctgggggc tagggacagc tatttgtgct gcgagtggtg ttggagcacc atttatggga   180
gcatgtggat acataggagc taaatttggt gtggatcttt gggcaggagt aacaggggca   240
acgggtggat tt                                                       252

<210>   948
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacteriocin BlpM (blpM)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902084 (2.E-05)

<400>   948
Met Asp Thr Lys Ile Met Glu Gln Phe His Glu Met Asp Ile Thr Met 
1               5                   10                  15      

Leu Ser Ser Ile Glu Gly Gly Lys Asn Asn Trp Gln Thr Asn Val Leu 
            20                  25                  30          

Glu Gly Gly Gly Ala Ala Phe Gly Gly Trp Gly Leu Gly Thr Ala Ile 
        35                  40                  45              

Cys Ala Ala Ser Gly Val Gly Ala Pro Phe Met Gly Ala Cys Gly Tyr 
    50                  55                  60                  

Ile Gly Ala Lys Phe Gly Val Asp Leu Trp Ala Gly Val Thr Gly Ala 
65                  70                  75                  80  

Thr Gly Gly Phe 
                

<210>   949
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   949
gtgatacact atatggatac aaaaatgatg tcacaatttg cagttatgga taatgaaatg   60
cttgcttgcg ttgaaggtgg agatattgat tggggaagaa aaattagttg tgcagcaggg   120
gttgcatatg gcgcaattga tgggtgtgca acaacggtt                          159

<210>   950
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacteriocin BlpO (blpO)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902084 (4.E-09)

<400>   950
Met Ile His Tyr Met Asp Thr Lys Met Met Ser Gln Phe Ala Val Met 
1               5                   10                  15      

Asp Asn Glu Met Leu Ala Cys Val Glu Gly Gly Asp Ile Asp Trp Gly 
            20                  25                  30          

Arg Lys Ile Ser Cys Ala Ala Gly Val Ala Tyr Gly Ala Ile Asp Gly 
        35                  40                  45              

Cys Ala Thr Thr Val 
    50              

<210>   951
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   951
gtgtgcaaca acggtttgac atttctattg ggaccatttg ctataggaat aggtgtaact   60
ggtgctgcag gtggagctat acttggaggt gtagcctatg cagcaatatg ttggtgg      117

<210>   952
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Amphipathic pore-forming)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902084 (2.E-07)

<400>   952
Met Cys Asn Asn Gly Leu Thr Phe Leu Leu Gly Pro Phe Ala Ile Gly 
1               5                   10                  15      

Ile Gly Val Thr Gly Ala Ala Gly Gly Ala Ile Leu Gly Gly Val Ala 
            20                  25                  30          

Tyr Ala Ala Ile Cys Trp Trp 
        35                  

<210>   953
<211>   165
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   953
ttggttagtc ctagaaccaa tcaacttatg tttatcggct tggcagattt tatgtttgtc   60
atttgtttgt atagaggtat ttcagaaaca gaattctatc aacaactaat cgcttatata   120
ggtgtattct ctgcttgttt atcacgcttc tgctcatgtg gggct                   165

<210>   954
<211>   55
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   954
Met Val Ser Pro Arg Thr Asn Gln Leu Met Phe Ile Gly Leu Ala Asp 
1               5                   10                  15      

Phe Met Phe Val Ile Cys Leu Tyr Arg Gly Ile Ser Glu Thr Glu Phe 
            20                  25                  30          

Tyr Gln Gln Leu Ile Ala Tyr Ile Gly Val Phe Ser Ala Cys Leu Ser 
        35                  40                  45              

Arg Phe Cys Ser Cys Gly Ala 
    50                  55  

<210>   955
<211>   396
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   955
atggaggtat ttaatatgaa atacagatta ttttttgtta ttttcttgag tagtgtgttg   60
gatattcttt tagggacatt tttacaaatc tctatcgtat ctattgggtg gcttgttctt   120
tacagtggtt tgtttgaagc aggagttttc cttcttgcta ataaaggggt ggcggtaaaa   180
atcaaggaag tagatattcg aaatcgcttt aaatttattt ttggaaaaac cttatggttt   240
caaattcttt tgctcatctt tttgataatc aaactttatc ttggtttgga tgcgaggttg   300
attttattct atggacatat tttcattgtc tttaatgcct taatgtatct attatctagt   360
agtcaggtta gccttaaaaa aaacaaactg tcttct                             396

<210>   956
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   immunity protein BlpX (blpX)
<223>   Cellular location: membrane

<400>   956
Met Glu Val Phe Asn Met Lys Tyr Arg Leu Phe Phe Val Ile Phe Leu 
1               5                   10                  15      

Ser Ser Val Leu Asp Ile Leu Leu Gly Thr Phe Leu Gln Ile Ser Ile 
            20                  25                  30          

Val Ser Ile Gly Trp Leu Val Leu Tyr Ser Gly Leu Phe Glu Ala Gly 
        35                  40                  45              

Val Phe Leu Leu Ala Asn Lys Gly Val Ala Val Lys Ile Lys Glu Val 
    50                  55                  60                  

Asp Ile Arg Asn Arg Phe Lys Phe Ile Phe Gly Lys Thr Leu Trp Phe 
65                  70                  75                  80  

Gln Ile Leu Leu Leu Ile Phe Leu Ile Ile Lys Leu Tyr Leu Gly Leu 
                85                  90                  95      

Asp Ala Arg Leu Ile Leu Phe Tyr Gly His Ile Phe Ile Val Phe Asn 
            100                 105                 110         

Ala Leu Met Tyr Leu Leu Ser Ser Ser Gln Val Ser Leu Lys Lys Asn 
        115                 120                 125             

Lys Leu Ser Ser 
    130         

<210>   957
<211>   687
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   957
atgaaaaagt atcaacttct attcaaaata agtgcagtct tctcttactt atttttcgta   60
tttagtcttt ctcagctgac gcttatcgtc caaaactatt ggcaattttc ttctcagata   120
ggcaatttat tctggattca aaatatcttg agtttacttt ttattggagt catgattgtg   180
gttcttgtta agacaggcca tggttatctc ttccgcattc caagaaaaaa atggctttgg   240
tattcgattt tgacagtatt agtgctagtg ttccagatct cttttaacgt tcagacagct   300
aaacatgttc agtcaactgc ggaaggttgg gctgtattga ttggttatag tgggactaac   360
tttgcagagc taggtattta tatagccctg ttctttctgg ttccactgat ggaagaattg   420
atttatagag gattactgca acatgctttc tttaagcatt cgcgatttgg tcttgatttg   480
cttcttcctt ctattttatt tgctctccct catttttcaa gcctgcctag tctgttagat   540
atcttcgtct ttgcaacagt tggaatcatc tttgctggtt tgacccgcta taccaagagc   600
atttatccat cctatgcggt gcatgtgatc aataatattg tagcgacctt cccgtttttg   660
ctcacttttc tacatagggt cttgggg                                       687

<210>   958
<211>   229
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   immunity protein BlpY (blpY)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902516 (e-122)

<400>   958
Met Lys Lys Tyr Gln Leu Leu Phe Lys Ile Ser Ala Val Phe Ser Tyr 
1               5                   10                  15      

Leu Phe Phe Val Phe Ser Leu Ser Gln Leu Thr Leu Ile Val Gln Asn 
            20                  25                  30          

Tyr Trp Gln Phe Ser Ser Gln Ile Gly Asn Leu Phe Trp Ile Gln Asn 
        35                  40                  45              

Ile Leu Ser Leu Leu Phe Ile Gly Val Met Ile Val Val Leu Val Lys 
    50                  55                  60                  

Thr Gly His Gly Tyr Leu Phe Arg Ile Pro Arg Lys Lys Trp Leu Trp 
65                  70                  75                  80  

Tyr Ser Ile Leu Thr Val Leu Val Leu Val Phe Gln Ile Ser Phe Asn 
                85                  90                  95      

Val Gln Thr Ala Lys His Val Gln Ser Thr Ala Glu Gly Trp Ala Val 
            100                 105                 110         

Leu Ile Gly Tyr Ser Gly Thr Asn Phe Ala Glu Leu Gly Ile Tyr Ile 
        115                 120                 125             

Ala Leu Phe Phe Leu Val Pro Leu Met Glu Glu Leu Ile Tyr Arg Gly 
    130                 135                 140                 

Leu Leu Gln His Ala Phe Phe Lys His Ser Arg Phe Gly Leu Asp Leu 
145                 150                 155                 160 

Leu Leu Pro Ser Ile Leu Phe Ala Leu Pro His Phe Ser Ser Leu Pro 
                165                 170                 175     

Ser Leu Leu Asp Ile Phe Val Phe Ala Thr Val Gly Ile Ile Phe Ala 
            180                 185                 190         

Gly Leu Thr Arg Tyr Thr Lys Ser Ile Tyr Pro Ser Tyr Ala Val His 
        195                 200                 205             

Val Ile Asn Asn Ile Val Ala Thr Phe Pro Phe Leu Leu Thr Phe Leu 
    210                 215                 220                 

His Arg Val Leu Gly 
225                 

<210>   959
<211>   231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   959
atgtataaac acttattttt cctagattcc aaaactttag atcggttgac accctatatt   60
ctagtcttgg cttctgacac cattgctttt aatgtttttg tgctaacctt tgtatctgcg   120
gtggttttta atttcctaaa ttccatgcta gctttaatgg ctatattcat aggggctggc   180
tatgtggtcg gattttggtt actaatactc aatgaaaatc aaagagcaaa c            231

<210>   960
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   BlpZ protein, fusion (blpZ)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902517 (2.E-39)

<400>   960
Met Tyr Lys His Leu Phe Phe Leu Asp Ser Lys Thr Leu Asp Arg Leu 
1               5                   10                  15      

Thr Pro Tyr Ile Leu Val Leu Ala Ser Asp Thr Ile Ala Phe Asn Val 
            20                  25                  30          

Phe Val Leu Thr Phe Val Ser Ala Val Val Phe Asn Phe Leu Asn Ser 
        35                  40                  45              

Met Leu Ala Leu Met Ala Ile Phe Ile Gly Ala Gly Tyr Val Val Gly 
    50                  55                  60                  

Phe Trp Leu Leu Ile Leu Asn Glu Asn Gln Arg Ala Asn 
65                  70                  75          

<210>   961
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   961
atgaaattta tcaaaaaact ccataaaatt atcctcctca acaaacagac ttcctacacg   60
tcattcttta gttctagcct ttccaaaaca aaccatttta tactcttcga aaatcaaatt   120
caaaccacgt caacgtcgcc ttgccgtact caagtacagc ctgcggctag tttcctagtt   180
tgctctttga ttttcattga gtat                                          204

<210>   962
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   962
Met Lys Phe Ile Lys Lys Leu His Lys Ile Ile Leu Leu Asn Lys Gln 
1               5                   10                  15      

Thr Ser Tyr Thr Ser Phe Phe Ser Ser Ser Leu Ser Lys Thr Asn His 
            20                  25                  30          

Phe Ile Leu Phe Glu Asn Gln Ile Gln Thr Thr Ser Thr Ser Pro Cys 
        35                  40                  45              

Arg Thr Gln Val Gln Pro Ala Ala Ser Phe Leu Val Cys Ser Leu Ile 
    50                  55                  60                  

Phe Ile Glu Tyr 
65              

<210>   963
<211>   609
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   963
atggagtttt ttgataaatt tcatgccttg tgttttggat ttttagtact aataattgtc   60
attacagttc cttatacgat taaccatggg ggtttttttc aaaatgaatc tgcattgatt   120
cttgtaagtc ttcttgtaac ctcgctgagt gttgcttatg ctagaaagtt tgaaatgatt   180
tcttttggga tgttaagcaa gaaacaactt ttgcttttca ttgcaatctt tcttctaagt   240
gtacttgaga cgctggttta tattcatttc ttcgctgttt cttctggctc aggggtccaa   300
cacttggcgg aagtcagcag aggaatttcc ctgtctttga ttttgactac ctcagttttt   360
ggccccatcc aggaggaact cattttcaga ggacttcttc aaggtgcggt ttttgacaat   420
tcttggttag ggcttgtgct aacttcctct ctcttttctt tcatgcatgg accttctaat   480
gtcccttcgt ttatttttta tctacttggg ggtttgttgc tgggctttgc ttataaaaag   540
agtcaaaacc tatgggtttc tactctagtc catatgcttt acaacagttg gccactctta   600
tattattta                                                           609

<210>   964
<211>   203
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein (ABC transporter ATP)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902518 (e-110)

<400>   964
Met Glu Phe Phe Asp Lys Phe His Ala Leu Cys Phe Gly Phe Leu Val 
1               5                   10                  15      

Leu Ile Ile Val Ile Thr Val Pro Tyr Thr Ile Asn His Gly Gly Phe 
            20                  25                  30          

Phe Gln Asn Glu Ser Ala Leu Ile Leu Val Ser Leu Leu Val Thr Ser 
        35                  40                  45              

Leu Ser Val Ala Tyr Ala Arg Lys Phe Glu Met Ile Ser Phe Gly Met 
    50                  55                  60                  

Leu Ser Lys Lys Gln Leu Leu Leu Phe Ile Ala Ile Phe Leu Leu Ser 
65                  70                  75                  80  

Val Leu Glu Thr Leu Val Tyr Ile His Phe Phe Ala Val Ser Ser Gly 
                85                  90                  95      

Ser Gly Val Gln His Leu Ala Glu Val Ser Arg Gly Ile Ser Leu Ser 
            100                 105                 110         

Leu Ile Leu Thr Thr Ser Val Phe Gly Pro Ile Gln Glu Glu Leu Ile 
        115                 120                 125             

Phe Arg Gly Leu Leu Gln Gly Ala Val Phe Asp Asn Ser Trp Leu Gly 
    130                 135                 140                 

Leu Val Leu Thr Ser Ser Leu Phe Ser Phe Met His Gly Pro Ser Asn 
145                 150                 155                 160 

Val Pro Ser Phe Ile Phe Tyr Leu Leu Gly Gly Leu Leu Leu Gly Phe 
                165                 170                 175     

Ala Tyr Lys Lys Ser Gln Asn Leu Trp Val Ser Thr Leu Val His Met 
            180                 185                 190         

Leu Tyr Asn Ser Trp Pro Leu Leu Tyr Tyr Leu 
        195                 200             

<210>   965
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   965
ttgccacttt tcccaggtat gggagtcagt gttagctcat tatcacccaa atccatttct   60
ttcctccgta taaagtttcc ttactattct actagttttt ggcctattcg tcaaccactc   120

<210>   966
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   966
Met Pro Leu Phe Pro Gly Met Gly Val Ser Val Ser Ser Leu Ser Pro 
1               5                   10                  15      

Lys Ser Ile Ser Phe Leu Arg Ile Lys Phe Pro Tyr Tyr Ser Thr Ser 
            20                  25                  30          

Phe Trp Pro Ile Arg Gln Pro Leu 
        35                  40  

<210>   967
<211>   729
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   967
atgggtagct atcctgatgg gaagcgcatc tttgtaaaaa tgaacacctc tccaatccta   60
cctggtctag ctagagaaca aattgctcca caattattat ggagtcgtcg tttggcagat   120
gggcgtgata tgtgtgctca agaatggttg acaggcaaga tattgacccc ctatgatatg   180
aatcgtaagc aaatcgtcaa tattttaacc cgtcttcatc gctcacgtcc gttgatgaca   240
caattgagtc gtttgggcta tgccatggaa acacctgtag atttactaca gtcttggcag   300
gaaacggctc cagatgcttt gcgtaaaaat cattttatca gtgaagtgat ggctgattta   360
cgtcagacta ttccaggatt tagagaggac catgcgacca ttgtccatgg agatgtacga   420
catagtaatt ggattgagac agatagtggc ttgatttatt tagtagattg ggattcggtt   480
cgcttgaccg atcgcatgtt tgatgtggcc catatgctct gccattatat ttcagaacat   540
cagtggaagg aatggttgac ctactacggt tacaagtaca atcaaacggt attaagtaaa   600
ttgtattggt atggtcaatt gtcttatttg agtcagattt ccaagtatta tatgaaccaa   660
gatttagaaa atgtcaatcg ggagattcat ggtttgcgtc atttccgaga caagtatgga   720
aagagaaga                                                           729

<210>   968
<211>   243
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902519 (e-146)

<400>   968
Met Gly Ser Tyr Pro Asp Gly Lys Arg Ile Phe Val Lys Met Asn Thr 
1               5                   10                  15      

Ser Pro Ile Leu Pro Gly Leu Ala Arg Glu Gln Ile Ala Pro Gln Leu 
            20                  25                  30          

Leu Trp Ser Arg Arg Leu Ala Asp Gly Arg Asp Met Cys Ala Gln Glu 
        35                  40                  45              

Trp Leu Thr Gly Lys Ile Leu Thr Pro Tyr Asp Met Asn Arg Lys Gln 
    50                  55                  60                  

Ile Val Asn Ile Leu Thr Arg Leu His Arg Ser Arg Pro Leu Met Thr 
65                  70                  75                  80  

Gln Leu Ser Arg Leu Gly Tyr Ala Met Glu Thr Pro Val Asp Leu Leu 
                85                  90                  95      

Gln Ser Trp Gln Glu Thr Ala Pro Asp Ala Leu Arg Lys Asn His Phe 
            100                 105                 110         

Ile Ser Glu Val Met Ala Asp Leu Arg Gln Thr Ile Pro Gly Phe Arg 
        115                 120                 125             

Glu Asp His Ala Thr Ile Val His Gly Asp Val Arg His Ser Asn Trp 
    130                 135                 140                 

Ile Glu Thr Asp Ser Gly Leu Ile Tyr Leu Val Asp Trp Asp Ser Val 
145                 150                 155                 160 

Arg Leu Thr Asp Arg Met Phe Asp Val Ala His Met Leu Cys His Tyr 
                165                 170                 175     

Ile Ser Glu His Gln Trp Lys Glu Trp Leu Thr Tyr Tyr Gly Tyr Lys 
            180                 185                 190         

Tyr Asn Gln Thr Val Leu Ser Lys Leu Tyr Trp Tyr Gly Gln Leu Ser 
        195                 200                 205             

Tyr Leu Ser Gln Ile Ser Lys Tyr Tyr Met Asn Gln Asp Leu Glu Asn 
    210                 215                 220                 

Val Asn Arg Glu Ile His Gly Leu Arg His Phe Arg Asp Lys Tyr Gly 
225                 230                 235                 240 

Lys Arg Arg 
            

<210>   969
<211>   633
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   969
atgagagtta gaaatcgtaa aggggcaaca gaattactag aggcaaatcc ccagtatgtg   60
gtcctcaatc ccttggaagc caaggcaaaa tggcgggact tgtttggcaa tgataatccc   120
attcatgtgg aagttggaag tggaaagggt gcctttgttt caggtatggc caagcaaaac   180
cctgacatca actatatcgg gattgatatt caaaagtctg ttttgagcta cgctttggac   240
aaggtgcttg aagttggagt gcctaacatc aagctcttgt gggtagatgg ttctgactta   300
actgactact ttgaagacgg tgagattgat cgcttgtatc tgaacttttc agatccatgg   360
ccgaaaaaac gccatgaaaa gcgtcgtttg acctacaaga ccttcttgga taccttcaaa   420
cgtatcttgc ctgaaaatgg agaaattcat ttcaagacgg ataaccgtgg cttgtttgag   480
tacagtttag tgagcttttc tcaatatggc atgaaactca atggtgtctg gttagatttg   540
catgccagtg attttgaagg caatgtcatg acagaatacg agcaaaaatt ctcaaacaag   600
gggcaagtta tctaccgagt tgaggcagaa ttt                                633

<210>   970
<211>   211
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902520 (e-123)

<400>   970
Met Arg Val Arg Asn Arg Lys Gly Ala Thr Glu Leu Leu Glu Ala Asn 
1               5                   10                  15      

Pro Gln Tyr Val Val Leu Asn Pro Leu Glu Ala Lys Ala Lys Trp Arg 
            20                  25                  30          

Asp Leu Phe Gly Asn Asp Asn Pro Ile His Val Glu Val Gly Ser Gly 
        35                  40                  45              

Lys Gly Ala Phe Val Ser Gly Met Ala Lys Gln Asn Pro Asp Ile Asn 
    50                  55                  60                  

Tyr Ile Gly Ile Asp Ile Gln Lys Ser Val Leu Ser Tyr Ala Leu Asp 
65                  70                  75                  80  

Lys Val Leu Glu Val Gly Val Pro Asn Ile Lys Leu Leu Trp Val Asp 
                85                  90                  95      

Gly Ser Asp Leu Thr Asp Tyr Phe Glu Asp Gly Glu Ile Asp Arg Leu 
            100                 105                 110         

Tyr Leu Asn Phe Ser Asp Pro Trp Pro Lys Lys Arg His Glu Lys Arg 
        115                 120                 125             

Arg Leu Thr Tyr Lys Thr Phe Leu Asp Thr Phe Lys Arg Ile Leu Pro 
    130                 135                 140                 

Glu Asn Gly Glu Ile His Phe Lys Thr Asp Asn Arg Gly Leu Phe Glu 
145                 150                 155                 160 

Tyr Ser Leu Val Ser Phe Ser Gln Tyr Gly Met Lys Leu Asn Gly Val 
                165                 170                 175     

Trp Leu Asp Leu His Ala Ser Asp Phe Glu Gly Asn Val Met Thr Glu 
            180                 185                 190         

Tyr Glu Gln Lys Phe Ser Asn Lys Gly Gln Val Ile Tyr Arg Val Glu 
        195                 200                 205             

Ala Glu Phe 
    210     

<210>   971
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   971
gtggacgcaa tcgcaacaat cgtagaatta gtcagagaag ttgtagaacc tgtcatagaa   60
gctccttttg aactcgtgga tatcgagtat ggaaagattg gcagtgacat gattctcagt   120
atttttgtag ataaacccga agaattacct                                    150

<210>   972
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902521 (6.E-86)

<400>   972
Met Asp Ala Ile Ala Thr Ile Val Glu Leu Val Arg Glu Val Val Glu 
1               5                   10                  15      

Pro Val Ile Glu Ala Pro Phe Glu Leu Val Asp Ile Glu Tyr Gly Lys 
            20                  25                  30          

Ile Gly Ser Asp Met Ile Leu Ser Ile Phe Val Asp Lys Pro Glu Glu 
        35                  40                  45              

Leu Pro 
    50  

<210>   973
<211>   327
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   973
ttgaacgaca cggcagactt gacagaaatt atcagtcctg tcctagacac catcaagcca   60
gatcccttcc cagaacaata tttcctagaa attaccagtc caggtttgga acgtcctttg   120
aaaaccaagg atgccgtcgc tggagcggtt ggaaaataca tccatgtcgg gctctaccaa   180
gccatcgata agcaaaaggt ctttgaagga accttgttgg ccttcgaaga ggacgagttg   240
actatggaat atatggacaa gacgcgtaag aaaaccgtcc aaattccata cagtttagta   300
tcaaaagcac gtttagcagt taaatta                                       327

<210>   974
<211>   109
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, FRAMESHIFT

<400>   974
Met Asn Asp Thr Ala Asp Leu Thr Glu Ile Ile Ser Pro Val Leu Asp 
1               5                   10                  15      

Thr Ile Lys Pro Asp Pro Phe Pro Glu Gln Tyr Phe Leu Glu Ile Thr 
            20                  25                  30          

Ser Pro Gly Leu Glu Arg Pro Leu Lys Thr Lys Asp Ala Val Ala Gly 
        35                  40                  45              

Ala Val Gly Lys Tyr Ile His Val Gly Leu Tyr Gln Ala Ile Asp Lys 
    50                  55                  60                  

Gln Lys Val Phe Glu Gly Thr Leu Leu Ala Phe Glu Glu Asp Glu Leu 
65                  70                  75                  80  

Thr Met Glu Tyr Met Asp Lys Thr Arg Lys Lys Thr Val Gln Ile Pro 
                85                  90                  95      

Tyr Ser Leu Val Ser Lys Ala Arg Leu Ala Val Lys Leu 
            100                 105                 

<210>   975
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   975
ttgtcttctt ccaaaatgcg gaaggcctct agcatttctt tactcatgtt ttcttcactt   60
ttgaatcctc aaaagctatc ctttcttttt cta                                93

<210>   976
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   976
Met Ser Ser Ser Lys Met Arg Lys Ala Ser Ser Ile Ser Leu Leu Met 
1               5                   10                  15      

Phe Ser Ser Leu Leu Asn Pro Gln Lys Leu Ser Phe Leu Phe Leu 
            20                  25                  30      

<210>   977
<211>   1134
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   977
atgagtaaag aaatgctaga ggccttccgc attttggaag aagacaaggg aatcaaaaaa   60
gaagatatca tcgacgcagt agtagagtcg cttcgttccg cttatcgcag acgctatggt   120
cagtcagaca gcgtagctat tgacttcaac gaaaaaacag gtgactttac agtttatact   180
gtccgtgaag ttgttgatga agtatttgat agccgtttgg aaatcagctt gaaagatgct   240
cttgccatta attcagctta tgaacttgga gacaaaatca agtttgaaga agcaccagct   300
gagtttggtc gtgtagcagc ccaatctgcc aaacaaacca tcatggaaaa aatgcgcaag   360
caaacacgtg ccatcactta caatacttac aaagaacatg agcaagaaat catgtctggt   420
acagtagaac gctttgacaa ccgctttatc tatgtcaacc ttggtagcat cgaagcccaa   480
ttgtcaaaac aagaccaaat tcctggagaa gtttttgctt ctcatgatcg tatcgaagtt   540
tatgtttaca aggttgaaga caaccctcgt ggtgtgaacg tctttgttag ccgtagtcat   600
ccagaaatga tcaaacgttt aatggagcaa gaaattccag aagtttatga tggaactgtt   660
gaaatcatga gcgtggctcg tgaagcaggt gaccgtacga aggttgctgt tcgtagccac   720
aatccaaacg tggatgctat cggtacaatc gttggacgtg gtggtgctaa tatcaagaag   780
attactagca aattccaccc agctcgttac gatgctaaaa atgaccgcat ggtaccaatc   840
gaagaaaata tcgatgttat cgagtgggta gcagatccag ctgaatttat ctacaatgcc   900
atcgctcctg ctgaggttga ccaagttatc tttgatgaaa acgacagcaa acgtgccttg   960
gtggttgttc cagataacaa gctttctctt gccattggtc gtcgtggaca aaacgtgcgc   1020
ttggcggctc acttgactgg ttaccgtatc gatatcaagt ctgctagcga atttgaagcc   1080
atggaagacg ctgcttcagt agagttggaa gtagaaaacg atactgtaga agaa         1134

<210>   978
<211>   378
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   N utilization substance protein A (nusA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902522 (0.E+01)

<400>   978
Met Ser Lys Glu Met Leu Glu Ala Phe Arg Ile Leu Glu Glu Asp Lys 
1               5                   10                  15      

Gly Ile Lys Lys Glu Asp Ile Ile Asp Ala Val Val Glu Ser Leu Arg 
            20                  25                  30          

Ser Ala Tyr Arg Arg Arg Tyr Gly Gln Ser Asp Ser Val Ala Ile Asp 
        35                  40                  45              

Phe Asn Glu Lys Thr Gly Asp Phe Thr Val Tyr Thr Val Arg Glu Val 
    50                  55                  60                  

Val Asp Glu Val Phe Asp Ser Arg Leu Glu Ile Ser Leu Lys Asp Ala 
65                  70                  75                  80  

Leu Ala Ile Asn Ser Ala Tyr Glu Leu Gly Asp Lys Ile Lys Phe Glu 
                85                  90                  95      

Glu Ala Pro Ala Glu Phe Gly Arg Val Ala Ala Gln Ser Ala Lys Gln 
            100                 105                 110         

Thr Ile Met Glu Lys Met Arg Lys Gln Thr Arg Ala Ile Thr Tyr Asn 
        115                 120                 125             

Thr Tyr Lys Glu His Glu Gln Glu Ile Met Ser Gly Thr Val Glu Arg 
    130                 135                 140                 

Phe Asp Asn Arg Phe Ile Tyr Val Asn Leu Gly Ser Ile Glu Ala Gln 
145                 150                 155                 160 

Leu Ser Lys Gln Asp Gln Ile Pro Gly Glu Val Phe Ala Ser His Asp 
                165                 170                 175     

Arg Ile Glu Val Tyr Val Tyr Lys Val Glu Asp Asn Pro Arg Gly Val 
            180                 185                 190         

Asn Val Phe Val Ser Arg Ser His Pro Glu Met Ile Lys Arg Leu Met 
        195                 200                 205             

Glu Gln Glu Ile Pro Glu Val Tyr Asp Gly Thr Val Glu Ile Met Ser 
    210                 215                 220                 

Val Ala Arg Glu Ala Gly Asp Arg Thr Lys Val Ala Val Arg Ser His 
225                 230                 235                 240 

Asn Pro Asn Val Asp Ala Ile Gly Thr Ile Val Gly Arg Gly Gly Ala 
                245                 250                 255     

Asn Ile Lys Lys Ile Thr Ser Lys Phe His Pro Ala Arg Tyr Asp Ala 
            260                 265                 270         

Lys Asn Asp Arg Met Val Pro Ile Glu Glu Asn Ile Asp Val Ile Glu 
        275                 280                 285             

Trp Val Ala Asp Pro Ala Glu Phe Ile Tyr Asn Ala Ile Ala Pro Ala 
    290                 295                 300                 

Glu Val Asp Gln Val Ile Phe Asp Glu Asn Asp Ser Lys Arg Ala Leu 
305                 310                 315                 320 

Val Val Val Pro Asp Asn Lys Leu Ser Leu Ala Ile Gly Arg Arg Gly 
                325                 330                 335     

Gln Asn Val Arg Leu Ala Ala His Leu Thr Gly Tyr Arg Ile Asp Ile 
            340                 345                 350         

Lys Ser Ala Ser Glu Phe Glu Ala Met Glu Asp Ala Ala Ser Val Glu 
        355                 360                 365             

Leu Glu Val Glu Asn Asp Thr Val Glu Glu 
    370                 375             

<210>   979
<211>   291
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   979
atgaaaacaa gaaaaatccc tttgcgcaag tctgttgtgt ctaacgaagt gattgataag   60
cgtgatttgc tccgcattgt caagaacaag gaaggacaag tctttattga tcctacgggc   120
aaggccaatg gccgcggcgc ttatatcaaa ctagacaatg cagaagccct agaggcgaaa   180
aagaagaagg tctttaaccg cagctttagc atggaagtgg aagaaagctt ttatgacgag   240
ttgatcgctt atgtggatca caaagtgaaa agaagagagt tgggacttga a            291

<210>   980
<211>   97
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902523 (9.E-51)

<400>   980
Met Lys Thr Arg Lys Ile Pro Leu Arg Lys Ser Val Val Ser Asn Glu 
1               5                   10                  15      

Val Ile Asp Lys Arg Asp Leu Leu Arg Ile Val Lys Asn Lys Glu Gly 
            20                  25                  30          

Gln Val Phe Ile Asp Pro Thr Gly Lys Ala Asn Gly Arg Gly Ala Tyr 
        35                  40                  45              

Ile Lys Leu Asp Asn Ala Glu Ala Leu Glu Ala Lys Lys Lys Lys Val 
    50                  55                  60                  

Phe Asn Arg Ser Phe Ser Met Glu Val Glu Glu Ser Phe Tyr Asp Glu 
65                  70                  75                  80  

Leu Ile Ala Tyr Val Asp His Lys Val Lys Arg Arg Glu Leu Gly Leu 
                85                  90                  95      

Glu 
    

<210>   981
<211>   297
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   981
ttgaataagc aaaagataag taatctcttg gggcttgctc agcgagcagg gcgcatcata   60
tcgggtgaag aattggtggt caaggccatt caagacggca aggccaagtt ggtctttcta   120
gctcatgatg ctggacccaa tctgaccaag aagattcaag ataaaagtca ttattatcaa   180
gtagaaattg taaccgtgtt ttcaacactg gaattaagca tagcagtcgg gaaatcgaga   240
aaggttttgg ctgtaacaga tgctggattt acaaagaaaa tgaggtctct tatggaa      297

<210>   982
<211>   99
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L7A family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902524 (3.E-49)

<400>   982
Met Asn Lys Gln Lys Ile Ser Asn Leu Leu Gly Leu Ala Gln Arg Ala 
1               5                   10                  15      

Gly Arg Ile Ile Ser Gly Glu Glu Leu Val Val Lys Ala Ile Gln Asp 
            20                  25                  30          

Gly Lys Ala Lys Leu Val Phe Leu Ala His Asp Ala Gly Pro Asn Leu 
        35                  40                  45              

Thr Lys Lys Ile Gln Asp Lys Ser His Tyr Tyr Gln Val Glu Ile Val 
    50                  55                  60                  

Thr Val Phe Ser Thr Leu Glu Leu Ser Ile Ala Val Gly Lys Ser Arg 
65                  70                  75                  80  

Lys Val Leu Ala Val Thr Asp Ala Gly Phe Thr Lys Lys Met Arg Ser 
                85                  90                  95      

Leu Met Glu 
            

<210>   983
<211>   2874
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   983
ttgtctaaga aaagattgta cgaaatcgca aaagaacttg gaaaagaaag taaagaagtt   60
gtagcgcgtg caaaagagtt gggcttggat gtgaaaagcc actcatcaag tgtggaagaa   120
gctgtcgctg caaaaattgc tgccagcttt aagcctgcag ctgctccgaa agtagaagca   180
aaacctgcag ccccaaaagt aagtgcagaa aagaaagccg aaaaatctga gccagctaaa   240
ccagctgtag ctaaggaaga ggcaaaacct gcagccccaa aagcaagtgc agaaaagaaa   300
gccgaaaagt ctgaaccagt aaaaccagct gtagccaagg aagaggcaaa accagctgag   360
ccagtcactc cgaaaacaga aaaagtagcg gctaaaccgc aaagtcgtaa tttcaaggct   420
gagcgtgaag cacgtgctaa agagcaggca gagcgacgca agcaaaataa gggcaataac   480
cgtgaccaac aacaaaacgg aaaccgtcag aaaaacgacg gccgtaatgg tggaaaacaa   540
ggtcaaagca accgcgacaa tcgtcgcttt aatgaccaag ctaagaagca gcaaggtcag   600
caaaaacgta gaaatgagcg ccgtcagcaa gaggataaac gttcaaatca agcggctcca   660
cgtattgact ttaaagcccg tgcagcagcc ctaaaagcag agcaaaatgc agagtacgct   720
cgttcaagtg aggaacgctt caagcagtat caggctgcta aagaagcctt ggctcaagct   780
aacaaacgca aggaaccaga ggaaatcttt gaagaagcgg ctaagttagc tgaacaagca   840
cagcaagttc aagcagtggt tgaagtcgtc cctgagaaaa aagaacctgc agtggataca   900
cgtcgtaaaa aacaagctcg accagacaaa aatcgtgacg attatgatca tgaagaagat   960
ggtcctagaa aacaacaaaa gaatcgaagt agtcaaaatc aagtgagaaa tcaaaagaat   1020
agtaactgga ataacaacaa aaagaacaaa aaaggcaata acaagaacaa ccgtaatcag   1080
actccaaaac ctgttacgga gcgtaaattc catgaattgc caacagaatt tgaatataca   1140
gatggtatga ccgttgcgga aatcgcaaaa cgtatcaaac gtgaaccagc tgaaattgtt   1200
aagaaacttt tcatgatggg tgtcatggcc acacaaaacc aatccttgga tggggaaaca   1260
attgaactcc tcatggtgga ttacggtatc gaagccaaac aaaaggttga agtggataat   1320
gctgacatcg aacgtttctt tgtcgaagat ggttatctca atgaagatga attggttgag   1380
cgtccaccag ttgttactat catgggacac gttgaccacg gtaaaacaac ccttttggat   1440
actcttcgta actcacgtgt tgcgacaggt gaagcaggtg gtattactca gcatatcggt   1500
gcctaccaaa tcgtggaaaa tggtaagaag attaccttcc ttgatacacc aggacacgcg   1560
gcctttacat caatgcgtgc gcgtggtgct tctgttaccg atattacgat cttggtcgta   1620
gcggcagatg acggggttat gcctcagact attgaagcca tcaaccactc aaaagcagct   1680
aacgttccaa tcatcgtagc tattaacaag attgataaac caggtgctaa cccagaacgc   1740
gttatcggtg aattggcaga gcatggtgtg atgtcaactg cttggggtgg agattctgaa   1800
tttgttgaaa tttcggctaa attcaaccaa aatatcgaag aattgttgga aacagtcctt   1860
cttgtggctg aaatccaaga actcaaagca gacccaacag ttcgtgcgat cggtacggtt   1920
atcgaagcgc gcttggataa aggaaaaggt gcggtcgcaa cccttcttgt acaacaaggt   1980
accttgaatg ttcaagaccc aatcgttgtc ggaaatacct tcggtcgtgt ccgtgctatg   2040
accaacgacc ttggtcgtcg tgttaaagtt gctggaccat caacaccagt ctctatcaca   2100
ggtttgaacg aagcaccgat ggcgggtgac cactttgccg tttacgagga tgaaaaatct   2160
gcgcgtgcag caggtgaaga gcgtgccaaa cgtgccctca tgaaacaacg tcaagctacc   2220
caacgtgtta gccttgaaaa cctctttgat acccttaaag ctggggaact caaatctgtt   2280
aatgttatca tcaaggctga tgtacaaggt tctgttgaag ccctttctgc ctcacttcaa   2340
aagattgacg tggaaggtgt caaagtgact atcgtccact cagcggtcgg tgctatcaac   2400
gaatcagacg tgacccttgc cgaagcttca aatgccttta tcgttggttt caacgtacgc   2460
cctacaccac aagctcgtca acaagcagaa gctgacgatg tggaaatccg tcttcacagc   2520
attatctaca aggttatcga agagatggaa gaagctatga aagggatgct tgatccagaa   2580
tttgaagaaa aagttattgg tgaagcggtt atccgtgaaa ccttcaaggt gtctaaagtg   2640
ggaactatcg gtggatttat ggttatcaac ggtaaggttg cccgtgactc taaagtccgt   2700
gttatccgtg atggtgtcgt tatctatgat ggtgaactcg caagcttgaa acactataaa   2760
gacgacgtga aagaagtgac aaacggtcgt gaaggtggat tgatgatcga cggctacaat   2820
gatattaaga tggatgatgt gattgaggcg tatgtcatgg aagaaatcaa gaga         2874

<210>   984
<211>   958
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   translation initiation factor IF-2 (infB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902525 (0.E+01)

<400>   984
Met Ser Lys Lys Arg Leu Tyr Glu Ile Ala Lys Glu Leu Gly Lys Glu 
1               5                   10                  15      

Ser Lys Glu Val Val Ala Arg Ala Lys Glu Leu Gly Leu Asp Val Lys 
            20                  25                  30          

Ser His Ser Ser Ser Val Glu Glu Ala Val Ala Ala Lys Ile Ala Ala 
        35                  40                  45              

Ser Phe Lys Pro Ala Ala Ala Pro Lys Val Glu Ala Lys Pro Ala Ala 
    50                  55                  60                  

Pro Lys Val Ser Ala Glu Lys Lys Ala Glu Lys Ser Glu Pro Ala Lys 
65                  70                  75                  80  

Pro Ala Val Ala Lys Glu Glu Ala Lys Pro Ala Ala Pro Lys Ala Ser 
                85                  90                  95      

Ala Glu Lys Lys Ala Glu Lys Ser Glu Pro Val Lys Pro Ala Val Ala 
            100                 105                 110         

Lys Glu Glu Ala Lys Pro Ala Glu Pro Val Thr Pro Lys Thr Glu Lys 
        115                 120                 125             

Val Ala Ala Lys Pro Gln Ser Arg Asn Phe Lys Ala Glu Arg Glu Ala 
    130                 135                 140                 

Arg Ala Lys Glu Gln Ala Glu Arg Arg Lys Gln Asn Lys Gly Asn Asn 
145                 150                 155                 160 

Arg Asp Gln Gln Gln Asn Gly Asn Arg Gln Lys Asn Asp Gly Arg Asn 
                165                 170                 175     

Gly Gly Lys Gln Gly Gln Ser Asn Arg Asp Asn Arg Arg Phe Asn Asp 
            180                 185                 190         

Gln Ala Lys Lys Gln Gln Gly Gln Gln Lys Arg Arg Asn Glu Arg Arg 
        195                 200                 205             

Gln Gln Glu Asp Lys Arg Ser Asn Gln Ala Ala Pro Arg Ile Asp Phe 
    210                 215                 220                 

Lys Ala Arg Ala Ala Ala Leu Lys Ala Glu Gln Asn Ala Glu Tyr Ala 
225                 230                 235                 240 

Arg Ser Ser Glu Glu Arg Phe Lys Gln Tyr Gln Ala Ala Lys Glu Ala 
                245                 250                 255     

Leu Ala Gln Ala Asn Lys Arg Lys Glu Pro Glu Glu Ile Phe Glu Glu 
            260                 265                 270         

Ala Ala Lys Leu Ala Glu Gln Ala Gln Gln Val Gln Ala Val Val Glu 
        275                 280                 285             

Val Val Pro Glu Lys Lys Glu Pro Ala Val Asp Thr Arg Arg Lys Lys 
    290                 295                 300                 

Gln Ala Arg Pro Asp Lys Asn Arg Asp Asp Tyr Asp His Glu Glu Asp 
305                 310                 315                 320 

Gly Pro Arg Lys Gln Gln Lys Asn Arg Ser Ser Gln Asn Gln Val Arg 
                325                 330                 335     

Asn Gln Lys Asn Ser Asn Trp Asn Asn Asn Lys Lys Asn Lys Lys Gly 
            340                 345                 350         

Asn Asn Lys Asn Asn Arg Asn Gln Thr Pro Lys Pro Val Thr Glu Arg 
        355                 360                 365             

Lys Phe His Glu Leu Pro Thr Glu Phe Glu Tyr Thr Asp Gly Met Thr 
    370                 375                 380                 

Val Ala Glu Ile Ala Lys Arg Ile Lys Arg Glu Pro Ala Glu Ile Val 
385                 390                 395                 400 

Lys Lys Leu Phe Met Met Gly Val Met Ala Thr Gln Asn Gln Ser Leu 
                405                 410                 415     

Asp Gly Glu Thr Ile Glu Leu Leu Met Val Asp Tyr Gly Ile Glu Ala 
            420                 425                 430         

Lys Gln Lys Val Glu Val Asp Asn Ala Asp Ile Glu Arg Phe Phe Val 
        435                 440                 445             

Glu Asp Gly Tyr Leu Asn Glu Asp Glu Leu Val Glu Arg Pro Pro Val 
    450                 455                 460                 

Val Thr Ile Met Gly His Val Asp His Gly Lys Thr Thr Leu Leu Asp 
465                 470                 475                 480 

Thr Leu Arg Asn Ser Arg Val Ala Thr Gly Glu Ala Gly Gly Ile Thr 
                485                 490                 495     

Gln His Ile Gly Ala Tyr Gln Ile Val Glu Asn Gly Lys Lys Ile Thr 
            500                 505                 510         

Phe Leu Asp Thr Pro Gly His Ala Ala Phe Thr Ser Met Arg Ala Arg 
        515                 520                 525             

Gly Ala Ser Val Thr Asp Ile Thr Ile Leu Val Val Ala Ala Asp Asp 
    530                 535                 540                 

Gly Val Met Pro Gln Thr Ile Glu Ala Ile Asn His Ser Lys Ala Ala 
545                 550                 555                 560 

Asn Val Pro Ile Ile Val Ala Ile Asn Lys Ile Asp Lys Pro Gly Ala 
                565                 570                 575     

Asn Pro Glu Arg Val Ile Gly Glu Leu Ala Glu His Gly Val Met Ser 
            580                 585                 590         

Thr Ala Trp Gly Gly Asp Ser Glu Phe Val Glu Ile Ser Ala Lys Phe 
        595                 600                 605             

Asn Gln Asn Ile Glu Glu Leu Leu Glu Thr Val Leu Leu Val Ala Glu 
    610                 615                 620                 

Ile Gln Glu Leu Lys Ala Asp Pro Thr Val Arg Ala Ile Gly Thr Val 
625                 630                 635                 640 

Ile Glu Ala Arg Leu Asp Lys Gly Lys Gly Ala Val Ala Thr Leu Leu 
                645                 650                 655     

Val Gln Gln Gly Thr Leu Asn Val Gln Asp Pro Ile Val Val Gly Asn 
            660                 665                 670         

Thr Phe Gly Arg Val Arg Ala Met Thr Asn Asp Leu Gly Arg Arg Val 
        675                 680                 685             

Lys Val Ala Gly Pro Ser Thr Pro Val Ser Ile Thr Gly Leu Asn Glu 
    690                 695                 700                 

Ala Pro Met Ala Gly Asp His Phe Ala Val Tyr Glu Asp Glu Lys Ser 
705                 710                 715                 720 

Ala Arg Ala Ala Gly Glu Glu Arg Ala Lys Arg Ala Leu Met Lys Gln 
                725                 730                 735     

Arg Gln Ala Thr Gln Arg Val Ser Leu Glu Asn Leu Phe Asp Thr Leu 
            740                 745                 750         

Lys Ala Gly Glu Leu Lys Ser Val Asn Val Ile Ile Lys Ala Asp Val 
        755                 760                 765             

Gln Gly Ser Val Glu Ala Leu Ser Ala Ser Leu Gln Lys Ile Asp Val 
    770                 775                 780                 

Glu Gly Val Lys Val Thr Ile Val His Ser Ala Val Gly Ala Ile Asn 
785                 790                 795                 800 

Glu Ser Asp Val Thr Leu Ala Glu Ala Ser Asn Ala Phe Ile Val Gly 
                805                 810                 815     

Phe Asn Val Arg Pro Thr Pro Gln Ala Arg Gln Gln Ala Glu Ala Asp 
            820                 825                 830         

Asp Val Glu Ile Arg Leu His Ser Ile Ile Tyr Lys Val Ile Glu Glu 
        835                 840                 845             

Met Glu Glu Ala Met Lys Gly Met Leu Asp Pro Glu Phe Glu Glu Lys 
    850                 855                 860                 

Val Ile Gly Glu Ala Val Ile Arg Glu Thr Phe Lys Val Ser Lys Val 
865                 870                 875                 880 

Gly Thr Ile Gly Gly Phe Met Val Ile Asn Gly Lys Val Ala Arg Asp 
                885                 890                 895     

Ser Lys Val Arg Val Ile Arg Asp Gly Val Val Ile Tyr Asp Gly Glu 
            900                 905                 910         

Leu Ala Ser Leu Lys His Tyr Lys Asp Asp Val Lys Glu Val Thr Asn 
        915                 920                 925             

Gly Arg Glu Gly Gly Leu Met Ile Asp Gly Tyr Asn Asp Ile Lys Met 
    930                 935                 940                 

Asp Asp Val Ile Glu Ala Tyr Val Met Glu Glu Ile Lys Arg 
945                 950                 955             

<210>   985
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   985
ttggacacgt ggatcacgga ctttcttttg caaaatctca ttgacttcac gcttgatttc   60
catgcccaca cgatctgtac ggaaatgatt tgccatgata ttcctttctc tactttgaac   120
caaaagctag gccagcagac c                                             141

<210>   986
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   986
Met Asp Thr Trp Ile Thr Asp Phe Leu Leu Gln Asn Leu Ile Asp Phe 
1               5                   10                  15      

Thr Leu Asp Phe His Ala His Thr Ile Cys Thr Glu Met Ile Cys His 
            20                  25                  30          

Asp Ile Pro Phe Ser Thr Leu Asn Gln Lys Leu Gly Gln Gln Thr 
        35                  40                  45          

<210>   987
<211>   348
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   987
atggcaaatc atttccgtac agatcgtgtg ggcatggaaa tcaagcgtga agtcaatgag   60
attttgcaaa agaaagtccg tgatccacgt gtccaaggtg tgaccatcat agatgttcag   120
atgctgggtg acttgtctgt tgccaaggtt tattacacca ttttgagtaa ccttgcttcg   180
gataaccaaa aagcccaaat cgggcttgaa aaagcaactg gtaccatcaa acgtgaactt   240
ggtcgcaatt tgaaattgta caaaatccca gatttgacct tcgtcaaaga cgagtccatc   300
gagtatggaa acaagattga cgagatgcta cgcaatctgg ataagaac                348

<210>   988
<211>   116
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosome-binding factor A (rbfA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902526 (4.E-60)

<400>   988
Met Ala Asn His Phe Arg Thr Asp Arg Val Gly Met Glu Ile Lys Arg 
1               5                   10                  15      

Glu Val Asn Glu Ile Leu Gln Lys Lys Val Arg Asp Pro Arg Val Gln 
            20                  25                  30          

Gly Val Thr Ile Ile Asp Val Gln Met Leu Gly Asp Leu Ser Val Ala 
        35                  40                  45              

Lys Val Tyr Tyr Thr Ile Leu Ser Asn Leu Ala Ser Asp Asn Gln Lys 
    50                  55                  60                  

Ala Gln Ile Gly Leu Glu Lys Ala Thr Gly Thr Ile Lys Arg Glu Leu 
65                  70                  75                  80  

Gly Arg Asn Leu Lys Leu Tyr Lys Ile Pro Asp Leu Thr Phe Val Lys 
                85                  90                  95      

Asp Glu Ser Ile Glu Tyr Gly Asn Lys Ile Asp Glu Met Leu Arg Asn 
            100                 105                 110         

Leu Asp Lys Asn 
        115     

<210>   989
<211>   813
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   989
atgataaggt gcaaaaaaga aataaggagt ttgtatatgg ctgaacaaga cttagctatg   60
caagtattgc aacaagtggt gaaactacct gttgttaagg ttgatcgttc gaaattttta   120
gtggataagt tttccaaaga attggatcca aaagatattc ctaccttatt ggaacaaggt   180
ccaacgactc ttctatctca agaaatatta gatcgtgtag ctaatgcttg tattcgggac   240
aatgtattat tagcgagtgg gacttctgtt ttggcaggat tacctggagg gcttgctatg   300
gcaattacca ttccagctga tgtggctcaa ttttatgctt tctctctgaa attggctcaa   360
gaattaggtt atatttatgg ttatgaggat ctttgggctt cacgagagga gttgagtgaa   420
gatgctcaaa ataccctctt gctttatcta ggcgtaatgt taggggtgaa tggaaccgct   480
gctttgctac gtgttggtag tataacaatt gccaaacagg taatgaaaat agtgcctaat   540
aaagctttaa caaagacgct ttggtaccct attttgaaaa aagtcttaaa aatatttggt   600
gtgaatctta ccaagggagg gttggccaaa ggaatgggga aatttattcc tatcttgggt   660
ggtatcattt caggtggttt aacctttgca actatgaaac caatggggga aagcttgcag   720
aaagaattat ccaagctagt caactatagt gaagttcaat atcaagaaga tgttgaaaca   780
atccgaaaag aggctgaaat catcaaagga gag                                813

<210>   990
<211>   271
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902527 (e-148)

<400>   990
Met Ile Arg Cys Lys Lys Glu Ile Arg Ser Leu Tyr Met Ala Glu Gln 
1               5                   10                  15      

Asp Leu Ala Met Gln Val Leu Gln Gln Val Val Lys Leu Pro Val Val 
            20                  25                  30          

Lys Val Asp Arg Ser Lys Phe Leu Val Asp Lys Phe Ser Lys Glu Leu 
        35                  40                  45              

Asp Pro Lys Asp Ile Pro Thr Leu Leu Glu Gln Gly Pro Thr Thr Leu 
    50                  55                  60                  

Leu Ser Gln Glu Ile Leu Asp Arg Val Ala Asn Ala Cys Ile Arg Asp 
65                  70                  75                  80  

Asn Val Leu Leu Ala Ser Gly Thr Ser Val Leu Ala Gly Leu Pro Gly 
                85                  90                  95      

Gly Leu Ala Met Ala Ile Thr Ile Pro Ala Asp Val Ala Gln Phe Tyr 
            100                 105                 110         

Ala Phe Ser Leu Lys Leu Ala Gln Glu Leu Gly Tyr Ile Tyr Gly Tyr 
        115                 120                 125             

Glu Asp Leu Trp Ala Ser Arg Glu Glu Leu Ser Glu Asp Ala Gln Asn 
    130                 135                 140                 

Thr Leu Leu Leu Tyr Leu Gly Val Met Leu Gly Val Asn Gly Thr Ala 
145                 150                 155                 160 

Ala Leu Leu Arg Val Gly Ser Ile Thr Ile Ala Lys Gln Val Met Lys 
                165                 170                 175     

Ile Val Pro Asn Lys Ala Leu Thr Lys Thr Leu Trp Tyr Pro Ile Leu 
            180                 185                 190         

Lys Lys Val Leu Lys Ile Phe Gly Val Asn Leu Thr Lys Gly Gly Leu 
        195                 200                 205             

Ala Lys Gly Met Gly Lys Phe Ile Pro Ile Leu Gly Gly Ile Ile Ser 
    210                 215                 220                 

Gly Gly Leu Thr Phe Ala Thr Met Lys Pro Met Gly Glu Ser Leu Gln 
225                 230                 235                 240 

Lys Glu Leu Ser Lys Leu Val Asn Tyr Ser Glu Val Gln Tyr Gln Glu 
                245                 250                 255     

Asp Val Glu Thr Ile Arg Lys Glu Ala Glu Ile Ile Lys Gly Glu 
            260                 265                 270     

<210>   991
<211>   180
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   991
atgaatccta tcaaagcttt tgctaaaatt tatggtaatt actttttgac cgtgcaaggt   60
gtaaaagtga tgaaaacgat aaagaaagct gaccatgtcg ttgttggtct ggggaaactt   120
tttattgccg acaagttaat ggatacggct cggtggctca ttaagccaga ggagagagaa   180

<210>   992
<211>   60
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902528 (9.E-26)

<400>   992
Met Asn Pro Ile Lys Ala Phe Ala Lys Ile Tyr Gly Asn Tyr Phe Leu 
1               5                   10                  15      

Thr Val Gln Gly Val Lys Val Met Lys Thr Ile Lys Lys Ala Asp His 
            20                  25                  30          

Val Val Val Gly Leu Gly Lys Leu Phe Ile Ala Asp Lys Leu Met Asp 
        35                  40                  45              

Thr Ala Arg Trp Leu Ile Lys Pro Glu Glu Arg Glu 
    50                  55                  60  

<210>   993
<211>   231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   993
gtggagttcc tgctagttct ctgcaacttg gattaccatc tagataagtt taaagagcca   60
atccaatatc ttaaacacta tcttgtaaaa cagcaattgg actgcaaaag agatgatcat   120
ccaaaagaat ttcacaatcc caataatcgg tttgataaaa agaatagcaa gaagaccaaa   180
aaaatttcat tctctctcct ctggcttaat gagccaccga gccgtatcca t            231

<210>   994
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   994
Met Glu Phe Leu Leu Val Leu Cys Asn Leu Asp Tyr His Leu Asp Lys 
1               5                   10                  15      

Phe Lys Glu Pro Ile Gln Tyr Leu Lys His Tyr Leu Val Lys Gln Gln 
            20                  25                  30          

Leu Asp Cys Lys Arg Asp Asp His Pro Lys Glu Phe His Asn Pro Asn 
        35                  40                  45              

Asn Arg Phe Asp Lys Lys Asn Ser Lys Lys Thr Lys Lys Ile Ser Phe 
    50                  55                  60                  

Ser Leu Leu Trp Leu Asn Glu Pro Pro Ser Arg Ile His 
65                  70                  75          

<210>   995
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   995
atgaaaatca aagagcaaac taggaagcta gccgcaggtt gctcaaaaca gtgttttgag   60
gttgtagata gaactgacga agtcagctca aaacaccgtt ttgaggttgt ggatagaact   120
gacgaagtca gtaacatata tactgcaagg                                    150

<210>   996
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   996
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

Gln Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Arg Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Asn Ile Tyr Thr 
        35                  40                  45              

Ala Arg 
    50  

<210>   997
<211>   243
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   997
atggaggtcg tcatggacaa tatcatcgat gtgtcaattc ctgttgcaga agtggtggac   60
aagcatccag aagtcttgga aattctagtg gagttgggtt ttaaacccct tgccaatccc   120
ttaatgcgca atacagttgg tcgtaaagta tcacttaaac agggttctaa gctagcagga   180
actcctatgg acaagattgt acgcacactg gaagcgaatg gctacgaagt gattggatta   240
gac                                                                 243

<210>   998
<211>   81

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902529 (2.E-41)

<400>   998
Met Glu Val Val Met Asp Asn Ile Ile Asp Val Ser Ile Pro Val Ala 
1               5                   10                  15      

Glu Val Val Asp Lys His Pro Glu Val Leu Glu Ile Leu Val Glu Leu 
            20                  25                  30          

Gly Phe Lys Pro Leu Ala Asn Pro Leu Met Arg Asn Thr Val Gly Arg 
        35                  40                  45              

Lys Val Ser Leu Lys Gln Gly Ser Lys Leu Ala Gly Thr Pro Met Asp 
    50                  55                  60                  

Lys Ile Val Arg Thr Leu Glu Ala Asn Gly Tyr Glu Val Ile Gly Leu 
65                  70                  75                  80  

Asp 
    

<210>   999
<211>   1332
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   999
atgacagatg aacggattca tatcctacgg gatattttgt tagaattgca caatggcgcc   60
tctcctgagt cggttcaaga tcgctttgat gcgaccttta cgggcgtgtc agccatcgag   120
atttccctta tggagcacga gctgatgaac tcggattcgg gcgtcacttt tgaagatgtt   180
atggaactct gtgatgtcca tgccaatctt tttaaaaatg ctatcaaagg tgtcgaagtt   240
tcagatactg agcatccagg tcacccagtt cgtgtcttca aagaagaaaa tctggctctc   300
cgtgcggcct tgattcgcat tcgtagattg ttagatacct atgagtctat ggaagacgag   360
gaaatgctgg cggagatgcg taagggtttg gtgcgtcaga tgggacttgt gggtcaattt   420
gacatccatt accaacgtaa ggaagaactc ttctttccta tcatggagcg ctatggacac   480
gattcacctc ccaaagttat gtggggagtg gatgatcaga ttagggaact ctttcaaaca   540
gctctaacga cagccaagtc actaccagaa gtgtcaatta gcagtgtaaa ggaagctttt   600
gaagcttttg cgacagagtt tgaaagtatg attttcaagg aagagtccat cctcctcatg   660
attctccttg agtcttttac tcaggatgac tggcttcaga ttgcggagga gagcgatgcc   720
tatggctatg ccatcatccg tccgtcagag aaatgggtgc cagaacgaca gagctttatt   780
gaggaaaaga ttgcagagga gcctgtacag ctagatacgg cagaaggtca agttcaacaa   840
gtcatagata cgccagaagg ccattttacc attaccttta cccctaagga aaaggaagct   900
gtgctggacc gccatagtca acaggctttt ggtaatggct atctttcagt cgagcaggcc   960
aatctcatcc tcaatcatct ccctatggag attacctttg tcaataaaga agatattttc   1020
cagtattaca atgacaatac gccagctgat gagatgattt tcaaacggac gccgtcccaa   1080
gtcgggcgca atgtcgaact ctgccatccg cctaagtact tggacaaggt caaaactatc   1140
atgaaggggc ttcgtgaggg aagcaaagac aagtatgaaa tgtggttcaa gtctgagtcg   1200
cgaggtaagt ttgtccacat cacctatgct gcagtacacg atgaagacgg agaattccaa   1260
ggagtgttgg agtatgttca ggatatccag ccctaccgtg agattgatac ggactatttt   1320
cgtggattag aa                                                       1332

<210>   1000
<211>   444
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902530 (0.E+01)

<400>   1000
Met Thr Asp Glu Arg Ile His Ile Leu Arg Asp Ile Leu Leu Glu Leu 
1               5                   10                  15      

His Asn Gly Ala Ser Pro Glu Ser Val Gln Asp Arg Phe Asp Ala Thr 
            20                  25                  30          

Phe Thr Gly Val Ser Ala Ile Glu Ile Ser Leu Met Glu His Glu Leu 
        35                  40                  45              

Met Asn Ser Asp Ser Gly Val Thr Phe Glu Asp Val Met Glu Leu Cys 
    50                  55                  60                  

Asp Val His Ala Asn Leu Phe Lys Asn Ala Ile Lys Gly Val Glu Val 
65                  70                  75                  80  

Ser Asp Thr Glu His Pro Gly His Pro Val Arg Val Phe Lys Glu Glu 
                85                  90                  95      

Asn Leu Ala Leu Arg Ala Ala Leu Ile Arg Ile Arg Arg Leu Leu Asp 
            100                 105                 110         

Thr Tyr Glu Ser Met Glu Asp Glu Glu Met Leu Ala Glu Met Arg Lys 
        115                 120                 125             

Gly Leu Val Arg Gln Met Gly Leu Val Gly Gln Phe Asp Ile His Tyr 
    130                 135                 140                 

Gln Arg Lys Glu Glu Leu Phe Phe Pro Ile Met Glu Arg Tyr Gly His 
145                 150                 155                 160 

Asp Ser Pro Pro Lys Val Met Trp Gly Val Asp Asp Gln Ile Arg Glu 
                165                 170                 175     

Leu Phe Gln Thr Ala Leu Thr Thr Ala Lys Ser Leu Pro Glu Val Ser 
            180                 185                 190         

Ile Ser Ser Val Lys Glu Ala Phe Glu Ala Phe Ala Thr Glu Phe Glu 
        195                 200                 205             

Ser Met Ile Phe Lys Glu Glu Ser Ile Leu Leu Met Ile Leu Leu Glu 
    210                 215                 220                 

Ser Phe Thr Gln Asp Asp Trp Leu Gln Ile Ala Glu Glu Ser Asp Ala 
225                 230                 235                 240 

Tyr Gly Tyr Ala Ile Ile Arg Pro Ser Glu Lys Trp Val Pro Glu Arg 
                245                 250                 255     

Gln Ser Phe Ile Glu Glu Lys Ile Ala Glu Glu Pro Val Gln Leu Asp 
            260                 265                 270         

Thr Ala Glu Gly Gln Val Gln Gln Val Ile Asp Thr Pro Glu Gly His 
        275                 280                 285             

Phe Thr Ile Thr Phe Thr Pro Lys Glu Lys Glu Ala Val Leu Asp Arg 
    290                 295                 300                 

His Ser Gln Gln Ala Phe Gly Asn Gly Tyr Leu Ser Val Glu Gln Ala 
305                 310                 315                 320 

Asn Leu Ile Leu Asn His Leu Pro Met Glu Ile Thr Phe Val Asn Lys 
                325                 330                 335     

Glu Asp Ile Phe Gln Tyr Tyr Asn Asp Asn Thr Pro Ala Asp Glu Met 
            340                 345                 350         

Ile Phe Lys Arg Thr Pro Ser Gln Val Gly Arg Asn Val Glu Leu Cys 
        355                 360                 365             

His Pro Pro Lys Tyr Leu Asp Lys Val Lys Thr Ile Met Lys Gly Leu 
    370                 375                 380                 

Arg Glu Gly Ser Lys Asp Lys Tyr Glu Met Trp Phe Lys Ser Glu Ser 
385                 390                 395                 400 

Arg Gly Lys Phe Val His Ile Thr Tyr Ala Ala Val His Asp Glu Asp 
                405                 410                 415     

Gly Glu Phe Gln Gly Val Leu Glu Tyr Val Gln Asp Ile Gln Pro Tyr 
            420                 425                 430         

Arg Glu Ile Asp Thr Asp Tyr Phe Arg Gly Leu Glu 
        435                 440                 

<210>   1001
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1001
atgagttacg aacaagaatt tatgaaggaa tttgaagctt gggtcaatac ccaaatcatg   60
attaacgaca tggcgcacaa ggaaagccaa aaagtttacg aagaagacca ggacgagcgt   120
gccaaagatg ccatgattcg ctacgagagt cgcttggatg cttatcagtt cttgcttggt   180
aagtttgaaa acttcaaagt aggcaaggga ttccatgatt tgccagaagg cttgtttggt   240
gagcgaaatt at                                                       252

<210>   1002
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902531 (4.E-46)

<400>   1002
Met Ser Tyr Glu Gln Glu Phe Met Lys Glu Phe Glu Ala Trp Val Asn 
1               5                   10                  15      

Thr Gln Ile Met Ile Asn Asp Met Ala His Lys Glu Ser Gln Lys Val 
            20                  25                  30          

Tyr Glu Glu Asp Gln Asp Glu Arg Ala Lys Asp Ala Met Ile Arg Tyr 
        35                  40                  45              

Glu Ser Arg Leu Asp Ala Tyr Gln Phe Leu Leu Gly Lys Phe Glu Asn 
    50                  55                  60                  

Phe Lys Val Gly Lys Gly Phe His Asp Leu Pro Glu Gly Leu Phe Gly 
65                  70                  75                  80  

Glu Arg Asn Tyr 
                

<210>   1003
<211>   393
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1003
atgtcaaaga aactcaatcg taaaaaacaa ttacgaaatg gcctccgtcg cgcaggtgcc   60
ttttcaagta cggtgactaa ggttgtagat gagacaaaaa aagtcgtgaa gcgtgcagaa   120
cagtcagcaa gcgcagctgg taaggctgtt tctaaaaaag ttgaacaagc agtagaagct   180
accaaagagc aagctcaaaa agtagctaat tctgtagaag attttgcagc aaatttgggt   240
ggacttccac ttgatcgtgc caagactttc tatgatgaag gaatcaagtc tgcttcagat   300
ttcaaaaact ggactgaaaa agaactcctt gccttgaaag gaatcggccc agctaccatc   360
aagaaattga aagaaaatgg catcaagttc aag                                393

<210>   1004
<211>   131
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902532 (7.E-68)

<400>   1004
Met Ser Lys Lys Leu Asn Arg Lys Lys Gln Leu Arg Asn Gly Leu Arg 
1               5                   10                  15      

Arg Ala Gly Ala Phe Ser Ser Thr Val Thr Lys Val Val Asp Glu Thr 
            20                  25                  30          

Lys Lys Val Val Lys Arg Ala Glu Gln Ser Ala Ser Ala Ala Gly Lys 
        35                  40                  45              

Ala Val Ser Lys Lys Val Glu Gln Ala Val Glu Ala Thr Lys Glu Gln 
    50                  55                  60                  

Ala Gln Lys Val Ala Asn Ser Val Glu Asp Phe Ala Ala Asn Leu Gly 
65                  70                  75                  80  

Gly Leu Pro Leu Asp Arg Ala Lys Thr Phe Tyr Asp Glu Gly Ile Lys 
                85                  90                  95      

Ser Ala Ser Asp Phe Lys Asn Trp Thr Glu Lys Glu Leu Leu Ala Leu 
            100                 105                 110         

Lys Gly Ile Gly Pro Ala Thr Ile Lys Lys Leu Lys Glu Asn Gly Ile 
        115                 120                 125             

Lys Phe Lys 
    130     

<210>   1005
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1005
gtgattggag tcgttgcgag agagaatgcc gcagagcaga tcaaacagta tcaaaaattt   60
actgtgaata tttctgatga aacttctatg cttgcgatgg agcaggctgg ttttatcagt   120
catcaggaga aattggaacg tttgggagtg cattatgaaa tttctgaacg aactcagact   180
cctattttag acgcctgtcc acttgtttta gattgtcggg tagataggat tgttgaggaa   240
gacggtattt gccacatctt tgccaagatt cttgagcgac ttgttgcccc agaactcctg   300
gatgaaaagg gacattttaa aaatcaactg tttgccccaa cctatttcat gggagatgga   360
tatcagcgcg tttatcgcta tctggacaag cgtgtagata tgaagggcag tttcatcaaa   420
aaagcgagga agaaggatgg caagaac                                       447

<210>   1006
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902533 (5.E-83)

<400>   1006
Met Ile Gly Val Val Ala Arg Glu Asn Ala Ala Glu Gln Ile Lys Gln 
1               5                   10                  15      

Tyr Gln Lys Phe Thr Val Asn Ile Ser Asp Glu Thr Ser Met Leu Ala 
            20                  25                  30          

Met Glu Gln Ala Gly Phe Ile Ser His Gln Glu Lys Leu Glu Arg Leu 
        35                  40                  45              

Gly Val His Tyr Glu Ile Ser Glu Arg Thr Gln Thr Pro Ile Leu Asp 
    50                  55                  60                  

Ala Cys Pro Leu Val Leu Asp Cys Arg Val Asp Arg Ile Val Glu Glu 
65                  70                  75                  80  

Asp Gly Ile Cys His Ile Phe Ala Lys Ile Leu Glu Arg Leu Val Ala 
                85                  90                  95      

Pro Glu Leu Leu Asp Glu Lys Gly His Phe Lys Asn Gln Leu Phe Ala 
            100                 105                 110         

Pro Thr Tyr Phe Met Gly Asp Gly Tyr Gln Arg Val Tyr Arg Tyr Leu 
        115                 120                 125             

Asp Lys Arg Val Asp Met Lys Gly Ser Phe Ile Lys Lys Ala Arg Lys 
    130                 135                 140                 

Lys Asp Gly Lys Asn 
145                 

<210>   1007
<211>   558
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1007
atggcaagaa ctgagctgcc agataaaatc gaaacagaac gtctcgtttt acgagtccgc   60
acagtggtgg atgctgagga tatccatacc tacgctagtt tgccagaggt cgcctatcca   120
gcaggttttc ctccagtcaa gatcttggaa gatgagattt attatctgga gcacattctt   180
ccggagcgta ctcaaaagga aaatctccca gctggctatg ggattgtcgt caaaggaacc   240
gataaagtca ttggttctgt tgacttcaac catcttcatg cggatgatgt gctagagctt   300
ggctatacct tgcacccaga ctattggggt cgaggttatg ttccagaagc agcgtgttcc   360
ttgattgatc tagcttttaa agaacttggt cttcacaaga ttgaactaac ttgctttgga   420
tataaccttc aaagtcaacg agtctcggaa aagcttggct ttaccctcga agctcgcata   480
agagaccgca aagatgctca aggcaactgc tgtgatgatt tgagatatgg cttgctgagg   540
agtgagtggg aggtgatt                                                 558

<210>   1008
<211>   186
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902534 (1.E-95)

<400>   1008
Met Ala Arg Thr Glu Leu Pro Asp Lys Ile Glu Thr Glu Arg Leu Val 
1               5                   10                  15      

Leu Arg Val Arg Thr Val Val Asp Ala Glu Asp Ile His Thr Tyr Ala 
            20                  25                  30          

Ser Leu Pro Glu Val Ala Tyr Pro Ala Gly Phe Pro Pro Val Lys Ile 
        35                  40                  45              

Leu Glu Asp Glu Ile Tyr Tyr Leu Glu His Ile Leu Pro Glu Arg Thr 
    50                  55                  60                  

Gln Lys Glu Asn Leu Pro Ala Gly Tyr Gly Ile Val Val Lys Gly Thr 
65                  70                  75                  80  

Asp Lys Val Ile Gly Ser Val Asp Phe Asn His Leu His Ala Asp Asp 
                85                  90                  95      

Val Leu Glu Leu Gly Tyr Thr Leu His Pro Asp Tyr Trp Gly Arg Gly 
            100                 105                 110         

Tyr Val Pro Glu Ala Ala Cys Ser Leu Ile Asp Leu Ala Phe Lys Glu 
        115                 120                 125             

Leu Gly Leu His Lys Ile Glu Leu Thr Cys Phe Gly Tyr Asn Leu Gln 
    130                 135                 140                 

Ser Gln Arg Val Ser Glu Lys Leu Gly Phe Thr Leu Glu Ala Arg Ile 
145                 150                 155                 160 

Arg Asp Arg Lys Asp Ala Gln Gly Asn Cys Cys Asp Asp Leu Arg Tyr 
                165                 170                 175     

Gly Leu Leu Arg Ser Glu Trp Glu Val Ile 
            180                 185     

<210>   1009
<211>   591
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1009
gtgggaggtg atttgatgca tcttttcatc attggtgctc cagcatcagg aaaaatgacc   60
attggtcaag aattatctcg actgacggat gctaccctat tttataacca tcaagccatt   120
gattttgcac tagagatcta tcaggattat accgaggaga tgtgggaatt tgttcgtgga   180
attacctttt ctttccttgg agcaagtgca agaaatcagc gatcagtaat tttaacagac   240
gtaattgatt tttcaaatca gtaccagctg atgtatttaa agcaaattca ggatttattg   300
gataactttc atcaagagat tctgtttgtt gaattggaaa caagtcttga agagtgcata   360
cgtcgaaatc gaacggagaa tcgattaaag cacaaaccct taaaacgaca tattgaggta   420
tctgaaagag aaattttaga gaccgctgaa acacttcaat taaattccca acatcaaccg   480
aatgagttgc accactactt taaaataaat aatacgaatt tgtctgcaga agaagctgct   540
aagcaaattc aaaataaaat aaacaaaata gagaaaggac acacacatgt c            591

<210>   1010
<211>   197
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm

<400>   1010
Met Gly Gly Asp Leu Met His Leu Phe Ile Ile Gly Ala Pro Ala Ser 
1               5                   10                  15      

Gly Lys Met Thr Ile Gly Gln Glu Leu Ser Arg Leu Thr Asp Ala Thr 
            20                  25                  30          

Leu Phe Tyr Asn His Gln Ala Ile Asp Phe Ala Leu Glu Ile Tyr Gln 
        35                  40                  45              

Asp Tyr Thr Glu Glu Met Trp Glu Phe Val Arg Gly Ile Thr Phe Ser 
    50                  55                  60                  

Phe Leu Gly Ala Ser Ala Arg Asn Gln Arg Ser Val Ile Leu Thr Asp 
65                  70                  75                  80  

Val Ile Asp Phe Ser Asn Gln Tyr Gln Leu Met Tyr Leu Lys Gln Ile 
                85                  90                  95      

Gln Asp Leu Leu Asp Asn Phe His Gln Glu Ile Leu Phe Val Glu Leu 
            100                 105                 110         

Glu Thr Ser Leu Glu Glu Cys Ile Arg Arg Asn Arg Thr Glu Asn Arg 
        115                 120                 125             

Leu Lys His Lys Pro Leu Lys Arg His Ile Glu Val Ser Glu Arg Glu 
    130                 135                 140                 

Ile Leu Glu Thr Ala Glu Thr Leu Gln Leu Asn Ser Gln His Gln Pro 
145                 150                 155                 160 

Asn Glu Leu His His Tyr Phe Lys Ile Asn Asn Thr Asn Leu Ser Ala 
                165                 170                 175     

Glu Glu Ala Ala Lys Gln Ile Gln Asn Lys Ile Asn Lys Ile Glu Lys 
            180                 185                 190         

Gly His Thr His Val 
        195         

<210>   1011
<211>   2649
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1011
atgtctaaag aactttcacc taaatacaat ccagccgagg ttgaggctgg tcgttaccaa   60
aaatggcttg atgcggatgt tttcaagcct tcaggcgatc aaaaggctaa gccttattca   120
atcgtgattc caccaccaaa cgtaactggg aaacttcacc ttggtcacgc ttgggatacg   180
actttgcagg atatcatcat ccgtcaaaaa cgcatgcaag gctttgatac cctttggctt   240
ccaggtatgg accacgctgg tattgcgact caggctaagg ttgaggagcg cttacgtggt   300
gagggtatta cgcgttatga cctaggtcgt gagtctttct tgacgaaggt ctgggaatgg   360
aaagacgaat atgccactac catcaaggaa caatggggca agatggggct ttctgtagac   420
tattctcgtg agcgtttcac tcttgatgaa ggtttgtcaa aagctgttcg taaggtcttt   480
gtgaaccttt acaagaaagg ctggatctat cgtggtgagt ttatcatcaa ctgggaccca   540
gcagctcgca cagccctttc tgatattgag gtgattcaca aggatgtaga aggtgccttc   600
taccacatga attacatgct ggaagatggt tcacgcgccc ttgaagttgc tacaactcgt   660
cctgagacta tgtttgggga cgttgcggtt gcggttaatc cagaagaccc gcgctacaag   720
gacttgattg gtaaaaacgt catccttcca atcgctaata aactcatccc aatcgttgga   780
gatgagcacg cagatcctga gcttggtact ggtgtcgtga aaatcacacc tgcccacgat   840
ccaaatgact tcttggttgg ccaacgtcat aacttgccac aagtcaacgt catgaacgac   900
gacggaacta tgaatgagct tgcctttgaa ttttcaggca tggatcgttt tgaagctcgt   960
aaggcagtcg ttgctaagtt ggaagaaatc ggtgcccttg tcaaaatcga aaaacgtgtc   1020
cacagtgttg gtcactcaga acgtacaggt gtcgtagttg agccacgctt gtctactcaa   1080
tggttcgtca agatggacca attggctaag aacgccattg ctaaccaaga cacagaggac   1140
aaggtcgaat tctacccacc tcgtttcaac gataccttcc ttcaatggat ggaaaatgtc   1200
cacgactggg ttatctctcg tcagctttgg tggggtcacc aaatccctgc ctggtacaat   1260
gctgatggtg aaatgtatgt cggcgaagaa gctccagaag gtgacggatg gactcaggac   1320
gaagacgtct tggatacttg gttcagttct gccctctggc cattttcaac catgggctgg   1380
cctgaagtcg actcagaaga ctttaaacgt tatttcccaa cttcaacctt ggtaacaggt   1440
tacgacatca tcttcttctg ggtgtctcgt atgatcttcc agtccttgga atttactggt   1500
cgtcagccat tccaaaacgt gcttatccac ggtctcatcc gtgacgagca aggacgcaag   1560
atgtctaaat ctctcggtaa cgggattgac ccaatggatg tcatcgagaa atacggtgct   1620
gatgcccttc gttggttcct ttcaaacggt tccgcaccag gtcaagacgt tcgtttctct   1680
tacgagaaaa tggatgcttc atggaacttt attaacaaaa tttggaacat ttctcgctat   1740
atcctcatga acaatgaagg tttgacgctg gatgtggcgc atgacaatgt cacaaaagtt   1800
gcaacaggtg aggctggtaa tgtgacggac cgctggattc tccacaatct caacgaaacc   1860
attgcaaaag ttactgaaaa ctttgataag ttcgagtttg gtgtggctgg tcatatcctt   1920
tacaacttca tctgggaaga atttgccaac tggtatgttg agttgaccaa ggaagttcta   1980
tacagcgaca atgaagacga taaggtcatt actcgatctg ttctcctcta tacgctggac   2040
aagatccttc gtctccttca cccaatcatg ccattcgtga cagaggaaat ctttggacaa   2100
atctcagaag gttctatcgt gacagctgca tacccaactg ttaatctagc ctttgaagac   2160
cttgcggctc acactggtgt ggaaagtctc aaagacttga ttcgtgctgt tcggaatgcg   2220
cgtgcggaag taaatgtagc accaagcaag cctatcacca tccttgttaa gacaagcgat   2280
agcgacttgg aagccttctt taacagcaat gtcaactata tcaaacgctt tacaaatcca   2340
gaacacttgg aaatcgcatc aaccatccct gcacctgaac tggctatgtc aagtgtcatc   2400
acaggagcag aaatctacct gccactggcc gatctcctca atgttgaaga agaactggcc   2460
cgtctcgaca aggaacttgc taaatggcaa aaagaactgg acatggttgg taagaaactc   2520
tctaacgaac gcttcgtagc caacgccaaa ccagaagtcg tccaaaaaga atgcgacaaa   2580
caagctgact accaagctaa atatgacgcg accgtcgcac gtattgatga gatgaagaag   2640
ttggtgaaa                                                           2649

<210>   1012
<211>   883
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   valyl-tRNA synthetase (valS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902536 (0.E+01)

<400>   1012
Met Ser Lys Glu Leu Ser Pro Lys Tyr Asn Pro Ala Glu Val Glu Ala 
1               5                   10                  15      

Gly Arg Tyr Gln Lys Trp Leu Asp Ala Asp Val Phe Lys Pro Ser Gly 

            20                  25                  30          

Asp Gln Lys Ala Lys Pro Tyr Ser Ile Val Ile Pro Pro Pro Asn Val 
        35                  40                  45              

Thr Gly Lys Leu His Leu Gly His Ala Trp Asp Thr Thr Leu Gln Asp 
    50                  55                  60                  

Ile Ile Ile Arg Gln Lys Arg Met Gln Gly Phe Asp Thr Leu Trp Leu 
65                  70                  75                  80  

Pro Gly Met Asp His Ala Gly Ile Ala Thr Gln Ala Lys Val Glu Glu 
                85                  90                  95      

Arg Leu Arg Gly Glu Gly Ile Thr Arg Tyr Asp Leu Gly Arg Glu Ser 
            100                 105                 110         

Phe Leu Thr Lys Val Trp Glu Trp Lys Asp Glu Tyr Ala Thr Thr Ile 
        115                 120                 125             

Lys Glu Gln Trp Gly Lys Met Gly Leu Ser Val Asp Tyr Ser Arg Glu 
    130                 135                 140                 

Arg Phe Thr Leu Asp Glu Gly Leu Ser Lys Ala Val Arg Lys Val Phe 
145                 150                 155                 160 

Val Asn Leu Tyr Lys Lys Gly Trp Ile Tyr Arg Gly Glu Phe Ile Ile 
                165                 170                 175     

Asn Trp Asp Pro Ala Ala Arg Thr Ala Leu Ser Asp Ile Glu Val Ile 
            180                 185                 190         

His Lys Asp Val Glu Gly Ala Phe Tyr His Met Asn Tyr Met Leu Glu 
        195                 200                 205             

Asp Gly Ser Arg Ala Leu Glu Val Ala Thr Thr Arg Pro Glu Thr Met 
    210                 215                 220                 

Phe Gly Asp Val Ala Val Ala Val Asn Pro Glu Asp Pro Arg Tyr Lys 
225                 230                 235                 240 

Asp Leu Ile Gly Lys Asn Val Ile Leu Pro Ile Ala Asn Lys Leu Ile 
                245                 250                 255     

Pro Ile Val Gly Asp Glu His Ala Asp Pro Glu Leu Gly Thr Gly Val 
            260                 265                 270         

Val Lys Ile Thr Pro Ala His Asp Pro Asn Asp Phe Leu Val Gly Gln 
        275                 280                 285             

Arg His Asn Leu Pro Gln Val Asn Val Met Asn Asp Asp Gly Thr Met 
    290                 295                 300                 

Asn Glu Leu Ala Phe Glu Phe Ser Gly Met Asp Arg Phe Glu Ala Arg 
305                 310                 315                 320 

Lys Ala Val Val Ala Lys Leu Glu Glu Ile Gly Ala Leu Val Lys Ile 
                325                 330                 335     

Glu Lys Arg Val His Ser Val Gly His Ser Glu Arg Thr Gly Val Val 
            340                 345                 350         

Val Glu Pro Arg Leu Ser Thr Gln Trp Phe Val Lys Met Asp Gln Leu 
        355                 360                 365             

Ala Lys Asn Ala Ile Ala Asn Gln Asp Thr Glu Asp Lys Val Glu Phe 
    370                 375                 380                 

Tyr Pro Pro Arg Phe Asn Asp Thr Phe Leu Gln Trp Met Glu Asn Val 
385                 390                 395                 400 

His Asp Trp Val Ile Ser Arg Gln Leu Trp Trp Gly His Gln Ile Pro 
                405                 410                 415     

Ala Trp Tyr Asn Ala Asp Gly Glu Met Tyr Val Gly Glu Glu Ala Pro 
            420                 425                 430         

Glu Gly Asp Gly Trp Thr Gln Asp Glu Asp Val Leu Asp Thr Trp Phe 
        435                 440                 445             

Ser Ser Ala Leu Trp Pro Phe Ser Thr Met Gly Trp Pro Glu Val Asp 
    450                 455                 460                 

Ser Glu Asp Phe Lys Arg Tyr Phe Pro Thr Ser Thr Leu Val Thr Gly 
465                 470                 475                 480 

Tyr Asp Ile Ile Phe Phe Trp Val Ser Arg Met Ile Phe Gln Ser Leu 
                485                 490                 495     

Glu Phe Thr Gly Arg Gln Pro Phe Gln Asn Val Leu Ile His Gly Leu 
            500                 505                 510         

Ile Arg Asp Glu Gln Gly Arg Lys Met Ser Lys Ser Leu Gly Asn Gly 
        515                 520                 525             

Ile Asp Pro Met Asp Val Ile Glu Lys Tyr Gly Ala Asp Ala Leu Arg 
    530                 535                 540                 

Trp Phe Leu Ser Asn Gly Ser Ala Pro Gly Gln Asp Val Arg Phe Ser 
545                 550                 555                 560 

Tyr Glu Lys Met Asp Ala Ser Trp Asn Phe Ile Asn Lys Ile Trp Asn 
                565                 570                 575     

Ile Ser Arg Tyr Ile Leu Met Asn Asn Glu Gly Leu Thr Leu Asp Val 
            580                 585                 590         

Ala His Asp Asn Val Thr Lys Val Ala Thr Gly Glu Ala Gly Asn Val 
        595                 600                 605             

Thr Asp Arg Trp Ile Leu His Asn Leu Asn Glu Thr Ile Ala Lys Val 
    610                 615                 620                 

Thr Glu Asn Phe Asp Lys Phe Glu Phe Gly Val Ala Gly His Ile Leu 
625                 630                 635                 640 

Tyr Asn Phe Ile Trp Glu Glu Phe Ala Asn Trp Tyr Val Glu Leu Thr 
                645                 650                 655     

Lys Glu Val Leu Tyr Ser Asp Asn Glu Asp Asp Lys Val Ile Thr Arg 
            660                 665                 670         

Ser Val Leu Leu Tyr Thr Leu Asp Lys Ile Leu Arg Leu Leu His Pro 
        675                 680                 685             

Ile Met Pro Phe Val Thr Glu Glu Ile Phe Gly Gln Ile Ser Glu Gly 
    690                 695                 700                 

Ser Ile Val Thr Ala Ala Tyr Pro Thr Val Asn Leu Ala Phe Glu Asp 
705                 710                 715                 720 

Leu Ala Ala His Thr Gly Val Glu Ser Leu Lys Asp Leu Ile Arg Ala 
                725                 730                 735     

Val Arg Asn Ala Arg Ala Glu Val Asn Val Ala Pro Ser Lys Pro Ile 
            740                 745                 750         

Thr Ile Leu Val Lys Thr Ser Asp Ser Asp Leu Glu Ala Phe Phe Asn 
        755                 760                 765             

Ser Asn Val Asn Tyr Ile Lys Arg Phe Thr Asn Pro Glu His Leu Glu 
    770                 775                 780                 

Ile Ala Ser Thr Ile Pro Ala Pro Glu Leu Ala Met Ser Ser Val Ile 
785                 790                 795                 800 

Thr Gly Ala Glu Ile Tyr Leu Pro Leu Ala Asp Leu Leu Asn Val Glu 
                805                 810                 815     

Glu Glu Leu Ala Arg Leu Asp Lys Glu Leu Ala Lys Trp Gln Lys Glu 
            820                 825                 830         

Leu Asp Met Val Gly Lys Lys Leu Ser Asn Glu Arg Phe Val Ala Asn 
        835                 840                 845             

Ala Lys Pro Glu Val Val Gln Lys Glu Cys Asp Lys Gln Ala Asp Tyr 
    850                 855                 860                 

Gln Ala Lys Tyr Asp Ala Thr Val Ala Arg Ile Asp Glu Met Lys Lys 
865                 870                 875                 880 


Leu Val Lys 
            

<210>   1013
<211>   162
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1013
atggggaaaa ttgttgctat tgatttattt aacggtgcag gtggcactac aagtggcctt   60
aaaaaatcag gcatagatgt tcaagttgct gttgaaattg attccgtagc tgttaaaact   120
tataagttaa ataatcctga ggtgtctgta atagatatgg ag                      162

<210>   1014
<211>   54
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type II DNA modification methyltransferase, truncation
<223>   Cellular location: cytoplasm

<400>   1014
Met Gly Lys Ile Val Ala Ile Asp Leu Phe Asn Gly Ala Gly Gly Thr 
1               5                   10                  15      

Thr Ser Gly Leu Lys Lys Ser Gly Ile Asp Val Gln Val Ala Val Glu 
            20                  25                  30          

Ile Asp Ser Val Ala Val Lys Thr Tyr Lys Leu Asn Asn Pro Glu Val 
        35                  40                  45              

Ser Val Ile Asp Met Glu 
    50                  

<210>   1015
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1015
ttggctggag aaccatataa agcttgtaaa attgaagttt tatttactcc atatctatta   60
cagacacctc aggattattt aacttataag ttt                                93

<210>   1016
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1016
Met Ala Gly Glu Pro Tyr Lys Ala Cys Lys Ile Glu Val Leu Phe Thr 
1               5                   10                  15      

Pro Tyr Leu Leu Gln Thr Pro Gln Asp Tyr Leu Thr Tyr Lys Phe 
            20                  25                  30      

<210>   1017
<211>   1602
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1017
gtgtctgaat attggtttag tacaaatgtt gatcaaatag atgaagtgga tgggaaacaa   60
tgtttaatct attcatatta taacattaaa gcttctagaa atgtagaagt tcttaaaggc   120
cgttctggaa caaaaaaagg attagattat tgggaaccat atgctcctca aaaacaatat   180
gagatggaaa gattacccaa aaataaatat attggaagtt cttcgacaga cagatgggat   240
ggcattgaaa aaaatgttgt cttttgtgat tgtaaagaat atgtttctgc ttttgattta   300
tttttctatc actataattt taaaaaaatt tctactcaac gtagtaaaca agattttata   360
agattacgat ctaagccagt tgctgatatt ttaaagaata atacaagtag ctatacgcgt   420
tataaaaagg aaatggttat agataatgtt aaagttgatg ataaagtttg tgaaattatt   480
agtgaaataa tggatgaatc ttatacagac attcaaattt taacacataa gttgtattca   540
aaaggtgatg atataaaagc ttccaaaact atttggatga aaaaatctgg aaaagaatat   600
tccgaggctt ttgcaggaac aggtgaggct agaattattt tgttagtaaa tgatatagta   660
aatgcgcaat caaattcatt aatattaata gatgaacctg aaatctcact tcatccgagt   720
gcaatctata aatttaaaga gtttttactt caagagtgtt taaataaaaa acatcaaatt   780
attatcacta cacattctac acaacttata aaagattttc ctagagaagc cgtgaaactt   840
ttagtgaaaa acggagaaaa ggtagatgtt attgaaaata ttgattatca ggatgcattt   900
tttgaattag gtgatgtgta tcattctagg aagatgattt atgttgaaga tagactagct   960
aaatatattc tagagtttgt tatcactcat tcaggtagtg agaatcttaa acagaattta   1020
gtagtgagat atattcctgg tggagcaaat caaataattt gtaataatat tttaaactca   1080
tcgtatttag attccgataa ccattatttt tggcttgatg gagatcaaaa cactaatgtt   1140
agtgaatcaa ataatttaat gaactatctt gaaaatggtg ttgttatatc agataaaatt   1200
cctgaatcag ataataaaaa tcttgatgat attataaaat tgataacggg atgtccaatt   1260
aaatttaatg tttcaggtaa taaagggcaa aaaaataata ttgaattaat tgcgaaacaa   1320
agaagcttta tagattattg ggctaaatac gtttcttatc ttcctttccc aaccccagag   1380
ttttttttag ctaatttgtg taacagcgta gatagggaag gttatgattt ttctaaagat   1440
ggcaacggaa aagaatattt tagaaaaaaa actcaagtag cgttaggaat agagaatata   1500
acttctgaag atattttcca ggagcaaaga agagctgttt caaaaataca gccagaatca   1560
tcaatgtttc agtgtattaa agaaaaatta gaggcattgt tc                      1602

<210>   1018
<211>   534
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm

<400>   1018
Met Ser Glu Tyr Trp Phe Ser Thr Asn Val Asp Gln Ile Asp Glu Val 
1               5                   10                  15      

Asp Gly Lys Gln Cys Leu Ile Tyr Ser Tyr Tyr Asn Ile Lys Ala Ser 
            20                  25                  30          

Arg Asn Val Glu Val Leu Lys Gly Arg Ser Gly Thr Lys Lys Gly Leu 
        35                  40                  45              

Asp Tyr Trp Glu Pro Tyr Ala Pro Gln Lys Gln Tyr Glu Met Glu Arg 
    50                  55                  60                  

Leu Pro Lys Asn Lys Tyr Ile Gly Ser Ser Ser Thr Asp Arg Trp Asp 
65                  70                  75                  80  

Gly Ile Glu Lys Asn Val Val Phe Cys Asp Cys Lys Glu Tyr Val Ser 
                85                  90                  95      

Ala Phe Asp Leu Phe Phe Tyr His Tyr Asn Phe Lys Lys Ile Ser Thr 
            100                 105                 110         

Gln Arg Ser Lys Gln Asp Phe Ile Arg Leu Arg Ser Lys Pro Val Ala 
        115                 120                 125             

Asp Ile Leu Lys Asn Asn Thr Ser Ser Tyr Thr Arg Tyr Lys Lys Glu 
    130                 135                 140                 

Met Val Ile Asp Asn Val Lys Val Asp Asp Lys Val Cys Glu Ile Ile 
145                 150                 155                 160 

Ser Glu Ile Met Asp Glu Ser Tyr Thr Asp Ile Gln Ile Leu Thr His 
                165                 170                 175     

Lys Leu Tyr Ser Lys Gly Asp Asp Ile Lys Ala Ser Lys Thr Ile Trp 
            180                 185                 190         

Met Lys Lys Ser Gly Lys Glu Tyr Ser Glu Ala Phe Ala Gly Thr Gly 
        195                 200                 205             

Glu Ala Arg Ile Ile Leu Leu Val Asn Asp Ile Val Asn Ala Gln Ser 
    210                 215                 220                 

Asn Ser Leu Ile Leu Ile Asp Glu Pro Glu Ile Ser Leu His Pro Ser 
225                 230                 235                 240 

Ala Ile Tyr Lys Phe Lys Glu Phe Leu Leu Gln Glu Cys Leu Asn Lys 
                245                 250                 255     

Lys His Gln Ile Ile Ile Thr Thr His Ser Thr Gln Leu Ile Lys Asp 
            260                 265                 270         

Phe Pro Arg Glu Ala Val Lys Leu Leu Val Lys Asn Gly Glu Lys Val 
        275                 280                 285             

Asp Val Ile Glu Asn Ile Asp Tyr Gln Asp Ala Phe Phe Glu Leu Gly 
    290                 295                 300                 

Asp Val Tyr His Ser Arg Lys Met Ile Tyr Val Glu Asp Arg Leu Ala 
305                 310                 315                 320 

Lys Tyr Ile Leu Glu Phe Val Ile Thr His Ser Gly Ser Glu Asn Leu 
                325                 330                 335     

Lys Gln Asn Leu Val Val Arg Tyr Ile Pro Gly Gly Ala Asn Gln Ile 
            340                 345                 350         

Ile Cys Asn Asn Ile Leu Asn Ser Ser Tyr Leu Asp Ser Asp Asn His 
        355                 360                 365             

Tyr Phe Trp Leu Asp Gly Asp Gln Asn Thr Asn Val Ser Glu Ser Asn 
    370                 375                 380                 

Asn Leu Met Asn Tyr Leu Glu Asn Gly Val Val Ile Ser Asp Lys Ile 
385                 390                 395                 400 

Pro Glu Ser Asp Asn Lys Asn Leu Asp Asp Ile Ile Lys Leu Ile Thr 
                405                 410                 415     

Gly Cys Pro Ile Lys Phe Asn Val Ser Gly Asn Lys Gly Gln Lys Asn 
            420                 425                 430         

Asn Ile Glu Leu Ile Ala Lys Gln Arg Ser Phe Ile Asp Tyr Trp Ala 
        435                 440                 445             

Lys Tyr Val Ser Tyr Leu Pro Phe Pro Thr Pro Glu Phe Phe Leu Ala 
    450                 455                 460                 

Asn Leu Cys Asn Ser Val Asp Arg Glu Gly Tyr Asp Phe Ser Lys Asp 
465                 470                 475                 480 

Gly Asn Gly Lys Glu Tyr Phe Arg Lys Lys Thr Gln Val Ala Leu Gly 
                485                 490                 495     

Ile Glu Asn Ile Thr Ser Glu Asp Ile Phe Gln Glu Gln Arg Arg Ala 
            500                 505                 510         

Val Ser Lys Ile Gln Pro Glu Ser Ser Met Phe Gln Cys Ile Lys Glu 
        515                 520                 525             

Lys Leu Glu Ala Leu Phe 
    530                 

<210>   1019
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1019
atgcaaccaa cttacaacat tgacaatcca aacttgtctt atgaagcgaa gcgtgattta   60
tggcggatag gttttggtct gcagaaagtt gacaatctag tgccatcagc gtatatggaa   120
tctttggctg agaaacagtc ccggggtgaa ctgacttatg agcaggttta tgaggatgca   180
acggcttatc atcataccat tgatgcgagt acagaggagg cagacttggt ttctctacgt   240
attgtagaac tattgtctcg aagaggcttt agcttcagtc ctgcgatctt acttgctatt   300
cataaggagt tgtttcaaga tatatttgaa ccctcgattc cggtaggtca atttcgtcag   360
actaatatca caaagaatga acctgttttg aatggtgaaa gtgttgtgta ctctgattac   420
tccatgattc aaatgacctt ggattatgat tttaatcagg aaaaacaagt tgcatatgcg   480
acactaaccc aggcggatat ggttaaaaaa atccagcatt ttatttcagg aatctggcag   540
attcatccat ttcgcgaagg aaacactcgg acggtaacgg tatttttgat tcagtatctt   600
cgtgagtttg gttttgatat tgataataca ccatttcagc aacattccaa gtattttcgt   660
gatgccttag tgttagataa tgcaaagatt ttacagcgac gtcctgagtt tttaacagct   720
ttttttgaaa atctcttgct cggtggtcaa aatgatttgt cttcagaaaa aatgtatcta   780
gatttagacc tcgatctttc a                                             801

<210>   1020
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell filamentation protein Fic-related protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902538 (e-151)

<400>   1020
Met Gln Pro Thr Tyr Asn Ile Asp Asn Pro Asn Leu Ser Tyr Glu Ala 
1               5                   10                  15      

Lys Arg Asp Leu Trp Arg Ile Gly Phe Gly Leu Gln Lys Val Asp Asn 
            20                  25                  30          

Leu Val Pro Ser Ala Tyr Met Glu Ser Leu Ala Glu Lys Gln Ser Arg 
        35                  40                  45              

Gly Glu Leu Thr Tyr Glu Gln Val Tyr Glu Asp Ala Thr Ala Tyr His 
    50                  55                  60                  

His Thr Ile Asp Ala Ser Thr Glu Glu Ala Asp Leu Val Ser Leu Arg 
65                  70                  75                  80  

Ile Val Glu Leu Leu Ser Arg Arg Gly Phe Ser Phe Ser Pro Ala Ile 
                85                  90                  95      

Leu Leu Ala Ile His Lys Glu Leu Phe Gln Asp Ile Phe Glu Pro Ser 
            100                 105                 110         

Ile Pro Val Gly Gln Phe Arg Gln Thr Asn Ile Thr Lys Asn Glu Pro 
        115                 120                 125             

Val Leu Asn Gly Glu Ser Val Val Tyr Ser Asp Tyr Ser Met Ile Gln 
    130                 135                 140                 

Met Thr Leu Asp Tyr Asp Phe Asn Gln Glu Lys Gln Val Ala Tyr Ala 
145                 150                 155                 160 

Thr Leu Thr Gln Ala Asp Met Val Lys Lys Ile Gln His Phe Ile Ser 
                165                 170                 175     


Gly Ile Trp Gln Ile His Pro Phe Arg Glu Gly Asn Thr Arg Thr Val 
            180                 185                 190         

Thr Val Phe Leu Ile Gln Tyr Leu Arg Glu Phe Gly Phe Asp Ile Asp 
        195                 200                 205             

Asn Thr Pro Phe Gln Gln His Ser Lys Tyr Phe Arg Asp Ala Leu Val 
    210                 215                 220                 

Leu Asp Asn Ala Lys Ile Leu Gln Arg Arg Pro Glu Phe Leu Thr Ala 
225                 230                 235                 240 

Phe Phe Glu Asn Leu Leu Leu Gly Gly Gln Asn Asp Leu Ser Ser Glu 
                245                 250                 255     

Lys Met Tyr Leu Asp Leu Asp Leu Asp Leu Ser 
            260                 265         

<210>   1021
<211>   1198
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1021
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctat aaaattcctt   60
accttgaaac gactggtatg cctactagaa ttctccttag aaaacgtcgt tttaagtgct   120
atcattgctt gaaaatgatg gtcgctgaaa cttctatcgt caagaaaaat caccaaattc   180
ctcgtattat caaccaaaag attgcgcaaa agttaattga aaagatttct atgaccgata   240
ttgcccatca gctggccatt tcaacttcaa ctgtcattcg aaagctcaat gacttccact   300
ttgagtgtaa ttttagaaat ctgcctaaga ttatgtcttg ggacgttgaa acagtccggg   360
gagtgactgt ttcaatcggg agatggagat gagctttatt gcgcaagatt ttgaaaagct   420
cgatatcatc actgttcttg agggtagaac acaagctgtc atccgagatc actttcttaa   480
atatgataga gccgtccgat gtcgcgtcaa aattattact atggatatgt ttagtcctta   540
ctatgactta gctaaacagc ttcgctttca aatttctagg ctcaggctga aacagtctcc   600
cagactgttt cactcccgaa tgctaaaatc gttcttgatc gctttcatat tgtacaacat   660
cttagccgtg ctatgagtcg tgtgcgtgtc caaatcatga atcagtttca tcgaaaatcc   720
catgaataca aggctatcaa gcgctactgg aaactcattc aacaggatag ccgtaaactc   780
agcgataaac atttttatcg ccctactttt cgtatgcatt taaccaataa agagatttta   840
gacaagcttt tgagctattc acaagacttg aaacatcact atcagctcta tcaactcttg   900
ctgtttcact ttcagaataa ggaaccggag aaatttttcg aacttatcga ggacaatctt   960
aagcaggttc atcctatttt tcagactgtc tttaaaacct tcctcaaaga taaagaaaag   1020
gttatcaacg cccttcaact acactattct aatgccaaac tggaagcgac caataatctc   1080
atcaaactta tcaagcgcaa tgcctttggt tttcgaaact ttgaaaactt caaaaaaacg   1140
gatttttatc gctctgaaca tcaaaaaaga aaggacgaaa tttgtccttt ctcgaact     1198

<210>   1022
<211>   308
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase FRAMESHIFT

<400>   1022
Met Ser Arg Val Arg Val Gln Ile Met Asn Gln Phe His Arg Lys Ser 
1               5                   10                  15      

His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile Gln Gln Asp 
            20                  25                  30          

Ser Arg Lys Leu Ser Asp Lys His Phe Tyr Arg Pro Thr Phe Arg Met 
        35                  40                  45              

His Leu Thr Asn Lys Glu Ile Leu Asp Lys Leu Leu Ser Tyr Ser Gln 
    50                  55                  60                  

Asp Leu Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu Phe His Phe 
65                  70                  75                  80  

Gln Asn Lys Glu Pro Glu Lys Phe Phe Glu Leu Ile Glu Asp Asn Leu 
                85                  90                  95      

Lys Gln Val His Pro Ile Phe Gln Thr Val Phe Lys Thr Phe Leu Lys 
            100                 105                 110         

Asp Lys Glu Lys Val Ile Asn Ala Leu Gln Leu His Tyr Ser Asn Ala 
        115                 120                 125             

Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys Arg Asn Ala 
    130                 135                 140                 

Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Thr Asp Phe Tyr Arg 
145                 150                 155                 160 

Ser Glu His Gln Lys Arg Lys Asp Glu Ile Cys Pro Phe Ser Asn Leu 
                165                 170                 175     

Ala Phe Leu Gln Pro Thr Thr Ile Asp Lys Glu Pro Asn Phe Asp Asp 
            180                 185                 190         

Ile Arg Phe Leu Val Arg Ile Phe Thr Ser Phe Phe Pro Lys Ile Gln 
        195                 200                 205             

Cys Leu Leu Ser Ile Arg Ile Met Lys Asp Arg Gly Leu Asn Leu Asp 
    210                 215                 220                 

Thr Phe Phe Leu Lys Thr Asn His Phe Asp His Arg Ala Arg Asp Phe 
225                 230                 235                 240 

Gln Lys Lys Leu Leu Lys Thr Gln Asp Val Ala Val Lys Ser Leu His 
                245                 250                 255     

Tyr Leu Thr Leu Arg His His Glu Asn Thr Trp Asn Val Ala Glu Met 
            260                 265                 270         

Val Tyr Tyr Gln Tyr Gln Asn Gln Thr His Glu Asp Thr Glu Ser Lys 
        275                 280                 285             

Ile Pro Leu Pro Ser Glu Cys Phe Leu Arg Glu Met Asp Glu Ser Ala 
    290                 295                 300                 

Arg Phe Leu Lys 
305             

<210>   1023
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1023
atgagcttta ttgcgcaaga ttttgaaaag ctcgatatca tcactgttct tgagggtaga   60
acacaagctg tcatccgaga tcactttctt aaatatgata gagccgtccg atgtcgcgtc   120
aaaattatta ctatggatat gtttagtcct tactatgact tagctaaaca gcttcgcttt   180
caaatttcta ggctcaggct gaaacagtct cccagactgt ttcactcccg aatgctaaaa   240
tcgttcttga tcgctttcat attgtacaac atcttagccg tgcta                   285

<210>   1024
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase-related

<400>   1024
Met Ser Phe Ile Ala Gln Asp Phe Glu Lys Leu Asp Ile Ile Thr Val 
1               5                   10                  15      

Leu Glu Gly Arg Thr Gln Ala Val Ile Arg Asp His Phe Leu Lys Tyr 
            20                  25                  30          

Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile Thr Met Asp Met Phe 
        35                  40                  45              

Ser Pro Tyr Tyr Asp Leu Ala Lys Gln Leu Arg Phe Gln Ile Ser Arg 
    50                  55                  60                  

Leu Arg Leu Lys Gln Ser Pro Arg Leu Phe His Ser Arg Met Leu Lys 
65                  70                  75                  80  

Ser Phe Leu Ile Ala Phe Ile Leu Tyr Asn Ile Leu Ala Val Leu 
                85                  90                  95  

<210>   1025
<211>   261
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1025
ttgaaaatga tggtcgctga aacttctatc gtcaagaaaa atcaccaaat tcctcgtatt   60
atcaaccaaa agattgcgca aaagttaatt gaaaagattt ctatgaccga tattgcccat   120
cagctggcca tttcaacttc aactgtcatt cgaaagctca atgacttcca ctttgagtgt   180
aattttagaa atctgcctaa gattatgtct tgggacgttg aaacagtccg gggagtgact   240
gtttcaatcg ggagatggag a                                             261

<210>   1026
<211>   87
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   1026
Met Lys Met Met Val Ala Glu Thr Ser Ile Val Lys Lys Asn His Gln 
1               5                   10                  15      

Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln Lys Leu Ile Glu Lys 
            20                  25                  30          

Ile Ser Met Thr Asp Ile Ala His Gln Leu Ala Ile Ser Thr Ser Thr 
        35                  40                  45              

Val Ile Arg Lys Leu Asn Asp Phe His Phe Glu Cys Asn Phe Arg Asn 
    50                  55                  60                  

Leu Pro Lys Ile Met Ser Trp Asp Val Glu Thr Val Arg Gly Val Thr 
65                  70                  75                  80  

Val Ser Ile Gly Arg Trp Arg 
                85          

<210>   1027
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1027
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctat aaaattcctt   60
accttgaaac gactggtatg cctactagaa ttctccttag aaaacgtcgt tttaagtgct   120
atcattgct                                                           129

<210>   1028
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   1028
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Ile Lys Phe Leu Thr Leu Lys Arg Leu Val Cys Leu Leu Glu Phe Ser 
            20                  25                  30          

Leu Glu Asn Val Val Leu Ser Ala Ile Ile Ala 
        35                  40              

<210>   1029
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1029
atgtacaatt tcagccagtc ttgttataat cagcctatag gaatcaagga ggtgactctt   60
atggctgttt ttgtgtcttt ggatggaatt gtggtagaag tccttgatgt cttttcttct   120
tttaatgggg atagtgagtt tttcttgtgt atagcattt                          159

<210>   1030
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902543 (3.E-24)

<400>   1030
Met Tyr Asn Phe Ser Gln Ser Cys Tyr Asn Gln Pro Ile Gly Ile Lys 
1               5                   10                  15      

Glu Val Thr Leu Met Ala Val Phe Val Ser Leu Asp Gly Ile Val Val 
            20                  25                  30          

Glu Val Leu Asp Val Phe Ser Ser Phe Asn Gly Asp Ser Glu Phe Phe 
        35                  40                  45              

Leu Cys Ile Ala Phe 
    50              

<210>   1031
<211>   828
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1031
atggaacgct ctcagttcga ggagatgttc caacttcaaa gtagtcgctt gacgacgcaa   60
gaaaaattac aattgtttac ctctgtgttt gctggccgtt atgatgttta tgctaagaat   120
tttatcaatg aacaagggaa aattcagtat tttccttcct atgattatgg ttggaagcag   180
ttgccacctg aaaaacggag tttccagaca ttgacgaact ccgttttgaa atctcatttt   240
cgtggggagg cagctatcgg tatctttcct atgcacttag atgatagctg ttattttttg   300
gtactggatt tggatgaagg agattggaaa gaagctggtt taaccattcg aagaatagcc   360
agggaacgcc agatggaagc ccatttagag atttctcgtt cgggtcacgg actccatatt   420
tggttcttct ttgaggaagc gattccgagt cgagaggctc gcttgtttgg aaagaaactg   480
atagaactgg caatgcagga aagtatgcaa ctgtcctttg attcttttga tcgcatgttt   540
ccaaatcagg atgtccttcc taagggggga tttggaaatt tgattgcctt gccttttcaa   600
ggagaagctt accatcaagg gcgaacggtc tttgtggatg aacagtttca gccttatgaa   660
gaccaatgga ggtatctaca agaaattcag aggatttcaa ctgctaaagt ggcactgtta   720
atccaagagg agttaggcaa gcaagaattg gataaggagt tgaaggtcgt tttatccaat   780
atgatccaac ttgaaaaatc gtctgtgaca tccaaggcac ttttttct                828

<210>   1032
<211>   276
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902543 (e-154)

<400>   1032
Met Glu Arg Ser Gln Phe Glu Glu Met Phe Gln Leu Gln Ser Ser Arg 
1               5                   10                  15      

Leu Thr Thr Gln Glu Lys Leu Gln Leu Phe Thr Ser Val Phe Ala Gly 
            20                  25                  30          

Arg Tyr Asp Val Tyr Ala Lys Asn Phe Ile Asn Glu Gln Gly Lys Ile 
        35                  40                  45              

Gln Tyr Phe Pro Ser Tyr Asp Tyr Gly Trp Lys Gln Leu Pro Pro Glu 
    50                  55                  60                  

Lys Arg Ser Phe Gln Thr Leu Thr Asn Ser Val Leu Lys Ser His Phe 
65                  70                  75                  80  

Arg Gly Glu Ala Ala Ile Gly Ile Phe Pro Met His Leu Asp Asp Ser 
                85                  90                  95      

Cys Tyr Phe Leu Val Leu Asp Leu Asp Glu Gly Asp Trp Lys Glu Ala 
            100                 105                 110         

Gly Leu Thr Ile Arg Arg Ile Ala Arg Glu Arg Gln Met Glu Ala His 
        115                 120                 125             

Leu Glu Ile Ser Arg Ser Gly His Gly Leu His Ile Trp Phe Phe Phe 
    130                 135                 140                 

Glu Glu Ala Ile Pro Ser Arg Glu Ala Arg Leu Phe Gly Lys Lys Leu 
145                 150                 155                 160 

Ile Glu Leu Ala Met Gln Glu Ser Met Gln Leu Ser Phe Asp Ser Phe 
                165                 170                 175     

Asp Arg Met Phe Pro Asn Gln Asp Val Leu Pro Lys Gly Gly Phe Gly 
            180                 185                 190         

Asn Leu Ile Ala Leu Pro Phe Gln Gly Glu Ala Tyr His Gln Gly Arg 
        195                 200                 205             

Thr Val Phe Val Asp Glu Gln Phe Gln Pro Tyr Glu Asp Gln Trp Arg 
    210                 215                 220                 

Tyr Leu Gln Glu Ile Gln Arg Ile Ser Thr Ala Lys Val Ala Leu Leu 
225                 230                 235                 240 

Ile Gln Glu Glu Leu Gly Lys Gln Glu Leu Asp Lys Glu Leu Lys Val 
                245                 250                 255     

Val Leu Ser Asn Met Ile Gln Leu Glu Lys Ser Ser Val Thr Ser Lys 
            260                 265                 270         

Ala Leu Phe Ser 
        275     

<210>   1033
<211>   1752
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1033
ttgttagaaa tcgatttgac tttcctgatc gatttgtcct gttattattt cattttacta   60
tatttaaagc aggctatgcg acagccaacc tatcaaattc ctgagagaat gtatttattt   120
ggagaatccg atcattattt atggttgcca agaggtttgc tgtatccatt gcaagataaa   180
tttaagcagg tatctgtgga agataggaga aaggtacaaa ggtctattag cgtggaattt   240
aagggagaac tcacttttga gcaagagtta gccctgtcag atatgacttc taaagaaaat   300
ggtttacttc atgcggagac tggttttggg aagaccgttt taggtgctgc tcttatctct   360
gaacggaaaa caaaaacaat tattctagtc cataataagc aactcttaga ccaatggcta   420
gatcgcttaa actgcttttt gactttcgaa gaggaggagg ctatccgtta tacggcatca   480
ggtcgtgaaa aggtaatcgg ctatgttggg cagtacggtg ggactaagaa atggctgagt   540
aaactggttg atgtcgttat gattcaatct ctatttaagt tggaaaatag tcaaagtctt   600
ttggatgagt atgagatgat gattgtggat gagtgtcatc atgtctctgc cttgatgttt   660
gaaaaagttg ttgctcagtt tagagggaag tatctttacg gtttgacggc tacgcctgag   720
cgtaagaatg gtcatgagcc tattgttttt cagagaattg gtgagatact ccatactgct   780
gataagaggg aaacggattt taaacggcaa ttgcaattaa gattcacttc ttttggtcat   840
ttggaaattg aaaagaccaa agcaagtaat tttatacagc ttagtgattg gattgctact   900
gactcagtga ggaatcagat gattctcaag gatattctag cccaagtggc agaaggacgg   960
aatatcttgg ttttagttaa tcgaattcaa cagatagatg tctttgaaaa attattgaaa   1020
gagaaagagg ttgatgactg ttacattatt agcggaaaaa ccaaagtccg agagagaacg   1080
agtttactgg agacgttaga acagttagat aaagggtttg ttttgttgtc tactggaaaa   1140
tacattggcg aaggttttga cttacctcag ttggacacgc ttatcttggc agcacccttt   1200
tcttggaaaa ataatttgat tcagtatgca ggtcggattc atagaaacta caaggataag   1260

tctttggtgc gtattttcga ttatgtggat attcatgttc cttatttaga aaagatgttt   1320
cagaaacgac aagtagctta tcgaaagatg gattatcgtg tcatcgaggg tgaggagaaa   1380
caattcgttt atgttgatag tagatatgag aaggtgttga gagaggactt agcaggggaa   1440
agacaggaat gtctgcttat tttaccttat gtgcaccaga caaaactgat gaattttcta   1500
aaagaattta ggattagtca aattgagata tgtataccag agacggttgc aaataaagca   1560
tggctagacc agttgaagag ccagaaaatt aaagtgtctt ttactcaatc aaaaatagta   1620
acgcctattc ttttggtgaa taagactatt gtttggtatg gtgcaatgcc attattaggg   1680
aaggtagatg agatgaccat attacgtttg gaatcagcta gtatagtttc tgaactagtg   1740
gcaggtttac ga                                                       1752

<210>   1034
<211>   584
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   helicase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902547 (e-117)

<400>   1034
Met Leu Glu Ile Asp Leu Thr Phe Leu Ile Asp Leu Ser Cys Tyr Tyr 
1               5                   10                  15      

Phe Ile Leu Leu Tyr Leu Lys Gln Ala Met Arg Gln Pro Thr Tyr Gln 
            20                  25                  30          

Ile Pro Glu Arg Met Tyr Leu Phe Gly Glu Ser Asp His Tyr Leu Trp 
        35                  40                  45              

Leu Pro Arg Gly Leu Leu Tyr Pro Leu Gln Asp Lys Phe Lys Gln Val 
    50                  55                  60                  

Ser Val Glu Asp Arg Arg Lys Val Gln Arg Ser Ile Ser Val Glu Phe 
65                  70                  75                  80  

Lys Gly Glu Leu Thr Phe Glu Gln Glu Leu Ala Leu Ser Asp Met Thr 
                85                  90                  95      

Ser Lys Glu Asn Gly Leu Leu His Ala Glu Thr Gly Phe Gly Lys Thr 
            100                 105                 110         

Val Leu Gly Ala Ala Leu Ile Ser Glu Arg Lys Thr Lys Thr Ile Ile 
        115                 120                 125             

Leu Val His Asn Lys Gln Leu Leu Asp Gln Trp Leu Asp Arg Leu Asn 
    130                 135                 140                 

Cys Phe Leu Thr Phe Glu Glu Glu Glu Ala Ile Arg Tyr Thr Ala Ser 
145                 150                 155                 160 

Gly Arg Glu Lys Val Ile Gly Tyr Val Gly Gln Tyr Gly Gly Thr Lys 
                165                 170                 175     

Lys Trp Leu Ser Lys Leu Val Asp Val Val Met Ile Gln Ser Leu Phe 
            180                 185                 190         

Lys Leu Glu Asn Ser Gln Ser Leu Leu Asp Glu Tyr Glu Met Met Ile 
        195                 200                 205             

Val Asp Glu Cys His His Val Ser Ala Leu Met Phe Glu Lys Val Val 
    210                 215                 220                 

Ala Gln Phe Arg Gly Lys Tyr Leu Tyr Gly Leu Thr Ala Thr Pro Glu 
225                 230                 235                 240 

Arg Lys Asn Gly His Glu Pro Ile Val Phe Gln Arg Ile Gly Glu Ile 
                245                 250                 255     

Leu His Thr Ala Asp Lys Arg Glu Thr Asp Phe Lys Arg Gln Leu Gln 
            260                 265                 270         

Leu Arg Phe Thr Ser Phe Gly His Leu Glu Ile Glu Lys Thr Lys Ala 
        275                 280                 285             

Ser Asn Phe Ile Gln Leu Ser Asp Trp Ile Ala Thr Asp Ser Val Arg 
    290                 295                 300                 

Asn Gln Met Ile Leu Lys Asp Ile Leu Ala Gln Val Ala Glu Gly Arg 
305                 310                 315                 320 

Asn Ile Leu Val Leu Val Asn Arg Ile Gln Gln Ile Asp Val Phe Glu 
                325                 330                 335     

Lys Leu Leu Lys Glu Lys Glu Val Asp Asp Cys Tyr Ile Ile Ser Gly 
            340                 345                 350         

Lys Thr Lys Val Arg Glu Arg Thr Ser Leu Leu Glu Thr Leu Glu Gln 
        355                 360                 365             

Leu Asp Lys Gly Phe Val Leu Leu Ser Thr Gly Lys Tyr Ile Gly Glu 
    370                 375                 380                 

Gly Phe Asp Leu Pro Gln Leu Asp Thr Leu Ile Leu Ala Ala Pro Phe 
385                 390                 395                 400 

Ser Trp Lys Asn Asn Leu Ile Gln Tyr Ala Gly Arg Ile His Arg Asn 
                405                 410                 415     

Tyr Lys Asp Lys Ser Leu Val Arg Ile Phe Asp Tyr Val Asp Ile His 
            420                 425                 430         

Val Pro Tyr Leu Glu Lys Met Phe Gln Lys Arg Gln Val Ala Tyr Arg 
        435                 440                 445             

Lys Met Asp Tyr Arg Val Ile Glu Gly Glu Glu Lys Gln Phe Val Tyr 
    450                 455                 460                 

Val Asp Ser Arg Tyr Glu Lys Val Leu Arg Glu Asp Leu Ala Gly Glu 
465                 470                 475                 480 

Arg Gln Glu Cys Leu Leu Ile Leu Pro Tyr Val His Gln Thr Lys Leu 
                485                 490                 495     

Met Asn Phe Leu Lys Glu Phe Arg Ile Ser Gln Ile Glu Ile Cys Ile 
            500                 505                 510         

Pro Glu Thr Val Ala Asn Lys Ala Trp Leu Asp Gln Leu Lys Ser Gln 
        515                 520                 525             

Lys Ile Lys Val Ser Phe Thr Gln Ser Lys Ile Val Thr Pro Ile Leu 
    530                 535                 540                 

Leu Val Asn Lys Thr Ile Val Trp Tyr Gly Ala Met Pro Leu Leu Gly 
545                 550                 555                 560 

Lys Val Asp Glu Met Thr Ile Leu Arg Leu Glu Ser Ala Ser Ile Val 
                565                 570                 575     

Ser Glu Leu Val Ala Gly Leu Arg 
            580                 

<210>   1035
<211>   837
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1035
atgatcataa aacgaatact aaaccacaat gccgtaattg cgcaaagtaa aaaagatatc   60
gatattcttc tttttggaag gggaatagct tttggaagaa aaactggaga taaagtaaat   120
ccaattgata ttgagaaaag tttttttctc aaaaatagag ataatatgac ccgttttaca   180
gagatgttta ttaacgttcc tttggagttg gtgtacatca ccgaaaaaat aattaaccta   240
ggtaaaataa cattgggtaa taattttgat gaaattatct atattaattt aacggatcat   300
atttcttcga gcatagaacg ttataaagaa gggattatta tttcgaatcc cctacgctgg   360
gaaatatcga aatattataa agaagaattt gaacttggga aaagggcttt acaaataata   420
aaaaaagagt taggtattga acttccaatt gacgaagctg cattcatagc gctacatttt   480
gttaatgcta atttagaaaa taattttcaa gagtcgtata aaatcactga aataattatg   540
ggaattgaga aaatcattca agatttctat tgtactgagt ttaaccaaga ttctattgat   600
tattatagat tcataactca tataaaatta tttgcccatc gcttggttga aaatacaact   660
tattgtgacg atgatgatga agacttgtta gcattaatga aaaataaata tcctagagaa   720
tatgaatgtg gtgaacaggt agcaatgttt atacaaacgg agtacaatta tttgctgact   780
tctagtgaat tagtttattt gatggctcat attcgtcgct taacaaaaaa tttagat      837

<210>   1036
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcription antiterminator Lict (licT)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902548 (e-160)

<400>   1036
Met Ile Ile Lys Arg Ile Leu Asn His Asn Ala Val Ile Ala Gln Ser 
1               5                   10                  15      

Lys Lys Asp Ile Asp Ile Leu Leu Phe Gly Arg Gly Ile Ala Phe Gly 
            20                  25                  30          

Arg Lys Thr Gly Asp Lys Val Asn Pro Ile Asp Ile Glu Lys Ser Phe 
        35                  40                  45              

Phe Leu Lys Asn Arg Asp Asn Met Thr Arg Phe Thr Glu Met Phe Ile 
    50                  55                  60                  

Asn Val Pro Leu Glu Leu Val Tyr Ile Thr Glu Lys Ile Ile Asn Leu 
65                  70                  75                  80  

Gly Lys Ile Thr Leu Gly Asn Asn Phe Asp Glu Ile Ile Tyr Ile Asn 
                85                  90                  95      

Leu Thr Asp His Ile Ser Ser Ser Ile Glu Arg Tyr Lys Glu Gly Ile 
            100                 105                 110         

Ile Ile Ser Asn Pro Leu Arg Trp Glu Ile Ser Lys Tyr Tyr Lys Glu 
        115                 120                 125             

Glu Phe Glu Leu Gly Lys Arg Ala Leu Gln Ile Ile Lys Lys Glu Leu 
    130                 135                 140                 

Gly Ile Glu Leu Pro Ile Asp Glu Ala Ala Phe Ile Ala Leu His Phe 
145                 150                 155                 160 

Val Asn Ala Asn Leu Glu Asn Asn Phe Gln Glu Ser Tyr Lys Ile Thr 
                165                 170                 175     

Glu Ile Ile Met Gly Ile Glu Lys Ile Ile Gln Asp Phe Tyr Cys Thr 
            180                 185                 190         

Glu Phe Asn Gln Asp Ser Ile Asp Tyr Tyr Arg Phe Ile Thr His Ile 
        195                 200                 205             

Lys Leu Phe Ala His Arg Leu Val Glu Asn Thr Thr Tyr Cys Asp Asp 
    210                 215                 220                 

Asp Asp Glu Asp Leu Leu Ala Leu Met Lys Asn Lys Tyr Pro Arg Glu 
225                 230                 235                 240 

Tyr Glu Cys Gly Glu Gln Val Ala Met Phe Ile Gln Thr Glu Tyr Asn 
                245                 250                 255     

Tyr Leu Leu Thr Ser Ser Glu Leu Val Tyr Leu Met Ala His Ile Arg 
            260                 265                 270         

Arg Leu Thr Lys Asn Leu Asp 
        275                 

<210>   1037
<211>   1836
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1037
atgagttata aagatacggt acaaaaaatc ctcgatgtaa ttggaggtga aaaaaatgtc   60
aatagagtta cccattgtgt aacacgttta agattagaat taaaagatga aaatttagtc   120
aatgatgatg atgtgaagaa gataccaggt gtaataggta ttatgaaaaa gaatggacaa   180
tatcaaatta tacttggtaa tgatgtagct aattattata aagaattcgt taaacttggc   240
aattttgaat ccgattcagt tgttcaaggg cacaaaggga atattttaga aagaatcatt   300
gagtatatcg ctggttccat gactccaatc attccagcaa tgttaggggg aggtatgttg   360
aaagtcttgg taatcatttt accaatgctt ggtatattgc aatcagattc tcagactatt   420
gcttttttga cattttttgg ggatgctcca tattatttct taccgctgtt attagcttat   480
tctgcatcac aaaaattaaa agtaacatct acattagcta tgtctgtagc aggtgtactt   540
ctccatccaa attttgttca aatggtgcaa tcagggaatc ctcttagttt atttggtgca   600
cctgtgacac cagctagtta tggttcatca gtcgttccaa ttcttattat ggtttggttg   660
atgaaatata ttgaaaaaat aattgctaaa ttaacactag ctattactaa gagttttttg   720
caacctacgc tagtattatt agtatcaagc tgtattgcct tagttgtagt cggacctatt   780
ggagtaattg ttggtgaagg attatcaaat ctagttgggc aaatgtatgg tgtagctgga   840
tggcttacat tagctattct tggtgctatt atgccattta ttgttatgac tggaatgcat   900
tgggcttttg cacctatttt tttggcggca tctattgcta ctccagacgt attaattctt   960
ccagcaatgt tagggtcaaa cttagctcaa ggggctgctt cgatggctgt tgcattaaag   1020
agtaaaaata ataatacaaa acaaattgct tttgcagcag gtttctcagc cttacttgca   1080
gggattaccg aacctgcatt atatggtgtg actttaaaat ataaaaaacc gctttatgca   1140
gctatgattg gtggtggatt agcgggatta tttgcaggtc ttactagtgt taaagcatat   1200
ctatttgctg tcccatcttt gatagcgttg cctcaattta tttattctga tgtgccatca   1260
aatattgtaa atgctttaat tgtggcggtc atttcggttg ttattacctt tgtattagct   1320
tatatatttg gaatcgatga agaagagagt tctagcaatt tagaagttga agctggagtt   1380
tcaaataaaa aaatgatatt ttctcctata tcaggagaaa tcattccgtt aagcgatgtc   1440
caggataaaa cattttcaga taaactaatt ggagacggag tagcgattat cccaagtgaa   1500
ggtaaggttt atgcaccatt tgatgggaaa attacaaata tttttccgac taagcacgca   1560
attggattga agagtgatga gggtgttgag ttactaattc atattggatt agatactgtt   1620
gagctaaaag gtcaaggttt tattagtcat gtagaagaag gagacagagt tttcaaaaat   1680
cagttgattt ttgaaatgga cttgaattta atcaagacta aaggctacga aacagttaca   1740
ccagtaattg taacgaatac caatgatttt ctagatgtat tagtattacc taataatcag   1800
acaatcgagc attctaagga attactggta atatta                             1836

<210>   1038
<211>   612
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, beta-glucosides-specific IIABC components
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902549 (0.E+01)

<400>   1038
Met Ser Tyr Lys Asp Thr Val Gln Lys Ile Leu Asp Val Ile Gly Gly 
1               5                   10                  15      

Glu Lys Asn Val Asn Arg Val Thr His Cys Val Thr Arg Leu Arg Leu 
            20                  25                  30          

Glu Leu Lys Asp Glu Asn Leu Val Asn Asp Asp Asp Val Lys Lys Ile 
        35                  40                  45              

Pro Gly Val Ile Gly Ile Met Lys Lys Asn Gly Gln Tyr Gln Ile Ile 
    50                  55                  60                  

Leu Gly Asn Asp Val Ala Asn Tyr Tyr Lys Glu Phe Val Lys Leu Gly 
65                  70                  75                  80  

Asn Phe Glu Ser Asp Ser Val Val Gln Gly His Lys Gly Asn Ile Leu 
                85                  90                  95      

Glu Arg Ile Ile Glu Tyr Ile Ala Gly Ser Met Thr Pro Ile Ile Pro 
            100                 105                 110         

Ala Met Leu Gly Gly Gly Met Leu Lys Val Leu Val Ile Ile Leu Pro 
        115                 120                 125             

Met Leu Gly Ile Leu Gln Ser Asp Ser Gln Thr Ile Ala Phe Leu Thr 
    130                 135                 140                 

Phe Phe Gly Asp Ala Pro Tyr Tyr Phe Leu Pro Leu Leu Leu Ala Tyr 
145                 150                 155                 160 

Ser Ala Ser Gln Lys Leu Lys Val Thr Ser Thr Leu Ala Met Ser Val 
                165                 170                 175     

Ala Gly Val Leu Leu His Pro Asn Phe Val Gln Met Val Gln Ser Gly 
            180                 185                 190         

Asn Pro Leu Ser Leu Phe Gly Ala Pro Val Thr Pro Ala Ser Tyr Gly 
        195                 200                 205             

Ser Ser Val Val Pro Ile Leu Ile Met Val Trp Leu Met Lys Tyr Ile 
    210                 215                 220                 

Glu Lys Ile Ile Ala Lys Leu Thr Leu Ala Ile Thr Lys Ser Phe Leu 
225                 230                 235                 240 

Gln Pro Thr Leu Val Leu Leu Val Ser Ser Cys Ile Ala Leu Val Val 
                245                 250                 255     

Val Gly Pro Ile Gly Val Ile Val Gly Glu Gly Leu Ser Asn Leu Val 
            260                 265                 270         

Gly Gln Met Tyr Gly Val Ala Gly Trp Leu Thr Leu Ala Ile Leu Gly 
        275                 280                 285             

Ala Ile Met Pro Phe Ile Val Met Thr Gly Met His Trp Ala Phe Ala 
    290                 295                 300                 

Pro Ile Phe Leu Ala Ala Ser Ile Ala Thr Pro Asp Val Leu Ile Leu 
305                 310                 315                 320 

Pro Ala Met Leu Gly Ser Asn Leu Ala Gln Gly Ala Ala Ser Met Ala 
                325                 330                 335     

Val Ala Leu Lys Ser Lys Asn Asn Asn Thr Lys Gln Ile Ala Phe Ala 
            340                 345                 350         

Ala Gly Phe Ser Ala Leu Leu Ala Gly Ile Thr Glu Pro Ala Leu Tyr 
        355                 360                 365             

Gly Val Thr Leu Lys Tyr Lys Lys Pro Leu Tyr Ala Ala Met Ile Gly 
    370                 375                 380                 

Gly Gly Leu Ala Gly Leu Phe Ala Gly Leu Thr Ser Val Lys Ala Tyr 
385                 390                 395                 400 

Leu Phe Ala Val Pro Ser Leu Ile Ala Leu Pro Gln Phe Ile Tyr Ser 
                405                 410                 415     

Asp Val Pro Ser Asn Ile Val Asn Ala Leu Ile Val Ala Val Ile Ser 
            420                 425                 430         

Val Val Ile Thr Phe Val Leu Ala Tyr Ile Phe Gly Ile Asp Glu Glu 
        435                 440                 445             

Glu Ser Ser Ser Asn Leu Glu Val Glu Ala Gly Val Ser Asn Lys Lys 
    450                 455                 460                 

Met Ile Phe Ser Pro Ile Ser Gly Glu Ile Ile Pro Leu Ser Asp Val 
465                 470                 475                 480 

Gln Asp Lys Thr Phe Ser Asp Lys Leu Ile Gly Asp Gly Val Ala Ile 
                485                 490                 495     

Ile Pro Ser Glu Gly Lys Val Tyr Ala Pro Phe Asp Gly Lys Ile Thr 
            500                 505                 510         

Asn Ile Phe Pro Thr Lys His Ala Ile Gly Leu Lys Ser Asp Glu Gly 
        515                 520                 525             

Val Glu Leu Leu Ile His Ile Gly Leu Asp Thr Val Glu Leu Lys Gly 
    530                 535                 540                 

Gln Gly Phe Ile Ser His Val Glu Glu Gly Asp Arg Val Phe Lys Asn 
545                 550                 555                 560 

Gln Leu Ile Phe Glu Met Asp Leu Asn Leu Ile Lys Thr Lys Gly Tyr 
                565                 570                 575     

Glu Thr Val Thr Pro Val Ile Val Thr Asn Thr Asn Asp Phe Leu Asp 
            580                 585                 590         

Val Leu Val Leu Pro Asn Asn Gln Thr Ile Glu His Ser Lys Glu Leu 
        595                 600                 605             

Leu Val Ile Leu 
    610         

<210>   1039
<211>   1413
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1039
atgaccattt ttccagatga ttttctttgg ggtggagctg ttgcagctaa tcaagtagag   60
ggagcatata atgaagatgg taagggctta tcagttcagg atgtgttacc caaaggtgga   120
ttaggagaag caacagaaaa tcctacagaa gataacttaa aattgatagg tattgatttt   180
tatcataaat ataaggaaga tatatccttg ttttctgaaa tgggctttaa tgtttttcgt   240
acttctattg catggagtag aatttttcca aaaggagatg aggaagaacc taacgaagct   300

gggttgaaat attatgatga attgtttgat gaactacatg ctcacgggat agaaccactt   360
gtaactcttt cacactatga gactccatta tatttagcaa gaaaatatca tggatgggtt   420
gataggagaa tgattcattt ttatgaaaaa tttgctcgaa cagttttaga aaggtataaa   480
gataaagtta aatattggct tacatttaac gaagtaaact ctgttttgga attaccattt   540
actagtggag gaatagatat acctaaggag aatctttcga aacaagaatt atatcaagct   600
atacatcatg aattagtcgc ctcaagtttg gttacaaaaa ttgctcgtga gattaattca   660
gagtttaagg tgggatgtat ggtattagct atgccagctt atccaatgac tccaaatcca   720
aaagatgtat gggcgactca tgagtatgag aatctaaatt atctattttc agatgtgcat   780
gttagaggtt attatccgaa ttatgcaaaa agatatttta aggaaaatga cattaacata   840
gagtttgcag ctgaagatgc agagttatta aaaaattata ccgtagattt tttatccttt   900
agctattaca tgagtgtgac tcaatctgct cttccaacac agtataattc aggagaaggg   960
aatattattg gtggtttagt aaatccttat ttagagtctt cagagtgggg atggcaaatt   1020
gatccaattg gactacgtat aattttaaat agatattatg accgttatca aatcccatta   1080
tttatagtag aaaatggatt aggtgctaaa gatcaactaa taaaagatga acttaataac   1140
ttaaccgtcc aagatgatta tagaattcag tatatgaaag aacatttatt gcaagttgct   1200
gaagctctac aggatggtgt tgaaattatg ggctatacgt cttggggatg tattgactgt   1260
gtttctatgt ccactgcaca actttctaaa aggtacggtc tcatttatgt tgatcgaaac   1320
gatgatggaa gtggtacatt aaatcgatat aagaaaatgt cttttacttg gtataaagaa   1380
gtgattgaat caaatggaga atccttattc aaa                                1413

<210>   1040
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   6-phospho-beta-glucosidase (bglA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902550 (0.E+01)

<400>   1040
Met Thr Ile Phe Pro Asp Asp Phe Leu Trp Gly Gly Ala Val Ala Ala 
1               5                   10                  15      

Asn Gln Val Glu Gly Ala Tyr Asn Glu Asp Gly Lys Gly Leu Ser Val 
            20                  25                  30          

Gln Asp Val Leu Pro Lys Gly Gly Leu Gly Glu Ala Thr Glu Asn Pro 
        35                  40                  45              

Thr Glu Asp Asn Leu Lys Leu Ile Gly Ile Asp Phe Tyr His Lys Tyr 
    50                  55                  60                  

Lys Glu Asp Ile Ser Leu Phe Ser Glu Met Gly Phe Asn Val Phe Arg 
65                  70                  75                  80  

Thr Ser Ile Ala Trp Ser Arg Ile Phe Pro Lys Gly Asp Glu Glu Glu 
                85                  90                  95      

Pro Asn Glu Ala Gly Leu Lys Tyr Tyr Asp Glu Leu Phe Asp Glu Leu 
            100                 105                 110         

His Ala His Gly Ile Glu Pro Leu Val Thr Leu Ser His Tyr Glu Thr 
        115                 120                 125             

Pro Leu Tyr Leu Ala Arg Lys Tyr His Gly Trp Val Asp Arg Arg Met 
    130                 135                 140                 

Ile His Phe Tyr Glu Lys Phe Ala Arg Thr Val Leu Glu Arg Tyr Lys 
145                 150                 155                 160 

Asp Lys Val Lys Tyr Trp Leu Thr Phe Asn Glu Val Asn Ser Val Leu 
                165                 170                 175     

Glu Leu Pro Phe Thr Ser Gly Gly Ile Asp Ile Pro Lys Glu Asn Leu 
            180                 185                 190         

Ser Lys Gln Glu Leu Tyr Gln Ala Ile His His Glu Leu Val Ala Ser 
        195                 200                 205             

Ser Leu Val Thr Lys Ile Ala Arg Glu Ile Asn Ser Glu Phe Lys Val 
    210                 215                 220                 

Gly Cys Met Val Leu Ala Met Pro Ala Tyr Pro Met Thr Pro Asn Pro 
225                 230                 235                 240 

Lys Asp Val Trp Ala Thr His Glu Tyr Glu Asn Leu Asn Tyr Leu Phe 
                245                 250                 255     

Ser Asp Val His Val Arg Gly Tyr Tyr Pro Asn Tyr Ala Lys Arg Tyr 
            260                 265                 270         

Phe Lys Glu Asn Asp Ile Asn Ile Glu Phe Ala Ala Glu Asp Ala Glu 
        275                 280                 285             

Leu Leu Lys Asn Tyr Thr Val Asp Phe Leu Ser Phe Ser Tyr Tyr Met 
    290                 295                 300                 

Ser Val Thr Gln Ser Ala Leu Pro Thr Gln Tyr Asn Ser Gly Glu Gly 
305                 310                 315                 320 

Asn Ile Ile Gly Gly Leu Val Asn Pro Tyr Leu Glu Ser Ser Glu Trp 
                325                 330                 335     

Gly Trp Gln Ile Asp Pro Ile Gly Leu Arg Ile Ile Leu Asn Arg Tyr 
            340                 345                 350         

Tyr Asp Arg Tyr Gln Ile Pro Leu Phe Ile Val Glu Asn Gly Leu Gly 
        355                 360                 365             

Ala Lys Asp Gln Leu Ile Lys Asp Glu Leu Asn Asn Leu Thr Val Gln 
    370                 375                 380                 

Asp Asp Tyr Arg Ile Gln Tyr Met Lys Glu His Leu Leu Gln Val Ala 
385                 390                 395                 400 

Glu Ala Leu Gln Asp Gly Val Glu Ile Met Gly Tyr Thr Ser Trp Gly 
                405                 410                 415     

Cys Ile Asp Cys Val Ser Met Ser Thr Ala Gln Leu Ser Lys Arg Tyr 
            420                 425                 430         

Gly Leu Ile Tyr Val Asp Arg Asn Asp Asp Gly Ser Gly Thr Leu Asn 
        435                 440                 445             

Arg Tyr Lys Lys Met Ser Phe Thr Trp Tyr Lys Glu Val Ile Glu Ser 
    450                 455                 460                 

Asn Gly Glu Ser Leu Phe Lys 
465                 470     

<210>   1041
<211>   1044
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1041
atgtcaacta ttgaagaaca attaaaagcg cttcgcgaag aaacgctggc tagcttgaag   60
cagattactg ctggaaatga aaaagagatg caagatttgc gtgtctctgt ccttggtaaa   120
aagggttcgc tcactgaaat cctcaaaggg atgaaagatg tttctgctga gatgcgtcca   180
atcatcggga aacacgtcaa tgaagctcgt gatgtcttga ctgctgcttt tgaagaaaca   240
gctaagctct tggaagaaaa gaaagtcgcg gctcaactgg ctagcgagag tatagatgtg   300
acgcttccag gtcgtccagt tgcgactggt caccgtcacg ttttgacaca aaccagtgaa   360
gaaatcgaag atatcttcat cggtatgggt tatcaagtcg tggatggttt tgaagtggag   420
caagactact ataactttga acgtatgaac cttccaaaag accacccagc tcgtgatatg   480
caggatactt tctatatcac tgaagaaatc ttgctccgta cccacacgtc tccagttcag   540
gcgcgtgcta tggatgccca tgatttttct aaaggtcctt tgaagatgat ctcgccaggg   600
cgtgtcttcc gtcgcgatac ggacgatgcg acccacagtc accaattcca ccaaatcgaa   660
ggcttggtag ttgggaaaaa tatctctatg gctgatcttc aaggaacgct tcagttgatt   720
gtccaaaaaa tgtttggtga agagcgtcaa attcgtttgc gtccatctta cttcccattc   780
acagagccat ctgttgaggt ggatgtttct tgcttcaagt gtggtggaga aggctgtaat   840
gtatgtaaga aaacaggttg gatcgaaatt atgggggccg gtatggttca cccacgtgtc   900
cttgaaatga gtggtatcga tgcgactgta tactctggct ttgcctttgg tcttggacaa   960
gagcgtgtag ctatgctccg ttatggaatc aacgatatcc gtggattcta ccaaggagat   1020
gtccgcttct cagaacagtt taaa                                          1044

<210>   1042
<211>   348
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phenylalanyl-tRNA synthetase, alpha subunit (pheS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902551 (0.E+01)

<400>   1042
Met Ser Thr Ile Glu Glu Gln Leu Lys Ala Leu Arg Glu Glu Thr Leu 
1               5                   10                  15      

Ala Ser Leu Lys Gln Ile Thr Ala Gly Asn Glu Lys Glu Met Gln Asp 
            20                  25                  30          

Leu Arg Val Ser Val Leu Gly Lys Lys Gly Ser Leu Thr Glu Ile Leu 
        35                  40                  45              

Lys Gly Met Lys Asp Val Ser Ala Glu Met Arg Pro Ile Ile Gly Lys 
    50                  55                  60                  

His Val Asn Glu Ala Arg Asp Val Leu Thr Ala Ala Phe Glu Glu Thr 
65                  70                  75                  80  

Ala Lys Leu Leu Glu Glu Lys Lys Val Ala Ala Gln Leu Ala Ser Glu 
                85                  90                  95      

Ser Ile Asp Val Thr Leu Pro Gly Arg Pro Val Ala Thr Gly His Arg 
            100                 105                 110         

His Val Leu Thr Gln Thr Ser Glu Glu Ile Glu Asp Ile Phe Ile Gly 
        115                 120                 125             

Met Gly Tyr Gln Val Val Asp Gly Phe Glu Val Glu Gln Asp Tyr Tyr 

    130                 135                 140                 

Asn Phe Glu Arg Met Asn Leu Pro Lys Asp His Pro Ala Arg Asp Met 
145                 150                 155                 160 

Gln Asp Thr Phe Tyr Ile Thr Glu Glu Ile Leu Leu Arg Thr His Thr 
                165                 170                 175     

Ser Pro Val Gln Ala Arg Ala Met Asp Ala His Asp Phe Ser Lys Gly 
            180                 185                 190         

Pro Leu Lys Met Ile Ser Pro Gly Arg Val Phe Arg Arg Asp Thr Asp 
        195                 200                 205             

Asp Ala Thr His Ser His Gln Phe His Gln Ile Glu Gly Leu Val Val 
    210                 215                 220                 

Gly Lys Asn Ile Ser Met Ala Asp Leu Gln Gly Thr Leu Gln Leu Ile 
225                 230                 235                 240 

Val Gln Lys Met Phe Gly Glu Glu Arg Gln Ile Arg Leu Arg Pro Ser 
                245                 250                 255     

Tyr Phe Pro Phe Thr Glu Pro Ser Val Glu Val Asp Val Ser Cys Phe 
            260                 265                 270         

Lys Cys Gly Gly Glu Gly Cys Asn Val Cys Lys Lys Thr Gly Trp Ile 
        275                 280                 285             

Glu Ile Met Gly Ala Gly Met Val His Pro Arg Val Leu Glu Met Ser 
    290                 295                 300                 

Gly Ile Asp Ala Thr Val Tyr Ser Gly Phe Ala Phe Gly Leu Gly Gln 
305                 310                 315                 320 

Glu Arg Val Ala Met Leu Arg Tyr Gly Ile Asn Asp Ile Arg Gly Phe 
                325                 330                 335     

Tyr Gln Gly Asp Val Arg Phe Ser Glu Gln Phe Lys 
            340                 345             

<210>   1043

<211>   507
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1043
atgattagaa aagtagaaat ggcagatgtt gaggtgttgg ctaaaattgc caaacaaacc   60
tttcgtgaaa cctttgcgta tgataatacg gaagagcagt tacaggaata ctttgaagag   120
gcttatagtc tgaaaacttt gtcaactgag ttgggaaatc ctgactctga aacctatttc   180
attatgcatg aggaggagat agctggtttt ctcaaagtca actggggaag tgctcaaact   240
gagagagaat tagaggacgc ttttgaaatt caacgtctct atgtgctaca aaaattccaa   300
ggatttggac taggtaagca actgtttgaa ttcgcacttg aacttgctac aaaaaatagt   360
ttttcttggg cttggctagg tgtttgggag cataatacaa aagctcaagc gttttataac   420
cgatatggtt ttgaaaaatt tagccaacat cattttatgg ttggtcaaaa agtagatacg   480
gattggttac tgagaaagaa attaagg                                       507

<210>   1044
<211>   169
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902552 (8.E-97)

<400>   1044
Met Ile Arg Lys Val Glu Met Ala Asp Val Glu Val Leu Ala Lys Ile 
1               5                   10                  15      

Ala Lys Gln Thr Phe Arg Glu Thr Phe Ala Tyr Asp Asn Thr Glu Glu 
            20                  25                  30          

Gln Leu Gln Glu Tyr Phe Glu Glu Ala Tyr Ser Leu Lys Thr Leu Ser 
        35                  40                  45              

Thr Glu Leu Gly Asn Pro Asp Ser Glu Thr Tyr Phe Ile Met His Glu 
    50                  55                  60                  

Glu Glu Ile Ala Gly Phe Leu Lys Val Asn Trp Gly Ser Ala Gln Thr 
65                  70                  75                  80  

Glu Arg Glu Leu Glu Asp Ala Phe Glu Ile Gln Arg Leu Tyr Val Leu 
                85                  90                  95      

Gln Lys Phe Gln Gly Phe Gly Leu Gly Lys Gln Leu Phe Glu Phe Ala 
            100                 105                 110         

Leu Glu Leu Ala Thr Lys Asn Ser Phe Ser Trp Ala Trp Leu Gly Val 
        115                 120                 125             

Trp Glu His Asn Thr Lys Ala Gln Ala Phe Tyr Asn Arg Tyr Gly Phe 
    130                 135                 140                 

Glu Lys Phe Ser Gln His His Phe Met Val Gly Gln Lys Val Asp Thr 
145                 150                 155                 160 

Asp Trp Leu Leu Arg Lys Lys Leu Arg 
                165                 

<210>   1045
<211>   2403
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1045
atgcttgtat cttataaatg gttaaaagaa ttggtggaca ttgatgtgcc atcacaagag   60
ttggctgaaa aaatgtcaac tacagggatc gaggtagagg gtgtcgaatc accagctgct   120
ggtctctcaa aaattgtcgt cggtgaggtc ttgtcttgcg aagatgtgcc agagactcac   180
ctccatgttt gtcagattaa cgttggcgaa gaagaagagc gtcagatcgt ttgtggtgcc   240
ccaaatgtgc gtgctgggat caaggtcatg gtggctcttc caggagctcg tatcgctgat   300
aactacaaaa tcaaaaaagg aaaaatccgt ggtttggagt cacttggaat gatctgttca   360
cttggtgaat tgggaatttc tgactcagtt gtgcctaagg aattcgcaga tggcatccaa   420
atcttgcctg aagatgccgt gccaggtgag gaagtctttt cttacctaga cttggatgat   480
gaaatcatcg aactttccat cacaccaaac cgtgcagatg ccctttctat gtgtggagtg   540
gctcacgaag tggcagccat ctatgacaag gcagtcaact ttaaaaaatt tactctaaca   600
gaaactaatg aagctgcggc agatgccctt tctgtcagca ttgagacaga caaggcgcct   660
tactatgcag ctcgtatctt ggacaatgtg actatcgcac caagtccaca atggttgcaa   720
aaccttctca tgaacgaagg catccgtccc atcaataacg ttgtagacgt gacaaactac   780
atcctgctct actttggtca acctatgcat gcttttgact tggacacatt tgaagggact   840
gacatccgtg tgcgtgaagc gcgtgatggt gaaaaattag tgaccctgga cggtgaagaa   900
cgagacttgg ctgagacaga cctcgtgatt acagttgctg acaaaccagt agcccttgcc   960
ggtgttatgg gtggtcaggc tacagaaatt tctgaaaaat ctagtcgtgt tatccttgaa   1020
gctgctgttt ttaatggcaa atctatccgt aagacaagtg gtcgcctgaa ccttcgttct   1080
gagtcatctt ctcgctttga aaaaggaatt aatgtggcaa cagttaatga agcccttgat   1140
gcggcagcta gcatgattgc agagcttgca ggcgcgacgg tgcgtaaggg tatcgtttca   1200
gcgggtgagc ttgatacctc tgatgtggaa gtttcttcaa cccttgctga tgttaaccgt   1260
gtcctcggaa ctgagctgtc ttatgctgat gtagaagacg tcttccgtcg tcttggcttt   1320
ggtctttctg gaaatgcaga cagctttaca gtcagcgtac cacgtcgtcg ttgggatatc   1380
acaatcgaag ctgatctctt tgaagaaatc gctcgtatct atggatatga ccgcttgcca   1440
accagccttc caaaagacga tggtacagct ggtgaattga ctgtgataca aaaactccgc   1500
cgtcaagttc gtaccattgc tgaaggagca ggtttgacag aaatcatcac ctatgctctg   1560
acaactcctg aaaaagcagt tgagttcaca gctcaaccaa gtaaccttac tgaactcatg   1620
tggccaatga ctgtggatcg ttcagtcctc cgtcaaaata tgatttcagg gatccttgat   1680
accgttgcct acaacgtggc tcgtaagaat aaaaacttgg ccctttatga gattggaaaa   1740
gtctttgaac aaacaggtaa tccaaaagaa gaacttccaa atgagatcaa cagctttgcc   1800
tttgccttga caggcttggt tgctgaaaaa gatttccaaa cagcagcagt tccagttgat   1860
ttcttctatg ctaagggaat ccttgaagcc ctatttactc gtttgggact ccaagtaacc   1920
tatacagcaa catctgaaat cgttagcctt catccaggtc gtacagccgt gatttcactc   1980
ggtgaccaag ttcttggttt ccttggccaa gtgcatccag tcactgccaa ggcttacgat   2040
attccagaaa cgtatgtagc tgagcttaac ctttcagcca tcgaaggggc gctccaacct   2100
gctgttccat ttgtggaaat caccaaattc ccagcagtca gccgtgacgt tgcccttctc   2160
ctcaaggcag aagtgactca ccaagaagtt gtagatgcta tccaagctgc cggcgtgaaa   2220
cgtttgacag atatcaaact ctttgacgtc ttctcaggtg aaaaactggg acttggtatg   2280
aagtcaatgg cttatagctt gaccttccaa aatccagaag acagcttaac ggacgaagaa   2340
gtcgcacgct atatggaaaa aatccaagcg tctctcgaag aaaaagtcaa tgcagaagtg   2400
cgt                                                                 2403

<210>   1046
<211>   801
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phenylalanyl-tRNA synthetase, beta subunit (pheT)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902553 (0.E+01)

<400>   1046
Met Leu Val Ser Tyr Lys Trp Leu Lys Glu Leu Val Asp Ile Asp Val 
1               5                   10                  15      

Pro Ser Gln Glu Leu Ala Glu Lys Met Ser Thr Thr Gly Ile Glu Val 
            20                  25                  30          

Glu Gly Val Glu Ser Pro Ala Ala Gly Leu Ser Lys Ile Val Val Gly 
        35                  40                  45              

Glu Val Leu Ser Cys Glu Asp Val Pro Glu Thr His Leu His Val Cys 
    50                  55                  60                  

Gln Ile Asn Val Gly Glu Glu Glu Glu Arg Gln Ile Val Cys Gly Ala 
65                  70                  75                  80  

Pro Asn Val Arg Ala Gly Ile Lys Val Met Val Ala Leu Pro Gly Ala 
                85                  90                  95      

Arg Ile Ala Asp Asn Tyr Lys Ile Lys Lys Gly Lys Ile Arg Gly Leu 
            100                 105                 110         

Glu Ser Leu Gly Met Ile Cys Ser Leu Gly Glu Leu Gly Ile Ser Asp 
        115                 120                 125             

Ser Val Val Pro Lys Glu Phe Ala Asp Gly Ile Gln Ile Leu Pro Glu 
    130                 135                 140                 

Asp Ala Val Pro Gly Glu Glu Val Phe Ser Tyr Leu Asp Leu Asp Asp 
145                 150                 155                 160 

Glu Ile Ile Glu Leu Ser Ile Thr Pro Asn Arg Ala Asp Ala Leu Ser 
                165                 170                 175     

Met Cys Gly Val Ala His Glu Val Ala Ala Ile Tyr Asp Lys Ala Val 
            180                 185                 190         

Asn Phe Lys Lys Phe Thr Leu Thr Glu Thr Asn Glu Ala Ala Ala Asp 
        195                 200                 205             

Ala Leu Ser Val Ser Ile Glu Thr Asp Lys Ala Pro Tyr Tyr Ala Ala 
    210                 215                 220                 

Arg Ile Leu Asp Asn Val Thr Ile Ala Pro Ser Pro Gln Trp Leu Gln 
225                 230                 235                 240 

Asn Leu Leu Met Asn Glu Gly Ile Arg Pro Ile Asn Asn Val Val Asp 
                245                 250                 255     

Val Thr Asn Tyr Ile Leu Leu Tyr Phe Gly Gln Pro Met His Ala Phe 
            260                 265                 270         

Asp Leu Asp Thr Phe Glu Gly Thr Asp Ile Arg Val Arg Glu Ala Arg 
        275                 280                 285             

Asp Gly Glu Lys Leu Val Thr Leu Asp Gly Glu Glu Arg Asp Leu Ala 
    290                 295                 300                 

Glu Thr Asp Leu Val Ile Thr Val Ala Asp Lys Pro Val Ala Leu Ala 
305                 310                 315                 320 

Gly Val Met Gly Gly Gln Ala Thr Glu Ile Ser Glu Lys Ser Ser Arg 
                325                 330                 335     

Val Ile Leu Glu Ala Ala Val Phe Asn Gly Lys Ser Ile Arg Lys Thr 
            340                 345                 350         

Ser Gly Arg Leu Asn Leu Arg Ser Glu Ser Ser Ser Arg Phe Glu Lys 
        355                 360                 365             

Gly Ile Asn Val Ala Thr Val Asn Glu Ala Leu Asp Ala Ala Ala Ser 
    370                 375                 380                 

Met Ile Ala Glu Leu Ala Gly Ala Thr Val Arg Lys Gly Ile Val Ser 
385                 390                 395                 400 

Ala Gly Glu Leu Asp Thr Ser Asp Val Glu Val Ser Ser Thr Leu Ala 
                405                 410                 415     

Asp Val Asn Arg Val Leu Gly Thr Glu Leu Ser Tyr Ala Asp Val Glu 
            420                 425                 430         

Asp Val Phe Arg Arg Leu Gly Phe Gly Leu Ser Gly Asn Ala Asp Ser 
        435                 440                 445             

Phe Thr Val Ser Val Pro Arg Arg Arg Trp Asp Ile Thr Ile Glu Ala 
    450                 455                 460                 

Asp Leu Phe Glu Glu Ile Ala Arg Ile Tyr Gly Tyr Asp Arg Leu Pro 
465                 470                 475                 480 

Thr Ser Leu Pro Lys Asp Asp Gly Thr Ala Gly Glu Leu Thr Val Ile 
                485                 490                 495     

Gln Lys Leu Arg Arg Gln Val Arg Thr Ile Ala Glu Gly Ala Gly Leu 
            500                 505                 510         

Thr Glu Ile Ile Thr Tyr Ala Leu Thr Thr Pro Glu Lys Ala Val Glu 
        515                 520                 525             

Phe Thr Ala Gln Pro Ser Asn Leu Thr Glu Leu Met Trp Pro Met Thr 
    530                 535                 540                 

Val Asp Arg Ser Val Leu Arg Gln Asn Met Ile Ser Gly Ile Leu Asp 
545                 550                 555                 560 

Thr Val Ala Tyr Asn Val Ala Arg Lys Asn Lys Asn Leu Ala Leu Tyr 
                565                 570                 575     

Glu Ile Gly Lys Val Phe Glu Gln Thr Gly Asn Pro Lys Glu Glu Leu 
            580                 585                 590         

Pro Asn Glu Ile Asn Ser Phe Ala Phe Ala Leu Thr Gly Leu Val Ala 
        595                 600                 605             

Glu Lys Asp Phe Gln Thr Ala Ala Val Pro Val Asp Phe Phe Tyr Ala 
    610                 615                 620                 

Lys Gly Ile Leu Glu Ala Leu Phe Thr Arg Leu Gly Leu Gln Val Thr 
625                 630                 635                 640 

Tyr Thr Ala Thr Ser Glu Ile Val Ser Leu His Pro Gly Arg Thr Ala 
                645                 650                 655     

Val Ile Ser Leu Gly Asp Gln Val Leu Gly Phe Leu Gly Gln Val His 
            660                 665                 670         

Pro Val Thr Ala Lys Ala Tyr Asp Ile Pro Glu Thr Tyr Val Ala Glu 
        675                 680                 685             

Leu Asn Leu Ser Ala Ile Glu Gly Ala Leu Gln Pro Ala Val Pro Phe 
    690                 695                 700                 

Val Glu Ile Thr Lys Phe Pro Ala Val Ser Arg Asp Val Ala Leu Leu 
705                 710                 715                 720 

Leu Lys Ala Glu Val Thr His Gln Glu Val Val Asp Ala Ile Gln Ala 
                725                 730                 735     

Ala Gly Val Lys Arg Leu Thr Asp Ile Lys Leu Phe Asp Val Phe Ser 
            740                 745                 750         

Gly Glu Lys Leu Gly Leu Gly Met Lys Ser Met Ala Tyr Ser Leu Thr 
        755                 760                 765             

Phe Gln Asn Pro Glu Asp Ser Leu Thr Asp Glu Glu Val Ala Arg Tyr 
    770                 775                 780                 

Met Glu Lys Ile Gln Ala Ser Leu Glu Glu Lys Val Asn Ala Glu Val 
785                 790                 795                 800 

Arg 
    

<210>   1047
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1047
ttggactttg gctattccaa gttcctcttt caaaaggtgg cagtgcattt aatgcgtccc   60
tatgagagct tatttttgca agtgctccat gacgca                             96

<210>   1048
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1048
Met Asp Phe Gly Tyr Ser Lys Phe Leu Phe Gln Lys Val Ala Val His 
1               5                   10                  15      

Leu Met Arg Pro Tyr Glu Ser Leu Phe Leu Gln Val Leu His Asp Ala 
            20                  25                  30          


<210>   1049
<211>   999
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1049
atgattaaaa catttctctc tgccctttcg gtcattctct tttctatccc tatcataact   60
tattcttttt tcccatcttc taatcttaac atttggctat ctacccaacc tatcttggca   120
cagatttatg ccttcccctt agctactgca actatggctg ctattttaag tttcttattt   180
tttttcctat ctttttacaa gaaaaataaa caaatacggt tttactctgg cattttgctc   240
ttactatcgc tcatattact attattcgga acagataaaa ccctttcttc tgcatcaaat   300
aagactaaaa ccttaaaatt agtaacttgg aacgtcgcta atcaaataga agcacaacat   360
attgagcgaa tttttagcca ttttgacgcc gatatggcta tattccctga actagctacc   420
aatatcagag gtgagcaaga aaaccagaga atcaaactat tgtttcatca agttggactt   480
tctatggcca actatgatat tttcacttct ccacctacca atagtggaat agctcctgtg   540
actgtgattg tcaagaaaag ttatggtttc tatacagaag ctaaaacttt tcatacaaca   600
cggttcggga caattgtatt acattcgaga aaacaaaata taccagatat cattgccttg   660
catactgcgc ctcctctgcc aggtttaatg gaaatctgga agcaagactt aaacatcatt   720
cataatcaat tggcttcaaa atatccaaag gctattattg caggtgattt taatgcaact   780
atgcgtcatg gagcacttgc aaaaataagc tctcataggg acgcattaaa tgcactgcca   840
ccttttgaaa gaggaacttg gaatagccaa agtccaaaac tttttaatgc aacaatagat   900
catattttat tgcctaaaaa ccactactat gttaaagatt tagacattgt aagttttcaa   960
aactctgatc atagatgtat ttttacagaa atcacattt                          999

<210>   1050
<211>   333
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902554 (0.E+01)

<400>   1050
Met Ile Lys Thr Phe Leu Ser Ala Leu Ser Val Ile Leu Phe Ser Ile 
1               5                   10                  15      

Pro Ile Ile Thr Tyr Ser Phe Phe Pro Ser Ser Asn Leu Asn Ile Trp 
            20                  25                  30          

Leu Ser Thr Gln Pro Ile Leu Ala Gln Ile Tyr Ala Phe Pro Leu Ala 
        35                  40                  45              

Thr Ala Thr Met Ala Ala Ile Leu Ser Phe Leu Phe Phe Phe Leu Ser 
    50                  55                  60                  

Phe Tyr Lys Lys Asn Lys Gln Ile Arg Phe Tyr Ser Gly Ile Leu Leu 
65                  70                  75                  80  

Leu Leu Ser Leu Ile Leu Leu Leu Phe Gly Thr Asp Lys Thr Leu Ser 
                85                  90                  95      

Ser Ala Ser Asn Lys Thr Lys Thr Leu Lys Leu Val Thr Trp Asn Val 
            100                 105                 110         

Ala Asn Gln Ile Glu Ala Gln His Ile Glu Arg Ile Phe Ser His Phe 
        115                 120                 125             

Asp Ala Asp Met Ala Ile Phe Pro Glu Leu Ala Thr Asn Ile Arg Gly 
    130                 135                 140                 

Glu Gln Glu Asn Gln Arg Ile Lys Leu Leu Phe His Gln Val Gly Leu 
145                 150                 155                 160 

Ser Met Ala Asn Tyr Asp Ile Phe Thr Ser Pro Pro Thr Asn Ser Gly 
                165                 170                 175     

Ile Ala Pro Val Thr Val Ile Val Lys Lys Ser Tyr Gly Phe Tyr Thr 
            180                 185                 190         

Glu Ala Lys Thr Phe His Thr Thr Arg Phe Gly Thr Ile Val Leu His 
        195                 200                 205             

Ser Arg Lys Gln Asn Ile Pro Asp Ile Ile Ala Leu His Thr Ala Pro 
    210                 215                 220                 

Pro Leu Pro Gly Leu Met Glu Ile Trp Lys Gln Asp Leu Asn Ile Ile 
225                 230                 235                 240 

His Asn Gln Leu Ala Ser Lys Tyr Pro Lys Ala Ile Ile Ala Gly Asp 
                245                 250                 255     

Phe Asn Ala Thr Met Arg His Gly Ala Leu Ala Lys Ile Ser Ser His 
            260                 265                 270         

Arg Asp Ala Leu Asn Ala Leu Pro Pro Phe Glu Arg Gly Thr Trp Asn 
        275                 280                 285             

Ser Gln Ser Pro Lys Leu Phe Asn Ala Thr Ile Asp His Ile Leu Leu 
    290                 295                 300                 

Pro Lys Asn His Tyr Tyr Val Lys Asp Leu Asp Ile Val Ser Phe Gln 
305                 310                 315                 320 

Asn Ser Asp His Arg Cys Ile Phe Thr Glu Ile Thr Phe 
                325                 330             

<210>   1051
<211>   416
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1051
atgcaagaca attatactac aaaaggcaaa catttgacaa tcgatagccg tcgcttaatc   60
gaacgatgga aaaaagaagg aaaatcaaat agagaaattg cctctctact tggaaaagct   120
cctcaaacta tccacactga aatcaagcgt gggacagtcc gacaatgtct tggaaaaggg   180
cgcttcaaag agatttattc tgccgactac gctcaacagt cttaagaaac taaaggaaaa   240
gattctccac tatacataac caaaaacata accaaaaatt ttcgcctgaa atgatggtga   300
tggctaaagg ggttaacgtg ggaatttcaa ccatttacta ttggattcat cgtggaaaat   360
tggggttaag caagcaggaa ctgctttatc ctagaaaagg aaaatcgctt aagaaa       416

<210>   1052
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1239, transposase, putative, truncation POINT MUTATION FRAMESHIFT


<400>   1052
Met Gln Asp Asn Tyr Thr Thr Lys Gly Lys His Leu Thr Ile Asp Ser 
1               5                   10                  15      

Arg Arg Leu Ile Glu Arg Trp Lys Lys Glu Gly Lys Ser Asn Arg Glu 
            20                  25                  30          

Ile Ala Ser Leu Leu Gly Lys Ala Pro Gln Thr Ile His Thr Glu Ile 
        35                  40                  45              

Lys Arg Gly Thr Val Arg Gln Cys Leu Gly Lys Gly Arg Phe Lys Glu 
    50                  55                  60                  

Ile Tyr Ser Ala Asp Tyr Ala Gln Gln Ser 
65                  70                  

<210>   1053
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1053
atgatggtga tggctaaagg ggttaacgtg ggaatttcaa ccatttacta ttggattcat   60
cgtggaaaat tggggttaag caagcaggaa ctgctttatc ctagaaaagg aaaatcgctt   120
aagaaa                                                              126

<210>   1054
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   insertion sequence IS1239 putative transposase-related

<400>   1054
Met Met Val Met Ala Lys Gly Val Asn Val Gly Ile Ser Thr Ile Tyr 
1               5                   10                  15      

Tyr Trp Ile His Arg Gly Lys Leu Gly Leu Ser Lys Gln Glu Leu Leu 
            20                  25                  30          

Tyr Pro Arg Lys Gly Lys Ser Leu Lys Lys 
        35                  40          

<210>   1055
<211>   210
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   1055
atgcgagtgg ctatcatgag cgagttgatt gaggctaggt atgaacaagg aatcagtcag   60
aaaaagctgg aagaagtcag tggaataagc cagcctgtca tagctaggat ggagacagga   120
aagactagtc ctcagttgga tacagtctta aaagtcctag ccagtttagg aaagacacta   180
gcaatcgtcc cacttgaaca gggaaaaagt                                    210

<210>   1056
<211>   70
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902557 (2.E-32)

<400>   1056
Met Arg Val Ala Ile Met Ser Glu Leu Ile Glu Ala Arg Tyr Glu Gln 
1               5                   10                  15      

Gly Ile Ser Gln Lys Lys Leu Glu Glu Val Ser Gly Ile Ser Gln Pro 
            20                  25                  30          

Val Ile Ala Arg Met Glu Thr Gly Lys Thr Ser Pro Gln Leu Asp Thr 
        35                  40                  45              

Val Leu Lys Val Leu Ala Ser Leu Gly Lys Thr Leu Ala Ile Val Pro 
    50                  55                  60                  

Leu Glu Gln Gly Lys Ser 
65                  70  

<210>   1057
<211>   2247
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1057
atgtcaacta caatcatcgg tttccctcgt ttgggcgaat tccgtgaatt aaaatttaca   60
actgaaaaat actttagaaa agaaatctca gaagaagaac ttttagcagc agcaaaagac   120
ttgcgtgcta aacactggaa cattgtcaaa gaaaaaggca tcactgaaat tccatcaaat   180
gacttttctc actatgataa cttcctagat gcggctttcc ttttcaacgt ggtgcctgca   240
tccgttcaaa acttggactt gtctgacctt gagcgctact tcgctttggg acgtggttac   300
cagggagaaa aaggggacgt tcgcgccctt ccaatgaaga aatggttcaa cactaactac   360
cactacatcg ttcctaaatt tgaaaaagac actcaagtaa aattggctgg tcacaagatt   420
ttcgatgagt tccaagaagc caaagaactt ggattgaaca ctcgtcctgt tcttgtaggt   480
cccttcactt tccttcaatt gtcagacttt gaagaaggcg tgaaagcaga cgacttcgta   540
gatagcttag tggctgctta ccaagaagtt tttgctaaat tggctgaact tggtgcgact   600
cgcatccaat tggatgaagc ggctcttgta aaagacttga cagctgaaga aaaagctctc   660
ttcttgaacc tttacaacaa actcttggct gacaaaaaag gtcttgaagt cttgcttcaa   720
acttatttcg gtgatgttcg tgacgtatac gctgaccttg taaacttacc agtagatgct   780
atcggtcttg actttgttga aggtaagaaa actcttgaac tcgttaaagg tggcttccca   840
gctgacaaga ctctctatgt aggtattgtc aatggtaaaa acatctggcg caacaactac   900
gaaaagagct tggctgttct tgagcaaatt ccagctgaaa acatcgtttt gacaagctct   960
tgctcacttc ttcatgtgcc atttacaact gctaatgaag aatttgaacc agcactcttg   1020
aaccactttg cctttgcagt tgaaaaattg gatgaaatcc gtgacttgga tgctatccga   1080
aatggtcaag gttcagaagc tcttgcagcc aacaaagaac tctttgcgac tgagcgtgtt   1140
ggtgaaaatg ctgaacttcg tgcgcgtatc gctggcttga cagacgcaga ctacactcgt   1200
ttgccagcct ttgcagaacg tgaagctatc caagaagaag ctttcaaact tccagctctt   1260
ccaacaacaa cgattggttc attccctcaa acaaaagaag ttcgtgccaa acgtttggct   1320
taccgtaaag gtgaattgtc tcaaaaagag tacgacgctt tccttgctga aacgattgac   1380
gaatggatca agtggcaaga agatattgac tttgatgtcc ttgttcacgg tgaatttgag   1440
cgtaatgaca tggttgagta cttcggtcaa aacttgtcag gatacctctt ctctaaaaat   1500
ggatgggtac aatcatacgg tatgcgtggg gtaaaaccac caatcatctg gggtgatgtc   1560
actcgtctta accctatcac tgttaaatgg tctagctatg cacaaagtcg tacaaacaaa   1620
cctgttaaag gtatgttgac tggacctgtt accatcctta actggtcatt cccacgtgaa   1680
gacatctcta tcaaggattc aactctccaa atcgcccttg ctatcaagga tgaagtactt   1740
gaccttgaag ctgctggtgt gaaaatcatc caaatcgacg aggctgctct tcgtgaaaaa   1800
ttgccactcc gccgtagcga ctggtacgaa gactaccttg actgggctat tcctgccttc   1860
cgcttggtac actcaacagt agcgccagac acacaaatcc acactcacat gtgttactca   1920
gaatttacag atatcatccc agctatcgat aacatggatg cagacgttat ttcctttgaa   1980
gctaaccgtt caaaccttga aatcttggac gaactcaaag cgaaaaactt ccaaacagaa   2040
gtgggacctg gggtttacga tatccactca cctcgtgtac caaatgaagg cgaaatcgac   2100
aacacaatcg aagccatcct tgctaaagtg ccaagcaaga aagtttggat caaccctgac   2160
tgtggtttga aaacacgtgg tatcccagaa acaaaagaaa gcttgatccg ccttgttgaa   2220
gcagctaaag ctgcgcgtga gaaattg                                       2247

<210>   1058
<211>   749
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902558 (0.E+01)


<400>   1058
Met Ser Thr Thr Ile Ile Gly Phe Pro Arg Leu Gly Glu Phe Arg Glu 
1               5                   10                  15      

Leu Lys Phe Thr Thr Glu Lys Tyr Phe Arg Lys Glu Ile Ser Glu Glu 
            20                  25                  30          

Glu Leu Leu Ala Ala Ala Lys Asp Leu Arg Ala Lys His Trp Asn Ile 
        35                  40                  45              

Val Lys Glu Lys Gly Ile Thr Glu Ile Pro Ser Asn Asp Phe Ser His 
    50                  55                  60                  

Tyr Asp Asn Phe Leu Asp Ala Ala Phe Leu Phe Asn Val Val Pro Ala 
65                  70                  75                  80  

Ser Val Gln Asn Leu Asp Leu Ser Asp Leu Glu Arg Tyr Phe Ala Leu 
                85                  90                  95      

Gly Arg Gly Tyr Gln Gly Glu Lys Gly Asp Val Arg Ala Leu Pro Met 
            100                 105                 110         

Lys Lys Trp Phe Asn Thr Asn Tyr His Tyr Ile Val Pro Lys Phe Glu 
        115                 120                 125             

Lys Asp Thr Gln Val Lys Leu Ala Gly His Lys Ile Phe Asp Glu Phe 
    130                 135                 140                 

Gln Glu Ala Lys Glu Leu Gly Leu Asn Thr Arg Pro Val Leu Val Gly 
145                 150                 155                 160 

Pro Phe Thr Phe Leu Gln Leu Ser Asp Phe Glu Glu Gly Val Lys Ala 
                165                 170                 175     

Asp Asp Phe Val Asp Ser Leu Val Ala Ala Tyr Gln Glu Val Phe Ala 
            180                 185                 190         

Lys Leu Ala Glu Leu Gly Ala Thr Arg Ile Gln Leu Asp Glu Ala Ala 
        195                 200                 205             

Leu Val Lys Asp Leu Thr Ala Glu Glu Lys Ala Leu Phe Leu Asn Leu 
    210                 215                 220                 

Tyr Asn Lys Leu Leu Ala Asp Lys Lys Gly Leu Glu Val Leu Leu Gln 
225                 230                 235                 240 

Thr Tyr Phe Gly Asp Val Arg Asp Val Tyr Ala Asp Leu Val Asn Leu 
                245                 250                 255     

Pro Val Asp Ala Ile Gly Leu Asp Phe Val Glu Gly Lys Lys Thr Leu 
            260                 265                 270         

Glu Leu Val Lys Gly Gly Phe Pro Ala Asp Lys Thr Leu Tyr Val Gly 
        275                 280                 285             

Ile Val Asn Gly Lys Asn Ile Trp Arg Asn Asn Tyr Glu Lys Ser Leu 
    290                 295                 300                 


Ala Val Leu Glu Gln Ile Pro Ala Glu Asn Ile Val Leu Thr Ser Ser 
305                 310                 315                 320 

Cys Ser Leu Leu His Val Pro Phe Thr Thr Ala Asn Glu Glu Phe Glu 
                325                 330                 335     

Pro Ala Leu Leu Asn His Phe Ala Phe Ala Val Glu Lys Leu Asp Glu 
            340                 345                 350         

Ile Arg Asp Leu Asp Ala Ile Arg Asn Gly Gln Gly Ser Glu Ala Leu 
        355                 360                 365             

Ala Ala Asn Lys Glu Leu Phe Ala Thr Glu Arg Val Gly Glu Asn Ala 
    370                 375                 380                 

Glu Leu Arg Ala Arg Ile Ala Gly Leu Thr Asp Ala Asp Tyr Thr Arg 
385                 390                 395                 400 

Leu Pro Ala Phe Ala Glu Arg Glu Ala Ile Gln Glu Glu Ala Phe Lys 
                405                 410                 415     

Leu Pro Ala Leu Pro Thr Thr Thr Ile Gly Ser Phe Pro Gln Thr Lys 
            420                 425                 430         

Glu Val Arg Ala Lys Arg Leu Ala Tyr Arg Lys Gly Glu Leu Ser Gln 
        435                 440                 445             

Lys Glu Tyr Asp Ala Phe Leu Ala Glu Thr Ile Asp Glu Trp Ile Lys 
    450                 455                 460                 

Trp Gln Glu Asp Ile Asp Phe Asp Val Leu Val His Gly Glu Phe Glu 
465                 470                 475                 480 

Arg Asn Asp Met Val Glu Tyr Phe Gly Gln Asn Leu Ser Gly Tyr Leu 
                485                 490                 495     

Phe Ser Lys Asn Gly Trp Val Gln Ser Tyr Gly Met Arg Gly Val Lys 
            500                 505                 510         

Pro Pro Ile Ile Trp Gly Asp Val Thr Arg Leu Asn Pro Ile Thr Val 
        515                 520                 525             

Lys Trp Ser Ser Tyr Ala Gln Ser Arg Thr Asn Lys Pro Val Lys Gly 
    530                 535                 540                 

Met Leu Thr Gly Pro Val Thr Ile Leu Asn Trp Ser Phe Pro Arg Glu 
545                 550                 555                 560 

Asp Ile Ser Ile Lys Asp Ser Thr Leu Gln Ile Ala Leu Ala Ile Lys 
                565                 570                 575     

Asp Glu Val Leu Asp Leu Glu Ala Ala Gly Val Lys Ile Ile Gln Ile 
            580                 585                 590         

Asp Glu Ala Ala Leu Arg Glu Lys Leu Pro Leu Arg Arg Ser Asp Trp 
        595                 600                 605             

Tyr Glu Asp Tyr Leu Asp Trp Ala Ile Pro Ala Phe Arg Leu Val His 
    610                 615                 620                 

Ser Thr Val Ala Pro Asp Thr Gln Ile His Thr His Met Cys Tyr Ser 
625                 630                 635                 640 

Glu Phe Thr Asp Ile Ile Pro Ala Ile Asp Asn Met Asp Ala Asp Val 
                645                 650                 655     

Ile Ser Phe Glu Ala Asn Arg Ser Asn Leu Glu Ile Leu Asp Glu Leu 
            660                 665                 670         

Lys Ala Lys Asn Phe Gln Thr Glu Val Gly Pro Gly Val Tyr Asp Ile 
        675                 680                 685             

His Ser Pro Arg Val Pro Asn Glu Gly Glu Ile Asp Asn Thr Ile Glu 
    690                 695                 700                 

Ala Ile Leu Ala Lys Val Pro Ser Lys Lys Val Trp Ile Asn Pro Asp 
705                 710                 715                 720 

Cys Gly Leu Lys Thr Arg Gly Ile Pro Glu Thr Lys Glu Ser Leu Ile 
                725                 730                 735     

Arg Leu Val Glu Ala Ala Lys Ala Ala Arg Glu Lys Leu 
            740                 745                 

<210>   1059
<211>   864
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1059
atgtcacgcc aaacaccgtc actctcattt gaagtgttcc ctccaaaccc agccgtgggt   60
aatgataaca ttatttcagc cttgcaggat atgcaggagt tggctcccca ttttatcagt   120
gtaactgcca gcaataataa atttaatatc aaggaaacga cggttcgttt ggctgacttt   180
atccaaaatg atttggcgat tccgaccatt gcccacttgc cagctattta tctaactaag   240
gacaaggttg ctgaaactat tgctgacttg gacaaagttg gggtgcagaa aatcttggct   300
cttcgtgggg atattattcc agacgtggaa ccacaaaagg atttccgcta tgcaaccgac   360
ttgattgagt ttatcaagga acaaacccct cactttgata ttattggagc ttgctatcca   420
gaagggcatc cagattcgcc aaatcagatt tcagatattc aaaatcttaa gaagaaagtg   480
gatgcaggct gttcgagcct cgtaactcag ctcttctttg acaatgagcg cttctatgat   540
tttcaggaca agtgtatctt ggctgggatt gatgttccca ttcatgcagg aattatgcca   600
attctgaatc gaaatcaggc tctccgactc ttgaagactt gtgagaatat ccatcttcca   660
cgcaaattta aagccatctt agacaagtat gagcatgacc ctgagtcgct cagagcagca   720
ggacttgcct atgcagtgga ccaaatcgtg gacttggtaa ctcaggatgt tgccggtgtg   780
catctctata cgatgaataa tgctgataca gcaaaataca tccatcaagc aacccatgcc   840
ttgtttaatc accagtctct agga                                          864

<210>   1060
<211>   288
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   5,10-methylenetetrahydrofolate reductase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902559 (e-165)

<400>   1060
Met Ser Arg Gln Thr Pro Ser Leu Ser Phe Glu Val Phe Pro Pro Asn 
1               5                   10                  15      

Pro Ala Val Gly Asn Asp Asn Ile Ile Ser Ala Leu Gln Asp Met Gln 
            20                  25                  30          

Glu Leu Ala Pro His Phe Ile Ser Val Thr Ala Ser Asn Asn Lys Phe 
        35                  40                  45              

Asn Ile Lys Glu Thr Thr Val Arg Leu Ala Asp Phe Ile Gln Asn Asp 
    50                  55                  60                  

Leu Ala Ile Pro Thr Ile Ala His Leu Pro Ala Ile Tyr Leu Thr Lys 
65                  70                  75                  80  

Asp Lys Val Ala Glu Thr Ile Ala Asp Leu Asp Lys Val Gly Val Gln 
                85                  90                  95      

Lys Ile Leu Ala Leu Arg Gly Asp Ile Ile Pro Asp Val Glu Pro Gln 
            100                 105                 110         

Lys Asp Phe Arg Tyr Ala Thr Asp Leu Ile Glu Phe Ile Lys Glu Gln 
        115                 120                 125             

Thr Pro His Phe Asp Ile Ile Gly Ala Cys Tyr Pro Glu Gly His Pro 
    130                 135                 140                 

Asp Ser Pro Asn Gln Ile Ser Asp Ile Gln Asn Leu Lys Lys Lys Val 
145                 150                 155                 160 

Asp Ala Gly Cys Ser Ser Leu Val Thr Gln Leu Phe Phe Asp Asn Glu 
                165                 170                 175     

Arg Phe Tyr Asp Phe Gln Asp Lys Cys Ile Leu Ala Gly Ile Asp Val 
            180                 185                 190         

Pro Ile His Ala Gly Ile Met Pro Ile Leu Asn Arg Asn Gln Ala Leu 
        195                 200                 205             

Arg Leu Leu Lys Thr Cys Glu Asn Ile His Leu Pro Arg Lys Phe Lys 
    210                 215                 220                 

Ala Ile Leu Asp Lys Tyr Glu His Asp Pro Glu Ser Leu Arg Ala Ala 
225                 230                 235                 240 

Gly Leu Ala Tyr Ala Val Asp Gln Ile Val Asp Leu Val Thr Gln Asp 
                245                 250                 255     

Val Ala Gly Val His Leu Tyr Thr Met Asn Asn Ala Asp Thr Ala Lys 
            260                 265                 270         

Tyr Ile His Gln Ala Thr His Ala Leu Phe Asn His Gln Ser Leu Gly 
        275                 280                 285             


<210>   1061
<211>   267
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1061
gtgctaggaa gcttatcttt tttcctaaga aatgagacca aaattcaagt catcaagata   60
ccaagccgtc aagcaactca aaggaagata ggaaatcgaa cgacggagcg actactccta   120
gggagattta tctttttcca cagagttgta ggcaagttca gttttcaaga tacatcatta   180
gaaaggttta atactaaagt atctaaagct ttcacgctaa tcgctatcgg gcgattagct   240
aaatgcttta ctaactctct cgtcaaa                                       267

<210>   1062
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1062
Met Leu Gly Ser Leu Ser Phe Phe Leu Arg Asn Glu Thr Lys Ile Gln 
1               5                   10                  15      

Val Ile Lys Ile Pro Ser Arg Gln Ala Thr Gln Arg Lys Ile Gly Asn 
            20                  25                  30          

Arg Thr Thr Glu Arg Leu Leu Leu Gly Arg Phe Ile Phe Phe His Arg 
        35                  40                  45              

Val Val Gly Lys Phe Ser Phe Gln Asp Thr Ser Leu Glu Arg Phe Asn 
    50                  55                  60                  

Thr Lys Val Ser Lys Ala Phe Thr Leu Ile Ala Ile Gly Arg Leu Ala 
65                  70                  75                  80  

Lys Cys Phe Thr Asn Ser Leu Val Lys 
                85                  

<210>   1063
<211>   2211
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1063
atggcaaaac aagtgtttca aacgactttt gcgggtcgtg agttaattgt agagactggt   60
caggttgcta agcaagcaaa tggatctgtt gtcgtacgtt acggtgagtc aactgtcttg   120
actgctgccg ttatgtctaa gaaaatggca actggggatt tcttcccact ccaagtcaac   180
tacgaagaaa aaatgtatgc ggctgggaag tttcctggtg gctttatgaa acgtgaagga   240
cgtccttcaa cagatgcgac cttgacagcg cgtttgattg accgtccgat tcgtcctatg   300
tttgcggaag gtttccgtaa tgaagtccaa gtcatcaata cagtgctttc ttatgatgaa   360
aatgcatctg caccaatggc tgctatgttt ggttcatctt tggcactgtc tatttcagat   420
attccatttg acggaccaat tgctggggta caagtgggat atgtagatgg ccaaatcatc   480
atcaacccaa gtcaagaaca agcagagcaa tctcttcttg aattgacagt agctggaacc   540
aagcacgcta tcaacatggt agagtctggt gccaaagaat tgtcagaaga aatcatgttg   600
gaagcgctcc ttaaagggca cgaagctgtc aaagaattga ttgccttcca agaagaaatc   660
gttgctgctg tcggtaaaga aaaagcagaa gtggaattgc ttcacgtgga tgctgaattg   720
caagctgaaa tcattgcagc ctacaacagt gacctccaaa aggcagttca agtagaagag   780
aaattggccc gtgaagctgc gactcaagta gtgaaagacc aagtgactgc cgtttacgaa   840
gaaaaatatg cggaccacga agaatttgac cgtattatgc gtgatgtggc tgaaatcttg   900
gaacaaatgg aacacgcaga agtgcgacgt ttaattacag aagacaaggt gcgtcctgat   960
ggtcgtaagg tcgatgaaat ccgtcctttg gatgcggttg ttgacttcct tcctcgtgta   1020
catggttcag gtctctttac tcgtgggcaa actcaagctc tttcagtctt gaccttggct   1080
ccgatgggag aaactcaaat cattgatggt ttggatccag agtacaagaa acgctttatg   1140
caccactata acttccctca atattctgta ggggaaacag gtcgttacgg tgcgccaggt   1200
cgtcgtgaaa tcggtcacgg tgcccttggt gagcgtgctc ttgctcaagt cttgccaagc   1260
ttggaagaat tcccctacgc tatccgtcta gtagcagaag ttttggaatc aaacggttct   1320
tcatctcaag cttctatctg tgcgggaact cttgccctta tggctggtgg tgtgccaatc   1380
aaggcgccag tagctggtat tgctatgggg cttatctcag atggaaataa ctacacagta   1440
ttgacagata tccaaggttt ggaagatcac tttggagata tggacttcaa ggttgcaggt   1500
actcgtgatg ggattacagc ccttcaaatg gatatcaaga ttcaagggat tactgcagaa   1560
atcttgacgg aggctcttgc tcaagccaag aaagcgcgtt ttgaaatcct tgatgtcatt   1620
gaagcaacca ttccagaagt tcgtccagaa ttggctccaa ctgctccgaa aattgatacg   1680
atcaagattg atgtggacaa gattaagatt gtcatcggta agggtggaga aaccatcgac   1740
aagattatcg ctgaaacagg tgttaagatt gatatagacg aagaaggaaa tgtgtctatc   1800
tactctagtg accaagatgc tattaaccgt gccaaagaaa ttattgctgg tttggttcgt   1860
gaagccaaag tggatgaagt ttaccgtgct aaagtcgttc gtatcgagaa atttggtgcc   1920
tttgttaacc tctttgataa gacagatgcc cttgttcata tctctgagat ggcttggact   1980
cgtaccaatc gtgtagagga tttggtagaa atcggggatg aagttgatgt taaggttatc   2040
aaaattgatg aaaaaggccg tatcgatgcc tctatgaagg ctcttctacc tcgtccgcca   2100
aaacctgagc atgatgaaaa aggtgaaaag tctgagcgcc ctcaccgccc acgtcatcaa   2160
aaggattaca aacctaagaa agaatttaca gaaacatcaa aagattcaga a            2211

<210>   1064
<211>   737
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   polyribonucleotide nucleotidyltransferase (pnp)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902560 (0.E+01)

<400>   1064
Met Ala Lys Gln Val Phe Gln Thr Thr Phe Ala Gly Arg Glu Leu Ile 
1               5                   10                  15      

Val Glu Thr Gly Gln Val Ala Lys Gln Ala Asn Gly Ser Val Val Val 
            20                  25                  30          

Arg Tyr Gly Glu Ser Thr Val Leu Thr Ala Ala Val Met Ser Lys Lys 
        35                  40                  45              

Met Ala Thr Gly Asp Phe Phe Pro Leu Gln Val Asn Tyr Glu Glu Lys 
    50                  55                  60                  

Met Tyr Ala Ala Gly Lys Phe Pro Gly Gly Phe Met Lys Arg Glu Gly 
65                  70                  75                  80  

Arg Pro Ser Thr Asp Ala Thr Leu Thr Ala Arg Leu Ile Asp Arg Pro 
                85                  90                  95      

Ile Arg Pro Met Phe Ala Glu Gly Phe Arg Asn Glu Val Gln Val Ile 
            100                 105                 110         

Asn Thr Val Leu Ser Tyr Asp Glu Asn Ala Ser Ala Pro Met Ala Ala 
        115                 120                 125             

Met Phe Gly Ser Ser Leu Ala Leu Ser Ile Ser Asp Ile Pro Phe Asp 
    130                 135                 140                 

Gly Pro Ile Ala Gly Val Gln Val Gly Tyr Val Asp Gly Gln Ile Ile 
145                 150                 155                 160 

Ile Asn Pro Ser Gln Glu Gln Ala Glu Gln Ser Leu Leu Glu Leu Thr 
                165                 170                 175     

Val Ala Gly Thr Lys His Ala Ile Asn Met Val Glu Ser Gly Ala Lys 
            180                 185                 190         

Glu Leu Ser Glu Glu Ile Met Leu Glu Ala Leu Leu Lys Gly His Glu 
        195                 200                 205             

Ala Val Lys Glu Leu Ile Ala Phe Gln Glu Glu Ile Val Ala Ala Val 
    210                 215                 220                 

Gly Lys Glu Lys Ala Glu Val Glu Leu Leu His Val Asp Ala Glu Leu 
225                 230                 235                 240 

Gln Ala Glu Ile Ile Ala Ala Tyr Asn Ser Asp Leu Gln Lys Ala Val 
                245                 250                 255     

Gln Val Glu Glu Lys Leu Ala Arg Glu Ala Ala Thr Gln Val Val Lys 
            260                 265                 270         

Asp Gln Val Thr Ala Val Tyr Glu Glu Lys Tyr Ala Asp His Glu Glu 
        275                 280                 285             

Phe Asp Arg Ile Met Arg Asp Val Ala Glu Ile Leu Glu Gln Met Glu 
    290                 295                 300                 

His Ala Glu Val Arg Arg Leu Ile Thr Glu Asp Lys Val Arg Pro Asp 
305                 310                 315                 320 

Gly Arg Lys Val Asp Glu Ile Arg Pro Leu Asp Ala Val Val Asp Phe 
                325                 330                 335     

Leu Pro Arg Val His Gly Ser Gly Leu Phe Thr Arg Gly Gln Thr Gln 
            340                 345                 350         

Ala Leu Ser Val Leu Thr Leu Ala Pro Met Gly Glu Thr Gln Ile Ile 
        355                 360                 365             

Asp Gly Leu Asp Pro Glu Tyr Lys Lys Arg Phe Met His His Tyr Asn 
    370                 375                 380                 

Phe Pro Gln Tyr Ser Val Gly Glu Thr Gly Arg Tyr Gly Ala Pro Gly 
385                 390                 395                 400 

Arg Arg Glu Ile Gly His Gly Ala Leu Gly Glu Arg Ala Leu Ala Gln 
                405                 410                 415     

Val Leu Pro Ser Leu Glu Glu Phe Pro Tyr Ala Ile Arg Leu Val Ala 
            420                 425                 430         

Glu Val Leu Glu Ser Asn Gly Ser Ser Ser Gln Ala Ser Ile Cys Ala 
        435                 440                 445             

Gly Thr Leu Ala Leu Met Ala Gly Gly Val Pro Ile Lys Ala Pro Val 
    450                 455                 460                 

Ala Gly Ile Ala Met Gly Leu Ile Ser Asp Gly Asn Asn Tyr Thr Val 
465                 470                 475                 480 

Leu Thr Asp Ile Gln Gly Leu Glu Asp His Phe Gly Asp Met Asp Phe 
                485                 490                 495     

Lys Val Ala Gly Thr Arg Asp Gly Ile Thr Ala Leu Gln Met Asp Ile 
            500                 505                 510         

Lys Ile Gln Gly Ile Thr Ala Glu Ile Leu Thr Glu Ala Leu Ala Gln 
        515                 520                 525             

Ala Lys Lys Ala Arg Phe Glu Ile Leu Asp Val Ile Glu Ala Thr Ile 
    530                 535                 540                 

Pro Glu Val Arg Pro Glu Leu Ala Pro Thr Ala Pro Lys Ile Asp Thr 
545                 550                 555                 560 

Ile Lys Ile Asp Val Asp Lys Ile Lys Ile Val Ile Gly Lys Gly Gly 
                565                 570                 575     

Glu Thr Ile Asp Lys Ile Ile Ala Glu Thr Gly Val Lys Ile Asp Ile 
            580                 585                 590         

Asp Glu Glu Gly Asn Val Ser Ile Tyr Ser Ser Asp Gln Asp Ala Ile 
        595                 600                 605             

Asn Arg Ala Lys Glu Ile Ile Ala Gly Leu Val Arg Glu Ala Lys Val 
    610                 615                 620                 

Asp Glu Val Tyr Arg Ala Lys Val Val Arg Ile Glu Lys Phe Gly Ala 
625                 630                 635                 640 

Phe Val Asn Leu Phe Asp Lys Thr Asp Ala Leu Val His Ile Ser Glu 
                645                 650                 655     

Met Ala Trp Thr Arg Thr Asn Arg Val Glu Asp Leu Val Glu Ile Gly 
            660                 665                 670         

Asp Glu Val Asp Val Lys Val Ile Lys Ile Asp Glu Lys Gly Arg Ile 
        675                 680                 685             

Asp Ala Ser Met Lys Ala Leu Leu Pro Arg Pro Pro Lys Pro Glu His 
    690                 695                 700                 

Asp Glu Lys Gly Glu Lys Ser Glu Arg Pro His Arg Pro Arg His Gln 
705                 710                 715                 720 

Lys Asp Tyr Lys Pro Lys Lys Glu Phe Thr Glu Thr Ser Lys Asp Ser 
                725                 730                 735     

Glu 
    

<210>   1065
<211>   615
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1065
atggggtggt ggcgcgaaac cattgatatt gtaaaagaaa atgatccagc ggcccgcacc   60
actttggagg ttttgctgac ttatccaggt gtcaaggcct tggcggccca ccgtctctcg   120
cattttctct ggaagcacgg cttcaaacta ttagctcgta tgtacagtca gttttggcgc   180
ttttggactc agattgagat tcatccagga gcccagattg attcaggtgt ttttattgac   240
catggttctg gtctggtgat tggagagaca gcgattgttg aaaaaggcgt tcttctctat   300
cacggagtga ctctcggggg aacagggaaa gactgtggca aacgccatcc gactgtacga   360
aagggagccc tcatatcagc ccatgcccaa gttatcgggc ctgtggaaat tggtgaaaat   420
gccaaggtcg gtgctgcagc agttgtcgta gcagatgtac ctagtgacgt gacggttgtc   480
ggtattccgg ccaagattgt ccgtcttcat ggtaagaaag atgagcctgt cattcacgaa   540
gtcgaagaaa aacgagagta ttatgtcaat aaactcgagc aggctaaaga tgccagtcac   600
agatcgtctg gtttg                                                    615

<210>   1066
<211>   205
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   serine acetyltransferase (cysE)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902561 (e-119)

<400>   1066
Met Gly Trp Trp Arg Glu Thr Ile Asp Ile Val Lys Glu Asn Asp Pro 
1               5                   10                  15      

Ala Ala Arg Thr Thr Leu Glu Val Leu Leu Thr Tyr Pro Gly Val Lys 
            20                  25                  30          

Ala Leu Ala Ala His Arg Leu Ser His Phe Leu Trp Lys His Gly Phe 
        35                  40                  45              

Lys Leu Leu Ala Arg Met Tyr Ser Gln Phe Trp Arg Phe Trp Thr Gln 
    50                  55                  60                  

Ile Glu Ile His Pro Gly Ala Gln Ile Asp Ser Gly Val Phe Ile Asp 
65                  70                  75                  80  

His Gly Ser Gly Leu Val Ile Gly Glu Thr Ala Ile Val Glu Lys Gly 
                85                  90                  95      

Val Leu Leu Tyr His Gly Val Thr Leu Gly Gly Thr Gly Lys Asp Cys 
            100                 105                 110         

Gly Lys Arg His Pro Thr Val Arg Lys Gly Ala Leu Ile Ser Ala His 
        115                 120                 125             

Ala Gln Val Ile Gly Pro Val Glu Ile Gly Glu Asn Ala Lys Val Gly 
    130                 135                 140                 

Ala Ala Ala Val Val Val Ala Asp Val Pro Ser Asp Val Thr Val Val 
145                 150                 155                 160 

Gly Ile Pro Ala Lys Ile Val Arg Leu His Gly Lys Lys Asp Glu Pro 
                165                 170                 175     

Val Ile His Glu Val Glu Glu Lys Arg Glu Tyr Tyr Val Asn Lys Leu 
            180                 185                 190         

Glu Gln Ala Lys Asp Ala Ser His Arg Ser Ser Gly Leu 
        195                 200                 205 

<210>   1067
<211>   882
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1067
atgattcaag caagaaacaa gttaagccaa gaggagctat ctgaggcgaa aaaagtaatt   60
aactgttgcc aaaactatga cggtacctat cgcgatccct atctctctaa catgcttaat   120
tttgacccaa acatgcccgc ctttttcctt tattatgaaa aaggcgaact tgttggttta   180
ttaactgtct atgcagatga ccaagatgta gaagtgacga tactggttca tccaggtcat   240
cgccgtcagg ggattgcgcg tgcattgttt actagttttg agagagaaac agcttctttc   300
cccattcggt cagtcacttt tcagacagaa cgtatttttt tagagaatca tcctgacttt   360
gccagtaact ggggactaat cgaggatgaa gagacagaaa cttggttagg taaggataga   420
agaccttatc cgttagcaaa tgtttcccat cttgaagttt tgttagcaga tagttcgtat   480
caggatcaaa ttagtcaatt aaaatttcag gcattttcag aggaacatga atcgagagaa   540
gttgtggata gatatgtcgc tgaagctctg aaagatccag aaagccgact atatatttta   600
ttaaaagctg gtcaggttat tggaacttgt acggttgatt tatcgactaa tacgaattac   660
ctctacggtt tagcaatatt ggaacctgaa cgtggaaaag gctatggaag ctacttagca   720
aaatccctcg tcaaccaact aattgagcaa aatgacaagg aatttcagat tgcagtggaa   780
gatagcaatg taggtgccaa acgtttgtat gaaaaaattg gctttgtcaa acagactcag   840
gtggtttatc tgaatgagaa aggagcaagg gattccgaag tg                      882

<210>   1068
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902562 (e-169)

<400>   1068
Met Ile Gln Ala Arg Asn Lys Leu Ser Gln Glu Glu Leu Ser Glu Ala 
1               5                   10                  15      

Lys Lys Val Ile Asn Cys Cys Gln Asn Tyr Asp Gly Thr Tyr Arg Asp 
            20                  25                  30          

Pro Tyr Leu Ser Asn Met Leu Asn Phe Asp Pro Asn Met Pro Ala Phe 
        35                  40                  45              

Phe Leu Tyr Tyr Glu Lys Gly Glu Leu Val Gly Leu Leu Thr Val Tyr 
    50                  55                  60                  

Ala Asp Asp Gln Asp Val Glu Val Thr Ile Leu Val His Pro Gly His 
65                  70                  75                  80  

Arg Arg Gln Gly Ile Ala Arg Ala Leu Phe Thr Ser Phe Glu Arg Glu 
                85                  90                  95      

Thr Ala Ser Phe Pro Ile Arg Ser Val Thr Phe Gln Thr Glu Arg Ile 
            100                 105                 110         

Phe Leu Glu Asn His Pro Asp Phe Ala Ser Asn Trp Gly Leu Ile Glu 
        115                 120                 125             

Asp Glu Glu Thr Glu Thr Trp Leu Gly Lys Asp Arg Arg Pro Tyr Pro 
    130                 135                 140                 

Leu Ala Asn Val Ser His Leu Glu Val Leu Leu Ala Asp Ser Ser Tyr 
145                 150                 155                 160 

Gln Asp Gln Ile Ser Gln Leu Lys Phe Gln Ala Phe Ser Glu Glu His 
                165                 170                 175     

Glu Ser Arg Glu Val Val Asp Arg Tyr Val Ala Glu Ala Leu Lys Asp 
            180                 185                 190         

Pro Glu Ser Arg Leu Tyr Ile Leu Leu Lys Ala Gly Gln Val Ile Gly 
        195                 200                 205             

Thr Cys Thr Val Asp Leu Ser Thr Asn Thr Asn Tyr Leu Tyr Gly Leu 
    210                 215                 220                 

Ala Ile Leu Glu Pro Glu Arg Gly Lys Gly Tyr Gly Ser Tyr Leu Ala 
225                 230                 235                 240 

Lys Ser Leu Val Asn Gln Leu Ile Glu Gln Asn Asp Lys Glu Phe Gln 
                245                 250                 255     

Ile Ala Val Glu Asp Ser Asn Val Gly Ala Lys Arg Leu Tyr Glu Lys 
            260                 265                 270         


Ile Gly Phe Val Lys Gln Thr Gln Val Val Tyr Leu Asn Glu Lys Gly 
        275                 280                 285             

Ala Arg Asp Ser Glu Val 
    290                 

<210>   1069
<211>   1341
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1069
atgattaaaa tctatgacac catgtctcgt gatttgcgag aatttgtccc gattgaggac   60
ggcaagatca agatgtatgt ttgtgggcca acggtgtaca actatatcca cgtaggaaac   120
gcccgttcga cggtagcttt tgatacgatt cgtcgctatt ttgagtaccg tgggtataag   180
gttgcctata tttccaattt tacagatgtg gatgataaga ttatcaaccg tgccagggaa   240
gaaggtatca cgcctcagga ggttgcggat aagtacatcg ctgcctttcg tgaggatgtg   300
acggcattgg gcgtgaaacc tgcgactcgc catccgcgtg tagtggagtt tatggcagac   360
atcatccgtt ttgtggaaga cttgatcgag aaaggctttg cctatgagag tcaaggggat   420
gtctatttcc gtgtagaaaa atcccacaac tatgctaaat tggctaataa aaccttggaa   480
gatttggagc taggtgcttc aggtcgtacc gatgaagaaa cggctcgtaa ggaaaatcct   540
gtagactttg ctctatggaa atcttccaaa ccaggtgaga tttcttggga tagtccttgg   600
ggacctggac gtccgggttg gcatattgag tgttcagtca tgtcgacaga gattttaggt   660
gataccattg atatccacgg tggtggagct gacctagagt ttccacacca caccaatgaa   720
attgcccagt ctgaagctaa aacaggcaag gcttttgcta actactggat gcacaatggc   780
tttgtcaata tcgacaatgt caaaatgtct aagtccttgg gtaacttcat tacggtacac   840
gatgccctta aaactcttga tgggcaagta cttcgtttct tctttgcgac ccagcactac   900
cgtaagccta tcaacttcac ggaaaaggca gttcgcgatg ccgagaccaa tctcaagtat   960
ctcaagaata cttacgaaca accatttaca ggaaatgtgg atgcccaaga gttacaaaac   1020
tttaaagata agtttgtagc agctatggat gaagatttta atgctgccaa cggtatcaca   1080
gttgtctttg aaatggccaa atggatcaac tcagggaact atgatgcaag tgtcaagcaa   1140
gctcttgcag atatgttaga aatttttgga attgtctttg ttgaggaagt tttggatgca   1200
gagattgaag acttgattca aaaacgccaa gaggcgcgtg ccaatcgtga ctttgcgaca   1260
gcagaccaaa tccgtgacca attggttact caaggaatta agctccttga taccaaggat   1320
ggagtgaggt ggacacgtga t                                             1341

<210>   1070
<211>   447
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cysteinyl-tRNA synthetase (cysS)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902563 (0.E+01)

<400>   1070
Met Ile Lys Ile Tyr Asp Thr Met Ser Arg Asp Leu Arg Glu Phe Val 
1               5                   10                  15      

Pro Ile Glu Asp Gly Lys Ile Lys Met Tyr Val Cys Gly Pro Thr Val 
            20                  25                  30          

Tyr Asn Tyr Ile His Val Gly Asn Ala Arg Ser Thr Val Ala Phe Asp 
        35                  40                  45              

Thr Ile Arg Arg Tyr Phe Glu Tyr Arg Gly Tyr Lys Val Ala Tyr Ile 
    50                  55                  60                  

Ser Asn Phe Thr Asp Val Asp Asp Lys Ile Ile Asn Arg Ala Arg Glu 
65                  70                  75                  80  

Glu Gly Ile Thr Pro Gln Glu Val Ala Asp Lys Tyr Ile Ala Ala Phe 
                85                  90                  95      

Arg Glu Asp Val Thr Ala Leu Gly Val Lys Pro Ala Thr Arg His Pro 
            100                 105                 110         

Arg Val Val Glu Phe Met Ala Asp Ile Ile Arg Phe Val Glu Asp Leu 
        115                 120                 125             

Ile Glu Lys Gly Phe Ala Tyr Glu Ser Gln Gly Asp Val Tyr Phe Arg 
    130                 135                 140                 

Val Glu Lys Ser His Asn Tyr Ala Lys Leu Ala Asn Lys Thr Leu Glu 
145                 150                 155                 160 

Asp Leu Glu Leu Gly Ala Ser Gly Arg Thr Asp Glu Glu Thr Ala Arg 
                165                 170                 175     

Lys Glu Asn Pro Val Asp Phe Ala Leu Trp Lys Ser Ser Lys Pro Gly 
            180                 185                 190         

Glu Ile Ser Trp Asp Ser Pro Trp Gly Pro Gly Arg Pro Gly Trp His 
        195                 200                 205             

Ile Glu Cys Ser Val Met Ser Thr Glu Ile Leu Gly Asp Thr Ile Asp 
    210                 215                 220                 

Ile His Gly Gly Gly Ala Asp Leu Glu Phe Pro His His Thr Asn Glu 
225                 230                 235                 240 

Ile Ala Gln Ser Glu Ala Lys Thr Gly Lys Ala Phe Ala Asn Tyr Trp 
                245                 250                 255     

Met His Asn Gly Phe Val Asn Ile Asp Asn Val Lys Met Ser Lys Ser 
            260                 265                 270         

Leu Gly Asn Phe Ile Thr Val His Asp Ala Leu Lys Thr Leu Asp Gly 
        275                 280                 285             

Gln Val Leu Arg Phe Phe Phe Ala Thr Gln His Tyr Arg Lys Pro Ile 
    290                 295                 300                 

Asn Phe Thr Glu Lys Ala Val Arg Asp Ala Glu Thr Asn Leu Lys Tyr 
305                 310                 315                 320 

Leu Lys Asn Thr Tyr Glu Gln Pro Phe Thr Gly Asn Val Asp Ala Gln 
                325                 330                 335     

Glu Leu Gln Asn Phe Lys Asp Lys Phe Val Ala Ala Met Asp Glu Asp 
            340                 345                 350         

Phe Asn Ala Ala Asn Gly Ile Thr Val Val Phe Glu Met Ala Lys Trp 
        355                 360                 365             

Ile Asn Ser Gly Asn Tyr Asp Ala Ser Val Lys Gln Ala Leu Ala Asp 
    370                 375                 380                 

Met Leu Glu Ile Phe Gly Ile Val Phe Val Glu Glu Val Leu Asp Ala 
385                 390                 395                 400 

Glu Ile Glu Asp Leu Ile Gln Lys Arg Gln Glu Ala Arg Ala Asn Arg 
                405                 410                 415     

Asp Phe Ala Thr Ala Asp Gln Ile Arg Asp Gln Leu Val Thr Gln Gly 
            420                 425                 430         

Ile Lys Leu Leu Asp Thr Lys Asp Gly Val Arg Trp Thr Arg Asp 
        435                 440                 445         

<210>   1071
<211>   384
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1071
gtgattgatg tcaatctcat taacgggatt gcgctagcct ttgaggggga tgcggtgtat   60
tctatgtata ttcgccgtca cctcatcctc aaaggtatga ccaaacccaa taaactccat   120
caagaagcaa ctaagtacgt gtcagccaag gctcaggctc gcctgattgc tctcatgttg   180
gaggagcagg tcctaacgga aaaagaagaa gaaatctaca aacgtggccg caataccaat   240
agccacacaa aggctaaaaa tgcagatgtc gtgacttatc gtatgtccac gggatttgaa   300
gcggttatgg gctatctcca tatgactgag aatctggaac gtcttgagag tttggtttca   360
tggtgcatcc aaaaagtgga gggc                                          384

<210>   1072
<211>   128
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902564 (1.E-69)

<400>   1072
Met Ile Asp Val Asn Leu Ile Asn Gly Ile Ala Leu Ala Phe Glu Gly 
1               5                   10                  15      

Asp Ala Val Tyr Ser Met Tyr Ile Arg Arg His Leu Ile Leu Lys Gly 
            20                  25                  30          

Met Thr Lys Pro Asn Lys Leu His Gln Glu Ala Thr Lys Tyr Val Ser 
        35                  40                  45              

Ala Lys Ala Gln Ala Arg Leu Ile Ala Leu Met Leu Glu Glu Gln Val 
    50                  55                  60                  

Leu Thr Glu Lys Glu Glu Glu Ile Tyr Lys Arg Gly Arg Asn Thr Asn 
65                  70                  75                  80  

Ser His Thr Lys Ala Lys Asn Ala Asp Val Val Thr Tyr Arg Met Ser 
                85                  90                  95      

Thr Gly Phe Glu Ala Val Met Gly Tyr Leu His Met Thr Glu Asn Leu 
            100                 105                 110         

Glu Arg Leu Glu Ser Leu Val Ser Trp Cys Ile Gln Lys Val Glu Gly 
        115                 120                 125             


<210>   1073
<211>   882
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1073
atgagggcaa aagaactaca agactggttt cctgaggctc ggatttcaga ccaaccagta   60
gagaaagagg gctatctcac gctcccttta gcttctcagc agtggatttt gctggaggaa   120
gctgggctca gcgagcgtga aaagcagttg gttgcccttt tgacccagca ggagcaggct   180
cgttcgctaa acccttggta ttcctatctg gttgagggca agggacaggc accgcaagtt   240
tttaaaaaga ttcagttggt ttattgccat ctttcttatt ttcagcagga aaatctggct   300
tcttggctag atatgatgcg gactcttttt ccgaattgtc agacagtgct acaggtcgga   360
gctcaggatt atgttttcgt gcttcaacaa gacaaataca cttctgtaag agatatttta   420
agtgatacga ttgaagcggt tgagtatgac tttggacttc gtctttctat catgttgggt   480
caggtttggt ctcagacggg acatcaagcc ctatcagact taatcaaagc tgagcgggat   540
ttgttcaaga catggtggcg tcagggtcac caaggtgttc atactttttc tcagctctat   600
ctttggagta tgggagaaag actcgtggac ttgaagccaa tcaaggaatg tctacaccag   660
atgattttgg atcaagatca gattcaggaa atcattctct ctctttggga aaatagtgct   720
gttctcacta aaacagccca gcaactctat ctgcaccgca attctctcca atacaagatt   780
gataaatggg aagagttgac agggcttcag ttgaaagagt tgaccgacct gaccttgtgt   840
tatcaattga ttttaggttc tttgtcaact atagttggtt tg                      882

<210>   1074
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   leucine-rich protein (lrp)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902565 (e-170)

<400>   1074
Met Arg Ala Lys Glu Leu Gln Asp Trp Phe Pro Glu Ala Arg Ile Ser 
1               5                   10                  15      

Asp Gln Pro Val Glu Lys Glu Gly Tyr Leu Thr Leu Pro Leu Ala Ser 
            20                  25                  30          

Gln Gln Trp Ile Leu Leu Glu Glu Ala Gly Leu Ser Glu Arg Glu Lys 
        35                  40                  45              

Gln Leu Val Ala Leu Leu Thr Gln Gln Glu Gln Ala Arg Ser Leu Asn 
    50                  55                  60                  

Pro Trp Tyr Ser Tyr Leu Val Glu Gly Lys Gly Gln Ala Pro Gln Val 
65                  70                  75                  80  

Phe Lys Lys Ile Gln Leu Val Tyr Cys His Leu Ser Tyr Phe Gln Gln 
                85                  90                  95      

Glu Asn Leu Ala Ser Trp Leu Asp Met Met Arg Thr Leu Phe Pro Asn 
            100                 105                 110         

Cys Gln Thr Val Leu Gln Val Gly Ala Gln Asp Tyr Val Phe Val Leu 
        115                 120                 125             

Gln Gln Asp Lys Tyr Thr Ser Val Arg Asp Ile Leu Ser Asp Thr Ile 
    130                 135                 140                 

Glu Ala Val Glu Tyr Asp Phe Gly Leu Arg Leu Ser Ile Met Leu Gly 
145                 150                 155                 160 

Gln Val Trp Ser Gln Thr Gly His Gln Ala Leu Ser Asp Leu Ile Lys 
                165                 170                 175     

Ala Glu Arg Asp Leu Phe Lys Thr Trp Trp Arg Gln Gly His Gln Gly 
            180                 185                 190         

Val His Thr Phe Ser Gln Leu Tyr Leu Trp Ser Met Gly Glu Arg Leu 
        195                 200                 205             

Val Asp Leu Lys Pro Ile Lys Glu Cys Leu His Gln Met Ile Leu Asp 
    210                 215                 220                 

Gln Asp Gln Ile Gln Glu Ile Ile Leu Ser Leu Trp Glu Asn Ser Ala 
225                 230                 235                 240 

Val Leu Thr Lys Thr Ala Gln Gln Leu Tyr Leu His Arg Asn Ser Leu 
                245                 250                 255     

Gln Tyr Lys Ile Asp Lys Trp Glu Glu Leu Thr Gly Leu Gln Leu Lys 
            260                 265                 270         

Glu Leu Thr Asp Leu Thr Leu Cys Tyr Gln Leu Ile Leu Gly Ser Leu 
        275                 280                 285             

Ser Thr Ile Val Gly Leu 
    290                 

<210>   1075
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1075
gtgcagagtt atagtggctt gatgctggga aagtacactg tgactgctaa aacattccta   60
gaagctgctt tgatttccct aatctattta tgcaaatttt atgttatttt acta         114

<210>   1076
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein, fusion
<223>   Cellular location: membrane

<400>   1076
Met Gln Ser Tyr Ser Gly Leu Met Leu Gly Lys Tyr Thr Val Thr Ala 
1               5                   10                  15      

Lys Thr Phe Leu Glu Ala Ala Leu Ile Ser Leu Ile Tyr Leu Cys Lys 
            20                  25                  30          

Phe Tyr Val Ile Leu Leu 
        35              

<210>   1077
<211>   453
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1077
atgcaaattt tatgttattt tactataaca gttgttgcta agccaaataa tagtggggaa   60
gttcatttag acgtaagcat tgaagataat cagggaggta gtgggtataa tttcagttct   120
gtttcaagta gctcacaaac agctaaatat gaaggaactg tttataataa caattcatca   180
ttatatataa cgattgataa aacgtctgat gcaacagctc ttttgaaatt aaagttgaat   240
aatgttgata atcaacctgc tactgaagtt cctagttcag gaattactgt aaaattaaat   300
gctaaagata atgctggaaa ctggacaagt gcttcgaata aaaaagaagt aacagtaaaa   360
attgtttctg ctaaaccgac atatccagac aaaatcttag tgaaaaatcc tgataatata   420
aaagatacag aaaaaatgcc attattgaaa aat                                453

<210>   1078
<211>   151
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902566 (2.E-81)

<400>   1078
Met Gln Ile Leu Cys Tyr Phe Thr Ile Thr Val Val Ala Lys Pro Asn 
1               5                   10                  15      

Asn Ser Gly Glu Val His Leu Asp Val Ser Ile Glu Asp Asn Gln Gly 
            20                  25                  30          

Gly Ser Gly Tyr Asn Phe Ser Ser Val Ser Ser Ser Ser Gln Thr Ala 
        35                  40                  45              

Lys Tyr Glu Gly Thr Val Tyr Asn Asn Asn Ser Ser Leu Tyr Ile Thr 
    50                  55                  60                  

Ile Asp Lys Thr Ser Asp Ala Thr Ala Leu Leu Lys Leu Lys Leu Asn 
65                  70                  75                  80  

Asn Val Asp Asn Gln Pro Ala Thr Glu Val Pro Ser Ser Gly Ile Thr 
                85                  90                  95      

Val Lys Leu Asn Ala Lys Asp Asn Ala Gly Asn Trp Thr Ser Ala Ser 

            100                 105                 110         

Asn Lys Lys Glu Val Thr Val Lys Ile Val Ser Ala Lys Pro Thr Tyr 
        115                 120                 125             

Pro Asp Lys Ile Leu Val Lys Asn Pro Asp Asn Ile Lys Asp Thr Glu 
    130                 135                 140                 

Lys Met Pro Leu Leu Lys Asn 
145                 150     

<210>   1079
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1079
ttgaaagagg caaataaaaa tcatccagca ggagctccaa cctttgctaa aggtgaagga   60
gagcatgcaa atgatattgt agcaacttat tcagatggta caacttatta tgtaccgtta   120
aatgatgtga caaaatatgc gagg                                          144

<210>   1080
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1080
Met Lys Glu Ala Asn Lys Asn His Pro Ala Gly Ala Pro Thr Phe Ala 
1               5                   10                  15      

Lys Gly Glu Gly Glu His Ala Asn Asp Ile Val Ala Thr Tyr Ser Asp 
            20                  25                  30          

Gly Thr Thr Tyr Tyr Val Pro Leu Asn Asp Val Thr Lys Tyr Ala Arg 
        35                  40                  45              


<210>   1081
<211>   168
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   1081
atgaaaagta tagtcactag catagatgag cgcttgcgta ctcgcctacg agtgattatc   60
tggaagcaat ggaagaagaa atcgagacga ttatggggat tgcttaagtt aggggttcct   120
aaatggatag cagataaggt atctggctgg ggcgaccact atcaatta                168

<210>   1082
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   group II intron, maturase, degenerate

<400>   1082
Met Lys Ser Ile Val Thr Ser Ile Asp Glu Arg Leu Arg Thr Arg Leu 
1               5                   10                  15      

Arg Val Ile Ile Trp Lys Gln Trp Lys Lys Lys Ser Arg Arg Leu Trp 
            20                  25                  30          

Gly Leu Leu Lys Leu Gly Val Pro Lys Trp Ile Ala Asp Lys Val Ser 
        35                  40                  45              

Gly Trp Gly Asp His Tyr Gln Leu 
    50                  55      

<210>   1083
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1083
ttgctttcta ctgttttgtt ggacttcatc agagtcaaac aggctgaaat tccggccaat   60
aagaccaata aaatcagaaa taaaataaaa cttctcagtc gctttctgct gaca         114

<210>   1084
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1084
Met Leu Ser Thr Val Leu Leu Asp Phe Ile Arg Val Lys Gln Ala Glu 
1               5                   10                  15      

Ile Pro Ala Asn Lys Thr Asn Lys Ile Arg Asn Lys Ile Lys Leu Leu 
            20                  25                  30          

Ser Arg Phe Leu Leu Thr 
        35              

<210>   1085
<211>   162
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1085
atggaggtga caaatgaatc caatccaaag atcttgggct tatgtcagca gaaagcgact   60
gagaagtttt attttatttc tgattttatt ggtcttattg gccggaattt cagcctgttt   120
gactctgatg aagtccaaca aaacagtaga aagcaatctt ta                      162

<210>   1086
<211>   54
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1086
Met Glu Val Thr Asn Glu Ser Asn Pro Lys Ile Leu Gly Leu Cys Gln 
1               5                   10                  15      

Gln Lys Ala Thr Glu Lys Phe Tyr Phe Ile Ser Asp Phe Ile Gly Leu 
            20                  25                  30          

Ile Gly Arg Asn Phe Ser Leu Phe Asp Ser Asp Glu Val Gln Gln Asn 
        35                  40                  45              

Ser Arg Lys Gln Ser Leu 
    50                  

<210>   1087
<211>   1068
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1087
ttgtcagacc tagcatctgt aagcaagatt aaggggctgg aaaatgtctc tcctgaactt   60
gagacggtcg caaaactaaa agacaaggaa gcagtgactg gcgagcagag cgtggagcgt   120
gatgatttat cagctgcaga caataacttg gttagcttaa cggctcttga ggattcatcc   180
aaggatgtaa cctttaccag ttcggctttc aatctaaaag aagggcgaca ccttcaaaaa   240
ggggattcca agaaaatcct tatccacgaa gaattggcta agaagaacgg tctttcgctt   300
catgacaaga ttggcttgga tgctggtcag tctgaatctg gaaaaggaca aacagtagag   360
tttgagatta tcggcatctt ttctggtaaa aaacaagaga aattcacagg cttgtcttct   420
gacttcagtg aaaatcaagt ctttacagac tatgaaagta gccaaaccct tttgggcaat   480
agtgaagctc aagtcagtgc agcacgcttc tatgtagaaa atcctaagga aatggacgga   540
ctcatgaagc aggtagaaaa cttggccttg gaaaatcaag gctaccaagt cgaaaaggaa   600
aacaaggctt ttgaacaaat caaagactca gttgcaactt tccaaacctt cctgaccatc   660
ttcctttatg ggatgttgat agcaggagct ggagccttaa ttctggtttt gtctctctgg   720
ttgagagaac gggtctatga agtggggatt ttacttgcac ttggaaaagg caagagctcg   780
atcttcctac aattctgttt agaggtagtt ttggtatctc ttggagcttt gcttccagca   840
tttgttgcag gaaacgcaat cacaacttac ctactccaaa ctctactagc aagtggagat   900
caggcaagct tacaagatac actagccaaa gcaagcagtt tatcaactag catcttatct   960
tttgcagaat cctatgtttt tctagttctg cttagttgct tatctgtagc cctttgtttc   1020
ctattcttat ttagaaaatc accgaaagaa attttatcat ctattagt                1068

<210>   1088
<211>   356
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transmembrane protein Vexp1 (vex1)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902568 (0.E+01)

<400>   1088
Met Ser Asp Leu Ala Ser Val Ser Lys Ile Lys Gly Leu Glu Asn Val 
1               5                   10                  15      

Ser Pro Glu Leu Glu Thr Val Ala Lys Leu Lys Asp Lys Glu Ala Val 
            20                  25                  30          

Thr Gly Glu Gln Ser Val Glu Arg Asp Asp Leu Ser Ala Ala Asp Asn 
        35                  40                  45              

Asn Leu Val Ser Leu Thr Ala Leu Glu Asp Ser Ser Lys Asp Val Thr 
    50                  55                  60                  

Phe Thr Ser Ser Ala Phe Asn Leu Lys Glu Gly Arg His Leu Gln Lys 
65                  70                  75                  80  

Gly Asp Ser Lys Lys Ile Leu Ile His Glu Glu Leu Ala Lys Lys Asn 
                85                  90                  95      

Gly Leu Ser Leu His Asp Lys Ile Gly Leu Asp Ala Gly Gln Ser Glu 
            100                 105                 110         

Ser Gly Lys Gly Gln Thr Val Glu Phe Glu Ile Ile Gly Ile Phe Ser 
        115                 120                 125             

Gly Lys Lys Gln Glu Lys Phe Thr Gly Leu Ser Ser Asp Phe Ser Glu 
    130                 135                 140                 

Asn Gln Val Phe Thr Asp Tyr Glu Ser Ser Gln Thr Leu Leu Gly Asn 
145                 150                 155                 160 

Ser Glu Ala Gln Val Ser Ala Ala Arg Phe Tyr Val Glu Asn Pro Lys 
                165                 170                 175     

Glu Met Asp Gly Leu Met Lys Gln Val Glu Asn Leu Ala Leu Glu Asn 
            180                 185                 190         

Gln Gly Tyr Gln Val Glu Lys Glu Asn Lys Ala Phe Glu Gln Ile Lys 
        195                 200                 205             

Asp Ser Val Ala Thr Phe Gln Thr Phe Leu Thr Ile Phe Leu Tyr Gly 
    210                 215                 220                 

Met Leu Ile Ala Gly Ala Gly Ala Leu Ile Leu Val Leu Ser Leu Trp 
225                 230                 235                 240 

Leu Arg Glu Arg Val Tyr Glu Val Gly Ile Leu Leu Ala Leu Gly Lys 
                245                 250                 255     

Gly Lys Ser Ser Ile Phe Leu Gln Phe Cys Leu Glu Val Val Leu Val 
            260                 265                 270         

Ser Leu Gly Ala Leu Leu Pro Ala Phe Val Ala Gly Asn Ala Ile Thr 
        275                 280                 285             

Thr Tyr Leu Leu Gln Thr Leu Leu Ala Ser Gly Asp Gln Ala Ser Leu 
    290                 295                 300                 

Gln Asp Thr Leu Ala Lys Ala Ser Ser Leu Ser Thr Ser Ile Leu Ser 
305                 310                 315                 320 

Phe Ala Glu Ser Tyr Val Phe Leu Val Leu Leu Ser Cys Leu Ser Val 
                325                 330                 335     

Ala Leu Cys Phe Leu Phe Leu Phe Arg Lys Ser Pro Lys Glu Ile Leu 
            340                 345                 350         

Ser Ser Ile Ser 
        355     

<210>   1089
<211>   645
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1089
atgactttat tacaattaca agatgttacc taccgttata agaatactgc tgaagcagtc   60
ctatatcaga tcaattataa ttttgaaccc ggaaaatttt acagtattat tggggagtca   120
ggagcaggaa aatccacact cttgtcccta cttgctggtc tagatagtcc tgttgaaggt   180
tctatccttt ttcaaggaga ggatattcgt aagaagggct attcttacca tcgcatgcac   240
catatttccc tggtctttca aaattataac ttgatagatt atctttctcc gctggaaaat   300
atccgattgg tcaacaaaaa ggcaagcaag aatacacttc ttgagcttgg tttggatgaa   360
agccagatca agcggaatgt tctccagtta tcaggtggtc aacagcaacg tgttgccatt   420
gctcgcagtt tggtctcaga agctccagtt attctagctg atgagccaac aggaaatctg   480
gatcctaaaa ctgctggaga tattgtcgaa ctactcaaat cacttgccca gaaaacaggt   540
aaatgtgtga ttgtcgtaac tcacagtaaa gaagtggcac aagcgtcaga tattacactt   600
gaattaaagg ataagaaact gactgaaacg cgcaatacta gtaaa                   645

<210>   1090
<211>   215
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein Vexp2 (vex2)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902569 (e-117)

<400>   1090
Met Thr Leu Leu Gln Leu Gln Asp Val Thr Tyr Arg Tyr Lys Asn Thr 
1               5                   10                  15      

Ala Glu Ala Val Leu Tyr Gln Ile Asn Tyr Asn Phe Glu Pro Gly Lys 
            20                  25                  30          

Phe Tyr Ser Ile Ile Gly Glu Ser Gly Ala Gly Lys Ser Thr Leu Leu 
        35                  40                  45              

Ser Leu Leu Ala Gly Leu Asp Ser Pro Val Glu Gly Ser Ile Leu Phe 
    50                  55                  60                  

Gln Gly Glu Asp Ile Arg Lys Lys Gly Tyr Ser Tyr His Arg Met His 
65                  70                  75                  80  

His Ile Ser Leu Val Phe Gln Asn Tyr Asn Leu Ile Asp Tyr Leu Ser 
                85                  90                  95      

Pro Leu Glu Asn Ile Arg Leu Val Asn Lys Lys Ala Ser Lys Asn Thr 
            100                 105                 110         

Leu Leu Glu Leu Gly Leu Asp Glu Ser Gln Ile Lys Arg Asn Val Leu 
        115                 120                 125             

Gln Leu Ser Gly Gly Gln Gln Gln Arg Val Ala Ile Ala Arg Ser Leu 
    130                 135                 140                 

Val Ser Glu Ala Pro Val Ile Leu Ala Asp Glu Pro Thr Gly Asn Leu 
145                 150                 155                 160 

Asp Pro Lys Thr Ala Gly Asp Ile Val Glu Leu Leu Lys Ser Leu Ala 
                165                 170                 175     

Gln Lys Thr Gly Lys Cys Val Ile Val Val Thr His Ser Lys Glu Val 
            180                 185                 190         

Ala Gln Ala Ser Asp Ile Thr Leu Glu Leu Lys Asp Lys Lys Leu Thr 
        195                 200                 205             

Glu Thr Arg Asn Thr Ser Lys 
    210                 215 

<210>   1091
<211>   1377
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1091
atgttacaca acgcatttgc ctatgttaca aggaagtttt tcaaatcgat tgtcatcttc   60
ctgattattc tcctcatggc gagcttgagt ttggtcggct tgtcaatcaa gggagctact   120
gccaaggctt ctcaggagac ctttaaaaat atcaccaata gcttctccat gcaaatcaat   180
cgtcgcgtca accaaggaac gcctcgtggt gctgggaata tcaagggtga agacatcaaa   240
aaaatcaccg aaaacaaggc cattgagtct tatgtcaaac gtatcaacgc tatcggagat   300
ttgactggat atgacctgat tgaaacgcca gaaaccaaga agaatctcac tgctgatcgt   360
gccaagcgtt ttggaagtag cttgatgatt acaggtgtca atgactcctc taaagaagac   420
aagtttgtct ctggttctta taaactagtc gaaggagagc acttaaccaa cgacgacaag   480
gataaaatcc tcttgcacaa ggacttggca gccaaacacg gctggaaagt aggggacaag   540
gttaaactgg actctaatat ctacgatgca gataatgaaa aaggagccaa ggaaacagtt   600
gaagtgacaa tcaagggact ctttgatggt cataataagt cagcagtaac ctactcacaa   660
gaactttacg aaaacacagc tattacagac attcacactg ctgcaaaact ttatggatac   720
acagaagaca cagccattta tggggacgca accttctttg taacagcaga caagaacttg   780
gatgatgtta tgaaagagtt gaatggcatc agtggtatca actggaagag ctacacactc   840
gtcaagagct cctctaacta cccagctctt gagcaatcta tctctggtat gtacaagatg   900
gccaacctcc tcttctgggg tagcttgagc ttctcagttc tcctccttgc cctcttgctc   960
agcctttgga tcaacgcccg tcgcaaggaa gtgggaattc tcctctctat cggcctcaag   1020
caggcaagta tcttgggtca attcatcacc gaatctatct tgattgctat ccctgctcta   1080
gtttctgctt acttcctagc taattacact gcccgtgcaa ttggaaacac tgtccttgcc   1140
aatgtgactt caggtgttgc caaacaggct agtaaggcgg ctcaagcctc taaccttggt   1200
ggtggtgcag aagtagatgg ctttagcaag accttgtcga gcctagacat ttccattcag   1260
acatcagact ttatcatcat ttttgtcctt gccttggttc tagtggttct cgttatggcg   1320
cttgcttcaa gcaatctcct tagaaaacaa ccaaaagagc tcttgctgga tggtgaa      1377

<210>   1092
<211>   459
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transmembrane protein Vexp3 (vex3)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902570 (0.E+01)

<400>   1092
Met Leu His Asn Ala Phe Ala Tyr Val Thr Arg Lys Phe Phe Lys Ser 
1               5                   10                  15      

Ile Val Ile Phe Leu Ile Ile Leu Leu Met Ala Ser Leu Ser Leu Val 
            20                  25                  30          

Gly Leu Ser Ile Lys Gly Ala Thr Ala Lys Ala Ser Gln Glu Thr Phe 
        35                  40                  45              

Lys Asn Ile Thr Asn Ser Phe Ser Met Gln Ile Asn Arg Arg Val Asn 
    50                  55                  60                  

Gln Gly Thr Pro Arg Gly Ala Gly Asn Ile Lys Gly Glu Asp Ile Lys 
65                  70                  75                  80  

Lys Ile Thr Glu Asn Lys Ala Ile Glu Ser Tyr Val Lys Arg Ile Asn 
                85                  90                  95      

Ala Ile Gly Asp Leu Thr Gly Tyr Asp Leu Ile Glu Thr Pro Glu Thr 
            100                 105                 110         

Lys Lys Asn Leu Thr Ala Asp Arg Ala Lys Arg Phe Gly Ser Ser Leu 
        115                 120                 125             

Met Ile Thr Gly Val Asn Asp Ser Ser Lys Glu Asp Lys Phe Val Ser 
    130                 135                 140                 

Gly Ser Tyr Lys Leu Val Glu Gly Glu His Leu Thr Asn Asp Asp Lys 
145                 150                 155                 160 

Asp Lys Ile Leu Leu His Lys Asp Leu Ala Ala Lys His Gly Trp Lys 
                165                 170                 175     

Val Gly Asp Lys Val Lys Leu Asp Ser Asn Ile Tyr Asp Ala Asp Asn 
            180                 185                 190         

Glu Lys Gly Ala Lys Glu Thr Val Glu Val Thr Ile Lys Gly Leu Phe 
        195                 200                 205             

Asp Gly His Asn Lys Ser Ala Val Thr Tyr Ser Gln Glu Leu Tyr Glu 
    210                 215                 220                 

Asn Thr Ala Ile Thr Asp Ile His Thr Ala Ala Lys Leu Tyr Gly Tyr 
225                 230                 235                 240 

Thr Glu Asp Thr Ala Ile Tyr Gly Asp Ala Thr Phe Phe Val Thr Ala 
                245                 250                 255     

Asp Lys Asn Leu Asp Asp Val Met Lys Glu Leu Asn Gly Ile Ser Gly 
            260                 265                 270         

Ile Asn Trp Lys Ser Tyr Thr Leu Val Lys Ser Ser Ser Asn Tyr Pro 
        275                 280                 285             

Ala Leu Glu Gln Ser Ile Ser Gly Met Tyr Lys Met Ala Asn Leu Leu 
    290                 295                 300                 

Phe Trp Gly Ser Leu Ser Phe Ser Val Leu Leu Leu Ala Leu Leu Leu 
305                 310                 315                 320 

Ser Leu Trp Ile Asn Ala Arg Arg Lys Glu Val Gly Ile Leu Leu Ser 
                325                 330                 335     

Ile Gly Leu Lys Gln Ala Ser Ile Leu Gly Gln Phe Ile Thr Glu Ser 
            340                 345                 350         

Ile Leu Ile Ala Ile Pro Ala Leu Val Ser Ala Tyr Phe Leu Ala Asn 
        355                 360                 365             

Tyr Thr Ala Arg Ala Ile Gly Asn Thr Val Leu Ala Asn Val Thr Ser 
    370                 375                 380                 

Gly Val Ala Lys Gln Ala Ser Lys Ala Ala Gln Ala Ser Asn Leu Gly 
385                 390                 395                 400 

Gly Gly Ala Glu Val Asp Gly Phe Ser Lys Thr Leu Ser Ser Leu Asp 
                405                 410                 415     

Ile Ser Ile Gln Thr Ser Asp Phe Ile Ile Ile Phe Val Leu Ala Leu 
            420                 425                 430         

Val Leu Val Val Leu Val Met Ala Leu Ala Ser Ser Asn Leu Leu Arg 
        435                 440                 445             

Lys Gln Pro Lys Glu Leu Leu Leu Asp Gly Glu 
    450                 455                 

<210>   1093
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1093
atggaattta tgagaaagga atttcacaac gttttatcta gtggtcagtt gcttgcagac   60
aaaaggccag caagagacta taatagaaaa                                    90

<210>   1094
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pep27 protein (pep27)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902571 (6.E-10)

<400>   1094
Met Glu Phe Met Arg Lys Glu Phe His Asn Val Leu Ser Ser Gly Gln 
1               5                   10                  15      

Leu Leu Ala Asp Lys Arg Pro Ala Arg Asp Tyr Asn Arg Lys 
            20                  25                  30  

<210>   1095
<211>   654
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1095
atgaaaattt taattgtaga agatgaagag atgatccgtg agggggtcag tgattatttg   60
acggattgtg gctatgaaac tattgaggca gcggacggtc aggaagctct ggagcaattt   120
tctagctatg aggtggccct ggttttactg gatatccaga tgcccaagct caacggctta   180
gaagtcctag ctgagattcg taaaaccagt caggttcctg tcttgatgtt gacagctttt   240
caagatgagg aatacaagat gagtgccttt gcctctttgg cagatggcta tctggaaaaa   300
cctttctccc tctccctttt aaaagtgagg gtggacgcga ttttcaagcg ctactacgat   360
acaggacgaa tcttttctta caaggatacc aaggtggact ttgaaagcta cagtgcaagc   420
ctcgcaggtc aagaagtgcc tatcaatgcc aaagagttgg aaattctgga ctatctagtg   480
aaaaatgaag gccgggcctt gactcgatct cagattatcg atgccgtctg gaaagcgaca   540
gatgaggttc cctttgaccg tgttattgat gtttatatca aggaattgcg gaaaaagcta   600
gacttggatt gtatcctcac tgtgcgcaat gttggttata aattggagcg aaaa         654

<210>   1096

<211>   218
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator VncR (vncR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902572 (e-120)

<400>   1096
Met Lys Ile Leu Ile Val Glu Asp Glu Glu Met Ile Arg Glu Gly Val 
1               5                   10                  15      

Ser Asp Tyr Leu Thr Asp Cys Gly Tyr Glu Thr Ile Glu Ala Ala Asp 
            20                  25                  30          

Gly Gln Glu Ala Leu Glu Gln Phe Ser Ser Tyr Glu Val Ala Leu Val 
        35                  40                  45              

Leu Leu Asp Ile Gln Met Pro Lys Leu Asn Gly Leu Glu Val Leu Ala 
    50                  55                  60                  

Glu Ile Arg Lys Thr Ser Gln Val Pro Val Leu Met Leu Thr Ala Phe 
65                  70                  75                  80  

Gln Asp Glu Glu Tyr Lys Met Ser Ala Phe Ala Ser Leu Ala Asp Gly 
                85                  90                  95      

Tyr Leu Glu Lys Pro Phe Ser Leu Ser Leu Leu Lys Val Arg Val Asp 
            100                 105                 110         

Ala Ile Phe Lys Arg Tyr Tyr Asp Thr Gly Arg Ile Phe Ser Tyr Lys 
        115                 120                 125             

Asp Thr Lys Val Asp Phe Glu Ser Tyr Ser Ala Ser Leu Ala Gly Gln 
    130                 135                 140                 

Glu Val Pro Ile Asn Ala Lys Glu Leu Glu Ile Leu Asp Tyr Leu Val 
145                 150                 155                 160 

Lys Asn Glu Gly Arg Ala Leu Thr Arg Ser Gln Ile Ile Asp Ala Val 
                165                 170                 175     

Trp Lys Ala Thr Asp Glu Val Pro Phe Asp Arg Val Ile Asp Val Tyr 
            180                 185                 190         

Ile Lys Glu Leu Arg Lys Lys Leu Asp Leu Asp Cys Ile Leu Thr Val 
        195                 200                 205             

Arg Asn Val Gly Tyr Lys Leu Glu Arg Lys 
    210                 215             

<210>   1097
<211>   1326
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1097
atgaaacgaa caggtttatt tgcaaagata tttatctata ccttctcgat atttagtgtt   60
ctggttatct gccttcattt agctatttat tttctttttc cttcgactta tctgagtcat   120
cgtcaggaaa ccattggtca aaaggcaaca gccattgccc agtccctaga agggaaagat   180
aggcagagta tcgagcaagt gttagacttg tattcccaga ctagtgatat caaggggacc   240
gtcaaaggtg agatgaccga ggacaagtta gaagtcaagg acagtcttcc tctggacaca   300
gaccgccaga caacctctct ctttattgag gagcgcgagg tgaaaacgca agacggtggt   360
actatgattc tccagtttct agcttccatg gatttacaaa aggaagcgga gcaaatcagt   420
ctccagtttc ttccctatac cttgctggcc tcctttctga tttccctttt ggtggcctac   480
atctacgctc ggactattgt tgcaccgatt ttggaaatca agcgggtgac ccgtcggatg   540
atggacctgg attcccaagt gcgattgcgc gtggattcta aggatgagat aggtaatctc   600
aaggaacaaa tcaatagcct ctaccagcat ctcttgactg ttattgcgga cttgcatgaa   660
aagaatgaag ccattctcca gctggagaag atgaaggtcg aattcctacg aggagcttct   720
catgaattga aaacaccgct ggctagtttg aaaatcctaa tcgaaaatat gagagagaat   780
atcggtcgtt ataaggatag agaccagtat ctgggagttg ccttggggat tgtggatgaa   840
ctcaatcacc atgttctgca gatactttcc ctctcttctg tgcaggaatt gcgagatgat   900
agggaaacaa ttgacctcct ccagatgacg caaaatctgg tcaaagatta tgccttgcta   960
gccaaggaaa gagagctcca gatagacaat agtttgaccc atcagcaggc ttatctaaac   1020
ccatcagtta tgaagttgat tctttctaat ctcatcagca atgccattaa gcactctgtt   1080
ccaggtggct tagttcgaat tggagaaaga gaaggagaac tttttatcga aaatagctgt   1140
agctcagagg aacaagaaaa actagcccag tctttttctg acaatgccag tcgcaaggtc   1200
aaggggtctg gtatggggct ctttgtggtt aagagtctat tagaacatga aaaattagct   1260
tatcgtttcg agatggagga gaatagttta accttcttta tagattttcc aaaagtcgtc   1320
caagac                                                              1326

<210>   1098
<211>   442
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase VncS (vncS)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902573 (0.E+01)

<400>   1098
Met Lys Arg Thr Gly Leu Phe Ala Lys Ile Phe Ile Tyr Thr Phe Ser 
1               5                   10                  15      

Ile Phe Ser Val Leu Val Ile Cys Leu His Leu Ala Ile Tyr Phe Leu 
            20                  25                  30          

Phe Pro Ser Thr Tyr Leu Ser His Arg Gln Glu Thr Ile Gly Gln Lys 
        35                  40                  45              

Ala Thr Ala Ile Ala Gln Ser Leu Glu Gly Lys Asp Arg Gln Ser Ile 
    50                  55                  60                  

Glu Gln Val Leu Asp Leu Tyr Ser Gln Thr Ser Asp Ile Lys Gly Thr 
65                  70                  75                  80  

Val Lys Gly Glu Met Thr Glu Asp Lys Leu Glu Val Lys Asp Ser Leu 
                85                  90                  95      

Pro Leu Asp Thr Asp Arg Gln Thr Thr Ser Leu Phe Ile Glu Glu Arg 
            100                 105                 110         

Glu Val Lys Thr Gln Asp Gly Gly Thr Met Ile Leu Gln Phe Leu Ala 
        115                 120                 125             

Ser Met Asp Leu Gln Lys Glu Ala Glu Gln Ile Ser Leu Gln Phe Leu 
    130                 135                 140                 

Pro Tyr Thr Leu Leu Ala Ser Phe Leu Ile Ser Leu Leu Val Ala Tyr 
145                 150                 155                 160 

Ile Tyr Ala Arg Thr Ile Val Ala Pro Ile Leu Glu Ile Lys Arg Val 
                165                 170                 175     

Thr Arg Arg Met Met Asp Leu Asp Ser Gln Val Arg Leu Arg Val Asp 
            180                 185                 190         

Ser Lys Asp Glu Ile Gly Asn Leu Lys Glu Gln Ile Asn Ser Leu Tyr 
        195                 200                 205             

Gln His Leu Leu Thr Val Ile Ala Asp Leu His Glu Lys Asn Glu Ala 
    210                 215                 220                 

Ile Leu Gln Leu Glu Lys Met Lys Val Glu Phe Leu Arg Gly Ala Ser 
225                 230                 235                 240 

His Glu Leu Lys Thr Pro Leu Ala Ser Leu Lys Ile Leu Ile Glu Asn 
                245                 250                 255     

Met Arg Glu Asn Ile Gly Arg Tyr Lys Asp Arg Asp Gln Tyr Leu Gly 
            260                 265                 270         

Val Ala Leu Gly Ile Val Asp Glu Leu Asn His His Val Leu Gln Ile 
        275                 280                 285             

Leu Ser Leu Ser Ser Val Gln Glu Leu Arg Asp Asp Arg Glu Thr Ile 
    290                 295                 300                 

Asp Leu Leu Gln Met Thr Gln Asn Leu Val Lys Asp Tyr Ala Leu Leu 
305                 310                 315                 320 

Ala Lys Glu Arg Glu Leu Gln Ile Asp Asn Ser Leu Thr His Gln Gln 
                325                 330                 335     

Ala Tyr Leu Asn Pro Ser Val Met Lys Leu Ile Leu Ser Asn Leu Ile 
            340                 345                 350         

Ser Asn Ala Ile Lys His Ser Val Pro Gly Gly Leu Val Arg Ile Gly 
        355                 360                 365             

Glu Arg Glu Gly Glu Leu Phe Ile Glu Asn Ser Cys Ser Ser Glu Glu 
    370                 375                 380                 

Gln Glu Lys Leu Ala Gln Ser Phe Ser Asp Asn Ala Ser Arg Lys Val 
385                 390                 395                 400 

Lys Gly Ser Gly Met Gly Leu Phe Val Val Lys Ser Leu Leu Glu His 
                405                 410                 415     

Glu Lys Leu Ala Tyr Arg Phe Glu Met Glu Glu Asn Ser Leu Thr Phe 
            420                 425                 430         

Phe Ile Asp Phe Pro Lys Val Val Gln Asp 
        435                 440         

<210>   1099
<211>   879
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1099
atggcaatcg tttcagcaga aaaatttgtc caagcagccc gtgacaacgg ttatgcagtt   60
ggtggattta acacaaacaa ccttgagtgg actcaagcta tcttgcgcgc agcagaagct   120
aaaaaagctc cagttttgat ccaaacttca atgggtgctg ctaaatacat gggtggttac   180
aaagttgctc gcaacttgat cgctaacctt gttgaatcaa tgggtatcac tgtaccagta   240
gctatccacc ttgaccacgg tcactacgaa gatgcacttg agtgtatcga agttggttat   300
acttcaatca tgtttgacgg ttcacacctt ccagttgaag aaaaccttaa attggctaaa   360
gaagttgttg aaaaagcaca cgctaaaggt atctcagtag aagctgaagt tggtactatc   420
ggtggtgaag aagatggaat catcggtaaa ggtgaattgg ctccaatcga agacgctaaa   480
gcaatggttg aaactggtat cgacttcttg gcagctggta tcggtaacat ccacggtcct   540
tacccagtaa actgggaagg tcttgacctt gaccacttgc aaaaattgac agaagctctt   600
ccaggattcc caatcgtatt gcacggtgga tcaggtattc ctgatgagca aatccaagca   660
gctatcaaac ttggtgttgc caaagttaac gttaacacag aatgccaaat cgcattcgct   720
aacgcaactc gtaaatttgc tcgtgactac gaagcaaacg aagcagaata cgacaagaaa   780
aaactcttcg acccacgtaa attcttggct gacggtgtaa aagctatcca agcatcggtt   840
gaagaacgta tcgacgtatt cggttcagaa ggtaaagca                          879

<210>   1100
<211>   293
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fructose-bisphosphate aldolase (fba)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902574 (e-167)

<400>   1100
Met Ala Ile Val Ser Ala Glu Lys Phe Val Gln Ala Ala Arg Asp Asn 
1               5                   10                  15      

Gly Tyr Ala Val Gly Gly Phe Asn Thr Asn Asn Leu Glu Trp Thr Gln 
            20                  25                  30          

Ala Ile Leu Arg Ala Ala Glu Ala Lys Lys Ala Pro Val Leu Ile Gln 
        35                  40                  45              

Thr Ser Met Gly Ala Ala Lys Tyr Met Gly Gly Tyr Lys Val Ala Arg 
    50                  55                  60                  

Asn Leu Ile Ala Asn Leu Val Glu Ser Met Gly Ile Thr Val Pro Val 
65                  70                  75                  80  

Ala Ile His Leu Asp His Gly His Tyr Glu Asp Ala Leu Glu Cys Ile 
                85                  90                  95      

Glu Val Gly Tyr Thr Ser Ile Met Phe Asp Gly Ser His Leu Pro Val 
            100                 105                 110         

Glu Glu Asn Leu Lys Leu Ala Lys Glu Val Val Glu Lys Ala His Ala 
        115                 120                 125             

Lys Gly Ile Ser Val Glu Ala Glu Val Gly Thr Ile Gly Gly Glu Glu 
    130                 135                 140                 

Asp Gly Ile Ile Gly Lys Gly Glu Leu Ala Pro Ile Glu Asp Ala Lys 
145                 150                 155                 160 

Ala Met Val Glu Thr Gly Ile Asp Phe Leu Ala Ala Gly Ile Gly Asn 
                165                 170                 175     

Ile His Gly Pro Tyr Pro Val Asn Trp Glu Gly Leu Asp Leu Asp His 
            180                 185                 190         

Leu Gln Lys Leu Thr Glu Ala Leu Pro Gly Phe Pro Ile Val Leu His 
        195                 200                 205             

Gly Gly Ser Gly Ile Pro Asp Glu Gln Ile Gln Ala Ala Ile Lys Leu 
    210                 215                 220                 

Gly Val Ala Lys Val Asn Val Asn Thr Glu Cys Gln Ile Ala Phe Ala 
225                 230                 235                 240 

Asn Ala Thr Arg Lys Phe Ala Arg Asp Tyr Glu Ala Asn Glu Ala Glu 
                245                 250                 255     

Tyr Asp Lys Lys Lys Leu Phe Asp Pro Arg Lys Phe Leu Ala Asp Gly 
            260                 265                 270         

Val Lys Ala Ile Gln Ala Ser Val Glu Glu Arg Ile Asp Val Phe Gly 
        275                 280                 285             

Ser Glu Gly Lys Ala 
    290             

<210>   1101
<211>   1200
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1101
atggaatttt ctatgaaatc agtcaaagga ctactcttta tcatagctag ttttatcttg   60
actcttttga cttggatgaa cacttctccc caattcatga ttccaggact agctttaaca   120
agcctatctc tgacttttat cctagccact cgtctcccac tactagaaag ctggtttcac   180
agtttggaga aggtctacac cgtccacaaa ttcacagcct ttctctcaat catcctacta   240
atctttcata actttagtat gggcggtttg tggggctctc gcttagctgc tcagtttggc   300
aatcttgcca tctatatctt tgccagcatc atccttgtcg cctatttagg caaatacatc   360
caatacgaag cttggcgatg gattcaccgc ctggtttacc tagcctatat tttaggactc   420
tttcacatct acatgataat gggcaatcgt ctccttacat ttaatcttct aagttttctt   480
gttggtagct atgccctttt aggcttacta gctggttttt atatcatttt tctatatcaa   540
aagatttcct tcccctatct agggaaaatt acccatctca aacgcttaaa tcacgatact   600
agagaaattc aaatccatct tagcagacct ttcaactatc aatcaggaca atttgccttt   660
ctaaagattt tccaagaagg ctttgaaagt gctccgcatc ccttttctat ctcaggaggt   720
catggtcaaa ctctttactt tactgttaaa acttcaggcg accataccaa gaatatctat   780
gataatcttc aagccggcag caaagtaacc ctagacagag cttacggaca catgatcata   840
gaagaaggac gagaaaatca ggtttggatt gctggaggta ttgggatcac ccccttcatc   900
tcttacatcc gtgaacatcc tattttagat aaacaggttc acttctacta tagcttccgt   960
ggagatgaaa atgcagtcta cctagattta ctccgtaact atgctcagaa aaatcctaat   1020
tttgaactcc atctaatcga cagtacgaaa gacggctatc ttaattttga acaaaaagaa   1080
gtgcccgaac atgcaaccgt ctatatgtgt ggtcctattt ctatgatgaa ggcacttgcc   1140
aaacagatta agaaacaaaa tccaaaaaca gagcttattt acgaaggatt caagttcaaa   1200

<210>   1102
<211>   400
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902575 (0.E+01)

<400>   1102
Met Glu Phe Ser Met Lys Ser Val Lys Gly Leu Leu Phe Ile Ile Ala 
1               5                   10                  15      

Ser Phe Ile Leu Thr Leu Leu Thr Trp Met Asn Thr Ser Pro Gln Phe 
            20                  25                  30          

Met Ile Pro Gly Leu Ala Leu Thr Ser Leu Ser Leu Thr Phe Ile Leu 
        35                  40                  45              

Ala Thr Arg Leu Pro Leu Leu Glu Ser Trp Phe His Ser Leu Glu Lys 
    50                  55                  60                  

Val Tyr Thr Val His Lys Phe Thr Ala Phe Leu Ser Ile Ile Leu Leu 
65                  70                  75                  80  

Ile Phe His Asn Phe Ser Met Gly Gly Leu Trp Gly Ser Arg Leu Ala 
                85                  90                  95      

Ala Gln Phe Gly Asn Leu Ala Ile Tyr Ile Phe Ala Ser Ile Ile Leu 
            100                 105                 110         

Val Ala Tyr Leu Gly Lys Tyr Ile Gln Tyr Glu Ala Trp Arg Trp Ile 
        115                 120                 125             

His Arg Leu Val Tyr Leu Ala Tyr Ile Leu Gly Leu Phe His Ile Tyr 
    130                 135                 140                 

Met Ile Met Gly Asn Arg Leu Leu Thr Phe Asn Leu Leu Ser Phe Leu 
145                 150                 155                 160 

Val Gly Ser Tyr Ala Leu Leu Gly Leu Leu Ala Gly Phe Tyr Ile Ile 
                165                 170                 175     

Phe Leu Tyr Gln Lys Ile Ser Phe Pro Tyr Leu Gly Lys Ile Thr His 
            180                 185                 190         

Leu Lys Arg Leu Asn His Asp Thr Arg Glu Ile Gln Ile His Leu Ser 
        195                 200                 205             

Arg Pro Phe Asn Tyr Gln Ser Gly Gln Phe Ala Phe Leu Lys Ile Phe 
    210                 215                 220                 

Gln Glu Gly Phe Glu Ser Ala Pro His Pro Phe Ser Ile Ser Gly Gly 
225                 230                 235                 240 

His Gly Gln Thr Leu Tyr Phe Thr Val Lys Thr Ser Gly Asp His Thr 
                245                 250                 255     

Lys Asn Ile Tyr Asp Asn Leu Gln Ala Gly Ser Lys Val Thr Leu Asp 
            260                 265                 270         

Arg Ala Tyr Gly His Met Ile Ile Glu Glu Gly Arg Glu Asn Gln Val 
        275                 280                 285             

Trp Ile Ala Gly Gly Ile Gly Ile Thr Pro Phe Ile Ser Tyr Ile Arg 
    290                 295                 300                 

Glu His Pro Ile Leu Asp Lys Gln Val His Phe Tyr Tyr Ser Phe Arg 
305                 310                 315                 320 

Gly Asp Glu Asn Ala Val Tyr Leu Asp Leu Leu Arg Asn Tyr Ala Gln 
                325                 330                 335     

Lys Asn Pro Asn Phe Glu Leu His Leu Ile Asp Ser Thr Lys Asp Gly 
            340                 345                 350         

Tyr Leu Asn Phe Glu Gln Lys Glu Val Pro Glu His Ala Thr Val Tyr 
        355                 360                 365             

Met Cys Gly Pro Ile Ser Met Met Lys Ala Leu Ala Lys Gln Ile Lys 
    370                 375                 380                 

Lys Gln Asn Pro Lys Thr Glu Leu Ile Tyr Glu Gly Phe Lys Phe Lys 
385                 390                 395                 400 


<210>   1103
<211>   657
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1103
atggaatcta ttttagaagt tttaacccca gataacctag tctttatctt taaaggattt   60
ggcttgaccc tctatatttc tctgattgcc atcatcctct ctactatcat cggtacggtg   120
ctagctgtca cgagaaatgg caaaaatcct gtcttacgca ttatttccag tatttatatc   180
gagtttgtgc gcaacgttcc caaccttctc tggattttta ctatcttttt ggtgttcaaa   240
atgaaatcca caccagcagg tattacagcc tttactctct ttacatcagc agccttggct   300
gagattattc gaggcggtct caatgccgta gacaagggac agtacgaagc aggaatgtca   360
caaggcttca cctcagccca aatcctctac tacatcattc tcccacaagc catccgcaaa   420
atgctaccag ccatcatttc tcagtttgtt accgtgatta aggataccag tctcctctac   480
tctgttatcg ccctacaaga actctttgga gccagccaaa ttctcatggg ccgttatttc   540
gaaccagagc aggtcttcag tctttacatc ctgattgccc tcatctactt cagctttaac   600
ctagcaattt ctagcctgtc tcatatgcta gccaaacgtt ggcaacaagc tgcagaa      657

<210>   1104
<211>   219
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902576 (e-117)

<400>   1104
Met Glu Ser Ile Leu Glu Val Leu Thr Pro Asp Asn Leu Val Phe Ile 
1               5                   10                  15      

Phe Lys Gly Phe Gly Leu Thr Leu Tyr Ile Ser Leu Ile Ala Ile Ile 
            20                  25                  30          

Leu Ser Thr Ile Ile Gly Thr Val Leu Ala Val Thr Arg Asn Gly Lys 
        35                  40                  45              

Asn Pro Val Leu Arg Ile Ile Ser Ser Ile Tyr Ile Glu Phe Val Arg 
    50                  55                  60                  

Asn Val Pro Asn Leu Leu Trp Ile Phe Thr Ile Phe Leu Val Phe Lys 
65                  70                  75                  80  

Met Lys Ser Thr Pro Ala Gly Ile Thr Ala Phe Thr Leu Phe Thr Ser 
                85                  90                  95      

Ala Ala Leu Ala Glu Ile Ile Arg Gly Gly Leu Asn Ala Val Asp Lys 
            100                 105                 110         

Gly Gln Tyr Glu Ala Gly Met Ser Gln Gly Phe Thr Ser Ala Gln Ile 
        115                 120                 125             

Leu Tyr Tyr Ile Ile Leu Pro Gln Ala Ile Arg Lys Met Leu Pro Ala 
    130                 135                 140                 

Ile Ile Ser Gln Phe Val Thr Val Ile Lys Asp Thr Ser Leu Leu Tyr 
145                 150                 155                 160 

Ser Val Ile Ala Leu Gln Glu Leu Phe Gly Ala Ser Gln Ile Leu Met 
                165                 170                 175     

Gly Arg Tyr Phe Glu Pro Glu Gln Val Phe Ser Leu Tyr Ile Leu Ile 
            180                 185                 190         

Ala Leu Ile Tyr Phe Ser Phe Asn Leu Ala Ile Ser Ser Leu Ser His 
        195                 200                 205             

Met Leu Ala Lys Arg Trp Gln Gln Ala Ala Glu 
    210                 215                 

<210>   1105
<211>   675
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1105
atgacagatt tatcatcttg gacagcctat tttcaggatt ttggacaatt tttcaatggt   60
ttcctcttca cccttgccct agcggttggt tcctttatcc tcgctatggt tttgggcatc   120
ttctttggtg ccatgtcaac cagtaaacgt ccaattttac gcattttagc tcgcatcttt   180
gttgaatttt accaaaatac tcccctcttg gtgcagtttg ttattgtttt ttatggccta   240
cctcttatca gtgaccatat catcatgatt ccaatttatt ggacagccgt tctctgcgtg   300
ggactctatc acggcgctta tatcgctgag gttattcgtt cagggattca gtctattcct   360
agtggtcaga tggaggccgc cttgtcgcaa ggttttacct atatcagtgc catgcgcttg   420
attatcttgc ctcaggcctt ccgcatcatt ctccctccat tgaccaacca aattgttaac   480
ctcatcaaga acacctctac tgtagctatc atctctggag tagacttgat gtttgtgact   540
aagtcttggt cggctctcaa cggaaactat ataccagcct ttttaggtgc tgctcttctc   600
tactttgctc tatgcttccc tgttgcccag tttggtcgca agatggagca agccaacaaa   660
aaagcctatt cactt                                                    675

<210>   1106
<211>   225
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902577 (e-126)

<400>   1106
Met Thr Asp Leu Ser Ser Trp Thr Ala Tyr Phe Gln Asp Phe Gly Gln 
1               5                   10                  15      

Phe Phe Asn Gly Phe Leu Phe Thr Leu Ala Leu Ala Val Gly Ser Phe 
            20                  25                  30          

Ile Leu Ala Met Val Leu Gly Ile Phe Phe Gly Ala Met Ser Thr Ser 
        35                  40                  45              

Lys Arg Pro Ile Leu Arg Ile Leu Ala Arg Ile Phe Val Glu Phe Tyr 
    50                  55                  60                  

Gln Asn Thr Pro Leu Leu Val Gln Phe Val Ile Val Phe Tyr Gly Leu 
65                  70                  75                  80  

Pro Leu Ile Ser Asp His Ile Ile Met Ile Pro Ile Tyr Trp Thr Ala 
                85                  90                  95      

Val Leu Cys Val Gly Leu Tyr His Gly Ala Tyr Ile Ala Glu Val Ile 
            100                 105                 110         

Arg Ser Gly Ile Gln Ser Ile Pro Ser Gly Gln Met Glu Ala Ala Leu 
        115                 120                 125             

Ser Gln Gly Phe Thr Tyr Ile Ser Ala Met Arg Leu Ile Ile Leu Pro 
    130                 135                 140                 

Gln Ala Phe Arg Ile Ile Leu Pro Pro Leu Thr Asn Gln Ile Val Asn 
145                 150                 155                 160 

Leu Ile Lys Asn Thr Ser Thr Val Ala Ile Ile Ser Gly Val Asp Leu 
                165                 170                 175     

Met Phe Val Thr Lys Ser Trp Ser Ala Leu Asn Gly Asn Tyr Ile Pro 
            180                 185                 190         

Ala Phe Leu Gly Ala Ala Leu Leu Tyr Phe Ala Leu Cys Phe Pro Val 
        195                 200                 205             

Ala Gln Phe Gly Arg Lys Met Glu Gln Ala Asn Lys Lys Ala Tyr Ser 
    210                 215                 220                 

Leu 
225 

<210>   1107
<211>   762
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1107
ttgattagcc ttttcggcct tgctgctgcc aaaccagtcc aggctgatac aagtatcgca   60
gacattcaaa aaagaggcga actggttgtc ggtgtcaaac aagacgttcc caattttggt   120
tacaaagatc ccaagaccgg tacttattct ggtatcgaaa ccgacttggc caagatggta   180
gctgatgaac tcaaggtcaa gattcgctat gtgccggtta cagcacaaac ccgcggcccc   240
cttctagaca atgaacaggt cgatatggat atcgcgacct ttaccatcac ggacgaacgc   300
aaaaaactct acaactttac cagtccctac tacacagacg cttctggatt tttggtcaat   360
aaatctgcca aaatcaaaaa gattgaggac ctaaacggca aaaccatcgg agtcgcccaa   420
ggttctatca cccaacgcct gattactgaa ctgggtaaaa agaaaggtct gaagtttaaa   480
ttcgtcgaac ttggttccta cccagaattg attacttccc tgcacgctca tcgtatcgat   540
accttttccg ttgaccgctc tattctatct ggctacacta gtaaacggac agcactacta   600
gatgatagtt tcaagccatc tgactacggt attgttacca agaaatcaaa tacagagctc   660
aacgactatc ttgataactt ggttactaaa tggagcaagg atggtagttt gcagaaactt   720
tatgaccgtt acaagctcaa accatctagc catactgcag at                      762

<210>   1108
<211>   254
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, amino acid-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902578 (e-143)

<400>   1108
Met Ile Ser Leu Phe Gly Leu Ala Ala Ala Lys Pro Val Gln Ala Asp 
1               5                   10                  15      

Thr Ser Ile Ala Asp Ile Gln Lys Arg Gly Glu Leu Val Val Gly Val 
            20                  25                  30          

Lys Gln Asp Val Pro Asn Phe Gly Tyr Lys Asp Pro Lys Thr Gly Thr 
        35                  40                  45              

Tyr Ser Gly Ile Glu Thr Asp Leu Ala Lys Met Val Ala Asp Glu Leu 
    50                  55                  60                  

Lys Val Lys Ile Arg Tyr Val Pro Val Thr Ala Gln Thr Arg Gly Pro 
65                  70                  75                  80  

Leu Leu Asp Asn Glu Gln Val Asp Met Asp Ile Ala Thr Phe Thr Ile 
                85                  90                  95      

Thr Asp Glu Arg Lys Lys Leu Tyr Asn Phe Thr Ser Pro Tyr Tyr Thr 
            100                 105                 110         

Asp Ala Ser Gly Phe Leu Val Asn Lys Ser Ala Lys Ile Lys Lys Ile 
        115                 120                 125             

Glu Asp Leu Asn Gly Lys Thr Ile Gly Val Ala Gln Gly Ser Ile Thr 
    130                 135                 140                 

Gln Arg Leu Ile Thr Glu Leu Gly Lys Lys Lys Gly Leu Lys Phe Lys 
145                 150                 155                 160 

Phe Val Glu Leu Gly Ser Tyr Pro Glu Leu Ile Thr Ser Leu His Ala 
                165                 170                 175     

His Arg Ile Asp Thr Phe Ser Val Asp Arg Ser Ile Leu Ser Gly Tyr 
            180                 185                 190         

Thr Ser Lys Arg Thr Ala Leu Leu Asp Asp Ser Phe Lys Pro Ser Asp 
        195                 200                 205             

Tyr Gly Ile Val Thr Lys Lys Ser Asn Thr Glu Leu Asn Asp Tyr Leu 
    210                 215                 220                 

Asp Asn Leu Val Thr Lys Trp Ser Lys Asp Gly Ser Leu Gln Lys Leu 
225                 230                 235                 240 

Tyr Asp Arg Tyr Lys Leu Lys Pro Ser Ser His Thr Ala Asp 
                245                 250                 

<210>   1109
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1109
atggctttag tagaatttaa aaacgtcgaa aaatattacg gagactacca cgcattccgc   60
aacatcaatc tccgttttga aaaaggacaa gttgttgtcc tgcttggacc ttctggctct   120
gggaagtcca ctcttatccg tacgatcaat ggtttagaga ctgttgacaa aggaagtctc   180
ctagtcaatg ggcaccaagt tgctggtgcc agccagaaag atttggtacc tcttcgcaag   240
gaagtcggca tggtttttca acattttaac ctttatccac acaaagctgt gttagaaaac   300
gtaacgcttg cacccattga agttctagga attgataaaa aagaagctga aaaaaccgcc   360
caaaaatatc tggaatttgt aaatatgtgg gacaagaaag attcctatcc cgccatgcta   420
tctggtggac aaaaacagcg gatcgccatc gctcgtggtc ttgctatgca tccggaactc   480
ctcctctttg atgaaccaac atctgctctt gatcctgaga ctatcggaga tgttctagca   540
gttatgcaga aactggcgca tgatgggatg aacatgatca tcgttaccca cgaaatgggc   600
tttgctcgag aggttgcgga ccgcattatc tttatggccg acggagaagt tttagtagat   660
acgacagatg tcgataactt ttttgacaat ccaagcgaac ctcgtgccca acaattcctc   720
agcaaaatta tcaaccacga aagtgacaaa gtcaaa                             756

<210>   1110
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902772 (2.E-72)

<400>   1110
Met Ala Leu Val Glu Phe Lys Asn Val Glu Lys Tyr Tyr Gly Asp Tyr 
1               5                   10                  15      

His Ala Phe Arg Asn Ile Asn Leu Arg Phe Glu Lys Gly Gln Val Val 
            20                  25                  30          

Val Leu Leu Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Ile Arg Thr 
        35                  40                  45              

Ile Asn Gly Leu Glu Thr Val Asp Lys Gly Ser Leu Leu Val Asn Gly 
    50                  55                  60                  

His Gln Val Ala Gly Ala Ser Gln Lys Asp Leu Val Pro Leu Arg Lys 
65                  70                  75                  80  

Glu Val Gly Met Val Phe Gln His Phe Asn Leu Tyr Pro His Lys Ala 
                85                  90                  95      

Val Leu Glu Asn Val Thr Leu Ala Pro Ile Glu Val Leu Gly Ile Asp 
            100                 105                 110         

Lys Lys Glu Ala Glu Lys Thr Ala Gln Lys Tyr Leu Glu Phe Val Asn 
        115                 120                 125             

Met Trp Asp Lys Lys Asp Ser Tyr Pro Ala Met Leu Ser Gly Gly Gln 
    130                 135                 140                 

Lys Gln Arg Ile Ala Ile Ala Arg Gly Leu Ala Met His Pro Glu Leu 
145                 150                 155                 160 

Leu Leu Phe Asp Glu Pro Thr Ser Ala Leu Asp Pro Glu Thr Ile Gly 
                165                 170                 175     

Asp Val Leu Ala Val Met Gln Lys Leu Ala His Asp Gly Met Asn Met 
            180                 185                 190         

Ile Ile Val Thr His Glu Met Gly Phe Ala Arg Glu Val Ala Asp Arg 
        195                 200                 205             

Ile Ile Phe Met Ala Asp Gly Glu Val Leu Val Asp Thr Thr Asp Val 
    210                 215                 220                 

Asp Asn Phe Phe Asp Asn Pro Ser Glu Pro Arg Ala Gln Gln Phe Leu 
225                 230                 235                 240 

Ser Lys Ile Ile Asn His Glu Ser Asp Lys Val Lys 
                245                 250         

<210>   1111
<211>   2232
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1111
gtggatgtct ttttgataac acctacttat gaatggcagt ttgccctgca ggtagaagat   60
gcggatttta caaagatagc caagaaggct ggactgggtc ctgaggtggc tcggttattg   120
tttgagagag ggattcagaa ccaagaaagt ctgaagaagt ttttagaacc ttccttggag   180
gacttacatg atgcttatct gctccatgat atggacaagg cagtggagcg gattcgtcag   240
gctattgaag aaggggaaaa tattcttgtt tatggagact atgatgcgga tggcatgact   300
tcggcttcta ttgtgaagga aagtttggaa caacttggtg ctgagtgccg agtttacctg   360
ccaaatcgtt ttaccgatgg ctatggccct aatgctagtg tttataaata ctttatcgag   420
caagaaggga tttccttgat tgtgacggtg gacaatgggg ttgctggtca tgaggctatt   480
gcattggctc agtctatggg agtagatgtc attgtgacag accatcattc catgcctgaa   540
accctgccag atgcttatgc tattgtccat cctgaacatc cagatgcgga ttatcctttt   600
aaatatttgg ctggttgtgg agttgctttc aagttggctt gtgccctgtt agaagaagtg   660
caagtggaat tgcttgattt ggtcgctatt ggaactattg cagatatggt gagtctgacg   720
gatgaaaatc gtatcttagt tcaatatggt ctggaaatgt tgggtcatac ccagcgcatt   780
ggtctgcaag aaatgctgga catggctggg attgctgcca acgaagtaac agaagaaacg   840
gttggtttcc agattgctcc tcgtttgaat gccttgggtc gcttggatga tcccaatcct   900
gccattgatt tgttgactgg atttgatgat gaggaagcgc atgagattgc ccttatgatt   960
caccagaaaa acgaagagcg caaggaaatc gttcagtcta tctatgaaga agccaagacc   1020
atggtggatc ctgagaagaa ggttcaggtc ttggccaagg aaggctggaa tcctggggtt   1080
ctaggaatcg tggctggtcg tttattggaa gaattgggac agacagtcat tgttcttaat   1140
atagaagacg gtcgtgccaa gggcagtgct cgtagtgtgg aagcggtcga tatttttgaa   1200
gctctggatc cccatcgaga cctcttcatc gcctttggag gtcatgcagg tgcagcgggt   1260
atgacgctgg aagttgagca actctcagat ttatctcagg ttttggaaga ttatgttcgt   1320
gaaaaaggtg cagatgctgg tggcaagaat aagttaaacc tagatgaaga gttggatttg   1380
gaggcactta gcttggaaac ggtcaaaagt tttgaacgtt tagctccttt tggaatggat   1440
aatcagaaac ctatttttta tatcaagaat tttcaggtcg aaagtgctcg tactatgggg   1500
gcaggtaatg cccatctaaa gctgaaaatt tccaagggtg aggcgagttt tgaagtggta   1560
gcctttggtc aaggcagatg ggcgacagag ttttctcaaa ccaagaatct agagttagcg   1620
gttaaattgt ctgtcaacca atggaatggc caaactgccc tccagttgat gatggtggat   1680
gcgcgagtgg aaggtgttca actttttaac attcgtggaa aaaatgcagt cttgccagaa   1740
ggtgttccag tcttggattt tcctggagaa ctgccaaatc ttgcggctag tgaagctgtt   1800
gtcgtaaaaa acattccaga ggatattact cagctgaaga ccatttttca ggaacagcat   1860
ttctctgctg tctatttcaa aaatgatatt gacaaggctt attatctgac aggttatggg   1920
actagagatc agtttgccaa attgtacaag actatttacc agttcccaga gtttgatatt   1980
cgctacaagc tgaaagattt ggctgcatat cttaatattc aacaaatctt gctggtcaag   2040
atgattcaag tatttgaaga actaggcttt gtgacgataa aagatggtgt gatgacagtc   2100
aataaagagg cgccaaagcg ggagatagga gaaagtcaaa tttaccaaaa tctcaaacaa   2160
accgttaaag accaagaaat gatggcgctg ggtacggtgc aagaaattta tgattttttg   2220
atggaaaaag ag                                                       2232

<210>   1112
<211>   744
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   single-stranded-DNA-specific exonuclease RecJ (recJ)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902581 (0.E+01)

<400>   1112
Met Asp Val Phe Leu Ile Thr Pro Thr Tyr Glu Trp Gln Phe Ala Leu 
1               5                   10                  15      

Gln Val Glu Asp Ala Asp Phe Thr Lys Ile Ala Lys Lys Ala Gly Leu 
            20                  25                  30          

Gly Pro Glu Val Ala Arg Leu Leu Phe Glu Arg Gly Ile Gln Asn Gln 
        35                  40                  45              

Glu Ser Leu Lys Lys Phe Leu Glu Pro Ser Leu Glu Asp Leu His Asp 
    50                  55                  60                  

Ala Tyr Leu Leu His Asp Met Asp Lys Ala Val Glu Arg Ile Arg Gln 
65                  70                  75                  80  

Ala Ile Glu Glu Gly Glu Asn Ile Leu Val Tyr Gly Asp Tyr Asp Ala 
                85                  90                  95      

Asp Gly Met Thr Ser Ala Ser Ile Val Lys Glu Ser Leu Glu Gln Leu 
            100                 105                 110         

Gly Ala Glu Cys Arg Val Tyr Leu Pro Asn Arg Phe Thr Asp Gly Tyr 
        115                 120                 125             

Gly Pro Asn Ala Ser Val Tyr Lys Tyr Phe Ile Glu Gln Glu Gly Ile 
    130                 135                 140                 

Ser Leu Ile Val Thr Val Asp Asn Gly Val Ala Gly His Glu Ala Ile 
145                 150                 155                 160 

Ala Leu Ala Gln Ser Met Gly Val Asp Val Ile Val Thr Asp His His 
                165                 170                 175     

Ser Met Pro Glu Thr Leu Pro Asp Ala Tyr Ala Ile Val His Pro Glu 
            180                 185                 190         

His Pro Asp Ala Asp Tyr Pro Phe Lys Tyr Leu Ala Gly Cys Gly Val 
        195                 200                 205             

Ala Phe Lys Leu Ala Cys Ala Leu Leu Glu Glu Val Gln Val Glu Leu 
    210                 215                 220                 

Leu Asp Leu Val Ala Ile Gly Thr Ile Ala Asp Met Val Ser Leu Thr 
225                 230                 235                 240 

Asp Glu Asn Arg Ile Leu Val Gln Tyr Gly Leu Glu Met Leu Gly His 
                245                 250                 255     

Thr Gln Arg Ile Gly Leu Gln Glu Met Leu Asp Met Ala Gly Ile Ala 
            260                 265                 270         

Ala Asn Glu Val Thr Glu Glu Thr Val Gly Phe Gln Ile Ala Pro Arg 
        275                 280                 285             

Leu Asn Ala Leu Gly Arg Leu Asp Asp Pro Asn Pro Ala Ile Asp Leu 
    290                 295                 300                 

Leu Thr Gly Phe Asp Asp Glu Glu Ala His Glu Ile Ala Leu Met Ile 
305                 310                 315                 320 

His Gln Lys Asn Glu Glu Arg Lys Glu Ile Val Gln Ser Ile Tyr Glu 
                325                 330                 335     


Glu Ala Lys Thr Met Val Asp Pro Glu Lys Lys Val Gln Val Leu Ala 
            340                 345                 350         

Lys Glu Gly Trp Asn Pro Gly Val Leu Gly Ile Val Ala Gly Arg Leu 
        355                 360                 365             

Leu Glu Glu Leu Gly Gln Thr Val Ile Val Leu Asn Ile Glu Asp Gly 
    370                 375                 380                 

Arg Ala Lys Gly Ser Ala Arg Ser Val Glu Ala Val Asp Ile Phe Glu 
385                 390                 395                 400 

Ala Leu Asp Pro His Arg Asp Leu Phe Ile Ala Phe Gly Gly His Ala 
                405                 410                 415     

Gly Ala Ala Gly Met Thr Leu Glu Val Glu Gln Leu Ser Asp Leu Ser 
            420                 425                 430         

Gln Val Leu Glu Asp Tyr Val Arg Glu Lys Gly Ala Asp Ala Gly Gly 
        435                 440                 445             

Lys Asn Lys Leu Asn Leu Asp Glu Glu Leu Asp Leu Glu Ala Leu Ser 
    450                 455                 460                 

Leu Glu Thr Val Lys Ser Phe Glu Arg Leu Ala Pro Phe Gly Met Asp 
465                 470                 475                 480 

Asn Gln Lys Pro Ile Phe Tyr Ile Lys Asn Phe Gln Val Glu Ser Ala 
                485                 490                 495     

Arg Thr Met Gly Ala Gly Asn Ala His Leu Lys Leu Lys Ile Ser Lys 
            500                 505                 510         

Gly Glu Ala Ser Phe Glu Val Val Ala Phe Gly Gln Gly Arg Trp Ala 
        515                 520                 525             

Thr Glu Phe Ser Gln Thr Lys Asn Leu Glu Leu Ala Val Lys Leu Ser 
    530                 535                 540                 

Val Asn Gln Trp Asn Gly Gln Thr Ala Leu Gln Leu Met Met Val Asp 
545                 550                 555                 560 

Ala Arg Val Glu Gly Val Gln Leu Phe Asn Ile Arg Gly Lys Asn Ala 
                565                 570                 575     

Val Leu Pro Glu Gly Val Pro Val Leu Asp Phe Pro Gly Glu Leu Pro 
            580                 585                 590         

Asn Leu Ala Ala Ser Glu Ala Val Val Val Lys Asn Ile Pro Glu Asp 
        595                 600                 605             

Ile Thr Gln Leu Lys Thr Ile Phe Gln Glu Gln His Phe Ser Ala Val 
    610                 615                 620                 

Tyr Phe Lys Asn Asp Ile Asp Lys Ala Tyr Tyr Leu Thr Gly Tyr Gly 
625                 630                 635                 640 

Thr Arg Asp Gln Phe Ala Lys Leu Tyr Lys Thr Ile Tyr Gln Phe Pro 
                645                 650                 655     

Glu Phe Asp Ile Arg Tyr Lys Leu Lys Asp Leu Ala Ala Tyr Leu Asn 
            660                 665                 670         

Ile Gln Gln Ile Leu Leu Val Lys Met Ile Gln Val Phe Glu Glu Leu 
        675                 680                 685             

Gly Phe Val Thr Ile Lys Asp Gly Val Met Thr Val Asn Lys Glu Ala 
    690                 695                 700                 

Pro Lys Arg Glu Ile Gly Glu Ser Gln Ile Tyr Gln Asn Leu Lys Gln 
705                 710                 715                 720 

Thr Val Lys Asp Gln Glu Met Met Ala Leu Gly Thr Val Gln Glu Ile 
                725                 730                 735     

Tyr Asp Phe Leu Met Glu Lys Glu 
            740                 

<210>   1113
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1113
ttgaaaacag accttcattt tgaaaatcat caaaaaaatg gtataatggt aggaaaagat   60
tcggctgaaa gtatcagaac ttttagaata agaggg                             96

<210>   1114
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1114
Met Lys Thr Asp Leu His Phe Glu Asn His Gln Lys Asn Gly Ile Met 
1               5                   10                  15      

Val Gly Lys Asp Ser Ala Glu Ser Ile Arg Thr Phe Arg Ile Arg Gly 
            20                  25                  30          


<210>   1115
<211>   1659
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1115
atgagtaata tcagtttaac aacacttggt ggtgtgcgtg agaatggaaa aaatatgtac   60
attgctgaaa ttggagagtc catttttgtt ttgaatgtag ggttaaaata tcctgaaaat   120
gaacaattag gggtcgatgt ggtgattcca aacatggatt acctttttga aaatagcgac   180
cgtattgctg gggttttctt gacccacggg catgcggatg ccattggtgc tctaccgtat   240
ctcttggcag aggctaaagt tcctgtattt gggtctgagt tgaccattga gttggcaaag   300
ctctttgtca aaggaaatga tgccgttaag aaatttaatg atttccatgt cattgatgag   360
aatacggaga ttgattttgg tgggacagtg gtttccttct tccctacgac ttactccgtt   420
ccagagagtc tgggaattgt cttgaagaca tcggaaggaa gcatcgttta tacaggtgac   480
ttcaaatttg accaaacggc tagtgaatct tatgcaactg attttgctcg tttggcagag   540
attggtcgtg acggcgtcct ggctctcctc agtgattcgg ccaatgcaga cagcaatatt   600
caggtggcta gtgaaagtga agttagggat gaaattaccc aaactattgc tgactgggaa   660
ggtcgtatca tcgttgcagc tgtttccagt aatctttctc gtattcagca gatttttgac   720
gctgcggata aaacaggtcg acgtatcgtc ttgacaggat ttgatattga aaatatcgtc   780
cgcacagcga ttcgtcttaa gaagttgtct ttagccaacg aaattctttt gattaagcct   840
aaagatatgt ctcgctttga agaccatgag ttgattattc ttgagacagg tcgtatgggt   900
gagcctatca atggacttcg taagatgtcg attggtcgcc atcgttatgt agaaatcaag   960
gatggggacc tagtctatat tgctacggct ccgtctattg ctaaagaagc ctttgttgcg   1020
cgtgtggaaa atatgattta tcaggcaggt ggggttgtca aattgattac ccaaagttta   1080
catgtatcag ggcacggaaa tgtgcgtgat ttgcagctga tgatcaatct tttgcaacct   1140
aagtacctct tccctgtcca aggggagtat cgtgagttgg atgctcacgc taaggctgcc   1200
atggcagttg ggatgttgcc agaacgcatc ttcattccta aaaaggggac gaccatggct   1260
tacgagaatg gagactttgt tccagctgga tcggtttcag caggagatat cttgattgat   1320
gggaatgcca ttggtgatgt tggaaatgtt gttcttcgtg accgtaaggt cttgtcagag   1380
gatggaattt tcatcgtggc tattacagtc aaccgtcgtg agaagaaaat tgtggctagg   1440
gctcgtgttc acacgcgtgg atttgtttat ctcaagaaga gtcgcgatat tctccgtgaa   1500
agttcagaat tgattaacca aacggtagaa gagtatcttc aaggagatga ctttgactgg   1560
gcagatctca aaggtaaggt tcgtgacaat ctgaccaagt acctctttga tcaaaccaag   1620
cgtcgcccag ccattttacc agtagtcatg gaagcaaaa                          1659

<210>   1116
<211>   553
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   metallo-beta-lactamase superfamily protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902582 (0.E+01)

<400>   1116
Met Ser Asn Ile Ser Leu Thr Thr Leu Gly Gly Val Arg Glu Asn Gly 
1               5                   10                  15      

Lys Asn Met Tyr Ile Ala Glu Ile Gly Glu Ser Ile Phe Val Leu Asn 
            20                  25                  30          

Val Gly Leu Lys Tyr Pro Glu Asn Glu Gln Leu Gly Val Asp Val Val 
        35                  40                  45              

Ile Pro Asn Met Asp Tyr Leu Phe Glu Asn Ser Asp Arg Ile Ala Gly 
    50                  55                  60                  

Val Phe Leu Thr His Gly His Ala Asp Ala Ile Gly Ala Leu Pro Tyr 
65                  70                  75                  80  

Leu Leu Ala Glu Ala Lys Val Pro Val Phe Gly Ser Glu Leu Thr Ile 
                85                  90                  95      

Glu Leu Ala Lys Leu Phe Val Lys Gly Asn Asp Ala Val Lys Lys Phe 
            100                 105                 110         

Asn Asp Phe His Val Ile Asp Glu Asn Thr Glu Ile Asp Phe Gly Gly 
        115                 120                 125             


Thr Val Val Ser Phe Phe Pro Thr Thr Tyr Ser Val Pro Glu Ser Leu 
    130                 135                 140                 

Gly Ile Val Leu Lys Thr Ser Glu Gly Ser Ile Val Tyr Thr Gly Asp 
145                 150                 155                 160 

Phe Lys Phe Asp Gln Thr Ala Ser Glu Ser Tyr Ala Thr Asp Phe Ala 
                165                 170                 175     

Arg Leu Ala Glu Ile Gly Arg Asp Gly Val Leu Ala Leu Leu Ser Asp 
            180                 185                 190         

Ser Ala Asn Ala Asp Ser Asn Ile Gln Val Ala Ser Glu Ser Glu Val 
        195                 200                 205             

Arg Asp Glu Ile Thr Gln Thr Ile Ala Asp Trp Glu Gly Arg Ile Ile 
    210                 215                 220                 

Val Ala Ala Val Ser Ser Asn Leu Ser Arg Ile Gln Gln Ile Phe Asp 
225                 230                 235                 240 

Ala Ala Asp Lys Thr Gly Arg Arg Ile Val Leu Thr Gly Phe Asp Ile 
                245                 250                 255     

Glu Asn Ile Val Arg Thr Ala Ile Arg Leu Lys Lys Leu Ser Leu Ala 
            260                 265                 270         

Asn Glu Ile Leu Leu Ile Lys Pro Lys Asp Met Ser Arg Phe Glu Asp 
        275                 280                 285             

His Glu Leu Ile Ile Leu Glu Thr Gly Arg Met Gly Glu Pro Ile Asn 
    290                 295                 300                 

Gly Leu Arg Lys Met Ser Ile Gly Arg His Arg Tyr Val Glu Ile Lys 
305                 310                 315                 320 

Asp Gly Asp Leu Val Tyr Ile Ala Thr Ala Pro Ser Ile Ala Lys Glu 
                325                 330                 335     

Ala Phe Val Ala Arg Val Glu Asn Met Ile Tyr Gln Ala Gly Gly Val 
            340                 345                 350         

Val Lys Leu Ile Thr Gln Ser Leu His Val Ser Gly His Gly Asn Val 
        355                 360                 365             

Arg Asp Leu Gln Leu Met Ile Asn Leu Leu Gln Pro Lys Tyr Leu Phe 
    370                 375                 380                 

Pro Val Gln Gly Glu Tyr Arg Glu Leu Asp Ala His Ala Lys Ala Ala 
385                 390                 395                 400 

Met Ala Val Gly Met Leu Pro Glu Arg Ile Phe Ile Pro Lys Lys Gly 
                405                 410                 415     

Thr Thr Met Ala Tyr Glu Asn Gly Asp Phe Val Pro Ala Gly Ser Val 
            420                 425                 430         

Ser Ala Gly Asp Ile Leu Ile Asp Gly Asn Ala Ile Gly Asp Val Gly 
        435                 440                 445             

Asn Val Val Leu Arg Asp Arg Lys Val Leu Ser Glu Asp Gly Ile Phe 
    450                 455                 460                 

Ile Val Ala Ile Thr Val Asn Arg Arg Glu Lys Lys Ile Val Ala Arg 
465                 470                 475                 480 

Ala Arg Val His Thr Arg Gly Phe Val Tyr Leu Lys Lys Ser Arg Asp 
                485                 490                 495     

Ile Leu Arg Glu Ser Ser Glu Leu Ile Asn Gln Thr Val Glu Glu Tyr 
            500                 505                 510         

Leu Gln Gly Asp Asp Phe Asp Trp Ala Asp Leu Lys Gly Lys Val Arg 
        515                 520                 525             

Asp Asn Leu Thr Lys Tyr Leu Phe Asp Gln Thr Lys Arg Arg Pro Ala 
    530                 535                 540                 

Ile Leu Pro Val Val Met Glu Ala Lys 
545                 550             

<210>   1117
<211>   777
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1117
atggcagtga tgaaaatcga gtattactca caagtattgg atatggagtg gggggtgaat   60
gtcctctacc ctgatgccaa tcgagtggaa gaaccagagt gtgaagatat tcccgtcttg   120
taccttttgc acgggatgtc tggaaatcat aatagttggc ttaagcggac caatgtagaa   180
cgcttgcttc gaggaactaa tctcatcgtt gttatgccca ataccagcaa tggttggtac   240
accgataccc agtatggttt tgactactac acggctctag cagaggaatt gccacaggtt   300
ctgaaacgct tcttccctaa tatgacgagc aagcgtgaaa agacctttat cgctggtctt   360
tctatgggag gctacggctg cttcaaactg gctcttacga caaatcgttt ttctcatgca   420
gctagttttt caggtgccct cagctttcaa aacttttctc ctgaaagtca aaatctggga   480
agtccagcct actggagagg tgtttttgga gagattagag actggacaac tagtccctat   540
tctcttgaaa gtctggctaa aaaatcggat aaaaagacca aactttgggc gtggtgtggc   600
gaacaggatt tcttgtacga agccaataat ctcgcagtga aaaatctcaa aaaactaggt   660
tttgatgtga cctatagcca tagcgctgga actcacgagt ggtactactg ggaaaaacaa   720
ttggaagttt ttttaacaac cctaccaatt gatttcaaat tagaagagag actgact      777

<210>   1118
<211>   259
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tributyrin esterase (estA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902583 (e-156)

<400>   1118
Met Ala Val Met Lys Ile Glu Tyr Tyr Ser Gln Val Leu Asp Met Glu 
1               5                   10                  15      

Trp Gly Val Asn Val Leu Tyr Pro Asp Ala Asn Arg Val Glu Glu Pro 
            20                  25                  30          

Glu Cys Glu Asp Ile Pro Val Leu Tyr Leu Leu His Gly Met Ser Gly 
        35                  40                  45              

Asn His Asn Ser Trp Leu Lys Arg Thr Asn Val Glu Arg Leu Leu Arg 
    50                  55                  60                  

Gly Thr Asn Leu Ile Val Val Met Pro Asn Thr Ser Asn Gly Trp Tyr 
65                  70                  75                  80  

Thr Asp Thr Gln Tyr Gly Phe Asp Tyr Tyr Thr Ala Leu Ala Glu Glu 
                85                  90                  95      

Leu Pro Gln Val Leu Lys Arg Phe Phe Pro Asn Met Thr Ser Lys Arg 
            100                 105                 110         

Glu Lys Thr Phe Ile Ala Gly Leu Ser Met Gly Gly Tyr Gly Cys Phe 
        115                 120                 125             

Lys Leu Ala Leu Thr Thr Asn Arg Phe Ser His Ala Ala Ser Phe Ser 
    130                 135                 140                 

Gly Ala Leu Ser Phe Gln Asn Phe Ser Pro Glu Ser Gln Asn Leu Gly 
145                 150                 155                 160 

Ser Pro Ala Tyr Trp Arg Gly Val Phe Gly Glu Ile Arg Asp Trp Thr 
                165                 170                 175     

Thr Ser Pro Tyr Ser Leu Glu Ser Leu Ala Lys Lys Ser Asp Lys Lys 
            180                 185                 190         

Thr Lys Leu Trp Ala Trp Cys Gly Glu Gln Asp Phe Leu Tyr Glu Ala 
        195                 200                 205             

Asn Asn Leu Ala Val Lys Asn Leu Lys Lys Leu Gly Phe Asp Val Thr 
    210                 215                 220                 

Tyr Ser His Ser Ala Gly Thr His Glu Trp Tyr Tyr Trp Glu Lys Gln 
225                 230                 235                 240 

Leu Glu Val Phe Leu Thr Thr Leu Pro Ile Asp Phe Lys Leu Glu Glu 
                245                 250                 255     

Arg Leu Thr 
            

<210>   1119
<211>   1218
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1119
atgtaccgtt atcaaattgg cattcccaca ttagaatatg atcagtttgt caaagaacat   60
gaattagcca atgtattaca aagtagtgct tgggaggaag ttaagtctaa ttggcaacat   120
gagaagtttg gtgtttacag ggaagaaaaa ttactggcga cagctagtat tttgattaga   180
actcttccgc taggctataa aatgttttac atcccaagag gacctatatt ggattatggg   240
gataaagaac tcttgaattt tgccattcag tctattaagt cctatgctcg cagtaagaga   300
gcggtttttg tgacttttga cccaagtatt tgcctatctc aaagtttaat caatcaggaa   360
aagacagaat ttcctgaaaa tctggctatt attgatagtt tgcaacaaat gggagtaagg   420
tggtcaggaa aaacggagga aatgggagac accattcaac ctcgtattca ggcgaaaata   480
tacaaggaaa attttgaaga agataaactt tccaagtcaa caaaacaggc tattcgaaca   540
gcacgaaaca aagggcttga gattcaatat ggtggactgg aactattaga ttcattttcg   600
gagttgatga aaaaaactga gaagcgaaaa gagattcatt tgaggaatga agcctattat   660
aaaaaattgt tagataattt taaggacaag gcctatatca ccttggccac cttggatgtt   720
tctaaacgtt cgcaagagtt agaagaacag ttagcgaaaa atagagcctt ggaagagacc   780
tttactgagt cgactcgaac ttcaaaagta gaagcgcaga agaaggaaaa agaacgtttg   840
ttagaggaat tgaccttctt gcaggaatat atagatgtag gtcaagcgag agttccttta   900
gcggctactt tgagtttgga atttggtact acctctgtca atatatatgc tggtatggat   960
gatgatttta aacgttacaa tgcaccaatt ttaacttggt atgaaacggc tcgctatgcc   1020
tttgaacgag gtatgatctg gcaaaattta ggtggtgttg aaaactctct caatggtgga   1080
ctttatcatt ttaaggaaaa atttaatcca acgattgaag aatacttggg tgaatttaca   1140
atgcccactc atcctctcta tcctctgtta agacttgctc ttgatttccg taaaacatta   1200
agaaaaaaac atagaaag                                                 1218

<210>   1120
<211>   406
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   beta-lactam resistance factor (fibA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902584 (0.E+01)

<400>   1120
Met Tyr Arg Tyr Gln Ile Gly Ile Pro Thr Leu Glu Tyr Asp Gln Phe 
1               5                   10                  15      

Val Lys Glu His Glu Leu Ala Asn Val Leu Gln Ser Ser Ala Trp Glu 
            20                  25                  30          

Glu Val Lys Ser Asn Trp Gln His Glu Lys Phe Gly Val Tyr Arg Glu 
        35                  40                  45              

Glu Lys Leu Leu Ala Thr Ala Ser Ile Leu Ile Arg Thr Leu Pro Leu 
    50                  55                  60                  

Gly Tyr Lys Met Phe Tyr Ile Pro Arg Gly Pro Ile Leu Asp Tyr Gly 
65                  70                  75                  80  

Asp Lys Glu Leu Leu Asn Phe Ala Ile Gln Ser Ile Lys Ser Tyr Ala 
                85                  90                  95      

Arg Ser Lys Arg Ala Val Phe Val Thr Phe Asp Pro Ser Ile Cys Leu 
            100                 105                 110         

Ser Gln Ser Leu Ile Asn Gln Glu Lys Thr Glu Phe Pro Glu Asn Leu 
        115                 120                 125             

Ala Ile Ile Asp Ser Leu Gln Gln Met Gly Val Arg Trp Ser Gly Lys 
    130                 135                 140                 

Thr Glu Glu Met Gly Asp Thr Ile Gln Pro Arg Ile Gln Ala Lys Ile 
145                 150                 155                 160 

Tyr Lys Glu Asn Phe Glu Glu Asp Lys Leu Ser Lys Ser Thr Lys Gln 
                165                 170                 175     

Ala Ile Arg Thr Ala Arg Asn Lys Gly Leu Glu Ile Gln Tyr Gly Gly 
            180                 185                 190         

Leu Glu Leu Leu Asp Ser Phe Ser Glu Leu Met Lys Lys Thr Glu Lys 
        195                 200                 205             

Arg Lys Glu Ile His Leu Arg Asn Glu Ala Tyr Tyr Lys Lys Leu Leu 
    210                 215                 220                 

Asp Asn Phe Lys Asp Lys Ala Tyr Ile Thr Leu Ala Thr Leu Asp Val 
225                 230                 235                 240 

Ser Lys Arg Ser Gln Glu Leu Glu Glu Gln Leu Ala Lys Asn Arg Ala 
                245                 250                 255     

Leu Glu Glu Thr Phe Thr Glu Ser Thr Arg Thr Ser Lys Val Glu Ala 
            260                 265                 270         

Gln Lys Lys Glu Lys Glu Arg Leu Leu Glu Glu Leu Thr Phe Leu Gln 
        275                 280                 285             

Glu Tyr Ile Asp Val Gly Gln Ala Arg Val Pro Leu Ala Ala Thr Leu 
    290                 295                 300                 

Ser Leu Glu Phe Gly Thr Thr Ser Val Asn Ile Tyr Ala Gly Met Asp 
305                 310                 315                 320 

Asp Asp Phe Lys Arg Tyr Asn Ala Pro Ile Leu Thr Trp Tyr Glu Thr 
                325                 330                 335     

Ala Arg Tyr Ala Phe Glu Arg Gly Met Ile Trp Gln Asn Leu Gly Gly 
            340                 345                 350         

Val Glu Asn Ser Leu Asn Gly Gly Leu Tyr His Phe Lys Glu Lys Phe 
        355                 360                 365             

Asn Pro Thr Ile Glu Glu Tyr Leu Gly Glu Phe Thr Met Pro Thr His 
    370                 375                 380                 

Pro Leu Tyr Pro Leu Leu Arg Leu Ala Leu Asp Phe Arg Lys Thr Leu 
385                 390                 395                 400 

Arg Lys Lys His Arg Lys 
                405     

<210>   1121
<211>   1230
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1121
atggcactaa caacactcac gaaagaagag tttcagactt attctgatca ggtttcttct   60
cgttccttta tgcaatctgt ccagatgggg gatttgctag aaaaaagagg ggctcgaatt   120
gtttatcttg ctttgaaaca agaaggagaa attcaagttg cagctctggt ttatagcctg   180
cccatgctgg gtggtctgca tatggaactc aattcggggc cgatttatac ccaacaagat   240
gctcttccag ttttttatgc agagttaaaa gaatatgcca agcaaaatgg tgtattagag   300
ttgcttgtaa aaccctatga aacttatcaa acttttgata gccaaggtaa tccaatagat   360
gctgagaaaa aaagtattat tcaagatttg actgatttag gttatcaatt tgatggctta   420
acaacaggtt acccaggtgg agaaccagat tggttatact ataaagattt aactgaatta   480
actgaaaaga gtttgcttaa aagttttagc aaaaagggta aacccttggt gaaaaaggct   540
gaaacctttg gcattcggtt gaaaaagtta aaacgtgaag aactatcgat ttttaagaat   600
ataacaaaag aaacctctga acgtagagaa tatagtgata aaagtttaga atattatgag   660
catttttatg atacttttgg agaacaagcg gagtttctca tagcaagctt aaatttttcg   720

gactatatga gcaaattgca aggtgaacaa agtaaactag aagaaaactt ggacaagttg   780
cgacttgatt tgagtaaaaa tcctcattct gagaaaaaac aaaatcaact gagagaatat   840
tctagtcaat ttgaaacgtt tgaagttcga aaagcagaag cgcgagactt gattgaaaaa   900
tatggagaag aagatattgt tttagctggg agtttatttg tttatatgcc tcaggaaacg   960
acttatctct ttagtggttc ctacactgag tttaataagt tctatgcccc tgcactgctt   1020
caaaaatatg ttatgttgga aagcataaaa cgtggaatac ctaaatacaa cttcctaggc   1080
attcaaggga tttttgatgg aagtgatggt gttttgcgtt ttaaacagaa ttttaatggc   1140
tatattgtac gcaaagcagg tactttccgt taccatccat cgcctttaaa atacaaagct   1200
atccagttac tcaaaaaaat agtaggacgt                                    1230

<210>   1122
<211>   410
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   beta-lactam resistance factor (fibB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902585 (0.E+01)

<400>   1122
Met Ala Leu Thr Thr Leu Thr Lys Glu Glu Phe Gln Thr Tyr Ser Asp 
1               5                   10                  15      

Gln Val Ser Ser Arg Ser Phe Met Gln Ser Val Gln Met Gly Asp Leu 
            20                  25                  30          

Leu Glu Lys Arg Gly Ala Arg Ile Val Tyr Leu Ala Leu Lys Gln Glu 
        35                  40                  45              

Gly Glu Ile Gln Val Ala Ala Leu Val Tyr Ser Leu Pro Met Leu Gly 
    50                  55                  60                  

Gly Leu His Met Glu Leu Asn Ser Gly Pro Ile Tyr Thr Gln Gln Asp 
65                  70                  75                  80  

Ala Leu Pro Val Phe Tyr Ala Glu Leu Lys Glu Tyr Ala Lys Gln Asn 
                85                  90                  95      

Gly Val Leu Glu Leu Leu Val Lys Pro Tyr Glu Thr Tyr Gln Thr Phe 
            100                 105                 110         

Asp Ser Gln Gly Asn Pro Ile Asp Ala Glu Lys Lys Ser Ile Ile Gln 
        115                 120                 125             

Asp Leu Thr Asp Leu Gly Tyr Gln Phe Asp Gly Leu Thr Thr Gly Tyr 
    130                 135                 140                 

Pro Gly Gly Glu Pro Asp Trp Leu Tyr Tyr Lys Asp Leu Thr Glu Leu 
145                 150                 155                 160 

Thr Glu Lys Ser Leu Leu Lys Ser Phe Ser Lys Lys Gly Lys Pro Leu 
                165                 170                 175     

Val Lys Lys Ala Glu Thr Phe Gly Ile Arg Leu Lys Lys Leu Lys Arg 
            180                 185                 190         

Glu Glu Leu Ser Ile Phe Lys Asn Ile Thr Lys Glu Thr Ser Glu Arg 
        195                 200                 205             

Arg Glu Tyr Ser Asp Lys Ser Leu Glu Tyr Tyr Glu His Phe Tyr Asp 
    210                 215                 220                 

Thr Phe Gly Glu Gln Ala Glu Phe Leu Ile Ala Ser Leu Asn Phe Ser 
225                 230                 235                 240 

Asp Tyr Met Ser Lys Leu Gln Gly Glu Gln Ser Lys Leu Glu Glu Asn 
                245                 250                 255     

Leu Asp Lys Leu Arg Leu Asp Leu Ser Lys Asn Pro His Ser Glu Lys 
            260                 265                 270         

Lys Gln Asn Gln Leu Arg Glu Tyr Ser Ser Gln Phe Glu Thr Phe Glu 
        275                 280                 285             

Val Arg Lys Ala Glu Ala Arg Asp Leu Ile Glu Lys Tyr Gly Glu Glu 
    290                 295                 300                 

Asp Ile Val Leu Ala Gly Ser Leu Phe Val Tyr Met Pro Gln Glu Thr 
305                 310                 315                 320 

Thr Tyr Leu Phe Ser Gly Ser Tyr Thr Glu Phe Asn Lys Phe Tyr Ala 
                325                 330                 335     

Pro Ala Leu Leu Gln Lys Tyr Val Met Leu Glu Ser Ile Lys Arg Gly 
            340                 345                 350         

Ile Pro Lys Tyr Asn Phe Leu Gly Ile Gln Gly Ile Phe Asp Gly Ser 
        355                 360                 365             

Asp Gly Val Leu Arg Phe Lys Gln Asn Phe Asn Gly Tyr Ile Val Arg 
    370                 375                 380                 

Lys Ala Gly Thr Phe Arg Tyr His Pro Ser Pro Leu Lys Tyr Lys Ala 
385                 390                 395                 400 

Ile Gln Leu Leu Lys Lys Ile Val Gly Arg 
                405                 410 

<210>   1123
<211>   720
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1123
ttgctagaaa ggtggagaga catgcgctgg ctttttcgtt tgataggggc tttcttttct   60
tttgtgtggc gtttgttttg gcgtctggtt tggatagttg tgctcttatg tgtgcttgct   120
ttcggacttc tctggtatct gaacggagat tttcaaggag cgctaaagca agcagaacgg   180
tcagtaaaaa ttggtcaaca aagtattgac caatgggaga aaacagggca actgcctaag   240
ttaagccaga cagatagtca ccagcattct gaaggaaggt gggcacaggc ctctgctcgt   300
atttacctgg atccgcagat ggattcacgc tttcaagagg cttatttaga agcaatccag   360
aactggaatc aaactggtgc ttttaacttt gaactcgtga ctgagtctag taaggcggat   420
attacggcta cggagatgaa cgacggaggc actcctgtgg caggagaggc ggaaagtcaa   480
actaatctct taacagggca attcttgtcc gtaacggtgc ggttgaatca ttattatttg   540
tccaatccat actatggcta ctcctatgaa cgccttgtcc atacggcaga acatgagtta   600
ggtcatgcga ttggcttgga ccatacagat gagaagtctg tcatgcaacc agcaggttcc   660
ttttatggta tccaggaaga ggatgttgca aacctccgaa aaatatatga gactagtgag   720

<210>   1124
<211>   240
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902586 (e-128)

<400>   1124
Met Leu Glu Arg Trp Arg Asp Met Arg Trp Leu Phe Arg Leu Ile Gly 
1               5                   10                  15      

Ala Phe Phe Ser Phe Val Trp Arg Leu Phe Trp Arg Leu Val Trp Ile 
            20                  25                  30          

Val Val Leu Leu Cys Val Leu Ala Phe Gly Leu Leu Trp Tyr Leu Asn 
        35                  40                  45              

Gly Asp Phe Gln Gly Ala Leu Lys Gln Ala Glu Arg Ser Val Lys Ile 
    50                  55                  60                  

Gly Gln Gln Ser Ile Asp Gln Trp Glu Lys Thr Gly Gln Leu Pro Lys 
65                  70                  75                  80  

Leu Ser Gln Thr Asp Ser His Gln His Ser Glu Gly Arg Trp Ala Gln 
                85                  90                  95      

Ala Ser Ala Arg Ile Tyr Leu Asp Pro Gln Met Asp Ser Arg Phe Gln 
            100                 105                 110         

Glu Ala Tyr Leu Glu Ala Ile Gln Asn Trp Asn Gln Thr Gly Ala Phe 
        115                 120                 125             

Asn Phe Glu Leu Val Thr Glu Ser Ser Lys Ala Asp Ile Thr Ala Thr 
    130                 135                 140                 

Glu Met Asn Asp Gly Gly Thr Pro Val Ala Gly Glu Ala Glu Ser Gln 
145                 150                 155                 160 

Thr Asn Leu Leu Thr Gly Gln Phe Leu Ser Val Thr Val Arg Leu Asn 
                165                 170                 175     

His Tyr Tyr Leu Ser Asn Pro Tyr Tyr Gly Tyr Ser Tyr Glu Arg Leu 
            180                 185                 190         

Val His Thr Ala Glu His Glu Leu Gly His Ala Ile Gly Leu Asp His 
        195                 200                 205             

Thr Asp Glu Lys Ser Val Met Gln Pro Ala Gly Ser Phe Tyr Gly Ile 
    210                 215                 220                 

Gln Glu Glu Asp Val Ala Asn Leu Arg Lys Ile Tyr Glu Thr Ser Glu 
225                 230                 235                 240 


<210>   1125
<211>   1842
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1125
atgaacaact tgattaaatc aaaactagag ctcttgccga ccagccctgg ttgctacatt   60
cataaggata aaaatggcac cattatctat gtaggaaagg ctaaaaatct gcgtaatcga   120
gtacggtcct attttcgtgg aagtcatgat accaagacag aggctctggt gtctgaaatt   180
gtggattttg aatttattgt tacggagtct aatattgagg cacttctcct agaaatcaac   240
ctgatcaagg aaaacaagcc caagtacaat atcatgctca aggatgacaa gtcctatcct   300
ttcatcaaaa tcaccaatga gcgctatcca cgcttgatta tcactcgtca ggtcaaaaag   360
gacggaggtc tttattttgg accctatccc gatgtggggg cagccaatga aatcaagcgg   420
ttgctggatc ggatattccc ttttcgtaag tgtaccaacc cgccctctaa ggtctgtttt   480
tattaccata tcggccagtg tatggcccac accatctgta agaaggatga ggcttatttc   540
aagtctatgg cccaggaggt gtctgatttt ctgaaaggtc aggatgacaa aatcatcgat   600
gatctcaaga gtaaaatggc agtagcagca caaagtatgg agtttgaacg tgcggcggaa   660
taccgtgacc tgattcaggc tattggaacg cttcgaacca agcaacgggt catggcgaaa   720
gatttgcaaa atcgcgatgt ctttggctac tatgtggata agggctggat gtgtgtgcag   780
gttttctttg tccgtcaggg taagctcatc gagcgcgatg tcaatctctt cccctacttc   840
aatgatccag atgaggattt tttgacctat gtaggacaat tctatcaaga aaaatctcat   900
ctagttccca atgaggtact gattccgcag gatattgacg aagaagctgt caaggctttg   960
gtggattcca agattcttaa gcctcaacgt ggagagaaaa aacaactggt caatctagcc   1020
ataaaaaatg ctcgtgttag tctagagcag aagttcaatc tgctagaaaa atctgtcgaa   1080
aagactcaag gagctattga aaatctaggg cgtttgctcc aaatcccgac cccagtacgt   1140
atcgagtcct tcgataactc taatatcatg ggaactagcc ctgtttcggc tatggtggtc   1200
tttgtcaacg gtaaaccgag taagaaggat taccgtaagt acaagataaa aacggttgtt   1260
ggaccagacg actatgccag catgagagag gtcattcgca gacgctatgg tcgagtacag   1320
cgtgaggctt tgactcctcc agatttgatt gtgattgatg gggggcaagg tcaagtcaat   1380
atcgctaagc aggttatcca agaggaactg ggcttggata ttccaattgc tgggctgcaa   1440
aagaatgata agcaccaaac ccatgaattg ctctttggag atccgcttga ggtggtggat   1500
ttgtctcgca attctcagga atttttcctc ctccaacgca tccaagatga ggtgcaccgc   1560
tttgctatca ctttccaccg ccaactgcgc tccaaaaatt ctttctcatc tcaattggat   1620
gggattgacg gtctgggacc taaacgcaag cagaatctta tgaagcattt caagtctttg   1680
accaaaatca aggaagccag tgtggatgag attgtcgaag ttggggtacc tagagtcgtt   1740
gcagaggctg tgcaaagaaa gttgaacccg cagggagaag ccttgcctca agtagcagaa   1800
gaaagagtag attaccaaac ggaaggaaac cacaatgaac ca                      1842

<210>   1126
<211>   614
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   excinuclease ABC, subunit C (uvrC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902587 (0.E+01)

<400>   1126
Met Asn Asn Leu Ile Lys Ser Lys Leu Glu Leu Leu Pro Thr Ser Pro 
1               5                   10                  15      

Gly Cys Tyr Ile His Lys Asp Lys Asn Gly Thr Ile Ile Tyr Val Gly 
            20                  25                  30          

Lys Ala Lys Asn Leu Arg Asn Arg Val Arg Ser Tyr Phe Arg Gly Ser 
        35                  40                  45              

His Asp Thr Lys Thr Glu Ala Leu Val Ser Glu Ile Val Asp Phe Glu 
    50                  55                  60                  

Phe Ile Val Thr Glu Ser Asn Ile Glu Ala Leu Leu Leu Glu Ile Asn 
65                  70                  75                  80  

Leu Ile Lys Glu Asn Lys Pro Lys Tyr Asn Ile Met Leu Lys Asp Asp 
                85                  90                  95      

Lys Ser Tyr Pro Phe Ile Lys Ile Thr Asn Glu Arg Tyr Pro Arg Leu 
            100                 105                 110         

Ile Ile Thr Arg Gln Val Lys Lys Asp Gly Gly Leu Tyr Phe Gly Pro 
        115                 120                 125             

Tyr Pro Asp Val Gly Ala Ala Asn Glu Ile Lys Arg Leu Leu Asp Arg 

    130                 135                 140                 

Ile Phe Pro Phe Arg Lys Cys Thr Asn Pro Pro Ser Lys Val Cys Phe 
145                 150                 155                 160 

Tyr Tyr His Ile Gly Gln Cys Met Ala His Thr Ile Cys Lys Lys Asp 
                165                 170                 175     

Glu Ala Tyr Phe Lys Ser Met Ala Gln Glu Val Ser Asp Phe Leu Lys 
            180                 185                 190         

Gly Gln Asp Asp Lys Ile Ile Asp Asp Leu Lys Ser Lys Met Ala Val 
        195                 200                 205             

Ala Ala Gln Ser Met Glu Phe Glu Arg Ala Ala Glu Tyr Arg Asp Leu 
    210                 215                 220                 

Ile Gln Ala Ile Gly Thr Leu Arg Thr Lys Gln Arg Val Met Ala Lys 
225                 230                 235                 240 

Asp Leu Gln Asn Arg Asp Val Phe Gly Tyr Tyr Val Asp Lys Gly Trp 
                245                 250                 255     

Met Cys Val Gln Val Phe Phe Val Arg Gln Gly Lys Leu Ile Glu Arg 
            260                 265                 270         

Asp Val Asn Leu Phe Pro Tyr Phe Asn Asp Pro Asp Glu Asp Phe Leu 
        275                 280                 285             

Thr Tyr Val Gly Gln Phe Tyr Gln Glu Lys Ser His Leu Val Pro Asn 
    290                 295                 300                 

Glu Val Leu Ile Pro Gln Asp Ile Asp Glu Glu Ala Val Lys Ala Leu 
305                 310                 315                 320 

Val Asp Ser Lys Ile Leu Lys Pro Gln Arg Gly Glu Lys Lys Gln Leu 
                325                 330                 335     

Val Asn Leu Ala Ile Lys Asn Ala Arg Val Ser Leu Glu Gln Lys Phe 
            340                 345                 350         

Asn Leu Leu Glu Lys Ser Val Glu Lys Thr Gln Gly Ala Ile Glu Asn 
        355                 360                 365             

Leu Gly Arg Leu Leu Gln Ile Pro Thr Pro Val Arg Ile Glu Ser Phe 
    370                 375                 380                 

Asp Asn Ser Asn Ile Met Gly Thr Ser Pro Val Ser Ala Met Val Val 
385                 390                 395                 400 

Phe Val Asn Gly Lys Pro Ser Lys Lys Asp Tyr Arg Lys Tyr Lys Ile 
                405                 410                 415     

Lys Thr Val Val Gly Pro Asp Asp Tyr Ala Ser Met Arg Glu Val Ile 
            420                 425                 430         

Arg Arg Arg Tyr Gly Arg Val Gln Arg Glu Ala Leu Thr Pro Pro Asp 
        435                 440                 445             

Leu Ile Val Ile Asp Gly Gly Gln Gly Gln Val Asn Ile Ala Lys Gln 
    450                 455                 460                 

Val Ile Gln Glu Glu Leu Gly Leu Asp Ile Pro Ile Ala Gly Leu Gln 
465                 470                 475                 480 

Lys Asn Asp Lys His Gln Thr His Glu Leu Leu Phe Gly Asp Pro Leu 
                485                 490                 495     

Glu Val Val Asp Leu Ser Arg Asn Ser Gln Glu Phe Phe Leu Leu Gln 
            500                 505                 510         

Arg Ile Gln Asp Glu Val His Arg Phe Ala Ile Thr Phe His Arg Gln 
        515                 520                 525             

Leu Arg Ser Lys Asn Ser Phe Ser Ser Gln Leu Asp Gly Ile Asp Gly 
    530                 535                 540                 

Leu Gly Pro Lys Arg Lys Gln Asn Leu Met Lys His Phe Lys Ser Leu 
545                 550                 555                 560 

Thr Lys Ile Lys Glu Ala Ser Val Asp Glu Ile Val Glu Val Gly Val 
                565                 570                 575     

Pro Arg Val Val Ala Glu Ala Val Gln Arg Lys Leu Asn Pro Gln Gly 
            580                 585                 590         

Glu Ala Leu Pro Gln Val Ala Glu Glu Arg Val Asp Tyr Gln Thr Glu 
        595                 600                 605             

Gly Asn His Asn Glu Pro 
    610                 

<210>   1127
<211>   831
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1127
atgaaccata aaatcgcaat tttatcagat gttcatggca atgcgacggc gctagaagca   60
gtgattgcag atgctaaaaa tcaaggggcc agtgaatatt ggcttctggg agatattttt   120
cttcctggtc caggcgcaaa tgacttagtc gccctgctaa aggaccttcc tatcacagca   180
agtgttcgag gcaattggga tgatcgtgtc cttgaggctt tagatgggca atatggctta   240
gaagacccac aggaagttca gctcttgcgt atgacacagt atttgatgga gcgaatggat   300
cctgcaacga ttgtctggct acgaagcttg cctttgctgg aaaagaaaga aattgacgga   360
ttgcgctttt ctatctctca taatttacct gacaaaaact atggtggtga cttgctagtt   420

gagaatgata cagagaaatt tgaccaactg ctagatgcgg aaacggacgt ggcagtttat   480
ggtcatgttc acaagcagtt gcttcgttat ggaagtcaag ggcaacaaat catcaatcca   540
gggtcgattg gcatgcccta ttttaattgg gaggcgttaa aaaatcaccg ttcccagtat   600
gccgtgatag aagttgaaga tggggaatta ctcaatatcc aatttcgtaa agttgcttat   660
gattacgaag ctgagttaga attggccaag tccaaggggc ttccctttat cgaaatgtat   720
gaagaactgc gtcgtgacga taactatcag gggcacaatc tggaattatt agccagctta   780
atagaaaagc atgggtatgt agaggatgtg aagaattttt ttgatttttt g            831

<210>   1128
<211>   277
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902588 (e-161)

<400>   1128
Met Asn His Lys Ile Ala Ile Leu Ser Asp Val His Gly Asn Ala Thr 
1               5                   10                  15      

Ala Leu Glu Ala Val Ile Ala Asp Ala Lys Asn Gln Gly Ala Ser Glu 
            20                  25                  30          

Tyr Trp Leu Leu Gly Asp Ile Phe Leu Pro Gly Pro Gly Ala Asn Asp 
        35                  40                  45              

Leu Val Ala Leu Leu Lys Asp Leu Pro Ile Thr Ala Ser Val Arg Gly 
    50                  55                  60                  

Asn Trp Asp Asp Arg Val Leu Glu Ala Leu Asp Gly Gln Tyr Gly Leu 
65                  70                  75                  80  

Glu Asp Pro Gln Glu Val Gln Leu Leu Arg Met Thr Gln Tyr Leu Met 
                85                  90                  95      

Glu Arg Met Asp Pro Ala Thr Ile Val Trp Leu Arg Ser Leu Pro Leu 
            100                 105                 110         

Leu Glu Lys Lys Glu Ile Asp Gly Leu Arg Phe Ser Ile Ser His Asn 
        115                 120                 125             

Leu Pro Asp Lys Asn Tyr Gly Gly Asp Leu Leu Val Glu Asn Asp Thr 
    130                 135                 140                 

Glu Lys Phe Asp Gln Leu Leu Asp Ala Glu Thr Asp Val Ala Val Tyr 
145                 150                 155                 160 

Gly His Val His Lys Gln Leu Leu Arg Tyr Gly Ser Gln Gly Gln Gln 
                165                 170                 175     

Ile Ile Asn Pro Gly Ser Ile Gly Met Pro Tyr Phe Asn Trp Glu Ala 
            180                 185                 190         

Leu Lys Asn His Arg Ser Gln Tyr Ala Val Ile Glu Val Glu Asp Gly 
        195                 200                 205             

Glu Leu Leu Asn Ile Gln Phe Arg Lys Val Ala Tyr Asp Tyr Glu Ala 
    210                 215                 220                 

Glu Leu Glu Leu Ala Lys Ser Lys Gly Leu Pro Phe Ile Glu Met Tyr 
225                 230                 235                 240 

Glu Glu Leu Arg Arg Asp Asp Asn Tyr Gln Gly His Asn Leu Glu Leu 
                245                 250                 255     

Leu Ala Ser Leu Ile Glu Lys His Gly Tyr Val Glu Asp Val Lys Asn 
            260                 265                 270         

Phe Phe Asp Phe Leu 
        275         

<210>   1129
<211>   813
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1129
ttgaatggag acagtatgaa aaaatttagc ctattactag ctatcctacc atttttggtt   60
gcctgtgaga atcaagctac acccaaagag actagcgctc aaaagacaat cgtccttgct   120
acagctggcg acgtgccacc atttgactac gaagacaagg gcaatctgac aggctttgat   180
atcgaagttt taaaggcagt agatgaaaaa ctcagcgact acgagattca attccaaaga   240
accgcctggg agagcatctt cccaggactt gattctggtc actatcaggc tgcggccaat   300
aacttgagtt acacaaaaga gcgtgctgaa aaataccttt actcgcttcc aatttccaac   360
aatcccctcg tccttgtcag caacaagaaa aatcctttga cttctcttga ccagatcgct   420
ggtaaaacaa cacaagagga taccggaact tctaacgctc aattcatcaa taactggaat   480
cagaaacaca ctgataatcc cgctacaatt aatttttctg gtgaggatat tggtaaacga   540
atcctagacc ttgctaacgg agagtttgat ttcctagttt ttgacaaggt atccgttcaa   600
aagattatca aggaccgtgg tttagacctc tcagtcgttg atttaccttc tgcagatagc   660
cccagcaatt atatcatttt ctcaagcgac caaaaagagt ttaaagagca atttgataaa   720
gcgctcaaag aactctatca agacggaacc cttgaaaaac tcagcaatac ctatctaggt   780
ggttcttacc tcccagatca atctcagtta caa                                813

<210>   1130
<211>   271
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, amino acid-binding protein, putative
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902589 (e-151)

<400>   1130
Met Asn Gly Asp Ser Met Lys Lys Phe Ser Leu Leu Leu Ala Ile Leu 
1               5                   10                  15      

Pro Phe Leu Val Ala Cys Glu Asn Gln Ala Thr Pro Lys Glu Thr Ser 
            20                  25                  30          

Ala Gln Lys Thr Ile Val Leu Ala Thr Ala Gly Asp Val Pro Pro Phe 
        35                  40                  45              

Asp Tyr Glu Asp Lys Gly Asn Leu Thr Gly Phe Asp Ile Glu Val Leu 
    50                  55                  60                  

Lys Ala Val Asp Glu Lys Leu Ser Asp Tyr Glu Ile Gln Phe Gln Arg 

65                  70                  75                  80  

Thr Ala Trp Glu Ser Ile Phe Pro Gly Leu Asp Ser Gly His Tyr Gln 
                85                  90                  95      

Ala Ala Ala Asn Asn Leu Ser Tyr Thr Lys Glu Arg Ala Glu Lys Tyr 
            100                 105                 110         

Leu Tyr Ser Leu Pro Ile Ser Asn Asn Pro Leu Val Leu Val Ser Asn 
        115                 120                 125             

Lys Lys Asn Pro Leu Thr Ser Leu Asp Gln Ile Ala Gly Lys Thr Thr 
    130                 135                 140                 

Gln Glu Asp Thr Gly Thr Ser Asn Ala Gln Phe Ile Asn Asn Trp Asn 
145                 150                 155                 160 

Gln Lys His Thr Asp Asn Pro Ala Thr Ile Asn Phe Ser Gly Glu Asp 
                165                 170                 175     

Ile Gly Lys Arg Ile Leu Asp Leu Ala Asn Gly Glu Phe Asp Phe Leu 
            180                 185                 190         

Val Phe Asp Lys Val Ser Val Gln Lys Ile Ile Lys Asp Arg Gly Leu 
        195                 200                 205             

Asp Leu Ser Val Val Asp Leu Pro Ser Ala Asp Ser Pro Ser Asn Tyr 
    210                 215                 220                 

Ile Ile Phe Ser Ser Asp Gln Lys Glu Phe Lys Glu Gln Phe Asp Lys 
225                 230                 235                 240 

Ala Leu Lys Glu Leu Tyr Gln Asp Gly Thr Leu Glu Lys Leu Ser Asn 
                245                 250                 255     

Thr Tyr Leu Gly Gly Ser Tyr Leu Pro Asp Gln Ser Gln Leu Gln 
            260                 265                 270     

<210>   1131
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1131
atgtctgtga tagaaaaact taatcatgaa aaatccctgc aagctctttc aaattatggt   60
agaatggaag cagtagaatt agaaaaggaa atcgattatg aaatttct                108

<210>   1132
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1132
Met Ser Val Ile Glu Lys Leu Asn His Glu Lys Ser Leu Gln Ala Leu 
1               5                   10                  15      

Ser Asn Tyr Gly Arg Met Glu Ala Val Glu Leu Glu Lys Glu Ile Asp 
            20                  25                  30          

Tyr Glu Ile Ser 
        35      

<210>   1133
<211>   603
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1133
atgaaatttc ttgaattaaa taaaaaacgt catgcgacta agcattttac tgataagctt   60
gttgatccca aagatgtgcg tacggctatc gaaattgcaa ccttggcgcc aagcgcccac   120
aacagccagc cttggaaatt tgtggtggta cgtgagaaaa atgctgaact ggcaaagtta   180
gcttatggtt ccaattttga acaggtatca tcagcgcctg taaccattgc cttgtttaca   240
gatacggact tagccaaacg tgctcgtaag attgcccgtg ttggtggtgc taataacttt   300
tctgaagagc aacttcaata ttttatgaaa aatctgccag ctgagtttgc ccgttacagt   360
gagcaacaag tcagcgacta cctagctctc aatgcaggtt tggttgccat gaacttggtt   420
cttgcattga cagaccaagg aattggttct aacattattc ttggttttga caaatcaaaa   480
gttaatgaag ttttggaaat cgaagaccgt ttccgcccag aactcttgat cacagtgggt   540
tatacagacg aaaaattgga accaagctac cgcttgccag tagatgaaat catcgagaaa   600
aga                                                                 603

<210>   1134
<211>   201
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   nitroreductase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902590 (e-110)

<400>   1134
Met Lys Phe Leu Glu Leu Asn Lys Lys Arg His Ala Thr Lys His Phe 
1               5                   10                  15      

Thr Asp Lys Leu Val Asp Pro Lys Asp Val Arg Thr Ala Ile Glu Ile 
            20                  25                  30          

Ala Thr Leu Ala Pro Ser Ala His Asn Ser Gln Pro Trp Lys Phe Val 
        35                  40                  45              

Val Val Arg Glu Lys Asn Ala Glu Leu Ala Lys Leu Ala Tyr Gly Ser 
    50                  55                  60                  

Asn Phe Glu Gln Val Ser Ser Ala Pro Val Thr Ile Ala Leu Phe Thr 
65                  70                  75                  80  

Asp Thr Asp Leu Ala Lys Arg Ala Arg Lys Ile Ala Arg Val Gly Gly 
                85                  90                  95      

Ala Asn Asn Phe Ser Glu Glu Gln Leu Gln Tyr Phe Met Lys Asn Leu 
            100                 105                 110         

Pro Ala Glu Phe Ala Arg Tyr Ser Glu Gln Gln Val Ser Asp Tyr Leu 
        115                 120                 125             

Ala Leu Asn Ala Gly Leu Val Ala Met Asn Leu Val Leu Ala Leu Thr 
    130                 135                 140                 

Asp Gln Gly Ile Gly Ser Asn Ile Ile Leu Gly Phe Asp Lys Ser Lys 
145                 150                 155                 160 

Val Asn Glu Val Leu Glu Ile Glu Asp Arg Phe Arg Pro Glu Leu Leu 
                165                 170                 175     

Ile Thr Val Gly Tyr Thr Asp Glu Lys Leu Glu Pro Ser Tyr Arg Leu 
            180                 185                 190         

Pro Val Asp Glu Ile Ile Glu Lys Arg 
        195                 200     

<210>   1135
<211>   1398
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1135
atgacagcaa ttgattttac agcagaagta gaaaaacgca aagaagacct cttggctgac   60
ttgtttagcc ttttggaaat caattcagaa cgtgatgaca gcaaggctga tgcccagcat   120
ccatttgggc ctggtccagt aaaagccttg gagaaattcc ttgaaatcgc agaccgcgat   180
ggctacccaa ctaagaatgt tgataactat gcaggacatt ttgagtttgg tgatggagaa   240
gaagttctcg gaatctttgc ccatatggat gtggtgcctg ctggtagcgg ttgggacaca   300
gacccttaca caccaactat caaagatggt cgcctttatg cgcgcggggc ttcggacgat   360
aagggtccta caacagcttg ttactatggt ttgaaaatca tcaaagaatt gggtcttcca   420
acttctaaga aagttcgctt catcgttgga acagacgaag aatcaggctg ggcagacatg   480
gactactact ttgagcacgt aggacttgcc aaaccagatt tcggtttctc accagatgct   540
gaatttccaa tcatcaatgg tgaaaaagga aatatcacgg aatacctcca ctttgcagga   600
gaaaatacag gtgttgcccg tcttcacagc tttacaggtg gtttacgtga aaatatggta   660
ccagaatcag caacagcagt cgtttcaggt gacttggctg acttgcaagc taaactagat   720
gcctttgttg cagaacacaa acttagagga gaactccaag aagaagctgg caaatacaag   780
gtgacgatca ttggtaaatc agcccacggt gctatgcctg cttcaggtgt caatggcgca   840
acttaccttg ccctcttcct cagccagttt ggctttgctg gtccagccaa agactacctt   900
gacatcgcag gtaaaattct cttgaacgat catgagggtg aaaatcttaa gattgctcat   960
gtggatgaaa agatgggtgc tctttctatg aatgccggcg tcttccactt cgatgaaaca   1020
agtgctgata ataccattgc cctcaacatc cgctatccaa aaggaacaag tccagaacaa   1080
atcaagtcaa tccttgaaaa cttgccagtt gtttctgtta gcctgtctga acacggtcac   1140
acgcctcact atgtgccaat ggaagatcca cttgtgcaaa ccttgttgaa tatctatgaa   1200
aaacaaactg gctttaaagg tcatgaacaa gtcatcggtg gtggaacctt tggtcgcttg   1260
ctagaacgcg gagttgccta cggtgctatg ttcccagact cgattgatac catgcaccaa   1320
gccaatgaat ttatcgcctt ggatgatctt ttccgagcag cagcaattta tgccgaagct   1380
atttacgaat tgatcaaa                                                 1398

<210>   1136
<211>   466
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dipeptidase (pepV)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902591 (0.E+01)

<400>   1136
Met Thr Ala Ile Asp Phe Thr Ala Glu Val Glu Lys Arg Lys Glu Asp 
1               5                   10                  15      


Leu Leu Ala Asp Leu Phe Ser Leu Leu Glu Ile Asn Ser Glu Arg Asp 
            20                  25                  30          

Asp Ser Lys Ala Asp Ala Gln His Pro Phe Gly Pro Gly Pro Val Lys 
        35                  40                  45              

Ala Leu Glu Lys Phe Leu Glu Ile Ala Asp Arg Asp Gly Tyr Pro Thr 
    50                  55                  60                  

Lys Asn Val Asp Asn Tyr Ala Gly His Phe Glu Phe Gly Asp Gly Glu 
65                  70                  75                  80  

Glu Val Leu Gly Ile Phe Ala His Met Asp Val Val Pro Ala Gly Ser 
                85                  90                  95      

Gly Trp Asp Thr Asp Pro Tyr Thr Pro Thr Ile Lys Asp Gly Arg Leu 
            100                 105                 110         

Tyr Ala Arg Gly Ala Ser Asp Asp Lys Gly Pro Thr Thr Ala Cys Tyr 
        115                 120                 125             

Tyr Gly Leu Lys Ile Ile Lys Glu Leu Gly Leu Pro Thr Ser Lys Lys 
    130                 135                 140                 

Val Arg Phe Ile Val Gly Thr Asp Glu Glu Ser Gly Trp Ala Asp Met 
145                 150                 155                 160 

Asp Tyr Tyr Phe Glu His Val Gly Leu Ala Lys Pro Asp Phe Gly Phe 
                165                 170                 175     

Ser Pro Asp Ala Glu Phe Pro Ile Ile Asn Gly Glu Lys Gly Asn Ile 
            180                 185                 190         

Thr Glu Tyr Leu His Phe Ala Gly Glu Asn Thr Gly Val Ala Arg Leu 
        195                 200                 205             

His Ser Phe Thr Gly Gly Leu Arg Glu Asn Met Val Pro Glu Ser Ala 
    210                 215                 220                 

Thr Ala Val Val Ser Gly Asp Leu Ala Asp Leu Gln Ala Lys Leu Asp 
225                 230                 235                 240 

Ala Phe Val Ala Glu His Lys Leu Arg Gly Glu Leu Gln Glu Glu Ala 
                245                 250                 255     

Gly Lys Tyr Lys Val Thr Ile Ile Gly Lys Ser Ala His Gly Ala Met 
            260                 265                 270         

Pro Ala Ser Gly Val Asn Gly Ala Thr Tyr Leu Ala Leu Phe Leu Ser 
        275                 280                 285             

Gln Phe Gly Phe Ala Gly Pro Ala Lys Asp Tyr Leu Asp Ile Ala Gly 
    290                 295                 300                 

Lys Ile Leu Leu Asn Asp His Glu Gly Glu Asn Leu Lys Ile Ala His 
305                 310                 315                 320 

Val Asp Glu Lys Met Gly Ala Leu Ser Met Asn Ala Gly Val Phe His 
                325                 330                 335     

Phe Asp Glu Thr Ser Ala Asp Asn Thr Ile Ala Leu Asn Ile Arg Tyr 
            340                 345                 350         


Pro Lys Gly Thr Ser Pro Glu Gln Ile Lys Ser Ile Leu Glu Asn Leu 
        355                 360                 365             

Pro Val Val Ser Val Ser Leu Ser Glu His Gly His Thr Pro His Tyr 
    370                 375                 380                 

Val Pro Met Glu Asp Pro Leu Val Gln Thr Leu Leu Asn Ile Tyr Glu 
385                 390                 395                 400 

Lys Gln Thr Gly Phe Lys Gly His Glu Gln Val Ile Gly Gly Gly Thr 
                405                 410                 415     

Phe Gly Arg Leu Leu Glu Arg Gly Val Ala Tyr Gly Ala Met Phe Pro 
            420                 425                 430         

Asp Ser Ile Asp Thr Met His Gln Ala Asn Glu Phe Ile Ala Leu Asp 
        435                 440                 445             

Asp Leu Phe Arg Ala Ala Ala Ile Tyr Ala Glu Ala Ile Tyr Glu Leu 
    450                 455                 460                 

Ile Lys 
465     

<210>   1137
<211>   576
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1137
atgtctcaaa tcgaaagaat caaacaggct atcatggcgg attcgcagaa tgccagctat   60
acagagcgtg gcattgagcc tctctttgca gcgccaaaaa ctgctcgcat caatatcatc   120
ggtcaggctc cgggacttaa aactcaagaa gcaggccttt actggaaaga taaaagtggt   180
gaccgcttgc gggactggct aggtgtggat gaagatacct tttacaattc aggttatttt   240
gctgttttgc ctatggattt ctactttcca ggacatggca agtcgggtga tcttccgcct   300
cgtacaggtt ttgcagaaaa atggcatccg caggtcttac aggaattgcc tgatattcag   360
ttaaccctct tgattgggca atatgcccaa gcctactatt tacaggagaa aatcagtggg   420
aaggtaacgg agagggtgaa acactataaa gactatctgc cagcctattt tccgctagtt   480
cacccatcac cacgaaatca aatctggatg gccaaaaatc cttggtttga ggcagaagta   540
gtgccagatt tgaaaaaaag aattaaaacc atttta                             576

<210>   1138
<211>   192
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902592 (e-111)

<400>   1138
Met Ser Gln Ile Glu Arg Ile Lys Gln Ala Ile Met Ala Asp Ser Gln 
1               5                   10                  15      

Asn Ala Ser Tyr Thr Glu Arg Gly Ile Glu Pro Leu Phe Ala Ala Pro 
            20                  25                  30          

Lys Thr Ala Arg Ile Asn Ile Ile Gly Gln Ala Pro Gly Leu Lys Thr 
        35                  40                  45              

Gln Glu Ala Gly Leu Tyr Trp Lys Asp Lys Ser Gly Asp Arg Leu Arg 
    50                  55                  60                  

Asp Trp Leu Gly Val Asp Glu Asp Thr Phe Tyr Asn Ser Gly Tyr Phe 
65                  70                  75                  80  

Ala Val Leu Pro Met Asp Phe Tyr Phe Pro Gly His Gly Lys Ser Gly 
                85                  90                  95      

Asp Leu Pro Pro Arg Thr Gly Phe Ala Glu Lys Trp His Pro Gln Val 
            100                 105                 110         

Leu Gln Glu Leu Pro Asp Ile Gln Leu Thr Leu Leu Ile Gly Gln Tyr 
        115                 120                 125             

Ala Gln Ala Tyr Tyr Leu Gln Glu Lys Ile Ser Gly Lys Val Thr Glu 
    130                 135                 140                 

Arg Val Lys His Tyr Lys Asp Tyr Leu Pro Ala Tyr Phe Pro Leu Val 
145                 150                 155                 160 

His Pro Ser Pro Arg Asn Gln Ile Trp Met Ala Lys Asn Pro Trp Phe 
                165                 170                 175     

Glu Ala Glu Val Val Pro Asp Leu Lys Lys Arg Ile Lys Thr Ile Leu 
            180                 185                 190         


<210>   1139
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1139
atgaaagaaa tagcctttga cgcattttac cagctttacc aaaacgacca gctttcttta   60
gtggatgtga gagaagtgga tgagtttgca gctcttcatt tagaaggtgc ccacaaccta   120
ccgcttagtc aattggctga tagttatgat taattggaca aagatcgctt gcattatatt   180
atttgcaaat ctggaatgag atcggcgcgt gcttgccaat tcctattaga acaaggttat   240
aatgttatca atgtccaggg tggcatgtta gcctttgaag aactt                   285


<210>   1140
<400>   1140
000

<210>   1141
<211>   1336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1141
atgaaggaga tttttatggc taaaaaaggt accctaacag gtttgctcct gtttggaata   60
ttttttggtg cggggaactt gatttttccg ccttctctag gtgctctatc tggagaacat   120
tttcttcctg ccatcgcagg ttttgtcttt tcaggcgttg gtatcgccgt cttgaccctt   180
attattggaa cgctaaatcc taaaggatat atctacgaga tttcaacgaa gatagcgcct   240
tggtttgcga ctctttacct ctcagttctt tacttgtcaa tcggtccatt ctttgctacc   300
ccacgtactg ctacaacagc ttacgaagta gggattagcc cccttttgtc ggatgcaaat   360
aaaggacttg gcttgattgt atttacggtt ctgtattttg cggcagccta tttgatttcg   420
cttaatccat caaaaatctt agaccgcatt ggacgtattt taacgccagt ctttgcaatt   480
ttgattgtta tcttggtcgt tctgggagct atcaaatatg gtggaacaag tcctcaagct   540
gcttcactgc ttatcaagct tctgcctttg gtacaggttt cctagaaggt tacaatacct   600
tggacgccct tgcctcagtg gcctttagcg taatcgcagt tcaaaccttg aaacaacttg   660
gattttcaag taagaaagaa tacatttcaa ctatttgggt tgttggtatc gttgttgccc   720
ttgccttcag cgctctttac atcggtttag gttttcttgg aaatcatttc ccagtaccag   780
ctgaagcgat gaagggtgga acaccaggtg tttacatctt gtcacaagcc actcaagaaa   840
tctttggctc aacagctcaa ctcttccttg cagctatggt taccgtaacc tgcttcacaa   900
cgactgttgg tttgattgtg tcaacagctg agttctttaa tgagcgcttc ccacaaatca   960
gctacaaggt ttatgcgaca gcctttacct tgattggatt tgctattgcc aatttgggtc   1020
ttgatgcgat tatcaagtac tcaattccag tactggttat cttgtaccca atcacgattg   1080
ctatcgttat gattgtcatt gtcaacaaat ttgttgccct ttcaaaacca ggtatgcagt   1140
tgacaattgc tgtggttaca gttattgcca ttgcaagcgt actaggaagc tcgttaaggt   1200
tgagtttctt gcaaatcttg ttagcgttct tccttttgcc aaggcatctc tcccatggtt   1260
ggtgccagcc attgttggaa tcttgctctc attggttcta ccaaacaagc aagaaagcga   1320
tgtttttgaa atggaa                                                   1336

<210>   1142
<211>   194
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   branched-chain amino acid transporter, FRAMESHIFT

<400>   1142
Met Lys Glu Ile Phe Met Ala Lys Lys Gly Thr Leu Thr Gly Leu Leu 
1               5                   10                  15      

Leu Phe Gly Ile Phe Phe Gly Ala Gly Asn Leu Ile Phe Pro Pro Ser 
            20                  25                  30          

Leu Gly Ala Leu Ser Gly Glu His Phe Leu Pro Ala Ile Ala Gly Phe 
        35                  40                  45              

Val Phe Ser Gly Val Gly Ile Ala Val Leu Thr Leu Ile Ile Gly Thr 
    50                  55                  60                  

Leu Asn Pro Lys Gly Tyr Ile Tyr Glu Ile Ser Thr Lys Ile Ala Pro 
65                  70                  75                  80  

Trp Phe Ala Thr Leu Tyr Leu Ser Val Leu Tyr Leu Ser Ile Gly Pro 
                85                  90                  95      

Phe Phe Ala Thr Pro Arg Thr Ala Thr Thr Ala Tyr Glu Val Gly Ile 
            100                 105                 110         

Ser Pro Leu Leu Ser Asp Ala Asn Lys Gly Leu Gly Leu Ile Val Phe 
        115                 120                 125             

Thr Val Leu Tyr Phe Ala Ala Ala Tyr Leu Ile Ser Leu Asn Pro Ser 
    130                 135                 140                 

Lys Ile Leu Asp Arg Ile Gly Arg Ile Leu Thr Pro Val Phe Ala Ile 
145                 150                 155                 160 

Leu Ile Val Ile Leu Val Val Leu Gly Ala Ile Lys Tyr Gly Gly Thr 
                165                 170                 175     

Ser Pro Gln Ala Ala Ser Leu Leu Ile Lys Leu Leu Pro Leu Val Gln 
            180                 185                 190         

Val Ser 
        

<210>   1143
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1143
gtgattattc catttcaaaa acatcgcttt cttgcttgtt tggtagaacc aatgagagca   60
agattccaac aatggctggc accaaccatg ggagagatgc cttggcaaaa ggaagaacgc   120

<210>   1144
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1144
Met Ile Ile Pro Phe Gln Lys His Arg Phe Leu Ala Cys Leu Val Glu 
1               5                   10                  15      

Pro Met Arg Ala Arg Phe Gln Gln Trp Leu Ala Pro Thr Met Gly Glu 
            20                  25                  30          

Met Pro Trp Gln Lys Glu Glu Arg 
        35                  40  

<210>   1145
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1145
ttgtttggta gaaccaatga gagcaagatt ccaacaatgg ctggcaccaa ccatgggaga   60
gatgccttgg caaaaggaag aacgctaaca agatttgcaa gaaactcaac cttaacgagc   120
ttcctagtac gcttgcaatg gcaa                                          144

<210>   1146
<211>   48
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1146
Met Phe Gly Arg Thr Asn Glu Ser Lys Ile Pro Thr Met Ala Gly Thr 
1               5                   10                  15      

Asn His Gly Arg Asp Ala Leu Ala Lys Gly Arg Thr Leu Thr Arg Phe 
            20                  25                  30          

Ala Arg Asn Ser Thr Leu Thr Ser Phe Leu Val Arg Leu Gln Trp Gln 
        35                  40                  45              


<210>   1147
<211>   1035
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1147
atgaatcaaa cagtagaata tatcaaagaa ctgacagcca ttgcgtcgcc aacaggcttt   60
actcgtgaga ttgcggacta tttagtcaag actctagaag gttttggtta ccagccggtt   120
cgcacatcca agggcggtgt caatgtaact attaaaggtc aaaatgatga gcaacatcgc   180
tatgtgactg cccatgtaga tacgcttggt gctattgtcc gtgctgtcaa accagacggc   240
cgtctcaaaa tggaccgtat cggtggcttt ccttggaaca tgattgaagg agaaaactgt   300
accattcatg tggctagcac aggtgaaaaa gtatcaggaa ccatcctcat ccaccaaact   360
tcttgccatg tctataagga tgcaggaact gcagaacgca cgcaagacaa tatggaagtg   420
cgtttggacg ccaaagtaac tagtgaaaaa gaaactcgtg ctcttggcat tgaggtcggt   480
gattttatca gttttgaccc acgaactgtc gtgacagaga caggttttat caagtctcgc   540
catttggatg acaaggtcag tgcggcgatt ttgctcaatc tccttcgcat ttataaggaa   600
gagaagattg aattgcccgt aacaactcat tttgcttttt cagtctttga agaagtggga   660
cacggtgcaa actctaacat tcctgctcag gtagtagaat atctggctgt ggatatggga   720
gccatgggag atgaccagca aacagacgaa tatacagtgt ctatctgtgt caaggatgct   780
tctggacctt atcactatga cttccgtcaa catttggtgg ctttggcgaa agagcaagat   840
attccattta agctggatat ctatccattt tatggttcgg acgcttcagc ggctatgtct   900
gcaggggcag aagtcaaaca cgcccttctc ggtgctggta tagagtctag ccattcctat   960
gagcgtaccc atattgactc ggtgatcgca acagaacgaa tggtcgatgc ttatcttaag   1020
agcacgttgg tggac                                                    1035

<210>   1148
<211>   345
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902596 (0.E+01)

<400>   1148
Met Asn Gln Thr Val Glu Tyr Ile Lys Glu Leu Thr Ala Ile Ala Ser 
1               5                   10                  15      

Pro Thr Gly Phe Thr Arg Glu Ile Ala Asp Tyr Leu Val Lys Thr Leu 
            20                  25                  30          

Glu Gly Phe Gly Tyr Gln Pro Val Arg Thr Ser Lys Gly Gly Val Asn 
        35                  40                  45              

Val Thr Ile Lys Gly Gln Asn Asp Glu Gln His Arg Tyr Val Thr Ala 
    50                  55                  60                  

His Val Asp Thr Leu Gly Ala Ile Val Arg Ala Val Lys Pro Asp Gly 
65                  70                  75                  80  

Arg Leu Lys Met Asp Arg Ile Gly Gly Phe Pro Trp Asn Met Ile Glu 
                85                  90                  95      

Gly Glu Asn Cys Thr Ile His Val Ala Ser Thr Gly Glu Lys Val Ser 
            100                 105                 110         

Gly Thr Ile Leu Ile His Gln Thr Ser Cys His Val Tyr Lys Asp Ala 
        115                 120                 125             

Gly Thr Ala Glu Arg Thr Gln Asp Asn Met Glu Val Arg Leu Asp Ala 
    130                 135                 140                 

Lys Val Thr Ser Glu Lys Glu Thr Arg Ala Leu Gly Ile Glu Val Gly 
145                 150                 155                 160 

Asp Phe Ile Ser Phe Asp Pro Arg Thr Val Val Thr Glu Thr Gly Phe 
                165                 170                 175     

Ile Lys Ser Arg His Leu Asp Asp Lys Val Ser Ala Ala Ile Leu Leu 
            180                 185                 190         

Asn Leu Leu Arg Ile Tyr Lys Glu Glu Lys Ile Glu Leu Pro Val Thr 
        195                 200                 205             

Thr His Phe Ala Phe Ser Val Phe Glu Glu Val Gly His Gly Ala Asn 
    210                 215                 220                 

Ser Asn Ile Pro Ala Gln Val Val Glu Tyr Leu Ala Val Asp Met Gly 
225                 230                 235                 240 

Ala Met Gly Asp Asp Gln Gln Thr Asp Glu Tyr Thr Val Ser Ile Cys 
                245                 250                 255     

Val Lys Asp Ala Ser Gly Pro Tyr His Tyr Asp Phe Arg Gln His Leu 
            260                 265                 270         

Val Ala Leu Ala Lys Glu Gln Asp Ile Pro Phe Lys Leu Asp Ile Tyr 
        275                 280                 285             

Pro Phe Tyr Gly Ser Asp Ala Ser Ala Ala Met Ser Ala Gly Ala Glu 
    290                 295                 300                 

Val Lys His Ala Leu Leu Gly Ala Gly Ile Glu Ser Ser His Ser Tyr 
305                 310                 315                 320 

Glu Arg Thr His Ile Asp Ser Val Ile Ala Thr Glu Arg Met Val Asp 
                325                 330                 335     

Ala Tyr Leu Lys Ser Thr Leu Val Asp 
            340                 345 

<210>   1149
<211>   501
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1149
atgcttatct taagagcacg ttggtggact aatatgtgcc ttatttgtca gagaattgac   60
ctcatcaaga aggaagaaaa tccttacttt gtcaaagagt tggaaacagg ctatcttgtg   120
gttggagacc accagtattt tgaaggctat agtctctttc tagccaagga gcatgtcagc   180
gaattgcacc atttgaaaaa ggagacaaga ctccgttttc tagaagaaat gagtttagtc   240
caagaggcag ttgccaaggc ctttgctgct gagaaaatga atatcgaact gctaggaaat   300
ggcgatgctc atcttcattg gcatctgttt ccacgacgga caggtgatat gaatggtcat   360
ggtctcaagg gtcgtggacc agtctggtgg gttccctttg aagaaatgac agcagaaacc   420
tgccaagcaa aaccggatga gattaaaaga ttagtcaaac gtttatcgtc agaagtagat   480
aaactattag aaataaagga g                                             501

<210>   1150
<211>   167
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   HIT family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902597 (8.E-98)

<400>   1150
Met Leu Ile Leu Arg Ala Arg Trp Trp Thr Asn Met Cys Leu Ile Cys 
1               5                   10                  15      

Gln Arg Ile Asp Leu Ile Lys Lys Glu Glu Asn Pro Tyr Phe Val Lys 
            20                  25                  30          

Glu Leu Glu Thr Gly Tyr Leu Val Val Gly Asp His Gln Tyr Phe Glu 
        35                  40                  45              

Gly Tyr Ser Leu Phe Leu Ala Lys Glu His Val Ser Glu Leu His His 
    50                  55                  60                  

Leu Lys Lys Glu Thr Arg Leu Arg Phe Leu Glu Glu Met Ser Leu Val 
65                  70                  75                  80  

Gln Glu Ala Val Ala Lys Ala Phe Ala Ala Glu Lys Met Asn Ile Glu 
                85                  90                  95      

Leu Leu Gly Asn Gly Asp Ala His Leu His Trp His Leu Phe Pro Arg 
            100                 105                 110         

Arg Thr Gly Asp Met Asn Gly His Gly Leu Lys Gly Arg Gly Pro Val 
        115                 120                 125             

Trp Trp Val Pro Phe Glu Glu Met Thr Ala Glu Thr Cys Gln Ala Lys 
    130                 135                 140                 

Pro Asp Glu Ile Lys Arg Leu Val Lys Arg Leu Ser Ser Glu Val Asp 
145                 150                 155                 160 

Lys Leu Leu Glu Ile Lys Glu 
                165         

<210>   1151
<211>   714
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1151
atgaagaaaa gatacctagt cttgacagct ttgctagcct tgagtctagc agcttgttca   60
caagaaaaaa caaaaaatga agatggagaa actaagacag aacagacagc caaagctgat   120
ggaacagtcg gtagtaagtc tcaaggagct gcccagaaga aagcagaagt ggtcaataaa   180
ggtgattact acagcattca agggaaatac gatgaaatca tcgtagccaa caaacactat   240
ccattgtcta aagactataa tccaggggaa aatccaacag ccaaggcaga gttggtcaaa   300
ctcatcaaag cgatgcaaga ggcaggtttc cctattagtg atcattacag tggttttaga   360
agttatgaaa ctcagaccaa gctctatcaa gattatgtca accaagatgg aaaggcagca   420
gctgaccgtt actctgcccg tcctggctat agcgaacacc agacaggctt ggcctttgat   480
gtgattggga ctgatggtga tttggtgaca gaagaaaaag cagcccaatg gctcttggat   540
catgcagctg attatggctt tgttgtccgt tatctcaaag gcaaggaaaa ggaaacaggc   600
tatatggctg aagaatggca cctgcgttat gtaggaaaag aagctaaaga aattgctgca   660
agtggtctca gtttggaaga atactatggc tttgaaggcg gagactacgt cgat         714

<210>   1152
<211>   238
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902598 (e-137)

<400>   1152
Met Lys Lys Arg Tyr Leu Val Leu Thr Ala Leu Leu Ala Leu Ser Leu 
1               5                   10                  15      

Ala Ala Cys Ser Gln Glu Lys Thr Lys Asn Glu Asp Gly Glu Thr Lys 
            20                  25                  30          

Thr Glu Gln Thr Ala Lys Ala Asp Gly Thr Val Gly Ser Lys Ser Gln 
        35                  40                  45              

Gly Ala Ala Gln Lys Lys Ala Glu Val Val Asn Lys Gly Asp Tyr Tyr 
    50                  55                  60                  

Ser Ile Gln Gly Lys Tyr Asp Glu Ile Ile Val Ala Asn Lys His Tyr 
65                  70                  75                  80  

Pro Leu Ser Lys Asp Tyr Asn Pro Gly Glu Asn Pro Thr Ala Lys Ala 
                85                  90                  95      

Glu Leu Val Lys Leu Ile Lys Ala Met Gln Glu Ala Gly Phe Pro Ile 
            100                 105                 110         

Ser Asp His Tyr Ser Gly Phe Arg Ser Tyr Glu Thr Gln Thr Lys Leu 
        115                 120                 125             

Tyr Gln Asp Tyr Val Asn Gln Asp Gly Lys Ala Ala Ala Asp Arg Tyr 
    130                 135                 140                 

Ser Ala Arg Pro Gly Tyr Ser Glu His Gln Thr Gly Leu Ala Phe Asp 
145                 150                 155                 160 

Val Ile Gly Thr Asp Gly Asp Leu Val Thr Glu Glu Lys Ala Ala Gln 
                165                 170                 175     

Trp Leu Leu Asp His Ala Ala Asp Tyr Gly Phe Val Val Arg Tyr Leu 
            180                 185                 190         

Lys Gly Lys Glu Lys Glu Thr Gly Tyr Met Ala Glu Glu Trp His Leu 
        195                 200                 205             

Arg Tyr Val Gly Lys Glu Ala Lys Glu Ile Ala Ala Ser Gly Leu Ser 
    210                 215                 220                 

Leu Glu Glu Tyr Tyr Gly Phe Glu Gly Gly Asp Tyr Val Asp 
225                 230                 235             

<210>   1153
<211>   222
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1153
atggctttga aggcggagac tacgtcgatt aatactcttc gaaaatctct tcaaaccacg   60
tcagcgtcgc cttacctact gactgcgtcg gttctattca caacctcaaa acagtgtttt   120
gagctgactt cgtcagtttt atctgcaacc tcaaagctgt actttgagca gcctgcggct   180
agcttcctag tttgctcttt gattttcatt gagtacaaaa ag                      222

<210>   1154
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1154
Met Ala Leu Lys Ala Glu Thr Thr Ser Ile Asn Thr Leu Arg Lys Ser 
1               5                   10                  15      

Leu Gln Thr Thr Ser Ala Ser Pro Tyr Leu Leu Thr Ala Ser Val Leu 
            20                  25                  30          

Phe Thr Thr Ser Lys Gln Cys Phe Glu Leu Thr Ser Ser Val Leu Ser 
        35                  40                  45              

Ala Thr Ser Lys Leu Tyr Phe Glu Gln Pro Ala Ala Ser Phe Leu Val 
    50                  55                  60                  

Cys Ser Leu Ile Phe Ile Glu Tyr Lys Lys 
65                  70                  

<210>   1155
<211>   423
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1155
atggctaaaa aagtcgaaaa acttgtaaaa ttgcaaatcc ctgctggtaa agctacacca   60
gctccaccgg ttggacctgc tcttggtcaa gctggtatca acatcatggg attcacaaaa   120
gagttcaacg ctcgtacagc tgaccaagct ggtatgatca ttccagttgt tatctcagtt   180
tacgaagata aatcatttac tttcgttacg aaaacaccac cagctgctgt tcttttgaaa   240
aaagctgcag gtgttgaaaa aggatcaggt acacctaata aaactaaagt tgctacagtt   300
actcgtgcac aagtacaaga aattgcagaa actaagatgc cagatttgaa cgcagcaaac   360
gtagagtctg caatgcgtat gatcgaaggt actgctcgtt ctatgggatt cactgttgtt   420
gac                                                                 423

<210>   1156
<211>   141
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L11 (rplK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902599 (2.E-75)

<400>   1156
Met Ala Lys Lys Val Glu Lys Leu Val Lys Leu Gln Ile Pro Ala Gly 
1               5                   10                  15      

Lys Ala Thr Pro Ala Pro Pro Val Gly Pro Ala Leu Gly Gln Ala Gly 
            20                  25                  30          

Ile Asn Ile Met Gly Phe Thr Lys Glu Phe Asn Ala Arg Thr Ala Asp 
        35                  40                  45              

Gln Ala Gly Met Ile Ile Pro Val Val Ile Ser Val Tyr Glu Asp Lys 
    50                  55                  60                  

Ser Phe Thr Phe Val Thr Lys Thr Pro Pro Ala Ala Val Leu Leu Lys 
65                  70                  75                  80  

Lys Ala Ala Gly Val Glu Lys Gly Ser Gly Thr Pro Asn Lys Thr Lys 
                85                  90                  95      

Val Ala Thr Val Thr Arg Ala Gln Val Gln Glu Ile Ala Glu Thr Lys 
            100                 105                 110         

Met Pro Asp Leu Asn Ala Ala Asn Val Glu Ser Ala Met Arg Met Ile 
        115                 120                 125             

Glu Gly Thr Ala Arg Ser Met Gly Phe Thr Val Val Asp 
    130                 135                 140     

<210>   1157
<211>   687
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1157
atggctaaaa aaagcaaaca acttcgtgct gctcttgaga aaatcgacag cacaaaagca   60
tacagtgtag aagaagctgt agcacttgca aaagaaacta actttgcaaa atttgatgca   120
actgtagaag ttgcttacaa cttgaacatc gacgttaaaa aagctgacca acaaatccgt   180
ggagcaatgg tattgccaaa cggtactggt aaaacttcac gtgttcttgt tttcgcacgt   240
ggtgcaaaag ctgaagaagc aaaagctgct ggtgcagact ttgttggtga agatgacctt   300
gttgctaaaa tcaacgacgg ttggttggac ttcgacgtag ttatcgctac acctgatatg   360
atggctcttg ttggacgtct tggacgtgtc cttggaccac gtaacttgat gccaaaccct   420
aaaactggta ctgtaacaat ggatgttgct aaagcagttg aagagtctaa aggtggtaaa   480
atcacttacc gtgctgaccg tgcaggtaac gttcaagcaa tcatcggtaa agtatcattt   540
gaagctgaaa aattggttga aaactttaaa gctttcaacg aaacaatcca aaaagcaaaa   600
ccagctacag ctaaaggaac ttacgtaaca aacttgacta tcacaactac tcaaggtgtt   660
ggtatcaaag ttgacgtaaa ctcactt                                       687

<210>   1158
<211>   229
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L1 (rplA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902600 (e-125)

<400>   1158
Met Ala Lys Lys Ser Lys Gln Leu Arg Ala Ala Leu Glu Lys Ile Asp 
1               5                   10                  15      

Ser Thr Lys Ala Tyr Ser Val Glu Glu Ala Val Ala Leu Ala Lys Glu 
            20                  25                  30          

Thr Asn Phe Ala Lys Phe Asp Ala Thr Val Glu Val Ala Tyr Asn Leu 
        35                  40                  45              

Asn Ile Asp Val Lys Lys Ala Asp Gln Gln Ile Arg Gly Ala Met Val 
    50                  55                  60                  

Leu Pro Asn Gly Thr Gly Lys Thr Ser Arg Val Leu Val Phe Ala Arg 
65                  70                  75                  80  

Gly Ala Lys Ala Glu Glu Ala Lys Ala Ala Gly Ala Asp Phe Val Gly 
                85                  90                  95      

Glu Asp Asp Leu Val Ala Lys Ile Asn Asp Gly Trp Leu Asp Phe Asp 
            100                 105                 110         

Val Val Ile Ala Thr Pro Asp Met Met Ala Leu Val Gly Arg Leu Gly 
        115                 120                 125             

Arg Val Leu Gly Pro Arg Asn Leu Met Pro Asn Pro Lys Thr Gly Thr 
    130                 135                 140                 

Val Thr Met Asp Val Ala Lys Ala Val Glu Glu Ser Lys Gly Gly Lys 
145                 150                 155                 160 

Ile Thr Tyr Arg Ala Asp Arg Ala Gly Asn Val Gln Ala Ile Ile Gly 
                165                 170                 175     

Lys Val Ser Phe Glu Ala Glu Lys Leu Val Glu Asn Phe Lys Ala Phe 
            180                 185                 190         

Asn Glu Thr Ile Gln Lys Ala Lys Pro Ala Thr Ala Lys Gly Thr Tyr 
        195                 200                 205             

Val Thr Asn Leu Thr Ile Thr Thr Thr Gln Gly Val Gly Ile Lys Val 
    210                 215                 220                 

Asp Val Asn Ser Leu 
225                 

<210>   1159
<211>   201
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1159
gtgttatact caatgaaaac caaagagcaa actaggaaac tagccgcagg ttgctcaaaa   60
cactgttttg aggttgtaga tggaactgac gtagtcagct caaaacactg ttttgaggtt   120
gtggatagaa ctgacgaagt cagtaaccat acgcacggca aggcgacgtt gacgtggttt   180
gaagagattt tcgaagagta t                                             201

<210>   1160
<211>   67
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1160
Met Leu Tyr Ser Met Lys Thr Lys Glu Gln Thr Arg Lys Leu Ala Ala 
1               5                   10                  15      

Gly Cys Ser Lys His Cys Phe Glu Val Val Asp Gly Thr Asp Val Val 
            20                  25                  30          

Ser Ser Lys His Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser 
        35                  40                  45              

Asn His Thr His Gly Lys Ala Thr Leu Thr Trp Phe Glu Glu Ile Phe 
    50                  55                  60                  

Glu Glu Tyr 
65          

<210>   1161
<211>   360
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1161
ttgttagaag ttggtttaaa tttcctaatc agtttgttca catttacctt cgatatatta   60
tatcccatag ttaaggttgg tcatacagat gattatagtc atggagccgt aaaacttagt   120
gtttctttag ttgacaaaga tgccatgaaa aaaatatttg taactgtaat aggatatttt   180
gaaataaata tagatgaaaa tatcaccgat attctatacg taaatggtac tgctattctt   240
tatctttatt tacgttcaat tgtttcaata gtttcggcaa ttgatagcag tgaagcaatg   300
ttgctaccta tcattaatgt tttagagtta ctagataaat ctcaaccttt tgaagaagaa   360

<210>   1162
<211>   120
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   1162
Met Leu Glu Val Gly Leu Asn Phe Leu Ile Ser Leu Phe Thr Phe Thr 
1               5                   10                  15      

Phe Asp Ile Leu Tyr Pro Ile Val Lys Val Gly His Thr Asp Asp Tyr 
            20                  25                  30          

Ser His Gly Ala Val Lys Leu Ser Val Ser Leu Val Asp Lys Asp Ala 
        35                  40                  45              

Met Lys Lys Ile Phe Val Thr Val Ile Gly Tyr Phe Glu Ile Asn Ile 
    50                  55                  60                  

Asp Glu Asn Ile Thr Asp Ile Leu Tyr Val Asn Gly Thr Ala Ile Leu 
65                  70                  75                  80  

Tyr Leu Tyr Leu Arg Ser Ile Val Ser Ile Val Ser Ala Ile Asp Ser 
                85                  90                  95      

Ser Glu Ala Met Leu Leu Pro Ile Ile Asn Val Leu Glu Leu Leu Asp 
            100                 105                 110         

Lys Ser Gln Pro Phe Glu Glu Glu 
        115                 120 

<210>   1163

<211>   339
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1163
ttgttctcat cttatttcaa tccgctatat attatggtat cgaatcttca tcagaatgat   60
aaaattaatc aattgatatc tgattacaaa cagaatatga aagcttttta tatcactatt   120
gaaaaattta tacgagatga tgaaagcctt aagtgttatt ttataaaggt tatttcaagt   180
cgttccaagg taacaagtct agatcagatt gaagctgata aaacgataca aagaaaatat   240
tcaagtgagc taaaaaaatt tattggattt tataatgaga ttatttgtga ggaaaatagt   300
ttcctacatg tacgaaagag gtggtcgagt tggtttagg                          339

<210>   1164
<211>   113
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm

<400>   1164
Met Phe Ser Ser Tyr Phe Asn Pro Leu Tyr Ile Met Val Ser Asn Leu 
1               5                   10                  15      

His Gln Asn Asp Lys Ile Asn Gln Leu Ile Ser Asp Tyr Lys Gln Asn 
            20                  25                  30          

Met Lys Ala Phe Tyr Ile Thr Ile Glu Lys Phe Ile Arg Asp Asp Glu 
        35                  40                  45              

Ser Leu Lys Cys Tyr Phe Ile Lys Val Ile Ser Ser Arg Ser Lys Val 
    50                  55                  60                  

Thr Ser Leu Asp Gln Ile Glu Ala Asp Lys Thr Ile Gln Arg Lys Tyr 
65                  70                  75                  80  

Ser Ser Glu Leu Lys Lys Phe Ile Gly Phe Tyr Asn Glu Ile Ile Cys 
                85                  90                  95      

Glu Glu Asn Ser Phe Leu His Val Arg Lys Arg Trp Ser Ser Trp Phe 
            100                 105                 110         

Arg 
    

<210>   1165
<211>   165
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1165
atgctcagaa tgattgtctc taaacaatac ctgctctttt acctcattca tgaaaaagaa   60
gtccataccc tgagaattat caactcacgc atcgactacc taaaccaact cgaccacctc   120
tttcgtacat gtaggaaact attttcctca caaataatct catta                   165

<210>   1166
<211>   55
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1166
Met Leu Arg Met Ile Val Ser Lys Gln Tyr Leu Leu Phe Tyr Leu Ile 
1               5                   10                  15      

His Glu Lys Glu Val His Thr Leu Arg Ile Ile Asn Ser Arg Ile Asp 
            20                  25                  30          


Tyr Leu Asn Gln Leu Asp His Leu Phe Arg Thr Cys Arg Lys Leu Phe 
        35                  40                  45              

Ser Ser Gln Ile Ile Ser Leu 
    50                  55  

<210>   1167
<211>   990
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1167
atggcaatga tagaagtgga acatcttcag aaaaattttg tgaagactgt taaggaaccg   60
ggcttgaagg gggctttgcg ctcctttatt catcctgaaa agcagacctt tgaagcggtc   120
aaggatttga cctttgaggt tccaaaaggg cagattttag gatttatcgg ggcaaatggt   180
gctgggaagt cgacaaccat taaaatgctg acaggaattt tgaaaccaac atctggtttt   240
tgtcggatta acggcaagat tccccaggac aatcggcaag attatgtcaa agatattggc   300
gtagtctttg gacaacgcac ccagctatgg tgggatttgg ctctgcaaga gacctacact   360
gtcttaaaag agatttatga tgtgccagac tcgctctttc ataagcgtat ggactttttg   420
aatgaagtct tggatttgaa ggactttatc aaggatcccg tgcggactct ttcactggga   480
caacggatgc gggcggatat tgcggcctcc ttgctccaca atcccaaggt tcttttttta   540
gatgagccga ccattggttt ggacgtttcg gttaaggata atattcgtcg ggcaattact   600
cagatcaatc aagaggaaga aactaccatt cttttgacca ctcacgattt gagtgatatt   660
gagcaacttt gtgatcggat tttcatgatt gacaaggggc aagagatttt tgatggaacg   720
gtgagccaac tcaaggagac ctttggtaag atgaagactc tctcttttga actgctacca   780
ggtcaaagtc atctcgtctc tcactatgac ggtctgtctg atatgaccat tgatagacaa   840
ggaaacagcc tcaacattga atttgatagt tctcgctacc agtcagctga cattatcaag   900
caaaccctgt ctgattttga aatccgcgat ttgaagatgg tggatacgga tattgaggat   960
attatccgtc gcttctaccg aaaggagctc                                    990

<210>   1168
<211>   330
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902601 (0.E+01)

<400>   1168
Met Ala Met Ile Glu Val Glu His Leu Gln Lys Asn Phe Val Lys Thr 
1               5                   10                  15      

Val Lys Glu Pro Gly Leu Lys Gly Ala Leu Arg Ser Phe Ile His Pro 
            20                  25                  30          

Glu Lys Gln Thr Phe Glu Ala Val Lys Asp Leu Thr Phe Glu Val Pro 
        35                  40                  45              

Lys Gly Gln Ile Leu Gly Phe Ile Gly Ala Asn Gly Ala Gly Lys Ser 
    50                  55                  60                  

Thr Thr Ile Lys Met Leu Thr Gly Ile Leu Lys Pro Thr Ser Gly Phe 
65                  70                  75                  80  

Cys Arg Ile Asn Gly Lys Ile Pro Gln Asp Asn Arg Gln Asp Tyr Val 
                85                  90                  95      

Lys Asp Ile Gly Val Val Phe Gly Gln Arg Thr Gln Leu Trp Trp Asp 
            100                 105                 110         

Leu Ala Leu Gln Glu Thr Tyr Thr Val Leu Lys Glu Ile Tyr Asp Val 
        115                 120                 125             

Pro Asp Ser Leu Phe His Lys Arg Met Asp Phe Leu Asn Glu Val Leu 
    130                 135                 140                 

Asp Leu Lys Asp Phe Ile Lys Asp Pro Val Arg Thr Leu Ser Leu Gly 
145                 150                 155                 160 

Gln Arg Met Arg Ala Asp Ile Ala Ala Ser Leu Leu His Asn Pro Lys 
                165                 170                 175     

Val Leu Phe Leu Asp Glu Pro Thr Ile Gly Leu Asp Val Ser Val Lys 
            180                 185                 190         

Asp Asn Ile Arg Arg Ala Ile Thr Gln Ile Asn Gln Glu Glu Glu Thr 
        195                 200                 205             

Thr Ile Leu Leu Thr Thr His Asp Leu Ser Asp Ile Glu Gln Leu Cys 
    210                 215                 220                 

Asp Arg Ile Phe Met Ile Asp Lys Gly Gln Glu Ile Phe Asp Gly Thr 
225                 230                 235                 240 

Val Ser Gln Leu Lys Glu Thr Phe Gly Lys Met Lys Thr Leu Ser Phe 
                245                 250                 255     

Glu Leu Leu Pro Gly Gln Ser His Leu Val Ser His Tyr Asp Gly Leu 
            260                 265                 270         

Ser Asp Met Thr Ile Asp Arg Gln Gly Asn Ser Leu Asn Ile Glu Phe 
        275                 280                 285             

Asp Ser Ser Arg Tyr Gln Ser Ala Asp Ile Ile Lys Gln Thr Leu Ser 
    290                 295                 300                 

Asp Phe Glu Ile Arg Asp Leu Lys Met Val Asp Thr Asp Ile Glu Asp 
305                 310                 315                 320 

Ile Ile Arg Arg Phe Tyr Arg Lys Glu Leu 
                325                 330 

<210>   1169
<211>   858
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1169
ttgaggatat tatccgtcgc ttctaccgaa aggagctcta ggatgatcaa attgtggaga   60
cgttataaac cctttatcaa tgcaggggtt caggagttga ttacttaccg agtcaacttt   120
attctctatc ggattggcga tgtcatgggg gcttttgtgg ccttttatct ctggaaggct   180
gtctttgatt cttcgcaaga gtctttgatt cagggcttca gtatggcgga tatcaccctc   240
tacatcatca tgagttttgt gaccaatctt ctgactagat ccgattcgtc ctttatgatt   300
ggggaggagg tcaaggatgg ctccattatc atgcgtttgt tgcgaccagt gcattttgcg   360
gcctcctatc ttttcaccga gcttggttcc aagtggttga tttttatcag cgttggcctt   420
ccatttttaa gtgtcattgt cttgatgaaa atcatatcgg gtcaaggtat tgtagaggtg   480
ctaggattaa ctgtcattta tctttttagc ttaacgctcg cctatctgat taactttttc   540
tttaatattt gctttggatt ttcagccttt gtgtttaaaa atctttgggg ttccaaccta   600
cttaagactt ccatagtggc ttttatgtcg gggagtttga ttcccttggc attttttcca   660
aaggttgttt cagatattct ctcctttttg cctttttcat ccttgattta tactccagtt   720
atgatcattg ttggaaaata cgatgccagt cagattcttc aggcactcct tttgcagttc   780
ttctggctct tagtgatggt gggattgtct cagttaattt ggaaacgggt ccagtccttt   840
atcaccattc aaggaggt                                                 858

<210>   1170
<211>   286
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902602 (e-152)

<400>   1170
Met Arg Ile Leu Ser Val Ala Ser Thr Glu Arg Ser Ser Arg Met Ile 
1               5                   10                  15      

Lys Leu Trp Arg Arg Tyr Lys Pro Phe Ile Asn Ala Gly Val Gln Glu 
            20                  25                  30          

Leu Ile Thr Tyr Arg Val Asn Phe Ile Leu Tyr Arg Ile Gly Asp Val 
        35                  40                  45              

Met Gly Ala Phe Val Ala Phe Tyr Leu Trp Lys Ala Val Phe Asp Ser 
    50                  55                  60                  

Ser Gln Glu Ser Leu Ile Gln Gly Phe Ser Met Ala Asp Ile Thr Leu 
65                  70                  75                  80  

Tyr Ile Ile Met Ser Phe Val Thr Asn Leu Leu Thr Arg Ser Asp Ser 
                85                  90                  95      

Ser Phe Met Ile Gly Glu Glu Val Lys Asp Gly Ser Ile Ile Met Arg 
            100                 105                 110         

Leu Leu Arg Pro Val His Phe Ala Ala Ser Tyr Leu Phe Thr Glu Leu 
        115                 120                 125             

Gly Ser Lys Trp Leu Ile Phe Ile Ser Val Gly Leu Pro Phe Leu Ser 
    130                 135                 140                 

Val Ile Val Leu Met Lys Ile Ile Ser Gly Gln Gly Ile Val Glu Val 
145                 150                 155                 160 

Leu Gly Leu Thr Val Ile Tyr Leu Phe Ser Leu Thr Leu Ala Tyr Leu 
                165                 170                 175     

Ile Asn Phe Phe Phe Asn Ile Cys Phe Gly Phe Ser Ala Phe Val Phe 
            180                 185                 190         

Lys Asn Leu Trp Gly Ser Asn Leu Leu Lys Thr Ser Ile Val Ala Phe 
        195                 200                 205             

Met Ser Gly Ser Leu Ile Pro Leu Ala Phe Phe Pro Lys Val Val Ser 
    210                 215                 220                 

Asp Ile Leu Ser Phe Leu Pro Phe Ser Ser Leu Ile Tyr Thr Pro Val 
225                 230                 235                 240 

Met Ile Ile Val Gly Lys Tyr Asp Ala Ser Gln Ile Leu Gln Ala Leu 
                245                 250                 255     

Leu Leu Gln Phe Phe Trp Leu Leu Val Met Val Gly Leu Ser Gln Leu 
            260                 265                 270         

Ile Trp Lys Arg Val Gln Ser Phe Ile Thr Ile Gln Gly Gly 
        275                 280                 285     

<210>   1171
<211>   783
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1171
atgaaaaaat atcaacgaat gcatctgatt tttatcagac aatacatcaa acaaatcatg   60
gaatataagg tagattttgt ggttggtgtc ttgggagtct ttctgactca aggcttgaat   120
ctcttgtttc tcaatgtcat ctttcaacat attccattcc tagaaggctg gacctttcaa   180
gagatagctt tcatttatgg attttccttg attcccaagg gaatggacca tctctttttt   240
gacaatctct gggcactagg gcaacgccta gtccgaaaag gggagtttga caagtatctg   300
actcgtccca tcaatcctct ctttcacatc ctagttgaaa cctttcagat tgatgccttg   360
ggtgaactct tagtcggtgg tattttattg ggaacaacag tgaccagcat tgtttggact   420
cttccaaaat tcctgctttt cctagtttgt attccttttg cgaccttgat ttatacttct   480
cttaaaatcg caacagccag tatcgccttt tggactaagc agtcaggcgc catgatttac   540
atcttctata tgttcaatga ctttgctaag tatccgattt ctatttacaa ttctcttctt   600
cgttggttga ttagctttat cgtgcctttc gcctttacag cctactatcc agctagctat   660
ttcttacagg aaaaggatgt gttctttaac gtaggaggtt tgatgttgat ttctctggtt   720
ttctttgtta tttcccttaa actttgggat aagggcttag attcctacga aagtgcgggt   780
tcg                                                                 783

<210>   1172
<211>   261
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902603 (e-151)

<400>   1172
Met Lys Lys Tyr Gln Arg Met His Leu Ile Phe Ile Arg Gln Tyr Ile 
1               5                   10                  15      

Lys Gln Ile Met Glu Tyr Lys Val Asp Phe Val Val Gly Val Leu Gly 
            20                  25                  30          

Val Phe Leu Thr Gln Gly Leu Asn Leu Leu Phe Leu Asn Val Ile Phe 
        35                  40                  45              

Gln His Ile Pro Phe Leu Glu Gly Trp Thr Phe Gln Glu Ile Ala Phe 
    50                  55                  60                  

Ile Tyr Gly Phe Ser Leu Ile Pro Lys Gly Met Asp His Leu Phe Phe 
65                  70                  75                  80  

Asp Asn Leu Trp Ala Leu Gly Gln Arg Leu Val Arg Lys Gly Glu Phe 
                85                  90                  95      

Asp Lys Tyr Leu Thr Arg Pro Ile Asn Pro Leu Phe His Ile Leu Val 
            100                 105                 110         

Glu Thr Phe Gln Ile Asp Ala Leu Gly Glu Leu Leu Val Gly Gly Ile 
        115                 120                 125             

Leu Leu Gly Thr Thr Val Thr Ser Ile Val Trp Thr Leu Pro Lys Phe 
    130                 135                 140                 

Leu Leu Phe Leu Val Cys Ile Pro Phe Ala Thr Leu Ile Tyr Thr Ser 
145                 150                 155                 160 

Leu Lys Ile Ala Thr Ala Ser Ile Ala Phe Trp Thr Lys Gln Ser Gly 
                165                 170                 175     

Ala Met Ile Tyr Ile Phe Tyr Met Phe Asn Asp Phe Ala Lys Tyr Pro 
            180                 185                 190         


Ile Ser Ile Tyr Asn Ser Leu Leu Arg Trp Leu Ile Ser Phe Ile Val 
        195                 200                 205             

Pro Phe Ala Phe Thr Ala Tyr Tyr Pro Ala Ser Tyr Phe Leu Gln Glu 
    210                 215                 220                 

Lys Asp Val Phe Phe Asn Val Gly Gly Leu Met Leu Ile Ser Leu Val 
225                 230                 235                 240 

Phe Phe Val Ile Ser Leu Lys Leu Trp Asp Lys Gly Leu Asp Ser Tyr 
                245                 250                 255     

Glu Ser Ala Gly Ser 
            260     

<210>   1173
<211>   279
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1173
atgatgtttg taattgaaga agtcaaggat gaaaatcaaa aaaaggcagt tgtcgctgag   60
gttttgaagg atttgccaga atggtttgga atcccagaaa gcacacaagc ctatatagaa   120
ggaaccacga cactgcaagt ttggaccgcc tatcaggaga gtgatttgac tagatttgta   180
agcttatcct attcgagtga agattgtgca gagattgatt gtctcggcgt aaaaaagctt   240
atcaaggtag aaaaattggg agccaattgc ttgctactt                          279

<210>   1174
<211>   93
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1174
Met Met Phe Val Ile Glu Glu Val Lys Asp Glu Asn Gln Lys Lys Ala 
1               5                   10                  15      

Val Val Ala Glu Val Leu Lys Asp Leu Pro Glu Trp Phe Gly Ile Pro 
            20                  25                  30          

Glu Ser Thr Gln Ala Tyr Ile Glu Gly Thr Thr Thr Leu Gln Val Trp 
        35                  40                  45              

Thr Ala Tyr Gln Glu Ser Asp Leu Thr Arg Phe Val Ser Leu Ser Tyr 
    50                  55                  60                  

Ser Ser Glu Asp Cys Ala Glu Ile Asp Cys Leu Gly Val Lys Lys Leu 
65                  70                  75                  80  

Ile Lys Val Glu Lys Leu Gly Ala Asn Cys Leu Leu Leu 
                85                  90              

<210>   1175
<211>   243
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1175
ttgtctcggc gtaaaaaagc ttatcaaggt agaaaaattg ggagccaatt gcttgctact   60
ttagagagtg aagctcgtaa aaaagttggt tatctgcagg tcaaaacagt ggcagaaggt   120
tctaataaag attatgatcg aacaaatgac ttttatcgag gtcttggctt taaaaagtta   180
gagatttttc ctcaactatg gaatccgcaa aatccttgtc agattttgat taaaaagctt   240
gaa                                                                 243

<210>   1176
<211>   81
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902604 (6.E-42)

<400>   1176
Met Ser Arg Arg Lys Lys Ala Tyr Gln Gly Arg Lys Ile Gly Ser Gln 
1               5                   10                  15      

Leu Leu Ala Thr Leu Glu Ser Glu Ala Arg Lys Lys Val Gly Tyr Leu 
            20                  25                  30          

Gln Val Lys Thr Val Ala Glu Gly Ser Asn Lys Asp Tyr Asp Arg Thr 
        35                  40                  45              

Asn Asp Phe Tyr Arg Gly Leu Gly Phe Lys Lys Leu Glu Ile Phe Pro 
    50                  55                  60                  

Gln Leu Trp Asn Pro Gln Asn Pro Cys Gln Ile Leu Ile Lys Lys Leu 
65                  70                  75                  80  

Glu 
    

<210>   1177
<211>   222
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1177
atgaaaatca aagagcaaac taggaaacta gccgcagatt gctcaaaaca gtgttttgag   60
gttgtagatg gaactgacgt agtcagctca aaacactgtt ttgaggttgt ggatagaact   120
gacgaagtca gtaaccatac gcacggcaag gcgacgttga cgtggtttga agagattttc   180
gaagagtata agtccaaaac tttcgttaac cgggatacat ta                      222

<210>   1178
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1178
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Asp Cys Ser Lys 
1               5                   10                  15      

Gln Cys Phe Glu Val Val Asp Gly Thr Asp Val Val Ser Ser Lys His 
            20                  25                  30          

Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Asn His Thr His 
        35                  40                  45              

Gly Lys Ala Thr Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr Lys 
    50                  55                  60                  

Ser Lys Thr Phe Val Asn Arg Asp Thr Leu 
65                  70                  

<210>   1179

<211>   6420
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1179
atgaaaaaaa gtacagtatt gtcattaacc acagctgcag ttattttagc agcctatgcc   60
cctaatgagg tagtcttagc agacacatct agctctgaag atgctttaaa catctctgat   120
aaagaaaaag tagcagaaaa taaagagaaa catgaaaata tccatagtgc tatggaaact   180
tcacaggatt ttaaagagaa gaaaacagca gtcattaagg aaaaagaagt tgttagtaaa   240
aatcctgtga tagacaataa cactagcaat gaagaagcaa aaatcaaaga agaaaattcc   300
aataaatccc aaggagatta tacggactca tttgtgaata aaaacacaga aaatcccaaa   360
aaagaagata aagttgtcta tattgctgaa tttaaagata aagaatctgg agaaaaagca   420
atcaaggaac tatccagtct taagaataca aaagttttat atacttatga tagaattttt   480
aacggtagtg ccatagaaac aactccagat aacttggaca aaattaaaca aatagaaggt   540
atttcatcgg ttgaaagggc acaaaaagtc caacccatga tgaatcatgc cagaaaggaa   600
attggagttg aggaagctat tgattaccta aagtctatca atgctccgtt tgggaaaaat   660
tttgatggta gaggtatggt catttcaaat atcgatactg gaacagatta tagacataag   720
gctatgagaa tcgatgatga tgccaaagcc tcaatgagat ttaaaaaaga agacttaaaa   780
ggcactgata aaaattattg gttgagtgat aaaatccctc atgcgttcaa ttattataat   840
ggtggcaaaa tcactgtaga aaaatatgat gatggaaggg attattttga cccacatggg   900
atgcatattg cagggattct tgctggaaat gatactgaac aagacatcaa aaactttaac   960
ggcatagatg gaattgcacc taatgcacaa attttctctt acaaaatgta ttctgacgca   1020
ggatctgggt ttgcgggtga tgaaacaatg tttcatgcta ttgaagattc tatcaaacac   1080
aacgttgatg ttgtttcggt atcatctggt tttacaggaa caggtcttgt aggtgagaaa   1140
tattggcaag ctattcgggc attaagaaaa gcaggcattc caatggttgt cgctacgggt   1200
aactatgcga cttctgcttc aagttcttca tgggatttag tagcaaataa tcatctgaaa   1260
atgaccgaca ctggaaatgt aacacgaact gcagcacatg aagatgcgat agcggtcgct   1320
tctgctaaaa atcaaacagt tgagtttgat aaagttaaca taggtggaga aagttttaaa   1380
tacagaaata taggggcctt tttcgataag agtaaaatca caacaaatga agatggaaca   1440
aaagctccta gtaaattaaa atttgtatat ataggcaagg ggcaagacca agatttgata   1500
ggtttggatc ttaggggcaa aattgcagta atggatagaa tttatacaaa ggatttaaaa   1560
aatgctttta aaaaagctat ggataagggt gcacgcgcca ttatggttgt aaatactgta   1620
aattactaca atagagataa ttggacagag cttccagcta tgggatatga agcggatgaa   1680
ggtactaaaa gtcaagtgtt ttcaatttca ggagatgatg gtgtaaagct atggaacatg   1740
attaatcctg ataaaaaaac tgaagtcaaa agaaataata aagaagattt taaagataaa   1800
ttggagcaat actatccaat tgatatggaa agttttaatt ccaacaaacc gaatgtaggt   1860
gacgaaaaag agattgactt taagtttgca cctgacacag acaaagaact ctataaagaa   1920
gatatcatcg ttccagcagg atctacatct tgggggccaa gaatagattt acttttaaaa   1980
cccgatgttt cagcacctgg taaaaatatt aaatccacgc ttaatgttat taatggcaaa   2040
tcaacttatg gctatatgtc aggaactagt atggcgactc caatcgtggc agcttctact   2100
gttttgatta gaccgaaatt aaaggaaatg cttgaaagac ctgtattgaa aaatcttaag   2160
ggagatgaca aaatagatct tacaagtctt acaaaaattg ccctacaaaa tactgcgcga   2220
cctatgatgg atgcaacttc ttggaaagaa aaaagtcaat actttgcatc acctagacaa   2280
cagggagcag gcctaattaa tgtggccaat gctttgagaa atgaagttgt agcaactttc   2340
aaaaacactg attctaaagg tttggtaaac tcatatggtt ccatttctct taaagaaata   2400
aaaggtgata aaaaatactt tacaatcaag cttcacaata catcaaacag acctttgact   2460
tttaaagttt cagcatcagc gataactaca gattctctaa ctgacagatt aaaacttgat   2520
gaaacatata aagatgaaaa atctccagat ggtaagcaaa ttgttccaga aattcaccca   2580
gaaaaagtca aaggagcaaa tatcacattt gagcatgata ctttcactat aggcgcaaat   2640
tctagctttg atttgaatgc ggttataaat gttggagagg ccaaaaacaa aaataaattt   2700
gtagaatcat ttattcattt tgagtcagtg gaagaaatgg aagctctaaa ctccaacggg   2760
aagaaaataa acttccaacc ttctttgtcg atgcctctaa tgggatttgc tgggaattgg   2820
aaccacgaac caatccttga taaatgggct tgggaagaag ggtcaagatc aaaaacactg   2880
ggaggttatg atgatgatgg taaaccgaaa attccaggaa ccttaaataa gggaattggt   2940
ggagaacatg gtatagataa atttaatcca gcaggagtta tacaaaatag aaaagataaa   3000
aatacaacat ccctggatca aaatccagaa ttatttgctt tcaataacga agggatcaac   3060
gctccatcat caagtggttc taagattgct aacatttatc ctttagattc aaatggaaat   3120
cctcaagatg ctcaacttga aagaggatta acaccttctc cacttgtatt aagaagtgca   3180
gaagaaggat tgatttcaat agtaaataca aataaagagg gagaaaatca aagagactta   3240
aaagtcattt cgagagaaca ctttattaga ggaattttaa attctaaaag caatgatgca   3300
aagggaatca aatcatctaa actaaaagtt tggggtgact tgaagtggga tggactcatc   3360
tataatccta gaggtagaga agaaaatgca ccagaaagta aggataatca agatcctgct   3420
actaagataa gaggtcaatt tgaaccgatt gcggaaggtc aatatttcta taaatttaaa   3480

tatagattaa ctaaagatta cccatggcag gtttcctata ttcctgtaaa aattgataac   3540
accgccccta agattgtttc ggttgatttt tcaaatcctg aaaaaattaa gttgattaca   3600
aaggatactt atcataaggt aaaagatcag tataagaatg aaacgctatt tgcgagagat   3660
caaaaagaac atcctgaaaa atttgacgag attgcgaacg aagtttggta tgctggcgcc   3720
gctcttgtta atgaagatgg agaggttgaa aaaaatcttg aagtaactta cgcaggtgag   3780
ggtcaaggaa gaaatagaaa acttgataaa gacggaaata ccatttatga aattaaaggt   3840
gcgggagatt taaggggaaa aatcattgaa gtcattgcat tagatggttc tagcaatttc   3900
acaaagattc atagaattaa atttgctaat caggctgatg aaaaggggat gatttcctat   3960
tatctagtag atcctgatca agattcatct aaatatcaaa agcttggcga gattgcagaa   4020
tctaaattta aaaatttagg aaatggaaaa gagggtagtc taaaaaaaga tacaactggg   4080
gtagaacatc atcatcaaga aaatgaagag tctattaaag aaaaatctag ttttactatt   4140
gatagaaata tttcaacaat tagagacttt gaaaataaag acttaaagaa actcattaaa   4200
aagaaattta gagaagttga tgattttaca agtgaaactg gtaagagaat ggaggaatac   4260
gattataaat acgatgataa aggaaatata atagcctacg atgatgggac tgatctagaa   4320
tatgaaactg agaaacttga cgaaatcaaa tcaaaaattt atggtgttct aagtccgtct   4380
aaagatggac actttgaaat tcttggaaag ataagtaatg tttctaaaaa tgccaaggta   4440
tattatggga ataactataa atctatagaa atcaaagcga ccaagtatga tttccactca   4500
aaaacgatga catttgatct atacgctaat attaatgata ttgtggatgg attagctttt   4560
gcaggagata tgagattatt tgttaaagat aatgatcaga aaaaagctga aattaaaatt   4620
agaatgcctg aaaaaattaa ggaaactaaa tcagaatatc cctatgtatc aagttatggg   4680
aatgtcatag aattagggga aggagatctt tcaaaaaaca aaccagacaa tttaactaaa   4740
atggaatctg gtaaaatcta ttctgattca gaaaaacaac aatatctgtt aaaggataat   4800
atcattctaa gaaaaggcta tgcactaaaa gtgactacct ataatcctgg aaaaacggat   4860
atgttagaag gaaatggagt ctatagcaag gaagatatag caaaaataca aaaggccaat   4920
cctaatctaa gagccctttc agaaacaaca atttatgctg atagtagaaa tgttgaagat   4980
ggaagaagta cccaatctgt attaatgtcg gctttggacg gctttaacat tataaggtat   5040
caagtgttta catttaaaat gaacgataaa ggggaagcta tcgataaaga cggaaatctt   5100
gtgacagatt cttctaaact tgtattattt ggtaaggatg ataaagaata cactggagag   5160
gataagttca atgtagaagc tataaaagaa gatggctcca tgttatttat tgataccaaa   5220
ccagtaaacc tttcaatgga taagaactac tttaatccat ctaaatctaa taaaatttat   5280
gtacgaaatc cagaatttta tttaagaggt aagatttctg ataagggtgg ttttaactgg   5340
gaattgagag ttaatgaatc ggttgtagat aattatttaa tctacggaga tttacacatt   5400
gataacacta gagattttaa tattaagctg aatgttaaag acggtgacat catggactgg   5460
ggaatgaaag actataaagc aaacggattt ccagataagg taacagatat ggatggaaat   5520
gtttatcttc aaactggcta tagcgatttg aatgctaaag cagttggagt ccactatcag   5580
tttttatatg ataatgttaa acccgaagta aacattgatc ctaagggaaa tactagtatc   5640
gaatatgctg atggaaaatc tgtagtcttt aacatcaatg ataaaagaaa taatggattc   5700
gatggtgaga ttcaagaaca acatatttat ataaatggaa aagaatatac atcatttaat   5760
gatattaaac aaataataga caagacacta aacattaaga ttgttgtaaa agattttgca   5820
agaaatacaa ccgtaaaaga attcatttta aataaagata cgggagaggt aagtgaatta   5880
aaacctcata gggtaactgt gaccattcaa aatggaaaag aaatgagttc aacgatagtg   5940
tcggaagaag attttatttt acctgtttat aagggtgaat tagaaaaagg ataccaattt   6000
gatggttggg aaatttctgg tttcgaaggt aaaaaagacg ctggctatgt tattaatcta   6060
tcaaaagata cctttataaa acctgtattc aagaaaatag aggagaaaaa ggaggaagaa   6120
aataaaccta cttttgatgt atcgaaaaag aaagataacc cacaagtaaa ccatagtcaa   6180
ttaaatgaaa gtcacagaaa agaggattta caaagagaag agcattcaca aaaatctgat   6240
tcaactaagg atgttacagc tacagttctt gataaaaaca atatcagtag taaatcaact   6300
actaacaatc ctaataagtt gccaaaaact ggaacagcaa gcggagccca gacactatta   6360
gctgccggaa taatgtttat agtaggaatt tttcttggat tgaagaaaaa aaatcaagat   6420

<210>   1180
<211>   2140
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   serine protease, subtilase family
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15902605 (0.E+01)

<400>   1180
Met Lys Lys Ser Thr Val Leu Ser Leu Thr Thr Ala Ala Val Ile Leu 
1               5                   10                  15      

Ala Ala Tyr Ala Pro Asn Glu Val Val Leu Ala Asp Thr Ser Ser Ser 
            20                  25                  30          

Glu Asp Ala Leu Asn Ile Ser Asp Lys Glu Lys Val Ala Glu Asn Lys 
        35                  40                  45              

Glu Lys His Glu Asn Ile His Ser Ala Met Glu Thr Ser Gln Asp Phe 
    50                  55                  60                  

Lys Glu Lys Lys Thr Ala Val Ile Lys Glu Lys Glu Val Val Ser Lys 
65                  70                  75                  80  

Asn Pro Val Ile Asp Asn Asn Thr Ser Asn Glu Glu Ala Lys Ile Lys 
                85                  90                  95      

Glu Glu Asn Ser Asn Lys Ser Gln Gly Asp Tyr Thr Asp Ser Phe Val 
            100                 105                 110         

Asn Lys Asn Thr Glu Asn Pro Lys Lys Glu Asp Lys Val Val Tyr Ile 
        115                 120                 125             

Ala Glu Phe Lys Asp Lys Glu Ser Gly Glu Lys Ala Ile Lys Glu Leu 
    130                 135                 140                 

Ser Ser Leu Lys Asn Thr Lys Val Leu Tyr Thr Tyr Asp Arg Ile Phe 
145                 150                 155                 160 

Asn Gly Ser Ala Ile Glu Thr Thr Pro Asp Asn Leu Asp Lys Ile Lys 
                165                 170                 175     

Gln Ile Glu Gly Ile Ser Ser Val Glu Arg Ala Gln Lys Val Gln Pro 
            180                 185                 190         

Met Met Asn His Ala Arg Lys Glu Ile Gly Val Glu Glu Ala Ile Asp 
        195                 200                 205             

Tyr Leu Lys Ser Ile Asn Ala Pro Phe Gly Lys Asn Phe Asp Gly Arg 
    210                 215                 220                 

Gly Met Val Ile Ser Asn Ile Asp Thr Gly Thr Asp Tyr Arg His Lys 
225                 230                 235                 240 

Ala Met Arg Ile Asp Asp Asp Ala Lys Ala Ser Met Arg Phe Lys Lys 
                245                 250                 255     

Glu Asp Leu Lys Gly Thr Asp Lys Asn Tyr Trp Leu Ser Asp Lys Ile 
            260                 265                 270         

Pro His Ala Phe Asn Tyr Tyr Asn Gly Gly Lys Ile Thr Val Glu Lys 
        275                 280                 285             

Tyr Asp Asp Gly Arg Asp Tyr Phe Asp Pro His Gly Met His Ile Ala 
    290                 295                 300                 

Gly Ile Leu Ala Gly Asn Asp Thr Glu Gln Asp Ile Lys Asn Phe Asn 
305                 310                 315                 320 

Gly Ile Asp Gly Ile Ala Pro Asn Ala Gln Ile Phe Ser Tyr Lys Met 
                325                 330                 335     

Tyr Ser Asp Ala Gly Ser Gly Phe Ala Gly Asp Glu Thr Met Phe His 
            340                 345                 350         

Ala Ile Glu Asp Ser Ile Lys His Asn Val Asp Val Val Ser Val Ser 
        355                 360                 365             

Ser Gly Phe Thr Gly Thr Gly Leu Val Gly Glu Lys Tyr Trp Gln Ala 
    370                 375                 380                 

Ile Arg Ala Leu Arg Lys Ala Gly Ile Pro Met Val Val Ala Thr Gly 
385                 390                 395                 400 

Asn Tyr Ala Thr Ser Ala Ser Ser Ser Ser Trp Asp Leu Val Ala Asn 
                405                 410                 415     

Asn His Leu Lys Met Thr Asp Thr Gly Asn Val Thr Arg Thr Ala Ala 
            420                 425                 430         

His Glu Asp Ala Ile Ala Val Ala Ser Ala Lys Asn Gln Thr Val Glu 
        435                 440                 445             

Phe Asp Lys Val Asn Ile Gly Gly Glu Ser Phe Lys Tyr Arg Asn Ile 
    450                 455                 460                 

Gly Ala Phe Phe Asp Lys Ser Lys Ile Thr Thr Asn Glu Asp Gly Thr 
465                 470                 475                 480 

Lys Ala Pro Ser Lys Leu Lys Phe Val Tyr Ile Gly Lys Gly Gln Asp 
                485                 490                 495     

Gln Asp Leu Ile Gly Leu Asp Leu Arg Gly Lys Ile Ala Val Met Asp 
            500                 505                 510         

Arg Ile Tyr Thr Lys Asp Leu Lys Asn Ala Phe Lys Lys Ala Met Asp 
        515                 520                 525             

Lys Gly Ala Arg Ala Ile Met Val Val Asn Thr Val Asn Tyr Tyr Asn 
    530                 535                 540                 

Arg Asp Asn Trp Thr Glu Leu Pro Ala Met Gly Tyr Glu Ala Asp Glu 
545                 550                 555                 560 

Gly Thr Lys Ser Gln Val Phe Ser Ile Ser Gly Asp Asp Gly Val Lys 
                565                 570                 575     

Leu Trp Asn Met Ile Asn Pro Asp Lys Lys Thr Glu Val Lys Arg Asn 
            580                 585                 590         

Asn Lys Glu Asp Phe Lys Asp Lys Leu Glu Gln Tyr Tyr Pro Ile Asp 
        595                 600                 605             

Met Glu Ser Phe Asn Ser Asn Lys Pro Asn Val Gly Asp Glu Lys Glu 
    610                 615                 620                 

Ile Asp Phe Lys Phe Ala Pro Asp Thr Asp Lys Glu Leu Tyr Lys Glu 
625                 630                 635                 640 

Asp Ile Ile Val Pro Ala Gly Ser Thr Ser Trp Gly Pro Arg Ile Asp 
                645                 650                 655     

Leu Leu Leu Lys Pro Asp Val Ser Ala Pro Gly Lys Asn Ile Lys Ser 
            660                 665                 670         

Thr Leu Asn Val Ile Asn Gly Lys Ser Thr Tyr Gly Tyr Met Ser Gly 
        675                 680                 685             

Thr Ser Met Ala Thr Pro Ile Val Ala Ala Ser Thr Val Leu Ile Arg 
    690                 695                 700                 

Pro Lys Leu Lys Glu Met Leu Glu Arg Pro Val Leu Lys Asn Leu Lys 
705                 710                 715                 720 

Gly Asp Asp Lys Ile Asp Leu Thr Ser Leu Thr Lys Ile Ala Leu Gln 
                725                 730                 735     

Asn Thr Ala Arg Pro Met Met Asp Ala Thr Ser Trp Lys Glu Lys Ser 
            740                 745                 750         

Gln Tyr Phe Ala Ser Pro Arg Gln Gln Gly Ala Gly Leu Ile Asn Val 
        755                 760                 765             

Ala Asn Ala Leu Arg Asn Glu Val Val Ala Thr Phe Lys Asn Thr Asp 
    770                 775                 780                 

Ser Lys Gly Leu Val Asn Ser Tyr Gly Ser Ile Ser Leu Lys Glu Ile 
785                 790                 795                 800 

Lys Gly Asp Lys Lys Tyr Phe Thr Ile Lys Leu His Asn Thr Ser Asn 
                805                 810                 815     

Arg Pro Leu Thr Phe Lys Val Ser Ala Ser Ala Ile Thr Thr Asp Ser 
            820                 825                 830         

Leu Thr Asp Arg Leu Lys Leu Asp Glu Thr Tyr Lys Asp Glu Lys Ser 
        835                 840                 845             

Pro Asp Gly Lys Gln Ile Val Pro Glu Ile His Pro Glu Lys Val Lys 
    850                 855                 860                 

Gly Ala Asn Ile Thr Phe Glu His Asp Thr Phe Thr Ile Gly Ala Asn 
865                 870                 875                 880 

Ser Ser Phe Asp Leu Asn Ala Val Ile Asn Val Gly Glu Ala Lys Asn 
                885                 890                 895     

Lys Asn Lys Phe Val Glu Ser Phe Ile His Phe Glu Ser Val Glu Glu 
            900                 905                 910         

Met Glu Ala Leu Asn Ser Asn Gly Lys Lys Ile Asn Phe Gln Pro Ser 
        915                 920                 925             

Leu Ser Met Pro Leu Met Gly Phe Ala Gly Asn Trp Asn His Glu Pro 
    930                 935                 940                 

Ile Leu Asp Lys Trp Ala Trp Glu Glu Gly Ser Arg Ser Lys Thr Leu 
945                 950                 955                 960 

Gly Gly Tyr Asp Asp Asp Gly Lys Pro Lys Ile Pro Gly Thr Leu Asn 
                965                 970                 975     

Lys Gly Ile Gly Gly Glu His Gly Ile Asp Lys Phe Asn Pro Ala Gly 
            980                 985                 990         

Val Ile Gln Asn Arg Lys Asp Lys Asn Thr Thr Ser Leu Asp Gln Asn 
        995                 1000                1005            

Pro Glu Leu Phe Ala Phe Asn Asn Glu Gly Ile Asn Ala Pro Ser Ser 
    1010                1015                1020                

Ser Gly Ser Lys Ile Ala Asn Ile Tyr Pro Leu Asp Ser Asn Gly Asn 
1025                1030                1035                1040

Pro Gln Asp Ala Gln Leu Glu Arg Gly Leu Thr Pro Ser Pro Leu Val 
                1045                1050                1055    

Leu Arg Ser Ala Glu Glu Gly Leu Ile Ser Ile Val Asn Thr Asn Lys 
            1060                1065                1070        

Glu Gly Glu Asn Gln Arg Asp Leu Lys Val Ile Ser Arg Glu His Phe 
        1075                1080                1085            

Ile Arg Gly Ile Leu Asn Ser Lys Ser Asn Asp Ala Lys Gly Ile Lys 
    1090                1095                1100                

Ser Ser Lys Leu Lys Val Trp Gly Asp Leu Lys Trp Asp Gly Leu Ile 
1105                1110                1115                1120

Tyr Asn Pro Arg Gly Arg Glu Glu Asn Ala Pro Glu Ser Lys Asp Asn 
                1125                1130                1135    

Gln Asp Pro Ala Thr Lys Ile Arg Gly Gln Phe Glu Pro Ile Ala Glu 
            1140                1145                1150        

Gly Gln Tyr Phe Tyr Lys Phe Lys Tyr Arg Leu Thr Lys Asp Tyr Pro 
        1155                1160                1165            

Trp Gln Val Ser Tyr Ile Pro Val Lys Ile Asp Asn Thr Ala Pro Lys 
    1170                1175                1180                

Ile Val Ser Val Asp Phe Ser Asn Pro Glu Lys Ile Lys Leu Ile Thr 
1185                1190                1195                1200

Lys Asp Thr Tyr His Lys Val Lys Asp Gln Tyr Lys Asn Glu Thr Leu 
                1205                1210                1215    

Phe Ala Arg Asp Gln Lys Glu His Pro Glu Lys Phe Asp Glu Ile Ala 
            1220                1225                1230        

Asn Glu Val Trp Tyr Ala Gly Ala Ala Leu Val Asn Glu Asp Gly Glu 
        1235                1240                1245            

Val Glu Lys Asn Leu Glu Val Thr Tyr Ala Gly Glu Gly Gln Gly Arg 
    1250                1255                1260                

Asn Arg Lys Leu Asp Lys Asp Gly Asn Thr Ile Tyr Glu Ile Lys Gly 
1265                1270                1275                1280

Ala Gly Asp Leu Arg Gly Lys Ile Ile Glu Val Ile Ala Leu Asp Gly 
                1285                1290                1295    

Ser Ser Asn Phe Thr Lys Ile His Arg Ile Lys Phe Ala Asn Gln Ala 
            1300                1305                1310        

Asp Glu Lys Gly Met Ile Ser Tyr Tyr Leu Val Asp Pro Asp Gln Asp 
        1315                1320                1325            

Ser Ser Lys Tyr Gln Lys Leu Gly Glu Ile Ala Glu Ser Lys Phe Lys 
    1330                1335                1340                

Asn Leu Gly Asn Gly Lys Glu Gly Ser Leu Lys Lys Asp Thr Thr Gly 
1345                1350                1355                1360

Val Glu His His His Gln Glu Asn Glu Glu Ser Ile Lys Glu Lys Ser 
                1365                1370                1375    

Ser Phe Thr Ile Asp Arg Asn Ile Ser Thr Ile Arg Asp Phe Glu Asn 
            1380                1385                1390        

Lys Asp Leu Lys Lys Leu Ile Lys Lys Lys Phe Arg Glu Val Asp Asp 
        1395                1400                1405            

Phe Thr Ser Glu Thr Gly Lys Arg Met Glu Glu Tyr Asp Tyr Lys Tyr 
    1410                1415                1420                

Asp Asp Lys Gly Asn Ile Ile Ala Tyr Asp Asp Gly Thr Asp Leu Glu 
1425                1430                1435                1440

Tyr Glu Thr Glu Lys Leu Asp Glu Ile Lys Ser Lys Ile Tyr Gly Val 
                1445                1450                1455    

Leu Ser Pro Ser Lys Asp Gly His Phe Glu Ile Leu Gly Lys Ile Ser 
            1460                1465                1470        

Asn Val Ser Lys Asn Ala Lys Val Tyr Tyr Gly Asn Asn Tyr Lys Ser 
        1475                1480                1485            

Ile Glu Ile Lys Ala Thr Lys Tyr Asp Phe His Ser Lys Thr Met Thr 
    1490                1495                1500                

Phe Asp Leu Tyr Ala Asn Ile Asn Asp Ile Val Asp Gly Leu Ala Phe 
1505                1510                1515                1520

Ala Gly Asp Met Arg Leu Phe Val Lys Asp Asn Asp Gln Lys Lys Ala 
                1525                1530                1535    

Glu Ile Lys Ile Arg Met Pro Glu Lys Ile Lys Glu Thr Lys Ser Glu 
            1540                1545                1550        

Tyr Pro Tyr Val Ser Ser Tyr Gly Asn Val Ile Glu Leu Gly Glu Gly 
        1555                1560                1565            

Asp Leu Ser Lys Asn Lys Pro Asp Asn Leu Thr Lys Met Glu Ser Gly 
    1570                1575                1580                

Lys Ile Tyr Ser Asp Ser Glu Lys Gln Gln Tyr Leu Leu Lys Asp Asn 
1585                1590                1595                1600

Ile Ile Leu Arg Lys Gly Tyr Ala Leu Lys Val Thr Thr Tyr Asn Pro 
                1605                1610                1615    

Gly Lys Thr Asp Met Leu Glu Gly Asn Gly Val Tyr Ser Lys Glu Asp 
            1620                1625                1630        

Ile Ala Lys Ile Gln Lys Ala Asn Pro Asn Leu Arg Ala Leu Ser Glu 
        1635                1640                1645            

Thr Thr Ile Tyr Ala Asp Ser Arg Asn Val Glu Asp Gly Arg Ser Thr 
    1650                1655                1660                

Gln Ser Val Leu Met Ser Ala Leu Asp Gly Phe Asn Ile Ile Arg Tyr 
1665                1670                1675                1680

Gln Val Phe Thr Phe Lys Met Asn Asp Lys Gly Glu Ala Ile Asp Lys 
                1685                1690                1695    

Asp Gly Asn Leu Val Thr Asp Ser Ser Lys Leu Val Leu Phe Gly Lys 
            1700                1705                1710        

Asp Asp Lys Glu Tyr Thr Gly Glu Asp Lys Phe Asn Val Glu Ala Ile 
        1715                1720                1725            

Lys Glu Asp Gly Ser Met Leu Phe Ile Asp Thr Lys Pro Val Asn Leu 
    1730                1735                1740                

Ser Met Asp Lys Asn Tyr Phe Asn Pro Ser Lys Ser Asn Lys Ile Tyr 
1745                1750                1755                1760

Val Arg Asn Pro Glu Phe Tyr Leu Arg Gly Lys Ile Ser Asp Lys Gly 
                1765                1770                1775    

Gly Phe Asn Trp Glu Leu Arg Val Asn Glu Ser Val Val Asp Asn Tyr 
            1780                1785                1790        

Leu Ile Tyr Gly Asp Leu His Ile Asp Asn Thr Arg Asp Phe Asn Ile 
        1795                1800                1805            

Lys Leu Asn Val Lys Asp Gly Asp Ile Met Asp Trp Gly Met Lys Asp 
    1810                1815                1820                

Tyr Lys Ala Asn Gly Phe Pro Asp Lys Val Thr Asp Met Asp Gly Asn 
1825                1830                1835                1840

Val Tyr Leu Gln Thr Gly Tyr Ser Asp Leu Asn Ala Lys Ala Val Gly 
                1845                1850                1855    

Val His Tyr Gln Phe Leu Tyr Asp Asn Val Lys Pro Glu Val Asn Ile 
            1860                1865                1870        

Asp Pro Lys Gly Asn Thr Ser Ile Glu Tyr Ala Asp Gly Lys Ser Val 
        1875                1880                1885            

Val Phe Asn Ile Asn Asp Lys Arg Asn Asn Gly Phe Asp Gly Glu Ile 
    1890                1895                1900                

Gln Glu Gln His Ile Tyr Ile Asn Gly Lys Glu Tyr Thr Ser Phe Asn 
1905                1910                1915                1920

Asp Ile Lys Gln Ile Ile Asp Lys Thr Leu Asn Ile Lys Ile Val Val 
                1925                1930                1935    

Lys Asp Phe Ala Arg Asn Thr Thr Val Lys Glu Phe Ile Leu Asn Lys 
            1940                1945                1950        

Asp Thr Gly Glu Val Ser Glu Leu Lys Pro His Arg Val Thr Val Thr 
        1955                1960                1965            

Ile Gln Asn Gly Lys Glu Met Ser Ser Thr Ile Val Ser Glu Glu Asp 
    1970                1975                1980                

Phe Ile Leu Pro Val Tyr Lys Gly Glu Leu Glu Lys Gly Tyr Gln Phe 
1985                1990                1995                2000

Asp Gly Trp Glu Ile Ser Gly Phe Glu Gly Lys Lys Asp Ala Gly Tyr 
                2005                2010                2015    

Val Ile Asn Leu Ser Lys Asp Thr Phe Ile Lys Pro Val Phe Lys Lys 
            2020                2025                2030        

Ile Glu Glu Lys Lys Glu Glu Glu Asn Lys Pro Thr Phe Asp Val Ser 
        2035                2040                2045            

Lys Lys Lys Asp Asn Pro Gln Val Asn His Ser Gln Leu Asn Glu Ser 
    2050                2055                2060                

His Arg Lys Glu Asp Leu Gln Arg Glu Glu His Ser Gln Lys Ser Asp 
2065                2070                2075                2080

Ser Thr Lys Asp Val Thr Ala Thr Val Leu Asp Lys Asn Asn Ile Ser 
                2085                2090                2095    

Ser Lys Ser Thr Thr Asn Asn Pro Asn Lys Leu Pro Lys Thr Gly Thr 
            2100                2105                2110        

Ala Ser Gly Ala Gln Thr Leu Leu Ala Ala Gly Ile Met Phe Ile Val 
        2115                2120                2125            

Gly Ile Phe Leu Gly Leu Lys Lys Lys Asn Gln Asp 
    2130                2135                2140

<210>   1181
<211>   332
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1181
ttgagctatt cagaagactt gaaacaccac tataatctct atcaactctt gctttttcac   60
tttcagaata aggagcctga caaatttttc ggactcattg aggacaatct gaatcaagtt   120
catcctctaa aaccttcctc aaagataaag agaagattgt caatgccctt caactacact   180
attctaatgc caaactggaa gcgaccaata atctcatcaa acttatcaag cgcaatgcct   240
ttggttttcg aaactttgaa aacttcaaaa aacggatttt tatcgctctg aatatcaaaa   300
aagaaaggac aaaatttgtc ctttctcgag ct                                 332

<210>   1182
<211>   96
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase, truncation FRAMESHIFT

<400>   1182
Met Ser Tyr Ser Glu Asp Leu Lys His His Tyr Asn Leu Tyr Gln Leu 
1               5                   10                  15      

Leu Leu Phe His Phe Gln Asn Lys Glu Pro Asp Lys Phe Phe Gly Leu 
            20                  25                  30          

Ile Glu Asp Asn Leu Asn Gln Val His Pro Leu Lys Pro Ser Ser Lys 
        35                  40                  45              

Ile Lys Arg Arg Leu Ser Met Pro Phe Asn Tyr Thr Ile Leu Met Pro 
    50                  55                  60                  

Asn Trp Lys Arg Pro Ile Ile Ser Ser Asn Leu Ser Ser Ala Met Pro 
65                  70                  75                  80  

Leu Val Phe Glu Thr Leu Lys Thr Ser Lys Asn Gly Phe Leu Ser Leu 
                85                  90                  95      


<210>   1183
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1183
atggacaatg ctatatggca taaatcaagt accttaaaga ttccgactaa tattggtttt   60
gcatttattc ctccatacac accagagatg aaccccattg aacaagtgtg gaaagagatt   120
cgtaaacgtg gatttatagt aaaa                                          144

<210>   1184
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase family protein, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902688 (2.E-23)

<400>   1184
Met Asp Asn Ala Ile Trp His Lys Ser Ser Thr Leu Lys Ile Pro Thr 
1               5                   10                  15      

Asn Ile Gly Phe Ala Phe Ile Pro Pro Tyr Thr Pro Glu Met Asn Pro 
            20                  25                  30          

Ile Glu Gln Val Trp Lys Glu Ile Arg Lys Arg Gly Phe Ile Val Lys 
        35                  40                  45              


<210>   1185
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1185
ttgcgagaga gactattgac tcagccctta cttcatgcgg atgaaacttc ttatcgggtt   60
ctagagagtc atagccatct gacctactat tggacctttt tgtctgggaa agttgagaat   120
caagcaatca cgctgtacca tcatgatcag agtcggagtg gttcggtagt acaagaattc   180
ctaggagatt attctggcta tgttcattgt gatatgttgc ggcag                   225

<210>   1186
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf3, degenerate

<400>   1186
Met Arg Glu Arg Leu Leu Thr Gln Pro Leu Leu His Ala Asp Glu Thr 
1               5                   10                  15      

Ser Tyr Arg Val Leu Glu Ser His Ser His Leu Thr Tyr Tyr Trp Thr 
            20                  25                  30          

Phe Leu Ser Gly Lys Val Glu Asn Gln Ala Ile Thr Leu Tyr His His 
        35                  40                  45              

Asp Gln Ser Arg Ser Gly Ser Val Val Gln Glu Phe Leu Gly Asp Tyr 
    50                  55                  60                  

Ser Gly Tyr Val His Cys Asp Met Leu Arg Gln 
65                  70                  75  

<210>   1187
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1187
ttggtaaact gcgaaccgct agaagcttat cgtcaactgg aagaagctga acttgttgga   60
tgttgggcgc atgtgagaag gaaatttttt gaagcgaccc ccaagcaagc agataaatca   120
tccttaggag ctaaaggttt agcttattgt gatcagttat tttccttgga aatagactgg   180
gaggctttgc cagctgatga acgactacag aaacgtcaag aacatctcca gcccctaatg   240
gaagacttct ttgcttggtg ccgccgtcag tcagttttag caggttcaaa actaggaagg   300
gcaattgaat acagcctcaa gtatgaagaa acctttaaga ctattttgaa agacggacat   360
ctggtccttt ccaataatct agctgaacgc gccattaaat cattggttat gggacggagt   420
aaaagagtcc agtggactct tttagcc                                       447

<210>   1188
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein

<400>   1188
Met Val Asn Cys Glu Pro Leu Glu Ala Tyr Arg Gln Leu Glu Glu Ala 
1               5                   10                  15      

Glu Leu Val Gly Cys Trp Ala His Val Arg Arg Lys Phe Phe Glu Ala 
            20                  25                  30          

Thr Pro Lys Gln Ala Asp Lys Ser Ser Leu Gly Ala Lys Gly Leu Ala 
        35                  40                  45              

Tyr Cys Asp Gln Leu Phe Ser Leu Glu Ile Asp Trp Glu Ala Leu Pro 
    50                  55                  60                  

Ala Asp Glu Arg Leu Gln Lys Arg Gln Glu His Leu Gln Pro Leu Met 
65                  70                  75                  80  

Glu Asp Phe Phe Ala Trp Cys Arg Arg Gln Ser Val Leu Ala Gly Ser 
                85                  90                  95      

Lys Leu Gly Arg Ala Ile Glu Tyr Ser Leu Lys Tyr Glu Glu Thr Phe 
            100                 105                 110         

Lys Thr Ile Leu Lys Asp Gly His Leu Val Leu Ser Asn Asn Leu Ala 
        115                 120                 125             

Glu Arg Ala Ile Lys Ser Leu Val Met Gly Arg Ser Lys Arg Val Gln 
    130                 135                 140                 

Trp Thr Leu Leu Ala 
145                 

<210>   1189
<211>   495
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1189
atggaaagaa gggaaaaact tatggtatta gattatttct ttgacaaaaa ccttgtgttt   60
tgcttagaag cggatagtca agaacaactc tttgatcagg ttgcaacttt attggaagaa   120
cgagaaattg tcactccaac ttatcgtgaa gccttgatca cgcgtgaaaa gtcatttcca   180
actggtttag atatggaatt tctaggaaag gacttgccaa atgtagcgat tcctcacaca   240
gatattgttc ataatctagc tgagaaagtg gtggttgttc gattagaaaa accaataact   300
tttcacaata tgatagctcc tgataaggaa gtagaagtat ccctactctt ctttatcatt   360
aataattcaa gttcaagtca aacgaacatt cttgctcagt taatggactt cttcacagga   420
aatggtcatc ttgaagacct atcaaaaatt tctgaaccag aagcccttta tacttacatt   480
gctgaagcaa ccgct                                                    495

<210>   1190
<211>   165
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system IIA component, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902606 (7.E-86)

<400>   1190
Met Glu Arg Arg Glu Lys Leu Met Val Leu Asp Tyr Phe Phe Asp Lys 
1               5                   10                  15      

Asn Leu Val Phe Cys Leu Glu Ala Asp Ser Gln Glu Gln Leu Phe Asp 
            20                  25                  30          

Gln Val Ala Thr Leu Leu Glu Glu Arg Glu Ile Val Thr Pro Thr Tyr 
        35                  40                  45              

Arg Glu Ala Leu Ile Thr Arg Glu Lys Ser Phe Pro Thr Gly Leu Asp 
    50                  55                  60                  

Met Glu Phe Leu Gly Lys Asp Leu Pro Asn Val Ala Ile Pro His Thr 
65                  70                  75                  80  

Asp Ile Val His Asn Leu Ala Glu Lys Val Val Val Val Arg Leu Glu 
                85                  90                  95      

Lys Pro Ile Thr Phe His Asn Met Ile Ala Pro Asp Lys Glu Val Glu 
            100                 105                 110         

Val Ser Leu Leu Phe Phe Ile Ile Asn Asn Ser Ser Ser Ser Gln Thr 
        115                 120                 125             

Asn Ile Leu Ala Gln Leu Met Asp Phe Phe Thr Gly Asn Gly His Leu 
    130                 135                 140                 

Glu Asp Leu Ser Lys Ile Ser Glu Pro Glu Ala Leu Tyr Thr Tyr Ile 
145                 150                 155                 160 

Ala Glu Ala Thr Ala 
                165 

<210>   1191
<211>   303
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1191
atgattaaaa ttcttgctgc ctgcggtgca ggtgttaact caagtcacca aattaaaagt   60
gctctagaag aagaactttc aaaccgtggt tatgatgttc actgtgatgc agtcatggtg   120
aaagatgtaa acgaagacct tatgaaaggt tacgatatct ttacaccaat cgctgcaaca   180
gaccttggtt ttgaaccagg tatcccagtt atcgaagctg ggccaatctt attccgtatc   240
ccagcaatga gcgctccagt atttgacaat attgaagcag ctattaaaga acacggatta   300
agc                                                                 303

<210>   1192
<211>   101
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIB component, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902607 (1.E-54)

<400>   1192

Met Ile Lys Ile Leu Ala Ala Cys Gly Ala Gly Val Asn Ser Ser His 
1               5                   10                  15      

Gln Ile Lys Ser Ala Leu Glu Glu Glu Leu Ser Asn Arg Gly Tyr Asp 
            20                  25                  30          

Val His Cys Asp Ala Val Met Val Lys Asp Val Asn Glu Asp Leu Met 
        35                  40                  45              

Lys Gly Tyr Asp Ile Phe Thr Pro Ile Ala Ala Thr Asp Leu Gly Phe 
    50                  55                  60                  

Glu Pro Gly Ile Pro Val Ile Glu Ala Gly Pro Ile Leu Phe Arg Ile 
65                  70                  75                  80  

Pro Ala Met Ser Ala Pro Val Phe Asp Asn Ile Glu Ala Ala Ile Lys 
                85                  90                  95      

Glu His Gly Leu Ser 
            100     

<210>   1193
<211>   1473
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1193
atggatgcaa tctttgacct aatcggaaag gttttcaatc ccatcttaga aatgggtgga   60
cctgtcatca tgttaatcat tttgacagta ttggctttac tttttggagt gaaattctcc   120
aaagcgcttg aaggtggtat caaacttgcc atcgctctta caggtatcgg tgctatcatc   180
ggtatgctaa acactgcttt ctcagcatca ctagcaaaat tcgttgaaaa cactggtatc   240
caattgagta ttaccgacgt tggttgggca ccacttgcta caatcacttg gggttctgct   300
tggacactat acttcttgct catcatgttg attgtcaaca tagtgatgct agctatgaag   360
aaaacagata cacttgatgt cgatatcttt gatatctggc acttgtctat cacaggtctc   420
ttgattaaat ggtatgctga taacaatggt gtgagtcaag gggtttcact ctttattgct   480
acagcagcta tcgtccttgt cggtgtgttg aaaattatca actctgactt gatgaaacct   540
acatttgatg accttcttaa cgccccaagt tcatcaccaa tgacatcaac tcacatgaac   600
tacatgatga acccagttat catggttttg gataagattt ttgaaaaatt cttcccaggc   660
cttgataaat atgactttga tgctgctaaa ttgaacaaga aaatcggttt ctggggatct   720
aaattcttca tcggtttcat ccttggtatc gttatcggta ttatgggaac tccacatcca   780
attgcaggtg ttgcagatgc agataaatgg cgtcttgtta tcaaaggatg gttgtctctt   840
ggtttgactg ccggtgtatc tttggaactc ttctcactta tcggttcatg gttcatcgca   900
gccgtagaac cactatcaca aggtattaca aacgttgcta ctaaacgtct tcaaggacgt   960
aaattcaata tcggtcttga ctggccattc atcgctggtc gtgctgaaat ctgggcttgt   1020
gccaacgtac ttgcaccaat catgttgatt gaagcagtgc ttctttcaaa agttggaaat   1080
ggtatcttgc cacttgcagg tatcatcgct atgggtgtta ctccagctct cttggttgta   1140
actcgtggta aattgctccg tatgattatc ttcggaacac tcttgttgcc actcttcctt   1200
ctttcaggta cacttattgc accatttgca acagaacttg ctaaaggtgt aggtgccttc   1260
ccagaaggtg tgagccaaac tcaattgatt actcactcta ctcttgaagg accaatcgaa   1320
aaacttcttg gttggacaat tggtaacact acaactggtg atatcaaagc aatccttggt   1380
gcagtagtct tccttgtatt ctatatcggt atctttgctt ggtacagaaa acaaatgatc   1440
aaacgtaacg aagagtacgc agcaaaagca aaa                                1473

<210>   1194
<211>   491
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIC component, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902608 (0.E+01)

<400>   1194
Met Asp Ala Ile Phe Asp Leu Ile Gly Lys Val Phe Asn Pro Ile Leu 
1               5                   10                  15      

Glu Met Gly Gly Pro Val Ile Met Leu Ile Ile Leu Thr Val Leu Ala 
            20                  25                  30          

Leu Leu Phe Gly Val Lys Phe Ser Lys Ala Leu Glu Gly Gly Ile Lys 
        35                  40                  45              

Leu Ala Ile Ala Leu Thr Gly Ile Gly Ala Ile Ile Gly Met Leu Asn 
    50                  55                  60                  

Thr Ala Phe Ser Ala Ser Leu Ala Lys Phe Val Glu Asn Thr Gly Ile 
65                  70                  75                  80  

Gln Leu Ser Ile Thr Asp Val Gly Trp Ala Pro Leu Ala Thr Ile Thr 
                85                  90                  95      

Trp Gly Ser Ala Trp Thr Leu Tyr Phe Leu Leu Ile Met Leu Ile Val 
            100                 105                 110         

Asn Ile Val Met Leu Ala Met Lys Lys Thr Asp Thr Leu Asp Val Asp 
        115                 120                 125             

Ile Phe Asp Ile Trp His Leu Ser Ile Thr Gly Leu Leu Ile Lys Trp 
    130                 135                 140                 

Tyr Ala Asp Asn Asn Gly Val Ser Gln Gly Val Ser Leu Phe Ile Ala 
145                 150                 155                 160 

Thr Ala Ala Ile Val Leu Val Gly Val Leu Lys Ile Ile Asn Ser Asp 
                165                 170                 175     

Leu Met Lys Pro Thr Phe Asp Asp Leu Leu Asn Ala Pro Ser Ser Ser 
            180                 185                 190         

Pro Met Thr Ser Thr His Met Asn Tyr Met Met Asn Pro Val Ile Met 
        195                 200                 205             

Val Leu Asp Lys Ile Phe Glu Lys Phe Phe Pro Gly Leu Asp Lys Tyr 
    210                 215                 220                 

Asp Phe Asp Ala Ala Lys Leu Asn Lys Lys Ile Gly Phe Trp Gly Ser 
225                 230                 235                 240 

Lys Phe Phe Ile Gly Phe Ile Leu Gly Ile Val Ile Gly Ile Met Gly 
                245                 250                 255     

Thr Pro His Pro Ile Ala Gly Val Ala Asp Ala Asp Lys Trp Arg Leu 
            260                 265                 270         

Val Ile Lys Gly Trp Leu Ser Leu Gly Leu Thr Ala Gly Val Ser Leu 
        275                 280                 285             

Glu Leu Phe Ser Leu Ile Gly Ser Trp Phe Ile Ala Ala Val Glu Pro 
    290                 295                 300                 

Leu Ser Gln Gly Ile Thr Asn Val Ala Thr Lys Arg Leu Gln Gly Arg 
305                 310                 315                 320 

Lys Phe Asn Ile Gly Leu Asp Trp Pro Phe Ile Ala Gly Arg Ala Glu 
                325                 330                 335     

Ile Trp Ala Cys Ala Asn Val Leu Ala Pro Ile Met Leu Ile Glu Ala 
            340                 345                 350         

Val Leu Leu Ser Lys Val Gly Asn Gly Ile Leu Pro Leu Ala Gly Ile 
        355                 360                 365             

Ile Ala Met Gly Val Thr Pro Ala Leu Leu Val Val Thr Arg Gly Lys 
    370                 375                 380                 

Leu Leu Arg Met Ile Ile Phe Gly Thr Leu Leu Leu Pro Leu Phe Leu 
385                 390                 395                 400 

Leu Ser Gly Thr Leu Ile Ala Pro Phe Ala Thr Glu Leu Ala Lys Gly 
                405                 410                 415     

Val Gly Ala Phe Pro Glu Gly Val Ser Gln Thr Gln Leu Ile Thr His 
            420                 425                 430         

Ser Thr Leu Glu Gly Pro Ile Glu Lys Leu Leu Gly Trp Thr Ile Gly 
        435                 440                 445             

Asn Thr Thr Thr Gly Asp Ile Lys Ala Ile Leu Gly Ala Val Val Phe 
    450                 455                 460                 

Leu Val Phe Tyr Ile Gly Ile Phe Ala Trp Tyr Arg Lys Gln Met Ile 
465                 470                 475                 480 

Lys Arg Asn Glu Glu Tyr Ala Ala Lys Ala Lys 
                485                 490     

<210>   1195
<211>   279
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1195
atgaaaatca aagagcaaac taggaagcta gccgcaggtt gctcaaaaca cagttttgag   60
gttgtagata agactgacga agtcagctca aaacatggtt ttgaggttgt agatgaaact   120
gacgaagtca gctcaaaaca tggttttgag gttgtagatg aaactgacga agtcagctca   180
aaacatggtt ttgaggttgt agatgaaact gacgaagtca gtaatcatat ctacggcaag   240
gcgacactga cgaagtttga attggatttt cgcagagtg                          279

<210>   1196
<211>   93
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1196
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Ser Phe Glu Val Val Asp Lys Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Gly Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Ser Lys His Gly 
        35                  40                  45              

Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Ser Lys His Gly Phe 
    50                  55                  60                  

Glu Val Val Asp Glu Thr Asp Glu Val Ser Asn His Ile Tyr Gly Lys 
65                  70                  75                  80  

Ala Thr Leu Thr Lys Phe Glu Leu Asp Phe Arg Arg Val 
                85                  90              

<210>   1197
<211>   6699
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1197
atggggaaag gccattggaa tcggaaaaga gtttatagca ttcgtaagtt tgctgtggga   60
gcttgctcag taatgattgg gacttgtgca gttttattag gaggaaatat agctggagaa   120
tctgtagttt atgcggatga aacacttatt actcatactg ctgagaaacc taaagaggaa   180
aaaatgatag tagaagaaaa ggctgataaa gctttggaaa ctaaaaatat agttgaaagg   240
acagaacaaa gtgaacctag ttcaactgag gctattgcat ctgagaagaa agaagatgaa   300
gccgtaactc caaaagagga aaaagtgtct gctaaaccgg aagaaaaagc tccaaggata   360
gaatcacaag cttcaaatca agaaaaaccg ctcaaggaag atgctaaagc tgtaacaaat   420
gaagaagtga atcaaatgat tgaagacagg aaagtggatt ttaatcaaaa ttggtacttt   480
aaactcaatg caaattctaa ggaagccatt aaacctgatg cagacgtatc tacgtggaaa   540
aaattagatt taccgtatga ctggagtatc tttaacgatt tcgatcatga atctcctgca   600
caaaatgaag gtggacagct caacggtggg gaagcttggt atcgcaagac tttcaaacta   660
gatgaaaaag acctcaagaa aaatgttcgc cttacttttg atggcgtcta catggattct   720
caagtttatg tcaatggtca gttagtgggg cattatccaa atggttataa ccagttctca   780
tatgatatca ccaaatacct tcaaaaagat ggtcgtgaga atgtgattgc tgtccatgca   840
gtcaacaaac agccaagtag ccgttggtat tcaggaagtg gtatctatcg tgatgtgact   900
ttacaagtga cagataaggt gcatgttgag aaaaatggga caactatttt aacaccaaaa   960
cttgaagaac aacaacatgg caaggttgaa actcatgtga ccagcaaaat cgtcaatacg   1020
gacgacaaag accatgaact tgtagccgaa tatcaaatcg ttgaacgagg tggtcatgct   1080
gtaacaggct tagttcgtac agcgagtcgt accttaaaag cacatgaatc aacaagccta   1140
gatgcgattt tagaagttga aagaccaaaa ctctggactg ttttaaatga caaacctgcc   1200
ttgtacgaat tgattacgcg tgtttaccgt gacggtcaat tggttgatgc taagaaggat   1260
ttgtttggtt accgttacta tcactggact ccaaatgaag gtttctcttt gaatggtgaa   1320
cgtattaaat tccatggagt atccttgcac cacgaccatg gggcgcttgg agcagaagaa   1380
aactataaag cagaatatcg ccgtctcaaa caaatgaagg agatgggagt taactccatc   1440
cgtacaaccc acaaccctgc tagtgagcaa accttgcaaa tcgcagcaga actaggttta   1500
ctcgttcagg aagaggcctt tgatacgtgg tatggtggca agaaacctta tgactatgga   1560
cgtttctttg aaaaagatgc cactcaccca gaagctcgaa aaggtgaaaa atggtctgat   1620
tttgacctac gtaccatggt cgaaagaggc aaaaacaacc ctgctatctt catgtggtca   1680
attggtaatg aaataggtga agctaatggt gatgcccact ctttagcaac tgttaaacgt   1740
ttggttaagg ttatcaagga tgttgataag actcgctatg ttaccatggg agcagataaa   1800
ttccgtttcg gtaatggtag cggagggcat gagaaaattg ctgatgaact cgatgctgtt   1860
ggatttaact attctgaaga taattacaaa gcccttagag ctaagcatcc aaaatggttg   1920
atttatggat cagaaacatc ttcagctacc cgtacacgtg gaagttacta tcgccctgaa   1980
cgtgaattga aacatagcaa tggacctgag cgtaattatg aacagtcaga ttatggaaat   2040
gatcgtgtgg gttgggggaa aacagcaacc gcttcatgga cttttgaccg tgacaacgct   2100
ggctatgctg gacagtttat ctggacaggt acggactata ttggtgaacc tacaccatgg   2160
cacaaccaaa atcaaactcc tgttaagagc tcttactttg gtatcgtaga tacagccggc   2220
attccaaaac atgacttcta tctctaccaa agccaatggg tttctgttaa gaagaaaccg   2280
atggtacacc ttcttcctca ctggaactgg gaaaacaaag aattagcatc caaagtagct   2340
gactcagaag gtaagattcc agttcgtgct tattcgaatg cttctagtgt agaattgttc   2400
ttgaatggaa aatctcttgg tcttaagact ttcaataaaa aacaaaccag cgatgggcgg   2460
acttaccaag aaggtgcaaa tgctaatgaa ctttatcttg aatggaaagt tgcctatcaa   2520
ccaggtacct tggaagcaat tgctcgtgat gaatctggca aggaaattgc tcgagataag   2580
attacgactg ctggtaagcc agcggcagtt cgtcttatta aggaagacca tgcgattgca   2640
gcagatggaa aagacttgac ttacatctac tatgaaattg ttgacagcca ggggaatgtg   2700
gttccaactg ctaataatct ggttcgcttc caattgcatg gccaaggtca actggtcggt   2760
gtagataacg gagaacaagc cagccgtgaa cgctataagg cgcaagcaga tggttcttgg   2820
attcgtaaag catttaatgg taaaggtgtt gccattgtca aatcaactga acaagcaggg   2880
aaattcaccc tgactgccca ctctgatctc ttgaaatcga accaagtcac tgtctttact   2940
ggtaagaaag aaggacaaga gaagactgtt ttggggacag aagtgccaaa agtacagacc   3000
attattggag aggcacctga aatgcctacc actgttccgt ttgtatacag tgatggtagc   3060
cgtgcagaac gtcctgtaac ctggtcttca gtagatgtga gcaagcctgg tattgtaacg   3120
gtgaaaggta tggctgacgg acgagaagta gaagctcgtg tagaagtgat tgctcttaaa   3180
tcagagctac cagttgtgaa acgtattgct ccaaatactg acttgaattc tgtagacaaa   3240
tctgtttcct atgttttgat tgatggaagt gttgaagagt atgaagtgga caagtgggag   3300
attgccgaag aagataaagc taagttagca attccaggtt ctcgtattca agcgaccggt   3360
tatttagaag gtcaaccaat tcatgcaacc cttgtggtag aagaaggcaa tcctgcggca   3420
cctgcagtac caactgtaac ggttggtggt gaggcagtaa caggtcttac tagtcaaaaa   3480
ccaatgcaat accgcactct tgcttatgga gctaagttgc cagaagtcac agcaagtgct   3540
aaaaatgcag ctgttacagt tcttcaagca agcgcagcaa acggcatgcg tgcgagcatc   3600
tttattcagc ctaaagatgg tggccctctt caaacctatg caattcaatt ccttgaagaa   3660
gcgccaaaaa ttgctcactt gagcttgcaa gtggaaaaag ctgacagtct caaagaagac   3720
caaactgtca aattgtcggt tcgagctcac tatcaagatg gaacgcaagc tgtattacca   3780
gctgataaag taaccttctc tacaagtggt gaaggggaag tcgcaattcg taaaggaatg   3840
cttgagttgc ataagccagg agcagtcact ctgaacgctg aatatgaggg agctaaagac   3900
caagttgaac tcactatcca agccaatact gagaagaaga ttgcgcaatc catccgtcct   3960
gtaaatgtag tgacagattt gcatcaggaa ccaagtcttc cagcaacagt aacagttgag   4020
tatgacaaag gtttccctaa aactcataaa gtcacttggc aagctattcc gaaagaaaaa   4080
ctagactcct atcaaacatt tgaagtacta ggtaaagttg aaggaattga ccttgaagcg   4140
cgtgcaaaag tctctgtaga aggtatcgtt tcagttgaag aagtcagtgt gacaactcca   4200
atcgcagaag caccacaatt accagaaagt gttcggacat atgattcaaa tggtcacgtt   4260
tcatcagcta aggttgcatg ggatgcgatt cgtccagagc aatacgctaa ggaaggtgtc   4320
tttacagtta atggtcgctt agaaggtacg caattaacaa ctaaacttca tgttcgcgta   4380
tctgctcaaa ctgagcaagg tgcaaacatt tctgaccaat ggaccggttc agaattgcca   4440
cttgcctttg cttcagactc aaatccaagc gacccagttt caaatgttaa tgacaagctc   4500
atttcctaca ataaccaacc agccaatcgt tggacaaact ggaatcgtac taatccagaa   4560
gcttcagtcg gtgttctgtt tggagattca ggtatcttga gcaaacgctc cgttgataat   4620
ctaagtgtcg gattccatga agaccatgga gttggtgtac cgaagtctta tgtgattgag   4680
tattatgttg gtaagactgt cccaacagct cctaaaaacc ctagttttgt tggtaatgag   4740
gaccatgtct ttaatgattc tgccaactgg aaaccagtta ctaatctaaa agcccctgct   4800
caactcaagg ctggagaaat gaaccacttt agctttgata aagttgaaac ctatgctgtt   4860
cgtattcgca tggttaaagc agataacaag cgtggaacgt ctatcacaga ggtacaaatc   4920
tttgcgaaac aagttgcggc agccaagcaa ggacaaacaa gaatccaagt tgacggcaaa   4980
gacttagcaa acttcaaccc tgatttgaca gactactacc ttgagtctgt agatggaaaa   5040
gttccggcag tcacagcaag tgttagcaac aatggtctcg ctaccgtcgt tccaagcgtt   5100
cgtgaaggtg agccagttcg tgtcatcgcg aaagctgaaa atggcgacat cttaggagaa   5160
taccgtctgc acttcactaa ggataagagc ttactttctc ataaaccagt tgctgcggtt   5220
aaacaagctc gcttgctaca agtaggtcaa gcacttgaat tgccgactaa ggttccagtt   5280
tacttcacag gtaaagacgg ctacgaaaca aaagacctga cagttgaatg ggaagaagtt   5340
ccagcggaaa atctgacaaa agcaggtcaa tttactgttc gaggccgtgt ccttggtagt   5400
aaccttgttg ctgagatcac tgtacgagtg acagacaaac ttggtgagac tctttcagat   5460
aaccctaact atgatgaaaa cagtaaccag gcctttgctt cagcaaccaa tgatattgac   5520
aaaaactctc atgaccgcgt tgactatctc aatgacggag atcattcaga aaatcgtcgt   5580
tggacaaact ggtcaccaac accatcttct aatccagaag tatcagcggg tgtgattttc   5640
cgtgaaaatg gtaagattgt agaacggact gttacacaag gaaaagttca gttctttgca   5700
gatagtggta cggatgcacc atctaaactc gttttagaac gctatgtcgg tccagagttt   5760
gaagtgccaa cctactattc aaactaccaa gcctacgacg cagaccatcc attcaacaat   5820
ccagaaaatt gggaagctgt tccttatcgt gcggataaag acattgcagc tggtgatgaa   5880
atcaacgtaa catttaaagc tatcaaagcc aaagctatga gatggcgtat ggagcgtaaa   5940
gcagataaga gcggtgttgc gatgattgag atgaccttcc ttgcaccaag tgaattgcct   6000
caagaaagca ctcaatcaaa gattcttgta gatggaaaag aacttgctga tttcgctgaa   6060
aatcgtcaag actatcaaat tacctataaa ggtcaacggc caaaagtctc agttgaagaa   6120
aacaatcaag tagcttcaac tgtggtagat agtggagaag atagctttcc agtacttgtt   6180
cgcctcgttt cagaaagtgg aaaacaagtc aaggaatacc gtatccactt gactaaggaa   6240
aaaccagttt ctgagaagac agttgctgct gtacaagaag atcttccaaa aatcgaattt   6300
gttgaaaaag atttggcata caagacagtt gagaaaaaag attcaacact gtatctaggt   6360
gaaactcgtg tagaacaaga aggaaaagtt ggaaaagaac gtatctttac agcgattaat   6420
cctgatggaa gtaaggaaga aaaactccgt gaagtggtag aagttccgac agaccgcatc   6480
gtcttggttg gaaccaaacc agtagctcaa gaagctaaaa aaccacaagt gtcagaaaaa   6540
gcagatacaa aaccaattga ttcaagtgaa gctagtcaaa ctaataaagc ccagttacca   6600
agtacaggta gtgcggcaag ccaagcagca gtagcagcag gtttaactct tctaggtttg   6660
agtgcaggat tagtagttac taaaggtaaa aaagaagac                          6699

<210>   1198
<211>   2233
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   beta-galactosidase (bgaA)
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15902609 (0.E+01)

<400>   1198
Met Gly Lys Gly His Trp Asn Arg Lys Arg Val Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ala Val Gly Ala Cys Ser Val Met Ile Gly Thr Cys Ala Val Leu 
            20                  25                  30          

Leu Gly Gly Asn Ile Ala Gly Glu Ser Val Val Tyr Ala Asp Glu Thr 
        35                  40                  45              

Leu Ile Thr His Thr Ala Glu Lys Pro Lys Glu Glu Lys Met Ile Val 
    50                  55                  60                  

Glu Glu Lys Ala Asp Lys Ala Leu Glu Thr Lys Asn Ile Val Glu Arg 
65                  70                  75                  80  

Thr Glu Gln Ser Glu Pro Ser Ser Thr Glu Ala Ile Ala Ser Glu Lys 
                85                  90                  95      

Lys Glu Asp Glu Ala Val Thr Pro Lys Glu Glu Lys Val Ser Ala Lys 
            100                 105                 110         

Pro Glu Glu Lys Ala Pro Arg Ile Glu Ser Gln Ala Ser Asn Gln Glu 
        115                 120                 125             

Lys Pro Leu Lys Glu Asp Ala Lys Ala Val Thr Asn Glu Glu Val Asn 
    130                 135                 140                 

Gln Met Ile Glu Asp Arg Lys Val Asp Phe Asn Gln Asn Trp Tyr Phe 
145                 150                 155                 160 

Lys Leu Asn Ala Asn Ser Lys Glu Ala Ile Lys Pro Asp Ala Asp Val 
                165                 170                 175     

Ser Thr Trp Lys Lys Leu Asp Leu Pro Tyr Asp Trp Ser Ile Phe Asn 
            180                 185                 190         

Asp Phe Asp His Glu Ser Pro Ala Gln Asn Glu Gly Gly Gln Leu Asn 
        195                 200                 205             

Gly Gly Glu Ala Trp Tyr Arg Lys Thr Phe Lys Leu Asp Glu Lys Asp 
    210                 215                 220                 

Leu Lys Lys Asn Val Arg Leu Thr Phe Asp Gly Val Tyr Met Asp Ser 
225                 230                 235                 240 

Gln Val Tyr Val Asn Gly Gln Leu Val Gly His Tyr Pro Asn Gly Tyr 
                245                 250                 255     

Asn Gln Phe Ser Tyr Asp Ile Thr Lys Tyr Leu Gln Lys Asp Gly Arg 
            260                 265                 270         

Glu Asn Val Ile Ala Val His Ala Val Asn Lys Gln Pro Ser Ser Arg 
        275                 280                 285             

Trp Tyr Ser Gly Ser Gly Ile Tyr Arg Asp Val Thr Leu Gln Val Thr 
    290                 295                 300                 

Asp Lys Val His Val Glu Lys Asn Gly Thr Thr Ile Leu Thr Pro Lys 
305                 310                 315                 320 

Leu Glu Glu Gln Gln His Gly Lys Val Glu Thr His Val Thr Ser Lys 
                325                 330                 335     

Ile Val Asn Thr Asp Asp Lys Asp His Glu Leu Val Ala Glu Tyr Gln 
            340                 345                 350         

Ile Val Glu Arg Gly Gly His Ala Val Thr Gly Leu Val Arg Thr Ala 
        355                 360                 365             


Ser Arg Thr Leu Lys Ala His Glu Ser Thr Ser Leu Asp Ala Ile Leu 
    370                 375                 380                 

Glu Val Glu Arg Pro Lys Leu Trp Thr Val Leu Asn Asp Lys Pro Ala 
385                 390                 395                 400 

Leu Tyr Glu Leu Ile Thr Arg Val Tyr Arg Asp Gly Gln Leu Val Asp 
                405                 410                 415     

Ala Lys Lys Asp Leu Phe Gly Tyr Arg Tyr Tyr His Trp Thr Pro Asn 
            420                 425                 430         

Glu Gly Phe Ser Leu Asn Gly Glu Arg Ile Lys Phe His Gly Val Ser 
        435                 440                 445             

Leu His His Asp His Gly Ala Leu Gly Ala Glu Glu Asn Tyr Lys Ala 
    450                 455                 460                 

Glu Tyr Arg Arg Leu Lys Gln Met Lys Glu Met Gly Val Asn Ser Ile 
465                 470                 475                 480 

Arg Thr Thr His Asn Pro Ala Ser Glu Gln Thr Leu Gln Ile Ala Ala 
                485                 490                 495     

Glu Leu Gly Leu Leu Val Gln Glu Glu Ala Phe Asp Thr Trp Tyr Gly 
            500                 505                 510         

Gly Lys Lys Pro Tyr Asp Tyr Gly Arg Phe Phe Glu Lys Asp Ala Thr 
        515                 520                 525             

His Pro Glu Ala Arg Lys Gly Glu Lys Trp Ser Asp Phe Asp Leu Arg 
    530                 535                 540                 

Thr Met Val Glu Arg Gly Lys Asn Asn Pro Ala Ile Phe Met Trp Ser 
545                 550                 555                 560 

Ile Gly Asn Glu Ile Gly Glu Ala Asn Gly Asp Ala His Ser Leu Ala 
                565                 570                 575     

Thr Val Lys Arg Leu Val Lys Val Ile Lys Asp Val Asp Lys Thr Arg 
            580                 585                 590         

Tyr Val Thr Met Gly Ala Asp Lys Phe Arg Phe Gly Asn Gly Ser Gly 
        595                 600                 605             

Gly His Glu Lys Ile Ala Asp Glu Leu Asp Ala Val Gly Phe Asn Tyr 
    610                 615                 620                 

Ser Glu Asp Asn Tyr Lys Ala Leu Arg Ala Lys His Pro Lys Trp Leu 
625                 630                 635                 640 

Ile Tyr Gly Ser Glu Thr Ser Ser Ala Thr Arg Thr Arg Gly Ser Tyr 
                645                 650                 655     

Tyr Arg Pro Glu Arg Glu Leu Lys His Ser Asn Gly Pro Glu Arg Asn 
            660                 665                 670         

Tyr Glu Gln Ser Asp Tyr Gly Asn Asp Arg Val Gly Trp Gly Lys Thr 
        675                 680                 685             

Ala Thr Ala Ser Trp Thr Phe Asp Arg Asp Asn Ala Gly Tyr Ala Gly 
    690                 695                 700                 


Gln Phe Ile Trp Thr Gly Thr Asp Tyr Ile Gly Glu Pro Thr Pro Trp 
705                 710                 715                 720 

His Asn Gln Asn Gln Thr Pro Val Lys Ser Ser Tyr Phe Gly Ile Val 
                725                 730                 735     

Asp Thr Ala Gly Ile Pro Lys His Asp Phe Tyr Leu Tyr Gln Ser Gln 
            740                 745                 750         

Trp Val Ser Val Lys Lys Lys Pro Met Val His Leu Leu Pro His Trp 
        755                 760                 765             

Asn Trp Glu Asn Lys Glu Leu Ala Ser Lys Val Ala Asp Ser Glu Gly 
    770                 775                 780                 

Lys Ile Pro Val Arg Ala Tyr Ser Asn Ala Ser Ser Val Glu Leu Phe 
785                 790                 795                 800 

Leu Asn Gly Lys Ser Leu Gly Leu Lys Thr Phe Asn Lys Lys Gln Thr 
                805                 810                 815     

Ser Asp Gly Arg Thr Tyr Gln Glu Gly Ala Asn Ala Asn Glu Leu Tyr 
            820                 825                 830         

Leu Glu Trp Lys Val Ala Tyr Gln Pro Gly Thr Leu Glu Ala Ile Ala 
        835                 840                 845             

Arg Asp Glu Ser Gly Lys Glu Ile Ala Arg Asp Lys Ile Thr Thr Ala 
    850                 855                 860                 

Gly Lys Pro Ala Ala Val Arg Leu Ile Lys Glu Asp His Ala Ile Ala 
865                 870                 875                 880 

Ala Asp Gly Lys Asp Leu Thr Tyr Ile Tyr Tyr Glu Ile Val Asp Ser 
                885                 890                 895     

Gln Gly Asn Val Val Pro Thr Ala Asn Asn Leu Val Arg Phe Gln Leu 
            900                 905                 910         

His Gly Gln Gly Gln Leu Val Gly Val Asp Asn Gly Glu Gln Ala Ser 
        915                 920                 925             

Arg Glu Arg Tyr Lys Ala Gln Ala Asp Gly Ser Trp Ile Arg Lys Ala 
    930                 935                 940                 

Phe Asn Gly Lys Gly Val Ala Ile Val Lys Ser Thr Glu Gln Ala Gly 
945                 950                 955                 960 

Lys Phe Thr Leu Thr Ala His Ser Asp Leu Leu Lys Ser Asn Gln Val 
                965                 970                 975     

Thr Val Phe Thr Gly Lys Lys Glu Gly Gln Glu Lys Thr Val Leu Gly 
            980                 985                 990         

Thr Glu Val Pro Lys Val Gln Thr Ile Ile Gly Glu Ala Pro Glu Met 
        995                 1000                1005            

Pro Thr Thr Val Pro Phe Val Tyr Ser Asp Gly Ser Arg Ala Glu Arg 
    1010                1015                1020                

Pro Val Thr Trp Ser Ser Val Asp Val Ser Lys Pro Gly Ile Val Thr 
1025                1030                1035                1040

Val Lys Gly Met Ala Asp Gly Arg Glu Val Glu Ala Arg Val Glu Val 
                1045                1050                1055    

Ile Ala Leu Lys Ser Glu Leu Pro Val Val Lys Arg Ile Ala Pro Asn 
            1060                1065                1070        

Thr Asp Leu Asn Ser Val Asp Lys Ser Val Ser Tyr Val Leu Ile Asp 
        1075                1080                1085            

Gly Ser Val Glu Glu Tyr Glu Val Asp Lys Trp Glu Ile Ala Glu Glu 
    1090                1095                1100                

Asp Lys Ala Lys Leu Ala Ile Pro Gly Ser Arg Ile Gln Ala Thr Gly 
1105                1110                1115                1120

Tyr Leu Glu Gly Gln Pro Ile His Ala Thr Leu Val Val Glu Glu Gly 
                1125                1130                1135    

Asn Pro Ala Ala Pro Ala Val Pro Thr Val Thr Val Gly Gly Glu Ala 
            1140                1145                1150        

Val Thr Gly Leu Thr Ser Gln Lys Pro Met Gln Tyr Arg Thr Leu Ala 
        1155                1160                1165            

Tyr Gly Ala Lys Leu Pro Glu Val Thr Ala Ser Ala Lys Asn Ala Ala 
    1170                1175                1180                

Val Thr Val Leu Gln Ala Ser Ala Ala Asn Gly Met Arg Ala Ser Ile 
1185                1190                1195                1200

Phe Ile Gln Pro Lys Asp Gly Gly Pro Leu Gln Thr Tyr Ala Ile Gln 
                1205                1210                1215    

Phe Leu Glu Glu Ala Pro Lys Ile Ala His Leu Ser Leu Gln Val Glu 
            1220                1225                1230        

Lys Ala Asp Ser Leu Lys Glu Asp Gln Thr Val Lys Leu Ser Val Arg 
        1235                1240                1245            

Ala His Tyr Gln Asp Gly Thr Gln Ala Val Leu Pro Ala Asp Lys Val 
    1250                1255                1260                

Thr Phe Ser Thr Ser Gly Glu Gly Glu Val Ala Ile Arg Lys Gly Met 
1265                1270                1275                1280

Leu Glu Leu His Lys Pro Gly Ala Val Thr Leu Asn Ala Glu Tyr Glu 
                1285                1290                1295    

Gly Ala Lys Asp Gln Val Glu Leu Thr Ile Gln Ala Asn Thr Glu Lys 
            1300                1305                1310        

Lys Ile Ala Gln Ser Ile Arg Pro Val Asn Val Val Thr Asp Leu His 
        1315                1320                1325            

Gln Glu Pro Ser Leu Pro Ala Thr Val Thr Val Glu Tyr Asp Lys Gly 
    1330                1335                1340                

Phe Pro Lys Thr His Lys Val Thr Trp Gln Ala Ile Pro Lys Glu Lys 
1345                1350                1355                1360

Leu Asp Ser Tyr Gln Thr Phe Glu Val Leu Gly Lys Val Glu Gly Ile 
                1365                1370                1375    

Asp Leu Glu Ala Arg Ala Lys Val Ser Val Glu Gly Ile Val Ser Val 
            1380                1385                1390        

Glu Glu Val Ser Val Thr Thr Pro Ile Ala Glu Ala Pro Gln Leu Pro 
        1395                1400                1405            

Glu Ser Val Arg Thr Tyr Asp Ser Asn Gly His Val Ser Ser Ala Lys 
    1410                1415                1420                

Val Ala Trp Asp Ala Ile Arg Pro Glu Gln Tyr Ala Lys Glu Gly Val 
1425                1430                1435                1440

Phe Thr Val Asn Gly Arg Leu Glu Gly Thr Gln Leu Thr Thr Lys Leu 
                1445                1450                1455    

His Val Arg Val Ser Ala Gln Thr Glu Gln Gly Ala Asn Ile Ser Asp 
            1460                1465                1470        

Gln Trp Thr Gly Ser Glu Leu Pro Leu Ala Phe Ala Ser Asp Ser Asn 
        1475                1480                1485            

Pro Ser Asp Pro Val Ser Asn Val Asn Asp Lys Leu Ile Ser Tyr Asn 
    1490                1495                1500                

Asn Gln Pro Ala Asn Arg Trp Thr Asn Trp Asn Arg Thr Asn Pro Glu 
1505                1510                1515                1520

Ala Ser Val Gly Val Leu Phe Gly Asp Ser Gly Ile Leu Ser Lys Arg 
                1525                1530                1535    

Ser Val Asp Asn Leu Ser Val Gly Phe His Glu Asp His Gly Val Gly 
            1540                1545                1550        

Val Pro Lys Ser Tyr Val Ile Glu Tyr Tyr Val Gly Lys Thr Val Pro 

        1555                1560                1565            

Thr Ala Pro Lys Asn Pro Ser Phe Val Gly Asn Glu Asp His Val Phe 
    1570                1575                1580                

Asn Asp Ser Ala Asn Trp Lys Pro Val Thr Asn Leu Lys Ala Pro Ala 
1585                1590                1595                1600

Gln Leu Lys Ala Gly Glu Met Asn His Phe Ser Phe Asp Lys Val Glu 
                1605                1610                1615    

Thr Tyr Ala Val Arg Ile Arg Met Val Lys Ala Asp Asn Lys Arg Gly 
            1620                1625                1630        

Thr Ser Ile Thr Glu Val Gln Ile Phe Ala Lys Gln Val Ala Ala Ala 
        1635                1640                1645            

Lys Gln Gly Gln Thr Arg Ile Gln Val Asp Gly Lys Asp Leu Ala Asn 
    1650                1655                1660                

Phe Asn Pro Asp Leu Thr Asp Tyr Tyr Leu Glu Ser Val Asp Gly Lys 
1665                1670                1675                1680

Val Pro Ala Val Thr Ala Ser Val Ser Asn Asn Gly Leu Ala Thr Val 
                1685                1690                1695    

Val Pro Ser Val Arg Glu Gly Glu Pro Val Arg Val Ile Ala Lys Ala 
            1700                1705                1710        

Glu Asn Gly Asp Ile Leu Gly Glu Tyr Arg Leu His Phe Thr Lys Asp 
        1715                1720                1725            

Lys Ser Leu Leu Ser His Lys Pro Val Ala Ala Val Lys Gln Ala Arg 
    1730                1735                1740                

Leu Leu Gln Val Gly Gln Ala Leu Glu Leu Pro Thr Lys Val Pro Val 
1745                1750                1755                1760

Tyr Phe Thr Gly Lys Asp Gly Tyr Glu Thr Lys Asp Leu Thr Val Glu 
                1765                1770                1775    

Trp Glu Glu Val Pro Ala Glu Asn Leu Thr Lys Ala Gly Gln Phe Thr 
            1780                1785                1790        

Val Arg Gly Arg Val Leu Gly Ser Asn Leu Val Ala Glu Ile Thr Val 
        1795                1800                1805            

Arg Val Thr Asp Lys Leu Gly Glu Thr Leu Ser Asp Asn Pro Asn Tyr 
    1810                1815                1820                

Asp Glu Asn Ser Asn Gln Ala Phe Ala Ser Ala Thr Asn Asp Ile Asp 
1825                1830                1835                1840

Lys Asn Ser His Asp Arg Val Asp Tyr Leu Asn Asp Gly Asp His Ser 
                1845                1850                1855    

Glu Asn Arg Arg Trp Thr Asn Trp Ser Pro Thr Pro Ser Ser Asn Pro 
            1860                1865                1870        

Glu Val Ser Ala Gly Val Ile Phe Arg Glu Asn Gly Lys Ile Val Glu 
        1875                1880                1885            

Arg Thr Val Thr Gln Gly Lys Val Gln Phe Phe Ala Asp Ser Gly Thr 
    1890                1895                1900                

Asp Ala Pro Ser Lys Leu Val Leu Glu Arg Tyr Val Gly Pro Glu Phe 
1905                1910                1915                1920

Glu Val Pro Thr Tyr Tyr Ser Asn Tyr Gln Ala Tyr Asp Ala Asp His 
                1925                1930                1935    

Pro Phe Asn Asn Pro Glu Asn Trp Glu Ala Val Pro Tyr Arg Ala Asp 
            1940                1945                1950        

Lys Asp Ile Ala Ala Gly Asp Glu Ile Asn Val Thr Phe Lys Ala Ile 
        1955                1960                1965            

Lys Ala Lys Ala Met Arg Trp Arg Met Glu Arg Lys Ala Asp Lys Ser 
    1970                1975                1980                

Gly Val Ala Met Ile Glu Met Thr Phe Leu Ala Pro Ser Glu Leu Pro 
1985                1990                1995                2000

Gln Glu Ser Thr Gln Ser Lys Ile Leu Val Asp Gly Lys Glu Leu Ala 
                2005                2010                2015    

Asp Phe Ala Glu Asn Arg Gln Asp Tyr Gln Ile Thr Tyr Lys Gly Gln 
            2020                2025                2030        

Arg Pro Lys Val Ser Val Glu Glu Asn Asn Gln Val Ala Ser Thr Val 
        2035                2040                2045            

Val Asp Ser Gly Glu Asp Ser Phe Pro Val Leu Val Arg Leu Val Ser 
    2050                2055                2060                

Glu Ser Gly Lys Gln Val Lys Glu Tyr Arg Ile His Leu Thr Lys Glu 
2065                2070                2075                2080

Lys Pro Val Ser Glu Lys Thr Val Ala Ala Val Gln Glu Asp Leu Pro 
                2085                2090                2095    

Lys Ile Glu Phe Val Glu Lys Asp Leu Ala Tyr Lys Thr Val Glu Lys 
            2100                2105                2110        

Lys Asp Ser Thr Leu Tyr Leu Gly Glu Thr Arg Val Glu Gln Glu Gly 
        2115                2120                2125            

Lys Val Gly Lys Glu Arg Ile Phe Thr Ala Ile Asn Pro Asp Gly Ser 
    2130                2135                2140                

Lys Glu Glu Lys Leu Arg Glu Val Val Glu Val Pro Thr Asp Arg Ile 
2145                2150                2155                2160

Val Leu Val Gly Thr Lys Pro Val Ala Gln Glu Ala Lys Lys Pro Gln 
                2165                2170                2175    

Val Ser Glu Lys Ala Asp Thr Lys Pro Ile Asp Ser Ser Glu Ala Ser 
            2180                2185                2190        

Gln Thr Asn Lys Ala Gln Leu Pro Ser Thr Gly Ser Ala Ala Ser Gln 
        2195                2200                2205            

Ala Ala Val Ala Ala Gly Leu Thr Leu Leu Gly Leu Ser Ala Gly Leu 
    2210                2215                2220                

Val Val Thr Lys Gly Lys Lys Glu Asp 
2225                2230            

<210>   1199
<211>   621
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1199
atggaagagt tagtgacctt agattgtttg tttattgaca gaactaagat tgaagccaat   60
gccaacaagt atagttttgt gtggaagaaa acgacagaga aattctccgc caaacttcaa   120
gaacagatac aggtctattt tcaagaagaa atcactcccc ttctgattaa atatgccatg   180
tttgataaga aacaaaagag agggtataaa gagtcagcta aaaacttagc gaattggcac   240
tataatgaca aggaggatag ctacacacat cctgatggct ggtattatcg ttttcaccat   300
accaaatatc agaaaacaca gacagacttt caacaagaaa tcaaggttta ctacgccgac   360
gaacctgaat cagcccctca aaagggactg tatatgaacg aacgctatca aaacttgaaa   420
gctaaagaat gtcaggcgct tttatctccc caaggtagac agattttcgc tcaacgcaag   480
attgatgtgg aacctgtctt tgggcagata aaggcttctt tgggttacaa gagatgtaat   540
ctgagaggga agcgtcaagt gagaattgac atgggattgg tacttatggc caataacctc   600
ctaaaatata gtaaaatgaa a                                             621

<210>   1200
<211>   207
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, degenerate

<400>   1200
Met Glu Glu Leu Val Thr Leu Asp Cys Leu Phe Ile Asp Arg Thr Lys 
1               5                   10                  15      

Ile Glu Ala Asn Ala Asn Lys Tyr Ser Phe Val Trp Lys Lys Thr Thr 
            20                  25                  30          

Glu Lys Phe Ser Ala Lys Leu Gln Glu Gln Ile Gln Val Tyr Phe Gln 
        35                  40                  45              

Glu Glu Ile Thr Pro Leu Leu Ile Lys Tyr Ala Met Phe Asp Lys Lys 
    50                  55                  60                  

Gln Lys Arg Gly Tyr Lys Glu Ser Ala Lys Asn Leu Ala Asn Trp His 
65                  70                  75                  80  

Tyr Asn Asp Lys Glu Asp Ser Tyr Thr His Pro Asp Gly Trp Tyr Tyr 
                85                  90                  95      

Arg Phe His His Thr Lys Tyr Gln Lys Thr Gln Thr Asp Phe Gln Gln 
            100                 105                 110         

Glu Ile Lys Val Tyr Tyr Ala Asp Glu Pro Glu Ser Ala Pro Gln Lys 
        115                 120                 125             

Gly Leu Tyr Met Asn Glu Arg Tyr Gln Asn Leu Lys Ala Lys Glu Cys 
    130                 135                 140                 

Gln Ala Leu Leu Ser Pro Gln Gly Arg Gln Ile Phe Ala Gln Arg Lys 
145                 150                 155                 160 

Ile Asp Val Glu Pro Val Phe Gly Gln Ile Lys Ala Ser Leu Gly Tyr 
                165                 170                 175     

Lys Arg Cys Asn Leu Arg Gly Lys Arg Gln Val Arg Ile Asp Met Gly 
            180                 185                 190         

Leu Val Leu Met Ala Asn Asn Leu Leu Lys Tyr Ser Lys Met Lys 
        195                 200                 205         

<210>   1201
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1201
gtggtgaata ccttggagga acgtcacttc tacacctcct atcatgcctt tgatcgcccg   60
tcttatcacc ctaaaatgct tgtatctact cttctatttg cctattcaca agggattttc   120
tctggtcgaa aaattgaaaa atggaagagt                                    150

<210>   1202
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1202
Met Val Asn Thr Leu Glu Glu Arg His Phe Tyr Thr Ser Tyr His Ala 
1               5                   10                  15      

Phe Asp Arg Pro Ser Tyr His Pro Lys Met Leu Val Ser Thr Leu Leu 
            20                  25                  30          

Phe Ala Tyr Ser Gln Gly Ile Phe Ser Gly Arg Lys Ile Glu Lys Trp 
        35                  40                  45              

Lys Ser 
    50  

<210>   1203
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1203
ttggatggtt acgatagtct tggtaaaata gaattgccca ataaaccatt tagaaaggct   60
atcccatgca tattcactat aacacaaatc aaacaacttt accac                   105

<210>   1204
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1204
Met Asp Gly Tyr Asp Ser Leu Gly Lys Ile Glu Leu Pro Asn Lys Pro 
1               5                   10                  15      

Phe Arg Lys Ala Ile Pro Cys Ile Phe Thr Ile Thr Gln Ile Lys Gln 
            20                  25                  30          

Leu Tyr His 
        35  

<210>   1205
<211>   318
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   1205
ttgatactga ccttagtcgt ctgcattatc ctaaccaaac tttttagatt aaaaaaacta   60
ggacgaaact ttgcggattt ggcttttcca gtcttggtat ttgagtatta cttgattaca   120
gctaaaacct ttacccataa tttcctccct agactggggc tagccctctc gatcctagcc   180
attattctcg tctttttctt ccttttgaaa aaacgcagct tttactaccc taaatttatc   240
aaattcttct ggcgtgcagg attcttatta acccttatca tgtatataga aatgattgtt   300
gaattgttct taatgaaa                                                 318

<210>   1206
<211>   106
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902612 (6.E-56)

<400>   1206
Met Ile Leu Thr Leu Val Val Cys Ile Ile Leu Thr Lys Leu Phe Arg 
1               5                   10                  15      

Leu Lys Lys Leu Gly Arg Asn Phe Ala Asp Leu Ala Phe Pro Val Leu 
            20                  25                  30          

Val Phe Glu Tyr Tyr Leu Ile Thr Ala Lys Thr Phe Thr His Asn Phe 
        35                  40                  45              

Leu Pro Arg Leu Gly Leu Ala Leu Ser Ile Leu Ala Ile Ile Leu Val 
    50                  55                  60                  

Phe Phe Phe Leu Leu Lys Lys Arg Ser Phe Tyr Tyr Pro Lys Phe Ile 
65                  70                  75                  80  

Lys Phe Phe Trp Arg Ala Gly Phe Leu Leu Thr Leu Ile Met Tyr Ile 
                85                  90                  95      

Glu Met Ile Val Glu Leu Phe Leu Met Lys 
            100                 105     

<210>   1207
<211>   1023

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1207
atggaaacga gaaacagagg aatttatagg aaagtcaggc ttttgagatt gtgggtgatt   60
tttgttataa tgaaagtcat gaaatcttat aataccttga atgattatta tcgaaaactc   120
tttggagaaa agacttttaa agtccctatt gatgcgggat ttgattgtcc caatcgtgat   180
gggactgtgg ctcatggggg ctgtactttt tgtacggttt ctggttctgg agatgccatt   240
gtggcaccgg atgcgcctat ccgtgagcaa ttttataagg aaattgactt tatgcaccgc   300
aagtggccgg atgttcggaa gtatctggtt tattttcaaa attttaccaa cacccatgaa   360
aaggtggaag ttattcgaga gcgttatgaa caggctatca atgagccagg tgtggtagga   420
atcaatattg gaacgcgccc agactgttta ccagacgaaa ccatcgaata tttggctgag   480
ttatcggagt gcatgcatgt gacggttgaa ttgggcttgc aaactactta tgaagcaacc   540
tctgacctga ttaaccgtgc gcattcttat gaattgtagg tggaaacggt caagcgtttg   600
agaaagtatc caaaaattga gattgtttcc catttgatca atggtttgcc tggtgaaacc   660
catgagatga tggttgaaaa tgtccgccgt tgtgtcacgg ataacgatat tcaagggatt   720
aaactgcatt tgctccatct tatgacaaat actcgtatgc aacgagatta ccatgagggg   780
cgtttacaat tgatgagtca ggacgaatat gtcagggtca tctgtgacca actggaaatt   840
attcccaaac atatcgtcat ccatcgaatt acaggagatg cgcctaggga tatgctgctt   900
ggtcctatgt ggagcctcaa taaatgggaa gtcctcaaca gcattgagat ggagatgcga   960
cgtcgtggaa gtgttcaagg atgcaaggct gtaaaacagg agtttgaaaa tgaaaagacc   1020
act                                                                 1023


<210>   1208
<400>   1208
000

<210>   1209
<211>   555
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1209
atgaaaagac cacttgagat ggcacatgat tttttggctg aggtcgtgac aaaagaggat   60
gtcgtagtgg atgcgactat gggaaatggt catgacacgc tttttttagc caagctagcc   120
aagcaagtct atgcctttga tattcagaag caagccttgg aaaagaccca agagcgtttg   180
catcaggctg acttgacaaa tgcccagtta atcttgcaag gccatgagac actggaccag   240
tttgtgataa aagctaaggc agggattttt aatctgggct atttgccggc agctgataag   300
tctgtcatca cccgaccgca gacaacgatt gaggcattag aaaagctatg tggcttactt   360
gtcaaaggtg gacgaattgc tattatgatt tactatggtc atgaaggagg cgatctcgag   420
agagatgctg tcttggattt tgtgatccag ttgaaccaac aagagtacac agctgccatt   480
taccgaactt taaaccaagt caacaacccg ccgtttttag tgatgattga aaaattagag   540
agatacagac atgga                                                    555

<210>   1210
<211>   185
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902615 (e-101)

<400>   1210
Met Lys Arg Pro Leu Glu Met Ala His Asp Phe Leu Ala Glu Val Val 
1               5                   10                  15      

Thr Lys Glu Asp Val Val Val Asp Ala Thr Met Gly Asn Gly His Asp 
            20                  25                  30          

Thr Leu Phe Leu Ala Lys Leu Ala Lys Gln Val Tyr Ala Phe Asp Ile 
        35                  40                  45              

Gln Lys Gln Ala Leu Glu Lys Thr Gln Glu Arg Leu His Gln Ala Asp 
    50                  55                  60                  

Leu Thr Asn Ala Gln Leu Ile Leu Gln Gly His Glu Thr Leu Asp Gln 
65                  70                  75                  80  

Phe Val Ile Lys Ala Lys Ala Gly Ile Phe Asn Leu Gly Tyr Leu Pro 
                85                  90                  95      

Ala Ala Asp Lys Ser Val Ile Thr Arg Pro Gln Thr Thr Ile Glu Ala 
            100                 105                 110         

Leu Glu Lys Leu Cys Gly Leu Leu Val Lys Gly Gly Arg Ile Ala Ile 
        115                 120                 125             

Met Ile Tyr Tyr Gly His Glu Gly Gly Asp Leu Glu Arg Asp Ala Val 
    130                 135                 140                 

Leu Asp Phe Val Ile Gln Leu Asn Gln Gln Glu Tyr Thr Ala Ala Ile 
145                 150                 155                 160 

Tyr Arg Thr Leu Asn Gln Val Asn Asn Pro Pro Phe Leu Val Met Ile 
                165                 170                 175     

Glu Lys Leu Glu Arg Tyr Arg His Gly 
            180                 185 

<210>   1211
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1211
atggataaac aatacttaca cgaaaagctg gatgccatgc gccagaattt tgttgaatca   60
acccaccacg aacgagcgat gggcgtgcta gaccaagcgc atatgagcaa aaaaatgctt   120
aaaatcaaga aaaaattagt tgctcttgaa atggaacggt gccagagaaa aattgagcac   180
aaagactgtt ccaagattga ccaaaaaatc aaagagcaga aggagatatt tgaatcctgt   240
tgtaaaaaag at                                                       252

<210>   1212
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902616 (5.E-45)

<400>   1212
Met Asp Lys Gln Tyr Leu His Glu Lys Leu Asp Ala Met Arg Gln Asn 
1               5                   10                  15      

Phe Val Glu Ser Thr His His Glu Arg Ala Met Gly Val Leu Asp Gln 
            20                  25                  30          

Ala His Met Ser Lys Lys Met Leu Lys Ile Lys Lys Lys Leu Val Ala 
        35                  40                  45              

Leu Glu Met Glu Arg Cys Gln Arg Lys Ile Glu His Lys Asp Cys Ser 
    50                  55                  60                  

Lys Ile Asp Gln Lys Ile Lys Glu Gln Lys Glu Ile Phe Glu Ser Cys 
65                  70                  75                  80  

Cys Lys Lys Asp 
                

<210>   1213
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1213
ttgaatcctg ttgtaaaaaa gattaaggag gacgtgcgtg gaattactga tttacctcat   60
cctattttta ctggttttga ttgtctcaag tacaaccaa                          99

<210>   1214
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1214
Met Asn Pro Val Val Lys Lys Ile Lys Glu Asp Val Arg Gly Ile Thr 
1               5                   10                  15      

Asp Leu Pro His Pro Ile Phe Thr Gly Phe Asp Cys Leu Lys Tyr Asn 
            20                  25                  30          

Gln 
    

<210>   1215
<211>   1086
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1215
ttgattgtct caagtacaac caataagctc ctgccctttt tgcctctccc tttggtgcaa   60
attcttttgg gaattgtgat tggtctcttt ttacccaata ctgactttca ccttaatacg   120
gagttgtttt tggcactggt tatcggaccc ttgcttttcc gagaggctga agaagcagat   180
gttacggcta ttttaaaaca ctggcgaatc attgtttatc tcatatttcc agtgattttt   240
atctcgaccc tgagtttggg tggcttggcc catcttcttt ggttcagcct tcccttggca   300
gcttgcttgg ctgttggggc agcccttggt cctacggact tggtggcctt tgcctctctt   360
tcggagcgtt ttagctttcc taagcgcgtg tccaatattc ttaagggcga aggactcttg   420
aatgatgctt ctggtttggt ggcttttcag gtagctttga cagcttggac aactggagct   480
ttttctctgg ggcaagctag cagttcgctc atcttttcaa tcctaggcgg ttttttaatt   540
ggatttttaa cagccatgac caaccgcttc ctccatacct tcttgctaag tgtgcgcgca   600
acggatattg ccagtgaact tttattagaa ttgagtttgc ctctagtgac cttctttctg   660
gcagaagaag ttcatgtttc aggtattatt gccgtcgtag ttgctggaat tttaaaggca   720
agtcgcttca agaaaatcac gctcctcgaa gcccaagtgg atacggtgac cgagacggtc   780
tggcatacag tgacctttat gctcaacggt tctgtctttg tgattttagg gatggagttg   840
gaaatgatag cagaacctat cttgaccaat ccaatctata atcctctact tttattgcta   900
tctcttatcg cccttacctt tgtccttttt gtcattcgtt ttattatgat ctatggctat   960
tatgcctata gaacccgacg cctcaagaaa aagctaaata agtatatgaa ggacatgttt   1020
ctcttgacct tttcaggtgt taagggaacg gtgtcgattg ctacgattct cttgatacca   1080
agtaat                                                              1086

<210>   1216
<211>   362
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sodium/hydrogen exchanger family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902617 (0.E+01)

<400>   1216
Met Ile Val Ser Ser Thr Thr Asn Lys Leu Leu Pro Phe Leu Pro Leu 
1               5                   10                  15      

Pro Leu Val Gln Ile Leu Leu Gly Ile Val Ile Gly Leu Phe Leu Pro 
            20                  25                  30          

Asn Thr Asp Phe His Leu Asn Thr Glu Leu Phe Leu Ala Leu Val Ile 
        35                  40                  45              

Gly Pro Leu Leu Phe Arg Glu Ala Glu Glu Ala Asp Val Thr Ala Ile 
    50                  55                  60                  

Leu Lys His Trp Arg Ile Ile Val Tyr Leu Ile Phe Pro Val Ile Phe 
65                  70                  75                  80  

Ile Ser Thr Leu Ser Leu Gly Gly Leu Ala His Leu Leu Trp Phe Ser 
                85                  90                  95      

Leu Pro Leu Ala Ala Cys Leu Ala Val Gly Ala Ala Leu Gly Pro Thr 
            100                 105                 110         

Asp Leu Val Ala Phe Ala Ser Leu Ser Glu Arg Phe Ser Phe Pro Lys 
        115                 120                 125             

Arg Val Ser Asn Ile Leu Lys Gly Glu Gly Leu Leu Asn Asp Ala Ser 
    130                 135                 140                 

Gly Leu Val Ala Phe Gln Val Ala Leu Thr Ala Trp Thr Thr Gly Ala 
145                 150                 155                 160 

Phe Ser Leu Gly Gln Ala Ser Ser Ser Leu Ile Phe Ser Ile Leu Gly 
                165                 170                 175     

Gly Phe Leu Ile Gly Phe Leu Thr Ala Met Thr Asn Arg Phe Leu His 
            180                 185                 190         

Thr Phe Leu Leu Ser Val Arg Ala Thr Asp Ile Ala Ser Glu Leu Leu 
        195                 200                 205             

Leu Glu Leu Ser Leu Pro Leu Val Thr Phe Phe Leu Ala Glu Glu Val 
    210                 215                 220                 

His Val Ser Gly Ile Ile Ala Val Val Val Ala Gly Ile Leu Lys Ala 
225                 230                 235                 240 

Ser Arg Phe Lys Lys Ile Thr Leu Leu Glu Ala Gln Val Asp Thr Val 
                245                 250                 255     

Thr Glu Thr Val Trp His Thr Val Thr Phe Met Leu Asn Gly Ser Val 
            260                 265                 270         

Phe Val Ile Leu Gly Met Glu Leu Glu Met Ile Ala Glu Pro Ile Leu 
        275                 280                 285             

Thr Asn Pro Ile Tyr Asn Pro Leu Leu Leu Leu Leu Ser Leu Ile Ala 
    290                 295                 300                 

Leu Thr Phe Val Leu Phe Val Ile Arg Phe Ile Met Ile Tyr Gly Tyr 
305                 310                 315                 320 


Tyr Ala Tyr Arg Thr Arg Arg Leu Lys Lys Lys Leu Asn Lys Tyr Met 
                325                 330                 335     

Lys Asp Met Phe Leu Leu Thr Phe Ser Gly Val Lys Gly Thr Val Ser 
            340                 345                 350         

Ile Ala Thr Ile Leu Leu Ile Pro Ser Asn 
        355                 360         

<210>   1217
<211>   906
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1217
ttgcttttcc ttgttgcagg tgtgacgctt gttagctttt taacaggtct cttggtcttg   60
cctcatcttt ctgatgaaga ggaagaaagc aaggattatc ttatgcatat cgccattttg   120
aatgaagtaa cgctagagtt ggaaaaagag ttggaagaca ccagaaataa acttcccctc   180
tatgcggcta ttgacaatta tcatggacgt attgaaaatc tcattttaag ccaagaaaac   240
caggatgatc aagaagactg ggctgctttg aaactcttga ttcttagtat tgaaagtgat   300
ggtttggaac aggcctatga agaggggaac attagcaatc gtgcttaccg agtttaccaa   360
cgttatctga aaaatataga acaaggaatc aatcgtaaac ttgcctcaag actgacctat   420
tattttcttg tttccttgag gattttacgt tttctccttc atgaagtttt tactctcgga   480
aagaccttcc gtagctggaa gaacaaggag caaagccgtc tccgtgctct tgattatgac   540
caaattgcag agctctatct tgccaataca gagatgatta ttgaaagttt ggaaaacctg   600
aagggagtct acagacgctc tttgattagt tttatgcagg agtctcgtct tcgagaaaca   660
gctattatca gcagtggtgc ctttgtcgaa cgggttatca atcgtgtcaa acccaacaat   720
atcgatgaaa tgctgagagg ctattatctg gagcgcaagt tgattttcga atacgaagaa   780
aaacgattga ttacgactaa gtatgccaag aaattacgac aaaatgtaaa taacttagag   840
aactattcct tgaaggaagc tgccaatacc ctaccgtatg atatggtgga attggtaaga   900
agaaat                                                              906

<210>   1218
<211>   302
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Na+/H+ antiporter)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902617 (e-167)

<400>   1218
Met Leu Phe Leu Val Ala Gly Val Thr Leu Val Ser Phe Leu Thr Gly 
1               5                   10                  15      

Leu Leu Val Leu Pro His Leu Ser Asp Glu Glu Glu Glu Ser Lys Asp 
            20                  25                  30          

Tyr Leu Met His Ile Ala Ile Leu Asn Glu Val Thr Leu Glu Leu Glu 
        35                  40                  45              

Lys Glu Leu Glu Asp Thr Arg Asn Lys Leu Pro Leu Tyr Ala Ala Ile 
    50                  55                  60                  

Asp Asn Tyr His Gly Arg Ile Glu Asn Leu Ile Leu Ser Gln Glu Asn 
65                  70                  75                  80  

Gln Asp Asp Gln Glu Asp Trp Ala Ala Leu Lys Leu Leu Ile Leu Ser 
                85                  90                  95      

Ile Glu Ser Asp Gly Leu Glu Gln Ala Tyr Glu Glu Gly Asn Ile Ser 
            100                 105                 110         

Asn Arg Ala Tyr Arg Val Tyr Gln Arg Tyr Leu Lys Asn Ile Glu Gln 
        115                 120                 125             

Gly Ile Asn Arg Lys Leu Ala Ser Arg Leu Thr Tyr Tyr Phe Leu Val 
    130                 135                 140                 

Ser Leu Arg Ile Leu Arg Phe Leu Leu His Glu Val Phe Thr Leu Gly 
145                 150                 155                 160 

Lys Thr Phe Arg Ser Trp Lys Asn Lys Glu Gln Ser Arg Leu Arg Ala 
                165                 170                 175     

Leu Asp Tyr Asp Gln Ile Ala Glu Leu Tyr Leu Ala Asn Thr Glu Met 
            180                 185                 190         

Ile Ile Glu Ser Leu Glu Asn Leu Lys Gly Val Tyr Arg Arg Ser Leu 
        195                 200                 205             

Ile Ser Phe Met Gln Glu Ser Arg Leu Arg Glu Thr Ala Ile Ile Ser 
    210                 215                 220                 

Ser Gly Ala Phe Val Glu Arg Val Ile Asn Arg Val Lys Pro Asn Asn 
225                 230                 235                 240 

Ile Asp Glu Met Leu Arg Gly Tyr Tyr Leu Glu Arg Lys Leu Ile Phe 
                245                 250                 255     

Glu Tyr Glu Glu Lys Arg Leu Ile Thr Thr Lys Tyr Ala Lys Lys Leu 
            260                 265                 270         

Arg Gln Asn Val Asn Asn Leu Glu Asn Tyr Ser Leu Lys Glu Ala Ala 
        275                 280                 285             

Asn Thr Leu Pro Tyr Asp Met Val Glu Leu Val Arg Arg Asn 
    290                 295                 300         

<210>   1219
<211>   858
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1219
atgaaaaagt ggtggaaaga gctgatagac aaacctttat taaaagcttt tttgcattat   60
tatcaagcat cagatagtga gttgaccagt gtcgcagtag cctactattg gttgatttcg   120
attttccccc tgcttttggt ggtggtcaat atcctcccct attttcagat tcctgtggga   180
gaatttttgg gctttatgaa agacgtcctg cccccaagcc tctatgaagg tgtggaaaaa   240
atagccagag aagtcttgac gcaaccttca acaggtttat tgagtttttc tgttttatcg   300
gcgttatgga gtttttcaaa atctatgaat ttcttgcaaa aagcttttaa caaggcttat   360
ggcgtcgaaa agagtcgtgg acttatttcc catcagatgc taagtctcct agtcagtttt   420
ggcttgcagc tcctctttgc gtttgccttg tttttgatct tatttggtca gatgattttg   480
gctttacttg ctcattattg gacaaaagat ggcattatct atcaggcttt acaagggttg   540
gcaggtcctc tgatttacgc cctcctcttt gctatcttgg tcatgcttta ttattttctt   600
cccaatctat ctaacaggaa aattagctat accctaccag gcagtgcctt tgttctctta   660
gtgattttag gtttactaac tctgttctct agttatctca attactatgt ccatcatttg   720
gtggatgtcc gaattttagg ttccgttctt cttgttgtta tgatgttttg gtttatcttg   780
attgctaaaa ttgttatcct aggcgcggtg atcaatgcca gtatgcagag tttgaaagat   840
ccggtcttta aaaaagac                                                 858

<210>   1220
<211>   286
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902618 (e-159)

<400>   1220
Met Lys Lys Trp Trp Lys Glu Leu Ile Asp Lys Pro Leu Leu Lys Ala 
1               5                   10                  15      

Phe Leu His Tyr Tyr Gln Ala Ser Asp Ser Glu Leu Thr Ser Val Ala 
            20                  25                  30          

Val Ala Tyr Tyr Trp Leu Ile Ser Ile Phe Pro Leu Leu Leu Val Val 
        35                  40                  45              

Val Asn Ile Leu Pro Tyr Phe Gln Ile Pro Val Gly Glu Phe Leu Gly 
    50                  55                  60                  

Phe Met Lys Asp Val Leu Pro Pro Ser Leu Tyr Glu Gly Val Glu Lys 
65                  70                  75                  80  

Ile Ala Arg Glu Val Leu Thr Gln Pro Ser Thr Gly Leu Leu Ser Phe 
                85                  90                  95      

Ser Val Leu Ser Ala Leu Trp Ser Phe Ser Lys Ser Met Asn Phe Leu 
            100                 105                 110         

Gln Lys Ala Phe Asn Lys Ala Tyr Gly Val Glu Lys Ser Arg Gly Leu 
        115                 120                 125             

Ile Ser His Gln Met Leu Ser Leu Leu Val Ser Phe Gly Leu Gln Leu 
    130                 135                 140                 

Leu Phe Ala Phe Ala Leu Phe Leu Ile Leu Phe Gly Gln Met Ile Leu 
145                 150                 155                 160 

Ala Leu Leu Ala His Tyr Trp Thr Lys Asp Gly Ile Ile Tyr Gln Ala 
                165                 170                 175     

Leu Gln Gly Leu Ala Gly Pro Leu Ile Tyr Ala Leu Leu Phe Ala Ile 
            180                 185                 190         

Leu Val Met Leu Tyr Tyr Phe Leu Pro Asn Leu Ser Asn Arg Lys Ile 
        195                 200                 205             

Ser Tyr Thr Leu Pro Gly Ser Ala Phe Val Leu Leu Val Ile Leu Gly 
    210                 215                 220                 

Leu Leu Thr Leu Phe Ser Ser Tyr Leu Asn Tyr Tyr Val His His Leu 
225                 230                 235                 240 

Val Asp Val Arg Ile Leu Gly Ser Val Leu Leu Val Val Met Met Phe 
                245                 250                 255     

Trp Phe Ile Leu Ile Ala Lys Ile Val Ile Leu Gly Ala Val Ile Asn 
            260                 265                 270         

Ala Ser Met Gln Ser Leu Lys Asp Pro Val Phe Lys Lys Asp 
        275                 280                 285     

<210>   1221
<211>   708
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1221
atgggtcata ttttcttttt tctaagtgtc tttttggcag ggattctatc cttcttttct   60
ccttgtatct tacctttgtt accggtctat acaggagtgt tactagatga taaggatggt   120
gctcaggctt ctagcggcaa attttcaatc tcagttacta gtttattacg aactctggcc   180
tttatagcag gaatttcctt tatatttatt ttgttgggct atggagctgg ttttttaggc   240
gatttgcttt atgcttcttg gttccaatat cttactgggg caattattat ccttcttggt   300
ttgcaccaaa tggagattct acactttaag gggctttata aggaaaagag gctacaactg   360
caaggacagg ggcaaaatgg taagggctat agtcaggcat ttttattggg cttgaccttt   420
agttttgctt ggacgccttg cgtggggccg gttctggggt ctgttttggc cttggcggct   480
tcaggtggtt caggagcttg gcagggagct ggtctcatgt tggtgtatac gctgggcttg   540
gcgctaccat tcttgcttct agctctgacc tctagttatg ttttgaaaca tttccgaaaa   600
cttcatccct atctcggaat cctcaaaaaa gtgggtggtt ttctcattat tgtgatgggc   660
ttcttggttc tgtttggaaa tgcttcaatt ttaagtcaat tatttgaa                708


<210>   1222
<211>   236
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cytochrome c-type biogenesis protein CcdA (ccdA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902619 (e-133)

<400>   1222
Met Gly His Ile Phe Phe Phe Leu Ser Val Phe Leu Ala Gly Ile Leu 
1               5                   10                  15      

Ser Phe Phe Ser Pro Cys Ile Leu Pro Leu Leu Pro Val Tyr Thr Gly 
            20                  25                  30          

Val Leu Leu Asp Asp Lys Asp Gly Ala Gln Ala Ser Ser Gly Lys Phe 
        35                  40                  45              

Ser Ile Ser Val Thr Ser Leu Leu Arg Thr Leu Ala Phe Ile Ala Gly 
    50                  55                  60                  

Ile Ser Phe Ile Phe Ile Leu Leu Gly Tyr Gly Ala Gly Phe Leu Gly 
65                  70                  75                  80  

Asp Leu Leu Tyr Ala Ser Trp Phe Gln Tyr Leu Thr Gly Ala Ile Ile 
                85                  90                  95      

Ile Leu Leu Gly Leu His Gln Met Glu Ile Leu His Phe Lys Gly Leu 
            100                 105                 110         

Tyr Lys Glu Lys Arg Leu Gln Leu Gln Gly Gln Gly Gln Asn Gly Lys 
        115                 120                 125             

Gly Tyr Ser Gln Ala Phe Leu Leu Gly Leu Thr Phe Ser Phe Ala Trp 
    130                 135                 140                 

Thr Pro Cys Val Gly Pro Val Leu Gly Ser Val Leu Ala Leu Ala Ala 
145                 150                 155                 160 

Ser Gly Gly Ser Gly Ala Trp Gln Gly Ala Gly Leu Met Leu Val Tyr 
                165                 170                 175     

Thr Leu Gly Leu Ala Leu Pro Phe Leu Leu Leu Ala Leu Thr Ser Ser 
            180                 185                 190         

Tyr Val Leu Lys His Phe Arg Lys Leu His Pro Tyr Leu Gly Ile Leu 
        195                 200                 205             

Lys Lys Val Gly Gly Phe Leu Ile Ile Val Met Gly Phe Leu Val Leu 
    210                 215                 220                 

Phe Gly Asn Ala Ser Ile Leu Ser Gln Leu Phe Glu 
225                 230                 235     

<210>   1223
<211>   564
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1223
atgaaaaaat ggcaaacatg tgttcttgga gcaggttcgc tcctttgttt gacggcttgt   60
tcaggcaagt ccgtgactag tgaacaccaa acgaaagatg aaatgaagac ggagcagaca   120
gctagtaaaa caagcgcagc taaagggaaa gaggtggctg attttgaatt gatgggagta   180
gatggcaaga cctaccgttt atctgattac aagggcaaga aagtctatct caaattctgg   240
gcttcttggt gttccatctg tctggctagt cttccagata cggatgagat tgctaaagaa   300
gctggtgatg actatgtggt cttgacagta gtgtcaccag gacataaggg agagcaatct   360
gaagcggact ttaagaattg gtataaggga ttggattata aaaatctccc agtcctagtt   420
gacccatcag gcaaactttt ggaaacttat ggtgtccgtt cttacccaac ccaagccttt   480
atagacaaag aaggcaagct ggtcaaaaca catccaggat tcatggaaaa agatgcaatt   540
ttgcaaactt tgaaggaatt agcc                                          564

<210>   1224
<211>   188
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thioredoxin family protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902620 (e-109)

<400>   1224
Met Lys Lys Trp Gln Thr Cys Val Leu Gly Ala Gly Ser Leu Leu Cys 
1               5                   10                  15      

Leu Thr Ala Cys Ser Gly Lys Ser Val Thr Ser Glu His Gln Thr Lys 
            20                  25                  30          

Asp Glu Met Lys Thr Glu Gln Thr Ala Ser Lys Thr Ser Ala Ala Lys 
        35                  40                  45              

Gly Lys Glu Val Ala Asp Phe Glu Leu Met Gly Val Asp Gly Lys Thr 
    50                  55                  60                  

Tyr Arg Leu Ser Asp Tyr Lys Gly Lys Lys Val Tyr Leu Lys Phe Trp 
65                  70                  75                  80  

Ala Ser Trp Cys Ser Ile Cys Leu Ala Ser Leu Pro Asp Thr Asp Glu 
                85                  90                  95      

Ile Ala Lys Glu Ala Gly Asp Asp Tyr Val Val Leu Thr Val Val Ser 
            100                 105                 110         

Pro Gly His Lys Gly Glu Gln Ser Glu Ala Asp Phe Lys Asn Trp Tyr 
        115                 120                 125             

Lys Gly Leu Asp Tyr Lys Asn Leu Pro Val Leu Val Asp Pro Ser Gly 
    130                 135                 140                 

Lys Leu Leu Glu Thr Tyr Gly Val Arg Ser Tyr Pro Thr Gln Ala Phe 
145                 150                 155                 160 

Ile Asp Lys Glu Gly Lys Leu Val Lys Thr His Pro Gly Phe Met Glu 
                165                 170                 175     

Lys Asp Ala Ile Leu Gln Thr Leu Lys Glu Leu Ala 
            180                 185             

<210>   1225
<211>   1110
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1225
atgaatgata agttaaaaat cttcttgttg ctaggagtat tttttctagc cataaccggt   60
ttctatgttc tattgatacg aaatgcaggg cagacagatg cctcgcaaat tgaaaaggcg   120
gcagttagcc aaggaggaaa agcagtgaaa aaaacagaaa ttagtaaaga cgcagacttg   180
cacgaaattt atctagctgg aggttgtttc tggggagtgg aggaatattt ctcacgtgtt   240
cccggggtga cggatgccgt ttcaggctat gcaaatggta gaggagaaac aaccaagtac   300
gaattgatta accaaacagg tcatgcagaa accgtccatg tcacctatga tgccaagcaa   360
atttctctca aggaaatcct gcttcactat ttccgcatta tcaatccaac cagcaaaaat   420
aaacaaggaa atgatgtggg gacccagtac cgtactggtg tttattacac agatgacaag   480
gatttggaag tgattaacca agtctttgat gaggtggcta agaaatacga tcaacctcta   540
gcagttgaaa aggaaaactt gaagaatttt gtggtggctg aggattacca tcaagactat   600
ctcaagaaaa atccaaatgg ctactgccat atcaatgtta atcaggcggc ctatcctgtc   660
attgatgcca gcaaatatcc aaaaccaagt gatgaggaat tgaaaaagac cctgtcacct   720
gaggagtatg cagttaccca ggaaaatcaa acagaacgag ctttctcaaa ccgttactgg   780
gataaatttg aatccggtat ctatgtggat atagcaactg gggaacctct cttttcatca   840
aaagacaaat ttgagtctgg ttgtggctgg cctagtttta cccaacccat cagtccagat   900
gttgtcacct acaaggaaga taagtcctac aatatgacgc gtatggaagt gcggagccga   960
gtaggagatt ctcaccttgg gcatgtcttt acggatggtc cacaggacaa gggcggctta   1020
cgttactgta tcaatagcct ctctatccgc tttattccca aagaccaaat ggaagaaaaa   1080
ggctacgctt atttactaga ttatgttgat                                    1110

<210>   1226
<211>   370
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptide methionine sulfoxide reductase (msrA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902621 (0.E+01)

<400>   1226
Met Asn Asp Lys Leu Lys Ile Phe Leu Leu Leu Gly Val Phe Phe Leu 
1               5                   10                  15      

Ala Ile Thr Gly Phe Tyr Val Leu Leu Ile Arg Asn Ala Gly Gln Thr 
            20                  25                  30          

Asp Ala Ser Gln Ile Glu Lys Ala Ala Val Ser Gln Gly Gly Lys Ala 
        35                  40                  45              

Val Lys Lys Thr Glu Ile Ser Lys Asp Ala Asp Leu His Glu Ile Tyr 
    50                  55                  60                  

Leu Ala Gly Gly Cys Phe Trp Gly Val Glu Glu Tyr Phe Ser Arg Val 
65                  70                  75                  80  

Pro Gly Val Thr Asp Ala Val Ser Gly Tyr Ala Asn Gly Arg Gly Glu 
                85                  90                  95      

Thr Thr Lys Tyr Glu Leu Ile Asn Gln Thr Gly His Ala Glu Thr Val 
            100                 105                 110         

His Val Thr Tyr Asp Ala Lys Gln Ile Ser Leu Lys Glu Ile Leu Leu 
        115                 120                 125             

His Tyr Phe Arg Ile Ile Asn Pro Thr Ser Lys Asn Lys Gln Gly Asn 
    130                 135                 140                 

Asp Val Gly Thr Gln Tyr Arg Thr Gly Val Tyr Tyr Thr Asp Asp Lys 
145                 150                 155                 160 

Asp Leu Glu Val Ile Asn Gln Val Phe Asp Glu Val Ala Lys Lys Tyr 
                165                 170                 175     

Asp Gln Pro Leu Ala Val Glu Lys Glu Asn Leu Lys Asn Phe Val Val 
            180                 185                 190         

Ala Glu Asp Tyr His Gln Asp Tyr Leu Lys Lys Asn Pro Asn Gly Tyr 
        195                 200                 205             

Cys His Ile Asn Val Asn Gln Ala Ala Tyr Pro Val Ile Asp Ala Ser 
    210                 215                 220                 

Lys Tyr Pro Lys Pro Ser Asp Glu Glu Leu Lys Lys Thr Leu Ser Pro 
225                 230                 235                 240 

Glu Glu Tyr Ala Val Thr Gln Glu Asn Gln Thr Glu Arg Ala Phe Ser 
                245                 250                 255     

Asn Arg Tyr Trp Asp Lys Phe Glu Ser Gly Ile Tyr Val Asp Ile Ala 
            260                 265                 270         

Thr Gly Glu Pro Leu Phe Ser Ser Lys Asp Lys Phe Glu Ser Gly Cys 
        275                 280                 285             

Gly Trp Pro Ser Phe Thr Gln Pro Ile Ser Pro Asp Val Val Thr Tyr 
    290                 295                 300                 

Lys Glu Asp Lys Ser Tyr Asn Met Thr Arg Met Glu Val Arg Ser Arg 
305                 310                 315                 320 

Val Gly Asp Ser His Leu Gly His Val Phe Thr Asp Gly Pro Gln Asp 
                325                 330                 335     

Lys Gly Gly Leu Arg Tyr Cys Ile Asn Ser Leu Ser Ile Arg Phe Ile 
            340                 345                 350         

Pro Lys Asp Gln Met Glu Glu Lys Gly Tyr Ala Tyr Leu Leu Asp Tyr 
        355                 360                 365             

Val Asp 
    370 

<210>   1227
<211>   753
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1227
gtggtaaagg agcagagcat gacctacaca atcttaatcg tagaagatga atatctggta   60
agacaaggtt tgactaaact ggtcaatgta gcagcctacg atatggaaat catcggtcag   120
gctgaaaatg gaaggcaggc ttgggaattg atccaaaagc aggtgccaga tatcatttta   180
accgatatca acatgcctca tctaaatggc atccagttgg ccagtctggt acgagaaacc   240
tatcctcagg ttcatttggt ctttttaaca ggttacgatg attttgatta tgccttgtct   300
gctgtcaaac taggtgtgga cgactacctg ctcaaaccct tttctcgtca ggatattgag   360
gaaatgttgg ggaaaatcaa acaaaaacta gacaaggaag agaaagaaga gcagttacaa   420
gatttattga ctaataggtt tgaaggaaac atggcccaga aaatccagtc tcatctggct   480
gatagccaat ttagtttaaa gtctttagcc agtgacttag gttttagtcc gacctatctg   540
agttccttga ttaagaaaga gttgggcttg ccttttcagg attatctggt gagagaacgt   600
gttaaacaag ccaagctctt gcttttaact acagatctga agatttatga gatcgcagag   660
aaggttggtt ttgaagatat gaactatttt acccaacgtt ttaagcagat tgcaggtgtg   720
acacctcgtc agtttaagaa gggagaagac cga                                753

<210>   1228
<211>   251
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902622 (e-137)

<400>   1228
Met Val Lys Glu Gln Ser Met Thr Tyr Thr Ile Leu Ile Val Glu Asp 
1               5                   10                  15      

Glu Tyr Leu Val Arg Gln Gly Leu Thr Lys Leu Val Asn Val Ala Ala 
            20                  25                  30          

Tyr Asp Met Glu Ile Ile Gly Gln Ala Glu Asn Gly Arg Gln Ala Trp 
        35                  40                  45              

Glu Leu Ile Gln Lys Gln Val Pro Asp Ile Ile Leu Thr Asp Ile Asn 
    50                  55                  60                  

Met Pro His Leu Asn Gly Ile Gln Leu Ala Ser Leu Val Arg Glu Thr 
65                  70                  75                  80  

Tyr Pro Gln Val His Leu Val Phe Leu Thr Gly Tyr Asp Asp Phe Asp 
                85                  90                  95      

Tyr Ala Leu Ser Ala Val Lys Leu Gly Val Asp Asp Tyr Leu Leu Lys 
            100                 105                 110         

Pro Phe Ser Arg Gln Asp Ile Glu Glu Met Leu Gly Lys Ile Lys Gln 
        115                 120                 125             

Lys Leu Asp Lys Glu Glu Lys Glu Glu Gln Leu Gln Asp Leu Leu Thr 
    130                 135                 140                 

Asn Arg Phe Glu Gly Asn Met Ala Gln Lys Ile Gln Ser His Leu Ala 
145                 150                 155                 160 

Asp Ser Gln Phe Ser Leu Lys Ser Leu Ala Ser Asp Leu Gly Phe Ser 
                165                 170                 175     

Pro Thr Tyr Leu Ser Ser Leu Ile Lys Lys Glu Leu Gly Leu Pro Phe 
            180                 185                 190         

Gln Asp Tyr Leu Val Arg Glu Arg Val Lys Gln Ala Lys Leu Leu Leu 
        195                 200                 205             

Leu Thr Thr Asp Leu Lys Ile Tyr Glu Ile Ala Glu Lys Val Gly Phe 
    210                 215                 220                 

Glu Asp Met Asn Tyr Phe Thr Gln Arg Phe Lys Gln Ile Ala Gly Val 
225                 230                 235                 240 

Thr Pro Arg Gln Phe Lys Lys Gly Glu Asp Arg 
                245                 250     

<210>   1229
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1229
ttggacggtg cttggcgtgt catcattgga aaagttagac caggttcgga gtcagctctt   60
gtggaccttg cttggggcca gtgtcacatc tcttcttgtc tgtctctgct tagtgtggtt   120
cagtct                                                              126

<210>   1230
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1230
Met Asp Gly Ala Trp Arg Val Ile Ile Gly Lys Val Arg Pro Gly Ser 
1               5                   10                  15      

Glu Ser Ala Leu Val Asp Leu Ala Trp Gly Gln Cys His Ile Ser Ser 
            20                  25                  30          

Cys Leu Ser Leu Leu Ser Val Val Gln Ser 
        35                  40          

<210>   1231
<211>   1689
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1231
atgaagcgtt cttctctttt agttagaatg gttatttcca tctttctggt ctttctcatt   60
ctcctagctc tggttggaac tttctactat caatcaagtt cttcagccat tgaggccacc   120
attgagggca acagccaaac gaccatcagc cagactagcc actttattca gtcttatatc   180
aaaaaactag aaaccacctc gactggtttg acccagcaga cggatgttct ggcctatgct   240
gagaatccca gtcaagacaa ggtcgaggga atccgagatt tgtttttgac catcttgaag   300
tcagataagg acttgaaaac tgttgtgctg gtgaccaaat ctggtcaggt catttctaca   360
gatgacagtg tgcagatgaa aacttcctct gatatgatgg ctgaggattg gtaccaaaag   420
gccattcatc agggagctat gcctgttttg actccagctc gtaaatcaga tagtcagtgg   480
gtcatttctg tcactcaaga acttgttgat gcaaagggag ccaatcttgg tgtgcttcgt   540
ttggatattt cttatgaaac tctggaagcc tatctcaatc aactccagtt ggggcagcag   600
ggctttgcct tcattatcaa tgaaaaccat gaatttgtct accatcctca acacacagtt   660
tatagttcgt ctagcaaaat ggaggctatg aaaccctaca tcgatacagg tcagggttat   720
actcctggtc acaaatccta cgtcagtcaa gagaagattg caggaactga ttggacggtg   780
cttggcgtgt catcattgga aaagttagac caggttcgga gtcagctctt gtggaccttg   840
cttggggcca gtgtcacatc tcttcttgtc tgtctctgct tagtgtggtt cagtcttaaa   900
cgctggattg ctcctttgaa ggatttgaga gaaaccatgt tggaaattgc ttctggtgct   960
caaaatcttc gtgccaagga agttggtgcc tatgaactga gagaagtaac tcgccaattt   1020
aatgctatgt tggatcagat tgatcagttg atggtagcta ttcgtagcca ggaagaaacg   1080
acccgtcagt accaacttca agccctttcg agccagatta atccacattt cctctataac   1140
actttggaca ccatcatctg gatggctgaa tttcatgata gtcagcgagt ggtgcaggtg   1200
accaagtcct tggcaaccta tttccgcttg gcgctcaatc aaggcaagga cttgatttgt   1260
ctctctgacg aaatcaatca tgtccgccag tatctcttta tccagaaaca acgctatgga   1320
gataagctgg aatacgaaat taatgaaaat gttgcctttg ataatttagt cttacccaag   1380
ctggtcctac aaccccttgt agaaaatgct ctttaccatg gcattaagga aaaggaaggt   1440
cagggccata ttaaactttc tgtccagaaa caggattcgg gattggtcat ccgtattgag   1500
gatgatggcg ttggcttcca agatgctggt gatagtagtc aaagtcaact caaacgtggg   1560
ggagttggtc ttcaaaatgt cgatcaacgg ctcaaacttc attttggagc caattaccat   1620
atgaagattg attctagacc ccaaaaaggg acgaaagttg aaatatatat aaatagaata   1680
gaaactagc                                                           1689

<210>   1232
<211>   563
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902623 (0.E+01)

<400>   1232
Met Lys Arg Ser Ser Leu Leu Val Arg Met Val Ile Ser Ile Phe Leu 
1               5                   10                  15      

Val Phe Leu Ile Leu Leu Ala Leu Val Gly Thr Phe Tyr Tyr Gln Ser 
            20                  25                  30          

Ser Ser Ser Ala Ile Glu Ala Thr Ile Glu Gly Asn Ser Gln Thr Thr 
        35                  40                  45              

Ile Ser Gln Thr Ser His Phe Ile Gln Ser Tyr Ile Lys Lys Leu Glu 
    50                  55                  60                  

Thr Thr Ser Thr Gly Leu Thr Gln Gln Thr Asp Val Leu Ala Tyr Ala 
65                  70                  75                  80  

Glu Asn Pro Ser Gln Asp Lys Val Glu Gly Ile Arg Asp Leu Phe Leu 
                85                  90                  95      

Thr Ile Leu Lys Ser Asp Lys Asp Leu Lys Thr Val Val Leu Val Thr 
            100                 105                 110         

Lys Ser Gly Gln Val Ile Ser Thr Asp Asp Ser Val Gln Met Lys Thr 
        115                 120                 125             

Ser Ser Asp Met Met Ala Glu Asp Trp Tyr Gln Lys Ala Ile His Gln 
    130                 135                 140                 

Gly Ala Met Pro Val Leu Thr Pro Ala Arg Lys Ser Asp Ser Gln Trp 
145                 150                 155                 160 

Val Ile Ser Val Thr Gln Glu Leu Val Asp Ala Lys Gly Ala Asn Leu 
                165                 170                 175     

Gly Val Leu Arg Leu Asp Ile Ser Tyr Glu Thr Leu Glu Ala Tyr Leu 
            180                 185                 190         

Asn Gln Leu Gln Leu Gly Gln Gln Gly Phe Ala Phe Ile Ile Asn Glu 
        195                 200                 205             

Asn His Glu Phe Val Tyr His Pro Gln His Thr Val Tyr Ser Ser Ser 
    210                 215                 220                 

Ser Lys Met Glu Ala Met Lys Pro Tyr Ile Asp Thr Gly Gln Gly Tyr 
225                 230                 235                 240 

Thr Pro Gly His Lys Ser Tyr Val Ser Gln Glu Lys Ile Ala Gly Thr 
                245                 250                 255     

Asp Trp Thr Val Leu Gly Val Ser Ser Leu Glu Lys Leu Asp Gln Val 
            260                 265                 270         

Arg Ser Gln Leu Leu Trp Thr Leu Leu Gly Ala Ser Val Thr Ser Leu 
        275                 280                 285             

Leu Val Cys Leu Cys Leu Val Trp Phe Ser Leu Lys Arg Trp Ile Ala 
    290                 295                 300                 

Pro Leu Lys Asp Leu Arg Glu Thr Met Leu Glu Ile Ala Ser Gly Ala 
305                 310                 315                 320 

Gln Asn Leu Arg Ala Lys Glu Val Gly Ala Tyr Glu Leu Arg Glu Val 
                325                 330                 335     

Thr Arg Gln Phe Asn Ala Met Leu Asp Gln Ile Asp Gln Leu Met Val 
            340                 345                 350         

Ala Ile Arg Ser Gln Glu Glu Thr Thr Arg Gln Tyr Gln Leu Gln Ala 
        355                 360                 365             

Leu Ser Ser Gln Ile Asn Pro His Phe Leu Tyr Asn Thr Leu Asp Thr 
    370                 375                 380                 

Ile Ile Trp Met Ala Glu Phe His Asp Ser Gln Arg Val Val Gln Val 
385                 390                 395                 400 

Thr Lys Ser Leu Ala Thr Tyr Phe Arg Leu Ala Leu Asn Gln Gly Lys 
                405                 410                 415     

Asp Leu Ile Cys Leu Ser Asp Glu Ile Asn His Val Arg Gln Tyr Leu 
            420                 425                 430         

Phe Ile Gln Lys Gln Arg Tyr Gly Asp Lys Leu Glu Tyr Glu Ile Asn 
        435                 440                 445             

Glu Asn Val Ala Phe Asp Asn Leu Val Leu Pro Lys Leu Val Leu Gln 
    450                 455                 460                 

Pro Leu Val Glu Asn Ala Leu Tyr His Gly Ile Lys Glu Lys Glu Gly 
465                 470                 475                 480 

Gln Gly His Ile Lys Leu Ser Val Gln Lys Gln Asp Ser Gly Leu Val 
                485                 490                 495     

Ile Arg Ile Glu Asp Asp Gly Val Gly Phe Gln Asp Ala Gly Asp Ser 
            500                 505                 510         

Ser Gln Ser Gln Leu Lys Arg Gly Gly Val Gly Leu Gln Asn Val Asp 
        515                 520                 525             

Gln Arg Leu Lys Leu His Phe Gly Ala Asn Tyr His Met Lys Ile Asp 
    530                 535                 540                 

Ser Arg Pro Gln Lys Gly Thr Lys Val Glu Ile Tyr Ile Asn Arg Ile 
545                 550                 555                 560 

Glu Thr Ser 
            

<210>   1233
<211>   561
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1233
atgaacgaga cacagattca aagagaaaca cgtcaggtag tggaagatgt tttagaaaag   60
accaatttga agcagggggc cctttttgtt ttaggtctat cttctagtga ggtgctaggt   120
ggtcatattg ggaaagaatc cagtcaagag attggtgagc tgatagtgga gactatcttg   180
gatattctag gtagtagagg tatccattta gcagttcaag gttgtgagca tgtcaatcgg   240
gctctcgttg ttgaacgtca ggtggcagag cagtttggtc tggaaattgt cagtgtccat   300
cctactcttc atgcaggagg ttcggggcag ttggcagcct ttaagtttat gcaggatcca   360
gttgaggttg aatttatcaa ggctcatgct ggattggata tcggagacac tgcaattggc   420
atgcatgtca agcatgttca ggttccgatt cgccctattt tgagagagat tggtcatgcc   480
catgtaacgg cactggctag tcgtccaaaa ttaatcggag gtgcgcgtgc gcactatccg   540
caagatgcta ttaggaagtt t                                             561

<210>   1234
<211>   187
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902624 (e-101)

<400>   1234
Met Asn Glu Thr Gln Ile Gln Arg Glu Thr Arg Gln Val Val Glu Asp 
1               5                   10                  15      

Val Leu Glu Lys Thr Asn Leu Lys Gln Gly Ala Leu Phe Val Leu Gly 
            20                  25                  30          

Leu Ser Ser Ser Glu Val Leu Gly Gly His Ile Gly Lys Glu Ser Ser 
        35                  40                  45              

Gln Glu Ile Gly Glu Leu Ile Val Glu Thr Ile Leu Asp Ile Leu Gly 
    50                  55                  60                  

Ser Arg Gly Ile His Leu Ala Val Gln Gly Cys Glu His Val Asn Arg 
65                  70                  75                  80  

Ala Leu Val Val Glu Arg Gln Val Ala Glu Gln Phe Gly Leu Glu Ile 
                85                  90                  95      

Val Ser Val His Pro Thr Leu His Ala Gly Gly Ser Gly Gln Leu Ala 
            100                 105                 110         

Ala Phe Lys Phe Met Gln Asp Pro Val Glu Val Glu Phe Ile Lys Ala 
        115                 120                 125             

His Ala Gly Leu Asp Ile Gly Asp Thr Ala Ile Gly Met His Val Lys 
    130                 135                 140                 

His Val Gln Val Pro Ile Arg Pro Ile Leu Arg Glu Ile Gly His Ala 
145                 150                 155                 160 

His Val Thr Ala Leu Ala Ser Arg Pro Lys Leu Ile Gly Gly Ala Arg 
                165                 170                 175     

Ala His Tyr Pro Gln Asp Ala Ile Arg Lys Phe 
            180                 185         

<210>   1235
<211>   5643
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1235
atggctcctt ctgtagtgga cgcagccacc tatcactatg taaataaaga gattatttca   60
caagaagcta aagatttaat tcagacagga aagcctgaca ggaatgaagt tgtatatggt   120
ttggtgtatc aaaaagatca gttgcctcaa acagggacag aagcatctgt tttgacagct   180
tttggtttgc tgactgttgg gagcttgctt ttaatctaca agagaaagaa aattgctagc   240
gtctttctag ttggagctat gggattggta gttcttccta gtgcaggggc tgtagaccca   300
gttgcgaccc tagcgctggc tagtcgagag ggtgttgttg aaatggaggg ctatcgctat   360
gttggttatc tatcaggtga catcctcaaa acgcttggct tggacactgt tttagaagaa   420
acctcagcaa aacctggaga ggtgactgtg gtcgaagttg agactcctca atcaataaca   480
aatcaggagc aagctaggac agaaaaccaa gtagtagaga cagaggaagc tccaaaagaa   540
gaagcaccta aaacagaaga aagtccaaag gaagaaccaa aatcggaggt aaaacctact   600
gacgacaccc ttcctaaagt agaagagggg aaagaagatt cagcagaacc agctccagtt   660
gaagaagtag gtggagaagt tgagtcaaaa ccagaggaaa aagtagcagt taagccagaa   720
agtcaaccat cagacaaacc agctgaggaa tcaaaagttg aacaagcagg tgaaccagtc   780
gcgccaagag aagacgaaaa ggcaccagtc gagccagaaa agcaaccaga agctcctgaa   840
gaagagaagg ctgtagagga aacaccgaaa caagaagagt caactccaga taccaaggct   900
gaagaaactg tagaaccaaa agaggagact gttaatcaat ctattgaaca accaaaagtt   960
gaaacgcctg ctgtagaaaa acaaacagaa ccaacagagg aaccaaaagt tgaacaagca   1020
ggtgaaccag tcgcgccaag agaagacgaa caggcaccaa cggcaccagt tgagccagaa   1080
aagcaaccag aagttcctga agaagagaag gctgtagagg aaacaccgaa accagaagat   1140
aaaataaagg gtattggtac taaagaacca gttgataaaa gtgagttaaa taatcaaatt   1200
gataaagcta gttcagtttc tcctactgat tattctacag caagttacaa tgctcttgga   1260
cctgttttag aaactgcaaa aggtgtctat gcttcagagc ctgtaaaaca gcctgaggta   1320
aatagcgaga caaataaact taaaacggct attgacgctc taaacgttga taaaactgaa   1380
ttaaacaata cgattgcaga tgcaaaaaca aaggtaaaag aacattacag tgatagaagt   1440
tggcaaaacc tccaaactga agttacaaag gctgaaaaag ttgcagctaa tacagatgct   1500
aaacaaagtg aagttaacga agctgttgaa aaattaactg caactattga aaaattggtt   1560
gaattatctg aaaagccaat attaacattg actagtaccg ataagaaaat attggaacgt   1620
gaagctgttg ctaagtatac tctagaaaat caaaacaaaa caaaaatcaa atcaatcaca   1680
gctgaattga aaaaaggaga agaagttatt aatactgtag tccttacaga tgacaaggta   1740
acaacagaaa ctataagcgc tgcatttaag aacctagagt actacaaaga atacacccta   1800
tctacaacta tgatttacga cagaggtaac ggtgaagaaa ctgaaactct agaaaatcaa   1860
aatattcaat tagatcttaa aaaagttgag cttaaaaata ttaaacgtac agatttaatc   1920
aaatacgaaa atggaaaaga aactaatgaa tcactgataa caactattcc tgatgataag   1980
agcaattatt atttaaaaat aacttcaaat aatcagaaaa ctacattact agctgttaaa   2040
aatatagaag aaactacggt taacggaaca cctgtatata aagttacagc aatcgcagac   2100
aatttagtct ctagaactgc tgataataaa tttgaagaag aatacgttca ctatattgaa   2160
aaacctaaag tccacgaaga taatgtatat tataatttca aagaattagt ggaagctatt   2220
caaaacgatc cttcaaaaga atatcgtctg ggacaatcaa tgagcgctag aaatgttgtt   2280
cctaatggaa aatcatatat cactaaagaa ttcacaggaa aacttttaag ttctgaagga   2340
aaacaatttg ctattactga attggaacat ccattattta atgtgataac aaacgcaacg   2400
ataaataatg tgaattttga aaatgtagag atagaacgtt ctggtcaaga taatattgca   2460
tcattagcca atactatgaa aggttcttca gttattacaa atgtcaaaat tacaggcaca   2520
ctttcaggtc gtaataatgt tgctggattt gtaaataata tgaatgatgg aactcgtatt   2580
gaaaatgttg ctttctttgg caaactacac tctacaagtg gaaatggctc tcatacaggg   2640
ggaattgcag gtacaaacta tagaggaatt gttagaaaag catatgttga tgctactatt   2700
acaggaaaca aaacacgcgc cagcttgtta gttcctaaag tagattatgg attaactcta   2760
gaccatctta ttggtacaaa agctctccta actgagtcgg ttgtaaaagg taaaatagat   2820
gtttcaaatc cagtagaagt tggagcaata gcaagtaaga cttggcctgt aggtacggta   2880
agtaattctg tcagctatgc taagattatc cgtggagagg agttattcgg ctctaacgac   2940
gttgatgatt ctgattatgc tagtgctcat ataaaagatt tatatgcggt agagggatat   3000
tcgtcaggta atagatcatt taggaaatct aaaacattta ctaaattaac taaagaacaa   3060
gctgatgcta aagttactac tttcaatatt actgctgata aattagaaag tgatctatct   3120
cctcttgcaa aacttaatga agaaaaagcc tattctagta ttcaagatta taacgctgaa   3180
tataaccaag cctataaaaa tcttgaaaaa ttaataccat tctacaataa agattatatt   3240
gtatatcaag gtaataaatt aaataaagaa caccatctaa atactaaaga agttctttct   3300
gttaccgcga tgaacaacaa tgagtttatc acaaacctag atgaagctaa taaaattatt   3360
gttcactatg cggacggtac aaaagattac tttaacttgt cttctagcag tgaaggttta   3420
agtaatgtaa aagaatatac tataactgac ttaggaatta aatatacacc taatatcgtt   3480
caaaaagata acactactct tgttaatgat ataaaatcta ttttagaatc agtagagctt   3540
cagtctcaaa cgatgtatca gcatctaaat cgattaggtg actatagagt taatgcaatc   3600
aaagatttat atttagaaga aagcttcaca gatgttaaag aaaacttaac aaacctaatc   3660
acaaaattag ttcaaaacga agaacatcaa ctaaatgatt ctccagctgc tcgtcaaatg   3720
attcgtgata aagtcgagaa aaacaaagca gctttattac taggtttaac ttacctaaat   3780
cgttactatg gagttaaatt tggtgatgtt aatattaaag aattaatgct attcaaacca   3840

gatttctatg gtgaaaaagt tagcgtatta gacagattaa ttgaaatcgg ttctaaagag   3900
aacaacatta aaggttcacg tacattcgac gcattcggtc aagtattggc taaatatact   3960
aaatcaggta atttagatgc atttttaaat tataatagac aattgttcac aaatatagac   4020
aatatgaacg attggtttat tgatgctaca gaagaccatg tctacatcgc agaacgcgct   4080
tctgaggtcg aagaaattaa aaattctaaa catcgtgcat tcgataattt aaaacgaagt   4140
caccttagaa atactatact cccactactg aatattgata aagcacatct ttatttaatt   4200
tcaaattata atgcaattgc ctttggtagt gcagagcgat taggtaaaaa atcattagaa   4260
gatattaaag atatcgttaa caaagctgca gatggttata gaaactatta tgatttctgg   4320
tatcgtctag cgtctgataa cgttaaacaa cgactactaa gagatgctgt tattcctatt   4380
tgggaaggtt ataacgctcc tggtggatgg gttgaaaaat atggccgcta taataccgac   4440
aaagtatata ctcctcttag agaattcttt ggtcctatgg ataagtatta taattataat   4500
ggaacaggag cttatgctgc tatatatcct aactctgatg atattagaac tgatgtaaaa   4560
tatgttcatt tagaaatggt tggtgaatac ggtatttcag tttacacaca tgaaacaaca   4620
cacgtcaacg accgtgcgat ttacttaggt ggctttggac accgtgaagg tactgatgct   4680
gaagcatatg ctcagggtat gctacaaact cctgttactg gtagtggatt tgatgagttt   4740
ggttctttag gtattaatat ggtatttaaa cgcaaaaatg atgggaatca gtggtatatt   4800
acagatccaa aaactctaaa aacacgagaa gatattaata gatatatgaa gggttataat   4860
gacactttaa ctcttcttga tgaaattgag gctgaatctg tgatttctca acaaaataaa   4920
gatttaaata gtgcatggtt caaaaaaata gatagagaat accgtgataa caataaatta   4980
aatcaatggg ataaaattcg aaatctaagt caagaagaga aaaatgaatt aaatattcaa   5040
tctgttaatg atttagttga tcaacaatta atgactaatc gcaatccagg taatggtatc   5100
tataaacccg aagcaattag ctataacgat caatcacctt atgtaggtgt tagaatgatg   5160
accggtatct acggaggtaa tactagtaaa ggtgctcctg gagctgtttc attcaaacat   5220
aatgctttta gattatgggg ttactacgga tacgaaaatg ggttcttagg ttatgcttca   5280
aataaatata aacaacaatc taaaacagat ggtgagtctg ttctaagtga tgaatatatt   5340
atcaagaaaa tatctaacaa tacatttaat actattgaag aatttaaaaa agcttacttc   5400
aaagaagtta aagataaagc aacgaaagga ttaacaacat tcgaagtaaa tggttcttcc   5460
gtttcatcat acgatgattt actgacattg tttaaagaag ctgttaaaaa agatgccgaa   5520
actcttaaac aagaagcaaa cggtaataaa acagtatcta tgaataatac agttaaatta   5580
aaagaagctg tttataagaa acttcttcaa caaacaaata gctttaaaac ttcaatcttt   5640
aaa                                                                 5643

<210>   1236
<211>   1881
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   zinc metalloprotease ZmpB, putative
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15902625 (0.E+01)

<400>   1236
Met Ala Pro Ser Val Val Asp Ala Ala Thr Tyr His Tyr Val Asn Lys 
1               5                   10                  15      

Glu Ile Ile Ser Gln Glu Ala Lys Asp Leu Ile Gln Thr Gly Lys Pro 
            20                  25                  30          

Asp Arg Asn Glu Val Val Tyr Gly Leu Val Tyr Gln Lys Asp Gln Leu 
        35                  40                  45              

Pro Gln Thr Gly Thr Glu Ala Ser Val Leu Thr Ala Phe Gly Leu Leu 
    50                  55                  60                  

Thr Val Gly Ser Leu Leu Leu Ile Tyr Lys Arg Lys Lys Ile Ala Ser 
65                  70                  75                  80  

Val Phe Leu Val Gly Ala Met Gly Leu Val Val Leu Pro Ser Ala Gly 
                85                  90                  95      

Ala Val Asp Pro Val Ala Thr Leu Ala Leu Ala Ser Arg Glu Gly Val 
            100                 105                 110         

Val Glu Met Glu Gly Tyr Arg Tyr Val Gly Tyr Leu Ser Gly Asp Ile 
        115                 120                 125             

Leu Lys Thr Leu Gly Leu Asp Thr Val Leu Glu Glu Thr Ser Ala Lys 
    130                 135                 140                 

Pro Gly Glu Val Thr Val Val Glu Val Glu Thr Pro Gln Ser Ile Thr 
145                 150                 155                 160 

Asn Gln Glu Gln Ala Arg Thr Glu Asn Gln Val Val Glu Thr Glu Glu 
                165                 170                 175     

Ala Pro Lys Glu Glu Ala Pro Lys Thr Glu Glu Ser Pro Lys Glu Glu 
            180                 185                 190         

Pro Lys Ser Glu Val Lys Pro Thr Asp Asp Thr Leu Pro Lys Val Glu 
        195                 200                 205             

Glu Gly Lys Glu Asp Ser Ala Glu Pro Ala Pro Val Glu Glu Val Gly 
    210                 215                 220                 

Gly Glu Val Glu Ser Lys Pro Glu Glu Lys Val Ala Val Lys Pro Glu 
225                 230                 235                 240 

Ser Gln Pro Ser Asp Lys Pro Ala Glu Glu Ser Lys Val Glu Gln Ala 
                245                 250                 255     

Gly Glu Pro Val Ala Pro Arg Glu Asp Glu Lys Ala Pro Val Glu Pro 
            260                 265                 270         

Glu Lys Gln Pro Glu Ala Pro Glu Glu Glu Lys Ala Val Glu Glu Thr 
        275                 280                 285             

Pro Lys Gln Glu Glu Ser Thr Pro Asp Thr Lys Ala Glu Glu Thr Val 
    290                 295                 300                 

Glu Pro Lys Glu Glu Thr Val Asn Gln Ser Ile Glu Gln Pro Lys Val 
305                 310                 315                 320 

Glu Thr Pro Ala Val Glu Lys Gln Thr Glu Pro Thr Glu Glu Pro Lys 
                325                 330                 335     

Val Glu Gln Ala Gly Glu Pro Val Ala Pro Arg Glu Asp Glu Gln Ala 
            340                 345                 350         

Pro Thr Ala Pro Val Glu Pro Glu Lys Gln Pro Glu Val Pro Glu Glu 
        355                 360                 365             

Glu Lys Ala Val Glu Glu Thr Pro Lys Pro Glu Asp Lys Ile Lys Gly 
    370                 375                 380                 

Ile Gly Thr Lys Glu Pro Val Asp Lys Ser Glu Leu Asn Asn Gln Ile 
385                 390                 395                 400 

Asp Lys Ala Ser Ser Val Ser Pro Thr Asp Tyr Ser Thr Ala Ser Tyr 
                405                 410                 415     

Asn Ala Leu Gly Pro Val Leu Glu Thr Ala Lys Gly Val Tyr Ala Ser 
            420                 425                 430         

Glu Pro Val Lys Gln Pro Glu Val Asn Ser Glu Thr Asn Lys Leu Lys 
        435                 440                 445             

Thr Ala Ile Asp Ala Leu Asn Val Asp Lys Thr Glu Leu Asn Asn Thr 
    450                 455                 460                 

Ile Ala Asp Ala Lys Thr Lys Val Lys Glu His Tyr Ser Asp Arg Ser 
465                 470                 475                 480 

Trp Gln Asn Leu Gln Thr Glu Val Thr Lys Ala Glu Lys Val Ala Ala 
                485                 490                 495     

Asn Thr Asp Ala Lys Gln Ser Glu Val Asn Glu Ala Val Glu Lys Leu 
            500                 505                 510         

Thr Ala Thr Ile Glu Lys Leu Val Glu Leu Ser Glu Lys Pro Ile Leu 
        515                 520                 525             

Thr Leu Thr Ser Thr Asp Lys Lys Ile Leu Glu Arg Glu Ala Val Ala 
    530                 535                 540                 

Lys Tyr Thr Leu Glu Asn Gln Asn Lys Thr Lys Ile Lys Ser Ile Thr 
545                 550                 555                 560 

Ala Glu Leu Lys Lys Gly Glu Glu Val Ile Asn Thr Val Val Leu Thr 
                565                 570                 575     

Asp Asp Lys Val Thr Thr Glu Thr Ile Ser Ala Ala Phe Lys Asn Leu 
            580                 585                 590         

Glu Tyr Tyr Lys Glu Tyr Thr Leu Ser Thr Thr Met Ile Tyr Asp Arg 
        595                 600                 605             

Gly Asn Gly Glu Glu Thr Glu Thr Leu Glu Asn Gln Asn Ile Gln Leu 
    610                 615                 620                 

Asp Leu Lys Lys Val Glu Leu Lys Asn Ile Lys Arg Thr Asp Leu Ile 
625                 630                 635                 640 

Lys Tyr Glu Asn Gly Lys Glu Thr Asn Glu Ser Leu Ile Thr Thr Ile 
                645                 650                 655     

Pro Asp Asp Lys Ser Asn Tyr Tyr Leu Lys Ile Thr Ser Asn Asn Gln 
            660                 665                 670         

Lys Thr Thr Leu Leu Ala Val Lys Asn Ile Glu Glu Thr Thr Val Asn 
        675                 680                 685             

Gly Thr Pro Val Tyr Lys Val Thr Ala Ile Ala Asp Asn Leu Val Ser 
    690                 695                 700                 

Arg Thr Ala Asp Asn Lys Phe Glu Glu Glu Tyr Val His Tyr Ile Glu 
705                 710                 715                 720 

Lys Pro Lys Val His Glu Asp Asn Val Tyr Tyr Asn Phe Lys Glu Leu 
                725                 730                 735     

Val Glu Ala Ile Gln Asn Asp Pro Ser Lys Glu Tyr Arg Leu Gly Gln 
            740                 745                 750         

Ser Met Ser Ala Arg Asn Val Val Pro Asn Gly Lys Ser Tyr Ile Thr 
        755                 760                 765             

Lys Glu Phe Thr Gly Lys Leu Leu Ser Ser Glu Gly Lys Gln Phe Ala 
    770                 775                 780                 

Ile Thr Glu Leu Glu His Pro Leu Phe Asn Val Ile Thr Asn Ala Thr 
785                 790                 795                 800 

Ile Asn Asn Val Asn Phe Glu Asn Val Glu Ile Glu Arg Ser Gly Gln 
                805                 810                 815     

Asp Asn Ile Ala Ser Leu Ala Asn Thr Met Lys Gly Ser Ser Val Ile 
            820                 825                 830         

Thr Asn Val Lys Ile Thr Gly Thr Leu Ser Gly Arg Asn Asn Val Ala 
        835                 840                 845             

Gly Phe Val Asn Asn Met Asn Asp Gly Thr Arg Ile Glu Asn Val Ala 
    850                 855                 860                 

Phe Phe Gly Lys Leu His Ser Thr Ser Gly Asn Gly Ser His Thr Gly 
865                 870                 875                 880 

Gly Ile Ala Gly Thr Asn Tyr Arg Gly Ile Val Arg Lys Ala Tyr Val 
                885                 890                 895     

Asp Ala Thr Ile Thr Gly Asn Lys Thr Arg Ala Ser Leu Leu Val Pro 
            900                 905                 910         

Lys Val Asp Tyr Gly Leu Thr Leu Asp His Leu Ile Gly Thr Lys Ala 
        915                 920                 925             

Leu Leu Thr Glu Ser Val Val Lys Gly Lys Ile Asp Val Ser Asn Pro 
    930                 935                 940                 

Val Glu Val Gly Ala Ile Ala Ser Lys Thr Trp Pro Val Gly Thr Val 
945                 950                 955                 960 

Ser Asn Ser Val Ser Tyr Ala Lys Ile Ile Arg Gly Glu Glu Leu Phe 
                965                 970                 975     

Gly Ser Asn Asp Val Asp Asp Ser Asp Tyr Ala Ser Ala His Ile Lys 
            980                 985                 990         

Asp Leu Tyr Ala Val Glu Gly Tyr Ser Ser Gly Asn Arg Ser Phe Arg 
        995                 1000                1005            

Lys Ser Lys Thr Phe Thr Lys Leu Thr Lys Glu Gln Ala Asp Ala Lys 
    1010                1015                1020                

Val Thr Thr Phe Asn Ile Thr Ala Asp Lys Leu Glu Ser Asp Leu Ser 
1025                1030                1035                1040

Pro Leu Ala Lys Leu Asn Glu Glu Lys Ala Tyr Ser Ser Ile Gln Asp 
                1045                1050                1055    

Tyr Asn Ala Glu Tyr Asn Gln Ala Tyr Lys Asn Leu Glu Lys Leu Ile 
            1060                1065                1070        

Pro Phe Tyr Asn Lys Asp Tyr Ile Val Tyr Gln Gly Asn Lys Leu Asn 
        1075                1080                1085            

Lys Glu His His Leu Asn Thr Lys Glu Val Leu Ser Val Thr Ala Met 
    1090                1095                1100                

Asn Asn Asn Glu Phe Ile Thr Asn Leu Asp Glu Ala Asn Lys Ile Ile 
1105                1110                1115                1120

Val His Tyr Ala Asp Gly Thr Lys Asp Tyr Phe Asn Leu Ser Ser Ser 
                1125                1130                1135    

Ser Glu Gly Leu Ser Asn Val Lys Glu Tyr Thr Ile Thr Asp Leu Gly 
            1140                1145                1150        

Ile Lys Tyr Thr Pro Asn Ile Val Gln Lys Asp Asn Thr Thr Leu Val 
        1155                1160                1165            

Asn Asp Ile Lys Ser Ile Leu Glu Ser Val Glu Leu Gln Ser Gln Thr 
    1170                1175                1180                

Met Tyr Gln His Leu Asn Arg Leu Gly Asp Tyr Arg Val Asn Ala Ile 
1185                1190                1195                1200

Lys Asp Leu Tyr Leu Glu Glu Ser Phe Thr Asp Val Lys Glu Asn Leu 
                1205                1210                1215    

Thr Asn Leu Ile Thr Lys Leu Val Gln Asn Glu Glu His Gln Leu Asn 
            1220                1225                1230        

Asp Ser Pro Ala Ala Arg Gln Met Ile Arg Asp Lys Val Glu Lys Asn 
        1235                1240                1245            

Lys Ala Ala Leu Leu Leu Gly Leu Thr Tyr Leu Asn Arg Tyr Tyr Gly 
    1250                1255                1260                

Val Lys Phe Gly Asp Val Asn Ile Lys Glu Leu Met Leu Phe Lys Pro 
1265                1270                1275                1280

Asp Phe Tyr Gly Glu Lys Val Ser Val Leu Asp Arg Leu Ile Glu Ile 
                1285                1290                1295    

Gly Ser Lys Glu Asn Asn Ile Lys Gly Ser Arg Thr Phe Asp Ala Phe 
            1300                1305                1310        

Gly Gln Val Leu Ala Lys Tyr Thr Lys Ser Gly Asn Leu Asp Ala Phe 
        1315                1320                1325            

Leu Asn Tyr Asn Arg Gln Leu Phe Thr Asn Ile Asp Asn Met Asn Asp 
    1330                1335                1340                

Trp Phe Ile Asp Ala Thr Glu Asp His Val Tyr Ile Ala Glu Arg Ala 
1345                1350                1355                1360

Ser Glu Val Glu Glu Ile Lys Asn Ser Lys His Arg Ala Phe Asp Asn 
                1365                1370                1375    

Leu Lys Arg Ser His Leu Arg Asn Thr Ile Leu Pro Leu Leu Asn Ile 
            1380                1385                1390        

Asp Lys Ala His Leu Tyr Leu Ile Ser Asn Tyr Asn Ala Ile Ala Phe 
        1395                1400                1405            

Gly Ser Ala Glu Arg Leu Gly Lys Lys Ser Leu Glu Asp Ile Lys Asp 
    1410                1415                1420                

Ile Val Asn Lys Ala Ala Asp Gly Tyr Arg Asn Tyr Tyr Asp Phe Trp 
1425                1430                1435                1440

Tyr Arg Leu Ala Ser Asp Asn Val Lys Gln Arg Leu Leu Arg Asp Ala 
                1445                1450                1455    

Val Ile Pro Ile Trp Glu Gly Tyr Asn Ala Pro Gly Gly Trp Val Glu 
            1460                1465                1470        

Lys Tyr Gly Arg Tyr Asn Thr Asp Lys Val Tyr Thr Pro Leu Arg Glu 
        1475                1480                1485            

Phe Phe Gly Pro Met Asp Lys Tyr Tyr Asn Tyr Asn Gly Thr Gly Ala 
    1490                1495                1500                

Tyr Ala Ala Ile Tyr Pro Asn Ser Asp Asp Ile Arg Thr Asp Val Lys 
1505                1510                1515                1520

Tyr Val His Leu Glu Met Val Gly Glu Tyr Gly Ile Ser Val Tyr Thr 
                1525                1530                1535    

His Glu Thr Thr His Val Asn Asp Arg Ala Ile Tyr Leu Gly Gly Phe 
            1540                1545                1550        

Gly His Arg Glu Gly Thr Asp Ala Glu Ala Tyr Ala Gln Gly Met Leu 
        1555                1560                1565            

Gln Thr Pro Val Thr Gly Ser Gly Phe Asp Glu Phe Gly Ser Leu Gly 
    1570                1575                1580                

Ile Asn Met Val Phe Lys Arg Lys Asn Asp Gly Asn Gln Trp Tyr Ile 
1585                1590                1595                1600

Thr Asp Pro Lys Thr Leu Lys Thr Arg Glu Asp Ile Asn Arg Tyr Met 
                1605                1610                1615    

Lys Gly Tyr Asn Asp Thr Leu Thr Leu Leu Asp Glu Ile Glu Ala Glu 
            1620                1625                1630        

Ser Val Ile Ser Gln Gln Asn Lys Asp Leu Asn Ser Ala Trp Phe Lys 
        1635                1640                1645            

Lys Ile Asp Arg Glu Tyr Arg Asp Asn Asn Lys Leu Asn Gln Trp Asp 
    1650                1655                1660                

Lys Ile Arg Asn Leu Ser Gln Glu Glu Lys Asn Glu Leu Asn Ile Gln 
1665                1670                1675                1680

Ser Val Asn Asp Leu Val Asp Gln Gln Leu Met Thr Asn Arg Asn Pro 
                1685                1690                1695    

Gly Asn Gly Ile Tyr Lys Pro Glu Ala Ile Ser Tyr Asn Asp Gln Ser 
            1700                1705                1710        

Pro Tyr Val Gly Val Arg Met Met Thr Gly Ile Tyr Gly Gly Asn Thr 
        1715                1720                1725            

Ser Lys Gly Ala Pro Gly Ala Val Ser Phe Lys His Asn Ala Phe Arg 
    1730                1735                1740                

Leu Trp Gly Tyr Tyr Gly Tyr Glu Asn Gly Phe Leu Gly Tyr Ala Ser 
1745                1750                1755                1760

Asn Lys Tyr Lys Gln Gln Ser Lys Thr Asp Gly Glu Ser Val Leu Ser 
                1765                1770                1775    

Asp Glu Tyr Ile Ile Lys Lys Ile Ser Asn Asn Thr Phe Asn Thr Ile 
            1780                1785                1790        

Glu Glu Phe Lys Lys Ala Tyr Phe Lys Glu Val Lys Asp Lys Ala Thr 
        1795                1800                1805            

Lys Gly Leu Thr Thr Phe Glu Val Asn Gly Ser Ser Val Ser Ser Tyr 
    1810                1815                1820                

Asp Asp Leu Leu Thr Leu Phe Lys Glu Ala Val Lys Lys Asp Ala Glu 
1825                1830                1835                1840

Thr Leu Lys Gln Glu Ala Asn Gly Asn Lys Thr Val Ser Met Asn Asn 
                1845                1850                1855    

Thr Val Lys Leu Lys Glu Ala Val Tyr Lys Lys Leu Leu Gln Gln Thr 
            1860                1865                1870        

Asn Ser Phe Lys Thr Ser Ile Phe Lys 
        1875                1880    

<210>   1237
<211>   1719
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1237
atgcatagaa aaacagtgat tgattttagg actttggggg agagatatac ctttacccag   60
cctattaaag agttgaaaac gagaaatgta gaagaagtgg cagatttgct ggcacaagtg   120
gaaagctacc aagagcaagg ttattatgtg gtggggtatg tcagctacga ggctgcacct   180
gcttttgagg aaaaattagc agttcacaag gatcccctac tgggagagta cctgctttac   240
tttactgttc atgatatcgt agaaacttcc cctattcctc tgacttatga ggatattgat   300
ttgccctcaa attggcagga agtaacgtct gcagcagact atgaaaaggc cattgcccaa   360
attcaccatc atttacggca gggagatacc tatcaggtca actacaccgt ccaacttaag   420
caaaagttaa atgccaatcc ttttgccatc tacaatcgta tggtggtaga gcaggaggcg   480
ggctacaatg cctatgtgga acatgacgag atgacagtga tttccatgag cccagagctc   540

ttttttgagc aaaatgatcg cgagttgaca acacgaccaa tgaaggggac gactcagcgt   600
ggggtaactg accaagaaga tcttgaacag gccagttggt tggaacagga tcccaaaaat   660
cgctctgaaa atatgatgat tgtggacctc ttgcgcaatg atatgaaccg tatttctgaa   720
gttgggagcg agcacgtgga gcgtctgtgt caggtagagc agtattcaac tgtttggcag   780
atgacttcga ccatcaagag tcagttgcga gaggatgtgg accttgttga aatcttccgc   840
tcactctttc cttgtggttc cataacgggt gcaccgaaaa ttgcgacaat ggagattatc   900
aaggacttgg agcctcaacc gcgtggagtc tactgtggaa cgattggtct cttgcttcca   960
aatggacgac ggatttttaa tgtggccatt cgtaccattc aacttcacaa aggtcaagcc   1020
atttatggag ttggcggagg gattacttgg gatagcacat gggaatctga ataccgagag   1080
gttcatcaaa aggcagcagt tctctatcgt aaacaagctc gcttccaatt aattacaact   1140
ggaaaaatca gccaaaaaca actgatgttt gaagaacaac atctggaaag gctgagaaaa   1200
gctagtcgtt attttgcttt tccttttgat gcagaagact tgggacacaa gattgaggaa   1260
gagtgtcagg attgtgaagc taatcgagat taccgcttgc gaatcagcct tagcaaatct   1320
ggagagatag aagtcaatcg tcaagtatta acccctctca gtacaagctt ttgtcaggcc   1380
caagtctgtc ttcaggaagc tgctttgaat caatccttta cctactttaa aaccactcac   1440
cgaccgcatt tgagcctagg agaacaagag aagatttacc acaataagtc aggagaactg   1500
cttgaaacct ctataggaaa tttggttctg aaaatcgctg gaaaactcta cacaccgcct   1560
atccgacttg gaatcttgcc aggaatttac cgtcagcatt tgctagaaac aggacaggta   1620
gaagagaaag tcttgacctt ggcagattta acccaagcag aagctattta cggctgtaat   1680
gcagtgagag gcttgtatga attaagcctt gaggagaac                          1719

<210>   1238
<211>   573
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   chorismate binding enzyme
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902626 (0.E+01)

<400>   1238
Met His Arg Lys Thr Val Ile Asp Phe Arg Thr Leu Gly Glu Arg Tyr 
1               5                   10                  15      

Thr Phe Thr Gln Pro Ile Lys Glu Leu Lys Thr Arg Asn Val Glu Glu 
            20                  25                  30          

Val Ala Asp Leu Leu Ala Gln Val Glu Ser Tyr Gln Glu Gln Gly Tyr 
        35                  40                  45              

Tyr Val Val Gly Tyr Val Ser Tyr Glu Ala Ala Pro Ala Phe Glu Glu 
    50                  55                  60                  

Lys Leu Ala Val His Lys Asp Pro Leu Leu Gly Glu Tyr Leu Leu Tyr 
65                  70                  75                  80  

Phe Thr Val His Asp Ile Val Glu Thr Ser Pro Ile Pro Leu Thr Tyr 
                85                  90                  95      

Glu Asp Ile Asp Leu Pro Ser Asn Trp Gln Glu Val Thr Ser Ala Ala 
            100                 105                 110         

Asp Tyr Glu Lys Ala Ile Ala Gln Ile His His His Leu Arg Gln Gly 
        115                 120                 125             

Asp Thr Tyr Gln Val Asn Tyr Thr Val Gln Leu Lys Gln Lys Leu Asn 
    130                 135                 140                 

Ala Asn Pro Phe Ala Ile Tyr Asn Arg Met Val Val Glu Gln Glu Ala 
145                 150                 155                 160 

Gly Tyr Asn Ala Tyr Val Glu His Asp Glu Met Thr Val Ile Ser Met 
                165                 170                 175     

Ser Pro Glu Leu Phe Phe Glu Gln Asn Asp Arg Glu Leu Thr Thr Arg 
            180                 185                 190         

Pro Met Lys Gly Thr Thr Gln Arg Gly Val Thr Asp Gln Glu Asp Leu 
        195                 200                 205             

Glu Gln Ala Ser Trp Leu Glu Gln Asp Pro Lys Asn Arg Ser Glu Asn 
    210                 215                 220                 

Met Met Ile Val Asp Leu Leu Arg Asn Asp Met Asn Arg Ile Ser Glu 
225                 230                 235                 240 

Val Gly Ser Glu His Val Glu Arg Leu Cys Gln Val Glu Gln Tyr Ser 
                245                 250                 255     

Thr Val Trp Gln Met Thr Ser Thr Ile Lys Ser Gln Leu Arg Glu Asp 
            260                 265                 270         

Val Asp Leu Val Glu Ile Phe Arg Ser Leu Phe Pro Cys Gly Ser Ile 
        275                 280                 285             

Thr Gly Ala Pro Lys Ile Ala Thr Met Glu Ile Ile Lys Asp Leu Glu 
    290                 295                 300                 

Pro Gln Pro Arg Gly Val Tyr Cys Gly Thr Ile Gly Leu Leu Leu Pro 
305                 310                 315                 320 

Asn Gly Arg Arg Ile Phe Asn Val Ala Ile Arg Thr Ile Gln Leu His 
                325                 330                 335     

Lys Gly Gln Ala Ile Tyr Gly Val Gly Gly Gly Ile Thr Trp Asp Ser 
            340                 345                 350         

Thr Trp Glu Ser Glu Tyr Arg Glu Val His Gln Lys Ala Ala Val Leu 
        355                 360                 365             

Tyr Arg Lys Gln Ala Arg Phe Gln Leu Ile Thr Thr Gly Lys Ile Ser 
    370                 375                 380                 

Gln Lys Gln Leu Met Phe Glu Glu Gln His Leu Glu Arg Leu Arg Lys 
385                 390                 395                 400 

Ala Ser Arg Tyr Phe Ala Phe Pro Phe Asp Ala Glu Asp Leu Gly His 
                405                 410                 415     

Lys Ile Glu Glu Glu Cys Gln Asp Cys Glu Ala Asn Arg Asp Tyr Arg 
            420                 425                 430         

Leu Arg Ile Ser Leu Ser Lys Ser Gly Glu Ile Glu Val Asn Arg Gln 
        435                 440                 445             

Val Leu Thr Pro Leu Ser Thr Ser Phe Cys Gln Ala Gln Val Cys Leu 
    450                 455                 460                 

Gln Glu Ala Ala Leu Asn Gln Ser Phe Thr Tyr Phe Lys Thr Thr His 
465                 470                 475                 480 

Arg Pro His Leu Ser Leu Gly Glu Gln Glu Lys Ile Tyr His Asn Lys 
                485                 490                 495     

Ser Gly Glu Leu Leu Glu Thr Ser Ile Gly Asn Leu Val Leu Lys Ile 
            500                 505                 510         

Ala Gly Lys Leu Tyr Thr Pro Pro Ile Arg Leu Gly Ile Leu Pro Gly 
        515                 520                 525             

Ile Tyr Arg Gln His Leu Leu Glu Thr Gly Gln Val Glu Glu Lys Val 
    530                 535                 540                 

Leu Thr Leu Ala Asp Leu Thr Gln Ala Glu Ala Ile Tyr Gly Cys Asn 
545                 550                 555                 560 

Ala Val Arg Gly Leu Tyr Glu Leu Ser Leu Glu Glu Asn 
                565                 570             

<210>   1239
<211>   615
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1239
atgaaattaa tatttttgca tgggttaggg cagtcagcag agtcttggaa agaagttcgg   60
aatctactga cagattatcc ttctgaggct atcgagttat ttccttctgg agttagtaac   120
tatcaacaag ctaaagagcg agtttatcag cacctagctc aagagacaga accttttgtt   180
ttgattggat tgtccttagg tgctgccctg acactagaac tttccagtta cgatttacca   240
aatcttcgag ctttgattct gtcaggatgc ccgcttaaat tagcagggaa tatcctattt   300
tatcttcaat tgctgatttt taaactactt cccaaaagag tatttgaaaa acagggagca   360
gacaagactc ttatggtcgg agtttctgag gagttgaaga cacttgattt aacggatata   420
gcaggaactt acccttatcc aaccttacta atttgtggca gcaaagataa accgaatctt   480
agttctatga aagctctcca tagactgtta acagattcgc agtttcagat cattcctgat   540
ggccctcatg tcttgaataa ggcaaaacca aaggagtttg tagaaaagac cagaagtttc   600
cttgaattgc tgaaa                                                    615

<210>   1240
<211>   205
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane

<400>   1240
Met Lys Leu Ile Phe Leu His Gly Leu Gly Gln Ser Ala Glu Ser Trp 
1               5                   10                  15      

Lys Glu Val Arg Asn Leu Leu Thr Asp Tyr Pro Ser Glu Ala Ile Glu 
            20                  25                  30          

Leu Phe Pro Ser Gly Val Ser Asn Tyr Gln Gln Ala Lys Glu Arg Val 
        35                  40                  45              

Tyr Gln His Leu Ala Gln Glu Thr Glu Pro Phe Val Leu Ile Gly Leu 
    50                  55                  60                  

Ser Leu Gly Ala Ala Leu Thr Leu Glu Leu Ser Ser Tyr Asp Leu Pro 
65                  70                  75                  80  

Asn Leu Arg Ala Leu Ile Leu Ser Gly Cys Pro Leu Lys Leu Ala Gly 
                85                  90                  95      

Asn Ile Leu Phe Tyr Leu Gln Leu Leu Ile Phe Lys Leu Leu Pro Lys 
            100                 105                 110         

Arg Val Phe Glu Lys Gln Gly Ala Asp Lys Thr Leu Met Val Gly Val 
        115                 120                 125             

Ser Glu Glu Leu Lys Thr Leu Asp Leu Thr Asp Ile Ala Gly Thr Tyr 
    130                 135                 140                 

Pro Tyr Pro Thr Leu Leu Ile Cys Gly Ser Lys Asp Lys Pro Asn Leu 
145                 150                 155                 160 

Ser Ser Met Lys Ala Leu His Arg Leu Leu Thr Asp Ser Gln Phe Gln 
                165                 170                 175     

Ile Ile Pro Asp Gly Pro His Val Leu Asn Lys Ala Lys Pro Lys Glu 
            180                 185                 190         

Phe Val Glu Lys Thr Arg Ser Phe Leu Glu Leu Leu Lys 
        195                 200                 205 

<210>   1241
<211>   996
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1241
atgaataaac gtctattttc aaaaatgagt ctggtgacgt tgccaatttt agccttgttt   60
tcacaatcag ttttggcgga agaaaacatc catttttcga gctgtaagga agcttgggcg   120
aatggctatt cggatattca cgagggagaa cctggttatt ctgccaagtt agaccgtgat   180
catgatggtg tggcttgcga attgaaaaat gctcctaagg gtgcttttaa agcaaaacag   240
tcaacggcta ttcaaatcaa cacaagttca gcaacaacaa gtggttgggt taagcaggac   300
ggcgcttggt actactttga tggaaatgga aatctagtga aaaatgcatg gcagggaagc   360
tattacctga aagctgatgg taaaatggca cagagtgaat ggatttatga ctcttcttat   420
caagcttggt attatttgaa atcagatggt tcttatgcaa aaaatgcatg gcaaggagct   480
tattacctta aatcaaacgg taaaatggca caaggtgagt gggtttatga ttcttcttac   540
caagcatggt attacttgaa atcagatggt tcatatgctc gcaatgcatg gcaaggaaac   600
tactatttga aatcagatgg taaaatggct aaaggtgaat gggtttatga tgccacctat   660
caagcttggt attatttgac atcagatggt tcttatgctt acagtacatg gcaaggaaat   720
tactatctaa aatcggatgg taaaatggct gtcaatgaat gggttgatgg tggacgttat   780
tatgttggcg ctgacggagt ttggaaggaa gttcaagcaa gtacagcttc ttctagtaat   840
gatagcaata gtgaatattc tgctgcttta ggaaaggcaa aaagttataa ttcgttattc   900
cacatgtcaa aaaaacgtat gtatagacaa ttaacttctg attttgataa attttcaaat   960
gatgcagctc aatatgccat tgatcattta gatgat                             996

<210>   1242
<211>   332
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pneumococcal surface protein, putative
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15902627 (0.E+01)

<400>   1242
Met Asn Lys Arg Leu Phe Ser Lys Met Ser Leu Val Thr Leu Pro Ile 
1               5                   10                  15      

Leu Ala Leu Phe Ser Gln Ser Val Leu Ala Glu Glu Asn Ile His Phe 
            20                  25                  30          

Ser Ser Cys Lys Glu Ala Trp Ala Asn Gly Tyr Ser Asp Ile His Glu 
        35                  40                  45              

Gly Glu Pro Gly Tyr Ser Ala Lys Leu Asp Arg Asp His Asp Gly Val 
    50                  55                  60                  

Ala Cys Glu Leu Lys Asn Ala Pro Lys Gly Ala Phe Lys Ala Lys Gln 
65                  70                  75                  80  

Ser Thr Ala Ile Gln Ile Asn Thr Ser Ser Ala Thr Thr Ser Gly Trp 
                85                  90                  95      

Val Lys Gln Asp Gly Ala Trp Tyr Tyr Phe Asp Gly Asn Gly Asn Leu 
            100                 105                 110         

Val Lys Asn Ala Trp Gln Gly Ser Tyr Tyr Leu Lys Ala Asp Gly Lys 
        115                 120                 125             

Met Ala Gln Ser Glu Trp Ile Tyr Asp Ser Ser Tyr Gln Ala Trp Tyr 
    130                 135                 140                 

Tyr Leu Lys Ser Asp Gly Ser Tyr Ala Lys Asn Ala Trp Gln Gly Ala 
145                 150                 155                 160 

Tyr Tyr Leu Lys Ser Asn Gly Lys Met Ala Gln Gly Glu Trp Val Tyr 
                165                 170                 175     

Asp Ser Ser Tyr Gln Ala Trp Tyr Tyr Leu Lys Ser Asp Gly Ser Tyr 
            180                 185                 190         

Ala Arg Asn Ala Trp Gln Gly Asn Tyr Tyr Leu Lys Ser Asp Gly Lys 
        195                 200                 205             

Met Ala Lys Gly Glu Trp Val Tyr Asp Ala Thr Tyr Gln Ala Trp Tyr 
    210                 215                 220                 

Tyr Leu Thr Ser Asp Gly Ser Tyr Ala Tyr Ser Thr Trp Gln Gly Asn 
225                 230                 235                 240 

Tyr Tyr Leu Lys Ser Asp Gly Lys Met Ala Val Asn Glu Trp Val Asp 
                245                 250                 255     

Gly Gly Arg Tyr Tyr Val Gly Ala Asp Gly Val Trp Lys Glu Val Gln 
            260                 265                 270         

Ala Ser Thr Ala Ser Ser Ser Asn Asp Ser Asn Ser Glu Tyr Ser Ala 
        275                 280                 285             

Ala Leu Gly Lys Ala Lys Ser Tyr Asn Ser Leu Phe His Met Ser Lys 
    290                 295                 300                 

Lys Arg Met Tyr Arg Gln Leu Thr Ser Asp Phe Asp Lys Phe Ser Asn 
305                 310                 315                 320 

Asp Ala Ala Gln Tyr Ala Ile Asp His Leu Asp Asp 
                325                 330         

<210>   1243
<211>   960
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1243
atgatgagtc aaaagattat tgggattgac cttggtggaa cttctatcaa atttgcaatc   60
ttaacaacag caggagaaat ccaaggaaaa tggtcaatca agaccaacat tttggatgag   120
ggaagtcata tcgttgatga tatgattgag tctattcaac atcgtttgga cttgcttgga   180
ttggcagcag cggacttcca aggcattgga atgggatcac caggtgtggt tgaccgtgac   240
aaagggactg ttatcggtgc ctacaacttg aactggaaaa cccttcaacc aatcaaacaa   300
aagattgaaa aagctttggg cattccattt ttcatcgata atgatgccaa cgtagcagct   360
cttggtgagc gctggatggg tgctggagat aaccaaccag acgttgtctt tataacactc   420
ggtactggtg ttggtggtgg tattgtcgca gaaggcaaat tgcttcatgg tgttgctggt   480
gcagcaggtg aacttggtca tatcactgtt gactttgacc aaccaatctc atgtacttgt   540
ggtaaaaaag gctgccttga gacagttgct tcagcaacag ggattgtcaa cttgactcgt   600
cgctatgccg atgaatacga aggcgatgca gccttgaaac gcttgattga taacggagaa   660
gaagtaactg ctaagactgt ctttgatctc gcaaaagaag gagacgacct tgctttgatt   720
gtttaccgta acttctcacg ttacttggga atcgcttgtg ctaacattgg ttcaatccta   780
aacccatcaa caatcgtcat cggtggtggt gtgtcagctg cgggagaatt ccttctacaa   840
ggtgttcaaa aagtttacga tgaaaatagt ttcccacaag tacgcacatc tactaaatta   900
gctcttgcaa ctctaggaaa tgacgctgga gttatcggag cagcatcact tgtattgcaa   960

<210>   1244
<211>   320
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucokinase (gki)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902628 (0.E+01)

<400>   1244
Met Met Ser Gln Lys Ile Ile Gly Ile Asp Leu Gly Gly Thr Ser Ile 
1               5                   10                  15      

Lys Phe Ala Ile Leu Thr Thr Ala Gly Glu Ile Gln Gly Lys Trp Ser 
            20                  25                  30          

Ile Lys Thr Asn Ile Leu Asp Glu Gly Ser His Ile Val Asp Asp Met 
        35                  40                  45              

Ile Glu Ser Ile Gln His Arg Leu Asp Leu Leu Gly Leu Ala Ala Ala 
    50                  55                  60                  

Asp Phe Gln Gly Ile Gly Met Gly Ser Pro Gly Val Val Asp Arg Asp 
65                  70                  75                  80  

Lys Gly Thr Val Ile Gly Ala Tyr Asn Leu Asn Trp Lys Thr Leu Gln 
                85                  90                  95      

Pro Ile Lys Gln Lys Ile Glu Lys Ala Leu Gly Ile Pro Phe Phe Ile 
            100                 105                 110         

Asp Asn Asp Ala Asn Val Ala Ala Leu Gly Glu Arg Trp Met Gly Ala 
        115                 120                 125             

Gly Asp Asn Gln Pro Asp Val Val Phe Ile Thr Leu Gly Thr Gly Val 
    130                 135                 140                 

Gly Gly Gly Ile Val Ala Glu Gly Lys Leu Leu His Gly Val Ala Gly 
145                 150                 155                 160 

Ala Ala Gly Glu Leu Gly His Ile Thr Val Asp Phe Asp Gln Pro Ile 
                165                 170                 175     

Ser Cys Thr Cys Gly Lys Lys Gly Cys Leu Glu Thr Val Ala Ser Ala 
            180                 185                 190         

Thr Gly Ile Val Asn Leu Thr Arg Arg Tyr Ala Asp Glu Tyr Glu Gly 
        195                 200                 205             

Asp Ala Ala Leu Lys Arg Leu Ile Asp Asn Gly Glu Glu Val Thr Ala 
    210                 215                 220                 

Lys Thr Val Phe Asp Leu Ala Lys Glu Gly Asp Asp Leu Ala Leu Ile 
225                 230                 235                 240 

Val Tyr Arg Asn Phe Ser Arg Tyr Leu Gly Ile Ala Cys Ala Asn Ile 
                245                 250                 255     

Gly Ser Ile Leu Asn Pro Ser Thr Ile Val Ile Gly Gly Gly Val Ser 
            260                 265                 270         

Ala Ala Gly Glu Phe Leu Leu Gln Gly Val Gln Lys Val Tyr Asp Glu 
        275                 280                 285             

Asn Ser Phe Pro Gln Val Arg Thr Ser Thr Lys Leu Ala Leu Ala Thr 
    290                 295                 300                 

Leu Gly Asn Asp Ala Gly Val Ile Gly Ala Ala Ser Leu Val Leu Gln 
305                 310                 315                 320 


<210>   1245
<211>   837
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1245
atgacaaaag cagatacgat ttttaaagag aatattgaac gcattctaaa ggaaggtgtt   60
ttctcagagc aggctcgtcc taagtacaag gatgggactg ttgctaattc caagtatgta   120
actggtgcct tttccgagta cgacttatct aaaggagaat ttcctatcac aaccttgcgt   180
cccattgcaa tcaaatccgc catcaaagaa gttctctgga tttaccaaga ccagtcaaat   240
agcttagaag tgcttaatga caagtacaat gttcactact ggaatgactg ggaagttgga   300
gacacgggaa ccattggtga gcgctatggt gccgttgtta agaaacacga cattatcaat   360
aagcttctca aacagttgga aaccaatcct tggaaccgcc gcaatattat ttcgctctgg   420
gattaccaag ctttcgaaga aacagatggg ctgctcccgt gcgcctttca gaccatgttt   480
gatgttcggc gtgttgatgg ggaaatctat ctggatgcga ccttgaccca gcgctccaat   540
gatatgctgg tggcccacca catcaacgct atgcagtatg tggctttgca gatgatgatt   600
gccaaacatt ttggctggaa ggttgggaag ttcttctact tcatcaacaa cctccatatc   660
tatgataatc aatttgaaca agctcaggaa ttgctccgtc gggagccgtc aaactgccaa   720
ccacgcttgg ttttaaatgt tcctgatggg actaatttct ttgatatcaa agcagaagat   780
tttgagttgg tggattatga ccctgttaag ccacagttga agtttgacct agctatt      837

<210>   1246
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thymidylate synthase (thyA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902629 (e-166)

<400>   1246
Met Thr Lys Ala Asp Thr Ile Phe Lys Glu Asn Ile Glu Arg Ile Leu 
1               5                   10                  15      

Lys Glu Gly Val Phe Ser Glu Gln Ala Arg Pro Lys Tyr Lys Asp Gly 
            20                  25                  30          

Thr Val Ala Asn Ser Lys Tyr Val Thr Gly Ala Phe Ser Glu Tyr Asp 
        35                  40                  45              

Leu Ser Lys Gly Glu Phe Pro Ile Thr Thr Leu Arg Pro Ile Ala Ile 
    50                  55                  60                  

Lys Ser Ala Ile Lys Glu Val Leu Trp Ile Tyr Gln Asp Gln Ser Asn 
65                  70                  75                  80  

Ser Leu Glu Val Leu Asn Asp Lys Tyr Asn Val His Tyr Trp Asn Asp 
                85                  90                  95      

Trp Glu Val Gly Asp Thr Gly Thr Ile Gly Glu Arg Tyr Gly Ala Val 
            100                 105                 110         

Val Lys Lys His Asp Ile Ile Asn Lys Leu Leu Lys Gln Leu Glu Thr 
        115                 120                 125             

Asn Pro Trp Asn Arg Arg Asn Ile Ile Ser Leu Trp Asp Tyr Gln Ala 
    130                 135                 140                 

Phe Glu Glu Thr Asp Gly Leu Leu Pro Cys Ala Phe Gln Thr Met Phe 
145                 150                 155                 160 

Asp Val Arg Arg Val Asp Gly Glu Ile Tyr Leu Asp Ala Thr Leu Thr 
                165                 170                 175     

Gln Arg Ser Asn Asp Met Leu Val Ala His His Ile Asn Ala Met Gln 
            180                 185                 190         

Tyr Val Ala Leu Gln Met Met Ile Ala Lys His Phe Gly Trp Lys Val 
        195                 200                 205             

Gly Lys Phe Phe Tyr Phe Ile Asn Asn Leu His Ile Tyr Asp Asn Gln 
    210                 215                 220                 

Phe Glu Gln Ala Gln Glu Leu Leu Arg Arg Glu Pro Ser Asn Cys Gln 
225                 230                 235                 240 

Pro Arg Leu Val Leu Asn Val Pro Asp Gly Thr Asn Phe Phe Asp Ile 
                245                 250                 255     

Lys Ala Glu Asp Phe Glu Leu Val Asp Tyr Asp Pro Val Lys Pro Gln 
            260                 265                 270         

Leu Lys Phe Asp Leu Ala Ile 
        275                 

<210>   1247
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1247
atggctaaag gattcgctaa aggtcttgta acaggtgtcg caggaactgt cgctgccgtt   60
gcaggtgcag tatacgcatt taaaaagaaa gtaatcgaac cagaagagca aaaagcagct   120
ttcatcgaag aaaaccgtaa aaaagcagct cgtcgccgcg tatcacgt                168

<210>   1248
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902630 (3.E-26)

<400>   1248
Met Ala Lys Gly Phe Ala Lys Gly Leu Val Thr Gly Val Ala Gly Thr 
1               5                   10                  15      

Val Ala Ala Val Ala Gly Ala Val Tyr Ala Phe Lys Lys Lys Val Ile 
            20                  25                  30          

Glu Pro Glu Glu Gln Lys Ala Ala Phe Ile Glu Glu Asn Arg Lys Lys 
        35                  40                  45              

Ala Ala Arg Arg Arg Val Ser Arg 
    50                  55      

<210>   1249
<211>   186
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1249
atgaaagctg ctttttgctc ttctggttcg attactttct ttttaaatgc gtatactgca   60
cctgcaacgg cagcgacagt tcctgcgaca cctgttacaa gacctttagc gaatccttta   120
gccatgagtc ttcctccttt atattctcaa tcagccagcc tcctcaagag gtcacatttt   180
tctgac                                                              186

<210>   1250
<211>   62
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1250
Met Lys Ala Ala Phe Cys Ser Ser Gly Ser Ile Thr Phe Phe Leu Asn 
1               5                   10                  15      

Ala Tyr Thr Ala Pro Ala Thr Ala Ala Thr Val Pro Ala Thr Pro Val 
            20                  25                  30          

Thr Arg Pro Leu Ala Asn Pro Leu Ala Met Ser Leu Pro Pro Leu Tyr 
        35                  40                  45              

Ser Gln Ser Ala Ser Leu Leu Lys Arg Ser His Phe Ser Asp 
    50                  55                  60          

<210>   1251
<211>   882
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1251
atgaaaacaa aaataattgt gattgttgga ccgactgctg ttggaaagac ggctctagct   60
attgaagttg caaagcgttt taatggcgaa gtggttagtg gagatagcca gcaagtctat   120
cgaggacttg atattgggac ggccaaggct agtccagaag agcaggcagc tgttcctcat   180
catttaatcg atgttagaga gataaccgag tcttactcgg cttttgattt tgtttcagaa   240
gctaagatga ctattgaggg tattcacaac cgtggcaagc tagccattat cgccggtggg   300
actggacttt atatccagag cttgctagaa ggttaccacc taggtgggga gactcctcat   360
gaggagattt tagcttatcg agctagtttg gagccatatt cagatgagga attagcccat   420
ttggtggatc aagcaggcct tgagattccc cagtttaatc gtcgtcgtgc tatgcgtgcc   480
ttagaaattg cccattttgg tcaggatttg gaaaatcaag agaccttgta tgaaccgctg   540
attatctgct tggatgatga acgtagtcaa ctttatgagc gtatcaacca ccgagtggat   600
ttgatgtttg aggctgggct tttggatgag gccaagtggc tgtttgacca ttcccctaat   660
gtacaggctg ctaaaggaat tggctataag gaactctttc cttatttccg tggagagcag   720
accttggagg aagctagtga gagtcttaaa caggcgactc gtcgttttgc caagcgtcag   780
ctgacctggt tccgtaatcg catgcaggtc accttttatc agattggaga atctggtgta   840
caagaccgca ttttaagcca gatagaggag tttttagatg at                      882

<210>   1252
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tRNA isopentenylpyrophosphate transferase (miaA)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902632 (e-164)

<400>   1252
Met Lys Thr Lys Ile Ile Val Ile Val Gly Pro Thr Ala Val Gly Lys 
1               5                   10                  15      

Thr Ala Leu Ala Ile Glu Val Ala Lys Arg Phe Asn Gly Glu Val Val 
            20                  25                  30          

Ser Gly Asp Ser Gln Gln Val Tyr Arg Gly Leu Asp Ile Gly Thr Ala 
        35                  40                  45              

Lys Ala Ser Pro Glu Glu Gln Ala Ala Val Pro His His Leu Ile Asp 
    50                  55                  60                  

Val Arg Glu Ile Thr Glu Ser Tyr Ser Ala Phe Asp Phe Val Ser Glu 
65                  70                  75                  80  

Ala Lys Met Thr Ile Glu Gly Ile His Asn Arg Gly Lys Leu Ala Ile 
                85                  90                  95      

Ile Ala Gly Gly Thr Gly Leu Tyr Ile Gln Ser Leu Leu Glu Gly Tyr 
            100                 105                 110         

His Leu Gly Gly Glu Thr Pro His Glu Glu Ile Leu Ala Tyr Arg Ala 
        115                 120                 125             

Ser Leu Glu Pro Tyr Ser Asp Glu Glu Leu Ala His Leu Val Asp Gln 
    130                 135                 140                 

Ala Gly Leu Glu Ile Pro Gln Phe Asn Arg Arg Arg Ala Met Arg Ala 
145                 150                 155                 160 

Leu Glu Ile Ala His Phe Gly Gln Asp Leu Glu Asn Gln Glu Thr Leu 
                165                 170                 175     

Tyr Glu Pro Leu Ile Ile Cys Leu Asp Asp Glu Arg Ser Gln Leu Tyr 
            180                 185                 190         

Glu Arg Ile Asn His Arg Val Asp Leu Met Phe Glu Ala Gly Leu Leu 
        195                 200                 205             

Asp Glu Ala Lys Trp Leu Phe Asp His Ser Pro Asn Val Gln Ala Ala 
    210                 215                 220                 

Lys Gly Ile Gly Tyr Lys Glu Leu Phe Pro Tyr Phe Arg Gly Glu Gln 
225                 230                 235                 240 

Thr Leu Glu Glu Ala Ser Glu Ser Leu Lys Gln Ala Thr Arg Arg Phe 
                245                 250                 255     

Ala Lys Arg Gln Leu Thr Trp Phe Arg Asn Arg Met Gln Val Thr Phe 
            260                 265                 270         

Tyr Gln Ile Gly Glu Ser Gly Val Gln Asp Arg Ile Leu Ser Gln Ile 
        275                 280                 285             

Glu Glu Phe Leu Asp Asp 
    290                 

<210>   1253
<211>   1236
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1253
atgattgaaa cggagaaaaa agaggagcga gtcctgctga ttggtgtgga attgcagggt   60
atggacagtt ttgacctctc catggaagaa ttggctagtt tagcgaaaac ggcaggggca   120
gtcgttgtag atagctacag acaaaaacgt gaaaaatatg attccaagac cttcgtcggc   180

tctggtaagt tggaagagat tgcgcttatg gtggatgcag aagaaatcac tactgtcatc   240
gtcaacaatc gtctgacccc aaggcagaat gtcaatctag aggaagttct cggtgttaag   300
gtcattgacc gtatgcagtt gattttggat atctttgcca tgcgggctcg aagccatgaa   360
gggaagctcc aagtccacct agcccaactc aaataccttt tgcctcgctt ggttggtcag   420
gggattatgc tcagccgtca ggcaggggga attggttccc gtggtcctgg tgaaagccag   480
ctggagctga accgtcgtag cgttcgcaat caaatcacgg atatcgagcg ccagctcaag   540
gtggttgaga aaaatcgtgc gactgtcaga gaaaaacgtt tggagtctag cacttttaag   600
attggtttga ttggttatac taatgctggg aaatcaacta tcatgaacat cttgaccagt   660
aagacccagt atgaagcaga tgagctcttt gcgactctgg atgcgacaac caagagtatt   720
catctgggag gcaatctcca agtaactttg acagataccg ttggctttat ccaagatttg   780
ccgacagagt tggtgtccag tttcaagtca accttggaag aaagcaagca tgtggacctt   840
ctggttcatg ttatcgatgc tagcaatcct taccacgagg agcatgaaaa aacggttctc   900
tccatcatga aagacctgga catggaagat attcctcact tgacgcttta taataaagcg   960
gatttggtgg aggatttcac gcctacccaa acgccatata ccctcatttc tgccaagtct   1020
gaggacagtc gtgaaaactt gcaagcatta ttgctagata agattaagga aatttttgaa   1080
gcatttaccc tgcgagtgcc tttttcaaag tcctacaaga ttcatgattt agagagtgtt   1140
gcaattctgg aagaacgtga ttatcaggaa gacggcgaag tgattacagg ctacatttcc   1200
gagaaaaata aatggaggtt agaagaattt tatgac                             1236

<210>   1254
<211>   412
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP-binding protein HflX (hflX)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902633 (0.E+01)

<400>   1254
Met Ile Glu Thr Glu Lys Lys Glu Glu Arg Val Leu Leu Ile Gly Val 
1               5                   10                  15      

Glu Leu Gln Gly Met Asp Ser Phe Asp Leu Ser Met Glu Glu Leu Ala 
            20                  25                  30          

Ser Leu Ala Lys Thr Ala Gly Ala Val Val Val Asp Ser Tyr Arg Gln 
        35                  40                  45              

Lys Arg Glu Lys Tyr Asp Ser Lys Thr Phe Val Gly Ser Gly Lys Leu 
    50                  55                  60                  

Glu Glu Ile Ala Leu Met Val Asp Ala Glu Glu Ile Thr Thr Val Ile 
65                  70                  75                  80  

Val Asn Asn Arg Leu Thr Pro Arg Gln Asn Val Asn Leu Glu Glu Val 
                85                  90                  95      

Leu Gly Val Lys Val Ile Asp Arg Met Gln Leu Ile Leu Asp Ile Phe 
            100                 105                 110         

Ala Met Arg Ala Arg Ser His Glu Gly Lys Leu Gln Val His Leu Ala 
        115                 120                 125             

Gln Leu Lys Tyr Leu Leu Pro Arg Leu Val Gly Gln Gly Ile Met Leu 
    130                 135                 140                 

Ser Arg Gln Ala Gly Gly Ile Gly Ser Arg Gly Pro Gly Glu Ser Gln 
145                 150                 155                 160 

Leu Glu Leu Asn Arg Arg Ser Val Arg Asn Gln Ile Thr Asp Ile Glu 
                165                 170                 175     

Arg Gln Leu Lys Val Val Glu Lys Asn Arg Ala Thr Val Arg Glu Lys 
            180                 185                 190         

Arg Leu Glu Ser Ser Thr Phe Lys Ile Gly Leu Ile Gly Tyr Thr Asn 
        195                 200                 205             

Ala Gly Lys Ser Thr Ile Met Asn Ile Leu Thr Ser Lys Thr Gln Tyr 
    210                 215                 220                 

Glu Ala Asp Glu Leu Phe Ala Thr Leu Asp Ala Thr Thr Lys Ser Ile 
225                 230                 235                 240 

His Leu Gly Gly Asn Leu Gln Val Thr Leu Thr Asp Thr Val Gly Phe 
                245                 250                 255     

Ile Gln Asp Leu Pro Thr Glu Leu Val Ser Ser Phe Lys Ser Thr Leu 
            260                 265                 270         

Glu Glu Ser Lys His Val Asp Leu Leu Val His Val Ile Asp Ala Ser 
        275                 280                 285             

Asn Pro Tyr His Glu Glu His Glu Lys Thr Val Leu Ser Ile Met Lys 
    290                 295                 300                 

Asp Leu Asp Met Glu Asp Ile Pro His Leu Thr Leu Tyr Asn Lys Ala 
305                 310                 315                 320 

Asp Leu Val Glu Asp Phe Thr Pro Thr Gln Thr Pro Tyr Thr Leu Ile 
                325                 330                 335     

Ser Ala Lys Ser Glu Asp Ser Arg Glu Asn Leu Gln Ala Leu Leu Leu 
            340                 345                 350         

Asp Lys Ile Lys Glu Ile Phe Glu Ala Phe Thr Leu Arg Val Pro Phe 
        355                 360                 365             

Ser Lys Ser Tyr Lys Ile His Asp Leu Glu Ser Val Ala Ile Leu Glu 
    370                 375                 380                 

Glu Arg Asp Tyr Gln Glu Asp Gly Glu Val Ile Thr Gly Tyr Ile Ser 
385                 390                 395                 400 

Glu Lys Asn Lys Trp Arg Leu Glu Glu Phe Tyr Asp 
                405                 410         

<210>   1255
<211>   621
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1255
atgactgata ttaaaacttt ggctctaaag tatggaggtt atacaagtct ggacaaggtc   60
tatctggatc agcttctagc tggtaaaaca gatcaggagc agttaacact tattacacct   120
ccgccaagtg ttgttaatgc ctactttgca gaactctatc agaaaaagag tcctcaggct   180
gcgacggatt attttgcaga actcagtcag gaactgaatc tttacaatac tgagccaagt   240
ttcaccctag aaaataagcc ttttattcgg cttaatctgt ctggtaaatc ctttggtttt   300
tgttatgaga gtgacggcct tggtcggatt ttctttgaaa atgaggagaa aatctcggat   360
gacttgctct ttgaaattgc gcaaattttc ccccatcaat tagtctttga agagtctggt   420
aagatttaca tgaagcctgt cgaggacgag gaagttatca gcctagaaag tctcacagct   480
ttgactgatt tggaaagatt ggctgatggt cgaaaacgtc tcaaaggcta cagccaagag   540
gatttattgc aagaagctgc tgctttttct ggcaaacgct atttccgatc ggaaaaccgc   600
acagccatgt tatatattga t                                             621

<210>   1256
<211>   207
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902634 (e-115)

<400>   1256
Met Thr Asp Ile Lys Thr Leu Ala Leu Lys Tyr Gly Gly Tyr Thr Ser 
1               5                   10                  15      

Leu Asp Lys Val Tyr Leu Asp Gln Leu Leu Ala Gly Lys Thr Asp Gln 
            20                  25                  30          

Glu Gln Leu Thr Leu Ile Thr Pro Pro Pro Ser Val Val Asn Ala Tyr 
        35                  40                  45              

Phe Ala Glu Leu Tyr Gln Lys Lys Ser Pro Gln Ala Ala Thr Asp Tyr 
    50                  55                  60                  

Phe Ala Glu Leu Ser Gln Glu Leu Asn Leu Tyr Asn Thr Glu Pro Ser 
65                  70                  75                  80  

Phe Thr Leu Glu Asn Lys Pro Phe Ile Arg Leu Asn Leu Ser Gly Lys 
                85                  90                  95      

Ser Phe Gly Phe Cys Tyr Glu Ser Asp Gly Leu Gly Arg Ile Phe Phe 
            100                 105                 110         

Glu Asn Glu Glu Lys Ile Ser Asp Asp Leu Leu Phe Glu Ile Ala Gln 
        115                 120                 125             

Ile Phe Pro His Gln Leu Val Phe Glu Glu Ser Gly Lys Ile Tyr Met 
    130                 135                 140                 

Lys Pro Val Glu Asp Glu Glu Val Ile Ser Leu Glu Ser Leu Thr Ala 
145                 150                 155                 160 

Leu Thr Asp Leu Glu Arg Leu Ala Asp Gly Arg Lys Arg Leu Lys Gly 
                165                 170                 175     

Tyr Ser Gln Glu Asp Leu Leu Gln Glu Ala Ala Ala Phe Ser Gly Lys 
            180                 185                 190         

Arg Tyr Phe Arg Ser Glu Asn Arg Thr Ala Met Leu Tyr Ile Asp 
        195                 200                 205         

<210>   1257
<211>   927
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1257
atggatattc aatttttagg aacgggggct ggtcagccct ctaaagcccg caacgtttca   60
agtctcgccc tgaaactttt ggatgagatt aacgaagttt ggctctttga ctgtggagaa   120
ggtacgcaaa atcgcattct ggaaaccaca attcgaccac gtaaggtcag caaaatcttt   180
attacccatc tgcatggaga ccacattttt ggtttgccag gtttcctttc tagccgtgcc   240
tttcaggcca atgaagagca gacagatttg gaaatctacg gacctcaagg aatcaagtca   300
tttgtcttaa ccagccttcg tgtgtcaggt tctcgtctgc cctaccgcat tcatttccat   360
gagtttgacc aagattctct gggtaaaatt cttgaaaccg ataaattcac tgtgtatgca   420
gaggagctgg accacactat tttctgtgtt ggctatcgtg tcatgcaaaa ggatctagaa   480
gggacgctgg atgctgaaaa actcaaggct gctggtgttc cgttcggccc gctttttggt   540
aaaatcaaaa acggccagga tcttgttttg gaagacggaa ctgaaatcaa ggcagcagac   600
tatatctcag cgccacgtcc aggtaagatt atcactattt taggagacac tcgaaaaacg   660
ggtgccagtg tgcgtctggc tgtcaatgca gatgtcctag ttcatgagtc cacttatggc   720
aagggtgatg aaaaaattgc tcgtaaccat ggtcactcaa ctaatatgca agctgcacaa   780
gtagcggtag aagcaggtgc caaacgcctc ctactcaacc atatcagtgc ccgtttcctc   840
tcaaaagata ttagcaaact caagaaagac gctgccacaa tttttgaaaa tgtccatgtg   900
gtcaaagact tggaagaagt ggaaatc                                       927

<210>   1258
<211>   309
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   metallo-beta-lactamase superfamily protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902635 (e-176)

<400>   1258
Met Asp Ile Gln Phe Leu Gly Thr Gly Ala Gly Gln Pro Ser Lys Ala 
1               5                   10                  15      

Arg Asn Val Ser Ser Leu Ala Leu Lys Leu Leu Asp Glu Ile Asn Glu 
            20                  25                  30          

Val Trp Leu Phe Asp Cys Gly Glu Gly Thr Gln Asn Arg Ile Leu Glu 
        35                  40                  45              

Thr Thr Ile Arg Pro Arg Lys Val Ser Lys Ile Phe Ile Thr His Leu 
    50                  55                  60                  

His Gly Asp His Ile Phe Gly Leu Pro Gly Phe Leu Ser Ser Arg Ala 
65                  70                  75                  80  

Phe Gln Ala Asn Glu Glu Gln Thr Asp Leu Glu Ile Tyr Gly Pro Gln 
                85                  90                  95      

Gly Ile Lys Ser Phe Val Leu Thr Ser Leu Arg Val Ser Gly Ser Arg 
            100                 105                 110         

Leu Pro Tyr Arg Ile His Phe His Glu Phe Asp Gln Asp Ser Leu Gly 
        115                 120                 125             

Lys Ile Leu Glu Thr Asp Lys Phe Thr Val Tyr Ala Glu Glu Leu Asp 
    130                 135                 140                 

His Thr Ile Phe Cys Val Gly Tyr Arg Val Met Gln Lys Asp Leu Glu 
145                 150                 155                 160 

Gly Thr Leu Asp Ala Glu Lys Leu Lys Ala Ala Gly Val Pro Phe Gly 
                165                 170                 175     

Pro Leu Phe Gly Lys Ile Lys Asn Gly Gln Asp Leu Val Leu Glu Asp 
            180                 185                 190         

Gly Thr Glu Ile Lys Ala Ala Asp Tyr Ile Ser Ala Pro Arg Pro Gly 
        195                 200                 205             

Lys Ile Ile Thr Ile Leu Gly Asp Thr Arg Lys Thr Gly Ala Ser Val 
    210                 215                 220                 

Arg Leu Ala Val Asn Ala Asp Val Leu Val His Glu Ser Thr Tyr Gly 
225                 230                 235                 240 

Lys Gly Asp Glu Lys Ile Ala Arg Asn His Gly His Ser Thr Asn Met 
                245                 250                 255     

Gln Ala Ala Gln Val Ala Val Glu Ala Gly Ala Lys Arg Leu Leu Leu 
            260                 265                 270         

Asn His Ile Ser Ala Arg Phe Leu Ser Lys Asp Ile Ser Lys Leu Lys 
        275                 280                 285             

Lys Asp Ala Ala Thr Ile Phe Glu Asn Val His Val Val Lys Asp Leu 
    290                 295                 300                 

Glu Glu Val Glu Ile 
305                 

<210>   1259
<211>   753
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1259
atgcctacta ttctcattac cggagctagc ggtggtctag ctcaagaaat ggtcaaactc   60
ctgcccaatg accaactcat cttgcttggt agaaataagg aaaaattagc ccaactctac   120
ggaaattatt cccatgcaga attgattgaa attgatatta ccgacgattc agccctagaa   180
gctctggtaa ctgatcttta tctccgctat ggcaagattg atgtcttgat taacaacgct   240
ggttacggga tttttgaggg atttgaccag attgctgata aagatattca ccagatgttt   300
gaggtcaata cctttgccct gatgaatctg tctcgtcacc ttgcggctcg tatgaaggaa   360
agcagcaaag ggcatatcat caacatcgtc agcatggcag gtctaatagc tactggcaag   420
tctagtcttt actcagcgac caagtttgcg gctattggtt tttcaaatgc tctgcgactc   480
gaacttatgc cctatggagt ctatgtgaca acagtcaatc caggaccaat ccgtacagga   540
tttttcgacc aagccgaccc agatggaact tatcttaaat cggttgatcg cttcctgcta   600
gaaccagatg cagtggctaa aaagattgtc aagattatag gaaaaaacaa acgagaactc   660
aatctcccga ttttgttgaa cctagcccat aagttttata ctctctttcc caagctagct   720
gataagttgg caggggaaac ttttaattat aag                                753

<210>   1260
<211>   251
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, short chain dehydrogenase/reductase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902636 (e-141)

<400>   1260
Met Pro Thr Ile Leu Ile Thr Gly Ala Ser Gly Gly Leu Ala Gln Glu 
1               5                   10                  15      

Met Val Lys Leu Leu Pro Asn Asp Gln Leu Ile Leu Leu Gly Arg Asn 
            20                  25                  30          

Lys Glu Lys Leu Ala Gln Leu Tyr Gly Asn Tyr Ser His Ala Glu Leu 
        35                  40                  45              

Ile Glu Ile Asp Ile Thr Asp Asp Ser Ala Leu Glu Ala Leu Val Thr 
    50                  55                  60                  

Asp Leu Tyr Leu Arg Tyr Gly Lys Ile Asp Val Leu Ile Asn Asn Ala 
65                  70                  75                  80  

Gly Tyr Gly Ile Phe Glu Gly Phe Asp Gln Ile Ala Asp Lys Asp Ile 
                85                  90                  95      

His Gln Met Phe Glu Val Asn Thr Phe Ala Leu Met Asn Leu Ser Arg 
            100                 105                 110         

His Leu Ala Ala Arg Met Lys Glu Ser Ser Lys Gly His Ile Ile Asn 
        115                 120                 125             

Ile Val Ser Met Ala Gly Leu Ile Ala Thr Gly Lys Ser Ser Leu Tyr 
    130                 135                 140                 

Ser Ala Thr Lys Phe Ala Ala Ile Gly Phe Ser Asn Ala Leu Arg Leu 
145                 150                 155                 160 

Glu Leu Met Pro Tyr Gly Val Tyr Val Thr Thr Val Asn Pro Gly Pro 
                165                 170                 175     

Ile Arg Thr Gly Phe Phe Asp Gln Ala Asp Pro Asp Gly Thr Tyr Leu 
            180                 185                 190         

Lys Ser Val Asp Arg Phe Leu Leu Glu Pro Asp Ala Val Ala Lys Lys 
        195                 200                 205             

Ile Val Lys Ile Ile Gly Lys Asn Lys Arg Glu Leu Asn Leu Pro Ile 
    210                 215                 220                 

Leu Leu Asn Leu Ala His Lys Phe Tyr Thr Leu Phe Pro Lys Leu Ala 
225                 230                 235                 240 

Asp Lys Leu Ala Gly Glu Thr Phe Asn Tyr Lys 
                245                 250     

<210>   1261
<211>   996
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1261
ttgtgttttt ttcaagaaga gactcacaca atgctcctta ttttcctatc ttctttagcg   60
attctaaggc aagtatggta caataaaaac atgagaattc aacaattaca ttatattatc   120
aaaatcgtcg aaactggctc catgaatgag gcagccaagc aactctttat cactcagcca   180
agtctctcca atgcagtgcg agatttggaa aatgaaatgg gcattgagat ctttatccgc   240
aatcccaagg gaatcacctt gacccgtgat ggcatggagt ttctctctta tgcccgtcag   300
gttgtcgagc agacccagct tctggaggaa cgctataaaa atcctgtcgc ccaccgcgaa   360
ctctttagcg tttcgtctca acactatgcc tttgtggtca atgcctttgt ctctttgctc   420
aagaaaagcg atatggagaa atacgaactc ttccttcgtg aaactcggac ttgggagatt   480
atcgacgacg tcaagaactt ccgcagtgag gtcggggtcc tcttcttaaa cagttacaac   540
cgtgatgttt taaccaagat gctggatgac aatcacctgc tagcccacca tctcttcaca   600
gcgcaaccgc atatctttgt cagcaagacc aaccctctgg caaagaaaga caaggtgaaa   660
ctgtctgatt tggagaattt cccttacctc agctatgacc aagggacgca caactccttc   720
tacttttcag aagagattct ttctcaagaa caccacaaga aatccattgt ggtcagtgac   780
cgtgccaccc tctttaatct cttgattggt ttggatggtt ataccattgc gacagggatt   840
ttgaacagca acctaaacgg agacaatatc gtttctatcc cactggatat tgatgacccg   900
atcgagctgg tctatatcca gcatgagaaa accagcctat ctaagatggg cgaacgcttt   960
atagactatc tcctagaaga agttcagttt gatagt                             996

<210>   1262
<211>   332
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902637 (0.E+01)

<400>   1262
Met Cys Phe Phe Gln Glu Glu Thr His Thr Met Leu Leu Ile Phe Leu 
1               5                   10                  15      

Ser Ser Leu Ala Ile Leu Arg Gln Val Trp Tyr Asn Lys Asn Met Arg 
            20                  25                  30          

Ile Gln Gln Leu His Tyr Ile Ile Lys Ile Val Glu Thr Gly Ser Met 
        35                  40                  45              

Asn Glu Ala Ala Lys Gln Leu Phe Ile Thr Gln Pro Ser Leu Ser Asn 
    50                  55                  60                  

Ala Val Arg Asp Leu Glu Asn Glu Met Gly Ile Glu Ile Phe Ile Arg 
65                  70                  75                  80  

Asn Pro Lys Gly Ile Thr Leu Thr Arg Asp Gly Met Glu Phe Leu Ser 
                85                  90                  95      

Tyr Ala Arg Gln Val Val Glu Gln Thr Gln Leu Leu Glu Glu Arg Tyr 
            100                 105                 110         

Lys Asn Pro Val Ala His Arg Glu Leu Phe Ser Val Ser Ser Gln His 
        115                 120                 125             

Tyr Ala Phe Val Val Asn Ala Phe Val Ser Leu Leu Lys Lys Ser Asp 
    130                 135                 140                 

Met Glu Lys Tyr Glu Leu Phe Leu Arg Glu Thr Arg Thr Trp Glu Ile 
145                 150                 155                 160 

Ile Asp Asp Val Lys Asn Phe Arg Ser Glu Val Gly Val Leu Phe Leu 
                165                 170                 175     

Asn Ser Tyr Asn Arg Asp Val Leu Thr Lys Met Leu Asp Asp Asn His 
            180                 185                 190         

Leu Leu Ala His His Leu Phe Thr Ala Gln Pro His Ile Phe Val Ser 
        195                 200                 205             

Lys Thr Asn Pro Leu Ala Lys Lys Asp Lys Val Lys Leu Ser Asp Leu 
    210                 215                 220                 

Glu Asn Phe Pro Tyr Leu Ser Tyr Asp Gln Gly Thr His Asn Ser Phe 
225                 230                 235                 240 

Tyr Phe Ser Glu Glu Ile Leu Ser Gln Glu His His Lys Lys Ser Ile 
                245                 250                 255     

Val Val Ser Asp Arg Ala Thr Leu Phe Asn Leu Leu Ile Gly Leu Asp 
            260                 265                 270         

Gly Tyr Thr Ile Ala Thr Gly Ile Leu Asn Ser Asn Leu Asn Gly Asp 
        275                 280                 285             

Asn Ile Val Ser Ile Pro Leu Asp Ile Asp Asp Pro Ile Glu Leu Val 
    290                 295                 300                 

Tyr Ile Gln His Glu Lys Thr Ser Leu Ser Lys Met Gly Glu Arg Phe 
305                 310                 315                 320 

Ile Asp Tyr Leu Leu Glu Glu Val Gln Phe Asp Ser 
                325                 330         

<210>   1263
<211>   219
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1263
atgaaaacat tctatgatgt gcagcaattc ctcaaacgat ttggtattat tgtttacatg   60
ggaaaacgct tatatgatat tgaactgatg aagttggaac tatctcggat ttacgatgca   120
gggttgatgg ataaattaga ctatctagag gcagaagcag ttcttcgcag agagcacaag   180
gtagaattgg attatattga gaaaaatgga gaaaagaac                          219

<210>   1264
<211>   73
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902638 (6.E-38)

<400>   1264
Met Lys Thr Phe Tyr Asp Val Gln Gln Phe Leu Lys Arg Phe Gly Ile 
1               5                   10                  15      

Ile Val Tyr Met Gly Lys Arg Leu Tyr Asp Ile Glu Leu Met Lys Leu 
            20                  25                  30          

Glu Leu Ser Arg Ile Tyr Asp Ala Gly Leu Met Asp Lys Leu Asp Tyr 
        35                  40                  45              

Leu Glu Ala Glu Ala Val Leu Arg Arg Glu His Lys Val Glu Leu Asp 
    50                  55                  60                  

Tyr Ile Glu Lys Asn Gly Glu Lys Asn 
65                  70              

<210>   1265
<211>   378
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1265
atggttactt ggattttgtg ggcacttata ctagcaatgt tggcgtggat gggctttaac   60
tatcttcgta ttcgccgtgc ggctaaaatt gtggacaatg aggagtttga agccttgatt   120
cgtacgggtc aattgattga tttgcgcgac ccagcagaat tccacagaaa acatatcctt   180
ggtgcacgca atattccttc aagtcagttg aaaactagtc ttgcagccct tcgtaaagat   240
aaacctgtcc ttctctacga aaaccaacgt gcgcaacgag ttacaaatgc agctctttac   300
ttgaaaaaac aaggtttttc tgagatttat atcctttctt atggcttgga ttcttggaaa   360
gggaaagtga agactagc                                                 378

<210>   1266

<211>   126
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902639 (5.E-69)

<400>   1266
Met Val Thr Trp Ile Leu Trp Ala Leu Ile Leu Ala Met Leu Ala Trp 
1               5                   10                  15      

Met Gly Phe Asn Tyr Leu Arg Ile Arg Arg Ala Ala Lys Ile Val Asp 
            20                  25                  30          

Asn Glu Glu Phe Glu Ala Leu Ile Arg Thr Gly Gln Leu Ile Asp Leu 
        35                  40                  45              

Arg Asp Pro Ala Glu Phe His Arg Lys His Ile Leu Gly Ala Arg Asn 
    50                  55                  60                  

Ile Pro Ser Ser Gln Leu Lys Thr Ser Leu Ala Ala Leu Arg Lys Asp 
65                  70                  75                  80  

Lys Pro Val Leu Leu Tyr Glu Asn Gln Arg Ala Gln Arg Val Thr Asn 
                85                  90                  95      

Ala Ala Leu Tyr Leu Lys Lys Gln Gly Phe Ser Glu Ile Tyr Ile Leu 
            100                 105                 110         

Ser Tyr Gly Leu Asp Ser Trp Lys Gly Lys Val Lys Thr Ser 
        115                 120                 125     

<210>   1267
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1267
gtgggtatct tgtcgattat tcttggtttg ttatttccaa ttgtaggcct gattttgggt   60
atcataggat tggtcttggc tatttcatac caaaaagagt cacaattaga ctataaaata   120
gaaaagattc ttaatatctt aggaattgtg atttctgtag ttaactggat tgtagcaatc   180
gccttaattt ttcgg                                                    195

<210>   1268
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902640 (2.E-30)

<400>   1268
Met Gly Ile Leu Ser Ile Ile Leu Gly Leu Leu Phe Pro Ile Val Gly 
1               5                   10                  15      

Leu Ile Leu Gly Ile Ile Gly Leu Val Leu Ala Ile Ser Tyr Gln Lys 
            20                  25                  30          

Glu Ser Gln Leu Asp Tyr Lys Ile Glu Lys Ile Leu Asn Ile Leu Gly 
        35                  40                  45              

Ile Val Ile Ser Val Val Asn Trp Ile Val Ala Ile Ala Leu Ile Phe 
    50                  55                  60                  

Arg 
65  

<210>   1269
<211>   723
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1269
atgcgtttag ataatttatt agctcaagaa aaaatcagcc gaaaggccat gaagcaagca   60
ctcctcagag gggaaattct agtcgatggt tgcccagccc gctccctagc tcaaaatatc   120
gatacaggac tacaagaact cctttttcag gatcgaatca ttcaaggcta tgaacacacc   180
tatcttatgc ttcataaacc tgctggtgcc gttacagcca acaaagacaa ggaacttccg   240
accgtcatgg acctgcttcc atctaacatc cagtctgaca agctctatgc cgttggccga   300
ctggaccgag atacaacggg actcctcctc ttgaccgata acggtccctt gggctttcag   360
ctcctccatc cccaatatca tgtcgataag acttaccaag ttgaggttaa tggacttcta   420
acacctgacc atatccaaac ctttcaaaaa ggaattgtct ttttagatga cactgtctgt   480
aaacccgcaa aactagagat tctatctgca agtccctccc tcagtcaagc ctctatcacc   540
atttcagaag gaaaatttca tcaaatcaag aaaatgttcc tctcggttgg tgttaaggtg   600
actagcctca aaagaatcca atttggggac ttcacattga acccagattt agcagaaggt   660
aactaccgcc ctttgaacca aaaagagtta caaatcatta aaaactattt agagatgagt   720
cga                                                                 723

<210>   1270
<211>   241
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal small subunit pseudouridine synthase A (rsuA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902641 (e-132)

<400>   1270
Met Arg Leu Asp Asn Leu Leu Ala Gln Glu Lys Ile Ser Arg Lys Ala 
1               5                   10                  15      

Met Lys Gln Ala Leu Leu Arg Gly Glu Ile Leu Val Asp Gly Cys Pro 
            20                  25                  30          

Ala Arg Ser Leu Ala Gln Asn Ile Asp Thr Gly Leu Gln Glu Leu Leu 
        35                  40                  45              

Phe Gln Asp Arg Ile Ile Gln Gly Tyr Glu His Thr Tyr Leu Met Leu 
    50                  55                  60                  

His Lys Pro Ala Gly Ala Val Thr Ala Asn Lys Asp Lys Glu Leu Pro 
65                  70                  75                  80  

Thr Val Met Asp Leu Leu Pro Ser Asn Ile Gln Ser Asp Lys Leu Tyr 
                85                  90                  95      

Ala Val Gly Arg Leu Asp Arg Asp Thr Thr Gly Leu Leu Leu Leu Thr 
            100                 105                 110         

Asp Asn Gly Pro Leu Gly Phe Gln Leu Leu His Pro Gln Tyr His Val 
        115                 120                 125             

Asp Lys Thr Tyr Gln Val Glu Val Asn Gly Leu Leu Thr Pro Asp His 
    130                 135                 140                 

Ile Gln Thr Phe Gln Lys Gly Ile Val Phe Leu Asp Asp Thr Val Cys 
145                 150                 155                 160 

Lys Pro Ala Lys Leu Glu Ile Leu Ser Ala Ser Pro Ser Leu Ser Gln 
                165                 170                 175     

Ala Ser Ile Thr Ile Ser Glu Gly Lys Phe His Gln Ile Lys Lys Met 
            180                 185                 190         

Phe Leu Ser Val Gly Val Lys Val Thr Ser Leu Lys Arg Ile Gln Phe 

        195                 200                 205             

Gly Asp Phe Thr Leu Asn Pro Asp Leu Ala Glu Gly Asn Tyr Arg Pro 
    210                 215                 220                 

Leu Asn Gln Lys Glu Leu Gln Ile Ile Lys Asn Tyr Leu Glu Met Ser 
225                 230                 235                 240 

Arg 
    

<210>   1271
<211>   1860
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1271
ttgaatatta tagaggaaat catgacaaaa ttaagagaag atatccgtaa cattgcgatt   60
atcgcccacg ttgaccacgg taaaacaacc ctggttgacg aattattgaa acaatcagaa   120
acgcttgatg cacggactga attggcagag cgtgctatgg actcaaacga tatcgaaaaa   180
gagcgtggaa ttaccatcct tgctaaaaat actgccgttg cttacaacgg aactcgtatc   240
aacattatgg acacaccagg acacgcggac tttggtggag aagttgagcg tatcatgaaa   300
atggttgacg gtgttgtctt ggtcgtagat gcctatgaag gaaccatgcc acaaactcgt   360
ttcgtattga aaaaagcctt ggaacaagac cttgtcccaa tcgtggttgt taacaaaatc   420
gataagccat cagctcgtcc agcagaagta gtggatgaag tcttggaact tttcatcgag   480

cttggtgcag atgacgacca gcttgatttc ccagtggttt atgcttcagc gatcaacgga   540
acttcttcat tgtcagatga tccagctgac caagaagcga ctatggcacc aatctttgac   600
acgattatcg accatatccc agctccagta gataactcag atgagccttt gcagttccaa   660
gtgtcacttt tggactacaa tgacttcgtt ggacgtatcg gtatcggtcg tgtcttccgt   720
ggtacagtta aggttgggga ccaagttacc ctttctaaac ttgacggtac aactaaaaac   780
ttccgtgtta caaaactctt cggtttcttt ggtttggaac gtcgtgaaat ccaagaagcc   840
aaagcgggtg acttgattgc cgtttcaggt atggaagaca tctttgtcgg tgaaaccatc   900
actccgacag atgcagtaga agctcttcca atcctacaca tcgatgagcc aactcttcaa   960
atgactttct tggtcaacaa ctcaccattt gctggtaaag aaggtaaatg ggtaacttct   1020
cgtaaggtgg aagaacgctt gcaggcagaa ttgcaaacag acgtttccct tcgtgttgac   1080
ccaactgatt caccagataa atggactgtt tcaggacgtg gagaattgca cttgtcaatc   1140
cttatcgaaa caatgcgtcg tgagggctat gaacttcaag tatctcgtcc agaagttatc   1200
gtaaaagaaa tcgacggtat taaatgtgaa ccatttgaac gtgtacaaat cgacactcca   1260
gaagaatacc aagggtctgt tatccaaagc ctttctgaac gtaaaggtga aatgttggat   1320
atgatttcaa ctggtaatgg tcaaactcgt ttggtcttcc ttgttccagc gcgtggtttg   1380
attggatact caactgagtt cttatcaatg actcgtggtt acggtatcat gaaccatacc   1440
ttcgaccaat acttgccatt gattccaggg gaaattggtg gacgtcaccg tggtgccctt   1500
gtttctatcg atgctggtaa ggctacaact tactcaatca tgtctatcga agaacgtggt   1560
acgatctttg tcaacccagg tactgaggtt tatgaaggaa tgatcatcgg tgaaaactct   1620
cgtgaaaatg acttgacagt taacatcacg aaggcaaaac aaatgaccaa cgttcgttca   1680
gctactaagg accaaacagc tgttatcaag acgcctcgta tcttgacact tgaagagtct   1740
cttgagttct tgaacgacga tgagtacatg gaagtaacgc ctgagtctat ccgtttgcgt   1800
aaacaaatcc ttaacaaagc agagcgtgag aaagctaaca agaagaaaaa atcagctgaa   1860

<210>   1272
<211>   620
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   elongation factor Tu family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902642 (0.E+01)

<400>   1272
Met Asn Ile Ile Glu Glu Ile Met Thr Lys Leu Arg Glu Asp Ile Arg 
1               5                   10                  15      

Asn Ile Ala Ile Ile Ala His Val Asp His Gly Lys Thr Thr Leu Val 
            20                  25                  30          

Asp Glu Leu Leu Lys Gln Ser Glu Thr Leu Asp Ala Arg Thr Glu Leu 
        35                  40                  45              

Ala Glu Arg Ala Met Asp Ser Asn Asp Ile Glu Lys Glu Arg Gly Ile 
    50                  55                  60                  

Thr Ile Leu Ala Lys Asn Thr Ala Val Ala Tyr Asn Gly Thr Arg Ile 
65                  70                  75                  80  

Asn Ile Met Asp Thr Pro Gly His Ala Asp Phe Gly Gly Glu Val Glu 
                85                  90                  95      

Arg Ile Met Lys Met Val Asp Gly Val Val Leu Val Val Asp Ala Tyr 
            100                 105                 110         

Glu Gly Thr Met Pro Gln Thr Arg Phe Val Leu Lys Lys Ala Leu Glu 
        115                 120                 125             

Gln Asp Leu Val Pro Ile Val Val Val Asn Lys Ile Asp Lys Pro Ser 
    130                 135                 140                 

Ala Arg Pro Ala Glu Val Val Asp Glu Val Leu Glu Leu Phe Ile Glu 
145                 150                 155                 160 

Leu Gly Ala Asp Asp Asp Gln Leu Asp Phe Pro Val Val Tyr Ala Ser 
                165                 170                 175     

Ala Ile Asn Gly Thr Ser Ser Leu Ser Asp Asp Pro Ala Asp Gln Glu 
            180                 185                 190         

Ala Thr Met Ala Pro Ile Phe Asp Thr Ile Ile Asp His Ile Pro Ala 
        195                 200                 205             

Pro Val Asp Asn Ser Asp Glu Pro Leu Gln Phe Gln Val Ser Leu Leu 
    210                 215                 220                 

Asp Tyr Asn Asp Phe Val Gly Arg Ile Gly Ile Gly Arg Val Phe Arg 
225                 230                 235                 240 

Gly Thr Val Lys Val Gly Asp Gln Val Thr Leu Ser Lys Leu Asp Gly 
                245                 250                 255     

Thr Thr Lys Asn Phe Arg Val Thr Lys Leu Phe Gly Phe Phe Gly Leu 
            260                 265                 270         

Glu Arg Arg Glu Ile Gln Glu Ala Lys Ala Gly Asp Leu Ile Ala Val 
        275                 280                 285             

Ser Gly Met Glu Asp Ile Phe Val Gly Glu Thr Ile Thr Pro Thr Asp 
    290                 295                 300                 

Ala Val Glu Ala Leu Pro Ile Leu His Ile Asp Glu Pro Thr Leu Gln 
305                 310                 315                 320 

Met Thr Phe Leu Val Asn Asn Ser Pro Phe Ala Gly Lys Glu Gly Lys 
                325                 330                 335     

Trp Val Thr Ser Arg Lys Val Glu Glu Arg Leu Gln Ala Glu Leu Gln 
            340                 345                 350         

Thr Asp Val Ser Leu Arg Val Asp Pro Thr Asp Ser Pro Asp Lys Trp 
        355                 360                 365             

Thr Val Ser Gly Arg Gly Glu Leu His Leu Ser Ile Leu Ile Glu Thr 
    370                 375                 380                 

Met Arg Arg Glu Gly Tyr Glu Leu Gln Val Ser Arg Pro Glu Val Ile 
385                 390                 395                 400 

Val Lys Glu Ile Asp Gly Ile Lys Cys Glu Pro Phe Glu Arg Val Gln 
                405                 410                 415     

Ile Asp Thr Pro Glu Glu Tyr Gln Gly Ser Val Ile Gln Ser Leu Ser 
            420                 425                 430         

Glu Arg Lys Gly Glu Met Leu Asp Met Ile Ser Thr Gly Asn Gly Gln 
        435                 440                 445             

Thr Arg Leu Val Phe Leu Val Pro Ala Arg Gly Leu Ile Gly Tyr Ser 
    450                 455                 460                 

Thr Glu Phe Leu Ser Met Thr Arg Gly Tyr Gly Ile Met Asn His Thr 
465                 470                 475                 480 

Phe Asp Gln Tyr Leu Pro Leu Ile Pro Gly Glu Ile Gly Gly Arg His 
                485                 490                 495     

Arg Gly Ala Leu Val Ser Ile Asp Ala Gly Lys Ala Thr Thr Tyr Ser 
            500                 505                 510         

Ile Met Ser Ile Glu Glu Arg Gly Thr Ile Phe Val Asn Pro Gly Thr 
        515                 520                 525             

Glu Val Tyr Glu Gly Met Ile Ile Gly Glu Asn Ser Arg Glu Asn Asp 
    530                 535                 540                 

Leu Thr Val Asn Ile Thr Lys Ala Lys Gln Met Thr Asn Val Arg Ser 
545                 550                 555                 560 

Ala Thr Lys Asp Gln Thr Ala Val Ile Lys Thr Pro Arg Ile Leu Thr 
                565                 570                 575     

Leu Glu Glu Ser Leu Glu Phe Leu Asn Asp Asp Glu Tyr Met Glu Val 
            580                 585                 590         

Thr Pro Glu Ser Ile Arg Leu Arg Lys Gln Ile Leu Asn Lys Ala Glu 
        595                 600                 605             

Arg Glu Lys Ala Asn Lys Lys Lys Lys Ser Ala Glu 
    610                 615                 620 

<210>   1273
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1273
atggtctatt tagtcctagg aattttactg ctcctactct atgtatttgc gacaccagaa   60
agcattaaag ggactgtcaa tatcgtcgct atggtatgta ttttagtggc actcttgatt   120
ttattggttc tatcttttct gaaaattttt caattaccaa cagaaatatt cctagcaata   180
gccatgttga tcctagctta ctttagtgtt agagacatca cactcatgcc agtcaaaaaa   240
agtaaaagaa ga                                                       252

<210>   1274
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902643 (1.E-40)

<400>   1274
Met Val Tyr Leu Val Leu Gly Ile Leu Leu Leu Leu Leu Tyr Val Phe 
1               5                   10                  15      

Ala Thr Pro Glu Ser Ile Lys Gly Thr Val Asn Ile Val Ala Met Val 
            20                  25                  30          

Cys Ile Leu Val Ala Leu Leu Ile Leu Leu Val Leu Ser Phe Leu Lys 
        35                  40                  45              

Ile Phe Gln Leu Pro Thr Glu Ile Phe Leu Ala Ile Ala Met Leu Ile 
    50                  55                  60                  

Leu Ala Tyr Phe Ser Val Arg Asp Ile Thr Leu Met Pro Val Lys Lys 
65                  70                  75                  80  

Ser Lys Arg Arg 
                

<210>   1275
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1275
ttgaaaccgc tttcttatgt gataagaata acttttttat tatttgttgt caaggaaaaa   60
atcgaatttt ttagatattt tactatatta cctctg                             96

<210>   1276
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1276
Met Lys Pro Leu Ser Tyr Val Ile Arg Ile Thr Phe Leu Leu Phe Val 
1               5                   10                  15      

Val Lys Glu Lys Ile Glu Phe Phe Arg Tyr Phe Thr Ile Leu Pro Leu 
            20                  25                  30          


<210>   1277
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1277
atggaggagt atggacatat ggagaaggtt caggaggtgg ttaggctttt tcaaattact   60
atcatggtaa aaaatatcat tattcatcta tcg                                93

<210>   1278
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1278
Met Glu Glu Tyr Gly His Met Glu Lys Val Gln Glu Val Val Arg Leu 
1               5                   10                  15      

Phe Gln Ile Thr Ile Met Val Lys Asn Ile Ile Ile His Leu Ser 
            20                  25                  30      

<210>   1279
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1279
gtgagcagat gggatggtca ttctgataaa ggagaagctc ctgctggaaa acctcctatg   60
catggatttg gactaaatgg ggagaacaag                                    90

<210>   1280
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902644 (9.E-06)

<400>   1280
Met Ser Arg Trp Asp Gly His Ser Asp Lys Gly Glu Ala Pro Ala Gly 
1               5                   10                  15      

Lys Pro Pro Met His Gly Phe Gly Leu Asn Gly Glu Asn Lys 
            20                  25                  30  

<210>   1281
<211>   2019
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1281
atgaagaaac tattcatatt attatcaact ttttttctca gcttcttcct tgcttggatt   60
attgtcttac gtgcgccaca atatttatat gcaagctatg attccgtttc tttacttcgt   120
gtcaaaaaag atactcagga accgacgcgt gaggtatttg aacaggaatt ggagaatttt   180
gcaaactcag aacagagttt aatagctaga agaattgtag agccgagtaa ggatgggacg   240
actcacttta cttatgcaac ttatggtcag ggaactttac caaaagaatt ccaagaagct   300
agccaagaaa gtcgtgaacg tagtgatccg ctaaatagtt atctcctttt gtcaggctcc   360
ttgacgaaag aaaagcttgc cgataaatta ggagatttgg gttataaagc aagtgctgac   420
cgaaagatac cgccctattt tcttgctttt cgaatattac taaatcccct tattttaatt   480
agtttagcaa tatttggctt atctttcttt gctttagtga ttatcactcg gattaaggaa   540
atgagagcag caggtataaa actcttttct ggtcagactc tcttatccat catggggcat   600
tctttatcta ctgatatcaa atggctcctt ctatcagccc tcctttcctt cctaggtggg   660
ggagtcgttc tttttagtca aggtttgttt tatcctatct tgttagccac ctatggtttt   720
gggattagtt tctatctgtt gtttttattg gcgatttcaa ttttactaat gctcctttac   780
ctaatgagtt tgagttacaa agcattagtt cccgttatta agggaagatt accccttaaa   840
cgcttgatgg ctttaaccct attgtgtcag ttagtagctg tttttacagt aggctacgct   900
gttaagacag gtttgacgtc ttaccaacga ttgaaagaac ttgaaatttc aaaacaagca   960
tggcaggaca gagcagacta ttaccagatt tcctttggct taggtgatag aggaaaagat   1020
acagaaaatc agagcaagtg gtatgccttt gccaaggaag caatcgaaga agaacaagct   1080
ctttatgtaa aggataatct gctccatttt gccaatccac aaggaaaaaa tgaacaggga   1140
gagacactgg atacctatag ttcagatgct aatacgctct atgttagtcc cagttatttg   1200
gacaaggaaa aggtcgtggt agatgctgag accaaacaga agttagccca tctccaaaaa   1260
ggtgagttta tcctcttgct cccagaacat ttgcgctctc gagaagcaga acttaagaaa   1320
gtttttgaag aaagattgag ttattatgga aaatctggtg aggaggcaag tgctcctttg   1380
gattatgaga tgaaagcgca cgttagttat ctttcaatgg gagaaaagcg gtttgtttat   1440
aataacggtg agaatcccgt atctactcag tatttgactg atccgatttt agtggtattc   1500
acgccgactt ctacaggtga tagttttata tccttatcta gttggtctat caatgctgga   1560
aaacaactct ttatcaaagg atatgagagt gggctagaac tcttgaagaa agctggaatt   1620
tatgagcaag tatcctatct taaagaagga agaagtgttt atctaactcg ttataatgaa   1680
gttcaaactg aaacagcaac tttaatctta ggagctattg ttggaatagc cagttccttg   1740
ttactctttt attctgtcaa tcttctatat ttcgagcaat tccgccgaga tatcttgatt   1800
aaacgaattt caggtttacg attttttgaa acacatgctc agtatatggt tagccaattt   1860
gctagttttg tatttggtgc tagtctcttt attttaagca gtcgagactt ggtgattggc   1920
ttgctcactt tattggtctt tctagctagt gcagttttga cgctttaccg tcaagcgcag   1980
aaagaatctc gtgtttctat gacaattatg aaaggaaaa                          2019

<210>   1282
<211>   673
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902645 (0.E+01)

<400>   1282
Met Lys Lys Leu Phe Ile Leu Leu Ser Thr Phe Phe Leu Ser Phe Phe 
1               5                   10                  15      

Leu Ala Trp Ile Ile Val Leu Arg Ala Pro Gln Tyr Leu Tyr Ala Ser 
            20                  25                  30          

Tyr Asp Ser Val Ser Leu Leu Arg Val Lys Lys Asp Thr Gln Glu Pro 
        35                  40                  45              

Thr Arg Glu Val Phe Glu Gln Glu Leu Glu Asn Phe Ala Asn Ser Glu 
    50                  55                  60                  

Gln Ser Leu Ile Ala Arg Arg Ile Val Glu Pro Ser Lys Asp Gly Thr 
65                  70                  75                  80  

Thr His Phe Thr Tyr Ala Thr Tyr Gly Gln Gly Thr Leu Pro Lys Glu 
                85                  90                  95      

Phe Gln Glu Ala Ser Gln Glu Ser Arg Glu Arg Ser Asp Pro Leu Asn 
            100                 105                 110         

Ser Tyr Leu Leu Leu Ser Gly Ser Leu Thr Lys Glu Lys Leu Ala Asp 
        115                 120                 125             

Lys Leu Gly Asp Leu Gly Tyr Lys Ala Ser Ala Asp Arg Lys Ile Pro 
    130                 135                 140                 

Pro Tyr Phe Leu Ala Phe Arg Ile Leu Leu Asn Pro Leu Ile Leu Ile 
145                 150                 155                 160 

Ser Leu Ala Ile Phe Gly Leu Ser Phe Phe Ala Leu Val Ile Ile Thr 
                165                 170                 175     

Arg Ile Lys Glu Met Arg Ala Ala Gly Ile Lys Leu Phe Ser Gly Gln 
            180                 185                 190         

Thr Leu Leu Ser Ile Met Gly His Ser Leu Ser Thr Asp Ile Lys Trp 
        195                 200                 205             

Leu Leu Leu Ser Ala Leu Leu Ser Phe Leu Gly Gly Gly Val Val Leu 
    210                 215                 220                 

Phe Ser Gln Gly Leu Phe Tyr Pro Ile Leu Leu Ala Thr Tyr Gly Phe 
225                 230                 235                 240 

Gly Ile Ser Phe Tyr Leu Leu Phe Leu Leu Ala Ile Ser Ile Leu Leu 
                245                 250                 255     

Met Leu Leu Tyr Leu Met Ser Leu Ser Tyr Lys Ala Leu Val Pro Val 
            260                 265                 270         

Ile Lys Gly Arg Leu Pro Leu Lys Arg Leu Met Ala Leu Thr Leu Leu 
        275                 280                 285             

Cys Gln Leu Val Ala Val Phe Thr Val Gly Tyr Ala Val Lys Thr Gly 
    290                 295                 300                 

Leu Thr Ser Tyr Gln Arg Leu Lys Glu Leu Glu Ile Ser Lys Gln Ala 
305                 310                 315                 320 

Trp Gln Asp Arg Ala Asp Tyr Tyr Gln Ile Ser Phe Gly Leu Gly Asp 
                325                 330                 335     

Arg Gly Lys Asp Thr Glu Asn Gln Ser Lys Trp Tyr Ala Phe Ala Lys 
            340                 345                 350         

Glu Ala Ile Glu Glu Glu Gln Ala Leu Tyr Val Lys Asp Asn Leu Leu 
        355                 360                 365             

His Phe Ala Asn Pro Gln Gly Lys Asn Glu Gln Gly Glu Thr Leu Asp 
    370                 375                 380                 

Thr Tyr Ser Ser Asp Ala Asn Thr Leu Tyr Val Ser Pro Ser Tyr Leu 
385                 390                 395                 400 

Asp Lys Glu Lys Val Val Val Asp Ala Glu Thr Lys Gln Lys Leu Ala 
                405                 410                 415     

His Leu Gln Lys Gly Glu Phe Ile Leu Leu Leu Pro Glu His Leu Arg 
            420                 425                 430         

Ser Arg Glu Ala Glu Leu Lys Lys Val Phe Glu Glu Arg Leu Ser Tyr 
        435                 440                 445             

Tyr Gly Lys Ser Gly Glu Glu Ala Ser Ala Pro Leu Asp Tyr Glu Met 
    450                 455                 460                 

Lys Ala His Val Ser Tyr Leu Ser Met Gly Glu Lys Arg Phe Val Tyr 
465                 470                 475                 480 

Asn Asn Gly Glu Asn Pro Val Ser Thr Gln Tyr Leu Thr Asp Pro Ile 
                485                 490                 495     

Leu Val Val Phe Thr Pro Thr Ser Thr Gly Asp Ser Phe Ile Ser Leu 
            500                 505                 510         

Ser Ser Trp Ser Ile Asn Ala Gly Lys Gln Leu Phe Ile Lys Gly Tyr 
        515                 520                 525             

Glu Ser Gly Leu Glu Leu Leu Lys Lys Ala Gly Ile Tyr Glu Gln Val 
    530                 535                 540                 

Ser Tyr Leu Lys Glu Gly Arg Ser Val Tyr Leu Thr Arg Tyr Asn Glu 
545                 550                 555                 560 

Val Gln Thr Glu Thr Ala Thr Leu Ile Leu Gly Ala Ile Val Gly Ile 
                565                 570                 575     

Ala Ser Ser Leu Leu Leu Phe Tyr Ser Val Asn Leu Leu Tyr Phe Glu 
            580                 585                 590         

Gln Phe Arg Arg Asp Ile Leu Ile Lys Arg Ile Ser Gly Leu Arg Phe 
        595                 600                 605             

Phe Glu Thr His Ala Gln Tyr Met Val Ser Gln Phe Ala Ser Phe Val 
    610                 615                 620                 

Phe Gly Ala Ser Leu Phe Ile Leu Ser Ser Arg Asp Leu Val Ile Gly 
625                 630                 635                 640 

Leu Leu Thr Leu Leu Val Phe Leu Ala Ser Ala Val Leu Thr Leu Tyr 
                645                 650                 655     

Arg Gln Ala Gln Lys Glu Ser Arg Val Ser Met Thr Ile Met Lys Gly 
            660                 665                 670         

Lys 
    

<210>   1283
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1283
atgattgaac taaagaatat atctaaaaaa tttggaagcc gtcagctatt ttcagatatg   60
aatcttcatt ttgaaggtgg gaaaatttat gccttaatcg gtacaagtgg ctgtggtaag   120
acaacactct tgaatatgat tggacgattg gagccatatg acaaagggca aatcatctat   180
gatggcactt ctcttaagga catcaagcct tctgttttct ttagagatta cttaggatac   240
ttatttcaag attttggctt aattgaaagc caaaccgtca aagagaatct caatctgggt   300
ttagttggta aaaagttgaa ggaaaaagag aaaatctctt tgatgaaaca agctctaaac   360
cgtgtaaacc tctcttattt ggatttgaag caacctatat ttgagttatc aggaggagaa   420
gcacaacgtg ttgcactagc gaagataatt ttaaaggatc cacctttgat cctcgcagat   480
gaaccaaccg cttccttaga ccccaaaaac tctgaggaat tactttccat cctagaatct   540
ttaaaaaatc cgaatcggac cattattatt gcgacccata atcctctgat ttgggagcaa   600
gtggatcagg tcattcgagt taccgattta tcacataga                          639

<210>   1284
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902646 (e-118)

<400>   1284
Met Ile Glu Leu Lys Asn Ile Ser Lys Lys Phe Gly Ser Arg Gln Leu 
1               5                   10                  15      

Phe Ser Asp Met Asn Leu His Phe Glu Gly Gly Lys Ile Tyr Ala Leu 
            20                  25                  30          

Ile Gly Thr Ser Gly Cys Gly Lys Thr Thr Leu Leu Asn Met Ile Gly 
        35                  40                  45              

Arg Leu Glu Pro Tyr Asp Lys Gly Gln Ile Ile Tyr Asp Gly Thr Ser 
    50                  55                  60                  

Leu Lys Asp Ile Lys Pro Ser Val Phe Phe Arg Asp Tyr Leu Gly Tyr 
65                  70                  75                  80  

Leu Phe Gln Asp Phe Gly Leu Ile Glu Ser Gln Thr Val Lys Glu Asn 
                85                  90                  95      

Leu Asn Leu Gly Leu Val Gly Lys Lys Leu Lys Glu Lys Glu Lys Ile 
            100                 105                 110         

Ser Leu Met Lys Gln Ala Leu Asn Arg Val Asn Leu Ser Tyr Leu Asp 
        115                 120                 125             

Leu Lys Gln Pro Ile Phe Glu Leu Ser Gly Gly Glu Ala Gln Arg Val 
    130                 135                 140                 

Ala Leu Ala Lys Ile Ile Leu Lys Asp Pro Pro Leu Ile Leu Ala Asp 
145                 150                 155                 160 

Glu Pro Thr Ala Ser Leu Asp Pro Lys Asn Ser Glu Glu Leu Leu Ser 
                165                 170                 175     

Ile Leu Glu Ser Leu Lys Asn Pro Asn Arg Thr Ile Ile Ile Ala Thr 
            180                 185                 190         

His Asn Pro Leu Ile Trp Glu Gln Val Asp Gln Val Ile Arg Val Thr 
        195                 200                 205             

Asp Leu Ser His Arg 
    210             

<210>   1285
<211>   1350
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1285
atgaaagtaa tagatcaatt taaaaataag aaagtccttg ttttaggttt ggccaagtct   60
ggtgaatctg cagctcgttt gttggacaag ctaggtgcca ttgtgacagt aaatgatggg   120
aaacctttcg aggacaatcc agctgcccaa agtttgctgg aagaagggat caaggtcatt   180
acaggtggcc atcctttgga actcttggat gaagagtttg cccttatggt gaaaaatcca   240
ggtatcccct acaacaatcc catgattgaa aaggctttgg ccaagggaat tccagtcttg   300
actgaggtgg aattggctta tttgatttca gaagcaccga ttattggtat cacaggatcg   360
aacggtaaga caaccacaac gactatgatt ggggaagttt tgactgctgc tggccaacat   420
ggtcttttat cagggaatat cggctatcca gctagtcagg ttgctcaaat agcatcagat   480
aaggacacgc ttgttatgga actttcttct ttccaactca tgggtgttca agaattccat   540
ccagagattg cggttattac caacctcatg ccaactcata tcgactacca tgggtcattt   600
tcggaatatg tagcagccaa gtggaatatc cagaacaaga tgacagcagc tgatttcctt   660
gtcttgaact ttaatcaaga cttggcaaaa gacttgactt ccaagacaga agccactgtt   720
gtaccatttt caacacttga aaaggttgat ggagcttatc tggaagatgg tcaactctac   780
ttccgtggtg aagtagtcat ggcagcgaat gaaatcggtg ttccaggtag ccacaatgtg   840
gaaaatgccc ttgcgactat tgctgtagcc aagcttcgtg atgtggacaa tcaaaccatc   900
aaggaaactc tttcagcctt cggtggtgtc aaacaccgtc tccagtttgt ggatgacatc   960
aagggtgtta aattctataa cgacagtaaa tcaactaata tcttggctac tcaaaaagcc   1020
ttgtcaggat ttgacaacag caaggtcgtc ttgattgcag gtggtttgga ccgtggcaat   1080
gagtttgacg aattggtgcc agacattact ggactcaaga agatggtcat cctgggtcaa   1140
tctgcagaac gtgtcaaacg ggcagcagac aaggctggtg tcgcttatgt ggaggcgaca   1200
gatattgcag atgcgacccg caaggcctat gagcttgcga ctcaaggaga tgtggttctt   1260
cttagtcctg ccaatgctag ctgggatatg tatgctaact ttgaagtacg tggcgacctc   1320
tttatcgaca cagtagcgga gttaaaagaa                                    1350

<210>   1286
<211>   450
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902647 (0.E+01)

<400>   1286
Met Lys Val Ile Asp Gln Phe Lys Asn Lys Lys Val Leu Val Leu Gly 
1               5                   10                  15      

Leu Ala Lys Ser Gly Glu Ser Ala Ala Arg Leu Leu Asp Lys Leu Gly 
            20                  25                  30          

Ala Ile Val Thr Val Asn Asp Gly Lys Pro Phe Glu Asp Asn Pro Ala 
        35                  40                  45              

Ala Gln Ser Leu Leu Glu Glu Gly Ile Lys Val Ile Thr Gly Gly His 
    50                  55                  60                  

Pro Leu Glu Leu Leu Asp Glu Glu Phe Ala Leu Met Val Lys Asn Pro 
65                  70                  75                  80  

Gly Ile Pro Tyr Asn Asn Pro Met Ile Glu Lys Ala Leu Ala Lys Gly 
                85                  90                  95      

Ile Pro Val Leu Thr Glu Val Glu Leu Ala Tyr Leu Ile Ser Glu Ala 
            100                 105                 110         

Pro Ile Ile Gly Ile Thr Gly Ser Asn Gly Lys Thr Thr Thr Thr Thr 
        115                 120                 125             

Met Ile Gly Glu Val Leu Thr Ala Ala Gly Gln His Gly Leu Leu Ser 
    130                 135                 140                 

Gly Asn Ile Gly Tyr Pro Ala Ser Gln Val Ala Gln Ile Ala Ser Asp 
145                 150                 155                 160 

Lys Asp Thr Leu Val Met Glu Leu Ser Ser Phe Gln Leu Met Gly Val 
                165                 170                 175     

Gln Glu Phe His Pro Glu Ile Ala Val Ile Thr Asn Leu Met Pro Thr 
            180                 185                 190         

His Ile Asp Tyr His Gly Ser Phe Ser Glu Tyr Val Ala Ala Lys Trp 
        195                 200                 205             

Asn Ile Gln Asn Lys Met Thr Ala Ala Asp Phe Leu Val Leu Asn Phe 
    210                 215                 220                 

Asn Gln Asp Leu Ala Lys Asp Leu Thr Ser Lys Thr Glu Ala Thr Val 
225                 230                 235                 240 

Val Pro Phe Ser Thr Leu Glu Lys Val Asp Gly Ala Tyr Leu Glu Asp 
                245                 250                 255     

Gly Gln Leu Tyr Phe Arg Gly Glu Val Val Met Ala Ala Asn Glu Ile 
            260                 265                 270         

Gly Val Pro Gly Ser His Asn Val Glu Asn Ala Leu Ala Thr Ile Ala 
        275                 280                 285             

Val Ala Lys Leu Arg Asp Val Asp Asn Gln Thr Ile Lys Glu Thr Leu 
    290                 295                 300                 

Ser Ala Phe Gly Gly Val Lys His Arg Leu Gln Phe Val Asp Asp Ile 
305                 310                 315                 320 

Lys Gly Val Lys Phe Tyr Asn Asp Ser Lys Ser Thr Asn Ile Leu Ala 
                325                 330                 335     

Thr Gln Lys Ala Leu Ser Gly Phe Asp Asn Ser Lys Val Val Leu Ile 
            340                 345                 350         

Ala Gly Gly Leu Asp Arg Gly Asn Glu Phe Asp Glu Leu Val Pro Asp 
        355                 360                 365             

Ile Thr Gly Leu Lys Lys Met Val Ile Leu Gly Gln Ser Ala Glu Arg 
    370                 375                 380                 

Val Lys Arg Ala Ala Asp Lys Ala Gly Val Ala Tyr Val Glu Ala Thr 
385                 390                 395                 400 

Asp Ile Ala Asp Ala Thr Arg Lys Ala Tyr Glu Leu Ala Thr Gln Gly 
                405                 410                 415     

Asp Val Val Leu Leu Ser Pro Ala Asn Ala Ser Trp Asp Met Tyr Ala 
            420                 425                 430         

Asn Phe Glu Val Arg Gly Asp Leu Phe Ile Asp Thr Val Ala Glu Leu 
        435                 440                 445             

Lys Glu 
    450 

<210>   1287
<211>   1056
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1287
atgaaaaaaa ttgtctttac aggtgggggg acggttggac acgttaccct caatcttttg   60
ttaatgccca agttcatcga agatggttgg gaagtccact atatcgggga caagtgtggt   120
atcgaacacc aagaaatcct taagtcaggt ttggatgtca ccttccattc tattgcgact   180
ggaaaattgc gtcgctattt ctcttggcaa aatatgctgg acgtcttcaa agttggttgg   240
ggaattgtcc aatcgctctt tatcatgttg cgactgcgtc cacagaccct tttttcaaag   300
gggggctttg tctcagtacc gcctgttatc gctgcgcgtg tgtcaggagt gcctgtcttt   360
attcacgaat ctgacctgtc tatgggcttg gccaataaaa tcgcctataa atttgcgact   420
aagatgtatt caacctttga acaagcttcg agtttggcta aggttgagca tgtgggagcg   480
gtgaccaagg tttcggacaa aaacactcca gaaccagatg aattggtgga tattcaaacc   540
cactttaatc ccaaattgcc aactgtattg tttgttggcg gttctgcagg cgctcgtgtc   600
tttaaccaat tggtgacaga ccataagaaa gaactaacag agcgctacaa tattatcaat   660
ctaactggag attctagtct gaatgagttg aggcaaaatc tttttcgtgt tgactatgtg   720
accgatctct atcaaccctt gatggaattg gctgatattg ttgtgacacg aggtggtgcc   780
aatacgattt ttgagctctt ggcgatagca aaattgcatg tcattgtgcc gcttggtcgt   840
gaagctagtc gtggtgacca gattgaaaat gcagcttact ttgttaagaa aggctatgca   900
gaagaccttc aagaaagcga tttgaccttg gatagtttgg aagagaagct ttctcactta   960
ctaagtcaca aggaagatta ccaagctaag atgaaagctt ctaaggaatt gaaatctcta   1020
gcagattttt atcaattgtt gaaaaaagat ttatca                             1056

<210>   1288
<211>   352
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902648 (0.E+01)

<400>   1288
Met Lys Lys Ile Val Phe Thr Gly Gly Gly Thr Val Gly His Val Thr 
1               5                   10                  15      

Leu Asn Leu Leu Leu Met Pro Lys Phe Ile Glu Asp Gly Trp Glu Val 
            20                  25                  30          

His Tyr Ile Gly Asp Lys Cys Gly Ile Glu His Gln Glu Ile Leu Lys 
        35                  40                  45              

Ser Gly Leu Asp Val Thr Phe His Ser Ile Ala Thr Gly Lys Leu Arg 
    50                  55                  60                  

Arg Tyr Phe Ser Trp Gln Asn Met Leu Asp Val Phe Lys Val Gly Trp 
65                  70                  75                  80  

Gly Ile Val Gln Ser Leu Phe Ile Met Leu Arg Leu Arg Pro Gln Thr 
                85                  90                  95      

Leu Phe Ser Lys Gly Gly Phe Val Ser Val Pro Pro Val Ile Ala Ala 
            100                 105                 110         

Arg Val Ser Gly Val Pro Val Phe Ile His Glu Ser Asp Leu Ser Met 
        115                 120                 125             

Gly Leu Ala Asn Lys Ile Ala Tyr Lys Phe Ala Thr Lys Met Tyr Ser 
    130                 135                 140                 

Thr Phe Glu Gln Ala Ser Ser Leu Ala Lys Val Glu His Val Gly Ala 
145                 150                 155                 160 

Val Thr Lys Val Ser Asp Lys Asn Thr Pro Glu Pro Asp Glu Leu Val 
                165                 170                 175     

Asp Ile Gln Thr His Phe Asn Pro Lys Leu Pro Thr Val Leu Phe Val 
            180                 185                 190         

Gly Gly Ser Ala Gly Ala Arg Val Phe Asn Gln Leu Val Thr Asp His 
        195                 200                 205             

Lys Lys Glu Leu Thr Glu Arg Tyr Asn Ile Ile Asn Leu Thr Gly Asp 
    210                 215                 220                 

Ser Ser Leu Asn Glu Leu Arg Gln Asn Leu Phe Arg Val Asp Tyr Val 
225                 230                 235                 240 

Thr Asp Leu Tyr Gln Pro Leu Met Glu Leu Ala Asp Ile Val Val Thr 
                245                 250                 255     

Arg Gly Gly Ala Asn Thr Ile Phe Glu Leu Leu Ala Ile Ala Lys Leu 
            260                 265                 270         


His Val Ile Val Pro Leu Gly Arg Glu Ala Ser Arg Gly Asp Gln Ile 
        275                 280                 285             

Glu Asn Ala Ala Tyr Phe Val Lys Lys Gly Tyr Ala Glu Asp Leu Gln 
    290                 295                 300                 

Glu Ser Asp Leu Thr Leu Asp Ser Leu Glu Glu Lys Leu Ser His Leu 
305                 310                 315                 320 

Leu Ser His Lys Glu Asp Tyr Gln Ala Lys Met Lys Ala Ser Lys Glu 
                325                 330                 335     

Leu Lys Ser Leu Ala Asp Phe Tyr Gln Leu Leu Lys Lys Asp Leu Ser 
            340                 345                 350         


<210>   1289
<211>   1197
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1289
atgtcaaaag ataagaaaaa tgaggacaaa gaaaccctcg aagaattgaa agagttatca   60
gaatggcaga aacgaaacca agaatatcta aaaaagaagg ctgaagaaga ggcggctcta   120
gctgaggaga aggaaaagga aagacaagct cgaatgggag aagaatctga gaagtcagag   180
gataaacagg accaggagag tgaaacagac caggaagatt cagaatcagc taaggaagag   240
tctgaagaaa aagtagcatc ctcagaggct gacaaagaga aagaagagaa agaagaacca   300
gagtctaaag agaaggagga acaggataaa aagcttgcta aaaaggctac aaaggaaaaa   360
ccagccaaag caaagattcc tggtatccat atcttgcgag ccttcacgat tttatttcca   420
agtctgcttc tattgtttgt ctctgcctac ttgctcagtc cttatgcgac catgaaagat   480
attcgtgttg agggaacggt gcaaactaca gctgatgata ttcgacaggc ttcaggcatt   540
caggattcgg attatacgat taaccttctg ctagacaagg caaaatatga aaagcagatt   600
aagtctaact attgggttga atcagctcaa cttgtctatc aatttccaac taagttcact   660
attaaggtca aggaatatga tattgtggcc tactatattt ctggtgaaaa tcattatcct   720
attctttcca gtggtcagct tgagactagt tctgtgagtc tgaacagttt accagaaact   780
tatttatcag ttctctttaa tgatagtgaa caaatcaaag tttttgtctc agaacttgct   840
caaattagcc cagaactcaa ggcggctatc caaaaggtgg aattagcccc aagcaaggtg   900
acatccgatt taattcgatt gaccatgaat gattcggacg aagtcttggt tcctctatct   960
gaaatgagta agaaactgcc atattacagt aagattaagc ctcaattgtc agaaccgagt   1020
gtggtcgaca tggaagctgg aatctacagc tacactgtgg cggataaatt aattatggaa   1080
gctgaggaaa aagccaaaca agaggccaag gaagctgaga aaaaacaaga agaagaacag   1140
aaaaaacaag aggaagagag caatcgaaac caaacgaccc agcgttcatc gcgtcgc      1197

<210>   1290
<211>   399
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   cell division protein DivIB (divIB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902649 (0.E+01)

<400>   1290
Met Ser Lys Asp Lys Lys Asn Glu Asp Lys Glu Thr Leu Glu Glu Leu 
1               5                   10                  15      

Lys Glu Leu Ser Glu Trp Gln Lys Arg Asn Gln Glu Tyr Leu Lys Lys 
            20                  25                  30          

Lys Ala Glu Glu Glu Ala Ala Leu Ala Glu Glu Lys Glu Lys Glu Arg 
        35                  40                  45              

Gln Ala Arg Met Gly Glu Glu Ser Glu Lys Ser Glu Asp Lys Gln Asp 
    50                  55                  60                  

Gln Glu Ser Glu Thr Asp Gln Glu Asp Ser Glu Ser Ala Lys Glu Glu 
65                  70                  75                  80  

Ser Glu Glu Lys Val Ala Ser Ser Glu Ala Asp Lys Glu Lys Glu Glu 
                85                  90                  95      

Lys Glu Glu Pro Glu Ser Lys Glu Lys Glu Glu Gln Asp Lys Lys Leu 
            100                 105                 110         

Ala Lys Lys Ala Thr Lys Glu Lys Pro Ala Lys Ala Lys Ile Pro Gly 
        115                 120                 125             

Ile His Ile Leu Arg Ala Phe Thr Ile Leu Phe Pro Ser Leu Leu Leu 
    130                 135                 140                 

Leu Phe Val Ser Ala Tyr Leu Leu Ser Pro Tyr Ala Thr Met Lys Asp 
145                 150                 155                 160 

Ile Arg Val Glu Gly Thr Val Gln Thr Thr Ala Asp Asp Ile Arg Gln 
                165                 170                 175     

Ala Ser Gly Ile Gln Asp Ser Asp Tyr Thr Ile Asn Leu Leu Leu Asp 
            180                 185                 190         

Lys Ala Lys Tyr Glu Lys Gln Ile Lys Ser Asn Tyr Trp Val Glu Ser 
        195                 200                 205             

Ala Gln Leu Val Tyr Gln Phe Pro Thr Lys Phe Thr Ile Lys Val Lys 
    210                 215                 220                 

Glu Tyr Asp Ile Val Ala Tyr Tyr Ile Ser Gly Glu Asn His Tyr Pro 
225                 230                 235                 240 

Ile Leu Ser Ser Gly Gln Leu Glu Thr Ser Ser Val Ser Leu Asn Ser 
                245                 250                 255     

Leu Pro Glu Thr Tyr Leu Ser Val Leu Phe Asn Asp Ser Glu Gln Ile 
            260                 265                 270         

Lys Val Phe Val Ser Glu Leu Ala Gln Ile Ser Pro Glu Leu Lys Ala 
        275                 280                 285             

Ala Ile Gln Lys Val Glu Leu Ala Pro Ser Lys Val Thr Ser Asp Leu 
    290                 295                 300                 

Ile Arg Leu Thr Met Asn Asp Ser Asp Glu Val Leu Val Pro Leu Ser 
305                 310                 315                 320 

Glu Met Ser Lys Lys Leu Pro Tyr Tyr Ser Lys Ile Lys Pro Gln Leu 

                325                 330                 335     

Ser Glu Pro Ser Val Val Asp Met Glu Ala Gly Ile Tyr Ser Tyr Thr 
            340                 345                 350         

Val Ala Asp Lys Leu Ile Met Glu Ala Glu Glu Lys Ala Lys Gln Glu 
        355                 360                 365             

Ala Lys Glu Ala Glu Lys Lys Gln Glu Glu Glu Gln Lys Lys Gln Glu 
    370                 375                 380                 

Glu Glu Ser Asn Arg Asn Gln Thr Thr Gln Arg Ser Ser Arg Arg 
385                 390                 395                 

<210>   1291
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1291
ttgatgaaga aggtaacaca tatgtcagat gaagtattct tatttgaaga aattgaagaa   60
atcgtagccc ctacagatgg tgaatttttg ggggaagttt tacttggaac tggggtagtt   120
ctcttaattg gagtagcctg ttgt                                          144

<210>   1292
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   1292
Met Met Lys Lys Val Thr His Met Ser Asp Glu Val Phe Leu Phe Glu 
1               5                   10                  15      

Glu Ile Glu Glu Ile Val Ala Pro Thr Asp Gly Glu Phe Leu Gly Glu 
            20                  25                  30          

Val Leu Leu Gly Thr Gly Val Val Leu Leu Ile Gly Val Ala Cys Cys 
        35                  40                  45              


<210>   1293
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1293
gtgataatca tgcaagataa ctttttattt gaggaaattg aagaaatttc agtaccagtt   60
aatgattttt cagctggact tgcaacaggt atcggatttg gtttagcaat ccttgctctt   120
gctggttgt                                                           129

<210>   1294
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   1294
Met Ile Ile Met Gln Asp Asn Phe Leu Phe Glu Glu Ile Glu Glu Ile 
1               5                   10                  15      

Ser Val Pro Val Asn Asp Phe Ser Ala Gly Leu Ala Thr Gly Ile Gly 
            20                  25                  30          

Phe Gly Leu Ala Ile Leu Ala Leu Ala Gly Cys 
        35                  40              

<210>   1295
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1295
atgagaattg ttgataagat taagatatta cctactcctt atgagggaca ctatcattta   60
tatataccat ccagtaagaa acatgtatta gttgggaaac aggaaaaaaa tggt         114

<210>   1296
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1296
Met Arg Ile Val Asp Lys Ile Lys Ile Leu Pro Thr Pro Tyr Glu Gly 
1               5                   10                  15      

His Tyr His Leu Tyr Ile Pro Ser Ser Lys Lys His Val Leu Val Gly 
            20                  25                  30          

Lys Gln Glu Lys Asn Gly 
        35              

<210>   1297
<211>   561
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1297
ttgaaaaaat cctatcttgt tgtcattata tttgcaacga tacatgaaat tagtcatgca   60
ataattgcta ataattatca aattgagatc ccaaattgtg gaataatgct acttttgttt   120
aatttggctt tttttgtaga tttaagtggg gtgcaattcc taaaaaataa aaaacaattt   180
ttgaaaatta tgttagcagg aattgcttca aattcgattt tatcacttac aggtttactt   240
gttttattgt tcacatcgta taaattgctt ggactcttat tttttatcat taacttaggt   300
atgattttta ttaattcaat tccttttttt cagtatgata gtggtattat tttaagatac   360
ttgaattcta acaataataa cttgaatttt caatatatag ttcaactttt aatagcattt   420
gttattattt attttccttt gagtcaacta ttacagtttt tgacacccaa tattattgtt   480
cgtagtatag gaggggtggt tgtttctata ctgctttcta tattatatat gataggaagg   540
acgaaatatg ttctacgtaa a                                             561

<210>   1298
<211>   187
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902651 (2.E-96)

<400>   1298
Met Lys Lys Ser Tyr Leu Val Val Ile Ile Phe Ala Thr Ile His Glu 
1               5                   10                  15      

Ile Ser His Ala Ile Ile Ala Asn Asn Tyr Gln Ile Glu Ile Pro Asn 
            20                  25                  30          

Cys Gly Ile Met Leu Leu Leu Phe Asn Leu Ala Phe Phe Val Asp Leu 
        35                  40                  45              

Ser Gly Val Gln Phe Leu Lys Asn Lys Lys Gln Phe Leu Lys Ile Met 
    50                  55                  60                  

Leu Ala Gly Ile Ala Ser Asn Ser Ile Leu Ser Leu Thr Gly Leu Leu 
65                  70                  75                  80  

Val Leu Leu Phe Thr Ser Tyr Lys Leu Leu Gly Leu Leu Phe Phe Ile 
                85                  90                  95      

Ile Asn Leu Gly Met Ile Phe Ile Asn Ser Ile Pro Phe Phe Gln Tyr 
            100                 105                 110         

Asp Ser Gly Ile Ile Leu Arg Tyr Leu Asn Ser Asn Asn Asn Asn Leu 
        115                 120                 125             

Asn Phe Gln Tyr Ile Val Gln Leu Leu Ile Ala Phe Val Ile Ile Tyr 
    130                 135                 140                 

Phe Pro Leu Ser Gln Leu Leu Gln Phe Leu Thr Pro Asn Ile Ile Val 
145                 150                 155                 160 

Arg Ser Ile Gly Gly Val Val Val Ser Ile Leu Leu Ser Ile Leu Tyr 
                165                 170                 175     

Met Ile Gly Arg Thr Lys Tyr Val Leu Arg Lys 
            180                 185         

<210>   1299
<211>   633
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1299
atgtatggag tgaggaaact tattgtcgct gattacgata taatagaacc atcaaattta   60
aataggcaaa ttctttatac agagtcggat gttggtaagg agaagattaa tgttctttct   120
gaaaaaatac acaagtataa ttcagatgtt caggtagtac ctatttctat taaagtttct   180
tcagtagaag aattagaaaa aattgttgcg gaatatggga gtatagattt tatcgttaaa   240
gcaattgata cgcccattga tattataaaa attgtcaatc aatttgctgt atcgcataag   300
atatcctaca tatcaggagg gtttaatgga tgctatctta ttattgataa tatatatatc   360
cctaccatcg gttcttgctt tggttgtcgg aatataaaca aagatataaa taagtacact   420
ttatctgata agacaaagtg gccgactaca ccagagatgc ctgctatttt gggagggata   480
atgactaatt taataattaa aatatttctg ggatgttata atgaaatcct aatagataac   540
gcttacgttt ataatatgag aaatcatgct ctaagtcaag aaaaatatgt tctggaaaac   600
ggagaatgtc caatttgtaa aaaaataata aag                                633

<210>   1300
<211>   211
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   HesA/MoeB/ThiF family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902652 (e-119)

<400>   1300
Met Tyr Gly Val Arg Lys Leu Ile Val Ala Asp Tyr Asp Ile Ile Glu 
1               5                   10                  15      

Pro Ser Asn Leu Asn Arg Gln Ile Leu Tyr Thr Glu Ser Asp Val Gly 
            20                  25                  30          

Lys Glu Lys Ile Asn Val Leu Ser Glu Lys Ile His Lys Tyr Asn Ser 
        35                  40                  45              

Asp Val Gln Val Val Pro Ile Ser Ile Lys Val Ser Ser Val Glu Glu 
    50                  55                  60                  

Leu Glu Lys Ile Val Ala Glu Tyr Gly Ser Ile Asp Phe Ile Val Lys 
65                  70                  75                  80  

Ala Ile Asp Thr Pro Ile Asp Ile Ile Lys Ile Val Asn Gln Phe Ala 
                85                  90                  95      

Val Ser His Lys Ile Ser Tyr Ile Ser Gly Gly Phe Asn Gly Cys Tyr 
            100                 105                 110         

Leu Ile Ile Asp Asn Ile Tyr Ile Pro Thr Ile Gly Ser Cys Phe Gly 
        115                 120                 125             

Cys Arg Asn Ile Asn Lys Asp Ile Asn Lys Tyr Thr Leu Ser Asp Lys 
    130                 135                 140                 

Thr Lys Trp Pro Thr Thr Pro Glu Met Pro Ala Ile Leu Gly Gly Ile 
145                 150                 155                 160 

Met Thr Asn Leu Ile Ile Lys Ile Phe Leu Gly Cys Tyr Asn Glu Ile 
                165                 170                 175     

Leu Ile Asp Asn Ala Tyr Val Tyr Asn Met Arg Asn His Ala Leu Ser 
            180                 185                 190         

Gln Glu Lys Tyr Val Leu Glu Asn Gly Glu Cys Pro Ile Cys Lys Lys 
        195                 200                 205             

Ile Ile Lys 
    210     

<210>   1301
<211>   378
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1301
gtgaaagata acaatattag agcgaaaaca tttattcgtt cagtttgttt ttgcttatta   60
tcaggaggag tagctttttt atctgctatt gggcagttca ctgttataga aacacaatta   120
atagtattgt tcttgggtat tatttttgct atatattatg cttactacaa taaaaatatt   180
caaacatcat tggaaaatat agtatggctt ttttcatcgt ttgagatttt atttttgctt   240
gttaatttta gaacatttat tcagttacca gtggatattt ttattggtat gataatattt   300
ttaatgctgt ggatatttat tatgttaggt atagtgtgtc ttagttatta tataacttta   360
ttatttagca aggaggct                                                 378

<210>   1302
<211>   126
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902652 (2.E-65)

<400>   1302
Met Lys Asp Asn Asn Ile Arg Ala Lys Thr Phe Ile Arg Ser Val Cys 
1               5                   10                  15      

Phe Cys Leu Leu Ser Gly Gly Val Ala Phe Leu Ser Ala Ile Gly Gln 
            20                  25                  30          

Phe Thr Val Ile Glu Thr Gln Leu Ile Val Leu Phe Leu Gly Ile Ile 
        35                  40                  45              

Phe Ala Ile Tyr Tyr Ala Tyr Tyr Asn Lys Asn Ile Gln Thr Ser Leu 
    50                  55                  60                  

Glu Asn Ile Val Trp Leu Phe Ser Ser Phe Glu Ile Leu Phe Leu Leu 
65                  70                  75                  80  

Val Asn Phe Arg Thr Phe Ile Gln Leu Pro Val Asp Ile Phe Ile Gly 
                85                  90                  95      

Met Ile Ile Phe Leu Met Leu Trp Ile Phe Ile Met Leu Gly Ile Val 
            100                 105                 110         

Cys Leu Ser Tyr Tyr Ile Thr Leu Leu Phe Ser Lys Glu Ala 
        115                 120                 125     

<210>   1303
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1303
atgttaagta aaaatgtaga atataaagga ggtgcaatga gtatgattga agttagccat   60
ttatcaaaaa gttttggtga taaaatagct ttaaataata taagcttcac tgttaaagaa   120
ggttagattt ttggattttt agaaccatct ggttctggaa agaccacaac gattaatatt   180
ctgactgggc agttccttgc cgataaagga caatctatta ttttgggaca aaaatctcaa   240
aatttaacaa gcggtgaatt aaagagaatt ggattggtta gcgatacaag tggattttat   300
gagaaaatgt ctctgtataa caatcttctt ttttatagta aattttataa tattagtaaa   360
tcacgtgttg ataatttgtt aaagcgagta ggattatatg atagtcgcaa gatggtagca   420
ggaaaattat ccactggaat gaggcaacga atgcttttag cacgagctct tatcaacaac   480
cccgctgtac tctttctgga tgaaccgacc tcaggtctag atcccacaac ttctcgaaca   540
attcatgagt taattttaga attgaaaaca gcagggacaa cgatttttct aacgactcat   600
gatatgaatg aagcaactct tttatgtgat tatgttgcct tattaaataa agggaaatta   660
gttgagcaag gagctccttc tgaactcatt caaagatata ataaagataa aaagattaag   720
gttacagatt ataatgggaa tcagataact tttgatttta catcactaga acaggtatct   780
cagactgatc tggaaaatat tttttcaatt cattcatgtg agcctacttt agaagatatt   840
tttatcacat taacaggagg aaagctaaat gct                                873


<210>   1304
<400>   1304
000

<210>   1305
<211>   711
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1305
atgcttaaac ggtttctggc tttggtatgg ttgcgttgtc aaatcatcct ttccaataag   60
agtattttat tgcaagtttt agtgcctttt gctttcacat atttttataa atatcttatg   120
gaaacacagg ggaaggtcaa cgatcaacag gcattagttc ttttgatgat gtgtttacct   180
ttttcttttt ctttggctgt tggaagtcct ataactatta tcttgtctga agaaaaagaa   240
aagtacaatt tacaaactct tctgttgagt ggtgttaaag gctccgaata cattttatca   300
actatgtttc ttcctttttt gctaactttt gtgattatgg gaactactcc tcttatttta   360
ggagttacaa ttgtacatac ttttaattat attacaatcg ttcttctaac ctctttatcc   420
atcattttat tctatttatt gataggttta accgcgaaga gccaagtagt agctcaggtt   480
atcagtcttc ctgctatgat tttagttgct ttcttaccga tgctatctgg tttggataag   540
acagttgcga agataacaga ttatagtttt atgggactat ttactaagtt tttcacaaaa   600
tgggaggaat tttcatggaa taaaactcta attcctaatc taacactact tatttggatt   660
gttcttctat taactttaat tacgataact attaggaaaa agaaaatttc t            711

<210>   1306
<211>   237
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902655 (e-127)

<400>   1306
Met Leu Lys Arg Phe Leu Ala Leu Val Trp Leu Arg Cys Gln Ile Ile 
1               5                   10                  15      

Leu Ser Asn Lys Ser Ile Leu Leu Gln Val Leu Val Pro Phe Ala Phe 
            20                  25                  30          

Thr Tyr Phe Tyr Lys Tyr Leu Met Glu Thr Gln Gly Lys Val Asn Asp 
        35                  40                  45              

Gln Gln Ala Leu Val Leu Leu Met Met Cys Leu Pro Phe Ser Phe Ser 
    50                  55                  60                  

Leu Ala Val Gly Ser Pro Ile Thr Ile Ile Leu Ser Glu Glu Lys Glu 
65                  70                  75                  80  

Lys Tyr Asn Leu Gln Thr Leu Leu Leu Ser Gly Val Lys Gly Ser Glu 
                85                  90                  95      

Tyr Ile Leu Ser Thr Met Phe Leu Pro Phe Leu Leu Thr Phe Val Ile 
            100                 105                 110         

Met Gly Thr Thr Pro Leu Ile Leu Gly Val Thr Ile Val His Thr Phe 
        115                 120                 125             

Asn Tyr Ile Thr Ile Val Leu Leu Thr Ser Leu Ser Ile Ile Leu Phe 
    130                 135                 140                 

Tyr Leu Leu Ile Gly Leu Thr Ala Lys Ser Gln Val Val Ala Gln Val 
145                 150                 155                 160 

Ile Ser Leu Pro Ala Met Ile Leu Val Ala Phe Leu Pro Met Leu Ser 
                165                 170                 175     

Gly Leu Asp Lys Thr Val Ala Lys Ile Thr Asp Tyr Ser Phe Met Gly 
            180                 185                 190         

Leu Phe Thr Lys Phe Phe Thr Lys Trp Glu Glu Phe Ser Trp Asn Lys 
        195                 200                 205             

Thr Leu Ile Pro Asn Leu Thr Leu Leu Ile Trp Ile Val Leu Leu Leu 
    210                 215                 220                 

Thr Leu Ile Thr Ile Thr Ile Arg Lys Lys Lys Ile Ser 
225                 230                 235         

<210>   1307
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1307
ttgagttatt ttaatgatta taaacacaag tgggaaggaa aaaatgaact gatctttttg   60
acagcaattc tacagaatag tcttattgct atattt                             96

<210>   1308
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   1308
Met Ser Tyr Phe Asn Asp Tyr Lys His Lys Trp Glu Gly Lys Asn Glu 
1               5                   10                  15      

Leu Ile Phe Leu Thr Ala Ile Leu Gln Asn Ser Leu Ile Ala Ile Phe 
            20                  25                  30          


<210>   1309
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1309
atgggaattc tgttttattt tgcggatgcc tattcatctt ggcaaagggg aagtaatgag   60
aatgcgaatg gacttcttcg tgagtatttt cttaaaccga tttggcaaca attaccgaaa   120
aaatccttaa tgatgctttg c                                             141

<210>   1310
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, IS30 family, truncation POINT MUTATION

<400>   1310
Met Gly Ile Leu Phe Tyr Phe Ala Asp Ala Tyr Ser Ser Trp Gln Arg 
1               5                   10                  15      

Gly Ser Asn Glu Asn Ala Asn Gly Leu Leu Arg Glu Tyr Phe Leu Lys 
            20                  25                  30          

Pro Ile Trp Gln Gln Leu Pro Lys Lys Ser Leu Met Met Leu Cys 
        35                  40                  45          

<210>   1311
<211>   699
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1311
atgcgagaac atcgtccaat cattgctctt gattttccta gttttgaggc ggtcaaggaa   60
tttttagctc ttttcccagc agaagaaagc ctttatctca aggtagggat ggagctttat   120
tacgcagcgg ggcctgagat tgtgtcctac ttaaaaggtt tgggtcatag tgtctttttg   180
gatctcaaac ttcatgacat tcctaataca gtcaagtcag ccatgaagat cttgtctcag   240
cttggtgtcg atatgactaa tgtccatgcg gctggtggtg tagagatgat gaaggcggcg   300
cgtgaaggtc ttgggagtca agccaaattg atcgctgtaa ctcagctcac atcaacgtca   360
gaagctcaga tgcaggagtt tcaaaatatc caaaccagtc tgcaagagtc tgtgattcac   420
tatgccaaga agacagctga agctggcttg gatggtgttg tttgctcggc tcaggaagta   480
caagtcatca agcaggctac caatccagat tttatctgtc tgacaccagg gattcgtcca   540
gctggtgttg cagttggaga tcaaaaacga gtcatgacac ctgctgatgc ctatcaaatc   600
ggcagtgact atatcgtagt gggacgtccc attacccaag ctgaggatcc tgttgcagct   660
tatcatgcca tcaaggatga atggacacag gactggaat                          699

<210>   1312
<211>   233
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   orotidine 5'-phosphate decarboxylase (pyrF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902657 (e-131)

<400>   1312
Met Arg Glu His Arg Pro Ile Ile Ala Leu Asp Phe Pro Ser Phe Glu 
1               5                   10                  15      

Ala Val Lys Glu Phe Leu Ala Leu Phe Pro Ala Glu Glu Ser Leu Tyr 
            20                  25                  30          

Leu Lys Val Gly Met Glu Leu Tyr Tyr Ala Ala Gly Pro Glu Ile Val 
        35                  40                  45              

Ser Tyr Leu Lys Gly Leu Gly His Ser Val Phe Leu Asp Leu Lys Leu 
    50                  55                  60                  

His Asp Ile Pro Asn Thr Val Lys Ser Ala Met Lys Ile Leu Ser Gln 
65                  70                  75                  80  

Leu Gly Val Asp Met Thr Asn Val His Ala Ala Gly Gly Val Glu Met 
                85                  90                  95      

Met Lys Ala Ala Arg Glu Gly Leu Gly Ser Gln Ala Lys Leu Ile Ala 
            100                 105                 110         

Val Thr Gln Leu Thr Ser Thr Ser Glu Ala Gln Met Gln Glu Phe Gln 
        115                 120                 125             

Asn Ile Gln Thr Ser Leu Gln Glu Ser Val Ile His Tyr Ala Lys Lys 
    130                 135                 140                 

Thr Ala Glu Ala Gly Leu Asp Gly Val Val Cys Ser Ala Gln Glu Val 
145                 150                 155                 160 

Gln Val Ile Lys Gln Ala Thr Asn Pro Asp Phe Ile Cys Leu Thr Pro 

                165                 170                 175     

Gly Ile Arg Pro Ala Gly Val Ala Val Gly Asp Gln Lys Arg Val Met 
            180                 185                 190         

Thr Pro Ala Asp Ala Tyr Gln Ile Gly Ser Asp Tyr Ile Val Val Gly 
        195                 200                 205             

Arg Pro Ile Thr Gln Ala Glu Asp Pro Val Ala Ala Tyr His Ala Ile 
    210                 215                 220                 

Lys Asp Glu Trp Thr Gln Asp Trp Asn 
225                 230             

<210>   1313
<211>   630
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1313
atgacacttg ctaaagatat cgctagccac ctcttgaaaa tccaagccgt ttacctcaaa   60
ccagaggaac ccttcacttg ggcatctggt atcaagtcac cgatttacac tgataatcgt   120
gtgacactag cctatccaga aactcgtacc ctaattgaaa atggttttgt ggaagctatc   180
aaagaagcct ttcctgaagt agaagtgatt gcaggaactg caacagcagg gattccacac   240
ggagccatta ttgctgataa gatggacttg ccttttgcct acatccgtag taaaccaaaa   300
gaccacggag ctggtaatca aatcgaaggt cgcgtagctc aaggtcaaaa aatggtagtg   360
gttgaagacc ttatttcaac gggtggttca gttcttgaag ctgtagcagc agccaagcga   420
gaaggagcag atgtacttgg agttgtagcg attttcagct accaattgcc aaaagcagat   480
aagaactttg cagatgctgg tgttaaactt gtgacgcttt caaactatag cgagcttatc   540
catctagccc aagaagaagg ttacatcacg ccagagggcc ttgatcttct aaaacgcttt   600
aaagaagacc aagaaaattg gcaagaaggt                                    630

<210>   1314
<211>   210
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   orotate phosphoribosyltransferase PyrE (pyrE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902658 (e-116)

<400>   1314
Met Thr Leu Ala Lys Asp Ile Ala Ser His Leu Leu Lys Ile Gln Ala 
1               5                   10                  15      

Val Tyr Leu Lys Pro Glu Glu Pro Phe Thr Trp Ala Ser Gly Ile Lys 
            20                  25                  30          

Ser Pro Ile Tyr Thr Asp Asn Arg Val Thr Leu Ala Tyr Pro Glu Thr 
        35                  40                  45              

Arg Thr Leu Ile Glu Asn Gly Phe Val Glu Ala Ile Lys Glu Ala Phe 
    50                  55                  60                  

Pro Glu Val Glu Val Ile Ala Gly Thr Ala Thr Ala Gly Ile Pro His 
65                  70                  75                  80  

Gly Ala Ile Ile Ala Asp Lys Met Asp Leu Pro Phe Ala Tyr Ile Arg 
                85                  90                  95      

Ser Lys Pro Lys Asp His Gly Ala Gly Asn Gln Ile Glu Gly Arg Val 
            100                 105                 110         

Ala Gln Gly Gln Lys Met Val Val Val Glu Asp Leu Ile Ser Thr Gly 
        115                 120                 125             

Gly Ser Val Leu Glu Ala Val Ala Ala Ala Lys Arg Glu Gly Ala Asp 
    130                 135                 140                 

Val Leu Gly Val Val Ala Ile Phe Ser Tyr Gln Leu Pro Lys Ala Asp 
145                 150                 155                 160 

Lys Asn Phe Ala Asp Ala Gly Val Lys Leu Val Thr Leu Ser Asn Tyr 
                165                 170                 175     

Ser Glu Leu Ile His Leu Ala Gln Glu Glu Gly Tyr Ile Thr Pro Glu 
            180                 185                 190         

Gly Leu Asp Leu Leu Lys Arg Phe Lys Glu Asp Gln Glu Asn Trp Gln 
        195                 200                 205             

Glu Gly 
    210 

<210>   1315
<211>   348
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1315
ttgtttctcc ctacagtttt agctagacag attggagatt atgatttaac gtcgccgcgt   60
tggggttcgg atacaactag tgagcttgag aaagaaaact cctctgctgg aattaataat   120
aatgacagca ctggtggcgg taaaaggtta aatacctcta ttcgtagcgc ctatagtggg   180
tcagatatta ccccggtata ttcattgggg tctggctcta ggattgtcat gtactataat   240
ggaggtggtg acaattatat tggttctggt actagattag ctatggcgcc acaatttgga   300
aatcatgtaa gaattcatac ttcaggttct tggaatccag attcttat                348

<210>   1316
<211>   116
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902659 (3.E-63)

<400>   1316
Met Phe Leu Pro Thr Val Leu Ala Arg Gln Ile Gly Asp Tyr Asp Leu 
1               5                   10                  15      

Thr Ser Pro Arg Trp Gly Ser Asp Thr Thr Ser Glu Leu Glu Lys Glu 
            20                  25                  30          

Asn Ser Ser Ala Gly Ile Asn Asn Asn Asp Ser Thr Gly Gly Gly Lys 

        35                  40                  45              

Arg Leu Asn Thr Ser Ile Arg Ser Ala Tyr Ser Gly Ser Asp Ile Thr 
    50                  55                  60                  

Pro Val Tyr Ser Leu Gly Ser Gly Ser Arg Ile Val Met Tyr Tyr Asn 
65                  70                  75                  80  

Gly Gly Gly Asp Asn Tyr Ile Gly Ser Gly Thr Arg Leu Ala Met Ala 
                85                  90                  95      

Pro Gln Phe Gly Asn His Val Arg Ile His Thr Ser Gly Ser Trp Asn 
            100                 105                 110         

Pro Asp Ser Tyr 
        115     

<210>   1317
<211>   762
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1317
atggaatttt tcatttgtaa tcttgtacga gtcgttcaat cacctcgatt ttatatgtct   60
ttatttttga cccttctttg catgagttta ggaaatttcc ttgctttcaa tggtatttat   120
aaaattgaag gtttatcgat tttttttgcc gcttcttcta ttcgaggatt ttcaccgatt   180
agcctagtag ctgcacttat ctgtacactg ccctattcta gtcagataat agaggatgct   240
gagagtcatt ttctaacagc acaattgtgt cgaatttcta aaaagaagta tctggctatt   300
gtgggtagta ctgtaattat ttcttctttt ctagtctttt ttctccccta tttattatta   360
ttaggaatta atcttttagt gactccttat caggaaattt atattggaga ttatagtggt   420
gccttaaaag aattatttga ttccaatcag tttctctata gtcttgtaac gactctctgg   480
tatggagttt ggggcgctgt gttctctatt tttggactag ctagtgcttt gctagtgaag   540
aaaaaaatag gagctatttt catcccagtt gcctatatga tggttggtgg tattttttgg   600
gctattttag ggctatctta cttagaacct gtgacaacgc tagctttggg atatcagaaa   660
gatatcagtc tttccttagt tagtgctcat cttgctttta ttttatttgt tagttgtttg   720
gttgtttatg gtacattttt tctacattca gaggactatg ta                      762

<210>   1318
<211>   254
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902660 (e-140)

<400>   1318
Met Glu Phe Phe Ile Cys Asn Leu Val Arg Val Val Gln Ser Pro Arg 
1               5                   10                  15      

Phe Tyr Met Ser Leu Phe Leu Thr Leu Leu Cys Met Ser Leu Gly Asn 
            20                  25                  30          

Phe Leu Ala Phe Asn Gly Ile Tyr Lys Ile Glu Gly Leu Ser Ile Phe 
        35                  40                  45              

Phe Ala Ala Ser Ser Ile Arg Gly Phe Ser Pro Ile Ser Leu Val Ala 
    50                  55                  60                  

Ala Leu Ile Cys Thr Leu Pro Tyr Ser Ser Gln Ile Ile Glu Asp Ala 
65                  70                  75                  80  

Glu Ser His Phe Leu Thr Ala Gln Leu Cys Arg Ile Ser Lys Lys Lys 
                85                  90                  95      

Tyr Leu Ala Ile Val Gly Ser Thr Val Ile Ile Ser Ser Phe Leu Val 
            100                 105                 110         

Phe Phe Leu Pro Tyr Leu Leu Leu Leu Gly Ile Asn Leu Leu Val Thr 
        115                 120                 125             

Pro Tyr Gln Glu Ile Tyr Ile Gly Asp Tyr Ser Gly Ala Leu Lys Glu 
    130                 135                 140                 

Leu Phe Asp Ser Asn Gln Phe Leu Tyr Ser Leu Val Thr Thr Leu Trp 
145                 150                 155                 160 

Tyr Gly Val Trp Gly Ala Val Phe Ser Ile Phe Gly Leu Ala Ser Ala 
                165                 170                 175     

Leu Leu Val Lys Lys Lys Ile Gly Ala Ile Phe Ile Pro Val Ala Tyr 
            180                 185                 190         

Met Met Val Gly Gly Ile Phe Trp Ala Ile Leu Gly Leu Ser Tyr Leu 
        195                 200                 205             

Glu Pro Val Thr Thr Leu Ala Leu Gly Tyr Gln Lys Asp Ile Ser Leu 
    210                 215                 220                 

Ser Leu Val Ser Ala His Leu Ala Phe Ile Leu Phe Val Ser Cys Leu 
225                 230                 235                 240 

Val Val Tyr Gly Thr Phe Phe Leu His Ser Glu Asp Tyr Val 
                245                 250                 

<210>   1319
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1319
ttgtttggtt gtttatggta cattttttct acattcagag gactatgtat aatgaaacaa   60
tttgttcaat tttataaaaa agatttctta gcagtattgg tttattttat attactgcta   120
tcctgtgttt tatctagtac agtatattta ttgcgctgtc gccaatattc aatccatcca   180
aatgtattag aatggatctt agttttactt caagatatga cgactggagt atattgcttt   240
ccgttcacat atatattgtt ctttttttat ttgatgaata actattttaa taggttggag   300
tgtcgcattc gtctgaaatc aattaagcac tttaccagtt ttagtttcaa attagcagct   360
cttagtacgg ggatttggac ggcgacttta tttttattga tttttctaat tgcatttagt   420
aatggtttta gcttctcttt ggagataaag gaggttgatt ttttaagaga attttatggt   480
ataagtattg caaacaatgc tagtttcttt ataggatttt ttttctctta tatagcatac   540
tatttctttt tatccttact tactattagc agtttttctt ggtttaaaaa atcaaacatg   600
agcttagtat ttctgtttac ttttttattt gtagaatcct tattctggat ttatcagttg   660
gacaatggga taattggatt attgccaatt tttcagtata tggtaaattc caatccgtat   720
gcattgattt attggcttac attactatct atcataattc cattgactgt attttctgtt   780
catagaaact ggaggagagt g                                             801

<210>   1320
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902661 (e-156)

<400>   1320
Met Phe Gly Cys Leu Trp Tyr Ile Phe Ser Thr Phe Arg Gly Leu Cys 
1               5                   10                  15      

Ile Met Lys Gln Phe Val Gln Phe Tyr Lys Lys Asp Phe Leu Ala Val 
            20                  25                  30          

Leu Val Tyr Phe Ile Leu Leu Leu Ser Cys Val Leu Ser Ser Thr Val 
        35                  40                  45              

Tyr Leu Leu Arg Cys Arg Gln Tyr Ser Ile His Pro Asn Val Leu Glu 
    50                  55                  60                  

Trp Ile Leu Val Leu Leu Gln Asp Met Thr Thr Gly Val Tyr Cys Phe 
65                  70                  75                  80  

Pro Phe Thr Tyr Ile Leu Phe Phe Phe Tyr Leu Met Asn Asn Tyr Phe 
                85                  90                  95      

Asn Arg Leu Glu Cys Arg Ile Arg Leu Lys Ser Ile Lys His Phe Thr 
            100                 105                 110         

Ser Phe Ser Phe Lys Leu Ala Ala Leu Ser Thr Gly Ile Trp Thr Ala 
        115                 120                 125             

Thr Leu Phe Leu Leu Ile Phe Leu Ile Ala Phe Ser Asn Gly Phe Ser 
    130                 135                 140                 

Phe Ser Leu Glu Ile Lys Glu Val Asp Phe Leu Arg Glu Phe Tyr Gly 
145                 150                 155                 160 

Ile Ser Ile Ala Asn Asn Ala Ser Phe Phe Ile Gly Phe Phe Phe Ser 
                165                 170                 175     

Tyr Ile Ala Tyr Tyr Phe Phe Leu Ser Leu Leu Thr Ile Ser Ser Phe 
            180                 185                 190         

Ser Trp Phe Lys Lys Ser Asn Met Ser Leu Val Phe Leu Phe Thr Phe 
        195                 200                 205             

Leu Phe Val Glu Ser Leu Phe Trp Ile Tyr Gln Leu Asp Asn Gly Ile 
    210                 215                 220                 

Ile Gly Leu Leu Pro Ile Phe Gln Tyr Met Val Asn Ser Asn Pro Tyr 
225                 230                 235                 240 

Ala Leu Ile Tyr Trp Leu Thr Leu Leu Ser Ile Ile Ile Pro Leu Thr 
                245                 250                 255     

Val Phe Ser Val His Arg Asn Trp Arg Arg Val 
            260                 265         

<210>   1321
<211>   702
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1321
ttggaaatgg gaaagttaag tagtcacatg tggaggttga atcagataat ctataccaag   60
tacttttggg gttatgttct tttttggata ttgatttgtt taggattatg gtattggtta   120
gaaggaaatg atagacttgt tatagaaatt ttaaaagggc ctaatctgag tcaaaactct   180
tttttagtct tatctatatg gttgcttcat tggtttatta ttcatacatt ttttctagca   240
gttgtatatc gtagaagagc atccgatttc tttatggaag tgattcgatt ttcttctatt   300
aagctctgga ttaggtatca gatttggacc tgttttcttt atggactcat tttaatcatg   360
gtaaaagttc tagtgattca atttatgtta cagttaccaa actgggatat aggagttttg   420
tttatagttg attctttgaa tgcttgtgtg ttagtcttgt tttgctttat gttatacgca   480
ctaggagcga atgtacaaat gaactttgct tgcgttagtt tctttttact catgattgtg   540
tttggtggtc tatttgtagg aaatcgaact aattatctat tttatatttt gaatcgaggg   600
aatggagata taggacgaga tttatttctt cagttgctat ttttagtctt tctttttcaa   660
agcattttct atttcactcg tcaaaagagg aggtttatag aa                      702

<210>   1322
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902662 (e-138)

<400>   1322
Met Glu Met Gly Lys Leu Ser Ser His Met Trp Arg Leu Asn Gln Ile 
1               5                   10                  15      

Ile Tyr Thr Lys Tyr Phe Trp Gly Tyr Val Leu Phe Trp Ile Leu Ile 
            20                  25                  30          

Cys Leu Gly Leu Trp Tyr Trp Leu Glu Gly Asn Asp Arg Leu Val Ile 
        35                  40                  45              

Glu Ile Leu Lys Gly Pro Asn Leu Ser Gln Asn Ser Phe Leu Val Leu 
    50                  55                  60                  

Ser Ile Trp Leu Leu His Trp Phe Ile Ile His Thr Phe Phe Leu Ala 
65                  70                  75                  80  

Val Val Tyr Arg Arg Arg Ala Ser Asp Phe Phe Met Glu Val Ile Arg 
                85                  90                  95      

Phe Ser Ser Ile Lys Leu Trp Ile Arg Tyr Gln Ile Trp Thr Cys Phe 
            100                 105                 110         

Leu Tyr Gly Leu Ile Leu Ile Met Val Lys Val Leu Val Ile Gln Phe 
        115                 120                 125             

Met Leu Gln Leu Pro Asn Trp Asp Ile Gly Val Leu Phe Ile Val Asp 
    130                 135                 140                 

Ser Leu Asn Ala Cys Val Leu Val Leu Phe Cys Phe Met Leu Tyr Ala 
145                 150                 155                 160 

Leu Gly Ala Asn Val Gln Met Asn Phe Ala Cys Val Ser Phe Phe Leu 
                165                 170                 175     

Leu Met Ile Val Phe Gly Gly Leu Phe Val Gly Asn Arg Thr Asn Tyr 
            180                 185                 190         

Leu Phe Tyr Ile Leu Asn Arg Gly Asn Gly Asp Ile Gly Arg Asp Leu 
        195                 200                 205             

Phe Leu Gln Leu Leu Phe Leu Val Phe Leu Phe Gln Ser Ile Phe Tyr 
    210                 215                 220                 

Phe Thr Arg Gln Lys Arg Arg Phe Ile Glu 
225                 230                 

<210>   1323
<211>   645
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1323
atgaatgaaa taattacatt aaaaaatatt gagttgaaat taaaaaagac atgtgttttt   60
caaaacctta actttagttg taaacagggg gaaattatag gaattactgg tgcgaatggc   120
tcagggaaaa gtgtattgtt taaattaata gctggtttat atagtccgtc ttatggagaa   180
gtgttaatca atggggaaaa tattgttcct gagagaaaaa ttccagctaa tttgggagct   240
ttgattgaag aacctggttt tataaattat tatagtggct ttaagaattt acaatatttg   300
gcaagcatac gaggagtagt tggtaatcag gaaatcaatg atacactgaa aatagttggt   360
ctatatgagc aaaaagacca gaaagttaaa acttattcgc taggtatgag gaaaaagcta   420
gggattgctc aagcaattat ggagaatccc tctattcttt tactagatga acctatgaat   480
gccttggata aatcaagtgt agaaaatatg agaacattgt ttagaaagct ctctagtgaa   540
aaagggacaa caattttgat tgctagtcat agtgaagagg atattcgtat cttatgtgat   600
aaagtatatg caatagaaga taaagtatgt acactgtgtt cagat                   645

<210>   1324
<211>   215
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902663 (e-119)

<400>   1324
Met Asn Glu Ile Ile Thr Leu Lys Asn Ile Glu Leu Lys Leu Lys Lys 
1               5                   10                  15      

Thr Cys Val Phe Gln Asn Leu Asn Phe Ser Cys Lys Gln Gly Glu Ile 
            20                  25                  30          

Ile Gly Ile Thr Gly Ala Asn Gly Ser Gly Lys Ser Val Leu Phe Lys 
        35                  40                  45              

Leu Ile Ala Gly Leu Tyr Ser Pro Ser Tyr Gly Glu Val Leu Ile Asn 
    50                  55                  60                  

Gly Glu Asn Ile Val Pro Glu Arg Lys Ile Pro Ala Asn Leu Gly Ala 
65                  70                  75                  80  

Leu Ile Glu Glu Pro Gly Phe Ile Asn Tyr Tyr Ser Gly Phe Lys Asn 
                85                  90                  95      

Leu Gln Tyr Leu Ala Ser Ile Arg Gly Val Val Gly Asn Gln Glu Ile 
            100                 105                 110         

Asn Asp Thr Leu Lys Ile Val Gly Leu Tyr Glu Gln Lys Asp Gln Lys 
        115                 120                 125             

Val Lys Thr Tyr Ser Leu Gly Met Arg Lys Lys Leu Gly Ile Ala Gln 
    130                 135                 140                 

Ala Ile Met Glu Asn Pro Ser Ile Leu Leu Leu Asp Glu Pro Met Asn 
145                 150                 155                 160 

Ala Leu Asp Lys Ser Ser Val Glu Asn Met Arg Thr Leu Phe Arg Lys 
                165                 170                 175     

Leu Ser Ser Glu Lys Gly Thr Thr Ile Leu Ile Ala Ser His Ser Glu 

            180                 185                 190         

Glu Asp Ile Arg Ile Leu Cys Asp Lys Val Tyr Ala Ile Glu Asp Lys 
        195                 200                 205             

Val Cys Thr Leu Cys Ser Asp 
    210                 215 

<210>   1325
<211>   869
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1325
atgaaactat tcaaaccact cttaactgtt ttagcacttg cctttgccct tatctttatc   60
actgcttgta gctcaggtgg aaacgctggt tcatcctctg gaaaaacaac tgccaaagct   120
cgcactatcg atgaaatcaa aaaaagcggt gaactgcgaa tcgccgtgtt tggagataaa   180
aaaccgtttg gctacgttga caatgatggt tcttaccaag gctacgctac gatattgaac   240
tagggaacca actagctcaa gaccttggtg tcaaggttaa atacatttca gtcgatgctg   300
ccaaccgtgc ggaatacttg atttcaaaca aggtagatat tactcttgct aactttacag   360
taactgacga acgtaagaaa caagttgatt ttgcccttcc atatatgaaa gtttctctgg   420
gtgtcgtatc acctaagact ggtctcatta cagacgtcaa acaacttgaa ggtaaaacct   480
taattgtcac aaaaggaacg actgctgaga cttattttga aaagaatcat ccagaaatca   540
aactccaaaa atacgaccaa tacagtgact cttaccaagc tcttcttgac ggacgtggag   600
atgccttttc aactgacaat acggaagttc tagcttgggc gcttgaaaat aaaggatttg   660
aagtaggaat tacttccctc ggtgatcccg ataccattgc ggcagcagtt caaaaaggca   720
accaagaatt gctagacttc atcaataaag atattgaaaa attaggcaag gaaaacttct   780
tccacaaggc ctatgaaaag acacttcacc caacctacgg tgacgctgct aaagcagatg   840
acctggttgt tgaaggtgga aaagttgat                                     869

<210>   1326
<211>   184
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, amino acid-binding protein FRAMESHIFT

<400>   1326
Met Ile Ser Asn Lys Val Asp Ile Thr Leu Ala Asn Phe Thr Val Thr 
1               5                   10                  15      

Asp Glu Arg Lys Lys Gln Val Asp Phe Ala Leu Pro Tyr Met Lys Val 
            20                  25                  30          

Ser Leu Gly Val Val Ser Pro Lys Thr Gly Leu Ile Thr Asp Val Lys 
        35                  40                  45              

Gln Leu Glu Gly Lys Thr Leu Ile Val Thr Lys Gly Thr Thr Ala Glu 
    50                  55                  60                  

Thr Tyr Phe Glu Lys Asn His Pro Glu Ile Lys Leu Gln Lys Tyr Asp 
65                  70                  75                  80  

Gln Tyr Ser Asp Ser Tyr Gln Ala Leu Leu Asp Gly Arg Gly Asp Ala 
                85                  90                  95      

Phe Ser Thr Asp Asn Thr Glu Val Leu Ala Trp Ala Leu Glu Asn Lys 
            100                 105                 110         


Gly Phe Glu Val Gly Ile Thr Ser Leu Gly Asp Pro Asp Thr Ile Ala 
        115                 120                 125             

Ala Ala Val Gln Lys Gly Asn Gln Glu Leu Leu Asp Phe Ile Asn Lys 
    130                 135                 140                 

Asp Ile Glu Lys Leu Gly Lys Glu Asn Phe Phe His Lys Ala Tyr Glu 
145                 150                 155                 160 

Lys Thr Leu His Pro Thr Tyr Gly Asp Ala Ala Lys Ala Asp Asp Leu 
                165                 170                 175     

Val Val Glu Gly Gly Lys Val Asp 
            180                 

<210>   1327
<211>   240
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1327
atgaaactat tcaaaccact cttaactgtt ttagcacttg cctttgccct tatctttatc   60
actgcttgta gctcaggtgg aaacgctggt tcatcctctg gaaaaacaac tgccaaagct   120
cgcactatcg atgaaatcaa aaaaagcggt gaactgcgaa tcgccgtgtt tggagataaa   180
aaaccgtttg gctacgttga caatgatggt tcttaccaag gctacgctac gatattgaac   240

<210>   1328
<211>   80
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   outer membrane protein, FRAMESHIFT

<400>   1328
Met Lys Leu Phe Lys Pro Leu Leu Thr Val Leu Ala Leu Ala Phe Ala 
1               5                   10                  15      

Leu Ile Phe Ile Thr Ala Cys Ser Ser Gly Gly Asn Ala Gly Ser Ser 
            20                  25                  30          

Ser Gly Lys Thr Thr Ala Lys Ala Arg Thr Ile Asp Glu Ile Lys Lys 
        35                  40                  45              

Ser Gly Glu Leu Arg Ile Ala Val Phe Gly Asp Lys Lys Pro Phe Gly 
    50                  55                  60                  

Tyr Val Asp Asn Asp Gly Ser Tyr Gln Gly Tyr Ala Thr Ile Leu Asn 
65                  70                  75                  80  


<210>   1329
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1329
atgtctgaaa ctatcttaga aatcaaggaa ctaaaaaaat ccttcggaga caatcccatc   60
ctccaaggac tttctctaga aatcaaaaaa ggggaagttg ttgtcatcct agggccatct   120
ggttgtggga aaagtaccct ccttcgttgc ctcaacggct tagaaagtat tcaaggtgga   180
gatattcttc tggatggtca gtctatcgtt gaaaataaaa aagattttca cctagttcgc   240
caaaagattg gcatggtctt tcaaagttat gaactctttc cccatctgga tgtcttacaa   300
aacctcatcc taggccctat caaagctcaa ggaagggaca agaaagaagt aacggaagaa   360
gctttgcaat tactagagcg tgtcggtttg ctggataaac aacatagctt tgcccgtcaa   420
ttatctggtg gacagaagca acgtgttgca attgtccgtg ccctcctaat gcatccagaa   480
atcatccttt ttgacgaggt gactgcttcg ctggatccag aaatggtgcg tgaggtgctg   540
gaacttatca atgatttggc ccaagaaggc cgtaccatga ttttagtaac ccacgaaatg   600
cagtttgccc aagccattac tgaccggatt atcttcctcg accaagggaa aatcgctgaa   660
gaaggaacag ctcaagcctt ctttaccaat ccgcaaacca aacgagccca ggaattttta   720
aacgtctttg actttagcca attcggctca tatcta                             756

<210>   1330
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902666 (e-139)

<400>   1330
Met Ser Glu Thr Ile Leu Glu Ile Lys Glu Leu Lys Lys Ser Phe Gly 
1               5                   10                  15      

Asp Asn Pro Ile Leu Gln Gly Leu Ser Leu Glu Ile Lys Lys Gly Glu 
            20                  25                  30          

Val Val Val Ile Leu Gly Pro Ser Gly Cys Gly Lys Ser Thr Leu Leu 
        35                  40                  45              

Arg Cys Leu Asn Gly Leu Glu Ser Ile Gln Gly Gly Asp Ile Leu Leu 
    50                  55                  60                  

Asp Gly Gln Ser Ile Val Glu Asn Lys Lys Asp Phe His Leu Val Arg 
65                  70                  75                  80  

Gln Lys Ile Gly Met Val Phe Gln Ser Tyr Glu Leu Phe Pro His Leu 
                85                  90                  95      

Asp Val Leu Gln Asn Leu Ile Leu Gly Pro Ile Lys Ala Gln Gly Arg 
            100                 105                 110         

Asp Lys Lys Glu Val Thr Glu Glu Ala Leu Gln Leu Leu Glu Arg Val 
        115                 120                 125             

Gly Leu Leu Asp Lys Gln His Ser Phe Ala Arg Gln Leu Ser Gly Gly 
    130                 135                 140                 

Gln Lys Gln Arg Val Ala Ile Val Arg Ala Leu Leu Met His Pro Glu 
145                 150                 155                 160 

Ile Ile Leu Phe Asp Glu Val Thr Ala Ser Leu Asp Pro Glu Met Val 
                165                 170                 175     

Arg Glu Val Leu Glu Leu Ile Asn Asp Leu Ala Gln Glu Gly Arg Thr 
            180                 185                 190         

Met Ile Leu Val Thr His Glu Met Gln Phe Ala Gln Ala Ile Thr Asp 
        195                 200                 205             

Arg Ile Ile Phe Leu Asp Gln Gly Lys Ile Ala Glu Glu Gly Thr Ala 
    210                 215                 220                 

Gln Ala Phe Phe Thr Asn Pro Gln Thr Lys Arg Ala Gln Glu Phe Leu 
225                 230                 235                 240 

Asn Val Phe Asp Phe Ser Gln Phe Gly Ser Tyr Leu 
                245                 250         

<210>   1331
<211>   675
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1331
atgcaggatt cgggaatcca agtactcttt caaggaaata atctcctgag aatcttacag   60
ggattgggcg ttacgattgg gatatccatc ctgtctgtcc tcttatccat gatgttcaga   120
acagtcatgg gaatcatcat gacctcccat tctagaatca tacgattttt aacacgattg   180
tatctggaat ttatccgtat catgccccag ctggtgctac tcttcatcgt ttactttggc   240
ttggctcgaa actttaatat caatatctca ggtgagactt cagctattat cgtttttacc   300
ctctggggaa cagctgaaat gggagacttg gtacgtggag ctatcacttc tctccctaaa   360
catcagtttg aaagtggaca ggcactcggc ttgactaatg ttcaacttta ctaccacatc   420
atcatcccac aagtcttaag aagactgcta ccgcaggcta tcaatcttgt cactcggatg   480
attaaaacca cttcattagt tgttttgatt ggggttgtgg aagtgaccaa agttggacaa   540
caaatcatcg atagcaatcg cctgaccatc ccaactgctt cattttggat ttatggaacc   600
attctaatct tatatttcgc agtttgctac cctatttcca aactatccac tcacttagaa   660
aaacattgga gaaac                                                    675

<210>   1332
<211>   225
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902667 (e-123)

<400>   1332
Met Gln Asp Ser Gly Ile Gln Val Leu Phe Gln Gly Asn Asn Leu Leu 
1               5                   10                  15      

Arg Ile Leu Gln Gly Leu Gly Val Thr Ile Gly Ile Ser Ile Leu Ser 
            20                  25                  30          

Val Leu Leu Ser Met Met Phe Arg Thr Val Met Gly Ile Ile Met Thr 
        35                  40                  45              

Ser His Ser Arg Ile Ile Arg Phe Leu Thr Arg Leu Tyr Leu Glu Phe 
    50                  55                  60                  

Ile Arg Ile Met Pro Gln Leu Val Leu Leu Phe Ile Val Tyr Phe Gly 
65                  70                  75                  80  

Leu Ala Arg Asn Phe Asn Ile Asn Ile Ser Gly Glu Thr Ser Ala Ile 
                85                  90                  95      

Ile Val Phe Thr Leu Trp Gly Thr Ala Glu Met Gly Asp Leu Val Arg 
            100                 105                 110         

Gly Ala Ile Thr Ser Leu Pro Lys His Gln Phe Glu Ser Gly Gln Ala 
        115                 120                 125             

Leu Gly Leu Thr Asn Val Gln Leu Tyr Tyr His Ile Ile Ile Pro Gln 
    130                 135                 140                 

Val Leu Arg Arg Leu Leu Pro Gln Ala Ile Asn Leu Val Thr Arg Met 
145                 150                 155                 160 

Ile Lys Thr Thr Ser Leu Val Val Leu Ile Gly Val Val Glu Val Thr 
                165                 170                 175     

Lys Val Gly Gln Gln Ile Ile Asp Ser Asn Arg Leu Thr Ile Pro Thr 
            180                 185                 190         

Ala Ser Phe Trp Ile Tyr Gly Thr Ile Leu Ile Leu Tyr Phe Ala Val 
        195                 200                 205             

Cys Tyr Pro Ile Ser Lys Leu Ser Thr His Leu Glu Lys His Trp Arg 
    210                 215                 220                 

Asn 
225 

<210>   1333
<211>   618
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1333
ttgcatattg cagtttgggg aattttggga tcctttctgc tcggtttaat cgttagtatc   60
atccgacatt atcgaatcct tgttttggcg caagtagcga cagcctacat tgaattgtca   120
cgtaatacgc cccttttgat tcaactcttc tttctctact tcggtcttcc ccgaatcggg   180
attgtcctat cttcagaagt ctgtgcaacg cttgggcttg tctttttagg aggctcctat   240
atggcagaat ctttccgaag tgggctggaa gccatcagtc aaacccagca ggagattggc   300
ctcgctattg gtctgacacc tctacaggtc ttttactatg tggttcttcc gcaagcaaca   360
gcggtggcac tcccctcctt tagtgccaat gtcattttcc ttatcaagga aacctctgtt   420
ttctcagcag tggctttggc cgacctcatg tacgtcgcca aggatttgat tggtctctac   480
tatgagacag acattgcgct agctatgttg gtagttgctt atctaatcat gctgctaccc   540
atctcactgg tctttagctg gatagaaagg aggctccgcc atgcaggatt cgggaatcca   600
agtactcttt caaggaaa                                                 618

<210>   1334
<211>   206
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902668 (e-109)

<400>   1334
Met His Ile Ala Val Trp Gly Ile Leu Gly Ser Phe Leu Leu Gly Leu 
1               5                   10                  15      

Ile Val Ser Ile Ile Arg His Tyr Arg Ile Leu Val Leu Ala Gln Val 
            20                  25                  30          

Ala Thr Ala Tyr Ile Glu Leu Ser Arg Asn Thr Pro Leu Leu Ile Gln 
        35                  40                  45              

Leu Phe Phe Leu Tyr Phe Gly Leu Pro Arg Ile Gly Ile Val Leu Ser 
    50                  55                  60                  

Ser Glu Val Cys Ala Thr Leu Gly Leu Val Phe Leu Gly Gly Ser Tyr 
65                  70                  75                  80  

Met Ala Glu Ser Phe Arg Ser Gly Leu Glu Ala Ile Ser Gln Thr Gln 
                85                  90                  95      

Gln Glu Ile Gly Leu Ala Ile Gly Leu Thr Pro Leu Gln Val Phe Tyr 
            100                 105                 110         

Tyr Val Val Leu Pro Gln Ala Thr Ala Val Ala Leu Pro Ser Phe Ser 
        115                 120                 125             


Ala Asn Val Ile Phe Leu Ile Lys Glu Thr Ser Val Phe Ser Ala Val 
    130                 135                 140                 

Ala Leu Ala Asp Leu Met Tyr Val Ala Lys Asp Leu Ile Gly Leu Tyr 
145                 150                 155                 160 

Tyr Glu Thr Asp Ile Ala Leu Ala Met Leu Val Val Ala Tyr Leu Ile 
                165                 170                 175     

Met Leu Leu Pro Ile Ser Leu Val Phe Ser Trp Ile Glu Arg Arg Leu 
            180                 185                 190         

Arg His Ala Gly Phe Gly Asn Pro Ser Thr Leu Ser Arg Lys 
        195                 200                 205     

<210>   1335
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1335
atgtcataca aaacaagcaa tgcagaaggt catgtagatt tcatcaatac ctatgatttg   60
gagccaatgg cgcaacaagt tattcctaaa gcagcatttg gctatatcgc tagtggggcg   120
ggagatactt tcacttcttt ccag                                          144

<210>   1336
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lactate oxidase, truncation (lctO)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902669 (5.E-23)

<400>   1336
Met Ser Tyr Lys Thr Ser Asn Ala Glu Gly His Val Asp Phe Ile Asn 
1               5                   10                  15      

Thr Tyr Asp Leu Glu Pro Met Ala Gln Gln Val Ile Pro Lys Ala Ala 
            20                  25                  30          

Phe Gly Tyr Ile Ala Ser Gly Ala Gly Asp Thr Phe Thr Ser Phe Gln 
        35                  40                  45              


<210>   1337
<211>   1473
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1337
atggaagaac taaatgacca gcagatcgtt cgccgtgaaa aaatggctgc gctccgcgaa   60
caaggaatcg atcctttcgg aaaacgtttt gaacgtactg caaattcaca agaattaaaa   120
gataaatatg ccaacctcga taaagaacaa ttacacgata aaaacgaaac agctactatc   180
gcaggacgct tgataaccaa acgtggtaaa ggaaaagttg gttttgccca ccttcaagac   240
cgcgaaggcc agattcagat ctacgttcgt aaggatgctg tcggtgaaga aaactacgaa   300
atcttcaaaa aagcagacct tggtgacttc cttggtgtcg aaggtgaagt gatgcgtacg   360
gatatgggag aactctctat caaggcaacc cacatcacac acttgtctaa ggctcttcgt   420
cctcttcctg agaaattcca tggtttgaca gacgttgaaa caatttaccg taaacgttac   480
cttgacttga tttctaatcg tgaaagcttt gaacgctttg tcactcgttc aaaaatcatc   540
tctgaaatcc gtcgttacct tgaccaaaaa ggattccttg aagtggaaac acctgttctt   600
cataatgaag ccggtggtgc tgctgcccgt ccatttatca cccaccacaa tgcccaaaac   660
attgacatgg tgcttcgtat cgcgactgag cttcacttaa aacgccttat cgtgggtggt   720
atggaacgtg tctatgaaat tggccgtatc ttccgtaacg aaggaatgga cgctactcat   780
aaccctgagt tcacttctat cgaagtttac caagcttatg cagacttcca agacatcatg   840
gacttgactg aaggcattat ccaacacgct gctaaatcag tcaaaggtga tggcccagtc   900
aactaccaag gtactgaaat caagattaac gaaccattta agcgtgttca tatggtggat   960
gctatcagag aaattactgg tgtcgatttc tggcaagaca tgactttgga agaagctaaa   1020
gctatcgctg ctgagaagaa agttccagtt gagaaacact acactgaggt tggtcacatc   1080
atcaatgcct tctttgaaga gtttgttgaa gaaactttaa tccaaccaac ctttgtctat   1140
ggacatccag tagctgtatc tccactcgct aagaaaaatc ctgaagacca acgctttact   1200
gaccgtttcg agctctttat catgactaag gagtacggta atgcctttac tgagttgaac   1260
gacccaatcg accaacttag ccgttttgaa gcccaagcta aagccaaaga acttggtgat   1320
gatgaagcga caggaatcga ctatgactac attgaagctc ttgaatacgg tatgccacca   1380
acaggtggtt tgggaatcgg tatcgaccgt ctctgcatgc tcctcactga tacaacaact   1440
atccgtgatg tattgctctt cccaacaatg aaa                                1473

<210>   1338
<211>   491
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lysyl-tRNA synthetase (lysS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902670 (0.E+01)

<400>   1338
Met Glu Glu Leu Asn Asp Gln Gln Ile Val Arg Arg Glu Lys Met Ala 
1               5                   10                  15      

Ala Leu Arg Glu Gln Gly Ile Asp Pro Phe Gly Lys Arg Phe Glu Arg 
            20                  25                  30          

Thr Ala Asn Ser Gln Glu Leu Lys Asp Lys Tyr Ala Asn Leu Asp Lys 
        35                  40                  45              

Glu Gln Leu His Asp Lys Asn Glu Thr Ala Thr Ile Ala Gly Arg Leu 
    50                  55                  60                  

Ile Thr Lys Arg Gly Lys Gly Lys Val Gly Phe Ala His Leu Gln Asp 
65                  70                  75                  80  

Arg Glu Gly Gln Ile Gln Ile Tyr Val Arg Lys Asp Ala Val Gly Glu 
                85                  90                  95      

Glu Asn Tyr Glu Ile Phe Lys Lys Ala Asp Leu Gly Asp Phe Leu Gly 
            100                 105                 110         

Val Glu Gly Glu Val Met Arg Thr Asp Met Gly Glu Leu Ser Ile Lys 
        115                 120                 125             

Ala Thr His Ile Thr His Leu Ser Lys Ala Leu Arg Pro Leu Pro Glu 
    130                 135                 140                 

Lys Phe His Gly Leu Thr Asp Val Glu Thr Ile Tyr Arg Lys Arg Tyr 
145                 150                 155                 160 

Leu Asp Leu Ile Ser Asn Arg Glu Ser Phe Glu Arg Phe Val Thr Arg 
                165                 170                 175     

Ser Lys Ile Ile Ser Glu Ile Arg Arg Tyr Leu Asp Gln Lys Gly Phe 
            180                 185                 190         

Leu Glu Val Glu Thr Pro Val Leu His Asn Glu Ala Gly Gly Ala Ala 
        195                 200                 205             

Ala Arg Pro Phe Ile Thr His His Asn Ala Gln Asn Ile Asp Met Val 
    210                 215                 220                 

Leu Arg Ile Ala Thr Glu Leu His Leu Lys Arg Leu Ile Val Gly Gly 
225                 230                 235                 240 

Met Glu Arg Val Tyr Glu Ile Gly Arg Ile Phe Arg Asn Glu Gly Met 
                245                 250                 255     

Asp Ala Thr His Asn Pro Glu Phe Thr Ser Ile Glu Val Tyr Gln Ala 
            260                 265                 270         

Tyr Ala Asp Phe Gln Asp Ile Met Asp Leu Thr Glu Gly Ile Ile Gln 
        275                 280                 285             

His Ala Ala Lys Ser Val Lys Gly Asp Gly Pro Val Asn Tyr Gln Gly 
    290                 295                 300                 

Thr Glu Ile Lys Ile Asn Glu Pro Phe Lys Arg Val His Met Val Asp 
305                 310                 315                 320 

Ala Ile Arg Glu Ile Thr Gly Val Asp Phe Trp Gln Asp Met Thr Leu 
                325                 330                 335     

Glu Glu Ala Lys Ala Ile Ala Ala Glu Lys Lys Val Pro Val Glu Lys 
            340                 345                 350         

His Tyr Thr Glu Val Gly His Ile Ile Asn Ala Phe Phe Glu Glu Phe 
        355                 360                 365             

Val Glu Glu Thr Leu Ile Gln Pro Thr Phe Val Tyr Gly His Pro Val 
    370                 375                 380                 

Ala Val Ser Pro Leu Ala Lys Lys Asn Pro Glu Asp Gln Arg Phe Thr 
385                 390                 395                 400 

Asp Arg Phe Glu Leu Phe Ile Met Thr Lys Glu Tyr Gly Asn Ala Phe 
                405                 410                 415     

Thr Glu Leu Asn Asp Pro Ile Asp Gln Leu Ser Arg Phe Glu Ala Gln 
            420                 425                 430         

Ala Lys Ala Lys Glu Leu Gly Asp Asp Glu Ala Thr Gly Ile Asp Tyr 
        435                 440                 445             

Asp Tyr Ile Glu Ala Leu Glu Tyr Gly Met Pro Pro Thr Gly Gly Leu 
    450                 455                 460                 

Gly Ile Gly Ile Asp Arg Leu Cys Met Leu Leu Thr Asp Thr Thr Thr 
465                 470                 475                 480 

Ile Arg Asp Val Leu Leu Phe Pro Thr Met Lys 
                485                 490     

<210>   1339
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1339
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattgtt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg tgggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   1340
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   1340
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   1341
<211>   1134
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1341
atgtcataca aaacaagcaa tgcagaaggt catgtagact tcatcaatac ctatgatttg   60
gagccaatgg cgcaacaagt tattcctaaa gcagcatttg gctatatcgc tagtggggcg   120
gaagatactt tcactttaag agagaatatc cgtgccttta accacaagct catcgttcct   180
catacacttt gcaatgtaga aaatccaagt acagagattg aatttgcagg tgaaaaacta   240
tcttctccaa tcattatggc acctgttgcg gctcataaat tggcaaatga acagggggaa   300
gtggcgactg cgcgtggtgt gcatgagttt ggttctcttt atacaaccag ttcttactct   360
actgttgacc ttccagagat ttctgaagcc ctccaaggga cacctcattg gtttcaattt   420
tactttagta aggatgacgg tatcaaccgc cacatcatgg accgtgtgaa ggctgaaggt   480
tataaagcga ttgtcttgac ggcagatgct actgtagggg ggaatcgtga agtggataag   540
cgtaatggtt ttgtcttccc agttggcatg ccgattgttg aagaatacct gccagaaggt   600
gctggtaaat caatggactt tgtttacaaa tcagctaaac aacgcttgtc tccacgcgat   660
gtagaattta tcgctgaata ctctggtctt cctgtgtatg tcaagggacc acaatgccgt   720
gaggacgttg aacgttcgct tgctgcagga gcttctggta tctgggtaac caaccacggt   780
ggtcgtcaaa tcgacggtgg accagctgcc tttgactcgc ttcaagaagt ggcagaagca   840
gttgatagac gtgtgccgat tgtctttgac tctggtgttc gtcgtggtca acacgtcttt   900
aaagccttgg catcaggagc agacttggtt gctattggac gccctgtcat ctatggcttg   960
gctctcggtg gtagtgtcgg tgtgcgtcaa gtctttgaac acttgaatgc ggaattgaag   1020
acagttatgc aattgtctgg aactcagacc attgaagatg tcaaacactt caagctccgt   1080
cacaatccat acaacccaac cttcccagtt gaccctcgtg acttaaaatt gtat         1134

<210>   1342
<211>   378
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lactate oxidase (lctO)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902671 (0.E+01)

<400>   1342
Met Ser Tyr Lys Thr Ser Asn Ala Glu Gly His Val Asp Phe Ile Asn 
1               5                   10                  15      

Thr Tyr Asp Leu Glu Pro Met Ala Gln Gln Val Ile Pro Lys Ala Ala 
            20                  25                  30          

Phe Gly Tyr Ile Ala Ser Gly Ala Glu Asp Thr Phe Thr Leu Arg Glu 
        35                  40                  45              

Asn Ile Arg Ala Phe Asn His Lys Leu Ile Val Pro His Thr Leu Cys 
    50                  55                  60                  

Asn Val Glu Asn Pro Ser Thr Glu Ile Glu Phe Ala Gly Glu Lys Leu 
65                  70                  75                  80  

Ser Ser Pro Ile Ile Met Ala Pro Val Ala Ala His Lys Leu Ala Asn 
                85                  90                  95      

Glu Gln Gly Glu Val Ala Thr Ala Arg Gly Val His Glu Phe Gly Ser 
            100                 105                 110         

Leu Tyr Thr Thr Ser Ser Tyr Ser Thr Val Asp Leu Pro Glu Ile Ser 
        115                 120                 125             

Glu Ala Leu Gln Gly Thr Pro His Trp Phe Gln Phe Tyr Phe Ser Lys 
    130                 135                 140                 

Asp Asp Gly Ile Asn Arg His Ile Met Asp Arg Val Lys Ala Glu Gly 
145                 150                 155                 160 

Tyr Lys Ala Ile Val Leu Thr Ala Asp Ala Thr Val Gly Gly Asn Arg 
                165                 170                 175     

Glu Val Asp Lys Arg Asn Gly Phe Val Phe Pro Val Gly Met Pro Ile 
            180                 185                 190         

Val Glu Glu Tyr Leu Pro Glu Gly Ala Gly Lys Ser Met Asp Phe Val 
        195                 200                 205             

Tyr Lys Ser Ala Lys Gln Arg Leu Ser Pro Arg Asp Val Glu Phe Ile 
    210                 215                 220                 

Ala Glu Tyr Ser Gly Leu Pro Val Tyr Val Lys Gly Pro Gln Cys Arg 
225                 230                 235                 240 

Glu Asp Val Glu Arg Ser Leu Ala Ala Gly Ala Ser Gly Ile Trp Val 
                245                 250                 255     

Thr Asn His Gly Gly Arg Gln Ile Asp Gly Gly Pro Ala Ala Phe Asp 
            260                 265                 270         

Ser Leu Gln Glu Val Ala Glu Ala Val Asp Arg Arg Val Pro Ile Val 
        275                 280                 285             

Phe Asp Ser Gly Val Arg Arg Gly Gln His Val Phe Lys Ala Leu Ala 
    290                 295                 300                 

Ser Gly Ala Asp Leu Val Ala Ile Gly Arg Pro Val Ile Tyr Gly Leu 
305                 310                 315                 320 

Ala Leu Gly Gly Ser Val Gly Val Arg Gln Val Phe Glu His Leu Asn 
                325                 330                 335     

Ala Glu Leu Lys Thr Val Met Gln Leu Ser Gly Thr Gln Thr Ile Glu 
            340                 345                 350         

Asp Val Lys His Phe Lys Leu Arg His Asn Pro Tyr Asn Pro Thr Phe 
        355                 360                 365             

Pro Val Asp Pro Arg Asp Leu Lys Leu Tyr 
    370                 375             

<210>   1343
<211>   666
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1343
atggaaacac aagactatgc atttcagcca ggtttgactg ttggagaatt attaaaaagc   60
agtcagaagg attggcaggc tgcaatcaat catcgttttg ttaaggaact ttttgcgggg   120
acaattgaga ataaggtctt aaaggactat ctgattcaag attatcactt ctttgatgcc   180
ttcttatcca tgctgggtgc ctgcgtagct cacgcagata aacttgaatc caagcttcgt   240
tttgccaagc aactaggctt tcttgaagca gatgaagatg gttatttcca aaaggctttt   300
aaagagttaa aagtagcaga gaatgactat ctagaagtga ctttgcaccc tgtaacaaaa   360
gcctttcagg atctaatgta ttcggcggtg gcttcatcag actatgccca tcttttggtc   420
atgctggtca ttgcagaagg tctctattta gactggggtt ctaaagattt ggctttacct   480
gaagtctata ttcattcgga atggatcaat ctccacagag gtcctttctt tgcagagtgg   540
gttcaatttc tggttgacga actcaatcgt gtcggtaaaa atcgagaaga tttgacagaa   600
cttcagcaac gctggaatca agcagtcgct ttagaattag ctttttttga tattggttac   660
gatgtc                                                              666

<210>   1344
<211>   222
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902672 (e-128)

<400>   1344
Met Glu Thr Gln Asp Tyr Ala Phe Gln Pro Gly Leu Thr Val Gly Glu 
1               5                   10                  15      

Leu Leu Lys Ser Ser Gln Lys Asp Trp Gln Ala Ala Ile Asn His Arg 
            20                  25                  30          

Phe Val Lys Glu Leu Phe Ala Gly Thr Ile Glu Asn Lys Val Leu Lys 
        35                  40                  45              

Asp Tyr Leu Ile Gln Asp Tyr His Phe Phe Asp Ala Phe Leu Ser Met 
    50                  55                  60                  

Leu Gly Ala Cys Val Ala His Ala Asp Lys Leu Glu Ser Lys Leu Arg 
65                  70                  75                  80  

Phe Ala Lys Gln Leu Gly Phe Leu Glu Ala Asp Glu Asp Gly Tyr Phe 
                85                  90                  95      

Gln Lys Ala Phe Lys Glu Leu Lys Val Ala Glu Asn Asp Tyr Leu Glu 
            100                 105                 110         

Val Thr Leu His Pro Val Thr Lys Ala Phe Gln Asp Leu Met Tyr Ser 
        115                 120                 125             

Ala Val Ala Ser Ser Asp Tyr Ala His Leu Leu Val Met Leu Val Ile 
    130                 135                 140                 

Ala Glu Gly Leu Tyr Leu Asp Trp Gly Ser Lys Asp Leu Ala Leu Pro 
145                 150                 155                 160 

Glu Val Tyr Ile His Ser Glu Trp Ile Asn Leu His Arg Gly Pro Phe 
                165                 170                 175     

Phe Ala Glu Trp Val Gln Phe Leu Val Asp Glu Leu Asn Arg Val Gly 
            180                 185                 190         

Lys Asn Arg Glu Asp Leu Thr Glu Leu Gln Gln Arg Trp Asn Gln Ala 
        195                 200                 205             

Val Ala Leu Glu Leu Ala Phe Phe Asp Ile Gly Tyr Asp Val 
    210                 215                 220         

<210>   1345
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1345
gtgaaaagga aggatttcaa tatgacaagt ttaaaattat taaaagaaaa agcaccattg   60
gtcatttgta taaccaatga tgtagtaaaa aatttcacag caaatggatt agtagcactg   120
ggcgcctcac cagccatgag tgagtttcca gcagatttag aggatttgtt aaagtatgct   180
ggtggtttat taataaacat aggaacattg acagatgaaa attggaaatt ataccaagct   240
gctctgaaaa ttgcagagaa atataatgtc ccagcagttt tagatcctgt agcctgtgga   300
gcaggagaat atagaaaaaa agtagcagat gatctaatca acaattataa actagcagcg   360
attagaggaa atgctggcga gattgcctct ttagtaggaa tagatgtggc atctaaagga   420
gtagatagtg cgggcgtaga taatattgac gaaattgctc tagcagcaaa tgagaagttc   480
aatattccaa tagtagtaac aggtgaagtg gatgccattg ctgttaatgg agaagtggta   540
atgattcata atggtagtgc tatgatgccg aaagtcattg ggacaggatg cttattagga   600
gctgtagtag caagctttat cggactagaa aaaggtcaag aattgaaatc attaaaaaca   660
gcagtgttgg tttacaatat cgctggagaa atagcagaaa aacgtccaaa tggacatctt   720
cctgggacat ttaaagttga atttataaat gccttatacg agattacaga tgaagatgta   780
aaggaattca aaagagtgaa g                                             801

<210>   1346
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydroxyethylthiazole kinase (thiM)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902673 (e-143)

<400>   1346
Met Lys Arg Lys Asp Phe Asn Met Thr Ser Leu Lys Leu Leu Lys Glu 
1               5                   10                  15      

Lys Ala Pro Leu Val Ile Cys Ile Thr Asn Asp Val Val Lys Asn Phe 
            20                  25                  30          

Thr Ala Asn Gly Leu Val Ala Leu Gly Ala Ser Pro Ala Met Ser Glu 
        35                  40                  45              

Phe Pro Ala Asp Leu Glu Asp Leu Leu Lys Tyr Ala Gly Gly Leu Leu 
    50                  55                  60                  

Ile Asn Ile Gly Thr Leu Thr Asp Glu Asn Trp Lys Leu Tyr Gln Ala 
65                  70                  75                  80  

Ala Leu Lys Ile Ala Glu Lys Tyr Asn Val Pro Ala Val Leu Asp Pro 
                85                  90                  95      

Val Ala Cys Gly Ala Gly Glu Tyr Arg Lys Lys Val Ala Asp Asp Leu 
            100                 105                 110         

Ile Asn Asn Tyr Lys Leu Ala Ala Ile Arg Gly Asn Ala Gly Glu Ile 
        115                 120                 125             

Ala Ser Leu Val Gly Ile Asp Val Ala Ser Lys Gly Val Asp Ser Ala 
    130                 135                 140                 

Gly Val Asp Asn Ile Asp Glu Ile Ala Leu Ala Ala Asn Glu Lys Phe 
145                 150                 155                 160 

Asn Ile Pro Ile Val Val Thr Gly Glu Val Asp Ala Ile Ala Val Asn 
                165                 170                 175     

Gly Glu Val Val Met Ile His Asn Gly Ser Ala Met Met Pro Lys Val 
            180                 185                 190         

Ile Gly Thr Gly Cys Leu Leu Gly Ala Val Val Ala Ser Phe Ile Gly 
        195                 200                 205             

Leu Glu Lys Gly Gln Glu Leu Lys Ser Leu Lys Thr Ala Val Leu Val 
    210                 215                 220                 

Tyr Asn Ile Ala Gly Glu Ile Ala Glu Lys Arg Pro Asn Gly His Leu 
225                 230                 235                 240 

Pro Gly Thr Phe Lys Val Glu Phe Ile Asn Ala Leu Tyr Glu Ile Thr 
                245                 250                 255     

Asp Glu Asp Val Lys Glu Phe Lys Arg Val Lys 
            260                 265         

<210>   1347
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1347
atgtttcata aagaattact aaaactatat tttatttgtg gaacgactac ttgccaagga   60
aaaaatctat atacagtcgt tgaggaagcc ttaaaaggtg gtataacctt atttcaattt   120
cgagaaaaag gtgagggtgc tttagaaggc ttagaaaaac ttgagctagc tatccaaatt   180
aaagaacttt gtaaaaaata caatgttcca tttatcgtta atgacgatat agatttagca   240
atggaaattg acgccgatgg cgtacatgta ggtcaagatg atattggtgt tgatgaaatt   300
agaaaattga tgccagataa aataattggt ctttctataa gaaacgaaga agaatttcaa   360
caatcaaaag ttgaatatgt agattatgta ggtgttgggc ctgtatttgg tacccagtca   420
aaggatgatg ctggtggtac tataggttat gaaggtcttg aattgatgag aaaactattg   480
ccacaaatgc ctttagttgc aattggtggg atacagacga aacatattaa agacattata   540
aagaccaata tggatggcgt ttcaatcatt tcggcaatat cgtatgcaaa aaatatagaa   600
aaaactgttc gggaaatgag tgaacaa                                       627

<210>   1348
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thiamine-phosphate pyrophosphorylase (thiE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902674 (e-115)

<400>   1348
Met Phe His Lys Glu Leu Leu Lys Leu Tyr Phe Ile Cys Gly Thr Thr 
1               5                   10                  15      

Thr Cys Gln Gly Lys Asn Leu Tyr Thr Val Val Glu Glu Ala Leu Lys 
            20                  25                  30          

Gly Gly Ile Thr Leu Phe Gln Phe Arg Glu Lys Gly Glu Gly Ala Leu 
        35                  40                  45              

Glu Gly Leu Glu Lys Leu Glu Leu Ala Ile Gln Ile Lys Glu Leu Cys 
    50                  55                  60                  

Lys Lys Tyr Asn Val Pro Phe Ile Val Asn Asp Asp Ile Asp Leu Ala 
65                  70                  75                  80  

Met Glu Ile Asp Ala Asp Gly Val His Val Gly Gln Asp Asp Ile Gly 
                85                  90                  95      

Val Asp Glu Ile Arg Lys Leu Met Pro Asp Lys Ile Ile Gly Leu Ser 
            100                 105                 110         

Ile Arg Asn Glu Glu Glu Phe Gln Gln Ser Lys Val Glu Tyr Val Asp 
        115                 120                 125             

Tyr Val Gly Val Gly Pro Val Phe Gly Thr Gln Ser Lys Asp Asp Ala 
    130                 135                 140                 

Gly Gly Thr Ile Gly Tyr Glu Gly Leu Glu Leu Met Arg Lys Leu Leu 
145                 150                 155                 160 

Pro Gln Met Pro Leu Val Ala Ile Gly Gly Ile Gln Thr Lys His Ile 
                165                 170                 175     

Lys Asp Ile Ile Lys Thr Asn Met Asp Gly Val Ser Ile Ile Ser Ala 
            180                 185                 190         

Ile Ser Tyr Ala Lys Asn Ile Glu Lys Thr Val Arg Glu Met Ser Glu 
        195                 200                 205             

Gln 
    

<210>   1349
<211>   558
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1349
atgttgaaaa aatggcagtt aaaagatgtt atcttgcttg ctttcttgtc tatctttttt   60
ggtggggttt tcgttggttc aggatatgtg tataatattc tcagtctact cttaacacct   120
cttggtttgc aggcctttgc caatgaaatc ctcttcggtc tctggtgtat ggctgcgccc   180
attgctgcca tctttgttcc gagagtcgga agtgcaacga ttggagaagt gctagctgcg   240
cttgctgaag tcctttatgg tagccaattt ggtctaggag ctcttttgtc tggctttgtt   300
caaggtttgg gaagtgaatt tggttttatc gtaactaaga atcgctatga aagttggctc   360
tctctaactg ctaatagtat tgggattacg cttgttagct ttgtctatga atacattaag   420
ttaggttact acgccttttc ccttccgttt gtcctttcct tgcttgtggt acgttttatt   480
tctgtttatt tcttctgtac catcttggtt cgtgccattg tcaaactcta tcatcagttt   540
gcaactggag gaaaagca                                                 558

<210>   1350
<211>   186
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902675 (e-101)

<400>   1350
Met Leu Lys Lys Trp Gln Leu Lys Asp Val Ile Leu Leu Ala Phe Leu 
1               5                   10                  15      

Ser Ile Phe Phe Gly Gly Val Phe Val Gly Ser Gly Tyr Val Tyr Asn 
            20                  25                  30          

Ile Leu Ser Leu Leu Leu Thr Pro Leu Gly Leu Gln Ala Phe Ala Asn 
        35                  40                  45              

Glu Ile Leu Phe Gly Leu Trp Cys Met Ala Ala Pro Ile Ala Ala Ile 
    50                  55                  60                  

Phe Val Pro Arg Val Gly Ser Ala Thr Ile Gly Glu Val Leu Ala Ala 
65                  70                  75                  80  

Leu Ala Glu Val Leu Tyr Gly Ser Gln Phe Gly Leu Gly Ala Leu Leu 
                85                  90                  95      

Ser Gly Phe Val Gln Gly Leu Gly Ser Glu Phe Gly Phe Ile Val Thr 
            100                 105                 110         

Lys Asn Arg Tyr Glu Ser Trp Leu Ser Leu Thr Ala Asn Ser Ile Gly 
        115                 120                 125             

Ile Thr Leu Val Ser Phe Val Tyr Glu Tyr Ile Lys Leu Gly Tyr Tyr 
    130                 135                 140                 

Ala Phe Ser Leu Pro Phe Val Leu Ser Leu Leu Val Val Arg Phe Ile 
145                 150                 155                 160 

Ser Val Tyr Phe Phe Cys Thr Ile Leu Val Arg Ala Ile Val Lys Leu 
                165                 170                 175     

Tyr His Gln Phe Ala Thr Gly Gly Lys Ala 
            180                 185     

<210>   1351
<211>   1383
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1351
atgggtctgg aactacgagc gattcagtcc ccaatcttct ctgagccgtt tgattttact   60
tttcatgcgc aagcctttac cttgttagtt gggagtagtg ggtctggaaa atccagcctc   120
tttcaaatga ttgcccaagt tagttctctt ccctatagcg gtcaagtcct gatagatggg   180
agcgaggtca gtcagctttc tatcgtcgaa cgtgtccaga cggttggtat tctcttgcaa   240
aatcctaatc atcaatttac catggagagc ttgtttgagg agttggtttt taccatggaa   300
aatatcggct atcaccttca ggaaattgat tctaaaatag cagaggttgt ccagcaatgt   360
cgttgcaagg acatcttgca ccgtctcatc catcacttat caggtgggga aaagcaaaaa   420
gcagcgctgg ctgtcctctt tgccatgaat cctagggtct atctcttgga tgagcccttc   480
gcttccattg accgcaagag cagaatcgag atattggaga ttctaaaaga gttggtctat   540
gatgggaaga cagttatttt gtgcgaccat gatttatctg actataaagc ctatatcgac   600
catatggtgg agctaagaga cggaaaacta agggaagtgt ttcaaatccc ttcctatgag   660
atgacacagg ttgcttcaaa ggaagttgct tctagcccgg aactattcca tatgaaccgt   720
gtgactggtg agcttggtaa tcgccccctc ttttcaattg ctgatttcac attctatcaa   780
gggatttcct gtatcctggg tgacaatggt gtcgggaaat caaccctctt tcggtctatt   840
cttcaatttc aaaagtataa ggggagcatt acttggaagg gttcggtcct gaaaaagaaa   900
aagagtttgt atcgtgatct gactggtgtt gttcaggaag ctgagaagca gtttatccga   960
gtcagtctgc gagaggagct tcaattagat ggacctgatt ctgaaagaaa tcagcggatt   1020
tttcaagctt tacgatattt tgatttggag caggcagtcg ataagagtcc ctatcaatta   1080
agtggtggtc agcaaaaaat tcttcagctc ctgaccatct tgaccagtaa ggcttccgtg   1140
atcttgctag atgaaccttt tgcaggtttg gatgatagag cctgccatta tttttgcaag   1200
tggattgtgg aggagaggaa tcaaggaaga agttttctgc tcattagtca tcgtttagac   1260
cctttgattt ctgtggttga ttattggatt gagatgacta gtcagggtct tcggcatgtg   1320
aaagaagtga ccattaccaa accacttaca tctcagagta gcaataccca aggggaggtg   1380
aga                                                                 1383

<210>   1352
<211>   461
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902676 (0.E+01)

<400>   1352
Met Gly Leu Glu Leu Arg Ala Ile Gln Ser Pro Ile Phe Ser Glu Pro 
1               5                   10                  15      

Phe Asp Phe Thr Phe His Ala Gln Ala Phe Thr Leu Leu Val Gly Ser 
            20                  25                  30          

Ser Gly Ser Gly Lys Ser Ser Leu Phe Gln Met Ile Ala Gln Val Ser 
        35                  40                  45              

Ser Leu Pro Tyr Ser Gly Gln Val Leu Ile Asp Gly Ser Glu Val Ser 
    50                  55                  60                  

Gln Leu Ser Ile Val Glu Arg Val Gln Thr Val Gly Ile Leu Leu Gln 
65                  70                  75                  80  

Asn Pro Asn His Gln Phe Thr Met Glu Ser Leu Phe Glu Glu Leu Val 
                85                  90                  95      

Phe Thr Met Glu Asn Ile Gly Tyr His Leu Gln Glu Ile Asp Ser Lys 
            100                 105                 110         

Ile Ala Glu Val Val Gln Gln Cys Arg Cys Lys Asp Ile Leu His Arg 
        115                 120                 125             

Leu Ile His His Leu Ser Gly Gly Glu Lys Gln Lys Ala Ala Leu Ala 
    130                 135                 140                 

Val Leu Phe Ala Met Asn Pro Arg Val Tyr Leu Leu Asp Glu Pro Phe 
145                 150                 155                 160 

Ala Ser Ile Asp Arg Lys Ser Arg Ile Glu Ile Leu Glu Ile Leu Lys 
                165                 170                 175     

Glu Leu Val Tyr Asp Gly Lys Thr Val Ile Leu Cys Asp His Asp Leu 
            180                 185                 190         

Ser Asp Tyr Lys Ala Tyr Ile Asp His Met Val Glu Leu Arg Asp Gly 
        195                 200                 205             

Lys Leu Arg Glu Val Phe Gln Ile Pro Ser Tyr Glu Met Thr Gln Val 
    210                 215                 220                 

Ala Ser Lys Glu Val Ala Ser Ser Pro Glu Leu Phe His Met Asn Arg 
225                 230                 235                 240 

Val Thr Gly Glu Leu Gly Asn Arg Pro Leu Phe Ser Ile Ala Asp Phe 
                245                 250                 255     

Thr Phe Tyr Gln Gly Ile Ser Cys Ile Leu Gly Asp Asn Gly Val Gly 
            260                 265                 270         

Lys Ser Thr Leu Phe Arg Ser Ile Leu Gln Phe Gln Lys Tyr Lys Gly 
        275                 280                 285             

Ser Ile Thr Trp Lys Gly Ser Val Leu Lys Lys Lys Lys Ser Leu Tyr 
    290                 295                 300                 

Arg Asp Leu Thr Gly Val Val Gln Glu Ala Glu Lys Gln Phe Ile Arg 
305                 310                 315                 320 

Val Ser Leu Arg Glu Glu Leu Gln Leu Asp Gly Pro Asp Ser Glu Arg 
                325                 330                 335     

Asn Gln Arg Ile Phe Gln Ala Leu Arg Tyr Phe Asp Leu Glu Gln Ala 
            340                 345                 350         

Val Asp Lys Ser Pro Tyr Gln Leu Ser Gly Gly Gln Gln Lys Ile Leu 
        355                 360                 365             

Gln Leu Leu Thr Ile Leu Thr Ser Lys Ala Ser Val Ile Leu Leu Asp 
    370                 375                 380                 

Glu Pro Phe Ala Gly Leu Asp Asp Arg Ala Cys His Tyr Phe Cys Lys 
385                 390                 395                 400 

Trp Ile Val Glu Glu Arg Asn Gln Gly Arg Ser Phe Leu Leu Ile Ser 
                405                 410                 415     

His Arg Leu Asp Pro Leu Ile Ser Val Val Asp Tyr Trp Ile Glu Met 
            420                 425                 430         

Thr Ser Gln Gly Leu Arg His Val Lys Glu Val Thr Ile Thr Lys Pro 
        435                 440                 445             

Leu Thr Ser Gln Ser Ser Asn Thr Gln Gly Glu Val Arg 
    450                 455                 460     

<210>   1353
<211>   648
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1353
atggtcaaag tagcaaccca gacaccgatt atcagtctct tcttgctgat tttatccttg   60
gaaacatctt tcattccttc gattgctctg actctttcgg tagtcgcatt ttgtattctc   120
tttatgctct attaccgtcg atttaaaatg ttagcttgga tgatcatact tgccatttta   180
ccatcttttg ccaactactg ggcagttcag ttacacggag atgcttcaca ggcagtcatg   240
cttggaacga gggcctttgt gacagtttgt atcggccttg tctttgtttc ctctgtttca   300
ctaaaagagc ttctcttgta cttggctcaa aaggggctat cacgctcttg gtcctatgcc   360
ttgattgtgg tattcaattc ttttcctctc attcagcaag aaatcaagtc cctcaaagaa   420
gcttgcctat tacgtggtca agaactacat ttttggtcgc ccttgattta cagtaaggtt   480
ctgatgacag tctttaggtg gcgccatctt tacctgagag ctctatctgc tcacggatat   540
gacgaacatg cacagttgaa gaatagctat cggacttttt atattcctaa aaaaacaaaa   600
ttaatctacc tgcttttctt tttattgctt caaaccagtc tattttta                648

<210>   1354
<211>   216
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902677 (e-120)

<400>   1354
Met Val Lys Val Ala Thr Gln Thr Pro Ile Ile Ser Leu Phe Leu Leu 
1               5                   10                  15      

Ile Leu Ser Leu Glu Thr Ser Phe Ile Pro Ser Ile Ala Leu Thr Leu 
            20                  25                  30          

Ser Val Val Ala Phe Cys Ile Leu Phe Met Leu Tyr Tyr Arg Arg Phe 
        35                  40                  45              

Lys Met Leu Ala Trp Met Ile Ile Leu Ala Ile Leu Pro Ser Phe Ala 
    50                  55                  60                  

Asn Tyr Trp Ala Val Gln Leu His Gly Asp Ala Ser Gln Ala Val Met 
65                  70                  75                  80  

Leu Gly Thr Arg Ala Phe Val Thr Val Cys Ile Gly Leu Val Phe Val 
                85                  90                  95      

Ser Ser Val Ser Leu Lys Glu Leu Leu Leu Tyr Leu Ala Gln Lys Gly 
            100                 105                 110         

Leu Ser Arg Ser Trp Ser Tyr Ala Leu Ile Val Val Phe Asn Ser Phe 
        115                 120                 125             

Pro Leu Ile Gln Gln Glu Ile Lys Ser Leu Lys Glu Ala Cys Leu Leu 
    130                 135                 140                 

Arg Gly Gln Glu Leu His Phe Trp Ser Pro Leu Ile Tyr Ser Lys Val 
145                 150                 155                 160 

Leu Met Thr Val Phe Arg Trp Arg His Leu Tyr Leu Arg Ala Leu Ser 
                165                 170                 175     

Ala His Gly Tyr Asp Glu His Ala Gln Leu Lys Asn Ser Tyr Arg Thr 
            180                 185                 190         

Phe Tyr Ile Pro Lys Lys Thr Lys Leu Ile Tyr Leu Leu Phe Phe Leu 
        195                 200                 205             

Leu Leu Gln Thr Ser Leu Phe Leu 
    210                 215     

<210>   1355
<211>   690
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1355
atggaattta cagatattgc gatggaatta tccaagaaag cttggcaggc ttcctttcat   60
catcccttta ttttacaatt acaagagggg aatttagaac ctgccatttt ccgctattac   120
ctgattcagg atgcctacta tctgaaggct ttctcagaaa tctatcatct tttggctgat   180
aagacttcaa accaagagat gaaaagactc ttgaaacaaa atgctcaggg tttagtggag   240
ggtgagttat ttattcgcca acaatttttc aaggaattgg aaatcagcga ccaggaaatg   300
gagcaacatc caatcgctcc aacctgttat cattacattt ctcatattta taggcaattt   360
gcagaaccga acttagccat cgcttttgca agcttgcttc cttgtccttg gttataccat   420
gatataggca aatcacttaa tcttaaacca tcaccaaatc ctctctatca acaatggatt   480
gaaacttata ttacggatga gttagagcaa cagatcagag aggagggagc actggtcaat   540
cagctctatc gagaaagtga cgagacagac aagcaaaaaa tgctagatgc cttccacatc   600
agtgttcata tggaagccaa gttttgggaa atggcctacc aacaccagac atggaagagc   660
gatttacagt ctttagaaaa aggagaagaa                                    690

<210>   1356
<211>   230
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional activator TenA (tenA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902678 (e-135)

<400>   1356
Met Glu Phe Thr Asp Ile Ala Met Glu Leu Ser Lys Lys Ala Trp Gln 
1               5                   10                  15      

Ala Ser Phe His His Pro Phe Ile Leu Gln Leu Gln Glu Gly Asn Leu 
            20                  25                  30          

Glu Pro Ala Ile Phe Arg Tyr Tyr Leu Ile Gln Asp Ala Tyr Tyr Leu 
        35                  40                  45              

Lys Ala Phe Ser Glu Ile Tyr His Leu Leu Ala Asp Lys Thr Ser Asn 
    50                  55                  60                  

Gln Glu Met Lys Arg Leu Leu Lys Gln Asn Ala Gln Gly Leu Val Glu 
65                  70                  75                  80  

Gly Glu Leu Phe Ile Arg Gln Gln Phe Phe Lys Glu Leu Glu Ile Ser 
                85                  90                  95      

Asp Gln Glu Met Glu Gln His Pro Ile Ala Pro Thr Cys Tyr His Tyr 
            100                 105                 110         

Ile Ser His Ile Tyr Arg Gln Phe Ala Glu Pro Asn Leu Ala Ile Ala 
        115                 120                 125             

Phe Ala Ser Leu Leu Pro Cys Pro Trp Leu Tyr His Asp Ile Gly Lys 
    130                 135                 140                 

Ser Leu Asn Leu Lys Pro Ser Pro Asn Pro Leu Tyr Gln Gln Trp Ile 
145                 150                 155                 160 

Glu Thr Tyr Ile Thr Asp Glu Leu Glu Gln Gln Ile Arg Glu Glu Gly 
                165                 170                 175     

Ala Leu Val Asn Gln Leu Tyr Arg Glu Ser Asp Glu Thr Asp Lys Gln 
            180                 185                 190         

Lys Met Leu Asp Ala Phe His Ile Ser Val His Met Glu Ala Lys Phe 
        195                 200                 205             

Trp Glu Met Ala Tyr Gln His Gln Thr Trp Lys Ser Asp Leu Gln Ser 
    210                 215                 220                 

Leu Glu Lys Gly Glu Glu 
225                 230 

<210>   1357
<211>   522
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1357
atgagaaagc accaattaca agttcacaaa ttaaccattt tatctatgat gattgccctt   60
gatgtagtcc ttacacctat ctttcgaatt gagggaatgg caccgatgtc cagtgtagtc   120
aatattctag caggaatcat gatgggacct gtttatgcct tggctatggc tacagtcaca   180
gcctttatcc gtatgacgac tcaagggatt ccgcctttag ctctcacagg agcgactttt   240
ggagcccttc tagcaggtct cttttataag tacggtcgaa aatttcacta ttctgctcta   300
ggagagattt tgggaacagg tattattggt tccattgttt cctatcctgt tatggtactc   360
tttacaggat cagctgctaa gcttagctgg tttatctaca cgcctcgatt tttcggagca   420
accttgattg gtacagcgat ttcctttatt gcctttcgat ttttaatcaa gcaggaattc   480
tttaaaaaag tgcagggata tttctttagt gaaaggatag ac                      522

<210>   1358
<211>   174
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902679 (1.E-95)

<400>   1358
Met Arg Lys His Gln Leu Gln Val His Lys Leu Thr Ile Leu Ser Met 
1               5                   10                  15      

Met Ile Ala Leu Asp Val Val Leu Thr Pro Ile Phe Arg Ile Glu Gly 
            20                  25                  30          

Met Ala Pro Met Ser Ser Val Val Asn Ile Leu Ala Gly Ile Met Met 
        35                  40                  45              

Gly Pro Val Tyr Ala Leu Ala Met Ala Thr Val Thr Ala Phe Ile Arg 
    50                  55                  60                  

Met Thr Thr Gln Gly Ile Pro Pro Leu Ala Leu Thr Gly Ala Thr Phe 
65                  70                  75                  80  

Gly Ala Leu Leu Ala Gly Leu Phe Tyr Lys Tyr Gly Arg Lys Phe His 
                85                  90                  95      

Tyr Ser Ala Leu Gly Glu Ile Leu Gly Thr Gly Ile Ile Gly Ser Ile 
            100                 105                 110         

Val Ser Tyr Pro Val Met Val Leu Phe Thr Gly Ser Ala Ala Lys Leu 
        115                 120                 125             

Ser Trp Phe Ile Tyr Thr Pro Arg Phe Phe Gly Ala Thr Leu Ile Gly 
    130                 135                 140                 

Thr Ala Ile Ser Phe Ile Ala Phe Arg Phe Leu Ile Lys Gln Glu Phe 
145                 150                 155                 160 

Phe Lys Lys Val Gln Gly Tyr Phe Phe Ser Glu Arg Ile Asp 
                165                 170                 

<210>   1359
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1359
atgcaggaat ttacaaatcc ctttcctata ggctctagtt ccctcattca ctgcattacc   60
aatgagattt cttgtgagat gctggcaaat gggattttgg ctctgggatg caaacctgtc   120
atggcagatg attcccgtga agttcttgat tttactaagc aaagtcaggc tctcttcatc   180
aatttggggc atttgtcagc tgagaaggaa aaagcaatcc gcatggcagc ttcgtatgca   240
aaccaatctt ctctcccgat ggtagtagat gcggttggcg taacgacttc atccattcgt   300
aagagcttag ttaaagacct tttagactat agacctacgg tccttaaagg aaacatgtca   360
gaaattcgaa gtcttgttgg attaaagcac cacggcgttg gggtcgatgc gagtgctaaa   420
gatcaagaaa cggaggattt gcttcaagtc ttgaaagact ggtgtcagac ctatcctggt   480
atgtctttct tagtcacagg tcccaaggac ctcgtcgttt cgaaaaatca ggtcgctgta   540
ctgggaaatg gctgtactga attagactgg ataacaggga caggagactt ggttggagcc   600
ttaacagctg tttttctcag ccaaggaaag actggttttg aagcttcttg cttagcagtc   660
tcttatctca atatcgctgc tgagaaaata gttgttcaag gaatgggatt ggaagaattt   720
cgttaccaag tactcaatca gctttcgctc ctaagaagag atgaaaattg gctagatacc   780
atcaaaggag aggtttatga a                                             801

<210>   1360
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydroxyethylthiazole kinase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902680 (e-151)

<400>   1360
Met Gln Glu Phe Thr Asn Pro Phe Pro Ile Gly Ser Ser Ser Leu Ile 
1               5                   10                  15      

His Cys Ile Thr Asn Glu Ile Ser Cys Glu Met Leu Ala Asn Gly Ile 
            20                  25                  30          

Leu Ala Leu Gly Cys Lys Pro Val Met Ala Asp Asp Ser Arg Glu Val 
        35                  40                  45              

Leu Asp Phe Thr Lys Gln Ser Gln Ala Leu Phe Ile Asn Leu Gly His 
    50                  55                  60                  

Leu Ser Ala Glu Lys Glu Lys Ala Ile Arg Met Ala Ala Ser Tyr Ala 
65                  70                  75                  80  

Asn Gln Ser Ser Leu Pro Met Val Val Asp Ala Val Gly Val Thr Thr 
                85                  90                  95      

Ser Ser Ile Arg Lys Ser Leu Val Lys Asp Leu Leu Asp Tyr Arg Pro 
            100                 105                 110         

Thr Val Leu Lys Gly Asn Met Ser Glu Ile Arg Ser Leu Val Gly Leu 
        115                 120                 125             

Lys His His Gly Val Gly Val Asp Ala Ser Ala Lys Asp Gln Glu Thr 
    130                 135                 140                 

Glu Asp Leu Leu Gln Val Leu Lys Asp Trp Cys Gln Thr Tyr Pro Gly 
145                 150                 155                 160 

Met Ser Phe Leu Val Thr Gly Pro Lys Asp Leu Val Val Ser Lys Asn 
                165                 170                 175     

Gln Val Ala Val Leu Gly Asn Gly Cys Thr Glu Leu Asp Trp Ile Thr 
            180                 185                 190         

Gly Thr Gly Asp Leu Val Gly Ala Leu Thr Ala Val Phe Leu Ser Gln 
        195                 200                 205             

Gly Lys Thr Gly Phe Glu Ala Ser Cys Leu Ala Val Ser Tyr Leu Asn 
    210                 215                 220                 

Ile Ala Ala Glu Lys Ile Val Val Gln Gly Met Gly Leu Glu Glu Phe 
225                 230                 235                 240 

Arg Tyr Gln Val Leu Asn Gln Leu Ser Leu Leu Arg Arg Asp Glu Asn 
                245                 250                 255     

Trp Leu Asp Thr Ile Lys Gly Glu Val Tyr Glu 
            260                 265         

<210>   1361
<211>   630
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1361
atgaatagag aagcacttag actatatctg gtaaccaatc gctatcaaga ttccgtggaa   60
agctttcttg caaaagttga gacggcctgc cgttcagggg ttaccatagt ccaattgcga   120
gaaaaaaatc tcacaaccaa tcaatattat caactggcaa aacaagtcaa ggaaataaca   180
gatgcttatc aggtaccctt gataatcgat gatcggttgg atgtttgtct tgcggttgat   240
gcagcaggtc tgcatatcgg agatgatgaa ttaccagttt cggtagctcg caaagtcttg   300
ggtcctgaaa aaatcctcgg tgtcaccgct aaaacggtta aaagagctct ggaagcggag   360
aaatcaggtg cagattactt gggtacagga gccattttcc caaccaccac caaggaaaat   420
gcgcccatta ctctgatatc gaccttgaaa acaatttgcc aaacggttgc cattccagta   480
gttgctattg gaggcttgac ttcggagaat attgatcagc ttatgggcac tggcatagct   540
ggtgtagctg ttgtacgtga tttgatgcaa gcagaagata ttgaggcaaa aacgcaagcc   600
tttttaaaaa agttgcataa cattctttcc                                    630

<210>   1362
<211>   210
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thiamine-phosphate pyrophosphorylase (thiE)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902681 (e-114)

<400>   1362
Met Asn Arg Glu Ala Leu Arg Leu Tyr Leu Val Thr Asn Arg Tyr Gln 
1               5                   10                  15      

Asp Ser Val Glu Ser Phe Leu Ala Lys Val Glu Thr Ala Cys Arg Ser 
            20                  25                  30          

Gly Val Thr Ile Val Gln Leu Arg Glu Lys Asn Leu Thr Thr Asn Gln 
        35                  40                  45              

Tyr Tyr Gln Leu Ala Lys Gln Val Lys Glu Ile Thr Asp Ala Tyr Gln 
    50                  55                  60                  

Val Pro Leu Ile Ile Asp Asp Arg Leu Asp Val Cys Leu Ala Val Asp 
65                  70                  75                  80  

Ala Ala Gly Leu His Ile Gly Asp Asp Glu Leu Pro Val Ser Val Ala 
                85                  90                  95      

Arg Lys Val Leu Gly Pro Glu Lys Ile Leu Gly Val Thr Ala Lys Thr 
            100                 105                 110         

Val Lys Arg Ala Leu Glu Ala Glu Lys Ser Gly Ala Asp Tyr Leu Gly 
        115                 120                 125             

Thr Gly Ala Ile Phe Pro Thr Thr Thr Lys Glu Asn Ala Pro Ile Thr 
    130                 135                 140                 

Leu Ile Ser Thr Leu Lys Thr Ile Cys Gln Thr Val Ala Ile Pro Val 
145                 150                 155                 160 

Val Ala Ile Gly Gly Leu Thr Ser Glu Asn Ile Asp Gln Leu Met Gly 
                165                 170                 175     

Thr Gly Ile Ala Gly Val Ala Val Val Arg Asp Leu Met Gln Ala Glu 
            180                 185                 190         

Asp Ile Glu Ala Lys Thr Gln Ala Phe Leu Lys Lys Leu His Asn Ile 
        195                 200                 205             

Leu Ser 
    210 

<210>   1363
<211>   789
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1363
atgacttatt tacccgttgc tttgaccatt gcagggactg accctagtgg tggtgctggc   60
attatggcag atttaaagtc attccaagcg agagatgtct atggaatggc tgttgtaacc   120
agtcttgtcg ctcaaaatac cagaggtgtt cagctaatcg agcacgtttc tcctcaaatg   180
ttgaaagccc aattggagag tgtcttttct gatattccac ctcaggctgt aaaaactgga   240
atgttggcta ctactgaaat catggaaatc atccaaccct atcttaaaaa actggattgt   300
ccctatgtcc ttgatcctgt tatggttgct acaagtggag atgccttgat tgactcaaat   360
gctagagact atctcaaaac aaacttacta cctctagcaa ctattattac gccaaatctt   420
cctgaagcag aagagattgt tggtttttca atccatgacc ccgaagacat gcagcgtgct   480
ggtcgcctga ttttaaaaga atttggtcct cagtctgtgg ttatcaaagg cggacatctc   540
aaaggtggtg ctaaagattt cctctttacc aagaatgaac aatttgtctg ggaaagccca   600
cgaattcaaa cctgtcacac ccatggtact ggatgtacct ttgctgcagt gattactgct   660
gaactagcca agggcaagag tctttaccag gcagttgata aggccaaggc ctttatcaca   720
aaagctattc aagatgcccc tcaactcggt catggttctg gtccagtcaa ccatacaact   780
tttaaagat                                                           789

<210>   1364
<211>   263
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphomethylpyrimidine kinase (thiD)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902682 (e-150)

<400>   1364
Met Thr Tyr Leu Pro Val Ala Leu Thr Ile Ala Gly Thr Asp Pro Ser 
1               5                   10                  15      

Gly Gly Ala Gly Ile Met Ala Asp Leu Lys Ser Phe Gln Ala Arg Asp 
            20                  25                  30          

Val Tyr Gly Met Ala Val Val Thr Ser Leu Val Ala Gln Asn Thr Arg 
        35                  40                  45              

Gly Val Gln Leu Ile Glu His Val Ser Pro Gln Met Leu Lys Ala Gln 
    50                  55                  60                  

Leu Glu Ser Val Phe Ser Asp Ile Pro Pro Gln Ala Val Lys Thr Gly 
65                  70                  75                  80  

Met Leu Ala Thr Thr Glu Ile Met Glu Ile Ile Gln Pro Tyr Leu Lys 
                85                  90                  95      

Lys Leu Asp Cys Pro Tyr Val Leu Asp Pro Val Met Val Ala Thr Ser 
            100                 105                 110         

Gly Asp Ala Leu Ile Asp Ser Asn Ala Arg Asp Tyr Leu Lys Thr Asn 
        115                 120                 125             

Leu Leu Pro Leu Ala Thr Ile Ile Thr Pro Asn Leu Pro Glu Ala Glu 
    130                 135                 140                 

Glu Ile Val Gly Phe Ser Ile His Asp Pro Glu Asp Met Gln Arg Ala 
145                 150                 155                 160 

Gly Arg Leu Ile Leu Lys Glu Phe Gly Pro Gln Ser Val Val Ile Lys 
                165                 170                 175     

Gly Gly His Leu Lys Gly Gly Ala Lys Asp Phe Leu Phe Thr Lys Asn 
            180                 185                 190         

Glu Gln Phe Val Trp Glu Ser Pro Arg Ile Gln Thr Cys His Thr His 

        195                 200                 205             

Gly Thr Gly Cys Thr Phe Ala Ala Val Ile Thr Ala Glu Leu Ala Lys 
    210                 215                 220                 

Gly Lys Ser Leu Tyr Gln Ala Val Asp Lys Ala Lys Ala Phe Ile Thr 
225                 230                 235                 240 

Lys Ala Ile Gln Asp Ala Pro Gln Leu Gly His Gly Ser Gly Pro Val 
                245                 250                 255     

Asn His Thr Thr Phe Lys Asp 
            260             

<210>   1365
<211>   423
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1365
ttgacaaatg tagattttgg aggtatggta atgcagattt cagatgcaga atggcaggtc   60
atgaagatta tttggatgca gggggagcag accagtacag atttgattag ggttttggca   120
gagcggtttg actggtccaa gtccacggtt cagacacttt tggctcgtct ggttgataaa   180
gagtgtttga ctcggaaaaa agaaggcaag tcctttgttt attcagccct tttaactcta   240
gaccaaagtc gggatttact tgtccaagat atcaaagaca aggtttgttc ccgtaggatt   300
aggaatttgt tggctgactt gattgtagaa tgtgaattta ctcagactga cttggaagac   360
ttggaagctg tgatttcaga gaagaaatca agtgctgtaa cagaagtaag atgtaattgt   420
atg                                                                 423

<210>   1366
<211>   141
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional repressor, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902683 (3.E-71)

<400>   1366
Met Thr Asn Val Asp Phe Gly Gly Met Val Met Gln Ile Ser Asp Ala 
1               5                   10                  15      

Glu Trp Gln Val Met Lys Ile Ile Trp Met Gln Gly Glu Gln Thr Ser 
            20                  25                  30          

Thr Asp Leu Ile Arg Val Leu Ala Glu Arg Phe Asp Trp Ser Lys Ser 
        35                  40                  45              

Thr Val Gln Thr Leu Leu Ala Arg Leu Val Asp Lys Glu Cys Leu Thr 
    50                  55                  60                  

Arg Lys Lys Glu Gly Lys Ser Phe Val Tyr Ser Ala Leu Leu Thr Leu 
65                  70                  75                  80  

Asp Gln Ser Arg Asp Leu Leu Val Gln Asp Ile Lys Asp Lys Val Cys 
                85                  90                  95      

Ser Arg Arg Ile Arg Asn Leu Leu Ala Asp Leu Ile Val Glu Cys Glu 
            100                 105                 110         

Phe Thr Gln Thr Asp Leu Glu Asp Leu Glu Ala Val Ile Ser Glu Lys 
        115                 120                 125             

Lys Ser Ser Ala Val Thr Glu Val Arg Cys Asn Cys Met 
    130                 135                 140     

<210>   1367
<211>   369

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1367
atgttaaata gtattgtaac cattatttgt attgccctta tcgcgtttat cttgttttgg   60
tttttcaaaa agcctgaaaa atctggacaa aaagcccagc aaaaaaacgg ataccaagag   120
attcgagtgg aagtcatggg aggctatact cctgagttga ttgtcctcaa gaaatcagtg   180
ccagcacgca ttgtctttga ccgcaaggat ccttcaccat gtctggatca aattgttttt   240
ccagattttg gtgtacatgc gaacctgcca atgggggaag agtatgtagt ggaaatcacg   300
cctgaacagg ctggagagtt tggctttgct tgtggtatga acatgatgca cggcaagatg   360
attgtagag                                                           369

<210>   1368
<211>   123
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902684 (9.E-69)

<400>   1368
Met Leu Asn Ser Ile Val Thr Ile Ile Cys Ile Ala Leu Ile Ala Phe 
1               5                   10                  15      

Ile Leu Phe Trp Phe Phe Lys Lys Pro Glu Lys Ser Gly Gln Lys Ala 
            20                  25                  30          

Gln Gln Lys Asn Gly Tyr Gln Glu Ile Arg Val Glu Val Met Gly Gly 
        35                  40                  45              

Tyr Thr Pro Glu Leu Ile Val Leu Lys Lys Ser Val Pro Ala Arg Ile 
    50                  55                  60                  

Val Phe Asp Arg Lys Asp Pro Ser Pro Cys Leu Asp Gln Ile Val Phe 
65                  70                  75                  80  

Pro Asp Phe Gly Val His Ala Asn Leu Pro Met Gly Glu Glu Tyr Val 
                85                  90                  95      

Val Glu Ile Thr Pro Glu Gln Ala Gly Glu Phe Gly Phe Ala Cys Gly 
            100                 105                 110         

Met Asn Met Met His Gly Lys Met Ile Val Glu 
        115                 120             

<210>   1369
<211>   2250
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1369
gtggagacta tgacagaaat tgtgaaagca agcttagaaa atggcattca aaaaatccgt   60
atccgagctg aaaaaggcta tcatccagcc catatccagc ttcaaaaggg aattccagct   120
gagattacct ttcatcgtgc tactccttca aactgttata aggaaattct gtttgaagaa   180
gaaggtatct tggaaccaat cggcgtagat gaggagaaag tcattcgttt tacgcctcaa   240
gaattagggc gacatgaatt ttcttgtggc atgaagatgc aaaagggaag ctatacagtc   300
gttgagaaga ctcgaaaatc tctatctctc ctgcaacgtt tttggattac tagtatcttt   360
actgtgcctc ttgtgattct catgattggg atgttgacag gtagcattag tcatcaagtc   420
atgcattggg gaacctttct agcaacaacg cctattatgt tagttgcagg taagccatat   480
atccagagtg cttgggccag ttttaaaaag cacaatgcca acatggatac cttggttgcg   540
ctgggaactc tagtggctta tttctatagc ctagttgctc tctttgctgg tctccctgtt   600
tacttcgaaa gtgctggatt tatcctcttt ttcgttcttt tgggagcagt ttttgaggaa   660
aaaatgagaa aaaatacgtc ccaagctgtg gagaaattac tggacttgca agctaaaacc   720
gcagaagtct tgagtgatga tagttatgtc caagttcctt tggaacaagt caaggtaggc   780
gacctgattc gagtgcgtcc cggtgaaaag attgctgttg atggtgtcgt agtagaaggt   840
gtctctagta ttgacgaatc catggtgaca ggtgagagtc tgcctgtgga caagacagtt   900
ggagatactg tcattggctc aaccatcaat catagtggaa cgcttgtctt tagagcagaa   960
aaagttggct cagagactgt tttggctcag attgtggatt ttgtgaagaa agctcagaca   1020
agtcgtgcgc cgattcagga cttgacggat aagatttcag ggatttttgt cccagtagtt   1080
gtcattttag gaatcatgac cttttgggtt tggttcgtct tgctcaggga tagtgtggtt   1140
gtgcttggag ctagctttgt gtcctctctt ctctacggag tggcggtttt gattatcgcc   1200
tgtccttgtg ccttgggact tgcaacaccg acagccctta tggtggggac aggacgtagt   1260
gccaagatgg gggttctcct caaaaatgga actgtcttac aggaaatcca gaaagttcaa   1320
acccttgtct ttgataagac cgggactttg acggaaggga aacctgtggt aacagatgtc   1380
atcggcgacg aagtagaagt gtttgggttg gcagcctcct tggaagatgc ttctcaacac   1440
ccactggctg aggctatcgt taagcgagcg agtgaagctg gacttgagtt tcaaactgtt   1500
gaaaattttc agtccttgca cgggaaaggt gtttcagggc gaatcaatgg aaaacaagtt   1560
ttacttggaa atgctaaaat gctggatggc atggatattt ctaatactta tcaagataaa   1620
ctagaagaac tagaaaaaga agctaagaca gttgtgttct tagctgttga caatgaaatc   1680
aaaggcttgc ttgctttgca agatattcct aaggaaaatg ctaagctagc catcagtcag   1740
ctaaaaaaac gtggtctccg aacagtcatg ctgacaggag acaatgctgg tgtggcgcgt   1800
gctattgcag atcaaatcgg aattgaagag gtcattgcag gcgtcttgcc agaagaaaaa   1860
gcccatgaaa tccataaact gcaacagtca gggaaagtag cctttgttgg ggacggtatc   1920
aatgacgctc ctgcccttag tgtagcagat gtggggattg ctatgggagc tggaacagat   1980
atcgccatcg agtcagcaga tttggtgttg acaaccaata atcttttagg agtggttcgt   2040
gcctttgata tgagtaagaa aacctttcat cgaattctac tcaatctttt ctgggctttt   2100
atctacaatg ttgtcggaat tccgattgca gcaggagtct tttcaggtgt tggactggct   2160
ctcaacccag aattggcagg tctagccatg gcctttagtt ctgtatctgt tctgaccagt   2220
tcccttctgt taaattttag taaaatagac                                    2250

<210>   1370
<211>   750
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cation-transporting ATPase, E1-E2 family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902685 (0.E+01)

<400>   1370
Met Glu Thr Met Thr Glu Ile Val Lys Ala Ser Leu Glu Asn Gly Ile 
1               5                   10                  15      

Gln Lys Ile Arg Ile Arg Ala Glu Lys Gly Tyr His Pro Ala His Ile 
            20                  25                  30          

Gln Leu Gln Lys Gly Ile Pro Ala Glu Ile Thr Phe His Arg Ala Thr 
        35                  40                  45              

Pro Ser Asn Cys Tyr Lys Glu Ile Leu Phe Glu Glu Glu Gly Ile Leu 
    50                  55                  60                  

Glu Pro Ile Gly Val Asp Glu Glu Lys Val Ile Arg Phe Thr Pro Gln 
65                  70                  75                  80  

Glu Leu Gly Arg His Glu Phe Ser Cys Gly Met Lys Met Gln Lys Gly 
                85                  90                  95      

Ser Tyr Thr Val Val Glu Lys Thr Arg Lys Ser Leu Ser Leu Leu Gln 
            100                 105                 110         

Arg Phe Trp Ile Thr Ser Ile Phe Thr Val Pro Leu Val Ile Leu Met 
        115                 120                 125             

Ile Gly Met Leu Thr Gly Ser Ile Ser His Gln Val Met His Trp Gly 
    130                 135                 140                 

Thr Phe Leu Ala Thr Thr Pro Ile Met Leu Val Ala Gly Lys Pro Tyr 
145                 150                 155                 160 

Ile Gln Ser Ala Trp Ala Ser Phe Lys Lys His Asn Ala Asn Met Asp 
                165                 170                 175     

Thr Leu Val Ala Leu Gly Thr Leu Val Ala Tyr Phe Tyr Ser Leu Val 
            180                 185                 190         

Ala Leu Phe Ala Gly Leu Pro Val Tyr Phe Glu Ser Ala Gly Phe Ile 
        195                 200                 205             

Leu Phe Phe Val Leu Leu Gly Ala Val Phe Glu Glu Lys Met Arg Lys 
    210                 215                 220                 

Asn Thr Ser Gln Ala Val Glu Lys Leu Leu Asp Leu Gln Ala Lys Thr 
225                 230                 235                 240 

Ala Glu Val Leu Ser Asp Asp Ser Tyr Val Gln Val Pro Leu Glu Gln 
                245                 250                 255     

Val Lys Val Gly Asp Leu Ile Arg Val Arg Pro Gly Glu Lys Ile Ala 
            260                 265                 270         

Val Asp Gly Val Val Val Glu Gly Val Ser Ser Ile Asp Glu Ser Met 
        275                 280                 285             

Val Thr Gly Glu Ser Leu Pro Val Asp Lys Thr Val Gly Asp Thr Val 
    290                 295                 300                 

Ile Gly Ser Thr Ile Asn His Ser Gly Thr Leu Val Phe Arg Ala Glu 
305                 310                 315                 320 

Lys Val Gly Ser Glu Thr Val Leu Ala Gln Ile Val Asp Phe Val Lys 
                325                 330                 335     

Lys Ala Gln Thr Ser Arg Ala Pro Ile Gln Asp Leu Thr Asp Lys Ile 
            340                 345                 350         

Ser Gly Ile Phe Val Pro Val Val Val Ile Leu Gly Ile Met Thr Phe 
        355                 360                 365             

Trp Val Trp Phe Val Leu Leu Arg Asp Ser Val Val Val Leu Gly Ala 
    370                 375                 380                 

Ser Phe Val Ser Ser Leu Leu Tyr Gly Val Ala Val Leu Ile Ile Ala 
385                 390                 395                 400 

Cys Pro Cys Ala Leu Gly Leu Ala Thr Pro Thr Ala Leu Met Val Gly 
                405                 410                 415     

Thr Gly Arg Ser Ala Lys Met Gly Val Leu Leu Lys Asn Gly Thr Val 
            420                 425                 430         

Leu Gln Glu Ile Gln Lys Val Gln Thr Leu Val Phe Asp Lys Thr Gly 
        435                 440                 445             

Thr Leu Thr Glu Gly Lys Pro Val Val Thr Asp Val Ile Gly Asp Glu 
    450                 455                 460                 

Val Glu Val Phe Gly Leu Ala Ala Ser Leu Glu Asp Ala Ser Gln His 
465                 470                 475                 480 

Pro Leu Ala Glu Ala Ile Val Lys Arg Ala Ser Glu Ala Gly Leu Glu 
                485                 490                 495     

Phe Gln Thr Val Glu Asn Phe Gln Ser Leu His Gly Lys Gly Val Ser 
            500                 505                 510         

Gly Arg Ile Asn Gly Lys Gln Val Leu Leu Gly Asn Ala Lys Met Leu 
        515                 520                 525             

Asp Gly Met Asp Ile Ser Asn Thr Tyr Gln Asp Lys Leu Glu Glu Leu 
    530                 535                 540                 

Glu Lys Glu Ala Lys Thr Val Val Phe Leu Ala Val Asp Asn Glu Ile 
545                 550                 555                 560 

Lys Gly Leu Leu Ala Leu Gln Asp Ile Pro Lys Glu Asn Ala Lys Leu 
                565                 570                 575     

Ala Ile Ser Gln Leu Lys Lys Arg Gly Leu Arg Thr Val Met Leu Thr 
            580                 585                 590         

Gly Asp Asn Ala Gly Val Ala Arg Ala Ile Ala Asp Gln Ile Gly Ile 
        595                 600                 605             

Glu Glu Val Ile Ala Gly Val Leu Pro Glu Glu Lys Ala His Glu Ile 
    610                 615                 620                 

His Lys Leu Gln Gln Ser Gly Lys Val Ala Phe Val Gly Asp Gly Ile 
625                 630                 635                 640 

Asn Asp Ala Pro Ala Leu Ser Val Ala Asp Val Gly Ile Ala Met Gly 
                645                 650                 655     

Ala Gly Thr Asp Ile Ala Ile Glu Ser Ala Asp Leu Val Leu Thr Thr 
            660                 665                 670         

Asn Asn Leu Leu Gly Val Val Arg Ala Phe Asp Met Ser Lys Lys Thr 
        675                 680                 685             

Phe His Arg Ile Leu Leu Asn Leu Phe Trp Ala Phe Ile Tyr Asn Val 
    690                 695                 700                 

Val Gly Ile Pro Ile Ala Ala Gly Val Phe Ser Gly Val Gly Leu Ala 
705                 710                 715                 720 

Leu Asn Pro Glu Leu Ala Gly Leu Ala Met Ala Phe Ser Ser Val Ser 
                725                 730                 735     

Val Leu Thr Ser Ser Leu Leu Leu Asn Phe Ser Lys Ile Asp 
            740                 745                 750 

<210>   1371
<211>   1773
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1371
atgactcaag ggaaaattac tgcatctgca gcaatgctta acgtattgaa aacatggggc   60
gtagatacaa tctacggtat cccatcagga acactcagct cattgatgga cgctttggct   120
gaagacaaag atatccgttt cttacaagtt cgccacgaag agacaggtgc tcttgcagcg   180
gttatgcaag ctaaattcgg cggctcaatc ggggttgcag ttggttcagg tggtccaggt   240
gcgactcact tgattaacgg tgtttacgat gcagctatgg ataacactcc attcctagcg   300
atccttggat cacgtccagt taacgaattg aacatggatg ctttccaaga gcttaaccaa   360
aacccaatgt acaacggtat cgctgtttac aacaaacgtg tagcttacgc tgagcaattg   420
ccaaaagtaa ttgacgaagc ctgccgtgct gcagtttcta aaaaaggtcc agctgttgtt   480
gaaattccag taaacttcgg tttccaagaa atcgatgaaa actcatacta cggttcaggt   540
tcatacgaac gctcattcat cgctcctgct ttgaacgaag ttgaaatcga caaagctgtt   600
gaaatcttga acaatgctga acgcccagtt atctatgctg gatttggtgg tgttaaagct   660
ggtgaagtga ttactgaatt gtcacgtaaa atcaaagcac caatcatcac aactggtaaa   720
aactttgaag ctttcgaatg gaactatgaa ggtttgacag gttctgctta ccgtgttggt   780
tggaaaccag ccaacgaagt ggtctttgaa gcagacacag ttcttttcct tggttcaaac   840
ttcccatttg ctgaagttta cgaagcattc aagaacactg aaaaattcat ccaagtcgat   900
atcgaccctt acaaacttgg taaacgtcat gcccttgacg cttcaatcct tggtgatgct   960
ggtcaagcag ctaaagctat ccttgacaaa gtaaacccag ttgaatcaac tccatggtgg   1020
cgtgcaaacg ttaagaacaa ccaaaactgg cgtgattaca tgaacaaact cgaaggtaaa   1080
actgagggtg aattgcaatt gtatcaagtt tacaatgcaa tcaacaaaca tgctgatcaa   1140
gacgctatct actcaatcga cgtaggtaac actactcaaa catctactcg tcaccttcac   1200
atgacaccta agaacatgtg gcgtacatct ccactctttg cgacaatggg tattgccctt   1260
cctggtggta tcgctgctaa gaaagacaat ccagatcgcc aagtatggaa catcatgggt   1320
gacggagcat tcaacatgtg ctacccagac gttatcacaa acgttcaata cgaccttcca   1380
gttatcaacc ttgtcttctc aaatgctgag tacggcttca tcaagaacaa atacgaagat   1440
acaaacaaac acttgtttgg tgtagacttc acaaacgctg actacgctaa aattgcggaa   1500
gctcaaggag ctgttggatt cacagttgac cgtatcgaag acatcgatgc agttgttgca   1560
gaagctgtta aattgaacaa agaaggtaaa actgttgtca tcgatgctcg catcactcaa   1620
caccgtccac ttccagtaga agtacttgaa ttggatccaa aacttcactc agaagaagct   1680
atcaaagcct tcaaggaaaa atacgaagca gaagaactcg taccattccg tctcttcttg   1740
gaagaagaag gattgcaatc acgcgcaatt aaa                                1773

<210>   1372
<211>   591
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyruvate oxidase (spxB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902686 (0.E+01)

<400>   1372
Met Thr Gln Gly Lys Ile Thr Ala Ser Ala Ala Met Leu Asn Val Leu 
1               5                   10                  15      

Lys Thr Trp Gly Val Asp Thr Ile Tyr Gly Ile Pro Ser Gly Thr Leu 
            20                  25                  30          

Ser Ser Leu Met Asp Ala Leu Ala Glu Asp Lys Asp Ile Arg Phe Leu 
        35                  40                  45              

Gln Val Arg His Glu Glu Thr Gly Ala Leu Ala Ala Val Met Gln Ala 
    50                  55                  60                  

Lys Phe Gly Gly Ser Ile Gly Val Ala Val Gly Ser Gly Gly Pro Gly 
65                  70                  75                  80  

Ala Thr His Leu Ile Asn Gly Val Tyr Asp Ala Ala Met Asp Asn Thr 
                85                  90                  95      

Pro Phe Leu Ala Ile Leu Gly Ser Arg Pro Val Asn Glu Leu Asn Met 
            100                 105                 110         

Asp Ala Phe Gln Glu Leu Asn Gln Asn Pro Met Tyr Asn Gly Ile Ala 
        115                 120                 125             

Val Tyr Asn Lys Arg Val Ala Tyr Ala Glu Gln Leu Pro Lys Val Ile 
    130                 135                 140                 

Asp Glu Ala Cys Arg Ala Ala Val Ser Lys Lys Gly Pro Ala Val Val 
145                 150                 155                 160 

Glu Ile Pro Val Asn Phe Gly Phe Gln Glu Ile Asp Glu Asn Ser Tyr 
                165                 170                 175     

Tyr Gly Ser Gly Ser Tyr Glu Arg Ser Phe Ile Ala Pro Ala Leu Asn 
            180                 185                 190         

Glu Val Glu Ile Asp Lys Ala Val Glu Ile Leu Asn Asn Ala Glu Arg 
        195                 200                 205             

Pro Val Ile Tyr Ala Gly Phe Gly Gly Val Lys Ala Gly Glu Val Ile 
    210                 215                 220                 

Thr Glu Leu Ser Arg Lys Ile Lys Ala Pro Ile Ile Thr Thr Gly Lys 
225                 230                 235                 240 

Asn Phe Glu Ala Phe Glu Trp Asn Tyr Glu Gly Leu Thr Gly Ser Ala 
                245                 250                 255     

Tyr Arg Val Gly Trp Lys Pro Ala Asn Glu Val Val Phe Glu Ala Asp 
            260                 265                 270         

Thr Val Leu Phe Leu Gly Ser Asn Phe Pro Phe Ala Glu Val Tyr Glu 
        275                 280                 285             

Ala Phe Lys Asn Thr Glu Lys Phe Ile Gln Val Asp Ile Asp Pro Tyr 
    290                 295                 300                 

Lys Leu Gly Lys Arg His Ala Leu Asp Ala Ser Ile Leu Gly Asp Ala 
305                 310                 315                 320 

Gly Gln Ala Ala Lys Ala Ile Leu Asp Lys Val Asn Pro Val Glu Ser 
                325                 330                 335     

Thr Pro Trp Trp Arg Ala Asn Val Lys Asn Asn Gln Asn Trp Arg Asp 
            340                 345                 350         

Tyr Met Asn Lys Leu Glu Gly Lys Thr Glu Gly Glu Leu Gln Leu Tyr 
        355                 360                 365             

Gln Val Tyr Asn Ala Ile Asn Lys His Ala Asp Gln Asp Ala Ile Tyr 
    370                 375                 380                 

Ser Ile Asp Val Gly Asn Thr Thr Gln Thr Ser Thr Arg His Leu His 
385                 390                 395                 400 

Met Thr Pro Lys Asn Met Trp Arg Thr Ser Pro Leu Phe Ala Thr Met 
                405                 410                 415     

Gly Ile Ala Leu Pro Gly Gly Ile Ala Ala Lys Lys Asp Asn Pro Asp 
            420                 425                 430         

Arg Gln Val Trp Asn Ile Met Gly Asp Gly Ala Phe Asn Met Cys Tyr 
        435                 440                 445             

Pro Asp Val Ile Thr Asn Val Gln Tyr Asp Leu Pro Val Ile Asn Leu 
    450                 455                 460                 

Val Phe Ser Asn Ala Glu Tyr Gly Phe Ile Lys Asn Lys Tyr Glu Asp 
465                 470                 475                 480 

Thr Asn Lys His Leu Phe Gly Val Asp Phe Thr Asn Ala Asp Tyr Ala 
                485                 490                 495     

Lys Ile Ala Glu Ala Gln Gly Ala Val Gly Phe Thr Val Asp Arg Ile 
            500                 505                 510         

Glu Asp Ile Asp Ala Val Val Ala Glu Ala Val Lys Leu Asn Lys Glu 
        515                 520                 525             

Gly Lys Thr Val Val Ile Asp Ala Arg Ile Thr Gln His Arg Pro Leu 
    530                 535                 540                 

Pro Val Glu Val Leu Glu Leu Asp Pro Lys Leu His Ser Glu Glu Ala 
545                 550                 555                 560 

Ile Lys Ala Phe Lys Glu Lys Tyr Glu Ala Glu Glu Leu Val Pro Phe 
                565                 570                 575     

Arg Leu Phe Leu Glu Glu Glu Gly Leu Gln Ser Arg Ala Ile Lys 
            580                 585                 590     

<210>   1373
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1373
atgaatttaa atcaattaga tattatcgtt tcaaatgttc cccaagtctg tgctgacttg   60
gagcatatct tggataaaaa ggcagattat gctaatgatg gttttgctca gtttacgatt   120
ggtagtcact gccttatgtt gtcacaaaat catttggttc ctttggaaaa ctttcagtca   180
ggaatcatta ttcatatcga ggttgaggat gtagaccaga actacaaacg gttgaacgag   240
cttggtataa aggttttaca cggaccaact gtaaccgatt ggggaacaga gtccttatta   300
gttcaaggac ctgctggtct agtgcttgat ttttatcgta tgaaa                   345

<210>   1374
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902687 (8.E-64)

<400>   1374
Met Asn Leu Asn Gln Leu Asp Ile Ile Val Ser Asn Val Pro Gln Val 
1               5                   10                  15      

Cys Ala Asp Leu Glu His Ile Leu Asp Lys Lys Ala Asp Tyr Ala Asn 
            20                  25                  30          

Asp Gly Phe Ala Gln Phe Thr Ile Gly Ser His Cys Leu Met Leu Ser 
        35                  40                  45              

Gln Asn His Leu Val Pro Leu Glu Asn Phe Gln Ser Gly Ile Ile Ile 
    50                  55                  60                  

His Ile Glu Val Glu Asp Val Asp Gln Asn Tyr Lys Arg Leu Asn Glu 
65                  70                  75                  80  

Leu Gly Ile Lys Val Leu His Gly Pro Thr Val Thr Asp Trp Gly Thr 
                85                  90                  95      

Glu Ser Leu Leu Val Gln Gly Pro Ala Gly Leu Val Leu Asp Phe Tyr 
            100                 105                 110         

Arg Met Lys 
        115 

<210>   1375
<211>   499
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1375
ttgatgtacc aagctgaagc tggtttcggt agaatcagta aactgggatc ttgttgggct   60
ccaataggag taggtccaca tatccatagt cactatatac gagaatttcg ctattgttat   120
ggagctgttg atgcctatac aggcgaatca tttttcttaa tagctggtag atgtaatact   180
gagtggatga acgccttttt agaagagctt tcacaagctt atccttttac tcgttatgga   240
caatgctata tggcataaat caagtacctt aaagattccg actaatattg gttttgcatt   300
tattcctcca tacacaccag agatgaaccc cattgaacaa gtgtggaaag agattcgtaa   360
acgtggattt aagaataaag cctttcgaat tttggaagat gtcatgaatc aactccaaga   420
tgtcatacaa ggattggaga aggaggtgat aaagtccatc gttaatcgga gatggactag   480

aatgcttttt gaaagcaga                                                499


<210>   1376
<400>   1376
000

<210>   1377
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1377
atgacagttg aggaagagaa agcctttctt gcccgccatt tgaaggctac agaggcagga   60
gaatttgtta caattgatgc cttatttcag gcttataaaa aggagttagg tcgttcctac   120
acacgtgatg ccttctatca actgttgaag cgccatggtt ggcgaaatat tacgccacgt   180
ccagaacatc ctaagaaagc agacgctcaa accattgttg cgtctaaaaa taaaatctca   240
atccaagaag gcaagaaagc gttt                                          264

<210>   1378
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Degenerate transposase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903223 (2.E-45)

<400>   1378
Met Thr Val Glu Glu Glu Lys Ala Phe Leu Ala Arg His Leu Lys Ala 
1               5                   10                  15      

Thr Glu Ala Gly Glu Phe Val Thr Ile Asp Ala Leu Phe Gln Ala Tyr 
            20                  25                  30          

Lys Lys Glu Leu Gly Arg Ser Tyr Thr Arg Asp Ala Phe Tyr Gln Leu 
        35                  40                  45              

Leu Lys Arg His Gly Trp Arg Asn Ile Thr Pro Arg Pro Glu His Pro 
    50                  55                  60                  

Lys Lys Ala Asp Ala Gln Thr Ile Val Ala Ser Lys Asn Lys Ile Ser 
65                  70                  75                  80  

Ile Gln Glu Gly Lys Lys Ala Phe 
                85              

<210>   1379
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1379
atgaaatcaa ctaaagaaga aatccaaacc atcaaaacac ttttaaaaga ctctcgtaca   60
gctaaatatc ataaacgcct tcaaatcgtt cta                                93

<210>   1380
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1380
Met Lys Ser Thr Lys Glu Glu Ile Gln Thr Ile Lys Thr Leu Leu Lys 
1               5                   10                  15      

Asp Ser Arg Thr Ala Lys Tyr His Lys Arg Leu Gln Ile Val Leu 
            20                  25                  30      

<210>   1381
<211>   294
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1381
atggatacac cggatgagaa tggttatgta gcagatgact atcggattac ttacttagag   60
gcccacatca aggccatgcg agatgccatt taccaagacg gggttgactt gcttggttat   120
acgacttggg gctgtatcga tccggtttca gctggcacag gggaaatgaa taagcgctat   180
ggctttatct atgtagatcg agataatgta ggaaacggag ctctcaaacg tagcaagaag   240
aagtccttct attggtacaa ggatgtcatt tatagcaatg gtgcaagcat cggg         294

<210>   1382
<211>   98
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   6-phospho-beta-glucosidase, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902690 (1.E-52)

<400>   1382
Met Asp Thr Pro Asp Glu Asn Gly Tyr Val Ala Asp Asp Tyr Arg Ile 
1               5                   10                  15      

Thr Tyr Leu Glu Ala His Ile Lys Ala Met Arg Asp Ala Ile Tyr Gln 
            20                  25                  30          

Asp Gly Val Asp Leu Leu Gly Tyr Thr Thr Trp Gly Cys Ile Asp Pro 
        35                  40                  45              

Val Ser Ala Gly Thr Gly Glu Met Asn Lys Arg Tyr Gly Phe Ile Tyr 
    50                  55                  60                  

Val Asp Arg Asp Asn Val Gly Asn Gly Ala Leu Lys Arg Ser Lys Lys 
65                  70                  75                  80  

Lys Ser Phe Tyr Trp Tyr Lys Asp Val Ile Tyr Ser Asn Gly Ala Ser 
                85                  90                  95      

Ile Gly 
        

<210>   1383
<211>   942
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1383
atgtcagaac cattattttt acaatcagtt atgcaagaaa aaatctgggg tggagccaag   60
ctacgtgatg agtttggcta cgacatccca agtgaaaaaa tcggagaata ttgggccatc   120
tcagcccatc caaatggagt ctctaaagtt gccaatggtc gttacgaggg aacagatctt   180
gctactttgt atgcggaaca ccgtgaatta tttggcaatc gtccagaacc tgtatttcca   240
cttttgacca agatcctcga tgccaacgac tggctcagtg tccaagttca cccagacgat   300
gcttatggac tcgagcatga aggcgaactc ggaaaaacag aatgctggta cattatcgca   360
gcggatgaag gttcagagat tatctacggt cacaatgcca agtcaaaaga agaactccgc   420
cagcaaatcg aggacaagaa ctgggatgac ttgttgacca aagtccctgt taaggctgga   480
gatttcttct atgtaccaag cgggactatg cacgctatcg gggcgggtat cttaatcctt   540
gaaacccagc agtctagcga taccacctat cgcgtctatg actttgaccg caaggatgac   600
aaaggcaact tgcgtgaact tcatcttgaa aaatccatcg atgtcttgaa cattggtgag   660
ccagcaaata gccgtcctgt aactgttaaa gcagatgatt tgcgttccac tctccttgta   720
tctaatgatt tcttcgcagt ttacaagtgg gaaattactg gaaaagttga ctttgaaaag   780
acagctgact acagcttatt gagtgtcttg gctggtcaag gtcagctaac tgttgacggg   840
aaaaattatc caattcaaaa aggcagccac tttatcctac caagtgatgt tgaagcttgg   900
actctggaag ggcaaggttt ggaattgatt gttagccatc ca                      942

<210>   1384
<211>   314
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   mannose-6-phosphate isomerase (manA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902691 (0.E+01)

<400>   1384
Met Ser Glu Pro Leu Phe Leu Gln Ser Val Met Gln Glu Lys Ile Trp 
1               5                   10                  15      

Gly Gly Ala Lys Leu Arg Asp Glu Phe Gly Tyr Asp Ile Pro Ser Glu 
            20                  25                  30          

Lys Ile Gly Glu Tyr Trp Ala Ile Ser Ala His Pro Asn Gly Val Ser 
        35                  40                  45              

Lys Val Ala Asn Gly Arg Tyr Glu Gly Thr Asp Leu Ala Thr Leu Tyr 
    50                  55                  60                  

Ala Glu His Arg Glu Leu Phe Gly Asn Arg Pro Glu Pro Val Phe Pro 
65                  70                  75                  80  

Leu Leu Thr Lys Ile Leu Asp Ala Asn Asp Trp Leu Ser Val Gln Val 
                85                  90                  95      

His Pro Asp Asp Ala Tyr Gly Leu Glu His Glu Gly Glu Leu Gly Lys 
            100                 105                 110         

Thr Glu Cys Trp Tyr Ile Ile Ala Ala Asp Glu Gly Ser Glu Ile Ile 
        115                 120                 125             

Tyr Gly His Asn Ala Lys Ser Lys Glu Glu Leu Arg Gln Gln Ile Glu 
    130                 135                 140                 

Asp Lys Asn Trp Asp Asp Leu Leu Thr Lys Val Pro Val Lys Ala Gly 
145                 150                 155                 160 

Asp Phe Phe Tyr Val Pro Ser Gly Thr Met His Ala Ile Gly Ala Gly 
                165                 170                 175     

Ile Leu Ile Leu Glu Thr Gln Gln Ser Ser Asp Thr Thr Tyr Arg Val 
            180                 185                 190         

Tyr Asp Phe Asp Arg Lys Asp Asp Lys Gly Asn Leu Arg Glu Leu His 
        195                 200                 205             

Leu Glu Lys Ser Ile Asp Val Leu Asn Ile Gly Glu Pro Ala Asn Ser 
    210                 215                 220                 

Arg Pro Val Thr Val Lys Ala Asp Asp Leu Arg Ser Thr Leu Leu Val 
225                 230                 235                 240 

Ser Asn Asp Phe Phe Ala Val Tyr Lys Trp Glu Ile Thr Gly Lys Val 
                245                 250                 255     

Asp Phe Glu Lys Thr Ala Asp Tyr Ser Leu Leu Ser Val Leu Ala Gly 
            260                 265                 270         

Gln Gly Gln Leu Thr Val Asp Gly Lys Asn Tyr Pro Ile Gln Lys Gly 
        275                 280                 285             

Ser His Phe Ile Leu Pro Ser Asp Val Glu Ala Trp Thr Leu Glu Gly 

    290                 295                 300                 

Gln Gly Leu Glu Leu Ile Val Ser His Pro 
305                 310                 

<210>   1385
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1385
atggaaacaa ggactgttcc aagtctggct cttccttctt cgtttcttcg tttcgtcatt   60
ccaatcatca tcattgtggt cttcattgcc caatttatg                          99

<210>   1386
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1386
Met Glu Thr Arg Thr Val Pro Ser Leu Ala Leu Pro Ser Ser Phe Leu 
1               5                   10                  15      

Arg Phe Val Ile Pro Ile Ile Ile Ile Val Val Phe Ile Ala Gln Phe 
            20                  25                  30          

Met 
    

<210>   1387
<211>   201
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1387
ttgttagcca tccataaaaa gaaagggcct gagttcacta ctcaagtcct ttttgattac   60
ataaattggg caatgaagac cacaatgatg atgattggaa tgacgaaacg aagaaacgaa   120
gaaggaagag ccagacttgg aacagtcctt gtttccatgc tctttcatcg agatggagtt   180
cctccattgc aagagccttt t                                             201

<210>   1388
<211>   67
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1388
Met Leu Ala Ile His Lys Lys Lys Gly Pro Glu Phe Thr Thr Gln Val 
1               5                   10                  15      

Leu Phe Asp Tyr Ile Asn Trp Ala Met Lys Thr Thr Met Met Met Ile 
            20                  25                  30          

Gly Met Thr Lys Arg Arg Asn Glu Glu Gly Arg Ala Arg Leu Gly Thr 
        35                  40                  45              

Val Leu Val Ser Met Leu Phe His Arg Asp Gly Val Pro Pro Leu Gln 
    50                  55                  60                  

Glu Pro Phe 
65          

<210>   1389
<211>   1269
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1389
atgactgctg ctaatggcgg tggaggcttt ttactaatct ttctcatttc cactatttta   60
atcggtttcc ctctcctgct ggctgagttt gcccttggcc gtagtgctgg cgtttccgct   120
atcaaaacct ttggaaaact gggcaagaat aacaagtaca actttatcgg ttggattggc   180
gcctttgccc tctttatcct cttatctttt tacagtgtta tcggaggatg gattctagtc   240
tatctaggta ttgagtttgg gaaattgttc caacttggtg gaacgggtga ttatgctcag   300
ttatttactt caatcatttc aaatccagcc attgccctag gagctcaagc ggcctttatc   360
ctattgaata tcttcattgt atcacgtggg gttcaaaaag ggattgaaag agcttcgaaa   420
gtcatgatgc ccctgctctt tatcgtcttt gtttttatca tcggtcgctc tctcagtttg   480
ccaaatgcca tggaaggggt tctttacttc ctcaaaccag acttttcaaa actgactagc   540
actggtctcc tctatgctct gggacaatct ttctttgccc tctcactagg ggttacagtc   600
atgttgacct atgcttctta cttagacaag aaaaccaatc tagtccagtc aggaatctcc   660
atcgtagcca tgaatatctc gatatccatc atggcaggtc tagccatttt ccaagctcga   720
tcccccttca atatccagtc tgaaggggga cccagcctgc tctttatcgt cttgcctcaa   780
ctctttgaca agatgccttt tggaaccatt ttctacgtcc tcttcctctt gctcttcctt   840
tttgcgacag tcactttttc tgtcgtgatg ctggaaatca atgtagacaa tatcaccaac   900
caggataaca gcaaacgtgc caaatggagt gttattttag gaattttgac ctttgtcttt   960
ggcattcctt cagccctatc ttacggtgtc atggcggatg ttcacatttt tggtaagacc   1020
ttctttgacg ctatggactt cttggtttcc aatctcctca tgccatttgg agctctctac   1080
ctttcacttt ttacaggcta tatctttaaa aaggctcttg caatggagga actccatctc   1140
gatgaaagag catggaaaca aggactgttc caagtctggc tcttccttct tcgtttcttc   1200
gtttcgtcat tccaatcatc atcattgtgg tcttcattgc ccaatttatg taatcaaaaa   1260
ggacttgag                                                           1269

<210>   1390
<211>   423
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sodium-dependent transporter, FRAMESHIFT
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902692 (0.E+01)

<400>   1390
Met Thr Ala Ala Asn Gly Gly Gly Gly Phe Leu Leu Ile Phe Leu Ile 
1               5                   10                  15      

Ser Thr Ile Leu Ile Gly Phe Pro Leu Leu Leu Ala Glu Phe Ala Leu 
            20                  25                  30          

Gly Arg Ser Ala Gly Val Ser Ala Ile Lys Thr Phe Gly Lys Leu Gly 
        35                  40                  45              

Lys Asn Asn Lys Tyr Asn Phe Ile Gly Trp Ile Gly Ala Phe Ala Leu 
    50                  55                  60                  

Phe Ile Leu Leu Ser Phe Tyr Ser Val Ile Gly Gly Trp Ile Leu Val 
65                  70                  75                  80  

Tyr Leu Gly Ile Glu Phe Gly Lys Leu Phe Gln Leu Gly Gly Thr Gly 
                85                  90                  95      

Asp Tyr Ala Gln Leu Phe Thr Ser Ile Ile Ser Asn Pro Ala Ile Ala 
            100                 105                 110         

Leu Gly Ala Gln Ala Ala Phe Ile Leu Leu Asn Ile Phe Ile Val Ser 
        115                 120                 125             

Arg Gly Val Gln Lys Gly Ile Glu Arg Ala Ser Lys Val Met Met Pro 
    130                 135                 140                 

Leu Leu Phe Ile Val Phe Val Phe Ile Ile Gly Arg Ser Leu Ser Leu 
145                 150                 155                 160 

Pro Asn Ala Met Glu Gly Val Leu Tyr Phe Leu Lys Pro Asp Phe Ser 
                165                 170                 175     

Lys Leu Thr Ser Thr Gly Leu Leu Tyr Ala Leu Gly Gln Ser Phe Phe 
            180                 185                 190         

Ala Leu Ser Leu Gly Val Thr Val Met Leu Thr Tyr Ala Ser Tyr Leu 
        195                 200                 205             

Asp Lys Lys Thr Asn Leu Val Gln Ser Gly Ile Ser Ile Val Ala Met 
    210                 215                 220                 

Asn Ile Ser Ile Ser Ile Met Ala Gly Leu Ala Ile Phe Gln Ala Arg 
225                 230                 235                 240 

Ser Pro Phe Asn Ile Gln Ser Glu Gly Gly Pro Ser Leu Leu Phe Ile 
                245                 250                 255     

Val Leu Pro Gln Leu Phe Asp Lys Met Pro Phe Gly Thr Ile Phe Tyr 
            260                 265                 270         

Val Leu Phe Leu Leu Leu Phe Leu Phe Ala Thr Val Thr Phe Ser Val 
        275                 280                 285             

Val Met Leu Glu Ile Asn Val Asp Asn Ile Thr Asn Gln Asp Asn Ser 
    290                 295                 300                 

Lys Arg Ala Lys Trp Ser Val Ile Leu Gly Ile Leu Thr Phe Val Phe 
305                 310                 315                 320 

Gly Ile Pro Ser Ala Leu Ser Tyr Gly Val Met Ala Asp Val His Ile 
                325                 330                 335     

Phe Gly Lys Thr Phe Phe Asp Ala Met Asp Phe Leu Val Ser Asn Leu 
            340                 345                 350         

Leu Met Pro Phe Gly Ala Leu Tyr Leu Ser Leu Phe Thr Gly Tyr Ile 
        355                 360                 365             

Phe Lys Lys Ala Leu Ala Met Glu Glu Leu His Leu Asp Glu Arg Ala 
    370                 375                 380                 

Trp Lys Gln Gly Leu Phe Gln Val Trp Leu Phe Leu Leu Arg Phe Phe 
385                 390                 395                 400 

Val Ser Ser Phe Gln Ser Ser Ser Leu Trp Ser Ser Leu Pro Asn Leu 
                405                 410                 415     

Cys Asn Gln Lys Gly Leu Glu 
            420             

<210>   1391
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1391
ttgaaaatga ttttcttgac agaccttaga aaacatgata ggatagtcaa gtctatcaat   60
caaacagaag gctatttgac aactcaagta gctttttctt attttgaaaa aggagatcag   120
agtttaacta tgtcagaaaa atcacaatgg gggtcgaaac ttggttttat tctagcatct   180
gctggctggc catcgggctt ggttccgttt ggaagtttcc ctaca                   225

<210>   1392
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein (Sodium-dependent)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902692 (2.E-31)

<400>   1392
Met Lys Met Ile Phe Leu Thr Asp Leu Arg Lys His Asp Arg Ile Val 
1               5                   10                  15      

Lys Ser Ile Asn Gln Thr Glu Gly Tyr Leu Thr Thr Gln Val Ala Phe 
            20                  25                  30          

Ser Tyr Phe Glu Lys Gly Asp Gln Ser Leu Thr Met Ser Glu Lys Ser 
        35                  40                  45              


Gln Trp Gly Ser Lys Leu Gly Phe Ile Leu Ala Ser Ala Gly Trp Pro 
    50                  55                  60                  

Ser Gly Leu Val Pro Phe Gly Ser Phe Pro Thr 
65                  70                  75  

<210>   1393
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1393
atgtaccata taaaagaagc tgcgcagctt tcaggtgtct ctgtcaagac cctgcatcac   60
tatgacaaga taggactctt ggtcccctta aagtcggaaa acggctatcg aacctacagt   120
caagaggatt tggaacgcct tcaggtcatt ctttactaca aatatctagg cttttcttta   180
gagaaaatag cagagctgtt aaaggaagaa aggacagatt tattgcccca tttgactagg   240
cagttggact atctaactcg cgaaaggcaa catctggata ccttgatttc caccttgcaa   300
aaaactattc aagaacaaaa aggagaaaga aaaatgacca ttgaggaaaa attcacggga   360
tttagctatc aagacaatca aaaataccac caagaagcgg tagagaaata tggtcaagaa   420
gtcatgggac aagcgctcga acgccaaaaa ggtcacgaag acgaggctac ggccgccttt   480
aaccaagtct ttcaaacttt ggcacaaaat cttcaagttg gtttacctgc aacagcaacc   540
gaaaaccagg agcaagcagc caagctcttg caagccattc gcacttatgg atttgactgc   600
tctattgagg tattcggtca tatcggtaaa ggttacgtct acaacccaga gtttaaggaa   660
aacattgaca agtttggttc tgaaacagcc cagtacacgt cagatgccat tgcggtttac   720
gttcagacaa atgcagaa                                                 738

<210>   1394
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, MerR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902693 (e-124)

<400>   1394
Met Tyr His Ile Lys Glu Ala Ala Gln Leu Ser Gly Val Ser Val Lys 
1               5                   10                  15      

Thr Leu His His Tyr Asp Lys Ile Gly Leu Leu Val Pro Leu Lys Ser 
            20                  25                  30          

Glu Asn Gly Tyr Arg Thr Tyr Ser Gln Glu Asp Leu Glu Arg Leu Gln 
        35                  40                  45              

Val Ile Leu Tyr Tyr Lys Tyr Leu Gly Phe Ser Leu Glu Lys Ile Ala 
    50                  55                  60                  

Glu Leu Leu Lys Glu Glu Arg Thr Asp Leu Leu Pro His Leu Thr Arg 
65                  70                  75                  80  

Gln Leu Asp Tyr Leu Thr Arg Glu Arg Gln His Leu Asp Thr Leu Ile 
                85                  90                  95      

Ser Thr Leu Gln Lys Thr Ile Gln Glu Gln Lys Gly Glu Arg Lys Met 
            100                 105                 110         

Thr Ile Glu Glu Lys Phe Thr Gly Phe Ser Tyr Gln Asp Asn Gln Lys 
        115                 120                 125             

Tyr His Gln Glu Ala Val Glu Lys Tyr Gly Gln Glu Val Met Gly Gln 
    130                 135                 140                 

Ala Leu Glu Arg Gln Lys Gly His Glu Asp Glu Ala Thr Ala Ala Phe 
145                 150                 155                 160 

Asn Gln Val Phe Gln Thr Leu Ala Gln Asn Leu Gln Val Gly Leu Pro 
                165                 170                 175     

Ala Thr Ala Thr Glu Asn Gln Glu Gln Ala Ala Lys Leu Leu Gln Ala 
            180                 185                 190         

Ile Arg Thr Tyr Gly Phe Asp Cys Ser Ile Glu Val Phe Gly His Ile 
        195                 200                 205             

Gly Lys Gly Tyr Val Tyr Asn Pro Glu Phe Lys Glu Asn Ile Asp Lys 
    210                 215                 220                 

Phe Gly Ser Glu Thr Ala Gln Tyr Thr Ser Asp Ala Ile Ala Val Tyr 
225                 230                 235                 240 

Val Gln Thr Asn Ala Glu 
                245     

<210>   1395
<211>   453
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1395
atgaacagaa gagaggcagt cgaatttgtt aacatgtgta tgattaaaaa cggagataag   60
gtcctggtcc aagaccgagt taatcccgac tggtctggca ttacttttcc tggtggtcat   120
gttgaacgtg gcgaatcctt tgtcgatgct gtcattcgtg aagtgaaaga agaaactggt   180
ctgatcattt ccaaacccca actctgtggt atcaaaaact ggtatgacga caaggattat   240
cgttatgtcg tcctttttta caagacagaa cactttactg gtgaactcca gtcttcagac   300
gaagggaaag tttggtggga ggactttgaa aatctttctc atctaaaact tgcaaccgat   360
gatatgtctg atatgcttcg tgtgtttcta gaagaagatc tcagtgaatt cttttactac   420
aaaaacggtg acgactggct ttatgatttg aag                                453

<210>   1396
<211>   151
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MutT/nudix family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902694 (3.E-88)

<400>   1396
Met Asn Arg Arg Glu Ala Val Glu Phe Val Asn Met Cys Met Ile Lys 
1               5                   10                  15      

Asn Gly Asp Lys Val Leu Val Gln Asp Arg Val Asn Pro Asp Trp Ser 
            20                  25                  30          

Gly Ile Thr Phe Pro Gly Gly His Val Glu Arg Gly Glu Ser Phe Val 
        35                  40                  45              

Asp Ala Val Ile Arg Glu Val Lys Glu Glu Thr Gly Leu Ile Ile Ser 
    50                  55                  60                  

Lys Pro Gln Leu Cys Gly Ile Lys Asn Trp Tyr Asp Asp Lys Asp Tyr 
65                  70                  75                  80  

Arg Tyr Val Val Leu Phe Tyr Lys Thr Glu His Phe Thr Gly Glu Leu 
                85                  90                  95      

Gln Ser Ser Asp Glu Gly Lys Val Trp Trp Glu Asp Phe Glu Asn Leu 
            100                 105                 110         

Ser His Leu Lys Leu Ala Thr Asp Asp Met Ser Asp Met Leu Arg Val 
        115                 120                 125             

Phe Leu Glu Glu Asp Leu Ser Glu Phe Phe Tyr Tyr Lys Asn Gly Asp 
    130                 135                 140                 

Asp Trp Leu Tyr Asp Leu Lys 
145                 150     

<210>   1397
<211>   1173
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1397
atgaaacatt ttgatactat tgtcatcggt gggggacctg ctggtatgat ggctacgatt   60
tccagtagct tttatggaca gaaaaccctc ctcatcgaaa aaaatcggaa acttggaaaa   120
aaattagctg ggactggtgg gggacgttgc aatgtgacca acaatggtag cttagacaac   180
ctgctagctg gaattcctgg aaacggacgc tttctttaca gtgttttctc ccagttcgat   240
aatcatgaca tcatcaactt ttttacagaa aatggtgtta aacttaaggt cgaagaccac   300
ggacgcgtct ttccagccag tgacaagtct cggactatta tcgaagcttt ggaaaagaaa   360
atcaccgaac taggtggtca agttgctact caaatagaaa tcgtttctgt taaaaaagta   420
gatgaccagt ttgtccttaa gtcagcggat caaaccttca cttgtgagaa actcattgtc   480
acaacaggtg gtaagtctta tccttcgact ggttcgactg gttttggtca cgagattgct   540
cgccatttta agcataccat caccgatctt gaggctgctg aaagtccttt attaacagat   600
tttccacata aagccttaca aggtatttct ctggacgatg tgaccctaag ttatggtaag   660
catgtcatca ctcatgattt actctttacc cactttggtt tgtcaggtcc tgctgcccta   720
cgcatgtcta gctttgtcaa aggtggggag gttctctcac tcgatgtttt gcctcaactt   780
tctgagaagg acttggttac atttctagaa gaaaatcggg aaaaatcctt gaaaaacgct   840
ttaaaaacct tgttaccaga acgcttggcc gaattttttg tacaaggata tcctgaaaaa   900
gtcaaacaac tgactgaaaa ggaacgagaa caacttgtcc agtccattaa agaacttaaa   960
attcctgtaa ctggaaaaat gtcccttgca aagtcctttg ttaccaaggg tggagtcagt   1020
ctcaaggaaa tcaatcctaa aacccttgaa agtaagctgg tacctggcct ccactttgca   1080
ggcgaagtta tggatatcaa tgcccacacg ggtggcttta acatcacttc tgccctctgt   1140
accggctggg tggcgggaag tctgcattat gat                                1173

<210>   1398
<211>   391
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902695 (0.E+01)

<400>   1398
Met Lys His Phe Asp Thr Ile Val Ile Gly Gly Gly Pro Ala Gly Met 
1               5                   10                  15      

Met Ala Thr Ile Ser Ser Ser Phe Tyr Gly Gln Lys Thr Leu Leu Ile 
            20                  25                  30          

Glu Lys Asn Arg Lys Leu Gly Lys Lys Leu Ala Gly Thr Gly Gly Gly 
        35                  40                  45              

Arg Cys Asn Val Thr Asn Asn Gly Ser Leu Asp Asn Leu Leu Ala Gly 
    50                  55                  60                  

Ile Pro Gly Asn Gly Arg Phe Leu Tyr Ser Val Phe Ser Gln Phe Asp 
65                  70                  75                  80  

Asn His Asp Ile Ile Asn Phe Phe Thr Glu Asn Gly Val Lys Leu Lys 
                85                  90                  95      

Val Glu Asp His Gly Arg Val Phe Pro Ala Ser Asp Lys Ser Arg Thr 
            100                 105                 110         

Ile Ile Glu Ala Leu Glu Lys Lys Ile Thr Glu Leu Gly Gly Gln Val 
        115                 120                 125             

Ala Thr Gln Ile Glu Ile Val Ser Val Lys Lys Val Asp Asp Gln Phe 
    130                 135                 140                 

Val Leu Lys Ser Ala Asp Gln Thr Phe Thr Cys Glu Lys Leu Ile Val 
145                 150                 155                 160 

Thr Thr Gly Gly Lys Ser Tyr Pro Ser Thr Gly Ser Thr Gly Phe Gly 
                165                 170                 175     

His Glu Ile Ala Arg His Phe Lys His Thr Ile Thr Asp Leu Glu Ala 
            180                 185                 190         

Ala Glu Ser Pro Leu Leu Thr Asp Phe Pro His Lys Ala Leu Gln Gly 
        195                 200                 205             

Ile Ser Leu Asp Asp Val Thr Leu Ser Tyr Gly Lys His Val Ile Thr 
    210                 215                 220                 

His Asp Leu Leu Phe Thr His Phe Gly Leu Ser Gly Pro Ala Ala Leu 
225                 230                 235                 240 

Arg Met Ser Ser Phe Val Lys Gly Gly Glu Val Leu Ser Leu Asp Val 
                245                 250                 255     

Leu Pro Gln Leu Ser Glu Lys Asp Leu Val Thr Phe Leu Glu Glu Asn 
            260                 265                 270         

Arg Glu Lys Ser Leu Lys Asn Ala Leu Lys Thr Leu Leu Pro Glu Arg 
        275                 280                 285             

Leu Ala Glu Phe Phe Val Gln Gly Tyr Pro Glu Lys Val Lys Gln Leu 
    290                 295                 300                 

Thr Glu Lys Glu Arg Glu Gln Leu Val Gln Ser Ile Lys Glu Leu Lys 
305                 310                 315                 320 

Ile Pro Val Thr Gly Lys Met Ser Leu Ala Lys Ser Phe Val Thr Lys 
                325                 330                 335     

Gly Gly Val Ser Leu Lys Glu Ile Asn Pro Lys Thr Leu Glu Ser Lys 
            340                 345                 350         

Leu Val Pro Gly Leu His Phe Ala Gly Glu Val Met Asp Ile Asn Ala 
        355                 360                 365             

His Thr Gly Gly Phe Asn Ile Thr Ser Ala Leu Cys Thr Gly Trp Val 
    370                 375                 380                 

Ala Gly Ser Leu His Tyr Asp 
385                 390     

<210>   1399
<211>   843
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1399
atgacttgga agattattgc tgactctggt tgtgattatc gtcaactgcc aacaccagct   60
attaacacaa cctttgtaag tgtcccctta accattcaag tagctgatca ggtctttgtt   120
gatgacgcca gtctcgatat tgaccaaatg atggaaacca tgtatgcaac tgcagaagct   180
tcaaaatcgg cttgtccaag cccagatgac tatttgcgag catttgaagg tgccaaaaac   240
attttcctag taaccatcac aggtaccctt tctggcagtc acaatagtgc tcaactagca   300
aagaatattt atctggaaga ccatcctgac actaagattc atgtgattga tagtttatct   360
gctggtggtg aagttgacct actcgtagaa aaattgaatg acttgattga ccagggcttg   420
tcttttgaag aagtggttga agctatcacc gcctatcaag aaaaaactaa gttgctcttt   480
gtcctagcca aagtcgataa cttggtgaag aacggccgtt tgagcaagct tatcggtacg   540
gtcgttggcc ttctcaacat tcgtatggtc ggaaaagcta gtgaaactgg gactctcgaa   600
ttgctacaaa aagcaagggg atcaaagaaa tcagttcaag ctgcctatga tgagttagta   660
aaagctggat atgctggtgg ccgtattgtc atggcccaac gcaataacga aaaatgttgt   720
caacagctct cagagcgaat ccgtgaaacc ttcccacaag cggatattaa aattctacca   780
acctctggtc tctgcagttt ctatgcagaa gagggcggtt tgctgatggg ctatgaaatt   840
gat                                                                 843

<210>   1400
<211>   281
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902696 (e-158)

<400>   1400
Met Thr Trp Lys Ile Ile Ala Asp Ser Gly Cys Asp Tyr Arg Gln Leu 
1               5                   10                  15      

Pro Thr Pro Ala Ile Asn Thr Thr Phe Val Ser Val Pro Leu Thr Ile 
            20                  25                  30          

Gln Val Ala Asp Gln Val Phe Val Asp Asp Ala Ser Leu Asp Ile Asp 
        35                  40                  45              

Gln Met Met Glu Thr Met Tyr Ala Thr Ala Glu Ala Ser Lys Ser Ala 
    50                  55                  60                  

Cys Pro Ser Pro Asp Asp Tyr Leu Arg Ala Phe Glu Gly Ala Lys Asn 
65                  70                  75                  80  

Ile Phe Leu Val Thr Ile Thr Gly Thr Leu Ser Gly Ser His Asn Ser 
                85                  90                  95      

Ala Gln Leu Ala Lys Asn Ile Tyr Leu Glu Asp His Pro Asp Thr Lys 
            100                 105                 110         

Ile His Val Ile Asp Ser Leu Ser Ala Gly Gly Glu Val Asp Leu Leu 
        115                 120                 125             

Val Glu Lys Leu Asn Asp Leu Ile Asp Gln Gly Leu Ser Phe Glu Glu 
    130                 135                 140                 

Val Val Glu Ala Ile Thr Ala Tyr Gln Glu Lys Thr Lys Leu Leu Phe 
145                 150                 155                 160 

Val Leu Ala Lys Val Asp Asn Leu Val Lys Asn Gly Arg Leu Ser Lys 
                165                 170                 175     

Leu Ile Gly Thr Val Val Gly Leu Leu Asn Ile Arg Met Val Gly Lys 
            180                 185                 190         

Ala Ser Glu Thr Gly Thr Leu Glu Leu Leu Gln Lys Ala Arg Gly Ser 
        195                 200                 205             

Lys Lys Ser Val Gln Ala Ala Tyr Asp Glu Leu Val Lys Ala Gly Tyr 
    210                 215                 220                 

Ala Gly Gly Arg Ile Val Met Ala Gln Arg Asn Asn Glu Lys Cys Cys 
225                 230                 235                 240 

Gln Gln Leu Ser Glu Arg Ile Arg Glu Thr Phe Pro Gln Ala Asp Ile 
                245                 250                 255     

Lys Ile Leu Pro Thr Ser Gly Leu Cys Ser Phe Tyr Ala Glu Glu Gly 
            260                 265                 270         

Gly Leu Leu Met Gly Tyr Glu Ile Asp 
        275                 280     

<210>   1401
<211>   555
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1401
atgtctgaac gtagaatctc tgaaaagtct cttgaaaatc tcagaaaatc aaaccaagaa   60
tccaatttat taaccagaga agccattgaa acagccctct tgcaactctt ggaaaaaaag   120
gaactgacca agattagtat ttctgaattg gtcaaacgtg caggtgtttc gcgtgcggcc   180
ttttatcgca attatgactc caaagaggaa attttagaga gcgtctttaa acgaactgtc   240
cacaatatta tggaacagct gcatcattac gatttaaaga cagaccttta tttggtttgg   300
gttcaccttt tccgggaggc cagaaaggaa gctagagtaa ttcaattggc cttggattac   360
catctggaaa aaatctttgt ccaagccatg caggaatttc tagaaaaata ccatgggaaa   420
tcaaaaggtg tcagctctta tcttcattcc ttctggagct cagccatcgt ctctgtcctt   480
ctaaaatgga tcaaggatgg catgaaggta ccagctgaaa agattgcaga tttaggttta   540
ccatttttta aaaaa                                                    555

<210>   1402
<211>   185
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, TetR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902697 (e-102)

<400>   1402
Met Ser Glu Arg Arg Ile Ser Glu Lys Ser Leu Glu Asn Leu Arg Lys 
1               5                   10                  15      

Ser Asn Gln Glu Ser Asn Leu Leu Thr Arg Glu Ala Ile Glu Thr Ala 
            20                  25                  30          

Leu Leu Gln Leu Leu Glu Lys Lys Glu Leu Thr Lys Ile Ser Ile Ser 
        35                  40                  45              

Glu Leu Val Lys Arg Ala Gly Val Ser Arg Ala Ala Phe Tyr Arg Asn 
    50                  55                  60                  

Tyr Asp Ser Lys Glu Glu Ile Leu Glu Ser Val Phe Lys Arg Thr Val 
65                  70                  75                  80  

His Asn Ile Met Glu Gln Leu His His Tyr Asp Leu Lys Thr Asp Leu 
                85                  90                  95      

Tyr Leu Val Trp Val His Leu Phe Arg Glu Ala Arg Lys Glu Ala Arg 
            100                 105                 110         

Val Ile Gln Leu Ala Leu Asp Tyr His Leu Glu Lys Ile Phe Val Gln 
        115                 120                 125             

Ala Met Gln Glu Phe Leu Glu Lys Tyr His Gly Lys Ser Lys Gly Val 
    130                 135                 140                 


Ser Ser Tyr Leu His Ser Phe Trp Ser Ser Ala Ile Val Ser Val Leu 
145                 150                 155                 160 

Leu Lys Trp Ile Lys Asp Gly Met Lys Val Pro Ala Glu Lys Ile Ala 
                165                 170                 175     

Asp Leu Gly Leu Pro Phe Phe Lys Lys 
            180                 185 

<210>   1403
<211>   465
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1403
atgactgaaa aaagactggc ctgggatgag tattttgcag cccaagctct actaattgcg   60
aatcgttcca cttgtaaacg tgctaaagtg ggcgcgattc tggtaaaaga taataaggtt   120
atttccactg gttacaatgg ttcggtgtca gggactgagc attgtattga tcacgaatgt   180
ttggtcattg aaggccactg cgttcgcacc cttcacgctg aggtcaatgc tatccttcaa   240
ggtgctgagc gtggtgttcc caaaggcttt acagcctatg taacccattt tccttgtctc   300
aactgtacaa aacaattgct tcaggtcggc tgcaagcgcg tggtttatat caaccagtac   360
cgaatggacg actacgccca atacctttat caagaaaaag ggacagaatt gacccattta   420
ccacttgaga cagtacagac agctcttaaa gaggctgatc taatg                   465

<210>   1404
<211>   155
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cytidine and deoxycytidylate deaminase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902698 (2.E-89)

<400>   1404
Met Thr Glu Lys Arg Leu Ala Trp Asp Glu Tyr Phe Ala Ala Gln Ala 
1               5                   10                  15      

Leu Leu Ile Ala Asn Arg Ser Thr Cys Lys Arg Ala Lys Val Gly Ala 
            20                  25                  30          

Ile Leu Val Lys Asp Asn Lys Val Ile Ser Thr Gly Tyr Asn Gly Ser 
        35                  40                  45              

Val Ser Gly Thr Glu His Cys Ile Asp His Glu Cys Leu Val Ile Glu 
    50                  55                  60                  

Gly His Cys Val Arg Thr Leu His Ala Glu Val Asn Ala Ile Leu Gln 
65                  70                  75                  80  

Gly Ala Glu Arg Gly Val Pro Lys Gly Phe Thr Ala Tyr Val Thr His 
                85                  90                  95      

Phe Pro Cys Leu Asn Cys Thr Lys Gln Leu Leu Gln Val Gly Cys Lys 
            100                 105                 110         

Arg Val Val Tyr Ile Asn Gln Tyr Arg Met Asp Asp Tyr Ala Gln Tyr 
        115                 120                 125             

Leu Tyr Gln Glu Lys Gly Thr Glu Leu Thr His Leu Pro Leu Glu Thr 
    130                 135                 140                 

Val Gln Thr Ala Leu Lys Glu Ala Asp Leu Met 
145                 150                 155 

<210>   1405
<211>   648
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1405
ttgaaagaag gaattccaaa aatgggaaaa attgaagtta ttaatcaccc actgattcaa   60
cacaaattgt caatcttgcg tcgtacagat acttctacaa aagcttttcg tgagctagta   120
gatgagattg caatgttgat ggggtatgaa gtacttcgtg atcttccact agaagatgtg   180
gaaatcgaaa caccaattac aaaaacagtt caaaaacaat tggcaggtaa gaaattggcc   240
atcgtcccaa tcttgcgtgc aggtatcggg atggttgatg gtctcttgaa cttggttcca   300
gctgctaaag ttggccacat cggtatgtac cgtgatgaag aaacacttca accagttgaa   360
tacttggtga aattgcctga ggacattgac caacgtcaaa tttttgtagt agacccaatg   420
ttggcaacag gtggctcagc aatcttggct gttgattctc ttaaaaaacg tggcgcatca   480
aatatcaaat ttgtctgcct tgtatctgct ccagagggtg taaaagccct tcaagaagct   540
catccagatg tagaaatctt tacagcagcc ttggatgaac gtttgaacga acacggttat   600
atcgttccag gtcttggaga tgctggagac cgcttgttcg gtacaaaa                648

<210>   1406
<211>   216
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   uracil phosphoribosyltransferase (upp)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902699 (e-115)

<400>   1406
Met Lys Glu Gly Ile Pro Lys Met Gly Lys Ile Glu Val Ile Asn His 
1               5                   10                  15      

Pro Leu Ile Gln His Lys Leu Ser Ile Leu Arg Arg Thr Asp Thr Ser 
            20                  25                  30          

Thr Lys Ala Phe Arg Glu Leu Val Asp Glu Ile Ala Met Leu Met Gly 
        35                  40                  45              

Tyr Glu Val Leu Arg Asp Leu Pro Leu Glu Asp Val Glu Ile Glu Thr 
    50                  55                  60                  

Pro Ile Thr Lys Thr Val Gln Lys Gln Leu Ala Gly Lys Lys Leu Ala 
65                  70                  75                  80  

Ile Val Pro Ile Leu Arg Ala Gly Ile Gly Met Val Asp Gly Leu Leu 
                85                  90                  95      

Asn Leu Val Pro Ala Ala Lys Val Gly His Ile Gly Met Tyr Arg Asp 
            100                 105                 110         

Glu Glu Thr Leu Gln Pro Val Glu Tyr Leu Val Lys Leu Pro Glu Asp 
        115                 120                 125             

Ile Asp Gln Arg Gln Ile Phe Val Val Asp Pro Met Leu Ala Thr Gly 
    130                 135                 140                 

Gly Ser Ala Ile Leu Ala Val Asp Ser Leu Lys Lys Arg Gly Ala Ser 
145                 150                 155                 160 


Asn Ile Lys Phe Val Cys Leu Val Ser Ala Pro Glu Gly Val Lys Ala 
                165                 170                 175     

Leu Gln Glu Ala His Pro Asp Val Glu Ile Phe Thr Ala Ala Leu Asp 
            180                 185                 190         

Glu Arg Leu Asn Glu His Gly Tyr Ile Val Pro Gly Leu Gly Asp Ala 
        195                 200                 205             

Gly Asp Arg Leu Phe Gly Thr Lys 
    210                 215     

<210>   1407
<211>   588
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   1407
atgattcctg tagttattga acaaacaagc cgtggagaac gttcttacga tatttactca   60
cgtcttctca aagaccgcat cattatgctg acaggtccgg ttgaagacaa tatggctaac   120
tctgttattg cccaattgct tttcttggat gcccaagata gtacaaaaga tatttacctt   180
tatgtcaata caccaggtgg ttctgtttca gctggtttgg caatcgtaga taccatgaac   240
tttatcaagg cagatgtcca aaccattgtt atgggaatgg ctgcatctat ggggactgtc   300
atcgcatcaa gtggagcaaa aggcaaacgt ttcatgcttc caaatgctga atacatgatt   360
caccaaccaa tgggtggtac aggtggtggt acccaacaaa ctgatatggc tatcgctgca   420
gaacacttgc tcaaaactcg taataccttg gaaaaaatct tggctgaaaa ttcaggtcag   480
tcaatggaaa aagtccatgc agatgcagaa cgtgataact ggatgagcgc ccaggaaaca   540
cttgaatatg gctttattga tgaaattatg gccaacaatt cattgaac                588

<210>   1408
<211>   196
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent Clp protease, proteolytic subunit (clpP)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902700 (e-108)

<400>   1408
Met Ile Pro Val Val Ile Glu Gln Thr Ser Arg Gly Glu Arg Ser Tyr 
1               5                   10                  15      

Asp Ile Tyr Ser Arg Leu Leu Lys Asp Arg Ile Ile Met Leu Thr Gly 
            20                  25                  30          

Pro Val Glu Asp Asn Met Ala Asn Ser Val Ile Ala Gln Leu Leu Phe 
        35                  40                  45              

Leu Asp Ala Gln Asp Ser Thr Lys Asp Ile Tyr Leu Tyr Val Asn Thr 
    50                  55                  60                  

Pro Gly Gly Ser Val Ser Ala Gly Leu Ala Ile Val Asp Thr Met Asn 
65                  70                  75                  80  

Phe Ile Lys Ala Asp Val Gln Thr Ile Val Met Gly Met Ala Ala Ser 
                85                  90                  95      

Met Gly Thr Val Ile Ala Ser Ser Gly Ala Lys Gly Lys Arg Phe Met 
            100                 105                 110         

Leu Pro Asn Ala Glu Tyr Met Ile His Gln Pro Met Gly Gly Thr Gly 
        115                 120                 125             

Gly Gly Thr Gln Gln Thr Asp Met Ala Ile Ala Ala Glu His Leu Leu 
    130                 135                 140                 

Lys Thr Arg Asn Thr Leu Glu Lys Ile Leu Ala Glu Asn Ser Gly Gln 
145                 150                 155                 160 

Ser Met Glu Lys Val His Ala Asp Ala Glu Arg Asp Asn Trp Met Ser 
                165                 170                 175     

Ala Gln Glu Thr Leu Glu Tyr Gly Phe Ile Asp Glu Ile Met Ala Asn 
            180                 185                 190         

Asn Ser Leu Asn 
        195     

<210>   1409
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1409
ttgacttttt caaacatgat aaatcctctt tctaagaaat ctctccctat tataccaaaa   60
aaagcaaacc cagtcgagtt tgccttctat catcat                             96

<210>   1410
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1410
Met Thr Phe Ser Asn Met Ile Asn Pro Leu Ser Lys Lys Ser Leu Pro 
1               5                   10                  15      

Ile Ile Pro Lys Lys Ala Asn Pro Val Glu Phe Ala Phe Tyr His His 
            20                  25                  30          


<210>   1411
<211>   246
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1411
atgtttgaaa aagtcaatcg ctctggcttg attatctatc tttactataa tcgtgatgcc   60
aaaaaactgc aggattatgg agatattacc tatcattcca agaaacatcg ttacttacaa   120
ctctatgttc caactcaaga agtggagcaa ttggtcggac gcttgagcaa ggaaaaattt   180
attaaaaaag ttagggtttg tcatatccaa gagttggaaa caccctttgt gggcaatctt   240
tatcga                                                              246

<210>   1412
<211>   82
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902701 (1.E-44)

<400>   1412
Met Phe Glu Lys Val Asn Arg Ser Gly Leu Ile Ile Tyr Leu Tyr Tyr 
1               5                   10                  15      

Asn Arg Asp Ala Lys Lys Leu Gln Asp Tyr Gly Asp Ile Thr Tyr His 
            20                  25                  30          

Ser Lys Lys His Arg Tyr Leu Gln Leu Tyr Val Pro Thr Gln Glu Val 
        35                  40                  45              

Glu Gln Leu Val Gly Arg Leu Ser Lys Glu Lys Phe Ile Lys Lys Val 
    50                  55                  60                  

Arg Val Cys His Ile Gln Glu Leu Glu Thr Pro Phe Val Gly Asn Leu 
65                  70                  75                  80  

Tyr Arg 
        

<210>   1413
<211>   1157
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1413
atgaagaaaa aatttgccct atcgtttgtg gcgcttgcaa gtgtagcact tcttgcagcc   60
tgtggagaag tgaagtctgg agcagtcaac actgctggta actcagtaga ggaaaagaca   120
attaaaatcg ggtttaactt tgaagaatca ggttctttag ctgcatacgg aacagctgaa   180
caaaaaggtg cccaattggc tgttgatgaa atcaatgccg cagtggtatc gatggaaaac   240
aaatcgaagt agtcgataaa gataataagt ctgaaacagc tgaggctgct tcagttacaa   300
ctaaccttgt aacccaatct aaagtatcag cagtcgtagg acctgcgaca tctggtgcga   360
ctgcagctgc ggtagcgaac gctacaaaag caggtgttcc attgatctca ccaagtgcga   420
ctcaagatgg attgactaaa ggtcaagatt acctctttat tggaactttc caagatagct   480
tccaaggaaa aattatctca aactatgttt ctgaaaaatt aaatgctaag aaagttgttc   540
tttacactga caatgccagt gactatgcta aagggattgc aaaatctttc cgcgagtcat   600
acaagggtga aatcgttgca gatgaaactt tcgtagcagg tgacacagac ttccaagcag   660
cccttacaaa aatgaaaggg aaagactttg atgctatcgt tgttcctggt tactataatg   720
aggctggtaa aattgtaaac caagcgcgtg gcatgggaat tgacaaacca atcgttggtg   780
gtgatggatt caacggtgag gagtttgtac aacaagcaac tgctgaaaaa gcatcaaaca   840
tctactttat ctcaggcttc tcaactactg tagaagtttc agctaaagct aaagccttcc   900
ttgacgctta ccgtgctaag tacaatgaag agccttcaac atttgcagcc ttggcttatg   960
attcagttca ccttgtagca aacgcagcaa aaggtgctaa aaattcaggt gaaatcaaga   1020
ataaccttgc taaaacaaaa gattttgaag gtgtaactgg tcaaacaagc ttcgatgcag   1080
accacaacac agtcaaaact gcttacatga tgaccatgaa caatggtaaa gttgaagcag   1140
cagaagttgt aaaacca                                                  1157

<210>   1414
<211>   83
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   branched-chain amino acid ABC transporter, amino acid-binding protein (

<400>   1414
Met Lys Lys Lys Phe Ala Leu Ser Phe Val Ala Leu Ala Ser Val Ala 
1               5                   10                  15      

Leu Leu Ala Ala Cys Gly Glu Val Lys Ser Gly Ala Val Asn Thr Ala 
            20                  25                  30          

Gly Asn Ser Val Glu Glu Lys Thr Ile Lys Ile Gly Phe Asn Phe Glu 
        35                  40                  45              

Glu Ser Gly Ser Leu Ala Ala Tyr Gly Thr Ala Glu Gln Lys Gly Ala 
    50                  55                  60                  

Gln Leu Ala Val Asp Glu Ile Asn Ala Ala Val Val Ser Met Glu Asn 
65                  70                  75                  80  


Lys Ser Lys 
            

<210>   1415
<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1415
ttgtctcctt atttcttaaa tagtctgtta agaatatacc gaattatcag aaaattgtca   60
atgttttcct tgaacttttt cgatgataac gttttcctat cgataaagat tgcccacaaa   120
gggtgtttcc aactcttgga tatgacaaac cctaactttt ttaataaatt tttccttgct   180
caagcgtccg accaattgct ccacttcttg agttggaaca tagagttg                228

<210>   1416
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1416
Met Ser Pro Tyr Phe Leu Asn Ser Leu Leu Arg Ile Tyr Arg Ile Ile 
1               5                   10                  15      

Arg Lys Leu Ser Met Phe Ser Leu Asn Phe Phe Asp Asp Asn Val Phe 
            20                  25                  30          

Leu Ser Ile Lys Ile Ala His Lys Gly Cys Phe Gln Leu Leu Asp Met 
        35                  40                  45              

Thr Asn Pro Asn Phe Phe Asn Lys Phe Phe Leu Ala Gln Ala Ser Asp 
    50                  55                  60                  

Gln Leu Leu His Phe Leu Ser Trp Asn Ile Glu Leu 
65                  70                  75      

<210>   1417
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1417
ttgatctcac caagtgcgac tcaagatgga ttgactaaag gtcaagatta cctctttatt   60
ggaactttcc aagatagctt ccaaggaaaa attatctcaa actatgtttc tgaaaaatta   120
aatgctaaga aagttgttct ttacactgac aatgccagtg actatgctaa agggattgca   180
aaatctttcc gcgagtcata caagggtgaa atcgttgcag atgaaacttt cgtagcaggt   240
gacacagact tccaagcagc ccttacaaaa atgaaaggga aagactttga tgctatcgtt   300
gttcctggtt actataatga ggctggtaaa attgtaaacc aagcgcgtgg catgggaatt   360
gacaaaccaa tcgttggtgg tgatggattc aacggtgagg agtttgtaca acaagcaact   420
gctgaaaaag catcaaacat ctactttatc tcaggcttct caactactgt agaagtttca   480
gctaaagcta aagccttcct tgacgcttac cgtgctaagt acaatgaaga gccttcaaca   540
tttgcagcct tggcttatga ttcagttcac cttgtagcaa acgcagcaaa aggtgctaaa   600
aattcaggtg aaatcaagaa taaccttgct aaaacaaaag attttgaagg tgtaactggt   660
caaacaagct tcgatgcaga ccacaacaca gtcaaaactg cttacatgat gaccatgaac   720
aatggtaaag ttgaagcagc agaagttgta aaacca                             756

<210>   1418
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   branched chain amino acid ABC transporter, periplasmic amino acid-bindi

<400>   1418
Met Ile Ser Pro Ser Ala Thr Gln Asp Gly Leu Thr Lys Gly Gln Asp 
1               5                   10                  15      

Tyr Leu Phe Ile Gly Thr Phe Gln Asp Ser Phe Gln Gly Lys Ile Ile 
            20                  25                  30          

Ser Asn Tyr Val Ser Glu Lys Leu Asn Ala Lys Lys Val Val Leu Tyr 
        35                  40                  45              

Thr Asp Asn Ala Ser Asp Tyr Ala Lys Gly Ile Ala Lys Ser Phe Arg 
    50                  55                  60                  

Glu Ser Tyr Lys Gly Glu Ile Val Ala Asp Glu Thr Phe Val Ala Gly 
65                  70                  75                  80  

Asp Thr Asp Phe Gln Ala Ala Leu Thr Lys Met Lys Gly Lys Asp Phe 
                85                  90                  95      

Asp Ala Ile Val Val Pro Gly Tyr Tyr Asn Glu Ala Gly Lys Ile Val 
            100                 105                 110         

Asn Gln Ala Arg Gly Met Gly Ile Asp Lys Pro Ile Val Gly Gly Asp 
        115                 120                 125             

Gly Phe Asn Gly Glu Glu Phe Val Gln Gln Ala Thr Ala Glu Lys Ala 
    130                 135                 140                 

Ser Asn Ile Tyr Phe Ile Ser Gly Phe Ser Thr Thr Val Glu Val Ser 
145                 150                 155                 160 

Ala Lys Ala Lys Ala Phe Leu Asp Ala Tyr Arg Ala Lys Tyr Asn Glu 
                165                 170                 175     

Glu Pro Ser Thr Phe Ala Ala Leu Ala Tyr Asp Ser Val His Leu Val 
            180                 185                 190         

Ala Asn Ala Ala Lys Gly Ala Lys Asn Ser Gly Glu Ile Lys Asn Asn 
        195                 200                 205             

Leu Ala Lys Thr Lys Asp Phe Glu Gly Val Thr Gly Gln Thr Ser Phe 
    210                 215                 220                 

Asp Ala Asp His Asn Thr Val Lys Thr Ala Tyr Met Met Thr Met Asn 
225                 230                 235                 240 

Asn Gly Lys Val Glu Ala Ala Glu Val Val Lys Pro 
                245                 250         

<210>   1419
<211>   867
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1419
atgctccaac aactcgtaaa tggtttgatt ctaggtagtg tttacgcgct gttagcccta   60
ggatatacca tggtttacgg aattatcaag ctcatcaact tcgcccatgg tgatatttat   120
atgatgggag cctttatcgg ttatttcttg atcaattctt tccaaatgaa tttctttgta   180
gcgcttattg tagctatgct agcgacagct attcttggtg tcgtgattga gtttcttgct   240
taccgacctt tgcgccactc tactcgtatt gctgttttga ttacggctat tggggtttct   300
ttcctattgg agtatggaat ggtctatctg gttggtgcca atacccgtgc cttccctcaa   360
gcgattcaaa cagttcgata tgatttggga ccaattagct taacaaatgt gcagttaatg   420
attttggcca tttccttgat tttgatgatt ttgttacaag tcattgtcca aaagactaag   480
atggggaaag ccatgcgtgc agtatcagta gatagcgacg cggcgcaatt gatggggatc   540
aatgtaaacc gtacgattag ctttaccttc gctttgggtt ctgctcttgc gggtgcggct   600
ggtgttctga ttgctcttta ttataactct cttgagcctt tgatgggggt tactccaggt   660
cttaaatctt tcgttgccgc agtacttggt ggtatcggaa ttattcctgg tgcggctctt   720
ggtggctttg tgattggtct attggaaacc tttgcgactg cctttgggat gtcagatttc   780
cgtgatgcca ttgtttatgg aatcttgttg ttgatcttga ttgtccgccc agctggtatc   840
cttggtaaga atgtgaaaga gaaggtg                                       867

<210>   1420
<211>   289
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   branched-chain amino acid ABC transporter, permease protein (livH)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902704 (e-156)

<400>   1420
Met Leu Gln Gln Leu Val Asn Gly Leu Ile Leu Gly Ser Val Tyr Ala 
1               5                   10                  15      

Leu Leu Ala Leu Gly Tyr Thr Met Val Tyr Gly Ile Ile Lys Leu Ile 
            20                  25                  30          

Asn Phe Ala His Gly Asp Ile Tyr Met Met Gly Ala Phe Ile Gly Tyr 
        35                  40                  45              

Phe Leu Ile Asn Ser Phe Gln Met Asn Phe Phe Val Ala Leu Ile Val 
    50                  55                  60                  

Ala Met Leu Ala Thr Ala Ile Leu Gly Val Val Ile Glu Phe Leu Ala 
65                  70                  75                  80  

Tyr Arg Pro Leu Arg His Ser Thr Arg Ile Ala Val Leu Ile Thr Ala 
                85                  90                  95      

Ile Gly Val Ser Phe Leu Leu Glu Tyr Gly Met Val Tyr Leu Val Gly 
            100                 105                 110         

Ala Asn Thr Arg Ala Phe Pro Gln Ala Ile Gln Thr Val Arg Tyr Asp 
        115                 120                 125             

Leu Gly Pro Ile Ser Leu Thr Asn Val Gln Leu Met Ile Leu Ala Ile 
    130                 135                 140                 

Ser Leu Ile Leu Met Ile Leu Leu Gln Val Ile Val Gln Lys Thr Lys 
145                 150                 155                 160 

Met Gly Lys Ala Met Arg Ala Val Ser Val Asp Ser Asp Ala Ala Gln 
                165                 170                 175     

Leu Met Gly Ile Asn Val Asn Arg Thr Ile Ser Phe Thr Phe Ala Leu 
            180                 185                 190         

Gly Ser Ala Leu Ala Gly Ala Ala Gly Val Leu Ile Ala Leu Tyr Tyr 
        195                 200                 205             

Asn Ser Leu Glu Pro Leu Met Gly Val Thr Pro Gly Leu Lys Ser Phe 
    210                 215                 220                 

Val Ala Ala Val Leu Gly Gly Ile Gly Ile Ile Pro Gly Ala Ala Leu 
225                 230                 235                 240 

Gly Gly Phe Val Ile Gly Leu Leu Glu Thr Phe Ala Thr Ala Phe Gly 
                245                 250                 255     

Met Ser Asp Phe Arg Asp Ala Ile Val Tyr Gly Ile Leu Leu Leu Ile 
            260                 265                 270         

Leu Ile Val Arg Pro Ala Gly Ile Leu Gly Lys Asn Val Lys Glu Lys 
        275                 280                 285             

Val 
    

<210>   1421
<211>   954
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1421
atgaaggaaa atttaaaagt taatattcta tggttactcc ttttgttagc tggctatagc   60
ttgattagtg tactggtttc agtcggagta cttaatctat tctatgtaca gattttacaa   120
caaattggaa ttaatattat tttggctgtt ggtctcaact taatcgttgg tttttcagga   180
caattttcac ttggtcatgc tggtttcatg gcgattggtg cctatgcagc agctattatt   240
ggttctaaat caccaaccta cggtgccttc tttggagcta tgcttgtagg ggctttgctt   300
tcaggagcag ttgccttact tgtcggcatt ccaaccttgc gcttgaaggg ggactatctt   360
gcggtagcaa ctctgggtgt ttctgaaatt atccgtatct ttatcatcaa tggtggaagc   420
cttacaaatg gtgcggcagg tatcttaggg attcctaact ttacaacttg gcaaatggtt   480
tacttctttg tcgtgattac aaccattgca accttgaact tcttgcgtag cccaattggt   540
cgttcaaccc tctctgttcg tgaagatgaa atcgctgctg agtcagttgg ggttaatacg   600
actaaaatta aaatcatcgc ttttgtcttt ggtgccatta ctgcaagtat tgctgggtca   660
cttcaggcag gatttatcgg gtctgttgta ccgaaagatt acaccttcat caactcaatc   720
aacgttttga ttattgttgt atttggtgga ctcggttcca ttacaggtgc gattgtttcg   780
gctattgttc tgggaatttt gaatatgctt ctccaagatg ttgctagtgt gcgtatgatt   840
atttacgctt tggccttggt attggtaatg attttcagac caggtggact ccttggaaca   900
tgggaactga gcctatcacg tttctttaaa aaatctaaga aggaggaaca aaac         954

<210>   1422
<211>   318
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   branched-chain amino acid ABC transporter, permease protein (livM)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902705 (e-173)

<400>   1422
Met Lys Glu Asn Leu Lys Val Asn Ile Leu Trp Leu Leu Leu Leu Leu 
1               5                   10                  15      

Ala Gly Tyr Ser Leu Ile Ser Val Leu Val Ser Val Gly Val Leu Asn 
            20                  25                  30          

Leu Phe Tyr Val Gln Ile Leu Gln Gln Ile Gly Ile Asn Ile Ile Leu 
        35                  40                  45              

Ala Val Gly Leu Asn Leu Ile Val Gly Phe Ser Gly Gln Phe Ser Leu 
    50                  55                  60                  

Gly His Ala Gly Phe Met Ala Ile Gly Ala Tyr Ala Ala Ala Ile Ile 
65                  70                  75                  80  

Gly Ser Lys Ser Pro Thr Tyr Gly Ala Phe Phe Gly Ala Met Leu Val 
                85                  90                  95      

Gly Ala Leu Leu Ser Gly Ala Val Ala Leu Leu Val Gly Ile Pro Thr 
            100                 105                 110         

Leu Arg Leu Lys Gly Asp Tyr Leu Ala Val Ala Thr Leu Gly Val Ser 
        115                 120                 125             

Glu Ile Ile Arg Ile Phe Ile Ile Asn Gly Gly Ser Leu Thr Asn Gly 
    130                 135                 140                 

Ala Ala Gly Ile Leu Gly Ile Pro Asn Phe Thr Thr Trp Gln Met Val 
145                 150                 155                 160 

Tyr Phe Phe Val Val Ile Thr Thr Ile Ala Thr Leu Asn Phe Leu Arg 
                165                 170                 175     

Ser Pro Ile Gly Arg Ser Thr Leu Ser Val Arg Glu Asp Glu Ile Ala 
            180                 185                 190         

Ala Glu Ser Val Gly Val Asn Thr Thr Lys Ile Lys Ile Ile Ala Phe 
        195                 200                 205             

Val Phe Gly Ala Ile Thr Ala Ser Ile Ala Gly Ser Leu Gln Ala Gly 
    210                 215                 220                 

Phe Ile Gly Ser Val Val Pro Lys Asp Tyr Thr Phe Ile Asn Ser Ile 
225                 230                 235                 240 

Asn Val Leu Ile Ile Val Val Phe Gly Gly Leu Gly Ser Ile Thr Gly 
                245                 250                 255     

Ala Ile Val Ser Ala Ile Val Leu Gly Ile Leu Asn Met Leu Leu Gln 
            260                 265                 270         

Asp Val Ala Ser Val Arg Met Ile Ile Tyr Ala Leu Ala Leu Val Leu 
        275                 280                 285             

Val Met Ile Phe Arg Pro Gly Gly Leu Leu Gly Thr Trp Glu Leu Ser 
    290                 295                 300                 

Leu Ser Arg Phe Phe Lys Lys Ser Lys Lys Glu Glu Gln Asn 
305                 310                 315             

<210>   1423
<211>   762
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1423
atggcattac ttgaagtaaa acagttaacc aaacattttg gtggtctaac agctgttgga   60
gatgtgactc ttgaattgaa cgaaggggaa ctggttggat taatcggtcc aaacggagct   120
gggaaaacca cccttttcaa ccttttgacc ggtgtttatg aaccaagcga gggaacagta   180
accctagatg gtcacctttt gaatgggaaa tcaccttata agattgcctc tttgggactt   240
ggacgtactt tccaaaatat ccgtctcttt aaagatttaa cagttttaga taatgttttg   300
attgcttttg gaaaccatca caaacagcat gtttttacta gtttcttacg cttaccagct   360
ttttacaaga gtgaaaaaga attaaaggct aaagctttgg aattgttgaa aatctttgat   420
ttagatggtg atgcagagac tcttgctaaa aatctttcct acggacaaca acgtcgtttg   480
gaaattgttc gtgcccttgc tacggaacct aaaattctct tcttagatga accagcagca   540
ggtatgaacc cacaggaaac agccgaattg actgagttaa ttcgtcgtat caaagatgag   600
tttaagatta caatcatgtt gattgaacac gatatgaatc tggtcatgga agtaacagaa   660
cgtatctacg tacttgaata tggccgttta atcgctcaag gaactccaga cgaaattaag   720
accaataaac gcgttatcga agcttatcta ggaggtgaag cc                      762

<210>   1424
<211>   254
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   branched-chain amino acid ABC transporter, ATP-binding protein (livG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902706 (e-142)

<400>   1424
Met Ala Leu Leu Glu Val Lys Gln Leu Thr Lys His Phe Gly Gly Leu 
1               5                   10                  15      

Thr Ala Val Gly Asp Val Thr Leu Glu Leu Asn Glu Gly Glu Leu Val 
            20                  25                  30          

Gly Leu Ile Gly Pro Asn Gly Ala Gly Lys Thr Thr Leu Phe Asn Leu 
        35                  40                  45              

Leu Thr Gly Val Tyr Glu Pro Ser Glu Gly Thr Val Thr Leu Asp Gly 
    50                  55                  60                  

His Leu Leu Asn Gly Lys Ser Pro Tyr Lys Ile Ala Ser Leu Gly Leu 
65                  70                  75                  80  

Gly Arg Thr Phe Gln Asn Ile Arg Leu Phe Lys Asp Leu Thr Val Leu 
                85                  90                  95      

Asp Asn Val Leu Ile Ala Phe Gly Asn His His Lys Gln His Val Phe 
            100                 105                 110         

Thr Ser Phe Leu Arg Leu Pro Ala Phe Tyr Lys Ser Glu Lys Glu Leu 
        115                 120                 125             

Lys Ala Lys Ala Leu Glu Leu Leu Lys Ile Phe Asp Leu Asp Gly Asp 
    130                 135                 140                 

Ala Glu Thr Leu Ala Lys Asn Leu Ser Tyr Gly Gln Gln Arg Arg Leu 
145                 150                 155                 160 

Glu Ile Val Arg Ala Leu Ala Thr Glu Pro Lys Ile Leu Phe Leu Asp 
                165                 170                 175     

Glu Pro Ala Ala Gly Met Asn Pro Gln Glu Thr Ala Glu Leu Thr Glu 
            180                 185                 190         

Leu Ile Arg Arg Ile Lys Asp Glu Phe Lys Ile Thr Ile Met Leu Ile 
        195                 200                 205             

Glu His Asp Met Asn Leu Val Met Glu Val Thr Glu Arg Ile Tyr Val 
    210                 215                 220                 

Leu Glu Tyr Gly Arg Leu Ile Ala Gln Gly Thr Pro Asp Glu Ile Lys 
225                 230                 235                 240 

Thr Asn Lys Arg Val Ile Glu Ala Tyr Leu Gly Gly Glu Ala 
                245                 250                 

<210>   1425
<211>   708
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1425
atgtctatgt taaaagttga aaatctttct gtgcattacg gtatgatcca agcagttcgt   60
gatgtaagct ttgaagttaa tgaaggagaa gttgtttccc ttatcggtgc caacggtgca   120
ggtaagacaa ctattcttcg caccttgtca ggtttggttc gaccaagttc aggaaagatt   180
gaatttttag gtcaagaaat ccaaaaaatg ccagctcaga aaatcgtggc aagtggtctt   240
tcacaagttc cagaaggacg ccacgtcttt cctggcttga ctgttatgga aaatcttgaa   300
atgggagctt tcttaaagaa aaatcgtgaa gaaaatcaag ctaacttgaa gaaggttttc   360
tcacgctttc ctcgtcttga agaacggaag aaccaagatg cagccactct ttcagggggg   420
gaacaacaaa tgcttgccat gggacgcgcc ctcatgtcaa caccaaaact tcttctttta   480
gatgaaccat caatgggact tgccccaatc tttatccaag aaatttttga tatcattcaa   540
gatattcaga agcaaggaac aacggtcctc ttgattgaac aaaatgccaa taaagcactt   600
gcaatctctg accgaggata tgtactggaa acagggagaa tcgtcctatc aggaacagga   660
aaagaactcg cttcatcaga agaagtcaga aaagcatatc taggtggc                708

<210>   1426
<211>   236
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   branched-chain amino acid ABC transporter, ATP-binding protein (livF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902707 (e-127)

<400>   1426
Met Ser Met Leu Lys Val Glu Asn Leu Ser Val His Tyr Gly Met Ile 
1               5                   10                  15      

Gln Ala Val Arg Asp Val Ser Phe Glu Val Asn Glu Gly Glu Val Val 
            20                  25                  30          

Ser Leu Ile Gly Ala Asn Gly Ala Gly Lys Thr Thr Ile Leu Arg Thr 
        35                  40                  45              

Leu Ser Gly Leu Val Arg Pro Ser Ser Gly Lys Ile Glu Phe Leu Gly 
    50                  55                  60                  

Gln Glu Ile Gln Lys Met Pro Ala Gln Lys Ile Val Ala Ser Gly Leu 
65                  70                  75                  80  

Ser Gln Val Pro Glu Gly Arg His Val Phe Pro Gly Leu Thr Val Met 
                85                  90                  95      

Glu Asn Leu Glu Met Gly Ala Phe Leu Lys Lys Asn Arg Glu Glu Asn 
            100                 105                 110         

Gln Ala Asn Leu Lys Lys Val Phe Ser Arg Phe Pro Arg Leu Glu Glu 
        115                 120                 125             

Arg Lys Asn Gln Asp Ala Ala Thr Leu Ser Gly Gly Glu Gln Gln Met 
    130                 135                 140                 

Leu Ala Met Gly Arg Ala Leu Met Ser Thr Pro Lys Leu Leu Leu Leu 
145                 150                 155                 160 

Asp Glu Pro Ser Met Gly Leu Ala Pro Ile Phe Ile Gln Glu Ile Phe 
                165                 170                 175     

Asp Ile Ile Gln Asp Ile Gln Lys Gln Gly Thr Thr Val Leu Leu Ile 
            180                 185                 190         

Glu Gln Asn Ala Asn Lys Ala Leu Ala Ile Ser Asp Arg Gly Tyr Val 
        195                 200                 205             

Leu Glu Thr Gly Arg Ile Val Leu Ser Gly Thr Gly Lys Glu Leu Ala 
    210                 215                 220                 

Ser Ser Glu Glu Val Arg Lys Ala Tyr Leu Gly Gly 
225                 230                 235     

<210>   1427
<211>   654
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1427
atggcagtta aagattttat gacccgcaag gtagtttata ttagtccaga tataacagta   60
tctcatgcag cagatttgat gagagagcaa ggtttgcacc gtctgcctgt tatcgaaaat   120
gatcaattag ttggtttggt gactgaggga accattgcac aagcaagtcc atctaaagca   180
acaagtcttt ctatctatga gatgaattat cttctgaata agacaaaagt aaaagatgtc   240
atgattcgcg atgttgtcac tgtctcaggc tatgctagtc tagaagatgc aacttatctg   300
atgttgaaaa ataagattag tattctccct gtcgtagata accatcaagt atacggagtt   360
attactgacc gtgacgtttt ccaagccttt cttgaaattg caggttatgg cgaagaaggg   420
attcgtgtac gctttgttac agaagatgaa gttggtgttc ttggaaaaat tgtttctttg   480
attgtagaag aaaatttgaa tatctcccat acagtcaata ttccgcgtaa ggatggtaag   540
gtgattatcg aagtgcaaat cgatggatca attgatttac cagccttgaa agaaaaattt   600
gaagcaaatg gtattcaagt ggaagaaatc gctcgcactt cagcaaaagt cttg         654

<210>   1428
<211>   218
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetoin utilization protein AcuB, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902708 (e-116)

<400>   1428
Met Ala Val Lys Asp Phe Met Thr Arg Lys Val Val Tyr Ile Ser Pro 
1               5                   10                  15      

Asp Ile Thr Val Ser His Ala Ala Asp Leu Met Arg Glu Gln Gly Leu 
            20                  25                  30          

His Arg Leu Pro Val Ile Glu Asn Asp Gln Leu Val Gly Leu Val Thr 
        35                  40                  45              

Glu Gly Thr Ile Ala Gln Ala Ser Pro Ser Lys Ala Thr Ser Leu Ser 
    50                  55                  60                  

Ile Tyr Glu Met Asn Tyr Leu Leu Asn Lys Thr Lys Val Lys Asp Val 
65                  70                  75                  80  

Met Ile Arg Asp Val Val Thr Val Ser Gly Tyr Ala Ser Leu Glu Asp 
                85                  90                  95      

Ala Thr Tyr Leu Met Leu Lys Asn Lys Ile Ser Ile Leu Pro Val Val 
            100                 105                 110         

Asp Asn His Gln Val Tyr Gly Val Ile Thr Asp Arg Asp Val Phe Gln 
        115                 120                 125             

Ala Phe Leu Glu Ile Ala Gly Tyr Gly Glu Glu Gly Ile Arg Val Arg 
    130                 135                 140                 

Phe Val Thr Glu Asp Glu Val Gly Val Leu Gly Lys Ile Val Ser Leu 
145                 150                 155                 160 

Ile Val Glu Glu Asn Leu Asn Ile Ser His Thr Val Asn Ile Pro Arg 
                165                 170                 175     

Lys Asp Gly Lys Val Ile Ile Glu Val Gln Ile Asp Gly Ser Ile Asp 
            180                 185                 190         

Leu Pro Ala Leu Lys Glu Lys Phe Glu Ala Asn Gly Ile Gln Val Glu 
        195                 200                 205             

Glu Ile Ala Arg Thr Ser Ala Lys Val Leu 
    210                 215             

<210>   1429
<211>   987
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1429
ttggaaaaca agatgacaga acctgatttt tggaacgata atattgcggc ccaaaaaacg   60
tcgcaagaat taaatgaatt aaaaaacact tacaatacct tccataagat ggaagagttg   120
caggatgaag tcgaaatttt attggatttt ttggctgaag acgagtcagt gcatgatgaa   180
ctggtagcgc agttagccga acttgataag ataatgacca gctacgagat gactctactc   240
ttgtcagaac cttatgacca caacaatgcc atcttggaaa tccatccagg ttctggtggt   300
actgaggcgc aggactgggg tgatatgttg cttcgtatgt atactcgtta tggtaatgct   360
aaaggcttta aagtggaagt gttggattac caagcaggtg atgaggctgg tattaagtcg   420
gtaactttat catttgaagg gcctaatgcc tatggtctcc tcaagtcaga aatgggtgtt   480
caccgcttag tgcgaatctc accatttgac tctgccaaac gtcgccatac ctctttcaca   540
tctgtagaag tgatgccaga attggatgat actattgaag tggaaatccg tgaagatgat   600
atcaagatgg ataccttccg ttcaggtggt gccggtggac aaaacgtcaa taaggtttca   660
acaggtgtac gtttaaccca cattccaact ggaattgttg tccaatcaac agtagatcgt   720
acccagtatg gaaatagaga tcgtgccatg aagatgttgc aggctaagct ctatcaaatg   780
gagcaagata agaaggctgc ggaggtagat tctctcaaag gtgagaaaaa ggagatcact   840
tggggaagcc aaatccgttc ttatgtcttc acgccttata ctatggtaaa agatcaccga   900
actagctttg aggttgctca ggtagataag gttatggatg gggacctaga tggttttatc   960
gatgcttatc tcaagtggcg aattagc                                       987

<210>   1430
<211>   329
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptide chain release factor 2, FRAMESHIFT (prfB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902709 (0.E+01)

<400>   1430
Met Glu Asn Lys Met Thr Glu Pro Asp Phe Trp Asn Asp Asn Ile Ala 

1               5                   10                  15      

Ala Gln Lys Thr Ser Gln Glu Leu Asn Glu Leu Lys Asn Thr Tyr Asn 
            20                  25                  30          

Thr Phe His Lys Met Glu Glu Leu Gln Asp Glu Val Glu Ile Leu Leu 
        35                  40                  45              

Asp Phe Leu Ala Glu Asp Glu Ser Val His Asp Glu Leu Val Ala Gln 
    50                  55                  60                  

Leu Ala Glu Leu Asp Lys Ile Met Thr Ser Tyr Glu Met Thr Leu Leu 
65                  70                  75                  80  

Leu Ser Glu Pro Tyr Asp His Asn Asn Ala Ile Leu Glu Ile His Pro 
                85                  90                  95      

Gly Ser Gly Gly Thr Glu Ala Gln Asp Trp Gly Asp Met Leu Leu Arg 
            100                 105                 110         

Met Tyr Thr Arg Tyr Gly Asn Ala Lys Gly Phe Lys Val Glu Val Leu 
        115                 120                 125             

Asp Tyr Gln Ala Gly Asp Glu Ala Gly Ile Lys Ser Val Thr Leu Ser 
    130                 135                 140                 

Phe Glu Gly Pro Asn Ala Tyr Gly Leu Leu Lys Ser Glu Met Gly Val 
145                 150                 155                 160 

His Arg Leu Val Arg Ile Ser Pro Phe Asp Ser Ala Lys Arg Arg His 
                165                 170                 175     

Thr Ser Phe Thr Ser Val Glu Val Met Pro Glu Leu Asp Asp Thr Ile 
            180                 185                 190         

Glu Val Glu Ile Arg Glu Asp Asp Ile Lys Met Asp Thr Phe Arg Ser 
        195                 200                 205             

Gly Gly Ala Gly Gly Gln Asn Val Asn Lys Val Ser Thr Gly Val Arg 
    210                 215                 220                 

Leu Thr His Ile Pro Thr Gly Ile Val Val Gln Ser Thr Val Asp Arg 
225                 230                 235                 240 

Thr Gln Tyr Gly Asn Arg Asp Arg Ala Met Lys Met Leu Gln Ala Lys 
                245                 250                 255     

Leu Tyr Gln Met Glu Gln Asp Lys Lys Ala Ala Glu Val Asp Ser Leu 
            260                 265                 270         

Lys Gly Glu Lys Lys Glu Ile Thr Trp Gly Ser Gln Ile Arg Ser Tyr 
        275                 280                 285             

Val Phe Thr Pro Tyr Thr Met Val Lys Asp His Arg Thr Ser Phe Glu 
    290                 295                 300                 

Val Ala Gln Val Asp Lys Val Met Asp Gly Asp Leu Asp Gly Phe Ile 
305                 310                 315                 320 

Asp Ala Tyr Leu Lys Trp Arg Ile Ser 
                325                 

<210>   1431
<211>   690
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1431
atgtcaatta ttgaaatgag agatgtcgtt aaaaaatacg acaacggaac aactgctcta   60
cgcggtgttt cggttagcgt tcaaccgggg gaatttgctt acatcgtagg accttcagga   120
gcagggaagt caacttttat tcgttctctg tatcgtgaag taaaaatcga taaaggaagc   180
ctatcagttg ctggttttaa tctggttaag atcaaaaaga aagatgtccc gcttctacgt   240
cgtagtgttg gggttgtctt ccaggattat aaattgttac caaagaaaac tgtctatgaa   300
aatattgctt acgctatgga agtaatcggg gaaaatcgcc gtaatatcaa aagacgagtg   360
atggaagttt tggacttggt tggattgaag cataaggttc gttctttccc aaatgaactc   420
tcaggtgggg agcaacagcg gattgcgatt gcgcgtgcaa ttgtaaataa tcccaaagta   480
ttgatagctg atgagccaac aggaaatctg gatccggata attcatggga aattatgaat   540
ctcttggaac ggattaacct acaaggaaca actattttga tggcgactca taatagccag   600
attgtaaata ccttgcgcca ccgtgtcatt gccattgaaa atggccgtgt cgttcgtgac   660

gaatcaaaag gagagtatgg atacgatgat                                    690

<210>   1432
<211>   230
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell division ABC transporter, ATP-binding protein FtsE (ftsE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902710 (e-128)

<400>   1432
Met Ser Ile Ile Glu Met Arg Asp Val Val Lys Lys Tyr Asp Asn Gly 
1               5                   10                  15      

Thr Thr Ala Leu Arg Gly Val Ser Val Ser Val Gln Pro Gly Glu Phe 
            20                  25                  30          


Ala Tyr Ile Val Gly Pro Ser Gly Ala Gly Lys Ser Thr Phe Ile Arg 
        35                  40                  45              

Ser Leu Tyr Arg Glu Val Lys Ile Asp Lys Gly Ser Leu Ser Val Ala 
    50                  55                  60                  

Gly Phe Asn Leu Val Lys Ile Lys Lys Lys Asp Val Pro Leu Leu Arg 
65                  70                  75                  80  

Arg Ser Val Gly Val Val Phe Gln Asp Tyr Lys Leu Leu Pro Lys Lys 
                85                  90                  95      

Thr Val Tyr Glu Asn Ile Ala Tyr Ala Met Glu Val Ile Gly Glu Asn 
            100                 105                 110         

Arg Arg Asn Ile Lys Arg Arg Val Met Glu Val Leu Asp Leu Val Gly 
        115                 120                 125             

Leu Lys His Lys Val Arg Ser Phe Pro Asn Glu Leu Ser Gly Gly Glu 
    130                 135                 140                 

Gln Gln Arg Ile Ala Ile Ala Arg Ala Ile Val Asn Asn Pro Lys Val 
145                 150                 155                 160 

Leu Ile Ala Asp Glu Pro Thr Gly Asn Leu Asp Pro Asp Asn Ser Trp 
                165                 170                 175     

Glu Ile Met Asn Leu Leu Glu Arg Ile Asn Leu Gln Gly Thr Thr Ile 
            180                 185                 190         

Leu Met Ala Thr His Asn Ser Gln Ile Val Asn Thr Leu Arg His Arg 
        195                 200                 205             

Val Ile Ala Ile Glu Asn Gly Arg Val Val Arg Asp Glu Ser Lys Gly 
    210                 215                 220                 

Glu Tyr Gly Tyr Asp Asp 
225                 230 

<210>   1433
<211>   987
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1433
gtgtcattgc cattgaaaat ggccgtgtcg ttcgtgacga atcaaaagga gagtatggat   60
acgatgatta gtagattttt tcgccattta tttgaagcct taaaaagttt gaaacgaaat   120
ggttggatga cagtagctgc tgtcagttca gtcatgatta ctttgacctt ggtggcaata   180
tttgcatctg ttattttcaa tacagcgaaa ctagctacag atattgaaaa taatgtccgt   240
gtagtagttt atatccgaaa ggatgtggaa gataatagtc agacaattga aaaagaaggt   300
caaactgtta caaataatga ctaccacaag gtatatgatt ctttgaagaa catgtctacg   360
gttaaaagtg ttaccttttc aagtaaagaa gaacaatatg aaaaattaac cgagataatg   420
ggagataact ggaaaatctt tgaaggagat gccaatcctc tctatgatgc ctatattgta   480
gaggcaaaca ctccaaatga tgtaaaaact atagccgaag atgctaaaaa aattgaaggt   540
gtctctgagg ttcaagatgg cggtgccaat acagaaagac tcttcaagtt agcttcattt   600
atccgtgttt ggggactagg gattgctgct ttgttaattt ttatcgcagt tttcttgatt   660
tcaaatacca ttcgtattac cattatttcc cgcagtcgcg aaattcaaat catgcgcttg   720
gtcggagcta aaaacagtta tatccgtgga ccgttcttgt tagaaggagc ctttatcggt   780
ttattgggag ctatcgcacc atctgttttg gtctttattg tttatcaaat tgtttaccaa   840
tctgtcaaca aatcgttggt agggcaaaat ctatccatga ttagtccaga tttatttagt   900
ccgttgatga ttgccctact atttgtgatt ggggttttca ttggttcatt gggatcagga   960
atatccatgc gccgattctt gaagatt                                       987

<210>   1434
<211>   329
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   cell division ABC transporter, permease protein FtsX (ftsX)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902711 (e-169)

<400>   1434
Met Ser Leu Pro Leu Lys Met Ala Val Ser Phe Val Thr Asn Gln Lys 
1               5                   10                  15      

Glu Ser Met Asp Thr Met Ile Ser Arg Phe Phe Arg His Leu Phe Glu 
            20                  25                  30          

Ala Leu Lys Ser Leu Lys Arg Asn Gly Trp Met Thr Val Ala Ala Val 
        35                  40                  45              

Ser Ser Val Met Ile Thr Leu Thr Leu Val Ala Ile Phe Ala Ser Val 
    50                  55                  60                  

Ile Phe Asn Thr Ala Lys Leu Ala Thr Asp Ile Glu Asn Asn Val Arg 
65                  70                  75                  80  

Val Val Val Tyr Ile Arg Lys Asp Val Glu Asp Asn Ser Gln Thr Ile 
                85                  90                  95      

Glu Lys Glu Gly Gln Thr Val Thr Asn Asn Asp Tyr His Lys Val Tyr 
            100                 105                 110         

Asp Ser Leu Lys Asn Met Ser Thr Val Lys Ser Val Thr Phe Ser Ser 
        115                 120                 125             

Lys Glu Glu Gln Tyr Glu Lys Leu Thr Glu Ile Met Gly Asp Asn Trp 
    130                 135                 140                 

Lys Ile Phe Glu Gly Asp Ala Asn Pro Leu Tyr Asp Ala Tyr Ile Val 
145                 150                 155                 160 

Glu Ala Asn Thr Pro Asn Asp Val Lys Thr Ile Ala Glu Asp Ala Lys 
                165                 170                 175     

Lys Ile Glu Gly Val Ser Glu Val Gln Asp Gly Gly Ala Asn Thr Glu 
            180                 185                 190         

Arg Leu Phe Lys Leu Ala Ser Phe Ile Arg Val Trp Gly Leu Gly Ile 
        195                 200                 205             

Ala Ala Leu Leu Ile Phe Ile Ala Val Phe Leu Ile Ser Asn Thr Ile 
    210                 215                 220                 

Arg Ile Thr Ile Ile Ser Arg Ser Arg Glu Ile Gln Ile Met Arg Leu 
225                 230                 235                 240 

Val Gly Ala Lys Asn Ser Tyr Ile Arg Gly Pro Phe Leu Leu Glu Gly 
                245                 250                 255     

Ala Phe Ile Gly Leu Leu Gly Ala Ile Ala Pro Ser Val Leu Val Phe 
            260                 265                 270         

Ile Val Tyr Gln Ile Val Tyr Gln Ser Val Asn Lys Ser Leu Val Gly 
        275                 280                 285             

Gln Asn Leu Ser Met Ile Ser Pro Asp Leu Phe Ser Pro Leu Met Ile 
    290                 295                 300                 

Ala Leu Leu Phe Val Ile Gly Val Phe Ile Gly Ser Leu Gly Ser Gly 
305                 310                 315                 320 

Ile Ser Met Arg Arg Phe Leu Lys Ile 
                325                 

<210>   1435
<211>   2178
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1435
atgatgaaag atacattcaa aaatgtcttg tctttcgaat tttggcaaaa attcggtaag   60
gctttgatgg tagttatcgc ggttatgccg gctgctggtt tgatgatttc aatcggtaag   120
tctatcgtga tgattaaccc aacctttgca ccacttgtca tcacaggtgg aattcttgag   180
caaatcggtt ggggggttat cggtaacctt cacattttgt ttgccctagc cattggagga   240
agctgggcta aagaacgtgc tggtggtgct ttcgccgctg gtcttgcctt catcttgatt   300
aaccgtatca ctggtacaat ctttggtgta tcaggcgata tgttgaaaaa tccagatgct   360
atggtaacta ctttctttgg tggttcaatc aaagttgctg attactttat cagtgttctt   420
gaagctccag ccttgaacat gggggtattc gtagggatta tctcaggttt tgtaggggca   480
actgcttaca acaaatacta caacttccgt aaacttcctg atgcactttc attcttcaac   540
gggaaacgtt tcgtaccatt tgtagttatt cttcgttcag caatcgctgc aattctactt   600
gctgctttct ggccagtagt tcaaacaggt atcaataact tcggtatctg gattgccaac   660
tcacaagaaa ctgctccaat tcttgcacca ttcttgtatg gtactttgga acgtttgctc   720
ttgccatttg gtcttcacca catgttgact atcccaatga actacacagc tcttggtggt   780
acttatgaca ttttaactgg tgcagctaaa ggtactcaag tattcggtca agacccacta   840
tggcttgcat gggtaacaga ccttgtaaac cttaaaggta ctgatgctag tcaatatcaa   900
cacttgttag atacagtaca tccagctcgt ttcaaagttg gacaaatgat cggttcattc   960
ggtatcttga tgggtgtgat tgttgctatc taccgtaatg ttgatgctga caagaaacat   1020
aaatacaaag gtatgatgat tgcaacagct cttgcaacat tcttgacagg ggttactgaa   1080
ccaatcgaat acatgttcat gttcatcgca acacctatgt atcttgttta ctcacttgtt   1140
caaggtgctg ccttcgctat ggctgacgtc gtaaacctac gtatgcactc attcggttca   1200
atcgagttct tgactcgtac acctattgca atcagtgctg gtattggtat ggatatcgtt   1260
aacttcgttt gggtaactgt tctctttgct gtaatcatgt actttatcgc aaacttcatg   1320
attcaaaaat tcaactacgc aactccaggg cgcaacggaa actacgaaac tgctgaaggt   1380
tcagaagaaa ccagcagcga agtgaaagtt gcagcaggct ctcaagctgt aaacattatc   1440
aaccttcttg gtggacgtgt aaacatcgtt gatgttgatg catgtatgac tcgtcttcgt   1500
gtaactgtta aagatgcaga taaagtagga aatgcagagc aatggaaagc agaaggagct   1560
atgggtcttg tcatgaaagg acaaggggtt caagctatct acggtccaaa agctgacatt   1620
ttgaaatctg atatccaaga tatccttgat tcaggtgaaa tcattcctga aactcttcca   1680
agccaaatga ctgaagcaca acaaaacact gttcacttca aagatcttac tgaggaagtt   1740
tactcagtag cagacggtca agttgttgct ttggaacaag taaaggatcc agtatttgct   1800
caaaaaatga tgggtgatgg atttgcagta gaacctgcaa atggaaacat tgtatctcca   1860
gtttcaggta ctgtgtcaag catcttccca acaaaacatg cttttggtat tgtgacggaa   1920
gcaggtcttg aagtattggt tcacattggt ttggacacag taagtcttga aggtaaacca   1980
tttacagttc atgttgctga aggacaaaaa gttgcagcag gagatctcct tgtcacagct   2040
gacttggatg ctatccgtgc agcaggacgt gaaacttcaa cagtagttgt cttcacaaat   2100
ggtgatgcaa ttaaatcagt taagttagaa aaaacaggtt ctcttgcagc taaaacagca   2160
gttgctaaag tagaattg                                                 2178

<210>   1436
<211>   726
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIABC components
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902712 (0.E+01)

<400>   1436
Met Met Lys Asp Thr Phe Lys Asn Val Leu Ser Phe Glu Phe Trp Gln 
1               5                   10                  15      

Lys Phe Gly Lys Ala Leu Met Val Val Ile Ala Val Met Pro Ala Ala 
            20                  25                  30          

Gly Leu Met Ile Ser Ile Gly Lys Ser Ile Val Met Ile Asn Pro Thr 
        35                  40                  45              

Phe Ala Pro Leu Val Ile Thr Gly Gly Ile Leu Glu Gln Ile Gly Trp 
    50                  55                  60                  

Gly Val Ile Gly Asn Leu His Ile Leu Phe Ala Leu Ala Ile Gly Gly 
65                  70                  75                  80  

Ser Trp Ala Lys Glu Arg Ala Gly Gly Ala Phe Ala Ala Gly Leu Ala 
                85                  90                  95      

Phe Ile Leu Ile Asn Arg Ile Thr Gly Thr Ile Phe Gly Val Ser Gly 
            100                 105                 110         

Asp Met Leu Lys Asn Pro Asp Ala Met Val Thr Thr Phe Phe Gly Gly 
        115                 120                 125             

Ser Ile Lys Val Ala Asp Tyr Phe Ile Ser Val Leu Glu Ala Pro Ala 
    130                 135                 140                 

Leu Asn Met Gly Val Phe Val Gly Ile Ile Ser Gly Phe Val Gly Ala 
145                 150                 155                 160 

Thr Ala Tyr Asn Lys Tyr Tyr Asn Phe Arg Lys Leu Pro Asp Ala Leu 
                165                 170                 175     

Ser Phe Phe Asn Gly Lys Arg Phe Val Pro Phe Val Val Ile Leu Arg 
            180                 185                 190         

Ser Ala Ile Ala Ala Ile Leu Leu Ala Ala Phe Trp Pro Val Val Gln 
        195                 200                 205             

Thr Gly Ile Asn Asn Phe Gly Ile Trp Ile Ala Asn Ser Gln Glu Thr 
    210                 215                 220                 

Ala Pro Ile Leu Ala Pro Phe Leu Tyr Gly Thr Leu Glu Arg Leu Leu 
225                 230                 235                 240 

Leu Pro Phe Gly Leu His His Met Leu Thr Ile Pro Met Asn Tyr Thr 
                245                 250                 255     

Ala Leu Gly Gly Thr Tyr Asp Ile Leu Thr Gly Ala Ala Lys Gly Thr 
            260                 265                 270         

Gln Val Phe Gly Gln Asp Pro Leu Trp Leu Ala Trp Val Thr Asp Leu 
        275                 280                 285             

Val Asn Leu Lys Gly Thr Asp Ala Ser Gln Tyr Gln His Leu Leu Asp 
    290                 295                 300                 

Thr Val His Pro Ala Arg Phe Lys Val Gly Gln Met Ile Gly Ser Phe 
305                 310                 315                 320 

Gly Ile Leu Met Gly Val Ile Val Ala Ile Tyr Arg Asn Val Asp Ala 
                325                 330                 335     

Asp Lys Lys His Lys Tyr Lys Gly Met Met Ile Ala Thr Ala Leu Ala 
            340                 345                 350         

Thr Phe Leu Thr Gly Val Thr Glu Pro Ile Glu Tyr Met Phe Met Phe 
        355                 360                 365             

Ile Ala Thr Pro Met Tyr Leu Val Tyr Ser Leu Val Gln Gly Ala Ala 
    370                 375                 380                 

Phe Ala Met Ala Asp Val Val Asn Leu Arg Met His Ser Phe Gly Ser 
385                 390                 395                 400 

Ile Glu Phe Leu Thr Arg Thr Pro Ile Ala Ile Ser Ala Gly Ile Gly 
                405                 410                 415     

Met Asp Ile Val Asn Phe Val Trp Val Thr Val Leu Phe Ala Val Ile 
            420                 425                 430         

Met Tyr Phe Ile Ala Asn Phe Met Ile Gln Lys Phe Asn Tyr Ala Thr 
        435                 440                 445             

Pro Gly Arg Asn Gly Asn Tyr Glu Thr Ala Glu Gly Ser Glu Glu Thr 
    450                 455                 460                 

Ser Ser Glu Val Lys Val Ala Ala Gly Ser Gln Ala Val Asn Ile Ile 
465                 470                 475                 480 

Asn Leu Leu Gly Gly Arg Val Asn Ile Val Asp Val Asp Ala Cys Met 
                485                 490                 495     

Thr Arg Leu Arg Val Thr Val Lys Asp Ala Asp Lys Val Gly Asn Ala 
            500                 505                 510         

Glu Gln Trp Lys Ala Glu Gly Ala Met Gly Leu Val Met Lys Gly Gln 
        515                 520                 525             

Gly Val Gln Ala Ile Tyr Gly Pro Lys Ala Asp Ile Leu Lys Ser Asp 
    530                 535                 540                 

Ile Gln Asp Ile Leu Asp Ser Gly Glu Ile Ile Pro Glu Thr Leu Pro 
545                 550                 555                 560 

Ser Gln Met Thr Glu Ala Gln Gln Asn Thr Val His Phe Lys Asp Leu 
                565                 570                 575     

Thr Glu Glu Val Tyr Ser Val Ala Asp Gly Gln Val Val Ala Leu Glu 
            580                 585                 590         

Gln Val Lys Asp Pro Val Phe Ala Gln Lys Met Met Gly Asp Gly Phe 
        595                 600                 605             

Ala Val Glu Pro Ala Asn Gly Asn Ile Val Ser Pro Val Ser Gly Thr 
    610                 615                 620                 

Val Ser Ser Ile Phe Pro Thr Lys His Ala Phe Gly Ile Val Thr Glu 
625                 630                 635                 640 

Ala Gly Leu Glu Val Leu Val His Ile Gly Leu Asp Thr Val Ser Leu 
                645                 650                 655     

Glu Gly Lys Pro Phe Thr Val His Val Ala Glu Gly Gln Lys Val Ala 
            660                 665                 670         

Ala Gly Asp Leu Leu Val Thr Ala Asp Leu Asp Ala Ile Arg Ala Ala 
        675                 680                 685             

Gly Arg Glu Thr Ser Thr Val Val Val Phe Thr Asn Gly Asp Ala Ile 
    690                 695                 700                 

Lys Ser Val Lys Leu Glu Lys Thr Gly Ser Leu Ala Ala Lys Thr Ala 
705                 710                 715                 720 

Val Ala Lys Val Glu Leu 
                725     

<210>   1437
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1437
ttgaggttgg aagctgtatt ccaacctctt attttgggag aaaagaatga aatttttaac   60
actcaatact cacagttgga tggagaaaga agcagaggaa aaattccaga ttttgct      117

<210>   1438
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1438
Met Arg Leu Glu Ala Val Phe Gln Pro Leu Ile Leu Gly Glu Lys Asn 
1               5                   10                  15      

Glu Ile Phe Asn Thr Gln Tyr Ser Gln Leu Asp Gly Glu Arg Ser Arg 
            20                  25                  30          

Gly Lys Ile Pro Asp Phe Ala 
        35                  

<210>   1439
<211>   684
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1439
atgacctcgt cagaggtgga ggttaatgac ctttatcaag ctttgccagc agctgagcct   60
attcaccaag accattatgt tagactcttg gttgaaaagt tgtctgagca agggaaaaat   120
tactactgga cctgggccta taaccatatc ggctataacc gctaccacga aggtgtggct   180
atcttgtcta aaacacctat tgaagccaga gaaattttgg tttcagatgt ggatgatcca   240
acagactatc atactcgccg tgttgcccta gctgaaactg tagtcgatgg caaggagcta   300
gcagttgcca gtgttcatct ctcttggtgg gataaaggtt tccaagaaga atgggcacga   360
tttgaggctg tcttgaaaaa attgaacaag ccacttttac tagctggaga tttcaacaat   420
ccggctggac aggaaggtta ccaagctatt ttagctagtc cattaggctt acaagacgca   480
tttgaagttg ctcaagagaa aagtggtagc tatactgttc cgcctgaaat tgatggctgg   540
aaagggaaca ctgaacccct tcgaatcgat tatgtcttta ctaccaaaga gttagcggtg   600
gaaaatttac atgtcgtatt tgatggtaac aagagtccac aagtgagtga tcactatggc   660
ttgaatgcta tattaaactg gaaa                                          684

<210>   1440
<211>   228
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902713 (e-133)

<400>   1440
Met Thr Ser Ser Glu Val Glu Val Asn Asp Leu Tyr Gln Ala Leu Pro 
1               5                   10                  15      

Ala Ala Glu Pro Ile His Gln Asp His Tyr Val Arg Leu Leu Val Glu 
            20                  25                  30          

Lys Leu Ser Glu Gln Gly Lys Asn Tyr Tyr Trp Thr Trp Ala Tyr Asn 
        35                  40                  45              

His Ile Gly Tyr Asn Arg Tyr His Glu Gly Val Ala Ile Leu Ser Lys 
    50                  55                  60                  

Thr Pro Ile Glu Ala Arg Glu Ile Leu Val Ser Asp Val Asp Asp Pro 
65                  70                  75                  80  

Thr Asp Tyr His Thr Arg Arg Val Ala Leu Ala Glu Thr Val Val Asp 
                85                  90                  95      

Gly Lys Glu Leu Ala Val Ala Ser Val His Leu Ser Trp Trp Asp Lys 
            100                 105                 110         

Gly Phe Gln Glu Glu Trp Ala Arg Phe Glu Ala Val Leu Lys Lys Leu 
        115                 120                 125             

Asn Lys Pro Leu Leu Leu Ala Gly Asp Phe Asn Asn Pro Ala Gly Gln 
    130                 135                 140                 

Glu Gly Tyr Gln Ala Ile Leu Ala Ser Pro Leu Gly Leu Gln Asp Ala 
145                 150                 155                 160 

Phe Glu Val Ala Gln Glu Lys Ser Gly Ser Tyr Thr Val Pro Pro Glu 
                165                 170                 175     

Ile Asp Gly Trp Lys Gly Asn Thr Glu Pro Leu Arg Ile Asp Tyr Val 
            180                 185                 190         

Phe Thr Thr Lys Glu Leu Ala Val Glu Asn Leu His Val Val Phe Asp 
        195                 200                 205             

Gly Asn Lys Ser Pro Gln Val Ser Asp His Tyr Gly Leu Asn Ala Ile 
    210                 215                 220                 

Leu Asn Trp Lys 
225             

<210>   1441
<211>   1341
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1441
atgtcattta cgaaatttca atttaaaaac tatattagag aagccttgaa ggagttaaaa   60
tttacaactc caacagaggt gcaagacaag ttgattccta ttgttttggc aggtcgtgac   120
ctagtaggag aatcaaaaac aggttcaggt aagactcata ctttcttgtt accgattttc   180
cagcaattag atgaagctag cgatagtgta caagcagtga ttactgcacc gagtcgtgag   240
ttggctactc aaatttacca agtagcgcgt cagatttcag ctcactcaga tgtcgaagtt   300
cgtgtggtta attatgtggg tggtacggat aaggctcgcc agattgagaa attggcaagc   360
aatcagcctc atattgttat tggaacacca ggccgtatct acgacttggt taaatctggt   420
gatttagcta ttcataaagc caagacattt gttgttgatg aagcagatat gaccttggat   480
atgggattct tggaaactgt tgataagatt gctggcagtc ttccaaaaga cttgcaattc   540
atggtcttct cagcgactat cccacaaaaa ctgcaaccat tcttgaaaaa atacttatca   600
aatcctgtta tggagaaaat taagaccaaa acggttattt ctgacaccat tgataattgg   660
ttgatttcga ccaagggaca tgataagaat gctcaaattt accagttgac tcagttgatg   720
cagccgtatt tggcaatgat ttttgttaac actaaaacgc gtgctgatga attgcattca   780
tatctgactg ctcaaggctt gaaggttgca aaaatccatg gcgatattgc ccctcgtgaa   840
cgcaagcgaa tcatgaatca ggtgcaaaat ctggattttg agtatattgt cgcaacagat   900
ttggcagcgc gtgggattga cattgaaggt gtcagccatg tcatcaatga tgccattccg   960
caagacttat ctttttttgt tcatcgtgtt ggtcgtactg gacgaaatgg cctaccaggt   1020
acagctatta ccctttatca gccaagtgat gactcggata tccgtgagtt ggagaaattg   1080
ggaatcaagt ttagtcctaa gatggtcaaa gacggggaat ttcaagatac ctatgaccgt   1140
gatcgtcgtg ccaaccgtga gaaaaaacaa gataaacttg atatcgaaat gattggtttg   1200
gttaaaaaga aaaagaaaaa agtcaaaccg ggttataaga agaaaattca atgggcggtt   1260
gatgaaaagc gccgtaaaac caagcgtgct gaaaatcgcg ctcgcggtcg tgcagagcgt   1320
aaagctaaac gccaaacatt t                                             1341

<210>   1442
<211>   447
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent RNA helicase, DEAD/DEAH box family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902714 (0.E+01)

<400>   1442
Met Ser Phe Thr Lys Phe Gln Phe Lys Asn Tyr Ile Arg Glu Ala Leu 
1               5                   10                  15      

Lys Glu Leu Lys Phe Thr Thr Pro Thr Glu Val Gln Asp Lys Leu Ile 
            20                  25                  30          

Pro Ile Val Leu Ala Gly Arg Asp Leu Val Gly Glu Ser Lys Thr Gly 
        35                  40                  45              

Ser Gly Lys Thr His Thr Phe Leu Leu Pro Ile Phe Gln Gln Leu Asp 
    50                  55                  60                  

Glu Ala Ser Asp Ser Val Gln Ala Val Ile Thr Ala Pro Ser Arg Glu 
65                  70                  75                  80  

Leu Ala Thr Gln Ile Tyr Gln Val Ala Arg Gln Ile Ser Ala His Ser 
                85                  90                  95      

Asp Val Glu Val Arg Val Val Asn Tyr Val Gly Gly Thr Asp Lys Ala 
            100                 105                 110         

Arg Gln Ile Glu Lys Leu Ala Ser Asn Gln Pro His Ile Val Ile Gly 
        115                 120                 125             

Thr Pro Gly Arg Ile Tyr Asp Leu Val Lys Ser Gly Asp Leu Ala Ile 
    130                 135                 140                 

His Lys Ala Lys Thr Phe Val Val Asp Glu Ala Asp Met Thr Leu Asp 
145                 150                 155                 160 

Met Gly Phe Leu Glu Thr Val Asp Lys Ile Ala Gly Ser Leu Pro Lys 
                165                 170                 175     

Asp Leu Gln Phe Met Val Phe Ser Ala Thr Ile Pro Gln Lys Leu Gln 
            180                 185                 190         

Pro Phe Leu Lys Lys Tyr Leu Ser Asn Pro Val Met Glu Lys Ile Lys 
        195                 200                 205             

Thr Lys Thr Val Ile Ser Asp Thr Ile Asp Asn Trp Leu Ile Ser Thr 
    210                 215                 220                 

Lys Gly His Asp Lys Asn Ala Gln Ile Tyr Gln Leu Thr Gln Leu Met 
225                 230                 235                 240 

Gln Pro Tyr Leu Ala Met Ile Phe Val Asn Thr Lys Thr Arg Ala Asp 
                245                 250                 255     

Glu Leu His Ser Tyr Leu Thr Ala Gln Gly Leu Lys Val Ala Lys Ile 
            260                 265                 270         

His Gly Asp Ile Ala Pro Arg Glu Arg Lys Arg Ile Met Asn Gln Val 
        275                 280                 285             

Gln Asn Leu Asp Phe Glu Tyr Ile Val Ala Thr Asp Leu Ala Ala Arg 
    290                 295                 300                 

Gly Ile Asp Ile Glu Gly Val Ser His Val Ile Asn Asp Ala Ile Pro 
305                 310                 315                 320 

Gln Asp Leu Ser Phe Phe Val His Arg Val Gly Arg Thr Gly Arg Asn 
                325                 330                 335     

Gly Leu Pro Gly Thr Ala Ile Thr Leu Tyr Gln Pro Ser Asp Asp Ser 
            340                 345                 350         

Asp Ile Arg Glu Leu Glu Lys Leu Gly Ile Lys Phe Ser Pro Lys Met 
        355                 360                 365             

Val Lys Asp Gly Glu Phe Gln Asp Thr Tyr Asp Arg Asp Arg Arg Ala 
    370                 375                 380                 

Asn Arg Glu Lys Lys Gln Asp Lys Leu Asp Ile Glu Met Ile Gly Leu 
385                 390                 395                 400 

Val Lys Lys Lys Lys Lys Lys Val Lys Pro Gly Tyr Lys Lys Lys Ile 
                405                 410                 415     

Gln Trp Ala Val Asp Glu Lys Arg Arg Lys Thr Lys Arg Ala Glu Asn 
            420                 425                 430         

Arg Ala Arg Gly Arg Ala Glu Arg Lys Ala Lys Arg Gln Thr Phe 
        435                 440                 445         

<210>   1443
<211>   1188
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1443
atgtcagagc gtaaattatt cacgtctgaa tctgtatctg aggggcatcc ggataagatt   60
gcagaccaaa tttcagatgc gattttggat gctattttag caaaggatcc agaggcgcac   120
gttgctgctg aaacagctgt atatactggt tctgtccacg tttttggtga aatttctaca   180
aatgcctatg tggatattaa ccgtgtggtt cgtgatacca ttgcagagat tggttatacc   240
aatacagaat atggattttc tgctgagacg gtgggagtac acccatcttt ggtggaacaa   300
tctcctgaca tcgctcaagg tgttaacgaa gccttggagg ttcgtggaaa tgctgatcaa   360
gatccactgg acttgattgg agcaggtgac caagggctca tgtttggatt tgcagtagat   420
gaaacagaag agcttatgcc attgccaatt gcactcagtc ataaattggt tcgtcgtctg   480
gcagaacttc gtaagtctgg agaaattagc tatctccgtc cagatgcaaa atcacaagtt   540

acagttgagt acgatgaaaa tgaccgtccg gtacgtgtag atacagtcgt tatttctact   600
cagcatgatc cagaggccac taatgaacaa atccatcaag atgtgattga caaggtcatc   660
aaagaagtta ttccatcttc ttatcttgat gataagacaa aattctttat caatccgaca   720
ggtcgttttg taatcggtgg tcctcaaggg gactcaggtt tgactggtcg taagattatt   780
gtagatactt atggtggcta ctctcgtcat ggtggtggtg ccttctctgg taaagatgcg   840
actaaggtgg atcgttcagc ctcttatgcg gctcgctata ttgccaagaa tatcgttgca   900
gcagaccttg ctaagaaggc agaagtgcag ttggcctatg ctatcggtgt tgcgcaacct   960
gtttctgttc gtatcgatac tttcggtaca ggaacagtag ctgaaagtca acttgaaaaa   1020
gcggctcgtc aaatctttga ccttcgccct gcagggatta tccaaatgct ggacctcaag   1080
cgtccaattt accgtcaaac atcggcttac ggtcacatgg gacgtacaga tattgatctt   1140
ccatgggaac gtttggataa ggtagatgct ttgaaagaag cagtaaaa                1188

<210>   1444
<211>   396
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   S-adenosylmethionine synthetase (metK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902715 (0.E+01)

<400>   1444
Met Ser Glu Arg Lys Leu Phe Thr Ser Glu Ser Val Ser Glu Gly His 
1               5                   10                  15      

Pro Asp Lys Ile Ala Asp Gln Ile Ser Asp Ala Ile Leu Asp Ala Ile 
            20                  25                  30          

Leu Ala Lys Asp Pro Glu Ala His Val Ala Ala Glu Thr Ala Val Tyr 
        35                  40                  45              

Thr Gly Ser Val His Val Phe Gly Glu Ile Ser Thr Asn Ala Tyr Val 
    50                  55                  60                  

Asp Ile Asn Arg Val Val Arg Asp Thr Ile Ala Glu Ile Gly Tyr Thr 
65                  70                  75                  80  

Asn Thr Glu Tyr Gly Phe Ser Ala Glu Thr Val Gly Val His Pro Ser 
                85                  90                  95      

Leu Val Glu Gln Ser Pro Asp Ile Ala Gln Gly Val Asn Glu Ala Leu 
            100                 105                 110         

Glu Val Arg Gly Asn Ala Asp Gln Asp Pro Leu Asp Leu Ile Gly Ala 
        115                 120                 125             

Gly Asp Gln Gly Leu Met Phe Gly Phe Ala Val Asp Glu Thr Glu Glu 
    130                 135                 140                 

Leu Met Pro Leu Pro Ile Ala Leu Ser His Lys Leu Val Arg Arg Leu 
145                 150                 155                 160 

Ala Glu Leu Arg Lys Ser Gly Glu Ile Ser Tyr Leu Arg Pro Asp Ala 
                165                 170                 175     

Lys Ser Gln Val Thr Val Glu Tyr Asp Glu Asn Asp Arg Pro Val Arg 
            180                 185                 190         

Val Asp Thr Val Val Ile Ser Thr Gln His Asp Pro Glu Ala Thr Asn 
        195                 200                 205             

Glu Gln Ile His Gln Asp Val Ile Asp Lys Val Ile Lys Glu Val Ile 
    210                 215                 220                 

Pro Ser Ser Tyr Leu Asp Asp Lys Thr Lys Phe Phe Ile Asn Pro Thr 
225                 230                 235                 240 

Gly Arg Phe Val Ile Gly Gly Pro Gln Gly Asp Ser Gly Leu Thr Gly 
                245                 250                 255     

Arg Lys Ile Ile Val Asp Thr Tyr Gly Gly Tyr Ser Arg His Gly Gly 
            260                 265                 270         

Gly Ala Phe Ser Gly Lys Asp Ala Thr Lys Val Asp Arg Ser Ala Ser 
        275                 280                 285             

Tyr Ala Ala Arg Tyr Ile Ala Lys Asn Ile Val Ala Ala Asp Leu Ala 
    290                 295                 300                 

Lys Lys Ala Glu Val Gln Leu Ala Tyr Ala Ile Gly Val Ala Gln Pro 
305                 310                 315                 320 

Val Ser Val Arg Ile Asp Thr Phe Gly Thr Gly Thr Val Ala Glu Ser 
                325                 330                 335     

Gln Leu Glu Lys Ala Ala Arg Gln Ile Phe Asp Leu Arg Pro Ala Gly 
            340                 345                 350         

Ile Ile Gln Met Leu Asp Leu Lys Arg Pro Ile Tyr Arg Gln Thr Ser 
        355                 360                 365             

Ala Tyr Gly His Met Gly Arg Thr Asp Ile Asp Leu Pro Trp Glu Arg 
    370                 375                 380                 

Leu Asp Lys Val Asp Ala Leu Lys Glu Ala Val Lys 
385                 390                 395     

<210>   1445
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1445
ttgactattg caaggttttc tagagcaaca gagtcatgga atggactcat ggttgagatt   60
tctccttgtt gcttggactt cattcaaaag tctgttaccc aagccttgtt caaacttcta   120
atacac                                                              126

<210>   1446
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1446
Met Thr Ile Ala Arg Phe Ser Arg Ala Thr Glu Ser Trp Asn Gly Leu 
1               5                   10                  15      

Met Val Glu Ile Ser Pro Cys Cys Leu Asp Phe Ile Gln Lys Ser Val 
            20                  25                  30          

Thr Gln Ala Leu Phe Lys Leu Leu Ile His 
        35                  40          

<210>   1447
<211>   933
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1447
atggtatcaa cgaaaacaca aattgctggt tttgagtttg acaattgctt gatgaatgca   60
gcaggtgtgg cttgtatgac gatagaggag ttagaagagg tcaaaaactc agcggcagga   120
acctttgtta ctaagacagc gaccttggac ttccgtcagg ggaatcctga gccacgctac   180
caagatgttc cacttggttc catcaactct atgggcttgc caaataatgg cttagactat   240
tatttggatt atcttttaga tttgcaggaa aaagagtcga accgaacttt cttcttatct   300
ctggtcggca tgtctccaga ggaaacccat actattttga aaaaagtcca agagagtgat   360
tttcgtggtc tgactgagct aaatctttcc tgtccaaatg ttccaggtaa acctcagatt   420
gcctatgatt ttgagacaac agaccggatt ttggcagaag tgtttgctta cttcaccaaa   480
cctcttggaa ttaaattgcc accttatttt gatattgttc actttgacca agcggcagct   540
attttcaaca aatatccgct caagtttgtc aactgcgtta actctatcgg aaacggcctc   600
tatatagaag acgaatctgt cgttattcgg cctaagaatg gttttggtgg aattggtgga   660
gaatacatca aaccgactgc tttagccaat gttcacgcct tttatcaacg tttaaatcct   720
caaatccaaa ttatcggaac aggtggcgtt ctgactggtc gagatgcctt tgaacacatc   780
ctctgtggag caagtatggt gcaggtggga acgacccttc acaaagaagg cgtcagtgct   840
tttgaccgca ttaccaatga actgaaagca atcatggtgg aaaaaggcta cgagagctta   900
gaagatttcc gtgggaaatt gcgctatatt gac                                933

<210>   1448
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydroorotate dehydrogenase A (pyrDa)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902716 (0.E+01)

<400>   1448
Met Val Ser Thr Lys Thr Gln Ile Ala Gly Phe Glu Phe Asp Asn Cys 
1               5                   10                  15      

Leu Met Asn Ala Ala Gly Val Ala Cys Met Thr Ile Glu Glu Leu Glu 
            20                  25                  30          

Glu Val Lys Asn Ser Ala Ala Gly Thr Phe Val Thr Lys Thr Ala Thr 
        35                  40                  45              

Leu Asp Phe Arg Gln Gly Asn Pro Glu Pro Arg Tyr Gln Asp Val Pro 
    50                  55                  60                  

Leu Gly Ser Ile Asn Ser Met Gly Leu Pro Asn Asn Gly Leu Asp Tyr 
65                  70                  75                  80  

Tyr Leu Asp Tyr Leu Leu Asp Leu Gln Glu Lys Glu Ser Asn Arg Thr 
                85                  90                  95      

Phe Phe Leu Ser Leu Val Gly Met Ser Pro Glu Glu Thr His Thr Ile 
            100                 105                 110         

Leu Lys Lys Val Gln Glu Ser Asp Phe Arg Gly Leu Thr Glu Leu Asn 
        115                 120                 125             

Leu Ser Cys Pro Asn Val Pro Gly Lys Pro Gln Ile Ala Tyr Asp Phe 
    130                 135                 140                 

Glu Thr Thr Asp Arg Ile Leu Ala Glu Val Phe Ala Tyr Phe Thr Lys 
145                 150                 155                 160 

Pro Leu Gly Ile Lys Leu Pro Pro Tyr Phe Asp Ile Val His Phe Asp 
                165                 170                 175     

Gln Ala Ala Ala Ile Phe Asn Lys Tyr Pro Leu Lys Phe Val Asn Cys 
            180                 185                 190         

Val Asn Ser Ile Gly Asn Gly Leu Tyr Ile Glu Asp Glu Ser Val Val 
        195                 200                 205             

Ile Arg Pro Lys Asn Gly Phe Gly Gly Ile Gly Gly Glu Tyr Ile Lys 
    210                 215                 220                 

Pro Thr Ala Leu Ala Asn Val His Ala Phe Tyr Gln Arg Leu Asn Pro 
225                 230                 235                 240 

Gln Ile Gln Ile Ile Gly Thr Gly Gly Val Leu Thr Gly Arg Asp Ala 
                245                 250                 255     

Phe Glu His Ile Leu Cys Gly Ala Ser Met Val Gln Val Gly Thr Thr 
            260                 265                 270         

Leu His Lys Glu Gly Val Ser Ala Phe Asp Arg Ile Thr Asn Glu Leu 
        275                 280                 285             

Lys Ala Ile Met Val Glu Lys Gly Tyr Glu Ser Leu Glu Asp Phe Arg 
    290                 295                 300                 

Gly Lys Leu Arg Tyr Ile Asp 
305                 310     

<210>   1449
<211>   1035
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1449
atgctagcca ttgaagaaag tcagaagttg actttatcaa atttaccgag cctgagccta   60
tttacaggga cagatcaggg tcagtttgaa gtgatgaaga gtcaaatgtt gaaacagatt   120
gggtatgatt ctgctgacct caactttgcc tactttgata tgaaagaagt agtttacaag   180
gatgtggaac tggagttggt cagccttcct ttctttgcgg atgagaaaat cgtgatatta   240
gattatttta tggatatcac gactgctaag aaacgctttt tgacagatga tgagcttaag   300
tcatttgagg aataccttga caatccttct ccaacaacca agttgataat ctttgcagaa   360
ggaaagctgg atagcaaaag acggttagtc aaattactta agcgtgatgc caaggccttc   420
gatgcagtag aagtaaaaga acaagaattg cgccagtact tccaaaagtg gagtcagaaa   480
caaggtctgc agtttaccaa tcattctttt gaaaatctcc tcatcaagtc ggggtttcaa   540
tttagcgaaa tccagaaaaa tcttctcttt ttacagtcct ataaggcgaa ttctgttatt   600
gaggaagagg atattgttaa cgcaattccc aagaccttgc aggacaatat ttttgattta   660
actcagttta ttctgactaa aaagatggat caggcgcgcg atttggtgag agacttgacc   720
ttgcaagggg aagatgaaat caaactgatt gcagtcatgc tgggacaatt tcggactttt   780
actcaggtga agattttggc ggagtctggc caaacagaat cgcagattgc aagtagttta   840
ggtagttatc tgggacgtaa cccaaatcct tatcaaatca agtttgcatt aagagattcg   900
agaggacttt ctttgagctt tttgaagcaa gctatttcct atttgattga gacagactat   960
cagattaaga caggtcttta tgaaaaaggt ttcctttttg aaaaggcact cttacagatt   1020
gctagtcagg tcaat                                                    1035

<210>   1450
<211>   345
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (DNA polymerase III, delta)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902717 (0.E+01)

<400>   1450
Met Leu Ala Ile Glu Glu Ser Gln Lys Leu Thr Leu Ser Asn Leu Pro 
1               5                   10                  15      

Ser Leu Ser Leu Phe Thr Gly Thr Asp Gln Gly Gln Phe Glu Val Met 
            20                  25                  30          

Lys Ser Gln Met Leu Lys Gln Ile Gly Tyr Asp Ser Ala Asp Leu Asn 
        35                  40                  45              

Phe Ala Tyr Phe Asp Met Lys Glu Val Val Tyr Lys Asp Val Glu Leu 
    50                  55                  60                  

Glu Leu Val Ser Leu Pro Phe Phe Ala Asp Glu Lys Ile Val Ile Leu 
65                  70                  75                  80  

Asp Tyr Phe Met Asp Ile Thr Thr Ala Lys Lys Arg Phe Leu Thr Asp 
                85                  90                  95      

Asp Glu Leu Lys Ser Phe Glu Glu Tyr Leu Asp Asn Pro Ser Pro Thr 
            100                 105                 110         

Thr Lys Leu Ile Ile Phe Ala Glu Gly Lys Leu Asp Ser Lys Arg Arg 
        115                 120                 125             

Leu Val Lys Leu Leu Lys Arg Asp Ala Lys Ala Phe Asp Ala Val Glu 
    130                 135                 140                 

Val Lys Glu Gln Glu Leu Arg Gln Tyr Phe Gln Lys Trp Ser Gln Lys 
145                 150                 155                 160 

Gln Gly Leu Gln Phe Thr Asn His Ser Phe Glu Asn Leu Leu Ile Lys 
                165                 170                 175     

Ser Gly Phe Gln Phe Ser Glu Ile Gln Lys Asn Leu Leu Phe Leu Gln 
            180                 185                 190         

Ser Tyr Lys Ala Asn Ser Val Ile Glu Glu Glu Asp Ile Val Asn Ala 
        195                 200                 205             

Ile Pro Lys Thr Leu Gln Asp Asn Ile Phe Asp Leu Thr Gln Phe Ile 
    210                 215                 220                 

Leu Thr Lys Lys Met Asp Gln Ala Arg Asp Leu Val Arg Asp Leu Thr 
225                 230                 235                 240 

Leu Gln Gly Glu Asp Glu Ile Lys Leu Ile Ala Val Met Leu Gly Gln 
                245                 250                 255     

Phe Arg Thr Phe Thr Gln Val Lys Ile Leu Ala Glu Ser Gly Gln Thr 
            260                 265                 270         

Glu Ser Gln Ile Ala Ser Ser Leu Gly Ser Tyr Leu Gly Arg Asn Pro 
        275                 280                 285             

Asn Pro Tyr Gln Ile Lys Phe Ala Leu Arg Asp Ser Arg Gly Leu Ser 
    290                 295                 300                 

Leu Ser Phe Leu Lys Gln Ala Ile Ser Tyr Leu Ile Glu Thr Asp Tyr 
305                 310                 315                 320 

Gln Ile Lys Thr Gly Leu Tyr Glu Lys Gly Phe Leu Phe Glu Lys Ala 
                325                 330                 335     

Leu Leu Gln Ile Ala Ser Gln Val Asn 
            340                 345 

<210>   1451
<211>   603
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1451
atggctatta tcttaccaga acttccatat gcatacgacg ctttggaacc atacatcgat   60
gcggaaacaa tgcatttgca ccatgacaaa caccatcaaa cttatgtcaa caatgccaat   120
gcagctttag aaaaacaccc tgaaatcggt gaagaccttg aagccttgct tgctgatgta   180
gaatctatcc cagctgatat ccgtcaagca cttatcaaca atggtggcgg acacttgaac   240
cacgctcttt tctgggaatt gatgactccc gagaaaacag ctccttcagc agaactggca   300
gcagcaatcg atgcaacatt tggttcattt gaagaattcc aagcagcctt cactgcagca   360
gcaacaactc gttttggttc aggttgggca tggttggttg tcaacaaaga agggaaactt   420
gaagtgactt caacagcaaa ccaagacaca ccaatctcag aaggtaaaaa accaatcttg   480
ggcttggacg tttgggaaca tgcttactac gtgaaatacc gcaacgtgcg tcctgactac   540
atcaaagctt tcttttcagt aatcaactgg aataaagtag atgaattgta cgcagctgct   600
aaa                                                                 603

<210>   1452
<211>   201
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   superoxide dismutase, manganese-dependent (sodA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902718 (e-117)

<400>   1452
Met Ala Ile Ile Leu Pro Glu Leu Pro Tyr Ala Tyr Asp Ala Leu Glu 
1               5                   10                  15      

Pro Tyr Ile Asp Ala Glu Thr Met His Leu His His Asp Lys His His 
            20                  25                  30          

Gln Thr Tyr Val Asn Asn Ala Asn Ala Ala Leu Glu Lys His Pro Glu 
        35                  40                  45              

Ile Gly Glu Asp Leu Glu Ala Leu Leu Ala Asp Val Glu Ser Ile Pro 
    50                  55                  60                  


Ala Asp Ile Arg Gln Ala Leu Ile Asn Asn Gly Gly Gly His Leu Asn 
65                  70                  75                  80  

His Ala Leu Phe Trp Glu Leu Met Thr Pro Glu Lys Thr Ala Pro Ser 
                85                  90                  95      

Ala Glu Leu Ala Ala Ala Ile Asp Ala Thr Phe Gly Ser Phe Glu Glu 
            100                 105                 110         

Phe Gln Ala Ala Phe Thr Ala Ala Ala Thr Thr Arg Phe Gly Ser Gly 
        115                 120                 125             

Trp Ala Trp Leu Val Val Asn Lys Glu Gly Lys Leu Glu Val Thr Ser 
    130                 135                 140                 

Thr Ala Asn Gln Asp Thr Pro Ile Ser Glu Gly Lys Lys Pro Ile Leu 
145                 150                 155                 160 

Gly Leu Asp Val Trp Glu His Ala Tyr Tyr Val Lys Tyr Arg Asn Val 
                165                 170                 175     

Arg Pro Asp Tyr Ile Lys Ala Phe Phe Ser Val Ile Asn Trp Asn Lys 
            180                 185                 190         

Val Asp Glu Leu Tyr Ala Ala Ala Lys 
        195                 200     

<210>   1453
<211>   510
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1453
atgcgaaaag aaattgcacc tgaattatac aactataaca agtttcctgg tccggagttc   60
catttacacg gggacaaggt cgaaacggaa gggatagctt tttccttggt tgaaaatatc   120
aaggatgcct ttgatgtgac gacttttaat cagcgttttt cagaagtatt aaccaagttt   180
gattatatcg tgggggactg gagcaacgaa cagcttcgcc tacgaggttt ttacaaggat   240
gaccgaacag aagaaaaact tgaaaaaatc agtcgtttac aagactacct tttagagtat   300
tgtagttatg gttgtgccta ttttgtctta gaaaatgaag cccctaagcg agcatcattt   360
gacaagaaaa tgcgtaagac ggaagaagaa acaccttcta gaaaaggaaa gaaaccgact   420
caaactaaac gaaagtcgaa tgcagataag aaaaatagac gtcgtcagaa agacgacaag   480
ggacaacgtc attttgtcat tcgtcagaag                                    510

<210>   1454
<211>   170
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902719 (7.E-96)

<400>   1454
Met Arg Lys Glu Ile Ala Pro Glu Leu Tyr Asn Tyr Asn Lys Phe Pro 
1               5                   10                  15      

Gly Pro Glu Phe His Leu His Gly Asp Lys Val Glu Thr Glu Gly Ile 
            20                  25                  30          

Ala Phe Ser Leu Val Glu Asn Ile Lys Asp Ala Phe Asp Val Thr Thr 
        35                  40                  45              

Phe Asn Gln Arg Phe Ser Glu Val Leu Thr Lys Phe Asp Tyr Ile Val 
    50                  55                  60                  

Gly Asp Trp Ser Asn Glu Gln Leu Arg Leu Arg Gly Phe Tyr Lys Asp 
65                  70                  75                  80  

Asp Arg Thr Glu Glu Lys Leu Glu Lys Ile Ser Arg Leu Gln Asp Tyr 
                85                  90                  95      

Leu Leu Glu Tyr Cys Ser Tyr Gly Cys Ala Tyr Phe Val Leu Glu Asn 
            100                 105                 110         

Glu Ala Pro Lys Arg Ala Ser Phe Asp Lys Lys Met Arg Lys Thr Glu 
        115                 120                 125             

Glu Glu Thr Pro Ser Arg Lys Gly Lys Lys Pro Thr Gln Thr Lys Arg 
    130                 135                 140                 

Lys Ser Asn Ala Asp Lys Lys Asn Arg Arg Arg Gln Lys Asp Asp Lys 
145                 150                 155                 160 

Gly Gln Arg His Phe Val Ile Arg Gln Lys 
                165                 170 

<210>   1455
<211>   1083
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1455
atgaaaccct caattcatag tttggtacat caaaccatgc aggaatgggt attggagcag   60
ggagaaaaga aattccgtgc agatcaaatc tgggaatggc tctaccgtaa acgtgtgcag   120
tcatttgaag aaatgaccaa cctttccaag gatttgattg ctaagctcaa tgaccagttt   180
gtggtcaatc ccttgaaaca acgtattgtg caagagtctg ctgatggtac agtcaaatat   240
ctctttgaat tgcccgacgg tatgttaatt gagactgtac tcatgcgtca acactatggt   300
ttatctgtct gtgtgaccac tcaggtcggc tgtaatatcg gttgtacctt ctgtgcctct   360
ggtttgatta agaagcaacg tgacctcaat aacggtgaaa tcgtagcgca aatcatgctg   420
gttcagaaat actttgatga gcgtggtcag gatgaacgca tcagccatat cgttgtcatg   480
ggaatcggtg agccctttga taattacaac aatgtcttga atttctttcg tactatcaat   540
gatgataaag gaatggctat cggtgctcgt cacatcacgg tttcaacctc aggtttggct   600
cataaaattc gtgactttgc tgatgaaggg gttcaggtca atcttgccgt gtctcttcac   660
gcacctaaca atgaacttcg ttcaagtatc atgaagatta accgtgcctt tccgattgaa   720
aaactctttg ctgctattga atactacatt gagacaacaa accgtcgtgt aacctttgaa   780
tatatcatgc ttaatgaagt caacgacggt gtagaacaag ccttggaatt gactgaattg   840
ctcaagaaca tcaagaaatt gtcttatgta aacttgattc cttataaccc agttagtgag   900
catgaccaat atagccgtag tcccaaagag tgcgtgttgg ctttctatga tacgcttaag   960
aaaaaagggg tcaactgtgt ggttcgtcaa gagcatggta cagatattga cgcagcttgt   1020
ggacaattgc gctctaacac aatgaaacgt gaccgccaga aggcagtcgc agcggtaaat   1080
cct                                                                 1083

<210>   1456
<211>   361
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902720 (0.E+01)

<400>   1456
Met Lys Pro Ser Ile His Ser Leu Val His Gln Thr Met Gln Glu Trp 
1               5                   10                  15      

Val Leu Glu Gln Gly Glu Lys Lys Phe Arg Ala Asp Gln Ile Trp Glu 
            20                  25                  30          

Trp Leu Tyr Arg Lys Arg Val Gln Ser Phe Glu Glu Met Thr Asn Leu 
        35                  40                  45              

Ser Lys Asp Leu Ile Ala Lys Leu Asn Asp Gln Phe Val Val Asn Pro 
    50                  55                  60                  

Leu Lys Gln Arg Ile Val Gln Glu Ser Ala Asp Gly Thr Val Lys Tyr 
65                  70                  75                  80  

Leu Phe Glu Leu Pro Asp Gly Met Leu Ile Glu Thr Val Leu Met Arg 
                85                  90                  95      


Gln His Tyr Gly Leu Ser Val Cys Val Thr Thr Gln Val Gly Cys Asn 
            100                 105                 110         

Ile Gly Cys Thr Phe Cys Ala Ser Gly Leu Ile Lys Lys Gln Arg Asp 
        115                 120                 125             

Leu Asn Asn Gly Glu Ile Val Ala Gln Ile Met Leu Val Gln Lys Tyr 
    130                 135                 140                 

Phe Asp Glu Arg Gly Gln Asp Glu Arg Ile Ser His Ile Val Val Met 
145                 150                 155                 160 

Gly Ile Gly Glu Pro Phe Asp Asn Tyr Asn Asn Val Leu Asn Phe Phe 
                165                 170                 175     

Arg Thr Ile Asn Asp Asp Lys Gly Met Ala Ile Gly Ala Arg His Ile 
            180                 185                 190         

Thr Val Ser Thr Ser Gly Leu Ala His Lys Ile Arg Asp Phe Ala Asp 
        195                 200                 205             

Glu Gly Val Gln Val Asn Leu Ala Val Ser Leu His Ala Pro Asn Asn 
    210                 215                 220                 

Glu Leu Arg Ser Ser Ile Met Lys Ile Asn Arg Ala Phe Pro Ile Glu 
225                 230                 235                 240 

Lys Leu Phe Ala Ala Ile Glu Tyr Tyr Ile Glu Thr Thr Asn Arg Arg 
                245                 250                 255     

Val Thr Phe Glu Tyr Ile Met Leu Asn Glu Val Asn Asp Gly Val Glu 
            260                 265                 270         

Gln Ala Leu Glu Leu Thr Glu Leu Leu Lys Asn Ile Lys Lys Leu Ser 
        275                 280                 285             

Tyr Val Asn Leu Ile Pro Tyr Asn Pro Val Ser Glu His Asp Gln Tyr 
    290                 295                 300                 

Ser Arg Ser Pro Lys Glu Cys Val Leu Ala Phe Tyr Asp Thr Leu Lys 
305                 310                 315                 320 

Lys Lys Gly Val Asn Cys Val Val Arg Gln Glu His Gly Thr Asp Ile 
                325                 330                 335     

Asp Ala Ala Cys Gly Gln Leu Arg Ser Asn Thr Met Lys Arg Asp Arg 
            340                 345                 350         

Gln Lys Ala Val Ala Ala Val Asn Pro 
        355                 360     

<210>   1457
<211>   477
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1457
atgaagaaga cttataatca tattttggtc tggggagtca ttttctatag catttgcatt   60
gtctgttttt gctttactcc tcaagaacaa tctaccgtgg gagtgggaac tccaggtatt   120
cagcatcttg gacgcctggt ttttcttttg actcctttca attctctctg gaaactgggc   180
gaagtgagtg acattggaca attatgttgg atttttttac aaaatatcct caatgtcttc   240
ttgttttttc ctctgatttt ccaactcctt tatctatttc caaatttgcg gaaaacaaaa   300
aaggtccttc tttttagttt tcttgtgagt cttggaatcg agtgtacgca attaatcttg   360
gactttttct ttgatttcaa tcgcgtcttt gagattgatg atttgtggac caacactttg   420
ggtggctatc tggcttggct cctttataaa cgattacata aaaacaaggt aaggaat      477

<210>   1458
<211>   159
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   VanZF-related protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902721 (4.E-80)

<400>   1458
Met Lys Lys Thr Tyr Asn His Ile Leu Val Trp Gly Val Ile Phe Tyr 
1               5                   10                  15      

Ser Ile Cys Ile Val Cys Phe Cys Phe Thr Pro Gln Glu Gln Ser Thr 
            20                  25                  30          

Val Gly Val Gly Thr Pro Gly Ile Gln His Leu Gly Arg Leu Val Phe 
        35                  40                  45              

Leu Leu Thr Pro Phe Asn Ser Leu Trp Lys Leu Gly Glu Val Ser Asp 
    50                  55                  60                  

Ile Gly Gln Leu Cys Trp Ile Phe Leu Gln Asn Ile Leu Asn Val Phe 
65                  70                  75                  80  

Leu Phe Phe Pro Leu Ile Phe Gln Leu Leu Tyr Leu Phe Pro Asn Leu 
                85                  90                  95      

Arg Lys Thr Lys Lys Val Leu Leu Phe Ser Phe Leu Val Ser Leu Gly 
            100                 105                 110         

Ile Glu Cys Thr Gln Leu Ile Leu Asp Phe Phe Phe Asp Phe Asn Arg 
        115                 120                 125             

Val Phe Glu Ile Asp Asp Leu Trp Thr Asn Thr Leu Gly Gly Tyr Leu 
    130                 135                 140                 

Ala Trp Leu Leu Tyr Lys Arg Leu His Lys Asn Lys Val Arg Asn 
145                 150                 155                 

<210>   1459
<211>   1539
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1459
atgagtattt tagaagttaa aaatctgagt cacggttttg gtgaccgtgc aatttttgaa   60
gatgtgtcct tccgtctcct caagggagaa catatcggcc tggtcggtgc caatggtgaa   120
ggaaaatcaa cctttatgag tatcgtgact ggtaaaatgc tgccagatga aggaaaggtt   180
gagtggtcca aatatgtgac ggctggttac ttggatcagc actctgtcct tgctgaaaga   240
cagtcggtgc gtgatgttct ccgtacggct tttgatgagc ttttcaaagc tgaagctcgt   300
atcaatgacc tctatatgaa aatggctgaa gacggcgcgg atgttgatgc tctcatggaa   360
gaagtaggag aacttcaaga ccgtctggag agtcgtgatt tctatacctt ggatgctaag   420
attgacgaag tagcgcgtgc tcttggtgtt atggactttg gcatggatac ggatgtaact   480
tctttgtcag gtgggcaaag aaccaaggtg cttttggcaa aacttctcct tgaaaagcct   540
gatatcttgc tgttggacga gccgaccaac tacttggatg ctgagcatat tgattggctc   600
aagcgctatc tccaaaacta tgagaatgcc tttgttctca tttcgcacga tattccattc   660
ctcaatgacg ttattaatat tgtctatcat gtggaaaatc aacagctgac gcgttactct   720
ggtgactact accagttcca agaagtttat gctatgaaga aatctcagct agaggcagcc   780
tacgaacgcc agcagaaaga gattgcagac ctcaaggact ttgtggctcg taataaagcc   840
cgtgttgcaa ctcgtaatat ggctatgtct cgtcaaaaga aattggataa gatggatatt   900
atcgaactcc aaagtgagaa accaaaacca tcctttgatt tcaaaccagc tcgtacacca   960
gggcgcttta tcttccaagc caagaacttg caaattggtt acgaccgtcc tcttactaag   1020
cctttaaatc ttaccttcga acgcaatcaa aaggttgcga ttattggtgc taatggtatt   1080
ggaaaaacaa ctctcttgaa gagtctcttg ggcattatct cgccaatcgc tggggaagtg   1140
gagcgtggag attatttaga acttggttat tttgagcagg aagtagaagg cggtaatcgc   1200
caaactcctc ttgaagctgt ctggaatgcc tttcctgccc ttaatcaagc agaagtccgt   1260
gcagcccttg cccgttgtgg tttgacaacc aaacatattg aaagccagat tcaagtatta   1320
tcagggggag agcaagccaa ggttcgtttc tgtctcttga tgaatcgtga aaacaacgtt   1380
ttagtgctgg acgagccgac caaccatttg gatgtggatg caaaggatga gctcaaacgc   1440
gctctcaaag aatatagggg atctatcctt atggtctgcc acgagccaga cttttatgaa   1500
ggctggatag accaaatatg ggattttaat aatttaact                          1539

<210>   1460
<211>   513
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902722 (0.E+01)

<400>   1460
Met Ser Ile Leu Glu Val Lys Asn Leu Ser His Gly Phe Gly Asp Arg 
1               5                   10                  15      

Ala Ile Phe Glu Asp Val Ser Phe Arg Leu Leu Lys Gly Glu His Ile 
            20                  25                  30          

Gly Leu Val Gly Ala Asn Gly Glu Gly Lys Ser Thr Phe Met Ser Ile 
        35                  40                  45              

Val Thr Gly Lys Met Leu Pro Asp Glu Gly Lys Val Glu Trp Ser Lys 
    50                  55                  60                  

Tyr Val Thr Ala Gly Tyr Leu Asp Gln His Ser Val Leu Ala Glu Arg 
65                  70                  75                  80  

Gln Ser Val Arg Asp Val Leu Arg Thr Ala Phe Asp Glu Leu Phe Lys 
                85                  90                  95      

Ala Glu Ala Arg Ile Asn Asp Leu Tyr Met Lys Met Ala Glu Asp Gly 
            100                 105                 110         

Ala Asp Val Asp Ala Leu Met Glu Glu Val Gly Glu Leu Gln Asp Arg 
        115                 120                 125             

Leu Glu Ser Arg Asp Phe Tyr Thr Leu Asp Ala Lys Ile Asp Glu Val 
    130                 135                 140                 

Ala Arg Ala Leu Gly Val Met Asp Phe Gly Met Asp Thr Asp Val Thr 
145                 150                 155                 160 

Ser Leu Ser Gly Gly Gln Arg Thr Lys Val Leu Leu Ala Lys Leu Leu 
                165                 170                 175     

Leu Glu Lys Pro Asp Ile Leu Leu Leu Asp Glu Pro Thr Asn Tyr Leu 
            180                 185                 190         

Asp Ala Glu His Ile Asp Trp Leu Lys Arg Tyr Leu Gln Asn Tyr Glu 
        195                 200                 205             

Asn Ala Phe Val Leu Ile Ser His Asp Ile Pro Phe Leu Asn Asp Val 
    210                 215                 220                 

Ile Asn Ile Val Tyr His Val Glu Asn Gln Gln Leu Thr Arg Tyr Ser 

225                 230                 235                 240 

Gly Asp Tyr Tyr Gln Phe Gln Glu Val Tyr Ala Met Lys Lys Ser Gln 
                245                 250                 255     

Leu Glu Ala Ala Tyr Glu Arg Gln Gln Lys Glu Ile Ala Asp Leu Lys 
            260                 265                 270         

Asp Phe Val Ala Arg Asn Lys Ala Arg Val Ala Thr Arg Asn Met Ala 
        275                 280                 285             

Met Ser Arg Gln Lys Lys Leu Asp Lys Met Asp Ile Ile Glu Leu Gln 
    290                 295                 300                 

Ser Glu Lys Pro Lys Pro Ser Phe Asp Phe Lys Pro Ala Arg Thr Pro 
305                 310                 315                 320 

Gly Arg Phe Ile Phe Gln Ala Lys Asn Leu Gln Ile Gly Tyr Asp Arg 
                325                 330                 335     

Pro Leu Thr Lys Pro Leu Asn Leu Thr Phe Glu Arg Asn Gln Lys Val 
            340                 345                 350         

Ala Ile Ile Gly Ala Asn Gly Ile Gly Lys Thr Thr Leu Leu Lys Ser 
        355                 360                 365             

Leu Leu Gly Ile Ile Ser Pro Ile Ala Gly Glu Val Glu Arg Gly Asp 
    370                 375                 380                 

Tyr Leu Glu Leu Gly Tyr Phe Glu Gln Glu Val Glu Gly Gly Asn Arg 
385                 390                 395                 400 

Gln Thr Pro Leu Glu Ala Val Trp Asn Ala Phe Pro Ala Leu Asn Gln 
                405                 410                 415     

Ala Glu Val Arg Ala Ala Leu Ala Arg Cys Gly Leu Thr Thr Lys His 
            420                 425                 430         

Ile Glu Ser Gln Ile Gln Val Leu Ser Gly Gly Glu Gln Ala Lys Val 
        435                 440                 445             

Arg Phe Cys Leu Leu Met Asn Arg Glu Asn Asn Val Leu Val Leu Asp 
    450                 455                 460                 

Glu Pro Thr Asn His Leu Asp Val Asp Ala Lys Asp Glu Leu Lys Arg 
465                 470                 475                 480 

Ala Leu Lys Glu Tyr Arg Gly Ser Ile Leu Met Val Cys His Glu Pro 
                485                 490                 495     

Asp Phe Tyr Glu Gly Trp Ile Asp Gln Ile Trp Asp Phe Asn Asn Leu 
            500                 505                 510         

Thr 
    

<210>   1461
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1461
atgaaaaaac tagcaaccct tcttttactg tctactgtag ccctagctgg gtgtagcagc   60
gtccaacgca gtctgcgtgg tgatgattat gttgattcca gtcttgctgc tgaagaaagt   120
tccaaagtag ctgcccaatc tgccaaggag ttaaacgatg ctttaacaaa cgaaaacgcc   180
aatttcccac aactatctaa ggaagttgct gaagatgaag ccgaagtgat tttccacaca   240
agccaaggtg atattcgcat taaactcttc cctaaactcg ctcctctagc ggttgaaaat   300
ttcctcactc acgccaaaga aggctactat aacggtatta ccttccaccg tgtcatcgat   360
ggctttatgg tccaaactgg agatccaaaa ggggacggta caggtggtca gtccatctgg   420
catgacaagg ataagactaa agacaaagga actggtttca agaacgagat tactccttat   480
ttgtataaca tccgtggtgc tcttgctatg gctaatactg gtcaaccaaa caccaatggc   540
agccagttct tcatcaacca aaactctaca gatacctctt ctaaactccc tacaagcaag   600
tatccacaga aaattattga agcctacaaa gaaggtggaa accctagtct agatggcaaa   660
cacccagtct ttggtcaagt gattgacggt atggatgttg tggataagat tgctaaggcc   720
gaaaaagatg aaaaagacaa gccaactact gctatcacaa tcgacagcat cgaagtggtg   780
aaagactacg attttaaatc t                                             801

<210>   1462
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidyl-prolyl cis-trans isomerase, cyclophilin-type
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902723 (e-152)

<400>   1462
Met Lys Lys Leu Ala Thr Leu Leu Leu Leu Ser Thr Val Ala Leu Ala 
1               5                   10                  15      

Gly Cys Ser Ser Val Gln Arg Ser Leu Arg Gly Asp Asp Tyr Val Asp 
            20                  25                  30          

Ser Ser Leu Ala Ala Glu Glu Ser Ser Lys Val Ala Ala Gln Ser Ala 
        35                  40                  45              

Lys Glu Leu Asn Asp Ala Leu Thr Asn Glu Asn Ala Asn Phe Pro Gln 
    50                  55                  60                  

Leu Ser Lys Glu Val Ala Glu Asp Glu Ala Glu Val Ile Phe His Thr 
65                  70                  75                  80  

Ser Gln Gly Asp Ile Arg Ile Lys Leu Phe Pro Lys Leu Ala Pro Leu 
                85                  90                  95      

Ala Val Glu Asn Phe Leu Thr His Ala Lys Glu Gly Tyr Tyr Asn Gly 
            100                 105                 110         

Ile Thr Phe His Arg Val Ile Asp Gly Phe Met Val Gln Thr Gly Asp 
        115                 120                 125             

Pro Lys Gly Asp Gly Thr Gly Gly Gln Ser Ile Trp His Asp Lys Asp 
    130                 135                 140                 

Lys Thr Lys Asp Lys Gly Thr Gly Phe Lys Asn Glu Ile Thr Pro Tyr 
145                 150                 155                 160 

Leu Tyr Asn Ile Arg Gly Ala Leu Ala Met Ala Asn Thr Gly Gln Pro 
                165                 170                 175     

Asn Thr Asn Gly Ser Gln Phe Phe Ile Asn Gln Asn Ser Thr Asp Thr 
            180                 185                 190         

Ser Ser Lys Leu Pro Thr Ser Lys Tyr Pro Gln Lys Ile Ile Glu Ala 
        195                 200                 205             

Tyr Lys Glu Gly Gly Asn Pro Ser Leu Asp Gly Lys His Pro Val Phe 
    210                 215                 220                 

Gly Gln Val Ile Asp Gly Met Asp Val Val Asp Lys Ile Ala Lys Ala 
225                 230                 235                 240 

Glu Lys Asp Glu Lys Asp Lys Pro Thr Thr Ala Ile Thr Ile Asp Ser 
                245                 250                 255     

Ile Glu Val Val Lys Asp Tyr Asp Phe Lys Ser 
            260                 265         

<210>   1463
<211>   201
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1463
atggactttt tttacaatgg cattgctatc acacccaata cctatctaag cgcctggttc   60
gtaaacttta ttgcagctct tcctctaaat ttcctaattg ttgaaccaat tgcccgtttt   120
atactaagtt cttttcagaa accatttact ggggaagaag ttgaagattt tcaagatgat   180
gatgaaatcc caactattat c                                             201

<210>   1464
<211>   67
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902724 (8.E-32)

<400>   1464
Met Asp Phe Phe Tyr Asn Gly Ile Ala Ile Thr Pro Asn Thr Tyr Leu 
1               5                   10                  15      

Ser Ala Trp Phe Val Asn Phe Ile Ala Ala Leu Pro Leu Asn Phe Leu 
            20                  25                  30          

Ile Val Glu Pro Ile Ala Arg Phe Ile Leu Ser Ser Phe Gln Lys Pro 
        35                  40                  45              

Phe Thr Gly Glu Glu Val Glu Asp Phe Gln Asp Asp Asp Glu Ile Pro 
    50                  55                  60                  

Thr Ile Ile 
65          

<210>   1465
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1465
atgaaaattt attttttgaa aaagtgggaa aacattgatt ctaagcgaat tttgaatcat   60
attcgaatgg gagtttttaa aatcatgttt cagtgg                             96

<210>   1466
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1466
Met Lys Ile Tyr Phe Leu Lys Lys Trp Glu Asn Ile Asp Ser Lys Arg 
1               5                   10                  15      

Ile Leu Asn His Ile Arg Met Gly Val Phe Lys Ile Met Phe Gln Trp 
            20                  25                  30          


<210>   1467
<211>   207
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1467
atgctatccg tgaatactat tttagaaaaa ttttataaag aacaccaagt caaacccttc   60
atatcgcctg aacgagagtt ggatacttgg cttctaagtc ccaagcccgt tcccaagcga   120
aatatggact tattagtaga tgattcacta gcaggagata tcattttact atggagaatc   180
cagtttggta cttttaccac tgaaaca                                       207

<210>   1468
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1468
Met Leu Ser Val Asn Thr Ile Leu Glu Lys Phe Tyr Lys Glu His Gln 
1               5                   10                  15      

Val Lys Pro Phe Ile Ser Pro Glu Arg Glu Leu Asp Thr Trp Leu Leu 
            20                  25                  30          

Ser Pro Lys Pro Val Pro Lys Arg Asn Met Asp Leu Leu Val Asp Asp 
        35                  40                  45              

Ser Leu Ala Gly Asp Ile Ile Leu Leu Trp Arg Ile Gln Phe Gly Thr 
    50                  55                  60                  

Phe Thr Thr Glu Thr 
65                  

<210>   1469
<211>   270
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1469
atggcagtta aaatccgttt gactcgtatg ggttctaaga aaaaaccttt ctaccgtatc   60
aacgtagcag attcacgttc accacgtgac ggacgtttca tcgaaacagt tggaacttac   120
aacccacttg ttgctgaaaa ccaagtaact ttgaaagaag accgcgttct tgcatggttg   180
gctaatggag ctcaaccttc agacacagta cgtaacatcc tttcaaaaga aggcgtattg   240
aaaaaattcc acgattctaa attttcaaaa                                    270

<210>   1470
<211>   90
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S16 (rpsP)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902726 (8.E-48)

<400>   1470
Met Ala Val Lys Ile Arg Leu Thr Arg Met Gly Ser Lys Lys Lys Pro 
1               5                   10                  15      

Phe Tyr Arg Ile Asn Val Ala Asp Ser Arg Ser Pro Arg Asp Gly Arg 
            20                  25                  30          

Phe Ile Glu Thr Val Gly Thr Tyr Asn Pro Leu Val Ala Glu Asn Gln 
        35                  40                  45              

Val Thr Leu Lys Glu Asp Arg Val Leu Ala Trp Leu Ala Asn Gly Ala 
    50                  55                  60                  

Gln Pro Ser Asp Thr Val Arg Asn Ile Leu Ser Lys Glu Gly Val Leu 
65                  70                  75                  80  

Lys Lys Phe His Asp Ser Lys Phe Ser Lys 
                85                  90  

<210>   1471
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1471
atggatacga ttgaaaatct cattattgcg attgtgaaac ccttaatttc acaaccagat   60
gccttaacta tcaagattga ggatacacca gaatttttgg aatatcattt gaatcttgat   120
caaagcgatg tgggtcgtgt aatcggtcgt aagggtcgca ctatttctgc gataagaacg   180
attgtctact ctgtcccaac tgaatacaaa aaagtaagaa tcgttattga cgaaaaa      237

<210>   1472
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   KH domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902727 (4.E-40)

<400>   1472
Met Asp Thr Ile Glu Asn Leu Ile Ile Ala Ile Val Lys Pro Leu Ile 
1               5                   10                  15      

Ser Gln Pro Asp Ala Leu Thr Ile Lys Ile Glu Asp Thr Pro Glu Phe 
            20                  25                  30          

Leu Glu Tyr His Leu Asn Leu Asp Gln Ser Asp Val Gly Arg Val Ile 
        35                  40                  45              

Gly Arg Lys Gly Arg Thr Ile Ser Ala Ile Arg Thr Ile Val Tyr Ser 
    50                  55                  60                  

Val Pro Thr Glu Tyr Lys Lys Val Arg Ile Val Ile Asp Glu Lys 
65                  70                  75                  

<210>   1473
<211>   798
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1473
gtggatttct ttatgaagag gtttgaagta tctacagaaa ttggtagcct ctctgttact   60
tatcaaaagc aaaagaaagt gctagtttgt ttaaacggag caggtttgct accaagttat   120
gaaaattttt cacttatact tgaaaaacct cctcctacaa ttggttattt gacaattgat   180
tttccgaaca caggtaggag tccgattcat gaccaagctg gaaaaaatct agataatctt   240
gcagatgcgg tttatgaagt acttgaagaa ttaggaattt ctgaatatat actttgtgca   300
catagttgga gtggaatttt agcttgcaaa ttactcgaga aaccaattaa gcgtcagact   360
ttagtagcaa ttgaaccgac aactaaaaaa gtcatgtttg ctgatttttc agaaaatcct   420
tatccagaaa tggaagagca gatgaggctg attgacgagt gtggtcctga actttatttt   480
aagaacttaa ctcaagcaac atttagtcct gaaacgaata aaaaaatctg ggaattaatg   540
caagaaaaag gcttagagtt ggaaaatcaa gatccagaat ttcagatatc tggagagatt   600
actgaggaag attttgagga tgtatctata gaagctcata ttcctgtatt tgttttttgt   660
cagccttata gagaaaaaga gtacagagaa tcagaatatt ggacttccaa tactaaactc   720
attttaggag ggaatcacca ttatttacaa tggtcagaat cggaaaaaat tgcggctatt   780
attcgagaat tgttagaa                                                 798

<210>   1474
<211>   266
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902728 (2.E-81)

<400>   1474
Met Asp Phe Phe Met Lys Arg Phe Glu Val Ser Thr Glu Ile Gly Ser 
1               5                   10                  15      

Leu Ser Val Thr Tyr Gln Lys Gln Lys Lys Val Leu Val Cys Leu Asn 
            20                  25                  30          

Gly Ala Gly Leu Leu Pro Ser Tyr Glu Asn Phe Ser Leu Ile Leu Glu 
        35                  40                  45              

Lys Pro Pro Pro Thr Ile Gly Tyr Leu Thr Ile Asp Phe Pro Asn Thr 
    50                  55                  60                  

Gly Arg Ser Pro Ile His Asp Gln Ala Gly Lys Asn Leu Asp Asn Leu 
65                  70                  75                  80  

Ala Asp Ala Val Tyr Glu Val Leu Glu Glu Leu Gly Ile Ser Glu Tyr 
                85                  90                  95      

Ile Leu Cys Ala His Ser Trp Ser Gly Ile Leu Ala Cys Lys Leu Leu 
            100                 105                 110         

Glu Lys Pro Ile Lys Arg Gln Thr Leu Val Ala Ile Glu Pro Thr Thr 
        115                 120                 125             

Lys Lys Val Met Phe Ala Asp Phe Ser Glu Asn Pro Tyr Pro Glu Met 
    130                 135                 140                 

Glu Glu Gln Met Arg Leu Ile Asp Glu Cys Gly Pro Glu Leu Tyr Phe 
145                 150                 155                 160 

Lys Asn Leu Thr Gln Ala Thr Phe Ser Pro Glu Thr Asn Lys Lys Ile 
                165                 170                 175     

Trp Glu Leu Met Gln Glu Lys Gly Leu Glu Leu Glu Asn Gln Asp Pro 
            180                 185                 190         

Glu Phe Gln Ile Ser Gly Glu Ile Thr Glu Glu Asp Phe Glu Asp Val 
        195                 200                 205             

Ser Ile Glu Ala His Ile Pro Val Phe Val Phe Cys Gln Pro Tyr Arg 
    210                 215                 220                 

Glu Lys Glu Tyr Arg Glu Ser Glu Tyr Trp Thr Ser Asn Thr Lys Leu 
225                 230                 235                 240 

Ile Leu Gly Gly Asn His His Tyr Leu Gln Trp Ser Glu Ser Glu Lys 
                245                 250                 255     

Ile Ala Ala Ile Ile Arg Glu Leu Leu Glu 
            260                 265     

<210>   1475
<211>   516
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1475
atgaactact ttaatgttgg gaaaatcgtt aatacgcagg gattacaggg ggagatgcga   60
gtcttgtctg tgacggattt tgcagaagaa cggtttaaaa aaggagctga gctggttttg   120
tttgatgaaa aagatcagtt tgtccaaaca gtgaccatcg ctagccaccg taaacagaag   180
aactttgaca ttattaaatt caaagatatg taccatatca atactatcga aaagtacaag   240
ggatacagtc tcaaggtcgc tgaggaagat ttgaatgacc tagacgatgg tgaattttac   300
tatcacgaga ttatcggttt ggaagtctat gagggtgata gcttggttgg aaccatcaag   360
gaaatcctgc aaccaggtgc taatgatgtc tgggtggtca aacgaaaagg caaacgtgat   420
ttgcttttac cttatatccc accagtggtt ctcaatgttg atattccaag taaacgggtc   480
gatgtggaaa tcttagaagg gttagacgat gaagat                             516

<210>   1476
<211>   172
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   16S rRNA processing protein RimM (rimM)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902730 (1.E-96)

<400>   1476
Met Asn Tyr Phe Asn Val Gly Lys Ile Val Asn Thr Gln Gly Leu Gln 
1               5                   10                  15      

Gly Glu Met Arg Val Leu Ser Val Thr Asp Phe Ala Glu Glu Arg Phe 
            20                  25                  30          

Lys Lys Gly Ala Glu Leu Val Leu Phe Asp Glu Lys Asp Gln Phe Val 
        35                  40                  45              

Gln Thr Val Thr Ile Ala Ser His Arg Lys Gln Lys Asn Phe Asp Ile 
    50                  55                  60                  

Ile Lys Phe Lys Asp Met Tyr His Ile Asn Thr Ile Glu Lys Tyr Lys 
65                  70                  75                  80  

Gly Tyr Ser Leu Lys Val Ala Glu Glu Asp Leu Asn Asp Leu Asp Asp 
                85                  90                  95      

Gly Glu Phe Tyr Tyr His Glu Ile Ile Gly Leu Glu Val Tyr Glu Gly 
            100                 105                 110         

Asp Ser Leu Val Gly Thr Ile Lys Glu Ile Leu Gln Pro Gly Ala Asn 
        115                 120                 125             

Asp Val Trp Val Val Lys Arg Lys Gly Lys Arg Asp Leu Leu Leu Pro 
    130                 135                 140                 

Tyr Ile Pro Pro Val Val Leu Asn Val Asp Ile Pro Ser Lys Arg Val 
145                 150                 155                 160 

Asp Val Glu Ile Leu Glu Gly Leu Asp Asp Glu Asp 
                165                 170         

<210>   1477
<211>   717
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1477
atgaagattg atattttaac cctctttcca gagatgtttt ctccactgga gcactcaatc   60
gttggaaagg ctcgagaaaa agggctcttg gatatccagt atcataattt tcgagaaaat   120
gctgaaaagg cccgtcatgt agatgatgag ccctacggag gcggtcaggg catgttgctc   180
agagcacaac ctattttcga ttcctttgat gctattgaaa agaaaaatcc gcgcgttatt   240
ctccttgatc ctgctggaaa gcagtttgat caggcttatg ctgaagattt ggctcaagag   300
gaagagctaa tctttatctg tgggcactat gagggttatg atgagcgcat taagaccttg   360
gtaacagatg agatttccct aggtgactat gtcctcactg gtggagaatt ggcagctatg   420
accatgattg atgctacagt tcgcctgatt ccagaagtga ttggcaagga gtctagccac   480
caagatgata gtttttcttc aggtctttta gaatatcctc agtacacacg tccctatgat   540
tatcgaggca tggtcgtgcc agatgtattg atgagtggcc accatgaaaa gattcgtcag   600
tggcgattgt acgagagttt aaagaaaacc tacgagcgca gaccggattt acttgaacat   660
tatcaactga cagtagaaga agaaaaaatg ctggcagaaa tcaaagaaaa caaagaa      717

<210>   1478
<211>   239
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tRNA (guanine-N1)-methyltransferase (trmD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902731 (e-138)

<400>   1478
Met Lys Ile Asp Ile Leu Thr Leu Phe Pro Glu Met Phe Ser Pro Leu 
1               5                   10                  15      

Glu His Ser Ile Val Gly Lys Ala Arg Glu Lys Gly Leu Leu Asp Ile 
            20                  25                  30          

Gln Tyr His Asn Phe Arg Glu Asn Ala Glu Lys Ala Arg His Val Asp 
        35                  40                  45              

Asp Glu Pro Tyr Gly Gly Gly Gln Gly Met Leu Leu Arg Ala Gln Pro 
    50                  55                  60                  

Ile Phe Asp Ser Phe Asp Ala Ile Glu Lys Lys Asn Pro Arg Val Ile 
65                  70                  75                  80  

Leu Leu Asp Pro Ala Gly Lys Gln Phe Asp Gln Ala Tyr Ala Glu Asp 
                85                  90                  95      

Leu Ala Gln Glu Glu Glu Leu Ile Phe Ile Cys Gly His Tyr Glu Gly 
            100                 105                 110         

Tyr Asp Glu Arg Ile Lys Thr Leu Val Thr Asp Glu Ile Ser Leu Gly 
        115                 120                 125             

Asp Tyr Val Leu Thr Gly Gly Glu Leu Ala Ala Met Thr Met Ile Asp 
    130                 135                 140                 

Ala Thr Val Arg Leu Ile Pro Glu Val Ile Gly Lys Glu Ser Ser His 
145                 150                 155                 160 

Gln Asp Asp Ser Phe Ser Ser Gly Leu Leu Glu Tyr Pro Gln Tyr Thr 
                165                 170                 175     

Arg Pro Tyr Asp Tyr Arg Gly Met Val Val Pro Asp Val Leu Met Ser 
            180                 185                 190         

Gly His His Glu Lys Ile Arg Gln Trp Arg Leu Tyr Glu Ser Leu Lys 
        195                 200                 205             

Lys Thr Tyr Glu Arg Arg Pro Asp Leu Leu Glu His Tyr Gln Leu Thr 
    210                 215                 220                 

Val Glu Glu Glu Lys Met Leu Ala Glu Ile Lys Glu Asn Lys Glu 
225                 230                 235                 

<210>   1479
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1479
atgcaagtaa tcaaacgtaa tggcgaaatt gctgaattta atccagataa gatttaccaa   60
gccatcttga aggcagccca aactgtttat gttttgacag atgatttgcg tcaaaatctt   120
gctcaagtca ctaagaaggt agttttggat ttacaagaag ccaaggtgga acgtgcgact   180
atcagtatga ttcaatctat ggttgaacat cgtttattgg gcgcaggtta cattaccatt   240
gcagaacact acatttccta tcgtttacaa cgtgacttgg aaagaagtgg ttatggagat   300
catatcgcag ttcatttaca ttttgaacaa attcgc                             336

<210>   1480
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   ribonucleoside-diphosphate reductase, alpha subunit, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902732 (2.E-59)

<400>   1480
Met Gln Val Ile Lys Arg Asn Gly Glu Ile Ala Glu Phe Asn Pro Asp 
1               5                   10                  15      

Lys Ile Tyr Gln Ala Ile Leu Lys Ala Ala Gln Thr Val Tyr Val Leu 
            20                  25                  30          

Thr Asp Asp Leu Arg Gln Asn Leu Ala Gln Val Thr Lys Lys Val Val 
        35                  40                  45              

Leu Asp Leu Gln Glu Ala Lys Val Glu Arg Ala Thr Ile Ser Met Ile 
    50                  55                  60                  

Gln Ser Met Val Glu His Arg Leu Leu Gly Ala Gly Tyr Ile Thr Ile 
65                  70                  75                  80  

Ala Glu His Tyr Ile Ser Tyr Arg Leu Gln Arg Asp Leu Glu Arg Ser 
                85                  90                  95      

Gly Tyr Gly Asp His Ile Ala Val His Leu His Phe Glu Gln Ile Arg 
            100                 105                 110         


<210>   1481
<211>   318
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1481
atgagacata aattccagca agttctaaat aaaatacatg attttttaaa tggatatgac   60
caacctgacc agactgaaac caactccctt acagccacta ttgaagaggc tatccagaaa   120
caaaccgctg ttcaccttat cttgtctgag acaagcttta caggtgacat catcaaatat   180
gatcagcaag gccagcaaat tatcgtgaaa aatttttcca aaaatgtgag ccggattatc   240
cgtataagcg atattcaacg cctgcgattt gtcccctcaa ctgtccaaac agcccaaaaa   300
aatagattta agaaagag                                                 318

<210>   1482
<211>   106
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902733 (7.E-55)

<400>   1482
Met Arg His Lys Phe Gln Gln Val Leu Asn Lys Ile His Asp Phe Leu 
1               5                   10                  15      

Asn Gly Tyr Asp Gln Pro Asp Gln Thr Glu Thr Asn Ser Leu Thr Ala 
            20                  25                  30          

Thr Ile Glu Glu Ala Ile Gln Lys Gln Thr Ala Val His Leu Ile Leu 
        35                  40                  45              

Ser Glu Thr Ser Phe Thr Gly Asp Ile Ile Lys Tyr Asp Gln Gln Gly 
    50                  55                  60                  

Gln Gln Ile Ile Val Lys Asn Phe Ser Lys Asn Val Ser Arg Ile Ile 
65                  70                  75                  80  

Arg Ile Ser Asp Ile Gln Arg Leu Arg Phe Val Pro Ser Thr Val Gln 
                85                  90                  95      

Thr Ala Gln Lys Asn Arg Phe Lys Lys Glu 
            100                 105     

<210>   1483
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1483
atgaaactaa aaaaggagaa gaaaatggca gaatttacat ttgaaatcga agagcacttg   60
ttgactcttt ctgaaaacga aaaaggttgg accaaggaaa ttaaccgtgt gagctttaat   120
ggtgcccctg caaagtttga tattcgtgct tggagtccag accatactaa aatgggcaaa   180
gggattactc tctcaaatga agaatttcaa acgatggtgg atgcctttaa aggcaac      237

<210>   1484
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902734 (5.E-43)

<400>   1484
Met Lys Leu Lys Lys Glu Lys Lys Met Ala Glu Phe Thr Phe Glu Ile 
1               5                   10                  15      

Glu Glu His Leu Leu Thr Leu Ser Glu Asn Glu Lys Gly Trp Thr Lys 
            20                  25                  30          

Glu Ile Asn Arg Val Ser Phe Asn Gly Ala Pro Ala Lys Phe Asp Ile 
        35                  40                  45              

Arg Ala Trp Ser Pro Asp His Thr Lys Met Gly Lys Gly Ile Thr Leu 
    50                  55                  60                  

Ser Asn Glu Glu Phe Gln Thr Met Val Asp Ala Phe Lys Gly Asn 
65                  70                  75                  

<210>   1485
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1485
atgaaaatca aagagcaaac taggaagcta gccgcaggct gctcaaaaca ctgttttgag   60
gttgtggatg aaactgacga agtcagtaac catacatacg gcaaggcaaa gctgacgcgg   120
tttgaagaga ttttcgaaga gtat                                          144

<210>   1486
<211>   48

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1486
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Asn His Thr 
            20                  25                  30          

Tyr Gly Lys Ala Lys Leu Thr Arg Phe Glu Glu Ile Phe Glu Glu Tyr 
        35                  40                  45              


<210>   1487
<211>   534
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1487
ttgaaaaaag ctcacgttta tgctatccct gctattgggg ctgctctcat tgctgctttg   60
gcacaaatca gtcttccaat tggacctgtt cccttcactc tgcaaaactt tgcaatcggc   120
ttgattgcta ctgtctttag accgagagag gctgtacttt ctgctggact ctatcttctt   180
ctaggtgcta tcggtcttcc tgtctttgca ggaggtggag ctggttttca ggctttagtt   240
ggccctactg caggctatct ttggttttat ctcgtttact ctggacttac ttcctctcta   300
accaacagca agagtggtgt tgttaagatt tttcttgcaa acctcttggg tgatgccctt   360

gtctttgtcg gcgggattct cagcttgcat ttcctagctg gaatggcatt tgaaaaagct   420
cttgctgtgg gggttcttcc ctttatcatt ccagaccttg gcaaacttct agctattagt   480
tttattagcc gtcccctact tcaacgcctt aaaaatcagg cttactttac taac         534

<210>   1488
<211>   178
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (Biotin synthase)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902735 (2.E-95)

<400>   1488
Met Lys Lys Ala His Val Tyr Ala Ile Pro Ala Ile Gly Ala Ala Leu 
1               5                   10                  15      

Ile Ala Ala Leu Ala Gln Ile Ser Leu Pro Ile Gly Pro Val Pro Phe 
            20                  25                  30          

Thr Leu Gln Asn Phe Ala Ile Gly Leu Ile Ala Thr Val Phe Arg Pro 
        35                  40                  45              

Arg Glu Ala Val Leu Ser Ala Gly Leu Tyr Leu Leu Leu Gly Ala Ile 
    50                  55                  60                  

Gly Leu Pro Val Phe Ala Gly Gly Gly Ala Gly Phe Gln Ala Leu Val 
65                  70                  75                  80  

Gly Pro Thr Ala Gly Tyr Leu Trp Phe Tyr Leu Val Tyr Ser Gly Leu 
                85                  90                  95      

Thr Ser Ser Leu Thr Asn Ser Lys Ser Gly Val Val Lys Ile Phe Leu 
            100                 105                 110         

Ala Asn Leu Leu Gly Asp Ala Leu Val Phe Val Gly Gly Ile Leu Ser 
        115                 120                 125             

Leu His Phe Leu Ala Gly Met Ala Phe Glu Lys Ala Leu Ala Val Gly 
    130                 135                 140                 

Val Leu Pro Phe Ile Ile Pro Asp Leu Gly Lys Leu Leu Ala Ile Ser 
145                 150                 155                 160 

Phe Ile Ser Arg Pro Leu Leu Gln Arg Leu Lys Asn Gln Ala Tyr Phe 
                165                 170                 175     

Thr Asn 
        

<210>   1489
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1489
atgagagaat atgatatcat tgctatcggt ggaggtagcg gaggaatcgc taccatgaac   60
cgtgctggtg aacatggagc caaagcagcc gttattgagg aaaagaaatt aggtggaacc   120
tgtgtcaacg tcggttgtgt tcctaaaaaa atcatgtggt acggggcgca aatcgctgag   180
actttccatc aatttggaga agactacggc tttaagacta ctgatcttaa ctttgacttt   240
gcaaccctac gtcgcaatcg tgaagcctac attgatcgcg ctcgttcttc ttatgatggt   300
agttttaaac gcaacggtgt agacttgatt gaaggtcatg ctgaatttgt agattctcat   360
actgtaagcg taaatggtga actgattcgt gctaaacata tcgtgattgc tacaggtgcc   420
catccaagta ttcctaatat tcctggtgct gagctaggtg gctcttctga tgatgtattt   480
gcctgggaag aacttccaga gtcaattgcc attctaggcg ctggttatat cgccgttgaa   540
ttagctggcg tactccacac ttttggtgtc aagacagatc tctttgttcg ccgcgatcgt   600
cctttacgtg gttttgattc ctacatcgtt gaaggtttgg tcaaggaaat ggaaagaaca   660
aacttaccac ttcacactca caaagtccct gtcaagttag aaaaaactac tgacggcatt   720
accattcatt tcgaagatgg tactagtcac acagctagcc aagttatctg ggctacaggt   780
cgccgtccaa acgttaaggg cttgcaactt gaaaaagctg gagtgactct gaacgaacgt   840
ggctttatcc aagtggatga ataccaaaat actgttgttg agggaatcta tgctctaggt   900
gatgtaacgg gcgagaaaga actgactcca gttgcaatca aggccggacg taccctatct   960
gaacgtctct ttaacggaaa aactactgca aaaatggatt actcaactat tccaactgtt   1020
gtcttttcac accctgctat cggaactgtt ggtttgacag aagagcaagc tattaaagaa   1080
tacggtcaag accaaatcaa ggtttataaa tcaagctttg catctatgta ctctgcttgc   1140
acttgcaacc gtcaagaatc ccgtttcaaa ctcataacag ctggttcaga agaaaaagtt   1200
gtcggacttc atggaattgg ctacggcgtt gatgaaatga ttcagggatt tgccgttgct   1260
atcaaaatgg gagcaaccaa ggctgacttt gatgcaactg tggcaattca cccaactgca   1320
tctgaagaat ttgtaaccat gcgt                                          1344

<210>   1490
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutathione reductase (gor)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902736 (0.E+01)

<400>   1490
Met Arg Glu Tyr Asp Ile Ile Ala Ile Gly Gly Gly Ser Gly Gly Ile 
1               5                   10                  15      

Ala Thr Met Asn Arg Ala Gly Glu His Gly Ala Lys Ala Ala Val Ile 
            20                  25                  30          

Glu Glu Lys Lys Leu Gly Gly Thr Cys Val Asn Val Gly Cys Val Pro 
        35                  40                  45              

Lys Lys Ile Met Trp Tyr Gly Ala Gln Ile Ala Glu Thr Phe His Gln 
    50                  55                  60                  

Phe Gly Glu Asp Tyr Gly Phe Lys Thr Thr Asp Leu Asn Phe Asp Phe 
65                  70                  75                  80  

Ala Thr Leu Arg Arg Asn Arg Glu Ala Tyr Ile Asp Arg Ala Arg Ser 
                85                  90                  95      

Ser Tyr Asp Gly Ser Phe Lys Arg Asn Gly Val Asp Leu Ile Glu Gly 
            100                 105                 110         

His Ala Glu Phe Val Asp Ser His Thr Val Ser Val Asn Gly Glu Leu 
        115                 120                 125             

Ile Arg Ala Lys His Ile Val Ile Ala Thr Gly Ala His Pro Ser Ile 
    130                 135                 140                 

Pro Asn Ile Pro Gly Ala Glu Leu Gly Gly Ser Ser Asp Asp Val Phe 
145                 150                 155                 160 

Ala Trp Glu Glu Leu Pro Glu Ser Ile Ala Ile Leu Gly Ala Gly Tyr 
                165                 170                 175     

Ile Ala Val Glu Leu Ala Gly Val Leu His Thr Phe Gly Val Lys Thr 
            180                 185                 190         


Asp Leu Phe Val Arg Arg Asp Arg Pro Leu Arg Gly Phe Asp Ser Tyr 
        195                 200                 205             

Ile Val Glu Gly Leu Val Lys Glu Met Glu Arg Thr Asn Leu Pro Leu 
    210                 215                 220                 

His Thr His Lys Val Pro Val Lys Leu Glu Lys Thr Thr Asp Gly Ile 
225                 230                 235                 240 

Thr Ile His Phe Glu Asp Gly Thr Ser His Thr Ala Ser Gln Val Ile 
                245                 250                 255     

Trp Ala Thr Gly Arg Arg Pro Asn Val Lys Gly Leu Gln Leu Glu Lys 
            260                 265                 270         

Ala Gly Val Thr Leu Asn Glu Arg Gly Phe Ile Gln Val Asp Glu Tyr 
        275                 280                 285             

Gln Asn Thr Val Val Glu Gly Ile Tyr Ala Leu Gly Asp Val Thr Gly 
    290                 295                 300                 

Glu Lys Glu Leu Thr Pro Val Ala Ile Lys Ala Gly Arg Thr Leu Ser 
305                 310                 315                 320 

Glu Arg Leu Phe Asn Gly Lys Thr Thr Ala Lys Met Asp Tyr Ser Thr 
                325                 330                 335     

Ile Pro Thr Val Val Phe Ser His Pro Ala Ile Gly Thr Val Gly Leu 
            340                 345                 350         

Thr Glu Glu Gln Ala Ile Lys Glu Tyr Gly Gln Asp Gln Ile Lys Val 
        355                 360                 365             

Tyr Lys Ser Ser Phe Ala Ser Met Tyr Ser Ala Cys Thr Cys Asn Arg 
    370                 375                 380                 

Gln Glu Ser Arg Phe Lys Leu Ile Thr Ala Gly Ser Glu Glu Lys Val 
385                 390                 395                 400 

Val Gly Leu His Gly Ile Gly Tyr Gly Val Asp Glu Met Ile Gln Gly 
                405                 410                 415     

Phe Ala Val Ala Ile Lys Met Gly Ala Thr Lys Ala Asp Phe Asp Ala 
            420                 425                 430         

Thr Val Ala Ile His Pro Thr Ala Ser Glu Glu Phe Val Thr Met Arg 
        435                 440                 445             


<210>   1491
<211>   1197
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1491
atgaagaaaa agaatggtaa agctaaaaag tggcaactgt atgcagcaat cggtgctgcg   60
agtgtagttg tattgggtgc tggggggatt ttactcttta gacaaccttc tcagactgct   120
ctaaaagatg agcctactca tcttgttgtt gccaaggaag gaagcgtggc ctcctctgtt   180
ttattgtcag ggacagtaac agcaaaaaat gaacaatatg tttattttga tgctagtaag   240
ggtgatttag atgaaatcct tgtttctgtg ggcgataagg tcagcgaagg gcaggcttta   300
gtcaagtaca gtagttcaga agcgcaggcg gcctatgatt cagctagtcg agcagtagct   360
agggcagatc gtcatatcaa tgaactcaat caagcacgaa atgaagccgc ttcagctccg   420
gctccacagt taccagcgcc agtaggagga gaagatgcaa cggtgcaaag cccaactcca   480
gtggctggaa attctgttgc ttctattgac gctcaattgg gtgatgcccg tgatgcgcgt   540
gcagatgctg cggcgcaatt aagcaaggct caaagtcaat tggatgcaac aactgttctc   600
agtaccctag agggaactgt ggtcgaagtc aatagcaatg tttctaaatc tccaacaggg   660
gcgagtcaag ttatggttca tattgtcagc aatgaaaatt tacaagtcaa gggagaattg   720
tctgagtaca atctagccaa cctttctgta ggtcaagaag taagctttac ttctaaagtg   780
tatcctgata aaaaatggac tgggaaatta agctatattt ctgactatcc taaaaacaat   840
ggtgaagcag ctagtccagc agccgggaat aatacaggtt ctaaataccc ttatactatt   900
gatgtgacag gcgaggttgg tgatttgaaa caaggttttt ctgtcaacat tgaggttaaa   960
agcaaaacta aggctattct tgttcctgtt agcagtctag taatggatga tagtaaaaat   1020
tatgtctgga ttgtggatga acaacaaaag gctaaaaaag ttgaggtttc attgggaaat   1080
gctgacgcag aaaatcaaga aatcacttct ggtttaacga acggtgctaa ggtcatcagt   1140
aatccaacat cttccttgga agaaggaaaa gaggtgaagg ctgatgaagc aactaat      1197

<210>   1492
<211>   399
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902737 (0.E+01)

<400>   1492
Met Lys Lys Lys Asn Gly Lys Ala Lys Lys Trp Gln Leu Tyr Ala Ala 
1               5                   10                  15      

Ile Gly Ala Ala Ser Val Val Val Leu Gly Ala Gly Gly Ile Leu Leu 
            20                  25                  30          

Phe Arg Gln Pro Ser Gln Thr Ala Leu Lys Asp Glu Pro Thr His Leu 
        35                  40                  45              

Val Val Ala Lys Glu Gly Ser Val Ala Ser Ser Val Leu Leu Ser Gly 
    50                  55                  60                  

Thr Val Thr Ala Lys Asn Glu Gln Tyr Val Tyr Phe Asp Ala Ser Lys 
65                  70                  75                  80  

Gly Asp Leu Asp Glu Ile Leu Val Ser Val Gly Asp Lys Val Ser Glu 
                85                  90                  95      

Gly Gln Ala Leu Val Lys Tyr Ser Ser Ser Glu Ala Gln Ala Ala Tyr 
            100                 105                 110         

Asp Ser Ala Ser Arg Ala Val Ala Arg Ala Asp Arg His Ile Asn Glu 
        115                 120                 125             

Leu Asn Gln Ala Arg Asn Glu Ala Ala Ser Ala Pro Ala Pro Gln Leu 
    130                 135                 140                 

Pro Ala Pro Val Gly Gly Glu Asp Ala Thr Val Gln Ser Pro Thr Pro 
145                 150                 155                 160 

Val Ala Gly Asn Ser Val Ala Ser Ile Asp Ala Gln Leu Gly Asp Ala 
                165                 170                 175     

Arg Asp Ala Arg Ala Asp Ala Ala Ala Gln Leu Ser Lys Ala Gln Ser 
            180                 185                 190         

Gln Leu Asp Ala Thr Thr Val Leu Ser Thr Leu Glu Gly Thr Val Val 
        195                 200                 205             

Glu Val Asn Ser Asn Val Ser Lys Ser Pro Thr Gly Ala Ser Gln Val 
    210                 215                 220                 

Met Val His Ile Val Ser Asn Glu Asn Leu Gln Val Lys Gly Glu Leu 
225                 230                 235                 240 

Ser Glu Tyr Asn Leu Ala Asn Leu Ser Val Gly Gln Glu Val Ser Phe 
                245                 250                 255     

Thr Ser Lys Val Tyr Pro Asp Lys Lys Trp Thr Gly Lys Leu Ser Tyr 
            260                 265                 270         

Ile Ser Asp Tyr Pro Lys Asn Asn Gly Glu Ala Ala Ser Pro Ala Ala 
        275                 280                 285             

Gly Asn Asn Thr Gly Ser Lys Tyr Pro Tyr Thr Ile Asp Val Thr Gly 
    290                 295                 300                 

Glu Val Gly Asp Leu Lys Gln Gly Phe Ser Val Asn Ile Glu Val Lys 
305                 310                 315                 320 

Ser Lys Thr Lys Ala Ile Leu Val Pro Val Ser Ser Leu Val Met Asp 
                325                 330                 335     

Asp Ser Lys Asn Tyr Val Trp Ile Val Asp Glu Gln Gln Lys Ala Lys 
            340                 345                 350         

Lys Val Glu Val Ser Leu Gly Asn Ala Asp Ala Glu Asn Gln Glu Ile 
        355                 360                 365             

Thr Ser Gly Leu Thr Asn Gly Ala Lys Val Ile Ser Asn Pro Thr Ser 
    370                 375                 380                 

Ser Leu Glu Glu Gly Lys Glu Val Lys Ala Asp Glu Ala Thr Asn 
385                 390                 395                 

<210>   1493
<211>   699
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1493
atgaagcaac taattagtct aaaaaatatc ttcagaagtt accgtaatgg tgaccaagaa   60
ctgcaggttc tcaaaaatat caatctagaa gtgaatgagg gtgaatttgt agccatcatg   120
ggaccatctg ggtctggtaa gtccactctg atgaatacga ttggcatgtt ggatacacca   180
accagtggag aatattatct tgaaggtcaa gaagtggctg ggcttggtga aaaacaacta   240
gctaaggtcc gtaaccaaca aatcggtttt gtctttcagc agttctttct tctatcgaag   300
ctcaatgctc tgcaaaatgt agaattgccc ttgatttacg caggagtttc gtcttcaaaa   360
cgtcgcaagt tggctgagga atatttagac aaggttgaat tgacagaacg tagtcaccat   420
ttaccttcag aattatctgg tggtcaaaag caacgtgtag ccattgcgcg tgccttggta   480
aacaatcctt ctattatcct agcggatgaa ccgacaggag ccttggatac caaaacaggt   540
aaccaaatta tgcaattatt ggttgatttg aataaagaag gaaaaaccat tatcatggta   600
acgcatgagc ctgagattgc tgcctatgcc aaacgtcaga ttgtcattcg ggatggggtc   660
atttcgtctg acagtgctca gttaggaaag gaggaaaac                          699

<210>   1494
<211>   233
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902738 (e-128)

<400>   1494
Met Lys Gln Leu Ile Ser Leu Lys Asn Ile Phe Arg Ser Tyr Arg Asn 
1               5                   10                  15      

Gly Asp Gln Glu Leu Gln Val Leu Lys Asn Ile Asn Leu Glu Val Asn 
            20                  25                  30          

Glu Gly Glu Phe Val Ala Ile Met Gly Pro Ser Gly Ser Gly Lys Ser 
        35                  40                  45              

Thr Leu Met Asn Thr Ile Gly Met Leu Asp Thr Pro Thr Ser Gly Glu 
    50                  55                  60                  

Tyr Tyr Leu Glu Gly Gln Glu Val Ala Gly Leu Gly Glu Lys Gln Leu 
65                  70                  75                  80  

Ala Lys Val Arg Asn Gln Gln Ile Gly Phe Val Phe Gln Gln Phe Phe 
                85                  90                  95      

Leu Leu Ser Lys Leu Asn Ala Leu Gln Asn Val Glu Leu Pro Leu Ile 
            100                 105                 110         

Tyr Ala Gly Val Ser Ser Ser Lys Arg Arg Lys Leu Ala Glu Glu Tyr 
        115                 120                 125             

Leu Asp Lys Val Glu Leu Thr Glu Arg Ser His His Leu Pro Ser Glu 
    130                 135                 140                 

Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Val 
145                 150                 155                 160 

Asn Asn Pro Ser Ile Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp 
                165                 170                 175     

Thr Lys Thr Gly Asn Gln Ile Met Gln Leu Leu Val Asp Leu Asn Lys 
            180                 185                 190         

Glu Gly Lys Thr Ile Ile Met Val Thr His Glu Pro Glu Ile Ala Ala 
        195                 200                 205             

Tyr Ala Lys Arg Gln Ile Val Ile Arg Asp Gly Val Ile Ser Ser Asp 
    210                 215                 220                 

Ser Ala Gln Leu Gly Lys Glu Glu Asn 
225                 230             

<210>   1495
<211>   1257
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1495
atgcagaatc tgaaatttgc cttttcatct atcatggctc acaagatgcg ttctttgctt   60
actatgattg ggattattat cggtgtttca tcagttgttg tgattatggc tttgggtgat   120
tccctatctc gtcaagtcaa taaagatatg actaaatctc agaaaaatat tagcgtcttt   180
ttctctccta aaaaaagtaa agacgggtct tttactcaga aacaatcagc ttttacggtt   240
tctggaaagg aagaggaagt tcctgttgaa ccgccaaaac cgcaagaatc ctgggtccaa   300
gaggcagcta aactgaaggg agtggatagt tactatgtaa ccaattcaac gaatgccatc   360
ttgacctatc aagataaaaa ggttgagaat gctaatttga caggtggaaa cagaacttac   420
atggacgctg ttaagaatga aattattgca ggtcgtagtc tgagagagca agatttcaaa   480
gagtttgcaa gtgtcatttt gctagatgag gaattgtcca ttagtttatt tgaatctcct   540
caagaggcta ttaacaaggt tgtagaagtc aatggattta gttaccgggt cattggggtt   600
tatactagtc cggaggctaa aagatcaaaa atatatgggt ttggtggctt gcctattact   660
accaatatct cccttgctgc gaattttaat gtagatgaaa tagctaatat tgtctttcga   720
gtgaatgata ccagtttaac cccaactctg ggtccagaac tggcacgaaa aatgacagag   780
cttgcaggct tacaacaggg agaataccag gtggcagatg agtccgttgt atttgcagaa   840
attcaacaat cgtttagttt tatgacgacg attattagtt ccatcgcagg gatttctctc   900
tttgttggag gaactggtgt catgaacatc atgctggttt cggtgacaga gcgcactcgt   960
gagattggtc ttcgtaaggc tttgggtgca acacgtgcca atattttaat tcagtttttg   1020
attgaatcca tgattttgac cttgttaggt ggcttaattg gcttgacaat tgcaagtggt   1080
ttaactgcct tagcaggttt gttactgcaa ggtttaatag aaggtataga agttggagta   1140
tcaatcccag tcgccctatt tagtcttgca gtttcggcta gtgttggtat gatttttgga   1200
gtcttgccag ccaacaaggc atcgaaactt gatccaattg aagcccttcg ttatgaa      1257

<210>   1496
<211>   419
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902739 (0.E+01)

<400>   1496
Met Gln Asn Leu Lys Phe Ala Phe Ser Ser Ile Met Ala His Lys Met 
1               5                   10                  15      

Arg Ser Leu Leu Thr Met Ile Gly Ile Ile Ile Gly Val Ser Ser Val 
            20                  25                  30          


Val Val Ile Met Ala Leu Gly Asp Ser Leu Ser Arg Gln Val Asn Lys 
        35                  40                  45              

Asp Met Thr Lys Ser Gln Lys Asn Ile Ser Val Phe Phe Ser Pro Lys 
    50                  55                  60                  

Lys Ser Lys Asp Gly Ser Phe Thr Gln Lys Gln Ser Ala Phe Thr Val 
65                  70                  75                  80  

Ser Gly Lys Glu Glu Glu Val Pro Val Glu Pro Pro Lys Pro Gln Glu 
                85                  90                  95      

Ser Trp Val Gln Glu Ala Ala Lys Leu Lys Gly Val Asp Ser Tyr Tyr 
            100                 105                 110         

Val Thr Asn Ser Thr Asn Ala Ile Leu Thr Tyr Gln Asp Lys Lys Val 
        115                 120                 125             

Glu Asn Ala Asn Leu Thr Gly Gly Asn Arg Thr Tyr Met Asp Ala Val 
    130                 135                 140                 

Lys Asn Glu Ile Ile Ala Gly Arg Ser Leu Arg Glu Gln Asp Phe Lys 
145                 150                 155                 160 

Glu Phe Ala Ser Val Ile Leu Leu Asp Glu Glu Leu Ser Ile Ser Leu 
                165                 170                 175     

Phe Glu Ser Pro Gln Glu Ala Ile Asn Lys Val Val Glu Val Asn Gly 
            180                 185                 190         

Phe Ser Tyr Arg Val Ile Gly Val Tyr Thr Ser Pro Glu Ala Lys Arg 
        195                 200                 205             

Ser Lys Ile Tyr Gly Phe Gly Gly Leu Pro Ile Thr Thr Asn Ile Ser 
    210                 215                 220                 

Leu Ala Ala Asn Phe Asn Val Asp Glu Ile Ala Asn Ile Val Phe Arg 
225                 230                 235                 240 

Val Asn Asp Thr Ser Leu Thr Pro Thr Leu Gly Pro Glu Leu Ala Arg 
                245                 250                 255     

Lys Met Thr Glu Leu Ala Gly Leu Gln Gln Gly Glu Tyr Gln Val Ala 
            260                 265                 270         

Asp Glu Ser Val Val Phe Ala Glu Ile Gln Gln Ser Phe Ser Phe Met 
        275                 280                 285             

Thr Thr Ile Ile Ser Ser Ile Ala Gly Ile Ser Leu Phe Val Gly Gly 
    290                 295                 300                 

Thr Gly Val Met Asn Ile Met Leu Val Ser Val Thr Glu Arg Thr Arg 
305                 310                 315                 320 

Glu Ile Gly Leu Arg Lys Ala Leu Gly Ala Thr Arg Ala Asn Ile Leu 
                325                 330                 335     

Ile Gln Phe Leu Ile Glu Ser Met Ile Leu Thr Leu Leu Gly Gly Leu 
            340                 345                 350         

Ile Gly Leu Thr Ile Ala Ser Gly Leu Thr Ala Leu Ala Gly Leu Leu 
        355                 360                 365             

Leu Gln Gly Leu Ile Glu Gly Ile Glu Val Gly Val Ser Ile Pro Val 
    370                 375                 380                 

Ala Leu Phe Ser Leu Ala Val Ser Ala Ser Val Gly Met Ile Phe Gly 
385                 390                 395                 400 

Val Leu Pro Ala Asn Lys Ala Ser Lys Leu Asp Pro Ile Glu Ala Leu 
                405                 410                 415     

Arg Tyr Glu 
            

<210>   1497
<211>   1995
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1497
atgtctgaaa aaaattttta tattacaacg ccgatttact atccatctgg gaaacttcat   60
atcggttctg cctacacaac tatcgcatgt gatgtcctag cacgttacaa acgcctgatg   120
ggctacgatg tattttatct gacaggtctt gatgaacatg gtcagaaaat ccagcagaaa   180
gcggaagaag ctggtattac acctcaagcc tatgttgatg gaatggcggt tggagttaaa   240
gaactctggc aattactaga tatctcatac gataaattta tccgtacaac tgatgactac   300
catgaaaaag ttgtcgcaca agtctttgaa cgcttacttg ctcaagatga tatctacttg   360
ggtgaatact ctggttggta ttcagtatca gacgaagaat tctttacaga aagccagctg   420
gcagaagttt tccgtgatga agctggaaat gtgactggtg gtattgctcc atcaggtcat   480
gaggttgaat gggtttctga agaatcatac ttccttcgcc ttagcaaata ccaagaccgt   540
ttggtcgaat ttttcaaagc tcatcctgaa tttatcacgc cagatggtcg ccttaatgaa   600
atgctacgca acttcatcga gccaggcttg gaagatttgg cggtatctcg tacaaccttt   660
acatggggag tgcctgtccc atcaaatcca aaacacgttg tctacgtttg gattgatgcc   720
cttcttaact atgcgacagc tcttggctac gctcaagacg aacatggtaa ctttgacaag   780
ttctggaatg gaacagtctt ccatatggta ggaaaagata tccttcgctt ccactctatc   840
tactggccaa tccttcttat gatgttggat gttaaattac ctgatcgttt gattgcccat   900
ggttggtttg tcatgaaaga cggaaaaatg tctaagtcaa aagggaatgt cgtttaccct   960
gaaatgttgg tagagcgtta tggactagat ccacttcgtt actacctcat gcgtaacctt   1020
ccagttggtt cagacggaac ctttactcct gaagactatg tcggccgtat caactatgaa   1080
ttggctaatg accttgggaa cctccttaac cgtacggttt ccatgattaa taagtacttt   1140
gatggacaaa tccctgccta tgtagaaggt gtgactgaat ttgatcatgt tcttgctgag   1200
gttgcagaac aatcaatcgc agacttccat acacacatgg aagcagttga ctatccacgt   1260
gcgcttgaag cagtctggac tctgatctct cgtaccaata aatacatcga tgagaccgca   1320
ccatgggtct tggccaagga tgaagctctt cgtgaccaat tggcaagtgt catgagccac   1380
ttggcagcca gcattcgtgt agttgctcac ttgattgaac catttatgat ggaaactagt   1440
cgtgcagttt tgactcaact tggtttggaa gaagtttcta gtcttgaaaa cttgagtttg   1500
gctgacttcc cagcagatgt gactgtagtt gccaaaggaa cacctatctt tccacgtcta   1560
aatatggaag aagaaatcgc ctatatcaag gaacaaatgg aaggcaataa accagcagtc   1620
gaaaaagaat ggaatccgga cgaagttgag ctcaaactaa acaaggatga aatcaagttt   1680
gaagactttg acaaggttga aatccgtgtc gcagaagtca aagaagtgtc taaagtagaa   1740
ggttcagata agttgcttca attccgcttg gatgctggtg atggagaaga tcgtcagatt   1800
ctttcaggaa ttgcaaaata ctatccaaat gaacaagaat tggtcggcaa gaaagttcaa   1860
atcgttgcta acctcaaacc acgtaaaatg atgaaaaaat atgtcagcca gggtatgatt   1920
ctctcagctg aacatgatgg caaattaacc cttctcacag ttgatccagc tgtaccaaat   1980
ggaagtgtga ttggg                                                    1995

<210>   1498
<211>   665
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   methionyl-tRNA synthetase (metG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902740 (0.E+01)

<400>   1498
Met Ser Glu Lys Asn Phe Tyr Ile Thr Thr Pro Ile Tyr Tyr Pro Ser 
1               5                   10                  15      

Gly Lys Leu His Ile Gly Ser Ala Tyr Thr Thr Ile Ala Cys Asp Val 
            20                  25                  30          

Leu Ala Arg Tyr Lys Arg Leu Met Gly Tyr Asp Val Phe Tyr Leu Thr 
        35                  40                  45              

Gly Leu Asp Glu His Gly Gln Lys Ile Gln Gln Lys Ala Glu Glu Ala 
    50                  55                  60                  

Gly Ile Thr Pro Gln Ala Tyr Val Asp Gly Met Ala Val Gly Val Lys 
65                  70                  75                  80  

Glu Leu Trp Gln Leu Leu Asp Ile Ser Tyr Asp Lys Phe Ile Arg Thr 
                85                  90                  95      

Thr Asp Asp Tyr His Glu Lys Val Val Ala Gln Val Phe Glu Arg Leu 
            100                 105                 110         

Leu Ala Gln Asp Asp Ile Tyr Leu Gly Glu Tyr Ser Gly Trp Tyr Ser 
        115                 120                 125             

Val Ser Asp Glu Glu Phe Phe Thr Glu Ser Gln Leu Ala Glu Val Phe 
    130                 135                 140                 

Arg Asp Glu Ala Gly Asn Val Thr Gly Gly Ile Ala Pro Ser Gly His 
145                 150                 155                 160 

Glu Val Glu Trp Val Ser Glu Glu Ser Tyr Phe Leu Arg Leu Ser Lys 
                165                 170                 175     

Tyr Gln Asp Arg Leu Val Glu Phe Phe Lys Ala His Pro Glu Phe Ile 
            180                 185                 190         

Thr Pro Asp Gly Arg Leu Asn Glu Met Leu Arg Asn Phe Ile Glu Pro 
        195                 200                 205             

Gly Leu Glu Asp Leu Ala Val Ser Arg Thr Thr Phe Thr Trp Gly Val 
    210                 215                 220                 

Pro Val Pro Ser Asn Pro Lys His Val Val Tyr Val Trp Ile Asp Ala 
225                 230                 235                 240 

Leu Leu Asn Tyr Ala Thr Ala Leu Gly Tyr Ala Gln Asp Glu His Gly 
                245                 250                 255     

Asn Phe Asp Lys Phe Trp Asn Gly Thr Val Phe His Met Val Gly Lys 
            260                 265                 270         

Asp Ile Leu Arg Phe His Ser Ile Tyr Trp Pro Ile Leu Leu Met Met 
        275                 280                 285             

Leu Asp Val Lys Leu Pro Asp Arg Leu Ile Ala His Gly Trp Phe Val 
    290                 295                 300                 

Met Lys Asp Gly Lys Met Ser Lys Ser Lys Gly Asn Val Val Tyr Pro 
305                 310                 315                 320 

Glu Met Leu Val Glu Arg Tyr Gly Leu Asp Pro Leu Arg Tyr Tyr Leu 
                325                 330                 335     

Met Arg Asn Leu Pro Val Gly Ser Asp Gly Thr Phe Thr Pro Glu Asp 
            340                 345                 350         

Tyr Val Gly Arg Ile Asn Tyr Glu Leu Ala Asn Asp Leu Gly Asn Leu 
        355                 360                 365             

Leu Asn Arg Thr Val Ser Met Ile Asn Lys Tyr Phe Asp Gly Gln Ile 
    370                 375                 380                 

Pro Ala Tyr Val Glu Gly Val Thr Glu Phe Asp His Val Leu Ala Glu 
385                 390                 395                 400 

Val Ala Glu Gln Ser Ile Ala Asp Phe His Thr His Met Glu Ala Val 
                405                 410                 415     

Asp Tyr Pro Arg Ala Leu Glu Ala Val Trp Thr Leu Ile Ser Arg Thr 
            420                 425                 430         

Asn Lys Tyr Ile Asp Glu Thr Ala Pro Trp Val Leu Ala Lys Asp Glu 
        435                 440                 445             

Ala Leu Arg Asp Gln Leu Ala Ser Val Met Ser His Leu Ala Ala Ser 
    450                 455                 460                 

Ile Arg Val Val Ala His Leu Ile Glu Pro Phe Met Met Glu Thr Ser 
465                 470                 475                 480 

Arg Ala Val Leu Thr Gln Leu Gly Leu Glu Glu Val Ser Ser Leu Glu 
                485                 490                 495     

Asn Leu Ser Leu Ala Asp Phe Pro Ala Asp Val Thr Val Val Ala Lys 
            500                 505                 510         

Gly Thr Pro Ile Phe Pro Arg Leu Asn Met Glu Glu Glu Ile Ala Tyr 
        515                 520                 525             

Ile Lys Glu Gln Met Glu Gly Asn Lys Pro Ala Val Glu Lys Glu Trp 
    530                 535                 540                 

Asn Pro Asp Glu Val Glu Leu Lys Leu Asn Lys Asp Glu Ile Lys Phe 
545                 550                 555                 560 

Glu Asp Phe Asp Lys Val Glu Ile Arg Val Ala Glu Val Lys Glu Val 
                565                 570                 575     

Ser Lys Val Glu Gly Ser Asp Lys Leu Leu Gln Phe Arg Leu Asp Ala 
            580                 585                 590         

Gly Asp Gly Glu Asp Arg Gln Ile Leu Ser Gly Ile Ala Lys Tyr Tyr 
        595                 600                 605             

Pro Asn Glu Gln Glu Leu Val Gly Lys Lys Val Gln Ile Val Ala Asn 
    610                 615                 620                 

Leu Lys Pro Arg Lys Met Met Lys Lys Tyr Val Ser Gln Gly Met Ile 
625                 630                 635                 640 

Leu Ser Ala Glu His Asp Gly Lys Leu Thr Leu Leu Thr Val Asp Pro 
                645                 650                 655     

Ala Val Pro Asn Gly Ser Val Ile Gly 
            660                 665 

<210>   1499
<211>   324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1499
atgaaaatca aagagcaaac taggaagcta gccgcaggtt gctcaaaaca ctgttttgag   60
gttgtagacg aaactgacga agtcagctca aaacatgttt ttgaggttgt agatgaaact   120
gacgaagtca gctcaaaaca ctgttttgag gttgtagatg aaactgacga agtcagctca   180
aaacactgtt ttgaggttgt agatgaaact gacgaagtca gctcaaaaca tgtttttgag   240
gttgtagatg aaactgacga agtcagtaac catacatacg gtagggcgac gctgacgtgg   300
tttgaagaga ttttcgaaga gtat                                          324

<210>   1500
<211>   108
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1500
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Val Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Ser Lys His Cys 
        35                  40                  45              

Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Ser Lys His Cys Phe 
    50                  55                  60                  

Glu Val Val Asp Glu Thr Asp Glu Val Ser Ser Lys His Val Phe Glu 
65                  70                  75                  80  

Val Val Asp Glu Thr Asp Glu Val Ser Asn His Thr Tyr Gly Arg Ala 
                85                  90                  95      

Thr Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr 
            100                 105             

<210>   1501
<211>   321
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1501
gtgatgaaag aaactcagct attaaaaggt gttcttgaag gttgtgtctt ggatatgatt   60
ggtcaaaaag agcggtatgg ttatgagttg gttcagactt tgcgagaggc tggatttgat   120
actatcgttc caggaactat ttatcctttg ttgcaaaagt tagaaaaaaa tcaatggata   180
agaggcgaca tgcgcccgtc gccagatggt ccagatcgga agtatttttc attaatgaaa   240
gaaggagaag agcgtgtctc agtcttttgg caacaatggg acgatttgag tcaaaaagta   300
gaagggatta agaatggggg t                                             321

<210>   1502
<211>   107
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15902741 (4.E-60)

<400>   1502
Met Met Lys Glu Thr Gln Leu Leu Lys Gly Val Leu Glu Gly Cys Val 
1               5                   10                  15      

Leu Asp Met Ile Gly Gln Lys Glu Arg Tyr Gly Tyr Glu Leu Val Gln 
            20                  25                  30          

Thr Leu Arg Glu Ala Gly Phe Asp Thr Ile Val Pro Gly Thr Ile Tyr 
        35                  40                  45              

Pro Leu Leu Gln Lys Leu Glu Lys Asn Gln Trp Ile Arg Gly Asp Met 
    50                  55                  60                  

Arg Pro Ser Pro Asp Gly Pro Asp Arg Lys Tyr Phe Ser Leu Met Lys 
65                  70                  75                  80  

Glu Gly Glu Glu Arg Val Ser Val Phe Trp Gln Gln Trp Asp Asp Leu 
                85                  90                  95      

Ser Gln Lys Val Glu Gly Ile Lys Asn Gly Gly 
            100                 105         

<210>   1503
<211>   813
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1503
atgaagaaaa tgaagtatta cgaagaaaca agcgctttgc tacatgagtt ttctgaggag   60
aatcaaaagt attttgagga gttgtgggaa agttttaatc ttgctggatt tctctatgat   120
gaagactatc tcagagagca gatctatttg atgatgctag atttctcaga agcagaacga   180
gatggcatga gtgcagagga ttatctaggt aagaatccta aaaaaataat gaaagagatt   240
ctcaagggag cacctcgcag ttctatcaaa gagtcccttt tgacgccaat tcttgtcctg   300
gcggtattac gttattatca actactaagt gatttttcta aaggtcctct cttaacagtc   360
aatttgctca catttttagg gcaacttctt atttttctga ttggatttgg acttgtggcc   420
acaattttac gaagaagttt agtccaagat tctcctaaaa tgaaaattgg cacttacatt   480
gttgttggga ctatagttct tctagttgtt ttaggatatg taggaatggc aagcttcata   540
caagaaggag ccttttatat tccggctccc tgggatagtt tgtctgtctt tacgatttcg   600
ctagttatcg gtatttggaa ttggaaagaa gcggtctttc gtccatttgt cagtatgatt   660
attgcccatc ttgtggtggg ttctctgctc cgttattatg agtggatggg aatttcaaat   720
gttttcctta caaaagttat tcctttagct gtcctcttta ttggaatctt tgtcttgttc   780
cgtgggttta agaagataaa atggagtgaa gta                                813

<210>   1504
<211>   271
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902742 (e-153)

<400>   1504
Met Lys Lys Met Lys Tyr Tyr Glu Glu Thr Ser Ala Leu Leu His Glu 
1               5                   10                  15      

Phe Ser Glu Glu Asn Gln Lys Tyr Phe Glu Glu Leu Trp Glu Ser Phe 
            20                  25                  30          

Asn Leu Ala Gly Phe Leu Tyr Asp Glu Asp Tyr Leu Arg Glu Gln Ile 
        35                  40                  45              

Tyr Leu Met Met Leu Asp Phe Ser Glu Ala Glu Arg Asp Gly Met Ser 
    50                  55                  60                  

Ala Glu Asp Tyr Leu Gly Lys Asn Pro Lys Lys Ile Met Lys Glu Ile 
65                  70                  75                  80  

Leu Lys Gly Ala Pro Arg Ser Ser Ile Lys Glu Ser Leu Leu Thr Pro 
                85                  90                  95      

Ile Leu Val Leu Ala Val Leu Arg Tyr Tyr Gln Leu Leu Ser Asp Phe 
            100                 105                 110         

Ser Lys Gly Pro Leu Leu Thr Val Asn Leu Leu Thr Phe Leu Gly Gln 
        115                 120                 125             

Leu Leu Ile Phe Leu Ile Gly Phe Gly Leu Val Ala Thr Ile Leu Arg 
    130                 135                 140                 

Arg Ser Leu Val Gln Asp Ser Pro Lys Met Lys Ile Gly Thr Tyr Ile 
145                 150                 155                 160 

Val Val Gly Thr Ile Val Leu Leu Val Val Leu Gly Tyr Val Gly Met 
                165                 170                 175     

Ala Ser Phe Ile Gln Glu Gly Ala Phe Tyr Ile Pro Ala Pro Trp Asp 
            180                 185                 190         

Ser Leu Ser Val Phe Thr Ile Ser Leu Val Ile Gly Ile Trp Asn Trp 
        195                 200                 205             

Lys Glu Ala Val Phe Arg Pro Phe Val Ser Met Ile Ile Ala His Leu 
    210                 215                 220                 

Val Val Gly Ser Leu Leu Arg Tyr Tyr Glu Trp Met Gly Ile Ser Asn 
225                 230                 235                 240 

Val Phe Leu Thr Lys Val Ile Pro Leu Ala Val Leu Phe Ile Gly Ile 
                245                 250                 255     

Phe Val Leu Phe Arg Gly Phe Lys Lys Ile Lys Trp Ser Glu Val 
            260                 265                 270     

<210>   1505
<211>   924
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1505
atgagataca taactcttgg tcaagatgac aaagaattat cagaaattgt tctcggaatg   60
atgagaataa aagataaatc tgtaaaagaa gttgaagagc ttgtagaaac agcactttct   120
gttggaatca atgccttcga cttggctgat atttatggtc gtggtcgttg tgaagaactg   180
ttaggtcttg tcctaaaaaa tcgtccagat ttaagagaaa agatgtggat tcagtccaaa   240
tgtggcattc gcattgaaga atttacctat tttgattttt ctaaggacta tattataaaa   300
tcagtagacg gtattttgca aagattgaag attgatcatc tagatagctt gctccttcat   360
cgaccagatg ctttgatgga atctgaccaa gtagcagaag cctttaatct cctttataaa   420
caaggtaaag ttcgagattt tggagtttct aatcaaaatc ctatgatgat ggagttgctt   480
aaaaaagatg tcaagcagcc gttagctgtt aatcagctac aattgagtgc ggcttttact   540
ccaggatttg aatcagcttt tcatgttaat atggaagata gtcaagcagc tatgcgagat   600
ggcagcattt ttgaatattg ccaattacac gatgtggtca ttcaagcatg gtctgtctta   660
caattcgggt attttaaagg gaattttgtt ggaaatgaga aatttcaagc tttaaatcaa   720
gtacttgatc gtttagctat taaatatgga gtaacctctt caactattgc catttcttgg   780
atattgcgtt atccagcaaa aatgcaggca gtcgtaggta caacaaatcc taagcacttg   840
agagaagtta gccgagcggc aaactttagc ttaacaagaa aagaatggta tgaaatttat   900
cttgctgcag ggaataattt gccg                                          924

<210>   1506
<211>   308
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, aldo/keto reductase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902743 (e-175)

<400>   1506
Met Arg Tyr Ile Thr Leu Gly Gln Asp Asp Lys Glu Leu Ser Glu Ile 
1               5                   10                  15      

Val Leu Gly Met Met Arg Ile Lys Asp Lys Ser Val Lys Glu Val Glu 
            20                  25                  30          

Glu Leu Val Glu Thr Ala Leu Ser Val Gly Ile Asn Ala Phe Asp Leu 
        35                  40                  45              

Ala Asp Ile Tyr Gly Arg Gly Arg Cys Glu Glu Leu Leu Gly Leu Val 
    50                  55                  60                  

Leu Lys Asn Arg Pro Asp Leu Arg Glu Lys Met Trp Ile Gln Ser Lys 
65                  70                  75                  80  

Cys Gly Ile Arg Ile Glu Glu Phe Thr Tyr Phe Asp Phe Ser Lys Asp 
                85                  90                  95      

Tyr Ile Ile Lys Ser Val Asp Gly Ile Leu Gln Arg Leu Lys Ile Asp 
            100                 105                 110         

His Leu Asp Ser Leu Leu Leu His Arg Pro Asp Ala Leu Met Glu Ser 
        115                 120                 125             

Asp Gln Val Ala Glu Ala Phe Asn Leu Leu Tyr Lys Gln Gly Lys Val 

    130                 135                 140                 

Arg Asp Phe Gly Val Ser Asn Gln Asn Pro Met Met Met Glu Leu Leu 
145                 150                 155                 160 

Lys Lys Asp Val Lys Gln Pro Leu Ala Val Asn Gln Leu Gln Leu Ser 
                165                 170                 175     

Ala Ala Phe Thr Pro Gly Phe Glu Ser Ala Phe His Val Asn Met Glu 
            180                 185                 190         

Asp Ser Gln Ala Ala Met Arg Asp Gly Ser Ile Phe Glu Tyr Cys Gln 
        195                 200                 205             

Leu His Asp Val Val Ile Gln Ala Trp Ser Val Leu Gln Phe Gly Tyr 
    210                 215                 220                 

Phe Lys Gly Asn Phe Val Gly Asn Glu Lys Phe Gln Ala Leu Asn Gln 
225                 230                 235                 240 

Val Leu Asp Arg Leu Ala Ile Lys Tyr Gly Val Thr Ser Ser Thr Ile 
                245                 250                 255     

Ala Ile Ser Trp Ile Leu Arg Tyr Pro Ala Lys Met Gln Ala Val Val 
            260                 265                 270         

Gly Thr Thr Asn Pro Lys His Leu Arg Glu Val Ser Arg Ala Ala Asn 
        275                 280                 285             

Phe Ser Leu Thr Arg Lys Glu Trp Tyr Glu Ile Tyr Leu Ala Ala Gly 
    290                 295                 300                 

Asn Asn Leu Pro 
305             

<210>   1507
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1507

atgaagaatg tagaattaaa ggagaaaaac atgacatttg aagagatcct gcctgggtta   60
aaggctaaga gaaaatatgt acgaactggt tggggaggtg cggaaaacta tgtccaactc   120
tttgatacca tcgagcaaaa tgggcttgca cttgaaatga caccttattt cctaatcaac   180
gtttctggcg aaggagaagg tttttccatg tggagcccga cagtttgtga tgttttggca   240
acggattggg tagaagtgca tgac                                          264

<210>   1508
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902744 (3.E-45)

<400>   1508
Met Lys Asn Val Glu Leu Lys Glu Lys Asn Met Thr Phe Glu Glu Ile 
1               5                   10                  15      

Leu Pro Gly Leu Lys Ala Lys Arg Lys Tyr Val Arg Thr Gly Trp Gly 
            20                  25                  30          

Gly Ala Glu Asn Tyr Val Gln Leu Phe Asp Thr Ile Glu Gln Asn Gly 
        35                  40                  45              

Leu Ala Leu Glu Met Thr Pro Tyr Phe Leu Ile Asn Val Ser Gly Glu 
    50                  55                  60                  

Gly Glu Gly Phe Ser Met Trp Ser Pro Thr Val Cys Asp Val Leu Ala 
65                  70                  75                  80  

Thr Asp Trp Val Glu Val His Asp 
                85              

<210>   1509
<211>   696
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1509
atgactaaac gtgtactcat tacaggagtg agttcaggga tcggattggc tcaagctcgc   60
ctctttttag agaagggcta tcaagtttat ggagttgacc aaggtgaaaa gccactctta   120
gagggtgatt ttcgcttttt acagagagat ttgaccttgg acttggaacc tatttttgac   180
tggtgccctc aggtggatgt tttgtgtaat actgctggag ttttggatga ttacaaacca   240
ctgttggaac aaacggcgca ggacattcaa gagatttttg aaatcaacta cattattcca   300
gtagagttga ctcggtatta tttgacacaa atgctggaaa ataaaaaggg aatcatcatc   360
aatatgtgtt ccattgcttc tagcctagca ggtggaggtg gtcacgccta tacttcatcc   420
aagcatgcct tggctggctt caccaagcag ttggctctag actatgctga agctgggatt   480
caggtctttg gtatcgctcc aggagcagtc aagacagcta tgaccgctgc ggattttgaa   540
ccaggtggtt tggctgactg ggtggctagt gaaaccccaa tcaagcgctg gattgagcca   600
gaggaaatag cagagcttag tcttttttta gcaagtggaa aagcgagcgc catgcaagga   660
caaatcttga caatagatgg tggctggtct ttgaag                             696

<210>   1510
<211>   232
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, short chain dehydrogenase/reductase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902745 (e-132)

<400>   1510
Met Thr Lys Arg Val Leu Ile Thr Gly Val Ser Ser Gly Ile Gly Leu 
1               5                   10                  15      

Ala Gln Ala Arg Leu Phe Leu Glu Lys Gly Tyr Gln Val Tyr Gly Val 
            20                  25                  30          

Asp Gln Gly Glu Lys Pro Leu Leu Glu Gly Asp Phe Arg Phe Leu Gln 
        35                  40                  45              

Arg Asp Leu Thr Leu Asp Leu Glu Pro Ile Phe Asp Trp Cys Pro Gln 
    50                  55                  60                  

Val Asp Val Leu Cys Asn Thr Ala Gly Val Leu Asp Asp Tyr Lys Pro 
65                  70                  75                  80  

Leu Leu Glu Gln Thr Ala Gln Asp Ile Gln Glu Ile Phe Glu Ile Asn 
                85                  90                  95      

Tyr Ile Ile Pro Val Glu Leu Thr Arg Tyr Tyr Leu Thr Gln Met Leu 
            100                 105                 110         

Glu Asn Lys Lys Gly Ile Ile Ile Asn Met Cys Ser Ile Ala Ser Ser 
        115                 120                 125             

Leu Ala Gly Gly Gly Gly His Ala Tyr Thr Ser Ser Lys His Ala Leu 
    130                 135                 140                 

Ala Gly Phe Thr Lys Gln Leu Ala Leu Asp Tyr Ala Glu Ala Gly Ile 
145                 150                 155                 160 

Gln Val Phe Gly Ile Ala Pro Gly Ala Val Lys Thr Ala Met Thr Ala 
                165                 170                 175     


Ala Asp Phe Glu Pro Gly Gly Leu Ala Asp Trp Val Ala Ser Glu Thr 
            180                 185                 190         

Pro Ile Lys Arg Trp Ile Glu Pro Glu Glu Ile Ala Glu Leu Ser Leu 
        195                 200                 205             

Phe Leu Ala Ser Gly Lys Ala Ser Ala Met Gln Gly Gln Ile Leu Thr 
    210                 215                 220                 

Ile Asp Gly Gly Trp Ser Leu Lys 
225                 230         

<210>   1511
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1511
ttggggtcta ctgtgtttgc tttgaaaatg gaaagttact ttgcattgaa aaaacgagag   60
gcccttatca acatcggtat gatctacctg gaggcagtca gcaacttggt gaaggac      117

<210>   1512
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1512
Met Gly Ser Thr Val Phe Ala Leu Lys Met Glu Ser Tyr Phe Ala Leu 
1               5                   10                  15      

Lys Lys Arg Glu Ala Leu Ile Asn Ile Gly Met Ile Tyr Leu Glu Ala 
            20                  25                  30          

Val Ser Asn Leu Val Lys Asp 
        35                  

<210>   1513
<211>   498
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1513
atggaaatca aaaatcactt tggggtctac tgtgtttgct ttgaaaatgg aaagttactt   60
tgcattgaaa aaacgagagg cccttatcaa catcggtatg atctacctgg aggcagtcag   120
caacttggtg aaggactgac ggaaacgctg actagagaag ttatggaaga gacgggattt   180
actgttagaa gctactctaa tcctcgaatc tacgatgttt tcgtcaggga agagttaaaa   240
aattttatgg ttcaccatgt catagccttg tatgatgttg aaatgaatga gagtgcacct   300
caagttacga tttcggaagc tgtgtctgat ggtgcgaatg attcacttgg atatatttgg   360
atggatattc aagagattac agaagaaaat gcatcgccat tagtcttgaa ggttaagtct   420
gaattattag gatttccaga actggacaag acttcttaca tgaattggaa ggtgaatgat   480
gagaaatcaa cttgccct                                                 498

<210>   1514
<211>   166
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MutT/nudix family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902746 (9.E-91)

<400>   1514
Met Glu Ile Lys Asn His Phe Gly Val Tyr Cys Val Cys Phe Glu Asn 
1               5                   10                  15      

Gly Lys Leu Leu Cys Ile Glu Lys Thr Arg Gly Pro Tyr Gln His Arg 
            20                  25                  30          

Tyr Asp Leu Pro Gly Gly Ser Gln Gln Leu Gly Glu Gly Leu Thr Glu 
        35                  40                  45              

Thr Leu Thr Arg Glu Val Met Glu Glu Thr Gly Phe Thr Val Arg Ser 
    50                  55                  60                  

Tyr Ser Asn Pro Arg Ile Tyr Asp Val Phe Val Arg Glu Glu Leu Lys 
65                  70                  75                  80  

Asn Phe Met Val His His Val Ile Ala Leu Tyr Asp Val Glu Met Asn 
                85                  90                  95      

Glu Ser Ala Pro Gln Val Thr Ile Ser Glu Ala Val Ser Asp Gly Ala 
            100                 105                 110         

Asn Asp Ser Leu Gly Tyr Ile Trp Met Asp Ile Gln Glu Ile Thr Glu 
        115                 120                 125             

Glu Asn Ala Ser Pro Leu Val Leu Lys Val Lys Ser Glu Leu Leu Gly 
    130                 135                 140                 

Phe Pro Glu Leu Asp Lys Thr Ser Tyr Met Asn Trp Lys Val Asn Asp 
145                 150                 155                 160 

Glu Lys Ser Thr Cys Pro 
                165     

<210>   1515
<211>   792
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1515
atgattcgtg gggaatactt attgagagag ctcaatcaaa atatactatt acaaagttgt   60
caggaatttg tgaaagatta tcttgatact atttgctcct tttacttagg taaggaagtt   120
tggtatcgtt ttactgaatt aacgaataca gaagccaatt gtttagtggg gactaaagag   180
ttttttgacg aagggcatcc cttgtttggc tatagaggaa ctaggcgttt actggcgtgt   240
ttggatgaat ttcaggctga agcacatgtc gttacagaag tttatcaaac caaccccaat   300
ctatctgtta tctttccttt tgtcaatgat gccgaccaat taaaacaagc tattacagta   360
ttgcgtcagc agggttttac tgggaaagtc ggaacgatga ttgaattacc gtcagcgtat   420
tttgacttat ctagtatact ggaaacgggc atttcaaaga ttgtagttgg aatgaatgat   480
ttgacttcct ttgtttttgc gactatgaga aacagtcaat ggcatgatat ggaaagtcca   540
ataatgttag atatgctaag agatatgcag gataaagcaa gaaagaacaa gattgatttt   600
gctgtagcag gctatctgaa tacttctttc atacaaaaaa tgaatcagtt gggtatcaag   660
tgcattatcc actacagttc tattccagag atttttgatt tagagattga ccatccagat   720
catcttaaac acataaaaga agaaagtaaa aaattacaaa ggagcaccca tgataccgca   780
agaaatgtgg aa                                                       792

<210>   1516
<211>   264
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PEP-utilizing enzymes family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902748 (e-152)

<400>   1516
Met Ile Arg Gly Glu Tyr Leu Leu Arg Glu Leu Asn Gln Asn Ile Leu 
1               5                   10                  15      

Leu Gln Ser Cys Gln Glu Phe Val Lys Asp Tyr Leu Asp Thr Ile Cys 
            20                  25                  30          

Ser Phe Tyr Leu Gly Lys Glu Val Trp Tyr Arg Phe Thr Glu Leu Thr 
        35                  40                  45              

Asn Thr Glu Ala Asn Cys Leu Val Gly Thr Lys Glu Phe Phe Asp Glu 
    50                  55                  60                  

Gly His Pro Leu Phe Gly Tyr Arg Gly Thr Arg Arg Leu Leu Ala Cys 
65                  70                  75                  80  

Leu Asp Glu Phe Gln Ala Glu Ala His Val Val Thr Glu Val Tyr Gln 
                85                  90                  95      

Thr Asn Pro Asn Leu Ser Val Ile Phe Pro Phe Val Asn Asp Ala Asp 
            100                 105                 110         

Gln Leu Lys Gln Ala Ile Thr Val Leu Arg Gln Gln Gly Phe Thr Gly 
        115                 120                 125             

Lys Val Gly Thr Met Ile Glu Leu Pro Ser Ala Tyr Phe Asp Leu Ser 
    130                 135                 140                 

Ser Ile Leu Glu Thr Gly Ile Ser Lys Ile Val Val Gly Met Asn Asp 
145                 150                 155                 160 

Leu Thr Ser Phe Val Phe Ala Thr Met Arg Asn Ser Gln Trp His Asp 
                165                 170                 175     

Met Glu Ser Pro Ile Met Leu Asp Met Leu Arg Asp Met Gln Asp Lys 
            180                 185                 190         

Ala Arg Lys Asn Lys Ile Asp Phe Ala Val Ala Gly Tyr Leu Asn Thr 
        195                 200                 205             

Ser Phe Ile Gln Lys Met Asn Gln Leu Gly Ile Lys Cys Ile Ile His 
    210                 215                 220                 

Tyr Ser Ser Ile Pro Glu Ile Phe Asp Leu Glu Ile Asp His Pro Asp 
225                 230                 235                 240 

His Leu Lys His Ile Lys Glu Glu Ser Lys Lys Leu Gln Arg Ser Thr 
                245                 250                 255     

His Asp Thr Ala Arg Asn Val Glu 
            260                 

<210>   1517
<211>   438
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1517
atgataccgc aagaaatgtg gaataaatac aagcaaatca atcctttgat cggagatgaa   60
atcgatgcct gggcttttgg agttgaacca gaccttttag cggatttggt gtttaaagga   120
gaaaagacag caacagcatc agcctatgac ctctatgtgc tagaagacga accacttccc   180
caagtaggga ccttcgatgt cattttagat agtcaaaatc aggctgtctg cattgtcgaa   240
attacaaagg tttctgttaa acccttcaat cgagtgtcag ctgaccatgc ctataaggaa   300
ggtgagggaa acaagacact tgtctattgg cgccaggttc atgaggattt tttcagagac   360
tgcttgggtg aagcaggatt gacttttaca cctgaaagca aggttgtttt agaagaattt   420
cgcaaggtct acccactg                                                 438

<210>   1518
<211>   146
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902749 (6.E-78)

<400>   1518
Met Ile Pro Gln Glu Met Trp Asn Lys Tyr Lys Gln Ile Asn Pro Leu 
1               5                   10                  15      

Ile Gly Asp Glu Ile Asp Ala Trp Ala Phe Gly Val Glu Pro Asp Leu 
            20                  25                  30          

Leu Ala Asp Leu Val Phe Lys Gly Glu Lys Thr Ala Thr Ala Ser Ala 
        35                  40                  45              

Tyr Asp Leu Tyr Val Leu Glu Asp Glu Pro Leu Pro Gln Val Gly Thr 
    50                  55                  60                  

Phe Asp Val Ile Leu Asp Ser Gln Asn Gln Ala Val Cys Ile Val Glu 
65                  70                  75                  80  

Ile Thr Lys Val Ser Val Lys Pro Phe Asn Arg Val Ser Ala Asp His 
                85                  90                  95      

Ala Tyr Lys Glu Gly Glu Gly Asn Lys Thr Leu Val Tyr Trp Arg Gln 
            100                 105                 110         

Val His Glu Asp Phe Phe Arg Asp Cys Leu Gly Glu Ala Gly Leu Thr 
        115                 120                 125             

Phe Thr Pro Glu Ser Lys Val Val Leu Glu Glu Phe Arg Lys Val Tyr 
    130                 135                 140                 

Pro Leu 
145     

<210>   1519
<211>   2544
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1519
atgcaagcag ttgaacattt tattaagcaa tttgttcctg aacattatga tttattttta   60
gatttgagtc gtgagaccaa gactttttct gggaaagtga ccatcactgg tcaagcacag   120
agtgaccgca tctccctcca ccaaaaagat ttggaaatca cctctgtaga agttgcaggt   180
caagctcgtc catttacagt tgaccatgac aatgaagccc ttcatatcga attggctgag   240
gctggtcaag ttgaattggt tcttgccttt tctggtaaaa ttacagacaa catgacaggg   300
atttaccctt cttattatac agttgatgga gtcaagaagg aggtcttgtc tactcagttc   360
gagagccatt ttgcgcgcga agctttccca tgtgtggatg agcctgaagc caaagcaact   420
tttgacctct ctcttcgctt tgaccaagca gaaggtgaat tggccttgtc aaacatgcca   480
gaaatcgatg ttgaaaaccg taaggaaaca ggtatctgga agtttgagac aacacctcgc   540
atgtcttctt acttgttggc ctttgttgct ggtgatttgc aaggggtgac cgctaaaact   600
aaaaatggta ccctggtagg tgtctactca accaaagcac atccactttc aaatcttgat   660
ttctcactgg atatcgctgt tcgctctatc gagttttacg aagattacta tggagttaag   720
tacccaattc ctcaatctct ccacatcgcc cttcctgact tctcagctgg tgctatggaa   780
aactggggtc ttgtgaccta ccgtgaagtt tacttggttg tcgatgagaa ctctacattt   840
gctagccgtc aacaagttgc ccttgttgtg gcccatgaat tggctcacca atggtttggg   900
aacctcgtga ctatgaaatg gtgggatgac ctttggctca atgaaagttt cgctaatatg   960
atggaatacg tctgtgtgga taccatcgaa ccaagctgga atatctttga agatttccaa   1020
acaggtggag tacctcttgc tcttgaacgt gacgctactg atggcgttca gtctgtccac   1080
gtcgaagtta aacatccaga tgaaatcaat acactctttg acggcgctat cgtctatgcc   1140
aaaggaagcc gtctcatgca catgcttcgc cgttggctag gagatgctga ttttgctaaa   1200
ggtttgcacg cctactttga aaaacaccaa tacagcaaca ccattggtag tgacctttgg   1260
gatgcccttg gtcaagcgtc aggacgtgat gtcgcagcct tcatggattc ttggttggaa   1320
cagcctggtt acccagttct tactgttaaa gttgaaaatg atgtcttgaa gatttcacaa   1380
aaacaattct tcatcggtga gaacgaagac aagaaccgtc tctgggtggt gcccctcaat   1440
agcaactgga aaggcttgcc tgatacactc gaaactgaaa gtatcgaaat ccctggctac   1500
gcagctcttc ttgctgaaaa tgaaggagct cttcgtctca acactgaaaa tactgcccac   1560
tatattaccg actatcaagg agacttgtta gcagctgttc ttgctgagct agagacactt   1620
gataacacaa gcaaactgca aattgttcaa gaacgtcgtt tgttggctga ggcagggcac   1680
atttcttatg cagacttgct tccagttctt gataaacttg ctaaggaaga gtcttatctg   1740
gtggtttcag ctgtttctca agtgatttca gcccttgagc gctttattga tgaaggaacg   1800
gatgctgaaa cagccttcaa aggactggtt gctaaattgg ctcgtcataa ctatgaccgt   1860
cttggttttg aagctaaaga cggagaatca gatgaggatg aattggttcg tcagctggct   1920
gtttcgatga tgattcgctc aaatgatgca gaagctagtc aagtcgctag ccaaatcttc   1980
gcaacacaca aggagaatct tgcaggactc ccagcagcta ttcgctcaca agttctgatt   2040
aatgagatga aacatcatga gactaaagac ttgttagcac tttatcttga tacttatact   2100
cacgcaacag atgctgtctt taaacgccag ttggcagcag ctcttgcata cagtacagat   2160
gcggataata tccaaaacct gattacttct tggaaggaca aatttgtggt caaaccacag   2220
gacttgtctg cttggtatta ccaattccta gctcatcaag caactcagaa aacagcttgg   2280
tcttgggcgc gtgaaaactg ggcttggatt aaggcagccc ttggaggaga tatgagcttt   2340
gatagctttg ttatccttcc tgctcatgta tttaagactc agcaacgctt ggcggaatac   2400
aaggagttct ttgaaccgca actttctgac cttgctctta gccgtaacat cggtatggga   2460
atcaaggaaa ttgcagcgcg tgttgacttg attagccgtg aaaaagctgc agtcgaagca   2520
gttgttcttc aatacggaaa tgca                                          2544

<210>   1520
<211>   848
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aminopeptidase N (pepN)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902750 (0.E+01)

<400>   1520
Met Gln Ala Val Glu His Phe Ile Lys Gln Phe Val Pro Glu His Tyr 
1               5                   10                  15      

Asp Leu Phe Leu Asp Leu Ser Arg Glu Thr Lys Thr Phe Ser Gly Lys 
            20                  25                  30          

Val Thr Ile Thr Gly Gln Ala Gln Ser Asp Arg Ile Ser Leu His Gln 
        35                  40                  45              

Lys Asp Leu Glu Ile Thr Ser Val Glu Val Ala Gly Gln Ala Arg Pro 
    50                  55                  60                  

Phe Thr Val Asp His Asp Asn Glu Ala Leu His Ile Glu Leu Ala Glu 
65                  70                  75                  80  

Ala Gly Gln Val Glu Leu Val Leu Ala Phe Ser Gly Lys Ile Thr Asp 
                85                  90                  95      

Asn Met Thr Gly Ile Tyr Pro Ser Tyr Tyr Thr Val Asp Gly Val Lys 
            100                 105                 110         

Lys Glu Val Leu Ser Thr Gln Phe Glu Ser His Phe Ala Arg Glu Ala 
        115                 120                 125             

Phe Pro Cys Val Asp Glu Pro Glu Ala Lys Ala Thr Phe Asp Leu Ser 
    130                 135                 140                 

Leu Arg Phe Asp Gln Ala Glu Gly Glu Leu Ala Leu Ser Asn Met Pro 
145                 150                 155                 160 

Glu Ile Asp Val Glu Asn Arg Lys Glu Thr Gly Ile Trp Lys Phe Glu 
                165                 170                 175     

Thr Thr Pro Arg Met Ser Ser Tyr Leu Leu Ala Phe Val Ala Gly Asp 
            180                 185                 190         

Leu Gln Gly Val Thr Ala Lys Thr Lys Asn Gly Thr Leu Val Gly Val 
        195                 200                 205             

Tyr Ser Thr Lys Ala His Pro Leu Ser Asn Leu Asp Phe Ser Leu Asp 
    210                 215                 220                 

Ile Ala Val Arg Ser Ile Glu Phe Tyr Glu Asp Tyr Tyr Gly Val Lys 
225                 230                 235                 240 

Tyr Pro Ile Pro Gln Ser Leu His Ile Ala Leu Pro Asp Phe Ser Ala 
                245                 250                 255     

Gly Ala Met Glu Asn Trp Gly Leu Val Thr Tyr Arg Glu Val Tyr Leu 
            260                 265                 270         

Val Val Asp Glu Asn Ser Thr Phe Ala Ser Arg Gln Gln Val Ala Leu 
        275                 280                 285             

Val Val Ala His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr 
    290                 295                 300                 

Met Lys Trp Trp Asp Asp Leu Trp Leu Asn Glu Ser Phe Ala Asn Met 
305                 310                 315                 320 

Met Glu Tyr Val Cys Val Asp Thr Ile Glu Pro Ser Trp Asn Ile Phe 
                325                 330                 335     

Glu Asp Phe Gln Thr Gly Gly Val Pro Leu Ala Leu Glu Arg Asp Ala 
            340                 345                 350         

Thr Asp Gly Val Gln Ser Val His Val Glu Val Lys His Pro Asp Glu 
        355                 360                 365             

Ile Asn Thr Leu Phe Asp Gly Ala Ile Val Tyr Ala Lys Gly Ser Arg 
    370                 375                 380                 

Leu Met His Met Leu Arg Arg Trp Leu Gly Asp Ala Asp Phe Ala Lys 
385                 390                 395                 400 

Gly Leu His Ala Tyr Phe Glu Lys His Gln Tyr Ser Asn Thr Ile Gly 
                405                 410                 415     

Ser Asp Leu Trp Asp Ala Leu Gly Gln Ala Ser Gly Arg Asp Val Ala 
            420                 425                 430         

Ala Phe Met Asp Ser Trp Leu Glu Gln Pro Gly Tyr Pro Val Leu Thr 
        435                 440                 445             

Val Lys Val Glu Asn Asp Val Leu Lys Ile Ser Gln Lys Gln Phe Phe 
    450                 455                 460                 

Ile Gly Glu Asn Glu Asp Lys Asn Arg Leu Trp Val Val Pro Leu Asn 
465                 470                 475                 480 

Ser Asn Trp Lys Gly Leu Pro Asp Thr Leu Glu Thr Glu Ser Ile Glu 
                485                 490                 495     

Ile Pro Gly Tyr Ala Ala Leu Leu Ala Glu Asn Glu Gly Ala Leu Arg 
            500                 505                 510         

Leu Asn Thr Glu Asn Thr Ala His Tyr Ile Thr Asp Tyr Gln Gly Asp 
        515                 520                 525             

Leu Leu Ala Ala Val Leu Ala Glu Leu Glu Thr Leu Asp Asn Thr Ser 
    530                 535                 540                 

Lys Leu Gln Ile Val Gln Glu Arg Arg Leu Leu Ala Glu Ala Gly His 
545                 550                 555                 560 

Ile Ser Tyr Ala Asp Leu Leu Pro Val Leu Asp Lys Leu Ala Lys Glu 
                565                 570                 575     

Glu Ser Tyr Leu Val Val Ser Ala Val Ser Gln Val Ile Ser Ala Leu 
            580                 585                 590         

Glu Arg Phe Ile Asp Glu Gly Thr Asp Ala Glu Thr Ala Phe Lys Gly 
        595                 600                 605             

Leu Val Ala Lys Leu Ala Arg His Asn Tyr Asp Arg Leu Gly Phe Glu 
    610                 615                 620                 

Ala Lys Asp Gly Glu Ser Asp Glu Asp Glu Leu Val Arg Gln Leu Ala 
625                 630                 635                 640 

Val Ser Met Met Ile Arg Ser Asn Asp Ala Glu Ala Ser Gln Val Ala 
                645                 650                 655     

Ser Gln Ile Phe Ala Thr His Lys Glu Asn Leu Ala Gly Leu Pro Ala 
            660                 665                 670         

Ala Ile Arg Ser Gln Val Leu Ile Asn Glu Met Lys His His Glu Thr 
        675                 680                 685             

Lys Asp Leu Leu Ala Leu Tyr Leu Asp Thr Tyr Thr His Ala Thr Asp 
    690                 695                 700                 

Ala Val Phe Lys Arg Gln Leu Ala Ala Ala Leu Ala Tyr Ser Thr Asp 
705                 710                 715                 720 

Ala Asp Asn Ile Gln Asn Leu Ile Thr Ser Trp Lys Asp Lys Phe Val 
                725                 730                 735     

Val Lys Pro Gln Asp Leu Ser Ala Trp Tyr Tyr Gln Phe Leu Ala His 
            740                 745                 750         

Gln Ala Thr Gln Lys Thr Ala Trp Ser Trp Ala Arg Glu Asn Trp Ala 
        755                 760                 765             

Trp Ile Lys Ala Ala Leu Gly Gly Asp Met Ser Phe Asp Ser Phe Val 
    770                 775                 780                 

Ile Leu Pro Ala His Val Phe Lys Thr Gln Gln Arg Leu Ala Glu Tyr 
785                 790                 795                 800 

Lys Glu Phe Phe Glu Pro Gln Leu Ser Asp Leu Ala Leu Ser Arg Asn 
                805                 810                 815     

Ile Gly Met Gly Ile Lys Glu Ile Ala Ala Arg Val Asp Leu Ile Ser 
            820                 825                 830         

Arg Glu Lys Ala Ala Val Glu Ala Val Val Leu Gln Tyr Gly Asn Ala 
        835                 840                 845             


<210>   1521
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1521
atgcagagag ttgagttttt tttaaggcaa atttggtata atagttttaa taaggaggag   60
tttctcatga taaaaatctt attggttgag gatgacctag gtctgtcaaa ttcagtattt   120
gactttttag acgattttgc ggatgttatg caggtatttg atggagaaga aggtctctac   180
gaagctgaga gtggtgtcta tgacttgatt ttgctggatt tgatgttgcc agaaaaaaat   240
ggtttccaag tcttaaaaga attgcgtgaa aagggaatta cgacaccagt tctgattatg   300
actgccaagg aaagtttgga tgacaaggga catggatttg aactgggagc ggatgattat   360
ctgaccaaac ctttctacct agaagaactt aaaatgcgga ttcaggccct tctcaaacgt   420
tcagggaagt ttaatgaaaa caccttgact tatgggaata tcgtggttaa tttatcaacc   480
aataccgtta aagttgaaga tactcctgtc gaattgctgg ggaaagagtt cgatttacta   540
gtttatttcc ttcaaaatca aaatgtgatt ttgcctaaga cgcagatttt tgaccgtcta   600
tggggatttg atagtgatac aacgatttcg gttgtcgaag tctatgtttc aaaagtccgt   660
aagaaattaa agggaaccac ttttgcagag aatttgcaaa ctttgcgtag tgttgggtat   720
cttttaaaag atgttcag                                                 738

<210>   1522
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator CiaR (ciaR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902751 (e-125)

<400>   1522
Met Gln Arg Val Glu Phe Phe Leu Arg Gln Ile Trp Tyr Asn Ser Phe 
1               5                   10                  15      

Asn Lys Glu Glu Phe Leu Met Ile Lys Ile Leu Leu Val Glu Asp Asp 
            20                  25                  30          

Leu Gly Leu Ser Asn Ser Val Phe Asp Phe Leu Asp Asp Phe Ala Asp 
        35                  40                  45              

Val Met Gln Val Phe Asp Gly Glu Glu Gly Leu Tyr Glu Ala Glu Ser 
    50                  55                  60                  

Gly Val Tyr Asp Leu Ile Leu Leu Asp Leu Met Leu Pro Glu Lys Asn 
65                  70                  75                  80  

Gly Phe Gln Val Leu Lys Glu Leu Arg Glu Lys Gly Ile Thr Thr Pro 
                85                  90                  95      

Val Leu Ile Met Thr Ala Lys Glu Ser Leu Asp Asp Lys Gly His Gly 
            100                 105                 110         

Phe Glu Leu Gly Ala Asp Asp Tyr Leu Thr Lys Pro Phe Tyr Leu Glu 
        115                 120                 125             

Glu Leu Lys Met Arg Ile Gln Ala Leu Leu Lys Arg Ser Gly Lys Phe 
    130                 135                 140                 

Asn Glu Asn Thr Leu Thr Tyr Gly Asn Ile Val Val Asn Leu Ser Thr 
145                 150                 155                 160 

Asn Thr Val Lys Val Glu Asp Thr Pro Val Glu Leu Leu Gly Lys Glu 
                165                 170                 175     

Phe Asp Leu Leu Val Tyr Phe Leu Gln Asn Gln Asn Val Ile Leu Pro 
            180                 185                 190         

Lys Thr Gln Ile Phe Asp Arg Leu Trp Gly Phe Asp Ser Asp Thr Thr 
        195                 200                 205             

Ile Ser Val Val Glu Val Tyr Val Ser Lys Val Arg Lys Lys Leu Lys 
    210                 215                 220                 

Gly Thr Thr Phe Ala Glu Asn Leu Gln Thr Leu Arg Ser Val Gly Tyr 
225                 230                 235                 240 

Leu Leu Lys Asp Val Gln 
                245     

<210>   1523
<211>   1332
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1523
atgttcagta aacttaaaaa aacatggtat gcggatgact ttagttattt tatccgcaac   60
ttcggtgtct tcaccctgat tttttctaca atgactctga ttattttaca agtcatgcat   120
tcgagtcttt atacttcggt ggacgataag cttcatggac tgagtgaaaa tcctcaagca   180
gttattcagc tggctataaa tagggcaaca gaagagatta aagatttaga aaatgctagg   240
gcggacgcta gtaaagtaga aataaaacct aatgtcagtt ccaatacgga agtcattctc   300
tttgataaag actttactca acttctttct ggaaatcgat ttttgggctt ggataagatt   360
aagttagaaa agaaagaact aggacatatc taccagattc aggtttttaa tagctatggg   420
caggaagaaa tctatcgtgt gattttgatg gagaccaata ttagttcggt ttcaaccaat   480
atcaagtatg ctgctgtctt gattaatacc agtcagttgg aacaggctag tcaaaagcat   540
gagcaattga ttgtggtcgt gatggctagt ttctggattt tgtctttact tgccagtctc   600
tatctagcta gggtcagtgt taggcccctg cttgagagta tgcagaagca acagtctttt   660
gtggaaaatg ccagtcatga gttacgaact ccactcgcag ttttgcaaaa tcgcttagag   720
accctttttc gtaagccaga agctaccatt atggatgtga gcgaaagcat tgcatcgagt   780
ttggaagaag tccgaaatat gcgtttttta acgacaagct tgctgaactt agctcggaga   840
gatgatggga ttaagccgga gcttgcagaa gttccaacta gcttttttaa tacaactttc   900
acaaactacg agatgattgc ttcggaaaat aatcgtgtct tccgttttga aaatcgtatc   960
catcgaacaa ttgtcacaga tcagcttctt ctgaaacaac tgatgaccat tcttttcgat   1020
aatgccgtca agtatactga ggaggatggt gaaattgatt ttcttatctc ggcgaccgat   1080
cgcaatcttt atttacttgt ttctgataat ggaatcggta tttcgacaga agataaaaag   1140
aaaatttttg accgttttta tcgagtagac aaggctagaa cccggcaaaa aggtggtttt   1200
ggtttaggat tatccctagc caagcaaatt gtagatgctc taaaaggaac tgttactgtc   1260
aaagataata aacccaaggg aacaatcttt gaagtgaaga ttgccattca gacaccatct   1320
aaaaagaaaa aa                                                       1332

<210>   1524
<211>   444
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase CiaH (ciaH)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902752 (0.E+01)

<400>   1524
Met Phe Ser Lys Leu Lys Lys Thr Trp Tyr Ala Asp Asp Phe Ser Tyr 
1               5                   10                  15      

Phe Ile Arg Asn Phe Gly Val Phe Thr Leu Ile Phe Ser Thr Met Thr 
            20                  25                  30          

Leu Ile Ile Leu Gln Val Met His Ser Ser Leu Tyr Thr Ser Val Asp 
        35                  40                  45              

Asp Lys Leu His Gly Leu Ser Glu Asn Pro Gln Ala Val Ile Gln Leu 
    50                  55                  60                  

Ala Ile Asn Arg Ala Thr Glu Glu Ile Lys Asp Leu Glu Asn Ala Arg 
65                  70                  75                  80  

Ala Asp Ala Ser Lys Val Glu Ile Lys Pro Asn Val Ser Ser Asn Thr 
                85                  90                  95      

Glu Val Ile Leu Phe Asp Lys Asp Phe Thr Gln Leu Leu Ser Gly Asn 
            100                 105                 110         

Arg Phe Leu Gly Leu Asp Lys Ile Lys Leu Glu Lys Lys Glu Leu Gly 
        115                 120                 125             

His Ile Tyr Gln Ile Gln Val Phe Asn Ser Tyr Gly Gln Glu Glu Ile 
    130                 135                 140                 

Tyr Arg Val Ile Leu Met Glu Thr Asn Ile Ser Ser Val Ser Thr Asn 
145                 150                 155                 160 

Ile Lys Tyr Ala Ala Val Leu Ile Asn Thr Ser Gln Leu Glu Gln Ala 
                165                 170                 175     

Ser Gln Lys His Glu Gln Leu Ile Val Val Val Met Ala Ser Phe Trp 
            180                 185                 190         

Ile Leu Ser Leu Leu Ala Ser Leu Tyr Leu Ala Arg Val Ser Val Arg 
        195                 200                 205             

Pro Leu Leu Glu Ser Met Gln Lys Gln Gln Ser Phe Val Glu Asn Ala 
    210                 215                 220                 

Ser His Glu Leu Arg Thr Pro Leu Ala Val Leu Gln Asn Arg Leu Glu 
225                 230                 235                 240 

Thr Leu Phe Arg Lys Pro Glu Ala Thr Ile Met Asp Val Ser Glu Ser 
                245                 250                 255     

Ile Ala Ser Ser Leu Glu Glu Val Arg Asn Met Arg Phe Leu Thr Thr 
            260                 265                 270         

Ser Leu Leu Asn Leu Ala Arg Arg Asp Asp Gly Ile Lys Pro Glu Leu 
        275                 280                 285             

Ala Glu Val Pro Thr Ser Phe Phe Asn Thr Thr Phe Thr Asn Tyr Glu 
    290                 295                 300                 

Met Ile Ala Ser Glu Asn Asn Arg Val Phe Arg Phe Glu Asn Arg Ile 
305                 310                 315                 320 

His Arg Thr Ile Val Thr Asp Gln Leu Leu Leu Lys Gln Leu Met Thr 
                325                 330                 335     

Ile Leu Phe Asp Asn Ala Val Lys Tyr Thr Glu Glu Asp Gly Glu Ile 
            340                 345                 350         

Asp Phe Leu Ile Ser Ala Thr Asp Arg Asn Leu Tyr Leu Leu Val Ser 
        355                 360                 365             

Asp Asn Gly Ile Gly Ile Ser Thr Glu Asp Lys Lys Lys Ile Phe Asp 
    370                 375                 380                 

Arg Phe Tyr Arg Val Asp Lys Ala Arg Thr Arg Gln Lys Gly Gly Phe 
385                 390                 395                 400 

Gly Leu Gly Leu Ser Leu Ala Lys Gln Ile Val Asp Ala Leu Lys Gly 
                405                 410                 415     

Thr Val Thr Val Lys Asp Asn Lys Pro Lys Gly Thr Ile Phe Glu Val 
            420                 425                 430         

Lys Ile Ala Ile Gln Thr Pro Ser Lys Lys Lys Lys 
        435                 440                 

<210>   1525
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1525
atgcccgtaa gaaaattaca atcctatgag gtagactatc aagaagaatt aaaccagcag   60
cttcctcatt accaagctta tacacctgaa gcgcaatctg atgccaatct caaggaaatc   120
ctatttttta ttaatatcgc tgttttttgt atctgtattg ctatctttag ttttatcttt   180
ttagcattaa aattatcaac tgctcttgcc tttgccgcag caatcggatt cagcttactt   240
gttttaaaag ttcaacggtc tattatcaaa cgaaaacgta gaaga                   285

<210>   1526
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902753 (4.E-49)

<400>   1526
Met Pro Val Arg Lys Leu Gln Ser Tyr Glu Val Asp Tyr Gln Glu Glu 
1               5                   10                  15      

Leu Asn Gln Gln Leu Pro His Tyr Gln Ala Tyr Thr Pro Glu Ala Gln 
            20                  25                  30          

Ser Asp Ala Asn Leu Lys Glu Ile Leu Phe Phe Ile Asn Ile Ala Val 
        35                  40                  45              

Phe Cys Ile Cys Ile Ala Ile Phe Ser Phe Ile Phe Leu Ala Leu Lys 
    50                  55                  60                  

Leu Ser Thr Ala Leu Ala Phe Ala Ala Ala Ile Gly Phe Ser Leu Leu 
65                  70                  75                  80  

Val Leu Lys Val Gln Arg Ser Ile Ile Lys Arg Lys Arg Arg Arg 
                85                  90                  95  

<210>   1527
<211>   1068
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1527
atgattctct ccttaacagt acatacctat tttatcattt tttcggcaga gaattattac   60
agaaaggtta caaaaagaat aaagtccctt ttcattttca aagcatggct gattttggag   120
aaatgtggta taatttttct tatggaaaag attgtcatta cagcaactgc tgaaagtatt   180
gaacaagttg aacaactact cgaagctggc gtagaccgta tctatgtcgg tgagaaagat   240
tttggtcttc gtctgccaac gacctttagt tatgaccaat tacgtgaaat cgctaagttg   300
gttcatgatg ctggtaagga attgatcgtt gcggtcaatg ctctcatgca ccaagatatg   360
atggaccgta tcaagccttt cttaaacttc ttggaagaaa tcaagacaga ctatattacg   420
attggggatg caggcgtctt ttacgtagtt aaccgcgatg gttattcatt taagaccatc   480
tacgatgctt caaccatggt aactagcagt cgtcagatta acttctgggg acaaaaggct   540
ggcgcatctg aggctgtttt ggcgcgtgaa attccatcag ctgaactttt caaaatgcca   600
gagattttgg aaattcctgc tgaagttttg gtttacggtg ctagcgtcat ccatcattct   660
aaacgtccac tcttgcaaaa ctactataac tttacacata tcgatgatga aaagacgcat   720
aaacgtgacc tcttcttggc tgagccaagt gatccagaga gccactattc catttttgaa   780
gataatcatg ggacccatat ctttgccaac aatgaccttg atttgatgat caaattaaca   840
gaattggtgg agcatggctt tactcgctgg aaactagaag ggctctacac tcctggtcag   900
aactttgttg agattgcaaa actctttatc caagcgcgta gcttgattca agagggcaac   960
tttagtcatg ctcaagcctt cttgctggat gaagaagttc gtaaacttca ccctaaaaac   1020
cgtttccttg atacaggatt ttatgactac gatcctgaca tggttaga                1068

<210>   1528
<211>   356
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902754 (0.E+01)

<400>   1528
Met Ile Leu Ser Leu Thr Val His Thr Tyr Phe Ile Ile Phe Ser Ala 
1               5                   10                  15      

Glu Asn Tyr Tyr Arg Lys Val Thr Lys Arg Ile Lys Ser Leu Phe Ile 
            20                  25                  30          

Phe Lys Ala Trp Leu Ile Leu Glu Lys Cys Gly Ile Ile Phe Leu Met 
        35                  40                  45              

Glu Lys Ile Val Ile Thr Ala Thr Ala Glu Ser Ile Glu Gln Val Glu 
    50                  55                  60                  

Gln Leu Leu Glu Ala Gly Val Asp Arg Ile Tyr Val Gly Glu Lys Asp 
65                  70                  75                  80  

Phe Gly Leu Arg Leu Pro Thr Thr Phe Ser Tyr Asp Gln Leu Arg Glu 
                85                  90                  95      

Ile Ala Lys Leu Val His Asp Ala Gly Lys Glu Leu Ile Val Ala Val 
            100                 105                 110         

Asn Ala Leu Met His Gln Asp Met Met Asp Arg Ile Lys Pro Phe Leu 
        115                 120                 125             

Asn Phe Leu Glu Glu Ile Lys Thr Asp Tyr Ile Thr Ile Gly Asp Ala 
    130                 135                 140                 

Gly Val Phe Tyr Val Val Asn Arg Asp Gly Tyr Ser Phe Lys Thr Ile 
145                 150                 155                 160 

Tyr Asp Ala Ser Thr Met Val Thr Ser Ser Arg Gln Ile Asn Phe Trp 
                165                 170                 175     

Gly Gln Lys Ala Gly Ala Ser Glu Ala Val Leu Ala Arg Glu Ile Pro 
            180                 185                 190         

Ser Ala Glu Leu Phe Lys Met Pro Glu Ile Leu Glu Ile Pro Ala Glu 
        195                 200                 205             

Val Leu Val Tyr Gly Ala Ser Val Ile His His Ser Lys Arg Pro Leu 
    210                 215                 220                 

Leu Gln Asn Tyr Tyr Asn Phe Thr His Ile Asp Asp Glu Lys Thr His 
225                 230                 235                 240 

Lys Arg Asp Leu Phe Leu Ala Glu Pro Ser Asp Pro Glu Ser His Tyr 
                245                 250                 255     

Ser Ile Phe Glu Asp Asn His Gly Thr His Ile Phe Ala Asn Asn Asp 
            260                 265                 270         

Leu Asp Leu Met Ile Lys Leu Thr Glu Leu Val Glu His Gly Phe Thr 
        275                 280                 285             

Arg Trp Lys Leu Glu Gly Leu Tyr Thr Pro Gly Gln Asn Phe Val Glu 
    290                 295                 300                 

Ile Ala Lys Leu Phe Ile Gln Ala Arg Ser Leu Ile Gln Glu Gly Asn 
305                 310                 315                 320 

Phe Ser His Ala Gln Ala Phe Leu Leu Asp Glu Glu Val Arg Lys Leu 
                325                 330                 335     

His Pro Lys Asn Arg Phe Leu Asp Thr Gly Phe Tyr Asp Tyr Asp Pro 
            340                 345                 350         

Asp Met Val Arg 
        355     

<210>   1529
<211>   2448
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   1529
atgaaaacga ttggtaatcg ctatgttgtg gtggatttag aggcaactag cacaggtagt   60
aaggctaaaa ttatccaagt gggaattgtc gtgattgagg acggagaaat cgtcgatcac   120
tatacgacgg atgtcaatcc acatgaaccc ttggatgctc atatcaaaga actgacagga   180
ttgacagacc aacgtctggc gcaagcacct gatttttcgc aagttgccag aaaaatattt   240
gacttggtgg aggatgggat ttttgtagcc cataatgttc agtttgatgc taatctcttg   300
gcggaaaatt tattttttga aggctatgag ctaagaaacc ctcgtgttga tacggtcgaa   360
ttggcccagg tctttttccc tgaactggaa aaatatagct tgccgatttt gtgtcgagaa   420
ttaggaattc ctcttaaaca cgcacacaca gccctttcag atgcccaagc tacagcagaa   480
ttacttcttt ttttacggaa aaagatgacc cagcttccta aaggtctctt ggaacgcttg   540
ctggaaatgg ctgacgctct cctatatgag tcctacctgg ttattgagga aacttatcgc   600
aaccaatcta tcctgagttc tccagacttg gtccaagttc aaggtctata ttttaagaaa   660
acggaagctt ctctggagcc acgaaaacta tctcaagact tttctaaaaa tatttctctg   720
ttgaaccttg aagtgaggga ggaacaagaa agttttgcta aagaggttgg cttgctattg   780
aaagatgaac ctgtctctct gattcaagcg ccgacaggga ttgggaaaac ctatggctat   840
ctcttacccg ctttatctca atccaaagag cgacaaattg ttcttagtgt tccgacaaag   900
attcttcaaa atcaaatcat ggaagaagaa ggtaaacgcc tcaaggaagt gttccataca   960
gatattcata gcttaaaggg accacaaaat tatctgaagt tggatgcctt ttatcattcc   1020
ttgcaggaaa atgatgaaaa tcgcttattt agacgcttta aaatgcaagt cttggtctgg   1080
cttactgaga cagagacagg agatttggat gaaatcgggc aactctaccg ttaccaacat   1140
tttctagcag accttcgtca tgatgggaat ttatcatccc agagcttatt tgtgacggaa   1200
gatttttgga aacgtagtca agaaagggca gagacttgca agcttttagt gactaatcat   1260
gcctatctcg taaccagact tgaagataat cctgaatttg tcagtgaccg tttactgatt   1320
attgatgaag tccaaaagat tttgttagct ctagaaaatc tgcttcaaga gacctacgat   1380
atacaatcta ttatcgattt aattgataag gctttagtag gagaagaaaa cagggttcaa   1440
caacggatac tagaaagtat tcgctttgag tgtctctact tgatagaaca atttcagtct   1500
ggcaaatcta ggaaaaatat cttagattct ctggacaatc tccatcagta tttttcagaa   1560
ttggaagtag aagactttga tgagctggtt cgctatttta cagctgaagg tgattactgg   1620
cttgaagtaa ctgaaacgag tcaaaagaaa attcagattt cttctacaaa atcaggccgt   1680
actcttctgt cctctttact tcctgagagt tgccaagtct tgggagtatc ggctactctt   1740
gagattagtc agagggtttc tttggcagac cttttaggct atcctgaagc taaatttgtc   1800
aagattgaat ctcggggaaa acaggaacaa gaagtggtca tggtcaaaga tttccctctg   1860
gtaacagaaa cctccttaga agtctatgcc agagaggtag ctgctttact agtggaaatt   1920
caagctttcc agcaaccgat tttggttctc tttaccgcta aagacatgct tctagcagta   1980
tcggatttac ttacagttag ccacttggcc cagtataaaa atggggatgt tcatcagcta   2040
aagaaacgct ttgaaaaagg tgaacaacaa atcttgcttg gtgcagcaag tttctgggag   2100
ggagttgatt tttcaagcca tccttctgtg attcaagttg taccgaggct tcctttccaa   2160
aatcctcaag aacccttgac gaaaaagatt aatcaagaac tgaatcaaga agggaaaaat   2220
gccttttatg attatcaatt gccaatggcc attattcgtt taaaacaggc tttgggaaga   2280
agtatgagac gtgaatacca acgttcctta actcttattt tggataggag aatcgtcgga   2340
aaacgatacg gcaaacaaat agtagcatct ctagcagaag aagcgactgt taaaaccatc   2400
tctcgatccg aagttgacga ggctattgat agatttttta atgagctt                2448

<210>   1530
<211>   816
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA polymerase III, epsilon subunit/ATP-dependent helicase DinG
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902755 (0.E+01)

<400>   1530
Met Lys Thr Ile Gly Asn Arg Tyr Val Val Val Asp Leu Glu Ala Thr 
1               5                   10                  15      

Ser Thr Gly Ser Lys Ala Lys Ile Ile Gln Val Gly Ile Val Val Ile 
            20                  25                  30          

Glu Asp Gly Glu Ile Val Asp His Tyr Thr Thr Asp Val Asn Pro His 
        35                  40                  45              

Glu Pro Leu Asp Ala His Ile Lys Glu Leu Thr Gly Leu Thr Asp Gln 
    50                  55                  60                  

Arg Leu Ala Gln Ala Pro Asp Phe Ser Gln Val Ala Arg Lys Ile Phe 
65                  70                  75                  80  

Asp Leu Val Glu Asp Gly Ile Phe Val Ala His Asn Val Gln Phe Asp 
                85                  90                  95      

Ala Asn Leu Leu Ala Glu Asn Leu Phe Phe Glu Gly Tyr Glu Leu Arg 
            100                 105                 110         

Asn Pro Arg Val Asp Thr Val Glu Leu Ala Gln Val Phe Phe Pro Glu 
        115                 120                 125             

Leu Glu Lys Tyr Ser Leu Pro Ile Leu Cys Arg Glu Leu Gly Ile Pro 
    130                 135                 140                 

Leu Lys His Ala His Thr Ala Leu Ser Asp Ala Gln Ala Thr Ala Glu 
145                 150                 155                 160 

Leu Leu Leu Phe Leu Arg Lys Lys Met Thr Gln Leu Pro Lys Gly Leu 
                165                 170                 175     

Leu Glu Arg Leu Leu Glu Met Ala Asp Ala Leu Leu Tyr Glu Ser Tyr 
            180                 185                 190         

Leu Val Ile Glu Glu Thr Tyr Arg Asn Gln Ser Ile Leu Ser Ser Pro 
        195                 200                 205             

Asp Leu Val Gln Val Gln Gly Leu Tyr Phe Lys Lys Thr Glu Ala Ser 
    210                 215                 220                 

Leu Glu Pro Arg Lys Leu Ser Gln Asp Phe Ser Lys Asn Ile Ser Leu 
225                 230                 235                 240 

Leu Asn Leu Glu Val Arg Glu Glu Gln Glu Ser Phe Ala Lys Glu Val 
                245                 250                 255     

Gly Leu Leu Leu Lys Asp Glu Pro Val Ser Leu Ile Gln Ala Pro Thr 
            260                 265                 270         

Gly Ile Gly Lys Thr Tyr Gly Tyr Leu Leu Pro Ala Leu Ser Gln Ser 
        275                 280                 285             

Lys Glu Arg Gln Ile Val Leu Ser Val Pro Thr Lys Ile Leu Gln Asn 
    290                 295                 300                 

Gln Ile Met Glu Glu Glu Gly Lys Arg Leu Lys Glu Val Phe His Thr 
305                 310                 315                 320 

Asp Ile His Ser Leu Lys Gly Pro Gln Asn Tyr Leu Lys Leu Asp Ala 
                325                 330                 335     

Phe Tyr His Ser Leu Gln Glu Asn Asp Glu Asn Arg Leu Phe Arg Arg 
            340                 345                 350         

Phe Lys Met Gln Val Leu Val Trp Leu Thr Glu Thr Glu Thr Gly Asp 
        355                 360                 365             

Leu Asp Glu Ile Gly Gln Leu Tyr Arg Tyr Gln His Phe Leu Ala Asp 
    370                 375                 380                 

Leu Arg His Asp Gly Asn Leu Ser Ser Gln Ser Leu Phe Val Thr Glu 
385                 390                 395                 400 

Asp Phe Trp Lys Arg Ser Gln Glu Arg Ala Glu Thr Cys Lys Leu Leu 
                405                 410                 415     

Val Thr Asn His Ala Tyr Leu Val Thr Arg Leu Glu Asp Asn Pro Glu 
            420                 425                 430         

Phe Val Ser Asp Arg Leu Leu Ile Ile Asp Glu Val Gln Lys Ile Leu 
        435                 440                 445             

Leu Ala Leu Glu Asn Leu Leu Gln Glu Thr Tyr Asp Ile Gln Ser Ile 
    450                 455                 460                 

Ile Asp Leu Ile Asp Lys Ala Leu Val Gly Glu Glu Asn Arg Val Gln 
465                 470                 475                 480 

Gln Arg Ile Leu Glu Ser Ile Arg Phe Glu Cys Leu Tyr Leu Ile Glu 
                485                 490                 495     

Gln Phe Gln Ser Gly Lys Ser Arg Lys Asn Ile Leu Asp Ser Leu Asp 
            500                 505                 510         

Asn Leu His Gln Tyr Phe Ser Glu Leu Glu Val Glu Asp Phe Asp Glu 
        515                 520                 525             

Leu Val Arg Tyr Phe Thr Ala Glu Gly Asp Tyr Trp Leu Glu Val Thr 
    530                 535                 540                 

Glu Thr Ser Gln Lys Lys Ile Gln Ile Ser Ser Thr Lys Ser Gly Arg 
545                 550                 555                 560 

Thr Leu Leu Ser Ser Leu Leu Pro Glu Ser Cys Gln Val Leu Gly Val 
                565                 570                 575     

Ser Ala Thr Leu Glu Ile Ser Gln Arg Val Ser Leu Ala Asp Leu Leu 
            580                 585                 590         

Gly Tyr Pro Glu Ala Lys Phe Val Lys Ile Glu Ser Arg Gly Lys Gln 
        595                 600                 605             

Glu Gln Glu Val Val Met Val Lys Asp Phe Pro Leu Val Thr Glu Thr 
    610                 615                 620                 

Ser Leu Glu Val Tyr Ala Arg Glu Val Ala Ala Leu Leu Val Glu Ile 
625                 630                 635                 640 

Gln Ala Phe Gln Gln Pro Ile Leu Val Leu Phe Thr Ala Lys Asp Met 
                645                 650                 655     

Leu Leu Ala Val Ser Asp Leu Leu Thr Val Ser His Leu Ala Gln Tyr 
            660                 665                 670         

Lys Asn Gly Asp Val His Gln Leu Lys Lys Arg Phe Glu Lys Gly Glu 
        675                 680                 685             

Gln Gln Ile Leu Leu Gly Ala Ala Ser Phe Trp Glu Gly Val Asp Phe 
    690                 695                 700                 

Ser Ser His Pro Ser Val Ile Gln Val Val Pro Arg Leu Pro Phe Gln 
705                 710                 715                 720 

Asn Pro Gln Glu Pro Leu Thr Lys Lys Ile Asn Gln Glu Leu Asn Gln 
                725                 730                 735     

Glu Gly Lys Asn Ala Phe Tyr Asp Tyr Gln Leu Pro Met Ala Ile Ile 
            740                 745                 750         

Arg Leu Lys Gln Ala Leu Gly Arg Ser Met Arg Arg Glu Tyr Gln Arg 
        755                 760                 765             

Ser Leu Thr Leu Ile Leu Asp Arg Arg Ile Val Gly Lys Arg Tyr Gly 
    770                 775                 780                 

Lys Gln Ile Val Ala Ser Leu Ala Glu Glu Ala Thr Val Lys Thr Ile 
785                 790                 795                 800 

Ser Arg Ser Glu Val Asp Glu Ala Ile Asp Arg Phe Phe Asn Glu Leu 
                805                 810                 815     


<210>   1531
<211>   1248
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1531
ttgtatgaaa gtataaggtt agtatatatg aaacgttctc tcgactcaag agtcgattac   60

agtttgctct tgccagtatt ttttctactg gtcatcggtg tggtggctat ctatatagcc   120
gttagtcatg attatcccaa taatattctg cccattttag ggcagcaggt cgcctggatt   180
gccttggggc ttgtgattgg ttttgtggtc atgctcttta atacagaatt tctttggaag   240
gtgaccccct ttctatatat tttaggcttg ggacttatga tcttgccgat tgtattttat   300
aatccaagct tagttgcatc aacgggtgcc aaaaactggg tatcaataaa tggaattacc   360
ctattccaac cgtcagaatt tatgaagata tcctatatcc tcatgttggc tcgtgtcatt   420
gtccaattta caaagaaaca taaggaatgg agacgcacgg ttccgctgga ctttttgtta   480
attttctgga tgattctctt taccattcca gtcctagttc ttttagcact tcaaagtgac   540
ttggggacgg ctttggtttt tgtagccatt ttctcaggaa tcgttttatt atcaggggtt   600
tcttggaaaa ttattatccc agtatttgtg actgctgtaa caggagttgc tggtttctta   660
gctatcttta ttagcaagga cggacgagct tttcttcacc agattggaat gccgacctac   720
caaattaatc ggattttggc ttggctcaat ccctttgagt ttgcccaaac aacgacttac   780
cagcaggctc aagggcagat tgccattggg agtggtggct tatttggtca gggatttaat   840
gcttcgaatc tgcttatccc agttcgagag tcagatatga tttttacggt tattgcagaa   900
gattttggct ttattggctc tgtcctggtt attgccctct atctcatgtt gatttaccgt   960
atgttgaaga ttactcttaa atcaaataac cagttctaca cttatatttc cacaggtttg   1020
attatgatgt tgctcttcca catctttgag aatatcggtg ctgtgactgg actacttcct   1080
ttgacgggga ttcccttgcc tttcatttcg caagggggat cagctattat cagtaatctg   1140
attggtgttg gtttgctttt atcgatgagt taccagacta atctagctga agaaaagagc   1200
ggaaaagtcc cattcaaacg gaaaaaggtt gtattaaaac aaattaaa                1248

<210>   1532
<211>   416
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   rod shape-determining protein RodA, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902756 (0.E+01)

<400>   1532
Met Tyr Glu Ser Ile Arg Leu Val Tyr Met Lys Arg Ser Leu Asp Ser 
1               5                   10                  15      

Arg Val Asp Tyr Ser Leu Leu Leu Pro Val Phe Phe Leu Leu Val Ile 
            20                  25                  30          

Gly Val Val Ala Ile Tyr Ile Ala Val Ser His Asp Tyr Pro Asn Asn 
        35                  40                  45              

Ile Leu Pro Ile Leu Gly Gln Gln Val Ala Trp Ile Ala Leu Gly Leu 
    50                  55                  60                  

Val Ile Gly Phe Val Val Met Leu Phe Asn Thr Glu Phe Leu Trp Lys 
65                  70                  75                  80  

Val Thr Pro Phe Leu Tyr Ile Leu Gly Leu Gly Leu Met Ile Leu Pro 
                85                  90                  95      

Ile Val Phe Tyr Asn Pro Ser Leu Val Ala Ser Thr Gly Ala Lys Asn 
            100                 105                 110         

Trp Val Ser Ile Asn Gly Ile Thr Leu Phe Gln Pro Ser Glu Phe Met 
        115                 120                 125             

Lys Ile Ser Tyr Ile Leu Met Leu Ala Arg Val Ile Val Gln Phe Thr 
    130                 135                 140                 

Lys Lys His Lys Glu Trp Arg Arg Thr Val Pro Leu Asp Phe Leu Leu 
145                 150                 155                 160 

Ile Phe Trp Met Ile Leu Phe Thr Ile Pro Val Leu Val Leu Leu Ala 
                165                 170                 175     

Leu Gln Ser Asp Leu Gly Thr Ala Leu Val Phe Val Ala Ile Phe Ser 
            180                 185                 190         

Gly Ile Val Leu Leu Ser Gly Val Ser Trp Lys Ile Ile Ile Pro Val 
        195                 200                 205             

Phe Val Thr Ala Val Thr Gly Val Ala Gly Phe Leu Ala Ile Phe Ile 
    210                 215                 220                 

Ser Lys Asp Gly Arg Ala Phe Leu His Gln Ile Gly Met Pro Thr Tyr 
225                 230                 235                 240 

Gln Ile Asn Arg Ile Leu Ala Trp Leu Asn Pro Phe Glu Phe Ala Gln 
                245                 250                 255     

Thr Thr Thr Tyr Gln Gln Ala Gln Gly Gln Ile Ala Ile Gly Ser Gly 
            260                 265                 270         

Gly Leu Phe Gly Gln Gly Phe Asn Ala Ser Asn Leu Leu Ile Pro Val 
        275                 280                 285             

Arg Glu Ser Asp Met Ile Phe Thr Val Ile Ala Glu Asp Phe Gly Phe 
    290                 295                 300                 

Ile Gly Ser Val Leu Val Ile Ala Leu Tyr Leu Met Leu Ile Tyr Arg 
305                 310                 315                 320 

Met Leu Lys Ile Thr Leu Lys Ser Asn Asn Gln Phe Tyr Thr Tyr Ile 
                325                 330                 335     

Ser Thr Gly Leu Ile Met Met Leu Leu Phe His Ile Phe Glu Asn Ile 
            340                 345                 350         

Gly Ala Val Thr Gly Leu Leu Pro Leu Thr Gly Ile Pro Leu Pro Phe 
        355                 360                 365             

Ile Ser Gln Gly Gly Ser Ala Ile Ile Ser Asn Leu Ile Gly Val Gly 
    370                 375                 380                 

Leu Leu Leu Ser Met Ser Tyr Gln Thr Asn Leu Ala Glu Glu Lys Ser 
385                 390                 395                 400 

Gly Lys Val Pro Phe Lys Arg Lys Lys Val Val Leu Lys Gln Ile Lys 
                405                 410                 415     


<210>   1533

<211>   552
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1533
atggtaaaag tagcagttat attagctcag ggctttgaag aaattgaagc cttgacagtt   60
gtagatgtct tgcgtcgagc caatatcaca tgtgatatgg ttggttttga agagcaagta   120
acgggttcgc atgcaatcca agtaagagca gatcatgtct ttgatggaga tttatcagac   180
tatgatatga ttgttcttcc tggaggtatg cctggttctg cacatttacg tgataatcag   240
accttgattc aagaattgca aagcttcgag caagaaggga agaaactagc agccatttgt   300
gcggcaccaa ttgccctcaa tcaagcagag atattgaaaa ataagcgata cacttgttat   360
gacggcgttc aagagcaaat ccttgatggt cactacgtca aggaaacagt agtggtagat   420
ggtcagttga caaccagtcg gggtccttca acagcccttg cctttgccta cgagttggtg   480
gagcaactag gaggggacgc agagagttta cgaacaggaa tgctctatcg agatgtcttt   540
ggtaaaaatc ag                                                       552

<210>   1534
<211>   184
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein,
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902757 (e-102)

<400>   1534
Met Val Lys Val Ala Val Ile Leu Ala Gln Gly Phe Glu Glu Ile Glu 
1               5                   10                  15      

Ala Leu Thr Val Val Asp Val Leu Arg Arg Ala Asn Ile Thr Cys Asp 
            20                  25                  30          

Met Val Gly Phe Glu Glu Gln Val Thr Gly Ser His Ala Ile Gln Val 
        35                  40                  45              

Arg Ala Asp His Val Phe Asp Gly Asp Leu Ser Asp Tyr Asp Met Ile 
    50                  55                  60                  

Val Leu Pro Gly Gly Met Pro Gly Ser Ala His Leu Arg Asp Asn Gln 
65                  70                  75                  80  

Thr Leu Ile Gln Glu Leu Gln Ser Phe Glu Gln Glu Gly Lys Lys Leu 
                85                  90                  95      

Ala Ala Ile Cys Ala Ala Pro Ile Ala Leu Asn Gln Ala Glu Ile Leu 
            100                 105                 110         

Lys Asn Lys Arg Tyr Thr Cys Tyr Asp Gly Val Gln Glu Gln Ile Leu 
        115                 120                 125             

Asp Gly His Tyr Val Lys Glu Thr Val Val Val Asp Gly Gln Leu Thr 
    130                 135                 140                 

Thr Ser Arg Gly Pro Ser Thr Ala Leu Ala Phe Ala Tyr Glu Leu Val 
145                 150                 155                 160 

Glu Gln Leu Gly Gly Asp Ala Glu Ser Leu Arg Thr Gly Met Leu Tyr 
                165                 170                 175     

Arg Asp Val Phe Gly Lys Asn Gln 
            180                 

<210>   1535
<211>   570
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1535
atgaagggta tgaaatatca cgattacatc tgggatttag gtggaacttt actggataat   60
tatgaaactt caacagctgc atttgttgaa acattggcac tgtatggtat cacacaagac   120
catgacagtg tctatcaagc tttaaaggtt tctactcctt ttgcgattga gacattcgct   180
cccaatttag agaatttttt agaaaagtac aaggaaaatg aagccagaga gcttgaacac   240
ccgattttat ttgaaggagt ttctgaccta ttggaagaca tttcaaatca aggtggccgt   300
cattttttgg tctctcatcg aaatgatcag gttttggaaa ttttagaaaa aacctctata   360
gcagcttatt ttacagaagt ggtgacttct agctcaggct ttaagagaaa gccaaatccc   420
gaatccatgc tttatttaag agaaaagtat cagattagct ctggtcttgt cattggtgat   480
cggccgattg atatcgaagc aggtcaagct gcaggacttg atacccactt gtttaccagt   540
atcgtgaatt taagacaagt attagacata                                    570

<210>   1536
<211>   190
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydrolase, haloacid dehalogenase-like family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902758 (e-106)

<400>   1536
Met Lys Gly Met Lys Tyr His Asp Tyr Ile Trp Asp Leu Gly Gly Thr 
1               5                   10                  15      

Leu Leu Asp Asn Tyr Glu Thr Ser Thr Ala Ala Phe Val Glu Thr Leu 
            20                  25                  30          

Ala Leu Tyr Gly Ile Thr Gln Asp His Asp Ser Val Tyr Gln Ala Leu 
        35                  40                  45              

Lys Val Ser Thr Pro Phe Ala Ile Glu Thr Phe Ala Pro Asn Leu Glu 
    50                  55                  60                  

Asn Phe Leu Glu Lys Tyr Lys Glu Asn Glu Ala Arg Glu Leu Glu His 
65                  70                  75                  80  

Pro Ile Leu Phe Glu Gly Val Ser Asp Leu Leu Glu Asp Ile Ser Asn 
                85                  90                  95      

Gln Gly Gly Arg His Phe Leu Val Ser His Arg Asn Asp Gln Val Leu 
            100                 105                 110         

Glu Ile Leu Glu Lys Thr Ser Ile Ala Ala Tyr Phe Thr Glu Val Val 
        115                 120                 125             

Thr Ser Ser Ser Gly Phe Lys Arg Lys Pro Asn Pro Glu Ser Met Leu 
    130                 135                 140                 

Tyr Leu Arg Glu Lys Tyr Gln Ile Ser Ser Gly Leu Val Ile Gly Asp 
145                 150                 155                 160 

Arg Pro Ile Asp Ile Glu Ala Gly Gln Ala Ala Gly Leu Asp Thr His 
                165                 170                 175     

Leu Phe Thr Ser Ile Val Asn Leu Arg Gln Val Leu Asp Ile 
            180                 185                 190 

<210>   1537
<211>   1944
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1537
atgacagaag aaatcaaaaa tctgcaggca caggattatg atgccagtca aattcaagtt   60
ttagagggct tagaggctgt tcgtatgcgt ccagggatgt acattggatc aacctcaaaa   120
gaaggtcttc accatctagt ctgggaaatt gttgataact caattgacga ggccttggca   180
ggatttgcca gccatattca agtttttatt gagccagatg attcgattac tgttgtggat   240
gatgggcgtg gtatcccagt cgatattcag gaaaaaacag gccgtcctgc tgttgagacc   300
gtctttacag tccttcacgc tggaggaaag ttcggcggtg gtggatacaa ggtttcaggt   360
ggtcttcacg gggtggggtc gtcagtagtt aatgcccttt ccactcaatt agacgttcat   420
gttcacaaaa atggtaagat tcattaccaa gaataccgtc gtggtcatgt tgtcgcagat   480
cttgaaatag ttggagatac ggataaaaca ggaacaactg ttcacttcac accggaccca   540
aaaatcttca ctgaaacaac aatctttgat tttgataaat taaataaacg gattcaagag   600
ttggcctttc taaatcgcgg tcttcaaatt tcaattacag ataagcgcca aggtttggaa   660
caaaccaagc attatcatta tgaaggtggg attgctagtt acgttgaata tatcaacgag   720
aacaaggatg taatctttga tacaccaatc tatacagacg gtgagatgga tgatatcaca   780
gttgaggtag ccatgcagta cacaactggt taccatgaaa atgtcatgag tttcgccaat   840
aatattcata cccatgaagg tggaacacat gaacaaggtt tccgtacagc cttgacacgt   900
gttatcaacg attatgctcg taaaaataag ttactgaaag acaatgaaga taatttaaca   960
ggggaagatg ttcgcgaagg cttaactgca gttatctcag ttaaacaccc aaatccacag   1020
tttgaaggac aaaccaagac caaattggga aatagcgaag tggtcaagat taccaatcgc   1080
ctcttcagtg aagctttctc cgatttcctc atggaaaatc cacagattgc caaacgtatc   1140
gtagaaaaag gaattttggc tgccaaggct cgtgtggctg ccaagcgtgc gcgtgaagtc   1200
acacgtaaaa aatctggttt ggaaatttcc aaccttccag ggaaactagc agactgttct   1260
tctaataacc ctgctgaaac agaactcttc atcgtcgaag gagactcagc tggtggatca   1320
gccaaatctg gtcgtaaccg tgagtttcag gctatccttc caattcgcgg taagattttg   1380
aacgttgaaa aagcaagtat ggataagatt ctagccaacg aagaaattcg tagtcttttc   1440
acagccatgg gaacaggatt tggcgcagaa tttgatgttt cgaaagcccg ttaccaaaaa   1500
ctcgttttga tgaccgatgc cgatgtcgat ggagcccaca ttcgtaccct tcttttaacc   1560
ttgatttatc gttatatgaa accaatccta gaagctggtt atgtttatat tgcccaacca   1620
ccaatctatg gtgtcaaggt tggaagcgag attaaagaat atatccagcc gggtgcagat   1680
caagaaatca aactccaaga agctttagcc cgttatagtg aaggtcgtac caaaccgact   1740
attcagcgtt ataaggggct aggtgaaatg gacgatcatc agctgtggga aacaaccatg   1800
gatcccgaac atcgcttgat ggctagagtt tctgtagatg atgctgcaga agcagataaa   1860
atctttgata tgttgatggg ggatcgagta gagcctcgtc gtgagtttat cgaagaaaat   1920
gctgtctata gtacacttga tgtc                                          1944

<210>   1538
<211>   648
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA gyrase subunit B (gyrB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902759 (0.E+01)

<400>   1538
Met Thr Glu Glu Ile Lys Asn Leu Gln Ala Gln Asp Tyr Asp Ala Ser 
1               5                   10                  15      

Gln Ile Gln Val Leu Glu Gly Leu Glu Ala Val Arg Met Arg Pro Gly 
            20                  25                  30          

Met Tyr Ile Gly Ser Thr Ser Lys Glu Gly Leu His His Leu Val Trp 
        35                  40                  45              

Glu Ile Val Asp Asn Ser Ile Asp Glu Ala Leu Ala Gly Phe Ala Ser 
    50                  55                  60                  

His Ile Gln Val Phe Ile Glu Pro Asp Asp Ser Ile Thr Val Val Asp 
65                  70                  75                  80  

Asp Gly Arg Gly Ile Pro Val Asp Ile Gln Glu Lys Thr Gly Arg Pro 
                85                  90                  95      

Ala Val Glu Thr Val Phe Thr Val Leu His Ala Gly Gly Lys Phe Gly 
            100                 105                 110         

Gly Gly Gly Tyr Lys Val Ser Gly Gly Leu His Gly Val Gly Ser Ser 
        115                 120                 125             

Val Val Asn Ala Leu Ser Thr Gln Leu Asp Val His Val His Lys Asn 
    130                 135                 140                 

Gly Lys Ile His Tyr Gln Glu Tyr Arg Arg Gly His Val Val Ala Asp 
145                 150                 155                 160 

Leu Glu Ile Val Gly Asp Thr Asp Lys Thr Gly Thr Thr Val His Phe 
                165                 170                 175     

Thr Pro Asp Pro Lys Ile Phe Thr Glu Thr Thr Ile Phe Asp Phe Asp 
            180                 185                 190         

Lys Leu Asn Lys Arg Ile Gln Glu Leu Ala Phe Leu Asn Arg Gly Leu 
        195                 200                 205             

Gln Ile Ser Ile Thr Asp Lys Arg Gln Gly Leu Glu Gln Thr Lys His 
    210                 215                 220                 

Tyr His Tyr Glu Gly Gly Ile Ala Ser Tyr Val Glu Tyr Ile Asn Glu 
225                 230                 235                 240 

Asn Lys Asp Val Ile Phe Asp Thr Pro Ile Tyr Thr Asp Gly Glu Met 
                245                 250                 255     

Asp Asp Ile Thr Val Glu Val Ala Met Gln Tyr Thr Thr Gly Tyr His 
            260                 265                 270         

Glu Asn Val Met Ser Phe Ala Asn Asn Ile His Thr His Glu Gly Gly 
        275                 280                 285             

Thr His Glu Gln Gly Phe Arg Thr Ala Leu Thr Arg Val Ile Asn Asp 
    290                 295                 300                 

Tyr Ala Arg Lys Asn Lys Leu Leu Lys Asp Asn Glu Asp Asn Leu Thr 
305                 310                 315                 320 

Gly Glu Asp Val Arg Glu Gly Leu Thr Ala Val Ile Ser Val Lys His 
                325                 330                 335     

Pro Asn Pro Gln Phe Glu Gly Gln Thr Lys Thr Lys Leu Gly Asn Ser 
            340                 345                 350         

Glu Val Val Lys Ile Thr Asn Arg Leu Phe Ser Glu Ala Phe Ser Asp 
        355                 360                 365             

Phe Leu Met Glu Asn Pro Gln Ile Ala Lys Arg Ile Val Glu Lys Gly 
    370                 375                 380                 

Ile Leu Ala Ala Lys Ala Arg Val Ala Ala Lys Arg Ala Arg Glu Val 
385                 390                 395                 400 

Thr Arg Lys Lys Ser Gly Leu Glu Ile Ser Asn Leu Pro Gly Lys Leu 
                405                 410                 415     

Ala Asp Cys Ser Ser Asn Asn Pro Ala Glu Thr Glu Leu Phe Ile Val 
            420                 425                 430         

Glu Gly Asp Ser Ala Gly Gly Ser Ala Lys Ser Gly Arg Asn Arg Glu 
        435                 440                 445             

Phe Gln Ala Ile Leu Pro Ile Arg Gly Lys Ile Leu Asn Val Glu Lys 
    450                 455                 460                 

Ala Ser Met Asp Lys Ile Leu Ala Asn Glu Glu Ile Arg Ser Leu Phe 
465                 470                 475                 480 

Thr Ala Met Gly Thr Gly Phe Gly Ala Glu Phe Asp Val Ser Lys Ala 
                485                 490                 495     

Arg Tyr Gln Lys Leu Val Leu Met Thr Asp Ala Asp Val Asp Gly Ala 
            500                 505                 510         

His Ile Arg Thr Leu Leu Leu Thr Leu Ile Tyr Arg Tyr Met Lys Pro 
        515                 520                 525             

Ile Leu Glu Ala Gly Tyr Val Tyr Ile Ala Gln Pro Pro Ile Tyr Gly 
    530                 535                 540                 

Val Lys Val Gly Ser Glu Ile Lys Glu Tyr Ile Gln Pro Gly Ala Asp 
545                 550                 555                 560 

Gln Glu Ile Lys Leu Gln Glu Ala Leu Ala Arg Tyr Ser Glu Gly Arg 
                565                 570                 575     

Thr Lys Pro Thr Ile Gln Arg Tyr Lys Gly Leu Gly Glu Met Asp Asp 
            580                 585                 590         

His Gln Leu Trp Glu Thr Thr Met Asp Pro Glu His Arg Leu Met Ala 
        595                 600                 605             

Arg Val Ser Val Asp Asp Ala Ala Glu Ala Asp Lys Ile Phe Asp Met 
    610                 615                 620                 

Leu Met Gly Asp Arg Val Glu Pro Arg Arg Glu Phe Ile Glu Glu Asn 
625                 630                 635                 640 

Ala Val Tyr Ser Thr Leu Asp Val 
                645             

<210>   1539
<211>   1725
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1539
atgtctaatg gacaactaat ttatttaatg gttgcaattg cagtcatttt agttctggct   60
tatgtagtgg caatctttct acgtaagcga aacgagggga gattagaggc gctagaagaa   120
aaaaaagaag aactatacaa tcttccagta aatgatgaag tagaagctgt aaaaaatatg   180
cacttgattg gacaaagtca agtggctttc cgtgaatgga atcaaaaatg ggtcgattta   240
tctctcaact cttttgccga tattgaaaat aatctctttg aagcagaagg ctataaccat   300
tcatttcgtt ttctcaaggc cagtcatcaa attgaccaaa ttgagagtca aattactttg   360
attgaagaag atattgcggc aattcgcaat gctttggcag acttagagaa gcaagaatct   420
aaaaatagtg gtcgtgttct tcatgctttg gatttatttg aggaacttca gcatagagtt   480
gctgaaaatt cagaacagta tggtcaagcc ttggatgaaa ttgaaaaaca attagaaaat   540
atccaatctg aattttcaca atttgtaacc ttgaattcat cgggtgaccc tgtggaagcc   600
gcagtgattt tggataatac agaaaatcac attttggcct taagtcatat tgtggatcgt   660
gttccagcct tggttacgac gctttctaca gaattgccag atcaattaca ggatttggaa   720
gccggttatc gtaaactaat tgatgctaat tatcattttg ttgaaacgga tattgaagcg   780
cgtttccact tgctttatga agcattcaag aaaaaccaag agaatattcg tcagttggaa   840
ttggataatg ccgaatatga gaatggacag gcacaagagg aaatcaatgc cttgtatgat   900
atttttactc gagaaattgc tgctcagaaa gtagtggaaa atctacttgc aactcttcca   960
acttatcttc aacatatgaa agagaataat actttattgg gagaagatat tgcacgtttg   1020
aacaagacct atttacttcc tgagacagct gcaagccatg ttcgtcgtat tcagacagaa   1080
ttagagagtt ttgaggcagc tattgttgag gtaacttcaa atcaagaaga accaacccaa   1140
gcttattcag ttcttgaaga aaatcttgag gatttacaaa ctcaactaaa agatattgaa   1200
gatgagcaaa tttcagttag tgagcgcctg acacaaattg agaaagatga tattaatgca   1260
cgtcaaaagg ccaatgttta tgtcaatcgt ctccatacta tcaagcgata catggaaaaa   1320
cgcaatctgc caggtattcc acaaactttc ttgaagttat tctttacggc aagcaataat   1380
accgaggatt taatggttga gttagaacaa aaaatgatta acattgaatc tgttacccga   1440
gttcttgaaa ttgcaacgaa tgatatggaa gctttagaaa cggaaactta taatattgta   1500
caatatgcaa ctttgacaga gcaactcttg caatattcta accgctatcg ctcatttgat   1560
gaacgcattc aagaagcatt taacgaagct ttagatattt ttgaaaaaga atttgattat   1620
cacgcttcat ttgacaagat ttctcaagca ttggaagtgg cagagcctgg tgtaaccaat   1680
cgctttgtta cctcatatga gaaaacacgt gaaacgattc gtttt                   1725

<210>   1540
<211>   575
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   septation ring formation regulator EzrA, putative
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902760 (0.E+01)

<400>   1540
Met Ser Asn Gly Gln Leu Ile Tyr Leu Met Val Ala Ile Ala Val Ile 
1               5                   10                  15      

Leu Val Leu Ala Tyr Val Val Ala Ile Phe Leu Arg Lys Arg Asn Glu 
            20                  25                  30          

Gly Arg Leu Glu Ala Leu Glu Glu Lys Lys Glu Glu Leu Tyr Asn Leu 
        35                  40                  45              

Pro Val Asn Asp Glu Val Glu Ala Val Lys Asn Met His Leu Ile Gly 
    50                  55                  60                  

Gln Ser Gln Val Ala Phe Arg Glu Trp Asn Gln Lys Trp Val Asp Leu 
65                  70                  75                  80  

Ser Leu Asn Ser Phe Ala Asp Ile Glu Asn Asn Leu Phe Glu Ala Glu 
                85                  90                  95      

Gly Tyr Asn His Ser Phe Arg Phe Leu Lys Ala Ser His Gln Ile Asp 
            100                 105                 110         

Gln Ile Glu Ser Gln Ile Thr Leu Ile Glu Glu Asp Ile Ala Ala Ile 
        115                 120                 125             

Arg Asn Ala Leu Ala Asp Leu Glu Lys Gln Glu Ser Lys Asn Ser Gly 
    130                 135                 140                 

Arg Val Leu His Ala Leu Asp Leu Phe Glu Glu Leu Gln His Arg Val 
145                 150                 155                 160 

Ala Glu Asn Ser Glu Gln Tyr Gly Gln Ala Leu Asp Glu Ile Glu Lys 
                165                 170                 175     

Gln Leu Glu Asn Ile Gln Ser Glu Phe Ser Gln Phe Val Thr Leu Asn 
            180                 185                 190         

Ser Ser Gly Asp Pro Val Glu Ala Ala Val Ile Leu Asp Asn Thr Glu 
        195                 200                 205             

Asn His Ile Leu Ala Leu Ser His Ile Val Asp Arg Val Pro Ala Leu 
    210                 215                 220                 

Val Thr Thr Leu Ser Thr Glu Leu Pro Asp Gln Leu Gln Asp Leu Glu 
225                 230                 235                 240 

Ala Gly Tyr Arg Lys Leu Ile Asp Ala Asn Tyr His Phe Val Glu Thr 
                245                 250                 255     

Asp Ile Glu Ala Arg Phe His Leu Leu Tyr Glu Ala Phe Lys Lys Asn 
            260                 265                 270         

Gln Glu Asn Ile Arg Gln Leu Glu Leu Asp Asn Ala Glu Tyr Glu Asn 
        275                 280                 285             

Gly Gln Ala Gln Glu Glu Ile Asn Ala Leu Tyr Asp Ile Phe Thr Arg 
    290                 295                 300                 

Glu Ile Ala Ala Gln Lys Val Val Glu Asn Leu Leu Ala Thr Leu Pro 
305                 310                 315                 320 

Thr Tyr Leu Gln His Met Lys Glu Asn Asn Thr Leu Leu Gly Glu Asp 
                325                 330                 335     

Ile Ala Arg Leu Asn Lys Thr Tyr Leu Leu Pro Glu Thr Ala Ala Ser 
            340                 345                 350         

His Val Arg Arg Ile Gln Thr Glu Leu Glu Ser Phe Glu Ala Ala Ile 
        355                 360                 365             

Val Glu Val Thr Ser Asn Gln Glu Glu Pro Thr Gln Ala Tyr Ser Val 
    370                 375                 380                 

Leu Glu Glu Asn Leu Glu Asp Leu Gln Thr Gln Leu Lys Asp Ile Glu 
385                 390                 395                 400 

Asp Glu Gln Ile Ser Val Ser Glu Arg Leu Thr Gln Ile Glu Lys Asp 
                405                 410                 415     

Asp Ile Asn Ala Arg Gln Lys Ala Asn Val Tyr Val Asn Arg Leu His 
            420                 425                 430         

Thr Ile Lys Arg Tyr Met Glu Lys Arg Asn Leu Pro Gly Ile Pro Gln 
        435                 440                 445             

Thr Phe Leu Lys Leu Phe Phe Thr Ala Ser Asn Asn Thr Glu Asp Leu 
    450                 455                 460                 

Met Val Glu Leu Glu Gln Lys Met Ile Asn Ile Glu Ser Val Thr Arg 
465                 470                 475                 480 

Val Leu Glu Ile Ala Thr Asn Asp Met Glu Ala Leu Glu Thr Glu Thr 
                485                 490                 495     

Tyr Asn Ile Val Gln Tyr Ala Thr Leu Thr Glu Gln Leu Leu Gln Tyr 
            500                 505                 510         

Ser Asn Arg Tyr Arg Ser Phe Asp Glu Arg Ile Gln Glu Ala Phe Asn 
        515                 520                 525             

Glu Ala Leu Asp Ile Phe Glu Lys Glu Phe Asp Tyr His Ala Ser Phe 
    530                 535                 540                 

Asp Lys Ile Ser Gln Ala Leu Glu Val Ala Glu Pro Gly Val Thr Asn 
545                 550                 555                 560 

Arg Phe Val Thr Ser Tyr Glu Lys Thr Arg Glu Thr Ile Arg Phe 
                565                 570                 575 

<210>   1541
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1541
atgaaatcaa ctaaagaaga aatccaaacc atcaaaacac ttttaaaaga ctctcgtaca   60
gctaaatatc ataaacgcct tcaaatcgtt cta                                93

<210>   1542
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1542
Met Lys Ser Thr Lys Glu Glu Ile Gln Thr Ile Lys Thr Leu Leu Lys 
1               5                   10                  15      

Asp Ser Arg Thr Ala Lys Tyr His Lys Arg Leu Gln Ile Val Leu 
            20                  25                  30      

<210>   1543
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1543
atgacagttg aggaaaagaa agtctttctt gcccgccatt tgaaggctgc agaggcagga   60
gaatttgtta caattgatgc cttatttcag gcttataaaa aggagttagg tcgttcctac   120
acacgtgatg ccttctatca actgttgaag tgccatggtt ggcgaaatat tatgccacgt   180
ccagaacatc ctaagaaagc agacgctcaa accattgtcg cgtctaaaaa taaaatctca   240
attcaagaag aaaagaaagc gctt                                          264

<210>   1544
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Transposase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902761 (1.E-44)

<400>   1544
Met Thr Val Glu Glu Lys Lys Val Phe Leu Ala Arg His Leu Lys Ala 
1               5                   10                  15      

Ala Glu Ala Gly Glu Phe Val Thr Ile Asp Ala Leu Phe Gln Ala Tyr 
            20                  25                  30          

Lys Lys Glu Leu Gly Arg Ser Tyr Thr Arg Asp Ala Phe Tyr Gln Leu 
        35                  40                  45              

Leu Lys Cys His Gly Trp Arg Asn Ile Met Pro Arg Pro Glu His Pro 
    50                  55                  60                  

Lys Lys Ala Asp Ala Gln Thr Ile Val Ala Ser Lys Asn Lys Ile Ser 
65                  70                  75                  80  

Ile Gln Glu Glu Lys Lys Ala Leu 
                85              

<210>   1545
<211>   510
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1545
ttgatgtacc aagatgaggc tggtttcggt agaatcagta aactgggatc ttgttgggct   60
ccaataggag taggtccaca tatccatagt cactatatac gagaatttcg ctattgttat   120
ggagctgttg atgcccatac aggcgaatca tttttcttaa tagctggtag atgtaatact   180
gagtggatga acgccttttt agaagagctt tcacaagctt atccagatga ttatctttta   240
ctcgttatgg acaatgctat atggcataaa tcaagtacct taaagattcc gactaatatt   300
ggttttacct ttattcctcc atacacacca gagatgaacc ccattgaaca agtgtggaaa   360
gagattcgta aacgtggatt taagaataaa gcctttcaaa ctttggaaga tgtcatgaat   420
caactccaag atgttataca aggattggag aaggaggtga taaagtccat cgttaatcgg   480
agatggacta gaatgctttt tgaaaacaga                                    510

<210>   1546
<211>   170
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902762 (2.E-94)

<400>   1546
Met Met Tyr Gln Asp Glu Ala Gly Phe Gly Arg Ile Ser Lys Leu Gly 
1               5                   10                  15      

Ser Cys Trp Ala Pro Ile Gly Val Gly Pro His Ile His Ser His Tyr 
            20                  25                  30          

Ile Arg Glu Phe Arg Tyr Cys Tyr Gly Ala Val Asp Ala His Thr Gly 
        35                  40                  45              

Glu Ser Phe Phe Leu Ile Ala Gly Arg Cys Asn Thr Glu Trp Met Asn 
    50                  55                  60                  

Ala Phe Leu Glu Glu Leu Ser Gln Ala Tyr Pro Asp Asp Tyr Leu Leu 
65                  70                  75                  80  

Leu Val Met Asp Asn Ala Ile Trp His Lys Ser Ser Thr Leu Lys Ile 
                85                  90                  95      

Pro Thr Asn Ile Gly Phe Thr Phe Ile Pro Pro Tyr Thr Pro Glu Met 
            100                 105                 110         

Asn Pro Ile Glu Gln Val Trp Lys Glu Ile Arg Lys Arg Gly Phe Lys 
        115                 120                 125             

Asn Lys Ala Phe Gln Thr Leu Glu Asp Val Met Asn Gln Leu Gln Asp 
    130                 135                 140                 

Val Ile Gln Gly Leu Glu Lys Glu Val Ile Lys Ser Ile Val Asn Arg 
145                 150                 155                 160 

Arg Trp Thr Arg Met Leu Phe Glu Asn Arg 
                165                 170 

<210>   1547
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1547
atgataattc aactaagtga tttaggtcaa gttcaccttg tttgtggcaa gacagatatg   60
aggcagggaa tagactcatt agcctatgta gttaaaaccc actttgaatt ggattctttc   120
tccggtcaag tctttctctt ttgtggtgga cgtaaagacc gctttaaagc cctttactgg   180
gatggtcaag gattttggct actatataaa cgctttgaga acggaaaact gacttggcta   240
agtacagaaa aagatgtcaa agctctcgca cctgaacaag tagac                   285

<210>   1548
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf2, interruption
<223>   Cellular location: cytoplasm

<400>   1548
Met Ile Ile Gln Leu Ser Asp Leu Gly Gln Val His Leu Val Cys Gly 
1               5                   10                  15      

Lys Thr Asp Met Arg Gln Gly Ile Asp Ser Leu Ala Tyr Val Val Lys 
            20                  25                  30          

Thr His Phe Glu Leu Asp Ser Phe Ser Gly Gln Val Phe Leu Phe Cys 
        35                  40                  45              

Gly Gly Arg Lys Asp Arg Phe Lys Ala Leu Tyr Trp Asp Gly Gln Gly 
    50                  55                  60                  

Phe Trp Leu Leu Tyr Lys Arg Phe Glu Asn Gly Lys Leu Thr Trp Leu 
65                  70                  75                  80  

Ser Thr Glu Lys Asp Val Lys Ala Leu Ala Pro Glu Gln Val Asp 
                85                  90                  95  

<210>   1549
<211>   513
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1549
atgaaattaa gttatgatga taaagttcag atctatgaac ttagaaaaca aggatatagc   60
ttagagaagc tttcaaataa atttgggata aataattcta atcttaggta tatgattaaa   120
ttgattgatc gttacggaat agagttcgtc aaaaaaggaa aaaatcgtta ctattttcct   180
gatttaaaac aagaaatgat taataaagtc ttacatgaag gctgaactaa agatagagtt   240
tctcttgaat acggtctccc aagtcgtacg atacttctta actggctagc acaatacaga   300
aaaaacgggt atactattgt tgagaaaaca agagggagag tacctaaaat gggacgtaag   360
ccaaaaaaga gacctgaaga gagaacagaa ttagaacgtc ttcaagcaga aaatgagtac   420
ctgagagcgg agaatgctat cctaaaaaag ttaagagaac tccgatggaa ggaggaaaaa   480
gagaaagaag aaagacagaa attgttcaag aat                                513


<210>   1550
<400>   1550
000

<210>   1551
<211>   820
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1551
atgactgagt tttcgttaga tcttcttcta aaagccatta aactagctcg ttggacctac   60
tactatcact tgaaacagct agacaaacca gataaggacc aagagcttaa agctgaaatt   120
caatccattt ttatcgaaca caagggaaat tatggttatc gtcggattta tttagaacta   180
agaaatcgtg gttatctggt aaatcataaa agagttcaag gcttgatgaa agtactcaat   240
ttacaagcta aaatgcgaca gaaacgaaaa taaaggagac gttggtaaga aggcagagaa   300
tctcattcaa ggccaatttg aaggctctaa aacaatggaa aagtgctaca cagatgtgac   360
agaatttgcc attccagcaa gtactcaaaa gctttactta tcaccagttt tagatggctt   420
taatagcgaa attattgctt ttaatctttc gacttcaccc aacttagaac aagtacaaac   480
aatgttagaa caggcattca aagagaagca ctacgagaat acgattctcc atagtgacca   540
aggctggcaa tatcaacacg attcttatca tcggttccta gagagtaagg gaattcaagc   600
atctatgtca cgcaagggca acagccaaga caacggtatg atggaatctt tctttggcat   660
tttaaaatcc gaaatgtttt atggctatga gaaaacattt aaatcactta accaattgga   720
acaagccatt atagactata ttgattacta caacaacaaa cgaattaagg taaaactaaa   780
aggacttagt cctgtgcagt acagaactaa atcctttgga                         820

<210>   1552
<211>   90
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, transposase FRAMESHIFT

<400>   1552
Met Thr Glu Phe Ser Leu Asp Leu Leu Leu Lys Ala Ile Lys Leu Ala 
1               5                   10                  15      

Arg Trp Thr Tyr Tyr Tyr His Leu Lys Gln Leu Asp Lys Pro Asp Lys 
            20                  25                  30          

Asp Gln Glu Leu Lys Ala Glu Ile Gln Ser Ile Phe Ile Glu His Lys 
        35                  40                  45              

Gly Asn Tyr Gly Tyr Arg Arg Ile Tyr Leu Glu Leu Arg Asn Arg Gly 
    50                  55                  60                  

Tyr Leu Val Asn His Lys Arg Val Gln Gly Leu Met Lys Val Leu Asn 
65                  70                  75                  80  

Leu Gln Ala Lys Met Arg Gln Lys Arg Lys 
                85                  90  

<210>   1553
<211>   486
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   1553
atggaaaagt gctacacaga tgtgacagaa tttgccattc cagcaagtac tcaaaagctt   60
tacttatcac cagttttaga tggctttaat agcgaaatta ttgcttttaa tctttcgact   120
tcacccaact tagaacaagt acaaacaatg ttagaacagg cattcaaaga gaagcactac   180
gagaatacga ttctccatag tgaccaaggc tggcaatatc aacacgattc ttatcatcgg   240
ttcctagaga gtaagggaat tcaagcatct atgtcacgca agggcaacag ccaagacaac   300
ggtatgatgg aatctttctt tggcatttta aaatccgaaa tgttttatgg ctatgagaaa   360
acatttaaat cacttaacca attggaacaa gccattatag actatattga ttactacaac   420
aacaaacgaa ttaaggtaaa actaaaagga cttagtcctg tgcagtacag aactaaatcc   480
tttgga                                                              486

<210>   1554
<211>   162
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   probable transposase (insertionsequen)

<400>   1554
Met Glu Lys Cys Tyr Thr Asp Val Thr Glu Phe Ala Ile Pro Ala Ser 
1               5                   10                  15      

Thr Gln Lys Leu Tyr Leu Ser Pro Val Leu Asp Gly Phe Asn Ser Glu 
            20                  25                  30          

Ile Ile Ala Phe Asn Leu Ser Thr Ser Pro Asn Leu Glu Gln Val Gln 
        35                  40                  45              

Thr Met Leu Glu Gln Ala Phe Lys Glu Lys His Tyr Glu Asn Thr Ile 
    50                  55                  60                  

Leu His Ser Asp Gln Gly Trp Gln Tyr Gln His Asp Ser Tyr His Arg 
65                  70                  75                  80  

Phe Leu Glu Ser Lys Gly Ile Gln Ala Ser Met Ser Arg Lys Gly Asn 
                85                  90                  95      

Ser Gln Asp Asn Gly Met Met Glu Ser Phe Phe Gly Ile Leu Lys Ser 
            100                 105                 110         

Glu Met Phe Tyr Gly Tyr Glu Lys Thr Phe Lys Ser Leu Asn Gln Leu 
        115                 120                 125             

Glu Gln Ala Ile Ile Asp Tyr Ile Asp Tyr Tyr Asn Asn Lys Arg Ile 
    130                 135                 140                 

Lys Val Lys Leu Lys Gly Leu Ser Pro Val Gln Tyr Arg Thr Lys Ser 
145                 150                 155                 160 

Phe Gly 
        

<210>   1555
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1555
ttgctactat gcgttttatt attgaaagac ttattggact ttctctcaaa tcgagttttt   60
actcaatttt cttacttgat tgggattgaa attccaatta atttctctga g            111

<210>   1556
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Transposase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903342 (1.E-38)

<400>   1556
Met Leu Leu Cys Val Leu Leu Leu Lys Asp Leu Leu Asp Phe Leu Ser 
1               5                   10                  15      

Asn Arg Val Phe Thr Gln Phe Ser Tyr Leu Ile Gly Ile Glu Ile Pro 
            20                  25                  30          

Ile Asn Phe Ser Glu 
        35          

<210>   1557
<211>   297
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1557
atgaagctta tcaatacgac aaactcacac tcgcaacttg taaaaagtca gctagaaagt   60
accgatgcaa cccttgttga ggtttattct gcagggaata cagatgttat ttttacccaa   120
gctccgcttc actatgaaat cctcatctca aacaaacacc gtgctattcg tgagcctgaa   180
atcgaaacca ttcaagaatt tttcttgaaa cgtaaaattg ataaggcctc tgttgatgaa   240
gccaatatca agacactcta ctcagagaaa ttaattggaa tttcaatccc aatcaag      297

<210>   1558
<211>   99
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902764 (9.E-51)

<400>   1558
Met Lys Leu Ile Asn Thr Thr Asn Ser His Ser Gln Leu Val Lys Ser 
1               5                   10                  15      

Gln Leu Glu Ser Thr Asp Ala Thr Leu Val Glu Val Tyr Ser Ala Gly 
            20                  25                  30          

Asn Thr Asp Val Ile Phe Thr Gln Ala Pro Leu His Tyr Glu Ile Leu 
        35                  40                  45              

Ile Ser Asn Lys His Arg Ala Ile Arg Glu Pro Glu Ile Glu Thr Ile 
    50                  55                  60                  

Gln Glu Phe Phe Leu Lys Arg Lys Ile Asp Lys Ala Ser Val Asp Glu 
65                  70                  75                  80  

Ala Asn Ile Lys Thr Leu Tyr Ser Glu Lys Leu Ile Gly Ile Ser Ile 
                85                  90                  95      

Pro Ile Lys 
            

<210>   1559
<211>   420
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1559
gtgaatacag actatattgc tcgctatggc gtatatgcag ttatccctaa tcctgaacaa   60
aaacaaattg ttcttgttca agaaccaaat ggtgcttggt tcctaccatg tggagaaatt   120
gaagcaggtg aaaatcatca ggaagcccta aagcatgagt tgattgaaga gcttggtttc   180
acagcagaaa ttggtaccta ttacggacaa gctgacgaat atttctattc tcgtcatcgt   240
gatacctact actacaatcc tgcctacctc tatgaagcaa ctcctttcaa agaagtacaa   300
aagccactag aaaactttaa tcatattgcc tggttcccta ttgacgaggc tatcaaaaac   360
cttaaacgtg gtagccataa atgggccatt gaatcttgga aaaaacagca taagattggc   420

<210>   1560
<211>   140
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MutT/nudix family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902765 (1.E-82)

<400>   1560
Met Asn Thr Asp Tyr Ile Ala Arg Tyr Gly Val Tyr Ala Val Ile Pro 
1               5                   10                  15      

Asn Pro Glu Gln Lys Gln Ile Val Leu Val Gln Glu Pro Asn Gly Ala 
            20                  25                  30          

Trp Phe Leu Pro Cys Gly Glu Ile Glu Ala Gly Glu Asn His Gln Glu 
        35                  40                  45              

Ala Leu Lys His Glu Leu Ile Glu Glu Leu Gly Phe Thr Ala Glu Ile 
    50                  55                  60                  

Gly Thr Tyr Tyr Gly Gln Ala Asp Glu Tyr Phe Tyr Ser Arg His Arg 
65                  70                  75                  80  

Asp Thr Tyr Tyr Tyr Asn Pro Ala Tyr Leu Tyr Glu Ala Thr Pro Phe 
                85                  90                  95      

Lys Glu Val Gln Lys Pro Leu Glu Asn Phe Asn His Ile Ala Trp Phe 
            100                 105                 110         

Pro Ile Asp Glu Ala Ile Lys Asn Leu Lys Arg Gly Ser His Lys Trp 
        115                 120                 125             

Ala Ile Glu Ser Trp Lys Lys Gln His Lys Ile Gly 
    130                 135                 140 

<210>   1561
<211>   348
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1561
atgtggtata atcttcttat ggcatattca atagattttc gtaaaaaagt tctctcttat   60
tgtgagcgaa caggtagtat aacagaagca tcacacgttt tccaaatctc acgtaatacc   120
atttatggct ggttaaagct aaaagagaaa acaggagagc taaaccacca agtaaaagga   180
ataaaaccaa gaaaggttga tagagataga cttaaaaact atcttactga caatccagac   240
gcttatttga ctgaaatagc ttctgaattt ggctgtcatc caactaccat ccactatgcg   300
ctcaaagcta tgggctacac tcgaaaaaaa aaagaactac acctacta                348

<210>   1562
<211>   116
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1 FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902766 (1.E-62)

<400>   1562
Met Trp Tyr Asn Leu Leu Met Ala Tyr Ser Ile Asp Phe Arg Lys Lys 
1               5                   10                  15      

Val Leu Ser Tyr Cys Glu Arg Thr Gly Ser Ile Thr Glu Ala Ser His 
            20                  25                  30          

Val Phe Gln Ile Ser Arg Asn Thr Ile Tyr Gly Trp Leu Lys Leu Lys 
        35                  40                  45              

Glu Lys Thr Gly Glu Leu Asn His Gln Val Lys Gly Ile Lys Pro Arg 
    50                  55                  60                  

Lys Val Asp Arg Asp Arg Leu Lys Asn Tyr Leu Thr Asp Asn Pro Asp 
65                  70                  75                  80  

Ala Tyr Leu Thr Glu Ile Ala Ser Glu Phe Gly Cys His Pro Thr Thr 
                85                  90                  95      

Ile His Tyr Ala Leu Lys Ala Met Gly Tyr Thr Arg Lys Lys Lys Glu 
            100                 105                 110         

Leu His Leu Leu 
        115     

<210>   1563
<211>   321
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1563
atgaatggtg agttaatcgc tccaatgact tacgaagaga cgatgacgag cgactttttt   60
gaagcttggt ttcagaagtt tctcttacca acattaacca caccatcggt tattattatg   120
gataatgcaa gattccatag aatgggtaag ttagaactct tgtgtgaaga gtttgggtat   180
aaacttttac ctcttcctcc ctactcacct gagtacaatc ctattgagaa aacatgggct   240
catatcaaaa agcacctcaa aaaggtatta ccaagttgca atacctttta tgaggctctt   300
ttgtcttgtt cttgtttcaa t                                             321

<210>   1564
<211>   107
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903869 (2.E-61)

<400>   1564
Met Asn Gly Glu Leu Ile Ala Pro Met Thr Tyr Glu Glu Thr Met Thr 
1               5                   10                  15      

Ser Asp Phe Phe Glu Ala Trp Phe Gln Lys Phe Leu Leu Pro Thr Leu 
            20                  25                  30          

Thr Thr Pro Ser Val Ile Ile Met Asp Asn Ala Arg Phe His Arg Met 
        35                  40                  45              

Gly Lys Leu Glu Leu Leu Cys Glu Glu Phe Gly Tyr Lys Leu Leu Pro 
    50                  55                  60                  

Leu Pro Pro Tyr Ser Pro Glu Tyr Asn Pro Ile Glu Lys Thr Trp Ala 
65                  70                  75                  80  

His Ile Lys Lys His Leu Lys Lys Val Leu Pro Ser Cys Asn Thr Phe 
                85                  90                  95      

Tyr Glu Ala Leu Leu Ser Cys Ser Cys Phe Asn 
            100                 105         

<210>   1565
<211>   2256
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1565
atgctttgtc aaaactgtaa aattaacgac tcaacaattc atctttacac caatctcaat   60
ggaaaacaaa aacaaattga cctctgtcaa aactgctata agattatcaa aacagatcct   120
aacaatagcc tcttcaaagg tatgacggat ctgaacaatc gtgacttcga tccctttggt   180
gatttcttca atgatctaaa caatttcaga ccttctagca atactcctcc tattccccca   240
acccaatcag gtggaggtta cggtggaaac ggcggttatg gttcccaaaa tcgtggatct   300
gctcaaactc cgccacctag ccaagaaaaa ggcctgctgg aagaatttgg tattaatgta   360
actgaaattg cccgtcgtgg agacattgac cccgttattg ggcgcgacga tgagattatc   420
cgtgtcatcg agattctcaa tcgtagaacc aagaataatc ctgtccttat cggtgaacct   480
ggtgtcggaa aaacggccgt tgtcgaaggt ctagctcaga aaattgtcga tggcgatgtg   540
ccacataaac tccaaggtaa acaagtcatc cgtctggatg tggttagctt agttcaagga   600
acggggattc gaggacaatt tgaagaacgc atgcaaaaac tcatggaaga aattcgcaaa   660
cgtgaagaca tcatcctctt tatcgatgaa atccatgaaa ttgttggtgc tggttctgcg   720
agtgatggta atatggacgc aggaaatatc ctcaagccag cccttgctcg tggagaactg   780
caactagtcg gtgctactac cctcaatgaa taccgtatca ttgaaaagga tgctgccctc   840
gagcgtcgta tgcagcctgt taaagtcgat gaaccaacgg tggacgaaac aatcactatt   900
ctcaaaggga ttcaaaagaa atacgaagat taccaccacg ttcaatatac agatgctgcg   960
attgaagcag ctgcaactct ttccaatcgc tacatccaag atcgcttctt gcctgacaag   1020
gccattgacc tcctagatga agctggttct aagatgaact tgaccttgaa ttttgtggat   1080
cctaaagtaa ttgatcagcg cttgattgag gctgaaaatc tcaagtctca agctacacga   1140
gaagaagatt ttgagaaggc ggcctacttc cgcgaccaga ttgccaagta taaggaaatg   1200
caaaagaaaa agatcacaga ccaggatact cctagcatca gcgagaaaac tattgagcac   1260
attatcgagc agaaaaccaa tatccctgtt ggtgatttga aagagaaaga acaatctcaa   1320
ctcatccatc tagccgaaga tctcaagtct catgttattg gtcaagatga tgcagtcgat   1380
aagattgcca aggctattcg ccgtaatcgt gtcggacttg gtacccctaa ccgcccaatc   1440
ggaagcttcc tcttcgttgg gccaactggt gtcggtaaga cagaactttc caaacaactg   1500
gctatcgaac tttttggttc tgctgatagt atgattcgct ttgatatgag tgaatacatg   1560
gaaaaacata gtgtggctaa gttggtcggc gctcctccag gttatgttgg ctatgatgag   1620
gctggtcaat taactgaaaa agttcgccac aatccatatt ctctcatcct tctcgatgaa   1680
gtggaaaaag ctcacccaga tgttatgcac atgtttcttc aagtcttgga cgatggtcgt   1740
ttgacagacg ggcaaggacg caccgttagc ttcaaggatg ccatcattat catgacctca   1800
aatgcaggta caggaaagac cgaagctagc gttggatttg gtgctgctag agaaggacgt   1860
accaattctg tcctcggtga actcggtaac ttctttagcc cagagtttat gaaccgtttt   1920
gatggcatta tcgaatttaa ggctctcagc aaggataacc tccttcagat tgtcgagctc   1980
atgctagcag atgttaacaa gcgcctctct agcaacaaca ttcgtttgga tgtaactgat   2040
aaggtcaagg aaaagttggt tgacctaggt tatgatccaa aaatgggagc acgcccactt   2100
cgtcggacta ttcaagacta tattgaggac acaatcactg actactacct tgaaaatcca   2160
agcgaaaaag atctcaaagc agttatgact agcaagggaa acattcagat taaatctgcc   2220
aaaaaagctg aagttaaaag ttctgaaaaa gaaaaa                             2256

<210>   1566
<211>   752
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent Clp protease, ATP-binding subunit ClpE (clpE)
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15902769 (0.E+01)

<400>   1566
Met Leu Cys Gln Asn Cys Lys Ile Asn Asp Ser Thr Ile His Leu Tyr 
1               5                   10                  15      

Thr Asn Leu Asn Gly Lys Gln Lys Gln Ile Asp Leu Cys Gln Asn Cys 
            20                  25                  30          

Tyr Lys Ile Ile Lys Thr Asp Pro Asn Asn Ser Leu Phe Lys Gly Met 
        35                  40                  45              

Thr Asp Leu Asn Asn Arg Asp Phe Asp Pro Phe Gly Asp Phe Phe Asn 
    50                  55                  60                  

Asp Leu Asn Asn Phe Arg Pro Ser Ser Asn Thr Pro Pro Ile Pro Pro 
65                  70                  75                  80  

Thr Gln Ser Gly Gly Gly Tyr Gly Gly Asn Gly Gly Tyr Gly Ser Gln 
                85                  90                  95      

Asn Arg Gly Ser Ala Gln Thr Pro Pro Pro Ser Gln Glu Lys Gly Leu 
            100                 105                 110         

Leu Glu Glu Phe Gly Ile Asn Val Thr Glu Ile Ala Arg Arg Gly Asp 
        115                 120                 125             

Ile Asp Pro Val Ile Gly Arg Asp Asp Glu Ile Ile Arg Val Ile Glu 
    130                 135                 140                 

Ile Leu Asn Arg Arg Thr Lys Asn Asn Pro Val Leu Ile Gly Glu Pro 
145                 150                 155                 160 

Gly Val Gly Lys Thr Ala Val Val Glu Gly Leu Ala Gln Lys Ile Val 
                165                 170                 175     

Asp Gly Asp Val Pro His Lys Leu Gln Gly Lys Gln Val Ile Arg Leu 
            180                 185                 190         

Asp Val Val Ser Leu Val Gln Gly Thr Gly Ile Arg Gly Gln Phe Glu 
        195                 200                 205             

Glu Arg Met Gln Lys Leu Met Glu Glu Ile Arg Lys Arg Glu Asp Ile 
    210                 215                 220                 

Ile Leu Phe Ile Asp Glu Ile His Glu Ile Val Gly Ala Gly Ser Ala 
225                 230                 235                 240 

Ser Asp Gly Asn Met Asp Ala Gly Asn Ile Leu Lys Pro Ala Leu Ala 
                245                 250                 255     

Arg Gly Glu Leu Gln Leu Val Gly Ala Thr Thr Leu Asn Glu Tyr Arg 
            260                 265                 270         

Ile Ile Glu Lys Asp Ala Ala Leu Glu Arg Arg Met Gln Pro Val Lys 
        275                 280                 285             

Val Asp Glu Pro Thr Val Asp Glu Thr Ile Thr Ile Leu Lys Gly Ile 
    290                 295                 300                 

Gln Lys Lys Tyr Glu Asp Tyr His His Val Gln Tyr Thr Asp Ala Ala 
305                 310                 315                 320 

Ile Glu Ala Ala Ala Thr Leu Ser Asn Arg Tyr Ile Gln Asp Arg Phe 
                325                 330                 335     

Leu Pro Asp Lys Ala Ile Asp Leu Leu Asp Glu Ala Gly Ser Lys Met 
            340                 345                 350         

Asn Leu Thr Leu Asn Phe Val Asp Pro Lys Val Ile Asp Gln Arg Leu 
        355                 360                 365             

Ile Glu Ala Glu Asn Leu Lys Ser Gln Ala Thr Arg Glu Glu Asp Phe 
    370                 375                 380                 

Glu Lys Ala Ala Tyr Phe Arg Asp Gln Ile Ala Lys Tyr Lys Glu Met 
385                 390                 395                 400 

Gln Lys Lys Lys Ile Thr Asp Gln Asp Thr Pro Ser Ile Ser Glu Lys 
                405                 410                 415     

Thr Ile Glu His Ile Ile Glu Gln Lys Thr Asn Ile Pro Val Gly Asp 
            420                 425                 430         

Leu Lys Glu Lys Glu Gln Ser Gln Leu Ile His Leu Ala Glu Asp Leu 
        435                 440                 445             

Lys Ser His Val Ile Gly Gln Asp Asp Ala Val Asp Lys Ile Ala Lys 
    450                 455                 460                 

Ala Ile Arg Arg Asn Arg Val Gly Leu Gly Thr Pro Asn Arg Pro Ile 
465                 470                 475                 480 

Gly Ser Phe Leu Phe Val Gly Pro Thr Gly Val Gly Lys Thr Glu Leu 
                485                 490                 495     

Ser Lys Gln Leu Ala Ile Glu Leu Phe Gly Ser Ala Asp Ser Met Ile 
            500                 505                 510         

Arg Phe Asp Met Ser Glu Tyr Met Glu Lys His Ser Val Ala Lys Leu 
        515                 520                 525             

Val Gly Ala Pro Pro Gly Tyr Val Gly Tyr Asp Glu Ala Gly Gln Leu 
    530                 535                 540                 

Thr Glu Lys Val Arg His Asn Pro Tyr Ser Leu Ile Leu Leu Asp Glu 
545                 550                 555                 560 

Val Glu Lys Ala His Pro Asp Val Met His Met Phe Leu Gln Val Leu 
                565                 570                 575     

Asp Asp Gly Arg Leu Thr Asp Gly Gln Gly Arg Thr Val Ser Phe Lys 
            580                 585                 590         

Asp Ala Ile Ile Ile Met Thr Ser Asn Ala Gly Thr Gly Lys Thr Glu 
        595                 600                 605             

Ala Ser Val Gly Phe Gly Ala Ala Arg Glu Gly Arg Thr Asn Ser Val 
    610                 615                 620                 

Leu Gly Glu Leu Gly Asn Phe Phe Ser Pro Glu Phe Met Asn Arg Phe 
625                 630                 635                 640 

Asp Gly Ile Ile Glu Phe Lys Ala Leu Ser Lys Asp Asn Leu Leu Gln 
                645                 650                 655     

Ile Val Glu Leu Met Leu Ala Asp Val Asn Lys Arg Leu Ser Ser Asn 
            660                 665                 670         

Asn Ile Arg Leu Asp Val Thr Asp Lys Val Lys Glu Lys Leu Val Asp 
        675                 680                 685             

Leu Gly Tyr Asp Pro Lys Met Gly Ala Arg Pro Leu Arg Arg Thr Ile 
    690                 695                 700                 

Gln Asp Tyr Ile Glu Asp Thr Ile Thr Asp Tyr Tyr Leu Glu Asn Pro 
705                 710                 715                 720 

Ser Glu Lys Asp Leu Lys Ala Val Met Thr Ser Lys Gly Asn Ile Gln 
                725                 730                 735     

Ile Lys Ser Ala Lys Lys Ala Glu Val Lys Ser Ser Glu Lys Glu Lys 
            740                 745                 750         


<210>   1567
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1567
atgaaaattt ttgtgaattt ggactataaa aaaatcctat ttgtgagaca aaaaggattt   60
tacttagaca tgcagggaca atcccagctt gttttagat                          99

<210>   1568
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1568
Met Lys Ile Phe Val Asn Leu Asp Tyr Lys Lys Ile Leu Phe Val Arg 
1               5                   10                  15      

Gln Lys Gly Phe Tyr Leu Asp Met Gln Gly Gln Ser Gln Leu Val Leu 
            20                  25                  30          

Asp 
    

<210>   1569

<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1569
atggaatcac atttggttag aatcatcaac cgccttgaag caatggcaaa cgatggcgga   60
aatttaaaac gtaattttga acgcgaagga gttgttgttg cagaagttgc gtacagccac   120
gacgaagaaa acggcccaat ctttaccctt cgtgacgtag aagatcgcga aacgtatacg   180
tttgatagca ttgacttaat cgcaatggaa atttacgaac ttctctac                228

<210>   1570
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902770 (1.E-39)

<400>   1570
Met Glu Ser His Leu Val Arg Ile Ile Asn Arg Leu Glu Ala Met Ala 
1               5                   10                  15      

Asn Asp Gly Gly Asn Leu Lys Arg Asn Phe Glu Arg Glu Gly Val Val 
            20                  25                  30          

Val Ala Glu Val Ala Tyr Ser His Asp Glu Glu Asn Gly Pro Ile Phe 
        35                  40                  45              

Thr Leu Arg Asp Val Glu Asp Arg Glu Thr Tyr Thr Phe Asp Ser Ile 
    50                  55                  60                  

Asp Leu Ile Ala Met Glu Ile Tyr Glu Leu Leu Tyr 
65                  70                  75      

<210>   1571
<211>   687
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1571
gtgactatga atttttcttt tttacctaag tatttacctt attttaacta tggggctgtt   60
gtgacgattc ttatttctat ctgtgttatc tttttgggaa ctattttggg tgttgtcttg   120
gcttttgggc aacgttcaaa gtttaaaccg cttgtttggt tggccaactt gtacgtttgg   180
attttccgtg ggacaccgat gatggttcaa attatgattg cctttgctct tatgcatatc   240
aatgctccga ctattcagat tggaatttta ggtgttgatt tttcgcgtct gattccaggg   300
attttgatta tctctatgaa tagtggtgct tatgtttcgg agactgttcg tgccggaatc   360
aatgcggttc caaaaggtca gctagaagcg gcttattcgc tagggattcg tcctaaaaat   420
gcgatgcgtt atgtgatttt gccacaagca gtcaaaaata tcttgccagc attggggaac   480
gaatttatca ccattatcaa ggacagctcc ctcttatcag ctattggggt catggagttg   540
tggaatgggg ctacaacagt ttctacaaca acctatctac ctttaacacc acttttattt   600
gcagcatttt actacttgat tatgacctct attctgacag tagccttgaa agcttttgaa   660
aaacatatgg gacaaggaga taagaaa                                       687

<210>   1572
<211>   229
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902771 (e-127)

<400>   1572
Met Thr Met Asn Phe Ser Phe Leu Pro Lys Tyr Leu Pro Tyr Phe Asn 
1               5                   10                  15      

Tyr Gly Ala Val Val Thr Ile Leu Ile Ser Ile Cys Val Ile Phe Leu 
            20                  25                  30          

Gly Thr Ile Leu Gly Val Val Leu Ala Phe Gly Gln Arg Ser Lys Phe 
        35                  40                  45              

Lys Pro Leu Val Trp Leu Ala Asn Leu Tyr Val Trp Ile Phe Arg Gly 
    50                  55                  60                  

Thr Pro Met Met Val Gln Ile Met Ile Ala Phe Ala Leu Met His Ile 
65                  70                  75                  80  

Asn Ala Pro Thr Ile Gln Ile Gly Ile Leu Gly Val Asp Phe Ser Arg 
                85                  90                  95      

Leu Ile Pro Gly Ile Leu Ile Ile Ser Met Asn Ser Gly Ala Tyr Val 
            100                 105                 110         

Ser Glu Thr Val Arg Ala Gly Ile Asn Ala Val Pro Lys Gly Gln Leu 
        115                 120                 125             

Glu Ala Ala Tyr Ser Leu Gly Ile Arg Pro Lys Asn Ala Met Arg Tyr 
    130                 135                 140                 

Val Ile Leu Pro Gln Ala Val Lys Asn Ile Leu Pro Ala Leu Gly Asn 
145                 150                 155                 160 

Glu Phe Ile Thr Ile Ile Lys Asp Ser Ser Leu Leu Ser Ala Ile Gly 
                165                 170                 175     

Val Met Glu Leu Trp Asn Gly Ala Thr Thr Val Ser Thr Thr Thr Tyr 
            180                 185                 190         

Leu Pro Leu Thr Pro Leu Leu Phe Ala Ala Phe Tyr Tyr Leu Ile Met 
        195                 200                 205             

Thr Ser Ile Leu Thr Val Ala Leu Lys Ala Phe Glu Lys His Met Gly 
    210                 215                 220                 

Gln Gly Asp Lys Lys 
225                 

<210>   1573
<211>   732
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1573
atgacagaaa ccttgataaa aattgaaaat ttacataaat cctttggaaa gaatgaagta   60
ttgaagggca tcaacctcga gattaaaaga ggagaagttg tcgttatcat cggtccttca   120
gggagcggga aatctacctt gcttcgctct atgaatttgt tggaagaagc aaccaagggg   180
aaggttatct ttgagggagt cgatattacg gacaagaaga atgacctgtt tgccatgcgt   240
gagaagatgg gcatggtttt tcaacaattc aatctctttc ctaatatgac tgtgatggaa   300
aatatcacct tgtcccctat caagaccaaa ggtgacagta aggccgttgc agagaaaaga   360
gctcaggaac ttttggaaaa agttggtttg ccagataagg cagacgctta tccacagagt   420
ttgtcaggtg gccagcaaca gcggattgcc atcgcgcgtg ggttggctat ggaaccagat   480
gttttgctct ttgacgagcc aacttcagcc ctagatcctg agatggttgg agaagttctg   540
gctgttatgc aagatctagc caagtcagga atgaccatgg ttatcgtaac acatgagatg   600
ggatttgccc gtgaggtggc agatcgtgtc atctttatgg cagacggtgt ggttgttgaa   660
gacggaacac ctgagcagat ttttgaacaa acccaaggac aaaggactaa agacttcttg   720
agtaaggttt ta                                                       732

<210>   1574
<211>   244
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902772 (e-131)

<400>   1574
Met Thr Glu Thr Leu Ile Lys Ile Glu Asn Leu His Lys Ser Phe Gly 
1               5                   10                  15      

Lys Asn Glu Val Leu Lys Gly Ile Asn Leu Glu Ile Lys Arg Gly Glu 
            20                  25                  30          

Val Val Val Ile Ile Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Leu 
        35                  40                  45              

Arg Ser Met Asn Leu Leu Glu Glu Ala Thr Lys Gly Lys Val Ile Phe 
    50                  55                  60                  

Glu Gly Val Asp Ile Thr Asp Lys Lys Asn Asp Leu Phe Ala Met Arg 
65                  70                  75                  80  

Glu Lys Met Gly Met Val Phe Gln Gln Phe Asn Leu Phe Pro Asn Met 
                85                  90                  95      

Thr Val Met Glu Asn Ile Thr Leu Ser Pro Ile Lys Thr Lys Gly Asp 
            100                 105                 110         

Ser Lys Ala Val Ala Glu Lys Arg Ala Gln Glu Leu Leu Glu Lys Val 
        115                 120                 125             

Gly Leu Pro Asp Lys Ala Asp Ala Tyr Pro Gln Ser Leu Ser Gly Gly 
    130                 135                 140                 

Gln Gln Gln Arg Ile Ala Ile Ala Arg Gly Leu Ala Met Glu Pro Asp 
145                 150                 155                 160 

Val Leu Leu Phe Asp Glu Pro Thr Ser Ala Leu Asp Pro Glu Met Val 
                165                 170                 175     

Gly Glu Val Leu Ala Val Met Gln Asp Leu Ala Lys Ser Gly Met Thr 
            180                 185                 190         

Met Val Ile Val Thr His Glu Met Gly Phe Ala Arg Glu Val Ala Asp 
        195                 200                 205             

Arg Val Ile Phe Met Ala Asp Gly Val Val Val Glu Asp Gly Thr Pro 
    210                 215                 220                 

Glu Gln Ile Phe Glu Gln Thr Gln Gly Gln Arg Thr Lys Asp Phe Leu 
225                 230                 235                 240 

Ser Lys Val Leu 
                

<210>   1575
<211>   855
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1575
atgacacaga ttattgatgg gaaagcttta gcggccaaat tgcaggggca gttggctgaa   60
aagactgcaa aattaaagga agaaacaggt ctagtgcctg gtttggtagt gattttggtt   120
ggggacaatc cagccagcca agtctacgtt cgcaacaagg agaggtcagc ccttgcggct   180
ggtttccgta gcgaagtagt acgggttcca gagaccatta ctcaagagga attgttagac   240
ctgattgcta aatacaatca ggatccagct tggcatggga ttttggttca gttgccatta   300
ccaaaacaca ttgatgaaga ggcggttcta ttggctattg acccagaaaa ggatgtggat   360
ggtttccatc ctctaaacat ggggcgtctt tggtctggtc atccagtcat gattccttcg   420
acaccggcag gaattatgga aatgttccat gaatatggga ttgacttgga aggtaaaaat   480
gcagtcgtca tcggtcgatc caatattgtc ggaaaaccta tggcccagct tcttttggca   540
aagaatgcaa cagtaacctt gactcactca cgtactcata atctttccaa ggtggctgca   600
aaagcagata ttctggttgt tgcaatcggt cgtgccaagt ttgtgactgc tgactttgtc   660
aaaccaggtg cggtagtcat tgacgttggg atgaaccgcg atgaaaatgg taagctctgt   720
ggggatgttg attatgaggc ggttgcccca cttgctagcc acattacgcc agtccctgga   780
ggtgtcggtc ctatgaccat tactatgctg atggagcaaa cctatcaggc agcacttagg   840
acattggata gaaaa                                                    855

<210>   1576
<211>   285
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycloh
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902773 (e-160)

<400>   1576
Met Thr Gln Ile Ile Asp Gly Lys Ala Leu Ala Ala Lys Leu Gln Gly 
1               5                   10                  15      

Gln Leu Ala Glu Lys Thr Ala Lys Leu Lys Glu Glu Thr Gly Leu Val 
            20                  25                  30          

Pro Gly Leu Val Val Ile Leu Val Gly Asp Asn Pro Ala Ser Gln Val 
        35                  40                  45              

Tyr Val Arg Asn Lys Glu Arg Ser Ala Leu Ala Ala Gly Phe Arg Ser 
    50                  55                  60                  

Glu Val Val Arg Val Pro Glu Thr Ile Thr Gln Glu Glu Leu Leu Asp 
65                  70                  75                  80  

Leu Ile Ala Lys Tyr Asn Gln Asp Pro Ala Trp His Gly Ile Leu Val 
                85                  90                  95      

Gln Leu Pro Leu Pro Lys His Ile Asp Glu Glu Ala Val Leu Leu Ala 
            100                 105                 110         

Ile Asp Pro Glu Lys Asp Val Asp Gly Phe His Pro Leu Asn Met Gly 
        115                 120                 125             

Arg Leu Trp Ser Gly His Pro Val Met Ile Pro Ser Thr Pro Ala Gly 
    130                 135                 140                 

Ile Met Glu Met Phe His Glu Tyr Gly Ile Asp Leu Glu Gly Lys Asn 
145                 150                 155                 160 

Ala Val Val Ile Gly Arg Ser Asn Ile Val Gly Lys Pro Met Ala Gln 
                165                 170                 175     

Leu Leu Leu Ala Lys Asn Ala Thr Val Thr Leu Thr His Ser Arg Thr 
            180                 185                 190         

His Asn Leu Ser Lys Val Ala Ala Lys Ala Asp Ile Leu Val Val Ala 
        195                 200                 205             

Ile Gly Arg Ala Lys Phe Val Thr Ala Asp Phe Val Lys Pro Gly Ala 
    210                 215                 220                 

Val Val Ile Asp Val Gly Met Asn Arg Asp Glu Asn Gly Lys Leu Cys 
225                 230                 235                 240 

Gly Asp Val Asp Tyr Glu Ala Val Ala Pro Leu Ala Ser His Ile Thr 
                245                 250                 255     

Pro Val Pro Gly Gly Val Gly Pro Met Thr Ile Thr Met Leu Met Glu 
            260                 265                 270         

Gln Thr Tyr Gln Ala Ala Leu Arg Thr Leu Asp Arg Lys 
        275                 280                 285 

<210>   1577
<211>   819
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1577
atgattttaa aaatttataa tggggaatat agtttacaat gggatggaat atactactta   60
gcactaattg attatccaaa tattcaagag tgggaattag aaaaaattgc taaatttata   120
gcttacgaaa aacttcataa acgtcaaaca agtattgagt gtgctgattc ttgtttaaaa   180
aaagaaattt tagattacat ctgtcagcat ccctttctgc caccatttac tcctacagat   240
aaaagagtag cctcgactta tgacctacat aagaggttag tgacttcaga ctactgtagt   300
catactacga ctatagatgc agcgatttct atttttaaaa ctggtcgtct tttatctgct   360
gtgaaagcct ttgggcgaga tgctgaggag ttggttttgg atagtcgaaa tgctgcatct   420
gatccgatag attattttga ctatgtcatg ttagggtggt caaatacaag ttctggttat   480
cgattggcga tggagcgttt attaggtcga gctccttcag agaaagaatt acaagacaag   540
tttattcctg gagtaagttt tcattttatc tatacagatt tgattaaagt tcctggttat   600
atttttgatg gttaccatgc tgtaaaaatt aaggacatgc ttaatttatt aagtgagttg   660
tatatttgca ttattccaac tcataataag agccaatttg aaaatattat tccaaccaaa   720
atacaagata gggtgtatta tcttgactat gctggagaag acttagaaga gtggactaag   780
aaagtctatc aagttgtttt aaaacaatca gataaagga                          819

<210>   1578
<211>   273
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1578
Met Ile Leu Lys Ile Tyr Asn Gly Glu Tyr Ser Leu Gln Trp Asp Gly 
1               5                   10                  15      

Ile Tyr Tyr Leu Ala Leu Ile Asp Tyr Pro Asn Ile Gln Glu Trp Glu 
            20                  25                  30          

Leu Glu Lys Ile Ala Lys Phe Ile Ala Tyr Glu Lys Leu His Lys Arg 
        35                  40                  45              

Gln Thr Ser Ile Glu Cys Ala Asp Ser Cys Leu Lys Lys Glu Ile Leu 
    50                  55                  60                  

Asp Tyr Ile Cys Gln His Pro Phe Leu Pro Pro Phe Thr Pro Thr Asp 
65                  70                  75                  80  

Lys Arg Val Ala Ser Thr Tyr Asp Leu His Lys Arg Leu Val Thr Ser 
                85                  90                  95      

Asp Tyr Cys Ser His Thr Thr Thr Ile Asp Ala Ala Ile Ser Ile Phe 
            100                 105                 110         

Lys Thr Gly Arg Leu Leu Ser Ala Val Lys Ala Phe Gly Arg Asp Ala 
        115                 120                 125             

Glu Glu Leu Val Leu Asp Ser Arg Asn Ala Ala Ser Asp Pro Ile Asp 
    130                 135                 140                 

Tyr Phe Asp Tyr Val Met Leu Gly Trp Ser Asn Thr Ser Ser Gly Tyr 
145                 150                 155                 160 

Arg Leu Ala Met Glu Arg Leu Leu Gly Arg Ala Pro Ser Glu Lys Glu 
                165                 170                 175     

Leu Gln Asp Lys Phe Ile Pro Gly Val Ser Phe His Phe Ile Tyr Thr 
            180                 185                 190         

Asp Leu Ile Lys Val Pro Gly Tyr Ile Phe Asp Gly Tyr His Ala Val 
        195                 200                 205             

Lys Ile Lys Asp Met Leu Asn Leu Leu Ser Glu Leu Tyr Ile Cys Ile 
    210                 215                 220                 

Ile Pro Thr His Asn Lys Ser Gln Phe Glu Asn Ile Ile Pro Thr Lys 
225                 230                 235                 240 

Ile Gln Asp Arg Val Tyr Tyr Leu Asp Tyr Ala Gly Glu Asp Leu Glu 
                245                 250                 255     

Glu Trp Thr Lys Lys Val Tyr Gln Val Val Leu Lys Gln Ser Asp Lys 
            260                 265                 270         

Gly 
    

<210>   1579
<211>   837
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1579
atgaaagtga ttgatcaaac cttactagaa aaagtcatta ttgaacgttc ttgtacaagt   60
cataaaggag actacggtcg tctgctgttg cttggtggga cttatcctta tggtggtgcc   120
atcatcatgg ctgctttagc agctgtaaaa agcggtgcag gattggtaac cgttggaacg   180
gacagggaaa atatccctgc tctacacagc catttgcctg aggctatggc cttttctctg   240
caagatcagt aattgttaca agagcaattg gagaaggcag aagttgtctt gctggggcct   300
ggtttacgag acgatacgtt tggagaaaat cttgtaaaac aggtctttgc tagcttaaaa   360
aagaatcaga ttttgattgt agatggaggg gccttaacca tccttgctag gacaagtttg   420
ttgtttccat ctaaccagct tatcttaact ccccaccaaa aagaatggga aaaactgtct   480
ggtattgcta ttgaaaagca aaacgaaggt acaacatcta gtgccctgac ttctttccct   540
caaggaacaa ttttggtaga gaaaggtcca gctactcgta tttggcaagt tggccagtct   600
gattattacc agttaaaggt tggcggtccc tatcaggcga ctggtggtat gggtgataca   660
ctggctggaa tgattgcagg atttgcaggc caatttcgac aggccagtct ctacgaacgt   720
gtggcagtag caacccatct tcattcagcc atagcccaag aactatctca agaaaattat   780
gtggtcttgc cgacggaaat tagtaattgt cttcctaaag taatgaaaag atatgtc      837


<210>   1580
<400>   1580
000

<210>   1581
<211>   681
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1581
gtggaaaatc tgaagaaaat ggcaggtatc acggctgctg aatttatcaa ggatgggatg   60
gttgtagggc taggaacagg ttctactgcc tattattttg tcgaagaaat cggtcgtcga   120
atcaaggaag aaggcttgca gattacagct gtgacgactt ctagtgtgac cagtaaacag   180
gctgaagggc tcaatatccc gctcaagtct attgaccaag tagactttgt cgatgtgaca   240
gtcgacgggg cggatgaagt ggatagtcag tttaatggaa tcaaaggcgg tggtggtgcc   300
cttctcatgg aaaaggtggt cgcaacacca tcaaaagaat acatttgggt ggtggatgaa   360
agcaagctgg tcgaaaaact aggtgctttt aaattgccag tagaagtggt tcagtatggt   420
gcagagcagg tctttcgtca ttttgaacga gctggctaca aaccaagttt ccgtgaaaaa   480
gacggccaac gttttgtgac cgatatgcag aattttatca ttgacctcgc cttggatgtc   540
attgaaaatc caattgcttt tggacaagaa ttggaccatg tcgttggtgt tgtggagcat   600
ggtttattca accaaatggt ggataaggta atcgttgctg gacgagatgg agttcagatt   660
tcaacttcaa aaaaaggaaa a                                             681

<210>   1582
<211>   227
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribose 5-phosphate isomerase (rpiA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902775 (e-124)

<400>   1582
Met Glu Asn Leu Lys Lys Met Ala Gly Ile Thr Ala Ala Glu Phe Ile 
1               5                   10                  15      

Lys Asp Gly Met Val Val Gly Leu Gly Thr Gly Ser Thr Ala Tyr Tyr 
            20                  25                  30          

Phe Val Glu Glu Ile Gly Arg Arg Ile Lys Glu Glu Gly Leu Gln Ile 
        35                  40                  45              

Thr Ala Val Thr Thr Ser Ser Val Thr Ser Lys Gln Ala Glu Gly Leu 
    50                  55                  60                  

Asn Ile Pro Leu Lys Ser Ile Asp Gln Val Asp Phe Val Asp Val Thr 
65                  70                  75                  80  

Val Asp Gly Ala Asp Glu Val Asp Ser Gln Phe Asn Gly Ile Lys Gly 
                85                  90                  95      

Gly Gly Gly Ala Leu Leu Met Glu Lys Val Val Ala Thr Pro Ser Lys 
            100                 105                 110         

Glu Tyr Ile Trp Val Val Asp Glu Ser Lys Leu Val Glu Lys Leu Gly 
        115                 120                 125             

Ala Phe Lys Leu Pro Val Glu Val Val Gln Tyr Gly Ala Glu Gln Val 
    130                 135                 140                 

Phe Arg His Phe Glu Arg Ala Gly Tyr Lys Pro Ser Phe Arg Glu Lys 
145                 150                 155                 160 

Asp Gly Gln Arg Phe Val Thr Asp Met Gln Asn Phe Ile Ile Asp Leu 
                165                 170                 175     

Ala Leu Asp Val Ile Glu Asn Pro Ile Ala Phe Gly Gln Glu Leu Asp 
            180                 185                 190         

His Val Val Gly Val Val Glu His Gly Leu Phe Asn Gln Met Val Asp 
        195                 200                 205             

Lys Val Ile Val Ala Gly Arg Asp Gly Val Gln Ile Ser Thr Ser Lys 
    210                 215                 220                 

Lys Gly Lys 
225         

<210>   1583
<211>   1272
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1583
ttgctggacg agatggagtt cagatttcaa cttcaaaaaa aggaaaatag aagggggcat   60
aagatgtcta aatttaatcg tattcatttg gtggtactgg attctgtagg aatcggtgca   120
gcaccagatg ctaataactt tgtcaatgca ggggttccag atggagcttc tgacacactg   180
ggacacattt caaaaacagt tggtttgaat gtcccaaaca tggctaaaat aggtcttgga   240
aatattcctc gtgaaactcc tcttaagact gtagcagctg aaagcaatcc aactggatat   300
gcaacaaaat tagaggaagt atctcttggt aaggatacta tgactggaca ctgggaaatc   360
atgggactca acattactga gcctttcgat actttctgga acggattccc agaagaaatc   420
ctgacaaaaa tcgaagaatt ctcaggacgc aaggttattc gtgaagccaa caaaccttat   480
tcaggaacgg ctgttatcta tgattttgga ccacgtcaga tggaaactgg agagttgatt   540
atctatactt cagctgaccc tgttttgcag attgctgccc acgaagacat tattcctttg   600
gatgaattgt accgtatctg tgaatacgct cgttcgatta cccttgagcg tcctgccctt   660
cttggtcgca tcattgctcg cccttatgta ggtgaaccag gtaacttcac tcgtacggca   720
aaccgtcgtg acttggctgt atctccattt ttcccaactg ttttggataa attgaatgag   780
gctggtatcg atacttatgc tgtgggtaaa atcaacgata tctttaacgg tgctggtatc   840
aaccatgaca tgggtcacaa caagtcaaat agtcatggaa ttgatacact attgaagact   900
atgggacttg ctgagtttga aaaaggattc tcattcacaa acctagttga ctttgatgcc   960
ctttacggcc atcgtcgtaa tgctcacggt taccgtgatt gcttgcatga gtttgatgaa   1020
cgcttacctg aaattatcgc agctatgaga gagaatgacc ttctcttgat tactgcggac   1080
catggaaatg acccaacgta tgcaggaacg gatcacactc gggaatatat tccattgttg   1140
gcctatagcc ctgcctttaa aggaaatggt ctcattccag taggacattt tgcagatatt   1200
tcagcgactg ttgccgataa ctttggtgtg gaaactgcta tgattgggga aagtttctta   1260
gataaattgg ta                                                       1272

<210>   1584
<211>   424
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   phosphopentomutase (deoB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902776 (0.E+01)

<400>   1584
Met Leu Asp Glu Met Glu Phe Arg Phe Gln Leu Gln Lys Lys Glu Asn 
1               5                   10                  15      

Arg Arg Gly His Lys Met Ser Lys Phe Asn Arg Ile His Leu Val Val 
            20                  25                  30          

Leu Asp Ser Val Gly Ile Gly Ala Ala Pro Asp Ala Asn Asn Phe Val 
        35                  40                  45              

Asn Ala Gly Val Pro Asp Gly Ala Ser Asp Thr Leu Gly His Ile Ser 
    50                  55                  60                  

Lys Thr Val Gly Leu Asn Val Pro Asn Met Ala Lys Ile Gly Leu Gly 
65                  70                  75                  80  

Asn Ile Pro Arg Glu Thr Pro Leu Lys Thr Val Ala Ala Glu Ser Asn 
                85                  90                  95      

Pro Thr Gly Tyr Ala Thr Lys Leu Glu Glu Val Ser Leu Gly Lys Asp 
            100                 105                 110         

Thr Met Thr Gly His Trp Glu Ile Met Gly Leu Asn Ile Thr Glu Pro 
        115                 120                 125             

Phe Asp Thr Phe Trp Asn Gly Phe Pro Glu Glu Ile Leu Thr Lys Ile 
    130                 135                 140                 

Glu Glu Phe Ser Gly Arg Lys Val Ile Arg Glu Ala Asn Lys Pro Tyr 
145                 150                 155                 160 

Ser Gly Thr Ala Val Ile Tyr Asp Phe Gly Pro Arg Gln Met Glu Thr 
                165                 170                 175     

Gly Glu Leu Ile Ile Tyr Thr Ser Ala Asp Pro Val Leu Gln Ile Ala 
            180                 185                 190         

Ala His Glu Asp Ile Ile Pro Leu Asp Glu Leu Tyr Arg Ile Cys Glu 
        195                 200                 205             

Tyr Ala Arg Ser Ile Thr Leu Glu Arg Pro Ala Leu Leu Gly Arg Ile 
    210                 215                 220                 

Ile Ala Arg Pro Tyr Val Gly Glu Pro Gly Asn Phe Thr Arg Thr Ala 
225                 230                 235                 240 

Asn Arg Arg Asp Leu Ala Val Ser Pro Phe Phe Pro Thr Val Leu Asp 
                245                 250                 255     

Lys Leu Asn Glu Ala Gly Ile Asp Thr Tyr Ala Val Gly Lys Ile Asn 
            260                 265                 270         

Asp Ile Phe Asn Gly Ala Gly Ile Asn His Asp Met Gly His Asn Lys 
        275                 280                 285             

Ser Asn Ser His Gly Ile Asp Thr Leu Leu Lys Thr Met Gly Leu Ala 
    290                 295                 300                 

Glu Phe Glu Lys Gly Phe Ser Phe Thr Asn Leu Val Asp Phe Asp Ala 
305                 310                 315                 320 

Leu Tyr Gly His Arg Arg Asn Ala His Gly Tyr Arg Asp Cys Leu His 
                325                 330                 335     

Glu Phe Asp Glu Arg Leu Pro Glu Ile Ile Ala Ala Met Arg Glu Asn 
            340                 345                 350         

Asp Leu Leu Leu Ile Thr Ala Asp His Gly Asn Asp Pro Thr Tyr Ala 
        355                 360                 365             

Gly Thr Asp His Thr Arg Glu Tyr Ile Pro Leu Leu Ala Tyr Ser Pro 
    370                 375                 380                 

Ala Phe Lys Gly Asn Gly Leu Ile Pro Val Gly His Phe Ala Asp Ile 
385                 390                 395                 400 

Ser Ala Thr Val Ala Asp Asn Phe Gly Val Glu Thr Ala Met Ile Gly 
                405                 410                 415     

Glu Ser Phe Leu Asp Lys Leu Val 
            420                 

<210>   1585
<211>   540
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1585
atgacgcgct atgctttgct ggtgagaggt atcaatgttg gtggtaagaa taaggtcgtc   60
atggcggagc ttcgtcaaga attgacaaac ttgggactgg aaaaggttga gagctacatc   120

aatagtggca atattttctt tacttcgata gattccaaag cccaattggt tgaaaagcta   180
gagactttct ttgcagtcca ttatccattt attcagagct tttctttact gagtctagag   240
gactttgagg cggaacttga aaatctacca gcttggtgga gcagagactt ggcacgaaaa   300
gattttctct tttacactga gggtttggat gtggaccaag tcatcgcgac agttgaaagt   360
ttagagctga aagatgaagt gctttatttt ggaaaacttg ggattttctg ggggaaattt   420
tctgaagaat cctattctaa gactgcctat cataagtact tgctgaaggt gcctttctac   480
cgccacatta ctattcgtaa tgctaaaacc tttgacaaaa ttggtcaaat gctaaaaaaa   540

<210>   1586
<211>   180
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902777 (8.E-74)

<400>   1586
Met Thr Arg Tyr Ala Leu Leu Val Arg Gly Ile Asn Val Gly Gly Lys 
1               5                   10                  15      

Asn Lys Val Val Met Ala Glu Leu Arg Gln Glu Leu Thr Asn Leu Gly 
            20                  25                  30          

Leu Glu Lys Val Glu Ser Tyr Ile Asn Ser Gly Asn Ile Phe Phe Thr 
        35                  40                  45              

Ser Ile Asp Ser Lys Ala Gln Leu Val Glu Lys Leu Glu Thr Phe Phe 
    50                  55                  60                  

Ala Val His Tyr Pro Phe Ile Gln Ser Phe Ser Leu Leu Ser Leu Glu 
65                  70                  75                  80  

Asp Phe Glu Ala Glu Leu Glu Asn Leu Pro Ala Trp Trp Ser Arg Asp 
                85                  90                  95      

Leu Ala Arg Lys Asp Phe Leu Phe Tyr Thr Glu Gly Leu Asp Val Asp 
            100                 105                 110         

Gln Val Ile Ala Thr Val Glu Ser Leu Glu Leu Lys Asp Glu Val Leu 
        115                 120                 125             

Tyr Phe Gly Lys Leu Gly Ile Phe Trp Gly Lys Phe Ser Glu Glu Ser 
    130                 135                 140                 

Tyr Ser Lys Thr Ala Tyr His Lys Tyr Leu Leu Lys Val Pro Phe Tyr 
145                 150                 155                 160 

Arg His Ile Thr Ile Arg Asn Ala Lys Thr Phe Asp Lys Ile Gly Gln 

                165                 170                 175     

Met Leu Lys Lys 
            180 

<210>   1587
<211>   807
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1587
atgacatttt taaacaaaat ccatgaaact gctactttcc tgaaagaaaa gggaattgca   60
gcccctgagt tcggtctaat ccttggatca ggacttggag aattggcaga agaaatcgaa   120
aatccagttg tagtagacta tgctgagatt ccaaactggg gccgttcaac agtagtcggt   180
catgctggta aattggtata tggtgaactg gcaggtcgca aggtcttggc tcttcaaggg   240
cgtttccatt tctatgaagg gaatcctctg gaagtggtga ctttcccagt tcgtgtgatg   300
aaagttcttg gatgtgaagg tgttattgta accaatgcag ctggcggtat cggatttggt   360
cctggtacct tgatggctat ctcagaccat atcaacatga cggggcaaaa tccattgatg   420
ggtgaaaact tggatgactt tggcccacgt ttcccagata tgtctagggc ctacacacca   480
gaataccgtg ccactgccca tgaagtggct aaaaaactta atatcaagct tgatgaaggt   540
gtctatatcg gagttactgg tccgacttat gaaacaccag cagaaattcg ttcctataag   600
acactgggag cagatgcagt tggtatgtct acggttcctg aagttatcgt ggcagcccac   660
tctggcttga aagttctggg aatttcatgt atcactaact ttgcggccgg tttccaagaa   720
gaactcaatc acgaagaagt tgtagaagtg actgaacgtg ttaaaggtga tttcaaaggc   780
ttgcttaaag cgattcttgc tgaattg                                       807

<210>   1588
<211>   269
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   purine nucleoside phosphorylase, family 2 (deoD)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902778 (e-155)

<400>   1588
Met Thr Phe Leu Asn Lys Ile His Glu Thr Ala Thr Phe Leu Lys Glu 
1               5                   10                  15      

Lys Gly Ile Ala Ala Pro Glu Phe Gly Leu Ile Leu Gly Ser Gly Leu 
            20                  25                  30          

Gly Glu Leu Ala Glu Glu Ile Glu Asn Pro Val Val Val Asp Tyr Ala 
        35                  40                  45              

Glu Ile Pro Asn Trp Gly Arg Ser Thr Val Val Gly His Ala Gly Lys 
    50                  55                  60                  

Leu Val Tyr Gly Glu Leu Ala Gly Arg Lys Val Leu Ala Leu Gln Gly 
65                  70                  75                  80  

Arg Phe His Phe Tyr Glu Gly Asn Pro Leu Glu Val Val Thr Phe Pro 
                85                  90                  95      

Val Arg Val Met Lys Val Leu Gly Cys Glu Gly Val Ile Val Thr Asn 
            100                 105                 110         

Ala Ala Gly Gly Ile Gly Phe Gly Pro Gly Thr Leu Met Ala Ile Ser 
        115                 120                 125             

Asp His Ile Asn Met Thr Gly Gln Asn Pro Leu Met Gly Glu Asn Leu 
    130                 135                 140                 

Asp Asp Phe Gly Pro Arg Phe Pro Asp Met Ser Arg Ala Tyr Thr Pro 
145                 150                 155                 160 

Glu Tyr Arg Ala Thr Ala His Glu Val Ala Lys Lys Leu Asn Ile Lys 
                165                 170                 175     

Leu Asp Glu Gly Val Tyr Ile Gly Val Thr Gly Pro Thr Tyr Glu Thr 
            180                 185                 190         

Pro Ala Glu Ile Arg Ser Tyr Lys Thr Leu Gly Ala Asp Ala Val Gly 
        195                 200                 205             

Met Ser Thr Val Pro Glu Val Ile Val Ala Ala His Ser Gly Leu Lys 
    210                 215                 220                 

Val Leu Gly Ile Ser Cys Ile Thr Asn Phe Ala Ala Gly Phe Gln Glu 
225                 230                 235                 240 

Glu Leu Asn His Glu Glu Val Val Glu Val Thr Glu Arg Val Lys Gly 
                245                 250                 255     

Asp Phe Lys Gly Leu Leu Lys Ala Ile Leu Ala Glu Leu 
            260                 265                 

<210>   1589
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1589
gtggtaatag gtgtgctaga ttctaaggag gaattgaaag agtcagaaaa tgatgctcca   60
aaactagaaa ctcctcttag agaggagcca agactagctc ctcaaacgct tccggaagca   120
agtgaagttc ttgaaaacaa aagggaagag tcaaaagtag agataaca                168

<210>   1590
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902779 (7.E-27)

<400>   1590
Met Val Ile Gly Val Leu Asp Ser Lys Glu Glu Leu Lys Glu Ser Glu 
1               5                   10                  15      

Asn Asp Ala Pro Lys Leu Glu Thr Pro Leu Arg Glu Glu Pro Arg Leu 
            20                  25                  30          

Ala Pro Gln Thr Leu Pro Glu Ala Ser Glu Val Leu Glu Asn Lys Arg 
        35                  40                  45              

Glu Glu Ser Lys Val Glu Ile Thr 
    50                  55      

<210>   1591
<211>   753
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1591
ttgtatatga caggtcattc tcttggatgt tacctagctc agattgcagc ggttgaagct   60
taccaaaaat atcctgattt ttataaccat gtattgagga aagtgacaac tttcagtgct   120
cctaaagtga ttacttccag aactgtttgg aatgctaaga atggtttctg ggatgttggt   180
ttggaaagtc gtaaattagc tgttagtgga aaaattaagc attatgtggt tgataatgac   240
aatgttgtga ctcccttgat tcataataat cgtgatattg ttacatttac aggtaattca   300
cgctttaaac accgttctcg tggctatttt gaaagtccaa tgaatgatat tcctaacttt   360
aatattggta aacaagctac cttggataaa catggttatc gtgatccgaa attggataaa   420
gtgcgattct ttaagaaaca ggctctgcct cgatcttcta gtcaaccaag cgctgaacca   480
atggaaaata ttgcctcagg aaaacaggtt actcaaagtt cgacagcttt cggaggagat   540
gctagaagag ctgtggatgg caaagtcgat ggtaactatg gtcacaattc tgtcactcat   600
acaaacttcc aatctaagcc ttggtggcaa gtagatttgg ctaaagaaga aaccattcgc   660
caaatcaata tttacaaccg aacagacact gcccaggata gattggcaaa ctttgatgtc   720
attcttttag acagttctgg taaagaaatt gag                                753

<210>   1592
<211>   251
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902779 (2.E-95)

<400>   1592
Met Tyr Met Thr Gly His Ser Leu Gly Cys Tyr Leu Ala Gln Ile Ala 
1               5                   10                  15      

Ala Val Glu Ala Tyr Gln Lys Tyr Pro Asp Phe Tyr Asn His Val Leu 
            20                  25                  30          

Arg Lys Val Thr Thr Phe Ser Ala Pro Lys Val Ile Thr Ser Arg Thr 
        35                  40                  45              

Val Trp Asn Ala Lys Asn Gly Phe Trp Asp Val Gly Leu Glu Ser Arg 
    50                  55                  60                  

Lys Leu Ala Val Ser Gly Lys Ile Lys His Tyr Val Val Asp Asn Asp 
65                  70                  75                  80  

Asn Val Val Thr Pro Leu Ile His Asn Asn Arg Asp Ile Val Thr Phe 
                85                  90                  95      

Thr Gly Asn Ser Arg Phe Lys His Arg Ser Arg Gly Tyr Phe Glu Ser 
            100                 105                 110         

Pro Met Asn Asp Ile Pro Asn Phe Asn Ile Gly Lys Gln Ala Thr Leu 
        115                 120                 125             

Asp Lys His Gly Tyr Arg Asp Pro Lys Leu Asp Lys Val Arg Phe Phe 
    130                 135                 140                 

Lys Lys Gln Ala Leu Pro Arg Ser Ser Ser Gln Pro Ser Ala Glu Pro 
145                 150                 155                 160 

Met Glu Asn Ile Ala Ser Gly Lys Gln Val Thr Gln Ser Ser Thr Ala 
                165                 170                 175     

Phe Gly Gly Asp Ala Arg Arg Ala Val Asp Gly Lys Val Asp Gly Asn 
            180                 185                 190         

Tyr Gly His Asn Ser Val Thr His Thr Asn Phe Gln Ser Lys Pro Trp 
        195                 200                 205             

Trp Gln Val Asp Leu Ala Lys Glu Glu Thr Ile Arg Gln Ile Asn Ile 
    210                 215                 220                 

Tyr Asn Arg Thr Asp Thr Ala Gln Asp Arg Leu Ala Asn Phe Asp Val 
225                 230                 235                 240 

Ile Leu Leu Asp Ser Ser Gly Lys Glu Ile Glu 
                245                 250     

<210>   1593
<211>   510
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1593
gtgtcagcac aaattacgat taaccataaa aaagcgcgct atgttcggat tgagctagaa   60
ggctataatg ccctcagtct tgcagaagtt gaagttttct gctttatagc tacgaatgct   120
gaaacggcga cacaagtttc taagccagtt caaccaatca gtcagactcc tgtgaaggat   180
aaaacattga caattcaaca cagtggagct tacattgccc gctactccat aacttgggaa   240
gaagttccag tagataaaga tggaaaccaa gttgttcgta gtcattcttg ggaaggaagc   300
ggtcgcaacc agactgcagg ttttgtcctc aacctcccaa tcaaagaaaa tatgagaaat   360
ctgcgagtta agattgagaa aaagacgggc ctactatgga atagatggca aacaatctat   420
gaaaacagac caattttagc tcaaccccac cgtaaaatta cccattgggg tacgacattg   480
aattccaagg tgagtgacga tgatgtcttg                                    510

<210>   1594
<211>   170
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hemolysin-related protein
<223>   Cellular location: cytoplasm
<223>   Feature of note: secreted, similar to alveolysin, toxin
<223>   Similar to strain R6 sequence 15902781 (1.E-92)

<400>   1594
Met Ser Ala Gln Ile Thr Ile Asn His Lys Lys Ala Arg Tyr Val Arg 
1               5                   10                  15      

Ile Glu Leu Glu Gly Tyr Asn Ala Leu Ser Leu Ala Glu Val Glu Val 
            20                  25                  30          

Phe Cys Phe Ile Ala Thr Asn Ala Glu Thr Ala Thr Gln Val Ser Lys 
        35                  40                  45              

Pro Val Gln Pro Ile Ser Gln Thr Pro Val Lys Asp Lys Thr Leu Thr 
    50                  55                  60                  

Ile Gln His Ser Gly Ala Tyr Ile Ala Arg Tyr Ser Ile Thr Trp Glu 
65                  70                  75                  80  

Glu Val Pro Val Asp Lys Asp Gly Asn Gln Val Val Arg Ser His Ser 
                85                  90                  95      

Trp Glu Gly Ser Gly Arg Asn Gln Thr Ala Gly Phe Val Leu Asn Leu 
            100                 105                 110         

Pro Ile Lys Glu Asn Met Arg Asn Leu Arg Val Lys Ile Glu Lys Lys 
        115                 120                 125             

Thr Gly Leu Leu Trp Asn Arg Trp Gln Thr Ile Tyr Glu Asn Arg Pro 
    130                 135                 140                 

Ile Leu Ala Gln Pro His Arg Lys Ile Thr His Trp Gly Thr Thr Leu 
145                 150                 155                 160 

Asn Ser Lys Val Ser Asp Asp Asp Val Leu 
                165                 170 

<210>   1595
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1595
atgaaaatca aagagcaaac taagaaacta gccgcaggtt gctcaaagca ctgctttgag   60
gttgtagata agactgacga agtcagtcac atatataatc caaggcgacg t            111

<210>   1596
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1596
Met Lys Ile Lys Glu Gln Thr Lys Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Lys Thr Asp Glu Val Ser His Ile Tyr 
            20                  25                  30          

Asn Pro Arg Arg Arg 
        35          

<210>   1597
<211>   708
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1597
atgtctatcc atattgctgc tcagcagggt gaaattgctg ataaaattct tcttcctggg   60
gatcctcttc gtgctaagtt tattgcggag aatttccttg atgatgctgt ttgttttaac   120
gaagtgcgta acatgtttgg ttacactggt acttacaagg gtcactgtgt atctgtcatg   180
ggaactggga tgggaatgcc atctatttcg atttatgcgc gtgagttaat cgtagactac   240
ggtgtgaaga aattgattcg tgtgggaact gcaggttctt tgaatgaaga ggttcatgtt   300
cgtgaattag ttttggcgca ggcggctgca accaactcaa acatcgttcg taatgactgg   360
ccacagtacg attttccaca aattgctagc tttgatttgc ttgataaagc ctaccatatc   420
gccaaaaaac ttggtatgac tactcacgtt gggaacgttt tgtcatctga tgtcttttac   480
tcaaattact ttgaaaagaa tatcgagctt ggtaaatggg gagtcaaggc tgtggaaatg   540
gaagcagcag ctctttacta tcttgctgcc caataccatg ttgatgcgct agctatcatg   600
accatctctg atagcttggt caatccagac gaagacacaa ctgcagaaga acgtcaaaat   660
accttcactg atatgatgaa ggttggtttg gaaaccttga ttgcagaa                708

<210>   1598
<211>   236
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   purine nucleoside phosphorylase, family 1 (deoD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902782 (e-132)

<400>   1598
Met Ser Ile His Ile Ala Ala Gln Gln Gly Glu Ile Ala Asp Lys Ile 
1               5                   10                  15      

Leu Leu Pro Gly Asp Pro Leu Arg Ala Lys Phe Ile Ala Glu Asn Phe 
            20                  25                  30          

Leu Asp Asp Ala Val Cys Phe Asn Glu Val Arg Asn Met Phe Gly Tyr 
        35                  40                  45              

Thr Gly Thr Tyr Lys Gly His Cys Val Ser Val Met Gly Thr Gly Met 
    50                  55                  60                  

Gly Met Pro Ser Ile Ser Ile Tyr Ala Arg Glu Leu Ile Val Asp Tyr 
65                  70                  75                  80  

Gly Val Lys Lys Leu Ile Arg Val Gly Thr Ala Gly Ser Leu Asn Glu 
                85                  90                  95      

Glu Val His Val Arg Glu Leu Val Leu Ala Gln Ala Ala Ala Thr Asn 
            100                 105                 110         

Ser Asn Ile Val Arg Asn Asp Trp Pro Gln Tyr Asp Phe Pro Gln Ile 
        115                 120                 125             

Ala Ser Phe Asp Leu Leu Asp Lys Ala Tyr His Ile Ala Lys Lys Leu 
    130                 135                 140                 

Gly Met Thr Thr His Val Gly Asn Val Leu Ser Ser Asp Val Phe Tyr 
145                 150                 155                 160 

Ser Asn Tyr Phe Glu Lys Asn Ile Glu Leu Gly Lys Trp Gly Val Lys 
                165                 170                 175     

Ala Val Glu Met Glu Ala Ala Ala Leu Tyr Tyr Leu Ala Ala Gln Tyr 
            180                 185                 190         

His Val Asp Ala Leu Ala Ile Met Thr Ile Ser Asp Ser Leu Val Asn 
        195                 200                 205             

Pro Asp Glu Asp Thr Thr Ala Glu Glu Arg Gln Asn Thr Phe Thr Asp 
    210                 215                 220                 

Met Met Lys Val Gly Leu Glu Thr Leu Ile Ala Glu 
225                 230                 235     

<210>   1599
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1599
atggaacaat tacattttat cacaaaactg ctcgatatta aagacccaaa catcaagatt   60
ctagatatca tcaatatgga tacccacaaa gaaattatcg ctaagctgga ttatgaggct   120
ccatcttgcc ctgattgtgg aagtctaatg aagaaacatg actttcaaaa accgtctaag   180
atcccttacc tcgaaacaac tggtatgcct tctagaattc tccttagaaa acgccgtttc   240
aagtgctatc actcttcaaa aatgatggtt gctgagactc ccctggtaaa gaaaaatcac   300
caaatccctc gtatcatcaa ccaaaaaatt gctcaaaagt taattgaaaa aatttctatg   360
actgatattg cccatcagct ggccatttca acttcaactg tcattcgcaa gctcaatgac   420
tttcactttg agcatgattt ttctcggctt ccaaagatta tgtcttggga tgagtatgcc   480
ttcactaagg gaaagatgag tttcattgcg caagattttg ataatcttaa tattatcact   540
gttcttgaag gcagaacaca agctgtcatc cgaaatcact ttcttcgcta cgatagagcc   600
gttcgttgtc aagtgaaaat cattacgatg gatatgttta gtccttacta tgacttggct   660
aaacagcttt ttccgtgtgc taaaatcgtt ctagatcgtt tccatattat ccaacatctc   720
agccgtgcca tgagtcgttt tcgtgttcaa attatgaatc agtttgaacg aaaatctcat   780
gaatacaagg ctatcaagcg ttactggaaa ctcatccaac aggatagtcg taaattgagc   840
gataaacgtt tttatcgccc tacttttcgc atgcacttaa caaataaaga aattcttgac   900
aagattttaa gctattcaga agacttgaaa caccactatc agatctatca actcttactt   960
tttcactttc agaacaaaga ccctgagaaa tttttcggac tcattgagga caatctgaag   1020
caggttcatc ctctttttca gactgtcttt aaaacctttc taaagaacaa agagaaaatc   1080
gtcaacgccc ttcaactaca ctattctaat gccaaactgg aagcgaccaa taatctcatc   1140
aaacttatca agcgcaatgc ctttggtttt cggaactttg aaaacttcaa aaaacggatt   1200
tttatcgccc tgaatatcaa aaaagaaagg acgaaatttg tcctttctca agct         1254

<210>   1600
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903763 (0.E+01)

<400>   1600
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Lys Ile Leu Asp Ile Ile Asn Met Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Glu Ala Pro Ser Cys Pro Asp Cys Gly Ser 
        35                  40                  45              

Leu Met Lys Lys His Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Ser Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Ser Ser Lys Met Met Val Ala Glu Thr Pro Leu Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ala 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Glu 
    130                 135                 140                 

His Asp Phe Ser Arg Leu Pro Lys Ile Met Ser Trp Asp Glu Tyr Ala 
145                 150                 155                 160 

Phe Thr Lys Gly Lys Met Ser Phe Ile Ala Gln Asp Phe Asp Asn Leu 
                165                 170                 175     

Asn Ile Ile Thr Val Leu Glu Gly Arg Thr Gln Ala Val Ile Arg Asn 
            180                 185                 190         

His Phe Leu Arg Tyr Asp Arg Ala Val Arg Cys Gln Val Lys Ile Ile 
        195                 200                 205             

Thr Met Asp Met Phe Ser Pro Tyr Tyr Asp Leu Ala Lys Gln Leu Phe 
    210                 215                 220                 

Pro Cys Ala Lys Ile Val Leu Asp Arg Phe His Ile Ile Gln His Leu 
225                 230                 235                 240 

Ser Arg Ala Met Ser Arg Phe Arg Val Gln Ile Met Asn Gln Phe Glu 
                245                 250                 255     

Arg Lys Ser His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile 
            260                 265                 270         

Gln Gln Asp Ser Arg Lys Leu Ser Asp Lys Arg Phe Tyr Arg Pro Thr 
        275                 280                 285             

Phe Arg Met His Leu Thr Asn Lys Glu Ile Leu Asp Lys Ile Leu Ser 
    290                 295                 300                 

Tyr Ser Glu Asp Leu Lys His His Tyr Gln Ile Tyr Gln Leu Leu Leu 
305                 310                 315                 320 

Phe His Phe Gln Asn Lys Asp Pro Glu Lys Phe Phe Gly Leu Ile Glu 
                325                 330                 335     

Asp Asn Leu Lys Gln Val His Pro Leu Phe Gln Thr Val Phe Lys Thr 
            340                 345                 350         

Phe Leu Lys Asn Lys Glu Lys Ile Val Asn Ala Leu Gln Leu His Tyr 
        355                 360                 365             

Ser Asn Ala Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys 
    370                 375                 380                 

Arg Asn Ala Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile 
385                 390                 395                 400 

Phe Ile Ala Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser 
                405                 410                 415     

Gln Ala 
        

<210>   1601
<211>   522
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1601
atgaaaatcg caattatcgg atattctggt tctggtaagt caactatagc agaaaagtta   60
tctaactact actccattcc aaaactgcac atggacacac tccaatttca acctggttgg   120
caagacagtg actgcgaatg gatgttaacc gagataaaaa actttctcac caagcataaa   180
gcttgggtca tcgatggtaa ttattcttgg tgctactacc aagaacgaat gcaagaagct   240
gaccaaatca tctttctcaa tttttcgcca ttgacctgtc tctttagagc ctttaagcgt   300
tatcttaaat accgtggaaa agtcagagaa agtatggcgg tagattgccc tgaacgcttt   360
gagtgggagt ttatcagatg gattctttgg gatgggcgta gcaaaactca aaaagaaaat   420
taccaaaaac tttgccaaga atattcacat aaagtcacta ttcttcgaaa tcagagagag   480
ctagatcaat ttctggataa gaaaaggaag tcctacaatt ca                      522

<210>   1602
<211>   174
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA topology modulation protein FlaR, putative, FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902783 (e-103)

<400>   1602
Met Lys Ile Ala Ile Ile Gly Tyr Ser Gly Ser Gly Lys Ser Thr Ile 
1               5                   10                  15      

Ala Glu Lys Leu Ser Asn Tyr Tyr Ser Ile Pro Lys Leu His Met Asp 
            20                  25                  30          

Thr Leu Gln Phe Gln Pro Gly Trp Gln Asp Ser Asp Cys Glu Trp Met 
        35                  40                  45              

Leu Thr Glu Ile Lys Asn Phe Leu Thr Lys His Lys Ala Trp Val Ile 
    50                  55                  60                  

Asp Gly Asn Tyr Ser Trp Cys Tyr Tyr Gln Glu Arg Met Gln Glu Ala 
65                  70                  75                  80  

Asp Gln Ile Ile Phe Leu Asn Phe Ser Pro Leu Thr Cys Leu Phe Arg 
                85                  90                  95      

Ala Phe Lys Arg Tyr Leu Lys Tyr Arg Gly Lys Val Arg Glu Ser Met 
            100                 105                 110         

Ala Val Asp Cys Pro Glu Arg Phe Glu Trp Glu Phe Ile Arg Trp Ile 
        115                 120                 125             

Leu Trp Asp Gly Arg Ser Lys Thr Gln Lys Glu Asn Tyr Gln Lys Leu 
    130                 135                 140                 

Cys Gln Glu Tyr Ser His Lys Val Thr Ile Leu Arg Asn Gln Arg Glu 
145                 150                 155                 160 

Leu Asp Gln Phe Leu Asp Lys Lys Arg Lys Ser Tyr Asn Ser 
                165                 170                 

<210>   1603
<211>   234
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1603
ttggcaaaca ttaaatcagc tatcaaacgc gctgaattga acgttaaaca aaacgaaaag   60
aactcagctc aaaaatcagc tatgcgtact gctataaaag ctttcgaagc aaacccatct   120
gaagaacttt tccgtgctgc tagctcagct atcgataaag cagaaactaa aggtttgatt   180
cacaaaaaca aagcaagccg cgataaagct cgtctttcag ctaaacttgt taaa         234

<210>   1604
<211>   78
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S20 (rpsT)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902784 (4.E-37)

<400>   1604
Met Ala Asn Ile Lys Ser Ala Ile Lys Arg Ala Glu Leu Asn Val Lys 
1               5                   10                  15      

Gln Asn Glu Lys Asn Ser Ala Gln Lys Ser Ala Met Arg Thr Ala Ile 
            20                  25                  30          

Lys Ala Phe Glu Ala Asn Pro Ser Glu Glu Leu Phe Arg Ala Ala Ser 
        35                  40                  45              

Ser Ala Ile Asp Lys Ala Glu Thr Lys Gly Leu Ile His Lys Asn Lys 
    50                  55                  60                  

Ala Ser Arg Asp Lys Ala Arg Leu Ser Ala Lys Leu Val Lys 
65                  70                  75              

<210>   1605
<211>   948
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1605
atgatagaca aaatatctag gggaaaacaa atgaccaacg aatttttaca ttttgaaaaa   60
atcagccgcc agacttggca atctttacat cgaaagacaa cacctccttt gacagaagaa   120
gaattggaat ctatcaagag ttttaatgac caaatcagtc tccaagacgt tacagatatc   180
tatctcccct tggctcattt gattcagatt tacaagcgaa ctaaggaaga tttagccttt   240
tcaaaaggaa ttttcctcca acgtgaaagt aaatctcaac cttttattat tggggtttct   300
gggagtgttg ccgttggaaa atccacaacc agtcgcctac ttcaaatcct actgtcccgt   360
acgtttacag atgctacggt tgagttggtt acaactgatg gttttctcta tcccaatcaa   420
accttgattg agcaggggat tttaaatcgt aaaggatttc ctgaaagcta tgatatggaa   480
gctcttctca acttcttgga ccgcatcaaa aatggacaag atgtagatat tcctgtctat   540
tctcatgaag tttacgacat cgtacccgaa gagaaacaaa gtgtcaaagc tgctgatttt   600
gtaattgttg agggaatcaa tgtctttcaa aatccacaaa acgatcgtct ctatatcact   660
gacttctttg acttttccat ctatgtagat gctggagtgg atgatattga aagttggtat   720
ctggaccgtt tcttgaaaat gctgagtcta gcccaaaacg accctgatag ctactattat   780
cgttttactc agatgccgat tggggaagtg gagtcctttg cccatcaggt ctggatcagt   840
atcaatctca caaatctgca aaattatatt gaaccaacca gaaatcgtgc agaagtgatt   900
cttcataaaa gcaagaacca tgaaatcgat gaaatttact taaaaaag                948

<210>   1606
<211>   316
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pantothenate kinase (coaA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902785 (e-176)

<400>   1606
Met Ile Asp Lys Ile Ser Arg Gly Lys Gln Met Thr Asn Glu Phe Leu 
1               5                   10                  15      

His Phe Glu Lys Ile Ser Arg Gln Thr Trp Gln Ser Leu His Arg Lys 
            20                  25                  30          

Thr Thr Pro Pro Leu Thr Glu Glu Glu Leu Glu Ser Ile Lys Ser Phe 
        35                  40                  45              

Asn Asp Gln Ile Ser Leu Gln Asp Val Thr Asp Ile Tyr Leu Pro Leu 
    50                  55                  60                  

Ala His Leu Ile Gln Ile Tyr Lys Arg Thr Lys Glu Asp Leu Ala Phe 
65                  70                  75                  80  

Ser Lys Gly Ile Phe Leu Gln Arg Glu Ser Lys Ser Gln Pro Phe Ile 
                85                  90                  95      

Ile Gly Val Ser Gly Ser Val Ala Val Gly Lys Ser Thr Thr Ser Arg 
            100                 105                 110         

Leu Leu Gln Ile Leu Leu Ser Arg Thr Phe Thr Asp Ala Thr Val Glu 
        115                 120                 125             

Leu Val Thr Thr Asp Gly Phe Leu Tyr Pro Asn Gln Thr Leu Ile Glu 
    130                 135                 140                 

Gln Gly Ile Leu Asn Arg Lys Gly Phe Pro Glu Ser Tyr Asp Met Glu 
145                 150                 155                 160 

Ala Leu Leu Asn Phe Leu Asp Arg Ile Lys Asn Gly Gln Asp Val Asp 
                165                 170                 175     

Ile Pro Val Tyr Ser His Glu Val Tyr Asp Ile Val Pro Glu Glu Lys 
            180                 185                 190         

Gln Ser Val Lys Ala Ala Asp Phe Val Ile Val Glu Gly Ile Asn Val 
        195                 200                 205             

Phe Gln Asn Pro Gln Asn Asp Arg Leu Tyr Ile Thr Asp Phe Phe Asp 
    210                 215                 220                 

Phe Ser Ile Tyr Val Asp Ala Gly Val Asp Asp Ile Glu Ser Trp Tyr 
225                 230                 235                 240 

Leu Asp Arg Phe Leu Lys Met Leu Ser Leu Ala Gln Asn Asp Pro Asp 
                245                 250                 255     

Ser Tyr Tyr Tyr Arg Phe Thr Gln Met Pro Ile Gly Glu Val Glu Ser 
            260                 265                 270         

Phe Ala His Gln Val Trp Ile Ser Ile Asn Leu Thr Asn Leu Gln Asn 
        275                 280                 285             

Tyr Ile Glu Pro Thr Arg Asn Arg Ala Glu Val Ile Leu His Lys Ser 
    290                 295                 300                 

Lys Asn His Glu Ile Asp Glu Ile Tyr Leu Lys Lys 
305                 310                 315     

<210>   1607
<211>   234
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1607
atgaaaatct taaaacgtta catattggaa ctctgtttta ttttaagttt tgctttacct   60
tttataaaag gaaccaatgc agataatggt agatgctttg tggaaaccta ttacggtttt   120
acttttttga tggaacatgc tattgtaaca gctgtcttta tttgttcgtt cttaattgct   180
ttcttactaa aaaacgatgg acgaaatgga ttgctgcggg tagttattgc tttt         234

<210>   1608
<211>   78
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902786 (2.E-31)

<400>   1608
Met Lys Ile Leu Lys Arg Tyr Ile Leu Glu Leu Cys Phe Ile Leu Ser 
1               5                   10                  15      

Phe Ala Leu Pro Phe Ile Lys Gly Thr Asn Ala Asp Asn Gly Arg Cys 
            20                  25                  30          

Phe Val Glu Thr Tyr Tyr Gly Phe Thr Phe Leu Met Glu His Ala Ile 
        35                  40                  45              

Val Thr Ala Val Phe Ile Cys Ser Phe Leu Ile Ala Phe Leu Leu Lys 
    50                  55                  60                  

Asn Asp Gly Arg Asn Gly Leu Leu Arg Val Val Ile Ala Phe 
65                  70                  75              

<210>   1609
<211>   588
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1609
atgagtaaaa tgtactatgc agaaaatcct gacgctgctc acgacattca tgagttgaga   60
gtggacttgt tgggagaaaa aatgactttt ttgacagatg cgggtgtttt tagcaagaaa   120
atggttgact ttggaagtca actcttgctc aagtgtctgg atgtcaacca aggagagaca   180
gtcctagatg taggctgtgg ttatggtcca ttaggtttgt ccttggtcaa ggtttacgga   240
gttcaggcga ccatggttga tattaacact cgtgccctgg atttagctca gagaaatgct   300
gaaaaaaata atgcaaaagc gacgatattt caatctaata tttatgcaag agttcaaggg   360
cgatttgacc atgtcatttc caatcctcct atccgtgcgg gcaagcaagt cgttcatgaa   420
atcatcgaga aaagtaaaga tttcttggaa attggtggag atttgaccat cgtcatccag   480
aaaaaacaag gagctccaag tgccaagtct aagatggaag atgtgtttgg caattgtgaa   540
atccttaaaa aagacaaggg atactatatc cttagaagtg tgaaagaa                588

<210>   1610
<211>   196
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902787 (e-104)

<400>   1610
Met Ser Lys Met Tyr Tyr Ala Glu Asn Pro Asp Ala Ala His Asp Ile 
1               5                   10                  15      

His Glu Leu Arg Val Asp Leu Leu Gly Glu Lys Met Thr Phe Leu Thr 
            20                  25                  30          

Asp Ala Gly Val Phe Ser Lys Lys Met Val Asp Phe Gly Ser Gln Leu 
        35                  40                  45              

Leu Leu Lys Cys Leu Asp Val Asn Gln Gly Glu Thr Val Leu Asp Val 
    50                  55                  60                  

Gly Cys Gly Tyr Gly Pro Leu Gly Leu Ser Leu Val Lys Val Tyr Gly 
65                  70                  75                  80  

Val Gln Ala Thr Met Val Asp Ile Asn Thr Arg Ala Leu Asp Leu Ala 
                85                  90                  95      

Gln Arg Asn Ala Glu Lys Asn Asn Ala Lys Ala Thr Ile Phe Gln Ser 
            100                 105                 110         

Asn Ile Tyr Ala Arg Val Gln Gly Arg Phe Asp His Val Ile Ser Asn 
        115                 120                 125             

Pro Pro Ile Arg Ala Gly Lys Gln Val Val His Glu Ile Ile Glu Lys 
    130                 135                 140                 

Ser Lys Asp Phe Leu Glu Ile Gly Gly Asp Leu Thr Ile Val Ile Gln 
145                 150                 155                 160 


Lys Lys Gln Gly Ala Pro Ser Ala Lys Ser Lys Met Glu Asp Val Phe 
                165                 170                 175     

Gly Asn Cys Glu Ile Leu Lys Lys Asp Lys Gly Tyr Tyr Ile Leu Arg 
            180                 185                 190         

Ser Val Lys Glu 
        195     

<210>   1611
<211>   1275
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1611
atgagagcag ttgatttaat ccaaaaaaaa cgagacggtc aagaactgac ttcaagtgaa   60
attgaatggc tgatagaagg ctatgtatca ggaactgttc ctgattatca gatgtctgcc   120
tttgctatgg ctgtttattt taaaggaatg acgactcgag aaatctctga tttaacgatg   180
aatatggtta agactgggca agagtttgac ctgtcagcca ttgatggtgt gaaagttgac   240
aagcattcta ctggtggtgt cggcgataag gtaaccttga ttttagctcc tcttgttgct   300
agcttcggtg tgcctgtagc aaaaatgagt ggtcgtggtc ttggccatac aggcggaaca   360
attgataaat tggagtccat taagggctat caagtagaac gtagtcaaga ggattttatt   420
cgtcaggttc aggatattgg agtatctgtc attgggcaat cagaccagct ggtcaaagca   480
gataagcttc tctatgccct tcgtgatgtg accgcaactg tcgacacgat tcctttgatt   540
gcgagttcgg tgatgagcaa gaaaattgcg gcaggggcgg atgctatttt gctagacgtg   600
actgtcggtg agggtgcctt catgaagacg gttgatgagg cgcgtgagtt ggctcaaact   660
atggtagatc ttggtaaggt tgttggacgg aagacagtag cagtgattac ggatatgagc   720
cagcctttgg gacgagcgat tggaaatcgt ctggaaatcc ttgaagcatt ggagattttg   780
caaggtcaag gacgtcagga tattacccac tttatttgtg aattggctca aattatgctt   840
ggtttggcaa atgttaacaa aactgttgaa gaagttcacc aacatcttga gaatggtcaa   900
gcactggcta agtttgagga aatggtgcaa gcccaaggtg gagacttgga agacctctat   960
cgtcctgtaa atgtagctca tgtggtggaa atccctgctc aggaaacggg tgtcatttca   1020
gctcttccag ctatggactt tggtctttat gccatgaggc tgggtgctgg tcgtgcagtt   1080
aagtctgatg ccttggacta tgaaacagga attgtttttg aaaagaagat tggagactcc   1140
gttcaaaagg gtgaaattgt tgcaaaagta tacacaaatg aaaaaattcc acctcaacta   1200
gttacagatt tccaaaaatg tgttaaaata agtgatgaag tgaaaaaaat ccgtgaaatt   1260
gtagaaatca tctcc                                                    1275

<210>   1612
<211>   425
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyrimidine-nucleoside phosphorylase (pyn)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902788 (0.E+01)

<400>   1612
Met Arg Ala Val Asp Leu Ile Gln Lys Lys Arg Asp Gly Gln Glu Leu 
1               5                   10                  15      

Thr Ser Ser Glu Ile Glu Trp Leu Ile Glu Gly Tyr Val Ser Gly Thr 
            20                  25                  30          

Val Pro Asp Tyr Gln Met Ser Ala Phe Ala Met Ala Val Tyr Phe Lys 
        35                  40                  45              

Gly Met Thr Thr Arg Glu Ile Ser Asp Leu Thr Met Asn Met Val Lys 
    50                  55                  60                  

Thr Gly Gln Glu Phe Asp Leu Ser Ala Ile Asp Gly Val Lys Val Asp 
65                  70                  75                  80  

Lys His Ser Thr Gly Gly Val Gly Asp Lys Val Thr Leu Ile Leu Ala 
                85                  90                  95      

Pro Leu Val Ala Ser Phe Gly Val Pro Val Ala Lys Met Ser Gly Arg 
            100                 105                 110         

Gly Leu Gly His Thr Gly Gly Thr Ile Asp Lys Leu Glu Ser Ile Lys 
        115                 120                 125             

Gly Tyr Gln Val Glu Arg Ser Gln Glu Asp Phe Ile Arg Gln Val Gln 
    130                 135                 140                 

Asp Ile Gly Val Ser Val Ile Gly Gln Ser Asp Gln Leu Val Lys Ala 
145                 150                 155                 160 

Asp Lys Leu Leu Tyr Ala Leu Arg Asp Val Thr Ala Thr Val Asp Thr 
                165                 170                 175     

Ile Pro Leu Ile Ala Ser Ser Val Met Ser Lys Lys Ile Ala Ala Gly 
            180                 185                 190         

Ala Asp Ala Ile Leu Leu Asp Val Thr Val Gly Glu Gly Ala Phe Met 
        195                 200                 205             

Lys Thr Val Asp Glu Ala Arg Glu Leu Ala Gln Thr Met Val Asp Leu 
    210                 215                 220                 

Gly Lys Val Val Gly Arg Lys Thr Val Ala Val Ile Thr Asp Met Ser 
225                 230                 235                 240 

Gln Pro Leu Gly Arg Ala Ile Gly Asn Arg Leu Glu Ile Leu Glu Ala 
                245                 250                 255     

Leu Glu Ile Leu Gln Gly Gln Gly Arg Gln Asp Ile Thr His Phe Ile 
            260                 265                 270         

Cys Glu Leu Ala Gln Ile Met Leu Gly Leu Ala Asn Val Asn Lys Thr 
        275                 280                 285             

Val Glu Glu Val His Gln His Leu Glu Asn Gly Gln Ala Leu Ala Lys 
    290                 295                 300                 

Phe Glu Glu Met Val Gln Ala Gln Gly Gly Asp Leu Glu Asp Leu Tyr 
305                 310                 315                 320 

Arg Pro Val Asn Val Ala His Val Val Glu Ile Pro Ala Gln Glu Thr 
                325                 330                 335     

Gly Val Ile Ser Ala Leu Pro Ala Met Asp Phe Gly Leu Tyr Ala Met 
            340                 345                 350         

Arg Leu Gly Ala Gly Arg Ala Val Lys Ser Asp Ala Leu Asp Tyr Glu 
        355                 360                 365             

Thr Gly Ile Val Phe Glu Lys Lys Ile Gly Asp Ser Val Gln Lys Gly 
    370                 375                 380                 


Glu Ile Val Ala Lys Val Tyr Thr Asn Glu Lys Ile Pro Pro Gln Leu 
385                 390                 395                 400 

Val Thr Asp Phe Gln Lys Cys Val Lys Ile Ser Asp Glu Val Lys Lys 
                405                 410                 415     

Ile Arg Glu Ile Val Glu Ile Ile Ser 
            420                 425 

<210>   1613
<211>   660
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1613
atgaaattaa ataaatatat agatcatacg cttttaaaac aagatgcaaa gaaaaaacaa   60
attgatagtt tgttgtctga ggctagagag tatgactttg ccagtgtttg cgttaatccg   120
acctgggttg aacatgctaa aaaaggactt gaaggcacag atgttaaggt ttgcacagta   180
gtaggtttcc ctttgggagc aacaacttca gccgtgaaag catttgagac aaaagaagct   240
atccaaaatg gtgcagatga gattgatatg gtgatcaatg ttggagctct caaatcaggt   300
aatttagcct tggttgagtc agatattcgc gcagtagtgg aagcaagtgg tgataagtta   360
gtgaaagtca ttattgaagc ttgccttctg acagaccaag aaaaagttgt tgtttgccaa   420
ttggcccaaa aagctggggc tgactttgtc aaaacatcta ctggcttttc aactggtggt   480
gctacgatag cagatgttac attaatgcgt gaaacagttg gatctgatat gggtgtcaag   540
gccgccggtg gagctcgttc ttatgcagat gctcttgcct ttgtcgaagc aggtgcgacc   600
cgtatcggaa cgtcagctgg ggtagctatt ttaaaaggag aattggcaga tggcgactac   660

<210>   1614
<211>   220
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   deoxyribose-phosphate aldolase (deoC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902789 (e-120)

<400>   1614
Met Lys Leu Asn Lys Tyr Ile Asp His Thr Leu Leu Lys Gln Asp Ala 
1               5                   10                  15      

Lys Lys Lys Gln Ile Asp Ser Leu Leu Ser Glu Ala Arg Glu Tyr Asp 
            20                  25                  30          

Phe Ala Ser Val Cys Val Asn Pro Thr Trp Val Glu His Ala Lys Lys 
        35                  40                  45              

Gly Leu Glu Gly Thr Asp Val Lys Val Cys Thr Val Val Gly Phe Pro 
    50                  55                  60                  

Leu Gly Ala Thr Thr Ser Ala Val Lys Ala Phe Glu Thr Lys Glu Ala 
65                  70                  75                  80  

Ile Gln Asn Gly Ala Asp Glu Ile Asp Met Val Ile Asn Val Gly Ala 
                85                  90                  95      

Leu Lys Ser Gly Asn Leu Ala Leu Val Glu Ser Asp Ile Arg Ala Val 
            100                 105                 110         

Val Glu Ala Ser Gly Asp Lys Leu Val Lys Val Ile Ile Glu Ala Cys 
        115                 120                 125             

Leu Leu Thr Asp Gln Glu Lys Val Val Val Cys Gln Leu Ala Gln Lys 
    130                 135                 140                 

Ala Gly Ala Asp Phe Val Lys Thr Ser Thr Gly Phe Ser Thr Gly Gly 
145                 150                 155                 160 

Ala Thr Ile Ala Asp Val Thr Leu Met Arg Glu Thr Val Gly Ser Asp 
                165                 170                 175     

Met Gly Val Lys Ala Ala Gly Gly Ala Arg Ser Tyr Ala Asp Ala Leu 
            180                 185                 190         

Ala Phe Val Glu Ala Gly Ala Thr Arg Ile Gly Thr Ser Ala Gly Val 
        195                 200                 205             

Ala Ile Leu Lys Gly Glu Leu Ala Asp Gly Asp Tyr 
    210                 215                 220 

<210>   1615
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1615
atggcgacta ctgagttgat tgaactggca attgaaacca gcaaacatgc ctatgtcccc   60
tattctcact ttcctatcgg agcagtttta gtagctaaag acggaagtgt ttacacggga   120
gtgaatattg aaaatgctag ctatcctttg accaattgcg gtgagagaac agctattttt   180
aaggctatat ctgaaggcca aagagaattt tcagaattga ttgtctatgg tcaaactgaa   240
aaaccgatct cgccatgtgg tgcttgtcgc caagtgatgg ctgaattttt tgaacaagat   300
ctaaaagtga ccttagtcgc aaaagataaa tcgacggtcg agatgacggt cggggaatta   360
cttccatact cttttacaga cttaaac                                       387

<210>   1616
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cytidine deaminase (cdd)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902790 (6.E-71)

<400>   1616
Met Ala Thr Thr Glu Leu Ile Glu Leu Ala Ile Glu Thr Ser Lys His 
1               5                   10                  15      

Ala Tyr Val Pro Tyr Ser His Phe Pro Ile Gly Ala Val Leu Val Ala 
            20                  25                  30          

Lys Asp Gly Ser Val Tyr Thr Gly Val Asn Ile Glu Asn Ala Ser Tyr 
        35                  40                  45              

Pro Leu Thr Asn Cys Gly Glu Arg Thr Ala Ile Phe Lys Ala Ile Ser 
    50                  55                  60                  

Glu Gly Gln Arg Glu Phe Ser Glu Leu Ile Val Tyr Gly Gln Thr Glu 
65                  70                  75                  80  

Lys Pro Ile Ser Pro Cys Gly Ala Cys Arg Gln Val Met Ala Glu Phe 
                85                  90                  95      

Phe Glu Gln Asp Leu Lys Val Thr Leu Val Ala Lys Asp Lys Ser Thr 
            100                 105                 110         

Val Glu Met Thr Val Gly Glu Leu Leu Pro Tyr Ser Phe Thr Asp Leu 
        115                 120                 125             

Asn 
    

<210>   1617
<211>   1050
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1617
atgaacaaga aacaatggct aggtcttggc ctagttgcag tggcagcagt tggacttgct   60
gcatgtggta accgctcttc tcgtaacgca gcttcatctt ctgatgtgaa gacaaaagca   120
gcaatcgtca ctgatactgg tggtgttgat gacaaatcat tcaaccaatc agcttgggaa   180
ggtttgcagg cttggggtaa agaacacaat ctttcaaaag ataacggttt cacttacttc   240
caatcaacaa gtgaagctga ctacgctaac aacttgcaac aagcggctgg aagttacaac   300
ctaatcttcg gtgttggttt tgcccttaat aatgcagtta aagatgcagc aaaagaacac   360
actgacttga actatgtctt gattgatgat gtgattaaag accaaaagaa tgttgcgagc   420
gtaactttcg ctgataatga gtcaggttac cttgcaggtg tggctgcagc aaaaacaact   480
aagacaaaac aagttggttt tgtaggtggt atcgaatctg aagttatctc tcgttttgaa   540
gcaggattca aggctggtgt tgcgtcagta gacccatcta tcaaagtcca agttgactac   600
gctggttcat ttggtgatgc ggctaaaggt aaaacaattg cagccgcaca atacgcagcc   660
ggtgcagata ttgtttacca agtagctggt ggtacaggtg caggtgtctt tgcagaggca   720
aaatctctca acgaaagccg tcctgaaaat gaaaaagttt gggttatcgg tgttgatcgt   780
gaccaagaag cagaaggtaa atacacttct aaagatggca aagaatcaaa ctttgttctt   840
gtatctactt tgaaacaagt tggtacaact gtaaaagata tttctaacaa ggcagaaaga   900
ggagaattcc ctggcggtca agtgatcgtt tactcattga aggataaagg ggttgacttg   960
gcagtaacaa acctttcaga agaaggtaaa aaagctgtcg aagatgcaaa agctaaaatc   1020
cttgatggaa gcgtaaaagt tcctgaaaaa                                    1050

<210>   1618
<211>   350
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lipoprotein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902791 (0.E+01)

<400>   1618
Met Asn Lys Lys Gln Trp Leu Gly Leu Gly Leu Val Ala Val Ala Ala 
1               5                   10                  15      

Val Gly Leu Ala Ala Cys Gly Asn Arg Ser Ser Arg Asn Ala Ala Ser 
            20                  25                  30          

Ser Ser Asp Val Lys Thr Lys Ala Ala Ile Val Thr Asp Thr Gly Gly 
        35                  40                  45              

Val Asp Asp Lys Ser Phe Asn Gln Ser Ala Trp Glu Gly Leu Gln Ala 
    50                  55                  60                  

Trp Gly Lys Glu His Asn Leu Ser Lys Asp Asn Gly Phe Thr Tyr Phe 
65                  70                  75                  80  

Gln Ser Thr Ser Glu Ala Asp Tyr Ala Asn Asn Leu Gln Gln Ala Ala 
                85                  90                  95      

Gly Ser Tyr Asn Leu Ile Phe Gly Val Gly Phe Ala Leu Asn Asn Ala 
            100                 105                 110         

Val Lys Asp Ala Ala Lys Glu His Thr Asp Leu Asn Tyr Val Leu Ile 
        115                 120                 125             

Asp Asp Val Ile Lys Asp Gln Lys Asn Val Ala Ser Val Thr Phe Ala 
    130                 135                 140                 

Asp Asn Glu Ser Gly Tyr Leu Ala Gly Val Ala Ala Ala Lys Thr Thr 
145                 150                 155                 160 

Lys Thr Lys Gln Val Gly Phe Val Gly Gly Ile Glu Ser Glu Val Ile 
                165                 170                 175     

Ser Arg Phe Glu Ala Gly Phe Lys Ala Gly Val Ala Ser Val Asp Pro 
            180                 185                 190         

Ser Ile Lys Val Gln Val Asp Tyr Ala Gly Ser Phe Gly Asp Ala Ala 
        195                 200                 205             

Lys Gly Lys Thr Ile Ala Ala Ala Gln Tyr Ala Ala Gly Ala Asp Ile 
    210                 215                 220                 

Val Tyr Gln Val Ala Gly Gly Thr Gly Ala Gly Val Phe Ala Glu Ala 
225                 230                 235                 240 

Lys Ser Leu Asn Glu Ser Arg Pro Glu Asn Glu Lys Val Trp Val Ile 
                245                 250                 255     

Gly Val Asp Arg Asp Gln Glu Ala Glu Gly Lys Tyr Thr Ser Lys Asp 
            260                 265                 270         

Gly Lys Glu Ser Asn Phe Val Leu Val Ser Thr Leu Lys Gln Val Gly 
        275                 280                 285             

Thr Thr Val Lys Asp Ile Ser Asn Lys Ala Glu Arg Gly Glu Phe Pro 
    290                 295                 300                 

Gly Gly Gln Val Ile Val Tyr Ser Leu Lys Asp Lys Gly Val Asp Leu 
305                 310                 315                 320 

Ala Val Thr Asn Leu Ser Glu Glu Gly Lys Lys Ala Val Glu Asp Ala 
                325                 330                 335     

Lys Ala Lys Ile Leu Asp Gly Ser Val Lys Val Pro Glu Lys 
            340                 345                 350 

<210>   1619
<211>   1533
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1619
atggcacacg aaaatgtcat tgagatgcgt gatattacca aggtgtttgg tggatttgtt   60
gccaacgaca aaatcaactt gcacctacga aaaggtgaaa ttcatgcact tttaggagaa   120
aatggggctg gtaagtccac gctaatgaac atgttagcag gccttcttga accaactagt   180
ggtgaaatcg cggtcaacgg tcaagttgtc aatctcgact ccccatctaa agcagctagc   240
ttgggaatcg ggatggttca ccagcacttt atgttggttg aagccttcac agtggctgaa   300
aacatcattt taggtagtga attgactaaa aatggtgtgc tagatatcgc tggagctagc   360
aaagaaatca aggctctttc tgaacgttat ggcttagctg ttgacccttc tgccaaggta   420
gcagatatct cagttggagc ccaacaacgt gtagaaattt taaaaacact ttatcggggg   480
gctgatatcc ttatctttga cgaaccaacg gctgttttga ctccatcaga aattgatgag   540
ttgatggcta ttatgaaaaa tcttgtcaaa gaaggaaaat caattatctt gattacccac   600
aaattggatg aaattcgagc agtttctgac cgtgttacag ttatccgtcg tgggaaatca   660
attgaaaccg ttgaaattgc aggggctacc aatgctgatt tggcggaaat gatggtagga   720
cgttctgttt cctttaaaac agagaagcaa gcctctaaac caaaagaagt ggttttgtct   780
atcaaagatt tggtggtcaa tgaaaaccgt ggtgttccag ctgttaaaaa tctgtccttg   840
gatgttcgtg ctggagagat tgttggtatt gcggggattg atggaaatgg tcagtctgaa   900
ctgattcaag ccattacagg tcttcgtaag gttgaatctg gtagcattga gctaaaagga   960
gattcaattg taggcttgca cccacgtcag attacagaac taagtgttgg gcacgttcca   1020
gaagaccgtc accgtgatgg cttgattttg gaaatgatga tatctgaaaa tattgccctt   1080
caaacctact ataaagaacc acatagtaaa aatggaattt tgaattattc aaatattact   1140
tcttatgcta aaaagctgat ggaagagttt gatgttcgcg ctgccagtga attagttcct   1200
gcagctgcac tctcaggagg aaatcaacaa aaagcaatta ttgctcgtga aattgatcga   1260
gatcctgatc tccttatcgt tagccagcca actcgtgggt tggatgtcgg tgccattgag   1320
tatatccaca aacgcttgat tgaagagcgt gataatggca aggctgtcct tgttgtcagc   1380
tttgaattgg atgagatttt aaacgtctca gaccgtattg ccgttatcca cgatggtaag   1440
attcaaggta ttgtatcacc agaaacaacc aataaacaag aacttggtgt cttgatggct   1500
ggtggaaact tgggaaagga gaagagtgat gtc                                1533

<210>   1620
<211>   511
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902792 (0.E+01)

<400>   1620
Met Ala His Glu Asn Val Ile Glu Met Arg Asp Ile Thr Lys Val Phe 
1               5                   10                  15      

Gly Gly Phe Val Ala Asn Asp Lys Ile Asn Leu His Leu Arg Lys Gly 
            20                  25                  30          

Glu Ile His Ala Leu Leu Gly Glu Asn Gly Ala Gly Lys Ser Thr Leu 
        35                  40                  45              

Met Asn Met Leu Ala Gly Leu Leu Glu Pro Thr Ser Gly Glu Ile Ala 
    50                  55                  60                  

Val Asn Gly Gln Val Val Asn Leu Asp Ser Pro Ser Lys Ala Ala Ser 
65                  70                  75                  80  

Leu Gly Ile Gly Met Val His Gln His Phe Met Leu Val Glu Ala Phe 
                85                  90                  95      

Thr Val Ala Glu Asn Ile Ile Leu Gly Ser Glu Leu Thr Lys Asn Gly 
            100                 105                 110         

Val Leu Asp Ile Ala Gly Ala Ser Lys Glu Ile Lys Ala Leu Ser Glu 
        115                 120                 125             

Arg Tyr Gly Leu Ala Val Asp Pro Ser Ala Lys Val Ala Asp Ile Ser 
    130                 135                 140                 

Val Gly Ala Gln Gln Arg Val Glu Ile Leu Lys Thr Leu Tyr Arg Gly 
145                 150                 155                 160 

Ala Asp Ile Leu Ile Phe Asp Glu Pro Thr Ala Val Leu Thr Pro Ser 
                165                 170                 175     

Glu Ile Asp Glu Leu Met Ala Ile Met Lys Asn Leu Val Lys Glu Gly 
            180                 185                 190         

Lys Ser Ile Ile Leu Ile Thr His Lys Leu Asp Glu Ile Arg Ala Val 
        195                 200                 205             

Ser Asp Arg Val Thr Val Ile Arg Arg Gly Lys Ser Ile Glu Thr Val 
    210                 215                 220                 

Glu Ile Ala Gly Ala Thr Asn Ala Asp Leu Ala Glu Met Met Val Gly 
225                 230                 235                 240 

Arg Ser Val Ser Phe Lys Thr Glu Lys Gln Ala Ser Lys Pro Lys Glu 
                245                 250                 255     

Val Val Leu Ser Ile Lys Asp Leu Val Val Asn Glu Asn Arg Gly Val 
            260                 265                 270         

Pro Ala Val Lys Asn Leu Ser Leu Asp Val Arg Ala Gly Glu Ile Val 
        275                 280                 285             

Gly Ile Ala Gly Ile Asp Gly Asn Gly Gln Ser Glu Leu Ile Gln Ala 
    290                 295                 300                 

Ile Thr Gly Leu Arg Lys Val Glu Ser Gly Ser Ile Glu Leu Lys Gly 
305                 310                 315                 320 

Asp Ser Ile Val Gly Leu His Pro Arg Gln Ile Thr Glu Leu Ser Val 
                325                 330                 335     

Gly His Val Pro Glu Asp Arg His Arg Asp Gly Leu Ile Leu Glu Met 
            340                 345                 350         

Met Ile Ser Glu Asn Ile Ala Leu Gln Thr Tyr Tyr Lys Glu Pro His 
        355                 360                 365             

Ser Lys Asn Gly Ile Leu Asn Tyr Ser Asn Ile Thr Ser Tyr Ala Lys 
    370                 375                 380                 

Lys Leu Met Glu Glu Phe Asp Val Arg Ala Ala Ser Glu Leu Val Pro 
385                 390                 395                 400 

Ala Ala Ala Leu Ser Gly Gly Asn Gln Gln Lys Ala Ile Ile Ala Arg 
                405                 410                 415     

Glu Ile Asp Arg Asp Pro Asp Leu Leu Ile Val Ser Gln Pro Thr Arg 
            420                 425                 430         

Gly Leu Asp Val Gly Ala Ile Glu Tyr Ile His Lys Arg Leu Ile Glu 
        435                 440                 445             

Glu Arg Asp Asn Gly Lys Ala Val Leu Val Val Ser Phe Glu Leu Asp 
    450                 455                 460                 

Glu Ile Leu Asn Val Ser Asp Arg Ile Ala Val Ile His Asp Gly Lys 

465                 470                 475                 480 

Ile Gln Gly Ile Val Ser Pro Glu Thr Thr Asn Lys Gln Glu Leu Gly 
                485                 490                 495     

Val Leu Met Ala Gly Gly Asn Leu Gly Lys Glu Lys Ser Asp Val 
            500                 505                 510     

<210>   1621
<211>   1056
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1621
atgtctaaaa aattacaaca aatttcggtt cccttgattt ctgtattcct aggaatttta   60
ctcggagcca ttgtcatgtg gatcttcggt tatgatgcta tttggggcta cgaagaattg   120
ttctatacag cctttggcag tctgcgtggg attggagaaa tcttccgtgc tatgggtcct   180
ctggtcttga ttggtcttgg ttttgccgtt gccagtcgag ctggtttctt taacgtcgga   240
cttcctggtc aggctttggc aggttggatt ctcagtggtt ggtttgccct gtcgcatcca   300
gatatgcccc gtcccttgat gattctagca accatcgtga ttgccttgat tgctggtggg   360
attgtcggag cgattccagg tattcttagg gcctatctag ggacgtcaga ggttattgta   420
accatcatga tgaactacat tgtcttgtat gtagggaatg cctttatcca tgctttccct   480
aaagacttca tgcaaagtac agattcgacc attcgtgttg gggctaatgc aacctatcag   540
acaccttggt tggctgagtt gactggtaac tcacggatga atattggtat tttctttgcc   600
atcattgccg ttgcagttat ttggttcatg ctcaagaaaa caactcttgg ttttgaaatc   660
cgtgcagttg gtcttaatcc acatgcttca gaatatgctg gtatttctgc caagcggact   720
attatcctat ctatgattat ttcaggtgcc ttggcaggtc ttggtggagc tgttgaaggt   780
ttgggaacct tccagaacgt ctatgttcaa ggttcgtcat tagctatcgg atttaacgga   840
atggcggtta gtttgcttgc ggccaactca ccaattggta tactctttgc agccttccta   900
tttggcgttc tccaagttgg ggctcctggt atgaatgcgg cgcaggtacc atctgagctt   960
gtcagcattg taacagcgtc tattatcttc tttgtcagtg ttcattacct tatcgaacgc   1020
tttgtcaaac cgaaaaaaca agttaaagga ggtaag                             1056

<210>   1622
<211>   352
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, permease protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902793 (0.E+01)

<400>   1622
Met Ser Lys Lys Leu Gln Gln Ile Ser Val Pro Leu Ile Ser Val Phe 
1               5                   10                  15      

Leu Gly Ile Leu Leu Gly Ala Ile Val Met Trp Ile Phe Gly Tyr Asp 
            20                  25                  30          

Ala Ile Trp Gly Tyr Glu Glu Leu Phe Tyr Thr Ala Phe Gly Ser Leu 
        35                  40                  45              

Arg Gly Ile Gly Glu Ile Phe Arg Ala Met Gly Pro Leu Val Leu Ile 
    50                  55                  60                  

Gly Leu Gly Phe Ala Val Ala Ser Arg Ala Gly Phe Phe Asn Val Gly 
65                  70                  75                  80  

Leu Pro Gly Gln Ala Leu Ala Gly Trp Ile Leu Ser Gly Trp Phe Ala 
                85                  90                  95      

Leu Ser His Pro Asp Met Pro Arg Pro Leu Met Ile Leu Ala Thr Ile 
            100                 105                 110         

Val Ile Ala Leu Ile Ala Gly Gly Ile Val Gly Ala Ile Pro Gly Ile 
        115                 120                 125             

Leu Arg Ala Tyr Leu Gly Thr Ser Glu Val Ile Val Thr Ile Met Met 
    130                 135                 140                 

Asn Tyr Ile Val Leu Tyr Val Gly Asn Ala Phe Ile His Ala Phe Pro 
145                 150                 155                 160 

Lys Asp Phe Met Gln Ser Thr Asp Ser Thr Ile Arg Val Gly Ala Asn 
                165                 170                 175     

Ala Thr Tyr Gln Thr Pro Trp Leu Ala Glu Leu Thr Gly Asn Ser Arg 
            180                 185                 190         

Met Asn Ile Gly Ile Phe Phe Ala Ile Ile Ala Val Ala Val Ile Trp 
        195                 200                 205             

Phe Met Leu Lys Lys Thr Thr Leu Gly Phe Glu Ile Arg Ala Val Gly 
    210                 215                 220                 

Leu Asn Pro His Ala Ser Glu Tyr Ala Gly Ile Ser Ala Lys Arg Thr 
225                 230                 235                 240 

Ile Ile Leu Ser Met Ile Ile Ser Gly Ala Leu Ala Gly Leu Gly Gly 
                245                 250                 255     

Ala Val Glu Gly Leu Gly Thr Phe Gln Asn Val Tyr Val Gln Gly Ser 
            260                 265                 270         

Ser Leu Ala Ile Gly Phe Asn Gly Met Ala Val Ser Leu Leu Ala Ala 
        275                 280                 285             

Asn Ser Pro Ile Gly Ile Leu Phe Ala Ala Phe Leu Phe Gly Val Leu 
    290                 295                 300                 

Gln Val Gly Ala Pro Gly Met Asn Ala Ala Gln Val Pro Ser Glu Leu 
305                 310                 315                 320 

Val Ser Ile Val Thr Ala Ser Ile Ile Phe Phe Val Ser Val His Tyr 
                325                 330                 335     

Leu Ile Glu Arg Phe Val Lys Pro Lys Lys Gln Val Lys Gly Gly Lys 
            340                 345                 350         


<210>   1623
<211>   954
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1623
atgtctatta taaccttgct ccccctcttg gtgtcttcta tgctgattta ctcagcacct   60
ctcatcttta caagtatcgg tggtgttttc tctgaacgtg gtggtgtggt aaacgttggc   120
cttgaaggaa ttatggttat gggtgccttt tctggagttg tctttaacct tgaatttgca   180
gaacaatttg gagcagcaac tccatggcta tccttgcttg tagcaggatt ggttggtagt   240
gttttctcta tcatccacgc agcagcgacg gttcatttcc gtgcagacca tgttgtcagc   300
ggtacggtat tgaacttgat ggcgcctgcc ttggctgttt tcttagttaa agttctttat   360
aacaaaggac aaaccgacaa cctaagtcaa acttttggac gctttgattt cccagtcttg   420
gcaaatatcc cagtgattgg tgatatcttc ttcaagtcaa ctagtctact tggttatctg   480
gcgattgcct tctcattcct tgcttggttt attctcttta agactcaatt tggtcttcgt   540
ctccgctctg tcggtgaaca tcctcaagca gcggatacct tgggaatcaa cgtctacaag   600
atgagatatt taggggttat tatttcaggt tttctaggtg gaattggcgg agcgatttat   660
gcgcaatcaa tctcagttaa cttctcagtg acaactattg ttggacctgg atttatcgcc   720
cttgctgcga tgatctttgg gaaatggaat ccaatcggtg ctatgctttc tagtctcttc   780
tttggacttt cacaaagttt ggctgttatc ggttctcaat tgccgttcct acaaggagtg   840
ccagcggttt atcttcaaat tgcaccttat gttttgacaa ttcttgtctt agcagccttc   900
tttggaaaag cagtcgcacc aaaagcagat ggtatcaact acatcaaatc aaaa         954

<210>   1624
<211>   318
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, permease protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902794 (e-177)

<400>   1624
Met Ser Ile Ile Thr Leu Leu Pro Leu Leu Val Ser Ser Met Leu Ile 
1               5                   10                  15      

Tyr Ser Ala Pro Leu Ile Phe Thr Ser Ile Gly Gly Val Phe Ser Glu 
            20                  25                  30          

Arg Gly Gly Val Val Asn Val Gly Leu Glu Gly Ile Met Val Met Gly 
        35                  40                  45              

Ala Phe Ser Gly Val Val Phe Asn Leu Glu Phe Ala Glu Gln Phe Gly 
    50                  55                  60                  

Ala Ala Thr Pro Trp Leu Ser Leu Leu Val Ala Gly Leu Val Gly Ser 
65                  70                  75                  80  

Val Phe Ser Ile Ile His Ala Ala Ala Thr Val His Phe Arg Ala Asp 
                85                  90                  95      

His Val Val Ser Gly Thr Val Leu Asn Leu Met Ala Pro Ala Leu Ala 
            100                 105                 110         

Val Phe Leu Val Lys Val Leu Tyr Asn Lys Gly Gln Thr Asp Asn Leu 
        115                 120                 125             

Ser Gln Thr Phe Gly Arg Phe Asp Phe Pro Val Leu Ala Asn Ile Pro 
    130                 135                 140                 

Val Ile Gly Asp Ile Phe Phe Lys Ser Thr Ser Leu Leu Gly Tyr Leu 
145                 150                 155                 160 

Ala Ile Ala Phe Ser Phe Leu Ala Trp Phe Ile Leu Phe Lys Thr Gln 
                165                 170                 175     

Phe Gly Leu Arg Leu Arg Ser Val Gly Glu His Pro Gln Ala Ala Asp 
            180                 185                 190         

Thr Leu Gly Ile Asn Val Tyr Lys Met Arg Tyr Leu Gly Val Ile Ile 
        195                 200                 205             

Ser Gly Phe Leu Gly Gly Ile Gly Gly Ala Ile Tyr Ala Gln Ser Ile 
    210                 215                 220                 

Ser Val Asn Phe Ser Val Thr Thr Ile Val Gly Pro Gly Phe Ile Ala 
225                 230                 235                 240 

Leu Ala Ala Met Ile Phe Gly Lys Trp Asn Pro Ile Gly Ala Met Leu 
                245                 250                 255     

Ser Ser Leu Phe Phe Gly Leu Ser Gln Ser Leu Ala Val Ile Gly Ser 
            260                 265                 270         

Gln Leu Pro Phe Leu Gln Gly Val Pro Ala Val Tyr Leu Gln Ile Ala 
        275                 280                 285             

Pro Tyr Val Leu Thr Ile Leu Val Leu Ala Ala Phe Phe Gly Lys Ala 
    290                 295                 300                 

Val Ala Pro Lys Ala Asp Gly Ile Asn Tyr Ile Lys Ser Lys 
305                 310                 315             

<210>   1625
<211>   436
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1625
atgaaattaa gttatgatga taaagttcag atctatgaac ttagaaaaca aggatatagc   60
ttagagaagc tttcaaataa atttgggata aacaattcta atcttaggta tatgattaaa   120
ttgattgatc gttacggaat agagttcgtc aaaaaaggaa aaaatcgtta ctattctcct   180
gatttaaaac aagaaatgat taataaagtc tgacatgaag gctggactaa agatagagtt   240
tctcttgaat acggtctccc aagtcgtacg atacttctta actggctagc acaatacagg   300
aaaaacgggt atactattgt tgagaaacca agagggagag tacctgagag cggagaatgc   360
catcctaaaa aagttaagag aactccgatt gaaggaggaa aaagagaaag aagaaagaca   420
gaaattgttt aagaat                                                   436

<210>   1626
<211>   70
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, hypothetical protein POINT MUTATION FRAMESHIFT

<400>   1626
Met Lys Leu Ser Tyr Asp Asp Lys Val Gln Ile Tyr Glu Leu Arg Lys 
1               5                   10                  15      

Gln Gly Tyr Ser Leu Glu Lys Leu Ser Asn Lys Phe Gly Ile Asn Asn 
            20                  25                  30          

Ser Asn Leu Arg Tyr Met Ile Lys Leu Ile Asp Arg Tyr Gly Ile Glu 
        35                  40                  45              

Phe Val Lys Lys Gly Lys Asn Arg Tyr Tyr Ser Pro Asp Leu Lys Gln 
    50                  55                  60                  

Glu Met Ile Asn Lys Val 
65                  70  

<210>   1627
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1627
ttgttgagaa accaagaggg agagtacctg agagcggaga atgccatcct aaaaaagtta   60
agagaactcc gattgaagga ggaaaaagag aaagaagaaa gacagaaatt gtttaagaat   120

<210>   1628
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1628
Met Leu Arg Asn Gln Glu Gly Glu Tyr Leu Arg Ala Glu Asn Ala Ile 
1               5                   10                  15      

Leu Lys Lys Leu Arg Glu Leu Arg Leu Lys Glu Glu Lys Glu Lys Glu 
            20                  25                  30          

Glu Arg Gln Lys Leu Phe Lys Asn 
        35                  40  

<210>   1629
<211>   831
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1629
atgactgagt tttcgttaga tcttctttta aaagtcatta aactagctcg ttcgacctac   60
tactatcact tgaaacagct agataaacca gataaggacc aagagcttaa agctgaaatt   120
caatccattt ttatcgaaca caaaggaaat tatgcttatc gtcggattta tttagaacta   180
agaaatcgtg gttatctggt aaatcataaa agagttcaag gcttgatgaa agtactcaat   240
ttacaagcta aaacgcgaca gaaacgaaaa tattcttctc ataaaggaga cgttggcaag   300
aaggcagaga atctcattca aggccaattt gaaggctcta aaacaatgga acagtgctac   360
acagatgtga cagaatttgc cattccagta agtacttaaa agctttactt atcaccagtt   420
ttagatggct ttaatagcga aattatcgcc tataatcttt caacttcacc caacttagaa   480
caagtacaaa caatgttgga acaggcattc acagagaagc actacgagaa tacgattctc   540
catagtgacc aaggctggca ataccaacac gattcttatc atcggttcct agagagtaag   600
ggaattcaag catccatgtc acgtaagggc aacagccaag acaacggtag gatggaatct   660
ttctttggca ttttaaaatc cgaaatgttt tatggctatg agaaaacatt taaatcactt   720
aatcaattgg aacaagccat tatagactat attgattact acaacaacaa acgaattaag   780
gtaaaactaa aaggacttag tcctgtgcag tacagaacta aatcctttgg a            831

<210>   1630
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, transposase POINT MUTATION

<400>   1630
Met Thr Glu Phe Ser Leu Asp Leu Leu Leu Lys Val Ile Lys Leu Ala 
1               5                   10                  15      

Arg Ser Thr Tyr Tyr Tyr His Leu Lys Gln Leu Asp Lys Pro Asp Lys 
            20                  25                  30          

Asp Gln Glu Leu Lys Ala Glu Ile Gln Ser Ile Phe Ile Glu His Lys 
        35                  40                  45              

Gly Asn Tyr Ala Tyr Arg Arg Ile Tyr Leu Glu Leu Arg Asn Arg Gly 
    50                  55                  60                  

Tyr Leu Val Asn His Lys Arg Val Gln Gly Leu Met Lys Val Leu Asn 
65                  70                  75                  80  

Leu Gln Ala Lys Thr Arg Gln Lys Arg Lys Tyr Ser Ser His Lys Gly 
                85                  90                  95      

Asp Val Gly Lys Lys Ala Glu Asn Leu Ile Gln Gly Gln Phe Glu Gly 
            100                 105                 110         

Ser Lys Thr Met Glu Gln Cys Tyr Thr Asp Val Thr Glu Phe Ala Ile 
        115                 120                 125             

Pro Val Ser Thr 
    130         

<210>   1631
<211>   339
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1631
atgttggaac aggcattcac agagaagcac tacgagaata cgattctcca tagtgaccaa   60
ggctggcaat accaacacga ttcttatcat cggttcctag agagtaaggg aattcaagca   120
tccatgtcac gtaagggcaa cagccaagac aacggtagga tggaatcttt ctttggcatt   180
ttaaaatccg aaatgtttta tggctatgag aaaacattta aatcacttaa tcaattggaa   240
caagccatta tagactatat tgattactac aacaacaaac gaattaaggt aaaactaaaa   300
ggacttagtc ctgtgcagta cagaactaaa tcctttgga                          339

<210>   1632
<211>   113
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA transposase

<400>   1632
Met Leu Glu Gln Ala Phe Thr Glu Lys His Tyr Glu Asn Thr Ile Leu 
1               5                   10                  15      

His Ser Asp Gln Gly Trp Gln Tyr Gln His Asp Ser Tyr His Arg Phe 
            20                  25                  30          

Leu Glu Ser Lys Gly Ile Gln Ala Ser Met Ser Arg Lys Gly Asn Ser 
        35                  40                  45              

Gln Asp Asn Gly Arg Met Glu Ser Phe Phe Gly Ile Leu Lys Ser Glu 
    50                  55                  60                  

Met Phe Tyr Gly Tyr Glu Lys Thr Phe Lys Ser Leu Asn Gln Leu Glu 
65                  70                  75                  80  

Gln Ala Ile Ile Asp Tyr Ile Asp Tyr Tyr Asn Asn Lys Arg Ile Lys 
                85                  90                  95      

Val Lys Leu Lys Gly Leu Ser Pro Val Gln Tyr Arg Thr Lys Ser Phe 
            100                 105                 110         

Gly 
    

<210>   1633
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   1633
atgattacaa tagttttatt aatcctagcc tatctgctgg gttcgattcc atctggtctc   60
tggattggac aagtattctt tcaaatcaat ctacgcgagc atggttctgg taacactgga   120
acgaccaaca ccttccgcat tttaggtaag aaagctggta tggcaacctt tgtgattgac   180
tttttcaaag gaaccctagc aacgctgctt ccgattattt ttcatctaca aggcgtttct   240
cctctcatct ttggactttt ggctgttatc ggccatacct tccctatctt tgcaggattt   300
aaaggtggta aggctgtcgc aaccagtgct ggagtgattt tcggatttgc gcctatcttc   360
tgtctctacc ttgcgattat cttctttgga gctctctatc ttggcagtat gatttcactg   420
tctagtgtca cagcatcgat tgcggctgtt atcggggttc tgctctttcc actttttggt   480
tttatcctga gtaactatga ctctctcttc atcgctatta tcttagcact tgctagtttg   540
attatcattc gtcataagga caatatagct cgtatcaaaa ataaaactga aaatttggtc   600
ccttggggat tgaacctaac ccatcaagat cctaaaaaa                          639

<210>   1634
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902799 (e-118)

<400>   1634
Met Ile Thr Ile Val Leu Leu Ile Leu Ala Tyr Leu Leu Gly Ser Ile 
1               5                   10                  15      

Pro Ser Gly Leu Trp Ile Gly Gln Val Phe Phe Gln Ile Asn Leu Arg 
            20                  25                  30          

Glu His Gly Ser Gly Asn Thr Gly Thr Thr Asn Thr Phe Arg Ile Leu 
        35                  40                  45              

Gly Lys Lys Ala Gly Met Ala Thr Phe Val Ile Asp Phe Phe Lys Gly 
    50                  55                  60                  

Thr Leu Ala Thr Leu Leu Pro Ile Ile Phe His Leu Gln Gly Val Ser 
65                  70                  75                  80  

Pro Leu Ile Phe Gly Leu Leu Ala Val Ile Gly His Thr Phe Pro Ile 
                85                  90                  95      

Phe Ala Gly Phe Lys Gly Gly Lys Ala Val Ala Thr Ser Ala Gly Val 
            100                 105                 110         

Ile Phe Gly Phe Ala Pro Ile Phe Cys Leu Tyr Leu Ala Ile Ile Phe 
        115                 120                 125             

Phe Gly Ala Leu Tyr Leu Gly Ser Met Ile Ser Leu Ser Ser Val Thr 
    130                 135                 140                 

Ala Ser Ile Ala Ala Val Ile Gly Val Leu Leu Phe Pro Leu Phe Gly 
145                 150                 155                 160 

Phe Ile Leu Ser Asn Tyr Asp Ser Leu Phe Ile Ala Ile Ile Leu Ala 
                165                 170                 175     

Leu Ala Ser Leu Ile Ile Ile Arg His Lys Asp Asn Ile Ala Arg Ile 
            180                 185                 190         

Lys Asn Lys Thr Glu Asn Leu Val Pro Trp Gly Leu Asn Leu Thr His 
        195                 200                 205             

Gln Asp Pro Lys Lys 
    210             

<210>   1635
<211>   1941
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1635
gtgtcaaaaa aggaaatcaa tattaacaat tataatgatg atgctattca ggtgctagaa   60
gggttggatg cggtccgaaa acgtccaggg atgtatattg gatcgaccga tggcgctggt   120
cttcatcacc tagtttggga aatcgttgat aatgcagtcg atgaagcctt gtctgggttt   180
ggtgatcgta ttgatgtaac tatcaataaa gacggtagtc taacggttca agaccatgga   240
cgtgggatgc cgacaggtat gcacgctatg ggaattccaa ctgttgaggt tatctttacc   300
attcttcatg ccggagggaa attcggtcaa ggtggctata agacatcagg tggacttcac   360
ggagtgggtt cttccgttgt taacgccctt tctagctggt tagaagttga aattacccgt   420
gatggcgcag tttacaagca acgtttcgaa aatggtggaa aacctgtcac gactttgaag   480
aaaatcggta cagcacccaa gtctaaaaca ggcaccaaag ttacttttat gcctgacgcg   540
actatatttt ctacgacaga tttcaagtac aataccattt cagagcgcct taatgaatca   600
gcctttctct tgaaaaatgt gaccttgtct ttaacggaca agcgaacaaa tgaagcgatt   660
gagttccact atgagaatgg agtacaagat tttgtttctt atctcaacga agataaggaa   720
atcttgacgc cagttcttta ctttgaaggg gaagacaatg gttttcaagt ggaagtagcc   780
ctccagtaca atgacggatt ctcagataac attctatctt ttgtcaataa cgttcgcacc   840
aaggacggtg gaacgcacga gacaggactc aagtctgcca ttaccaaggt catgaatgac   900
tatgcacgta aaacaggtct tctcaaggaa aaagataaaa accttgaagg ttcagactat   960
cgtgagggac tagcggccgt tctttctatc ttagttcctg aagaacactt gcagtttgaa   1020
ggacagacca aggataaact aggaagcccc ctagctcgcc cagttgtgga tggaatagtg   1080
gctgataagt tgaccttttt ccttatggaa aatggggaat tagcttctaa cctcatccgc   1140
aaggctatca aggcccgtga tgctcgtgaa gcagcacgta aggcgcgtga tgagagccga   1200
aatgggaaga aaaacaagaa agataagggc ttgttgtctg ggaaattgac cccagcccaa   1260
tctaagaatc ctgctaagaa tgaactctat ctagttgagg gggactctgc cggtggttct   1320
gccaaacaag gtcgtgaccg caagttccag gctattctac ctcttcgtgg taaggttgtc   1380
aatacagcca aggccaagat ggcggatatc ctcaaaaatg aagagatcaa taccatgatt   1440
tataccattg gtgcgggtgt tggagcagac ttctctattg aagatgccaa ctatgataag   1500
atcattatca tgaccgatgc ggataccgac ggtgcccata tccagacctt gctcttgaca   1560
tttttctacc gttacatgcg tccgctagtc gaggcaggtc atgtctatat tgccctccca   1620
cctctttaca agatgtccaa aggtaaaggc aagaaagaag aagtggccta cgcttggacg   1680
gacggagaac tagaagaact ccgtaaacag ttcggtaaag gcgctaccct ccaacgatac   1740
aaaggacttg gtgagatgaa tgcggaccag ctctgggaaa caaccatgaa cccagaaaca   1800
cgtaccctca tccgtgtcac aattgaagat ttagcgcgcg ccgaacgccg cgtcaatgtt   1860
ctcatgggag ataaggtaga accacgccgt aaatggattg aagataatgt caagtttacg   1920
ctagaagaaa cgacagtgtt t                                             1941

<210>   1636
<211>   647
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   topoisomerase IV, subunit B (parE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902800 (0.E+01)

<400>   1636
Met Ser Lys Lys Glu Ile Asn Ile Asn Asn Tyr Asn Asp Asp Ala Ile 
1               5                   10                  15      

Gln Val Leu Glu Gly Leu Asp Ala Val Arg Lys Arg Pro Gly Met Tyr 
            20                  25                  30          

Ile Gly Ser Thr Asp Gly Ala Gly Leu His His Leu Val Trp Glu Ile 
        35                  40                  45              

Val Asp Asn Ala Val Asp Glu Ala Leu Ser Gly Phe Gly Asp Arg Ile 
    50                  55                  60                  

Asp Val Thr Ile Asn Lys Asp Gly Ser Leu Thr Val Gln Asp His Gly 
65                  70                  75                  80  

Arg Gly Met Pro Thr Gly Met His Ala Met Gly Ile Pro Thr Val Glu 

                85                  90                  95      

Val Ile Phe Thr Ile Leu His Ala Gly Gly Lys Phe Gly Gln Gly Gly 
            100                 105                 110         

Tyr Lys Thr Ser Gly Gly Leu His Gly Val Gly Ser Ser Val Val Asn 
        115                 120                 125             

Ala Leu Ser Ser Trp Leu Glu Val Glu Ile Thr Arg Asp Gly Ala Val 
    130                 135                 140                 

Tyr Lys Gln Arg Phe Glu Asn Gly Gly Lys Pro Val Thr Thr Leu Lys 
145                 150                 155                 160 

Lys Ile Gly Thr Ala Pro Lys Ser Lys Thr Gly Thr Lys Val Thr Phe 
                165                 170                 175     

Met Pro Asp Ala Thr Ile Phe Ser Thr Thr Asp Phe Lys Tyr Asn Thr 
            180                 185                 190         

Ile Ser Glu Arg Leu Asn Glu Ser Ala Phe Leu Leu Lys Asn Val Thr 
        195                 200                 205             

Leu Ser Leu Thr Asp Lys Arg Thr Asn Glu Ala Ile Glu Phe His Tyr 
    210                 215                 220                 

Glu Asn Gly Val Gln Asp Phe Val Ser Tyr Leu Asn Glu Asp Lys Glu 
225                 230                 235                 240 

Ile Leu Thr Pro Val Leu Tyr Phe Glu Gly Glu Asp Asn Gly Phe Gln 
                245                 250                 255     

Val Glu Val Ala Leu Gln Tyr Asn Asp Gly Phe Ser Asp Asn Ile Leu 
            260                 265                 270         

Ser Phe Val Asn Asn Val Arg Thr Lys Asp Gly Gly Thr His Glu Thr 
        275                 280                 285             

Gly Leu Lys Ser Ala Ile Thr Lys Val Met Asn Asp Tyr Ala Arg Lys 
    290                 295                 300                 

Thr Gly Leu Leu Lys Glu Lys Asp Lys Asn Leu Glu Gly Ser Asp Tyr 
305                 310                 315                 320 

Arg Glu Gly Leu Ala Ala Val Leu Ser Ile Leu Val Pro Glu Glu His 
                325                 330                 335     

Leu Gln Phe Glu Gly Gln Thr Lys Asp Lys Leu Gly Ser Pro Leu Ala 
            340                 345                 350         

Arg Pro Val Val Asp Gly Ile Val Ala Asp Lys Leu Thr Phe Phe Leu 
        355                 360                 365             

Met Glu Asn Gly Glu Leu Ala Ser Asn Leu Ile Arg Lys Ala Ile Lys 
    370                 375                 380                 

Ala Arg Asp Ala Arg Glu Ala Ala Arg Lys Ala Arg Asp Glu Ser Arg 
385                 390                 395                 400 

Asn Gly Lys Lys Asn Lys Lys Asp Lys Gly Leu Leu Ser Gly Lys Leu 
                405                 410                 415     

Thr Pro Ala Gln Ser Lys Asn Pro Ala Lys Asn Glu Leu Tyr Leu Val 
            420                 425                 430         

Glu Gly Asp Ser Ala Gly Gly Ser Ala Lys Gln Gly Arg Asp Arg Lys 
        435                 440                 445             

Phe Gln Ala Ile Leu Pro Leu Arg Gly Lys Val Val Asn Thr Ala Lys 
    450                 455                 460                 

Ala Lys Met Ala Asp Ile Leu Lys Asn Glu Glu Ile Asn Thr Met Ile 
465                 470                 475                 480 

Tyr Thr Ile Gly Ala Gly Val Gly Ala Asp Phe Ser Ile Glu Asp Ala 
                485                 490                 495     

Asn Tyr Asp Lys Ile Ile Ile Met Thr Asp Ala Asp Thr Asp Gly Ala 
            500                 505                 510         

His Ile Gln Thr Leu Leu Leu Thr Phe Phe Tyr Arg Tyr Met Arg Pro 
        515                 520                 525             

Leu Val Glu Ala Gly His Val Tyr Ile Ala Leu Pro Pro Leu Tyr Lys 
    530                 535                 540                 

Met Ser Lys Gly Lys Gly Lys Lys Glu Glu Val Ala Tyr Ala Trp Thr 
545                 550                 555                 560 

Asp Gly Glu Leu Glu Glu Leu Arg Lys Gln Phe Gly Lys Gly Ala Thr 
                565                 570                 575     

Leu Gln Arg Tyr Lys Gly Leu Gly Glu Met Asn Ala Asp Gln Leu Trp 
            580                 585                 590         

Glu Thr Thr Met Asn Pro Glu Thr Arg Thr Leu Ile Arg Val Thr Ile 
        595                 600                 605             

Glu Asp Leu Ala Arg Ala Glu Arg Arg Val Asn Val Leu Met Gly Asp 
    610                 615                 620                 

Lys Val Glu Pro Arg Arg Lys Trp Ile Glu Asp Asn Val Lys Phe Thr 
625                 630                 635                 640 

Leu Glu Glu Thr Thr Val Phe 
                645         

<210>   1637
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1637
atgaaagaaa ataatatgtt agtaaactgg aaattagagt cggatgtgaa tgactatgtg   60
aaaaagcagt ttgaaaatct tggtttgaaa aaattgcagg attat                   105

<210>   1638
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1638
Met Lys Glu Asn Asn Met Leu Val Asn Trp Lys Leu Glu Ser Asp Val 
1               5                   10                  15      

Asn Asp Tyr Val Lys Lys Gln Phe Glu Asn Leu Gly Leu Lys Lys Leu 
            20                  25                  30          

Gln Asp Tyr 
        35  

<210>   1639
<211>   123

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1639
atgagtgctt atctcaaaga ggcgcttaag ggagcggcta agacacaaac taagactaat   60
tttggaaaac cagattttca tattgaaaaa tacaaacagg atagtttggt tacttatcgt   120
aac                                                                 123

<210>   1640
<211>   41
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1640
Met Ser Ala Tyr Leu Lys Glu Ala Leu Lys Gly Ala Ala Lys Thr Gln 
1               5                   10                  15      

Thr Lys Thr Asn Phe Gly Lys Pro Asp Phe His Ile Glu Lys Tyr Lys 
            20                  25                  30          

Gln Asp Ser Leu Val Thr Tyr Arg Asn 
        35                  40      

<210>   1641
<211>   2478
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1641
ttgtatctta tgtctaacat tcaaaacatg tccctggagg acatcatggg agagcgcttt   60
ggtcgctact ccaagtacat tattcaagac cgggctttgc cagatattcg tgatgggttg   120
aagccggttc agcgccgtat tctttattct atgaataagg atagcaatac ttttgacaag   180
agctaccgta agtcggccaa gtcagtcggg aacatcatgg ggaatttcca cccacacggg   240
gattcttcta tctatgatgc catggttcgt atgtcacaga actggaaaaa tcgtgagatt   300
ctagttgaaa tgcacggtaa taacggttct atggacggag atcctcctgc ggctatgcgt   360
tatactgagg cacgtttgtc tgaaattgca ggctaccttc ttcaggatat cgagaaaaag   420
acagttcctt ttgcatggaa ctttgacgat acggagaaag aaccaacggt cttgccagca   480
gcctttccaa acctcttggt caatggttcg actgggattt cggctggtta tgccacagac   540
attcctcccc ataatttagc tgaggtcata gatgctgcag tttacatgat tgaccaccca   600
actgcaaaga ttgataaact catggaattc ttgcctggac cagacttccc tacaggggct   660
attattcagg gtcgtgatga aatcaagaaa gcttatgaga ctgggaaagg gcgcgtggtt   720
gttcgttcca agactgaaat tgaaaagcta aaaggtggta aggaacaaat cgttattatt   780
gagattcctt atgaaatcaa taaggccaat ctagtcaaga aaatcgatga tgttcgtgtt   840
aataacaagg tagctgggat tgctgaggtt cgtgatgagt ctgaccgtga tggtcttcgt   900
atcgctatcg aacttaagaa agacgctaat actgagcttg ttctcaacta cttatttaag   960
tacaccgacc tacaaatcaa ctacaacttt aatatggtgg cgattgacaa tttcacacct   1020
cgtcaggttg ggattgttcc aatcctgtct agctatatcg ctcaccgtcg agaagtgatt   1080
ttggcgcgtt cacgctttga caaagaaaag gctgagaaac gtctccatat cgtcgaaggt   1140
ttgattcgtg tgatttcgat tttggatgaa gtcattgctc ttatccgtgc ttctgagaat   1200
aaggcggacg ccaaggaaaa cctcaaagtt agctatgatt ttacggaaga acaggctgag   1260
gctatcgtaa ctttgcaact gtaccgtttg accaataccg atgtggttgt cttgcaggaa   1320
gaagaagcag agcttcgtga gaagattgct atgctggcgg ctattatcgg tgatgaaagg   1380
actatgtaca atctcatgaa gaaagaactt cgtgaggtca agaagaaatt tgcaactcct   1440
cgtttgagtt ctttagaaga cactgcgaaa gcaattgaga ttgatacagc tagtcttatc   1500
gctgaggaag atacctacgt cagcgtgacc aaggcaggtt acatcaagcg taccagtcca   1560
cgttcctttg cggcttccac cttggaagaa attggcaagc gtgatgatga ccgtttgatt   1620
tttgttcaat ctgccaagac aacccagcac ctcttgatgt tcacaagtct tggaaatgtc   1680
atctacagac caatccatga gttggcagat attcgttgga aggacatcgg agagcatctg   1740
agccaaacca tcacaaactt tgaaacgaat gaagaaatcc tttatgtgga agtactggat   1800
cagtttgacg atgcgacaac ctactttgca gtgactcgcc ttggtcaaat caaacgggta   1860
gagcgaaaag aattcactcc atggcggacc tatagatcta agtctgtcaa gtatgctaag   1920
ctcaaagacg atacagatca gattgtagca gtggctccga ttaaactaga tgatgttgtc   1980
ttggttagtc aaaatggtta tgccctgcgt ttcaatatcg aagaggttcc ggttgtcggt   2040
gctaaggcag caggtgtcaa ggctatgaat ttgaaagaag atgatgtcct ccaatctggc   2100
tttatctgta atacttcgtc cttctacctc ttgacccagc gtggaagctt gaaacgtgtt   2160
tccattgagg aaattctagc aaccagccgt gccaaacgag gattacaagt cttgcgtgag   2220
ttgaaaaaca aaccgcatcg tgtcttcttg gcaggagcag ttgcagagca aggatttgtt   2280
ggcgatttct tcagtacgga agtggatgtg aacgaccaaa ctctgcttgt ccaatccaat   2340
aaaggaacaa tctatgaaag ccgattgcaa gacttgaact tgtcagaacg cactagcaat   2400
ggaagcttca tttctgacac gatttcagat gaagaagttt ttgacgctta tcttcaggaa   2460
gtagttactg aagataaa                                                 2478

<210>   1642
<211>   826
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   topoisomerase IV, subunit A (parC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902801 (0.E+01)

<400>   1642
Met Tyr Leu Met Ser Asn Ile Gln Asn Met Ser Leu Glu Asp Ile Met 
1               5                   10                  15      

Gly Glu Arg Phe Gly Arg Tyr Ser Lys Tyr Ile Ile Gln Asp Arg Ala 
            20                  25                  30          


Leu Pro Asp Ile Arg Asp Gly Leu Lys Pro Val Gln Arg Arg Ile Leu 
        35                  40                  45              

Tyr Ser Met Asn Lys Asp Ser Asn Thr Phe Asp Lys Ser Tyr Arg Lys 
    50                  55                  60                  

Ser Ala Lys Ser Val Gly Asn Ile Met Gly Asn Phe His Pro His Gly 
65                  70                  75                  80  

Asp Ser Ser Ile Tyr Asp Ala Met Val Arg Met Ser Gln Asn Trp Lys 
                85                  90                  95      

Asn Arg Glu Ile Leu Val Glu Met His Gly Asn Asn Gly Ser Met Asp 
            100                 105                 110         

Gly Asp Pro Pro Ala Ala Met Arg Tyr Thr Glu Ala Arg Leu Ser Glu 
        115                 120                 125             

Ile Ala Gly Tyr Leu Leu Gln Asp Ile Glu Lys Lys Thr Val Pro Phe 
    130                 135                 140                 

Ala Trp Asn Phe Asp Asp Thr Glu Lys Glu Pro Thr Val Leu Pro Ala 
145                 150                 155                 160 

Ala Phe Pro Asn Leu Leu Val Asn Gly Ser Thr Gly Ile Ser Ala Gly 
                165                 170                 175     

Tyr Ala Thr Asp Ile Pro Pro His Asn Leu Ala Glu Val Ile Asp Ala 
            180                 185                 190         

Ala Val Tyr Met Ile Asp His Pro Thr Ala Lys Ile Asp Lys Leu Met 
        195                 200                 205             

Glu Phe Leu Pro Gly Pro Asp Phe Pro Thr Gly Ala Ile Ile Gln Gly 
    210                 215                 220                 

Arg Asp Glu Ile Lys Lys Ala Tyr Glu Thr Gly Lys Gly Arg Val Val 
225                 230                 235                 240 

Val Arg Ser Lys Thr Glu Ile Glu Lys Leu Lys Gly Gly Lys Glu Gln 
                245                 250                 255     

Ile Val Ile Ile Glu Ile Pro Tyr Glu Ile Asn Lys Ala Asn Leu Val 
            260                 265                 270         

Lys Lys Ile Asp Asp Val Arg Val Asn Asn Lys Val Ala Gly Ile Ala 
        275                 280                 285             

Glu Val Arg Asp Glu Ser Asp Arg Asp Gly Leu Arg Ile Ala Ile Glu 
    290                 295                 300                 

Leu Lys Lys Asp Ala Asn Thr Glu Leu Val Leu Asn Tyr Leu Phe Lys 
305                 310                 315                 320 

Tyr Thr Asp Leu Gln Ile Asn Tyr Asn Phe Asn Met Val Ala Ile Asp 
                325                 330                 335     

Asn Phe Thr Pro Arg Gln Val Gly Ile Val Pro Ile Leu Ser Ser Tyr 
            340                 345                 350         

Ile Ala His Arg Arg Glu Val Ile Leu Ala Arg Ser Arg Phe Asp Lys 
        355                 360                 365             

Glu Lys Ala Glu Lys Arg Leu His Ile Val Glu Gly Leu Ile Arg Val 
    370                 375                 380                 

Ile Ser Ile Leu Asp Glu Val Ile Ala Leu Ile Arg Ala Ser Glu Asn 
385                 390                 395                 400 

Lys Ala Asp Ala Lys Glu Asn Leu Lys Val Ser Tyr Asp Phe Thr Glu 
                405                 410                 415     

Glu Gln Ala Glu Ala Ile Val Thr Leu Gln Leu Tyr Arg Leu Thr Asn 
            420                 425                 430         

Thr Asp Val Val Val Leu Gln Glu Glu Glu Ala Glu Leu Arg Glu Lys 
        435                 440                 445             

Ile Ala Met Leu Ala Ala Ile Ile Gly Asp Glu Arg Thr Met Tyr Asn 
    450                 455                 460                 

Leu Met Lys Lys Glu Leu Arg Glu Val Lys Lys Lys Phe Ala Thr Pro 
465                 470                 475                 480 

Arg Leu Ser Ser Leu Glu Asp Thr Ala Lys Ala Ile Glu Ile Asp Thr 
                485                 490                 495     

Ala Ser Leu Ile Ala Glu Glu Asp Thr Tyr Val Ser Val Thr Lys Ala 
            500                 505                 510         

Gly Tyr Ile Lys Arg Thr Ser Pro Arg Ser Phe Ala Ala Ser Thr Leu 
        515                 520                 525             

Glu Glu Ile Gly Lys Arg Asp Asp Asp Arg Leu Ile Phe Val Gln Ser 
    530                 535                 540                 

Ala Lys Thr Thr Gln His Leu Leu Met Phe Thr Ser Leu Gly Asn Val 
545                 550                 555                 560 

Ile Tyr Arg Pro Ile His Glu Leu Ala Asp Ile Arg Trp Lys Asp Ile 
                565                 570                 575     

Gly Glu His Leu Ser Gln Thr Ile Thr Asn Phe Glu Thr Asn Glu Glu 
            580                 585                 590         

Ile Leu Tyr Val Glu Val Leu Asp Gln Phe Asp Asp Ala Thr Thr Tyr 
        595                 600                 605             

Phe Ala Val Thr Arg Leu Gly Gln Ile Lys Arg Val Glu Arg Lys Glu 
    610                 615                 620                 

Phe Thr Pro Trp Arg Thr Tyr Arg Ser Lys Ser Val Lys Tyr Ala Lys 
625                 630                 635                 640 

Leu Lys Asp Asp Thr Asp Gln Ile Val Ala Val Ala Pro Ile Lys Leu 
                645                 650                 655     

Asp Asp Val Val Leu Val Ser Gln Asn Gly Tyr Ala Leu Arg Phe Asn 
            660                 665                 670         

Ile Glu Glu Val Pro Val Val Gly Ala Lys Ala Ala Gly Val Lys Ala 
        675                 680                 685             

Met Asn Leu Lys Glu Asp Asp Val Leu Gln Ser Gly Phe Ile Cys Asn 
    690                 695                 700                 

Thr Ser Ser Phe Tyr Leu Leu Thr Gln Arg Gly Ser Leu Lys Arg Val 
705                 710                 715                 720 

Ser Ile Glu Glu Ile Leu Ala Thr Ser Arg Ala Lys Arg Gly Leu Gln 
                725                 730                 735     

Val Leu Arg Glu Leu Lys Asn Lys Pro His Arg Val Phe Leu Ala Gly 
            740                 745                 750         

Ala Val Ala Glu Gln Gly Phe Val Gly Asp Phe Phe Ser Thr Glu Val 
        755                 760                 765             

Asp Val Asn Asp Gln Thr Leu Leu Val Gln Ser Asn Lys Gly Thr Ile 
    770                 775                 780                 

Tyr Glu Ser Arg Leu Gln Asp Leu Asn Leu Ser Glu Arg Thr Ser Asn 
785                 790                 795                 800 

Gly Ser Phe Ile Ser Asp Thr Ile Ser Asp Glu Glu Val Phe Asp Ala 
                805                 810                 815     

Tyr Leu Gln Glu Val Val Thr Glu Asp Lys 
            820                 825     

<210>   1643
<211>   1020
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1643
atgacagtaa cgattgattg ggaaaacctc ggtttttcct atatgaaatt accttatcgc   60
tatcttgctc atttcaaaaa tggacaatgg gatcaaggag agcttacaga ggatgcaact   120
ttgcatattt cagagtcttc tccaagtctt cactatggac aacaagcatt tgaaggtttg   180
aaagcttatc gtactaagga tggcagtgtt caactgttcc gtcctgatga aaatgctaaa   240
cgtctgcaac gtacatgtga ccgtctcttg atgccacaag ttccgacaga catgtttgta   300
gaagcttgta aagcagttgt ccgtgcgaat gaagaatacg taccaccata cggaacaggt   360
ggaaccttat atcttcgccc tcttttgatt ggtgtcggag atattatcgg ggtaaaaccg   420
gcagaagagt acattttcac catctttgct atgccagttg gaaattactt taaaggtggt   480
ttggtcccaa ccaacttctt gattcaggat gagtacgacc gtgcagcacc aaatggtaca   540
ggtgcggcta aggttggtgg aaactatgct gcaagtctct taccaggaaa aatggccaag   600
tcacgtcatt tctcagatgt tatctatctg gacccatcaa ctcatacaaa gattgaagaa   660
gtcggatcag ctaacttctt tggaattaca gctgataatg aatttgtaac accattgagt   720
ccatctatct tgccatctat taccaagtat tccttgcttt atttggcaga acatcgcttg   780
ggattaactc ctattgaggg tgatgttcca attgataatc ttgaccgttt tgtagaggca   840
ggtgcctgtg gtacagcagc ggttatttct ccaattggag gtattcaaca tggtgatgat   900
ttccatgtat tctatagtga aacagaagta ggtcctgtga cgcgtaaatt atataatgaa   960
ttgacgggta ttcagtttgg cgatattgaa gcgccagaag gttggattgt aaaagtagat   1020

<210>   1644
<211>   340
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   branched-chain amino acid aminotransferase (ilvE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902802 (0.E+01)

<400>   1644
Met Thr Val Thr Ile Asp Trp Glu Asn Leu Gly Phe Ser Tyr Met Lys 
1               5                   10                  15      

Leu Pro Tyr Arg Tyr Leu Ala His Phe Lys Asn Gly Gln Trp Asp Gln 
            20                  25                  30          

Gly Glu Leu Thr Glu Asp Ala Thr Leu His Ile Ser Glu Ser Ser Pro 
        35                  40                  45              

Ser Leu His Tyr Gly Gln Gln Ala Phe Glu Gly Leu Lys Ala Tyr Arg 
    50                  55                  60                  

Thr Lys Asp Gly Ser Val Gln Leu Phe Arg Pro Asp Glu Asn Ala Lys 
65                  70                  75                  80  

Arg Leu Gln Arg Thr Cys Asp Arg Leu Leu Met Pro Gln Val Pro Thr 
                85                  90                  95      

Asp Met Phe Val Glu Ala Cys Lys Ala Val Val Arg Ala Asn Glu Glu 
            100                 105                 110         

Tyr Val Pro Pro Tyr Gly Thr Gly Gly Thr Leu Tyr Leu Arg Pro Leu 
        115                 120                 125             


Leu Ile Gly Val Gly Asp Ile Ile Gly Val Lys Pro Ala Glu Glu Tyr 
    130                 135                 140                 

Ile Phe Thr Ile Phe Ala Met Pro Val Gly Asn Tyr Phe Lys Gly Gly 
145                 150                 155                 160 

Leu Val Pro Thr Asn Phe Leu Ile Gln Asp Glu Tyr Asp Arg Ala Ala 
                165                 170                 175     

Pro Asn Gly Thr Gly Ala Ala Lys Val Gly Gly Asn Tyr Ala Ala Ser 
            180                 185                 190         

Leu Leu Pro Gly Lys Met Ala Lys Ser Arg His Phe Ser Asp Val Ile 
        195                 200                 205             

Tyr Leu Asp Pro Ser Thr His Thr Lys Ile Glu Glu Val Gly Ser Ala 
    210                 215                 220                 

Asn Phe Phe Gly Ile Thr Ala Asp Asn Glu Phe Val Thr Pro Leu Ser 
225                 230                 235                 240 

Pro Ser Ile Leu Pro Ser Ile Thr Lys Tyr Ser Leu Leu Tyr Leu Ala 
                245                 250                 255     

Glu His Arg Leu Gly Leu Thr Pro Ile Glu Gly Asp Val Pro Ile Asp 
            260                 265                 270         

Asn Leu Asp Arg Phe Val Glu Ala Gly Ala Cys Gly Thr Ala Ala Val 
        275                 280                 285             

Ile Ser Pro Ile Gly Gly Ile Gln His Gly Asp Asp Phe His Val Phe 
    290                 295                 300                 

Tyr Ser Glu Thr Glu Val Gly Pro Val Thr Arg Lys Leu Tyr Asn Glu 
305                 310                 315                 320 

Leu Thr Gly Ile Gln Phe Gly Asp Ile Glu Ala Pro Glu Gly Trp Ile 
                325                 330                 335     

Val Lys Val Asp 
            340 

<210>   1645
<211>   702
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1645
gtggtcctga gcacgtcagc tattttagtg gcttgtggaa aaactgataa agaagcagat   60
gcaccgacaa cattttctta tgtctatgca gtagatccag catcattggg ctacagtata   120
gcgactcgaa catcgaggac agacgttatt ggaaatgtta ttgatggttt gatggaaaat   180
gataaatacg gcaatgttgc tccttctcaa aaagactatg atttgaacag tacaggatgg   240
gctccaagct atcaagatcc agcgtctcac ttgaatatta tagatccaaa atctggttct   300
gccatgaaac accttggtat tacgaaagga aaagataagg atgttgtagc taaacctggt   360
ttggataaat ataagaaatt gttagaagat gctgtttctg agaccactga cctagagaaa   420
agatatgaaa aatatgccaa agctcaagct tggtcgacag atagttcatt attgatgcca   480
acagcttcat ctggtggttc tccagttgta agtaacgtag taccattctc aaaaccatac   540
tcacaagttg gtattaaggg ggatccatat atctttaaag gaatgaaatt gcaaaaagat   600
attgttacaa caaaagaata taacgaggtt tttaaaaaat ggcaaaaaga aaaattggaa   660
tccaatagca aataccaaaa agaactagaa aaacacatta aa                      702

<210>   1646
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligopeptide-binding protein, internal deletion, POINT MUTATION
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902804 (e-125)

<400>   1646
Met Val Leu Ser Thr Ser Ala Ile Leu Val Ala Cys Gly Lys Thr Asp 
1               5                   10                  15      

Lys Glu Ala Asp Ala Pro Thr Thr Phe Ser Tyr Val Tyr Ala Val Asp 
            20                  25                  30          

Pro Ala Ser Leu Gly Tyr Ser Ile Ala Thr Arg Thr Ser Arg Thr Asp 
        35                  40                  45              

Val Ile Gly Asn Val Ile Asp Gly Leu Met Glu Asn Asp Lys Tyr Gly 
    50                  55                  60                  

Asn Val Ala Pro Ser Gln Lys Asp Tyr Asp Leu Asn Ser Thr Gly Trp 
65                  70                  75                  80  

Ala Pro Ser Tyr Gln Asp Pro Ala Ser His Leu Asn Ile Ile Asp Pro 
                85                  90                  95      

Lys Ser Gly Ser Ala Met Lys His Leu Gly Ile Thr Lys Gly Lys Asp 
            100                 105                 110         

Lys Asp Val Val Ala Lys Pro Gly Leu Asp Lys Tyr Lys Lys Leu Leu 
        115                 120                 125             

Glu Asp Ala Val Ser Glu Thr Thr Asp Leu Glu Lys Arg Tyr Glu Lys 
    130                 135                 140                 

Tyr Ala Lys Ala Gln Ala Trp Ser Thr Asp Ser Ser Leu Leu Met Pro 
145                 150                 155                 160 

Thr Ala Ser Ser Gly Gly Ser Pro Val Val Ser Asn Val Val Pro Phe 
                165                 170                 175     

Ser Lys Pro Tyr Ser Gln Val Gly Ile Lys Gly Asp Pro Tyr Ile Phe 
            180                 185                 190         

Lys Gly Met Lys Leu Gln Lys Asp Ile Val Thr Thr Lys Glu Tyr Asn 
        195                 200                 205             

Glu Val Phe Lys Lys Trp Gln Lys Glu Lys Leu Glu Ser Asn Ser Lys 
    210                 215                 220                 

Tyr Gln Lys Glu Leu Glu Lys His Ile Lys 
225                 230                 

<210>   1647
<211>   708
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1647
ttgaatataa aggagtttga tatggagtgg attagattaa taggaatagc aatcattgtt   60
gtgggtttta ttttaaaatt tgatacaatt gcaacagtag tcttagctgg tttggttaca   120
gctttagttt caggtgtttc tctcgttgaa tttttggaga ttttgggaaa agaatttagc   180
aatcagcgag tgctcacgat ttttatggtt accttgcctc ttgtggggct gtcagaaacc   240
tttggactca agcaacgatc aatcgatttg attcgaaaga ttaaaggtct gacagttgga   300
aacttctata cagtttattt ctttattcga gagttagctg gtttcttttc aattcgtcta   360
ggaggacacc ctcagtttgt cagacctttg gttcaaccta tgggagaagc agctgcagag   420
tctcaattag gtagaaagtt aacagaggtt gaagatgaga caataaaagc gcgtgcggct   480
gcgaatgaaa attttggaaa tttctttgct caaaatacgt ttgtaggtgc tgggggagtc   540
ctcttgatag ggggaacatt agatcagtta ggctatgaaa gcaattatgc agggattgct   600
tctacatcta ttattgttgc tgttataaca cttattgtag tggggattta taattattta   660
tttgataaaa aattgatatc aaaaaagact aggggaggag aacaaaaa                708

<210>   1648
<211>   236
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902371 (0.E+01)

<400>   1648
Met Asn Ile Lys Glu Phe Asp Met Glu Trp Ile Arg Leu Ile Gly Ile 
1               5                   10                  15      

Ala Ile Ile Val Val Gly Phe Ile Leu Lys Phe Asp Thr Ile Ala Thr 
            20                  25                  30          

Val Val Leu Ala Gly Leu Val Thr Ala Leu Val Ser Gly Val Ser Leu 
        35                  40                  45              

Val Glu Phe Leu Glu Ile Leu Gly Lys Glu Phe Ser Asn Gln Arg Val 
    50                  55                  60                  

Leu Thr Ile Phe Met Val Thr Leu Pro Leu Val Gly Leu Ser Glu Thr 
65                  70                  75                  80  

Phe Gly Leu Lys Gln Arg Ser Ile Asp Leu Ile Arg Lys Ile Lys Gly 
                85                  90                  95      

Leu Thr Val Gly Asn Phe Tyr Thr Val Tyr Phe Phe Ile Arg Glu Leu 
            100                 105                 110         

Ala Gly Phe Phe Ser Ile Arg Leu Gly Gly His Pro Gln Phe Val Arg 
        115                 120                 125             

Pro Leu Val Gln Pro Met Gly Glu Ala Ala Ala Glu Ser Gln Leu Gly 
    130                 135                 140                 

Arg Lys Leu Thr Glu Val Glu Asp Glu Thr Ile Lys Ala Arg Ala Ala 
145                 150                 155                 160 

Ala Asn Glu Asn Phe Gly Asn Phe Phe Ala Gln Asn Thr Phe Val Gly 
                165                 170                 175     

Ala Gly Gly Val Leu Leu Ile Gly Gly Thr Leu Asp Gln Leu Gly Tyr 
            180                 185                 190         

Glu Ser Asn Tyr Ala Gly Ile Ala Ser Thr Ser Ile Ile Val Ala Val 
        195                 200                 205             

Ile Thr Leu Ile Val Val Gly Ile Tyr Asn Tyr Leu Phe Asp Lys Lys 
    210                 215                 220                 

Leu Ile Ser Lys Lys Thr Arg Gly Gly Glu Gln Lys 
225                 230                 235     

<210>   1649
<211>   921
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1649
atgacagagt tggcaaagca actattagag ttgacctata ttgtgattgg ttgtcaattt   60
ctccatacag cctattgtag ttataaagat aaaacaaacc cagttcgact tgggacatct   120
gcattttgga ctctattgtc tattacgttt ataggtggtt cctatatgcc aaatatgagt   180
attggtatta ttgtaatcct attatcgctg ttaacattgt ttaagcaagt ccgtatcgga   240
accttgccat ccttagatga aatgaaagcc aatattgaat ctaacaggtt gaaaaataaa   300
atttttattc cagttatgct gatggcaata cttgcgttgg tcttagcgca aatgattcca   360
gaatttagca agatttcgat tagccttgcc gccttgtttg ctacaatttc tgttcttgtg   420
attaccaata gtcaccctaa gagtctgtta tcagaaaata atcgaatgac tcagcaagtt   480
tcaacaagtg ggattgttcc tcaattatta ggggctttgg gggctatttt tactgtagca   540
ggtgttggtg atgttatctc tcatctgatt agcggtattg ttccttcaga tagtcgcttt   600
ataggagttt tggcctatgt tcttggaatg gttctattca caatgattat gggaaatgct   660
tttgcagcat tcaccgttat tacagcaggt gttggagttc cctttgtatt tgctctggga   720
gctaatccaa ttgtggctgg tgctcttgcc atgacagcag gttattgtgg gaccttattg   780
accccaatgg ctgctaattt taacgctcta ccagcagcat tgatggatat gaaagatcag   840
aatggcgtta taaaggctca agcaggtgtt gctctagtaa tgattgttat tcacatattc   900
ttaatgtact ttctcgcatt t                                             921

<210>   1650
<211>   307
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902805 (e-169)

<400>   1650
Met Thr Glu Leu Ala Lys Gln Leu Leu Glu Leu Thr Tyr Ile Val Ile 
1               5                   10                  15      

Gly Cys Gln Phe Leu His Thr Ala Tyr Cys Ser Tyr Lys Asp Lys Thr 
            20                  25                  30          

Asn Pro Val Arg Leu Gly Thr Ser Ala Phe Trp Thr Leu Leu Ser Ile 
        35                  40                  45              

Thr Phe Ile Gly Gly Ser Tyr Met Pro Asn Met Ser Ile Gly Ile Ile 
    50                  55                  60                  

Val Ile Leu Leu Ser Leu Leu Thr Leu Phe Lys Gln Val Arg Ile Gly 
65                  70                  75                  80  

Thr Leu Pro Ser Leu Asp Glu Met Lys Ala Asn Ile Glu Ser Asn Arg 
                85                  90                  95      

Leu Lys Asn Lys Ile Phe Ile Pro Val Met Leu Met Ala Ile Leu Ala 
            100                 105                 110         

Leu Val Leu Ala Gln Met Ile Pro Glu Phe Ser Lys Ile Ser Ile Ser 
        115                 120                 125             

Leu Ala Ala Leu Phe Ala Thr Ile Ser Val Leu Val Ile Thr Asn Ser 
    130                 135                 140                 

His Pro Lys Ser Leu Leu Ser Glu Asn Asn Arg Met Thr Gln Gln Val 
145                 150                 155                 160 

Ser Thr Ser Gly Ile Val Pro Gln Leu Leu Gly Ala Leu Gly Ala Ile 
                165                 170                 175     

Phe Thr Val Ala Gly Val Gly Asp Val Ile Ser His Leu Ile Ser Gly 
            180                 185                 190         

Ile Val Pro Ser Asp Ser Arg Phe Ile Gly Val Leu Ala Tyr Val Leu 
        195                 200                 205             

Gly Met Val Leu Phe Thr Met Ile Met Gly Asn Ala Phe Ala Ala Phe 
    210                 215                 220                 

Thr Val Ile Thr Ala Gly Val Gly Val Pro Phe Val Phe Ala Leu Gly 
225                 230                 235                 240 

Ala Asn Pro Ile Val Ala Gly Ala Leu Ala Met Thr Ala Gly Tyr Cys 
                245                 250                 255     

Gly Thr Leu Leu Thr Pro Met Ala Ala Asn Phe Asn Ala Leu Pro Ala 
            260                 265                 270         

Ala Leu Met Asp Met Lys Asp Gln Asn Gly Val Ile Lys Ala Gln Ala 
        275                 280                 285             

Gly Val Ala Leu Val Met Ile Val Ile His Ile Phe Leu Met Tyr Phe 
    290                 295                 300                 

Leu Ala Phe 
305         

<210>   1651
<211>   642
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1651
atgaaaatat tggttacagg ttttaatcct tttggaggtg aaaagattaa tccagctttg   60
gaggctgtaa aattattacc atctgagatt aatggggctg aagttcgctg ggtagaaatt   120
ccaacggttt tttataagtc gtcagaagtt ttagaggcag aaatattacg atatcaacca   180
gatgctgtac tttgtattgg acaagcaggc ggcaggaccg gcttaacacc tgaacgagtg   240
gctattaatc aagatgatgc tcgcatacct gataacgaag gcaatcaacc aattgataca   300
ccgattcgta ttgatggagc atcggcctat tttagtagtt tacctatcaa agcgatggta   360
caagctatca aaaaacaggg acttccggca gttgtatcca atagtgcagg aacctttgtt   420
tgcaatcatt tgatgtacca agctctttat ttagtggata aaaaattccc taatatgaga   480
gcaggtttca tgcatattcc atatatgatg gaacaagtag taaataagcc gaatactgca   540
ggaatgagtc tatgtgatat tgtaagaggc atagaggtag ctattgaagc tattgtagac   600
tacaaagata aggatttgca gttagtaggc ggtgagactc ac                      642

<210>   1652
<211>   214
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyrrolidone-carboxylate peptidase (pcp)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902806 (e-122)

<400>   1652
Met Lys Ile Leu Val Thr Gly Phe Asn Pro Phe Gly Gly Glu Lys Ile 
1               5                   10                  15      

Asn Pro Ala Leu Glu Ala Val Lys Leu Leu Pro Ser Glu Ile Asn Gly 
            20                  25                  30          

Ala Glu Val Arg Trp Val Glu Ile Pro Thr Val Phe Tyr Lys Ser Ser 
        35                  40                  45              

Glu Val Leu Glu Ala Glu Ile Leu Arg Tyr Gln Pro Asp Ala Val Leu 
    50                  55                  60                  

Cys Ile Gly Gln Ala Gly Gly Arg Thr Gly Leu Thr Pro Glu Arg Val 
65                  70                  75                  80  

Ala Ile Asn Gln Asp Asp Ala Arg Ile Pro Asp Asn Glu Gly Asn Gln 
                85                  90                  95      

Pro Ile Asp Thr Pro Ile Arg Ile Asp Gly Ala Ser Ala Tyr Phe Ser 
            100                 105                 110         

Ser Leu Pro Ile Lys Ala Met Val Gln Ala Ile Lys Lys Gln Gly Leu 
        115                 120                 125             

Pro Ala Val Val Ser Asn Ser Ala Gly Thr Phe Val Cys Asn His Leu 
    130                 135                 140                 

Met Tyr Gln Ala Leu Tyr Leu Val Asp Lys Lys Phe Pro Asn Met Arg 
145                 150                 155                 160 

Ala Gly Phe Met His Ile Pro Tyr Met Met Glu Gln Val Val Asn Lys 
                165                 170                 175     

Pro Asn Thr Ala Gly Met Ser Leu Cys Asp Ile Val Arg Gly Ile Glu 
            180                 185                 190         

Val Ala Ile Glu Ala Ile Val Asp Tyr Lys Asp Lys Asp Leu Gln Leu 
        195                 200                 205             

Val Gly Gly Glu Thr His 
    210                 

<210>   1653
<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1653
atgagcaaga aagataaaaa aatcgaaatt caagtagcgg atgccaaagt taatgttggt   60
aaagacagtt ttgaaggtta tacattgact atcggtaaaa aagttatcgg agaaattgcc   120
gaattagacg gacaatttgc cattataaag aatgggaatg tcgatagttt ttataaaaaa   180
ttggaaaaag ctgtggaaat tttgattgaa aattataatt tagcaaaa                228

<210>   1654
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902807 (2.E-38)

<400>   1654
Met Ser Lys Lys Asp Lys Lys Ile Glu Ile Gln Val Ala Asp Ala Lys 
1               5                   10                  15      

Val Asn Val Gly Lys Asp Ser Phe Glu Gly Tyr Thr Leu Thr Ile Gly 
            20                  25                  30          

Lys Lys Val Ile Gly Glu Ile Ala Glu Leu Asp Gly Gln Phe Ala Ile 
        35                  40                  45              

Ile Lys Asn Gly Asn Val Asp Ser Phe Tyr Lys Lys Leu Glu Lys Ala 
    50                  55                  60                  

Val Glu Ile Leu Ile Glu Asn Tyr Asn Leu Ala Lys 
65                  70                  75      

<210>   1655
<211>   1200
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1655
atgaacgaat ttgaagattt gctaaatagc gttagtcaag ttgagactgg tgatgttgtt   60
agtgctgaag tattgacagt tgatgcgact caagctaacg ttgcaatctc tggaactggt   120
gttgaaggtg tcttgactct tcgcgaattg acaaacgatc gtgatgcaga tatcaatgac   180
tttgttaaag taggagaagt attggatgtt cttgtacttc gtcaagtagt tggtaaagat   240
actgatacag ttacatacct tgtatctaaa aaacgccttg aagctcgcaa agcatgggac   300
aaacttgttg gtcgcgaaga agaagttgtt actgttaaag gaacgcgtgc cgttaaaggt   360
ggactttcag tagaatttga aggtgttcgt ggatttatcc cagcttcaat gttggatact   420
cgtttcgtac gtaacgctga gcgttttgta ggtcaagaat ttgatactaa aatcaaagaa   480
gttaacgcta aagaaaaccg cttcatcctt tcacgtcgtg aagttgttga agcagctact   540
gcagcagctc gcgctgaagt attcggtaaa ttggctgttg gtgatgttgt aactggtaaa   600
gttgctcgta tcacaagctt cggcgctttc gtcgaccttg gtggtgttga cggattggtt   660
cacttgactg aattgtcaca tgaacgtaat gtatcaccaa aatcagttgt aactgttggt   720
gaagaaattg aagtgaaaat ccttgatctt aacgaagaag aaggacgtgt atcactttca   780
cttaaagcaa cagtaccagg accatgggat ggcgttgagc aaaaattggc taaaggtgat   840
gtagtagaag gaacagttaa acgtttgact gacttcggtg catttgttga agtattgcca   900
ggtatcgatg gacttgttca cgtatcacaa atttcacaca aacggattga aaatccaaaa   960
gaagctctta aagttggtca agaagttcaa gttaaagttc ttgaagttaa cgcagatgca   1020
gaacgcgtgt cactttctat taaagctctt gaagaacgtc cagcccaaga agaaggacaa   1080
aaagaagaaa aacgtgctgc tcgtccacgt cgtccaagac gtcaagaaaa gcgtgatttc   1140
gaacttccag aaacacaaac aggattttca atggctgatt tgtttggtga tatcgaactt   1200

<210>   1656
<211>   400
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S1 (rpsA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902808 (0.E+01)

<400>   1656
Met Asn Glu Phe Glu Asp Leu Leu Asn Ser Val Ser Gln Val Glu Thr 
1               5                   10                  15      

Gly Asp Val Val Ser Ala Glu Val Leu Thr Val Asp Ala Thr Gln Ala 
            20                  25                  30          

Asn Val Ala Ile Ser Gly Thr Gly Val Glu Gly Val Leu Thr Leu Arg 
        35                  40                  45              

Glu Leu Thr Asn Asp Arg Asp Ala Asp Ile Asn Asp Phe Val Lys Val 
    50                  55                  60                  

Gly Glu Val Leu Asp Val Leu Val Leu Arg Gln Val Val Gly Lys Asp 
65                  70                  75                  80  

Thr Asp Thr Val Thr Tyr Leu Val Ser Lys Lys Arg Leu Glu Ala Arg 
                85                  90                  95      

Lys Ala Trp Asp Lys Leu Val Gly Arg Glu Glu Glu Val Val Thr Val 
            100                 105                 110         

Lys Gly Thr Arg Ala Val Lys Gly Gly Leu Ser Val Glu Phe Glu Gly 
        115                 120                 125             

Val Arg Gly Phe Ile Pro Ala Ser Met Leu Asp Thr Arg Phe Val Arg 
    130                 135                 140                 

Asn Ala Glu Arg Phe Val Gly Gln Glu Phe Asp Thr Lys Ile Lys Glu 
145                 150                 155                 160 

Val Asn Ala Lys Glu Asn Arg Phe Ile Leu Ser Arg Arg Glu Val Val 
                165                 170                 175     

Glu Ala Ala Thr Ala Ala Ala Arg Ala Glu Val Phe Gly Lys Leu Ala 
            180                 185                 190         

Val Gly Asp Val Val Thr Gly Lys Val Ala Arg Ile Thr Ser Phe Gly 
        195                 200                 205             

Ala Phe Val Asp Leu Gly Gly Val Asp Gly Leu Val His Leu Thr Glu 
    210                 215                 220                 

Leu Ser His Glu Arg Asn Val Ser Pro Lys Ser Val Val Thr Val Gly 
225                 230                 235                 240 

Glu Glu Ile Glu Val Lys Ile Leu Asp Leu Asn Glu Glu Glu Gly Arg 
                245                 250                 255     

Val Ser Leu Ser Leu Lys Ala Thr Val Pro Gly Pro Trp Asp Gly Val 
            260                 265                 270         

Glu Gln Lys Leu Ala Lys Gly Asp Val Val Glu Gly Thr Val Lys Arg 
        275                 280                 285             

Leu Thr Asp Phe Gly Ala Phe Val Glu Val Leu Pro Gly Ile Asp Gly 
    290                 295                 300                 

Leu Val His Val Ser Gln Ile Ser His Lys Arg Ile Glu Asn Pro Lys 
305                 310                 315                 320 

Glu Ala Leu Lys Val Gly Gln Glu Val Gln Val Lys Val Leu Glu Val 
                325                 330                 335     

Asn Ala Asp Ala Glu Arg Val Ser Leu Ser Ile Lys Ala Leu Glu Glu 

            340                 345                 350         

Arg Pro Ala Gln Glu Glu Gly Gln Lys Glu Glu Lys Arg Ala Ala Arg 
        355                 360                 365             

Pro Arg Arg Pro Arg Arg Gln Glu Lys Arg Asp Phe Glu Leu Pro Glu 
    370                 375                 380                 

Thr Gln Thr Gly Phe Ser Met Ala Asp Leu Phe Gly Asp Ile Glu Leu 
385                 390                 395                 400 


<210>   1657
<211>   1324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1657
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatca tcaataaaga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accgtctaag   180
attccttacc ttgagacaac tggtatgcct actagaattc tacttagaaa gcgtcgtttc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ctatcgtcaa gaaaaatcac   300
caaattcctc gtattatcaa ccaaaaaatt gcgcaaaagt tgattgagaa gatttctatg   360
accgatattg ctcatcagct ggccatttca acttcaactg tcattcgaaa gctcaatgat   420
tctcactttg agcatgattt ttcgcgtctt cctgagatta tgtcctggga cgttgaaaca   480
gtccggggag tgactgtttc aatcgggaga tgaagatgag ctttattgcg caagattttg   540
acaagctcga tatcatcact gttcttgaag gtagaacaca agctatcatc cgagatcact   600
ttcttaaata tgatagagcc gtccgatgtc gcgtcaaaat cattactatg gatatgttta   660
gcccttacta tgacttagct agacaacttc gctttcaaat ttctaggctc aggctgaaac   720
agtctcccag actgtttcac tcccgaatgc taaaatcgtt cttgatcgct ttcatattgt   780
acaacatctt agccgtgcta tgagtcgtgt gcatgtccaa atcatgaatc agtttcatcg   840
aaagtctcat gaatacaagg ctatcaagcg ctactggaag ctcatacaac aggatagtcg   900
taaactgagt gataagcgat tttatcgtcc tacttttcgt atgcacttaa ccaataaaga   960
gattttaaac aagcttttga gttattcgga agacttgaaa caccactatc agctctatca   1020
actcttgctg tttcactttc agaataagga accggagaaa tttttcggac ttattgagga   1080
caatcttaag caggttcatc ctatttttca gactgtcttt aaaaccttcc tcaaagataa   1140
agaaaagctt gtcaacaccc ttcaactaca ctattctaac gccaaactgg aagcgaccaa   1200
taatctcatc aaacttatca agcgcaatgc ctttggtttt cggaactttg aaaacttcaa   1260
aaaacggatt tttatcgctc tgaatatcaa aaaagaaagg acaaaatttg tcctttctcg   1320
agct                                                                1324

<210>   1658
<211>   175
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase FRAMESHIFT

<400>   1658
Met Ser Arg Val His Val Gln Ile Met Asn Gln Phe His Arg Lys Ser 
1               5                   10                  15      

His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile Gln Gln Asp 
            20                  25                  30          

Ser Arg Lys Leu Ser Asp Lys Arg Phe Tyr Arg Pro Thr Phe Arg Met 
        35                  40                  45              

His Leu Thr Asn Lys Glu Ile Leu Asn Lys Leu Leu Ser Tyr Ser Glu 
    50                  55                  60                  

Asp Leu Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu Phe His Phe 
65                  70                  75                  80  

Gln Asn Lys Glu Pro Glu Lys Phe Phe Gly Leu Ile Glu Asp Asn Leu 
                85                  90                  95      

Lys Gln Val His Pro Ile Phe Gln Thr Val Phe Lys Thr Phe Leu Lys 
            100                 105                 110         

Asp Lys Glu Lys Leu Val Asn Thr Leu Gln Leu His Tyr Ser Asn Ala 
        115                 120                 125             

Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys Arg Asn Ala 
    130                 135                 140                 

Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile Phe Ile Ala 
145                 150                 155                 160 

Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser Arg Ala 
                165                 170                 175 

<210>   1659
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1659
atgagcttta ttgcgcaaga ttttgacaag ctcgatatca tcactgttct tgaaggtaga   60
acacaagcta tcatccgaga tcactttctt aaatatgata gagccgtccg atgtcgcgtc   120
aaaatcatta ctatggatat gtttagccct tactatgact tagctagaca acttcgcttt   180
caaatttcta ggctcaggct gaaacagtct cccagactgt ttcactcccg aatgctaaaa   240
tcgttcttga tcgctttcat attgtacaac atcttagccg tgcta                   285

<210>   1660
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase-related

<400>   1660
Met Ser Phe Ile Ala Gln Asp Phe Asp Lys Leu Asp Ile Ile Thr Val 
1               5                   10                  15      

Leu Glu Gly Arg Thr Gln Ala Ile Ile Arg Asp His Phe Leu Lys Tyr 
            20                  25                  30          

Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile Thr Met Asp Met Phe 
        35                  40                  45              

Ser Pro Tyr Tyr Asp Leu Ala Arg Gln Leu Arg Phe Gln Ile Ser Arg 
    50                  55                  60                  

Leu Arg Leu Lys Gln Ser Pro Arg Leu Phe His Ser Arg Met Leu Lys 
65                  70                  75                  80  

Ser Phe Leu Ile Ala Phe Ile Leu Tyr Asn Ile Leu Ala Val Leu 
                85                  90                  95  

<210>   1661
<211>   510
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1661
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatca tcaataaaga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accgtctaag   180
attccttacc ttgagacaac tggtatgcct actagaattc tacttagaaa gcgtcgtttc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ctatcgtcaa gaaaaatcac   300
caaattcctc gtattatcaa ccaaaaaatt gcgcaaaagt tgattgagaa gatttctatg   360
accgatattg ctcatcagct ggccatttca acttcaactg tcattcgaaa gctcaatgat   420
tctcactttg agcatgattt ttcgcgtctt cctgagatta tgtcctggga cgttgaaaca   480
gtccggggag tgactgtttc aatcgggaga                                    510

<210>   1662
<211>   170
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   1662
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ala 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Ser His Phe Glu 
    130                 135                 140                 

His Asp Phe Ser Arg Leu Pro Glu Ile Met Ser Trp Asp Val Glu Thr 
145                 150                 155                 160 

Val Arg Gly Val Thr Val Ser Ile Gly Arg 
                165                 170 

<210>   1663
<211>   495
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1663
atgttaaaat cagaaaaaca atcacgttat caaatgttaa atgaagaatt gtccttccta   60
ttggaaggcg aaaccaatgt tttggctaat ctttccaacg ccagtgctct cataaaatca   120
cgttttccta ataccgtatt tgcaggcttt tatttgttcg atggaaagga attggtttta   180
ggccccttcc aaggaggtgt ttcctgcatc cgtattgcac taggcaaggg tgtttgtggt   240
gaggcagctc actttcagga aactgttatt gttggagatg tgacgaccta tctcaactat   300
atttcttgtg atagtctagc taaaagtgaa attgtggtgc cgatgatgaa gaatggtcag   360
ttacttggag ttctggatct ggattcttca gagattgagg attacgatgc tatggatcga   420
gattatttgg aacaatttgt cgctattttg cttgaaaaga cagcatggga ctttacgatg   480
tttgaggaaa aatct                                                    495

<210>   1664
<211>   165
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902812 (5.E-91)

<400>   1664
Met Leu Lys Ser Glu Lys Gln Ser Arg Tyr Gln Met Leu Asn Glu Glu 
1               5                   10                  15      

Leu Ser Phe Leu Leu Glu Gly Glu Thr Asn Val Leu Ala Asn Leu Ser 
            20                  25                  30          

Asn Ala Ser Ala Leu Ile Lys Ser Arg Phe Pro Asn Thr Val Phe Ala 
        35                  40                  45              

Gly Phe Tyr Leu Phe Asp Gly Lys Glu Leu Val Leu Gly Pro Phe Gln 
    50                  55                  60                  

Gly Gly Val Ser Cys Ile Arg Ile Ala Leu Gly Lys Gly Val Cys Gly 
65                  70                  75                  80  

Glu Ala Ala His Phe Gln Glu Thr Val Ile Val Gly Asp Val Thr Thr 
                85                  90                  95      

Tyr Leu Asn Tyr Ile Ser Cys Asp Ser Leu Ala Lys Ser Glu Ile Val 
            100                 105                 110         

Val Pro Met Met Lys Asn Gly Gln Leu Leu Gly Val Leu Asp Leu Asp 
        115                 120                 125             

Ser Ser Glu Ile Glu Asp Tyr Asp Ala Met Asp Arg Asp Tyr Leu Glu 
    130                 135                 140                 

Gln Phe Val Ala Ile Leu Leu Glu Lys Thr Ala Trp Asp Phe Thr Met 
145                 150                 155                 160 

Phe Glu Glu Lys Ser 
                165 

<210>   1665
<211>   1653
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1665
atgtatcaag cactttatcg aaaatataga agtcaaaact tctcccagtt agttggtcaa   60
gaagttgtgg ctaagactct taaacaagcg gtggagcaag agaaaataag tcacgcttat   120
cttttttctg gtcctcgtgg aacgggaaaa accagtgttg ctaaaatctt tgccaaggct   180
atgaactgtc ccaatcaagt gggtggcgaa ccttgcaata actgctatat ttgtcaagca   240
gtgacggacg gtagtttaga agatgtcatt gaaatggatg cagcttctaa taatggggta   300
gatgaaattc gcgaaattcg tgataaatct acctatgcgc ctagccttgc tcgttataag   360
gtttatatca tagatgaggt tcacatgctg tctacagggg cttttaatgc cctcctaaag   420
acgctggaag aaccaacaca gaatgtagtc tttattttgg ccactactga attgcacaag   480
attcctgcta ctattctatc ccgtgtgcaa cgttttgagt ttaaatcaat taagacacag   540
gatattaagg aacatattca ctatatctta gaaaaagaaa atatcagttc tgaaccagag   600
gctgtggaaa tcattgccag acgggcggaa ggtggaatgc gggacgcctt gtctattttg   660
gatcaagccc tgagtttgac acagggaaat gagctgacga ctgctatctc tgaagaaatt   720
actggcacca ttagcctatc agccttggat gattatgtgg cggccttgtc tcaacaggat   780
gttcccaaag ctttgtcttg cttgaatctt ctttttgaca atggtaagag catgactcgt   840
tttgtgaccg atcttttgca ctatttaaga gacttgttaa ttgttcaaac agggggagca   900
aatactcatc atagttcagt ctttgtagaa aatttggcac ttcctcaaaa aaatctgttt   960
gaaatgattc gcttagcaac agtgagttta gcagatatta agtctagttt gcaacccaag   1020
atttatgctg aaatgatgac cgtccgtttg gcggaaatca agtccgaacc agctctatca   1080
ggagcggttg aaaatgaaat tgctacgctg agacaggaag ttgcccgtct caaacaagag   1140
ctttctaatg taggtgcggt tcctaaacaa gttgcaccag ctcctagtcg accagctacg   1200
ggcaaaacag tctatcgtgt cgatcgcaat aaagtgcaat ctatcttaca agaggccgtc   1260
gaaaatcctg atttagcacg tcaaaattta attcgtttgc agaatgcctg gggagaggta   1320
attgaaagtc taggtgggcc ggacaaggct ctgctagttg gttctcaacc ggttgctgcc   1380
aatgaacacc atgctattct tgcttttgag tctaacttca atgctggtca aactatgaaa   1440
cgagacaatc tcaataccat gtttggtaat atcctcagtc aggcggcagg tttttcacct   1500
gagattttag ctatttccat ggaggaatgg aaagaagttc gcgcagcctt ttcagccaaa   1560
gccaaatctt ctcaaactga aaaagaagta gaagaaagcc tgattccaga aggatttgaa   1620
tttttggctg ataaagtgaa ggtagaggaa gac                                1653

<210>   1666
<211>   551
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   DNA polymerase III, gamma and tau subunits (dnaX)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902813 (0.E+01)

<400>   1666
Met Tyr Gln Ala Leu Tyr Arg Lys Tyr Arg Ser Gln Asn Phe Ser Gln 
1               5                   10                  15      

Leu Val Gly Gln Glu Val Val Ala Lys Thr Leu Lys Gln Ala Val Glu 
            20                  25                  30          

Gln Glu Lys Ile Ser His Ala Tyr Leu Phe Ser Gly Pro Arg Gly Thr 
        35                  40                  45              

Gly Lys Thr Ser Val Ala Lys Ile Phe Ala Lys Ala Met Asn Cys Pro 
    50                  55                  60                  

Asn Gln Val Gly Gly Glu Pro Cys Asn Asn Cys Tyr Ile Cys Gln Ala 
65                  70                  75                  80  

Val Thr Asp Gly Ser Leu Glu Asp Val Ile Glu Met Asp Ala Ala Ser 
                85                  90                  95      

Asn Asn Gly Val Asp Glu Ile Arg Glu Ile Arg Asp Lys Ser Thr Tyr 
            100                 105                 110         

Ala Pro Ser Leu Ala Arg Tyr Lys Val Tyr Ile Ile Asp Glu Val His 
        115                 120                 125             

Met Leu Ser Thr Gly Ala Phe Asn Ala Leu Leu Lys Thr Leu Glu Glu 
    130                 135                 140                 

Pro Thr Gln Asn Val Val Phe Ile Leu Ala Thr Thr Glu Leu His Lys 
145                 150                 155                 160 

Ile Pro Ala Thr Ile Leu Ser Arg Val Gln Arg Phe Glu Phe Lys Ser 
                165                 170                 175     

Ile Lys Thr Gln Asp Ile Lys Glu His Ile His Tyr Ile Leu Glu Lys 
            180                 185                 190         

Glu Asn Ile Ser Ser Glu Pro Glu Ala Val Glu Ile Ile Ala Arg Arg 
        195                 200                 205             

Ala Glu Gly Gly Met Arg Asp Ala Leu Ser Ile Leu Asp Gln Ala Leu 
    210                 215                 220                 

Ser Leu Thr Gln Gly Asn Glu Leu Thr Thr Ala Ile Ser Glu Glu Ile 
225                 230                 235                 240 

Thr Gly Thr Ile Ser Leu Ser Ala Leu Asp Asp Tyr Val Ala Ala Leu 
                245                 250                 255     

Ser Gln Gln Asp Val Pro Lys Ala Leu Ser Cys Leu Asn Leu Leu Phe 
            260                 265                 270         

Asp Asn Gly Lys Ser Met Thr Arg Phe Val Thr Asp Leu Leu His Tyr 
        275                 280                 285             

Leu Arg Asp Leu Leu Ile Val Gln Thr Gly Gly Ala Asn Thr His His 
    290                 295                 300                 

Ser Ser Val Phe Val Glu Asn Leu Ala Leu Pro Gln Lys Asn Leu Phe 
305                 310                 315                 320 

Glu Met Ile Arg Leu Ala Thr Val Ser Leu Ala Asp Ile Lys Ser Ser 
                325                 330                 335     

Leu Gln Pro Lys Ile Tyr Ala Glu Met Met Thr Val Arg Leu Ala Glu 
            340                 345                 350         

Ile Lys Ser Glu Pro Ala Leu Ser Gly Ala Val Glu Asn Glu Ile Ala 
        355                 360                 365             

Thr Leu Arg Gln Glu Val Ala Arg Leu Lys Gln Glu Leu Ser Asn Val 
    370                 375                 380                 

Gly Ala Val Pro Lys Gln Val Ala Pro Ala Pro Ser Arg Pro Ala Thr 
385                 390                 395                 400 

Gly Lys Thr Val Tyr Arg Val Asp Arg Asn Lys Val Gln Ser Ile Leu 
                405                 410                 415     

Gln Glu Ala Val Glu Asn Pro Asp Leu Ala Arg Gln Asn Leu Ile Arg 
            420                 425                 430         

Leu Gln Asn Ala Trp Gly Glu Val Ile Glu Ser Leu Gly Gly Pro Asp 
        435                 440                 445             

Lys Ala Leu Leu Val Gly Ser Gln Pro Val Ala Ala Asn Glu His His 
    450                 455                 460                 

Ala Ile Leu Ala Phe Glu Ser Asn Phe Asn Ala Gly Gln Thr Met Lys 
465                 470                 475                 480 

Arg Asp Asn Leu Asn Thr Met Phe Gly Asn Ile Leu Ser Gln Ala Ala 
                485                 490                 495     

Gly Phe Ser Pro Glu Ile Leu Ala Ile Ser Met Glu Glu Trp Lys Glu 
            500                 505                 510         

Val Arg Ala Ala Phe Ser Ala Lys Ala Lys Ser Ser Gln Thr Glu Lys 
        515                 520                 525             

Glu Val Glu Glu Ser Leu Ile Pro Glu Gly Phe Glu Phe Leu Ala Asp 
    530                 535                 540                 

Lys Val Lys Val Glu Glu Asp 
545                 550     

<210>   1667
<211>   192
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1667
atgaataaac aacaatttat tattatggcg ctgtttacag ctgctgagac ctattttttc   60
aatgaagcct ggatgactgg ccgctatatt atggcagcct tttgggcaat tttactcttt   120
agaaatttcc gagtcagtta tgtgatgggc aaaatcgttg atgtcatcga tcagcatttt   180
aataggaaag ac                                                       192

<210>   1668
<211>   64
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902814 (6.E-34)

<400>   1668
Met Asn Lys Gln Gln Phe Ile Ile Met Ala Leu Phe Thr Ala Ala Glu 
1               5                   10                  15      

Thr Tyr Phe Phe Asn Glu Ala Trp Met Thr Gly Arg Tyr Ile Met Ala 
            20                  25                  30          

Ala Phe Trp Ala Ile Leu Leu Phe Arg Asn Phe Arg Val Ser Tyr Val 
        35                  40                  45              

Met Gly Lys Ile Val Asp Val Ile Asp Gln His Phe Asn Arg Lys Asp 
    50                  55                  60                  


<210>   1669
<211>   789
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1669
ttgaaaaaga aaggaactat catgtcagta ttagagatca aagatcttca cgttgagatt   60
gaaggaaaag aaattttaaa aggggttaac ctgaccctga aaacaggaga aattgccgct   120
atcatgggac caaatggtac aggtaaatcg actctttctg ccgctatcat gggaaatcca   180
aactatgaag taactaaagg tgaagttttg tttgatggcg taaacatcct tgagttggaa   240
gtggatgagc gtgcgcgtat gggacttttc cttgctatgc aatacccatc agaaatccct   300
ggaattacca atgctgagtt tcttcgtgcc gctatgaatg cgggtaaaga agatgatgag   360
aagatttcag ttcgtgagtt tattactaag ctagatgaaa aaatggaatt gctcaacatg   420
aaagaagaaa tggcagagcg ttacctcaac gaaggcttct ctggtggtga gaaaaaacgc   480
aatgaaattc ttcaactttt gatgttggag ccaacatttg ctcttttgga cgagattgac   540
tcaggtcttg atattgacgc tcttaaagtt gtgtctaaag gtgtcaatgc catgcgtggt   600
gaaggttttg gtgctatgat catcactcac taccaacgtc ttttgaacta tatcacacct   660
gatgtggtac acgtgatgat ggaaggtcgt gttgtccttt ctggtggtcc agaattggct   720
gcgcgtttgg aacgtgaagg atacgcaaaa ttagctgaag aacttggcta cgactacaag   780
gaagaattg                                                           789

<210>   1670
<211>   263
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902815 (e-142)

<400>   1670
Met Lys Lys Lys Gly Thr Ile Met Ser Val Leu Glu Ile Lys Asp Leu 
1               5                   10                  15      

His Val Glu Ile Glu Gly Lys Glu Ile Leu Lys Gly Val Asn Leu Thr 
            20                  25                  30          

Leu Lys Thr Gly Glu Ile Ala Ala Ile Met Gly Pro Asn Gly Thr Gly 
        35                  40                  45              

Lys Ser Thr Leu Ser Ala Ala Ile Met Gly Asn Pro Asn Tyr Glu Val 
    50                  55                  60                  

Thr Lys Gly Glu Val Leu Phe Asp Gly Val Asn Ile Leu Glu Leu Glu 
65                  70                  75                  80  

Val Asp Glu Arg Ala Arg Met Gly Leu Phe Leu Ala Met Gln Tyr Pro 
                85                  90                  95      

Ser Glu Ile Pro Gly Ile Thr Asn Ala Glu Phe Leu Arg Ala Ala Met 
            100                 105                 110         


Asn Ala Gly Lys Glu Asp Asp Glu Lys Ile Ser Val Arg Glu Phe Ile 
        115                 120                 125             

Thr Lys Leu Asp Glu Lys Met Glu Leu Leu Asn Met Lys Glu Glu Met 
    130                 135                 140                 

Ala Glu Arg Tyr Leu Asn Glu Gly Phe Ser Gly Gly Glu Lys Lys Arg 
145                 150                 155                 160 

Asn Glu Ile Leu Gln Leu Leu Met Leu Glu Pro Thr Phe Ala Leu Leu 
                165                 170                 175     

Asp Glu Ile Asp Ser Gly Leu Asp Ile Asp Ala Leu Lys Val Val Ser 
            180                 185                 190         

Lys Gly Val Asn Ala Met Arg Gly Glu Gly Phe Gly Ala Met Ile Ile 
        195                 200                 205             

Thr His Tyr Gln Arg Leu Leu Asn Tyr Ile Thr Pro Asp Val Val His 
    210                 215                 220                 

Val Met Met Glu Gly Arg Val Val Leu Ser Gly Gly Pro Glu Leu Ala 
225                 230                 235                 240 

Ala Arg Leu Glu Arg Glu Gly Tyr Ala Lys Leu Ala Glu Glu Leu Gly 
                245                 250                 255     

Tyr Asp Tyr Lys Glu Glu Leu 
            260             

<210>   1671
<211>   1260
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1671
atgactagag aaaatattaa acttttttca gaaatgcacg ctgaaccaag ctggttggct   60
gatctccgtc aaaaagcttt tgacaagatt gagactttgg aattaccagt tattgagtgt   120
gtcaaattcc accgttggaa tctgggtgat ggaacgatta cagaaaatga gccatcagca   180
aatgttccag atttcacagc tttagatcat cacttgaagt tggtgcaagt aggaactcaa   240
actgttttcg aacaaactcc agttgagtta gctgaacagg gtgttgtctt cacagacttt   300
cactcagctt tagaagaaat tccagagctg atcgaagaat tcttcatgtc atctgttaag   360
tatgatgatg acaagttggc ggcttaccac acagcttact ttaacagtgg tgctgtactc   420
tatattccag ataacgtaga aatcacagag ccaattgaag gaattttcta ccaagatagc   480
gatagcaatg tgccgtttaa caagcatatt atgattatcg ttggtaaaaa ttctaagatt   540
agttatctgg agcgtttaga gtcacgcggt gaaggaagtg acaaagcaac tgccaatatc   600
acagtggaag tgattgcacg ttctggtgcg caagtcaagt ttgctgctat cgaccgtcta   660
ggtgaaaacg tcactgccta cattagccgt cgtggtaaat taggcaacga tgcaagtatt   720
gactgggcta tcggtgtcat gaacgaagga aatgtcgttg ctgattttga tagtgacttg   780
attggtaatg gtagccatgc tgacctcaag gttgtagctc tttcaagtgg tcgtcaggta   840
caagggattg atactcgtgt aactaactat ggctgcaact caatcggaaa cattctacaa   900
catggggtta tccttgaaaa agcaactttg actttcaatg gtatcggcca catcatcaag   960
ggtgctaagg gagcagatgc gcaacaagag agccgtgttc tcatgctttc agaccaagcg   1020
cgttcagatg ctaacccaat tcttttgatt gatgaaaatg acgtaactgc aggccatgca   1080
gcctctattg gtcaggtaga tccagaagat atgtactacc tcatgagtcg tggcttggat   1140
aaggcaactg cagagcgttt ggttgttcgt ggtttccttg gatctgttat cgtggagatt   1200
ccagtcaagg aagttcgtga tgaaatgatt gcaactatcg aagagaaatt gtcaaaacgc   1260

<210>   1672
<211>   420
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902816 (0.E+01)

<400>   1672
Met Thr Arg Glu Asn Ile Lys Leu Phe Ser Glu Met His Ala Glu Pro 
1               5                   10                  15      

Ser Trp Leu Ala Asp Leu Arg Gln Lys Ala Phe Asp Lys Ile Glu Thr 
            20                  25                  30          

Leu Glu Leu Pro Val Ile Glu Cys Val Lys Phe His Arg Trp Asn Leu 
        35                  40                  45              

Gly Asp Gly Thr Ile Thr Glu Asn Glu Pro Ser Ala Asn Val Pro Asp 
    50                  55                  60                  

Phe Thr Ala Leu Asp His His Leu Lys Leu Val Gln Val Gly Thr Gln 
65                  70                  75                  80  

Thr Val Phe Glu Gln Thr Pro Val Glu Leu Ala Glu Gln Gly Val Val 
                85                  90                  95      

Phe Thr Asp Phe His Ser Ala Leu Glu Glu Ile Pro Glu Leu Ile Glu 
            100                 105                 110         

Glu Phe Phe Met Ser Ser Val Lys Tyr Asp Asp Asp Lys Leu Ala Ala 
        115                 120                 125             

Tyr His Thr Ala Tyr Phe Asn Ser Gly Ala Val Leu Tyr Ile Pro Asp 
    130                 135                 140                 

Asn Val Glu Ile Thr Glu Pro Ile Glu Gly Ile Phe Tyr Gln Asp Ser 
145                 150                 155                 160 

Asp Ser Asn Val Pro Phe Asn Lys His Ile Met Ile Ile Val Gly Lys 
                165                 170                 175     

Asn Ser Lys Ile Ser Tyr Leu Glu Arg Leu Glu Ser Arg Gly Glu Gly 
            180                 185                 190         

Ser Asp Lys Ala Thr Ala Asn Ile Thr Val Glu Val Ile Ala Arg Ser 
        195                 200                 205             

Gly Ala Gln Val Lys Phe Ala Ala Ile Asp Arg Leu Gly Glu Asn Val 
    210                 215                 220                 

Thr Ala Tyr Ile Ser Arg Arg Gly Lys Leu Gly Asn Asp Ala Ser Ile 
225                 230                 235                 240 

Asp Trp Ala Ile Gly Val Met Asn Glu Gly Asn Val Val Ala Asp Phe 
                245                 250                 255     

Asp Ser Asp Leu Ile Gly Asn Gly Ser His Ala Asp Leu Lys Val Val 
            260                 265                 270         

Ala Leu Ser Ser Gly Arg Gln Val Gln Gly Ile Asp Thr Arg Val Thr 
        275                 280                 285             

Asn Tyr Gly Cys Asn Ser Ile Gly Asn Ile Leu Gln His Gly Val Ile 
    290                 295                 300                 

Leu Glu Lys Ala Thr Leu Thr Phe Asn Gly Ile Gly His Ile Ile Lys 
305                 310                 315                 320 

Gly Ala Lys Gly Ala Asp Ala Gln Gln Glu Ser Arg Val Leu Met Leu 
                325                 330                 335     

Ser Asp Gln Ala Arg Ser Asp Ala Asn Pro Ile Leu Leu Ile Asp Glu 
            340                 345                 350         

Asn Asp Val Thr Ala Gly His Ala Ala Ser Ile Gly Gln Val Asp Pro 
        355                 360                 365             

Glu Asp Met Tyr Tyr Leu Met Ser Arg Gly Leu Asp Lys Ala Thr Ala 
    370                 375                 380                 

Glu Arg Leu Val Val Arg Gly Phe Leu Gly Ser Val Ile Val Glu Ile 
385                 390                 395                 400 

Pro Val Lys Glu Val Arg Asp Glu Met Ile Ala Thr Ile Glu Glu Lys 
                405                 410                 415     

Leu Ser Lys Arg 
            420 

<210>   1673
<211>   1224
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1673
atgttagatg tagaagcgat tcgcaaggat tttccaattt tagatcagat tgtcaatgat   60
gaacctctgg tctatctgga caatgctgcg acgacacaaa aaccactagt agttctgaaa   120
gctattaaca gctactatga gcaggacaat gccaatgttc accgtggtgt ccatacctta   180
gcggaacgag cgacagcttc ttatgaagct gctcgtgaaa ccattcgtaa gtttattaat   240
gcaggctcta caaaggaagt tctctttacc agaggaacga caaccagcct taactgggtg   300
gcacgctttg ctgaggaaat tctcactgag ggagaccagg tcttgatttc agtaatggaa   360
caccattcta atatcattcc atggcaggaa gcttgtcgaa agactggagc agagcttgtc   420
tatgtctatc ttaaagacgg tgccttggat atggaggatt tgcgagctaa attgactgat   480
aaggttaaat ttgtttccct agctcatgcc tccaatgttc ttggtgtggt caatccgatc   540
aaggaaatca ctcaattagc ccaccaagtt ggggcaatta tggtagtgga tggtgctcaa   600
tctacacctc atatgaagat tgatgtccag gacttggatc tggacttttt cgccttttcg   660
ggtcacaaga tggctggtcc gactggtatc ggtgtccttt acggcaaaga aaagtatctt   720
gagcaaatgt ctccagtaga atttggcggc gagatgattg attttgtcta cgagcaattt   780
gctagttgga aggaattgcc ttggaaattt gaggctggaa cgccaaatat ggcaggagct   840
attggacttg cgactgcagt tgattatctg gaaaagattg gtatggatgc cgttgaagct   900
catgaacagg aattgattgc gtacgtctat ccaaaactgc aggcaattga gggattgacc   960
atttacggtt ctcaggattt ggctcaacgt tcgggtgtta ttgcctttaa cctaggtgat   1020
ctccatcctc acgatcttgc gacggctctg gattatgaag gagtggctgt tcgtgctggt   1080
caccattgtg cgcaaccctt gcttcagtat ttggaagtcc cagcaacagc tcgtgcaagt   1140
ttttatatct acaataccaa ggcagattgc gacaaactag tcgatgccct acaaaagaca   1200
aaggagtttt tcaatggcac tttc                                          1224

<210>   1674
<211>   408
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aminotransferase, class-V
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902817 (0.E+01)

<400>   1674
Met Leu Asp Val Glu Ala Ile Arg Lys Asp Phe Pro Ile Leu Asp Gln 
1               5                   10                  15      

Ile Val Asn Asp Glu Pro Leu Val Tyr Leu Asp Asn Ala Ala Thr Thr 
            20                  25                  30          

Gln Lys Pro Leu Val Val Leu Lys Ala Ile Asn Ser Tyr Tyr Glu Gln 
        35                  40                  45              

Asp Asn Ala Asn Val His Arg Gly Val His Thr Leu Ala Glu Arg Ala 
    50                  55                  60                  

Thr Ala Ser Tyr Glu Ala Ala Arg Glu Thr Ile Arg Lys Phe Ile Asn 
65                  70                  75                  80  

Ala Gly Ser Thr Lys Glu Val Leu Phe Thr Arg Gly Thr Thr Thr Ser 
                85                  90                  95      

Leu Asn Trp Val Ala Arg Phe Ala Glu Glu Ile Leu Thr Glu Gly Asp 
            100                 105                 110         

Gln Val Leu Ile Ser Val Met Glu His His Ser Asn Ile Ile Pro Trp 
        115                 120                 125             

Gln Glu Ala Cys Arg Lys Thr Gly Ala Glu Leu Val Tyr Val Tyr Leu 
    130                 135                 140                 

Lys Asp Gly Ala Leu Asp Met Glu Asp Leu Arg Ala Lys Leu Thr Asp 
145                 150                 155                 160 

Lys Val Lys Phe Val Ser Leu Ala His Ala Ser Asn Val Leu Gly Val 
                165                 170                 175     

Val Asn Pro Ile Lys Glu Ile Thr Gln Leu Ala His Gln Val Gly Ala 
            180                 185                 190         

Ile Met Val Val Asp Gly Ala Gln Ser Thr Pro His Met Lys Ile Asp 
        195                 200                 205             

Val Gln Asp Leu Asp Leu Asp Phe Phe Ala Phe Ser Gly His Lys Met 
    210                 215                 220                 

Ala Gly Pro Thr Gly Ile Gly Val Leu Tyr Gly Lys Glu Lys Tyr Leu 
225                 230                 235                 240 

Glu Gln Met Ser Pro Val Glu Phe Gly Gly Glu Met Ile Asp Phe Val 
                245                 250                 255     

Tyr Glu Gln Phe Ala Ser Trp Lys Glu Leu Pro Trp Lys Phe Glu Ala 
            260                 265                 270         

Gly Thr Pro Asn Met Ala Gly Ala Ile Gly Leu Ala Thr Ala Val Asp 
        275                 280                 285             

Tyr Leu Glu Lys Ile Gly Met Asp Ala Val Glu Ala His Glu Gln Glu 
    290                 295                 300                 

Leu Ile Ala Tyr Val Tyr Pro Lys Leu Gln Ala Ile Glu Gly Leu Thr 
305                 310                 315                 320 

Ile Tyr Gly Ser Gln Asp Leu Ala Gln Arg Ser Gly Val Ile Ala Phe 
                325                 330                 335     

Asn Leu Gly Asp Leu His Pro His Asp Leu Ala Thr Ala Leu Asp Tyr 
            340                 345                 350         

Glu Gly Val Ala Val Arg Ala Gly His His Cys Ala Gln Pro Leu Leu 
        355                 360                 365             

Gln Tyr Leu Glu Val Pro Ala Thr Ala Arg Ala Ser Phe Tyr Ile Tyr 
    370                 375                 380                 

Asn Thr Lys Ala Asp Cys Asp Lys Leu Val Asp Ala Leu Gln Lys Thr 
385                 390                 395                 400 

Lys Glu Phe Phe Asn Gly Thr Phe 
                405             

<210>   1675
<211>   438
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1675
atggcacttt ctaaactaga tagcctttat atggcagtgg tagcagacca ttcgaaaaat   60
ccacatcacc aagggaagtt agaagatgct gagcaaatca gtctcaacaa tccgacttgt   120
ggggatgtca tcaacctctc tgtcaagttt gatgcagagg accgtttgga agatattgct   180
tttctaaatt caggatgcac gatttcaact gcttctgcta gtatgatgac agatgccgtt   240
ttaggaaaaa ccaaacaaga aattttagaa ctggcgacta ttttttctga aatggttcaa   300
gggcaaaaag atgagcgtca agaccaactt ggagacgcgg cattcttgtc aggtgttgcc   360
aaattccctc aaagaatcaa gtgtgcaacc ctagcttgga atgcccttaa gaaaacaatt   420
gaaaatcaag aaaaacag                                                 438

<210>   1676
<211>   146
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   NifU family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902818 (2.E-79)

<400>   1676
Met Ala Leu Ser Lys Leu Asp Ser Leu Tyr Met Ala Val Val Ala Asp 
1               5                   10                  15      

His Ser Lys Asn Pro His His Gln Gly Lys Leu Glu Asp Ala Glu Gln 
            20                  25                  30          

Ile Ser Leu Asn Asn Pro Thr Cys Gly Asp Val Ile Asn Leu Ser Val 
        35                  40                  45              

Lys Phe Asp Ala Glu Asp Arg Leu Glu Asp Ile Ala Phe Leu Asn Ser 
    50                  55                  60                  

Gly Cys Thr Ile Ser Thr Ala Ser Ala Ser Met Met Thr Asp Ala Val 
65                  70                  75                  80  

Leu Gly Lys Thr Lys Gln Glu Ile Leu Glu Leu Ala Thr Ile Phe Ser 
                85                  90                  95      

Glu Met Val Gln Gly Gln Lys Asp Glu Arg Gln Asp Gln Leu Gly Asp 
            100                 105                 110         

Ala Ala Phe Leu Ser Gly Val Ala Lys Phe Pro Gln Arg Ile Lys Cys 
        115                 120                 125             

Ala Thr Leu Ala Trp Asn Ala Leu Lys Lys Thr Ile Glu Asn Gln Glu 
    130                 135                 140                 

Lys Gln 
145     

<210>   1677
<211>   1410
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1677
atggctgaag aaagagtaga accaaaacca attgaccttg gtgaatataa atttggtttc   60
catgacgatg tagagcctgt cttatcgaca ggaaaaggac tcaacgaagg tgttattcgt   120
gaattatctg ctgctaaggg tgagcctgag tggatgttgg agttccgttt gaagtcttat   180
gaaaccttca aaaaaatgcc catgcaaact tggggagcag acttgtcaga gattgacttt   240
gatgacttaa tctactacca aaaaccatct gacaaaccag cccgttcttg ggatgatgta   300
cctgaaaaga ttaaagaaac ctttgaacgt atcgggattc cagaagctga acgtgcttat   360
ttagcagggg cttctgccca gtacgagtca gaagtggttt accacaacat gaaggaagag   420
ttccaaaaat taggtattat ctttacagat acagattccg cactcaagga atacccagac   480
ttatttaaac aatactttgc gaagttggta ccgccgacag ataacaagtt ggcagccctc   540
aactcagcag tatggtcggg tggaactttt atctacgtgc caaaaggtgt caaggtagat   600
attccacttc aaacttattt ccgtatcaat aacgaaaata taggtcagtt cgaacgtacc   660
ttgattatcg ttgatgaggg agcaagcgtc tactacgtag aaggatgtac agcaccaaca   720
tattcaagca atagcttaca cgctgccatt gtagaaattt ttgctttgga cggagcttat   780
atgcgttata caactatcca aaactggtct gataacgtct ataacttggt aacaaagcgt   840
gctaaggctc aaaaggatgc cactgttgag tggattgatg gaaacttggg tgccaaaacg   900
actatgaaat atccatctgt ttaccttgat ggagaaggag cgcgtggtac catgctctct   960
atcgcctttg ctaatgcagg gcaacaccaa gacacgggtg ctaagatgat tcacaatgct   1020
ccacatacca gctcgtctat tgtgtctaaa tccatcgcta aaggtggagg aaaggttgac   1080
taccgtggac aagtcacctt taacaagaac tctaagaaat ctgtttccca cattgaatgt   1140
gataccatta tcatggatga cttgtcagca tcagatacta ttccatttaa tgaaattcac   1200
aactcgcaag tggctttgga acacgaagcc aaagtatcta agatttcaga agagcaattg   1260
tattatctca tgagccgtgg attgtcagaa tctgaggcaa ctgaaatgat tgtcatggga   1320
tttgtagaac cctttacaaa agaacttcca atggaatacg cagttgagct gaaccgcttg   1380
attagctatg aaatggaggg atcagttgga                                    1410

<210>   1678
<211>   470
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical intein-containing protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902819 (0.E+01)

<400>   1678
Met Ala Glu Glu Arg Val Glu Pro Lys Pro Ile Asp Leu Gly Glu Tyr 
1               5                   10                  15      

Lys Phe Gly Phe His Asp Asp Val Glu Pro Val Leu Ser Thr Gly Lys 
            20                  25                  30          

Gly Leu Asn Glu Gly Val Ile Arg Glu Leu Ser Ala Ala Lys Gly Glu 
        35                  40                  45              

Pro Glu Trp Met Leu Glu Phe Arg Leu Lys Ser Tyr Glu Thr Phe Lys 
    50                  55                  60                  

Lys Met Pro Met Gln Thr Trp Gly Ala Asp Leu Ser Glu Ile Asp Phe 
65                  70                  75                  80  

Asp Asp Leu Ile Tyr Tyr Gln Lys Pro Ser Asp Lys Pro Ala Arg Ser 
                85                  90                  95      

Trp Asp Asp Val Pro Glu Lys Ile Lys Glu Thr Phe Glu Arg Ile Gly 
            100                 105                 110         

Ile Pro Glu Ala Glu Arg Ala Tyr Leu Ala Gly Ala Ser Ala Gln Tyr 
        115                 120                 125             

Glu Ser Glu Val Val Tyr His Asn Met Lys Glu Glu Phe Gln Lys Leu 
    130                 135                 140                 

Gly Ile Ile Phe Thr Asp Thr Asp Ser Ala Leu Lys Glu Tyr Pro Asp 
145                 150                 155                 160 

Leu Phe Lys Gln Tyr Phe Ala Lys Leu Val Pro Pro Thr Asp Asn Lys 
                165                 170                 175     

Leu Ala Ala Leu Asn Ser Ala Val Trp Ser Gly Gly Thr Phe Ile Tyr 
            180                 185                 190         

Val Pro Lys Gly Val Lys Val Asp Ile Pro Leu Gln Thr Tyr Phe Arg 
        195                 200                 205             

Ile Asn Asn Glu Asn Ile Gly Gln Phe Glu Arg Thr Leu Ile Ile Val 
    210                 215                 220                 

Asp Glu Gly Ala Ser Val Tyr Tyr Val Glu Gly Cys Thr Ala Pro Thr 
225                 230                 235                 240 

Tyr Ser Ser Asn Ser Leu His Ala Ala Ile Val Glu Ile Phe Ala Leu 
                245                 250                 255     

Asp Gly Ala Tyr Met Arg Tyr Thr Thr Ile Gln Asn Trp Ser Asp Asn 
            260                 265                 270         

Val Tyr Asn Leu Val Thr Lys Arg Ala Lys Ala Gln Lys Asp Ala Thr 
        275                 280                 285             

Val Glu Trp Ile Asp Gly Asn Leu Gly Ala Lys Thr Thr Met Lys Tyr 
    290                 295                 300                 

Pro Ser Val Tyr Leu Asp Gly Glu Gly Ala Arg Gly Thr Met Leu Ser 
305                 310                 315                 320 

Ile Ala Phe Ala Asn Ala Gly Gln His Gln Asp Thr Gly Ala Lys Met 
                325                 330                 335     

Ile His Asn Ala Pro His Thr Ser Ser Ser Ile Val Ser Lys Ser Ile 
            340                 345                 350         

Ala Lys Gly Gly Gly Lys Val Asp Tyr Arg Gly Gln Val Thr Phe Asn 
        355                 360                 365             

Lys Asn Ser Lys Lys Ser Val Ser His Ile Glu Cys Asp Thr Ile Ile 
    370                 375                 380                 

Met Asp Asp Leu Ser Ala Ser Asp Thr Ile Pro Phe Asn Glu Ile His 
385                 390                 395                 400 

Asn Ser Gln Val Ala Leu Glu His Glu Ala Lys Val Ser Lys Ile Ser 
                405                 410                 415     

Glu Glu Gln Leu Tyr Tyr Leu Met Ser Arg Gly Leu Ser Glu Ser Glu 
            420                 425                 430         

Ala Thr Glu Met Ile Val Met Gly Phe Val Glu Pro Phe Thr Lys Glu 
        435                 440                 445             

Leu Pro Met Glu Tyr Ala Val Glu Leu Asn Arg Leu Ile Ser Tyr Glu 
    450                 455                 460                 

Met Glu Gly Ser Val Gly 
465                 470 

<210>   1679
<211>   180
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1679
ttgattttat actcttcgaa aatctcttca aaccacgtca gcatcgcctt accgtatgta   60
tggttactga cttcgtcagt ttcatctaca acctcaaaac agtgttttga gcaacctgcg   120
gctagcttcc tagtttgttc tttgattttg agtattagat ttactcaaaa tcaaggattt   180

<210>   1680
<211>   60
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1680
Met Ile Leu Tyr Ser Ser Lys Ile Ser Ser Asn His Val Ser Ile Ala 
1               5                   10                  15      

Leu Pro Tyr Val Trp Leu Leu Thr Ser Ser Val Ser Ser Thr Thr Ser 
            20                  25                  30          

Lys Gln Cys Phe Glu Gln Pro Ala Ala Ser Phe Leu Val Cys Ser Leu 
        35                  40                  45              

Ile Leu Ser Ile Arg Phe Thr Gln Asn Gln Gly Phe 
    50                  55                  60  

<210>   1681
<211>   1239
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1681
atgaaaaaaa tatttttaac tttgttaact gtctctcttt tagggggtgc ttctactgct   60
gttgctcaag attttaccat tgccgctaaa catgcgattg ctgttgaggc aaatactggt   120
aaaattctct atgagaagga tgcaacgcaa cctgtcgaaa ttgcttccat aacaaaattg   180
attactgttt atctggtcta tgaagctttg gaaaacggaa gtattaccct ctccactcct   240
gtagatattt ctgattatcc ttatcaattg acgacaaatt ctgaagccag taatattcct   300
atggaggccc gtaattatac tgtcgaagag ttgcttgaag caactctggt atctagtgcc   360
aacagcgccg ctattgccct agctgagaaa attgctggct cagaaaaaga tttcgtcgat   420
atgatgcggg caaaactctt ggaatgggga attcaggatg ccactgttgt caatacgaca   480
ggtcttaaca atgaaactct aggggataac atttacccag gttctaaaaa agatgaggaa   540
aataagctta gtgcttatga tgtcgctatc gttgctcgca acctcatcaa aaaataccca   600
caagtcttag aaatcaccaa aaaaccttct tctacttttg ctgggatgac aatcacttca   660
accaactaca tgttagaagg tatgcctgct taccgtggtg gttttgatgg gctaaaaaca   720
ggaacaacag ataaggctgg agagtctttt gttggtacta ctgtcgaaaa aggcatgaga   780
gtcatcacag ttgttttaaa tgcagatcat caagacaata atccttacgc tcgatttaca   840
gctacatctt ccctaatgga ttatatttct tctacattta cacttcgcaa aatcgttcaa   900
caaggcgatg cctatcaaga tagcaaagcc cctgtacaag atggaaaaga agatacagta   960
actgcagtgg ctccagagga tatctatcta atcgaacgtg ttgggaatca atcttcccaa   1020
tctgttcaat tcacacctga ttccaaagca atcccagcac cacttgaagc tggaacagtg   1080
gttggccatt tgacttatga agacaaggac ttgattggtc aaggttacat caccacagag   1140
cgccctagtt tcgaaatggt agcagacaag aaaattgaaa aagccttctt cttaaaagtt   1200
tggtggaatc agtttgtccg ctttgttaac gagaaatta                          1239

<210>   1682
<211>   413
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   D-alanyl-D-alanine carboxypeptidase (dacA)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902820 (0.E+01)

<400>   1682
Met Lys Lys Ile Phe Leu Thr Leu Leu Thr Val Ser Leu Leu Gly Gly 
1               5                   10                  15      

Ala Ser Thr Ala Val Ala Gln Asp Phe Thr Ile Ala Ala Lys His Ala 
            20                  25                  30          

Ile Ala Val Glu Ala Asn Thr Gly Lys Ile Leu Tyr Glu Lys Asp Ala 
        35                  40                  45              

Thr Gln Pro Val Glu Ile Ala Ser Ile Thr Lys Leu Ile Thr Val Tyr 
    50                  55                  60                  

Leu Val Tyr Glu Ala Leu Glu Asn Gly Ser Ile Thr Leu Ser Thr Pro 
65                  70                  75                  80  

Val Asp Ile Ser Asp Tyr Pro Tyr Gln Leu Thr Thr Asn Ser Glu Ala 
                85                  90                  95      

Ser Asn Ile Pro Met Glu Ala Arg Asn Tyr Thr Val Glu Glu Leu Leu 
            100                 105                 110         

Glu Ala Thr Leu Val Ser Ser Ala Asn Ser Ala Ala Ile Ala Leu Ala 
        115                 120                 125             

Glu Lys Ile Ala Gly Ser Glu Lys Asp Phe Val Asp Met Met Arg Ala 
    130                 135                 140                 

Lys Leu Leu Glu Trp Gly Ile Gln Asp Ala Thr Val Val Asn Thr Thr 
145                 150                 155                 160 

Gly Leu Asn Asn Glu Thr Leu Gly Asp Asn Ile Tyr Pro Gly Ser Lys 
                165                 170                 175     

Lys Asp Glu Glu Asn Lys Leu Ser Ala Tyr Asp Val Ala Ile Val Ala 
            180                 185                 190         

Arg Asn Leu Ile Lys Lys Tyr Pro Gln Val Leu Glu Ile Thr Lys Lys 
        195                 200                 205             

Pro Ser Ser Thr Phe Ala Gly Met Thr Ile Thr Ser Thr Asn Tyr Met 
    210                 215                 220                 

Leu Glu Gly Met Pro Ala Tyr Arg Gly Gly Phe Asp Gly Leu Lys Thr 
225                 230                 235                 240 

Gly Thr Thr Asp Lys Ala Gly Glu Ser Phe Val Gly Thr Thr Val Glu 
                245                 250                 255     

Lys Gly Met Arg Val Ile Thr Val Val Leu Asn Ala Asp His Gln Asp 
            260                 265                 270         

Asn Asn Pro Tyr Ala Arg Phe Thr Ala Thr Ser Ser Leu Met Asp Tyr 
        275                 280                 285             

Ile Ser Ser Thr Phe Thr Leu Arg Lys Ile Val Gln Gln Gly Asp Ala 
    290                 295                 300                 

Tyr Gln Asp Ser Lys Ala Pro Val Gln Asp Gly Lys Glu Asp Thr Val 
305                 310                 315                 320 

Thr Ala Val Ala Pro Glu Asp Ile Tyr Leu Ile Glu Arg Val Gly Asn 
                325                 330                 335     

Gln Ser Ser Gln Ser Val Gln Phe Thr Pro Asp Ser Lys Ala Ile Pro 
            340                 345                 350         

Ala Pro Leu Glu Ala Gly Thr Val Val Gly His Leu Thr Tyr Glu Asp 
        355                 360                 365             

Lys Asp Leu Ile Gly Gln Gly Tyr Ile Thr Thr Glu Arg Pro Ser Phe 
    370                 375                 380                 

Glu Met Val Ala Asp Lys Lys Ile Glu Lys Ala Phe Phe Leu Lys Val 
385                 390                 395                 400 

Trp Trp Asn Gln Phe Val Arg Phe Val Asn Glu Lys Leu 
                405                 410             

<210>   1683
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1683
atgatggtta agagtaaaat ttctgtggtc caaaaaaata atttatttct acgaaacatg   60
agttacctcc cttactttat tttaccatat tttcaaaaag ct                      102

<210>   1684
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1684
Met Met Val Lys Ser Lys Ile Ser Val Val Gln Lys Asn Asn Leu Phe 
1               5                   10                  15      

Leu Arg Asn Met Ser Tyr Leu Pro Tyr Phe Ile Leu Pro Tyr Phe Gln 
            20                  25                  30          

Lys Ala 
        

<210>   1685
<211>   1029
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1685
atggggtctt tgattaaccc ttttgttagc gtgcttaata caattatgat tccattttta   60
ttagggggct ttttttatta tttgacaaac cctattgtta ctttcttaaa taaagtctgt   120
aaactcaatc gtttgcttgg tattttaatt accttgtgta ctttggtctg gggaatggtc   180
ataggtgttg tctatctctt acctattttg attaatcagt tatctagttt gattatatct   240
agtcaaacta tttatagtcg agtacaagac ttaatcatag acttatctaa ttatcctgcg   300
ctccagaatt tggatgtaga agctacaatt cagcagttaa acttatccta tgttgatatt   360
cttcaaaata tcctaaatag cgtatcaaat agtgtgggga gcgtcttgtc agctcttatc   420
agtactgttt tgattttgat tatgactcca gtttttttgg tttatttctt attagatgga   480
cataaattct tgcccatgct tgaaagaacg attctaaaga gggatcgctt gcatattgca   540
ggcttattaa agaatttaaa tgcgacgatt gctcgctata ttagtggagt ttcgattgac   600
gcaatcatta taggttgttt ggcttatatt ggctatagta ttattggttt aaaatatgct   660
ttagtttttg ccattttttc tggtgtagcc aatttaattc cttatgtggg gccaagtatt   720
ggtttgattc ctatgatcat cgcaaatata ttcactgatc cccatagact gctgattgca   780
gtgatttata tgcttgttgt tcagcaggta gatggcaata tcttatatcc tcgaatcgta   840
ggaagtgtta tgaaggttca tccaatcacg attttagttt tacttttgtt gtcaagcaat   900
atctatggtg tagttggaat gattgtcgca gtgccaacct attctatctt gaaagaaatt   960
tctaagttct tatcccattt gtatgaaaat cataaaataa tgaaagaacg agaaagagaa   1020
ttagctaag                                                           1029

<210>   1686
<211>   343
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902821 (0.E+01)

<400>   1686
Met Gly Ser Leu Ile Asn Pro Phe Val Ser Val Leu Asn Thr Ile Met 
1               5                   10                  15      

Ile Pro Phe Leu Leu Gly Gly Phe Phe Tyr Tyr Leu Thr Asn Pro Ile 
            20                  25                  30          

Val Thr Phe Leu Asn Lys Val Cys Lys Leu Asn Arg Leu Leu Gly Ile 
        35                  40                  45              

Leu Ile Thr Leu Cys Thr Leu Val Trp Gly Met Val Ile Gly Val Val 
    50                  55                  60                  

Tyr Leu Leu Pro Ile Leu Ile Asn Gln Leu Ser Ser Leu Ile Ile Ser 
65                  70                  75                  80  

Ser Gln Thr Ile Tyr Ser Arg Val Gln Asp Leu Ile Ile Asp Leu Ser 
                85                  90                  95      

Asn Tyr Pro Ala Leu Gln Asn Leu Asp Val Glu Ala Thr Ile Gln Gln 
            100                 105                 110         

Leu Asn Leu Ser Tyr Val Asp Ile Leu Gln Asn Ile Leu Asn Ser Val 
        115                 120                 125             

Ser Asn Ser Val Gly Ser Val Leu Ser Ala Leu Ile Ser Thr Val Leu 
    130                 135                 140                 

Ile Leu Ile Met Thr Pro Val Phe Leu Val Tyr Phe Leu Leu Asp Gly 
145                 150                 155                 160 

His Lys Phe Leu Pro Met Leu Glu Arg Thr Ile Leu Lys Arg Asp Arg 
                165                 170                 175     

Leu His Ile Ala Gly Leu Leu Lys Asn Leu Asn Ala Thr Ile Ala Arg 
            180                 185                 190         

Tyr Ile Ser Gly Val Ser Ile Asp Ala Ile Ile Ile Gly Cys Leu Ala 
        195                 200                 205             

Tyr Ile Gly Tyr Ser Ile Ile Gly Leu Lys Tyr Ala Leu Val Phe Ala 
    210                 215                 220                 

Ile Phe Ser Gly Val Ala Asn Leu Ile Pro Tyr Val Gly Pro Ser Ile 
225                 230                 235                 240 

Gly Leu Ile Pro Met Ile Ile Ala Asn Ile Phe Thr Asp Pro His Arg 
                245                 250                 255     

Leu Leu Ile Ala Val Ile Tyr Met Leu Val Val Gln Gln Val Asp Gly 
            260                 265                 270         

Asn Ile Leu Tyr Pro Arg Ile Val Gly Ser Val Met Lys Val His Pro 
        275                 280                 285             

Ile Thr Ile Leu Val Leu Leu Leu Leu Ser Ser Asn Ile Tyr Gly Val 
    290                 295                 300                 

Val Gly Met Ile Val Ala Val Pro Thr Tyr Ser Ile Leu Lys Glu Ile 
305                 310                 315                 320 

Ser Lys Phe Leu Ser His Leu Tyr Glu Asn His Lys Ile Met Lys Glu 
                325                 330                 335     

Arg Glu Arg Glu Leu Ala Lys 
            340             

<210>   1687
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1687
gtgactccct ttttagcaaa agaatgcaaa ggaataccaa agataaaaat aaaaaacgtt   60
gatttaacaa cgttttacca aggaatgcaa aagaatgcaa aggaa                   105

<210>   1688
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1688
Met Thr Pro Phe Leu Ala Lys Glu Cys Lys Gly Ile Pro Lys Ile Lys 
1               5                   10                  15      

Ile Lys Asn Val Asp Leu Thr Thr Phe Tyr Gln Gly Met Gln Lys Asn 
            20                  25                  30          

Ala Lys Glu 
        35  

<210>   1689
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1689
gtgttaaaaa cagaacgtaa acaactaatt ttagaggagt taaatcaaca tcatgtagtt   60
tctctagaaa aattagttag tttgctagaa acgtcagaat caacggttcg aagagacttg   120
gatgagttgg aagcggaaaa caagcttcgt cgtgtgcatg gtggagcaga actcccctac   180
tccttacagg aagaagaaac cattcaagaa aaatctgtca aaaaccttca agaaaagaaa   240
ttgctggctc agaaagcagc ctctctcatt aaagaaaaag atgtcatctt tatcgatgct   300
ggaacaacaa ctgctttttt gattcatgaa ttggtcaata agaatgttac agttgtgacc   360
aactccattc accatgccgc tcagttggtt gaaaagcaga ttccaactgt catggttgga   420
ggaaacgtca agacggcgac agatgctagt atcgggggcg ttgctcttaa ccagattaac   480
caattgcact ttgaccgtgc ctttatcgga ataaatggtg ttgacgatgg ctattatacg   540
actcctgata tggaggaggg agctgtgaaa agagctattt tggagaatgc caagcagacc   600
tacgtcttgg tggattcgtc aaaaattgga caaacttgct ttgccaaggt agccccactc   660
aaacgcgcta tcgttatcac tagtcaaggg catgagctct tgcaggttat taaggagaaa   720
acggaggtaa tagaagta                                                 738

<210>   1690
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lactose phosphotransferase system repressor (lacR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902822 (e-133)

<400>   1690
Met Leu Lys Thr Glu Arg Lys Gln Leu Ile Leu Glu Glu Leu Asn Gln 
1               5                   10                  15      

His His Val Val Ser Leu Glu Lys Leu Val Ser Leu Leu Glu Thr Ser 
            20                  25                  30          

Glu Ser Thr Val Arg Arg Asp Leu Asp Glu Leu Glu Ala Glu Asn Lys 
        35                  40                  45              

Leu Arg Arg Val His Gly Gly Ala Glu Leu Pro Tyr Ser Leu Gln Glu 
    50                  55                  60                  

Glu Glu Thr Ile Gln Glu Lys Ser Val Lys Asn Leu Gln Glu Lys Lys 
65                  70                  75                  80  

Leu Leu Ala Gln Lys Ala Ala Ser Leu Ile Lys Glu Lys Asp Val Ile 
                85                  90                  95      

Phe Ile Asp Ala Gly Thr Thr Thr Ala Phe Leu Ile His Glu Leu Val 
            100                 105                 110         

Asn Lys Asn Val Thr Val Val Thr Asn Ser Ile His His Ala Ala Gln 
        115                 120                 125             

Leu Val Glu Lys Gln Ile Pro Thr Val Met Val Gly Gly Asn Val Lys 
    130                 135                 140                 

Thr Ala Thr Asp Ala Ser Ile Gly Gly Val Ala Leu Asn Gln Ile Asn 
145                 150                 155                 160 

Gln Leu His Phe Asp Arg Ala Phe Ile Gly Ile Asn Gly Val Asp Asp 
                165                 170                 175     

Gly Tyr Tyr Thr Thr Pro Asp Met Glu Glu Gly Ala Val Lys Arg Ala 
            180                 185                 190         

Ile Leu Glu Asn Ala Lys Gln Thr Tyr Val Leu Val Asp Ser Ser Lys 
        195                 200                 205             

Ile Gly Gln Thr Cys Phe Ala Lys Val Ala Pro Leu Lys Arg Ala Ile 
    210                 215                 220                 

Val Ile Thr Ser Gln Gly His Glu Leu Leu Gln Val Ile Lys Glu Lys 
225                 230                 235                 240 

Thr Glu Val Ile Glu Val 
                245     

<210>   1691
<211>   909
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1691
atgatttata cagtcacact caatccatcc attgactata tcgttcgttt ggaccaagtc   60
aaagttggta gtgtcaatcg tatggacagt gatgataagt ttgctggtgg gaaaggaatc   120
aatgtcagcc gtgtcttgaa acgtttgaat ataccaaata cagcgacggg atttatcggt   180
ggctttactg gtaaatttat cacagatact ttagcagagg aagaaatcga gacacgtttt   240
gtccaggtgg cagaagatac tcgtatcaat gttaaaatca aagcagacca agaaacagaa   300
atcaacggaa cgggtccaac tgttgaatcg gttcagctag aagaattgaa agctatttta   360
tctagtctga cagcagaaga tacagttgtc tttgcaggtt caagtgctaa aaatctaggc   420
aatgttatct ataaggattt gatttccttg acgcgccaga ctggtgcgca agtggtctgt   480
gactttgaag gacagacctt aattgatagt ttggactacc agcctcttct tgtaaaacca   540
aacaatcatg aacttggagc gatttttggg gttaaactcg aaagtttaga tgaaattgag   600
aaatacgctc gtgagttact ggctaagggt gctcaaaatg ttattatctc tatggctggt   660
gatggtgccc ttcttgtcac atctgaggga gcttacttcg ctaaaccaat caaaggaaca   720
gtcaaaaatt cagttggagc tggtgattct atggttgctg gattcacagg tgaatttgtc   780
aaatcaaaag acgtagtaga agccttcaaa tggggagtgg cttgcggaac ggcaactacc   840
ttctcagatg acttggcaac ggcggaattt attaaagaaa catatggaaa agttgaggta   900
gaaaaacga                                                           909

<210>   1692
<211>   303
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   1-phosphofructokinase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902823 (e-168)

<400>   1692
Met Ile Tyr Thr Val Thr Leu Asn Pro Ser Ile Asp Tyr Ile Val Arg 
1               5                   10                  15      

Leu Asp Gln Val Lys Val Gly Ser Val Asn Arg Met Asp Ser Asp Asp 
            20                  25                  30          

Lys Phe Ala Gly Gly Lys Gly Ile Asn Val Ser Arg Val Leu Lys Arg 
        35                  40                  45              

Leu Asn Ile Pro Asn Thr Ala Thr Gly Phe Ile Gly Gly Phe Thr Gly 
    50                  55                  60                  

Lys Phe Ile Thr Asp Thr Leu Ala Glu Glu Glu Ile Glu Thr Arg Phe 
65                  70                  75                  80  

Val Gln Val Ala Glu Asp Thr Arg Ile Asn Val Lys Ile Lys Ala Asp 
                85                  90                  95      

Gln Glu Thr Glu Ile Asn Gly Thr Gly Pro Thr Val Glu Ser Val Gln 
            100                 105                 110         

Leu Glu Glu Leu Lys Ala Ile Leu Ser Ser Leu Thr Ala Glu Asp Thr 
        115                 120                 125             

Val Val Phe Ala Gly Ser Ser Ala Lys Asn Leu Gly Asn Val Ile Tyr 
    130                 135                 140                 

Lys Asp Leu Ile Ser Leu Thr Arg Gln Thr Gly Ala Gln Val Val Cys 
145                 150                 155                 160 

Asp Phe Glu Gly Gln Thr Leu Ile Asp Ser Leu Asp Tyr Gln Pro Leu 
                165                 170                 175     

Leu Val Lys Pro Asn Asn His Glu Leu Gly Ala Ile Phe Gly Val Lys 
            180                 185                 190         

Leu Glu Ser Leu Asp Glu Ile Glu Lys Tyr Ala Arg Glu Leu Leu Ala 
        195                 200                 205             

Lys Gly Ala Gln Asn Val Ile Ile Ser Met Ala Gly Asp Gly Ala Leu 
    210                 215                 220                 

Leu Val Thr Ser Glu Gly Ala Tyr Phe Ala Lys Pro Ile Lys Gly Thr 
225                 230                 235                 240 

Val Lys Asn Ser Val Gly Ala Gly Asp Ser Met Val Ala Gly Phe Thr 
                245                 250                 255     

Gly Glu Phe Val Lys Ser Lys Asp Val Val Glu Ala Phe Lys Trp Gly 
            260                 265                 270         

Val Ala Cys Gly Thr Ala Thr Thr Phe Ser Asp Asp Leu Ala Thr Ala 
        275                 280                 285             

Glu Phe Ile Lys Glu Thr Tyr Gly Lys Val Glu Val Glu Lys Arg 
    290                 295                 300             

<210>   1693
<211>   1950
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1693
atgaaaattc aagacctatt gagaaaagat gtcatgttgc tagatttgca ggcaactgaa   60
aaaacagctg tcatcgacga gatgattaaa aatttgacag accacggtta tgtaacagat   120
tttgaaacat ttaaagaagg aattttggcg cgtgaagctt tgacttctac tggtttgggt   180
gatggaatcg caatgcctca cagcaaaaac gctgctgtca aagaagcgac agttctattt   240
gctaagtcaa ataagggtgt tgactacgag agcttggatg gacaagcaac tgacctcttc   300
ttcatgattg cagctccaga aggtgccaat gatactcact tggcagcctt ggcagaattg   360
tctcaatact tgatgaaaga cggttttgca gacaaacttc gtcaagcaac atctgcagac   420
caagttatcg aactttttga ccaagcttca gaaaaaactg aggaacttgt tcaagcacct   480
gctaatgact ctggtgactt tatcgtagct gttacagctt gtacaacagg tattgcccac   540
acttacatgg cccaagaagc ccttcaaaaa gtagctgctg aaatgggggt tggtatcaag   600
gtcgaaacca acggtgctag cggtgttgga aatcaactaa ctgcagaaga tatccgtaag   660
gctaaagcta ttatcattgc agcagacaag gccgttgaaa tggatcgatt tgatggaaaa   720
ccattgatca atcgtccagt tgctgacggt atccgtaaga cagaagagct aattaacttg   780
gctctttcag gagatactga agtctaccgt gccgctaatg gtgccaaagc tgcaacagcc   840
tctaacgaaa aacaaagcct tggtggtgcc ttgtacaaac acttgatgag tggtgtatct   900
caaatgttac cattcgttat cggtggtggt atcatgattg cccttgcctt cttgattgac   960
ggtgctttgg gtgttccaaa tgaaaacctt ggcaatcttg gttcttacca tgagttagct   1020
tctatgttca tgaaaattgg tggagctgcc tttggtttga tgcttccagt ctttgcgggt   1080
tatgttgcct actctattgc tgaaaaaccg ggtttggtag caggtttcgt ggctggtgct   1140
attgccaaag aaggttttgc ctttggtaaa attccttatg ccgcaggtgg tgaagcaact   1200
tcaactcttg caggtgtctc atctggtttc ctaggtgccc ttgttggtgg atttatcgca   1260
ggtgccttgg ttcttgccat caagaaatac gttaaagttc ctcgttcact cgaaggtgct   1320
aaatcaatcc ttctattgcc acttcttgga acaatcttga caggatttgt tatgctagct   1380
gtgaatatcc caatggctgc aatcaacact gctatgaatg acttcctagg cggtcttgga   1440
ggaggttcag ctgtccttct tggtatcgtc cttggtggaa tgatggctgt tgacatgggt   1500
ggaccagtta ataaagcagc ttatgtcttt ggtacaggta cgcttgcagc aactgtttct   1560
tcaggtggtt ctgtagccat ggcagcagtt atggctggag gaatggtgcc accacttgca   1620
atctttgtcg caactcttct tttcaaagat aaatttacta aggaagaacg taactctggt   1680
ttgacaaaca tcatcatggg cttgtcattt atcactgagg gagcgattcc atttggtgcc   1740
gctgacccag ctcgtgcgat tccaagcttc atccttggtt cagcagtagc aggtggactc   1800
gttggtctta ctggtatcaa actcatggcg ccacacggag gaatcttcgt tatcgccctt   1860
acttcaaatg ctctccttta cctcgtttct gtcttggtag gagcaatcgt aagtggtgtg   1920
gtttatggtt acctacgcaa accacaagca                                    1950

<210>   1694
<211>   650
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, fructose specific IIABC components
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902824 (0.E+01)

<400>   1694
Met Lys Ile Gln Asp Leu Leu Arg Lys Asp Val Met Leu Leu Asp Leu 
1               5                   10                  15      

Gln Ala Thr Glu Lys Thr Ala Val Ile Asp Glu Met Ile Lys Asn Leu 
            20                  25                  30          

Thr Asp His Gly Tyr Val Thr Asp Phe Glu Thr Phe Lys Glu Gly Ile 
        35                  40                  45              

Leu Ala Arg Glu Ala Leu Thr Ser Thr Gly Leu Gly Asp Gly Ile Ala 
    50                  55                  60                  

Met Pro His Ser Lys Asn Ala Ala Val Lys Glu Ala Thr Val Leu Phe 
65                  70                  75                  80  

Ala Lys Ser Asn Lys Gly Val Asp Tyr Glu Ser Leu Asp Gly Gln Ala 
                85                  90                  95      

Thr Asp Leu Phe Phe Met Ile Ala Ala Pro Glu Gly Ala Asn Asp Thr 
            100                 105                 110         

His Leu Ala Ala Leu Ala Glu Leu Ser Gln Tyr Leu Met Lys Asp Gly 
        115                 120                 125             

Phe Ala Asp Lys Leu Arg Gln Ala Thr Ser Ala Asp Gln Val Ile Glu 
    130                 135                 140                 

Leu Phe Asp Gln Ala Ser Glu Lys Thr Glu Glu Leu Val Gln Ala Pro 
145                 150                 155                 160 

Ala Asn Asp Ser Gly Asp Phe Ile Val Ala Val Thr Ala Cys Thr Thr 
                165                 170                 175     

Gly Ile Ala His Thr Tyr Met Ala Gln Glu Ala Leu Gln Lys Val Ala 
            180                 185                 190         

Ala Glu Met Gly Val Gly Ile Lys Val Glu Thr Asn Gly Ala Ser Gly 
        195                 200                 205             

Val Gly Asn Gln Leu Thr Ala Glu Asp Ile Arg Lys Ala Lys Ala Ile 
    210                 215                 220                 

Ile Ile Ala Ala Asp Lys Ala Val Glu Met Asp Arg Phe Asp Gly Lys 
225                 230                 235                 240 

Pro Leu Ile Asn Arg Pro Val Ala Asp Gly Ile Arg Lys Thr Glu Glu 
                245                 250                 255     

Leu Ile Asn Leu Ala Leu Ser Gly Asp Thr Glu Val Tyr Arg Ala Ala 
            260                 265                 270         

Asn Gly Ala Lys Ala Ala Thr Ala Ser Asn Glu Lys Gln Ser Leu Gly 
        275                 280                 285             

Gly Ala Leu Tyr Lys His Leu Met Ser Gly Val Ser Gln Met Leu Pro 
    290                 295                 300                 

Phe Val Ile Gly Gly Gly Ile Met Ile Ala Leu Ala Phe Leu Ile Asp 
305                 310                 315                 320 

Gly Ala Leu Gly Val Pro Asn Glu Asn Leu Gly Asn Leu Gly Ser Tyr 
                325                 330                 335     

His Glu Leu Ala Ser Met Phe Met Lys Ile Gly Gly Ala Ala Phe Gly 
            340                 345                 350         

Leu Met Leu Pro Val Phe Ala Gly Tyr Val Ala Tyr Ser Ile Ala Glu 
        355                 360                 365             

Lys Pro Gly Leu Val Ala Gly Phe Val Ala Gly Ala Ile Ala Lys Glu 
    370                 375                 380                 

Gly Phe Ala Phe Gly Lys Ile Pro Tyr Ala Ala Gly Gly Glu Ala Thr 
385                 390                 395                 400 

Ser Thr Leu Ala Gly Val Ser Ser Gly Phe Leu Gly Ala Leu Val Gly 
                405                 410                 415     

Gly Phe Ile Ala Gly Ala Leu Val Leu Ala Ile Lys Lys Tyr Val Lys 
            420                 425                 430         

Val Pro Arg Ser Leu Glu Gly Ala Lys Ser Ile Leu Leu Leu Pro Leu 
        435                 440                 445             

Leu Gly Thr Ile Leu Thr Gly Phe Val Met Leu Ala Val Asn Ile Pro 
    450                 455                 460                 

Met Ala Ala Ile Asn Thr Ala Met Asn Asp Phe Leu Gly Gly Leu Gly 
465                 470                 475                 480 

Gly Gly Ser Ala Val Leu Leu Gly Ile Val Leu Gly Gly Met Met Ala 
                485                 490                 495     

Val Asp Met Gly Gly Pro Val Asn Lys Ala Ala Tyr Val Phe Gly Thr 
            500                 505                 510         

Gly Thr Leu Ala Ala Thr Val Ser Ser Gly Gly Ser Val Ala Met Ala 
        515                 520                 525             

Ala Val Met Ala Gly Gly Met Val Pro Pro Leu Ala Ile Phe Val Ala 
    530                 535                 540                 

Thr Leu Leu Phe Lys Asp Lys Phe Thr Lys Glu Glu Arg Asn Ser Gly 
545                 550                 555                 560 

Leu Thr Asn Ile Ile Met Gly Leu Ser Phe Ile Thr Glu Gly Ala Ile 
                565                 570                 575     

Pro Phe Gly Ala Ala Asp Pro Ala Arg Ala Ile Pro Ser Phe Ile Leu 
            580                 585                 590         

Gly Ser Ala Val Ala Gly Gly Leu Val Gly Leu Thr Gly Ile Lys Leu 
        595                 600                 605             

Met Ala Pro His Gly Gly Ile Phe Val Ile Ala Leu Thr Ser Asn Ala 
    610                 615                 620                 

Leu Leu Tyr Leu Val Ser Val Leu Val Gly Ala Ile Val Ser Gly Val 
625                 630                 635                 640 

Val Tyr Gly Tyr Leu Arg Lys Pro Gln Ala 
                645                 650 

<210>   1695
<211>   156
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1695
atgaaaagat tggaccgttt ggtgcagtct ttttctcttc ccgaaatgcc tgtgaaatat   60
ggtataatag aagaatggca aacaagaata caagtacaac aagacggaga ccgtctaaag   120
cagaactgga aagaaaagaa gcgattcaac gaatgt                             156

<210>   1696
<211>   52
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1696
Met Lys Arg Leu Asp Arg Leu Val Gln Ser Phe Ser Leu Pro Glu Met 
1               5                   10                  15      

Pro Val Lys Tyr Gly Ile Ile Glu Glu Trp Gln Thr Arg Ile Gln Val 
            20                  25                  30          

Gln Gln Asp Gly Asp Arg Leu Lys Gln Asn Trp Lys Glu Lys Lys Arg 
        35                  40                  45              

Phe Asn Glu Cys 
    50          

<210>   1697
<211>   2223
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1697
atgttgattt cgttaggaat tgcgatttta ttgattttcg cagccttcaa attaggggct   60
gcaggtataa ccctttataa tttaattcgc ttgctagtgg gtagcctagc ttatctggcg   120
atattcggcc tattaatcta tctcttcttt ttcaagtgga tacgaaaaca ggaaggactc   180
ttatctggct ttttcaccat atttgctggc ttactcttga tttttgaggc ctacttggtt   240
tggaaatatg gtttggacaa gtccgttcta aaagggacca tggctcaggt tgtgacagat   300
ctgactggtt ttcgaacgac tagctttgct ggagggggct tgatcggggt cgctctttat   360
attccaacag cctttctctt ttcaaatatc ggaacttact ttattggttc tatcttgatt   420
ttagtgggtt ctctcctagt cagcccttgg tctgtttacg atattgctga atttttcagt   480
agaggctttg ccaaatggtg ggaagggcac gagcgtcgaa aagaggaacg ctttgtcaaa   540
caagaagaaa aagctcgcca aaaggctgag aaagaggcta gattagaaca agaagagact   600
gaaaaagcct tactcgattt gcctcctgtt gatatggaaa cgggtgaaat tctgacagag   660
gaagctgttc aaaatcttcc acctattcca gaagaaaagt gggtggaacc agaaatcatc   720
ctgcctcaag ctgaacttaa attccctgaa caggaagatg actcagatga cgaagatgtt   780
caggtcgatt tttcagccaa agaagccctt gaatacaaac ttccaagctt acaactcttt   840
gcaccagata aaccaaaaga tcagtctaaa gagaagaaaa ttgtcagaga aaatatcaaa   900
atcttagaag caacctttgc tagctttggt attaaggtaa cagttgaacg ggccgaaatt   960
gggccatcag tgaccaagta tgaagtcaag ccggctgttg gtgtaagggt caaccgcatt   1020
tccaatctat cagatgacct cgctctagcc ttggctgcca aagatgtccg gattgaagca   1080
ccaatccctg ggaaatccct aatcggaatt gaagtgccca actccgatat tgccactgta   1140
tctttccgag aactatggga acaatcgcaa acgaaagcag aaaatttctt ggaaattcct   1200
ttagggaagg ctgttaatgg aaccgcaaga gcttttgacc tttctaaaat gccccacttg   1260
ctagttgcag gttcaacggg ttcagggaag tcagtagcag ttaacggcat tattgctagc   1320
attctcatga aggcgagacc agatcaagtt aaatttatga tggtcgatcc caagatggtt   1380
gagttatctg tttacaatga tattccccac ctcttgattc cagtcgtgac caatccacgc   1440
aaagccagca aggctctgca aaaggttgtg gatgaaatgg aaaaccgtta tgaactcttt   1500
gccaaggtgg gagttcggaa tattgcaggt tttaatgcca aggtagaaga gttcaattcc   1560
cagtctgagt acaagcaaat tccgctacca ttcattgtcg tgattgtgga tgagttggct   1620
gacctcatga tggtggccag caaggaagtg gaagatgcta tcatccgtct tgggcagaag   1680
gcgcgtgctg caggtatcca catgattctt gcaactcagc gtccatctgt tgatgtcatc   1740
tctggtttga ttaaggccaa tgttccatct cgtgtagcat ttgcggtttc atcaggaaca   1800
gactcccgta cgattttgga tgaaaatgga gcagaaaaac ttcttggtcg aggagacatg   1860
ctctttaaac cgattgatga aaatcatcca gttcgtctcc aaggctcctt tatctcggat   1920
gacgatgttg agcgcattgt gaacttcatc aagactcagg cagatgcaga ctacgatgag   1980
agttttgatc caggtgaggt ttctgaaaat gaaggagaat tttcggatgg agatgctggt   2040
ggtgatccgc tttttgaaga agctaagtct ttggttatcg aaacacagaa agccagtgcg   2100
tctatgattc agcgtcgttt atcagttgga tttaaccgtg cgacccgtct catggaagaa   2160
ctggagatag caggtgtcat cggtccagct gaaggtacca aacctcgaaa agtgttacaa   2220
caa                                                                 2223

<210>   1698
<211>   741
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   stage III sporulation protein E (spoE)
<223>   Cellular location: membrane
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15902825 (0.E+01)

<400>   1698
Met Leu Ile Ser Leu Gly Ile Ala Ile Leu Leu Ile Phe Ala Ala Phe 
1               5                   10                  15      

Lys Leu Gly Ala Ala Gly Ile Thr Leu Tyr Asn Leu Ile Arg Leu Leu 
            20                  25                  30          

Val Gly Ser Leu Ala Tyr Leu Ala Ile Phe Gly Leu Leu Ile Tyr Leu 
        35                  40                  45              

Phe Phe Phe Lys Trp Ile Arg Lys Gln Glu Gly Leu Leu Ser Gly Phe 
    50                  55                  60                  

Phe Thr Ile Phe Ala Gly Leu Leu Leu Ile Phe Glu Ala Tyr Leu Val 
65                  70                  75                  80  

Trp Lys Tyr Gly Leu Asp Lys Ser Val Leu Lys Gly Thr Met Ala Gln 
                85                  90                  95      

Val Val Thr Asp Leu Thr Gly Phe Arg Thr Thr Ser Phe Ala Gly Gly 
            100                 105                 110         

Gly Leu Ile Gly Val Ala Leu Tyr Ile Pro Thr Ala Phe Leu Phe Ser 
        115                 120                 125             

Asn Ile Gly Thr Tyr Phe Ile Gly Ser Ile Leu Ile Leu Val Gly Ser 
    130                 135                 140                 

Leu Leu Val Ser Pro Trp Ser Val Tyr Asp Ile Ala Glu Phe Phe Ser 
145                 150                 155                 160 

Arg Gly Phe Ala Lys Trp Trp Glu Gly His Glu Arg Arg Lys Glu Glu 
                165                 170                 175     

Arg Phe Val Lys Gln Glu Glu Lys Ala Arg Gln Lys Ala Glu Lys Glu 
            180                 185                 190         

Ala Arg Leu Glu Gln Glu Glu Thr Glu Lys Ala Leu Leu Asp Leu Pro 
        195                 200                 205             

Pro Val Asp Met Glu Thr Gly Glu Ile Leu Thr Glu Glu Ala Val Gln 
    210                 215                 220                 

Asn Leu Pro Pro Ile Pro Glu Glu Lys Trp Val Glu Pro Glu Ile Ile 
225                 230                 235                 240 

Leu Pro Gln Ala Glu Leu Lys Phe Pro Glu Gln Glu Asp Asp Ser Asp 
                245                 250                 255     

Asp Glu Asp Val Gln Val Asp Phe Ser Ala Lys Glu Ala Leu Glu Tyr 
            260                 265                 270         

Lys Leu Pro Ser Leu Gln Leu Phe Ala Pro Asp Lys Pro Lys Asp Gln 
        275                 280                 285             

Ser Lys Glu Lys Lys Ile Val Arg Glu Asn Ile Lys Ile Leu Glu Ala 
    290                 295                 300                 

Thr Phe Ala Ser Phe Gly Ile Lys Val Thr Val Glu Arg Ala Glu Ile 
305                 310                 315                 320 

Gly Pro Ser Val Thr Lys Tyr Glu Val Lys Pro Ala Val Gly Val Arg 
                325                 330                 335     

Val Asn Arg Ile Ser Asn Leu Ser Asp Asp Leu Ala Leu Ala Leu Ala 
            340                 345                 350         

Ala Lys Asp Val Arg Ile Glu Ala Pro Ile Pro Gly Lys Ser Leu Ile 
        355                 360                 365             

Gly Ile Glu Val Pro Asn Ser Asp Ile Ala Thr Val Ser Phe Arg Glu 
    370                 375                 380                 

Leu Trp Glu Gln Ser Gln Thr Lys Ala Glu Asn Phe Leu Glu Ile Pro 
385                 390                 395                 400 

Leu Gly Lys Ala Val Asn Gly Thr Ala Arg Ala Phe Asp Leu Ser Lys 
                405                 410                 415     

Met Pro His Leu Leu Val Ala Gly Ser Thr Gly Ser Gly Lys Ser Val 
            420                 425                 430         

Ala Val Asn Gly Ile Ile Ala Ser Ile Leu Met Lys Ala Arg Pro Asp 
        435                 440                 445             

Gln Val Lys Phe Met Met Val Asp Pro Lys Met Val Glu Leu Ser Val 
    450                 455                 460                 

Tyr Asn Asp Ile Pro His Leu Leu Ile Pro Val Val Thr Asn Pro Arg 
465                 470                 475                 480 

Lys Ala Ser Lys Ala Leu Gln Lys Val Val Asp Glu Met Glu Asn Arg 
                485                 490                 495     

Tyr Glu Leu Phe Ala Lys Val Gly Val Arg Asn Ile Ala Gly Phe Asn 
            500                 505                 510         

Ala Lys Val Glu Glu Phe Asn Ser Gln Ser Glu Tyr Lys Gln Ile Pro 
        515                 520                 525             

Leu Pro Phe Ile Val Val Ile Val Asp Glu Leu Ala Asp Leu Met Met 
    530                 535                 540                 

Val Ala Ser Lys Glu Val Glu Asp Ala Ile Ile Arg Leu Gly Gln Lys 
545                 550                 555                 560 

Ala Arg Ala Ala Gly Ile His Met Ile Leu Ala Thr Gln Arg Pro Ser 
                565                 570                 575     

Val Asp Val Ile Ser Gly Leu Ile Lys Ala Asn Val Pro Ser Arg Val 
            580                 585                 590         

Ala Phe Ala Val Ser Ser Gly Thr Asp Ser Arg Thr Ile Leu Asp Glu 
        595                 600                 605             

Asn Gly Ala Glu Lys Leu Leu Gly Arg Gly Asp Met Leu Phe Lys Pro 
    610                 615                 620                 

Ile Asp Glu Asn His Pro Val Arg Leu Gln Gly Ser Phe Ile Ser Asp 
625                 630                 635                 640 

Asp Asp Val Glu Arg Ile Val Asn Phe Ile Lys Thr Gln Ala Asp Ala 
                645                 650                 655     

Asp Tyr Asp Glu Ser Phe Asp Pro Gly Glu Val Ser Glu Asn Glu Gly 
            660                 665                 670         

Glu Phe Ser Asp Gly Asp Ala Gly Gly Asp Pro Leu Phe Glu Glu Ala 
        675                 680                 685             

Lys Ser Leu Val Ile Glu Thr Gln Lys Ala Ser Ala Ser Met Ile Gln 
    690                 695                 700                 

Arg Arg Leu Ser Val Gly Phe Asn Arg Ala Thr Arg Leu Met Glu Glu 
705                 710                 715                 720 

Leu Glu Ile Ala Gly Val Ile Gly Pro Ala Glu Gly Thr Lys Pro Arg 
                725                 730                 735     

Lys Val Leu Gln Gln 
            740     

<210>   1699
<211>   531
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1699
ttgtatcatg aaacggagct tgcgacaaga aagggaaatt tctctttttt taagattttt   60
ttaaagaaac agagtataat aaatcataat caaaggagag aatgtatgtc taactatcgt   120
agaacttcaa aaccaaaaac agaacacatc aaaaaaggct ttacagtctt tcaaaaaacc   180
gttgctacaa tcgctagtat ccttggcttg attaccgcaa gtatcacgat tatgaacgcc   240
ttggataata acaaaaatat taaaaaagaa cctacgacaa gccagacgac aaccattgtc   300
aaagaaatcc aaaaggaatc ccctaaggaa aacaccagtc caactaaaga gactaacact   360
agtcaagaaa aaacacagca agaggaaaca ccaaaatcta gcgtcaagga agagaaaaaa   420
gaagatcaga aaacagcaac tcaggactct tctactcctg cttcaagtaa acctgctact   480
gaaaacgaaa aacagtccaa tgcgccaact tcagaaaata aaagcaatca a            531

<210>   1700
<211>   177
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902826 (4.E-98)

<400>   1700
Met Tyr His Glu Thr Glu Leu Ala Thr Arg Lys Gly Asn Phe Ser Phe 
1               5                   10                  15      

Phe Lys Ile Phe Leu Lys Lys Gln Ser Ile Ile Asn His Asn Gln Arg 
            20                  25                  30          

Arg Glu Cys Met Ser Asn Tyr Arg Arg Thr Ser Lys Pro Lys Thr Glu 
        35                  40                  45              

His Ile Lys Lys Gly Phe Thr Val Phe Gln Lys Thr Val Ala Thr Ile 
    50                  55                  60                  

Ala Ser Ile Leu Gly Leu Ile Thr Ala Ser Ile Thr Ile Met Asn Ala 
65                  70                  75                  80  

Leu Asp Asn Asn Lys Asn Ile Lys Lys Glu Pro Thr Thr Ser Gln Thr 
                85                  90                  95      

Thr Thr Ile Val Lys Glu Ile Gln Lys Glu Ser Pro Lys Glu Asn Thr 
            100                 105                 110         

Ser Pro Thr Lys Glu Thr Asn Thr Ser Gln Glu Lys Thr Gln Gln Glu 
        115                 120                 125             

Glu Thr Pro Lys Ser Ser Val Lys Glu Glu Lys Lys Glu Asp Gln Lys 
    130                 135                 140                 

Thr Ala Thr Gln Asp Ser Ser Thr Pro Ala Ser Ser Lys Pro Ala Thr 
145                 150                 155                 160 

Glu Asn Glu Lys Gln Ser Asn Ala Pro Thr Ser Glu Asn Lys Ser Asn 
                165                 170                 175     

Gln 
    

<210>   1701
<211>   1200
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1701
ttgtcgcaag ctccgtttca tgatacaata gaggaagtga ttttagaaag cgtgagaaac   60
atgatttact ttgataattc agcgacgacc aagccttatc ctgaagccct tgaaacctat   120
atgcaggtcg cttcaaaaat tttaggaaac ccatctagtc tccatcgttt gggagaccaa   180
gcaacacgaa tcttagatgc ttctcgccaa cagattgcag atttaatcgg taagaaaagc   240
gatgaaatct tctttacctc gggtggaaca gaaggggata actggcttat caagggtgtg   300
gcctttgaaa aagctcagtt tggcaagcac atcattgttt cagccattga acatccagca   360
gtcaaagagt cagccctctg gttgaaaagt caaggatttg aagtggattt tgctccagtt   420
gataagaaag gcttggtcga tgttgaggcg ttagcaggtt tgatacggca tgatacaatc   480
ctcgtttcca tcatggctgt gaacaatgaa atcggctcta tccaacctat tgaggctatt   540
tcagaattct tggcagacaa gccgactatt tccttccacg ttgatgcggt tcaggcgctt   600
gccaaaattc cgactgaaaa gtatctgaca gaacgggtgg attgcgcgac tttctctagt   660
cacaagttcc acggggttcg aggtgttggc tttgtctata tcaaatctgg caagaagatt   720
acacctcttc ttacaggtgg tggccaggag cgagattatc gttcgacaac tgaaaatgtg   780
gcagggattg cagcgacagc caaggccctc cgtttgtcta tggaaaagct agatatcttt   840
aggagcaaga ctgggcagat gaaggcagtg attcgccaag ctcttctgaa ctatccggat   900
atttttgtct tttcagatga ggaaaacttt gcacctcata ttctgacttt tggaatcaaa   960
ggtgttcgag gtgaagtcat cgttcacgcc tttgaagact atgatatttt catctcaaca   1020
acctcagctt gttcatctaa ggcaggaaaa ccagccggta ccttgattgc catgggagtg   1080
gacaaagata aggccaagtc agctgtgcgt cttagcctag acttggaaaa tgatatgagt   1140
caggtcgagc agtttttgac caagttaaaa ttgatttaca atcaaactag aaaagtaaga   1200

<210>   1702
<211>   400
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aminotransferase, class-V
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902827 (0.E+01)

<400>   1702
Met Ser Gln Ala Pro Phe His Asp Thr Ile Glu Glu Val Ile Leu Glu 
1               5                   10                  15      

Ser Val Arg Asn Met Ile Tyr Phe Asp Asn Ser Ala Thr Thr Lys Pro 
            20                  25                  30          

Tyr Pro Glu Ala Leu Glu Thr Tyr Met Gln Val Ala Ser Lys Ile Leu 
        35                  40                  45              

Gly Asn Pro Ser Ser Leu His Arg Leu Gly Asp Gln Ala Thr Arg Ile 
    50                  55                  60                  

Leu Asp Ala Ser Arg Gln Gln Ile Ala Asp Leu Ile Gly Lys Lys Ser 
65                  70                  75                  80  

Asp Glu Ile Phe Phe Thr Ser Gly Gly Thr Glu Gly Asp Asn Trp Leu 
                85                  90                  95      

Ile Lys Gly Val Ala Phe Glu Lys Ala Gln Phe Gly Lys His Ile Ile 
            100                 105                 110         

Val Ser Ala Ile Glu His Pro Ala Val Lys Glu Ser Ala Leu Trp Leu 
        115                 120                 125             

Lys Ser Gln Gly Phe Glu Val Asp Phe Ala Pro Val Asp Lys Lys Gly 
    130                 135                 140                 

Leu Val Asp Val Glu Ala Leu Ala Gly Leu Ile Arg His Asp Thr Ile 
145                 150                 155                 160 

Leu Val Ser Ile Met Ala Val Asn Asn Glu Ile Gly Ser Ile Gln Pro 
                165                 170                 175     

Ile Glu Ala Ile Ser Glu Phe Leu Ala Asp Lys Pro Thr Ile Ser Phe 
            180                 185                 190         

His Val Asp Ala Val Gln Ala Leu Ala Lys Ile Pro Thr Glu Lys Tyr 
        195                 200                 205             

Leu Thr Glu Arg Val Asp Cys Ala Thr Phe Ser Ser His Lys Phe His 
    210                 215                 220                 

Gly Val Arg Gly Val Gly Phe Val Tyr Ile Lys Ser Gly Lys Lys Ile 
225                 230                 235                 240 

Thr Pro Leu Leu Thr Gly Gly Gly Gln Glu Arg Asp Tyr Arg Ser Thr 
                245                 250                 255     

Thr Glu Asn Val Ala Gly Ile Ala Ala Thr Ala Lys Ala Leu Arg Leu 
            260                 265                 270         

Ser Met Glu Lys Leu Asp Ile Phe Arg Ser Lys Thr Gly Gln Met Lys 
        275                 280                 285             

Ala Val Ile Arg Gln Ala Leu Leu Asn Tyr Pro Asp Ile Phe Val Phe 
    290                 295                 300                 

Ser Asp Glu Glu Asn Phe Ala Pro His Ile Leu Thr Phe Gly Ile Lys 
305                 310                 315                 320 

Gly Val Arg Gly Glu Val Ile Val His Ala Phe Glu Asp Tyr Asp Ile 
                325                 330                 335     

Phe Ile Ser Thr Thr Ser Ala Cys Ser Ser Lys Ala Gly Lys Pro Ala 
            340                 345                 350         

Gly Thr Leu Ile Ala Met Gly Val Asp Lys Asp Lys Ala Lys Ser Ala 
        355                 360                 365             

Val Arg Leu Ser Leu Asp Leu Glu Asn Asp Met Ser Gln Val Glu Gln 
    370                 375                 380                 

Phe Leu Thr Lys Leu Lys Leu Ile Tyr Asn Gln Thr Arg Lys Val Arg 
385                 390                 395                 400 


<210>   1703
<211>   1212
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1703
atgcagtatt cagaaattat gattcgctac ggagagttgt caaccaaggg taaaaaccgt   60
atgcgtttca tcaataaact tcgtaataat atttcggacg ttttgtctat ctatacccaa   120
gttaaggtaa cagcagatcg cgaccgtgcc cacgcttacc tcaatggagc tgattacaca   180
gcagttgcag aatctctcaa acaagttttt ggaattcaaa acttttctcc tgtttataag   240
gttgaaaaat ctgtagaagt tttgaagtct tctgtccaag agattatgcg ggacatctac   300
aaggaaggta tgacctttaa gatttctagc aagcgtagcg accacaactt tgaacttgat   360
agtcgtgaac tcaaccaaac acttggaggg gctgtattcg aagccattcc aaatgtgcaa   420
gttcaaatga aaagtcctga catcaatctt caggtggaga ttcgtgaaga agcagcctat   480
ctttcttatg aaaccattcg tggggctggt ggtttgccag ttggaacttc aggtaaaggg   540
atgctcatgt tgtcaggagg gattgactca cctgtagcag gttatcttgc tcttaagcgt   600
ggggtggata tcgaggcagt tcactttgct agtccaccat atactagtcc tggtgccctc   660
aagaaagcgc aggacttgac ccgtaaattg accaagtttg gcggaaatat ccagtttata   720
gaggtgcctt tcacagagat tcaagaggaa atcaaagcca aagcgccaga agcttatttg   780
atgactctaa ctcgtcgctt tatgatgcgg attactgacc gtattcgtga ggtacgaaat   840
ggtttggtta tcatcaatgg ggaaagtcta ggtcaagtag ccagccaaac ccttgaaagt   900
atgaaggcta tcaatgctgt taccaacact cccatcattc gtcctgtggt taccatggac   960
aagttggaaa tcattgacat cgcccaggaa atcgatacct ttgacatttc aatccaaccg   1020
tttgaagact gttgtaccat ttttgcacca gatcgtccaa aaacaaatcc taaaattaag   1080
aatgcggagc agtacgaagc gcgtatggat gttgaaggct tggttgagcg agcagtggct   1140
ggaatcatga ttactgaaat cacacctcaa gccgaaaaag atgaagttga tgacttgatt   1200
gacaatctgc tc                                                       1212

<210>   1704
<211>   404
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thiazole biosynthesis protein ThiI (thiI)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902828 (0.E+01)

<400>   1704
Met Gln Tyr Ser Glu Ile Met Ile Arg Tyr Gly Glu Leu Ser Thr Lys 
1               5                   10                  15      

Gly Lys Asn Arg Met Arg Phe Ile Asn Lys Leu Arg Asn Asn Ile Ser 
            20                  25                  30          

Asp Val Leu Ser Ile Tyr Thr Gln Val Lys Val Thr Ala Asp Arg Asp 
        35                  40                  45              

Arg Ala His Ala Tyr Leu Asn Gly Ala Asp Tyr Thr Ala Val Ala Glu 
    50                  55                  60                  

Ser Leu Lys Gln Val Phe Gly Ile Gln Asn Phe Ser Pro Val Tyr Lys 
65                  70                  75                  80  

Val Glu Lys Ser Val Glu Val Leu Lys Ser Ser Val Gln Glu Ile Met 
                85                  90                  95      

Arg Asp Ile Tyr Lys Glu Gly Met Thr Phe Lys Ile Ser Ser Lys Arg 
            100                 105                 110         

Ser Asp His Asn Phe Glu Leu Asp Ser Arg Glu Leu Asn Gln Thr Leu 
        115                 120                 125             

Gly Gly Ala Val Phe Glu Ala Ile Pro Asn Val Gln Val Gln Met Lys 
    130                 135                 140                 

Ser Pro Asp Ile Asn Leu Gln Val Glu Ile Arg Glu Glu Ala Ala Tyr 
145                 150                 155                 160 

Leu Ser Tyr Glu Thr Ile Arg Gly Ala Gly Gly Leu Pro Val Gly Thr 
                165                 170                 175     

Ser Gly Lys Gly Met Leu Met Leu Ser Gly Gly Ile Asp Ser Pro Val 
            180                 185                 190         

Ala Gly Tyr Leu Ala Leu Lys Arg Gly Val Asp Ile Glu Ala Val His 
        195                 200                 205             

Phe Ala Ser Pro Pro Tyr Thr Ser Pro Gly Ala Leu Lys Lys Ala Gln 
    210                 215                 220                 

Asp Leu Thr Arg Lys Leu Thr Lys Phe Gly Gly Asn Ile Gln Phe Ile 
225                 230                 235                 240 

Glu Val Pro Phe Thr Glu Ile Gln Glu Glu Ile Lys Ala Lys Ala Pro 
                245                 250                 255     

Glu Ala Tyr Leu Met Thr Leu Thr Arg Arg Phe Met Met Arg Ile Thr 
            260                 265                 270         

Asp Arg Ile Arg Glu Val Arg Asn Gly Leu Val Ile Ile Asn Gly Glu 
        275                 280                 285             

Ser Leu Gly Gln Val Ala Ser Gln Thr Leu Glu Ser Met Lys Ala Ile 
    290                 295                 300                 

Asn Ala Val Thr Asn Thr Pro Ile Ile Arg Pro Val Val Thr Met Asp 
305                 310                 315                 320 

Lys Leu Glu Ile Ile Asp Ile Ala Gln Glu Ile Asp Thr Phe Asp Ile 
                325                 330                 335     

Ser Ile Gln Pro Phe Glu Asp Cys Cys Thr Ile Phe Ala Pro Asp Arg 
            340                 345                 350         

Pro Lys Thr Asn Pro Lys Ile Lys Asn Ala Glu Gln Tyr Glu Ala Arg 
        355                 360                 365             

Met Asp Val Glu Gly Leu Val Glu Arg Ala Val Ala Gly Ile Met Ile 
    370                 375                 380                 

Thr Glu Ile Thr Pro Gln Ala Glu Lys Asp Glu Val Asp Asp Leu Ile 
385                 390                 395                 400 

Asp Asn Leu Leu 
                

<210>   1705
<211>   822
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1705
atgaatcaat cctactttta tctaaaaatg aaagaacaca aactcaaggt tccttataca   60
ggtaaggagc gccgtgtacg tattcttctt cctaaagatt atgagaaaga tacagaccgt   120
tcctatcctg ttgtatactt tcatgacggg caaaatgttt ttaatagcaa agagtctttc   180
attggacatt catggaagat tatcccagct atcaaacgaa atccggatat cagtcgcatg   240
attgtcgttg ctattgacaa tgatggtatg gggcggatga atgagtatgc ggcttggaag   300
ttccaagaat ctcctatccc agggcagcag tttggtggta agggtgtgga gtatgctgag   360
tttgtcatgg aggtggtcaa gccttttatc gatgagacct atcgtacaaa agcagactgc   420
cagcatacgg ctatgattgg ttcctcacta ggaggcaata ttacccagtt tatcggtttg   480
gaataccaag accaaattgg ttgcttgggc gttttttcat ctgcaaactg gctccaccaa   540
gaagccttta accgctattt cgagtgccag aaactatcgc ctgaccagcg catcttcatc   600
tatgtaggaa cagaagaagc agatgataca gacaagacct tgatggatgg caatatcaaa   660
caagcctata tcgactcgtc gctttgctat taccatgatt tgatagcagg gggagtacat   720
ctggataatc ttgtgctaaa agttcagtct ggtgccatcc atagtgaaat cccttggtca   780
gaaaatctac cagattgtct gagatttttt gcagaaaaat gg                      822

<210>   1706
<211>   274
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902829 (e-164)

<400>   1706
Met Asn Gln Ser Tyr Phe Tyr Leu Lys Met Lys Glu His Lys Leu Lys 
1               5                   10                  15      

Val Pro Tyr Thr Gly Lys Glu Arg Arg Val Arg Ile Leu Leu Pro Lys 
            20                  25                  30          

Asp Tyr Glu Lys Asp Thr Asp Arg Ser Tyr Pro Val Val Tyr Phe His 
        35                  40                  45              

Asp Gly Gln Asn Val Phe Asn Ser Lys Glu Ser Phe Ile Gly His Ser 
    50                  55                  60                  

Trp Lys Ile Ile Pro Ala Ile Lys Arg Asn Pro Asp Ile Ser Arg Met 
65                  70                  75                  80  

Ile Val Val Ala Ile Asp Asn Asp Gly Met Gly Arg Met Asn Glu Tyr 
                85                  90                  95      

Ala Ala Trp Lys Phe Gln Glu Ser Pro Ile Pro Gly Gln Gln Phe Gly 
            100                 105                 110         

Gly Lys Gly Val Glu Tyr Ala Glu Phe Val Met Glu Val Val Lys Pro 
        115                 120                 125             

Phe Ile Asp Glu Thr Tyr Arg Thr Lys Ala Asp Cys Gln His Thr Ala 
    130                 135                 140                 

Met Ile Gly Ser Ser Leu Gly Gly Asn Ile Thr Gln Phe Ile Gly Leu 
145                 150                 155                 160 

Glu Tyr Gln Asp Gln Ile Gly Cys Leu Gly Val Phe Ser Ser Ala Asn 
                165                 170                 175     

Trp Leu His Gln Glu Ala Phe Asn Arg Tyr Phe Glu Cys Gln Lys Leu 
            180                 185                 190         

Ser Pro Asp Gln Arg Ile Phe Ile Tyr Val Gly Thr Glu Glu Ala Asp 
        195                 200                 205             

Asp Thr Asp Lys Thr Leu Met Asp Gly Asn Ile Lys Gln Ala Tyr Ile 
    210                 215                 220                 

Asp Ser Ser Leu Cys Tyr Tyr His Asp Leu Ile Ala Gly Gly Val His 
225                 230                 235                 240 

Leu Asp Asn Leu Val Leu Lys Val Gln Ser Gly Ala Ile His Ser Glu 
                245                 250                 255     

Ile Pro Trp Ser Glu Asn Leu Pro Asp Cys Leu Arg Phe Phe Ala Glu 
            260                 265                 270         

Lys Trp 
        

<210>   1707
<211>   333
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1707
atgcatattg aacatcttag ccactggagt ggtcatctta accgtgaaat gtaccttaac   60
cgttatggac atggtgggat tccagttgtg gtctttgctt catcaggtgg tagtcacaac   120
gaatactatg attttggcat gattgatgcc tgtgcttcct ttatcgagga aggccttgtc   180
cagttcttta ccctatctag tttggatagt gagagctggt tggctacttg gaaaaatgct   240
catgaccaag cggaaatgca ccgtgcctac gaacgttatg tgattgagga ggccattctt   300
ttatcaagca caagacaggt tggtttgatg gca                                333

<210>   1708
<211>   111
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902830 (2.E-63)

<400>   1708
Met His Ile Glu His Leu Ser His Trp Ser Gly His Leu Asn Arg Glu 
1               5                   10                  15      

Met Tyr Leu Asn Arg Tyr Gly His Gly Gly Ile Pro Val Val Val Phe 
            20                  25                  30          

Ala Ser Ser Gly Gly Ser His Asn Glu Tyr Tyr Asp Phe Gly Met Ile 
        35                  40                  45              

Asp Ala Cys Ala Ser Phe Ile Glu Glu Gly Leu Val Gln Phe Phe Thr 
    50                  55                  60                  

Leu Ser Ser Leu Asp Ser Glu Ser Trp Leu Ala Thr Trp Lys Asn Ala 
65                  70                  75                  80  

His Asp Gln Ala Glu Met His Arg Ala Tyr Glu Arg Tyr Val Ile Glu 
                85                  90                  95      

Glu Ala Ile Leu Leu Ser Ser Thr Arg Gln Val Gly Leu Met Ala 
            100                 105                 110     

<210>   1709
<211>   429
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1709
ttgtttacgc caccattccc agtcatgggc gacatcatgt ccccattcag caaaccaggc   60
tggaatttgt ttcttgtcaa aggcttcttt gagcttgtaa aaggatggca aaccatcttg   120
ttcccaggct ccaagccccg tacacagcac aatctctgcc tgacggtaac ggtcaataaa   180
ccagccgtcg ttttggttcc aaatataatc tactggcgag ttttggtaaa tagcatcatc   240
gttgtagtaa tcaccgacaa agaaacgtgc gtcgtaaaca ccactgagag caatcacttt   300
ggtaaagaca tctggatgct ggaggaagaa attgagtgca tgataggctc ccatagagca   360
acctgtcgtc atcatgccat caaaccaacc tgtcttgtgc ttgataaaag aatggcctcc   420
tcaatcaca                                                           429

<210>   1710
<211>   143
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1710
Met Phe Thr Pro Pro Phe Pro Val Met Gly Asp Ile Met Ser Pro Phe 
1               5                   10                  15      

Ser Lys Pro Gly Trp Asn Leu Phe Leu Val Lys Gly Phe Phe Glu Leu 
            20                  25                  30          

Val Lys Gly Trp Gln Thr Ile Leu Phe Pro Gly Ser Lys Pro Arg Thr 
        35                  40                  45              

Gln His Asn Leu Cys Leu Thr Val Thr Val Asn Lys Pro Ala Val Val 
    50                  55                  60                  

Leu Val Pro Asn Ile Ile Tyr Trp Arg Val Leu Val Asn Ser Ile Ile 
65                  70                  75                  80  

Val Val Val Ile Thr Asp Lys Glu Thr Cys Val Val Asn Thr Thr Glu 
                85                  90                  95      

Ser Asn His Phe Gly Lys Asp Ile Trp Met Leu Glu Glu Glu Ile Glu 
            100                 105                 110         

Cys Met Ile Gly Ser His Arg Ala Thr Cys Arg His His Ala Ile Lys 
        115                 120                 125             

Pro Thr Cys Leu Val Leu Asp Lys Arg Met Ala Ser Ser Ile Thr 
    130                 135                 140             

<210>   1711
<211>   405
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1711
atgatgacga caggttgctc tatgggagcc tatcatgcac tcaatttctt cctccagcat   60
ccagatgtct ttaccaaagt gattgctctc agtggtgttt acgacgcacg tttctttgtc   120
ggtgattact acaacgatga tgctatttac caaaactcgc cagtagatta tatttggaac   180
caaaacgacg gctggtttat tgaccgttac cgtcaggcag agattgtgct gtgtacgggg   240
cttggagcct gggaacaaga tggtttgcca tccttttaca agctcaaaga agcctttgac   300
aagaaacaaa ttccagcctg gtttgctgaa tggggacatg atgtcgccca tgactgggaa   360

tggtggcgta aacaaatgcc ttatttcctc ggtaatctct attta                   405

<210>   1712
<211>   135
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902832 (5.E-84)

<400>   1712
Met Met Thr Thr Gly Cys Ser Met Gly Ala Tyr His Ala Leu Asn Phe 
1               5                   10                  15      

Phe Leu Gln His Pro Asp Val Phe Thr Lys Val Ile Ala Leu Ser Gly 
            20                  25                  30          

Val Tyr Asp Ala Arg Phe Phe Val Gly Asp Tyr Tyr Asn Asp Asp Ala 
        35                  40                  45              

Ile Tyr Gln Asn Ser Pro Val Asp Tyr Ile Trp Asn Gln Asn Asp Gly 
    50                  55                  60                  

Trp Phe Ile Asp Arg Tyr Arg Gln Ala Glu Ile Val Leu Cys Thr Gly 
65                  70                  75                  80  

Leu Gly Ala Trp Glu Gln Asp Gly Leu Pro Ser Phe Tyr Lys Leu Lys 
                85                  90                  95      

Glu Ala Phe Asp Lys Lys Gln Ile Pro Ala Trp Phe Ala Glu Trp Gly 
            100                 105                 110         

His Asp Val Ala His Asp Trp Glu Trp Trp Arg Lys Gln Met Pro Tyr 
        115                 120                 125             

Phe Leu Gly Asn Leu Tyr Leu 
    130                 135 

<210>   1713
<211>   1164
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1713
atgaattacc ttgttatttc tccctactat ccacaaaact ttcaacagtt taccatcgaa   60
ctagctaata aaggcatcac agtcttggga attggtcaag agtcttacga gcaattggat   120
gagcccttgc gcaatagctt gaccgagtat tttcgtgttg ataatcttga gaacatagat   180
gaagtcaaac gtgcagttgc ttttctcttt tataaacatg gtccaattgg ccgcatcgag   240
tctcacaatg aatactggct tgagctagac gcaacactca gagaacaatt caatgttttt   300
ggtgccaaac cagaggatct caaaaagacg aaatataagt ctgaaatgaa gaaacttttc   360
aaaaaagcag gtgttcctgt ggtacctgga gctgttatca agacggaagc agatgttgat   420
caagcagtga aagaaatcgg tcttccaatg attgccaaac ctgataatgg agtgggagca   480
gccgcaacct ttaaacttga gacagaagac gatatcaatc acttcaagca agaatgggac   540
cattcaaccc tttatttctt tgaaaaattt gtcacttcca gcgaaatctg tacctttgac   600
gggctcgtgg acaaggatgg aaagattgtc ttctcaacaa cctttgacta cgcctataca   660
ccgcttgacc tcatgattta taagatggac aattcttatt atgtgctcaa ggatatggat   720

cctaaactgc gcaagtatgg ggaagcaatt gtcaaagaat ttggtatgaa agaacggttt   780
ttccatattg agttcttccg tgagggggac gattatatta ccatcgagta caataaccgc   840
cctgcaggtg gttttaccat tgatgtttat aactttgctc attccttgga cctttatcgt   900
ggctatgcag ctattgtcgc aggagaggag ttcccggcgt cagactttga aactcagtat   960
tgtttggcta cttctcgccg tgcaaatgct cactatgttt attcagaaga ggatttgctt   1020
gccaaatata gccagcagtt caaggttaaa aaagtcatgc cagctgcctt cgcggaactt   1080
caaggagatt acctgtatat gctgaccact ccgagtcgac aagaaatgga gcagatgatt   1140
gcagatttcg gacaacgtca agaa                                          1164

<210>   1714
<211>   388
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902833 (0.E+01)

<400>   1714
Met Asn Tyr Leu Val Ile Ser Pro Tyr Tyr Pro Gln Asn Phe Gln Gln 
1               5                   10                  15      

Phe Thr Ile Glu Leu Ala Asn Lys Gly Ile Thr Val Leu Gly Ile Gly 
            20                  25                  30          

Gln Glu Ser Tyr Glu Gln Leu Asp Glu Pro Leu Arg Asn Ser Leu Thr 
        35                  40                  45              

Glu Tyr Phe Arg Val Asp Asn Leu Glu Asn Ile Asp Glu Val Lys Arg 
    50                  55                  60                  

Ala Val Ala Phe Leu Phe Tyr Lys His Gly Pro Ile Gly Arg Ile Glu 
65                  70                  75                  80  

Ser His Asn Glu Tyr Trp Leu Glu Leu Asp Ala Thr Leu Arg Glu Gln 
                85                  90                  95      

Phe Asn Val Phe Gly Ala Lys Pro Glu Asp Leu Lys Lys Thr Lys Tyr 
            100                 105                 110         

Lys Ser Glu Met Lys Lys Leu Phe Lys Lys Ala Gly Val Pro Val Val 
        115                 120                 125             

Pro Gly Ala Val Ile Lys Thr Glu Ala Asp Val Asp Gln Ala Val Lys 
    130                 135                 140                 

Glu Ile Gly Leu Pro Met Ile Ala Lys Pro Asp Asn Gly Val Gly Ala 
145                 150                 155                 160 

Ala Ala Thr Phe Lys Leu Glu Thr Glu Asp Asp Ile Asn His Phe Lys 
                165                 170                 175     

Gln Glu Trp Asp His Ser Thr Leu Tyr Phe Phe Glu Lys Phe Val Thr 
            180                 185                 190         

Ser Ser Glu Ile Cys Thr Phe Asp Gly Leu Val Asp Lys Asp Gly Lys 
        195                 200                 205             

Ile Val Phe Ser Thr Thr Phe Asp Tyr Ala Tyr Thr Pro Leu Asp Leu 
    210                 215                 220                 

Met Ile Tyr Lys Met Asp Asn Ser Tyr Tyr Val Leu Lys Asp Met Asp 
225                 230                 235                 240 

Pro Lys Leu Arg Lys Tyr Gly Glu Ala Ile Val Lys Glu Phe Gly Met 
                245                 250                 255     

Lys Glu Arg Phe Phe His Ile Glu Phe Phe Arg Glu Gly Asp Asp Tyr 
            260                 265                 270         

Ile Thr Ile Glu Tyr Asn Asn Arg Pro Ala Gly Gly Phe Thr Ile Asp 
        275                 280                 285             

Val Tyr Asn Phe Ala His Ser Leu Asp Leu Tyr Arg Gly Tyr Ala Ala 
    290                 295                 300                 

Ile Val Ala Gly Glu Glu Phe Pro Ala Ser Asp Phe Glu Thr Gln Tyr 
305                 310                 315                 320 

Cys Leu Ala Thr Ser Arg Arg Ala Asn Ala His Tyr Val Tyr Ser Glu 
                325                 330                 335     

Glu Asp Leu Leu Ala Lys Tyr Ser Gln Gln Phe Lys Val Lys Lys Val 
            340                 345                 350         

Met Pro Ala Ala Phe Ala Glu Leu Gln Gly Asp Tyr Leu Tyr Met Leu 
        355                 360                 365             

Thr Thr Pro Ser Arg Gln Glu Met Glu Gln Met Ile Ala Asp Phe Gly 
    370                 375                 380                 

Gln Arg Gln Glu 
385             

<210>   1715
<211>   156
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1715
atgaaaatca aagagcaaac taggaagcta gccgcaggtt tctcaaaaca ctgttttgag   60
gttgtggata gaactgacag agtcagtatc atatactacg gcaaggtgaa gctgacgtgg   120
tttgaagaga ttttcgaaga gtataaaata ttcagg                             156

<210>   1716
<211>   52
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1716
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Phe Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Arg Thr Asp Arg Val Ser Ile Ile Tyr 
            20                  25                  30          

Tyr Gly Lys Val Lys Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr 
        35                  40                  45              

Lys Ile Phe Arg 
    50          

<210>   1717
<211>   1491
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1717
atgattacag gcgaattaaa aaataaaatc gatcagctgt gggaaattct ttggacagaa   60
ggaaacgcaa atcctttaac aaatattgaa cagttgactt atctcttatt tatgaaagat   120
ttggatagtg tcgagcttgg acgtgaaagt gatgctgaat ttctagggat tccttatgag   180
ggagtttttc caaaagataa acctgaatac cgttggtcaa cttttaaaaa tataggagat   240
gctcaggaag tttatcgttt aatgactcag gagatttttc cgtttattaa aaatctcaag   300
ggggatacag atgatacagc cttttcacga tatatgcgag aagctatttt tcaaataaat   360
aaacctgcta cgcttcaaaa ggcaatttct atcttagatg tttttccaac taggggatta   420
gatgtagatt ttgataatga caaacaaagt attactgata tcggagatat ctatgaatat   480
ctgttatcaa aattgtcgac cgcaggtaaa aatggacagt tccgtacacc tcgtcacatc   540
atcgatatga tggttgagtt gatgcaaccg actatcaaag atatcatctc agatcccgct   600
atgggttctg ctggcttctt agtatctgct agccgttact taaagcgtaa gaaagatgaa   660
tgggaaacca atacagataa tatcaatcat tttcataatc agatgtttca tggaaatgat   720
acggatacga ctatgttgag acttggggcg atgaacatga tgctacatgg agtagaaaat   780
ccacaaatca gttaccttga ctcgctgtct caagataatg aagaagccga taaatatact   840
ttggttttag caaatcctcc ttttaagggc tcacttgact acaattcaac ctctaatgac   900
cttcttgcaa ccgtaaaaac caaaaaaaca gaattactct ttctttctct tttcttgcga   960
actttaaaac caggtggacg agcagcagtt atcgtacctg atggtgtcct ttttggttcg   1020
tctaaagctc ataaaggaat tcgtcaggaa attgtagaga atcataagct tgatgctgta   1080
atctcaatgc ctagtggtgt gttcaagcct tatgctggag tttcaactgc cattctcatc   1140
tttacaaaaa ctggtaatgg tggtactgac aaagtctggt tttacgatat gaaagcggat   1200
ggtttaagtt tggatgataa gcgacaaccg attagcgaca atgatattcc agatattatc   1260
gaacgctttc atcatcttga aaaagaagca gaacgtcaga gaacggatca atctttcttt   1320
gttccagttg ctgagataaa ggaaaatgat tatgatttgt ctatcaataa atataaagag   1380
attgagtatg aaaaagttga gtatgaacca acagaagtca tattaaagaa aatcaatgat   1440
ttagaaaaag aaattcaagc tggcttggct gaattggaaa aattactcaa g            1491

<210>   1718
<211>   497
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type I restriction-modification system, M subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902834 (0.E+01)

<400>   1718
Met Ile Thr Gly Glu Leu Lys Asn Lys Ile Asp Gln Leu Trp Glu Ile 
1               5                   10                  15      

Leu Trp Thr Glu Gly Asn Ala Asn Pro Leu Thr Asn Ile Glu Gln Leu 
            20                  25                  30          

Thr Tyr Leu Leu Phe Met Lys Asp Leu Asp Ser Val Glu Leu Gly Arg 
        35                  40                  45              

Glu Ser Asp Ala Glu Phe Leu Gly Ile Pro Tyr Glu Gly Val Phe Pro 
    50                  55                  60                  

Lys Asp Lys Pro Glu Tyr Arg Trp Ser Thr Phe Lys Asn Ile Gly Asp 
65                  70                  75                  80  

Ala Gln Glu Val Tyr Arg Leu Met Thr Gln Glu Ile Phe Pro Phe Ile 
                85                  90                  95      

Lys Asn Leu Lys Gly Asp Thr Asp Asp Thr Ala Phe Ser Arg Tyr Met 
            100                 105                 110         

Arg Glu Ala Ile Phe Gln Ile Asn Lys Pro Ala Thr Leu Gln Lys Ala 
        115                 120                 125             

Ile Ser Ile Leu Asp Val Phe Pro Thr Arg Gly Leu Asp Val Asp Phe 
    130                 135                 140                 

Asp Asn Asp Lys Gln Ser Ile Thr Asp Ile Gly Asp Ile Tyr Glu Tyr 
145                 150                 155                 160 

Leu Leu Ser Lys Leu Ser Thr Ala Gly Lys Asn Gly Gln Phe Arg Thr 
                165                 170                 175     

Pro Arg His Ile Ile Asp Met Met Val Glu Leu Met Gln Pro Thr Ile 
            180                 185                 190         

Lys Asp Ile Ile Ser Asp Pro Ala Met Gly Ser Ala Gly Phe Leu Val 
        195                 200                 205             

Ser Ala Ser Arg Tyr Leu Lys Arg Lys Lys Asp Glu Trp Glu Thr Asn 
    210                 215                 220                 

Thr Asp Asn Ile Asn His Phe His Asn Gln Met Phe His Gly Asn Asp 
225                 230                 235                 240 

Thr Asp Thr Thr Met Leu Arg Leu Gly Ala Met Asn Met Met Leu His 
                245                 250                 255     

Gly Val Glu Asn Pro Gln Ile Ser Tyr Leu Asp Ser Leu Ser Gln Asp 
            260                 265                 270         

Asn Glu Glu Ala Asp Lys Tyr Thr Leu Val Leu Ala Asn Pro Pro Phe 
        275                 280                 285             

Lys Gly Ser Leu Asp Tyr Asn Ser Thr Ser Asn Asp Leu Leu Ala Thr 
    290                 295                 300                 

Val Lys Thr Lys Lys Thr Glu Leu Leu Phe Leu Ser Leu Phe Leu Arg 
305                 310                 315                 320 

Thr Leu Lys Pro Gly Gly Arg Ala Ala Val Ile Val Pro Asp Gly Val 
                325                 330                 335     

Leu Phe Gly Ser Ser Lys Ala His Lys Gly Ile Arg Gln Glu Ile Val 
            340                 345                 350         

Glu Asn His Lys Leu Asp Ala Val Ile Ser Met Pro Ser Gly Val Phe 
        355                 360                 365             

Lys Pro Tyr Ala Gly Val Ser Thr Ala Ile Leu Ile Phe Thr Lys Thr 
    370                 375                 380                 

Gly Asn Gly Gly Thr Asp Lys Val Trp Phe Tyr Asp Met Lys Ala Asp 
385                 390                 395                 400 

Gly Leu Ser Leu Asp Asp Lys Arg Gln Pro Ile Ser Asp Asn Asp Ile 
                405                 410                 415     

Pro Asp Ile Ile Glu Arg Phe His His Leu Glu Lys Glu Ala Glu Arg 
            420                 425                 430         

Gln Arg Thr Asp Gln Ser Phe Phe Val Pro Val Ala Glu Ile Lys Glu 
        435                 440                 445             

Asn Asp Tyr Asp Leu Ser Ile Asn Lys Tyr Lys Glu Ile Glu Tyr Glu 
    450                 455                 460                 

Lys Val Glu Tyr Glu Pro Thr Glu Val Ile Leu Lys Lys Ile Asn Asp 
465                 470                 475                 480 

Leu Glu Lys Glu Ile Gln Ala Gly Leu Ala Glu Leu Glu Lys Leu Leu 
                485                 490                 495     

Lys 
    

<210>   1719
<211>   1119
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1719
atgaaaaaag tgaagttggg ggaagtctta tctctaaaaa aaggcaagaa agccactgta   60
cttgctgaac aaacaactct aagccaacgt tatattcaaa tagatgattt aagaaataat   120
aataatttaa aattcactga aagtttaaat atgactgaag cactcccaga tgatattctg   180
atagcatggg atggagctaa tgcaggaaca gttggttatg gattatcggg agctgttggt   240
agtacaatta cggtcttaaa aaagaatgag cgatacaaag aaaaaattat atcagattac   300
ttgggagtct ttttggaaag taaatcgcag tatttacgag atcattcaac aggtgcaaca   360
attcctcatt taaacaagaa tatattactt gatttacaat tagaattgct aggtatcgaa   420
gaacaagaga acattatctg tattcttaat acgattaaaa ggcttattac taaaagaaaa   480
tttcagttag atgaactaaa cttgctcgtc aaatcccgat ttaacgagat gtttggggaa   540
aataaaatat ttgaaagcat tgataactta tttgatatta tagatggtga taggggcaaa   600
aattatccta aatcagatga gttgtttagt gaggagtact gtttattttt aaatacaaag   660
aatgttacta aaaacggatt ttcattcgat acaaagcaat ttatcactaa aacaaaggat   720
aaattacttc gaaaaggcaa acttgagcgt tatgatatag tcttgacaac aagaggtact   780
gttggaaatg tagcgtacta cgatgaatta ataaaatata aacatttacg tataaattca   840
ggtatggtaa tattacgtcc caagacacca aatctaaatc agaaatttat tatccatgtt   900
ttaaggaata ataattatag tcgagtgata tcaggaagtg ctcagcctca gttaccaatt   960
acaaaattaa aaaaaatact tctccccctc cccccactag ccctccaaaa tgagttcgca   1020
gactttgtag tccaggtcga caaatcacaa ttggcaatcc aaaaatctct ggaagaactt   1080
gaaactttga agaaatctct gatgcaggag tattttggc                          1119

<210>   1720
<211>   373
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type I restriction-modification system, S subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902835 (1.E-96)

<400>   1720
Met Lys Lys Val Lys Leu Gly Glu Val Leu Ser Leu Lys Lys Gly Lys 
1               5                   10                  15      

Lys Ala Thr Val Leu Ala Glu Gln Thr Thr Leu Ser Gln Arg Tyr Ile 
            20                  25                  30          

Gln Ile Asp Asp Leu Arg Asn Asn Asn Asn Leu Lys Phe Thr Glu Ser 
        35                  40                  45              

Leu Asn Met Thr Glu Ala Leu Pro Asp Asp Ile Leu Ile Ala Trp Asp 
    50                  55                  60                  

Gly Ala Asn Ala Gly Thr Val Gly Tyr Gly Leu Ser Gly Ala Val Gly 
65                  70                  75                  80  

Ser Thr Ile Thr Val Leu Lys Lys Asn Glu Arg Tyr Lys Glu Lys Ile 
                85                  90                  95      

Ile Ser Asp Tyr Leu Gly Val Phe Leu Glu Ser Lys Ser Gln Tyr Leu 
            100                 105                 110         

Arg Asp His Ser Thr Gly Ala Thr Ile Pro His Leu Asn Lys Asn Ile 
        115                 120                 125             


Leu Leu Asp Leu Gln Leu Glu Leu Leu Gly Ile Glu Glu Gln Glu Asn 
    130                 135                 140                 

Ile Ile Cys Ile Leu Asn Thr Ile Lys Arg Leu Ile Thr Lys Arg Lys 
145                 150                 155                 160 

Phe Gln Leu Asp Glu Leu Asn Leu Leu Val Lys Ser Arg Phe Asn Glu 
                165                 170                 175     

Met Phe Gly Glu Asn Lys Ile Phe Glu Ser Ile Asp Asn Leu Phe Asp 
            180                 185                 190         

Ile Ile Asp Gly Asp Arg Gly Lys Asn Tyr Pro Lys Ser Asp Glu Leu 
        195                 200                 205             

Phe Ser Glu Glu Tyr Cys Leu Phe Leu Asn Thr Lys Asn Val Thr Lys 
    210                 215                 220                 

Asn Gly Phe Ser Phe Asp Thr Lys Gln Phe Ile Thr Lys Thr Lys Asp 
225                 230                 235                 240 

Lys Leu Leu Arg Lys Gly Lys Leu Glu Arg Tyr Asp Ile Val Leu Thr 
                245                 250                 255     

Thr Arg Gly Thr Val Gly Asn Val Ala Tyr Tyr Asp Glu Leu Ile Lys 
            260                 265                 270         

Tyr Lys His Leu Arg Ile Asn Ser Gly Met Val Ile Leu Arg Pro Lys 
        275                 280                 285             

Thr Pro Asn Leu Asn Gln Lys Phe Ile Ile His Val Leu Arg Asn Asn 
    290                 295                 300                 

Asn Tyr Ser Arg Val Ile Ser Gly Ser Ala Gln Pro Gln Leu Pro Ile 
305                 310                 315                 320 

Thr Lys Leu Lys Lys Ile Leu Leu Pro Leu Pro Pro Leu Ala Leu Gln 
                325                 330                 335     

Asn Glu Phe Ala Asp Phe Val Val Gln Val Asp Lys Ser Gln Leu Ala 
            340                 345                 350         

Ile Gln Lys Ser Leu Glu Glu Leu Glu Thr Leu Lys Lys Ser Leu Met 
        355                 360                 365             

Gln Glu Tyr Phe Gly 
    370             

<210>   1721
<211>   234
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1721
atggtagtaa aaacaagaaa acaaggaaat tcaatcacca ttacgattcc aagtgaattt   60
aatattccaa gtggtgttaa atacgaagcg aaattgttac caagtggtga gattatcttt   120
actcctgaag aattggggca gcaggtttct tatgtatctg atgatgcctt tgacttaaat   180
ttagataaaa tatttgacga atacgacgat gttttcaaag ctttggtgga aaaa         234

<210>   1722
<211>   78
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1722
Met Val Val Lys Thr Arg Lys Gln Gly Asn Ser Ile Thr Ile Thr Ile 
1               5                   10                  15      

Pro Ser Glu Phe Asn Ile Pro Ser Gly Val Lys Tyr Glu Ala Lys Leu 
            20                  25                  30          

Leu Pro Ser Gly Glu Ile Ile Phe Thr Pro Glu Glu Leu Gly Gln Gln 
        35                  40                  45              

Val Ser Tyr Val Ser Asp Asp Ala Phe Asp Leu Asn Leu Asp Lys Ile 
    50                  55                  60                  

Phe Asp Glu Tyr Asp Asp Val Phe Lys Ala Leu Val Glu Lys 
65                  70                  75              

<210>   1723
<211>   411
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1723
atgacaatct atttgacaga aaagcaaatt gaaaaaataa atgctttagc aattcaacgg   60
tattctccaa atgagaaaat tcaaacagtt agtccttctg ccttaaatat gattgtgaac   120
ttaccagaac aatttgtctt tgggaagcct ctttatccaa caatttttga taaagcaacg   180
atactatttg tccaattgat aaagaagcat gtttttgcta atgctaataa aagaactgct   240
ttcttcgttt tggtcaaatt tttacaatta aacggctatc gtttttctgt aacggtagaa   300
gaagcagtaa aaatgtgtgt aaccatcgca gtagaagctt taactgatga aaaaatgaca   360
agctactcca aatggatttc tgaacattct gttagagaaa aggtcaaaaa g            411

<210>   1724
<211>   137
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1724
Met Thr Ile Tyr Leu Thr Glu Lys Gln Ile Glu Lys Ile Asn Ala Leu 
1               5                   10                  15      

Ala Ile Gln Arg Tyr Ser Pro Asn Glu Lys Ile Gln Thr Val Ser Pro 
            20                  25                  30          

Ser Ala Leu Asn Met Ile Val Asn Leu Pro Glu Gln Phe Val Phe Gly 
        35                  40                  45              

Lys Pro Leu Tyr Pro Thr Ile Phe Asp Lys Ala Thr Ile Leu Phe Val 
    50                  55                  60                  

Gln Leu Ile Lys Lys His Val Phe Ala Asn Ala Asn Lys Arg Thr Ala 
65                  70                  75                  80  

Phe Phe Val Leu Val Lys Phe Leu Gln Leu Asn Gly Tyr Arg Phe Ser 
                85                  90                  95      

Val Thr Val Glu Glu Ala Val Lys Met Cys Val Thr Ile Ala Val Glu 
            100                 105                 110         

Ala Leu Thr Asp Glu Lys Met Thr Ser Tyr Ser Lys Trp Ile Ser Glu 
        115                 120                 125             

His Ser Val Arg Glu Lys Val Lys Lys 
    130                 135         

<210>   1725
<211>   963
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1725
atggaatcaa aagttacaat tatcatgcaa gaaatgttac ctcttttaaa taatgaacaa   60
ttactagcgt tgagagagag tttagaacat catctagtag acggaaaaaa gcagcagaag   120
tattcgaata ataacctgtt gcaactattt attaccgcca agcaggtaga gggctgtagc   180
tcaaaaacaa ttcgttatta tcagaggacg attgaaaact tgtttaatgc tattaaagag   240
tctgtgacac aactcacaac agatgattta aggagttatt tagcaaatta ccagtctgaa   300
aaggattgta gtaaggcaaa tttagacaat attaggcgta tattgtcttc tttttttgct   360
tggcttgagc aagaggaata tatcattaaa aatcccattc gacggataaa gaaaattaag   420
actgagcaaa atgtgaagga aacttatact gatgaacatt tggaaattat gcgtgataac   480
tgtgaaaatt tgagagattt ggcaataata gacctactag catcgacagg tatgcgtgta   540
ggggagcttg tacagttgaa tcgttcagat attgattttg aaaacagaga gtgtgttgtc   600
tttggtaaag gaaagaagga gagaccagta tattttgacg ctcgtacgaa aattcattta   660
agaaattatc ttaacgacag aaaagatagt caccctgctc tttttgtaac gctagttgga   720
aaagtccaga ggcttggaat tgctggtgta gagattcgct taagaaagtt aggagacaaa   780
ctcggcatac aaaaggttca cccacataag ttcagaagaa ctttagcgac taaggcaatt   840
gataaaggta tgcctatcga acaagtccaa aaactgctag gtcatagcaa gattgacaca   900
accttggcct atgccatggt caatcaaaat aatgtcaagc attcacacca aaaattcatc   960
tct                                                                 963

<210>   1726
<211>   321
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   integrase/recombinase, phage integrase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903090 (4.E-14)

<400>   1726
Met Glu Ser Lys Val Thr Ile Ile Met Gln Glu Met Leu Pro Leu Leu 

1               5                   10                  15      

Asn Asn Glu Gln Leu Leu Ala Leu Arg Glu Ser Leu Glu His His Leu 
            20                  25                  30          

Val Asp Gly Lys Lys Gln Gln Lys Tyr Ser Asn Asn Asn Leu Leu Gln 
        35                  40                  45              

Leu Phe Ile Thr Ala Lys Gln Val Glu Gly Cys Ser Ser Lys Thr Ile 
    50                  55                  60                  

Arg Tyr Tyr Gln Arg Thr Ile Glu Asn Leu Phe Asn Ala Ile Lys Glu 
65                  70                  75                  80  

Ser Val Thr Gln Leu Thr Thr Asp Asp Leu Arg Ser Tyr Leu Ala Asn 
                85                  90                  95      

Tyr Gln Ser Glu Lys Asp Cys Ser Lys Ala Asn Leu Asp Asn Ile Arg 
            100                 105                 110         

Arg Ile Leu Ser Ser Phe Phe Ala Trp Leu Glu Gln Glu Glu Tyr Ile 
        115                 120                 125             

Ile Lys Asn Pro Ile Arg Arg Ile Lys Lys Ile Lys Thr Glu Gln Asn 
    130                 135                 140                 

Val Lys Glu Thr Tyr Thr Asp Glu His Leu Glu Ile Met Arg Asp Asn 
145                 150                 155                 160 

Cys Glu Asn Leu Arg Asp Leu Ala Ile Ile Asp Leu Leu Ala Ser Thr 
                165                 170                 175     

Gly Met Arg Val Gly Glu Leu Val Gln Leu Asn Arg Ser Asp Ile Asp 
            180                 185                 190         

Phe Glu Asn Arg Glu Cys Val Val Phe Gly Lys Gly Lys Lys Glu Arg 
        195                 200                 205             

Pro Val Tyr Phe Asp Ala Arg Thr Lys Ile His Leu Arg Asn Tyr Leu 
    210                 215                 220                 

Asn Asp Arg Lys Asp Ser His Pro Ala Leu Phe Val Thr Leu Val Gly 
225                 230                 235                 240 

Lys Val Gln Arg Leu Gly Ile Ala Gly Val Glu Ile Arg Leu Arg Lys 
                245                 250                 255     

Leu Gly Asp Lys Leu Gly Ile Gln Lys Val His Pro His Lys Phe Arg 
            260                 265                 270         

Arg Thr Leu Ala Thr Lys Ala Ile Asp Lys Gly Met Pro Ile Glu Gln 
        275                 280                 285             

Val Gln Lys Leu Leu Gly His Ser Lys Ile Asp Thr Thr Leu Ala Tyr 
    290                 295                 300                 

Ala Met Val Asn Gln Asn Asn Val Lys His Ser His Gln Lys Phe Ile 
305                 310                 315                 320 

Ser 
    

<210>   1727
<211>   657
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1727
atgccatggt caatcaaaat aatgtcaagc attcacacca aaaattcatc tcttaaaagc   60
aaatcccgat ttaacgagat gtttggggaa aataaaatat ttgaaagcat tgataactta   120
tttgatatta tagatggtga taggggcaaa aattatccta aatcagatga gttgtttagt   180
gaggagtact gtttattttt aaatacaaag aatgttacta aaaacggatt ttcattcgat   240
acaaagcaat ttatcactaa aacaaaggat aaattacttc gaaaaggcaa acttgagcgt   300
tatgatatag tcttgacaac aagaggtact gttggaaatg tagcgtacta cgatgaatta   360
ataaaatata aacatttacg tataaattca ggtatggtaa tattacgtcc caagacacca   420
aatctaaatc agaaatttat tatccatgtt ttaaggaata ataattatag tcgagtgata   480
tcaggaagtg ctcagcctca gttaccaatt acaaaattaa aaaaaatact tctccccctc   540
cccccactag ccctccaaaa tgagttcgca gactttgtag tccaggtcga caaatcacaa   600
tttgcttgtg agatagctat aaaagtgtgg agaaatagct tgaaatttag tataata      657

<210>   1728
<211>   219
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type I restriction-modification system, S subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902492 (9.E-07)

<400>   1728
Met Pro Trp Ser Ile Lys Ile Met Ser Ser Ile His Thr Lys Asn Ser 
1               5                   10                  15      

Ser Leu Lys Ser Lys Ser Arg Phe Asn Glu Met Phe Gly Glu Asn Lys 
            20                  25                  30          

Ile Phe Glu Ser Ile Asp Asn Leu Phe Asp Ile Ile Asp Gly Asp Arg 
        35                  40                  45              

Gly Lys Asn Tyr Pro Lys Ser Asp Glu Leu Phe Ser Glu Glu Tyr Cys 
    50                  55                  60                  

Leu Phe Leu Asn Thr Lys Asn Val Thr Lys Asn Gly Phe Ser Phe Asp 
65                  70                  75                  80  

Thr Lys Gln Phe Ile Thr Lys Thr Lys Asp Lys Leu Leu Arg Lys Gly 
                85                  90                  95      

Lys Leu Glu Arg Tyr Asp Ile Val Leu Thr Thr Arg Gly Thr Val Gly 
            100                 105                 110         

Asn Val Ala Tyr Tyr Asp Glu Leu Ile Lys Tyr Lys His Leu Arg Ile 
        115                 120                 125             

Asn Ser Gly Met Val Ile Leu Arg Pro Lys Thr Pro Asn Leu Asn Gln 
    130                 135                 140                 

Lys Phe Ile Ile His Val Leu Arg Asn Asn Asn Tyr Ser Arg Val Ile 
145                 150                 155                 160 

Ser Gly Ser Ala Gln Pro Gln Leu Pro Ile Thr Lys Leu Lys Lys Ile 
                165                 170                 175     

Leu Leu Pro Leu Pro Pro Leu Ala Leu Gln Asn Glu Phe Ala Asp Phe 
            180                 185                 190         

Val Val Gln Val Asp Lys Ser Gln Phe Ala Cys Glu Ile Ala Ile Lys 
        195                 200                 205             

Val Trp Arg Asn Ser Leu Lys Phe Ser Ile Ile 
    210                 215                 

<210>   1729
<211>   3348
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1729
atgggaaatt ttagctttct tttaaaaaat gacgaatatg aatctttttc aaaaccttgc   60
attgaagctg agaatatgat tgctacatca actgtggcta ctgcctttat ggcgcgtcgt   120
gctttagagc aggctgtcca ttggatatat agtcacgatt catatttaga agctccctat   180
cgtgctactc tatcttcttt agtatgggat gatgatttta gggatatcgt agattctgaa   240
ctccacaagc agatagttct gttgattcgg tggggaaacc atgctgctca tggtggtgaa   300
attaaggaac gagaagcgat tttagctttg catcatttgt atcagtttgt taattttatc   360
gattattgtt acagcaatga gtttgtggag cgttattttg atgagaagtg cttaccactt   420
tcagcaaaca tcaaataccg agaaactcca caatctatga taaagttaca agacagttta   480
ccagaactgc ctgattttca tgaacagatg gctgctcagt ccgtagaagt tcaagagact   540
tatactgaaa aacgtgagac tgcagcgcaa cggcaagatg tgcctttcca tattgatcaa   600
ttatctgagg cagagacaag aaagctcttt attgatatcg atctccgttt agcaggatgg   660
atatttgaag aaaactgtcg tgttgagata gccgttgatg gtctcaagca cggttcagga   720
attggttact gtgactatgt actttatggt aaaaatggga aaattttagc gattgtggag   780
gctaaaaaag cctctgtcaa tccagaagta ggggaagtac aggtcaaaga atatgctgaa   840
gctttggaga aacatatcgg ctatcagcca atttgcttta ttacaaatgg gttgaagcac   900
tatatacttg atggtccgaa ccgccgccag attgcaggct tttactctca agaagaattg   960
caattagtga tggatagacg tcatcttcaa aaaccgcttg aggatatttc tagtaaaatt   1020
agggacgata tttccgggcg tcactaccaa aaacatgcca ttgcaagcgt ttgtgaagct   1080
ttctctgatc atcgtagaca ggcacttttg gttatggcaa ctggggcggg gaaaactcgt   1140
acagcagttt ctctagttga tatcttatca cgtcataact gggtaaaaaa cgttctcttc   1200
ttagccgata gaacttcctt ggttaagcaa gcatatgatt cgtttagaaa attactccca   1260
gatctttccg tttgtaactt cttagaagat aaagaaggag ctcaatcaag tcgcatggtc   1320
ttttcaactt atccgaccat gattggagcg attagtggtc aagaagaagt aaatcaacgc   1380
cctttcactg ttgggcattt tgaccttatc ataattgacg aatctcaccg ttctatttat   1440
cagaaataca agtccatttt tgattatttt gatgcaagaa ttgtaggctt aacagctact   1500
ccgcgtcaag atttagataa aaacacctat ggattcttta atttggagaa tggggttcca   1560
acatatgcat atgatttgga agaggctgtt aaagacggat atttagtagc ctatcattct   1620
atcgaaacca aactgaaact acctacggat ggtctacatt atgatgattt gtccgaagaa   1680
gaaaaggaac attttgatag caaatttgaa gacaatagct gtgaaaaaga tattgatggg   1740
agtgtattta attcctttat tttcaataaa agtacagtag aaattgtttt aaatgaactc   1800
atgacaagag gaattcagac agcctcgggt gatgaaattg gtaaaactat tatttttgct   1860
aaaaatcatg atcatgcgga atatatcaga ggtattttta acaaccgcta tcctgaaaaa   1920
gggagcgact atgctcaggt gattgattat agtattaagc attatcagac cttgattgat   1980
gattttaaaa ttaaggagaa gtatcctcaa attgcgattt ctgtcgatat gttagataca   2040
ggtattgatg taccagaggt tgttaattta gtcttcttca agaaagtacg ctctaaaact   2100
aagttttggc agatgattgg tcgaggaacc cgtctatgta aagatttatt tggacctgag   2160
caggataagg aaaacttctt ggtatttgat tatggggaca attttgatta ttttcgtgca   2220
gatccaagag atggagaggg tcgtcacatt gtttcgctga ctcagcgttt atttaatatc   2280
aaagtggact tgattcgaga acttcaggga ctccaatacc aagaagatca gtttgcgaga   2340
gcataccgtc agcagcttgt ctcggaactt caaggtcgta tagagagctt aaatgagttg   2400
gacttcaggg ttcgtatggt tttagataca gtttatagct ataggaaatt ggaaagttgg   2460
cagaatctaa ctgctgttac aagtgaaacc attcaaaaaa atctctctcc gcttttattt   2520
gatgaagata aagaagatga gatggcgagg agatttgatt tgtggttgct tcatattcag   2580
ttggggcaac tgacagctaa atcttccact gttcatattt cccaagtgat gaagacggct   2640
agagctcttt ctgctattgg caatatcccg caggtttttg agcaggctga aattatcagg   2700
aaagtacagg agcctgaatt ttggaaagaa gttaacttgt ctgatttgga aaaaattcgt   2760
cttgctattc gagatttatt acagtttttg gataaaacag accgtaaacc ctactatgtt   2820
aactttgaag atcgtatact ctccactgtt cacgagacca cagcattttt gcaggtcaac   2880
gatcttcggt cttacaatga aaaagttgag cattatttga aaactcatct ggatgaggag   2940
tccatttcta agctatacca taataaaaag ttgacatctg atgatatgct tgcacttgaa   3000
aaattgcttt gggaaaaatt aggtagtaaa gcagactacc aaagtcatta tgaaaataag   3060
gcaattccga gattggttcg tgagattatt ggcttagata gagagtctgc caatcgtatt   3120
ttttctaaat ttttgtcgga tgagaatctt aatgccaggc agatttcatt tgtaaaattg   3180
attgtagact acattgtaga aaatggtttt ttagagacga aagtgttaac gcaagagccg   3240
tttaaatctt atggttctgt tcaactactc ttccaacacc aactaccagt acttcgtaat   3300
attgttcaaa tcattgaact tatcaataat cgagctggag aagcggct                3348

<210>   1730
<211>   1116
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type I restriction-modification system, R subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902836 (0.E+01)

<400>   1730
Met Gly Asn Phe Ser Phe Leu Leu Lys Asn Asp Glu Tyr Glu Ser Phe 
1               5                   10                  15      

Ser Lys Pro Cys Ile Glu Ala Glu Asn Met Ile Ala Thr Ser Thr Val 
            20                  25                  30          

Ala Thr Ala Phe Met Ala Arg Arg Ala Leu Glu Gln Ala Val His Trp 
        35                  40                  45              

Ile Tyr Ser His Asp Ser Tyr Leu Glu Ala Pro Tyr Arg Ala Thr Leu 
    50                  55                  60                  

Ser Ser Leu Val Trp Asp Asp Asp Phe Arg Asp Ile Val Asp Ser Glu 
65                  70                  75                  80  

Leu His Lys Gln Ile Val Leu Leu Ile Arg Trp Gly Asn His Ala Ala 
                85                  90                  95      

His Gly Gly Glu Ile Lys Glu Arg Glu Ala Ile Leu Ala Leu His His 
            100                 105                 110         

Leu Tyr Gln Phe Val Asn Phe Ile Asp Tyr Cys Tyr Ser Asn Glu Phe 
        115                 120                 125             

Val Glu Arg Tyr Phe Asp Glu Lys Cys Leu Pro Leu Ser Ala Asn Ile 
    130                 135                 140                 

Lys Tyr Arg Glu Thr Pro Gln Ser Met Ile Lys Leu Gln Asp Ser Leu 
145                 150                 155                 160 

Pro Glu Leu Pro Asp Phe His Glu Gln Met Ala Ala Gln Ser Val Glu 
                165                 170                 175     

Val Gln Glu Thr Tyr Thr Glu Lys Arg Glu Thr Ala Ala Gln Arg Gln 
            180                 185                 190         

Asp Val Pro Phe His Ile Asp Gln Leu Ser Glu Ala Glu Thr Arg Lys 
        195                 200                 205             

Leu Phe Ile Asp Ile Asp Leu Arg Leu Ala Gly Trp Ile Phe Glu Glu 
    210                 215                 220                 

Asn Cys Arg Val Glu Ile Ala Val Asp Gly Leu Lys His Gly Ser Gly 
225                 230                 235                 240 

Ile Gly Tyr Cys Asp Tyr Val Leu Tyr Gly Lys Asn Gly Lys Ile Leu 
                245                 250                 255     

Ala Ile Val Glu Ala Lys Lys Ala Ser Val Asn Pro Glu Val Gly Glu 
            260                 265                 270         

Val Gln Val Lys Glu Tyr Ala Glu Ala Leu Glu Lys His Ile Gly Tyr 
        275                 280                 285             

Gln Pro Ile Cys Phe Ile Thr Asn Gly Leu Lys His Tyr Ile Leu Asp 
    290                 295                 300                 

Gly Pro Asn Arg Arg Gln Ile Ala Gly Phe Tyr Ser Gln Glu Glu Leu 
305                 310                 315                 320 

Gln Leu Val Met Asp Arg Arg His Leu Gln Lys Pro Leu Glu Asp Ile 
                325                 330                 335     

Ser Ser Lys Ile Arg Asp Asp Ile Ser Gly Arg His Tyr Gln Lys His 
            340                 345                 350         

Ala Ile Ala Ser Val Cys Glu Ala Phe Ser Asp His Arg Arg Gln Ala 
        355                 360                 365             

Leu Leu Val Met Ala Thr Gly Ala Gly Lys Thr Arg Thr Ala Val Ser 
    370                 375                 380                 

Leu Val Asp Ile Leu Ser Arg His Asn Trp Val Lys Asn Val Leu Phe 
385                 390                 395                 400 

Leu Ala Asp Arg Thr Ser Leu Val Lys Gln Ala Tyr Asp Ser Phe Arg 
                405                 410                 415     

Lys Leu Leu Pro Asp Leu Ser Val Cys Asn Phe Leu Glu Asp Lys Glu 
            420                 425                 430         

Gly Ala Gln Ser Ser Arg Met Val Phe Ser Thr Tyr Pro Thr Met Ile 
        435                 440                 445             

Gly Ala Ile Ser Gly Gln Glu Glu Val Asn Gln Arg Pro Phe Thr Val 
    450                 455                 460                 

Gly His Phe Asp Leu Ile Ile Ile Asp Glu Ser His Arg Ser Ile Tyr 
465                 470                 475                 480 

Gln Lys Tyr Lys Ser Ile Phe Asp Tyr Phe Asp Ala Arg Ile Val Gly 
                485                 490                 495     

Leu Thr Ala Thr Pro Arg Gln Asp Leu Asp Lys Asn Thr Tyr Gly Phe 
            500                 505                 510         

Phe Asn Leu Glu Asn Gly Val Pro Thr Tyr Ala Tyr Asp Leu Glu Glu 
        515                 520                 525             

Ala Val Lys Asp Gly Tyr Leu Val Ala Tyr His Ser Ile Glu Thr Lys 
    530                 535                 540                 

Leu Lys Leu Pro Thr Asp Gly Leu His Tyr Asp Asp Leu Ser Glu Glu 
545                 550                 555                 560 

Glu Lys Glu His Phe Asp Ser Lys Phe Glu Asp Asn Ser Cys Glu Lys 
                565                 570                 575     

Asp Ile Asp Gly Ser Val Phe Asn Ser Phe Ile Phe Asn Lys Ser Thr 
            580                 585                 590         

Val Glu Ile Val Leu Asn Glu Leu Met Thr Arg Gly Ile Gln Thr Ala 
        595                 600                 605             

Ser Gly Asp Glu Ile Gly Lys Thr Ile Ile Phe Ala Lys Asn His Asp 
    610                 615                 620                 

His Ala Glu Tyr Ile Arg Gly Ile Phe Asn Asn Arg Tyr Pro Glu Lys 
625                 630                 635                 640 

Gly Ser Asp Tyr Ala Gln Val Ile Asp Tyr Ser Ile Lys His Tyr Gln 
                645                 650                 655     

Thr Leu Ile Asp Asp Phe Lys Ile Lys Glu Lys Tyr Pro Gln Ile Ala 
            660                 665                 670         

Ile Ser Val Asp Met Leu Asp Thr Gly Ile Asp Val Pro Glu Val Val 
        675                 680                 685             

Asn Leu Val Phe Phe Lys Lys Val Arg Ser Lys Thr Lys Phe Trp Gln 
    690                 695                 700                 

Met Ile Gly Arg Gly Thr Arg Leu Cys Lys Asp Leu Phe Gly Pro Glu 
705                 710                 715                 720 

Gln Asp Lys Glu Asn Phe Leu Val Phe Asp Tyr Gly Asp Asn Phe Asp 
                725                 730                 735     

Tyr Phe Arg Ala Asp Pro Arg Asp Gly Glu Gly Arg His Ile Val Ser 
            740                 745                 750         

Leu Thr Gln Arg Leu Phe Asn Ile Lys Val Asp Leu Ile Arg Glu Leu 
        755                 760                 765             

Gln Gly Leu Gln Tyr Gln Glu Asp Gln Phe Ala Arg Ala Tyr Arg Gln 
    770                 775                 780                 

Gln Leu Val Ser Glu Leu Gln Gly Arg Ile Glu Ser Leu Asn Glu Leu 
785                 790                 795                 800 

Asp Phe Arg Val Arg Met Val Leu Asp Thr Val Tyr Ser Tyr Arg Lys 
                805                 810                 815     

Leu Glu Ser Trp Gln Asn Leu Thr Ala Val Thr Ser Glu Thr Ile Gln 
            820                 825                 830         

Lys Asn Leu Ser Pro Leu Leu Phe Asp Glu Asp Lys Glu Asp Glu Met 
        835                 840                 845             

Ala Arg Arg Phe Asp Leu Trp Leu Leu His Ile Gln Leu Gly Gln Leu 
    850                 855                 860                 

Thr Ala Lys Ser Ser Thr Val His Ile Ser Gln Val Met Lys Thr Ala 
865                 870                 875                 880 

Arg Ala Leu Ser Ala Ile Gly Asn Ile Pro Gln Val Phe Glu Gln Ala 
                885                 890                 895     

Glu Ile Ile Arg Lys Val Gln Glu Pro Glu Phe Trp Lys Glu Val Asn 
            900                 905                 910         

Leu Ser Asp Leu Glu Lys Ile Arg Leu Ala Ile Arg Asp Leu Leu Gln 
        915                 920                 925             

Phe Leu Asp Lys Thr Asp Arg Lys Pro Tyr Tyr Val Asn Phe Glu Asp 
    930                 935                 940                 

Arg Ile Leu Ser Thr Val His Glu Thr Thr Ala Phe Leu Gln Val Asn 
945                 950                 955                 960 

Asp Leu Arg Ser Tyr Asn Glu Lys Val Glu His Tyr Leu Lys Thr His 
                965                 970                 975     

Leu Asp Glu Glu Ser Ile Ser Lys Leu Tyr His Asn Lys Lys Leu Thr 
            980                 985                 990         

Ser Asp Asp Met Leu Ala Leu Glu Lys Leu Leu Trp Glu Lys Leu Gly 
        995                 1000                1005            

Ser Lys Ala Asp Tyr Gln Ser His Tyr Glu Asn Lys Ala Ile Pro Arg 
    1010                1015                1020                

Leu Val Arg Glu Ile Ile Gly Leu Asp Arg Glu Ser Ala Asn Arg Ile 
1025                1030                1035                1040

Phe Ser Lys Phe Leu Ser Asp Glu Asn Leu Asn Ala Arg Gln Ile Ser 
                1045                1050                1055    

Phe Val Lys Leu Ile Val Asp Tyr Ile Val Glu Asn Gly Phe Leu Glu 
            1060                1065                1070        

Thr Lys Val Leu Thr Gln Glu Pro Phe Lys Ser Tyr Gly Ser Val Gln 
        1075                1080                1085            

Leu Leu Phe Gln His Gln Leu Pro Val Leu Arg Asn Ile Val Gln Ile 
    1090                1095                1100                

Ile Glu Leu Ile Asn Asn Arg Ala Gly Glu Ala Ala 
1105                1110                1115    

<210>   1731
<211>   468
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1731
atgaataaat cagaacaccg ccaccaactt atacgcgctc ttatcacaaa aaacaagatt   60
catacacagg ctgagttgca agcccttctt gctgagaacg acattcaagt aacccaggca   120
accctctcac gcgacatcaa aaatatgaac ctatcaaaag tccgcgaaga agatagcgct   180
tattatgttc ttaacaatgg ttccatctca aaatgggaaa aacgtctcga actctacatg   240
gaagacgccc ttgtctggat gcgcccagtt caacaccaag tcctactaaa aacccttcct   300
ggactggctc aatcctttgg ttctatcatt gatactttga gcttccctga cgctatcgct   360
accctttgtg gtaatgatgt ctgtcttatc atctgtgaag atgcagatac tgctcaaaag   420
tgctttgaag aactgaaaaa attcgcccca ccatttttct ttgaagaa                468

<210>   1732
<211>   156
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional repressor, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902837 (3.E-87)

<400>   1732
Met Asn Lys Ser Glu His Arg His Gln Leu Ile Arg Ala Leu Ile Thr 
1               5                   10                  15      

Lys Asn Lys Ile His Thr Gln Ala Glu Leu Gln Ala Leu Leu Ala Glu 
            20                  25                  30          

Asn Asp Ile Gln Val Thr Gln Ala Thr Leu Ser Arg Asp Ile Lys Asn 
        35                  40                  45              

Met Asn Leu Ser Lys Val Arg Glu Glu Asp Ser Ala Tyr Tyr Val Leu 
    50                  55                  60                  

Asn Asn Gly Ser Ile Ser Lys Trp Glu Lys Arg Leu Glu Leu Tyr Met 
65                  70                  75                  80  

Glu Asp Ala Leu Val Trp Met Arg Pro Val Gln His Gln Val Leu Leu 
                85                  90                  95      

Lys Thr Leu Pro Gly Leu Ala Gln Ser Phe Gly Ser Ile Ile Asp Thr 
            100                 105                 110         

Leu Ser Phe Pro Asp Ala Ile Ala Thr Leu Cys Gly Asn Asp Val Cys 
        115                 120                 125             

Leu Ile Ile Cys Glu Asp Ala Asp Thr Ala Gln Lys Cys Phe Glu Glu 
    130                 135                 140                 

Leu Lys Lys Phe Ala Pro Pro Phe Phe Phe Glu Glu 
145                 150                 155     

<210>   1733
<211>   2271
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1733
atgcgtttta atcaatatag ttatatcaat tttccaaaag aaaatgtctt atctgaacta   60
aaaaaatgtg gctttgattt acaaaataca gccaatcaca aagactcact tgaaaccttt   120
ttacgtcgtt tctttttcac ttatcaagac accaactacc cactttctat cctagcagct   180
gataaaaaaa cagacctgct gacatttttt caatcagaag atgaactgac agcagatatt   240
ttttatactg ttgcttttca acttttaggc ttttcttatt tggttgactt cgaagatagt   300
gacgtttttc gtaaagaaac tggatttccc attatatatg gtgacttgat tgaaaatctc   360
tatcagttac tcaatactcg caccaaaaaa ggaaatactc ttatcgacca acttgttagt   420
gatggtctta ttccggagga taatgactac cactacttta acggcaagag tttggctact   480
ttttctaacc aggatgtcat tcgtgaagtc gtttacgttg agtctcgtgt cgatactgac   540
caaaaagggc tatcagacct agtaaaggtt agcattattc gccctcgttt tgatggaaaa   600
atccctgcca tcatgacagc cagcccttat catcagggaa ccaatgacaa ggctagtgac   660
aaggctctct acaagatgga gggcgagctt gaggttaagc ttcctcacaa gattgagcta   720
gagaaacctc aactaaatct cgtccaaccc caaggtaaag ctgagcttat agcagaggct   780
gaggaaaagc taactcacat caactctagc tatacactaa acgactactt ccttccgaga   840
ggctttgcca atctctatgt ctcaggtgtt ggtaccaaag actcgacagg tttcatgact   900
aatggagact accagcaaat cgaggcttat aaaaatgtca tcgattggct taacggtcgt   960
tgccgtgcct ttactgatca cacgcgccag cgtcaagtca aggctgattg gtcaaacgga   1020
aaagttgcta caacaggact ttcctatcta ggtaccatgt ccaatggtct tgcgactaca   1080
ggagtcgatg gtttagaagt tatcattgcc gaggcaggaa tttcatcatg gtacaactac   1140
taccgtgaaa acggtctggt gactagccca ggtggttatc caggtgagga ctttgactcc   1200
cttgctgagt taacctattc tcgtaatctc ttagctggcg actatatccg tggcaatgaa   1260
gctcaccaag ctgacttaga aaaagtgaaa gctcagctag accgaaaaac tggggactac   1320
aatcagtttt ggcatgaccg caattatctg ctcaatgccc ataaagtaaa ggcagaggtt   1380
gtctttactc atggttctca ggattggaat gtcaaaccac ttcatgttta ccagatgttc   1440
catgctcttc ctactcatat acacaagcat ctctttttcc ataatggtgc ccatgtttac   1500
atgaacaatt ggcaatcaat tgacttccgt gagtccataa atgccttatt gaccaagaaa   1560
ttactaggac aggaaacaga ctttcaactt cctactgtta tctggcagga caatacagct   1620
ccacagactt ggttatcact tgataacttc ggtgggcaag aaaactgtga aaccttctca   1680
cttggtcaag aagagcaagc tattcaaaac cagtacccag ataaggattt tgagcgctat   1740
ggtaagacat accaaacctt caatacagag ctctatcaag ggaaagccaa tcagattact   1800
attaaccttc ctgtgactaa agatctccac ctaaacggtc gcgctcagct caatcttcgt   1860
atcaaatcca gtacaaacaa ggggctctta tctgcccaac tgctagaatt tgggcaaaag   1920
aaatacctac aaccttatcc agctatttta agtgctagaa ccattgacaa cggtcgctat   1980
cacatgttgg aaaatctctg tgaattgcca tttagaccag aggcacaacg agtcgtgaca   2040
aaaggttacc ttaatttaca aaatagaaat gatttactgt tagtagagga tattactgca   2100
gatgaatgga tggacgttca atttgaactg cagccaacta tttacaagct aaaagaagga   2160
gacactctcc gtttagtcct ctatactact gactttgaaa tcaccatccg tgacaataca   2220
gactaccact tgactgtcga cctcgctcag tccatgctta ccttaccttg c            2271

<210>   1734
<211>   757
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   X-pro dipeptidyl-peptidase (pepX)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902838 (0.E+01)

<400>   1734
Met Arg Phe Asn Gln Tyr Ser Tyr Ile Asn Phe Pro Lys Glu Asn Val 
1               5                   10                  15      

Leu Ser Glu Leu Lys Lys Cys Gly Phe Asp Leu Gln Asn Thr Ala Asn 
            20                  25                  30          

His Lys Asp Ser Leu Glu Thr Phe Leu Arg Arg Phe Phe Phe Thr Tyr 
        35                  40                  45              

Gln Asp Thr Asn Tyr Pro Leu Ser Ile Leu Ala Ala Asp Lys Lys Thr 
    50                  55                  60                  

Asp Leu Leu Thr Phe Phe Gln Ser Glu Asp Glu Leu Thr Ala Asp Ile 
65                  70                  75                  80  


Phe Tyr Thr Val Ala Phe Gln Leu Leu Gly Phe Ser Tyr Leu Val Asp 
                85                  90                  95      

Phe Glu Asp Ser Asp Val Phe Arg Lys Glu Thr Gly Phe Pro Ile Ile 
            100                 105                 110         

Tyr Gly Asp Leu Ile Glu Asn Leu Tyr Gln Leu Leu Asn Thr Arg Thr 
        115                 120                 125             

Lys Lys Gly Asn Thr Leu Ile Asp Gln Leu Val Ser Asp Gly Leu Ile 
    130                 135                 140                 

Pro Glu Asp Asn Asp Tyr His Tyr Phe Asn Gly Lys Ser Leu Ala Thr 
145                 150                 155                 160 

Phe Ser Asn Gln Asp Val Ile Arg Glu Val Val Tyr Val Glu Ser Arg 
                165                 170                 175     

Val Asp Thr Asp Gln Lys Gly Leu Ser Asp Leu Val Lys Val Ser Ile 
            180                 185                 190         

Ile Arg Pro Arg Phe Asp Gly Lys Ile Pro Ala Ile Met Thr Ala Ser 
        195                 200                 205             

Pro Tyr His Gln Gly Thr Asn Asp Lys Ala Ser Asp Lys Ala Leu Tyr 
    210                 215                 220                 

Lys Met Glu Gly Glu Leu Glu Val Lys Leu Pro His Lys Ile Glu Leu 
225                 230                 235                 240 

Glu Lys Pro Gln Leu Asn Leu Val Gln Pro Gln Gly Lys Ala Glu Leu 
                245                 250                 255     

Ile Ala Glu Ala Glu Glu Lys Leu Thr His Ile Asn Ser Ser Tyr Thr 
            260                 265                 270         

Leu Asn Asp Tyr Phe Leu Pro Arg Gly Phe Ala Asn Leu Tyr Val Ser 
        275                 280                 285             

Gly Val Gly Thr Lys Asp Ser Thr Gly Phe Met Thr Asn Gly Asp Tyr 
    290                 295                 300                 

Gln Gln Ile Glu Ala Tyr Lys Asn Val Ile Asp Trp Leu Asn Gly Arg 
305                 310                 315                 320 

Cys Arg Ala Phe Thr Asp His Thr Arg Gln Arg Gln Val Lys Ala Asp 
                325                 330                 335     

Trp Ser Asn Gly Lys Val Ala Thr Thr Gly Leu Ser Tyr Leu Gly Thr 
            340                 345                 350         

Met Ser Asn Gly Leu Ala Thr Thr Gly Val Asp Gly Leu Glu Val Ile 
        355                 360                 365             

Ile Ala Glu Ala Gly Ile Ser Ser Trp Tyr Asn Tyr Tyr Arg Glu Asn 
    370                 375                 380                 

Gly Leu Val Thr Ser Pro Gly Gly Tyr Pro Gly Glu Asp Phe Asp Ser 
385                 390                 395                 400 

Leu Ala Glu Leu Thr Tyr Ser Arg Asn Leu Leu Ala Gly Asp Tyr Ile 
                405                 410                 415     


Arg Gly Asn Glu Ala His Gln Ala Asp Leu Glu Lys Val Lys Ala Gln 
            420                 425                 430         

Leu Asp Arg Lys Thr Gly Asp Tyr Asn Gln Phe Trp His Asp Arg Asn 
        435                 440                 445             

Tyr Leu Leu Asn Ala His Lys Val Lys Ala Glu Val Val Phe Thr His 
    450                 455                 460                 

Gly Ser Gln Asp Trp Asn Val Lys Pro Leu His Val Tyr Gln Met Phe 
465                 470                 475                 480 

His Ala Leu Pro Thr His Ile His Lys His Leu Phe Phe His Asn Gly 
                485                 490                 495     

Ala His Val Tyr Met Asn Asn Trp Gln Ser Ile Asp Phe Arg Glu Ser 
            500                 505                 510         

Ile Asn Ala Leu Leu Thr Lys Lys Leu Leu Gly Gln Glu Thr Asp Phe 
        515                 520                 525             

Gln Leu Pro Thr Val Ile Trp Gln Asp Asn Thr Ala Pro Gln Thr Trp 
    530                 535                 540                 

Leu Ser Leu Asp Asn Phe Gly Gly Gln Glu Asn Cys Glu Thr Phe Ser 
545                 550                 555                 560 

Leu Gly Gln Glu Glu Gln Ala Ile Gln Asn Gln Tyr Pro Asp Lys Asp 
                565                 570                 575     

Phe Glu Arg Tyr Gly Lys Thr Tyr Gln Thr Phe Asn Thr Glu Leu Tyr 
            580                 585                 590         

Gln Gly Lys Ala Asn Gln Ile Thr Ile Asn Leu Pro Val Thr Lys Asp 
        595                 600                 605             

Leu His Leu Asn Gly Arg Ala Gln Leu Asn Leu Arg Ile Lys Ser Ser 
    610                 615                 620                 

Thr Asn Lys Gly Leu Leu Ser Ala Gln Leu Leu Glu Phe Gly Gln Lys 
625                 630                 635                 640 

Lys Tyr Leu Gln Pro Tyr Pro Ala Ile Leu Ser Ala Arg Thr Ile Asp 
                645                 650                 655     

Asn Gly Arg Tyr His Met Leu Glu Asn Leu Cys Glu Leu Pro Phe Arg 
            660                 665                 670         

Pro Glu Ala Gln Arg Val Val Thr Lys Gly Tyr Leu Asn Leu Gln Asn 
        675                 680                 685             

Arg Asn Asp Leu Leu Leu Val Glu Asp Ile Thr Ala Asp Glu Trp Met 
    690                 695                 700                 

Asp Val Gln Phe Glu Leu Gln Pro Thr Ile Tyr Lys Leu Lys Glu Gly 
705                 710                 715                 720 

Asp Thr Leu Arg Leu Val Leu Tyr Thr Thr Asp Phe Glu Ile Thr Ile 
                725                 730                 735     

Arg Asp Asn Thr Asp Tyr His Leu Thr Val Asp Leu Ala Gln Ser Met 
            740                 745                 750         

Leu Thr Leu Pro Cys 
        755         

<210>   1735
<211>   3126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1735
gtgagaagga tagaggagaa gtgtaaattg atcgcacaac tagatacaaa aacagtctat   60
agttttatgg aaagcgtcat ttcgatcgaa aagtatgtga gagcagctaa agaatacggc   120
tacactcatt tggctatgat ggatattgac aatctttatg gcgctttcga ctttctagag   180
attacaaaaa aatacggcat tcatcctttg ctagggcttg aaatgacagt gtttgtagat   240
gatcagggag tgaatttgcg ctttttagct ctatctagtg tgggctatca gcagttgatg   300
aagctttcga cagccaagat gcagggggag aaaacttggt cagtcctgtc ccagtacctg   360
gaggatatcg cggtcattgt gccttatttt gatagagttg agtcgttaga actaggctgt   420
gattactata taggggttta tccagaaaca ctagcaagcg aatttcatca tcctatctta   480
cctctttatc gggtcaacgc ttttgaaagc agggatagag aagttcttca agttttaaca   540
gcgattaaag aaaatctacc gctcagagaa gttcccttgc gttcgagaca agatgtcttt   600
atatcagcaa gttctttaga gaaactattc caagagcgtt ttccgcaagc tttggacaat   660
ttagaaaagc ttatttcagg catttcttac gacttggata ctagtctgaa actgcctcgt   720
tttaatccag ctagaccagc agtagaggag ttgagagagc gtgctgaact ggggcttgtt   780
cagaaggggt tgactagtaa agaatatcaa gatagactag accaagaatt gtctgttatt   840
catgatatgg gctttgatga ttatttcttg gttgtttggg atttgttgcg ttttggacaa   900
tcgaatggct attatatggg aatgggaagg ggttctgcag taggcagttt ggtttcttat   960
gccttagaca tcacggggat tgacccagta gagaaaaatc tgatttttga acgctttctt   1020
aatcgtgaac gctataccat gcctgatatt gatattgata tcccagatat ttatcgtcca   1080
gattttatca gatatgttgg taataaatat ggtagtaaac atgcggcaca aatcgttact   1140
ttttcaacct ttggagccaa gcaagctctt cgagatgtct tgaaacgctt tggtgtgcca   1200
gagtatgaat tatctgcaat tactaagaaa atcagttttc gtgacaatct taagtcggcc   1260
tatgagggaa atctccagtt tcgtcagcaa atcaatagta agttagaata ccaaaaagct   1320
tttgagattg cttgcaagat agagggctat ccaaggcaaa cctctgtcca tgcggctggt   1380
gttgtaatta gtgaccaaga tttaaccaac tacattcctc taaagtatgg tgatgaaatt   1440
ccactgactc agtatgatgc tcatggagtt gaggctagcg gacttttgaa gatggacttt   1500
ctgggactac gaaatttgac ctttgtccag aagatgcaag agttgcttgc tgaaacagaa   1560
ggtattcatc tgaaaattga agaaatcgat ttagaagaca aagaaacgtt agctttattt   1620
gcctctggta atacaaaagg tatctttcaa tttgagcaac caggtgccat tcgtctgctt   1680
aagcgtgtgc aaccagtctg ttttgaagat gtcgtcgcga ctacttctct aaatcgaccg   1740
ggtgctagtg actatatcaa taattttgtg gcaagaaagc atgggcagga agaagtgact   1800
gttctggatc cagtactgga ggatattttg gctccaacct acggcataat gctctatcag   1860
gagcaggtta tgcaggttgc ccagcgactt gccggattta gtcttgggaa agccgatatt   1920
ttgcgtcggg ctatggggaa aaaggatgcc tctgccatgc atgagatgag ggcttccttt   1980

attcaaggtt cattagaagc tggtcatact gtggaaaaag cagagcaggt ctttgatgtt   2040
atggagaagt ttgcaggtta tggttttaac aggtcacacg cctatgccta ctcagccttg   2100
gccttccagt tggcttattt caaaacgcat tatccagcca ttttttatca ggtcatgtta   2160
aattcttcca acagtgatta cttaatagat gcacttgaag caggttttga agtagcctct   2220
ctatccatca acaccattcc ctatcacgat aaaattgcca acaaggccat ctatctaggt   2280
ttgaaatcca ttaaaggagt cagtaatgat ttagctctct ggattattga aaatagacct   2340
tattctaaca ttgaagattt tatagctaaa ttacctgaga attatctgaa acttcctctg   2400
ctagaacctt tggtaaaagt tggtcttttc gattcatttg aaaaaaatcg tcaaaaagta   2460
tttaataact tagctaatct atttgaattt gtgaaagagt tgggaagttt gtttggagat   2520
gctatttata gttggcagga atcggaagat tggacggaac aagaaaaatt ttatatggaa   2580
caagagcttt tagggatagg tgtcagcaaa catccactac aagctattgc aagtaaggct   2640
atttacccga ttaccccaat cggaaatttg tcagaaaata gctatgctat tatcttggtt   2700
gaagttcaga aaataaaagt gattcgtacc aaaaagggtg aaaatatggc cttcttacag   2760
gcagatgata gtaagaaaaa attggatgtc actctctttt cagacttata tcgtcaggtt   2820
ggacaggaaa taaaagaggg agccttctac tatgtaaaag gaaaaataca atcacgtgat   2880
ggccgtctgc aaatgattgc acaagaaata agagaagcag ttgctgaacg cttttggata   2940
caggtgaaaa atcatgaatc ggatcaagaa atttcacgca ttttagaaca atttaaaggc   3000
ccaatcccag tcatcatccg gtatgaagag gaacagaaaa ccatcgtttc tccccatcat   3060
tttgtagcta aatccaatga attagaggag aaattgaatg aaatcgttat gaaaacgatt   3120
tatcgc                                                              3126

<210>   1736
<211>   1042
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA polymerase III, alpha subunit (dnaE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902839 (0.E+01)

<400>   1736
Met Arg Arg Ile Glu Glu Lys Cys Lys Leu Ile Ala Gln Leu Asp Thr 
1               5                   10                  15      

Lys Thr Val Tyr Ser Phe Met Glu Ser Val Ile Ser Ile Glu Lys Tyr 
            20                  25                  30          

Val Arg Ala Ala Lys Glu Tyr Gly Tyr Thr His Leu Ala Met Met Asp 
        35                  40                  45              

Ile Asp Asn Leu Tyr Gly Ala Phe Asp Phe Leu Glu Ile Thr Lys Lys 
    50                  55                  60                  

Tyr Gly Ile His Pro Leu Leu Gly Leu Glu Met Thr Val Phe Val Asp 
65                  70                  75                  80  

Asp Gln Gly Val Asn Leu Arg Phe Leu Ala Leu Ser Ser Val Gly Tyr 
                85                  90                  95      

Gln Gln Leu Met Lys Leu Ser Thr Ala Lys Met Gln Gly Glu Lys Thr 
            100                 105                 110         

Trp Ser Val Leu Ser Gln Tyr Leu Glu Asp Ile Ala Val Ile Val Pro 
        115                 120                 125             

Tyr Phe Asp Arg Val Glu Ser Leu Glu Leu Gly Cys Asp Tyr Tyr Ile 
    130                 135                 140                 

Gly Val Tyr Pro Glu Thr Leu Ala Ser Glu Phe His His Pro Ile Leu 
145                 150                 155                 160 

Pro Leu Tyr Arg Val Asn Ala Phe Glu Ser Arg Asp Arg Glu Val Leu 
                165                 170                 175     

Gln Val Leu Thr Ala Ile Lys Glu Asn Leu Pro Leu Arg Glu Val Pro 
            180                 185                 190         

Leu Arg Ser Arg Gln Asp Val Phe Ile Ser Ala Ser Ser Leu Glu Lys 
        195                 200                 205             

Leu Phe Gln Glu Arg Phe Pro Gln Ala Leu Asp Asn Leu Glu Lys Leu 
    210                 215                 220                 

Ile Ser Gly Ile Ser Tyr Asp Leu Asp Thr Ser Leu Lys Leu Pro Arg 
225                 230                 235                 240 

Phe Asn Pro Ala Arg Pro Ala Val Glu Glu Leu Arg Glu Arg Ala Glu 
                245                 250                 255     

Leu Gly Leu Val Gln Lys Gly Leu Thr Ser Lys Glu Tyr Gln Asp Arg 
            260                 265                 270         

Leu Asp Gln Glu Leu Ser Val Ile His Asp Met Gly Phe Asp Asp Tyr 
        275                 280                 285             

Phe Leu Val Val Trp Asp Leu Leu Arg Phe Gly Gln Ser Asn Gly Tyr 
    290                 295                 300                 

Tyr Met Gly Met Gly Arg Gly Ser Ala Val Gly Ser Leu Val Ser Tyr 
305                 310                 315                 320 

Ala Leu Asp Ile Thr Gly Ile Asp Pro Val Glu Lys Asn Leu Ile Phe 
                325                 330                 335     

Glu Arg Phe Leu Asn Arg Glu Arg Tyr Thr Met Pro Asp Ile Asp Ile 
            340                 345                 350         

Asp Ile Pro Asp Ile Tyr Arg Pro Asp Phe Ile Arg Tyr Val Gly Asn 
        355                 360                 365             

Lys Tyr Gly Ser Lys His Ala Ala Gln Ile Val Thr Phe Ser Thr Phe 
    370                 375                 380                 

Gly Ala Lys Gln Ala Leu Arg Asp Val Leu Lys Arg Phe Gly Val Pro 
385                 390                 395                 400 

Glu Tyr Glu Leu Ser Ala Ile Thr Lys Lys Ile Ser Phe Arg Asp Asn 
                405                 410                 415     

Leu Lys Ser Ala Tyr Glu Gly Asn Leu Gln Phe Arg Gln Gln Ile Asn 
            420                 425                 430         

Ser Lys Leu Glu Tyr Gln Lys Ala Phe Glu Ile Ala Cys Lys Ile Glu 
        435                 440                 445             

Gly Tyr Pro Arg Gln Thr Ser Val His Ala Ala Gly Val Val Ile Ser 
    450                 455                 460                 

Asp Gln Asp Leu Thr Asn Tyr Ile Pro Leu Lys Tyr Gly Asp Glu Ile 
465                 470                 475                 480 

Pro Leu Thr Gln Tyr Asp Ala His Gly Val Glu Ala Ser Gly Leu Leu 
                485                 490                 495     

Lys Met Asp Phe Leu Gly Leu Arg Asn Leu Thr Phe Val Gln Lys Met 
            500                 505                 510         

Gln Glu Leu Leu Ala Glu Thr Glu Gly Ile His Leu Lys Ile Glu Glu 
        515                 520                 525             

Ile Asp Leu Glu Asp Lys Glu Thr Leu Ala Leu Phe Ala Ser Gly Asn 
    530                 535                 540                 

Thr Lys Gly Ile Phe Gln Phe Glu Gln Pro Gly Ala Ile Arg Leu Leu 
545                 550                 555                 560 

Lys Arg Val Gln Pro Val Cys Phe Glu Asp Val Val Ala Thr Thr Ser 
                565                 570                 575     

Leu Asn Arg Pro Gly Ala Ser Asp Tyr Ile Asn Asn Phe Val Ala Arg 
            580                 585                 590         

Lys His Gly Gln Glu Glu Val Thr Val Leu Asp Pro Val Leu Glu Asp 

        595                 600                 605             

Ile Leu Ala Pro Thr Tyr Gly Ile Met Leu Tyr Gln Glu Gln Val Met 
    610                 615                 620                 

Gln Val Ala Gln Arg Leu Ala Gly Phe Ser Leu Gly Lys Ala Asp Ile 
625                 630                 635                 640 

Leu Arg Arg Ala Met Gly Lys Lys Asp Ala Ser Ala Met His Glu Met 
                645                 650                 655     

Arg Ala Ser Phe Ile Gln Gly Ser Leu Glu Ala Gly His Thr Val Glu 
            660                 665                 670         

Lys Ala Glu Gln Val Phe Asp Val Met Glu Lys Phe Ala Gly Tyr Gly 
        675                 680                 685             

Phe Asn Arg Ser His Ala Tyr Ala Tyr Ser Ala Leu Ala Phe Gln Leu 
    690                 695                 700                 

Ala Tyr Phe Lys Thr His Tyr Pro Ala Ile Phe Tyr Gln Val Met Leu 
705                 710                 715                 720 

Asn Ser Ser Asn Ser Asp Tyr Leu Ile Asp Ala Leu Glu Ala Gly Phe 
                725                 730                 735     

Glu Val Ala Ser Leu Ser Ile Asn Thr Ile Pro Tyr His Asp Lys Ile 
            740                 745                 750         

Ala Asn Lys Ala Ile Tyr Leu Gly Leu Lys Ser Ile Lys Gly Val Ser 
        755                 760                 765             

Asn Asp Leu Ala Leu Trp Ile Ile Glu Asn Arg Pro Tyr Ser Asn Ile 
    770                 775                 780                 

Glu Asp Phe Ile Ala Lys Leu Pro Glu Asn Tyr Leu Lys Leu Pro Leu 
785                 790                 795                 800 

Leu Glu Pro Leu Val Lys Val Gly Leu Phe Asp Ser Phe Glu Lys Asn 
                805                 810                 815     

Arg Gln Lys Val Phe Asn Asn Leu Ala Asn Leu Phe Glu Phe Val Lys 
            820                 825                 830         

Glu Leu Gly Ser Leu Phe Gly Asp Ala Ile Tyr Ser Trp Gln Glu Ser 
        835                 840                 845             

Glu Asp Trp Thr Glu Gln Glu Lys Phe Tyr Met Glu Gln Glu Leu Leu 
    850                 855                 860                 

Gly Ile Gly Val Ser Lys His Pro Leu Gln Ala Ile Ala Ser Lys Ala 
865                 870                 875                 880 

Ile Tyr Pro Ile Thr Pro Ile Gly Asn Leu Ser Glu Asn Ser Tyr Ala 
                885                 890                 895     

Ile Ile Leu Val Glu Val Gln Lys Ile Lys Val Ile Arg Thr Lys Lys 
            900                 905                 910         

Gly Glu Asn Met Ala Phe Leu Gln Ala Asp Asp Ser Lys Lys Lys Leu 
        915                 920                 925             

Asp Val Thr Leu Phe Ser Asp Leu Tyr Arg Gln Val Gly Gln Glu Ile 
    930                 935                 940                 

Lys Glu Gly Ala Phe Tyr Tyr Val Lys Gly Lys Ile Gln Ser Arg Asp 
945                 950                 955                 960 

Gly Arg Leu Gln Met Ile Ala Gln Glu Ile Arg Glu Ala Val Ala Glu 
                965                 970                 975     

Arg Phe Trp Ile Gln Val Lys Asn His Glu Ser Asp Gln Glu Ile Ser 
            980                 985                 990         

Arg Ile Leu Glu Gln Phe Lys Gly Pro Ile Pro Val Ile Ile Arg Tyr 
        995                 1000                1005            

Glu Glu Glu Gln Lys Thr Ile Val Ser Pro His His Phe Val Ala Lys 
    1010                1015                1020                

Ser Asn Glu Leu Glu Glu Lys Leu Asn Glu Ile Val Met Lys Thr Ile 
1025                1030                1035                1040

Tyr Arg 
        

<210>   1737
<211>   1005
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1737
atgaaacgta ttgctgtttt gactagtggt ggagacgccc ctggtatgaa cgctgccatc   60
cgtgcagttg ttcgtcaagc aatttcagaa ggaatggaag tttttggtat ctatgacgga   120
tatgctggta tggttgccgg tgaaattcat cccctagatg cagcttcagt aggggacatc   180
atttctcgtg gtggtacttt ccttcactca gctcgttacc cagagttcgc tcaacttgaa   240
gggcaactta aagggattga gcaattgaaa aaacacggaa ttgaaggtgt agttgttatc   300
ggtggtgacg gatcttacca cggcgctatg cgtttgactg aacatggctt cccagctatt   360
ggtcttccag gtacaatcga taacgatatc gttggtactg actttacaat cggttttgac   420
acagcggtta ctactgccat ggacgctatc gataagattc gtgatacatc atcaagtcac   480
cgtcgtactt ttgtaatcga agttatggga cgtaacgctg gtgatatcgc tctttgggct   540
ggtattgcaa ctggtgctga tgaaatcatc atccctgaag caggcttcaa gatggaagat   600
atcgtagcaa gcatcaaagc tggttatgaa tgtggtaaaa aacacaatat tatcgtctta   660
gctgaaggtg tgatgtcagc ggctgaattt ggtcaaaaac ttaaagaagc tggagataca   720
agcgaccttc gtgtaacaga acttggacat attcaacgtg gtggttctcc aactgcgcgt   780
gaccgtgttt tggcgtcacg tatgggtgca catgctgtta aacttcttaa agaaggtatc   840
ggtggtgttg cggttggtat tcgtaacgaa aaaatggttg aaaatccaat tcttggtact   900
gcagaagaag gggcattgtt tagccttact gcagaaggta agattgtggt taacaaccca   960
cacaaagccg atattgagct atctagcttg aataagagct tgtca                   1005

<210>   1738
<211>   335
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   6-phosphofructokinase (pfk)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902840 (0.E+01)

<400>   1738
Met Lys Arg Ile Ala Val Leu Thr Ser Gly Gly Asp Ala Pro Gly Met 
1               5                   10                  15      

Asn Ala Ala Ile Arg Ala Val Val Arg Gln Ala Ile Ser Glu Gly Met 
            20                  25                  30          

Glu Val Phe Gly Ile Tyr Asp Gly Tyr Ala Gly Met Val Ala Gly Glu 
        35                  40                  45              

Ile His Pro Leu Asp Ala Ala Ser Val Gly Asp Ile Ile Ser Arg Gly 
    50                  55                  60                  

Gly Thr Phe Leu His Ser Ala Arg Tyr Pro Glu Phe Ala Gln Leu Glu 
65                  70                  75                  80  

Gly Gln Leu Lys Gly Ile Glu Gln Leu Lys Lys His Gly Ile Glu Gly 
                85                  90                  95      

Val Val Val Ile Gly Gly Asp Gly Ser Tyr His Gly Ala Met Arg Leu 
            100                 105                 110         

Thr Glu His Gly Phe Pro Ala Ile Gly Leu Pro Gly Thr Ile Asp Asn 
        115                 120                 125             

Asp Ile Val Gly Thr Asp Phe Thr Ile Gly Phe Asp Thr Ala Val Thr 
    130                 135                 140                 

Thr Ala Met Asp Ala Ile Asp Lys Ile Arg Asp Thr Ser Ser Ser His 
145                 150                 155                 160 

Arg Arg Thr Phe Val Ile Glu Val Met Gly Arg Asn Ala Gly Asp Ile 
                165                 170                 175     

Ala Leu Trp Ala Gly Ile Ala Thr Gly Ala Asp Glu Ile Ile Ile Pro 
            180                 185                 190         

Glu Ala Gly Phe Lys Met Glu Asp Ile Val Ala Ser Ile Lys Ala Gly 
        195                 200                 205             

Tyr Glu Cys Gly Lys Lys His Asn Ile Ile Val Leu Ala Glu Gly Val 
    210                 215                 220                 

Met Ser Ala Ala Glu Phe Gly Gln Lys Leu Lys Glu Ala Gly Asp Thr 
225                 230                 235                 240 

Ser Asp Leu Arg Val Thr Glu Leu Gly His Ile Gln Arg Gly Gly Ser 
                245                 250                 255     

Pro Thr Ala Arg Asp Arg Val Leu Ala Ser Arg Met Gly Ala His Ala 
            260                 265                 270         

Val Lys Leu Leu Lys Glu Gly Ile Gly Gly Val Ala Val Gly Ile Arg 
        275                 280                 285             

Asn Glu Lys Met Val Glu Asn Pro Ile Leu Gly Thr Ala Glu Glu Gly 
    290                 295                 300                 

Ala Leu Phe Ser Leu Thr Ala Glu Gly Lys Ile Val Val Asn Asn Pro 
305                 310                 315                 320 

His Lys Ala Asp Ile Glu Leu Ser Ser Leu Asn Lys Ser Leu Ser 
                325                 330                 335 

<210>   1739
<211>   1503
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1739
atgaacaaac gtgtaaaaat cgttgcaact ttgggtcctg cggtagaaat ccgtggtggt   60
aaaaaattcg gtgaggacgg atactggggt gaaaaacttg atgttgaagc ttcagctaaa   120
aacattgcta aattgattga agctggtgct aacacattcc gattcaactt ctcacacggc   180
gaccaccaag aacaaggtga gcgtatggca actgttaaac ttgcggaaaa aattgcaggt   240
aaaaaagttg gtttccttct tgatacaaaa ggacctgaaa tccgtacaga attgttcgaa   300
ggtgaagcta aagaatattc atacaaaact ggtgaaaaaa ttcgtgttgc aactaaacaa   360
ggaatcaaat caactcgtga agtgattgcg ttgaacgttg ctggtgctct tgatatctat   420
gatgatgttg aagttggtcg tcaagttttg gttgacgatg gtaaacttgg tcttcgtgtg   480
gttgctaaag atgatgcaac tcgtgaattt gaagttgaag ttgaaaacga tggtatcatc   540
gctaaacaaa aaggtgtgaa catccctaac actaaaattc ctttcccagc tcttgctgaa   600
cgcgataacg acgatatccg tttcggtctt gaacaaggta tcaacttcat cgcaatttca   660
ttcgtacgta ctgcaaaaga tgtgaacgaa gttcgtgcaa tctgtgaaga aactggaaac   720
ggacatgttc aattgttcgc taaaatcgaa aaccaacaag gtatcgataa cttagatgaa   780
atcatcgaag cagctgatgg tattatgatt gctcgtggtg atatgggtat cgaagtaccg   840
ttcgaaatgg ttccagttta tcaaaaaatg attatcaaga aagtcaatgc tgcaggtaaa   900
gttgttatca ctgcaacaaa catgcttgaa acaatgactg aaaaaccacg tgcaactcgt   960
tcagaagtat cagatgtatt caacgctgtt atcgacggaa ctgacgctac aatgttgtca   1020
ggcgagtctg caaacggtaa atacccactc gagtcagtaa ctacaatggc tacaatcgac   1080
aagaacgctc aagctcttct taatgaatac ggacgtcttg attcagattc atttgagcgt   1140
aactctaaga cagaagtaat ggcttctgct gttaaagatg ctactagctc aatggatatc   1200
aaattggttg taactcttac taagacaggt catactgcac gtttgatttc taaataccgt   1260
ccaaatgctg acatcttagc attgacattt gacgaattga cagaacgtgg cttgatgttg   1320
aactggggtg ttatcccaat gttgacagat gctccatctt caactgacga tatgttcgaa   1380
atcgctgaac gtaaagcggt agaagcaggt ctcgttgagt caggcgatga tatcgttatc   1440
gttgctggtg tgccagtagg agaagctgtt cgcacaaaca caatgcgtat ccgcacagta   1500
cgt                                                                 1503


<210>   1740
<211>   501
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyruvate kinase (pyk)
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15902841 (0.E+01)

<400>   1740
Met Asn Lys Arg Val Lys Ile Val Ala Thr Leu Gly Pro Ala Val Glu 
1               5                   10                  15      

Ile Arg Gly Gly Lys Lys Phe Gly Glu Asp Gly Tyr Trp Gly Glu Lys 
            20                  25                  30          

Leu Asp Val Glu Ala Ser Ala Lys Asn Ile Ala Lys Leu Ile Glu Ala 
        35                  40                  45              

Gly Ala Asn Thr Phe Arg Phe Asn Phe Ser His Gly Asp His Gln Glu 
    50                  55                  60                  

Gln Gly Glu Arg Met Ala Thr Val Lys Leu Ala Glu Lys Ile Ala Gly 
65                  70                  75                  80  

Lys Lys Val Gly Phe Leu Leu Asp Thr Lys Gly Pro Glu Ile Arg Thr 
                85                  90                  95      

Glu Leu Phe Glu Gly Glu Ala Lys Glu Tyr Ser Tyr Lys Thr Gly Glu 
            100                 105                 110         

Lys Ile Arg Val Ala Thr Lys Gln Gly Ile Lys Ser Thr Arg Glu Val 
        115                 120                 125             

Ile Ala Leu Asn Val Ala Gly Ala Leu Asp Ile Tyr Asp Asp Val Glu 
    130                 135                 140                 

Val Gly Arg Gln Val Leu Val Asp Asp Gly Lys Leu Gly Leu Arg Val 
145                 150                 155                 160 

Val Ala Lys Asp Asp Ala Thr Arg Glu Phe Glu Val Glu Val Glu Asn 

                165                 170                 175     

Asp Gly Ile Ile Ala Lys Gln Lys Gly Val Asn Ile Pro Asn Thr Lys 
            180                 185                 190         

Ile Pro Phe Pro Ala Leu Ala Glu Arg Asp Asn Asp Asp Ile Arg Phe 
        195                 200                 205             

Gly Leu Glu Gln Gly Ile Asn Phe Ile Ala Ile Ser Phe Val Arg Thr 
    210                 215                 220                 

Ala Lys Asp Val Asn Glu Val Arg Ala Ile Cys Glu Glu Thr Gly Asn 
225                 230                 235                 240 

Gly His Val Gln Leu Phe Ala Lys Ile Glu Asn Gln Gln Gly Ile Asp 
                245                 250                 255     

Asn Leu Asp Glu Ile Ile Glu Ala Ala Asp Gly Ile Met Ile Ala Arg 
            260                 265                 270         

Gly Asp Met Gly Ile Glu Val Pro Phe Glu Met Val Pro Val Tyr Gln 
        275                 280                 285             

Lys Met Ile Ile Lys Lys Val Asn Ala Ala Gly Lys Val Val Ile Thr 
    290                 295                 300                 

Ala Thr Asn Met Leu Glu Thr Met Thr Glu Lys Pro Arg Ala Thr Arg 
305                 310                 315                 320 

Ser Glu Val Ser Asp Val Phe Asn Ala Val Ile Asp Gly Thr Asp Ala 
                325                 330                 335     

Thr Met Leu Ser Gly Glu Ser Ala Asn Gly Lys Tyr Pro Leu Glu Ser 
            340                 345                 350         

Val Thr Thr Met Ala Thr Ile Asp Lys Asn Ala Gln Ala Leu Leu Asn 
        355                 360                 365             

Glu Tyr Gly Arg Leu Asp Ser Asp Ser Phe Glu Arg Asn Ser Lys Thr 
    370                 375                 380                 

Glu Val Met Ala Ser Ala Val Lys Asp Ala Thr Ser Ser Met Asp Ile 
385                 390                 395                 400 

Lys Leu Val Val Thr Leu Thr Lys Thr Gly His Thr Ala Arg Leu Ile 
                405                 410                 415     

Ser Lys Tyr Arg Pro Asn Ala Asp Ile Leu Ala Leu Thr Phe Asp Glu 
            420                 425                 430         

Leu Thr Glu Arg Gly Leu Met Leu Asn Trp Gly Val Ile Pro Met Leu 
        435                 440                 445             

Thr Asp Ala Pro Ser Ser Thr Asp Asp Met Phe Glu Ile Ala Glu Arg 
    450                 455                 460                 

Lys Ala Val Glu Ala Gly Leu Val Glu Ser Gly Asp Asp Ile Val Ile 
465                 470                 475                 480 

Val Ala Gly Val Pro Val Gly Glu Ala Val Arg Thr Asn Thr Met Arg 
                485                 490                 495     

Ile Arg Thr Val Arg 
            500     

<210>   1741
<211>   177
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1741
ttgatactct tcgaaaatct cttcaaacca cgtcagcgtc gccttaccgt atatatgtta   60
ctgacttcgt cagttctatc tacaacctca aagcagtgct ttgagcaacc tgcggctagc   120
ttcctagttt gctctttgat tttcattgag tatgaaataa gatatgcaca aattgat      177

<210>   1742
<211>   59
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1742
Met Ile Leu Phe Glu Asn Leu Phe Lys Pro Arg Gln Arg Arg Leu Thr 
1               5                   10                  15      

Val Tyr Met Leu Leu Thr Ser Ser Val Leu Ser Thr Thr Ser Lys Gln 
            20                  25                  30          

Cys Phe Glu Gln Pro Ala Ala Ser Phe Leu Val Cys Ser Leu Ile Phe 
        35                  40                  45              

Ile Glu Tyr Glu Ile Arg Tyr Ala Gln Ile Asp 
    50                  55                  

<210>   1743
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1743
ttgggtacta agataggtat aagtaaaaac accattagaa attatgaaaa aagggttagg   60
tctactaaga aaaatactat atttgactta gttaaagtat tcagtagctt gatcgatgcc   120
ctctttcctc cagttcaaaa ggattctcct agcgatatcc aatctatcta cgaccaacgg   180
gaaccaccca gacaaggtaa agttctgacc tatgccgaga ggcaactgta tgatcagaaa   240
aacgaagtat cg                                                       252

<210>   1744
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional repressor, degenerate

<400>   1744
Met Gly Thr Lys Ile Gly Ile Ser Lys Asn Thr Ile Arg Asn Tyr Glu 
1               5                   10                  15      

Lys Arg Val Arg Ser Thr Lys Lys Asn Thr Ile Phe Asp Leu Val Lys 
            20                  25                  30          

Val Phe Ser Ser Leu Ile Asp Ala Leu Phe Pro Pro Val Gln Lys Asp 
        35                  40                  45              

Ser Pro Ser Asp Ile Gln Ser Ile Tyr Asp Gln Arg Glu Pro Pro Arg 
    50                  55                  60                  

Gln Gly Lys Val Leu Thr Tyr Ala Glu Arg Gln Leu Tyr Asp Gln Lys 
65                  70                  75                  80  

Asn Glu Val Ser 
                

<210>   1745
<211>   870
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1745
atgaagaaat caagaaaatt agccacatta ggaatctgtt cagccttgtt tttaggcttg   60
gctgcttgtc aacaacaaca tgctacttct gaggggacga atcaaaggca aagcagttca   120
gcgaaagttc catggaaagc ttcatacacc aacctaaaca accaggtaag tacagaagag   180
gtcaaatctc tcttatcagc tcacttggat ccaaatagtg ttgatgcatt ttttaatctc   240
gttaatgact ataataccat tgtcggctca actggcttat caggagattt cacttccttt   300
actcacaccg aatacgatgt tgagaaaatc agtcatctct ggaatcaaaa gaagggcgat   360
tttgttggga ccaactgccg tatcaatagt tattgtcttt tgaaaaattc agtcaccatt   420
ccaaagcttg aaaagaatga ccagttgctt ttcctagata atgatgcgat tgataaagga   480
aaggtctttg attcacaaga taaggaagag tttgatattc tattttcgag agttccaact   540
gagtcaacta cagatgtcaa ggttcacgct gaaaagatgg aagcattctt ctcacaattt   600
caattcaatg aaaaagctcg aatgctgtct gtagtcttgc acgacaattt ggatggcgag   660
tatctgtttg taggccacgt tggggtctta gtacctgctg atgacggttt cttatttgta   720
gagaaattga ctttcgaaga gccctaccaa gcgattaaat ttgctagtaa ggaagattgc   780
tacaagtatt tgggcaccaa gtatgcggat tatacaggcg agggactggc taagcctttt   840
atcatggata atgataagtg ggttaaactt                                    870

<210>   1746
<211>   290
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902843 (e-169)

<400>   1746
Met Lys Lys Ser Arg Lys Leu Ala Thr Leu Gly Ile Cys Ser Ala Leu 
1               5                   10                  15      

Phe Leu Gly Leu Ala Ala Cys Gln Gln Gln His Ala Thr Ser Glu Gly 
            20                  25                  30          

Thr Asn Gln Arg Gln Ser Ser Ser Ala Lys Val Pro Trp Lys Ala Ser 
        35                  40                  45              

Tyr Thr Asn Leu Asn Asn Gln Val Ser Thr Glu Glu Val Lys Ser Leu 
    50                  55                  60                  

Leu Ser Ala His Leu Asp Pro Asn Ser Val Asp Ala Phe Phe Asn Leu 
65                  70                  75                  80  

Val Asn Asp Tyr Asn Thr Ile Val Gly Ser Thr Gly Leu Ser Gly Asp 
                85                  90                  95      

Phe Thr Ser Phe Thr His Thr Glu Tyr Asp Val Glu Lys Ile Ser His 
            100                 105                 110         

Leu Trp Asn Gln Lys Lys Gly Asp Phe Val Gly Thr Asn Cys Arg Ile 
        115                 120                 125             

Asn Ser Tyr Cys Leu Leu Lys Asn Ser Val Thr Ile Pro Lys Leu Glu 
    130                 135                 140                 

Lys Asn Asp Gln Leu Leu Phe Leu Asp Asn Asp Ala Ile Asp Lys Gly 
145                 150                 155                 160 

Lys Val Phe Asp Ser Gln Asp Lys Glu Glu Phe Asp Ile Leu Phe Ser 
                165                 170                 175     

Arg Val Pro Thr Glu Ser Thr Thr Asp Val Lys Val His Ala Glu Lys 
            180                 185                 190         

Met Glu Ala Phe Phe Ser Gln Phe Gln Phe Asn Glu Lys Ala Arg Met 
        195                 200                 205             

Leu Ser Val Val Leu His Asp Asn Leu Asp Gly Glu Tyr Leu Phe Val 
    210                 215                 220                 

Gly His Val Gly Val Leu Val Pro Ala Asp Asp Gly Phe Leu Phe Val 
225                 230                 235                 240 

Glu Lys Leu Thr Phe Glu Glu Pro Tyr Gln Ala Ile Lys Phe Ala Ser 
                245                 250                 255     

Lys Glu Asp Cys Tyr Lys Tyr Leu Gly Thr Lys Tyr Ala Asp Tyr Thr 
            260                 265                 270         

Gly Glu Gly Leu Ala Lys Pro Phe Ile Met Asp Asn Asp Lys Trp Val 
        275                 280                 285             

Lys Leu 
    290 

<210>   1747
<211>   162
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1747
atgacagtaa tcttaggatt tttatttcta tttttgataa gttggtgggt tatttcaatc   60
gttaatagcc agaaaccacg caaaaatgaa acatttattg gctatgtcca aagatacgat   120
attgatggga atggctatca atcattaccg tgtcctcaga ac                      162

<210>   1748
<211>   54
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1748
Met Thr Val Ile Leu Gly Phe Leu Phe Leu Phe Leu Ile Ser Trp Trp 
1               5                   10                  15      

Val Ile Ser Ile Val Asn Ser Gln Lys Pro Arg Lys Asn Glu Thr Phe 
            20                  25                  30          

Ile Gly Tyr Val Gln Arg Tyr Asp Ile Asp Gly Asn Gly Tyr Gln Ser 
        35                  40                  45              

Leu Pro Cys Pro Gln Asn 
    50                  

<210>   1749
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1749
atgaaacatt tattggctat gtccaaagat acgatattga tgggaatggc tatcaatcat   60
taccgtgtcc tcagaactga gaggagttct                                    90

<210>   1750
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein, fusion

<400>   1750
Met Lys His Leu Leu Ala Met Ser Lys Asp Thr Ile Leu Met Gly Met 
1               5                   10                  15      

Ala Ile Asn His Tyr Arg Val Leu Arg Thr Glu Arg Ser Ser 
            20                  25                  30  

<210>   1751
<211>   267
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1751
atgaattatg aagcaagtaa acaactaact gatgcacgat ttaaacgtct tgttggtgtt   60
cagcgcacga cttttgaaga gatattagct gtattaaaaa cagcttatca acttaaacac   120
gcaaaaggtg gacgaaaacc taaattaagc ctagaagacc ttcttatggc cactcttcaa   180
tatgtgcgag aataccgcac ttatgaagaa attgcggctg attttggtat tcacgaaagc   240
aacttaatcc gtcggagcca atgggtt                                       267

<210>   1752
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA, truncation POINT MUTATION
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903122 (7.E-46)

<400>   1752
Met Asn Tyr Glu Ala Ser Lys Gln Leu Thr Asp Ala Arg Phe Lys Arg 
1               5                   10                  15      

Leu Val Gly Val Gln Arg Thr Thr Phe Glu Glu Ile Leu Ala Val Leu 
            20                  25                  30          

Lys Thr Ala Tyr Gln Leu Lys His Ala Lys Gly Gly Arg Lys Pro Lys 
        35                  40                  45              

Leu Ser Leu Glu Asp Leu Leu Met Ala Thr Leu Gln Tyr Val Arg Glu 
    50                  55                  60                  

Tyr Arg Thr Tyr Glu Glu Ile Ala Ala Asp Phe Gly Ile His Glu Ser 
65                  70                  75                  80  

Asn Leu Ile Arg Arg Ser Gln Trp Val 
                85                  

<210>   1753
<211>   309
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1753
atggaattaa aagattttac agaaaaagaa caggaaatga ttaagaaaag gcttacaatg   60
tctaatatta gtgacaaaga aactactgag aagattctgg cgctagtccc acaagacttg   120
attaagcgaa tcccgttttt tgtcagaaaa catgctacaa cacgtacgat taaacgcatt   180
tcaattgaat accctgaact ctacgctgta gctcaaacaa gtggtgagat tccagaaaaa   240
aaacgcgaag aattgcgtca gattatcaca actatctttg aacaaaagat gaataagcat   300
agtattaag                                                           309

<210>   1754
<211>   103
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902846 (2.E-53)

<400>   1754
Met Glu Leu Lys Asp Phe Thr Glu Lys Glu Gln Glu Met Ile Lys Lys 
1               5                   10                  15      

Arg Leu Thr Met Ser Asn Ile Ser Asp Lys Glu Thr Thr Glu Lys Ile 
            20                  25                  30          

Leu Ala Leu Val Pro Gln Asp Leu Ile Lys Arg Ile Pro Phe Phe Val 
        35                  40                  45              

Arg Lys His Ala Thr Thr Arg Thr Ile Lys Arg Ile Ser Ile Glu Tyr 
    50                  55                  60                  

Pro Glu Leu Tyr Ala Val Ala Gln Thr Ser Gly Glu Ile Pro Glu Lys 
65                  70                  75                  80  

Lys Arg Glu Glu Leu Arg Gln Ile Ile Thr Thr Ile Phe Glu Gln Lys 
                85                  90                  95      

Met Asn Lys His Ser Ile Lys 
            100             

<210>   1755
<211>   594
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1755
atgaaaaaat attttattgg cggtttggga agcaatgcct atcatagcaa ggattttctt   60
caagaactag attcgcaggt ctattttcta aatccatatg aaaagcatct tcgagatgaa   120
acagaattga aatcatggtt taaaaatgaa attgtagagg aagaatctat ctgtctgata   180
ggccattctc ttggaggaga tttagctcgt tatttcgcat cggaatttga agaagtaaag   240
aaactgattc ttttggatgg tggctatcta gatttagata agattttacc tttggataca   300
gagttagagg aaactaaaaa ttatatcaaa tctcaaattg tttcggactt agatgttctt   360
acttctaaag aaaaatctga agcaaagcat tggtcagaaa atatggagaa agctgtaaga   420
cagtcttatc actggaatgt tgagtataat agatatgagt tggctataaa ttatgaaaat   480
atagaagcga tactccgcta cggagaaaaa tacaagcttt taagagagaa gtgggagata   540
ccttgtttat tagtcctcgc tatcctaatg aagctacatg gagagaggaa gccc         594

<210>   1756
<211>   198
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902847 (4.E-92)

<400>   1756
Met Lys Lys Tyr Phe Ile Gly Gly Leu Gly Ser Asn Ala Tyr His Ser 
1               5                   10                  15      

Lys Asp Phe Leu Gln Glu Leu Asp Ser Gln Val Tyr Phe Leu Asn Pro 
            20                  25                  30          

Tyr Glu Lys His Leu Arg Asp Glu Thr Glu Leu Lys Ser Trp Phe Lys 
        35                  40                  45              

Asn Glu Ile Val Glu Glu Glu Ser Ile Cys Leu Ile Gly His Ser Leu 
    50                  55                  60                  

Gly Gly Asp Leu Ala Arg Tyr Phe Ala Ser Glu Phe Glu Glu Val Lys 
65                  70                  75                  80  

Lys Leu Ile Leu Leu Asp Gly Gly Tyr Leu Asp Leu Asp Lys Ile Leu 
                85                  90                  95      

Pro Leu Asp Thr Glu Leu Glu Glu Thr Lys Asn Tyr Ile Lys Ser Gln 
            100                 105                 110         

Ile Val Ser Asp Leu Asp Val Leu Thr Ser Lys Glu Lys Ser Glu Ala 
        115                 120                 125             

Lys His Trp Ser Glu Asn Met Glu Lys Ala Val Arg Gln Ser Tyr His 
    130                 135                 140                 

Trp Asn Val Glu Tyr Asn Arg Tyr Glu Leu Ala Ile Asn Tyr Glu Asn 
145                 150                 155                 160 

Ile Glu Ala Ile Leu Arg Tyr Gly Glu Lys Tyr Lys Leu Leu Arg Glu 
                165                 170                 175     

Lys Trp Glu Ile Pro Cys Leu Leu Val Leu Ala Ile Leu Met Lys Leu 
            180                 185                 190         

His Gly Glu Arg Lys Pro 
        195             

<210>   1757
<211>   183
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1757
gtgggagata ccttgtttat tagtcctcgc tatcctaatg aagctacatg gagagaggaa   60
gccctaaaag aattgccaga ctattttgat actatttttt tagaaaactt tggccatgag   120
ctttatactc aagcacctaa agaaatcgct agtctaatga atgagtggct cgcttatttt   180
cta                                                                 183

<210>   1758
<211>   61
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902847 (2.E-31)

<400>   1758
Met Gly Asp Thr Leu Phe Ile Ser Pro Arg Tyr Pro Asn Glu Ala Thr 
1               5                   10                  15      

Trp Arg Glu Glu Ala Leu Lys Glu Leu Pro Asp Tyr Phe Asp Thr Ile 
            20                  25                  30          

Phe Leu Glu Asn Phe Gly His Glu Leu Tyr Thr Gln Ala Pro Lys Glu 
        35                  40                  45              

Ile Ala Ser Leu Met Asn Glu Trp Leu Ala Tyr Phe Leu 
    50                  55                  60      

<210>   1759
<211>   813
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1759
atgattcgat ttttagtttt agctggctat tttgaactga ctatttacct ccatctgtcg   60
ggcaaactaa accagtacat caacatgcac tattcctatc tggcctatat ctccatggtg   120
ctttctttta tcttggctat cgttcaattg tatatctgga tgaagcaagt caaaacccac   180
agtcatctga acagccgatt agccaagata acgagtattt ctcttctggc tattccactt   240
gtcatcggct taactttccc aactgttagc ttggattctc agactgtttc tgctaaaggt   300
tatcatttcc ccctatcgga aggaacggat ctagccattc agacaagcga agggacgaca   360
agccaatatt tgaaaccaga taccagttct tatttttcaa aatcagccta tgaaaaggaa   420
atgcgaacgg cggcggataa atacttatcc caagatagta ttcagatcac taatgaaaac   480
tatatggaag tcatggaggc tatctacgac tatccagatg agtttgaggg caagacaatc   540
cagtttacag gctttgtcta taacgacccc agtcatgcca atagtcaatt tctgttccga   600
ttcggcatta tccactgtat cgcagattct ggtgtctatg gattgctgac caagggcaat   660
acccggcagt atgaaaacaa cacttggata acagccaaag gaaaactggt caatcactac   720
cataaagaac tcaaacaaaa ccttccaacc ttggaaatcg acagctttac caaagtcgat   780
aaaccagaaa atccctatgt atatagagct ttt                                813

<210>   1760
<211>   271
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902848 (e-157)

<400>   1760
Met Ile Arg Phe Leu Val Leu Ala Gly Tyr Phe Glu Leu Thr Ile Tyr 
1               5                   10                  15      

Leu His Leu Ser Gly Lys Leu Asn Gln Tyr Ile Asn Met His Tyr Ser 
            20                  25                  30          

Tyr Leu Ala Tyr Ile Ser Met Val Leu Ser Phe Ile Leu Ala Ile Val 
        35                  40                  45              

Gln Leu Tyr Ile Trp Met Lys Gln Val Lys Thr His Ser His Leu Asn 
    50                  55                  60                  

Ser Arg Leu Ala Lys Ile Thr Ser Ile Ser Leu Leu Ala Ile Pro Leu 
65                  70                  75                  80  

Val Ile Gly Leu Thr Phe Pro Thr Val Ser Leu Asp Ser Gln Thr Val 
                85                  90                  95      

Ser Ala Lys Gly Tyr His Phe Pro Leu Ser Glu Gly Thr Asp Leu Ala 
            100                 105                 110         

Ile Gln Thr Ser Glu Gly Thr Thr Ser Gln Tyr Leu Lys Pro Asp Thr 
        115                 120                 125             

Ser Ser Tyr Phe Ser Lys Ser Ala Tyr Glu Lys Glu Met Arg Thr Ala 
    130                 135                 140                 

Ala Asp Lys Tyr Leu Ser Gln Asp Ser Ile Gln Ile Thr Asn Glu Asn 
145                 150                 155                 160 

Tyr Met Glu Val Met Glu Ala Ile Tyr Asp Tyr Pro Asp Glu Phe Glu 
                165                 170                 175     

Gly Lys Thr Ile Gln Phe Thr Gly Phe Val Tyr Asn Asp Pro Ser His 
            180                 185                 190         

Ala Asn Ser Gln Phe Leu Phe Arg Phe Gly Ile Ile His Cys Ile Ala 
        195                 200                 205             

Asp Ser Gly Val Tyr Gly Leu Leu Thr Lys Gly Asn Thr Arg Gln Tyr 
    210                 215                 220                 

Glu Asn Asn Thr Trp Ile Thr Ala Lys Gly Lys Leu Val Asn His Tyr 
225                 230                 235                 240 

His Lys Glu Leu Lys Gln Asn Leu Pro Thr Leu Glu Ile Asp Ser Phe 
                245                 250                 255     

Thr Lys Val Asp Lys Pro Glu Asn Pro Tyr Val Tyr Arg Ala Phe 
            260                 265                 270     

<210>   1761
<211>   903
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1761
atgactgctt ttcaacaact cccatctagt gtacttcaaa ctggagccat ttttctctcc   60
attatcattg aagcccttcc cttcgttctg ataggaagca ttgtctcagg gctgattgaa   120
gtttatatca cacctgacaa ggtttatcat tttctccctc gaaatcgttg ggggagaatc   180
ttttttggga cctttgtcgg tatacttttc ccttcttgtg aatgtggaat cgtccccatc   240
atcaatcgtt ttctggaaaa aaaggttcca agttacacgg ccgttccttt tcttgtgaca   300
gcacctgtta tcaatcccat tgttcttttt gcgacctatt ctgcctttgg caactccttc   360
catgtcgccc tattacgagc tctgggttcc attcttgtgg ctgtaatact aggaattttt   420
ctaggatttt tctggcaaga accgattcag aaagaaaatc gtctggcttg tcatgagcat   480
gatttttctt acttgagttc tgcaaaaaaa gtttttcaag tctttgtgca ggccattgat   540
gaattttttg atacggggcg ttatttggta tttggctgcc tctttgcttc tataatacag   600
gtctacgttc cgactcggat tctgacctct atcagtgcga cccctctttt tgccatcctg   660
ctcttgatga ttttagcctt tcttctttcg ctctgtagtg aggcggatgc ctttataggt   720
gcttctcttc tctcgagttt cggtttggca ccagttctgg cctttctcgt cattggtcca   780
atgctggata tcaaaaatat tctcatgatg aaaaattact tgaaagcacg atttatcagt   840
cacttcataa caattgtaac tcttgtcgtc ttagtctatt ctctcttgat tggagttatc   900
cta                                                                 903

<210>   1762
<211>   301
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902849 (e-168)

<400>   1762
Met Thr Ala Phe Gln Gln Leu Pro Ser Ser Val Leu Gln Thr Gly Ala 
1               5                   10                  15      

Ile Phe Leu Ser Ile Ile Ile Glu Ala Leu Pro Phe Val Leu Ile Gly 
            20                  25                  30          

Ser Ile Val Ser Gly Leu Ile Glu Val Tyr Ile Thr Pro Asp Lys Val 
        35                  40                  45              

Tyr His Phe Leu Pro Arg Asn Arg Trp Gly Arg Ile Phe Phe Gly Thr 
    50                  55                  60                  

Phe Val Gly Ile Leu Phe Pro Ser Cys Glu Cys Gly Ile Val Pro Ile 
65                  70                  75                  80  

Ile Asn Arg Phe Leu Glu Lys Lys Val Pro Ser Tyr Thr Ala Val Pro 
                85                  90                  95      

Phe Leu Val Thr Ala Pro Val Ile Asn Pro Ile Val Leu Phe Ala Thr 
            100                 105                 110         

Tyr Ser Ala Phe Gly Asn Ser Phe His Val Ala Leu Leu Arg Ala Leu 
        115                 120                 125             

Gly Ser Ile Leu Val Ala Val Ile Leu Gly Ile Phe Leu Gly Phe Phe 
    130                 135                 140                 

Trp Gln Glu Pro Ile Gln Lys Glu Asn Arg Leu Ala Cys His Glu His 
145                 150                 155                 160 

Asp Phe Ser Tyr Leu Ser Ser Ala Lys Lys Val Phe Gln Val Phe Val 
                165                 170                 175     

Gln Ala Ile Asp Glu Phe Phe Asp Thr Gly Arg Tyr Leu Val Phe Gly 
            180                 185                 190         

Cys Leu Phe Ala Ser Ile Ile Gln Val Tyr Val Pro Thr Arg Ile Leu 
        195                 200                 205             

Thr Ser Ile Ser Ala Thr Pro Leu Phe Ala Ile Leu Leu Leu Met Ile 
    210                 215                 220                 

Leu Ala Phe Leu Leu Ser Leu Cys Ser Glu Ala Asp Ala Phe Ile Gly 
225                 230                 235                 240 

Ala Ser Leu Leu Ser Ser Phe Gly Leu Ala Pro Val Leu Ala Phe Leu 
                245                 250                 255     

Val Ile Gly Pro Met Leu Asp Ile Lys Asn Ile Leu Met Met Lys Asn 
            260                 265                 270         

Tyr Leu Lys Ala Arg Phe Ile Ser His Phe Ile Thr Ile Val Thr Leu 
        275                 280                 285             

Val Val Leu Val Tyr Ser Leu Leu Ile Gly Val Ile Leu 
    290                 295                 300     

<210>   1763
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1763
atggctgtca aatttacaaa acgagacgac ttggacaaga tgtttgaaga gtttgctaaa   60
ctccctgatt tgaaacaagt tactttccct gatgacaaag agaaaaaagt caaagcagaa   120
aagaaaaac                                                           129


<210>   1764
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1764
Met Ala Val Lys Phe Thr Lys Arg Asp Asp Leu Asp Lys Met Phe Glu 
1               5                   10                  15      

Glu Phe Ala Lys Leu Pro Asp Leu Lys Gln Val Thr Phe Pro Asp Asp 
            20                  25                  30          

Lys Glu Lys Lys Val Lys Ala Glu Lys Lys Asn 
        35                  40              

<210>   1765
<211>   1365
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1765
ttgttacatc aaggagataa aaatagttta ttagagtctt tgtcaatagt ggagagacaa   60
acattaaaag atatagaagt tattattgta aatcaatcta cagaggagat agcttccatt   120
agccaacaga tgaatctatc atttaatatt aagattatag atgagaattc ttttgctgag   180
ttgtctgata tgattacagg agattatatt acgtttctat cttcaaatga ttcattattt   240
gattggacat ttgaaaagat gtatcatgcg ataaaattat ccgattctga tgttgttctt   300
ggtcattttg ctgatttggt tgatggagta ttttactttt atcctttttg gggggataat   360
tggttgacag aaaatttaac gaatgttcaa gttttacaaa agatggatga tacagatcat   420
cgaattagaa aacaatatcg ctcattattt ggaaaattat tcaatagtaa gcttttacga   480
aaaataaatc aatttgatat aaacaacctt atttggagac tttatattca ctctaaaact   540
gcaacctata ttaatttccc gacatatatc tataaacctg ttatagatgc taaacctcta   600
aaagactcct acaaaatcat attagaaaat tatgaaaata gaatcaaaga ttgcgccgtc   660
ttagaaaact atgatataga aagagcgaaa aaacaatata ttcaagaatt ggcaaatttt   720
agtgcttggt taaaaaatga cggtgaatat ttagattctg atattgttta tcataagtta   780
atagctgcag agaaaggaat tttccctttt cttgagcttg atagattaga ttttacgatt   840
ataagtaata attgtgttgg aggattaatt tataaacagc ttggttttca atatagaaca   900
ccttttgttg gtttatttat tcttcctgat gattattata aacttacaaa gcattttcgt   960
tattatatgg aacaagaact tgttttcgaa gaggaactta tttcaccgag ctggactcat   1020
gaagtttatc ctttggggca cttaggagat atagatattc attttctaca ttattctagt   1080
attgaagaag cacgaactaa gtgggaaaaa agaaaaaaac gcataaattg gaataatctt   1140
tattttaaat ttgataataa agattcagct agtgaagaaa ttttaaataa gatggataat   1200
cttccttatt ctaataaatt aattttagtc aatcgtccat ataaaaattt gaaaagtcaa   1260
tgtgttattc caggtcagga acatcttcca gaactggcta ttatgtctga tccattaaat   1320
acttttgata tcatggcttg gttaaaaaaa ggtggcaatg ctctt                   1365

<210>   1766
<211>   455
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902851 (0.E+01)

<400>   1766
Met Leu His Gln Gly Asp Lys Asn Ser Leu Leu Glu Ser Leu Ser Ile 
1               5                   10                  15      

Val Glu Arg Gln Thr Leu Lys Asp Ile Glu Val Ile Ile Val Asn Gln 
            20                  25                  30          

Ser Thr Glu Glu Ile Ala Ser Ile Ser Gln Gln Met Asn Leu Ser Phe 
        35                  40                  45              

Asn Ile Lys Ile Ile Asp Glu Asn Ser Phe Ala Glu Leu Ser Asp Met 
    50                  55                  60                  

Ile Thr Gly Asp Tyr Ile Thr Phe Leu Ser Ser Asn Asp Ser Leu Phe 
65                  70                  75                  80  

Asp Trp Thr Phe Glu Lys Met Tyr His Ala Ile Lys Leu Ser Asp Ser 
                85                  90                  95      

Asp Val Val Leu Gly His Phe Ala Asp Leu Val Asp Gly Val Phe Tyr 
            100                 105                 110         

Phe Tyr Pro Phe Trp Gly Asp Asn Trp Leu Thr Glu Asn Leu Thr Asn 
        115                 120                 125             

Val Gln Val Leu Gln Lys Met Asp Asp Thr Asp His Arg Ile Arg Lys 
    130                 135                 140                 

Gln Tyr Arg Ser Leu Phe Gly Lys Leu Phe Asn Ser Lys Leu Leu Arg 
145                 150                 155                 160 

Lys Ile Asn Gln Phe Asp Ile Asn Asn Leu Ile Trp Arg Leu Tyr Ile 
                165                 170                 175     

His Ser Lys Thr Ala Thr Tyr Ile Asn Phe Pro Thr Tyr Ile Tyr Lys 
            180                 185                 190         

Pro Val Ile Asp Ala Lys Pro Leu Lys Asp Ser Tyr Lys Ile Ile Leu 
        195                 200                 205             

Glu Asn Tyr Glu Asn Arg Ile Lys Asp Cys Ala Val Leu Glu Asn Tyr 
    210                 215                 220                 

Asp Ile Glu Arg Ala Lys Lys Gln Tyr Ile Gln Glu Leu Ala Asn Phe 
225                 230                 235                 240 

Ser Ala Trp Leu Lys Asn Asp Gly Glu Tyr Leu Asp Ser Asp Ile Val 
                245                 250                 255     

Tyr His Lys Leu Ile Ala Ala Glu Lys Gly Ile Phe Pro Phe Leu Glu 
            260                 265                 270         

Leu Asp Arg Leu Asp Phe Thr Ile Ile Ser Asn Asn Cys Val Gly Gly 
        275                 280                 285             

Leu Ile Tyr Lys Gln Leu Gly Phe Gln Tyr Arg Thr Pro Phe Val Gly 
    290                 295                 300                 

Leu Phe Ile Leu Pro Asp Asp Tyr Tyr Lys Leu Thr Lys His Phe Arg 
305                 310                 315                 320 

Tyr Tyr Met Glu Gln Glu Leu Val Phe Glu Glu Glu Leu Ile Ser Pro 
                325                 330                 335     

Ser Trp Thr His Glu Val Tyr Pro Leu Gly His Leu Gly Asp Ile Asp 
            340                 345                 350         

Ile His Phe Leu His Tyr Ser Ser Ile Glu Glu Ala Arg Thr Lys Trp 
        355                 360                 365             

Glu Lys Arg Lys Lys Arg Ile Asn Trp Asn Asn Leu Tyr Phe Lys Phe 
    370                 375                 380                 

Asp Asn Lys Asp Ser Ala Ser Glu Glu Ile Leu Asn Lys Met Asp Asn 
385                 390                 395                 400 

Leu Pro Tyr Ser Asn Lys Leu Ile Leu Val Asn Arg Pro Tyr Lys Asn 
                405                 410                 415     

Leu Lys Ser Gln Cys Val Ile Pro Gly Gln Glu His Leu Pro Glu Leu 
            420                 425                 430         

Ala Ile Met Ser Asp Pro Leu Asn Thr Phe Asp Ile Met Ala Trp Leu 
        435                 440                 445             

Lys Lys Gly Gly Asn Ala Leu 
    450                 455 

<210>   1767
<211>   2145
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1767
ttgtggtata atagatttat ggataaaaaa tatgaaaaaa tctctcagga tttgggagtg   60
acgttaaagc aaattgatac cgttctaagt ttgacagctg aaggggcgac tattcccttt   120
atcgcgcgtt atcgcaagga catgactggt agtctggatg aggtggcgat taaggctatt   180
attgatttgg ataaaagtct gacaaatctc aatgaccgta aggaagctgt cttagctaag   240
attcaagaac aaggtaagtt gaccaaggaa ttggaagaag ctatcttagt tgccgaaaaa   300
ttagcagacg ttgaagaact ctatcttcct tataaggaaa agcgtcgtac caaggcaacc   360
attgcccgtg aagctggact ctttcctctt gctcgcttga ttttgcagaa tatagttgac   420
ttagagaaag aagctgaaaa gttcgtctgt gaaggatttg cgactggcaa ggaagccttg   480
accggtgcag ttgatatttt ggtcgaagcc ttatcggaag atgtgacctt gcgttctatg   540
acttatcagg aagtgctgag acactctaaa cttacttctc aagccaagga tgaaagtctt   600
gatgaaaagc aggtttttca gatttattat gatttttcag agacagttgg aactatgcaa   660
ggctatcgta ccttggctct caatcgtggg gagaaacttg gtgtcttgaa gatcggtttt   720
gaacatgcga cggaccgtat tcttgccttc tttgctactc gtttcaaggt gaaaaatgct   780
tatattgatg aagttgttca gcaatccgtt aagaaaaagg tcttgcctgc tatcgagcgt   840
cgtattcgga cagaattaac tgagaaagct gaagaaggag ctatccaact tttttctgac   900
aatctgcgca atctcctctt ggttgctcca ctgaaagggc gcgtggttct tggatttgac   960
ccagcctttc gtacaggtgc caagctagct gtcgtggatg caacaggaaa aatgctgaca   1020
actcaggtta tttatcctgt taaaccagca tcagctcgtc aaatcgaaga agccaagaaa   1080
gatttagcag atttaattgg tcaatacggt gtagagatta ttgccattgg aaatggaacg   1140
gccagtcgtg aaagtgaagc ttttgtagcg gaagttctga aagatttccc tgaagtcagc   1200
tatgttatcg ttaatgaaag tggtgcttct gtctattctg ccagcgaact tgctcgtcag   1260
gagtttccag acttgaccgt tgaaaaacgc tctgccattt ctatcgcccg tcgtttgcaa   1320
gatcctcttg cggaattggt caaaatcgat cctaagtcaa ttggtgtcgg tcaataccaa   1380
cacgatgtca gtcagaagaa actatctgag agtctggact ttgttgtcga tacagtggtt   1440
aaccaagttg gtgtcaatgt caatacagct agcccagctc ttctttcaca cgtagctgga   1500
ctcaacaaaa ctatctctga aaatattgtc aaataccgcg aggaagaagg aaaaatcact   1560
tcacgcgccc aaatcaagaa agttcctcgt ctgggagcca aggcctttga gcaggctgct   1620
ggtttccttc gtatccctga aagtagcaat atccttgata atacaggagt tcacccagag   1680
aattacactg cagttaagga actcttcaaa cgtttagata ttaaagacct aaacgaagaa   1740
gcccaaagca aactcaagtc gctttcagtc aaggaaatgg cgcaagagtt agaccttggt   1800
ccagaaactc ttaaagatat cattgcagat cttctcaaac caggtcgaga tttccgtgat   1860
tcctttgacg cacctgtgct tcgccaagat gtcctagata tcaaggactt agtggttgga   1920
caaaagctag aaggagtggt gcgtaacgtt gttgatttcg gtgcttttgt tgatatcgga   1980
attcatgagg acggtctcat ccatatttcc catatgagtc gcaagtttat caaacaccct   2040
agtcaagtgg tggcagttgg agatttggtg agcgtttggg ttaagaaaat tgatactgaa   2100
cgtgaaaaag ttaatctgtc tctcctagct ccaaatgaaa ctgac                   2145

<210>   1768
<211>   715
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902852 (0.E+01)

<400>   1768
Met Trp Tyr Asn Arg Phe Met Asp Lys Lys Tyr Glu Lys Ile Ser Gln 
1               5                   10                  15      

Asp Leu Gly Val Thr Leu Lys Gln Ile Asp Thr Val Leu Ser Leu Thr 
            20                  25                  30          

Ala Glu Gly Ala Thr Ile Pro Phe Ile Ala Arg Tyr Arg Lys Asp Met 
        35                  40                  45              

Thr Gly Ser Leu Asp Glu Val Ala Ile Lys Ala Ile Ile Asp Leu Asp 
    50                  55                  60                  

Lys Ser Leu Thr Asn Leu Asn Asp Arg Lys Glu Ala Val Leu Ala Lys 
65                  70                  75                  80  

Ile Gln Glu Gln Gly Lys Leu Thr Lys Glu Leu Glu Glu Ala Ile Leu 
                85                  90                  95      

Val Ala Glu Lys Leu Ala Asp Val Glu Glu Leu Tyr Leu Pro Tyr Lys 
            100                 105                 110         

Glu Lys Arg Arg Thr Lys Ala Thr Ile Ala Arg Glu Ala Gly Leu Phe 
        115                 120                 125             

Pro Leu Ala Arg Leu Ile Leu Gln Asn Ile Val Asp Leu Glu Lys Glu 
    130                 135                 140                 

Ala Glu Lys Phe Val Cys Glu Gly Phe Ala Thr Gly Lys Glu Ala Leu 
145                 150                 155                 160 

Thr Gly Ala Val Asp Ile Leu Val Glu Ala Leu Ser Glu Asp Val Thr 
                165                 170                 175     

Leu Arg Ser Met Thr Tyr Gln Glu Val Leu Arg His Ser Lys Leu Thr 
            180                 185                 190         

Ser Gln Ala Lys Asp Glu Ser Leu Asp Glu Lys Gln Val Phe Gln Ile 
        195                 200                 205             

Tyr Tyr Asp Phe Ser Glu Thr Val Gly Thr Met Gln Gly Tyr Arg Thr 
    210                 215                 220                 

Leu Ala Leu Asn Arg Gly Glu Lys Leu Gly Val Leu Lys Ile Gly Phe 
225                 230                 235                 240 

Glu His Ala Thr Asp Arg Ile Leu Ala Phe Phe Ala Thr Arg Phe Lys 
                245                 250                 255     

Val Lys Asn Ala Tyr Ile Asp Glu Val Val Gln Gln Ser Val Lys Lys 
            260                 265                 270         

Lys Val Leu Pro Ala Ile Glu Arg Arg Ile Arg Thr Glu Leu Thr Glu 
        275                 280                 285             

Lys Ala Glu Glu Gly Ala Ile Gln Leu Phe Ser Asp Asn Leu Arg Asn 
    290                 295                 300                 

Leu Leu Leu Val Ala Pro Leu Lys Gly Arg Val Val Leu Gly Phe Asp 
305                 310                 315                 320 

Pro Ala Phe Arg Thr Gly Ala Lys Leu Ala Val Val Asp Ala Thr Gly 
                325                 330                 335     

Lys Met Leu Thr Thr Gln Val Ile Tyr Pro Val Lys Pro Ala Ser Ala 
            340                 345                 350         

Arg Gln Ile Glu Glu Ala Lys Lys Asp Leu Ala Asp Leu Ile Gly Gln 
        355                 360                 365             

Tyr Gly Val Glu Ile Ile Ala Ile Gly Asn Gly Thr Ala Ser Arg Glu 
    370                 375                 380                 

Ser Glu Ala Phe Val Ala Glu Val Leu Lys Asp Phe Pro Glu Val Ser 
385                 390                 395                 400 

Tyr Val Ile Val Asn Glu Ser Gly Ala Ser Val Tyr Ser Ala Ser Glu 
                405                 410                 415     

Leu Ala Arg Gln Glu Phe Pro Asp Leu Thr Val Glu Lys Arg Ser Ala 
            420                 425                 430         

Ile Ser Ile Ala Arg Arg Leu Gln Asp Pro Leu Ala Glu Leu Val Lys 
        435                 440                 445             

Ile Asp Pro Lys Ser Ile Gly Val Gly Gln Tyr Gln His Asp Val Ser 
    450                 455                 460                 

Gln Lys Lys Leu Ser Glu Ser Leu Asp Phe Val Val Asp Thr Val Val 
465                 470                 475                 480 

Asn Gln Val Gly Val Asn Val Asn Thr Ala Ser Pro Ala Leu Leu Ser 
                485                 490                 495     

His Val Ala Gly Leu Asn Lys Thr Ile Ser Glu Asn Ile Val Lys Tyr 
            500                 505                 510         

Arg Glu Glu Glu Gly Lys Ile Thr Ser Arg Ala Gln Ile Lys Lys Val 
        515                 520                 525             

Pro Arg Leu Gly Ala Lys Ala Phe Glu Gln Ala Ala Gly Phe Leu Arg 
    530                 535                 540                 

Ile Pro Glu Ser Ser Asn Ile Leu Asp Asn Thr Gly Val His Pro Glu 
545                 550                 555                 560 

Asn Tyr Thr Ala Val Lys Glu Leu Phe Lys Arg Leu Asp Ile Lys Asp 
                565                 570                 575     

Leu Asn Glu Glu Ala Gln Ser Lys Leu Lys Ser Leu Ser Val Lys Glu 
            580                 585                 590         

Met Ala Gln Glu Leu Asp Leu Gly Pro Glu Thr Leu Lys Asp Ile Ile 
        595                 600                 605             

Ala Asp Leu Leu Lys Pro Gly Arg Asp Phe Arg Asp Ser Phe Asp Ala 
    610                 615                 620                 

Pro Val Leu Arg Gln Asp Val Leu Asp Ile Lys Asp Leu Val Val Gly 
625                 630                 635                 640 

Gln Lys Leu Glu Gly Val Val Arg Asn Val Val Asp Phe Gly Ala Phe 
                645                 650                 655     

Val Asp Ile Gly Ile His Glu Asp Gly Leu Ile His Ile Ser His Met 
            660                 665                 670         

Ser Arg Lys Phe Ile Lys His Pro Ser Gln Val Val Ala Val Gly Asp 
        675                 680                 685             

Leu Val Ser Val Trp Val Lys Lys Ile Asp Thr Glu Arg Glu Lys Val 
    690                 695                 700                 

Asn Leu Ser Leu Leu Ala Pro Asn Glu Thr Asp 
705                 710                 715 

<210>   1769
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1769
atggattacg gtttgtacca tccttgccca atagtaactc caagccaatc aagctctatc   60
gttgccaatc ctgccagcaa aggtatcagc gtaagcgtag gattgatacc caacgctatc   120
gctgtggact ttgtcgagga aagttgctat                                    150

<210>   1770
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1770
Met Asp Tyr Gly Leu Tyr His Pro Cys Pro Ile Val Thr Pro Ser Gln 
1               5                   10                  15      

Ser Ser Ser Ile Val Ala Asn Pro Ala Ser Lys Gly Ile Ser Val Ser 
            20                  25                  30          

Val Gly Leu Ile Pro Asn Ala Ile Ala Val Asp Phe Val Glu Glu Ser 
        35                  40                  45              

Cys Tyr 
    50  

<210>   1771
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1771
atgaaactga ctgattacgt caagcaggtt tcactagaag acttcggcag accttttatc   60
catcatgtcc agtggaatag gcgtctacgt tcgacaggtg ggcgattttt ccccaaagat   120
gggcatttgg attttaatcc caaggtttat caggaactgg ggttggacgt ttttaggaaa   180
attgtccgac atgaactctg tcattatcac ctctattttc aagggaaagg ctatcaacac   240
aaggatcggg attttaagga actgttgaaa gcagtggatg gattacggtt tgtaccatcc   300
ttgcccaata gtaactccaa gccaatcaag ctctatcgtt gccaatcctg ccagcaaagg   360
tatcagcgta agcgtaggat tgatacccaa cgctatcgct gtggactttg tcgaggaaag   420
ttgctattag taaatcagcc tgaggac                                       447

<210>   1772
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902853 (2.E-86)

<400>   1772
Met Lys Leu Thr Asp Tyr Val Lys Gln Val Ser Leu Glu Asp Phe Gly 
1               5                   10                  15      

Arg Pro Phe Ile His His Val Gln Trp Asn Arg Arg Leu Arg Ser Thr 
            20                  25                  30          

Gly Gly Arg Phe Phe Pro Lys Asp Gly His Leu Asp Phe Asn Pro Lys 
        35                  40                  45              

Val Tyr Gln Glu Leu Gly Leu Asp Val Phe Arg Lys Ile Val Arg His 
    50                  55                  60                  

Glu Leu Cys His Tyr His Leu Tyr Phe Gln Gly Lys Gly Tyr Gln His 
65                  70                  75                  80  

Lys Asp Arg Asp Phe Lys Glu Leu Leu Lys Ala Val Asp Gly Leu Arg 
                85                  90                  95      

Phe Val Pro Ser Leu Pro Asn Ser Asn Ser Lys Pro Ile Lys Leu Tyr 
            100                 105                 110         

Arg Cys Gln Ser Cys Gln Gln Arg Tyr Gln Arg Lys Arg Arg Ile Asp 
        115                 120                 125             

Thr Gln Arg Tyr Arg Cys Gly Leu Cys Arg Gly Lys Leu Leu Leu Val 
    130                 135                 140                 

Asn Gln Pro Glu Asp 
145                 

<210>   1773
<211>   270
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1773
atgaacagta agttttataa aatgagacga aatcgcatga tttcaggagt tttagcaggt   60
ctgtcagaca agtggaactt tgatgttacc cttgtacgtt ttctgtttgc catttttaca   120
gtcgcaaact ttggacttgg ggtgattatc tatatcatcc tagcttctat catgccaacc   180
aaggaagaaa tcgaagcaga aatgtacgga acaggcccac gtaaacgcaa agaagctcaa   240
gccattgacg ataatgaagg ctggttttgg                                    270

<210>   1774
<211>   90
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902854 (4.E-49)

<400>   1774
Met Asn Ser Lys Phe Tyr Lys Met Arg Arg Asn Arg Met Ile Ser Gly 
1               5                   10                  15      

Val Leu Ala Gly Leu Ser Asp Lys Trp Asn Phe Asp Val Thr Leu Val 
            20                  25                  30          

Arg Phe Leu Phe Ala Ile Phe Thr Val Ala Asn Phe Gly Leu Gly Val 
        35                  40                  45              

Ile Ile Tyr Ile Ile Leu Ala Ser Ile Met Pro Thr Lys Glu Glu Ile 
    50                  55                  60                  

Glu Ala Glu Met Tyr Gly Thr Gly Pro Arg Lys Arg Lys Glu Ala Gln 
65                  70                  75                  80  

Ala Ile Asp Asp Asn Glu Gly Trp Phe Trp 
                85                  90  

<210>   1775
<211>   162
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1775
gtggatgaag ctggcgaaat attattaata ctattcaaaa atcaaagtgc aaactatatc   60
aacttcacat tgccgactaa attacagcct gcggctggct tcctagtttg cactttgatt   120
tttattgagt ataaaagtaa aaaagcttta aatcaagcag tt                      162

<210>   1776
<211>   54
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   1776
Met Asp Glu Ala Gly Glu Ile Leu Leu Ile Leu Phe Lys Asn Gln Ser 
1               5                   10                  15      

Ala Asn Tyr Ile Asn Phe Thr Leu Pro Thr Lys Leu Gln Pro Ala Ala 
            20                  25                  30          

Gly Phe Leu Val Cys Thr Leu Ile Phe Ile Glu Tyr Lys Ser Lys Lys 
        35                  40                  45              

Ala Leu Asn Gln Ala Val 
    50                  

<210>   1777
<211>   189
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1777
atgaaacaca aagaacatat actcatcgga cttctctatc tgctctctcc attcatcggt   60
cagctcttag ttgaacacac acactttatc agtacagaat ttaccggcac tgcttatgtt   120
atttgctggt tatcagttgt tatcagcatc caccattttt ccaaaaatgt attgtctcaa   180
cagcaaaaa                                                           189

<210>   1778
<211>   63
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902855 (1.E-32)

<400>   1778
Met Lys His Lys Glu His Ile Leu Ile Gly Leu Leu Tyr Leu Leu Ser 
1               5                   10                  15      

Pro Phe Ile Gly Gln Leu Leu Val Glu His Thr His Phe Ile Ser Thr 
            20                  25                  30          

Glu Phe Thr Gly Thr Ala Tyr Val Ile Cys Trp Leu Ser Val Val Ile 
        35                  40                  45              

Ser Ile His His Phe Ser Lys Asn Val Leu Ser Gln Gln Gln Lys 
    50                  55                  60              

<210>   1779
<211>   813
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1779
atgcactatg atgcaagcta catttcattt gatgggatat taagaaagga gattttcatg   60
acacttttag atgtaaaaca cgttcaaaaa atttataaaa cacgttttca gggcaaccaa   120
gtagaagccc tcaaggatat tcactttacc gtagaaaagg gtgactacgt tgccatcatg   180
ggtgagtctg gttctggtaa atcaactctt ctcaatattc tagctatgtt ggataaacca   240
agtcgtggtc aggtttactt gaatggaact gacaccgcaa ctattaaaaa ttcacaggct   300
tctagtttcc ggcgtgaaaa gctaggattt gtcttccaag actttaactt gctagatact   360
ctgtctgtta aggacaatat cttgcttccg cttgtcttgt caagaagacc tataacggag   420
atgatgaaga aattggtggt gacagctgag aatctgggta ttaaccaatt gcaagagaag   480
tacccttacg agatttctgg tggtcagaaa cagcgtgtag cagtagcccg cgccatcatc   540
acagaacctg aaattctcct tgcggacgag ccaacaggag cccttgattc caagtcatct   600
gcagccttac ttgatgtctt taatgaaatc aatgagcgtg ggcaaaccat cctcatggta   660
acccactcaa cagcagctgc tagcagggcc aagcgtgttc tctttatcaa agacggcatt   720
ctttacaacc aaatctaccg tggagagaag acagagcgtc agatgttcca agaaatctct   780
gataccttga ctgtcatggc aagcgaggtg aat                                813

<210>   1780
<211>   271
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902856 (e-138)

<400>   1780
Met His Tyr Asp Ala Ser Tyr Ile Ser Phe Asp Gly Ile Leu Arg Lys 
1               5                   10                  15      

Glu Ile Phe Met Thr Leu Leu Asp Val Lys His Val Gln Lys Ile Tyr 
            20                  25                  30          

Lys Thr Arg Phe Gln Gly Asn Gln Val Glu Ala Leu Lys Asp Ile His 
        35                  40                  45              

Phe Thr Val Glu Lys Gly Asp Tyr Val Ala Ile Met Gly Glu Ser Gly 
    50                  55                  60                  

Ser Gly Lys Ser Thr Leu Leu Asn Ile Leu Ala Met Leu Asp Lys Pro 
65                  70                  75                  80  

Ser Arg Gly Gln Val Tyr Leu Asn Gly Thr Asp Thr Ala Thr Ile Lys 
                85                  90                  95      

Asn Ser Gln Ala Ser Ser Phe Arg Arg Glu Lys Leu Gly Phe Val Phe 
            100                 105                 110         

Gln Asp Phe Asn Leu Leu Asp Thr Leu Ser Val Lys Asp Asn Ile Leu 
        115                 120                 125             

Leu Pro Leu Val Leu Ser Arg Arg Pro Ile Thr Glu Met Met Lys Lys 
    130                 135                 140                 

Leu Val Val Thr Ala Glu Asn Leu Gly Ile Asn Gln Leu Gln Glu Lys 
145                 150                 155                 160 

Tyr Pro Tyr Glu Ile Ser Gly Gly Gln Lys Gln Arg Val Ala Val Ala 
                165                 170                 175     

Arg Ala Ile Ile Thr Glu Pro Glu Ile Leu Leu Ala Asp Glu Pro Thr 
            180                 185                 190         

Gly Ala Leu Asp Ser Lys Ser Ser Ala Ala Leu Leu Asp Val Phe Asn 
        195                 200                 205             

Glu Ile Asn Glu Arg Gly Gln Thr Ile Leu Met Val Thr His Ser Thr 
    210                 215                 220                 

Ala Ala Ala Ser Arg Ala Lys Arg Val Leu Phe Ile Lys Asp Gly Ile 
225                 230                 235                 240 

Leu Tyr Asn Gln Ile Tyr Arg Gly Glu Lys Thr Glu Arg Gln Met Phe 
                245                 250                 255     

Gln Glu Ile Ser Asp Thr Leu Thr Val Met Ala Ser Glu Val Asn 
            260                 265                 270     

<210>   1781
<211>   1986
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1781
atgtttcgat taaccaataa gttagcggta tcgaacttga ttaaaaaccg caaactctac   60
tatccctttg cactggctgt tctcttggca gtcaccatca cctatctctt ttactcccta   120
accttcaatc caaagattgc ggaaatccgt ggaggaacca ccattcaagc aacacttgga   180
tttggtatgt ttgtcgttac ccttgcgtca gccattatcg tcctctatgc caatagtttt   240
gtcatgaaaa accgttccaa ggaactgggt atatatggca tgttaggctt ggagaagcgc   300
catctaatca gtatgacctt taaggagtta gtggtatttg ggattctaac tgttggagcg   360
ggtatcggta ttggagcctt gtttgacaag ttaattttcg ctttcctgct caaactaatg   420
aaactgaagg ttgagctggt tgctaccttc caaatgaatg ttgtcattgc agtacttgtt   480
gtctttggat tgattttcct aggcctcatg ttcctgaatg ctcttcgaat cgcccgtatg   540
aatgccctcc agctctcgcg tgagaaagca agcggagaga aaagaggtcg cttcctacct   600
ctccaaacga ttcttggttc cataagttta gggattggct attatcttgc ccttacggta   660
accgatcctc ttacagccct aacaactttc ttcctagctg ttttgctggt tatctttggt   720
acttatctat tgtttaatgc agggattaca gtcttcctac aaatcttaaa gaaaaacaag   780
aaatactatt accaacctaa taacctcata tctgtttcca acttgatttt ccgtatgaag   840
aaaaatgcgg ttggactagc aaccatcgct attttgtcaa caatggtttt ggtaaccatg   900
tcagcagcga caagcatttt caattccgca gaaagcttta aaaaagttct aaatcctcat   960
gattttgggg tttcagggca aaatgttgaa aaagaagatt tggacaaact cttgagccag   1020
tttgcaagtg acaaaggtta tagtgtcaaa gagaaagaag tacttcgtta cagtaacttt   1080
ggtattgcaa atcaagaagg aaccaagtta actatttttg aaaaaggaca aaaccgtgtc   1140
caacccacaa cagttttcat ggtatttgac caaaaagatt atgaaaatat gactggtcaa   1200
aaactgtctc tatcaggaaa tgaggtcggt ctctttgcca aaaatgacgg actgaaagga   1260
cagaaagctc taactctaaa tgatcatcaa ttttctgtca aagaagaatt taataaagat   1320
ttcattgtga accatgttcc aaataagttt aatatcttga ctactgatta caattacctt   1380
gttgttcctg atttacaagc ctttttggat caattcccag attcggctat ctataatcag   1440
ttttacggtg gtatgaatgt aaatgtcagt gaagaagaac aactcaaggt cgctgaggag   1500
tatgaaaact acctcaatca atttaatgct caattagaca cagaaggtag ctatgtttat   1560
ggtagcaatc tagcagatgc tagttctcag atgagtgccc tctttggtgg tgtcttcttt   1620
atcggtattt tcctatccat tatctttatg gtcggaactg ttctggtcat ctactacaaa   1680
caaatttctg aaggctacga agaccgtgaa cgctttatta tcttgcagaa agtcggtttg   1740
gaccaaaagc aaatcaagca aaccatcaac aaacaggttt taactgtttt cttccttcct   1800
ttgctctttg ccttcataca tctcgccttt gcctaccata tgcttagcct gattttaaaa   1860
gtgattggtg tactggatac gactatgatg ttgattgtga ccttgtctat ctgcgctatc   1920
ttcctcatcg cctatgtgct gattttcatg attacttcaa gaagttatcg caagattgtg   1980
caaatg                                                              1986

<210>   1782
<211>   662
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902857 (0.E+01)

<400>   1782
Met Phe Arg Leu Thr Asn Lys Leu Ala Val Ser Asn Leu Ile Lys Asn 
1               5                   10                  15      

Arg Lys Leu Tyr Tyr Pro Phe Ala Leu Ala Val Leu Leu Ala Val Thr 
            20                  25                  30          

Ile Thr Tyr Leu Phe Tyr Ser Leu Thr Phe Asn Pro Lys Ile Ala Glu 
        35                  40                  45              

Ile Arg Gly Gly Thr Thr Ile Gln Ala Thr Leu Gly Phe Gly Met Phe 
    50                  55                  60                  

Val Val Thr Leu Ala Ser Ala Ile Ile Val Leu Tyr Ala Asn Ser Phe 
65                  70                  75                  80  

Val Met Lys Asn Arg Ser Lys Glu Leu Gly Ile Tyr Gly Met Leu Gly 
                85                  90                  95      

Leu Glu Lys Arg His Leu Ile Ser Met Thr Phe Lys Glu Leu Val Val 
            100                 105                 110         

Phe Gly Ile Leu Thr Val Gly Ala Gly Ile Gly Ile Gly Ala Leu Phe 
        115                 120                 125             

Asp Lys Leu Ile Phe Ala Phe Leu Leu Lys Leu Met Lys Leu Lys Val 
    130                 135                 140                 

Glu Leu Val Ala Thr Phe Gln Met Asn Val Val Ile Ala Val Leu Val 
145                 150                 155                 160 

Val Phe Gly Leu Ile Phe Leu Gly Leu Met Phe Leu Asn Ala Leu Arg 
                165                 170                 175     

Ile Ala Arg Met Asn Ala Leu Gln Leu Ser Arg Glu Lys Ala Ser Gly 
            180                 185                 190         

Glu Lys Arg Gly Arg Phe Leu Pro Leu Gln Thr Ile Leu Gly Ser Ile 
        195                 200                 205             

Ser Leu Gly Ile Gly Tyr Tyr Leu Ala Leu Thr Val Thr Asp Pro Leu 
    210                 215                 220                 

Thr Ala Leu Thr Thr Phe Phe Leu Ala Val Leu Leu Val Ile Phe Gly 
225                 230                 235                 240 

Thr Tyr Leu Leu Phe Asn Ala Gly Ile Thr Val Phe Leu Gln Ile Leu 
                245                 250                 255     

Lys Lys Asn Lys Lys Tyr Tyr Tyr Gln Pro Asn Asn Leu Ile Ser Val 
            260                 265                 270         

Ser Asn Leu Ile Phe Arg Met Lys Lys Asn Ala Val Gly Leu Ala Thr 
        275                 280                 285             

Ile Ala Ile Leu Ser Thr Met Val Leu Val Thr Met Ser Ala Ala Thr 
    290                 295                 300                 

Ser Ile Phe Asn Ser Ala Glu Ser Phe Lys Lys Val Leu Asn Pro His 
305                 310                 315                 320 

Asp Phe Gly Val Ser Gly Gln Asn Val Glu Lys Glu Asp Leu Asp Lys 
                325                 330                 335     

Leu Leu Ser Gln Phe Ala Ser Asp Lys Gly Tyr Ser Val Lys Glu Lys 
            340                 345                 350         

Glu Val Leu Arg Tyr Ser Asn Phe Gly Ile Ala Asn Gln Glu Gly Thr 
        355                 360                 365             

Lys Leu Thr Ile Phe Glu Lys Gly Gln Asn Arg Val Gln Pro Thr Thr 
    370                 375                 380                 

Val Phe Met Val Phe Asp Gln Lys Asp Tyr Glu Asn Met Thr Gly Gln 
385                 390                 395                 400 

Lys Leu Ser Leu Ser Gly Asn Glu Val Gly Leu Phe Ala Lys Asn Asp 
                405                 410                 415     

Gly Leu Lys Gly Gln Lys Ala Leu Thr Leu Asn Asp His Gln Phe Ser 
            420                 425                 430         

Val Lys Glu Glu Phe Asn Lys Asp Phe Ile Val Asn His Val Pro Asn 
        435                 440                 445             

Lys Phe Asn Ile Leu Thr Thr Asp Tyr Asn Tyr Leu Val Val Pro Asp 
    450                 455                 460                 

Leu Gln Ala Phe Leu Asp Gln Phe Pro Asp Ser Ala Ile Tyr Asn Gln 
465                 470                 475                 480 

Phe Tyr Gly Gly Met Asn Val Asn Val Ser Glu Glu Glu Gln Leu Lys 
                485                 490                 495     

Val Ala Glu Glu Tyr Glu Asn Tyr Leu Asn Gln Phe Asn Ala Gln Leu 
            500                 505                 510         

Asp Thr Glu Gly Ser Tyr Val Tyr Gly Ser Asn Leu Ala Asp Ala Ser 
        515                 520                 525             

Ser Gln Met Ser Ala Leu Phe Gly Gly Val Phe Phe Ile Gly Ile Phe 
    530                 535                 540                 

Leu Ser Ile Ile Phe Met Val Gly Thr Val Leu Val Ile Tyr Tyr Lys 
545                 550                 555                 560 

Gln Ile Ser Glu Gly Tyr Glu Asp Arg Glu Arg Phe Ile Ile Leu Gln 
                565                 570                 575     

Lys Val Gly Leu Asp Gln Lys Gln Ile Lys Gln Thr Ile Asn Lys Gln 
            580                 585                 590         

Val Leu Thr Val Phe Phe Leu Pro Leu Leu Phe Ala Phe Ile His Leu 
        595                 600                 605             

Ala Phe Ala Tyr His Met Leu Ser Leu Ile Leu Lys Val Ile Gly Val 
    610                 615                 620                 

Leu Asp Thr Thr Met Met Leu Ile Val Thr Leu Ser Ile Cys Ala Ile 
625                 630                 635                 640 

Phe Leu Ile Ala Tyr Val Leu Ile Phe Met Ile Thr Ser Arg Ser Tyr 
                645                 650                 655     

Arg Lys Ile Val Gln Met 
            660         

<210>   1783
<211>   588
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1783
gtggttatcg gagttgccag tgccacgacc aatatctgga ttatcttttt atcaggtttt   60
acggctatct tagctggtgc cttttcaatg gctggtggag aatatgtatc cgtttcaact   120
ccaaaagata ccgaggaagc tgccgtttcg cgagaaaaac tcttgctaga ccaagatagg   180
gaactagcca aaaaatccct ctatgctgct tatatccaaa atggagaatt caaaacttct   240
gcccaactct tgaccaataa gatctttctt aaaaatccac tcaaggctct ggtagaggaa   300
aaatatggga ttgagtatga agaatttacc aatccttggc acgctgccat ttctagcttc   360
gttgcctttt tccttagaag tttgcctcca atgctgtcag tgaccatttt tccaagtgat   420
taccgcatcc ctgctaccgt ccttattgtc ggtgtggccc ttcttctcac tggttacaca   480
agtgctagac ttggaaaagc cccaaccaaa acagctatga ttcggaacct tgctattggt   540
ctcttgacca tgggagttac cttcctgctc ggacaacttt tcagcatt                588

<210>   1784
<211>   196
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   nodulin-related protein, truncation
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902858 (e-105)

<400>   1784
Met Val Ile Gly Val Ala Ser Ala Thr Thr Asn Ile Trp Ile Ile Phe 
1               5                   10                  15      

Leu Ser Gly Phe Thr Ala Ile Leu Ala Gly Ala Phe Ser Met Ala Gly 
            20                  25                  30          

Gly Glu Tyr Val Ser Val Ser Thr Pro Lys Asp Thr Glu Glu Ala Ala 
        35                  40                  45              

Val Ser Arg Glu Lys Leu Leu Leu Asp Gln Asp Arg Glu Leu Ala Lys 
    50                  55                  60                  

Lys Ser Leu Tyr Ala Ala Tyr Ile Gln Asn Gly Glu Phe Lys Thr Ser 
65                  70                  75                  80  

Ala Gln Leu Leu Thr Asn Lys Ile Phe Leu Lys Asn Pro Leu Lys Ala 
                85                  90                  95      

Leu Val Glu Glu Lys Tyr Gly Ile Glu Tyr Glu Glu Phe Thr Asn Pro 
            100                 105                 110         

Trp His Ala Ala Ile Ser Ser Phe Val Ala Phe Phe Leu Arg Ser Leu 
        115                 120                 125             

Pro Pro Met Leu Ser Val Thr Ile Phe Pro Ser Asp Tyr Arg Ile Pro 
    130                 135                 140                 

Ala Thr Val Leu Ile Val Gly Val Ala Leu Leu Leu Thr Gly Tyr Thr 
145                 150                 155                 160 

Ser Ala Arg Leu Gly Lys Ala Pro Thr Lys Thr Ala Met Ile Arg Asn 
                165                 170                 175     

Leu Ala Ile Gly Leu Leu Thr Met Gly Val Thr Phe Leu Leu Gly Gln 
            180                 185                 190         

Leu Phe Ser Ile 
        195     

<210>   1785
<211>   993
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1785
atgcaaaacc attatactac aaaaggcgaa catttgacaa tcgatagccg tcgcttaatc   60
gaaagatgga aaaaagaagg gaaatcaaat agagaaattg cctctctgct tggaaaagtt   120
cctcaaacta tccacactga aatcaagcgt gggacagtcc gacaatgtct tggaaaaggg   180
cgcttcaaag aggtttattc tgccgactat gctcaacagt cttatgaaaa caatcgcaag   240
cgctcggtca agaaatcaag cttgaccaag gaactaaagg aaaagattct ccactatcat   300
aaccaaaaat tttcgcctga aatgatggtg atggctaaag gggttaacgt gggaatttca   360
accatttact attggattca tcatggaaaa ttggggttaa gcaaacagga tctgctttac   420
cctagaaaag gaaaagcgct taagaaacag gccagcacca actttaaacc tgctggtcaa   480
tccatcgaac agcggcttga agctatcaat tttcgcttgg agaatgggca ttatgagatt   540
gatacagttc tacttacgag agcgaaaaac tactgcttgc ttgtcttgac ggatcgaaaa   600
agtagacatc agatcatccg attgattcca aataaaagtg ctgatgtggt caatcaggct   660
ctaaaactca tcttaaaaca acacaagatt ctttccatca cggcagataa tggaacggaa   720
ttcaatcgct tgtctaatgt attttctgag gagcacattt attatgcaca tccctatgcc   780
tcttgggaaa ggggaactaa tgagaatcac aacaggctca ttcgtagatg gttacctaag   840
ggaaccaaga aaatgactcc caaagaagtc gcattcatcg aaaagtggat taacaactat   900
cctaaaaaat gcttggacta caagtcaccc agagaagact tcttgatggc taacttgaac   960
ttgaaattta gcgtcagaaa caaatcacga aat                                993

<210>   1786
<211>   331
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1239, transposase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903410 (0.E+01)

<400>   1786
Met Gln Asn His Tyr Thr Thr Lys Gly Glu His Leu Thr Ile Asp Ser 
1               5                   10                  15      

Arg Arg Leu Ile Glu Arg Trp Lys Lys Glu Gly Lys Ser Asn Arg Glu 
            20                  25                  30          

Ile Ala Ser Leu Leu Gly Lys Val Pro Gln Thr Ile His Thr Glu Ile 
        35                  40                  45              

Lys Arg Gly Thr Val Arg Gln Cys Leu Gly Lys Gly Arg Phe Lys Glu 
    50                  55                  60                  

Val Tyr Ser Ala Asp Tyr Ala Gln Gln Ser Tyr Glu Asn Asn Arg Lys 
65                  70                  75                  80  

Arg Ser Val Lys Lys Ser Ser Leu Thr Lys Glu Leu Lys Glu Lys Ile 
                85                  90                  95      

Leu His Tyr His Asn Gln Lys Phe Ser Pro Glu Met Met Val Met Ala 
            100                 105                 110         

Lys Gly Val Asn Val Gly Ile Ser Thr Ile Tyr Tyr Trp Ile His His 
        115                 120                 125             

Gly Lys Leu Gly Leu Ser Lys Gln Asp Leu Leu Tyr Pro Arg Lys Gly 
    130                 135                 140                 

Lys Ala Leu Lys Lys Gln Ala Ser Thr Asn Phe Lys Pro Ala Gly Gln 
145                 150                 155                 160 

Ser Ile Glu Gln Arg Leu Glu Ala Ile Asn Phe Arg Leu Glu Asn Gly 
                165                 170                 175     

His Tyr Glu Ile Asp Thr Val Leu Leu Thr Arg Ala Lys Asn Tyr Cys 
            180                 185                 190         

Leu Leu Val Leu Thr Asp Arg Lys Ser Arg His Gln Ile Ile Arg Leu 
        195                 200                 205             

Ile Pro Asn Lys Ser Ala Asp Val Val Asn Gln Ala Leu Lys Leu Ile 
    210                 215                 220                 

Leu Lys Gln His Lys Ile Leu Ser Ile Thr Ala Asp Asn Gly Thr Glu 
225                 230                 235                 240 

Phe Asn Arg Leu Ser Asn Val Phe Ser Glu Glu His Ile Tyr Tyr Ala 
                245                 250                 255     

His Pro Tyr Ala Ser Trp Glu Arg Gly Thr Asn Glu Asn His Asn Arg 
            260                 265                 270         

Leu Ile Arg Arg Trp Leu Pro Lys Gly Thr Lys Lys Met Thr Pro Lys 
        275                 280                 285             

Glu Val Ala Phe Ile Glu Lys Trp Ile Asn Asn Tyr Pro Lys Lys Cys 
    290                 295                 300                 

Leu Asp Tyr Lys Ser Pro Arg Glu Asp Phe Leu Met Ala Asn Leu Asn 
305                 310                 315                 320 

Leu Lys Phe Ser Val Arg Asn Lys Ser Arg Asn 
                325                 330     

<210>   1787
<211>   1473
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1787
ttgaaagagt tagatcaaaa ccaagcccca atttatgagg ccttggtgaa gttacgcaag   60
aaaaggattg ttccctttga tgttccaggt cacaagcgtg gacggggaaa tccagaactt   120
gtcgaactct taggagaaaa atgtgtaggc attgatgtca attcgatgaa acctttggat   180
aatttaggcc atcctatttc gattattcgt gatgcagagg agctggctgc agatgctttt   240
ggagctagcc atgcctttct aatgattggt ggaacaactt catcggtgca gactatgatt   300
ctggcaacct gcaaggcagg agataagatt attctgccac gaaatgtcca taaatctgct   360
atcaatgcgt tggttctatg tggtgccatt cccatctata tcgagatgag tgtagatcct   420
aagattggta tcgctttagg tcttgaaaat gaccgagtag cacaggccat aaaggaccat   480
ccagatgcta aggctatcct aatcaacaat cctacttact acggcatctg ttcagaccta   540
aaggggttga cagaaatggc tcatgaagct ggcatgatgg ttttagtaga tgaagcccac   600
ggagcgcatt tgcatttcac tgataaactt ccaatttctg ctatggatgc aggggctgat   660
atggcagcag tttccatgca taagtctggt gggagtttga cccaaagctc cattttactt   720
atcggggagc agatgaattc tgaatacgtt cgtcagataa ttaacctgac ccagtctaca   780
tctgcctctt acttgttgat ggctagtttg gatatttcac gtcgcaactt ggcccttcgt   840
ggtaaagagt cgtttgagaa agtcattgag ctatctgagt atgcccgccg tgaaatcaat   900
gctatcggtg gctactatgc ctactcaaaa gagttaatag acggtgtttc ggtttgcgat   960
tttgacgtaa ctaagctgtc agtttacact cagggtattg gcttaacagg tatcgaggtt   1020
tatgacctct tgcgagacga atacgacatt cagatcgagt ttggtgatat cggcaatatc   1080
ttggcctata tttccatcgg cgaccgcatc caagacatcg agcgcttggt tggtgctctg   1140
gctgatatta agagactcta ttcaagagat ggaaaagatt tgatagcagg agaatatatt   1200
cagcccgagt tagtgctgtc tccgcaagaa gccttctatt cagaaagaaa aagtttaact   1260
ttggatgatt ctgttggaca ggtctgtgga gaatttgtta tgtgttaccc tccaggtatt   1320
cctatcttgg ctcctggtga acgcattaca cgagaaattg tcgactatat ccaattcgcc   1380
aaggaacgtg gttgctccct ccaagggacg gaagatccag aggtcaatca tatcaacgtt   1440
attaagagaa agacaaacta taagaaaagt caa                                1473

<210>   1788
<211>   491
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lysine decarboxylase (cad)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902860 (0.E+01)

<400>   1788
Met Lys Glu Leu Asp Gln Asn Gln Ala Pro Ile Tyr Glu Ala Leu Val 
1               5                   10                  15      

Lys Leu Arg Lys Lys Arg Ile Val Pro Phe Asp Val Pro Gly His Lys 
            20                  25                  30          

Arg Gly Arg Gly Asn Pro Glu Leu Val Glu Leu Leu Gly Glu Lys Cys 
        35                  40                  45              

Val Gly Ile Asp Val Asn Ser Met Lys Pro Leu Asp Asn Leu Gly His 
    50                  55                  60                  

Pro Ile Ser Ile Ile Arg Asp Ala Glu Glu Leu Ala Ala Asp Ala Phe 
65                  70                  75                  80  

Gly Ala Ser His Ala Phe Leu Met Ile Gly Gly Thr Thr Ser Ser Val 
                85                  90                  95      

Gln Thr Met Ile Leu Ala Thr Cys Lys Ala Gly Asp Lys Ile Ile Leu 
            100                 105                 110         

Pro Arg Asn Val His Lys Ser Ala Ile Asn Ala Leu Val Leu Cys Gly 
        115                 120                 125             

Ala Ile Pro Ile Tyr Ile Glu Met Ser Val Asp Pro Lys Ile Gly Ile 
    130                 135                 140                 

Ala Leu Gly Leu Glu Asn Asp Arg Val Ala Gln Ala Ile Lys Asp His 
145                 150                 155                 160 

Pro Asp Ala Lys Ala Ile Leu Ile Asn Asn Pro Thr Tyr Tyr Gly Ile 
                165                 170                 175     

Cys Ser Asp Leu Lys Gly Leu Thr Glu Met Ala His Glu Ala Gly Met 
            180                 185                 190         

Met Val Leu Val Asp Glu Ala His Gly Ala His Leu His Phe Thr Asp 
        195                 200                 205             

Lys Leu Pro Ile Ser Ala Met Asp Ala Gly Ala Asp Met Ala Ala Val 
    210                 215                 220                 

Ser Met His Lys Ser Gly Gly Ser Leu Thr Gln Ser Ser Ile Leu Leu 
225                 230                 235                 240 

Ile Gly Glu Gln Met Asn Ser Glu Tyr Val Arg Gln Ile Ile Asn Leu 
                245                 250                 255     

Thr Gln Ser Thr Ser Ala Ser Tyr Leu Leu Met Ala Ser Leu Asp Ile 
            260                 265                 270         

Ser Arg Arg Asn Leu Ala Leu Arg Gly Lys Glu Ser Phe Glu Lys Val 
        275                 280                 285             

Ile Glu Leu Ser Glu Tyr Ala Arg Arg Glu Ile Asn Ala Ile Gly Gly 
    290                 295                 300                 

Tyr Tyr Ala Tyr Ser Lys Glu Leu Ile Asp Gly Val Ser Val Cys Asp 
305                 310                 315                 320 

Phe Asp Val Thr Lys Leu Ser Val Tyr Thr Gln Gly Ile Gly Leu Thr 
                325                 330                 335     

Gly Ile Glu Val Tyr Asp Leu Leu Arg Asp Glu Tyr Asp Ile Gln Ile 
            340                 345                 350         

Glu Phe Gly Asp Ile Gly Asn Ile Leu Ala Tyr Ile Ser Ile Gly Asp 
        355                 360                 365             

Arg Ile Gln Asp Ile Glu Arg Leu Val Gly Ala Leu Ala Asp Ile Lys 
    370                 375                 380                 

Arg Leu Tyr Ser Arg Asp Gly Lys Asp Leu Ile Ala Gly Glu Tyr Ile 
385                 390                 395                 400 

Gln Pro Glu Leu Val Leu Ser Pro Gln Glu Ala Phe Tyr Ser Glu Arg 
                405                 410                 415     

Lys Ser Leu Thr Leu Asp Asp Ser Val Gly Gln Val Cys Gly Glu Phe 
            420                 425                 430         

Val Met Cys Tyr Pro Pro Gly Ile Pro Ile Leu Ala Pro Gly Glu Arg 
        435                 440                 445             

Ile Thr Arg Glu Ile Val Asp Tyr Ile Gln Phe Ala Lys Glu Arg Gly 
    450                 455                 460                 

Cys Ser Leu Gln Gly Thr Glu Asp Pro Glu Val Asn His Ile Asn Val 
465                 470                 475                 480 

Ile Lys Arg Lys Thr Asn Tyr Lys Lys Ser Gln 
                485                 490     

<210>   1789
<211>   714
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1789
atgctttatg tgggcattga tgtcgctaaa aataaacacg atgttacagc cttgaatgtt   60
ccaggaaaaa ctgttcttaa accactcact ttttcaaata ataaagctgg ttttgaactc   120
ttagatctgt ctcttcgaca gctcaaccaa gactgtctca tcgctcttga aaataccgga   180
cattatgcct ttaatctact gaacttcctg catgaacaag gatataaagt ttacacctac   240
aatcctttgc tcatcaagaa atttgccaaa tcattatcac ttcgcaaaac taaaacggat   300
aagaaagacg ctcatggcat cgctcttaaa cttctttctg accccaatcg tgaacaattt   360
caacacgata atcggcaagt agaactaaaa atactggcta gacatattca tcgtctcaag   420
aaaaaacagt ctgattggaa agtacaatac actcgttgtc ttgatatcat ctttcctgag   480
ttggataaaa tcgttggaaa gcattcagaa tatacctacc aactcttgac acgctaccct   540
aatcctcaga aaaggcttga ggcaggattt gataagctga tagaaattaa gcgattgacc   600
gcttctaatt caagggcttt ttgccgtgct ctaaaatcat cgccaaatca tcaaattgaa   660
ataagaaata gtttagataa aactattgac ttttcttata gtttgtcttt ctct         714

<210>   1790
<211>   238
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pilin gene inverting-related protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902862 (5.E-78)

<400>   1790
Met Leu Tyr Val Gly Ile Asp Val Ala Lys Asn Lys His Asp Val Thr 
1               5                   10                  15      

Ala Leu Asn Val Pro Gly Lys Thr Val Leu Lys Pro Leu Thr Phe Ser 
            20                  25                  30          

Asn Asn Lys Ala Gly Phe Glu Leu Leu Asp Leu Ser Leu Arg Gln Leu 
        35                  40                  45              

Asn Gln Asp Cys Leu Ile Ala Leu Glu Asn Thr Gly His Tyr Ala Phe 
    50                  55                  60                  

Asn Leu Leu Asn Phe Leu His Glu Gln Gly Tyr Lys Val Tyr Thr Tyr 
65                  70                  75                  80  

Asn Pro Leu Leu Ile Lys Lys Phe Ala Lys Ser Leu Ser Leu Arg Lys 
                85                  90                  95      

Thr Lys Thr Asp Lys Lys Asp Ala His Gly Ile Ala Leu Lys Leu Leu 
            100                 105                 110         

Ser Asp Pro Asn Arg Glu Gln Phe Gln His Asp Asn Arg Gln Val Glu 
        115                 120                 125             

Leu Lys Ile Leu Ala Arg His Ile His Arg Leu Lys Lys Lys Gln Ser 
    130                 135                 140                 

Asp Trp Lys Val Gln Tyr Thr Arg Cys Leu Asp Ile Ile Phe Pro Glu 
145                 150                 155                 160 

Leu Asp Lys Ile Val Gly Lys His Ser Glu Tyr Thr Tyr Gln Leu Leu 
                165                 170                 175     

Thr Arg Tyr Pro Asn Pro Gln Lys Arg Leu Glu Ala Gly Phe Asp Lys 
            180                 185                 190         

Leu Ile Glu Ile Lys Arg Leu Thr Ala Ser Asn Ser Arg Ala Phe Cys 
        195                 200                 205             

Arg Ala Leu Lys Ser Ser Pro Asn His Gln Ile Glu Ile Arg Asn Ser 
    210                 215                 220                 

Leu Asp Lys Thr Ile Asp Phe Ser Tyr Ser Leu Ser Phe Ser 
225                 230                 235             

<210>   1791
<211>   858
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1791
atggatttat ggttttctga agttcatact ccagatgtca aattgtctct gagaacagcc   60
aagcaacttt acgctggaaa aagtgaatgg caggatatcg aagtcttgga tacgccagct   120
tttgggaaaa tactgatttt aaatggccat gtcttgttct cagatgcgga tgatttcgtc   180
tacaatgaaa tgaccgttca cgttcccatg gctgtccacc caaatccaaa gaaagtattg   240
gttattgggg gtggtgacgg cggtgttgcc caagtattaa ccctctatcc tgaactggag   300
caaattgata ttgtggaacc ggatgagatg ttggtcgagg tctgtcgtga gtatttccca   360
gactttgctg cagggctaga tgatcctcgt gttaccattt actaccaaaa tgggctacgc   420
tttttgcgaa actgcgaaga tgattacgat attatcatca acgatgcgac agatccattt   480
ggccatacgg aaggactctt taccaaggaa ttctacggca atagttatcg agctctgaag   540
gaagacggca tcatgattta ccagcatggg agtcccttct ttgacgagga tgagtcggcc   600
tgccgaagca tgcaccgcaa ggtcaatcaa gcctttccaa tcagtcgggt ttatcaggcc   660
catattccaa ctagcccagc tggctattgg ttgtttggat ttgcatcgaa aaaataccac   720
cctgtcaaag attttgacaa ggaaggctgg aaaaaacgcc agcttttcac agaatactac   780
actgcaaact tacacgtggg agcctttatg ttgcccaagt atgttgagga cattttagaa   840
gaagaggaag gaaaaaaa                                                 858

<210>   1792
<211>   286
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spermidine synthase (speE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902863 (e-173)

<400>   1792
Met Asp Leu Trp Phe Ser Glu Val His Thr Pro Asp Val Lys Leu Ser 
1               5                   10                  15      

Leu Arg Thr Ala Lys Gln Leu Tyr Ala Gly Lys Ser Glu Trp Gln Asp 
            20                  25                  30          

Ile Glu Val Leu Asp Thr Pro Ala Phe Gly Lys Ile Leu Ile Leu Asn 
        35                  40                  45              

Gly His Val Leu Phe Ser Asp Ala Asp Asp Phe Val Tyr Asn Glu Met 
    50                  55                  60                  

Thr Val His Val Pro Met Ala Val His Pro Asn Pro Lys Lys Val Leu 
65                  70                  75                  80  

Val Ile Gly Gly Gly Asp Gly Gly Val Ala Gln Val Leu Thr Leu Tyr 
                85                  90                  95      

Pro Glu Leu Glu Gln Ile Asp Ile Val Glu Pro Asp Glu Met Leu Val 
            100                 105                 110         

Glu Val Cys Arg Glu Tyr Phe Pro Asp Phe Ala Ala Gly Leu Asp Asp 
        115                 120                 125             

Pro Arg Val Thr Ile Tyr Tyr Gln Asn Gly Leu Arg Phe Leu Arg Asn 
    130                 135                 140                 

Cys Glu Asp Asp Tyr Asp Ile Ile Ile Asn Asp Ala Thr Asp Pro Phe 
145                 150                 155                 160 

Gly His Thr Glu Gly Leu Phe Thr Lys Glu Phe Tyr Gly Asn Ser Tyr 
                165                 170                 175     

Arg Ala Leu Lys Glu Asp Gly Ile Met Ile Tyr Gln His Gly Ser Pro 
            180                 185                 190         

Phe Phe Asp Glu Asp Glu Ser Ala Cys Arg Ser Met His Arg Lys Val 
        195                 200                 205             

Asn Gln Ala Phe Pro Ile Ser Arg Val Tyr Gln Ala His Ile Pro Thr 
    210                 215                 220                 

Ser Pro Ala Gly Tyr Trp Leu Phe Gly Phe Ala Ser Lys Lys Tyr His 
225                 230                 235                 240 

Pro Val Lys Asp Phe Asp Lys Glu Gly Trp Lys Lys Arg Gln Leu Phe 
                245                 250                 255     

Thr Glu Tyr Tyr Thr Ala Asn Leu His Val Gly Ala Phe Met Leu Pro 
            260                 265                 270         

Lys Tyr Val Glu Asp Ile Leu Glu Glu Glu Glu Gly Lys Lys 
        275                 280                 285     

<210>   1793
<211>   1257
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1793
atgagtcgtt tactagttat tggttgtggg ggcgttgccc aagttgctat ttcaaagatt   60
tgtcaagata gcgaaacatt tacagagatt atgattgcta gccgtaccaa gtcaaaatgc   120
gatgacttga aagcgaagct agaaggcaaa acaagtacta aaattgaaac tgcagcactt   180
gatgctgaca aggttgaaga agtgattgcc ctgattgaaa gctacaaacc agaagctgtt   240
ttgaatgtag ctctgcctta tcaagattta accattatgg atgcttgttt ggcaacaggt   300
gttcactata tcgatacagc caactacgaa gcagaagaca cagaagaccc tgagtggcgt   360
gctatctacg aaaaacgttg taaggaactt ggttttacag cctactttga ctactcatgg   420
cagtgggctt atcaagagaa attcaaagaa gcaggcttga ctgctcttct tggttctggt   480
tttgacccag gtgtaactag tgtcttttca gcttatgccc tcaaacacta ttttgatgaa   540
atccattata tcgacatttt agactgtaat ggcggtgacc acggttatcc atttgcaacc   600
aactttaatc cagaaattaa tctccgtgag gtttctgcgc caggttctta ctgggaagat   660
gggaaatggg tcgaagtcga agctatgtct atcaagcgtg agtatgattt ccctcaagtt   720
ggacaaaaag atatgtatct ccttcaccat gaagaaatcg aatcattggc caagaacatt   780
ccaggtgtca aacgcattcg tttctttatg acttttggtc aatcttactt gacgcacatg   840
aaatgtcttg aaaatgttgg actccttcgt acggatacca ttaactttaa cggccaagaa   900
attgttccaa ttcaattttt gaaagccttg cttccagatc ctgccagtct tgggccacgt   960
acagtcggaa aaaccaatat tggatgtatc tttacaggtg tcaaagacgg tgtcaaaaag   1020
actatctata tctacaatgt ctgcgaccat caggaatgtt acgcagaggt tggttcgcaa   1080
gctatttctt atacgacagg agttccagcc atgattggga caaaattagt catgaacgga   1140
acttggaaac aagctggagt gtataacctt gaggagttag atccagatcc attcatggaa   1200
gctttgaatg agtatggttt gccatgggtt gtggttgaaa atccacaaat ggtggac      1257

<210>   1794
<211>   419
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902864 (0.E+01)

<400>   1794
Met Ser Arg Leu Leu Val Ile Gly Cys Gly Gly Val Ala Gln Val Ala 
1               5                   10                  15      

Ile Ser Lys Ile Cys Gln Asp Ser Glu Thr Phe Thr Glu Ile Met Ile 
            20                  25                  30          

Ala Ser Arg Thr Lys Ser Lys Cys Asp Asp Leu Lys Ala Lys Leu Glu 
        35                  40                  45              

Gly Lys Thr Ser Thr Lys Ile Glu Thr Ala Ala Leu Asp Ala Asp Lys 
    50                  55                  60                  

Val Glu Glu Val Ile Ala Leu Ile Glu Ser Tyr Lys Pro Glu Ala Val 
65                  70                  75                  80  

Leu Asn Val Ala Leu Pro Tyr Gln Asp Leu Thr Ile Met Asp Ala Cys 
                85                  90                  95      

Leu Ala Thr Gly Val His Tyr Ile Asp Thr Ala Asn Tyr Glu Ala Glu 
            100                 105                 110         

Asp Thr Glu Asp Pro Glu Trp Arg Ala Ile Tyr Glu Lys Arg Cys Lys 
        115                 120                 125             

Glu Leu Gly Phe Thr Ala Tyr Phe Asp Tyr Ser Trp Gln Trp Ala Tyr 
    130                 135                 140                 

Gln Glu Lys Phe Lys Glu Ala Gly Leu Thr Ala Leu Leu Gly Ser Gly 
145                 150                 155                 160 

Phe Asp Pro Gly Val Thr Ser Val Phe Ser Ala Tyr Ala Leu Lys His 
                165                 170                 175     

Tyr Phe Asp Glu Ile His Tyr Ile Asp Ile Leu Asp Cys Asn Gly Gly 
            180                 185                 190         

Asp His Gly Tyr Pro Phe Ala Thr Asn Phe Asn Pro Glu Ile Asn Leu 
        195                 200                 205             

Arg Glu Val Ser Ala Pro Gly Ser Tyr Trp Glu Asp Gly Lys Trp Val 
    210                 215                 220                 

Glu Val Glu Ala Met Ser Ile Lys Arg Glu Tyr Asp Phe Pro Gln Val 
225                 230                 235                 240 

Gly Gln Lys Asp Met Tyr Leu Leu His His Glu Glu Ile Glu Ser Leu 
                245                 250                 255     

Ala Lys Asn Ile Pro Gly Val Lys Arg Ile Arg Phe Phe Met Thr Phe 
            260                 265                 270         

Gly Gln Ser Tyr Leu Thr His Met Lys Cys Leu Glu Asn Val Gly Leu 
        275                 280                 285             

Leu Arg Thr Asp Thr Ile Asn Phe Asn Gly Gln Glu Ile Val Pro Ile 
    290                 295                 300                 

Gln Phe Leu Lys Ala Leu Leu Pro Asp Pro Ala Ser Leu Gly Pro Arg 
305                 310                 315                 320 

Thr Val Gly Lys Thr Asn Ile Gly Cys Ile Phe Thr Gly Val Lys Asp 
                325                 330                 335     

Gly Val Lys Lys Thr Ile Tyr Ile Tyr Asn Val Cys Asp His Gln Glu 
            340                 345                 350         

Cys Tyr Ala Glu Val Gly Ser Gln Ala Ile Ser Tyr Thr Thr Gly Val 
        355                 360                 365             

Pro Ala Met Ile Gly Thr Lys Leu Val Met Asn Gly Thr Trp Lys Gln 
    370                 375                 380                 

Ala Gly Val Tyr Asn Leu Glu Glu Leu Asp Pro Asp Pro Phe Met Glu 
385                 390                 395                 400 

Ala Leu Asn Glu Tyr Gly Leu Pro Trp Val Val Val Glu Asn Pro Gln 
                405                 410                 415     

Met Val Asp 
            

<210>   1795
<211>   1125
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1795
atgaagttag aacaagtacc aacaccagcc tatgttattg acttggccaa gttagaagct   60
aattgccgca ttctacaata tgtacaagaa gaggccggtt gcaaggtctt gcttgcccag   120
aaggcatatt ccctctacaa aacttatccc ttgattagcc agtatctatc aggtacgaca   180
gctagtggac tctatgaggc caaattggca agggaagaat ttcctggtga agtccatgta   240
tttgcgcctg ctttcaagga tgcagacttg gaggaattgc tagagataat ggaccatata   300
gtctttaact cagagagaca gttgcgtaaa cacggtccgc gttgtcgaga ggctggtgtc   360
agtgttggtt tgcgcctcaa ccctcagtgt tcaactcaag gagatcacgc gctctatgac   420

ccttgtgcac caggttctcg ctttggagtt actatagaca agattccgag tgatttgcta   480
gatttggttg acggacttca ttttcatacc ctttgcgagc agggagcaga tgatttacaa   540
acaactttga aagcagtaga agaacagttt ggtccctact tacatgaggt aaaatggctc   600
aatatgggtg gtggtcatca tattacaaga gaaggttacg atgtggattt gctgatttca   660
gaaatcaagc gtatccgaaa aacttacaat cttgaaatct atatcgagcc tggtgaagcc   720
attgcgctta atgcgggtta tttagcaact gaggtattag atattgtaga aaacggtatg   780
gaaatcttgg ttttagacgc ctctgcgacc tgccatatgc ctgatgtact tgagatgccc   840
tatcgtccac ctttgagaaa tggctttgag tcacaggaaa aagcccatac ctacagactt   900
tcttctaata cctgtctgac gggcgatgtg attggtgatt atagttttga aaatccagtc   960
caaatcggag acagacttta ttttcaagac atggccattt attcttttgt caaaaataat   1020
acctttaatg gtattggatt gccaagtctc tatctcatgg acgaacaggg agactgtagc   1080
ttactcaaag cttttggcta tcaagacttt aaagggagat tatca                   1125

<210>   1796
<211>   375
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   carboxynorspermidine decarboxylase (nspC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902865 (0.E+01)

<400>   1796
Met Lys Leu Glu Gln Val Pro Thr Pro Ala Tyr Val Ile Asp Leu Ala 
1               5                   10                  15      

Lys Leu Glu Ala Asn Cys Arg Ile Leu Gln Tyr Val Gln Glu Glu Ala 
            20                  25                  30          

Gly Cys Lys Val Leu Leu Ala Gln Lys Ala Tyr Ser Leu Tyr Lys Thr 
        35                  40                  45              

Tyr Pro Leu Ile Ser Gln Tyr Leu Ser Gly Thr Thr Ala Ser Gly Leu 
    50                  55                  60                  

Tyr Glu Ala Lys Leu Ala Arg Glu Glu Phe Pro Gly Glu Val His Val 
65                  70                  75                  80  

Phe Ala Pro Ala Phe Lys Asp Ala Asp Leu Glu Glu Leu Leu Glu Ile 
                85                  90                  95      

Met Asp His Ile Val Phe Asn Ser Glu Arg Gln Leu Arg Lys His Gly 
            100                 105                 110         

Pro Arg Cys Arg Glu Ala Gly Val Ser Val Gly Leu Arg Leu Asn Pro 
        115                 120                 125             

Gln Cys Ser Thr Gln Gly Asp His Ala Leu Tyr Asp Pro Cys Ala Pro 
    130                 135                 140                 

Gly Ser Arg Phe Gly Val Thr Ile Asp Lys Ile Pro Ser Asp Leu Leu 
145                 150                 155                 160 

Asp Leu Val Asp Gly Leu His Phe His Thr Leu Cys Glu Gln Gly Ala 
                165                 170                 175     

Asp Asp Leu Gln Thr Thr Leu Lys Ala Val Glu Glu Gln Phe Gly Pro 
            180                 185                 190         

Tyr Leu His Glu Val Lys Trp Leu Asn Met Gly Gly Gly His His Ile 
        195                 200                 205             

Thr Arg Glu Gly Tyr Asp Val Asp Leu Leu Ile Ser Glu Ile Lys Arg 
    210                 215                 220                 

Ile Arg Lys Thr Tyr Asn Leu Glu Ile Tyr Ile Glu Pro Gly Glu Ala 
225                 230                 235                 240 

Ile Ala Leu Asn Ala Gly Tyr Leu Ala Thr Glu Val Leu Asp Ile Val 
                245                 250                 255     

Glu Asn Gly Met Glu Ile Leu Val Leu Asp Ala Ser Ala Thr Cys His 
            260                 265                 270         

Met Pro Asp Val Leu Glu Met Pro Tyr Arg Pro Pro Leu Arg Asn Gly 
        275                 280                 285             

Phe Glu Ser Gln Glu Lys Ala His Thr Tyr Arg Leu Ser Ser Asn Thr 
    290                 295                 300                 

Cys Leu Thr Gly Asp Val Ile Gly Asp Tyr Ser Phe Glu Asn Pro Val 
305                 310                 315                 320 

Gln Ile Gly Asp Arg Leu Tyr Phe Gln Asp Met Ala Ile Tyr Ser Phe 
                325                 330                 335     

Val Lys Asn Asn Thr Phe Asn Gly Ile Gly Leu Pro Ser Leu Tyr Leu 
            340                 345                 350         

Met Asp Glu Gln Gly Asp Cys Ser Leu Leu Lys Ala Phe Gly Tyr Gln 
        355                 360                 365             

Asp Phe Lys Gly Arg Leu Ser 
    370                 375 

<210>   1797
<211>   1083
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1797
atgatggaca gtccaaaaaa attaggctat cacatgccag cagagtacga accccatcat   60
ggtaccctca tgatatggcc gactcgacca ggatcatggc cttttcaagg aaaggctgct   120
aaaagagcat ttactcagat tatcgagacc atagcagaag gggaaagagt ctatcttttg   180
gtggagcagg cctatctatc tgaagcccaa tcctatcttg gagacaaggt tgtttattta   240
gacattccca ccaatgatgc ctgggcgcgt gatactggcc caaccattct cgtcaatgat   300
aaaggtaaga aattagccgt ggattgggcc ttcaatgctt ggggaggcac ctatgatggt   360
ctttatcaag attatgaaga ggatgaccaa gtagccagtc gttttgctga ggccttggaa   420
aggcctgtct atgatgctaa accttttgta ctggaaggag gcgcaatcca tagcgatggt   480
caaggaacta ttctcgtaac tgaaagttgc ttgcttagtc ctggtcgcaa tcctaacttg   540
actaaagagg agattgaaaa cacattatta gaaagtcttg gtgctgaaaa agttatttgg   600
cttccttatg gtatttatca ggatgaaacc aatgaacacg tcgataatgt tgctgccttt   660
gttggtcctg ctgagcttgt tttggcttgg acagatgacg aaaatgatcc ccagtatgcc   720
atgtcaaaag cagatctcga actcttagaa caggaaacag atgcaaaagg ttgtcacttc   780
accattcata aattgcctat ccctgcagtt cgacaagttg tgacagaaga agatttgcca   840
ggctacatct atgaagaagg agaagaaaag cgatacgcag gtgaacgact agcagcttcc   900
tacgtaaact tttatatcgc caacaaggct gtcttggttc cacagtttga ggatgtaaac   960
gaccaagtgg ccttagatat cctcagcaag tgtttcccag accgtaaagt tgtcggaata   1020
ccagccagag atattctctt aggtggtggc aatatccact gtatcaccca acaaattcca   1080
gaa                                                                 1083

<210>   1798
<211>   361
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902866 (0.E+01)

<400>   1798
Met Met Asp Ser Pro Lys Lys Leu Gly Tyr His Met Pro Ala Glu Tyr 
1               5                   10                  15      

Glu Pro His His Gly Thr Leu Met Ile Trp Pro Thr Arg Pro Gly Ser 
            20                  25                  30          

Trp Pro Phe Gln Gly Lys Ala Ala Lys Arg Ala Phe Thr Gln Ile Ile 
        35                  40                  45              

Glu Thr Ile Ala Glu Gly Glu Arg Val Tyr Leu Leu Val Glu Gln Ala 
    50                  55                  60                  

Tyr Leu Ser Glu Ala Gln Ser Tyr Leu Gly Asp Lys Val Val Tyr Leu 
65                  70                  75                  80  

Asp Ile Pro Thr Asn Asp Ala Trp Ala Arg Asp Thr Gly Pro Thr Ile 
                85                  90                  95      

Leu Val Asn Asp Lys Gly Lys Lys Leu Ala Val Asp Trp Ala Phe Asn 
            100                 105                 110         

Ala Trp Gly Gly Thr Tyr Asp Gly Leu Tyr Gln Asp Tyr Glu Glu Asp 
        115                 120                 125             

Asp Gln Val Ala Ser Arg Phe Ala Glu Ala Leu Glu Arg Pro Val Tyr 
    130                 135                 140                 

Asp Ala Lys Pro Phe Val Leu Glu Gly Gly Ala Ile His Ser Asp Gly 
145                 150                 155                 160 

Gln Gly Thr Ile Leu Val Thr Glu Ser Cys Leu Leu Ser Pro Gly Arg 
                165                 170                 175     

Asn Pro Asn Leu Thr Lys Glu Glu Ile Glu Asn Thr Leu Leu Glu Ser 
            180                 185                 190         

Leu Gly Ala Glu Lys Val Ile Trp Leu Pro Tyr Gly Ile Tyr Gln Asp 
        195                 200                 205             

Glu Thr Asn Glu His Val Asp Asn Val Ala Ala Phe Val Gly Pro Ala 
    210                 215                 220                 

Glu Leu Val Leu Ala Trp Thr Asp Asp Glu Asn Asp Pro Gln Tyr Ala 
225                 230                 235                 240 

Met Ser Lys Ala Asp Leu Glu Leu Leu Glu Gln Glu Thr Asp Ala Lys 
                245                 250                 255     

Gly Cys His Phe Thr Ile His Lys Leu Pro Ile Pro Ala Val Arg Gln 
            260                 265                 270         

Val Val Thr Glu Glu Asp Leu Pro Gly Tyr Ile Tyr Glu Glu Gly Glu 
        275                 280                 285             

Glu Lys Arg Tyr Ala Gly Glu Arg Leu Ala Ala Ser Tyr Val Asn Phe 
    290                 295                 300                 

Tyr Ile Ala Asn Lys Ala Val Leu Val Pro Gln Phe Glu Asp Val Asn 
305                 310                 315                 320 

Asp Gln Val Ala Leu Asp Ile Leu Ser Lys Cys Phe Pro Asp Arg Lys 
                325                 330                 335     

Val Val Gly Ile Pro Ala Arg Asp Ile Leu Leu Gly Gly Gly Asn Ile 
            340                 345                 350         

His Cys Ile Thr Gln Gln Ile Pro Glu 
        355                 360     

<210>   1799
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1799
atgagaaatg taagagttgc aaccattcag atgcaatgcg ctaaggatgt ggcaacaaat   60
atccaaaccg cagagcgttt agtacgtcag gctgctgagc aaggagccca aattattctc   120
ttgcccgagt tgtttgaaca tccctatttc tgtcaggaac gtcagtatga ctactaccag   180
tatgcccaat ctgtagcgga aaatactgcc attcagcatt ttaaggtgat tgctaaggaa   240
ctacaagttg ttttaccaat cagtttctat gaaaaagatg gtaatgtctt gtataactct   300
attgccgtca ttgatgcaga tggggaagtg ctgggcgttt atcgaaagac ccatatacca   360
gatgaccatt attatcaaga aaaattctat ttcacgcctg gtaacactgg tttcaaggtc   420
tggaatactc gctatgctaa gattggtatc ggtatctgtt gggatcaatg gttccctgaa   480
acagcgcgct gtcttgcatt gaatggtgct gaattgctct tttatcctac agctatcggt   540
tcagagccaa ttttggatac agatagttgt ggtcactggc aacgtactat gcaagggcac   600
gcagcagcga atattgttcc agtcatcgca gccaatcgtt atggtttaga ggaggttact   660
cctagtgagg aaaatggcgg acagagctcc agtcttgact tctacggttc ctcctttatg   720
acggatgaaa caggagctat tctagaacga gctgaaagac aagaagaagc tgttctgtta   780
gctacttatg acctagacaa gggagcaagt gaacgcctaa actggggctt gtttcgagat   840
agaagaccag aaatgtatag acaaattaca gat                                873

<210>   1800
<211>   291
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   carbon-nitrogen hydrolase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902867 (e-172)

<400>   1800
Met Arg Asn Val Arg Val Ala Thr Ile Gln Met Gln Cys Ala Lys Asp 
1               5                   10                  15      

Val Ala Thr Asn Ile Gln Thr Ala Glu Arg Leu Val Arg Gln Ala Ala 
            20                  25                  30          

Glu Gln Gly Ala Gln Ile Ile Leu Leu Pro Glu Leu Phe Glu His Pro 
        35                  40                  45              

Tyr Phe Cys Gln Glu Arg Gln Tyr Asp Tyr Tyr Gln Tyr Ala Gln Ser 
    50                  55                  60                  

Val Ala Glu Asn Thr Ala Ile Gln His Phe Lys Val Ile Ala Lys Glu 
65                  70                  75                  80  

Leu Gln Val Val Leu Pro Ile Ser Phe Tyr Glu Lys Asp Gly Asn Val 
                85                  90                  95      

Leu Tyr Asn Ser Ile Ala Val Ile Asp Ala Asp Gly Glu Val Leu Gly 
            100                 105                 110         

Val Tyr Arg Lys Thr His Ile Pro Asp Asp His Tyr Tyr Gln Glu Lys 
        115                 120                 125             

Phe Tyr Phe Thr Pro Gly Asn Thr Gly Phe Lys Val Trp Asn Thr Arg 
    130                 135                 140                 

Tyr Ala Lys Ile Gly Ile Gly Ile Cys Trp Asp Gln Trp Phe Pro Glu 
145                 150                 155                 160 

Thr Ala Arg Cys Leu Ala Leu Asn Gly Ala Glu Leu Leu Phe Tyr Pro 
                165                 170                 175     

Thr Ala Ile Gly Ser Glu Pro Ile Leu Asp Thr Asp Ser Cys Gly His 
            180                 185                 190         

Trp Gln Arg Thr Met Gln Gly His Ala Ala Ala Asn Ile Val Pro Val 
        195                 200                 205             

Ile Ala Ala Asn Arg Tyr Gly Leu Glu Glu Val Thr Pro Ser Glu Glu 
    210                 215                 220                 

Asn Gly Gly Gln Ser Ser Ser Leu Asp Phe Tyr Gly Ser Ser Phe Met 
225                 230                 235                 240 

Thr Asp Glu Thr Gly Ala Ile Leu Glu Arg Ala Glu Arg Gln Glu Glu 
                245                 250                 255     

Ala Val Leu Leu Ala Thr Tyr Asp Leu Asp Lys Gly Ala Ser Glu Arg 
            260                 265                 270         

Leu Asn Trp Gly Leu Phe Arg Asp Arg Arg Pro Glu Met Tyr Arg Gln 
        275                 280                 285             

Ile Thr Asp 
    290     

<210>   1801
<211>   807
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1801
atgattaaac tactagcctt ggatatggac ggcaccctcc tcaatgaagc caaggaaatc   60
ccacaagctc acattactgc tattcacaaa gccattgaaa aaggtgtcaa actggttctc   120
tgtacgggtc gccccctttt cggtgtcctc ccctactaca aaaaactgga gcttgacctc   180
cagaacgaat atattattgt taacaacggt tgttcaactc accagaccag tgattggagt   240
ctagttgact ggaaagaact gagtccagct gacatcgaat acctctatga ccttgctgaa   300
aagagtgatg ttcagttgac actttttgac gagtcacatt attttgttct cggtgacaag   360
cccaatcaag ttattgaaaa tgatgctaaa ctagtatttt cagacctgac tgaaatttct   420
cttgaagaag cgactagtgg aaagttccgg atgttccaag gtatgttttt aggaacaaaa   480
gaacaaacag acgattttga gcagcgtttt gctgaagagc tttgccaacg attcagtgga   540
gttcgttcgc agcctgtcat ttatgaagca atgccgcttg gaacgacaaa ggctactgct   600
ctttcacgac tagctgagat tttgaagatt gattcctcag agattatggc catgggcgat   660
gctaataacg atatcgaaat gctccagttt gcagggcttg ggattgcaat gggaaatgcc   720
agcgattata tcaaatctct tgcggatgcc gttacctcaa gcaacgaaga agacggcgtt   780
gcgcgtgcta ttgagaaata tattcta                                       807

<210>   1802
<211>   269
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Cof family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902868 (e-149)

<400>   1802
Met Ile Lys Leu Leu Ala Leu Asp Met Asp Gly Thr Leu Leu Asn Glu 
1               5                   10                  15      

Ala Lys Glu Ile Pro Gln Ala His Ile Thr Ala Ile His Lys Ala Ile 
            20                  25                  30          

Glu Lys Gly Val Lys Leu Val Leu Cys Thr Gly Arg Pro Leu Phe Gly 
        35                  40                  45              

Val Leu Pro Tyr Tyr Lys Lys Leu Glu Leu Asp Leu Gln Asn Glu Tyr 
    50                  55                  60                  

Ile Ile Val Asn Asn Gly Cys Ser Thr His Gln Thr Ser Asp Trp Ser 
65                  70                  75                  80  

Leu Val Asp Trp Lys Glu Leu Ser Pro Ala Asp Ile Glu Tyr Leu Tyr 
                85                  90                  95      

Asp Leu Ala Glu Lys Ser Asp Val Gln Leu Thr Leu Phe Asp Glu Ser 
            100                 105                 110         

His Tyr Phe Val Leu Gly Asp Lys Pro Asn Gln Val Ile Glu Asn Asp 
        115                 120                 125             

Ala Lys Leu Val Phe Ser Asp Leu Thr Glu Ile Ser Leu Glu Glu Ala 
    130                 135                 140                 

Thr Ser Gly Lys Phe Arg Met Phe Gln Gly Met Phe Leu Gly Thr Lys 
145                 150                 155                 160 

Glu Gln Thr Asp Asp Phe Glu Gln Arg Phe Ala Glu Glu Leu Cys Gln 
                165                 170                 175     

Arg Phe Ser Gly Val Arg Ser Gln Pro Val Ile Tyr Glu Ala Met Pro 
            180                 185                 190         

Leu Gly Thr Thr Lys Ala Thr Ala Leu Ser Arg Leu Ala Glu Ile Leu 
        195                 200                 205             

Lys Ile Asp Ser Ser Glu Ile Met Ala Met Gly Asp Ala Asn Asn Asp 
    210                 215                 220                 

Ile Glu Met Leu Gln Phe Ala Gly Leu Gly Ile Ala Met Gly Asn Ala 
225                 230                 235                 240 

Ser Asp Tyr Ile Lys Ser Leu Ala Asp Ala Val Thr Ser Ser Asn Glu 
                245                 250                 255     

Glu Asp Gly Val Ala Arg Ala Ile Glu Lys Tyr Ile Leu 
            260                 265                 

<210>   1803
<211>   219
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1803
atgattttaa tgacaaaaaa tataaatcta acaaatgaag aattagagct gatacaaggt   60
ggagcagatc catatggtaa aaatcctaat ggtaggtacg attgggaaat agaaccagta   120
ttaactctgc tggttcatgg attttgtccc agaggcacct atgattcagg atatattgga   180
ggaggtaatc atctttgcaa aggaagtgct gcgagattt                          219

<210>   1804
<211>   73
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902869 (5.E-39)

<400>   1804
Met Ile Leu Met Thr Lys Asn Ile Asn Leu Thr Asn Glu Glu Leu Glu 
1               5                   10                  15      

Leu Ile Gln Gly Gly Ala Asp Pro Tyr Gly Lys Asn Pro Asn Gly Arg 
            20                  25                  30          

Tyr Asp Trp Glu Ile Glu Pro Val Leu Thr Leu Leu Val His Gly Phe 
        35                  40                  45              

Cys Pro Arg Gly Thr Tyr Asp Ser Gly Tyr Ile Gly Gly Gly Asn His 
    50                  55                  60                  

Leu Cys Lys Gly Ser Ala Ala Arg Phe 
65                  70              

<210>   1805
<211>   669
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1805
atgaaaaaac gagctattca aattttacta gcattgtcct taatttttta caaatcaact   60
tggttttgga ggcttttcaa ttatctcgca aagccctatc taccagcaag tcgtgaattt   120
tttcagattc tgcttttgat ggagagcgga gttcttttct tagcggtcat ctatctactg   180
gtttttgcag gaaagaaaat ttttcatttc aagtggcagc tgaggtactt catctacctt   240
ttactgggct acatcatttc atatatgtct gacttcctct tttcgtattt catatccctg   300
tcttcaaatc agatttcttt gaatgaaacg gtagaaatga tggggagaca ggagttccct   360
tatttcttgc tcatcgtttg cttcatcgcc cctattgctg aggaattgat ttatcgaggt   420
gtgcttatga caaccttttt caaaaactca ccttggtacg gagatgtttt gctttctgct   480
attattttcg gttatattca tatcaatttt gctttaactc ctcttgcttt tttcatttat   540
gctagtggag gtcttatttt agctctattg tatcgcatga ctaaaaatct ctactatcca   600
atactagttc atattctcat taatatcact gccttctggg atgtgtggtt gctcctattt   660
tcaggaagt                                                           669

<210>   1806
<211>   223
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902870 (e-126)

<400>   1806
Met Lys Lys Arg Ala Ile Gln Ile Leu Leu Ala Leu Ser Leu Ile Phe 
1               5                   10                  15      

Tyr Lys Ser Thr Trp Phe Trp Arg Leu Phe Asn Tyr Leu Ala Lys Pro 
            20                  25                  30          

Tyr Leu Pro Ala Ser Arg Glu Phe Phe Gln Ile Leu Leu Leu Met Glu 
        35                  40                  45              

Ser Gly Val Leu Phe Leu Ala Val Ile Tyr Leu Leu Val Phe Ala Gly 
    50                  55                  60                  

Lys Lys Ile Phe His Phe Lys Trp Gln Leu Arg Tyr Phe Ile Tyr Leu 
65                  70                  75                  80  

Leu Leu Gly Tyr Ile Ile Ser Tyr Met Ser Asp Phe Leu Phe Ser Tyr 
                85                  90                  95      

Phe Ile Ser Leu Ser Ser Asn Gln Ile Ser Leu Asn Glu Thr Val Glu 
            100                 105                 110         

Met Met Gly Arg Gln Glu Phe Pro Tyr Phe Leu Leu Ile Val Cys Phe 
        115                 120                 125             

Ile Ala Pro Ile Ala Glu Glu Leu Ile Tyr Arg Gly Val Leu Met Thr 
    130                 135                 140                 

Thr Phe Phe Lys Asn Ser Pro Trp Tyr Gly Asp Val Leu Leu Ser Ala 
145                 150                 155                 160 

Ile Ile Phe Gly Tyr Ile His Ile Asn Phe Ala Leu Thr Pro Leu Ala 
                165                 170                 175     

Phe Phe Ile Tyr Ala Ser Gly Gly Leu Ile Leu Ala Leu Leu Tyr Arg 
            180                 185                 190         

Met Thr Lys Asn Leu Tyr Tyr Pro Ile Leu Val His Ile Leu Ile Asn 
        195                 200                 205             

Ile Thr Ala Phe Trp Asp Val Trp Leu Leu Leu Phe Ser Gly Ser 
    210                 215                 220             

<210>   1807
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1807
atgttcatct tctaccccca acttctttat cttttcatta taccatattt tagaagtttt   60
ccaaaaagga aaaaagaaca tcctattctt cttaactatc ttcactatct gcctttctca   120
agtcaacctt attttcaaaa tcaattcaaa aaaataactg gatacacacc actacaatat   180
cgaaaagaaa aacgt                                                    195

<210>   1808
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Similar to strain R6 sequence 15902871 (4.E-34)

<400>   1808
Met Phe Ile Phe Tyr Pro Gln Leu Leu Tyr Leu Phe Ile Ile Pro Tyr 
1               5                   10                  15      

Phe Arg Ser Phe Pro Lys Arg Lys Lys Glu His Pro Ile Leu Leu Asn 
            20                  25                  30          

Tyr Leu His Tyr Leu Pro Phe Ser Ser Gln Pro Tyr Phe Gln Asn Gln 
        35                  40                  45              

Phe Lys Lys Ile Thr Gly Tyr Thr Pro Leu Gln Tyr Arg Lys Glu Lys 
    50                  55                  60                  

Arg 
65  

<210>   1809
<211>   906
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1809
atgaacattc aacaattacg ctatgttgtg gctattgcca atagtggtac ttttcgtgaa   60
gctgctgaaa agatgtatgt tagtcagccg agtctgtcta tttctgttcg tgatttggaa   120
aaagagttgg gctttaagat tttccgtcgg accagctcag ggactttctt gacccgtcgt   180
gggatggaat tttatgaaaa atcgcaagaa ttggttaaag gatttgatat ttttcaaaat   240
cagtatgcca atcctgaaga agaaaaagat gaattttctg ttgctagcca gcactatgac   300
ttcttgccac caactattac ggccttttca gagcgctatc ctgactataa gaacttccgt   360
atttttgaat caactactgt tcaaatatta gatgaagtgg cgcaagggca tagtgagatt   420
gggattatct acctcaacaa tcaaaataaa aaggggatta tgcaacgggt tgaaaaatta   480
ggtctggagg tcatcgaatt gattcctttc catacccata tttatctccg tgagggtcat   540
cctttagccc agaaagagga attagtcatg gaggatttag cggatttacc aacggttcgt   600
ttcactcaag agaaagacga gtacctttat tattcagaga actttgtcga taccagcgct   660
agctcacaga tgtttaatgt gacagaccgt gccaccttga atggtatttt ggagcggacg   720
gacgcctatg cgacaggttc tggattttta gatagtgaca gtgttaatgg cattacagtt   780
attcgtctca aggataacct agataaccgc atggtctatg ttaaacgtga agaagtggag   840
cttagtcaag ctgggactct cttcgtagaa gtcatgcaag aatattttga tcaaaagagg   900
aaatca                                                              906

<210>   1810
<211>   302
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, LysR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902872 (e-170)

<400>   1810
Met Asn Ile Gln Gln Leu Arg Tyr Val Val Ala Ile Ala Asn Ser Gly 
1               5                   10                  15      

Thr Phe Arg Glu Ala Ala Glu Lys Met Tyr Val Ser Gln Pro Ser Leu 
            20                  25                  30          

Ser Ile Ser Val Arg Asp Leu Glu Lys Glu Leu Gly Phe Lys Ile Phe 
        35                  40                  45              

Arg Arg Thr Ser Ser Gly Thr Phe Leu Thr Arg Arg Gly Met Glu Phe 
    50                  55                  60                  

Tyr Glu Lys Ser Gln Glu Leu Val Lys Gly Phe Asp Ile Phe Gln Asn 
65                  70                  75                  80  

Gln Tyr Ala Asn Pro Glu Glu Glu Lys Asp Glu Phe Ser Val Ala Ser 
                85                  90                  95      

Gln His Tyr Asp Phe Leu Pro Pro Thr Ile Thr Ala Phe Ser Glu Arg 
            100                 105                 110         

Tyr Pro Asp Tyr Lys Asn Phe Arg Ile Phe Glu Ser Thr Thr Val Gln 
        115                 120                 125             

Ile Leu Asp Glu Val Ala Gln Gly His Ser Glu Ile Gly Ile Ile Tyr 
    130                 135                 140                 

Leu Asn Asn Gln Asn Lys Lys Gly Ile Met Gln Arg Val Glu Lys Leu 
145                 150                 155                 160 

Gly Leu Glu Val Ile Glu Leu Ile Pro Phe His Thr His Ile Tyr Leu 
                165                 170                 175     

Arg Glu Gly His Pro Leu Ala Gln Lys Glu Glu Leu Val Met Glu Asp 
            180                 185                 190         

Leu Ala Asp Leu Pro Thr Val Arg Phe Thr Gln Glu Lys Asp Glu Tyr 
        195                 200                 205             

Leu Tyr Tyr Ser Glu Asn Phe Val Asp Thr Ser Ala Ser Ser Gln Met 
    210                 215                 220                 

Phe Asn Val Thr Asp Arg Ala Thr Leu Asn Gly Ile Leu Glu Arg Thr 
225                 230                 235                 240 

Asp Ala Tyr Ala Thr Gly Ser Gly Phe Leu Asp Ser Asp Ser Val Asn 
                245                 250                 255     

Gly Ile Thr Val Ile Arg Leu Lys Asp Asn Leu Asp Asn Arg Met Val 
            260                 265                 270         

Tyr Val Lys Arg Glu Glu Val Glu Leu Ser Gln Ala Gly Thr Leu Phe 
        275                 280                 285             

Val Glu Val Met Gln Glu Tyr Phe Asp Gln Lys Arg Lys Ser 
    290                 295                 300         

<210>   1811
<211>   459
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1811
atgaaaaaaa gagcaatagt ggcagtcatt gtactgcttt tgattgggct ggatcagttg   60
gtcaaatcct atatcgtcca gcagattcca ctgggtgaag tgcgctcctg gatccccaat   120
ttcgttagct tgacctacct gcaaaatcga ggtgcagcct tttctatctt acaagatcag   180
cagctgttat tcgctgtcat tactctggtt gtcgtgatag gtgccatttg gtatttacat   240
aaacacatgg aggactcatt ctggatggtc ttgggtttga ctctaataat cgcgggtggt   300
cttggaaact ttattgacag ggtcagtcag ggctttgttg tggatatgtt ccaccttgac   360
tttatcaact ttgcaatttt caatgtggca gatagctatc tgacggttgg agtgattatt   420
ttattgattg caatgctaaa agaggaaata aatggaaat                          459

<210>   1812
<211>   153
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lipoprotein signal peptidase (lspA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902873 (8.E-83)

<400>   1812
Met Lys Lys Arg Ala Ile Val Ala Val Ile Val Leu Leu Leu Ile Gly 
1               5                   10                  15      

Leu Asp Gln Leu Val Lys Ser Tyr Ile Val Gln Gln Ile Pro Leu Gly 
            20                  25                  30          

Glu Val Arg Ser Trp Ile Pro Asn Phe Val Ser Leu Thr Tyr Leu Gln 
        35                  40                  45              

Asn Arg Gly Ala Ala Phe Ser Ile Leu Gln Asp Gln Gln Leu Leu Phe 
    50                  55                  60                  

Ala Val Ile Thr Leu Val Val Val Ile Gly Ala Ile Trp Tyr Leu His 
65                  70                  75                  80  

Lys His Met Glu Asp Ser Phe Trp Met Val Leu Gly Leu Thr Leu Ile 
                85                  90                  95      

Ile Ala Gly Gly Leu Gly Asn Phe Ile Asp Arg Val Ser Gln Gly Phe 
            100                 105                 110         

Val Val Asp Met Phe His Leu Asp Phe Ile Asn Phe Ala Ile Phe Asn 
        115                 120                 125             

Val Ala Asp Ser Tyr Leu Thr Val Gly Val Ile Ile Leu Leu Ile Ala 
    130                 135                 140                 

Met Leu Lys Glu Glu Ile Asn Gly Asn 
145                 150             

<210>   1813
<211>   885
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1813
atggaaatta aaattgaaac tggtggtctg cgtttggata aggctttgtc agatttgtca   60
gaattatcac gtagtctcgc gaatgaacaa attaaatcag gccaggtctt ggtcaatggt   120
caagtcaaga aagctaaata cacagtccaa gagggtgatg tcgtcactta ccatgtgcca   180
gaaccagagg tattagagta tgtggctgag gatcttccgc tagaaatagt ctaccaagat   240
gaggatgtgg ctgtcgttaa caaacctcag ggaatggttg tgcacccgag tgctggtcat   300
accagtggaa ccctagtaaa tgccctcatg tatcatatta aggacttgtc gggtatcaat   360
ggggttctgc gtccagggat tgttcaccgt attgataagg atacgtcagg tcttctcatg   420
attgctaaaa acgatgatgc gcatctagca cttgcccaag aactcaagga taaaaagtct   480
ctccgcaaat attgggcgat tgttcatgga aatctaccta atgatcgtgg tgtaattgaa   540
gcgccgattg gccggagtga aaaagaccgt aagaaacagg ctgtaactgc taaagggaag   600
cctgcagtga cgcgttttca cgtcttggaa cgctttggcg attatagctt agtagagttg   660
caactggaga cagggcgcac tcatcaaatc cgtgtccaca tggcttatat cggccatcca   720
gtcgctggtg atgaggtcta tggtcctcgc aagactttga aaggacatgg acaatttctt   780
catgccaaga ctttaggttt tactcatccg agaacaggta agaccttgga atttaaagca   840
gatatcccag agatttttaa ggaaaccttg gagagattga gaaag                   885

<210>   1814
<211>   295
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal large subunit pseudouridine synthase D (rluD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902874 (e-169)

<400>   1814
Met Glu Ile Lys Ile Glu Thr Gly Gly Leu Arg Leu Asp Lys Ala Leu 
1               5                   10                  15      

Ser Asp Leu Ser Glu Leu Ser Arg Ser Leu Ala Asn Glu Gln Ile Lys 
            20                  25                  30          

Ser Gly Gln Val Leu Val Asn Gly Gln Val Lys Lys Ala Lys Tyr Thr 
        35                  40                  45              

Val Gln Glu Gly Asp Val Val Thr Tyr His Val Pro Glu Pro Glu Val 
    50                  55                  60                  

Leu Glu Tyr Val Ala Glu Asp Leu Pro Leu Glu Ile Val Tyr Gln Asp 
65                  70                  75                  80  

Glu Asp Val Ala Val Val Asn Lys Pro Gln Gly Met Val Val His Pro 
                85                  90                  95      

Ser Ala Gly His Thr Ser Gly Thr Leu Val Asn Ala Leu Met Tyr His 
            100                 105                 110         

Ile Lys Asp Leu Ser Gly Ile Asn Gly Val Leu Arg Pro Gly Ile Val 
        115                 120                 125             

His Arg Ile Asp Lys Asp Thr Ser Gly Leu Leu Met Ile Ala Lys Asn 
    130                 135                 140                 

Asp Asp Ala His Leu Ala Leu Ala Gln Glu Leu Lys Asp Lys Lys Ser 
145                 150                 155                 160 

Leu Arg Lys Tyr Trp Ala Ile Val His Gly Asn Leu Pro Asn Asp Arg 
                165                 170                 175     

Gly Val Ile Glu Ala Pro Ile Gly Arg Ser Glu Lys Asp Arg Lys Lys 
            180                 185                 190         

Gln Ala Val Thr Ala Lys Gly Lys Pro Ala Val Thr Arg Phe His Val 
        195                 200                 205             

Leu Glu Arg Phe Gly Asp Tyr Ser Leu Val Glu Leu Gln Leu Glu Thr 
    210                 215                 220                 

Gly Arg Thr His Gln Ile Arg Val His Met Ala Tyr Ile Gly His Pro 
225                 230                 235                 240 

Val Ala Gly Asp Glu Val Tyr Gly Pro Arg Lys Thr Leu Lys Gly His 
                245                 250                 255     

Gly Gln Phe Leu His Ala Lys Thr Leu Gly Phe Thr His Pro Arg Thr 
            260                 265                 270         

Gly Lys Thr Leu Glu Phe Lys Ala Asp Ile Pro Glu Ile Phe Lys Glu 
        275                 280                 285             

Thr Leu Glu Arg Leu Arg Lys 
    290                 295 

<210>   1815
<211>   1881
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1815
atgaaaaaga aattaactag tttagcactt gtaggcgctt ttttaggttt gtcatggtat   60
gggaatgttc aggctcaaga aagttcagga aataaaatcc actttatcaa tgttcaagaa   120
ggtggcagtg atgcgattat tcttgaaagc aatggacatt ttgccatggt ggatacagga   180
gaagattatg atttcccaga tggaagtgat tctcgctatc catggagaga aggaattgaa   240
acgtcttata agcatgttct aacagaccgt gtctttcgtc gtttgaagga attgggtgtc   300
caaaaacttg attttatttt ggtgacccat acccacagtg atcatattgg aaatgttgat   360
gaattactgt ctacctatcc agttgaccga gtctatctta agaaatatag tgatagtcgt   420
attactaatt ctgaacgtct atgggataat ctgtatggct atgataaggt tttacagact   480
gctgcagaaa aaggtgtttc agttattcaa aatatcacac aaggggatgc tcattttcag   540
tttggggaca tggatattca gctctataat tatgaaaatg aaactgattc atcgggtgaa   600
ttaaagaaaa tttgggatga caattccaat tccttgatta gcgtggtgaa agtcaatggc   660
aagaaaattt accttggggg cgatttagat aatgttcatg gagcagaaga caagtatggt   720
cctctcattg gaaaagttga tttgatgaag tttaatcatc accatgatac caacaaatca   780
aataccaagg atttcattaa aaatttgagt ccgagtttga ttgttcaaac ttcggatagt   840
ctaccttgga aaaatggtgt tgatagtgag tatgttaatt ggctcaaaga acgaggaatt   900
gagagaatca acgcagccag caaagactat gatgcaacag tttttgatat tcgaaaagac   960
ggttttgtca atatttcaac atcctacaag ccgattccaa gttttcaagc tggttggcat   1020
aagagtgcat atgggaactg gtggtatcaa gcgcctgatt ctacaggaga gtatgctgtc   1080
ggttggaatg aaatcgaagg tgaatggtat tactttaacc aaacgggtat cttgttacag   1140
aatcaatgga aaaaatggaa caatcattgg ttctatttga cagactctgg tgcttctgct   1200
aaaaattgga agaaaatcgc tggaatctgg tattatttta acaaagaaaa ccagatggaa   1260
attggttgga ttcaagataa agagcagtgg tattatttgg atgttgatgg ttctatgaag   1320
acaggatggc ttcaatatat ggggcaatgg tattactttg ctccatcagg ggaaatgaaa   1380
atgggctggg taaaagataa agaaacctgg tactatatgg attctactgg tgtcatgaag   1440
acaggtgaga tagaagttgc tggtcaacat tattatctgg aagattcagg agctatgaag   1500
caaggctggc ataaaaaggc aaatgattgg tatttctaca agacagacgg ttcacgagct   1560
gtgggttgga tcaaggacaa ggataaatgg tacttcttga aagaaaatgg tcaattactt   1620
gtgaacggta agacaccaga aggttatact gtggattcaa gtggtgcctg gttagtggat   1680
gtttcgatcg agaaatctgc tacaattaaa actacaagtc attcagaaat aaaagaatcc   1740
aaagaagtag tgaaaaagga tcttgaaaat aaagaaacga gtcaacatga aagtgttaca   1800
aatttttcaa ctagtcaaga tttgacatcc tcaacttcac aaagctctga aacgagtgta   1860
aacaaatcgg aatcagaaca g                                             1881

<210>   1816
<211>   627
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline binding protein E (cbpE)
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15902875 (0.E+01)

<400>   1816
Met Lys Lys Lys Leu Thr Ser Leu Ala Leu Val Gly Ala Phe Leu Gly 
1               5                   10                  15      

Leu Ser Trp Tyr Gly Asn Val Gln Ala Gln Glu Ser Ser Gly Asn Lys 
            20                  25                  30          

Ile His Phe Ile Asn Val Gln Glu Gly Gly Ser Asp Ala Ile Ile Leu 
        35                  40                  45              

Glu Ser Asn Gly His Phe Ala Met Val Asp Thr Gly Glu Asp Tyr Asp 
    50                  55                  60                  

Phe Pro Asp Gly Ser Asp Ser Arg Tyr Pro Trp Arg Glu Gly Ile Glu 
65                  70                  75                  80  

Thr Ser Tyr Lys His Val Leu Thr Asp Arg Val Phe Arg Arg Leu Lys 
                85                  90                  95      

Glu Leu Gly Val Gln Lys Leu Asp Phe Ile Leu Val Thr His Thr His 
            100                 105                 110         

Ser Asp His Ile Gly Asn Val Asp Glu Leu Leu Ser Thr Tyr Pro Val 
        115                 120                 125             

Asp Arg Val Tyr Leu Lys Lys Tyr Ser Asp Ser Arg Ile Thr Asn Ser 
    130                 135                 140                 

Glu Arg Leu Trp Asp Asn Leu Tyr Gly Tyr Asp Lys Val Leu Gln Thr 
145                 150                 155                 160 

Ala Ala Glu Lys Gly Val Ser Val Ile Gln Asn Ile Thr Gln Gly Asp 
                165                 170                 175     

Ala His Phe Gln Phe Gly Asp Met Asp Ile Gln Leu Tyr Asn Tyr Glu 
            180                 185                 190         

Asn Glu Thr Asp Ser Ser Gly Glu Leu Lys Lys Ile Trp Asp Asp Asn 
        195                 200                 205             

Ser Asn Ser Leu Ile Ser Val Val Lys Val Asn Gly Lys Lys Ile Tyr 
    210                 215                 220                 

Leu Gly Gly Asp Leu Asp Asn Val His Gly Ala Glu Asp Lys Tyr Gly 
225                 230                 235                 240 

Pro Leu Ile Gly Lys Val Asp Leu Met Lys Phe Asn His His His Asp 
                245                 250                 255     

Thr Asn Lys Ser Asn Thr Lys Asp Phe Ile Lys Asn Leu Ser Pro Ser 
            260                 265                 270         

Leu Ile Val Gln Thr Ser Asp Ser Leu Pro Trp Lys Asn Gly Val Asp 
        275                 280                 285             

Ser Glu Tyr Val Asn Trp Leu Lys Glu Arg Gly Ile Glu Arg Ile Asn 
    290                 295                 300                 

Ala Ala Ser Lys Asp Tyr Asp Ala Thr Val Phe Asp Ile Arg Lys Asp 
305                 310                 315                 320 

Gly Phe Val Asn Ile Ser Thr Ser Tyr Lys Pro Ile Pro Ser Phe Gln 
                325                 330                 335     

Ala Gly Trp His Lys Ser Ala Tyr Gly Asn Trp Trp Tyr Gln Ala Pro 
            340                 345                 350         

Asp Ser Thr Gly Glu Tyr Ala Val Gly Trp Asn Glu Ile Glu Gly Glu 
        355                 360                 365             

Trp Tyr Tyr Phe Asn Gln Thr Gly Ile Leu Leu Gln Asn Gln Trp Lys 
    370                 375                 380                 

Lys Trp Asn Asn His Trp Phe Tyr Leu Thr Asp Ser Gly Ala Ser Ala 
385                 390                 395                 400 

Lys Asn Trp Lys Lys Ile Ala Gly Ile Trp Tyr Tyr Phe Asn Lys Glu 
                405                 410                 415     

Asn Gln Met Glu Ile Gly Trp Ile Gln Asp Lys Glu Gln Trp Tyr Tyr 
            420                 425                 430         

Leu Asp Val Asp Gly Ser Met Lys Thr Gly Trp Leu Gln Tyr Met Gly 
        435                 440                 445             

Gln Trp Tyr Tyr Phe Ala Pro Ser Gly Glu Met Lys Met Gly Trp Val 
    450                 455                 460                 

Lys Asp Lys Glu Thr Trp Tyr Tyr Met Asp Ser Thr Gly Val Met Lys 
465                 470                 475                 480 

Thr Gly Glu Ile Glu Val Ala Gly Gln His Tyr Tyr Leu Glu Asp Ser 
                485                 490                 495     

Gly Ala Met Lys Gln Gly Trp His Lys Lys Ala Asn Asp Trp Tyr Phe 
            500                 505                 510         

Tyr Lys Thr Asp Gly Ser Arg Ala Val Gly Trp Ile Lys Asp Lys Asp 
        515                 520                 525             

Lys Trp Tyr Phe Leu Lys Glu Asn Gly Gln Leu Leu Val Asn Gly Lys 
    530                 535                 540                 

Thr Pro Glu Gly Tyr Thr Val Asp Ser Ser Gly Ala Trp Leu Val Asp 
545                 550                 555                 560 

Val Ser Ile Glu Lys Ser Ala Thr Ile Lys Thr Thr Ser His Ser Glu 
                565                 570                 575     

Ile Lys Glu Ser Lys Glu Val Val Lys Lys Asp Leu Glu Asn Lys Glu 
            580                 585                 590         

Thr Ser Gln His Glu Ser Val Thr Asn Phe Ser Thr Ser Gln Asp Leu 
        595                 600                 605             

Thr Ser Ser Thr Ser Gln Ser Ser Glu Thr Ser Val Asn Lys Ser Glu 
    610                 615                 620                 

Ser Glu Gln 
625         

<210>   1817
<211>   1107
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1817
atgaaataca aacggattgt ctttaaggtg ggtacttctt ctctgacaaa tgaggatgga   60
agtttatcac gtagtaaggt aaaggatatt acccagcagt tggctatgct gcacgaggct   120
ggtcatgagt tgattttggt gtcttcaggt gccattgcgg ctggttttgg agccttagga   180
tttaaaaagc gtccgactaa gattgctgat aaacaggctt cagcagcggt agggcagggg   240
cttttgttgg aagaatatac aaccaatctt ctcttgcgtc aaatcgtttc tgcacaaatc   300
ttgctgaccc aagatgactt tgtggataag cgtcgttata aaaatgccca tcaggctttg   360
tcggttttgc tcaaccgtgg ggcaattcct atcatcaatg agaatgatag tgtcgttatt   420
gatgagctca aggttgggga caatgacact ctaagtgctc aagtagcggc gatggtccaa   480
gcagaccttt tagttttctt gacagatgtg gacggtctct atactggaaa tcctaattca   540
gatccaagag ccaaacgctt ggagagaatc gagaccatca atcgtgagat tattgatatg   600
gctggtggag ctggttcgtc aaacggaact gggggtatgt taaccaaaat caaggctgca   660
actatcgcga cggaatcagg agttcctgtt tatatctgct catccttgaa atcagattcc   720
atgattgagg cggcagagga gaccgaggat ggttcttact ttgttgctca agagaagggg   780
cttcgtaccc agaaacaatg gcttgccttc tatgctcaga gtcaaggttc tatttgggtt   840
gataaagggg ctgcggaagc tctctctcaa tatggaaaga gtcttctctt atctggtatc   900
gttgaagcag aaggagtctt ttcttacggt gatatcgtga cagtatttga caaggaaagt   960
ggaaaatcac ttggaaaagg acgcgtgcaa tttggagcat ctgctttgga ggatatgttg   1020
cgttctcaaa aagccaaggg tgtcttgatt taccgtgacg actggatttc cattactcct   1080
gaaatccaac tactttttac agaattt                                       1107

<210>   1818
<211>   369
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamate 5-kinase (proB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902876 (0.E+01)

<400>   1818
Met Lys Tyr Lys Arg Ile Val Phe Lys Val Gly Thr Ser Ser Leu Thr 
1               5                   10                  15      

Asn Glu Asp Gly Ser Leu Ser Arg Ser Lys Val Lys Asp Ile Thr Gln 
            20                  25                  30          

Gln Leu Ala Met Leu His Glu Ala Gly His Glu Leu Ile Leu Val Ser 
        35                  40                  45              

Ser Gly Ala Ile Ala Ala Gly Phe Gly Ala Leu Gly Phe Lys Lys Arg 
    50                  55                  60                  

Pro Thr Lys Ile Ala Asp Lys Gln Ala Ser Ala Ala Val Gly Gln Gly 
65                  70                  75                  80  

Leu Leu Leu Glu Glu Tyr Thr Thr Asn Leu Leu Leu Arg Gln Ile Val 
                85                  90                  95      

Ser Ala Gln Ile Leu Leu Thr Gln Asp Asp Phe Val Asp Lys Arg Arg 
            100                 105                 110         

Tyr Lys Asn Ala His Gln Ala Leu Ser Val Leu Leu Asn Arg Gly Ala 
        115                 120                 125             

Ile Pro Ile Ile Asn Glu Asn Asp Ser Val Val Ile Asp Glu Leu Lys 
    130                 135                 140                 

Val Gly Asp Asn Asp Thr Leu Ser Ala Gln Val Ala Ala Met Val Gln 
145                 150                 155                 160 

Ala Asp Leu Leu Val Phe Leu Thr Asp Val Asp Gly Leu Tyr Thr Gly 
                165                 170                 175     

Asn Pro Asn Ser Asp Pro Arg Ala Lys Arg Leu Glu Arg Ile Glu Thr 
            180                 185                 190         

Ile Asn Arg Glu Ile Ile Asp Met Ala Gly Gly Ala Gly Ser Ser Asn 
        195                 200                 205             

Gly Thr Gly Gly Met Leu Thr Lys Ile Lys Ala Ala Thr Ile Ala Thr 
    210                 215                 220                 

Glu Ser Gly Val Pro Val Tyr Ile Cys Ser Ser Leu Lys Ser Asp Ser 
225                 230                 235                 240 

Met Ile Glu Ala Ala Glu Glu Thr Glu Asp Gly Ser Tyr Phe Val Ala 
                245                 250                 255     

Gln Glu Lys Gly Leu Arg Thr Gln Lys Gln Trp Leu Ala Phe Tyr Ala 
            260                 265                 270         

Gln Ser Gln Gly Ser Ile Trp Val Asp Lys Gly Ala Ala Glu Ala Leu 
        275                 280                 285             

Ser Gln Tyr Gly Lys Ser Leu Leu Leu Ser Gly Ile Val Glu Ala Glu 
    290                 295                 300                 

Gly Val Phe Ser Tyr Gly Asp Ile Val Thr Val Phe Asp Lys Glu Ser 
305                 310                 315                 320 

Gly Lys Ser Leu Gly Lys Gly Arg Val Gln Phe Gly Ala Ser Ala Leu 
                325                 330                 335     

Glu Asp Met Leu Arg Ser Gln Lys Ala Lys Gly Val Leu Ile Tyr Arg 
            340                 345                 350         

Asp Asp Trp Ile Ser Ile Thr Pro Glu Ile Gln Leu Leu Phe Thr Glu 
        355                 360                 365             

Phe 
    

<210>   1819
<211>   1260
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1819
atggtgagta gacaagaaca atttgaacag gtacaggctg ttaaaaaatc gattaacaca   60
gctagtgaag aagtgaaaaa ccaagccttg ctagccatgg ctgatcactt agtggctgct   120
actgaggaaa ttttagcggc taatgccctc gatatggcag cggctaaggg gaaaatctca   180
gatgtgatgt tggatcgtct ttatttggat gcagatcgta tagaagcgat ggcaagagga   240
attcgtgaag tggttgcctt accagatcca atcggtgaag ttttagaaac aagtcagctt   300
gaaaatggtt tggttatcac aaaaaaacgt gtagctatgg gtgtcatcgg tattatctat   360
gaaagccgtc caaatgtgac gtctgatgcg gctgctttga ctcttaagag tggaaatgcg   420
gttgttcttc gtagtggtaa ggatgcctat caaacaaccc atgccattgt cacagccttg   480
aagaagggct tggagacgac tactattcat ccaaatgtga ttcaactggt ggaggatact   540
agccgtgaaa gtagttatgc tatgatgaag gccaagggct atctagacct tctcattcct   600
cgtggaggag ctggcttgat caatgcagtg gttgagaatg cgattgtacc tgttatcgag   660
acagggactg ggattgtcca tgtctatgtg gataaggatg cagacgaaga caaggcgctg   720
tctatcatca acaatgctaa aaccagtcgt ccttctgttt gtaatgccat ggaggttctg   780
ctggttcatg aaaacaaggc agcaagcttc cttcctcgct tggagcaagt gttggttgca   840
gagcgtaagg aagctggact ggaaccaatt caattccgcc tagatagcaa agcaagccag   900
tttgtttcag gtcaagcagc tgagacccaa gactttgaca ccgagttttt agactatgtc   960
cttgctgtta aggttgtgag cagtttagaa gaagcggttg cgcacattga atcccacagc   1020
acccatcatt cggatgctat tgtgacggaa aatgctgaag ctgcagcata ctttacagat   1080
caagtggact ctgcagcggt gtatgttaat gcctcaactc gtttcacaga tggaggacaa   1140
tttggtcttg gttgtgaaat ggggatttct actcagaaat tgcacgcgcg tggtcccatg   1200
ggcttgaaag agttgaccag ctacaagtat gtggttgccg gtgatgggca gataagggag   1260

<210>   1820
<211>   420
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   gamma-glutamyl phosphate reductase (proA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902877 (0.E+01)

<400>   1820
Met Val Ser Arg Gln Glu Gln Phe Glu Gln Val Gln Ala Val Lys Lys 
1               5                   10                  15      

Ser Ile Asn Thr Ala Ser Glu Glu Val Lys Asn Gln Ala Leu Leu Ala 
            20                  25                  30          

Met Ala Asp His Leu Val Ala Ala Thr Glu Glu Ile Leu Ala Ala Asn 
        35                  40                  45              

Ala Leu Asp Met Ala Ala Ala Lys Gly Lys Ile Ser Asp Val Met Leu 
    50                  55                  60                  

Asp Arg Leu Tyr Leu Asp Ala Asp Arg Ile Glu Ala Met Ala Arg Gly 
65                  70                  75                  80  

Ile Arg Glu Val Val Ala Leu Pro Asp Pro Ile Gly Glu Val Leu Glu 
                85                  90                  95      

Thr Ser Gln Leu Glu Asn Gly Leu Val Ile Thr Lys Lys Arg Val Ala 
            100                 105                 110         

Met Gly Val Ile Gly Ile Ile Tyr Glu Ser Arg Pro Asn Val Thr Ser 
        115                 120                 125             

Asp Ala Ala Ala Leu Thr Leu Lys Ser Gly Asn Ala Val Val Leu Arg 
    130                 135                 140                 

Ser Gly Lys Asp Ala Tyr Gln Thr Thr His Ala Ile Val Thr Ala Leu 
145                 150                 155                 160 

Lys Lys Gly Leu Glu Thr Thr Thr Ile His Pro Asn Val Ile Gln Leu 
                165                 170                 175     

Val Glu Asp Thr Ser Arg Glu Ser Ser Tyr Ala Met Met Lys Ala Lys 
            180                 185                 190         

Gly Tyr Leu Asp Leu Leu Ile Pro Arg Gly Gly Ala Gly Leu Ile Asn 
        195                 200                 205             

Ala Val Val Glu Asn Ala Ile Val Pro Val Ile Glu Thr Gly Thr Gly 
    210                 215                 220                 

Ile Val His Val Tyr Val Asp Lys Asp Ala Asp Glu Asp Lys Ala Leu 
225                 230                 235                 240 

Ser Ile Ile Asn Asn Ala Lys Thr Ser Arg Pro Ser Val Cys Asn Ala 
                245                 250                 255     

Met Glu Val Leu Leu Val His Glu Asn Lys Ala Ala Ser Phe Leu Pro 
            260                 265                 270         

Arg Leu Glu Gln Val Leu Val Ala Glu Arg Lys Glu Ala Gly Leu Glu 
        275                 280                 285             

Pro Ile Gln Phe Arg Leu Asp Ser Lys Ala Ser Gln Phe Val Ser Gly 
    290                 295                 300                 

Gln Ala Ala Glu Thr Gln Asp Phe Asp Thr Glu Phe Leu Asp Tyr Val 
305                 310                 315                 320 

Leu Ala Val Lys Val Val Ser Ser Leu Glu Glu Ala Val Ala His Ile 
                325                 330                 335     

Glu Ser His Ser Thr His His Ser Asp Ala Ile Val Thr Glu Asn Ala 
            340                 345                 350         

Glu Ala Ala Ala Tyr Phe Thr Asp Gln Val Asp Ser Ala Ala Val Tyr 
        355                 360                 365             

Val Asn Ala Ser Thr Arg Phe Thr Asp Gly Gly Gln Phe Gly Leu Gly 
    370                 375                 380                 

Cys Glu Met Gly Ile Ser Thr Gln Lys Leu His Ala Arg Gly Pro Met 
385                 390                 395                 400 

Gly Leu Lys Glu Leu Thr Ser Tyr Lys Tyr Val Val Ala Gly Asp Gly 
                405                 410                 415     

Gln Ile Arg Glu 
            420 

<210>   1821
<211>   795
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1821
atgaagattg gatttatcgg tttggggaat atgggtgcta gcttggcaaa atctgtcttg   60
cagactagga cgtcagatga gattctcctt gccaatcgta gtcaagctaa ggtagatgct   120
ttcattgcag actttggtgg tcaggcttcc agcaatgaag aaatgtttgc agaagcagat   180
gtgatttttc taggagttaa gcctgctcag ttttctgaac tgctttctca ataccagacc   240
atccttgaaa aaagagaaag tcttcttttg atttcgatgg cagctggatt gaccttagaa   300
aaactagcaa gtcttatccc aagtcaacac cgaattattc gtatgatgcc taatacccct   360
gcttctatcg ggcaaggagt gattagttat gccttgtctc ctaattgcag ggctgaggac   420
agtgagctct tttatcagct tttagccaag gctggtctct tggttgaact aggagaaagt   480
ttaatcgatg cagcgacagg tcttgcaggt tgtggaccag cctttgtcta tctttttatc   540
gaggccttgg cagatgcagg tgttcagaca ggattaccac gagaaatagc attgaaaatg   600
gcagcacaaa ctgtggtagg agctgggcaa ttggtccttg aaagtcagca acatcctgga   660
gtattgaaag accaagtctg tagcccaggc ggttcgacta tcgctggtgt agcaagccta   720
gaagcgcatg ctttccgagg aacagtcatg gatgcagttc atcaagccta caaacgaaca   780
caagaactag gtaaa                                                    795

<210>   1822
<211>   265
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyrroline-5-carboxylate reductase (proC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902878 (e-141)

<400>   1822
Met Lys Ile Gly Phe Ile Gly Leu Gly Asn Met Gly Ala Ser Leu Ala 
1               5                   10                  15      

Lys Ser Val Leu Gln Thr Arg Thr Ser Asp Glu Ile Leu Leu Ala Asn 
            20                  25                  30          

Arg Ser Gln Ala Lys Val Asp Ala Phe Ile Ala Asp Phe Gly Gly Gln 
        35                  40                  45              

Ala Ser Ser Asn Glu Glu Met Phe Ala Glu Ala Asp Val Ile Phe Leu 
    50                  55                  60                  

Gly Val Lys Pro Ala Gln Phe Ser Glu Leu Leu Ser Gln Tyr Gln Thr 
65                  70                  75                  80  

Ile Leu Glu Lys Arg Glu Ser Leu Leu Leu Ile Ser Met Ala Ala Gly 
                85                  90                  95      

Leu Thr Leu Glu Lys Leu Ala Ser Leu Ile Pro Ser Gln His Arg Ile 
            100                 105                 110         

Ile Arg Met Met Pro Asn Thr Pro Ala Ser Ile Gly Gln Gly Val Ile 
        115                 120                 125             

Ser Tyr Ala Leu Ser Pro Asn Cys Arg Ala Glu Asp Ser Glu Leu Phe 
    130                 135                 140                 

Tyr Gln Leu Leu Ala Lys Ala Gly Leu Leu Val Glu Leu Gly Glu Ser 
145                 150                 155                 160 

Leu Ile Asp Ala Ala Thr Gly Leu Ala Gly Cys Gly Pro Ala Phe Val 
                165                 170                 175     

Tyr Leu Phe Ile Glu Ala Leu Ala Asp Ala Gly Val Gln Thr Gly Leu 
            180                 185                 190         

Pro Arg Glu Ile Ala Leu Lys Met Ala Ala Gln Thr Val Val Gly Ala 
        195                 200                 205             

Gly Gln Leu Val Leu Glu Ser Gln Gln His Pro Gly Val Leu Lys Asp 
    210                 215                 220                 

Gln Val Cys Ser Pro Gly Gly Ser Thr Ile Ala Gly Val Ala Ser Leu 
225                 230                 235                 240 

Glu Ala His Ala Phe Arg Gly Thr Val Met Asp Ala Val His Gln Ala 
                245                 250                 255     

Tyr Lys Arg Thr Gln Glu Leu Gly Lys 
            260                 265 

<210>   1823
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1823
ttgactgcct cttttatggt ggctgaaatg agaagacaca aaaagattgt cacaaacccc   60
tatttttttg atagaataga agtagtaaaa aagaaa                             96

<210>   1824
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   1824
Met Thr Ala Ser Phe Met Val Ala Glu Met Arg Arg His Lys Lys Ile 
1               5                   10                  15      

Val Thr Asn Pro Tyr Phe Phe Asp Arg Ile Glu Val Val Lys Lys Lys 
            20                  25                  30          


<210>   1825
<211>   636
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1825
atgtcaaaag gatttttagt ctctcttgag ggaccagagg gagcaggcaa gaccagtgtt   60
ttagaggctc tgctaccaat tttagaggaa aaaggagtag aggtgttgac gacccgtgaa   120
cctggcggag tcttgattgg ggagaagatt cgggaagtga ttttggatcc aagtcatact   180
cagatggatg ctaaaacaga gctacttctc tatattgcca gtcgcagaca gcatttggtg   240
gaaaaagttc ttccagccct tgaagctggc aagttggtca tcatggatcg ttttatcgat   300
agttctgttg cctatcaggg atttggtcgt ggcttagata ttgaagccat tgactggctc   360
aatcagtttg cgacagatgg cctcaaaccc gatttgacac tctattttga catcgaggtg   420
gaagaagggc tggctcgtat tgctgctaat agtgaccgcg aggttaatcg tttggatttg   480
gaagggttgg acttgcataa aaaagttcgt caaggctacc tttctcttct ggataaagag   540
ggaaatcgca ttgtcaagat tgatgctagt ctccctttgg agcaagttgt ggaaactacc   600
aaggctgtct tgtttgacgg aatgggcttg gccaaa                             636

<210>   1826
<211>   212
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thymidylate kinase (tmk)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902879 (e-115)

<400>   1826
Met Ser Lys Gly Phe Leu Val Ser Leu Glu Gly Pro Glu Gly Ala Gly 
1               5                   10                  15      

Lys Thr Ser Val Leu Glu Ala Leu Leu Pro Ile Leu Glu Glu Lys Gly 
            20                  25                  30          

Val Glu Val Leu Thr Thr Arg Glu Pro Gly Gly Val Leu Ile Gly Glu 
        35                  40                  45              

Lys Ile Arg Glu Val Ile Leu Asp Pro Ser His Thr Gln Met Asp Ala 
    50                  55                  60                  

Lys Thr Glu Leu Leu Leu Tyr Ile Ala Ser Arg Arg Gln His Leu Val 
65                  70                  75                  80  

Glu Lys Val Leu Pro Ala Leu Glu Ala Gly Lys Leu Val Ile Met Asp 
                85                  90                  95      

Arg Phe Ile Asp Ser Ser Val Ala Tyr Gln Gly Phe Gly Arg Gly Leu 
            100                 105                 110         

Asp Ile Glu Ala Ile Asp Trp Leu Asn Gln Phe Ala Thr Asp Gly Leu 
        115                 120                 125             

Lys Pro Asp Leu Thr Leu Tyr Phe Asp Ile Glu Val Glu Glu Gly Leu 
    130                 135                 140                 

Ala Arg Ile Ala Ala Asn Ser Asp Arg Glu Val Asn Arg Leu Asp Leu 
145                 150                 155                 160 

Glu Gly Leu Asp Leu His Lys Lys Val Arg Gln Gly Tyr Leu Ser Leu 
                165                 170                 175     

Leu Asp Lys Glu Gly Asn Arg Ile Val Lys Ile Asp Ala Ser Leu Pro 
            180                 185                 190         

Leu Glu Gln Val Val Glu Thr Thr Lys Ala Val Leu Phe Asp Gly Met 
        195                 200                 205             

Gly Leu Ala Lys 
    210         

<210>   1827
<211>   249
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1827
ttgctccaaa gggagactag catcaatctt gacaatgcga tttccctctt tatccagaag   60
agaaaggtag ccttgacgaa cttttttatg caagtccaac ccttccaaat ccaaacgatt   120
aacctcgcgg tcactattag cagcaatacg agccagccct tcttccacct cgatgtcaaa   180
atagagtgtc aaatcgggtt tgaggccatc tgtcgcaaac tgattgagcc agtcaatggc   240
ttcaatatc                                                           249

<210>   1828
<211>   83
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1828
Met Leu Gln Arg Glu Thr Ser Ile Asn Leu Asp Asn Ala Ile Ser Leu 
1               5                   10                  15      

Phe Ile Gln Lys Arg Lys Val Ala Leu Thr Asn Phe Phe Met Gln Val 
            20                  25                  30          

Gln Pro Phe Gln Ile Gln Thr Ile Asn Leu Ala Val Thr Ile Ser Ser 
        35                  40                  45              

Asn Thr Ser Gln Pro Phe Phe His Leu Asp Val Lys Ile Glu Cys Gln 
    50                  55                  60                  

Ile Gly Phe Glu Ala Ile Cys Arg Lys Leu Ile Glu Pro Val Asn Gly 
65                  70                  75                  80  

Phe Asn Ile 
            

<210>   1829
<211>   888
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1829
atgaaacaag atcaactaaa ggcttggcaa ccagctcagt ttgaccgttt tgtccgtatc   60
ttagaacaag accagctcaa tcacgcctat ctcttttcag gtttctttga aagcttggaa   120
atggcgcaat ttttagctaa gagcctcttt tgtacggata aagttggcgt cttaccatgt   180
gagaaatgcc gaagttgcaa gctgattgaa cagggagaat ttcccgatgt caccttgatt   240
aaaccagtta atcaggtcat taagacggaa cgcattcgag aattggtggg tcagttttct   300
caagcaggga ttgaaagcca gcaacaggtc tttatcatcg agcaagcgga taaaatgcat   360
cccaacgcag ccaattctct gctcaaggtc atcgaagaac cccagagtga agtttatatt   420
ttcttcttga ctagcgatga ggaaaagatg ttaccgacaa tccgaagtcg gactcagatc   480
ttccacttta aaaagcaaga agaaaaactt atcttactct tagaacaaat gggacttgtt   540
aagaaaaaag cgactctttt agctaagttt agtcaatcgc gagctgaagc agaaaagttg   600
gctaatcagg caagtttttg gaccttggtc gatgaaagtg aacgcctgct gacttggtta   660
gtagctaaga aaaaagaaag ttatctacag gttgccaaat tagccaactt ggcagatgat   720
aaggaaaaac aggatcaggt tttacggatt cttgaagttc tctgtgggca ggacctcttg   780
caggtaagag taagagtgat tctacaagat ttactagaag ctagaaaaat gtggcaagct   840
aatgtcagct ttcaaaatgc catggaatat ctggtcttga aagaaata                888

<210>   1830
<211>   296
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA polymerase III, delta prime subunit (holB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902880 (e-164)

<400>   1830
Met Lys Gln Asp Gln Leu Lys Ala Trp Gln Pro Ala Gln Phe Asp Arg 
1               5                   10                  15      

Phe Val Arg Ile Leu Glu Gln Asp Gln Leu Asn His Ala Tyr Leu Phe 
            20                  25                  30          

Ser Gly Phe Phe Glu Ser Leu Glu Met Ala Gln Phe Leu Ala Lys Ser 
        35                  40                  45              

Leu Phe Cys Thr Asp Lys Val Gly Val Leu Pro Cys Glu Lys Cys Arg 
    50                  55                  60                  

Ser Cys Lys Leu Ile Glu Gln Gly Glu Phe Pro Asp Val Thr Leu Ile 
65                  70                  75                  80  

Lys Pro Val Asn Gln Val Ile Lys Thr Glu Arg Ile Arg Glu Leu Val 
                85                  90                  95      

Gly Gln Phe Ser Gln Ala Gly Ile Glu Ser Gln Gln Gln Val Phe Ile 
            100                 105                 110         

Ile Glu Gln Ala Asp Lys Met His Pro Asn Ala Ala Asn Ser Leu Leu 
        115                 120                 125             

Lys Val Ile Glu Glu Pro Gln Ser Glu Val Tyr Ile Phe Phe Leu Thr 
    130                 135                 140                 

Ser Asp Glu Glu Lys Met Leu Pro Thr Ile Arg Ser Arg Thr Gln Ile 
145                 150                 155                 160 

Phe His Phe Lys Lys Gln Glu Glu Lys Leu Ile Leu Leu Leu Glu Gln 
                165                 170                 175     

Met Gly Leu Val Lys Lys Lys Ala Thr Leu Leu Ala Lys Phe Ser Gln 
            180                 185                 190         

Ser Arg Ala Glu Ala Glu Lys Leu Ala Asn Gln Ala Ser Phe Trp Thr 
        195                 200                 205             

Leu Val Asp Glu Ser Glu Arg Leu Leu Thr Trp Leu Val Ala Lys Lys 
    210                 215                 220                 

Lys Glu Ser Tyr Leu Gln Val Ala Lys Leu Ala Asn Leu Ala Asp Asp 
225                 230                 235                 240 

Lys Glu Lys Gln Asp Gln Val Leu Arg Ile Leu Glu Val Leu Cys Gly 
                245                 250                 255     

Gln Asp Leu Leu Gln Val Arg Val Arg Val Ile Leu Gln Asp Leu Leu 
            260                 265                 270         

Glu Ala Arg Lys Met Trp Gln Ala Asn Val Ser Phe Gln Asn Ala Met 
        275                 280                 285             

Glu Tyr Leu Val Leu Lys Glu Ile 
    290                 295     

<210>   1831
<211>   315
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1831
atggacaaaa aagaattatt tgacgcgctg gatgattttt cccaacaatt attggtaacc   60
ttagccgatg tggaagccat caagaaaaat ctcaagagcc tggtagagga aaatacagct   120
cttcgcttgg aaaatagtaa gttgcgagaa cgcttgggtg aggtggaagc agatgctcct   180
gtcaaggcca agcatgttcg tgaaagtgtc cgtcgcattt accgtgatgg atttcacgta   240
tgtaatgatt tttatggaca acgtcgagag caggacgagg aatgtatgtt ttgtgacgag   300
ttgctataca gggag                                                    315

<210>   1832
<211>   105
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902881 (4.E-57)

<400>   1832
Met Asp Lys Lys Glu Leu Phe Asp Ala Leu Asp Asp Phe Ser Gln Gln 
1               5                   10                  15      

Leu Leu Val Thr Leu Ala Asp Val Glu Ala Ile Lys Lys Asn Leu Lys 
            20                  25                  30          

Ser Leu Val Glu Glu Asn Thr Ala Leu Arg Leu Glu Asn Ser Lys Leu 
        35                  40                  45              

Arg Glu Arg Leu Gly Glu Val Glu Ala Asp Ala Pro Val Lys Ala Lys 
    50                  55                  60                  

His Val Arg Glu Ser Val Arg Arg Ile Tyr Arg Asp Gly Phe His Val 
65                  70                  75                  80  

Cys Asn Asp Phe Tyr Gly Gln Arg Arg Glu Gln Asp Glu Glu Cys Met 
                85                  90                  95      

Phe Cys Asp Glu Leu Leu Tyr Arg Glu 
            100                 105 

<210>   1833
<211>   867
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1833
atgcagattc aaaaaagttt taaggggcag tctccctatg gcaagctgta tctagtggca   60
acgccgattg gcaatctaga tgatatgact tttcgtgcta tccagacctt gaaagaagtg   120
gactggattg ctgctgagga tacgcgcaat acagggcttt tgctcaagca ttttgacatt   180
tccaccaagc agatcagttt tcatgagcac aatgccaagg aaaaaattcc tgatttgatt   240
ggtttcttga aagcagggca aagtattgct caggtctctg atgccggttt gcctagcatt   300
tcagaccctg gtcatgattt agttaaggca gctattgagg aagaaattgc agttgtgaca   360
gttccaggtg cctctgcagg aatttctgcc ttgattgcca gtggtttagc gccacagcca   420
catatctttt acggtttttt accgagaaaa tcaggtcagc agaagcaatt ttttggcttg   480
aaaaaagatt atcctgaaac acagattttt tatgaatcac ctcatcgtgt agcagacacg   540
ttggaaaata tgttagaagt ctacggtgac cgctccgttg tcttggtcag ggaattgacc   600
aaaatctatg aagaatacca acgaggtact atctctgagt tattagaaag cattgctgaa   660
acgccactca agggcgaatg tcttctcatt gttgagggtg ccagtcaggg tgtggaggaa   720
aaggacgagg aagacttgtt cgtagaaatt caaacccgca tccagcaagg tgtgaagaaa   780
aaccaagcta tcaaggaagt cgctaagatt taccagtgga ataaaagtca gctctacgct   840
gcctaccacg actgggaaga aaaacaa                                       867

<210>   1834
<211>   289
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tetrapyrrole methylase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902882 (e-165)

<400>   1834
Met Gln Ile Gln Lys Ser Phe Lys Gly Gln Ser Pro Tyr Gly Lys Leu 
1               5                   10                  15      

Tyr Leu Val Ala Thr Pro Ile Gly Asn Leu Asp Asp Met Thr Phe Arg 
            20                  25                  30          

Ala Ile Gln Thr Leu Lys Glu Val Asp Trp Ile Ala Ala Glu Asp Thr 
        35                  40                  45              

Arg Asn Thr Gly Leu Leu Leu Lys His Phe Asp Ile Ser Thr Lys Gln 
    50                  55                  60                  

Ile Ser Phe His Glu His Asn Ala Lys Glu Lys Ile Pro Asp Leu Ile 
65                  70                  75                  80  

Gly Phe Leu Lys Ala Gly Gln Ser Ile Ala Gln Val Ser Asp Ala Gly 
                85                  90                  95      

Leu Pro Ser Ile Ser Asp Pro Gly His Asp Leu Val Lys Ala Ala Ile 
            100                 105                 110         

Glu Glu Glu Ile Ala Val Val Thr Val Pro Gly Ala Ser Ala Gly Ile 
        115                 120                 125             

Ser Ala Leu Ile Ala Ser Gly Leu Ala Pro Gln Pro His Ile Phe Tyr 
    130                 135                 140                 

Gly Phe Leu Pro Arg Lys Ser Gly Gln Gln Lys Gln Phe Phe Gly Leu 
145                 150                 155                 160 

Lys Lys Asp Tyr Pro Glu Thr Gln Ile Phe Tyr Glu Ser Pro His Arg 
                165                 170                 175     

Val Ala Asp Thr Leu Glu Asn Met Leu Glu Val Tyr Gly Asp Arg Ser 
            180                 185                 190         

Val Val Leu Val Arg Glu Leu Thr Lys Ile Tyr Glu Glu Tyr Gln Arg 
        195                 200                 205             

Gly Thr Ile Ser Glu Leu Leu Glu Ser Ile Ala Glu Thr Pro Leu Lys 
    210                 215                 220                 

Gly Glu Cys Leu Leu Ile Val Glu Gly Ala Ser Gln Gly Val Glu Glu 
225                 230                 235                 240 

Lys Asp Glu Glu Asp Leu Phe Val Glu Ile Gln Thr Arg Ile Gln Gln 
                245                 250                 255     

Gly Val Lys Lys Asn Gln Ala Ile Lys Glu Val Ala Lys Ile Tyr Gln 
            260                 265                 270         

Trp Asn Lys Ser Gln Leu Tyr Ala Ala Tyr His Asp Trp Glu Glu Lys 
        275                 280                 285             

Gln 
    

<210>   1835
<211>   516
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1835
ttgcgaacat acgaaaataa agaagaacta aaagctgaga tagagaaaac atttgagaaa   60
tatattttag aatttgataa tattccagaa aatttaaaag ataagagagc tgatgaagtt   120
gacagaactc cagcagaaaa ccttgcttat caggttggtt ggaccaactt ggttcttaaa   180
tgggaagaag atgaaagaaa ggggcttcaa gtaaaaacac catcggataa atttaaatgg   240
aatcaacttg gtgaattata tcagtggttc acagatacct acgctcattt atctctgcaa   300
gagttgaaag caaaattaaa tgaaaatatt aattctatct ctgcaatgat tgattcgttg   360
agtgaggaag aattatttga accgcatatg agaaagtggg ctgatgaagc gactaaaaca   420
gcgacttggg aagtgtataa gtttattcat gtaaatacgg ttgcaccttt tggaactttc   480
agaactaaaa tcagaaaatg gaagaagata gtatta                             516

<210>   1836

<211>   172
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902883 (e-100)

<400>   1836
Met Arg Thr Tyr Glu Asn Lys Glu Glu Leu Lys Ala Glu Ile Glu Lys 
1               5                   10                  15      

Thr Phe Glu Lys Tyr Ile Leu Glu Phe Asp Asn Ile Pro Glu Asn Leu 
            20                  25                  30          

Lys Asp Lys Arg Ala Asp Glu Val Asp Arg Thr Pro Ala Glu Asn Leu 
        35                  40                  45              

Ala Tyr Gln Val Gly Trp Thr Asn Leu Val Leu Lys Trp Glu Glu Asp 
    50                  55                  60                  

Glu Arg Lys Gly Leu Gln Val Lys Thr Pro Ser Asp Lys Phe Lys Trp 
65                  70                  75                  80  

Asn Gln Leu Gly Glu Leu Tyr Gln Trp Phe Thr Asp Thr Tyr Ala His 
                85                  90                  95      

Leu Ser Leu Gln Glu Leu Lys Ala Lys Leu Asn Glu Asn Ile Asn Ser 
            100                 105                 110         

Ile Ser Ala Met Ile Asp Ser Leu Ser Glu Glu Glu Leu Phe Glu Pro 
        115                 120                 125             

His Met Arg Lys Trp Ala Asp Glu Ala Thr Lys Thr Ala Thr Trp Glu 
    130                 135                 140                 

Val Tyr Lys Phe Ile His Val Asn Thr Val Ala Pro Phe Gly Thr Phe 
145                 150                 155                 160 

Arg Thr Lys Ile Arg Lys Trp Lys Lys Ile Val Leu 
                165                 170         

<210>   1837
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1837
ttggtaacca tttttatgaa attttttaaa gttaaaaata taatttataa tactatcttc   60
ttccattttc tgattttagt tctgaaagtt ccaaaaggtg caaccgtatt taca         114

<210>   1838
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1838
Met Val Thr Ile Phe Met Lys Phe Phe Lys Val Lys Asn Ile Ile Tyr 
1               5                   10                  15      

Asn Thr Ile Phe Phe His Phe Leu Ile Leu Val Leu Lys Val Pro Lys 
            20                  25                  30          

Gly Ala Thr Val Phe Thr 
        35              

<210>   1839
<211>   282
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1839
atggactttg aatattttta taacagagaa gcggaaagat ttaacttctt aaaagtaccg   60
gagatattag ttgatagaga agaatttcgg ggcttatcag cagaagcaat tatcctttat   120
tccatacttc ttaaacagac aggaatgtca tttaagaata actggataga caaggaaggc   180
agagtattta tctattttac tgtcgaagaa attatgaaaa gaagaaatat ctcaaagcca   240
actgccataa aaacattaga tgagcttgat gtaaaaaagg aa                      282

<210>   1840
<211>   94
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   replication initiator protein, truncation FRAMESHIFT

<400>   1840
Met Asp Phe Glu Tyr Phe Tyr Asn Arg Glu Ala Glu Arg Phe Asn Phe 
1               5                   10                  15      

Leu Lys Val Pro Glu Ile Leu Val Asp Arg Glu Glu Phe Arg Gly Leu 
            20                  25                  30          

Ser Ala Glu Ala Ile Ile Leu Tyr Ser Ile Leu Leu Lys Gln Thr Gly 
        35                  40                  45              

Met Ser Phe Lys Asn Asn Trp Ile Asp Lys Glu Gly Arg Val Phe Ile 
    50                  55                  60                  

Tyr Phe Thr Val Glu Glu Ile Met Lys Arg Arg Asn Ile Ser Lys Pro 
65                  70                  75                  80  

Thr Ala Ile Lys Thr Leu Asp Glu Leu Asp Val Lys Lys Glu 
                85                  90                  

<210>   1841
<211>   297
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1841
atgagtatat ttcaggtaaa agaaaatgac ttacagaagt caaaaaactt aacttcagaa   60
gtaaaagatt ttaacctcag aagtaaagaa aatgaacttc aagaggttaa gaaccttgac   120
tctaactata tagagaataa taagagtaag tatagtaaga gagaatatag ttttggtgaa   180
aacggacttg gaacatttca aaatgtgttt ttagctgctg aagatatatc ggatttacaa   240
atcataatga actcacagct tgagaattac attagacttc ctgcaaaact agaatcc      297

<210>   1842
<211>   99
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1842
Met Ser Ile Phe Gln Val Lys Glu Asn Asp Leu Gln Lys Ser Lys Asn 
1               5                   10                  15      

Leu Thr Ser Glu Val Lys Asp Phe Asn Leu Arg Ser Lys Glu Asn Glu 
            20                  25                  30          

Leu Gln Glu Val Lys Asn Leu Asp Ser Asn Tyr Ile Glu Asn Asn Lys 
        35                  40                  45              

Ser Lys Tyr Ser Lys Arg Glu Tyr Ser Phe Gly Glu Asn Gly Leu Gly 
    50                  55                  60                  

Thr Phe Gln Asn Val Phe Leu Ala Ala Glu Asp Ile Ser Asp Leu Gln 
65                  70                  75                  80  

Ile Ile Met Asn Ser Gln Leu Glu Asn Tyr Ile Arg Leu Pro Ala Lys 
                85                  90                  95      

Leu Glu Ser 
            

<210>   1843
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1843
atgaaggctc aagcgattgt cacaagtcaa gggagaattg tttctttgga tatcgctgtg   60
aactattgtc gtgatatgaa gttgttcaaa atgagtcgca gaaatatcgg acaagctggt   120
aaaatcttgt ctgacagtgg ttatcaaggg ctcatgaaga tatatcctca agtacaaact   180
ccacgtaaat ccagcaaact caagccgcta acagctgaag ataaagcctg taaccatgcg   240
ctatccaagg agagaagcaa gattgagaac atctttgcca aagtaaaaac gtttaaaatg   300
ttttcaacaa tctatcgaaa tcatcgtaaa cgcttcggat tacgaatgaa tttgattgct   360
ggcattatca atcatgaact aggattc                                       387

<210>   1844
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfB FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903038 (3.E-66)

<400>   1844
Met Lys Ala Gln Ala Ile Val Thr Ser Gln Gly Arg Ile Val Ser Leu 

1               5                   10                  15      

Asp Ile Ala Val Asn Tyr Cys Arg Asp Met Lys Leu Phe Lys Met Ser 
            20                  25                  30          

Arg Arg Asn Ile Gly Gln Ala Gly Lys Ile Leu Ser Asp Ser Gly Tyr 
        35                  40                  45              

Gln Gly Leu Met Lys Ile Tyr Pro Gln Val Gln Thr Pro Arg Lys Ser 
    50                  55                  60                  

Ser Lys Leu Lys Pro Leu Thr Ala Glu Asp Lys Ala Cys Asn His Ala 
65                  70                  75                  80  

Leu Ser Lys Glu Arg Ser Lys Ile Glu Asn Ile Phe Ala Lys Val Lys 
                85                  90                  95      

Thr Phe Lys Met Phe Ser Thr Ile Tyr Arg Asn His Arg Lys Arg Phe 
            100                 105                 110         

Gly Leu Arg Met Asn Leu Ile Ala Gly Ile Ile Asn His Glu Leu Gly 
        115                 120                 125             

Phe 
    

<210>   1845
<211>   396
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1845
atgaatgatg aagcaagtaa acaactaact gatgcacgat ttaagcgtct tgttggtgtt   60
cagcgcacga cttttgaaga gatattagct gtattaaaaa cagcttatca acttaaacac   120
gcaaaaggtg gacgaaaacc taaattaagc ctagaagacc ttcttatggc cactcttcaa   180
tatgtgcgag aatatcgaac ttatgaacaa attgcggctg attttggtat tcacgaaagc   240
aacttaatcc gtcggagcca atgggttgaa gtaactcttg ttcaaagtgg tgttacgatt   300
tcaagaactc ctctcagttc tgaggacacg gtaatgattg atgcgacgga agtaaaaatc   360
aatcgcccta aaaaaagaat tagcgaatca ttctgg                             396

<210>   1846
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902886 (4.E-67)

<400>   1846
Met Asn Asp Glu Ala Ser Lys Gln Leu Thr Asp Ala Arg Phe Lys Arg 
1               5                   10                  15      

Leu Val Gly Val Gln Arg Thr Thr Phe Glu Glu Ile Leu Ala Val Leu 
            20                  25                  30          

Lys Thr Ala Tyr Gln Leu Lys His Ala Lys Gly Gly Arg Lys Pro Lys 
        35                  40                  45              

Leu Ser Leu Glu Asp Leu Leu Met Ala Thr Leu Gln Tyr Val Arg Glu 
    50                  55                  60                  

Tyr Arg Thr Tyr Glu Gln Ile Ala Ala Asp Phe Gly Ile His Glu Ser 
65                  70                  75                  80  

Asn Leu Ile Arg Arg Ser Gln Trp Val Glu Val Thr Leu Val Gln Ser 
                85                  90                  95      

Gly Val Thr Ile Ser Arg Thr Pro Leu Ser Ser Glu Asp Thr Val Met 
            100                 105                 110         

Ile Asp Ala Thr Glu Val Lys Ile Asn Arg Pro Lys Lys Arg Ile Ser 
        115                 120                 125             

Glu Ser Phe Trp 
    130         

<210>   1847
<211>   270
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1847
ttgtttactt gcttcatcat tcatagaact actataccat attttgtttc gcaggaagtc   60
tattggaaag taagaaatat tgaagctgag gctattagaa gaaattgtga gcgtggtgct   120
attttttcag gtaaaataaa atatcacgaa gattcacagt ttaaaggaga tcactatgtt   180
gaatgttatg ctgttttaga taatacggtt atagcaagag atagaataac agtccctatc   240
gatccgttat gtggaaaaga ttttatagag                                    270

<210>   1848
<211>   90
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein, fusion

<400>   1848
Met Phe Thr Cys Phe Ile Ile His Arg Thr Thr Ile Pro Tyr Phe Val 
1               5                   10                  15      

Ser Gln Glu Val Tyr Trp Lys Val Arg Asn Ile Glu Ala Glu Ala Ile 
            20                  25                  30          

Arg Arg Asn Cys Glu Arg Gly Ala Ile Phe Ser Gly Lys Ile Lys Tyr 
        35                  40                  45              

His Glu Asp Ser Gln Phe Lys Gly Asp His Tyr Val Glu Cys Tyr Ala 
    50                  55                  60                  

Val Leu Asp Asn Thr Val Ile Ala Arg Asp Arg Ile Thr Val Pro Ile 
65                  70                  75                  80  

Asp Pro Leu Cys Gly Lys Asp Phe Ile Glu 
                85                  90  

<210>   1849
<211>   1404
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1849
ttgtgggtgt caaacagccc agtggggtgt tttaatatgg acttaggtcc cacccaaaga   60
ggtattagtg tcgtgtctca atcttatatc aatgttatcg gtgctggttt ggcaggttct   120
gaagcagctt accaaatcgc agagcgtggt attccagtta aactatatga aatgcgtggt   180
gtcaagtcta caccccagca taaaacagac aattttgctg agttggtttg ttccaattct   240
ttgcgtgggg atgctttgac aaatgcagtt ggtcttctca aggaagaaat gcgtcgcttg   300
ggttctgtta tcttggaatc tgctgaggct acacgtgttc ctgcaggtgg tgcccttgca   360
gtggaccgtg atggtttctc tcaaatggtg accgaaaaag ttgccaacca ccccttgatt   420
gaagtggttc gtgatgaaat tacagaattg ccgacagatg ttattacggt tatcgctact   480
ggtcctttga caagtgatgc cttggctgaa aagattcatg ctcttaatga cggtgctggt   540
ttttatttct acgatgcggc agcgcctatt atcgatgtca acactatcga tatgagcaag   600
gtctacctca aatcacgtta tgataaggga gaagcggcct acctcaatgc ccctatgacc   660
aagcaagaat ttatggattt ccatgaagct ttggtcaatg cagaagaagc accgcttagt   720
tcttttgaaa aagaaaagta ctttgaagga tgtatgccta tcgaagtcat ggccaaacgt   780
ggcattaaaa ctatgcttta tggccctatg aagccagtcg gtcttgagta cccagacgac   840
tatacaggac ctcgtgatgg agaatttaaa acaccttatg cggttgtgca acttcgtcag   900
gataatgcag ctggtagcct ctacaatatt gttggtttcc agacccacct caaatgggga   960
gaacaaaagc gtgtcttcca aatgattccg ggtcttgaaa atgcggagtt tgtccgttat   1020
ggtgtgatgc atcgcaattc ttacatggat tcaccaaatc ttcttgagca gacttaccgt   1080
tctaagaaac aaccaaatct cttctttgct ggtcaaatga cgggtgtgga aggctatgtt   1140
gagtcggcgg cttcaggctt agttgcggga attaacgcag ctcgtctctt caaggaagaa   1200
agcgaggcta ttttccccga gacgacagcg attggaagct tagctcatta cattacccat   1260
gccgacagca aacatttcca accaatgaat gtcaattttg ggatcatcaa ggagttggaa   1320
ggcgagcgta tccgtgataa gaaggctcgt tatgaaaaaa ttgcagagcg tgcccttgcc   1380
gacttagagg aatttttgac tgtc                                          1404

<210>   1850
<211>   468
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Gid protein (gid)
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15902888 (0.E+01)

<400>   1850
Met Trp Val Ser Asn Ser Pro Val Gly Cys Phe Asn Met Asp Leu Gly 
1               5                   10                  15      

Pro Thr Gln Arg Gly Ile Ser Val Val Ser Gln Ser Tyr Ile Asn Val 
            20                  25                  30          

Ile Gly Ala Gly Leu Ala Gly Ser Glu Ala Ala Tyr Gln Ile Ala Glu 
        35                  40                  45              

Arg Gly Ile Pro Val Lys Leu Tyr Glu Met Arg Gly Val Lys Ser Thr 
    50                  55                  60                  

Pro Gln His Lys Thr Asp Asn Phe Ala Glu Leu Val Cys Ser Asn Ser 
65                  70                  75                  80  

Leu Arg Gly Asp Ala Leu Thr Asn Ala Val Gly Leu Leu Lys Glu Glu 
                85                  90                  95      

Met Arg Arg Leu Gly Ser Val Ile Leu Glu Ser Ala Glu Ala Thr Arg 
            100                 105                 110         

Val Pro Ala Gly Gly Ala Leu Ala Val Asp Arg Asp Gly Phe Ser Gln 
        115                 120                 125             

Met Val Thr Glu Lys Val Ala Asn His Pro Leu Ile Glu Val Val Arg 
    130                 135                 140                 

Asp Glu Ile Thr Glu Leu Pro Thr Asp Val Ile Thr Val Ile Ala Thr 
145                 150                 155                 160 

Gly Pro Leu Thr Ser Asp Ala Leu Ala Glu Lys Ile His Ala Leu Asn 
                165                 170                 175     

Asp Gly Ala Gly Phe Tyr Phe Tyr Asp Ala Ala Ala Pro Ile Ile Asp 
            180                 185                 190         

Val Asn Thr Ile Asp Met Ser Lys Val Tyr Leu Lys Ser Arg Tyr Asp 
        195                 200                 205             

Lys Gly Glu Ala Ala Tyr Leu Asn Ala Pro Met Thr Lys Gln Glu Phe 
    210                 215                 220                 

Met Asp Phe His Glu Ala Leu Val Asn Ala Glu Glu Ala Pro Leu Ser 
225                 230                 235                 240 

Ser Phe Glu Lys Glu Lys Tyr Phe Glu Gly Cys Met Pro Ile Glu Val 
                245                 250                 255     

Met Ala Lys Arg Gly Ile Lys Thr Met Leu Tyr Gly Pro Met Lys Pro 
            260                 265                 270         

Val Gly Leu Glu Tyr Pro Asp Asp Tyr Thr Gly Pro Arg Asp Gly Glu 
        275                 280                 285             

Phe Lys Thr Pro Tyr Ala Val Val Gln Leu Arg Gln Asp Asn Ala Ala 
    290                 295                 300                 

Gly Ser Leu Tyr Asn Ile Val Gly Phe Gln Thr His Leu Lys Trp Gly 
305                 310                 315                 320 

Glu Gln Lys Arg Val Phe Gln Met Ile Pro Gly Leu Glu Asn Ala Glu 
                325                 330                 335     

Phe Val Arg Tyr Gly Val Met His Arg Asn Ser Tyr Met Asp Ser Pro 
            340                 345                 350         

Asn Leu Leu Glu Gln Thr Tyr Arg Ser Lys Lys Gln Pro Asn Leu Phe 

        355                 360                 365             

Phe Ala Gly Gln Met Thr Gly Val Glu Gly Tyr Val Glu Ser Ala Ala 
    370                 375                 380                 

Ser Gly Leu Val Ala Gly Ile Asn Ala Ala Arg Leu Phe Lys Glu Glu 
385                 390                 395                 400 

Ser Glu Ala Ile Phe Pro Glu Thr Thr Ala Ile Gly Ser Leu Ala His 
                405                 410                 415     

Tyr Ile Thr His Ala Asp Ser Lys His Phe Gln Pro Met Asn Val Asn 
            420                 425                 430         

Phe Gly Ile Ile Lys Glu Leu Glu Gly Glu Arg Ile Arg Asp Lys Lys 
        435                 440                 445             

Ala Arg Tyr Glu Lys Ile Ala Glu Arg Ala Leu Ala Asp Leu Glu Glu 
    450                 455                 460                 

Phe Leu Thr Val 
465             

<210>   1851
<211>   741
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1851
gtgaaaatgg cgaatcccaa gtataaacgt attttaatca agttatcagg tgaagccctt   60
gccggtgaac gtggcgtagg gattgatatc caaacagttc aaacaatcgc aaaagagatt   120
caagaagttc atagcttagg tatcgaaatt gcccttgtta tcggtggagg aaatctctgg   180
cgtggagaac ctgcagcaga agcaggtatg gaccgtgttc aggcagatta cacaggaatg   240
cttgggactg ttatgaatgc tcttgtgatg gcagattcat tgcaacaagt tggggttgat   300
acgcgtgtac aaacagctat tgccatgcaa caagtggcag agccttatgt ccgtggacgt   360
gcccttcgtc accttgaaaa aggccgtatc gttatctttg gtgctggaat tggttcacct   420
tacttctcga cagatacaac agcggccctt cgtgcagctg aaatcgaagc agatgccatc   480
ctcatggcta aaaatggtgt cgatggtgtt tacaatgccg atcctaagaa agataagaca   540
gctgttaagt ttgaagaatt gacccaccgt gacgttatca ataaaggtct tcgtatcatg   600
gactcaacag cttcaaccct ctcaatggac aacgacattg acttggttgt attcaacatg   660
aaccaaccag gcaacatcaa acgtgtcgta tttggtgaaa atatcggaac aacagtttca   720
aataatatcg aagaaaagga a                                             741

<210>   1852
<211>   247
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   uridylate kinase (pyrH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902889 (e-136)

<400>   1852
Met Lys Met Ala Asn Pro Lys Tyr Lys Arg Ile Leu Ile Lys Leu Ser 
1               5                   10                  15      

Gly Glu Ala Leu Ala Gly Glu Arg Gly Val Gly Ile Asp Ile Gln Thr 
            20                  25                  30          

Val Gln Thr Ile Ala Lys Glu Ile Gln Glu Val His Ser Leu Gly Ile 
        35                  40                  45              

Glu Ile Ala Leu Val Ile Gly Gly Gly Asn Leu Trp Arg Gly Glu Pro 
    50                  55                  60                  

Ala Ala Glu Ala Gly Met Asp Arg Val Gln Ala Asp Tyr Thr Gly Met 
65                  70                  75                  80  

Leu Gly Thr Val Met Asn Ala Leu Val Met Ala Asp Ser Leu Gln Gln 
                85                  90                  95      

Val Gly Val Asp Thr Arg Val Gln Thr Ala Ile Ala Met Gln Gln Val 
            100                 105                 110         

Ala Glu Pro Tyr Val Arg Gly Arg Ala Leu Arg His Leu Glu Lys Gly 
        115                 120                 125             

Arg Ile Val Ile Phe Gly Ala Gly Ile Gly Ser Pro Tyr Phe Ser Thr 
    130                 135                 140                 

Asp Thr Thr Ala Ala Leu Arg Ala Ala Glu Ile Glu Ala Asp Ala Ile 
145                 150                 155                 160 

Leu Met Ala Lys Asn Gly Val Asp Gly Val Tyr Asn Ala Asp Pro Lys 
                165                 170                 175     

Lys Asp Lys Thr Ala Val Lys Phe Glu Glu Leu Thr His Arg Asp Val 
            180                 185                 190         

Ile Asn Lys Gly Leu Arg Ile Met Asp Ser Thr Ala Ser Thr Leu Ser 
        195                 200                 205             

Met Asp Asn Asp Ile Asp Leu Val Val Phe Asn Met Asn Gln Pro Gly 
    210                 215                 220                 

Asn Ile Lys Arg Val Val Phe Gly Glu Asn Ile Gly Thr Thr Val Ser 
225                 230                 235                 240 

Asn Asn Ile Glu Glu Lys Glu 
                245         

<210>   1853
<211>   555
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1853
atggctaacg caattattga aaaagctaaa gagagaatga cccagtctca ccaatcactt   60
gctcgtgaat ttggtggtat ccgtgctggt cgtgccaatg caagcttgct tgaccgtgta   120
catgtagaat actatggagt cgaaactcct cttaaccaaa tcgcttcaat tacgattcca   180
gaagcgcgtg ttttgttggt aacaccattt gacaagtctt cattgaaaga catcgaacgt   240
gccttgaacg cttctgatat tggtatcaca ccggctaatg acggttctgt gattcgcttg   300

gttatcccag ctcttacaga agaaactcgt cgtgaccttg ctaaagaagt gaagaaggtc   360
ggcgaaaatg ctaaagtggc tgtccgcaat atccgtcgcg atgctatgga cgaagctaag   420
aaacgagaaa aagcaaaaga aatcactgaa gacgaattga agactcttga aaaagacatt   480
caaaaagtaa cagacgatgc tgttaaacac atcgacgaca tgactgctaa caaagagaaa   540
gaacttttgg aagtc                                                    555

<210>   1854
<211>   185
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosome recycling factor (frr)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902890 (8.E-98)

<400>   1854
Met Ala Asn Ala Ile Ile Glu Lys Ala Lys Glu Arg Met Thr Gln Ser 
1               5                   10                  15      

His Gln Ser Leu Ala Arg Glu Phe Gly Gly Ile Arg Ala Gly Arg Ala 
            20                  25                  30          

Asn Ala Ser Leu Leu Asp Arg Val His Val Glu Tyr Tyr Gly Val Glu 
        35                  40                  45              

Thr Pro Leu Asn Gln Ile Ala Ser Ile Thr Ile Pro Glu Ala Arg Val 
    50                  55                  60                  

Leu Leu Val Thr Pro Phe Asp Lys Ser Ser Leu Lys Asp Ile Glu Arg 
65                  70                  75                  80  

Ala Leu Asn Ala Ser Asp Ile Gly Ile Thr Pro Ala Asn Asp Gly Ser 
                85                  90                  95      

Val Ile Arg Leu Val Ile Pro Ala Leu Thr Glu Glu Thr Arg Arg Asp 
            100                 105                 110         

Leu Ala Lys Glu Val Lys Lys Val Gly Glu Asn Ala Lys Val Ala Val 
        115                 120                 125             

Arg Asn Ile Arg Arg Asp Ala Met Asp Glu Ala Lys Lys Arg Glu Lys 
    130                 135                 140                 

Ala Lys Glu Ile Thr Glu Asp Glu Leu Lys Thr Leu Glu Lys Asp Ile 
145                 150                 155                 160 

Gln Lys Val Thr Asp Asp Ala Val Lys His Ile Asp Asp Met Thr Ala 
                165                 170                 175     

Asn Lys Glu Lys Glu Leu Leu Glu Val 
            180                 185 

<210>   1855
<211>   852
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1855
atgaatacaa atcttgcaag ttttatcgtt ggactgatca tcgatgaaaa cgaccgtttt   60
tactttgtgc aaaaggatgg tcaaacctat gctcttgcta aggaagaagg ccaacataca   120
gtaggggata cggtcaaagg ttttgcatac acggatatga agcaaaaact ccgcctgaca   180
accttagaag tgactgccac tcaggaccaa tttggttggg gacgtgtcac agaggttcgt   240
aaggacttgg gtgtctttgt ggatacaggc cttcctgaca aggaaatcgt tgtgtcactc   300
gatattctcc ctgagctcaa ggaactctgg cctaagaagg gcgaccaact ctacatccgt   360
cttgaagtgg ataagaaaga ccgtatctgg ggcctcttgg cttatcaaga agacttccaa   420
cgtcttgctc gtcctgccta caacaacatg cagaaccaaa actggccagc cattgtttac   480
cgtctcaagc tgtcaggaac ttttgtttac ctaccagaaa ataatatgct tggttttatt   540
catcctagcg agcgttacgc agagccacgt ttggggcaag tattagatgc gcgcgttatt   600
ggtttccgtg aagtggaccg cactctgaac ctctccctca aaccacgctc ctttgaaatg   660
ttggaaaacg atgctcagat gattttgact tatttggaaa gcaatggcgg tttcatgacc   720
ttaaatgaca agtcatctcc agacgacatc aaggcaacct ttggcatttc taaaggtcag   780
ttcaagaaag ctttaggtgg tcttatgaag gctggtaaaa tcaagcagga ccagtttggg   840
acagagttga tt                                                       852

<210>   1856
<211>   284
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902891 (e-164)

<400>   1856
Met Asn Thr Asn Leu Ala Ser Phe Ile Val Gly Leu Ile Ile Asp Glu 
1               5                   10                  15      

Asn Asp Arg Phe Tyr Phe Val Gln Lys Asp Gly Gln Thr Tyr Ala Leu 

            20                  25                  30          

Ala Lys Glu Glu Gly Gln His Thr Val Gly Asp Thr Val Lys Gly Phe 
        35                  40                  45              

Ala Tyr Thr Asp Met Lys Gln Lys Leu Arg Leu Thr Thr Leu Glu Val 
    50                  55                  60                  

Thr Ala Thr Gln Asp Gln Phe Gly Trp Gly Arg Val Thr Glu Val Arg 
65                  70                  75                  80  

Lys Asp Leu Gly Val Phe Val Asp Thr Gly Leu Pro Asp Lys Glu Ile 
                85                  90                  95      

Val Val Ser Leu Asp Ile Leu Pro Glu Leu Lys Glu Leu Trp Pro Lys 
            100                 105                 110         

Lys Gly Asp Gln Leu Tyr Ile Arg Leu Glu Val Asp Lys Lys Asp Arg 
        115                 120                 125             

Ile Trp Gly Leu Leu Ala Tyr Gln Glu Asp Phe Gln Arg Leu Ala Arg 
    130                 135                 140                 

Pro Ala Tyr Asn Asn Met Gln Asn Gln Asn Trp Pro Ala Ile Val Tyr 
145                 150                 155                 160 

Arg Leu Lys Leu Ser Gly Thr Phe Val Tyr Leu Pro Glu Asn Asn Met 
                165                 170                 175     

Leu Gly Phe Ile His Pro Ser Glu Arg Tyr Ala Glu Pro Arg Leu Gly 
            180                 185                 190         

Gln Val Leu Asp Ala Arg Val Ile Gly Phe Arg Glu Val Asp Arg Thr 
        195                 200                 205             

Leu Asn Leu Ser Leu Lys Pro Arg Ser Phe Glu Met Leu Glu Asn Asp 
    210                 215                 220                 

Ala Gln Met Ile Leu Thr Tyr Leu Glu Ser Asn Gly Gly Phe Met Thr 
225                 230                 235                 240 

Leu Asn Asp Lys Ser Ser Pro Asp Asp Ile Lys Ala Thr Phe Gly Ile 
                245                 250                 255     

Ser Lys Gly Gln Phe Lys Lys Ala Leu Gly Gly Leu Met Lys Ala Gly 
            260                 265                 270         

Lys Ile Lys Gln Asp Gln Phe Gly Thr Glu Leu Ile 
        275                 280                 

<210>   1857
<211>   213
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1857
atgagaaaat cattttacac ttggctcatg accgagcgca atcctaaaag taacagtccc   60
aaagcaattt tggcagacct cgcttttgaa gagtcagcct ttccaaaaca cacagatgat   120
tttgatgagg tcagtcgctt tttggaggag catgccagtt tctcttttaa cctaggagat   180
tttgacagca tttggcagga atatctagaa cac                                213

<210>   1858
<211>   71
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902892 (9.E-39)

<400>   1858
Met Arg Lys Ser Phe Tyr Thr Trp Leu Met Thr Glu Arg Asn Pro Lys 
1               5                   10                  15      

Ser Asn Ser Pro Lys Ala Ile Leu Ala Asp Leu Ala Phe Glu Glu Ser 
            20                  25                  30          

Ala Phe Pro Lys His Thr Asp Asp Phe Asp Glu Val Ser Arg Phe Leu 
        35                  40                  45              

Glu Glu His Ala Ser Phe Ser Phe Asn Leu Gly Asp Phe Asp Ser Ile 
    50                  55                  60                  

Trp Gln Glu Tyr Leu Glu His 
65                  70      

<210>   1859
<211>   966
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1859
ttgaaggaac attcaataga cattcaactg agtcatccag atgacctgtt tcatcttttt   60
ggttccaatg aacgccatct tcgtttgatg gaagaagagc ttgatgttgt gattcatgct   120
cgtacggaga ttgtccaggt tttgggagaa gagtctgcct gtgaggaagc ccgtcaagtt   180
attcaggctt tgatggtctt ggtaaatcgt gggatgaccg ttggtacgcc agatgtagtc   240
actgcgatta gcatggtcaa aaatgatgaa attgacaagt ttgtcgccct ttacgaagaa   300
gaaattatca aggataatac tgggaaacct atccgtgtca aaaccctagg gcaaaagctt   360
tatgtggaca gtgtcaaaca gcatgatgtg acctttggaa ttgggccagc aggtacaggg   420
aagaccttcc ttgcagtgac cttggcagtg actgccctta aacgtgggca agtcaagcga   480
attatcctaa ctcgtccagc ggtggaagcg ggagagagtc ttggatttct tccgggtgat   540
cttaaggaga aggtggatcc ttaccttcgt cctgtttacg atgccttgta tcaaattctt   600
gggaaagacc aaacgactcg tctcatggag cgtgaaatta tcgaaattgc gccccttgcc   660
tatatgcgtg gccggacctt ggatgatgcc tttgtcattc tcgatgaggc gcaaaacacg   720
accatcatgc agatgaagat gttcttgacg cgtttaggtt ttcattctaa gatgattgtc   780
aatggagata ttagtcagat tgacctgcca cgtaatgtca agtccggttt gattgatgct   840
caagagaaac tcaagaacat ccatcagatt gactttgttc atttttcagc caaggatgtg   900
gttcgccatc ctgttgtcgc tcagattatc cgagcctatg aatattctac tgaagttgca   960
cacgac                                                              966

<210>   1860
<211>   322
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PhoH family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902893 (0.E+01)

<400>   1860
Met Lys Glu His Ser Ile Asp Ile Gln Leu Ser His Pro Asp Asp Leu 
1               5                   10                  15      

Phe His Leu Phe Gly Ser Asn Glu Arg His Leu Arg Leu Met Glu Glu 
            20                  25                  30          

Glu Leu Asp Val Val Ile His Ala Arg Thr Glu Ile Val Gln Val Leu 
        35                  40                  45              

Gly Glu Glu Ser Ala Cys Glu Glu Ala Arg Gln Val Ile Gln Ala Leu 
    50                  55                  60                  

Met Val Leu Val Asn Arg Gly Met Thr Val Gly Thr Pro Asp Val Val 
65                  70                  75                  80  

Thr Ala Ile Ser Met Val Lys Asn Asp Glu Ile Asp Lys Phe Val Ala 
                85                  90                  95      

Leu Tyr Glu Glu Glu Ile Ile Lys Asp Asn Thr Gly Lys Pro Ile Arg 
            100                 105                 110         

Val Lys Thr Leu Gly Gln Lys Leu Tyr Val Asp Ser Val Lys Gln His 
        115                 120                 125             

Asp Val Thr Phe Gly Ile Gly Pro Ala Gly Thr Gly Lys Thr Phe Leu 
    130                 135                 140                 

Ala Val Thr Leu Ala Val Thr Ala Leu Lys Arg Gly Gln Val Lys Arg 
145                 150                 155                 160 

Ile Ile Leu Thr Arg Pro Ala Val Glu Ala Gly Glu Ser Leu Gly Phe 
                165                 170                 175     

Leu Pro Gly Asp Leu Lys Glu Lys Val Asp Pro Tyr Leu Arg Pro Val 
            180                 185                 190         

Tyr Asp Ala Leu Tyr Gln Ile Leu Gly Lys Asp Gln Thr Thr Arg Leu 
        195                 200                 205             

Met Glu Arg Glu Ile Ile Glu Ile Ala Pro Leu Ala Tyr Met Arg Gly 
    210                 215                 220                 

Arg Thr Leu Asp Asp Ala Phe Val Ile Leu Asp Glu Ala Gln Asn Thr 
225                 230                 235                 240 

Thr Ile Met Gln Met Lys Met Phe Leu Thr Arg Leu Gly Phe His Ser 
                245                 250                 255     

Lys Met Ile Val Asn Gly Asp Ile Ser Gln Ile Asp Leu Pro Arg Asn 
            260                 265                 270         

Val Lys Ser Gly Leu Ile Asp Ala Gln Glu Lys Leu Lys Asn Ile His 
        275                 280                 285             

Gln Ile Asp Phe Val His Phe Ser Ala Lys Asp Val Val Arg His Pro 
    290                 295                 300                 

Val Val Ala Gln Ile Ile Arg Ala Tyr Glu Tyr Ser Thr Glu Val Ala 
305                 310                 315                 320 

His Asp 
        

<210>   1861
<211>   812
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1861
atggaaacag tatacgacaa agcacaaaaa cttaactcaa aaaacttcaa actattgatt   60
ggtgtcaaaa aggaaacctt tcaactcatg ctagaacacc tgaattcagc ctatcagatt   120
cagcaccgaa aaggtggacg tccacgtagt ctgcccatgg aagaccagct cattatgacc   180
ctccgttact tgcgatatta tcccactcag cgtctgctgg cctttgattt tggcgtcggt   240
gtagctacgg taaatgccat catcacttgg gtggaggata cacttcgtgc gtcaggtagc   300
tttgatttgg accatttaga agccccgagt gctgctgtgg ctattgacgt gaccgaaagt   360
ccgattcagc gtccaaacaa aaccaaagca aaaattattc tggtaaaaag aaacgacaca   420
ccttaaaaac tcaaattatg ctggatttga cgacacataa agtctgtcaa atggcctttt   480
ctgacggaca tacgcatgat tttactctct tcaaagaaag tattggacaa agtttgcctg   540
aaacgacgct tgcctttgtt gacctaggtt atttaggcat cttgaaattt catgagaata   600
ctttcattcc tgctaaaaat tccaaaaatc gccgcctgag tgaggatgat aagcagttaa   660
ataaagagat gtcagcgata cgaattgaaa ttgaacattt taacgctaaa ttcaagacct   720
tccaaatcat gtcagtccct tatcgtaacc gcagaaaacg tttcgagtta cgggcggaat   780
taatttgtgc catcatcaat tatgaagtga ac                                 812

<210>   1862
<211>   153
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1515, transposase FRAMESHIFT

<400>   1862
Met Phe Gly Asn Cys Lys Lys Cys Tyr Thr Ile Phe Met Glu Thr Val 
1               5                   10                  15      

Tyr Asp Lys Ala Gln Lys Leu Asn Ser Lys Asn Phe Lys Leu Leu Ile 
            20                  25                  30          

Gly Val Lys Lys Glu Thr Phe Gln Leu Met Leu Glu His Leu Asn Ser 
        35                  40                  45              

Ala Tyr Gln Ile Gln His Arg Lys Gly Gly Arg Pro Arg Ser Leu Pro 
    50                  55                  60                  

Met Glu Asp Gln Leu Ile Met Thr Leu Arg Tyr Leu Arg Tyr Tyr Pro 
65                  70                  75                  80  

Thr Gln Arg Leu Leu Ala Phe Asp Phe Gly Val Gly Val Ala Thr Val 
                85                  90                  95      

Asn Ala Ile Ile Thr Trp Val Glu Asp Thr Leu Arg Ala Ser Gly Ser 
            100                 105                 110         

Phe Asp Leu Asp His Leu Glu Ala Pro Ser Ala Ala Val Ala Ile Asp 
        115                 120                 125             

Val Thr Glu Ser Pro Ile Gln Arg Pro Asn Lys Thr Lys Ala Lys Ile 
    130                 135                 140                 

Ile Leu Val Lys Arg Asn Asp Thr Pro 
145                 150             

<210>   1863
<211>   375
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1863
atgctggatt tgacgacaca taaagtctgt caaatggcct tttctgacgg acatacgcat   60
gattttactc tcttcaaaga aagtattgga caaagtttgc ctgaaacgac gcttgccttt   120
gttgacctag gttatttagg catcttgaaa tttcatgaga atactttcat tcctgctaaa   180
aattccaaaa atcgccgcct gagtgaggat gataagcagt taaataaaga gatgtcagcg   240
atacgaattg aaattgaaca ttttaacgct aaattcaaga ccttccaaat catgtcagtc   300
ccttatcgta accgcagaaa acgtttcgag ttacgggcgg aattaatttg tgccatcatc   360
aattatgaag tgaac                                                    375

<210>   1864
<211>   125
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   1864
Met Leu Asp Leu Thr Thr His Lys Val Cys Gln Met Ala Phe Ser Asp 
1               5                   10                  15      

Gly His Thr His Asp Phe Thr Leu Phe Lys Glu Ser Ile Gly Gln Ser 
            20                  25                  30          

Leu Pro Glu Thr Thr Leu Ala Phe Val Asp Leu Gly Tyr Leu Gly Ile 
        35                  40                  45              

Leu Lys Phe His Glu Asn Thr Phe Ile Pro Ala Lys Asn Ser Lys Asn 
    50                  55                  60                  

Arg Arg Leu Ser Glu Asp Asp Lys Gln Leu Asn Lys Glu Met Ser Ala 
65                  70                  75                  80  

Ile Arg Ile Glu Ile Glu His Phe Asn Ala Lys Phe Lys Thr Phe Gln 
                85                  90                  95      

Ile Met Ser Val Pro Tyr Arg Asn Arg Arg Lys Arg Phe Glu Leu Arg 
            100                 105                 110         

Ala Glu Leu Ile Cys Ala Ile Ile Asn Tyr Glu Val Asn 
        115                 120                 125 

<210>   1865
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1865
ttgcaaaatt tggctctggt ggacaatgct gaaaatacag aggattactt tcatataaag   60
ataaaatact tggaatatcc ttttcagtta gtatcctaca actgtaatac t            111

<210>   1866
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1866
Met Gln Asn Leu Ala Leu Val Asp Asn Ala Glu Asn Thr Glu Asp Tyr 
1               5                   10                  15      

Phe His Ile Lys Ile Lys Tyr Leu Glu Tyr Pro Phe Gln Leu Val Ser 
            20                  25                  30          

Tyr Asn Cys Asn Thr 
        35          

<210>   1867
<211>   498
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1867
atgattgacc aactatctaa gtattacagt tgtaggatac taactgaaaa ggatattcca   60
agtattttat ctttatatga aagtaatcct ctgtattttc agcattgtcc accagagcca   120
aattttgcaa ctgtaaaaga ggacatgctt tgtctacctg aaggtaaagc taaggctgat   180
aagttttttg ttggattttg gaatggatct gaccttgtgg ctgttatgga ttttgtctat   240
gcatatcctg atgaggagac tgtttttatt ggtttgttta tggttgatca agcctatcag   300
agaaaaggga ttggtagtca tattgtgaca gaagcactag cttattttgc taagaacttt   360
cgaaaggcac gtttggctta tgttaaggga aatccgcaat ctcagcattt ttgggaaaag   420
cagggcttta aatcaattgg atgcgaggtt aagcaagaac tctatacggt tgttatcgct   480
gaacagagcc tagaagat                                                 498

<210>   1868
<211>   166
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902894 (1.E-96)

<400>   1868
Met Ile Asp Gln Leu Ser Lys Tyr Tyr Ser Cys Arg Ile Leu Thr Glu 
1               5                   10                  15      

Lys Asp Ile Pro Ser Ile Leu Ser Leu Tyr Glu Ser Asn Pro Leu Tyr 
            20                  25                  30          

Phe Gln His Cys Pro Pro Glu Pro Asn Phe Ala Thr Val Lys Glu Asp 
        35                  40                  45              

Met Leu Cys Leu Pro Glu Gly Lys Ala Lys Ala Asp Lys Phe Phe Val 
    50                  55                  60                  

Gly Phe Trp Asn Gly Ser Asp Leu Val Ala Val Met Asp Phe Val Tyr 
65                  70                  75                  80  

Ala Tyr Pro Asp Glu Glu Thr Val Phe Ile Gly Leu Phe Met Val Asp 
                85                  90                  95      

Gln Ala Tyr Gln Arg Lys Gly Ile Gly Ser His Ile Val Thr Glu Ala 
            100                 105                 110         

Leu Ala Tyr Phe Ala Lys Asn Phe Arg Lys Ala Arg Leu Ala Tyr Val 
        115                 120                 125             

Lys Gly Asn Pro Gln Ser Gln His Phe Trp Glu Lys Gln Gly Phe Lys 
    130                 135                 140                 

Ser Ile Gly Cys Glu Val Lys Gln Glu Leu Tyr Thr Val Val Ile Ala 
145                 150                 155                 160 

Glu Gln Ser Leu Glu Asp 
                165     

<210>   1869
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1869
atggcatcaa gtaagaacta tttggaattt gttttggaac aattatcagg attagatgat   60
gtgacttacc gttccatgat gggggagtat attctttact tccgcggcaa gattattggc   120
ggcatttatg acgatcgctt tttagttaaa cccgtgcaag cagtcttaga taagattgac   180
caatcttctt ttgagtttcc atacaaaggt gccaaagaaa tgatt                   225

<210>   1870
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902895 (4.E-39)

<400>   1870
Met Ala Ser Ser Lys Asn Tyr Leu Glu Phe Val Leu Glu Gln Leu Ser 
1               5                   10                  15      

Gly Leu Asp Asp Val Thr Tyr Arg Ser Met Met Gly Glu Tyr Ile Leu 
            20                  25                  30          

Tyr Phe Arg Gly Lys Ile Ile Gly Gly Ile Tyr Asp Asp Arg Phe Leu 
        35                  40                  45              

Val Lys Pro Val Gln Ala Val Leu Asp Lys Ile Asp Gln Ser Ser Phe 
    50                  55                  60                  

Glu Phe Pro Tyr Lys Gly Ala Lys Glu Met Ile 
65                  70                  75  

<210>   1871
<211>   273
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1871
gtgacaacgc acgatgaacc cgtctatgaa aaacacggtg ttctccacta tgccgttgcc   60
aatatccctg gtgcggttgc tcgcacttca accatcgccc taaccaatgt cactcttcct   120
tatatcgaag ctttggctgg caaaggattc gcacaagcaa tctctgaaga tgaaggcttg   180
cgtcaaggtg tgactactta tcaaggttac ttgactaacc taccagttgc tcaaggactt   240
aatcgtgact acactgatat caatgattta gta                                273

<210>   1872
<211>   91
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alanine dehydrogenase-related

<400>   1872
Met Thr Thr His Asp Glu Pro Val Tyr Glu Lys His Gly Val Leu His 
1               5                   10                  15      

Tyr Ala Val Ala Asn Ile Pro Gly Ala Val Ala Arg Thr Ser Thr Ile 
            20                  25                  30          

Ala Leu Thr Asn Val Thr Leu Pro Tyr Ile Glu Ala Leu Ala Gly Lys 
        35                  40                  45              

Gly Phe Ala Gln Ala Ile Ser Glu Asp Glu Gly Leu Arg Gln Gly Val 
    50                  55                  60                  

Thr Thr Tyr Gln Gly Tyr Leu Thr Asn Leu Pro Val Ala Gln Gly Leu 
65                  70                  75                  80  

Asn Arg Asp Tyr Thr Asp Ile Asn Asp Leu Val 
                85                  90      

<210>   1873
<211>   1097
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1873
atgttaatcg gaatcccaaa agaaattaaa aataacgaaa accgtgtcgc cctcacacct   60
gcaggtgttc atagcttagt tagtcgtggt catcgtgtcc ttatcgaaac aaatgctggt   120
ctcggttctg gctttactga tgctgactat caaaagcaag gagctgagat tgtcgctact   180
gctggtgaag cttgggcagc agagttggtt gtgaaagtaa aagaatcttt aagttctgaa   240
tacggttact tgcgcgacga tcttcttctc ttcacctact tgcacatggc cgctgctcca   300
gaattagcag atgctatgtt aacagcaaaa acaactgaaa ctgttcgtga caatcaagga   360
caactaccgc tcctcgttcc tatgagtgag gttgcaggtc gtatggctgt tcaaatcgga   420
gctcacttcc ttactaagca agctggtggc tctggtgttc tacttggtgg tgtaccaggt   480
gttccaaaag gaaaagtaac tatcatcggt ggtggtgtcg tcggtacaca tgctgcccgc   540
atcgcccttg gtcttggtgc tcaagtgact attttagata ttagttccaa gcgtctctca   600
gttctagaag aagtctttgg aagtcaaatt caaactctta tgtctaattc attcaacatt   660
gaagcaagtg tgagagatgc tgatgtggtg attggagcca ttctcatccc tggtgcaaaa   720
gcaccggaat tggtgacaga tgagatggtc aaacaaatgc gtccaggctc tgtatcgttg   780
acgttgctgt tgaccaaggt ggcgttatcg aaacagctga ccgtgtgaca acgcacgatg   840
aacccgtcta tgaaaaacac ggtgttctcc actatgccgt tgccaatatc cctggtgcgg   900
ttgctcgcac ttcaaccatc gccctaacca atgtcactct tccttatatc gaagctttgg   960
ctggcaaagg attcgcacaa gcaatctctg aagatgaagg cttgcgtcaa ggtgtgacta   1020
cttatcaagg ttacttgact aacctaccag ttgctcaagg acttaatcgt gactacactg   1080
atatcaatga tttagta                                                  1097

<210>   1874
<211>   275
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alanine dehydrogenase, FRAMESHIFT (ald)

<400>   1874
Met Leu Ile Gly Ile Pro Lys Glu Ile Lys Asn Asn Glu Asn Arg Val 
1               5                   10                  15      

Ala Leu Thr Pro Ala Gly Val His Ser Leu Val Ser Arg Gly His Arg 
            20                  25                  30          

Val Leu Ile Glu Thr Asn Ala Gly Leu Gly Ser Gly Phe Thr Asp Ala 
        35                  40                  45              

Asp Tyr Gln Lys Gln Gly Ala Glu Ile Val Ala Thr Ala Gly Glu Ala 
    50                  55                  60                  

Trp Ala Ala Glu Leu Val Val Lys Val Lys Glu Ser Leu Ser Ser Glu 
65                  70                  75                  80  

Tyr Gly Tyr Leu Arg Asp Asp Leu Leu Leu Phe Thr Tyr Leu His Met 
                85                  90                  95      

Ala Ala Ala Pro Glu Leu Ala Asp Ala Met Leu Thr Ala Lys Thr Thr 
            100                 105                 110         

Glu Thr Val Arg Asp Asn Gln Gly Gln Leu Pro Leu Leu Val Pro Met 
        115                 120                 125             

Ser Glu Val Ala Gly Arg Met Ala Val Gln Ile Gly Ala His Phe Leu 
    130                 135                 140                 

Thr Lys Gln Ala Gly Gly Ser Gly Val Leu Leu Gly Gly Val Pro Gly 
145                 150                 155                 160 

Val Pro Lys Gly Lys Val Thr Ile Ile Gly Gly Gly Val Val Gly Thr 
                165                 170                 175     

His Ala Ala Arg Ile Ala Leu Gly Leu Gly Ala Gln Val Thr Ile Leu 
            180                 185                 190         

Asp Ile Ser Ser Lys Arg Leu Ser Val Leu Glu Glu Val Phe Gly Ser 
        195                 200                 205             

Gln Ile Gln Thr Leu Met Ser Asn Ser Phe Asn Ile Glu Ala Ser Val 
    210                 215                 220                 

Arg Asp Ala Asp Val Val Ile Gly Ala Ile Leu Ile Pro Gly Ala Lys 
225                 230                 235                 240 

Ala Pro Glu Leu Val Thr Asp Glu Met Val Lys Gln Met Arg Pro Gly 
                245                 250                 255     

Ser Val Ser Leu Thr Leu Leu Leu Thr Lys Val Ala Leu Ser Lys Gln 
            260                 265                 270         

Leu Thr Val 
        275 

<210>   1875
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1875
atggaatcaa tatttgtgaa atttgcccag tatccgtcta tagaaacgga gcgtttattg   60
ctcagacctg taactttgga tgatgcggaa gcaatgtttg actatgcctc ggacaagggt   120
aatacacgtt acacttttcc aaccaatcaa agcttggaag aaaccaagaa taacattgct   180
cagttctact tggctaatcc cttgggacgt tggggaatag aactaaaaag caatggtcag   240
tttattggaa ccattgactt gcacaagatt gattctgttc ttaagaaggc agctattggc   300
tacattatca ataaaaagta ttggaatcaa ggattaacga cagaagccaa tcgtgctgtg   360
attgagctag cttttgagaa gatagggatg aataagttga ctgcccttca cgataaggct   420
aatcccgcgt caggaaaggt catggagaaa tcaggcatgc gtttttccca tgcagaacca   480
tatgcttgta tggaccagca tgaaaaaggc cgaatcgtga caagagttca ttatgtcttg   540
accaaggaag actattttgc aaataaa                                       567

<210>   1876
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902899 (e-103)

<400>   1876
Met Glu Ser Ile Phe Val Lys Phe Ala Gln Tyr Pro Ser Ile Glu Thr 
1               5                   10                  15      

Glu Arg Leu Leu Leu Arg Pro Val Thr Leu Asp Asp Ala Glu Ala Met 
            20                  25                  30          

Phe Asp Tyr Ala Ser Asp Lys Gly Asn Thr Arg Tyr Thr Phe Pro Thr 
        35                  40                  45              

Asn Gln Ser Leu Glu Glu Thr Lys Asn Asn Ile Ala Gln Phe Tyr Leu 
    50                  55                  60                  

Ala Asn Pro Leu Gly Arg Trp Gly Ile Glu Leu Lys Ser Asn Gly Gln 
65                  70                  75                  80  

Phe Ile Gly Thr Ile Asp Leu His Lys Ile Asp Ser Val Leu Lys Lys 
                85                  90                  95      

Ala Ala Ile Gly Tyr Ile Ile Asn Lys Lys Tyr Trp Asn Gln Gly Leu 
            100                 105                 110         

Thr Thr Glu Ala Asn Arg Ala Val Ile Glu Leu Ala Phe Glu Lys Ile 
        115                 120                 125             

Gly Met Asn Lys Leu Thr Ala Leu His Asp Lys Ala Asn Pro Ala Ser 
    130                 135                 140                 

Gly Lys Val Met Glu Lys Ser Gly Met Arg Phe Ser His Ala Glu Pro 
145                 150                 155                 160 

Tyr Ala Cys Met Asp Gln His Glu Lys Gly Arg Ile Val Thr Arg Val 
                165                 170                 175     

His Tyr Val Leu Thr Lys Glu Asp Tyr Phe Ala Asn Lys 
            180                 185                 

<210>   1877
<211>   648
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1877
atggaagcaa ttatcgagaa aatcaaagag tataaaatca tcgtcatctg tactggtctg   60
ggcttgcttg taggaggatt tttcctgcta aaaccagctc cacaaacacc tgtcaaagag   120
acgaatttgc aggctgaagt tgcagctgtt tccaaggact catcgaccga aaaggaagtg   180
aagaaggaag aaaaggaaga accccttgaa caagatctaa tcacagtaga tgtcaaaggt   240
gctgtcaaat cgccagggat ttatgacttg cctgtaggta gtcgagtcaa tgatgctgtt   300
cagaaggctg gtggcttgac agagcaagca gacagcaagt cgctcaatct agctcagaaa   360
gttagtgatg aggctctggt ttacgttcct actaagggag aagaagcagt tagtcaacag   420
actggttcgg ggacagcttc ttcaacaagc aaggaaaaga aggtcaatct caacaaggcc   480
agtctggaag aactcaagca ggtcaaggga ctgggaggaa aacgagctca ggacattatt   540
gaccatcgtg aggcaaatgg caagttcaag tcagtagacg agctcaagaa ggtctctggc   600
attggtggca aaacaataga aaagcttaaa gactatgtta cagtggat                648

<210>   1878
<211>   216
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence protein CelA (celA)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902900 (e-113)

<400>   1878
Met Glu Ala Ile Ile Glu Lys Ile Lys Glu Tyr Lys Ile Ile Val Ile 
1               5                   10                  15      

Cys Thr Gly Leu Gly Leu Leu Val Gly Gly Phe Phe Leu Leu Lys Pro 
            20                  25                  30          

Ala Pro Gln Thr Pro Val Lys Glu Thr Asn Leu Gln Ala Glu Val Ala 
        35                  40                  45              

Ala Val Ser Lys Asp Ser Ser Thr Glu Lys Glu Val Lys Lys Glu Glu 
    50                  55                  60                  

Lys Glu Glu Pro Leu Glu Gln Asp Leu Ile Thr Val Asp Val Lys Gly 
65                  70                  75                  80  

Ala Val Lys Ser Pro Gly Ile Tyr Asp Leu Pro Val Gly Ser Arg Val 
                85                  90                  95      

Asn Asp Ala Val Gln Lys Ala Gly Gly Leu Thr Glu Gln Ala Asp Ser 
            100                 105                 110         

Lys Ser Leu Asn Leu Ala Gln Lys Val Ser Asp Glu Ala Leu Val Tyr 
        115                 120                 125             

Val Pro Thr Lys Gly Glu Glu Ala Val Ser Gln Gln Thr Gly Ser Gly 
    130                 135                 140                 

Thr Ala Ser Ser Thr Ser Lys Glu Lys Lys Val Asn Leu Asn Lys Ala 
145                 150                 155                 160 

Ser Leu Glu Glu Leu Lys Gln Val Lys Gly Leu Gly Gly Lys Arg Ala 
                165                 170                 175     

Gln Asp Ile Ile Asp His Arg Glu Ala Asn Gly Lys Phe Lys Ser Val 
            180                 185                 190         

Asp Glu Leu Lys Lys Val Ser Gly Ile Gly Gly Lys Thr Ile Glu Lys 
        195                 200                 205             

Leu Lys Asp Tyr Val Thr Val Asp 
    210                 215     

<210>   1879
<211>   1506
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1879
atgttacagt ggattaagaa tttctctatt cccctaattt acctgagttt tctattactt   60
tggctttatt acgctatttt ctcagcatct tatcttgctt tgttgggctt tgtttttctg   120
ctagtctgtc tctttatcca atttccgtgg aaatctgctg gtaaagttct aataatttgc   180
ggaatctttg gattttggtt tgtttttcaa aattggcaac agagtcaagc gagtcaaaat   240
ctggcggatt ctgttgaaag ggtacggatt ttgcctgata ctattaaggt taatggtgat   300
agtctatcct ttcgtggcaa gtctaacggt cgtgctttcc aagtctatta taaactccag   360
tccgaggagg agaaagaagc ctttcaagct ttaactgacc tgcatgagat aggactagaa   420
gggaagcttt cggagccaga agggcagaga aattttggtg gctttaatta ccaagcctat   480
ctgaagactc agggaattta ccagactctc aatatcaaaa caatccagtc acttcaaaag   540
attggcagtt gggatatagg agaaaacttg tccagtttac gtcgaaaggc tgtggtttgg   600
attaagacgc actttccaga ccctatgggc aattacatga caggactctt gctgggacat   660
ctggacaccg actttgagga gatgaatgag ctttattcca gtctaggaat tatccacctc   720
tttgccctat ctggcatgca ggtaggtttt ttcatgaatg gatttaagaa acttctcttg   780
cgattgggct tgacccaaga aaagttgaaa tggctgactt atcccttttc ccttatctat   840
gcgggactaa ctggattttc agcatcggtt attcgcagtc tcttgcaaaa gctactggct   900
caacatgggg ttaagggctt ggataatttt gccttgacgg tgcttgtcct ctttattgtc   960
atgccaaact ttttcttgac agcaggagga gtcttgtcct gcgcttatgc ttttatcctg   1020
accatgacca gcaaagaagg ggaggggctc aaggctgtta ctagtgaaag tctagtcatc   1080
tccttgggca tattgcccat tctatccttc tattttgcgg aatttcaacc ttggtctatc   1140
cttttgacct ttgtcttttc ctttcttttt gacttggtct tcttaccgct cttgtctatc   1200
ttatttgtcc tttcctttct ctatccagtc attcagctga actttatctt tgaatggtta   1260
gagggcatta ttcgcttggt ctcgcaggtg gcaaggagac cacttgtctt tggtcaaccc   1320
aacgcatggc ttttaatctt attgttaatt tccttggctt tggtctatga tttgaggaaa   1380
aacattaaag gattaacagt attgagttta ttgattacag gtctcttttt ccttaccaag   1440
tatccactgg aaaatgaaat caccatgctg gatgtggggc aaggagaaag tattttctac   1500
gggatg                                                              1506

<210>   1880
<211>   502
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence protein CelB, FRAMESHIFT (celB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902901 (0.E+01)

<400>   1880
Met Leu Gln Trp Ile Lys Asn Phe Ser Ile Pro Leu Ile Tyr Leu Ser 
1               5                   10                  15      

Phe Leu Leu Leu Trp Leu Tyr Tyr Ala Ile Phe Ser Ala Ser Tyr Leu 
            20                  25                  30          

Ala Leu Leu Gly Phe Val Phe Leu Leu Val Cys Leu Phe Ile Gln Phe 
        35                  40                  45              

Pro Trp Lys Ser Ala Gly Lys Val Leu Ile Ile Cys Gly Ile Phe Gly 
    50                  55                  60                  

Phe Trp Phe Val Phe Gln Asn Trp Gln Gln Ser Gln Ala Ser Gln Asn 
65                  70                  75                  80  

Leu Ala Asp Ser Val Glu Arg Val Arg Ile Leu Pro Asp Thr Ile Lys 
                85                  90                  95      

Val Asn Gly Asp Ser Leu Ser Phe Arg Gly Lys Ser Asn Gly Arg Ala 
            100                 105                 110         

Phe Gln Val Tyr Tyr Lys Leu Gln Ser Glu Glu Glu Lys Glu Ala Phe 
        115                 120                 125             

Gln Ala Leu Thr Asp Leu His Glu Ile Gly Leu Glu Gly Lys Leu Ser 
    130                 135                 140                 

Glu Pro Glu Gly Gln Arg Asn Phe Gly Gly Phe Asn Tyr Gln Ala Tyr 
145                 150                 155                 160 

Leu Lys Thr Gln Gly Ile Tyr Gln Thr Leu Asn Ile Lys Thr Ile Gln 
                165                 170                 175     

Ser Leu Gln Lys Ile Gly Ser Trp Asp Ile Gly Glu Asn Leu Ser Ser 
            180                 185                 190         

Leu Arg Arg Lys Ala Val Val Trp Ile Lys Thr His Phe Pro Asp Pro 
        195                 200                 205             

Met Gly Asn Tyr Met Thr Gly Leu Leu Leu Gly His Leu Asp Thr Asp 
    210                 215                 220                 

Phe Glu Glu Met Asn Glu Leu Tyr Ser Ser Leu Gly Ile Ile His Leu 
225                 230                 235                 240 

Phe Ala Leu Ser Gly Met Gln Val Gly Phe Phe Met Asn Gly Phe Lys 
                245                 250                 255     

Lys Leu Leu Leu Arg Leu Gly Leu Thr Gln Glu Lys Leu Lys Trp Leu 
            260                 265                 270         

Thr Tyr Pro Phe Ser Leu Ile Tyr Ala Gly Leu Thr Gly Phe Ser Ala 
        275                 280                 285             

Ser Val Ile Arg Ser Leu Leu Gln Lys Leu Leu Ala Gln His Gly Val 
    290                 295                 300                 

Lys Gly Leu Asp Asn Phe Ala Leu Thr Val Leu Val Leu Phe Ile Val 
305                 310                 315                 320 

Met Pro Asn Phe Phe Leu Thr Ala Gly Gly Val Leu Ser Cys Ala Tyr 
                325                 330                 335     

Ala Phe Ile Leu Thr Met Thr Ser Lys Glu Gly Glu Gly Leu Lys Ala 
            340                 345                 350         

Val Thr Ser Glu Ser Leu Val Ile Ser Leu Gly Ile Leu Pro Ile Leu 
        355                 360                 365             

Ser Phe Tyr Phe Ala Glu Phe Gln Pro Trp Ser Ile Leu Leu Thr Phe 
    370                 375                 380                 

Val Phe Ser Phe Leu Phe Asp Leu Val Phe Leu Pro Leu Leu Ser Ile 
385                 390                 395                 400 

Leu Phe Val Leu Ser Phe Leu Tyr Pro Val Ile Gln Leu Asn Phe Ile 
                405                 410                 415     

Phe Glu Trp Leu Glu Gly Ile Ile Arg Leu Val Ser Gln Val Ala Arg 
            420                 425                 430         

Arg Pro Leu Val Phe Gly Gln Pro Asn Ala Trp Leu Leu Ile Leu Leu 
        435                 440                 445             

Leu Ile Ser Leu Ala Leu Val Tyr Asp Leu Arg Lys Asn Ile Lys Gly 
    450                 455                 460                 

Leu Thr Val Leu Ser Leu Leu Ile Thr Gly Leu Phe Phe Leu Thr Lys 
465                 470                 475                 480 

Tyr Pro Leu Glu Asn Glu Ile Thr Met Leu Asp Val Gly Gln Gly Glu 
                485                 490                 495     

Ser Ile Phe Tyr Gly Met 
            500         

<210>   1881
<211>   654
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1881
atgacgacca gcaatgccca gcgaaccttg attccctatc tcaaaagtcg aggagtagct   60
aagattgacc agctaatttt gactaacacg gacaaggagc atgttggaga tttgtcagag   120
atgaccaagg ctttccatgt aggggagatt ctagtatcaa aagacagtct gaaacagaag   180
gaatttgtgg cagaactaca ggcgactcaa acaaaggtgc gtagtatgat agtaggggag   240
aacttgccca tttttggaag tcagttagaa gttctatctc caaggaaaat gggagatgga   300
ggacacgatg ataccctagt tctgtatggg aaattcttgg ataagcaatt tctcttcacg   360
ggaaatttgg aggagaaagg agagaaggac ttgctgaagc actatccaga cttgaaagta   420
aatgttttga aagctagcca acatggcaat aaaaaatcat caagtccagc ctttctagaa   480
aaactcaaac cagagcttac tcttatctca gttggaaaga gcaatcgaat gaaactcccc   540
catcaggaaa cattgacacg actggaaggt atcaatagca aagtttatcg aactgaccag   600
caaggagcta tacgttttaa ggggttggat agttggaaaa tcgaaagtgt tcga         654

<210>   1882
<211>   218
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence protein-related

<400>   1882
Met Thr Thr Ser Asn Ala Gln Arg Thr Leu Ile Pro Tyr Leu Lys Ser 
1               5                   10                  15      

Arg Gly Val Ala Lys Ile Asp Gln Leu Ile Leu Thr Asn Thr Asp Lys 
            20                  25                  30          

Glu His Val Gly Asp Leu Ser Glu Met Thr Lys Ala Phe His Val Gly 
        35                  40                  45              

Glu Ile Leu Val Ser Lys Asp Ser Leu Lys Gln Lys Glu Phe Val Ala 
    50                  55                  60                  

Glu Leu Gln Ala Thr Gln Thr Lys Val Arg Ser Met Ile Val Gly Glu 
65                  70                  75                  80  

Asn Leu Pro Ile Phe Gly Ser Gln Leu Glu Val Leu Ser Pro Arg Lys 
                85                  90                  95      

Met Gly Asp Gly Gly His Asp Asp Thr Leu Val Leu Tyr Gly Lys Phe 
            100                 105                 110         

Leu Asp Lys Gln Phe Leu Phe Thr Gly Asn Leu Glu Glu Lys Gly Glu 
        115                 120                 125             

Lys Asp Leu Leu Lys His Tyr Pro Asp Leu Lys Val Asn Val Leu Lys 
    130                 135                 140                 

Ala Ser Gln His Gly Asn Lys Lys Ser Ser Ser Pro Ala Phe Leu Glu 
145                 150                 155                 160 

Lys Leu Lys Pro Glu Leu Thr Leu Ile Ser Val Gly Lys Ser Asn Arg 
                165                 170                 175     

Met Lys Leu Pro His Gln Glu Thr Leu Thr Arg Leu Glu Gly Ile Asn 
            180                 185                 190         

Ser Lys Val Tyr Arg Thr Asp Gln Gln Gly Ala Ile Arg Phe Lys Gly 
        195                 200                 205             

Leu Asp Ser Trp Lys Ile Glu Ser Val Arg 
    210                 215             

<210>   1883
<211>   186
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1883
gtgacagtca ctaaaagtta caagtatgat tggaatacgg tttgggaata tagtaccaac   60
tatcacgacc atcagtatgc ttggattccg tcatggtctc gttatgacag ctattctgag   120
tataaagttg gcggaggctg gaactacgct cgttatgagg tcataaacta ttacagcgga   180
ggctat                                                              186

<210>   1884
<211>   62
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902902 (2.E-34)

<400>   1884
Met Thr Val Thr Lys Ser Tyr Lys Tyr Asp Trp Asn Thr Val Trp Glu 
1               5                   10                  15      

Tyr Ser Thr Asn Tyr His Asp His Gln Tyr Ala Trp Ile Pro Ser Trp 
            20                  25                  30          

Ser Arg Tyr Asp Ser Tyr Ser Glu Tyr Lys Val Gly Gly Gly Trp Asn 
        35                  40                  45              

Tyr Ala Arg Tyr Glu Val Ile Asn Tyr Tyr Ser Gly Gly Tyr 
    50                  55                  60          

<210>   1885
<211>   585
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1885
atgttgcagc ttactcatgt gaccttaaaa acgcgacaag tcatcttgca agatgtggat   60
ttcaccttta aaaagggtag ggtttatggt cttcttgcta tcaatggctc tggaaagacg   120
accctgttcc gtgccattag caatttaatt cccataagta gtggaaatat cgcagcccct   180
ccttctttat tttattatga gagtattgaa tggctggatg gaaacttaag tgggatggac   240
taccttcgtc ttatcaaaaa catctggaag tcaggtctga acttgaggga tgaaatcgcc   300
tattgggaaa tgtctgacta tatcagtctt cccattcgca agtattcctt aggcatgaag   360
caacgcttgg tgattgccat gtatttcctc agtcaggcca aatgctggct catggatgag   420
attacaaatg gcttagatga gtattatcga cagaagtttt ttgataggct agcacaaatc   480
gatagacaag aacagctggt tcttttaagt tcccactata aggaagagtt ggttgatgtc   540
tgcgatagag tagtaaccat tcatcagggg cagatagaag aggtt                   585

<210>   1886
<211>   195
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902903 (2.E-84)

<400>   1886
Met Leu Gln Leu Thr His Val Thr Leu Lys Thr Arg Gln Val Ile Leu 
1               5                   10                  15      

Gln Asp Val Asp Phe Thr Phe Lys Lys Gly Arg Val Tyr Gly Leu Leu 
            20                  25                  30          

Ala Ile Asn Gly Ser Gly Lys Thr Thr Leu Phe Arg Ala Ile Ser Asn 
        35                  40                  45              

Leu Ile Pro Ile Ser Ser Gly Asn Ile Ala Ala Pro Pro Ser Leu Phe 
    50                  55                  60                  

Tyr Tyr Glu Ser Ile Glu Trp Leu Asp Gly Asn Leu Ser Gly Met Asp 
65                  70                  75                  80  

Tyr Leu Arg Leu Ile Lys Asn Ile Trp Lys Ser Gly Leu Asn Leu Arg 
                85                  90                  95      

Asp Glu Ile Ala Tyr Trp Glu Met Ser Asp Tyr Ile Ser Leu Pro Ile 
            100                 105                 110         

Arg Lys Tyr Ser Leu Gly Met Lys Gln Arg Leu Val Ile Ala Met Tyr 
        115                 120                 125             

Phe Leu Ser Gln Ala Lys Cys Trp Leu Met Asp Glu Ile Thr Asn Gly 
    130                 135                 140                 

Leu Asp Glu Tyr Tyr Arg Gln Lys Phe Phe Asp Arg Leu Ala Gln Ile 
145                 150                 155                 160 

Asp Arg Gln Glu Gln Leu Val Leu Leu Ser Ser His Tyr Lys Glu Glu 
                165                 170                 175     

Leu Val Asp Val Cys Asp Arg Val Val Thr Ile His Gln Gly Gln Ile 
            180                 185                 190         

Glu Glu Val 
        195 

<210>   1887
<211>   1182
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1887
atgaaagatg ttagtctatt tttattgaaa aaagttttca aaagccgctt aaactggatt   60
gtcttagctt tatttgtatc tgtactcggt gttacctttt atttaaatag tcagactgca   120
aactcacaca gcttggagag caggttggaa agtcgcattg cagccaacga gagggctatc   180
aatgaaaatg aagagaaact ctcccaaatg tctgatacca gctcggagga ataccagttt   240
gctaaaaata atttagacgt gcaaaaaaat cttttgacgc gaaagacaga aattctgact   300
ttattaaaag aagggcgctg gaaagaagcc tactatttgc agtggcaaga tgaagagaag   360
aattatgaat ttgtatcaaa tgacccgact gctagccctg gcttaaaaat gggggttgac   420
cgcgaacgga agatttacca agccctgtat cccttgaaca taaaagcaca tactttggag   480
tttccgaccc acgggattga tcagattgtc tggattttag aggttatcat cccaagtttg   540
tttgtggttg ctattatttt tatgctaaca caactatttg cagaaagata tcaaaatcat   600
ctggacacag ctcacttata tcctgtttca aaagtgacat ttgcaatatc ctctcttgga   660
gttggagtgg gatatgtaac tgtgctgttt atcggaatct gtggcttttc ttttctagtg   720
ggaagtctga taagtggttt tggacagtta gattatccct acccaattta tagcttagtg   780
aatcaagaag taactattgg gaaaatacaa gatgtattat ttcctggctt gctcttagct   840
ttcttagcct ttatcgtcat tgtggaagtt gtgtacttga ttgcttactt tttcaagcaa   900
aaaatgcctg tcctctttct ttcactcatt gggattgttg gcttattgtt tggtatccaa   960
accattcagc ctcttcaaag gattgcacat ctgattccct ttacttactt gcgttcagtg   1020
gagattttat ctggaagatt acctaagcag attgataatg tcgatctaaa ttggagcatg   1080
ggaatggtct tacttccttg cctgattatc tttttgctat tgggaattct atttattgaa   1140
agatggggaa gttcacagaa aaaagaattt tttaatagat tc                      1182

<210>   1888
<211>   394
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902904 (0.E+01)

<400>   1888
Met Lys Asp Val Ser Leu Phe Leu Leu Lys Lys Val Phe Lys Ser Arg 
1               5                   10                  15      

Leu Asn Trp Ile Val Leu Ala Leu Phe Val Ser Val Leu Gly Val Thr 
            20                  25                  30          

Phe Tyr Leu Asn Ser Gln Thr Ala Asn Ser His Ser Leu Glu Ser Arg 
        35                  40                  45              

Leu Glu Ser Arg Ile Ala Ala Asn Glu Arg Ala Ile Asn Glu Asn Glu 
    50                  55                  60                  

Glu Lys Leu Ser Gln Met Ser Asp Thr Ser Ser Glu Glu Tyr Gln Phe 
65                  70                  75                  80  

Ala Lys Asn Asn Leu Asp Val Gln Lys Asn Leu Leu Thr Arg Lys Thr 
                85                  90                  95      

Glu Ile Leu Thr Leu Leu Lys Glu Gly Arg Trp Lys Glu Ala Tyr Tyr 
            100                 105                 110         

Leu Gln Trp Gln Asp Glu Glu Lys Asn Tyr Glu Phe Val Ser Asn Asp 
        115                 120                 125             

Pro Thr Ala Ser Pro Gly Leu Lys Met Gly Val Asp Arg Glu Arg Lys 
    130                 135                 140                 

Ile Tyr Gln Ala Leu Tyr Pro Leu Asn Ile Lys Ala His Thr Leu Glu 
145                 150                 155                 160 

Phe Pro Thr His Gly Ile Asp Gln Ile Val Trp Ile Leu Glu Val Ile 
                165                 170                 175     

Ile Pro Ser Leu Phe Val Val Ala Ile Ile Phe Met Leu Thr Gln Leu 
            180                 185                 190         

Phe Ala Glu Arg Tyr Gln Asn His Leu Asp Thr Ala His Leu Tyr Pro 
        195                 200                 205             

Val Ser Lys Val Thr Phe Ala Ile Ser Ser Leu Gly Val Gly Val Gly 
    210                 215                 220                 

Tyr Val Thr Val Leu Phe Ile Gly Ile Cys Gly Phe Ser Phe Leu Val 
225                 230                 235                 240 

Gly Ser Leu Ile Ser Gly Phe Gly Gln Leu Asp Tyr Pro Tyr Pro Ile 
                245                 250                 255     

Tyr Ser Leu Val Asn Gln Glu Val Thr Ile Gly Lys Ile Gln Asp Val 
            260                 265                 270         

Leu Phe Pro Gly Leu Leu Leu Ala Phe Leu Ala Phe Ile Val Ile Val 
        275                 280                 285             

Glu Val Val Tyr Leu Ile Ala Tyr Phe Phe Lys Gln Lys Met Pro Val 
    290                 295                 300                 

Leu Phe Leu Ser Leu Ile Gly Ile Val Gly Leu Leu Phe Gly Ile Gln 
305                 310                 315                 320 


Thr Ile Gln Pro Leu Gln Arg Ile Ala His Leu Ile Pro Phe Thr Tyr 
                325                 330                 335     

Leu Arg Ser Val Glu Ile Leu Ser Gly Arg Leu Pro Lys Gln Ile Asp 
            340                 345                 350         

Asn Val Asp Leu Asn Trp Ser Met Gly Met Val Leu Leu Pro Cys Leu 
        355                 360                 365             

Ile Ile Phe Leu Leu Leu Gly Ile Leu Phe Ile Glu Arg Trp Gly Ser 
    370                 375                 380                 

Ser Gln Lys Lys Glu Phe Phe Asn Arg Phe 
385                 390                 

<210>   1889
<211>   585
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1889
gtgcgggctt gtatatttac aagtccgcta ttgtttttct ctaataaaac aaaagaggtg   60
aaaaccatag caaagcaaga cttattcatc aatgatgaga ttcgtgtacg tgaagttcgc   120
ttgattggtc ttgaaggaga acagctaggt atcaagccac tcagtgaagc gcaagctttg   180
gctgataacg ctaatgttga cctagtattg attcaacccc aagccaaacc gcctgttgca   240
aaaattatgg actacggtaa gttcaaattt gagtaccaga agaagcaaaa agaacaacgt   300
aaaaaacaaa gcgttgttac tgtgaaagaa gttcgtctaa gtccaacaat tgacaagggt   360
gactttgata caaaacttcg taatgcacgt aagttccttg aaaaaggaaa taaagttaag   420
gtatctattc gctttaaggg tcgtatgatt acccataaag agattggtgc aaaagtttta   480
gccgagtttg ctgaagcaac tcaagatatt gccatcatcg aacaacgtgc taaaatggat   540
ggacgtcaaa tgttcatgca attggcgcca gcgactgaca aaaaa                   585

<210>   1890
<211>   195
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   translation initiation factor IF-3 (infC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902905 (e-100)

<400>   1890
Met Arg Ala Cys Ile Phe Thr Ser Pro Leu Leu Phe Phe Ser Asn Lys 
1               5                   10                  15      

Thr Lys Glu Val Lys Thr Ile Ala Lys Gln Asp Leu Phe Ile Asn Asp 
            20                  25                  30          

Glu Ile Arg Val Arg Glu Val Arg Leu Ile Gly Leu Glu Gly Glu Gln 
        35                  40                  45              

Leu Gly Ile Lys Pro Leu Ser Glu Ala Gln Ala Leu Ala Asp Asn Ala 
    50                  55                  60                  

Asn Val Asp Leu Val Leu Ile Gln Pro Gln Ala Lys Pro Pro Val Ala 
65                  70                  75                  80  

Lys Ile Met Asp Tyr Gly Lys Phe Lys Phe Glu Tyr Gln Lys Lys Gln 
                85                  90                  95      

Lys Glu Gln Arg Lys Lys Gln Ser Val Val Thr Val Lys Glu Val Arg 
            100                 105                 110         

Leu Ser Pro Thr Ile Asp Lys Gly Asp Phe Asp Thr Lys Leu Arg Asn 
        115                 120                 125             

Ala Arg Lys Phe Leu Glu Lys Gly Asn Lys Val Lys Val Ser Ile Arg 
    130                 135                 140                 

Phe Lys Gly Arg Met Ile Thr His Lys Glu Ile Gly Ala Lys Val Leu 
145                 150                 155                 160 

Ala Glu Phe Ala Glu Ala Thr Gln Asp Ile Ala Ile Ile Glu Gln Arg 
                165                 170                 175     

Ala Lys Met Asp Gly Arg Gln Met Phe Met Gln Leu Ala Pro Ala Thr 
            180                 185                 190         

Asp Lys Lys 
        195 

<210>   1891
<211>   198
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1891
atgccaaaac aaaaaacaca ccgcgcatca gctaaacgtt tcaaacgtac aggttctggt   60
ggacttaaac gtttccgtgc ttacacttct caccgtttcc acggaaaaac taagaaacaa   120
cgtcgtcatc ttcgtaaagc atctatggtg cattcaggag attacaaacg tatcaaagca   180
atgcttactc gcttgaaa                                                 198

<210>   1892
<211>   66
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L35 (rpmI)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902906 (8.E-35)

<400>   1892
Met Pro Lys Gln Lys Thr His Arg Ala Ser Ala Lys Arg Phe Lys Arg 
1               5                   10                  15      

Thr Gly Ser Gly Gly Leu Lys Arg Phe Arg Ala Tyr Thr Ser His Arg 
            20                  25                  30          

Phe His Gly Lys Thr Lys Lys Gln Arg Arg His Leu Arg Lys Ala Ser 
        35                  40                  45              

Met Val His Ser Gly Asp Tyr Lys Arg Ile Lys Ala Met Leu Thr Arg 
    50                  55                  60                  

Leu Lys 
65      

<210>   1893
<211>   357
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1893
atggcacgtg ttaaaggtgg cgttgtatca cgcaaacgtc gtaaacgtat tcttaaatta   60
gcaaaaggtt actatggagc taaacacatc ttgttccgta ctgcaaaaga acaagtaatg   120
aactcttact actatgcata ccgtgaccgt cgtcagaaaa aacgtgactt ccgcaaattg   180
tggattactc gtatcaatgc ggcagctcgt atgaacggac tttcatactc acaattgatg   240
catggtttga aattggctga gatcgaagtt aaccgtaaaa tgcttgctga cttggctgtt   300
aacgatgcag tagctttcac agctcttgca gatgcagcta aagcaaaact tggtaaa      357

<210>   1894
<211>   119
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L20 (rplT)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902907 (2.E-63)

<400>   1894
Met Ala Arg Val Lys Gly Gly Val Val Ser Arg Lys Arg Arg Lys Arg 
1               5                   10                  15      

Ile Leu Lys Leu Ala Lys Gly Tyr Tyr Gly Ala Lys His Ile Leu Phe 
            20                  25                  30          

Arg Thr Ala Lys Glu Gln Val Met Asn Ser Tyr Tyr Tyr Ala Tyr Arg 
        35                  40                  45              


Asp Arg Arg Gln Lys Lys Arg Asp Phe Arg Lys Leu Trp Ile Thr Arg 
    50                  55                  60                  

Ile Asn Ala Ala Ala Arg Met Asn Gly Leu Ser Tyr Ser Gln Leu Met 
65                  70                  75                  80  

His Gly Leu Lys Leu Ala Glu Ile Glu Val Asn Arg Lys Met Leu Ala 
                85                  90                  95      

Asp Leu Ala Val Asn Asp Ala Val Ala Phe Thr Ala Leu Ala Asp Ala 
            100                 105                 110         

Ala Lys Ala Lys Leu Gly Lys 
        115                 

<210>   1895
<211>   429
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1895
atgagactgg aacaggattg tccagtcttt tttaaaataa aggagaaaga tatggcttca   60
aaaatgctac acacttgctt acgagtagaa aatcttgaaa aatcaatcgc attttatcaa   120
gatgcttttg gttttaaaga attgcgtcgc agagattttc cagaccatgc cttcacgatt   180
gtctatctag gtcttgaggg cgatgactat gagttggagt tgacttataa ctacgatcac   240
ggtccgtatg tggttggtga tgggtttgcc catatcgccc tcagtacacc tgatcttgag   300
gcacttcatc aagaacacag tgcaaaaggc tatgaagtga ctgagccaaa tggtctacca   360
ggaactacac caaactatta ctttgtcaaa gaccctgatg gatataaggt cgaagtcatt   420
cgtgaaaaa                                                           429

<210>   1896
<211>   143
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lactoylglutathione lyase (gloA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902908 (2.E-73)

<400>   1896
Met Arg Leu Glu Gln Asp Cys Pro Val Phe Phe Lys Ile Lys Glu Lys 
1               5                   10                  15      

Asp Met Ala Ser Lys Met Leu His Thr Cys Leu Arg Val Glu Asn Leu 
            20                  25                  30          

Glu Lys Ser Ile Ala Phe Tyr Gln Asp Ala Phe Gly Phe Lys Glu Leu 
        35                  40                  45              

Arg Arg Arg Asp Phe Pro Asp His Ala Phe Thr Ile Val Tyr Leu Gly 
    50                  55                  60                  

Leu Glu Gly Asp Asp Tyr Glu Leu Glu Leu Thr Tyr Asn Tyr Asp His 
65                  70                  75                  80  

Gly Pro Tyr Val Val Gly Asp Gly Phe Ala His Ile Ala Leu Ser Thr 
                85                  90                  95      

Pro Asp Leu Glu Ala Leu His Gln Glu His Ser Ala Lys Gly Tyr Glu 
            100                 105                 110         

Val Thr Glu Pro Asn Gly Leu Pro Gly Thr Thr Pro Asn Tyr Tyr Phe 
        115                 120                 125             

Val Lys Asp Pro Asp Gly Tyr Lys Val Glu Val Ile Arg Glu Lys 
    130                 135                 140             

<210>   1897
<211>   798
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1897
atgaatccca catgtaagaa gcgtttgggt gtcattcggt tggaaaccat gaaggtggtt   60
gcacaagagg aaatcgcgcc agcaatcttt gaattagtcc tagaaggaga aatggttgaa   120
gccatgcgag caggccaatt tcttcatctg cgtgtaccgg acgatgccca tctcttacgt   180
cgtcctattt caatttcgtc tattgacaag gcaaacaagc agtgtcacct catttatcgg   240
attgacggag ctgggactgc aattttttca accttaagtc agggagacac tcttgatgtg   300
atggggcctc agggaaatgg ttttgacttg tctgaccttg atgagcagaa tcaggttctc   360
cttgttggtg gtgggattgg tgttccaccc ttgcttgagg tggccaagga attgcatgaa   420
cgtggagtga aagtagtgac agtcctcggt tttgctaata aggatgctgt tattttgaaa   480
acggaattgg ctcagtatgg tcaggtcttt gtaacgacag atgatggttc ttatggcatc   540
aagggaaatg tttccgttgt tatcaatgat ttagacagtc agtttgatgc tgtttactcg   600
tgtggggctc caggaatgat gaagtatatc aatcaaacct ttgatgatca cccaagagcc   660
tatttatctc tggaatctcg tatggcttgt gggatgggag cttgctatgc ctgtgttcta   720
aaagtaccag aaaacgagac ggtcagccaa cgcgtctgtg aagatggtcc tgttttccgc   780
acaggaacag ttgtatta                                                 798

<210>   1898
<211>   266
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydroorotate dehydrogenase, electron transfer subunit (pyrK)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902909 (e-142)

<400>   1898
Met Asn Pro Thr Cys Lys Lys Arg Leu Gly Val Ile Arg Leu Glu Thr 
1               5                   10                  15      

Met Lys Val Val Ala Gln Glu Glu Ile Ala Pro Ala Ile Phe Glu Leu 
            20                  25                  30          

Val Leu Glu Gly Glu Met Val Glu Ala Met Arg Ala Gly Gln Phe Leu 
        35                  40                  45              

His Leu Arg Val Pro Asp Asp Ala His Leu Leu Arg Arg Pro Ile Ser 
    50                  55                  60                  

Ile Ser Ser Ile Asp Lys Ala Asn Lys Gln Cys His Leu Ile Tyr Arg 
65                  70                  75                  80  

Ile Asp Gly Ala Gly Thr Ala Ile Phe Ser Thr Leu Ser Gln Gly Asp 
                85                  90                  95      

Thr Leu Asp Val Met Gly Pro Gln Gly Asn Gly Phe Asp Leu Ser Asp 
            100                 105                 110         

Leu Asp Glu Gln Asn Gln Val Leu Leu Val Gly Gly Gly Ile Gly Val 
        115                 120                 125             

Pro Pro Leu Leu Glu Val Ala Lys Glu Leu His Glu Arg Gly Val Lys 
    130                 135                 140                 

Val Val Thr Val Leu Gly Phe Ala Asn Lys Asp Ala Val Ile Leu Lys 
145                 150                 155                 160 

Thr Glu Leu Ala Gln Tyr Gly Gln Val Phe Val Thr Thr Asp Asp Gly 
                165                 170                 175     

Ser Tyr Gly Ile Lys Gly Asn Val Ser Val Val Ile Asn Asp Leu Asp 
            180                 185                 190         

Ser Gln Phe Asp Ala Val Tyr Ser Cys Gly Ala Pro Gly Met Met Lys 
        195                 200                 205             

Tyr Ile Asn Gln Thr Phe Asp Asp His Pro Arg Ala Tyr Leu Ser Leu 
    210                 215                 220                 

Glu Ser Arg Met Ala Cys Gly Met Gly Ala Cys Tyr Ala Cys Val Leu 
225                 230                 235                 240 

Lys Val Pro Glu Asn Glu Thr Val Ser Gln Arg Val Cys Glu Asp Gly 
                245                 250                 255     

Pro Val Phe Arg Thr Gly Thr Val Val Leu 
            260                 265     

<210>   1899
<211>   936
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1899
atgactacaa atcgattaca agtttctcta cctggtttgg atttgaaaaa tccgattatt   60
ccagcatcag gctgttttgg ctttggacaa gagtatgcca agtactatga tttagacctt   120
ttaggttcta ttatgatcaa ggcgacaacc cttgaaccac gttttgggaa tccaactcca   180
agagtggcag agacgcctgc tggtatgctc aatgcaattg gcttgcaaaa tcctggttta   240
gaggttgttt tggctgaaaa gctaccttgg ctggaaagag aatatccaaa tcttcctatt   300
attgccaatg tagctggttt ttcaaaacaa gagtatgcag ctgtttctca tgggatttcc   360
aaggcaacta atgtaaaagc tatcgagctc aatatttctt gtcccaatgt tgaccactgt   420
aatcatggac ttttgattgg tcaagatcca gatttggctt atgatgtggt gaaagcagct   480
gtggaagcct cagaagtgcc agtttatgtc aaattaaccc cgagtgtgac cgatatcgtt   540
actgtcgcaa aagctgcaga agatgcggga gcaagtggct tgaccatgat caatactctg   600
gttggaatgc gctttgacct caaaactaga aaaccaatct tggccaatgg aacaggtgga   660
atgtctggtc cagcagtctt tccagtagcc ctcaaactca tccgccaagt tgcccaaaca   720
acagacctgc ctatcattgg aatgggagga gtggattcgg ctgaagctgc cctagaaatg   780
tatctggctg gggcatctgc tatcggagtt ggaacagcta actttaccaa tccttatgcc   840
tgccctgaca tcatcgaaaa tttaccaaaa gtcatggata aatacggtat tagcagtctg   900
gaagaactcc gtcaggaagt aaaagagtct ctgagg                             936

<210>   1900
<211>   312
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydroorotate dehydrogenase B (pyrDb)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902910 (e-177)

<400>   1900
Met Thr Thr Asn Arg Leu Gln Val Ser Leu Pro Gly Leu Asp Leu Lys 
1               5                   10                  15      

Asn Pro Ile Ile Pro Ala Ser Gly Cys Phe Gly Phe Gly Gln Glu Tyr 
            20                  25                  30          

Ala Lys Tyr Tyr Asp Leu Asp Leu Leu Gly Ser Ile Met Ile Lys Ala 
        35                  40                  45              

Thr Thr Leu Glu Pro Arg Phe Gly Asn Pro Thr Pro Arg Val Ala Glu 
    50                  55                  60                  

Thr Pro Ala Gly Met Leu Asn Ala Ile Gly Leu Gln Asn Pro Gly Leu 
65                  70                  75                  80  

Glu Val Val Leu Ala Glu Lys Leu Pro Trp Leu Glu Arg Glu Tyr Pro 
                85                  90                  95      

Asn Leu Pro Ile Ile Ala Asn Val Ala Gly Phe Ser Lys Gln Glu Tyr 
            100                 105                 110         

Ala Ala Val Ser His Gly Ile Ser Lys Ala Thr Asn Val Lys Ala Ile 
        115                 120                 125             

Glu Leu Asn Ile Ser Cys Pro Asn Val Asp His Cys Asn His Gly Leu 
    130                 135                 140                 

Leu Ile Gly Gln Asp Pro Asp Leu Ala Tyr Asp Val Val Lys Ala Ala 
145                 150                 155                 160 

Val Glu Ala Ser Glu Val Pro Val Tyr Val Lys Leu Thr Pro Ser Val 
                165                 170                 175     

Thr Asp Ile Val Thr Val Ala Lys Ala Ala Glu Asp Ala Gly Ala Ser 
            180                 185                 190         

Gly Leu Thr Met Ile Asn Thr Leu Val Gly Met Arg Phe Asp Leu Lys 
        195                 200                 205             

Thr Arg Lys Pro Ile Leu Ala Asn Gly Thr Gly Gly Met Ser Gly Pro 
    210                 215                 220                 

Ala Val Phe Pro Val Ala Leu Lys Leu Ile Arg Gln Val Ala Gln Thr 
225                 230                 235                 240 

Thr Asp Leu Pro Ile Ile Gly Met Gly Gly Val Asp Ser Ala Glu Ala 
                245                 250                 255     

Ala Leu Glu Met Tyr Leu Ala Gly Ala Ser Ala Ile Gly Val Gly Thr 
            260                 265                 270         

Ala Asn Phe Thr Asn Pro Tyr Ala Cys Pro Asp Ile Ile Glu Asn Leu 
        275                 280                 285             

Pro Lys Val Met Asp Lys Tyr Gly Ile Ser Ser Leu Glu Glu Leu Arg 
    290                 295                 300                 

Gln Glu Val Lys Glu Ser Leu Arg 
305                 310         

<210>   1901
<211>   2031
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1901

atgaatttag gagaattttg gtacaataaa ataaataaga acagaggaag aaggttaatg   60
aagaaagtaa gatttatttt tttagctctg ctatttttct tagctagtcc agagggtgca   120
atggctagtg atggtacttg gcaaggaaaa cagtatctga aagaagatgg cagtcaagca   180
gcaaatgagt gggtttttga tactcattat caatcttggt tctatataaa agcagatgct   240
aactatgctg aaaatgaatg gctaaagcaa ggtgacgact atttttacct caaatctggt   300
ggctatatgg ccaaatcaga atgggtagaa gacaagggag ccttttatta tcttgaccaa   360
gatggaaaga tgaaaagaaa tgcttgggta ggaacttcct atgttggtgc aacaggtgcc   420
aaagtaatag aagactgggt ctatgattct caatacgatg cttggtttta tatcaaagca   480
gatggacagc acgcagagaa agaatggctc caaattaaag ggaaggacta ttatttcaaa   540
tccggtggtt atctactgac aagtcagtgg attaatcaag cttatgtgaa tgctagtggt   600
gccaaagtac agcaaggttg gctttttgac aaacaatacc aatcttggtt ttacatcaaa   660
gaaaatggaa actatgctga taaagaatgg attttcgaga atggtcacta ttattatcta   720
aaatccggtg gctacatggc agccaatgaa tggatttggg ataaggaatc ttggttttat   780
ctcaaatttg atgggaaaat ggctgaaaaa gaatgggtct acgattctca tagtcaagct   840
tggtactact tcaaatccgg tggttacatg acagccaatg aatggatttg ggataaggaa   900
tcttggtttt atctcaaatc tgatgggaaa atagctgaaa aagaatgggt ctacgattct   960
catagtcaag cttggtacta cttcaaatcc ggtggttaca tgacagccaa tgaatggatt   1020
tgggataagg aatcttggtt ttacctcaaa tctgatggga aaatagctga aaaagaatgg   1080
gtctacgatt ctcatagtca agcttggtac tacttcaaat ctggtggcta catggcgaaa   1140
aatgagacag tagatggtta tcagcttgga agcgatggta aatggcttgg aggaaaaact   1200
acaaatgaaa atgctgctta ctatcaagta gtgcctgtta cagccaatgt ttatgattca   1260
gatggtgaaa agctttccta tatatcgcaa ggtagtgtcg tatggctaga taaggataga   1320
aaaagtgatg acaagcgctt ggctattact atttctggtt tgtcaggcta tatgaaaaca   1380
gaagatttac aagcgctaga tgctagtaag gactttatcc cttattatga gagtgatggc   1440
caccgttttt atcactatgt ggctcagaat gctagtatcc cagtagcttc tcatctttct   1500
gatatggaag taggcaagaa atattattcg gcagatggcc tgcattttga tggttttaag   1560
cttgagaatc ccttcctttt caaagattta acagaggcta caaactacag tgctgaagaa   1620
ttggataagg tatttagttt gctaaacatt aacaatagcc ttttggagaa caagggcgct   1680
acttttaagg aagccgaaga acattaccat atcaatgctc tttatctcct tgcccatagt   1740
gccctagaaa gtaactgggg aagaagtaaa attgccaaag ataagaataa tttctttggc   1800
attacagcct atgatacgac cccttacctt tctgctaaga catttgatga tgtggataag   1860
ggaattttag gtgcaaccaa gtggattaag gaaaattata tcgatagggg aagaactttc   1920
cttggaaaca aggcttctgg tatgaatgtg gaatatgctt cagaccctta ttggggcgaa   1980
aaaattgcta gtgtgatgat gaaaatcaat gagaagctag gtggcaaaga t            2031

<210>   1902
<211>   677
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   endo-beta-N-acetylglucosaminidase (lytB)
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15902911 (0.E+01)

<400>   1902
Met Asn Leu Gly Glu Phe Trp Tyr Asn Lys Ile Asn Lys Asn Arg Gly 
1               5                   10                  15      

Arg Arg Leu Met Lys Lys Val Arg Phe Ile Phe Leu Ala Leu Leu Phe 
            20                  25                  30          

Phe Leu Ala Ser Pro Glu Gly Ala Met Ala Ser Asp Gly Thr Trp Gln 
        35                  40                  45              

Gly Lys Gln Tyr Leu Lys Glu Asp Gly Ser Gln Ala Ala Asn Glu Trp 
    50                  55                  60                  

Val Phe Asp Thr His Tyr Gln Ser Trp Phe Tyr Ile Lys Ala Asp Ala 
65                  70                  75                  80  

Asn Tyr Ala Glu Asn Glu Trp Leu Lys Gln Gly Asp Asp Tyr Phe Tyr 
                85                  90                  95      

Leu Lys Ser Gly Gly Tyr Met Ala Lys Ser Glu Trp Val Glu Asp Lys 
            100                 105                 110         

Gly Ala Phe Tyr Tyr Leu Asp Gln Asp Gly Lys Met Lys Arg Asn Ala 
        115                 120                 125             

Trp Val Gly Thr Ser Tyr Val Gly Ala Thr Gly Ala Lys Val Ile Glu 
    130                 135                 140                 

Asp Trp Val Tyr Asp Ser Gln Tyr Asp Ala Trp Phe Tyr Ile Lys Ala 
145                 150                 155                 160 

Asp Gly Gln His Ala Glu Lys Glu Trp Leu Gln Ile Lys Gly Lys Asp 
                165                 170                 175     

Tyr Tyr Phe Lys Ser Gly Gly Tyr Leu Leu Thr Ser Gln Trp Ile Asn 
            180                 185                 190         

Gln Ala Tyr Val Asn Ala Ser Gly Ala Lys Val Gln Gln Gly Trp Leu 
        195                 200                 205             

Phe Asp Lys Gln Tyr Gln Ser Trp Phe Tyr Ile Lys Glu Asn Gly Asn 
    210                 215                 220                 

Tyr Ala Asp Lys Glu Trp Ile Phe Glu Asn Gly His Tyr Tyr Tyr Leu 
225                 230                 235                 240 

Lys Ser Gly Gly Tyr Met Ala Ala Asn Glu Trp Ile Trp Asp Lys Glu 
                245                 250                 255     

Ser Trp Phe Tyr Leu Lys Phe Asp Gly Lys Met Ala Glu Lys Glu Trp 
            260                 265                 270         

Val Tyr Asp Ser His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly 
        275                 280                 285             

Tyr Met Thr Ala Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr 
    290                 295                 300                 

Leu Lys Ser Asp Gly Lys Ile Ala Glu Lys Glu Trp Val Tyr Asp Ser 
305                 310                 315                 320 

His Ser Gln Ala Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Thr Ala 
                325                 330                 335     

Asn Glu Trp Ile Trp Asp Lys Glu Ser Trp Phe Tyr Leu Lys Ser Asp 
            340                 345                 350         

Gly Lys Ile Ala Glu Lys Glu Trp Val Tyr Asp Ser His Ser Gln Ala 
        355                 360                 365             

Trp Tyr Tyr Phe Lys Ser Gly Gly Tyr Met Ala Lys Asn Glu Thr Val 
    370                 375                 380                 

Asp Gly Tyr Gln Leu Gly Ser Asp Gly Lys Trp Leu Gly Gly Lys Thr 
385                 390                 395                 400 

Thr Asn Glu Asn Ala Ala Tyr Tyr Gln Val Val Pro Val Thr Ala Asn 
                405                 410                 415     

Val Tyr Asp Ser Asp Gly Glu Lys Leu Ser Tyr Ile Ser Gln Gly Ser 
            420                 425                 430         

Val Val Trp Leu Asp Lys Asp Arg Lys Ser Asp Asp Lys Arg Leu Ala 
        435                 440                 445             


Ile Thr Ile Ser Gly Leu Ser Gly Tyr Met Lys Thr Glu Asp Leu Gln 
    450                 455                 460                 

Ala Leu Asp Ala Ser Lys Asp Phe Ile Pro Tyr Tyr Glu Ser Asp Gly 
465                 470                 475                 480 

His Arg Phe Tyr His Tyr Val Ala Gln Asn Ala Ser Ile Pro Val Ala 
                485                 490                 495     

Ser His Leu Ser Asp Met Glu Val Gly Lys Lys Tyr Tyr Ser Ala Asp 
            500                 505                 510         

Gly Leu His Phe Asp Gly Phe Lys Leu Glu Asn Pro Phe Leu Phe Lys 
        515                 520                 525             

Asp Leu Thr Glu Ala Thr Asn Tyr Ser Ala Glu Glu Leu Asp Lys Val 
    530                 535                 540                 

Phe Ser Leu Leu Asn Ile Asn Asn Ser Leu Leu Glu Asn Lys Gly Ala 
545                 550                 555                 560 

Thr Phe Lys Glu Ala Glu Glu His Tyr His Ile Asn Ala Leu Tyr Leu 
                565                 570                 575     

Leu Ala His Ser Ala Leu Glu Ser Asn Trp Gly Arg Ser Lys Ile Ala 
            580                 585                 590         

Lys Asp Lys Asn Asn Phe Phe Gly Ile Thr Ala Tyr Asp Thr Thr Pro 
        595                 600                 605             

Tyr Leu Ser Ala Lys Thr Phe Asp Asp Val Asp Lys Gly Ile Leu Gly 
    610                 615                 620                 

Ala Thr Lys Trp Ile Lys Glu Asn Tyr Ile Asp Arg Gly Arg Thr Phe 
625                 630                 635                 640 

Leu Gly Asn Lys Ala Ser Gly Met Asn Val Glu Tyr Ala Ser Asp Pro 
                645                 650                 655     

Tyr Trp Gly Glu Lys Ile Ala Ser Val Met Met Lys Ile Asn Glu Lys 
            660                 665                 670         

Leu Gly Gly Lys Asp 
        675         

<210>   1903
<211>   1680
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1903
atggaataca atcacaagga gagaacgatg tcatttgacg gatttttttt acaccacata   60
gttgaggaat tgcgaagcga attagtgaat ggtcgcatcc agaaaatcaa tcagcctttt   120
gaacaagagt tggtcttgca aatccgcagc aatcgccaaa gccatcgcct gctcctttct   180
gcccatccag tttttggacg cattcagctg acccaaacga cttttgaaaa tccagctcaa   240
ccttctacct ttatcatggt tttgagaaag tatttgcagg gggccctgat tgagtcgatt   300
gagcaagtgg aaaatgaccg tattgtggaa attacagttt ccaataaaaa cgagattgga   360
gaccatatcc aggctacctt gattatcgaa attatgggga aacacagtaa tattctactg   420
gtcgataaaa gcagtcataa aatcctcgaa gttatcaaac acgtcggctt ttcacaaaat   480
agctaccgca ccttacttcc aggatcgacc tatatcgctc cgccaagtac aaaatctctc   540
aatcctttta ctatcaagga tgaaaagctc tttgaaatcc tgcaaaccca agaactaaca   600
gcaaaaaatc ttcaaagcct ctttcaaggt ctgggacgcg atacggcaaa tgaattggaa   660
aggatactgg ttagtgaaaa actttccgct ttccgaaatt ttttcaatca agaaaccaag   720
ccatgcttga ctgagacttc cttcagtcca gttccttttg caaatcaggt gggagagcct   780
tttgcaaatc tttctgattt gttggacacc tactataagg ataaggctga gcgcgaccgc   840
gtcaaacagc aggccagtga actgattcgt cgtgttgaaa atgaacttca gaaaaaccga   900
cacaaactca aaaaacagga aaaagagtta ctggcgacag acaacgctga agaatttcgt   960
caaaaaggag aattgctgac aaccttcctc caccaagtgc ctaacgacca agaccaggtt   1020
atcctagaca actactatac caaccaacct atcatgattg cgcttgataa ggctctgact   1080
cccaaccaga atgcccaacg ctattttaaa cggtatcaga aactcaaaga agctgtcaaa   1140
tacttgactg atttgattga agaaaccaaa gccactattc tctatctgga aagtgtagaa   1200
accgtcctca accaagctgg actggaagaa atcgctgaaa tccgtgaaga attgattcaa   1260
acaggtttta tccgcagaag acaacgggag aaaatccaga aacgcaaaaa actagaacaa   1320
tatctagcaa gcgatggcaa aaccatcatc tatgtcggac gaaacaatct tcaaaatgag   1380
gaattgacct ttaaaatggc ccgcaaggag gaactttggt tccatgctaa ggacattcct   1440
ggaagccatg ttgtcatctc aggaaatctt gacccatctg atgcagtcaa gacagacgca   1500
gcagagttag ctgcctactt ctctcaaggg cgcctgtcga atctggtgca ggtagatatg   1560
attgaagtca aaaaactcaa taaaccaact ggtggaaaac ccggctttgt cacttacaca   1620
ggacaaaaga ccctccgcgt cacaccagac tccaaaaaaa ttgcatccat gaaaaaatcc   1680

<210>   1904
<211>   560
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   adherence and virulence protein A (pavA)
<223>   Cellular location: cytoplasm
<223>   Feature of note: implicated in virulence
<223>   Similar to strain R6 sequence 15902912 (0.E+01)

<400>   1904
Met Glu Tyr Asn His Lys Glu Arg Thr Met Ser Phe Asp Gly Phe Phe 
1               5                   10                  15      

Leu His His Ile Val Glu Glu Leu Arg Ser Glu Leu Val Asn Gly Arg 
            20                  25                  30          

Ile Gln Lys Ile Asn Gln Pro Phe Glu Gln Glu Leu Val Leu Gln Ile 
        35                  40                  45              

Arg Ser Asn Arg Gln Ser His Arg Leu Leu Leu Ser Ala His Pro Val 
    50                  55                  60                  

Phe Gly Arg Ile Gln Leu Thr Gln Thr Thr Phe Glu Asn Pro Ala Gln 
65                  70                  75                  80  

Pro Ser Thr Phe Ile Met Val Leu Arg Lys Tyr Leu Gln Gly Ala Leu 
                85                  90                  95      

Ile Glu Ser Ile Glu Gln Val Glu Asn Asp Arg Ile Val Glu Ile Thr 
            100                 105                 110         

Val Ser Asn Lys Asn Glu Ile Gly Asp His Ile Gln Ala Thr Leu Ile 
        115                 120                 125             

Ile Glu Ile Met Gly Lys His Ser Asn Ile Leu Leu Val Asp Lys Ser 
    130                 135                 140                 

Ser His Lys Ile Leu Glu Val Ile Lys His Val Gly Phe Ser Gln Asn 
145                 150                 155                 160 

Ser Tyr Arg Thr Leu Leu Pro Gly Ser Thr Tyr Ile Ala Pro Pro Ser 
                165                 170                 175     

Thr Lys Ser Leu Asn Pro Phe Thr Ile Lys Asp Glu Lys Leu Phe Glu 
            180                 185                 190         

Ile Leu Gln Thr Gln Glu Leu Thr Ala Lys Asn Leu Gln Ser Leu Phe 
        195                 200                 205             

Gln Gly Leu Gly Arg Asp Thr Ala Asn Glu Leu Glu Arg Ile Leu Val 
    210                 215                 220                 

Ser Glu Lys Leu Ser Ala Phe Arg Asn Phe Phe Asn Gln Glu Thr Lys 
225                 230                 235                 240 

Pro Cys Leu Thr Glu Thr Ser Phe Ser Pro Val Pro Phe Ala Asn Gln 
                245                 250                 255     

Val Gly Glu Pro Phe Ala Asn Leu Ser Asp Leu Leu Asp Thr Tyr Tyr 
            260                 265                 270         

Lys Asp Lys Ala Glu Arg Asp Arg Val Lys Gln Gln Ala Ser Glu Leu 
        275                 280                 285             

Ile Arg Arg Val Glu Asn Glu Leu Gln Lys Asn Arg His Lys Leu Lys 
    290                 295                 300                 

Lys Gln Glu Lys Glu Leu Leu Ala Thr Asp Asn Ala Glu Glu Phe Arg 
305                 310                 315                 320 

Gln Lys Gly Glu Leu Leu Thr Thr Phe Leu His Gln Val Pro Asn Asp 
                325                 330                 335     

Gln Asp Gln Val Ile Leu Asp Asn Tyr Tyr Thr Asn Gln Pro Ile Met 
            340                 345                 350         

Ile Ala Leu Asp Lys Ala Leu Thr Pro Asn Gln Asn Ala Gln Arg Tyr 
        355                 360                 365             

Phe Lys Arg Tyr Gln Lys Leu Lys Glu Ala Val Lys Tyr Leu Thr Asp 
    370                 375                 380                 

Leu Ile Glu Glu Thr Lys Ala Thr Ile Leu Tyr Leu Glu Ser Val Glu 
385                 390                 395                 400 

Thr Val Leu Asn Gln Ala Gly Leu Glu Glu Ile Ala Glu Ile Arg Glu 
                405                 410                 415     

Glu Leu Ile Gln Thr Gly Phe Ile Arg Arg Arg Gln Arg Glu Lys Ile 
            420                 425                 430         

Gln Lys Arg Lys Lys Leu Glu Gln Tyr Leu Ala Ser Asp Gly Lys Thr 
        435                 440                 445             

Ile Ile Tyr Val Gly Arg Asn Asn Leu Gln Asn Glu Glu Leu Thr Phe 
    450                 455                 460                 

Lys Met Ala Arg Lys Glu Glu Leu Trp Phe His Ala Lys Asp Ile Pro 
465                 470                 475                 480 

Gly Ser His Val Val Ile Ser Gly Asn Leu Asp Pro Ser Asp Ala Val 
                485                 490                 495     

Lys Thr Asp Ala Ala Glu Leu Ala Ala Tyr Phe Ser Gln Gly Arg Leu 
            500                 505                 510         

Ser Asn Leu Val Gln Val Asp Met Ile Glu Val Lys Lys Leu Asn Lys 
        515                 520                 525             

Pro Thr Gly Gly Lys Pro Gly Phe Val Thr Tyr Thr Gly Gln Lys Thr 
    530                 535                 540                 

Leu Arg Val Thr Pro Asp Ser Lys Lys Ile Ala Ser Met Lys Lys Ser 
545                 550                 555                 560 


<210>   1905
<211>   495
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1905
atgtatattg aaatggtaga tgaaactggt caagtttcaa aagaaatgtt gcaacaaacc   60
caagaaattt tggaatttgc agcccaaaaa ttaggaaaag aagacaagga gatggcagtc   120
acttttgtga ccaatgagcg tagtcatgaa cttaatctgg agtaccgtaa caccgaccgt   180
ccgacagatg tcatcagcct tgagtataaa ccagaattgg aaattgcctt tgacgaagag   240
gatttgcttg aaaattcaga attggcagag atgatgtctg agtttgatgc ctatattggg   300
gaattgttca tctctatcga taaggctcat gagcaggccg aagaatatgg tcacagcttt   360
gagcgtgaga tgggcttctt ggcagtacac ggctttttac atattaacgg ctatgatcac   420
tacactccgg aagaagaagc ggagatgttc ggtttacaag aagaaatttt gacagcctat   480
ggactcacaa gacaa                                                    495

<210>   1906
<211>   165
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein TIGR00043
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902913 (2.E-91)

<400>   1906
Met Tyr Ile Glu Met Val Asp Glu Thr Gly Gln Val Ser Lys Glu Met 
1               5                   10                  15      

Leu Gln Gln Thr Gln Glu Ile Leu Glu Phe Ala Ala Gln Lys Leu Gly 
            20                  25                  30          

Lys Glu Asp Lys Glu Met Ala Val Thr Phe Val Thr Asn Glu Arg Ser 
        35                  40                  45              

His Glu Leu Asn Leu Glu Tyr Arg Asn Thr Asp Arg Pro Thr Asp Val 
    50                  55                  60                  

Ile Ser Leu Glu Tyr Lys Pro Glu Leu Glu Ile Ala Phe Asp Glu Glu 
65                  70                  75                  80  

Asp Leu Leu Glu Asn Ser Glu Leu Ala Glu Met Met Ser Glu Phe Asp 
                85                  90                  95      

Ala Tyr Ile Gly Glu Leu Phe Ile Ser Ile Asp Lys Ala His Glu Gln 
            100                 105                 110         

Ala Glu Glu Tyr Gly His Ser Phe Glu Arg Glu Met Gly Phe Leu Ala 
        115                 120                 125             

Val His Gly Phe Leu His Ile Asn Gly Tyr Asp His Tyr Thr Pro Glu 
    130                 135                 140                 

Glu Glu Ala Glu Met Phe Gly Leu Gln Glu Glu Ile Leu Thr Ala Tyr 
145                 150                 155                 160 

Gly Leu Thr Arg Gln 
                165 

<210>   1907
<211>   393
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1907
atggactcac aagacaataa acgaaaatgg aaaaatcgtg acttgatatc cagtttagaa   60
tttgctttga caggtatttt tactgctatc aaggaagaac gcaatatgcg aaaacacgca   120
gtgacggctc tagtggtcat ccttgcaggt tttgtttttc aggtgtcacg aatcgaatgg   180
ctctttctcc tattgagtat tttcttggta gtagcctttg agattatcaa ctctgctatt   240
gaaaatgtgg tggatttggc cagtcactat cacttttcca tgctggctaa aaatgccaag   300
gatatggcgg ccggcgcggt attagtggtt tctcttttcg cagccttaac aggcgcattg   360
atttttctcc cacgaatctg ggatttatta ttt                                393

<210>   1908
<211>   131
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   diacylglycerol kinase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902914 (3.E-68)

<400>   1908
Met Asp Ser Gln Asp Asn Lys Arg Lys Trp Lys Asn Arg Asp Leu Ile 
1               5                   10                  15      

Ser Ser Leu Glu Phe Ala Leu Thr Gly Ile Phe Thr Ala Ile Lys Glu 
            20                  25                  30          

Glu Arg Asn Met Arg Lys His Ala Val Thr Ala Leu Val Val Ile Leu 
        35                  40                  45              

Ala Gly Phe Val Phe Gln Val Ser Arg Ile Glu Trp Leu Phe Leu Leu 
    50                  55                  60                  

Leu Ser Ile Phe Leu Val Val Ala Phe Glu Ile Ile Asn Ser Ala Ile 
65                  70                  75                  80  

Glu Asn Val Val Asp Leu Ala Ser His Tyr His Phe Ser Met Leu Ala 
                85                  90                  95      

Lys Asn Ala Lys Asp Met Ala Ala Gly Ala Val Leu Val Val Ser Leu 
            100                 105                 110         

Phe Ala Ala Leu Thr Gly Ala Leu Ile Phe Leu Pro Arg Ile Trp Asp 
        115                 120                 125             

Leu Leu Phe 
    130     

<210>   1909
<211>   897
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1909
atgactttta aatcaggctt tgtagccatt ttaggacgtc ccaatgttgg gaagtcaacc   60
tttttaaatc acgttatggg gcaaaagatt gccatcatga gtgacaaggc gcagacaacg   120
cgcaataaaa tcatgggaat ttacacgact gataaggagc aaattgtctt tatcgacaca   180
ccagggattc acaagcctaa aacagctctc ggagatttca tggttgagtc tgcctacagt   240
acccttcgcg aagtggacac tgttcttttc atggtgcctg ctgatgaagc gcgtggtaag   300
ggggacgata tgattatcga gcgtctcaag gctgccaagg ttcctgtgat tttggtggtg   360
aataaaatcg ataaggtcca tccagaccag ctcttgtctc agattgatga cttccgtaat   420
caaatggact ttaaggaaat tgttccaatc tcagcccttc agggaaataa cgtgtctcgt   480
ctagtggata ttttgagtga aaatctggat gaaggtttcc aatatttccc gtctgatcaa   540
atcacagacc atccagaacg tttcttggtt tcagaaatgg ttcgcgagaa agtcttgcac   600
ctaactcgtg aagagattcc gcattctgta gcagtagttg ttgactctat gaaacgagac   660
gaagagacag acaaggttca catccgtgca accatcatgg tcgagcgcga tagccaaaaa   720
gggattatca tcggtaaagg tggcgctatg cttaagaaaa tcggtagcat ggcccgtcgt   780
gatatcgaac tcatgctagg agacaaggtc ttcctagaaa cctgggtcaa ggtcaagaaa   840
aactggcgcg ataaaaagct agatttggct gactttggct ataatgaaag agaatac      897

<210>   1910
<211>   299
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP-binding protein Era (era)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902915 (e-170)

<400>   1910
Met Thr Phe Lys Ser Gly Phe Val Ala Ile Leu Gly Arg Pro Asn Val 
1               5                   10                  15      

Gly Lys Ser Thr Phe Leu Asn His Val Met Gly Gln Lys Ile Ala Ile 
            20                  25                  30          

Met Ser Asp Lys Ala Gln Thr Thr Arg Asn Lys Ile Met Gly Ile Tyr 
        35                  40                  45              

Thr Thr Asp Lys Glu Gln Ile Val Phe Ile Asp Thr Pro Gly Ile His 
    50                  55                  60                  

Lys Pro Lys Thr Ala Leu Gly Asp Phe Met Val Glu Ser Ala Tyr Ser 
65                  70                  75                  80  

Thr Leu Arg Glu Val Asp Thr Val Leu Phe Met Val Pro Ala Asp Glu 
                85                  90                  95      

Ala Arg Gly Lys Gly Asp Asp Met Ile Ile Glu Arg Leu Lys Ala Ala 
            100                 105                 110         

Lys Val Pro Val Ile Leu Val Val Asn Lys Ile Asp Lys Val His Pro 
        115                 120                 125             

Asp Gln Leu Leu Ser Gln Ile Asp Asp Phe Arg Asn Gln Met Asp Phe 
    130                 135                 140                 

Lys Glu Ile Val Pro Ile Ser Ala Leu Gln Gly Asn Asn Val Ser Arg 
145                 150                 155                 160 

Leu Val Asp Ile Leu Ser Glu Asn Leu Asp Glu Gly Phe Gln Tyr Phe 
                165                 170                 175     

Pro Ser Asp Gln Ile Thr Asp His Pro Glu Arg Phe Leu Val Ser Glu 
            180                 185                 190         

Met Val Arg Glu Lys Val Leu His Leu Thr Arg Glu Glu Ile Pro His 
        195                 200                 205             

Ser Val Ala Val Val Val Asp Ser Met Lys Arg Asp Glu Glu Thr Asp 
    210                 215                 220                 

Lys Val His Ile Arg Ala Thr Ile Met Val Glu Arg Asp Ser Gln Lys 
225                 230                 235                 240 

Gly Ile Ile Ile Gly Lys Gly Gly Ala Met Leu Lys Lys Ile Gly Ser 
                245                 250                 255     

Met Ala Arg Arg Asp Ile Glu Leu Met Leu Gly Asp Lys Val Phe Leu 
            260                 265                 270         

Glu Thr Trp Val Lys Val Lys Lys Asn Trp Arg Asp Lys Lys Leu Asp 
        275                 280                 285             

Leu Ala Asp Phe Gly Tyr Asn Glu Arg Glu Tyr 
    290                 295                 

<210>   1911
<211>   822
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1911
atgcctgaat tacctgaggt tgaaaccgtt tgtcgtggct tagaaaaatt gattatagga   60
aagaagattt cgagtataga aattcgctac cccaagatga ttaagacgga tttggaagag   120
tttcaaaggg aattgcctag tcagattatc gagtcaatgg gacgtcgtgg aaaatatttg   180
cttttttatc tgacagacaa ggtcttgatt tcccatttgc ggatggaggg caagtatttt   240
tactatccag accaaggacc tgaacgcaag catgcccatg ttttctttca ttttgaagat   300
ggtggcacgc ttgtttatga ggatgttcgc aagtttggaa ccatggaact cttggtgcct   360
gaccttttag acgtctactt tatttctaaa aaattaggtc ctgaaccaag cgaacaagac   420
tttgatttac aggtctttca atctgccctt gccaagtcca aaaagcctat caaatcccat   480
ctcctagacc agaccttggt agctggactt ggcaatatct atgtggatga ggttctctgg   540
cgagctcagg ttcatccagc tagaccttcc cagactttga cagcagaaga agcgactgcc   600
attcatgacc agaccattgc tgttttgggc caggctgttg aaaaaggtgg ctccaccatt   660
cggacttata ccaatgcctt tggggaagat ggaagcatgc aggactttca tcaggtctat   720
gataagactg gtcaagaatg tgtacgctgt ggtaccatca ttgagaaaat tcaactaggc   780
ggacgtggaa cccacttttg tccaaactgt caaaggaggg ac                      822

<210>   1912
<211>   274
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   formamidopyrimidine-DNA glycosylase (fpg)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902916 (e-160)

<400>   1912
Met Pro Glu Leu Pro Glu Val Glu Thr Val Cys Arg Gly Leu Glu Lys 
1               5                   10                  15      

Leu Ile Ile Gly Lys Lys Ile Ser Ser Ile Glu Ile Arg Tyr Pro Lys 
            20                  25                  30          

Met Ile Lys Thr Asp Leu Glu Glu Phe Gln Arg Glu Leu Pro Ser Gln 
        35                  40                  45              

Ile Ile Glu Ser Met Gly Arg Arg Gly Lys Tyr Leu Leu Phe Tyr Leu 
    50                  55                  60                  

Thr Asp Lys Val Leu Ile Ser His Leu Arg Met Glu Gly Lys Tyr Phe 
65                  70                  75                  80  

Tyr Tyr Pro Asp Gln Gly Pro Glu Arg Lys His Ala His Val Phe Phe 
                85                  90                  95      

His Phe Glu Asp Gly Gly Thr Leu Val Tyr Glu Asp Val Arg Lys Phe 
            100                 105                 110         

Gly Thr Met Glu Leu Leu Val Pro Asp Leu Leu Asp Val Tyr Phe Ile 
        115                 120                 125             

Ser Lys Lys Leu Gly Pro Glu Pro Ser Glu Gln Asp Phe Asp Leu Gln 
    130                 135                 140                 

Val Phe Gln Ser Ala Leu Ala Lys Ser Lys Lys Pro Ile Lys Ser His 
145                 150                 155                 160 

Leu Leu Asp Gln Thr Leu Val Ala Gly Leu Gly Asn Ile Tyr Val Asp 
                165                 170                 175     

Glu Val Leu Trp Arg Ala Gln Val His Pro Ala Arg Pro Ser Gln Thr 
            180                 185                 190         

Leu Thr Ala Glu Glu Ala Thr Ala Ile His Asp Gln Thr Ile Ala Val 
        195                 200                 205             

Leu Gly Gln Ala Val Glu Lys Gly Gly Ser Thr Ile Arg Thr Tyr Thr 
    210                 215                 220                 

Asn Ala Phe Gly Glu Asp Gly Ser Met Gln Asp Phe His Gln Val Tyr 
225                 230                 235                 240 

Asp Lys Thr Gly Gln Glu Cys Val Arg Cys Gly Thr Ile Ile Glu Lys 
                245                 250                 255     

Ile Gln Leu Gly Gly Arg Gly Thr His Phe Cys Pro Asn Cys Gln Arg 
            260                 265                 270         

Arg Asp 
        

<210>   1913
<211>   552
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1913
gtgacaaatt ttctaagaca gcaaggcttt caagtagtgg atgccgacgc agtcgtccac   60
caactacaga aacctggtgg tcgtctgttt gaggctctag tacagcactt tgggcaagaa   120
atcattcttg aaaacggaga actcaatcgc cctctcctag ctagtctcat cttttcaaat   180
cctgatgaac gagaatggtc taagcaaatt caaggggaga ttatccgtga ggaactggct   240
actttgagag aacagttggc tcagacagaa gagattttct tcatggatat tcccctactt   300
tttgagcagg actacagcga ttggtttgct gagacttggt tggtctatgt ggaccgagat   360
gcccaagtgg aacgcttaat gaaaagggac cagttgtcca aagatgaagc tgagtctcgt   420
ctggcagccc agtggccttt agaaaaaaag aaagatttgg ccagccaggt tcttgataat   480
aatggcaatc agaaccagct tcttaatcaa gtgcatatcc ttcttgaggg aggtaggcaa   540
gatgacagag at                                                       552

<210>   1914
<211>   184
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   kinase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902917 (e-111)

<400>   1914
Met Thr Asn Phe Leu Arg Gln Gln Gly Phe Gln Val Val Asp Ala Asp 
1               5                   10                  15      

Ala Val Val His Gln Leu Gln Lys Pro Gly Gly Arg Leu Phe Glu Ala 
            20                  25                  30          

Leu Val Gln His Phe Gly Gln Glu Ile Ile Leu Glu Asn Gly Glu Leu 
        35                  40                  45              

Asn Arg Pro Leu Leu Ala Ser Leu Ile Phe Ser Asn Pro Asp Glu Arg 
    50                  55                  60                  

Glu Trp Ser Lys Gln Ile Gln Gly Glu Ile Ile Arg Glu Glu Leu Ala 
65                  70                  75                  80  

Thr Leu Arg Glu Gln Leu Ala Gln Thr Glu Glu Ile Phe Phe Met Asp 
                85                  90                  95      

Ile Pro Leu Leu Phe Glu Gln Asp Tyr Ser Asp Trp Phe Ala Glu Thr 
            100                 105                 110         

Trp Leu Val Tyr Val Asp Arg Asp Ala Gln Val Glu Arg Leu Met Lys 
        115                 120                 125             

Arg Asp Gln Leu Ser Lys Asp Glu Ala Glu Ser Arg Leu Ala Ala Gln 
    130                 135                 140                 

Trp Pro Leu Glu Lys Lys Lys Asp Leu Ala Ser Gln Val Leu Asp Asn 
145                 150                 155                 160 

Asn Gly Asn Gln Asn Gln Leu Leu Asn Gln Val His Ile Leu Leu Glu 
                165                 170                 175     

Gly Gly Arg Gln Asp Asp Arg Asp 
            180                 

<210>   1915
<211>   135
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1915
atgcgcagat tatccttcca gttaatctct gtcatcttgc ctacctccct caagaaggat   60
atgcacttga ttaagaagct ggttctgatt gccattatta tcaagaacct ggctggccaa   120
atctttcttt ttttc                                                    135

<210>   1916
<211>   45
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   hypothetical protein

<400>   1916
Met Arg Arg Leu Ser Phe Gln Leu Ile Ser Val Ile Leu Pro Thr Ser 
1               5                   10                  15      

Leu Lys Lys Asp Met His Leu Ile Lys Lys Leu Val Leu Ile Ala Ile 
            20                  25                  30          

Ile Ile Lys Asn Leu Ala Gly Gln Ile Phe Leu Phe Phe 
        35                  40                  45  

<210>   1917
<211>   1122
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1917
ttggttgtac cttttatgcc catcttcgtg gaaaatctag gtgtagggag tcagcaagtc   60
gctttttatg caggcttagc aatttctgtc tctgctattt ccgcggcgct cttttctcct   120
atttggggta ttcttgctga caaatacggc cgaaaaccca tgatgattcg ggcaggtctt   180
gctatgacta tcactatggg aggcttggcc tttgtcccaa atatctattg gttaatcttt   240
cttcgtttac taaacggtgt atttgcaggt tttgttccta atgcaacggc actgatagcc   300
agtcaggttc caaaggagaa atcaggctct gccttaggta ctttgtctac aggcgtagtt   360
gcaggtactc taactggtcc ctttattggt ggctttatcg cagaattatt tggcattcgt   420
acagttttct tactggttgg tagttttcta tttttagctg ctattttgac tatttgcttt   480
atcaaggaag attttcaacc agtagccaag gaaaaggcta ttccaacaaa ggaattattt   540
acctcggtta aatatcccta tcttttgctc aatctctttt taaccagttt tgtcatccaa   600
ttttcagctc aatcgattgg ccctattttg gctctttatg tacgcgactt agggcagaca   660
gagaatcttc tttttgtctc tggtttgatt gtgtccagta tgggcttttc cagcatgatg   720
agtgcaggag tcatgggcaa gctaggtgac aaggtgggca atcatcgtct cttggttgtc   780
gcccagtttt attcagtcat catctatctc ctctgtgcca atgcctctag cccccttcaa   840
ctaggactct atcgtttcct ctttggattg ggaaccggtg ccttgattcc cggggttaat   900
gccctactca gcaaaatgac tcccaaagcc ggcatttcga gggtctttgc cttcaatcag   960
gtattctttt atctgggagg tgttgttggt cccatggcag gttctgcagt agcaggtcaa   1020
tttggctacc atgctgtctt ttatgcgaca agcctttgtg ttgcctttag ttgtctcttt   1080
aacctgattc aatttcgaac attattaaaa gtaaaggaaa tc                      1122

<210>   1918
<211>   374
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   multi-drug resistance efflux pump (pmrA)

<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902919 (0.E+01)

<400>   1918
Met Val Val Pro Phe Met Pro Ile Phe Val Glu Asn Leu Gly Val Gly 
1               5                   10                  15      

Ser Gln Gln Val Ala Phe Tyr Ala Gly Leu Ala Ile Ser Val Ser Ala 
            20                  25                  30          

Ile Ser Ala Ala Leu Phe Ser Pro Ile Trp Gly Ile Leu Ala Asp Lys 
        35                  40                  45              

Tyr Gly Arg Lys Pro Met Met Ile Arg Ala Gly Leu Ala Met Thr Ile 
    50                  55                  60                  

Thr Met Gly Gly Leu Ala Phe Val Pro Asn Ile Tyr Trp Leu Ile Phe 
65                  70                  75                  80  

Leu Arg Leu Leu Asn Gly Val Phe Ala Gly Phe Val Pro Asn Ala Thr 
                85                  90                  95      

Ala Leu Ile Ala Ser Gln Val Pro Lys Glu Lys Ser Gly Ser Ala Leu 
            100                 105                 110         

Gly Thr Leu Ser Thr Gly Val Val Ala Gly Thr Leu Thr Gly Pro Phe 
        115                 120                 125             

Ile Gly Gly Phe Ile Ala Glu Leu Phe Gly Ile Arg Thr Val Phe Leu 
    130                 135                 140                 

Leu Val Gly Ser Phe Leu Phe Leu Ala Ala Ile Leu Thr Ile Cys Phe 
145                 150                 155                 160 

Ile Lys Glu Asp Phe Gln Pro Val Ala Lys Glu Lys Ala Ile Pro Thr 
                165                 170                 175     

Lys Glu Leu Phe Thr Ser Val Lys Tyr Pro Tyr Leu Leu Leu Asn Leu 
            180                 185                 190         

Phe Leu Thr Ser Phe Val Ile Gln Phe Ser Ala Gln Ser Ile Gly Pro 
        195                 200                 205             

Ile Leu Ala Leu Tyr Val Arg Asp Leu Gly Gln Thr Glu Asn Leu Leu 
    210                 215                 220                 

Phe Val Ser Gly Leu Ile Val Ser Ser Met Gly Phe Ser Ser Met Met 
225                 230                 235                 240 

Ser Ala Gly Val Met Gly Lys Leu Gly Asp Lys Val Gly Asn His Arg 
                245                 250                 255     

Leu Leu Val Val Ala Gln Phe Tyr Ser Val Ile Ile Tyr Leu Leu Cys 
            260                 265                 270         

Ala Asn Ala Ser Ser Pro Leu Gln Leu Gly Leu Tyr Arg Phe Leu Phe 
        275                 280                 285             

Gly Leu Gly Thr Gly Ala Leu Ile Pro Gly Val Asn Ala Leu Leu Ser 
    290                 295                 300                 


Lys Met Thr Pro Lys Ala Gly Ile Ser Arg Val Phe Ala Phe Asn Gln 
305                 310                 315                 320 

Val Phe Phe Tyr Leu Gly Gly Val Val Gly Pro Met Ala Gly Ser Ala 
                325                 330                 335     

Val Ala Gly Gln Phe Gly Tyr His Ala Val Phe Tyr Ala Thr Ser Leu 
            340                 345                 350         

Cys Val Ala Phe Ser Cys Leu Phe Asn Leu Ile Gln Phe Arg Thr Leu 
        355                 360                 365             

Leu Lys Val Lys Glu Ile 
    370                 

<210>   1919
<211>   231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1919
atgtataacc tattattaac cattttatta gtattatctg ttgtgattgt gattgcaatt   60
ttcatgcaac caaccaaaaa ccaatccagc aatgtatttg atgccagttc aggtgatttg   120
tttgaacgca gtaaagctcg cggttttgaa gctgtaatgc agcgtttgac agggatttta   180
gtctttttct ggctagccat tgccttagca ttgacggtat tatcaagtag a            231

<210>   1920
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   preprotein translocase, SecG subunit, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902921 (2.E-37)

<400>   1920
Met Tyr Asn Leu Leu Leu Thr Ile Leu Leu Val Leu Ser Val Val Ile 
1               5                   10                  15      

Val Ile Ala Ile Phe Met Gln Pro Thr Lys Asn Gln Ser Ser Asn Val 
            20                  25                  30          

Phe Asp Ala Ser Ser Gly Asp Leu Phe Glu Arg Ser Lys Ala Arg Gly 
        35                  40                  45              

Phe Glu Ala Val Met Gln Arg Leu Thr Gly Ile Leu Val Phe Phe Trp 
    50                  55                  60                  

Leu Ala Ile Ala Leu Ala Leu Thr Val Leu Ser Ser Arg 
65                  70                  75          

<210>   1921
<211>   2352
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1921
atgaaagata gaataaaaga atatttacaa gacaagggaa aggtgactgt taatgatttg   60
gctcaggctt tgggaaaaga cagttccaag gattttcgtg agttgattaa aaccttgtcc   120
ttaatggaaa gaaagcacca aattcgtttt gaagaagatg gtagtctgac attagaaatt   180
aagaaaaaac atgagattac cctcaagggg atttttcatg cccataaaaa tggctttggc   240
tttgttagtc tggaaggcga ggaggacgac ctttttgtag ggaaaaatga tgtcaactat   300
gctattgatg gtgataccgt cgaggtagtg attaagaaag tcgctgaccg caataaggga   360
acagcagcag aagccaaaat tattgatatc ctagaacaca gtttgacaac agttgtcggg   420
caaatcgttc tggatcagga aaaacctaag tatgctggct atattcgttc aaaaaatcag   480
aaaatcagtc aaccgattta tgttaagaaa ccagccctaa aattagaagg aacagaagtt   540
ctcaaagtct ttatcgataa atacccaagc aagaaacatg atttctttgt cgcgagtgtt   600
ctcgatgtag tgggacactc aacggatgtc ggaattgatg ttcttgaggt cttggaatca   660
atggacattg tatccgagtt tccagaagct gttgttaagg aagcagaaag tgtgcctgat   720
gctccgtctc aaaaggatat ggaaggtcgt ctggatctaa gagatgaaat tacctttacc   780
attgacggtg cggatgccaa ggacttggac gatgcagtgc atatcaaggc tctgaaaaat   840
ggcaatctgg agtttggggt tcacatcgca gatgtttctt attatgtgac cgaggggtct   900
gcccttgaca aggaagccct taaccgtgcg acttctgttt acgtgacaga ccgagtggtg   960
ccaatgcttc cagaacgact atcaaatggc atctgctctc tcaatcccca agttgaccgc   1020
ctgacccagt ctgctattat ggagattgat aaacatggtc gtgtggtcaa ctataccatt   1080
acacaaacag ttatcaagac cagttttcgt atgacctata gcgatgtcaa tgatatccta   1140
gctggcgatg aagaaaagag aaaagaatat cataaaattg tatcaagtat cgaactcatg   1200
gccaagcttc atgaaacttt agaaaacatg cgtgtgaaac gtggagctct caattttgat   1260
accaatgaag cgaagatttt agtggataaa caaggtaagc ctgttgatat cgttcttcgg   1320
cagcgtggta ttgccgagcg gatgattgag tcttttatgt tgatggctaa tgaaacagtt   1380
gccgaacatt tcagcaagtt ggatttgcct tttatctatc gaattcacga ggagcctaag   1440
gctgaaaagg ttcagaagtt tattgattat gcttcgagtt ttggcttgcg catttatgga   1500
actgccagtg agattagtca ggaggcactt caagacatca tgcgtgctgt tgagggagaa   1560
ccttatgcag atgtattgtc catgatgctt cttcgctcta tgcagcaggc tcgttattcg   1620
gagcacaatc acggccacta tggactagct gctgactatt atactcactt taccagtcca   1680
attcgtcgtt atccagacct tcttgttcac cgtatgattc gggattacgg ccgttctaag   1740
gaaatagcag agcattttga acaagtgatt ccagagattg cgacccagtc ttccaaccgt   1800
gaacgtcgtg ccatagaagc tgagcgtgaa gtcgaagcca tgaaaaaggc tgagtatatg   1860
gaagaatacg tgggtgaaga gtatgatgca gttgtatcaa gtattgtcaa attcggtctc   1920
tttgtcgaat tgccaaacac agttgaaggc ttgattcaca tcactaatct gcctgaattt   1980
tatcatttca atgagcgtga tttgactctt cgtggagaaa aatcaggtat cactttccga   2040
gtgggtcagc agatccgtat ccgtgttgaa agagcggata aaatgactgg agagattgat   2100
ttttcattcg tacctagtga gtttgatgtg attgaaaaag gcttgaaaca gtctagtcgt   2160
agtggcagag ggcgtgattc aaatcgtcgt tcggataaga aggaagacaa gagaaaatca   2220
ggacgctcaa atgataagcg taagcattca caaaaagaca agaagaaaaa aggaaagaaa   2280
cctttttaca aggaagtagc taagaaagga gccaagcatg gcaaagggcg agggaaaggt   2340
cgtcgcacaa aa                                                       2352

<210>   1922
<211>   784
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   exoribonuclease, VacB/Rnb family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902922 (0.E+01)

<400>   1922
Met Lys Asp Arg Ile Lys Glu Tyr Leu Gln Asp Lys Gly Lys Val Thr 
1               5                   10                  15      

Val Asn Asp Leu Ala Gln Ala Leu Gly Lys Asp Ser Ser Lys Asp Phe 
            20                  25                  30          

Arg Glu Leu Ile Lys Thr Leu Ser Leu Met Glu Arg Lys His Gln Ile 
        35                  40                  45              

Arg Phe Glu Glu Asp Gly Ser Leu Thr Leu Glu Ile Lys Lys Lys His 
    50                  55                  60                  

Glu Ile Thr Leu Lys Gly Ile Phe His Ala His Lys Asn Gly Phe Gly 
65                  70                  75                  80  

Phe Val Ser Leu Glu Gly Glu Glu Asp Asp Leu Phe Val Gly Lys Asn 
                85                  90                  95      

Asp Val Asn Tyr Ala Ile Asp Gly Asp Thr Val Glu Val Val Ile Lys 
            100                 105                 110         


Lys Val Ala Asp Arg Asn Lys Gly Thr Ala Ala Glu Ala Lys Ile Ile 
        115                 120                 125             

Asp Ile Leu Glu His Ser Leu Thr Thr Val Val Gly Gln Ile Val Leu 
    130                 135                 140                 

Asp Gln Glu Lys Pro Lys Tyr Ala Gly Tyr Ile Arg Ser Lys Asn Gln 
145                 150                 155                 160 

Lys Ile Ser Gln Pro Ile Tyr Val Lys Lys Pro Ala Leu Lys Leu Glu 
                165                 170                 175     

Gly Thr Glu Val Leu Lys Val Phe Ile Asp Lys Tyr Pro Ser Lys Lys 
            180                 185                 190         

His Asp Phe Phe Val Ala Ser Val Leu Asp Val Val Gly His Ser Thr 
        195                 200                 205             

Asp Val Gly Ile Asp Val Leu Glu Val Leu Glu Ser Met Asp Ile Val 
    210                 215                 220                 

Ser Glu Phe Pro Glu Ala Val Val Lys Glu Ala Glu Ser Val Pro Asp 
225                 230                 235                 240 

Ala Pro Ser Gln Lys Asp Met Glu Gly Arg Leu Asp Leu Arg Asp Glu 
                245                 250                 255     

Ile Thr Phe Thr Ile Asp Gly Ala Asp Ala Lys Asp Leu Asp Asp Ala 
            260                 265                 270         

Val His Ile Lys Ala Leu Lys Asn Gly Asn Leu Glu Phe Gly Val His 
        275                 280                 285             

Ile Ala Asp Val Ser Tyr Tyr Val Thr Glu Gly Ser Ala Leu Asp Lys 
    290                 295                 300                 

Glu Ala Leu Asn Arg Ala Thr Ser Val Tyr Val Thr Asp Arg Val Val 
305                 310                 315                 320 

Pro Met Leu Pro Glu Arg Leu Ser Asn Gly Ile Cys Ser Leu Asn Pro 
                325                 330                 335     

Gln Val Asp Arg Leu Thr Gln Ser Ala Ile Met Glu Ile Asp Lys His 
            340                 345                 350         

Gly Arg Val Val Asn Tyr Thr Ile Thr Gln Thr Val Ile Lys Thr Ser 
        355                 360                 365             

Phe Arg Met Thr Tyr Ser Asp Val Asn Asp Ile Leu Ala Gly Asp Glu 
    370                 375                 380                 

Glu Lys Arg Lys Glu Tyr His Lys Ile Val Ser Ser Ile Glu Leu Met 
385                 390                 395                 400 

Ala Lys Leu His Glu Thr Leu Glu Asn Met Arg Val Lys Arg Gly Ala 
                405                 410                 415     

Leu Asn Phe Asp Thr Asn Glu Ala Lys Ile Leu Val Asp Lys Gln Gly 
            420                 425                 430         

Lys Pro Val Asp Ile Val Leu Arg Gln Arg Gly Ile Ala Glu Arg Met 
        435                 440                 445             


Ile Glu Ser Phe Met Leu Met Ala Asn Glu Thr Val Ala Glu His Phe 
    450                 455                 460                 

Ser Lys Leu Asp Leu Pro Phe Ile Tyr Arg Ile His Glu Glu Pro Lys 
465                 470                 475                 480 

Ala Glu Lys Val Gln Lys Phe Ile Asp Tyr Ala Ser Ser Phe Gly Leu 
                485                 490                 495     

Arg Ile Tyr Gly Thr Ala Ser Glu Ile Ser Gln Glu Ala Leu Gln Asp 
            500                 505                 510         

Ile Met Arg Ala Val Glu Gly Glu Pro Tyr Ala Asp Val Leu Ser Met 
        515                 520                 525             

Met Leu Leu Arg Ser Met Gln Gln Ala Arg Tyr Ser Glu His Asn His 
    530                 535                 540                 

Gly His Tyr Gly Leu Ala Ala Asp Tyr Tyr Thr His Phe Thr Ser Pro 
545                 550                 555                 560 

Ile Arg Arg Tyr Pro Asp Leu Leu Val His Arg Met Ile Arg Asp Tyr 
                565                 570                 575     

Gly Arg Ser Lys Glu Ile Ala Glu His Phe Glu Gln Val Ile Pro Glu 
            580                 585                 590         

Ile Ala Thr Gln Ser Ser Asn Arg Glu Arg Arg Ala Ile Glu Ala Glu 
        595                 600                 605             

Arg Glu Val Glu Ala Met Lys Lys Ala Glu Tyr Met Glu Glu Tyr Val 
    610                 615                 620                 

Gly Glu Glu Tyr Asp Ala Val Val Ser Ser Ile Val Lys Phe Gly Leu 
625                 630                 635                 640 

Phe Val Glu Leu Pro Asn Thr Val Glu Gly Leu Ile His Ile Thr Asn 
                645                 650                 655     

Leu Pro Glu Phe Tyr His Phe Asn Glu Arg Asp Leu Thr Leu Arg Gly 
            660                 665                 670         

Glu Lys Ser Gly Ile Thr Phe Arg Val Gly Gln Gln Ile Arg Ile Arg 
        675                 680                 685             

Val Glu Arg Ala Asp Lys Met Thr Gly Glu Ile Asp Phe Ser Phe Val 
    690                 695                 700                 

Pro Ser Glu Phe Asp Val Ile Glu Lys Gly Leu Lys Gln Ser Ser Arg 
705                 710                 715                 720 

Ser Gly Arg Gly Arg Asp Ser Asn Arg Arg Ser Asp Lys Lys Glu Asp 
                725                 730                 735     

Lys Arg Lys Ser Gly Arg Ser Asn Asp Lys Arg Lys His Ser Gln Lys 
            740                 745                 750         

Asp Lys Lys Lys Lys Gly Lys Lys Pro Phe Tyr Lys Glu Val Ala Lys 
        755                 760                 765             

Lys Gly Ala Lys His Gly Lys Gly Arg Gly Lys Gly Arg Arg Thr Lys 
    770                 775                 780                 



<210>   1923
<211>   465
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1923
atggcaaagg gcgagggaaa ggtcgtcgca caaaataaaa aggcacgcca cgactataca   60
atcgtagata cgctagaggc agggatggtc ctgactggaa ctgaaatcaa gagtgtacga   120
gctgctcgaa ttaatctcaa ggatggcttt gctcaagtga aaaatggaga agtttggctg   180
agcaatgttc atatcgcgcc ttacgaagag ggcaatatct ggaaccagga accagaacgt   240
cgtcgtaaac tcctgctcca taaaaagcaa attcaaaaat tggaacaaga gatcaaaggg   300
acaggaatga ccttagttcc ccttaaggtc tatataaaag atggctacgc taagcttctt   360
ttaggacttg ccaaagggaa gcatgactat gacaaacggg agtctatcaa acgtcgtgag   420
caaaatcgag atatcgcgcg tgtgatgaaa gctgttaatc agcga                   465

<210>   1924
<211>   155
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SsrA-binding protein (smpB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902923 (1.E-85)

<400>   1924
Met Ala Lys Gly Glu Gly Lys Val Val Ala Gln Asn Lys Lys Ala Arg 
1               5                   10                  15      

His Asp Tyr Thr Ile Val Asp Thr Leu Glu Ala Gly Met Val Leu Thr 
            20                  25                  30          

Gly Thr Glu Ile Lys Ser Val Arg Ala Ala Arg Ile Asn Leu Lys Asp 
        35                  40                  45              

Gly Phe Ala Gln Val Lys Asn Gly Glu Val Trp Leu Ser Asn Val His 
    50                  55                  60                  

Ile Ala Pro Tyr Glu Glu Gly Asn Ile Trp Asn Gln Glu Pro Glu Arg 
65                  70                  75                  80  

Arg Arg Lys Leu Leu Leu His Lys Lys Gln Ile Gln Lys Leu Glu Gln 
                85                  90                  95      

Glu Ile Lys Gly Thr Gly Met Thr Leu Val Pro Leu Lys Val Tyr Ile 
            100                 105                 110         

Lys Asp Gly Tyr Ala Lys Leu Leu Leu Gly Leu Ala Lys Gly Lys His 
        115                 120                 125             

Asp Tyr Asp Lys Arg Glu Ser Ile Lys Arg Arg Glu Gln Asn Arg Asp 
    130                 135                 140                 

Ile Ala Arg Val Met Lys Ala Val Asn Gln Arg 
145                 150                 155 

<210>   1925
<211>   864
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1925
ttgaaaatgg aaaaattagt tgcctataaa cgcatgcctt tgtggaataa acaaacaatg   60
cctgaagctg ttcagcaaaa gcacaataca aaagttggga cttgggggaa aattactgtc   120
ttgaagggag ctctcaagtt tattgaattg acagaagaag gggaagttct agctgaacac   180
ctctttgaag caggggcaga caatccaatg gcccaacctc aagcctggca ccgagtggaa   240
gctgccacag atgatgtgga atggtacttg gaattttatt gtaaacctga ggattatttt   300
gctaaaaaat acaataccaa tcctgttcat tcagaggtcc tagaggccat gcagacagtg   360
aaacaaggga aagctttgga tttgggttgt ggtcaggggc gtaattctct ttttctagcc   420
cagcaagatt ttgatgtgac ggctgtagat caaaatggac tagctcttga aatcttgcaa   480
agcattgtgg agcaggaaga tttggacatg cctgttggcc tttacgatat caattcagct   540
agcattgaac aagaatatga ttttatcgtt tcaacagttg ttctcatgtt tctacaagcg   600
gaccgcattc cagctattat tcaaaatatg caggagaaaa ccagtgttgg tggttacaac   660
cttatcgttt gtgccatgga cacggaggat tatccttgct cggttaactt cccattcacc   720
tttaaagaag gagaactggc agactattac aaggattggg aattggttaa gtacaatgaa   780
aatccaggcc atttgcaccg tcgcgatgag aatggcaatc gtattcaact acgctttgcg   840
accttactag ctaagaaaat caag                                          864

<210>   1926
<211>   288
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tellurite resistance protein TehB (tehB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902924 (e-169)

<400>   1926
Met Lys Met Glu Lys Leu Val Ala Tyr Lys Arg Met Pro Leu Trp Asn 
1               5                   10                  15      

Lys Gln Thr Met Pro Glu Ala Val Gln Gln Lys His Asn Thr Lys Val 
            20                  25                  30          

Gly Thr Trp Gly Lys Ile Thr Val Leu Lys Gly Ala Leu Lys Phe Ile 
        35                  40                  45              

Glu Leu Thr Glu Glu Gly Glu Val Leu Ala Glu His Leu Phe Glu Ala 
    50                  55                  60                  

Gly Ala Asp Asn Pro Met Ala Gln Pro Gln Ala Trp His Arg Val Glu 
65                  70                  75                  80  

Ala Ala Thr Asp Asp Val Glu Trp Tyr Leu Glu Phe Tyr Cys Lys Pro 
                85                  90                  95      

Glu Asp Tyr Phe Ala Lys Lys Tyr Asn Thr Asn Pro Val His Ser Glu 
            100                 105                 110         

Val Leu Glu Ala Met Gln Thr Val Lys Gln Gly Lys Ala Leu Asp Leu 
        115                 120                 125             

Gly Cys Gly Gln Gly Arg Asn Ser Leu Phe Leu Ala Gln Gln Asp Phe 
    130                 135                 140                 

Asp Val Thr Ala Val Asp Gln Asn Gly Leu Ala Leu Glu Ile Leu Gln 
145                 150                 155                 160 

Ser Ile Val Glu Gln Glu Asp Leu Asp Met Pro Val Gly Leu Tyr Asp 
                165                 170                 175     

Ile Asn Ser Ala Ser Ile Glu Gln Glu Tyr Asp Phe Ile Val Ser Thr 
            180                 185                 190         

Val Val Leu Met Phe Leu Gln Ala Asp Arg Ile Pro Ala Ile Ile Gln 

        195                 200                 205             

Asn Met Gln Glu Lys Thr Ser Val Gly Gly Tyr Asn Leu Ile Val Cys 
    210                 215                 220                 

Ala Met Asp Thr Glu Asp Tyr Pro Cys Ser Val Asn Phe Pro Phe Thr 
225                 230                 235                 240 

Phe Lys Glu Gly Glu Leu Ala Asp Tyr Tyr Lys Asp Trp Glu Leu Val 
                245                 250                 255     

Lys Tyr Asn Glu Asn Pro Gly His Leu His Arg Arg Asp Glu Asn Gly 
            260                 265                 270         

Asn Arg Ile Gln Leu Arg Phe Ala Thr Leu Leu Ala Lys Lys Ile Lys 
        275                 280                 285             


<210>   1927
<211>   951
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1927
atgtttgttg cgagagatgc taggggagaa ttggtaaatg tgttagagga taaacttgag   60
aagcaagcat acacctgccc agcttgtgga ggccagctcc atttgcgtca aggaccaagt   120
gtacggacgc attttgccca taaatcctta aaagactgtg attttttctt tgaaaatgaa   180
agtccagaac acctggccaa taaggaatcc ctctatcact ggttgaaaaa agagacaaag   240
gttcaattag agtacccgct ttcagaactt aaacagattg cggatgtatt tgtaaatggc   300
aatctagctc tagaagttca gtgtagtccc ttgcctcaga aagtccttaa agagcgaagt   360
gagggctatc gtagtcaggg ttaccaagta ctgtggttgc tgggtcaaaa actgtggctc   420
aaggagcgtt tgactcgtct acagcaaggt tttctttatt tcagtcaaaa catgggcttt   480
tatgtttggg aattagacaa ggaaaaacaa gttttaagac tcaaatacct gatttaccag   540
gatctccgcg gtaaactcca ttatcaaatc aaggaatttt cctatggtca aggtagttta   600
ttggaaatat tgcgtcttcc ctataagaga caaaaaatat ctcattttac agtttctgag   660
gacaaggaca tctgtcgcta tatccggcaa caactttatt atcaaaatct cttttggatg   720
aaagaacaag cagaagccta tcaaaaggga gaaaatatcc tgacttatgg actgaaagaa   780
tggtatccac aaattcgacc aatagtgggc aaatttttcc agattgaaca agacttgact   840
agctattatc agcactttta tacctattac caaaaaaatc ctcaaaatga ttggcaaaag   900
ctttatccac cagcctttta tcagcaatat ttcttgaaaa atatggtaga a            951

<210>   1928
<211>   317
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence protein CoiA (coiA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902925 (0.E+01)

<400>   1928
Met Phe Val Ala Arg Asp Ala Arg Gly Glu Leu Val Asn Val Leu Glu 
1               5                   10                  15      

Asp Lys Leu Glu Lys Gln Ala Tyr Thr Cys Pro Ala Cys Gly Gly Gln 
            20                  25                  30          

Leu His Leu Arg Gln Gly Pro Ser Val Arg Thr His Phe Ala His Lys 
        35                  40                  45              

Ser Leu Lys Asp Cys Asp Phe Phe Phe Glu Asn Glu Ser Pro Glu His 
    50                  55                  60                  

Leu Ala Asn Lys Glu Ser Leu Tyr His Trp Leu Lys Lys Glu Thr Lys 
65                  70                  75                  80  

Val Gln Leu Glu Tyr Pro Leu Ser Glu Leu Lys Gln Ile Ala Asp Val 
                85                  90                  95      

Phe Val Asn Gly Asn Leu Ala Leu Glu Val Gln Cys Ser Pro Leu Pro 
            100                 105                 110         

Gln Lys Val Leu Lys Glu Arg Ser Glu Gly Tyr Arg Ser Gln Gly Tyr 
        115                 120                 125             

Gln Val Leu Trp Leu Leu Gly Gln Lys Leu Trp Leu Lys Glu Arg Leu 
    130                 135                 140                 

Thr Arg Leu Gln Gln Gly Phe Leu Tyr Phe Ser Gln Asn Met Gly Phe 
145                 150                 155                 160 

Tyr Val Trp Glu Leu Asp Lys Glu Lys Gln Val Leu Arg Leu Lys Tyr 
                165                 170                 175     

Leu Ile Tyr Gln Asp Leu Arg Gly Lys Leu His Tyr Gln Ile Lys Glu 
            180                 185                 190         

Phe Ser Tyr Gly Gln Gly Ser Leu Leu Glu Ile Leu Arg Leu Pro Tyr 
        195                 200                 205             

Lys Arg Gln Lys Ile Ser His Phe Thr Val Ser Glu Asp Lys Asp Ile 
    210                 215                 220                 

Cys Arg Tyr Ile Arg Gln Gln Leu Tyr Tyr Gln Asn Leu Phe Trp Met 
225                 230                 235                 240 

Lys Glu Gln Ala Glu Ala Tyr Gln Lys Gly Glu Asn Ile Leu Thr Tyr 
                245                 250                 255     

Gly Leu Lys Glu Trp Tyr Pro Gln Ile Arg Pro Ile Val Gly Lys Phe 
            260                 265                 270         

Phe Gln Ile Glu Gln Asp Leu Thr Ser Tyr Tyr Gln His Phe Tyr Thr 
        275                 280                 285             

Tyr Tyr Gln Lys Asn Pro Gln Asn Asp Trp Gln Lys Leu Tyr Pro Pro 
    290                 295                 300                 

Ala Phe Tyr Gln Gln Tyr Phe Leu Lys Asn Met Val Glu 
305                 310                 315         

<210>   1929
<211>   1800
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1929
atggtattac aaagaaatga aataaatgaa aaagatacat gggatctatc aacgatctac   60
ccaactgacc aggcttggga agaagcctta aaagatttaa cagaacaatt ggagacagta   120
gcccagtatg aaggccatct cttggatagt gcggataacc tactagaaat cactgaattt   180
tctcttgaaa tggaacgcca gatagagaag ctttacgctt atgctcatat gaagaatgac   240
caggatacac gtgaagctaa gtatcaagag tactatgcca aggccatgac actctacagc   300
cagttagacc aagccttttc attctatgag cctgaattta tggagattag cgaaaagcag   360
tatgctgact ttttagaagc tcaaccaaag ctgcaggttt atcaacacta ttttgacaag   420
cttttgcaag gcaaggatca cgttctttca caacgtgaag aagaattatt ggctggagct   480
ggagaaatct ttggttcagc aagtgaaacc ttcgctatct tggacaatgc ggatattgtg   540
ttcccttatg tcctagacga tgatggtaaa gaagttcagc tatctcatgg gacttacaca   600
cgtttgatgg agtctaaaaa acgtgaggtt cgccgtggtg cctatcaagc tctttatgcg   660
acttacgaac aattccaaca cacctatgcc aaaaccttgc aaaccaatgt taaggtgcaa   720
aattaccgtg ctaaagttcg taactacaag agtgctcgtc atgcagccct cgcagcgaat   780
tttgttccag aaagtgttta tgacaatttg gtagcagcag ttcgcaagca tttgccactc   840
ttacatcgct atcttgagct tcgttcaaaa atcttgggga tttcagatct caagatgtac   900
gatgtctaca caccgctttc atctgttgaa tacagtttta cctaccaaga agccttgaaa   960
aaagcagaag atgctttggc agtcttgggt gaggattact tgagccgtgt taaacgtgcc   1020
ttcagcgagc gttggattga tgtttacgaa aatcaaggca agcgttcagg tgcctactct   1080
ggtggttctt atgataccaa tgcctttatg cttctcaact ggcaagacaa tctggacaat   1140
ctctttactc ttgttcatga aacaggtcac agtatgcatt caagctatac tcgtgaaact   1200
cagccttatg tttacgggga ttactctatc tttttggctg agattgcctc aactaccaat   1260
gaaaatatct tgacggagaa attattggaa gaagtggaag acgacgcaac acgctttgct   1320
attctcaata acttcctaga tggtttccgt ggaacagttt tccgccaaac tcaatttgct   1380
gagtttgaac acgccattca ccaagcagat caaaatgggg aggtcttgac aagcgatttc   1440
ctaaataaac tctacgcaga cttgaaccaa gagtattatg gtttgagtaa ggaagacaat   1500
cctgaaatcc aatacgagtg ggctcgcatt ccacacttct actataacta ctatgtatat   1560
caatattcaa ctggctttgc ggccgcctca gccttggctg aaaaaattgt ccatggtagt   1620
caagaagacc gtgaccgcta tatcgactac ctcaaggcag gtaagtcgga ctatccactt   1680
aatgtcatga gaaaagctgg tgttgatatg gagaaggaag actacctcaa cgatgccttt   1740
gcagtctttg aacgccgttt aaatgagttt gaagcccttg ttgaaaaatt aggattggca   1800

<210>   1930
<211>   600
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligoendopeptidase F (pepF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902926 (0.E+01)

<400>   1930
Met Val Leu Gln Arg Asn Glu Ile Asn Glu Lys Asp Thr Trp Asp Leu 
1               5                   10                  15      

Ser Thr Ile Tyr Pro Thr Asp Gln Ala Trp Glu Glu Ala Leu Lys Asp 
            20                  25                  30          

Leu Thr Glu Gln Leu Glu Thr Val Ala Gln Tyr Glu Gly His Leu Leu 
        35                  40                  45              

Asp Ser Ala Asp Asn Leu Leu Glu Ile Thr Glu Phe Ser Leu Glu Met 
    50                  55                  60                  

Glu Arg Gln Ile Glu Lys Leu Tyr Ala Tyr Ala His Met Lys Asn Asp 
65                  70                  75                  80  

Gln Asp Thr Arg Glu Ala Lys Tyr Gln Glu Tyr Tyr Ala Lys Ala Met 
                85                  90                  95      

Thr Leu Tyr Ser Gln Leu Asp Gln Ala Phe Ser Phe Tyr Glu Pro Glu 
            100                 105                 110         

Phe Met Glu Ile Ser Glu Lys Gln Tyr Ala Asp Phe Leu Glu Ala Gln 
        115                 120                 125             

Pro Lys Leu Gln Val Tyr Gln His Tyr Phe Asp Lys Leu Leu Gln Gly 
    130                 135                 140                 

Lys Asp His Val Leu Ser Gln Arg Glu Glu Glu Leu Leu Ala Gly Ala 
145                 150                 155                 160 

Gly Glu Ile Phe Gly Ser Ala Ser Glu Thr Phe Ala Ile Leu Asp Asn 
                165                 170                 175     

Ala Asp Ile Val Phe Pro Tyr Val Leu Asp Asp Asp Gly Lys Glu Val 
            180                 185                 190         

Gln Leu Ser His Gly Thr Tyr Thr Arg Leu Met Glu Ser Lys Lys Arg 
        195                 200                 205             

Glu Val Arg Arg Gly Ala Tyr Gln Ala Leu Tyr Ala Thr Tyr Glu Gln 
    210                 215                 220                 

Phe Gln His Thr Tyr Ala Lys Thr Leu Gln Thr Asn Val Lys Val Gln 
225                 230                 235                 240 

Asn Tyr Arg Ala Lys Val Arg Asn Tyr Lys Ser Ala Arg His Ala Ala 
                245                 250                 255     

Leu Ala Ala Asn Phe Val Pro Glu Ser Val Tyr Asp Asn Leu Val Ala 
            260                 265                 270         

Ala Val Arg Lys His Leu Pro Leu Leu His Arg Tyr Leu Glu Leu Arg 
        275                 280                 285             

Ser Lys Ile Leu Gly Ile Ser Asp Leu Lys Met Tyr Asp Val Tyr Thr 
    290                 295                 300                 

Pro Leu Ser Ser Val Glu Tyr Ser Phe Thr Tyr Gln Glu Ala Leu Lys 
305                 310                 315                 320 

Lys Ala Glu Asp Ala Leu Ala Val Leu Gly Glu Asp Tyr Leu Ser Arg 
                325                 330                 335     

Val Lys Arg Ala Phe Ser Glu Arg Trp Ile Asp Val Tyr Glu Asn Gln 
            340                 345                 350         

Gly Lys Arg Ser Gly Ala Tyr Ser Gly Gly Ser Tyr Asp Thr Asn Ala 

        355                 360                 365             

Phe Met Leu Leu Asn Trp Gln Asp Asn Leu Asp Asn Leu Phe Thr Leu 
    370                 375                 380                 

Val His Glu Thr Gly His Ser Met His Ser Ser Tyr Thr Arg Glu Thr 
385                 390                 395                 400 

Gln Pro Tyr Val Tyr Gly Asp Tyr Ser Ile Phe Leu Ala Glu Ile Ala 
                405                 410                 415     

Ser Thr Thr Asn Glu Asn Ile Leu Thr Glu Lys Leu Leu Glu Glu Val 
            420                 425                 430         

Glu Asp Asp Ala Thr Arg Phe Ala Ile Leu Asn Asn Phe Leu Asp Gly 
        435                 440                 445             

Phe Arg Gly Thr Val Phe Arg Gln Thr Gln Phe Ala Glu Phe Glu His 
    450                 455                 460                 

Ala Ile His Gln Ala Asp Gln Asn Gly Glu Val Leu Thr Ser Asp Phe 
465                 470                 475                 480 

Leu Asn Lys Leu Tyr Ala Asp Leu Asn Gln Glu Tyr Tyr Gly Leu Ser 
                485                 490                 495     

Lys Glu Asp Asn Pro Glu Ile Gln Tyr Glu Trp Ala Arg Ile Pro His 
            500                 505                 510         

Phe Tyr Tyr Asn Tyr Tyr Val Tyr Gln Tyr Ser Thr Gly Phe Ala Ala 
        515                 520                 525             

Ala Ser Ala Leu Ala Glu Lys Ile Val His Gly Ser Gln Glu Asp Arg 
    530                 535                 540                 

Asp Arg Tyr Ile Asp Tyr Leu Lys Ala Gly Lys Ser Asp Tyr Pro Leu 
545                 550                 555                 560 

Asn Val Met Arg Lys Ala Gly Val Asp Met Glu Lys Glu Asp Tyr Leu 
                565                 570                 575     

Asn Asp Ala Phe Ala Val Phe Glu Arg Arg Leu Asn Glu Phe Glu Ala 
            580                 585                 590         

Leu Val Glu Lys Leu Gly Leu Ala 
        595                 600 

<210>   1931
<211>   711
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1931
atggttgaat cgtatagtaa gaatgctaac cataacatgc gtcgtcctgt cgtcaaagaa   60
gaaattgtag acttgatgcg tcagcgtcaa aagcaggtca caggtttctt gaaagaattg   120
gaagactttg cccgcaagga aaatattcct attattcccc atgaaacggt tgcttatttc   180
cgttttctta tggaaaccat gcagcctaaa aatattctgg aaattgggac ggctatcggt   240
ttttcagctc tcttgatggc tgaacatgcg ccaaatgcta agattacaac tattgatcgt   300
aatccagaaa tgattggttt tgccaaggaa aattttgccc agtttgacag tcgcaagcaa   360
atcactctcc tagagggaga tgcggtggat gtcttatcta cactgacaga gtcttatgat   420
ttcgtcttta tggattctgc caagtctaaa tacatcgtct ttctgccaga aatcctcaaa   480
catttggaag ttggtggtgt ggttgtcttg gatgatattt ttcaaggtgg tgatgttgcc   540
aaggatatta tggaagtccg tcgtggtcag cgaaccattt atcgaggcct tcaaaaatta   600
tttgatgcaa ccttagacaa tccagaactc accgcaacat tagtgccttt aggagatggt   660
attctcatgc ttcgtaaaaa tgtagcagat gttcaactgt ctgaaagcga a            711

<210>   1932
<211>   237
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   O-methyltransferase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902927 (e-132)

<400>   1932
Met Val Glu Ser Tyr Ser Lys Asn Ala Asn His Asn Met Arg Arg Pro 
1               5                   10                  15      

Val Val Lys Glu Glu Ile Val Asp Leu Met Arg Gln Arg Gln Lys Gln 
            20                  25                  30          

Val Thr Gly Phe Leu Lys Glu Leu Glu Asp Phe Ala Arg Lys Glu Asn 
        35                  40                  45              

Ile Pro Ile Ile Pro His Glu Thr Val Ala Tyr Phe Arg Phe Leu Met 
    50                  55                  60                  

Glu Thr Met Gln Pro Lys Asn Ile Leu Glu Ile Gly Thr Ala Ile Gly 
65                  70                  75                  80  

Phe Ser Ala Leu Leu Met Ala Glu His Ala Pro Asn Ala Lys Ile Thr 
                85                  90                  95      

Thr Ile Asp Arg Asn Pro Glu Met Ile Gly Phe Ala Lys Glu Asn Phe 
            100                 105                 110         

Ala Gln Phe Asp Ser Arg Lys Gln Ile Thr Leu Leu Glu Gly Asp Ala 
        115                 120                 125             

Val Asp Val Leu Ser Thr Leu Thr Glu Ser Tyr Asp Phe Val Phe Met 
    130                 135                 140                 

Asp Ser Ala Lys Ser Lys Tyr Ile Val Phe Leu Pro Glu Ile Leu Lys 
145                 150                 155                 160 

His Leu Glu Val Gly Gly Val Val Val Leu Asp Asp Ile Phe Gln Gly 
                165                 170                 175     

Gly Asp Val Ala Lys Asp Ile Met Glu Val Arg Arg Gly Gln Arg Thr 
            180                 185                 190         

Ile Tyr Arg Gly Leu Gln Lys Leu Phe Asp Ala Thr Leu Asp Asn Pro 
        195                 200                 205             

Glu Leu Thr Ala Thr Leu Val Pro Leu Gly Asp Gly Ile Leu Met Leu 
    210                 215                 220                 

Arg Lys Asn Val Ala Asp Val Gln Leu Ser Glu Ser Glu 
225                 230                 235         

<210>   1933
<211>   939
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1933
atgaagaaaa aattattggc aggtgccatc acactattat cagtagcaac tttagcagct   60
tgttcgaaag ggtcagaagg tgcagacctt atcagcatga aaggggatgt cattacagaa   120
catcaatttt atgagcaagt gaaaagcaac ccttcagccc aacaagtctt gttaaatatg   180
accatccaaa aagtttttga aaaacaatat ggctcagagc ttgatgataa agaggttgat   240
gatactattg ccgaagaaaa aaaacaatat ggcgaaaact accaacgtgt cttgtcacaa   300
gcaggtatga ctcttgaaac acgtaaagct caaattcgta caagtaaatt agttgagttg   360
gcagttaaga aggtagcaga agctgaattg acagatgaag cctataagaa agcctttgat   420
gagtacactc cagatgtaac ggctcaaatc atccgtctta ataatgaaga taaggccaaa   480
gaagttctcg aaaaagccaa ggcagaaggt gctgattttg ctcaattagc caaagataat   540
tcaactgatg aaaaaacaaa agaaaatggt ggagaaatta cctttgattc tgcttcaaca   600
gaagtacctg agcaagtcaa aaaagccgct ttcgctttag atgtggatgg tgtttctgat   660
gtgattacag caactggcac acaagcctac agtagccaat attacattgt aaaactcact   720
aagaaaacag aaaaatcatc taatattgat gactacaaag aaaaattaaa aactgttatc   780
ttgactcaaa aacaaaatga ttcaacattt gttcaaagca ttatcggaaa agaattgcaa   840
gcagccaata tcaaggttaa ggaccaagcc ttccaaaata tctttaccca atatatcggt   900
ggtggagatt caagctcaag cagtagtaca tcaaacgaa                          939

<210>   1934
<211>   313
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   protease maturation protein, putative
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902928 (e-172)

<400>   1934
Met Lys Lys Lys Leu Leu Ala Gly Ala Ile Thr Leu Leu Ser Val Ala 
1               5                   10                  15      

Thr Leu Ala Ala Cys Ser Lys Gly Ser Glu Gly Ala Asp Leu Ile Ser 
            20                  25                  30          

Met Lys Gly Asp Val Ile Thr Glu His Gln Phe Tyr Glu Gln Val Lys 
        35                  40                  45              

Ser Asn Pro Ser Ala Gln Gln Val Leu Leu Asn Met Thr Ile Gln Lys 
    50                  55                  60                  

Val Phe Glu Lys Gln Tyr Gly Ser Glu Leu Asp Asp Lys Glu Val Asp 
65                  70                  75                  80  


Asp Thr Ile Ala Glu Glu Lys Lys Gln Tyr Gly Glu Asn Tyr Gln Arg 
                85                  90                  95      

Val Leu Ser Gln Ala Gly Met Thr Leu Glu Thr Arg Lys Ala Gln Ile 
            100                 105                 110         

Arg Thr Ser Lys Leu Val Glu Leu Ala Val Lys Lys Val Ala Glu Ala 
        115                 120                 125             

Glu Leu Thr Asp Glu Ala Tyr Lys Lys Ala Phe Asp Glu Tyr Thr Pro 
    130                 135                 140                 

Asp Val Thr Ala Gln Ile Ile Arg Leu Asn Asn Glu Asp Lys Ala Lys 
145                 150                 155                 160 

Glu Val Leu Glu Lys Ala Lys Ala Glu Gly Ala Asp Phe Ala Gln Leu 
                165                 170                 175     

Ala Lys Asp Asn Ser Thr Asp Glu Lys Thr Lys Glu Asn Gly Gly Glu 
            180                 185                 190         

Ile Thr Phe Asp Ser Ala Ser Thr Glu Val Pro Glu Gln Val Lys Lys 
        195                 200                 205             

Ala Ala Phe Ala Leu Asp Val Asp Gly Val Ser Asp Val Ile Thr Ala 
    210                 215                 220                 

Thr Gly Thr Gln Ala Tyr Ser Ser Gln Tyr Tyr Ile Val Lys Leu Thr 
225                 230                 235                 240 

Lys Lys Thr Glu Lys Ser Ser Asn Ile Asp Asp Tyr Lys Glu Lys Leu 
                245                 250                 255     

Lys Thr Val Ile Leu Thr Gln Lys Gln Asn Asp Ser Thr Phe Val Gln 
            260                 265                 270         

Ser Ile Ile Gly Lys Glu Leu Gln Ala Ala Asn Ile Lys Val Lys Asp 
        275                 280                 285             

Gln Ala Phe Gln Asn Ile Phe Thr Gln Tyr Ile Gly Gly Gly Asp Ser 
    290                 295                 300                 

Ser Ser Ser Ser Ser Thr Ser Asn Glu 
305                 310             

<210>   1935
<211>   339
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1935
atgttggaac aggcattcaa agagaagcac tacgagaata cgattctcca tagtgaccaa   60
ggctggcaat atcaacacga ttcttatcat cgcttcctag agagtaaggg aattcaagca   120
tccatgtcac gtaagggcaa cagccaagac aacggtagga tggaatcttt ctttggcatt   180
ttaaaatccg aaatgtttta tggctatgag aaaacattta aatcacttaa tcaattggaa   240
cgagccatta tagactatat tgattattac aacaataaga gaattaagat aaaactaaaa   300
ggacttagct ctgtgcaata cagaactaaa tccttcgga                          339

<210>   1936
<211>   113
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   1936
Met Leu Glu Gln Ala Phe Lys Glu Lys His Tyr Glu Asn Thr Ile Leu 
1               5                   10                  15      

His Ser Asp Gln Gly Trp Gln Tyr Gln His Asp Ser Tyr His Arg Phe 
            20                  25                  30          

Leu Glu Ser Lys Gly Ile Gln Ala Ser Met Ser Arg Lys Gly Asn Ser 
        35                  40                  45              

Gln Asp Asn Gly Arg Met Glu Ser Phe Phe Gly Ile Leu Lys Ser Glu 
    50                  55                  60                  

Met Phe Tyr Gly Tyr Glu Lys Thr Phe Lys Ser Leu Asn Gln Leu Glu 
65                  70                  75                  80  

Arg Ala Ile Ile Asp Tyr Ile Asp Tyr Tyr Asn Asn Lys Arg Ile Lys 
                85                  90                  95      

Ile Lys Leu Lys Gly Leu Ser Ser Val Gln Tyr Arg Thr Lys Ser Phe 
            100                 105                 110         

Gly 
    

<210>   1937
<211>   473

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1937
atgaaattaa cttatgatga taaagttcag atctatgaac ttagaaaaca aggatatagc   60
ttagagaagc tttcaaataa atttgggata aacaattcta atcttaggta catgattaaa   120
ttgattgatc gttaatgttg gaacaggcat tcaaagagaa gcactacgag aatacgattc   180
tccatagtga ccaaggctgg caatatcaac acgattctta tcatcgcttc ctagagagta   240
agggaattca agcatccatg tcacgtaagg gcaacagcca agacaacggt aggatggaat   300
ctttctttgg cattttaaaa tccgaaatgt tttatggcta tgagaaaaca tttaaatcac   360
ttaatcaatt ggaacgagcc attatagact atattgatta ttacaacaat aagagaatta   420
agataaaact aaaaggactt agctctgtgc aatacagaac taaatccttc gga          473

<210>   1938
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, hypothetical protein/transposase, internal deletion

<400>   1938
Met Tyr Met Asn Tyr Thr Pro Lys Val Arg Gln Lys Lys Ser Asn Phe 
1               5                   10                  15      

Trp Gly Val Phe Ile Met Lys Leu Thr Tyr Asp Asp Lys Val Gln Ile 
            20                  25                  30          

Tyr Glu Leu Arg Lys Gln Gly Tyr Ser Leu Glu Lys Leu Ser Asn Lys 
        35                  40                  45              

Phe Gly Ile Asn Asn Ser Asn Leu Arg Tyr Met Ile Lys Leu Ile Asp 
    50                  55                  60                  

Arg 
65  

<210>   1939
<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1939
atgagtaggg aggaaaaggt aaaagtttat gcccaaactc ttcacataag aactctagct   60
tacccattct atggaatctt gcattatcca ttaaaacttc cagactcata ctcttctaaa   120
atctattcaa accacgtcag cttcacatta tatatgttgg tgacctcaca agttttatct   180
acaacctcaa agctgttctt tgagcagcct acagctagct tcctagtt                228

<210>   1940
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1940
Met Ser Arg Glu Glu Lys Val Lys Val Tyr Ala Gln Thr Leu His Ile 
1               5                   10                  15      

Arg Thr Leu Ala Tyr Pro Phe Tyr Gly Ile Leu His Tyr Pro Leu Lys 
            20                  25                  30          

Leu Pro Asp Ser Tyr Ser Ser Lys Ile Tyr Ser Asn His Val Ser Phe 
        35                  40                  45              

Thr Leu Tyr Met Leu Val Thr Ser Gln Val Leu Ser Thr Thr Ser Lys 
    50                  55                  60                  

Leu Phe Phe Glu Gln Pro Thr Ala Ser Phe Leu Val 
65                  70                  75      

<210>   1941
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1941
ttgttctaca atcctgttga gaagacacgt gttcatatca aaaaggtatt ggcaagttgc   60
aatacctttt tacgaggctc tgttgtctta tttttgtttc aactgactat atctcctatg   120
gttctagttc agaaggctag gcta                                          144

<210>   1942
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf2, degenerate

<400>   1942
Met Phe Tyr Asn Pro Val Glu Lys Thr Arg Val His Ile Lys Lys Val 
1               5                   10                  15      

Leu Ala Ser Cys Asn Thr Phe Leu Arg Gly Ser Val Val Leu Phe Leu 
            20                  25                  30          

Phe Gln Leu Thr Ile Ser Pro Met Val Leu Val Gln Lys Ala Arg Leu 
        35                  40                  45              


<210>   1943
<211>   618
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1943
atgaaactct actttgtccg ccacggtcgt accctctgga accaagaagg tcgttttcaa   60
ggtgctagtg gtgattctcc tcttcttcct gaatccattg aaaccctaaa acgacttggt   120
cagtatctca aggaaattcc ttttgatcag atttattcaa gtgatttacc tcgagcggtc   180
aaatctgctg agattatcca aagtcaactc tataccccct gttctttaga aatcgttcct   240
aatctccgtg aatggcaact tgggaagtta gaaggtttga aaattgcaac cttggaagct   300
atttacccgc aacaaatcca ggcttttcgt tcaaatcttg ctcaatttga cactcgaatg   360
ttcggagccg aatccctcta tagtacaact caacggacca tccaatttat caaatcatta   420
aaagatagtc cagctgaacg tattctaatt gtcggacacg gcgccaatct tactgccagt   480
cttcgtactc tcctaggcta taaagaacca cttcttcgta aagatggcgg tctagcaaat   540
gccagcctga ccattataga aacccatgat tttgaaacat tcactcccaa tacttggaat   600
gatacttctt atcaatca                                                 618

<210>   1944
<211>   206
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoglycerate mutase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902931 (e-115)

<400>   1944
Met Lys Leu Tyr Phe Val Arg His Gly Arg Thr Leu Trp Asn Gln Glu 
1               5                   10                  15      

Gly Arg Phe Gln Gly Ala Ser Gly Asp Ser Pro Leu Leu Pro Glu Ser 
            20                  25                  30          

Ile Glu Thr Leu Lys Arg Leu Gly Gln Tyr Leu Lys Glu Ile Pro Phe 
        35                  40                  45              

Asp Gln Ile Tyr Ser Ser Asp Leu Pro Arg Ala Val Lys Ser Ala Glu 
    50                  55                  60                  

Ile Ile Gln Ser Gln Leu Tyr Thr Pro Cys Ser Leu Glu Ile Val Pro 
65                  70                  75                  80  

Asn Leu Arg Glu Trp Gln Leu Gly Lys Leu Glu Gly Leu Lys Ile Ala 
                85                  90                  95      

Thr Leu Glu Ala Ile Tyr Pro Gln Gln Ile Gln Ala Phe Arg Ser Asn 
            100                 105                 110         

Leu Ala Gln Phe Asp Thr Arg Met Phe Gly Ala Glu Ser Leu Tyr Ser 
        115                 120                 125             

Thr Thr Gln Arg Thr Ile Gln Phe Ile Lys Ser Leu Lys Asp Ser Pro 
    130                 135                 140                 

Ala Glu Arg Ile Leu Ile Val Gly His Gly Ala Asn Leu Thr Ala Ser 
145                 150                 155                 160 

Leu Arg Thr Leu Leu Gly Tyr Lys Glu Pro Leu Leu Arg Lys Asp Gly 
                165                 170                 175     

Gly Leu Ala Asn Ala Ser Leu Thr Ile Ile Glu Thr His Asp Phe Glu 
            180                 185                 190         

Thr Phe Thr Pro Asn Thr Trp Asn Asp Thr Ser Tyr Gln Ser 
        195                 200                 205     

<210>   1945
<211>   480
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1945
atggcaaaaa aagttaaaat caaaaaaaca ttggtggaac aaatcctatc taaagcagct   60
atccctcatc aggggattca aatcaatgcc ctagaaggag agcttcctca aggttatgaa   120
cgagatcaga ttttcaaaac cttggcgctt ttgggagaca agaccggacc gattatcgga   180
attgtcccta tcactcagca cttgtctgaa aagaaactag ctaaaatttc tggcaataaa   240
aaagtgagca tgattccaca aaaggactta gaaaaaacaa ctggttacat tcatggagcc   300
aataatcctg tcggaattcg tcagaaacac aattatccca tttttatcga taaaattgct   360
ctagatttgg atcaaatgat tgtctctgca ggcgaagtcg gacacagcat tatcgtcgcg   420
ccacaagact tggctagctt tgtaaaggca gactttgtag atattttgga ggacatcaag   480

<210>   1946
<211>   160
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   regulatory protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902932 (6.E-87)

<400>   1946
Met Ala Lys Lys Val Lys Ile Lys Lys Thr Leu Val Glu Gln Ile Leu 
1               5                   10                  15      

Ser Lys Ala Ala Ile Pro His Gln Gly Ile Gln Ile Asn Ala Leu Glu 
            20                  25                  30          

Gly Glu Leu Pro Gln Gly Tyr Glu Arg Asp Gln Ile Phe Lys Thr Leu 
        35                  40                  45              

Ala Leu Leu Gly Asp Lys Thr Gly Pro Ile Ile Gly Ile Val Pro Ile 
    50                  55                  60                  

Thr Gln His Leu Ser Glu Lys Lys Leu Ala Lys Ile Ser Gly Asn Lys 
65                  70                  75                  80  

Lys Val Ser Met Ile Pro Gln Lys Asp Leu Glu Lys Thr Thr Gly Tyr 
                85                  90                  95      

Ile His Gly Ala Asn Asn Pro Val Gly Ile Arg Gln Lys His Asn Tyr 
            100                 105                 110         

Pro Ile Phe Ile Asp Lys Ile Ala Leu Asp Leu Asp Gln Met Ile Val 
        115                 120                 125             

Ser Ala Gly Glu Val Gly His Ser Ile Ile Val Ala Pro Gln Asp Leu 
    130                 135                 140                 

Ala Ser Phe Val Lys Ala Asp Phe Val Asp Ile Leu Glu Asp Ile Lys 
145                 150                 155                 160 


<210>   1947
<211>   840
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1947
atgctctcat ggttagcacg cgttattaaa gggattgtaa ttgctcttgg atttatccta   60
ccgggaattt ccggaggggt tctagcagca atcttaggaa tctatgaacg aatgattggc   120
tttctggccc atccctttaa agactttaaa gaaaatgttt tgtactttat tccagttgcc   180
atcggtatgc ttctgggaat cggcttattt tcctacccga ttgaatacct gcttgaaaat   240
tatcaggttt ttgtattatg gagctttgcg ggagctatta tcggtacagt tcctagcctc   300
ctcaaagaat caactcgaga atctgaccga gacaagattg atttagcttg gttatggaca   360
acctttatca tttctggatt aggactctat gccttaaatt ttgtcgttgg aaccttaagc   420
gccagctttc ttaacttcgt cctagcaggc gcactattgg cccttggcgt cttggttcct   480
ggcctcagcc catcaaattt acttttgatt ttgggactct atgctcctat gttgactggt   540
tttaaaactt ttgatttctt gggaaccttc tttccgattg gaattggtgc aggtgcaact   600
ctcatcgttt tttcaaaatt gatagattat gccttaaaca actaccactc acgcgtctat   660
catttcatca tcggtatcgt cctatcaagt acccttttga tcttaattcc aaatgcagga   720
aacgctgaaa gtatccaata cacaggactt tcacttgtcg gttatgtcat catcgccttc   780
ttctttgcgc tgggaatctg gcttggtatt tggatgagtc aattggagga taaatataaa   840

<210>   1948
<211>   280
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902933 (e-157)

<400>   1948
Met Leu Ser Trp Leu Ala Arg Val Ile Lys Gly Ile Val Ile Ala Leu 
1               5                   10                  15      

Gly Phe Ile Leu Pro Gly Ile Ser Gly Gly Val Leu Ala Ala Ile Leu 
            20                  25                  30          

Gly Ile Tyr Glu Arg Met Ile Gly Phe Leu Ala His Pro Phe Lys Asp 
        35                  40                  45              

Phe Lys Glu Asn Val Leu Tyr Phe Ile Pro Val Ala Ile Gly Met Leu 
    50                  55                  60                  

Leu Gly Ile Gly Leu Phe Ser Tyr Pro Ile Glu Tyr Leu Leu Glu Asn 
65                  70                  75                  80  

Tyr Gln Val Phe Val Leu Trp Ser Phe Ala Gly Ala Ile Ile Gly Thr 
                85                  90                  95      

Val Pro Ser Leu Leu Lys Glu Ser Thr Arg Glu Ser Asp Arg Asp Lys 
            100                 105                 110         

Ile Asp Leu Ala Trp Leu Trp Thr Thr Phe Ile Ile Ser Gly Leu Gly 
        115                 120                 125             

Leu Tyr Ala Leu Asn Phe Val Val Gly Thr Leu Ser Ala Ser Phe Leu 
    130                 135                 140                 

Asn Phe Val Leu Ala Gly Ala Leu Leu Ala Leu Gly Val Leu Val Pro 
145                 150                 155                 160 

Gly Leu Ser Pro Ser Asn Leu Leu Leu Ile Leu Gly Leu Tyr Ala Pro 
                165                 170                 175     

Met Leu Thr Gly Phe Lys Thr Phe Asp Phe Leu Gly Thr Phe Phe Pro 
            180                 185                 190         

Ile Gly Ile Gly Ala Gly Ala Thr Leu Ile Val Phe Ser Lys Leu Ile 
        195                 200                 205             

Asp Tyr Ala Leu Asn Asn Tyr His Ser Arg Val Tyr His Phe Ile Ile 
    210                 215                 220                 

Gly Ile Val Leu Ser Ser Thr Leu Leu Ile Leu Ile Pro Asn Ala Gly 
225                 230                 235                 240 

Asn Ala Glu Ser Ile Gln Tyr Thr Gly Leu Ser Leu Val Gly Tyr Val 
                245                 250                 255     

Ile Ile Ala Phe Phe Phe Ala Leu Gly Ile Trp Leu Gly Ile Trp Met 
            260                 265                 270         

Ser Gln Leu Glu Asp Lys Tyr Lys 
        275                 280 

<210>   1949
<211>   798
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1949
atgagaaaac aaattcatcc acttatttta tttagttttt ttgggattat gatgttcatt   60
ttaatcatca atcgcccact taatgacagc caatcgttta aaacaaaatc caatatagca   120
cagattgaag cacaggcttt gaaacactta gacaaaccga ttattgacct ctctggctgg   180
cagcgtcctg aggaaatcaa ctacgatgcc ctctcacaaa atatttcagg tgctattgtt   240
cgtgttcaca gtggtgctca aacgacaaaa gaaaatgatg cttcatttat caatggaata   300
gacaaggcct ataagagtca tatcactgaa cttcaaaagc ggaatgtccc agttgctgtc   360
tacgcttatg tagctggaaa aagtgtccaa gaaatggaaa aggctgccga agttttctac   420
aatgctgcct ctccttacag ccctagttac tattggcttg acgtggaaga caaaaccatg   480
tctaatatga acgaaggtgt cgaaaacttt cgagcaaaac tagcatcact gggtgctaaa   540
aacatcggca tctacgttgg tgtctacttc atggaagaac acagtattga tacaggcaag   600
tttacctctg tttggattcc gtcctacggc tcagactcag gatttttgga gagcagtcct   660
aaaactgatt tagattatga tattcaccaa tacacatcta aaggaaaaat tgccggcttt   720
gaccacgatt tagatatcaa cgttatctct cccttaaaaa ataaagaaga aacctttcga   780
aaactttttt taaaacct                                                 798

<210>   1950
<211>   266
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902934 (e-153)

<400>   1950
Met Arg Lys Gln Ile His Pro Leu Ile Leu Phe Ser Phe Phe Gly Ile 
1               5                   10                  15      

Met Met Phe Ile Leu Ile Ile Asn Arg Pro Leu Asn Asp Ser Gln Ser 
            20                  25                  30          

Phe Lys Thr Lys Ser Asn Ile Ala Gln Ile Glu Ala Gln Ala Leu Lys 
        35                  40                  45              

His Leu Asp Lys Pro Ile Ile Asp Leu Ser Gly Trp Gln Arg Pro Glu 
    50                  55                  60                  

Glu Ile Asn Tyr Asp Ala Leu Ser Gln Asn Ile Ser Gly Ala Ile Val 
65                  70                  75                  80  

Arg Val His Ser Gly Ala Gln Thr Thr Lys Glu Asn Asp Ala Ser Phe 
                85                  90                  95      

Ile Asn Gly Ile Asp Lys Ala Tyr Lys Ser His Ile Thr Glu Leu Gln 
            100                 105                 110         

Lys Arg Asn Val Pro Val Ala Val Tyr Ala Tyr Val Ala Gly Lys Ser 
        115                 120                 125             

Val Gln Glu Met Glu Lys Ala Ala Glu Val Phe Tyr Asn Ala Ala Ser 
    130                 135                 140                 

Pro Tyr Ser Pro Ser Tyr Tyr Trp Leu Asp Val Glu Asp Lys Thr Met 
145                 150                 155                 160 

Ser Asn Met Asn Glu Gly Val Glu Asn Phe Arg Ala Lys Leu Ala Ser 
                165                 170                 175     

Leu Gly Ala Lys Asn Ile Gly Ile Tyr Val Gly Val Tyr Phe Met Glu 
            180                 185                 190         

Glu His Ser Ile Asp Thr Gly Lys Phe Thr Ser Val Trp Ile Pro Ser 
        195                 200                 205             

Tyr Gly Ser Asp Ser Gly Phe Leu Glu Ser Ser Pro Lys Thr Asp Leu 
    210                 215                 220                 

Asp Tyr Asp Ile His Gln Tyr Thr Ser Lys Gly Lys Ile Ala Gly Phe 
225                 230                 235                 240 

Asp His Asp Leu Asp Ile Asn Val Ile Ser Pro Leu Lys Asn Lys Glu 
                245                 250                 255     

Glu Thr Phe Arg Lys Leu Phe Leu Lys Pro 
            260                 265     

<210>   1951
<211>   1437
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1951
gtgcggaatg atttgaaata tggtataata aaagggaatt tctacagaaa agagaagatt   60
atgtcaaatt ttgccattat tttagcagcg ggtaaaggga ctcgcatgaa atctgatttg   120
ccaaaagttt tgcacaaggt tgcgggtatt tctatgttgg aacatgtttt ccgtagtgtg   180
ggagctatcc aacctgaaaa gacagtaaca gttgtaggac acaaggcaga attggttgag   240
gaggtcttgg ctggacagac agaatttgtg actcaatctg aacagttggg aactggtcat   300
gcagttatga tgacagagcc tatcttagaa ggtttgtcag gacacacctt ggtcattgca   360
ggagatactc ctttaatcac tggtgaaagc ttgaaaaact tgattgattt ccatatcaat   420
cataaaaatg tggccactat cttgactgct gaaacggata atccttttgg ttatggacga   480
attgttcgta atgacaatgc tgaggttctt cgtattgttg agcagaagga tgctacagat   540
tttgaaaagc aaatcaagga aatcaacact ggaacatacg tctttgacaa cgagcgtttg   600
tttgaggctt tgaaaaatat caataccaat aacgctcaag gcgaatacta tattacagac   660
gtcattggta ttttccgtga aactggtgaa aaagttggcg cttatacttt gaaagatttt   720
gatgaaagtc ttggggtaaa tgaccgtgtg gcgcttgcga cagctgagtc agttatgcgt   780
cgtcgcatca atcataaaca catggtcaac ggtgttagct ttgtcaatcc agaagcaact   840
tatatcgata ttgatgttga gattgcttcg gaagttcaaa tcgaagccaa tgttaccttg   900
aaagggcaaa cgaaaattgg tgctgagact gttttgacaa acggtactta tgtagtggac   960
agcactatcg gagcaggagc ggtcattacc aattctatga ttgaggaaag tagtgttgca   1020
gacggtgtga tagtcggtcc ttatgctcac attcgtccaa attcaagtct gggtgcccaa   1080
gttcatattg gtaactttgt tgaggtgaaa ggatcttcaa tcggtgagaa taccaaggct   1140
ggtcatttga cttatatcgg aaactgtgaa gtgggaagca acgttaattt cggtgctgga   1200
actattacag tcaactatga cggcaaaaac aaatacaaga cagtcattgg aaacaatgtc   1260
tttgttggtt caaattcaac cattattgca ccagtagaac ttggtgacaa ttccctcgtt   1320
ggtgctggtt caactattac taaagacgtg ccagcagatg ctattgctat tggtcgcggt   1380
cgtcagatca ataaagacga atatgcaaca cgtcttcctc atcatcctaa gaaccag      1437

<210>   1952
<211>   479
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylglucosamine pyrophosphorylase (glmU)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902935 (0.E+01)

<400>   1952
Met Arg Asn Asp Leu Lys Tyr Gly Ile Ile Lys Gly Asn Phe Tyr Arg 
1               5                   10                  15      

Lys Glu Lys Ile Met Ser Asn Phe Ala Ile Ile Leu Ala Ala Gly Lys 
            20                  25                  30          

Gly Thr Arg Met Lys Ser Asp Leu Pro Lys Val Leu His Lys Val Ala 
        35                  40                  45              

Gly Ile Ser Met Leu Glu His Val Phe Arg Ser Val Gly Ala Ile Gln 
    50                  55                  60                  

Pro Glu Lys Thr Val Thr Val Val Gly His Lys Ala Glu Leu Val Glu 
65                  70                  75                  80  

Glu Val Leu Ala Gly Gln Thr Glu Phe Val Thr Gln Ser Glu Gln Leu 
                85                  90                  95      

Gly Thr Gly His Ala Val Met Met Thr Glu Pro Ile Leu Glu Gly Leu 
            100                 105                 110         

Ser Gly His Thr Leu Val Ile Ala Gly Asp Thr Pro Leu Ile Thr Gly 
        115                 120                 125             

Glu Ser Leu Lys Asn Leu Ile Asp Phe His Ile Asn His Lys Asn Val 
    130                 135                 140                 

Ala Thr Ile Leu Thr Ala Glu Thr Asp Asn Pro Phe Gly Tyr Gly Arg 
145                 150                 155                 160 

Ile Val Arg Asn Asp Asn Ala Glu Val Leu Arg Ile Val Glu Gln Lys 
                165                 170                 175     

Asp Ala Thr Asp Phe Glu Lys Gln Ile Lys Glu Ile Asn Thr Gly Thr 
            180                 185                 190         

Tyr Val Phe Asp Asn Glu Arg Leu Phe Glu Ala Leu Lys Asn Ile Asn 
        195                 200                 205             

Thr Asn Asn Ala Gln Gly Glu Tyr Tyr Ile Thr Asp Val Ile Gly Ile 
    210                 215                 220                 

Phe Arg Glu Thr Gly Glu Lys Val Gly Ala Tyr Thr Leu Lys Asp Phe 
225                 230                 235                 240 

Asp Glu Ser Leu Gly Val Asn Asp Arg Val Ala Leu Ala Thr Ala Glu 

                245                 250                 255     

Ser Val Met Arg Arg Arg Ile Asn His Lys His Met Val Asn Gly Val 
            260                 265                 270         

Ser Phe Val Asn Pro Glu Ala Thr Tyr Ile Asp Ile Asp Val Glu Ile 
        275                 280                 285             

Ala Ser Glu Val Gln Ile Glu Ala Asn Val Thr Leu Lys Gly Gln Thr 
    290                 295                 300                 

Lys Ile Gly Ala Glu Thr Val Leu Thr Asn Gly Thr Tyr Val Val Asp 
305                 310                 315                 320 

Ser Thr Ile Gly Ala Gly Ala Val Ile Thr Asn Ser Met Ile Glu Glu 
                325                 330                 335     

Ser Ser Val Ala Asp Gly Val Ile Val Gly Pro Tyr Ala His Ile Arg 
            340                 345                 350         

Pro Asn Ser Ser Leu Gly Ala Gln Val His Ile Gly Asn Phe Val Glu 
        355                 360                 365             

Val Lys Gly Ser Ser Ile Gly Glu Asn Thr Lys Ala Gly His Leu Thr 
    370                 375                 380                 

Tyr Ile Gly Asn Cys Glu Val Gly Ser Asn Val Asn Phe Gly Ala Gly 
385                 390                 395                 400 

Thr Ile Thr Val Asn Tyr Asp Gly Lys Asn Lys Tyr Lys Thr Val Ile 
                405                 410                 415     

Gly Asn Asn Val Phe Val Gly Ser Asn Ser Thr Ile Ile Ala Pro Val 
            420                 425                 430         

Glu Leu Gly Asp Asn Ser Leu Val Gly Ala Gly Ser Thr Ile Thr Lys 
        435                 440                 445             

Asp Val Pro Ala Asp Ala Ile Ala Ile Gly Arg Gly Arg Gln Ile Asn 
    450                 455                 460                 

Lys Asp Glu Tyr Ala Thr Arg Leu Pro His His Pro Lys Asn Gln 
465                 470                 475                 

<210>   1953
<211>   543
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1953
atggagtttg aagaaaaaac gcttagccga aaagaaatct atcaaggacc aatatttaaa   60
ctggtccaag atcaggttga attaccagaa ggcaagggaa ctgcccaacg ggatttgatt   120
ttccacaatg gggctgtctg tgttttagca gtaacggatg aacaaaaact tatcttggtc   180
aagcagtacc gcaaagctat cgaggctgtc tcttacgaaa ttccagccgg aaaattggaa   240
gtaggagaaa acacagcccc tgtggcagct gcccttcgtg aattagagga agaaacagcc   300
tatacaggga aattagaact cttgtacgat ttttattcag ctattggctt ttgtaatgag   360
aagttaaaac tatatttagc aagcgatttg acaaaagtgg aaaatccgcg tccgcaggat   420
gaggatgaaa ccttggaagt ccttgaagtg agcttagaag aagcgaaaga attaatccaa   480
tcaggtcata tctgtgatgc caagacaatt atggctgttc agtattggga gttgcagaaa   540
aaa                                                                 543

<210>   1954
<211>   181
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MutT/nudix family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902936 (e-100)

<400>   1954
Met Glu Phe Glu Glu Lys Thr Leu Ser Arg Lys Glu Ile Tyr Gln Gly 
1               5                   10                  15      

Pro Ile Phe Lys Leu Val Gln Asp Gln Val Glu Leu Pro Glu Gly Lys 
            20                  25                  30          

Gly Thr Ala Gln Arg Asp Leu Ile Phe His Asn Gly Ala Val Cys Val 
        35                  40                  45              

Leu Ala Val Thr Asp Glu Gln Lys Leu Ile Leu Val Lys Gln Tyr Arg 
    50                  55                  60                  

Lys Ala Ile Glu Ala Val Ser Tyr Glu Ile Pro Ala Gly Lys Leu Glu 
65                  70                  75                  80  

Val Gly Glu Asn Thr Ala Pro Val Ala Ala Ala Leu Arg Glu Leu Glu 
                85                  90                  95      

Glu Glu Thr Ala Tyr Thr Gly Lys Leu Glu Leu Leu Tyr Asp Phe Tyr 
            100                 105                 110         

Ser Ala Ile Gly Phe Cys Asn Glu Lys Leu Lys Leu Tyr Leu Ala Ser 
        115                 120                 125             

Asp Leu Thr Lys Val Glu Asn Pro Arg Pro Gln Asp Glu Asp Glu Thr 
    130                 135                 140                 

Leu Glu Val Leu Glu Val Ser Leu Glu Glu Ala Lys Glu Leu Ile Gln 
145                 150                 155                 160 

Ser Gly His Ile Cys Asp Ala Lys Thr Ile Met Ala Val Gln Tyr Trp 
                165                 170                 175     

Glu Leu Gln Lys Lys 
            180     

<210>   1955
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1955
ttgggagttg cagaaaaaat agaggaggtc agtatgggta aatctttatt aacggatgaa   60
atgattgaaa gagctaatag aggcgaaaaa atttcaggtc ctcctttgct agatgataat   120
gaggaaacta agattttacc aacctcttct tcccgttttg gttatgccaa tcctaaggat   180
catggtttta gccaggaaac cttgaagatt caggtcgaac catctattca taaaagccgt   240
cgtattgaaa ataccaagag aaatgtcttc aattctaagt tgaataaaat cttatttgcg   300
gtcatctttc tcttgatttt gcttgtttta gcaatgaaac ttttg                   345

<210>   1956
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902937 (2.E-60)

<400>   1956
Met Gly Val Ala Glu Lys Ile Glu Glu Val Ser Met Gly Lys Ser Leu 
1               5                   10                  15      

Leu Thr Asp Glu Met Ile Glu Arg Ala Asn Arg Gly Glu Lys Ile Ser 
            20                  25                  30          

Gly Pro Pro Leu Leu Asp Asp Asn Glu Glu Thr Lys Ile Leu Pro Thr 
        35                  40                  45              

Ser Ser Ser Arg Phe Gly Tyr Ala Asn Pro Lys Asp His Gly Phe Ser 
    50                  55                  60                  

Gln Glu Thr Leu Lys Ile Gln Val Glu Pro Ser Ile His Lys Ser Arg 
65                  70                  75                  80  

Arg Ile Glu Asn Thr Lys Arg Asn Val Phe Asn Ser Lys Leu Asn Lys 
                85                  90                  95      

Ile Leu Phe Ala Val Ile Phe Leu Leu Ile Leu Leu Val Leu Ala Met 
            100                 105                 110         

Lys Leu Leu 
        115 

<210>   1957
<211>   690
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1957
atgaaaatag gaattattgc tgctatgcca gaagaactgg cttatctggt ccagcattta   60
gataatgccc aggagcaagt tgtttttggg aatacctatc atacaggaac cattgcttct   120
catgaagtcg ttcttgtaga aagtggaatt ggtaaggtca tgtctgctat gagtgtggcg   180
attttggctg atcatttcca ggtggatgcc cttattaata cgggttcagc tggggcagta   240
gcagaaggta tcgctgttgg ggatgtcgtg attgctgaca aattagccta tcatgacgtg   300
gatgtcacag cttttggcta tgcttatgga caaatggcgc aacaaccgct ttatttcgaa   360
tcagacaaaa cctttgttgc tcaaatccaa aagagtttat ctcaattgga ccaaaactgg   420
catcttggtt tgattgctac aggagatagt tttgttgcag gaaatgacaa gatagaagcg   480
attaagtccc atttcccaga agttttagcc gtggagatgg agggggcagc tattgctcaa   540
gcagcgcatg ccctcaatct cccagtctta gtcatccgag ctatgagtga caatgccaac   600
catgaagcaa acatcttttt tgatgagttt attatcgaag ctggacgtcg ctctgcccaa   660
gtcttgttga cctttttgaa ggctttagat                                    690

<210>   1958
<211>   230
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtf)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902938 (e-124)

<400>   1958
Met Lys Ile Gly Ile Ile Ala Ala Met Pro Glu Glu Leu Ala Tyr Leu 
1               5                   10                  15      

Val Gln His Leu Asp Asn Ala Gln Glu Gln Val Val Phe Gly Asn Thr 
            20                  25                  30          

Tyr His Thr Gly Thr Ile Ala Ser His Glu Val Val Leu Val Glu Ser 
        35                  40                  45              

Gly Ile Gly Lys Val Met Ser Ala Met Ser Val Ala Ile Leu Ala Asp 
    50                  55                  60                  

His Phe Gln Val Asp Ala Leu Ile Asn Thr Gly Ser Ala Gly Ala Val 
65                  70                  75                  80  

Ala Glu Gly Ile Ala Val Gly Asp Val Val Ile Ala Asp Lys Leu Ala 
                85                  90                  95      

Tyr His Asp Val Asp Val Thr Ala Phe Gly Tyr Ala Tyr Gly Gln Met 
            100                 105                 110         

Ala Gln Gln Pro Leu Tyr Phe Glu Ser Asp Lys Thr Phe Val Ala Gln 
        115                 120                 125             

Ile Gln Lys Ser Leu Ser Gln Leu Asp Gln Asn Trp His Leu Gly Leu 
    130                 135                 140                 

Ile Ala Thr Gly Asp Ser Phe Val Ala Gly Asn Asp Lys Ile Glu Ala 
145                 150                 155                 160 

Ile Lys Ser His Phe Pro Glu Val Leu Ala Val Glu Met Glu Gly Ala 
                165                 170                 175     

Ala Ile Ala Gln Ala Ala His Ala Leu Asn Leu Pro Val Leu Val Ile 
            180                 185                 190         

Arg Ala Met Ser Asp Asn Ala Asn His Glu Ala Asn Ile Phe Phe Asp 
        195                 200                 205             

Glu Phe Ile Ile Glu Ala Gly Arg Arg Ser Ala Gln Val Leu Leu Thr 
    210                 215                 220                 

Phe Leu Lys Ala Leu Asp 
225                 230 

<210>   1959
<211>   489
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1959
atgagtattg aaatgaccgt cagtgagatt gcagaggtct taggattatc tcgccaagca   60
atcaataacc gtgtcaaaga attaccagaa gaagacacag ataaaaatga caaaggggta   120
acagttgtta ccagaagtgg cttgattaag ctagaagaaa tctataaaaa aacgattttt   180
gaagatgagc ctgtcagtga agatgtcaaa caacgtgaac tgatggagat tctagtggat   240
gagaagaatg cagaaattct tcgtctttat gaacaattaa aagccaagga tcgtcagtta   300
tcagaaaaag acgagcagat gcgtatcaaa gaccgtcaga ttgctgagaa agacaaacaa   360
ttagatcagc aacaacaatt gacccttcaa gccatgaagg atcaagaaaa tcttaagcta   420
gagctggacc aagcaaaaga agaagtccaa tccactaaaa aaggcttttt tgctcgttta   480
tttggagga                                                           489

<210>   1960
<211>   163
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902939 (7.E-87)

<400>   1960
Met Ser Ile Glu Met Thr Val Ser Glu Ile Ala Glu Val Leu Gly Leu 
1               5                   10                  15      

Ser Arg Gln Ala Ile Asn Asn Arg Val Lys Glu Leu Pro Glu Glu Asp 
            20                  25                  30          

Thr Asp Lys Asn Asp Lys Gly Val Thr Val Val Thr Arg Ser Gly Leu 
        35                  40                  45              

Ile Lys Leu Glu Glu Ile Tyr Lys Lys Thr Ile Phe Glu Asp Glu Pro 
    50                  55                  60                  

Val Ser Glu Asp Val Lys Gln Arg Glu Leu Met Glu Ile Leu Val Asp 
65                  70                  75                  80  

Glu Lys Asn Ala Glu Ile Leu Arg Leu Tyr Glu Gln Leu Lys Ala Lys 
                85                  90                  95      

Asp Arg Gln Leu Ser Glu Lys Asp Glu Gln Met Arg Ile Lys Asp Arg 
            100                 105                 110         

Gln Ile Ala Glu Lys Asp Lys Gln Leu Asp Gln Gln Gln Gln Leu Thr 
        115                 120                 125             

Leu Gln Ala Met Lys Asp Gln Glu Asn Leu Lys Leu Glu Leu Asp Gln 
    130                 135                 140                 

Ala Lys Glu Glu Val Gln Ser Thr Lys Lys Gly Phe Phe Ala Arg Leu 
145                 150                 155                 160 

Phe Gly Gly 
            

<210>   1961
<211>   624
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1961
ttgattagaa cagagacagt agaggagagg tacagaatgg aacgattaga agattacatt   60
gcttttgatt tagaatttaa tcagcacgaa ggacaaacac acttgattca agtatcggca   120
gtgcgtttta gagatggtcg ggaaatcgat gcctatgatt cctatgttca taccagcgtc   180
cctctaaaaa gctttatcaa tggtttgacc gggattacag ctgagacctt aaaagatgct   240
cctccagttg agaaagtctt agaagaattc caagagtttg tgggttcttt gctgatgata   300
ggctacaatg ctgctaaaag tgatttacct attttagcag agcatggttt agactatagc   360
caacagtaca aggtggattt gtatgatgaa gcttttgaac gtcggagttc agatttacat   420
ggtattgcca atctcaaatt gcaaactgtt gcctcatttc ttggatttca aggtcagtct   480
cataatagtt tagaggatgc tcggatgacg gcgcgtgttt acgaatcctt cttagagtcg   540
gatcaagcta gggaattgtt agagacagaa agtagcttat caaacaatcc ttttggtggc   600
ttggacttgt ctcaattatt tgac                                          624

<210>   1962
<211>   208
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   exonuclease
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902940 (e-109)

<400>   1962
Met Ile Arg Thr Glu Thr Val Glu Glu Arg Tyr Arg Met Glu Arg Leu 
1               5                   10                  15      

Glu Asp Tyr Ile Ala Phe Asp Leu Glu Phe Asn Gln His Glu Gly Gln 
            20                  25                  30          

Thr His Leu Ile Gln Val Ser Ala Val Arg Phe Arg Asp Gly Arg Glu 
        35                  40                  45              

Ile Asp Ala Tyr Asp Ser Tyr Val His Thr Ser Val Pro Leu Lys Ser 
    50                  55                  60                  

Phe Ile Asn Gly Leu Thr Gly Ile Thr Ala Glu Thr Leu Lys Asp Ala 
65                  70                  75                  80  

Pro Pro Val Glu Lys Val Leu Glu Glu Phe Gln Glu Phe Val Gly Ser 
                85                  90                  95      

Leu Leu Met Ile Gly Tyr Asn Ala Ala Lys Ser Asp Leu Pro Ile Leu 
            100                 105                 110         

Ala Glu His Gly Leu Asp Tyr Ser Gln Gln Tyr Lys Val Asp Leu Tyr 
        115                 120                 125             

Asp Glu Ala Phe Glu Arg Arg Ser Ser Asp Leu His Gly Ile Ala Asn 
    130                 135                 140                 

Leu Lys Leu Gln Thr Val Ala Ser Phe Leu Gly Phe Gln Gly Gln Ser 
145                 150                 155                 160 

His Asn Ser Leu Glu Asp Ala Arg Met Thr Ala Arg Val Tyr Glu Ser 
                165                 170                 175     

Phe Leu Glu Ser Asp Gln Ala Arg Glu Leu Leu Glu Thr Glu Ser Ser 
            180                 185                 190         

Leu Ser Asn Asn Pro Phe Gly Gly Leu Asp Leu Ser Gln Leu Phe Asp 
        195                 200                 205             


<210>   1963
<211>   1767
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1963
gtgcctatga aacctgaaaa acctaaaaaa ttgggtctta aacagattta cctcgatctt   60
gataaaatcc tctttctatt tttcttgatt tttatgatag tggagtattt gtgggtacca   120
ttcaattcat ggttggctag cttcttatta gatcagacag gttatctttt tatttcctat   180
aacaatgtct tagccatcct tactcattct ccattgatta gtctagcttt tttagccttg   240
attgtaatta accttctggt tgcttatttt caaataggac tcctctttat tggtgctcgt   300
catctcctct ataatgaaaa gcgaaggcta attgagtata tccgcaaggt tttccatgaa   360
agttttggat ttatgaaaaa gctaacttgc gctaaagcct tgtttatctt tttctatata   420
gctatgctgt ttccttttat acggaaaatg ctgaagattt attatcttaa taaaatcgtc   480
attccagagt ttatccaagc ttatttagaa gatagatatt ggatgtggtg gctgagcatc   540
ctacttctat ctcttatctt tctctatgtc tctgtcagat tgatgtttgc ccttccgaag   600
attgtatatg atcagctgac tgttcgagaa gcagtgatgt ttagcttgga gaaaaccaag   660
aagagagtta ctttttatgc ttggaattta ttttacatct tgctcaaagc acatttatta   720
ttttatcttc ctttgattcc tttattattg gctcaaactt tggtagatga tatcactcag   780
agagagtctc tgattcttgg tattttgaat tttgtcgtga ttaaaaatct ctattatatg   840
gctctgactt attttttggt taaatttgtt tcatttttga caggaaagga gctggatatg   900
cttcctagga gagaaaaaga tcacatcgtg cgatggggtg tcatgacttg tgccagtctt   960
ttctttgcct tagaaggtta tatttatctg gaggctccca tggttcatct acctcaactt   1020
atttctcacc gaggggtttc caatgcaaat gggattcaaa atacagtaga gtccttggaa   1080
actacagcac aactcaaacc agacttggtg gagacggacg tgcaggaaac aaaagatggg   1140
cagtttgtca tgatgcatga tgctaacttg aaaaatctag caggtatcaa taaaagtcct   1200
caagacttaa acttggagga gcttaaaggg attgatattt ttgaaaatgg ctaccagact   1260
aaaatttcaa gctttgaaga ttatctcagt cgagccaacg aacttggtca aaaattacta   1320
attgaaatta aaaccagtaa aaaagatagt ccagacatga tgaaccgctt tttagcccgt   1380
tatgctgcaa agctcaagat ttatggacat caaatccagt ctttagacta ccatgttgtc   1440
gaaaaagtaa gacagtatga tgccgaacta ccagtttatt tcatcatgcc ctacaattct   1500
gtctttccta aaacaagagc gacaggatat actatggagt actcaacctt ggatgaatat   1560
tttgtaagca aactatggac aacggatcag aaactttatg tctggactgt caatgattca   1620
gaagctatca gcaaatctct tcacttagga gtagatggag tgattacaga tgatttggaa   1680
aaagttcagc gggaaataga agtagcccaa gaagatccag aatatacgga tttgctcttg   1740
aaaaaagcat tggaattctt tgaattt                                       1767

<210>   1964
<211>   589
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902941 (0.E+01)

<400>   1964
Met Pro Met Lys Pro Glu Lys Pro Lys Lys Leu Gly Leu Lys Gln Ile 
1               5                   10                  15      

Tyr Leu Asp Leu Asp Lys Ile Leu Phe Leu Phe Phe Leu Ile Phe Met 
            20                  25                  30          

Ile Val Glu Tyr Leu Trp Val Pro Phe Asn Ser Trp Leu Ala Ser Phe 
        35                  40                  45              

Leu Leu Asp Gln Thr Gly Tyr Leu Phe Ile Ser Tyr Asn Asn Val Leu 
    50                  55                  60                  

Ala Ile Leu Thr His Ser Pro Leu Ile Ser Leu Ala Phe Leu Ala Leu 
65                  70                  75                  80  

Ile Val Ile Asn Leu Leu Val Ala Tyr Phe Gln Ile Gly Leu Leu Phe 
                85                  90                  95      

Ile Gly Ala Arg His Leu Leu Tyr Asn Glu Lys Arg Arg Leu Ile Glu 
            100                 105                 110         

Tyr Ile Arg Lys Val Phe His Glu Ser Phe Gly Phe Met Lys Lys Leu 
        115                 120                 125             

Thr Cys Ala Lys Ala Leu Phe Ile Phe Phe Tyr Ile Ala Met Leu Phe 
    130                 135                 140                 

Pro Phe Ile Arg Lys Met Leu Lys Ile Tyr Tyr Leu Asn Lys Ile Val 
145                 150                 155                 160 

Ile Pro Glu Phe Ile Gln Ala Tyr Leu Glu Asp Arg Tyr Trp Met Trp 
                165                 170                 175     

Trp Leu Ser Ile Leu Leu Leu Ser Leu Ile Phe Leu Tyr Val Ser Val 
            180                 185                 190         

Arg Leu Met Phe Ala Leu Pro Lys Ile Val Tyr Asp Gln Leu Thr Val 
        195                 200                 205             

Arg Glu Ala Val Met Phe Ser Leu Glu Lys Thr Lys Lys Arg Val Thr 
    210                 215                 220                 

Phe Tyr Ala Trp Asn Leu Phe Tyr Ile Leu Leu Lys Ala His Leu Leu 
225                 230                 235                 240 

Phe Tyr Leu Pro Leu Ile Pro Leu Leu Leu Ala Gln Thr Leu Val Asp 
                245                 250                 255     

Asp Ile Thr Gln Arg Glu Ser Leu Ile Leu Gly Ile Leu Asn Phe Val 
            260                 265                 270         

Val Ile Lys Asn Leu Tyr Tyr Met Ala Leu Thr Tyr Phe Leu Val Lys 
        275                 280                 285             

Phe Val Ser Phe Leu Thr Gly Lys Glu Leu Asp Met Leu Pro Arg Arg 
    290                 295                 300                 

Glu Lys Asp His Ile Val Arg Trp Gly Val Met Thr Cys Ala Ser Leu 
305                 310                 315                 320 

Phe Phe Ala Leu Glu Gly Tyr Ile Tyr Leu Glu Ala Pro Met Val His 
                325                 330                 335     

Leu Pro Gln Leu Ile Ser His Arg Gly Val Ser Asn Ala Asn Gly Ile 
            340                 345                 350         

Gln Asn Thr Val Glu Ser Leu Glu Thr Thr Ala Gln Leu Lys Pro Asp 
        355                 360                 365             

Leu Val Glu Thr Asp Val Gln Glu Thr Lys Asp Gly Gln Phe Val Met 
    370                 375                 380                 

Met His Asp Ala Asn Leu Lys Asn Leu Ala Gly Ile Asn Lys Ser Pro 
385                 390                 395                 400 

Gln Asp Leu Asn Leu Glu Glu Leu Lys Gly Ile Asp Ile Phe Glu Asn 
                405                 410                 415     

Gly Tyr Gln Thr Lys Ile Ser Ser Phe Glu Asp Tyr Leu Ser Arg Ala 
            420                 425                 430         

Asn Glu Leu Gly Gln Lys Leu Leu Ile Glu Ile Lys Thr Ser Lys Lys 
        435                 440                 445             

Asp Ser Pro Asp Met Met Asn Arg Phe Leu Ala Arg Tyr Ala Ala Lys 
    450                 455                 460                 

Leu Lys Ile Tyr Gly His Gln Ile Gln Ser Leu Asp Tyr His Val Val 
465                 470                 475                 480 

Glu Lys Val Arg Gln Tyr Asp Ala Glu Leu Pro Val Tyr Phe Ile Met 
                485                 490                 495     

Pro Tyr Asn Ser Val Phe Pro Lys Thr Arg Ala Thr Gly Tyr Thr Met 
            500                 505                 510         

Glu Tyr Ser Thr Leu Asp Glu Tyr Phe Val Ser Lys Leu Trp Thr Thr 
        515                 520                 525             

Asp Gln Lys Leu Tyr Val Trp Thr Val Asn Asp Ser Glu Ala Ile Ser 
    530                 535                 540                 

Lys Ser Leu His Leu Gly Val Asp Gly Val Ile Thr Asp Asp Leu Glu 
545                 550                 555                 560 

Lys Val Gln Arg Glu Ile Glu Val Ala Gln Glu Asp Pro Glu Tyr Thr 
                565                 570                 575     

Asp Leu Leu Leu Lys Lys Ala Leu Glu Phe Phe Glu Phe 
            580                 585                 

<210>   1965
<211>   171
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1965
ttggttttgt tccttttact tggtggttta gctctcctgt tttctctttt agctttaacc   60
agccataaat ggtattacgt gagatttgga aaacgtgtga tgcttctgtt atactaccta   120
ttcgctcaca ataagagaga acttttttac gaaaatctat tgaatatgcc a            171

<210>   1966
<211>   57
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1966
Met Val Leu Phe Leu Leu Leu Gly Gly Leu Ala Leu Leu Phe Ser Leu 
1               5                   10                  15      

Leu Ala Leu Thr Ser His Lys Trp Tyr Tyr Val Arg Phe Gly Lys Arg 
            20                  25                  30          

Val Met Leu Leu Leu Tyr Tyr Leu Phe Ala His Asn Lys Arg Glu Leu 
        35                  40                  45              

Phe Tyr Glu Asn Leu Leu Asn Met Pro 
    50                  55          

<210>   1967
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1967
atgtggtata atcttcttat ggcatattca atagattttc gtaaaaaagt tctctcttat   60
tgtgagcgaa taggtagtat aacagaagca tcacacgttt tccaaatctc acgtaatacc   120
atttatggct ggttaaagct aaaagagaaa acaggagagc taaaccacca agtaaaagga   180
acaaaaccaa gaaaagttga tagagataga cttaaaaact atcttactga caatccagat   240
gcttatttga ctgaaatagc ttctgacttt ggctgtcatc caactaccat ccactatgcg   300
ctcaaagcta tgggctacac tcgaaaaaaa gaaccacacc tacta                   345

<210>   1968
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1 FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902766 (1.E-65)

<400>   1968
Met Trp Tyr Asn Leu Leu Met Ala Tyr Ser Ile Asp Phe Arg Lys Lys 
1               5                   10                  15      

Val Leu Ser Tyr Cys Glu Arg Ile Gly Ser Ile Thr Glu Ala Ser His 
            20                  25                  30          

Val Phe Gln Ile Ser Arg Asn Thr Ile Tyr Gly Trp Leu Lys Leu Lys 
        35                  40                  45              

Glu Lys Thr Gly Glu Leu Asn His Gln Val Lys Gly Thr Lys Pro Arg 
    50                  55                  60                  

Lys Val Asp Arg Asp Arg Leu Lys Asn Tyr Leu Thr Asp Asn Pro Asp 
65                  70                  75                  80  

Ala Tyr Leu Thr Glu Ile Ala Ser Asp Phe Gly Cys His Pro Thr Thr 
                85                  90                  95      

Ile His Tyr Ala Leu Lys Ala Met Gly Tyr Thr Arg Lys Lys Glu Pro 
            100                 105                 110         

His Leu Leu 
        115 

<210>   1969
<211>   138
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1969
ttggttgcag gtctaacaaa tggtgaatta atcgctccaa tgacttacga agagacgatg   60
acgagcgact tttttgaagc ttggtttcag aagtttctct taccaacatt aaccacacca   120
tcggttatta tagtaaaa                                                 138

<210>   1970
<211>   46
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf2, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903081 (6.E-21)

<400>   1970
Met Val Ala Gly Leu Thr Asn Gly Glu Leu Ile Ala Pro Met Thr Tyr 
1               5                   10                  15      

Glu Glu Thr Met Thr Ser Asp Phe Phe Glu Ala Trp Phe Gln Lys Phe 
            20                  25                  30          

Leu Leu Pro Thr Leu Thr Thr Pro Ser Val Ile Ile Val Lys 
        35                  40                  45      

<210>   1971
<211>   198
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1971
gtggtagcaa gcgcttcggc tagctcaacg agcacacaag ctcaagagca agttgacaag   60
tctgaacttc gtgccttgag tcaagagtta gaccaacgct tgaaagcttt ggcaacagta   120
tctgatccga aaatcgatgc aaccaaggct gtcctcctag atgctcaaaa agctccggaa   180
gatagtgcct tgacagag                                                 198

<210>   1972
<211>   66
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   hypothetical protein
<223>   Similar to strain R6 sequence 15902944 (2.E-30)

<400>   1972
Met Val Ala Ser Ala Ser Ala Ser Ser Thr Ser Thr Gln Ala Gln Glu 
1               5                   10                  15      

Gln Val Asp Lys Ser Glu Leu Arg Ala Leu Ser Gln Glu Leu Asp Gln 
            20                  25                  30          

Arg Leu Lys Ala Leu Ala Thr Val Ser Asp Pro Lys Ile Asp Ala Thr 
        35                  40                  45              

Lys Ala Val Leu Leu Asp Ala Gln Lys Ala Pro Glu Asp Ser Ala Leu 
    50                  55                  60                  

Thr Glu 
65      

<210>   1973
<211>   297
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1973
atgactgaaa caaactcagt tccggcagga gtgattgtgg tcagtctact tgccctccta   60
ggcgtgattg ccttctggct gattcgccgt aagaaagagt cagaaatcca gcaattaagc   120
acggaattga tcaaggttct aggacagcta gatgcagaaa aagcggataa aaaagtcctt   180
gccaaagccc aaaaccttct ccaagaaacc cttgatttcg tgaaagaaga aaatggctca   240
gcagagacag aaactaaact agtagaggag cttaaagcaa tccttgacaa actcaag      297

<210>   1974
<211>   99
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902946 (3.E-49)

<400>   1974
Met Thr Glu Thr Asn Ser Val Pro Ala Gly Val Ile Val Val Ser Leu 
1               5                   10                  15      

Leu Ala Leu Leu Gly Val Ile Ala Phe Trp Leu Ile Arg Arg Lys Lys 
            20                  25                  30          

Glu Ser Glu Ile Gln Gln Leu Ser Thr Glu Leu Ile Lys Val Leu Gly 
        35                  40                  45              

Gln Leu Asp Ala Glu Lys Ala Asp Lys Lys Val Leu Ala Lys Ala Gln 
    50                  55                  60                  

Asn Leu Leu Gln Glu Thr Leu Asp Phe Val Lys Glu Glu Asn Gly Ser 
65                  70                  75                  80  

Ala Glu Thr Glu Thr Lys Leu Val Glu Glu Leu Lys Ala Ile Leu Asp 
                85                  90                  95      

Lys Leu Lys 
            

<210>   1975
<211>   630
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1975
atgttttact tgagtttgtc aaggattgct ttaagctcct ctactagttt agtttctgtc   60
tctgctgagc cattttcttc tttcacgaaa tcaagggttt cttggagaag gttttgggct   120
ttggcaagga cttttttatc cgctttttct gcatctagct gtcctagaac cttgatcaat   180
tccgtgctta attgctggat ttctgactct ttcttacggc gaatcagcca gaaggcaatc   240
acgcctagga gggcaagtag actgaccaca atcactcctg ccggaactga gtttgtttca   300
gtcatcttat ctgaatcctt actatcttcc gttccttgtt ttgcatcctt cttgtcctgt   360
gcaggcttgc tgtcgctagc atttgctttc acatctttga gagagtccaa ggcagcccag   420
ccttcacaga ctctactgca gtatgcagac cttactctgt caaggcacta tcttccggag   480
ctttttgagc atctaggagg acagccttgg ttgcatcgat tttcggatca gatactgttg   540
ccaaagcttt caagcgttgg tctaactctt gactcaaggc acgaagttca gacttgtcaa   600
cttgctcttg agcttgtgtg ctcgttgagc                                    630

<210>   1976
<211>   210
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1976
Met Phe Tyr Leu Ser Leu Ser Arg Ile Ala Leu Ser Ser Ser Thr Ser 
1               5                   10                  15      

Leu Val Ser Val Ser Ala Glu Pro Phe Ser Ser Phe Thr Lys Ser Arg 
            20                  25                  30          

Val Ser Trp Arg Arg Phe Trp Ala Leu Ala Arg Thr Phe Leu Ser Ala 
        35                  40                  45              

Phe Ser Ala Ser Ser Cys Pro Arg Thr Leu Ile Asn Ser Val Leu Asn 
    50                  55                  60                  

Cys Trp Ile Ser Asp Ser Phe Leu Arg Arg Ile Ser Gln Lys Ala Ile 
65                  70                  75                  80  

Thr Pro Arg Arg Ala Ser Arg Leu Thr Thr Ile Thr Pro Ala Gly Thr 
                85                  90                  95      

Glu Phe Val Ser Val Ile Leu Ser Glu Ser Leu Leu Ser Ser Val Pro 
            100                 105                 110         

Cys Phe Ala Ser Phe Leu Ser Cys Ala Gly Leu Leu Ser Leu Ala Phe 
        115                 120                 125             

Ala Phe Thr Ser Leu Arg Glu Ser Lys Ala Ala Gln Pro Ser Gln Thr 
    130                 135                 140                 

Leu Leu Gln Tyr Ala Asp Leu Thr Leu Ser Arg His Tyr Leu Pro Glu 
145                 150                 155                 160 

Leu Phe Glu His Leu Gly Gly Gln Pro Trp Leu His Arg Phe Ser Asp 
                165                 170                 175     

Gln Ile Leu Leu Pro Lys Leu Ser Ser Val Gly Leu Thr Leu Asp Ser 
            180                 185                 190         

Arg His Glu Val Gln Thr Cys Gln Leu Ala Leu Glu Leu Val Cys Ser 
        195                 200                 205             

Leu Ser 
    210 

<210>   1977
<211>   705
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1977
ttggaaacga tagtattttt aatctctgtt tttctagcag gtgttttatc ctttttttct   60
ccttgtattt ttcctcttct gccagtctat gctgggattt tattggatga tcaagaaagt   120
gcaaaaagct tttctttgtt tgggagaaag gttctctggt caggcttgat tcgaacactt   180
tgctttatcg ctggtatctc tctcattttc tttattctag gctttggtgc tggttacttt   240
ggtcatattc tctatgcaaa ttggtttcga tatggcatgg gagctattat tatcattttg   300
ggtcttcacc agatggaaat ttttcatttg aagaaattag aagttcaaaa aagttttacc   360
tttaaaaaat cagattctaa tcgttattgg tcagcttttt tacttggtat tacctttagc   420
tttggttgga caccttgtat tggtccagtt ttaagttctg ttttagcact tgcggcttct   480
ggaggcaatg gcgcttggca aggagcgatt tatactctca tttacactct gggcatggcc   540
cttcctttct tggtattggc actagcttca ggtctagtca tgccatattt tagtaaaatc   600
aagcgtcata tgatgctact aaagaaaatt ggtggtttcc tcattgtttt aatgggaatt   660
ttgttactat taggacaagt aaatgttcta gctggaattt ttgaa                   705

<210>   1978
<211>   235
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cytochrome c-type biogenesis protein CcdA (ccdA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902947 (e-132)

<400>   1978
Met Glu Thr Ile Val Phe Leu Ile Ser Val Phe Leu Ala Gly Val Leu 
1               5                   10                  15      

Ser Phe Phe Ser Pro Cys Ile Phe Pro Leu Leu Pro Val Tyr Ala Gly 
            20                  25                  30          

Ile Leu Leu Asp Asp Gln Glu Ser Ala Lys Ser Phe Ser Leu Phe Gly 
        35                  40                  45              

Arg Lys Val Leu Trp Ser Gly Leu Ile Arg Thr Leu Cys Phe Ile Ala 
    50                  55                  60                  

Gly Ile Ser Leu Ile Phe Phe Ile Leu Gly Phe Gly Ala Gly Tyr Phe 
65                  70                  75                  80  

Gly His Ile Leu Tyr Ala Asn Trp Phe Arg Tyr Gly Met Gly Ala Ile 
                85                  90                  95      

Ile Ile Ile Leu Gly Leu His Gln Met Glu Ile Phe His Leu Lys Lys 
            100                 105                 110         

Leu Glu Val Gln Lys Ser Phe Thr Phe Lys Lys Ser Asp Ser Asn Arg 
        115                 120                 125             

Tyr Trp Ser Ala Phe Leu Leu Gly Ile Thr Phe Ser Phe Gly Trp Thr 
    130                 135                 140                 

Pro Cys Ile Gly Pro Val Leu Ser Ser Val Leu Ala Leu Ala Ala Ser 
145                 150                 155                 160 

Gly Gly Asn Gly Ala Trp Gln Gly Ala Ile Tyr Thr Leu Ile Tyr Thr 
                165                 170                 175     

Leu Gly Met Ala Leu Pro Phe Leu Val Leu Ala Leu Ala Ser Gly Leu 
            180                 185                 190         

Val Met Pro Tyr Phe Ser Lys Ile Lys Arg His Met Met Leu Leu Lys 
        195                 200                 205             

Lys Ile Gly Gly Phe Leu Ile Val Leu Met Gly Ile Leu Leu Leu Leu 
    210                 215                 220                 

Gly Gln Val Asn Val Leu Ala Gly Ile Phe Glu 
225                 230                 235 

<210>   1979
<211>   555
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1979
atgaaaaaag taatgtttgc tggcttaagt ctcttgtcat tagttgtatt gatggcctgt   60
ggtgaggaag aaactaaaaa gactcaagca gcacaacagc caaaacaaca aacgactgta   120
caacaaattg ctgttggaaa agatgctcca gacttcacat tgcaatccat ggatggcaaa   180
gaagttaagt tatctgattt taagggtaaa aaggtttact tgaagttttg ggcttcatgg   240
tgtggtccat gcaagaaaag tatgccagag ttgatggaac tagcggcgaa accagatcgt   300
gatttcgaaa ttcttactgt cattgcacca ggaattcaag gtgaaaaaac tgttgagcaa   360
ttcccacaat ggttccagga acaaggatat aaggatatcc cagttcttta tgataccaaa   420
gcaaccacct tccaagctta tcaaattcga agcattccta cagaatattt aattgatagc   480
caaggaaaga ttggaaagat tcaatttggt gctatcagta atgcggatgc agaagcagca   540
tttaaagaaa tgaac                                                    555

<210>   1980
<211>   185
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thioredoxin family protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902948 (e-104)

<400>   1980
Met Lys Lys Val Met Phe Ala Gly Leu Ser Leu Leu Ser Leu Val Val 
1               5                   10                  15      

Leu Met Ala Cys Gly Glu Glu Glu Thr Lys Lys Thr Gln Ala Ala Gln 
            20                  25                  30          

Gln Pro Lys Gln Gln Thr Thr Val Gln Gln Ile Ala Val Gly Lys Asp 
        35                  40                  45              

Ala Pro Asp Phe Thr Leu Gln Ser Met Asp Gly Lys Glu Val Lys Leu 
    50                  55                  60                  

Ser Asp Phe Lys Gly Lys Lys Val Tyr Leu Lys Phe Trp Ala Ser Trp 
65                  70                  75                  80  

Cys Gly Pro Cys Lys Lys Ser Met Pro Glu Leu Met Glu Leu Ala Ala 
                85                  90                  95      

Lys Pro Asp Arg Asp Phe Glu Ile Leu Thr Val Ile Ala Pro Gly Ile 
            100                 105                 110         

Gln Gly Glu Lys Thr Val Glu Gln Phe Pro Gln Trp Phe Gln Glu Gln 
        115                 120                 125             

Gly Tyr Lys Asp Ile Pro Val Leu Tyr Asp Thr Lys Ala Thr Thr Phe 
    130                 135                 140                 

Gln Ala Tyr Gln Ile Arg Ser Ile Pro Thr Glu Tyr Leu Ile Asp Ser 
145                 150                 155                 160 

Gln Gly Lys Ile Gly Lys Ile Gln Phe Gly Ala Ile Ser Asn Ala Asp 
                165                 170                 175     

Ala Glu Ala Ala Phe Lys Glu Met Asn 
            180                 185 

<210>   1981
<211>   1389
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1981
atgaatatat ttagaacaaa gaatgttagt ttagataaaa cagagatgca taggcatttg   60
aagttatggg atttgatttt gctgggtatc ggagccatgg tagggacagg cgtctttaca   120
atcacaggta ctgcagctgc aacacttgct ggcccagccc tagtgatttc aatcgttatt   180
tctgccttgt gtgtgggatt atcagccctc ttttttgcag aatttgcctc gcgagtaccc   240
gctacaggag gtgcctatag ttacctctat gctatcttag gagaattccc tgcctggttg   300
gctggttggt taaccatgat ggagttcatg acagccatat caggcgtagc ttcgggttgg   360
gcagcttatt ttaaaggctt gctctctcaa tacgggatag cctttcctca ggctttaaat   420
ggtaccttta atcctcaagc agggacattt gttgatttat tgcctattct tgtcttggtc   480
ttggtgactt cgcttgtttt actaaatgcc aaggcagcct tacgctttaa ttcgattcta   540
gttattttga aattttccgc tttagctctc tttgttttag taggaatttg gaatattaag   600
tttgataatt ggagcaattt tgctccttac ggttttggac aaatctatgg agctagcact   660
ggtattatgg ctggtgcgtc cttgatgttc ttcggttttt tgggatttga atccatctct   720
atggctgtag atgaagtcaa gactcctcaa aaaaatattc ctagagggat tgtcttatcg   780
ctttctatcg taaccattct ctatgccttg gtgacccttg ttttgactgg tgtggttcac   840
tatagtcatt taaatgtcga tgatgccgtt gcctttgccc ttcgtagtgt tgggattagt   900
tgggcagcca actatgtgtc attagtggct atcttgacct tgattacagt ttgtatttcg   960
atgacctatg ccctatcgcg tatgatttac agtttagcac gtgacggctt agtgcctgct   1020
gcctttaagg aactgacgaa gactagcaag ataccaaaga atgctactat cttgacaggt   1080
ctagcttcag cagtagcagc aggaatgttc ccactagcca gtattgcagc ctttttaaat   1140
atttgtacct tagcctactt gatcatgttg gcttatggtc tgattcgctt acggaaagaa   1200
aaaggaatgc ccaaagctgg ggaatttaaa acaccattgg tacctctgtt accaatttta   1260
tcgatcatca tttgtttatc cttcatgtta cagtataata tgaatacctg gattgctttc   1320
ctagttgcgt tgttagtagg aagtattatt tacttcactt atggctataa gcattctacc   1380
atagaagaa                                                           1389

<210>   1982
<211>   463
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid permease family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902949 (0.E+01)

<400>   1982
Met Asn Ile Phe Arg Thr Lys Asn Val Ser Leu Asp Lys Thr Glu Met 
1               5                   10                  15      

His Arg His Leu Lys Leu Trp Asp Leu Ile Leu Leu Gly Ile Gly Ala 
            20                  25                  30          

Met Val Gly Thr Gly Val Phe Thr Ile Thr Gly Thr Ala Ala Ala Thr 
        35                  40                  45              

Leu Ala Gly Pro Ala Leu Val Ile Ser Ile Val Ile Ser Ala Leu Cys 
    50                  55                  60                  

Val Gly Leu Ser Ala Leu Phe Phe Ala Glu Phe Ala Ser Arg Val Pro 
65                  70                  75                  80  

Ala Thr Gly Gly Ala Tyr Ser Tyr Leu Tyr Ala Ile Leu Gly Glu Phe 
                85                  90                  95      

Pro Ala Trp Leu Ala Gly Trp Leu Thr Met Met Glu Phe Met Thr Ala 
            100                 105                 110         

Ile Ser Gly Val Ala Ser Gly Trp Ala Ala Tyr Phe Lys Gly Leu Leu 
        115                 120                 125             

Ser Gln Tyr Gly Ile Ala Phe Pro Gln Ala Leu Asn Gly Thr Phe Asn 
    130                 135                 140                 

Pro Gln Ala Gly Thr Phe Val Asp Leu Leu Pro Ile Leu Val Leu Val 
145                 150                 155                 160 

Leu Val Thr Ser Leu Val Leu Leu Asn Ala Lys Ala Ala Leu Arg Phe 
                165                 170                 175     

Asn Ser Ile Leu Val Ile Leu Lys Phe Ser Ala Leu Ala Leu Phe Val 
            180                 185                 190         

Leu Val Gly Ile Trp Asn Ile Lys Phe Asp Asn Trp Ser Asn Phe Ala 
        195                 200                 205             

Pro Tyr Gly Phe Gly Gln Ile Tyr Gly Ala Ser Thr Gly Ile Met Ala 
    210                 215                 220                 

Gly Ala Ser Leu Met Phe Phe Gly Phe Leu Gly Phe Glu Ser Ile Ser 
225                 230                 235                 240 

Met Ala Val Asp Glu Val Lys Thr Pro Gln Lys Asn Ile Pro Arg Gly 
                245                 250                 255     

Ile Val Leu Ser Leu Ser Ile Val Thr Ile Leu Tyr Ala Leu Val Thr 
            260                 265                 270         

Leu Val Leu Thr Gly Val Val His Tyr Ser His Leu Asn Val Asp Asp 
        275                 280                 285             

Ala Val Ala Phe Ala Leu Arg Ser Val Gly Ile Ser Trp Ala Ala Asn 
    290                 295                 300                 

Tyr Val Ser Leu Val Ala Ile Leu Thr Leu Ile Thr Val Cys Ile Ser 
305                 310                 315                 320 

Met Thr Tyr Ala Leu Ser Arg Met Ile Tyr Ser Leu Ala Arg Asp Gly 
                325                 330                 335     

Leu Val Pro Ala Ala Phe Lys Glu Leu Thr Lys Thr Ser Lys Ile Pro 
            340                 345                 350         

Lys Asn Ala Thr Ile Leu Thr Gly Leu Ala Ser Ala Val Ala Ala Gly 
        355                 360                 365             

Met Phe Pro Leu Ala Ser Ile Ala Ala Phe Leu Asn Ile Cys Thr Leu 
    370                 375                 380                 

Ala Tyr Leu Ile Met Leu Ala Tyr Gly Leu Ile Arg Leu Arg Lys Glu 
385                 390                 395                 400 

Lys Gly Met Pro Lys Ala Gly Glu Phe Lys Thr Pro Leu Val Pro Leu 
                405                 410                 415     

Leu Pro Ile Leu Ser Ile Ile Ile Cys Leu Ser Phe Met Leu Gln Tyr 
            420                 425                 430         

Asn Met Asn Thr Trp Ile Ala Phe Leu Val Ala Leu Leu Val Gly Ser 
        435                 440                 445             

Ile Ile Tyr Phe Thr Tyr Gly Tyr Lys His Ser Thr Ile Glu Glu 
    450                 455                 460             

<210>   1983
<211>   933
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1983
atggttaagg agttgttcat gaagaaacaa aatttatttt tagtcctgtt aagtgtcttt   60
cttttgtgct tgggggcttg tggtcaaaag gaaagtcaga caggaaaggg gatgaaaatt   120
gtgaccagtt tttatcctat ctacgctatg gttaaggaag tatctggtga cttgaatgat   180
gttcggatga ttcagtcaag tagtggtatt cactcctttg aaccttcggc aaatgatatc   240
gcagccatct atgatgcaga tgtctttgtt taccattctc atacactcga atcttgggca   300
ggaagtctgg atccaaatct aaaaaaatcc aaagtgaagg tcttagaggc ttctgaggga   360
atgaccttgg aacgtgtccc tggactagag gatgtggaag caggggatgg agttgatgaa   420
aaaacgctct atgaccctca cacatggcta gatcctgaaa aagctggaga agaagcccaa   480
attatcgctg ataaactttc agaggtggat agtgagcata aagagactta tcaaaaaaat   540
gcgcaagcct ttatcaaaaa agctcaggaa ttgactaaga aattccaacc aaaatttgaa   600
aaagcgactc agaaaacatt tgtaacacaa catacagcct tttcttatct agcgaagaga   660
tttgggctta atcaacttgg tattgcaggt atctctcctg aacaagaacc aagtccacga   720
caactaacag aaattcagga atttgttaag acctataagg ttaaaacgat ttttacagaa   780
agtaacgctt cttcaaaagt agctgaaact cttgtcaaat caacaggtgt gggtcttaaa   840
actctgaatc ctttagagtc agacccacaa aatgacaaga cctatttaga aaatcttgaa   900
gaaaatatga gtattctagc agaagaatta aag                                933

<210>   1984
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   adhesion lipoprotein (lmb)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902950 (e-173)

<400>   1984
Met Val Lys Glu Leu Phe Met Lys Lys Gln Asn Leu Phe Leu Val Leu 
1               5                   10                  15      

Leu Ser Val Phe Leu Leu Cys Leu Gly Ala Cys Gly Gln Lys Glu Ser 
            20                  25                  30          

Gln Thr Gly Lys Gly Met Lys Ile Val Thr Ser Phe Tyr Pro Ile Tyr 
        35                  40                  45              

Ala Met Val Lys Glu Val Ser Gly Asp Leu Asn Asp Val Arg Met Ile 
    50                  55                  60                  

Gln Ser Ser Ser Gly Ile His Ser Phe Glu Pro Ser Ala Asn Asp Ile 
65                  70                  75                  80  

Ala Ala Ile Tyr Asp Ala Asp Val Phe Val Tyr His Ser His Thr Leu 
                85                  90                  95      

Glu Ser Trp Ala Gly Ser Leu Asp Pro Asn Leu Lys Lys Ser Lys Val 
            100                 105                 110         

Lys Val Leu Glu Ala Ser Glu Gly Met Thr Leu Glu Arg Val Pro Gly 
        115                 120                 125             

Leu Glu Asp Val Glu Ala Gly Asp Gly Val Asp Glu Lys Thr Leu Tyr 
    130                 135                 140                 

Asp Pro His Thr Trp Leu Asp Pro Glu Lys Ala Gly Glu Glu Ala Gln 
145                 150                 155                 160 

Ile Ile Ala Asp Lys Leu Ser Glu Val Asp Ser Glu His Lys Glu Thr 
                165                 170                 175     

Tyr Gln Lys Asn Ala Gln Ala Phe Ile Lys Lys Ala Gln Glu Leu Thr 
            180                 185                 190         

Lys Lys Phe Gln Pro Lys Phe Glu Lys Ala Thr Gln Lys Thr Phe Val 
        195                 200                 205             

Thr Gln His Thr Ala Phe Ser Tyr Leu Ala Lys Arg Phe Gly Leu Asn 
    210                 215                 220                 

Gln Leu Gly Ile Ala Gly Ile Ser Pro Glu Gln Glu Pro Ser Pro Arg 
225                 230                 235                 240 

Gln Leu Thr Glu Ile Gln Glu Phe Val Lys Thr Tyr Lys Val Lys Thr 
                245                 250                 255     

Ile Phe Thr Glu Ser Asn Ala Ser Ser Lys Val Ala Glu Thr Leu Val 
            260                 265                 270         

Lys Ser Thr Gly Val Gly Leu Lys Thr Leu Asn Pro Leu Glu Ser Asp 
        275                 280                 285             

Pro Gln Asn Asp Lys Thr Tyr Leu Glu Asn Leu Glu Glu Asn Met Ser 
    290                 295                 300                 

Ile Leu Ala Glu Glu Leu Lys 
305                 310     

<210>   1985
<211>   2517
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1985
atgaaaatta ataaaaaata tctagcaggt tcagtggcag tccttgccct aagtgtttgt   60
tcctatgaac ttggtcgtca ccaagctggt caggttaaga aagagtctaa tcgagtttct   120
tatatagatg gtgatcaggc tggtcaaaag gcagaaaact tgacaccaga tgaagtcagt   180
aagagggagg ggatcaacgc cgaacaaatc gtcatcaaga ttacggatca aggttatgtg   240
acctctcatg gagaccatta tcattactat aatggcaagg tcccttatga tgccatcatc   300
agtgaagagc tcctcatgaa agatccgaat tatcagttga aggattcaga cattgtcaat   360
gaaatcaagg gtggttatgt tatcaaggta gatggaaaat actatgttta ccttaaggat   420
gcagctcatg cggataatat tcggacaaaa gaagagatta aacgtcagaa gcaggaacac   480
agtcataatc acgggggtgg ttctaacgat caagcagtag ttgcagccag agcccaagga   540
cgctatacaa cggatgatgg ttatatcttc aatgcatctg atatcattga ggacacgggt   600
gatgcttata tcgttcctca cggcgaccat taccattaca ttcctaagaa tgagttatca   660
gctagcgagt tagctgctgc agaagcctat tggaatggga agcagggatc tcgtccttct   720
tcaagttcta gttataatgc aaatccagct caaccaagat tgtcagagaa ccacaatctg   780
actgtcactc caacttatca tcaaaatcaa ggggaaaaca tttcaagcct tttacgtgaa   840
ttgtatgcta aacccttatc agaacgccat gtggaatctg atggccttat tttcgaccca   900
gcgcaaatca caagtcgaac cgccagaggt gtagctgtcc ctcatggtaa ccattaccac   960
tttatccctt atgaacaaat gtctgaattg gaaaaacgaa ttgctcgtat tattcccctt   1020
cgttatcgtt caaaccattg ggtaccagat tcaagaccag aacaaccaag tccacaatcg   1080
actccggaac ctagtccaag tccgcaacct gcaccaaatc ctcaaccagc tccaagcaat   1140
ccaattgatg agaaattggt caaagaagct gttcgaaaag taggcgatgg ttatgtcttt   1200
gaggagaatg gagtttctcg ttatatccca gccaaggatc tttcagcaga aacagcagca   1260
ggcattgata gcaaactggc caagcaggaa agtttatctc ataagctagg agctaagaaa   1320
actgacctcc catctagtga tcgagaattt tacaataagg cttatgactt actagcaaga   1380
attcaccaag atttacttga taataaaggt cgacaagttg attttgaggc tttggataac   1440
ctgttggaac gactcaagga tgtcccaagt gataaagtca agttagtgga tgatattctt   1500
gccttcttag ctccgattcg tcatccagaa cgtttaggaa aaccaaatgc gcaaattacc   1560
tacactgatg atgagattca agtagccaag ttggcaggca agtacacaac agaagacggt   1620
tatatctttg atcctcgtga tataaccagt gatgaggggg atgcctatgt aactccacat   1680
atgacccata gccactggat taaaaaagat agtttgtctg aagctgagag agcggcagcc   1740
caggcttatg ctaaagagaa aggtttgacc cctccttcga cagaccatca ggattcagga   1800
aatactgagg caaaaggagc agaagctatc tacaaccgcg tgaaagcagc taagaaggtg   1860
ccacttgatc gtatgcctta caatcttcaa tatactgtag aagtcaaaaa cggtagttta   1920
atcatacctc attatgacca ttaccataac atcaaatttg agtggtttga cgaaggcctt   1980
tatgaggcac ctaaggggta tactcttgag gatcttttgg cgactgtcaa gtactatgtc   2040
gaacatccaa acgaacgtcc gcattcagat aatggttttg gtaacgctag cgaccatgtt   2100
cgtaaaaata aggtagacca agacagtaaa cctgatgaag ataaggaaca tgatgaagta   2160
agtgagccaa ctcaccctga atctgatgaa aaagagaatc acgctggttt aaatccttca   2220
gcagataatc tttataaacc aagcactgat acggaagaga cagaggaaga agctgaagat   2280
accacagatg aggctgaaat tcctcaagta gagaattctg ttattaacgc taagatagca   2340
gatgcggagg ccttgctaga aaaagtaaca gatcctagta ttagacaaaa tgctatggag   2400
acattgactg gtctaaaaag tagtcttctt ctcggaacga aagataataa cactatttca   2460
gcagaagtag atagtctctt ggctttgtta aaagaaagtc aaccggctcc tatacag      2517

<210>   1986
<211>   839
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (Pneumococcal histidine)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902951 (0.E+01)

<400>   1986
Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      

Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg His Gln Ala Gly Gln Val 
            20                  25                  30          

Lys Lys Glu Ser Asn Arg Val Ser Tyr Ile Asp Gly Asp Gln Ala Gly 
        35                  40                  45              

Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  

Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             

Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu His 
145                 150                 155                 160 

Ser His Asn His Gly Gly Gly Ser Asn Asp Gln Ala Val Val Ala Ala 
                165                 170                 175     

Arg Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala 
            180                 185                 190         

Ser Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly 
        195                 200                 205             

Asp His Tyr His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu 
    210                 215                 220                 

Ala Ala Ala Glu Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser 
225                 230                 235                 240 

Ser Ser Ser Ser Tyr Asn Ala Asn Pro Ala Gln Pro Arg Leu Ser Glu 
                245                 250                 255     

Asn His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu 
            260                 265                 270         

Asn Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu 
        275                 280                 285             

Arg His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr 
    290                 295                 300                 

Ser Arg Thr Ala Arg Gly Val Ala Val Pro His Gly Asn His Tyr His 
305                 310                 315                 320 

Phe Ile Pro Tyr Glu Gln Met Ser Glu Leu Glu Lys Arg Ile Ala Arg 
                325                 330                 335     

Ile Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg 
            340                 345                 350         

Pro Glu Gln Pro Ser Pro Gln Ser Thr Pro Glu Pro Ser Pro Ser Pro 
        355                 360                 365             

Gln Pro Ala Pro Asn Pro Gln Pro Ala Pro Ser Asn Pro Ile Asp Glu 
    370                 375                 380                 

Lys Leu Val Lys Glu Ala Val Arg Lys Val Gly Asp Gly Tyr Val Phe 
385                 390                 395                 400 

Glu Glu Asn Gly Val Ser Arg Tyr Ile Pro Ala Lys Asp Leu Ser Ala 
                405                 410                 415     

Glu Thr Ala Ala Gly Ile Asp Ser Lys Leu Ala Lys Gln Glu Ser Leu 
            420                 425                 430         

Ser His Lys Leu Gly Ala Lys Lys Thr Asp Leu Pro Ser Ser Asp Arg 
        435                 440                 445             

Glu Phe Tyr Asn Lys Ala Tyr Asp Leu Leu Ala Arg Ile His Gln Asp 
    450                 455                 460                 

Leu Leu Asp Asn Lys Gly Arg Gln Val Asp Phe Glu Ala Leu Asp Asn 
465                 470                 475                 480 

Leu Leu Glu Arg Leu Lys Asp Val Pro Ser Asp Lys Val Lys Leu Val 
                485                 490                 495     

Asp Asp Ile Leu Ala Phe Leu Ala Pro Ile Arg His Pro Glu Arg Leu 
            500                 505                 510         


Gly Lys Pro Asn Ala Gln Ile Thr Tyr Thr Asp Asp Glu Ile Gln Val 
        515                 520                 525             

Ala Lys Leu Ala Gly Lys Tyr Thr Thr Glu Asp Gly Tyr Ile Phe Asp 
    530                 535                 540                 

Pro Arg Asp Ile Thr Ser Asp Glu Gly Asp Ala Tyr Val Thr Pro His 
545                 550                 555                 560 

Met Thr His Ser His Trp Ile Lys Lys Asp Ser Leu Ser Glu Ala Glu 
                565                 570                 575     

Arg Ala Ala Ala Gln Ala Tyr Ala Lys Glu Lys Gly Leu Thr Pro Pro 
            580                 585                 590         

Ser Thr Asp His Gln Asp Ser Gly Asn Thr Glu Ala Lys Gly Ala Glu 
        595                 600                 605             

Ala Ile Tyr Asn Arg Val Lys Ala Ala Lys Lys Val Pro Leu Asp Arg 
    610                 615                 620                 

Met Pro Tyr Asn Leu Gln Tyr Thr Val Glu Val Lys Asn Gly Ser Leu 
625                 630                 635                 640 

Ile Ile Pro His Tyr Asp His Tyr His Asn Ile Lys Phe Glu Trp Phe 
                645                 650                 655     

Asp Glu Gly Leu Tyr Glu Ala Pro Lys Gly Tyr Thr Leu Glu Asp Leu 
            660                 665                 670         

Leu Ala Thr Val Lys Tyr Tyr Val Glu His Pro Asn Glu Arg Pro His 
        675                 680                 685             

Ser Asp Asn Gly Phe Gly Asn Ala Ser Asp His Val Arg Lys Asn Lys 
    690                 695                 700                 

Val Asp Gln Asp Ser Lys Pro Asp Glu Asp Lys Glu His Asp Glu Val 
705                 710                 715                 720 

Ser Glu Pro Thr His Pro Glu Ser Asp Glu Lys Glu Asn His Ala Gly 
                725                 730                 735     

Leu Asn Pro Ser Ala Asp Asn Leu Tyr Lys Pro Ser Thr Asp Thr Glu 
            740                 745                 750         

Glu Thr Glu Glu Glu Ala Glu Asp Thr Thr Asp Glu Ala Glu Ile Pro 
        755                 760                 765             

Gln Val Glu Asn Ser Val Ile Asn Ala Lys Ile Ala Asp Ala Glu Ala 
    770                 775                 780                 

Leu Leu Glu Lys Val Thr Asp Pro Ser Ile Arg Gln Asn Ala Met Glu 
785                 790                 795                 800 

Thr Leu Thr Gly Leu Lys Ser Ser Leu Leu Leu Gly Thr Lys Asp Asn 
                805                 810                 815     

Asn Thr Ile Ser Ala Glu Val Asp Ser Leu Leu Ala Leu Leu Lys Glu 
            820                 825                 830         

Ser Gln Pro Ala Pro Ile Gln 
        835                 

<210>   1987
<211>   3117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1987
atgaaattta gtaaaaaata tatagcagct ggatcagctg ttatcgtatc cttgagtcta   60
tgtgcctatg cactaaacca gcatcgttcg caggaaaata aggacaataa tcgtgtctct   120
tatgtggatg gcagccagtc aagtcagaaa agtgaaaact tgacaccaga ccaggttagc   180
cagaaagaag gaattcaggc tgagcaaatt gtaatcaaaa ttacagatca gggctatgta   240
acgtcacacg gtgaccacta tcattactat aatgggaaag ttccttatga tgccctcttt   300
agtgaagaac tcttgatgaa ggatccaaac tatcaactta aagacgctga tattgtcaat   360
gaagtcaagg gtggttatat catcaaggtc gatggaaaat attatgtcta cctgaaagat   420
gcagctcatg ctgataatgt tcgaactaaa gatgaaatca atcgtcaaaa acaagaacat   480
gtcaaagata atgagaaggt taactctaat gttgctgtag caaggtctca gggacgatat   540
acgacaaatg atggttatgt ctttaatcca gctgatatta tcgaagatac gggtaatgct   600
tatatcgttc ctcatggagg tcactatcac tacattccca aaagcgattt atctgctagt   660
gaattagcag cagctaaagc acatctggct ggaaaaaata tgcaaccgag tcagttaagc   720
tattcttcaa cagctagtga caataacacg caatctgtag caaaaggatc aactagcaag   780
ccagcaaata aatctgaaaa tctccagagt cttttgaagg aactctatga ttcacctagc   840
gcccaacgtt acagtgaatc agatggcctg gtctttgacc ctgctaagat tatcagtcgt   900
acaccaaatg gagttgcgat tccgcatggc gaccattacc actttattcc ttacagcaag   960
ctttctgcct tagaagaaaa gattgccaga atggtgccta tcagtggaac tggttctaca   1020
gtttctacaa atgcaaaacc taatgaagta gtgtctagtc taggcagtct ttcaagcaat   1080
ccttcttctt taacgacaag taaggagctc tcttcagcat ctgatggtta tatttttaat   1140
ccaaaagata tcgttgaaga aacggctaca gcttatattg taagacatgg tgatcatttc   1200
cattacattc caaaatcaaa tcaaattggg caaccgactc ttccaaacaa tagtctagca   1260
acaccttctc catctcttcc aatcaatcca ggaacttcac atgagaaaca tgaagaagat   1320
ggatacggat ttgatgctaa tcgtattatc gctgaagatg aatcaggttt tgtcatgagt   1380
cacggagacc acaatcatta tttcttcaag aaggacttga cagaagagca aattaaggct   1440
gcgcaaaaac atttagagga agttaaaact agtcataatg gattagattc tttgtcatct   1500
catgaacagg attatccaag taatgccaaa gaaatgaaag atttagataa aaaaatcgaa   1560
gaaaaaattg ctggcattat gaaacaatat ggtgtcaaac gtgaaagtat tgtcgtgaat   1620
aaagaaaaaa atgcgattat ttatccgcat ggagatcacc atcatgcaga tccgattgat   1680
gaacataaac cggttggaat tggtcattct cacagtaact atgaactgtt taaacccgaa   1740
gaaggagttg ctaaaaaaga agggaataaa gtttatactg gagaagaatt aacgaatgtt   1800
gttaatttgt taaaaaatag tacgtttaat aatcaaaact ttactctagc caatggtcaa   1860
aaacgcgttt cttttagttt tccgcctgaa ttggagaaaa aattaggtat caatatgcta   1920
gtaaaattaa taacaccaga tggaaaagta ttggagaaag tatctggtaa agtatttgga   1980
gaaggagtag ggaatattgc aaactttgaa ttagatcaac cttatttacc aggacaaaca   2040
tttaagtata ctatcgcttc aaaagattat ccagaagtaa gttatgatgg tacatttaca   2100
gttccaacct ctttagctta caaaatggcc agtcaaacga ttttctatcc tttccatgca   2160
ggggatactt atttaagagt gaaccctcaa tttgcagtgc ctaaaggaac tgatgcttta   2220
gtcagagtgt ttgatgaatt tcatggaaat gcttatttag aaaataacta taaagttggt   2280
gaaatcaaat taccgattcc gaaattaaac caaggaacaa ccagaacggc cggaaataaa   2340
attcctgtaa ccttcatggc aaatgcttat ttggacaatc aatcgactta tattgtggaa   2400
gtacctatct tggaaaaaga aaatcaaact gataaaccaa gtattctacc acaatttaaa   2460
aggaataaag cacaagaaaa cttaaaactt gatgaaaagg tagaagaacc aaagactagt   2520
gagaaggtag aaaaagaaaa actttctgaa actgggaata gtactagtaa ttcaacgtta   2580
gaagaagttc ctacagtgga tcctgtacaa gaaaaagtag caaaatttgc tgaaagttat   2640
gggatgaagc tagaaaatgt cttgtttaat atggacggaa caattgaatt atatttacca   2700
tcgggagaag tcattaaaaa gaatatggca gattttacag gagaagcacc tcaaggaaat   2760
ggtgaaaata aaccatctga aaatggaaaa gtatctactg gaacagttga gaaccaacca   2820
acagaaaata aaccagcaga ttctttacca gaggcaccaa acgaaaaacc tgtaaaacca   2880
gaaaactcaa cggataatgg aatgttgaat ccagaaggga atgtggggag tgaccctatg   2940
ttagatccag cattagagga agctccagca gtagatcctg tacaagaaaa attagaaaaa   3000
tttacagcta gttacggatt aggcttagat agtgttatat tcaatatgga tggaacgatt   3060
gaattaagat tgccaagtgg agaagtgata aaaaagaatt tatctgatct catagcg      3117

<210>   1988
<211>   1039
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (Pneumococcal histidine triad)
<223>   Cellular location: lipoprotein
<223>   Feature of note: similar to TeNT
<223>   Similar to strain R6 sequence 15902952 (0.E+01)

<400>   1988
Met Lys Phe Ser Lys Lys Tyr Ile Ala Ala Gly Ser Ala Val Ile Val 
1               5                   10                  15      

Ser Leu Ser Leu Cys Ala Tyr Ala Leu Asn Gln His Arg Ser Gln Glu 
            20                  25                  30          

Asn Lys Asp Asn Asn Arg Val Ser Tyr Val Asp Gly Ser Gln Ser Ser 
        35                  40                  45              

Gln Lys Ser Glu Asn Leu Thr Pro Asp Gln Val Ser Gln Lys Glu Gly 
    50                  55                  60                  

Ile Gln Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Leu Phe Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ala Asp Ile Val Asn Glu Val Lys Gly Gly Tyr Ile Ile 
        115                 120                 125             

Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Val Arg Thr Lys Asp Glu Ile Asn Arg Gln Lys Gln Glu His 
145                 150                 155                 160 

Val Lys Asp Asn Glu Lys Val Asn Ser Asn Val Ala Val Ala Arg Ser 
                165                 170                 175     

Gln Gly Arg Tyr Thr Thr Asn Asp Gly Tyr Val Phe Asn Pro Ala Asp 
            180                 185                 190         

Ile Ile Glu Asp Thr Gly Asn Ala Tyr Ile Val Pro His Gly Gly His 
        195                 200                 205             

Tyr His Tyr Ile Pro Lys Ser Asp Leu Ser Ala Ser Glu Leu Ala Ala 
    210                 215                 220                 

Ala Lys Ala His Leu Ala Gly Lys Asn Met Gln Pro Ser Gln Leu Ser 
225                 230                 235                 240 

Tyr Ser Ser Thr Ala Ser Asp Asn Asn Thr Gln Ser Val Ala Lys Gly 
                245                 250                 255     

Ser Thr Ser Lys Pro Ala Asn Lys Ser Glu Asn Leu Gln Ser Leu Leu 
            260                 265                 270         

Lys Glu Leu Tyr Asp Ser Pro Ser Ala Gln Arg Tyr Ser Glu Ser Asp 
        275                 280                 285             

Gly Leu Val Phe Asp Pro Ala Lys Ile Ile Ser Arg Thr Pro Asn Gly 
    290                 295                 300                 

Val Ala Ile Pro His Gly Asp His Tyr His Phe Ile Pro Tyr Ser Lys 
305                 310                 315                 320 

Leu Ser Ala Leu Glu Glu Lys Ile Ala Arg Met Val Pro Ile Ser Gly 
                325                 330                 335     

Thr Gly Ser Thr Val Ser Thr Asn Ala Lys Pro Asn Glu Val Val Ser 
            340                 345                 350         

Ser Leu Gly Ser Leu Ser Ser Asn Pro Ser Ser Leu Thr Thr Ser Lys 
        355                 360                 365             

Glu Leu Ser Ser Ala Ser Asp Gly Tyr Ile Phe Asn Pro Lys Asp Ile 
    370                 375                 380                 

Val Glu Glu Thr Ala Thr Ala Tyr Ile Val Arg His Gly Asp His Phe 
385                 390                 395                 400 

His Tyr Ile Pro Lys Ser Asn Gln Ile Gly Gln Pro Thr Leu Pro Asn 
                405                 410                 415     

Asn Ser Leu Ala Thr Pro Ser Pro Ser Leu Pro Ile Asn Pro Gly Thr 
            420                 425                 430         

Ser His Glu Lys His Glu Glu Asp Gly Tyr Gly Phe Asp Ala Asn Arg 
        435                 440                 445             

Ile Ile Ala Glu Asp Glu Ser Gly Phe Val Met Ser His Gly Asp His 
    450                 455                 460                 

Asn His Tyr Phe Phe Lys Lys Asp Leu Thr Glu Glu Gln Ile Lys Ala 
465                 470                 475                 480 

Ala Gln Lys His Leu Glu Glu Val Lys Thr Ser His Asn Gly Leu Asp 
                485                 490                 495     

Ser Leu Ser Ser His Glu Gln Asp Tyr Pro Ser Asn Ala Lys Glu Met 
            500                 505                 510         

Lys Asp Leu Asp Lys Lys Ile Glu Glu Lys Ile Ala Gly Ile Met Lys 
        515                 520                 525             

Gln Tyr Gly Val Lys Arg Glu Ser Ile Val Val Asn Lys Glu Lys Asn 
    530                 535                 540                 

Ala Ile Ile Tyr Pro His Gly Asp His His His Ala Asp Pro Ile Asp 
545                 550                 555                 560 

Glu His Lys Pro Val Gly Ile Gly His Ser His Ser Asn Tyr Glu Leu 
                565                 570                 575     

Phe Lys Pro Glu Glu Gly Val Ala Lys Lys Glu Gly Asn Lys Val Tyr 
            580                 585                 590         

Thr Gly Glu Glu Leu Thr Asn Val Val Asn Leu Leu Lys Asn Ser Thr 
        595                 600                 605             

Phe Asn Asn Gln Asn Phe Thr Leu Ala Asn Gly Gln Lys Arg Val Ser 
    610                 615                 620                 


Phe Ser Phe Pro Pro Glu Leu Glu Lys Lys Leu Gly Ile Asn Met Leu 
625                 630                 635                 640 

Val Lys Leu Ile Thr Pro Asp Gly Lys Val Leu Glu Lys Val Ser Gly 
                645                 650                 655     

Lys Val Phe Gly Glu Gly Val Gly Asn Ile Ala Asn Phe Glu Leu Asp 
            660                 665                 670         

Gln Pro Tyr Leu Pro Gly Gln Thr Phe Lys Tyr Thr Ile Ala Ser Lys 
        675                 680                 685             

Asp Tyr Pro Glu Val Ser Tyr Asp Gly Thr Phe Thr Val Pro Thr Ser 
    690                 695                 700                 

Leu Ala Tyr Lys Met Ala Ser Gln Thr Ile Phe Tyr Pro Phe His Ala 
705                 710                 715                 720 

Gly Asp Thr Tyr Leu Arg Val Asn Pro Gln Phe Ala Val Pro Lys Gly 
                725                 730                 735     

Thr Asp Ala Leu Val Arg Val Phe Asp Glu Phe His Gly Asn Ala Tyr 
            740                 745                 750         

Leu Glu Asn Asn Tyr Lys Val Gly Glu Ile Lys Leu Pro Ile Pro Lys 
        755                 760                 765             

Leu Asn Gln Gly Thr Thr Arg Thr Ala Gly Asn Lys Ile Pro Val Thr 
    770                 775                 780                 

Phe Met Ala Asn Ala Tyr Leu Asp Asn Gln Ser Thr Tyr Ile Val Glu 
785                 790                 795                 800 

Val Pro Ile Leu Glu Lys Glu Asn Gln Thr Asp Lys Pro Ser Ile Leu 
                805                 810                 815     

Pro Gln Phe Lys Arg Asn Lys Ala Gln Glu Asn Leu Lys Leu Asp Glu 
            820                 825                 830         

Lys Val Glu Glu Pro Lys Thr Ser Glu Lys Val Glu Lys Glu Lys Leu 
        835                 840                 845             

Ser Glu Thr Gly Asn Ser Thr Ser Asn Ser Thr Leu Glu Glu Val Pro 
    850                 855                 860                 

Thr Val Asp Pro Val Gln Glu Lys Val Ala Lys Phe Ala Glu Ser Tyr 
865                 870                 875                 880 

Gly Met Lys Leu Glu Asn Val Leu Phe Asn Met Asp Gly Thr Ile Glu 
                885                 890                 895     

Leu Tyr Leu Pro Ser Gly Glu Val Ile Lys Lys Asn Met Ala Asp Phe 
            900                 905                 910         

Thr Gly Glu Ala Pro Gln Gly Asn Gly Glu Asn Lys Pro Ser Glu Asn 
        915                 920                 925             

Gly Lys Val Ser Thr Gly Thr Val Glu Asn Gln Pro Thr Glu Asn Lys 
    930                 935                 940                 

Pro Ala Asp Ser Leu Pro Glu Ala Pro Asn Glu Lys Pro Val Lys Pro 
945                 950                 955                 960 


Glu Asn Ser Thr Asp Asn Gly Met Leu Asn Pro Glu Gly Asn Val Gly 
                965                 970                 975     

Ser Asp Pro Met Leu Asp Pro Ala Leu Glu Glu Ala Pro Ala Val Asp 
            980                 985                 990         

Pro Val Gln Glu Lys Leu Glu Lys Phe Thr Ala Ser Tyr Gly Leu Gly 
        995                 1000                1005            

Leu Asp Ser Val Ile Phe Asn Met Asp Gly Thr Ile Glu Leu Arg Leu 
    1010                1015                1020                

Pro Ser Gly Glu Val Ile Lys Lys Asn Leu Ser Asp Leu Ile Ala 
1025                1030                1035                

<210>   1989
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1989
ttgttagaaa ttactttaaa atccccttat caatttgctc atattctatt tcaatctact   60
atagtaccac atggtggtca ctatcatttc attcctgaga gtgacttgtc ggcaggtgaa   120
ttagcagcca catatgtctt taaccctaat gatattgtca gagatacagg tgatgcttat   180
atagtaagac atggggatca ctatcactat attcctaagt catctcttaa caatccccca   240
tcacactcta acacggaaga ggtaggaagt tcttctagtt ctgtattaag taatccgtca   300
ctacatgtcc atcatgagga agaagatggt catggttttg atgccaatcg aattataagt   360
gaagattcag aaggttttgt gattcctcat ggcgaccaca atcactacat caaggttcaa   420
actaagggat atgaagcggc tttgaaaaac aagattccat ccctgcaatc caactatcaa   480
cctggaactt ttgatgagaa ggcagtcttg gcaaaagtag atcaacttct agctgatagc   540
agaagcatct acaaagacag attgagt                                       567

<210>   1990
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   1990
Met Leu Glu Ile Thr Leu Lys Ser Pro Tyr Gln Phe Ala His Ile Leu 
1               5                   10                  15      

Phe Gln Ser Thr Ile Val Pro His Gly Gly His Tyr His Phe Ile Pro 
            20                  25                  30          

Glu Ser Asp Leu Ser Ala Gly Glu Leu Ala Ala Thr Tyr Val Phe Asn 
        35                  40                  45              

Pro Asn Asp Ile Val Arg Asp Thr Gly Asp Ala Tyr Ile Val Arg His 
    50                  55                  60                  

Gly Asp His Tyr His Tyr Ile Pro Lys Ser Ser Leu Asn Asn Pro Pro 
65                  70                  75                  80  

Ser His Ser Asn Thr Glu Glu Val Gly Ser Ser Ser Ser Ser Val Leu 
                85                  90                  95      

Ser Asn Pro Ser Leu His Val His His Glu Glu Glu Asp Gly His Gly 
            100                 105                 110         

Phe Asp Ala Asn Arg Ile Ile Ser Glu Asp Ser Glu Gly Phe Val Ile 
        115                 120                 125             

Pro His Gly Asp His Asn His Tyr Ile Lys Val Gln Thr Lys Gly Tyr 
    130                 135                 140                 


Glu Ala Ala Leu Lys Asn Lys Ile Pro Ser Leu Gln Ser Asn Tyr Gln 
145                 150                 155                 160 

Pro Gly Thr Phe Asp Glu Lys Ala Val Leu Ala Lys Val Asp Gln Leu 
                165                 170                 175     

Leu Ala Asp Ser Arg Ser Ile Tyr Lys Asp Arg Leu Ser 
            180                 185                 

<210>   1991
<211>   201
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1991
ttgatttgcc ttgctcaaaa gactttctac ttcttccttg ctatctgtcg cagattattg   60
gttgctatct accatgtact cctaaaacag gagagttata atccaagatt acaaggcctt   120
acagaaataa gaaatccaga taagacaatg ttcgtccaag acgctattcg cttcgcacag   180
cagcacggat tcaatatgct t                                             201

<210>   1992
<211>   67
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902955 (1.E-31)

<400>   1992
Met Ile Cys Leu Ala Gln Lys Thr Phe Tyr Phe Phe Leu Ala Ile Cys 
1               5                   10                  15      

Arg Arg Leu Leu Val Ala Ile Tyr His Val Leu Leu Lys Gln Glu Ser 
            20                  25                  30          

Tyr Asn Pro Arg Leu Gln Gly Leu Thr Glu Ile Arg Asn Pro Asp Lys 
        35                  40                  45              

Thr Met Phe Val Gln Asp Ala Ile Arg Phe Ala Gln Gln His Gly Phe 
    50                  55                  60                  

Asn Met Leu 
65          

<210>   1993
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1993
ttgagcaagg caaatcaact cttggaacaa atccatgaag aaggaatcag acaatccttg   60
gcagaagaag tagaaaatct aaaagctgcc acaaacaagg ctgatgcaga cttggatgaa   120
gtaaacagtc aggtaaaaga tgtcttgact cgtatcgcta gcgcccttca acaagaaaag   180
gaaaatgctg agcaagatcc tcagacactt gtactctatc aaaaactcta cgatattctc   240
atgtcgcttc actcttattt agaaagtaat aatggatctg atgcggactt tgataaggtg   300
gatgcattat tagatcaact ttctgctaag agtaaagaca aaacagcttt acttgaatcg   360
acaaaagcta ttctagtttt gaatcatcaa atccagtcaa aagctagcgc aagtgaagaa   420
acaagtccag caagaaatgc tgaagcaaat ggtgataaca ccagtgctga gaaccaacca   480
aacgcaactg cagaatctaa cattgaaact gctagcgacg aaaacaaacc aagcaataca   540
agagattcta aacctgctga atcaacttca gaaaatgaaa caacagaatc ttctacaact   600
actggaaatc aagaaaaacc agtagaa                                       627

<210>   1994
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902956 (e-112)

<400>   1994
Met Ser Lys Ala Asn Gln Leu Leu Glu Gln Ile His Glu Glu Gly Ile 
1               5                   10                  15      

Arg Gln Ser Leu Ala Glu Glu Val Glu Asn Leu Lys Ala Ala Thr Asn 
            20                  25                  30          

Lys Ala Asp Ala Asp Leu Asp Glu Val Asn Ser Gln Val Lys Asp Val 
        35                  40                  45              

Leu Thr Arg Ile Ala Ser Ala Leu Gln Gln Glu Lys Glu Asn Ala Glu 
    50                  55                  60                  

Gln Asp Pro Gln Thr Leu Val Leu Tyr Gln Lys Leu Tyr Asp Ile Leu 
65                  70                  75                  80  

Met Ser Leu His Ser Tyr Leu Glu Ser Asn Asn Gly Ser Asp Ala Asp 
                85                  90                  95      

Phe Asp Lys Val Asp Ala Leu Leu Asp Gln Leu Ser Ala Lys Ser Lys 
            100                 105                 110         

Asp Lys Thr Ala Leu Leu Glu Ser Thr Lys Ala Ile Leu Val Leu Asn 
        115                 120                 125             

His Gln Ile Gln Ser Lys Ala Ser Ala Ser Glu Glu Thr Ser Pro Ala 
    130                 135                 140                 

Arg Asn Ala Glu Ala Asn Gly Asp Asn Thr Ser Ala Glu Asn Gln Pro 
145                 150                 155                 160 

Asn Ala Thr Ala Glu Ser Asn Ile Glu Thr Ala Ser Asp Glu Asn Lys 
                165                 170                 175     

Pro Ser Asn Thr Arg Asp Ser Lys Pro Ala Glu Ser Thr Ser Glu Asn 
            180                 185                 190         

Glu Thr Thr Glu Ser Ser Thr Thr Thr Gly Asn Gln Glu Lys Pro Val 
        195                 200                 205             

Glu 
    

<210>   1995
<211>   1221
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1995
atgacttatc caaatctctt ggaccgcttc ttaacctatg ttaaggtcaa cacgcgctct   60
gatgaacact ctactactac tccaagtaca cagagtcagg ttgacttcgc aacaaatgtc   120
ctaattcctg aaatgaaacg tgttggactg caaaatgttt actatctacc gaatggtttt   180
gctattggaa ccttgccagc caacgatccg tctttaacac gtaagattgg ttttatatcg   240
cacatggata ctgctgattt taatgctgaa ggagtcaatc cacaggtaat tgaaaactac   300
gatggtggtg tgattgaact agggaattct ggtttcaaac tcgatccagc tgacttcaag   360
agtcttgaaa aatatccagg acaaacgctc atcacaacag atggaacaac cttgctaggt   420
gctgatgaca agtcaggaat tgctgaaatt atgacagcca ttgaatatct aactgctcat   480
cctgaaatta agcactgtga gattcgtgtt ggttttggtc cagatgaaga aatcggtgtt   540
ggtgccaata aatttgatgc agaagatttt gatgtggatt ttgcctacac tgttgatggt   600
ggtccactag gtgaacttca gtacgagact ttctcagccg ctggtgctga attgcatttc   660
caaggtcgta atgtccaccc tggtactgcc aaagggcaga tggtcaatgc ccttcagcta   720
gcaattgatt ttcataatca acttccagaa aatgaccgac ctgagttaac tgaaggttac   780
caaggttttt accatctaat ggatgtgaca ggtagtgttg aggaggcgcg tgcaagctac   840
atcattcgtg attttgaaaa agatgccttt gaagcgcgta aagcatccat gcaatctatc   900
gctgataaga tgaatgaaga acttgggagc gaccgtgtca ctctcaactt gacagaccag   960
tactacaata tgaaagaagt cattgaaaaa gatatgactc caattaccat tgctaaagcc   1020
gttatggaag atctaggtat cacgcctatt atcgaaccaa tccggggtgg aacagacggc   1080
tctaagattt cctttatggg aatcccaact ccgaatatct ttgcaggtgg cgaaaatatg   1140
cacggacgtt ttgaatacgt tagccttcag actatggaac gtgcagttga taccatcatt   1200
ggcatcgtag cttataaagg c                                             1221

<210>   1996
<211>   407
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidase t (pepT)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902957 (0.E+01)

<400>   1996
Met Thr Tyr Pro Asn Leu Leu Asp Arg Phe Leu Thr Tyr Val Lys Val 
1               5                   10                  15      

Asn Thr Arg Ser Asp Glu His Ser Thr Thr Thr Pro Ser Thr Gln Ser 
            20                  25                  30          

Gln Val Asp Phe Ala Thr Asn Val Leu Ile Pro Glu Met Lys Arg Val 
        35                  40                  45              

Gly Leu Gln Asn Val Tyr Tyr Leu Pro Asn Gly Phe Ala Ile Gly Thr 
    50                  55                  60                  

Leu Pro Ala Asn Asp Pro Ser Leu Thr Arg Lys Ile Gly Phe Ile Ser 
65                  70                  75                  80  

His Met Asp Thr Ala Asp Phe Asn Ala Glu Gly Val Asn Pro Gln Val 
                85                  90                  95      

Ile Glu Asn Tyr Asp Gly Gly Val Ile Glu Leu Gly Asn Ser Gly Phe 
            100                 105                 110         

Lys Leu Asp Pro Ala Asp Phe Lys Ser Leu Glu Lys Tyr Pro Gly Gln 
        115                 120                 125             

Thr Leu Ile Thr Thr Asp Gly Thr Thr Leu Leu Gly Ala Asp Asp Lys 
    130                 135                 140                 

Ser Gly Ile Ala Glu Ile Met Thr Ala Ile Glu Tyr Leu Thr Ala His 
145                 150                 155                 160 

Pro Glu Ile Lys His Cys Glu Ile Arg Val Gly Phe Gly Pro Asp Glu 
                165                 170                 175     

Glu Ile Gly Val Gly Ala Asn Lys Phe Asp Ala Glu Asp Phe Asp Val 
            180                 185                 190         

Asp Phe Ala Tyr Thr Val Asp Gly Gly Pro Leu Gly Glu Leu Gln Tyr 
        195                 200                 205             

Glu Thr Phe Ser Ala Ala Gly Ala Glu Leu His Phe Gln Gly Arg Asn 
    210                 215                 220                 

Val His Pro Gly Thr Ala Lys Gly Gln Met Val Asn Ala Leu Gln Leu 
225                 230                 235                 240 

Ala Ile Asp Phe His Asn Gln Leu Pro Glu Asn Asp Arg Pro Glu Leu 
                245                 250                 255     

Thr Glu Gly Tyr Gln Gly Phe Tyr His Leu Met Asp Val Thr Gly Ser 
            260                 265                 270         

Val Glu Glu Ala Arg Ala Ser Tyr Ile Ile Arg Asp Phe Glu Lys Asp 
        275                 280                 285             

Ala Phe Glu Ala Arg Lys Ala Ser Met Gln Ser Ile Ala Asp Lys Met 
    290                 295                 300                 

Asn Glu Glu Leu Gly Ser Asp Arg Val Thr Leu Asn Leu Thr Asp Gln 
305                 310                 315                 320 

Tyr Tyr Asn Met Lys Glu Val Ile Glu Lys Asp Met Thr Pro Ile Thr 
                325                 330                 335     

Ile Ala Lys Ala Val Met Glu Asp Leu Gly Ile Thr Pro Ile Ile Glu 
            340                 345                 350         

Pro Ile Arg Gly Gly Thr Asp Gly Ser Lys Ile Ser Phe Met Gly Ile 
        355                 360                 365             

Pro Thr Pro Asn Ile Phe Ala Gly Gly Glu Asn Met His Gly Arg Phe 
    370                 375                 380                 

Glu Tyr Val Ser Leu Gln Thr Met Glu Arg Ala Val Asp Thr Ile Ile 
385                 390                 395                 400 

Gly Ile Val Ala Tyr Lys Gly 
                405         

<210>   1997
<211>   1092
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1997
atgaaaaaag caattttaat gatgaccttc ggttcaccag aagagattat ctttgaaggt   60
gtagctgatt ttttcacaaa tattcgtcgt ggggtgagac cccaagacca cgagattcag   120
actctttatg ataattatgt acgaattgga ggcacgcctc tgcaaaaaat tacccgtcaa   180
gaggttgcct tggtagaagc taggctgggg agtgaataca gtgtctactt tgctaataag   240
ttttccagtc cctttattcc agatgtgatc ggtcaaatgg aagcagacgg aattgaacag   300
tgtatttgct tgattttgga gccccattat tctttctact ctgtcatggg ctatgaaaaa   360
tttttagaaa gcaaacaaat tcaatttttg gtcattaagg actggtatca ggaagaagcg   420
ctcttaaact attgggcaga tgaaattgct aagattttaa aagaagaagt aaagcaagac   480
agctttaaag tcatcttttc agcccatagt gtgcctattt ttgccttgga ctttggtgat   540
ccttatatag accaaatttt cgaaaatagc aagctagtcg ctgaaaaact gggcttgagt   600
tcagaacaat ataccaacac ttggcaaagt gagagtgata ttggtattcc atggattaaa   660
ccagatgttt tggagtatct cagagaacag acagaacatc cagaccatta tatttttgta   720
cctattagtt tcatcagtga gcatattgag gtcttgtttg acaatgatgt ggaatgttat   780
gacttatgtc aggaatttgg ggtaaactac catcgtccac caatgccaaa tacagattct   840
cgtttgattg atgctttggt caatacagtt agagtcaatg aaaatcaaga gtttaaggaa   900
tttctcccag aagaagagac ctttgatgag ttagttcctt cagacgagac gaaaaacatt   960
ttggctgaat ctcaagattt acaaatgcca gaatttgtga aaaaattgat tgagaaaaaa   1020
ggtcgtgaaa atgttaagat gccttatctt atcaaaaaaa tgcttgaaaa agcaggcaag   1080
ttacccaaag ag                                                       1092

<210>   1998
<211>   364
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ferrochelatase (hemH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902958 (0.E+01)

<400>   1998
Met Lys Lys Ala Ile Leu Met Met Thr Phe Gly Ser Pro Glu Glu Ile 
1               5                   10                  15      

Ile Phe Glu Gly Val Ala Asp Phe Phe Thr Asn Ile Arg Arg Gly Val 
            20                  25                  30          

Arg Pro Gln Asp His Glu Ile Gln Thr Leu Tyr Asp Asn Tyr Val Arg 
        35                  40                  45              

Ile Gly Gly Thr Pro Leu Gln Lys Ile Thr Arg Gln Glu Val Ala Leu 
    50                  55                  60                  

Val Glu Ala Arg Leu Gly Ser Glu Tyr Ser Val Tyr Phe Ala Asn Lys 
65                  70                  75                  80  

Phe Ser Ser Pro Phe Ile Pro Asp Val Ile Gly Gln Met Glu Ala Asp 
                85                  90                  95      

Gly Ile Glu Gln Cys Ile Cys Leu Ile Leu Glu Pro His Tyr Ser Phe 
            100                 105                 110         

Tyr Ser Val Met Gly Tyr Glu Lys Phe Leu Glu Ser Lys Gln Ile Gln 
        115                 120                 125             

Phe Leu Val Ile Lys Asp Trp Tyr Gln Glu Glu Ala Leu Leu Asn Tyr 
    130                 135                 140                 

Trp Ala Asp Glu Ile Ala Lys Ile Leu Lys Glu Glu Val Lys Gln Asp 
145                 150                 155                 160 

Ser Phe Lys Val Ile Phe Ser Ala His Ser Val Pro Ile Phe Ala Leu 
                165                 170                 175     

Asp Phe Gly Asp Pro Tyr Ile Asp Gln Ile Phe Glu Asn Ser Lys Leu 
            180                 185                 190         

Val Ala Glu Lys Leu Gly Leu Ser Ser Glu Gln Tyr Thr Asn Thr Trp 
        195                 200                 205             

Gln Ser Glu Ser Asp Ile Gly Ile Pro Trp Ile Lys Pro Asp Val Leu 
    210                 215                 220                 

Glu Tyr Leu Arg Glu Gln Thr Glu His Pro Asp His Tyr Ile Phe Val 
225                 230                 235                 240 

Pro Ile Ser Phe Ile Ser Glu His Ile Glu Val Leu Phe Asp Asn Asp 
                245                 250                 255     

Val Glu Cys Tyr Asp Leu Cys Gln Glu Phe Gly Val Asn Tyr His Arg 
            260                 265                 270         

Pro Pro Met Pro Asn Thr Asp Ser Arg Leu Ile Asp Ala Leu Val Asn 
        275                 280                 285             

Thr Val Arg Val Asn Glu Asn Gln Glu Phe Lys Glu Phe Leu Pro Glu 
    290                 295                 300                 

Glu Glu Thr Phe Asp Glu Leu Val Pro Ser Asp Glu Thr Lys Asn Ile 
305                 310                 315                 320 

Leu Ala Glu Ser Gln Asp Leu Gln Met Pro Glu Phe Val Lys Lys Leu 
                325                 330                 335     

Ile Glu Lys Lys Gly Arg Glu Asn Val Lys Met Pro Tyr Leu Ile Lys 
            340                 345                 350         

Lys Met Leu Glu Lys Ala Gly Lys Leu Pro Lys Glu 
        355                 360                 

<210>   1999
<211>   375
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   1999
atgttaaaaa atctaaaatc gttcttgctt cgaggaaatg ttattgacct tgctgtcggt   60
gttgtaattg cctctgcttt tggtgctatc gttacttcac ttgtaaacga cattatcact   120
cctcttattt taaatcccgc tttgaaagct gctaaagttg aacgtatcgc tcaactttct   180
tggcatggag tcggctatgg taacttctta agtgctatta tcaattttat ctttgtgggt   240
accgccctct tctttattat caagggcatt gaaaaagcac agaagctgac tggcataaag   300
gaagaaaaaa ctgacgaaaa aaaaccaacc gaattggaag tccttcaaga aataaaagct   360
ctccttgaga aaaaa                                                    375

<210>   2000
<211>   125
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   large conductance mechanosensitive channel protein MscL (mscL)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902959 (1.E-63)

<400>   2000
Met Leu Lys Asn Leu Lys Ser Phe Leu Leu Arg Gly Asn Val Ile Asp 
1               5                   10                  15      

Leu Ala Val Gly Val Val Ile Ala Ser Ala Phe Gly Ala Ile Val Thr 
            20                  25                  30          

Ser Leu Val Asn Asp Ile Ile Thr Pro Leu Ile Leu Asn Pro Ala Leu 
        35                  40                  45              

Lys Ala Ala Lys Val Glu Arg Ile Ala Gln Leu Ser Trp His Gly Val 
    50                  55                  60                  

Gly Tyr Gly Asn Phe Leu Ser Ala Ile Ile Asn Phe Ile Phe Val Gly 
65                  70                  75                  80  

Thr Ala Leu Phe Phe Ile Ile Lys Gly Ile Glu Lys Ala Gln Lys Leu 
                85                  90                  95      

Thr Gly Ile Lys Glu Glu Lys Thr Asp Glu Lys Lys Pro Thr Glu Leu 
            100                 105                 110         

Glu Val Leu Gln Glu Ile Lys Ala Leu Leu Glu Lys Lys 
        115                 120                 125 

<210>   2001
<211>   429
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2001
atgaaaaaac ctattcaaaa attttttaac aatgaaatct tagcctatct cttttttggt   60
atagtgacta ctcttgttgc tatactatca cgattagtca tttatcagct aagtcatcag   120
gaactccttg ctacggcctt ggcaaatatt atcggtatcc tatttgcctt tatcacaaat   180
gatacgattg tatttaagca aaaaaagaaa aatagactta tccgtttagt gaaattttct   240
cttgcccgcc tttctacttt tctgttagac ttgtttttaa cttttctctt tgtaacccaa   300
tttcctcaca tcatagggca attcgtaact gaaaacattg ataagataaa tgctattgaa   360
acaataattg cacaaatatt cattattatc atcaattata tcttgagcaa ggtctatatt   420
tttagaaaa                                                           429

<210>   2002
<211>   143
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GtrA family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902960 (5.E-74)

<400>   2002
Met Lys Lys Pro Ile Gln Lys Phe Phe Asn Asn Glu Ile Leu Ala Tyr 
1               5                   10                  15      

Leu Phe Phe Gly Ile Val Thr Thr Leu Val Ala Ile Leu Ser Arg Leu 
            20                  25                  30          

Val Ile Tyr Gln Leu Ser His Gln Glu Leu Leu Ala Thr Ala Leu Ala 
        35                  40                  45              

Asn Ile Ile Gly Ile Leu Phe Ala Phe Ile Thr Asn Asp Thr Ile Val 
    50                  55                  60                  

Phe Lys Gln Lys Lys Lys Asn Arg Leu Ile Arg Leu Val Lys Phe Ser 
65                  70                  75                  80  

Leu Ala Arg Leu Ser Thr Phe Leu Leu Asp Leu Phe Leu Thr Phe Leu 
                85                  90                  95      

Phe Val Thr Gln Phe Pro His Ile Ile Gly Gln Phe Val Thr Glu Asn 
            100                 105                 110         

Ile Asp Lys Ile Asn Ala Ile Glu Thr Ile Ile Ala Gln Ile Phe Ile 
        115                 120                 125             

Ile Ile Ile Asn Tyr Ile Leu Ser Lys Val Tyr Ile Phe Arg Lys 
    130                 135                 140             

<210>   2003
<211>   507
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2003
atgaaaaaat taactattcg tgatgttgca gatattgcaa tcgtcgctgc tatctacgtc   60
gttttgactg tcacaccgcc cctaaatgcc atcagctatg gtgcttatca gtttcgtatt   120
tcagaaatga tgaactttat ggctttttac aatcctaagt acatcatcgg agttaccatc   180
ggttgtatga ttgctaattt ctttagcttc ggactgctag atgtctttgt tggtggtggt   240
tcaaccttag tattcctcag tttaggtgtt tggctttttg caaaatatag caaggattac   300
ctctttaacg gattgattcg aaaagatcat ttcttctttt caatcctctt ttcaatttcc   360
atgtttacta tcgctgcaga gttaaatatt gtagcagaat taccattctt ccttacttgg   420
tttacaacag gaatcggtga atttgcttca ttgattattg gagcgattat tattggtaaa   480
attggtcgtc gaattgattt aagtaaa                                       507

<210>   2004
<211>   169
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902961 (2.E-93)

<400>   2004
Met Lys Lys Leu Thr Ile Arg Asp Val Ala Asp Ile Ala Ile Val Ala 
1               5                   10                  15      

Ala Ile Tyr Val Val Leu Thr Val Thr Pro Pro Leu Asn Ala Ile Ser 
            20                  25                  30          

Tyr Gly Ala Tyr Gln Phe Arg Ile Ser Glu Met Met Asn Phe Met Ala 
        35                  40                  45              

Phe Tyr Asn Pro Lys Tyr Ile Ile Gly Val Thr Ile Gly Cys Met Ile 
    50                  55                  60                  

Ala Asn Phe Phe Ser Phe Gly Leu Leu Asp Val Phe Val Gly Gly Gly 
65                  70                  75                  80  

Ser Thr Leu Val Phe Leu Ser Leu Gly Val Trp Leu Phe Ala Lys Tyr 
                85                  90                  95      

Ser Lys Asp Tyr Leu Phe Asn Gly Leu Ile Arg Lys Asp His Phe Phe 
            100                 105                 110         


Phe Ser Ile Leu Phe Ser Ile Ser Met Phe Thr Ile Ala Ala Glu Leu 
        115                 120                 125             

Asn Ile Val Ala Glu Leu Pro Phe Phe Leu Thr Trp Phe Thr Thr Gly 
    130                 135                 140                 

Ile Gly Glu Phe Ala Ser Leu Ile Ile Gly Ala Ile Ile Ile Gly Lys 
145                 150                 155                 160 

Ile Gly Arg Arg Ile Asp Leu Ser Lys 
                165                 

<210>   2005
<211>   1074
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2005
atgggatata cagttgctgt agtcggcgcg acaggtgctg tcggtgctca gatgataaaa   60
atgttggaag aatcaacact tccaatcgat aaaattcgtt accttgcttc tgcacgttca   120
gcaggtaagt cattgaaatt taaagatcaa gatattacaa ttgaagaaac gactgaaaca   180
gcttttgaag gagttgatat tgctctcttt tcagcaggta gttctacatc agctaagtat   240
gcaccatacg cagtaaaagc tggcgtggta gtagtagata atacatctta tttccgtcaa   300
aatccagatg ttcctttggt tgttccagag gtcaatgctc atgcacttga tgctcacaac   360
ggaatcattg cctgccctaa ttgttcaaca attcaaatga tggtggctct tgagccggtt   420
cgccaaaaat ggggcttgga ccgtatcatt gtttcaactt atcaagccgt ttcaggtgct   480
ggtatgggag caattcttga gacacaacgt gaacttcgtg aagtcttgaa tgatggtgtg   540
aaaccacgtg atttgcatgc ggaaatcttg ccttcaggtg gtgacaagaa acattatcct   600
atcgccttta acgctcttcc acaaattgat gttttcactg ataatgatta cacgtacgaa   660
gagatgaaga tgaccaagga aactaagaaa attatggaag atgatagcat tgcagtatct   720
gcaacatgtg tgcgtattcc agtcttgtca gctcactctg agtctgttta tatcgaaaca   780
aaagaagtgg ctccaatcga agaagtaaaa gcagctatcg cagccttccc aggtgctgtt   840
cttgaagatg atgtagctca tcaaatctat cctcaagcta tcaatgcagt tggttcgcgt   900
gatacctttg ttggtcgtat ccgtaaagac ttggatgcag aaaaaggaat tcacatgtgg   960
gttgtttcag ataaccttct caaaggtgct gcttggaact cagttcagat tgctgaaact   1020
cttcatgaac gtggattggt tcgtccaaca gccgaattga aatttgaatt aaaa         1074

<210>   2006
<211>   358
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aspartate-semialdehyde dehydrogenase (asd)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902962 (0.E+01)

<400>   2006
Met Gly Tyr Thr Val Ala Val Val Gly Ala Thr Gly Ala Val Gly Ala 
1               5                   10                  15      

Gln Met Ile Lys Met Leu Glu Glu Ser Thr Leu Pro Ile Asp Lys Ile 
            20                  25                  30          

Arg Tyr Leu Ala Ser Ala Arg Ser Ala Gly Lys Ser Leu Lys Phe Lys 
        35                  40                  45              

Asp Gln Asp Ile Thr Ile Glu Glu Thr Thr Glu Thr Ala Phe Glu Gly 
    50                  55                  60                  

Val Asp Ile Ala Leu Phe Ser Ala Gly Ser Ser Thr Ser Ala Lys Tyr 
65                  70                  75                  80  

Ala Pro Tyr Ala Val Lys Ala Gly Val Val Val Val Asp Asn Thr Ser 
                85                  90                  95      

Tyr Phe Arg Gln Asn Pro Asp Val Pro Leu Val Val Pro Glu Val Asn 
            100                 105                 110         

Ala His Ala Leu Asp Ala His Asn Gly Ile Ile Ala Cys Pro Asn Cys 
        115                 120                 125             

Ser Thr Ile Gln Met Met Val Ala Leu Glu Pro Val Arg Gln Lys Trp 
    130                 135                 140                 

Gly Leu Asp Arg Ile Ile Val Ser Thr Tyr Gln Ala Val Ser Gly Ala 
145                 150                 155                 160 

Gly Met Gly Ala Ile Leu Glu Thr Gln Arg Glu Leu Arg Glu Val Leu 
                165                 170                 175     

Asn Asp Gly Val Lys Pro Arg Asp Leu His Ala Glu Ile Leu Pro Ser 
            180                 185                 190         

Gly Gly Asp Lys Lys His Tyr Pro Ile Ala Phe Asn Ala Leu Pro Gln 
        195                 200                 205             

Ile Asp Val Phe Thr Asp Asn Asp Tyr Thr Tyr Glu Glu Met Lys Met 
    210                 215                 220                 

Thr Lys Glu Thr Lys Lys Ile Met Glu Asp Asp Ser Ile Ala Val Ser 
225                 230                 235                 240 

Ala Thr Cys Val Arg Ile Pro Val Leu Ser Ala His Ser Glu Ser Val 
                245                 250                 255     

Tyr Ile Glu Thr Lys Glu Val Ala Pro Ile Glu Glu Val Lys Ala Ala 
            260                 265                 270         

Ile Ala Ala Phe Pro Gly Ala Val Leu Glu Asp Asp Val Ala His Gln 
        275                 280                 285             

Ile Tyr Pro Gln Ala Ile Asn Ala Val Gly Ser Arg Asp Thr Phe Val 
    290                 295                 300                 

Gly Arg Ile Arg Lys Asp Leu Asp Ala Glu Lys Gly Ile His Met Trp 
305                 310                 315                 320 

Val Val Ser Asp Asn Leu Leu Lys Gly Ala Ala Trp Asn Ser Val Gln 
                325                 330                 335     

Ile Ala Glu Thr Leu His Glu Arg Gly Leu Val Arg Pro Thr Ala Glu 
            340                 345                 350         

Leu Lys Phe Glu Leu Lys 
        355             

<210>   2007
<211>   933
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2007
gtgtcttatc aagatttaaa aaaatgtaaa atcattacag cctttattac ccccttccat   60
gaggatggtt ccattaactt tgatgctatt ccagccttga ttgagcattt attggcccat   120
catacggatg gaattcttct cgcaggaacg actgctgaga gtccaacttt gacccacgat   180
gaggagttgg agttgtttgc ggctgtacaa aaggttgtca atggacgcgt tcctttgatt   240
gcgggtgtag gtactaatga tacgcgtgac tctattgagt ttgtcaaaga agtagcggaa   300
tttggtggtt tcgcagctgg gcttgctatt gttccttact acaacaaacc ttctcaagaa   360
gggatgtatc agcactttaa gactattgca gatgcttctg acctaccaat tattatctat   420
aacattccag ggcgtgtagt tgtcgaattg actccagaaa ccatgcttcg cttggctgac   480
catccaaata ttatcggtgt caaagaatgt actagcttgg ctaatatggc ttacttgatt   540
gagcacaagc ctgaagagtt cttgatttat acaggtgagg atggagatgc tttccatgcc   600
atgaaccttg gggcggatgg ggttatttct gttgcctctc atacaaatgg ggatgaaatg   660
cacgagatgt ttactgcgat tgcagaaagc gatatgaaga aagccgcagc aattcagcgt   720
aaattcattc ctaaggttaa tgctctcttc tcttatccaa gtcctgctcc agttaaggca   780
attcttaact atatgggatt tgaagctgga cccactcgtc tacctcttgt tccagcacca   840
gaagaagatg ccaaacgcat tatcaaggtt gtcgtagatg gcgactacga agcaactaag   900
gcaactgtaa caggggtctt aagaccagat tac                                933

<210>   2008
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydrodipicolinate synthase (dapA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902963 (e-176)

<400>   2008
Met Ser Tyr Gln Asp Leu Lys Lys Cys Lys Ile Ile Thr Ala Phe Ile 
1               5                   10                  15      

Thr Pro Phe His Glu Asp Gly Ser Ile Asn Phe Asp Ala Ile Pro Ala 
            20                  25                  30          

Leu Ile Glu His Leu Leu Ala His His Thr Asp Gly Ile Leu Leu Ala 
        35                  40                  45              

Gly Thr Thr Ala Glu Ser Pro Thr Leu Thr His Asp Glu Glu Leu Glu 
    50                  55                  60                  

Leu Phe Ala Ala Val Gln Lys Val Val Asn Gly Arg Val Pro Leu Ile 
65                  70                  75                  80  

Ala Gly Val Gly Thr Asn Asp Thr Arg Asp Ser Ile Glu Phe Val Lys 
                85                  90                  95      

Glu Val Ala Glu Phe Gly Gly Phe Ala Ala Gly Leu Ala Ile Val Pro 
            100                 105                 110         

Tyr Tyr Asn Lys Pro Ser Gln Glu Gly Met Tyr Gln His Phe Lys Thr 
        115                 120                 125             

Ile Ala Asp Ala Ser Asp Leu Pro Ile Ile Ile Tyr Asn Ile Pro Gly 
    130                 135                 140                 

Arg Val Val Val Glu Leu Thr Pro Glu Thr Met Leu Arg Leu Ala Asp 
145                 150                 155                 160 

His Pro Asn Ile Ile Gly Val Lys Glu Cys Thr Ser Leu Ala Asn Met 
                165                 170                 175     

Ala Tyr Leu Ile Glu His Lys Pro Glu Glu Phe Leu Ile Tyr Thr Gly 
            180                 185                 190         

Glu Asp Gly Asp Ala Phe His Ala Met Asn Leu Gly Ala Asp Gly Val 
        195                 200                 205             

Ile Ser Val Ala Ser His Thr Asn Gly Asp Glu Met His Glu Met Phe 
    210                 215                 220                 

Thr Ala Ile Ala Glu Ser Asp Met Lys Lys Ala Ala Ala Ile Gln Arg 
225                 230                 235                 240 

Lys Phe Ile Pro Lys Val Asn Ala Leu Phe Ser Tyr Pro Ser Pro Ala 
                245                 250                 255     

Pro Val Lys Ala Ile Leu Asn Tyr Met Gly Phe Glu Ala Gly Pro Thr 
            260                 265                 270         

Arg Leu Pro Leu Val Pro Ala Pro Glu Glu Asp Ala Lys Arg Ile Ile 
        275                 280                 285             

Lys Val Val Val Asp Gly Asp Tyr Glu Ala Thr Lys Ala Thr Val Thr 
    290                 295                 300                 

Gly Val Leu Arg Pro Asp Tyr 
305                 310     

<210>   2009
<211>   1098
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2009
atgactttca aaaaaccttc taaaattcct tatcttgaaa cgactggtat gcccactaga   60
attctcctta gaaagcgtcg attcaagtgc tatcactgtt caaaaatgat ggtcgctgaa   120
acttctatcg tcaagaagaa tcaccaaatc cctcgtatca tcaaccaaaa gattgctcaa   180
aagttaattg aaaagatttc tatgactgat attgcccatc agctttccat ctcaacttca   240
actgttattc gtaagctcaa tgactttcac tttaaacatg atttttcttg tcttcctgag   300
attatgtctt gggatgagta tgcttttaca aaaggaaaga tgagcttcat tgcgcaagat   360
tttaacaatc tcaatatcat cactgttctt aagggaagaa cacaagctgt catccgaaat   420
cactttctta aatatgatag agccgtccga tgtcgcgtca aaatcattac tatggatatg   480

tttagtcctt actatgactt agctagacaa cttttcccgt gtgctaaaat cgtgttggat   540
cgctttcaca ttgtacaaca tcttagccgt gctatgagtc gtgtgcgtgt ccaaatcatg   600
aatcagtttc atcgaaaatc ccatgaatac aaggctatca agcgctactg gaaactcatt   660
caacaggata gccgtaaact gagtgataag cgattttatc gtcctacttt tcgtatgcac   720
ttaaccaata aagagatttt aaacaagctt ttgagctatt cacaaaactt gaaacatcac   780
tatcagctct atcaactctt gctgtttcac tttcagaata aggaaccgga gaaatttttc   840
ggactcattg aggacaatct gaagcaggtt catcctattt ttcagactgt ctttaaaacc   900
tttctaaagg acaaaaagaa aatcgtcaac acccttcaac taccctattc aaacgccaaa   960
ttggaagcga ccaataatct catcaaactt atcaagcgca atgcctttgg ttttcggaac   1020
tttgaaaact tcaaaaaacg gatttttatc gctctgaata tcaaaaaaga aaggacaaaa   1080
tttgtccttt ctcgagct                                                 1098

<210>   2010
<211>   366
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   2010
Met Thr Phe Lys Lys Pro Ser Lys Ile Pro Tyr Leu Glu Thr Thr Gly 
1               5                   10                  15      

Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe Lys Cys Tyr His 
            20                  25                  30          

Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val Lys Lys Asn His 
        35                  40                  45              

Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln Lys Leu Ile Glu 
    50                  55                  60                  

Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ser Ile Ser Thr Ser 
65                  70                  75                  80  

Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Lys His Asp Phe Ser 
                85                  90                  95      

Cys Leu Pro Glu Ile Met Ser Trp Asp Glu Tyr Ala Phe Thr Lys Gly 
            100                 105                 110         

Lys Met Ser Phe Ile Ala Gln Asp Phe Asn Asn Leu Asn Ile Ile Thr 
        115                 120                 125             

Val Leu Lys Gly Arg Thr Gln Ala Val Ile Arg Asn His Phe Leu Lys 
    130                 135                 140                 

Tyr Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile Thr Met Asp Met 
145                 150                 155                 160 

Phe Ser Pro Tyr Tyr Asp Leu Ala Arg Gln Leu Phe Pro Cys Ala Lys 
                165                 170                 175     

Ile Val Leu Asp Arg Phe His Ile Val Gln His Leu Ser Arg Ala Met 
            180                 185                 190         

Ser Arg Val Arg Val Gln Ile Met Asn Gln Phe His Arg Lys Ser His 
        195                 200                 205             

Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile Gln Gln Asp Ser 
    210                 215                 220                 

Arg Lys Leu Ser Asp Lys Arg Phe Tyr Arg Pro Thr Phe Arg Met His 
225                 230                 235                 240 

Leu Thr Asn Lys Glu Ile Leu Asn Lys Leu Leu Ser Tyr Ser Gln Asn 
                245                 250                 255     


Leu Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu Phe His Phe Gln 
            260                 265                 270         

Asn Lys Glu Pro Glu Lys Phe Phe Gly Leu Ile Glu Asp Asn Leu Lys 
        275                 280                 285             

Gln Val His Pro Ile Phe Gln Thr Val Phe Lys Thr Phe Leu Lys Asp 
    290                 295                 300                 

Lys Lys Lys Ile Val Asn Thr Leu Gln Leu Pro Tyr Ser Asn Ala Lys 
305                 310                 315                 320 

Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys Arg Asn Ala Phe 
                325                 330                 335     

Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile Phe Ile Ala Leu 
            340                 345                 350         

Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser Arg Ala 
        355                 360                 365     

<210>   2011
<211>   1255
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2011
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa aaccttctaa   180
aattccttat cttgaaacga ctggtatgcc cactagaatt ctccttagaa agcgtcgatt   240
caagtgctat cactgttcaa aaatgatggt cgctgaaact tctatcgtca agaagaatca   300
ccaaatccct cgtatcatca accaaaagat tgctcaaaag ttaattgaaa agatttctat   360
gactgatatt gcccatcagc tttccatctc aacttcaact gttattcgta agctcaatga   420
ctttcacttt aaacatgatt tttcttgtct tcctgagatt atgtcttggg atgagtatgc   480
ttttacaaaa ggaaagatga gcttcattgc gcaagatttt aacaatctca atatcatcac   540
tgttcttaag ggaagaacac aagctgtcat ccgaaatcac tttcttaaat atgatagagc   600
cgtccgatgt cgcgtcaaaa tcattactat ggatatgttt agtccttact atgacttagc   660
tagacaactt ttcccgtgtg ctaaaatcgt gttggatcgc tttcacattg tacaacatct   720
tagccgtgct atgagtcgtg tgcgtgtcca aatcatgaat cagtttcatc gaaaatccca   780
tgaatacaag gctatcaagc gctactggaa actcattcaa caggatagcc gtaaactgag   840
tgataagcga ttttatcgtc ctacttttcg tatgcactta accaataaag agattttaaa   900
caagcttttg agctattcac aaaacttgaa acatcactat cagctctatc aactcttgct   960
gtttcacttt cagaataagg aaccggagaa atttttcgga ctcattgagg acaatctgaa   1020
gcaggttcat cctatttttc agactgtctt taaaaccttt ctaaaggaca aaaagaaaat   1080
cgtcaacacc cttcaactac cctattcaaa cgccaaattg gaagcgacca ataatctcat   1140
caaacttatc aagcgcaatg cctttggttt tcggaacttt gaaaacttca aaaaacggat   1200
ttttatcgct ctgaatatca aaaaagaaag gacaaaattt gtcctttctc gagct        1255

<210>   2012
<211>   59
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase FRAMESHIFT

<400>   2012
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Thr Phe 
    50                  55                  

<210>   2013
<211>   1437
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2013
ttgttacaat ttgaaaagaa acttggagaa tttccaagaa aagagctatt aattaaagga   60
aacattatga ttacacgtga atttgatacc atcgctgcta tctctactcc actaggtgaa   120
ggggctattg gtattgtccg cctgagcgga acagacagtt ttgctattgc gcaaaagatt   180
tttaaaggaa aagacttgaa caaggttgcc agccacactc tcaactacgg tcacattatt   240
gatcctctga ctggtaaagt catggacgag gttatggttg gggctatgaa gtctccaaag   300
accttcactc gtgaggatat tatcgagatt aacacccacg gtgggattgc ggtgaccaat   360
gaaattctcc agctagctat tcgtgaaggg gctcggttgg cagaacctgg tgaatttacc   420
aaacgtgctt ttttaaacgg tcgcgtagac ttgacacagg cagaggctgt gatggatatc   480
atccgtgcca agactgacaa ggccatgaac attgcggtca aacaattaga cggctccctt   540
tctgacctca ttaacaatac ccgtcaagaa atcctcaata cacttgccca agttgaggtc   600
aatatcgact atcctgagta tgacgatgtt gaggaagcca ctactgctgt tgtccgagag   660
aagacaatgg agtttgagca attactaacc aaactcctta ggacagcacg tcgtggtaaa   720
atccttcgtg aaggaatttc aacggctatc attggacgtc ccaacgttgg gaaatcaagc   780
cttctcaaca acctcttgcg tgaggacaag gctatcgtaa cagatatcgc tgggacaaca   840
cgagatgtca tcgaagagta cgtcaacatc aatggtgtac ctctcaaatt gattgataca   900
gccggtattc gtgaaacgga tgatatcgtt gaacaaattg gagttgagcg ttcgaaaaaa   960
gctcttaagg aagctgacct agttctgcta gtactaaacg ctagtgaacc actaaccgcc   1020
caagatcgcc aactcctaga aatcagtcag gagactaatc gcattattct tcttaacaaa   1080
actgacctgc ctgaaacgat tgaaacttcg gaactacctg aagatgtcat ccgcatttca   1140
gttcttaaaa atcaaaacat cgataaaatc gaagagagaa tcaacaacct cttctttgaa   1200
aatgctggtt tggttgagca agatgctacc tacttgtcaa acgcccgtca catttccttg   1260
attgagaagg ccgttgaaag cctacaagct gttaaccaag gtcttgaact agggatgcca   1320
gttgacttgc ttcaagttga cttgacccgt acttgggaaa ttctaggaga aatcactgga   1380
gatgctgctc cagatgaact catcacccaa ctctttagcc aattctgttt aggaaaa      1437

<210>   2014
<211>   479
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thiophene and furan oxidation protein ThdF (thdF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902964 (0.E+01)

<400>   2014
Met Leu Gln Phe Glu Lys Lys Leu Gly Glu Phe Pro Arg Lys Glu Leu 
1               5                   10                  15      

Leu Ile Lys Gly Asn Ile Met Ile Thr Arg Glu Phe Asp Thr Ile Ala 
            20                  25                  30          

Ala Ile Ser Thr Pro Leu Gly Glu Gly Ala Ile Gly Ile Val Arg Leu 
        35                  40                  45              

Ser Gly Thr Asp Ser Phe Ala Ile Ala Gln Lys Ile Phe Lys Gly Lys 
    50                  55                  60                  

Asp Leu Asn Lys Val Ala Ser His Thr Leu Asn Tyr Gly His Ile Ile 
65                  70                  75                  80  

Asp Pro Leu Thr Gly Lys Val Met Asp Glu Val Met Val Gly Ala Met 
                85                  90                  95      

Lys Ser Pro Lys Thr Phe Thr Arg Glu Asp Ile Ile Glu Ile Asn Thr 
            100                 105                 110         

His Gly Gly Ile Ala Val Thr Asn Glu Ile Leu Gln Leu Ala Ile Arg 
        115                 120                 125             

Glu Gly Ala Arg Leu Ala Glu Pro Gly Glu Phe Thr Lys Arg Ala Phe 
    130                 135                 140                 


Leu Asn Gly Arg Val Asp Leu Thr Gln Ala Glu Ala Val Met Asp Ile 
145                 150                 155                 160 

Ile Arg Ala Lys Thr Asp Lys Ala Met Asn Ile Ala Val Lys Gln Leu 
                165                 170                 175     

Asp Gly Ser Leu Ser Asp Leu Ile Asn Asn Thr Arg Gln Glu Ile Leu 
            180                 185                 190         

Asn Thr Leu Ala Gln Val Glu Val Asn Ile Asp Tyr Pro Glu Tyr Asp 
        195                 200                 205             

Asp Val Glu Glu Ala Thr Thr Ala Val Val Arg Glu Lys Thr Met Glu 
    210                 215                 220                 

Phe Glu Gln Leu Leu Thr Lys Leu Leu Arg Thr Ala Arg Arg Gly Lys 
225                 230                 235                 240 

Ile Leu Arg Glu Gly Ile Ser Thr Ala Ile Ile Gly Arg Pro Asn Val 
                245                 250                 255     

Gly Lys Ser Ser Leu Leu Asn Asn Leu Leu Arg Glu Asp Lys Ala Ile 
            260                 265                 270         

Val Thr Asp Ile Ala Gly Thr Thr Arg Asp Val Ile Glu Glu Tyr Val 
        275                 280                 285             

Asn Ile Asn Gly Val Pro Leu Lys Leu Ile Asp Thr Ala Gly Ile Arg 
    290                 295                 300                 

Glu Thr Asp Asp Ile Val Glu Gln Ile Gly Val Glu Arg Ser Lys Lys 
305                 310                 315                 320 

Ala Leu Lys Glu Ala Asp Leu Val Leu Leu Val Leu Asn Ala Ser Glu 
                325                 330                 335     

Pro Leu Thr Ala Gln Asp Arg Gln Leu Leu Glu Ile Ser Gln Glu Thr 
            340                 345                 350         

Asn Arg Ile Ile Leu Leu Asn Lys Thr Asp Leu Pro Glu Thr Ile Glu 
        355                 360                 365             

Thr Ser Glu Leu Pro Glu Asp Val Ile Arg Ile Ser Val Leu Lys Asn 
    370                 375                 380                 

Gln Asn Ile Asp Lys Ile Glu Glu Arg Ile Asn Asn Leu Phe Phe Glu 
385                 390                 395                 400 

Asn Ala Gly Leu Val Glu Gln Asp Ala Thr Tyr Leu Ser Asn Ala Arg 
                405                 410                 415     

His Ile Ser Leu Ile Glu Lys Ala Val Glu Ser Leu Gln Ala Val Asn 
            420                 425                 430         

Gln Gly Leu Glu Leu Gly Met Pro Val Asp Leu Leu Gln Val Asp Leu 
        435                 440                 445             

Thr Arg Thr Trp Glu Ile Leu Gly Glu Ile Thr Gly Asp Ala Ala Pro 
    450                 455                 460                 

Asp Glu Leu Ile Thr Gln Leu Phe Ser Gln Phe Cys Leu Gly Lys 
465                 470                 475                 

<210>   2015
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2015
gtggaggaag ctattatgcc atttgtacgc atcgatttat ttgaaggacg cacgctcgag   60
caaaagaaag ctcttgctaa ggaagtaacg gaagcagttg tccgcaacac tggagcccct   120
caatctgctg tccatgtcat catcaacgac atgccagaag gaacttactt cccacaaggg   180
gaaatgcgta ctaaa                                                    195

<210>   2016
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   4-oxalocrotonate tautomerase (xylH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902965 (2.E-30)

<400>   2016
Met Glu Glu Ala Ile Met Pro Phe Val Arg Ile Asp Leu Phe Glu Gly 
1               5                   10                  15      

Arg Thr Leu Glu Gln Lys Lys Ala Leu Ala Lys Glu Val Thr Glu Ala 
            20                  25                  30          

Val Val Arg Asn Thr Gly Ala Pro Gln Ser Ala Val His Val Ile Ile 
        35                  40                  45              

Asn Asp Met Pro Glu Gly Thr Tyr Phe Pro Gln Gly Glu Met Arg Thr 
    50                  55                  60                  

Lys 
65  

<210>   2017
<211>   597
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2017
atggcacagt tgtactatcg ttatgggacc atgaactctg gtaaaacgat tgagattctc   60
aaagtggcct ataactacga ggagcaagga aaaggtgttg tgattatgac ctcggctctg   120
gatacgcgtg acggcgttgg ctatgtgtcg agtcgaattg gcatgaaacg ccctgccctt   180
gcgattgagg aaacaacgga tatctttggc tatatccgag acctaccaga aaaaccttac   240
tgtgttttgg tcgatgaagc ccagtttctc aaacgccacc atgtttacga cctagctcgt   300
gttgtggacg agttagacat acccgtcatg gcttttggct tgaaaaatga ctttcgcaat   360
gaattgttcg aaggttccaa atatctcttg cttttagcag acaagattga cgaaatcaag   420
accatctgtc agtattgcaa gaaaaaggcg accatggtgt tgcgaacaca ggatggactg   480
cccgtttacg atggagaaca gatccagatt ggtggtaacg aaacctatat ctcagtttgc   540
cgtaaacatt attttgcgcc aatgataacc tctaacaagg agcaaaacta tgacaat      597

<210>   2018
<211>   199
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thymidine kinase (tdk)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902966 (e-115)

<400>   2018
Met Ala Gln Leu Tyr Tyr Arg Tyr Gly Thr Met Asn Ser Gly Lys Thr 
1               5                   10                  15      

Ile Glu Ile Leu Lys Val Ala Tyr Asn Tyr Glu Glu Gln Gly Lys Gly 
            20                  25                  30          

Val Val Ile Met Thr Ser Ala Leu Asp Thr Arg Asp Gly Val Gly Tyr 
        35                  40                  45              

Val Ser Ser Arg Ile Gly Met Lys Arg Pro Ala Leu Ala Ile Glu Glu 
    50                  55                  60                  

Thr Thr Asp Ile Phe Gly Tyr Ile Arg Asp Leu Pro Glu Lys Pro Tyr 
65                  70                  75                  80  

Cys Val Leu Val Asp Glu Ala Gln Phe Leu Lys Arg His His Val Tyr 
                85                  90                  95      

Asp Leu Ala Arg Val Val Asp Glu Leu Asp Ile Pro Val Met Ala Phe 
            100                 105                 110         

Gly Leu Lys Asn Asp Phe Arg Asn Glu Leu Phe Glu Gly Ser Lys Tyr 
        115                 120                 125             

Leu Leu Leu Leu Ala Asp Lys Ile Asp Glu Ile Lys Thr Ile Cys Gln 
    130                 135                 140                 

Tyr Cys Lys Lys Lys Ala Thr Met Val Leu Arg Thr Gln Asp Gly Leu 
145                 150                 155                 160 

Pro Val Tyr Asp Gly Glu Gln Ile Gln Ile Gly Gly Asn Glu Thr Tyr 
                165                 170                 175     

Ile Ser Val Cys Arg Lys His Tyr Phe Ala Pro Met Ile Thr Ser Asn 
            180                 185                 190         

Lys Glu Gln Asn Tyr Asp Asn 
        195                 

<210>   2019
<211>   477
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2019
atgacaattg aactaagaga tgttacaatg gaaaattatt ttgatgtttt aaatttggat   60
gtcaaggaat atcaaaaaca attcattgca accaacgcaa ttagtttagc tgaagcatac   120
gtctacacta aaaatggaga ttttgtagct ccattggcag tttatgataa tgatgcaatt   180
ataggttttg tgatgatagc ttatgataaa aagatcggaa ttagtagtgg aaattattta   240
ctatttcgtt ttatgattga taagaatttt caaaatcaag gatattttaa accaattatg   300
gataaagtac tagactatgt tcgaacagcg ccagcaggtt taagcaataa actttggttg   360
tcttatgaac cagaaaatga acaggcaaga ttttgttacc tcagttatgg atttaaagaa   420
actggggaaa tatccgagaa tgaagtagta gcaatctatg atttaacaat tgagaaa      477

<210>   2020
<211>   159
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902967 (3.E-89)

<400>   2020
Met Thr Ile Glu Leu Arg Asp Val Thr Met Glu Asn Tyr Phe Asp Val 
1               5                   10                  15      

Leu Asn Leu Asp Val Lys Glu Tyr Gln Lys Gln Phe Ile Ala Thr Asn 
            20                  25                  30          

Ala Ile Ser Leu Ala Glu Ala Tyr Val Tyr Thr Lys Asn Gly Asp Phe 
        35                  40                  45              

Val Ala Pro Leu Ala Val Tyr Asp Asn Asp Ala Ile Ile Gly Phe Val 
    50                  55                  60                  

Met Ile Ala Tyr Asp Lys Lys Ile Gly Ile Ser Ser Gly Asn Tyr Leu 
65                  70                  75                  80  

Leu Phe Arg Phe Met Ile Asp Lys Asn Phe Gln Asn Gln Gly Tyr Phe 
                85                  90                  95      

Lys Pro Ile Met Asp Lys Val Leu Asp Tyr Val Arg Thr Ala Pro Ala 
            100                 105                 110         

Gly Leu Ser Asn Lys Leu Trp Leu Ser Tyr Glu Pro Glu Asn Glu Gln 
        115                 120                 125             

Ala Arg Phe Cys Tyr Leu Ser Tyr Gly Phe Lys Glu Thr Gly Glu Ile 
    130                 135                 140                 

Ser Glu Asn Glu Val Val Ala Ile Tyr Asp Leu Thr Ile Glu Lys 
145                 150                 155                 

<210>   2021
<211>   1077
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2021
atgaacatct atgatcaact acaagttgta gaagaccgtt atgaagaatt aggagaattg   60
ctgagtgacc ctgatgtcgt ttcagacacc aagcgtttta tggagctttc aaaagaagaa   120
gcttccaatc gtgacaccgt aatagcctac cgtgagtata aacaagtcct tcaaaatatc   180
gtcgatgccg aagagatgat taaggaatca ggcggagatg cggacttgga agaattggcc   240
aagcaagaac tcaaagatgc caaggctgaa aaagaagaat atgaagaaaa actgaaaatt   300
ttgctccttc caaaggatcc aaacgatgac aagaatatca tccttgaaat ccgtggagca   360
gctggtggag acgaagcggc acttttcgct ggagatttgc taactatgta ccaaaagtat   420
gcggaagccc aaggttggcg ctttgaagtc atggaagcct ctatgaatgg tgtcggtggt   480
tttaaagaag tggttgctat ggtttcaggt cagtctgtat actctaagct taagtatgaa   540
tcaggtgccc accgtgtgca acgtgttcct gtgacagaaa gccaaggccg tgttcatact   600

tcgacagcga cagttcttgt tatgccagaa gttgaagagg ttgaatacga cattgatcca   660
aaagaccttc gtgtcgacat ctatcacgcc tctggtgctg gtggacagaa cgtcaataag   720
gttgcgactg ccgttcgtat cgttcacttg ccaaccaata tcaaggttga gatgcaggaa   780
gaacgtaccc agcagaagaa ccgtgagaag gccatgaaaa tcatccgtgc ccgtgttgct   840
gaccactttg ctcagattgc tcaagatgag caggacgctg agcgtaagtc gacaatcggt   900
actggtgacc gttcagaacg gatccgaact tataacttcc cacaaaaccg tgtcacagac   960
caccgtatcg gcttgaccct ccaaaaacta gatacgattt tgtctggtaa attggacgaa   1020

gttgtggatg ccttggtgct ttatgaccaa acacaaaaac tagaagaatt aaacaaa      1077

<210>   2022
<211>   359
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptide chain release factor 1 (prfA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902968 (0.E+01)

<400>   2022
Met Asn Ile Tyr Asp Gln Leu Gln Val Val Glu Asp Arg Tyr Glu Glu 
1               5                   10                  15      

Leu Gly Glu Leu Leu Ser Asp Pro Asp Val Val Ser Asp Thr Lys Arg 
            20                  25                  30          

Phe Met Glu Leu Ser Lys Glu Glu Ala Ser Asn Arg Asp Thr Val Ile 
        35                  40                  45              

Ala Tyr Arg Glu Tyr Lys Gln Val Leu Gln Asn Ile Val Asp Ala Glu 
    50                  55                  60                  

Glu Met Ile Lys Glu Ser Gly Gly Asp Ala Asp Leu Glu Glu Leu Ala 
65                  70                  75                  80  

Lys Gln Glu Leu Lys Asp Ala Lys Ala Glu Lys Glu Glu Tyr Glu Glu 
                85                  90                  95      


Lys Leu Lys Ile Leu Leu Leu Pro Lys Asp Pro Asn Asp Asp Lys Asn 
            100                 105                 110         

Ile Ile Leu Glu Ile Arg Gly Ala Ala Gly Gly Asp Glu Ala Ala Leu 
        115                 120                 125             

Phe Ala Gly Asp Leu Leu Thr Met Tyr Gln Lys Tyr Ala Glu Ala Gln 
    130                 135                 140                 

Gly Trp Arg Phe Glu Val Met Glu Ala Ser Met Asn Gly Val Gly Gly 
145                 150                 155                 160 

Phe Lys Glu Val Val Ala Met Val Ser Gly Gln Ser Val Tyr Ser Lys 
                165                 170                 175     

Leu Lys Tyr Glu Ser Gly Ala His Arg Val Gln Arg Val Pro Val Thr 
            180                 185                 190         

Glu Ser Gln Gly Arg Val His Thr Ser Thr Ala Thr Val Leu Val Met 
        195                 200                 205             

Pro Glu Val Glu Glu Val Glu Tyr Asp Ile Asp Pro Lys Asp Leu Arg 
    210                 215                 220                 

Val Asp Ile Tyr His Ala Ser Gly Ala Gly Gly Gln Asn Val Asn Lys 
225                 230                 235                 240 

Val Ala Thr Ala Val Arg Ile Val His Leu Pro Thr Asn Ile Lys Val 
                245                 250                 255     

Glu Met Gln Glu Glu Arg Thr Gln Gln Lys Asn Arg Glu Lys Ala Met 
            260                 265                 270         

Lys Ile Ile Arg Ala Arg Val Ala Asp His Phe Ala Gln Ile Ala Gln 
        275                 280                 285             

Asp Glu Gln Asp Ala Glu Arg Lys Ser Thr Ile Gly Thr Gly Asp Arg 
    290                 295                 300                 

Ser Glu Arg Ile Arg Thr Tyr Asn Phe Pro Gln Asn Arg Val Thr Asp 
305                 310                 315                 320 

His Arg Ile Gly Leu Thr Leu Gln Lys Leu Asp Thr Ile Leu Ser Gly 
                325                 330                 335     

Lys Leu Asp Glu Val Val Asp Ala Leu Val Leu Tyr Asp Gln Thr Gln 
            340                 345                 350         

Lys Leu Glu Glu Leu Asn Lys 
        355                 

<210>   2023
<211>   837
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2023
atgaaattag ctcaattatt ttcaaatttt gaagaagagt tgataagaca aggagaggaa   60
gcggaaagcc tctcttttgt ctatcgtagt ctgaaaaatc tatcttttac agactttatt   120
tttgccctcc agcaggaggt gacaacagag gaagaaaaac aatttgtaga agatatttac   180
cagcaactag cagctcacaa gccagctcag tacatcattg gacaggcaga tttttatgga   240
atgcatttaa aggtggatga acgggttttg attcctcgtc cagaaacaga ggagttggtg   300
gagcttatcc tggctgaaaa tcctgtgaaa aatcttatgg tcctagatat cggaacaggt   360
agtggagcta ttgctctcgc tctagcaaaa aacagaccag attggtcagt gacggcagca   420
gatatttccc aagatgcttt agatgtagct agcgaaaatg ctaaaaatca aaatcttcaa   480
atatttttaa aaaaatctga ctgttttaca gaaatttctg aaaaatatga tataattgtt   540
tccaatccac cctatatctc tcgtgaagat gagtcagagg taggcttgaa tgtcttgtat   600
tcggagcctc atctagctct ctttgcagat gaggatggcc tagctattta ccgtagaatt   660
gcggaagatg caaaagacta tctcaaagat ggtggtaaga tttaccttga aattggatac   720
aagcaaggtc aaagtgttcc tgaacttttt aggaaacatc ttcctgaaaa gcgagtacga   780
acactcaagg accaatttgg tcaagatagg atggttgtcg ttgatgatgg acaggat      837

<210>   2024
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   HemK protein (hemK)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902969 (e-150)

<400>   2024
Met Lys Leu Ala Gln Leu Phe Ser Asn Phe Glu Glu Glu Leu Ile Arg 
1               5                   10                  15      

Gln Gly Glu Glu Ala Glu Ser Leu Ser Phe Val Tyr Arg Ser Leu Lys 
            20                  25                  30          

Asn Leu Ser Phe Thr Asp Phe Ile Phe Ala Leu Gln Gln Glu Val Thr 
        35                  40                  45              

Thr Glu Glu Glu Lys Gln Phe Val Glu Asp Ile Tyr Gln Gln Leu Ala 
    50                  55                  60                  

Ala His Lys Pro Ala Gln Tyr Ile Ile Gly Gln Ala Asp Phe Tyr Gly 
65                  70                  75                  80  

Met His Leu Lys Val Asp Glu Arg Val Leu Ile Pro Arg Pro Glu Thr 
                85                  90                  95      

Glu Glu Leu Val Glu Leu Ile Leu Ala Glu Asn Pro Val Lys Asn Leu 
            100                 105                 110         

Met Val Leu Asp Ile Gly Thr Gly Ser Gly Ala Ile Ala Leu Ala Leu 
        115                 120                 125             

Ala Lys Asn Arg Pro Asp Trp Ser Val Thr Ala Ala Asp Ile Ser Gln 
    130                 135                 140                 

Asp Ala Leu Asp Val Ala Ser Glu Asn Ala Lys Asn Gln Asn Leu Gln 
145                 150                 155                 160 

Ile Phe Leu Lys Lys Ser Asp Cys Phe Thr Glu Ile Ser Glu Lys Tyr 
                165                 170                 175     

Asp Ile Ile Val Ser Asn Pro Pro Tyr Ile Ser Arg Glu Asp Glu Ser 
            180                 185                 190         

Glu Val Gly Leu Asn Val Leu Tyr Ser Glu Pro His Leu Ala Leu Phe 
        195                 200                 205             

Ala Asp Glu Asp Gly Leu Ala Ile Tyr Arg Arg Ile Ala Glu Asp Ala 
    210                 215                 220                 

Lys Asp Tyr Leu Lys Asp Gly Gly Lys Ile Tyr Leu Glu Ile Gly Tyr 
225                 230                 235                 240 

Lys Gln Gly Gln Ser Val Pro Glu Leu Phe Arg Lys His Leu Pro Glu 
                245                 250                 255     

Lys Arg Val Arg Thr Leu Lys Asp Gln Phe Gly Gln Asp Arg Met Val 
            260                 265                 270         

Val Val Asp Asp Gly Gln Asp 
        275                 

<210>   2025
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2025
ttggtcaaga taggatggtt gtcgttgatg atggacagga ttagacaaga gttggaaaat   60
ggtggagctg tcgttttgcc tacagagaca gtttacggtc tctttgctaa ggcgctagac   120
gaaaaagcag ttgaccatgt ttaccagctt aaacgtcgac gtagagacaa ggcgctcaat   180
ctcaatgttg cctctttaga ggacatcttg tacttttcaa agaatcagcc aacttatctt   240
caaaaacttg tagagatctt tttaccaggt cccttgacca ttattctcga agctaatgac   300
cgagttccct attgggtcaa ttctggcctt gcaactgttg gatttcggat gcctagtcat   360
cccattaccc ttgatttgat tcgagagaca ggtcccttga ttgggccgtc tgccaatatc   420
tcaggtcagg cgagtggagt gacctttaat caaattctag aggattttga ccaagaggtt   480
ctgggtctgg aagacgatgc ttttctaact ggacaggatt caactatttt gaatttgtcg   540
ggagacaagg tgaaaatctt acgtcaaggg gccattaagc gagaagatat tcttgctcgg   600
ttgccaaaga tttcttttga ggaggaa                                       627

<210>   2026
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Sua5/YciO/YrdC family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902970 (e-102)

<400>   2026
Met Val Lys Ile Gly Trp Leu Ser Leu Met Met Asp Arg Ile Arg Gln 
1               5                   10                  15      

Glu Leu Glu Asn Gly Gly Ala Val Val Leu Pro Thr Glu Thr Val Tyr 
            20                  25                  30          

Gly Leu Phe Ala Lys Ala Leu Asp Glu Lys Ala Val Asp His Val Tyr 
        35                  40                  45              

Gln Leu Lys Arg Arg Arg Arg Asp Lys Ala Leu Asn Leu Asn Val Ala 
    50                  55                  60                  

Ser Leu Glu Asp Ile Leu Tyr Phe Ser Lys Asn Gln Pro Thr Tyr Leu 
65                  70                  75                  80  

Gln Lys Leu Val Glu Ile Phe Leu Pro Gly Pro Leu Thr Ile Ile Leu 
                85                  90                  95      

Glu Ala Asn Asp Arg Val Pro Tyr Trp Val Asn Ser Gly Leu Ala Thr 
            100                 105                 110         

Val Gly Phe Arg Met Pro Ser His Pro Ile Thr Leu Asp Leu Ile Arg 
        115                 120                 125             

Glu Thr Gly Pro Leu Ile Gly Pro Ser Ala Asn Ile Ser Gly Gln Ala 
    130                 135                 140                 

Ser Gly Val Thr Phe Asn Gln Ile Leu Glu Asp Phe Asp Gln Glu Val 
145                 150                 155                 160 

Leu Gly Leu Glu Asp Asp Ala Phe Leu Thr Gly Gln Asp Ser Thr Ile 
                165                 170                 175     

Leu Asn Leu Ser Gly Asp Lys Val Lys Ile Leu Arg Gln Gly Ala Ile 
            180                 185                 190         

Lys Arg Glu Asp Ile Leu Ala Arg Leu Pro Lys Ile Ser Phe Glu Glu 
        195                 200                 205             

Glu 
    

<210>   2027
<211>   468
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2027
ttgctcggtt gccaaagatt tcttttgagg aggaatgaga tgctaagaga tttaagagaa   60
actgatgtga aagctatatg tgacatcaac caagaggctt tgggttatac ttttagtcca   120
gaggaaacgg ctagccaact agctagactg tctcaggatt cccatcattt cctacttggc   180
tatgaggatg cagctaatca tgtcttactt ggatatgtcc acgctgaagt ttacgaatca   240
ctctattcca aagcaggatt taatatctta gctttagcag tttcacctca agcgcaaggt   300
caaggtattg gtaaaagttt actacaaggg ttggaagaag aagcaaaaag atgtggttat   360
gggtttatcc gcttaaattc tgccaatcat cgtctgggtg ctcatgcatt ttatgaaaaa   420
gttggctata cttgtgataa aatgcagaaa cggtttattc gcatctgt                468

<210>   2028
<211>   156
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902971 (9.E-79)

<400>   2028
Met Leu Gly Cys Gln Arg Phe Leu Leu Arg Arg Asn Glu Met Leu Arg 
1               5                   10                  15      

Asp Leu Arg Glu Thr Asp Val Lys Ala Ile Cys Asp Ile Asn Gln Glu 
            20                  25                  30          

Ala Leu Gly Tyr Thr Phe Ser Pro Glu Glu Thr Ala Ser Gln Leu Ala 
        35                  40                  45              

Arg Leu Ser Gln Asp Ser His His Phe Leu Leu Gly Tyr Glu Asp Ala 
    50                  55                  60                  

Ala Asn His Val Leu Leu Gly Tyr Val His Ala Glu Val Tyr Glu Ser 
65                  70                  75                  80  

Leu Tyr Ser Lys Ala Gly Phe Asn Ile Leu Ala Leu Ala Val Ser Pro 
                85                  90                  95      

Gln Ala Gln Gly Gln Gly Ile Gly Lys Ser Leu Leu Gln Gly Leu Glu 
            100                 105                 110         

Glu Glu Ala Lys Arg Cys Gly Tyr Gly Phe Ile Arg Leu Asn Ser Ala 
        115                 120                 125             

Asn His Arg Leu Gly Ala His Ala Phe Tyr Glu Lys Val Gly Tyr Thr 
    130                 135                 140                 

Cys Asp Lys Met Gln Lys Arg Phe Ile Arg Ile Cys 
145                 150                 155     

<210>   2029
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2029
atgatttttg acaaagatga ttttaaagca tatgatgctg atctctggaa tgctattgcc   60
aaagaagaag aacgccaaca aaataatatc gagttaattg cttcggaaaa cgtagtttcc   120
aaggctgtta tggcagctca agggtctatc ttgacaaata aatatgccga gggttaccca   180

ggacgccgtt attatggtgg aactgatgta gtagacgttg tagagactct tgctattgaa   240
cgcgcaaaag aaattttcgg tgctaaattt gccaatgttc aaccacattc aggaagccaa   300
gctaactgtg cggcttacat gtccttgatt gagccaggtg atacggttat gggaatggat   360
ttggcatcag gtggtcattt gactcatggg gctcctgtta gcttctctgg tcaaacctac   420
aactttgttt cttatagtgt tgatcctaaa acggaactct tagactttga tgctatcttg   480
aaacaagccc aagaagtaaa accaaaactg attgtagctg gtgcttcagc ctattctcaa   540
attatcgatt tttcaaaatt ccgtgaaatc gcagatgctg tcggtgcgaa gctcatggtg   600
gacatggccc atatcgctgg cttggttgcg gctggccttc atccaagccc agttccatac   660
gctcatatca caacaacaac gacccacaaa acccttcgtg gacctcgtgg tggtttgatt   720
ttgaccaatg acgaagaact tgctaaaaaa atcaattcag ctattttccc aggtattcag   780
ggcggtcctt tagagcatgt tgtggcggct aaggcagttt ccttcaaaga agttttggat   840
ccagccttca aggaatatgc tgccaatgta attaagaaca gcaaggctat ggcagatgtc   900
ttcttgcaag accctgattt ccgtattatt tcaggtggaa ctgaaaacca tctcttcctt   960
gttgatgtga ctaaagttgt agaaaacggc aaagttgctc aaaacttgtt ggatgaagtc   1020
aatattacct taaataaaaa ctcaatccct tacgaaagct tgtcaccatt caagacaagt   1080
gggattcgta tcggagcagc agccattact gcacgtggat ttggtgaaga agaaagtcgc   1140
aaagtggctg aactcatcat taaaaccctt aagaattcag aaaatgaggc tgtattagaa   1200
gaagtgagaa gtgcagtcaa agaattgaca gatgccttcc cattatacga ggac         1254

<210>   2030
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   serine hydroxymethyltransferase (glyA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902972 (0.E+01)

<400>   2030
Met Ile Phe Asp Lys Asp Asp Phe Lys Ala Tyr Asp Ala Asp Leu Trp 
1               5                   10                  15      

Asn Ala Ile Ala Lys Glu Glu Glu Arg Gln Gln Asn Asn Ile Glu Leu 
            20                  25                  30          

Ile Ala Ser Glu Asn Val Val Ser Lys Ala Val Met Ala Ala Gln Gly 
        35                  40                  45              

Ser Ile Leu Thr Asn Lys Tyr Ala Glu Gly Tyr Pro Gly Arg Arg Tyr 
    50                  55                  60                  

Tyr Gly Gly Thr Asp Val Val Asp Val Val Glu Thr Leu Ala Ile Glu 
65                  70                  75                  80  

Arg Ala Lys Glu Ile Phe Gly Ala Lys Phe Ala Asn Val Gln Pro His 
                85                  90                  95      

Ser Gly Ser Gln Ala Asn Cys Ala Ala Tyr Met Ser Leu Ile Glu Pro 
            100                 105                 110         

Gly Asp Thr Val Met Gly Met Asp Leu Ala Ser Gly Gly His Leu Thr 
        115                 120                 125             

His Gly Ala Pro Val Ser Phe Ser Gly Gln Thr Tyr Asn Phe Val Ser 
    130                 135                 140                 

Tyr Ser Val Asp Pro Lys Thr Glu Leu Leu Asp Phe Asp Ala Ile Leu 
145                 150                 155                 160 

Lys Gln Ala Gln Glu Val Lys Pro Lys Leu Ile Val Ala Gly Ala Ser 
                165                 170                 175     

Ala Tyr Ser Gln Ile Ile Asp Phe Ser Lys Phe Arg Glu Ile Ala Asp 
            180                 185                 190         

Ala Val Gly Ala Lys Leu Met Val Asp Met Ala His Ile Ala Gly Leu 
        195                 200                 205             

Val Ala Ala Gly Leu His Pro Ser Pro Val Pro Tyr Ala His Ile Thr 
    210                 215                 220                 

Thr Thr Thr Thr His Lys Thr Leu Arg Gly Pro Arg Gly Gly Leu Ile 
225                 230                 235                 240 

Leu Thr Asn Asp Glu Glu Leu Ala Lys Lys Ile Asn Ser Ala Ile Phe 
                245                 250                 255     

Pro Gly Ile Gln Gly Gly Pro Leu Glu His Val Val Ala Ala Lys Ala 
            260                 265                 270         

Val Ser Phe Lys Glu Val Leu Asp Pro Ala Phe Lys Glu Tyr Ala Ala 
        275                 280                 285             

Asn Val Ile Lys Asn Ser Lys Ala Met Ala Asp Val Phe Leu Gln Asp 
    290                 295                 300                 

Pro Asp Phe Arg Ile Ile Ser Gly Gly Thr Glu Asn His Leu Phe Leu 
305                 310                 315                 320 

Val Asp Val Thr Lys Val Val Glu Asn Gly Lys Val Ala Gln Asn Leu 
                325                 330                 335     

Leu Asp Glu Val Asn Ile Thr Leu Asn Lys Asn Ser Ile Pro Tyr Glu 
            340                 345                 350         

Ser Leu Ser Pro Phe Lys Thr Ser Gly Ile Arg Ile Gly Ala Ala Ala 
        355                 360                 365             

Ile Thr Ala Arg Gly Phe Gly Glu Glu Glu Ser Arg Lys Val Ala Glu 
    370                 375                 380                 

Leu Ile Ile Lys Thr Leu Lys Asn Ser Glu Asn Glu Ala Val Leu Glu 
385                 390                 395                 400 

Glu Val Arg Ser Ala Val Lys Glu Leu Thr Asp Ala Phe Pro Leu Tyr 
                405                 410                 415     

Glu Asp 
        

<210>   2031
<211>   1005
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2031
atgccttccc attatacgag gactaaaact tttatggaca tttatattaa gaaagccatt   60
attcaccagt tcagtccgga tgataccgaa ctgttcttag cagataagtt tctcaatatt   120
actccaaaaa tcgaagaata cctgcgtaaa aaaattgaac atgtgtattc agatgaagcc   180
aagactggga ttttcgaaga agaaaatccc ttcttcaatc atattacaga cgatttgttg   240
gagacatcag taacgctggc taatctctgg aaagaggagt ttagcatttc tgaaaatctc   300
aagaccaatg acttgatttt tgtgcaattt tctaaagaag gtgtagaaca tttcgctttc   360
ttgcgaattg ccctgcggga gaccttgacc cacctcggag gagaagttga taatccaatc   420
aagctaactc agaataacct gcctggattt ggaacaggag ctgatgaggc cttggtggtc   480
aatcttcaga gtagcaagta tcacctgatt gaaaaacgaa tcaagtacaa cgggactttt   540
ttgaactatt tttcagataa tcttcttgct gtcgctccta agatttctcc taaaaaatct   600
atcaaggaac tggaaaaaac agcccagaga attgctaaat cttttaacac agatgatttt   660
caatttcaat ccaaggtcaa atcagctatt ttcaacaacc tagaagaaag caatgaattg   720
tcacctgaga aattggctaa tgaccttttt gacaacaatc tgacggctcg tttgagcttt   780
attgaccaag tcaaagaagc cgtaccagaa cctgttcaat ttgatgaaat tgatgccagt   840
cgccaattaa agaaatttga aaaccaaaaa ctctccttat caaatggaat tgagctcatc   900
gttcccaata acgtctatca agacgccgag tctgttgagt ttatccaaaa cgaaaatgga   960
acctactcta tcttaatcaa aaatatcgag gatatccaaa gtaaa                   1005

<210>   2032
<211>   335
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902973 (0.E+01)

<400>   2032
Met Pro Ser His Tyr Thr Arg Thr Lys Thr Phe Met Asp Ile Tyr Ile 
1               5                   10                  15      

Lys Lys Ala Ile Ile His Gln Phe Ser Pro Asp Asp Thr Glu Leu Phe 
            20                  25                  30          

Leu Ala Asp Lys Phe Leu Asn Ile Thr Pro Lys Ile Glu Glu Tyr Leu 
        35                  40                  45              

Arg Lys Lys Ile Glu His Val Tyr Ser Asp Glu Ala Lys Thr Gly Ile 
    50                  55                  60                  

Phe Glu Glu Glu Asn Pro Phe Phe Asn His Ile Thr Asp Asp Leu Leu 
65                  70                  75                  80  

Glu Thr Ser Val Thr Leu Ala Asn Leu Trp Lys Glu Glu Phe Ser Ile 
                85                  90                  95      

Ser Glu Asn Leu Lys Thr Asn Asp Leu Ile Phe Val Gln Phe Ser Lys 
            100                 105                 110         

Glu Gly Val Glu His Phe Ala Phe Leu Arg Ile Ala Leu Arg Glu Thr 
        115                 120                 125             

Leu Thr His Leu Gly Gly Glu Val Asp Asn Pro Ile Lys Leu Thr Gln 
    130                 135                 140                 

Asn Asn Leu Pro Gly Phe Gly Thr Gly Ala Asp Glu Ala Leu Val Val 
145                 150                 155                 160 

Asn Leu Gln Ser Ser Lys Tyr His Leu Ile Glu Lys Arg Ile Lys Tyr 
                165                 170                 175     

Asn Gly Thr Phe Leu Asn Tyr Phe Ser Asp Asn Leu Leu Ala Val Ala 
            180                 185                 190         

Pro Lys Ile Ser Pro Lys Lys Ser Ile Lys Glu Leu Glu Lys Thr Ala 
        195                 200                 205             

Gln Arg Ile Ala Lys Ser Phe Asn Thr Asp Asp Phe Gln Phe Gln Ser 
    210                 215                 220                 

Lys Val Lys Ser Ala Ile Phe Asn Asn Leu Glu Glu Ser Asn Glu Leu 
225                 230                 235                 240 

Ser Pro Glu Lys Leu Ala Asn Asp Leu Phe Asp Asn Asn Leu Thr Ala 
                245                 250                 255     

Arg Leu Ser Phe Ile Asp Gln Val Lys Glu Ala Val Pro Glu Pro Val 
            260                 265                 270         

Gln Phe Asp Glu Ile Asp Ala Ser Arg Gln Leu Lys Lys Phe Glu Asn 
        275                 280                 285             

Gln Lys Leu Ser Leu Ser Asn Gly Ile Glu Leu Ile Val Pro Asn Asn 
    290                 295                 300                 

Val Tyr Gln Asp Ala Glu Ser Val Glu Phe Ile Gln Asn Glu Asn Gly 
305                 310                 315                 320 

Thr Tyr Ser Ile Leu Ile Lys Asn Ile Glu Asp Ile Gln Ser Lys 
                325                 330                 335 

<210>   2033
<211>   612
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2033
atgtttaaac gaattcgaag agtgcttgta ctagcagtct tcctttttgc tggctataaa   60
gcttaccgcg ttcatcaaga tgtcaaacaa gtcatgacct atcaacccat ggtgcgagaa   120
atattgagtg aacaagacac cccagcaaac gaagagcttg tgcttgctat gatttatact   180
gaaacaaaag gaaaagaagg cgatgttatg cagtctagtg agtctgcaag tggttccacc   240
aacaccatca atgataatgc ctctagcatt cggcaaggca ttcaaactct gacaggcaat   300
ctctatctgg cgcagaagaa gggggtagat atctggacag ctgttcaagc ctataatttt   360
ggacctgcct atatcgattt tatcgcccaa aatggcaagg aaaataccct ggctctagcc   420
aaacagtact ctcgtgagac tgttgccccc ttgcttggta ataggactgg aaagacttat   480
agttatattc accccatttc catttttcac ggtgctgaac tctatgtaaa tggaggaaac   540
tattattatt ctagacaggt acgacttaac ctttacatca tcaaatgttt cactctcttt   600
tcaacatctg gc                                                       612

<210>   2034
<211>   204
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902974 (e-114)

<400>   2034
Met Phe Lys Arg Ile Arg Arg Val Leu Val Leu Ala Val Phe Leu Phe 
1               5                   10                  15      

Ala Gly Tyr Lys Ala Tyr Arg Val His Gln Asp Val Lys Gln Val Met 
            20                  25                  30          

Thr Tyr Gln Pro Met Val Arg Glu Ile Leu Ser Glu Gln Asp Thr Pro 
        35                  40                  45              

Ala Asn Glu Glu Leu Val Leu Ala Met Ile Tyr Thr Glu Thr Lys Gly 
    50                  55                  60                  

Lys Glu Gly Asp Val Met Gln Ser Ser Glu Ser Ala Ser Gly Ser Thr 
65                  70                  75                  80  

Asn Thr Ile Asn Asp Asn Ala Ser Ser Ile Arg Gln Gly Ile Gln Thr 
                85                  90                  95      

Leu Thr Gly Asn Leu Tyr Leu Ala Gln Lys Lys Gly Val Asp Ile Trp 
            100                 105                 110         

Thr Ala Val Gln Ala Tyr Asn Phe Gly Pro Ala Tyr Ile Asp Phe Ile 
        115                 120                 125             

Ala Gln Asn Gly Lys Glu Asn Thr Leu Ala Leu Ala Lys Gln Tyr Ser 
    130                 135                 140                 

Arg Glu Thr Val Ala Pro Leu Leu Gly Asn Arg Thr Gly Lys Thr Tyr 
145                 150                 155                 160 

Ser Tyr Ile His Pro Ile Ser Ile Phe His Gly Ala Glu Leu Tyr Val 
                165                 170                 175     

Asn Gly Gly Asn Tyr Tyr Tyr Ser Arg Gln Val Arg Leu Asn Leu Tyr 
            180                 185                 190         

Ile Ile Lys Cys Phe Thr Leu Phe Ser Thr Ser Gly 
        195                 200                 

<210>   2035
<211>   972
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2035
atgagaaaga aactctttct gactagcgct gcgatcttgt gggcagtaac agctatgaat   60
agcgtccatg cagcaacaga tgttcaaaaa gttatcgatg aaacctatgt ccaacctgaa   120
tatgtcctag gttcctccct atctgaagac caaaaaaatc aaactcttaa aaaactgggc   180
tacaatgcct caacagatac caaagaactc aagaccatga cacctgatgt ttattctaaa   240
atcatgaatg tggccaatga ctctagctta cagttgtatt catcagccaa gattcaaaag   300
ctaggtgaca aatcgccact tgaggtcaag attgaaacac cagaaaatat cactaaggtg   360
actcaggata tgtaccgaaa cgcagcagta acgctgggta tggaacatgc caaaatcact   420
gtagcagccc ctattccagt tacaggagaa agtgctttag cagggattta ctattcgcta   480
gaggctaatg gagccaaggt gccacaagct aataaagatt tggctcaaga agagctaaaa   540
gctttgtcag atatcaatgc tgaaaacaag gacaaatcag gctatgatgc taataaatta   600
aacgttgccc tagctgatat caagtcagga ctcgccaaag ctaaagaaag taagggaaat   660
ctgacagaag aagatatccg caagattgtt gaagatacct taaaaaatta caaacttgat   720
caggtcataa caggaaacca gatcaatatc atcatcaatt ttgccttgaa tctctcaaag   780
agtgatatcc tcagcaatgc agatttcact aaaaccctaa atgaccttaa acaaagcatc   840
gtatcacaag ctggcgacag ttttaaaaat atcaacctta actttgatgc ggataaggcg   900
ctagaggacg gtggtaactt cttaagctcc ctctggcaag cccttgtcaa cttcttcaag   960
agttttggtt ct                                                       972

<210>   2036
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902975 (e-180)

<400>   2036
Met Arg Lys Lys Leu Phe Leu Thr Ser Ala Ala Ile Leu Trp Ala Val 
1               5                   10                  15      

Thr Ala Met Asn Ser Val His Ala Ala Thr Asp Val Gln Lys Val Ile 
            20                  25                  30          

Asp Glu Thr Tyr Val Gln Pro Glu Tyr Val Leu Gly Ser Ser Leu Ser 
        35                  40                  45              

Glu Asp Gln Lys Asn Gln Thr Leu Lys Lys Leu Gly Tyr Asn Ala Ser 
    50                  55                  60                  

Thr Asp Thr Lys Glu Leu Lys Thr Met Thr Pro Asp Val Tyr Ser Lys 
65                  70                  75                  80  

Ile Met Asn Val Ala Asn Asp Ser Ser Leu Gln Leu Tyr Ser Ser Ala 
                85                  90                  95      

Lys Ile Gln Lys Leu Gly Asp Lys Ser Pro Leu Glu Val Lys Ile Glu 
            100                 105                 110         

Thr Pro Glu Asn Ile Thr Lys Val Thr Gln Asp Met Tyr Arg Asn Ala 
        115                 120                 125             

Ala Val Thr Leu Gly Met Glu His Ala Lys Ile Thr Val Ala Ala Pro 
    130                 135                 140                 

Ile Pro Val Thr Gly Glu Ser Ala Leu Ala Gly Ile Tyr Tyr Ser Leu 
145                 150                 155                 160 

Glu Ala Asn Gly Ala Lys Val Pro Gln Ala Asn Lys Asp Leu Ala Gln 
                165                 170                 175     

Glu Glu Leu Lys Ala Leu Ser Asp Ile Asn Ala Glu Asn Lys Asp Lys 
            180                 185                 190         

Ser Gly Tyr Asp Ala Asn Lys Leu Asn Val Ala Leu Ala Asp Ile Lys 
        195                 200                 205             

Ser Gly Leu Ala Lys Ala Lys Glu Ser Lys Gly Asn Leu Thr Glu Glu 
    210                 215                 220                 

Asp Ile Arg Lys Ile Val Glu Asp Thr Leu Lys Asn Tyr Lys Leu Asp 
225                 230                 235                 240 

Gln Val Ile Thr Gly Asn Gln Ile Asn Ile Ile Ile Asn Phe Ala Leu 
                245                 250                 255     

Asn Leu Ser Lys Ser Asp Ile Leu Ser Asn Ala Asp Phe Thr Lys Thr 
            260                 265                 270         

Leu Asn Asp Leu Lys Gln Ser Ile Val Ser Gln Ala Gly Asp Ser Phe 
        275                 280                 285             

Lys Asn Ile Asn Leu Asn Phe Asp Ala Asp Lys Ala Leu Glu Asp Gly 
    290                 295                 300                 

Gly Asn Phe Leu Ser Ser Leu Trp Gln Ala Leu Val Asn Phe Phe Lys 
305                 310                 315                 320 

Ser Phe Gly Ser 
                

<210>   2037
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2037
ttgtcaactt cttcaagagt tttggttctt aagaaatttc atggtataat ggatggtaac   60
cgtaacgttg ccgtcttttt tgtcggccaa                                    90

<210>   2038
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2038
Met Ser Thr Ser Ser Arg Val Leu Val Leu Lys Lys Phe His Gly Ile 
1               5                   10                  15      

Met Asp Gly Asn Arg Asn Val Ala Val Phe Phe Val Gly Gln 
            20                  25                  30  

<210>   2039
<211>   1629
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2039
atgttaaaga aaaatgatat tgtagaagtt gaaattgttg atttgaccca tgaaggggca   60
ggagttgcca aggtagatgg tttggtcttt tttgtagaga atgctttacc gagtgaaaaa   120
attctcatgc gtgtcctcaa ggtcaataaa aagattggct ttggaaaagt tgaaaaatac   180
cttgtccagt caccacaccg taatcaagat ctagatttgg cttacctgcg ttcaggaatc   240
gcggatttag gacacctttc ttatccagaa cagctcaagt ttaaaaccaa gcaagtcaag   300
gacagtctct acaagattgc tggaattgca gatgtagaag ttgctgaaac gcttggtatg   360
gaacatccag tcaagtatcg caataaggcg caggtgcccg ttcgtcgagt gaatggtgtc   420
ttggaaacag gatttttccg taagaattcg cataacctca tgccccttga agatttcttt   480
atccaggatc ctgtcattga ccaagtcgta gtagctcttc gagacctgct ccgtcgtttt   540
gatttaaaac cttatgacga aaaggaacag tctggattga ttcggaatct tgtggtgcgt   600
cgtggtcact attcaggaca aatcatggtc gttttggtga caactcgtcc aaaagttttt   660
cgtgttgacc aattgattga acaagttatc aagcagttcc cagagattgt gtctgtcatg   720
caaaatatca acgaccagaa taccaatgcg atttttggta aggagtggcg cactctttat   780
ggtcaagact atattacgga ccagatgttg ggaaatgact tccaaatcgc tggcccagcc   840
ttttaccaag tcaatactga aatggcggag aaactctatc aaacagccat tgactttgca   900
gagttaaaaa aagatgatgt gattattgat gcctattctg gtattggaac cattggttta   960
tcagtcgcca agcatgtcaa agaagtctac ggtgttgaac tgattccaga agcagtagag   1020
aatagccaga agaatgcttc tttgaacaag attactaatg cccactatgt ctgtgacacg   1080
gctgaaaatg ccatgaagaa atggctcaag gaaggtattc aaccaaccgt tatcttggtt   1140
gatcctccac gcaagggctt gacagaaagc tttatcaaag caagcgccca aacaggagcc   1200
gatcgcatcg cctatatctc ctgcaatgtc gcaaccatgg cgcgtgatat taaactatac   1260
caagagttgg gatatgaatt gaagaaagtc cagccggtgg atctatttcc tcaaacgcat   1320
cacgtcgaga cggtagcact tttgtccaaa ctcgatgtcg ataagcacat aagtgttgaa   1380
attgagctgg atgagatgga tttgacaagt gcggagagca aagcaacata tgctcaaatc   1440
aaagaatatg tttggaataa atttgaatta aaagtttcga cattatatat tgcacagata   1500
aaaaagaaat gtggaataga attacgagaa cattacaaca agtctaaaaa ggataaacaa   1560
attattccac agtgtacacc tgaaaaagaa gaagccatca tggatgcttt gagacacttc   1620
aaaatgatt                                                           1629

<210>   2040
<211>   543
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RNA methyltransferase, TrmA family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902976 (0.E+01)

<400>   2040
Met Leu Lys Lys Asn Asp Ile Val Glu Val Glu Ile Val Asp Leu Thr 
1               5                   10                  15      

His Glu Gly Ala Gly Val Ala Lys Val Asp Gly Leu Val Phe Phe Val 
            20                  25                  30          

Glu Asn Ala Leu Pro Ser Glu Lys Ile Leu Met Arg Val Leu Lys Val 
        35                  40                  45              

Asn Lys Lys Ile Gly Phe Gly Lys Val Glu Lys Tyr Leu Val Gln Ser 
    50                  55                  60                  

Pro His Arg Asn Gln Asp Leu Asp Leu Ala Tyr Leu Arg Ser Gly Ile 
65                  70                  75                  80  

Ala Asp Leu Gly His Leu Ser Tyr Pro Glu Gln Leu Lys Phe Lys Thr 
                85                  90                  95      

Lys Gln Val Lys Asp Ser Leu Tyr Lys Ile Ala Gly Ile Ala Asp Val 
            100                 105                 110         

Glu Val Ala Glu Thr Leu Gly Met Glu His Pro Val Lys Tyr Arg Asn 
        115                 120                 125             

Lys Ala Gln Val Pro Val Arg Arg Val Asn Gly Val Leu Glu Thr Gly 
    130                 135                 140                 

Phe Phe Arg Lys Asn Ser His Asn Leu Met Pro Leu Glu Asp Phe Phe 
145                 150                 155                 160 

Ile Gln Asp Pro Val Ile Asp Gln Val Val Val Ala Leu Arg Asp Leu 
                165                 170                 175     

Leu Arg Arg Phe Asp Leu Lys Pro Tyr Asp Glu Lys Glu Gln Ser Gly 
            180                 185                 190         

Leu Ile Arg Asn Leu Val Val Arg Arg Gly His Tyr Ser Gly Gln Ile 
        195                 200                 205             

Met Val Val Leu Val Thr Thr Arg Pro Lys Val Phe Arg Val Asp Gln 
    210                 215                 220                 

Leu Ile Glu Gln Val Ile Lys Gln Phe Pro Glu Ile Val Ser Val Met 
225                 230                 235                 240 

Gln Asn Ile Asn Asp Gln Asn Thr Asn Ala Ile Phe Gly Lys Glu Trp 
                245                 250                 255     

Arg Thr Leu Tyr Gly Gln Asp Tyr Ile Thr Asp Gln Met Leu Gly Asn 
            260                 265                 270         

Asp Phe Gln Ile Ala Gly Pro Ala Phe Tyr Gln Val Asn Thr Glu Met 
        275                 280                 285             

Ala Glu Lys Leu Tyr Gln Thr Ala Ile Asp Phe Ala Glu Leu Lys Lys 
    290                 295                 300                 

Asp Asp Val Ile Ile Asp Ala Tyr Ser Gly Ile Gly Thr Ile Gly Leu 
305                 310                 315                 320 

Ser Val Ala Lys His Val Lys Glu Val Tyr Gly Val Glu Leu Ile Pro 
                325                 330                 335     

Glu Ala Val Glu Asn Ser Gln Lys Asn Ala Ser Leu Asn Lys Ile Thr 
            340                 345                 350         

Asn Ala His Tyr Val Cys Asp Thr Ala Glu Asn Ala Met Lys Lys Trp 
        355                 360                 365             

Leu Lys Glu Gly Ile Gln Pro Thr Val Ile Leu Val Asp Pro Pro Arg 
    370                 375                 380                 

Lys Gly Leu Thr Glu Ser Phe Ile Lys Ala Ser Ala Gln Thr Gly Ala 
385                 390                 395                 400 

Asp Arg Ile Ala Tyr Ile Ser Cys Asn Val Ala Thr Met Ala Arg Asp 
                405                 410                 415     

Ile Lys Leu Tyr Gln Glu Leu Gly Tyr Glu Leu Lys Lys Val Gln Pro 
            420                 425                 430         

Val Asp Leu Phe Pro Gln Thr His His Val Glu Thr Val Ala Leu Leu 
        435                 440                 445             

Ser Lys Leu Asp Val Asp Lys His Ile Ser Val Glu Ile Glu Leu Asp 
    450                 455                 460                 

Glu Met Asp Leu Thr Ser Ala Glu Ser Lys Ala Thr Tyr Ala Gln Ile 
465                 470                 475                 480 

Lys Glu Tyr Val Trp Asn Lys Phe Glu Leu Lys Val Ser Thr Leu Tyr 
                485                 490                 495     

Ile Ala Gln Ile Lys Lys Lys Cys Gly Ile Glu Leu Arg Glu His Tyr 
            500                 505                 510         

Asn Lys Ser Lys Lys Asp Lys Gln Ile Ile Pro Gln Cys Thr Pro Glu 
        515                 520                 525             

Lys Glu Glu Ala Ile Met Asp Ala Leu Arg His Phe Lys Met Ile 
    530                 535                 540             

<210>   2041
<211>   216
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2041
atggcactta actataaacc attatggata cagttagcaa aaaaaggact aaagaaaaca   60
gatgtaatag ctatggcagg acttacaaca aatgttatgg cacaaatggg aaaggataaa   120
ccaattacat ttaagaattt agaaagaata tgtaaggctt tatcttgcac tcctaatgat   180
attattagtt ttgaagataa ttttagtgac gaggaa                             216

<210>   2042
<211>   72
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902977 (1.E-37)

<400>   2042
Met Ala Leu Asn Tyr Lys Pro Leu Trp Ile Gln Leu Ala Lys Lys Gly 
1               5                   10                  15      

Leu Lys Lys Thr Asp Val Ile Ala Met Ala Gly Leu Thr Thr Asn Val 
            20                  25                  30          

Met Ala Gln Met Gly Lys Asp Lys Pro Ile Thr Phe Lys Asn Leu Glu 
        35                  40                  45              

Arg Ile Cys Lys Ala Leu Ser Cys Thr Pro Asn Asp Ile Ile Ser Phe 
    50                  55                  60                  

Glu Asp Asn Phe Ser Asp Glu Glu 
65                  70          

<210>   2043
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2043
atgaatgatg tagcaataat ccttgaaaca aaatcagaag aaagagatat tagcaaacaa   60
atttttattg atgagttaat gaaaaatata gacataatt                          99

<210>   2044
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2044
Met Asn Asp Val Ala Ile Ile Leu Glu Thr Lys Ser Glu Glu Arg Asp 
1               5                   10                  15      

Ile Ser Lys Gln Ile Phe Ile Asp Glu Leu Met Lys Asn Ile Asp Ile 
            20                  25                  30          

Ile 
    

<210>   2045
<211>   1023
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2045
atgaaaaaca aattttttct aatagctatt ttagctatgt gtatagtttt tagcgcttgt   60
tcttctaatt ctgttaaaaa tgaagaaaat acttctaaag agcatgcgcc tgataaaata   120
gttttagatc atgctttcgg tcaaactata ttagataaaa aacctgaaag agttgcaact   180
attgcttggg gaaatcatga tgtagcatta gctttaggaa tagttcctgt tggattttca   240
aaagcaaatt acggtgtaag tgctgataaa ggagttttac catggacaga agaaaaaatc   300

aaagaactaa atggtaaagc taacctattt gacgatttgg atggacttaa ctttgaagca   360
atatcaaatt ctaaaccaga tgttatctta gcaggttatt ctggtataac taaagaagat   420
tatgacactc tatcaaaaat tgctcctgta gcagcataca aatctaaacc ttggcaaact   480
ttatggagag atatgattaa aattgattca aaagccttag gtatggaaaa agaaggtgat   540
gagttaatca aaaatactga agctcgtata tccaaagaat tagaaaaaca tccagaaatc   600
aaaggaaaaa tcaaaggaaa aaaagtatta tttactatga ttaatgctgc agatacatca   660
aaattctgga tttatactag caaagatcca agagcaaatt atttaacaga tttaggtcta   720
gttttccctg aatcattaaa agaatttgag agtgaagata gttttgcaaa ggaaatttct   780
gcagaagaag caaataagat aaatgatgct gatgtaatca taacttatgg tgatgataaa   840
actcttgaag ctttacaaaa agatcctctt ttaggtaaaa taaatgcaat taaaaatggt   900
gccgttgctg taattccaga taatacaccg ttagcagcct catgcactcc aacaccactt   960
tcaataaact atactattga agaataccta aatcttttag gaaatgcatg caaaaatgcg   1020
aaa                                                                 1023

<210>   2046
<211>   341
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron-compound ABC transporter, iron compound-binding protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902978 (0.E+01)

<400>   2046
Met Lys Asn Lys Phe Phe Leu Ile Ala Ile Leu Ala Met Cys Ile Val 
1               5                   10                  15      

Phe Ser Ala Cys Ser Ser Asn Ser Val Lys Asn Glu Glu Asn Thr Ser 
            20                  25                  30          

Lys Glu His Ala Pro Asp Lys Ile Val Leu Asp His Ala Phe Gly Gln 
        35                  40                  45              

Thr Ile Leu Asp Lys Lys Pro Glu Arg Val Ala Thr Ile Ala Trp Gly 
    50                  55                  60                  

Asn His Asp Val Ala Leu Ala Leu Gly Ile Val Pro Val Gly Phe Ser 
65                  70                  75                  80  


Lys Ala Asn Tyr Gly Val Ser Ala Asp Lys Gly Val Leu Pro Trp Thr 
                85                  90                  95      

Glu Glu Lys Ile Lys Glu Leu Asn Gly Lys Ala Asn Leu Phe Asp Asp 
            100                 105                 110         

Leu Asp Gly Leu Asn Phe Glu Ala Ile Ser Asn Ser Lys Pro Asp Val 
        115                 120                 125             

Ile Leu Ala Gly Tyr Ser Gly Ile Thr Lys Glu Asp Tyr Asp Thr Leu 
    130                 135                 140                 

Ser Lys Ile Ala Pro Val Ala Ala Tyr Lys Ser Lys Pro Trp Gln Thr 
145                 150                 155                 160 

Leu Trp Arg Asp Met Ile Lys Ile Asp Ser Lys Ala Leu Gly Met Glu 
                165                 170                 175     

Lys Glu Gly Asp Glu Leu Ile Lys Asn Thr Glu Ala Arg Ile Ser Lys 
            180                 185                 190         

Glu Leu Glu Lys His Pro Glu Ile Lys Gly Lys Ile Lys Gly Lys Lys 
        195                 200                 205             

Val Leu Phe Thr Met Ile Asn Ala Ala Asp Thr Ser Lys Phe Trp Ile 
    210                 215                 220                 

Tyr Thr Ser Lys Asp Pro Arg Ala Asn Tyr Leu Thr Asp Leu Gly Leu 
225                 230                 235                 240 

Val Phe Pro Glu Ser Leu Lys Glu Phe Glu Ser Glu Asp Ser Phe Ala 
                245                 250                 255     

Lys Glu Ile Ser Ala Glu Glu Ala Asn Lys Ile Asn Asp Ala Asp Val 
            260                 265                 270         

Ile Ile Thr Tyr Gly Asp Asp Lys Thr Leu Glu Ala Leu Gln Lys Asp 
        275                 280                 285             

Pro Leu Leu Gly Lys Ile Asn Ala Ile Lys Asn Gly Ala Val Ala Val 
    290                 295                 300                 

Ile Pro Asp Asn Thr Pro Leu Ala Ala Ser Cys Thr Pro Thr Pro Leu 
305                 310                 315                 320 

Ser Ile Asn Tyr Thr Ile Glu Glu Tyr Leu Asn Leu Leu Gly Asn Ala 
                325                 330                 335     

Cys Lys Asn Ala Lys 
            340     

<210>   2047
<211>   1017
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2047
atgcatgcaa aaatgcgaaa taaaaaacaa ataaacctag gcataatttt tataatctgc   60
ctaggtcttc ttattacaat atttttgtca ttaaagcttg gaacaaaaga aattaatatc   120
agagattttt tagcagcttt tggaatgggt aatacaaatg atgattttat taaatcaatt   180
atatataaaa gaatacctag aactattttt gcaattttag caggttctag tcttgccata   240
agcggtgtat tgatgcaatc agttactaga aacccaatag ctgatccagg tatactcggt   300
ataaacacag gagcaagtct tagtgtagta attggtcttt cttttttagg aatttcatca   360
agcataagcc atataagttt tgcaatcatt ggtggcttag taagtgcaat ttttgtatac   420
gcgattgctg taagcggaaa agcaggcctt acccctataa aacttgcctt atcaggaact   480
tgtgttagta tggctttaag cagttttgta agttttttaa ttttaccgaa taataacgtc   540
ttagacaaat ttagattttg gcaaataggt agccttggag cagctacatt atcttctata   600
tctacactac taccttttat aattttaggt cacttgatag ctatatttat ttcatcagat   660
ttaaacgctt tagctatggg tgatgaaatg gctgttggtc ttggagttaa tgttaatagg   720
ataagatcac ttgcaataat tgcaagtgtg cttttatgtt caagtattac tgcaattggt   780
ggacctattg gcttcgtagg tcttatagtt cctcactttt gtggcttatt tataagcaaa   840
gatatacgca caatgaccat ttcttcatct tttataggtg cagagctctt gcttatatgt   900
gatataatcg gccgtatgtt aggtaaacca ggtgaaattg aagtagggat aattactgca   960
ataatcgggg gtccagtact tatttatgta actatgaaaa atagaggggt taataac      1017

<210>   2048
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron-compound ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902979 (0.E+01)

<400>   2048
Met His Ala Lys Met Arg Asn Lys Lys Gln Ile Asn Leu Gly Ile Ile 
1               5                   10                  15      

Phe Ile Ile Cys Leu Gly Leu Leu Ile Thr Ile Phe Leu Ser Leu Lys 
            20                  25                  30          

Leu Gly Thr Lys Glu Ile Asn Ile Arg Asp Phe Leu Ala Ala Phe Gly 
        35                  40                  45              

Met Gly Asn Thr Asn Asp Asp Phe Ile Lys Ser Ile Ile Tyr Lys Arg 
    50                  55                  60                  

Ile Pro Arg Thr Ile Phe Ala Ile Leu Ala Gly Ser Ser Leu Ala Ile 
65                  70                  75                  80  

Ser Gly Val Leu Met Gln Ser Val Thr Arg Asn Pro Ile Ala Asp Pro 
                85                  90                  95      

Gly Ile Leu Gly Ile Asn Thr Gly Ala Ser Leu Ser Val Val Ile Gly 
            100                 105                 110         

Leu Ser Phe Leu Gly Ile Ser Ser Ser Ile Ser His Ile Ser Phe Ala 
        115                 120                 125             

Ile Ile Gly Gly Leu Val Ser Ala Ile Phe Val Tyr Ala Ile Ala Val 
    130                 135                 140                 

Ser Gly Lys Ala Gly Leu Thr Pro Ile Lys Leu Ala Leu Ser Gly Thr 
145                 150                 155                 160 

Cys Val Ser Met Ala Leu Ser Ser Phe Val Ser Phe Leu Ile Leu Pro 
                165                 170                 175     

Asn Asn Asn Val Leu Asp Lys Phe Arg Phe Trp Gln Ile Gly Ser Leu 
            180                 185                 190         

Gly Ala Ala Thr Leu Ser Ser Ile Ser Thr Leu Leu Pro Phe Ile Ile 
        195                 200                 205             

Leu Gly His Leu Ile Ala Ile Phe Ile Ser Ser Asp Leu Asn Ala Leu 
    210                 215                 220                 

Ala Met Gly Asp Glu Met Ala Val Gly Leu Gly Val Asn Val Asn Arg 
225                 230                 235                 240 

Ile Arg Ser Leu Ala Ile Ile Ala Ser Val Leu Leu Cys Ser Ser Ile 
                245                 250                 255     

Thr Ala Ile Gly Gly Pro Ile Gly Phe Val Gly Leu Ile Val Pro His 
            260                 265                 270         

Phe Cys Gly Leu Phe Ile Ser Lys Asp Ile Arg Thr Met Thr Ile Ser 
        275                 280                 285             

Ser Ser Phe Ile Gly Ala Glu Leu Leu Leu Ile Cys Asp Ile Ile Gly 
    290                 295                 300                 

Arg Met Leu Gly Lys Pro Gly Glu Ile Glu Val Gly Ile Ile Thr Ala 
305                 310                 315                 320 

Ile Ile Gly Gly Pro Val Leu Ile Tyr Val Thr Met Lys Asn Arg Gly 
                325                 330                 335     

Val Asn Asn 
            

<210>   2049
<211>   411
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2049
atgtctgata acaaaactag taaaattcca accaatccag ctaatattgg gcttcttttc   60
ttgccaatat ttaaggctat gggaccagct aaaaaagata tacaagctat tggtcctgta   120
attgaagtag aaaaagcagt taaagataca gcgcaaaaaa ttaaaacaag ccttgaaagc   180
tcgggatttg ctccaagtcc gattgctatt tcttcaccaa gttcaataat ttctagtctt   240
ttattaaaaa ataaaactaa tatagtagca ataatactta ctattagaac aagaggtatg   300
tcatctaact ttgtaaaaga taaagagcca ctgagccatc tcataacttc ttgtaattca   360
tatcttgcta ctttcaacaa taaaaatgag gtgcctgctc ttgtgacagc t            411

<210>   2050
<211>   137
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2050
Met Ser Asp Asn Lys Thr Ser Lys Ile Pro Thr Asn Pro Ala Asn Ile 
1               5                   10                  15      

Gly Leu Leu Phe Leu Pro Ile Phe Lys Ala Met Gly Pro Ala Lys Lys 
            20                  25                  30          

Asp Ile Gln Ala Ile Gly Pro Val Ile Glu Val Glu Lys Ala Val Lys 
        35                  40                  45              

Asp Thr Ala Gln Lys Ile Lys Thr Ser Leu Glu Ser Ser Gly Phe Ala 
    50                  55                  60                  

Pro Ser Pro Ile Ala Ile Ser Ser Pro Ser Ser Ile Ile Ser Ser Leu 
65                  70                  75                  80  

Leu Leu Lys Asn Lys Thr Asn Ile Val Ala Ile Ile Leu Thr Ile Arg 
                85                  90                  95      

Thr Arg Gly Met Ser Ser Asn Phe Val Lys Asp Lys Glu Pro Leu Ser 
            100                 105                 110         

His Leu Ile Thr Ser Cys Asn Ser Tyr Leu Ala Thr Phe Asn Asn Lys 
        115                 120                 125             

Asn Glu Val Pro Ala Leu Val Thr Ala 
    130                 135         

<210>   2051
<211>   1005
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2051
atgcaaaatt taattatagg tattcaaaaa agaaaaaata gaataacact attttcctca   60
ctatttttat taataataat cagtctatca tttttcattt tacttatcgg agatgaaagt   120
tattcttttt caactttgat taaagtctta aatagtgaaa ctgttcctgg agctagtttt   180
tcgattatgg aaattagatt accaaaatta ttagcaggaa ttatagctgg ctggtctttt   240
ggattggcag gatttatctt tcaaactatg ttaagaaatc ctcttgcaag tcctgatata   300
atcggtgtca caagttcttc atctattgca gcggtctttt gcatattggt attaaaaaca   360
aatagtttaa ctactggaat tatttcaata acttgtggac taacatcatc tttaatatta   420
tttttactag ctaaaaaaga tggtttttca gcagcaagac tgataatatt aggtattggt   480
tttcaagctg tcacaagagc aggcacctca tttttattgt tgaaagtagc aagatatgaa   540
ttacaagaag ttatgagatg gctcagtggc tctttatctt ttacaaagtt agatgacata   600
cctcttgttc taatagtaag tattattgct actatattag ttttattttt taataaaaga   660
ctagaaatta ttgaacttgg tgaagaaata gcaatcggac ttggagcaaa tcccgagctt   720
tcaaggcttg ttttaatttt ttgcgctgta tctttaactg ctttttctac ttcaattaca   780
ggaccaatag cttgtatatc ttttttagct ggtcccatag ccttaaatat tggcaagaaa   840
agaagcccaa tattagctgg attggttgga attttactag ttttgttatc agacatattc   900
tctcaaaata ttttaccagc tagatatcca gtaggtgttg taactggctt gttaggttca   960
ccatacttaa tatacttact aataaaaatg aacaggagga atata                   1005

<210>   2052
<211>   335
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron-compound ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902980 (0.E+01)

<400>   2052
Met Gln Asn Leu Ile Ile Gly Ile Gln Lys Arg Lys Asn Arg Ile Thr 
1               5                   10                  15      

Leu Phe Ser Ser Leu Phe Leu Leu Ile Ile Ile Ser Leu Ser Phe Phe 
            20                  25                  30          

Ile Leu Leu Ile Gly Asp Glu Ser Tyr Ser Phe Ser Thr Leu Ile Lys 
        35                  40                  45              

Val Leu Asn Ser Glu Thr Val Pro Gly Ala Ser Phe Ser Ile Met Glu 
    50                  55                  60                  

Ile Arg Leu Pro Lys Leu Leu Ala Gly Ile Ile Ala Gly Trp Ser Phe 
65                  70                  75                  80  

Gly Leu Ala Gly Phe Ile Phe Gln Thr Met Leu Arg Asn Pro Leu Ala 
                85                  90                  95      

Ser Pro Asp Ile Ile Gly Val Thr Ser Ser Ser Ser Ile Ala Ala Val 
            100                 105                 110         

Phe Cys Ile Leu Val Leu Lys Thr Asn Ser Leu Thr Thr Gly Ile Ile 
        115                 120                 125             

Ser Ile Thr Cys Gly Leu Thr Ser Ser Leu Ile Leu Phe Leu Leu Ala 
    130                 135                 140                 

Lys Lys Asp Gly Phe Ser Ala Ala Arg Leu Ile Ile Leu Gly Ile Gly 
145                 150                 155                 160 

Phe Gln Ala Val Thr Arg Ala Gly Thr Ser Phe Leu Leu Leu Lys Val 
                165                 170                 175     

Ala Arg Tyr Glu Leu Gln Glu Val Met Arg Trp Leu Ser Gly Ser Leu 
            180                 185                 190         

Ser Phe Thr Lys Leu Asp Asp Ile Pro Leu Val Leu Ile Val Ser Ile 
        195                 200                 205             

Ile Ala Thr Ile Leu Val Leu Phe Phe Asn Lys Arg Leu Glu Ile Ile 
    210                 215                 220                 

Glu Leu Gly Glu Glu Ile Ala Ile Gly Leu Gly Ala Asn Pro Glu Leu 
225                 230                 235                 240 

Ser Arg Leu Val Leu Ile Phe Cys Ala Val Ser Leu Thr Ala Phe Ser 
                245                 250                 255     

Thr Ser Ile Thr Gly Pro Ile Ala Cys Ile Ser Phe Leu Ala Gly Pro 
            260                 265                 270         

Ile Ala Leu Asn Ile Gly Lys Lys Arg Ser Pro Ile Leu Ala Gly Leu 
        275                 280                 285             

Val Gly Ile Leu Leu Val Leu Leu Ser Asp Ile Phe Ser Gln Asn Ile 
    290                 295                 300                 

Leu Pro Ala Arg Tyr Pro Val Gly Val Val Thr Gly Leu Leu Gly Ser 
305                 310                 315                 320 

Pro Tyr Leu Ile Tyr Leu Leu Ile Lys Met Asn Arg Arg Asn Ile 
                325                 330                 335 

<210>   2053
<211>   792
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2053
atgaaaggtc tgtggtcaaa taatcttacc tgcggttatg atgaaaaaat aatcttggaa   60
aatataaata taaaaatacc tgaagaaaaa atatcagtta ttattgggtc aaatggttgt   120
gggaaatcaa cactcattaa aaccttgtct cgacttataa agccattaga gggagaagta   180
ttgcttgata ataaatcaat taattcttat aaagaaaaag atttagcaaa acacatagct   240
atattacctc aatctccaat aatccctgaa tcaataacag tagctgatct tgtaagccgt   300
ggtcgtttcc cctacagaaa gccttttaag agtcttggaa aagatgacct tgaaataata   360
aacagatcaa tggttaaggc caatgttgaa gatctagcaa ataacctagt tgaagaactt   420
tctgggggtc aaaggcaaag agtatggata gctctagccc tagcccaaga tacaagtatc   480
ctacttttag atgagccaac tacttacttg gatatctcat atcaaataga actattagac   540
ctcttgactg atctaaacca aaaatataag acaaccattt gcatgatttt gcacgatata   600
aatctaacag caagatacgc tgattaccta tttgcaatta aagaaggtaa acttgttgca   660
gagggaaagc ctgaagatat actaaatgat aaactagtta aagatatctt taatcttgaa   720
gcaaaaatta tacgtgaccc tatttccaat tcgcctctaa tgattcctat tggcaagcac   780
catgttaact ct                                                       792

<210>   2054
<211>   264
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron-compound ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902982 (e-149)

<400>   2054
Met Lys Gly Leu Trp Ser Asn Asn Leu Thr Cys Gly Tyr Asp Glu Lys 
1               5                   10                  15      

Ile Ile Leu Glu Asn Ile Asn Ile Lys Ile Pro Glu Glu Lys Ile Ser 
            20                  25                  30          

Val Ile Ile Gly Ser Asn Gly Cys Gly Lys Ser Thr Leu Ile Lys Thr 
        35                  40                  45              

Leu Ser Arg Leu Ile Lys Pro Leu Glu Gly Glu Val Leu Leu Asp Asn 
    50                  55                  60                  

Lys Ser Ile Asn Ser Tyr Lys Glu Lys Asp Leu Ala Lys His Ile Ala 
65                  70                  75                  80  

Ile Leu Pro Gln Ser Pro Ile Ile Pro Glu Ser Ile Thr Val Ala Asp 
                85                  90                  95      

Leu Val Ser Arg Gly Arg Phe Pro Tyr Arg Lys Pro Phe Lys Ser Leu 
            100                 105                 110         

Gly Lys Asp Asp Leu Glu Ile Ile Asn Arg Ser Met Val Lys Ala Asn 
        115                 120                 125             

Val Glu Asp Leu Ala Asn Asn Leu Val Glu Glu Leu Ser Gly Gly Gln 
    130                 135                 140                 

Arg Gln Arg Val Trp Ile Ala Leu Ala Leu Ala Gln Asp Thr Ser Ile 
145                 150                 155                 160 

Leu Leu Leu Asp Glu Pro Thr Thr Tyr Leu Asp Ile Ser Tyr Gln Ile 
                165                 170                 175     

Glu Leu Leu Asp Leu Leu Thr Asp Leu Asn Gln Lys Tyr Lys Thr Thr 
            180                 185                 190         

Ile Cys Met Ile Leu His Asp Ile Asn Leu Thr Ala Arg Tyr Ala Asp 
        195                 200                 205             

Tyr Leu Phe Ala Ile Lys Glu Gly Lys Leu Val Ala Glu Gly Lys Pro 
    210                 215                 220                 

Glu Asp Ile Leu Asn Asp Lys Leu Val Lys Asp Ile Phe Asn Leu Glu 
225                 230                 235                 240 

Ala Lys Ile Ile Arg Asp Pro Ile Ser Asn Ser Pro Leu Met Ile Pro 
                245                 250                 255     

Ile Gly Lys His His Val Asn Ser 
            260                 

<210>   2055
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2055
ttgtttatta tcagtcctga tctttttaat attgctgtta ttctctatat cctatttttc   60
attcatgata ttcttttact aattttatct                                    90

<210>   2056
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   2056
Met Phe Ile Ile Ser Pro Asp Leu Phe Asn Ile Ala Val Ile Leu Tyr 
1               5                   10                  15      

Ile Leu Phe Phe Ile His Asp Ile Leu Leu Leu Ile Leu Ser 
            20                  25                  30  

<210>   2057
<211>   207
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2057
atgaaaattc attgtttaaa attaaaaaat aaagaattga ataaagaagt agcattctat   60
ttaacttcaa ttattaggca agctttaaaa aatactgaat ataaagatca aatatctagc   120
acagtattgc cagatatcaa aattaaatta ccgatagaca gtagaggtac tccagattgg   180
aattacatgg aaagatatag agataga                                       207

<210>   2058
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type II restriction endonuclease, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902983 (1.E-36)

<400>   2058
Met Lys Ile His Cys Leu Lys Leu Lys Asn Lys Glu Leu Asn Lys Glu 
1               5                   10                  15      

Val Ala Phe Tyr Leu Thr Ser Ile Ile Arg Gln Ala Leu Lys Asn Thr 
            20                  25                  30          

Glu Tyr Lys Asp Gln Ile Ser Ser Thr Val Leu Pro Asp Ile Lys Ile 
        35                  40                  45              

Lys Leu Pro Ile Asp Ser Arg Gly Thr Pro Asp Trp Asn Tyr Met Glu 
    50                  55                  60                  

Arg Tyr Arg Asp Arg 
65                  

<210>   2059
<211>   153
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2059
atgataaata aactatccag atacatggaa agcagtggta agacctatca aaaccactat   60
gtgacaatct taaaatggta tgaagaagat aaagacaaac taagacagaa aggtttaaat   120
aaaaaaatga attatgatgt aggagaatct tta                                153

<210>   2060
<211>   51
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902984 (2.E-26)

<400>   2060
Met Ile Asn Lys Leu Ser Arg Tyr Met Glu Ser Ser Gly Lys Thr Tyr 
1               5                   10                  15      

Gln Asn His Tyr Val Thr Ile Leu Lys Trp Tyr Glu Glu Asp Lys Asp 
            20                  25                  30          

Lys Leu Arg Gln Lys Gly Leu Asn Lys Lys Met Asn Tyr Asp Val Gly 
        35                  40                  45              

Glu Ser Leu 
    50      

<210>   2061
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2061
ttggacaatg actggaatgg attggctgat ttaatagcaa atctgattgc aaaatatgct   60
ggtgctttag atttagataa tctacccgat ccaacgccag caaaaaatca agagatgaaa   120
aatagttttg acatggcaaa aacacaaatt gagacggac                          159

<210>   2062
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902985 (2.E-27)

<400>   2062
Met Asp Asn Asp Trp Asn Gly Leu Ala Asp Leu Ile Ala Asn Leu Ile 
1               5                   10                  15      

Ala Lys Tyr Ala Gly Ala Leu Asp Leu Asp Asn Leu Pro Asp Pro Thr 
            20                  25                  30          

Pro Ala Lys Asn Gln Glu Met Lys Asn Ser Phe Asp Met Ala Lys Thr 
        35                  40                  45              

Gln Ile Glu Thr Asp 
    50              

<210>   2063
<211>   1677
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2063
atgtcaaaag aaaaaataaa agtatacctc tatacacgag tatctacgtc aatacagata   60
gaggggtatt cgttagaggc acaaaaatca cgaatgaaag cttttgctat ttacaacgat   120
tatgaaattg ttggagagta tgaagatgcc gggaagtctg acaagtctat tgaaggtaga   180
atacagttca atcgaatgat ggaagatata aaatctggaa aagatggagt atcttttgtt   240
cttgtgttta agttatcaag atttgcaaga aatgccgctg atgttctttc tacacttcat   300
ataatgcagg attatggagt taatcttatc tgcgttgaag atggcattga ttcatctaaa   360
gatgctggga aactaatgat ttctgtttta tcagctgtgg ctgaaataga aagagaaaac   420
atcagtattc aaacaatgga aggtcgcatt caaaaagcag gggaaggaaa atggaatggt   480
ggctttgctc cgtatggata taaacttgaa gacggcaagc tgtttataaa tgaggaagag   540
gcagttgcaa taagaacgat tttcgaccag tatgtaaata ctacgatagg agccaatggg   600
atatctaaat acttagagaa tcatggaatt agaaaaatcc caagacagaa tggtaagaat   660
cctttgtttg atgcaggtct tataagaaag atattaaaga atcctgtata taatgggaaa   720
atagcatttg gaagaagaac tttagaaaaa gttcatggta caagaaatga atataagcag   780
gttgaacaag atgaatatct aatatctgaa gggatacatg aagctatagt ttccgatgaa   840
gtttggcaag ctgctcaggt taagctaaaa tctcaagcaa agaaatatga gcatgtgaat   900
aaaggaaaag atacacgcac acacttgctt tctggaattg taaaatgccc gatatgtgga   960
gtgggaatgt ttgggaacaa gtgtatcaag aaaaagaaag atggcacaaa gtataaagat   1020
ttttattact atggttgtaa ccataggcag atgataagag gtaataagtg tacattcagt   1080
aagcaaatta gagaagaatt gttagatgat gctgttgcag aggtgattgt caagatagta   1140
agtaatccga aatttgcttc tatgatgcaa gaaaaaatca acatgaaggt ggatacctct   1200
gaaatagaaa aagaaataga taattaccaa aaggaattga gaaagagtca ttctacaaag   1260
tttaagctaa ttgaggaaat agataattta gatgttgaag ataagcatta taagagaagg   1320
aaacaggatt tagatgatag actatatcgt atgtatgaca aactagatga attagaatca   1380
tcactaattg atgcgaaagc aaagaaacag actattgaag ctgaaaagct tacaggagat   1440
aacatatata aggttctgat ctattttgat aagctctata aagtcatgaa tgatgtagag   1500
cgtaggcagt taatttcagc tttgatttct gaaattcaag tttatgaaga aaaacaatct   1560
aacggacaat ggctaaaatc cattactttt aagctaccaa ttatagaaga aaatctcaac   1620
ataggtttgg acaatgatga acaagttgaa tgtgtaagtt tattagagaa acgtagt      1677

<210>   2064
<211>   559
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   site-specific recombinase, resolvase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902986 (0.E+01)

<400>   2064
Met Ser Lys Glu Lys Ile Lys Val Tyr Leu Tyr Thr Arg Val Ser Thr 
1               5                   10                  15      

Ser Ile Gln Ile Glu Gly Tyr Ser Leu Glu Ala Gln Lys Ser Arg Met 
            20                  25                  30          

Lys Ala Phe Ala Ile Tyr Asn Asp Tyr Glu Ile Val Gly Glu Tyr Glu 
        35                  40                  45              

Asp Ala Gly Lys Ser Asp Lys Ser Ile Glu Gly Arg Ile Gln Phe Asn 
    50                  55                  60                  

Arg Met Met Glu Asp Ile Lys Ser Gly Lys Asp Gly Val Ser Phe Val 
65                  70                  75                  80  

Leu Val Phe Lys Leu Ser Arg Phe Ala Arg Asn Ala Ala Asp Val Leu 
                85                  90                  95      

Ser Thr Leu His Ile Met Gln Asp Tyr Gly Val Asn Leu Ile Cys Val 
            100                 105                 110         

Glu Asp Gly Ile Asp Ser Ser Lys Asp Ala Gly Lys Leu Met Ile Ser 
        115                 120                 125             

Val Leu Ser Ala Val Ala Glu Ile Glu Arg Glu Asn Ile Ser Ile Gln 
    130                 135                 140                 

Thr Met Glu Gly Arg Ile Gln Lys Ala Gly Glu Gly Lys Trp Asn Gly 
145                 150                 155                 160 

Gly Phe Ala Pro Tyr Gly Tyr Lys Leu Glu Asp Gly Lys Leu Phe Ile 
                165                 170                 175     

Asn Glu Glu Glu Ala Val Ala Ile Arg Thr Ile Phe Asp Gln Tyr Val 
            180                 185                 190         

Asn Thr Thr Ile Gly Ala Asn Gly Ile Ser Lys Tyr Leu Glu Asn His 
        195                 200                 205             

Gly Ile Arg Lys Ile Pro Arg Gln Asn Gly Lys Asn Pro Leu Phe Asp 
    210                 215                 220                 

Ala Gly Leu Ile Arg Lys Ile Leu Lys Asn Pro Val Tyr Asn Gly Lys 
225                 230                 235                 240 

Ile Ala Phe Gly Arg Arg Thr Leu Glu Lys Val His Gly Thr Arg Asn 
                245                 250                 255     

Glu Tyr Lys Gln Val Glu Gln Asp Glu Tyr Leu Ile Ser Glu Gly Ile 
            260                 265                 270         

His Glu Ala Ile Val Ser Asp Glu Val Trp Gln Ala Ala Gln Val Lys 
        275                 280                 285             

Leu Lys Ser Gln Ala Lys Lys Tyr Glu His Val Asn Lys Gly Lys Asp 
    290                 295                 300                 

Thr Arg Thr His Leu Leu Ser Gly Ile Val Lys Cys Pro Ile Cys Gly 
305                 310                 315                 320 

Val Gly Met Phe Gly Asn Lys Cys Ile Lys Lys Lys Lys Asp Gly Thr 
                325                 330                 335     

Lys Tyr Lys Asp Phe Tyr Tyr Tyr Gly Cys Asn His Arg Gln Met Ile 
            340                 345                 350         

Arg Gly Asn Lys Cys Thr Phe Ser Lys Gln Ile Arg Glu Glu Leu Leu 
        355                 360                 365             

Asp Asp Ala Val Ala Glu Val Ile Val Lys Ile Val Ser Asn Pro Lys 
    370                 375                 380                 

Phe Ala Ser Met Met Gln Glu Lys Ile Asn Met Lys Val Asp Thr Ser 
385                 390                 395                 400 

Glu Ile Glu Lys Glu Ile Asp Asn Tyr Gln Lys Glu Leu Arg Lys Ser 
                405                 410                 415     

His Ser Thr Lys Phe Lys Leu Ile Glu Glu Ile Asp Asn Leu Asp Val 
            420                 425                 430         

Glu Asp Lys His Tyr Lys Arg Arg Lys Gln Asp Leu Asp Asp Arg Leu 
        435                 440                 445             

Tyr Arg Met Tyr Asp Lys Leu Asp Glu Leu Glu Ser Ser Leu Ile Asp 
    450                 455                 460                 

Ala Lys Ala Lys Lys Gln Thr Ile Glu Ala Glu Lys Leu Thr Gly Asp 
465                 470                 475                 480 

Asn Ile Tyr Lys Val Leu Ile Tyr Phe Asp Lys Leu Tyr Lys Val Met 
                485                 490                 495     

Asn Asp Val Glu Arg Arg Gln Leu Ile Ser Ala Leu Ile Ser Glu Ile 
            500                 505                 510         

Gln Val Tyr Glu Glu Lys Gln Ser Asn Gly Gln Trp Leu Lys Ser Ile 
        515                 520                 525             

Thr Phe Lys Leu Pro Ile Ile Glu Glu Asn Leu Asn Ile Gly Leu Asp 
    530                 535                 540                 

Asn Asp Glu Gln Val Glu Cys Val Ser Leu Leu Glu Lys Arg Ser 
545                 550                 555                 

<210>   2065
<211>   609
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2065
gtgcttattt acattagcct gataatgaaa atggagagat tatcgatggt tatattggaa   60
ttgtaccaaa atgattattc taaagattta gtagcatttg attccataga agatgggaaa   120
gcctttgtag ctcaaatccc gggatacact ctggaaacag aagatggttt tgaagtggag   180
tattttaatc ctaaaaacat accggattat atggaaatta tttttaacgg aaatattgtt   240
cctttatcta aatttatgtt cgatcctgag gaaaatgtaa acattatttg gaaagagatt   300
tcaaatttat ccctcaaaaa tgatagagtg atcgaaggat attcaaaaat tgatgcatat   360
gtcgttaaca accatgaagt taaagcctat gtcgaaacaa gagaaacgaa ctatcgtaaa   420
gcaaaagact tcttagaaag ccgcggatat gaaatcgaca gaagcttttt cggaagtgaa   480
gacggtgaag cgattcttta cagaaaaaaa gggatcgaag tttggcattt cttgtgtcac   540
ttagacccaa tgtttgtaga gattgaagat gtagaaggat atgttaaaga agaagttgga   600
gagattcaa                                                           609

<210>   2066
<211>   203
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902987 (e-116)

<400>   2066
Met Leu Ile Tyr Ile Ser Leu Ile Met Lys Met Glu Arg Leu Ser Met 
1               5                   10                  15      

Val Ile Leu Glu Leu Tyr Gln Asn Asp Tyr Ser Lys Asp Leu Val Ala 
            20                  25                  30          

Phe Asp Ser Ile Glu Asp Gly Lys Ala Phe Val Ala Gln Ile Pro Gly 
        35                  40                  45              

Tyr Thr Leu Glu Thr Glu Asp Gly Phe Glu Val Glu Tyr Phe Asn Pro 
    50                  55                  60                  

Lys Asn Ile Pro Asp Tyr Met Glu Ile Ile Phe Asn Gly Asn Ile Val 
65                  70                  75                  80  

Pro Leu Ser Lys Phe Met Phe Asp Pro Glu Glu Asn Val Asn Ile Ile 
                85                  90                  95      

Trp Lys Glu Ile Ser Asn Leu Ser Leu Lys Asn Asp Arg Val Ile Glu 
            100                 105                 110         

Gly Tyr Ser Lys Ile Asp Ala Tyr Val Val Asn Asn His Glu Val Lys 
        115                 120                 125             

Ala Tyr Val Glu Thr Arg Glu Thr Asn Tyr Arg Lys Ala Lys Asp Phe 
    130                 135                 140                 

Leu Glu Ser Arg Gly Tyr Glu Ile Asp Arg Ser Phe Phe Gly Ser Glu 
145                 150                 155                 160 

Asp Gly Glu Ala Ile Leu Tyr Arg Lys Lys Gly Ile Glu Val Trp His 
                165                 170                 175     

Phe Leu Cys His Leu Asp Pro Met Phe Val Glu Ile Glu Asp Val Glu 
            180                 185                 190         

Gly Tyr Val Lys Glu Glu Val Gly Glu Ile Gln 
        195                 200             

<210>   2067
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2067
gtgatgaaaa tggcaaccga taaaaataga ataatgatta gcttggatga taaaaatcta   60
gagaaacttg aaaatttagt agaagatgct agagatagaa ggggaatgcg actaacaaag   120
tcccaggtta ttgaattact cctaaatacc gttgattatt tcgatgatat tatgggggct   180
atttactcaa aaaaa                                                    195

<210>   2068
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902988 (7.E-32)

<400>   2068
Met Met Lys Met Ala Thr Asp Lys Asn Arg Ile Met Ile Ser Leu Asp 
1               5                   10                  15      

Asp Lys Asn Leu Glu Lys Leu Glu Asn Leu Val Glu Asp Ala Arg Asp 
            20                  25                  30          

Arg Arg Gly Met Arg Leu Thr Lys Ser Gln Val Ile Glu Leu Leu Leu 
        35                  40                  45              

Asn Thr Val Asp Tyr Phe Asp Asp Ile Met Gly Ala Ile Tyr Ser Lys 
    50                  55                  60                  

Lys 
65  

<210>   2069
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2069
atggttgttt atattagaca aagtaaatta ccaagtgagg tttcaattaa taaatacaat   60
gctcaagtag gtgcctactt acaaggagaa gaagttattt tatatcaatc tttttctgaa   120
ataaaagagt taacaagtga agatatagtt gtagattata taatggagac tagagcatta   180
ctaaaaatga tgggcttaaa cgttccggtt catgactatc ctattgagct taaagagttt   240
tatggtcgaa agatttatgc tggtatttta ggagagattg tgaatatacc tgataattgg   300
ggaaaattta ttaagcctaa agctggttca aaagtcttta ctggaagagt tgttaatgga   360
acccatgatt taataggtat tggtctacct ttcgactatc ctatatggat tagtgaggtt   420
gtagaattca tagctgaatg gcgttgtttt gtgttagatg gtcgcgtatt agatgttcga   480
ccctatacag gtgattatca tgcacaattt gatgcaagtg taattgatga agcgatatca   540
tgttggaaag atgcgccaat agcttatgga ctagatatcg gtgttactcg cgatggcaga   600
acacttgttg ttgaagtaaa tgatggttat gcattgggaa attatggcct atctccttta   660
aaatcaatca attttcatag agctaggtgg aaagaaatgg taaaacccta ttttgaaaaa   720
aatgaaattt ttaaaatcca acaggatgtt attttc                             756

<210>   2070
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902989 (e-138)

<400>   2070
Met Val Val Tyr Ile Arg Gln Ser Lys Leu Pro Ser Glu Val Ser Ile 
1               5                   10                  15      


Asn Lys Tyr Asn Ala Gln Val Gly Ala Tyr Leu Gln Gly Glu Glu Val 
            20                  25                  30          

Ile Leu Tyr Gln Ser Phe Ser Glu Ile Lys Glu Leu Thr Ser Glu Asp 
        35                  40                  45              

Ile Val Val Asp Tyr Ile Met Glu Thr Arg Ala Leu Leu Lys Met Met 
    50                  55                  60                  

Gly Leu Asn Val Pro Val His Asp Tyr Pro Ile Glu Leu Lys Glu Phe 
65                  70                  75                  80  

Tyr Gly Arg Lys Ile Tyr Ala Gly Ile Leu Gly Glu Ile Val Asn Ile 
                85                  90                  95      

Pro Asp Asn Trp Gly Lys Phe Ile Lys Pro Lys Ala Gly Ser Lys Val 
            100                 105                 110         

Phe Thr Gly Arg Val Val Asn Gly Thr His Asp Leu Ile Gly Ile Gly 
        115                 120                 125             

Leu Pro Phe Asp Tyr Pro Ile Trp Ile Ser Glu Val Val Glu Phe Ile 
    130                 135                 140                 

Ala Glu Trp Arg Cys Phe Val Leu Asp Gly Arg Val Leu Asp Val Arg 
145                 150                 155                 160 

Pro Tyr Thr Gly Asp Tyr His Ala Gln Phe Asp Ala Ser Val Ile Asp 
                165                 170                 175     

Glu Ala Ile Ser Cys Trp Lys Asp Ala Pro Ile Ala Tyr Gly Leu Asp 
            180                 185                 190         

Ile Gly Val Thr Arg Asp Gly Arg Thr Leu Val Val Glu Val Asn Asp 
        195                 200                 205             

Gly Tyr Ala Leu Gly Asn Tyr Gly Leu Ser Pro Leu Lys Ser Ile Asn 
    210                 215                 220                 

Phe His Arg Ala Arg Trp Lys Glu Met Val Lys Pro Tyr Phe Glu Lys 
225                 230                 235                 240 

Asn Glu Ile Phe Lys Ile Gln Gln Asp Val Ile Phe 
                245                 250         

<210>   2071
<211>   852
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2071
atgcttggag caattattgg agatattgtc ggttctgttt acgaatggaa caatatcaaa   60
acaaaggact ttcctttatt tcggaaggac tgctttttta cagatgacac ggttatgacc   120
tgtgctgttg cagaagcaat tatgaatggt ggacaaaaag atgacttcat tgacgcgatg   180
aagaaatatg gcagaatgta tccgaatgct gattacggtg ctcggtttaa tgcatggcta   240
aacagcgata accgtgagcc ttataatagc tttgggaatg gatcagctat gcgtatttct   300
ccatgtgctt ggatcatgga ctgtggtttt tatgcgaaaa ctggtatatg gccatcatct   360
agaggactta cgagtctttc tgcagaggta actcataatc atccagaagg tgtcaaaggc   420
gctatggcta cagctgatgc tatctttcta tgtcgttttt actttggtgg ttattgtaga   480
gagtacgagc aatcaattaa cgacaatcct acagagtgta aaagacgaat taaggattat   540
atagaaaaag aatacgatta caatctatct caaactttag atgaaatccg tcctaactat   600
cgttttaacg aaacatgtca ggaaactgtc cctcaagcca ttatcgcctt tcttgaaagt   660
agagacttcg aagatgcgat aagaaatgcc atctcacttg gtggcgacag tgatactctc   720
gcagcaatca cttgtagcat agcagaggca gcttacggta ttcctgattg gatcaaggat   780
aaggcctatt cttacttgga tgaaccctta aaggatgtag ttaggcgatg ggaaaataga   840
ataaaagcgt at                                                       852

<210>   2072
<211>   284
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydrolase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902990 (e-172)

<400>   2072
Met Leu Gly Ala Ile Ile Gly Asp Ile Val Gly Ser Val Tyr Glu Trp 
1               5                   10                  15      

Asn Asn Ile Lys Thr Lys Asp Phe Pro Leu Phe Arg Lys Asp Cys Phe 
            20                  25                  30          

Phe Thr Asp Asp Thr Val Met Thr Cys Ala Val Ala Glu Ala Ile Met 
        35                  40                  45              

Asn Gly Gly Gln Lys Asp Asp Phe Ile Asp Ala Met Lys Lys Tyr Gly 
    50                  55                  60                  

Arg Met Tyr Pro Asn Ala Asp Tyr Gly Ala Arg Phe Asn Ala Trp Leu 
65                  70                  75                  80  

Asn Ser Asp Asn Arg Glu Pro Tyr Asn Ser Phe Gly Asn Gly Ser Ala 
                85                  90                  95      


Met Arg Ile Ser Pro Cys Ala Trp Ile Met Asp Cys Gly Phe Tyr Ala 
            100                 105                 110         

Lys Thr Gly Ile Trp Pro Ser Ser Arg Gly Leu Thr Ser Leu Ser Ala 
        115                 120                 125             

Glu Val Thr His Asn His Pro Glu Gly Val Lys Gly Ala Met Ala Thr 
    130                 135                 140                 

Ala Asp Ala Ile Phe Leu Cys Arg Phe Tyr Phe Gly Gly Tyr Cys Arg 
145                 150                 155                 160 

Glu Tyr Glu Gln Ser Ile Asn Asp Asn Pro Thr Glu Cys Lys Arg Arg 
                165                 170                 175     

Ile Lys Asp Tyr Ile Glu Lys Glu Tyr Asp Tyr Asn Leu Ser Gln Thr 
            180                 185                 190         

Leu Asp Glu Ile Arg Pro Asn Tyr Arg Phe Asn Glu Thr Cys Gln Glu 
        195                 200                 205             

Thr Val Pro Gln Ala Ile Ile Ala Phe Leu Glu Ser Arg Asp Phe Glu 
    210                 215                 220                 

Asp Ala Ile Arg Asn Ala Ile Ser Leu Gly Gly Asp Ser Asp Thr Leu 
225                 230                 235                 240 

Ala Ala Ile Thr Cys Ser Ile Ala Glu Ala Ala Tyr Gly Ile Pro Asp 
                245                 250                 255     

Trp Ile Lys Asp Lys Ala Tyr Ser Tyr Leu Asp Glu Pro Leu Lys Asp 
            260                 265                 270         

Val Val Arg Arg Trp Glu Asn Arg Ile Lys Ala Tyr 
        275                 280                 

<210>   2073
<211>   882
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2073
atgaaaaaag caatggtaat tatcaaccct acttctggtg gcgagaaggc tttggattac   60
aaagaaaagc tggagaataa agcaaaagaa tactttgaat atgttgaaac caaaattacc   120
gaaaaagcgc tggatgcaac acattttgct gaagaagctt ctcgtgagca gtatgatgca   180
gtggttgtgt ttggtggaga tggaactgtc aatgaagtca tttcaggtat tgatgagaga   240
gactacattc ctaagttagg gattatccca ggcggtacgg gtaacctcat tacaaaactt   300
ttggaaatca atcaagacat cgatggcgca attgacgaac tggattttga tttaaccaat   360
aagattgata tcggtaaagc aaatgacaac tattttggtt atatctttag tatcggttct   420
ctgcctgagg cgattcacaa tgttgaaata gaggacaaaa caaaattcgg tattttaacc   480
tatgctgtaa ataccatgaa gtctgtcatg acagatcagg tctttaacat taaggttgag   540
acagaaaatg gaaattatgt tggtgaagct agccatgttt tggtcctttt gacaaattac   600
ttcgctgata agaaaatctt tgaagaaaac aaggacggct atgccaacat tttgattctg   660
aaagatgcct ctatattctc caaattatcc gtcattcctg atttattaaa aggggatgtt   720
gtcgcaaatg ataatatcga gtatatcaaa gcgcgtaata ttaaaatctc ttcagatagt   780
gaattggagt cagatgttga cggagataaa tcagataacc tacctgtaga aatcaaagtc   840
ctagctcagc gagtagaagt attttcaaaa ccgaaagagg at                      882

<210>   2074
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein TIGR00147
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902991 (e-166)

<400>   2074
Met Lys Lys Ala Met Val Ile Ile Asn Pro Thr Ser Gly Gly Glu Lys 
1               5                   10                  15      

Ala Leu Asp Tyr Lys Glu Lys Leu Glu Asn Lys Ala Lys Glu Tyr Phe 
            20                  25                  30          

Glu Tyr Val Glu Thr Lys Ile Thr Glu Lys Ala Leu Asp Ala Thr His 
        35                  40                  45              

Phe Ala Glu Glu Ala Ser Arg Glu Gln Tyr Asp Ala Val Val Val Phe 
    50                  55                  60                  

Gly Gly Asp Gly Thr Val Asn Glu Val Ile Ser Gly Ile Asp Glu Arg 
65                  70                  75                  80  

Asp Tyr Ile Pro Lys Leu Gly Ile Ile Pro Gly Gly Thr Gly Asn Leu 
                85                  90                  95      

Ile Thr Lys Leu Leu Glu Ile Asn Gln Asp Ile Asp Gly Ala Ile Asp 
            100                 105                 110         

Glu Leu Asp Phe Asp Leu Thr Asn Lys Ile Asp Ile Gly Lys Ala Asn 
        115                 120                 125             

Asp Asn Tyr Phe Gly Tyr Ile Phe Ser Ile Gly Ser Leu Pro Glu Ala 
    130                 135                 140                 

Ile His Asn Val Glu Ile Glu Asp Lys Thr Lys Phe Gly Ile Leu Thr 
145                 150                 155                 160 

Tyr Ala Val Asn Thr Met Lys Ser Val Met Thr Asp Gln Val Phe Asn 
                165                 170                 175     

Ile Lys Val Glu Thr Glu Asn Gly Asn Tyr Val Gly Glu Ala Ser His 
            180                 185                 190         

Val Leu Val Leu Leu Thr Asn Tyr Phe Ala Asp Lys Lys Ile Phe Glu 
        195                 200                 205             

Glu Asn Lys Asp Gly Tyr Ala Asn Ile Leu Ile Leu Lys Asp Ala Ser 
    210                 215                 220                 

Ile Phe Ser Lys Leu Ser Val Ile Pro Asp Leu Leu Lys Gly Asp Val 
225                 230                 235                 240 

Val Ala Asn Asp Asn Ile Glu Tyr Ile Lys Ala Arg Asn Ile Lys Ile 
                245                 250                 255     

Ser Ser Asp Ser Glu Leu Glu Ser Asp Val Asp Gly Asp Lys Ser Asp 
            260                 265                 270         

Asn Leu Pro Val Glu Ile Lys Val Leu Ala Gln Arg Val Glu Val Phe 
        275                 280                 285             

Ser Lys Pro Lys Glu Asp 
    290                 

<210>   2075
<211>   1761
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2075
atgaatactt taggagacaa attgatggaa ttgagtgcta tttaccatag gcctgagtcg   60
gagtatgact atctttataa ggataagaaa ctccatattc gaattcgaac taagaaaggg   120
gacattgaaa gcatcaactt gcactatggg gaccctttta tctttatgga ggagttttat   180
caggatacaa aagaaatggt caagataact tctggtacct tatttgacca ttggcaggtt   240
gaagtgtcag ttgactttgc acgtatccag tatctctttg agctcagaga tacagaaggt   300
caaaatattt tgtatggcga taaagggtgt gtggaaaatt ctctagaaaa tcttcatgca   360
attgggaatg gatttaagtt gccttagctt catgagattg atgcctgcaa ggttcctgac   420
tgggtttcaa atacggtatg gtatcagata tttcctgaaa gatttgccaa tggcaatgct   480
ctattaaacc cagaagggac tttagactgg gattcatctg tcacacctaa gagcgatgat   540
ttctttggtg gtgatttaca ggggattatt gatcatatga attacttgca agacttgggt   600
attactggac tatatctttg tcccatcttt gaatctacaa gcaatcacaa gtacaatacg   660
acagattact ttgaaattga ccgtcatttt ggagacaagg agacctttcg ggaactggtg   720
gatcaagcgc atcatcgtgg catgaaagtc atgctggatg cggtatttaa tcatattggt   780
tcgcaatctc ttcaatggaa aaatgtcgtc aaaaatggtg aacagtctgc ttataaggat   840
tggttccata ttcaacaatt cccagtgaca actgaaaagc tagttaataa gagagactta   900
ccctatcatg tttttggttt cgaggactat atgcctaagc taaatacagc caatccagag   960
gtcaagaatt atcttttaaa ggttgcgact tattggattg aagagtttaa tatcgatgct   1020
tggcgtttgg atgtggctaa tgagattgac catcagttct ggaaggattt tcgtaaggca   1080
gttttagcta aaaatcctga tctttatatc ctaggagaag tctggcatac atctcagcct   1140
tggctaaatg gagatgagtt ccatgccgtc atgaattatc ctttatctga tagtatcaag   1200
gactatttct tacgaggaat taagaagaca gaccagttca tcgatgaaat caatggagag   1260
tctatgtatt acaagcagca gatttcagag gtcatgttta atctcttgga ttcacatgat   1320
acagagcgaa tcctgtggac ggccaatgaa gatgttcaac tggttaaatc agccttagcc   1380
tttctctttt tacaaaaagg aacaccgtgc atttattacg gaaccgagct agccttgact   1440
ggaggaccag atccagattg tcgtcgttgt atgccttggg aacgtgtatc aagtgacaat   1500
gatatgctga actttatgaa gaggctgatt aaaattcgga aatacgcgtc agtaatcatt   1560
tcgcatggca agtatagcct tcaagaaatc aactctgatc tagtagctct ggaatggaaa   1620
tacgaaggac ggatcctcaa agcaatattc aaccaatcaa cagaagatta tcttttagag   1680
aaagaagcag tagcactagc aagcaattgc caagaattgg ataatcagct tgtcatctct   1740
ccagatggat ttatgatttt c                                             1761


<210>   2076
<400>   2076
000

<210>   2077
<211>   315
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2077
atgaattgta gaggacatga aacaagacaa agaattgtta gagattttga agttcagcct   60
aaagcacata ttaagctgtt agcaaatcaa caaaaacata gtgatgcagg agcaactatt   120
gaagatgaat attatgtatt tatcgctgag agtaaaattg atggcaagaa ggaagttatt   180
cagtgttgca tgggtgcggc aagggatttt ttagaactaa ttaatcacaa agggctacct   240
ctttttaatc cgcttgtagg tgattctcat gtaaataata gacaagaata tgacaataca   300
gggagtggaa attta                                                    315

<210>   2078
<211>   105
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902993 (6.E-59)

<400>   2078
Met Asn Cys Arg Gly His Glu Thr Arg Gln Arg Ile Val Arg Asp Phe 
1               5                   10                  15      

Glu Val Gln Pro Lys Ala His Ile Lys Leu Leu Ala Asn Gln Gln Lys 
            20                  25                  30          

His Ser Asp Ala Gly Ala Thr Ile Glu Asp Glu Tyr Tyr Val Phe Ile 
        35                  40                  45              

Ala Glu Ser Lys Ile Asp Gly Lys Lys Glu Val Ile Gln Cys Cys Met 
    50                  55                  60                  

Gly Ala Ala Arg Asp Phe Leu Glu Leu Ile Asn His Lys Gly Leu Pro 
65                  70                  75                  80  

Leu Phe Asn Pro Leu Val Gly Asp Ser His Val Asn Asn Arg Gln Glu 
                85                  90                  95      

Tyr Asp Asn Thr Gly Ser Gly Asn Leu 
            100                 105 

<210>   2079
<211>   279
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2079
atgtggttga ttattttatg gaatgctaag ccggatacac ctttatttaa ttttaaagac   60
gaagtaatta agtataaaac atatgagcct tttgaaagca gtataaaaag agtaaatact   120
actataaaga atggtagtaa agggaaaact ctgactgaga tgattaatgg ctacagagcg   180
gataacgata ttagagatga aatttgtaac tttaatattc tgaaaaataa aattcgtgat   240
atgaaaaacc aacaaggaaa tacaatggaa tcttacttt                          279

<210>   2080
<211>   93
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902994 (8.E-52)

<400>   2080
Met Trp Leu Ile Ile Leu Trp Asn Ala Lys Pro Asp Thr Pro Leu Phe 
1               5                   10                  15      

Asn Phe Lys Asp Glu Val Ile Lys Tyr Lys Thr Tyr Glu Pro Phe Glu 
            20                  25                  30          

Ser Ser Ile Lys Arg Val Asn Thr Thr Ile Lys Asn Gly Ser Lys Gly 
        35                  40                  45              

Lys Thr Leu Thr Glu Met Ile Asn Gly Tyr Arg Ala Asp Asn Asp Ile 
    50                  55                  60                  

Arg Asp Glu Ile Cys Asn Phe Asn Ile Leu Lys Asn Lys Ile Arg Asp 
65                  70                  75                  80  

Met Lys Asn Gln Gln Gly Asn Thr Met Glu Ser Tyr Phe 
                85                  90              

<210>   2081
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2081
atgtggagtg ttgctacaac gaaaaaggtg ataatccttg atttcaagct attttataag   60
cattttgtct ttgtagataa aggcaatttt gacaataaaa atcctaaaag g            111

<210>   2082
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2082
Met Trp Ser Val Ala Thr Thr Lys Lys Val Ile Ile Leu Asp Phe Lys 
1               5                   10                  15      

Leu Phe Tyr Lys His Phe Val Phe Val Asp Lys Gly Asn Phe Asp Asn 
            20                  25                  30          

Lys Asn Pro Lys Arg 
        35          

<210>   2083
<211>   531
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2083
ttggtgcgtt atgctttttt atgctataat ggatttataa aaataaagga gtttgctatg   60
attggaaaga acataaaatc cttgcgtaaa acacatgact taacacaact cgaatttgca   120
cggattgtag gtatttcacg aaatagtctg agtcgttatg aaaatggaac gagttcagtc   180
tctaccgaat taatagacat catttgtcag aagtttaatg tatcttatgt cgatattgta   240
ggagaagata aaatgctcaa tcctgttgaa gattatgaat tgactttaaa aattgaaatt   300
gtgaaagaaa gaggtgctaa tctattatct cgactctatc gttatcaaga tagtcaggga   360
attagcattg atgatgagtc taatccttgg attttaatga gtgatgatct atctgatttg   420
attcatacga atatctatct agtagaaact tttgatgaaa tagagagata tagtggctat   480
ttggatggaa ttgaacgtat gttagagata tctgaaaaac ggatggtggc c            531

<210>   2084
<211>   177
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902995 (1.E-85)

<400>   2084
Met Val Arg Tyr Ala Phe Leu Cys Tyr Asn Gly Phe Ile Lys Ile Lys 
1               5                   10                  15      

Glu Phe Ala Met Ile Gly Lys Asn Ile Lys Ser Leu Arg Lys Thr His 
            20                  25                  30          

Asp Leu Thr Gln Leu Glu Phe Ala Arg Ile Val Gly Ile Ser Arg Asn 
        35                  40                  45              

Ser Leu Ser Arg Tyr Glu Asn Gly Thr Ser Ser Val Ser Thr Glu Leu 
    50                  55                  60                  

Ile Asp Ile Ile Cys Gln Lys Phe Asn Val Ser Tyr Val Asp Ile Val 
65                  70                  75                  80  

Gly Glu Asp Lys Met Leu Asn Pro Val Glu Asp Tyr Glu Leu Thr Leu 
                85                  90                  95      

Lys Ile Glu Ile Val Lys Glu Arg Gly Ala Asn Leu Leu Ser Arg Leu 
            100                 105                 110         

Tyr Arg Tyr Gln Asp Ser Gln Gly Ile Ser Ile Asp Asp Glu Ser Asn 
        115                 120                 125             

Pro Trp Ile Leu Met Ser Asp Asp Leu Ser Asp Leu Ile His Thr Asn 
    130                 135                 140                 

Ile Tyr Leu Val Glu Thr Phe Asp Glu Ile Glu Arg Tyr Ser Gly Tyr 
145                 150                 155                 160 

Leu Asp Gly Ile Glu Arg Met Leu Glu Ile Ser Glu Lys Arg Met Val 
                165                 170                 175     

Ala 
    

<210>   2085
<211>   759
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2085

atggaaatcc aagattatac tgatagtgaa ttcaaacatg ctttagcaag gaatcttcgt   60
tcactgacaa gaggaaaaaa gtccagtaag caacctatag cgattttgct tggagggcaa   120
agtggtgccg gtaagactac aattcatcgt attaaacaga aagaatttca aggaaatatt   180
gttatcatag atggtgatag ttttcgttct cagcatccac actatttaga actgcagcaa   240
gaatatggca aagacagtgt agaatatacc aaagattttg caggaaaaat ggtagagtct   300
ttagtaacaa aattgagtag tttgagatac aatcttttga tagagggaac tttacgaaca   360
gttgatgttc caaagaaaac agcacaactc ttgaaaaata agggatatga agtacaattg   420
gccttaattg cgacaaagcc tgaattgtcg tatctaagta ctcttatccg ttatgaagaa   480
ctgtacatta tcaatccaaa tcaagcacgc gcaactccaa aagaacatca tgatttcatt   540
gtaaatcatc tagttgataa cacacgaaaa ttggaagaac tagctatctt tgaaagaatt   600
caaatttacc aacgagatag aagttgtgta tatgattcaa aagaaaatac aacttcagca   660
gcagatgttc ttcaagagtt actctttggg gagtggagtc aggtagagaa ggagatgttg   720
caggtggggg aaaagagact taatgaatta cttgaaaaa                          759

<210>   2086
<211>   253
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902996 (e-141)

<400>   2086
Met Glu Ile Gln Asp Tyr Thr Asp Ser Glu Phe Lys His Ala Leu Ala 
1               5                   10                  15      

Arg Asn Leu Arg Ser Leu Thr Arg Gly Lys Lys Ser Ser Lys Gln Pro 
            20                  25                  30          

Ile Ala Ile Leu Leu Gly Gly Gln Ser Gly Ala Gly Lys Thr Thr Ile 
        35                  40                  45              

His Arg Ile Lys Gln Lys Glu Phe Gln Gly Asn Ile Val Ile Ile Asp 
    50                  55                  60                  

Gly Asp Ser Phe Arg Ser Gln His Pro His Tyr Leu Glu Leu Gln Gln 
65                  70                  75                  80  

Glu Tyr Gly Lys Asp Ser Val Glu Tyr Thr Lys Asp Phe Ala Gly Lys 
                85                  90                  95      

Met Val Glu Ser Leu Val Thr Lys Leu Ser Ser Leu Arg Tyr Asn Leu 
            100                 105                 110         

Leu Ile Glu Gly Thr Leu Arg Thr Val Asp Val Pro Lys Lys Thr Ala 
        115                 120                 125             

Gln Leu Leu Lys Asn Lys Gly Tyr Glu Val Gln Leu Ala Leu Ile Ala 
    130                 135                 140                 

Thr Lys Pro Glu Leu Ser Tyr Leu Ser Thr Leu Ile Arg Tyr Glu Glu 
145                 150                 155                 160 

Leu Tyr Ile Ile Asn Pro Asn Gln Ala Arg Ala Thr Pro Lys Glu His 
                165                 170                 175     

His Asp Phe Ile Val Asn His Leu Val Asp Asn Thr Arg Lys Leu Glu 
            180                 185                 190         

Glu Leu Ala Ile Phe Glu Arg Ile Gln Ile Tyr Gln Arg Asp Arg Ser 
        195                 200                 205             

Cys Val Tyr Asp Ser Lys Glu Asn Thr Thr Ser Ala Ala Asp Val Leu 
    210                 215                 220                 

Gln Glu Leu Leu Phe Gly Glu Trp Ser Gln Val Glu Lys Glu Met Leu 
225                 230                 235                 240 

Gln Val Gly Glu Lys Arg Leu Asn Glu Leu Leu Glu Lys 
                245                 250             

<210>   2087
<211>   774
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2087
atgagagggt ttaataacaa gataaagtct gtttatcaag aactaacaaa ttccaaagag   60
aaattcggta gctttcacaa gactttaatt catttgcata cacctgtttc ttatgattac   120
aagctatttt ctaattggac tgcaacgaaa tatagaaaaa ttactgaaga tgaactatat   180
gatatatttt ttgaaaataa gaaaataaaa gttgataaga caattttttt tagtaatttt   240
gataaggttg ttttttctag ttcaaaagaa tatattagtt ttcttatgtt agcagaggca   300
atcataaaaa atggaataga aatagttgta gtaactgatc ataatactac caaaggtatt   360
aaaaagttac aaatggcagt ctcaatcata atgaaaaatt atccgattta tgatatacat   420
cctcatattt tacatggagt agaaattagt gcagcagata aattgcatat tgtatgtata   480
tatgattatg aacaagaatc atgggttaat caatggttaa gtgaaaatat tataagtgag   540
aaagatggaa gttatcaaca ttcactgact ataatgaagg atttcaataa tcaaaaaata   600
gttaactata ttgctcattt caatagttat gacattttga aaaaaggttc tcacttatca   660
ggtgcatata aacgaaaaat tttttctaaa gaaaatacac gattttggag tttaatatta   720
actcgaaaga atcttcgcaa caacttgata ttctctataa agaagttggt gtat         774

<210>   2088
<211>   258
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoesterase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902997 (e-150)

<400>   2088
Met Arg Gly Phe Asn Asn Lys Ile Lys Ser Val Tyr Gln Glu Leu Thr 
1               5                   10                  15      

Asn Ser Lys Glu Lys Phe Gly Ser Phe His Lys Thr Leu Ile His Leu 
            20                  25                  30          

His Thr Pro Val Ser Tyr Asp Tyr Lys Leu Phe Ser Asn Trp Thr Ala 
        35                  40                  45              

Thr Lys Tyr Arg Lys Ile Thr Glu Asp Glu Leu Tyr Asp Ile Phe Phe 
    50                  55                  60                  

Glu Asn Lys Lys Ile Lys Val Asp Lys Thr Ile Phe Phe Ser Asn Phe 
65                  70                  75                  80  

Asp Lys Val Val Phe Ser Ser Ser Lys Glu Tyr Ile Ser Phe Leu Met 
                85                  90                  95      

Leu Ala Glu Ala Ile Ile Lys Asn Gly Ile Glu Ile Val Val Val Thr 
            100                 105                 110         

Asp His Asn Thr Thr Lys Gly Ile Lys Lys Leu Gln Met Ala Val Ser 
        115                 120                 125             

Ile Ile Met Lys Asn Tyr Pro Ile Tyr Asp Ile His Pro His Ile Leu 
    130                 135                 140                 

His Gly Val Glu Ile Ser Ala Ala Asp Lys Leu His Ile Val Cys Ile 
145                 150                 155                 160 

Tyr Asp Tyr Glu Gln Glu Ser Trp Val Asn Gln Trp Leu Ser Glu Asn 
                165                 170                 175     

Ile Ile Ser Glu Lys Asp Gly Ser Tyr Gln His Ser Leu Thr Ile Met 
            180                 185                 190         

Lys Asp Phe Asn Asn Gln Lys Ile Val Asn Tyr Ile Ala His Phe Asn 
        195                 200                 205             

Ser Tyr Asp Ile Leu Lys Lys Gly Ser His Leu Ser Gly Ala Tyr Lys 
    210                 215                 220                 

Arg Lys Ile Phe Ser Lys Glu Asn Thr Arg Phe Trp Ser Leu Ile Leu 
225                 230                 235                 240 

Thr Arg Lys Asn Leu Arg Asn Asn Leu Ile Phe Ser Ile Lys Lys Leu 
                245                 250                 255     

Val Tyr 
        

<210>   2089
<211>   375
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2089
ttgggacaaa aagttgtagc catgcttgat tttttattag catatagtga ttattctaaa   60
gacttcagac cattgattat tgatcagcct gaagacaatc tagacaatcg ttatatttac   120
aggcatttag ttcagcagtt tagagatgtg aaagctcaac gtcaaattat tttagcaaca   180
cataatgcta caattgtaac aaattctatg acagatcaag ttgttattat ggagtcagat   240
ggagttaacg gatggattga atcacaggga tatgttagtg aaaaatatat aaaaaatcat   300
atcatcaatc aattagaggg aggaaaagat tccttcaagc ataaaatgtc tatatatgag   360
acggctttat cagag                                                    375

<210>   2090
<211>   125
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902998 (1.E-68)

<400>   2090
Met Gly Gln Lys Val Val Ala Met Leu Asp Phe Leu Leu Ala Tyr Ser 
1               5                   10                  15      

Asp Tyr Ser Lys Asp Phe Arg Pro Leu Ile Ile Asp Gln Pro Glu Asp 
            20                  25                  30          

Asn Leu Asp Asn Arg Tyr Ile Tyr Arg His Leu Val Gln Gln Phe Arg 
        35                  40                  45              

Asp Val Lys Ala Gln Arg Gln Ile Ile Leu Ala Thr His Asn Ala Thr 
    50                  55                  60                  

Ile Val Thr Asn Ser Met Thr Asp Gln Val Val Ile Met Glu Ser Asp 
65                  70                  75                  80  

Gly Val Asn Gly Trp Ile Glu Ser Gln Gly Tyr Val Ser Glu Lys Tyr 
                85                  90                  95      

Ile Lys Asn His Ile Ile Asn Gln Leu Glu Gly Gly Lys Asp Ser Phe 
            100                 105                 110         

Lys His Lys Met Ser Ile Tyr Glu Thr Ala Leu Ser Glu 
        115                 120                 125 

<210>   2091
<211>   354
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2091
atgaaacgag atgtgcgtga tattcggaaa caatttcgtt taacagaagc agaagaaaag   60
caaattctag ctttgatgag agagcgggga gagactaatt tctctgattt tcttcgtaaa   120
agtttacttt cctctgattt acaaaaacag atggagacat ggtttgccct ctggcaatcc   180
caaaaactag aacaaatcag tcgtgacgtt catgaagttt taatcttggc acagtcagaa   240
cgtcaagtca cccaagagca tgtatctatt ctcttaacgt gcgtgcagga attgattcaa   300
gaggttgcaa acaccatacc cctcagtaaa gaatttcgtg agaagtacat gagg         354

<210>   2092
<211>   118
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Tn5252, Orf 10 protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902999 (2.E-37)

<400>   2092
Met Lys Arg Asp Val Arg Asp Ile Arg Lys Gln Phe Arg Leu Thr Glu 
1               5                   10                  15      

Ala Glu Glu Lys Gln Ile Leu Ala Leu Met Arg Glu Arg Gly Glu Thr 
            20                  25                  30          

Asn Phe Ser Asp Phe Leu Arg Lys Ser Leu Leu Ser Ser Asp Leu Gln 
        35                  40                  45              

Lys Gln Met Glu Thr Trp Phe Ala Leu Trp Gln Ser Gln Lys Leu Glu 
    50                  55                  60                  

Gln Ile Ser Arg Asp Val His Glu Val Leu Ile Leu Ala Gln Ser Glu 
65                  70                  75                  80  

Arg Gln Val Thr Gln Glu His Val Ser Ile Leu Leu Thr Cys Val Gln 

                85                  90                  95      

Glu Leu Ile Gln Glu Val Ala Asn Thr Ile Pro Leu Ser Lys Glu Phe 
            100                 105                 110         

Arg Glu Lys Tyr Met Arg 
        115             


<210>   2093
<211>   363
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2093
atggaacatc gttaccgaac caatctcaag aaagtgtttt tgtctgatag tgagttgaac   60
caactaaata taaatatcga tcaaagtggt tgtaaatcct tttctgaata tgcgagacga   120
actctactcg atcctggtat gaattttatc acgattgaca caaacggtta ccaagattta   180
gtgtttgagt taaagaggat tggcaataat atcaaccaga ttgctcgaag tgttaatcaa   240
tctcagttaa tttctggtga agaattgcag gagttgaaaa aaggaattgg tgaattgata   300
aaagaagttg ataaggaatt taatctgcaa gcgcagaagc taaaggagtt ccatggtcat   360
cac                                                                 363

<210>   2094
<211>   121
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Tn5252, Orf 9 protein FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903000 (3.E-39)

<400>   2094
Met Glu His Arg Tyr Arg Thr Asn Leu Lys Lys Val Phe Leu Ser Asp 
1               5                   10                  15      

Ser Glu Leu Asn Gln Leu Asn Ile Asn Ile Asp Gln Ser Gly Cys Lys 
            20                  25                  30          

Ser Phe Ser Glu Tyr Ala Arg Arg Thr Leu Leu Asp Pro Gly Met Asn 
        35                  40                  45              

Phe Ile Thr Ile Asp Thr Asn Gly Tyr Gln Asp Leu Val Phe Glu Leu 
    50                  55                  60                  

Lys Arg Ile Gly Asn Asn Ile Asn Gln Ile Ala Arg Ser Val Asn Gln 
65                  70                  75                  80  

Ser Gln Leu Ile Ser Gly Glu Glu Leu Gln Glu Leu Lys Lys Gly Ile 
                85                  90                  95      

Gly Glu Leu Ile Lys Glu Val Asp Lys Glu Phe Asn Leu Gln Ala Gln 
            100                 105                 110         

Lys Leu Lys Glu Phe His Gly His His 
        115                 120     

<210>   2095
<211>   1821
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2095
atggtcatca ctaaacactt tgccattcac ggaaagagtt accgcagaaa gcttatcaag   60
tacattctca atcctgagaa aaccaataat cttgccttgg tgtcggacta tggcatgaag   120
aattttctgg actttcctag ctatgaggaa atggtgcaga tgtatcatga aaatttcatc   180
agcaacgata cgctttacga ttttcgccac gacaggatgg aagaaaatca acgaaaaata   240
cacgctcacc acatcattca gtctttctcg ccagaggatc atatcactcc tgaacaaatc   300
aatcggatag gttatgagac tgtgaaggaa ttaactggtg gcaaatttcg ttttatcgtt   360
gcgacccatg ttgataaaga ccacctgcac aatcacatca ttatcaattc agtagatagc   420
aattctgaca aaaagctcaa gtgggactac aaggtggagc gaaatcttcg catgatttct   480
gaccgttttt ctaaaatcgc aggtgctaaa atcattgaga accgctattc tcaccagcgg   540
tatgaagtct atcgtaagac taatcacaag tatgaactca agcagcgact ctattttttg   600
atggaacatt ctagggactt tgaggatttc aaaaagaatg ctccgctact acatgtggag   660
atggatttcc gtcacaagca tgccaccttt tttattacgg actcaactat gaaacaggtg   720
gtgcgtggca agcaactcaa tcgcaagcag ccttacacag aagaattttt taagaactac   780
tttgccaaaa gagaaataga aagtctcatg gaatttttat tgctgaaagt tgagaatatg   840
gatgatttac ttcagaaagc aaaacttttt ggactaacta tcaatcctaa acaaaagcat   900
gtttcttttc aatttgcagg agtggaggta aaggagacag agctagacca gaaaaatctt   960
tatgatgtag agtttttcca agattatttt aaaaatagaa aagattggca agctccagaa   1020
actgaggatt tcgttcaact ttatcaagaa gaaaagttat ccaaagaaaa agaacttcca   1080
agcgatgaga agttctggga gtcctatcaa gagttcaaga gtaacagaga tgccgttcat   1140
gaatttgagg tggagttgtc actcaatcaa attgaaaaag tagtggatga tggaatttac   1200
gtcaaggtca agtttggtat tcgtcaggag ggacttatct ttgtgccgaa catgcagctt   1260
gatatggaag aggataaggt gaaggttttc atcagggaaa ccagctccta ctatgtctac   1320
cacaaagacg ctgccgagaa aaattgttat atgaaaggtc gaaccttaat tagacagttc   1380
agctatgaaa atcaaaccat tccattacgc agaaaagcga cagtcgatat gattaaagag   1440
aagattgcgg aagtggatgc tttgattgaa ctggaagtag aaaatcaatc ttatgtcacg   1500
attaaagatg agttagtgca tgaactagca gcgtctgaat tgagaatcaa tgagttgcaa   1560
gaacgaatgt caaccttgaa tcaagtagca gaatatctac tggcttcagt tgaaagtaag   1620
caagaaatga aattaaatct ttcaaaactg aatataactg agaatatcag tgctaatatt   1680
gttgagaaaa aattgaagag cctggggaat caactggaat tggaaagggg caggtatgaa   1740
aagatggtag tcaggctaga taaatttata aatcgcttaa atacaggact ttcaaaagga   1800
gatgggatag attttcaaaa a                                             1821

<210>   2096
<211>   607
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Tn5252, relaxase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903001 (4.E-89)

<400>   2096
Met Val Ile Thr Lys His Phe Ala Ile His Gly Lys Ser Tyr Arg Arg 
1               5                   10                  15      

Lys Leu Ile Lys Tyr Ile Leu Asn Pro Glu Lys Thr Asn Asn Leu Ala 
            20                  25                  30          

Leu Val Ser Asp Tyr Gly Met Lys Asn Phe Leu Asp Phe Pro Ser Tyr 
        35                  40                  45              

Glu Glu Met Val Gln Met Tyr His Glu Asn Phe Ile Ser Asn Asp Thr 
    50                  55                  60                  

Leu Tyr Asp Phe Arg His Asp Arg Met Glu Glu Asn Gln Arg Lys Ile 
65                  70                  75                  80  

His Ala His His Ile Ile Gln Ser Phe Ser Pro Glu Asp His Ile Thr 
                85                  90                  95      

Pro Glu Gln Ile Asn Arg Ile Gly Tyr Glu Thr Val Lys Glu Leu Thr 
            100                 105                 110         

Gly Gly Lys Phe Arg Phe Ile Val Ala Thr His Val Asp Lys Asp His 
        115                 120                 125             

Leu His Asn His Ile Ile Ile Asn Ser Val Asp Ser Asn Ser Asp Lys 
    130                 135                 140                 

Lys Leu Lys Trp Asp Tyr Lys Val Glu Arg Asn Leu Arg Met Ile Ser 
145                 150                 155                 160 

Asp Arg Phe Ser Lys Ile Ala Gly Ala Lys Ile Ile Glu Asn Arg Tyr 
                165                 170                 175     

Ser His Gln Arg Tyr Glu Val Tyr Arg Lys Thr Asn His Lys Tyr Glu 
            180                 185                 190         

Leu Lys Gln Arg Leu Tyr Phe Leu Met Glu His Ser Arg Asp Phe Glu 
        195                 200                 205             

Asp Phe Lys Lys Asn Ala Pro Leu Leu His Val Glu Met Asp Phe Arg 
    210                 215                 220                 

His Lys His Ala Thr Phe Phe Ile Thr Asp Ser Thr Met Lys Gln Val 
225                 230                 235                 240 

Val Arg Gly Lys Gln Leu Asn Arg Lys Gln Pro Tyr Thr Glu Glu Phe 
                245                 250                 255     

Phe Lys Asn Tyr Phe Ala Lys Arg Glu Ile Glu Ser Leu Met Glu Phe 
            260                 265                 270         

Leu Leu Leu Lys Val Glu Asn Met Asp Asp Leu Leu Gln Lys Ala Lys 
        275                 280                 285             

Leu Phe Gly Leu Thr Ile Asn Pro Lys Gln Lys His Val Ser Phe Gln 
    290                 295                 300                 

Phe Ala Gly Val Glu Val Lys Glu Thr Glu Leu Asp Gln Lys Asn Leu 
305                 310                 315                 320 

Tyr Asp Val Glu Phe Phe Gln Asp Tyr Phe Lys Asn Arg Lys Asp Trp 
                325                 330                 335     

Gln Ala Pro Glu Thr Glu Asp Phe Val Gln Leu Tyr Gln Glu Glu Lys 
            340                 345                 350         

Leu Ser Lys Glu Lys Glu Leu Pro Ser Asp Glu Lys Phe Trp Glu Ser 
        355                 360                 365             

Tyr Gln Glu Phe Lys Ser Asn Arg Asp Ala Val His Glu Phe Glu Val 
    370                 375                 380                 

Glu Leu Ser Leu Asn Gln Ile Glu Lys Val Val Asp Asp Gly Ile Tyr 
385                 390                 395                 400 

Val Lys Val Lys Phe Gly Ile Arg Gln Glu Gly Leu Ile Phe Val Pro 
                405                 410                 415     

Asn Met Gln Leu Asp Met Glu Glu Asp Lys Val Lys Val Phe Ile Arg 
            420                 425                 430         

Glu Thr Ser Ser Tyr Tyr Val Tyr His Lys Asp Ala Ala Glu Lys Asn 
        435                 440                 445             

Cys Tyr Met Lys Gly Arg Thr Leu Ile Arg Gln Phe Ser Tyr Glu Asn 
    450                 455                 460                 

Gln Thr Ile Pro Leu Arg Arg Lys Ala Thr Val Asp Met Ile Lys Glu 
465                 470                 475                 480 

Lys Ile Ala Glu Val Asp Ala Leu Ile Glu Leu Glu Val Glu Asn Gln 
                485                 490                 495     

Ser Tyr Val Thr Ile Lys Asp Glu Leu Val His Glu Leu Ala Ala Ser 
            500                 505                 510         

Glu Leu Arg Ile Asn Glu Leu Gln Glu Arg Met Ser Thr Leu Asn Gln 
        515                 520                 525             

Val Ala Glu Tyr Leu Leu Ala Ser Val Glu Ser Lys Gln Glu Met Lys 
    530                 535                 540                 

Leu Asn Leu Ser Lys Leu Asn Ile Thr Glu Asn Ile Ser Ala Asn Ile 
545                 550                 555                 560 

Val Glu Lys Lys Leu Lys Ser Leu Gly Asn Gln Leu Glu Leu Glu Arg 
                565                 570                 575     

Gly Arg Tyr Glu Lys Met Val Val Arg Leu Asp Lys Phe Ile Asn Arg 
            580                 585                 590         

Leu Asn Thr Gly Leu Ser Lys Gly Asp Gly Ile Asp Phe Gln Lys 
        595                 600                 605         

<210>   2097
<211>   864
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2097
gtgggtacac tattagcaac aagattaaaa aatagacgaa aagaattaaa aatgtctcag   60
cgagaattag ctgagggtat ctgtaaacag gggcaaatta gtcgattaga gagtggagag   120
ttcacccctg gagcggattt tttacatgcc cttgctaaga aattaaaagt tagtatggac   180
tacttttttg atgagcaggt tgtagaggaa gtcaatgagt tatcagagtt taagaagtta   240
gcacagacat ttatcacaaa tcgtaattat gaatctttaa aatatatata tgaattggaa   300
aatgtaaaag cccatcgctt atctctagca gataaatttt acatggaatg gataaagtct   360
cttatagatt tttattttta tggacagaaa gaagaggcaa ttacacgatt agagaatatg   420
ctacctcagt taaatgtatc tgatttgaac taccttcaag tttcaaacac tctattcaat   480
ttttattatg atattgaaga tttagaacgt tttaatgaga ttagagacaa gctagagcat   540
caagtgaatc agcttaattt aaacacaatt gaagagttag aactatcaat taagttcaat   600
tataacgttt gtcgatacct atggttacag aaaaatattg aagaagctat tacgaaaatc   660
acagctacga taaagcaatg taaggagtac aggacaactt atctattagc tgatttgtat   720
ttattgatgg gaagtgtaag tgaaaatttt tcttctaaaa gttcagtaaa agaatatttt   780
gagactgctc attttctcta caaacttgag gaaaacatgt caatggcttt gaaagtcgaa   840
cattattttg cagatataac agaa                                          864

<210>   2098
<211>   288
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator PlcR, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903805 (4.E-56)

<400>   2098
Met Gly Thr Leu Leu Ala Thr Arg Leu Lys Asn Arg Arg Lys Glu Leu 
1               5                   10                  15      

Lys Met Ser Gln Arg Glu Leu Ala Glu Gly Ile Cys Lys Gln Gly Gln 
            20                  25                  30          

Ile Ser Arg Leu Glu Ser Gly Glu Phe Thr Pro Gly Ala Asp Phe Leu 
        35                  40                  45              

His Ala Leu Ala Lys Lys Leu Lys Val Ser Met Asp Tyr Phe Phe Asp 
    50                  55                  60                  

Glu Gln Val Val Glu Glu Val Asn Glu Leu Ser Glu Phe Lys Lys Leu 
65                  70                  75                  80  

Ala Gln Thr Phe Ile Thr Asn Arg Asn Tyr Glu Ser Leu Lys Tyr Ile 
                85                  90                  95      

Tyr Glu Leu Glu Asn Val Lys Ala His Arg Leu Ser Leu Ala Asp Lys 
            100                 105                 110         

Phe Tyr Met Glu Trp Ile Lys Ser Leu Ile Asp Phe Tyr Phe Tyr Gly 
        115                 120                 125             

Gln Lys Glu Glu Ala Ile Thr Arg Leu Glu Asn Met Leu Pro Gln Leu 
    130                 135                 140                 

Asn Val Ser Asp Leu Asn Tyr Leu Gln Val Ser Asn Thr Leu Phe Asn 
145                 150                 155                 160 

Phe Tyr Tyr Asp Ile Glu Asp Leu Glu Arg Phe Asn Glu Ile Arg Asp 
                165                 170                 175     

Lys Leu Glu His Gln Val Asn Gln Leu Asn Leu Asn Thr Ile Glu Glu 
            180                 185                 190         

Leu Glu Leu Ser Ile Lys Phe Asn Tyr Asn Val Cys Arg Tyr Leu Trp 
        195                 200                 205             

Leu Gln Lys Asn Ile Glu Glu Ala Ile Thr Lys Ile Thr Ala Thr Ile 
    210                 215                 220                 

Lys Gln Cys Lys Glu Tyr Arg Thr Thr Tyr Leu Leu Ala Asp Leu Tyr 
225                 230                 235                 240 

Leu Leu Met Gly Ser Val Ser Glu Asn Phe Ser Ser Lys Ser Ser Val 
                245                 250                 255     

Lys Glu Tyr Phe Glu Thr Ala His Phe Leu Tyr Lys Leu Glu Glu Asn 
            260                 265                 270         

Met Ser Met Ala Leu Lys Val Glu His Tyr Phe Ala Asp Ile Thr Glu 
        275                 280                 285             


<210>   2099
<211>   132
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2099
atgagaagtt tgtttaggaa aattgttgct ttgttagtca taggattaat cctattaggg   60
actgctggag gaactcaagt tcataagatg gctagaggga ttgatccagg tcctgcgaat   120
ggtatttata ga                                                       132

<210>   2100
<211>   44
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside

<400>   2100
Met Arg Ser Leu Phe Arg Lys Ile Val Ala Leu Leu Val Ile Gly Leu 
1               5                   10                  15      

Ile Leu Leu Gly Thr Ala Gly Gly Thr Gln Val His Lys Met Ala Arg 
            20                  25                  30          

Gly Ile Asp Pro Gly Pro Ala Asn Gly Ile Tyr Arg 
        35                  40                  

<210>   2101
<211>   249
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2101
atgagtagtc aaatgaaagc tttcttgaat gaacttcaag gaaatatgga agttgttgga   60
gaattttttg ataatcctga aaaggtaatt agaaaatttg gaattgtcgg aagagagaag   120
gaagcattgc taatccgtga cttaaatgat atggatgatt atgctctttc aattcaaaat   180
agcgttgcat cgccttctgg ggcacatagt agcacttgcc attttgttag acaagattta   240
caatccgca                                                           249

<210>   2102
<211>   83
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2102
Met Ser Ser Gln Met Lys Ala Phe Leu Asn Glu Leu Gln Gly Asn Met 
1               5                   10                  15      

Glu Val Val Gly Glu Phe Phe Asp Asn Pro Glu Lys Val Ile Arg Lys 
            20                  25                  30          

Phe Gly Ile Val Gly Arg Glu Lys Glu Ala Leu Leu Ile Arg Asp Leu 
        35                  40                  45              

Asn Asp Met Asp Asp Tyr Ala Leu Ser Ile Gln Asn Ser Val Ala Ser 
    50                  55                  60                  

Pro Ser Gly Ala His Ser Ser Thr Cys His Phe Val Arg Gln Asp Leu 
65                  70                  75                  80  

Gln Ser Ala 
            

<210>   2103
<211>   309
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2103
gtggccgata tgaaaaataa atacgatgtt aaaagaatta ttccggatga attatcagaa   60
tcactagata tttttctaaa aaattattct gaaactggat tgtcagatta taatacttat   120
ctcttttatg gttttatctt gaagtcctat aaattgcctc gagaaaatag atatagcata   180
aaattattgg tgaaggaatt acaaaataga ggactgaaag ttacattgat tatcaacatt   240
tattatcacg ctttaaattg tttggcttta aatgatggtc taaaaattta tggagaagat   300
ttcttaata                                                           309

<210>   2104
<211>   103
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2104
Met Ala Asp Met Lys Asn Lys Tyr Asp Val Lys Arg Ile Ile Pro Asp 
1               5                   10                  15      

Glu Leu Ser Glu Ser Leu Asp Ile Phe Leu Lys Asn Tyr Ser Glu Thr 
            20                  25                  30          

Gly Leu Ser Asp Tyr Asn Thr Tyr Leu Phe Tyr Gly Phe Ile Leu Lys 
        35                  40                  45              

Ser Tyr Lys Leu Pro Arg Glu Asn Arg Tyr Ser Ile Lys Leu Leu Val 
    50                  55                  60                  

Lys Glu Leu Gln Asn Arg Gly Leu Lys Val Thr Leu Ile Ile Asn Ile 
65                  70                  75                  80  

Tyr Tyr His Ala Leu Asn Cys Leu Ala Leu Asn Asp Gly Leu Lys Ile 
                85                  90                  95      

Tyr Gly Glu Asp Phe Leu Ile 
            100             

<210>   2105
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2105
atgaattacg aaaagtattt aaactatttg gactatgaaa ctgaaataga agacgcatac   60
cataatttat tattagaata taaaattagt gataatttta gtgatgaaca ttggttatat   120
aatttgccgt ctaatatcac ccaatctaag ggatttaaaa tacacctgag cgcttcaata   180
ttaaatgcta atttggttgc taaaaaattc tttgatttta tattttctag agagaagaag   240
ataaatttca aaattttggt tagcattaaa gaactttctt tgcaaaatac agggcttaat   300
ggttattcac aagtcgggaa attcattaca atttatccaa aagataataa agagtttcaa   360
cgtttgttac acaaattaga aatattgtat aaaggtgtaa agggtgtaaa cataccatca   420
gatttcagat ttcaacttag cgaggttgta tattacagat atggggagtt cgtaaaagat   480
agcactttca aggataaaag agataagaaa atcccttcaa atgtgaatgt tccaataagg   540
gattactata ttccaagata taacactatt cctgatcaat atattatttt ggaagtgatt   600
tctaaaaatg ccaaaggtgg agtttataaa gtatttaata ctcaaaagcg agtttattct   660
ttattaaaag aagctagtga tttatcgttg gttgatttta caaatagaga ttctgtgaat   720
cgtttaataa atgaaagaga aatattagta gaattggaaa aggaggaatt tactccaaaa   780
gtttttaacg atttttacat aaagaattcg tattttgtgg aatttgagtt tattattgca   840
gataaattaa gcgagtataa tatggttagt ggctcgtatg attggttttt aacattaatt   900
gattatatgg agataataaa ctccaaatat aatctttcct atagagattt atcatttaat   960
aatatactta ttgataatag aaataatatt tatattatag actttgagca tgccctaagg   1020
aaagaaactc aaattgaaga aaaaaagttg cctctatttg gaactccagg gttttatgaa   1080
accaacttaa atttattgaa taatcaacca gaggatatta tgggattggt tttgttatta   1140
tattggagtc agaatttaga tgattttaac gtcttttcaa aaatgagttt tttagaagcg   1200
atggagtatg caatgaattt taattcgcgt cgcttagaca cacttgataa atcagattgg   1260
ctttatgata tttataaaaa agcgttcaat tataaatatg atactttttc tgaattaaaa   1320
aaagatttta tagaggtatt aaaa                                          1344

<210>   2106
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   protein kinase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903248 (6.E-19)

<400>   2106
Met Asn Tyr Glu Lys Tyr Leu Asn Tyr Leu Asp Tyr Glu Thr Glu Ile 
1               5                   10                  15      

Glu Asp Ala Tyr His Asn Leu Leu Leu Glu Tyr Lys Ile Ser Asp Asn 
            20                  25                  30          

Phe Ser Asp Glu His Trp Leu Tyr Asn Leu Pro Ser Asn Ile Thr Gln 
        35                  40                  45              

Ser Lys Gly Phe Lys Ile His Leu Ser Ala Ser Ile Leu Asn Ala Asn 
    50                  55                  60                  

Leu Val Ala Lys Lys Phe Phe Asp Phe Ile Phe Ser Arg Glu Lys Lys 
65                  70                  75                  80  

Ile Asn Phe Lys Ile Leu Val Ser Ile Lys Glu Leu Ser Leu Gln Asn 
                85                  90                  95      

Thr Gly Leu Asn Gly Tyr Ser Gln Val Gly Lys Phe Ile Thr Ile Tyr 
            100                 105                 110         

Pro Lys Asp Asn Lys Glu Phe Gln Arg Leu Leu His Lys Leu Glu Ile 
        115                 120                 125             

Leu Tyr Lys Gly Val Lys Gly Val Asn Ile Pro Ser Asp Phe Arg Phe 
    130                 135                 140                 

Gln Leu Ser Glu Val Val Tyr Tyr Arg Tyr Gly Glu Phe Val Lys Asp 
145                 150                 155                 160 

Ser Thr Phe Lys Asp Lys Arg Asp Lys Lys Ile Pro Ser Asn Val Asn 
                165                 170                 175     

Val Pro Ile Arg Asp Tyr Tyr Ile Pro Arg Tyr Asn Thr Ile Pro Asp 
            180                 185                 190         

Gln Tyr Ile Ile Leu Glu Val Ile Ser Lys Asn Ala Lys Gly Gly Val 
        195                 200                 205             

Tyr Lys Val Phe Asn Thr Gln Lys Arg Val Tyr Ser Leu Leu Lys Glu 
    210                 215                 220                 

Ala Ser Asp Leu Ser Leu Val Asp Phe Thr Asn Arg Asp Ser Val Asn 
225                 230                 235                 240 

Arg Leu Ile Asn Glu Arg Glu Ile Leu Val Glu Leu Glu Lys Glu Glu 
                245                 250                 255     

Phe Thr Pro Lys Val Phe Asn Asp Phe Tyr Ile Lys Asn Ser Tyr Phe 
            260                 265                 270         

Val Glu Phe Glu Phe Ile Ile Ala Asp Lys Leu Ser Glu Tyr Asn Met 
        275                 280                 285             

Val Ser Gly Ser Tyr Asp Trp Phe Leu Thr Leu Ile Asp Tyr Met Glu 
    290                 295                 300                 

Ile Ile Asn Ser Lys Tyr Asn Leu Ser Tyr Arg Asp Leu Ser Phe Asn 
305                 310                 315                 320 

Asn Ile Leu Ile Asp Asn Arg Asn Asn Ile Tyr Ile Ile Asp Phe Glu 
                325                 330                 335     

His Ala Leu Arg Lys Glu Thr Gln Ile Glu Glu Lys Lys Leu Pro Leu 
            340                 345                 350         

Phe Gly Thr Pro Gly Phe Tyr Glu Thr Asn Leu Asn Leu Leu Asn Asn 
        355                 360                 365             

Gln Pro Glu Asp Ile Met Gly Leu Val Leu Leu Leu Tyr Trp Ser Gln 
    370                 375                 380                 

Asn Leu Asp Asp Phe Asn Val Phe Ser Lys Met Ser Phe Leu Glu Ala 
385                 390                 395                 400 

Met Glu Tyr Ala Met Asn Phe Asn Ser Arg Arg Leu Asp Thr Leu Asp 
                405                 410                 415     

Lys Ser Asp Trp Leu Tyr Asp Ile Tyr Lys Lys Ala Phe Asn Tyr Lys 
            420                 425                 430         

Tyr Asp Thr Phe Ser Glu Leu Lys Lys Asp Phe Ile Glu Val Leu Lys 
        435                 440                 445             


<210>   2107
<211>   915
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2107
atgaattgtt tcttgaaaat gaataatgta agtgttcgtt atgatgacgt aatagcttta   60
aaagatataa ctttacaaat aaataaggga gatttcattg gcttattagg ttcaaatggt   120
gcaggtaaat ctacgttaat taattctatt gtaggttttc aagagattta tttaggagaa   180
atagagtatt gtgataaaga tttgatagtt agttctcaac cttttgctca tttaggcttt   240
actcctcaaa ccacagtaat tgatttttat actactgtga aggacaatgt aatattgggg   300
ctgaaccttg ctggaaagtt tgggaaaaat gctgagaagt tgtgtcaaat agccttagaa   360
attgttgggt tagctgataa aaaaaataat ttggtagaaa cattgtcagg tggacaactg   420
caacgcgtcc agattgctag agcaatagct cataatccag atttttatat tttagatgaa   480
cctaccgttg gtttagatac tgaatctgcc gaaaaatttt taatgtattt aaaagataag   540
agtttggaag gaaaaactat tatcatatct tcacatgaca taaatctact cgaaaagttt   600
tgtaaaaaaa tacttttttt acaaaatggc tccatatcat tttttggtga tatgcgtgac   660
tttgtagata attcaactat caaattaaat ttttcaatgc agaatagaat ttctagatat   720
caaattgaat ttttagaaaa ttttagattt aaagttcaca tcgaagataa tgatagtttt   780
acaatagaag tccctataga agaaaagatc ttagatgtta tcaatgaggt aggaaaagca   840
tgtgaaatta aaaacttttc aacaagtaaa ttaaccttac aagaaagtta tttgcaaaga   900

ataggaggag aaaaa                                                    915

<210>   2108
<211>   305
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903535 (1.E-29)

<400>   2108
Met Asn Cys Phe Leu Lys Met Asn Asn Val Ser Val Arg Tyr Asp Asp 
1               5                   10                  15      

Val Ile Ala Leu Lys Asp Ile Thr Leu Gln Ile Asn Lys Gly Asp Phe 
            20                  25                  30          

Ile Gly Leu Leu Gly Ser Asn Gly Ala Gly Lys Ser Thr Leu Ile Asn 
        35                  40                  45              

Ser Ile Val Gly Phe Gln Glu Ile Tyr Leu Gly Glu Ile Glu Tyr Cys 
    50                  55                  60                  

Asp Lys Asp Leu Ile Val Ser Ser Gln Pro Phe Ala His Leu Gly Phe 
65                  70                  75                  80  

Thr Pro Gln Thr Thr Val Ile Asp Phe Tyr Thr Thr Val Lys Asp Asn 
                85                  90                  95      


Val Ile Leu Gly Leu Asn Leu Ala Gly Lys Phe Gly Lys Asn Ala Glu 
            100                 105                 110         

Lys Leu Cys Gln Ile Ala Leu Glu Ile Val Gly Leu Ala Asp Lys Lys 
        115                 120                 125             

Asn Asn Leu Val Glu Thr Leu Ser Gly Gly Gln Leu Gln Arg Val Gln 
    130                 135                 140                 

Ile Ala Arg Ala Ile Ala His Asn Pro Asp Phe Tyr Ile Leu Asp Glu 
145                 150                 155                 160 

Pro Thr Val Gly Leu Asp Thr Glu Ser Ala Glu Lys Phe Leu Met Tyr 
                165                 170                 175     

Leu Lys Asp Lys Ser Leu Glu Gly Lys Thr Ile Ile Ile Ser Ser His 
            180                 185                 190         

Asp Ile Asn Leu Leu Glu Lys Phe Cys Lys Lys Ile Leu Phe Leu Gln 
        195                 200                 205             

Asn Gly Ser Ile Ser Phe Phe Gly Asp Met Arg Asp Phe Val Asp Asn 
    210                 215                 220                 

Ser Thr Ile Lys Leu Asn Phe Ser Met Gln Asn Arg Ile Ser Arg Tyr 
225                 230                 235                 240 

Gln Ile Glu Phe Leu Glu Asn Phe Arg Phe Lys Val His Ile Glu Asp 
                245                 250                 255     

Asn Asp Ser Phe Thr Ile Glu Val Pro Ile Glu Glu Lys Ile Leu Asp 
            260                 265                 270         

Val Ile Asn Glu Val Gly Lys Ala Cys Glu Ile Lys Asn Phe Ser Thr 
        275                 280                 285             

Ser Lys Leu Thr Leu Gln Glu Ser Tyr Leu Gln Arg Ile Gly Gly Glu 
    290                 295                 300                 

Lys 
305 

<210>   2109
<211>   798
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2109
atgaaggctg atcaattaag gcacaaatcg gacttaggtt taagaggtct agcgattatt   60
gctaaaaatg agattattgc tttttttaga agtaaaggtt taattatttc tcagtttcta   120
caaccaatct tatatgttgt ttttataata ataggattaa attcttcgat aaagaacatt   180
cagtttaatg atataaaaac ctcttatgca gaatatacaa tcattggtgt tatagcttta   240
ttgataatcg ggcagatgac tcaagttatt tatagggtga caatagataa aaaatatggg   300
ctacttgctc ttaagttatg cagtggagtt cgtcctttat attatatttt agggatgagt   360
atctattcta tattagggtt gatagttcaa gaaattatta tatatataat tacgttagcg   420
tttgagataa atatcgcaat ggatagattt ttttatacag ttttgttatc tattgttgtt   480
ttattatttt gggactccct tgcaatttta cttacaatgt ttatcaatga ttacagaaga   540
cgtgatattg taatacgttt tgtactaaca ccgcttggtt ttacagctcc tgttttctac   600
ttaatagatt ctgctcctag tattgtgaga tggattggtc agttaaatcc cttaacttat   660
caattaacta ttttgagaaa cttttatttt aaaaattcaa caactttgga attagttttc   720
ttattgttaa catcattact tgtccttata tctgtatctt ttattatacc aaagataaaa   780
ttgatactga tagaaaga                                                 798

<210>   2110
<211>   266
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC-2 transporter, permease protein, putative
<223>   Cellular location: membrane

<400>   2110
Met Lys Ala Asp Gln Leu Arg His Lys Ser Asp Leu Gly Leu Arg Gly 
1               5                   10                  15      

Leu Ala Ile Ile Ala Lys Asn Glu Ile Ile Ala Phe Phe Arg Ser Lys 
            20                  25                  30          

Gly Leu Ile Ile Ser Gln Phe Leu Gln Pro Ile Leu Tyr Val Val Phe 
        35                  40                  45              

Ile Ile Ile Gly Leu Asn Ser Ser Ile Lys Asn Ile Gln Phe Asn Asp 
    50                  55                  60                  

Ile Lys Thr Ser Tyr Ala Glu Tyr Thr Ile Ile Gly Val Ile Ala Leu 
65                  70                  75                  80  

Leu Ile Ile Gly Gln Met Thr Gln Val Ile Tyr Arg Val Thr Ile Asp 
                85                  90                  95      

Lys Lys Tyr Gly Leu Leu Ala Leu Lys Leu Cys Ser Gly Val Arg Pro 
            100                 105                 110         

Leu Tyr Tyr Ile Leu Gly Met Ser Ile Tyr Ser Ile Leu Gly Leu Ile 
        115                 120                 125             

Val Gln Glu Ile Ile Ile Tyr Ile Ile Thr Leu Ala Phe Glu Ile Asn 
    130                 135                 140                 

Ile Ala Met Asp Arg Phe Phe Tyr Thr Val Leu Leu Ser Ile Val Val 
145                 150                 155                 160 

Leu Leu Phe Trp Asp Ser Leu Ala Ile Leu Leu Thr Met Phe Ile Asn 
                165                 170                 175     

Asp Tyr Arg Arg Arg Asp Ile Val Ile Arg Phe Val Leu Thr Pro Leu 
            180                 185                 190         

Gly Phe Thr Ala Pro Val Phe Tyr Leu Ile Asp Ser Ala Pro Ser Ile 
        195                 200                 205             

Val Arg Trp Ile Gly Gln Leu Asn Pro Leu Thr Tyr Gln Leu Thr Ile 
    210                 215                 220                 

Leu Arg Asn Phe Tyr Phe Lys Asn Ser Thr Thr Leu Glu Leu Val Phe 
225                 230                 235                 240 

Leu Leu Leu Thr Ser Leu Leu Val Leu Ile Ser Val Ser Phe Ile Ile 
                245                 250                 255     

Pro Lys Ile Lys Leu Ile Leu Ile Glu Arg 
            260                 265     

<210>   2111
<211>   471
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2111
atgagagagg ataatcaaag tttatcacat accacatgga attgtaaata tcatattgtt   60
tttgcaccca aatatcgtcg tcaaatcatt tatggcagat acaaagctag tatcggaaga   120
atcatacgtg acttatgtga gcgtaagggt gtaataatcc atgaagcgaa tgcttgttca   180
gaccatattc acatgcttat cagtattcct ccgaaactta gtgtttcgtc ctttatgggc   240
tatttaaagg gcaagagcag tttgatgatt tttgataagc atgcgaattt aaaatacaaa   300
tatggcaatc gcaagttttg gtgtagaggc tattatgtag atacggtagg ccgtaatcag   360
aaagtgatag ctgaatatat tcagaatcaa ttacaagaag acagagtagc agaccagctc   420
acgttattcg agtcagtaga tccgtttact ggcgaaataa ataagaggaa g            471

<210>   2112
<211>   157
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, IS200 family
<223>   Cellular location: cytoplasm

<400>   2112
Met Arg Glu Asp Asn Gln Ser Leu Ser His Thr Thr Trp Asn Cys Lys 
1               5                   10                  15      

Tyr His Ile Val Phe Ala Pro Lys Tyr Arg Arg Gln Ile Ile Tyr Gly 
            20                  25                  30          

Arg Tyr Lys Ala Ser Ile Gly Arg Ile Ile Arg Asp Leu Cys Glu Arg 
        35                  40                  45              

Lys Gly Val Ile Ile His Glu Ala Asn Ala Cys Ser Asp His Ile His 
    50                  55                  60                  

Met Leu Ile Ser Ile Pro Pro Lys Leu Ser Val Ser Ser Phe Met Gly 
65                  70                  75                  80  

Tyr Leu Lys Gly Lys Ser Ser Leu Met Ile Phe Asp Lys His Ala Asn 
                85                  90                  95      

Leu Lys Tyr Lys Tyr Gly Asn Arg Lys Phe Trp Cys Arg Gly Tyr Tyr 
            100                 105                 110         

Val Asp Thr Val Gly Arg Asn Gln Lys Val Ile Ala Glu Tyr Ile Gln 
        115                 120                 125             

Asn Gln Leu Gln Glu Asp Arg Val Ala Asp Gln Leu Thr Leu Phe Glu 
    130                 135                 140                 

Ser Val Asp Pro Phe Thr Gly Glu Ile Asn Lys Arg Lys 
145                 150                 155         

<210>   2113
<211>   192
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2113
atgaatgatg aagcaagtaa acaattgagc gatagccgtt tcaagatcct tgtaggtgtt   60
cagcgcacga cttttgaaga gatgttagct gtgttaaaaa cagcttatca acgtaaacgc   120
gcaaaaggtg gacgaaaaag caaattaagc ctagacgatc tccttatggt aactattcaa   180
tacatgcgag aa                                                       192

<210>   2114
<211>   64
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA, truncation POINT MUTATION

<400>   2114
Met Asn Asp Glu Ala Ser Lys Gln Leu Ser Asp Ser Arg Phe Lys Ile 
1               5                   10                  15      

Leu Val Gly Val Gln Arg Thr Thr Phe Glu Glu Met Leu Ala Val Leu 
            20                  25                  30          

Lys Thr Ala Tyr Gln Arg Lys Arg Ala Lys Gly Gly Arg Lys Ser Lys 
        35                  40                  45              

Leu Ser Leu Asp Asp Leu Leu Met Val Thr Ile Gln Tyr Met Arg Glu 
    50                  55                  60                  


<210>   2115
<211>   1227
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2115
atgaagatta gtaagaggca cttattaaat tattccatct tgattcccta cttgctttta   60
tctattttgg gcttgattgt ggtctattcg accaccagtg ctattttaat tgaagaaggc   120
aagagcgcct tgcagttggt tcgaaaccaa ggaatctttt ggattgttag tttgatactg   180
attgccttaa tttataaatt gagactagat tttttgagaa atgagcgact aatcatttta   240
gttatattaa tagaaatgct tttattgttc ttggctcgtt ttattggtat ttccgtaaac   300
ggggcatacg gttggatttc ggttgcagga ataactattc agccagctga gtacttaaaa   360
atcattatta tttggtattt agctcaccga ttctccaaac agcaagaaga aatagctact   420
tatgattttc aagttttgac tcaaaatcaa tggcttcccc gtgcttttaa tgattggcga   480
ttcgttctcc tagttctgat tggaagtttg ggaattttcc ctgatttagg aaatgcgact   540
attttagtct tggtttcctt gattatgtat acagttagtg gaatcgctta tcgctggttt   600
tcaaccattc tggcgctcgt atctgccgct tctgtctttg tcttgaccac tatcagccta   660
atcggtgttg agaccttttc aaaaattcca gtattcggct atgtagccaa gcgctttagt   720
gcctttttta atccttttgc cgatcgtgct gatgcaggtc accagttagc taattcttat   780
tttgccatgg tcaatggcgg ttggtttggt ctaggtcttg gaaactcgat tgaaaaacga   840
ggttatttgc cagaagctca tacagacttt gtcttttcta tcgtgattga agaatttggc   900
tttgttggtg ccagtcttat tttagctctc ttgtttttca tgattttgcg gattatcttg   960
gtcggtatcc gagcggagaa tcctttcaat gccatggttg cactcggtgt cggagggatg   1020
atgttggttc aggtatttgt caatatcgga gggatttcgg gcttgattcc atctacagga   1080
gtgactttcc ccttcttatc ccagggtgga aatagtcttc tagtcttatc agtggcagta   1140
gcctttgtct taaatattga tgccagtgaa aaacgcgcta aattgtaccg agaattggaa   1200
aatcaaccaa tgaaccttct gttgaag                                       1227

<210>   2116
<211>   409
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell division protein FtsW, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903017 (0.E+01)

<400>   2116
Met Lys Ile Ser Lys Arg His Leu Leu Asn Tyr Ser Ile Leu Ile Pro 
1               5                   10                  15      

Tyr Leu Leu Leu Ser Ile Leu Gly Leu Ile Val Val Tyr Ser Thr Thr 
            20                  25                  30          

Ser Ala Ile Leu Ile Glu Glu Gly Lys Ser Ala Leu Gln Leu Val Arg 
        35                  40                  45              

Asn Gln Gly Ile Phe Trp Ile Val Ser Leu Ile Leu Ile Ala Leu Ile 
    50                  55                  60                  

Tyr Lys Leu Arg Leu Asp Phe Leu Arg Asn Glu Arg Leu Ile Ile Leu 
65                  70                  75                  80  

Val Ile Leu Ile Glu Met Leu Leu Leu Phe Leu Ala Arg Phe Ile Gly 
                85                  90                  95      

Ile Ser Val Asn Gly Ala Tyr Gly Trp Ile Ser Val Ala Gly Ile Thr 
            100                 105                 110         

Ile Gln Pro Ala Glu Tyr Leu Lys Ile Ile Ile Ile Trp Tyr Leu Ala 
        115                 120                 125             

His Arg Phe Ser Lys Gln Gln Glu Glu Ile Ala Thr Tyr Asp Phe Gln 
    130                 135                 140                 

Val Leu Thr Gln Asn Gln Trp Leu Pro Arg Ala Phe Asn Asp Trp Arg 
145                 150                 155                 160 

Phe Val Leu Leu Val Leu Ile Gly Ser Leu Gly Ile Phe Pro Asp Leu 
                165                 170                 175     

Gly Asn Ala Thr Ile Leu Val Leu Val Ser Leu Ile Met Tyr Thr Val 
            180                 185                 190         

Ser Gly Ile Ala Tyr Arg Trp Phe Ser Thr Ile Leu Ala Leu Val Ser 
        195                 200                 205             

Ala Ala Ser Val Phe Val Leu Thr Thr Ile Ser Leu Ile Gly Val Glu 
    210                 215                 220                 

Thr Phe Ser Lys Ile Pro Val Phe Gly Tyr Val Ala Lys Arg Phe Ser 
225                 230                 235                 240 

Ala Phe Phe Asn Pro Phe Ala Asp Arg Ala Asp Ala Gly His Gln Leu 
                245                 250                 255     

Ala Asn Ser Tyr Phe Ala Met Val Asn Gly Gly Trp Phe Gly Leu Gly 
            260                 265                 270         

Leu Gly Asn Ser Ile Glu Lys Arg Gly Tyr Leu Pro Glu Ala His Thr 
        275                 280                 285             

Asp Phe Val Phe Ser Ile Val Ile Glu Glu Phe Gly Phe Val Gly Ala 
    290                 295                 300                 

Ser Leu Ile Leu Ala Leu Leu Phe Phe Met Ile Leu Arg Ile Ile Leu 
305                 310                 315                 320 

Val Gly Ile Arg Ala Glu Asn Pro Phe Asn Ala Met Val Ala Leu Gly 
                325                 330                 335     

Val Gly Gly Met Met Leu Val Gln Val Phe Val Asn Ile Gly Gly Ile 
            340                 345                 350         

Ser Gly Leu Ile Pro Ser Thr Gly Val Thr Phe Pro Phe Leu Ser Gln 
        355                 360                 365             

Gly Gly Asn Ser Leu Leu Val Leu Ser Val Ala Val Ala Phe Val Leu 
    370                 375                 380                 

Asn Ile Asp Ala Ser Glu Lys Arg Ala Lys Leu Tyr Arg Glu Leu Glu 
385                 390                 395                 400 

Asn Gln Pro Met Asn Leu Leu Leu Lys 
                405                 

<210>   2117
<211>   2694
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2117
atgtctcttc aaaaattaga aaattatagt aataaaagtg ttgtgcaaga agaagtcttg   60

attctaacag aattactgga agatattact aaaaatatgc ttgccccaga gacctttgaa   120
aaaataatac agttgaaaga attatcaacg caggaagatt atcaaggtct aaaccgtcta   180
gtgactagct tatcaaatga tgaaatggtc tatatttcac gctatttctc tatcttgcct   240
cttttgatta atatttcaga ggatgtggat ttagcttatg aaatcaatca tcaaaataat   300
attgatcagg actatttagg taaattatct acaacgatta aattggtagc agaaaaggaa   360
aatgccgttg agatcctaga acacttgaat gttgtccctg ttttgacagc ccatccaaca   420
caagtgcaac gcaaaagtat gttggattta acaaatcata ttcatagtct tttgcgtaaa   480
taccgtgatg ttaagttggg gttgatcaat aaagataaat ggtacaatga tttgcgtcgt   540
tacatcgaaa ttatcatgca gacagacatg attcgtgaga aaaaattaaa agtgactaac   600
gaaatcacga atgctatgga atattataac agctcctttt tgaaagctgt acctcatttg   660
acgacggagt ataagcgctt agcgcaagcg catggtctga atttaaaaca ggctaaacca   720
atcaccatgg gtatgtggat aggtggtgac cgtgatggaa atccatttgt tacagcaaag   780
accttgaagc agtctgcact cactcagtgt gaagtcatca tgaactacta tgataaaaag   840
atttaccaac tttatcgtga attttctctt tcaactagca ttgtcaacgt cagcaagcaa   900
gtcagagaaa tggctcgtca atccaaggat aactcgattt accgcgaaaa agagctttac   960
cgtcgtgcct tgtttgatat tcaatcaaaa attcaggcaa ctaaaaccta tctgattgag   1020
gatgaagaag ttgggactcg ttatgaaacc gccaatgatt tctacaagga tttgattgcc   1080
attcgagatt ctctactaga aaataagggc gagtccttga tttcaggtga ttttgtggaa   1140
ttattgcagg cagtagagat atttggtttt tacttagcat caattgatat gcgacaagac   1200
tctagcgtct atgaagcctg tgtggcagaa ctcttgaaat cagcaggaat tcattctcgt   1260
tatagcgagt tgagcgaaga agaaaagtgt gaccttctct tgaaagaatt agaagaagat   1320
ccccgaattc tttctgcgac tcacgcagaa aaatcagaat tattagcaaa agaattagct   1380
atttttaaga cggctcgtgt tttgaaagat aagttgggag atgatgtcat ccgtcagacc   1440
atcatttcac atgcaaccag cctttctgat atgctagaat tagctattct gttaaaagaa   1500
gtaggactgg tggatacgga aagggcgcgt gttcagattg ttcccctttt tgaaacaatt   1560
gaagacttgg atcattcaga ggaaacaatg agaaaatatc tttctcttag ccttgccaaa   1620
aaatggattg actcacgaaa taactaccaa gaaatcatgc ttggctactc tgacagtaat   1680
aaagatggcg gttacttgtc atcatgttgg accctctaca aggctcaaca acaattgact   1740
gctattggag atgaatttgg cgttaaggtt accttcttcc atggtcgtgg tggtactgtc   1800
ggtcgtggtg gtgggccaac ctatgaagcc attacatctc aaccgctcaa gtctatcaag   1860
gatcgtatcc gcttgacgga gcagggtgaa gtaattggga ataaatacgg taacaaagac   1920
gccgcttact ataaccttga aatgctagta tcggcagcta ttaaccgtat gattactcag   1980
aagaagagcg ataccaatac cccaaatcgt tatgaaacca ttatggatca agtagtggac   2040
cgtagttacg atatctaccg tgatttggtc tttggtaatg agcatttcta tgattatttc   2100
ttcgagtcaa gtccaatcaa ggctatttca agttttaata ttggttctcg tccagccgct   2160
cgtaagacta ttactgaaat cggtggtttg cgtgccatcc cttgggtatt ctcatggtca   2220
cagagtcgtg ttatgttccc tggatggtac ggggttggtt caagcttcaa ggaatttatc   2280
aataaaaatc cagagaatat tgctatctta cgagatatgt accaaaattg gcctttcttc   2340
caatcgcttc tttcaaatgt tgatatggtt ttgtcaaaat caaatatgaa tattgctttt   2400
gaatatgcta aactttgtga agacgagcaa gttaaggcca tctatgagac tattttaaat   2460
gaatggcaag ttactaagaa cgttatcttg gctattgaag gacatgacga actcttagct   2520
gacaatccat atctaaaagc tagtctggat taccgtatgc cttactttaa tattctcaac   2580
tatattcagt tggagttgat taaacgccaa cgtcgtggag aattgtccag tgatcaagaa   2640
cgattgattc atatcaccat caacggaatt gcgacaggat tgcgtaattc aggt         2694

<210>   2118
<211>   898
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoenolpyruvate carboxylase (ppc)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903018 (0.E+01)

<400>   2118
Met Ser Leu Gln Lys Leu Glu Asn Tyr Ser Asn Lys Ser Val Val Gln 
1               5                   10                  15      

Glu Glu Val Leu Ile Leu Thr Glu Leu Leu Glu Asp Ile Thr Lys Asn 
            20                  25                  30          

Met Leu Ala Pro Glu Thr Phe Glu Lys Ile Ile Gln Leu Lys Glu Leu 
        35                  40                  45              

Ser Thr Gln Glu Asp Tyr Gln Gly Leu Asn Arg Leu Val Thr Ser Leu 
    50                  55                  60                  

Ser Asn Asp Glu Met Val Tyr Ile Ser Arg Tyr Phe Ser Ile Leu Pro 
65                  70                  75                  80  

Leu Leu Ile Asn Ile Ser Glu Asp Val Asp Leu Ala Tyr Glu Ile Asn 
                85                  90                  95      

His Gln Asn Asn Ile Asp Gln Asp Tyr Leu Gly Lys Leu Ser Thr Thr 
            100                 105                 110         

Ile Lys Leu Val Ala Glu Lys Glu Asn Ala Val Glu Ile Leu Glu His 
        115                 120                 125             

Leu Asn Val Val Pro Val Leu Thr Ala His Pro Thr Gln Val Gln Arg 
    130                 135                 140                 

Lys Ser Met Leu Asp Leu Thr Asn His Ile His Ser Leu Leu Arg Lys 
145                 150                 155                 160 

Tyr Arg Asp Val Lys Leu Gly Leu Ile Asn Lys Asp Lys Trp Tyr Asn 
                165                 170                 175     

Asp Leu Arg Arg Tyr Ile Glu Ile Ile Met Gln Thr Asp Met Ile Arg 
            180                 185                 190         

Glu Lys Lys Leu Lys Val Thr Asn Glu Ile Thr Asn Ala Met Glu Tyr 
        195                 200                 205             

Tyr Asn Ser Ser Phe Leu Lys Ala Val Pro His Leu Thr Thr Glu Tyr 
    210                 215                 220                 

Lys Arg Leu Ala Gln Ala His Gly Leu Asn Leu Lys Gln Ala Lys Pro 
225                 230                 235                 240 

Ile Thr Met Gly Met Trp Ile Gly Gly Asp Arg Asp Gly Asn Pro Phe 
                245                 250                 255     

Val Thr Ala Lys Thr Leu Lys Gln Ser Ala Leu Thr Gln Cys Glu Val 
            260                 265                 270         

Ile Met Asn Tyr Tyr Asp Lys Lys Ile Tyr Gln Leu Tyr Arg Glu Phe 
        275                 280                 285             

Ser Leu Ser Thr Ser Ile Val Asn Val Ser Lys Gln Val Arg Glu Met 
    290                 295                 300                 

Ala Arg Gln Ser Lys Asp Asn Ser Ile Tyr Arg Glu Lys Glu Leu Tyr 
305                 310                 315                 320 

Arg Arg Ala Leu Phe Asp Ile Gln Ser Lys Ile Gln Ala Thr Lys Thr 
                325                 330                 335     

Tyr Leu Ile Glu Asp Glu Glu Val Gly Thr Arg Tyr Glu Thr Ala Asn 
            340                 345                 350         

Asp Phe Tyr Lys Asp Leu Ile Ala Ile Arg Asp Ser Leu Leu Glu Asn 
        355                 360                 365             

Lys Gly Glu Ser Leu Ile Ser Gly Asp Phe Val Glu Leu Leu Gln Ala 
    370                 375                 380                 

Val Glu Ile Phe Gly Phe Tyr Leu Ala Ser Ile Asp Met Arg Gln Asp 
385                 390                 395                 400 

Ser Ser Val Tyr Glu Ala Cys Val Ala Glu Leu Leu Lys Ser Ala Gly 
                405                 410                 415     

Ile His Ser Arg Tyr Ser Glu Leu Ser Glu Glu Glu Lys Cys Asp Leu 
            420                 425                 430         

Leu Leu Lys Glu Leu Glu Glu Asp Pro Arg Ile Leu Ser Ala Thr His 
        435                 440                 445             

Ala Glu Lys Ser Glu Leu Leu Ala Lys Glu Leu Ala Ile Phe Lys Thr 
    450                 455                 460                 

Ala Arg Val Leu Lys Asp Lys Leu Gly Asp Asp Val Ile Arg Gln Thr 
465                 470                 475                 480 

Ile Ile Ser His Ala Thr Ser Leu Ser Asp Met Leu Glu Leu Ala Ile 
                485                 490                 495     

Leu Leu Lys Glu Val Gly Leu Val Asp Thr Glu Arg Ala Arg Val Gln 
            500                 505                 510         

Ile Val Pro Leu Phe Glu Thr Ile Glu Asp Leu Asp His Ser Glu Glu 
        515                 520                 525             

Thr Met Arg Lys Tyr Leu Ser Leu Ser Leu Ala Lys Lys Trp Ile Asp 
    530                 535                 540                 

Ser Arg Asn Asn Tyr Gln Glu Ile Met Leu Gly Tyr Ser Asp Ser Asn 
545                 550                 555                 560 

Lys Asp Gly Gly Tyr Leu Ser Ser Cys Trp Thr Leu Tyr Lys Ala Gln 
                565                 570                 575     

Gln Gln Leu Thr Ala Ile Gly Asp Glu Phe Gly Val Lys Val Thr Phe 
            580                 585                 590         

Phe His Gly Arg Gly Gly Thr Val Gly Arg Gly Gly Gly Pro Thr Tyr 
        595                 600                 605             

Glu Ala Ile Thr Ser Gln Pro Leu Lys Ser Ile Lys Asp Arg Ile Arg 
    610                 615                 620                 

Leu Thr Glu Gln Gly Glu Val Ile Gly Asn Lys Tyr Gly Asn Lys Asp 
625                 630                 635                 640 

Ala Ala Tyr Tyr Asn Leu Glu Met Leu Val Ser Ala Ala Ile Asn Arg 
                645                 650                 655     

Met Ile Thr Gln Lys Lys Ser Asp Thr Asn Thr Pro Asn Arg Tyr Glu 
            660                 665                 670         

Thr Ile Met Asp Gln Val Val Asp Arg Ser Tyr Asp Ile Tyr Arg Asp 
        675                 680                 685             

Leu Val Phe Gly Asn Glu His Phe Tyr Asp Tyr Phe Phe Glu Ser Ser 
    690                 695                 700                 

Pro Ile Lys Ala Ile Ser Ser Phe Asn Ile Gly Ser Arg Pro Ala Ala 
705                 710                 715                 720 

Arg Lys Thr Ile Thr Glu Ile Gly Gly Leu Arg Ala Ile Pro Trp Val 
                725                 730                 735     

Phe Ser Trp Ser Gln Ser Arg Val Met Phe Pro Gly Trp Tyr Gly Val 
            740                 745                 750         

Gly Ser Ser Phe Lys Glu Phe Ile Asn Lys Asn Pro Glu Asn Ile Ala 
        755                 760                 765             

Ile Leu Arg Asp Met Tyr Gln Asn Trp Pro Phe Phe Gln Ser Leu Leu 
    770                 775                 780                 

Ser Asn Val Asp Met Val Leu Ser Lys Ser Asn Met Asn Ile Ala Phe 
785                 790                 795                 800 

Glu Tyr Ala Lys Leu Cys Glu Asp Glu Gln Val Lys Ala Ile Tyr Glu 
                805                 810                 815     

Thr Ile Leu Asn Glu Trp Gln Val Thr Lys Asn Val Ile Leu Ala Ile 
            820                 825                 830         

Glu Gly His Asp Glu Leu Leu Ala Asp Asn Pro Tyr Leu Lys Ala Ser 
        835                 840                 845             

Leu Asp Tyr Arg Met Pro Tyr Phe Asn Ile Leu Asn Tyr Ile Gln Leu 
    850                 855                 860                 

Glu Leu Ile Lys Arg Gln Arg Arg Gly Glu Leu Ser Ser Asp Gln Glu 
865                 870                 875                 880 

Arg Leu Ile His Ile Thr Ile Asn Gly Ile Ala Thr Gly Leu Arg Asn 
                885                 890                 895     

Ser Gly 
        

<210>   2119
<211>   1032
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2119
atgttaaagg aaataaaaag gagaaacaga atgaaaaata aacgtttaat tggaattatt   60
gctgcattag cagtcttagt agcaggaagc ttgatttatt cttcaatgaa taaatcagaa   120
gctcagaata ataaggatga gaagaaaata accaagattg gtgtgcttca atttgtgagc   180
catccatccc ttgatttgat ttataaaggg atccaagatg gacttgcaga agaaggatat   240
aaagatgatc aagttaaaat tgattttatg aactcagaag gtgaccaaag taaggttgcg   300
acaatgagta aacaattggt tgcaaatggg aatgaccttg tggttggtat cgcaacacca   360
gcagcccaag ggttggctag tgcaacaaaa gacctaccgg ttatcatggc cgctattaca   420
gacccaattg gtgctaactt ggttaaagat ttgaaaaaac caggtggcaa cgttacaggg   480
gtatctgacc acaatccagc tcaacaacaa gttgaactca tcaaggctct gacaccgaat   540
gtgaaaacaa tcggagctct ttactcaagt agcgaagaca attcaaaaac acaggtcgaa   600
gaatttaagg cttatgctga aaaagcaggt ctgacagtgg aaacatttgc agttccttca   660
acaaatgaaa ttgcctcaac tgtcactgtt atgactagca aggtagatgc tatttgggtt   720
ccaattgata acaccattgc atcaggattt ccaacggttg tctctagcaa tcaaagttct   780
aagaaaccaa tttatcccag tgcgacagct atggtagaag taggtggttt ggcatcagtt   840
gtaattgacc aacatgacct tggtgtggca acaggtaaaa tgattgtgca agtcttgaaa   900
ggtgcaaaac cagccgatac cccagtcaat gtcttttcaa ctggtaagtc agtcatcaat   960
aaaaaaatag cacaagaact aggtattact attcctgagt ctgttctcaa agaagcagga   1020
caagtcatcg aa                                                       1032

<210>   2120
<211>   344
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (ABC transporter)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903019 (0.E+01)

<400>   2120
Met Leu Lys Glu Ile Lys Arg Arg Asn Arg Met Lys Asn Lys Arg Leu 
1               5                   10                  15      

Ile Gly Ile Ile Ala Ala Leu Ala Val Leu Val Ala Gly Ser Leu Ile 
            20                  25                  30          

Tyr Ser Ser Met Asn Lys Ser Glu Ala Gln Asn Asn Lys Asp Glu Lys 
        35                  40                  45              

Lys Ile Thr Lys Ile Gly Val Leu Gln Phe Val Ser His Pro Ser Leu 
    50                  55                  60                  

Asp Leu Ile Tyr Lys Gly Ile Gln Asp Gly Leu Ala Glu Glu Gly Tyr 
65                  70                  75                  80  

Lys Asp Asp Gln Val Lys Ile Asp Phe Met Asn Ser Glu Gly Asp Gln 
                85                  90                  95      

Ser Lys Val Ala Thr Met Ser Lys Gln Leu Val Ala Asn Gly Asn Asp 
            100                 105                 110         

Leu Val Val Gly Ile Ala Thr Pro Ala Ala Gln Gly Leu Ala Ser Ala 
        115                 120                 125             

Thr Lys Asp Leu Pro Val Ile Met Ala Ala Ile Thr Asp Pro Ile Gly 
    130                 135                 140                 

Ala Asn Leu Val Lys Asp Leu Lys Lys Pro Gly Gly Asn Val Thr Gly 
145                 150                 155                 160 

Val Ser Asp His Asn Pro Ala Gln Gln Gln Val Glu Leu Ile Lys Ala 
                165                 170                 175     

Leu Thr Pro Asn Val Lys Thr Ile Gly Ala Leu Tyr Ser Ser Ser Glu 
            180                 185                 190         

Asp Asn Ser Lys Thr Gln Val Glu Glu Phe Lys Ala Tyr Ala Glu Lys 
        195                 200                 205             

Ala Gly Leu Thr Val Glu Thr Phe Ala Val Pro Ser Thr Asn Glu Ile 
    210                 215                 220                 


Ala Ser Thr Val Thr Val Met Thr Ser Lys Val Asp Ala Ile Trp Val 
225                 230                 235                 240 

Pro Ile Asp Asn Thr Ile Ala Ser Gly Phe Pro Thr Val Val Ser Ser 
                245                 250                 255     

Asn Gln Ser Ser Lys Lys Pro Ile Tyr Pro Ser Ala Thr Ala Met Val 
            260                 265                 270         

Glu Val Gly Gly Leu Ala Ser Val Val Ile Asp Gln His Asp Leu Gly 
        275                 280                 285             

Val Ala Thr Gly Lys Met Ile Val Gln Val Leu Lys Gly Ala Lys Pro 
    290                 295                 300                 

Ala Asp Thr Pro Val Asn Val Phe Ser Thr Gly Lys Ser Val Ile Asn 
305                 310                 315                 320 

Lys Lys Ile Ala Gln Glu Leu Gly Ile Thr Ile Pro Glu Ser Val Leu 
                325                 330                 335     

Lys Glu Ala Gly Gln Val Ile Glu 
            340                 

<210>   2121

<211>   864
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2121
atgattgttt ccattatttc tcaaggattt gtctgggcta ttctaggtct gggaatcttt   60
atgacattta ggattttaaa ctttccagat atgacgacag aaggttcctt ccctcttggg   120
ggagctgttg ctgtcacttt gataaccaaa ggcgtgaacc catttttagc gacacttgtt   180
gctgtaggag caggttgttt ggctggaatg gcagcaggcc ttctttatac aaaagggaag   240
atcccaacct tgctctcagg gattttggtg atgacttctt gtcactcaat catgctcttg   300
attatgggac gtgcgaattt aggcctgctt ggaaccaagc aaattcagga tgttttgcct   360
tttgattcgg atttgaatca actcttgaca ggtctcatct ttgtgagtat tgttattgct   420
ctcatgctct ttttcttgga cactaaactc ggacaagcct atattgctac aggggataat   480
cctgatatgg ctagaagttt cgggattcat actggacgca tggagctcat gggcttggtc   540
ttatcaaatg gtgtgattgc ccttgcaggt gccctcattg ctcagcaaga aggttatgcc   600
gatgtgtctc gagggatcgg ggttatcgtt gtggggcttg caagtttgat tattggagaa   660
gttattttca agagtttgag cttggcagag cgtttggtta ctatcgttgt aggttctatc   720
gcttatcaat ttttagtgtg ggcagttatc gcacttggct ttaatacaag ttaccttcgt   780

ttatacagtg ccttgatttt agcagtctgc ctcatgattc caacatttaa gcaaacaatc   840
ttgaaaggag ccaagttaag caaa                                          864

<210>   2122
<211>   288
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (ABC transporter)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903020 (e-157)

<400>   2122
Met Ile Val Ser Ile Ile Ser Gln Gly Phe Val Trp Ala Ile Leu Gly 
1               5                   10                  15      

Leu Gly Ile Phe Met Thr Phe Arg Ile Leu Asn Phe Pro Asp Met Thr 
            20                  25                  30          

Thr Glu Gly Ser Phe Pro Leu Gly Gly Ala Val Ala Val Thr Leu Ile 
        35                  40                  45              

Thr Lys Gly Val Asn Pro Phe Leu Ala Thr Leu Val Ala Val Gly Ala 
    50                  55                  60                  

Gly Cys Leu Ala Gly Met Ala Ala Gly Leu Leu Tyr Thr Lys Gly Lys 
65                  70                  75                  80  

Ile Pro Thr Leu Leu Ser Gly Ile Leu Val Met Thr Ser Cys His Ser 
                85                  90                  95      

Ile Met Leu Leu Ile Met Gly Arg Ala Asn Leu Gly Leu Leu Gly Thr 
            100                 105                 110         

Lys Gln Ile Gln Asp Val Leu Pro Phe Asp Ser Asp Leu Asn Gln Leu 
        115                 120                 125             

Leu Thr Gly Leu Ile Phe Val Ser Ile Val Ile Ala Leu Met Leu Phe 
    130                 135                 140                 

Phe Leu Asp Thr Lys Leu Gly Gln Ala Tyr Ile Ala Thr Gly Asp Asn 
145                 150                 155                 160 

Pro Asp Met Ala Arg Ser Phe Gly Ile His Thr Gly Arg Met Glu Leu 
                165                 170                 175     

Met Gly Leu Val Leu Ser Asn Gly Val Ile Ala Leu Ala Gly Ala Leu 
            180                 185                 190         

Ile Ala Gln Gln Glu Gly Tyr Ala Asp Val Ser Arg Gly Ile Gly Val 
        195                 200                 205             

Ile Val Val Gly Leu Ala Ser Leu Ile Ile Gly Glu Val Ile Phe Lys 
    210                 215                 220                 

Ser Leu Ser Leu Ala Glu Arg Leu Val Thr Ile Val Val Gly Ser Ile 
225                 230                 235                 240 

Ala Tyr Gln Phe Leu Val Trp Ala Val Ile Ala Leu Gly Phe Asn Thr 
                245                 250                 255     

Ser Tyr Leu Arg Leu Tyr Ser Ala Leu Ile Leu Ala Val Cys Leu Met 
            260                 265                 270         

Ile Pro Thr Phe Lys Gln Thr Ile Leu Lys Gly Ala Lys Leu Ser Lys 
        275                 280                 285             


<210>   2123
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2123
atgacagcaa ttgtagaatt aaaaaatgca accaaaatcg ttaaaaatgg ctttgatgaa   60
gaaaagatta ttttaaatga tgtttcctta gaaatttttg aacgggactt tatcacgatt   120
ttgggcggaa atggtgctgg aaaatcaact ctctttaaca ctatagcagg gaccttatca   180
ctaactagtg gaactatccg tattttaggt gaagatctca ctaagttttc acccgagaag   240
cgtgccaagt acctgtctcg tgtcttccaa gatccaaaga tggggacagc tccccgtatg   300
acggtcgctg aaaatctttt aatcgccaag tttcgtggtg aaaagcgtgg attgttacca   360
cgacgcttga ctagctataa ggatgaattt caggcaacca ttgaaaaagt aggaaatggt   420
cttgagaaac acttgaatac accgattgag ttcttatcag gtggacaaag acaggctttg   480
agtctcttga tggcaacctt gaagcgacct gaattactcc tgttagatga gcatactgct   540
gccctggatc caaagactag tgttgctttg atggaattga cagatgaatt tgttaagaaa   600
gatcagctaa cagcccttat gattactcat catatggaag atgctctcaa atacggcaat   660
cgcttgattg tcatgaaaga aggacgaatt atccaagatt taaaccaaga agaaaaagca   720
aaaatgaaaa tctctgatta ttatcaactc tttgaa                             756

<210>   2124
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903021 (e-136)

<400>   2124
Met Thr Ala Ile Val Glu Leu Lys Asn Ala Thr Lys Ile Val Lys Asn 
1               5                   10                  15      

Gly Phe Asp Glu Glu Lys Ile Ile Leu Asn Asp Val Ser Leu Glu Ile 
            20                  25                  30          

Phe Glu Arg Asp Phe Ile Thr Ile Leu Gly Gly Asn Gly Ala Gly Lys 
        35                  40                  45              

Ser Thr Leu Phe Asn Thr Ile Ala Gly Thr Leu Ser Leu Thr Ser Gly 
    50                  55                  60                  

Thr Ile Arg Ile Leu Gly Glu Asp Leu Thr Lys Phe Ser Pro Glu Lys 
65                  70                  75                  80  

Arg Ala Lys Tyr Leu Ser Arg Val Phe Gln Asp Pro Lys Met Gly Thr 
                85                  90                  95      

Ala Pro Arg Met Thr Val Ala Glu Asn Leu Leu Ile Ala Lys Phe Arg 
            100                 105                 110         

Gly Glu Lys Arg Gly Leu Leu Pro Arg Arg Leu Thr Ser Tyr Lys Asp 
        115                 120                 125             

Glu Phe Gln Ala Thr Ile Glu Lys Val Gly Asn Gly Leu Glu Lys His 
    130                 135                 140                 

Leu Asn Thr Pro Ile Glu Phe Leu Ser Gly Gly Gln Arg Gln Ala Leu 
145                 150                 155                 160 

Ser Leu Leu Met Ala Thr Leu Lys Arg Pro Glu Leu Leu Leu Leu Asp 
                165                 170                 175     

Glu His Thr Ala Ala Leu Asp Pro Lys Thr Ser Val Ala Leu Met Glu 
            180                 185                 190         

Leu Thr Asp Glu Phe Val Lys Lys Asp Gln Leu Thr Ala Leu Met Ile 
        195                 200                 205             

Thr His His Met Glu Asp Ala Leu Lys Tyr Gly Asn Arg Leu Ile Val 
    210                 215                 220                 

Met Lys Glu Gly Arg Ile Ile Gln Asp Leu Asn Gln Glu Glu Lys Ala 
225                 230                 235                 240 

Lys Met Lys Ile Ser Asp Tyr Tyr Gln Leu Phe Glu 
                245                 250         

<210>   2125
<211>   1773
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2125
atggaggtat tgtgtatggt tgacaaacaa gtcattgaag aaatcaaaaa caatgccaac   60
attgtggaag tcataggaga tgtgatttct ttacaaaagg caggacggaa ctatctaggg   120
ctctgtcctt ttcatggtga aaaaacacca tctttcaatg ttgtagagga caagcagttt   180
tatcactgtt tcggttgtgg tcgctcaggt gatgtcttta agttcatcga ggagtaccaa   240
ggggttccct ttatagaagc agtccaaatc ttaggtcagc gtgttggaat tgaggttgaa   300
aaaccgcttt atagtgagca gaagtcagcc tcacctcacc aagctcttta tgatatgcac   360
gaagatgcag ccaaatttta ccatgctatt ctcatgacaa cgactatggg cgaagaggcc   420
agaaattacc tttatcagcg ggggttgaca gatgaagtgc ttaaacattt ttggattggt   480
ttagcacctc cagaacgaaa ctatctctat caacgtttgt ctgatcagta tcgtgaagag   540
gatttactgg attcaggcct gttttatctc tcggatgcca atcaatttgt agacaccttt   600
cacaatcgca ttatgtttcc cctgacaaat gaccaaggaa aggtcattgc cttctcaggt   660
cgtatctggc aaaaaacgga ttcacaaact tctaagtata aaaacagccg atcgactgca   720
atttttaaca aaagttacga attatatcat atggataggg caaaaagatc ttctggaaaa   780
gctagtgaga tttacctgat ggaaggattc atggatgtta ttgcagccta tcgggctgga   840
atcgaaaatg ctgtggcgtc gatgggaaca gccttgagtc gagagcatgt tgagcatctg   900
aaaaggttaa ccaagaaatt ggttcttgtt tacgatggag ataaggctgg gcaagccgcg   960
acattgaaag cattggatga aattggtgat atgcctgtgc aaatcgtcag catgcctgat   1020
aacttggatc ctgatgagta tctacaaaaa aatggtccag aagacttggc ctatctatta   1080
acgaaaactc gtattagtcc gattgagttc tacattcatc agtacaaacc tgaaaacagt   1140
gaaaatctgc aggctcagat tgagtttctt gaaaaaatag ctcccttgat tgttcaagaa   1200
aagtccatcg ctgctcaaaa cagctatatt catattttag ctgacagtct ggcgtccttt   1260
gattataccc agattgagca gattgttaat gagagtcgtc aggtgcaaag gcagaatcgc   1320
atggaaggaa tttccagacc gacgccaatc accatgcctg tcaccaagca gttatcggct   1380
attatgaggg cagaagccca tctactctat cggatgatgg aatcccctct tgttttgaac   1440
gattaccgtt tgcgagaaga ctttgcattt gctacacctg aatttcaggt cttatatgac   1500
ttgcttggcc agtatggaaa tcttcctcca gaagttttag cagagcagac agaggaagtt   1560
gaaagagctt ggtaccaagt tttagctcag gatttgcctg ctgagatatc gccgcaggaa   1620
cttagtgaag tagagatgac tcgaaacaag gctctcttga atcaggacaa tatgagaatc   1680
aaaaagaagg tgcaggaagc tagccatgta ggagatacag atacagccct agaagaattg   1740
gaacgtttaa tttcccaaaa gagaagaatg gag                                1773

<210>   2126
<211>   591
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA primase (dnaG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903022 (0.E+01)

<400>   2126
Met Glu Val Leu Cys Met Val Asp Lys Gln Val Ile Glu Glu Ile Lys 
1               5                   10                  15      

Asn Asn Ala Asn Ile Val Glu Val Ile Gly Asp Val Ile Ser Leu Gln 
            20                  25                  30          

Lys Ala Gly Arg Asn Tyr Leu Gly Leu Cys Pro Phe His Gly Glu Lys 
        35                  40                  45              

Thr Pro Ser Phe Asn Val Val Glu Asp Lys Gln Phe Tyr His Cys Phe 
    50                  55                  60                  

Gly Cys Gly Arg Ser Gly Asp Val Phe Lys Phe Ile Glu Glu Tyr Gln 
65                  70                  75                  80  

Gly Val Pro Phe Ile Glu Ala Val Gln Ile Leu Gly Gln Arg Val Gly 
                85                  90                  95      

Ile Glu Val Glu Lys Pro Leu Tyr Ser Glu Gln Lys Ser Ala Ser Pro 
            100                 105                 110         

His Gln Ala Leu Tyr Asp Met His Glu Asp Ala Ala Lys Phe Tyr His 
        115                 120                 125             

Ala Ile Leu Met Thr Thr Thr Met Gly Glu Glu Ala Arg Asn Tyr Leu 
    130                 135                 140                 

Tyr Gln Arg Gly Leu Thr Asp Glu Val Leu Lys His Phe Trp Ile Gly 
145                 150                 155                 160 

Leu Ala Pro Pro Glu Arg Asn Tyr Leu Tyr Gln Arg Leu Ser Asp Gln 
                165                 170                 175     

Tyr Arg Glu Glu Asp Leu Leu Asp Ser Gly Leu Phe Tyr Leu Ser Asp 
            180                 185                 190         

Ala Asn Gln Phe Val Asp Thr Phe His Asn Arg Ile Met Phe Pro Leu 
        195                 200                 205             

Thr Asn Asp Gln Gly Lys Val Ile Ala Phe Ser Gly Arg Ile Trp Gln 
    210                 215                 220                 

Lys Thr Asp Ser Gln Thr Ser Lys Tyr Lys Asn Ser Arg Ser Thr Ala 
225                 230                 235                 240 

Ile Phe Asn Lys Ser Tyr Glu Leu Tyr His Met Asp Arg Ala Lys Arg 
                245                 250                 255     

Ser Ser Gly Lys Ala Ser Glu Ile Tyr Leu Met Glu Gly Phe Met Asp 
            260                 265                 270         

Val Ile Ala Ala Tyr Arg Ala Gly Ile Glu Asn Ala Val Ala Ser Met 
        275                 280                 285             

Gly Thr Ala Leu Ser Arg Glu His Val Glu His Leu Lys Arg Leu Thr 
    290                 295                 300                 

Lys Lys Leu Val Leu Val Tyr Asp Gly Asp Lys Ala Gly Gln Ala Ala 
305                 310                 315                 320 

Thr Leu Lys Ala Leu Asp Glu Ile Gly Asp Met Pro Val Gln Ile Val 
                325                 330                 335     

Ser Met Pro Asp Asn Leu Asp Pro Asp Glu Tyr Leu Gln Lys Asn Gly 
            340                 345                 350         

Pro Glu Asp Leu Ala Tyr Leu Leu Thr Lys Thr Arg Ile Ser Pro Ile 
        355                 360                 365             

Glu Phe Tyr Ile His Gln Tyr Lys Pro Glu Asn Ser Glu Asn Leu Gln 
    370                 375                 380                 

Ala Gln Ile Glu Phe Leu Glu Lys Ile Ala Pro Leu Ile Val Gln Glu 
385                 390                 395                 400 

Lys Ser Ile Ala Ala Gln Asn Ser Tyr Ile His Ile Leu Ala Asp Ser 
                405                 410                 415     

Leu Ala Ser Phe Asp Tyr Thr Gln Ile Glu Gln Ile Val Asn Glu Ser 
            420                 425                 430         

Arg Gln Val Gln Arg Gln Asn Arg Met Glu Gly Ile Ser Arg Pro Thr 
        435                 440                 445             

Pro Ile Thr Met Pro Val Thr Lys Gln Leu Ser Ala Ile Met Arg Ala 
    450                 455                 460                 

Glu Ala His Leu Leu Tyr Arg Met Met Glu Ser Pro Leu Val Leu Asn 
465                 470                 475                 480 

Asp Tyr Arg Leu Arg Glu Asp Phe Ala Phe Ala Thr Pro Glu Phe Gln 
                485                 490                 495     

Val Leu Tyr Asp Leu Leu Gly Gln Tyr Gly Asn Leu Pro Pro Glu Val 
            500                 505                 510         

Leu Ala Glu Gln Thr Glu Glu Val Glu Arg Ala Trp Tyr Gln Val Leu 
        515                 520                 525             

Ala Gln Asp Leu Pro Ala Glu Ile Ser Pro Gln Glu Leu Ser Glu Val 
    530                 535                 540                 

Glu Met Thr Arg Asn Lys Ala Leu Leu Asn Gln Asp Asn Met Arg Ile 
545                 550                 555                 560 

Lys Lys Lys Val Gln Glu Ala Ser His Val Gly Asp Thr Asp Thr Ala 
                565                 570                 575     

Leu Glu Glu Leu Glu Arg Leu Ile Ser Gln Lys Arg Arg Met Glu 
            580                 585                 590     

<210>   2127
<211>   1107
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2127
atggcaacaa aacaaaaaga agtaacaaca tttgacgtac aggtagcaga atttatccgt   60
aatcataagc aaaaagggac agcaacagat gatgaaatca atgcaagtct ggttattcct   120
tttaccttgg acgctgatgg gattgaagat ctcttgcaac ggattcagga tgcaggcatt   180
tctatcacag ataacgaagg aaatccaagt gcgcgtgttc tcagcaatga agaagaacca   240
gaactcagcg atgaggactt gattgggtca acttctgcta aggtcaatga ccctgtccgt   300
atgtacttga aagaaatagg ggtcgttcct ctcttgacca atgaagagga gaaagagttg   360
gcactggctg ttgaagctgg tgatatcgaa gccaaacaac gtcttgcgga agccaatctt   420
cgtttggttg tttccattgc caaacgctat gtcggtcgtg gtatgcagtt ccttgacttg   480
attcaagaag gaaatatggg cttgatgaag gcggttgaca agtttgacta ttctaaaggg   540
ttcaagtttt caacttatgc aacttggtgg attcgtcagg ctatcactcg tgctattgcg   600
gaccaagctc gtaccatccg tatcccagtt cacatggttg aaactatcaa taaattggtt   660
cgtgaacagc ggaatctcct tcaagaattg gggcaagatc cgacaccaga acagattgct   720
gaacgaatgg atatgacacc tgataaggtt cgtgaaatct tgaagattgc ccaagaacca   780
gtatctcttg aaactcctat cggtgaagag gacgatagcc accttggaga ctttatcgaa   840
gatgaagtga ttgaaaatcc agtggattat acgactcgta tcgtcttgcg tgagcaattg   900
gatgaaatct tagatactct tacagaccgt gaagaaaatg ttctgcgtct acgttttgga   960
ctagatgatg gaaaaatgcg cacacttgaa gatgtgggga aagtctttaa cgtaactcgt   1020
gagcgtatcc gtcagattga agcaaaggct ttgagaaaac tacgccaacc aagtcgtagc   1080
aaaccgcttc gtgattttat tgaagac                                       1107

<210>   2128
<211>   369
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   RNA polymerase sigma-70 factor (rpoD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903023 (0.E+01)

<400>   2128
Met Ala Thr Lys Gln Lys Glu Val Thr Thr Phe Asp Val Gln Val Ala 
1               5                   10                  15      

Glu Phe Ile Arg Asn His Lys Gln Lys Gly Thr Ala Thr Asp Asp Glu 
            20                  25                  30          

Ile Asn Ala Ser Leu Val Ile Pro Phe Thr Leu Asp Ala Asp Gly Ile 
        35                  40                  45              

Glu Asp Leu Leu Gln Arg Ile Gln Asp Ala Gly Ile Ser Ile Thr Asp 
    50                  55                  60                  

Asn Glu Gly Asn Pro Ser Ala Arg Val Leu Ser Asn Glu Glu Glu Pro 
65                  70                  75                  80  

Glu Leu Ser Asp Glu Asp Leu Ile Gly Ser Thr Ser Ala Lys Val Asn 
                85                  90                  95      

Asp Pro Val Arg Met Tyr Leu Lys Glu Ile Gly Val Val Pro Leu Leu 
            100                 105                 110         

Thr Asn Glu Glu Glu Lys Glu Leu Ala Leu Ala Val Glu Ala Gly Asp 
        115                 120                 125             

Ile Glu Ala Lys Gln Arg Leu Ala Glu Ala Asn Leu Arg Leu Val Val 
    130                 135                 140                 

Ser Ile Ala Lys Arg Tyr Val Gly Arg Gly Met Gln Phe Leu Asp Leu 
145                 150                 155                 160 

Ile Gln Glu Gly Asn Met Gly Leu Met Lys Ala Val Asp Lys Phe Asp 
                165                 170                 175     

Tyr Ser Lys Gly Phe Lys Phe Ser Thr Tyr Ala Thr Trp Trp Ile Arg 
            180                 185                 190         

Gln Ala Ile Thr Arg Ala Ile Ala Asp Gln Ala Arg Thr Ile Arg Ile 
        195                 200                 205             

Pro Val His Met Val Glu Thr Ile Asn Lys Leu Val Arg Glu Gln Arg 
    210                 215                 220                 

Asn Leu Leu Gln Glu Leu Gly Gln Asp Pro Thr Pro Glu Gln Ile Ala 
225                 230                 235                 240 

Glu Arg Met Asp Met Thr Pro Asp Lys Val Arg Glu Ile Leu Lys Ile 
                245                 250                 255     

Ala Gln Glu Pro Val Ser Leu Glu Thr Pro Ile Gly Glu Glu Asp Asp 
            260                 265                 270         

Ser His Leu Gly Asp Phe Ile Glu Asp Glu Val Ile Glu Asn Pro Val 
        275                 280                 285             

Asp Tyr Thr Thr Arg Ile Val Leu Arg Glu Gln Leu Asp Glu Ile Leu 
    290                 295                 300                 

Asp Thr Leu Thr Asp Arg Glu Glu Asn Val Leu Arg Leu Arg Phe Gly 
305                 310                 315                 320 

Leu Asp Asp Gly Lys Met Arg Thr Leu Glu Asp Val Gly Lys Val Phe 
                325                 330                 335     

Asn Val Thr Arg Glu Arg Ile Arg Gln Ile Glu Ala Lys Ala Leu Arg 
            340                 345                 350         

Lys Leu Arg Gln Pro Ser Arg Ser Lys Pro Leu Arg Asp Phe Ile Glu 
        355                 360                 365             

Asp 
    

<210>   2129
<211>   327
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2129
atggcttata cagaagagca aattgaaaac atcaaaacac ggattttaac agccttggaa   60
gaagtcatcg accctgagtt gggaatcgat attgtcaatc ttggtttgat ctatgagatt   120
cgttttgacg gtgacacagg gcaaacagag attgacatga ctttgacaac tatgggttgt   180
cccttagcag accttttgac agaccagatt tatgatgcta tgatagaggt tccagaagta   240
acggatactg aggttaaatt agtctggtat ccagcctgga cagttgaaaa aatgagtcgc   300
tatgcccgca ttgccctagg cattaag                                       327

<210>   2130
<211>   109
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903024 (3.E-59)

<400>   2130
Met Ala Tyr Thr Glu Glu Gln Ile Glu Asn Ile Lys Thr Arg Ile Leu 
1               5                   10                  15      

Thr Ala Leu Glu Glu Val Ile Asp Pro Glu Leu Gly Ile Asp Ile Val 
            20                  25                  30          

Asn Leu Gly Leu Ile Tyr Glu Ile Arg Phe Asp Gly Asp Thr Gly Gln 
        35                  40                  45              

Thr Glu Ile Asp Met Thr Leu Thr Thr Met Gly Cys Pro Leu Ala Asp 
    50                  55                  60                  

Leu Leu Thr Asp Gln Ile Tyr Asp Ala Met Ile Glu Val Pro Glu Val 
65                  70                  75                  80  

Thr Asp Thr Glu Val Lys Leu Val Trp Tyr Pro Ala Trp Thr Val Glu 
                85                  90                  95      

Lys Met Ser Arg Tyr Ala Arg Ile Ala Leu Gly Ile Lys 
            100                 105                 

<210>   2131
<211>   1014
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2131
atgttgagtt caagtgagaa agtagcagga cagggagttt caggtgctta ccgtgaatta   60
gttcgtcttc ttcaccgtgc tgccaaggac caattgattg ttacagaaaa tcttccaatc   120
gaggcagatg tgactcactt tcatacgatt gattttccct attatttatc aaccttccaa   180
aagaaacgct cagggagaaa gattggctat gtgcatttct tgccagctac acttgaggga   240
agtttgaaaa ttccattttt cttaaaggga attgtgaaac gctatgtatt ttctttttac   300
aaccggatgg agcacttggt tgtggtcaat cctatgttta ttgaggattt ggtagcagct   360
ggtattccac gtgaaaaagt gacctatatt cctaactttg tcaacaagga aaaatggcat   420
cctctaccac aagaagaggt agtcagactg cgcacagatc ttggtcttag tgacaatcag   480
tttatcgtag taggtgctgg gcaagttcag aaacgtaaag ggattgatga ctttatccgt   540
ctggctgagg aattgcctca gattaccttt atctgggctg gtggcttctc ttttggtggt   600
atgacagatg gttatgaaca ctataagaaa attatggaaa atccccctaa aaatttgatt   660
tttccaggca ttgtatcgcc agagcggatg cgcgaattgt atgctctagc ggatcttttc   720
ttgttgccta gttacaatga gctctttcct atgactattt tagaagctgc gagttgtgag   780
gctcctatta tgttgcgtga tttagatctc tataaggtga ttttggaggg aaattatcgg   840
gcgacagcgg gtagagaaga gatgaaagag gctattttgg aatatcaagc aaatcctgct   900
gtcttaaaag atctcaaaga aaaggctaag aatatttcca gagagtattc tgaagagcat   960
ctgttacaaa tctggttgga cttttatgag aaacaagccg ctttagggag aaag         1014

<210>   2132
<211>   338
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase CpoA (cpoA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903025 (0.E+01)

<400>   2132
Met Leu Ser Ser Ser Glu Lys Val Ala Gly Gln Gly Val Ser Gly Ala 
1               5                   10                  15      

Tyr Arg Glu Leu Val Arg Leu Leu His Arg Ala Ala Lys Asp Gln Leu 
            20                  25                  30          

Ile Val Thr Glu Asn Leu Pro Ile Glu Ala Asp Val Thr His Phe His 
        35                  40                  45              

Thr Ile Asp Phe Pro Tyr Tyr Leu Ser Thr Phe Gln Lys Lys Arg Ser 
    50                  55                  60                  

Gly Arg Lys Ile Gly Tyr Val His Phe Leu Pro Ala Thr Leu Glu Gly 
65                  70                  75                  80  

Ser Leu Lys Ile Pro Phe Phe Leu Lys Gly Ile Val Lys Arg Tyr Val 
                85                  90                  95      

Phe Ser Phe Tyr Asn Arg Met Glu His Leu Val Val Val Asn Pro Met 
            100                 105                 110         

Phe Ile Glu Asp Leu Val Ala Ala Gly Ile Pro Arg Glu Lys Val Thr 
        115                 120                 125             

Tyr Ile Pro Asn Phe Val Asn Lys Glu Lys Trp His Pro Leu Pro Gln 
    130                 135                 140                 

Glu Glu Val Val Arg Leu Arg Thr Asp Leu Gly Leu Ser Asp Asn Gln 
145                 150                 155                 160 

Phe Ile Val Val Gly Ala Gly Gln Val Gln Lys Arg Lys Gly Ile Asp 
                165                 170                 175     

Asp Phe Ile Arg Leu Ala Glu Glu Leu Pro Gln Ile Thr Phe Ile Trp 
            180                 185                 190         

Ala Gly Gly Phe Ser Phe Gly Gly Met Thr Asp Gly Tyr Glu His Tyr 
        195                 200                 205             

Lys Lys Ile Met Glu Asn Pro Pro Lys Asn Leu Ile Phe Pro Gly Ile 
    210                 215                 220                 

Val Ser Pro Glu Arg Met Arg Glu Leu Tyr Ala Leu Ala Asp Leu Phe 
225                 230                 235                 240 

Leu Leu Pro Ser Tyr Asn Glu Leu Phe Pro Met Thr Ile Leu Glu Ala 
                245                 250                 255     


Ala Ser Cys Glu Ala Pro Ile Met Leu Arg Asp Leu Asp Leu Tyr Lys 
            260                 265                 270         

Val Ile Leu Glu Gly Asn Tyr Arg Ala Thr Ala Gly Arg Glu Glu Met 
        275                 280                 285             

Lys Glu Ala Ile Leu Glu Tyr Gln Ala Asn Pro Ala Val Leu Lys Asp 
    290                 295                 300                 

Leu Lys Glu Lys Ala Lys Asn Ile Ser Arg Glu Tyr Ser Glu Glu His 
305                 310                 315                 320 

Leu Leu Gln Ile Trp Leu Asp Phe Tyr Glu Lys Gln Ala Ala Leu Gly 
                325                 330                 335     

Arg Lys 
        

<210>   2133
<211>   1323
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2133
atgcgaattg gtttatttac agatacctat tttcctcagg tttctggtgt tgcgaccagt   60
attcgaacct tgaaaacaga acttgaaaag cagggacatg ctgtttttat ctttacgacg   120
acagataagg atgtcaatcg ctacgaagat tggcaaatta tccgcattcc aagtgttcct   180
ttctttgctt ttaaggatcg tcgctttgcc taccgaggtt ttagcaaggc acttgaaatt   240
gctaaacagt atcagctaga tattatccat actcagacag aattttctct tggcctgttg   300
gggatttgga ttgcgcgtga attgaaaatt ccagtcatcc atacctatca cacccagtat   360
gaagactatg tccattatat tgctaagggg atgttgatcc ggccgagtat ggtcaagtat   420
ctggttagag gtttcctgca tgatgtggat ggggttattt gccctagtga gattgtccgt   480
gacttgctat ctgattataa ggtcaaggtt gaaaaacggg tcattcctac tgggattgaa   540
ttagccaagt ttgagcgtcc ggaaatcaag caggaaaatt tgaaagaact gcgtagtaaa   600
ctagggattc aagatggtga aaagacgttg cttagtcttt cgagaatctc ctatgaaaaa   660
aatattcaag cagttttagc agcctttgct gatgttctga aagaggaaga caaggttaaa   720
ctggtagtag ctggggatgg cccttatctg aatgacctca aagagcaagc ccagaaccta   780
gagattcaag actcagtcat ctttacaggg atgattgctc ctagtgagac ggctctttac   840
tataaagcgg cggatttctt catttcggca tcgacaagcg aaacgcaagg tttgacctac   900
ttggaaagct tagccagtgg aacacctgtc attgctcacg gaaatcctta tttgaacaac   960
ctcatcagtg ataaaatgtt tggaaccttg tactatggag aacatgattt ggctggtgct   1020
attttggaag ccctgattgc aacaccagac atgaacgagc ataccttatc agagaaattg   1080
tatgagattt cagctgagaa ctttgggaaa cgagtgcatg agttttatct ggatgccatt   1140
atttcaaata acttccagaa agatttggct aaagatgata cggtcagtca gcgtatcttt   1200
aagacagttt tgtatcttca gcaacaggtg gttgctgtac ctgtaaaagg atctagacgc   1260
atgttgaagg cttcaaaaac acagttgatc agtatgagag actattggaa agaccatgaa   1320
gaa                                                                 1323

<210>   2134
<211>   441
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, group 1
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903026 (0.E+01)

<400>   2134
Met Arg Ile Gly Leu Phe Thr Asp Thr Tyr Phe Pro Gln Val Ser Gly 
1               5                   10                  15      

Val Ala Thr Ser Ile Arg Thr Leu Lys Thr Glu Leu Glu Lys Gln Gly 
            20                  25                  30          

His Ala Val Phe Ile Phe Thr Thr Thr Asp Lys Asp Val Asn Arg Tyr 
        35                  40                  45              

Glu Asp Trp Gln Ile Ile Arg Ile Pro Ser Val Pro Phe Phe Ala Phe 
    50                  55                  60                  

Lys Asp Arg Arg Phe Ala Tyr Arg Gly Phe Ser Lys Ala Leu Glu Ile 
65                  70                  75                  80  

Ala Lys Gln Tyr Gln Leu Asp Ile Ile His Thr Gln Thr Glu Phe Ser 
                85                  90                  95      

Leu Gly Leu Leu Gly Ile Trp Ile Ala Arg Glu Leu Lys Ile Pro Val 
            100                 105                 110         

Ile His Thr Tyr His Thr Gln Tyr Glu Asp Tyr Val His Tyr Ile Ala 
        115                 120                 125             

Lys Gly Met Leu Ile Arg Pro Ser Met Val Lys Tyr Leu Val Arg Gly 
    130                 135                 140                 

Phe Leu His Asp Val Asp Gly Val Ile Cys Pro Ser Glu Ile Val Arg 
145                 150                 155                 160 

Asp Leu Leu Ser Asp Tyr Lys Val Lys Val Glu Lys Arg Val Ile Pro 
                165                 170                 175     

Thr Gly Ile Glu Leu Ala Lys Phe Glu Arg Pro Glu Ile Lys Gln Glu 
            180                 185                 190         

Asn Leu Lys Glu Leu Arg Ser Lys Leu Gly Ile Gln Asp Gly Glu Lys 
        195                 200                 205             

Thr Leu Leu Ser Leu Ser Arg Ile Ser Tyr Glu Lys Asn Ile Gln Ala 
    210                 215                 220                 

Val Leu Ala Ala Phe Ala Asp Val Leu Lys Glu Glu Asp Lys Val Lys 
225                 230                 235                 240 

Leu Val Val Ala Gly Asp Gly Pro Tyr Leu Asn Asp Leu Lys Glu Gln 
                245                 250                 255     

Ala Gln Asn Leu Glu Ile Gln Asp Ser Val Ile Phe Thr Gly Met Ile 
            260                 265                 270         

Ala Pro Ser Glu Thr Ala Leu Tyr Tyr Lys Ala Ala Asp Phe Phe Ile 
        275                 280                 285             

Ser Ala Ser Thr Ser Glu Thr Gln Gly Leu Thr Tyr Leu Glu Ser Leu 
    290                 295                 300                 

Ala Ser Gly Thr Pro Val Ile Ala His Gly Asn Pro Tyr Leu Asn Asn 
305                 310                 315                 320 

Leu Ile Ser Asp Lys Met Phe Gly Thr Leu Tyr Tyr Gly Glu His Asp 
                325                 330                 335     

Leu Ala Gly Ala Ile Leu Glu Ala Leu Ile Ala Thr Pro Asp Met Asn 
            340                 345                 350         

Glu His Thr Leu Ser Glu Lys Leu Tyr Glu Ile Ser Ala Glu Asn Phe 
        355                 360                 365             

Gly Lys Arg Val His Glu Phe Tyr Leu Asp Ala Ile Ile Ser Asn Asn 
    370                 375                 380                 

Phe Gln Lys Asp Leu Ala Lys Asp Asp Thr Val Ser Gln Arg Ile Phe 
385                 390                 395                 400 

Lys Thr Val Leu Tyr Leu Gln Gln Gln Val Val Ala Val Pro Val Lys 
                405                 410                 415     

Gly Ser Arg Arg Met Leu Lys Ala Ser Lys Thr Gln Leu Ile Ser Met 
            420                 425                 430         

Arg Asp Tyr Trp Lys Asp His Glu Glu 
        435                 440     

<210>   2135
<211>   174
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2135
atgagaagcg gtcgtgataa aaagattgcg ggtgtttgtg ctggggtggc ccattatctg   60
gatatggatc cgactatcgt tcaagtcatt tggggtgttc ttacttgctg ttacggagct   120
ggaattgtag cttacattat tttatggatt atcgcaccag tagcaactga ctat         174

<210>   2136
<211>   58
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903027 (1.E-30)

<400>   2136
Met Arg Ser Gly Arg Asp Lys Lys Ile Ala Gly Val Cys Ala Gly Val 
1               5                   10                  15      

Ala His Tyr Leu Asp Met Asp Pro Thr Ile Val Gln Val Ile Trp Gly 
            20                  25                  30          

Val Leu Thr Cys Cys Tyr Gly Ala Gly Ile Val Ala Tyr Ile Ile Leu 
        35                  40                  45              

Trp Ile Ile Ala Pro Val Ala Thr Asp Tyr 
    50                  55              

<210>   2137
<211>   132
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2137
atggcatttg gagataatgg aaatcgtaaa aaaactatgt ttgagaaaat aaccttgttt   60
atcgtgatta tcatgctagt agcaagttta ttgggaattt ttgcaactgc aattggtgcc   120
ctcagtaatc ta                                                       132

<210>   2138
<211>   44
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   2138
Met Ala Phe Gly Asp Asn Gly Asn Arg Lys Lys Thr Met Phe Glu Lys 
1               5                   10                  15      

Ile Thr Leu Phe Ile Val Ile Ile Met Leu Val Ala Ser Leu Leu Gly 
            20                  25                  30          

Ile Phe Ala Thr Ala Ile Gly Ala Leu Ser Asn Leu 
        35                  40                  

<210>   2139
<211>   1308
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2139
atgagtatgt ttttagatac agctaagatt aaggtcaagg ctggtaatgg tggcgatggt   60
atggttgcct ttcgtcgtga aaaatatgtc cctaatggag gcccttgggg tggtgatggt   120
ggtcgtggag gcaatgtggt cttcgttgta gacgaaggac tacgtacctt gatggatttc   180
cgctacaatc gtcatttcaa ggctgattct ggtgaaaaag ggatgaccaa agggatgcat   240
ggtcgtggtg ctgaggacct tagagttcga gtaccacaag gtacgactgt tcgtgatgcg   300
gagactggca aggttttaac agatttgatt gaacatgggc aagaatttat cgttgcccac   360
ggtggtcgtg gtggacgtgg aaatattcgt ttcgcgacac caaaaaatcc tgcaccggaa   420
atctctgaaa atggagaacc aggtcaggaa cgtgagttac aattggaact aaaaatcttg   480
gcagatgtcg gtttagtagg attcccatct gtagggaagt caacactttt aagtgttatt   540
acctcagcta agcctaaaat tggtgcctac cactttacca ctattgtacc aaatttaggt   600
atggttcgca cccaatcagg tgaatccttt gcagtagccg acttgccagg tttgattgaa   660
ggggctagtc aaggtgttgg tttgggaact cagttcctcc gtcacatcga gcgtacacgt   720
gttatccttc acatcattga tatgtcagct agcgagggcc gtgatccata tgaggactac   780
ctagctatca ataaagagct ggagtcttac aatcttcgcc tcatggagcg tccacagatt   840
attgtagcta ataagatgga catgcctgag agtcaggaaa atcttgaaga ctttaagaaa   900
aaattggctg aaaattatga tgaatttgaa gagttaccag ctatcttccc aatttctgga   960
ttgaccaagc aaggtctggc aacactttta gatgctacag ctgaattgtt agacaagaca   1020
ccagaatttt tgctctacga cgagtccgat atggaagaag aagcttacta tggatttgac   1080
gaagaagaaa aagcctttga aattagtcgt gatgacgatg cgacatgggt actttctggt   1140
gaaaaactca tgaaactctt taatatgacc aactttgatc gtgatgaatc tgtcatgaaa   1200
tttgcccgtc agcttcgtgg tatgggggtt gatgaagccc ttcgtgcgcg tggagctaaa   1260
gatggggatt tggtccgcat tggtaaattt gagtttgaat ttgtagac                1308

<210>   2140
<211>   436
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP-binding protein, GTP1/Obg family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903028 (0.E+01)

<400>   2140
Met Ser Met Phe Leu Asp Thr Ala Lys Ile Lys Val Lys Ala Gly Asn 
1               5                   10                  15      

Gly Gly Asp Gly Met Val Ala Phe Arg Arg Glu Lys Tyr Val Pro Asn 
            20                  25                  30          

Gly Gly Pro Trp Gly Gly Asp Gly Gly Arg Gly Gly Asn Val Val Phe 
        35                  40                  45              

Val Val Asp Glu Gly Leu Arg Thr Leu Met Asp Phe Arg Tyr Asn Arg 
    50                  55                  60                  

His Phe Lys Ala Asp Ser Gly Glu Lys Gly Met Thr Lys Gly Met His 
65                  70                  75                  80  

Gly Arg Gly Ala Glu Asp Leu Arg Val Arg Val Pro Gln Gly Thr Thr 
                85                  90                  95      

Val Arg Asp Ala Glu Thr Gly Lys Val Leu Thr Asp Leu Ile Glu His 
            100                 105                 110         

Gly Gln Glu Phe Ile Val Ala His Gly Gly Arg Gly Gly Arg Gly Asn 
        115                 120                 125             

Ile Arg Phe Ala Thr Pro Lys Asn Pro Ala Pro Glu Ile Ser Glu Asn 
    130                 135                 140                 

Gly Glu Pro Gly Gln Glu Arg Glu Leu Gln Leu Glu Leu Lys Ile Leu 
145                 150                 155                 160 

Ala Asp Val Gly Leu Val Gly Phe Pro Ser Val Gly Lys Ser Thr Leu 
                165                 170                 175     

Leu Ser Val Ile Thr Ser Ala Lys Pro Lys Ile Gly Ala Tyr His Phe 
            180                 185                 190         

Thr Thr Ile Val Pro Asn Leu Gly Met Val Arg Thr Gln Ser Gly Glu 
        195                 200                 205             

Ser Phe Ala Val Ala Asp Leu Pro Gly Leu Ile Glu Gly Ala Ser Gln 
    210                 215                 220                 

Gly Val Gly Leu Gly Thr Gln Phe Leu Arg His Ile Glu Arg Thr Arg 
225                 230                 235                 240 

Val Ile Leu His Ile Ile Asp Met Ser Ala Ser Glu Gly Arg Asp Pro 
                245                 250                 255     

Tyr Glu Asp Tyr Leu Ala Ile Asn Lys Glu Leu Glu Ser Tyr Asn Leu 
            260                 265                 270         

Arg Leu Met Glu Arg Pro Gln Ile Ile Val Ala Asn Lys Met Asp Met 
        275                 280                 285             

Pro Glu Ser Gln Glu Asn Leu Glu Asp Phe Lys Lys Lys Leu Ala Glu 
    290                 295                 300                 

Asn Tyr Asp Glu Phe Glu Glu Leu Pro Ala Ile Phe Pro Ile Ser Gly 
305                 310                 315                 320 

Leu Thr Lys Gln Gly Leu Ala Thr Leu Leu Asp Ala Thr Ala Glu Leu 
                325                 330                 335     

Leu Asp Lys Thr Pro Glu Phe Leu Leu Tyr Asp Glu Ser Asp Met Glu 
            340                 345                 350         

Glu Glu Ala Tyr Tyr Gly Phe Asp Glu Glu Glu Lys Ala Phe Glu Ile 
        355                 360                 365             

Ser Arg Asp Asp Asp Ala Thr Trp Val Leu Ser Gly Glu Lys Leu Met 
    370                 375                 380                 

Lys Leu Phe Asn Met Thr Asn Phe Asp Arg Asp Glu Ser Val Met Lys 
385                 390                 395                 400 

Phe Ala Arg Gln Leu Arg Gly Met Gly Val Asp Glu Ala Leu Arg Ala 
                405                 410                 415     

Arg Gly Ala Lys Asp Gly Asp Leu Val Arg Ile Gly Lys Phe Glu Phe 
            420                 425                 430         

Glu Phe Val Asp 
        435     

<210>   2141
<211>   156
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2141
atgggagata aaccgatatc tttccgagat gcggatggta attttgtttc cgccgcagac   60
gtttggaatg aaaagaaatt ggaagaacta tttaatcgtc tcaatccaaa tcgtgccttg   120
agattggcac gaactaaaaa ggaaaatcca tctcag                             156

<210>   2142
<211>   52
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903029 (1.E-25)

<400>   2142
Met Gly Asp Lys Pro Ile Ser Phe Arg Asp Ala Asp Gly Asn Phe Val 
1               5                   10                  15      

Ser Ala Ala Asp Val Trp Asn Glu Lys Lys Leu Glu Glu Leu Phe Asn 
            20                  25                  30          

Arg Leu Asn Pro Asn Arg Ala Leu Arg Leu Ala Arg Thr Lys Lys Glu 
        35                  40                  45              

Asn Pro Ser Gln 
    50          

<210>   2143
<211>   123
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2143
atgaaaatca aagatcaaac taggaaacta gccgcaggtt gctcaaaaca ctgttttgag   60
gttgtagatg gaactgacgt agtcagtatc ctacacatac gacaaggcga tattgacgtg   120
att                                                                 123

<210>   2144
<211>   41
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   2144
Met Lys Ile Lys Asp Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Gly Thr Asp Val Val Ser Ile Leu His 
            20                  25                  30          

Ile Arg Gln Gly Asp Ile Asp Val Ile 
        35                  40      

<210>   2145
<211>   1257
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2145
atgagaaaaa ttgttatcaa tggtggatta ccactgcaag gtgaaatcac tattagtggt   60
gctaaaaata gtgtcgttgc cttaattcca gctattatct tggctgatga tgtggtgact   120
ttggattgcg ttccagatat ttcggatgta gccagtcttg tcgaaatcat ggaattgatg   180
ggagctactg ttaagcgtta tgacgatgta ttggagattg acccaagagg tgttcaaaat   240
attccaatgc cttatggtaa aattaacagt cttcgtgcat cttactattt ttatgggagc   300
ctcttaggcc gttttggtga agcgacagtt ggtctaccgg gaggatgtga tcttggtcct   360
cgtccgattg acttacacct taaggcgttt gaagctatgg gtgccactgc tagctacgag   420
ggagataaca tgaagttatc tgctaaagat acaggacttc atggtgcaag tatttacatg   480
gatacggtta gtgtgggagc aacgattaat acgatgattg ctgcggttaa agcaaatggt   540
cgtactatta ttgaaaatgc agcccgtgaa cctgagatta ttgatgtagc tactctcttg   600
aataatatgg gtgcccatat ccgtggggca ggaactaata tcatcattat tgatggtgtt   660
gaaagattac atgggacacg tcatcaggtg attccagacc gcattgaagc tggaacatat   720
atatctttag ctgctgcagt tggtaaagga attcgtataa ataatgttct ttacgaacac   780
ctggaagggt ttattgctaa gttggaagaa atgggagtga gaatgactgt atctgaagac   840
agcatttttg tcgaggaaca gtctaatttg aaagcaatca atattaagac agctccttac   900
ccaggctttg caactgattt gcaacaaccg cttacccctc ttttactaag agcgaatggt   960
cgtggtacaa ttgtcgatac gatttacgaa aaacgtgtaa atcatgtttt tgaactagca   1020
aagatggatg cggatatttc gacaacaaat ggtcatattt tgtacacggg tggacgtgat   1080
ttacgtgggg ccagtgttaa agcgaccgac ttaagagctg gggctgcact agtcattgct   1140
gggcttatgg ctgaaggtaa aactgaaatt accaatatcg agtttatctt acgtggttat   1200
tctgatatta tcgaaaaatt acgtaattta ggagcggata ttagacttgt tgaggat      1257

<210>   2146
<211>   419
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylglucosamine 1-carboxyvinyltransferase (murA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903033 (0.E+01)

<400>   2146
Met Arg Lys Ile Val Ile Asn Gly Gly Leu Pro Leu Gln Gly Glu Ile 
1               5                   10                  15      

Thr Ile Ser Gly Ala Lys Asn Ser Val Val Ala Leu Ile Pro Ala Ile 
            20                  25                  30          

Ile Leu Ala Asp Asp Val Val Thr Leu Asp Cys Val Pro Asp Ile Ser 
        35                  40                  45              

Asp Val Ala Ser Leu Val Glu Ile Met Glu Leu Met Gly Ala Thr Val 
    50                  55                  60                  

Lys Arg Tyr Asp Asp Val Leu Glu Ile Asp Pro Arg Gly Val Gln Asn 
65                  70                  75                  80  

Ile Pro Met Pro Tyr Gly Lys Ile Asn Ser Leu Arg Ala Ser Tyr Tyr 
                85                  90                  95      

Phe Tyr Gly Ser Leu Leu Gly Arg Phe Gly Glu Ala Thr Val Gly Leu 
            100                 105                 110         

Pro Gly Gly Cys Asp Leu Gly Pro Arg Pro Ile Asp Leu His Leu Lys 
        115                 120                 125             

Ala Phe Glu Ala Met Gly Ala Thr Ala Ser Tyr Glu Gly Asp Asn Met 
    130                 135                 140                 

Lys Leu Ser Ala Lys Asp Thr Gly Leu His Gly Ala Ser Ile Tyr Met 
145                 150                 155                 160 

Asp Thr Val Ser Val Gly Ala Thr Ile Asn Thr Met Ile Ala Ala Val 
                165                 170                 175     

Lys Ala Asn Gly Arg Thr Ile Ile Glu Asn Ala Ala Arg Glu Pro Glu 
            180                 185                 190         

Ile Ile Asp Val Ala Thr Leu Leu Asn Asn Met Gly Ala His Ile Arg 
        195                 200                 205             

Gly Ala Gly Thr Asn Ile Ile Ile Ile Asp Gly Val Glu Arg Leu His 
    210                 215                 220                 

Gly Thr Arg His Gln Val Ile Pro Asp Arg Ile Glu Ala Gly Thr Tyr 
225                 230                 235                 240 

Ile Ser Leu Ala Ala Ala Val Gly Lys Gly Ile Arg Ile Asn Asn Val 
                245                 250                 255     

Leu Tyr Glu His Leu Glu Gly Phe Ile Ala Lys Leu Glu Glu Met Gly 
            260                 265                 270         

Val Arg Met Thr Val Ser Glu Asp Ser Ile Phe Val Glu Glu Gln Ser 
        275                 280                 285             

Asn Leu Lys Ala Ile Asn Ile Lys Thr Ala Pro Tyr Pro Gly Phe Ala 
    290                 295                 300                 

Thr Asp Leu Gln Gln Pro Leu Thr Pro Leu Leu Leu Arg Ala Asn Gly 
305                 310                 315                 320 

Arg Gly Thr Ile Val Asp Thr Ile Tyr Glu Lys Arg Val Asn His Val 
                325                 330                 335     

Phe Glu Leu Ala Lys Met Asp Ala Asp Ile Ser Thr Thr Asn Gly His 
            340                 345                 350         

Ile Leu Tyr Thr Gly Gly Arg Asp Leu Arg Gly Ala Ser Val Lys Ala 
        355                 360                 365             

Thr Asp Leu Arg Ala Gly Ala Ala Leu Val Ile Ala Gly Leu Met Ala 
    370                 375                 380                 

Glu Gly Lys Thr Glu Ile Thr Asn Ile Glu Phe Ile Leu Arg Gly Tyr 
385                 390                 395                 400 

Ser Asp Ile Ile Glu Lys Leu Arg Asn Leu Gly Ala Asp Ile Arg Leu 
                405                 410                 415     

Val Glu Asp 
            

<210>   2147
<211>   549
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2147
atgaatattt ggaccaaatt agcaatgttt tctttttttg aaacggatcg cttgtatttg   60
cgtcctttct tttttagtga tagtcaggac ttccgcgaga tagcttcaaa tccagaaaat   120
cttcaattta ttttcccaac gcaggcaagt ctggaagaaa gtcaatatgc actggccaat   180
tactttatga agtccccttt gggagtgtgg gcaatttgtg accagaaaaa tcaacaaatg   240
attggttcta ttaaatttga gaagttagat gaaatcaaaa aagaagctga gcttggctat   300
tttttgagaa aagatgcttg gtcgcaagga tttatgacag aggttgttag aaaaatttgt   360
cagctttctt ttgaggaatt tggcttaaaa caattattta tcattaccca ccttgaaaat   420
aaagctagcc aaagagttgc tcttaagtct ggatttagtt tgttccgtca gtttaaggga   480
agtgatcgtt acacaagaaa aatgcgggat tatcttgaat ttcggtatgt aaaaggagag   540
ttcaatgag                                                           549

<210>   2148
<211>   183
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903034 (e-103)

<400>   2148
Met Asn Ile Trp Thr Lys Leu Ala Met Phe Ser Phe Phe Glu Thr Asp 
1               5                   10                  15      

Arg Leu Tyr Leu Arg Pro Phe Phe Phe Ser Asp Ser Gln Asp Phe Arg 
            20                  25                  30          

Glu Ile Ala Ser Asn Pro Glu Asn Leu Gln Phe Ile Phe Pro Thr Gln 
        35                  40                  45              

Ala Ser Leu Glu Glu Ser Gln Tyr Ala Leu Ala Asn Tyr Phe Met Lys 
    50                  55                  60                  

Ser Pro Leu Gly Val Trp Ala Ile Cys Asp Gln Lys Asn Gln Gln Met 
65                  70                  75                  80  

Ile Gly Ser Ile Lys Phe Glu Lys Leu Asp Glu Ile Lys Lys Glu Ala 
                85                  90                  95      

Glu Leu Gly Tyr Phe Leu Arg Lys Asp Ala Trp Ser Gln Gly Phe Met 
            100                 105                 110         

Thr Glu Val Val Arg Lys Ile Cys Gln Leu Ser Phe Glu Glu Phe Gly 
        115                 120                 125             

Leu Lys Gln Leu Phe Ile Ile Thr His Leu Glu Asn Lys Ala Ser Gln 
    130                 135                 140                 

Arg Val Ala Leu Lys Ser Gly Phe Ser Leu Phe Arg Gln Phe Lys Gly 
145                 150                 155                 160 

Ser Asp Arg Tyr Thr Arg Lys Met Arg Asp Tyr Leu Glu Phe Arg Tyr 
                165                 170                 175     

Val Lys Gly Glu Phe Asn Glu 
            180             

<210>   2149
<211>   1275
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2149
atgagtaagc atcaggaaat tctaagctat ttggaggaat taccagtagg taaaagggtc   60
agtgttcgta gcatttcgaa tcatctagga gttagtgatg gaacagccta tcgggctatt   120
aaagaagctg aaaaccgtgg aattgtggag acccgtccta gaagtggaac aattcgtgtt   180
aaatcccaga aagttgctat agagagatta acgtttgctg aaattgcaga agtgacttct   240
tctgaggttc tggctgggca agaaggttta gagagagaat ttagtaagtt ttcaattggt   300
gccatgactg aacaaaatat cttgtcttac cttcatgatg gggggctctt gattgtcgga   360
gaccgaaccc gtattcagtt gctagccttg gaaaatgaaa atgcagttct ggttacaggg   420
ggatttcagg ttcatgatga tgtgcttaaa ctggccaatc aaaaagggat tcctgttcta   480
agaagtaagc atgatacctt taccgtcgcg accatgatca ataaagcctt gtcaaatgtc   540
caaatcaaga ctgatattct gacagttgag aaactttatc gccctagtca tgagtatggt   600
tttctgagag agacagatac agttaaagat tatttggact tggttcgtaa gaatcgtagc   660
agccgtttcc ctgttatcaa tcaacatcag gtcgttgttg gtgttgtaac catgagagac   720
gctggtgata aatcaccaag cacgacaatt gataaggtta tgtctcgtag tctatttttg   780
gttggattat cgacaaatat tgccaatgtg agtcaacgga tgatcgcaga agactttgaa   840
atggtaccag ttgttcgaag caatcaaact ttgcttggcg ttgtgacgcg acgagatgtc   900
atggagaaga tgagccgttc ccaagtttcg gctctaccaa ctttttctga gcagattgga   960
caaaagctct cttatcacca tgatgaagta gtcattacag tggaaccctt tatgctagaa   1020
aaaaatggag ttttggctaa tggtgtattg gcagaaattc tgacccacat gacccaagat   1080
ttagttgtta atagtggtcg caatctcatt atcgagcaga tgctgatcta ctttttgcag   1140
gctgttcaga tagatgatat attgcgcatt caggcacgga ttattcatca tacgagacgg   1200
tcagctataa ttgattacga tatttatcat ggtcaccaga ttgtttcaaa agcaaatgtg   1260
actgttaaaa ttaat                                                    1275

<210>   2150
<211>   425
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein

<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903035 (0.E+01)

<400>   2150
Met Ser Lys His Gln Glu Ile Leu Ser Tyr Leu Glu Glu Leu Pro Val 
1               5                   10                  15      

Gly Lys Arg Val Ser Val Arg Ser Ile Ser Asn His Leu Gly Val Ser 
            20                  25                  30          

Asp Gly Thr Ala Tyr Arg Ala Ile Lys Glu Ala Glu Asn Arg Gly Ile 
        35                  40                  45              

Val Glu Thr Arg Pro Arg Ser Gly Thr Ile Arg Val Lys Ser Gln Lys 
    50                  55                  60                  

Val Ala Ile Glu Arg Leu Thr Phe Ala Glu Ile Ala Glu Val Thr Ser 
65                  70                  75                  80  

Ser Glu Val Leu Ala Gly Gln Glu Gly Leu Glu Arg Glu Phe Ser Lys 
                85                  90                  95      

Phe Ser Ile Gly Ala Met Thr Glu Gln Asn Ile Leu Ser Tyr Leu His 
            100                 105                 110         

Asp Gly Gly Leu Leu Ile Val Gly Asp Arg Thr Arg Ile Gln Leu Leu 
        115                 120                 125             

Ala Leu Glu Asn Glu Asn Ala Val Leu Val Thr Gly Gly Phe Gln Val 
    130                 135                 140                 

His Asp Asp Val Leu Lys Leu Ala Asn Gln Lys Gly Ile Pro Val Leu 
145                 150                 155                 160 

Arg Ser Lys His Asp Thr Phe Thr Val Ala Thr Met Ile Asn Lys Ala 
                165                 170                 175     

Leu Ser Asn Val Gln Ile Lys Thr Asp Ile Leu Thr Val Glu Lys Leu 
            180                 185                 190         

Tyr Arg Pro Ser His Glu Tyr Gly Phe Leu Arg Glu Thr Asp Thr Val 
        195                 200                 205             

Lys Asp Tyr Leu Asp Leu Val Arg Lys Asn Arg Ser Ser Arg Phe Pro 
    210                 215                 220                 

Val Ile Asn Gln His Gln Val Val Val Gly Val Val Thr Met Arg Asp 
225                 230                 235                 240 

Ala Gly Asp Lys Ser Pro Ser Thr Thr Ile Asp Lys Val Met Ser Arg 
                245                 250                 255     

Ser Leu Phe Leu Val Gly Leu Ser Thr Asn Ile Ala Asn Val Ser Gln 
            260                 265                 270         

Arg Met Ile Ala Glu Asp Phe Glu Met Val Pro Val Val Arg Ser Asn 
        275                 280                 285             

Gln Thr Leu Leu Gly Val Val Thr Arg Arg Asp Val Met Glu Lys Met 
    290                 295                 300                 


Ser Arg Ser Gln Val Ser Ala Leu Pro Thr Phe Ser Glu Gln Ile Gly 
305                 310                 315                 320 

Gln Lys Leu Ser Tyr His His Asp Glu Val Val Ile Thr Val Glu Pro 
                325                 330                 335     

Phe Met Leu Glu Lys Asn Gly Val Leu Ala Asn Gly Val Leu Ala Glu 
            340                 345                 350         

Ile Leu Thr His Met Thr Gln Asp Leu Val Val Asn Ser Gly Arg Asn 
        355                 360                 365             

Leu Ile Ile Glu Gln Met Leu Ile Tyr Phe Leu Gln Ala Val Gln Ile 
    370                 375                 380                 

Asp Asp Ile Leu Arg Ile Gln Ala Arg Ile Ile His His Thr Arg Arg 
385                 390                 395                 400 

Ser Ala Ile Ile Asp Tyr Asp Ile Tyr His Gly His Gln Ile Val Ser 
                405                 410                 415     

Lys Ala Asn Val Thr Val Lys Ile Asn 
            420                 425 

<210>   2151
<211>   858
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2151
atgataacat taaaatcagc tcgtgaaatc gaagctatgg acaaggctgg tgattttcta   60
gcaagtattc atataggctt acgtgatttg attaagccag gcgtagatat gtgggaagtt   120
gaagaatatg tccgccgtcg ttgtaaagaa gaaaatttcc ttccacttca gattggggtt   180
gacggtgcca tgatggacta tccttatgct acctgttgct ctcttaacga tgaagtggct   240
cacgctttcc ctcgtcatta tatcttgaaa gatggtgatt tgctcaaagt tgatatggtt   300
ttgggaggtc ccattgctaa atctgaccta aatgtctcaa aattaaactt caacaatgtt   360
gaacaaatga aaaaatacac tcagagctat tctggtggtt tagcagactc atgttgggct   420
tatgctgttg gtacaccgtc cgaagaagtc aaaaacttga tggatgtaac caaagaagct   480
atgtacaagg gtattgagca agctgttgtt ggaaatcgta tcggtgatat cggtgcggct   540
attcaagaat acgctgaaag tcgtggttac ggtgtagtgc gtgatttggt tggtcatggt   600
gttggcccaa ctatgcacga agaaccaatg gttcctaact atggtattgc aggtcgtgga   660
ctccgtcttc gtgaaggaat ggtcttaacc attgaaccaa tgatcaatac aggcgattgg   720
gaaattgata cagatatgaa aactggttgg gcgcataaga ccattgacgg tggattgtca   780
tgtcagtatg aacaccaatt tgtcattacg aaagatggac ctgttatctt gactagccaa   840
ggtgaagaag gaacttat                                                 858

<210>   2152
<211>   286
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   methionine aminopeptidase, type I (map)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903036 (e-170)

<400>   2152
Met Ile Thr Leu Lys Ser Ala Arg Glu Ile Glu Ala Met Asp Lys Ala 
1               5                   10                  15      

Gly Asp Phe Leu Ala Ser Ile His Ile Gly Leu Arg Asp Leu Ile Lys 
            20                  25                  30          

Pro Gly Val Asp Met Trp Glu Val Glu Glu Tyr Val Arg Arg Arg Cys 
        35                  40                  45              

Lys Glu Glu Asn Phe Leu Pro Leu Gln Ile Gly Val Asp Gly Ala Met 
    50                  55                  60                  

Met Asp Tyr Pro Tyr Ala Thr Cys Cys Ser Leu Asn Asp Glu Val Ala 
65                  70                  75                  80  

His Ala Phe Pro Arg His Tyr Ile Leu Lys Asp Gly Asp Leu Leu Lys 
                85                  90                  95      

Val Asp Met Val Leu Gly Gly Pro Ile Ala Lys Ser Asp Leu Asn Val 
            100                 105                 110         

Ser Lys Leu Asn Phe Asn Asn Val Glu Gln Met Lys Lys Tyr Thr Gln 
        115                 120                 125             

Ser Tyr Ser Gly Gly Leu Ala Asp Ser Cys Trp Ala Tyr Ala Val Gly 
    130                 135                 140                 

Thr Pro Ser Glu Glu Val Lys Asn Leu Met Asp Val Thr Lys Glu Ala 
145                 150                 155                 160 

Met Tyr Lys Gly Ile Glu Gln Ala Val Val Gly Asn Arg Ile Gly Asp 
                165                 170                 175     

Ile Gly Ala Ala Ile Gln Glu Tyr Ala Glu Ser Arg Gly Tyr Gly Val 
            180                 185                 190         

Val Arg Asp Leu Val Gly His Gly Val Gly Pro Thr Met His Glu Glu 
        195                 200                 205             

Pro Met Val Pro Asn Tyr Gly Ile Ala Gly Arg Gly Leu Arg Leu Arg 
    210                 215                 220                 

Glu Gly Met Val Leu Thr Ile Glu Pro Met Ile Asn Thr Gly Asp Trp 
225                 230                 235                 240 

Glu Ile Asp Thr Asp Met Lys Thr Gly Trp Ala His Lys Thr Ile Asp 
                245                 250                 255     

Gly Gly Leu Ser Cys Gln Tyr Glu His Gln Phe Val Ile Thr Lys Asp 
            260                 265                 270         

Gly Pro Val Ile Leu Thr Ser Gln Gly Glu Glu Gly Thr Tyr 
        275                 280                 285     

<210>   2153
<211>   386
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2153
atgaatgatg aagcaagtaa acaactaact gatgcacgat ttaagcgtct tgttggtgtt   60
cagcgtacca cttttgaaga gatgttagct gtattaaaaa cagcttatca acttaaacac   120
gcaaaaggtg gacgaaaacc taaattaagc ctagaagacc ttcttatgcc cactcttcaa   180
tagtgcgaga atatcgaact tatgaagaaa ttgcggctga ttttggtatt cacgaaagca   240
actttatccg tcggagccaa tgggttgaaa taactcttgt tcaaagtggt tttacggttt   300
caagaactcc tctcagttct gaggacacgg taatgattga tgcgacggaa gtaaaaatca   360
atcgccctaa aaaaacaatt agcgaa                                        386

<210>   2154
<211>   60

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA FRAMESHIFT

<400>   2154
Met Asn Asp Glu Ala Ser Lys Gln Leu Thr Asp Ala Arg Phe Lys Arg 
1               5                   10                  15      

Leu Val Gly Val Gln Arg Thr Thr Phe Glu Glu Met Leu Ala Val Leu 
            20                  25                  30          

Lys Thr Ala Tyr Gln Leu Lys His Ala Lys Gly Gly Arg Lys Pro Lys 
        35                  40                  45              

Leu Ser Leu Glu Asp Leu Leu Met Pro Thr Leu Gln 
    50                  55                  60  

<210>   2155
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2155
gtgcgagaat atcgaactta tgaagaaatt gcggctgatt ttggtattca cgaaagcaac   60
tttatccgtc ggagccaatg ggttgaaata actcttgttc aaagtggttt tacggtttca   120
agaactcctc tcagttctga ggacacggta atgattgatg cgacggaagt aaaaatcaat   180
cgccctaaaa aaacaattag cgaa                                          204

<210>   2156
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, putative, FRAMESHIFT

<400>   2156
Met Arg Glu Tyr Arg Thr Tyr Glu Glu Ile Ala Ala Asp Phe Gly Ile 
1               5                   10                  15      

His Glu Ser Asn Phe Ile Arg Arg Ser Gln Trp Val Glu Ile Thr Leu 
            20                  25                  30          

Val Gln Ser Gly Phe Thr Val Ser Arg Thr Pro Leu Ser Ser Glu Asp 
        35                  40                  45              

Thr Val Met Ile Asp Ala Thr Glu Val Lys Ile Asn Arg Pro Lys Lys 
    50                  55                  60                  

Thr Ile Ser Glu 
65              

<210>   2157
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2157
atgaaggctc aagcgattgt cacaagtcaa gggagaattg tttctttgga tatcgctgtg   60
aactatagtc atgatatgaa gttgttcaaa atgagtcgta gaaatatcga acaagctggt   120
aaaatcttgg ctgacagtgg ttatcaaggg ctcatgaaga tatatcctca agcacaaact   180
ccacgtaaat ccagcaaact caagccgcta acagctgaag ataaagccta taaccatgcg   240
ctatctaagg aaagaagcaa ggttgagaac atctttgcca aagtaaaaac gtttaaaata   300
ttttcaacaa cctatcgaaa tcatcgtaaa cgcttcggat tacgaatgaa tttgagtgct   360
ggtattatca atcatgaact aggattc                                       387

<210>   2158
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfB FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903988 (9.E-69)

<400>   2158
Met Lys Ala Gln Ala Ile Val Thr Ser Gln Gly Arg Ile Val Ser Leu 
1               5                   10                  15      

Asp Ile Ala Val Asn Tyr Ser His Asp Met Lys Leu Phe Lys Met Ser 
            20                  25                  30          

Arg Arg Asn Ile Glu Gln Ala Gly Lys Ile Leu Ala Asp Ser Gly Tyr 
        35                  40                  45              

Gln Gly Leu Met Lys Ile Tyr Pro Gln Ala Gln Thr Pro Arg Lys Ser 
    50                  55                  60                  

Ser Lys Leu Lys Pro Leu Thr Ala Glu Asp Lys Ala Tyr Asn His Ala 
65                  70                  75                  80  

Leu Ser Lys Glu Arg Ser Lys Val Glu Asn Ile Phe Ala Lys Val Lys 
                85                  90                  95      

Thr Phe Lys Ile Phe Ser Thr Thr Tyr Arg Asn His Arg Lys Arg Phe 
            100                 105                 110         

Gly Leu Arg Met Asn Leu Ser Ala Gly Ile Ile Asn His Glu Leu Gly 
        115                 120                 125             

Phe 
    

<210>   2159
<211>   2289
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2159
atgaacgcat tattaaatgg aatgaatgac cgtcaggctg aggcggtgca aacgacagaa   60
ggtcccttgc taatcatggc aggggctggt tctggaaaga ctcgtgtttt gacccaccgt   120
atcgcttatt tgattgatga aaagctggtc aatccttgga atatcttggc cattaccttt   180
accaacaagg ctgcgcgtga gatgaaagag cgtgcttata gcctcaatcc agcgactcag   240
gactgtctga ttgcgacctt ccactccatg tgtgtgcgta ttttgcgtcg cgatgcggac   300
catattggct acaatcgtaa ttttacaatt gtggatcctg gtgaacagcg aacgctcatg   360
aaacgtattc tcaaacagtt gaacttggac cctaaaaaat ggaatgaacg aactattttg   420
gggaccattt ccaatgctaa gaatgatttg attgatgatg ttgcttatgc tgcccaagct   480
ggcgatatgt atacgcaaat tgtggcccag tgttatacag cctatcaaaa agaacttcgt   540
cagtctgaat ccgttgactt tgatgatttg attatgctga ccttgcgtct ctttgatcaa   600
aatcctgatg ttttgaccta ctaccagcaa aaattccaat acatccacgt tgatgagtac   660
caagatacca accacgctca gtaccaattg gtcaaactct tggcttcccg ttttaaaaat   720
atctgtgtgg ttggggatgc ggaccagtct atctacggtt ggcgtggtgc tgatatgcag   780
aatatcttgg actttgaaaa ggattacccc aaagccaagg ttgttttgtt ggaggaaaat   840
taccgctcaa ccaaaaccat tctccaagcg gccaacgagg ttattaaaaa taataaaaat   900
cgccgtccta aaaatctctg gactcaaaac gctgatgggg agcaaatcgt ttactatcgt   960
gccgatgatg agctggatga ggctgtattt gtagccagaa ccatcgatga acttagtcgc   1020
agtcaaaact tccttcataa ggattttgca gttctctatc ggactaatgc ccagtcccgt   1080
acaattgagg aagccctgct caagtctaac attccttata ccatggttgg cggaaccaaa   1140
ttctacagcc gtaaggaaat tcgcgatatt attgcttatc tcaaccttat tgctaatttg   1200
agtgacaata ttagttttga gcgtattatc aacgagccta aacgtggaat tggtctaggt   1260
acagttgaga aaatccgtga ttttgcaaat ttgcaaaata tgtctatgct ggatgcttct   1320
gctaatatta tgttgtctgg tatcaagggt aaggcagccc aatctatctg ggattttgcc   1380
aatatgatgc ttgatttgcg ggagcagcta gaccacttaa gcattacaga gttggttgag   1440
tccgtcctag aaaaaacagg ttatgtcgat attcttaact cccaagcgac tctagaaagc   1500
aaggcacggg ttgaaaatat cgaagagttt ctttctgtta cgaagaactt tgatgacacc   1560
acggatgtga cagaagagga aactggtctg gacaaactga gtcgtttctt aaatgacttg   1620
gctttgattg ccgacacaga ttcaggtagt caggagacat cagaagtgac cttgatgacc   1680
ctgcatgctg ccaaaggtct cgaatttcca gttgtctttt tgattgggat ggaagaaaat   1740
gtctttccac ttagtcgtgc gactgaagat tcagatgaat tagaagaaga gcgccgtcta   1800
gcctatgtag gtatcacgcg tgcagagaaa attctctatc tgaccaatgc caactcacgc   1860
ttgctttttg gtcgtaccaa ttataaccgt ccgactcgtt ttattaacga aatcagttca   1920
gacttgcttg agtatcaagg tctggctcgt cctgcaaata caagctttaa ggcatcatat   1980
agcagtggta gtatttcctt tggtcaaggt atgagtttgg ctcaggctct tcaagaccgt   2040
aaacgcggtg ctgccccaaa atcaatccag tcaagcggtc ttccatttgg tcaatttaca   2100
gctggcgcaa aaccagcatc tagcgaggca aattggtcca ttggtgatat tgctctccac   2160
aagaaatggg gagagggaac cgttctggaa gtttcaggta gcggtgctag gcaggaattg   2220
aaaatcaatt tcccagaagt aggtttgaaa aaacttttag ccagtgtggc tccaattgag   2280
aaaaaaatc                                                           2289

<210>   2160
<211>   763
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent DNA helicase PcrA (pcrA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903039 (0.E+01)

<400>   2160
Met Asn Ala Leu Leu Asn Gly Met Asn Asp Arg Gln Ala Glu Ala Val 
1               5                   10                  15      

Gln Thr Thr Glu Gly Pro Leu Leu Ile Met Ala Gly Ala Gly Ser Gly 
            20                  25                  30          

Lys Thr Arg Val Leu Thr His Arg Ile Ala Tyr Leu Ile Asp Glu Lys 
        35                  40                  45              

Leu Val Asn Pro Trp Asn Ile Leu Ala Ile Thr Phe Thr Asn Lys Ala 
    50                  55                  60                  

Ala Arg Glu Met Lys Glu Arg Ala Tyr Ser Leu Asn Pro Ala Thr Gln 
65                  70                  75                  80  

Asp Cys Leu Ile Ala Thr Phe His Ser Met Cys Val Arg Ile Leu Arg 
                85                  90                  95      

Arg Asp Ala Asp His Ile Gly Tyr Asn Arg Asn Phe Thr Ile Val Asp 
            100                 105                 110         

Pro Gly Glu Gln Arg Thr Leu Met Lys Arg Ile Leu Lys Gln Leu Asn 
        115                 120                 125             

Leu Asp Pro Lys Lys Trp Asn Glu Arg Thr Ile Leu Gly Thr Ile Ser 
    130                 135                 140                 

Asn Ala Lys Asn Asp Leu Ile Asp Asp Val Ala Tyr Ala Ala Gln Ala 
145                 150                 155                 160 

Gly Asp Met Tyr Thr Gln Ile Val Ala Gln Cys Tyr Thr Ala Tyr Gln 
                165                 170                 175     

Lys Glu Leu Arg Gln Ser Glu Ser Val Asp Phe Asp Asp Leu Ile Met 
            180                 185                 190         

Leu Thr Leu Arg Leu Phe Asp Gln Asn Pro Asp Val Leu Thr Tyr Tyr 
        195                 200                 205             

Gln Gln Lys Phe Gln Tyr Ile His Val Asp Glu Tyr Gln Asp Thr Asn 
    210                 215                 220                 

His Ala Gln Tyr Gln Leu Val Lys Leu Leu Ala Ser Arg Phe Lys Asn 
225                 230                 235                 240 

Ile Cys Val Val Gly Asp Ala Asp Gln Ser Ile Tyr Gly Trp Arg Gly 
                245                 250                 255     

Ala Asp Met Gln Asn Ile Leu Asp Phe Glu Lys Asp Tyr Pro Lys Ala 
            260                 265                 270         

Lys Val Val Leu Leu Glu Glu Asn Tyr Arg Ser Thr Lys Thr Ile Leu 
        275                 280                 285             

Gln Ala Ala Asn Glu Val Ile Lys Asn Asn Lys Asn Arg Arg Pro Lys 
    290                 295                 300                 

Asn Leu Trp Thr Gln Asn Ala Asp Gly Glu Gln Ile Val Tyr Tyr Arg 
305                 310                 315                 320 

Ala Asp Asp Glu Leu Asp Glu Ala Val Phe Val Ala Arg Thr Ile Asp 
                325                 330                 335     


Glu Leu Ser Arg Ser Gln Asn Phe Leu His Lys Asp Phe Ala Val Leu 
            340                 345                 350         

Tyr Arg Thr Asn Ala Gln Ser Arg Thr Ile Glu Glu Ala Leu Leu Lys 
        355                 360                 365             

Ser Asn Ile Pro Tyr Thr Met Val Gly Gly Thr Lys Phe Tyr Ser Arg 
    370                 375                 380                 

Lys Glu Ile Arg Asp Ile Ile Ala Tyr Leu Asn Leu Ile Ala Asn Leu 
385                 390                 395                 400 

Ser Asp Asn Ile Ser Phe Glu Arg Ile Ile Asn Glu Pro Lys Arg Gly 
                405                 410                 415     

Ile Gly Leu Gly Thr Val Glu Lys Ile Arg Asp Phe Ala Asn Leu Gln 
            420                 425                 430         

Asn Met Ser Met Leu Asp Ala Ser Ala Asn Ile Met Leu Ser Gly Ile 
        435                 440                 445             

Lys Gly Lys Ala Ala Gln Ser Ile Trp Asp Phe Ala Asn Met Met Leu 
    450                 455                 460                 

Asp Leu Arg Glu Gln Leu Asp His Leu Ser Ile Thr Glu Leu Val Glu 
465                 470                 475                 480 

Ser Val Leu Glu Lys Thr Gly Tyr Val Asp Ile Leu Asn Ser Gln Ala 
                485                 490                 495     

Thr Leu Glu Ser Lys Ala Arg Val Glu Asn Ile Glu Glu Phe Leu Ser 
            500                 505                 510         

Val Thr Lys Asn Phe Asp Asp Thr Thr Asp Val Thr Glu Glu Glu Thr 
        515                 520                 525             

Gly Leu Asp Lys Leu Ser Arg Phe Leu Asn Asp Leu Ala Leu Ile Ala 
    530                 535                 540                 

Asp Thr Asp Ser Gly Ser Gln Glu Thr Ser Glu Val Thr Leu Met Thr 
545                 550                 555                 560 

Leu His Ala Ala Lys Gly Leu Glu Phe Pro Val Val Phe Leu Ile Gly 
                565                 570                 575     

Met Glu Glu Asn Val Phe Pro Leu Ser Arg Ala Thr Glu Asp Ser Asp 
            580                 585                 590         

Glu Leu Glu Glu Glu Arg Arg Leu Ala Tyr Val Gly Ile Thr Arg Ala 
        595                 600                 605             

Glu Lys Ile Leu Tyr Leu Thr Asn Ala Asn Ser Arg Leu Leu Phe Gly 
    610                 615                 620                 

Arg Thr Asn Tyr Asn Arg Pro Thr Arg Phe Ile Asn Glu Ile Ser Ser 
625                 630                 635                 640 

Asp Leu Leu Glu Tyr Gln Gly Leu Ala Arg Pro Ala Asn Thr Ser Phe 
                645                 650                 655     

Lys Ala Ser Tyr Ser Ser Gly Ser Ile Ser Phe Gly Gln Gly Met Ser 
            660                 665                 670         


Leu Ala Gln Ala Leu Gln Asp Arg Lys Arg Gly Ala Ala Pro Lys Ser 
        675                 680                 685             

Ile Gln Ser Ser Gly Leu Pro Phe Gly Gln Phe Thr Ala Gly Ala Lys 
    690                 695                 700                 

Pro Ala Ser Ser Glu Ala Asn Trp Ser Ile Gly Asp Ile Ala Leu His 
705                 710                 715                 720 

Lys Lys Trp Gly Glu Gly Thr Val Leu Glu Val Ser Gly Ser Gly Ala 
                725                 730                 735     

Arg Gln Glu Leu Lys Ile Asn Phe Pro Glu Val Gly Leu Lys Lys Leu 
            740                 745                 750         

Leu Ala Ser Val Ala Pro Ile Glu Lys Lys Ile 
        755                 760             

<210>   2161
<211>   693
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2161
gtgaggagga tttttatgta cagtatttca ttccaagaag attcactatt accaagagaa   60
aggctggcca aggaaggagt tgaagcgctt agtaaccaag agttgctagc tattttactc   120
aggacaggaa cacgtcaagc tagcgttttt gaaattgccc aaaaagtctt gaacaatctt   180
tcaagcctaa cggatttgaa aaaaatgacc ctgcaggaat tgcagagttt gtctggtatt   240
gggcgtgtta aggccataga attacaagct atgattgaac tggggcatcg tattcacaaa   300
cacgagactc ttgaaatgga aagtattctc agcagtcaaa agttggccaa gaagatgcag   360
caggaattag gggataaaaa acaagagcac ctggtggcac tctatctcaa tactcaaaat   420
caaatcatcc atcagcagac catttttatc gggtctgtaa ctcgtagtat cgctgaaccg   480
cgagagattc ttcactatgc aatcaagcat atggcgactt ctcttatctt ggtccacaat   540
catccttcag gagcggtagc gcctagccaa aatgatgatc atgtcactaa acttgttaaa   600
gaagcctgcg aattgatggg gattgttctc ttggaccatt tgattgtctc tcattctaat   660
tactttagtt atcgtgaaaa gacagattta atc                                693

<210>   2162
<211>   231
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA repair protein RadC (radC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903040 (e-123)

<400>   2162
Met Arg Arg Ile Phe Met Tyr Ser Ile Ser Phe Gln Glu Asp Ser Leu 
1               5                   10                  15      

Leu Pro Arg Glu Arg Leu Ala Lys Glu Gly Val Glu Ala Leu Ser Asn 
            20                  25                  30          

Gln Glu Leu Leu Ala Ile Leu Leu Arg Thr Gly Thr Arg Gln Ala Ser 
        35                  40                  45              

Val Phe Glu Ile Ala Gln Lys Val Leu Asn Asn Leu Ser Ser Leu Thr 
    50                  55                  60                  

Asp Leu Lys Lys Met Thr Leu Gln Glu Leu Gln Ser Leu Ser Gly Ile 
65                  70                  75                  80  

Gly Arg Val Lys Ala Ile Glu Leu Gln Ala Met Ile Glu Leu Gly His 
                85                  90                  95      

Arg Ile His Lys His Glu Thr Leu Glu Met Glu Ser Ile Leu Ser Ser 
            100                 105                 110         

Gln Lys Leu Ala Lys Lys Met Gln Gln Glu Leu Gly Asp Lys Lys Gln 
        115                 120                 125             

Glu His Leu Val Ala Leu Tyr Leu Asn Thr Gln Asn Gln Ile Ile His 
    130                 135                 140                 

Gln Gln Thr Ile Phe Ile Gly Ser Val Thr Arg Ser Ile Ala Glu Pro 
145                 150                 155                 160 

Arg Glu Ile Leu His Tyr Ala Ile Lys His Met Ala Thr Ser Leu Ile 
                165                 170                 175     

Leu Val His Asn His Pro Ser Gly Ala Val Ala Pro Ser Gln Asn Asp 
            180                 185                 190         

Asp His Val Thr Lys Leu Val Lys Glu Ala Cys Glu Leu Met Gly Ile 
        195                 200                 205             

Val Leu Leu Asp His Leu Ile Val Ser His Ser Asn Tyr Phe Ser Tyr 
    210                 215                 220                 

Arg Glu Lys Thr Asp Leu Ile 
225                 230     

<210>   2163
<211>   687
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2163
atgaaaaaac cagttattgg gattacagga aacgaaaaaa ctcatccaga tgatgacatc   60
atgatgagct acgcagcaaa aggctttgtt gaaggcgtta aagatgctgg agggattccc   120
atcatcctac cgattggtga tcaagaaatg gcctgccact atatcagttt gattgacaag   180
ctcatcttga caggtgggca aaatgtcgat ccaaaatttt atggcgaacc caaaaccatt   240
gatagtgatg actatcacct tcaaagagat atcttcgaac tggccctcat caaggaagct   300
attaaacaga aaaagcccat tttctctgtc tgccgtggta cccaactctt taacgttgcc   360
atgggtggaa ctttgtacca agatatcgaa gaccattggc aggattcttc tgttgagtac   420
acaactcaac gcttggtaac agaaccagat accgttctcc aagaaatcta tggagaaatc   480
tctcatatca actccttcca ccaccagagc atcaaggact tagcaccaaa tttaaaagtt   540
gtggctcatg atcctaaaga tggtatcatt gaggctgtca tgagtacgga tgatgtcgcc   600
tttctcggtg tccaatggca tccagaactt ctttttgaaa atcgtcccaa agataaaaaa   660
ctctttgact atgtcgttaa tgaactt                                       687

<210>   2164
<211>   229
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamine amidotransferase, class I
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903041 (e-133)

<400>   2164
Met Lys Lys Pro Val Ile Gly Ile Thr Gly Asn Glu Lys Thr His Pro 
1               5                   10                  15      

Asp Asp Asp Ile Met Met Ser Tyr Ala Ala Lys Gly Phe Val Glu Gly 
            20                  25                  30          

Val Lys Asp Ala Gly Gly Ile Pro Ile Ile Leu Pro Ile Gly Asp Gln 
        35                  40                  45              

Glu Met Ala Cys His Tyr Ile Ser Leu Ile Asp Lys Leu Ile Leu Thr 
    50                  55                  60                  

Gly Gly Gln Asn Val Asp Pro Lys Phe Tyr Gly Glu Pro Lys Thr Ile 
65                  70                  75                  80  

Asp Ser Asp Asp Tyr His Leu Gln Arg Asp Ile Phe Glu Leu Ala Leu 
                85                  90                  95      

Ile Lys Glu Ala Ile Lys Gln Lys Lys Pro Ile Phe Ser Val Cys Arg 
            100                 105                 110         

Gly Thr Gln Leu Phe Asn Val Ala Met Gly Gly Thr Leu Tyr Gln Asp 
        115                 120                 125             

Ile Glu Asp His Trp Gln Asp Ser Ser Val Glu Tyr Thr Thr Gln Arg 
    130                 135                 140                 

Leu Val Thr Glu Pro Asp Thr Val Leu Gln Glu Ile Tyr Gly Glu Ile 
145                 150                 155                 160 

Ser His Ile Asn Ser Phe His His Gln Ser Ile Lys Asp Leu Ala Pro 
                165                 170                 175     

Asn Leu Lys Val Val Ala His Asp Pro Lys Asp Gly Ile Ile Glu Ala 
            180                 185                 190         

Val Met Ser Thr Asp Asp Val Ala Phe Leu Gly Val Gln Trp His Pro 
        195                 200                 205             

Glu Leu Leu Phe Glu Asn Arg Pro Lys Asp Lys Lys Leu Phe Asp Tyr 
    210                 215                 220                 

Val Val Asn Glu Leu 
225                 

<210>   2165
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2165
gtgaaagata aacagtttgc tattccaaaa gctacagcaa aaagactctc tctctactat   60
cgaattttta agagatttca tgcagaaaag attgaacgtg ccaactctaa gcaaattgca   120
gaggctatcg gtattgattc agcgaccgta cgtcgtgatt tttcctattt tggtgaactt   180
ggtcgtcgtg gttttggcta tgatgtcaaa aaactaatga cattttttgc cgatttgctc   240
aatgacaact ctattaccaa tgtcatgctg gttggtattg gaaatatggg ccatgccctt   300
ctccactacc gcttccacga acgtaacaag atgaagatta tcatggcctt tgacctagac   360
gaccatcctg aagtcggtac ccaaactcct gacgggattc ccatttacgg gatttctcag   420
atcaaggata aaatcaagga tgctgatgtg aagactgcta tcctaactgt tcccagcgtc   480
aagtcacaag aggttgctaa tctcttggtt gatgctggtg tgaaaggaat tctcagtttt   540
tcaccagtcc atctgcattt accaaaagac gtggtcgttc agtatgtcga tttgacaagt   600
gaactccaaa ccctcctcta cttcatgcga aaagaggat                          639

<210>   2166
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903042 (e-119)

<400>   2166
Met Lys Asp Lys Gln Phe Ala Ile Pro Lys Ala Thr Ala Lys Arg Leu 
1               5                   10                  15      

Ser Leu Tyr Tyr Arg Ile Phe Lys Arg Phe His Ala Glu Lys Ile Glu 
            20                  25                  30          

Arg Ala Asn Ser Lys Gln Ile Ala Glu Ala Ile Gly Ile Asp Ser Ala 
        35                  40                  45              

Thr Val Arg Arg Asp Phe Ser Tyr Phe Gly Glu Leu Gly Arg Arg Gly 
    50                  55                  60                  

Phe Gly Tyr Asp Val Lys Lys Leu Met Thr Phe Phe Ala Asp Leu Leu 
65                  70                  75                  80  

Asn Asp Asn Ser Ile Thr Asn Val Met Leu Val Gly Ile Gly Asn Met 
                85                  90                  95      

Gly His Ala Leu Leu His Tyr Arg Phe His Glu Arg Asn Lys Met Lys 
            100                 105                 110         

Ile Ile Met Ala Phe Asp Leu Asp Asp His Pro Glu Val Gly Thr Gln 
        115                 120                 125             

Thr Pro Asp Gly Ile Pro Ile Tyr Gly Ile Ser Gln Ile Lys Asp Lys 
    130                 135                 140                 

Ile Lys Asp Ala Asp Val Lys Thr Ala Ile Leu Thr Val Pro Ser Val 
145                 150                 155                 160 

Lys Ser Gln Glu Val Ala Asn Leu Leu Val Asp Ala Gly Val Lys Gly 
                165                 170                 175     

Ile Leu Ser Phe Ser Pro Val His Leu His Leu Pro Lys Asp Val Val 
            180                 185                 190         

Val Gln Tyr Val Asp Leu Thr Ser Glu Leu Gln Thr Leu Leu Tyr Phe 
        195                 200                 205             

Met Arg Lys Glu Asp 
    210             

<210>   2167
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2167
atgcagattt tttacatcaa aactaagatt tttcttagtt ttttcttatt tttgttgatt   60
ttttcacaat gtttctataa aatagaagaa                                    90

<210>   2168
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   2168
Met Gln Ile Phe Tyr Ile Lys Thr Lys Ile Phe Leu Ser Phe Phe Leu 
1               5                   10                  15      

Phe Leu Leu Ile Phe Ser Gln Cys Phe Tyr Lys Ile Glu Glu 
            20                  25                  30  

<210>   2169
<211>   249
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2169
gtggtgtctt tacaaaatcg gaaagataga gccaaaatgt ttgaactgac ctataaggac   60
tgctatcatg tagagcgtac tctcaagtat gaggatcatg aggctctcat gttgactttg   120
tcaggatgtg taaccttacc agatacactt tatgtgactt ctctgacttt taggggcaaa   180
aaagtttatc aggggctggt cggagacctc taccgttttc tatctcatgc agatttttta   240
catcaaaac                                                           249

<210>   2170
<211>   83
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903043 (4.E-45)

<400>   2170
Met Val Ser Leu Gln Asn Arg Lys Asp Arg Ala Lys Met Phe Glu Leu 
1               5                   10                  15      

Thr Tyr Lys Asp Cys Tyr His Val Glu Arg Thr Leu Lys Tyr Glu Asp 
            20                  25                  30          

His Glu Ala Leu Met Leu Thr Leu Ser Gly Cys Val Thr Leu Pro Asp 
        35                  40                  45              

Thr Leu Tyr Val Thr Ser Leu Thr Phe Arg Gly Lys Lys Val Tyr Gln 
    50                  55                  60                  

Gly Leu Val Gly Asp Leu Tyr Arg Phe Leu Ser His Ala Asp Phe Leu 
65                  70                  75                  80  

His Gln Asn 
            

<210>   2171
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2171
atggcatttg aaaaaatcat tcagttaaaa aattgtcgtt acgattacac tcttagccct   60
tctgttaaaa aattcaccct caaagataac accttttttg aaactaaggt tggtaactat   120
gaactgactc gccttttgga aaaagtgcca aacagcggtg aaggcttcca actcaaaatc   180
atcattaaca aggaacttac aggggctaaa atcaatatca ctgacaagtt tggccttcgt   240
ctagttgata ttttcaaatc agaagaccac catattcatc aggaaaaatt ctacttcctc   300
atggatagct tggtagaacg tggtgtcttt acaaaatcgg aaaga                   345

<210>   2172
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903044 (3.E-63)

<400>   2172
Met Ala Phe Glu Lys Ile Ile Gln Leu Lys Asn Cys Arg Tyr Asp Tyr 
1               5                   10                  15      

Thr Leu Ser Pro Ser Val Lys Lys Phe Thr Leu Lys Asp Asn Thr Phe 
            20                  25                  30          

Phe Glu Thr Lys Val Gly Asn Tyr Glu Leu Thr Arg Leu Leu Glu Lys 
        35                  40                  45              

Val Pro Asn Ser Gly Glu Gly Phe Gln Leu Lys Ile Ile Ile Asn Lys 
    50                  55                  60                  

Glu Leu Thr Gly Ala Lys Ile Asn Ile Thr Asp Lys Phe Gly Leu Arg 
65                  70                  75                  80  

Leu Val Asp Ile Phe Lys Ser Glu Asp His His Ile His Gln Glu Lys 
                85                  90                  95      

Phe Tyr Phe Leu Met Asp Ser Leu Val Glu Arg Gly Val Phe Thr Lys 
            100                 105                 110         

Ser Glu Arg 
        115 

<210>   2173
<211>   1080
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2173
atgtcagcag ttgctatttc agctatgacc aaggttatgc aagaaaccca cggaaatcct   60
tctagtattc atggtcatgg tcgtcaagct ggcaaactct tgcgagaagc ccgtcaggaa   120
ctagcccagt tactaaggac aaaacctcaa catatctttt tcacttctgg tgggactgaa   180
ggcaataata ctaccatcat tggctactgt cttcgtcacc aagaacaagg aaaacatatc   240
atcacaactg ccatcgagca ccatgctgtc cttgaaacaa ttgattactt ggttcaacac   300
tttgggtttg aagcaaccat tatccagcca gaaaatcaag aaatcacagc ccagcaaatt   360
caaaaggctt tacgtgacga tacgattttg gtttctacca tgtttgtcaa taatgagaca   420
ggaaacctac tgcccatcgc tgaaattggc caaatactca agcaacaccc tgctgcctat   480
catgttgatg cagttcaggc tattggtaaa atcccaattc attcagaaga attgggcatt   540
gattttctca ctgcttctgc ccacaaattc catggtccta agggaatcgg ttttctctac   600
gcatctagca tggactttga ttcctatcta catggcggag accaggaaca gaaaaaacgt   660

gcaggaactg aaaatctgcc tgccattgta ggcatggttg cagccctaaa agaagaccta   720
gaaaaacaag aagaacattt tcaacatgta caaaatctag aaactgcctt tctggcagag   780
ctggagggca ttcagtatta cctgaataga ggaaaacatc atctccctta tgttctcaat   840
attggatttc ctggtcagaa aaatgacctc ttactccttc ggctagattt agctggaatt   900
tcaatctcta ctggctcagc ctgtactgca ggcgttgtcc aatccagcca tgttcttgaa   960
gccatgtatg gcgcaaattc agaacgcttg aaggaatccc ttcgcatcag tttgtcgcca   1020
caaaataccg ttgaagacct acaaaccctc gcaaaaacct taaaagaaat tatcggaggt   1080

<210>   2174
<211>   360
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aminotransferase, class-V
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903045 (0.E+01)

<400>   2174
Met Ser Ala Val Ala Ile Ser Ala Met Thr Lys Val Met Gln Glu Thr 
1               5                   10                  15      

His Gly Asn Pro Ser Ser Ile His Gly His Gly Arg Gln Ala Gly Lys 
            20                  25                  30          

Leu Leu Arg Glu Ala Arg Gln Glu Leu Ala Gln Leu Leu Arg Thr Lys 
        35                  40                  45              

Pro Gln His Ile Phe Phe Thr Ser Gly Gly Thr Glu Gly Asn Asn Thr 
    50                  55                  60                  

Thr Ile Ile Gly Tyr Cys Leu Arg His Gln Glu Gln Gly Lys His Ile 
65                  70                  75                  80  

Ile Thr Thr Ala Ile Glu His His Ala Val Leu Glu Thr Ile Asp Tyr 
                85                  90                  95      

Leu Val Gln His Phe Gly Phe Glu Ala Thr Ile Ile Gln Pro Glu Asn 
            100                 105                 110         

Gln Glu Ile Thr Ala Gln Gln Ile Gln Lys Ala Leu Arg Asp Asp Thr 
        115                 120                 125             

Ile Leu Val Ser Thr Met Phe Val Asn Asn Glu Thr Gly Asn Leu Leu 
    130                 135                 140                 

Pro Ile Ala Glu Ile Gly Gln Ile Leu Lys Gln His Pro Ala Ala Tyr 
145                 150                 155                 160 

His Val Asp Ala Val Gln Ala Ile Gly Lys Ile Pro Ile His Ser Glu 
                165                 170                 175     

Glu Leu Gly Ile Asp Phe Leu Thr Ala Ser Ala His Lys Phe His Gly 
            180                 185                 190         

Pro Lys Gly Ile Gly Phe Leu Tyr Ala Ser Ser Met Asp Phe Asp Ser 
        195                 200                 205             

Tyr Leu His Gly Gly Asp Gln Glu Gln Lys Lys Arg Ala Gly Thr Glu 
    210                 215                 220                 

Asn Leu Pro Ala Ile Val Gly Met Val Ala Ala Leu Lys Glu Asp Leu 
225                 230                 235                 240 

Glu Lys Gln Glu Glu His Phe Gln His Val Gln Asn Leu Glu Thr Ala 
                245                 250                 255     

Phe Leu Ala Glu Leu Glu Gly Ile Gln Tyr Tyr Leu Asn Arg Gly Lys 
            260                 265                 270         

His His Leu Pro Tyr Val Leu Asn Ile Gly Phe Pro Gly Gln Lys Asn 
        275                 280                 285             

Asp Leu Leu Leu Leu Arg Leu Asp Leu Ala Gly Ile Ser Ile Ser Thr 
    290                 295                 300                 

Gly Ser Ala Cys Thr Ala Gly Val Val Gln Ser Ser His Val Leu Glu 
305                 310                 315                 320 

Ala Met Tyr Gly Ala Asn Ser Glu Arg Leu Lys Glu Ser Leu Arg Ile 
                325                 330                 335     

Ser Leu Ser Pro Gln Asn Thr Val Glu Asp Leu Gln Thr Leu Ala Lys 
            340                 345                 350         

Thr Leu Lys Glu Ile Ile Gly Gly 
        355                 360 

<210>   2175
<211>   957
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2175
atgtcagata gaaaaaacat gaaacttttc gcactcaact ctaaccaaga gattgcacaa   60
aaaattgccc aagctgttgg tgtcccactt ggaaaactat catcacgtca attttcagac   120
ggagaaatcc aagtaaatat cgaagaaagt gtccgtggtt atgatgttta catcatccaa   180
tcaacaagtt tccctgtcaa caaccaccta atggaattgt taatcatggt cgatgcttgt   240
gtgcgtgcaa gtgcccacag tatcaacgtt gtccttccat attttggcta tgcacgtcaa   300
gaccgcattg cttgtcctcg tgagccactt acagcaaaac tagttgccaa tatgctggtt   360
aaggctggag ttgatcgtat cctgactctt gatttgcatg ccgttcaggt tcaaggtttc   420
tttgatattc cagtggataa tcttttcact gttcccctat tcgcaaaaca ttactgcgat   480
aaaggattgc ttggttcaga tgttgttgtc gttagcccta aaaattcagg tgtcaaacgt   540
gcgcgtagcc tggctgaata tcttgatgct cctatcgcca ttatcgacta ccctcaagac   600
gatgcaactc gtaacgaagg ttatattatt ggtgatgttg aaggtaagaa agctatcttg   660
attgatgata ttttaaatac aggacgtacc ttctctgaag cttctaaaat cgttgaacgt   720
gaaggagcta cagaaattta tgctgtttct agccacggtc tcttcgtcga gggagctgct   780
gagcttcttg acaatactaa tattaaagaa attcttgtga ctgattcagt agcaacaaaa   840
gaaaaaactc ctaaaaatgt atgctacatc actgctagtg agttaattgg tgatgctatc   900
gtccgtattc acgaaagaaa accagtcagc ccactctttg cctacaataa aaagaaa      957

<210>   2176
<211>   319
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribose-phosphate pyrophosphokinase (prsA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903046 (e-180)

<400>   2176
Met Ser Asp Arg Lys Asn Met Lys Leu Phe Ala Leu Asn Ser Asn Gln 
1               5                   10                  15      

Glu Ile Ala Gln Lys Ile Ala Gln Ala Val Gly Val Pro Leu Gly Lys 
            20                  25                  30          

Leu Ser Ser Arg Gln Phe Ser Asp Gly Glu Ile Gln Val Asn Ile Glu 
        35                  40                  45              

Glu Ser Val Arg Gly Tyr Asp Val Tyr Ile Ile Gln Ser Thr Ser Phe 
    50                  55                  60                  

Pro Val Asn Asn His Leu Met Glu Leu Leu Ile Met Val Asp Ala Cys 
65                  70                  75                  80  

Val Arg Ala Ser Ala His Ser Ile Asn Val Val Leu Pro Tyr Phe Gly 
                85                  90                  95      

Tyr Ala Arg Gln Asp Arg Ile Ala Cys Pro Arg Glu Pro Leu Thr Ala 
            100                 105                 110         

Lys Leu Val Ala Asn Met Leu Val Lys Ala Gly Val Asp Arg Ile Leu 
        115                 120                 125             

Thr Leu Asp Leu His Ala Val Gln Val Gln Gly Phe Phe Asp Ile Pro 
    130                 135                 140                 

Val Asp Asn Leu Phe Thr Val Pro Leu Phe Ala Lys His Tyr Cys Asp 
145                 150                 155                 160 

Lys Gly Leu Leu Gly Ser Asp Val Val Val Val Ser Pro Lys Asn Ser 
                165                 170                 175     

Gly Val Lys Arg Ala Arg Ser Leu Ala Glu Tyr Leu Asp Ala Pro Ile 
            180                 185                 190         

Ala Ile Ile Asp Tyr Pro Gln Asp Asp Ala Thr Arg Asn Glu Gly Tyr 
        195                 200                 205             

Ile Ile Gly Asp Val Glu Gly Lys Lys Ala Ile Leu Ile Asp Asp Ile 
    210                 215                 220                 

Leu Asn Thr Gly Arg Thr Phe Ser Glu Ala Ser Lys Ile Val Glu Arg 
225                 230                 235                 240 

Glu Gly Ala Thr Glu Ile Tyr Ala Val Ser Ser His Gly Leu Phe Val 
                245                 250                 255     

Glu Gly Ala Ala Glu Leu Leu Asp Asn Thr Asn Ile Lys Glu Ile Leu 
            260                 265                 270         

Val Thr Asp Ser Val Ala Thr Lys Glu Lys Thr Pro Lys Asn Val Cys 
        275                 280                 285             

Tyr Ile Thr Ala Ser Glu Leu Ile Gly Asp Ala Ile Val Arg Ile His 
    290                 295                 300                 

Glu Arg Lys Pro Val Ser Pro Leu Phe Ala Tyr Asn Lys Lys Lys 
305                 310                 315                 

<210>   2177
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2177
atgaaacatt tagaaattga attgaaaaca ctattgaaaa aagatgaata caatcgtcta   60
aaagaccagt tcacaggtgt cactcctgtt cttcaaacaa attactacat cgacacgcct   120
gattttgaac tgcgagaaaa gaaagtcgct atgcgcattc gaacctttga agactgggct   180
gagttgacac tcaaagtccc gcagagtgtt ggaaacatgg aatacaacca aaaattgcaa   240
ctaaaagatg ctgagaacta tctgagtaag gaagaacttc ctcaagggct agtactggat   300
gaattggcga aacatggtat ccaaagtaag aactggcagg ttcttggttg tctaacaacg   360
cttcgctatg aaatgaaaac agctattggt ctcatggcac tggatcagag ccgatacttt   420
gatataacag attacgaatt ggagcttgaa gtggaaaatc atgagcaagg caaacaggat   480
tttcgacaat ttttagagaa aaatcagatt tcctatcaaa aagctccttc aaaattggtt   540
cgatttgtca aaagtatgaa aaatagc                                       567

<210>   2178
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903047 (e-107)

<400>   2178
Met Lys His Leu Glu Ile Glu Leu Lys Thr Leu Leu Lys Lys Asp Glu 
1               5                   10                  15      

Tyr Asn Arg Leu Lys Asp Gln Phe Thr Gly Val Thr Pro Val Leu Gln 
            20                  25                  30          

Thr Asn Tyr Tyr Ile Asp Thr Pro Asp Phe Glu Leu Arg Glu Lys Lys 
        35                  40                  45              

Val Ala Met Arg Ile Arg Thr Phe Glu Asp Trp Ala Glu Leu Thr Leu 
    50                  55                  60                  

Lys Val Pro Gln Ser Val Gly Asn Met Glu Tyr Asn Gln Lys Leu Gln 
65                  70                  75                  80  

Leu Lys Asp Ala Glu Asn Tyr Leu Ser Lys Glu Glu Leu Pro Gln Gly 
                85                  90                  95      

Leu Val Leu Asp Glu Leu Ala Lys His Gly Ile Gln Ser Lys Asn Trp 
            100                 105                 110         

Gln Val Leu Gly Cys Leu Thr Thr Leu Arg Tyr Glu Met Lys Thr Ala 
        115                 120                 125             

Ile Gly Leu Met Ala Leu Asp Gln Ser Arg Tyr Phe Asp Ile Thr Asp 
    130                 135                 140                 

Tyr Glu Leu Glu Leu Glu Val Glu Asn His Glu Gln Gly Lys Gln Asp 
145                 150                 155                 160 

Phe Arg Gln Phe Leu Glu Lys Asn Gln Ile Ser Tyr Gln Lys Ala Pro 
                165                 170                 175     

Ser Lys Leu Val Arg Phe Val Lys Ser Met Lys Asn Ser 
            180                 185                 

<210>   2179
<211>   669
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2179
atgaccttag aatgggaaga atttctagat ccttacattc aagctgttgg tgagttaaag   60
attaaacttc gtggtattcg taagcaatat cgtaagcaaa ataagcattc tccaattgag   120
tttgtgaccg gtcgagtcaa gccaattgag agcatcaaag aaaaaatggc tcgtcgtggc   180
attacttatg cgaccttgga acacgatttg caggatattg ctggcttacg tgtgatggtt   240
cagtttgtag atgacgtcaa ggaagtagtg gatattttgc acaagcgtca ggatatgcga   300
atcatacagg agcgagatta cattactcat agaaaagcat caggctatcg ttcctatcat   360
gtggtagtag aatatacggt tgataccatc aatggagcta agactatttt ggcagaaatt   420
caaattcgta ctttggccat gaatttctgg gcaacgatag aacattctct caactacaag   480
taccaagggg atttcccaga tgagattaag aagcgactgg aaattacagc tagaatcgcc   540
catcagttgg atgaagaaat gggtgaaatt cgtgatgata tccaagaagc ccaggcactt   600
tttgatcctt tgagtagaaa attaaatgac ggtgtaggaa acagtgacga tacagatgaa   660
gaatacagg                                                           669

<210>   2180
<211>   223
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903048 (e-127)

<400>   2180
Met Thr Leu Glu Trp Glu Glu Phe Leu Asp Pro Tyr Ile Gln Ala Val 
1               5                   10                  15      

Gly Glu Leu Lys Ile Lys Leu Arg Gly Ile Arg Lys Gln Tyr Arg Lys 
            20                  25                  30          

Gln Asn Lys His Ser Pro Ile Glu Phe Val Thr Gly Arg Val Lys Pro 
        35                  40                  45              

Ile Glu Ser Ile Lys Glu Lys Met Ala Arg Arg Gly Ile Thr Tyr Ala 
    50                  55                  60                  

Thr Leu Glu His Asp Leu Gln Asp Ile Ala Gly Leu Arg Val Met Val 
65                  70                  75                  80  

Gln Phe Val Asp Asp Val Lys Glu Val Val Asp Ile Leu His Lys Arg 
                85                  90                  95      

Gln Asp Met Arg Ile Ile Gln Glu Arg Asp Tyr Ile Thr His Arg Lys 
            100                 105                 110         

Ala Ser Gly Tyr Arg Ser Tyr His Val Val Val Glu Tyr Thr Val Asp 
        115                 120                 125             

Thr Ile Asn Gly Ala Lys Thr Ile Leu Ala Glu Ile Gln Ile Arg Thr 
    130                 135                 140                 

Leu Ala Met Asn Phe Trp Ala Thr Ile Glu His Ser Leu Asn Tyr Lys 
145                 150                 155                 160 

Tyr Gln Gly Asp Phe Pro Asp Glu Ile Lys Lys Arg Leu Glu Ile Thr 
                165                 170                 175     

Ala Arg Ile Ala His Gln Leu Asp Glu Glu Met Gly Glu Ile Arg Asp 
            180                 185                 190         

Asp Ile Gln Glu Ala Gln Ala Leu Phe Asp Pro Leu Ser Arg Lys Leu 
        195                 200                 205             

Asn Asp Gly Val Gly Asn Ser Asp Asp Thr Asp Glu Glu Tyr Arg 
    210                 215                 220             

<210>   2181
<211>   816
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2181
atgaagaata caggtaaacg aattgatctg atagccaata gaaaaccgca gagtcaaagg   60
gttttgtatg aattgcgaga tcgtttgaag agaaatcagt ttatactcaa tgataccaat   120
ccggatattg tcatttccat tggcggggat ggtatgctct tgtcggcctt tcataagtac   180
gaaaatcagc ttgacaaggt ccgctttatc ggtcttcata ctggacattt gggcttctat   240
acagattatc gtgattttga gttggacaag ctagtgacta atttgcagct agatactggg   300
gcaagggttt cttaccctgt tctgaatgtg aaggtctttc ttgaaaatgg tgaagttaag   360
attttcagag cactcaacga agccagcatc cgcaggtctg atcgaaccat ggtggcagat   420
attgtaataa atggtgttcc ctttgaacgt tttcgtggag acgggctaac agtttcgaca   480
ccgactggta gtactgccta taacaagtct cttggcggtg ctgttttaca ccctaccatt   540
gaagctttgc aattaacgga aattgccagc cttaataatc gtgtctatcg aacactgggc   600
tcttccatta ttgtgcctaa gaaggataag attgaactta ttccaacaag aaacgattat   660
catactattt cggttgacaa tagcgtttat tctttccgta atattgagcg tattgagtat   720
caaatcgacc atcataagat tcactttgtc gcgactccta gccataccag tttctggaac   780
cgtgttaagg acgcctttat cggcgaggtg gatgaa                             816

<210>   2182
<211>   272
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15903049 (e-156)

<400>   2182
Met Lys Asn Thr Gly Lys Arg Ile Asp Leu Ile Ala Asn Arg Lys Pro 
1               5                   10                  15      

Gln Ser Gln Arg Val Leu Tyr Glu Leu Arg Asp Arg Leu Lys Arg Asn 
            20                  25                  30          

Gln Phe Ile Leu Asn Asp Thr Asn Pro Asp Ile Val Ile Ser Ile Gly 
        35                  40                  45              

Gly Asp Gly Met Leu Leu Ser Ala Phe His Lys Tyr Glu Asn Gln Leu 
    50                  55                  60                  

Asp Lys Val Arg Phe Ile Gly Leu His Thr Gly His Leu Gly Phe Tyr 
65                  70                  75                  80  

Thr Asp Tyr Arg Asp Phe Glu Leu Asp Lys Leu Val Thr Asn Leu Gln 
                85                  90                  95      

Leu Asp Thr Gly Ala Arg Val Ser Tyr Pro Val Leu Asn Val Lys Val 
            100                 105                 110         

Phe Leu Glu Asn Gly Glu Val Lys Ile Phe Arg Ala Leu Asn Glu Ala 
        115                 120                 125             

Ser Ile Arg Arg Ser Asp Arg Thr Met Val Ala Asp Ile Val Ile Asn 
    130                 135                 140                 

Gly Val Pro Phe Glu Arg Phe Arg Gly Asp Gly Leu Thr Val Ser Thr 
145                 150                 155                 160 

Pro Thr Gly Ser Thr Ala Tyr Asn Lys Ser Leu Gly Gly Ala Val Leu 
                165                 170                 175     

His Pro Thr Ile Glu Ala Leu Gln Leu Thr Glu Ile Ala Ser Leu Asn 
            180                 185                 190         

Asn Arg Val Tyr Arg Thr Leu Gly Ser Ser Ile Ile Val Pro Lys Lys 
        195                 200                 205             

Asp Lys Ile Glu Leu Ile Pro Thr Arg Asn Asp Tyr His Thr Ile Ser 
    210                 215                 220                 

Val Asp Asn Ser Val Tyr Ser Phe Arg Asn Ile Glu Arg Ile Glu Tyr 
225                 230                 235                 240 

Gln Ile Asp His His Lys Ile His Phe Val Ala Thr Pro Ser His Thr 
                245                 250                 255     

Ser Phe Trp Asn Arg Val Lys Asp Ala Phe Ile Gly Glu Val Asp Glu 
            260                 265                 270         


<210>   2183
<211>   894
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2183
atgaggtttg aatttatcgc agatgaacat gtcaaggtta agaccttctt aaaaaagcac   60
gaggtttcta agggattgct ggccaagatt aagtttcgag gtggagctat tctggtcaat   120
aatcaaccgc aaaatgcaac gtatctattg gacgttggag actacgttac cattgacatt   180
cccgctgaga aaggctttga aaccttggag gctattgagc ttccattaga tattctctat   240
gaggatgacc actttctagt cttgaataaa ccctatggag tggcttctat tcctagtgtc   300
aatcactcta ataccattgc caattttatc aagggttact atgtcaagca aaattatgaa   360
aatcagcagg ttcacattgt taccagacta gatagggata cttctggctt gatgctcttt   420
gccaagcacg gttatgccca tgcacgatta gacaagcagt tgcagaagaa atctatcgag   480
aaacgctact ttgctttggt taagggagat ggacatttgg agccagaagg ggaaattatt   540
gctccgattg cgcgtgatga agattccatt attaccagac gagtggctaa aggcggaaag   600
tatgcccata cttcatacaa gattgtagct tcttatggaa atattcactt ggtctatatt   660
cacctgcaca ctggtcgaac ccatcaaatc cgagtccatt tttctcatat cggttttcct   720
ttgctgggag atgatttgta tggtggtagt ctggaagatg gtattcaacg tcaggctctg   780
cattgccatt acctatcctt ttatcatcca tttttagagc aagacttgca gttagaaagt   840
cccttgccgg atgattttag taaccttatt acccagttat caactaatac tcta         894

<210>   2184
<211>   298
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal large subunit pseudouridine synthase, RluD subfamily
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903050 (e-175)

<400>   2184
Met Arg Phe Glu Phe Ile Ala Asp Glu His Val Lys Val Lys Thr Phe 
1               5                   10                  15      

Leu Lys Lys His Glu Val Ser Lys Gly Leu Leu Ala Lys Ile Lys Phe 
            20                  25                  30          

Arg Gly Gly Ala Ile Leu Val Asn Asn Gln Pro Gln Asn Ala Thr Tyr 
        35                  40                  45              

Leu Leu Asp Val Gly Asp Tyr Val Thr Ile Asp Ile Pro Ala Glu Lys 
    50                  55                  60                  

Gly Phe Glu Thr Leu Glu Ala Ile Glu Leu Pro Leu Asp Ile Leu Tyr 
65                  70                  75                  80  

Glu Asp Asp His Phe Leu Val Leu Asn Lys Pro Tyr Gly Val Ala Ser 
                85                  90                  95      

Ile Pro Ser Val Asn His Ser Asn Thr Ile Ala Asn Phe Ile Lys Gly 
            100                 105                 110         

Tyr Tyr Val Lys Gln Asn Tyr Glu Asn Gln Gln Val His Ile Val Thr 
        115                 120                 125             

Arg Leu Asp Arg Asp Thr Ser Gly Leu Met Leu Phe Ala Lys His Gly 
    130                 135                 140                 

Tyr Ala His Ala Arg Leu Asp Lys Gln Leu Gln Lys Lys Ser Ile Glu 
145                 150                 155                 160 

Lys Arg Tyr Phe Ala Leu Val Lys Gly Asp Gly His Leu Glu Pro Glu 
                165                 170                 175     

Gly Glu Ile Ile Ala Pro Ile Ala Arg Asp Glu Asp Ser Ile Ile Thr 
            180                 185                 190         

Arg Arg Val Ala Lys Gly Gly Lys Tyr Ala His Thr Ser Tyr Lys Ile 
        195                 200                 205             

Val Ala Ser Tyr Gly Asn Ile His Leu Val Tyr Ile His Leu His Thr 
    210                 215                 220                 

Gly Arg Thr His Gln Ile Arg Val His Phe Ser His Ile Gly Phe Pro 
225                 230                 235                 240 

Leu Leu Gly Asp Asp Leu Tyr Gly Gly Ser Leu Glu Asp Gly Ile Gln 
                245                 250                 255     

Arg Gln Ala Leu His Cys His Tyr Leu Ser Phe Tyr His Pro Phe Leu 
            260                 265                 270         

Glu Gln Asp Leu Gln Leu Glu Ser Pro Leu Pro Asp Asp Phe Ser Asn 
        275                 280                 285             

Leu Ile Thr Gln Leu Ser Thr Asn Thr Leu 
    290                 295             

<210>   2185
<211>   972
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2185
atggaagttt ttgaaagtct caaagccaac cttgttggta aaaatgctcg tatcgttctc   60
cctgaagggg aagagcctcg tattcttcaa gcaacaaaac gcttagtaaa agaaacagaa   120
gtgattcctg ttttgcttgg aaatcctgaa aaaattaaaa tttatcttga aattgaagga   180
atcatggatg gttatgaggt catcgaccct caacattatc ctcaatttga agaaatggtt   240
tctgccttgg tggagcgtcg caagggcaaa atgactgaag aagatgtacg caaggttttg   300
gttgaagatg tcaactactt tggtgtgatg ttggtttact tgggcttggt tgatggaatg   360
gtgtcaggag cgattcactc aacagcttca acagttcgcc cagctctaca aatcatcaaa   420
actcgtccaa atgtaactcg tacttcagga gccttcctca tggttcgtgg tacggaacgt   480
tacctatttg gagactgtgc cattaacatc aatccagatg cagaagcctt ggctgaaatt   540
gccatcaact cagcaatcac agctaagatg tttggcatcg aacctaaaat tgccatgttg   600
agctattcta ctaaaggttc agggtttggt gaaagcgttg ataaggtcgt tgaagcaact   660
aaaattgctc acgacttgcg tcctgacctt gaaatcgatg gtgagttgca atttgatgca   720
gcctttgttc ctgaaactgc agctctgaaa gctcctggaa gtacggtagc tggtcaagca   780
aatgtcttca tcttcccagg tatcgaggca ggaaatattg gttacaagat ggctgaacgc   840
ctgggtggct ttgcggctgt aggacctgtt ttgcaaggtt taaacaagcc agttaatgat   900
ctttctcgtg gatgtaatgc agatgatgtt tacaagttga ccctcatcac agcagctcaa   960
gcagttcatc aa                                                       972

<210>   2186
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate acetyltransferase (pta)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903051 (0.E+01)

<400>   2186
Met Glu Val Phe Glu Ser Leu Lys Ala Asn Leu Val Gly Lys Asn Ala 
1               5                   10                  15      

Arg Ile Val Leu Pro Glu Gly Glu Glu Pro Arg Ile Leu Gln Ala Thr 
            20                  25                  30          

Lys Arg Leu Val Lys Glu Thr Glu Val Ile Pro Val Leu Leu Gly Asn 
        35                  40                  45              

Pro Glu Lys Ile Lys Ile Tyr Leu Glu Ile Glu Gly Ile Met Asp Gly 
    50                  55                  60                  

Tyr Glu Val Ile Asp Pro Gln His Tyr Pro Gln Phe Glu Glu Met Val 
65                  70                  75                  80  

Ser Ala Leu Val Glu Arg Arg Lys Gly Lys Met Thr Glu Glu Asp Val 
                85                  90                  95      

Arg Lys Val Leu Val Glu Asp Val Asn Tyr Phe Gly Val Met Leu Val 
            100                 105                 110         

Tyr Leu Gly Leu Val Asp Gly Met Val Ser Gly Ala Ile His Ser Thr 
        115                 120                 125             

Ala Ser Thr Val Arg Pro Ala Leu Gln Ile Ile Lys Thr Arg Pro Asn 
    130                 135                 140                 

Val Thr Arg Thr Ser Gly Ala Phe Leu Met Val Arg Gly Thr Glu Arg 
145                 150                 155                 160 

Tyr Leu Phe Gly Asp Cys Ala Ile Asn Ile Asn Pro Asp Ala Glu Ala 
                165                 170                 175     

Leu Ala Glu Ile Ala Ile Asn Ser Ala Ile Thr Ala Lys Met Phe Gly 
            180                 185                 190         

Ile Glu Pro Lys Ile Ala Met Leu Ser Tyr Ser Thr Lys Gly Ser Gly 
        195                 200                 205             

Phe Gly Glu Ser Val Asp Lys Val Val Glu Ala Thr Lys Ile Ala His 
    210                 215                 220                 

Asp Leu Arg Pro Asp Leu Glu Ile Asp Gly Glu Leu Gln Phe Asp Ala 
225                 230                 235                 240 

Ala Phe Val Pro Glu Thr Ala Ala Leu Lys Ala Pro Gly Ser Thr Val 
                245                 250                 255     

Ala Gly Gln Ala Asn Val Phe Ile Phe Pro Gly Ile Glu Ala Gly Asn 
            260                 265                 270         

Ile Gly Tyr Lys Met Ala Glu Arg Leu Gly Gly Phe Ala Ala Val Gly 
        275                 280                 285             

Pro Val Leu Gln Gly Leu Asn Lys Pro Val Asn Asp Leu Ser Arg Gly 
    290                 295                 300                 

Cys Asn Ala Asp Asp Val Tyr Lys Leu Thr Leu Ile Thr Ala Ala Gln 
305                 310                 315                 320 

Ala Val His Gln 
                

<210>   2187
<211>   525
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2187
atgagtcgtg tgcgtgtcca aatcatgaat cagtttcatc gaaaatccca tgaatacaag   60
gctatcaagc gctactggaa actcattcaa caggatagcc gtaaactgag tgataagcga   120
ttttatcgtc ctatttttcg tatgcactta accaataaag agattttaaa caagcttttg   180
agctattcgg aagacttgaa acaccactat cagctctatc aactcttgct ttttcacttc   240
cagaataagg aaccagagaa atttttcgga cttattgagg acaatcttaa gcaggttcat   300
cctatttttc agactgtctt taaaaccttc ctcaaagata aagaaaagat tatcaacgcc   360
cttcaactac actattctaa cgccaaactg gaagcgacca ataatctcat caaacttatc   420
aagcgcaatg cctttggttt tcggaacttt gaaaacttca aaaaacggat ttttatcgct   480
ctgaatatca aaaaagaaag gatgaaattt gtcctttctc gagct                   525

<210>   2188
<211>   175
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   2188
Met Ser Arg Val Arg Val Gln Ile Met Asn Gln Phe His Arg Lys Ser 
1               5                   10                  15      

His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile Gln Gln Asp 
            20                  25                  30          

Ser Arg Lys Leu Ser Asp Lys Arg Phe Tyr Arg Pro Ile Phe Arg Met 
        35                  40                  45              

His Leu Thr Asn Lys Glu Ile Leu Asn Lys Leu Leu Ser Tyr Ser Glu 
    50                  55                  60                  

Asp Leu Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu Phe His Phe 
65                  70                  75                  80  

Gln Asn Lys Glu Pro Glu Lys Phe Phe Gly Leu Ile Glu Asp Asn Leu 
                85                  90                  95      

Lys Gln Val His Pro Ile Phe Gln Thr Val Phe Lys Thr Phe Leu Lys 
            100                 105                 110         

Asp Lys Glu Lys Ile Ile Asn Ala Leu Gln Leu His Tyr Ser Asn Ala 
        115                 120                 125             

Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys Arg Asn Ala 
    130                 135                 140                 

Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile Phe Ile Ala 
145                 150                 155                 160 

Leu Asn Ile Lys Lys Glu Arg Met Lys Phe Val Leu Ser Arg Ala 
                165                 170                 175 

<210>   2189
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2189
atgagcttta ttgcgcaaga ttttaacaat ctcaatatca tcactgttct tgaaggtaga   60
acacaagctg tcatccgaga tcactttctt aaatatgata gagccgtccg atgtcgcgtc   120
aaaatcatta ctatggatat gtttagccct tactatgact tggctaaaca gcttcgcttt   180
caaatttcta ggctcaggct gaaacagtct cccaggctgt ttcactcccg aatgctaaaa   240
tcgttcttga tcgctttcac attgtacaac atcttagccg tgcta                   285

<210>   2190
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase-related

<400>   2190
Met Ser Phe Ile Ala Gln Asp Phe Asn Asn Leu Asn Ile Ile Thr Val 
1               5                   10                  15      

Leu Glu Gly Arg Thr Gln Ala Val Ile Arg Asp His Phe Leu Lys Tyr 
            20                  25                  30          

Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile Thr Met Asp Met Phe 
        35                  40                  45              

Ser Pro Tyr Tyr Asp Leu Ala Lys Gln Leu Arg Phe Gln Ile Ser Arg 
    50                  55                  60                  

Leu Arg Leu Lys Gln Ser Pro Arg Leu Phe His Ser Arg Met Leu Lys 
65                  70                  75                  80  

Ser Phe Leu Ile Ala Phe Thr Leu Tyr Asn Ile Leu Ala Val Leu 
                85                  90                  95  

<210>   2191
<211>   1324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2191
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatcg tcaataagga tacacacaag gaaatcatcg ccaaactgga ctatgaagct   120
ccatcttgtc ctgagtgcgg aagtcaaatg aagaaatatg actttcaaaa accttctaaa   180
attccttatc ttgaaacaac tggtatgcct actagaattc tccttagaaa gcgtcgtttc   240
aagtgctatc attgttctaa aattatggtt gctgaaactt ctatcgtcaa gaagaatcat   300
caaatccctc gtatcatcaa ccaaaagatt gctcaaaagt taattgaaaa gatttctatg   360
actgatattg cccatcagct ttccatctca acttcaactg tcattcgaaa gctcaatgac   420
ttccactttg agtgtaattt tagaaatctg cctaagatta tgtcttggga cgttgaaaca   480
gtccggggag tgactgtttc aatcgggaga tggagatgag ctttattgcg caagatttta   540
acaatctcaa tatcatcact gttcttgaag gtagaacaca agctgtcatc cgagatcact   600
ttcttaaata tgatagagcc gtccgatgtc gcgtcaaaat cattactatg gatatgttta   660
gcccttacta tgacttggct aaacagcttc gctttcaaat ttctaggctc aggctgaaac   720
agtctcccag gctgtttcac tcccgaatgc taaaatcgtt cttgatcgct ttcacattgt   780
acaacatctt agccgtgcta tgagtcgtgt gcgtgtccaa atcatgaatc agtttcatcg   840
aaaatcccat gaatacaagg ctatcaagcg ctactggaaa ctcattcaac aggatagccg   900
taaactgagt gataagcgat tttatcgtcc tatttttcgt atgcacttaa ccaataaaga   960
gattttaaac aagcttttga gctattcgga agacttgaaa caccactatc agctctatca   1020
actcttgctt tttcacttcc agaataagga accagagaaa tttttcggac ttattgagga   1080
caatcttaag caggttcatc ctatttttca gactgtcttt aaaaccttcc tcaaagataa   1140
agaaaagatt atcaacgccc ttcaactaca ctattctaac gccaaactgg aagcgaccaa   1200
taatctcatc aaacttatca agcgcaatgc ctttggtttt cggaactttg aaaacttcaa   1260
aaaacggatt tttatcgctc tgaatatcaa aaaagaaagg atgaaatttg tcctttctcg   1320
agct                                                                1324

<210>   2192
<211>   172
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase FRAMESHIFT

<400>   2192
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Val Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Glu Ala Pro Ser Cys Pro Glu Cys Gly Ser 
        35                  40                  45              

Gln Met Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Ile Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ser 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Glu 
    130                 135                 140                 

Cys Asn Phe Arg Asn Leu Pro Lys Ile Met Ser Trp Asp Val Glu Thr 
145                 150                 155                 160 

Val Arg Gly Val Thr Val Ser Ile Gly Arg Trp Arg 
                165                 170         

<210>   2193
<211>   288
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2193
atgcaaaaca tgatgcgtca agcacaaaaa cttcaaaaac aaatggaaca aagccaagct   60
gaacttgctg ctatgcaatt tgttggcaaa tctgctcaag atcttgtcca agcgacctta   120
actggcgata agaaagttgt cagcattgat ttcaatccag ctgtcgttga cccagaggac   180
cttgagactc tttctgatat gaccgttcaa gccatcaact ctgctcttga acaaatcgat   240
gaaactacca agaaaaaact gggtgctttc gctgggaaat tacctttc                288

<210>   2194
<211>   96
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein TIGR00103
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903054 (4.E-49)

<400>   2194
Met Gln Asn Met Met Arg Gln Ala Gln Lys Leu Gln Lys Gln Met Glu 
1               5                   10                  15      

Gln Ser Gln Ala Glu Leu Ala Ala Met Gln Phe Val Gly Lys Ser Ala 
            20                  25                  30          

Gln Asp Leu Val Gln Ala Thr Leu Thr Gly Asp Lys Lys Val Val Ser 
        35                  40                  45              

Ile Asp Phe Asn Pro Ala Val Val Asp Pro Glu Asp Leu Glu Thr Leu 
    50                  55                  60                  

Ser Asp Met Thr Val Gln Ala Ile Asn Ser Ala Leu Glu Gln Ile Asp 
65                  70                  75                  80  

Glu Thr Thr Lys Lys Lys Leu Gly Ala Phe Ala Gly Lys Leu Pro Phe 
                85                  90                  95      


<210>   2195
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2195
ttgggcttga tggctatgct actaataaca attaggagag aaaatcaggc acttgttaac   60
aacaaggatt atccccttga gatgaaagga actttagaaa tctta                   105

<210>   2196
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2196
Met Gly Leu Met Ala Met Leu Leu Ile Thr Ile Arg Arg Glu Asn Gln 
1               5                   10                  15      

Ala Leu Val Asn Asn Lys Asp Tyr Pro Leu Glu Met Lys Gly Thr Leu 
            20                  25                  30          

Glu Ile Leu 
        35  

<210>   2197
<211>   702
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2197
atgggaggta aaatgaggtt attacctata agaaaaatat cacgtcagtc taaaaggtta   60
gcactttttt tgacgttttg tgctggatat gtggatgctt acacttttat tgttcgcggg   120
aatacccttg tagctggaca aactggaaat gttgtctttc tttcagtaga attaattaaa   180
aataatgttt cggatgttag ggacaaggtt ctcaccttgc tagcgtttat gatgggagtc   240
tttttattaa cgatttataa ggaaaaattg agaattgtga aaaaacctat tctgtccttg   300
attcccttgg caatcttatc aatcattatt gcttttgtgc cgcaaactgt ggataatatc   360
tatctagtgc cgcccttggc cttctgtatg ggactggtga caactgcttt tggagaagtg   420
tcgggtattg cctataataa cgcttttatg acagggaata tcaaacggac catgctggct   480
tttggagatt atttccgaac caagcacact ccttttttgc gtgaaggatt catatttgtt   540
agcctgctta gtagttttgt ccttggcgtt gtcttttcag cctatttgac gattttctat   600
catgaaaaga ccattcttgg tgttcctatt atgatgagcg ttttttacct cagcatgctt   660
tttgcctctt ggcagaaaaa agtaaaagaa aaagcttcat tt                      702

<210>   2198
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903055 (e-130)


<400>   2198
Met Gly Gly Lys Met Arg Leu Leu Pro Ile Arg Lys Ile Ser Arg Gln 
1               5                   10                  15      

Ser Lys Arg Leu Ala Leu Phe Leu Thr Phe Cys Ala Gly Tyr Val Asp 
            20                  25                  30          

Ala Tyr Thr Phe Ile Val Arg Gly Asn Thr Leu Val Ala Gly Gln Thr 
        35                  40                  45              

Gly Asn Val Val Phe Leu Ser Val Glu Leu Ile Lys Asn Asn Val Ser 
    50                  55                  60                  

Asp Val Arg Asp Lys Val Leu Thr Leu Leu Ala Phe Met Met Gly Val 
65                  70                  75                  80  

Phe Leu Leu Thr Ile Tyr Lys Glu Lys Leu Arg Ile Val Lys Lys Pro 
                85                  90                  95      

Ile Leu Ser Leu Ile Pro Leu Ala Ile Leu Ser Ile Ile Ile Ala Phe 
            100                 105                 110         

Val Pro Gln Thr Val Asp Asn Ile Tyr Leu Val Pro Pro Leu Ala Phe 
        115                 120                 125             

Cys Met Gly Leu Val Thr Thr Ala Phe Gly Glu Val Ser Gly Ile Ala 
    130                 135                 140                 

Tyr Asn Asn Ala Phe Met Thr Gly Asn Ile Lys Arg Thr Met Leu Ala 
145                 150                 155                 160 

Phe Gly Asp Tyr Phe Arg Thr Lys His Thr Pro Phe Leu Arg Glu Gly 
                165                 170                 175     

Phe Ile Phe Val Ser Leu Leu Ser Ser Phe Val Leu Gly Val Val Phe 
            180                 185                 190         

Ser Ala Tyr Leu Thr Ile Phe Tyr His Glu Lys Thr Ile Leu Gly Val 
        195                 200                 205             

Pro Ile Met Met Ser Val Phe Tyr Leu Ser Met Leu Phe Ala Ser Trp 
    210                 215                 220                 

Gln Lys Lys Val Lys Glu Lys Ala Ser Phe 
225                 230                 

<210>   2199
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2199
gtggttcgtc ccacgatgct aggcgagtct tcacaaaaaa tcggggaaac ccataaaaat   60
cataggaggt gcataatgag cacatacgca attatcaaaa ctggcggaaa acaagttaaa   120
gttgaagttg gtcaagcagt ttacgttgaa aaattgaacg ttgaagctgg tcaagaagtt   180
acttttaacg aagttgttct tgttggtggt gaaaacactg ttgtcggaac tccacttgtt   240
gctggagcta ctgtagttgg aactgttgaa aaacaaggaa aacaaaagaa agtggttact   300
tacaagtaca aacctaaaaa aggtagccac cgtaaacaag gtcaccgtca accatataca   360
aaagttgtca tcaacgcaat caacgct                                       387

<210>   2200
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L21 (rplU)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903056 (2.E-55)

<400>   2200
Met Val Arg Pro Thr Met Leu Gly Glu Ser Ser Gln Lys Ile Gly Glu 
1               5                   10                  15      

Thr His Lys Asn His Arg Arg Cys Ile Met Ser Thr Tyr Ala Ile Ile 
            20                  25                  30          

Lys Thr Gly Gly Lys Gln Val Lys Val Glu Val Gly Gln Ala Val Tyr 
        35                  40                  45              

Val Glu Lys Leu Asn Val Glu Ala Gly Gln Glu Val Thr Phe Asn Glu 
    50                  55                  60                  

Val Val Leu Val Gly Gly Glu Asn Thr Val Val Gly Thr Pro Leu Val 
65                  70                  75                  80  

Ala Gly Ala Thr Val Val Gly Thr Val Glu Lys Gln Gly Lys Gln Lys 
                85                  90                  95      

Lys Val Val Thr Tyr Lys Tyr Lys Pro Lys Lys Gly Ser His Arg Lys 
            100                 105                 110         

Gln Gly His Arg Gln Pro Tyr Thr Lys Val Val Ile Asn Ala Ile Asn 
        115                 120                 125             

Ala 
    

<210>   2201
<211>   342
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2201
atgatacagg cagtctttga gagagccgaa gatggcgagc tgaggagtgc ggaaattact   60
ggacacgccg agagtggcga atacggctta gatgtcgtgt gtgcatcggt ttctacgctt   120
gccattaact ttatcaattc tattgagaaa tttgcaggct atgaaccaat cctagaatta   180
aacgaagatg aaggtggcta tctgatggtt gaaataccaa aagatcttcc ttcacaccag   240
agagaaatga cccagttatt ctttgaatca tttttcttag gtatggcaaa cttatcggag   300
aactattctg agttcgtcca aaccagagtt atcacagaaa ac                      342

<210>   2202
<211>   114
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903057 (2.E-60)

<400>   2202
Met Ile Gln Ala Val Phe Glu Arg Ala Glu Asp Gly Glu Leu Arg Ser 
1               5                   10                  15      

Ala Glu Ile Thr Gly His Ala Glu Ser Gly Glu Tyr Gly Leu Asp Val 
            20                  25                  30          

Val Cys Ala Ser Val Ser Thr Leu Ala Ile Asn Phe Ile Asn Ser Ile 
        35                  40                  45              

Glu Lys Phe Ala Gly Tyr Glu Pro Ile Leu Glu Leu Asn Glu Asp Glu 
    50                  55                  60                  

Gly Gly Tyr Leu Met Val Glu Ile Pro Lys Asp Leu Pro Ser His Gln 
65                  70                  75                  80  

Arg Glu Met Thr Gln Leu Phe Phe Glu Ser Phe Phe Leu Gly Met Ala 
                85                  90                  95      

Asn Leu Ser Glu Asn Tyr Ser Glu Phe Val Gln Thr Arg Val Ile Thr 
            100                 105                 110         

Glu Asn 
        

<210>   2203
<211>   291
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2203
atgttaaaaa tgactcttaa caacttgcaa cttttcgccc acaaaaaagg tggaggttct   60
acatcaaacg gacgtgattc acaagcaaaa cgtcttggag ctaaagcagc tgacggacaa   120
actgtaacag gtggatcaat cctttaccgt caacgtggta cacacatcta tccaggtgta   180
aacgttggtc gtggtggaga tgatactttg ttcgctaaag ttgaaggcgt agtacgcttt   240
gaacgtaaag gacgcgataa aaaacaagtt tctgtttacc caatcgctaa a            291

<210>   2204
<211>   97
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L27 (rpmA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903058 (2.E-47)

<400>   2204
Met Leu Lys Met Thr Leu Asn Asn Leu Gln Leu Phe Ala His Lys Lys 
1               5                   10                  15      

Gly Gly Gly Ser Thr Ser Asn Gly Arg Asp Ser Gln Ala Lys Arg Leu 
            20                  25                  30          

Gly Ala Lys Ala Ala Asp Gly Gln Thr Val Thr Gly Gly Ser Ile Leu 
        35                  40                  45              

Tyr Arg Gln Arg Gly Thr His Ile Tyr Pro Gly Val Asn Val Gly Arg 
    50                  55                  60                  

Gly Gly Asp Asp Thr Leu Phe Ala Lys Val Glu Gly Val Val Arg Phe 
65                  70                  75                  80  

Glu Arg Lys Gly Arg Asp Lys Lys Gln Val Ser Val Tyr Pro Ile Ala 
                85                  90                  95      

Lys 
    

<210>   2205
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2205
atgactgctt tccaacaact cccatctagt gtgcttcaga ctgggctatt tttctctcca   60
tctgttagct tggattctca gaccgtttca gctaaagaat atcttttccc ttatcagaag   120
gaacggctca agccattcag acaagtgaag ggacgacaag ccaatatt                168

<210>   2206
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Similar to strain R6 sequence 15903059 (2.E-27)

<400>   2206
Met Thr Ala Phe Gln Gln Leu Pro Ser Ser Val Leu Gln Thr Gly Leu 
1               5                   10                  15      

Phe Phe Ser Pro Ser Val Ser Leu Asp Ser Gln Thr Val Ser Ala Lys 
            20                  25                  30          

Glu Tyr Leu Phe Pro Tyr Gln Lys Glu Arg Leu Lys Pro Phe Arg Gln 
        35                  40                  45              

Val Lys Gly Arg Gln Ala Asn Ile 
    50                  55      

<210>   2207
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2207
atgtttgaag aatttcctaa actccctgat ttgaagcaag tcactttccc taatgacaaa   60
gaaaaaagcc aaaacagcaa agaaaaacta gatgactgct ttccaacaac tcccatc      117

<210>   2208
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2208
Met Phe Glu Glu Phe Pro Lys Leu Pro Asp Leu Lys Gln Val Thr Phe 
1               5                   10                  15      

Pro Asn Asp Lys Glu Lys Ser Gln Asn Ser Lys Glu Lys Leu Asp Asp 
            20                  25                  30          

Cys Phe Pro Thr Thr Pro Ile 
        35                  

<210>   2209
<211>   915
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2209
atgattatta ctattcctat aaaaaaccaa aaagatattg gcacaccatc tgattcagtc   60
gttgttctcg gctattttga tggcatacat aaggggcatc aagaattatt tcgtgttgcc   120
aacaaggctg cgagaaagga tttgttgcct atcgtcgtta tgacctttaa tgaatctcca   180
aagatcgctt tagagcctta tcatccagat ttgtttttgc atattttgaa ccctgctgaa   240
cgtgaaagaa aattaaagcg cgaaggtgta gaagaattat atctccttga ttttagtagt   300
caattcgcta gtctcactgc acaagaattc tttgcaactt atatcaaggc tatgaatgcc   360
aaaattattg ttgcaggttt tgattataca tttggttctg acaaaaaaac agcagaagat   420
ttaaagaatt actttgatgg agaagttatc attgttccac ctgtagaaga tgagaaagga   480
aagattagtt caactcgtat ccgtcaagct attttagatg gaaatgtgaa agaagcagga   540
aaacttttgg gggcaccgct tccatcaaga ggtatggtgg ttcatggtaa tgctcgtggt   600
cgtacaattg gttatccgac agcgaattta gtgcttttag accgtactta tatgccagca   660
gatggcgttt atgttgttga tgttgagatt caaagacaga agtatcgtgc tatggctagt   720
gtcgggaaaa atgtgacctt tgatggagaa gaagcacgtt ttgaagtcaa tatttttgat   780
tttaatcaag atatttatgg ggaaaccgtc atggtttatt ggcttgatcg cattcgagat   840
atgaccaaat ttgactcagt tgaccaatta gtggatcagt taaaggctga tgaagaagta   900
actcggaatt ggtct                                                    915

<210>   2210
<211>   305
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   macrolide-efflux protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903061 (e-175)

<400>   2210
Met Ile Ile Thr Ile Pro Ile Lys Asn Gln Lys Asp Ile Gly Thr Pro 
1               5                   10                  15      

Ser Asp Ser Val Val Val Leu Gly Tyr Phe Asp Gly Ile His Lys Gly 
            20                  25                  30          

His Gln Glu Leu Phe Arg Val Ala Asn Lys Ala Ala Arg Lys Asp Leu 
        35                  40                  45              

Leu Pro Ile Val Val Met Thr Phe Asn Glu Ser Pro Lys Ile Ala Leu 
    50                  55                  60                  

Glu Pro Tyr His Pro Asp Leu Phe Leu His Ile Leu Asn Pro Ala Glu 
65                  70                  75                  80  

Arg Glu Arg Lys Leu Lys Arg Glu Gly Val Glu Glu Leu Tyr Leu Leu 
                85                  90                  95      

Asp Phe Ser Ser Gln Phe Ala Ser Leu Thr Ala Gln Glu Phe Phe Ala 
            100                 105                 110         

Thr Tyr Ile Lys Ala Met Asn Ala Lys Ile Ile Val Ala Gly Phe Asp 
        115                 120                 125             

Tyr Thr Phe Gly Ser Asp Lys Lys Thr Ala Glu Asp Leu Lys Asn Tyr 
    130                 135                 140                 

Phe Asp Gly Glu Val Ile Ile Val Pro Pro Val Glu Asp Glu Lys Gly 
145                 150                 155                 160 

Lys Ile Ser Ser Thr Arg Ile Arg Gln Ala Ile Leu Asp Gly Asn Val 
                165                 170                 175     

Lys Glu Ala Gly Lys Leu Leu Gly Ala Pro Leu Pro Ser Arg Gly Met 
            180                 185                 190         

Val Val His Gly Asn Ala Arg Gly Arg Thr Ile Gly Tyr Pro Thr Ala 
        195                 200                 205             

Asn Leu Val Leu Leu Asp Arg Thr Tyr Met Pro Ala Asp Gly Val Tyr 
    210                 215                 220                 

Val Val Asp Val Glu Ile Gln Arg Gln Lys Tyr Arg Ala Met Ala Ser 
225                 230                 235                 240 

Val Gly Lys Asn Val Thr Phe Asp Gly Glu Glu Ala Arg Phe Glu Val 
                245                 250                 255     

Asn Ile Phe Asp Phe Asn Gln Asp Ile Tyr Gly Glu Thr Val Met Val 
            260                 265                 270         

Tyr Trp Leu Asp Arg Ile Arg Asp Met Thr Lys Phe Asp Ser Val Asp 
        275                 280                 285             

Gln Leu Val Asp Gln Leu Lys Ala Asp Glu Glu Val Thr Arg Asn Trp 
    290                 295                 300                 

Ser 
305 

<210>   2211
<211>   846
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2211
atgattaaaa aaatttaccc catttttacc attttactag gtgctgctat ttatgctttt   60
ggactgactt attttgtagt tccccatcat ctctttgaag gaggggcgac aggcattacc   120
ctcatcacct tttatctttt taaaatccct gtttccctca tgaacctgct gattaatatt   180
ccccttttca tcctagcttg gaagattttt ggagccaaat ccctctattc tagtttacta   240
ggaaccttag ctttgtccgg ctggttagct ttttttgagc atattcccct tcatattgat   300
cttcaaggtg atttactaat cacagccctt atagcgggaa tcctattggg aattggcctt   360
ggaattattt ttaatgctgg aggtacaact ggcggaactg atattctagc tcgtattctc   420
aacaaataca ctcatatatc cataggaaaa ctgctcttta tcttagattt ttgtattctc   480
atgttgattc tcctaatctt caaggatttg agattggttt cctacacgct tttgtttgat   540
tttattgttt ctcgtgttat tgatttgatt ggtgaaggag gatatgccgg caaaggcttt   600
atgattatca caaaacgtcc tgaccaactt gctaaggcga ttaatgatga cctcggaaga   660
ggtgttactt ttatttctgg tcaaggctac tatagtaaag aaaatttgaa aatcatctac   720
tgtattgtcg gaagaaatga aattgtgaaa acgaaggaaa tgattcatcg aatcgatcct   780
caagccttta taactattac agaagcccat gaaatcctag gagaaggctt cacctttgaa   840
aaagaa                                                              846

<210>   2212
<211>   282
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903062 (e-159)

<400>   2212
Met Ile Lys Lys Ile Tyr Pro Ile Phe Thr Ile Leu Leu Gly Ala Ala 
1               5                   10                  15      

Ile Tyr Ala Phe Gly Leu Thr Tyr Phe Val Val Pro His His Leu Phe 
            20                  25                  30          

Glu Gly Gly Ala Thr Gly Ile Thr Leu Ile Thr Phe Tyr Leu Phe Lys 
        35                  40                  45              

Ile Pro Val Ser Leu Met Asn Leu Leu Ile Asn Ile Pro Leu Phe Ile 
    50                  55                  60                  

Leu Ala Trp Lys Ile Phe Gly Ala Lys Ser Leu Tyr Ser Ser Leu Leu 
65                  70                  75                  80  

Gly Thr Leu Ala Leu Ser Gly Trp Leu Ala Phe Phe Glu His Ile Pro 
                85                  90                  95      

Leu His Ile Asp Leu Gln Gly Asp Leu Leu Ile Thr Ala Leu Ile Ala 
            100                 105                 110         

Gly Ile Leu Leu Gly Ile Gly Leu Gly Ile Ile Phe Asn Ala Gly Gly 
        115                 120                 125             

Thr Thr Gly Gly Thr Asp Ile Leu Ala Arg Ile Leu Asn Lys Tyr Thr 
    130                 135                 140                 

His Ile Ser Ile Gly Lys Leu Leu Phe Ile Leu Asp Phe Cys Ile Leu 
145                 150                 155                 160 

Met Leu Ile Leu Leu Ile Phe Lys Asp Leu Arg Leu Val Ser Tyr Thr 
                165                 170                 175     

Leu Leu Phe Asp Phe Ile Val Ser Arg Val Ile Asp Leu Ile Gly Glu 
            180                 185                 190         

Gly Gly Tyr Ala Gly Lys Gly Phe Met Ile Ile Thr Lys Arg Pro Asp 
        195                 200                 205             

Gln Leu Ala Lys Ala Ile Asn Asp Asp Leu Gly Arg Gly Val Thr Phe 
    210                 215                 220                 

Ile Ser Gly Gln Gly Tyr Tyr Ser Lys Glu Asn Leu Lys Ile Ile Tyr 
225                 230                 235                 240 

Cys Ile Val Gly Arg Asn Glu Ile Val Lys Thr Lys Glu Met Ile His 
                245                 250                 255     

Arg Ile Asp Pro Gln Ala Phe Ile Thr Ile Thr Glu Ala His Glu Ile 
            260                 265                 270         

Leu Gly Glu Gly Phe Thr Phe Glu Lys Glu 
        275                 280         

<210>   2213
<211>   837
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2213
atgacaaaaa ttaagattgt aaccgattca tctgttacta ttgaacctga actagtaaag   60
caattagata ttacaattgt tccattatct gtaatgattg ataatgttgt ttattctgat   120
gcggatttga aagaagaagg taaatttctt cagttgatgc aagaaagtaa gaatcttccg   180
aaaacaagtc agccacctgt aggtgtcttt gctgagattt ttgaagacct atgcaaagat   240
ggtggccaga ttcttgctat tcatatgtcc catgctcttt cgggtacggt agaagcagca   300
cgccaaggtg ctagcctatc tactgcagat gtgactgttg ttgatagttc cttcactgac   360
caagccctga aattccaagt tgttgaggct gcgaagttag ctcaagaagg taaagatatg   420
gaggcaattt tatctcatgt agaagaggtt aaaaaccata cagagcttta tattggtgtt   480
tcaactttgg aaaatcttgt caaaggtgga cgaattagcc gtgtaactgg cttgttgagc   540
tctcttctca atatccgtgc tgtcatgcaa atgaaagacc atgaattgca gccaatggtt   600
aaaggtcgtg gaactaaaac atttaaaaaa tggttagatg agttgataac atcgctttct   660
gaacgtgctg tagcagagat tggaatttca tattctggta gtgatgattg ggcaaaagag   720
atgaaagaaa gcttacaagc ttatgttgaa aagccaattt ctgttttgga aacgggttcc   780
attattcaaa ctcacacggg tgagaacgct tgggctattt tgatacgtta ccactcc      837

<210>   2214
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   degV family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903063 (e-153)

<400>   2214
Met Thr Lys Ile Lys Ile Val Thr Asp Ser Ser Val Thr Ile Glu Pro 
1               5                   10                  15      

Glu Leu Val Lys Gln Leu Asp Ile Thr Ile Val Pro Leu Ser Val Met 
            20                  25                  30          

Ile Asp Asn Val Val Tyr Ser Asp Ala Asp Leu Lys Glu Glu Gly Lys 
        35                  40                  45              

Phe Leu Gln Leu Met Gln Glu Ser Lys Asn Leu Pro Lys Thr Ser Gln 
    50                  55                  60                  

Pro Pro Val Gly Val Phe Ala Glu Ile Phe Glu Asp Leu Cys Lys Asp 
65                  70                  75                  80  

Gly Gly Gln Ile Leu Ala Ile His Met Ser His Ala Leu Ser Gly Thr 
                85                  90                  95      

Val Glu Ala Ala Arg Gln Gly Ala Ser Leu Ser Thr Ala Asp Val Thr 
            100                 105                 110         

Val Val Asp Ser Ser Phe Thr Asp Gln Ala Leu Lys Phe Gln Val Val 
        115                 120                 125             

Glu Ala Ala Lys Leu Ala Gln Glu Gly Lys Asp Met Glu Ala Ile Leu 
    130                 135                 140                 

Ser His Val Glu Glu Val Lys Asn His Thr Glu Leu Tyr Ile Gly Val 
145                 150                 155                 160 

Ser Thr Leu Glu Asn Leu Val Lys Gly Gly Arg Ile Ser Arg Val Thr 
                165                 170                 175     

Gly Leu Leu Ser Ser Leu Leu Asn Ile Arg Ala Val Met Gln Met Lys 
            180                 185                 190         

Asp His Glu Leu Gln Pro Met Val Lys Gly Arg Gly Thr Lys Thr Phe 
        195                 200                 205             

Lys Lys Trp Leu Asp Glu Leu Ile Thr Ser Leu Ser Glu Arg Ala Val 
    210                 215                 220                 


Ala Glu Ile Gly Ile Ser Tyr Ser Gly Ser Asp Asp Trp Ala Lys Glu 
225                 230                 235                 240 

Met Lys Glu Ser Leu Gln Ala Tyr Val Glu Lys Pro Ile Ser Val Leu 
                245                 250                 255     

Glu Thr Gly Ser Ile Ile Gln Thr His Thr Gly Glu Asn Ala Trp Ala 
            260                 265                 270         

Ile Leu Ile Arg Tyr His Ser 
        275                 

<210>   2215
<211>   273
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2215
atggcaaaca aacaagattt gatcgctaaa gtagcagaag ctacagaatt gactaagaaa   60
gactcagcag cagcagttga agctgtattt gcagcagtag ctgactatct tgcagctggt   120
gaaaaagttc aattgatcgg ttttggtaac tttgaagttc gtgagcgcgc agaacgtaaa   180
ggtcgcaacc cacaaactgg taaagaaatg acaattgcag cttctaaagt accagcattc   240
aaagctggta aagctcttaa agacgctgtt aaa                                273

<210>   2216
<211>   91
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding protein HU (hup)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903064 (9.E-46)

<400>   2216
Met Ala Asn Lys Gln Asp Leu Ile Ala Lys Val Ala Glu Ala Thr Glu 
1               5                   10                  15      

Leu Thr Lys Lys Asp Ser Ala Ala Ala Val Glu Ala Val Phe Ala Ala 
            20                  25                  30          

Val Ala Asp Tyr Leu Ala Ala Gly Glu Lys Val Gln Leu Ile Gly Phe 
        35                  40                  45              

Gly Asn Phe Glu Val Arg Glu Arg Ala Glu Arg Lys Gly Arg Asn Pro 
    50                  55                  60                  

Gln Thr Gly Lys Glu Met Thr Ile Ala Ala Ser Lys Val Pro Ala Phe 
65                  70                  75                  80  

Lys Ala Gly Lys Ala Leu Lys Asp Ala Val Lys 
                85                  90      

<210>   2217
<211>   1899
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2217
atgattattt tacaagctaa taaaattgaa cgttcttttg caggagaggt tcttttcgat   60
aatatcaacc tgcaggttga tgaacgagat cggattgctc ttgttgggaa aaatggtgca   120
ggtaagtcta ctcttttgaa gattttagtt ggagaagagg agccaactag cggagaaatc   180
aataagaaaa aagatatttc tctgtcttac ctagcccaag atagccgttt tgagtctgaa   240
aataccatct acgatgaaat gcttcatgtc tttaatgatt tgcgtcggac ggagagacaa   300
ctgcgtcaga tggagctgga gatgggtgaa aagtctggtg aggatttgga taaactgatg   360
tcagattatg accgcttatc tgagaatttt cgccaagcag gtggctttac ctatgaagct   420
gatattcgag cgattttgaa tggattcaag tttgacgagt ctatgtggca gatgaaaatt   480
gctgagcttt ctggtggtca aaatactcgt ttggcacttg ccaaaatgct ccttgaaaag   540
cccaatctct tggtcttgga cgagccaact aaccacttgg atattgaaac catcgcctgg   600
ctagagaatt acttggtaaa ctatagcggt gccctcatta tcgtcagcca cgaccgttat   660
ttcttggaca aggttgcgac aattacgcta gatttgacca agcattcctt ggatcgctat   720
gtggggaatt actctcgttt tgtcgaattg aaggagcaaa agctagttac tgaggcaaaa   780
aactatgaaa agcaacagaa ggaaatcgct gctctggaag actttgtcaa tcgcaatcta   840
gttcgtgctt caacgactaa acgtgctcaa tctcgccgta aacaactgga aaaaatggaa   900
cgtttggaca agcctgaagc tggcaagaaa tcagccaaca tgaccttcca gtctgaaaaa   960
acgtcgggca atgttgtttt gactgttgaa aatgcagctg ttggctatga cggggaagtc   1020
ttgtcacaac cgattaacct agatcttcgt aagatgaatg ctgtcgctat cgttggtcca   1080
aatggtatcg gcaagtcaac ctttatcaag tctattgtgg accagattcc ttttatcaag   1140
ggagaaaagc gctttggcgc taatgttgag gttggttact atgaccaaac ccaaagcaag   1200
ctgacaccaa gtaatacggt gctggatgaa ctctggaatg atttcaaact gacaccagaa   1260
gttgaaatcc gcaaccgtct tggagccttc cttttctcag gagatgatgt taaaaaatca   1320
gtcggcatgc tatctggtgg cgaaaaagct cgtttgcttt tagctaaatt gtctatggaa   1380
aacaataact ttttgattct ggatgagccg accaaccact tggatattga tagtaaggaa   1440
gtgctagaaa atgccttgat tgactttgat ggaaccttgc tgtttgtcag tcatgatcgt   1500
tactttatca atcgtgtggc aactcatgtt ttggaattgt ctgagaatgg ttcaactctc   1560
taccttggag attacgacta ctatgttgag aagaaagcaa cagcagaaat gagtcagact   1620
gaggaagctt caactagcaa tcaagcaaag gaagcaagtc cagtcaatga ctatcaggcc   1680
cagaaagaaa gtcaaaaaga agttcgcaaa ctcatgcgac aaatcgaaag tctagaagct   1740
gaaattgaag agctagaaag tcaaagccaa gccatttctg aacaaatgtt ggaaacaaac   1800
gatgccgaca aactcatgga attacaggct gagctggaca aaatcagcca tcgtcaggaa   1860
gaagctatgc ttgagtggga agaattatca gagcaggtg                          1899

<210>   2218
<211>   633
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903065 (0.E+01)

<400>   2218
Met Ile Ile Leu Gln Ala Asn Lys Ile Glu Arg Ser Phe Ala Gly Glu 
1               5                   10                  15      

Val Leu Phe Asp Asn Ile Asn Leu Gln Val Asp Glu Arg Asp Arg Ile 
            20                  25                  30          

Ala Leu Val Gly Lys Asn Gly Ala Gly Lys Ser Thr Leu Leu Lys Ile 
        35                  40                  45              

Leu Val Gly Glu Glu Glu Pro Thr Ser Gly Glu Ile Asn Lys Lys Lys 
    50                  55                  60                  

Asp Ile Ser Leu Ser Tyr Leu Ala Gln Asp Ser Arg Phe Glu Ser Glu 
65                  70                  75                  80  

Asn Thr Ile Tyr Asp Glu Met Leu His Val Phe Asn Asp Leu Arg Arg 
                85                  90                  95      

Thr Glu Arg Gln Leu Arg Gln Met Glu Leu Glu Met Gly Glu Lys Ser 
            100                 105                 110         

Gly Glu Asp Leu Asp Lys Leu Met Ser Asp Tyr Asp Arg Leu Ser Glu 
        115                 120                 125             

Asn Phe Arg Gln Ala Gly Gly Phe Thr Tyr Glu Ala Asp Ile Arg Ala 
    130                 135                 140                 

Ile Leu Asn Gly Phe Lys Phe Asp Glu Ser Met Trp Gln Met Lys Ile 
145                 150                 155                 160 

Ala Glu Leu Ser Gly Gly Gln Asn Thr Arg Leu Ala Leu Ala Lys Met 
                165                 170                 175     

Leu Leu Glu Lys Pro Asn Leu Leu Val Leu Asp Glu Pro Thr Asn His 
            180                 185                 190         

Leu Asp Ile Glu Thr Ile Ala Trp Leu Glu Asn Tyr Leu Val Asn Tyr 
        195                 200                 205             

Ser Gly Ala Leu Ile Ile Val Ser His Asp Arg Tyr Phe Leu Asp Lys 
    210                 215                 220                 

Val Ala Thr Ile Thr Leu Asp Leu Thr Lys His Ser Leu Asp Arg Tyr 
225                 230                 235                 240 

Val Gly Asn Tyr Ser Arg Phe Val Glu Leu Lys Glu Gln Lys Leu Val 
                245                 250                 255     

Thr Glu Ala Lys Asn Tyr Glu Lys Gln Gln Lys Glu Ile Ala Ala Leu 
            260                 265                 270         

Glu Asp Phe Val Asn Arg Asn Leu Val Arg Ala Ser Thr Thr Lys Arg 
        275                 280                 285             

Ala Gln Ser Arg Arg Lys Gln Leu Glu Lys Met Glu Arg Leu Asp Lys 
    290                 295                 300                 

Pro Glu Ala Gly Lys Lys Ser Ala Asn Met Thr Phe Gln Ser Glu Lys 
305                 310                 315                 320 

Thr Ser Gly Asn Val Val Leu Thr Val Glu Asn Ala Ala Val Gly Tyr 
                325                 330                 335     

Asp Gly Glu Val Leu Ser Gln Pro Ile Asn Leu Asp Leu Arg Lys Met 
            340                 345                 350         

Asn Ala Val Ala Ile Val Gly Pro Asn Gly Ile Gly Lys Ser Thr Phe 
        355                 360                 365             

Ile Lys Ser Ile Val Asp Gln Ile Pro Phe Ile Lys Gly Glu Lys Arg 
    370                 375                 380                 

Phe Gly Ala Asn Val Glu Val Gly Tyr Tyr Asp Gln Thr Gln Ser Lys 
385                 390                 395                 400 

Leu Thr Pro Ser Asn Thr Val Leu Asp Glu Leu Trp Asn Asp Phe Lys 
                405                 410                 415     

Leu Thr Pro Glu Val Glu Ile Arg Asn Arg Leu Gly Ala Phe Leu Phe 
            420                 425                 430         

Ser Gly Asp Asp Val Lys Lys Ser Val Gly Met Leu Ser Gly Gly Glu 
        435                 440                 445             

Lys Ala Arg Leu Leu Leu Ala Lys Leu Ser Met Glu Asn Asn Asn Phe 
    450                 455                 460                 

Leu Ile Leu Asp Glu Pro Thr Asn His Leu Asp Ile Asp Ser Lys Glu 
465                 470                 475                 480 

Val Leu Glu Asn Ala Leu Ile Asp Phe Asp Gly Thr Leu Leu Phe Val 
                485                 490                 495     

Ser His Asp Arg Tyr Phe Ile Asn Arg Val Ala Thr His Val Leu Glu 
            500                 505                 510         

Leu Ser Glu Asn Gly Ser Thr Leu Tyr Leu Gly Asp Tyr Asp Tyr Tyr 
        515                 520                 525             

Val Glu Lys Lys Ala Thr Ala Glu Met Ser Gln Thr Glu Glu Ala Ser 
    530                 535                 540                 

Thr Ser Asn Gln Ala Lys Glu Ala Ser Pro Val Asn Asp Tyr Gln Ala 
545                 550                 555                 560 

Gln Lys Glu Ser Gln Lys Glu Val Arg Lys Leu Met Arg Gln Ile Glu 
                565                 570                 575     

Ser Leu Glu Ala Glu Ile Glu Glu Leu Glu Ser Gln Ser Gln Ala Ile 
            580                 585                 590         

Ser Glu Gln Met Leu Glu Thr Asn Asp Ala Asp Lys Leu Met Glu Leu 
        595                 600                 605             

Gln Ala Glu Leu Asp Lys Ile Ser His Arg Gln Glu Glu Ala Met Leu 
    610                 615                 620                 

Glu Trp Glu Glu Leu Ser Glu Gln Val 
625                 630             

<210>   2219
<211>   891
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2219
gtgggaagaa ttatcagagc aggtgtaaag atggaacatc ttggaaaagt atttcgtgaa   60
tttcgaacaa gtggaaatta ttctttaaag gaagcagcag gcgaatcctg ctctacctct   120
cagttatctc gctttgagct tggggagtct gacctggcag tctcccgttt ctttgagatt   180
ttggataaca ttcatgtaac aatcgaaaat ttcatggata aggcaaggaa ttttcataat   240
catgaacatg tgtctatgat ggcacagatt atcccacttt actattcaaa cgatattgca   300
ggttttcaaa agcttcaaag agaacaactt gaaaagtcta agagttcgac gactcccctt   360
tattttgagc tgaactggat tttgctacaa ggtctgattt gtcaaagaga tgcgagttat   420
gatatgaagc aggatgattt gggtaaggta gcagattatc tcttcaaaac agaagaatgg   480
accatgtatg agttgattct tttcggtaac ctctatagtt tctacgatgt agactatgtc   540
actcggattg gtagagaagt tatggagagg gaggaatttt accaagagat tagtcgccat   600
aagagattag tgttgatttt ggccctcaat tgttaccagc attgtttaga gcattcttct   660
ttttataatg ccaactattt tgaggcttat acagagaaga ttattgacaa aggtattaag   720
ctttatgagc gtaatgtttt ccattattta aaaggttttg ccttatatca aaaaggacag   780
tgtaaagaag gctgtaagca gatgcaagag gccatgcata tttttgatgt gttaggtctt   840
ccagagcaag tagcctatta tcaggaacac tacgaaaaat ttgtcaaaag t            891

<210>   2220
<211>   297
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator MutR, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903066 (e-169)

<400>   2220
Met Gly Arg Ile Ile Arg Ala Gly Val Lys Met Glu His Leu Gly Lys 
1               5                   10                  15      

Val Phe Arg Glu Phe Arg Thr Ser Gly Asn Tyr Ser Leu Lys Glu Ala 
            20                  25                  30          

Ala Gly Glu Ser Cys Ser Thr Ser Gln Leu Ser Arg Phe Glu Leu Gly 
        35                  40                  45              

Glu Ser Asp Leu Ala Val Ser Arg Phe Phe Glu Ile Leu Asp Asn Ile 
    50                  55                  60                  

His Val Thr Ile Glu Asn Phe Met Asp Lys Ala Arg Asn Phe His Asn 
65                  70                  75                  80  

His Glu His Val Ser Met Met Ala Gln Ile Ile Pro Leu Tyr Tyr Ser 
                85                  90                  95      

Asn Asp Ile Ala Gly Phe Gln Lys Leu Gln Arg Glu Gln Leu Glu Lys 
            100                 105                 110         

Ser Lys Ser Ser Thr Thr Pro Leu Tyr Phe Glu Leu Asn Trp Ile Leu 
        115                 120                 125             

Leu Gln Gly Leu Ile Cys Gln Arg Asp Ala Ser Tyr Asp Met Lys Gln 
    130                 135                 140                 

Asp Asp Leu Gly Lys Val Ala Asp Tyr Leu Phe Lys Thr Glu Glu Trp 
145                 150                 155                 160 

Thr Met Tyr Glu Leu Ile Leu Phe Gly Asn Leu Tyr Ser Phe Tyr Asp 
                165                 170                 175     

Val Asp Tyr Val Thr Arg Ile Gly Arg Glu Val Met Glu Arg Glu Glu 
            180                 185                 190         

Phe Tyr Gln Glu Ile Ser Arg His Lys Arg Leu Val Leu Ile Leu Ala 
        195                 200                 205             

Leu Asn Cys Tyr Gln His Cys Leu Glu His Ser Ser Phe Tyr Asn Ala 
    210                 215                 220                 

Asn Tyr Phe Glu Ala Tyr Thr Glu Lys Ile Ile Asp Lys Gly Ile Lys 
225                 230                 235                 240 

Leu Tyr Glu Arg Asn Val Phe His Tyr Leu Lys Gly Phe Ala Leu Tyr 
                245                 250                 255     

Gln Lys Gly Gln Cys Lys Glu Gly Cys Lys Gln Met Gln Glu Ala Met 
            260                 265                 270         

His Ile Phe Asp Val Leu Gly Leu Pro Glu Gln Val Ala Tyr Tyr Gln 
        275                 280                 285             

Glu His Tyr Glu Lys Phe Val Lys Ser 
    290                 295         

<210>   2221
<211>   1176

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2221
atgaatcgct atgcagtgca gttgattagc cgtggggcta tcaataaaat gggaaatatg   60
ctctatgatt atggaaatag tgtctggttg gcttctatgg ggactatagg acagacagtt   120
ttaggaatgt atcagatttc tgagctcgtc acatctattc tcgtcaatcc ctttggcgga   180
gttatttcag accgtttttc tcgtcgtaag attttaatga cggcagatct tgtttgtggg   240
attctttgtc tggctatttc tttcataagg aatgatagct ggatgattgg cgctttgatt   300
gttgctaaca ttgtgcaggc tattgctttt gccttttctc gcacagccaa taaagctatc   360
ataactgaag tggtggagaa agatgagatt gtgatctata attctcgctt agagctggtt   420
ttgcaggttg taggtgttag ctctcctgtt ctttccttcc ttgttttaca gtttgcaagt   480
ctccatatga cgctactgct agactcgctg acttttttca ttgcttttgt tctagtggct   540
ttccttccaa aagaggaagc aaaagttcaa gagaaaaagg cttttactgg gagagatatt   600
tttgtagata tcaaggatgg gttacactat atctggcatc agcaagaaat tttcttcctt   660
ttgctggtag cttccagcgt taatttcttt tttgcagctt ttgaatttct acttcccttt   720
tcgaatcagc tttacgggtc agaaggagcc tatgcaagta ttttaactat gggggctatt   780
ggttccatca ttggggctct tctagctagt aaaattaaag ctaatattta taatcttttg   840
attttactgg ctttgacagg tgtcggagtt tttatgatgg gattaccact tccaactttt   900
ctttcctttt ctggaaattt agtttgtgaa ttgtttatga cgatttttaa tattcacttt   960
tttactcaag tacaaaccaa ggttgagagc gaatttcttg gaagagtact gagtacaatt   1020
tttaccttag ctattctatt tatgcctatt gcaaaaggat ttatgacagt cttgccaagt   1080
gtccatcttt attctttctt gattattgga cttggagttg tagccttata tttcttagct   1140
ctcggatatg ttcgaactca ttttgaaaaa ttgata                             1176

<210>   2222
<211>   392
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transporter, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903067 (0.E+01)

<400>   2222
Met Asn Arg Tyr Ala Val Gln Leu Ile Ser Arg Gly Ala Ile Asn Lys 
1               5                   10                  15      


Met Gly Asn Met Leu Tyr Asp Tyr Gly Asn Ser Val Trp Leu Ala Ser 
            20                  25                  30          

Met Gly Thr Ile Gly Gln Thr Val Leu Gly Met Tyr Gln Ile Ser Glu 
        35                  40                  45              

Leu Val Thr Ser Ile Leu Val Asn Pro Phe Gly Gly Val Ile Ser Asp 
    50                  55                  60                  

Arg Phe Ser Arg Arg Lys Ile Leu Met Thr Ala Asp Leu Val Cys Gly 
65                  70                  75                  80  

Ile Leu Cys Leu Ala Ile Ser Phe Ile Arg Asn Asp Ser Trp Met Ile 
                85                  90                  95      

Gly Ala Leu Ile Val Ala Asn Ile Val Gln Ala Ile Ala Phe Ala Phe 
            100                 105                 110         

Ser Arg Thr Ala Asn Lys Ala Ile Ile Thr Glu Val Val Glu Lys Asp 
        115                 120                 125             

Glu Ile Val Ile Tyr Asn Ser Arg Leu Glu Leu Val Leu Gln Val Val 
    130                 135                 140                 

Gly Val Ser Ser Pro Val Leu Ser Phe Leu Val Leu Gln Phe Ala Ser 
145                 150                 155                 160 

Leu His Met Thr Leu Leu Leu Asp Ser Leu Thr Phe Phe Ile Ala Phe 
                165                 170                 175     

Val Leu Val Ala Phe Leu Pro Lys Glu Glu Ala Lys Val Gln Glu Lys 
            180                 185                 190         

Lys Ala Phe Thr Gly Arg Asp Ile Phe Val Asp Ile Lys Asp Gly Leu 
        195                 200                 205             

His Tyr Ile Trp His Gln Gln Glu Ile Phe Phe Leu Leu Leu Val Ala 
    210                 215                 220                 

Ser Ser Val Asn Phe Phe Phe Ala Ala Phe Glu Phe Leu Leu Pro Phe 
225                 230                 235                 240 

Ser Asn Gln Leu Tyr Gly Ser Glu Gly Ala Tyr Ala Ser Ile Leu Thr 
                245                 250                 255     

Met Gly Ala Ile Gly Ser Ile Ile Gly Ala Leu Leu Ala Ser Lys Ile 
            260                 265                 270         

Lys Ala Asn Ile Tyr Asn Leu Leu Ile Leu Leu Ala Leu Thr Gly Val 
        275                 280                 285             

Gly Val Phe Met Met Gly Leu Pro Leu Pro Thr Phe Leu Ser Phe Ser 
    290                 295                 300                 

Gly Asn Leu Val Cys Glu Leu Phe Met Thr Ile Phe Asn Ile His Phe 
305                 310                 315                 320 

Phe Thr Gln Val Gln Thr Lys Val Glu Ser Glu Phe Leu Gly Arg Val 
                325                 330                 335     

Leu Ser Thr Ile Phe Thr Leu Ala Ile Leu Phe Met Pro Ile Ala Lys 
            340                 345                 350         

Gly Phe Met Thr Val Leu Pro Ser Val His Leu Tyr Ser Phe Leu Ile 
        355                 360                 365             

Ile Gly Leu Gly Val Val Ala Leu Tyr Phe Leu Ala Leu Gly Tyr Val 
    370                 375                 380                 

Arg Thr His Phe Glu Lys Leu Ile 
385                 390         

<210>   2223
<211>   1956
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2223
atgaataaaa gaatgaatga gttagtcgct ttgctcaatc gctatgcgac tgagtactat   60
accagcgata atccctcggt ttcagacagt gagtatgacc gcctttaccg tgagttggtc   120
gagttagaaa ctgcttatcc agagcaagtg ctagcagaca gtccgactca tcgtgttggt   180
ggcaaggttt tagatggttt tgaaaaatac agtcatcagt atcctcttta tagtttgcag   240
gatgcttttt catgtgagga gctagatgct tttgatgcgc gtgttcgtaa ggaagtggct   300
catccgacct atatttgtga gctgaaaatc gatggcttat ctatctcgct gacttatgaa   360
aaggggattt tggttgctgg ggtaacacgt ggagatggtt caattggtga aaatatcaca   420
gaaaacctca agcgtgttaa ggacatccct ttgactttgc cagaagaact agatatcaca   480
gttcgtgggg aatgttacat gccacgcgct tcctttgacc aagttaacca agcgcgccaa   540
gaaaatggag agcctgaatt tgctaatcct cgtaatgcgg cagcaggaac tctgcgtcag   600
ttggatacag cagtagttgc caagcgtaat cttgcaacgt ttctctatca agaagccagc   660
ccttcaactc gtgatagcca agaaaagggt ttgaagtacc tagaacaact aggttttgtg   720
gtcaatccta agcgaatctt ggctgaaaac atagatgaaa tctggaattt tatccaagaa   780
gtaggacagg aacgggaaaa tctgccttac gatattgatg gagtggtaat caaggtcaac   840
gacctagcaa gtcaagaaga acttggtttt acagttaagg ctccaaagtg ggcagtagcc   900
tacaagttcc ctgccgaaga aaaagaagct caactcttat cagttgactg gacagttggc   960
cgtaccggtg ttgtaactcc aactgctaat ctaacaccag tacaacttgc cggtacgact   1020
gttagccgtg cgaccctgca caatgtagat tatattgctg aaaaagatat ccgaaaagac   1080
gatacggtca ttgtatataa ggctggtgac atcatccctg ccgttttacg tgtggtagag   1140
tccaaacggg tttctgaaga aaaactagat atccctacaa actgtccaag ttgtaactct   1200
gacttgttgc actttgaaga tgaagtggcc ctacgttgta tcaatccgcg ttgccctgct   1260
caaatcatgg aaggcttgat tcactttgct tctcgtgatg ctatgaatat tacaggcctt   1320
ggtccatcta ttgttgagaa gctttttgct gctaatttag tcaaggatgt ggcggatatt   1380
tatcgtttgc aagaagagga tttcctcctt ttagagggag ttaaggaaaa gtccgctgct   1440
aaactgtatc aggctatcca agcatcaaag gaaaattctg ccgagaagct cttatttggt   1500
ttgggaattc gtcatgtcgg aagcaaggtt agtcagcttt tacttcaata tttccattca   1560
attgaaaatc tgtctcaggc agattcagag gaagtggcta gtattgaaag tctaggtggc   1620
gtgattgcca aaagtcttca gacttatttt gcgacagaag gctctgaaat tctgctcaga   1680
gaattgaaag aaactggggt caatctggac tataaaggac agacggtagt agcggatgcg   1740
gccttgtcag gtttgaccgt ggtattgaca ggaaaattgg aacgactcaa gcgctcagaa   1800
gctaaaagta aactcgaaag tctgggtgcc aaagtgacag gtagtatttc taaaaagacc   1860
gacctcgtcg tggtaggtgc agacgctgga agtaaactgc aaaaagcaca agaacttggt   1920
atccaggtca gagatgaggc atggctagaa agtttg                             1956

<210>   2224
<211>   652
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA ligase, NAD-dependent (ligA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903068 (0.E+01)

<400>   2224
Met Asn Lys Arg Met Asn Glu Leu Val Ala Leu Leu Asn Arg Tyr Ala 
1               5                   10                  15      

Thr Glu Tyr Tyr Thr Ser Asp Asn Pro Ser Val Ser Asp Ser Glu Tyr 
            20                  25                  30          

Asp Arg Leu Tyr Arg Glu Leu Val Glu Leu Glu Thr Ala Tyr Pro Glu 
        35                  40                  45              

Gln Val Leu Ala Asp Ser Pro Thr His Arg Val Gly Gly Lys Val Leu 
    50                  55                  60                  

Asp Gly Phe Glu Lys Tyr Ser His Gln Tyr Pro Leu Tyr Ser Leu Gln 
65                  70                  75                  80  

Asp Ala Phe Ser Cys Glu Glu Leu Asp Ala Phe Asp Ala Arg Val Arg 
                85                  90                  95      

Lys Glu Val Ala His Pro Thr Tyr Ile Cys Glu Leu Lys Ile Asp Gly 
            100                 105                 110         

Leu Ser Ile Ser Leu Thr Tyr Glu Lys Gly Ile Leu Val Ala Gly Val 
        115                 120                 125             

Thr Arg Gly Asp Gly Ser Ile Gly Glu Asn Ile Thr Glu Asn Leu Lys 
    130                 135                 140                 

Arg Val Lys Asp Ile Pro Leu Thr Leu Pro Glu Glu Leu Asp Ile Thr 
145                 150                 155                 160 

Val Arg Gly Glu Cys Tyr Met Pro Arg Ala Ser Phe Asp Gln Val Asn 
                165                 170                 175     

Gln Ala Arg Gln Glu Asn Gly Glu Pro Glu Phe Ala Asn Pro Arg Asn 
            180                 185                 190         

Ala Ala Ala Gly Thr Leu Arg Gln Leu Asp Thr Ala Val Val Ala Lys 
        195                 200                 205             

Arg Asn Leu Ala Thr Phe Leu Tyr Gln Glu Ala Ser Pro Ser Thr Arg 
    210                 215                 220                 

Asp Ser Gln Glu Lys Gly Leu Lys Tyr Leu Glu Gln Leu Gly Phe Val 
225                 230                 235                 240 

Val Asn Pro Lys Arg Ile Leu Ala Glu Asn Ile Asp Glu Ile Trp Asn 
                245                 250                 255     

Phe Ile Gln Glu Val Gly Gln Glu Arg Glu Asn Leu Pro Tyr Asp Ile 
            260                 265                 270         

Asp Gly Val Val Ile Lys Val Asn Asp Leu Ala Ser Gln Glu Glu Leu 
        275                 280                 285             

Gly Phe Thr Val Lys Ala Pro Lys Trp Ala Val Ala Tyr Lys Phe Pro 
    290                 295                 300                 

Ala Glu Glu Lys Glu Ala Gln Leu Leu Ser Val Asp Trp Thr Val Gly 
305                 310                 315                 320 

Arg Thr Gly Val Val Thr Pro Thr Ala Asn Leu Thr Pro Val Gln Leu 
                325                 330                 335     

Ala Gly Thr Thr Val Ser Arg Ala Thr Leu His Asn Val Asp Tyr Ile 
            340                 345                 350         

Ala Glu Lys Asp Ile Arg Lys Asp Asp Thr Val Ile Val Tyr Lys Ala 
        355                 360                 365             

Gly Asp Ile Ile Pro Ala Val Leu Arg Val Val Glu Ser Lys Arg Val 
    370                 375                 380                 

Ser Glu Glu Lys Leu Asp Ile Pro Thr Asn Cys Pro Ser Cys Asn Ser 
385                 390                 395                 400 

Asp Leu Leu His Phe Glu Asp Glu Val Ala Leu Arg Cys Ile Asn Pro 
                405                 410                 415     

Arg Cys Pro Ala Gln Ile Met Glu Gly Leu Ile His Phe Ala Ser Arg 
            420                 425                 430         

Asp Ala Met Asn Ile Thr Gly Leu Gly Pro Ser Ile Val Glu Lys Leu 
        435                 440                 445             

Phe Ala Ala Asn Leu Val Lys Asp Val Ala Asp Ile Tyr Arg Leu Gln 
    450                 455                 460                 

Glu Glu Asp Phe Leu Leu Leu Glu Gly Val Lys Glu Lys Ser Ala Ala 
465                 470                 475                 480 

Lys Leu Tyr Gln Ala Ile Gln Ala Ser Lys Glu Asn Ser Ala Glu Lys 
                485                 490                 495     

Leu Leu Phe Gly Leu Gly Ile Arg His Val Gly Ser Lys Val Ser Gln 
            500                 505                 510         

Leu Leu Leu Gln Tyr Phe His Ser Ile Glu Asn Leu Ser Gln Ala Asp 
        515                 520                 525             

Ser Glu Glu Val Ala Ser Ile Glu Ser Leu Gly Gly Val Ile Ala Lys 
    530                 535                 540                 

Ser Leu Gln Thr Tyr Phe Ala Thr Glu Gly Ser Glu Ile Leu Leu Arg 
545                 550                 555                 560 

Glu Leu Lys Glu Thr Gly Val Asn Leu Asp Tyr Lys Gly Gln Thr Val 
                565                 570                 575     

Val Ala Asp Ala Ala Leu Ser Gly Leu Thr Val Val Leu Thr Gly Lys 
            580                 585                 590         

Leu Glu Arg Leu Lys Arg Ser Glu Ala Lys Ser Lys Leu Glu Ser Leu 
        595                 600                 605             

Gly Ala Lys Val Thr Gly Ser Ile Ser Lys Lys Thr Asp Leu Val Val 
    610                 615                 620                 

Val Gly Ala Asp Ala Gly Ser Lys Leu Gln Lys Ala Gln Glu Leu Gly 
625                 630                 635                 640 

Ile Gln Val Arg Asp Glu Ala Trp Leu Glu Ser Leu 
                645                 650         

<210>   2225
<211>   2277
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2225
atgtataact accctatgcg cattcattac catcgtaaga atggagaata tgacacttgc   60
tcctttgtaa aaagtcagga tcaacgaatt gatttgctaa cctacaaaga agattatttt   120
ggagctttat ttagctttga acacccaagt tcacatgtta tagaaagctt gaattttgtg   180
gttcatacag gtcaaactag taaagaatat tctatccgtt ttaatcacta tcccctatta   240
acagaggtct ggattttgga aggcgatgat aggatttatt actctgaaaa tcctgctatt   300
gccagtcctt tctataaaaa tcaaaatcct tttgcctttg ataaggccat taacagtgct   360
agttttgatc atcattgggg ttaccaagga gaattgggtt gccgtgtaga ggacaatcag   420
gctcattttt ctctctggtc acctacagcg acagaagtgc aagttgtcgt ttatgaatca   480
gctgctaatg atgcacccgt ttggaagact tttgagatga aaagaggcaa tagctactct   540
tataatcata aggacaatac aatcggtgtc tggagtttgg atgttgaaga agatttggta   600
ggtaagactt atcagtatca agtccaattc cctcatcacc aaacactgac acgtgatcct   660
tatacaatcg cgaccagccc tgatggcaaa cgttcagcta ttctgagcca tgtagaaaag   720
caagttgaaa acttcgaggt taagcacggt tcggaggcta cttggcgctt ggaaaatcca   780
tgtaaggcag ttatctgtga aatgcacatt cgtgatttga ctaaatcacc tacatcgggt   840
gtagatgaac atcttcgagg aactttcttg ggtgctgctc aggctggaac agttaaccaa   900
tacggccagt caactgcttt tgattacatc aagaagctgg gctacaatta tgttcaattg   960
caaccaattg cagaccgtca taaagaatac gatgaggatg gaaatgtaac ctacaactgg   1020
ggttatgatc cacaaaacta taacgcgcca gaaactagtt tttcaactaa tccagatgat   1080
ccagctcagg tcattcgtga tttgaaggtg atggttcaag cttatcacga tgcgggtatt   1140
ggagtcatta tggatgtagt ctataaccat accttctcag ttgttgatgc accattccaa   1200
acaacagtcc ctgattacta ttatcgtatg aatccagatg gtaccttcca gaatggaacg   1260
ggtgttggaa atgaaacagc cagtgaacac gaaatgtttc gcaagtatat gattgattct   1320
cttctatact gggtgcagga atataatatt gacggcttcc gttttgactt gatggggatt   1380
catgatgtca agaccatgca gatgattcgt caaagcttgg atgaaatcga ctccaacatt   1440
atcctctatg gagaaggatg ggatatggga acaggtcttg ccccttatga taaggccaag   1500
aaggacaatg cctaccagat gccaaatatt ggtttcttta atgacaatca gcgcgatgct   1560
gtcaaagggg gagaagttta tggtgctatc aagtcaggtt ttgtcagtgg tgctgcgaca   1620
gagccaattc tagctaaagc aatcctagga agtcgtgaat taggaagcta tacacatcca   1680
aatcaggtgc ttaactatgt agaagcccat gacaattaca atcttcacga tttattggca   1740
acccttcatc cagaccaaag ttcagagcaa atcatgcgca aggtcgaaac tgccacagcc   1800
atgaatctgc tcatgcaggg gatggccttt atggaaatcg gtcaagaatt tggtcgtacc   1860
aaactggttg cgactggtga aaatggtgag ttgacccatg atgatagaga gcgtgcgatg   1920
aatagctata atgctcctga cagtgtgaac caagtgaact ggaacttgat taatgagcgt   1980
caagacagta ttgagtttat ccgtcaagtc atccgattga agacaaaaac tggtgccttt   2040
tcttactcta gctatgatga aatttaccat catgtctttg tgcattctgc gattgaacat   2100
agcggctacc ttatctatga agttcacggc aaagaacacc tcttggtggt tgtgaatgct   2160
aaatcagaac cctatcaatt tgaaaatgca ggaaatttag ctatgttggt aaccaacagt   2220
cgctcaaaag aagataatgt tttaaatgat attagtctag ctgtcttgag tgtttta      2277

<210>   2226
<211>   759
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pullulanase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903069 (0.E+01)

<400>   2226
Met Tyr Asn Tyr Pro Met Arg Ile His Tyr His Arg Lys Asn Gly Glu 
1               5                   10                  15      

Tyr Asp Thr Cys Ser Phe Val Lys Ser Gln Asp Gln Arg Ile Asp Leu 
            20                  25                  30          

Leu Thr Tyr Lys Glu Asp Tyr Phe Gly Ala Leu Phe Ser Phe Glu His 
        35                  40                  45              

Pro Ser Ser His Val Ile Glu Ser Leu Asn Phe Val Val His Thr Gly 
    50                  55                  60                  

Gln Thr Ser Lys Glu Tyr Ser Ile Arg Phe Asn His Tyr Pro Leu Leu 
65                  70                  75                  80  

Thr Glu Val Trp Ile Leu Glu Gly Asp Asp Arg Ile Tyr Tyr Ser Glu 
                85                  90                  95      

Asn Pro Ala Ile Ala Ser Pro Phe Tyr Lys Asn Gln Asn Pro Phe Ala 
            100                 105                 110         

Phe Asp Lys Ala Ile Asn Ser Ala Ser Phe Asp His His Trp Gly Tyr 
        115                 120                 125             

Gln Gly Glu Leu Gly Cys Arg Val Glu Asp Asn Gln Ala His Phe Ser 
    130                 135                 140                 

Leu Trp Ser Pro Thr Ala Thr Glu Val Gln Val Val Val Tyr Glu Ser 
145                 150                 155                 160 

Ala Ala Asn Asp Ala Pro Val Trp Lys Thr Phe Glu Met Lys Arg Gly 
                165                 170                 175     

Asn Ser Tyr Ser Tyr Asn His Lys Asp Asn Thr Ile Gly Val Trp Ser 
            180                 185                 190         

Leu Asp Val Glu Glu Asp Leu Val Gly Lys Thr Tyr Gln Tyr Gln Val 
        195                 200                 205             

Gln Phe Pro His His Gln Thr Leu Thr Arg Asp Pro Tyr Thr Ile Ala 
    210                 215                 220                 

Thr Ser Pro Asp Gly Lys Arg Ser Ala Ile Leu Ser His Val Glu Lys 
225                 230                 235                 240 

Gln Val Glu Asn Phe Glu Val Lys His Gly Ser Glu Ala Thr Trp Arg 
                245                 250                 255     

Leu Glu Asn Pro Cys Lys Ala Val Ile Cys Glu Met His Ile Arg Asp 
            260                 265                 270         

Leu Thr Lys Ser Pro Thr Ser Gly Val Asp Glu His Leu Arg Gly Thr 
        275                 280                 285             

Phe Leu Gly Ala Ala Gln Ala Gly Thr Val Asn Gln Tyr Gly Gln Ser 
    290                 295                 300                 

Thr Ala Phe Asp Tyr Ile Lys Lys Leu Gly Tyr Asn Tyr Val Gln Leu 
305                 310                 315                 320 

Gln Pro Ile Ala Asp Arg His Lys Glu Tyr Asp Glu Asp Gly Asn Val 
                325                 330                 335     

Thr Tyr Asn Trp Gly Tyr Asp Pro Gln Asn Tyr Asn Ala Pro Glu Thr 
            340                 345                 350         

Ser Phe Ser Thr Asn Pro Asp Asp Pro Ala Gln Val Ile Arg Asp Leu 
        355                 360                 365             

Lys Val Met Val Gln Ala Tyr His Asp Ala Gly Ile Gly Val Ile Met 
    370                 375                 380                 

Asp Val Val Tyr Asn His Thr Phe Ser Val Val Asp Ala Pro Phe Gln 
385                 390                 395                 400 

Thr Thr Val Pro Asp Tyr Tyr Tyr Arg Met Asn Pro Asp Gly Thr Phe 
                405                 410                 415     

Gln Asn Gly Thr Gly Val Gly Asn Glu Thr Ala Ser Glu His Glu Met 
            420                 425                 430         

Phe Arg Lys Tyr Met Ile Asp Ser Leu Leu Tyr Trp Val Gln Glu Tyr 
        435                 440                 445             

Asn Ile Asp Gly Phe Arg Phe Asp Leu Met Gly Ile His Asp Val Lys 
    450                 455                 460                 

Thr Met Gln Met Ile Arg Gln Ser Leu Asp Glu Ile Asp Ser Asn Ile 
465                 470                 475                 480 

Ile Leu Tyr Gly Glu Gly Trp Asp Met Gly Thr Gly Leu Ala Pro Tyr 
                485                 490                 495     

Asp Lys Ala Lys Lys Asp Asn Ala Tyr Gln Met Pro Asn Ile Gly Phe 
            500                 505                 510         

Phe Asn Asp Asn Gln Arg Asp Ala Val Lys Gly Gly Glu Val Tyr Gly 
        515                 520                 525             

Ala Ile Lys Ser Gly Phe Val Ser Gly Ala Ala Thr Glu Pro Ile Leu 
    530                 535                 540                 

Ala Lys Ala Ile Leu Gly Ser Arg Glu Leu Gly Ser Tyr Thr His Pro 
545                 550                 555                 560 

Asn Gln Val Leu Asn Tyr Val Glu Ala His Asp Asn Tyr Asn Leu His 
                565                 570                 575     

Asp Leu Leu Ala Thr Leu His Pro Asp Gln Ser Ser Glu Gln Ile Met 
            580                 585                 590         

Arg Lys Val Glu Thr Ala Thr Ala Met Asn Leu Leu Met Gln Gly Met 
        595                 600                 605             

Ala Phe Met Glu Ile Gly Gln Glu Phe Gly Arg Thr Lys Leu Val Ala 
    610                 615                 620                 

Thr Gly Glu Asn Gly Glu Leu Thr His Asp Asp Arg Glu Arg Ala Met 
625                 630                 635                 640 

Asn Ser Tyr Asn Ala Pro Asp Ser Val Asn Gln Val Asn Trp Asn Leu 
                645                 650                 655     

Ile Asn Glu Arg Gln Asp Ser Ile Glu Phe Ile Arg Gln Val Ile Arg 
            660                 665                 670         

Leu Lys Thr Lys Thr Gly Ala Phe Ser Tyr Ser Ser Tyr Asp Glu Ile 
        675                 680                 685             

Tyr His His Val Phe Val His Ser Ala Ile Glu His Ser Gly Tyr Leu 
    690                 695                 700                 

Ile Tyr Glu Val His Gly Lys Glu His Leu Leu Val Val Val Asn Ala 
705                 710                 715                 720 

Lys Ser Glu Pro Tyr Gln Phe Glu Asn Ala Gly Asn Leu Ala Met Leu 
                725                 730                 735     

Val Thr Asn Ser Arg Ser Lys Glu Asp Asn Val Leu Asn Asp Ile Ser 
            740                 745                 750         

Leu Ala Val Leu Ser Val Leu 
        755                 

<210>   2227
<211>   1422
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2227
ttgacaagat atcagaattt agtaaatgga aaatggaaat catctgaaca agaaattacg   60
atttattcac caatcaatca agaagaattg ggtacagttc cagccatgac tcagactgaa   120
gctgatgagg ctatgcaagc tgcgcgtgca gccctgccag catggcgagc tttatcagca   180
gttgaacgtg cggcttattt gcataaaaca gcagctattt tagaacgcga taaggaagaa   240
attggtacta tccttgccaa agaagtagca aaagggatta aagcagcaat tggagaagta   300
gtgcgtacag cagacttgat tcgttatgct gctgaggaag gtctccgtat cactggacaa   360
gcaatggaag gtggtggttt tgaggcaaca agtaaaaaca aactggctgt tgtccgtcgt   420
gaaccagttg gtatcgtgct agcgattgct ccctttaatt atccagttaa tttatctgct   480
tctaaaattg cacctgcctt gattgcaggg aatgtggtca tgtttaagcc accaacacaa   540
ggttccattt ctggactctt gttggctaaa gcatttgaag aagcagggat tccggcaggt   600
gttttcaaca ccattacagg tcgtggttca gaaattgggg attatatcat tgagcacaaa   660
gaagtcaact tcatcaactt tacaggttca actcctattg gagaacgtat tggtcgttta   720
gctggtatgc gtcctatcat gttggaactt ggtgggaaag atgcagctct tgtactagaa   780
gatgcagatt tggaacatgc tgccaagcaa attgttgcgg gagcctttag ctactcagga   840
caacgttgca cggccattaa acgtgtcatt gttctcgaaa gtgtagcaga taaattagct   900
actttgcttc aggaagaagt ttctaaatta acagttggtg atccatttga caatgctgat   960
attacacctg ttattgacaa tgcttcagcc gacttcattt ggggcttgat tgaggatgca   1020
caagaaaaag aagctcaggc tcttacacca atcaaacgtg agggcaatct tctctggcca   1080
gtgctttttg accaagttac aaaagatatg aaagtggcat gggaagagcc atttggtcct   1140
gttttaccaa tcattcgtgt ggctagtgta gaggaagcta ttgcctttgc caacgaatct   1200
gaattcggcc ttcaatcatc agtctttaca aatgatttca aaaaagcctt tgaaattgct   1260
gaaaaacttg aagtaggtac agtccacatt aataataaaa cccagcgtgg tccagataat   1320
ttcccattcc ttggtgtcaa aggttctgga gctggagtgc aaggaattaa atatagcatt   1380
gaagcgatga caaatgtcaa atccattgtt tttgatgtga aa                      1422

<210>   2228
<211>   474
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent (gapN)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903072 (0.E+01)

<400>   2228
Met Thr Arg Tyr Gln Asn Leu Val Asn Gly Lys Trp Lys Ser Ser Glu 
1               5                   10                  15      

Gln Glu Ile Thr Ile Tyr Ser Pro Ile Asn Gln Glu Glu Leu Gly Thr 
            20                  25                  30          

Val Pro Ala Met Thr Gln Thr Glu Ala Asp Glu Ala Met Gln Ala Ala 
        35                  40                  45              

Arg Ala Ala Leu Pro Ala Trp Arg Ala Leu Ser Ala Val Glu Arg Ala 
    50                  55                  60                  

Ala Tyr Leu His Lys Thr Ala Ala Ile Leu Glu Arg Asp Lys Glu Glu 
65                  70                  75                  80  

Ile Gly Thr Ile Leu Ala Lys Glu Val Ala Lys Gly Ile Lys Ala Ala 
                85                  90                  95      

Ile Gly Glu Val Val Arg Thr Ala Asp Leu Ile Arg Tyr Ala Ala Glu 
            100                 105                 110         

Glu Gly Leu Arg Ile Thr Gly Gln Ala Met Glu Gly Gly Gly Phe Glu 
        115                 120                 125             

Ala Thr Ser Lys Asn Lys Leu Ala Val Val Arg Arg Glu Pro Val Gly 
    130                 135                 140                 

Ile Val Leu Ala Ile Ala Pro Phe Asn Tyr Pro Val Asn Leu Ser Ala 
145                 150                 155                 160 

Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asn Val Val Met Phe Lys 
                165                 170                 175     

Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Lys Ala Phe 
            180                 185                 190         

Glu Glu Ala Gly Ile Pro Ala Gly Val Phe Asn Thr Ile Thr Gly Arg 
        195                 200                 205             

Gly Ser Glu Ile Gly Asp Tyr Ile Ile Glu His Lys Glu Val Asn Phe 
    210                 215                 220                 

Ile Asn Phe Thr Gly Ser Thr Pro Ile Gly Glu Arg Ile Gly Arg Leu 
225                 230                 235                 240 

Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ala Ala 
                245                 250                 255     

Leu Val Leu Glu Asp Ala Asp Leu Glu His Ala Ala Lys Gln Ile Val 
            260                 265                 270         

Ala Gly Ala Phe Ser Tyr Ser Gly Gln Arg Cys Thr Ala Ile Lys Arg 
        275                 280                 285             

Val Ile Val Leu Glu Ser Val Ala Asp Lys Leu Ala Thr Leu Leu Gln 
    290                 295                 300                 

Glu Glu Val Ser Lys Leu Thr Val Gly Asp Pro Phe Asp Asn Ala Asp 
305                 310                 315                 320 

Ile Thr Pro Val Ile Asp Asn Ala Ser Ala Asp Phe Ile Trp Gly Leu 
                325                 330                 335     

Ile Glu Asp Ala Gln Glu Lys Glu Ala Gln Ala Leu Thr Pro Ile Lys 
            340                 345                 350         

Arg Glu Gly Asn Leu Leu Trp Pro Val Leu Phe Asp Gln Val Thr Lys 
        355                 360                 365             

Asp Met Lys Val Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro Ile 
    370                 375                 380                 

Ile Arg Val Ala Ser Val Glu Glu Ala Ile Ala Phe Ala Asn Glu Ser 
385                 390                 395                 400 

Glu Phe Gly Leu Gln Ser Ser Val Phe Thr Asn Asp Phe Lys Lys Ala 
                405                 410                 415     

Phe Glu Ile Ala Glu Lys Leu Glu Val Gly Thr Val His Ile Asn Asn 
            420                 425                 430         

Lys Thr Gln Arg Gly Pro Asp Asn Phe Pro Phe Leu Gly Val Lys Gly 
        435                 440                 445             

Ser Gly Ala Gly Val Gln Gly Ile Lys Tyr Ser Ile Glu Ala Met Thr 
    450                 455                 460                 

Asn Val Lys Ser Ile Val Phe Asp Val Lys 
465                 470                 

<210>   2229
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2229
atgtttttat tatactacct ttttagagaa gattcaagta aattactata cttctttaat   60
tattttgaaa atctacaaca agttcactta ctcgttcaat tg                      102

<210>   2230
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2230
Met Phe Leu Leu Tyr Tyr Leu Phe Arg Glu Asp Ser Ser Lys Leu Leu 
1               5                   10                  15      

Tyr Phe Phe Asn Tyr Phe Glu Asn Leu Gln Gln Val His Leu Leu Val 
            20                  25                  30          

Gln Leu 
        

<210>   2231
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2231

atggataata gagaagcatt aaaaaccttt atgacgggtg aaaattttta tctccaacat   60
tatctaggag cacataggga agaactaaat ggagagcatg gctatacctt ccgtgtttgg   120
gcacctaatg ctcaggctgt tcacttggtt ggtgatttta ccaactggat tgaaaatcag   180
attccaatgg taagaaatga ttttggggtc tgggaagtct ttaccaatat ggctcaagaa   240
gggcatattt acaaatatca tgtcacacgt caaaatggtc atcaactgat gaagattgac   300
ccttttgctg tcaggtatga ggctcgtcca ggaacagggg caatcgtaac agagcttcct   360
gagaagaaat ggaaggatgg actttggctg gcacgaagaa aacgttgggg ctttgaagag   420
cgtcctgtca atatttatga agttcacgct ggatcatgga aaagaaattc tgatggcagt   480
ccttatagtt ttgcccagct caaggatgaa ctcattcctt atctcgttga aatgaactat   540
actcatattg agtttatgcc cttgatgtcc catcctttgg gcttgagttg ggggtatcag   600
cttatgggtt acttcgcttt agagcatgct tatggccgac cagaggagtt tcaagatttt   660
gtcgaggagt gtcataccca taatattggg gttattgtgg actgggtacc agtcacttta   720
ccatcaacga tgatgcct                                                 738

<210>   2232
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   1,4-alpha-glucan branching enzyme, FRAMESHIFT (glgB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903073 (0.E+01)

<400>   2232
Met Asp Asn Arg Glu Ala Leu Lys Thr Phe Met Thr Gly Glu Asn Phe 
1               5                   10                  15      

Tyr Leu Gln His Tyr Leu Gly Ala His Arg Glu Glu Leu Asn Gly Glu 
            20                  25                  30          

His Gly Tyr Thr Phe Arg Val Trp Ala Pro Asn Ala Gln Ala Val His 
        35                  40                  45              

Leu Val Gly Asp Phe Thr Asn Trp Ile Glu Asn Gln Ile Pro Met Val 
    50                  55                  60                  

Arg Asn Asp Phe Gly Val Trp Glu Val Phe Thr Asn Met Ala Gln Glu 
65                  70                  75                  80  

Gly His Ile Tyr Lys Tyr His Val Thr Arg Gln Asn Gly His Gln Leu 
                85                  90                  95      

Met Lys Ile Asp Pro Phe Ala Val Arg Tyr Glu Ala Arg Pro Gly Thr 
            100                 105                 110         

Gly Ala Ile Val Thr Glu Leu Pro Glu Lys Lys Trp Lys Asp Gly Leu 
        115                 120                 125             

Trp Leu Ala Arg Arg Lys Arg Trp Gly Phe Glu Glu Arg Pro Val Asn 
    130                 135                 140                 

Ile Tyr Glu Val His Ala Gly Ser Trp Lys Arg Asn Ser Asp Gly Ser 
145                 150                 155                 160 

Pro Tyr Ser Phe Ala Gln Leu Lys Asp Glu Leu Ile Pro Tyr Leu Val 
                165                 170                 175     

Glu Met Asn Tyr Thr His Ile Glu Phe Met Pro Leu Met Ser His Pro 
            180                 185                 190         

Leu Gly Leu Ser Trp Gly Tyr Gln Leu Met Gly Tyr Phe Ala Leu Glu 
        195                 200                 205             

His Ala Tyr Gly Arg Pro Glu Glu Phe Gln Asp Phe Val Glu Glu Cys 
    210                 215                 220                 

His Thr His Asn Ile Gly Val Ile Val Asp Trp Val Pro Val Thr Leu 
225                 230                 235                 240 

Pro Ser Thr Met Met Pro 
                245     

<210>   2233
<211>   1035
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2233
ttggatggta ttcgtgtgga tgctgttagc aacatgctct atttggacta tgatgatgct   60
ccatggacac ctaataaaga tggcggaaat ctcaactatg aaggttatta tttccttcag   120
cgcttgaatg aggttattaa gttagaatat ccagatgtga tgatgattgc agaagaaagt   180
tcgtctgcga tcaagattac gggaatgaaa gagattggtg gtctaggatt tgactacaaa   240
tggaacatgg gctggatgaa tgatatcctc cgtttctacg aagaagatcc gatctatcgt   300
aaatatgact ttaacctggt gactttcagc tttatgtatg ttttcaagga gaattatctc   360
ttgccattct cgcacgatga agtggttcat ggcaagaaga gtatgatgca taagatgtgg   420
ggagatcgtt acaatcaatt cgcaggcttg cgcaatctct atacgtacca aatttgtcac   480
cctggtaaga aattgctctt catgggtagc gaatacggtc aattcctaga atggaaatct   540
gaagaacagt tggaatggtc taacctagaa gacccaatga atgctaagat gaagtatttc   600
gcttctcagc taaaccagtt ttacaaagat catcgctgtc tgtgggaaat tgataccagc   660
tatgatggta ttgaaatcat tgatgcggat aatcgagacc agagtgttct ttcctttatt   720
cgtaagggta aaaagggaga aatgttagtc tgtatcttta atatggtacc tgttgagcgg   780
aaagatttta caatcggact acccgttgca ggaatttacg aagaagtatg gaatactgag   840
ttggaagagt ggggaggcgt ttggaaagaa cataatcaaa ctgttcaaac gcaagaagga   900
ctatggaaag attatgagca gaccttaacc tttaccctac cggctatggg agcaagtgta   960
tggaaaatca aacgtcgctt gaaatctact aaaaccgtca caaataaaaa ccaaaaagga   1020
gtagaaaatg aaaaa                                                    1035

<210>   2234
<211>   345
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   1,4-alpha-glucan branching enzyme-related

<400>   2234
Met Asp Gly Ile Arg Val Asp Ala Val Ser Asn Met Leu Tyr Leu Asp 
1               5                   10                  15      

Tyr Asp Asp Ala Pro Trp Thr Pro Asn Lys Asp Gly Gly Asn Leu Asn 
            20                  25                  30          

Tyr Glu Gly Tyr Tyr Phe Leu Gln Arg Leu Asn Glu Val Ile Lys Leu 
        35                  40                  45              

Glu Tyr Pro Asp Val Met Met Ile Ala Glu Glu Ser Ser Ser Ala Ile 
    50                  55                  60                  

Lys Ile Thr Gly Met Lys Glu Ile Gly Gly Leu Gly Phe Asp Tyr Lys 
65                  70                  75                  80  

Trp Asn Met Gly Trp Met Asn Asp Ile Leu Arg Phe Tyr Glu Glu Asp 
                85                  90                  95      

Pro Ile Tyr Arg Lys Tyr Asp Phe Asn Leu Val Thr Phe Ser Phe Met 
            100                 105                 110         

Tyr Val Phe Lys Glu Asn Tyr Leu Leu Pro Phe Ser His Asp Glu Val 
        115                 120                 125             

Val His Gly Lys Lys Ser Met Met His Lys Met Trp Gly Asp Arg Tyr 
    130                 135                 140                 

Asn Gln Phe Ala Gly Leu Arg Asn Leu Tyr Thr Tyr Gln Ile Cys His 
145                 150                 155                 160 

Pro Gly Lys Lys Leu Leu Phe Met Gly Ser Glu Tyr Gly Gln Phe Leu 
                165                 170                 175     

Glu Trp Lys Ser Glu Glu Gln Leu Glu Trp Ser Asn Leu Glu Asp Pro 
            180                 185                 190         

Met Asn Ala Lys Met Lys Tyr Phe Ala Ser Gln Leu Asn Gln Phe Tyr 
        195                 200                 205             

Lys Asp His Arg Cys Leu Trp Glu Ile Asp Thr Ser Tyr Asp Gly Ile 
    210                 215                 220                 

Glu Ile Ile Asp Ala Asp Asn Arg Asp Gln Ser Val Leu Ser Phe Ile 
225                 230                 235                 240 

Arg Lys Gly Lys Lys Gly Glu Met Leu Val Cys Ile Phe Asn Met Val 
                245                 250                 255     

Pro Val Glu Arg Lys Asp Phe Thr Ile Gly Leu Pro Val Ala Gly Ile 
            260                 265                 270         

Tyr Glu Glu Val Trp Asn Thr Glu Leu Glu Glu Trp Gly Gly Val Trp 
        275                 280                 285             

Lys Glu His Asn Gln Thr Val Gln Thr Gln Glu Gly Leu Trp Lys Asp 
    290                 295                 300                 

Tyr Glu Gln Thr Leu Thr Phe Thr Leu Pro Ala Met Gly Ala Ser Val 
305                 310                 315                 320 

Trp Lys Ile Lys Arg Arg Leu Lys Ser Thr Lys Thr Val Thr Asn Lys 
                325                 330                 335     

Asn Gln Lys Gly Val Glu Asn Glu Lys 
            340                 345 

<210>   2235
<211>   1140
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2235
atgaaaaatg aaatgttagc tttgattctt gctggtgggc aaggaactcg tctcggtaaa   60
ctcactcaaa gcatcgcaaa accagctgtg caatttggtg ggcgctaccg tatcattgac   120
tttgccctat caaactgtgc caactcaggg attcacaatg ttggggtcgt tacacagtat   180
caaccacttg ctctcaacaa ccatattggg aatggttcaa gctggggact agacggtatt   240
aattcaggtg tctctattct tcaaccttat tctgcaagtg aaggaaatcg ttggtttgag   300
gggactagtc acgctattta ccaaaatatc gactatatcg acagtgtcaa tcctgagtat   360
gtcttgattt tgtctgggga tcacatctac aaaatggact atgatgatat gctccagtct   420
cataaggata ataatgccag cttgacagta gcagttttag acgtccctct taaagaagca   480
agccgttttg gtatcatgaa cacagatgct aacaatcgta ttgttgaatt tgaagaaaaa   540
ccagctcaac ctaaatctac aaaagcttct atgggaatct acatttttga ttggcaacgc   600
cttcgtaata tgttagtcgc tgctgaaaag agcaaggttg gcatgtcaga ctttggtaaa   660
aatgtcattc caaattacct tgagtcaggt gaaagtgttt atgcttacga atttagtggt   720
tattggaaag atgttggtac tattgagtca ctttgggaag cgaacatgga gtatatttct   780
ccagaaaatg ccttggatag tcgtaaccgt caatggaaga tttactcaag aaacttgatt   840
tcaccaccaa acttcctcgg ggcaaatgct catgtggaag actcattagt tgtagacgga   900
tgtttcgttg atggaactgt taaacattct atcctttcaa caggcgcgca agttcgcgaa   960
ggagcggaag tccttgattc agttatcatg agtggagcta tcattggtca aggagctaag   1020
attaaacgtg ccattattgg tgaaggtgcg attatttctg acggtgtcga aattgatgga   1080
acagatgaag tacaagttgt aggatataat gaagtagtgg gggtagcaac agatgaagat   1140

<210>   2236
<211>   380
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucose-1-phosphate adenylyltransferase (glgC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903074 (0.E+01)

<400>   2236
Met Lys Asn Glu Met Leu Ala Leu Ile Leu Ala Gly Gly Gln Gly Thr 
1               5                   10                  15      

Arg Leu Gly Lys Leu Thr Gln Ser Ile Ala Lys Pro Ala Val Gln Phe 
            20                  25                  30          

Gly Gly Arg Tyr Arg Ile Ile Asp Phe Ala Leu Ser Asn Cys Ala Asn 
        35                  40                  45              

Ser Gly Ile His Asn Val Gly Val Val Thr Gln Tyr Gln Pro Leu Ala 
    50                  55                  60                  

Leu Asn Asn His Ile Gly Asn Gly Ser Ser Trp Gly Leu Asp Gly Ile 
65                  70                  75                  80  

Asn Ser Gly Val Ser Ile Leu Gln Pro Tyr Ser Ala Ser Glu Gly Asn 
                85                  90                  95      

Arg Trp Phe Glu Gly Thr Ser His Ala Ile Tyr Gln Asn Ile Asp Tyr 
            100                 105                 110         

Ile Asp Ser Val Asn Pro Glu Tyr Val Leu Ile Leu Ser Gly Asp His 
        115                 120                 125             

Ile Tyr Lys Met Asp Tyr Asp Asp Met Leu Gln Ser His Lys Asp Asn 
    130                 135                 140                 

Asn Ala Ser Leu Thr Val Ala Val Leu Asp Val Pro Leu Lys Glu Ala 
145                 150                 155                 160 

Ser Arg Phe Gly Ile Met Asn Thr Asp Ala Asn Asn Arg Ile Val Glu 
                165                 170                 175     

Phe Glu Glu Lys Pro Ala Gln Pro Lys Ser Thr Lys Ala Ser Met Gly 
            180                 185                 190         

Ile Tyr Ile Phe Asp Trp Gln Arg Leu Arg Asn Met Leu Val Ala Ala 
        195                 200                 205             

Glu Lys Ser Lys Val Gly Met Ser Asp Phe Gly Lys Asn Val Ile Pro 
    210                 215                 220                 

Asn Tyr Leu Glu Ser Gly Glu Ser Val Tyr Ala Tyr Glu Phe Ser Gly 
225                 230                 235                 240 

Tyr Trp Lys Asp Val Gly Thr Ile Glu Ser Leu Trp Glu Ala Asn Met 
                245                 250                 255     

Glu Tyr Ile Ser Pro Glu Asn Ala Leu Asp Ser Arg Asn Arg Gln Trp 
            260                 265                 270         

Lys Ile Tyr Ser Arg Asn Leu Ile Ser Pro Pro Asn Phe Leu Gly Ala 
        275                 280                 285             

Asn Ala His Val Glu Asp Ser Leu Val Val Asp Gly Cys Phe Val Asp 
    290                 295                 300                 

Gly Thr Val Lys His Ser Ile Leu Ser Thr Gly Ala Gln Val Arg Glu 
305                 310                 315                 320 

Gly Ala Glu Val Leu Asp Ser Val Ile Met Ser Gly Ala Ile Ile Gly 
                325                 330                 335     

Gln Gly Ala Lys Ile Lys Arg Ala Ile Ile Gly Glu Gly Ala Ile Ile 
            340                 345                 350         

Ser Asp Gly Val Glu Ile Asp Gly Thr Asp Glu Val Gln Val Val Gly 
        355                 360                 365             

Tyr Asn Glu Val Val Gly Val Ala Thr Asp Glu Asp 
    370                 375                 380 

<210>   2237
<211>   1137
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2237
atgaagattg ataaatattc tgccatttta ggaaatacag ttggttttca caatatgtcg   60
acattgacgg accaccgtcc agtagcaagt ttgccatttg gtgggaaata tcgtttgatt   120
gacttcccac tttcaagcct tgctaatgca ggtgttcgta gtgtctttgg tattttccag   180
caggataata tcagctcagt atttgaccat attcgttcag gacgcgagtg gggcttatca   240
acccttctta gccattacta tctaggaatt tacaataccc gtgtagaaag tagtacagtt   300
ggaaaagaat actaccaaca gcttcttact tatttgaaac gttctggctc aaaccaaacg   360
gttgccctca actgcgatgt tcttattaac attgatttga accaagtttt ccacctacat   420
agtacaacaa aagagcctat cactgtagtt tataaaaaac tagctaagaa agatatttca   480
gaagtaaatg caatcttgga tgtagatgaa acagaccatg ttctttctca taaactcttt   540
gatagcaagt caacagctga aacgttcaat atgtctacag atatctttgt cgttgataca   600
ccttggttga ttgaacactt ggaagaagaa gctaaaaaag aacatccaga gaaattgcgc   660
tatgttttac gggatttggc tgtaaaagag ggagctttcg cctacgagta cacgggctat   720
ctagccaata ttcactctgt taaatcttat tatcaagcga atatcgatat gcttgaatca   780
caaaaattct attctctttt ctcaccaaac caaaagattt atacaaaggt caaaaacgaa   840
gagccaactt actatgctaa tacatctaag gtaagcactt ctcagtttgc ctctggtagt   900
attattgaag gtcaagtagc taattctgtt ctatcacgta atattcatgt ccataaggat   960
agcttggtta aagatagcct gctcttccct cgtgttgtta ttggagaagg ggctcaggtc   1020
gaatatgcta tcttggacaa aggggttgaa gttgagcatg gtgttgtgat tcgaggaact   1080
gcagaacatc cagttgtggt taagaaaggt gctaaagtaa cagaggatat tcattca      1137

<210>   2238
<211>   379
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycogen biosynthesis protein GlgD (glgD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903075 (0.E+01)

<400>   2238
Met Lys Ile Asp Lys Tyr Ser Ala Ile Leu Gly Asn Thr Val Gly Phe 
1               5                   10                  15      

His Asn Met Ser Thr Leu Thr Asp His Arg Pro Val Ala Ser Leu Pro 
            20                  25                  30          

Phe Gly Gly Lys Tyr Arg Leu Ile Asp Phe Pro Leu Ser Ser Leu Ala 
        35                  40                  45              

Asn Ala Gly Val Arg Ser Val Phe Gly Ile Phe Gln Gln Asp Asn Ile 
    50                  55                  60                  

Ser Ser Val Phe Asp His Ile Arg Ser Gly Arg Glu Trp Gly Leu Ser 
65                  70                  75                  80  

Thr Leu Leu Ser His Tyr Tyr Leu Gly Ile Tyr Asn Thr Arg Val Glu 
                85                  90                  95      

Ser Ser Thr Val Gly Lys Glu Tyr Tyr Gln Gln Leu Leu Thr Tyr Leu 
            100                 105                 110         

Lys Arg Ser Gly Ser Asn Gln Thr Val Ala Leu Asn Cys Asp Val Leu 
        115                 120                 125             

Ile Asn Ile Asp Leu Asn Gln Val Phe His Leu His Ser Thr Thr Lys 
    130                 135                 140                 

Glu Pro Ile Thr Val Val Tyr Lys Lys Leu Ala Lys Lys Asp Ile Ser 
145                 150                 155                 160 

Glu Val Asn Ala Ile Leu Asp Val Asp Glu Thr Asp His Val Leu Ser 
                165                 170                 175     

His Lys Leu Phe Asp Ser Lys Ser Thr Ala Glu Thr Phe Asn Met Ser 
            180                 185                 190         

Thr Asp Ile Phe Val Val Asp Thr Pro Trp Leu Ile Glu His Leu Glu 
        195                 200                 205             

Glu Glu Ala Lys Lys Glu His Pro Glu Lys Leu Arg Tyr Val Leu Arg 
    210                 215                 220                 

Asp Leu Ala Val Lys Glu Gly Ala Phe Ala Tyr Glu Tyr Thr Gly Tyr 
225                 230                 235                 240 

Leu Ala Asn Ile His Ser Val Lys Ser Tyr Tyr Gln Ala Asn Ile Asp 
                245                 250                 255     

Met Leu Glu Ser Gln Lys Phe Tyr Ser Leu Phe Ser Pro Asn Gln Lys 
            260                 265                 270         

Ile Tyr Thr Lys Val Lys Asn Glu Glu Pro Thr Tyr Tyr Ala Asn Thr 
        275                 280                 285             

Ser Lys Val Ser Thr Ser Gln Phe Ala Ser Gly Ser Ile Ile Glu Gly 
    290                 295                 300                 

Gln Val Ala Asn Ser Val Leu Ser Arg Asn Ile His Val His Lys Asp 
305                 310                 315                 320 

Ser Leu Val Lys Asp Ser Leu Leu Phe Pro Arg Val Val Ile Gly Glu 
                325                 330                 335     

Gly Ala Gln Val Glu Tyr Ala Ile Leu Asp Lys Gly Val Glu Val Glu 
            340                 345                 350         

His Gly Val Val Ile Arg Gly Thr Ala Glu His Pro Val Val Val Lys 
        355                 360                 365             

Lys Gly Ala Lys Val Thr Glu Asp Ile His Ser 
    370                 375                 

<210>   2239
<211>   1431
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2239
atgaaaattt tatttgtagc agcagagggt gcaccctttt caaaaacagg tggtttggga   60
gacgtcattg gcgctcttcc aaaatcactg gtaaaagctg ggcacgaagt tgcagtgatt   120
ttaccctact atgatatggt agaggctaaa tttggaaatc agattgaaga tgtgcttcat   180
tttgaggtga gcgttggttg gcgcagacag tattgtggaa ttaagaaaac agtattaaat   240
ggtgtaacct tctactttat tgacaatcaa tattatttct tccgtggtca tgtttacggt   300
gattttgatg acggagaacg ctttgccttt ttccaactgg ctgccattga ggctatggaa   360
aggattgact ttattcctga tcttctccat gttcatgact accatacagc tatgattcct   420
ttcttgttga aggaaaaata ccgttggatt caagcctatg aggacattga aacagtttta   480
accattcata atttagaatt ccaaggacaa ttttcagaag gaatgttggg tgatttgttt   540
ggagttggct ttgaacgtta cgctgatggc acccttcgat ggaacaactg tctgaactgg   600
atgaaggcag gtattctcta tgcgaaccgt gtttcaaccg tttcacctag ctatgctcat   660
gaaattatga ctagtcagtt tggatgtaat ttggatcaga ttcttaaaat ggagtctggt   720
aaagtatctg gtatcgtgaa tgggattgat gctgatcttt ataatcctca gacggatgct   780
cttttagact atcatttcaa tcaggaagat ttgtctggga aagccaaaaa taaggcaaaa   840
ttgcaagaaa gagttggctt gcctgttaga gcagacgttc cactggtggg aattgtttct   900
cgtttgacac gtcaaaaagg ttttgatgtg gtggtcgaaa gtcttcacca tatcttgcaa   960
gaagatgttc agattgttct tttgggaact ggcgatccag cctttgaagg agctttctca   1020
tggtttgctc agatttaccc agacaagcta tcaacaaata tcacttttga tgtcaaactt   1080
gctcaggaaa tctacgctgc ttgtgacctc ttcctcatgc caagtcgttt tgaaccgtgt   1140
ggcttgtctc aaatgatggc tatgcgttat ggaaccttgc cattggtcca tgaagttgga   1200
ggcttgcgag atacagttcg cgctttcaat ccaatcgaag gaagcggtac tggctttagc   1260
tttgacaatc tatctcctta ttggttaaat tggactttcc aaacagcatt ggacttgtat   1320
agaaaccatc cagacatttg gagaaaccta caaaaacaag ctatggagag tgacttctca   1380
tgggatacag cctgcaagtc ataccttgac ttgtaccata gtttagttaa t            1431

<210>   2240
<211>   477
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycogen synthase (glgA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903076 (0.E+01)

<400>   2240
Met Lys Ile Leu Phe Val Ala Ala Glu Gly Ala Pro Phe Ser Lys Thr 
1               5                   10                  15      

Gly Gly Leu Gly Asp Val Ile Gly Ala Leu Pro Lys Ser Leu Val Lys 
            20                  25                  30          

Ala Gly His Glu Val Ala Val Ile Leu Pro Tyr Tyr Asp Met Val Glu 
        35                  40                  45              

Ala Lys Phe Gly Asn Gln Ile Glu Asp Val Leu His Phe Glu Val Ser 
    50                  55                  60                  

Val Gly Trp Arg Arg Gln Tyr Cys Gly Ile Lys Lys Thr Val Leu Asn 
65                  70                  75                  80  

Gly Val Thr Phe Tyr Phe Ile Asp Asn Gln Tyr Tyr Phe Phe Arg Gly 
                85                  90                  95      

His Val Tyr Gly Asp Phe Asp Asp Gly Glu Arg Phe Ala Phe Phe Gln 
            100                 105                 110         

Leu Ala Ala Ile Glu Ala Met Glu Arg Ile Asp Phe Ile Pro Asp Leu 
        115                 120                 125             

Leu His Val His Asp Tyr His Thr Ala Met Ile Pro Phe Leu Leu Lys 
    130                 135                 140                 

Glu Lys Tyr Arg Trp Ile Gln Ala Tyr Glu Asp Ile Glu Thr Val Leu 
145                 150                 155                 160 

Thr Ile His Asn Leu Glu Phe Gln Gly Gln Phe Ser Glu Gly Met Leu 
                165                 170                 175     

Gly Asp Leu Phe Gly Val Gly Phe Glu Arg Tyr Ala Asp Gly Thr Leu 
            180                 185                 190         

Arg Trp Asn Asn Cys Leu Asn Trp Met Lys Ala Gly Ile Leu Tyr Ala 
        195                 200                 205             

Asn Arg Val Ser Thr Val Ser Pro Ser Tyr Ala His Glu Ile Met Thr 
    210                 215                 220                 

Ser Gln Phe Gly Cys Asn Leu Asp Gln Ile Leu Lys Met Glu Ser Gly 
225                 230                 235                 240 

Lys Val Ser Gly Ile Val Asn Gly Ile Asp Ala Asp Leu Tyr Asn Pro 
                245                 250                 255     

Gln Thr Asp Ala Leu Leu Asp Tyr His Phe Asn Gln Glu Asp Leu Ser 
            260                 265                 270         

Gly Lys Ala Lys Asn Lys Ala Lys Leu Gln Glu Arg Val Gly Leu Pro 
        275                 280                 285             

Val Arg Ala Asp Val Pro Leu Val Gly Ile Val Ser Arg Leu Thr Arg 
    290                 295                 300                 

Gln Lys Gly Phe Asp Val Val Val Glu Ser Leu His His Ile Leu Gln 
305                 310                 315                 320 

Glu Asp Val Gln Ile Val Leu Leu Gly Thr Gly Asp Pro Ala Phe Glu 
                325                 330                 335     

Gly Ala Phe Ser Trp Phe Ala Gln Ile Tyr Pro Asp Lys Leu Ser Thr 
            340                 345                 350         

Asn Ile Thr Phe Asp Val Lys Leu Ala Gln Glu Ile Tyr Ala Ala Cys 
        355                 360                 365             

Asp Leu Phe Leu Met Pro Ser Arg Phe Glu Pro Cys Gly Leu Ser Gln 
    370                 375                 380                 

Met Met Ala Met Arg Tyr Gly Thr Leu Pro Leu Val His Glu Val Gly 
385                 390                 395                 400 

Gly Leu Arg Asp Thr Val Arg Ala Phe Asn Pro Ile Glu Gly Ser Gly 
                405                 410                 415     

Thr Gly Phe Ser Phe Asp Asn Leu Ser Pro Tyr Trp Leu Asn Trp Thr 
            420                 425                 430         

Phe Gln Thr Ala Leu Asp Leu Tyr Arg Asn His Pro Asp Ile Trp Arg 
        435                 440                 445             

Asn Leu Gln Lys Gln Ala Met Glu Ser Asp Phe Ser Trp Asp Thr Ala 
    450                 455                 460                 

Cys Lys Ser Tyr Leu Asp Leu Tyr His Ser Leu Val Asn 
465                 470                 475         

<210>   2241
<211>   643
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2241
atgtctcaag taaaaggctt gtgtgttttg gatgtagatg gaaccttaat cctagaagaa   60
gtgattgatc ttttagggag agaggcaggt catgaggcgg aaatttcgca gattacaagt   120
cgagcaatgc gaggagagtt ggtctttgaa agcagtttaa gaaaaagagt gtccttgttg   180
gaaggtcttc ctattttggt ctttgataac gtcttcaact caattcatct atcgctaaat   240
gtcccagagt tcatctctat tctccaaaag aatggcatcc tagttggtct ggtgtctggt   300
ggatttacac caatagttgg agagattagc aaaatccctt ggtattgcct atttcactgc   360
caactagctt gaagtcaaag aaggtctttt aacaggaaaa ttagttggac aaattataag   420
tccccaggtc aaaaaagaga ctctggaaaa atggagaaag aaactaaaac tttctaaaga   480
aagaacggtg gcaatcggtg atggggttaa taatctatta atgttgaagt cggcgaagtt   540
aggaatcgcc ttttgtgcca aagaagtgct caaaaaagaa ataccacatc atgttgacaa   600
gagggatttt ttagaagttc tccctttgat tgactgttta gaa                     643

<210>   2242
<211>   123
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoserine phosphatase SerB, putative, FRAMESHIFT

<400>   2242
Met Ser Gln Val Lys Gly Leu Cys Val Leu Asp Val Asp Gly Thr Leu 
1               5                   10                  15      

Ile Leu Glu Glu Val Ile Asp Leu Leu Gly Arg Glu Ala Gly His Glu 
            20                  25                  30          

Ala Glu Ile Ser Gln Ile Thr Ser Arg Ala Met Arg Gly Glu Leu Val 
        35                  40                  45              

Phe Glu Ser Ser Leu Arg Lys Arg Val Ser Leu Leu Glu Gly Leu Pro 
    50                  55                  60                  

Ile Leu Val Phe Asp Asn Val Phe Asn Ser Ile His Leu Ser Leu Asn 
65                  70                  75                  80  

Val Pro Glu Phe Ile Ser Ile Leu Gln Lys Asn Gly Ile Leu Val Gly 
                85                  90                  95      

Leu Val Ser Gly Gly Phe Thr Pro Ile Val Gly Glu Ile Ser Lys Ile 
            100                 105                 110         

Pro Trp Tyr Cys Leu Phe His Cys Gln Leu Ala 
        115                 120             

<210>   2243
<211>   156
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2243
gtggcaatcg gtgatggggt taataatcta ttaatgttga agtcggcgaa gttaggaatc   60
gccttttgtg ccaaagaagt gctcaaaaaa gaaataccac atcatgttga caagagggat   120
tttttagaag ttctcccttt gattgactgt ttagaa                             156

<210>   2244
<211>   52
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoserine phosphatase-related

<400>   2244
Met Ala Ile Gly Asp Gly Val Asn Asn Leu Leu Met Leu Lys Ser Ala 
1               5                   10                  15      

Lys Leu Gly Ile Ala Phe Cys Ala Lys Glu Val Leu Lys Lys Glu Ile 
            20                  25                  30          

Pro His His Val Asp Lys Arg Asp Phe Leu Glu Val Leu Pro Leu Ile 
        35                  40                  45              

Asp Cys Leu Glu 
    50          

<210>   2245
<211>   1113
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2245
atgaagattg taattgcacc ggattcgttt aaggaaagct tgacagctca acaggtagct   60
gaagcaataa aaagaggctt ccaacaatcg atagcagatg tagaatgtct cctctgccct   120
gttggtgatg ggggagaagg tactgtagat gctatccgac attctcttga cctaaaagaa   180
aaatggatcc aagtgacaga cccttttgga caaaaagaag ccatgcgcta ttttcaaaaa   240
ggggaactgg cactatttga agtagctgac ttggttggtc ttggaaaaat tccgctagag   300
aaacgaaatc cacttcaaat ccaaacttgt ggtattggag agttgattct tcatctcatc   360
tctaaaggga ttaaagatat ttatatcggt gttggtggca cggccagtaa tgatggagga   420
ctggggattg ctgctggttt aggttatcaa ttttatgata gggatggaaa tgtcttgcct   480
gcttccggtc aatccttatt aaacttagct tctgtttcaa cagaaaattg ctataaaatt   540
cctgaaggtg ttcaaattca tattttagca gatgtcgtga gtcccttatg tggtcatcaa   600
ggtgcgactt acacttttgg caatcaaaaa ggtctacatc cgactatgtt tgcagtcgta   660
gatcaggcga tccaagattt ttatgaaaaa ttctcacctg caacattaga aattaaagga   720
gcaggagcag gtggaggcct tgctggtggt ttgtgtgcct ttgctcaggc aagtatcgtg   780
tctggaattg atacctgctt ggacttaatc aactttgata agaaagtttc agatgctgac   840
ttggttgttg ttggagaagg aagacttgat agtcaaagct ttgctgggaa agcgcctata   900
ggtgttgcaa aaagaacccc tgttggagtt cctgttattg ctatttgcgg tagtcttgct   960
gaagatttac ctcccctacc atttgaaaat atccaagctg tcttttctat tttggagaaa   1020
agtgaacctt tagaagatag tttgaaaaat gccagtttct atctggagcg cacggctgcc   1080
aatattgggc acttattaaa tatgtgcaag att                                1113

<210>   2246
<211>   371
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein TIGR00045
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903078 (0.E+01)

<400>   2246
Met Lys Ile Val Ile Ala Pro Asp Ser Phe Lys Glu Ser Leu Thr Ala 
1               5                   10                  15      

Gln Gln Val Ala Glu Ala Ile Lys Arg Gly Phe Gln Gln Ser Ile Ala 
            20                  25                  30          

Asp Val Glu Cys Leu Leu Cys Pro Val Gly Asp Gly Gly Glu Gly Thr 
        35                  40                  45              

Val Asp Ala Ile Arg His Ser Leu Asp Leu Lys Glu Lys Trp Ile Gln 
    50                  55                  60                  

Val Thr Asp Pro Phe Gly Gln Lys Glu Ala Met Arg Tyr Phe Gln Lys 
65                  70                  75                  80  

Gly Glu Leu Ala Leu Phe Glu Val Ala Asp Leu Val Gly Leu Gly Lys 
                85                  90                  95      

Ile Pro Leu Glu Lys Arg Asn Pro Leu Gln Ile Gln Thr Cys Gly Ile 
            100                 105                 110         

Gly Glu Leu Ile Leu His Leu Ile Ser Lys Gly Ile Lys Asp Ile Tyr 
        115                 120                 125             

Ile Gly Val Gly Gly Thr Ala Ser Asn Asp Gly Gly Leu Gly Ile Ala 
    130                 135                 140                 

Ala Gly Leu Gly Tyr Gln Phe Tyr Asp Arg Asp Gly Asn Val Leu Pro 
145                 150                 155                 160 


Ala Ser Gly Gln Ser Leu Leu Asn Leu Ala Ser Val Ser Thr Glu Asn 
                165                 170                 175     

Cys Tyr Lys Ile Pro Glu Gly Val Gln Ile His Ile Leu Ala Asp Val 
            180                 185                 190         

Val Ser Pro Leu Cys Gly His Gln Gly Ala Thr Tyr Thr Phe Gly Asn 
        195                 200                 205             

Gln Lys Gly Leu His Pro Thr Met Phe Ala Val Val Asp Gln Ala Ile 
    210                 215                 220                 

Gln Asp Phe Tyr Glu Lys Phe Ser Pro Ala Thr Leu Glu Ile Lys Gly 
225                 230                 235                 240 

Ala Gly Ala Gly Gly Gly Leu Ala Gly Gly Leu Cys Ala Phe Ala Gln 
                245                 250                 255     

Ala Ser Ile Val Ser Gly Ile Asp Thr Cys Leu Asp Leu Ile Asn Phe 
            260                 265                 270         

Asp Lys Lys Val Ser Asp Ala Asp Leu Val Val Val Gly Glu Gly Arg 
        275                 280                 285             

Leu Asp Ser Gln Ser Phe Ala Gly Lys Ala Pro Ile Gly Val Ala Lys 
    290                 295                 300                 

Arg Thr Pro Val Gly Val Pro Val Ile Ala Ile Cys Gly Ser Leu Ala 
305                 310                 315                 320 

Glu Asp Leu Pro Pro Leu Pro Phe Glu Asn Ile Gln Ala Val Phe Ser 
                325                 330                 335     

Ile Leu Glu Lys Ser Glu Pro Leu Glu Asp Ser Leu Lys Asn Ala Ser 
            340                 345                 350         

Phe Tyr Leu Glu Arg Thr Ala Ala Asn Ile Gly His Leu Leu Asn Met 
        355                 360                 365             

Cys Lys Ile 
    370     

<210>   2247
<211>   444
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2247
atgacagatt tatcaaaaca attacttgaa aaagctcatg gtgggttaaa aataaatccg   60
gatgagcaaa gacgctatct tggtactttt gaggaaagag ttcttggata tgtagatatt   120
gacacagcaa atagccctca gttagaaaaa ggctttttat ttattttaga aaaccttcag   180
gaaaaagcag agccactatt tgtgaagatt tcaccaacta tcgaatttga taagcaagtt   240
ttctacttaa aagaagcaaa agaaactgat agtcaagcca ccatagtatc tgaagagcat   300
attacttctc cttttggcct ggttattcat agcaatgcac cagttcaagt agaagaaaaa   360
gaccttcgac ttgcttttcc aaaactttgg gaagttaaaa aggaagaacc agccaaaaca   420
tccttatgga agaaatggtt tagc                                          444

<210>   2248
<211>   148
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903079 (6.E-83)

<400>   2248
Met Thr Asp Leu Ser Lys Gln Leu Leu Glu Lys Ala His Gly Gly Leu 
1               5                   10                  15      

Lys Ile Asn Pro Asp Glu Gln Arg Arg Tyr Leu Gly Thr Phe Glu Glu 
            20                  25                  30          

Arg Val Leu Gly Tyr Val Asp Ile Asp Thr Ala Asn Ser Pro Gln Leu 
        35                  40                  45              

Glu Lys Gly Phe Leu Phe Ile Leu Glu Asn Leu Gln Glu Lys Ala Glu 
    50                  55                  60                  

Pro Leu Phe Val Lys Ile Ser Pro Thr Ile Glu Phe Asp Lys Gln Val 
65                  70                  75                  80  

Phe Tyr Leu Lys Glu Ala Lys Glu Thr Asp Ser Gln Ala Thr Ile Val 
                85                  90                  95      

Ser Glu Glu His Ile Thr Ser Pro Phe Gly Leu Val Ile His Ser Asn 
            100                 105                 110         

Ala Pro Val Gln Val Glu Glu Lys Asp Leu Arg Leu Ala Phe Pro Lys 
        115                 120                 125             

Leu Trp Glu Val Lys Lys Glu Glu Pro Ala Lys Thr Ser Leu Trp Lys 
    130                 135                 140                 

Lys Trp Phe Ser 
145             

<210>   2249
<211>   1302
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2249
atgtcaatta ttactgatgt ttacgctcgc gaagtcctag actcacgcgg taacccaaca   60
cttgaagtag aagtttacac tgaatcaggt gctttcggac gtggtatggt tccatcagga   120
gcttctactg gtgaacacga agcagttgaa cttcgcgacg gtgacaaatc tcgttacggt   180
ggtcttggta cacaaaaagc tgttgacaac gtaaacaaca tcattgctga agctatcatt   240
ggctacgatg tacgtgatca acaagctatt gaccgtgcta tgatcgcact tgacggtact   300
cctaacaaag gtaaattggg tgcgaatgca atcctcggtg tgtctatcgc tgtagctcgt   360
gctgctgctg actaccttga aatcccactt tacagctatc ttggtggatt caacactaaa   420
gttcttccaa ctccaatgat gaacatcatc aacggtggtt ctcactctga cgctccaatc   480
gctttccaag agttcatgat cttgccagtt ggtgcgccaa catttaaaga agcccttcgt   540
tacggtgctg aaatcttcca cgctcttaag aaaatcctta aatcacgtgg tttggaaact   600
gccgtaggtg acgaaggtgg attcgctcct cgtttcgaag gaactgaaga tggtgttgaa   660
actatccttg ctgcgattga agctgctgga tatgtaccag gtaaagacgt atttatcgga   720
tttgactgtg cttcatcaga attctacgat aaagaacgta aagtttacga ctacactaaa   780
tttgaaggtg aaggtgctgc tgttcgtaca tctgcagaac aaatcgacta ccttgaagaa   840
ttggttaaca aatacccaat catcactatt gaagatggta tggatgaaaa cgactgggat   900
ggttggaaag ctcttactga acgtcttggt aagaaagtac aacttgttgg tgacgacttc   960
ttcgtaacaa acactgacta ccttgcacgt ggtatccaag aaggtgctgc taactcaatc   1020
cttatcaaag ttaaccaaat cggtactctt actgaaactt ttgaagctat cgaaatggct   1080
aaagaagctg gttacactgc tgttgtatca caccgttcag gtgaaactga agattcaaca   1140
atcgctgata ttgcagttgc aactaacgca ggacaaatca agactggttc actttcacgt   1200
acagaccgca tcgctaaata caaccaattg cttcgtatcg aagaccaact tggtgaagta   1260
gctgaatatc gtggattgaa atcattctac aaccttaaaa aa                      1302

<210>   2250
<211>   434
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   enolase (eno)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903080 (0.E+01)


<400>   2250
Met Ser Ile Ile Thr Asp Val Tyr Ala Arg Glu Val Leu Asp Ser Arg 
1               5                   10                  15      

Gly Asn Pro Thr Leu Glu Val Glu Val Tyr Thr Glu Ser Gly Ala Phe 
            20                  25                  30          

Gly Arg Gly Met Val Pro Ser Gly Ala Ser Thr Gly Glu His Glu Ala 
        35                  40                  45              

Val Glu Leu Arg Asp Gly Asp Lys Ser Arg Tyr Gly Gly Leu Gly Thr 
    50                  55                  60                  

Gln Lys Ala Val Asp Asn Val Asn Asn Ile Ile Ala Glu Ala Ile Ile 
65                  70                  75                  80  

Gly Tyr Asp Val Arg Asp Gln Gln Ala Ile Asp Arg Ala Met Ile Ala 
                85                  90                  95      

Leu Asp Gly Thr Pro Asn Lys Gly Lys Leu Gly Ala Asn Ala Ile Leu 
            100                 105                 110         

Gly Val Ser Ile Ala Val Ala Arg Ala Ala Ala Asp Tyr Leu Glu Ile 
        115                 120                 125             

Pro Leu Tyr Ser Tyr Leu Gly Gly Phe Asn Thr Lys Val Leu Pro Thr 
    130                 135                 140                 

Pro Met Met Asn Ile Ile Asn Gly Gly Ser His Ser Asp Ala Pro Ile 
145                 150                 155                 160 

Ala Phe Gln Glu Phe Met Ile Leu Pro Val Gly Ala Pro Thr Phe Lys 
                165                 170                 175     

Glu Ala Leu Arg Tyr Gly Ala Glu Ile Phe His Ala Leu Lys Lys Ile 
            180                 185                 190         

Leu Lys Ser Arg Gly Leu Glu Thr Ala Val Gly Asp Glu Gly Gly Phe 
        195                 200                 205             

Ala Pro Arg Phe Glu Gly Thr Glu Asp Gly Val Glu Thr Ile Leu Ala 
    210                 215                 220                 

Ala Ile Glu Ala Ala Gly Tyr Val Pro Gly Lys Asp Val Phe Ile Gly 
225                 230                 235                 240 

Phe Asp Cys Ala Ser Ser Glu Phe Tyr Asp Lys Glu Arg Lys Val Tyr 
                245                 250                 255     

Asp Tyr Thr Lys Phe Glu Gly Glu Gly Ala Ala Val Arg Thr Ser Ala 
            260                 265                 270         

Glu Gln Ile Asp Tyr Leu Glu Glu Leu Val Asn Lys Tyr Pro Ile Ile 
        275                 280                 285             

Thr Ile Glu Asp Gly Met Asp Glu Asn Asp Trp Asp Gly Trp Lys Ala 
    290                 295                 300                 


Leu Thr Glu Arg Leu Gly Lys Lys Val Gln Leu Val Gly Asp Asp Phe 
305                 310                 315                 320 

Phe Val Thr Asn Thr Asp Tyr Leu Ala Arg Gly Ile Gln Glu Gly Ala 
                325                 330                 335     

Ala Asn Ser Ile Leu Ile Lys Val Asn Gln Ile Gly Thr Leu Thr Glu 
            340                 345                 350         

Thr Phe Glu Ala Ile Glu Met Ala Lys Glu Ala Gly Tyr Thr Ala Val 
        355                 360                 365             

Val Ser His Arg Ser Gly Glu Thr Glu Asp Ser Thr Ile Ala Asp Ile 
    370                 375                 380                 

Ala Val Ala Thr Asn Ala Gly Gln Ile Lys Thr Gly Ser Leu Ser Arg 
385                 390                 395                 400 

Thr Asp Arg Ile Ala Lys Tyr Asn Gln Leu Leu Arg Ile Glu Asp Gln 
                405                 410                 415     

Leu Gly Glu Val Ala Glu Tyr Arg Gly Leu Lys Ser Phe Tyr Asn Leu 
            420                 425                 430         

Lys Lys 
        

<210>   2251
<211>   1161
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2251
atgaatatca aagaaaaaat caaaaagaat ggccaaagag tttattatgc tagtgtttat   60
ctaggcgttg accaactaac gggcaaaaaa gcccgtacaa ctgttacagc aaccactaaa   120
aagggcgtta aagtaaaagc gcgtgatgcg atcaatactt ttgctgctaa tggctataca   180
gttaaagaca agccgacaat tacaacatat aatgagcttg taaaagtttg gtgggatagt   240
tacaagaata cagttaagcc aaatactcgc caatccatgg agggattggt tagagtgcat   300
ttattgcctg tatttggcga ttacaagcta tctaaactta ctacgcctat tcttcaacag   360
caagtaaaca aatgggctga caaggcaaat aaaggcgaaa aaggggcatt tgctaactac   420
tctttgctcc ataacatgaa taagcgtatt ttgaaatatg gcgtagctat ccaggtaata   480
caatacaacc cagctaatga tgtcatcgtt ccacgcaaac agcaaaaaga aaaggctgct   540
gtcaaatact tagacaacaa agaattaaaa cagtttcttg attatttaga tgctctggat   600
caatcaaatt atgagaactt atttgatgtt gttctgtata agactttatt ggccactggt   660
tgccgtatta gtgaggctct ggctcttgaa tggtctgata ttgacctaga aagcggtgtt   720
atcagcatca ataagacact aaaccgctat caggaaataa actcacctaa atcaagcgct   780
ggttatcgtg atataccaat agacaaagcc acattacttt tactgaaaca atacaaaaac   840
cgtcaacaaa ttcagtcttg gaaattaggc cgatctgaaa cagttgtatt ctctgtattt   900
acggagaaat atgcttatgc ttgtaactta cgcaaacgcc taaataagca ttttgatgct   960
gctggagtaa ctaacgtatc atttcatggt ttccgccata cacatactac tatgatgctc   1020
tatgctcagg ttagcccgaa agatgttcag tatagattag gccactctaa tttaatgatc   1080
actgaaaata cttactggca tactaaccaa gagaatgcaa aaaaagccgt ctcaaattat   1140
gaaacagcta tcaacaattt a                                             1161

<210>   2252
<211>   387
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   integrase/recombinase, phage integrase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903090 (2.E-08)

<400>   2252
Met Asn Ile Lys Glu Lys Ile Lys Lys Asn Gly Gln Arg Val Tyr Tyr 
1               5                   10                  15      

Ala Ser Val Tyr Leu Gly Val Asp Gln Leu Thr Gly Lys Lys Ala Arg 
            20                  25                  30          


Thr Thr Val Thr Ala Thr Thr Lys Lys Gly Val Lys Val Lys Ala Arg 
        35                  40                  45              

Asp Ala Ile Asn Thr Phe Ala Ala Asn Gly Tyr Thr Val Lys Asp Lys 
    50                  55                  60                  

Pro Thr Ile Thr Thr Tyr Asn Glu Leu Val Lys Val Trp Trp Asp Ser 
65                  70                  75                  80  

Tyr Lys Asn Thr Val Lys Pro Asn Thr Arg Gln Ser Met Glu Gly Leu 
                85                  90                  95      

Val Arg Val His Leu Leu Pro Val Phe Gly Asp Tyr Lys Leu Ser Lys 
            100                 105                 110         

Leu Thr Thr Pro Ile Leu Gln Gln Gln Val Asn Lys Trp Ala Asp Lys 
        115                 120                 125             

Ala Asn Lys Gly Glu Lys Gly Ala Phe Ala Asn Tyr Ser Leu Leu His 
    130                 135                 140                 

Asn Met Asn Lys Arg Ile Leu Lys Tyr Gly Val Ala Ile Gln Val Ile 
145                 150                 155                 160 

Gln Tyr Asn Pro Ala Asn Asp Val Ile Val Pro Arg Lys Gln Gln Lys 
                165                 170                 175     

Glu Lys Ala Ala Val Lys Tyr Leu Asp Asn Lys Glu Leu Lys Gln Phe 
            180                 185                 190         

Leu Asp Tyr Leu Asp Ala Leu Asp Gln Ser Asn Tyr Glu Asn Leu Phe 
        195                 200                 205             

Asp Val Val Leu Tyr Lys Thr Leu Leu Ala Thr Gly Cys Arg Ile Ser 
    210                 215                 220                 

Glu Ala Leu Ala Leu Glu Trp Ser Asp Ile Asp Leu Glu Ser Gly Val 
225                 230                 235                 240 

Ile Ser Ile Asn Lys Thr Leu Asn Arg Tyr Gln Glu Ile Asn Ser Pro 
                245                 250                 255     

Lys Ser Ser Ala Gly Tyr Arg Asp Ile Pro Ile Asp Lys Ala Thr Leu 
            260                 265                 270         

Leu Leu Leu Lys Gln Tyr Lys Asn Arg Gln Gln Ile Gln Ser Trp Lys 
        275                 280                 285             

Leu Gly Arg Ser Glu Thr Val Val Phe Ser Val Phe Thr Glu Lys Tyr 
    290                 295                 300                 

Ala Tyr Ala Cys Asn Leu Arg Lys Arg Leu Asn Lys His Phe Asp Ala 
305                 310                 315                 320 

Ala Gly Val Thr Asn Val Ser Phe His Gly Phe Arg His Thr His Thr 
                325                 330                 335     

Thr Met Met Leu Tyr Ala Gln Val Ser Pro Lys Asp Val Gln Tyr Arg 
            340                 345                 350         

Leu Gly His Ser Asn Leu Met Ile Thr Glu Asn Thr Tyr Trp His Thr 
        355                 360                 365             

Asn Gln Glu Asn Ala Lys Lys Ala Val Ser Asn Tyr Glu Thr Ala Ile 
    370                 375                 380                 

Asn Asn Leu 
385         

<210>   2253
<211>   846
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2253
atgaaaataa ataataaact cgttggagaa cgtattcaaa atatccgttt aagccatggc   60
gactctatgg aaaaatttgg agaaaaattt aatactagca aaggtacagt taacaactgg   120
gaaaaaggtc gcaatttacc aaataaagaa aacctactaa aaattgcatc tattggaaaa   180
atgagtgttg aagagttact ctacggcgat tacaatactt atctacactt aaagattatg   240
gatttagctc ctgaatgtat aaaaaattat gatgagtata actctttaca cgatgatata   300
acaaataaag cgttacagat cgctcaaaat accatttcta agattgatta tcaaatttca   360
gacgaaacga tcaaaaaatt tattgattta gctatcgaac aatcgagaga tttgcaagga   420
aatttgttga aaaataactt atctaatttt gactattcac tttttggagg tactagaaac   480
cgagaatatt tctattttgg gtatagactt acctataaag aaaaatatct atacactgcc   540
ttactagcta tactgaacga gtcaacaaaa acgatatata ttgatgatat aaatacagca   600
agatttttta acttctttgg caatgatatt cctaattcgt ctttaaaaaa aattgactat   660
atcgcacctt cagaaattgt ttcatttagt acgtacgttc gacaacgttc taaagtaatt   720
cctaaaattt tggaacatat attaaaatca agttttttat tagagaatat agatgtttct   780
ggttacactg taaatatttt agaagatcaa ttaacaaaac atagaacaat caaaattagt   840
aaaaac                                                              846

<210>   2254
<211>   282
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator
<223>   Cellular location: cytoplasm

<400>   2254
Met Lys Ile Asn Asn Lys Leu Val Gly Glu Arg Ile Gln Asn Ile Arg 
1               5                   10                  15      

Leu Ser His Gly Asp Ser Met Glu Lys Phe Gly Glu Lys Phe Asn Thr 
            20                  25                  30          

Ser Lys Gly Thr Val Asn Asn Trp Glu Lys Gly Arg Asn Leu Pro Asn 
        35                  40                  45              

Lys Glu Asn Leu Leu Lys Ile Ala Ser Ile Gly Lys Met Ser Val Glu 
    50                  55                  60                  

Glu Leu Leu Tyr Gly Asp Tyr Asn Thr Tyr Leu His Leu Lys Ile Met 
65                  70                  75                  80  

Asp Leu Ala Pro Glu Cys Ile Lys Asn Tyr Asp Glu Tyr Asn Ser Leu 
                85                  90                  95      

His Asp Asp Ile Thr Asn Lys Ala Leu Gln Ile Ala Gln Asn Thr Ile 
            100                 105                 110         

Ser Lys Ile Asp Tyr Gln Ile Ser Asp Glu Thr Ile Lys Lys Phe Ile 
        115                 120                 125             

Asp Leu Ala Ile Glu Gln Ser Arg Asp Leu Gln Gly Asn Leu Leu Lys 
    130                 135                 140                 

Asn Asn Leu Ser Asn Phe Asp Tyr Ser Leu Phe Gly Gly Thr Arg Asn 
145                 150                 155                 160 

Arg Glu Tyr Phe Tyr Phe Gly Tyr Arg Leu Thr Tyr Lys Glu Lys Tyr 
                165                 170                 175     

Leu Tyr Thr Ala Leu Leu Ala Ile Leu Asn Glu Ser Thr Lys Thr Ile 
            180                 185                 190         

Tyr Ile Asp Asp Ile Asn Thr Ala Arg Phe Phe Asn Phe Phe Gly Asn 
        195                 200                 205             

Asp Ile Pro Asn Ser Ser Leu Lys Lys Ile Asp Tyr Ile Ala Pro Ser 
    210                 215                 220                 

Glu Ile Val Ser Phe Ser Thr Tyr Val Arg Gln Arg Ser Lys Val Ile 
225                 230                 235                 240 

Pro Lys Ile Leu Glu His Ile Leu Lys Ser Ser Phe Leu Leu Glu Asn 
                245                 250                 255     

Ile Asp Val Ser Gly Tyr Thr Val Asn Ile Leu Glu Asp Gln Leu Thr 
            260                 265                 270         

Lys His Arg Thr Ile Lys Ile Ser Lys Asn 
        275                 280         

<210>   2255
<211>   213
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2255
ttgttatttt tccttagccg tgtacgttgg tttggtcgcc tgtacacggc ttttattttc   60
gctttaattc cattttttgc actctttact tttgcatact tctgtttaaa aaatatatct   120
tctattgtaa tatctggaaa taaagggatt aaaagatttt taatcttaag tttttcttta   180
tctgaaaatt gtgtcttccc actttctttg ttg                                213

<210>   2256
<211>   71
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2256
Met Leu Phe Phe Leu Ser Arg Val Arg Trp Phe Gly Arg Leu Tyr Thr 
1               5                   10                  15      

Ala Phe Ile Phe Ala Leu Ile Pro Phe Phe Ala Leu Phe Thr Phe Ala 
            20                  25                  30          

Tyr Phe Cys Leu Lys Asn Ile Ser Ser Ile Val Ile Ser Gly Asn Lys 
        35                  40                  45              

Gly Ile Lys Arg Phe Leu Ile Leu Ser Phe Ser Leu Ser Glu Asn Cys 
    50                  55                  60                  

Val Phe Pro Leu Ser Leu Leu 
65                  70      

<210>   2257
<211>   351
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2257
atgagtaaag aaaacaagat gcgtggatat aggaatatgc taggtttaac acaagagaaa   60
cttggaaaaa aacttggtat atctaagcag agttattaca acaaagaaag tgggaagaca   120
caattttcag ataaagaaaa acttaagatt aaaaatcttt taatcccttt atttccagat   180
attacaatag aagatatatt ttttaaacag aagtatgcaa aagtaaagag tgcaaaaaat   240
ggaattaaag cgaaaataaa agccgtgtac aggcgaccaa accaacgtac acggctaagg   300
aaaaataaca aaactcaagc aaaggcaagg cgcgtggttt tgttaggtat t            351

<210>   2258
<211>   117
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: cytoplasm

<400>   2258
Met Ser Lys Glu Asn Lys Met Arg Gly Tyr Arg Asn Met Leu Gly Leu 
1               5                   10                  15      

Thr Gln Glu Lys Leu Gly Lys Lys Leu Gly Ile Ser Lys Gln Ser Tyr 
            20                  25                  30          

Tyr Asn Lys Glu Ser Gly Lys Thr Gln Phe Ser Asp Lys Glu Lys Leu 
        35                  40                  45              

Lys Ile Lys Asn Leu Leu Ile Pro Leu Phe Pro Asp Ile Thr Ile Glu 
    50                  55                  60                  

Asp Ile Phe Phe Lys Gln Lys Tyr Ala Lys Val Lys Ser Ala Lys Asn 
65                  70                  75                  80  

Gly Ile Lys Ala Lys Ile Lys Ala Val Tyr Arg Arg Pro Asn Gln Arg 
                85                  90                  95      

Thr Arg Leu Arg Lys Asn Asn Lys Thr Gln Ala Lys Ala Arg Arg Val 
            100                 105                 110         

Val Leu Leu Gly Ile 
        115         

<210>   2259
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2259
atggaaattc tgtctaaaga aatacagtta cagggcttac aacttcttaa acagactctt   60
gaaactttag ttgagctaga aaaacaacga tctagtaagt tagatttaat ttctcgtaaa   120
gaattaatgg atctgctagg tataagtgct acaacccttg ataactggga ggatcttggt   180
cttaaacgat atcagactcc gatggatgga gctaagaaag tattctatcg tccgtcagat   240
gtgtatttat ttttagcaat aaaa                                          264

<210>   2260
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2260
Met Glu Ile Leu Ser Lys Glu Ile Gln Leu Gln Gly Leu Gln Leu Leu 
1               5                   10                  15      

Lys Gln Thr Leu Glu Thr Leu Val Glu Leu Glu Lys Gln Arg Ser Ser 
            20                  25                  30          

Lys Leu Asp Leu Ile Ser Arg Lys Glu Leu Met Asp Leu Leu Gly Ile 
        35                  40                  45              

Ser Ala Thr Thr Leu Asp Asn Trp Glu Asp Leu Gly Leu Lys Arg Tyr 
    50                  55                  60                  

Gln Thr Pro Met Asp Gly Ala Lys Lys Val Phe Tyr Arg Pro Ser Asp 
65                  70                  75                  80  

Val Tyr Leu Phe Leu Ala Ile Lys 
                85              


<210>   2261
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2261
atgaaaattg ttactttcaa accaactaaa caaatagacg atgggtttta tctgccaggt   60
attgacattc tatttgtctc agacaaagca gatgccaagg ataaagaaga tgtaatttta   120
tttctttcaa gaaatgggtt aaacaagtct                                    150

<210>   2262
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2262
Met Lys Ile Val Thr Phe Lys Pro Thr Lys Gln Ile Asp Asp Gly Phe 
1               5                   10                  15      

Tyr Leu Pro Gly Ile Asp Ile Leu Phe Val Ser Asp Lys Ala Asp Ala 
            20                  25                  30          

Lys Asp Lys Glu Asp Val Ile Leu Phe Leu Ser Arg Asn Gly Leu Asn 
        35                  40                  45              

Lys Ser 
    50  

<210>   2263
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2263
ttgtatcgct gtatcgatat cctccgtgga atagtagatt tattttctaa tatcattcaa   60

gacttgttta acccatttct tgaaagaaat aaaattacat cttctttatc cttggcatct   120
gctttgtctg agacaaatag aatgtcaata cctggcaga                          159

<210>   2264
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2264
Met Tyr Arg Cys Ile Asp Ile Leu Arg Gly Ile Val Asp Leu Phe Ser 
1               5                   10                  15      

Asn Ile Ile Gln Asp Leu Phe Asn Pro Phe Leu Glu Arg Asn Lys Ile 
            20                  25                  30          

Thr Ser Ser Leu Ser Leu Ala Ser Ala Leu Ser Glu Thr Asn Arg Met 
        35                  40                  45              

Ser Ile Pro Gly Arg 
    50              

<210>   2265
<211>   615
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2265
atggaactag tttacatgga cggtaagaaa gagccgtaca ccacaagcga gatcatcgct   60
gaatgtgctg aagtacaaca ccacactatc acgcgcttaa taagagaaaa taaggctgac   120
tttgaagagt tgggaatact tggatttaaa atccataaat tagatactag aggacaacct   180
aaaaaatcct atattctgaa cgagcaacag gctacttttc tgatcactta tttaaagaat   240
accgaaacag tacggcaatt caaactaaac ctagtcaaag cattctttga aatgcgtgag   300
gaactttctg aaattcgtct gcagagggcg ctagaaaaac cgaaaagaaa aaccttgcat   360
gacagtatag aaacatggcc taatgcacca aagcacgcgc atagcaccat gaacaacttg   420
ctactaaagg cagtaacaga catgaacgct aagcagttaa gagaagagcg tgggggctat   480
aacggtatcg atagcttgac tagtgaggag ttggagcagt accaggcatt tgaggatatg   540
gcaatagcta tgattgaatt gaaaatgagt tatcaggaaa ttaagacaat gatgtttaga   600
agtaaaaaaa taagc                                                    615

<210>   2266
<211>   205
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2266
Met Glu Leu Val Tyr Met Asp Gly Lys Lys Glu Pro Tyr Thr Thr Ser 
1               5                   10                  15      

Glu Ile Ile Ala Glu Cys Ala Glu Val Gln His His Thr Ile Thr Arg 
            20                  25                  30          

Leu Ile Arg Glu Asn Lys Ala Asp Phe Glu Glu Leu Gly Ile Leu Gly 
        35                  40                  45              

Phe Lys Ile His Lys Leu Asp Thr Arg Gly Gln Pro Lys Lys Ser Tyr 
    50                  55                  60                  

Ile Leu Asn Glu Gln Gln Ala Thr Phe Leu Ile Thr Tyr Leu Lys Asn 
65                  70                  75                  80  

Thr Glu Thr Val Arg Gln Phe Lys Leu Asn Leu Val Lys Ala Phe Phe 
                85                  90                  95      

Glu Met Arg Glu Glu Leu Ser Glu Ile Arg Leu Gln Arg Ala Leu Glu 
            100                 105                 110         

Lys Pro Lys Arg Lys Thr Leu His Asp Ser Ile Glu Thr Trp Pro Asn 
        115                 120                 125             

Ala Pro Lys His Ala His Ser Thr Met Asn Asn Leu Leu Leu Lys Ala 
    130                 135                 140                 

Val Thr Asp Met Asn Ala Lys Gln Leu Arg Glu Glu Arg Gly Gly Tyr 
145                 150                 155                 160 

Asn Gly Ile Asp Ser Leu Thr Ser Glu Glu Leu Glu Gln Tyr Gln Ala 
                165                 170                 175     

Phe Glu Asp Met Ala Ile Ala Met Ile Glu Leu Lys Met Ser Tyr Gln 
            180                 185                 190         

Glu Ile Lys Thr Met Met Phe Arg Ser Lys Lys Ile Ser 
        195                 200                 205 

<210>   2267
<211>   450
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2267
atgacagaaa caacatatga gaatttaact agacgtatag acagaattag cgcagaaatg   60
cgagaaatta gcgaagaaaa tggcctaaga atcctttctt tattggaaag tcagacaaaa   120
tccatcaaag atgagttgtc ccgtttactt tggattgaac ttcctgaatt gaatgaaagc   180
cataaaatcg aagcggtctc taaaagcact acgggaatgt ttttcgcccc tggtattttt   240
gaaatggacg ctatgcgaaa agcattcttt aaacgccaag ctaagcactt ttttgagaac   300
gaagcagagc aacaggcgta tatagagcat gctgaaaagg agtatttaga ggctactgta   360
accttaaaag atattctttt taactctaaa aatggaactc agaaagcaaa taaaagttgt   420
cttatagaga agtttgagga ggcaatgcaa                                    450

<210>   2268
<211>   150
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2268
Met Thr Glu Thr Thr Tyr Glu Asn Leu Thr Arg Arg Ile Asp Arg Ile 
1               5                   10                  15      

Ser Ala Glu Met Arg Glu Ile Ser Glu Glu Asn Gly Leu Arg Ile Leu 
            20                  25                  30          

Ser Leu Leu Glu Ser Gln Thr Lys Ser Ile Lys Asp Glu Leu Ser Arg 
        35                  40                  45              

Leu Leu Trp Ile Glu Leu Pro Glu Leu Asn Glu Ser His Lys Ile Glu 
    50                  55                  60                  

Ala Val Ser Lys Ser Thr Thr Gly Met Phe Phe Ala Pro Gly Ile Phe 
65                  70                  75                  80  

Glu Met Asp Ala Met Arg Lys Ala Phe Phe Lys Arg Gln Ala Lys His 
                85                  90                  95      

Phe Phe Glu Asn Glu Ala Glu Gln Gln Ala Tyr Ile Glu His Ala Glu 
            100                 105                 110         

Lys Glu Tyr Leu Glu Ala Thr Val Thr Leu Lys Asp Ile Leu Phe Asn 
        115                 120                 125             

Ser Lys Asn Gly Thr Gln Lys Ala Asn Lys Ser Cys Leu Ile Glu Lys 
    130                 135                 140                 

Phe Glu Glu Ala Met Gln 
145                 150 

<210>   2269
<211>   444
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2269
atgacactag atttagacaa catgacacaa gcagaatttg atgaggtaat ggctgaaatc   60
cagctacaaa gtccaaacat ttttcaactg atttctgatt ttgtaaataa aaaagtaacc   120
agtgtggaaa tagacgactt gttgaatatg aagcgagctg agacaggtaa agcattgtca   180
ccgttacaga ttcaagaatt gcagtatatg ctagaagatt ttagcccaga gcttatccat   240
gaggcgttaa aagaggctgt cagtcagggt aaagcaaact ttgcatacat caaggtaatc   300
cttaaccgtt ggaaacagga caatttattg acggtggaac ttgttagaaa tagcagggca   360
gcgcgtgagg ctaaaaaaca gcaaaccaat caactagagc ctaccagcta tgaagattgg   420
ataccaacac aagaaaaacc attt                                          444

<210>   2270
<211>   148
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903476 (4.E-14)

<400>   2270
Met Thr Leu Asp Leu Asp Asn Met Thr Gln Ala Glu Phe Asp Glu Val 
1               5                   10                  15      

Met Ala Glu Ile Gln Leu Gln Ser Pro Asn Ile Phe Gln Leu Ile Ser 
            20                  25                  30          

Asp Phe Val Asn Lys Lys Val Thr Ser Val Glu Ile Asp Asp Leu Leu 
        35                  40                  45              

Asn Met Lys Arg Ala Glu Thr Gly Lys Ala Leu Ser Pro Leu Gln Ile 
    50                  55                  60                  

Gln Glu Leu Gln Tyr Met Leu Glu Asp Phe Ser Pro Glu Leu Ile His 
65                  70                  75                  80  

Glu Ala Leu Lys Glu Ala Val Ser Gln Gly Lys Ala Asn Phe Ala Tyr 
                85                  90                  95      

Ile Lys Val Ile Leu Asn Arg Trp Lys Gln Asp Asn Leu Leu Thr Val 
            100                 105                 110         

Glu Leu Val Arg Asn Ser Arg Ala Ala Arg Glu Ala Lys Lys Gln Gln 
        115                 120                 125             

Thr Asn Gln Leu Glu Pro Thr Ser Tyr Glu Asp Trp Ile Pro Thr Gln 
    130                 135                 140                 

Glu Lys Pro Phe 
145             

<210>   2271
<211>   924
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2271
ttggatacca acacaagaaa aaccatttta ggaggtcaga aaatgaaatc attacaatct   60
agtttaggaa atattgagac atttaaacta gacgaattgt gtcctaagca tgaaatacag   120
ctaacacaaa tcaaaggaga aagacatgta gtagtggggt ggaatgagaa cggagaggca   180
ataaaagaag ttcgctgtat cccaccctat tgtgaacaat gccaagaaga acagaaaaag   240
caagatgaag aagatgcgat tgctgataat ttgaatgcta aactatatat gcaaacttat   300
aatgtgttga tgagcaataa gagctatgta gcagatgagt ttaaaactaa aacttttgat   360
gattttaatg ctgtaacatc agaagaaaag cgatttttag aatttgcaaa aggtcaggta   420
caaaaatatc ttgatggcat gaggggaaat acgcttatca caggaggtac agggattgga   480
aaaacacttt tatcagttgc tattgccaaa ggtataaatg aggggtataa gacaaaagga   540
gaacctaaga gtgtgctttt tgtaagccta accgaaatga tcaaacaaat taaagagggg   600
tggaattatg gtaaaggtgc aacacttaca gagtttgaag ctactgaact catgaagtct   660
gttgattact taattattga tgatttagga gcaaaaaatg ctgttattaa gcctaagagt   720
gactgggagc aggatttact ctttgacgtg ctaaacaatc gtgaaaatac catttttaat   780
accaacctag atagtgatga gcttaagata gtttacaatg agcggaatta tagccgtatt   840
ctaaaaggac ttgagggtaa cacttttaag gcgtttggca tcaaatataa gcggtactca   900
ctcaatcagt taaagagtaa tatg                                          924

<210>   2272
<211>   308
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP-binding protein, putative
<223>   Cellular location: cytoplasm

<400>   2272
Met Asp Thr Asn Thr Arg Lys Thr Ile Leu Gly Gly Gln Lys Met Lys 
1               5                   10                  15      

Ser Leu Gln Ser Ser Leu Gly Asn Ile Glu Thr Phe Lys Leu Asp Glu 
            20                  25                  30          

Leu Cys Pro Lys His Glu Ile Gln Leu Thr Gln Ile Lys Gly Glu Arg 
        35                  40                  45              

His Val Val Val Gly Trp Asn Glu Asn Gly Glu Ala Ile Lys Glu Val 
    50                  55                  60                  

Arg Cys Ile Pro Pro Tyr Cys Glu Gln Cys Gln Glu Glu Gln Lys Lys 
65                  70                  75                  80  

Gln Asp Glu Glu Asp Ala Ile Ala Asp Asn Leu Asn Ala Lys Leu Tyr 
                85                  90                  95      

Met Gln Thr Tyr Asn Val Leu Met Ser Asn Lys Ser Tyr Val Ala Asp 
            100                 105                 110         

Glu Phe Lys Thr Lys Thr Phe Asp Asp Phe Asn Ala Val Thr Ser Glu 
        115                 120                 125             

Glu Lys Arg Phe Leu Glu Phe Ala Lys Gly Gln Val Gln Lys Tyr Leu 
    130                 135                 140                 

Asp Gly Met Arg Gly Asn Thr Leu Ile Thr Gly Gly Thr Gly Ile Gly 
145                 150                 155                 160 

Lys Thr Leu Leu Ser Val Ala Ile Ala Lys Gly Ile Asn Glu Gly Tyr 
                165                 170                 175     

Lys Thr Lys Gly Glu Pro Lys Ser Val Leu Phe Val Ser Leu Thr Glu 
            180                 185                 190         

Met Ile Lys Gln Ile Lys Glu Gly Trp Asn Tyr Gly Lys Gly Ala Thr 
        195                 200                 205             

Leu Thr Glu Phe Glu Ala Thr Glu Leu Met Lys Ser Val Asp Tyr Leu 
    210                 215                 220                 

Ile Ile Asp Asp Leu Gly Ala Lys Asn Ala Val Ile Lys Pro Lys Ser 
225                 230                 235                 240 

Asp Trp Glu Gln Asp Leu Leu Phe Asp Val Leu Asn Asn Arg Glu Asn 
                245                 250                 255     

Thr Ile Phe Asn Thr Asn Leu Asp Ser Asp Glu Leu Lys Ile Val Tyr 
            260                 265                 270         

Asn Glu Arg Asn Tyr Ser Arg Ile Leu Lys Gly Leu Glu Gly Asn Thr 
        275                 280                 285             

Phe Lys Ala Phe Gly Ile Lys Tyr Lys Arg Tyr Ser Leu Asn Gln Leu 
    290                 295                 300                 

Lys Ser Asn Met 
305             

<210>   2273
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2273
ttggttagtt tgccacactt ggtttatatg gtcgtggaaa gcatggctat tacttctcaa   60
agggcgattt ctcaccccat gaaaagtgtc tatttttgtt taggtttg                108

<210>   2274
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2274
Met Val Ser Leu Pro His Leu Val Tyr Met Val Val Glu Ser Met Ala 
1               5                   10                  15      

Ile Thr Ser Gln Arg Ala Ile Ser His Pro Met Lys Ser Val Tyr Phe 
            20                  25                  30          

Cys Leu Gly Leu 
        35      

<210>   2275
<211>   648
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2275
atgactgaaa acaaggatga taaattatta aaaatgatgg agaaaggctt tgttttatac   60
tcaaaaaatg gtataattaa gtatattgaa attccagagc atgggagtat taagctaaaa   120
gctcaagatg ggcaattagt ttataaggaa gtgattatcg ggaaagtgta tgcagagcaa   180
gaacttttaa aatataaaaa agagggcgaa aactattccc aaaatactgc tcagctattg   240
tatcagcaac tagaaaaaga gaaaaatgct gaactagcaa accatgaatc aaaagaagag   300
cctattacag cagatgatgc agctgaacta agtttattat ctagtatcaa attaacagtg   360
gcagaaatga gagaatacct agaaaaatat aaaaataaac ctctagctct tagaaaatta   420
gaagatatta tggataatga tactaccctt gcttatatcg aaattgacat ggagcaattc   480
agccaacagc aacgccttga aaagctagta catttccttg atagaaaaat tgattatttc   540
cacggtggtt tacttattaa cggagataag attgatttag tacagcatga aatgattgtt   600
gagggcaatt cagaggcaat ggatgcagaa ttgcagaatt atctagca                648

<210>   2276
<211>   216
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2276
Met Thr Glu Asn Lys Asp Asp Lys Leu Leu Lys Met Met Glu Lys Gly 
1               5                   10                  15      

Phe Val Leu Tyr Ser Lys Asn Gly Ile Ile Lys Tyr Ile Glu Ile Pro 
            20                  25                  30          

Glu His Gly Ser Ile Lys Leu Lys Ala Gln Asp Gly Gln Leu Val Tyr 
        35                  40                  45              

Lys Glu Val Ile Ile Gly Lys Val Tyr Ala Glu Gln Glu Leu Leu Lys 
    50                  55                  60                  

Tyr Lys Lys Glu Gly Glu Asn Tyr Ser Gln Asn Thr Ala Gln Leu Leu 
65                  70                  75                  80  

Tyr Gln Gln Leu Glu Lys Glu Lys Asn Ala Glu Leu Ala Asn His Glu 
                85                  90                  95      

Ser Lys Glu Glu Pro Ile Thr Ala Asp Asp Ala Ala Glu Leu Ser Leu 
            100                 105                 110         

Leu Ser Ser Ile Lys Leu Thr Val Ala Glu Met Arg Glu Tyr Leu Glu 
        115                 120                 125             

Lys Tyr Lys Asn Lys Pro Leu Ala Leu Arg Lys Leu Glu Asp Ile Met 
    130                 135                 140                 

Asp Asn Asp Thr Thr Leu Ala Tyr Ile Glu Ile Asp Met Glu Gln Phe 
145                 150                 155                 160 

Ser Gln Gln Gln Arg Leu Glu Lys Leu Val His Phe Leu Asp Arg Lys 
                165                 170                 175     

Ile Asp Tyr Phe His Gly Gly Leu Leu Ile Asn Gly Asp Lys Ile Asp 
            180                 185                 190         

Leu Val Gln His Glu Met Ile Val Glu Gly Asn Ser Glu Ala Met Asp 
        195                 200                 205             

Ala Glu Leu Gln Asn Tyr Leu Ala 
    210                 215     

<210>   2277
<211>   426
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2277
atggcaggaa atgaaaatga taaccttacg tccaagcaaa ttaaattcat agatgccatg   60
cttaccgagc caacgataga caaagcatgt caaaaagcag gggtatcacg cgcaacaggt   120
cataagtatc taaaagttgc agcggttaaa aagacattga ggataaagca agatgagatg   180
atggataaaa caactcaaat gctttattta gcatcatcta acgctgtttc tgtactcaat   240
gatattatga tggacagtaa ggtcaacccg tttataagaa ctcaagcagc aaaggctata   300
cttgaacaat cttataagac ccatgaaatt tttggagtag taaggcagat tgaagaattg   360
aggttggaaa ttgaggaagt atctaaagga aatcaaagag ttacaagaac tcaaggagtt   420
attaag                                                              426

<210>   2278
<211>   142
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2278

Met Ala Gly Asn Glu Asn Asp Asn Leu Thr Ser Lys Gln Ile Lys Phe 
1               5                   10                  15      

Ile Asp Ala Met Leu Thr Glu Pro Thr Ile Asp Lys Ala Cys Gln Lys 
            20                  25                  30          

Ala Gly Val Ser Arg Ala Thr Gly His Lys Tyr Leu Lys Val Ala Ala 
        35                  40                  45              

Val Lys Lys Thr Leu Arg Ile Lys Gln Asp Glu Met Met Asp Lys Thr 
    50                  55                  60                  

Thr Gln Met Leu Tyr Leu Ala Ser Ser Asn Ala Val Ser Val Leu Asn 
65                  70                  75                  80  

Asp Ile Met Met Asp Ser Lys Val Asn Pro Phe Ile Arg Thr Gln Ala 
                85                  90                  95      

Ala Lys Ala Ile Leu Glu Gln Ser Tyr Lys Thr His Glu Ile Phe Gly 
            100                 105                 110         

Val Val Arg Gln Ile Glu Glu Leu Arg Leu Glu Ile Glu Glu Val Ser 
        115                 120                 125             

Lys Gly Asn Gln Arg Val Thr Arg Thr Gln Gly Val Ile Lys 
    130                 135                 140         

<210>   2279
<211>   309
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2279

atgccagagt ttattattgt tgaaggaaac aatgacttag gggaattttt ccaaatagat   60
ggcgagctat ttagtgataa tgaactttta gaaaacctta aaaaatggcg tgagtgggaa   120
gtgccagtta ttattgatga ttggtgcaat cgtatcctaa acgaggatga aacggaaata   180
ctatactttc ctactcatga ggataagatg aactatatta gggtggaaaa agatttagaa   240
cctttgtatc atacatcgaa caagatctat gcaactattt ctaaaagtga gtggttagaa   300
ttgttaaat                                                           309

<210>   2280
<211>   103
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2280
Met Pro Glu Phe Ile Ile Val Glu Gly Asn Asn Asp Leu Gly Glu Phe 
1               5                   10                  15      

Phe Gln Ile Asp Gly Glu Leu Phe Ser Asp Asn Glu Leu Leu Glu Asn 

            20                  25                  30          

Leu Lys Lys Trp Arg Glu Trp Glu Val Pro Val Ile Ile Asp Asp Trp 
        35                  40                  45              

Cys Asn Arg Ile Leu Asn Glu Asp Glu Thr Glu Ile Leu Tyr Phe Pro 
    50                  55                  60                  

Thr His Glu Asp Lys Met Asn Tyr Ile Arg Val Glu Lys Asp Leu Glu 
65                  70                  75                  80  

Pro Leu Tyr His Thr Ser Asn Lys Ile Tyr Ala Thr Ile Ser Lys Ser 
                85                  90                  95      

Glu Trp Leu Glu Leu Leu Asn 
            100             

<210>   2281
<211>   408
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2281
atgacaaaga agaaaattga gcgtatttct gtaatacacc gagaaaagat tttatggctc   60
aagtggtatt tcatgcgaga taaagaacaa cctaagtata gtgtccttga gcgtaaaatg   120
tttgatgctg ctaaaaatca agatatgcta gcttatcaaa aatacgcaac tatcaagcag   180
ataacagata ttagggtaca aacaagtgag gctgacattt tagaggctgt aaaagaggtt   240
tatgtgtaca atcacatgaa tgttatcgga gcttgtcagc ggatattatt tatcagtcaa   300
tcaccagctt atgataagtt aaataagtgg tttaatatct attctgattt gtattttagc   360
gttgtaccct tgcccaaaat gggggtatat catgagatgg taggtatc                408

<210>   2282
<211>   136
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2282
Met Thr Lys Lys Lys Ile Glu Arg Ile Ser Val Ile His Arg Glu Lys 
1               5                   10                  15      

Ile Leu Trp Leu Lys Trp Tyr Phe Met Arg Asp Lys Glu Gln Pro Lys 
            20                  25                  30          

Tyr Ser Val Leu Glu Arg Lys Met Phe Asp Ala Ala Lys Asn Gln Asp 
        35                  40                  45              

Met Leu Ala Tyr Gln Lys Tyr Ala Thr Ile Lys Gln Ile Thr Asp Ile 
    50                  55                  60                  

Arg Val Gln Thr Ser Glu Ala Asp Ile Leu Glu Ala Val Lys Glu Val 
65                  70                  75                  80  

Tyr Val Tyr Asn His Met Asn Val Ile Gly Ala Cys Gln Arg Ile Leu 
                85                  90                  95      

Phe Ile Ser Gln Ser Pro Ala Tyr Asp Lys Leu Asn Lys Trp Phe Asn 
            100                 105                 110         

Ile Tyr Ser Asp Leu Tyr Phe Ser Val Val Pro Leu Pro Lys Met Gly 
        115                 120                 125             

Val Tyr His Glu Met Val Gly Ile 
    130                 135     

<210>   2283
<211>   363
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2283
gtgcataata tctattttta caaggataaa aacggcaatg agcctgtttt tgattatatg   60
cgagagctta ccagtaaaaa agggaaagat agcagaatta agcttaataa aattaatgat   120
tatattgagt tgttaagcca acatggaaca cgcgcaggcg aaccatatat taagcattta   180
gatgctgaaa tttgggagct gagaccactt agagatagaa ttttatttgt tgcttggatg   240
gatggtagtt ttgttttact gcatcatttt atgaaaagga cacagaaaac acccaaaaga   300
gagattgagc aagctaaacg tgaacttgca gatttaaaag aaagaggttt agacaatgaa   360
aaa                                                                 363

<210>   2284
<211>   121
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2284
Met His Asn Ile Tyr Phe Tyr Lys Asp Lys Asn Gly Asn Glu Pro Val 
1               5                   10                  15      

Phe Asp Tyr Met Arg Glu Leu Thr Ser Lys Lys Gly Lys Asp Ser Arg 
            20                  25                  30          

Ile Lys Leu Asn Lys Ile Asn Asp Tyr Ile Glu Leu Leu Ser Gln His 
        35                  40                  45              

Gly Thr Arg Ala Gly Glu Pro Tyr Ile Lys His Leu Asp Ala Glu Ile 
    50                  55                  60                  

Trp Glu Leu Arg Pro Leu Arg Asp Arg Ile Leu Phe Val Ala Trp Met 
65                  70                  75                  80  

Asp Gly Ser Phe Val Leu Leu His His Phe Met Lys Arg Thr Gln Lys 
                85                  90                  95      

Thr Pro Lys Arg Glu Ile Glu Gln Ala Lys Arg Glu Leu Ala Asp Leu 
            100                 105                 110         

Lys Glu Arg Gly Leu Asp Asn Glu Lys 
        115                 120     

<210>   2285
<211>   291
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2285
atgaaaaata atgctattgg tagtaactgg aaagatgtaa gagctgaatt attcagcaaa   60
gaggaaattt tggaaagtga tatgcgcgtg gctatcatga gtgagcttat cgaggctaga   120
aatgaaaagg gtattagtca gaagaaacta gaggagatga gcggtgttag tcagccagtt   180
atcgctagaa tggaaacagg aaagacaagc ccacaacttg atacagtatt aaaagtgttg   240
gcaagtcttg gtaagacctt agctgttgta ccattagagc atgagcaggt t            291

<210>   2286
<211>   97
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902557 (1.E-34)

<400>   2286
Met Lys Asn Asn Ala Ile Gly Ser Asn Trp Lys Asp Val Arg Ala Glu 
1               5                   10                  15      

Leu Phe Ser Lys Glu Glu Ile Leu Glu Ser Asp Met Arg Val Ala Ile 
            20                  25                  30          

Met Ser Glu Leu Ile Glu Ala Arg Asn Glu Lys Gly Ile Ser Gln Lys 
        35                  40                  45              

Lys Leu Glu Glu Met Ser Gly Val Ser Gln Pro Val Ile Ala Arg Met 
    50                  55                  60                  

Glu Thr Gly Lys Thr Ser Pro Gln Leu Asp Thr Val Leu Lys Val Leu 
65                  70                  75                  80  

Ala Ser Leu Gly Lys Thr Leu Ala Val Val Pro Leu Glu His Glu Gln 
                85                  90                  95      

Val 
    

<210>   2287
<211>   1188
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2287
ttgacagcag aaattggaat attaaataaa aatggtgttg tattggcttc tgatagcgct   60
gtaaccttat cagacgggaa aaattcaaaa gtttttaata gcgcccgaaa attattcact   120
ttatcaaaag aacattccgt ggggatcatg atatatggga acgcttcgtt tatggaaatt   180
ccgtgggagg taattttaaa tgagtttaag caggctattg gcacagattt attagataat   240
actgcccaat acgttgaaaa gctaatagaa tttttaattt cctttaaaca tctacaagtt   300
gaggatttat taagaaatta tattgtcaga agtacaagaa gtattttgga cagcattgcc   360
tatgaagcgc aagaaacagc tgatttaaga gtttctaatg gtgaaaccat cactctagat   420
gattttaata aaattttatt aaatgctata actaatttta gtttagaaat ttcaaaagta   480
gaagctgaaa gtaattttga attttttgaa gctgagttag agttaataaa aagcattgta   540
gacgatgttt ttaaatcctt tcctcatact gatgatgagg ttgaagttat tgctaaatct   600
ttatataaag cgattttcat tggatatgac tcaacaaaca taactggatt agttatagca   660
ggttatggta cagacgagat atttccatct ataagacaaa ttgaattata tggaattttt   720
tctaaacgat taatttggaa agttattaat gaaagtgtga taaatcatca taaaacttgt   780
catataatcc cttttgcaca gtcagagatg gttgagacga ttatgaatgg tatagatcct   840
aacttaaatg tatatatcgc agagcaagta tcatcagtta tggagaaaaa tggattgggt   900
gatgaaattg agaatatatt tgaaaatata tcatctatac agcaaaaata ttatataaat   960
cctataatag accttattgg aatgcaacca cttaatgaaa tggcgagtac agctaaaaca   1020
tttattgaat taacttcatt taagagaaaa attgtcaaca ctcttgaaac agtaggaggt   1080
ccggtagatg tacttgctat ttctaaagga gaaggaccaa tttggattga tagaaaatac   1140
tattttgaca ttgataaaaa tcttgattac aggatgagaa aggagagt                1188

<210>   2288
<211>   396
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2288
Met Thr Ala Glu Ile Gly Ile Leu Asn Lys Asn Gly Val Val Leu Ala 
1               5                   10                  15      

Ser Asp Ser Ala Val Thr Leu Ser Asp Gly Lys Asn Ser Lys Val Phe 
            20                  25                  30          

Asn Ser Ala Arg Lys Leu Phe Thr Leu Ser Lys Glu His Ser Val Gly 
        35                  40                  45              

Ile Met Ile Tyr Gly Asn Ala Ser Phe Met Glu Ile Pro Trp Glu Val 
    50                  55                  60                  

Ile Leu Asn Glu Phe Lys Gln Ala Ile Gly Thr Asp Leu Leu Asp Asn 
65                  70                  75                  80  

Thr Ala Gln Tyr Val Glu Lys Leu Ile Glu Phe Leu Ile Ser Phe Lys 
                85                  90                  95      

His Leu Gln Val Glu Asp Leu Leu Arg Asn Tyr Ile Val Arg Ser Thr 
            100                 105                 110         

Arg Ser Ile Leu Asp Ser Ile Ala Tyr Glu Ala Gln Glu Thr Ala Asp 
        115                 120                 125             

Leu Arg Val Ser Asn Gly Glu Thr Ile Thr Leu Asp Asp Phe Asn Lys 
    130                 135                 140                 

Ile Leu Leu Asn Ala Ile Thr Asn Phe Ser Leu Glu Ile Ser Lys Val 
145                 150                 155                 160 

Glu Ala Glu Ser Asn Phe Glu Phe Phe Glu Ala Glu Leu Glu Leu Ile 
                165                 170                 175     

Lys Ser Ile Val Asp Asp Val Phe Lys Ser Phe Pro His Thr Asp Asp 
            180                 185                 190         

Glu Val Glu Val Ile Ala Lys Ser Leu Tyr Lys Ala Ile Phe Ile Gly 
        195                 200                 205             

Tyr Asp Ser Thr Asn Ile Thr Gly Leu Val Ile Ala Gly Tyr Gly Thr 
    210                 215                 220                 

Asp Glu Ile Phe Pro Ser Ile Arg Gln Ile Glu Leu Tyr Gly Ile Phe 
225                 230                 235                 240 

Ser Lys Arg Leu Ile Trp Lys Val Ile Asn Glu Ser Val Ile Asn His 
                245                 250                 255     

His Lys Thr Cys His Ile Ile Pro Phe Ala Gln Ser Glu Met Val Glu 
            260                 265                 270         

Thr Ile Met Asn Gly Ile Asp Pro Asn Leu Asn Val Tyr Ile Ala Glu 
        275                 280                 285             

Gln Val Ser Ser Val Met Glu Lys Asn Gly Leu Gly Asp Glu Ile Glu 
    290                 295                 300                 

Asn Ile Phe Glu Asn Ile Ser Ser Ile Gln Gln Lys Tyr Tyr Ile Asn 
305                 310                 315                 320 

Pro Ile Ile Asp Leu Ile Gly Met Gln Pro Leu Asn Glu Met Ala Ser 
                325                 330                 335     

Thr Ala Lys Thr Phe Ile Glu Leu Thr Ser Phe Lys Arg Lys Ile Val 
            340                 345                 350         

Asn Thr Leu Glu Thr Val Gly Gly Pro Val Asp Val Leu Ala Ile Ser 
        355                 360                 365             

Lys Gly Glu Gly Pro Ile Trp Ile Asp Arg Lys Tyr Tyr Phe Asp Ile 
    370                 375                 380                 

Asp Lys Asn Leu Asp Tyr Arg Met Arg Lys Glu Ser 
385                 390                 395     

<210>   2289
<211>   174
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2289
atggatttct taaaccattc tttcgatact aaaaaagtta ttaatacaaa aataaatgca   60
gttaactcca aaaataatgt tggaaagaat ttcatcgatg tttaccgtga aatgaaagaa   120
gtgccaaaca ataaaattca tcaatcaaaa gttaacgtgg cgttaattaa aaaa         174

<210>   2290
<211>   58
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2290
Met Asp Phe Leu Asn His Ser Phe Asp Thr Lys Lys Val Ile Asn Thr 
1               5                   10                  15      

Lys Ile Asn Ala Val Asn Ser Lys Asn Asn Val Gly Lys Asn Phe Ile 
            20                  25                  30          

Asp Val Tyr Arg Glu Met Lys Glu Val Pro Asn Asn Lys Ile His Gln 
        35                  40                  45              

Ser Lys Val Asn Val Ala Leu Ile Lys Lys 
    50                  55              

<210>   2291
<211>   378
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2291
atgaggcttt tttgtcttgt tcttgtttca attgactata taaattgtct aagcgaaaca   60
accgataaga attggcacaa aagcgaccgt atttttgtta ccaatacagg aaaaacagtt   120
catagttcta tcttgagcaa gtctctccag cgagcaaacg aacgccttaa aaaaccaatt   180
cccaaacatc tgtcccctca catcttcaga cacaccacta ttagcatctt atcagaaaat   240
aaaattcctt taaaaacaat cacggacagg gttggtcatc ccgactctga agtcactact   300
tccatctaca cccacgtcac aaagaacatg aaagatgaag caatcaatgt actggataaa   360
gttatgaaaa agattttt                                                 378

<210>   2292
<211>   126
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   integrase/recombinase, phage integrase family, truncation
<223>   Cellular location: cytoplasm

<400>   2292
Met Arg Leu Phe Cys Leu Val Leu Val Ser Ile Asp Tyr Ile Asn Cys 
1               5                   10                  15      

Leu Ser Glu Thr Thr Asp Lys Asn Trp His Lys Ser Asp Arg Ile Phe 
            20                  25                  30          

Val Thr Asn Thr Gly Lys Thr Val His Ser Ser Ile Leu Ser Lys Ser 
        35                  40                  45              

Leu Gln Arg Ala Asn Glu Arg Leu Lys Lys Pro Ile Pro Lys His Leu 
    50                  55                  60                  

Ser Pro His Ile Phe Arg His Thr Thr Ile Ser Ile Leu Ser Glu Asn 
65                  70                  75                  80  

Lys Ile Pro Leu Lys Thr Ile Thr Asp Arg Val Gly His Pro Asp Ser 
                85                  90                  95      

Glu Val Thr Thr Ser Ile Tyr Thr His Val Thr Lys Asn Met Lys Asp 
            100                 105                 110         

Glu Ala Ile Asn Val Leu Asp Lys Val Met Lys Lys Ile Phe 
        115                 120                 125     

<210>   2293
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2293
ttggttgcag gtctaacaaa tggtgagtta atcgctccaa tgacttacga agagacgatg   60
acgagcgact tttttgaagc ttggtttcag aagtttctct taccaacatt aaccacacca   120
tcggttatta ttatggataa tgcaagattc catagaatgg ggaagctaga actcttgtgt   180
gaagagtttg ggtataaact tttacctctt cctccctact cacctgagta caatcctatt   240
gagaaaacat gggctcatat caaaaagcac ctcaaaaagg tattaccaag ttgcaatacc   300
ttttatgagg cttttttgtc ttgttcttgt ttcaat                             336

<210>   2294
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903081 (3.E-64)

<400>   2294
Met Val Ala Gly Leu Thr Asn Gly Glu Leu Ile Ala Pro Met Thr Tyr 
1               5                   10                  15      

Glu Glu Thr Met Thr Ser Asp Phe Phe Glu Ala Trp Phe Gln Lys Phe 
            20                  25                  30          

Leu Leu Pro Thr Leu Thr Thr Pro Ser Val Ile Ile Met Asp Asn Ala 
        35                  40                  45              

Arg Phe His Arg Met Gly Lys Leu Glu Leu Leu Cys Glu Glu Phe Gly 
    50                  55                  60                  

Tyr Lys Leu Leu Pro Leu Pro Pro Tyr Ser Pro Glu Tyr Asn Pro Ile 
65                  70                  75                  80  

Glu Lys Thr Trp Ala His Ile Lys Lys His Leu Lys Lys Val Leu Pro 
                85                  90                  95      

Ser Cys Asn Thr Phe Tyr Glu Ala Phe Leu Ser Cys Ser Cys Phe Asn 
            100                 105                 110         


<210>   2295
<211>   414
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2295
atgtggtata atcttcttat ggcatattca atagattttc gtaaaaaagt tctctcttat   60
tgtgagcgaa caggtagtat aacagaagca tcacacgttt tccaaatctc acgtaatacc   120
atttatggct ggttaaagct aaaagagaaa acaggagagc taaaccacca agtaaaagga   180
acaaaaccaa gaaaagttga tagagataga cttaaaaact atcttactga caatccagat   240
gcttatttga ctgaaatagc ttctgacttt ggctgtcatc caactaccat ccactatgcg   300
ctcaaagcta tgggctacac tcgaaaaaag aaccacacct actatgaaca agacccagaa   360
aaagtagcct tatttcttaa gaattttaat agtttaaagc acctaacacc tgtt         414

<210>   2296
<211>   138
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1 FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902766 (5.E-63)

<400>   2296
Met Trp Tyr Asn Leu Leu Met Ala Tyr Ser Ile Asp Phe Arg Lys Lys 
1               5                   10                  15      

Val Leu Ser Tyr Cys Glu Arg Thr Gly Ser Ile Thr Glu Ala Ser His 
            20                  25                  30          

Val Phe Gln Ile Ser Arg Asn Thr Ile Tyr Gly Trp Leu Lys Leu Lys 
        35                  40                  45              

Glu Lys Thr Gly Glu Leu Asn His Gln Val Lys Gly Thr Lys Pro Arg 
    50                  55                  60                  

Lys Val Asp Arg Asp Arg Leu Lys Asn Tyr Leu Thr Asp Asn Pro Asp 
65                  70                  75                  80  

Ala Tyr Leu Thr Glu Ile Ala Ser Asp Phe Gly Cys His Pro Thr Thr 
                85                  90                  95      

Ile His Tyr Ala Leu Lys Ala Met Gly Tyr Thr Arg Lys Lys Asn His 
            100                 105                 110         

Thr Tyr Tyr Glu Gln Asp Pro Glu Lys Val Ala Leu Phe Leu Lys Asn 
        115                 120                 125             

Phe Asn Ser Leu Lys His Leu Thr Pro Val 
    130                 135             

<210>   2297
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2297
ttggaatttt tcatcaccct atattatacc atgattagcc tcgtaaatct gttaaaatat   60
ttaggccatc ctttcttttc ttcatcatct gctaaatct                          99

<210>   2298
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2298
Met Glu Phe Phe Ile Thr Leu Tyr Tyr Thr Met Ile Ser Leu Val Asn 
1               5                   10                  15      

Leu Leu Lys Tyr Leu Gly His Pro Phe Phe Ser Ser Ser Ser Ala Lys 
            20                  25                  30          

Ser 
    

<210>   2299
<211>   3300
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2299
gtgatgaaaa attccaacga ggctgagatg aaattacttt atactgatat tcggacttct   60
ttgacagaaa ttctaacaag agaggcagaa gagctagttg cagctggcaa gcgggtcttc   120
tacattgccc ccaactctct ttcttttgaa aaggaacgcg ccgtgctgga atacttgtcc   180
cagcaggctt ctttttcgat taccgtcacg cgctttgctc aaatggctcg ctatctggtc   240
ttgaatgatt taccagctaa aactactctt gatgatatcg gtcttgggtt ggccttttac   300
aaatgccttg ccgaactcga tcccaaggac ttgcgtgttt atggcgctat taagcaggat   360
cctcaattga tccagcagtt aattgagctt taccatgaga tgaccaaatc tcagatgagt   420
tttttggact tggagaattt aacagatgag gataagaggg cggatttact cttgattttt   480
gagaaagtaa cagcctatct taatcaaggt cagttagccc aggaaagtca gttgtcccat   540
ttgattgagg ctattgagaa tgacaaggta agtagtgatt ttaatcaaat cgccttggtc   600
attgacggct ttactcgttt ttctgctgag gaagagcggg ttgtggactt acttcacggc   660
aaaggtgttg agattgttat cggggcttat gctagtaaga aagcctatac cagtcctttt   720
agcgagggca atctctacca agccagcgta aaatttctcc atcatctggc ttctaaatac   780
caaacgcctg ctcaggactg ttctcaaact catgagaaga tggatagttt tgacaaggcc   840
tctcgtttgt tggagtcttc ttatgacttt tcagaactcg ctttggatgt cgatgagaaa   900
gaccgtgaaa atttacaaat ctggtcttgt ttgacgcaaa aggaggagtt ggagctagta   960
gcccgtagta ttcgtcagaa attacatgag aactcagacc tgagctacaa gcattttcgt   1020
attctcttgg gggatgtagc ttcttaccag ttatctctca aaaccatttt tgaccagtat   1080
cagattcctt tttatcttgg tagaagcgaa gccatggctc atcatccctt gactcagttt   1140
gtcgagtcta ttttagcttt aaaacgttac cgttttcgtc aggaggattt gattaatctt   1200
cttagaactg atttgtatac tgacctcagt cagtctgata ttgatgcttt tgagcaatat   1260
atccgctatc ttggtatcaa tggcttgcca gcctttcagc aaaccttcac caaatcccac   1320
catggaaaat ttaatcttga gcgtttgaat gtcctccgcc tgagaatttt agcacctctt   1380
gaaaccctct ttgccagccg aaaacaaaag gctgaaaaac tcctacaaaa atggagtgtc   1440
tttctaaaag aaggagctgt gaccaagcag ttacaagatt tgacaaccac tttggaagct   1500
gtagaacagg aaagacaagc cgaagtttgg aaggctttct gccatgtttt agaacaattt   1560
gcgactgttt ttgctggttc acaggttagt ctggaagact tcctagcctt gctccattct   1620
ggaatgagtt tgtcccaata ccgtaccatt ccagcaacag tggacactgt tctggtgcag   1680
agttacgatt tgattgcacc attgactgct gactttgtct atgctattgg actaactcag   1740
gacaatttac caaaaatttc tcaaaacacc agtcttctga cagatgaaga aaggcaaaac   1800
ctaaaccaag cgaccgaaga aggcgttcaa ttactgattg ccagcagtga aaatctcaag   1860
aaaaatcgct acactatgct ttccttggtc aattctgctc gtaagcagtt gttcttgtcg   1920
gctccaagcc tttttaacga aagtgaaagt aaggaatctg cctatcttca agagttgatc   1980
cattttggat ttaggcggag agagaagagg atgaatcaca aaggactgtc taaggaggat   2040
atggggtcct atcacagtct tttgtctagt ctggttgcct atcaccagca gggtgagatg   2100
agcgatactg agcaagattt gacttttgtc aaggttctgt cgcgtgtcat aggtaaaaaa   2160
ctagatcagc aaggtctgga aaatccagct atcccaacca gtccaagcag caagacctta   2220
gccaaggaca ccttgcaagc tctctatcct gccaaacagg agttttacct gtctacgtcg   2280
ggtttgacag agttttatcg caatgaatac agttatttcc tacgctacgt tttaggcttg   2340
caggaggaat tacgtttgca tcctgatgcc cgtagtcacg ggaatttctt gcatcgtatc   2400
tttgaacgcg ccttacagtt gcctaatgaa gattcctttg accaacgtct agaacaagct   2460
attcaagaaa ccagtcaaga acgcgaattt gaagctattt atcaagaaag tttggaagcc   2520
cagtttacca aggaagtttt gcttgatgtt gcacggacaa ctggacatat tctccgacac   2580
aatccagcca tcgaaaccat caaagaagaa gcaaattttg gtggaaaaga ccaagccttt   2640
attcaattag acaatggacg cagtgtcttt gtacgaggca aggtggaccg gattgaccgt   2700
ttgaaagcta atggagcgat aggagtagta gactacaaat ccagtctgac tcagttccag   2760
tttcctcatt tctttaatgg gctcaattct cagttaccaa cctatcttgc tgccctaaaa   2820
agagaagggg agcagaactt tttcggcgcc atgtacttgg aaatggctga acctgtccaa   2880
tctctgatgg cggtaaaaag tctggcagga gcagtggtag aagccagcaa atctatgaaa   2940
taccaagggc tcttcttgga aaaagaaagc agttatttag gcgaatttta taacaaaaac   3000
aaggctaatc aactgacaga tgaggaattt cagctcctac tggactacaa tgcctatctt   3060
tacaagaaag ctgctgagaa gattttagca ggccggttcg ccatcaatcc ttatactgaa   3120
aatggcagaa gcattgcccc atacgtccag caacatcagg ctattacagg ctttgaagcc   3180
aattaccatc tgggccaagc ccgtttccta gaaaagttgg acctagctga tggcaagcgt   3240
ctggtcggag aaaaactcaa gcaagcttgg cttgaaaaaa taagagagga gttgaatcga   3300

<210>   2300
<211>   1100
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   exonuclease RexB (rexB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903083 (0.E+01)

<400>   2300
Met Met Lys Asn Ser Asn Glu Ala Glu Met Lys Leu Leu Tyr Thr Asp 
1               5                   10                  15      

Ile Arg Thr Ser Leu Thr Glu Ile Leu Thr Arg Glu Ala Glu Glu Leu 
            20                  25                  30          

Val Ala Ala Gly Lys Arg Val Phe Tyr Ile Ala Pro Asn Ser Leu Ser 
        35                  40                  45              

Phe Glu Lys Glu Arg Ala Val Leu Glu Tyr Leu Ser Gln Gln Ala Ser 
    50                  55                  60                  

Phe Ser Ile Thr Val Thr Arg Phe Ala Gln Met Ala Arg Tyr Leu Val 
65                  70                  75                  80  

Leu Asn Asp Leu Pro Ala Lys Thr Thr Leu Asp Asp Ile Gly Leu Gly 
                85                  90                  95      

Leu Ala Phe Tyr Lys Cys Leu Ala Glu Leu Asp Pro Lys Asp Leu Arg 
            100                 105                 110         

Val Tyr Gly Ala Ile Lys Gln Asp Pro Gln Leu Ile Gln Gln Leu Ile 
        115                 120                 125             

Glu Leu Tyr His Glu Met Thr Lys Ser Gln Met Ser Phe Leu Asp Leu 
    130                 135                 140                 

Glu Asn Leu Thr Asp Glu Asp Lys Arg Ala Asp Leu Leu Leu Ile Phe 
145                 150                 155                 160 

Glu Lys Val Thr Ala Tyr Leu Asn Gln Gly Gln Leu Ala Gln Glu Ser 
                165                 170                 175     

Gln Leu Ser His Leu Ile Glu Ala Ile Glu Asn Asp Lys Val Ser Ser 
            180                 185                 190         

Asp Phe Asn Gln Ile Ala Leu Val Ile Asp Gly Phe Thr Arg Phe Ser 
        195                 200                 205             

Ala Glu Glu Glu Arg Val Val Asp Leu Leu His Gly Lys Gly Val Glu 
    210                 215                 220                 

Ile Val Ile Gly Ala Tyr Ala Ser Lys Lys Ala Tyr Thr Ser Pro Phe 
225                 230                 235                 240 

Ser Glu Gly Asn Leu Tyr Gln Ala Ser Val Lys Phe Leu His His Leu 
                245                 250                 255     

Ala Ser Lys Tyr Gln Thr Pro Ala Gln Asp Cys Ser Gln Thr His Glu 
            260                 265                 270         

Lys Met Asp Ser Phe Asp Lys Ala Ser Arg Leu Leu Glu Ser Ser Tyr 
        275                 280                 285             

Asp Phe Ser Glu Leu Ala Leu Asp Val Asp Glu Lys Asp Arg Glu Asn 
    290                 295                 300                 

Leu Gln Ile Trp Ser Cys Leu Thr Gln Lys Glu Glu Leu Glu Leu Val 
305                 310                 315                 320 

Ala Arg Ser Ile Arg Gln Lys Leu His Glu Asn Ser Asp Leu Ser Tyr 
                325                 330                 335     

Lys His Phe Arg Ile Leu Leu Gly Asp Val Ala Ser Tyr Gln Leu Ser 
            340                 345                 350         

Leu Lys Thr Ile Phe Asp Gln Tyr Gln Ile Pro Phe Tyr Leu Gly Arg 
        355                 360                 365             

Ser Glu Ala Met Ala His His Pro Leu Thr Gln Phe Val Glu Ser Ile 
    370                 375                 380                 

Leu Ala Leu Lys Arg Tyr Arg Phe Arg Gln Glu Asp Leu Ile Asn Leu 
385                 390                 395                 400 

Leu Arg Thr Asp Leu Tyr Thr Asp Leu Ser Gln Ser Asp Ile Asp Ala 
                405                 410                 415     

Phe Glu Gln Tyr Ile Arg Tyr Leu Gly Ile Asn Gly Leu Pro Ala Phe 
            420                 425                 430         

Gln Gln Thr Phe Thr Lys Ser His His Gly Lys Phe Asn Leu Glu Arg 
        435                 440                 445             

Leu Asn Val Leu Arg Leu Arg Ile Leu Ala Pro Leu Glu Thr Leu Phe 
    450                 455                 460                 

Ala Ser Arg Lys Gln Lys Ala Glu Lys Leu Leu Gln Lys Trp Ser Val 
465                 470                 475                 480 

Phe Leu Lys Glu Gly Ala Val Thr Lys Gln Leu Gln Asp Leu Thr Thr 
                485                 490                 495     

Thr Leu Glu Ala Val Glu Gln Glu Arg Gln Ala Glu Val Trp Lys Ala 
            500                 505                 510         

Phe Cys His Val Leu Glu Gln Phe Ala Thr Val Phe Ala Gly Ser Gln 
        515                 520                 525             

Val Ser Leu Glu Asp Phe Leu Ala Leu Leu His Ser Gly Met Ser Leu 
    530                 535                 540                 

Ser Gln Tyr Arg Thr Ile Pro Ala Thr Val Asp Thr Val Leu Val Gln 
545                 550                 555                 560 

Ser Tyr Asp Leu Ile Ala Pro Leu Thr Ala Asp Phe Val Tyr Ala Ile 
                565                 570                 575     

Gly Leu Thr Gln Asp Asn Leu Pro Lys Ile Ser Gln Asn Thr Ser Leu 
            580                 585                 590         

Leu Thr Asp Glu Glu Arg Gln Asn Leu Asn Gln Ala Thr Glu Glu Gly 
        595                 600                 605             

Val Gln Leu Leu Ile Ala Ser Ser Glu Asn Leu Lys Lys Asn Arg Tyr 
    610                 615                 620                 

Thr Met Leu Ser Leu Val Asn Ser Ala Arg Lys Gln Leu Phe Leu Ser 
625                 630                 635                 640 

Ala Pro Ser Leu Phe Asn Glu Ser Glu Ser Lys Glu Ser Ala Tyr Leu 
                645                 650                 655     

Gln Glu Leu Ile His Phe Gly Phe Arg Arg Arg Glu Lys Arg Met Asn 
            660                 665                 670         

His Lys Gly Leu Ser Lys Glu Asp Met Gly Ser Tyr His Ser Leu Leu 
        675                 680                 685             

Ser Ser Leu Val Ala Tyr His Gln Gln Gly Glu Met Ser Asp Thr Glu 
    690                 695                 700                 

Gln Asp Leu Thr Phe Val Lys Val Leu Ser Arg Val Ile Gly Lys Lys 
705                 710                 715                 720 

Leu Asp Gln Gln Gly Leu Glu Asn Pro Ala Ile Pro Thr Ser Pro Ser 
                725                 730                 735     

Ser Lys Thr Leu Ala Lys Asp Thr Leu Gln Ala Leu Tyr Pro Ala Lys 
            740                 745                 750         

Gln Glu Phe Tyr Leu Ser Thr Ser Gly Leu Thr Glu Phe Tyr Arg Asn 
        755                 760                 765             

Glu Tyr Ser Tyr Phe Leu Arg Tyr Val Leu Gly Leu Gln Glu Glu Leu 
    770                 775                 780                 

Arg Leu His Pro Asp Ala Arg Ser His Gly Asn Phe Leu His Arg Ile 
785                 790                 795                 800 

Phe Glu Arg Ala Leu Gln Leu Pro Asn Glu Asp Ser Phe Asp Gln Arg 
                805                 810                 815     

Leu Glu Gln Ala Ile Gln Glu Thr Ser Gln Glu Arg Glu Phe Glu Ala 
            820                 825                 830         

Ile Tyr Gln Glu Ser Leu Glu Ala Gln Phe Thr Lys Glu Val Leu Leu 
        835                 840                 845             

Asp Val Ala Arg Thr Thr Gly His Ile Leu Arg His Asn Pro Ala Ile 
    850                 855                 860                 

Glu Thr Ile Lys Glu Glu Ala Asn Phe Gly Gly Lys Asp Gln Ala Phe 
865                 870                 875                 880 

Ile Gln Leu Asp Asn Gly Arg Ser Val Phe Val Arg Gly Lys Val Asp 
                885                 890                 895     

Arg Ile Asp Arg Leu Lys Ala Asn Gly Ala Ile Gly Val Val Asp Tyr 
            900                 905                 910         

Lys Ser Ser Leu Thr Gln Phe Gln Phe Pro His Phe Phe Asn Gly Leu 
        915                 920                 925             

Asn Ser Gln Leu Pro Thr Tyr Leu Ala Ala Leu Lys Arg Glu Gly Glu 
    930                 935                 940                 

Gln Asn Phe Phe Gly Ala Met Tyr Leu Glu Met Ala Glu Pro Val Gln 
945                 950                 955                 960 

Ser Leu Met Ala Val Lys Ser Leu Ala Gly Ala Val Val Glu Ala Ser 
                965                 970                 975     

Lys Ser Met Lys Tyr Gln Gly Leu Phe Leu Glu Lys Glu Ser Ser Tyr 
            980                 985                 990         

Leu Gly Glu Phe Tyr Asn Lys Asn Lys Ala Asn Gln Leu Thr Asp Glu 
        995                 1000                1005            

Glu Phe Gln Leu Leu Leu Asp Tyr Asn Ala Tyr Leu Tyr Lys Lys Ala 
    1010                1015                1020                

Ala Glu Lys Ile Leu Ala Gly Arg Phe Ala Ile Asn Pro Tyr Thr Glu 
1025                1030                1035                1040

Asn Gly Arg Ser Ile Ala Pro Tyr Val Gln Gln His Gln Ala Ile Thr 
                1045                1050                1055    

Gly Phe Glu Ala Asn Tyr His Leu Gly Gln Ala Arg Phe Leu Glu Lys 
            1060                1065                1070        

Leu Asp Leu Ala Asp Gly Lys Arg Leu Val Gly Glu Lys Leu Lys Gln 
        1075                1080                1085            

Ala Trp Leu Glu Lys Ile Arg Glu Glu Leu Asn Arg 
    1090                1095                1100

<210>   2301
<211>   3648
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2301
atgaagctta ttcccttttt aagtgaggag gagattcaaa aactgcaaga agcagaagca   60
aattcgagca aggaacagaa gaaaactgcc gagcaaatcg aagctatcta cacttctgcc   120
cagaatatcc tggtctcagc atcggctggt tctggaaaga cctttgtcat ggcagagcgc   180
attctggacc aattggcgcg tggtgtcgaa atttctcaac tctttatctc aacctttacc   240
gtcaaggctg caactgaact taaagaacgt ttagagaaaa aaatcagcaa gaaaatccaa   300
gaaacagatg atgtcgacct caaacaacac ttgggtcgcc agttggcaga cctacccaac   360
gctgccattg gaaccatgga ttctttcaca caaaaattcc ttggcaaaca tggttatctg   420
cttgatattg cacctaattt ccgtatttta caaaaccaaa gcgagcaact tattctcgaa   480
aacgaagtct ttcatgaggt ctttgaagcg cattaccaag gtaaacagaa agagaccttt   540
agtcatttgc tgaaaaactt tgctgggcgt ggcaaggacg aacggggtct gcgccagcag   600
gtctataaaa tctatgactt cctccaatcc accagtaatc ctcaaaagtg gctgagtgaa   660
tctttcctca aaggatttga gaaagctgat tttaccagtg aaaaagaaaa actgaccgag   720
caaatcaaac aagccctttg ggatttggaa agctttttcc gttaccatct ggataacgat   780
gccaaggagt ttgcaaaggc tgcctattta gaaaatgttc agttaattct ggatgaaatt   840
ggctccctaa atcaggagtc cgatagtcag gcttatcagg cagtgcttgc gcgtgttgtc   900
gccatctcta aggagaaaaa cggtcgagct ctgactaatg ccagccgtaa ggctgatttg   960
aagcccctgg ctgatgccta caacgaagag agaaagaccc agtttgctaa actaggacaa   1020
ttatcagacc agatagcgat tctcgactat caagaacgtt atcatggaga cacttggaaa   1080
ctagctaaaa ccttccaatc tttcatgagc gattttgtag aggcttatcg tcagagaaaa   1140
cgacaggaaa atgccttcga attcgctgat atcagccatt acaccattga gattttagag   1200
aatttcccac aagttcgtga gtcttatcag gagcgcttcc atgaagtcat ggtcgatgag   1260
tatcaggata ccaaccatat tcaagaacgg atgctggaat tgttgtctaa tggccacaat   1320
cgctttatgg tgggagatat caagcaatcc atctatcgtt tccgtcaggc agacccgcag   1380
attttcaatg agaaattcca acgctatgcg caaaatcccc aagaaggcag gctcattatc   1440
ctcaaggaaa atttccgtag tagttcagaa gtgctgtcag caaccaatga tgtctttgaa   1500
cgtctcatgg accaagaggt cggcgaaatc aactatgata acaagcacca gcttgttttt   1560
gccaatacca aactgactcc caatccagac aacaaggcag catttctcct ctacgacaag   1620
gacgatacag gtgaggaaga agagagtcaa acagaaacga aactaacagg cgaaatgcgc   1680
ttagttatca aggagattct gaaacttcat caagaaaaag gtgttgcctt taaggaaatt   1740
gcccttctga cctccagccg cagtcgtaat gaccagattc tcctcgccct gtctgagtac   1800
ggaattcctg tcaaaactga cggagagcaa aacaattatc tccaatccct agaagtgcaa   1860
gtcatgctag acactcttcg tgtcattcac aatcccctgc aagactacgc cttggttgcc   1920
cttatgaagt ctccaatgtt tggttttgat gaggatgagc tagcacgttt gtcccttcag   1980
aaagcagagg ataaagtcca cgaaaatctc tatgagaaac tggtcaatgc acaaaaaatg   2040
gcaagtagtc aaaaaggctt gattcacaca gctctagctg aaaaactaaa gcaattcatg   2100
gatatcctag cttcttggcg cttgtatgcc aaaacccact ctctctatga cttgatttgg   2160
aagatttaca acgaccgttt ttattatgac tatgttgggg ctttgccgaa tggtcctgct   2220
aggcaggcca atctctatgc cctagcactg cgtgctgatc aatttgaaaa gagcaatttc   2280
aaaggtttgt cgcgttttat tcgtatgatt gaccaagtct tagaagccca gcacgatttg   2340
gcaagcgtgg ccgtcgcacc gccaaaagat gcagtagagc tcatgaccat ccacaagagt   2400
aaagggctgg agtttcctta cgtctttatc ctcaatatgg atcaagattt caacaagcaa   2460
gactctatgt cagaagtcat tctcagtcgt cagaatggtc ttggtgtcaa atatattgcc   2520
aagatggaga caggggcagt agaagaccac tatcctaaaa ccatcaaact ctccattcct   2580
agtctgacct ataggcagaa cgaagaggaa ttacagctag caagctattc tgagcagatg   2640
cgtttgctgt atgttgctat gacgcgggct gagaaaaagc tctatcttgt cggcaagggt   2700
tctcgtgaaa agctggaatc caaggaatac ccagcagcca aaaatgggaa actaaatagc   2760
aatactagac tgcaagcacg gaatttccaa gattggcttt gggctatcag taaagtgttt   2820
actaaggaca agctcaactt tagttatcgt tttattggcg aagatcagtt gaccagagaa   2880
gctatcggag agttggaaac caagagtcct ctccaagata gctcccaagc agacaatcgt   2940
cagtcagata ccatcaaaga agctctggaa atgctgaagg aggtggaagt ttataatact   3000
cttcaccgcg cagctattga acttcctagt gttcaaaccc caagtcaaat caagaaattc   3060
tacgaaccag ttatggatat ggaaggtgtc gagattgctg gtcaaggtca gtcagtaggc   3120
aagaaaatca gcttcgattt gccagatttt tcaaccaaag aaaaggtaac tggagctgag   3180
attggtagtg ctactcacga actcatgcag agaattgacc tcagccagca actaaccctt   3240
gctagcctaa cagaaacact caaacaagtt caaactagcc aagctgtcag agacaagatc   3300
aatcttgata aaattcttgc tttctttgac acagtactcg gtcaggaaat tcttgctaat   3360
accgaccatc tttatcgcga gcaacctttc tccatgctca aacgagacca aaagagtcag   3420
gaagactttg ttgtccgtgg tatccttgat ggctatctgc tttacgaaaa caaaattgtt   3480
ctgttcgact acaagacaga ccgctatgat gaaccaagtc aactcgtaga ccgctatcgt   3540
ggtcagttag ctctatacga agaggcttta tcacgagcct attcgattga aaatattgaa   3600
aaatacttga ttttactcgg taaagacgag gttcaagttg taaaagta                3648

<210>   2302
<211>   1216
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   exonuclease RexA (rexA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903084 (0.E+01)

<400>   2302
Met Lys Leu Ile Pro Phe Leu Ser Glu Glu Glu Ile Gln Lys Leu Gln 
1               5                   10                  15      

Glu Ala Glu Ala Asn Ser Ser Lys Glu Gln Lys Lys Thr Ala Glu Gln 
            20                  25                  30          

Ile Glu Ala Ile Tyr Thr Ser Ala Gln Asn Ile Leu Val Ser Ala Ser 
        35                  40                  45              

Ala Gly Ser Gly Lys Thr Phe Val Met Ala Glu Arg Ile Leu Asp Gln 
    50                  55                  60                  

Leu Ala Arg Gly Val Glu Ile Ser Gln Leu Phe Ile Ser Thr Phe Thr 
65                  70                  75                  80  

Val Lys Ala Ala Thr Glu Leu Lys Glu Arg Leu Glu Lys Lys Ile Ser 
                85                  90                  95      

Lys Lys Ile Gln Glu Thr Asp Asp Val Asp Leu Lys Gln His Leu Gly 
            100                 105                 110         

Arg Gln Leu Ala Asp Leu Pro Asn Ala Ala Ile Gly Thr Met Asp Ser 
        115                 120                 125             

Phe Thr Gln Lys Phe Leu Gly Lys His Gly Tyr Leu Leu Asp Ile Ala 
    130                 135                 140                 

Pro Asn Phe Arg Ile Leu Gln Asn Gln Ser Glu Gln Leu Ile Leu Glu 
145                 150                 155                 160 

Asn Glu Val Phe His Glu Val Phe Glu Ala His Tyr Gln Gly Lys Gln 
                165                 170                 175     

Lys Glu Thr Phe Ser His Leu Leu Lys Asn Phe Ala Gly Arg Gly Lys 

            180                 185                 190         

Asp Glu Arg Gly Leu Arg Gln Gln Val Tyr Lys Ile Tyr Asp Phe Leu 
        195                 200                 205             

Gln Ser Thr Ser Asn Pro Gln Lys Trp Leu Ser Glu Ser Phe Leu Lys 
    210                 215                 220                 

Gly Phe Glu Lys Ala Asp Phe Thr Ser Glu Lys Glu Lys Leu Thr Glu 
225                 230                 235                 240 

Gln Ile Lys Gln Ala Leu Trp Asp Leu Glu Ser Phe Phe Arg Tyr His 
                245                 250                 255     

Leu Asp Asn Asp Ala Lys Glu Phe Ala Lys Ala Ala Tyr Leu Glu Asn 
            260                 265                 270         

Val Gln Leu Ile Leu Asp Glu Ile Gly Ser Leu Asn Gln Glu Ser Asp 
        275                 280                 285             

Ser Gln Ala Tyr Gln Ala Val Leu Ala Arg Val Val Ala Ile Ser Lys 
    290                 295                 300                 

Glu Lys Asn Gly Arg Ala Leu Thr Asn Ala Ser Arg Lys Ala Asp Leu 
305                 310                 315                 320 

Lys Pro Leu Ala Asp Ala Tyr Asn Glu Glu Arg Lys Thr Gln Phe Ala 
                325                 330                 335     

Lys Leu Gly Gln Leu Ser Asp Gln Ile Ala Ile Leu Asp Tyr Gln Glu 
            340                 345                 350         

Arg Tyr His Gly Asp Thr Trp Lys Leu Ala Lys Thr Phe Gln Ser Phe 
        355                 360                 365             

Met Ser Asp Phe Val Glu Ala Tyr Arg Gln Arg Lys Arg Gln Glu Asn 
    370                 375                 380                 

Ala Phe Glu Phe Ala Asp Ile Ser His Tyr Thr Ile Glu Ile Leu Glu 
385                 390                 395                 400 

Asn Phe Pro Gln Val Arg Glu Ser Tyr Gln Glu Arg Phe His Glu Val 
                405                 410                 415     

Met Val Asp Glu Tyr Gln Asp Thr Asn His Ile Gln Glu Arg Met Leu 
            420                 425                 430         

Glu Leu Leu Ser Asn Gly His Asn Arg Phe Met Val Gly Asp Ile Lys 
        435                 440                 445             

Gln Ser Ile Tyr Arg Phe Arg Gln Ala Asp Pro Gln Ile Phe Asn Glu 
    450                 455                 460                 

Lys Phe Gln Arg Tyr Ala Gln Asn Pro Gln Glu Gly Arg Leu Ile Ile 
465                 470                 475                 480 

Leu Lys Glu Asn Phe Arg Ser Ser Ser Glu Val Leu Ser Ala Thr Asn 
                485                 490                 495     

Asp Val Phe Glu Arg Leu Met Asp Gln Glu Val Gly Glu Ile Asn Tyr 
            500                 505                 510         

Asp Asn Lys His Gln Leu Val Phe Ala Asn Thr Lys Leu Thr Pro Asn 
        515                 520                 525             

Pro Asp Asn Lys Ala Ala Phe Leu Leu Tyr Asp Lys Asp Asp Thr Gly 
    530                 535                 540                 

Glu Glu Glu Glu Ser Gln Thr Glu Thr Lys Leu Thr Gly Glu Met Arg 
545                 550                 555                 560 

Leu Val Ile Lys Glu Ile Leu Lys Leu His Gln Glu Lys Gly Val Ala 
                565                 570                 575     

Phe Lys Glu Ile Ala Leu Leu Thr Ser Ser Arg Ser Arg Asn Asp Gln 
            580                 585                 590         

Ile Leu Leu Ala Leu Ser Glu Tyr Gly Ile Pro Val Lys Thr Asp Gly 
        595                 600                 605             

Glu Gln Asn Asn Tyr Leu Gln Ser Leu Glu Val Gln Val Met Leu Asp 
    610                 615                 620                 

Thr Leu Arg Val Ile His Asn Pro Leu Gln Asp Tyr Ala Leu Val Ala 
625                 630                 635                 640 

Leu Met Lys Ser Pro Met Phe Gly Phe Asp Glu Asp Glu Leu Ala Arg 
                645                 650                 655     

Leu Ser Leu Gln Lys Ala Glu Asp Lys Val His Glu Asn Leu Tyr Glu 
            660                 665                 670         

Lys Leu Val Asn Ala Gln Lys Met Ala Ser Ser Gln Lys Gly Leu Ile 
        675                 680                 685             

His Thr Ala Leu Ala Glu Lys Leu Lys Gln Phe Met Asp Ile Leu Ala 
    690                 695                 700                 

Ser Trp Arg Leu Tyr Ala Lys Thr His Ser Leu Tyr Asp Leu Ile Trp 
705                 710                 715                 720 

Lys Ile Tyr Asn Asp Arg Phe Tyr Tyr Asp Tyr Val Gly Ala Leu Pro 
                725                 730                 735     

Asn Gly Pro Ala Arg Gln Ala Asn Leu Tyr Ala Leu Ala Leu Arg Ala 
            740                 745                 750         

Asp Gln Phe Glu Lys Ser Asn Phe Lys Gly Leu Ser Arg Phe Ile Arg 
        755                 760                 765             

Met Ile Asp Gln Val Leu Glu Ala Gln His Asp Leu Ala Ser Val Ala 
    770                 775                 780                 

Val Ala Pro Pro Lys Asp Ala Val Glu Leu Met Thr Ile His Lys Ser 
785                 790                 795                 800 

Lys Gly Leu Glu Phe Pro Tyr Val Phe Ile Leu Asn Met Asp Gln Asp 
                805                 810                 815     

Phe Asn Lys Gln Asp Ser Met Ser Glu Val Ile Leu Ser Arg Gln Asn 
            820                 825                 830         

Gly Leu Gly Val Lys Tyr Ile Ala Lys Met Glu Thr Gly Ala Val Glu 
        835                 840                 845             

Asp His Tyr Pro Lys Thr Ile Lys Leu Ser Ile Pro Ser Leu Thr Tyr 
    850                 855                 860                 

Arg Gln Asn Glu Glu Glu Leu Gln Leu Ala Ser Tyr Ser Glu Gln Met 
865                 870                 875                 880 

Arg Leu Leu Tyr Val Ala Met Thr Arg Ala Glu Lys Lys Leu Tyr Leu 
                885                 890                 895     

Val Gly Lys Gly Ser Arg Glu Lys Leu Glu Ser Lys Glu Tyr Pro Ala 
            900                 905                 910         

Ala Lys Asn Gly Lys Leu Asn Ser Asn Thr Arg Leu Gln Ala Arg Asn 
        915                 920                 925             

Phe Gln Asp Trp Leu Trp Ala Ile Ser Lys Val Phe Thr Lys Asp Lys 
    930                 935                 940                 

Leu Asn Phe Ser Tyr Arg Phe Ile Gly Glu Asp Gln Leu Thr Arg Glu 
945                 950                 955                 960 

Ala Ile Gly Glu Leu Glu Thr Lys Ser Pro Leu Gln Asp Ser Ser Gln 
                965                 970                 975     

Ala Asp Asn Arg Gln Ser Asp Thr Ile Lys Glu Ala Leu Glu Met Leu 
            980                 985                 990         

Lys Glu Val Glu Val Tyr Asn Thr Leu His Arg Ala Ala Ile Glu Leu 
        995                 1000                1005            

Pro Ser Val Gln Thr Pro Ser Gln Ile Lys Lys Phe Tyr Glu Pro Val 
    1010                1015                1020                

Met Asp Met Glu Gly Val Glu Ile Ala Gly Gln Gly Gln Ser Val Gly 
1025                1030                1035                1040


Lys Lys Ile Ser Phe Asp Leu Pro Asp Phe Ser Thr Lys Glu Lys Val 
                1045                1050                1055    

Thr Gly Ala Glu Ile Gly Ser Ala Thr His Glu Leu Met Gln Arg Ile 
            1060                1065                1070        

Asp Leu Ser Gln Gln Leu Thr Leu Ala Ser Leu Thr Glu Thr Leu Lys 
        1075                1080                1085            

Gln Val Gln Thr Ser Gln Ala Val Arg Asp Lys Ile Asn Leu Asp Lys 
    1090                1095                1100                

Ile Leu Ala Phe Phe Asp Thr Val Leu Gly Gln Glu Ile Leu Ala Asn 
1105                1110                1115                1120

Thr Asp His Leu Tyr Arg Glu Gln Pro Phe Ser Met Leu Lys Arg Asp 
                1125                1130                1135    

Gln Lys Ser Gln Glu Asp Phe Val Val Arg Gly Ile Leu Asp Gly Tyr 
            1140                1145                1150        

Leu Leu Tyr Glu Asn Lys Ile Val Leu Phe Asp Tyr Lys Thr Asp Arg 
        1155                1160                1165            

Tyr Asp Glu Pro Ser Gln Leu Val Asp Arg Tyr Arg Gly Gln Leu Ala 
    1170                1175                1180                

Leu Tyr Glu Glu Ala Leu Ser Arg Ala Tyr Ser Ile Glu Asn Ile Glu 
1185                1190                1195                1200

Lys Tyr Leu Ile Leu Leu Gly Lys Asp Glu Val Gln Val Val Lys Val 
                1205                1210                1215    


<210>   2303
<211>   1176
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2303
atgacacttc cagttagaaa atccctgcac gatgcagttt tacaggcttc gaaagcggat   60
acttgggaac aagctaccaa ggaatggaat gaagtttcct ttatttttaa cggtatcggc   120
cgtagcaatt gtgtctgtgg aaatgccatc aaatacgctt atgaactctt taacggtgtc   180
acaggccaac gcctctttcc aattggtagc gactgtgttc gtcattttca tcgattgtcc   240
cttgaccagc aattggaaga ggaagaaaaa ctgctcagaa aggttgaaaa tctaaccaga   300
aaagctcaga aaaaggaaaa aatcaaggtc aataaaagta actttgacga gcgacttcta   360
aaatggctct gggaaaaagg tgttttcaaa cccaatcgtg gcaatcaatt tgcgcctgag   420
agagactacc agcttttcct agaagtcttt cagggaggaa gttggaccaa ggcggaacca   480
aagaaaaagg ctcggatgga agaagtcctt gaaaagtgta tcaaaccctt tttacttggg   540
aaatcggatg accaactcta ccttgtcaag ctaggcaagg agaaaattga ctacgaacaa   600
gaactccgta tccaggcaga gaaagaacgc aagaagaggg ataaaatcgc caagcaatat   660
gcagacaatc tggttctagc catgggaccc gcagagcgtg cttatcaaga ttactttggc   720
tttacagaga ccctgactca agaagaacgc aagtgggaaa aaattctttt tggtaaaaat   780
agagcagaac gagctatcaa ggccaaacaa taccaaaaag agctggaaaa agaccaacga   840
attgccagtc aggatccaat tgaaagaaaa cagaagcaga cttggatcct caattcctat   900
tttcgtgagc ttcctgaaga aaaagctcga ttttctagac tcttattaga atatagaaaa   960
agtggtgaag tacccttttc aactgaatac ctgtcagatc atctcatcga ctttttctat   1020
aaaatgaaag cctttgaatt tgaaatcgca ccagaacaag tccgagattt tctaaaaaaa   1080
agcctgcagg aagaccatcg ctcatcagca caaggaagct ggatagaagg aattctcctc   1140
aactgcctca aaccattttt agaacgatta gtgata                             1176

<210>   2304
<211>   392
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903085 (0.E+01)

<400>   2304
Met Thr Leu Pro Val Arg Lys Ser Leu His Asp Ala Val Leu Gln Ala 
1               5                   10                  15      

Ser Lys Ala Asp Thr Trp Glu Gln Ala Thr Lys Glu Trp Asn Glu Val 
            20                  25                  30          

Ser Phe Ile Phe Asn Gly Ile Gly Arg Ser Asn Cys Val Cys Gly Asn 
        35                  40                  45              

Ala Ile Lys Tyr Ala Tyr Glu Leu Phe Asn Gly Val Thr Gly Gln Arg 
    50                  55                  60                  

Leu Phe Pro Ile Gly Ser Asp Cys Val Arg His Phe His Arg Leu Ser 
65                  70                  75                  80  

Leu Asp Gln Gln Leu Glu Glu Glu Glu Lys Leu Leu Arg Lys Val Glu 
                85                  90                  95      

Asn Leu Thr Arg Lys Ala Gln Lys Lys Glu Lys Ile Lys Val Asn Lys 
            100                 105                 110         

Ser Asn Phe Asp Glu Arg Leu Leu Lys Trp Leu Trp Glu Lys Gly Val 
        115                 120                 125             

Phe Lys Pro Asn Arg Gly Asn Gln Phe Ala Pro Glu Arg Asp Tyr Gln 
    130                 135                 140                 

Leu Phe Leu Glu Val Phe Gln Gly Gly Ser Trp Thr Lys Ala Glu Pro 
145                 150                 155                 160 

Lys Lys Lys Ala Arg Met Glu Glu Val Leu Glu Lys Cys Ile Lys Pro 
                165                 170                 175     

Phe Leu Leu Gly Lys Ser Asp Asp Gln Leu Tyr Leu Val Lys Leu Gly 
            180                 185                 190         

Lys Glu Lys Ile Asp Tyr Glu Gln Glu Leu Arg Ile Gln Ala Glu Lys 
        195                 200                 205             

Glu Arg Lys Lys Arg Asp Lys Ile Ala Lys Gln Tyr Ala Asp Asn Leu 
    210                 215                 220                 

Val Leu Ala Met Gly Pro Ala Glu Arg Ala Tyr Gln Asp Tyr Phe Gly 
225                 230                 235                 240 

Phe Thr Glu Thr Leu Thr Gln Glu Glu Arg Lys Trp Glu Lys Ile Leu 
                245                 250                 255     

Phe Gly Lys Asn Arg Ala Glu Arg Ala Ile Lys Ala Lys Gln Tyr Gln 
            260                 265                 270         

Lys Glu Leu Glu Lys Asp Gln Arg Ile Ala Ser Gln Asp Pro Ile Glu 
        275                 280                 285             

Arg Lys Gln Lys Gln Thr Trp Ile Leu Asn Ser Tyr Phe Arg Glu Leu 
    290                 295                 300                 

Pro Glu Glu Lys Ala Arg Phe Ser Arg Leu Leu Leu Glu Tyr Arg Lys 
305                 310                 315                 320 

Ser Gly Glu Val Pro Phe Ser Thr Glu Tyr Leu Ser Asp His Leu Ile 
                325                 330                 335     

Asp Phe Phe Tyr Lys Met Lys Ala Phe Glu Phe Glu Ile Ala Pro Glu 
            340                 345                 350         

Gln Val Arg Asp Phe Leu Lys Lys Ser Leu Gln Glu Asp His Arg Ser 
        355                 360                 365             

Ser Ala Gln Gly Ser Trp Ile Glu Gly Ile Leu Leu Asn Cys Leu Lys 
    370                 375                 380                 

Pro Phe Leu Glu Arg Leu Val Ile 
385                 390         

<210>   2305
<211>   6012
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2305
atggaaaagt attttggtga aaaacaagag cgtttttcat ttagaaaatt atcagtagga   60
cttgtatctg caacgatttc aagtttattt tttatgtctg tattagctag ttcatctgtg   120
gatgctcaag aaactgcggg agttcactat aaatatgtgg cagattcaga gctatcatca   180
gaagaaaaga agcagcttgt ctatgatatt ccgacatacg tggagaatga tgatgaaact   240
tattatcttg tttataagtt aaattctcaa aatcaactgg cggaattgcc aaatactgga   300
agcaagaatg agaggcaagc cctagttgct ggtgctagct tagctgctat gggaatttta   360
atttttgctg tttccaagaa aaaggttaag aataaaacgg tattacattt agtattggtt   420
gcagggatag gaaatggtgt cttagtttca gtccatgctt tagaaaatca tcttttgcta   480
aattacaata cggactatga attgacctct ggagaaaaat tacctcttcc taaagagatt   540
tcaggttaca cttatattgg atatatcaaa gagggaaaaa cgacttctga gtctgaagta   600
agtaatcaaa agagttcagt tgccactcct acaaaacaac aaaaggtgga ttataatgtt   660
acaccgaatt ttgtagacca tccatcaaca gtacaagcta ttcaggaaca aacacctgtt   720
tcttcaacta agccgacaga agttcaagta gttgaaaaac ctttctctac tgaattaatc   780
aatccaagaa aagaagagaa acaatcttca gattctcaag aacaattagc cgaacataag   840
aatctagaaa cgaagaaaga ggagaagatt tctccaaaag aaaagactgg ggtaaataca   900
ttaaatccac aggatgaagt tttatcaggt caattgaaca aacctgaact cttatatcgt   960
gaggaaacta tggagacaaa aatagatttt caagaagaaa ttcaagaaaa tcctgattta   1020
gctgaaggaa ctgtaagagt aaaacaagaa ggtaaattag gtaagaaagt tgaaatcgtc   1080
agaatattct ctgtaaacaa ggaagaagtt tcgcgagaaa ttgtttcaac ttcaacgact   1140
gcgcctagtc caagaatagt cgaaaaaggt actaaaaaaa ctcaagttat aaaggaacaa   1200
cctgagactg gtgtagaaca taaggacgta cagtctggag ctattgttga acccgcaatt   1260
cagcctgagt tgcccgaagc tgtagtaagt gacaaaggcg aaccagaagt tcaacctaca   1320
ttacccgaag cagttgtgac cgacaaaggt gagactgagg ttcaaccaga gtcgccagat   1380
actgtggtaa gtgataaagg tgaaccagag caggtagcac cgcttccaga atataagggt   1440
aatattgagc aagtaaaacc tgaaactccg gttgagaaga ccaaagaaca aggtccagaa   1500
aaaactgaag aagttccagt aaaaccaaca gaagaaacac cagtaaatcc aaatgaaggt   1560
actacagaag gaacctcaat tcaagaagca gaaaatccag ttcaacctgc agaagaatca   1620
acaacgaatt cagagaaagt atcaccagat acatctagca aaaatactgg ggaagtgtcc   1680
agtaatccta gtgattcgac aacctcagtt ggagaatcaa ataaaccaga acataatgac   1740
tctaaaaatg aaaattcaga aaaaactgta gaagaagttc cagtaaatcc aaatgaaggc   1800
acagtagaag gtacctcaaa tcaagaaaca gaaaaaccag ttcaacctgc agaagaaaca   1860
caaacaaact ctgggaaaat agctaacgaa aatactggag aagtatccaa taaacctagt   1920
gattcaaaac caccagttga agaatcaaat caaccagaaa aaaacggaac tgcaacaaaa   1980
ccagaaaatt caggtaatac aacatcagag aatggacaaa cagaaccaga accatcaaac   2040
ggaaattcaa ctgaggatgt ttcaaccgaa tcaaacacat ccaattcaaa tggaaacgaa   2100
gaaattaaac aagaaaatga actagaccct gataaaaagg tagaagaacc agagaaaaca   2160
cttgaattaa gaaatgtttc cgacctagag ttatacagtt tgtcaaatgg tacttataaa   2220
caacacattt cgttagagca agttccaagc aatccaaata gctactttgt taaagtgaaa   2280
tcttcttcat tcaaagatgt atacctacca gtagcatcaa tatcagagga aagaaaaaat   2340
gataaaatcc tttataaaat cacagcaaaa gtagagaagc ttcagcagga gatagaaagc   2400
agatataaag ataattttac cttctatcta gctaagaagg gaacagaaga aacaacaaac   2460
tttacttcct ttagtaatct ggtcaaagct ataaaccaaa atccctctgg aacctatcat   2520
ttagcggcca gcctgaatgc taacgaagtg gagcttggtc ctgatgaaag atcctatatc   2580
aaggacacct ttactggtcg tttaatcggt gaaaaagatg gcaagaatta tgctatctat   2640
aatttgaaaa aacctctgtt tgaaaacttg agtggtgcta cagtagaaaa actgagtcta   2700
aaaaatgttg ctatttcagg gaaagatgat atcggttcac tggcaaatga agctcagaat   2760
aacacaaaaa ttaagcaagt tcacgtcgat ggtgttctgg ctggtgaacg tggtatcggt   2820
ggtttgctgg ctaaggctga gcaatcaagc atcacagaga gcagtttcaa gggaagaatt   2880
atcaacactt atgaaacgac tgctgcctac aatatcggtg gtatggtcgg tcatttgaca   2940
ggtgacaagg ctttacttac taagtcaaaa gcgacagtag ccatttcatc taacacaaat   3000
acttcagatc agactgtggg tggacttgca ggcctagtag accgagatgc acagatccaa   3060
gatagctatg ctgaaggtga tatcaacaat gtcaagcact ttggtagagt cgctggagtg   3120
gcaggcaatt tgtgggatcg aacttctggt gatgttaggc atgctggaag tttgaccaat   3180
gttctcagcg atgttaatgt aaccaacgga aatgccatca ctggttacca ctataacgaa   3240
atgaaggtaa aggacacatt cagcagcaag gccaacagag tctacaatgt caccttggtc   3300
aaggatgagg tcgtcagcaa ggaatccttt gaagaaagag gaacaatgct agatgcttct   3360
caaattgcaa gcaaaaaagc agaaatcaat cctctcattt taccaacagt ggagccactt   3420
tcaacaagtg gcaaaaaaga cagtgatttt tctaaggtgg cctattatca agctaagcgc   3480
aacttgactt ataaaaacat tgaaaaattg ctacctttct acaacaaggc aaccatcgtc   3540
aaatacggaa acctggtcaa tgagaacagt cttttatatc aaaaagaact cttgtcagca   3600
gtcatgatga aggacaacca agtcatcaca gacattgttt ctaacaaaca gactgcaaac   3660
aaactcttgc ttcactacaa ggatgattta tctgagaagc tggatctcaa ataccagaat   3720
gatttcgcca aattagcaga atatagtctg ggcaatactg gacttctcta tacgccaaac   3780
caattcctgt atgaccaaac ctctatcatc aagcaagtct tacctgactt acaaaaggtt   3840
gactatcatt cagaagccat cagaaagacg ctgggtattt ctccaaacgt caagcaaact   3900
gagctctatc tagaagacca gttcgccaaa acaaaacaac aactggaaga cagtttgaaa   3960
aaactcttgt cagcggatgc tggactggct agtgctaacc ccgtcactga aggttatctt   4020
gtagataaaa tcaaacgcaa caaggaagcc ttgctacttg gcttgaccta tctggaacgg   4080
tggtataact ttagctatgg tcaggtgaat gtcaaagacc tagttctgta ccatttggac   4140
ttctttggta aggggaatgc ttcaccatta gatactctga ttgagttggg taaatctggc   4200
tttaacaatc ttctagctaa gaataatgtc gatacttatg gtatcagtct tgccagtcaa   4260
catggaacga cagatttgtt tagcacgctg gaacattacc gaaaagtctt tttaccaaat   4320
acaagcaata atgactggtt taaatcagag actaaggctt acattgtcga agaaaaatcc   4380
actatcgaag aggtgaaaac gaagcaaggg ttagctggca ccaagtattc tatcggtgtt   4440
tatgatcgta tcacgagtgc cacatggaaa taccgcaata tggtcttgcc tctcctgacc   4500
ttgccagaga gatccgtatt tgtcatctcg accatgtcta gtctaggatt tggagcttat   4560
gatcgctacc gcagtagtga ccataaagcg ggcaaggctc tcaatgattt tgttgaagaa   4620
aatgcgcgtg aaacagccaa acgtcagcga gatcactacg attattggta tcgtatttta   4680
gacgacaatg cacgtgaaaa actttataga aatattttgc tttacgatgc ttataaattt   4740
ggcgatgata ataccgtagg gaaagctaca gaagtggcag attttgataa tccaaatcct   4800
gcaatgcaac atttctttgg acctgttgga aataaagttg ggcataatca acacggtgct   4860
tatgctacag gtgatgcagt ttattatatg ggttatcgaa tgttggataa ggatggagct   4920
attacttata cgcatgagat gacacatgac tcagatcagg acatttatct tggaggatat   4980
ggtcgaagaa gtggcttggg accagagttc tttgctaaag gattattaca agcaccagac   5040
catccagatg atgcgaccat taccatcaac tccatcttga aacattcaaa atctgatagt   5100
acagaaagtc gacgattaca agtacttgat ccaactacaa gatttaataa tgcagatgat   5160
ttgaagcaat atgtccacaa catgtttgac gttgtttata tgttggaata tctcgaagga   5220
aattcaattc ttaaattgga tacgaatcaa aaacaacaac ttcttagaaa agttacaaat   5280
gagtaccatc ctgatcctga tggaaataag gtctatgcaa caaatgttgt cagaaatcta   5340
acagtagaag aagttgaaag actacgttca ttcaatgatt tgattgataa taatattctt   5400
tcgtctaggg aatatgcctc aggtaaatac gaaagaaatg gctacttcac tattaagtta   5460
tttgcaccga tttatgctgc attaagtaat gatataggaa caccaggtga cctgatggga   5520
cgtcgtatag cctatgaact actagctgct aaaggcttta aagatggtat ggtaccatat   5580
atctcaaacc aatacgaaga agaagccaaa caaaagggca agacaatcaa tctctacggt   5640
aaaacaagag gtttggttac agatgacttg gttttggaaa aggtatttaa taaccaatat   5700
catacttgga gtgagtttaa gaaagctatg tatcaagaac gacaagatca gtttgataga   5760
ttgaacaaag ttacttttaa tgatacaaca cagccttggc aaacatttgc caagaaaact   5820
acaagcagtg tagatgaatt acagaaatta atggacgttg ctgttcgtaa ggatgcagaa   5880
cacaattact accattggaa taactacaat ccagacatag atagtgaagt ccacaagctc   5940
aagagagcaa tctttaaagc ctatcttgac caaacaaatg attttagaag ttcaattttt   6000
gagaataaaa aa                                                       6012

<210>   2306
<211>   2004
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   immunoglobulin A1 protease (iga)
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15903086 (0.E+01)

<400>   2306
Met Glu Lys Tyr Phe Gly Glu Lys Gln Glu Arg Phe Ser Phe Arg Lys 
1               5                   10                  15      

Leu Ser Val Gly Leu Val Ser Ala Thr Ile Ser Ser Leu Phe Phe Met 
            20                  25                  30          

Ser Val Leu Ala Ser Ser Ser Val Asp Ala Gln Glu Thr Ala Gly Val 
        35                  40                  45              

His Tyr Lys Tyr Val Ala Asp Ser Glu Leu Ser Ser Glu Glu Lys Lys 
    50                  55                  60                  

Gln Leu Val Tyr Asp Ile Pro Thr Tyr Val Glu Asn Asp Asp Glu Thr 
65                  70                  75                  80  

Tyr Tyr Leu Val Tyr Lys Leu Asn Ser Gln Asn Gln Leu Ala Glu Leu 
                85                  90                  95      

Pro Asn Thr Gly Ser Lys Asn Glu Arg Gln Ala Leu Val Ala Gly Ala 
            100                 105                 110         

Ser Leu Ala Ala Met Gly Ile Leu Ile Phe Ala Val Ser Lys Lys Lys 
        115                 120                 125             

Val Lys Asn Lys Thr Val Leu His Leu Val Leu Val Ala Gly Ile Gly 
    130                 135                 140                 

Asn Gly Val Leu Val Ser Val His Ala Leu Glu Asn His Leu Leu Leu 
145                 150                 155                 160 

Asn Tyr Asn Thr Asp Tyr Glu Leu Thr Ser Gly Glu Lys Leu Pro Leu 
                165                 170                 175     

Pro Lys Glu Ile Ser Gly Tyr Thr Tyr Ile Gly Tyr Ile Lys Glu Gly 
            180                 185                 190         

Lys Thr Thr Ser Glu Ser Glu Val Ser Asn Gln Lys Ser Ser Val Ala 
        195                 200                 205             

Thr Pro Thr Lys Gln Gln Lys Val Asp Tyr Asn Val Thr Pro Asn Phe 
    210                 215                 220                 

Val Asp His Pro Ser Thr Val Gln Ala Ile Gln Glu Gln Thr Pro Val 
225                 230                 235                 240 

Ser Ser Thr Lys Pro Thr Glu Val Gln Val Val Glu Lys Pro Phe Ser 
                245                 250                 255     

Thr Glu Leu Ile Asn Pro Arg Lys Glu Glu Lys Gln Ser Ser Asp Ser 
            260                 265                 270         

Gln Glu Gln Leu Ala Glu His Lys Asn Leu Glu Thr Lys Lys Glu Glu 
        275                 280                 285             

Lys Ile Ser Pro Lys Glu Lys Thr Gly Val Asn Thr Leu Asn Pro Gln 
    290                 295                 300                 

Asp Glu Val Leu Ser Gly Gln Leu Asn Lys Pro Glu Leu Leu Tyr Arg 
305                 310                 315                 320 

Glu Glu Thr Met Glu Thr Lys Ile Asp Phe Gln Glu Glu Ile Gln Glu 
                325                 330                 335     

Asn Pro Asp Leu Ala Glu Gly Thr Val Arg Val Lys Gln Glu Gly Lys 
            340                 345                 350         

Leu Gly Lys Lys Val Glu Ile Val Arg Ile Phe Ser Val Asn Lys Glu 
        355                 360                 365             

Glu Val Ser Arg Glu Ile Val Ser Thr Ser Thr Thr Ala Pro Ser Pro 
    370                 375                 380                 

Arg Ile Val Glu Lys Gly Thr Lys Lys Thr Gln Val Ile Lys Glu Gln 
385                 390                 395                 400 

Pro Glu Thr Gly Val Glu His Lys Asp Val Gln Ser Gly Ala Ile Val 
                405                 410                 415     

Glu Pro Ala Ile Gln Pro Glu Leu Pro Glu Ala Val Val Ser Asp Lys 
            420                 425                 430         

Gly Glu Pro Glu Val Gln Pro Thr Leu Pro Glu Ala Val Val Thr Asp 
        435                 440                 445             

Lys Gly Glu Thr Glu Val Gln Pro Glu Ser Pro Asp Thr Val Val Ser 
    450                 455                 460                 

Asp Lys Gly Glu Pro Glu Gln Val Ala Pro Leu Pro Glu Tyr Lys Gly 
465                 470                 475                 480 

Asn Ile Glu Gln Val Lys Pro Glu Thr Pro Val Glu Lys Thr Lys Glu 
                485                 490                 495     

Gln Gly Pro Glu Lys Thr Glu Glu Val Pro Val Lys Pro Thr Glu Glu 
            500                 505                 510         

Thr Pro Val Asn Pro Asn Glu Gly Thr Thr Glu Gly Thr Ser Ile Gln 
        515                 520                 525             

Glu Ala Glu Asn Pro Val Gln Pro Ala Glu Glu Ser Thr Thr Asn Ser 
    530                 535                 540                 

Glu Lys Val Ser Pro Asp Thr Ser Ser Lys Asn Thr Gly Glu Val Ser 
545                 550                 555                 560 

Ser Asn Pro Ser Asp Ser Thr Thr Ser Val Gly Glu Ser Asn Lys Pro 
                565                 570                 575     

Glu His Asn Asp Ser Lys Asn Glu Asn Ser Glu Lys Thr Val Glu Glu 
            580                 585                 590         

Val Pro Val Asn Pro Asn Glu Gly Thr Val Glu Gly Thr Ser Asn Gln 
        595                 600                 605             

Glu Thr Glu Lys Pro Val Gln Pro Ala Glu Glu Thr Gln Thr Asn Ser 
    610                 615                 620                 

Gly Lys Ile Ala Asn Glu Asn Thr Gly Glu Val Ser Asn Lys Pro Ser 
625                 630                 635                 640 

Asp Ser Lys Pro Pro Val Glu Glu Ser Asn Gln Pro Glu Lys Asn Gly 
                645                 650                 655     

Thr Ala Thr Lys Pro Glu Asn Ser Gly Asn Thr Thr Ser Glu Asn Gly 
            660                 665                 670         

Gln Thr Glu Pro Glu Pro Ser Asn Gly Asn Ser Thr Glu Asp Val Ser 
        675                 680                 685             

Thr Glu Ser Asn Thr Ser Asn Ser Asn Gly Asn Glu Glu Ile Lys Gln 
    690                 695                 700                 

Glu Asn Glu Leu Asp Pro Asp Lys Lys Val Glu Glu Pro Glu Lys Thr 
705                 710                 715                 720 

Leu Glu Leu Arg Asn Val Ser Asp Leu Glu Leu Tyr Ser Leu Ser Asn 
                725                 730                 735     

Gly Thr Tyr Lys Gln His Ile Ser Leu Glu Gln Val Pro Ser Asn Pro 
            740                 745                 750         

Asn Ser Tyr Phe Val Lys Val Lys Ser Ser Ser Phe Lys Asp Val Tyr 
        755                 760                 765             

Leu Pro Val Ala Ser Ile Ser Glu Glu Arg Lys Asn Asp Lys Ile Leu 
    770                 775                 780                 

Tyr Lys Ile Thr Ala Lys Val Glu Lys Leu Gln Gln Glu Ile Glu Ser 
785                 790                 795                 800 

Arg Tyr Lys Asp Asn Phe Thr Phe Tyr Leu Ala Lys Lys Gly Thr Glu 
                805                 810                 815     

Glu Thr Thr Asn Phe Thr Ser Phe Ser Asn Leu Val Lys Ala Ile Asn 
            820                 825                 830         

Gln Asn Pro Ser Gly Thr Tyr His Leu Ala Ala Ser Leu Asn Ala Asn 
        835                 840                 845             

Glu Val Glu Leu Gly Pro Asp Glu Arg Ser Tyr Ile Lys Asp Thr Phe 
    850                 855                 860                 

Thr Gly Arg Leu Ile Gly Glu Lys Asp Gly Lys Asn Tyr Ala Ile Tyr 
865                 870                 875                 880 

Asn Leu Lys Lys Pro Leu Phe Glu Asn Leu Ser Gly Ala Thr Val Glu 
                885                 890                 895     

Lys Leu Ser Leu Lys Asn Val Ala Ile Ser Gly Lys Asp Asp Ile Gly 
            900                 905                 910         

Ser Leu Ala Asn Glu Ala Gln Asn Asn Thr Lys Ile Lys Gln Val His 
        915                 920                 925             

Val Asp Gly Val Leu Ala Gly Glu Arg Gly Ile Gly Gly Leu Leu Ala 
    930                 935                 940                 

Lys Ala Glu Gln Ser Ser Ile Thr Glu Ser Ser Phe Lys Gly Arg Ile 
945                 950                 955                 960 

Ile Asn Thr Tyr Glu Thr Thr Ala Ala Tyr Asn Ile Gly Gly Met Val 
                965                 970                 975     

Gly His Leu Thr Gly Asp Lys Ala Leu Leu Thr Lys Ser Lys Ala Thr 
            980                 985                 990         

Val Ala Ile Ser Ser Asn Thr Asn Thr Ser Asp Gln Thr Val Gly Gly 
        995                 1000                1005            

Leu Ala Gly Leu Val Asp Arg Asp Ala Gln Ile Gln Asp Ser Tyr Ala 
    1010                1015                1020                

Glu Gly Asp Ile Asn Asn Val Lys His Phe Gly Arg Val Ala Gly Val 
1025                1030                1035                1040

Ala Gly Asn Leu Trp Asp Arg Thr Ser Gly Asp Val Arg His Ala Gly 
                1045                1050                1055    

Ser Leu Thr Asn Val Leu Ser Asp Val Asn Val Thr Asn Gly Asn Ala 
            1060                1065                1070        

Ile Thr Gly Tyr His Tyr Asn Glu Met Lys Val Lys Asp Thr Phe Ser 
        1075                1080                1085            

Ser Lys Ala Asn Arg Val Tyr Asn Val Thr Leu Val Lys Asp Glu Val 
    1090                1095                1100                

Val Ser Lys Glu Ser Phe Glu Glu Arg Gly Thr Met Leu Asp Ala Ser 
1105                1110                1115                1120

Gln Ile Ala Ser Lys Lys Ala Glu Ile Asn Pro Leu Ile Leu Pro Thr 
                1125                1130                1135    

Val Glu Pro Leu Ser Thr Ser Gly Lys Lys Asp Ser Asp Phe Ser Lys 
            1140                1145                1150        

Val Ala Tyr Tyr Gln Ala Lys Arg Asn Leu Thr Tyr Lys Asn Ile Glu 
        1155                1160                1165            

Lys Leu Leu Pro Phe Tyr Asn Lys Ala Thr Ile Val Lys Tyr Gly Asn 
    1170                1175                1180                

Leu Val Asn Glu Asn Ser Leu Leu Tyr Gln Lys Glu Leu Leu Ser Ala 
1185                1190                1195                1200

Val Met Met Lys Asp Asn Gln Val Ile Thr Asp Ile Val Ser Asn Lys 
                1205                1210                1215    

Gln Thr Ala Asn Lys Leu Leu Leu His Tyr Lys Asp Asp Leu Ser Glu 
            1220                1225                1230        

Lys Leu Asp Leu Lys Tyr Gln Asn Asp Phe Ala Lys Leu Ala Glu Tyr 
        1235                1240                1245            

Ser Leu Gly Asn Thr Gly Leu Leu Tyr Thr Pro Asn Gln Phe Leu Tyr 
    1250                1255                1260                

Asp Gln Thr Ser Ile Ile Lys Gln Val Leu Pro Asp Leu Gln Lys Val 
1265                1270                1275                1280

Asp Tyr His Ser Glu Ala Ile Arg Lys Thr Leu Gly Ile Ser Pro Asn 
                1285                1290                1295    

Val Lys Gln Thr Glu Leu Tyr Leu Glu Asp Gln Phe Ala Lys Thr Lys 
            1300                1305                1310        

Gln Gln Leu Glu Asp Ser Leu Lys Lys Leu Leu Ser Ala Asp Ala Gly 
        1315                1320                1325            

Leu Ala Ser Ala Asn Pro Val Thr Glu Gly Tyr Leu Val Asp Lys Ile 
    1330                1335                1340                

Lys Arg Asn Lys Glu Ala Leu Leu Leu Gly Leu Thr Tyr Leu Glu Arg 
1345                1350                1355                1360

Trp Tyr Asn Phe Ser Tyr Gly Gln Val Asn Val Lys Asp Leu Val Leu 
                1365                1370                1375    

Tyr His Leu Asp Phe Phe Gly Lys Gly Asn Ala Ser Pro Leu Asp Thr 
            1380                1385                1390        

Leu Ile Glu Leu Gly Lys Ser Gly Phe Asn Asn Leu Leu Ala Lys Asn 
        1395                1400                1405            

Asn Val Asp Thr Tyr Gly Ile Ser Leu Ala Ser Gln His Gly Thr Thr 
    1410                1415                1420                

Asp Leu Phe Ser Thr Leu Glu His Tyr Arg Lys Val Phe Leu Pro Asn 
1425                1430                1435                1440

Thr Ser Asn Asn Asp Trp Phe Lys Ser Glu Thr Lys Ala Tyr Ile Val 
                1445                1450                1455    

Glu Glu Lys Ser Thr Ile Glu Glu Val Lys Thr Lys Gln Gly Leu Ala 
            1460                1465                1470        

Gly Thr Lys Tyr Ser Ile Gly Val Tyr Asp Arg Ile Thr Ser Ala Thr 
        1475                1480                1485            

Trp Lys Tyr Arg Asn Met Val Leu Pro Leu Leu Thr Leu Pro Glu Arg 
    1490                1495                1500                

Ser Val Phe Val Ile Ser Thr Met Ser Ser Leu Gly Phe Gly Ala Tyr 
1505                1510                1515                1520

Asp Arg Tyr Arg Ser Ser Asp His Lys Ala Gly Lys Ala Leu Asn Asp 
                1525                1530                1535    

Phe Val Glu Glu Asn Ala Arg Glu Thr Ala Lys Arg Gln Arg Asp His 
            1540                1545                1550        

Tyr Asp Tyr Trp Tyr Arg Ile Leu Asp Asp Asn Ala Arg Glu Lys Leu 
        1555                1560                1565            

Tyr Arg Asn Ile Leu Leu Tyr Asp Ala Tyr Lys Phe Gly Asp Asp Asn 
    1570                1575                1580                

Thr Val Gly Lys Ala Thr Glu Val Ala Asp Phe Asp Asn Pro Asn Pro 
1585                1590                1595                1600

Ala Met Gln His Phe Phe Gly Pro Val Gly Asn Lys Val Gly His Asn 
                1605                1610                1615    

Gln His Gly Ala Tyr Ala Thr Gly Asp Ala Val Tyr Tyr Met Gly Tyr 
            1620                1625                1630        

Arg Met Leu Asp Lys Asp Gly Ala Ile Thr Tyr Thr His Glu Met Thr 
        1635                1640                1645            

His Asp Ser Asp Gln Asp Ile Tyr Leu Gly Gly Tyr Gly Arg Arg Ser 
    1650                1655                1660                

Gly Leu Gly Pro Glu Phe Phe Ala Lys Gly Leu Leu Gln Ala Pro Asp 
1665                1670                1675                1680

His Pro Asp Asp Ala Thr Ile Thr Ile Asn Ser Ile Leu Lys His Ser 
                1685                1690                1695    

Lys Ser Asp Ser Thr Glu Ser Arg Arg Leu Gln Val Leu Asp Pro Thr 
            1700                1705                1710        

Thr Arg Phe Asn Asn Ala Asp Asp Leu Lys Gln Tyr Val His Asn Met 
        1715                1720                1725            

Phe Asp Val Val Tyr Met Leu Glu Tyr Leu Glu Gly Asn Ser Ile Leu 
    1730                1735                1740                

Lys Leu Asp Thr Asn Gln Lys Gln Gln Leu Leu Arg Lys Val Thr Asn 
1745                1750                1755                1760

Glu Tyr His Pro Asp Pro Asp Gly Asn Lys Val Tyr Ala Thr Asn Val 
                1765                1770                1775    

Val Arg Asn Leu Thr Val Glu Glu Val Glu Arg Leu Arg Ser Phe Asn 
            1780                1785                1790        

Asp Leu Ile Asp Asn Asn Ile Leu Ser Ser Arg Glu Tyr Ala Ser Gly 
        1795                1800                1805            

Lys Tyr Glu Arg Asn Gly Tyr Phe Thr Ile Lys Leu Phe Ala Pro Ile 
    1810                1815                1820                

Tyr Ala Ala Leu Ser Asn Asp Ile Gly Thr Pro Gly Asp Leu Met Gly 
1825                1830                1835                1840

Arg Arg Ile Ala Tyr Glu Leu Leu Ala Ala Lys Gly Phe Lys Asp Gly 
                1845                1850                1855    

Met Val Pro Tyr Ile Ser Asn Gln Tyr Glu Glu Glu Ala Lys Gln Lys 
            1860                1865                1870        

Gly Lys Thr Ile Asn Leu Tyr Gly Lys Thr Arg Gly Leu Val Thr Asp 
        1875                1880                1885            

Asp Leu Val Leu Glu Lys Val Phe Asn Asn Gln Tyr His Thr Trp Ser 
    1890                1895                1900                

Glu Phe Lys Lys Ala Met Tyr Gln Glu Arg Gln Asp Gln Phe Asp Arg 
1905                1910                1915                1920

Leu Asn Lys Val Thr Phe Asn Asp Thr Thr Gln Pro Trp Gln Thr Phe 
                1925                1930                1935    

Ala Lys Lys Thr Thr Ser Ser Val Asp Glu Leu Gln Lys Leu Met Asp 
            1940                1945                1950        

Val Ala Val Arg Lys Asp Ala Glu His Asn Tyr Tyr His Trp Asn Asn 
        1955                1960                1965            

Tyr Asn Pro Asp Ile Asp Ser Glu Val His Lys Leu Lys Arg Ala Ile 
    1970                1975                1980                

Phe Lys Ala Tyr Leu Asp Gln Thr Asn Asp Phe Arg Ser Ser Ile Phe 
1985                1990                1995                2000

Glu Asn Lys Lys 
                

<210>   2307
<211>   849
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2307
atggctacta ttcaatggtt tcctggtcac atgtctaaag ctcgtcgaca ggtgcaggag   60
aatttaaaat ttgttgattt tgtgacgatt ttagtagatg cacgcttgcc tctatctagt   120
caaaatccta tgttgaccaa gattgttggt gataaaccaa aactcttgat tttaaacaag   180
gccgacttgg ctgatccagc aatgaccaag gaatggcgtc agtattttga atcacaagga   240
atccagacgc tagctatcaa ctccaaagag caagtgactg taaaagttgt aacagatgcg   300
gccaagaagc tcatggctga taagattgct cgccagaaag aacgtgggat tcagattgaa   360
accttgcgta ctatgattat cgggattcca aacgctggta aatcaactct gatgaaccgt   420
ttggctggta aaaagattgc tgttgttgga aacaagccag gggtcacaaa aggtcaacaa   480
tggcttaaaa ccaataaaga cctggaaatc ttggatacac cggggattct ctggcctaag   540
tttgaggatg aaactgttgc acttaagttg gcattgactg gagctatcaa agaccagttg   600
cttcctatgg atgaggttac catttttggt atcaattatt tcaaagaaca ttatccagaa   660
aagctggctg aacgcttcaa acaaatgaaa attgaagaag aagcgcctgt gattattatg   720
gatatgaccc gcgccctcgg tttccgtgat gactatgacc gtttttacag tctcttcgtg   780
aaggaagtcc gtgatggcaa actcggtaac tataccttag atacattgga agacctcgat   840
ggcaacgat                                                           849

<210>   2308
<211>   283
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903087 (e-161)

<400>   2308
Met Ala Thr Ile Gln Trp Phe Pro Gly His Met Ser Lys Ala Arg Arg 
1               5                   10                  15      

Gln Val Gln Glu Asn Leu Lys Phe Val Asp Phe Val Thr Ile Leu Val 
            20                  25                  30          

Asp Ala Arg Leu Pro Leu Ser Ser Gln Asn Pro Met Leu Thr Lys Ile 
        35                  40                  45              

Val Gly Asp Lys Pro Lys Leu Leu Ile Leu Asn Lys Ala Asp Leu Ala 
    50                  55                  60                  

Asp Pro Ala Met Thr Lys Glu Trp Arg Gln Tyr Phe Glu Ser Gln Gly 
65                  70                  75                  80  

Ile Gln Thr Leu Ala Ile Asn Ser Lys Glu Gln Val Thr Val Lys Val 
                85                  90                  95      

Val Thr Asp Ala Ala Lys Lys Leu Met Ala Asp Lys Ile Ala Arg Gln 
            100                 105                 110         

Lys Glu Arg Gly Ile Gln Ile Glu Thr Leu Arg Thr Met Ile Ile Gly 
        115                 120                 125             

Ile Pro Asn Ala Gly Lys Ser Thr Leu Met Asn Arg Leu Ala Gly Lys 
    130                 135                 140                 

Lys Ile Ala Val Val Gly Asn Lys Pro Gly Val Thr Lys Gly Gln Gln 
145                 150                 155                 160 

Trp Leu Lys Thr Asn Lys Asp Leu Glu Ile Leu Asp Thr Pro Gly Ile 
                165                 170                 175     

Leu Trp Pro Lys Phe Glu Asp Glu Thr Val Ala Leu Lys Leu Ala Leu 
            180                 185                 190         

Thr Gly Ala Ile Lys Asp Gln Leu Leu Pro Met Asp Glu Val Thr Ile 
        195                 200                 205             

Phe Gly Ile Asn Tyr Phe Lys Glu His Tyr Pro Glu Lys Leu Ala Glu 
    210                 215                 220                 

Arg Phe Lys Gln Met Lys Ile Glu Glu Glu Ala Pro Val Ile Ile Met 
225                 230                 235                 240 

Asp Met Thr Arg Ala Leu Gly Phe Arg Asp Asp Tyr Asp Arg Phe Tyr 
                245                 250                 255     

Ser Leu Phe Val Lys Glu Val Arg Asp Gly Lys Leu Gly Asn Tyr Thr 
            260                 265                 270         

Leu Asp Thr Leu Glu Asp Leu Asp Gly Asn Asp 
        275                 280             

<210>   2309
<211>   777
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2309
atggcaacga ttaaagaaat caaagaattc cttgtgacag tcaaggagtt agaaagccct   60
atttttttag agcttgaaaa ggataatcgc tcaggagttc aaaaggaaat cagcaagcgt   120
aaaagagcca ttcaagctga attagatgaa aatttgcgct tggaatccat gctttcttat   180
gaaaaagaac tttataagca aggattgacc ttaattgcag gtattgatga ggttggtcgt   240
ggtcctcttg ctggtcctgt agtcgctgcg gccgttattt tatctaaaaa ttgtaagatt   300
aaaggtctca acgacagcaa gaaaattcct aaaaagaaac atctggagat tttccaagcc   360
gttcaagacc aagccttgtc gattggaatt ggtatcatag ataatcaggt catcgaccaa   420
gtcaacatct atgaagcaac caaactagcc atgcaagaag caatctccca gctcagccct   480
caaccagagc accttttgat tgatgccatg aaactggact tgcccatttc acaaacctcc   540
attatcaaag gagatgccaa ctccctctct atcgcagcag catctatagt agccaaggta   600
acacgtgatg aattgctgaa agaatacgat cagcagttcc ctggctatga tttcgctact   660
aatgcaggat atggcacagc taaacatctg gaaggcctca caaaactagg agttacccca   720
attcaccgaa ccagctttga acccgttaaa tcactggttt taggtaaaaa agaaagt      777

<210>   2310
<211>   259
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribonuclease HII (rnhB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903088 (e-140)

<400>   2310
Met Ala Thr Ile Lys Glu Ile Lys Glu Phe Leu Val Thr Val Lys Glu 
1               5                   10                  15      

Leu Glu Ser Pro Ile Phe Leu Glu Leu Glu Lys Asp Asn Arg Ser Gly 
            20                  25                  30          

Val Gln Lys Glu Ile Ser Lys Arg Lys Arg Ala Ile Gln Ala Glu Leu 
        35                  40                  45              

Asp Glu Asn Leu Arg Leu Glu Ser Met Leu Ser Tyr Glu Lys Glu Leu 
    50                  55                  60                  

Tyr Lys Gln Gly Leu Thr Leu Ile Ala Gly Ile Asp Glu Val Gly Arg 
65                  70                  75                  80  

Gly Pro Leu Ala Gly Pro Val Val Ala Ala Ala Val Ile Leu Ser Lys 
                85                  90                  95      

Asn Cys Lys Ile Lys Gly Leu Asn Asp Ser Lys Lys Ile Pro Lys Lys 
            100                 105                 110         

Lys His Leu Glu Ile Phe Gln Ala Val Gln Asp Gln Ala Leu Ser Ile 
        115                 120                 125             

Gly Ile Gly Ile Ile Asp Asn Gln Val Ile Asp Gln Val Asn Ile Tyr 
    130                 135                 140                 

Glu Ala Thr Lys Leu Ala Met Gln Glu Ala Ile Ser Gln Leu Ser Pro 
145                 150                 155                 160 

Gln Pro Glu His Leu Leu Ile Asp Ala Met Lys Leu Asp Leu Pro Ile 
                165                 170                 175     

Ser Gln Thr Ser Ile Ile Lys Gly Asp Ala Asn Ser Leu Ser Ile Ala 
            180                 185                 190         

Ala Ala Ser Ile Val Ala Lys Val Thr Arg Asp Glu Leu Leu Lys Glu 
        195                 200                 205             

Tyr Asp Gln Gln Phe Pro Gly Tyr Asp Phe Ala Thr Asn Ala Gly Tyr 
    210                 215                 220                 

Gly Thr Ala Lys His Leu Glu Gly Leu Thr Lys Leu Gly Val Thr Pro 
225                 230                 235                 240 

Ile His Arg Thr Ser Phe Glu Pro Val Lys Ser Leu Val Leu Gly Lys 
                245                 250                 255     

Lys Glu Ser 
            

<210>   2311
<211>   1548
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2311
atggaggaac agtcggaaat agtccgttct aagaaagaat tcgcctttgc atccagcact   60
atactatccc aagttggtcg aggaatcatt gtcggcctca tcgttggaat tatcgtcgga   120
tcctttcgtt tcttaattga aaagggcttc cacctgatac aaggagttta tcaagatcaa   180
gggtacttag tgcgcaatct ttttgtactg gttttgtttt atatactcat ctgttggctc   240
agtgccaaac taacacggtc agaaaaagat attaaaggct caggaattcc tcaagtcgaa   300
gccgaactga aaggcctcat gtccctcaac tggtggggca ttctttggaa aaaatatgtg   360
ctaggtattc ttgctattgc cagtggactc atgctgggtc gagagggacc cagcattcaa   420
cttggagcag ttggtggtaa aggaattgcc aagtggctca aatccagtcc agtagaggaa   480
cgttccttga ttgccagtgg agctgcagca ggtttagccg cagcctttaa tgctcctatt   540
gcagcacttc tctttgttgt agaagaagtc tatcaccatt tttcgcgctt tttctgggtc   600
tcaactctag cagccagcat cgtagcaaac tttgtgtctc tactcatgtt cggtttgaca   660
ccagtattgg atatgccaga taacattcct cccatgaccc tagatcagta ttggatatat   720
ctcgtcatgg gaattttcct tggattttca ggttttctct atgagaaagc tgtattaaac   780
gttggaagag tttatgactt gattggtcaa aaaatccatt tggatagggc ttattatccc   840
atcttggctt ttatccttat cataccagtc ggaatcttct tacctcaaat cattggtggc   900
ggaaatcagc ttgtcctttc tttaactgaa caaaatttta gtttccaagt tttattagct   960
tactttttaa tccgctttat ttggagtatg attagctatg gaagtggact gccaggagga   1020
attttcctcc ccattttagc tcttggttct ttgcttggtg ccttagttgg tgttatctgt   1080
gtcaatcttg gacttgtcag tcaagagcaa ttccctatat ttgtcattct aggaatgagt   1140
ggctattttg gagccatatc aaaagctccc ttaaccgcta tgatcctcgt aactgagatg   1200
gtaggagata ttcgcaacct tatgccactt ggtcttgtca ctcttgtttc ttatattatc   1260
atggatttgc tcaaaggtac gccagtctat gaagccatgc tggaaaaaat gcttccagaa   1320
gaagtatcta gcgaaggaga agttacactt atcgaaatac cagtttctga taaaattgct   1380
gggaaacaag ttcatgaact caacttacca cacaacgtcc tcatcacaac tcaagtccat   1440
aatggcaaga gccaaacagt taacggctca accagaatgt atctgggtga tatgattcac   1500
ctggttattc caaaaagtga aattggaaaa gtcaaagatt tgttgttg                1548

<210>   2312
<211>   516
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   voltage-gated chloride channel family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903089 (0.E+01)

<400>   2312
Met Glu Glu Gln Ser Glu Ile Val Arg Ser Lys Lys Glu Phe Ala Phe 
1               5                   10                  15      

Ala Ser Ser Thr Ile Leu Ser Gln Val Gly Arg Gly Ile Ile Val Gly 
            20                  25                  30          

Leu Ile Val Gly Ile Ile Val Gly Ser Phe Arg Phe Leu Ile Glu Lys 
        35                  40                  45              

Gly Phe His Leu Ile Gln Gly Val Tyr Gln Asp Gln Gly Tyr Leu Val 
    50                  55                  60                  

Arg Asn Leu Phe Val Leu Val Leu Phe Tyr Ile Leu Ile Cys Trp Leu 
65                  70                  75                  80  

Ser Ala Lys Leu Thr Arg Ser Glu Lys Asp Ile Lys Gly Ser Gly Ile 
                85                  90                  95      

Pro Gln Val Glu Ala Glu Leu Lys Gly Leu Met Ser Leu Asn Trp Trp 
            100                 105                 110         

Gly Ile Leu Trp Lys Lys Tyr Val Leu Gly Ile Leu Ala Ile Ala Ser 
        115                 120                 125             

Gly Leu Met Leu Gly Arg Glu Gly Pro Ser Ile Gln Leu Gly Ala Val 
    130                 135                 140                 

Gly Gly Lys Gly Ile Ala Lys Trp Leu Lys Ser Ser Pro Val Glu Glu 
145                 150                 155                 160 

Arg Ser Leu Ile Ala Ser Gly Ala Ala Ala Gly Leu Ala Ala Ala Phe 
                165                 170                 175     

Asn Ala Pro Ile Ala Ala Leu Leu Phe Val Val Glu Glu Val Tyr His 
            180                 185                 190         

His Phe Ser Arg Phe Phe Trp Val Ser Thr Leu Ala Ala Ser Ile Val 
        195                 200                 205             

Ala Asn Phe Val Ser Leu Leu Met Phe Gly Leu Thr Pro Val Leu Asp 
    210                 215                 220                 

Met Pro Asp Asn Ile Pro Pro Met Thr Leu Asp Gln Tyr Trp Ile Tyr 
225                 230                 235                 240 

Leu Val Met Gly Ile Phe Leu Gly Phe Ser Gly Phe Leu Tyr Glu Lys 
                245                 250                 255     

Ala Val Leu Asn Val Gly Arg Val Tyr Asp Leu Ile Gly Gln Lys Ile 
            260                 265                 270         

His Leu Asp Arg Ala Tyr Tyr Pro Ile Leu Ala Phe Ile Leu Ile Ile 
        275                 280                 285             

Pro Val Gly Ile Phe Leu Pro Gln Ile Ile Gly Gly Gly Asn Gln Leu 
    290                 295                 300                 

Val Leu Ser Leu Thr Glu Gln Asn Phe Ser Phe Gln Val Leu Leu Ala 
305                 310                 315                 320 

Tyr Phe Leu Ile Arg Phe Ile Trp Ser Met Ile Ser Tyr Gly Ser Gly 
                325                 330                 335     

Leu Pro Gly Gly Ile Phe Leu Pro Ile Leu Ala Leu Gly Ser Leu Leu 
            340                 345                 350         

Gly Ala Leu Val Gly Val Ile Cys Val Asn Leu Gly Leu Val Ser Gln 
        355                 360                 365             

Glu Gln Phe Pro Ile Phe Val Ile Leu Gly Met Ser Gly Tyr Phe Gly 
    370                 375                 380                 

Ala Ile Ser Lys Ala Pro Leu Thr Ala Met Ile Leu Val Thr Glu Met 
385                 390                 395                 400 

Val Gly Asp Ile Arg Asn Leu Met Pro Leu Gly Leu Val Thr Leu Val 
                405                 410                 415     

Ser Tyr Ile Ile Met Asp Leu Leu Lys Gly Thr Pro Val Tyr Glu Ala 
            420                 425                 430         

Met Leu Glu Lys Met Leu Pro Glu Glu Val Ser Ser Glu Gly Glu Val 
        435                 440                 445             

Thr Leu Ile Glu Ile Pro Val Ser Asp Lys Ile Ala Gly Lys Gln Val 
    450                 455                 460                 

His Glu Leu Asn Leu Pro His Asn Val Leu Ile Thr Thr Gln Val His 
465                 470                 475                 480 

Asn Gly Lys Ser Gln Thr Val Asn Gly Ser Thr Arg Met Tyr Leu Gly 
                485                 490                 495     

Asp Met Ile His Leu Val Ile Pro Lys Ser Glu Ile Gly Lys Val Lys 
            500                 505                 510         

Asp Leu Leu Leu 
        515     

<210>   2313
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2313
ttgctagaaa ttgatttgat tgtcctgatt gttttatcct atttctattt catttctcta   60
tataattgct attgttttct ttttcatgat tttaatctta ctgtacagat t            111

<210>   2314
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   2314
Met Leu Glu Ile Asp Leu Ile Val Leu Ile Val Leu Ser Tyr Phe Tyr 
1               5                   10                  15      

Phe Ile Ser Leu Tyr Asn Cys Tyr Cys Phe Leu Phe His Asp Phe Asn 
            20                  25                  30          

Leu Thr Val Gln Ile 
        35          

<210>   2315
<211>   1068
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2315
atgaaacgtg agattttact ggaacgaatc gacaaactaa aacaactcat gccctggtat   60
gttctggaat actaccaatc taagctggct gtgccctaca gttttacaac cctgtacgaa   120
taccttaagg aatatgaccg atttttcagc tgggttttgg agtctggtat ttcaaacgct   180
gataaaatat ccgatattcc tttatcagtt ttggaaaata tgtctaagaa agacatggaa   240
tcctttatcc tttatctacg tgaacgtccc ttgctgaatg ctaatacaac aaaacaaggt   300
gtttcacaga caactatcaa tcgaacctta tcagcacttt ctagtcttta caagtatcta   360
accgaggagg ttgaaaacga tcagggggaa ccttatttct atcgtaatgt aatgaaaaaa   420
gtttccacca agaaaaagaa agaaaccctt gctgccagag ctgaaaatat caagcaaaaa   480
ctctttctag gtgatgaaac agaaggtttt ctaacttata tcgatcaaga gcacccacaa   540
cagctttcaa atcgagctct ctcatcattc aacaaaaata aagaacgaga tttagccatt   600
attgcccttc tcttggcatc tggtgttcgc ttatctgaag ctgttaatct agatctaaga   660
gatctcaatc taaaaatgat ggttattgat gttactcgaa aaggttgcaa acgtgactca   720
gtcaatgtcg ctgcttttgc taaaccttat ttagagaatt atctggccat tcggaatcaa   780
cgctataaaa cggaaaaaac agatacagcc ctttttttaa ctctctacag aggtgttcct   840
aatcgtatcg atgcttctag cgttgagaaa atggttgcta aatactcaga ggattttaaa   900
gtgcgtgtaa caccccataa actgcgccat acactagcaa ctaggctcta tgatgcgact   960
aaatcacaag ttttagtcag tcaccaacta ggacatgcta gcacacaagt cactgacctc   1020
tatacccata ttgttagtga tgaacaaaag aatgctctgg atagttta                1068

<210>   2316
<211>   356
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   integrase/recombinase, phage integrase family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903090 (0.E+01)

<400>   2316
Met Lys Arg Glu Ile Leu Leu Glu Arg Ile Asp Lys Leu Lys Gln Leu 
1               5                   10                  15      

Met Pro Trp Tyr Val Leu Glu Tyr Tyr Gln Ser Lys Leu Ala Val Pro 
            20                  25                  30          

Tyr Ser Phe Thr Thr Leu Tyr Glu Tyr Leu Lys Glu Tyr Asp Arg Phe 
        35                  40                  45              

Phe Ser Trp Val Leu Glu Ser Gly Ile Ser Asn Ala Asp Lys Ile Ser 
    50                  55                  60                  

Asp Ile Pro Leu Ser Val Leu Glu Asn Met Ser Lys Lys Asp Met Glu 
65                  70                  75                  80  

Ser Phe Ile Leu Tyr Leu Arg Glu Arg Pro Leu Leu Asn Ala Asn Thr 
                85                  90                  95      

Thr Lys Gln Gly Val Ser Gln Thr Thr Ile Asn Arg Thr Leu Ser Ala 
            100                 105                 110         

Leu Ser Ser Leu Tyr Lys Tyr Leu Thr Glu Glu Val Glu Asn Asp Gln 
        115                 120                 125             

Gly Glu Pro Tyr Phe Tyr Arg Asn Val Met Lys Lys Val Ser Thr Lys 
    130                 135                 140                 

Lys Lys Lys Glu Thr Leu Ala Ala Arg Ala Glu Asn Ile Lys Gln Lys 
145                 150                 155                 160 

Leu Phe Leu Gly Asp Glu Thr Glu Gly Phe Leu Thr Tyr Ile Asp Gln 
                165                 170                 175     

Glu His Pro Gln Gln Leu Ser Asn Arg Ala Leu Ser Ser Phe Asn Lys 
            180                 185                 190         

Asn Lys Glu Arg Asp Leu Ala Ile Ile Ala Leu Leu Leu Ala Ser Gly 
        195                 200                 205             

Val Arg Leu Ser Glu Ala Val Asn Leu Asp Leu Arg Asp Leu Asn Leu 
    210                 215                 220                 

Lys Met Met Val Ile Asp Val Thr Arg Lys Gly Cys Lys Arg Asp Ser 
225                 230                 235                 240 

Val Asn Val Ala Ala Phe Ala Lys Pro Tyr Leu Glu Asn Tyr Leu Ala 
                245                 250                 255     

Ile Arg Asn Gln Arg Tyr Lys Thr Glu Lys Thr Asp Thr Ala Leu Phe 
            260                 265                 270         

Leu Thr Leu Tyr Arg Gly Val Pro Asn Arg Ile Asp Ala Ser Ser Val 
        275                 280                 285             

Glu Lys Met Val Ala Lys Tyr Ser Glu Asp Phe Lys Val Arg Val Thr 
    290                 295                 300                 

Pro His Lys Leu Arg His Thr Leu Ala Thr Arg Leu Tyr Asp Ala Thr 
305                 310                 315                 320 

Lys Ser Gln Val Leu Val Ser His Gln Leu Gly His Ala Ser Thr Gln 
                325                 330                 335     

Val Thr Asp Leu Tyr Thr His Ile Val Ser Asp Glu Gln Lys Asn Ala 
            340                 345                 350         

Leu Asp Ser Leu 
        355     

<210>   2317
<211>   987
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2317
atgaaataca ttatcaatca ttcaaatgac actgctttta atattgcctt ggaagaatac   60
gcctttaaac accttttgga tgaggatcaa atcttcctac tttggattaa caagccatct   120
atcattgttg gtcgtcacca gaacactatc gaagaaatca accgtgatta tgttcgcgaa   180
aatggtattg aggtagttcg ccgtattagt ggtggtggag ctgtttacca cgatttaaat   240
aacctcaact acacgatcat ctccaaagaa gatgaaaata aggcatttga cttcaagagc   300
ttctcaactc cggttatcaa taccctggct caacttgggg ttaaagctga gttcacaggt   360
cgtaatgacc ttgagattga tggtaagaag ttctgtggca atgcccaagc ctatatcaac   420
ggccgtatca tgcaccacgg ttgcttgctc tttgacgttg atttgtcagt cctcgcaaat   480
gcccttaagg tttcaaaaga taaatttgaa tcaaaaggtg tgaaatccgt ccgtgcccgt   540
gtaaccaata ttatcaatga attaccaaaa aaaatcacag tcgaaaaatt ccgtgattta   600
ctcttggaat acatgaaaaa agagtaccca gagatgactg aatacgtctt ttcagaagaa   660
gaattggccg aaatcaatcg catcaaggat actaagtttg gaacttggga ctggaactat   720
ggtaaatcac ctgaatttaa cgtccgtcgt ggaatcaaat tcactagtgg taaggttgaa   780
gtctttgcta acgttactga atcaaaaatc caagacatca agatttatgg tgacttcttt   840
ggtattgaag acgttgctgc agtagaagat gtccttcgtg gggtgaaata cgaacgcgaa   900
gatgttctta aggcgctaaa aaccattgat atcacacgct acttcgctgg tattagccgt   960
gaagaaatcg ctgaagcggt agttgga                                       987

<210>   2318
<211>   329
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lipoate-protein ligase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903091 (0.E+01)

<400>   2318
Met Lys Tyr Ile Ile Asn His Ser Asn Asp Thr Ala Phe Asn Ile Ala 
1               5                   10                  15      

Leu Glu Glu Tyr Ala Phe Lys His Leu Leu Asp Glu Asp Gln Ile Phe 
            20                  25                  30          

Leu Leu Trp Ile Asn Lys Pro Ser Ile Ile Val Gly Arg His Gln Asn 
        35                  40                  45              

Thr Ile Glu Glu Ile Asn Arg Asp Tyr Val Arg Glu Asn Gly Ile Glu 
    50                  55                  60                  

Val Val Arg Arg Ile Ser Gly Gly Gly Ala Val Tyr His Asp Leu Asn 
65                  70                  75                  80  

Asn Leu Asn Tyr Thr Ile Ile Ser Lys Glu Asp Glu Asn Lys Ala Phe 
                85                  90                  95      

Asp Phe Lys Ser Phe Ser Thr Pro Val Ile Asn Thr Leu Ala Gln Leu 
            100                 105                 110         

Gly Val Lys Ala Glu Phe Thr Gly Arg Asn Asp Leu Glu Ile Asp Gly 
        115                 120                 125             

Lys Lys Phe Cys Gly Asn Ala Gln Ala Tyr Ile Asn Gly Arg Ile Met 
    130                 135                 140                 

His His Gly Cys Leu Leu Phe Asp Val Asp Leu Ser Val Leu Ala Asn 
145                 150                 155                 160 

Ala Leu Lys Val Ser Lys Asp Lys Phe Glu Ser Lys Gly Val Lys Ser 
                165                 170                 175     

Val Arg Ala Arg Val Thr Asn Ile Ile Asn Glu Leu Pro Lys Lys Ile 
            180                 185                 190         

Thr Val Glu Lys Phe Arg Asp Leu Leu Leu Glu Tyr Met Lys Lys Glu 
        195                 200                 205             

Tyr Pro Glu Met Thr Glu Tyr Val Phe Ser Glu Glu Glu Leu Ala Glu 
    210                 215                 220                 

Ile Asn Arg Ile Lys Asp Thr Lys Phe Gly Thr Trp Asp Trp Asn Tyr 
225                 230                 235                 240 

Gly Lys Ser Pro Glu Phe Asn Val Arg Arg Gly Ile Lys Phe Thr Ser 
                245                 250                 255     

Gly Lys Val Glu Val Phe Ala Asn Val Thr Glu Ser Lys Ile Gln Asp 
            260                 265                 270         

Ile Lys Ile Tyr Gly Asp Phe Phe Gly Ile Glu Asp Val Ala Ala Val 
        275                 280                 285             

Glu Asp Val Leu Arg Gly Val Lys Tyr Glu Arg Glu Asp Val Leu Lys 
    290                 295                 300                 

Ala Leu Lys Thr Ile Asp Ile Thr Arg Tyr Phe Ala Gly Ile Ser Arg 
305                 310                 315                 320 

Glu Glu Ile Ala Glu Ala Val Val Gly 
                325                 

<210>   2319
<211>   1701
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2319
atggccttag aagtaattat gccaaaagcc ggcgtggata tgacagaagg acaaatcgtc   60
caatggaata aaaaagtcgg agaatttgta aaagaaggag aaatcctttt ggaaatcatg   120
actgataaag tcagcatgga attggaagcc gaagaagatg ggtacttgat tgccattctc   180
aaaggagatg gtgaaactgt ccctgtaacg gaagttatcg gttaccttgg tgaagaaagg   240
gaaaacatcc caacagctgg agcagcatcg ccagaagcta gccctgtacc tgtagcaagt   300
acctcaaacg atgatggtaa gagcgatgat gcttttgata tcgttgtgat tggtggaggt   360
cctgctggtt atgttgcagc cattaaagct gcccaattcg gcggtaaggt tgcccttgtt   420
gagaaatctg aacttggtgg aacctgctta aaccgtggat gtattccaac caagacctac   480
cttcataacg ctgaaattat tgaaaatatc ggtcatgctg caaatcgtgg tatcgtgatt   540
gaaaatccta acttcactgt tgatatggaa aaacttttag aaactaaatc taaagttgtt   600
aatactcttg ttggtggtgt tgcaggactt cttcgtagct acggagttac tgttcataaa   660
ggaattggta caatcactaa agacaagaac gtcttggtaa atggttctga attgcttgaa   720
accaagaaaa tcattcttgc tggtggttca aaagtcaaca agatcaacgt ccctggtatg   780
gaatctccac ttgtcatgac tagtgatgac attcttgaaa tgaacgaagt gccagaaagc   840
cttgttatca tcggtggtgg agttgtcggt atcgaactcg gtcaggcctt catgacattt   900
ggttcaaaag tgactgttat cgaaatgatg gaccgtatag ttccagctat ggatgtggaa   960
gtttctaaga accttcgctt gattcttgag cgtaaaggaa tgaccatctt gactggtact   1020
aaactgcaag aaatcattga ggaaaatggt caacttcgta tcaaggttga aggaaaagac   1080
gatatcatcg caagcaaagc tcttctttca attggtcgta tgccagacct tgaaggtatt   1140
ggagaggttg agtttgaatt ggatcgtggt tgtatcaagg tcaacgaata catggaaact   1200
tcagttccag gcatttatgc accaggtgac atcaacggta ctaagatgtt ggctcacgca   1260
gctttccgca tgggtgaagt ttccgctgaa aatgccctta aaggaaatca tgcagttgcc   1320
aaattgaatt tgactcctgc agccatctac actctccctg aagtagcagc agtaggtttg   1380
acagaagaac aagcccgtga gaaatacgat gttgccatcg gtaagtttaa ctttgctgct   1440
aacggtcgtg ctattgcatc tgacgcagct caaggtttcg taaaagttat cgctgataag   1500
aaatacggag aaatccttgg tgtacacatt attggtcctg cagccgcaga attaataaac   1560
gaagcatcaa gcatcatcga aatggaaatc actgttgagg aaatgctgaa gaccatccac   1620
gggcacccaa cttactctga agtgatgtac gaagcgtttg cagatgttct aggaatggcc   1680
atccattcac ctaagaaaaa a                                             1701

<210>   2320
<211>   567
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetoin dehydrogenase complex, E3 component, dihydrolipoamide dehydroge
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903092 (0.E+01)

<400>   2320
Met Ala Leu Glu Val Ile Met Pro Lys Ala Gly Val Asp Met Thr Glu 
1               5                   10                  15      

Gly Gln Ile Val Gln Trp Asn Lys Lys Val Gly Glu Phe Val Lys Glu 
            20                  25                  30          

Gly Glu Ile Leu Leu Glu Ile Met Thr Asp Lys Val Ser Met Glu Leu 
        35                  40                  45              

Glu Ala Glu Glu Asp Gly Tyr Leu Ile Ala Ile Leu Lys Gly Asp Gly 
    50                  55                  60                  

Glu Thr Val Pro Val Thr Glu Val Ile Gly Tyr Leu Gly Glu Glu Arg 
65                  70                  75                  80  

Glu Asn Ile Pro Thr Ala Gly Ala Ala Ser Pro Glu Ala Ser Pro Val 
                85                  90                  95      

Pro Val Ala Ser Thr Ser Asn Asp Asp Gly Lys Ser Asp Asp Ala Phe 
            100                 105                 110         

Asp Ile Val Val Ile Gly Gly Gly Pro Ala Gly Tyr Val Ala Ala Ile 
        115                 120                 125             

Lys Ala Ala Gln Phe Gly Gly Lys Val Ala Leu Val Glu Lys Ser Glu 
    130                 135                 140                 

Leu Gly Gly Thr Cys Leu Asn Arg Gly Cys Ile Pro Thr Lys Thr Tyr 
145                 150                 155                 160 

Leu His Asn Ala Glu Ile Ile Glu Asn Ile Gly His Ala Ala Asn Arg 
                165                 170                 175     

Gly Ile Val Ile Glu Asn Pro Asn Phe Thr Val Asp Met Glu Lys Leu 
            180                 185                 190         

Leu Glu Thr Lys Ser Lys Val Val Asn Thr Leu Val Gly Gly Val Ala 
        195                 200                 205             

Gly Leu Leu Arg Ser Tyr Gly Val Thr Val His Lys Gly Ile Gly Thr 
    210                 215                 220                 

Ile Thr Lys Asp Lys Asn Val Leu Val Asn Gly Ser Glu Leu Leu Glu 
225                 230                 235                 240 

Thr Lys Lys Ile Ile Leu Ala Gly Gly Ser Lys Val Asn Lys Ile Asn 
                245                 250                 255     

Val Pro Gly Met Glu Ser Pro Leu Val Met Thr Ser Asp Asp Ile Leu 
            260                 265                 270         

Glu Met Asn Glu Val Pro Glu Ser Leu Val Ile Ile Gly Gly Gly Val 
        275                 280                 285             

Val Gly Ile Glu Leu Gly Gln Ala Phe Met Thr Phe Gly Ser Lys Val 
    290                 295                 300                 

Thr Val Ile Glu Met Met Asp Arg Ile Val Pro Ala Met Asp Val Glu 
305                 310                 315                 320 

Val Ser Lys Asn Leu Arg Leu Ile Leu Glu Arg Lys Gly Met Thr Ile 
                325                 330                 335     

Leu Thr Gly Thr Lys Leu Gln Glu Ile Ile Glu Glu Asn Gly Gln Leu 
            340                 345                 350         

Arg Ile Lys Val Glu Gly Lys Asp Asp Ile Ile Ala Ser Lys Ala Leu 
        355                 360                 365             

Leu Ser Ile Gly Arg Met Pro Asp Leu Glu Gly Ile Gly Glu Val Glu 
    370                 375                 380                 

Phe Glu Leu Asp Arg Gly Cys Ile Lys Val Asn Glu Tyr Met Glu Thr 
385                 390                 395                 400 

Ser Val Pro Gly Ile Tyr Ala Pro Gly Asp Ile Asn Gly Thr Lys Met 
                405                 410                 415     

Leu Ala His Ala Ala Phe Arg Met Gly Glu Val Ser Ala Glu Asn Ala 
            420                 425                 430         

Leu Lys Gly Asn His Ala Val Ala Lys Leu Asn Leu Thr Pro Ala Ala 
        435                 440                 445             

Ile Tyr Thr Leu Pro Glu Val Ala Ala Val Gly Leu Thr Glu Glu Gln 
    450                 455                 460                 

Ala Arg Glu Lys Tyr Asp Val Ala Ile Gly Lys Phe Asn Phe Ala Ala 
465                 470                 475                 480 

Asn Gly Arg Ala Ile Ala Ser Asp Ala Ala Gln Gly Phe Val Lys Val 
                485                 490                 495     

Ile Ala Asp Lys Lys Tyr Gly Glu Ile Leu Gly Val His Ile Ile Gly 
            500                 505                 510         

Pro Ala Ala Ala Glu Leu Ile Asn Glu Ala Ser Ser Ile Ile Glu Met 
        515                 520                 525             

Glu Ile Thr Val Glu Glu Met Leu Lys Thr Ile His Gly His Pro Thr 
    530                 535                 540                 

Tyr Ser Glu Val Met Tyr Glu Ala Phe Ala Asp Val Leu Gly Met Ala 
545                 550                 555                 560 

Ile His Ser Pro Lys Lys Lys 
                565         

<210>   2321
<211>   1041
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2321
atggctgatg acaagctaag agcgactcct gcagctagaa agttagcgga tgatttaggg   60
ataaacctct acgacgtttc tggctcaggt gcaaacggtc gtgtccacaa agaagacgtg   120
gaaacttata aagacacaaa cgtggttcgc atttcgccac ttgcaaaacg aattgccctc   180
gaacataaca ttgcttggca ggaaatccaa ggaaccggtc atcgtggtaa aatcatgaag   240
aaggatgttt tggccctgct tcctgaaaat atcgaaaacg atagcatcaa atctcctgct   300
cagattgaaa aagtggaaga agtccctgat aacgtaacac catatggtaa aatcgagcgt   360
attccaatga caccaatgcg taaggttatt gcccaacgca tggttgaatc ttacttgact   420
gcgccaacct tcaccctcaa ctatgaagtt gatatgactg aaatgttggc tcttcgtaag   480
aaggttcttg agccaatcat ggaagcaact gggaagaaga ctactgtaac agaccttctt   540
tcgcttgcag ttgttaagac tcttatgaaa cacccataca tcaacgcttc attgacagaa   600
gatggcaaga ctattatcac tcacaactat gtcaatcttg ccatggcagt tgggatggat   660
aatggattga tgacacctgt tgtttacaat gctgagaaga tgagtctttc agaactggtt   720
gtagccttta aggatgttat tggccgtacc ttggatggta aattggctcc aagtgagtta   780
caaaattcaa cattcacaat cagtaatttg ggaatgtttg gtgttcagtc ctttggtccg   840
attattaacc aacccaactc agctatcctt ggtgtcagtt cgacaatcga gaagccagtt   900
gtcgtcaatg gtgaaattgt gattcgccca atcatgagtt taggattaac cattgaccac   960
cgtgtcgtag atggtatggc tggtgctaag tttatgaagg acttgaaaga gttgattgaa   1020
acgccaatct caatgttaat t                                             1041

<210>   2322
<211>   347
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetoin dehydrogenase complex, E2 component, dihydrolipoamide acetyltra
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903093 (0.E+01)

<400>   2322
Met Ala Asp Asp Lys Leu Arg Ala Thr Pro Ala Ala Arg Lys Leu Ala 
1               5                   10                  15      

Asp Asp Leu Gly Ile Asn Leu Tyr Asp Val Ser Gly Ser Gly Ala Asn 
            20                  25                  30          

Gly Arg Val His Lys Glu Asp Val Glu Thr Tyr Lys Asp Thr Asn Val 
        35                  40                  45              

Val Arg Ile Ser Pro Leu Ala Lys Arg Ile Ala Leu Glu His Asn Ile 
    50                  55                  60                  

Ala Trp Gln Glu Ile Gln Gly Thr Gly His Arg Gly Lys Ile Met Lys 
65                  70                  75                  80  

Lys Asp Val Leu Ala Leu Leu Pro Glu Asn Ile Glu Asn Asp Ser Ile 
                85                  90                  95      

Lys Ser Pro Ala Gln Ile Glu Lys Val Glu Glu Val Pro Asp Asn Val 
            100                 105                 110         

Thr Pro Tyr Gly Lys Ile Glu Arg Ile Pro Met Thr Pro Met Arg Lys 
        115                 120                 125             

Val Ile Ala Gln Arg Met Val Glu Ser Tyr Leu Thr Ala Pro Thr Phe 
    130                 135                 140                 

Thr Leu Asn Tyr Glu Val Asp Met Thr Glu Met Leu Ala Leu Arg Lys 
145                 150                 155                 160 

Lys Val Leu Glu Pro Ile Met Glu Ala Thr Gly Lys Lys Thr Thr Val 
                165                 170                 175     

Thr Asp Leu Leu Ser Leu Ala Val Val Lys Thr Leu Met Lys His Pro 
            180                 185                 190         

Tyr Ile Asn Ala Ser Leu Thr Glu Asp Gly Lys Thr Ile Ile Thr His 
        195                 200                 205             

Asn Tyr Val Asn Leu Ala Met Ala Val Gly Met Asp Asn Gly Leu Met 
    210                 215                 220                 

Thr Pro Val Val Tyr Asn Ala Glu Lys Met Ser Leu Ser Glu Leu Val 
225                 230                 235                 240 

Val Ala Phe Lys Asp Val Ile Gly Arg Thr Leu Asp Gly Lys Leu Ala 
                245                 250                 255     

Pro Ser Glu Leu Gln Asn Ser Thr Phe Thr Ile Ser Asn Leu Gly Met 
            260                 265                 270         

Phe Gly Val Gln Ser Phe Gly Pro Ile Ile Asn Gln Pro Asn Ser Ala 
        275                 280                 285             

Ile Leu Gly Val Ser Ser Thr Ile Glu Lys Pro Val Val Val Asn Gly 
    290                 295                 300                 

Glu Ile Val Ile Arg Pro Ile Met Ser Leu Gly Leu Thr Ile Asp His 
305                 310                 315                 320 

Arg Val Val Asp Gly Met Ala Gly Ala Lys Phe Met Lys Asp Leu Lys 
                325                 330                 335     

Glu Leu Ile Glu Thr Pro Ile Ser Met Leu Ile 
            340                 345         

<210>   2323
<211>   990
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2323
atggaaacaa aaacaatgtc cttccgtgac accattatcc ttgctatgtc tgaggaaatg   60
cgtcgcgatg aaaatgtgtt cttgatggga gaagacgtcg gtgtcttcgg aggagacttc   120
ggtacttctg ttggaatgct tgaagaattt ggtccagaac gtgtccgtga ctgtccgatt   180
tctgaagctg ccatctctgg agcagcagca ggagcagcca tgacaggact tcgtccaatc   240
gtcgatatga ccttcatgga cttctctgtt attgccatgg acaatatcgt caaccaagct   300
gctaaaacac gttacatgtt tggtggtaaa ggtcaggttc caatgactgt tcgttgtgca   360
gctggtaacg gagttggctc tgccgcccag cactcacaat ctctagagtc ttggtttact   420
cacattccag gacttaaggt tgtggcacct ggaacacctg cggacatgaa aggcctgctt   480
aagtcttcta tccgtgataa caacccagtt attatacttg agtacaagtc agaatttaac   540
caaaaagggg aagtgccagt tgatccagac tacacaattc cacttggggt tggtgaaatc   600
aaacgccaag gaacggatgt aacagttgtt acttatggaa aaatgcttcg ccgtgtggtt   660
caagctgctg aagaattagc agaagaagga atttcagttg aaattgttga cccacgtacc   720
cttgttccgc ttgataagga tatcatcata aactcagtga agaagactgg taaggttgtt   780
ctggtcaacg atgcccacaa aacaagtggc tatatcggtg aaatttcagc tattatttca   840
gaatcagaag catttgacta tctagatgca ccaattcgcc gttgtgcagg agaagatgtg   900
ccgatgcctt atgcacaaaa cctagaaaat gcaatgattc caacagttga aagtatcaaa   960
gatgcaatcc gaaaaactta taacaaagaa                                    990

<210>   2324
<211>   330
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetoin dehydrogenase, E1 component, beta subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903094 (0.E+01)

<400>   2324
Met Glu Thr Lys Thr Met Ser Phe Arg Asp Thr Ile Ile Leu Ala Met 
1               5                   10                  15      

Ser Glu Glu Met Arg Arg Asp Glu Asn Val Phe Leu Met Gly Glu Asp 
            20                  25                  30          

Val Gly Val Phe Gly Gly Asp Phe Gly Thr Ser Val Gly Met Leu Glu 
        35                  40                  45              

Glu Phe Gly Pro Glu Arg Val Arg Asp Cys Pro Ile Ser Glu Ala Ala 
    50                  55                  60                  

Ile Ser Gly Ala Ala Ala Gly Ala Ala Met Thr Gly Leu Arg Pro Ile 
65                  70                  75                  80  

Val Asp Met Thr Phe Met Asp Phe Ser Val Ile Ala Met Asp Asn Ile 
                85                  90                  95      

Val Asn Gln Ala Ala Lys Thr Arg Tyr Met Phe Gly Gly Lys Gly Gln 
            100                 105                 110         

Val Pro Met Thr Val Arg Cys Ala Ala Gly Asn Gly Val Gly Ser Ala 
        115                 120                 125             

Ala Gln His Ser Gln Ser Leu Glu Ser Trp Phe Thr His Ile Pro Gly 
    130                 135                 140                 

Leu Lys Val Val Ala Pro Gly Thr Pro Ala Asp Met Lys Gly Leu Leu 
145                 150                 155                 160 

Lys Ser Ser Ile Arg Asp Asn Asn Pro Val Ile Ile Leu Glu Tyr Lys 
                165                 170                 175     

Ser Glu Phe Asn Gln Lys Gly Glu Val Pro Val Asp Pro Asp Tyr Thr 
            180                 185                 190         

Ile Pro Leu Gly Val Gly Glu Ile Lys Arg Gln Gly Thr Asp Val Thr 
        195                 200                 205             

Val Val Thr Tyr Gly Lys Met Leu Arg Arg Val Val Gln Ala Ala Glu 
    210                 215                 220                 

Glu Leu Ala Glu Glu Gly Ile Ser Val Glu Ile Val Asp Pro Arg Thr 
225                 230                 235                 240 

Leu Val Pro Leu Asp Lys Asp Ile Ile Ile Asn Ser Val Lys Lys Thr 
                245                 250                 255     

Gly Lys Val Val Leu Val Asn Asp Ala His Lys Thr Ser Gly Tyr Ile 
            260                 265                 270         

Gly Glu Ile Ser Ala Ile Ile Ser Glu Ser Glu Ala Phe Asp Tyr Leu 
        275                 280                 285             

Asp Ala Pro Ile Arg Arg Cys Ala Gly Glu Asp Val Pro Met Pro Tyr 
    290                 295                 300                 

Ala Gln Asn Leu Glu Asn Ala Met Ile Pro Thr Val Glu Ser Ile Lys 
305                 310                 315                 320 

Asp Ala Ile Arg Lys Thr Tyr Asn Lys Glu 
                325                 330 

<210>   2325
<211>   966
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2325
atgtcaactt tagataaaaa tcttttgcta gaaatgttcc gtaagatgga agaaatccgt   60
cgcatggact taaaaattgc acaattagta aagaaaggga aagtgccagg aatgacgcac   120
ttttctgttg gtgaagaggc agctaacgtg ggggctatgt tagctctcaa tccagatgat   180
ctgattacct caaaccaccg tggacacggg caagctattg ctaaagggat tgacctcaac   240
ggaatgatgg ctgaaatcct tggtaaatac actggaacct gtaaagggaa aggtggatct   300
atgcatatcg ctgaccttga tgctgggaac cttggtgcca atggtatcgt aggtggtggt   360
atggggatcg ctgtcggtgc agccctcagt cagcaaatgc aaaataccgg taaaatcgtt   420
gtctgcttct ttggagatgg tgcgaccaat gaaggtgttt tccacgaagc agtgaacatg   480
gcttctatct ggaacctgcc agtcattttc tattgcatta acaacggtta cggtatctct   540
gcggatatca agaaaatgac caatatagaa catatccatc aacgtagcgc cgcttatgga   600
attcctggaa tgttcatcga agacggtaac aatgtcatcg atgtctatga aggatttcag   660
aaagctgtgg accatgttcg cagtggcaat ggtccagtct tgattgaaag tgtaacttat   720
cgctggctcg gtcactcatc atctgaccct ggtaaatatc gtacgcgtga agaagtggaa   780
ttgtggaaac aaaaagatcc aatcgaaaac ctccgcaatt accttattga aaataacatt   840
gcaagtgccg aagaattgga agaaatccaa gcgcaagtaa aggaagcagt agaagcttct   900
gttaaatttg cagaggaaag cccattccca ccgcttgaat cagcctttga agatatttac   960
gcagac                                                              966

<210>   2326
<211>   322
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetoin dehydrogenase, E1 component, alpha subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903095 (0.E+01)

<400>   2326
Met Ser Thr Leu Asp Lys Asn Leu Leu Leu Glu Met Phe Arg Lys Met 
1               5                   10                  15      

Glu Glu Ile Arg Arg Met Asp Leu Lys Ile Ala Gln Leu Val Lys Lys 
            20                  25                  30          

Gly Lys Val Pro Gly Met Thr His Phe Ser Val Gly Glu Glu Ala Ala 
        35                  40                  45              

Asn Val Gly Ala Met Leu Ala Leu Asn Pro Asp Asp Leu Ile Thr Ser 
    50                  55                  60                  

Asn His Arg Gly His Gly Gln Ala Ile Ala Lys Gly Ile Asp Leu Asn 
65                  70                  75                  80  

Gly Met Met Ala Glu Ile Leu Gly Lys Tyr Thr Gly Thr Cys Lys Gly 
                85                  90                  95      

Lys Gly Gly Ser Met His Ile Ala Asp Leu Asp Ala Gly Asn Leu Gly 
            100                 105                 110         

Ala Asn Gly Ile Val Gly Gly Gly Met Gly Ile Ala Val Gly Ala Ala 
        115                 120                 125             

Leu Ser Gln Gln Met Gln Asn Thr Gly Lys Ile Val Val Cys Phe Phe 
    130                 135                 140                 

Gly Asp Gly Ala Thr Asn Glu Gly Val Phe His Glu Ala Val Asn Met 
145                 150                 155                 160 

Ala Ser Ile Trp Asn Leu Pro Val Ile Phe Tyr Cys Ile Asn Asn Gly 
                165                 170                 175     

Tyr Gly Ile Ser Ala Asp Ile Lys Lys Met Thr Asn Ile Glu His Ile 
            180                 185                 190         

His Gln Arg Ser Ala Ala Tyr Gly Ile Pro Gly Met Phe Ile Glu Asp 
        195                 200                 205             

Gly Asn Asn Val Ile Asp Val Tyr Glu Gly Phe Gln Lys Ala Val Asp 
    210                 215                 220                 

His Val Arg Ser Gly Asn Gly Pro Val Leu Ile Glu Ser Val Thr Tyr 
225                 230                 235                 240 

Arg Trp Leu Gly His Ser Ser Ser Asp Pro Gly Lys Tyr Arg Thr Arg 
                245                 250                 255     

Glu Glu Val Glu Leu Trp Lys Gln Lys Asp Pro Ile Glu Asn Leu Arg 
            260                 265                 270         

Asn Tyr Leu Ile Glu Asn Asn Ile Ala Ser Ala Glu Glu Leu Glu Glu 
        275                 280                 285             


Ile Gln Ala Gln Val Lys Glu Ala Val Glu Ala Ser Val Lys Phe Ala 
    290                 295                 300                 

Glu Glu Ser Pro Phe Pro Pro Leu Glu Ser Ala Phe Glu Asp Ile Tyr 
305                 310                 315                 320 

Ala Asp 
        

<210>   2327
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2327
ttggcaaata ctgtcaaagt ttttctaaaa gaaatttcac aaaataaaaa agaaaacccc   60
gtgaaaacaa gggattttct tgtcaagaat attttttcac aaactttt                108

<210>   2328
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2328
Met Ala Asn Thr Val Lys Val Phe Leu Lys Glu Ile Ser Gln Asn Lys 
1               5                   10                  15      

Lys Glu Asn Pro Val Lys Thr Arg Asp Phe Leu Val Lys Asn Ile Phe 
            20                  25                  30          

Ser Gln Thr Phe 
        35      

<210>   2329
<211>   1359
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2329
atgtataaga caaagtgttt acgagagaag ttagtattat ttttaaaaat tttcttccca   60
atcctgatct accaatttgc caattattct gcctcttttg ttgatactgc aatgacaggt   120
caatacaaca ctatggactt ggctggtgta tctatggcaa ccagtatctg gaatcctttc   180
tttacatttc taacagggat tgtgtcagcc ttggtgccta tcattggtca ccatcttggt   240
cgaggcaaaa aggaagaagt tgcgtctgat ttttaccaat ttatttattt ggccttgggc   300
ctatctgtgg tcttgctggg gatggtactt ttcttggcac caataatctt gaatcatatt   360
gggttagaag cagcagtagc ggcagtagcg gttcgctatc tttggttttt atctatcggg   420
attatcccct tgttgctctt tagcgtcatt cgttccttgc tggattcgct gggcttgacc   480
aaactgtcca tgtacctcat gcttttgtta ctccctctca atagcggatt taactatctc   540
ttgatttacg gtgcctttgg tgttccagaa ctgggagggg ctggtgctgg tttaggaaca   600
tccttggcct actgggtctt gcttgggatt tctgttctgg ttttatttaa acaggagaag   660
ctcaaagcct tacaccttga gaaacgaatt ccacttaata tggataaaat taaggaagga   720
gttcgtttag gtctgcctat tgggggaact gtcttcgcgg aagtggctat cttttcagtg   780
gttggcttga ttatggctaa gttttcgccc ttgattatag ctagtcacca gtcagctatg   840
aacttttcaa gtcttatgta cgcctttcct atgagtatct catcggctat ggctattgtc   900
gtttcctatg aagtgggagc caagcgattt gatgatgcga aaacctatat tggtctagga   960
agatggactg ccctcatttt tgcggccttc accttaacct tcctttacat ttttagggga   1020
aatgtggcca gtctttatgg taacgaccca aaatttatcg atttgacagt gcgtttttta   1080
acttatagtc ttttcttcca gttagcagat acctttgcgg cgccgcttca gggaattttg   1140
cgggggtata aggatacagt tattcctttt taccttggtt tgcttggtta ttggggcgta   1200
gcaatccctg tgcgtacgct atttgattcc ctaacagatt ttggagctta ttcttactgg   1260
atcggcttga ttattagttt gattgtgagc ggggcgctct accgttggcg tttaactgtg   1320
attatgaaga gatttgaatc tttagcaaaa tccaaatgc                          1359

<210>   2330
<211>   453
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MATE efflux family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903096 (0.E+01)

<400>   2330
Met Tyr Lys Thr Lys Cys Leu Arg Glu Lys Leu Val Leu Phe Leu Lys 
1               5                   10                  15      

Ile Phe Phe Pro Ile Leu Ile Tyr Gln Phe Ala Asn Tyr Ser Ala Ser 
            20                  25                  30          

Phe Val Asp Thr Ala Met Thr Gly Gln Tyr Asn Thr Met Asp Leu Ala 
        35                  40                  45              

Gly Val Ser Met Ala Thr Ser Ile Trp Asn Pro Phe Phe Thr Phe Leu 
    50                  55                  60                  

Thr Gly Ile Val Ser Ala Leu Val Pro Ile Ile Gly His His Leu Gly 
65                  70                  75                  80  

Arg Gly Lys Lys Glu Glu Val Ala Ser Asp Phe Tyr Gln Phe Ile Tyr 
                85                  90                  95      

Leu Ala Leu Gly Leu Ser Val Val Leu Leu Gly Met Val Leu Phe Leu 
            100                 105                 110         

Ala Pro Ile Ile Leu Asn His Ile Gly Leu Glu Ala Ala Val Ala Ala 
        115                 120                 125             

Val Ala Val Arg Tyr Leu Trp Phe Leu Ser Ile Gly Ile Ile Pro Leu 
    130                 135                 140                 

Leu Leu Phe Ser Val Ile Arg Ser Leu Leu Asp Ser Leu Gly Leu Thr 
145                 150                 155                 160 

Lys Leu Ser Met Tyr Leu Met Leu Leu Leu Leu Pro Leu Asn Ser Gly 
                165                 170                 175     

Phe Asn Tyr Leu Leu Ile Tyr Gly Ala Phe Gly Val Pro Glu Leu Gly 
            180                 185                 190         

Gly Ala Gly Ala Gly Leu Gly Thr Ser Leu Ala Tyr Trp Val Leu Leu 
        195                 200                 205             

Gly Ile Ser Val Leu Val Leu Phe Lys Gln Glu Lys Leu Lys Ala Leu 
    210                 215                 220                 

His Leu Glu Lys Arg Ile Pro Leu Asn Met Asp Lys Ile Lys Glu Gly 
225                 230                 235                 240 

Val Arg Leu Gly Leu Pro Ile Gly Gly Thr Val Phe Ala Glu Val Ala 
                245                 250                 255     

Ile Phe Ser Val Val Gly Leu Ile Met Ala Lys Phe Ser Pro Leu Ile 
            260                 265                 270         

Ile Ala Ser His Gln Ser Ala Met Asn Phe Ser Ser Leu Met Tyr Ala 
        275                 280                 285             

Phe Pro Met Ser Ile Ser Ser Ala Met Ala Ile Val Val Ser Tyr Glu 
    290                 295                 300                 

Val Gly Ala Lys Arg Phe Asp Asp Ala Lys Thr Tyr Ile Gly Leu Gly 
305                 310                 315                 320 

Arg Trp Thr Ala Leu Ile Phe Ala Ala Phe Thr Leu Thr Phe Leu Tyr 
                325                 330                 335     

Ile Phe Arg Gly Asn Val Ala Ser Leu Tyr Gly Asn Asp Pro Lys Phe 
            340                 345                 350         

Ile Asp Leu Thr Val Arg Phe Leu Thr Tyr Ser Leu Phe Phe Gln Leu 

        355                 360                 365             

Ala Asp Thr Phe Ala Ala Pro Leu Gln Gly Ile Leu Arg Gly Tyr Lys 
    370                 375                 380                 

Asp Thr Val Ile Pro Phe Tyr Leu Gly Leu Leu Gly Tyr Trp Gly Val 
385                 390                 395                 400 

Ala Ile Pro Val Arg Thr Leu Phe Asp Ser Leu Thr Asp Phe Gly Ala 
                405                 410                 415     

Tyr Ser Tyr Trp Ile Gly Leu Ile Ile Ser Leu Ile Val Ser Gly Ala 
            420                 425                 430         

Leu Tyr Arg Trp Arg Leu Thr Val Ile Met Lys Arg Phe Glu Ser Leu 
        435                 440                 445             

Ala Lys Ser Lys Cys 
    450             

<210>   2331
<211>   1266
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2331
atgctactaa tcaaaaatgg tcgtgtaatg gatcccaagt ctggtttgga tcaagtttgt   60
gatgtcttag ttcaagatgg gaaaattatc aaaattgcgt ctgagatcac ggaagaagga   120
gcagaaacga ttgatgctac tggtcttgtg gttgctcctg gcttggtcga tattcatgtt   180
catttccgtg aacctggtca aacacataaa gaagacattc atactggtgc cctagcagcc   240
gctgcaggtg gttttactac tgtcgtcatg atggctaata ccagtccaac catttcagac   300
gtggagactt tgcaagcagt tctccagtca gctgccaaag agaagattaa tgtcaagaca   360
gttgcgacca ttactaaaaa ctttaatggt aaaaacttga ctgactttaa ggcactctta   420
gaagctggtg cggttggttt ctctgatgac ggtattccgc ttgagagcag taagattgtc   480
aaggaagcca tggaggaagc caaaaaactc aataccttta tcagccttca tgaggaagat   540
ccaggtttga acggtgttct tggctttaat gaaaatattg ctagagaaca tttccatatc   600
tgcggtgcta ctggggtggc tgagtacgct atgatggcgc gtgatgtcat gattgcctat   660
gcaactaaag cccatgttca catccagcat ttgtctaagg aagaaagtgt taaagtagtg   720
gagtttgctc aggggttagg tgcagaagtc acagcagaag tagcgccaca gcatttctct   780
aagacagaag cacttctttt aacacaaggt agcaatgcta agatgaatcc accgcttcgt   840
ttggaatcag accgtcgtgc cgttatcgaa ggtctcaaat caggtgtcat cacagttatt   900
gcgactgacc acgcgcctca tcatgtagat gaaaaaaatg ttgaggatat taccaaagcg   960
ccatctggta tgactggctt agaaacatcc ctgtctctca gcttgaccta tttagtagaa   1020
gctggtgagt tgagcttgat ggaattactt gaaaaaatga catacaaccc agccaagctt   1080
tacaactttg aagcaggtta cttggctgag aatggtccag cagatatcac tatttttgat   1140
gccaaggctg accgctttgt ggactcccat tttgcttcca aagcagctaa ttcaccattc   1200
atcggtgaaa ccttaaaagg gcaggttaaa tataccatct gtaagggaca aatcgtctat   1260
caagct                                                              1266

<210>   2332
<211>   422
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydroorotase, multifunctional complex type (pyrC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903097 (0.E+01)

<400>   2332
Met Leu Leu Ile Lys Asn Gly Arg Val Met Asp Pro Lys Ser Gly Leu 
1               5                   10                  15      

Asp Gln Val Cys Asp Val Leu Val Gln Asp Gly Lys Ile Ile Lys Ile 
            20                  25                  30          

Ala Ser Glu Ile Thr Glu Glu Gly Ala Glu Thr Ile Asp Ala Thr Gly 
        35                  40                  45              

Leu Val Val Ala Pro Gly Leu Val Asp Ile His Val His Phe Arg Glu 
    50                  55                  60                  

Pro Gly Gln Thr His Lys Glu Asp Ile His Thr Gly Ala Leu Ala Ala 
65                  70                  75                  80  

Ala Ala Gly Gly Phe Thr Thr Val Val Met Met Ala Asn Thr Ser Pro 
                85                  90                  95      

Thr Ile Ser Asp Val Glu Thr Leu Gln Ala Val Leu Gln Ser Ala Ala 
            100                 105                 110         


Lys Glu Lys Ile Asn Val Lys Thr Val Ala Thr Ile Thr Lys Asn Phe 
        115                 120                 125             

Asn Gly Lys Asn Leu Thr Asp Phe Lys Ala Leu Leu Glu Ala Gly Ala 
    130                 135                 140                 

Val Gly Phe Ser Asp Asp Gly Ile Pro Leu Glu Ser Ser Lys Ile Val 
145                 150                 155                 160 

Lys Glu Ala Met Glu Glu Ala Lys Lys Leu Asn Thr Phe Ile Ser Leu 
                165                 170                 175     

His Glu Glu Asp Pro Gly Leu Asn Gly Val Leu Gly Phe Asn Glu Asn 
            180                 185                 190         

Ile Ala Arg Glu His Phe His Ile Cys Gly Ala Thr Gly Val Ala Glu 
        195                 200                 205             

Tyr Ala Met Met Ala Arg Asp Val Met Ile Ala Tyr Ala Thr Lys Ala 
    210                 215                 220                 

His Val His Ile Gln His Leu Ser Lys Glu Glu Ser Val Lys Val Val 
225                 230                 235                 240 

Glu Phe Ala Gln Gly Leu Gly Ala Glu Val Thr Ala Glu Val Ala Pro 
                245                 250                 255     

Gln His Phe Ser Lys Thr Glu Ala Leu Leu Leu Thr Gln Gly Ser Asn 
            260                 265                 270         

Ala Lys Met Asn Pro Pro Leu Arg Leu Glu Ser Asp Arg Arg Ala Val 
        275                 280                 285             

Ile Glu Gly Leu Lys Ser Gly Val Ile Thr Val Ile Ala Thr Asp His 
    290                 295                 300                 

Ala Pro His His Val Asp Glu Lys Asn Val Glu Asp Ile Thr Lys Ala 
305                 310                 315                 320 

Pro Ser Gly Met Thr Gly Leu Glu Thr Ser Leu Ser Leu Ser Leu Thr 
                325                 330                 335     

Tyr Leu Val Glu Ala Gly Glu Leu Ser Leu Met Glu Leu Leu Glu Lys 
            340                 345                 350         

Met Thr Tyr Asn Pro Ala Lys Leu Tyr Asn Phe Glu Ala Gly Tyr Leu 
        355                 360                 365             

Ala Glu Asn Gly Pro Ala Asp Ile Thr Ile Phe Asp Ala Lys Ala Asp 
    370                 375                 380                 

Arg Phe Val Asp Ser His Phe Ala Ser Lys Ala Ala Asn Ser Pro Phe 
385                 390                 395                 400 

Ile Gly Glu Thr Leu Lys Gly Gln Val Lys Tyr Thr Ile Cys Lys Gly 
                405                 410                 415     

Gln Ile Val Tyr Gln Ala 
            420         

<210>   2333
<211>   462
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2333
atgcctcagt tagcgacgat ttgctacatt gataatggga aagaactgct catgctccat   60
cgtaataaga aacccaatga tgtccatgaa gggaaatgga ttggtgtggg tggtaagcta   120
gagagaggag agacgcccca ggaatgcgcg gcgcgtgaaa tccttgaaga aacagggctc   180
aaagccaagc cagttctaaa aggtgtcatc acttttcctg aatttacacc agatttagac   240
tggtacacct atgtttttaa ggtgacggag tttgagggcg acttgattga ctgcaatgag   300
gggacgctag aatgggttcc ctatgatgag gttttgagca agccgacttg ggaaggtgac   360
cacacctttg ttgagtggct tttagaggat aaacccttct tttcagccaa gtttgtttat   420
gatggggata aattgttgga tacccaagtt gatttctatg aa                      462

<210>   2334
<211>   154
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   mutator MutT protein (mutX)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903098 (1.E-91)

<400>   2334
Met Pro Gln Leu Ala Thr Ile Cys Tyr Ile Asp Asn Gly Lys Glu Leu 
1               5                   10                  15      

Leu Met Leu His Arg Asn Lys Lys Pro Asn Asp Val His Glu Gly Lys 
            20                  25                  30          

Trp Ile Gly Val Gly Gly Lys Leu Glu Arg Gly Glu Thr Pro Gln Glu 
        35                  40                  45              

Cys Ala Ala Arg Glu Ile Leu Glu Glu Thr Gly Leu Lys Ala Lys Pro 
    50                  55                  60                  

Val Leu Lys Gly Val Ile Thr Phe Pro Glu Phe Thr Pro Asp Leu Asp 
65                  70                  75                  80  

Trp Tyr Thr Tyr Val Phe Lys Val Thr Glu Phe Glu Gly Asp Leu Ile 
                85                  90                  95      

Asp Cys Asn Glu Gly Thr Leu Glu Trp Val Pro Tyr Asp Glu Val Leu 
            100                 105                 110         

Ser Lys Pro Thr Trp Glu Gly Asp His Thr Phe Val Glu Trp Leu Leu 
        115                 120                 125             

Glu Asp Lys Pro Phe Phe Ser Ala Lys Phe Val Tyr Asp Gly Asp Lys 
    130                 135                 140                 

Leu Leu Asp Thr Gln Val Asp Phe Tyr Glu 
145                 150                 

<210>   2335
<211>   666
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2335
atgaaggagt cggctatgga acactcgtct tggcatgctt tgattaaggc gcaattacct   60
gagggttatt tcgggaaaat caatcagttt atggagcagg tctattctca ggggattatt   120
tatccaccca aggaaaaggt ttttcaggct ctcttgacaa cactgcttga agaagttaag   180
gtggtaattc tagggcaaga cccctatcac ggaccaggtc aagcgcaggg cttgagtttt   240
tctgtacctg actctatccc agctccacca tccttgcaaa atatcttgaa agaattgtca   300
gatgatatcg gagttaagaa atctcatgat ttgacagctt gggctgagca aggagtcttg   360
cttcttaatg cttgtttgac tgttcctgct ggacaggcca atggtcatgc tggtcaaatc   420
tgggagcctt ttactgatgc tgtgattcag gtggtcaatc atctagatag accagtcgtt   480
tttgtactct ggggagctta tgcacgtaag aagaaggcat tagttaccaa tcctcatcac   540
ttgattatcg aatcagccca tccaagtcct ttgtcggttt atagaggatt ttggggttcc   600
aagccctttt ccaaggccaa tgcattctta aaagagacag gacaagagcc aatcgattgg   660
cttaga                                                              666

<210>   2336
<211>   222
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   uracil-DNA glycosylase (ung)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903099 (e-127)

<400>   2336
Met Lys Glu Ser Ala Met Glu His Ser Ser Trp His Ala Leu Ile Lys 
1               5                   10                  15      

Ala Gln Leu Pro Glu Gly Tyr Phe Gly Lys Ile Asn Gln Phe Met Glu 
            20                  25                  30          

Gln Val Tyr Ser Gln Gly Ile Ile Tyr Pro Pro Lys Glu Lys Val Phe 
        35                  40                  45              

Gln Ala Leu Leu Thr Thr Leu Leu Glu Glu Val Lys Val Val Ile Leu 
    50                  55                  60                  

Gly Gln Asp Pro Tyr His Gly Pro Gly Gln Ala Gln Gly Leu Ser Phe 
65                  70                  75                  80  

Ser Val Pro Asp Ser Ile Pro Ala Pro Pro Ser Leu Gln Asn Ile Leu 
                85                  90                  95      

Lys Glu Leu Ser Asp Asp Ile Gly Val Lys Lys Ser His Asp Leu Thr 
            100                 105                 110         

Ala Trp Ala Glu Gln Gly Val Leu Leu Leu Asn Ala Cys Leu Thr Val 
        115                 120                 125             

Pro Ala Gly Gln Ala Asn Gly His Ala Gly Gln Ile Trp Glu Pro Phe 
    130                 135                 140                 

Thr Asp Ala Val Ile Gln Val Val Asn His Leu Asp Arg Pro Val Val 
145                 150                 155                 160 

Phe Val Leu Trp Gly Ala Tyr Ala Arg Lys Lys Lys Ala Leu Val Thr 
                165                 170                 175     

Asn Pro His His Leu Ile Ile Glu Ser Ala His Pro Ser Pro Leu Ser 
            180                 185                 190         

Val Tyr Arg Gly Phe Trp Gly Ser Lys Pro Phe Ser Lys Ala Asn Ala 
        195                 200                 205             

Phe Leu Lys Glu Thr Gly Gln Glu Pro Ile Asp Trp Leu Arg 
    210                 215                 220         

<210>   2337
<211>   600
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2337
atgtctgaag ttgattttaa tgaagctgtt aattatgaat ttacatctga cacttgtcaa   60
ttagcaaata gtatttatca atctcttttt aagttttttg ataagaaaaa tttctctggc   120
gatttaattt ttacttggaa atctccatca ttagtcaaag aaggggatta tattgggaga   180
agggattcac aagtagataa tcttagagta ataggaaata tatttccgaa ttatcttact   240
aatcgaaaat atagcctcaa tatgaatcgt aatggctgta tgggagattt tcctcatgac   300
ttttttgata tatacctaga tcatgtagca aaatatgcct acgaacaaaa agttaataat   360
attaaagagt attatccttt aaaaagagcg attttacacc aagagaatgc attgtatttt   420
cgattttttt ctaattttga cgacttttta gaaaaaaatt atttaaagac tatatggcaa   480
gtttctaaag aaactccttt ttctgagatg gattttaata tgtttaaaaa tatttcagaa   540
aagataatct tcgaaagagg tagtaaaatg cttaatgatt taaaaagtaa ttataaaaaa   600

<210>   2338
<211>   200
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903100 (e-117)

<400>   2338
Met Ser Glu Val Asp Phe Asn Glu Ala Val Asn Tyr Glu Phe Thr Ser 
1               5                   10                  15      

Asp Thr Cys Gln Leu Ala Asn Ser Ile Tyr Gln Ser Leu Phe Lys Phe 
            20                  25                  30          

Phe Asp Lys Lys Asn Phe Ser Gly Asp Leu Ile Phe Thr Trp Lys Ser 
        35                  40                  45              

Pro Ser Leu Val Lys Glu Gly Asp Tyr Ile Gly Arg Arg Asp Ser Gln 
    50                  55                  60                  

Val Asp Asn Leu Arg Val Ile Gly Asn Ile Phe Pro Asn Tyr Leu Thr 
65                  70                  75                  80  

Asn Arg Lys Tyr Ser Leu Asn Met Asn Arg Asn Gly Cys Met Gly Asp 
                85                  90                  95      

Phe Pro His Asp Phe Phe Asp Ile Tyr Leu Asp His Val Ala Lys Tyr 
            100                 105                 110         

Ala Tyr Glu Gln Lys Val Asn Asn Ile Lys Glu Tyr Tyr Pro Leu Lys 
        115                 120                 125             

Arg Ala Ile Leu His Gln Glu Asn Ala Leu Tyr Phe Arg Phe Phe Ser 
    130                 135                 140                 

Asn Phe Asp Asp Phe Leu Glu Lys Asn Tyr Leu Lys Thr Ile Trp Gln 
145                 150                 155                 160 

Val Ser Lys Glu Thr Pro Phe Ser Glu Met Asp Phe Asn Met Phe Lys 
                165                 170                 175     

Asn Ile Ser Glu Lys Ile Ile Phe Glu Arg Gly Ser Lys Met Leu Asn 
            180                 185                 190         

Asp Leu Lys Ser Asn Tyr Lys Lys 
        195                 200 

<210>   2339
<211>   711
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2339
ttgttctaca aatttctact cttcgacctc gaccacactc ttcttgattt tgatgctgct   60
gaggatgtgg ctttgaccca acttctaaaa gaagaaggag ttgcggatat tcaggcttat   120
aaagattatt acgttcctat gaacaaggct ctctggaaag acttggagct gaagaaaatc   180
agtaaacaag agctggttaa cacgcgcttt tctcgtttat ttgctcattt tggacaggaa   240
aaagacggta gttttcttgc ccagcgttac caattttacc tcgcccagca gggacaaaca   300
ctatcgggcg ctcatgatct cttggacagc ctcattgagc gtgattataa cttgtatgct   360
gcgacaaatg gcattactgc cattcagaca ggacgtttgg ctcaatctgg tctagcacct   420
tatttcaatc aagtctttat ctcagaacag ttgcaaactc aaaagccgga tgctcttttt   480
tatgaaaaga ttggccagca aattgctgga tttagtaaag aaaagacgct gatgattgga   540
gattctctaa ccgccgacat tcaaggtggc aataatgcgg ggattgacac tatctggtat   600
aatcctcatc acctcgaaaa tcacacacaa gcccagccga cttacgaagt ctattcttac   660
caagacttgc tggattgttt agataaaaat attcttgaaa agatcacatt t            711


<210>   2340
<211>   237
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydrolase, haloacid dehalogenase-like family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903101 (e-135)

<400>   2340
Met Phe Tyr Lys Phe Leu Leu Phe Asp Leu Asp His Thr Leu Leu Asp 
1               5                   10                  15      

Phe Asp Ala Ala Glu Asp Val Ala Leu Thr Gln Leu Leu Lys Glu Glu 
            20                  25                  30          

Gly Val Ala Asp Ile Gln Ala Tyr Lys Asp Tyr Tyr Val Pro Met Asn 
        35                  40                  45              

Lys Ala Leu Trp Lys Asp Leu Glu Leu Lys Lys Ile Ser Lys Gln Glu 
    50                  55                  60                  

Leu Val Asn Thr Arg Phe Ser Arg Leu Phe Ala His Phe Gly Gln Glu 
65                  70                  75                  80  

Lys Asp Gly Ser Phe Leu Ala Gln Arg Tyr Gln Phe Tyr Leu Ala Gln 
                85                  90                  95      

Gln Gly Gln Thr Leu Ser Gly Ala His Asp Leu Leu Asp Ser Leu Ile 
            100                 105                 110         

Glu Arg Asp Tyr Asn Leu Tyr Ala Ala Thr Asn Gly Ile Thr Ala Ile 
        115                 120                 125             

Gln Thr Gly Arg Leu Ala Gln Ser Gly Leu Ala Pro Tyr Phe Asn Gln 
    130                 135                 140                 

Val Phe Ile Ser Glu Gln Leu Gln Thr Gln Lys Pro Asp Ala Leu Phe 
145                 150                 155                 160 

Tyr Glu Lys Ile Gly Gln Gln Ile Ala Gly Phe Ser Lys Glu Lys Thr 
                165                 170                 175     

Leu Met Ile Gly Asp Ser Leu Thr Ala Asp Ile Gln Gly Gly Asn Asn 
            180                 185                 190         

Ala Gly Ile Asp Thr Ile Trp Tyr Asn Pro His His Leu Glu Asn His 
        195                 200                 205             

Thr Gln Ala Gln Pro Thr Tyr Glu Val Tyr Ser Tyr Gln Asp Leu Leu 
    210                 215                 220                 

Asp Cys Leu Asp Lys Asn Ile Leu Glu Lys Ile Thr Phe 
225                 230                 235         

<210>   2341
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2341
ttgctttatg cagttccttt ttattttaac aggagtgaaa ctatagtgtt tctaaattgt   60
gaatcaatca aaactgattg tgatggggct attctagctt tagaaacctt caaaaat      117

<210>   2342
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2342
Met Leu Tyr Ala Val Pro Phe Tyr Phe Asn Arg Ser Glu Thr Ile Val 
1               5                   10                  15      

Phe Leu Asn Cys Glu Ser Ile Lys Thr Asp Cys Asp Gly Ala Ile Leu 
            20                  25                  30          

Ala Leu Glu Thr Phe Lys Asn 
        35                  

<210>   2343
<211>   372
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2343
atggaaagta ttggtcttgt tatcgtttca cattccaaac acattgcaga aggtgttgtt   60
gaactgatta gtaaagtagc taaagatgtt ccgattactt atgtaagagg aaccgagggc   120
ggaggaattg gaacgagttt tgaacaagta gatagggttg tttccgaaaa tccagcagat   180
actttacttg ccttttttga cctaggttct gctaaaatga acttaaaaat ggtgactgat   240
ttcagtgata aaagtatcat catcaacagg gttccaattg tagaaggtgc ctataatgca   300
gctgctcttc ttcaggctgg tgcagaactg tcagttattc aaacacagtt agcggagctt   360
gaaatcaata aa                                                       372

<210>   2344
<211>   124
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903102 (4.E-23)

<400>   2344
Met Glu Ser Ile Gly Leu Val Ile Val Ser His Ser Lys His Ile Ala 
1               5                   10                  15      

Glu Gly Val Val Glu Leu Ile Ser Lys Val Ala Lys Asp Val Pro Ile 
            20                  25                  30          

Thr Tyr Val Arg Gly Thr Glu Gly Gly Gly Ile Gly Thr Ser Phe Glu 
        35                  40                  45              

Gln Val Asp Arg Val Val Ser Glu Asn Pro Ala Asp Thr Leu Leu Ala 
    50                  55                  60                  

Phe Phe Asp Leu Gly Ser Ala Lys Met Asn Leu Lys Met Val Thr Asp 
65                  70                  75                  80  

Phe Ser Asp Lys Ser Ile Ile Ile Asn Arg Val Pro Ile Val Glu Gly 
                85                  90                  95      

Ala Tyr Asn Ala Ala Ala Leu Leu Gln Ala Gly Ala Glu Leu Ser Val 
            100                 105                 110         

Ile Gln Thr Gln Leu Ala Glu Leu Glu Ile Asn Lys 
        115                 120                 

<210>   2345
<211>   2457
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2345
atgaaaatta ataaaaaata tctagcaggt tcagtggcag tccttgccct aagtgtttgt   60
tcctatgagc ttggacgtta ccaagctggt caggataaga aagagtctaa tcgagttgct   120
tatatagatg gtgatcaggc tggtcaaaag gcagaaaact tgacaccaga tgaagtcagt   180
aagagggagg ggatcaacgc cgaacaaatt gttatcaaga ttacggatca aggttatgtg   240
acctctcatg gagaccatta tcattactat aatggcaagg ttccttatga tgccatcatc   300
agtgaagagc tcctcatgaa agatccgaat tatcagttga aggattcaga cattgtcaat   360
gaaatcaagg gtggttatgt cattaaggta aacggtaaat actatgttta ccttaaggat   420
gcagctcatg cggataatat tcggacaaaa gaagagatta aacgtcagaa gcaggaacgc   480
agtcataatc ataactcaag agcagataat gctgttgctg cagccagagc ccaaggacgt   540
tatacaacgg atgatgggta tatcttcaat gcatctgata tcattgagga cacgggtgat   600
gcttatatcg ttcctcacgg cgaccattac cattacattc ctaagaatga gttatcagct   660
agcgagttag ctgctgcaga agcctattgg aatgggaagc agggatctcg tccttcttca   720
agttctagtt ataatgcaaa tccagctcaa ccaagattgt cagagaacca caatctgact   780
gtcactccaa cttatcatca aaatcaaggg gaaaacattt caagcctttt acgtgaattg   840
tatgctaaac ccttatcaga acgccatgtg gaatctgatg gccttatttt cgacccagcg   900
caaatcacaa gtcgaaccgc cagaggtgta gctgtccctc atggtaacca ttaccacttt   960
atcccttatg aacaaatgtc tgaattggaa aaacgaattg ctcgtattat tccccttcgt   1020
tatcgttcaa accattgggt accagattca agaccagaag aaccaagtcc acaaccgact   1080
ccagaaccta gtccaagtcc gcaaccagct ccaagcaatc caattgatga gaaattggtc   1140
aaagaagctg ttcgaaaagt aggcgatggt tatgtctttg aggagaatgg agtttctcgt   1200
tatatcccag ccaaggatct ttcagcagaa acagcagcag gcattgatag caaactggcc   1260
aagcaggaaa gtttatctca taagctagga actaagaaaa ctgacctccc atctagtgat   1320
cgagaatttt acaataaggc ttatgactta ctagcaagaa ttcaccaaga tttacttgat   1380
aataaaggtc gacaagttga ttttgaggct ttggataacc tgttggaacg actcaaggat   1440
gtctcaagtg ataaagtcaa gttagtggaa gatattcttg ccttcttagc tccgattcgt   1500
catccagaac gtttaggaaa accaaatgcg caaattacct acactgatga tgagattcaa   1560
gtagccaagt tggcaggcaa gtacacaaca gaagacggtt atatctttga tcctcgtgat   1620
ataaccagtg atgaggggga tgcctatgta actccacata tgacccatag ccactggatt   1680
aaaaaagata gtttgtctga agctgagaga gcggcagccc aggcttatgc taaagagaaa   1740
ggtttgaccc ctccttcgac agaccatcag gattcaggaa atactgaggc aaaaggagca   1800
gaagctatct acaaccgcgt gaaagcagct aagaaggtgc cacttgatcg tatgccttac   1860
aatcttcaat atactgtaga agtcaaaaac ggtagtttaa tcatacctca ttatgaccat   1920
taccataaca tcaaatttga gtggtttgac gaaggccttt atgaggcacc taaggggtat   1980
actcttgagg atcttttggc gactgtcaag tactatgtcg aacatccaaa cgaacgtccg   2040
cattcagata atggttttgg taacgctagc gaccatgttc aaagaaacaa aaatggtcaa   2100
gctgatacca atcaaacgga aaaaccaagc gaggagaaac ctcagacaga aaaacctgag   2160
gaagaaaccc ctcgagaaga gaaaccgcaa agcgagaaac cagagtctcc aaaaccaaca   2220
gaggaaccag aagaatcacc agaggaatca gaagaacctc aggtcgagac tgaaaaggtt   2280
gaagaaaaac tgagagaggc tgaagattta cttggaaaaa tccaggatcc aattatcaag   2340
tccaatgcca aagagactct cacaggatta aaaaataatt tactatttgg cacccaggac   2400
aacaatacta ttatggcaga agctgaaaaa ctattggctt tattaaagga gagtaag      2457

<210>   2346
<211>   819
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein (Pneumococcal histidine)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902951 (0.E+01)

<400>   2346
Met Lys Ile Asn Lys Lys Tyr Leu Ala Gly Ser Val Ala Val Leu Ala 
1               5                   10                  15      

Leu Ser Val Cys Ser Tyr Glu Leu Gly Arg Tyr Gln Ala Gly Gln Asp 
            20                  25                  30          

Lys Lys Glu Ser Asn Arg Val Ala Tyr Ile Asp Gly Asp Gln Ala Gly 

        35                  40                  45              

Gln Lys Ala Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu Gly 
    50                  55                  60                  

Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr Val 
65                  70                  75                  80  

Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro Tyr 
                85                  90                  95      

Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr Gln 
            100                 105                 110         

Leu Lys Asp Ser Asp Ile Val Asn Glu Ile Lys Gly Gly Tyr Val Ile 
        115                 120                 125             

Lys Val Asn Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His Ala 
    130                 135                 140                 

Asp Asn Ile Arg Thr Lys Glu Glu Ile Lys Arg Gln Lys Gln Glu Arg 
145                 150                 155                 160 

Ser His Asn His Asn Ser Arg Ala Asp Asn Ala Val Ala Ala Ala Arg 
                165                 170                 175     

Ala Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile Phe Asn Ala Ser 
            180                 185                 190         

Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val Pro His Gly Asp 
        195                 200                 205             

His Tyr His Tyr Ile Pro Lys Asn Glu Leu Ser Ala Ser Glu Leu Ala 
    210                 215                 220                 

Ala Ala Glu Ala Tyr Trp Asn Gly Lys Gln Gly Ser Arg Pro Ser Ser 
225                 230                 235                 240 

Ser Ser Ser Tyr Asn Ala Asn Pro Ala Gln Pro Arg Leu Ser Glu Asn 
                245                 250                 255     

His Asn Leu Thr Val Thr Pro Thr Tyr His Gln Asn Gln Gly Glu Asn 
            260                 265                 270         

Ile Ser Ser Leu Leu Arg Glu Leu Tyr Ala Lys Pro Leu Ser Glu Arg 
        275                 280                 285             

His Val Glu Ser Asp Gly Leu Ile Phe Asp Pro Ala Gln Ile Thr Ser 
    290                 295                 300                 

Arg Thr Ala Arg Gly Val Ala Val Pro His Gly Asn His Tyr His Phe 
305                 310                 315                 320 

Ile Pro Tyr Glu Gln Met Ser Glu Leu Glu Lys Arg Ile Ala Arg Ile 
                325                 330                 335     

Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro 
            340                 345                 350         

Glu Glu Pro Ser Pro Gln Pro Thr Pro Glu Pro Ser Pro Ser Pro Gln 
        355                 360                 365             

Pro Ala Pro Ser Asn Pro Ile Asp Glu Lys Leu Val Lys Glu Ala Val 
    370                 375                 380                 

Arg Lys Val Gly Asp Gly Tyr Val Phe Glu Glu Asn Gly Val Ser Arg 
385                 390                 395                 400 

Tyr Ile Pro Ala Lys Asp Leu Ser Ala Glu Thr Ala Ala Gly Ile Asp 
                405                 410                 415     

Ser Lys Leu Ala Lys Gln Glu Ser Leu Ser His Lys Leu Gly Thr Lys 
            420                 425                 430         

Lys Thr Asp Leu Pro Ser Ser Asp Arg Glu Phe Tyr Asn Lys Ala Tyr 
        435                 440                 445             

Asp Leu Leu Ala Arg Ile His Gln Asp Leu Leu Asp Asn Lys Gly Arg 
    450                 455                 460                 

Gln Val Asp Phe Glu Ala Leu Asp Asn Leu Leu Glu Arg Leu Lys Asp 
465                 470                 475                 480 

Val Ser Ser Asp Lys Val Lys Leu Val Glu Asp Ile Leu Ala Phe Leu 
                485                 490                 495     

Ala Pro Ile Arg His Pro Glu Arg Leu Gly Lys Pro Asn Ala Gln Ile 
            500                 505                 510         

Thr Tyr Thr Asp Asp Glu Ile Gln Val Ala Lys Leu Ala Gly Lys Tyr 
        515                 520                 525             

Thr Thr Glu Asp Gly Tyr Ile Phe Asp Pro Arg Asp Ile Thr Ser Asp 
    530                 535                 540                 

Glu Gly Asp Ala Tyr Val Thr Pro His Met Thr His Ser His Trp Ile 
545                 550                 555                 560 

Lys Lys Asp Ser Leu Ser Glu Ala Glu Arg Ala Ala Ala Gln Ala Tyr 
                565                 570                 575     

Ala Lys Glu Lys Gly Leu Thr Pro Pro Ser Thr Asp His Gln Asp Ser 
            580                 585                 590         

Gly Asn Thr Glu Ala Lys Gly Ala Glu Ala Ile Tyr Asn Arg Val Lys 
        595                 600                 605             

Ala Ala Lys Lys Val Pro Leu Asp Arg Met Pro Tyr Asn Leu Gln Tyr 
    610                 615                 620                 

Thr Val Glu Val Lys Asn Gly Ser Leu Ile Ile Pro His Tyr Asp His 
625                 630                 635                 640 

Tyr His Asn Ile Lys Phe Glu Trp Phe Asp Glu Gly Leu Tyr Glu Ala 
                645                 650                 655     

Pro Lys Gly Tyr Thr Leu Glu Asp Leu Leu Ala Thr Val Lys Tyr Tyr 
            660                 665                 670         

Val Glu His Pro Asn Glu Arg Pro His Ser Asp Asn Gly Phe Gly Asn 
        675                 680                 685             

Ala Ser Asp His Val Gln Arg Asn Lys Asn Gly Gln Ala Asp Thr Asn 
    690                 695                 700                 

Gln Thr Glu Lys Pro Ser Glu Glu Lys Pro Gln Thr Glu Lys Pro Glu 
705                 710                 715                 720 

Glu Glu Thr Pro Arg Glu Glu Lys Pro Gln Ser Glu Lys Pro Glu Ser 
                725                 730                 735     

Pro Lys Pro Thr Glu Glu Pro Glu Glu Ser Pro Glu Glu Ser Glu Glu 
            740                 745                 750         

Pro Gln Val Glu Thr Glu Lys Val Glu Glu Lys Leu Arg Glu Ala Glu 
        755                 760                 765             

Asp Leu Leu Gly Lys Ile Gln Asp Pro Ile Ile Lys Ser Asn Ala Lys 
    770                 775                 780                 

Glu Thr Leu Thr Gly Leu Lys Asn Asn Leu Leu Phe Gly Thr Gln Asp 
785                 790                 795                 800 

Asn Asn Thr Ile Met Ala Glu Ala Glu Lys Leu Leu Ala Leu Leu Lys 
                805                 810                 815     

Glu Ser Lys 
            

<210>   2347
<211>   2406
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2347
ttgattttaa gtgtttgttc ttacgagttg ggactgtatc aagctagaac ggttaaggaa   60
aataatcgtg tttcctatat agatggaaaa caagcgacgc aaaaaacgga gaatttgact   120
cctgatgagg ttagcaagcg tgaaggaatc aatgctgagc aaatcgtcat caagataaca   180
gaccaaggct atgtcacttc acatggcgac cactatcatt attacaatgg taaggttcct   240
tatgacgcta tcatcagtga agaattactc atgaaagatc caaactataa gctaaaagat   300
gaggatattg ttaatgaggt caagggtgga tatgttatca aggtagatgg aaaatactat   360
gtttacctta aggatgctgc ccacgcggat aacgtccgta caaaagagga aatcaatcga   420
caaaaacaag agcatagtca acatcgtgaa ggtggaactc caagaaacga tggtgctgtt   480
gccttggcac gttcgcaagg acgctatact acagatgatg gttatatctt taatgcttct   540
gatatcatag aggatactgg tgatgcttat atcgttcctc atggagatca ttaccattac   600
attcctaaga atgagttatc agctagcgag ttggctgctg cagaagcctt cctatctggt   660
cgaggaaatc tgtcaaattc aagaacctat cgccgacaaa atagcgataa cacttcaaga   720
acaaactggg taccttctgt aagcaatcca ggaactacaa atactaacac aagcaacaac   780
agcaacacta acagtcaagc aagtcaaagt aatgacattg atagtctctt gaaacagctc   840
tacaaactgc ctttgagtca acgacatgta gaatctgatg gccttgtctt tgatccagca   900
caaatcacaa gtcgaacagc tagaggtgtt gcagtgccac acggagatca ttaccacttc   960
atcccttact ctcaaatgtc tgaattggaa gaacgaatcg ctcgtattat tccccttcgt   1020
tatcgttcaa accattgggt accagattca aggccagaac aaccaagtcc acaaccgact   1080
ccggaaccta gtccaggccc gcaacctgca ccaaatctta aaatagactc aaattcttct   1140
ttggttagtc agctggtacg aaaagttggg gaaggatatg tattcgaaga aaagggcatc   1200
tctcgttatg tctttgcgaa agatttacca tctgaaactg ttaaaaatct tgaaagcaag   1260
ttatcaaaac aagagagtgt ttcacacact ttaactgcta aaaaagaaaa tgttgctcct   1320
cgtgaccaag aattttatga taaagcatat aatctgttaa ctgaggctca taaagccttg   1380
tttgaaaata agggtcgtaa ttctgatttc caagccttag acaaattatt agaacgcttg   1440
aatgatgaat cgactaataa agaaaaattg gtagatgatt tattggcatt cctagcacca   1500
attacccatc cagagcgact tggcaaacca aattctcaaa ttgagtatac tgaagacgaa   1560
gttcgtattg ctcaattagc tgataagtat acaacgtcag atggttacat ttttgatgaa   1620
catgatataa tcagtgatga aggagatgca tatgtaacgc ctcatatggg ccatagtcac   1680
tggattggaa aagatagcct ttctgataag gaaaaagttg cagctcaagc ctatactaaa   1740
gaaaaaggta tcctacctcc atctccagac gcagatgtta aagcaaatcc aactggagat   1800
agtgcagcag ctatttacaa tcgtgtgaaa ggggaaaaac gaattccact cgttcgactt   1860
ccatatatgg ttgagcatac agttgaggtt aaaaacggta atttgattat tcctcataag   1920
gatcattacc ataatattaa atttgcttgg tttgatgatc acacatacaa agctccaaat   1980
ggctatacct tggaagattt gtttgcgacg attaagtact acgtagaaca ccctgacgaa   2040
cgtccacatt ctaatgatgg atggggcaat gccagtgagc atgtgttagg caagaaagac   2100
cacagtgaag atccaaataa gaacttcaaa gcggatgaag agccagtaga ggaaacacct   2160
gctgagccag aagtccctca agtagagact gaaaaagtag aagcccaact caaagaagca   2220
gaagttttgc ttgcgaaagt aacggattct agtctgaaag ccaatgcaac agaaactcta   2280
gctggtttac gaaataattt gactcttcaa attatggata acaatagtat catggcagaa   2340
gcagaaaaat tacttgcgtt gttaaaagga agtaatcctt catctgtaag taaggaaaaa   2400
ataaac                                                              2406

<210>   2348
<211>   802
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein (Pneumococcal histidine)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903105 (0.E+01)

<400>   2348
Met Ile Leu Ser Val Cys Ser Tyr Glu Leu Gly Leu Tyr Gln Ala Arg 
1               5                   10                  15      

Thr Val Lys Glu Asn Asn Arg Val Ser Tyr Ile Asp Gly Lys Gln Ala 
            20                  25                  30          

Thr Gln Lys Thr Glu Asn Leu Thr Pro Asp Glu Val Ser Lys Arg Glu 
        35                  40                  45              

Gly Ile Asn Ala Glu Gln Ile Val Ile Lys Ile Thr Asp Gln Gly Tyr 
    50                  55                  60                  

Val Thr Ser His Gly Asp His Tyr His Tyr Tyr Asn Gly Lys Val Pro 
65                  70                  75                  80  

Tyr Asp Ala Ile Ile Ser Glu Glu Leu Leu Met Lys Asp Pro Asn Tyr 
                85                  90                  95      

Lys Leu Lys Asp Glu Asp Ile Val Asn Glu Val Lys Gly Gly Tyr Val 
            100                 105                 110         

Ile Lys Val Asp Gly Lys Tyr Tyr Val Tyr Leu Lys Asp Ala Ala His 
        115                 120                 125             

Ala Asp Asn Val Arg Thr Lys Glu Glu Ile Asn Arg Gln Lys Gln Glu 
    130                 135                 140                 

His Ser Gln His Arg Glu Gly Gly Thr Pro Arg Asn Asp Gly Ala Val 
145                 150                 155                 160 

Ala Leu Ala Arg Ser Gln Gly Arg Tyr Thr Thr Asp Asp Gly Tyr Ile 
                165                 170                 175     

Phe Asn Ala Ser Asp Ile Ile Glu Asp Thr Gly Asp Ala Tyr Ile Val 
            180                 185                 190         

Pro His Gly Asp His Tyr His Tyr Ile Pro Lys Asn Glu Leu Ser Ala 
        195                 200                 205             

Ser Glu Leu Ala Ala Ala Glu Ala Phe Leu Ser Gly Arg Gly Asn Leu 
    210                 215                 220                 

Ser Asn Ser Arg Thr Tyr Arg Arg Gln Asn Ser Asp Asn Thr Ser Arg 
225                 230                 235                 240 

Thr Asn Trp Val Pro Ser Val Ser Asn Pro Gly Thr Thr Asn Thr Asn 
                245                 250                 255     

Thr Ser Asn Asn Ser Asn Thr Asn Ser Gln Ala Ser Gln Ser Asn Asp 
            260                 265                 270         

Ile Asp Ser Leu Leu Lys Gln Leu Tyr Lys Leu Pro Leu Ser Gln Arg 
        275                 280                 285             

His Val Glu Ser Asp Gly Leu Val Phe Asp Pro Ala Gln Ile Thr Ser 
    290                 295                 300                 

Arg Thr Ala Arg Gly Val Ala Val Pro His Gly Asp His Tyr His Phe 
305                 310                 315                 320 

Ile Pro Tyr Ser Gln Met Ser Glu Leu Glu Glu Arg Ile Ala Arg Ile 
                325                 330                 335     

Ile Pro Leu Arg Tyr Arg Ser Asn His Trp Val Pro Asp Ser Arg Pro 
            340                 345                 350         

Glu Gln Pro Ser Pro Gln Pro Thr Pro Glu Pro Ser Pro Gly Pro Gln 
        355                 360                 365             

Pro Ala Pro Asn Leu Lys Ile Asp Ser Asn Ser Ser Leu Val Ser Gln 
    370                 375                 380                 

Leu Val Arg Lys Val Gly Glu Gly Tyr Val Phe Glu Glu Lys Gly Ile 
385                 390                 395                 400 

Ser Arg Tyr Val Phe Ala Lys Asp Leu Pro Ser Glu Thr Val Lys Asn 
                405                 410                 415     

Leu Glu Ser Lys Leu Ser Lys Gln Glu Ser Val Ser His Thr Leu Thr 
            420                 425                 430         

Ala Lys Lys Glu Asn Val Ala Pro Arg Asp Gln Glu Phe Tyr Asp Lys 
        435                 440                 445             

Ala Tyr Asn Leu Leu Thr Glu Ala His Lys Ala Leu Phe Glu Asn Lys 
    450                 455                 460                 

Gly Arg Asn Ser Asp Phe Gln Ala Leu Asp Lys Leu Leu Glu Arg Leu 
465                 470                 475                 480 

Asn Asp Glu Ser Thr Asn Lys Glu Lys Leu Val Asp Asp Leu Leu Ala 
                485                 490                 495     

Phe Leu Ala Pro Ile Thr His Pro Glu Arg Leu Gly Lys Pro Asn Ser 
            500                 505                 510         

Gln Ile Glu Tyr Thr Glu Asp Glu Val Arg Ile Ala Gln Leu Ala Asp 
        515                 520                 525             

Lys Tyr Thr Thr Ser Asp Gly Tyr Ile Phe Asp Glu His Asp Ile Ile 
    530                 535                 540                 

Ser Asp Glu Gly Asp Ala Tyr Val Thr Pro His Met Gly His Ser His 
545                 550                 555                 560 

Trp Ile Gly Lys Asp Ser Leu Ser Asp Lys Glu Lys Val Ala Ala Gln 
                565                 570                 575     

Ala Tyr Thr Lys Glu Lys Gly Ile Leu Pro Pro Ser Pro Asp Ala Asp 
            580                 585                 590         

Val Lys Ala Asn Pro Thr Gly Asp Ser Ala Ala Ala Ile Tyr Asn Arg 
        595                 600                 605             

Val Lys Gly Glu Lys Arg Ile Pro Leu Val Arg Leu Pro Tyr Met Val 
    610                 615                 620                 

Glu His Thr Val Glu Val Lys Asn Gly Asn Leu Ile Ile Pro His Lys 
625                 630                 635                 640 

Asp His Tyr His Asn Ile Lys Phe Ala Trp Phe Asp Asp His Thr Tyr 
                645                 650                 655     

Lys Ala Pro Asn Gly Tyr Thr Leu Glu Asp Leu Phe Ala Thr Ile Lys 
            660                 665                 670         

Tyr Tyr Val Glu His Pro Asp Glu Arg Pro His Ser Asn Asp Gly Trp 
        675                 680                 685             

Gly Asn Ala Ser Glu His Val Leu Gly Lys Lys Asp His Ser Glu Asp 
    690                 695                 700                 

Pro Asn Lys Asn Phe Lys Ala Asp Glu Glu Pro Val Glu Glu Thr Pro 
705                 710                 715                 720 

Ala Glu Pro Glu Val Pro Gln Val Glu Thr Glu Lys Val Glu Ala Gln 
                725                 730                 735     

Leu Lys Glu Ala Glu Val Leu Leu Ala Lys Val Thr Asp Ser Ser Leu 
            740                 745                 750         

Lys Ala Asn Ala Thr Glu Thr Leu Ala Gly Leu Arg Asn Asn Leu Thr 
        755                 760                 765             

Leu Gln Ile Met Asp Asn Asn Ser Ile Met Ala Glu Ala Glu Lys Leu 
    770                 775                 780                 

Leu Ala Leu Leu Lys Gly Ser Asn Pro Ser Ser Val Ser Lys Glu Lys 
785                 790                 795                 800 

Ile Asn 
        

<210>   2349
<211>   1260
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2349
gtgattgtga ttgcgcatga cttgactcct tcagatacag ctcaattgga caaaaacttt   60
gtaaaagctt ttgtaaccaa cattggtgga cgtacaagcc actcagctat catggcacgt   120
acacttgaaa ttgctgctgt attaggtaca aataacatca ctgaaatcgt taaagacggt   180
gacatccttg ctgttaacgg gatcactgga gaagtgatta tcaacccaac agatgaacaa   240
gcggcagaat ttaaagcagc tggtgaagcc tatgcgaaac aaaaagctga atgggcactt   300
ttgaaagatg ctcaaacagt gactgctgac ggtaaacact tcgagttggc tgctaatatc   360
ggtactccaa aagacgttga aggtgttaac aacaacggtg cagaagctgt tggactttac   420
cgtacagagt tcttgtacat ggattctcaa gacttcccaa ctgaagatga gcagtatgaa   480
gcatacaagg ctgttcttga aggaatgaac ggtaaacctg ttgtcgttcg tacaatggat   540
atcggtggag ataaggaact tccttacttc gatatgcctc acgaaatgaa cccattcctt   600
ggattccgtg ctcttcgtat ctctatctct gagactggag atgctatgtt ccgcacacaa   660
atccgtgctc ttcttcgtgc gtctgttcac ggtcaattgc gtatcatgtt cccaatggtt   720
gcgctcttga aagaattccg tgcagcgaaa gcagtctttg atgaagaaaa agcaaacctt   780
cttgctgaag gtgttgcagt tgcggataac atccaagttg gtatcatgat cgagattcct   840
gcagcggcta tgcttgcaga ccaatttgct aaagaagttg acttcttctc aattggtaca   900
aacgacttga tccaatatac aatggcagca gaccgtatga acgaacaagt ttcatacctt   960
taccaaccat acaacccatc aatcctacgc ttgattaaca atgtgatcaa agcagctcac   1020
gctgaaggta aatgggctgg tatgtgtggt gagatggctg gtgaccaaca agctgttcca   1080
cttcttgtcg gaatgggctt ggatgagttc tctatgtcag caacatctgt acttcgtaca   1140
cgcagcttga tgaagaaact cgacacagct aagatggaag agtacgcaaa ccgtgccctt   1200
acagaatgct caacaatgga agaagttctt gaacttcaaa aagaatacgt taattttgat   1260

<210>   2350
<211>   420
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoenolpyruvate-protein phosphotransferase

<400>   2350
Met Ile Val Ile Ala His Asp Leu Thr Pro Ser Asp Thr Ala Gln Leu 
1               5                   10                  15      

Asp Lys Asn Phe Val Lys Ala Phe Val Thr Asn Ile Gly Gly Arg Thr 
            20                  25                  30          

Ser His Ser Ala Ile Met Ala Arg Thr Leu Glu Ile Ala Ala Val Leu 
        35                  40                  45              

Gly Thr Asn Asn Ile Thr Glu Ile Val Lys Asp Gly Asp Ile Leu Ala 
    50                  55                  60                  

Val Asn Gly Ile Thr Gly Glu Val Ile Ile Asn Pro Thr Asp Glu Gln 
65                  70                  75                  80  

Ala Ala Glu Phe Lys Ala Ala Gly Glu Ala Tyr Ala Lys Gln Lys Ala 
                85                  90                  95      

Glu Trp Ala Leu Leu Lys Asp Ala Gln Thr Val Thr Ala Asp Gly Lys 
            100                 105                 110         

His Phe Glu Leu Ala Ala Asn Ile Gly Thr Pro Lys Asp Val Glu Gly 
        115                 120                 125             

Val Asn Asn Asn Gly Ala Glu Ala Val Gly Leu Tyr Arg Thr Glu Phe 
    130                 135                 140                 

Leu Tyr Met Asp Ser Gln Asp Phe Pro Thr Glu Asp Glu Gln Tyr Glu 
145                 150                 155                 160 

Ala Tyr Lys Ala Val Leu Glu Gly Met Asn Gly Lys Pro Val Val Val 
                165                 170                 175     

Arg Thr Met Asp Ile Gly Gly Asp Lys Glu Leu Pro Tyr Phe Asp Met 
            180                 185                 190         

Pro His Glu Met Asn Pro Phe Leu Gly Phe Arg Ala Leu Arg Ile Ser 
        195                 200                 205             

Ile Ser Glu Thr Gly Asp Ala Met Phe Arg Thr Gln Ile Arg Ala Leu 
    210                 215                 220                 

Leu Arg Ala Ser Val His Gly Gln Leu Arg Ile Met Phe Pro Met Val 
225                 230                 235                 240 

Ala Leu Leu Lys Glu Phe Arg Ala Ala Lys Ala Val Phe Asp Glu Glu 
                245                 250                 255     

Lys Ala Asn Leu Leu Ala Glu Gly Val Ala Val Ala Asp Asn Ile Gln 
            260                 265                 270         

Val Gly Ile Met Ile Glu Ile Pro Ala Ala Ala Met Leu Ala Asp Gln 
        275                 280                 285             

Phe Ala Lys Glu Val Asp Phe Phe Ser Ile Gly Thr Asn Asp Leu Ile 
    290                 295                 300                 

Gln Tyr Thr Met Ala Ala Asp Arg Met Asn Glu Gln Val Ser Tyr Leu 
305                 310                 315                 320 

Tyr Gln Pro Tyr Asn Pro Ser Ile Leu Arg Leu Ile Asn Asn Val Ile 
                325                 330                 335     

Lys Ala Ala His Ala Glu Gly Lys Trp Ala Gly Met Cys Gly Glu Met 
            340                 345                 350         

Ala Gly Asp Gln Gln Ala Val Pro Leu Leu Val Gly Met Gly Leu Asp 
        355                 360                 365             

Glu Phe Ser Met Ser Ala Thr Ser Val Leu Arg Thr Arg Ser Leu Met 
    370                 375                 380                 

Lys Lys Leu Asp Thr Ala Lys Met Glu Glu Tyr Ala Asn Arg Ala Leu 
385                 390                 395                 400 

Thr Glu Cys Ser Thr Met Glu Glu Val Leu Glu Leu Gln Lys Glu Tyr 
                405                 410                 415     

Val Asn Phe Asp 
            420 

<210>   2351
<211>   402
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2351
atgacagaaa tgcttaaagg aatcgcagca tctgacggtg ttgcagttgc aaaagcatat   60
ctactcgttc agccggattt gtcatttgag actattacag tcgaagatac aaacgcagaa   120
gaagctcgcc ttgatgccgc tctacaggca tcacaagacg agctttctgt tattcgcgag   180
aaagcagtag gtacgctcgg tgaagaagca gctcaagttt ttgatgctca cttaatggtt   240
cttgctgacc cagaaatgat cagccaaatc aaggaaacta tccgtgcgaa gaaagtgaat   300
gcagaagcag gtctgaaaga agttacagat atgtttatca ctatctttga aggcatggaa   360
gacaacccat acatgcaaga acgcgcagcg atatccgcga cg                      402

<210>   2352
<211>   134
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoenolpyruvate-protein phosphotransferase FRAMESHIFT (ptsI)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903106 (0.E+01)

<400>   2352
Met Thr Glu Met Leu Lys Gly Ile Ala Ala Ser Asp Gly Val Ala Val 
1               5                   10                  15      

Ala Lys Ala Tyr Leu Leu Val Gln Pro Asp Leu Ser Phe Glu Thr Ile 
            20                  25                  30          

Thr Val Glu Asp Thr Asn Ala Glu Glu Ala Arg Leu Asp Ala Ala Leu 
        35                  40                  45              

Gln Ala Ser Gln Asp Glu Leu Ser Val Ile Arg Glu Lys Ala Val Gly 
    50                  55                  60                  

Thr Leu Gly Glu Glu Ala Ala Gln Val Phe Asp Ala His Leu Met Val 
65                  70                  75                  80  

Leu Ala Asp Pro Glu Met Ile Ser Gln Ile Lys Glu Thr Ile Arg Ala 
                85                  90                  95      

Lys Lys Val Asn Ala Glu Ala Gly Leu Lys Glu Val Thr Asp Met Phe 
            100                 105                 110         

Ile Thr Ile Phe Glu Gly Met Glu Asp Asn Pro Tyr Met Gln Glu Arg 
        115                 120                 125             

Ala Ala Ile Ser Ala Thr 
    130                 

<210>   2353
<211>   261
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2353
atggcttcta aagatttcca cgtagtggca gaaacaggta ttcacgcacg tccagcaaca   60
ttgttggtac aaactgctag caaatttgct tcagatatca ctcttgagta caaaggtaaa   120
tcagttaacc ttaaatcaat tatgggtgtt atgagtcttg gtgttggcca aggtgctgac   180
gtaactatct cagctgaagg tgcagatgca gatgacgcta tcgctgcaat ctcagaaaca   240
atggaaaaag aaggattggc a                                             261

<210>   2354
<211>   87
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphocarrier protein HPr (ptsH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903107 (1.E-43)

<400>   2354
Met Ala Ser Lys Asp Phe His Val Val Ala Glu Thr Gly Ile His Ala 
1               5                   10                  15      

Arg Pro Ala Thr Leu Leu Val Gln Thr Ala Ser Lys Phe Ala Ser Asp 
            20                  25                  30          

Ile Thr Leu Glu Tyr Lys Gly Lys Ser Val Asn Leu Lys Ser Ile Met 
        35                  40                  45              

Gly Val Met Ser Leu Gly Val Gly Gln Gly Ala Asp Val Thr Ile Ser 
    50                  55                  60                  

Ala Glu Gly Ala Asp Ala Asp Asp Ala Ile Ala Ala Ile Ser Glu Thr 
65                  70                  75                  80  

Met Glu Lys Glu Gly Leu Ala 
                85          

<210>   2355
<211>   234
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2355
ttgaagagga gttacacaat ggtaaccgtt tattctaaaa acaattgtgt ccaatgtaaa   60
atgaccaagc gtttcttgga cagtaataat gtctcttatc gtgaaatcaa tcttgatgag   120
caacctgagt acgtcgatca agttaaagag ctcggtttta gcgcagctcc tgttatccaa   180
acaccaactg aagtcttttc aggtttccaa ccaggaaaac tgaaacaatt agca         234

<210>   2356
<211>   78
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   NrdH-redoxin (nrdH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903108 (3.E-38)

<400>   2356
Met Lys Arg Ser Tyr Thr Met Val Thr Val Tyr Ser Lys Asn Asn Cys 
1               5                   10                  15      

Val Gln Cys Lys Met Thr Lys Arg Phe Leu Asp Ser Asn Asn Val Ser 
            20                  25                  30          

Tyr Arg Glu Ile Asn Leu Asp Glu Gln Pro Glu Tyr Val Asp Gln Val 
        35                  40                  45              

Lys Glu Leu Gly Phe Ser Ala Ala Pro Val Ile Gln Thr Pro Thr Glu 
    50                  55                  60                  

Val Phe Ser Gly Phe Gln Pro Gly Lys Leu Lys Gln Leu Ala 
65                  70                  75              

<210>   2357
<211>   2157
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2357
atgggattaa aacatcttga agacgtgact tacttccgtc ttaataacga aattaaccgt   60
cctgttaatg gacaaatcat gcttcataaa gacaaggaag ccttggatgc tttctttaaa   120
gaaaatgtag ttccaaacac tatggttttt gattcaatca aagacaaaat caattacctc   180
attgaacaca actacatcga aacagccttt atcaagaaat accgtccaga gttcttggaa   240
gaattagctc aatttatcaa agaccaaaac ttccaattca agtcattcat ggcagcttat   300
aaattttaca atcaatatgc cttaaagact aatgacggtg aatactatct tgaaaatatg   360
gaagaccgtg tcttcttcaa tgccctttat ttcgctgatg ggaatgaagc tgttgcaatc   420
gatattgcca atgaaatcat ccaccaacgc taccaacctg ctactccttc cttcttgaat   480
gctggacgtg ctcgtcgtgg ggagttggta tcttgtttcc taatccaagt gacggatgat   540
atgaactcta tcgggcgttc tatcaactca gctcttcaac tttcacgtat tggtggtggt   600
gtgggaatta ccctcagcaa ccttcgtgaa gctggtgcac ctatcaaagg ctatgaagga   660
gctgcttcag gtgtcgttcc tgttatgaag ctttttgaag acagcttctc ttactccaac   720
caattggggc aacgtcaagg tgctggtgtt gtctacctca acgtctttca cccagatatc   780
atcgctttcc tttcaactaa gaaagaaaac gctgatgaaa aagtacgtgt caagactcta   840
tcacttggtg ttgtagtacc tgataaattc tacgaattgg ctcgtaaaaa tgaagaaatg   900
tacctcttca gcccttactc tgtagaaaaa gaatacggtg tgccattcaa ttacatcgac   960
attactgaaa aatacgatga attggtcgca aatccaaata ttcgcaagac aaaaatcaag   1020
gcgcgggatt tggaaactga aatctctaaa ttgcaacaag agtctggcta tccttatgta   1080
gtcaacatcg atacggctaa ccgtgcaaat cctgttgatg gaaagattat catgagtaac   1140
ttgtgttctg agattcttca agttcaagaa ccaagcttga tcaacgatgc tcaagaattc   1200
cttcaaatgg gaacagatgt ttcatgtaac ctgggttcaa ccaacgtggt taacatgatg   1260
acttcacctg attttggtcg ttctatccgt gctatggttc gtgcccttac tttcgttaca   1320
gatagttcac atatcgtagc tgtaccaacg attgaccatg gaaatagcca agcccacacc   1380
tttggtctcg gtgccatggg actgcacagc taccttgccc aacaactcat tgaatatggt   1440
tcacctgagt ctgttgaatt tacaagcatc tactttatgc ttatgaacta ctggaccttg   1500
gtagagtcaa acaatattgc acgtgaacgt ggtattacct tccacaactt tgaaaaatca   1560
gactatgcta acggaagtta ctttgacaag tatgtaactg gtgaatttgt tccaacatca   1620
gaccgtgtta aagaactctt caaaaatgtc tttatccctg gtgttgctga ttgggctgaa   1680
cttcgcgaca aggttcaaga agatggtctt taccaccaaa atcgccttgc tgtagcgcca   1740

aatggttcta tcagctatat caacgacgtt tctgcttcta tccacccgat tacgcaacgt   1800
atcgaagaac gccaagagaa gaaaattggt aaaatctatt accctgctgc tggcttgtct   1860
acagaaacca ttccttacta cacttctgcc tacgatatgg atatgcgtaa agtcatcgat   1920
gtttacgctg ctgcgactga acacgtggat caaggacttt cactcaccct cttcatgcgc   1980
agtgacattc caaaaggcct ttacgaatgg aagagggaaa ataaacaaac gacacgtgac   2040
ttgtccatcc ttcgtaacta tgcctttaac aagggaatca agtctatcta ctacgtccgt   2100
acctttacag atgacggtgg agaagtcggc gccaaccaat gtgaaagctg tgtgatt      2157

<210>   2358
<211>   719
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribonucleoside-diphosphate reductase 2, alpha subunit (nrdE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903109 (0.E+01)

<400>   2358
Met Gly Leu Lys His Leu Glu Asp Val Thr Tyr Phe Arg Leu Asn Asn 
1               5                   10                  15      

Glu Ile Asn Arg Pro Val Asn Gly Gln Ile Met Leu His Lys Asp Lys 
            20                  25                  30          

Glu Ala Leu Asp Ala Phe Phe Lys Glu Asn Val Val Pro Asn Thr Met 
        35                  40                  45              

Val Phe Asp Ser Ile Lys Asp Lys Ile Asn Tyr Leu Ile Glu His Asn 
    50                  55                  60                  

Tyr Ile Glu Thr Ala Phe Ile Lys Lys Tyr Arg Pro Glu Phe Leu Glu 
65                  70                  75                  80  

Glu Leu Ala Gln Phe Ile Lys Asp Gln Asn Phe Gln Phe Lys Ser Phe 
                85                  90                  95      

Met Ala Ala Tyr Lys Phe Tyr Asn Gln Tyr Ala Leu Lys Thr Asn Asp 
            100                 105                 110         

Gly Glu Tyr Tyr Leu Glu Asn Met Glu Asp Arg Val Phe Phe Asn Ala 
        115                 120                 125             

Leu Tyr Phe Ala Asp Gly Asn Glu Ala Val Ala Ile Asp Ile Ala Asn 
    130                 135                 140                 

Glu Ile Ile His Gln Arg Tyr Gln Pro Ala Thr Pro Ser Phe Leu Asn 
145                 150                 155                 160 

Ala Gly Arg Ala Arg Arg Gly Glu Leu Val Ser Cys Phe Leu Ile Gln 
                165                 170                 175     

Val Thr Asp Asp Met Asn Ser Ile Gly Arg Ser Ile Asn Ser Ala Leu 
            180                 185                 190         

Gln Leu Ser Arg Ile Gly Gly Gly Val Gly Ile Thr Leu Ser Asn Leu 
        195                 200                 205             

Arg Glu Ala Gly Ala Pro Ile Lys Gly Tyr Glu Gly Ala Ala Ser Gly 
    210                 215                 220                 

Val Val Pro Val Met Lys Leu Phe Glu Asp Ser Phe Ser Tyr Ser Asn 
225                 230                 235                 240 

Gln Leu Gly Gln Arg Gln Gly Ala Gly Val Val Tyr Leu Asn Val Phe 
                245                 250                 255     

His Pro Asp Ile Ile Ala Phe Leu Ser Thr Lys Lys Glu Asn Ala Asp 
            260                 265                 270         

Glu Lys Val Arg Val Lys Thr Leu Ser Leu Gly Val Val Val Pro Asp 
        275                 280                 285             

Lys Phe Tyr Glu Leu Ala Arg Lys Asn Glu Glu Met Tyr Leu Phe Ser 
    290                 295                 300                 

Pro Tyr Ser Val Glu Lys Glu Tyr Gly Val Pro Phe Asn Tyr Ile Asp 
305                 310                 315                 320 

Ile Thr Glu Lys Tyr Asp Glu Leu Val Ala Asn Pro Asn Ile Arg Lys 
                325                 330                 335     

Thr Lys Ile Lys Ala Arg Asp Leu Glu Thr Glu Ile Ser Lys Leu Gln 
            340                 345                 350         

Gln Glu Ser Gly Tyr Pro Tyr Val Val Asn Ile Asp Thr Ala Asn Arg 
        355                 360                 365             

Ala Asn Pro Val Asp Gly Lys Ile Ile Met Ser Asn Leu Cys Ser Glu 
    370                 375                 380                 

Ile Leu Gln Val Gln Glu Pro Ser Leu Ile Asn Asp Ala Gln Glu Phe 
385                 390                 395                 400 

Leu Gln Met Gly Thr Asp Val Ser Cys Asn Leu Gly Ser Thr Asn Val 
                405                 410                 415     

Val Asn Met Met Thr Ser Pro Asp Phe Gly Arg Ser Ile Arg Ala Met 
            420                 425                 430         

Val Arg Ala Leu Thr Phe Val Thr Asp Ser Ser His Ile Val Ala Val 
        435                 440                 445             

Pro Thr Ile Asp His Gly Asn Ser Gln Ala His Thr Phe Gly Leu Gly 
    450                 455                 460                 

Ala Met Gly Leu His Ser Tyr Leu Ala Gln Gln Leu Ile Glu Tyr Gly 
465                 470                 475                 480 

Ser Pro Glu Ser Val Glu Phe Thr Ser Ile Tyr Phe Met Leu Met Asn 
                485                 490                 495     

Tyr Trp Thr Leu Val Glu Ser Asn Asn Ile Ala Arg Glu Arg Gly Ile 
            500                 505                 510         

Thr Phe His Asn Phe Glu Lys Ser Asp Tyr Ala Asn Gly Ser Tyr Phe 
        515                 520                 525             

Asp Lys Tyr Val Thr Gly Glu Phe Val Pro Thr Ser Asp Arg Val Lys 
    530                 535                 540                 

Glu Leu Phe Lys Asn Val Phe Ile Pro Gly Val Ala Asp Trp Ala Glu 
545                 550                 555                 560 

Leu Arg Asp Lys Val Gln Glu Asp Gly Leu Tyr His Gln Asn Arg Leu 
                565                 570                 575     

Ala Val Ala Pro Asn Gly Ser Ile Ser Tyr Ile Asn Asp Val Ser Ala 
            580                 585                 590         

Ser Ile His Pro Ile Thr Gln Arg Ile Glu Glu Arg Gln Glu Lys Lys 
        595                 600                 605             

Ile Gly Lys Ile Tyr Tyr Pro Ala Ala Gly Leu Ser Thr Glu Thr Ile 
    610                 615                 620                 

Pro Tyr Tyr Thr Ser Ala Tyr Asp Met Asp Met Arg Lys Val Ile Asp 
625                 630                 635                 640 

Val Tyr Ala Ala Ala Thr Glu His Val Asp Gln Gly Leu Ser Leu Thr 
                645                 650                 655     

Leu Phe Met Arg Ser Asp Ile Pro Lys Gly Leu Tyr Glu Trp Lys Arg 
            660                 665                 670         

Glu Asn Lys Gln Thr Thr Arg Asp Leu Ser Ile Leu Arg Asn Tyr Ala 
        675                 680                 685             

Phe Asn Lys Gly Ile Lys Ser Ile Tyr Tyr Val Arg Thr Phe Thr Asp 
    690                 695                 700                 

Asp Gly Gly Glu Val Gly Ala Asn Gln Cys Glu Ser Cys Val Ile 
705                 710                 715                 

<210>   2359
<211>   960
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2359
atggaaactt actacaaagc cattaactgg aatgccatcg aagatgtcat cgacaaatca   60
acttgggaaa aactgacgga gcaattttgg ctcgatacac gtattccctt atcaaacgac   120
ttggatgact ggagaaagct atctaacaaa gagaaagact tggtcggaaa agtttttggt   180
ggtttaaccc ttcttgacac tatgcaatct gaaactgggg ttcaagccct tcgcgcagac   240
atccgtacac cacatgagga agctgtcttc aataacatcc aatttatgga atctgtccac   300
gctaaatctt actcatcaat cttttctacc ttgaatacta aggctgagat tgaagaaatt   360
ttcgaatgga ccaataccaa tccttaccta caaaagaagg ctgagattgt caacgaaatc   420
tacctaaacg gcagcccact tgaaaagaaa gttgccagcg tcttcctcga aaccttcctc   480
ttctactctg gtttcttcac tcccctctac tatctcggta acaacaaact tgccaacgtt   540
gcagaaatca ttaaattgat tattcgtgac gagtctgttc acggaaccta cattggttac   600
aaattccaac ttggtttcaa tgaattacct gaagaagagc aagaaaaact caaagaatgg   660
atgtacgacc tactctatac tctttatgaa aatgaagaag gctacacaga gagtctttat   720
gacggtgttg gttggactga agaggttaaa accttccttc gctacaatgc caataaagct   780
ctcatgaaca tgggacaaga tccacttttc ccagattcag ctgaagatgt caacccaatc   840
gttatgaacg gtatttcaac aggaacttcc aaccatgact tcttctctca agtcggaaat   900
ggttaccttc ttggcgaagt tgaagccatg caagatgatg actacaacta cggtttgcac   960

<210>   2360
<211>   320
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribonucleoside-diphosphate reductase 2, beta subunit (nrdF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903110 (0.E+01)

<400>   2360
Met Glu Thr Tyr Tyr Lys Ala Ile Asn Trp Asn Ala Ile Glu Asp Val 
1               5                   10                  15      

Ile Asp Lys Ser Thr Trp Glu Lys Leu Thr Glu Gln Phe Trp Leu Asp 
            20                  25                  30          

Thr Arg Ile Pro Leu Ser Asn Asp Leu Asp Asp Trp Arg Lys Leu Ser 
        35                  40                  45              

Asn Lys Glu Lys Asp Leu Val Gly Lys Val Phe Gly Gly Leu Thr Leu 
    50                  55                  60                  

Leu Asp Thr Met Gln Ser Glu Thr Gly Val Gln Ala Leu Arg Ala Asp 
65                  70                  75                  80  

Ile Arg Thr Pro His Glu Glu Ala Val Phe Asn Asn Ile Gln Phe Met 
                85                  90                  95      

Glu Ser Val His Ala Lys Ser Tyr Ser Ser Ile Phe Ser Thr Leu Asn 
            100                 105                 110         

Thr Lys Ala Glu Ile Glu Glu Ile Phe Glu Trp Thr Asn Thr Asn Pro 
        115                 120                 125             

Tyr Leu Gln Lys Lys Ala Glu Ile Val Asn Glu Ile Tyr Leu Asn Gly 
    130                 135                 140                 

Ser Pro Leu Glu Lys Lys Val Ala Ser Val Phe Leu Glu Thr Phe Leu 
145                 150                 155                 160 

Phe Tyr Ser Gly Phe Phe Thr Pro Leu Tyr Tyr Leu Gly Asn Asn Lys 
                165                 170                 175     

Leu Ala Asn Val Ala Glu Ile Ile Lys Leu Ile Ile Arg Asp Glu Ser 
            180                 185                 190         

Val His Gly Thr Tyr Ile Gly Tyr Lys Phe Gln Leu Gly Phe Asn Glu 
        195                 200                 205             

Leu Pro Glu Glu Glu Gln Glu Lys Leu Lys Glu Trp Met Tyr Asp Leu 
    210                 215                 220                 

Leu Tyr Thr Leu Tyr Glu Asn Glu Glu Gly Tyr Thr Glu Ser Leu Tyr 
225                 230                 235                 240 

Asp Gly Val Gly Trp Thr Glu Glu Val Lys Thr Phe Leu Arg Tyr Asn 
                245                 250                 255     

Ala Asn Lys Ala Leu Met Asn Met Gly Gln Asp Pro Leu Phe Pro Asp 
            260                 265                 270         

Ser Ala Glu Asp Val Asn Pro Ile Val Met Asn Gly Ile Ser Thr Gly 
        275                 280                 285             

Thr Ser Asn His Asp Phe Phe Ser Gln Val Gly Asn Gly Tyr Leu Leu 
    290                 295                 300                 

Gly Glu Val Glu Ala Met Gln Asp Asp Asp Tyr Asn Tyr Gly Leu His 
305                 310                 315                 320 


<210>   2361
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2361
ttggttaatt tttcttgttt gagcatatta tcacctcgtt tcctactact atcttaccat   60
aaactagctc atcattcaaa tacaaaaaca acaaaa                             96

<210>   2362
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2362
Met Val Asn Phe Ser Cys Leu Ser Ile Leu Ser Pro Arg Phe Leu Leu 
1               5                   10                  15      

Leu Ser Tyr His Lys Leu Ala His His Ser Asn Thr Lys Thr Thr Lys 
            20                  25                  30          


<210>   2363
<211>   759
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2363
atgctcaaac aagaaaaatt aaccaaaatt ttagagatag taaatagtaa aggaaccata   60
acagttaaac agattatgga cgaaatagcc gtttcagata tgactgcaag gcgctattta   120
caggaattag ctgataaaga tttgctgatt cgtgtgcatg gtggagctga aaaacttcga   180
accaactccc ttttgactaa tgagcgatca aatattgaaa aacaagccct ccaaacggca   240
gaaaaacaag aaatagccca ttttgcaggc agtctagtag aagaaagaga aactattttc   300
attggaccag gaacaacatt agagtttttt gcgcgtgagt tgcctattga caatatccgc   360
gtcgtaacca acagtctacc tgtttttctg attttaagcg aacgaaaatt aacagatttg   420
attttaatag gtggaaatta tcgcgatatt acaggtgctt ttgttggtac attgacccta   480
caaaatctct ctaatctcca attttctaaa gctttcgtta gctgtaatgg tattcaaaac   540
ggagctctag ctacttttag cgaggaagag ggagaggctc aacgcatcgc tttaaataat   600
tctaataaaa aatatttact cgcagatcat agcaagttca ataagtttga tttttatact   660
ttttataatg tatcaaatct tgatactatt gtttcagatt ctaaactaag tgattcaatc   720
ctttttaagc tatctaaaca cattaaagtc atcaagcct                          759

<210>   2364
<211>   253
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lactose phosphotransferase system repressor (lacR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903111 (e-138)

<400>   2364
Met Leu Lys Gln Glu Lys Leu Thr Lys Ile Leu Glu Ile Val Asn Ser 
1               5                   10                  15      

Lys Gly Thr Ile Thr Val Lys Gln Ile Met Asp Glu Ile Ala Val Ser 
            20                  25                  30          

Asp Met Thr Ala Arg Arg Tyr Leu Gln Glu Leu Ala Asp Lys Asp Leu 
        35                  40                  45              

Leu Ile Arg Val His Gly Gly Ala Glu Lys Leu Arg Thr Asn Ser Leu 
    50                  55                  60                  

Leu Thr Asn Glu Arg Ser Asn Ile Glu Lys Gln Ala Leu Gln Thr Ala 
65                  70                  75                  80  

Glu Lys Gln Glu Ile Ala His Phe Ala Gly Ser Leu Val Glu Glu Arg 
                85                  90                  95      

Glu Thr Ile Phe Ile Gly Pro Gly Thr Thr Leu Glu Phe Phe Ala Arg 
            100                 105                 110         

Glu Leu Pro Ile Asp Asn Ile Arg Val Val Thr Asn Ser Leu Pro Val 
        115                 120                 125             

Phe Leu Ile Leu Ser Glu Arg Lys Leu Thr Asp Leu Ile Leu Ile Gly 
    130                 135                 140                 

Gly Asn Tyr Arg Asp Ile Thr Gly Ala Phe Val Gly Thr Leu Thr Leu 
145                 150                 155                 160 

Gln Asn Leu Ser Asn Leu Gln Phe Ser Lys Ala Phe Val Ser Cys Asn 
                165                 170                 175     

Gly Ile Gln Asn Gly Ala Leu Ala Thr Phe Ser Glu Glu Glu Gly Glu 
            180                 185                 190         

Ala Gln Arg Ile Ala Leu Asn Asn Ser Asn Lys Lys Tyr Leu Leu Ala 
        195                 200                 205             

Asp His Ser Lys Phe Asn Lys Phe Asp Phe Tyr Thr Phe Tyr Asn Val 
    210                 215                 220                 

Ser Asn Leu Asp Thr Ile Val Ser Asp Ser Lys Leu Ser Asp Ser Ile 
225                 230                 235                 240 

Leu Phe Lys Leu Ser Lys His Ile Lys Val Ile Lys Pro 
                245                 250             

<210>   2365
<211>   162
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   2365
ttgaaaagtc ttggaaaatg gtatgtctcg actggtaaag aatggatttg tcattcagat   60
gatgagctgg aagaatttaa aaatctattt ttaaatttta tcaatcctga agaatgggat   120
actatctcct ttgattcaga ttttatgccg tttcaacaat cg                      162

<210>   2366
<211>   54
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2366
Met Lys Ser Leu Gly Lys Trp Tyr Val Ser Thr Gly Lys Glu Trp Ile 
1               5                   10                  15      

Cys His Ser Asp Asp Glu Leu Glu Glu Phe Lys Asn Leu Phe Leu Asn 
            20                  25                  30          

Phe Ile Asn Pro Glu Glu Trp Asp Thr Ile Ser Phe Asp Ser Asp Phe 
        35                  40                  45              

Met Pro Phe Gln Gln Ser 
    50                  

<210>   2367
<211>   1413
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2367
gtgaaaaaaa tgacaaaaac acttccaaaa gactttattt ttggtggcgc aacagctgct   60
tatcaagcag aaggtgctac acatactgat ggaaaaggac cagttgcttg ggataaatat   120
cttgaggata actactggta cactgccgaa ccagctagtg atttttacaa tcgatatcca   180
gttgacctca agctagcaga agagtatggt gtcaatggta ttcgaatttc tattgcttgg   240
tcacgtattt tcccgactgg ttacggccaa gtaaatgcta aaggtgttga gttttatcat   300
aatttatttg cagagtgtca caaacgtcat gttgagcctt ttgtaactct tcatcacttt   360
gacacgccag aagctctcca ctcaaatgga gacttcttaa accgtgaaaa tatcgaacat   420
tttgtagact acgctgcctt ctgttttgaa gaatttccag aagtaaacta ttggacaacc   480
tttaatgaaa ttggaccaat cggtgatggt caatatttgg ttgggaaatt ccctccaggt   540
atccagtacg accttgccaa agtctttcaa tcacaccaca atatgatggt gtctcatgca   600
cgcgcggtaa aattgtacaa agagaaaggc tataaagggg aaattggtgt tgttcacgcc   660
ctgccaacta aatatcctct agatcctgaa aatccagcag atgttcgtgc agctgagttg   720
gaagatatca tccacaataa attcatctta gacgcaactt atctaggtcg ctattcagct   780
gaaaccatgg aaggtgtcaa ccatatctta ttagtcaatg gtggtagttt ggatcttcgt   840
gaagaagatt ttacagcatt agaagctgca aaagacttga atgatttcct aggaatcaac   900
tactatatga gtgactggat ggaagccttt gatggagaaa ctgaaattat ccataatggt   960
aaaggtgaaa aaggaagctc taagtatcaa atcaaaggtg ttggtcgtcg tgtagctcct   1020
gactatgtac cacgcacgga ttgggattgg attatctacc ctcaaggttt gtatgaccaa   1080
atcatgcgtg tgaagaaaga ttatcctaac tacaagaaga tttacatcac tgaaaatggt   1140
ctcggctata aagatgagtt cgttgataac actgtttacg atgatggtcg tattgattac   1200
gtgaagcaac acttggaggt tttatctgat gcgattgcag atggagctaa tgtaaaaggt   1260
tacttcattt ggtcattaat ggatgtcttc tcatggtcaa acggttatga gaaacgttat   1320
ggtctcttct acgtagattt tgaaactcaa gaacgttatc ctaagaaatc agctcactgg   1380
tacaagaaag tagcggaaac tcagattata gac                                1413

<210>   2368
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   6-phospho-beta-galactosidase (lacG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903112 (0.E+01)

<400>   2368
Met Lys Lys Met Thr Lys Thr Leu Pro Lys Asp Phe Ile Phe Gly Gly 
1               5                   10                  15      

Ala Thr Ala Ala Tyr Gln Ala Glu Gly Ala Thr His Thr Asp Gly Lys 
            20                  25                  30          

Gly Pro Val Ala Trp Asp Lys Tyr Leu Glu Asp Asn Tyr Trp Tyr Thr 
        35                  40                  45              

Ala Glu Pro Ala Ser Asp Phe Tyr Asn Arg Tyr Pro Val Asp Leu Lys 
    50                  55                  60                  

Leu Ala Glu Glu Tyr Gly Val Asn Gly Ile Arg Ile Ser Ile Ala Trp 
65                  70                  75                  80  

Ser Arg Ile Phe Pro Thr Gly Tyr Gly Gln Val Asn Ala Lys Gly Val 
                85                  90                  95      

Glu Phe Tyr His Asn Leu Phe Ala Glu Cys His Lys Arg His Val Glu 
            100                 105                 110         

Pro Phe Val Thr Leu His His Phe Asp Thr Pro Glu Ala Leu His Ser 
        115                 120                 125             

Asn Gly Asp Phe Leu Asn Arg Glu Asn Ile Glu His Phe Val Asp Tyr 
    130                 135                 140                 

Ala Ala Phe Cys Phe Glu Glu Phe Pro Glu Val Asn Tyr Trp Thr Thr 
145                 150                 155                 160 

Phe Asn Glu Ile Gly Pro Ile Gly Asp Gly Gln Tyr Leu Val Gly Lys 
                165                 170                 175     

Phe Pro Pro Gly Ile Gln Tyr Asp Leu Ala Lys Val Phe Gln Ser His 
            180                 185                 190         

His Asn Met Met Val Ser His Ala Arg Ala Val Lys Leu Tyr Lys Glu 
        195                 200                 205             

Lys Gly Tyr Lys Gly Glu Ile Gly Val Val His Ala Leu Pro Thr Lys 
    210                 215                 220                 

Tyr Pro Leu Asp Pro Glu Asn Pro Ala Asp Val Arg Ala Ala Glu Leu 
225                 230                 235                 240 

Glu Asp Ile Ile His Asn Lys Phe Ile Leu Asp Ala Thr Tyr Leu Gly 
                245                 250                 255     

Arg Tyr Ser Ala Glu Thr Met Glu Gly Val Asn His Ile Leu Leu Val 
            260                 265                 270         

Asn Gly Gly Ser Leu Asp Leu Arg Glu Glu Asp Phe Thr Ala Leu Glu 
        275                 280                 285             

Ala Ala Lys Asp Leu Asn Asp Phe Leu Gly Ile Asn Tyr Tyr Met Ser 
    290                 295                 300                 

Asp Trp Met Glu Ala Phe Asp Gly Glu Thr Glu Ile Ile His Asn Gly 
305                 310                 315                 320 

Lys Gly Glu Lys Gly Ser Ser Lys Tyr Gln Ile Lys Gly Val Gly Arg 
                325                 330                 335     

Arg Val Ala Pro Asp Tyr Val Pro Arg Thr Asp Trp Asp Trp Ile Ile 
            340                 345                 350         

Tyr Pro Gln Gly Leu Tyr Asp Gln Ile Met Arg Val Lys Lys Asp Tyr 
        355                 360                 365             

Pro Asn Tyr Lys Lys Ile Tyr Ile Thr Glu Asn Gly Leu Gly Tyr Lys 
    370                 375                 380                 

Asp Glu Phe Val Asp Asn Thr Val Tyr Asp Asp Gly Arg Ile Asp Tyr 
385                 390                 395                 400 

Val Lys Gln His Leu Glu Val Leu Ser Asp Ala Ile Ala Asp Gly Ala 
                405                 410                 415     

Asn Val Lys Gly Tyr Phe Ile Trp Ser Leu Met Asp Val Phe Ser Trp 
            420                 425                 430         

Ser Asn Gly Tyr Glu Lys Arg Tyr Gly Leu Phe Tyr Val Asp Phe Glu 
        435                 440                 445             

Thr Gln Glu Arg Tyr Pro Lys Lys Ser Ala His Trp Tyr Lys Lys Val 
    450                 455                 460                 

Ala Glu Thr Gln Ile Ile Asp 
465                 470     

<210>   2369
<211>   1689
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2369
atgaataaac taattgcatt tatcgagaaa ggaaagcctt tctttgaaaa actatctcgt   60
aatatctatc ttcgtgctat tcgtgatggt ttcattgcag gtatgcctgt tattctcttc   120
tcaagtatct ttatcttgat tgcctttgta ccaaactcat ggggctttaa atggtctgat   180
gaagttgtag cctttctgat gaaaccttat agctattcta tgggtattct ggctctcttg   240
gtagctggta caacagctaa gtcattgact gactcagtaa accggagcat ggaaaaaacc   300
aatcaaatca agtatatgtc aacattgttg gcagcaattg ttggtttgtt gatgttggca   360
gctgatccta tcgaaagtgg tctagctact ggattcttgg ggacaaaagg tttgctttca   420
gccttccttg ctgcctttgt tactgtagcc atctataagg tttgtgttaa gaacaacgtc   480
actattcgta tgcctgacga agttccacca aatatctcac aagtctttaa agatgtgatt   540
ccattcactc tatctgttgt ttctctttat gctcttgact tattagcacg ttattttgtt   600
ggttctagtg tggcagaatc aatcggtaaa ttcttcgcac cactcttctc agcagcagac   660
ggataccttg gtattaccat tatctttggt gcctttgcct tcttctggtt tgttgggatt   720
catggtccat ctatcgttga accagctatc gcagctatta cctatgccaa tgccgaagtt   780
aacttgaacc ttctccaaca agggatgcat gcagacaaga ttcttacttc tggtacacaa   840
atgtttatcg ttaccatggg tggtacaggt gcgacattgg tcgttccatt tatgttcatg   900
tggttgacaa aatcgaaacg taaccgtgca atcggacgtg cttcagtagt tcctaccttc   960
ttcggtgtaa atgaaccaat cttgtttggt gcacctcttg ttttgaatcc aatcttcttc   1020
attccattta tctttgctcc aattgcaaac gtatggattt tcaaattctt tattgaaact   1080
cttggaatga actcattcac tgctaatcta ccatggacaa ctccagctcc actaggtcta   1140
gttcttggaa ctaacttcca agtgctatca ttcattcttg ctgcccttct aatcgtggtt   1200
gacgttgtca tttactatcc attccttaag gtctatgatg aacaaattct tgaagaagaa   1260
cgttcaggta agtctaatga tgaattgaaa gaaaaagttg ctgcaaactt caacactgca   1320
aaagcggatg ctattcttga aaaagcgggt gtcgatgcag cacaaaatac catcactgaa   1380
gaaacaaatg tcctcgttct ctgtgcaggt ggaggaacaa gtggtctcct tgcaaatgct   1440
ttgaataagg cagcagcaga atacaatgtc cctgtgaaag cagcagcagg cggctatggt   1500
gctcaccgtg aaatgttacc agagtttgat cttgttatcc ttgcccctca agttgcttca   1560
aactttgaag atatgaaagc agaaacagat aagctcggta ttaaactagc gaaaacagaa   1620
ggcgctcaat acatcaaatt aactcgtgat ggaaaaggtg ctcttgcatt cgtacaagcg   1680
caattcgat                                                           1689

<210>   2370
<211>   563
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, lactose-specific IIBC components (lacE)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903113 (0.E+01)

<400>   2370
Met Asn Lys Leu Ile Ala Phe Ile Glu Lys Gly Lys Pro Phe Phe Glu 
1               5                   10                  15      

Lys Leu Ser Arg Asn Ile Tyr Leu Arg Ala Ile Arg Asp Gly Phe Ile 
            20                  25                  30          

Ala Gly Met Pro Val Ile Leu Phe Ser Ser Ile Phe Ile Leu Ile Ala 
        35                  40                  45              

Phe Val Pro Asn Ser Trp Gly Phe Lys Trp Ser Asp Glu Val Val Ala 
    50                  55                  60                  

Phe Leu Met Lys Pro Tyr Ser Tyr Ser Met Gly Ile Leu Ala Leu Leu 
65                  70                  75                  80  

Val Ala Gly Thr Thr Ala Lys Ser Leu Thr Asp Ser Val Asn Arg Ser 
                85                  90                  95      

Met Glu Lys Thr Asn Gln Ile Lys Tyr Met Ser Thr Leu Leu Ala Ala 
            100                 105                 110         

Ile Val Gly Leu Leu Met Leu Ala Ala Asp Pro Ile Glu Ser Gly Leu 
        115                 120                 125             

Ala Thr Gly Phe Leu Gly Thr Lys Gly Leu Leu Ser Ala Phe Leu Ala 
    130                 135                 140                 

Ala Phe Val Thr Val Ala Ile Tyr Lys Val Cys Val Lys Asn Asn Val 
145                 150                 155                 160 

Thr Ile Arg Met Pro Asp Glu Val Pro Pro Asn Ile Ser Gln Val Phe 
                165                 170                 175     

Lys Asp Val Ile Pro Phe Thr Leu Ser Val Val Ser Leu Tyr Ala Leu 
            180                 185                 190         


Asp Leu Leu Ala Arg Tyr Phe Val Gly Ser Ser Val Ala Glu Ser Ile 
        195                 200                 205             

Gly Lys Phe Phe Ala Pro Leu Phe Ser Ala Ala Asp Gly Tyr Leu Gly 
    210                 215                 220                 

Ile Thr Ile Ile Phe Gly Ala Phe Ala Phe Phe Trp Phe Val Gly Ile 
225                 230                 235                 240 

His Gly Pro Ser Ile Val Glu Pro Ala Ile Ala Ala Ile Thr Tyr Ala 
                245                 250                 255     

Asn Ala Glu Val Asn Leu Asn Leu Leu Gln Gln Gly Met His Ala Asp 
            260                 265                 270         

Lys Ile Leu Thr Ser Gly Thr Gln Met Phe Ile Val Thr Met Gly Gly 
        275                 280                 285             

Thr Gly Ala Thr Leu Val Val Pro Phe Met Phe Met Trp Leu Thr Lys 
    290                 295                 300                 

Ser Lys Arg Asn Arg Ala Ile Gly Arg Ala Ser Val Val Pro Thr Phe 
305                 310                 315                 320 

Phe Gly Val Asn Glu Pro Ile Leu Phe Gly Ala Pro Leu Val Leu Asn 
                325                 330                 335     

Pro Ile Phe Phe Ile Pro Phe Ile Phe Ala Pro Ile Ala Asn Val Trp 
            340                 345                 350         

Ile Phe Lys Phe Phe Ile Glu Thr Leu Gly Met Asn Ser Phe Thr Ala 
        355                 360                 365             

Asn Leu Pro Trp Thr Thr Pro Ala Pro Leu Gly Leu Val Leu Gly Thr 
    370                 375                 380                 

Asn Phe Gln Val Leu Ser Phe Ile Leu Ala Ala Leu Leu Ile Val Val 
385                 390                 395                 400 

Asp Val Val Ile Tyr Tyr Pro Phe Leu Lys Val Tyr Asp Glu Gln Ile 
                405                 410                 415     

Leu Glu Glu Glu Arg Ser Gly Lys Ser Asn Asp Glu Leu Lys Glu Lys 
            420                 425                 430         

Val Ala Ala Asn Phe Asn Thr Ala Lys Ala Asp Ala Ile Leu Glu Lys 
        435                 440                 445             

Ala Gly Val Asp Ala Ala Gln Asn Thr Ile Thr Glu Glu Thr Asn Val 
    450                 455                 460                 

Leu Val Leu Cys Ala Gly Gly Gly Thr Ser Gly Leu Leu Ala Asn Ala 
465                 470                 475                 480 

Leu Asn Lys Ala Ala Ala Glu Tyr Asn Val Pro Val Lys Ala Ala Ala 
                485                 490                 495     

Gly Gly Tyr Gly Ala His Arg Glu Met Leu Pro Glu Phe Asp Leu Val 
            500                 505                 510         

Ile Leu Ala Pro Gln Val Ala Ser Asn Phe Glu Asp Met Lys Ala Glu 
        515                 520                 525             

Thr Asp Lys Leu Gly Ile Lys Leu Ala Lys Thr Glu Gly Ala Gln Tyr 
    530                 535                 540                 

Ile Lys Leu Thr Arg Asp Gly Lys Gly Ala Leu Ala Phe Val Gln Ala 
545                 550                 555                 560 

Gln Phe Asp 
            

<210>   2371
<211>   315
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2371
atgaatagag aagaagtaac attgttaggt tttgaaatcg tagcctatgc tggcgatgct   60
cgttcaaaac tattggaagc cttgaaggct gctgaagctg gtgattttga aaaagcggac   120
gctctggtag aggaagctgg tagctgtatt gcagaggctc accacgcgca aacaagtcta   180
ttgactaagg aagcttcagg tgaggacttg gcttatagtg taaccatgat gcatggccaa   240
gaccacttaa tgacaactat cttgttaaaa gatttgatgc atcatttaat tgaactctac   300
aagagaggag ttcaa                                                    315

<210>   2372
<211>   105
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, lactose-specific IIA component (lacF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903114 (5.E-55)

<400>   2372
Met Asn Arg Glu Glu Val Thr Leu Leu Gly Phe Glu Ile Val Ala Tyr 
1               5                   10                  15      

Ala Gly Asp Ala Arg Ser Lys Leu Leu Glu Ala Leu Lys Ala Ala Glu 
            20                  25                  30          

Ala Gly Asp Phe Glu Lys Ala Asp Ala Leu Val Glu Glu Ala Gly Ser 
        35                  40                  45              

Cys Ile Ala Glu Ala His His Ala Gln Thr Ser Leu Leu Thr Lys Glu 
    50                  55                  60                  

Ala Ser Gly Glu Asp Leu Ala Tyr Ser Val Thr Met Met His Gly Gln 
65                  70                  75                  80  

Asp His Leu Met Thr Thr Ile Leu Leu Lys Asp Leu Met His His Leu 
                85                  90                  95      

Ile Glu Leu Tyr Lys Arg Gly Val Gln 
            100                 105 

<210>   2373
<211>   834
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2373
atgtatcgaa ttctaaatcc aatgaatcac aatgtctcgc ttgtcagaaa tgataaggga   60
gaagaggtga ttgtaattgg taagggaatt gcattcggaa agaagaaggg ggatttgatt   120
gctgaaaatc aggttgagaa aatctttcgg atgaagaccg aagagtccag agaaaacttt   180
atggctcttc tcaaagatgt tccgcttgat tttatcacag tgacctatga aatcattgat   240
aagctatcaa agaaatatca ttatccgatt caagagtatc tctatgtaac cttgacagat   300
catatttact gttcttatca agctctaact caaggaaggt acaaggatag taatctgcca   360
gatatttccg ctaagtatcc tgtcgctttt caaatcgcaa atgaagcttt tgaaatttac   420
cgtcagaagc tagcagatca ttttcctgag gacgaaatta ttcggattgc ttatcatttc   480
attaatgctg aaggtgaaaa tgaagtggaa cttgtggagt cgattgataa gaggaaagaa   540
attctcagga atgttgaaga agttttaacg gactatgcaa ttcaacgaac taaaaagaat   600
aaccatttct atgatcgctt tatgatccat ttgaattatt tcttggatta tttagacaga   660
tctagagatg ataaccaatc acttctggat atggaagatc atattaaaca atcctatcca   720
aaagccttcg agattggttc caagatctat gatgtgatta cgcaacatac gggtcttgat   780
ttgtataaaa gtgaacgagt ttatctagtt ctacatatcc aacgtttatt gtca         834

<210>   2374
<211>   278
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcription antiterminator LacT (lacT)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903115 (e-159)

<400>   2374
Met Tyr Arg Ile Leu Asn Pro Met Asn His Asn Val Ser Leu Val Arg 
1               5                   10                  15      

Asn Asp Lys Gly Glu Glu Val Ile Val Ile Gly Lys Gly Ile Ala Phe 
            20                  25                  30          

Gly Lys Lys Lys Gly Asp Leu Ile Ala Glu Asn Gln Val Glu Lys Ile 
        35                  40                  45              

Phe Arg Met Lys Thr Glu Glu Ser Arg Glu Asn Phe Met Ala Leu Leu 
    50                  55                  60                  

Lys Asp Val Pro Leu Asp Phe Ile Thr Val Thr Tyr Glu Ile Ile Asp 
65                  70                  75                  80  

Lys Leu Ser Lys Lys Tyr His Tyr Pro Ile Gln Glu Tyr Leu Tyr Val 
                85                  90                  95      

Thr Leu Thr Asp His Ile Tyr Cys Ser Tyr Gln Ala Leu Thr Gln Gly 
            100                 105                 110         

Arg Tyr Lys Asp Ser Asn Leu Pro Asp Ile Ser Ala Lys Tyr Pro Val 
        115                 120                 125             

Ala Phe Gln Ile Ala Asn Glu Ala Phe Glu Ile Tyr Arg Gln Lys Leu 
    130                 135                 140                 

Ala Asp His Phe Pro Glu Asp Glu Ile Ile Arg Ile Ala Tyr His Phe 
145                 150                 155                 160 

Ile Asn Ala Glu Gly Glu Asn Glu Val Glu Leu Val Glu Ser Ile Asp 
                165                 170                 175     

Lys Arg Lys Glu Ile Leu Arg Asn Val Glu Glu Val Leu Thr Asp Tyr 
            180                 185                 190         

Ala Ile Gln Arg Thr Lys Lys Asn Asn His Phe Tyr Asp Arg Phe Met 
        195                 200                 205             

Ile His Leu Asn Tyr Phe Leu Asp Tyr Leu Asp Arg Ser Arg Asp Asp 
    210                 215                 220                 

Asn Gln Ser Leu Leu Asp Met Glu Asp His Ile Lys Gln Ser Tyr Pro 
225                 230                 235                 240 

Lys Ala Phe Glu Ile Gly Ser Lys Ile Tyr Asp Val Ile Thr Gln His 
                245                 250                 255     

Thr Gly Leu Asp Leu Tyr Lys Ser Glu Arg Val Tyr Leu Val Leu His 
            260                 265                 270         

Ile Gln Arg Leu Leu Ser 
        275             

<210>   2375
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2375
atgaatcatt cttttaaaaa aataactgta ttttgtttta tagtttcttg tgttctttgt   60
ttattagact taatgaattt taaaaatgta gctacttttt tatttttctg tcttcctgtt   120
tttgttttga tttacaaaaa taaa                                          144

<210>   2376
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   2376
Met Asn His Ser Phe Lys Lys Ile Thr Val Phe Cys Phe Ile Val Ser 
1               5                   10                  15      

Cys Val Leu Cys Leu Leu Asp Leu Met Asn Phe Lys Asn Val Ala Thr 
            20                  25                  30          

Phe Leu Phe Phe Cys Leu Pro Val Phe Val Leu Ile Tyr Lys Asn Lys 
        35                  40                  45              


<210>   2377
<211>   540
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2377
atggttagtg gttctgtatt tgcagatagt gccctaacta cagtagataa agcaaatgat   60
attgttttga atgttgatgg gaataaattt tataatgttt cggtttcaga agatattgta   120
aatgctggtc aaattttgga agattatttt tatgtagata aatttggaaa tataaattta   180
aaaggcactc ctgaagagtt agcaaaaaat attggtattt ctgtacaaga agcaagtttg   240
atgtatggag ctgtaaaaga gttacccaac gtttacgaaa gaggtcctgt aggttttcgt   300
ttcaatcttg gtcctcaagt gagggggatg ggtggctggg ctgctggagc tttcgctact   360
ggatatgctg gatggcattt gaaacaattt gcggttaatc ctgttacatc tggatttgtt   420
gctgtaataa gtggtgcgat tggctgggct gtaaaaactg ctgtagaaaa ttattggaca   480
gttgctgtag ctacagtaga agtgccgttt gtgaaccttg tttacaccat agatttacct   540

<210>   2378
<211>   180
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   2378
Met Val Ser Gly Ser Val Phe Ala Asp Ser Ala Leu Thr Thr Val Asp 
1               5                   10                  15      

Lys Ala Asn Asp Ile Val Leu Asn Val Asp Gly Asn Lys Phe Tyr Asn 
            20                  25                  30          

Val Ser Val Ser Glu Asp Ile Val Asn Ala Gly Gln Ile Leu Glu Asp 
        35                  40                  45              

Tyr Phe Tyr Val Asp Lys Phe Gly Asn Ile Asn Leu Lys Gly Thr Pro 
    50                  55                  60                  

Glu Glu Leu Ala Lys Asn Ile Gly Ile Ser Val Gln Glu Ala Ser Leu 
65                  70                  75                  80  

Met Tyr Gly Ala Val Lys Glu Leu Pro Asn Val Tyr Glu Arg Gly Pro 
                85                  90                  95      

Val Gly Phe Arg Phe Asn Leu Gly Pro Gln Val Arg Gly Met Gly Gly 
            100                 105                 110         

Trp Ala Ala Gly Ala Phe Ala Thr Gly Tyr Ala Gly Trp His Leu Lys 
        115                 120                 125             

Gln Phe Ala Val Asn Pro Val Thr Ser Gly Phe Val Ala Val Ile Ser 
    130                 135                 140                 

Gly Ala Ile Gly Trp Ala Val Lys Thr Ala Val Glu Asn Tyr Trp Thr 
145                 150                 155                 160 

Val Ala Val Ala Thr Val Glu Val Pro Phe Val Asn Leu Val Tyr Thr 
                165                 170                 175     

Ile Asp Leu Pro 
            180 

<210>   2379

<211>   978
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2379
atggctttaa cagaacaaaa acgtgtacgc ttagaaaaac tttctgatga aaatggtatc   60
atctcagctc ttgcatttga ccaacgtggt gctttgaaac gcctcatggt taaacaccaa   120
acagaagaac caactgtggc ccaaatggaa gaacttaaag tcttggtagc agatgaattg   180
actaaatatg cttcatctat gcttcttgac cctgagtatg gacttccagc aactaaagct   240
cttgatgaaa aagctggtct tctccttgct tatgaaaaaa caggttatga cacaacaagc   300
acaaaacgct tgccagactg cttggatgtt tggtctgcaa aacgtattaa agaagaaggt   360
gcagatgcag ttaaattctt gctttactat gatgtagata gctcagacga actcaatcaa   420
gaaaaacaag cctacatcga acgcatcggt tctgagtgtg tggctgaaga tatcccattc   480
ttccttgaaa tccttgctta cgatgaaaaa attgcggatg caggttctgt agaatacgct   540
aaagtaaaac cacacaaagt tatcggcgct atgaaagtct tttcagaccc acgctttaac   600
attgatgttt tgaaagttga agttcctgtt aacattaaat atgttgaagg cttcgctgaa   660
ggtgaagtag tttatacacg tgaagaagca gcagccttct tcaaagcgca agatgaagca   720
acgaacttgc catacatcta cttgagtgct ggtgtatcag ctaaactctt ccaagatact   780

cttgtatttg ctcatgaatc aggtgcgaac tttaacggag ttctttgtgg ccgtgctaca   840
tgggcaggat cagttgaagc ttacatcaaa gatggtgaag cagcagctcg cgaatgcgtt   900
cgcacaactg gatttgaaaa cattgacgaa ctcaacaaag ttcttcaaag aacagcaact   960
tcatggaaag aacgcgtg                                                 978

<210>   2380
<211>   326
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tagatose 1,6-diphosphate aldolase (lacD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903116 (0.E+01)

<400>   2380
Met Ala Leu Thr Glu Gln Lys Arg Val Arg Leu Glu Lys Leu Ser Asp 
1               5                   10                  15      

Glu Asn Gly Ile Ile Ser Ala Leu Ala Phe Asp Gln Arg Gly Ala Leu 
            20                  25                  30          

Lys Arg Leu Met Val Lys His Gln Thr Glu Glu Pro Thr Val Ala Gln 
        35                  40                  45              

Met Glu Glu Leu Lys Val Leu Val Ala Asp Glu Leu Thr Lys Tyr Ala 
    50                  55                  60                  

Ser Ser Met Leu Leu Asp Pro Glu Tyr Gly Leu Pro Ala Thr Lys Ala 
65                  70                  75                  80  

Leu Asp Glu Lys Ala Gly Leu Leu Leu Ala Tyr Glu Lys Thr Gly Tyr 
                85                  90                  95      

Asp Thr Thr Ser Thr Lys Arg Leu Pro Asp Cys Leu Asp Val Trp Ser 
            100                 105                 110         

Ala Lys Arg Ile Lys Glu Glu Gly Ala Asp Ala Val Lys Phe Leu Leu 
        115                 120                 125             

Tyr Tyr Asp Val Asp Ser Ser Asp Glu Leu Asn Gln Glu Lys Gln Ala 
    130                 135                 140                 

Tyr Ile Glu Arg Ile Gly Ser Glu Cys Val Ala Glu Asp Ile Pro Phe 
145                 150                 155                 160 

Phe Leu Glu Ile Leu Ala Tyr Asp Glu Lys Ile Ala Asp Ala Gly Ser 
                165                 170                 175     

Val Glu Tyr Ala Lys Val Lys Pro His Lys Val Ile Gly Ala Met Lys 
            180                 185                 190         

Val Phe Ser Asp Pro Arg Phe Asn Ile Asp Val Leu Lys Val Glu Val 
        195                 200                 205             

Pro Val Asn Ile Lys Tyr Val Glu Gly Phe Ala Glu Gly Glu Val Val 
    210                 215                 220                 

Tyr Thr Arg Glu Glu Ala Ala Ala Phe Phe Lys Ala Gln Asp Glu Ala 
225                 230                 235                 240 

Thr Asn Leu Pro Tyr Ile Tyr Leu Ser Ala Gly Val Ser Ala Lys Leu 
                245                 250                 255     

Phe Gln Asp Thr Leu Val Phe Ala His Glu Ser Gly Ala Asn Phe Asn 
            260                 265                 270         

Gly Val Leu Cys Gly Arg Ala Thr Trp Ala Gly Ser Val Glu Ala Tyr 
        275                 280                 285             

Ile Lys Asp Gly Glu Ala Ala Ala Arg Glu Cys Val Arg Thr Thr Gly 
    290                 295                 300                 

Phe Glu Asn Ile Asp Glu Leu Asn Lys Val Leu Gln Arg Thr Ala Thr 
305                 310                 315                 320 

Ser Trp Lys Glu Arg Val 
                325     

<210>   2381
<211>   927
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2381
atgattttaa cagtcacaat gaacccatcc atcgatattt cctatccctt ggatgagttg   60
aagattgata ctgtcaatcg tgtggtggat gtaaccaaaa cggctggtgg taagggactc   120
aatgttaccc gagtactttc agaatttggc gattctgttc ttgctactgg tttagtgggt   180
ggcaaacttg gtgagttttt ggttgaacat atcgataatc aagtaaagaa agatttcttc   240
tcaattaagg gagaaactcg taactgtatc gctattctcc acggagacaa ccaaacagaa   300
gttcttgaaa aaggtcctga agtattggaa caggaaggtc aagagttttt ggaacatttc   360
aaaaaactct tggagtcagt tgaagtagta gccatctcag gtagtctgcc agctggcctt   420
ccagttgatt actatgcgag cttggtagaa cttgctaatc aagctggcaa gcatgtagtc   480
ttggactgct caggtgcagc acttcaggct gttcttgaat caccccataa accaacagtc   540
atcaaaccaa ataatgaaga attgtctcag cttcttggaa gagaagtttc tgaggatttg   600
gatgaattaa aagaagtact tcaagaacct ttgtttgcag ggattgaatg gattatcgtt   660
tcacttggtg ccaacggtac ttttgccaaa catggtgaca ctttctacaa ggtagatatt   720
cctagaattc aggtggtaaa tcctgttgga tctggagact ctactgtggc aggaatttct   780
tcaggacttc ttcacaaaga atcggatgca gaattactca tcaaggcaaa tgtccttggt   840
atgctcaatg ctcaagaaaa aatgactggt catgtcaaca tggccaacta tcaagctcta   900
tatgatcaat taatagtaaa agaggta                                       927

<210>   2382
<211>   309
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tagatose-6-phosphate kinase (lacC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903117 (e-172)

<400>   2382
Met Ile Leu Thr Val Thr Met Asn Pro Ser Ile Asp Ile Ser Tyr Pro 
1               5                   10                  15      

Leu Asp Glu Leu Lys Ile Asp Thr Val Asn Arg Val Val Asp Val Thr 
            20                  25                  30          

Lys Thr Ala Gly Gly Lys Gly Leu Asn Val Thr Arg Val Leu Ser Glu 
        35                  40                  45              

Phe Gly Asp Ser Val Leu Ala Thr Gly Leu Val Gly Gly Lys Leu Gly 
    50                  55                  60                  

Glu Phe Leu Val Glu His Ile Asp Asn Gln Val Lys Lys Asp Phe Phe 
65                  70                  75                  80  

Ser Ile Lys Gly Glu Thr Arg Asn Cys Ile Ala Ile Leu His Gly Asp 
                85                  90                  95      

Asn Gln Thr Glu Val Leu Glu Lys Gly Pro Glu Val Leu Glu Gln Glu 
            100                 105                 110         

Gly Gln Glu Phe Leu Glu His Phe Lys Lys Leu Leu Glu Ser Val Glu 
        115                 120                 125             

Val Val Ala Ile Ser Gly Ser Leu Pro Ala Gly Leu Pro Val Asp Tyr 
    130                 135                 140                 

Tyr Ala Ser Leu Val Glu Leu Ala Asn Gln Ala Gly Lys His Val Val 
145                 150                 155                 160 

Leu Asp Cys Ser Gly Ala Ala Leu Gln Ala Val Leu Glu Ser Pro His 
                165                 170                 175     

Lys Pro Thr Val Ile Lys Pro Asn Asn Glu Glu Leu Ser Gln Leu Leu 
            180                 185                 190         

Gly Arg Glu Val Ser Glu Asp Leu Asp Glu Leu Lys Glu Val Leu Gln 
        195                 200                 205             

Glu Pro Leu Phe Ala Gly Ile Glu Trp Ile Ile Val Ser Leu Gly Ala 
    210                 215                 220                 

Asn Gly Thr Phe Ala Lys His Gly Asp Thr Phe Tyr Lys Val Asp Ile 
225                 230                 235                 240 

Pro Arg Ile Gln Val Val Asn Pro Val Gly Ser Gly Asp Ser Thr Val 
                245                 250                 255     

Ala Gly Ile Ser Ser Gly Leu Leu His Lys Glu Ser Asp Ala Glu Leu 
            260                 265                 270         

Leu Ile Lys Ala Asn Val Leu Gly Met Leu Asn Ala Gln Glu Lys Met 
        275                 280                 285             

Thr Gly His Val Asn Met Ala Asn Tyr Gln Ala Leu Tyr Asp Gln Leu 
    290                 295                 300                 

Ile Val Lys Glu Val 
305                 

<210>   2383
<211>   486
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2383
atggatgggt tcattgtgac tgttaaaatc ataggtcacc tcttagtcgt ggtattctcc   60
acgatcccat ttctcaagga attctgtaaa gaagtttgcg tctgtttgtt gagcattgtg   120
actttcaaca tgttcaattt tcgcaatcaa ttttttgttt tcttcagttg gtttgtattc   180
agcatggatg aaagcttcga tgatatcaca cataagcaat tcaccagtaa ttttaccacc   240
aaaaccaata acgttagcgt tcaattgttc tttagcataa agggctgttg tcatatcacg   300
aaccaaggca gaacgaacac ctggaacttt atttacagcg ttgttgatac caacaccagt   360
accacagata catactccaa gatcagcttg accgctagtt acagcttccc ctactttttt   420
accaaagatt gggtagtgag tccgtgtatg gtcataggta ccaaagtcaa tgacttcata   480
tccttt                                                              486

<210>   2384
<211>   162
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2384
Met Asp Gly Phe Ile Val Thr Val Lys Ile Ile Gly His Leu Leu Val 
1               5                   10                  15      

Val Val Phe Ser Thr Ile Pro Phe Leu Lys Glu Phe Cys Lys Glu Val 
            20                  25                  30          

Cys Val Cys Leu Leu Ser Ile Val Thr Phe Asn Met Phe Asn Phe Arg 
        35                  40                  45              


Asn Gln Phe Phe Val Phe Phe Ser Trp Phe Val Phe Ser Met Asp Glu 
    50                  55                  60                  

Ser Phe Asp Asp Ile Thr His Lys Gln Phe Thr Ser Asn Phe Thr Thr 
65                  70                  75                  80  

Lys Thr Asn Asn Val Ser Val Gln Leu Phe Phe Ser Ile Lys Gly Cys 
                85                  90                  95      

Cys His Ile Thr Asn Gln Gly Arg Thr Asn Thr Trp Asn Phe Ile Tyr 
            100                 105                 110         

Ser Val Val Asp Thr Asn Thr Ser Thr Thr Asp Thr Tyr Ser Lys Ile 
        115                 120                 125             

Ser Leu Thr Ala Ser Tyr Ser Phe Pro Tyr Phe Phe Thr Lys Asp Trp 
    130                 135                 140                 

Val Val Ser Pro Cys Met Val Ile Gly Thr Lys Val Asn Asp Phe Ile 
145                 150                 155                 160 

Ser Phe 
        

<210>   2385
<211>   513
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2385
atgagaattg caattggatg tgaccacatc gtaactgatg aaaaaatggc ggtttcagaa   60
tttttgaaat caaaaggata tgaagtcatt gactttggta cctatgacca tacacggact   120
cactacccaa tctttggtaa aaaagtaggg gaagctgtaa ctagcggtca agctgatctt   180
ggagtatgta tctgtggtac tggtgttggt atcaacaacg ctgtaaataa agttccaggt   240
gttcgttctg ccttggttcg tgatatgaca acagcccttt atgctaaaga acaattgaac   300
gctaacgtta ttggttttgg tggtaaaatt actggtgaat tgcttatgtg tgatatcatc   360
gaagctttca tccatgctga atacaaacca actgaagaaa acaaaaaatt gattgcgaaa   420
attgaacatg ttgaaagtca caatgctcaa caaacagacg caaacttctt tacagaattc   480
cttgagaaat gggatcgtgg agaataccac gac                                513

<210>   2386
<211>   171
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   galactose-6-phosphate isomerase, LacB subunit (lacB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903118 (3.E-98)

<400>   2386
Met Arg Ile Ala Ile Gly Cys Asp His Ile Val Thr Asp Glu Lys Met 
1               5                   10                  15      

Ala Val Ser Glu Phe Leu Lys Ser Lys Gly Tyr Glu Val Ile Asp Phe 
            20                  25                  30          

Gly Thr Tyr Asp His Thr Arg Thr His Tyr Pro Ile Phe Gly Lys Lys 
        35                  40                  45              

Val Gly Glu Ala Val Thr Ser Gly Gln Ala Asp Leu Gly Val Cys Ile 
    50                  55                  60                  

Cys Gly Thr Gly Val Gly Ile Asn Asn Ala Val Asn Lys Val Pro Gly 
65                  70                  75                  80  

Val Arg Ser Ala Leu Val Arg Asp Met Thr Thr Ala Leu Tyr Ala Lys 
                85                  90                  95      

Glu Gln Leu Asn Ala Asn Val Ile Gly Phe Gly Gly Lys Ile Thr Gly 
            100                 105                 110         

Glu Leu Leu Met Cys Asp Ile Ile Glu Ala Phe Ile His Ala Glu Tyr 
        115                 120                 125             

Lys Pro Thr Glu Glu Asn Lys Lys Leu Ile Ala Lys Ile Glu His Val 
    130                 135                 140                 

Glu Ser His Asn Ala Gln Gln Thr Asp Ala Asn Phe Phe Thr Glu Phe 
145                 150                 155                 160 

Leu Glu Lys Trp Asp Arg Gly Glu Tyr His Asp 
                165                 170     

<210>   2387
<211>   423
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2387
atgtctattg ttatcggtgc agatgctgca ggtttgagat tgaaagaagt tgtgaaagac   60
ttcttagaaa aagaaaactt ccaccttgtg gatgttacag ctgaaggtca agactttgtt   120
gatgtgactc tcgctgttgc tgcagaagta aacaaagaag aacaaaacct tggtatcgtg   180
attgatgctt atggagctgg tccatttata gttgcaacta agatcaaagg aatggttgct   240
gcagaagtat ctgacgaacg ttcagcttat atgactcgtg gccacaacaa ctcacgtatg   300
atcactatgg gagcacaact tgttggtgat gaattggcta aaaatatcgc taaaggattt   360
gttaatggta aatacgacgg tggtcgtcac caaatccggg ttgacatgtt gaacaaaatg   420
ggc                                                                 423

<210>   2388
<211>   141
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   galactose-6-phosphate isomerase, LacA subunit (lacA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903119 (6.E-76)

<400>   2388
Met Ser Ile Val Ile Gly Ala Asp Ala Ala Gly Leu Arg Leu Lys Glu 
1               5                   10                  15      

Val Val Lys Asp Phe Leu Glu Lys Glu Asn Phe His Leu Val Asp Val 
            20                  25                  30          

Thr Ala Glu Gly Gln Asp Phe Val Asp Val Thr Leu Ala Val Ala Ala 
        35                  40                  45              

Glu Val Asn Lys Glu Glu Gln Asn Leu Gly Ile Val Ile Asp Ala Tyr 
    50                  55                  60                  

Gly Ala Gly Pro Phe Ile Val Ala Thr Lys Ile Lys Gly Met Val Ala 
65                  70                  75                  80  

Ala Glu Val Ser Asp Glu Arg Ser Ala Tyr Met Thr Arg Gly His Asn 
                85                  90                  95      

Asn Ser Arg Met Ile Thr Met Gly Ala Gln Leu Val Gly Asp Glu Leu 
            100                 105                 110         

Ala Lys Asn Ile Ala Lys Gly Phe Val Asn Gly Lys Tyr Asp Gly Gly 
        115                 120                 125             

Arg His Gln Ile Arg Val Asp Met Leu Asn Lys Met Gly 
    130                 135                 140     

<210>   2389
<211>   342
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2389
atgttggatt tccaagatag aagtccatgg ctagagggac aaaaagaaat agatcttagt   60
tatgatcttt tcagcacaga tgcagtgact ttggatgaat tgcaatctcg aacaattgcc   120
cttcgttctc ttaaacatga taagggattg aaagtgcatt ttgcagaatt tccaaacctc   180
atcatctggt caactttgaa caagggacct ttcattacct ttgaaccatg gtctggcttg   240
tcaacatccc ttgaagaagg agatcattta gaagataaga agaatgtttg tctcttagaa   300
gccaatcagg ttgaagaatt agggtttgag atagaagttt ta                      342

<210>   2390
<211>   114
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lacX protein, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903120 (1.E-62)

<400>   2390
Met Leu Asp Phe Gln Asp Arg Ser Pro Trp Leu Glu Gly Gln Lys Glu 
1               5                   10                  15      

Ile Asp Leu Ser Tyr Asp Leu Phe Ser Thr Asp Ala Val Thr Leu Asp 
            20                  25                  30          

Glu Leu Gln Ser Arg Thr Ile Ala Leu Arg Ser Leu Lys His Asp Lys 
        35                  40                  45              

Gly Leu Lys Val His Phe Ala Glu Phe Pro Asn Leu Ile Ile Trp Ser 
    50                  55                  60                  

Thr Leu Asn Lys Gly Pro Phe Ile Thr Phe Glu Pro Trp Ser Gly Leu 
65                  70                  75                  80  

Ser Thr Ser Leu Glu Glu Gly Asp His Leu Glu Asp Lys Lys Asn Val 
                85                  90                  95      

Cys Leu Leu Glu Ala Asn Gln Val Glu Glu Leu Gly Phe Glu Ile Glu 
            100                 105                 110         

Val Leu 
        

<210>   2391
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2391
atgaaggctc aagcgattgt cacaagtcaa gggagaattg tttctttgga tatcactgtg   60
aactattgtc atgatatgaa gttgttcaaa atgagtcgca gaaatatcgg acaagctggt   120
aaaatcttgg ctgacagtgg ttatcaagga cccatgaaga tatatcctca agcacaaact   180
ccacgtaaat ccagcaaact caagccgcta acagttgaag ataaagccta taaccatgcg   240
ctatctaagg agagaagcaa ggttgagaac atctttgcca aagtaaaaac gtttaaaatg   300
ttttcaacaa cctatcgaaa tcatcgtaaa cgcttcggat tacgaatgaa tttgattgct   360
ggtattatca atcatgaact aggattc                                       387

<210>   2392
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfB FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902885 (5.E-67)

<400>   2392
Met Lys Ala Gln Ala Ile Val Thr Ser Gln Gly Arg Ile Val Ser Leu 
1               5                   10                  15      

Asp Ile Thr Val Asn Tyr Cys His Asp Met Lys Leu Phe Lys Met Ser 
            20                  25                  30          

Arg Arg Asn Ile Gly Gln Ala Gly Lys Ile Leu Ala Asp Ser Gly Tyr 
        35                  40                  45              

Gln Gly Pro Met Lys Ile Tyr Pro Gln Ala Gln Thr Pro Arg Lys Ser 
    50                  55                  60                  

Ser Lys Leu Lys Pro Leu Thr Val Glu Asp Lys Ala Tyr Asn His Ala 
65                  70                  75                  80  

Leu Ser Lys Glu Arg Ser Lys Val Glu Asn Ile Phe Ala Lys Val Lys 
                85                  90                  95      

Thr Phe Lys Met Phe Ser Thr Thr Tyr Arg Asn His Arg Lys Arg Phe 
            100                 105                 110         

Gly Leu Arg Met Asn Leu Ile Ala Gly Ile Ile Asn His Glu Leu Gly 
        115                 120                 125             

Phe 
    

<210>   2393
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2393
ttgttcaaag gtggtgttac gatttcaaga actcctctca gttctgaaga cacggtaatg   60
attgatgcga cggaagtaaa aatcaatcga cctaaaaaaa gaattagcga attattctgg   120

<210>   2394
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, putative, FRAMESHIFT

<400>   2394
Met Phe Lys Gly Gly Val Thr Ile Ser Arg Thr Pro Leu Ser Ser Glu 
1               5                   10                  15      

Asp Thr Val Met Ile Asp Ala Thr Glu Val Lys Ile Asn Arg Pro Lys 
            20                  25                  30          

Lys Arg Ile Ser Glu Leu Phe Trp 
        35                  40  

<210>   2395
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2395
ttgattttta cttccgtcgc atcaatcatt accgtgtctt cagaactgag aggagttctt   60
gaaatcgtaa caccaccttt gaacaagagt tacttcaacc cattggctcc gacggag      117


<210>   2396
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2396
Met Ile Phe Thr Ser Val Ala Ser Ile Ile Thr Val Ser Ser Glu Leu 
1               5                   10                  15      

Arg Gly Val Leu Glu Ile Val Thr Pro Pro Leu Asn Lys Ser Tyr Phe 
            20                  25                  30          

Asn Pro Leu Ala Pro Thr Glu 
        35                  

<210>   2397
<211>   397
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2397
atgaatgatg aagcaagtaa acaactaact gatacacgat ttaaatgtct tgttggtgtt   60
cagcgcacga cttttgaaga gatgttagct gtgttaaaaa cagcttatca acttaaacac   120
gcaaaaggtg gacgaaaacc taaattaagc ctagaagacc ttcttatggc cactcttcac   180

tatgtgcgag aataccgcac ttatgaagaa attgcggctg attttggtat ccacgaaagc   240
aacttactcc gtcggagcca atgggttgaa gtaactcttg ttcaaaggtg gtgttacgat   300
ttcaagaact cctctcagtt ctgaagacac ggtaatgatt gatgcgacgg aagtaaaaat   360
caatcgacct aaaaaaagaa ttagcgaatt attctgg                            397

<210>   2398
<211>   107
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA FRAMESHIFT

<400>   2398
Met Asn Asp Glu Ala Ser Lys Gln Leu Thr Asp Thr Arg Phe Lys Cys 
1               5                   10                  15      

Leu Val Gly Val Gln Arg Thr Thr Phe Glu Glu Met Leu Ala Val Leu 
            20                  25                  30          

Lys Thr Ala Tyr Gln Leu Lys His Ala Lys Gly Gly Arg Lys Pro Lys 
        35                  40                  45              

Leu Ser Leu Glu Asp Leu Leu Met Ala Thr Leu His Tyr Val Arg Glu 
    50                  55                  60                  

Tyr Arg Thr Tyr Glu Glu Ile Ala Ala Asp Phe Gly Ile His Glu Ser 
65                  70                  75                  80  

Asn Leu Leu Arg Arg Ser Gln Trp Val Glu Val Thr Leu Val Gln Arg 
                85                  90                  95      

Trp Cys Tyr Asp Phe Lys Asn Ser Ser Gln Phe 
            100                 105         

<210>   2399
<211>   300
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2399
atgattaaaa ttcttgctgc ctgcggtgca ggtgttaact caagtcacca aattaaaagt   60
gctctagaag aagaactttc aaaccgtggt tacgatgttc actgtgatgc agttatggtg   120
aaagatgtaa acgaagacct tatgaaaggt tacgatatct ttacaccaat cgctgcaaca   180
gaccttggtt ttgaaccagg tatcccagtt atcgaagctg ggccaatctt attccgtatc   240
ccagcaatga gcgttccagt atttgacaat attagacttc ctgcgaaaca aaacatggta   300


<210>   2400
<211>   100
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903123 (1.E-52)

<400>   2400
Met Ile Lys Ile Leu Ala Ala Cys Gly Ala Gly Val Asn Ser Ser His 
1               5                   10                  15      

Gln Ile Lys Ser Ala Leu Glu Glu Glu Leu Ser Asn Arg Gly Tyr Asp 
            20                  25                  30          

Val His Cys Asp Ala Val Met Val Lys Asp Val Asn Glu Asp Leu Met 
        35                  40                  45              

Lys Gly Tyr Asp Ile Phe Thr Pro Ile Ala Ala Thr Asp Leu Gly Phe 
    50                  55                  60                  

Glu Pro Gly Ile Pro Val Ile Glu Ala Gly Pro Ile Leu Phe Arg Ile 
65                  70                  75                  80  

Pro Ala Met Ser Val Pro Val Phe Asp Asn Ile Arg Leu Pro Ala Lys 
                85                  90                  95      

Gln Asn Met Val 
            100 

<210>   2401
<211>   270
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2401
atgattcctc acacagatat tgttcataat ctagctgaga aagtggtggt tgttcgatta   60
gagaaaccgg tgactttcca taatatgatt gcgccaggta aggaagtaga agtatccttg   120
ctcttcttta tcatcaataa ttcaagttca agtcaaacga acattcttgc tcagttaatg   180
gacttcttca caggaaatgg tcatcttgaa gacctatcaa aaatttctga accagaagcc   240
ctttatgctt acattgctga agcaaccgct                                    270

<210>   2402
<211>   90
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903124 (5.E-45)

<400>   2402
Met Ile Pro His Thr Asp Ile Val His Asn Leu Ala Glu Lys Val Val 
1               5                   10                  15      

Val Val Arg Leu Glu Lys Pro Val Thr Phe His Asn Met Ile Ala Pro 
            20                  25                  30          

Gly Lys Glu Val Glu Val Ser Leu Leu Phe Phe Ile Ile Asn Asn Ser 
        35                  40                  45              

Ser Ser Ser Gln Thr Asn Ile Leu Ala Gln Leu Met Asp Phe Phe Thr 
    50                  55                  60                  

Gly Asn Gly His Leu Glu Asp Leu Ser Lys Ile Ser Glu Pro Glu Ala 
65                  70                  75                  80  

Leu Tyr Ala Tyr Ile Ala Glu Ala Thr Ala 
                85                  90  

<210>   2403
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2403
ttgttggaag aacgagaaat tgtcactcca acttatcgtg aagccttgat cacgcgtgaa   60
aagtcatttc caactggttt atatatggaa tttctaggaa aggacttgca aatg         114

<210>   2404
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Phosphotransferase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902606 (1.E-14)

<400>   2404
Met Leu Glu Glu Arg Glu Ile Val Thr Pro Thr Tyr Arg Glu Ala Leu 
1               5                   10                  15      

Ile Thr Arg Glu Lys Ser Phe Pro Thr Gly Leu Tyr Met Glu Phe Leu 
            20                  25                  30          

Gly Lys Asp Leu Gln Met 
        35              

<210>   2405
<211>   1884
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2405
atggtcttgt caaaatatca aaaacaattt ataataaata gataccctga aaggaagaga   60
atcatgaact tagaagaatt gaaaaaacga caggagaaga tccgtaactt ctctattatc   120
gcccatattg accacggaaa atcaactcta gcagaccgca ttttggaaaa aacagagacg   180
gtttcaagtc gtgaaatgca ggcccagctt ttggatagca tggagctaga gcgggaacgt   240
ggaattacta ttaagttgaa tgccatcgag ttgaattaca ctgcaaaaga tggggaaact   300
tatattttcc acttgattga cacaccaggg cacgttgact ttacctatga agtttcacgt   360
tcgctagctg cctgtgaggg tgctattttg gtggtcgatg cggctcaagg aattgaggct   420
caaactcttg ccaacgttta tctggctttg gataatgatt tggaaatcat gcctatcatt   480
aataaaattg acctgccggc tgcagatccg gagcgcgtgc gtacagagat tgaagatgtg   540
attggtttgg atgccagtga agcagttttg gcttctgcca aggctggtat tgggattgaa   600
gaaatcctcg agcaaattgt agaaaaagta ccagcaccaa cgggtgatgt gacggcgcca   660
cttaaggcct tgattttcga ctctgtttac gatgcttacc gtggggttat cctccaagtg   720
cgtgtcatgg acggagtggt caaacctggt gataagattc agctcatgag caatagtaag   780
acctttgatg tggccgaagt cggtattttt acaccaaaag cggttggtcg tgatttcctt   840
gcgactggtg atgttggtta cattgcggcg tctatcaaga cggttcagga tactcgtgtg   900
ggtgataccg ttaccttggc aaccaatcct gcggcagaac cattacatgg ttataagcag   960
atgaatccta tggtctttgc gggtctctac ccaatcgaat caaacaagta caatgacctg   1020
cgtgaagcgc ttgaaaaatt gcaactgaat gatgctagtc ttcagtttga accagaaaca   1080
tctcaggcac ttggatttgg tttccgttgt ggatttcttg gacttctcca tatggatgtt   1140
atccaggaac gtttagagcg tgagttcaat attgacctca tcatgacagc tccgtctgtt   1200
atttacaaag ttaatttgac cgacggtgag tctatggatg tgtctaaccc atctgagttt   1260
ccagacccaa ctaagattgc gaccattgaa gagccttatg tcaaggcgca aatcatggta   1320
ccacaggagt tcgtcggagc agtaatggag ctagctcagc gtaagcgtgg ggactttgtg   1380
actatggact atattgatga taaccgtgtc aatgttatct atcaaattcc tcttgctgaa   1440
attgtctttg acttctttga taaacttaag tcttcgacac gtggttatgc aagctttgac   1500
tacgaattgt cagaatatcg cccatctaag ctggtgaaaa tggatattct tctcaatgga   1560
gataaggtgg atgccctcag ctttatcgtt cacaaggact ttgcctacga acgtgggaaa   1620
ctcatcgttg ataaactcaa gaaaatcatc cctcgccaac aatttgaagt tccaatccaa   1680
gcggctattg gacacaagat tgtcgctcgt actgatatca aggcccttcg taagaacgta   1740
cttgctaaat gttatggtgg tgacgtttct cgtaagcgta aactccttga aaaacaaaaa   1800
gctggtaaga aacgcatgaa atccatcgga tcagttgaag ttccgcaaga agccttcctc   1860

agcgtcttga gtatggatga agaa                                          1884

<210>   2406
<211>   628
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP-binding protein LepA (lepA)
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15903125 (0.E+01)

<400>   2406
Met Val Leu Ser Lys Tyr Gln Lys Gln Phe Ile Ile Asn Arg Tyr Pro 
1               5                   10                  15      

Glu Arg Lys Arg Ile Met Asn Leu Glu Glu Leu Lys Lys Arg Gln Glu 
            20                  25                  30          

Lys Ile Arg Asn Phe Ser Ile Ile Ala His Ile Asp His Gly Lys Ser 
        35                  40                  45              

Thr Leu Ala Asp Arg Ile Leu Glu Lys Thr Glu Thr Val Ser Ser Arg 
    50                  55                  60                  

Glu Met Gln Ala Gln Leu Leu Asp Ser Met Glu Leu Glu Arg Glu Arg 
65                  70                  75                  80  

Gly Ile Thr Ile Lys Leu Asn Ala Ile Glu Leu Asn Tyr Thr Ala Lys 
                85                  90                  95      

Asp Gly Glu Thr Tyr Ile Phe His Leu Ile Asp Thr Pro Gly His Val 
            100                 105                 110         

Asp Phe Thr Tyr Glu Val Ser Arg Ser Leu Ala Ala Cys Glu Gly Ala 
        115                 120                 125             

Ile Leu Val Val Asp Ala Ala Gln Gly Ile Glu Ala Gln Thr Leu Ala 
    130                 135                 140                 

Asn Val Tyr Leu Ala Leu Asp Asn Asp Leu Glu Ile Met Pro Ile Ile 
145                 150                 155                 160 

Asn Lys Ile Asp Leu Pro Ala Ala Asp Pro Glu Arg Val Arg Thr Glu 
                165                 170                 175     

Ile Glu Asp Val Ile Gly Leu Asp Ala Ser Glu Ala Val Leu Ala Ser 
            180                 185                 190         

Ala Lys Ala Gly Ile Gly Ile Glu Glu Ile Leu Glu Gln Ile Val Glu 
        195                 200                 205             

Lys Val Pro Ala Pro Thr Gly Asp Val Thr Ala Pro Leu Lys Ala Leu 
    210                 215                 220                 

Ile Phe Asp Ser Val Tyr Asp Ala Tyr Arg Gly Val Ile Leu Gln Val 
225                 230                 235                 240 

Arg Val Met Asp Gly Val Val Lys Pro Gly Asp Lys Ile Gln Leu Met 
                245                 250                 255     

Ser Asn Ser Lys Thr Phe Asp Val Ala Glu Val Gly Ile Phe Thr Pro 
            260                 265                 270         

Lys Ala Val Gly Arg Asp Phe Leu Ala Thr Gly Asp Val Gly Tyr Ile 

        275                 280                 285             

Ala Ala Ser Ile Lys Thr Val Gln Asp Thr Arg Val Gly Asp Thr Val 
    290                 295                 300                 

Thr Leu Ala Thr Asn Pro Ala Ala Glu Pro Leu His Gly Tyr Lys Gln 
305                 310                 315                 320 

Met Asn Pro Met Val Phe Ala Gly Leu Tyr Pro Ile Glu Ser Asn Lys 
                325                 330                 335     

Tyr Asn Asp Leu Arg Glu Ala Leu Glu Lys Leu Gln Leu Asn Asp Ala 
            340                 345                 350         

Ser Leu Gln Phe Glu Pro Glu Thr Ser Gln Ala Leu Gly Phe Gly Phe 
        355                 360                 365             

Arg Cys Gly Phe Leu Gly Leu Leu His Met Asp Val Ile Gln Glu Arg 
    370                 375                 380                 

Leu Glu Arg Glu Phe Asn Ile Asp Leu Ile Met Thr Ala Pro Ser Val 
385                 390                 395                 400 

Ile Tyr Lys Val Asn Leu Thr Asp Gly Glu Ser Met Asp Val Ser Asn 
                405                 410                 415     

Pro Ser Glu Phe Pro Asp Pro Thr Lys Ile Ala Thr Ile Glu Glu Pro 
            420                 425                 430         

Tyr Val Lys Ala Gln Ile Met Val Pro Gln Glu Phe Val Gly Ala Val 
        435                 440                 445             

Met Glu Leu Ala Gln Arg Lys Arg Gly Asp Phe Val Thr Met Asp Tyr 
    450                 455                 460                 

Ile Asp Asp Asn Arg Val Asn Val Ile Tyr Gln Ile Pro Leu Ala Glu 
465                 470                 475                 480 

Ile Val Phe Asp Phe Phe Asp Lys Leu Lys Ser Ser Thr Arg Gly Tyr 
                485                 490                 495     

Ala Ser Phe Asp Tyr Glu Leu Ser Glu Tyr Arg Pro Ser Lys Leu Val 
            500                 505                 510         

Lys Met Asp Ile Leu Leu Asn Gly Asp Lys Val Asp Ala Leu Ser Phe 
        515                 520                 525             

Ile Val His Lys Asp Phe Ala Tyr Glu Arg Gly Lys Leu Ile Val Asp 
    530                 535                 540                 

Lys Leu Lys Lys Ile Ile Pro Arg Gln Gln Phe Glu Val Pro Ile Gln 
545                 550                 555                 560 

Ala Ala Ile Gly His Lys Ile Val Ala Arg Thr Asp Ile Lys Ala Leu 
                565                 570                 575     

Arg Lys Asn Val Leu Ala Lys Cys Tyr Gly Gly Asp Val Ser Arg Lys 
            580                 585                 590         

Arg Lys Leu Leu Glu Lys Gln Lys Ala Gly Lys Lys Arg Met Lys Ser 
        595                 600                 605             

Ile Gly Ser Val Glu Val Pro Gln Glu Ala Phe Leu Ser Val Leu Ser 
    610                 615                 620                 

Met Asp Glu Glu 
625             

<210>   2407
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2407
ttggacgact ggcatgaaac aacagattat aaaaaagtat ggcttagaaa accattccac   60
ggagctgaaa atcatactgg aaaaaccatt gtcttcggtc atacaccggt ctatggtttg   120
ttacagcaag aacgcggtac atctgagctt tggactacag aagatggcaa gattggaatg   180
gatggaggag ctgtttatgg tggtgtcctt cacgggattg tctttacaga ccaaggaatg   240
acagaacacc actttatcga aaatgacggc tttgtcgctg aagat                   285

<210>   2408
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   serine/threonine protein phosphatase

<400>   2408
Met Asp Asp Trp His Glu Thr Thr Asp Tyr Lys Lys Val Trp Leu Arg 
1               5                   10                  15      

Lys Pro Phe His Gly Ala Glu Asn His Thr Gly Lys Thr Ile Val Phe 
            20                  25                  30          

Gly His Thr Pro Val Tyr Gly Leu Leu Gln Gln Glu Arg Gly Thr Ser 
        35                  40                  45              

Glu Leu Trp Thr Thr Glu Asp Gly Lys Ile Gly Met Asp Gly Gly Ala 
    50                  55                  60                  

Val Tyr Gly Gly Val Leu His Gly Ile Val Phe Thr Asp Gln Gly Met 
65                  70                  75                  80  

Thr Glu His His Phe Ile Glu Asn Asp Gly Phe Val Ala Glu Asp 
                85                  90                  95  

<210>   2409
<211>   390
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2409
atgacagatt attatgtaat tggagatgtt cacggaaaag ctgggatgct ggaagacctt   60
ctcaaaacct gggatggtca gccccagttg ctctttctag gtgatttgat tgacagaggt   120
gaggatagtc accgtgttct tgaaatggtc aaggacttgg tggacaatca aggggctatc   180
tgtttgtccg gaaaccacga gtatatgttt ttgacttggc tagatgaccc agaagaaagt   240
tatgaccatt atagtcgcaa tggtggagat acaaccatta actctatcct aggtcgtccc   300
ttggatgcac cagttgatgg agtagaagat gccaagcggg ttgcgctgaa gcggcagact   360
tggtcgaatt cattcgtcaa atgccatttg                                    390

<210>   2410
<211>   130
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   serine/threonine protein phosphatase FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903126 (e-144)

<400>   2410
Met Thr Asp Tyr Tyr Val Ile Gly Asp Val His Gly Lys Ala Gly Met 
1               5                   10                  15      

Leu Glu Asp Leu Leu Lys Thr Trp Asp Gly Gln Pro Gln Leu Leu Phe 
            20                  25                  30          

Leu Gly Asp Leu Ile Asp Arg Gly Glu Asp Ser His Arg Val Leu Glu 
        35                  40                  45              

Met Val Lys Asp Leu Val Asp Asn Gln Gly Ala Ile Cys Leu Ser Gly 
    50                  55                  60                  

Asn His Glu Tyr Met Phe Leu Thr Trp Leu Asp Asp Pro Glu Glu Ser 
65                  70                  75                  80  

Tyr Asp His Tyr Ser Arg Asn Gly Gly Asp Thr Thr Ile Asn Ser Ile 
                85                  90                  95      

Leu Gly Arg Pro Leu Asp Ala Pro Val Asp Gly Val Glu Asp Ala Lys 
            100                 105                 110         

Arg Val Ala Leu Lys Arg Gln Thr Trp Ser Asn Ser Phe Val Lys Cys 
        115                 120                 125             


His Leu 
    130 

<210>   2411
<211>   1665
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2411
atgttacttg aaatttcgat aaaaaacttt gccattattg aggctatttc cctcaatttt   60
gaaaagggga tgactgtcct gactggtgaa acgggtgcag ggaagtcgat tatcattgat   120
gccatgaata tgatgttggg agctcgtgcg acgacagatg ttattcgtca tggtgcacca   180
aaggcagaga ttgaggggct tttctcagtt gagaatagtc gtcttttaca ggaaattttt   240
gatgagcaag gtttagaatt aggtgatgaa attatcatcc gtcgggaaat cttgcaaaat   300
ggtcgtagta tcagccgtgt aaatggtcag atggttaatc tgtctgtttt gcgagctatt   360
gggcaacatc ttgtagatat tcatggtcag catgaccatg aggagttaat gcgtccccaa   420
ctgcatatcc agatgttgga tgaatttggt gatgccgctt tttgggactt gaaagaaacc   480
tatcaaacga gttttgatgc ctatcggaaa atgcgcaagc aggttctgga agtcaagaaa   540
aaccaacagg aacacaaggc acgtatcgaa atgttggaat ttcaaatggc agagattgag   600
gcagcaaact tgcaggctgg agaagacttg gctctcaatc aagagcgaga taaactcctc   660
aaccacaaaa atattgcgga tacactgacc aatgcctaca gtatgttgga caatgaagat   720
ttttcaagtc tggccaatgt tcgttcagct atgaatgaca tggaaagtgt cgaagagtat   780
gatcctgaat accgtgaaat ttcaagctat ctgtctgaga cctactatgt tttagaagac   840
attagcaaac gtttggaagc tatcattgag gaccttgatt ttgatggcaa tcgcctgatg   900
caggttgaga atcgtttgga cctccttcat actattactc gtaagtatgg tgggactgtt   960
gatgatgttt tgctttattt tgccaagatt acggaagaat acaatctctt gacaggcaat   1020
aatctttcgt ctgaggacat ggaagcagag cttaagaagt tggaagtcaa tcttgtcaat   1080
ttggcaggtc aacttgcttc tgctcgtcat aatttggctc agcaactcga agctgagatt   1140
aaacaagaac tgcaagatct ttatatggaa aaagcccagt ttcaggttcg ttttagtaag   1200
ggaaaattca gtcgtgaggg aaataaaatg gttgagtttt atatttcaac caaccctgga   1260
gaagacttta aacccttggt taaggttgct tctggagggg aattatctcg tctcatgtta   1320
gccattaagt ctgccttttc acgtaaagaa ggcaagacta gcattgtctt tgatgaggtg   1380
gatacgggag tttcaggtcg tgttgctcaa gctattgctc agaaaattca taaaattggt   1440
cagcatggtc aggttttggc tatctcccat ttgccacaag taattgcgat tgcagattat   1500
caattcttta ttgagaagat tagtaatgac cattcaacgg tttcgactgt tcgtctcttg   1560
acggtcgaag agcgagtgga ggaagttgcc aagatgttgg caggtgatga tgtgacagaa   1620
gcagccctga cgcaagcaag agaattgttg agaaacaggg agaaa                   1665

<210>   2412
<211>   555
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA repair protein RecN (recN)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903127 (0.E+01)

<400>   2412
Met Leu Leu Glu Ile Ser Ile Lys Asn Phe Ala Ile Ile Glu Ala Ile 
1               5                   10                  15      

Ser Leu Asn Phe Glu Lys Gly Met Thr Val Leu Thr Gly Glu Thr Gly 
            20                  25                  30          

Ala Gly Lys Ser Ile Ile Ile Asp Ala Met Asn Met Met Leu Gly Ala 
        35                  40                  45              

Arg Ala Thr Thr Asp Val Ile Arg His Gly Ala Pro Lys Ala Glu Ile 
    50                  55                  60                  

Glu Gly Leu Phe Ser Val Glu Asn Ser Arg Leu Leu Gln Glu Ile Phe 
65                  70                  75                  80  

Asp Glu Gln Gly Leu Glu Leu Gly Asp Glu Ile Ile Ile Arg Arg Glu 
                85                  90                  95      

Ile Leu Gln Asn Gly Arg Ser Ile Ser Arg Val Asn Gly Gln Met Val 
            100                 105                 110         

Asn Leu Ser Val Leu Arg Ala Ile Gly Gln His Leu Val Asp Ile His 
        115                 120                 125             

Gly Gln His Asp His Glu Glu Leu Met Arg Pro Gln Leu His Ile Gln 
    130                 135                 140                 

Met Leu Asp Glu Phe Gly Asp Ala Ala Phe Trp Asp Leu Lys Glu Thr 
145                 150                 155                 160 

Tyr Gln Thr Ser Phe Asp Ala Tyr Arg Lys Met Arg Lys Gln Val Leu 
                165                 170                 175     

Glu Val Lys Lys Asn Gln Gln Glu His Lys Ala Arg Ile Glu Met Leu 
            180                 185                 190         

Glu Phe Gln Met Ala Glu Ile Glu Ala Ala Asn Leu Gln Ala Gly Glu 
        195                 200                 205             

Asp Leu Ala Leu Asn Gln Glu Arg Asp Lys Leu Leu Asn His Lys Asn 
    210                 215                 220                 

Ile Ala Asp Thr Leu Thr Asn Ala Tyr Ser Met Leu Asp Asn Glu Asp 
225                 230                 235                 240 

Phe Ser Ser Leu Ala Asn Val Arg Ser Ala Met Asn Asp Met Glu Ser 
                245                 250                 255     

Val Glu Glu Tyr Asp Pro Glu Tyr Arg Glu Ile Ser Ser Tyr Leu Ser 
            260                 265                 270         

Glu Thr Tyr Tyr Val Leu Glu Asp Ile Ser Lys Arg Leu Glu Ala Ile 
        275                 280                 285             

Ile Glu Asp Leu Asp Phe Asp Gly Asn Arg Leu Met Gln Val Glu Asn 
    290                 295                 300                 

Arg Leu Asp Leu Leu His Thr Ile Thr Arg Lys Tyr Gly Gly Thr Val 
305                 310                 315                 320 

Asp Asp Val Leu Leu Tyr Phe Ala Lys Ile Thr Glu Glu Tyr Asn Leu 
                325                 330                 335     

Leu Thr Gly Asn Asn Leu Ser Ser Glu Asp Met Glu Ala Glu Leu Lys 
            340                 345                 350         

Lys Leu Glu Val Asn Leu Val Asn Leu Ala Gly Gln Leu Ala Ser Ala 
        355                 360                 365             

Arg His Asn Leu Ala Gln Gln Leu Glu Ala Glu Ile Lys Gln Glu Leu 
    370                 375                 380                 

Gln Asp Leu Tyr Met Glu Lys Ala Gln Phe Gln Val Arg Phe Ser Lys 
385                 390                 395                 400 

Gly Lys Phe Ser Arg Glu Gly Asn Lys Met Val Glu Phe Tyr Ile Ser 
                405                 410                 415     

Thr Asn Pro Gly Glu Asp Phe Lys Pro Leu Val Lys Val Ala Ser Gly 
            420                 425                 430         

Gly Glu Leu Ser Arg Leu Met Leu Ala Ile Lys Ser Ala Phe Ser Arg 
        435                 440                 445             

Lys Glu Gly Lys Thr Ser Ile Val Phe Asp Glu Val Asp Thr Gly Val 
    450                 455                 460                 

Ser Gly Arg Val Ala Gln Ala Ile Ala Gln Lys Ile His Lys Ile Gly 
465                 470                 475                 480 

Gln His Gly Gln Val Leu Ala Ile Ser His Leu Pro Gln Val Ile Ala 
                485                 490                 495     

Ile Ala Asp Tyr Gln Phe Phe Ile Glu Lys Ile Ser Asn Asp His Ser 
            500                 505                 510         

Thr Val Ser Thr Val Arg Leu Leu Thr Val Glu Glu Arg Val Glu Glu 
        515                 520                 525             

Val Ala Lys Met Leu Ala Gly Asp Asp Val Thr Glu Ala Ala Leu Thr 
    530                 535                 540                 

Gln Ala Arg Glu Leu Leu Arg Asn Arg Glu Lys 
545                 550                 555 

<210>   2413
<211>   429
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2413
atgaataaaa aagagagact tgaaaaaatt agaagattgg tgacagatta tcaaatcggc   60
acgcaagaag aaattgtaga acatttgaaa gaagcaggta tcactgccac tcaggcgacg   120
gtatcccgag atatcaaaga gttaggtatt gtcaaaattc ctttgagaga caacacctat   180
gtctacgaat tgccaaaatc aatcgtaaaa agtctgcaac tggctgaaga caatatcgaa   240
tcggctgaat tgatggataa gatgatcaat ctccaagtta ttccaggaaa tacggctttt   300
gtaaaagctc agttaatcga gacttttgca gacaagattt ttagctgttt gactgatgat   360
agctcgattt tagtcattgc cagaagtgga agtctagcag aggaaatctt tgaacaagta   420
aaaaattgg                                                           429

<210>   2414
<211>   143
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional repressor, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903128 (1.E-75)

<400>   2414
Met Asn Lys Lys Glu Arg Leu Glu Lys Ile Arg Arg Leu Val Thr Asp 
1               5                   10                  15      

Tyr Gln Ile Gly Thr Gln Glu Glu Ile Val Glu His Leu Lys Glu Ala 
            20                  25                  30          

Gly Ile Thr Ala Thr Gln Ala Thr Val Ser Arg Asp Ile Lys Glu Leu 
        35                  40                  45              

Gly Ile Val Lys Ile Pro Leu Arg Asp Asn Thr Tyr Val Tyr Glu Leu 
    50                  55                  60                  

Pro Lys Ser Ile Val Lys Ser Leu Gln Leu Ala Glu Asp Asn Ile Glu 
65                  70                  75                  80  


Ser Ala Glu Leu Met Asp Lys Met Ile Asn Leu Gln Val Ile Pro Gly 
                85                  90                  95      

Asn Thr Ala Phe Val Lys Ala Gln Leu Ile Glu Thr Phe Ala Asp Lys 
            100                 105                 110         

Ile Phe Ser Cys Leu Thr Asp Asp Ser Ser Ile Leu Val Ile Ala Arg 
        115                 120                 125             

Ser Gly Ser Leu Ala Glu Glu Ile Phe Glu Gln Val Lys Asn Trp 
    130                 135                 140             

<210>   2415
<211>   594
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2415
ttgcaggtct ttgatttgtc ggtggatggc gcgactacga ttgatatcgg ggcctctact   60
ggaggtttta ccgatgtcat gctacagaat agtgccaagt tggtctttgc agtcgatgtt   120
ggtaccaatc agttggcttg gaaattacgc caagacccac gagttgtcag catggagcag   180
ttcaatttcc gctatgctga aaagactgat ttcgagcagg agccgagctt tgccagtatt   240
gatgtgagtt tcatttccct tagtctgatt ttgccagcct tgcaccgtgt cttggctgat   300
caaggtcagg tggtagcact tgtcaaacct cagtttgagg caggacgtga gcagattggg   360
aaaaatggaa ttattcgaga tgctaaggtt catcagaatg tccttgaatc tgtaacagct   420
atggcagtag aggtaggttt ttcagtcctt ggcttggact tttctcccat ccaaggtgga   480
catggaaata ttgaattttt agcgtatttg aaaaaagaaa agtcagcaag caatcagatt   540
cttgctgaga ttaaagaagc agtagagagg gcgcatagtc aatttaaaaa tgaa         594

<210>   2416
<211>   198
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hemolysin A, putative, FRAMESHIFT
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903129 (e-106)

<400>   2416
Met Gln Val Phe Asp Leu Ser Val Asp Gly Ala Thr Thr Ile Asp Ile 
1               5                   10                  15      

Gly Ala Ser Thr Gly Gly Phe Thr Asp Val Met Leu Gln Asn Ser Ala 
            20                  25                  30          

Lys Leu Val Phe Ala Val Asp Val Gly Thr Asn Gln Leu Ala Trp Lys 
        35                  40                  45              

Leu Arg Gln Asp Pro Arg Val Val Ser Met Glu Gln Phe Asn Phe Arg 
    50                  55                  60                  

Tyr Ala Glu Lys Thr Asp Phe Glu Gln Glu Pro Ser Phe Ala Ser Ile 
65                  70                  75                  80  

Asp Val Ser Phe Ile Ser Leu Ser Leu Ile Leu Pro Ala Leu His Arg 
                85                  90                  95      

Val Leu Ala Asp Gln Gly Gln Val Val Ala Leu Val Lys Pro Gln Phe 
            100                 105                 110         

Glu Ala Gly Arg Glu Gln Ile Gly Lys Asn Gly Ile Ile Arg Asp Ala 
        115                 120                 125             

Lys Val His Gln Asn Val Leu Glu Ser Val Thr Ala Met Ala Val Glu 
    130                 135                 140                 

Val Gly Phe Ser Val Leu Gly Leu Asp Phe Ser Pro Ile Gln Gly Gly 
145                 150                 155                 160 

His Gly Asn Ile Glu Phe Leu Ala Tyr Leu Lys Lys Glu Lys Ser Ala 
                165                 170                 175     

Ser Asn Gln Ile Leu Ala Glu Ile Lys Glu Ala Val Glu Arg Ala His 
            180                 185                 190         

Ser Gln Phe Lys Asn Glu 
        195             

<210>   2417
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2417
atgaaaaagc aagaaaaatt agctcttgtc gagtcggctt tggaagattt ttatggagac   60
cagcagtttg cctctagttt acgggagtct gttctctatt ctattcatgc tggtggcaag   120
cgtattcggc cttttctctt gttagaagtt ctggaagcct tgcaggttac catcaaacct   180
gctcacgcgc aggtagctac tgccttagag atgattcata cagggagctt gattcacgat   240
gaccttcctg ctatggatga tgacgattat cgaagagggc ggttaaccaa tcacaagaaa   300
ttcggtgaag ctatggccat tttggctgga gatgccttat tcttagactc atatgccttg   360
attgcgcagg cagatttgcc aagtcagatt aaggtggact tgattgccaa cttatccctt   420
gcttcaggta gtctgggtat ggtagcaggg caagttttgg atatggaggg cgaacaccag   480
cacttgtctt tggaagaact tcagactatt catgccaata agactgggaa gttactagcc   540
tatcccttcc aagcggcagc tattatagct gaattgtcac ctgaaatgca ggtgaagctg   600
aaaactgtgg gtgaattgat tggacttgct tttcaagtca gagatgatgt actggatgtg   660
acagctagtt ttgaggaaat cggcaagaca cctcaaaagg atctgcaggc agaaaaatca   720
acctatcctg ccctgttggg cttggaagag tccattgcct tttgtaacca aaccctggat   780
caagctaatg aaaaattaga agaaattgcc cagcagcttc cctttgaaac agaatcgatt   840
gtaagtgtag tagaaagttt gagaatcaat ggc                                873

<210>   2418
<211>   291
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   geranyltranstransferase (ispA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903130 (e-159)

<400>   2418
Met Lys Lys Gln Glu Lys Leu Ala Leu Val Glu Ser Ala Leu Glu Asp 
1               5                   10                  15      

Phe Tyr Gly Asp Gln Gln Phe Ala Ser Ser Leu Arg Glu Ser Val Leu 
            20                  25                  30          

Tyr Ser Ile His Ala Gly Gly Lys Arg Ile Arg Pro Phe Leu Leu Leu 
        35                  40                  45              

Glu Val Leu Glu Ala Leu Gln Val Thr Ile Lys Pro Ala His Ala Gln 
    50                  55                  60                  

Val Ala Thr Ala Leu Glu Met Ile His Thr Gly Ser Leu Ile His Asp 
65                  70                  75                  80  

Asp Leu Pro Ala Met Asp Asp Asp Asp Tyr Arg Arg Gly Arg Leu Thr 
                85                  90                  95      

Asn His Lys Lys Phe Gly Glu Ala Met Ala Ile Leu Ala Gly Asp Ala 
            100                 105                 110         

Leu Phe Leu Asp Ser Tyr Ala Leu Ile Ala Gln Ala Asp Leu Pro Ser 
        115                 120                 125             

Gln Ile Lys Val Asp Leu Ile Ala Asn Leu Ser Leu Ala Ser Gly Ser 
    130                 135                 140                 

Leu Gly Met Val Ala Gly Gln Val Leu Asp Met Glu Gly Glu His Gln 
145                 150                 155                 160 

His Leu Ser Leu Glu Glu Leu Gln Thr Ile His Ala Asn Lys Thr Gly 
                165                 170                 175     

Lys Leu Leu Ala Tyr Pro Phe Gln Ala Ala Ala Ile Ile Ala Glu Leu 
            180                 185                 190         

Ser Pro Glu Met Gln Val Lys Leu Lys Thr Val Gly Glu Leu Ile Gly 
        195                 200                 205             

Leu Ala Phe Gln Val Arg Asp Asp Val Leu Asp Val Thr Ala Ser Phe 
    210                 215                 220                 

Glu Glu Ile Gly Lys Thr Pro Gln Lys Asp Leu Gln Ala Glu Lys Ser 
225                 230                 235                 240 

Thr Tyr Pro Ala Leu Leu Gly Leu Glu Glu Ser Ile Ala Phe Cys Asn 
                245                 250                 255     

Gln Thr Leu Asp Gln Ala Asn Glu Lys Leu Glu Glu Ile Ala Gln Gln 
            260                 265                 270         

Leu Pro Phe Glu Thr Glu Ser Ile Val Ser Val Val Glu Ser Leu Arg 
        275                 280                 285             

Ile Asn Gly 
    290     

<210>   2419
<211>   210
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2419
atgtcaaaac aaaagaaatt tgaggaaaat ctagcagaac tggaaaccat tgtccaaagt   60
ttggaaaatg gtgaaattgc tctggaagat gcgattactg cctttcaaaa gggcatggtc   120
ttgtcaaaag agctccaagc tacgctggac aaggctgaaa agaccttggt caaggtcatg   180
caagaagacg gaacagaaag tgattttgaa                                    210

<210>   2420
<211>   70
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   exodeoxyribonuclease VII, small subunit (xseB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903131 (4.E-34)

<400>   2420
Met Ser Lys Gln Lys Lys Phe Glu Glu Asn Leu Ala Glu Leu Glu Thr 
1               5                   10                  15      

Ile Val Gln Ser Leu Glu Asn Gly Glu Ile Ala Leu Glu Asp Ala Ile 
            20                  25                  30          

Thr Ala Phe Gln Lys Gly Met Val Leu Ser Lys Glu Leu Gln Ala Thr 
        35                  40                  45              

Leu Asp Lys Ala Glu Lys Thr Leu Val Lys Val Met Gln Glu Asp Gly 
    50                  55                  60                  

Thr Glu Ser Asp Phe Glu 
65                  70  

<210>   2421
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2421
gtggagatgg aaaagtattt atcggtaaca actttgacca agtatctgaa aatgaaattc   60
gataaagacc catacttgga acgggtctat ttaactggtc aagtttccaa ctttcgtaaa   120
cgacctactc accaatattt ctccctaaag gatgaccatg cagttattca agcgaccatc   180
tggtctggga tttatcagaa attagggttt gacctggaag aaggaatgaa gatcaatgtg   240
attgggcgtg tacaggtcta tgaaccaagt ggtagctact ccatcatcat tgaaaaagct   300
gagcctgatg gggttggggc gcttgcgatt cagtttgaac aacttaagaa aaaattgaca   360
gaagaaggcc tgtttcaaga acgcttcaag caagctctgc cccaattttc taagagaatt   420
ggtgtagtaa ccagccgtag tggagccgtt attcgagata ttatcacgac cgtcagcagg   480
cgattcccag gtgttgacat ccttctttat ccgaccaagg ttcaaggtga aggggctgcg   540
gaggaaattg ctagaaatat tgcgcgtgct aatcaacggg acgatttgga tttgctcatt   600
attggtcgtg gaggtggttc tattgaggat ctctgggcct ttaacgaaga aattgtggta   660
cgagctattt ttgaatctcg tttgccagtt atctctagtg tggggcatga gacggatgtg   720
accttggcag attttgtggc agatcgacgc gctgcaacgc caacagcggc ggctgaactg   780
gcaacacctg tgaccaagtt ggatgtatta gctcatttgc aaaatcagga aaaacggatg   840
gtaacggcag tccgaaatgt tctatctaag aaacaagagg ctttgaaaaa atgcagtcag   900
tctgttatct ttagacaacc tgagcgcttg tatgacggtt atttgcaacg cttggaccaa   960
ctgcaactgc gtttgaaaca aagtttgcga actcggattt ctgataacaa acaattagtt   1020
caagcaagaa ctcatcaatt agtacaatta tcacctgtta ccaaaatcca acgctatcaa   1080
gaccgtttag gacagttgga caagctctta ggtagccaaa tggcgttagt ttatgacgcc   1140
aaggttgctg aggccaagcg actttcggaa gctttgctca tgttggatac tagccgaatc   1200
gtggcgcgtg gttatgctat tgtcaaaaaa gaagagtccg ttgtagattc ggttgagagt   1260
ttgaagaaaa aagaccaagt aacgcttttg atgcgagatg gtcaagtaga attagaggtt   1320
aaagatgtca aaacaaaaga aatt                                          1344

<210>   2422
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   exodeoxyribonuclease VII, large subunit (xseA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903132 (0.E+01)

<400>   2422
Met Glu Met Glu Lys Tyr Leu Ser Val Thr Thr Leu Thr Lys Tyr Leu 
1               5                   10                  15      

Lys Met Lys Phe Asp Lys Asp Pro Tyr Leu Glu Arg Val Tyr Leu Thr 
            20                  25                  30          

Gly Gln Val Ser Asn Phe Arg Lys Arg Pro Thr His Gln Tyr Phe Ser 
        35                  40                  45              

Leu Lys Asp Asp His Ala Val Ile Gln Ala Thr Ile Trp Ser Gly Ile 
    50                  55                  60                  

Tyr Gln Lys Leu Gly Phe Asp Leu Glu Glu Gly Met Lys Ile Asn Val 
65                  70                  75                  80  

Ile Gly Arg Val Gln Val Tyr Glu Pro Ser Gly Ser Tyr Ser Ile Ile 
                85                  90                  95      

Ile Glu Lys Ala Glu Pro Asp Gly Val Gly Ala Leu Ala Ile Gln Phe 
            100                 105                 110         

Glu Gln Leu Lys Lys Lys Leu Thr Glu Glu Gly Leu Phe Gln Glu Arg 
        115                 120                 125             

Phe Lys Gln Ala Leu Pro Gln Phe Ser Lys Arg Ile Gly Val Val Thr 
    130                 135                 140                 

Ser Arg Ser Gly Ala Val Ile Arg Asp Ile Ile Thr Thr Val Ser Arg 
145                 150                 155                 160 

Arg Phe Pro Gly Val Asp Ile Leu Leu Tyr Pro Thr Lys Val Gln Gly 
                165                 170                 175     

Glu Gly Ala Ala Glu Glu Ile Ala Arg Asn Ile Ala Arg Ala Asn Gln 
            180                 185                 190         

Arg Asp Asp Leu Asp Leu Leu Ile Ile Gly Arg Gly Gly Gly Ser Ile 
        195                 200                 205             

Glu Asp Leu Trp Ala Phe Asn Glu Glu Ile Val Val Arg Ala Ile Phe 
    210                 215                 220                 

Glu Ser Arg Leu Pro Val Ile Ser Ser Val Gly His Glu Thr Asp Val 
225                 230                 235                 240 

Thr Leu Ala Asp Phe Val Ala Asp Arg Arg Ala Ala Thr Pro Thr Ala 
                245                 250                 255     

Ala Ala Glu Leu Ala Thr Pro Val Thr Lys Leu Asp Val Leu Ala His 
            260                 265                 270         

Leu Gln Asn Gln Glu Lys Arg Met Val Thr Ala Val Arg Asn Val Leu 
        275                 280                 285             

Ser Lys Lys Gln Glu Ala Leu Lys Lys Cys Ser Gln Ser Val Ile Phe 
    290                 295                 300                 

Arg Gln Pro Glu Arg Leu Tyr Asp Gly Tyr Leu Gln Arg Leu Asp Gln 
305                 310                 315                 320 

Leu Gln Leu Arg Leu Lys Gln Ser Leu Arg Thr Arg Ile Ser Asp Asn 
                325                 330                 335     

Lys Gln Leu Val Gln Ala Arg Thr His Gln Leu Val Gln Leu Ser Pro 
            340                 345                 350         

Val Thr Lys Ile Gln Arg Tyr Gln Asp Arg Leu Gly Gln Leu Asp Lys 
        355                 360                 365             

Leu Leu Gly Ser Gln Met Ala Leu Val Tyr Asp Ala Lys Val Ala Glu 
    370                 375                 380                 

Ala Lys Arg Leu Ser Glu Ala Leu Leu Met Leu Asp Thr Ser Arg Ile 
385                 390                 395                 400 

Val Ala Arg Gly Tyr Ala Ile Val Lys Lys Glu Glu Ser Val Val Asp 
                405                 410                 415     

Ser Val Glu Ser Leu Lys Lys Lys Asp Gln Val Thr Leu Leu Met Arg 
            420                 425                 430         

Asp Gly Gln Val Glu Leu Glu Val Lys Asp Val Lys Thr Lys Glu Ile 
        435                 440                 445             


<210>   2423
<211>   636
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2423
atgcaaaata gaccaatcat tattggagtg acaggtggtt ctggtggtgg taaaaccagt   60
gtttcaagag ccattttatc gcattttcct gatgaaaaga tttccatgat tgagcatgat   120
tcatactaca aggatcagtc tcatttgacc tttgaagagc gtgtcaaaac caactatgac   180
catccttttg cctttgatac agacttgatg atcgagcaga ttaaggaatt gttggcaggg   240
cgtccggtgg acatcccgac ctacgactat acagagcata cacggagtag caagacctat   300
cgtcaggaac ctcaagatgt ctttatcgtt gagggtattt tggtcttgga ggacaagcgt   360
ctgcgcgatt tgatggatat caagattttt gtggatacgg atgacgatgt gcgcattatt   420

cgtcgtatca agcgtgatat ggaggagcgt ggccgtagcc ttgatagcgt tattaaccag   480
tacttaggtg tggtcaaacc aatgtaccac cagtttatcg agtcaactaa gcgttatgct   540
gatatcgtca ttcctgaagg ggttagcaat accgtggcta tcgacctgtt gacgaccaag   600
attgcaaaga ttttggaaga agctcgaaac agcaaa                             636

<210>   2424
<211>   212
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   uridine kinase (udk)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903133 (e-119)

<400>   2424
Met Gln Asn Arg Pro Ile Ile Ile Gly Val Thr Gly Gly Ser Gly Gly 
1               5                   10                  15      

Gly Lys Thr Ser Val Ser Arg Ala Ile Leu Ser His Phe Pro Asp Glu 
            20                  25                  30          

Lys Ile Ser Met Ile Glu His Asp Ser Tyr Tyr Lys Asp Gln Ser His 
        35                  40                  45              

Leu Thr Phe Glu Glu Arg Val Lys Thr Asn Tyr Asp His Pro Phe Ala 
    50                  55                  60                  

Phe Asp Thr Asp Leu Met Ile Glu Gln Ile Lys Glu Leu Leu Ala Gly 
65                  70                  75                  80  

Arg Pro Val Asp Ile Pro Thr Tyr Asp Tyr Thr Glu His Thr Arg Ser 
                85                  90                  95      

Ser Lys Thr Tyr Arg Gln Glu Pro Gln Asp Val Phe Ile Val Glu Gly 
            100                 105                 110         

Ile Leu Val Leu Glu Asp Lys Arg Leu Arg Asp Leu Met Asp Ile Lys 
        115                 120                 125             

Ile Phe Val Asp Thr Asp Asp Asp Val Arg Ile Ile Arg Arg Ile Lys 
    130                 135                 140                 

Arg Asp Met Glu Glu Arg Gly Arg Ser Leu Asp Ser Val Ile Asn Gln 
145                 150                 155                 160 

Tyr Leu Gly Val Val Lys Pro Met Tyr His Gln Phe Ile Glu Ser Thr 
                165                 170                 175     

Lys Arg Tyr Ala Asp Ile Val Ile Pro Glu Gly Val Ser Asn Thr Val 
            180                 185                 190         

Ala Ile Asp Leu Leu Thr Thr Lys Ile Ala Lys Ile Leu Glu Glu Ala 
        195                 200                 205             

Arg Asn Ser Lys 
    210         

<210>   2425
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2425
ttgcatgcta tcctccgtta ttttatccgt cgtctattct atcacatttt ttacaaaatt   60
tatagtctca tcagcaaaaa acaccagagt cttccctctg atgttcgaca gttt         114

<210>   2426
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2426
Met His Ala Ile Leu Arg Tyr Phe Ile Arg Arg Leu Phe Tyr His Ile 
1               5                   10                  15      

Phe Tyr Lys Ile Tyr Ser Leu Ile Ser Lys Lys His Gln Ser Leu Pro 
            20                  25                  30          

Ser Asp Val Arg Gln Phe 
        35              

<210>   2427
<211>   165
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2427
atggccaatt tgagtcaagg gttgtcactt tacctcatga cgcatcatta ccaggcacct   60
aagtctgtca ttgattttgg tttatggatt gccaaagctc ctagccagga aagagggaga   120
ctggctttct tgcagatgct tgctcaaacc ctacagggct ttcgt                   165

<210>   2428
<211>   55
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903134 (1.E-27)

<400>   2428

Met Ala Asn Leu Ser Gln Gly Leu Ser Leu Tyr Leu Met Thr His His 
1               5                   10                  15      

Tyr Gln Ala Pro Lys Ser Val Ile Asp Phe Gly Leu Trp Ile Ala Lys 
            20                  25                  30          

Ala Pro Ser Gln Glu Arg Gly Arg Leu Ala Phe Leu Gln Met Leu Ala 
        35                  40                  45              

Gln Thr Leu Gln Gly Phe Arg 
    50                  55  

<210>   2429
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2429
atgaagcaat ttaaaattct ttcagataaa tatttagagt ccattacagg ttctgatggg   60
aacttaggcc caggatttgg tgtgataatt cca                                93

<210>   2430
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2430
Met Lys Gln Phe Lys Ile Leu Ser Asp Lys Tyr Leu Glu Ser Ile Thr 
1               5                   10                  15      

Gly Ser Asp Gly Asn Leu Gly Pro Gly Phe Gly Val Ile Ile Pro 
            20                  25                  30      

<210>   2431
<211>   876
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2431
atgaacggta ttattaactt aaaaaaggaa gcaggaatga cctcgcatga tgcggttttt   60
aaactgcgta agattttggg aaccaagaaa attggtcatg gtggaacctt ggatccggat   120
gtggtgggtg ttttgccgat tgcggttggc aaggcgacac gcatggtcga gtttatgcag   180
gacgagggta agatctatga gggggaaatc actctgggct attccacgaa gactgaggat   240
gctagtgggg aagtggtcgc agaaacccct gttttgtctc tcttggatga aaagcttgtt   300
gatgaagcga ttgctagctt gactgggcct attactcaga ttccccctat gtattcggca   360
gttaaggtta atggtcgcaa gctctatgag tatgcgcgtg ctggtcagga agtggagcgt   420
ccagaacgtc aggtgaccat ttatcaattt gagcgaacaa gtccgatttc ttatgatggc   480
caacttgccc gattcacttt tcgtgtaaaa tgcagtaaag ggacgtacat ccgtactttg   540
tcagttgatt tgggtgaaaa gcttggttat gcggctcata tgtcccattt gactcgtact   600
agtgctgctg gcttacaatt agaagacgct cttgccttgg aggaaattgc tgaaaaagta   660
gaggctgggc aattagattt tctccatcct ttagagattg ggacaggtga ccttgtcaaa   720
gttttcctaa gtccagaaga ggctacagaa gttcgctttg gtcgttttat tgagctagac   780
caaacggaca aagaactggc tgcctttgaa gatgataaat tgttagccat tctagaaaaa   840
cggggcaatc tctataagcc aaggaaggtt tttagc                             876

<210>   2432
<211>   292
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tRNA pseudouridine synthase B (truB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903135 (e-161)

<400>   2432
Met Asn Gly Ile Ile Asn Leu Lys Lys Glu Ala Gly Met Thr Ser His 
1               5                   10                  15      

Asp Ala Val Phe Lys Leu Arg Lys Ile Leu Gly Thr Lys Lys Ile Gly 
            20                  25                  30          

His Gly Gly Thr Leu Asp Pro Asp Val Val Gly Val Leu Pro Ile Ala 
        35                  40                  45              

Val Gly Lys Ala Thr Arg Met Val Glu Phe Met Gln Asp Glu Gly Lys 
    50                  55                  60                  

Ile Tyr Glu Gly Glu Ile Thr Leu Gly Tyr Ser Thr Lys Thr Glu Asp 
65                  70                  75                  80  

Ala Ser Gly Glu Val Val Ala Glu Thr Pro Val Leu Ser Leu Leu Asp 
                85                  90                  95      

Glu Lys Leu Val Asp Glu Ala Ile Ala Ser Leu Thr Gly Pro Ile Thr 
            100                 105                 110         

Gln Ile Pro Pro Met Tyr Ser Ala Val Lys Val Asn Gly Arg Lys Leu 
        115                 120                 125             

Tyr Glu Tyr Ala Arg Ala Gly Gln Glu Val Glu Arg Pro Glu Arg Gln 
    130                 135                 140                 

Val Thr Ile Tyr Gln Phe Glu Arg Thr Ser Pro Ile Ser Tyr Asp Gly 
145                 150                 155                 160 

Gln Leu Ala Arg Phe Thr Phe Arg Val Lys Cys Ser Lys Gly Thr Tyr 
                165                 170                 175     

Ile Arg Thr Leu Ser Val Asp Leu Gly Glu Lys Leu Gly Tyr Ala Ala 
            180                 185                 190         

His Met Ser His Leu Thr Arg Thr Ser Ala Ala Gly Leu Gln Leu Glu 
        195                 200                 205             

Asp Ala Leu Ala Leu Glu Glu Ile Ala Glu Lys Val Glu Ala Gly Gln 
    210                 215                 220                 

Leu Asp Phe Leu His Pro Leu Glu Ile Gly Thr Gly Asp Leu Val Lys 
225                 230                 235                 240 

Val Phe Leu Ser Pro Glu Glu Ala Thr Glu Val Arg Phe Gly Arg Phe 
                245                 250                 255     

Ile Glu Leu Asp Gln Thr Asp Lys Glu Leu Ala Ala Phe Glu Asp Asp 
            260                 265                 270         

Lys Leu Leu Ala Ile Leu Glu Lys Arg Gly Asn Leu Tyr Lys Pro Arg 
        275                 280                 285             

Lys Val Phe Ser 
    290         

<210>   2433
<211>   1272
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2433
atgaacgaaa tcaaatgtcc caactgtggg gaagtcttta cagtaaatga gagtcagtat   60
gccgaactct tgtcccaagt gagaacggca gagtttgata aggaactaca cgataggatg   120
aagcaggaac tggccttggc tgagcaaaag gccatgaatg agcaacagac taaactggct   180
cagaaggatc aagaaattgc gcaattacag agtcagatcc aaaactttga tacagaaaaa   240
gaattggcca agaaagaggt tgaacagaca agccatgagg ctctcttggc taaggacaag   300
gaagtacagc tcttagaaaa tcagttggct accttgcgtt tggagcatga aaatcaacta   360
caaaagaccc tttctgacct agaaaaagaa cgggatcagg ttaaaaacca actacttttg   420
caggaaaagg aaaatgaatt atctttggct tctgttaagc aaaactacga agcccagctc   480
aaggcagcta gtgaacaagt cgagttttat aagaatttta aggctcaaca atctacaaaa   540
gcgattgggg aaagcctaga acagtatgca gagagtgagt ttaacaaggt tcgtagtttc   600
gcctttccaa atgcttactt tgagaaggat aacaaggtct cttcgcgtgg gtctaaaggg   660
gactttatct tccgtgagtg tgatgaaaat ggagttgaaa tcatttctat catgtttgag   720
atgaaaaacg aagcggacgg aacagagaag aagcacaaga atgcagattt ttacaaggaa   780
ttggacaagg accgtcggga gaagaactgt gagtatgccg ttttggtgac catgcttgag   840
gctgataatg actactttaa cacagggatt gttgacgtca gtcacgagta tgaaaaaatg   900
tatgttgttc gtcctcaatt ctttatccaa ttgattggtc tcttacgtaa tgcggcgcta   960
aattccctaa aatacaagca ggagttggcc ttggttcgcg agcaaaatat tgacattacg   1020
cattttgagg aagatttgga tgcctttaag ctagcttttg ctaagaacta taattcagct   1080
tcgactaact ttggaaaagc tattgatgaa atcgacaagg ccatcaaacg catggaagag   1140
gttaagaaat tcctgaccac atctgaaaac caactccgtt tagctaacaa caaattggaa   1200
gatgtctctg ttaaaaaatt gacccggaaa aatccaacaa tgaaagcgaa gttcgaagca   1260
ctgaaggggg ag                                                       1272

<210>   2434
<211>   424
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903137 (0.E+01)

<400>   2434
Met Asn Glu Ile Lys Cys Pro Asn Cys Gly Glu Val Phe Thr Val Asn 
1               5                   10                  15      

Glu Ser Gln Tyr Ala Glu Leu Leu Ser Gln Val Arg Thr Ala Glu Phe 
            20                  25                  30          

Asp Lys Glu Leu His Asp Arg Met Lys Gln Glu Leu Ala Leu Ala Glu 
        35                  40                  45              

Gln Lys Ala Met Asn Glu Gln Gln Thr Lys Leu Ala Gln Lys Asp Gln 
    50                  55                  60                  

Glu Ile Ala Gln Leu Gln Ser Gln Ile Gln Asn Phe Asp Thr Glu Lys 
65                  70                  75                  80  

Glu Leu Ala Lys Lys Glu Val Glu Gln Thr Ser His Glu Ala Leu Leu 
                85                  90                  95      

Ala Lys Asp Lys Glu Val Gln Leu Leu Glu Asn Gln Leu Ala Thr Leu 
            100                 105                 110         

Arg Leu Glu His Glu Asn Gln Leu Gln Lys Thr Leu Ser Asp Leu Glu 
        115                 120                 125             

Lys Glu Arg Asp Gln Val Lys Asn Gln Leu Leu Leu Gln Glu Lys Glu 
    130                 135                 140                 

Asn Glu Leu Ser Leu Ala Ser Val Lys Gln Asn Tyr Glu Ala Gln Leu 
145                 150                 155                 160 

Lys Ala Ala Ser Glu Gln Val Glu Phe Tyr Lys Asn Phe Lys Ala Gln 
                165                 170                 175     

Gln Ser Thr Lys Ala Ile Gly Glu Ser Leu Glu Gln Tyr Ala Glu Ser 
            180                 185                 190         

Glu Phe Asn Lys Val Arg Ser Phe Ala Phe Pro Asn Ala Tyr Phe Glu 
        195                 200                 205             

Lys Asp Asn Lys Val Ser Ser Arg Gly Ser Lys Gly Asp Phe Ile Phe 
    210                 215                 220                 

Arg Glu Cys Asp Glu Asn Gly Val Glu Ile Ile Ser Ile Met Phe Glu 
225                 230                 235                 240 

Met Lys Asn Glu Ala Asp Gly Thr Glu Lys Lys His Lys Asn Ala Asp 
                245                 250                 255     

Phe Tyr Lys Glu Leu Asp Lys Asp Arg Arg Glu Lys Asn Cys Glu Tyr 
            260                 265                 270         

Ala Val Leu Val Thr Met Leu Glu Ala Asp Asn Asp Tyr Phe Asn Thr 
        275                 280                 285             

Gly Ile Val Asp Val Ser His Glu Tyr Glu Lys Met Tyr Val Val Arg 
    290                 295                 300                 

Pro Gln Phe Phe Ile Gln Leu Ile Gly Leu Leu Arg Asn Ala Ala Leu 
305                 310                 315                 320 

Asn Ser Leu Lys Tyr Lys Gln Glu Leu Ala Leu Val Arg Glu Gln Asn 
                325                 330                 335     

Ile Asp Ile Thr His Phe Glu Glu Asp Leu Asp Ala Phe Lys Leu Ala 
            340                 345                 350         

Phe Ala Lys Asn Tyr Asn Ser Ala Ser Thr Asn Phe Gly Lys Ala Ile 
        355                 360                 365             

Asp Glu Ile Asp Lys Ala Ile Lys Arg Met Glu Glu Val Lys Lys Phe 
    370                 375                 380                 

Leu Thr Thr Ser Glu Asn Gln Leu Arg Leu Ala Asn Asn Lys Leu Glu 
385                 390                 395                 400 

Asp Val Ser Val Lys Lys Leu Thr Arg Lys Asn Pro Thr Met Lys Ala 
                405                 410                 415     

Lys Phe Glu Ala Leu Lys Gly Glu 
            420                 

<210>   2435
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2435
atgacttgtg attttaaatt tgaaactcta caactacatg ctggtcaagt tgtggctcca   60
gctactaagt ctcgtgcagt gccgatttat caaacaacat tttttgtttt tgatgacacg   120


<210>   2436
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transulfuration enzyme family protein, POINT MUTATION

<400>   2436
Met Thr Cys Asp Phe Lys Phe Glu Thr Leu Gln Leu His Ala Gly Gln 
1               5                   10                  15      

Val Val Ala Pro Ala Thr Lys Ser Arg Ala Val Pro Ile Tyr Gln Thr 
            20                  25                  30          

Thr Phe Phe Val Phe Asp Asp Thr 
        35                  40  

<210>   2437
<211>   795
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2437
atggtttctt cggaatttat ctcaaagatt gaatttgctt gcaataagaa agaaagtctt   60
tatagtcaaa gcaaatttaa gtatgcgatt cgttcgatgt tcgcaggtgc atttttaacc   120
ttcagtactg ctgcaggtgc agttggggct gacttgatta ataaaattgc accaggtagt   180
ggacgcttcc tctttccatt cgtttttgct tggggcttgg cctacattgt ttttttgaat   240
gccgagttgg tcacttcaaa catgatgttc ttgactgctg gtagtttctt aaaaaaaatc   300
tcttggagaa aaacagctga gattttacta tactgtacct tgttcaacct tatcggagcc   360
ttgatagcag ggtggggctt tgctcattcg gcagcctatg cgaatctgac acacgatagt   420
ttcatctcag gtgttgttga gatgaagtta ggccgctcaa atgaattggt cttgcttgag   480
gcgattttgg caaatatttt tgtaaatatt gcgattctgt catttatttt ggtcaaagat   540
ggtggtgcca aactttggct tgtgttgtca gctatttaca tgtttgtatt cttaacaaac   600
gagcacattg cggcgaactt tgcttctttc gcgattgtga aattcagtgt tgctgcggat   660
tcaattgcca acttcggtgt tggaaatatg cttcgccact ggggtgtgac tttcatcgga   720
aactttatcg gaggaggcct cttgatgggt cttccatatg ccttcctcaa taaaaacgaa   780
gatacttatg tagat                                                    795

<210>   2438
<211>   265
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transporter, FNT family, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903140 (e-150)

<400>   2438
Met Val Ser Ser Glu Phe Ile Ser Lys Ile Glu Phe Ala Cys Asn Lys 
1               5                   10                  15      

Lys Glu Ser Leu Tyr Ser Gln Ser Lys Phe Lys Tyr Ala Ile Arg Ser 
            20                  25                  30          

Met Phe Ala Gly Ala Phe Leu Thr Phe Ser Thr Ala Ala Gly Ala Val 
        35                  40                  45              

Gly Ala Asp Leu Ile Asn Lys Ile Ala Pro Gly Ser Gly Arg Phe Leu 
    50                  55                  60                  

Phe Pro Phe Val Phe Ala Trp Gly Leu Ala Tyr Ile Val Phe Leu Asn 
65                  70                  75                  80  

Ala Glu Leu Val Thr Ser Asn Met Met Phe Leu Thr Ala Gly Ser Phe 
                85                  90                  95      

Leu Lys Lys Ile Ser Trp Arg Lys Thr Ala Glu Ile Leu Leu Tyr Cys 
            100                 105                 110         

Thr Leu Phe Asn Leu Ile Gly Ala Leu Ile Ala Gly Trp Gly Phe Ala 
        115                 120                 125             

His Ser Ala Ala Tyr Ala Asn Leu Thr His Asp Ser Phe Ile Ser Gly 
    130                 135                 140                 

Val Val Glu Met Lys Leu Gly Arg Ser Asn Glu Leu Val Leu Leu Glu 
145                 150                 155                 160 

Ala Ile Leu Ala Asn Ile Phe Val Asn Ile Ala Ile Leu Ser Phe Ile 
                165                 170                 175     

Leu Val Lys Asp Gly Gly Ala Lys Leu Trp Leu Val Leu Ser Ala Ile 
            180                 185                 190         

Tyr Met Phe Val Phe Leu Thr Asn Glu His Ile Ala Ala Asn Phe Ala 
        195                 200                 205             

Ser Phe Ala Ile Val Lys Phe Ser Val Ala Ala Asp Ser Ile Ala Asn 
    210                 215                 220                 

Phe Gly Val Gly Asn Met Leu Arg His Trp Gly Val Thr Phe Ile Gly 
225                 230                 235                 240 

Asn Phe Ile Gly Gly Gly Leu Leu Met Gly Leu Pro Tyr Ala Phe Leu 
                245                 250                 255     

Asn Lys Asn Glu Asp Thr Tyr Val Asp 
            260                 265 

<210>   2439
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2439
atgaaataca gaaaacgctt cctaaaacct aaagtttgtg atataattat caagaaaaaa   60
gatttaggag tttattatgg tttcttcgga atttatctca aagat                   105

<210>   2440
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2440
Met Lys Tyr Arg Lys Arg Phe Leu Lys Pro Lys Val Cys Asp Ile Ile 
1               5                   10                  15      

Ile Lys Lys Lys Asp Leu Gly Val Tyr Tyr Gly Phe Phe Gly Ile Tyr 
            20                  25                  30          

Leu Lys Asp 
        35  

<210>   2441
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2441
ttgttagaaa tcgatttgac tgtcctgatc gatttgtcct attcttattt cattttacta   60
tatttttatg aaaatcttaa aaaatcagtg aaatcatgga tttcactgat ttgtattaat   120
aaaattgttt atatggttga t                                             141

<210>   2442
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902350 (8.E-07)

<400>   2442
Met Leu Glu Ile Asp Leu Thr Val Leu Ile Asp Leu Ser Tyr Ser Tyr 
1               5                   10                  15      

Phe Ile Leu Leu Tyr Phe Tyr Glu Asn Leu Lys Lys Ser Val Lys Ser 
            20                  25                  30          

Trp Ile Ser Leu Ile Cys Ile Asn Lys Ile Val Tyr Met Val Asp 
        35                  40                  45          

<210>   2443
<211>   369
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2443
atgaaacgcg agcaagtaat gggagaagga aattatagtc tagctagtca ccatatcttt   60
ggtgttgata atgctaataa aatgttattt tctcctttag ataatgctaa aaatggcatg   120
aagatttatc taaccgataa aaataaagtt tatacttatg aaatacgtga agtcaaacgt   180
gtgacaccgg atcgtgttga tgaagttgat gatagagatg gggtcaatga aatcacatta   240
gtaacctgtg aagaccttgc tgctacagaa cgtattattg tcaaaggtga tttgaaagaa   300
acaaaagatt attcacaaac atctaatgaa atcctaacag ctttcaatca accatataaa   360
caattttat                                                           369

<210>   2444
<211>   123
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (Sortase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903141 (5.E-68)

<400>   2444
Met Lys Arg Glu Gln Val Met Gly Glu Gly Asn Tyr Ser Leu Ala Ser 
1               5                   10                  15      

His His Ile Phe Gly Val Asp Asn Ala Asn Lys Met Leu Phe Ser Pro 
            20                  25                  30          

Leu Asp Asn Ala Lys Asn Gly Met Lys Ile Tyr Leu Thr Asp Lys Asn 
        35                  40                  45              

Lys Val Tyr Thr Tyr Glu Ile Arg Glu Val Lys Arg Val Thr Pro Asp 
    50                  55                  60                  

Arg Val Asp Glu Val Asp Asp Arg Asp Gly Val Asn Glu Ile Thr Leu 
65                  70                  75                  80  

Val Thr Cys Glu Asp Leu Ala Ala Thr Glu Arg Ile Ile Val Lys Gly 
                85                  90                  95      

Asp Leu Lys Glu Thr Lys Asp Tyr Ser Gln Thr Ser Asn Glu Ile Leu 
            100                 105                 110         

Thr Ala Phe Asn Gln Pro Tyr Lys Gln Phe Tyr 
        115                 120             

<210>   2445
<211>   432
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2445
atgagccgta tcgccactgg tgtgaaaggt gttaaccttc gtgaaggaga cacagttgtt   60
ggtgccagct tgattactga tcaagatgag gttcttatta tcacagaaaa aggatatggt   120
aagcgtacag tcgctactga atacccaaca aaaggtcgtg gtggtaaggg aatgcagaca   180
gctaaaatta ccgaaaaaaa tggcttgctg gccggtctta tgactgttca aggggatgag   240
gatttgatga ttatcactga tacaggtgtc atgattcgaa ccaatcttgc caatatttca   300
caaacaggac gtgcaactat gggagttaaa gtaatgcgcc tggatcaaga tgctcagata   360
gtgactttca caacggttgc ggtggcagaa aaagaagaag ttgggacaga aaacgaaaca   420
gaaggtgaag ca                                                       432

<210>   2446
<211>   144
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA gyrase A subunit-related

<400>   2446
Met Ser Arg Ile Ala Thr Gly Val Lys Gly Val Asn Leu Arg Glu Gly 
1               5                   10                  15      

Asp Thr Val Val Gly Ala Ser Leu Ile Thr Asp Gln Asp Glu Val Leu 
            20                  25                  30          

Ile Ile Thr Glu Lys Gly Tyr Gly Lys Arg Thr Val Ala Thr Glu Tyr 
        35                  40                  45              

Pro Thr Lys Gly Arg Gly Gly Lys Gly Met Gln Thr Ala Lys Ile Thr 
    50                  55                  60                  

Glu Lys Asn Gly Leu Leu Ala Gly Leu Met Thr Val Gln Gly Asp Glu 
65                  70                  75                  80  

Asp Leu Met Ile Ile Thr Asp Thr Gly Val Met Ile Arg Thr Asn Leu 
                85                  90                  95      

Ala Asn Ile Ser Gln Thr Gly Arg Ala Thr Met Gly Val Lys Val Met 
            100                 105                 110         

Arg Leu Asp Gln Asp Ala Gln Ile Val Thr Phe Thr Thr Val Ala Val 
        115                 120                 125             

Ala Glu Lys Glu Glu Val Gly Thr Glu Asn Glu Thr Glu Gly Glu Ala 
    130                 135                 140                 


<210>   2447
<211>   2091
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2447
atgggaattt atggtataat gttgttactt actaattgtg aaatgaggca tttattaatg   60
caggataaaa atttagtgaa tgtcaatctg acaaaggaga tgaaggcaag ttttatcgac   120
tacgccatga gtgttatcgt agcgcgagct cttcctgatg ttcgagatgg cttaaaacct   180
gttcaccgtc gcattctcta cggaatgaat gaattgggtg tgaccccaga caaaccccat   240
aaaaaatctg ctcgtattac aggggatgtc atgggtaaat atcacccaca cggggattcc   300
tctatttatg aagccatggt ccgtatggct caatggtgga gctaccgtta catgcttgta   360
gatggtcatg ggaattttgg ttccatggat ggagatagtg ctgccgctca acgttatacc   420
gaggcacgta tgagcaagat tgctctggaa atgcttcgtg atatcaacaa aaatacagtt   480
gatttcgttg ataactatga tgccaatgaa cgggaaccct tggtcttgcc agcgcgtttt   540
ccaaaccttt tggttaatgg agcaactggt atcgcggttg ggatggcaac caatattcca   600
cctcataatc tgggtgaaac cattgatgca gtgaagttgg tcatggataa tcctgaagtg   660
actaccaagg acttgatgga agtcttgcct ggaccagatt ttccaactgg tgctcttgtc   720
atggggaaat caggtatcca taaggcttat gaaacaggta aaggttcgat tgtcctacgt   780
tctcgtacag agattgaaac gactaagact ggtcgtgagc gtatcgttgt aacagaattt   840
ccttacatgg tcaataaaac caaggtgcat gagcatattg ttcgcttggt tcaggaaaaa   900
cgcattgagg gtatcacagc agtacgtgat gagtcaaacc gtgaaggtgt tcgatttgtt   960
attgaagtca agcgcgacgc ctcagccaat gttattctca ataacctctt caaaatgacc   1020
caaatgcaaa ccaattttgg tttcaatatg ctcgctatcc aaaatggtat accgaaaatt   1080
ttgtctcttc gtcagatttt ggatgcttat atcgagcacc aaaaagaagt ggttgttcgt   1140
cgtacacgtt ttgataagga aaaagcggaa gcgcgcgctc atatcttaga aggtctcttg   1200
attgcgctag accatatcga cgaagtgatt cgtatcatcc gtgctagtga aacggatgcg   1260
gaagctcaag ctgagttgat gagcaagttt aagctttctg aacgtcaaag tcaagctatc   1320
cttgatatgc gtcttcgtcg tttgacaggt ttggaacgcg ataagattca atctgagtat   1380
gatgacctct tggctctgat tgcggattta gcagatattc ttgctaagcc tgaacgtgtt   1440
tctcaaatta tcaaagacga attggatgaa gttaaacgta aattttctga taagcgccgt   1500
acagagttga tgattggaca ggtcttgagt ctcgaggatg aggacttgat tgaagaatcg   1560
gatgtcttga ttaccctttc taacagaggc tacattaagc gtttggatca ggacgagttc   1620
actgctcaaa aacgtggggg tcgtggtgtc caaggaacgg gagtgaaaga tgatgacttt   1680
gttcgtgagt tagtgtcaac tagcacccat gatcatctgc tcttcttcac aaacaaggga   1740
cgtgtctatc gtcttaaagg ttatgaaatt cctgagtatg gtcggactgc caaagggcta   1800
ccagtagtca atctcttgaa attggatgaa gacgaaagta ttcagacggt tatcaatgtt   1860
gagtctgatc gcagtgatga tgcttatctc ttctttacaa cccgtcacgg tattgtgaag   1920
agaaccagtg ttaaggagtt tgccaatatt cgtcaaaatg gtctcaaagc gctgaattta   1980
aaggatgaag atgagttaat caatgtcttg ttggcagaag gagatatgga tattatcatt   2040
ggtaccaagt ttggttatgc agttcgcttt aatcaatcgc cgttcgtggt a            2091

<210>   2448
<211>   697
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA gyrase subunit A, FRAMESHIFT (gyrA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903142 (0.E+01)

<400>   2448
Met Gly Ile Tyr Gly Ile Met Leu Leu Leu Thr Asn Cys Glu Met Arg 
1               5                   10                  15      

His Leu Leu Met Gln Asp Lys Asn Leu Val Asn Val Asn Leu Thr Lys 
            20                  25                  30          

Glu Met Lys Ala Ser Phe Ile Asp Tyr Ala Met Ser Val Ile Val Ala 
        35                  40                  45              

Arg Ala Leu Pro Asp Val Arg Asp Gly Leu Lys Pro Val His Arg Arg 
    50                  55                  60                  

Ile Leu Tyr Gly Met Asn Glu Leu Gly Val Thr Pro Asp Lys Pro His 
65                  70                  75                  80  

Lys Lys Ser Ala Arg Ile Thr Gly Asp Val Met Gly Lys Tyr His Pro 
                85                  90                  95      

His Gly Asp Ser Ser Ile Tyr Glu Ala Met Val Arg Met Ala Gln Trp 
            100                 105                 110         

Trp Ser Tyr Arg Tyr Met Leu Val Asp Gly His Gly Asn Phe Gly Ser 
        115                 120                 125             

Met Asp Gly Asp Ser Ala Ala Ala Gln Arg Tyr Thr Glu Ala Arg Met 
    130                 135                 140                 

Ser Lys Ile Ala Leu Glu Met Leu Arg Asp Ile Asn Lys Asn Thr Val 
145                 150                 155                 160 

Asp Phe Val Asp Asn Tyr Asp Ala Asn Glu Arg Glu Pro Leu Val Leu 
                165                 170                 175     

Pro Ala Arg Phe Pro Asn Leu Leu Val Asn Gly Ala Thr Gly Ile Ala 
            180                 185                 190         

Val Gly Met Ala Thr Asn Ile Pro Pro His Asn Leu Gly Glu Thr Ile 
        195                 200                 205             

Asp Ala Val Lys Leu Val Met Asp Asn Pro Glu Val Thr Thr Lys Asp 
    210                 215                 220                 

Leu Met Glu Val Leu Pro Gly Pro Asp Phe Pro Thr Gly Ala Leu Val 
225                 230                 235                 240 

Met Gly Lys Ser Gly Ile His Lys Ala Tyr Glu Thr Gly Lys Gly Ser 
                245                 250                 255     

Ile Val Leu Arg Ser Arg Thr Glu Ile Glu Thr Thr Lys Thr Gly Arg 
            260                 265                 270         

Glu Arg Ile Val Val Thr Glu Phe Pro Tyr Met Val Asn Lys Thr Lys 
        275                 280                 285             

Val His Glu His Ile Val Arg Leu Val Gln Glu Lys Arg Ile Glu Gly 
    290                 295                 300                 

Ile Thr Ala Val Arg Asp Glu Ser Asn Arg Glu Gly Val Arg Phe Val 
305                 310                 315                 320 

Ile Glu Val Lys Arg Asp Ala Ser Ala Asn Val Ile Leu Asn Asn Leu 
                325                 330                 335     

Phe Lys Met Thr Gln Met Gln Thr Asn Phe Gly Phe Asn Met Leu Ala 
            340                 345                 350         

Ile Gln Asn Gly Ile Pro Lys Ile Leu Ser Leu Arg Gln Ile Leu Asp 
        355                 360                 365             

Ala Tyr Ile Glu His Gln Lys Glu Val Val Val Arg Arg Thr Arg Phe 
    370                 375                 380                 

Asp Lys Glu Lys Ala Glu Ala Arg Ala His Ile Leu Glu Gly Leu Leu 

385                 390                 395                 400 

Ile Ala Leu Asp His Ile Asp Glu Val Ile Arg Ile Ile Arg Ala Ser 
                405                 410                 415     

Glu Thr Asp Ala Glu Ala Gln Ala Glu Leu Met Ser Lys Phe Lys Leu 
            420                 425                 430         

Ser Glu Arg Gln Ser Gln Ala Ile Leu Asp Met Arg Leu Arg Arg Leu 
        435                 440                 445             

Thr Gly Leu Glu Arg Asp Lys Ile Gln Ser Glu Tyr Asp Asp Leu Leu 
    450                 455                 460                 

Ala Leu Ile Ala Asp Leu Ala Asp Ile Leu Ala Lys Pro Glu Arg Val 
465                 470                 475                 480 

Ser Gln Ile Ile Lys Asp Glu Leu Asp Glu Val Lys Arg Lys Phe Ser 
                485                 490                 495     

Asp Lys Arg Arg Thr Glu Leu Met Ile Gly Gln Val Leu Ser Leu Glu 
            500                 505                 510         

Asp Glu Asp Leu Ile Glu Glu Ser Asp Val Leu Ile Thr Leu Ser Asn 
        515                 520                 525             

Arg Gly Tyr Ile Lys Arg Leu Asp Gln Asp Glu Phe Thr Ala Gln Lys 
    530                 535                 540                 

Arg Gly Gly Arg Gly Val Gln Gly Thr Gly Val Lys Asp Asp Asp Phe 
545                 550                 555                 560 

Val Arg Glu Leu Val Ser Thr Ser Thr His Asp His Leu Leu Phe Phe 
                565                 570                 575     

Thr Asn Lys Gly Arg Val Tyr Arg Leu Lys Gly Tyr Glu Ile Pro Glu 
            580                 585                 590         

Tyr Gly Arg Thr Ala Lys Gly Leu Pro Val Val Asn Leu Leu Lys Leu 
        595                 600                 605             

Asp Glu Asp Glu Ser Ile Gln Thr Val Ile Asn Val Glu Ser Asp Arg 
    610                 615                 620                 

Ser Asp Asp Ala Tyr Leu Phe Phe Thr Thr Arg His Gly Ile Val Lys 
625                 630                 635                 640 

Arg Thr Ser Val Lys Glu Phe Ala Asn Ile Arg Gln Asn Gly Leu Lys 
                645                 650                 655     

Ala Leu Asn Leu Lys Asp Glu Asp Glu Leu Ile Asn Val Leu Leu Ala 
            660                 665                 670         

Glu Gly Asp Met Asp Ile Ile Ile Gly Thr Lys Phe Gly Tyr Ala Val 
        675                 680                 685             

Arg Phe Asn Gln Ser Pro Phe Val Val 
    690                 695         

<210>   2449
<211>   984
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2449
atgacttcaa ctaaacaaca caaaaaagtt atccttgtcg gtgatggtgc tgtaggttca   60
tcttacgctt ttgcacttgt taaccaagga attgcacaag agcttggaat tatcgaaatt   120
ccacaattgc atgaaaaagc tgttggtgat gcgcttgacc ttagtcacgc ccttgccttc   180
acttcaccta aaaaaatcta tgcagctcaa tactctgact gtgcagacgc tgaccttgtt   240
gtgatcactg caggtgcacc tcaaaaacca ggtgaaactc gtcttgacct tgtaggtaaa   300
aaccttgcta tcaacaaatc aatcgtaact caagttgttg aatctggttt caaaggtatc   360
ttccttgttg ctgctaaccc agttgacgtt ttgacttact caacttggaa attctctggt   420
ttccctaaag aacgcgttat cggttcaggt acttcacttg actcagctcg tttccgtcaa   480
gcacttgctg aaaaattgga tgtggatgct cgttcagtgc acgcctacat catgggtgaa   540
cacggtgact ctgagttcgc tgtttggtca cacgctaaca tcgctggtgt aaaccttgaa   600
gaattcctta aagacactca aaatgttcaa gaagctgaat tgattgaatt gttcgaaggt   660
gttcgtgatg cagcctacac aatcatcaac aaaaaaggtg caacatacta cggtatcgca   720
gtagcccttg ctcgtatcac taaagcaatc cttgacgatg aaaacgcagt acttccactt   780
tcagtattcc aagaaggtca atacggagtt gagaatgtct ttatcggtca accagctgtt   840
gttggtgcac atggtatcgt tcgtccagta aatatcccat tgaacgacgc agaaactcaa   900
aaaatgcaag catctgctaa agaattacaa gctatcattg acgaagcatg gaaaaaccca   960
gaattccaag aagcttctaa aaac                                          984

<210>   2450
<211>   328
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   L-lactate dehydrogenase (ldh)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903143 (0.E+01)

<400>   2450
Met Thr Ser Thr Lys Gln His Lys Lys Val Ile Leu Val Gly Asp Gly 
1               5                   10                  15      

Ala Val Gly Ser Ser Tyr Ala Phe Ala Leu Val Asn Gln Gly Ile Ala 
            20                  25                  30          

Gln Glu Leu Gly Ile Ile Glu Ile Pro Gln Leu His Glu Lys Ala Val 
        35                  40                  45              

Gly Asp Ala Leu Asp Leu Ser His Ala Leu Ala Phe Thr Ser Pro Lys 
    50                  55                  60                  

Lys Ile Tyr Ala Ala Gln Tyr Ser Asp Cys Ala Asp Ala Asp Leu Val 
65                  70                  75                  80  

Val Ile Thr Ala Gly Ala Pro Gln Lys Pro Gly Glu Thr Arg Leu Asp 
                85                  90                  95      

Leu Val Gly Lys Asn Leu Ala Ile Asn Lys Ser Ile Val Thr Gln Val 
            100                 105                 110         

Val Glu Ser Gly Phe Lys Gly Ile Phe Leu Val Ala Ala Asn Pro Val 
        115                 120                 125             

Asp Val Leu Thr Tyr Ser Thr Trp Lys Phe Ser Gly Phe Pro Lys Glu 
    130                 135                 140                 

Arg Val Ile Gly Ser Gly Thr Ser Leu Asp Ser Ala Arg Phe Arg Gln 
145                 150                 155                 160 

Ala Leu Ala Glu Lys Leu Asp Val Asp Ala Arg Ser Val His Ala Tyr 
                165                 170                 175     

Ile Met Gly Glu His Gly Asp Ser Glu Phe Ala Val Trp Ser His Ala 
            180                 185                 190         

Asn Ile Ala Gly Val Asn Leu Glu Glu Phe Leu Lys Asp Thr Gln Asn 
        195                 200                 205             

Val Gln Glu Ala Glu Leu Ile Glu Leu Phe Glu Gly Val Arg Asp Ala 
    210                 215                 220                 

Ala Tyr Thr Ile Ile Asn Lys Lys Gly Ala Thr Tyr Tyr Gly Ile Ala 
225                 230                 235                 240 

Val Ala Leu Ala Arg Ile Thr Lys Ala Ile Leu Asp Asp Glu Asn Ala 
                245                 250                 255     

Val Leu Pro Leu Ser Val Phe Gln Glu Gly Gln Tyr Gly Val Glu Asn 
            260                 265                 270         

Val Phe Ile Gly Gln Pro Ala Val Val Gly Ala His Gly Ile Val Arg 
        275                 280                 285             

Pro Val Asn Ile Pro Leu Asn Asp Ala Glu Thr Gln Lys Met Gln Ala 
    290                 295                 300                 

Ser Ala Lys Glu Leu Gln Ala Ile Ile Asp Glu Ala Trp Lys Asn Pro 
305                 310                 315                 320 

Glu Phe Gln Glu Ala Ser Lys Asn 
                325             

<210>   2451
<211>   3252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2451
atgccagtag aaattaaaac cactaaagaa attcatccta aaatctatgc ctacaccaca   60
ccgacagtaa ccagtaatga aggctggatt aagattgggt atacagaacg tgatgtcaca   120
caacgtatca aggagcaaac gcatacagct catatagcta cagatgtctt atggactggt   180
gatgcagctt atacagaaga gcctgataag gggaaaactt tcaaggacca tgatttccac   240
catttccttt ctttccatga tgtagaacgt cgtcccaaga cggaatggtt ctattttaat   300
ggaactcctg aaaaatcaaa aaatcttttt gataagtttg ttcagcatga tttgtctggt   360
tatcagcctg gaaaaggaca ggactatact ctgcgacaag agcaagaaga agcagttgct   420
aagacattag cttatttcca agaacatgct ggaggcaagt ttctctggaa tgccaagcca   480
cgctttggta aaaccttgtc tacctatgac ctagctcgac ggatggaagc tgtcaatgtc   540
ctaattgtaa caaaccgccc tgccattgct aactcatggt atgatgattt tgaaacattc   600
atagcaggtc aaacgactta caagtttgtt tctgaatcag atagccttaa gagtcgtcca   660
atcttgtcac gacaagaatt tcttggtatt ttagctgacg atgtaagaca acttgctttt   720
atcagtctcc aagacttgaa aggatctgtt tatttaggtg gagagcacga taaactcaaa   780
tgggtaactg atctgcattg ggacttgttg gttattgacg aggctcatga aggagttgat   840
accttcaaga ctgaccaagc ctttaataag attcgacgaa attttactct gcatttgtca   900
ggtacatcat ttaaagcatt ggctaaagga gattttacag aggaacaaat ctacaactgg   960
tcttatgctg atgagcaggc tgctaagtat tcgtggtctc ttgagcaaga agaggaaaat   1020
ccttatgaaa gcttgcctca gttgaatctc tttacctatc aaatgtctca gatgattggc   1080
gaaaagttag aaaaaggcgc tcagatcgat ggtgaaaata ttgactatgt ttttgactta   1140
agtgaatttt tcgctacaga tgataaaggg aaatttattc atgagcatga tgtcagaaat   1200
tggttagata ctctatcaag caatgaaaaa tatccatttt caaccaaaga actccgtaat   1260
gaactcaagc atactttttg gcttttagaa cgtgtcgctt cggccaaagc attaaaagcc   1320
ctactagaag aacacccaat ctatgaaaac tatgagatcg ttctagctgc tggtgacgga   1380
cgtatgtccg aagaagacga taaagtcaaa ctcaaatcct tggacttggt tagaaaagcg   1440
atagcagaga atgacaaaac cattacccta tccgttggtc agctgacgac aggtgtcact   1500
atccctgaat ggacaggtgt attgatgtta tcaaatttga aatcaccagc tctttatatg   1560
caggccgcct tccgtgctca aaatccttac tcatggagcg ataacaaagg aaatcacttt   1620
cgcaaagaaa gagcctatgt atttgacttt gcgccggaaa gaaccttgat tctctttgat   1680
gagtttgcca acaacttatt gcttgtaact gcagctggta gaggaacttc agctacacgc   1740
gaagaaaata ttagagaatt attaaacttc tttccaatta ttgccgaaga ccgtgctggt   1800
aagatggttg aaattgatgc aaaggcagtt ctaaccactc ctcgccagat aaaagctaga   1860
gaagttctta aacgaggttt tatgtccaat ctcttatttg ataatattag tggtattttc   1920
caagcaagtc aaacagtttt agatatttta aatgagctgc cagttgaaaa ggaagggaag   1980
gtacaagata gttctgattt attagatttt tcagatgtta cagtcgatga tgagggaaat   2040
gcagtagtag accatgaaat tgtagttaat cagcaaatgc gactttttgg tgaaaaagtt   2100
tatggacttg gtgaatctgt tgctgagtta gtcacaaaag atgaggaacg aactcaaaaa   2160
cagctggtca atgacttgag taagaccgtt tcttcagtga ttgtagagga attgaaagca   2220
gattattctc taaaaacaag ggaaactgag caaattaaga aacaaattac agcaacactt   2280
gagaatgaaa ttcgaaaaaa tgatatcgaa agaaaaattt ctgaagctca tatcaagcaa   2340
gagttgcaac agcagctcaa agaagcaaat gataaagcgc aaaaagataa gattcaagaa   2400
gatttggaaa aacgtttaga agaaaataaa ctcattcata aagaaaaact agaacaaaca   2460
ctcaaaaaag aagtggaaaa aatgcctgag aaatttatcg aacaggttga gataaaacgt   2520
gtggaacagt tgaaacaatc agctcaagat gaaattcgtg accatttacg agggtttgca   2580
agaacaattc caagttttat tatggcttac ggtgatcaaa ctctaacact tgataatttt   2640
gatgcctttg ttcctgaaca tgttttttat gaagtaacag ggattacgat tgatcagttt   2700
agatatttgc gagatggtgg gcaggatttt gcagggcatc tctttgataa agcaacattt   2760
gacgaagcta ttcaagaatt tcttcgcaag aaaaaggagt tggcggatta ttttaaagat   2820
caaaaagaag acatttttga ctatattcca ccgcagaaga ccaaccaaat tttcactcct   2880
aaacgagtgg tgaaaaggat ggtagatgat ttggaaaagg aaaatccagg gatttttgat   2940
gatccatcta agacttttat tgatttatat atgaagtcag gcctctatat tgcagaactt   3000
gtgaagcggt tatataatag caatggcttg aaagaggcct ttccaaatcc tgaagaacgc   3060
ttaaaacata ttttggaaaa gcaagtttat ggatttgctc cgtctgagat tatctataac   3120
atttccacta attttatatt tggcaatctt tctaaagata tcagtaggaa gaattttgtt   3180
ttagcagata ccattccagc ggctaaagaa gggagcattc aaaagttggt tgattcctat   3240
tttgaaaata at                                                       3252

<210>   2452
<211>   1084
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   type II restriction endonuclease, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903144 (0.E+01)

<400>   2452
Met Pro Val Glu Ile Lys Thr Thr Lys Glu Ile His Pro Lys Ile Tyr 
1               5                   10                  15      

Ala Tyr Thr Thr Pro Thr Val Thr Ser Asn Glu Gly Trp Ile Lys Ile 
            20                  25                  30          

Gly Tyr Thr Glu Arg Asp Val Thr Gln Arg Ile Lys Glu Gln Thr His 
        35                  40                  45              

Thr Ala His Ile Ala Thr Asp Val Leu Trp Thr Gly Asp Ala Ala Tyr 
    50                  55                  60                  

Thr Glu Glu Pro Asp Lys Gly Lys Thr Phe Lys Asp His Asp Phe His 
65                  70                  75                  80  

His Phe Leu Ser Phe His Asp Val Glu Arg Arg Pro Lys Thr Glu Trp 
                85                  90                  95      

Phe Tyr Phe Asn Gly Thr Pro Glu Lys Ser Lys Asn Leu Phe Asp Lys 
            100                 105                 110         

Phe Val Gln His Asp Leu Ser Gly Tyr Gln Pro Gly Lys Gly Gln Asp 
        115                 120                 125             

Tyr Thr Leu Arg Gln Glu Gln Glu Glu Ala Val Ala Lys Thr Leu Ala 
    130                 135                 140                 

Tyr Phe Gln Glu His Ala Gly Gly Lys Phe Leu Trp Asn Ala Lys Pro 
145                 150                 155                 160 

Arg Phe Gly Lys Thr Leu Ser Thr Tyr Asp Leu Ala Arg Arg Met Glu 
                165                 170                 175     

Ala Val Asn Val Leu Ile Val Thr Asn Arg Pro Ala Ile Ala Asn Ser 
            180                 185                 190         

Trp Tyr Asp Asp Phe Glu Thr Phe Ile Ala Gly Gln Thr Thr Tyr Lys 
        195                 200                 205             

Phe Val Ser Glu Ser Asp Ser Leu Lys Ser Arg Pro Ile Leu Ser Arg 
    210                 215                 220                 

Gln Glu Phe Leu Gly Ile Leu Ala Asp Asp Val Arg Gln Leu Ala Phe 
225                 230                 235                 240 

Ile Ser Leu Gln Asp Leu Lys Gly Ser Val Tyr Leu Gly Gly Glu His 
                245                 250                 255     

Asp Lys Leu Lys Trp Val Thr Asp Leu His Trp Asp Leu Leu Val Ile 
            260                 265                 270         

Asp Glu Ala His Glu Gly Val Asp Thr Phe Lys Thr Asp Gln Ala Phe 
        275                 280                 285             

Asn Lys Ile Arg Arg Asn Phe Thr Leu His Leu Ser Gly Thr Ser Phe 
    290                 295                 300                 

Lys Ala Leu Ala Lys Gly Asp Phe Thr Glu Glu Gln Ile Tyr Asn Trp 
305                 310                 315                 320 

Ser Tyr Ala Asp Glu Gln Ala Ala Lys Tyr Ser Trp Ser Leu Glu Gln 
                325                 330                 335     

Glu Glu Glu Asn Pro Tyr Glu Ser Leu Pro Gln Leu Asn Leu Phe Thr 
            340                 345                 350         

Tyr Gln Met Ser Gln Met Ile Gly Glu Lys Leu Glu Lys Gly Ala Gln 
        355                 360                 365             

Ile Asp Gly Glu Asn Ile Asp Tyr Val Phe Asp Leu Ser Glu Phe Phe 
    370                 375                 380                 

Ala Thr Asp Asp Lys Gly Lys Phe Ile His Glu His Asp Val Arg Asn 
385                 390                 395                 400 

Trp Leu Asp Thr Leu Ser Ser Asn Glu Lys Tyr Pro Phe Ser Thr Lys 
                405                 410                 415     

Glu Leu Arg Asn Glu Leu Lys His Thr Phe Trp Leu Leu Glu Arg Val 
            420                 425                 430         

Ala Ser Ala Lys Ala Leu Lys Ala Leu Leu Glu Glu His Pro Ile Tyr 
        435                 440                 445             

Glu Asn Tyr Glu Ile Val Leu Ala Ala Gly Asp Gly Arg Met Ser Glu 
    450                 455                 460                 

Glu Asp Asp Lys Val Lys Leu Lys Ser Leu Asp Leu Val Arg Lys Ala 
465                 470                 475                 480 

Ile Ala Glu Asn Asp Lys Thr Ile Thr Leu Ser Val Gly Gln Leu Thr 
                485                 490                 495     

Thr Gly Val Thr Ile Pro Glu Trp Thr Gly Val Leu Met Leu Ser Asn 
            500                 505                 510         

Leu Lys Ser Pro Ala Leu Tyr Met Gln Ala Ala Phe Arg Ala Gln Asn 
        515                 520                 525             

Pro Tyr Ser Trp Ser Asp Asn Lys Gly Asn His Phe Arg Lys Glu Arg 
    530                 535                 540                 

Ala Tyr Val Phe Asp Phe Ala Pro Glu Arg Thr Leu Ile Leu Phe Asp 
545                 550                 555                 560 

Glu Phe Ala Asn Asn Leu Leu Leu Val Thr Ala Ala Gly Arg Gly Thr 
                565                 570                 575     

Ser Ala Thr Arg Glu Glu Asn Ile Arg Glu Leu Leu Asn Phe Phe Pro 
            580                 585                 590         

Ile Ile Ala Glu Asp Arg Ala Gly Lys Met Val Glu Ile Asp Ala Lys 
        595                 600                 605             

Ala Val Leu Thr Thr Pro Arg Gln Ile Lys Ala Arg Glu Val Leu Lys 
    610                 615                 620                 

Arg Gly Phe Met Ser Asn Leu Leu Phe Asp Asn Ile Ser Gly Ile Phe 
625                 630                 635                 640 

Gln Ala Ser Gln Thr Val Leu Asp Ile Leu Asn Glu Leu Pro Val Glu 
                645                 650                 655     

Lys Glu Gly Lys Val Gln Asp Ser Ser Asp Leu Leu Asp Phe Ser Asp 
            660                 665                 670         

Val Thr Val Asp Asp Glu Gly Asn Ala Val Val Asp His Glu Ile Val 
        675                 680                 685             

Val Asn Gln Gln Met Arg Leu Phe Gly Glu Lys Val Tyr Gly Leu Gly 
    690                 695                 700                 

Glu Ser Val Ala Glu Leu Val Thr Lys Asp Glu Glu Arg Thr Gln Lys 
705                 710                 715                 720 

Gln Leu Val Asn Asp Leu Ser Lys Thr Val Ser Ser Val Ile Val Glu 
                725                 730                 735     

Glu Leu Lys Ala Asp Tyr Ser Leu Lys Thr Arg Glu Thr Glu Gln Ile 
            740                 745                 750         

Lys Lys Gln Ile Thr Ala Thr Leu Glu Asn Glu Ile Arg Lys Asn Asp 
        755                 760                 765             

Ile Glu Arg Lys Ile Ser Glu Ala His Ile Lys Gln Glu Leu Gln Gln 
    770                 775                 780                 

Gln Leu Lys Glu Ala Asn Asp Lys Ala Gln Lys Asp Lys Ile Gln Glu 
785                 790                 795                 800 

Asp Leu Glu Lys Arg Leu Glu Glu Asn Lys Leu Ile His Lys Glu Lys 
                805                 810                 815     

Leu Glu Gln Thr Leu Lys Lys Glu Val Glu Lys Met Pro Glu Lys Phe 
            820                 825                 830         

Ile Glu Gln Val Glu Ile Lys Arg Val Glu Gln Leu Lys Gln Ser Ala 
        835                 840                 845             


Gln Asp Glu Ile Arg Asp His Leu Arg Gly Phe Ala Arg Thr Ile Pro 
    850                 855                 860                 

Ser Phe Ile Met Ala Tyr Gly Asp Gln Thr Leu Thr Leu Asp Asn Phe 
865                 870                 875                 880 

Asp Ala Phe Val Pro Glu His Val Phe Tyr Glu Val Thr Gly Ile Thr 
                885                 890                 895     

Ile Asp Gln Phe Arg Tyr Leu Arg Asp Gly Gly Gln Asp Phe Ala Gly 
            900                 905                 910         

His Leu Phe Asp Lys Ala Thr Phe Asp Glu Ala Ile Gln Glu Phe Leu 
        915                 920                 925             

Arg Lys Lys Lys Glu Leu Ala Asp Tyr Phe Lys Asp Gln Lys Glu Asp 
    930                 935                 940                 

Ile Phe Asp Tyr Ile Pro Pro Gln Lys Thr Asn Gln Ile Phe Thr Pro 
945                 950                 955                 960 

Lys Arg Val Val Lys Arg Met Val Asp Asp Leu Glu Lys Glu Asn Pro 
                965                 970                 975     

Gly Ile Phe Asp Asp Pro Ser Lys Thr Phe Ile Asp Leu Tyr Met Lys 
            980                 985                 990         

Ser Gly Leu Tyr Ile Ala Glu Leu Val Lys Arg Leu Tyr Asn Ser Asn 
        995                 1000                1005            

Gly Leu Lys Glu Ala Phe Pro Asn Pro Glu Glu Arg Leu Lys His Ile 
    1010                1015                1020                

Leu Glu Lys Gln Val Tyr Gly Phe Ala Pro Ser Glu Ile Ile Tyr Asn 
1025                1030                1035                1040

Ile Ser Thr Asn Phe Ile Phe Gly Asn Leu Ser Lys Asp Ile Ser Arg 
                1045                1050                1055    

Lys Asn Phe Val Leu Ala Asp Thr Ile Pro Ala Ala Lys Glu Gly Ser 
            1060                1065                1070        

Ile Gln Lys Leu Val Asp Ser Tyr Phe Glu Asn Asn 
        1075                1080                

<210>   2453
<211>   1875
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2453
ttgctgatga caatagatat tagtgaagaa agtttggcta aagaatcggc tgacttatta   60
aaaattcttt taaaagatcg aacgacaaag aaatcaattg tttgggctac gcattcttat   120
gaattgttag gaaagggatt tgctccaagt gatcgcatca atccaagtaa ggttactgga   180
aactttgcca acttgattca gcccagatct gaaaaatcca aatatgaaca aaaagatcgg   240
acaaaaataa gggcagaagt gtttacacca acgtggttgg tcgcaaagca aaatggatat   300
gtagaatcga aattaggctc gttaagtctt gaggagtatg tggacttacg atggttagag   360
gtaacttgtg gtgaagcacc ttatatggta acgagatatg ataccgtaac tggtgaggaa   420
attccattat ctgagcgagt tggttttgtt gatagaaaac tgcaacggat tagtcgtgag   480
gtttcagatg aagtcacatt ttataaactt gtaaaagatg cttatcatgc ttcgtatggt   540
tatgagtatc aaggagattc tctccttttg gcgcgtgaga atcttttggc aacttttgag   600
gactattatc tagctaagac tggaaatcaa ccaacattag agcaaaagaa agaaattgcg   660
actattatct cttacaatgt ctttcagatg gatggattga aaaaaagtag tccttattca   720
gctaaacaaa agcaatctca acaattgagt ttgtttgcgg atgagctaga agtccaagaa   780
gtagaagaat ctaaaaccca tatcaaagac tggaaaaaga atagaatgat aggttttgag   840
cgcctatcta gcgaggaaag tgaaatgaaa tttgatgtcg tgataggaaa tcctccgtat   900
caggaaacag gagaagccag agatgagccg atatatcact attttattga tgaagcttat   960
aaaatcgcag ataaatctat actaatcacc ccagcaaggt ttttatttaa agctggtcaa   1020
actcctaaaa attggatgga aaagatgctt gaagacaagc atttaaaagt tcaattctat   1080
gaacttaaaa gcggtaaagt atttacagga acggatatta agggtggagt agcaataact   1140
tatcgtgatg ttgataaaga tttgggacca atcggagtat ttactatttt tgaaactttg   1200
aatggtattg taaaaaaaat cgaaaaacat ccagaatttg aaactttttc tgatttagtt   1260
tatcctcaag gtatttatag attttcaaat aaactttttt ctgattatcc aaatgctgaa   1320
aagctgcaag gaaaagggac aaaaaataaa attgtttcga aatcactaac tcagttagat   1380
tttgttttca aaaacaacga agaaaaagac catgttgctc tacttggaag aattggctcc   1440
gaacgtgttt atcgatatat taataaaaaa tatttagatt taccggaaac attcgaaaat   1500
tataatgttt ttgtaccaga agctaatgga agtggtgcct taggtgaagt cttatcaaca   1560
cccctaatcg gggaacccct aatcgggcat acagatactt ttttatctat tggtaatttt   1620
aaaacaaaat ttgaagccga tgcttgtatt aaatttatta aaactaaatt cgctagagta   1680
ttattaggtg ttttgaaagt tactcagcat aattcacgca aaacttggta ttacgtcccc   1740
ctccaagact ttacggtcaa ttcggacatt gattggacac aatcagtgac tgatattgac   1800
cgccagcttg atcaaaaata tgacctttcc cctgaagaaa ttgcctttat tgagaatcat   1860
gtaagggaga tggat                                                    1875

<210>   2454
<211>   625
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type II restriction endonuclease, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903145 (0.E+01)

<400>   2454
Met Leu Met Thr Ile Asp Ile Ser Glu Glu Ser Leu Ala Lys Glu Ser 
1               5                   10                  15      

Ala Asp Leu Leu Lys Ile Leu Leu Lys Asp Arg Thr Thr Lys Lys Ser 
            20                  25                  30          

Ile Val Trp Ala Thr His Ser Tyr Glu Leu Leu Gly Lys Gly Phe Ala 
        35                  40                  45              

Pro Ser Asp Arg Ile Asn Pro Ser Lys Val Thr Gly Asn Phe Ala Asn 
    50                  55                  60                  

Leu Ile Gln Pro Arg Ser Glu Lys Ser Lys Tyr Glu Gln Lys Asp Arg 
65                  70                  75                  80  

Thr Lys Ile Arg Ala Glu Val Phe Thr Pro Thr Trp Leu Val Ala Lys 
                85                  90                  95      

Gln Asn Gly Tyr Val Glu Ser Lys Leu Gly Ser Leu Ser Leu Glu Glu 
            100                 105                 110         

Tyr Val Asp Leu Arg Trp Leu Glu Val Thr Cys Gly Glu Ala Pro Tyr 
        115                 120                 125             

Met Val Thr Arg Tyr Asp Thr Val Thr Gly Glu Glu Ile Pro Leu Ser 
    130                 135                 140                 

Glu Arg Val Gly Phe Val Asp Arg Lys Leu Gln Arg Ile Ser Arg Glu 
145                 150                 155                 160 

Val Ser Asp Glu Val Thr Phe Tyr Lys Leu Val Lys Asp Ala Tyr His 
                165                 170                 175     

Ala Ser Tyr Gly Tyr Glu Tyr Gln Gly Asp Ser Leu Leu Leu Ala Arg 
            180                 185                 190         

Glu Asn Leu Leu Ala Thr Phe Glu Asp Tyr Tyr Leu Ala Lys Thr Gly 
        195                 200                 205             

Asn Gln Pro Thr Leu Glu Gln Lys Lys Glu Ile Ala Thr Ile Ile Ser 
    210                 215                 220                 

Tyr Asn Val Phe Gln Met Asp Gly Leu Lys Lys Ser Ser Pro Tyr Ser 
225                 230                 235                 240 

Ala Lys Gln Lys Gln Ser Gln Gln Leu Ser Leu Phe Ala Asp Glu Leu 
                245                 250                 255     

Glu Val Gln Glu Val Glu Glu Ser Lys Thr His Ile Lys Asp Trp Lys 
            260                 265                 270         

Lys Asn Arg Met Ile Gly Phe Glu Arg Leu Ser Ser Glu Glu Ser Glu 
        275                 280                 285             

Met Lys Phe Asp Val Val Ile Gly Asn Pro Pro Tyr Gln Glu Thr Gly 
    290                 295                 300                 

Glu Ala Arg Asp Glu Pro Ile Tyr His Tyr Phe Ile Asp Glu Ala Tyr 
305                 310                 315                 320 

Lys Ile Ala Asp Lys Ser Ile Leu Ile Thr Pro Ala Arg Phe Leu Phe 
                325                 330                 335     

Lys Ala Gly Gln Thr Pro Lys Asn Trp Met Glu Lys Met Leu Glu Asp 
            340                 345                 350         

Lys His Leu Lys Val Gln Phe Tyr Glu Leu Lys Ser Gly Lys Val Phe 
        355                 360                 365             

Thr Gly Thr Asp Ile Lys Gly Gly Val Ala Ile Thr Tyr Arg Asp Val 
    370                 375                 380                 

Asp Lys Asp Leu Gly Pro Ile Gly Val Phe Thr Ile Phe Glu Thr Leu 
385                 390                 395                 400 

Asn Gly Ile Val Lys Lys Ile Glu Lys His Pro Glu Phe Glu Thr Phe 
                405                 410                 415     

Ser Asp Leu Val Tyr Pro Gln Gly Ile Tyr Arg Phe Ser Asn Lys Leu 
            420                 425                 430         

Phe Ser Asp Tyr Pro Asn Ala Glu Lys Leu Gln Gly Lys Gly Thr Lys 
        435                 440                 445             

Asn Lys Ile Val Ser Lys Ser Leu Thr Gln Leu Asp Phe Val Phe Lys 
    450                 455                 460                 

Asn Asn Glu Glu Lys Asp His Val Ala Leu Leu Gly Arg Ile Gly Ser 
465                 470                 475                 480 

Glu Arg Val Tyr Arg Tyr Ile Asn Lys Lys Tyr Leu Asp Leu Pro Glu 
                485                 490                 495     

Thr Phe Glu Asn Tyr Asn Val Phe Val Pro Glu Ala Asn Gly Ser Gly 
            500                 505                 510         

Ala Leu Gly Glu Val Leu Ser Thr Pro Leu Ile Gly Glu Pro Leu Ile 
        515                 520                 525             

Gly His Thr Asp Thr Phe Leu Ser Ile Gly Asn Phe Lys Thr Lys Phe 
    530                 535                 540                 

Glu Ala Asp Ala Cys Ile Lys Phe Ile Lys Thr Lys Phe Ala Arg Val 
545                 550                 555                 560 

Leu Leu Gly Val Leu Lys Val Thr Gln His Asn Ser Arg Lys Thr Trp 
                565                 570                 575     

Tyr Tyr Val Pro Leu Gln Asp Phe Thr Val Asn Ser Asp Ile Asp Trp 
            580                 585                 590         

Thr Gln Ser Val Thr Asp Ile Asp Arg Gln Leu Asp Gln Lys Tyr Asp 
        595                 600                 605             

Leu Ser Pro Glu Glu Ile Ala Phe Ile Glu Asn His Val Arg Glu Met 
    610                 615                 620                 

Asp 
625 

<210>   2455
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2455
ttgtataaat tagttccaac aagacgtttt atcaagcaat tgaaaaaatt ggaccgttat   60
acgcagaagc taattacaaa ctatttacaa accaatgttt tggaagaccc aagacgacac   120
ggaaaggctt tggttggtaa tcgcgttggt caatggcgct atagaattgg taattatcga   180
gttatcgtac aaattgtaga tgatgaatta gtcgttgcta ctctagaagt tggtcatcgg   240
agagatattt at                                                       252

<210>   2456
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903146 (6.E-45)

<400>   2456
Met Tyr Lys Leu Val Pro Thr Arg Arg Phe Ile Lys Gln Leu Lys Lys 
1               5                   10                  15      

Leu Asp Arg Tyr Thr Gln Lys Leu Ile Thr Asn Tyr Leu Gln Thr Asn 
            20                  25                  30          

Val Leu Glu Asp Pro Arg Arg His Gly Lys Ala Leu Val Gly Asn Arg 
        35                  40                  45              

Val Gly Gln Trp Arg Tyr Arg Ile Gly Asn Tyr Arg Val Ile Val Gln 
    50                  55                  60                  

Ile Val Asp Asp Glu Leu Val Val Ala Thr Leu Glu Val Gly His Arg 
65                  70                  75                  80  

Arg Asp Ile Tyr 
                

<210>   2457
<211>   300
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2457
ttgactgaac acctaaaaag taatacaatg gtgttaccat taaaaaaggg agcacaaaag   60
atgactacta ttacattaaa agtttctgaa gctgataaaa catttatgaa agcaatggct   120
aagtttgaag gagtttccct ttcggaactt attcgcacca aaactcttga agccctagaa   180
gatgaatacg atgctcgtgt ggcagattta gcctatcaag agtatttaga agacttggaa   240
aaaggagttg aacccattac ttgggaagaa atgatgcatg atttaggctt gaaggatgaa   300

<210>   2458
<211>   100
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903147 (6.E-53)

<400>   2458
Met Thr Glu His Leu Lys Ser Asn Thr Met Val Leu Pro Leu Lys Lys 
1               5                   10                  15      

Gly Ala Gln Lys Met Thr Thr Ile Thr Leu Lys Val Ser Glu Ala Asp 
            20                  25                  30          

Lys Thr Phe Met Lys Ala Met Ala Lys Phe Glu Gly Val Ser Leu Ser 
        35                  40                  45              

Glu Leu Ile Arg Thr Lys Thr Leu Glu Ala Leu Glu Asp Glu Tyr Asp 
    50                  55                  60                  

Ala Arg Val Ala Asp Leu Ala Tyr Gln Glu Tyr Leu Glu Asp Leu Glu 
65                  70                  75                  80  

Lys Gly Val Glu Pro Ile Thr Trp Glu Glu Met Met His Asp Leu Gly 
                85                  90                  95      

Leu Lys Asp Glu 
            100 

<210>   2459
<211>   807
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2459
atgagtgaaa taggctttaa atacagtatt ttagcgtcgg gttccagtgg aaattctttt   60
tatctggaaa cctcaaaaaa gaagctttta gtagatgcag gcttgtctgg caagaaaatt   120
accagtctgc tagctgaaat taaccgtaag ccagaagacc tggatgccat cttgattacc   180
catgagcatt cagatcatat ccatggagta ggcgttttgg ctcgcaagta tggtatggat   240
ctttatgcca atgaaaagac ctggcaagct atggaaaata gtaaatatct tggcaaggtg   300
gattcttcgc aaaagcatat ttttgaaatg ggtaaaacca aaacctttgg agatatcgac   360
atcgagagtt ttggtgtaag ccatgatgca gtcgcaccgc agttctatcg ctttatgaag   420
gatgataaga gttttgtcct cttgacagat acaggttatg tcagtgaccg tatggcgggc   480
attgtcgaaa atgcggatgg ttatcttatc gaggccaacc atgatgtaga gattttgcga   540
tcaggttctt acgcttggcg actcaaacaa cgaatcctat ctgaccttgg tcacctttct   600
aacgaggacg gtgctgaagc tatgattcgg acgctaggaa atcgtactaa gaagatttac   660
cttgggcatt tatctaagga aaacaatatc aaggaactgg ctcatatgac catggtcaat   720
cagctggctc aagctgatct gggagtcgga gtagacttta aggtttatga tacctcacca   780
gataccgcaa caccattgac agagata                                       807

<210>   2460
<211>   269
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   vicX protein (vicX)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903148 (e-154)

<400>   2460
Met Ser Glu Ile Gly Phe Lys Tyr Ser Ile Leu Ala Ser Gly Ser Ser 
1               5                   10                  15      

Gly Asn Ser Phe Tyr Leu Glu Thr Ser Lys Lys Lys Leu Leu Val Asp 
            20                  25                  30          

Ala Gly Leu Ser Gly Lys Lys Ile Thr Ser Leu Leu Ala Glu Ile Asn 
        35                  40                  45              

Arg Lys Pro Glu Asp Leu Asp Ala Ile Leu Ile Thr His Glu His Ser 
    50                  55                  60                  

Asp His Ile His Gly Val Gly Val Leu Ala Arg Lys Tyr Gly Met Asp 
65                  70                  75                  80  

Leu Tyr Ala Asn Glu Lys Thr Trp Gln Ala Met Glu Asn Ser Lys Tyr 
                85                  90                  95      

Leu Gly Lys Val Asp Ser Ser Gln Lys His Ile Phe Glu Met Gly Lys 
            100                 105                 110         

Thr Lys Thr Phe Gly Asp Ile Asp Ile Glu Ser Phe Gly Val Ser His 
        115                 120                 125             

Asp Ala Val Ala Pro Gln Phe Tyr Arg Phe Met Lys Asp Asp Lys Ser 
    130                 135                 140                 

Phe Val Leu Leu Thr Asp Thr Gly Tyr Val Ser Asp Arg Met Ala Gly 
145                 150                 155                 160 

Ile Val Glu Asn Ala Asp Gly Tyr Leu Ile Glu Ala Asn His Asp Val 
                165                 170                 175     

Glu Ile Leu Arg Ser Gly Ser Tyr Ala Trp Arg Leu Lys Gln Arg Ile 
            180                 185                 190         

Leu Ser Asp Leu Gly His Leu Ser Asn Glu Asp Gly Ala Glu Ala Met 
        195                 200                 205             

Ile Arg Thr Leu Gly Asn Arg Thr Lys Lys Ile Tyr Leu Gly His Leu 
    210                 215                 220                 

Ser Lys Glu Asn Asn Ile Lys Glu Leu Ala His Met Thr Met Val Asn 
225                 230                 235                 240 

Gln Leu Ala Gln Ala Asp Leu Gly Val Gly Val Asp Phe Lys Val Tyr 
                245                 250                 255     

Asp Thr Ser Pro Asp Thr Ala Thr Pro Leu Thr Glu Ile 
            260                 265                 

<210>   2461
<211>   1347
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2461
atgcttgatt tactgaaaca aaccattttt accagagatt ttatctttat cctgattttg   60
ttaggtttca tccttgttgt gaccctctta ttactggaaa atagacgtga taatattcag   120
ttgaagcaag tcaatcaaaa ggttaaagat ttgattgcag gagattattc caaggttctt   180
gatatgcaag gtgggtctga aatcaccaat attaccaata atttgaatga cttgtcggag   240
gttattcgtc tcactcagga aaatctagaa caagagagta agaggctaaa tagtattctg   300
ttttatatga cagatggggt tcttgcgact aaccgtcggg gtcagattat catgattaac   360
gatacagcca agaagcaact ggggttggtt aaggaagatg ttctgaatag aagcattttg   420
gaattgctca agatagaaga aaactatgaa ttgcgtgatt tgattaccca aagtccagaa   480
ttgttgctag attcccaaga tatcaatggc gaatatttga accttcgagt tcgctttgcc   540
ttgatacgtc gagagtctgg ctttatttca ggtttggtgg ctgttttgca tgatacgacg   600
gagcaggaga aggaagaacg cgaacgaaga ctctttgttt ccaatgttag ccatgagtta   660
cggactcctc tgactagcgt aaaatcctat cttgaagcct tggatgaggg ggctttgtgt   720
gaaactgtag caccagactt tatcaaggtt tctcttgatg agaccaaccg tatgatgcgc   780
atggtgacgg atctcctcca tctttcacgt attgataatg ctaccagtca cctagatgtg   840
gaactgatta acttcactgc ttttattacc tttatcctca atcgttttga caagatgaaa   900
ggacaggaaa aggagaaaaa atatgagttg gtgagagatt atcccatcaa ttctatctgg   960
atggaaattg atacagataa gatgacgcag gttgtcgaca atattttaaa taatgctatt   1020
aagtattcgc cagatggggg taaaatcact gtcagaatga agacaactga agaccagatg   1080
attttatcca tttctgacca cggtttgggg attcctaagc aggatttacc acgtatcttt   1140
gaccgtttct atcgtgtgga tcgtgctaga agtcgtgcac aaggtggtac aggtctagga   1200
ctgtctatcg ctaaagaaat tatcaaacaa cataagggct ttatttgggc caagagtgaa   1260
tacggcaagg gttcaacctt taccattgta ctcccttatg ataaggatgc agtgaaagaa   1320
gaagtatggg aggatgaagt agaagac                                       1347

<210>   2462
<211>   449
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensory box sensor histidine kinase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903149 (0.E+01)

<400>   2462
Met Leu Asp Leu Leu Lys Gln Thr Ile Phe Thr Arg Asp Phe Ile Phe 
1               5                   10                  15      

Ile Leu Ile Leu Leu Gly Phe Ile Leu Val Val Thr Leu Leu Leu Leu 
            20                  25                  30          

Glu Asn Arg Arg Asp Asn Ile Gln Leu Lys Gln Val Asn Gln Lys Val 
        35                  40                  45              

Lys Asp Leu Ile Ala Gly Asp Tyr Ser Lys Val Leu Asp Met Gln Gly 
    50                  55                  60                  

Gly Ser Glu Ile Thr Asn Ile Thr Asn Asn Leu Asn Asp Leu Ser Glu 
65                  70                  75                  80  

Val Ile Arg Leu Thr Gln Glu Asn Leu Glu Gln Glu Ser Lys Arg Leu 
                85                  90                  95      

Asn Ser Ile Leu Phe Tyr Met Thr Asp Gly Val Leu Ala Thr Asn Arg 
            100                 105                 110         

Arg Gly Gln Ile Ile Met Ile Asn Asp Thr Ala Lys Lys Gln Leu Gly 
        115                 120                 125             

Leu Val Lys Glu Asp Val Leu Asn Arg Ser Ile Leu Glu Leu Leu Lys 
    130                 135                 140                 

Ile Glu Glu Asn Tyr Glu Leu Arg Asp Leu Ile Thr Gln Ser Pro Glu 
145                 150                 155                 160 

Leu Leu Leu Asp Ser Gln Asp Ile Asn Gly Glu Tyr Leu Asn Leu Arg 
                165                 170                 175     

Val Arg Phe Ala Leu Ile Arg Arg Glu Ser Gly Phe Ile Ser Gly Leu 
            180                 185                 190         

Val Ala Val Leu His Asp Thr Thr Glu Gln Glu Lys Glu Glu Arg Glu 
        195                 200                 205             

Arg Arg Leu Phe Val Ser Asn Val Ser His Glu Leu Arg Thr Pro Leu 
    210                 215                 220                 

Thr Ser Val Lys Ser Tyr Leu Glu Ala Leu Asp Glu Gly Ala Leu Cys 
225                 230                 235                 240 

Glu Thr Val Ala Pro Asp Phe Ile Lys Val Ser Leu Asp Glu Thr Asn 
                245                 250                 255     

Arg Met Met Arg Met Val Thr Asp Leu Leu His Leu Ser Arg Ile Asp 
            260                 265                 270         

Asn Ala Thr Ser His Leu Asp Val Glu Leu Ile Asn Phe Thr Ala Phe 
        275                 280                 285             

Ile Thr Phe Ile Leu Asn Arg Phe Asp Lys Met Lys Gly Gln Glu Lys 
    290                 295                 300                 

Glu Lys Lys Tyr Glu Leu Val Arg Asp Tyr Pro Ile Asn Ser Ile Trp 
305                 310                 315                 320 

Met Glu Ile Asp Thr Asp Lys Met Thr Gln Val Val Asp Asn Ile Leu 
                325                 330                 335     

Asn Asn Ala Ile Lys Tyr Ser Pro Asp Gly Gly Lys Ile Thr Val Arg 
            340                 345                 350         

Met Lys Thr Thr Glu Asp Gln Met Ile Leu Ser Ile Ser Asp His Gly 
        355                 360                 365             

Leu Gly Ile Pro Lys Gln Asp Leu Pro Arg Ile Phe Asp Arg Phe Tyr 
    370                 375                 380                 

Arg Val Asp Arg Ala Arg Ser Arg Ala Gln Gly Gly Thr Gly Leu Gly 
385                 390                 395                 400 

Leu Ser Ile Ala Lys Glu Ile Ile Lys Gln His Lys Gly Phe Ile Trp 
                405                 410                 415     

Ala Lys Ser Glu Tyr Gly Lys Gly Ser Thr Phe Thr Ile Val Leu Pro 
            420                 425                 430         

Tyr Asp Lys Asp Ala Val Lys Glu Glu Val Trp Glu Asp Glu Val Glu 
        435                 440                 445             

Asp 
    

<210>   2463
<211>   702
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2463
atgaaaaaaa tactaattgt agatgatgag aaaccaatct cggatattat caagtttaat   60
atgaccaagg aaggttacga agttgtaact gcttttaatg gtcgtgaagc gctagagcaa   120
tttgaagcag agcaaccaga tattattatt ctggatttga tgcttccaga aattgatggt   180
ttagaagttg ctaagaccat tcgtaagaca agcagtgtgc ccattcttat gctttcagcc   240
aaagatagtg aatttgataa ggttatcggt ttggaacttg gggcagatga ctatgtaaca   300
aaacccttct ccaatcgtga gttgcaggcg cgtgttaaag ctcttctgcg tcgttctcaa   360
cctatgccag tagatggtca ggaagcagat agtaaacctc aacctatcca aattggggat   420
ttagaaattg ttccagacgc ctacgtggct aaaaaatatg gcgaagaact agacttaacc   480
catcgtgaat ttgagctttt gtatcattta gcatcgcata caggtcaagt catcacgcgc   540
gaacacttgc ttgagactgt ctggggttat gactattttg gtgatgtccg tacagttgat   600
gtgactgtac gacgtctgcg tgagaagatt gaagatacgc ccagccgacc agagtatatc   660
ttgacgcgcc gtggtgtagg gtattacatg agaaataatg ct                      702

<210>   2464
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903150 (e-132)

<400>   2464
Met Lys Lys Ile Leu Ile Val Asp Asp Glu Lys Pro Ile Ser Asp Ile 
1               5                   10                  15      

Ile Lys Phe Asn Met Thr Lys Glu Gly Tyr Glu Val Val Thr Ala Phe 
            20                  25                  30          

Asn Gly Arg Glu Ala Leu Glu Gln Phe Glu Ala Glu Gln Pro Asp Ile 
        35                  40                  45              

Ile Ile Leu Asp Leu Met Leu Pro Glu Ile Asp Gly Leu Glu Val Ala 
    50                  55                  60                  

Lys Thr Ile Arg Lys Thr Ser Ser Val Pro Ile Leu Met Leu Ser Ala 
65                  70                  75                  80  

Lys Asp Ser Glu Phe Asp Lys Val Ile Gly Leu Glu Leu Gly Ala Asp 
                85                  90                  95      

Asp Tyr Val Thr Lys Pro Phe Ser Asn Arg Glu Leu Gln Ala Arg Val 
            100                 105                 110         

Lys Ala Leu Leu Arg Arg Ser Gln Pro Met Pro Val Asp Gly Gln Glu 
        115                 120                 125             

Ala Asp Ser Lys Pro Gln Pro Ile Gln Ile Gly Asp Leu Glu Ile Val 
    130                 135                 140                 

Pro Asp Ala Tyr Val Ala Lys Lys Tyr Gly Glu Glu Leu Asp Leu Thr 
145                 150                 155                 160 

His Arg Glu Phe Glu Leu Leu Tyr His Leu Ala Ser His Thr Gly Gln 
                165                 170                 175     

Val Ile Thr Arg Glu His Leu Leu Glu Thr Val Trp Gly Tyr Asp Tyr 
            180                 185                 190         

Phe Gly Asp Val Arg Thr Val Asp Val Thr Val Arg Arg Leu Arg Glu 
        195                 200                 205             

Lys Ile Glu Asp Thr Pro Ser Arg Pro Glu Tyr Ile Leu Thr Arg Arg 
    210                 215                 220                 

Gly Val Gly Tyr Tyr Met Arg Asn Asn Ala 
225                 230                 

<210>   2465
<211>   1173
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2465
atgttagatt tgaaagaata cggtatcgtc atgtggccgg aggagaaagt catttctttc   60
cgtgagaaac ttctcgcttg gtatgatgaa aacaaaagag atttgccttg gaggagaagt   120
aaaaatcctt atcacatctg ggtatctgaa atcatgcttc agcagaccag ggtggataca   180
gttatccctt actacgaaag atttttggac tggtttccaa ctgtcgaaag tctggcaact   240
gcgcctgagg agagtttact gaaagcttgg gagggcttgg gctattattc tcgagttcgc   300
aatatgcagg ctgcagccca gcagattatg actgactttg gtggccaatt tccaaatacc   360
tatgaaggaa tttccagctt gaaagggatt ggaccttaca cagcaggagc catttccagt   420
attgctttta acttgcctga gccagctgta gatggtaatg tcatgcgggt cttggcgcgt   480
ctgtttgaag tcaaccacga tattgggatt ccaagtaatc gaaaaatttt tcaggcaatg   540
atggagatct tgattaatcc ggatcgtccg ggtgatttta atcaagcctt gatggactta   600
gggtctgata ttgagtctcc tgtaaatccc agacctgaag aaagcccagt caaggacttt   660
agtgcggcat atcagaatgg aaccatggac cgttatccaa ttaaatctcc taagaaaaag   720
ccggttccta tttatcttaa agccttagtt gtgaaaaatt ctcaaggaca atttttactt   780
gaaaaaaatg aaagcgaaaa gctcttggca ggtttttggc atttcccctt tatagaagtt   840
gataactttt cgcaagaaga gcagtttgac ctctttcatc aggttgcgga agaaagtgtg   900
aactttggtc ccagtccaga agagagtttc cagcaggact atgacctaga tgttgattgg   960
cttgatgttt gttttgatac agtccagcat gtttttagtc atcgaaaatg gcatgtacag   1020
attgtagcag gtcaggtgag tgacttccat gatttttcag atagggaagt tcgctggctt   1080
tcaccagaag aattcaagaa ttacccactt gccaaacccc aacaaaaaat ctggcaggtt   1140
tatgcacaag ccaacttaga cagtagccaa gac                                1173

<210>   2466
<211>   391
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   A/G-specific adenine glycosylase (mutY)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903151 (0.E+01)

<400>   2466
Met Leu Asp Leu Lys Glu Tyr Gly Ile Val Met Trp Pro Glu Glu Lys 
1               5                   10                  15      

Val Ile Ser Phe Arg Glu Lys Leu Leu Ala Trp Tyr Asp Glu Asn Lys 
            20                  25                  30          

Arg Asp Leu Pro Trp Arg Arg Ser Lys Asn Pro Tyr His Ile Trp Val 
        35                  40                  45              

Ser Glu Ile Met Leu Gln Gln Thr Arg Val Asp Thr Val Ile Pro Tyr 
    50                  55                  60                  

Tyr Glu Arg Phe Leu Asp Trp Phe Pro Thr Val Glu Ser Leu Ala Thr 
65                  70                  75                  80  

Ala Pro Glu Glu Ser Leu Leu Lys Ala Trp Glu Gly Leu Gly Tyr Tyr 
                85                  90                  95      

Ser Arg Val Arg Asn Met Gln Ala Ala Ala Gln Gln Ile Met Thr Asp 
            100                 105                 110         

Phe Gly Gly Gln Phe Pro Asn Thr Tyr Glu Gly Ile Ser Ser Leu Lys 
        115                 120                 125             

Gly Ile Gly Pro Tyr Thr Ala Gly Ala Ile Ser Ser Ile Ala Phe Asn 
    130                 135                 140                 

Leu Pro Glu Pro Ala Val Asp Gly Asn Val Met Arg Val Leu Ala Arg 
145                 150                 155                 160 

Leu Phe Glu Val Asn His Asp Ile Gly Ile Pro Ser Asn Arg Lys Ile 
                165                 170                 175     

Phe Gln Ala Met Met Glu Ile Leu Ile Asn Pro Asp Arg Pro Gly Asp 
            180                 185                 190         

Phe Asn Gln Ala Leu Met Asp Leu Gly Ser Asp Ile Glu Ser Pro Val 
        195                 200                 205             

Asn Pro Arg Pro Glu Glu Ser Pro Val Lys Asp Phe Ser Ala Ala Tyr 
    210                 215                 220                 

Gln Asn Gly Thr Met Asp Arg Tyr Pro Ile Lys Ser Pro Lys Lys Lys 
225                 230                 235                 240 

Pro Val Pro Ile Tyr Leu Lys Ala Leu Val Val Lys Asn Ser Gln Gly 
                245                 250                 255     

Gln Phe Leu Leu Glu Lys Asn Glu Ser Glu Lys Leu Leu Ala Gly Phe 
            260                 265                 270         

Trp His Phe Pro Phe Ile Glu Val Asp Asn Phe Ser Gln Glu Glu Gln 
        275                 280                 285             

Phe Asp Leu Phe His Gln Val Ala Glu Glu Ser Val Asn Phe Gly Pro 
    290                 295                 300                 

Ser Pro Glu Glu Ser Phe Gln Gln Asp Tyr Asp Leu Asp Val Asp Trp 
305                 310                 315                 320 

Leu Asp Val Cys Phe Asp Thr Val Gln His Val Phe Ser His Arg Lys 
                325                 330                 335     

Trp His Val Gln Ile Val Ala Gly Gln Val Ser Asp Phe His Asp Phe 
            340                 345                 350         

Ser Asp Arg Glu Val Arg Trp Leu Ser Pro Glu Glu Phe Lys Asn Tyr 
        355                 360                 365             

Pro Leu Ala Lys Pro Gln Gln Lys Ile Trp Gln Val Tyr Ala Gln Ala 
    370                 375                 380                 

Asn Leu Asp Ser Ser Gln Asp 
385                 390     

<210>   2467
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2467
ttgaaattga ctttaagtga gtttggaaat aatatccaag ctcatttttt ctcagactgc   60
aagcagttca tcaataagat ttatactctt cgaaaatctc ttcaaactac gtcagcttca   120
ccttgccgta ggtatatgat actgactctg tcagttctat ccacaacctc aaaacagtgt   180
tttgagcaac ctgcggctag cttcctagtt tgctctttga ttttcattga gtataag      237

<210>   2468
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   2468
Met Lys Leu Thr Leu Ser Glu Phe Gly Asn Asn Ile Gln Ala His Phe 
1               5                   10                  15      

Phe Ser Asp Cys Lys Gln Phe Ile Asn Lys Ile Tyr Thr Leu Arg Lys 
            20                  25                  30          

Ser Leu Gln Thr Thr Ser Ala Ser Pro Cys Arg Arg Tyr Met Ile Leu 
        35                  40                  45              

Thr Leu Ser Val Leu Ser Thr Thr Ser Lys Gln Cys Phe Glu Gln Pro 
    50                  55                  60                  

Ala Ala Ser Phe Leu Val Cys Ser Leu Ile Phe Ile Glu Tyr Lys 
65                  70                  75                  

<210>   2469
<211>   1668
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2469
atgaaaacag atattgaaat cgcacagagt attgagttga agccaattgt tgatgttgta   60
gagaaacttg gtatttctta tgacgatttg gagttgtacg gaaagtacaa ggctaaactc   120
agctttgata aaattcgtgc agttgagagc aatccagtcg gtaaattgat cttggttact   180
gccatcaacc caacacctgc aggtgaagga aagtcgacgc ttaccattgg tcttgcggat   240
gccttgaaca agattggcaa gaaaaccatg attgctatcc gcgaaccgtc tcttggtcca   300
gtcatgggga tcaagggtgg tgctgctggt ggtgggtatg cacaagttct gccaatggaa   360
gacatcaacc tccactttac tggagatatg catgctatta caactgccaa caatgccctt   420
tctgccttga ttgacaacca cttgcaccaa gggaatgagc tgggaattga tcaacgtcgt   480
atcctctgga aacgcgttgt ggacttgaac gaccgtacgc tccgccatgt gactgttggt   540
cttggtggtc ctctaaacgg tattccacgt gaggatggtt ttgatattac agttgcttca   600
gaaatcatgg caattctttg cttggcaacg gacatcgagg acttgaaacg tcgtttggcg   660
aatatcgtta ttggttatcg ctatgaccgt acgcctgttt ctgtaggtga tttgcaggtt   720
gagggtgcct tggctttgat tttgaaggat gctattaagc caaacttggt tcagacaatt   780
tacggtacac ctgcctttgt acacggtggt ccatttgcca atatcgctca tggctgtaac   840
tctgttttgg cgacgacaac agcccttcac ttggctgatt acactgttac tgaagctggt   900
tttggtgcgg accttggtgc tgagaaattc cttgatatca agacaccaaa cttgccaaca   960
tctccagatg cagttgttat tgtcgcaacc cttcgtgccc ttaagatgaa tggtggtgtg   1020
gctaaagacg ctctgactga agaaaatgta gaggcagttc gtgcaggttt tgctaacttg   1080
aaacgccacg ttgaaaatat ccgtaagttc ggtattccag cagttgtagc tattaacgaa   1140
tttgtatctg atacagaagc tgaaattgca gccttaaaag aactctgtgc ctcaatcgat   1200
gtaccagttg aattggctag tgtctgggct gatggagcag aaggtggagt agcacttgcc   1260
gaaacagttg ttaagacaat tgctgaaaat ccagctaact ataaacgttt gtatgataat   1320
gacctttctg tccaagaaaa gattgaaaaa attgtcactg aaatctatcg tggtagcaaa   1380
gtgaactttg agaagaaagc tcaaacacaa attgctcaaa tcgttcaaaa cggttgggac   1440
aaattgccaa tctgtatggc taaaactcaa tacagtttct cagacaatcc aaatgcgctt   1500
ggagcaccag aaaactttga aattaccatt cgtgaattgg taccaaaatt aggtgcaggc   1560
ttcatcgttg ccttaactgg tgatgttatg accatgccag gtcttccaaa acgtccagca   1620
gctctcaaca tggatgttga aagcgatgga actgtactag gcttgttc                1668

<210>   2470
<211>   556
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   formate--tetrahydrofolate ligase (fhs)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903152 (0.E+01)

<400>   2470
Met Lys Thr Asp Ile Glu Ile Ala Gln Ser Ile Glu Leu Lys Pro Ile 
1               5                   10                  15      

Val Asp Val Val Glu Lys Leu Gly Ile Ser Tyr Asp Asp Leu Glu Leu 
            20                  25                  30          

Tyr Gly Lys Tyr Lys Ala Lys Leu Ser Phe Asp Lys Ile Arg Ala Val 
        35                  40                  45              

Glu Ser Asn Pro Val Gly Lys Leu Ile Leu Val Thr Ala Ile Asn Pro 
    50                  55                  60                  

Thr Pro Ala Gly Glu Gly Lys Ser Thr Leu Thr Ile Gly Leu Ala Asp 
65                  70                  75                  80  

Ala Leu Asn Lys Ile Gly Lys Lys Thr Met Ile Ala Ile Arg Glu Pro 
                85                  90                  95      

Ser Leu Gly Pro Val Met Gly Ile Lys Gly Gly Ala Ala Gly Gly Gly 
            100                 105                 110         

Tyr Ala Gln Val Leu Pro Met Glu Asp Ile Asn Leu His Phe Thr Gly 
        115                 120                 125             

Asp Met His Ala Ile Thr Thr Ala Asn Asn Ala Leu Ser Ala Leu Ile 
    130                 135                 140                 

Asp Asn His Leu His Gln Gly Asn Glu Leu Gly Ile Asp Gln Arg Arg 
145                 150                 155                 160 

Ile Leu Trp Lys Arg Val Val Asp Leu Asn Asp Arg Thr Leu Arg His 
                165                 170                 175     

Val Thr Val Gly Leu Gly Gly Pro Leu Asn Gly Ile Pro Arg Glu Asp 
            180                 185                 190         

Gly Phe Asp Ile Thr Val Ala Ser Glu Ile Met Ala Ile Leu Cys Leu 
        195                 200                 205             

Ala Thr Asp Ile Glu Asp Leu Lys Arg Arg Leu Ala Asn Ile Val Ile 
    210                 215                 220                 

Gly Tyr Arg Tyr Asp Arg Thr Pro Val Ser Val Gly Asp Leu Gln Val 
225                 230                 235                 240 

Glu Gly Ala Leu Ala Leu Ile Leu Lys Asp Ala Ile Lys Pro Asn Leu 
                245                 250                 255     

Val Gln Thr Ile Tyr Gly Thr Pro Ala Phe Val His Gly Gly Pro Phe 
            260                 265                 270         

Ala Asn Ile Ala His Gly Cys Asn Ser Val Leu Ala Thr Thr Thr Ala 

        275                 280                 285             

Leu His Leu Ala Asp Tyr Thr Val Thr Glu Ala Gly Phe Gly Ala Asp 
    290                 295                 300                 

Leu Gly Ala Glu Lys Phe Leu Asp Ile Lys Thr Pro Asn Leu Pro Thr 
305                 310                 315                 320 

Ser Pro Asp Ala Val Val Ile Val Ala Thr Leu Arg Ala Leu Lys Met 
                325                 330                 335     

Asn Gly Gly Val Ala Lys Asp Ala Leu Thr Glu Glu Asn Val Glu Ala 
            340                 345                 350         

Val Arg Ala Gly Phe Ala Asn Leu Lys Arg His Val Glu Asn Ile Arg 
        355                 360                 365             

Lys Phe Gly Ile Pro Ala Val Val Ala Ile Asn Glu Phe Val Ser Asp 
    370                 375                 380                 

Thr Glu Ala Glu Ile Ala Ala Leu Lys Glu Leu Cys Ala Ser Ile Asp 
385                 390                 395                 400 

Val Pro Val Glu Leu Ala Ser Val Trp Ala Asp Gly Ala Glu Gly Gly 
                405                 410                 415     

Val Ala Leu Ala Glu Thr Val Val Lys Thr Ile Ala Glu Asn Pro Ala 
            420                 425                 430         

Asn Tyr Lys Arg Leu Tyr Asp Asn Asp Leu Ser Val Gln Glu Lys Ile 
        435                 440                 445             

Glu Lys Ile Val Thr Glu Ile Tyr Arg Gly Ser Lys Val Asn Phe Glu 
    450                 455                 460                 

Lys Lys Ala Gln Thr Gln Ile Ala Gln Ile Val Gln Asn Gly Trp Asp 
465                 470                 475                 480 

Lys Leu Pro Ile Cys Met Ala Lys Thr Gln Tyr Ser Phe Ser Asp Asn 
                485                 490                 495     

Pro Asn Ala Leu Gly Ala Pro Glu Asn Phe Glu Ile Thr Ile Arg Glu 
            500                 505                 510         

Leu Val Pro Lys Leu Gly Ala Gly Phe Ile Val Ala Leu Thr Gly Asp 
        515                 520                 525             

Val Met Thr Met Pro Gly Leu Pro Lys Arg Pro Ala Ala Leu Asn Met 
    530                 535                 540                 

Asp Val Glu Ser Asp Gly Thr Val Leu Gly Leu Phe 
545                 550                 555     

<210>   2471
<211>   702
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2471
gtgtacaata gtgctatgaa aattttagtt acatcgggcg gtaccagtga agctatcgat   60
agcgtccgct ctatcactaa ccattctaca ggtcacttgg ggaaaattat cacagagact   120
ttgctttctg cagggtatga agtttgttta attacgacaa aacgagctct gaagccagag   180
cctcatccta acctaagtat tcgagaaatt accaatacca aggaccttct aatagaaatg   240
caagaacgtg ttcaggatta tcaggtcttg atccactcaa tggctgtttc tgactacact   300
cctgtttata tgacagggct tgaggaagtt caggctagct ccaatctaaa agaattttta   360
agcaagcaaa atcatcaggc caagatttct tcaactgatg aggttcaggt tttgttcctt   420
aaaaagacac ccaaaatcat atccctagtc aaggaatgga atcctactat tcatctgatt   480
ggtttcaaac tgctggttga tgttaccgaa gatcatctgg ttgacattgc acgaaaaagt   540
cttatcaaga atcaagcaga tttaatcatc gcgaatgacc tgactcaaat ttcagcagat   600
cagcaccgag ctatatttgt tgagaaaaat cagcttcaaa cagtccagac taaagaagaa   660
attgcagaac tcctccttga aaaaattcaa gcctatcatt ct                      702

<210>   2472
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903153 (e-125)

<400>   2472
Met Tyr Asn Ser Ala Met Lys Ile Leu Val Thr Ser Gly Gly Thr Ser 
1               5                   10                  15      

Glu Ala Ile Asp Ser Val Arg Ser Ile Thr Asn His Ser Thr Gly His 
            20                  25                  30          

Leu Gly Lys Ile Ile Thr Glu Thr Leu Leu Ser Ala Gly Tyr Glu Val 
        35                  40                  45              

Cys Leu Ile Thr Thr Lys Arg Ala Leu Lys Pro Glu Pro His Pro Asn 
    50                  55                  60                  

Leu Ser Ile Arg Glu Ile Thr Asn Thr Lys Asp Leu Leu Ile Glu Met 
65                  70                  75                  80  

Gln Glu Arg Val Gln Asp Tyr Gln Val Leu Ile His Ser Met Ala Val 
                85                  90                  95      

Ser Asp Tyr Thr Pro Val Tyr Met Thr Gly Leu Glu Glu Val Gln Ala 
            100                 105                 110         

Ser Ser Asn Leu Lys Glu Phe Leu Ser Lys Gln Asn His Gln Ala Lys 
        115                 120                 125             

Ile Ser Ser Thr Asp Glu Val Gln Val Leu Phe Leu Lys Lys Thr Pro 
    130                 135                 140                 

Lys Ile Ile Ser Leu Val Lys Glu Trp Asn Pro Thr Ile His Leu Ile 
145                 150                 155                 160 

Gly Phe Lys Leu Leu Val Asp Val Thr Glu Asp His Leu Val Asp Ile 
                165                 170                 175     

Ala Arg Lys Ser Leu Ile Lys Asn Gln Ala Asp Leu Ile Ile Ala Asn 
            180                 185                 190         

Asp Leu Thr Gln Ile Ser Ala Asp Gln His Arg Ala Ile Phe Val Glu 
        195                 200                 205             

Lys Asn Gln Leu Gln Thr Val Gln Thr Lys Glu Glu Ile Ala Glu Leu 
    210                 215                 220                 

Leu Leu Glu Lys Ile Gln Ala Tyr His Ser 
225                 230                 

<210>   2473
<211>   549
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2473
atggcaaaca ttctcttggc tgtaacgggt tcaatcgcct cttataagtc ggcagattta   60
gtcagttctc taaaaaaaca aggccatcaa gtcactgtct taatgactca ggctgctaca   120
gagtttatcc aacctttgac actacaggta ctctcacaga atcctgtcca cttggatgtc   180
atgaaggaac cctatcctga tcaggtcaat catatcgaac ttggaaaaaa agcagattta   240
tttatcgtgg tacctgcaac tgctaacact attgcaaaac tagctcacgg atttgcggac   300
aacatggtaa ccagtacagc tctagcccta ccaagtcata ttcccaaact aatagctcct   360
gctatgaata caaaaatgta tgaccatcca gtaactcaga ataatctgaa aacattagaa   420
acctacggct atcagctgat tgctcctaag gaatccctac tagcttgtgg agaccacgga   480
cgaggagctt tagctgacct cacaattatt ttagaaagaa taaaggaaac tatcgatgaa   540
aaaacgctc                                                           549

<210>   2474
<211>   183
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   flavoprotein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903154 (e-101)

<400>   2474
Met Ala Asn Ile Leu Leu Ala Val Thr Gly Ser Ile Ala Ser Tyr Lys 
1               5                   10                  15      

Ser Ala Asp Leu Val Ser Ser Leu Lys Lys Gln Gly His Gln Val Thr 
            20                  25                  30          

Val Leu Met Thr Gln Ala Ala Thr Glu Phe Ile Gln Pro Leu Thr Leu 
        35                  40                  45              

Gln Val Leu Ser Gln Asn Pro Val His Leu Asp Val Met Lys Glu Pro 
    50                  55                  60                  

Tyr Pro Asp Gln Val Asn His Ile Glu Leu Gly Lys Lys Ala Asp Leu 
65                  70                  75                  80  

Phe Ile Val Val Pro Ala Thr Ala Asn Thr Ile Ala Lys Leu Ala His 
                85                  90                  95      

Gly Phe Ala Asp Asn Met Val Thr Ser Thr Ala Leu Ala Leu Pro Ser 
            100                 105                 110         

His Ile Pro Lys Leu Ile Ala Pro Ala Met Asn Thr Lys Met Tyr Asp 
        115                 120                 125             

His Pro Val Thr Gln Asn Asn Leu Lys Thr Leu Glu Thr Tyr Gly Tyr 
    130                 135                 140                 

Gln Leu Ile Ala Pro Lys Glu Ser Leu Leu Ala Cys Gly Asp His Gly 
145                 150                 155                 160 

Arg Gly Ala Leu Ala Asp Leu Thr Ile Ile Leu Glu Arg Ile Lys Glu 
                165                 170                 175     

Thr Ile Asp Glu Lys Thr Leu 
            180             

<210>   2475
<211>   561
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   2475
atgaaaaaac gctctaatat tgcacccatt gctatctttt ttgctaccat gctcgtgata   60
cactttctga gctcacttat ctttaacctt tttccatttc caatcaaacc gaccattgtt   120
catattcctg tcattattgc cagcattatt tatggtccac gagttggggt tacacttgga   180
tttttgatgg gattacttag cttgacggtt aacacgatta cgattctacc gacaagctac   240
ctcttctctc ccttcgtacc aaacggaaac atctactcag ctatcattgc catcgtccca   300
cgtattttga ttggtttaac tccttactta gtctataaac tgatgaaaaa caagactggt   360
ctgattttag ctggagccct tggttccttg acaaatacta tctttgtcct tggaggaatc   420
ttcttcctat ttggaaatgt ttataatgga aatatccaac ttcttctggc aaccgttatc   480
tcaacaaatt caattgctga attggtcatt tctgcaattc taaccctagc cattgttcca   540
cgactacaaa ccttgaaaaa a                                             561

<210>   2476
<211>   187
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903155 (e-100)

<400>   2476
Met Lys Lys Arg Ser Asn Ile Ala Pro Ile Ala Ile Phe Phe Ala Thr 
1               5                   10                  15      

Met Leu Val Ile His Phe Leu Ser Ser Leu Ile Phe Asn Leu Phe Pro 
            20                  25                  30          

Phe Pro Ile Lys Pro Thr Ile Val His Ile Pro Val Ile Ile Ala Ser 
        35                  40                  45              

Ile Ile Tyr Gly Pro Arg Val Gly Val Thr Leu Gly Phe Leu Met Gly 
    50                  55                  60                  

Leu Leu Ser Leu Thr Val Asn Thr Ile Thr Ile Leu Pro Thr Ser Tyr 
65                  70                  75                  80  

Leu Phe Ser Pro Phe Val Pro Asn Gly Asn Ile Tyr Ser Ala Ile Ile 
                85                  90                  95      

Ala Ile Val Pro Arg Ile Leu Ile Gly Leu Thr Pro Tyr Leu Val Tyr 
            100                 105                 110         

Lys Leu Met Lys Asn Lys Thr Gly Leu Ile Leu Ala Gly Ala Leu Gly 
        115                 120                 125             

Ser Leu Thr Asn Thr Ile Phe Val Leu Gly Gly Ile Phe Phe Leu Phe 
    130                 135                 140                 

Gly Asn Val Tyr Asn Gly Asn Ile Gln Leu Leu Leu Ala Thr Val Ile 
145                 150                 155                 160 

Ser Thr Asn Ser Ile Ala Glu Leu Val Ile Ser Ala Ile Leu Thr Leu 
                165                 170                 175     

Ala Ile Val Pro Arg Leu Gln Thr Leu Lys Lys 
            180                 185         

<210>   2477
<211>   579
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2477
ttgtctggtt tattgtacca tactagtgta tatgcagtta aaaaggagat tcttgtgaat   60
acacggaaaa agacacaatt tatgacaatg acagcccttt taacggctat tgcgattttg   120
attccaattg ttatgccttt caagattgtc attccacctg cttcctatac tttggggagc   180
cacatcgcta tttttatagc catgttcttg tcgcccttga tggcagtttt tgtcatccta   240
gcctctagtt ttggattttt gatggctggc tatcccatgg ttatcgtttt tcgggctttt   300
tcccatatat cttttggtgc tttaggagct ctttacctac aaaaattccc cgatacccta   360
gataaaccaa aatcttcctg gattttcaac tttgttttgg ctgttgttca tgcccttgct   420
gaagtattgg cctgtgtcgt tttttacgca acttctggta ccaatgtaga aaatatgttt   480
tatgttctat ttgtactagt tggatttggt acaattatcc atagtatggt agactataca   540
ttagcactag ctgtctataa agtgcttcga aaacgccgt                          579

<210>   2478
<211>   193
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903156 (e-105)

<400>   2478
Met Ser Gly Leu Leu Tyr His Thr Ser Val Tyr Ala Val Lys Lys Glu 
1               5                   10                  15      

Ile Leu Val Asn Thr Arg Lys Lys Thr Gln Phe Met Thr Met Thr Ala 
            20                  25                  30          

Leu Leu Thr Ala Ile Ala Ile Leu Ile Pro Ile Val Met Pro Phe Lys 
        35                  40                  45              

Ile Val Ile Pro Pro Ala Ser Tyr Thr Leu Gly Ser His Ile Ala Ile 
    50                  55                  60                  

Phe Ile Ala Met Phe Leu Ser Pro Leu Met Ala Val Phe Val Ile Leu 
65                  70                  75                  80  

Ala Ser Ser Phe Gly Phe Leu Met Ala Gly Tyr Pro Met Val Ile Val 
                85                  90                  95      

Phe Arg Ala Phe Ser His Ile Ser Phe Gly Ala Leu Gly Ala Leu Tyr 
            100                 105                 110         

Leu Gln Lys Phe Pro Asp Thr Leu Asp Lys Pro Lys Ser Ser Trp Ile 
        115                 120                 125             

Phe Asn Phe Val Leu Ala Val Val His Ala Leu Ala Glu Val Leu Ala 
    130                 135                 140                 

Cys Val Val Phe Tyr Ala Thr Ser Gly Thr Asn Val Glu Asn Met Phe 
145                 150                 155                 160 

Tyr Val Leu Phe Val Leu Val Gly Phe Gly Thr Ile Ile His Ser Met 
                165                 170                 175     

Val Asp Tyr Thr Leu Ala Leu Ala Val Tyr Lys Val Leu Arg Lys Arg 
            180                 185                 190         

Arg 
    

<210>   2479
<211>   513
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2479
atgacaaaag atcgcaaaca agccctgctc caactcttga aagaagctcc taaagccctc   60
aatggccaaa gattagctga gcactttcat gtcactcgac aagttattgt tcaagatatt   120
gcaattttaa gagctgatgg atctccaatt ctatctacca atcgtggtta tatctataaa   180
gatgctaatg caaatactta tcatcacaaa ttatttaagg tcaagcatga agttgaagaa   240
attggacgag aattacttgc tatcgtagat aatggtggtc gcgttcaaaa tatcttgatt   300
gatcatcctg tttatggaga gattgaaacc ttactaaaac tgacctgtcg ccgcgacgtg   360
caacattttc tagaacaagt tgaacgttct gactttaagc caatttctga gttaacagat   420
ggtattcatt atcacctagt tgaagccgag acacaacaag acctccacta tatcgaggag   480
gccttggatc agctaggtta tttagtaaaa gac                                513

<210>   2480
<211>   171
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, biotin repressor family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903157 (9.E-88)

<400>   2480
Met Thr Lys Asp Arg Lys Gln Ala Leu Leu Gln Leu Leu Lys Glu Ala 
1               5                   10                  15      

Pro Lys Ala Leu Asn Gly Gln Arg Leu Ala Glu His Phe His Val Thr 
            20                  25                  30          

Arg Gln Val Ile Val Gln Asp Ile Ala Ile Leu Arg Ala Asp Gly Ser 
        35                  40                  45              

Pro Ile Leu Ser Thr Asn Arg Gly Tyr Ile Tyr Lys Asp Ala Asn Ala 
    50                  55                  60                  

Asn Thr Tyr His His Lys Leu Phe Lys Val Lys His Glu Val Glu Glu 
65                  70                  75                  80  

Ile Gly Arg Glu Leu Leu Ala Ile Val Asp Asn Gly Gly Arg Val Gln 
                85                  90                  95      

Asn Ile Leu Ile Asp His Pro Val Tyr Gly Glu Ile Glu Thr Leu Leu 
            100                 105                 110         

Lys Leu Thr Cys Arg Arg Asp Val Gln His Phe Leu Glu Gln Val Glu 
        115                 120                 125             

Arg Ser Asp Phe Lys Pro Ile Ser Glu Leu Thr Asp Gly Ile His Tyr 
    130                 135                 140                 

His Leu Val Glu Ala Glu Thr Gln Gln Asp Leu His Tyr Ile Glu Glu 
145                 150                 155                 160 

Ala Leu Asp Gln Leu Gly Tyr Leu Val Lys Asp 
                165                 170     

<210>   2481
<211>   465
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2481
atgtcccgtt cccaattaac aattttaaca aatatctgtc tgattgaaga cctcgaaact   60
cagcgcgtgg tgatgcagta tcgcgcccct gaaaacaatc gctggtctgg ttatgccttt   120
cctggaggtc atgtagaaaa tgatgaggct tttgcggagt ctgtcattcg tgaaatctac   180
gaagaaacag ggttgactat ccaaaatcct caacttgtcg gcattaaaaa ttggccacta   240
gatacaggtg ggcgctatat tgtcatttgt tataaggcga ctgagttctc tggtaccctt   300
caatcttcag aagagggaga agtttcttgg gtgcaaaaag accagattcc aaacttaaat   360
ctggcctatg atatgctacc attgatggaa atgatggaag ctcccgacaa gtcagagttt   420
ttctaccctc gccgtacaga agacgattgg gaaaagaaaa tcttc                   465

<210>   2482
<211>   155
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MutT/nudix family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903158 (7.E-90)

<400>   2482
Met Ser Arg Ser Gln Leu Thr Ile Leu Thr Asn Ile Cys Leu Ile Glu 
1               5                   10                  15      

Asp Leu Glu Thr Gln Arg Val Val Met Gln Tyr Arg Ala Pro Glu Asn 
            20                  25                  30          

Asn Arg Trp Ser Gly Tyr Ala Phe Pro Gly Gly His Val Glu Asn Asp 
        35                  40                  45              

Glu Ala Phe Ala Glu Ser Val Ile Arg Glu Ile Tyr Glu Glu Thr Gly 
    50                  55                  60                  

Leu Thr Ile Gln Asn Pro Gln Leu Val Gly Ile Lys Asn Trp Pro Leu 
65                  70                  75                  80  

Asp Thr Gly Gly Arg Tyr Ile Val Ile Cys Tyr Lys Ala Thr Glu Phe 
                85                  90                  95      

Ser Gly Thr Leu Gln Ser Ser Glu Glu Gly Glu Val Ser Trp Val Gln 
            100                 105                 110         

Lys Asp Gln Ile Pro Asn Leu Asn Leu Ala Tyr Asp Met Leu Pro Leu 
        115                 120                 125             

Met Glu Met Met Glu Ala Pro Asp Lys Ser Glu Phe Phe Tyr Pro Arg 
    130                 135                 140                 

Arg Thr Glu Asp Asp Trp Glu Lys Lys Ile Phe 
145                 150                 155 

<210>   2483
<211>   486
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2483
atgacggtta ttatcaaatc aatggaaact cctgaagaga tagaaggtaa atccttcgtt   60
cactggcaaa cgtggagaga ggcttatgat gaccttttgc ctgcggaatt tcaggagaca   120
atgacattag aaagatgtcg actctttagt caaaagtatc cagaaaatac attgattgcg   180
atggatggtg tgaagatagt tggttttata agttatggca actgtcgtga tgagactatt   240
caagctggtg aaattattgc tttatatgtt ttaaaagact attatggaaa aggaatcgca   300
caaaagttag tgaaagcagc tttgactgat cttaatcatt tttctgaaat tttcttatgg   360
gtattgaaag ataacaagcg cgccattgct ttctatcaaa aaatgggttt tacttttgat   420
ggacaagaaa aaatacttga acttggaaag cctataaagg aaaaacggat ggtattctat   480
tctaaa                                                              486

<210>   2484
<211>   162
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903159 (7.E-88)

<400>   2484
Met Thr Val Ile Ile Lys Ser Met Glu Thr Pro Glu Glu Ile Glu Gly 
1               5                   10                  15      

Lys Ser Phe Val His Trp Gln Thr Trp Arg Glu Ala Tyr Asp Asp Leu 
            20                  25                  30          

Leu Pro Ala Glu Phe Gln Glu Thr Met Thr Leu Glu Arg Cys Arg Leu 
        35                  40                  45              

Phe Ser Gln Lys Tyr Pro Glu Asn Thr Leu Ile Ala Met Asp Gly Val 
    50                  55                  60                  

Lys Ile Val Gly Phe Ile Ser Tyr Gly Asn Cys Arg Asp Glu Thr Ile 
65                  70                  75                  80  

Gln Ala Gly Glu Ile Ile Ala Leu Tyr Val Leu Lys Asp Tyr Tyr Gly 
                85                  90                  95      

Lys Gly Ile Ala Gln Lys Leu Val Lys Ala Ala Leu Thr Asp Leu Asn 
            100                 105                 110         

His Phe Ser Glu Ile Phe Leu Trp Val Leu Lys Asp Asn Lys Arg Ala 
        115                 120                 125             

Ile Ala Phe Tyr Gln Lys Met Gly Phe Thr Phe Asp Gly Gln Glu Lys 
    130                 135                 140                 

Ile Leu Glu Leu Gly Lys Pro Ile Lys Glu Lys Arg Met Val Phe Tyr 
145                 150                 155                 160 

Ser Lys 
        

<210>   2485
<211>   561
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2485
atgatttatt taagaaagtt aaagaaagaa gatttgatgt ctttatggga aatggcttat   60
tcacagctta atccagtttg gaaacagtat gatgctccct attatgatga ttatcagtat   120
ttttcaaatt ttaaagaatt cgaactacaa aaatcagaat ccattttaag caactcaaat   180
cgccttggta tttttgttga tgataaacta gttgggactg tttcgcgtta ttgggtatgt   240
aaagaaacaa gatggatgga attgggaatt ggtatttatg ataaaaaatt ctggaacact   300
ggtattggga aagttgctat gttgcagtgg atagatagga cgtttcagga ttacttggag   360
ttggagcatc tgggtttgac aacttggtca ggaaatattg gtatgatgaa acttgctgaa   420
aaattaagaa tgaaaaaaga agctcatatt ccaaaagttc gttattatca aggtaaatat   480
tttgacagta ttaaatatgg tattttgaga gaagactggg agaaaataaa tgacggttat   540
tatcaaatca atggaaactc c                                             561

<210>   2486

<211>   187
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903160 (e-111)

<400>   2486
Met Ile Tyr Leu Arg Lys Leu Lys Lys Glu Asp Leu Met Ser Leu Trp 
1               5                   10                  15      

Glu Met Ala Tyr Ser Gln Leu Asn Pro Val Trp Lys Gln Tyr Asp Ala 
            20                  25                  30          

Pro Tyr Tyr Asp Asp Tyr Gln Tyr Phe Ser Asn Phe Lys Glu Phe Glu 
        35                  40                  45              

Leu Gln Lys Ser Glu Ser Ile Leu Ser Asn Ser Asn Arg Leu Gly Ile 
    50                  55                  60                  

Phe Val Asp Asp Lys Leu Val Gly Thr Val Ser Arg Tyr Trp Val Cys 
65                  70                  75                  80  

Lys Glu Thr Arg Trp Met Glu Leu Gly Ile Gly Ile Tyr Asp Lys Lys 
                85                  90                  95      

Phe Trp Asn Thr Gly Ile Gly Lys Val Ala Met Leu Gln Trp Ile Asp 
            100                 105                 110         

Arg Thr Phe Gln Asp Tyr Leu Glu Leu Glu His Leu Gly Leu Thr Thr 
        115                 120                 125             

Trp Ser Gly Asn Ile Gly Met Met Lys Leu Ala Glu Lys Leu Arg Met 
    130                 135                 140                 

Lys Lys Glu Ala His Ile Pro Lys Val Arg Tyr Tyr Gln Gly Lys Tyr 
145                 150                 155                 160 

Phe Asp Ser Ile Lys Tyr Gly Ile Leu Arg Glu Asp Trp Glu Lys Ile 
                165                 170                 175     

Asn Asp Gly Tyr Tyr Gln Ile Asn Gly Asn Ser 
            180                 185         

<210>   2487
<211>   1986
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2487
atgatcaatc acattacaga taatcaattt aaactagtat caaaatatca accatcagga   60
gatcaacccc aagctatcga gcagttggtg gataacattg aggggggaga aaaagctcag   120
attctgatgg gggcgactgg aacagggaag acctatacta tgagtcaggt catttctaaa   180
gtcaataaac caactctggt tattgcccac aataaaactc tggctggtca gctctatggg   240
gagtttaagg aatttttccc tgaaaatgca gttgagtatt tcgtatccta ctatgattat   300
taccagccag aggcctatgt cccttctagc gatacctata ttgagaagga tagttctgtc   360
aatgacgaga ttgacaagct tcgccactca gctacctcag cccttttgga gcgtaatgat   420
gttattgtcg tggcctcagt ctcttgtatc tatggtttgg gttcgcccaa ggaatacgct   480
gatagtgtcg ttagtctccg tcctggtcta gagatttctc gtgataaact cttgaatgac   540
ttggtcgata ttcagtttga acgtaatgat attgatttcc aacgcggaag atttcgcgtt   600
cgtggggatg tggtagagat tttcccagct tcccgagatg aacatgcctt tcgagtagaa   660
ttttttggag acgaaattga ccgtattcgt gaagttgagg ctctgacagg tcaggtgttg   720
ggagaagtgg atcatttagc gattttccca gcgacacact ttgtgaccaa tgacgaccac   780
atggaagttg ccattgcaaa gattcaggcc gagttggaag aacaattagc tgtctttgaa   840
aaggaaggta aactgcttga agcccagcgt ttgaaacagc ggacagagta tgatatcgaa   900
atgttgcgtg agatgggcta taccaatggg gttgaaaatt attctcgcca catggatgga   960
cggagcgaag gagagcctcc ttatacgctt ctcgacttct tcccagatga tttcttgatt   1020
atgattgacg agagtcatat gaccataggg caaatcaagg gcatgtacaa tggagaccgt   1080
tcgcgtaaag aaatgctggt taattatggt ttccgtttgc cgtctgcttt ggacaatcgt   1140
cctctccgtc gggaggagtt tgagagtcac gttcatcaga ttgtttacgt ttcagcgaca   1200
cctggtgact atgaaaatga acagaccgag acagtgattg agcaaatcat tcgtccaacg   1260
ggactcttgg atccagaggt ggaagtccgt ccgactatgg gacagattga tgacctcttg   1320
ggtgaaatca atgcccgcgt tgaaaaaaat gagcgtacct ttatcacaac tttgaccaag   1380
aaaatggcag aggatttgac cgactacttc aaggaaatgg gtatcaaggt caagtacatg   1440
cactcggata tcaagacctt ggaacggacg gagattatcc gtgacctgcg cttgggtgtc   1500
tttgatgtct tggtcggaat taacctgctc cgtgaaggaa ttgacgttcc tgaagtgagc   1560
ctcgtagcta ttctcgatgc tgacaaggaa ggtttccttc gcaacgaacg tggactcatc   1620
cagaccattg gacgtgctgc acgtaatagc gaaggtcatg ttatcatgta tgcggacacg   1680
gttacccagt ctatgcaacg tgctatcgat gaaactgccc gccgtcgcaa aatccagatg   1740
gcctataatg aagaacatgg tatcgttcca caaaccatca agaaagaaat ccgtgacttg   1800
attgctgtga ccaaggcagt tgctaaggaa gaagacaagg aagtcgatat caatagcctc   1860
aacaaacaag agcgcaaaga actagtcaaa aagcttgaga aacaaatgca agaagcagtt   1920
gaagtgcttg actttgaact agcagctcag attcgtgata tgatgctgga agtcaaggcc   1980
ttggat                                                              1986

<210>   2488
<211>   662
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   excinuclease ABC, subunit B (uvrB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903161 (0.E+01)

<400>   2488
Met Ile Asn His Ile Thr Asp Asn Gln Phe Lys Leu Val Ser Lys Tyr 
1               5                   10                  15      

Gln Pro Ser Gly Asp Gln Pro Gln Ala Ile Glu Gln Leu Val Asp Asn 
            20                  25                  30          

Ile Glu Gly Gly Glu Lys Ala Gln Ile Leu Met Gly Ala Thr Gly Thr 
        35                  40                  45              

Gly Lys Thr Tyr Thr Met Ser Gln Val Ile Ser Lys Val Asn Lys Pro 
    50                  55                  60                  

Thr Leu Val Ile Ala His Asn Lys Thr Leu Ala Gly Gln Leu Tyr Gly 
65                  70                  75                  80  

Glu Phe Lys Glu Phe Phe Pro Glu Asn Ala Val Glu Tyr Phe Val Ser 
                85                  90                  95      

Tyr Tyr Asp Tyr Tyr Gln Pro Glu Ala Tyr Val Pro Ser Ser Asp Thr 
            100                 105                 110         

Tyr Ile Glu Lys Asp Ser Ser Val Asn Asp Glu Ile Asp Lys Leu Arg 
        115                 120                 125             

His Ser Ala Thr Ser Ala Leu Leu Glu Arg Asn Asp Val Ile Val Val 
    130                 135                 140                 


Ala Ser Val Ser Cys Ile Tyr Gly Leu Gly Ser Pro Lys Glu Tyr Ala 
145                 150                 155                 160 

Asp Ser Val Val Ser Leu Arg Pro Gly Leu Glu Ile Ser Arg Asp Lys 
                165                 170                 175     

Leu Leu Asn Asp Leu Val Asp Ile Gln Phe Glu Arg Asn Asp Ile Asp 
            180                 185                 190         

Phe Gln Arg Gly Arg Phe Arg Val Arg Gly Asp Val Val Glu Ile Phe 
        195                 200                 205             

Pro Ala Ser Arg Asp Glu His Ala Phe Arg Val Glu Phe Phe Gly Asp 
    210                 215                 220                 

Glu Ile Asp Arg Ile Arg Glu Val Glu Ala Leu Thr Gly Gln Val Leu 
225                 230                 235                 240 

Gly Glu Val Asp His Leu Ala Ile Phe Pro Ala Thr His Phe Val Thr 
                245                 250                 255     

Asn Asp Asp His Met Glu Val Ala Ile Ala Lys Ile Gln Ala Glu Leu 
            260                 265                 270         

Glu Glu Gln Leu Ala Val Phe Glu Lys Glu Gly Lys Leu Leu Glu Ala 
        275                 280                 285             

Gln Arg Leu Lys Gln Arg Thr Glu Tyr Asp Ile Glu Met Leu Arg Glu 
    290                 295                 300                 

Met Gly Tyr Thr Asn Gly Val Glu Asn Tyr Ser Arg His Met Asp Gly 
305                 310                 315                 320 

Arg Ser Glu Gly Glu Pro Pro Tyr Thr Leu Leu Asp Phe Phe Pro Asp 
                325                 330                 335     

Asp Phe Leu Ile Met Ile Asp Glu Ser His Met Thr Ile Gly Gln Ile 
            340                 345                 350         

Lys Gly Met Tyr Asn Gly Asp Arg Ser Arg Lys Glu Met Leu Val Asn 
        355                 360                 365             

Tyr Gly Phe Arg Leu Pro Ser Ala Leu Asp Asn Arg Pro Leu Arg Arg 
    370                 375                 380                 

Glu Glu Phe Glu Ser His Val His Gln Ile Val Tyr Val Ser Ala Thr 
385                 390                 395                 400 

Pro Gly Asp Tyr Glu Asn Glu Gln Thr Glu Thr Val Ile Glu Gln Ile 
                405                 410                 415     

Ile Arg Pro Thr Gly Leu Leu Asp Pro Glu Val Glu Val Arg Pro Thr 
            420                 425                 430         

Met Gly Gln Ile Asp Asp Leu Leu Gly Glu Ile Asn Ala Arg Val Glu 
        435                 440                 445             

Lys Asn Glu Arg Thr Phe Ile Thr Thr Leu Thr Lys Lys Met Ala Glu 
    450                 455                 460                 

Asp Leu Thr Asp Tyr Phe Lys Glu Met Gly Ile Lys Val Lys Tyr Met 
465                 470                 475                 480 


His Ser Asp Ile Lys Thr Leu Glu Arg Thr Glu Ile Ile Arg Asp Leu 
                485                 490                 495     

Arg Leu Gly Val Phe Asp Val Leu Val Gly Ile Asn Leu Leu Arg Glu 
            500                 505                 510         

Gly Ile Asp Val Pro Glu Val Ser Leu Val Ala Ile Leu Asp Ala Asp 
        515                 520                 525             

Lys Glu Gly Phe Leu Arg Asn Glu Arg Gly Leu Ile Gln Thr Ile Gly 
    530                 535                 540                 

Arg Ala Ala Arg Asn Ser Glu Gly His Val Ile Met Tyr Ala Asp Thr 
545                 550                 555                 560 

Val Thr Gln Ser Met Gln Arg Ala Ile Asp Glu Thr Ala Arg Arg Arg 
                565                 570                 575     

Lys Ile Gln Met Ala Tyr Asn Glu Glu His Gly Ile Val Pro Gln Thr 
            580                 585                 590         

Ile Lys Lys Glu Ile Arg Asp Leu Ile Ala Val Thr Lys Ala Val Ala 
        595                 600                 605             

Lys Glu Glu Asp Lys Glu Val Asp Ile Asn Ser Leu Asn Lys Gln Glu 
    610                 615                 620                 

Arg Lys Glu Leu Val Lys Lys Leu Glu Lys Gln Met Gln Glu Ala Val 
625                 630                 635                 640 

Glu Val Leu Asp Phe Glu Leu Ala Ala Gln Ile Arg Asp Met Met Leu 
                645                 650                 655     

Glu Val Lys Ala Leu Asp 
            660         

<210>   2489
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2489
atgacctttt taccacaagg caatcaagat tggctatcag gtggttcttt tggcatagaa   60
ggttccatta tgacaagtct ggtattacta ctgctgattg tctatcttgc taataaatta   120
aagaaagaaa atgaaaggat g                                             141

<210>   2490
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2490
Met Thr Phe Leu Pro Gln Gly Asn Gln Asp Trp Leu Ser Gly Gly Ser 
1               5                   10                  15      

Phe Gly Ile Glu Gly Ser Ile Met Thr Ser Leu Val Leu Leu Leu Leu 
            20                  25                  30          

Ile Val Tyr Leu Ala Asn Lys Leu Lys Lys Glu Asn Glu Arg Met 
        35                  40                  45          

<210>   2491
<211>   807
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2491
atgaagaaca aaagaatatt taaagacttc caagcttcaa aaatgagttt aaacatttac   60
acaagcccct tgttagcctt tgtttttgtc ttcataggag agtttgtggc ttttactttg   120
tatggtattg gcttgttagc tctcatcgga cttgctagaa attttggaga ggctggtcaa   180
aatcttgcaa gctacttgca gaccttgcat cagagcttga cggataaaac aagtgacttt   240
cgtttaattt taggattact ggcctttggt tttattctta acactgtgtt cagatggaca   300
agaaaagttg agaaaagacc tattcgaacc ttgggatttt atagagagaa tttcctcagc   360
aatcttctga aaggatttag tctaggcctg gcactttttc ttctgacctt gttaggttta   420
gtggtcttag gtcaatatcg tttggaatcc attcacttga atccttattc tcttgccttt   480
gtcgtcttta ctatcccatt ttggatttta caggggacag cagaagaagt ggtggcccgt   540
gcttggctac ttcctcaatt ggcctcaaga accaatctaa aactagctat tcttatatct   600
agcctgttct ttaccctgct tcatatgggc aattctggtc tcacccctct atctctagta   660
aatctctttt tattcggagt tgccatggct ctttaccttc tcaaaactga tacagtttgg   720
ggtgttgcag gtattcatgg tgcttggaat tttgctcagg gtaatctctt tgggatttta   780
gttagtggtc aaccgtcaga acgtctc                                       807

<210>   2492
<211>   269
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, FRAMESHIFT
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903162 (e-179)

<400>   2492
Met Lys Asn Lys Arg Ile Phe Lys Asp Phe Gln Ala Ser Lys Met Ser 
1               5                   10                  15      

Leu Asn Ile Tyr Thr Ser Pro Leu Leu Ala Phe Val Phe Val Phe Ile 
            20                  25                  30          

Gly Glu Phe Val Ala Phe Thr Leu Tyr Gly Ile Gly Leu Leu Ala Leu 
        35                  40                  45              

Ile Gly Leu Ala Arg Asn Phe Gly Glu Ala Gly Gln Asn Leu Ala Ser 
    50                  55                  60                  

Tyr Leu Gln Thr Leu His Gln Ser Leu Thr Asp Lys Thr Ser Asp Phe 
65                  70                  75                  80  

Arg Leu Ile Leu Gly Leu Leu Ala Phe Gly Phe Ile Leu Asn Thr Val 
                85                  90                  95      

Phe Arg Trp Thr Arg Lys Val Glu Lys Arg Pro Ile Arg Thr Leu Gly 
            100                 105                 110         

Phe Tyr Arg Glu Asn Phe Leu Ser Asn Leu Leu Lys Gly Phe Ser Leu 
        115                 120                 125             

Gly Leu Ala Leu Phe Leu Leu Thr Leu Leu Gly Leu Val Val Leu Gly 
    130                 135                 140                 

Gln Tyr Arg Leu Glu Ser Ile His Leu Asn Pro Tyr Ser Leu Ala Phe 
145                 150                 155                 160 

Val Val Phe Thr Ile Pro Phe Trp Ile Leu Gln Gly Thr Ala Glu Glu 
                165                 170                 175     

Val Val Ala Arg Ala Trp Leu Leu Pro Gln Leu Ala Ser Arg Thr Asn 
            180                 185                 190         

Leu Lys Leu Ala Ile Leu Ile Ser Ser Leu Phe Phe Thr Leu Leu His 
        195                 200                 205             

Met Gly Asn Ser Gly Leu Thr Pro Leu Ser Leu Val Asn Leu Phe Leu 
    210                 215                 220                 

Phe Gly Val Ala Met Ala Leu Tyr Leu Leu Lys Thr Asp Thr Val Trp 
225                 230                 235                 240 


Gly Val Ala Gly Ile His Gly Ala Trp Asn Phe Ala Gln Gly Asn Leu 
                245                 250                 255     

Phe Gly Ile Leu Val Ser Gly Gln Pro Ser Glu Arg Leu 
            260                 265                 

<210>   2493
<211>   2163
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2493
atgaagaaaa aatttctagc atttttgcta attttattcc caattttctc attaggtatt   60
gccaaagcag aaacgattaa gattgtttct gataccgcct atgcaccttt tgagtttaaa   120
gattcagatc aaacttataa aggaattgat gttgacatta ttaacaaagt cgctgagatt   180
aaaggctgga acattcagat gtcctatcct ggatttgacg cagcagtcaa tgcggttcaa   240
gctgggcaag ccgacgctat catggcaggg atgacaaaga ctaaagaacg tgaaaaagtc   300
ttcaccatgt ctgatactta ctatgataca aaagttgtca ttgctactac aaagtcacac   360
aaaattagca agtacgacca attaactggc aaaaccgttg gtgttaaaaa cggaactgcc   420
gctcaacgtt tccttgaaac aatcaaagat aaatacggct ttactattaa aacatttgac   480
actggtgatt taatgaacaa cagcttgagt gctggtgcca tcgatgccat gatggatgac   540
aaacctgtta tcgaatatgc cattaaccaa ggtcaagacc tccatattga aatggatggt   600
gaagctgtag gaagttttgc tttcggtgtg aaaaaaggaa gtaaatacga gcacctggtt   660
actgaattta accaagcctt gtctgaaatg aaaaaagatg gtagtcttga taaaattatc   720
aagaaatgga ctgcttcatc atcttcagca gtgccaacta caactactct cgcaggatta   780
aaagctattc ctgttaaggc taaatatatc attgccagcg attcttcttt tgcccctttt   840
gttttccaaa attcaagcaa ccaatacact ggtattgata tggaattgat taaggcaatc   900
gctaaagacc aaggttttga aattgaaatc accaaccctg gttttgatgc tgctatcagt   960
gctgtccaag ctggtcaagc cgatggtatc atcgctggta tgtctgtcac agatgctcgt   1020
aaggcaactt ttgacttctc agaatcatac tacactgcta ataccattct tggtgtcaaa   1080
gaatcaagca atattgcttc ttatgaagat ctaaaaggaa agacagtcgg tgttaaaaac   1140
ggaactgctt ctcaaacctt cctaacagaa aatcaaagca aatacggcta caaaatcaaa   1200
acctttgctg atggttcttc aatgtatgac agtttaaaca ctggtgccat tgatgccgtt   1260
atggatgatg aacctgttct caaatattct atcagccaag gtcaaaaatt gaaaactcca   1320
atctctggaa ctccaatcgg tgaaacagcc tttgccgtta aaaaaggagc aaatccagaa   1380
ctgattgaaa tgttcaacaa cggacttgca aaccttaaag caaacggtga attccaaaag   1440
attcttgaca aatacctagc tagcgaatct tcaactgctt caacaagtac tgttgacgaa   1500
acaacgctct ggggcttgct tcaaaacaac tacaaacaac tccttagcgg tcttggtatc   1560
actcttgctc tagctcttat ctcatttgct attgccattg tcatcggaat tatcttcggt   1620
atgtttagcg ttagcccata caaatctctt cgcgtcatct ctgagatttt cgttgacgtt   1680
attcgtggta ttccattgat gattcttgca gccttcatct tctggggaat tccaaacttc   1740
atcgagtcta tcacaggcca acaaagccca attaacgact ttgtagctgg aaccattgcc   1800
ctctcactca atgcggctgc ttatatcgct gaaatcgttc gtggtggtat tcaggccgtt   1860
ccagttggcc aaatggaagc cagccgaagc ttgggtatct cttatggaaa aaccatgcgt   1920
aagattatct tgccacaagc aactaaattg atgttgccaa actttgtcaa ccaattcgtt   1980
atcgctctta aagatacaac tatcgtatct gctatcggtt tggttgaact cttccaaact   2040
ggtaagatta tcattgctcg taactaccaa agtttcaaga tgtatgcaat ccttgctatc   2100
ttctatcttg taattatcac acttttgact agactagcga aacgcttaga aaagaggatt   2160
cgt                                                                 2163

<210>   2494
<211>   721
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, amino acid-binding protein/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903163 (0.E+01)

<400>   2494
Met Lys Lys Lys Phe Leu Ala Phe Leu Leu Ile Leu Phe Pro Ile Phe 
1               5                   10                  15      

Ser Leu Gly Ile Ala Lys Ala Glu Thr Ile Lys Ile Val Ser Asp Thr 
            20                  25                  30          

Ala Tyr Ala Pro Phe Glu Phe Lys Asp Ser Asp Gln Thr Tyr Lys Gly 
        35                  40                  45              

Ile Asp Val Asp Ile Ile Asn Lys Val Ala Glu Ile Lys Gly Trp Asn 
    50                  55                  60                  

Ile Gln Met Ser Tyr Pro Gly Phe Asp Ala Ala Val Asn Ala Val Gln 
65                  70                  75                  80  

Ala Gly Gln Ala Asp Ala Ile Met Ala Gly Met Thr Lys Thr Lys Glu 
                85                  90                  95      

Arg Glu Lys Val Phe Thr Met Ser Asp Thr Tyr Tyr Asp Thr Lys Val 
            100                 105                 110         

Val Ile Ala Thr Thr Lys Ser His Lys Ile Ser Lys Tyr Asp Gln Leu 
        115                 120                 125             

Thr Gly Lys Thr Val Gly Val Lys Asn Gly Thr Ala Ala Gln Arg Phe 
    130                 135                 140                 

Leu Glu Thr Ile Lys Asp Lys Tyr Gly Phe Thr Ile Lys Thr Phe Asp 
145                 150                 155                 160 

Thr Gly Asp Leu Met Asn Asn Ser Leu Ser Ala Gly Ala Ile Asp Ala 
                165                 170                 175     

Met Met Asp Asp Lys Pro Val Ile Glu Tyr Ala Ile Asn Gln Gly Gln 
            180                 185                 190         

Asp Leu His Ile Glu Met Asp Gly Glu Ala Val Gly Ser Phe Ala Phe 
        195                 200                 205             

Gly Val Lys Lys Gly Ser Lys Tyr Glu His Leu Val Thr Glu Phe Asn 
    210                 215                 220                 

Gln Ala Leu Ser Glu Met Lys Lys Asp Gly Ser Leu Asp Lys Ile Ile 
225                 230                 235                 240 

Lys Lys Trp Thr Ala Ser Ser Ser Ser Ala Val Pro Thr Thr Thr Thr 
                245                 250                 255     

Leu Ala Gly Leu Lys Ala Ile Pro Val Lys Ala Lys Tyr Ile Ile Ala 
            260                 265                 270         

Ser Asp Ser Ser Phe Ala Pro Phe Val Phe Gln Asn Ser Ser Asn Gln 
        275                 280                 285             

Tyr Thr Gly Ile Asp Met Glu Leu Ile Lys Ala Ile Ala Lys Asp Gln 
    290                 295                 300                 

Gly Phe Glu Ile Glu Ile Thr Asn Pro Gly Phe Asp Ala Ala Ile Ser 
305                 310                 315                 320 

Ala Val Gln Ala Gly Gln Ala Asp Gly Ile Ile Ala Gly Met Ser Val 
                325                 330                 335     

Thr Asp Ala Arg Lys Ala Thr Phe Asp Phe Ser Glu Ser Tyr Tyr Thr 
            340                 345                 350         

Ala Asn Thr Ile Leu Gly Val Lys Glu Ser Ser Asn Ile Ala Ser Tyr 
        355                 360                 365             

Glu Asp Leu Lys Gly Lys Thr Val Gly Val Lys Asn Gly Thr Ala Ser 
    370                 375                 380                 

Gln Thr Phe Leu Thr Glu Asn Gln Ser Lys Tyr Gly Tyr Lys Ile Lys 
385                 390                 395                 400 

Thr Phe Ala Asp Gly Ser Ser Met Tyr Asp Ser Leu Asn Thr Gly Ala 

                405                 410                 415     

Ile Asp Ala Val Met Asp Asp Glu Pro Val Leu Lys Tyr Ser Ile Ser 
            420                 425                 430         

Gln Gly Gln Lys Leu Lys Thr Pro Ile Ser Gly Thr Pro Ile Gly Glu 
        435                 440                 445             

Thr Ala Phe Ala Val Lys Lys Gly Ala Asn Pro Glu Leu Ile Glu Met 
    450                 455                 460                 

Phe Asn Asn Gly Leu Ala Asn Leu Lys Ala Asn Gly Glu Phe Gln Lys 
465                 470                 475                 480 

Ile Leu Asp Lys Tyr Leu Ala Ser Glu Ser Ser Thr Ala Ser Thr Ser 
                485                 490                 495     

Thr Val Asp Glu Thr Thr Leu Trp Gly Leu Leu Gln Asn Asn Tyr Lys 
            500                 505                 510         

Gln Leu Leu Ser Gly Leu Gly Ile Thr Leu Ala Leu Ala Leu Ile Ser 
        515                 520                 525             

Phe Ala Ile Ala Ile Val Ile Gly Ile Ile Phe Gly Met Phe Ser Val 
    530                 535                 540                 

Ser Pro Tyr Lys Ser Leu Arg Val Ile Ser Glu Ile Phe Val Asp Val 
545                 550                 555                 560 

Ile Arg Gly Ile Pro Leu Met Ile Leu Ala Ala Phe Ile Phe Trp Gly 
                565                 570                 575     

Ile Pro Asn Phe Ile Glu Ser Ile Thr Gly Gln Gln Ser Pro Ile Asn 
            580                 585                 590         

Asp Phe Val Ala Gly Thr Ile Ala Leu Ser Leu Asn Ala Ala Ala Tyr 
        595                 600                 605             

Ile Ala Glu Ile Val Arg Gly Gly Ile Gln Ala Val Pro Val Gly Gln 
    610                 615                 620                 

Met Glu Ala Ser Arg Ser Leu Gly Ile Ser Tyr Gly Lys Thr Met Arg 
625                 630                 635                 640 

Lys Ile Ile Leu Pro Gln Ala Thr Lys Leu Met Leu Pro Asn Phe Val 
                645                 650                 655     

Asn Gln Phe Val Ile Ala Leu Lys Asp Thr Thr Ile Val Ser Ala Ile 
            660                 665                 670         

Gly Leu Val Glu Leu Phe Gln Thr Gly Lys Ile Ile Ile Ala Arg Asn 
        675                 680                 685             

Tyr Gln Ser Phe Lys Met Tyr Ala Ile Leu Ala Ile Phe Tyr Leu Val 
    690                 695                 700                 

Ile Ile Thr Leu Leu Thr Arg Leu Ala Lys Arg Leu Glu Lys Arg Ile 
705                 710                 715                 720 

Arg 
    

<210>   2495
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2495
atggcaaaat taaaaattga tgtaaatgat ttacacaagc actatggaaa aaatgaagtc   60
ctaaaaggaa ttacgactaa gttctatgaa ggagatgttg tttgtatcat cggtccttca   120
ggttctggta agtcaacttt cctccgtagc ctcaatcttt tagaagaagt cactagcggt   180
cacatcactg tgaacggcta tgatttaact gaaaaaacaa ccaatgttga ccacgtccgt   240
gaaaatatcg gcatggtatt ccaacacttc aacctcttcc ctcatatgtc tgtattggac   300
aacatcacct ttgctcctat tgagcacaag ttgatgacta aggaagaagc tgaggaattg   360
ggaatggagt tgcttgaaaa ggttggacta gcagataaag ctaatgccaa tccagatagc   420
ctatcaggtg gtcaaaaaca acgtgtggcc atcgctcgtg gcctagcaat gaatccagac   480
atcatgctct tcgatgaacc aacttctgcc cttgaccctg agatggttgg agacgtactt   540
aacgttatga aggaattggc tgagcaaggc atgaccatga ttatcgtaac ccatgagatg   600
ggatttgctc gtcaggttgc caaccgcgtt atctttactg cagatggcga gttccttgaa   660
gacggaacac ctgaccaaat ctttgataac ccacaacacc ctcgtctgaa agagttctta   720
gataaggtct taaacgtc                                                 738

<210>   2496
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903164 (e-140)

<400>   2496
Met Ala Lys Leu Lys Ile Asp Val Asn Asp Leu His Lys His Tyr Gly 
1               5                   10                  15      

Lys Asn Glu Val Leu Lys Gly Ile Thr Thr Lys Phe Tyr Glu Gly Asp 
            20                  25                  30          

Val Val Cys Ile Ile Gly Pro Ser Gly Ser Gly Lys Ser Thr Phe Leu 
        35                  40                  45              

Arg Ser Leu Asn Leu Leu Glu Glu Val Thr Ser Gly His Ile Thr Val 
    50                  55                  60                  

Asn Gly Tyr Asp Leu Thr Glu Lys Thr Thr Asn Val Asp His Val Arg 
65                  70                  75                  80  

Glu Asn Ile Gly Met Val Phe Gln His Phe Asn Leu Phe Pro His Met 
                85                  90                  95      

Ser Val Leu Asp Asn Ile Thr Phe Ala Pro Ile Glu His Lys Leu Met 
            100                 105                 110         

Thr Lys Glu Glu Ala Glu Glu Leu Gly Met Glu Leu Leu Glu Lys Val 
        115                 120                 125             

Gly Leu Ala Asp Lys Ala Asn Ala Asn Pro Asp Ser Leu Ser Gly Gly 
    130                 135                 140                 

Gln Lys Gln Arg Val Ala Ile Ala Arg Gly Leu Ala Met Asn Pro Asp 
145                 150                 155                 160 

Ile Met Leu Phe Asp Glu Pro Thr Ser Ala Leu Asp Pro Glu Met Val 
                165                 170                 175     

Gly Asp Val Leu Asn Val Met Lys Glu Leu Ala Glu Gln Gly Met Thr 
            180                 185                 190         

Met Ile Ile Val Thr His Glu Met Gly Phe Ala Arg Gln Val Ala Asn 
        195                 200                 205             

Arg Val Ile Phe Thr Ala Asp Gly Glu Phe Leu Glu Asp Gly Thr Pro 

    210                 215                 220                 

Asp Gln Ile Phe Asp Asn Pro Gln His Pro Arg Leu Lys Glu Phe Leu 
225                 230                 235                 240 

Asp Lys Val Leu Asn Val 
                245     


<210>   2497
<211>   1485
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2497
atgtcatcta aggttattgt tacaattttc ggtgcgagtg gagacctggc taaacgcaag   60
ctctaccctt ccctttttag actatatcaa tccggcaatc tttccaagca ctttgccgtt   120
attggaactg cccgtagacc ttggagtaag gaatattttg aatctgtagt tgtcgagtcc   180
atccttgatt tggcagatag taccgagcaa gcccaagaat ttgctagcca cttctactat   240
caaagccatg atgtcaatga ttcggaacat tatattgctt tgcgtcaatt acaagctgag   300
cttaatgaaa aataccaagc tgaacacaat aagctcttct tcttgtctat ggcacctcag   360
ttctttggaa ccattgccaa acacctcaaa tctgaaaaca ttgtcgatgg caaaggtttt   420
gagcgcttga tcgttgaaaa accatttggt acagattacg caactgcaag caagttgaat   480
gacgaactcc tagcaacatt tgacgaagaa caaattttcc gtatcgacca ttatcttggt   540
aaggaaatga tccaaagcat ctttgcagtt cgctttgcaa acttgatttt tgaaaacgtt   600
tggaacaagg attttatcga caatgttcaa attacctttg cggagcgctt gggtgtagaa   660
gaacgtggtg gctactatga ccaatccggt gccctccgtg acatggtcca aaaccacact   720
ctacaacttc tttcgctcct cgccatggac aaaccagcaa gcttcacaaa agacgagatt   780
cgtgctgaaa agattaaggt ctttaaaaac ctctatcatc caactgatga agaactcaaa   840
gaacacttta tccgtgggca ataccgctct ggtaagattg atggcatgaa atacatctct   900
tatcgtagcg agccaaatgt gaatccagaa tcaacaactg aaacctttac atctggtgcc   960
ttctttgtag acagcgatcg attccgtggt gttcctttct ttttccgtac aggtaaacga   1020
ctgactgaaa aaggaactca tgtcaacatc gtctttaaac aaatggattc tatctttgga   1080
gaaccacttg ctccaaatat tttgaccatc tatattcaac caacagaagg cttctctctt   1140
agcctaaatg ggaagcaagt aggagaagaa tttaacttgg ctcctaactc acttgattac   1200
cgtacagatg cgactgcaac tggtgcttct ccagaaccat acgaaaaatt gatttatgat   1260
gtcctaaata acaactcaac taactttagc cactgggatg aagtttgtgc gtcatggaag   1320
ttgattgacc gtattgaaaa gctctgggct gaaaatggtg ccccacttca tgactataaa   1380
gctggaagca tgggacctca agccagcttt gacctacttg aaaaattcgg tgccaaatgg   1440
acttggcaac cagatatcac ctatcgtcaa gatggtcgct tagaa                   1485

<210>   2498
<211>   495
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucose-6-phosphate 1-dehydrogenase (zwf)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903165 (0.E+01)

<400>   2498
Met Ser Ser Lys Val Ile Val Thr Ile Phe Gly Ala Ser Gly Asp Leu 
1               5                   10                  15      

Ala Lys Arg Lys Leu Tyr Pro Ser Leu Phe Arg Leu Tyr Gln Ser Gly 
            20                  25                  30          

Asn Leu Ser Lys His Phe Ala Val Ile Gly Thr Ala Arg Arg Pro Trp 
        35                  40                  45              

Ser Lys Glu Tyr Phe Glu Ser Val Val Val Glu Ser Ile Leu Asp Leu 
    50                  55                  60                  

Ala Asp Ser Thr Glu Gln Ala Gln Glu Phe Ala Ser His Phe Tyr Tyr 
65                  70                  75                  80  

Gln Ser His Asp Val Asn Asp Ser Glu His Tyr Ile Ala Leu Arg Gln 
                85                  90                  95      

Leu Gln Ala Glu Leu Asn Glu Lys Tyr Gln Ala Glu His Asn Lys Leu 
            100                 105                 110         

Phe Phe Leu Ser Met Ala Pro Gln Phe Phe Gly Thr Ile Ala Lys His 
        115                 120                 125             

Leu Lys Ser Glu Asn Ile Val Asp Gly Lys Gly Phe Glu Arg Leu Ile 
    130                 135                 140                 

Val Glu Lys Pro Phe Gly Thr Asp Tyr Ala Thr Ala Ser Lys Leu Asn 
145                 150                 155                 160 

Asp Glu Leu Leu Ala Thr Phe Asp Glu Glu Gln Ile Phe Arg Ile Asp 
                165                 170                 175     

His Tyr Leu Gly Lys Glu Met Ile Gln Ser Ile Phe Ala Val Arg Phe 
            180                 185                 190         

Ala Asn Leu Ile Phe Glu Asn Val Trp Asn Lys Asp Phe Ile Asp Asn 
        195                 200                 205             

Val Gln Ile Thr Phe Ala Glu Arg Leu Gly Val Glu Glu Arg Gly Gly 
    210                 215                 220                 

Tyr Tyr Asp Gln Ser Gly Ala Leu Arg Asp Met Val Gln Asn His Thr 
225                 230                 235                 240 

Leu Gln Leu Leu Ser Leu Leu Ala Met Asp Lys Pro Ala Ser Phe Thr 
                245                 250                 255     

Lys Asp Glu Ile Arg Ala Glu Lys Ile Lys Val Phe Lys Asn Leu Tyr 
            260                 265                 270         


His Pro Thr Asp Glu Glu Leu Lys Glu His Phe Ile Arg Gly Gln Tyr 
        275                 280                 285             

Arg Ser Gly Lys Ile Asp Gly Met Lys Tyr Ile Ser Tyr Arg Ser Glu 
    290                 295                 300                 

Pro Asn Val Asn Pro Glu Ser Thr Thr Glu Thr Phe Thr Ser Gly Ala 
305                 310                 315                 320 

Phe Phe Val Asp Ser Asp Arg Phe Arg Gly Val Pro Phe Phe Phe Arg 
                325                 330                 335     

Thr Gly Lys Arg Leu Thr Glu Lys Gly Thr His Val Asn Ile Val Phe 
            340                 345                 350         

Lys Gln Met Asp Ser Ile Phe Gly Glu Pro Leu Ala Pro Asn Ile Leu 
        355                 360                 365             

Thr Ile Tyr Ile Gln Pro Thr Glu Gly Phe Ser Leu Ser Leu Asn Gly 
    370                 375                 380                 

Lys Gln Val Gly Glu Glu Phe Asn Leu Ala Pro Asn Ser Leu Asp Tyr 
385                 390                 395                 400 

Arg Thr Asp Ala Thr Ala Thr Gly Ala Ser Pro Glu Pro Tyr Glu Lys 
                405                 410                 415     

Leu Ile Tyr Asp Val Leu Asn Asn Asn Ser Thr Asn Phe Ser His Trp 
            420                 425                 430         

Asp Glu Val Cys Ala Ser Trp Lys Leu Ile Asp Arg Ile Glu Lys Leu 
        435                 440                 445             

Trp Ala Glu Asn Gly Ala Pro Leu His Asp Tyr Lys Ala Gly Ser Met 
    450                 455                 460                 

Gly Pro Gln Ala Ser Phe Asp Leu Leu Glu Lys Phe Gly Ala Lys Trp 
465                 470                 475                 480 

Thr Trp Gln Pro Asp Ile Thr Tyr Arg Gln Asp Gly Arg Leu Glu 
                485                 490                 495 

<210>   2499
<211>   1287
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2499
atgggattgt ttgaccgtct attcggaaaa aaagaagaac ctaaaatcga agaagttgta   60
aaagaagctc tggaaaatct tgatttgtct gaagatgttg atcctacctt cacagaagtt   120
gaggaagttt ctcaggaaga agcagaggtt gaaattgttg aacaagctgt gttccaagaa   180
gaggaaatcc aagacacagt tgaagaaagt caggattcag agccagctgt aggggtttct   240
caagaagaaa tagaagaatt accaaactca gaagaattac cagaggaaga gaagcttgag   300
cacgaaggaa ctgtagaaga aaataattct gaagtgcttg aaccagaagc tcctcaaaca   360
gaagaaactg ttcaggaaaa atatgaccgc agtcttaaga aaactcgcac aggtttcggt   420
gcccgcttga atgccttctt tgctaacttc cgctctgttg acgaagaatt tttcgaggaa   480
ctggaagaac tgctgattat gagtgatgtt ggtgtccaag tcgcttctaa cttaacggag   540
gaactacgtt acgaagccaa gcttgaaaat gccaagaaac ctgatgtact tcgtcgtgtc   600
atcattgaga aattggttga gctttatgaa aaggatggta gctacgatga aagcatccac   660
ttccaagata acttgacagt tatgctcttt gttggtgtga atggtgttgg gaaaacaact   720
tctatcggaa aactagccca ccgctacaaa caagctggta agaaggtcat gctggttgca   780
gcagatacct tccgtgcggg tgcagtagct cagctagctg aatggggccg acgagtagat   840
gttccagtag taactggacc tgaaaaagct gatccagcca gcgtggtctt tgatggtatg   900
gaacgtgccg tgactgaagg tatcgatatt ctcatgattg atactgctgg tcgtctgcaa   960
aataaggata accttatggc tgagttggaa aagattggtc gtattatcaa acgtgttgtg   1020
ccagaagcac cacatgaaac cttcttggca cttgatgcat caacaggtca aaatgcccta   1080
gtacaggcca aagaattttc gaaaatcaca cctttaacgg gaattgtttt gactaagatt   1140
gatggaactg ctcgaggagg tgtggttcta gccattcgtg aagaactcaa tattcctgta   1200
aaattgattg gttttggtga aaaaatcgat gatattggag agtttaactc agaaaacttt   1260
atgaaaggtc tcttggaagg tttaatc                                       1287

<210>   2500
<211>   429
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   signal recognition particle-docking protein FtsY (ftsY)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903166 (0.E+01)

<400>   2500
Met Gly Leu Phe Asp Arg Leu Phe Gly Lys Lys Glu Glu Pro Lys Ile 
1               5                   10                  15      

Glu Glu Val Val Lys Glu Ala Leu Glu Asn Leu Asp Leu Ser Glu Asp 
            20                  25                  30          

Val Asp Pro Thr Phe Thr Glu Val Glu Glu Val Ser Gln Glu Glu Ala 
        35                  40                  45              

Glu Val Glu Ile Val Glu Gln Ala Val Phe Gln Glu Glu Glu Ile Gln 
    50                  55                  60                  

Asp Thr Val Glu Glu Ser Gln Asp Ser Glu Pro Ala Val Gly Val Ser 
65                  70                  75                  80  

Gln Glu Glu Ile Glu Glu Leu Pro Asn Ser Glu Glu Leu Pro Glu Glu 
                85                  90                  95      

Glu Lys Leu Glu His Glu Gly Thr Val Glu Glu Asn Asn Ser Glu Val 

            100                 105                 110         

Leu Glu Pro Glu Ala Pro Gln Thr Glu Glu Thr Val Gln Glu Lys Tyr 
        115                 120                 125             

Asp Arg Ser Leu Lys Lys Thr Arg Thr Gly Phe Gly Ala Arg Leu Asn 
    130                 135                 140                 

Ala Phe Phe Ala Asn Phe Arg Ser Val Asp Glu Glu Phe Phe Glu Glu 
145                 150                 155                 160 

Leu Glu Glu Leu Leu Ile Met Ser Asp Val Gly Val Gln Val Ala Ser 
                165                 170                 175     

Asn Leu Thr Glu Glu Leu Arg Tyr Glu Ala Lys Leu Glu Asn Ala Lys 
            180                 185                 190         

Lys Pro Asp Val Leu Arg Arg Val Ile Ile Glu Lys Leu Val Glu Leu 
        195                 200                 205             

Tyr Glu Lys Asp Gly Ser Tyr Asp Glu Ser Ile His Phe Gln Asp Asn 
    210                 215                 220                 

Leu Thr Val Met Leu Phe Val Gly Val Asn Gly Val Gly Lys Thr Thr 
225                 230                 235                 240 

Ser Ile Gly Lys Leu Ala His Arg Tyr Lys Gln Ala Gly Lys Lys Val 
                245                 250                 255     

Met Leu Val Ala Ala Asp Thr Phe Arg Ala Gly Ala Val Ala Gln Leu 
            260                 265                 270         

Ala Glu Trp Gly Arg Arg Val Asp Val Pro Val Val Thr Gly Pro Glu 
        275                 280                 285             

Lys Ala Asp Pro Ala Ser Val Val Phe Asp Gly Met Glu Arg Ala Val 
    290                 295                 300                 

Thr Glu Gly Ile Asp Ile Leu Met Ile Asp Thr Ala Gly Arg Leu Gln 
305                 310                 315                 320 

Asn Lys Asp Asn Leu Met Ala Glu Leu Glu Lys Ile Gly Arg Ile Ile 
                325                 330                 335     

Lys Arg Val Val Pro Glu Ala Pro His Glu Thr Phe Leu Ala Leu Asp 
            340                 345                 350         

Ala Ser Thr Gly Gln Asn Ala Leu Val Gln Ala Lys Glu Phe Ser Lys 
        355                 360                 365             

Ile Thr Pro Leu Thr Gly Ile Val Leu Thr Lys Ile Asp Gly Thr Ala 
    370                 375                 380                 

Arg Gly Gly Val Val Leu Ala Ile Arg Glu Glu Leu Asn Ile Pro Val 
385                 390                 395                 400 

Lys Leu Ile Gly Phe Gly Glu Lys Ile Asp Asp Ile Gly Glu Phe Asn 
                405                 410                 415     

Ser Glu Asn Phe Met Lys Gly Leu Leu Glu Gly Leu Ile 
            420                 425                 

<210>   2501
<211>   816
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2501
atggcagata taaaattgat tgcattggac ttggacggga ccttgctgac tactgataaa   60
aggctgacgg atcgtaccaa ggaaaccttg caagctgcgc gtgatcgtgg tatcaaggtc   120
gtattgacaa ctggtcgtcc cttaaaagcc atggatttct ttctccatga gttagggact   180
gacggtcagg aagatgagta taccattact tttaatggtg gattagttca gaaaaataca   240
ggagaaatcc ttgataaaac agtcttttca tatgatgatg tggcacgttt gtatgaagaa   300
acagagaaat tatcactgcc tcttgatgcc atctcagaag gaacagttta tcaaatccaa   360
tcggaccaag aaagtcttta tgccaaattc aatccagctt tgacctttgt tccagtggac   420
tttgaagact tatctagtca aatgacctac aacaaatgcg tgactgcctt tgctcaagaa   480
cccttggatg cagccattca gaagatttct ccagaattgt ttgaccaata tgaaatcttt   540
aaatcacgtg aaatgttgct agaatggtca ccaaagaatg ttcataaagc aacaggtttg   600
gcaaaactaa tcagccatct tggaatcgac caaagtcaag tgatggcttg tggtgacgag   660
gccaatgacc tctctatgat tgaatgggca ggtcttggtg ttgctatgca aaacgctgtt   720
cctgaagtaa aggcagccgc aaatgtagtg acgccgatga ccaacgatga ggaagctgtc   780
gcctgggcta tcgaagaata tgtgctaaag gagaac                             816

<210>   2502
<211>   272
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Cof family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903167 (e-154)

<400>   2502
Met Ala Asp Ile Lys Leu Ile Ala Leu Asp Leu Asp Gly Thr Leu Leu 
1               5                   10                  15      


Thr Thr Asp Lys Arg Leu Thr Asp Arg Thr Lys Glu Thr Leu Gln Ala 
            20                  25                  30          

Ala Arg Asp Arg Gly Ile Lys Val Val Leu Thr Thr Gly Arg Pro Leu 
        35                  40                  45              

Lys Ala Met Asp Phe Phe Leu His Glu Leu Gly Thr Asp Gly Gln Glu 
    50                  55                  60                  

Asp Glu Tyr Thr Ile Thr Phe Asn Gly Gly Leu Val Gln Lys Asn Thr 
65                  70                  75                  80  

Gly Glu Ile Leu Asp Lys Thr Val Phe Ser Tyr Asp Asp Val Ala Arg 
                85                  90                  95      

Leu Tyr Glu Glu Thr Glu Lys Leu Ser Leu Pro Leu Asp Ala Ile Ser 
            100                 105                 110         

Glu Gly Thr Val Tyr Gln Ile Gln Ser Asp Gln Glu Ser Leu Tyr Ala 
        115                 120                 125             

Lys Phe Asn Pro Ala Leu Thr Phe Val Pro Val Asp Phe Glu Asp Leu 
    130                 135                 140                 

Ser Ser Gln Met Thr Tyr Asn Lys Cys Val Thr Ala Phe Ala Gln Glu 
145                 150                 155                 160 

Pro Leu Asp Ala Ala Ile Gln Lys Ile Ser Pro Glu Leu Phe Asp Gln 
                165                 170                 175     

Tyr Glu Ile Phe Lys Ser Arg Glu Met Leu Leu Glu Trp Ser Pro Lys 
            180                 185                 190         

Asn Val His Lys Ala Thr Gly Leu Ala Lys Leu Ile Ser His Leu Gly 
        195                 200                 205             

Ile Asp Gln Ser Gln Val Met Ala Cys Gly Asp Glu Ala Asn Asp Leu 
    210                 215                 220                 

Ser Met Ile Glu Trp Ala Gly Leu Gly Val Ala Met Gln Asn Ala Val 
225                 230                 235                 240 

Pro Glu Val Lys Ala Ala Ala Asn Val Val Thr Pro Met Thr Asn Asp 
                245                 250                 255     

Glu Glu Ala Val Ala Trp Ala Ile Glu Glu Tyr Val Leu Lys Glu Asn 
            260                 265                 270         


<210>   2503
<211>   792
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2503
atgacaatta aactagtagc aacggatatg gacggaacct tcctagatgg gaatggacgc   60
tttgatatgg atcgtctcaa gtctctcttg gtttcctaca aggaaaaagg gatttacttt   120
gcggtagctt cgggtcgggg atttctgtct ctagaaaaat tatttgctgg tgttcgtgat   180
gacattattt tcatcgcgga aaatggcagt ttggtagagt atcaaggtca ggacttgtat   240
gaagcgacta tgtctcgtga cttttatctg gcaacttttg aaaagctgaa aacttcacct   300
tatgtagata tcaataaact gctcttgacg ggtaagaagg gttcatatgt tctagatacg   360
gttgatgaga cctatttgaa agtgagtcag cactataatg aaaatatcca aaaagtagcg   420
agtttggaag atatcacaga tgacattttc aaatttacaa ccaacttcac agaagaaacg   480
ctggaagatg gggaggcttg ggtaaacgaa aacgttcctg gtgttaaggc catgacaact   540
ggctttgaat ccattgatat tgttctggac tatgtcgata agggagtggc cattgttgaa   600
ttagttaaaa aacttggtat cacaatggat caggtcatgg cttttggaga caatcttaat   660
gacttacata tgatgcaggt tgtgggacat cctgtagctc ctgaaaatgc acgacctgaa   720
attttagaat tagcaaagac tgtgattggt caccataagg aacggtcggt tatagcttat   780
atggagggct ta                                                       792

<210>   2504
<211>   264
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Cof family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903168 (e-146)

<400>   2504
Met Thr Ile Lys Leu Val Ala Thr Asp Met Asp Gly Thr Phe Leu Asp 
1               5                   10                  15      

Gly Asn Gly Arg Phe Asp Met Asp Arg Leu Lys Ser Leu Leu Val Ser 
            20                  25                  30          

Tyr Lys Glu Lys Gly Ile Tyr Phe Ala Val Ala Ser Gly Arg Gly Phe 
        35                  40                  45              

Leu Ser Leu Glu Lys Leu Phe Ala Gly Val Arg Asp Asp Ile Ile Phe 
    50                  55                  60                  

Ile Ala Glu Asn Gly Ser Leu Val Glu Tyr Gln Gly Gln Asp Leu Tyr 
65                  70                  75                  80  

Glu Ala Thr Met Ser Arg Asp Phe Tyr Leu Ala Thr Phe Glu Lys Leu 
                85                  90                  95      

Lys Thr Ser Pro Tyr Val Asp Ile Asn Lys Leu Leu Leu Thr Gly Lys 
            100                 105                 110         

Lys Gly Ser Tyr Val Leu Asp Thr Val Asp Glu Thr Tyr Leu Lys Val 
        115                 120                 125             

Ser Gln His Tyr Asn Glu Asn Ile Gln Lys Val Ala Ser Leu Glu Asp 
    130                 135                 140                 

Ile Thr Asp Asp Ile Phe Lys Phe Thr Thr Asn Phe Thr Glu Glu Thr 
145                 150                 155                 160 

Leu Glu Asp Gly Glu Ala Trp Val Asn Glu Asn Val Pro Gly Val Lys 
                165                 170                 175     

Ala Met Thr Thr Gly Phe Glu Ser Ile Asp Ile Val Leu Asp Tyr Val 
            180                 185                 190         

Asp Lys Gly Val Ala Ile Val Glu Leu Val Lys Lys Leu Gly Ile Thr 
        195                 200                 205             

Met Asp Gln Val Met Ala Phe Gly Asp Asn Leu Asn Asp Leu His Met 
    210                 215                 220                 

Met Gln Val Val Gly His Pro Val Ala Pro Glu Asn Ala Arg Pro Glu 
225                 230                 235                 240 

Ile Leu Glu Leu Ala Lys Thr Val Ile Gly His His Lys Glu Arg Ser 
                245                 250                 255     

Val Ile Ala Tyr Met Glu Gly Leu 
            260                 

<210>   2505
<211>   3537
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2505
atgtatttaa aggaaatcga aattcagggg ttcaagtctt ttgctgataa gaccaaggtc   60
gtttttgacc aaggtgtgac ggcagttgtt ggacccaatg gatctggaaa gtccaatatt   120
acagaaagtc tgcgttgggc tttgggggag tctagtgtca agagtctccg tgggggcaag   180
atgccggata tcatctttgc tggaaccgaa agtcgcaaac cgctcaatta tgcttctgta   240
gttgtgactc tggataatca tgacggattt atcaaggatg caggtcaaga aatcagggtg   300
gaacgccatg tctatcgtag tggagatagc gaatacaaga ttgacggcaa gaaagtccgt   360
ctgcgtgata ttcatgacct cttcttggat actggattgg gacgagattc cttctctatt   420
atttcccaag ggaaggttga ggagattttt aattccaagc ctgaggaacg acgagctatt   480
tttgaagaag ctgctggagt tttaaaatac aagactcgca gaaaagaaac cgagagtaaa   540
ctgcagcaaa ctcaggataa tctggaccgc ttagaggaca ttatctacga gttggataat   600
caaatcaagc ctcttgagaa gcaagctgag aatgcccgta agtttttaga cttggaagga   660
caacgtaagg ctatttattt agatgttctg gttgctcaaa tcaaggaaaa taaggctgaa   720
ctagagtcga cagaagaaga gttgactcag gttcaagaac tcttgatgag ttattaccaa   780
aagcgtgaaa aattagaaga agaaaatcaa actcttaaaa agcaacgcca agatttacag   840
gctgaaatgg ccaaagacca aggcagtttg atggacttga ctagtctgat tagtgattta   900
gaaagaaaat tagccctatc gaaactggag tccgagcaag tggccttgaa tcaacaggag   960
gcacaagccc gtttggctgc tttggaggat aagagaaatt cactcagcaa agaaaagtct   1020
gataaagaaa gctctttagc tctgttagag ggaaatctag tccaaaataa tcaaaaactc   1080
aatcgtttag aagctgaatt gctggctttc tcagacgatc ctgatcagat gattgagctc   1140
ttacgtgaac gctttgtagc tcttttacaa gaagaagcgg atgtctcaaa ccagttgacc   1200
cgtattgaga atgagttgga aaatagtcgt cagctttctc aaaaacaagc agatcaacta   1260
gaaaagctga aagagcaatt agctatagct aaagagaagg ctagtcagca aaaggaagag   1320
cttgaaactg ccaaggagca ggttcagaaa ttattggctg actaccaagc tattgccaag   1380
gagcaagagg agcagaaaac ttcctatcaa gctcaacaaa gccaactctt tgaccgtctg   1440
gataatctca aaaacaagca ggccagagct caaagtttgg aaaatatcct gagaaatcat   1500
agtaactttt atgcaggtgt taagagtgtt ctccaagaaa aagatcgcct aggtgggatt   1560
attggtgcag tcagtgagca tctgaccttt gatgtttatt atcaaactgc cctagagatt   1620
gccttagggg caagtagcca gcatatcatc gtagaagatg aagagtcggc aaccaaggct   1680
attgacttcc ttaaacggaa cagagccggt cgtgcaacct ttcttccttt gaccactatc   1740
aaggcgcgta cgatttctag tcagaaccaa gatgctatcg ctgtaagccc aggtttcctt   1800
gggatggcag atgagttggt gacttttgat actagactgg aagccatttt caagaacttg   1860
ctagctacga cggctatctt tgataccgta gaacatgcgc gtgcagcagc tcgccaagtt   1920
cgttatcagg ttcgtatggt gacattggat gggacagagt tgcgcacagg tggttcttat   1980
gcaggtggtg ccaatcgcca gaataacagc atttttatca agccagaact ggagcaatta   2040

caaaaagaaa ttgctgaaga agaagcaagc ttgggttcag aagaggcgac tttgaagacc   2100
ttgcaagatg agatggccag attgaccgag tcattagaag ctattaaatc tcaaggagag   2160
caggcacgta ttcaggagca aggcttgttc ctcgcttatc agcaaactag tcagcaagtt   2220
gaagaactgg aaactctttg gaaactccaa gaagaggaaa tagatcgtct ttccgaggga   2280
gattggcaag cggataagga aaactgccaa gagcgtcttg ctgcaatctc cagtgacaag   2340
caaaatctgg aagctgagat tgaagagatt aagtctaaca aaaatgccat ccaagaacgc   2400
tatcaaaact tgcaggaaga gctagcgcaa gctcgtttgc ttaagacaga actgcaaggg   2460
caaaaacgtt atgaagttgc tgatattgaa cgcttaggca aggaattgga caatcttgat   2520
tttgaacaag aggaaatcca gcgccttctt caagaaaaga ttgataatct tgagaaggtt   2580
gatacagaat tgctcagtca acaggcggaa gaatccaaaa ctcaaaaaac aaatctccaa   2640
caaggtttga ttcgcaagca gtttgagttg gatgatattg agggtcaact ggatgatatt   2700
gctagtcatt tggatcaggc tcgccagcag aatgaagagt ggattcgcaa gcaaactcgt   2760
gctgaagcca agaaagaaaa ggttagcgag cgcttgcgcc atctacaaag tcaattaaca   2820
gaccagtacc agatcagcta cacagaagct ttagaaaagg cgcatgagtt ggaaaatctc   2880
aatctggcag agcaagaagt taaggattta gagaaggcta tacgctcact gggtcctgtc   2940
aatttagacg ctattgaaca gtacgaagaa gttcacaacc gtctggattt cctaaatagc   3000
caacgtgatg atattttgtc tgcgaaaaac ctgctccttg agaccattac agagatgaat   3060
gatgaggtca aggaacgctt taaatcaacc tttgaggtca ttcgtgagtc ctttaaagtg   3120
accttcaagc agatgtttgg tggaggtcag gctgacctca ttttgactga aggagacttg   3180
ctgacagctg gggttgaaat ttctgtccaa ccaccaggca agaaaatcca gtctcttaat   3240
ctcatgagtg gtggtgaaaa agccctatcg gctcttgcct tgctcttctc cattattcgt   3300
gtcaagacta ttccatttgt tatcttggat gaggtggaag ctgcgctgga tgaagccaat   3360
gttaaacgtt ttggggatta cctcaaccgc tttgacaagg acagccagtt catcgtcgta   3420
acccaccgta agggaaccat ggcagcggct gattccatct atggagtgac catgcaagaa   3480
tcgggtgttt caaagattgt ttcagttaag ttaaaagatt tagaaagtat tgaagga      3537

<210>   2506
<211>   1179
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein ()
<223>   Cellular location: membrane
<223>   Feature of note: similar to LF and M prt
<223>   Similar to strain R6 sequence 15903169 (0.E+01)

<400>   2506
Met Tyr Leu Lys Glu Ile Glu Ile Gln Gly Phe Lys Ser Phe Ala Asp 
1               5                   10                  15      

Lys Thr Lys Val Val Phe Asp Gln Gly Val Thr Ala Val Val Gly Pro 
            20                  25                  30          

Asn Gly Ser Gly Lys Ser Asn Ile Thr Glu Ser Leu Arg Trp Ala Leu 
        35                  40                  45              

Gly Glu Ser Ser Val Lys Ser Leu Arg Gly Gly Lys Met Pro Asp Ile 
    50                  55                  60                  

Ile Phe Ala Gly Thr Glu Ser Arg Lys Pro Leu Asn Tyr Ala Ser Val 
65                  70                  75                  80  

Val Val Thr Leu Asp Asn His Asp Gly Phe Ile Lys Asp Ala Gly Gln 
                85                  90                  95      

Glu Ile Arg Val Glu Arg His Val Tyr Arg Ser Gly Asp Ser Glu Tyr 
            100                 105                 110         

Lys Ile Asp Gly Lys Lys Val Arg Leu Arg Asp Ile His Asp Leu Phe 
        115                 120                 125             

Leu Asp Thr Gly Leu Gly Arg Asp Ser Phe Ser Ile Ile Ser Gln Gly 
    130                 135                 140                 

Lys Val Glu Glu Ile Phe Asn Ser Lys Pro Glu Glu Arg Arg Ala Ile 
145                 150                 155                 160 

Phe Glu Glu Ala Ala Gly Val Leu Lys Tyr Lys Thr Arg Arg Lys Glu 
                165                 170                 175     

Thr Glu Ser Lys Leu Gln Gln Thr Gln Asp Asn Leu Asp Arg Leu Glu 
            180                 185                 190         

Asp Ile Ile Tyr Glu Leu Asp Asn Gln Ile Lys Pro Leu Glu Lys Gln 
        195                 200                 205             

Ala Glu Asn Ala Arg Lys Phe Leu Asp Leu Glu Gly Gln Arg Lys Ala 
    210                 215                 220                 

Ile Tyr Leu Asp Val Leu Val Ala Gln Ile Lys Glu Asn Lys Ala Glu 
225                 230                 235                 240 

Leu Glu Ser Thr Glu Glu Glu Leu Thr Gln Val Gln Glu Leu Leu Met 
                245                 250                 255     

Ser Tyr Tyr Gln Lys Arg Glu Lys Leu Glu Glu Glu Asn Gln Thr Leu 
            260                 265                 270         

Lys Lys Gln Arg Gln Asp Leu Gln Ala Glu Met Ala Lys Asp Gln Gly 
        275                 280                 285             

Ser Leu Met Asp Leu Thr Ser Leu Ile Ser Asp Leu Glu Arg Lys Leu 
    290                 295                 300                 

Ala Leu Ser Lys Leu Glu Ser Glu Gln Val Ala Leu Asn Gln Gln Glu 
305                 310                 315                 320 

Ala Gln Ala Arg Leu Ala Ala Leu Glu Asp Lys Arg Asn Ser Leu Ser 
                325                 330                 335     

Lys Glu Lys Ser Asp Lys Glu Ser Ser Leu Ala Leu Leu Glu Gly Asn 
            340                 345                 350         

Leu Val Gln Asn Asn Gln Lys Leu Asn Arg Leu Glu Ala Glu Leu Leu 
        355                 360                 365             

Ala Phe Ser Asp Asp Pro Asp Gln Met Ile Glu Leu Leu Arg Glu Arg 
    370                 375                 380                 

Phe Val Ala Leu Leu Gln Glu Glu Ala Asp Val Ser Asn Gln Leu Thr 
385                 390                 395                 400 

Arg Ile Glu Asn Glu Leu Glu Asn Ser Arg Gln Leu Ser Gln Lys Gln 
                405                 410                 415     

Ala Asp Gln Leu Glu Lys Leu Lys Glu Gln Leu Ala Ile Ala Lys Glu 
            420                 425                 430         

Lys Ala Ser Gln Gln Lys Glu Glu Leu Glu Thr Ala Lys Glu Gln Val 
        435                 440                 445             

Gln Lys Leu Leu Ala Asp Tyr Gln Ala Ile Ala Lys Glu Gln Glu Glu 
    450                 455                 460                 

Gln Lys Thr Ser Tyr Gln Ala Gln Gln Ser Gln Leu Phe Asp Arg Leu 
465                 470                 475                 480 

Asp Asn Leu Lys Asn Lys Gln Ala Arg Ala Gln Ser Leu Glu Asn Ile 
                485                 490                 495     


Leu Arg Asn His Ser Asn Phe Tyr Ala Gly Val Lys Ser Val Leu Gln 
            500                 505                 510         

Glu Lys Asp Arg Leu Gly Gly Ile Ile Gly Ala Val Ser Glu His Leu 
        515                 520                 525             

Thr Phe Asp Val Tyr Tyr Gln Thr Ala Leu Glu Ile Ala Leu Gly Ala 
    530                 535                 540                 

Ser Ser Gln His Ile Ile Val Glu Asp Glu Glu Ser Ala Thr Lys Ala 
545                 550                 555                 560 

Ile Asp Phe Leu Lys Arg Asn Arg Ala Gly Arg Ala Thr Phe Leu Pro 
                565                 570                 575     

Leu Thr Thr Ile Lys Ala Arg Thr Ile Ser Ser Gln Asn Gln Asp Ala 
            580                 585                 590         

Ile Ala Val Ser Pro Gly Phe Leu Gly Met Ala Asp Glu Leu Val Thr 
        595                 600                 605             

Phe Asp Thr Arg Leu Glu Ala Ile Phe Lys Asn Leu Leu Ala Thr Thr 
    610                 615                 620                 

Ala Ile Phe Asp Thr Val Glu His Ala Arg Ala Ala Ala Arg Gln Val 
625                 630                 635                 640 

Arg Tyr Gln Val Arg Met Val Thr Leu Asp Gly Thr Glu Leu Arg Thr 
                645                 650                 655     

Gly Gly Ser Tyr Ala Gly Gly Ala Asn Arg Gln Asn Asn Ser Ile Phe 
            660                 665                 670         

Ile Lys Pro Glu Leu Glu Gln Leu Gln Lys Glu Ile Ala Glu Glu Glu 
        675                 680                 685             

Ala Ser Leu Gly Ser Glu Glu Ala Thr Leu Lys Thr Leu Gln Asp Glu 
    690                 695                 700                 

Met Ala Arg Leu Thr Glu Ser Leu Glu Ala Ile Lys Ser Gln Gly Glu 
705                 710                 715                 720 

Gln Ala Arg Ile Gln Glu Gln Gly Leu Phe Leu Ala Tyr Gln Gln Thr 
                725                 730                 735     

Ser Gln Gln Val Glu Glu Leu Glu Thr Leu Trp Lys Leu Gln Glu Glu 
            740                 745                 750         

Glu Ile Asp Arg Leu Ser Glu Gly Asp Trp Gln Ala Asp Lys Glu Asn 
        755                 760                 765             

Cys Gln Glu Arg Leu Ala Ala Ile Ser Ser Asp Lys Gln Asn Leu Glu 
    770                 775                 780                 

Ala Glu Ile Glu Glu Ile Lys Ser Asn Lys Asn Ala Ile Gln Glu Arg 
785                 790                 795                 800 

Tyr Gln Asn Leu Gln Glu Glu Leu Ala Gln Ala Arg Leu Leu Lys Thr 
                805                 810                 815     

Glu Leu Gln Gly Gln Lys Arg Tyr Glu Val Ala Asp Ile Glu Arg Leu 
            820                 825                 830         


Gly Lys Glu Leu Asp Asn Leu Asp Phe Glu Gln Glu Glu Ile Gln Arg 
        835                 840                 845             

Leu Leu Gln Glu Lys Ile Asp Asn Leu Glu Lys Val Asp Thr Glu Leu 
    850                 855                 860                 

Leu Ser Gln Gln Ala Glu Glu Ser Lys Thr Gln Lys Thr Asn Leu Gln 
865                 870                 875                 880 

Gln Gly Leu Ile Arg Lys Gln Phe Glu Leu Asp Asp Ile Glu Gly Gln 
                885                 890                 895     

Leu Asp Asp Ile Ala Ser His Leu Asp Gln Ala Arg Gln Gln Asn Glu 
            900                 905                 910         

Glu Trp Ile Arg Lys Gln Thr Arg Ala Glu Ala Lys Lys Glu Lys Val 
        915                 920                 925             

Ser Glu Arg Leu Arg His Leu Gln Ser Gln Leu Thr Asp Gln Tyr Gln 
    930                 935                 940                 

Ile Ser Tyr Thr Glu Ala Leu Glu Lys Ala His Glu Leu Glu Asn Leu 
945                 950                 955                 960 

Asn Leu Ala Glu Gln Glu Val Lys Asp Leu Glu Lys Ala Ile Arg Ser 
                965                 970                 975     

Leu Gly Pro Val Asn Leu Asp Ala Ile Glu Gln Tyr Glu Glu Val His 
            980                 985                 990         

Asn Arg Leu Asp Phe Leu Asn Ser Gln Arg Asp Asp Ile Leu Ser Ala 
        995                 1000                1005            

Lys Asn Leu Leu Leu Glu Thr Ile Thr Glu Met Asn Asp Glu Val Lys 
    1010                1015                1020                

Glu Arg Phe Lys Ser Thr Phe Glu Val Ile Arg Glu Ser Phe Lys Val 
1025                1030                1035                1040

Thr Phe Lys Gln Met Phe Gly Gly Gly Gln Ala Asp Leu Ile Leu Thr 
                1045                1050                1055    

Glu Gly Asp Leu Leu Thr Ala Gly Val Glu Ile Ser Val Gln Pro Pro 
            1060                1065                1070        

Gly Lys Lys Ile Gln Ser Leu Asn Leu Met Ser Gly Gly Glu Lys Ala 
        1075                1080                1085            

Leu Ser Ala Leu Ala Leu Leu Phe Ser Ile Ile Arg Val Lys Thr Ile 
    1090                1095                1100                

Pro Phe Val Ile Leu Asp Glu Val Glu Ala Ala Leu Asp Glu Ala Asn 
1105                1110                1115                1120

Val Lys Arg Phe Gly Asp Tyr Leu Asn Arg Phe Asp Lys Asp Ser Gln 
                1125                1130                1135    

Phe Ile Val Val Thr His Arg Lys Gly Thr Met Ala Ala Ala Asp Ser 
            1140                1145                1150        

Ile Tyr Gly Val Thr Met Gln Glu Ser Gly Val Ser Lys Ile Val Ser 
        1155                1160                1165            

Val Lys Leu Lys Asp Leu Glu Ser Ile Glu Gly 
    1170                1175                

<210>   2507
<211>   696
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2507
atgaaagaat tacaaactgt actaaagaat cattttgcaa tcgaatttgc agacaaaaag   60
ttactggaaa ctgcctttac tcatacgagt tatgccaatg agcaccgcct cttaaaaatt   120
tcacacaatg aacgcttgga atttttagga gacgctgttc tacagttatt gatttcagaa   180
tatctatata aaaaatatcc taaaaagcct gaaggtgacc tatcaaaact ccgtgctatg   240
attgtccgtg aggagagttt agctggtttt gcgcgtgatt gccagtttga ccagtttatc   300
aagttgggta aaggggaaga aaaatcaggt ggtcgcaatc gtgacaccat tcttggtgat   360
gcctttgaag cctttcttgg tgcccttctt ttggataagg atgtggccaa ggtcaaggaa   420
tttatctatc aagtcatgat tcctaaggtt gaagcaggcg agtttgagat gattacagac   480
tataaaaccc atctccaaga gttgcttcag gtcaatggtg atgtggctat tcgttatcag   540
gtgatttctg aaacagggcc tgctcacgat aaggtttttg atgtagaagt tcttgttgaa   600
ggtaagagca tcggtcaagg ccaaggtcgt tctaagaaat tagcagagca ggaagctgcc   660
aaaaatgccg ttgagaaggg gctggattca tgtatt                             696

<210>   2508
<211>   232
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribonuclease III (rnc)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903170 (e-129)

<400>   2508
Met Lys Glu Leu Gln Thr Val Leu Lys Asn His Phe Ala Ile Glu Phe 
1               5                   10                  15      

Ala Asp Lys Lys Leu Leu Glu Thr Ala Phe Thr His Thr Ser Tyr Ala 
            20                  25                  30          

Asn Glu His Arg Leu Leu Lys Ile Ser His Asn Glu Arg Leu Glu Phe 
        35                  40                  45              

Leu Gly Asp Ala Val Leu Gln Leu Leu Ile Ser Glu Tyr Leu Tyr Lys 
    50                  55                  60                  

Lys Tyr Pro Lys Lys Pro Glu Gly Asp Leu Ser Lys Leu Arg Ala Met 

65                  70                  75                  80  

Ile Val Arg Glu Glu Ser Leu Ala Gly Phe Ala Arg Asp Cys Gln Phe 
                85                  90                  95      

Asp Gln Phe Ile Lys Leu Gly Lys Gly Glu Glu Lys Ser Gly Gly Arg 
            100                 105                 110         

Asn Arg Asp Thr Ile Leu Gly Asp Ala Phe Glu Ala Phe Leu Gly Ala 
        115                 120                 125             

Leu Leu Leu Asp Lys Asp Val Ala Lys Val Lys Glu Phe Ile Tyr Gln 
    130                 135                 140                 

Val Met Ile Pro Lys Val Glu Ala Gly Glu Phe Glu Met Ile Thr Asp 
145                 150                 155                 160 

Tyr Lys Thr His Leu Gln Glu Leu Leu Gln Val Asn Gly Asp Val Ala 
                165                 170                 175     

Ile Arg Tyr Gln Val Ile Ser Glu Thr Gly Pro Ala His Asp Lys Val 
            180                 185                 190         

Phe Asp Val Glu Val Leu Val Glu Gly Lys Ser Ile Gly Gln Gly Gln 
        195                 200                 205             

Gly Arg Ser Lys Lys Leu Ala Glu Gln Glu Ala Ala Lys Asn Ala Val 
    210                 215                 220                 

Glu Lys Gly Leu Asp Ser Cys Ile 
225                 230         

<210>   2509
<211>   984
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2509
atgttaaatg aatttccaat ttttgattac gaagatattc aattgattcc aaataaatgt   60
gtcattaaaa gccgtgcaga agcggataca agtgtcactt taggaaatca cacctttaaa   120
ctacctgttg tgccagcgaa tatgcagacg attttggatg aaaatgtagc agagcaactg   180
gctaaaggtg gttacttcta cattatgcac cgttttgatg aggcaggacg cattcctttt   240
attaaacgaa tgcacaatca agggctcatt gcttctatct ctgtcggtgt taaggattat   300
gagtatgatt ttgttagcca gctcaaggct gatactcctg agtatatcac tattgatatt   360
gctcatggtc atgcggatag cgtgatttct atgattcaac acatcaagaa agaattgcca   420
gatacctttg tcattgctgg aaatgtggga acaccagaag ctgtgcgtga attggaaaat   480
gctggtgcgg atgctactaa ggtcggaatc ggtcctggta aggtttgtat caccaaggtt   540
aagactggtt ttggtacagg tggttggcag ttggctgctc tacgctggtg tgccaaggct   600
gcgcgtaaac cgattatcgc tgatggagga attcgtactc acggtgatat tgctaagtct   660
atccgcttcg gtgctagcat gatcatgatt ggttccctct ttgcaggaca cattgaaagt   720
ccagggaaaa cgattgaagt cgatggtgaa cagttcaaag aatattatgg ttcagcctca   780
caatatcaaa aaggtgctta caaaaatgtg gaaggcaaac gtatcttgct tcctgctaaa   840
ggtcatctgc aagacacttt aactgagatg gaacaagacc ttcaaagtgc tatttcttat   900
gcaggtggac gtcaggttgc tgaccttaaa cacgttgatt atgtgatcgt gaaaaactcc   960
atctggaatg gggatgcttc ccac                                          984

<210>   2510
<211>   328
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903171 (0.E+01)

<400>   2510
Met Leu Asn Glu Phe Pro Ile Phe Asp Tyr Glu Asp Ile Gln Leu Ile 
1               5                   10                  15      

Pro Asn Lys Cys Val Ile Lys Ser Arg Ala Glu Ala Asp Thr Ser Val 
            20                  25                  30          

Thr Leu Gly Asn His Thr Phe Lys Leu Pro Val Val Pro Ala Asn Met 
        35                  40                  45              

Gln Thr Ile Leu Asp Glu Asn Val Ala Glu Gln Leu Ala Lys Gly Gly 
    50                  55                  60                  

Tyr Phe Tyr Ile Met His Arg Phe Asp Glu Ala Gly Arg Ile Pro Phe 
65                  70                  75                  80  

Ile Lys Arg Met His Asn Gln Gly Leu Ile Ala Ser Ile Ser Val Gly 
                85                  90                  95      

Val Lys Asp Tyr Glu Tyr Asp Phe Val Ser Gln Leu Lys Ala Asp Thr 
            100                 105                 110         

Pro Glu Tyr Ile Thr Ile Asp Ile Ala His Gly His Ala Asp Ser Val 
        115                 120                 125             

Ile Ser Met Ile Gln His Ile Lys Lys Glu Leu Pro Asp Thr Phe Val 
    130                 135                 140                 

Ile Ala Gly Asn Val Gly Thr Pro Glu Ala Val Arg Glu Leu Glu Asn 
145                 150                 155                 160 

Ala Gly Ala Asp Ala Thr Lys Val Gly Ile Gly Pro Gly Lys Val Cys 
                165                 170                 175     

Ile Thr Lys Val Lys Thr Gly Phe Gly Thr Gly Gly Trp Gln Leu Ala 
            180                 185                 190         

Ala Leu Arg Trp Cys Ala Lys Ala Ala Arg Lys Pro Ile Ile Ala Asp 
        195                 200                 205             

Gly Gly Ile Arg Thr His Gly Asp Ile Ala Lys Ser Ile Arg Phe Gly 
    210                 215                 220                 

Ala Ser Met Ile Met Ile Gly Ser Leu Phe Ala Gly His Ile Glu Ser 
225                 230                 235                 240 

Pro Gly Lys Thr Ile Glu Val Asp Gly Glu Gln Phe Lys Glu Tyr Tyr 
                245                 250                 255     

Gly Ser Ala Ser Gln Tyr Gln Lys Gly Ala Tyr Lys Asn Val Glu Gly 
            260                 265                 270         

Lys Arg Ile Leu Leu Pro Ala Lys Gly His Leu Gln Asp Thr Leu Thr 
        275                 280                 285             

Glu Met Glu Gln Asp Leu Gln Ser Ala Ile Ser Tyr Ala Gly Gly Arg 
    290                 295                 300                 

Gln Val Ala Asp Leu Lys His Val Asp Tyr Val Ile Val Lys Asn Ser 
305                 310                 315                 320 

Ile Trp Asn Gly Asp Ala Ser His 
                325             

<210>   2511
<211>   1326
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2511
atgaaaacga tgatgcggat tactgataat caacacaaga ttattaaaga aaaatttgtt   60
gaagaatatc ctaaactaag caatcctctt ttagacagaa ccttggaaag tctatcccaa   120
gatgaacgta ttttcatttt tccaaatgat ttgactcata ctcctgattt ggataaggac   180
caaaagattt ttgaaacagt caatcagaaa atcaagacag ggaacgtgat tggttttctt   240
ggatatggtc aggaaagatt aacgatttcc tcacgatttt ctgatgagag taatgaccac   300
tttttgcatt atctcttaaa caaggttctt catatcaatc tcactagttt agatgttgct   360
ttgtctcgtg aagagaggct ttatcaactt ttggtgtatc tctttcccaa gtatctacaa   420
gctgctattc gaaaaggtct ttataaggaa tatcatcgat tttctcataa cgacagtcat   480
gttaagggag tgattgatgt aagaaaccat ctcaagaaaa atcttccttt cacgggaaat   540
attgcctacg caacgagaga gttcacctat gataatcccc tcatgcagtt ggtccgtcac   600
actattgaat acattaagaa tcagaaaagc attggtcaag gggtactaga taatctctca   660
actagtcgtg aaaacgtatc tgaaatcgtg cgtgtaacgc cctcttataa actagctgat   720
cgtgctaaga ttattcgggg aaatcaatct aaacctatac gtcatgcata ctttcacgag   780
tacagaaact tacaagaact ttgtctgatg atcctaaacc aagaaaagca cggtttaggg   840
tatcaagatc aaaaaatcta tggtattctc tttgatgttg cctggctttg ggaagagtat   900
gtttacacct tgttgccaaa aggttttgta catcccagaa ataaggataa gacggatgga   960
atttcagtat tttctgttgg gaaacgaaaa gtatatccag atttttatga cagagaacga   1020
aagattgttc tagatgcaaa atataaaaaa ctggaattga ctgaaaaagg aatcaaccgt   1080
gaggacttat tccagctgat ttcctattct tatattttaa aagctgagaa ggctggactg   1140
atttttccta gtatggagca gtcagtaaat agtgaaatag gaaaagtagc tggctatgga   1200
gctcaattga agaagtggtc tattcgaatc cctcagaatg cctcattcta tagtacattt   1260
tgtaaaatga tggaaaattc agaagaaaat tttaaagcga ttattgatga agaagtgggg   1320
agaaaa                                                              1326

<210>   2512
<211>   442
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903172 (0.E+01)

<400>   2512
Met Lys Thr Met Met Arg Ile Thr Asp Asn Gln His Lys Ile Ile Lys 
1               5                   10                  15      

Glu Lys Phe Val Glu Glu Tyr Pro Lys Leu Ser Asn Pro Leu Leu Asp 
            20                  25                  30          

Arg Thr Leu Glu Ser Leu Ser Gln Asp Glu Arg Ile Phe Ile Phe Pro 
        35                  40                  45              

Asn Asp Leu Thr His Thr Pro Asp Leu Asp Lys Asp Gln Lys Ile Phe 
    50                  55                  60                  

Glu Thr Val Asn Gln Lys Ile Lys Thr Gly Asn Val Ile Gly Phe Leu 
65                  70                  75                  80  

Gly Tyr Gly Gln Glu Arg Leu Thr Ile Ser Ser Arg Phe Ser Asp Glu 
                85                  90                  95      

Ser Asn Asp His Phe Leu His Tyr Leu Leu Asn Lys Val Leu His Ile 
            100                 105                 110         

Asn Leu Thr Ser Leu Asp Val Ala Leu Ser Arg Glu Glu Arg Leu Tyr 
        115                 120                 125             

Gln Leu Leu Val Tyr Leu Phe Pro Lys Tyr Leu Gln Ala Ala Ile Arg 
    130                 135                 140                 

Lys Gly Leu Tyr Lys Glu Tyr His Arg Phe Ser His Asn Asp Ser His 
145                 150                 155                 160 

Val Lys Gly Val Ile Asp Val Arg Asn His Leu Lys Lys Asn Leu Pro 
                165                 170                 175     

Phe Thr Gly Asn Ile Ala Tyr Ala Thr Arg Glu Phe Thr Tyr Asp Asn 
            180                 185                 190         

Pro Leu Met Gln Leu Val Arg His Thr Ile Glu Tyr Ile Lys Asn Gln 
        195                 200                 205             


Lys Ser Ile Gly Gln Gly Val Leu Asp Asn Leu Ser Thr Ser Arg Glu 
    210                 215                 220                 

Asn Val Ser Glu Ile Val Arg Val Thr Pro Ser Tyr Lys Leu Ala Asp 
225                 230                 235                 240 

Arg Ala Lys Ile Ile Arg Gly Asn Gln Ser Lys Pro Ile Arg His Ala 
                245                 250                 255     

Tyr Phe His Glu Tyr Arg Asn Leu Gln Glu Leu Cys Leu Met Ile Leu 
            260                 265                 270         

Asn Gln Glu Lys His Gly Leu Gly Tyr Gln Asp Gln Lys Ile Tyr Gly 
        275                 280                 285             

Ile Leu Phe Asp Val Ala Trp Leu Trp Glu Glu Tyr Val Tyr Thr Leu 
    290                 295                 300                 

Leu Pro Lys Gly Phe Val His Pro Arg Asn Lys Asp Lys Thr Asp Gly 
305                 310                 315                 320 

Ile Ser Val Phe Ser Val Gly Lys Arg Lys Val Tyr Pro Asp Phe Tyr 
                325                 330                 335     

Asp Arg Glu Arg Lys Ile Val Leu Asp Ala Lys Tyr Lys Lys Leu Glu 
            340                 345                 350         

Leu Thr Glu Lys Gly Ile Asn Arg Glu Asp Leu Phe Gln Leu Ile Ser 
        355                 360                 365             

Tyr Ser Tyr Ile Leu Lys Ala Glu Lys Ala Gly Leu Ile Phe Pro Ser 
    370                 375                 380                 

Met Glu Gln Ser Val Asn Ser Glu Ile Gly Lys Val Ala Gly Tyr Gly 
385                 390                 395                 400 

Ala Gln Leu Lys Lys Trp Ser Ile Arg Ile Pro Gln Asn Ala Ser Phe 
                405                 410                 415     

Tyr Ser Thr Phe Cys Lys Met Met Glu Asn Ser Glu Glu Asn Phe Lys 
            420                 425                 430         

Ala Ile Ile Asp Glu Glu Val Gly Arg Lys 
        435                 440         

<210>   2513
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2513
atggctccaa ctcaggataa gttttggaca ccagttcaat tattttatga ttttgcagat   60
aaggtccacc ttgatttgtc tgagaaacaa agtggttcca aaattctttc tgactat      117

<210>   2514
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2514
Met Ala Pro Thr Gln Asp Lys Phe Trp Thr Pro Val Gln Leu Phe Tyr 
1               5                   10                  15      

Asp Phe Ala Asp Lys Val His Leu Asp Leu Ser Glu Lys Gln Ser Gly 
            20                  25                  30          

Ser Lys Ile Leu Ser Asp Tyr 
        35                  

<210>   2515
<211>   1932
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2515
ttgatgaata aaagaaaagt tagtttagaa gatttttata aatggtatag tctaaataaa   60
gaagagttat taaataaggc aactgttggt gaaaagttta atgataaatt aaaagaagag   120
tttctccagg aatggccttt ggataggatt ttaacaatgt caatcgatga atatgtaata   180
ggaaagggac agcaaaataa gtctttatgc tacgctcttg agaagggaaa atacaaaaat   240
ctatttcttg gaatttctgg tggctcagct tcaaaatttg gtatttattg gaataaaaaa   300
acaaacaaat ataaagatca agctaataat gagatttcag agttggatca gcgattttca   360
aaattaaaat cagatttgta tgaaattatc aaagaaggta ttcgttttaa ctttgaaaat   420
cctatttttg atatgaaaag atcaacaaat gaatttattg gtcgttctgc tatggtgaca   480
aaattacttt gtatctatac tgagggagat cctttctttg gtgtaaatat taatagtcag   540
aaagaatttt ggaaccactt tgtttctcag acaaatcaag gtggacctta tctgcaaaat   600
cataaaataa ttgaactggt gtccaaaact tatcctgagt tggagccatc gaaattagga   660
actatgcttt ttgagtattc taagcttttt atggaaaata aggaagacaa tagtacaatg   720
gattcatcaa acaattttcg tcatcaatta actcaatctc tattaaagtc tccaaacctc   780
atcctccgcg gtgctcctgg cacgggaaaa acttatcttg ctaaagaaat tgctaaagaa   840
ttaacggatg gcaacgaaga tcaaatcgga tttgtacaat ttcacccatc atatgattat   900
acggattttg tagaaggttt aagaccagta tcaaatgggg atggagctat tgagtttagg   960
ctacaggacg gtatttttaa agatttttgt cagaaagcaa aagaaaccca attgattgga   1020
ggacaagata attttgatga ggcttgggat tcttacttag aatatataaa tgttgctgaa   1080
gaaaaagaat atataacaaa aacatcttac ttatctgtta atagtagaca aaatttgtca   1140
gtaaattatg atagtggtgt tccaggatgg tcactaccta gcaaatatgt ttacgagttg   1200
tataaagata aaaattataa taagcaagaa tactacaaaa gtggtggaaa aactgtccta   1260
gaaacattga gaaagagatt tggtttgaaa gactatgttt ccccaacaga aattgatact   1320
gataagaatt ttgtcttcat catcgatgag atcaatcgtg gggagatttc taagattttt   1380
ggcgaactct ttttctctat cgaccccggc tatcgtggtg aaaaaggaag tgtttctacc   1440
caatatgcaa atctacacga aactgatgaa aagttctata tccccgaaaa tgtttacatc   1500
atcggaacta tgaatgatat tgatcgttca gtggatacct ttgattttgc tatgcgtcgt   1560
cgttttcgtt ttgttgaagt tactgtcgag ggtcaagctg gcatgttgga taaagagttg   1620
aatatccatg cagaagaagc aaaaattcgt ctaagaaact tgaacgctgc tatcgaaaat   1680
attcaggaat taaacagtca ttatcatatt ggaccaagtt attttcttaa gttgaaggat   1740
gtagattttg actatgaatt actctggtct gattatatta agcctctcct agaagactac   1800
ttgcgaggtt cttatgatga ggttgaaact ttggaaactt tgaaaaaagc atttgatctg   1860
acaaataatg agcaaaaaga tcaggcagta gctgatgaca atgaaggcga tgaaaacgat   1920
gatgcggatt ac                                                       1932

<210>   2516
<211>   644
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   endonuclease, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903173 (0.E+01)

<400>   2516
Met Met Asn Lys Arg Lys Val Ser Leu Glu Asp Phe Tyr Lys Trp Tyr 
1               5                   10                  15      

Ser Leu Asn Lys Glu Glu Leu Leu Asn Lys Ala Thr Val Gly Glu Lys 
            20                  25                  30          

Phe Asn Asp Lys Leu Lys Glu Glu Phe Leu Gln Glu Trp Pro Leu Asp 
        35                  40                  45              

Arg Ile Leu Thr Met Ser Ile Asp Glu Tyr Val Ile Gly Lys Gly Gln 
    50                  55                  60                  

Gln Asn Lys Ser Leu Cys Tyr Ala Leu Glu Lys Gly Lys Tyr Lys Asn 
65                  70                  75                  80  

Leu Phe Leu Gly Ile Ser Gly Gly Ser Ala Ser Lys Phe Gly Ile Tyr 
                85                  90                  95      

Trp Asn Lys Lys Thr Asn Lys Tyr Lys Asp Gln Ala Asn Asn Glu Ile 
            100                 105                 110         

Ser Glu Leu Asp Gln Arg Phe Ser Lys Leu Lys Ser Asp Leu Tyr Glu 
        115                 120                 125             

Ile Ile Lys Glu Gly Ile Arg Phe Asn Phe Glu Asn Pro Ile Phe Asp 
    130                 135                 140                 

Met Lys Arg Ser Thr Asn Glu Phe Ile Gly Arg Ser Ala Met Val Thr 
145                 150                 155                 160 

Lys Leu Leu Cys Ile Tyr Thr Glu Gly Asp Pro Phe Phe Gly Val Asn 
                165                 170                 175     

Ile Asn Ser Gln Lys Glu Phe Trp Asn His Phe Val Ser Gln Thr Asn 
            180                 185                 190         

Gln Gly Gly Pro Tyr Leu Gln Asn His Lys Ile Ile Glu Leu Val Ser 
        195                 200                 205             

Lys Thr Tyr Pro Glu Leu Glu Pro Ser Lys Leu Gly Thr Met Leu Phe 
    210                 215                 220                 

Glu Tyr Ser Lys Leu Phe Met Glu Asn Lys Glu Asp Asn Ser Thr Met 
225                 230                 235                 240 

Asp Ser Ser Asn Asn Phe Arg His Gln Leu Thr Gln Ser Leu Leu Lys 
                245                 250                 255     

Ser Pro Asn Leu Ile Leu Arg Gly Ala Pro Gly Thr Gly Lys Thr Tyr 
            260                 265                 270         

Leu Ala Lys Glu Ile Ala Lys Glu Leu Thr Asp Gly Asn Glu Asp Gln 
        275                 280                 285             

Ile Gly Phe Val Gln Phe His Pro Ser Tyr Asp Tyr Thr Asp Phe Val 
    290                 295                 300                 

Glu Gly Leu Arg Pro Val Ser Asn Gly Asp Gly Ala Ile Glu Phe Arg 
305                 310                 315                 320 

Leu Gln Asp Gly Ile Phe Lys Asp Phe Cys Gln Lys Ala Lys Glu Thr 
                325                 330                 335     

Gln Leu Ile Gly Gly Gln Asp Asn Phe Asp Glu Ala Trp Asp Ser Tyr 
            340                 345                 350         

Leu Glu Tyr Ile Asn Val Ala Glu Glu Lys Glu Tyr Ile Thr Lys Thr 
        355                 360                 365             

Ser Tyr Leu Ser Val Asn Ser Arg Gln Asn Leu Ser Val Asn Tyr Asp 
    370                 375                 380                 

Ser Gly Val Pro Gly Trp Ser Leu Pro Ser Lys Tyr Val Tyr Glu Leu 
385                 390                 395                 400 

Tyr Lys Asp Lys Asn Tyr Asn Lys Gln Glu Tyr Tyr Lys Ser Gly Gly 
                405                 410                 415     

Lys Thr Val Leu Glu Thr Leu Arg Lys Arg Phe Gly Leu Lys Asp Tyr 
            420                 425                 430         

Val Ser Pro Thr Glu Ile Asp Thr Asp Lys Asn Phe Val Phe Ile Ile 
        435                 440                 445             

Asp Glu Ile Asn Arg Gly Glu Ile Ser Lys Ile Phe Gly Glu Leu Phe 
    450                 455                 460                 

Phe Ser Ile Asp Pro Gly Tyr Arg Gly Glu Lys Gly Ser Val Ser Thr 
465                 470                 475                 480 

Gln Tyr Ala Asn Leu His Glu Thr Asp Glu Lys Phe Tyr Ile Pro Glu 
                485                 490                 495     

Asn Val Tyr Ile Ile Gly Thr Met Asn Asp Ile Asp Arg Ser Val Asp 
            500                 505                 510         

Thr Phe Asp Phe Ala Met Arg Arg Arg Phe Arg Phe Val Glu Val Thr 
        515                 520                 525             


Val Glu Gly Gln Ala Gly Met Leu Asp Lys Glu Leu Asn Ile His Ala 
    530                 535                 540                 

Glu Glu Ala Lys Ile Arg Leu Arg Asn Leu Asn Ala Ala Ile Glu Asn 
545                 550                 555                 560 

Ile Gln Glu Leu Asn Ser His Tyr His Ile Gly Pro Ser Tyr Phe Leu 
                565                 570                 575     

Lys Leu Lys Asp Val Asp Phe Asp Tyr Glu Leu Leu Trp Ser Asp Tyr 
            580                 585                 590         

Ile Lys Pro Leu Leu Glu Asp Tyr Leu Arg Gly Ser Tyr Asp Glu Val 
        595                 600                 605             

Glu Thr Leu Glu Thr Leu Lys Lys Ala Phe Asp Leu Thr Asn Asn Glu 
    610                 615                 620                 

Gln Lys Asp Gln Ala Val Ala Asp Asp Asn Glu Gly Asp Glu Asn Asp 
625                 630                 635                 640 

Asp Ala Asp Tyr 
                

<210>   2517
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2517
atggtgtcta tggtcgataa ggacggcaaa ctcatcccag aacaaggagg agcacgttca   60
acttcaccag ctccagttgt gatccgtaaa gggcttgaca ttgataaaat catgatgcac   120
ctgtcagata cttttaactc atgggactac cgtcaggttg agtattat                168

<210>   2518
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903174 (4.E-29)

<400>   2518
Met Val Ser Met Val Asp Lys Asp Gly Lys Leu Ile Pro Glu Gln Gly 
1               5                   10                  15      

Gly Ala Arg Ser Thr Ser Pro Ala Pro Val Val Ile Arg Lys Gly Leu 
            20                  25                  30          

Asp Ile Asp Lys Ile Met Met His Leu Ser Asp Thr Phe Asn Ser Trp 
        35                  40                  45              

Asp Tyr Arg Gln Val Glu Tyr Tyr 
    50                  55      

<210>   2519
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2519
ttggctgcca agctttggga agaaggtaaa atggtctacg cctcatctgc ttcaatgaca   60
aaacgattga aactcgctat gagcaaggtg                                    90

<210>   2520
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903175 (3.E-09)

<400>   2520
Met Ala Ala Lys Leu Trp Glu Glu Gly Lys Met Val Tyr Ala Ser Ser 
1               5                   10                  15      

Ala Ser Met Thr Lys Arg Leu Lys Leu Ala Met Ser Lys Val 
            20                  25                  30  

<210>   2521
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2521
atgaccagtg acaaggcagg acttgagcgt aagttcgcag ccaaagaacg taagcgtaac   60
aaaccaggtg ttgttctctg cggtagcatg gatgaacttt gcgctttagc gcaactcaac   120
ccagaaattg aagcattcta c                                             141

<210>   2522
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2522
Met Thr Ser Asp Lys Ala Gly Leu Glu Arg Lys Phe Ala Ala Lys Glu 
1               5                   10                  15      

Arg Lys Arg Asn Lys Pro Gly Val Val Leu Cys Gly Ser Met Asp Glu 
            20                  25                  30          

Leu Cys Ala Leu Ala Gln Leu Asn Pro Glu Ile Glu Ala Phe Tyr 
        35                  40                  45          

<210>   2523
<211>   357
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2523
atggcagggt cttcgaggga atacgctgct tgggctctag cggactatgg ttttaaggtc   60
gtgattgcag gatctttcgg tgacattcat tacaataatg aactcaataa tggcatgttg   120
ccaatcgttc agcctagaga ggttagagag aaactagccc agctaaaacc aaccgaccag   180
gtaactgtgg acttggaaca acaaaaaatc atctcaccag ttgaagaatt caccttcgag   240
atagatagcg agtggaaaca taaactccta aatagtttgg atgatatcgg tattaccttg   300
cagtatgaag agttgattgc tgcttatgaa aaacaacgac cagcctactg gcaggat      357

<210>   2524
<211>   119
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-isopropylmalate dehydratase, small subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903176 (5.E-65)

<400>   2524
Met Ala Gly Ser Ser Arg Glu Tyr Ala Ala Trp Ala Leu Ala Asp Tyr 
1               5                   10                  15      

Gly Phe Lys Val Val Ile Ala Gly Ser Phe Gly Asp Ile His Tyr Asn 
            20                  25                  30          

Asn Glu Leu Asn Asn Gly Met Leu Pro Ile Val Gln Pro Arg Glu Val 
        35                  40                  45              

Arg Glu Lys Leu Ala Gln Leu Lys Pro Thr Asp Gln Val Thr Val Asp 
    50                  55                  60                  

Leu Glu Gln Gln Lys Ile Ile Ser Pro Val Glu Glu Phe Thr Phe Glu 
65                  70                  75                  80  

Ile Asp Ser Glu Trp Lys His Lys Leu Leu Asn Ser Leu Asp Asp Ile 
                85                  90                  95      

Gly Ile Thr Leu Gln Tyr Glu Glu Leu Ile Ala Ala Tyr Glu Lys Gln 
            100                 105                 110         

Arg Pro Ala Tyr Trp Gln Asp 
        115                 

<210>   2525
<211>   267
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2525
atgaagttag acgaaaaaat tactctagtc cttttgattt ggaatgtcat cattttcttg   60
atttatggta ttgacaaatc taaggcaagg agaagagttt ggcgcatccc tgagaaaatc   120
ttacttattt tagcctttac ttttggtggt tttggtgcct ggctagcagg aatcatcttt   180
caccacaaga ctcgaaaatg gtactttaaa atagtttggt ttcttgggat ggtgaccaca   240
ctagtagcct tatattttat ttggagg                                       267

<210>   2526
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903177 (3.E-45)

<400>   2526
Met Lys Leu Asp Glu Lys Ile Thr Leu Val Leu Leu Ile Trp Asn Val 
1               5                   10                  15      

Ile Ile Phe Leu Ile Tyr Gly Ile Asp Lys Ser Lys Ala Arg Arg Arg 
            20                  25                  30          

Val Trp Arg Ile Pro Glu Lys Ile Leu Leu Ile Leu Ala Phe Thr Phe 
        35                  40                  45              

Gly Gly Phe Gly Ala Trp Leu Ala Gly Ile Ile Phe His His Lys Thr 
    50                  55                  60                  

Arg Lys Trp Tyr Phe Lys Ile Val Trp Phe Leu Gly Met Val Thr Thr 
65                  70                  75                  80  

Leu Val Ala Leu Tyr Phe Ile Trp Arg 
                85                  

<210>   2527
<211>   789
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2527
gtggttcgcc ctgaacaagg cctgatggct ctccgtaagg aactcaatct ttacgctaat   60
attcgtcctg taaaaatctt tgacagtctc aagcatttgt caccactcaa actggaacga   120
attgctggtg tagactttgt cgtggtgcgt gaattgacag gcgggattta ctttggatat   180
catattcttg aagagcgcaa tgcgcgtgat atcaacgact atagctatga ggaagtggag   240
cggattattc gcaaagcctt tgaaattgca agaaatcgca gaaaaatcgt tactagtatc   300
gataagcaaa atgttctagc gacctcaaaa ctctggcgga aagtagctga ggaagtcgca   360
caggatttcc cagatgtaac cttggaacat cagctggtag actcagctgc tatgcttatg   420
attaccaatc ctgctaagtt tgatgttatt gtaacggaga atctttttgg agatatttta   480
tctgatgaat caagcgtctt atctggtaca cttggggtta tgccatcagc cagtcattct   540
gaaaatggac caagtctcta tgaacctatt cacggttcag cacctgatat tgcaggtcaa   600
ggaattgcca atcctatttc catgatttta tcagtttcca tgatgttgag agatagtttc   660
ggacgttatg aggatgcaga gcgtatcaaa cgtgctgttg agacaagtct ggcggcagga   720
attttaacga gagatatagg aggtcaggct tcaacaaagg aaatgacgga agctattatt   780
gcaaggtta                                                           789

<210>   2528
<211>   263
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-isopropylmalate dehydrogenase (ec 1.1.1.85) (beta-ipm dehydrogenase)

<400>   2528
Met Val Arg Pro Glu Gln Gly Leu Met Ala Leu Arg Lys Glu Leu Asn 
1               5                   10                  15      

Leu Tyr Ala Asn Ile Arg Pro Val Lys Ile Phe Asp Ser Leu Lys His 
            20                  25                  30          

Leu Ser Pro Leu Lys Leu Glu Arg Ile Ala Gly Val Asp Phe Val Val 
        35                  40                  45              

Val Arg Glu Leu Thr Gly Gly Ile Tyr Phe Gly Tyr His Ile Leu Glu 
    50                  55                  60                  

Glu Arg Asn Ala Arg Asp Ile Asn Asp Tyr Ser Tyr Glu Glu Val Glu 
65                  70                  75                  80  

Arg Ile Ile Arg Lys Ala Phe Glu Ile Ala Arg Asn Arg Arg Lys Ile 
                85                  90                  95      

Val Thr Ser Ile Asp Lys Gln Asn Val Leu Ala Thr Ser Lys Leu Trp 
            100                 105                 110         

Arg Lys Val Ala Glu Glu Val Ala Gln Asp Phe Pro Asp Val Thr Leu 
        115                 120                 125             

Glu His Gln Leu Val Asp Ser Ala Ala Met Leu Met Ile Thr Asn Pro 
    130                 135                 140                 

Ala Lys Phe Asp Val Ile Val Thr Glu Asn Leu Phe Gly Asp Ile Leu 
145                 150                 155                 160 

Ser Asp Glu Ser Ser Val Leu Ser Gly Thr Leu Gly Val Met Pro Ser 
                165                 170                 175     

Ala Ser His Ser Glu Asn Gly Pro Ser Leu Tyr Glu Pro Ile His Gly 
            180                 185                 190         

Ser Ala Pro Asp Ile Ala Gly Gln Gly Ile Ala Asn Pro Ile Ser Met 
        195                 200                 205             

Ile Leu Ser Val Ser Met Met Leu Arg Asp Ser Phe Gly Arg Tyr Glu 
    210                 215                 220                 

Asp Ala Glu Arg Ile Lys Arg Ala Val Glu Thr Ser Leu Ala Ala Gly 
225                 230                 235                 240 

Ile Leu Thr Arg Asp Ile Gly Gly Gln Ala Ser Thr Lys Glu Met Thr 
                245                 250                 255     

Glu Ala Ile Ile Ala Arg Leu 
            260             

<210>   2529
<211>   1035
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2529
atggcaaaga aaatagtagc tctagcagga gacggaattg gcccagaaat catggaggtt   60
ggtttagaag ttctggaggc tctagctgaa aaaacaggtt ttgactatga gattgacaga   120
cgaccgttcg gaggtgcaga tattgatgca gcatgacctc ccttacctga tgaaaccctt   180
aaggcaagta gggaagcaga tgctatccta ctagtagcta tcggtagtcc tcagtatgat   240
ggagcagtgg ttcgccctga acaaggcctg atggctctcc gtaaggaact caatctttac   300
gctaatattc gtcctgtaaa aatctttgac agtctcaagc atttgtcacc actcaaactg   360
gaacgaattg ctggtgtaga ctttgtcgtg gtgcgtgaat tgacaggcgg gatttacttt   420
ggatatcata ttcttgaaga gcgcaatgcg cgtgatatca acgactatag ctatgaggaa   480
gtggagcgga ttattcgcaa agcctttgaa attgcaagaa atcgcagaaa aatcgttact   540
agtatcgata agcaaaatgt tctagcgacc tcaaaactct ggcggaaagt agctgaggaa   600
gtcgcacagg atttcccaga tgtaaccttg gaacatcagc tggtagactc agctgctatg   660
cttatgatta ccaatcctgc taagtttgat gttattgtaa cggagaatct ttttggagat   720
attttatctg atgaatcaag cgtcttatct ggtacacttg gggttatgcc atcagccagt   780
cattctgaaa atggaccaag tctctatgaa cctattcacg gttcagcacc tgatattgca   840
ggtcaaggaa ttgccaatcc tatttccatg attttatcag tttccatgat gttgagagat   900
agtttcggac gttatgagga tgcagagcgt atcaaacgtg ctgttgagac aagtctggcg   960
gcaggaattt taacgagaga tataggaggt caggcttcaa caaaggaaat gacggaagct   1020
attattgcaa ggtta                                                    1035

<210>   2530
<211>   51
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-isopropylmalate dehydrogenase POINT MUTATION (leuB)

<400>   2530
Met Ala Lys Lys Ile Val Ala Leu Ala Gly Asp Gly Ile Gly Pro Glu 
1               5                   10                  15      

Ile Met Glu Val Gly Leu Glu Val Leu Glu Ala Leu Ala Glu Lys Thr 
            20                  25                  30          

Gly Phe Asp Tyr Glu Ile Asp Arg Arg Pro Phe Gly Gly Ala Asp Ile 
        35                  40                  45              

Asp Ala Ala 
    50      

<210>   2531
<211>   1092
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2531
atgaactttc aattagctaa atattcttta ctgaagagat ttttagaaaa tataggattt   60
accacactag aggaatatgg tgccatcttc aaatacctga ttgagaatgt caagacggat   120
cgtcagatca tctattcgcc tcactgtcat gatgacctcg gaatggcagt ggcaaatagc   180
cttgctgctg tcaagaatgg tgcaggacgt gttgaaggga ctatcaatgg tattagggag   240
cgagctgaaa atgctgcttt ggaagaaatt gcagtggctc tcaatattcg ccaagattac   300
taccaagtag aaaccagtat tgtcctaaat gagaccatca atacgtcaga aatggtttct   360
cgcttctctg gtattccagt tcctaaaaac aaagccgtcg ttggtggcaa taccttctcc   420
cacgaatctg gtattcacca agatggagtc cttaaaaatc ctctcactta tgagatcatc   480
acacctgaat tggttggtgt taagattctg cttggaaaat tatctggtcg ccatgctttt   540
gttgagaaac tgagagaatt ggccctagat tttacagaag aggatatcaa accactcttt   600
gctaagttca aggcactggt cgataagaag caagaaatca cagatgcaga tattcgagct   660
ttggtagctg gaaccatggt tgaaaatcca gaaggcttcc actttgatga tttacaactt   720
caaactcatg cagataatga cattgaagcg ctcgttagcc tagccaatat ggatggtgag   780
aaagtcgaat ttaatgcgac agggcaaggt tccgttgaag caatctttaa tgctatcgat   840
aagttcttta accaatctgt tcgtttggtg tcctacacta tcgatgcggt aacagatgga   900
atcgataccc aggatcgggt tttggtcact gttgaaaaca gagatacaga aaccatcttt   960
aatgcagcag ggcttgattt tgatgtgttg aaggcttctg ctattgtcta tataaacgct   1020
aatacctttg ttcaaaaaga gaatgcaggt gagatgggac gcagtgtttc ttaccacgat   1080
atgcctagtg tg                                                       1092

<210>   2532
<211>   364
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   2-isopropylmalate synthase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903180 (e-112)

<400>   2532
Met Asn Phe Gln Leu Ala Lys Tyr Ser Leu Leu Lys Arg Phe Leu Glu 
1               5                   10                  15      

Asn Ile Gly Phe Thr Thr Leu Glu Glu Tyr Gly Ala Ile Phe Lys Tyr 
            20                  25                  30          

Leu Ile Glu Asn Val Lys Thr Asp Arg Gln Ile Ile Tyr Ser Pro His 
        35                  40                  45              

Cys His Asp Asp Leu Gly Met Ala Val Ala Asn Ser Leu Ala Ala Val 
    50                  55                  60                  

Lys Asn Gly Ala Gly Arg Val Glu Gly Thr Ile Asn Gly Ile Arg Glu 
65                  70                  75                  80  

Arg Ala Glu Asn Ala Ala Leu Glu Glu Ile Ala Val Ala Leu Asn Ile 
                85                  90                  95      

Arg Gln Asp Tyr Tyr Gln Val Glu Thr Ser Ile Val Leu Asn Glu Thr 
            100                 105                 110         

Ile Asn Thr Ser Glu Met Val Ser Arg Phe Ser Gly Ile Pro Val Pro 
        115                 120                 125             

Lys Asn Lys Ala Val Val Gly Gly Asn Thr Phe Ser His Glu Ser Gly 
    130                 135                 140                 

Ile His Gln Asp Gly Val Leu Lys Asn Pro Leu Thr Tyr Glu Ile Ile 
145                 150                 155                 160 

Thr Pro Glu Leu Val Gly Val Lys Ile Leu Leu Gly Lys Leu Ser Gly 
                165                 170                 175     

Arg His Ala Phe Val Glu Lys Leu Arg Glu Leu Ala Leu Asp Phe Thr 
            180                 185                 190         

Glu Glu Asp Ile Lys Pro Leu Phe Ala Lys Phe Lys Ala Leu Val Asp 
        195                 200                 205             

Lys Lys Gln Glu Ile Thr Asp Ala Asp Ile Arg Ala Leu Val Ala Gly 
    210                 215                 220                 

Thr Met Val Glu Asn Pro Glu Gly Phe His Phe Asp Asp Leu Gln Leu 
225                 230                 235                 240 

Gln Thr His Ala Asp Asn Asp Ile Glu Ala Leu Val Ser Leu Ala Asn 
                245                 250                 255     

Met Asp Gly Glu Lys Val Glu Phe Asn Ala Thr Gly Gln Gly Ser Val 
            260                 265                 270         

Glu Ala Ile Phe Asn Ala Ile Asp Lys Phe Phe Asn Gln Ser Val Arg 
        275                 280                 285             

Leu Val Ser Tyr Thr Ile Asp Ala Val Thr Asp Gly Ile Asp Thr Gln 
    290                 295                 300                 

Asp Arg Val Leu Val Thr Val Glu Asn Arg Asp Thr Glu Thr Ile Phe 
305                 310                 315                 320 

Asn Ala Ala Gly Leu Asp Phe Asp Val Leu Lys Ala Ser Ala Ile Val 
                325                 330                 335     

Tyr Ile Asn Ala Asn Thr Phe Val Gln Lys Glu Asn Ala Gly Glu Met 
            340                 345                 350         

Gly Arg Ser Val Ser Tyr His Asp Met Pro Ser Val 
        355                 360                 

<210>   2533
<211>   333
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2533
atgactcaag ttcaggaaaa gtatggaaac cagttggagt atctgtggga aaaatcgcct   60
gatacagctg tattgcgcca tgaaggcaat caaaagtggt atgccgtctt gatgaaaatc   120
tcttggaata agctggaaaa gggcagagaa ggacaagtgg aagcagtcaa cctcaagcat   180
gaccaagtag ctaatttgct ttcacaaaag gggatttatc cagccttcca tatgagcaag   240
cgctactgga ttagtgtgtc ccttgatgat actttatcag atgaagaagt actggaattg   300
atagaaaaaa gttggaactt aacctctaaa aaa                                333

<210>   2534
<211>   111
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903181 (2.E-62)

<400>   2534
Met Thr Gln Val Gln Glu Lys Tyr Gly Asn Gln Leu Glu Tyr Leu Trp 
1               5                   10                  15      

Glu Lys Ser Pro Asp Thr Ala Val Leu Arg His Glu Gly Asn Gln Lys 
            20                  25                  30          

Trp Tyr Ala Val Leu Met Lys Ile Ser Trp Asn Lys Leu Glu Lys Gly 
        35                  40                  45              

Arg Glu Gly Gln Val Glu Ala Val Asn Leu Lys His Asp Gln Val Ala 
    50                  55                  60                  

Asn Leu Leu Ser Gln Lys Gly Ile Tyr Pro Ala Phe His Met Ser Lys 
65                  70                  75                  80  

Arg Tyr Trp Ile Ser Val Ser Leu Asp Asp Thr Leu Ser Asp Glu Glu 
                85                  90                  95      

Val Leu Glu Leu Ile Glu Lys Ser Trp Asn Leu Thr Ser Lys Lys 
            100                 105                 110     

<210>   2535
<211>   630
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2535
atgatttacg aattttgtgc tgaaaatgtg actttacttg aaaaagcgat gcaggctgga   60
gctcgtcgga ttgaactctg tgataatcta gcagttggtg ggacaacacc cagctatgga   120
gtgactaagg cagcggttga actggcagct aactacgata caaccatcat gaccatgatt   180
cggccacgtg gtggtgactt tgtctataat gacctagaaa ttgctatcat gctagaagac   240
attcgtttga ctgctcaggc tggaagtcaa ggggttgtat ttggagcttt aactgctgat   300
aaaaagttgg ataagcctaa tctggaaaag ttaattgctg catcaaaagg aatggaaatt   360
gtctttcaca tggcctttga tgaactaagt gatgaagatc aagcggaagc tattgactgg   420
ctcagtcaag ccggtgtcac tcgtatccta actcgtgctg gtgtgtctgg cgactcctta   480
gaaaaacgtt ttgttcacta tcacagaatt ttggagtacg ctaaaggtaa aattgaaatt   540
ctaccaggtg gggggattga ccttgaaaac cgtcaaacct ttatcgacca ggtgggggta   600
acacaattgc atggtactaa ggttgttttt                                    630

<210>   2536
<211>   210
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   copper homeostasis protein CutC (cutC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903182 (e-116)

<400>   2536
Met Ile Tyr Glu Phe Cys Ala Glu Asn Val Thr Leu Leu Glu Lys Ala 
1               5                   10                  15      

Met Gln Ala Gly Ala Arg Arg Ile Glu Leu Cys Asp Asn Leu Ala Val 
            20                  25                  30          

Gly Gly Thr Thr Pro Ser Tyr Gly Val Thr Lys Ala Ala Val Glu Leu 
        35                  40                  45              

Ala Ala Asn Tyr Asp Thr Thr Ile Met Thr Met Ile Arg Pro Arg Gly 
    50                  55                  60                  

Gly Asp Phe Val Tyr Asn Asp Leu Glu Ile Ala Ile Met Leu Glu Asp 
65                  70                  75                  80  

Ile Arg Leu Thr Ala Gln Ala Gly Ser Gln Gly Val Val Phe Gly Ala 
                85                  90                  95      

Leu Thr Ala Asp Lys Lys Leu Asp Lys Pro Asn Leu Glu Lys Leu Ile 
            100                 105                 110         

Ala Ala Ser Lys Gly Met Glu Ile Val Phe His Met Ala Phe Asp Glu 
        115                 120                 125             

Leu Ser Asp Glu Asp Gln Ala Glu Ala Ile Asp Trp Leu Ser Gln Ala 
    130                 135                 140                 

Gly Val Thr Arg Ile Leu Thr Arg Ala Gly Val Ser Gly Asp Ser Leu 
145                 150                 155                 160 

Glu Lys Arg Phe Val His Tyr His Arg Ile Leu Glu Tyr Ala Lys Gly 
                165                 170                 175     

Lys Ile Glu Ile Leu Pro Gly Gly Gly Ile Asp Leu Glu Asn Arg Gln 
            180                 185                 190         

Thr Phe Ile Asp Gln Val Gly Val Thr Gln Leu His Gly Thr Lys Val 
        195                 200                 205             

Val Phe 
    210 

<210>   2537
<211>   357
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2537
atgcgtatta tctatctaat tattggtttt ttatcgctga ccttggctat tgttggggtt   60
gttttaccct tgttgcctac aacacctttc cttttgttgt ctattgcttg tttctccaga   120
agttccaagc gattcgaaga ttggctttat cataccaagc tctatcaagc atatgtagct   180
gattttcgtg agaccaagtc tattgcgcgt gaacgaaaga aaaaaatcat cgtctctatc   240
tacgtcttga tgggaatttc tatttatttt gcacctcttt taccagtcaa aatcggtctg   300
ggtgctttga ccatctttat tacttattat ctcttcaagg tcattccaga caaagaa      357

<210>   2538
<211>   119

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903183 (1.E-61)

<400>   2538
Met Arg Ile Ile Tyr Leu Ile Ile Gly Phe Leu Ser Leu Thr Leu Ala 
1               5                   10                  15      

Ile Val Gly Val Val Leu Pro Leu Leu Pro Thr Thr Pro Phe Leu Leu 
            20                  25                  30          

Leu Ser Ile Ala Cys Phe Ser Arg Ser Ser Lys Arg Phe Glu Asp Trp 
        35                  40                  45              


Leu Tyr His Thr Lys Leu Tyr Gln Ala Tyr Val Ala Asp Phe Arg Glu 
    50                  55                  60                  

Thr Lys Ser Ile Ala Arg Glu Arg Lys Lys Lys Ile Ile Val Ser Ile 
65                  70                  75                  80  

Tyr Val Leu Met Gly Ile Ser Ile Tyr Phe Ala Pro Leu Leu Pro Val 
                85                  90                  95      

Lys Ile Gly Leu Gly Ala Leu Thr Ile Phe Ile Thr Tyr Tyr Leu Phe 
            100                 105                 110         

Lys Val Ile Pro Asp Lys Glu 
        115                 

<210>   2539
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2539
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accttctaaa   180
attccttatc ttgaaacgac tggtatgcct actagaattc tccttagaaa gcgtcgattc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ctatcgtcaa gaagaatcac   300
caaatccctc gtatcatcaa ccaaaaaatt gctcaaaagt taattgaaaa gatttctatg   360
actgatattg cccatcagct ttccatctca acttcaactg ttattcgtaa gctcaatgac   420
tttcacttta aacatgattt ttcttgtctt cctgagatta tgtcttggga tgagtatgct   480
tttacaaagg gaaagatgag cttcattgcg caagatttta acaatctcaa tatcatcact   540
gttcttgagg gaagaacaca agctatcatt cgaaatcact ttcttaaata tgatagagcc   600
gtccgatgtc gcgtcaaaat tattactatg gatatgttta gtccttacta tgacttagct   660
agacaacttt tcccatgtgc taaaatcgtg ttggatcgct ttcacattgt acaacatctt   720
agccgtgcta tgagtcgtgt gcgtgttcaa atcatgaatc aattggatcg aaagtctcat   780
gaatacaagg ctatcaagcg ctactggaag ctcatacaac aggatagtcg taaactcagc   840
gataaacatt tttatcgccc tacttttcgt atgcatttaa ccaataaaga gattttaaac   900
aagcttttga gctattcaca agacttgaaa catcactatc agctctatca actcttgctg   960
tttcactttc agaataagga accggagaaa tttttcggac tcattgagga caatctaaag   1020
caggttcatc ctctttttca gactgtcttt aaaacctttc taaaggacaa agagaaaatc   1080
gtcaacgccc ttcaactaca ctattctaac gccaaattgg aagcgaccaa taatctcatc   1140
aaacttatca agcgcaatgc ctttggtttt cggaactttg aaaacttcaa aaaacggatt   1200
tttatcgctc tgaatatcaa aaaagaaagg acaaaatttg tcctttctcg agct         1254

<210>   2540
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   IS1167, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903763 (0.E+01)

<400>   2540
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ser 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Lys 
    130                 135                 140                 

His Asp Phe Ser Cys Leu Pro Glu Ile Met Ser Trp Asp Glu Tyr Ala 
145                 150                 155                 160 

Phe Thr Lys Gly Lys Met Ser Phe Ile Ala Gln Asp Phe Asn Asn Leu 
                165                 170                 175     

Asn Ile Ile Thr Val Leu Glu Gly Arg Thr Gln Ala Ile Ile Arg Asn 
            180                 185                 190         

His Phe Leu Lys Tyr Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile 
        195                 200                 205             

Thr Met Asp Met Phe Ser Pro Tyr Tyr Asp Leu Ala Arg Gln Leu Phe 
    210                 215                 220                 

Pro Cys Ala Lys Ile Val Leu Asp Arg Phe His Ile Val Gln His Leu 
225                 230                 235                 240 

Ser Arg Ala Met Ser Arg Val Arg Val Gln Ile Met Asn Gln Leu Asp 
                245                 250                 255     

Arg Lys Ser His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile 
            260                 265                 270         

Gln Gln Asp Ser Arg Lys Leu Ser Asp Lys His Phe Tyr Arg Pro Thr 
        275                 280                 285             

Phe Arg Met His Leu Thr Asn Lys Glu Ile Leu Asn Lys Leu Leu Ser 
    290                 295                 300                 

Tyr Ser Gln Asp Leu Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu 
305                 310                 315                 320 

Phe His Phe Gln Asn Lys Glu Pro Glu Lys Phe Phe Gly Leu Ile Glu 
                325                 330                 335     

Asp Asn Leu Lys Gln Val His Pro Leu Phe Gln Thr Val Phe Lys Thr 
            340                 345                 350         

Phe Leu Lys Asp Lys Glu Lys Ile Val Asn Ala Leu Gln Leu His Tyr 
        355                 360                 365             

Ser Asn Ala Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys 
    370                 375                 380                 

Arg Asn Ala Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile 
385                 390                 395                 400 

Phe Ile Ala Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser 
                405                 410                 415     

Arg Ala 
        

<210>   2541
<211>   2115
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2541
ttgaaaaggt gtgatactgt ggctacggca acaaaaaaga aaaaatcaac agttaaaaaa   60
aatctagtca tcgtggagtc gcctgctaag gccaagacga ttgaaaaata tctaggcaga   120
aactacaagg ttttagccag tgtcgggcat atccgtgatt tgaagaaatc cagtatgtcc   180
gtcgatattg aaaataatta tgaaccgcaa tatattaata tccgaggaaa aggccctctt   240
atcaatgact tgaaaaaaga agctaaaaaa gctaataaag tttttctcgc gagtgacccg   300
gaccgtgaag gagaagcgat ttcttggcat ttggcccata ttctcaactt ggatgaaaat   360
gatgccaacc gtgtggtctt caatgaaatc accaaggatg cagtcaaaaa tgcttttaaa   420
gaacctcgta agatcgatat ggacttggtc gatgcccaac aagctcgtcg gatcttggat   480
cgcttggtag ggtattcgat ttcgcctatt ttgtggaaga aggtcaagaa gggcttgtca   540
gcaggtcgcg ttcagtccat tgcccttaaa ctcatcattg accgtgaaaa tgaaatcaat   600
gccttccagc cagaagaata ctggacagtt gatgctgtct ttaaaaaggg aaccaaacaa   660
tttcatgctt ccttctatgg agtagatggt aaaaagatga aactgaccag caataacgaa   720
gtcaaggaag tcttgtctcg tctgacgagt aaagactttt cagtagatca ggtggataag   780
aaagagcgca agcgcaatgc tcctttaccc tataccactt catctatgca gatggatgct   840
gccaataaaa tcaatttccg tactcgaaaa accatgatgg ttgcccaaca gctctatgaa   900
ggaattaata tcggttctgg tgttcaaggt ttgattacct atatgcgtac cgattcgact   960
cgtatcagtc ctgtagcgca aaatgaggcg gcaagcttca ttacggatcg ttttggtagc   1020
aagtattcta agcacggtag caaggtcaaa aacgcatcag gtgctcagga tgcccatgag   1080
gctattcgtc cgtcaagtgt ctttaataca ccagaaagca tcgctaagta tctggacaag   1140
gatcagctta agctatatac ccttatctgg aatcgttttg tggctagcca gatgacagcg   1200
gccgtttttg ataccatggc tgttaaattg tctcaaaaag gggttcaatt tgctgccaat   1260
ggtagtcagg ttaagtttga tggttatctt gccatttata atgattctga caagaataag   1320
atgttaccgg acatggttgt tggagatgtg gtcaaacagg tcaatagcaa accagagcaa   1380
catttcaccc aaccgcctgc ccgttattct gaagcaacac tgattaaaac cttagaggaa   1440
aatggggttg gacgtccatc aacctacgcg ccaaccattg aaaccattca gaaacgttat   1500
tatgttcgcc tggcagccaa acgttttgaa ccgacagagt tgggagaaat tgtcaataag   1560
ctcatcgttg aatatttccc agatatcgta aacgtgacct tcacagctga aatggaaggt   1620

aaactggatg atgtcgaagt tggaaaagag cagtggcgac gggtcattga tgccttttac   1680
aaaccattct ctaaagaagt tgccaaggct gaagaagaaa tggaaaaaat ccagattaag   1740
gatgaaccag ctggatttga ctgtgaagtg tgtggcagtc caatggtcat taaacttggt   1800
cgttttggta aattctacgc ttgtagcaat ttcccagatt gccgtcatac ccaagcaatc   1860
gtgaaagaga ttggtgttga gtgtccaagc tgtcatcagg gacaaattat tgagcgaaaa   1920
accaagcgta atcgcctatt ctatggttgc aatcgctatc cagaatgtga atttacctct   1980
tgggacaagc ctgttggtcg tgactgtcca aaatgtggca acttcctcat ggagaaaaaa   2040
gtccgtggtg gtggcaagca ggttgtttgt agcaaaggcg actacgagga agaaaagatg   2100
gctctttgtc aactg                                                    2115

<210>   2542
<211>   705
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA topoisomerase I (topA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903580 (8.E-38)

<400>   2542
Met Lys Arg Cys Asp Thr Val Ala Thr Ala Thr Lys Lys Lys Lys Ser 
1               5                   10                  15      

Thr Val Lys Lys Asn Leu Val Ile Val Glu Ser Pro Ala Lys Ala Lys 
            20                  25                  30          

Thr Ile Glu Lys Tyr Leu Gly Arg Asn Tyr Lys Val Leu Ala Ser Val 
        35                  40                  45              

Gly His Ile Arg Asp Leu Lys Lys Ser Ser Met Ser Val Asp Ile Glu 
    50                  55                  60                  

Asn Asn Tyr Glu Pro Gln Tyr Ile Asn Ile Arg Gly Lys Gly Pro Leu 
65                  70                  75                  80  

Ile Asn Asp Leu Lys Lys Glu Ala Lys Lys Ala Asn Lys Val Phe Leu 
                85                  90                  95      

Ala Ser Asp Pro Asp Arg Glu Gly Glu Ala Ile Ser Trp His Leu Ala 
            100                 105                 110         

His Ile Leu Asn Leu Asp Glu Asn Asp Ala Asn Arg Val Val Phe Asn 
        115                 120                 125             

Glu Ile Thr Lys Asp Ala Val Lys Asn Ala Phe Lys Glu Pro Arg Lys 
    130                 135                 140                 

Ile Asp Met Asp Leu Val Asp Ala Gln Gln Ala Arg Arg Ile Leu Asp 
145                 150                 155                 160 

Arg Leu Val Gly Tyr Ser Ile Ser Pro Ile Leu Trp Lys Lys Val Lys 
                165                 170                 175     

Lys Gly Leu Ser Ala Gly Arg Val Gln Ser Ile Ala Leu Lys Leu Ile 
            180                 185                 190         

Ile Asp Arg Glu Asn Glu Ile Asn Ala Phe Gln Pro Glu Glu Tyr Trp 
        195                 200                 205             

Thr Val Asp Ala Val Phe Lys Lys Gly Thr Lys Gln Phe His Ala Ser 
    210                 215                 220                 

Phe Tyr Gly Val Asp Gly Lys Lys Met Lys Leu Thr Ser Asn Asn Glu 
225                 230                 235                 240 

Val Lys Glu Val Leu Ser Arg Leu Thr Ser Lys Asp Phe Ser Val Asp 
                245                 250                 255     

Gln Val Asp Lys Lys Glu Arg Lys Arg Asn Ala Pro Leu Pro Tyr Thr 
            260                 265                 270         

Thr Ser Ser Met Gln Met Asp Ala Ala Asn Lys Ile Asn Phe Arg Thr 
        275                 280                 285             

Arg Lys Thr Met Met Val Ala Gln Gln Leu Tyr Glu Gly Ile Asn Ile 
    290                 295                 300                 

Gly Ser Gly Val Gln Gly Leu Ile Thr Tyr Met Arg Thr Asp Ser Thr 
305                 310                 315                 320 

Arg Ile Ser Pro Val Ala Gln Asn Glu Ala Ala Ser Phe Ile Thr Asp 
                325                 330                 335     

Arg Phe Gly Ser Lys Tyr Ser Lys His Gly Ser Lys Val Lys Asn Ala 
            340                 345                 350         

Ser Gly Ala Gln Asp Ala His Glu Ala Ile Arg Pro Ser Ser Val Phe 
        355                 360                 365             

Asn Thr Pro Glu Ser Ile Ala Lys Tyr Leu Asp Lys Asp Gln Leu Lys 
    370                 375                 380                 

Leu Tyr Thr Leu Ile Trp Asn Arg Phe Val Ala Ser Gln Met Thr Ala 
385                 390                 395                 400 

Ala Val Phe Asp Thr Met Ala Val Lys Leu Ser Gln Lys Gly Val Gln 
                405                 410                 415     

Phe Ala Ala Asn Gly Ser Gln Val Lys Phe Asp Gly Tyr Leu Ala Ile 
            420                 425                 430         

Tyr Asn Asp Ser Asp Lys Asn Lys Met Leu Pro Asp Met Val Val Gly 
        435                 440                 445             

Asp Val Val Lys Gln Val Asn Ser Lys Pro Glu Gln His Phe Thr Gln 
    450                 455                 460                 

Pro Pro Ala Arg Tyr Ser Glu Ala Thr Leu Ile Lys Thr Leu Glu Glu 
465                 470                 475                 480 

Asn Gly Val Gly Arg Pro Ser Thr Tyr Ala Pro Thr Ile Glu Thr Ile 
                485                 490                 495     

Gln Lys Arg Tyr Tyr Val Arg Leu Ala Ala Lys Arg Phe Glu Pro Thr 
            500                 505                 510         

Glu Leu Gly Glu Ile Val Asn Lys Leu Ile Val Glu Tyr Phe Pro Asp 
        515                 520                 525             

Ile Val Asn Val Thr Phe Thr Ala Glu Met Glu Gly Lys Leu Asp Asp 
    530                 535                 540                 

Val Glu Val Gly Lys Glu Gln Trp Arg Arg Val Ile Asp Ala Phe Tyr 
545                 550                 555                 560 

Lys Pro Phe Ser Lys Glu Val Ala Lys Ala Glu Glu Glu Met Glu Lys 
                565                 570                 575     

Ile Gln Ile Lys Asp Glu Pro Ala Gly Phe Asp Cys Glu Val Cys Gly 
            580                 585                 590         

Ser Pro Met Val Ile Lys Leu Gly Arg Phe Gly Lys Phe Tyr Ala Cys 
        595                 600                 605             

Ser Asn Phe Pro Asp Cys Arg His Thr Gln Ala Ile Val Lys Glu Ile 
    610                 615                 620                 

Gly Val Glu Cys Pro Ser Cys His Gln Gly Gln Ile Ile Glu Arg Lys 
625                 630                 635                 640 

Thr Lys Arg Asn Arg Leu Phe Tyr Gly Cys Asn Arg Tyr Pro Glu Cys 
                645                 650                 655     

Glu Phe Thr Ser Trp Asp Lys Pro Val Gly Arg Asp Cys Pro Lys Cys 
            660                 665                 670         

Gly Asn Phe Leu Met Glu Lys Lys Val Arg Gly Gly Gly Lys Gln Val 
        675                 680                 685             

Val Cys Ser Lys Gly Asp Tyr Glu Glu Glu Lys Met Ala Leu Cys Gln 
    690                 695                 700                 

Leu 
705 

<210>   2543
<211>   1041
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2543
gtgacaaata ataaactgta ttcgttgata gaatttagaa ataaaatata tgaagaatta   60
gaactttcca gaagtgattt agcgatttta ctatgtgcca tgcttatcgc ctctatcgga   120
ttaaatatgg attcgactcc cgtgattatt ggagccatgt taatctctcc tttgatgaca   180
cctattctgg gagtggggct ctctctagct atatttgatt ttaaattgtt aagaaaatct   240
tttaaaatat tagctattca aattcttgcc agtctaatag cttcaacact ttatttttat   300

ctttctccca tttcgtatgc tagttcggag attgttgcta gaacctctcc gactatttgg   360
gatgttctca ttgcttttgt aggagggata gcaggtatca ttggtgctag gaaaaaagag   420
accaataata ttgttcctgg tgttgctatt gcaaccgcct tgatgcctcc tctttgtaca   480
gtaggttatg ctattgcttc tgctaatcta aaatttatca taggctcctc ttacctattc   540
ctcatcaatt gtagctttat tgtcattgcg acttatatag gtgttaggtt gatgatggtt   600
aagaaacatt attttaaaga taatgaagaa gactctaaaa tgcgtaggat tttgcttcta   660
gttgctgttt tgctgatgat tccgagtttc atctctgcaa cgactttagt gagagaaacg   720
ttgaaaaaag agtcccttaa gaaatttata tcagagcagt ttcaggggta taatattttg   780
aaaaaaacct attctaaaaa gactcatacc ctaaagctaa ccatttcagg aaattatttg   840
acagaagaag aactcgatat gatttcaagt aagagaggtg actatggttt aagtgatgtt   900
tctgttcaag tttcacaatt gtctgattca gaacaactta gtaaggaaga gctggtggag   960
tatttcttcc agtatatcaa ggataaggaa gcaaaagaaa aggagaaagc caataaattt   1020
gatacagagt ctgaggagca a                                             1041

<210>   2544
<211>   347
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15903185 (0.E+01)

<400>   2544
Met Thr Asn Asn Lys Leu Tyr Ser Leu Ile Glu Phe Arg Asn Lys Ile 
1               5                   10                  15      

Tyr Glu Glu Leu Glu Leu Ser Arg Ser Asp Leu Ala Ile Leu Leu Cys 
            20                  25                  30          

Ala Met Leu Ile Ala Ser Ile Gly Leu Asn Met Asp Ser Thr Pro Val 
        35                  40                  45              

Ile Ile Gly Ala Met Leu Ile Ser Pro Leu Met Thr Pro Ile Leu Gly 
    50                  55                  60                  

Val Gly Leu Ser Leu Ala Ile Phe Asp Phe Lys Leu Leu Arg Lys Ser 
65                  70                  75                  80  

Phe Lys Ile Leu Ala Ile Gln Ile Leu Ala Ser Leu Ile Ala Ser Thr 
                85                  90                  95      

Leu Tyr Phe Tyr Leu Ser Pro Ile Ser Tyr Ala Ser Ser Glu Ile Val 
            100                 105                 110         

Ala Arg Thr Ser Pro Thr Ile Trp Asp Val Leu Ile Ala Phe Val Gly 
        115                 120                 125             

Gly Ile Ala Gly Ile Ile Gly Ala Arg Lys Lys Glu Thr Asn Asn Ile 
    130                 135                 140                 

Val Pro Gly Val Ala Ile Ala Thr Ala Leu Met Pro Pro Leu Cys Thr 
145                 150                 155                 160 

Val Gly Tyr Ala Ile Ala Ser Ala Asn Leu Lys Phe Ile Ile Gly Ser 
                165                 170                 175     


Ser Tyr Leu Phe Leu Ile Asn Cys Ser Phe Ile Val Ile Ala Thr Tyr 
            180                 185                 190         

Ile Gly Val Arg Leu Met Met Val Lys Lys His Tyr Phe Lys Asp Asn 
        195                 200                 205             

Glu Glu Asp Ser Lys Met Arg Arg Ile Leu Leu Leu Val Ala Val Leu 
    210                 215                 220                 

Leu Met Ile Pro Ser Phe Ile Ser Ala Thr Thr Leu Val Arg Glu Thr 
225                 230                 235                 240 

Leu Lys Lys Glu Ser Leu Lys Lys Phe Ile Ser Glu Gln Phe Gln Gly 
                245                 250                 255     

Tyr Asn Ile Leu Lys Lys Thr Tyr Ser Lys Lys Thr His Thr Leu Lys 
            260                 265                 270         

Leu Thr Ile Ser Gly Asn Tyr Leu Thr Glu Glu Glu Leu Asp Met Ile 
        275                 280                 285             

Ser Ser Lys Arg Gly Asp Tyr Gly Leu Ser Asp Val Ser Val Gln Val 
    290                 295                 300                 

Ser Gln Leu Ser Asp Ser Glu Gln Leu Ser Lys Glu Glu Leu Val Glu 
305                 310                 315                 320 

Tyr Phe Phe Gln Tyr Ile Lys Asp Lys Glu Ala Lys Glu Lys Glu Lys 
                325                 330                 335     

Ala Asn Lys Phe Asp Thr Glu Ser Glu Glu Gln 
            340                 345         

<210>   2545
<211>   174
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2545
atgatacttt tcgaaaatct cttcaaatac gtcagctcag ctttgccttg ctgtgttttg   60
agcaagctac ggttagcttc cgagtttgat tttcatttac tagaaatgaa actgatgaga   120
gatatcagta gacatttgag tcaggatatt atggaaaatg ataaaaagag ctcg         174

<210>   2546
<211>   58
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   2546
Met Ile Leu Phe Glu Asn Leu Phe Lys Tyr Val Ser Ser Ala Leu Pro 
1               5                   10                  15      

Cys Cys Val Leu Ser Lys Leu Arg Leu Ala Ser Glu Phe Asp Phe His 
            20                  25                  30          

Leu Leu Glu Met Lys Leu Met Arg Asp Ile Ser Arg His Leu Ser Gln 
        35                  40                  45              

Asp Ile Met Glu Asn Asp Lys Lys Ser Ser 
    50                  55              

<210>   2547
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2547
ttgaagagat tttcgaaaag tatcatcatc tatttcagac cattttttat aataaccatt   60
ttatttttat ttgtcaaggt ctttgaattc tttcttaaac aagccttg                108

<210>   2548
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   2548
Met Lys Arg Phe Ser Lys Ser Ile Ile Ile Tyr Phe Arg Pro Phe Phe 
1               5                   10                  15      

Ile Ile Thr Ile Leu Phe Leu Phe Val Lys Val Phe Glu Phe Phe Leu 
            20                  25                  30          

Lys Gln Ala Leu 
        35      

<210>   2549
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2549
ttgtcagtaa ggaaaaataa attcttcaaa agtagagatt acaaggcttg tttaagaaag   60
aattcaaaga ccttgacaaa taaaaataaa atggttatta taaaaaatgg tctgaaa      117

<210>   2550
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903186 (1.E-15)

<400>   2550
Met Ser Val Arg Lys Asn Lys Phe Phe Lys Ser Arg Asp Tyr Lys Ala 
1               5                   10                  15      

Cys Leu Arg Lys Asn Ser Lys Thr Leu Thr Asn Lys Asn Lys Met Val 
            20                  25                  30          

Ile Ile Lys Asn Gly Leu Lys 
        35                  

<210>   2551
<211>   858
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2551
atggagttat ttatgaaaat cacaaactat gaaatctata agttaaaaaa atcaggtttg   60
accaatcaac agattttgaa agtgctagaa tacggtgaaa atgttgatca ggagcttttg   120
ttgggtgata ttgcagatat ctcaggttgc cgtaatccag ccgtttttat ggaacgttat   180
tttcagatag acgatgcgca tttgtcgaaa gagtttcaaa aatttccatc tttctctatt   240
ttagatgact gttatccttg ggatttgagt gaaatatatg atgcgcctgt acttttattt   300
tacaagggaa atcttgacct cctgaaattc ccgaaggtag cggtcgtggg cagtcgtgct   360
tgtagcaaac agggagctaa gtcagttgaa aaagtcattc aaggcttgga aaatgaactg   420
gttattgtca gtggtctggc caagggcatt gacacagcag ctcatatggc agctcttcag   480
aatggcggaa aaaccattgc agtgattgga acaggactgg atgtgtttta tcctaaagcc   540
aataaacgct tgcaagacta catcggcaat gaccatctgg ttctaagtga atatggacct   600
ggtgaacaac ctctgaaatt tcattttcct gcccgtaatc gcatcattgc tggactttgt   660
cgtggtgtga ttgtagcaga ggctaagatg cgttcaggta gtctcattac gtgtgagcga   720
gcaatggaag aaggacgcga tgtctttgct attcctggta gcattttaga tggactatca   780
gacggttgcc atcatttgat tcaagaagga gcaaaattgg tcaccagtgg gcaagatgtt   840
cttgcggaat ttgaattt                                                 858

<210>   2552
<211>   286
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA processing protein DprA, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903187 (e-165)

<400>   2552
Met Glu Leu Phe Met Lys Ile Thr Asn Tyr Glu Ile Tyr Lys Leu Lys 
1               5                   10                  15      

Lys Ser Gly Leu Thr Asn Gln Gln Ile Leu Lys Val Leu Glu Tyr Gly 
            20                  25                  30          

Glu Asn Val Asp Gln Glu Leu Leu Leu Gly Asp Ile Ala Asp Ile Ser 
        35                  40                  45              

Gly Cys Arg Asn Pro Ala Val Phe Met Glu Arg Tyr Phe Gln Ile Asp 
    50                  55                  60                  

Asp Ala His Leu Ser Lys Glu Phe Gln Lys Phe Pro Ser Phe Ser Ile 
65                  70                  75                  80  

Leu Asp Asp Cys Tyr Pro Trp Asp Leu Ser Glu Ile Tyr Asp Ala Pro 
                85                  90                  95      

Val Leu Leu Phe Tyr Lys Gly Asn Leu Asp Leu Leu Lys Phe Pro Lys 
            100                 105                 110         

Val Ala Val Val Gly Ser Arg Ala Cys Ser Lys Gln Gly Ala Lys Ser 
        115                 120                 125             

Val Glu Lys Val Ile Gln Gly Leu Glu Asn Glu Leu Val Ile Val Ser 
    130                 135                 140                 

Gly Leu Ala Lys Gly Ile Asp Thr Ala Ala His Met Ala Ala Leu Gln 
145                 150                 155                 160 

Asn Gly Gly Lys Thr Ile Ala Val Ile Gly Thr Gly Leu Asp Val Phe 
                165                 170                 175     

Tyr Pro Lys Ala Asn Lys Arg Leu Gln Asp Tyr Ile Gly Asn Asp His 
            180                 185                 190         

Leu Val Leu Ser Glu Tyr Gly Pro Gly Glu Gln Pro Leu Lys Phe His 
        195                 200                 205             

Phe Pro Ala Arg Asn Arg Ile Ile Ala Gly Leu Cys Arg Gly Val Ile 
    210                 215                 220                 

Val Ala Glu Ala Lys Met Arg Ser Gly Ser Leu Ile Thr Cys Glu Arg 
225                 230                 235                 240 

Ala Met Glu Glu Gly Arg Asp Val Phe Ala Ile Pro Gly Ser Ile Leu 
                245                 250                 255     

Asp Gly Leu Ser Asp Gly Cys His His Leu Ile Gln Glu Gly Ala Lys 
            260                 265                 270         

Leu Val Thr Ser Gly Gln Asp Val Leu Ala Glu Phe Glu Phe 
        275                 280                 285     

<210>   2553
<211>   687
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2553
gtgaaagcca ttatcttagc agcgggattg ggaactcgct tgcgtcctat gactgaaaat   60
acccctaaag ccttggttca ggttaatcaa aaacctttga ttgagtacca aattgagttt   120
ctcaaagaaa aaggaatcaa tgacatcatc atcattgttg gttatcttaa agaacaattc   180
gattacttga aagagaaata cggtgttcgt ctcgttttca atgataaata cgctgactac   240
aataactttt actctctcta tcttgtaaaa gaagaattgg ccaacagcta tgttattgat   300
gctgacaatt atctctttaa aaatatgttc cgcaatgatt tgacacgttc gacttatttt   360
agtgtttatc gtgaagattg taccaacgaa tggttcttgg tttatggaga tgactacaag   420
gttcaagaca ttattgttga tagcaaggca ggtcgcatcc ttagtggtgt atccttctgg   480
gatgctccaa ctgcagaaaa gattgtcagc tttatcgaca aggcttatgt aagtggtgaa   540
tttgttgatc tctattggga caatatggtt aaggataata tcaaagagct agatgtctat   600
gttgaagaat tagaaggcaa tagcatttat gagatcgata gtgtccaaga ctatcgtaaa   660
ttagaagaaa ttcttaaaaa cgaaaat                                       687

<210>   2554
<211>   229
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   licC protein (licC)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903188 (e-131)

<400>   2554
Met Lys Ala Ile Ile Leu Ala Ala Gly Leu Gly Thr Arg Leu Arg Pro 
1               5                   10                  15      

Met Thr Glu Asn Thr Pro Lys Ala Leu Val Gln Val Asn Gln Lys Pro 
            20                  25                  30          

Leu Ile Glu Tyr Gln Ile Glu Phe Leu Lys Glu Lys Gly Ile Asn Asp 
        35                  40                  45              

Ile Ile Ile Ile Val Gly Tyr Leu Lys Glu Gln Phe Asp Tyr Leu Lys 
    50                  55                  60                  

Glu Lys Tyr Gly Val Arg Leu Val Phe Asn Asp Lys Tyr Ala Asp Tyr 
65                  70                  75                  80  

Asn Asn Phe Tyr Ser Leu Tyr Leu Val Lys Glu Glu Leu Ala Asn Ser 
                85                  90                  95      

Tyr Val Ile Asp Ala Asp Asn Tyr Leu Phe Lys Asn Met Phe Arg Asn 
            100                 105                 110         

Asp Leu Thr Arg Ser Thr Tyr Phe Ser Val Tyr Arg Glu Asp Cys Thr 
        115                 120                 125             

Asn Glu Trp Phe Leu Val Tyr Gly Asp Asp Tyr Lys Val Gln Asp Ile 
    130                 135                 140                 

Ile Val Asp Ser Lys Ala Gly Arg Ile Leu Ser Gly Val Ser Phe Trp 
145                 150                 155                 160 

Asp Ala Pro Thr Ala Glu Lys Ile Val Ser Phe Ile Asp Lys Ala Tyr 
                165                 170                 175     

Val Ser Gly Glu Phe Val Asp Leu Tyr Trp Asp Asn Met Val Lys Asp 
            180                 185                 190         

Asn Ile Lys Glu Leu Asp Val Tyr Val Glu Glu Leu Glu Gly Asn Ser 
        195                 200                 205             

Ile Tyr Glu Ile Asp Ser Val Gln Asp Tyr Arg Lys Leu Glu Glu Ile 
    210                 215                 220                 

Leu Lys Asn Glu Asn 
225                 

<210>   2555
<211>   888
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2555
atggaggttc agatgaaaag taaaaacgga gttccttttg gccttctctc aggtattttc   60
tggggcttgg gtctaacggt tagtgcttat atcttttcga tttttacaga tttgtcaccc   120
tttgtggtgg ctgcaactca tgattttttg agcatcttta tcttactagc ttttctcttg   180
gtaaaagaag ggaaagttcg cctctcaatt ttcttaaata ttcgcaatgt cagtgttatc   240
atcggagcct tgctagcagg ccctatcggt atgcaggcca atctttatgc agttaagtat   300
atcggaagtt ctttagcttc atctgtatcg gctatttacc ctgcgatttc agttctattg   360
gctttcttct ttttgaagca caagatttcg aaaaatactg tatttgggat tgtcttgatt   420
attggaggga ttattgctca gacctataag gttgaacagg ttaattcttt ctacattggg   480
attctttgtg ctttggtttg tgctattgca tggggaagtg agagtgttct tagctctttt   540
gccatggaaa gtgaattgag tgaaatcgaa gccctcttaa tccgtcaagt aacttcgttc   600
ttgtcctatc ttgtgattgt gctcttctct catcagtcat ttactgcagt agccaatgga   660
caattgctag gtctcatgat tgtttttgca gcctttgata tgatttccta cttggcttat   720
tatatcgcta tcaatcgctt gcaaccagcc aaggctacag gcttgaacgt gagctatgta   780
gtatggacgg tcttgtttgc agttgttttc ttgggtgcac cgctagatat gctgaccatt   840
atgacgtcac ttgtcgtcat tgctggagtt tatattatta ttaaagaa                888

<210>   2556
<211>   296
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   licB protein (licB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903189 (e-159)

<400>   2556
Met Glu Val Gln Met Lys Ser Lys Asn Gly Val Pro Phe Gly Leu Leu 
1               5                   10                  15      

Ser Gly Ile Phe Trp Gly Leu Gly Leu Thr Val Ser Ala Tyr Ile Phe 
            20                  25                  30          

Ser Ile Phe Thr Asp Leu Ser Pro Phe Val Val Ala Ala Thr His Asp 
        35                  40                  45              

Phe Leu Ser Ile Phe Ile Leu Leu Ala Phe Leu Leu Val Lys Glu Gly 
    50                  55                  60                  

Lys Val Arg Leu Ser Ile Phe Leu Asn Ile Arg Asn Val Ser Val Ile 
65                  70                  75                  80  

Ile Gly Ala Leu Leu Ala Gly Pro Ile Gly Met Gln Ala Asn Leu Tyr 
                85                  90                  95      

Ala Val Lys Tyr Ile Gly Ser Ser Leu Ala Ser Ser Val Ser Ala Ile 
            100                 105                 110         

Tyr Pro Ala Ile Ser Val Leu Leu Ala Phe Phe Phe Leu Lys His Lys 
        115                 120                 125             

Ile Ser Lys Asn Thr Val Phe Gly Ile Val Leu Ile Ile Gly Gly Ile 
    130                 135                 140                 

Ile Ala Gln Thr Tyr Lys Val Glu Gln Val Asn Ser Phe Tyr Ile Gly 
145                 150                 155                 160 

Ile Leu Cys Ala Leu Val Cys Ala Ile Ala Trp Gly Ser Glu Ser Val 
                165                 170                 175     

Leu Ser Ser Phe Ala Met Glu Ser Glu Leu Ser Glu Ile Glu Ala Leu 
            180                 185                 190         

Leu Ile Arg Gln Val Thr Ser Phe Leu Ser Tyr Leu Val Ile Val Leu 
        195                 200                 205             

Phe Ser His Gln Ser Phe Thr Ala Val Ala Asn Gly Gln Leu Leu Gly 
    210                 215                 220                 

Leu Met Ile Val Phe Ala Ala Phe Asp Met Ile Ser Tyr Leu Ala Tyr 
225                 230                 235                 240 

Tyr Ile Ala Ile Asn Arg Leu Gln Pro Ala Lys Ala Thr Gly Leu Asn 
                245                 250                 255     

Val Ser Tyr Val Val Trp Thr Val Leu Phe Ala Val Val Phe Leu Gly 
            260                 265                 270         

Ala Pro Leu Asp Met Leu Thr Ile Met Thr Ser Leu Val Val Ile Ala 
        275                 280                 285             

Gly Val Tyr Ile Ile Ile Lys Glu 
    290                 295     

<210>   2557
<211>   867
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2557
gtggagaaaa tcattaaaga aaaaatttct tccttactta gtcaagaaga ggaagtcctc   60
agtgttgaac aactgggtgg aatgaccaat caaaactatt tggccaaaac aacaaataag   120
caatacattg ttaaattctt tggtaaaggg acagaaaagc ttatcaatcg acaagatgaa   180
aagtacaatc ttgaactact aaaggattta ggcttagatg taaaaaatta tctttttgat   240
attgaagctg gtatcaaagt aaatgagtat atcgaatctg cgattacgct tgattcaacg   300
tcaatcaaga ccaagttcga caaaattact ccaatattac aaactattca tacgtctgct   360
aaggaattaa gaggagaatt tgctcctttt gaagaaatca aaaaatacga atccttgatt   420
gaagaacaaa ttccttatgc caactatgaa tctgttagaa atgcagtctt ctccttagag   480
aaaagactgg ctgacttagg tgttgacaga aaatcttgtc atatcgattt ggtgcctgaa   540
aactttatcg aatcacctca aggacgactt tatttgattg actgggaata ttcatcaatg   600
aatgatccaa tgtgggattt ggctgccctc tttttagagt ctgaattcac ttcccaagag   660
gaagaaactt tcttatctca ctatgagagt gaccaaacac cggtttctca tgaaaagatt   720
gctatttata aaattttaca agatactatt tggagtctat ggactgtcta taaggaagag   780
caaggtgaag attttggtga ctatggtgtg aatcgttacc aaagagctat taaaggtttg   840

gcttcttatg gaggttcaga tgaaaag                                       867

<210>   2558
<211>   289
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline kinase (pck)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903190 (e-151)

<400>   2558
Met Glu Lys Ile Ile Lys Glu Lys Ile Ser Ser Leu Leu Ser Gln Glu 
1               5                   10                  15      

Glu Glu Val Leu Ser Val Glu Gln Leu Gly Gly Met Thr Asn Gln Asn 
            20                  25                  30          

Tyr Leu Ala Lys Thr Thr Asn Lys Gln Tyr Ile Val Lys Phe Phe Gly 
        35                  40                  45              

Lys Gly Thr Glu Lys Leu Ile Asn Arg Gln Asp Glu Lys Tyr Asn Leu 
    50                  55                  60                  

Glu Leu Leu Lys Asp Leu Gly Leu Asp Val Lys Asn Tyr Leu Phe Asp 
65                  70                  75                  80  

Ile Glu Ala Gly Ile Lys Val Asn Glu Tyr Ile Glu Ser Ala Ile Thr 
                85                  90                  95      

Leu Asp Ser Thr Ser Ile Lys Thr Lys Phe Asp Lys Ile Thr Pro Ile 
            100                 105                 110         

Leu Gln Thr Ile His Thr Ser Ala Lys Glu Leu Arg Gly Glu Phe Ala 
        115                 120                 125             

Pro Phe Glu Glu Ile Lys Lys Tyr Glu Ser Leu Ile Glu Glu Gln Ile 
    130                 135                 140                 

Pro Tyr Ala Asn Tyr Glu Ser Val Arg Asn Ala Val Phe Ser Leu Glu 
145                 150                 155                 160 

Lys Arg Leu Ala Asp Leu Gly Val Asp Arg Lys Ser Cys His Ile Asp 
                165                 170                 175     

Leu Val Pro Glu Asn Phe Ile Glu Ser Pro Gln Gly Arg Leu Tyr Leu 
            180                 185                 190         

Ile Asp Trp Glu Tyr Ser Ser Met Asn Asp Pro Met Trp Asp Leu Ala 
        195                 200                 205             

Ala Leu Phe Leu Glu Ser Glu Phe Thr Ser Gln Glu Glu Glu Thr Phe 
    210                 215                 220                 

Leu Ser His Tyr Glu Ser Asp Gln Thr Pro Val Ser His Glu Lys Ile 
225                 230                 235                 240 

Ala Ile Tyr Lys Ile Leu Gln Asp Thr Ile Trp Ser Leu Trp Thr Val 
                245                 250                 255     

Tyr Lys Glu Glu Gln Gly Glu Asp Phe Gly Asp Tyr Gly Val Asn Arg 
            260                 265                 270         

Tyr Gln Arg Ala Ile Lys Gly Leu Ala Ser Tyr Gly Gly Ser Asp Glu 
        275                 280                 285             

Lys 
    

<210>   2559
<211>   1038
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2559
ttgagaaaga ctagtaaaat gattaatcaa atttatcaac taactaagcc taagtttatc   60
aatgtcaaat atcaggaaga ggctattgac caagagaatc atatccttat ccgtcccaac   120
tacatggctg tctgtcatgc ggatcagcgt tactatcagg gaaaacgtga tcccaagatt   180
ttgaataaaa agcttccaat ggcaatgatt cacgagtcat gtggaaccgt catttctgac   240
ccgaccggaa cctacgaggt tggtcaaaaa gttgtcatga ttcccaatca gtctcctatg   300
cagagtgatg aagaattcta tgaaaactac atgacaggga cccatttctt gtctagtgga   360
tttgatggct ttatgagaga gtttgtttct ctccctaaag atcgtgtggt ggcttatgat   420
gctattgaag atacggttgc agccattaca gagtttgtca gtgtgggcat gcacgctatg   480
aatcgtctat tgactcttgc tcatagcaag cgggagcgga tcgccgttat tggagatgga   540
agtttagctt ttgtggttgc caatattatc aactatactt tgccagaagc agagattgtg   600
gttattggtc gtcattggga aaagttggaa ctcttctcat ttgccaaaga atgctatatt   660
acggataata ttcctgaaga tttggccttt gaccatgctt ttgaatgttg tggtggtgat   720
ggtactggac cagctattaa tgacttgatt cgctacattc gtcctcaggg aacgattctc   780
atgatgggag ttagcgaata taaagtcaat ctcaatactc gcgatgcctt agaaaagggc   840
ttgattttgg ttgggtcatc tcgttctggt cgcattgatt ttgaaaatgc tatccaaatg   900
atggaagtca agaaatttgc caatcgtctt aaaaatatcc tttatctaga agaacctgta   960
agagaaatta aagatattca tcgtgtcttt gcaaccgatt taaacacagc ctttaaaaca   1020
gtgtttaagt gggaagta                                                 1038

<210>   2560
<211>   346
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alcohol dehydrogenase, zinc-containing
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903191 (0.E+01)

<400>   2560
Met Arg Lys Thr Ser Lys Met Ile Asn Gln Ile Tyr Gln Leu Thr Lys 
1               5                   10                  15      

Pro Lys Phe Ile Asn Val Lys Tyr Gln Glu Glu Ala Ile Asp Gln Glu 
            20                  25                  30          

Asn His Ile Leu Ile Arg Pro Asn Tyr Met Ala Val Cys His Ala Asp 
        35                  40                  45              

Gln Arg Tyr Tyr Gln Gly Lys Arg Asp Pro Lys Ile Leu Asn Lys Lys 
    50                  55                  60                  

Leu Pro Met Ala Met Ile His Glu Ser Cys Gly Thr Val Ile Ser Asp 
65                  70                  75                  80  

Pro Thr Gly Thr Tyr Glu Val Gly Gln Lys Val Val Met Ile Pro Asn 
                85                  90                  95      

Gln Ser Pro Met Gln Ser Asp Glu Glu Phe Tyr Glu Asn Tyr Met Thr 
            100                 105                 110         

Gly Thr His Phe Leu Ser Ser Gly Phe Asp Gly Phe Met Arg Glu Phe 
        115                 120                 125             

Val Ser Leu Pro Lys Asp Arg Val Val Ala Tyr Asp Ala Ile Glu Asp 
    130                 135                 140                 

Thr Val Ala Ala Ile Thr Glu Phe Val Ser Val Gly Met His Ala Met 
145                 150                 155                 160 

Asn Arg Leu Leu Thr Leu Ala His Ser Lys Arg Glu Arg Ile Ala Val 
                165                 170                 175     

Ile Gly Asp Gly Ser Leu Ala Phe Val Val Ala Asn Ile Ile Asn Tyr 
            180                 185                 190         

Thr Leu Pro Glu Ala Glu Ile Val Val Ile Gly Arg His Trp Glu Lys 
        195                 200                 205             

Leu Glu Leu Phe Ser Phe Ala Lys Glu Cys Tyr Ile Thr Asp Asn Ile 
    210                 215                 220                 

Pro Glu Asp Leu Ala Phe Asp His Ala Phe Glu Cys Cys Gly Gly Asp 
225                 230                 235                 240 

Gly Thr Gly Pro Ala Ile Asn Asp Leu Ile Arg Tyr Ile Arg Pro Gln 
                245                 250                 255     

Gly Thr Ile Leu Met Met Gly Val Ser Glu Tyr Lys Val Asn Leu Asn 
            260                 265                 270         

Thr Arg Asp Ala Leu Glu Lys Gly Leu Ile Leu Val Gly Ser Ser Arg 
        275                 280                 285             

Ser Gly Arg Ile Asp Phe Glu Asn Ala Ile Gln Met Met Glu Val Lys 
    290                 295                 300                 

Lys Phe Ala Asn Arg Leu Lys Asn Ile Leu Tyr Leu Glu Glu Pro Val 
305                 310                 315                 320 

Arg Glu Ile Lys Asp Ile His Arg Val Phe Ala Thr Asp Leu Asn Thr 
                325                 330                 335     

Ala Phe Lys Thr Val Phe Lys Trp Glu Val 
            340                 345     

<210>   2561
<211>   705
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2561
atgatttatg caggaattct tgccggtgga actggcacac gcatggggat cagtaacttg   60
ccaaaacaat ttttagagct aggtgatcga cctattttga ttcatacaat tgaaaaattt   120
gtcttggagc caagtattga aaaaattgta gttggtgttc atggagactg ggtttctcat   180
gcagaagatc ttgtagataa atatcttcct ctttataagg aacgtatcat cattacaaag   240
ggtggtgctg accgcaatac aagtattaag aacatcattg aagccattga tgcttatcgt   300
ccgcttactc cagaggatat cgttgttacc cacgattctg ttcgtccatt tattacactt   360
cgcatgattc aggacaatat ccaacttgcc caaaatcatg acgcagtgga cacagtggta   420
gaagcggttg atactatcgt tgaaagtacc aatggtcaat ttattacaga tattccaaat   480
cgtgctcacc tttatcaagg acaaacacct caaacattcc gttgcaagga cttcatggac   540
ctttatggat ctctttctga tgaagagaag gaaatcttga cagatgcatg taaaatcttt   600
gtgatcaaag gaaaagatgt ggctttggcc aaaggtgaat actcaaatct gaagattaca   660
accgtaacag atttgaagat tgcaaaaagt atgattgaga aagac                   705

<210>   2562
<211>   235
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cytidine diphosphocholine pyrophosphorylase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903192 (e-133)

<400>   2562
Met Ile Tyr Ala Gly Ile Leu Ala Gly Gly Thr Gly Thr Arg Met Gly 
1               5                   10                  15      

Ile Ser Asn Leu Pro Lys Gln Phe Leu Glu Leu Gly Asp Arg Pro Ile 
            20                  25                  30          

Leu Ile His Thr Ile Glu Lys Phe Val Leu Glu Pro Ser Ile Glu Lys 
        35                  40                  45              

Ile Val Val Gly Val His Gly Asp Trp Val Ser His Ala Glu Asp Leu 
    50                  55                  60                  

Val Asp Lys Tyr Leu Pro Leu Tyr Lys Glu Arg Ile Ile Ile Thr Lys 
65                  70                  75                  80  

Gly Gly Ala Asp Arg Asn Thr Ser Ile Lys Asn Ile Ile Glu Ala Ile 
                85                  90                  95      

Asp Ala Tyr Arg Pro Leu Thr Pro Glu Asp Ile Val Val Thr His Asp 
            100                 105                 110         

Ser Val Arg Pro Phe Ile Thr Leu Arg Met Ile Gln Asp Asn Ile Gln 
        115                 120                 125             

Leu Ala Gln Asn His Asp Ala Val Asp Thr Val Val Glu Ala Val Asp 
    130                 135                 140                 

Thr Ile Val Glu Ser Thr Asn Gly Gln Phe Ile Thr Asp Ile Pro Asn 
145                 150                 155                 160 

Arg Ala His Leu Tyr Gln Gly Gln Thr Pro Gln Thr Phe Arg Cys Lys 
                165                 170                 175     

Asp Phe Met Asp Leu Tyr Gly Ser Leu Ser Asp Glu Glu Lys Glu Ile 
            180                 185                 190         

Leu Thr Asp Ala Cys Lys Ile Phe Val Ile Lys Gly Lys Asp Val Ala 
        195                 200                 205             

Leu Ala Lys Gly Glu Tyr Ser Asn Leu Lys Ile Thr Thr Val Thr Asp 
    210                 215                 220                 

Leu Lys Ile Ala Lys Ser Met Ile Glu Lys Asp 
225                 230                 235 

<210>   2563
<211>   1485
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2563
atgaaaagta taaaattaaa tgctctatct tacatgggaa ttcgtgtctt gaatattatt   60
tttcccatcc taactggaac ctatgtcgcg cgtgtcttgg accgaactga ctatggttac   120
ttcaactcag tcgacactat tttgtcattt ttcttgccct ttgcaactta tggtgtctat   180
aactacggtt taagggctat cagtaatgtc aaggataaca aaaaagatct taacagaacc   240
ttttctagtc ttttttattt gtgcatcgct tgtacgattt tgaccactgc tgtctatatc   300
ctagcctatc ctctcttctt tactgataat ccaatcgtca aaaaggtcta ccttgttatg   360
gggattcaac tcattgccca gattttttca atcgaatggg tcaatgaagc tctggaaaat   420
tacagttttc tcttttacaa aactgccttc atccgtatcc tgatgctggt ctctattttc   480
ttatttgtta aaaatgaaca cgatattgtt gtctatacac ttgtgatgag tttatcgacg   540
ctgattaact acctgattag ttatttttgg attaaaagag acatcaaact tgttaaaatt   600
cacctaagtg attttaaacc actctttctc cctctgacag ccatgttagt ctttgccaat   660
gccaatatgc tcttcacttt tttagatcgc ctcttcctcg ttaaaacagg gattgatgtc   720
aacgttagtt actataccat agctcagcga attgtgaccg ttatagctgg ggttgtaaca   780
ggtgcaattg gagtgagtgt gcctcgtctc agttactatc tggggaaagg agacaaagaa   840
gcctatgttt ctctggttaa tagaggtagt cgaatcttta acttctttat cattccactg   900
agttttggac tcatggtttt aggaccaaat gccatcctac tttacggtag tgaaaaatat   960
atcggaggcg gcatcttgac ctctctcttc gcttttcgta cgattatcct ggccttagat   1020
accattcttg gttcccaaat tctctttacc aatggctatg aaaaacgtat cacagtctat   1080
acagtctttg ctgggctact caatttgggc ttgaatagtc tccttttttt caaccatatc   1140
gtggctcctg aatactactt actgacaact atgctatcag agacttctct acttgttttc   1200
tatatcattt tcatccatag aaaacaactc atccacttgg gacatatctt tagctatact   1260
gttcgatact ctctcttttc actttccttt gtagcaattt atttcctgat taatttcgtg   1320
tatcctgtag atatggtcat taatttgcca tttttgatta atactggttt gattgtcttg   1380
ctatcagcta tctcttatat tagtctactt gtcttcacaa aagatagcat tttctatgaa   1440
tttttaaacc atgtcctagc cttaaaaaat aaatttaaaa aatca                   1485

<210>   2564
<211>   495
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   polysaccharide biosynthesis protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903193 (0.E+01)

<400>   2564
Met Lys Ser Ile Lys Leu Asn Ala Leu Ser Tyr Met Gly Ile Arg Val 
1               5                   10                  15      

Leu Asn Ile Ile Phe Pro Ile Leu Thr Gly Thr Tyr Val Ala Arg Val 
            20                  25                  30          

Leu Asp Arg Thr Asp Tyr Gly Tyr Phe Asn Ser Val Asp Thr Ile Leu 
        35                  40                  45              

Ser Phe Phe Leu Pro Phe Ala Thr Tyr Gly Val Tyr Asn Tyr Gly Leu 
    50                  55                  60                  


Arg Ala Ile Ser Asn Val Lys Asp Asn Lys Lys Asp Leu Asn Arg Thr 
65                  70                  75                  80  

Phe Ser Ser Leu Phe Tyr Leu Cys Ile Ala Cys Thr Ile Leu Thr Thr 
                85                  90                  95      

Ala Val Tyr Ile Leu Ala Tyr Pro Leu Phe Phe Thr Asp Asn Pro Ile 
            100                 105                 110         

Val Lys Lys Val Tyr Leu Val Met Gly Ile Gln Leu Ile Ala Gln Ile 
        115                 120                 125             

Phe Ser Ile Glu Trp Val Asn Glu Ala Leu Glu Asn Tyr Ser Phe Leu 
    130                 135                 140                 

Phe Tyr Lys Thr Ala Phe Ile Arg Ile Leu Met Leu Val Ser Ile Phe 
145                 150                 155                 160 

Leu Phe Val Lys Asn Glu His Asp Ile Val Val Tyr Thr Leu Val Met 
                165                 170                 175     

Ser Leu Ser Thr Leu Ile Asn Tyr Leu Ile Ser Tyr Phe Trp Ile Lys 
            180                 185                 190         

Arg Asp Ile Lys Leu Val Lys Ile His Leu Ser Asp Phe Lys Pro Leu 
        195                 200                 205             

Phe Leu Pro Leu Thr Ala Met Leu Val Phe Ala Asn Ala Asn Met Leu 
    210                 215                 220                 

Phe Thr Phe Leu Asp Arg Leu Phe Leu Val Lys Thr Gly Ile Asp Val 
225                 230                 235                 240 

Asn Val Ser Tyr Tyr Thr Ile Ala Gln Arg Ile Val Thr Val Ile Ala 
                245                 250                 255     

Gly Val Val Thr Gly Ala Ile Gly Val Ser Val Pro Arg Leu Ser Tyr 
            260                 265                 270         

Tyr Leu Gly Lys Gly Asp Lys Glu Ala Tyr Val Ser Leu Val Asn Arg 
        275                 280                 285             

Gly Ser Arg Ile Phe Asn Phe Phe Ile Ile Pro Leu Ser Phe Gly Leu 
    290                 295                 300                 

Met Val Leu Gly Pro Asn Ala Ile Leu Leu Tyr Gly Ser Glu Lys Tyr 
305                 310                 315                 320 

Ile Gly Gly Gly Ile Leu Thr Ser Leu Phe Ala Phe Arg Thr Ile Ile 
                325                 330                 335     

Leu Ala Leu Asp Thr Ile Leu Gly Ser Gln Ile Leu Phe Thr Asn Gly 
            340                 345                 350         

Tyr Glu Lys Arg Ile Thr Val Tyr Thr Val Phe Ala Gly Leu Leu Asn 
        355                 360                 365             

Leu Gly Leu Asn Ser Leu Leu Phe Phe Asn His Ile Val Ala Pro Glu 
    370                 375                 380                 

Tyr Tyr Leu Leu Thr Thr Met Leu Ser Glu Thr Ser Leu Leu Val Phe 
385                 390                 395                 400 

Tyr Ile Ile Phe Ile His Arg Lys Gln Leu Ile His Leu Gly His Ile 
                405                 410                 415     

Phe Ser Tyr Thr Val Arg Tyr Ser Leu Phe Ser Leu Ser Phe Val Ala 
            420                 425                 430         

Ile Tyr Phe Leu Ile Asn Phe Val Tyr Pro Val Asp Met Val Ile Asn 
        435                 440                 445             

Leu Pro Phe Leu Ile Asn Thr Gly Leu Ile Val Leu Leu Ser Ala Ile 
    450                 455                 460                 

Ser Tyr Ile Ser Leu Leu Val Phe Thr Lys Asp Ser Ile Phe Tyr Glu 
465                 470                 475                 480 

Phe Leu Asn His Val Leu Ala Leu Lys Asn Lys Phe Lys Lys Ser 
                485                 490                 495 

<210>   2565
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2565
atgaaacaac taaccgttga agatgccaaa caaattgaat tagaaatttt ggattatatt   60
gatactctct gtaaaaagca caatatcaac tatattatta actacggtac tctgattggg   120
gcggttcgac atgagggctt tatcccttgg gacgacgata ttgatctgtc catgcctaga   180
gaagactacc aacgatttat taacattttt caaaaggaaa aaagcaagta taagctccta   240
tccttagaaa ctgataagaa ctactttaac aactttatca agataaccga cagtacgact   300
aaaattattg atactcgaaa tacaaaaacc tatgagtctg gtatctttat cgatattttc   360
cctatagatc gctttgatga tcctaaggtc attgatactt gttataaact ggaaagcttc   420
aaactgctgt ctttcagtaa acataaaaat attgtctata aggatagcct tttaaaagat   480
tggatacgaa cagccttctg gttactcctt cgaccggttt ctcctcgtta ttttgcaaat   540
aaaatcgaga aagaaattca aaaatatagt cgtgaaaatg ggcaatatat ggcttttatc   600
ccttcaaaat ttaaggaaaa ggaagtcttc ccaagtggta cctttgataa aacaatcgat   660
ttaccctttg agaatttaag ccttcctgca cctgaaaaat ttgatactat tttgacacaa   720
ttttatggag attatatgac cctaccacca gaagaaaaac gcttctacag tcatgaattt   780
cacgcttata aattggagga t                                             801

<210>   2566
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   licD1 protein (licD1)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903194 (e-158)

<400>   2566
Met Lys Gln Leu Thr Val Glu Asp Ala Lys Gln Ile Glu Leu Glu Ile 
1               5                   10                  15      

Leu Asp Tyr Ile Asp Thr Leu Cys Lys Lys His Asn Ile Asn Tyr Ile 
            20                  25                  30          

Ile Asn Tyr Gly Thr Leu Ile Gly Ala Val Arg His Glu Gly Phe Ile 
        35                  40                  45              

Pro Trp Asp Asp Asp Ile Asp Leu Ser Met Pro Arg Glu Asp Tyr Gln 
    50                  55                  60                  

Arg Phe Ile Asn Ile Phe Gln Lys Glu Lys Ser Lys Tyr Lys Leu Leu 
65                  70                  75                  80  

Ser Leu Glu Thr Asp Lys Asn Tyr Phe Asn Asn Phe Ile Lys Ile Thr 
                85                  90                  95      

Asp Ser Thr Thr Lys Ile Ile Asp Thr Arg Asn Thr Lys Thr Tyr Glu 
            100                 105                 110         

Ser Gly Ile Phe Ile Asp Ile Phe Pro Ile Asp Arg Phe Asp Asp Pro 
        115                 120                 125             

Lys Val Ile Asp Thr Cys Tyr Lys Leu Glu Ser Phe Lys Leu Leu Ser 
    130                 135                 140                 

Phe Ser Lys His Lys Asn Ile Val Tyr Lys Asp Ser Leu Leu Lys Asp 
145                 150                 155                 160 

Trp Ile Arg Thr Ala Phe Trp Leu Leu Leu Arg Pro Val Ser Pro Arg 
                165                 170                 175     

Tyr Phe Ala Asn Lys Ile Glu Lys Glu Ile Gln Lys Tyr Ser Arg Glu 
            180                 185                 190         

Asn Gly Gln Tyr Met Ala Phe Ile Pro Ser Lys Phe Lys Glu Lys Glu 
        195                 200                 205             

Val Phe Pro Ser Gly Thr Phe Asp Lys Thr Ile Asp Leu Pro Phe Glu 
    210                 215                 220                 

Asn Leu Ser Leu Pro Ala Pro Glu Lys Phe Asp Thr Ile Leu Thr Gln 
225                 230                 235                 240 

Phe Tyr Gly Asp Tyr Met Thr Leu Pro Pro Glu Glu Lys Arg Phe Tyr 
                245                 250                 255     

Ser His Glu Phe His Ala Tyr Lys Leu Glu Asp 
            260                 265         

<210>   2567
<211>   840
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2567
atgaatttca cgcttataaa ttggaggatt aggatgcaat atttagaaaa aaaagaaatt   60
aaagaaattc aactagccct gctggactat attgatgaga cttgtaagaa acatgatatt   120
ccttattttc tcagttatgg aaccatgctt ggagccatcc gccacaaagg tatgattcct   180
tgggatgatg atattgatat ttccctttat cgtgaggatt atgagcgttt actgaagatt   240
attgaagaag aaaatcaccc tcgctacaag gttctttcct acgatacatc ttcttggtac   300
ttccataatt tcgcatcgat tttggacact tctactgtta tagaagacca tgttaagtac   360
aagcgtcatg ataccagcct tttcatcgat gtcttcccaa ttgatcgatt tacagacttg   420
agcattgtcg acaagagcta taagtatgtg gctcttcgtc aactagctta tatcaaaaaa   480
tcacgagcag ttcacggtga tagcaaacta aaagattttc ttagattatg tagctggtac   540
gctctccgat ttgtcaatcc tcgctacttt tacaagaaaa ttgatcaact agtcaaaaat   600
gctgtaacca acactcctca atatgaagga ggagttggga tcggtaagga agggatgaaa   660
gaaatcttcc cagttgatac ctttaaagaa ctgattttaa ctgagtttga gggccgtatg   720
ttgcctgttc ccaaaaaata tgaccaattt ttaacccaga tgtatggcga ttatatgaca   780
ccaccatcaa aagaaatgca agagtggtat agtcatagca ttaaagctta tcgcaaaaac   840

<210>   2568
<211>   280
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   licD2 protein (licD2)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903195 (e-160)

<400>   2568
Met Asn Phe Thr Leu Ile Asn Trp Arg Ile Arg Met Gln Tyr Leu Glu 
1               5                   10                  15      

Lys Lys Glu Ile Lys Glu Ile Gln Leu Ala Leu Leu Asp Tyr Ile Asp 
            20                  25                  30          

Glu Thr Cys Lys Lys His Asp Ile Pro Tyr Phe Leu Ser Tyr Gly Thr 
        35                  40                  45              

Met Leu Gly Ala Ile Arg His Lys Gly Met Ile Pro Trp Asp Asp Asp 
    50                  55                  60                  

Ile Asp Ile Ser Leu Tyr Arg Glu Asp Tyr Glu Arg Leu Leu Lys Ile 
65                  70                  75                  80  

Ile Glu Glu Glu Asn His Pro Arg Tyr Lys Val Leu Ser Tyr Asp Thr 
                85                  90                  95      

Ser Ser Trp Tyr Phe His Asn Phe Ala Ser Ile Leu Asp Thr Ser Thr 
            100                 105                 110         

Val Ile Glu Asp His Val Lys Tyr Lys Arg His Asp Thr Ser Leu Phe 
        115                 120                 125             

Ile Asp Val Phe Pro Ile Asp Arg Phe Thr Asp Leu Ser Ile Val Asp 

    130                 135                 140                 

Lys Ser Tyr Lys Tyr Val Ala Leu Arg Gln Leu Ala Tyr Ile Lys Lys 
145                 150                 155                 160 

Ser Arg Ala Val His Gly Asp Ser Lys Leu Lys Asp Phe Leu Arg Leu 
                165                 170                 175     

Cys Ser Trp Tyr Ala Leu Arg Phe Val Asn Pro Arg Tyr Phe Tyr Lys 
            180                 185                 190         

Lys Ile Asp Gln Leu Val Lys Asn Ala Val Thr Asn Thr Pro Gln Tyr 
        195                 200                 205             

Glu Gly Gly Val Gly Ile Gly Lys Glu Gly Met Lys Glu Ile Phe Pro 
    210                 215                 220                 

Val Asp Thr Phe Lys Glu Leu Ile Leu Thr Glu Phe Glu Gly Arg Met 
225                 230                 235                 240 

Leu Pro Val Pro Lys Lys Tyr Asp Gln Phe Leu Thr Gln Met Tyr Gly 
                245                 250                 255     

Asp Tyr Met Thr Pro Pro Ser Lys Glu Met Gln Glu Trp Tyr Ser His 
            260                 265                 270         

Ser Ile Lys Ala Tyr Arg Lys Asn 
        275                 280 

<210>   2569
<211>   3174
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2569
atgcctaaac gtactgatat tcaaaaaatt atggtgattg gttctggtcc gattattatt   60
ggtcaggctg ctgagtttga ctacgctggg actcaggctt gcttgtcgtt gaaagaggaa   120
ggttatgagg ttgttttggt taactcaaat cctgcaacca tcatgacgga caaggaaatt   180
gctgacaagg tttacattga accgattaca cttgagtttg tgacacgtat tcttcgtaag   240
gaaggtccag atgccttgct accaacactc ggtggtcaga caggtctcaa catggccatg   300
gaattatcta aaaatggtat cctagacgag cttggcgttg aacttctggg taccaaatta   360
tctgccattg accaagcgga ggaccgtgac ctctttaaac aattgatgga agagcttgaa   420
caacccattc cagaatctga aattgttaac acagtagaag aagcagttgc ctttgcagcg   480
acaattggct acccagtcat cgttcgtcca gcctttaccc ttggtggtac tggtggtggt   540
atgtgtgcca acgagaaaga attgcgtgaa atcactgaaa atggtttgaa attgtcacct   600
gttacccaat gtttgattga gcgttcgatt gccggtttca aggaaattga atacgaagtg   660
atgcgtgact cagctgacaa tgccttggtt gtttgtaaca tggaaaactt tgacccagtt   720
gggattcaca caggggattc cattgtattt gcccctgcgc aaaccatgtc agactatgaa   780
aaccaaatgc ttcgtgatgc gagcttgagc attattcgtg ccctcaagat tgaaggtgga   840
tgtaatgttc agctagctct tgatcctaac agcttcaagt attatgttat cgaagtaaac   900
cctcgtgtat cacgttcgtc agcccttgct tctaaagcga caggatatcc gattgctaag   960
ttggctgcca agattgcagt aggtttgacc ttggatgagg ttataaaccc agttacaggt   1020
tcaacctatg ccatgtttga accagccctt gactacgtag ttgctaagat tccacgtttc   1080
ccatttgaca agtttgaaaa gggtgaacgc cgtctcggta cacaaatgaa ggcgactgga   1140
gaagtcatgg caatcggtcg taacatcgag gaatctcttc tcaaggcctg ccgctccctt   1200
gaaattgggg tgcaccacaa tgaaatacct gaacttgcag cagtttctga tgatgccttg   1260
attgaaaagg ttgtcaaagc ccaagatgac cgtctcttct acgtatcaga agccattcgt   1320
cgtggctaca cacctgaaga aattgcagag cttacaaaaa ttgatatctt ctatcttgat   1380
aaactcttgc atatctttga aattgagcaa gaattgggtg ctcatccaca agatttagaa   1440
gttttgaaaa cagccaaact taatggtttt tcagaccgta agattgctga actctgggga   1500
acgactgatg ataaagttcg ccaacttcgc ttggaaaaca agattgttcc agtttataag   1560
atggtagaca cttgtgcggc agagttcgac tccgaaacgc catatttcta ttcaacctat   1620
ggttgggaaa atgaatctat cagatctgat aaagaatctg tacttgtcct aggttcaggt   1680
ccaatccgta tcggtcaagg ggttgagttt gactacgcaa ccgttcactc tgttaaggct   1740
atccaggcag ctggttatga agctatcatc atgaactcaa acccagagac cgtttcaaca   1800
gacttctctg tatcagataa gctttacttt gagccattga cattcgaaga tgttatgaac   1860
gtcattgact tggaacaacc aaagggagtt atcgttcagt tcggtggtca aacagccatc   1920
aaccttgcgg agccattggc aaaagcaggt gtgaccatcc ttggtacaca ggttgctgac   1980
ctagatcgtg ccgaagaccg tgacctcttc gagcaagctc tcaaagaatt ggatattcca   2040
cagccaccag gacaaacggc taccaatgaa gaagaagcag ctcttgcagc tcgcaagatt   2100
ggcttcccag ttcttgtccg cccatcttat gtacttggtg gacgtgccat ggaaatcgtt   2160
gaaaacgaag aagaccttcg ttcttacatg cgaactgctg ttaaggctag tccagaccac   2220
ccagttcttg tcgactctta tatcgttggg caagagtgcg aagttgatgc catttcagat   2280

ggtaaaaatg tactcattcc tggtatcatg gagcatatcg aacgtgctgg tgtccactca   2340
ggtgactcaa tggctgttta cccaccacaa accttgtcgc aaaaggttca ggagaccatc   2400
gcagactaca ccaaacgctt agcaatcggt cttcactgcc ttggaatgat gaacatccag   2460
tttgttatca aggatgaaaa agtctacgtt attgaggtca atccacgtgc cagccgtact   2520
gttccattcc tatctaaggt aaccaatatt cctatggctc aagtagcgac caaactcatt   2580
cttggtcaaa gtttatcaga acttggctac caaaatggac tttaccctga aagcacccgt   2640
gttcatatca aggcacctgt cttctccttt accaaactag ctaaggtaga cagcttgctc   2700
ggtcctgaaa tgaagtcaac aggtgaagtt atgggttctg atgctacttt ggaaaaagct   2760
ctctataaag cctttgaagc ttcttatcta cacttgccaa cttttggtaa tgtcgtcttt   2820
accatcgctg atgatgccaa agaagaagcc ttgaacttgg ctcgtcgttt ccaaaacatt   2880
ggttatggaa tccttgcgac agaagggaca gcagccttct ttgctagtca tggcttgcaa   2940
gcccaacctg ttggtaagat tggtgatgac gataaggata tcccaagttt tgtacgcaaa   3000
ggaagaattc aagctatcat taacacagta ggaacaaaac gaactgctga cgaagatggt   3060
gagcaaattc gtcgttcagc cattgaacac ggggtgcccc tcttcacagc gctagataca   3120
gctaatgcca tgcttaaggt acttgaaagt cgtagctttg ttacagaagc gatt         3174

<210>   2570
<211>   1058
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   carbamoyl-phosphate synthase, large subunit (carB)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903196 (0.E+01)

<400>   2570
Met Pro Lys Arg Thr Asp Ile Gln Lys Ile Met Val Ile Gly Ser Gly 
1               5                   10                  15      

Pro Ile Ile Ile Gly Gln Ala Ala Glu Phe Asp Tyr Ala Gly Thr Gln 
            20                  25                  30          

Ala Cys Leu Ser Leu Lys Glu Glu Gly Tyr Glu Val Val Leu Val Asn 
        35                  40                  45              

Ser Asn Pro Ala Thr Ile Met Thr Asp Lys Glu Ile Ala Asp Lys Val 
    50                  55                  60                  

Tyr Ile Glu Pro Ile Thr Leu Glu Phe Val Thr Arg Ile Leu Arg Lys 
65                  70                  75                  80  

Glu Gly Pro Asp Ala Leu Leu Pro Thr Leu Gly Gly Gln Thr Gly Leu 
                85                  90                  95      

Asn Met Ala Met Glu Leu Ser Lys Asn Gly Ile Leu Asp Glu Leu Gly 
            100                 105                 110         

Val Glu Leu Leu Gly Thr Lys Leu Ser Ala Ile Asp Gln Ala Glu Asp 
        115                 120                 125             

Arg Asp Leu Phe Lys Gln Leu Met Glu Glu Leu Glu Gln Pro Ile Pro 
    130                 135                 140                 

Glu Ser Glu Ile Val Asn Thr Val Glu Glu Ala Val Ala Phe Ala Ala 
145                 150                 155                 160 

Thr Ile Gly Tyr Pro Val Ile Val Arg Pro Ala Phe Thr Leu Gly Gly 
                165                 170                 175     

Thr Gly Gly Gly Met Cys Ala Asn Glu Lys Glu Leu Arg Glu Ile Thr 
            180                 185                 190         

Glu Asn Gly Leu Lys Leu Ser Pro Val Thr Gln Cys Leu Ile Glu Arg 
        195                 200                 205             

Ser Ile Ala Gly Phe Lys Glu Ile Glu Tyr Glu Val Met Arg Asp Ser 
    210                 215                 220                 

Ala Asp Asn Ala Leu Val Val Cys Asn Met Glu Asn Phe Asp Pro Val 
225                 230                 235                 240 

Gly Ile His Thr Gly Asp Ser Ile Val Phe Ala Pro Ala Gln Thr Met 
                245                 250                 255     

Ser Asp Tyr Glu Asn Gln Met Leu Arg Asp Ala Ser Leu Ser Ile Ile 
            260                 265                 270         

Arg Ala Leu Lys Ile Glu Gly Gly Cys Asn Val Gln Leu Ala Leu Asp 
        275                 280                 285             

Pro Asn Ser Phe Lys Tyr Tyr Val Ile Glu Val Asn Pro Arg Val Ser 
    290                 295                 300                 

Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Ile Ala Lys 
305                 310                 315                 320 

Leu Ala Ala Lys Ile Ala Val Gly Leu Thr Leu Asp Glu Val Ile Asn 
                325                 330                 335     

Pro Val Thr Gly Ser Thr Tyr Ala Met Phe Glu Pro Ala Leu Asp Tyr 
            340                 345                 350         

Val Val Ala Lys Ile Pro Arg Phe Pro Phe Asp Lys Phe Glu Lys Gly 
        355                 360                 365             


Glu Arg Arg Leu Gly Thr Gln Met Lys Ala Thr Gly Glu Val Met Ala 
    370                 375                 380                 

Ile Gly Arg Asn Ile Glu Glu Ser Leu Leu Lys Ala Cys Arg Ser Leu 
385                 390                 395                 400 

Glu Ile Gly Val His His Asn Glu Ile Pro Glu Leu Ala Ala Val Ser 
                405                 410                 415     

Asp Asp Ala Leu Ile Glu Lys Val Val Lys Ala Gln Asp Asp Arg Leu 
            420                 425                 430         

Phe Tyr Val Ser Glu Ala Ile Arg Arg Gly Tyr Thr Pro Glu Glu Ile 
        435                 440                 445             

Ala Glu Leu Thr Lys Ile Asp Ile Phe Tyr Leu Asp Lys Leu Leu His 
    450                 455                 460                 

Ile Phe Glu Ile Glu Gln Glu Leu Gly Ala His Pro Gln Asp Leu Glu 
465                 470                 475                 480 

Val Leu Lys Thr Ala Lys Leu Asn Gly Phe Ser Asp Arg Lys Ile Ala 
                485                 490                 495     

Glu Leu Trp Gly Thr Thr Asp Asp Lys Val Arg Gln Leu Arg Leu Glu 
            500                 505                 510         

Asn Lys Ile Val Pro Val Tyr Lys Met Val Asp Thr Cys Ala Ala Glu 
        515                 520                 525             

Phe Asp Ser Glu Thr Pro Tyr Phe Tyr Ser Thr Tyr Gly Trp Glu Asn 
    530                 535                 540                 

Glu Ser Ile Arg Ser Asp Lys Glu Ser Val Leu Val Leu Gly Ser Gly 
545                 550                 555                 560 

Pro Ile Arg Ile Gly Gln Gly Val Glu Phe Asp Tyr Ala Thr Val His 
                565                 570                 575     

Ser Val Lys Ala Ile Gln Ala Ala Gly Tyr Glu Ala Ile Ile Met Asn 
            580                 585                 590         

Ser Asn Pro Glu Thr Val Ser Thr Asp Phe Ser Val Ser Asp Lys Leu 
        595                 600                 605             

Tyr Phe Glu Pro Leu Thr Phe Glu Asp Val Met Asn Val Ile Asp Leu 
    610                 615                 620                 

Glu Gln Pro Lys Gly Val Ile Val Gln Phe Gly Gly Gln Thr Ala Ile 
625                 630                 635                 640 

Asn Leu Ala Glu Pro Leu Ala Lys Ala Gly Val Thr Ile Leu Gly Thr 
                645                 650                 655     

Gln Val Ala Asp Leu Asp Arg Ala Glu Asp Arg Asp Leu Phe Glu Gln 
            660                 665                 670         

Ala Leu Lys Glu Leu Asp Ile Pro Gln Pro Pro Gly Gln Thr Ala Thr 
        675                 680                 685             

Asn Glu Glu Glu Ala Ala Leu Ala Ala Arg Lys Ile Gly Phe Pro Val 
    690                 695                 700                 


Leu Val Arg Pro Ser Tyr Val Leu Gly Gly Arg Ala Met Glu Ile Val 
705                 710                 715                 720 

Glu Asn Glu Glu Asp Leu Arg Ser Tyr Met Arg Thr Ala Val Lys Ala 
                725                 730                 735     

Ser Pro Asp His Pro Val Leu Val Asp Ser Tyr Ile Val Gly Gln Glu 
            740                 745                 750         

Cys Glu Val Asp Ala Ile Ser Asp Gly Lys Asn Val Leu Ile Pro Gly 
        755                 760                 765             

Ile Met Glu His Ile Glu Arg Ala Gly Val His Ser Gly Asp Ser Met 
    770                 775                 780                 

Ala Val Tyr Pro Pro Gln Thr Leu Ser Gln Lys Val Gln Glu Thr Ile 
785                 790                 795                 800 

Ala Asp Tyr Thr Lys Arg Leu Ala Ile Gly Leu His Cys Leu Gly Met 
                805                 810                 815     

Met Asn Ile Gln Phe Val Ile Lys Asp Glu Lys Val Tyr Val Ile Glu 
            820                 825                 830         

Val Asn Pro Arg Ala Ser Arg Thr Val Pro Phe Leu Ser Lys Val Thr 
        835                 840                 845             

Asn Ile Pro Met Ala Gln Val Ala Thr Lys Leu Ile Leu Gly Gln Ser 
    850                 855                 860                 

Leu Ser Glu Leu Gly Tyr Gln Asn Gly Leu Tyr Pro Glu Ser Thr Arg 
865                 870                 875                 880 

Val His Ile Lys Ala Pro Val Phe Ser Phe Thr Lys Leu Ala Lys Val 
                885                 890                 895     

Asp Ser Leu Leu Gly Pro Glu Met Lys Ser Thr Gly Glu Val Met Gly 
            900                 905                 910         

Ser Asp Ala Thr Leu Glu Lys Ala Leu Tyr Lys Ala Phe Glu Ala Ser 
        915                 920                 925             

Tyr Leu His Leu Pro Thr Phe Gly Asn Val Val Phe Thr Ile Ala Asp 
    930                 935                 940                 

Asp Ala Lys Glu Glu Ala Leu Asn Leu Ala Arg Arg Phe Gln Asn Ile 
945                 950                 955                 960 

Gly Tyr Gly Ile Leu Ala Thr Glu Gly Thr Ala Ala Phe Phe Ala Ser 
                965                 970                 975     

His Gly Leu Gln Ala Gln Pro Val Gly Lys Ile Gly Asp Asp Asp Lys 
            980                 985                 990         

Asp Ile Pro Ser Phe Val Arg Lys Gly Arg Ile Gln Ala Ile Ile Asn 
        995                 1000                1005            

Thr Val Gly Thr Lys Arg Thr Ala Asp Glu Asp Gly Glu Gln Ile Arg 
    1010                1015                1020                

Arg Ser Ala Ile Glu His Gly Val Pro Leu Phe Thr Ala Leu Asp Thr 
1025                1030                1035                1040

Ala Asn Ala Met Leu Lys Val Leu Glu Ser Arg Ser Phe Val Thr Glu 
                1045                1050                1055    

Ala Ile 
        

<210>   2571
<211>   1077
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2571
atgacaaaaa gaattctagt attagaagat ggcacagttt ttgaaggcaa ggccttcgga   60
gcagatattg atgtaacagg cgaaatcgtc tttaatacag ggatgaccgg ctaccaagaa   120
tccattacag accagtctta taatggacaa atcttgacct ttacttatcc tttggtagga   180
aattatggta ttaatcgtga tgattatgaa tccattattc caacttgtaa gggagtcgtt   240
gtttttgaag aagcgcgtag agctagcaac tggcgcaacc aaatgacctt ggatgaattt   300
ttgaaagcca agaaaattcc agggatttca ggaattgata cgcgtgctct taccaagatt   360
atccgtaagc atggtactat gcgtgcaacc ttgacccatg ttggggacag tatggaccat   420
gtgacggacc agctccaagc aacagtttta ccgacagaca atatcaaaca ggtttctact   480
aaaacgtctt atccagctcc aggagttggt ttgagcgtgg tgctagtgga ctttggtctc   540
aagcactcaa tcctacgtga actttctaaa cgcaactgta acgtgacagt tgttccttat   600
tcgacaacgg ctgaagaaat tctccatctc aatcctgacg gagttatgtt gtcaaatggt   660
ccaggtaacc cagaagacgt tccacaagca ctcgacatga ttcgcggtgt acaaggaaaa   720
attccaatct ttggtatttg tatgggacac caactctttg caatggcaaa cggggctaag   780
acctataaga tgaagtttgg ccaccgtgga ttcaaccatg cggtacgtga aatcgcaaca   840
ggacgagtag acttcaccag ccagaaccat ggttatgcag tcagccgcga ggatttgcca   900
gagcacttga ttattaccca cgaagaaatc aatgacaagt cagtggaagg tgtgcgccac   960
agataccaac ctgctttctc tgttcaatac cacccagatg cagctcctgg gccacacgac   1020
gctagctacc tatttgacga gtttatcgag atgatggaag tttttaaaca atcaaac      1077

<210>   2572
<211>   359
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   carbamoyl-phosphate synthase, small subunit (carA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903197 (0.E+01)

<400>   2572
Met Thr Lys Arg Ile Leu Val Leu Glu Asp Gly Thr Val Phe Glu Gly 
1               5                   10                  15      

Lys Ala Phe Gly Ala Asp Ile Asp Val Thr Gly Glu Ile Val Phe Asn 
            20                  25                  30          

Thr Gly Met Thr Gly Tyr Gln Glu Ser Ile Thr Asp Gln Ser Tyr Asn 
        35                  40                  45              

Gly Gln Ile Leu Thr Phe Thr Tyr Pro Leu Val Gly Asn Tyr Gly Ile 
    50                  55                  60                  

Asn Arg Asp Asp Tyr Glu Ser Ile Ile Pro Thr Cys Lys Gly Val Val 
65                  70                  75                  80  

Val Phe Glu Glu Ala Arg Arg Ala Ser Asn Trp Arg Asn Gln Met Thr 
                85                  90                  95      

Leu Asp Glu Phe Leu Lys Ala Lys Lys Ile Pro Gly Ile Ser Gly Ile 
            100                 105                 110         

Asp Thr Arg Ala Leu Thr Lys Ile Ile Arg Lys His Gly Thr Met Arg 
        115                 120                 125             

Ala Thr Leu Thr His Val Gly Asp Ser Met Asp His Val Thr Asp Gln 
    130                 135                 140                 

Leu Gln Ala Thr Val Leu Pro Thr Asp Asn Ile Lys Gln Val Ser Thr 
145                 150                 155                 160 

Lys Thr Ser Tyr Pro Ala Pro Gly Val Gly Leu Ser Val Val Leu Val 
                165                 170                 175     

Asp Phe Gly Leu Lys His Ser Ile Leu Arg Glu Leu Ser Lys Arg Asn 
            180                 185                 190         

Cys Asn Val Thr Val Val Pro Tyr Ser Thr Thr Ala Glu Glu Ile Leu 
        195                 200                 205             

His Leu Asn Pro Asp Gly Val Met Leu Ser Asn Gly Pro Gly Asn Pro 
    210                 215                 220                 

Glu Asp Val Pro Gln Ala Leu Asp Met Ile Arg Gly Val Gln Gly Lys 
225                 230                 235                 240 

Ile Pro Ile Phe Gly Ile Cys Met Gly His Gln Leu Phe Ala Met Ala 
                245                 250                 255     

Asn Gly Ala Lys Thr Tyr Lys Met Lys Phe Gly His Arg Gly Phe Asn 
            260                 265                 270         

His Ala Val Arg Glu Ile Ala Thr Gly Arg Val Asp Phe Thr Ser Gln 
        275                 280                 285             

Asn His Gly Tyr Ala Val Ser Arg Glu Asp Leu Pro Glu His Leu Ile 
    290                 295                 300                 

Ile Thr His Glu Glu Ile Asn Asp Lys Ser Val Glu Gly Val Arg His 
305                 310                 315                 320 

Arg Tyr Gln Pro Ala Phe Ser Val Gln Tyr His Pro Asp Ala Ala Pro 
                325                 330                 335     

Gly Pro His Asp Ala Ser Tyr Leu Phe Asp Glu Phe Ile Glu Met Met 
            340                 345                 350         

Glu Val Phe Lys Gln Ser Asn 
        355                 

<210>   2573
<211>   921
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2573
atgtcagaaa atcaacaagc attgaaccat gtggtgtcca tggaagacct cactgtcgat   60
caagtaatga aattgatcaa gcgaggaatt gagtttaaaa atggagccca gcttccctat   120
gaagaccatc cgattgtttc caatctcttc tttgaggatt ctacacggac acataagtcc   180
tttgaagtcg cagagattaa acttggattg gaacgacttg actttgatgt gaagactagc   240
tcggttaata agggtgagac actttatgac accattttga ctctgtctgc tttaggagtg   300
gatgtctgtg tgattcgcca tccagaggtc gactactata gagaattgat tgctagtcca   360
acgattacga cttccatcat caatggtgga gatggttcgg gccaacaccc tagccagagc   420
ttgcttgatt tgatgaccat ttatgaggaa tttggccact ttgagggtct taaagttgct   480
attgcaggtg acttggacca ctcacgcgtt gccaaatcca atatgcagat tttgaaacgc   540
ttgggagctg aactcttttt cgctggacct gaggaatgga gaagtcaaga gtttgcagac   600
tatggacagt ttgtaaccat tgatgaaatc attgatcagg ttgatgtcat gatgtttctc   660
cgtgtgcaac acgaacgcca tgatagtgga gctgtatttt caaaagaaga ctaccatgcc   720
caacatggct tgactcaaga acgttacgat cgtttgaaag aaacagcaat cctcatgcac   780
ccagctccaa tcaatcgtga tgtagaaata gcagaccact tggttgaagc accaaaatca   840
cggattgtcc aacaaatgac caatggtgtc tttgttcgaa tggcaatctt agaatccgta   900
ctagcgagta gaaacgccaa c                                             921

<210>   2574
<211>   307
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aspartate carbamoyltransferase (pyrB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903198 (e-175)

<400>   2574
Met Ser Glu Asn Gln Gln Ala Leu Asn His Val Val Ser Met Glu Asp 
1               5                   10                  15      

Leu Thr Val Asp Gln Val Met Lys Leu Ile Lys Arg Gly Ile Glu Phe 
            20                  25                  30          

Lys Asn Gly Ala Gln Leu Pro Tyr Glu Asp His Pro Ile Val Ser Asn 
        35                  40                  45              

Leu Phe Phe Glu Asp Ser Thr Arg Thr His Lys Ser Phe Glu Val Ala 
    50                  55                  60                  

Glu Ile Lys Leu Gly Leu Glu Arg Leu Asp Phe Asp Val Lys Thr Ser 
65                  70                  75                  80  

Ser Val Asn Lys Gly Glu Thr Leu Tyr Asp Thr Ile Leu Thr Leu Ser 
                85                  90                  95      

Ala Leu Gly Val Asp Val Cys Val Ile Arg His Pro Glu Val Asp Tyr 
            100                 105                 110         

Tyr Arg Glu Leu Ile Ala Ser Pro Thr Ile Thr Thr Ser Ile Ile Asn 
        115                 120                 125             

Gly Gly Asp Gly Ser Gly Gln His Pro Ser Gln Ser Leu Leu Asp Leu 
    130                 135                 140                 

Met Thr Ile Tyr Glu Glu Phe Gly His Phe Glu Gly Leu Lys Val Ala 
145                 150                 155                 160 

Ile Ala Gly Asp Leu Asp His Ser Arg Val Ala Lys Ser Asn Met Gln 
                165                 170                 175     

Ile Leu Lys Arg Leu Gly Ala Glu Leu Phe Phe Ala Gly Pro Glu Glu 
            180                 185                 190         

Trp Arg Ser Gln Glu Phe Ala Asp Tyr Gly Gln Phe Val Thr Ile Asp 
        195                 200                 205             

Glu Ile Ile Asp Gln Val Asp Val Met Met Phe Leu Arg Val Gln His 
    210                 215                 220                 

Glu Arg His Asp Ser Gly Ala Val Phe Ser Lys Glu Asp Tyr His Ala 
225                 230                 235                 240 

Gln His Gly Leu Thr Gln Glu Arg Tyr Asp Arg Leu Lys Glu Thr Ala 
                245                 250                 255     

Ile Leu Met His Pro Ala Pro Ile Asn Arg Asp Val Glu Ile Ala Asp 
            260                 265                 270         

His Leu Val Glu Ala Pro Lys Ser Arg Ile Val Gln Gln Met Thr Asn 
        275                 280                 285             

Gly Val Phe Val Arg Met Ala Ile Leu Glu Ser Val Leu Ala Ser Arg 
    290                 295                 300                 

Asn Ala Asn 
305         

<210>   2575
<211>   519
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2575
atgaaaacaa aagaagttgt agacgaattg accgtcaaac gagcgattac gcgtattact   60
tatgagatta tcgaacgcaa caaagatttg aataagatcg tcttggctgg tattaaaact   120
cgtggtgtct ttattgccca ccgaatccaa gaacgtttga agcagttaga aaatctttca   180
gttcctgttg tggaattgga tactaaacct ttccgtgatg atgttaaaag tggagaagat   240
acttctttgg tttctgtcga tgtgacagac cgcgaagtta tcttggtgga tgatgtgctc   300
tatacaggtc gtaccatccg tgctgctatt gataatattg tcggtcatgg tcgtcctgcg   360
cgtgtgagtt tagcagttct agtcgatcgt ggacatagag aattgccaat ccgtccagat   420
tacgttggaa aaaatatccc aaccagtcgt tctgaagaaa tcatcgtaga gatgacagaa   480
cttgatgacc aagacagagt tctgattact gaagaagct                          519

<210>   2576
<211>   173
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyrimidine operon regulatory protein (pyrR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903199 (3.E-93)

<400>   2576
Met Lys Thr Lys Glu Val Val Asp Glu Leu Thr Val Lys Arg Ala Ile 
1               5                   10                  15      

Thr Arg Ile Thr Tyr Glu Ile Ile Glu Arg Asn Lys Asp Leu Asn Lys 
            20                  25                  30          

Ile Val Leu Ala Gly Ile Lys Thr Arg Gly Val Phe Ile Ala His Arg 
        35                  40                  45              

Ile Gln Glu Arg Leu Lys Gln Leu Glu Asn Leu Ser Val Pro Val Val 
    50                  55                  60                  

Glu Leu Asp Thr Lys Pro Phe Arg Asp Asp Val Lys Ser Gly Glu Asp 
65                  70                  75                  80  

Thr Ser Leu Val Ser Val Asp Val Thr Asp Arg Glu Val Ile Leu Val 
                85                  90                  95      

Asp Asp Val Leu Tyr Thr Gly Arg Thr Ile Arg Ala Ala Ile Asp Asn 
            100                 105                 110         

Ile Val Gly His Gly Arg Pro Ala Arg Val Ser Leu Ala Val Leu Val 
        115                 120                 125             

Asp Arg Gly His Arg Glu Leu Pro Ile Arg Pro Asp Tyr Val Gly Lys 
    130                 135                 140                 

Asn Ile Pro Thr Ser Arg Ser Glu Glu Ile Ile Val Glu Met Thr Glu 
145                 150                 155                 160 

Leu Asp Asp Gln Asp Arg Val Leu Ile Thr Glu Glu Ala 
                165                 170             

<210>   2577
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2577
atggtcttgt caaaaaaacg agcacgaaag gtgctagaag aaatcattgc cctcttccca   60
gatgccaagc ctagtcttga ttttaccaat cattttgaac tcctggttgc ggtcatgtta   120
tcagcccaga cgacagatgc agcggtaaat aaggccacac caggtctctt tgttgccttt   180
ccaacacccc aagctatgtc tgtagcgaca gagagtgaga ttgcttcaca tatttctcgc   240
ttgggattgt atcggaataa agctaaattc cttaaaaaat gtgcccaaca gttactagac   300
gattttgatg gtcaagtccc tcagacacgt gaagaattgg agagtttggc aggtgttggt   360
cgcaagacag ccaatgttgt catgagtgta ggatttggaa ttccagcctt tgcagtggat   420
actcatgtgg agcgtatttg caaacaccac gatattgtca aaaaatcagc gacgccactt   480
gaggtggaaa agcgggtcat ggatatcttg ccgcctgagc agtggttagc tgcccatcag   540
gccatgattt attttggaag agccatttgc catccaaaaa atccagagtg tgaccagtac   600
ccacaattat atgattttag caatttg                                       627

<210>   2578
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   endonuclease III (nth)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903200 (e-119)

<400>   2578
Met Val Leu Ser Lys Lys Arg Ala Arg Lys Val Leu Glu Glu Ile Ile 
1               5                   10                  15      

Ala Leu Phe Pro Asp Ala Lys Pro Ser Leu Asp Phe Thr Asn His Phe 
            20                  25                  30          

Glu Leu Leu Val Ala Val Met Leu Ser Ala Gln Thr Thr Asp Ala Ala 
        35                  40                  45              

Val Asn Lys Ala Thr Pro Gly Leu Phe Val Ala Phe Pro Thr Pro Gln 
    50                  55                  60                  

Ala Met Ser Val Ala Thr Glu Ser Glu Ile Ala Ser His Ile Ser Arg 
65                  70                  75                  80  

Leu Gly Leu Tyr Arg Asn Lys Ala Lys Phe Leu Lys Lys Cys Ala Gln 
                85                  90                  95      

Gln Leu Leu Asp Asp Phe Asp Gly Gln Val Pro Gln Thr Arg Glu Glu 
            100                 105                 110         

Leu Glu Ser Leu Ala Gly Val Gly Arg Lys Thr Ala Asn Val Val Met 
        115                 120                 125             

Ser Val Gly Phe Gly Ile Pro Ala Phe Ala Val Asp Thr His Val Glu 
    130                 135                 140                 

Arg Ile Cys Lys His His Asp Ile Val Lys Lys Ser Ala Thr Pro Leu 
145                 150                 155                 160 

Glu Val Glu Lys Arg Val Met Asp Ile Leu Pro Pro Glu Gln Trp Leu 
                165                 170                 175     

Ala Ala His Gln Ala Met Ile Tyr Phe Gly Arg Ala Ile Cys His Pro 
            180                 185                 190         

Lys Asn Pro Glu Cys Asp Gln Tyr Pro Gln Leu Tyr Asp Phe Ser Asn 
        195                 200                 205             

Leu 
    

<210>   2579
<211>   540
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2579
atgaaattaa atattcaaga aattcgtaag cagtctgaag gtttgaactt tgaacaaacg   60
ttagatttag ttgatgacct gcgtgcacgt aatcaagaaa ttttagatgt aaaagatatc   120
cttgcagttg ggaaagtaca atatgaagac cgtatgtatt tcttagatta tcaactatct   180
tataccattg ttcttgcttc gagtcgcagt atggagccag ttgagttagt tgaatcttat   240
ccagtcacgg aagttttcat ggaaggcgca actaaccagc tagatcaaga agttttagat   300
gatgacttgg tcttgcccat cgaaaatggg gagcttgacc ttgctgagag tgtatcagac   360
aatatcctgc taaacattcc tatcaaggtc ttgacggctg aagaagaagc tggtcaagga   420
tttatctcag gaaatgactg gcaaatcatg acagaggaag aataccaagc tcaaaaagca   480
gtaaagaaag aagaaaacag tccttttgct ggcttacaag gactatttga cggagatgaa   540

<210>   2580
<211>   180
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903201 (7.E-99)

<400>   2580
Met Lys Leu Asn Ile Gln Glu Ile Arg Lys Gln Ser Glu Gly Leu Asn 
1               5                   10                  15      

Phe Glu Gln Thr Leu Asp Leu Val Asp Asp Leu Arg Ala Arg Asn Gln 
            20                  25                  30          

Glu Ile Leu Asp Val Lys Asp Ile Leu Ala Val Gly Lys Val Gln Tyr 
        35                  40                  45              

Glu Asp Arg Met Tyr Phe Leu Asp Tyr Gln Leu Ser Tyr Thr Ile Val 
    50                  55                  60                  

Leu Ala Ser Ser Arg Ser Met Glu Pro Val Glu Leu Val Glu Ser Tyr 
65                  70                  75                  80  

Pro Val Thr Glu Val Phe Met Glu Gly Ala Thr Asn Gln Leu Asp Gln 
                85                  90                  95      

Glu Val Leu Asp Asp Asp Leu Val Leu Pro Ile Glu Asn Gly Glu Leu 
            100                 105                 110         

Asp Leu Ala Glu Ser Val Ser Asp Asn Ile Leu Leu Asn Ile Pro Ile 
        115                 120                 125             

Lys Val Leu Thr Ala Glu Glu Glu Ala Gly Gln Gly Phe Ile Ser Gly 
    130                 135                 140                 

Asn Asp Trp Gln Ile Met Thr Glu Glu Glu Tyr Gln Ala Gln Lys Ala 
145                 150                 155                 160 

Val Lys Lys Glu Glu Asn Ser Pro Phe Ala Gly Leu Gln Gly Leu Phe 
                165                 170                 175     

Asp Gly Asp Glu 
            180 

<210>   2581
<211>   363
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2581
gtgctatact atagggaaag agtacatcag atcaaggagg atgctcacat ggaagacaag   60
aaactcattc aactcctatc caagttaaat aaaagctacc aaaactgtaa acagggtacg   120
gcagatgata ttcgactaca agagctgcta aacactacta tgcaagagct caaaaaaacg   180
gaacagttga acaacagtat cttaattgat cttgagaaat tttaccaacc taccagtctt   240
ctgattggac tgggtagcct aaaactaaac gatcaagcac gcactgcttg gcgaaactat   300
gataaattcc attacgatca tgtcaaacac gtactaagtc tctatggacc tgtttttgaa   360
ttt                                                                 363

<210>   2582
<211>   121
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903202 (2.E-29)

<400>   2582
Met Leu Tyr Tyr Arg Glu Arg Val His Gln Ile Lys Glu Asp Ala His 
1               5                   10                  15      

Met Glu Asp Lys Lys Leu Ile Gln Leu Leu Ser Lys Leu Asn Lys Ser 
            20                  25                  30          

Tyr Gln Asn Cys Lys Gln Gly Thr Ala Asp Asp Ile Arg Leu Gln Glu 
        35                  40                  45              

Leu Leu Asn Thr Thr Met Gln Glu Leu Lys Lys Thr Glu Gln Leu Asn 
    50                  55                  60                  

Asn Ser Ile Leu Ile Asp Leu Glu Lys Phe Tyr Gln Pro Thr Ser Leu 
65                  70                  75                  80  

Leu Ile Gly Leu Gly Ser Leu Lys Leu Asn Asp Gln Ala Arg Thr Ala 
                85                  90                  95      

Trp Arg Asn Tyr Asp Lys Phe His Tyr Asp His Val Lys His Val Leu 
            100                 105                 110         

Ser Leu Tyr Gly Pro Val Phe Glu Phe 
        115                 120     

<210>   2583
<211>   1557
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2583
atgcactatg aacattctag aaagggaaat catatgataa aaatcaatca tctaaccatc   60
acacaaaaca aagatttacg agatcttgta tctgacctaa ccatgaccat ccaagacggg   120
gaaaaggttg ctattattgg tgaagaagga aatggcaaat caaccttact taaaatttta   180
atgggggaag ctttgtctga tttcactatc aagggaaaca tccaatctga ctatcagtca   240
ctggcctaca ttcctcaaaa agtccctgag gacctaaaaa agaaaacttt acacgactac   300
ttctttttag attctattga tttagactac agtatcctct atcgtttggc ggaggaattg   360
cattttgata gcaatcgttt cgcaagtgac caagagattg gcaatctatc agggggcgaa   420
gctttgaaaa ttcagcttat ccatgagtta gccaaaccct ttgagattct atttttagat   480
gaaccttcaa atgacctaga ccttgagaca gttgattggc taaaaggcca gattcaaaag   540
accaggcaaa ccgttatttt catttcccat gatgaagact ttctttctga aacggcagac   600
actattgttc acttgcgact ggtcaaacac cgtaaagaag cggaaacgct agtagagcat   660
ttagactatg atagctatag tgagcagaga aaggctaatt ttgccaaaca aagtcagcaa   720
gctgctaaca accaaagagc ctacgataaa accatggaaa aacatcggag agttaagcaa   780
aatgtagaaa ctgcgcttcg agctaccaaa gatagtactg ccggtcgcct attggctaaa   840
aagatgaaaa ctgtcctctc acaagaaaaa cgctacgaaa aggcagctca gtccatgact   900
caaaagccac ttgaagagga acaaatccaa cttttctttt cagacatcca accattacca   960
gcttctaaag tcttagtcca actggaaaaa gaaaatttgt ccattgacga ccgagttttg   1020
gttcaaaaac tacaactaac tgtccgtggc caagaaaaaa tcggtattat cgggccaaat   1080
ggtgttggga aatcaactct gttagccaag ttacagagac ttctgaatga taaaagagag   1140
atttcacttg gttttatgcc acaagattac cacaaaaaac tgcaattgga tttatcccca   1200
atagcctatc tcagtaaaac tggggaaaaa gaggaactac agaaaatcca atctcaccta   1260
gctagtctca atttcagtta tccagaaatg cagcatcaaa ttcgctcctt atctggcgga   1320
caacagggaa aactcctgct tttggattta gtcctgcgca aaccaaactt tctcctgctg   1380
gatgaaccca cacgaaactt ttctcccact tctcaacccc aaatcagaaa actctttgct   1440
acctatccag gcggtctcat cactgtttcg catgaccgtc gtttcttaaa agaagtctgc   1500
tcgatcatct atcgcatgac agaacacggt ttgaagctag ttaatttaga agattta      1557

<210>   2584
<211>   519
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903204 (0.E+01)

<400>   2584
Met His Tyr Glu His Ser Arg Lys Gly Asn His Met Ile Lys Ile Asn 
1               5                   10                  15      

His Leu Thr Ile Thr Gln Asn Lys Asp Leu Arg Asp Leu Val Ser Asp 
            20                  25                  30          

Leu Thr Met Thr Ile Gln Asp Gly Glu Lys Val Ala Ile Ile Gly Glu 
        35                  40                  45              

Glu Gly Asn Gly Lys Ser Thr Leu Leu Lys Ile Leu Met Gly Glu Ala 
    50                  55                  60                  

Leu Ser Asp Phe Thr Ile Lys Gly Asn Ile Gln Ser Asp Tyr Gln Ser 

65                  70                  75                  80  

Leu Ala Tyr Ile Pro Gln Lys Val Pro Glu Asp Leu Lys Lys Lys Thr 
                85                  90                  95      

Leu His Asp Tyr Phe Phe Leu Asp Ser Ile Asp Leu Asp Tyr Ser Ile 
            100                 105                 110         

Leu Tyr Arg Leu Ala Glu Glu Leu His Phe Asp Ser Asn Arg Phe Ala 
        115                 120                 125             

Ser Asp Gln Glu Ile Gly Asn Leu Ser Gly Gly Glu Ala Leu Lys Ile 
    130                 135                 140                 

Gln Leu Ile His Glu Leu Ala Lys Pro Phe Glu Ile Leu Phe Leu Asp 
145                 150                 155                 160 

Glu Pro Ser Asn Asp Leu Asp Leu Glu Thr Val Asp Trp Leu Lys Gly 
                165                 170                 175     

Gln Ile Gln Lys Thr Arg Gln Thr Val Ile Phe Ile Ser His Asp Glu 
            180                 185                 190         

Asp Phe Leu Ser Glu Thr Ala Asp Thr Ile Val His Leu Arg Leu Val 
        195                 200                 205             

Lys His Arg Lys Glu Ala Glu Thr Leu Val Glu His Leu Asp Tyr Asp 
    210                 215                 220                 

Ser Tyr Ser Glu Gln Arg Lys Ala Asn Phe Ala Lys Gln Ser Gln Gln 
225                 230                 235                 240 

Ala Ala Asn Asn Gln Arg Ala Tyr Asp Lys Thr Met Glu Lys His Arg 
                245                 250                 255     

Arg Val Lys Gln Asn Val Glu Thr Ala Leu Arg Ala Thr Lys Asp Ser 
            260                 265                 270         

Thr Ala Gly Arg Leu Leu Ala Lys Lys Met Lys Thr Val Leu Ser Gln 
        275                 280                 285             

Glu Lys Arg Tyr Glu Lys Ala Ala Gln Ser Met Thr Gln Lys Pro Leu 
    290                 295                 300                 

Glu Glu Glu Gln Ile Gln Leu Phe Phe Ser Asp Ile Gln Pro Leu Pro 
305                 310                 315                 320 

Ala Ser Lys Val Leu Val Gln Leu Glu Lys Glu Asn Leu Ser Ile Asp 
                325                 330                 335     

Asp Arg Val Leu Val Gln Lys Leu Gln Leu Thr Val Arg Gly Gln Glu 
            340                 345                 350         

Lys Ile Gly Ile Ile Gly Pro Asn Gly Val Gly Lys Ser Thr Leu Leu 
        355                 360                 365             

Ala Lys Leu Gln Arg Leu Leu Asn Asp Lys Arg Glu Ile Ser Leu Gly 
    370                 375                 380                 

Phe Met Pro Gln Asp Tyr His Lys Lys Leu Gln Leu Asp Leu Ser Pro 
385                 390                 395                 400 

Ile Ala Tyr Leu Ser Lys Thr Gly Glu Lys Glu Glu Leu Gln Lys Ile 
                405                 410                 415     

Gln Ser His Leu Ala Ser Leu Asn Phe Ser Tyr Pro Glu Met Gln His 
            420                 425                 430         

Gln Ile Arg Ser Leu Ser Gly Gly Gln Gln Gly Lys Leu Leu Leu Leu 
        435                 440                 445             

Asp Leu Val Leu Arg Lys Pro Asn Phe Leu Leu Leu Asp Glu Pro Thr 
    450                 455                 460                 

Arg Asn Phe Ser Pro Thr Ser Gln Pro Gln Ile Arg Lys Leu Phe Ala 
465                 470                 475                 480 

Thr Tyr Pro Gly Gly Leu Ile Thr Val Ser His Asp Arg Arg Phe Leu 
                485                 490                 495     

Lys Glu Val Cys Ser Ile Ile Tyr Arg Met Thr Glu His Gly Leu Lys 
            500                 505                 510         

Leu Val Asn Leu Glu Asp Leu 
        515                 

<210>   2585
<211>   906
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2585
gtgactaaga tgttgtttga tcaaattgca agcaataaac gaaaaacctg gattttgttg   60
ctggtatttt tcctactctt agctcttgtt ggttatgcgg ttggttatct ctttataaga   120
tctggacttg gtggtttggt tattgcactg attatcggct ttatctacgc tttgtctatg   180
atttttcaat cgacagagat tgtcatgtcc atgaatggag cgcgtgaggt ggatgagcaa   240
acggcaccag acctctacca tgtagtggaa gatatggctc tggtcgctca gattcctatg   300
ccccgtgttt tcatcattga tgatccagcc ttaaatgcct ttgcgacagg ttctaatcct   360
caaaatgcgg ctgttgctgc gacttcaggt ctactagcta tcatgaatcg tgaagaacta   420
gaagctgtta tgggacatga agtcagtcat attcgtaatt atgatatccg tatttcgact   480
attgcagttg cccttgctag tgctatcacc atgctttcta gtatggcagg tcgtatgatg   540
tggtggggtg gagcaggtcg cagacgaagt gatgatgacc gagatggaaa tggtcttgaa   600
atcattatgc tagtggtttc cctactagct attgtactgg cacctctcgc tgcaaccttg   660
gttcagctcg ctatttctcg tcagagggaa tttctggcag atgcatctag tgtcgagctg   720
actcgcaatc cccagggaat gattaatgcc ctagataagt tggacaatag caaacctatg   780
agtcgccacg tcgatgatgc tagcagtgcc ctttatatca atgatcctaa gaaaggtggg   840
gggttccaaa aactctttta tacccaccca cctatctcag aacggattga acgtttaaaa   900
cagatg                                                              906

<210>   2586
<211>   302
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   heat shock protein HtpX (htpX)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903205 (e-165)

<400>   2586
Met Thr Lys Met Leu Phe Asp Gln Ile Ala Ser Asn Lys Arg Lys Thr 
1               5                   10                  15      

Trp Ile Leu Leu Leu Val Phe Phe Leu Leu Leu Ala Leu Val Gly Tyr 
            20                  25                  30          

Ala Val Gly Tyr Leu Phe Ile Arg Ser Gly Leu Gly Gly Leu Val Ile 
        35                  40                  45              

Ala Leu Ile Ile Gly Phe Ile Tyr Ala Leu Ser Met Ile Phe Gln Ser 
    50                  55                  60                  

Thr Glu Ile Val Met Ser Met Asn Gly Ala Arg Glu Val Asp Glu Gln 
65                  70                  75                  80  

Thr Ala Pro Asp Leu Tyr His Val Val Glu Asp Met Ala Leu Val Ala 
                85                  90                  95      

Gln Ile Pro Met Pro Arg Val Phe Ile Ile Asp Asp Pro Ala Leu Asn 
            100                 105                 110         

Ala Phe Ala Thr Gly Ser Asn Pro Gln Asn Ala Ala Val Ala Ala Thr 
        115                 120                 125             

Ser Gly Leu Leu Ala Ile Met Asn Arg Glu Glu Leu Glu Ala Val Met 
    130                 135                 140                 

Gly His Glu Val Ser His Ile Arg Asn Tyr Asp Ile Arg Ile Ser Thr 
145                 150                 155                 160 

Ile Ala Val Ala Leu Ala Ser Ala Ile Thr Met Leu Ser Ser Met Ala 
                165                 170                 175     

Gly Arg Met Met Trp Trp Gly Gly Ala Gly Arg Arg Arg Ser Asp Asp 
            180                 185                 190         

Asp Arg Asp Gly Asn Gly Leu Glu Ile Ile Met Leu Val Val Ser Leu 
        195                 200                 205             

Leu Ala Ile Val Leu Ala Pro Leu Ala Ala Thr Leu Val Gln Leu Ala 
    210                 215                 220                 

Ile Ser Arg Gln Arg Glu Phe Leu Ala Asp Ala Ser Ser Val Glu Leu 
225                 230                 235                 240 

Thr Arg Asn Pro Gln Gly Met Ile Asn Ala Leu Asp Lys Leu Asp Asn 
                245                 250                 255     

Ser Lys Pro Met Ser Arg His Val Asp Asp Ala Ser Ser Ala Leu Tyr 
            260                 265                 270         


Ile Asn Asp Pro Lys Lys Gly Gly Gly Phe Gln Lys Leu Phe Tyr Thr 
        275                 280                 285             

His Pro Pro Ile Ser Glu Arg Ile Glu Arg Leu Lys Gln Met 
    290                 295                 300         

<210>   2587
<211>   558
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2587
atgacttgga ttattcttgg agttatcgct cttattgtta tttttgtgat tgttagctat   60
aacggtttgg ttaaaaatcg tatgcaaacc aaggaggctt ggagtcagat tgatgttcag   120
ttgaaacgtc gcaatgacct cttgccaaac ttgattgaga ctgtaaaagg ttatgccaaa   180
tatgaaggtt ctacccttga aaaggtggca gaactacgta accaagtggc ggcagcgact   240
tcaccagcag aagctatgaa agccagtgat gccctcactc gtcaggtttc aggtattttt   300
gcagttgcag aaagctatcc agatttgaaa gctagtgcta actttgttaa attgcaagag   360
gagttgacaa acacagaaaa taaaatttct tactctcgtc aactctataa cagtgttgtc   420
agcaactaca atgtaaaatt agaaactttc ccgagcaata ttatcgctgg aatgtttgga   480
tttaaagcgg cagatttcct tcaaacacct gaagaggaaa agtcggttcc taaagttgat   540
tttagcggtt taggtgac                                                 558

<210>   2588
<211>   186
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lemA protein (lemA)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903206 (e-101)

<400>   2588
Met Thr Trp Ile Ile Leu Gly Val Ile Ala Leu Ile Val Ile Phe Val 
1               5                   10                  15      

Ile Val Ser Tyr Asn Gly Leu Val Lys Asn Arg Met Gln Thr Lys Glu 
            20                  25                  30          

Ala Trp Ser Gln Ile Asp Val Gln Leu Lys Arg Arg Asn Asp Leu Leu 
        35                  40                  45              

Pro Asn Leu Ile Glu Thr Val Lys Gly Tyr Ala Lys Tyr Glu Gly Ser 
    50                  55                  60                  

Thr Leu Glu Lys Val Ala Glu Leu Arg Asn Gln Val Ala Ala Ala Thr 
65                  70                  75                  80  

Ser Pro Ala Glu Ala Met Lys Ala Ser Asp Ala Leu Thr Arg Gln Val 
                85                  90                  95      

Ser Gly Ile Phe Ala Val Ala Glu Ser Tyr Pro Asp Leu Lys Ala Ser 
            100                 105                 110         

Ala Asn Phe Val Lys Leu Gln Glu Glu Leu Thr Asn Thr Glu Asn Lys 
        115                 120                 125             

Ile Ser Tyr Ser Arg Gln Leu Tyr Asn Ser Val Val Ser Asn Tyr Asn 
    130                 135                 140                 

Val Lys Leu Glu Thr Phe Pro Ser Asn Ile Ile Ala Gly Met Phe Gly 
145                 150                 155                 160 

Phe Lys Ala Ala Asp Phe Leu Gln Thr Pro Glu Glu Glu Lys Ser Val 
                165                 170                 175     

Pro Lys Val Asp Phe Ser Gly Leu Gly Asp 
            180                 185     

<210>   2589
<211>   735
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2589
atgatactaa agaaggaaat aactatgaaa ccaaaaacat tttacaactt gcttgccgag   60
cagaatcttc cactttcgga ccagcaaaaa gaacaatttg aacgttattt tgagctcttg   120
gtcgagtgga atgagaagat taatttgacg gcgattacgg acaaggaaga agtttatctc   180
aaacattttt acgattcgat tgcacccatt cttcaaggtt tgattcccaa tgaaactatc   240
aaacttcttg atatcggggc tggggcagga tttcctagtc taccaatgaa aattctctat   300
ccggagttag atgtgaccat tattgattca ctcaataagc gcatcaactt cctacaactc   360
ttggctcaag aactggattt gaacggagtt catttctacc acggacgtgc cgaagatttt   420
gcccaagaca agaacttccg tgctcaatat gattttgtaa cagctcgtgc ggttgcccgt   480
atgcaggtcc tatctgaatt gactattccc taccttaagg ttggtggcaa actattagca   540
ctcaaggcta gcaatgcgcc tgaggaatta ttagaagcta agaatgccct caatctcctt   600
tttagtaagg tcgaagacaa tctcagctac gccctaccga atagagatcc gcgctatatc   660
acagtggtag aaaagaaaaa agaaacacca aataaatatc cacgtaaggc tggtatgcca   720
aataaacgcc cactt                                                    735

<210>   2590
<211>   245
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucose-inhibited division protein B (gidB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903207 (e-134)

<400>   2590
Met Ile Leu Lys Lys Glu Ile Thr Met Lys Pro Lys Thr Phe Tyr Asn 
1               5                   10                  15      

Leu Leu Ala Glu Gln Asn Leu Pro Leu Ser Asp Gln Gln Lys Glu Gln 
            20                  25                  30          

Phe Glu Arg Tyr Phe Glu Leu Leu Val Glu Trp Asn Glu Lys Ile Asn 
        35                  40                  45              

Leu Thr Ala Ile Thr Asp Lys Glu Glu Val Tyr Leu Lys His Phe Tyr 
    50                  55                  60                  

Asp Ser Ile Ala Pro Ile Leu Gln Gly Leu Ile Pro Asn Glu Thr Ile 
65                  70                  75                  80  

Lys Leu Leu Asp Ile Gly Ala Gly Ala Gly Phe Pro Ser Leu Pro Met 
                85                  90                  95      

Lys Ile Leu Tyr Pro Glu Leu Asp Val Thr Ile Ile Asp Ser Leu Asn 
            100                 105                 110         

Lys Arg Ile Asn Phe Leu Gln Leu Leu Ala Gln Glu Leu Asp Leu Asn 
        115                 120                 125             

Gly Val His Phe Tyr His Gly Arg Ala Glu Asp Phe Ala Gln Asp Lys 
    130                 135                 140                 

Asn Phe Arg Ala Gln Tyr Asp Phe Val Thr Ala Arg Ala Val Ala Arg 
145                 150                 155                 160 

Met Gln Val Leu Ser Glu Leu Thr Ile Pro Tyr Leu Lys Val Gly Gly 
                165                 170                 175     

Lys Leu Leu Ala Leu Lys Ala Ser Asn Ala Pro Glu Glu Leu Leu Glu 
            180                 185                 190         

Ala Lys Asn Ala Leu Asn Leu Leu Phe Ser Lys Val Glu Asp Asn Leu 
        195                 200                 205             

Ser Tyr Ala Leu Pro Asn Arg Asp Pro Arg Tyr Ile Thr Val Val Glu 
    210                 215                 220                 

Lys Lys Lys Glu Thr Pro Asn Lys Tyr Pro Arg Lys Ala Gly Met Pro 
225                 230                 235                 240 

Asn Lys Arg Pro Leu 
                245 

<210>   2591
<211>   1317
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2591
atgggctctt ttttgatgcc caaaagtgag gtttatatga aacaagaatc aactgttgat   60
ttgttactag acgttgacca acgtccttcg gctggaaaag gaattctcct tagtttccaa   120
cacgttttcg ccatgtttgg tgcgaccatc ttggtaccat tgattttggg aatgcctgta   180
tctgttgccc tttttgcttc aggtgttgga acactcatct acatgattgc tactggtttt   240
aaagttccag tttatctagg ttcttcattt gcctttatca cagctatgtc actggctatg   300
aaagaaatgg ggggggatgt atctgctgcc caaacagggg ttatcttgac tggtttggtc   360
tatgtccttg ttgctaccag catccgattt gtaggaacaa aatggattga taaactcttg   420
ccaccaatca ttatcggtcc tatgatcatc gttatcggtc ttggacttgc aggttcagct   480
gttaccaatg caggtcttgt agcagacgga aattggaaaa atgctctggt agccgttgtt   540
actttcctaa ttgctgcctt tatcaataca aaaggaaaag gcttcctacg aatcattcca   600
ttcctctttg ccattatcgg tggttacctt ttcgcactaa ctcttggctt ggttgacttt   660
acaccagttc ttaaagccaa ctggttcgaa attcctggtt tctacttgcc atttagcaca   720
ggtggtgcct ttaaagagta caatctttac tttggtccag aagccatcgc tatcttgcca   780
atcgctatcg taacaatttc tgaacatatc ggagaccata ctgttttggg tcaaatctgt   840
ggtcgtcaat tcttaaaaga accaggtctt caccgtactc ttcttggtga cggtatcgca   900
acttctgttt ctgccttcct tggtggacca gccaatacaa cttacggaga aaatacaggg   960
gttatcggta tgactcgtat cgcttctgtc tcagttatcc gtaacgctgc cttcatcgcg   1020
attgccctca gcttccttgg taaattcact gccttgattt caactattcc aaacgctgta   1080
cttggtggta tgtcaatcct tctctatggg gttatcgcca gcaatggttt gaaagtcttg   1140
attaaagaac gtgttgattt cgctcaaatg cgaaacctca tcatcgcaag tgctatgttg   1200
gttcttggac ttggaggagc tatccttaaa cttggtccag ttacactttc aggtactgcc   1260
ctttcagcca tgacaggaat catcttgaac ttgatcttgc catacgaaaa taaagac      1317

<210>   2592
<211>   439
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   uracil permease (uraA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903208 (0.E+01)

<400>   2592
Met Gly Ser Phe Leu Met Pro Lys Ser Glu Val Tyr Met Lys Gln Glu 
1               5                   10                  15      

Ser Thr Val Asp Leu Leu Leu Asp Val Asp Gln Arg Pro Ser Ala Gly 
            20                  25                  30          

Lys Gly Ile Leu Leu Ser Phe Gln His Val Phe Ala Met Phe Gly Ala 
        35                  40                  45              

Thr Ile Leu Val Pro Leu Ile Leu Gly Met Pro Val Ser Val Ala Leu 
    50                  55                  60                  

Phe Ala Ser Gly Val Gly Thr Leu Ile Tyr Met Ile Ala Thr Gly Phe 
65                  70                  75                  80  

Lys Val Pro Val Tyr Leu Gly Ser Ser Phe Ala Phe Ile Thr Ala Met 
                85                  90                  95      

Ser Leu Ala Met Lys Glu Met Gly Gly Asp Val Ser Ala Ala Gln Thr 
            100                 105                 110         

Gly Val Ile Leu Thr Gly Leu Val Tyr Val Leu Val Ala Thr Ser Ile 
        115                 120                 125             

Arg Phe Val Gly Thr Lys Trp Ile Asp Lys Leu Leu Pro Pro Ile Ile 
    130                 135                 140                 

Ile Gly Pro Met Ile Ile Val Ile Gly Leu Gly Leu Ala Gly Ser Ala 
145                 150                 155                 160 

Val Thr Asn Ala Gly Leu Val Ala Asp Gly Asn Trp Lys Asn Ala Leu 
                165                 170                 175     

Val Ala Val Val Thr Phe Leu Ile Ala Ala Phe Ile Asn Thr Lys Gly 
            180                 185                 190         

Lys Gly Phe Leu Arg Ile Ile Pro Phe Leu Phe Ala Ile Ile Gly Gly 
        195                 200                 205             

Tyr Leu Phe Ala Leu Thr Leu Gly Leu Val Asp Phe Thr Pro Val Leu 
    210                 215                 220                 

Lys Ala Asn Trp Phe Glu Ile Pro Gly Phe Tyr Leu Pro Phe Ser Thr 
225                 230                 235                 240 

Gly Gly Ala Phe Lys Glu Tyr Asn Leu Tyr Phe Gly Pro Glu Ala Ile 
                245                 250                 255     

Ala Ile Leu Pro Ile Ala Ile Val Thr Ile Ser Glu His Ile Gly Asp 
            260                 265                 270         

His Thr Val Leu Gly Gln Ile Cys Gly Arg Gln Phe Leu Lys Glu Pro 
        275                 280                 285             

Gly Leu His Arg Thr Leu Leu Gly Asp Gly Ile Ala Thr Ser Val Ser 
    290                 295                 300                 

Ala Phe Leu Gly Gly Pro Ala Asn Thr Thr Tyr Gly Glu Asn Thr Gly 
305                 310                 315                 320 

Val Ile Gly Met Thr Arg Ile Ala Ser Val Ser Val Ile Arg Asn Ala 
                325                 330                 335     

Ala Phe Ile Ala Ile Ala Leu Ser Phe Leu Gly Lys Phe Thr Ala Leu 
            340                 345                 350         

Ile Ser Thr Ile Pro Asn Ala Val Leu Gly Gly Met Ser Ile Leu Leu 
        355                 360                 365             

Tyr Gly Val Ile Ala Ser Asn Gly Leu Lys Val Leu Ile Lys Glu Arg 
    370                 375                 380                 

Val Asp Phe Ala Gln Met Arg Asn Leu Ile Ile Ala Ser Ala Met Leu 
385                 390                 395                 400 

Val Leu Gly Leu Gly Gly Ala Ile Leu Lys Leu Gly Pro Val Thr Leu 
                405                 410                 415     

Ser Gly Thr Ala Leu Ser Ala Met Thr Gly Ile Ile Leu Asn Leu Ile 
            420                 425                 430         

Leu Pro Tyr Glu Asn Lys Asp 
        435                 

<210>   2593
<211>   1569
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2593
atggcatttg aaagtttaac agaacgtttg cagaacgtct ttaaaaatct acgtaaaaaa   60
ggaaaaatct ctgaatctga tgtccaagag gcaaccaaag aaattcgctt ggccttgctc   120
gaggccgacg ttgccttgcc tgttgtaaag gactttatca agaaagttcg tgagcgtgca   180
gtcgggcatg aggtcattga tacacttaat cctgcgcaac agattattaa aatcgttgat   240
gaggaattga cagccgtttt aggttctgat acggcagaaa ttatcaagtc acctaagatt   300
ccaaccatca tcatgatggt tggtttacaa ggggctggta aaacaacctt tgctggtaaa   360
ttggccaaca aactcaagaa agaagaaaat gctcgtcctt tgatgattgc ggcggatatt   420
tatcgtccag ctgccattga ccagcttaag accttgggac aacagattga tgtgcctgtc   480
tttgcacttg gaacagaagt accagctgtt gagattgtac gtcaaggttt ggagcaagcc   540
caaactaatc ataacgacta tgtcttgatt gatactgcgg gtcgtttgca gattgatgag   600
ctcctcatga atgagcttcg tgatgtgaaa gcattggctc aaccaaatga aatcttgctt   660
gtcgttgatg ctatgattgg tcaggaagca gccaatgttg cgcgtgagtt taatgctcag   720
ttggaagtga ctggggtcat ccttaccaag attgatggcg atactcgtgg tggtgctgct   780
ctgtctgttc gtcacattac tggaaaacca atcaagttca ctggtacagg tgaaaagatt   840
acggacattg aaaccttcca cccagaccgc atgtctagcc gtatccttgg tatgggggat   900
atgctcactt tgattgagaa agcttctcag gaatacgatg aacaaaaagc ccttgaaatg   960
gctgagaaga tgcgcgaaaa cacctttgat tttaatgatt tcatcgatca attagatcag   1020
gtgcaaaata tggggccgat ggaagacttg ctcaagatga ttccaggtat ggccaacaat   1080
ccagcccttc aaaacatgaa ggtggatgaa cgccagattg ctcgtaaacg tgccattgtg   1140
tcttcgatga cacctgaaga gcgtgaaaac ccagatttgt taaatccaag ccgtcgccgt   1200
cgtattgctg ctggttctgg aaatacattc gtcgaagtca ataaattcat caaggacttt   1260
aaccaggcta aacagctcat gcagggtgtt atgtctgggg atatgaataa aatgatgaag   1320
caaatgggga ttaatccaaa taaccttcct aaaaatatgc caaatatggg aggaatggat   1380
atgtctgccc ttgaaggaat gatgggacaa ggcggtatgc ctgacttatc agctctcgga   1440
ggagcaggaa tgccagatat gagccagatg tttggtggcg gtttgaaagg taaaattggt   1500
gaatttgcca tgaaacagtc catgaaacgt atggctaaca aaatgaagaa agcgaagaag   1560
aaacgcaag                                                           1569

<210>   2594
<211>   523
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   signal recognition particle protein (ffh)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903209 (0.E+01)

<400>   2594
Met Ala Phe Glu Ser Leu Thr Glu Arg Leu Gln Asn Val Phe Lys Asn 
1               5                   10                  15      

Leu Arg Lys Lys Gly Lys Ile Ser Glu Ser Asp Val Gln Glu Ala Thr 
            20                  25                  30          

Lys Glu Ile Arg Leu Ala Leu Leu Glu Ala Asp Val Ala Leu Pro Val 
        35                  40                  45              

Val Lys Asp Phe Ile Lys Lys Val Arg Glu Arg Ala Val Gly His Glu 
    50                  55                  60                  

Val Ile Asp Thr Leu Asn Pro Ala Gln Gln Ile Ile Lys Ile Val Asp 
65                  70                  75                  80  

Glu Glu Leu Thr Ala Val Leu Gly Ser Asp Thr Ala Glu Ile Ile Lys 
                85                  90                  95      

Ser Pro Lys Ile Pro Thr Ile Ile Met Met Val Gly Leu Gln Gly Ala 
            100                 105                 110         

Gly Lys Thr Thr Phe Ala Gly Lys Leu Ala Asn Lys Leu Lys Lys Glu 
        115                 120                 125             

Glu Asn Ala Arg Pro Leu Met Ile Ala Ala Asp Ile Tyr Arg Pro Ala 
    130                 135                 140                 

Ala Ile Asp Gln Leu Lys Thr Leu Gly Gln Gln Ile Asp Val Pro Val 
145                 150                 155                 160 

Phe Ala Leu Gly Thr Glu Val Pro Ala Val Glu Ile Val Arg Gln Gly 
                165                 170                 175     

Leu Glu Gln Ala Gln Thr Asn His Asn Asp Tyr Val Leu Ile Asp Thr 
            180                 185                 190         

Ala Gly Arg Leu Gln Ile Asp Glu Leu Leu Met Asn Glu Leu Arg Asp 
        195                 200                 205             

Val Lys Ala Leu Ala Gln Pro Asn Glu Ile Leu Leu Val Val Asp Ala 
    210                 215                 220                 

Met Ile Gly Gln Glu Ala Ala Asn Val Ala Arg Glu Phe Asn Ala Gln 
225                 230                 235                 240 

Leu Glu Val Thr Gly Val Ile Leu Thr Lys Ile Asp Gly Asp Thr Arg 
                245                 250                 255     

Gly Gly Ala Ala Leu Ser Val Arg His Ile Thr Gly Lys Pro Ile Lys 
            260                 265                 270         

Phe Thr Gly Thr Gly Glu Lys Ile Thr Asp Ile Glu Thr Phe His Pro 
        275                 280                 285             

Asp Arg Met Ser Ser Arg Ile Leu Gly Met Gly Asp Met Leu Thr Leu 
    290                 295                 300                 

Ile Glu Lys Ala Ser Gln Glu Tyr Asp Glu Gln Lys Ala Leu Glu Met 
305                 310                 315                 320 

Ala Glu Lys Met Arg Glu Asn Thr Phe Asp Phe Asn Asp Phe Ile Asp 
                325                 330                 335     

Gln Leu Asp Gln Val Gln Asn Met Gly Pro Met Glu Asp Leu Leu Lys 
            340                 345                 350         

Met Ile Pro Gly Met Ala Asn Asn Pro Ala Leu Gln Asn Met Lys Val 
        355                 360                 365             

Asp Glu Arg Gln Ile Ala Arg Lys Arg Ala Ile Val Ser Ser Met Thr 

    370                 375                 380                 

Pro Glu Glu Arg Glu Asn Pro Asp Leu Leu Asn Pro Ser Arg Arg Arg 
385                 390                 395                 400 

Arg Ile Ala Ala Gly Ser Gly Asn Thr Phe Val Glu Val Asn Lys Phe 
                405                 410                 415     

Ile Lys Asp Phe Asn Gln Ala Lys Gln Leu Met Gln Gly Val Met Ser 
            420                 425                 430         

Gly Asp Met Asn Lys Met Met Lys Gln Met Gly Ile Asn Pro Asn Asn 
        435                 440                 445             

Leu Pro Lys Asn Met Pro Asn Met Gly Gly Met Asp Met Ser Ala Leu 
    450                 455                 460                 

Glu Gly Met Met Gly Gln Gly Gly Met Pro Asp Leu Ser Ala Leu Gly 
465                 470                 475                 480 

Gly Ala Gly Met Pro Asp Met Ser Gln Met Phe Gly Gly Gly Leu Lys 
                485                 490                 495     

Gly Lys Ile Gly Glu Phe Ala Met Lys Gln Ser Met Lys Arg Met Ala 
            500                 505                 510         

Asn Lys Met Lys Lys Ala Lys Lys Lys Arg Lys 
        515                 520             

<210>   2595
<211>   330
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2595
atggaaatcg aaaaaaccaa tcgtatgaat gcgctctttg aattttatgc ggcgcttttg   60
acagataagc aaatgaatta tatcgagctc tactacgctg atgattacag ccttgctgaa   120
attgccgagg agttcggtgt cagtcgtcag gctgtctatg acaatatcaa gcgaacagaa   180
aagattctgg aagattatga gatgaaattg cacatgtact cggactatat tgtccgcagt   240
cagatttttg atcagatttt ggagcgctat cccaaggatg actttctgca ggagcagata   300
gaaattttaa caagcattga taatagagaa                                    330

<210>   2596
<211>   110
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903210 (6.E-59)

<400>   2596
Met Glu Ile Glu Lys Thr Asn Arg Met Asn Ala Leu Phe Glu Phe Tyr 
1               5                   10                  15      

Ala Ala Leu Leu Thr Asp Lys Gln Met Asn Tyr Ile Glu Leu Tyr Tyr 
            20                  25                  30          

Ala Asp Asp Tyr Ser Leu Ala Glu Ile Ala Glu Glu Phe Gly Val Ser 
        35                  40                  45              


Arg Gln Ala Val Tyr Asp Asn Ile Lys Arg Thr Glu Lys Ile Leu Glu 
    50                  55                  60                  

Asp Tyr Glu Met Lys Leu His Met Tyr Ser Asp Tyr Ile Val Arg Ser 
65                  70                  75                  80  

Gln Ile Phe Asp Gln Ile Leu Glu Arg Tyr Pro Lys Asp Asp Phe Leu 
                85                  90                  95      

Gln Glu Gln Ile Glu Ile Leu Thr Ser Ile Asp Asn Arg Glu 
            100                 105                 110 

<210>   2597
<211>   375
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2597
gtgaagattc ggatgcgaaa tacgattcag tttgatgagc agttggaagt gattgaccag   60
ctttatgatg tggaagtgca tgaaaaagga gattatagct acctgctttt ctataatgag   120
gaaaaggaaa aagtagtgat taaatttcat ggtcaagaac ttgtgatgag ccgattttct   180
aatcccaaga ccattatgcg ctttctaaag gatagcgata gtttagccta tattcctaca   240
cctatgggca tgcaggagtt tatcatccaa acgagccatt atcaagttga taggcaaaag   300
attgaactag attatcaact acaaaatcaa gagggacatc cctttgccag ctatcaattg   360
gaaattactt ggggc                                                    375

<210>   2598
<211>   125
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903211 (2.E-68)

<400>   2598
Met Lys Ile Arg Met Arg Asn Thr Ile Gln Phe Asp Glu Gln Leu Glu 
1               5                   10                  15      

Val Ile Asp Gln Leu Tyr Asp Val Glu Val His Glu Lys Gly Asp Tyr 
            20                  25                  30          

Ser Tyr Leu Leu Phe Tyr Asn Glu Glu Lys Glu Lys Val Val Ile Lys 
        35                  40                  45              

Phe His Gly Gln Glu Leu Val Met Ser Arg Phe Ser Asn Pro Lys Thr 
    50                  55                  60                  

Ile Met Arg Phe Leu Lys Asp Ser Asp Ser Leu Ala Tyr Ile Pro Thr 
65                  70                  75                  80  

Pro Met Gly Met Gln Glu Phe Ile Ile Gln Thr Ser His Tyr Gln Val 
                85                  90                  95      

Asp Arg Gln Lys Ile Glu Leu Asp Tyr Gln Leu Gln Asn Gln Glu Gly 
            100                 105                 110         

His Pro Phe Ala Ser Tyr Gln Leu Glu Ile Thr Trp Gly 
        115                 120                 125 

<210>   2599
<211>   1302
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2599
atgaacgaaa aagtattccg tgaccctgtt cacaactaca tccatgtcaa taatcaaatc   60
atctatgact tgattaatac aaaagaattt cagcgtttgc gccggatcaa acaactggga   120
acttccagtt ataccttcca cggtggagaa cacagtcgct tctctcactg tctaggagtc   180
tatgaaattg cacgacgcat cacagagatt ttcgaagaaa aatatcctga ggaatggaat   240
cctgccgagt ctctcttgac catgaccgct gctctcctac acgaccttgg gcatggtgcc   300
tactcccata cttttgaaca tctctttgat acagaccatg aagccattac tcaggagatt   360
attcaaaatc ctgagacaga gattcaccaa gtcctgctac aagtggcacc tgatttccca   420
gaaaaggtgg ccagtgtcat tgaccatacc tatcctaata agcaggtcgt gcagctcatt   480
tctagtcaga ttgacgcaga tcgcatggac tatctcttgc gcgactccta ttttacagga   540
gcatcctatg gggaatttga cctgactcga atcctccgag tcattcgtcc tatcgaaaat   600
ggtatcgcct ttcagcgcaa tggcatgcac gccatcgaag actacgtcct cagtcgctac   660
cagatgtaca tgcaggttta tttccacccc gcaacacgcg ccatggaagt tctcctacag   720
aatcttctca aacgcgccaa ggaactctat cctgaggaca aggatttctt tgcccgaact   780
tctccacacc tcctgccttt cttcgaaaaa aatgtgacct tgactgacta tctggctctg   840
gatgatggcg tgatgaatac ctacttccag ctttggatga ccagtcctga caagattctt   900
gcagatttat cgcatcgctt tgtcaaccgc aaggtcttta aatccattac cttttcacaa   960
gaggaccaag atcaacttac tagcatgaga aaattggttg aggatatcgg ctttgatccc   1020
gactactaca ctgccattca taagaacttt gacctccctt atgatatcta tcgtcccgaa   1080
tctgaaaacc cacggacaca gattgagatt ttacaaaaaa atggagaact ggccgaactc   1140
tctagcctgt ctcctatcgt ccaatccctt gctggcagtc gccacggaga taatcgcttt   1200
tattttccaa aagaaatgtt ggaccaaaac agcatctttg caagcattac ccagcaattt   1260
ttacacttga ttgagaacga tcattttacc ccaaataaaa ac                      1302

<210>   2600
<211>   434
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903212 (0.E+01)

<400>   2600
Met Asn Glu Lys Val Phe Arg Asp Pro Val His Asn Tyr Ile His Val 
1               5                   10                  15      

Asn Asn Gln Ile Ile Tyr Asp Leu Ile Asn Thr Lys Glu Phe Gln Arg 
            20                  25                  30          

Leu Arg Arg Ile Lys Gln Leu Gly Thr Ser Ser Tyr Thr Phe His Gly 
        35                  40                  45              

Gly Glu His Ser Arg Phe Ser His Cys Leu Gly Val Tyr Glu Ile Ala 
    50                  55                  60                  

Arg Arg Ile Thr Glu Ile Phe Glu Glu Lys Tyr Pro Glu Glu Trp Asn 
65                  70                  75                  80  

Pro Ala Glu Ser Leu Leu Thr Met Thr Ala Ala Leu Leu His Asp Leu 
                85                  90                  95      

Gly His Gly Ala Tyr Ser His Thr Phe Glu His Leu Phe Asp Thr Asp 
            100                 105                 110         

His Glu Ala Ile Thr Gln Glu Ile Ile Gln Asn Pro Glu Thr Glu Ile 
        115                 120                 125             

His Gln Val Leu Leu Gln Val Ala Pro Asp Phe Pro Glu Lys Val Ala 
    130                 135                 140                 

Ser Val Ile Asp His Thr Tyr Pro Asn Lys Gln Val Val Gln Leu Ile 
145                 150                 155                 160 

Ser Ser Gln Ile Asp Ala Asp Arg Met Asp Tyr Leu Leu Arg Asp Ser 
                165                 170                 175     

Tyr Phe Thr Gly Ala Ser Tyr Gly Glu Phe Asp Leu Thr Arg Ile Leu 
            180                 185                 190         

Arg Val Ile Arg Pro Ile Glu Asn Gly Ile Ala Phe Gln Arg Asn Gly 
        195                 200                 205             

Met His Ala Ile Glu Asp Tyr Val Leu Ser Arg Tyr Gln Met Tyr Met 
    210                 215                 220                 

Gln Val Tyr Phe His Pro Ala Thr Arg Ala Met Glu Val Leu Leu Gln 
225                 230                 235                 240 

Asn Leu Leu Lys Arg Ala Lys Glu Leu Tyr Pro Glu Asp Lys Asp Phe 
                245                 250                 255     

Phe Ala Arg Thr Ser Pro His Leu Leu Pro Phe Phe Glu Lys Asn Val 
            260                 265                 270         

Thr Leu Thr Asp Tyr Leu Ala Leu Asp Asp Gly Val Met Asn Thr Tyr 
        275                 280                 285             

Phe Gln Leu Trp Met Thr Ser Pro Asp Lys Ile Leu Ala Asp Leu Ser 
    290                 295                 300                 

His Arg Phe Val Asn Arg Lys Val Phe Lys Ser Ile Thr Phe Ser Gln 
305                 310                 315                 320 

Glu Asp Gln Asp Gln Leu Thr Ser Met Arg Lys Leu Val Glu Asp Ile 
                325                 330                 335     

Gly Phe Asp Pro Asp Tyr Tyr Thr Ala Ile His Lys Asn Phe Asp Leu 
            340                 345                 350         

Pro Tyr Asp Ile Tyr Arg Pro Glu Ser Glu Asn Pro Arg Thr Gln Ile 
        355                 360                 365             

Glu Ile Leu Gln Lys Asn Gly Glu Leu Ala Glu Leu Ser Ser Leu Ser 
    370                 375                 380                 

Pro Ile Val Gln Ser Leu Ala Gly Ser Arg His Gly Asp Asn Arg Phe 

385                 390                 395                 400 

Tyr Phe Pro Lys Glu Met Leu Asp Gln Asn Ser Ile Phe Ala Ser Ile 
                405                 410                 415     

Thr Gln Gln Phe Leu His Leu Ile Glu Asn Asp His Phe Thr Pro Asn 
            420                 425                 430         

Lys Asn 
        

<210>   2601
<211>   804
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2601
atgagtatta aactaattgc cgttgatatc gacggaaccc ttgtcaacag ccaaaaggaa   60
atcactcctg aagttttttc tgccatccaa gatgccaaag aagctggtgt caaagtcgtg   120
attgcaactg gccgccctat cgcaggcgtt gccaaacttc tagacgactt gcagttgaga   180
gacgaggggg actatgtggt aaccttcaac ggtgcccttg tccaagaaac tgctacagga   240
catgagatta tcagcgaatc cttgacttat gaggattatc tagatatgga attcctcagt   300
cgcaagctcg gtgtccacat gcatgccatt accaaggacg gtatctatac tgcaaatcgc   360
aatatcggaa aatacactgt acacgaatca accctcgtca gcatgcctat cttctaccgt   420
acccctgaag aaatggctgg caaagaaatt gttaaatgta tgtttatcga tgaaccagaa   480
attctcgatg ctgcgattga aaaaattcca gcagaatttt acgagcgcta ctccatcaac   540
aaatctgctc ctttctacct cgaactcctt aaaaagaatg tagacaaggg ttcagccatt   600
actcacttgg ctgaaaaact cggattgacc aaagatgaaa ccatggcaat cggtgatgaa   660
gaaaatgacc gtgccatgct ggaagtcgtt ggaaaccccg ttgtcatgga aaatggaaat   720
ccagaaatca aaaaaatcgc caaatacatc accaaaacaa atgacgaatc cggcgttgcc   780
catgccatcc gaacatgggt actg                                          804

<210>   2602
<211>   268
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Cof family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903213 (e-150)

<400>   2602
Met Ser Ile Lys Leu Ile Ala Val Asp Ile Asp Gly Thr Leu Val Asn 
1               5                   10                  15      

Ser Gln Lys Glu Ile Thr Pro Glu Val Phe Ser Ala Ile Gln Asp Ala 
            20                  25                  30          

Lys Glu Ala Gly Val Lys Val Val Ile Ala Thr Gly Arg Pro Ile Ala 
        35                  40                  45              

Gly Val Ala Lys Leu Leu Asp Asp Leu Gln Leu Arg Asp Glu Gly Asp 
    50                  55                  60                  

Tyr Val Val Thr Phe Asn Gly Ala Leu Val Gln Glu Thr Ala Thr Gly 
65                  70                  75                  80  

His Glu Ile Ile Ser Glu Ser Leu Thr Tyr Glu Asp Tyr Leu Asp Met 
                85                  90                  95      

Glu Phe Leu Ser Arg Lys Leu Gly Val His Met His Ala Ile Thr Lys 
            100                 105                 110         

Asp Gly Ile Tyr Thr Ala Asn Arg Asn Ile Gly Lys Tyr Thr Val His 
        115                 120                 125             

Glu Ser Thr Leu Val Ser Met Pro Ile Phe Tyr Arg Thr Pro Glu Glu 
    130                 135                 140                 

Met Ala Gly Lys Glu Ile Val Lys Cys Met Phe Ile Asp Glu Pro Glu 
145                 150                 155                 160 

Ile Leu Asp Ala Ala Ile Glu Lys Ile Pro Ala Glu Phe Tyr Glu Arg 
                165                 170                 175     


Tyr Ser Ile Asn Lys Ser Ala Pro Phe Tyr Leu Glu Leu Leu Lys Lys 
            180                 185                 190         

Asn Val Asp Lys Gly Ser Ala Ile Thr His Leu Ala Glu Lys Leu Gly 
        195                 200                 205             

Leu Thr Lys Asp Glu Thr Met Ala Ile Gly Asp Glu Glu Asn Asp Arg 
    210                 215                 220                 

Ala Met Leu Glu Val Val Gly Asn Pro Val Val Met Glu Asn Gly Asn 
225                 230                 235                 240 

Pro Glu Ile Lys Lys Ile Ala Lys Tyr Ile Thr Lys Thr Asn Asp Glu 
                245                 250                 255     

Ser Gly Val Ala His Ala Ile Arg Thr Trp Val Leu 
            260                 265             

<210>   2603
<211>   996
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2603
atgaattttt ttagcaaact atttaattta aaacaaaata atcataatag agacacaaat   60
tctgattgta acaattttta cctaaacgaa ttagaatgtg gccttactcc tgggcaactc   120
atactcatag attggactca aaaaacaggg agaaattata atttcccaag atattttaaa   180
tactctcttc aaattgaccc tgaatctaca cacaatcaat tatacaaatt aggatacttc   240
actaaaaata agactttatc atatcttaca gtagtagaat taaaaactat attatctaaa   300
cataatttag ctacttctgg aaaaaaagca gaattaatta caagaataat taataatgtt   360
aacattgaca atttagatat tccgttcgaa tttaaactaa caaaagaagc acaaaatctt   420
attatcgaac atagtgacta tatcaaagca tactatgata aagacataac tatggaagat   480
tattgtaaag aaaaaaacaa tatctctttt aaagcaactt ttggtgatat aaaatggagt   540
ctcttaaata aacaagctca taggaatact gtatcaggag attttggatg cttatctaac   600
acacgaaagg ctcagggaag acatttggaa caagaaggta atattaaaca tgctttaata   660
tattacatag aatctttgat aattactatt tcaggattag aaaacaattt ttcagccact   720
gattatccag tatattatcc cgattcgata cctgactact cactaaaaca tattcaaaca   780
ttaatggaat cattatctga tgacgattat gattttgctt ttgatgaagc attatttcgc   840
ttctcaattt tgaatgcaaa tcatttttta tctaaggaag atattgacta tttaagagtt   900
aatttacctc gttccactgc tgaagaaata aacaattact taaagaaata tgaatgttat   960
agtcctttaa ataatttaga acttgacgat tttgaa                             996

<210>   2604
<211>   332
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SAP domain protein
<223>   Cellular location: cytoplasm

<400>   2604
Met Asn Phe Phe Ser Lys Leu Phe Asn Leu Lys Gln Asn Asn His Asn 
1               5                   10                  15      

Arg Asp Thr Asn Ser Asp Cys Asn Asn Phe Tyr Leu Asn Glu Leu Glu 
            20                  25                  30          

Cys Gly Leu Thr Pro Gly Gln Leu Ile Leu Ile Asp Trp Thr Gln Lys 
        35                  40                  45              

Thr Gly Arg Asn Tyr Asn Phe Pro Arg Tyr Phe Lys Tyr Ser Leu Gln 
    50                  55                  60                  

Ile Asp Pro Glu Ser Thr His Asn Gln Leu Tyr Lys Leu Gly Tyr Phe 
65                  70                  75                  80  

Thr Lys Asn Lys Thr Leu Ser Tyr Leu Thr Val Val Glu Leu Lys Thr 
                85                  90                  95      

Ile Leu Ser Lys His Asn Leu Ala Thr Ser Gly Lys Lys Ala Glu Leu 
            100                 105                 110         

Ile Thr Arg Ile Ile Asn Asn Val Asn Ile Asp Asn Leu Asp Ile Pro 
        115                 120                 125             

Phe Glu Phe Lys Leu Thr Lys Glu Ala Gln Asn Leu Ile Ile Glu His 
    130                 135                 140                 

Ser Asp Tyr Ile Lys Ala Tyr Tyr Asp Lys Asp Ile Thr Met Glu Asp 
145                 150                 155                 160 

Tyr Cys Lys Glu Lys Asn Asn Ile Ser Phe Lys Ala Thr Phe Gly Asp 
                165                 170                 175     

Ile Lys Trp Ser Leu Leu Asn Lys Gln Ala His Arg Asn Thr Val Ser 
            180                 185                 190         

Gly Asp Phe Gly Cys Leu Ser Asn Thr Arg Lys Ala Gln Gly Arg His 
        195                 200                 205             

Leu Glu Gln Glu Gly Asn Ile Lys His Ala Leu Ile Tyr Tyr Ile Glu 
    210                 215                 220                 

Ser Leu Ile Ile Thr Ile Ser Gly Leu Glu Asn Asn Phe Ser Ala Thr 
225                 230                 235                 240 

Asp Tyr Pro Val Tyr Tyr Pro Asp Ser Ile Pro Asp Tyr Ser Leu Lys 
                245                 250                 255     

His Ile Gln Thr Leu Met Glu Ser Leu Ser Asp Asp Asp Tyr Asp Phe 
            260                 265                 270         

Ala Phe Asp Glu Ala Leu Phe Arg Phe Ser Ile Leu Asn Ala Asn His 
        275                 280                 285             

Phe Leu Ser Lys Glu Asp Ile Asp Tyr Leu Arg Val Asn Leu Pro Arg 
    290                 295                 300                 

Ser Thr Ala Glu Glu Ile Asn Asn Tyr Leu Lys Lys Tyr Glu Cys Tyr 
305                 310                 315                 320 

Ser Pro Leu Asn Asn Leu Glu Leu Asp Asp Phe Glu 
                325                 330         

<210>   2605
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2605
atgaatccat taatccaaag cttgactgaa ggtcaacttc gtacagatat cccatcattc   60
cgtcctggtg acactgttcg tgtacatgcg aaagttgtcg aaggtaaccg tgaacgtatc   120
cagatttttg aaggtgttgt tatcgcacgt aaaggtgctg gaatctcaga aaactacaca   180
gttcgtaaaa tctctaacgg tgtaggtgtt gagcgtatct tcccaatcca cactccacgt   240
gttgaaaaaa tcgaagttgt tcgttacggt aaagtacgtc gtgcgaaatt gtactacttg   300
cgtgctcttc aaggtaaagc agctcgtatc aaagaaatcc gtcgt                   345

<210>   2606
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L19 (rplS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903214 (3.E-61)

<400>   2606
Met Asn Pro Leu Ile Gln Ser Leu Thr Glu Gly Gln Leu Arg Thr Asp 
1               5                   10                  15      

Ile Pro Ser Phe Arg Pro Gly Asp Thr Val Arg Val His Ala Lys Val 
            20                  25                  30          

Val Glu Gly Asn Arg Glu Arg Ile Gln Ile Phe Glu Gly Val Val Ile 
        35                  40                  45              

Ala Arg Lys Gly Ala Gly Ile Ser Glu Asn Tyr Thr Val Arg Lys Ile 
    50                  55                  60                  

Ser Asn Gly Val Gly Val Glu Arg Ile Phe Pro Ile His Thr Pro Arg 
65                  70                  75                  80  

Val Glu Lys Ile Glu Val Val Arg Tyr Gly Lys Val Arg Arg Ala Lys 
                85                  90                  95      

Leu Tyr Tyr Leu Arg Ala Leu Gln Gly Lys Ala Ala Arg Ile Lys Glu 
            100                 105                 110         

Ile Arg Arg 
        115 

<210>   2607
<211>   327
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2607
atggtaatcg tctatcttgc aatcgcctgt ggcttgggag cactcgtacg gtatttcttt   60
tctcgctata atcaagcttc taaattgcca ctcggaacgc tcatagctaa tcttttaggt   120
tgttttttaa ttggagtatt ctacaatcat gtagagtcta aggaagtata tgctattcta   180
gcaacaggat tttgtggcgg tttaacaact ttttcgacct tgaatgacga acttcaaaga   240
ctgctaagtg ataagaaggt cttttattct tacctgactt tgacttacat aggtggtttg   300
gttgcgattt ttttaggaat tttgcta                                       327

<210>   2608
<211>   109
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   crcB protein (crcB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903215 (4.E-57)

<400>   2608
Met Val Ile Val Tyr Leu Ala Ile Ala Cys Gly Leu Gly Ala Leu Val 
1               5                   10                  15      

Arg Tyr Phe Phe Ser Arg Tyr Asn Gln Ala Ser Lys Leu Pro Leu Gly 
            20                  25                  30          

Thr Leu Ile Ala Asn Leu Leu Gly Cys Phe Leu Ile Gly Val Phe Tyr 
        35                  40                  45              

Asn His Val Glu Ser Lys Glu Val Tyr Ala Ile Leu Ala Thr Gly Phe 
    50                  55                  60                  

Cys Gly Gly Leu Thr Thr Phe Ser Thr Leu Asn Asp Glu Leu Gln Arg 
65                  70                  75                  80  

Leu Leu Ser Asp Lys Lys Val Phe Tyr Ser Tyr Leu Thr Leu Thr Tyr 
                85                  90                  95      

Ile Gly Gly Leu Val Ala Ile Phe Leu Gly Ile Leu Leu 
            100                 105                 

<210>   2609
<211>   372
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2609
atgaaaaaag aacaatttta tccgctagga atttttctag ctgctatgtt gggcggactt   60
gtccgatatc tagtttccac ctggttacca gccagtccag atttcccttg gggcactctc   120
tttgtcaact atctgggaat tttctgcttg atttatcttg tcaagggcta tctggtctat   180
aaggggacta gtaagggctt gattttagca ctggggacgg gtttttgcgg aggtttaaca   240
actttttcca gcctaatgct tgatactgtg aagctgcttg atacagggcg ttatcttagt   300
ttgatactgt atttgctttt gagtatcggt ggaggcctgc ttttagctta ctatttgggg   360
aggaagaaat gg                                                       372

<210>   2610
<211>   124
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   crcB protein (crcB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903216 (4.E-68)

<400>   2610
Met Lys Lys Glu Gln Phe Tyr Pro Leu Gly Ile Phe Leu Ala Ala Met 
1               5                   10                  15      

Leu Gly Gly Leu Val Arg Tyr Leu Val Ser Thr Trp Leu Pro Ala Ser 
            20                  25                  30          


Pro Asp Phe Pro Trp Gly Thr Leu Phe Val Asn Tyr Leu Gly Ile Phe 
        35                  40                  45              

Cys Leu Ile Tyr Leu Val Lys Gly Tyr Leu Val Tyr Lys Gly Thr Ser 
    50                  55                  60                  

Lys Gly Leu Ile Leu Ala Leu Gly Thr Gly Phe Cys Gly Gly Leu Thr 
65                  70                  75                  80  

Thr Phe Ser Ser Leu Met Leu Asp Thr Val Lys Leu Leu Asp Thr Gly 
                85                  90                  95      

Arg Tyr Leu Ser Leu Ile Leu Tyr Leu Leu Leu Ser Ile Gly Gly Gly 
            100                 105                 110         

Leu Leu Leu Ala Tyr Tyr Leu Gly Arg Lys Lys Trp 
        115                 120                 

<210>   2611
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2611
atggatttag atattattcg tcaagaaatc gatcaaatcg acgaccaaat tgtcaaactg   60
ttagaagaac gaatgcattt agttgagggg gtggttgctt ataagaaagc ttcaggtaaa   120
ccgattttag atactaagag agaagaagtt atttttgaaa aggttaggag tcgtgtagag   180
gacaagcgct atcaggagac tattgtcgcg actttttcgg acatactcaa acgttcgcgt   240
gattatcagg atcaaaatat caaa                                          264

<210>   2612
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   chorismate mutase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903217 (4.E-45)

<400>   2612
Met Asp Leu Asp Ile Ile Arg Gln Glu Ile Asp Gln Ile Asp Asp Gln 
1               5                   10                  15      

Ile Val Lys Leu Leu Glu Glu Arg Met His Leu Val Glu Gly Val Val 
            20                  25                  30          

Ala Tyr Lys Lys Ala Ser Gly Lys Pro Ile Leu Asp Thr Lys Arg Glu 
        35                  40                  45              

Glu Val Ile Phe Glu Lys Val Arg Ser Arg Val Glu Asp Lys Arg Tyr 
    50                  55                  60                  

Gln Glu Thr Ile Val Ala Thr Phe Ser Asp Ile Leu Lys Arg Ser Arg 
65                  70                  75                  80  

Asp Tyr Gln Asp Gln Asn Ile Lys 
                85              

<210>   2613
<211>   441
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2613
atggcattag caaaaattgt atttgccagt atgaccggta ataccgaaga aattgcagat   60
attgtagcag acaaattacg tgacttgggc ttggatgttg atgttgatga atgtacaact   120
gttgacgctt cagacttctt ggaagcagac atcgctatcg ttgcgaccta tacttatggt   180
gatggtgaat tgccagatga gatgatggac ttctacgaag acctagcaga tctcaacttg   240
aatggcaaaa tctacggagt ggtcggctca ggagatacct tctacgatga attctgtaag   300
gctgttgatg actttgaccg tgtctttgtg tcaacaggag cagaaaaagg ttcagagtgt   360
gttaaagttg atctttctgc cgaggaagaa gatattgaac gcttggaaca attcgcagaa   420
gaattggctg ctaaagtagg a                                             441

<210>   2614
<211>   147
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   flavodoxin (fld)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903218 (5.E-81)

<400>   2614
Met Ala Leu Ala Lys Ile Val Phe Ala Ser Met Thr Gly Asn Thr Glu 
1               5                   10                  15      

Glu Ile Ala Asp Ile Val Ala Asp Lys Leu Arg Asp Leu Gly Leu Asp 
            20                  25                  30          

Val Asp Val Asp Glu Cys Thr Thr Val Asp Ala Ser Asp Phe Leu Glu 
        35                  40                  45              

Ala Asp Ile Ala Ile Val Ala Thr Tyr Thr Tyr Gly Asp Gly Glu Leu 
    50                  55                  60                  

Pro Asp Glu Met Met Asp Phe Tyr Glu Asp Leu Ala Asp Leu Asn Leu 
65                  70                  75                  80  

Asn Gly Lys Ile Tyr Gly Val Val Gly Ser Gly Asp Thr Phe Tyr Asp 
                85                  90                  95      

Glu Phe Cys Lys Ala Val Asp Asp Phe Asp Arg Val Phe Val Ser Thr 
            100                 105                 110         

Gly Ala Glu Lys Gly Ser Glu Cys Val Lys Val Asp Leu Ser Ala Glu 
        115                 120                 125             

Glu Glu Asp Ile Glu Arg Leu Glu Gln Phe Ala Glu Glu Leu Ala Ala 
    130                 135                 140                 

Lys Val Gly 
145         

<210>   2615
<211>   933
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2615
atggagattt gccaacaaat tttagaaaaa attaaagaat acgacaccat tatcattcat   60
cgtcatatga aaccagaccc tgatgccttg ggaagtcagg tgggattgaa agccttgctg   120
gaacatcatt tcccagaaaa aaccatcaaa gccgtcggtt ttgatgaacc aactcttact   180
tggatggctg agatggatct tgttgaagat agagcctacc aaggcgcact tgtcatcgtc   240
tgtgatacag ctaatactgc tcgtatcgat gataagcgct atagtcaagg tgattttctc   300
attaagattg accaccatcc aaatgatgat gtatacggtg acctgtcttg ggtcgatact   360
agttcaagta gcgctagcga gatgattacc ctatttgccc aaacaaccca actagccttg   420
gcagatcgcg atgctgagtt gctctttgca ggaattgtcg gtgatacagg tcgcttcctc   480
tacccttcta ccactgcacg gactcttcgc ctggctgctt atttgagaga acataacttt   540
gactttgcgg ctctcactcg caaaatggac actatgagct acaaaattgc taaactgcaa   600
ggctacatct acgaccatct ggaagtggat gaaaatggtg ctgctcgcgt tatcctgagt   660
cagaaaatct tgaaacaata caatataacc gatgctgaaa ctgcggccat tgtaggtgca   720
cctggacgca ttgacagagt gagtctctgg ggaatttttg tcgaacaggc tgatggccac   780
taccgagttc gcttacgcag taaagtccat cctatcaatg aaattgccaa ggagcatgat   840
ggtggaggcc accctctagc aagtggtgct aattcctata gcctagaaga aaacgaaatc   900
atctaccaaa agttaaaaaa cttgcttaaa aac                                933

<210>   2616
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DHH subfamily 1 protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903219 (e-179)

<400>   2616
Met Glu Ile Cys Gln Gln Ile Leu Glu Lys Ile Lys Glu Tyr Asp Thr 
1               5                   10                  15      

Ile Ile Ile His Arg His Met Lys Pro Asp Pro Asp Ala Leu Gly Ser 
            20                  25                  30          

Gln Val Gly Leu Lys Ala Leu Leu Glu His His Phe Pro Glu Lys Thr 
        35                  40                  45              

Ile Lys Ala Val Gly Phe Asp Glu Pro Thr Leu Thr Trp Met Ala Glu 
    50                  55                  60                  

Met Asp Leu Val Glu Asp Arg Ala Tyr Gln Gly Ala Leu Val Ile Val 
65                  70                  75                  80  

Cys Asp Thr Ala Asn Thr Ala Arg Ile Asp Asp Lys Arg Tyr Ser Gln 
                85                  90                  95      

Gly Asp Phe Leu Ile Lys Ile Asp His His Pro Asn Asp Asp Val Tyr 

            100                 105                 110         

Gly Asp Leu Ser Trp Val Asp Thr Ser Ser Ser Ser Ala Ser Glu Met 
        115                 120                 125             

Ile Thr Leu Phe Ala Gln Thr Thr Gln Leu Ala Leu Ala Asp Arg Asp 
    130                 135                 140                 

Ala Glu Leu Leu Phe Ala Gly Ile Val Gly Asp Thr Gly Arg Phe Leu 
145                 150                 155                 160 

Tyr Pro Ser Thr Thr Ala Arg Thr Leu Arg Leu Ala Ala Tyr Leu Arg 
                165                 170                 175     

Glu His Asn Phe Asp Phe Ala Ala Leu Thr Arg Lys Met Asp Thr Met 
            180                 185                 190         

Ser Tyr Lys Ile Ala Lys Leu Gln Gly Tyr Ile Tyr Asp His Leu Glu 
        195                 200                 205             

Val Asp Glu Asn Gly Ala Ala Arg Val Ile Leu Ser Gln Lys Ile Leu 
    210                 215                 220                 

Lys Gln Tyr Asn Ile Thr Asp Ala Glu Thr Ala Ala Ile Val Gly Ala 
225                 230                 235                 240 

Pro Gly Arg Ile Asp Arg Val Ser Leu Trp Gly Ile Phe Val Glu Gln 
                245                 250                 255     

Ala Asp Gly His Tyr Arg Val Arg Leu Arg Ser Lys Val His Pro Ile 
            260                 265                 270         

Asn Glu Ile Ala Lys Glu His Asp Gly Gly Gly His Pro Leu Ala Ser 
        275                 280                 285             

Gly Ala Asn Ser Tyr Ser Leu Glu Glu Asn Glu Ile Ile Tyr Gln Lys 
    290                 295                 300                 

Leu Lys Asn Leu Leu Lys Asn 
305                 310     

<210>   2617
<211>   282
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2617
atggctcgca aagagaccat ggcagaaagg aaatattgca aaatgaaaaa agatatccat   60
ccagaatatc gcccagttgt cttcatggac acaactactg gttaccaatt ccttagcggt   120
tcaacaaaac gctctaacga aacagttgag ttcgaaggcg aaacttaccc attgatccgt   180
gtggaaattt catcagactc acacccattc tacactggac gtcaaaagtt cactcaagca   240
gatggacgcg tggatcgttt caacaaaaaa tacggtctca aa                      282

<210>   2618
<211>   94
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L31 (rpmE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903220 (5.E-44)

<400>   2618
Met Ala Arg Lys Glu Thr Met Ala Glu Arg Lys Tyr Cys Lys Met Lys 
1               5                   10                  15      

Lys Asp Ile His Pro Glu Tyr Arg Pro Val Val Phe Met Asp Thr Thr 
            20                  25                  30          

Thr Gly Tyr Gln Phe Leu Ser Gly Ser Thr Lys Arg Ser Asn Glu Thr 
        35                  40                  45              

Val Glu Phe Glu Gly Glu Thr Tyr Pro Leu Ile Arg Val Glu Ile Ser 
    50                  55                  60                  

Ser Asp Ser His Pro Phe Tyr Thr Gly Arg Gln Lys Phe Thr Gln Ala 
65                  70                  75                  80  

Asp Gly Arg Val Asp Arg Phe Asn Lys Lys Tyr Gly Leu Lys 
                85                  90                  

<210>   2619
<211>   216
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2619
atgagtataa gtcctcgttt tgaaacctta gagcaggcca ttgcctccaa agatttggaa   60
aaagtccgag aagcttttaa gaaaatgaat tccacttgga ccatcaatga aagtgtggtt   120
cgtgacaata gtatagctca ttatggacgt gttgaaacag ctatttcctt cctgcctagt   180
agcatggaaa tcgaacctac agatgagtct ggaaca                             216

<210>   2620
<211>   72
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903221 (3.E-34)

<400>   2620
Met Ser Ile Ser Pro Arg Phe Glu Thr Leu Glu Gln Ala Ile Ala Ser 
1               5                   10                  15      

Lys Asp Leu Glu Lys Val Arg Glu Ala Phe Lys Lys Met Asn Ser Thr 
            20                  25                  30          

Trp Thr Ile Asn Glu Ser Val Val Arg Asp Asn Ser Ile Ala His Tyr 
        35                  40                  45              

Gly Arg Val Glu Thr Ala Ile Ser Phe Leu Pro Ser Ser Met Glu Ile 
    50                  55                  60                  

Glu Pro Thr Asp Glu Ser Gly Thr 
65                  70          

<210>   2621
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2621
gtgtggaaag agattcgtaa acgtggattt aagaataaag cctttcgaac tttggaagat   60
gtcatgaatc aacttcaaga tgtcatacaa ggactggaga aggaggtgat aaagtccatc   120
ggtaatcgga gatggactag aatgcttttt gaaagcaga                          159

<210>   2622
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase family protein, truncation FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902761 (3.E-42)

<400>   2622
Met Trp Lys Glu Ile Arg Lys Arg Gly Phe Lys Asn Lys Ala Phe Arg 
1               5                   10                  15      

Thr Leu Glu Asp Val Met Asn Gln Leu Gln Asp Val Ile Gln Gly Leu 
            20                  25                  30          

Glu Lys Glu Val Ile Lys Ser Ile Gly Asn Arg Arg Trp Thr Arg Met 
        35                  40                  45              

Leu Phe Glu Ser Arg 
    50              

<210>   2623
<211>   249
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2623
atgggcaaat cttataaaga gattatagag cttttagact gtaatcaaac aacgatttgg   60
cgaaacgtaa aaaaatatga ggagttcgga ctcgactctc tccttcaaga aacacgtggt   120
ggtcgtaacc atgcatatat gacagttgag gaagagaaag cctttcttgc ccgtcatttg   180
aaggctacag aggcaggaga atttgttaca attgatgcct tatttcaggt ttataaaaag   240
gagtgtgga                                                           249

<210>   2624
<211>   83
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (Degenerate transposase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902688 (1.E-47)

<400>   2624
Met Gly Lys Ser Tyr Lys Glu Ile Ile Glu Leu Leu Asp Cys Asn Gln 
1               5                   10                  15      

Thr Thr Ile Trp Arg Asn Val Lys Lys Tyr Glu Glu Phe Gly Leu Asp 
            20                  25                  30          

Ser Leu Leu Gln Glu Thr Arg Gly Gly Arg Asn His Ala Tyr Met Thr 
        35                  40                  45              


Val Glu Glu Glu Lys Ala Phe Leu Ala Arg His Leu Lys Ala Thr Glu 
    50                  55                  60                  

Ala Gly Glu Phe Val Thr Ile Asp Ala Leu Phe Gln Val Tyr Lys Lys 
65                  70                  75                  80  

Glu Cys Gly 
            

<210>   2625
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2625
atgaaatcaa ctaaagaaga aatccaaacc atcaaaacac ttttaaaaga ctctcgtaca   60
gctaaatatt ataaacgcct tcaaatcgtt cta                                93

<210>   2626
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2626
Met Lys Ser Thr Lys Glu Glu Ile Gln Thr Ile Lys Thr Leu Leu Lys 
1               5                   10                  15      

Asp Ser Arg Thr Ala Lys Tyr Tyr Lys Arg Leu Gln Ile Val Leu 
            20                  25                  30      

<210>   2627
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2627
ttggtttttt tgaaaataga taaaaaaacg aacgtttttc ttggaaatat ctttctcaaa   60
gacaaaatct taaagtatgc tataagaaaa gaaaatgtt                          99

<210>   2628
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2628
Met Val Phe Leu Lys Ile Asp Lys Lys Thr Asn Val Phe Leu Gly Asn 
1               5                   10                  15      

Ile Phe Leu Lys Asp Lys Ile Leu Lys Tyr Ala Ile Arg Lys Glu Asn 
            20                  25                  30          

Val 
    

<210>   2629
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2629
ttgaaagaat ttttagaaaa tttctgtttt ttctttacag tgaaaaaaaa ttctgctata   60
atgtcttatg taataaaata tgacaataaa aggagaacga ta                      102

<210>   2630
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2630
Met Lys Glu Phe Leu Glu Asn Phe Cys Phe Phe Phe Thr Val Lys Lys 
1               5                   10                  15      

Asn Ser Ala Ile Met Ser Tyr Val Ile Lys Tyr Asp Asn Lys Arg Arg 
            20                  25                  30          

Thr Ile 
        

<210>   2631
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2631
atgacatctg ctaaagaata tatccaaagc gtgtttgaaa ctgtgaaagc tcgtaacggg   60
cacgaggctg aattcctcca agctgttgaa gaatttttca acactttaga acctgtattt   120
gaaaaacacc ctgagtatat cgaagaaaat atcttggcac gtattactga gcctgagcgc   180
gtggtttctt tccgtgttcc ttgggttgac cgtgatggaa aaattcaagt aaaccgtggt   240
taccgtgttc aattcaactc agctgttgga ccatacaaag gtggacttcg tttccaccca   300
actgtaaacc aagggatctt gaaattcctc ggatttgaac aaatctttaa aaatgtcttg   360
actggacttc ctatcggtgg aggtaaaggt ggatcagact tcgatcctaa aggtaaaaca   420
gatgctgaag tgatgcgctt ctgccaaagc ttcatgactg aattgcaaaa acacatcgga   480
ccatcacttg acgtacctgc tggtgatatc ggtgttggtg gacgtgaaat tggttacctt   540
tacggtcaat acaaacgtct taaccaattt gatgctggtg tcttgactgg taaacctctt   600
ggatttggtg gtagcttgat tcgtccagaa gcaactggtt acggtttggt ttactatact   660
gaagaaatgc tcaaagctaa cggtaacagc tttgctggta agaaagtcgt tatttcaggt   720
tctggtaacg ttgctcaata tgctcttcaa aaagcaactg aactcggtgc aactgttatt   780
tctgtttctg actcaaatgg ttatgtcatc gatgaaaatg gtatcgactt cgatcttttg   840
gttgatgtta aagaaaaacg tcgtgctcgt ttgactgagt atgcagctga aaaagcaact   900
gcaacctacc acgaaggtac tgtatggact tacgctggaa actatgacat tgctcttcca   960
tgtgccactc aaaacgaaat caacggtgaa gcagctaaac gtttggttgc tcaaggcgtt   1020
atctgtgtat ctgaaggtgc caacatgccg agcgaccttg atgccatcaa agtttacaaa   1080
gaaaatggta tcttctacgg acctgcaaaa gctgccaacg ctggtggtgt agccgtttca   1140
gctcttgaaa tgagccaaaa cagtcttcgc ctctcatgga ctcgtgaaga agttgatggc   1200
cgtctcaaag acatcatgac aaacatcttc aacacagcta aaacgacttc agaaacatac   1260
ggtcttgata aagactacct tgcaggagct aacattgctg cctttgaaaa tgtagcaaat   1320
gccatgattg cacaaggtat tgtt                                          1344

<210>   2632
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   NADP-specific glutamate dehydrogenase (gdhA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903224 (0.E+01)

<400>   2632
Met Thr Ser Ala Lys Glu Tyr Ile Gln Ser Val Phe Glu Thr Val Lys 
1               5                   10                  15      

Ala Arg Asn Gly His Glu Ala Glu Phe Leu Gln Ala Val Glu Glu Phe 
            20                  25                  30          

Phe Asn Thr Leu Glu Pro Val Phe Glu Lys His Pro Glu Tyr Ile Glu 
        35                  40                  45              

Glu Asn Ile Leu Ala Arg Ile Thr Glu Pro Glu Arg Val Val Ser Phe 
    50                  55                  60                  

Arg Val Pro Trp Val Asp Arg Asp Gly Lys Ile Gln Val Asn Arg Gly 
65                  70                  75                  80  

Tyr Arg Val Gln Phe Asn Ser Ala Val Gly Pro Tyr Lys Gly Gly Leu 
                85                  90                  95      

Arg Phe His Pro Thr Val Asn Gln Gly Ile Leu Lys Phe Leu Gly Phe 
            100                 105                 110         

Glu Gln Ile Phe Lys Asn Val Leu Thr Gly Leu Pro Ile Gly Gly Gly 
        115                 120                 125             

Lys Gly Gly Ser Asp Phe Asp Pro Lys Gly Lys Thr Asp Ala Glu Val 
    130                 135                 140                 

Met Arg Phe Cys Gln Ser Phe Met Thr Glu Leu Gln Lys His Ile Gly 
145                 150                 155                 160 

Pro Ser Leu Asp Val Pro Ala Gly Asp Ile Gly Val Gly Gly Arg Glu 
                165                 170                 175     

Ile Gly Tyr Leu Tyr Gly Gln Tyr Lys Arg Leu Asn Gln Phe Asp Ala 
            180                 185                 190         

Gly Val Leu Thr Gly Lys Pro Leu Gly Phe Gly Gly Ser Leu Ile Arg 
        195                 200                 205             

Pro Glu Ala Thr Gly Tyr Gly Leu Val Tyr Tyr Thr Glu Glu Met Leu 
    210                 215                 220                 

Lys Ala Asn Gly Asn Ser Phe Ala Gly Lys Lys Val Val Ile Ser Gly 
225                 230                 235                 240 

Ser Gly Asn Val Ala Gln Tyr Ala Leu Gln Lys Ala Thr Glu Leu Gly 
                245                 250                 255     

Ala Thr Val Ile Ser Val Ser Asp Ser Asn Gly Tyr Val Ile Asp Glu 
            260                 265                 270         

Asn Gly Ile Asp Phe Asp Leu Leu Val Asp Val Lys Glu Lys Arg Arg 
        275                 280                 285             

Ala Arg Leu Thr Glu Tyr Ala Ala Glu Lys Ala Thr Ala Thr Tyr His 
    290                 295                 300                 

Glu Gly Thr Val Trp Thr Tyr Ala Gly Asn Tyr Asp Ile Ala Leu Pro 
305                 310                 315                 320 

Cys Ala Thr Gln Asn Glu Ile Asn Gly Glu Ala Ala Lys Arg Leu Val 
                325                 330                 335     

Ala Gln Gly Val Ile Cys Val Ser Glu Gly Ala Asn Met Pro Ser Asp 
            340                 345                 350         

Leu Asp Ala Ile Lys Val Tyr Lys Glu Asn Gly Ile Phe Tyr Gly Pro 

        355                 360                 365             

Ala Lys Ala Ala Asn Ala Gly Gly Val Ala Val Ser Ala Leu Glu Met 
    370                 375                 380                 

Ser Gln Asn Ser Leu Arg Leu Ser Trp Thr Arg Glu Glu Val Asp Gly 
385                 390                 395                 400 

Arg Leu Lys Asp Ile Met Thr Asn Ile Phe Asn Thr Ala Lys Thr Thr 
                405                 410                 415     

Ser Glu Thr Tyr Gly Leu Asp Lys Asp Tyr Leu Ala Gly Ala Asn Ile 
            420                 425                 430         

Ala Ala Phe Glu Asn Val Ala Asn Ala Met Ile Ala Gln Gly Ile Val 
        435                 440                 445             


<210>   2633
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2633
ttgctttacc gtactcaagt acagcctgcg gctcgcttcc tagtttgctc tttgattttc   60
attgagtata aaaagggtca agtaagtata gtaaat                             96

<210>   2634
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein

<400>   2634
Met Leu Tyr Arg Thr Gln Val Gln Pro Ala Ala Arg Phe Leu Val Cys 
1               5                   10                  15      

Ser Leu Ile Phe Ile Glu Tyr Lys Lys Gly Gln Val Ser Ile Val Asn 
            20                  25                  30          


<210>   2635
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2635
atgaagaaag aaaatgaata tgtaatttta acaacagcct cactaggggt gatgattgga   60
atagtgtttg caattttttt agattttcca gttgaatatg gtatttcttt aggcttgttg   120
aatggaatag tattgggttc gctgattgtt tacaaaaaca ataagaat                168

<210>   2636
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903225 (4.E-27)

<400>   2636
Met Lys Lys Glu Asn Glu Tyr Val Ile Leu Thr Thr Ala Ser Leu Gly 
1               5                   10                  15      

Val Met Ile Gly Ile Val Phe Ala Ile Phe Leu Asp Phe Pro Val Glu 
            20                  25                  30          

Tyr Gly Ile Ser Leu Gly Leu Leu Asn Gly Ile Val Leu Gly Ser Leu 
        35                  40                  45              

Ile Val Tyr Lys Asn Asn Lys Asn 
    50                  55      

<210>   2637
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2637
atggctatgc cgatgaaatt taatactatc atctcagaga tggggtcaaa tatttcaggt   60
gggcaaaggc aacggatagc actggcacgt gcattaataa ataatcctag tattgtaatt   120
ttagatgaag caactagtgc attagacact attaatgagg aaagaataac aaagtatata   180
caaagtcagg gctgtactca aataattgta gctcatagat tgtcaacgat taaggatgcg   240
gatgttattt ttgtaatgaa aggtggtaag attgttgagt caggaaatca taagtactta   300
atggatcttg gtggagagta ctacagctta tatacaaaaa ggaaa                   345

<210>   2638
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   toxin secretion ATP-binding protein, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903226 (e-103)

<400>   2638
Met Ala Met Pro Met Lys Phe Asn Thr Ile Ile Ser Glu Met Gly Ser 
1               5                   10                  15      

Asn Ile Ser Gly Gly Gln Arg Gln Arg Ile Ala Leu Ala Arg Ala Leu 
            20                  25                  30          

Ile Asn Asn Pro Ser Ile Val Ile Leu Asp Glu Ala Thr Ser Ala Leu 
        35                  40                  45              

Asp Thr Ile Asn Glu Glu Arg Ile Thr Lys Tyr Ile Gln Ser Gln Gly 
    50                  55                  60                  

Cys Thr Gln Ile Ile Val Ala His Arg Leu Ser Thr Ile Lys Asp Ala 
65                  70                  75                  80  

Asp Val Ile Phe Val Met Lys Gly Gly Lys Ile Val Glu Ser Gly Asn 
                85                  90                  95      

His Lys Tyr Leu Met Asp Leu Gly Gly Glu Tyr Tyr Ser Leu Tyr Thr 
            100                 105                 110         

Lys Arg Lys 
        115 

<210>   2639
<211>   386
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2639
atgaaggctc aagcgattgt cacaagtcaa gggagaattg tttctttgga tatcactgtg   60
aactattgtc atgatatgaa gttgttcaaa atgagtcgca gaaatatcag acaagctggt   120
aaaatcttgg ctgacagtgg ttatcaaggg ctcatgaaga tatatcctca agcacaaact   180
tcacgtaaat ccagcaaact caaaccgcta acaattgaag ataaagtcta taaccatgcg   240
ctatctaagg agagaagcaa ggttgagaac atctttgcca aagtaaaaac gtttaaaatg   300
atttcaacaa cctatcgaaa tcatctaaac gcttcggatt acgaatgaat ttgattgctg   360
gtattatcaa tcatgaacta ggattc                                        386

<210>   2640
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfB FRAMESHIFT

<400>   2640
Met Lys Ala Gln Ala Ile Val Thr Ser Gln Gly Arg Ile Val Ser Leu 
1               5                   10                  15      

Asp Ile Thr Val Asn Tyr Cys His Asp Met Lys Leu Phe Lys Met Ser 
            20                  25                  30          

Arg Arg Asn Ile Arg Gln Ala Gly Lys Ile Leu Ala Asp Ser Gly Tyr 
        35                  40                  45              

Gln Gly Leu Met Lys Ile Tyr Pro Gln Ala Gln Thr Ser Arg Lys Ser 
    50                  55                  60                  

Ser Lys Leu Lys Pro Leu Thr Ile Glu Asp Lys Val Tyr Asn His Ala 
65                  70                  75                  80  

Leu Ser Lys Glu Arg Ser Lys Val Glu Asn Ile Phe Ala Lys Val Lys 
                85                  90                  95      

Thr Phe Lys Met Ile Ser Thr Thr Tyr Arg Asn His Leu Asn Ala Ser 
            100                 105                 110         

Asp Tyr Glu 
        115 

<210>   2641
<211>   396
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2641
atgaatgatg aagcaagtaa acaactaacc gatgcacgat ttaagcgtct tgttggtgtt   60
caacgcacga cttttgaaga gatgttagct gtattaaaaa cagcttatca acttaaacac   120
gcaaaaggtg gacgaaaacc taaattaagt ctagaagacc ttcttatggc cactcttcaa   180
tatgtgcgag aatatcgaac ttatgaacaa attgcggctg tttttggtat tcacgaaagc   240
aacttaatcc gtcggagcca atgggttgaa gtaactcttg ttcaaagtgg tgttacgatt   300
tcaagaactc ctctcagttc tgaggacacg gtaatgattg atgcgacgga agtaaaaatc   360
aatcgcccta aaaaaagaat tagcgaatta ttctgg                             396

<210>   2642
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903037 (7.E-68)

<400>   2642
Met Asn Asp Glu Ala Ser Lys Gln Leu Thr Asp Ala Arg Phe Lys Arg 
1               5                   10                  15      

Leu Val Gly Val Gln Arg Thr Thr Phe Glu Glu Met Leu Ala Val Leu 
            20                  25                  30          

Lys Thr Ala Tyr Gln Leu Lys His Ala Lys Gly Gly Arg Lys Pro Lys 
        35                  40                  45              

Leu Ser Leu Glu Asp Leu Leu Met Ala Thr Leu Gln Tyr Val Arg Glu 
    50                  55                  60                  

Tyr Arg Thr Tyr Glu Gln Ile Ala Ala Val Phe Gly Ile His Glu Ser 
65                  70                  75                  80  

Asn Leu Ile Arg Arg Ser Gln Trp Val Glu Val Thr Leu Val Gln Ser 
                85                  90                  95      

Gly Val Thr Ile Ser Arg Thr Pro Leu Ser Ser Glu Asp Thr Val Met 
            100                 105                 110         

Ile Asp Ala Thr Glu Val Lys Ile Asn Arg Pro Lys Lys Arg Ile Ser 
        115                 120                 125             

Glu Leu Phe Trp 
    130         

<210>   2643
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2643
atggtaaata agcctctaaa acctctttgt ttacgagagt ttcctcgttt ggaagacatt   60
ctagaagata ggatagatat ttctcgctat ttaattgatg acgtt                   105

<210>   2644
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2644
Met Val Asn Lys Pro Leu Lys Pro Leu Cys Leu Arg Glu Phe Pro Arg 
1               5                   10                  15      

Leu Glu Asp Ile Leu Glu Asp Arg Ile Asp Ile Ser Arg Tyr Leu Ile 
            20                  25                  30          

Asp Asp Val 
        35  

<210>   2645
<211>   156
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2645
atgagtttgt tggaaacagc taaacgtcat caattaaata gcgagaaata tctatcctat   60
cttctagaat gtcttccaaa cgaggaaact ctcgtaaaca aagaggtttt agaggcttat   120
ttaccatgga ctaaagttgt acaagaaaag tgcaaa                             156

<210>   2646
<211>   52
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2646
Met Ser Leu Leu Glu Thr Ala Lys Arg His Gln Leu Asn Ser Glu Lys 
1               5                   10                  15      

Tyr Leu Ser Tyr Leu Leu Glu Cys Leu Pro Asn Glu Glu Thr Leu Val 
            20                  25                  30          

Asn Lys Glu Val Leu Glu Ala Tyr Leu Pro Trp Thr Lys Val Val Gln 
        35                  40                  45              

Glu Lys Cys Lys 
    50          

<210>   2647
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2647
ttgaaagacg gacatctggt cctttccaat aatctagctg aacgcgccat taaatcattg   60
gttatgggac ggagtaaaag agtccagtgg actcttttag cc                      102

<210>   2648
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2648
Met Lys Asp Gly His Leu Val Leu Ser Asn Asn Leu Ala Glu Arg Ala 
1               5                   10                  15      

Ile Lys Ser Leu Val Met Gly Arg Ser Lys Arg Val Gln Trp Thr Leu 
            20                  25                  30          

Leu Ala 
        

<210>   2649
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2649
ttgaagcgcc cccccaagca agcggataaa tcatccttag gagctaaagg tttagcttat   60
tgtgatcagt tattttcctt ggaaagagac tgggaggctt tgccagctga tgaacgacta   120
cagaaacgtc aagaacatct ccagccctta atggaagact tctttgct                168

<210>   2650
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2650
Met Lys Arg Pro Pro Lys Gln Ala Asp Lys Ser Ser Leu Gly Ala Lys 
1               5                   10                  15      

Gly Leu Ala Tyr Cys Asp Gln Leu Phe Ser Leu Glu Arg Asp Trp Glu 
            20                  25                  30          

Ala Leu Pro Ala Asp Glu Arg Leu Gln Lys Arg Gln Glu His Leu Gln 
        35                  40                  45              

Pro Leu Met Glu Asp Phe Phe Ala 
    50                  55      

<210>   2651
<211>   438
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2651
gtgaaatctc ctattcctaa agccccttta gcgcataact ttggctcagc ttctattatc   60
gctcacacca tccatcagaa gtttaatctg aaggtaccca attatcgcca agaagaagat   120
tgggctagga tgggtttacc aatcacacgt aaggaaatct ctaattggca tatcaaggcg   180
agtcaatact atttggagcc cctttataac ctcttgcgag agagactatt gactcagccc   240
ttacttcatg cggatgaaac ttcttatagg gtgctagaga gtgatagtca gctgacttac   300
tattggactt ttttgtcagg taaagcagag aaacaaggga ttacgcttta ccaccatgat   360
cagtgtcgaa gtggttcagt agtacaagaa ttcctaggag attattctgg ctatgtgcat   420
tgtgatattt tgcggcag                                                 438

<210>   2652
<211>   146
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf3, degenerate

<400>   2652
Met Lys Ser Pro Ile Pro Lys Ala Pro Leu Ala His Asn Phe Gly Ser 
1               5                   10                  15      

Ala Ser Ile Ile Ala His Thr Ile His Gln Lys Phe Asn Leu Lys Val 
            20                  25                  30          

Pro Asn Tyr Arg Gln Glu Glu Asp Trp Ala Arg Met Gly Leu Pro Ile 
        35                  40                  45              

Thr Arg Lys Glu Ile Ser Asn Trp His Ile Lys Ala Ser Gln Tyr Tyr 
    50                  55                  60                  

Leu Glu Pro Leu Tyr Asn Leu Leu Arg Glu Arg Leu Leu Thr Gln Pro 
65                  70                  75                  80  

Leu Leu His Ala Asp Glu Thr Ser Tyr Arg Val Leu Glu Ser Asp Ser 
                85                  90                  95      

Gln Leu Thr Tyr Tyr Trp Thr Phe Leu Ser Gly Lys Ala Glu Lys Gln 
            100                 105                 110         

Gly Ile Thr Leu Tyr His His Asp Gln Cys Arg Ser Gly Ser Val Val 
        115                 120                 125             

Gln Glu Phe Leu Gly Asp Tyr Ser Gly Tyr Val His Cys Asp Ile Leu 
    130                 135                 140                 

Arg Gln 
145     

<210>   2653
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2653
atggacaatg ctatatggca taaatcaagt accttaaaga ttccgactaa tattggcttt   60
gcatttattc ctccatacac accagagatg aaccccattg aacaagtgtg gaaagagatt   120
cgtaaacgtg gatttaagaa taaagccttt                                    150

<210>   2654
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   transposase family protein, truncation POINT MUTATION
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903342 (6.E-38)

<400>   2654
Met Asp Asn Ala Ile Trp His Lys Ser Ser Thr Leu Lys Ile Pro Thr 
1               5                   10                  15      

Asn Ile Gly Phe Ala Phe Ile Pro Pro Tyr Thr Pro Glu Met Asn Pro 
            20                  25                  30          

Ile Glu Gln Val Trp Lys Glu Ile Arg Lys Arg Gly Phe Lys Asn Lys 
        35                  40                  45              

Ala Phe 
    50  

<210>   2655
<211>   321
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2655
atgacaattc atctatctag cctaggggag gtctatctcg tgtgtgggaa aactgatatg   60
agacaaggaa tcgattcact ggcttatctg gttaaaaccc actttgaatt ggatcctttc   120
tccggtcaag tctttctctt ttgtggtgga cgtaaagacc gctttaaagt cctttactgg   180
gatggtcaag gattttggct actatataaa cgctttgaga acggcagatt gatttggcta   240
agtacagaaa aggatgtcaa agctctcaca ccagaacaag tagactggct tatgaagggc   300
ttttctatca ctccaaaaat a                                             321

<210>   2656
<211>   107
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf2, interruption
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904060 (0.E+01)

<400>   2656
Met Thr Ile His Leu Ser Ser Leu Gly Glu Val Tyr Leu Val Cys Gly 
1               5                   10                  15      

Lys Thr Asp Met Arg Gln Gly Ile Asp Ser Leu Ala Tyr Leu Val Lys 
            20                  25                  30          

Thr His Phe Glu Leu Asp Pro Phe Ser Gly Gln Val Phe Leu Phe Cys 
        35                  40                  45              

Gly Gly Arg Lys Asp Arg Phe Lys Val Leu Tyr Trp Asp Gly Gln Gly 
    50                  55                  60                  

Phe Trp Leu Leu Tyr Lys Arg Phe Glu Asn Gly Arg Leu Ile Trp Leu 
65                  70                  75                  80  

Ser Thr Glu Lys Asp Val Lys Ala Leu Thr Pro Glu Gln Val Asp Trp 
                85                  90                  95      

Leu Met Lys Gly Phe Ser Ile Thr Pro Lys Ile 
            100                 105         

<210>   2657
<211>   414
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2657
ttggataagg ctttaagcct ttctaagctt tttttattga cagtatcagg atatcttttt   60
caaaattttg gtttgttaga taatgaaaat gtttctacta atctagattt aggattagta   120
aatcgtaaat gtaattatat agaaagtaag cgcgtcataa caaggtatct atcattcatg   180
gagctcctcc tgtatactat tagtaaagta aaactattgg aggatatttt aatgccacaa   240
cctattgttc ctgtagagat tccacaatct cgtcgttttg attctaaaaa gagaaatgat   300
attctgctta aaattcgtat tggcaagctt gaagtaagtt tttttcaatc tctcaatctc   360
gaaatggtag aacagctttt ggataaggtg ttgctctatg acaattcatc tatc         414

<210>   2658
<211>   138
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf1
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903342 (1.E-38)

<400>   2658
Met Asp Lys Ala Leu Ser Leu Ser Lys Leu Phe Leu Leu Thr Val Ser 
1               5                   10                  15      

Gly Tyr Leu Phe Gln Asn Phe Gly Leu Leu Asp Asn Glu Asn Val Ser 
            20                  25                  30          

Thr Asn Leu Asp Leu Gly Leu Val Asn Arg Lys Cys Asn Tyr Ile Glu 
        35                  40                  45              

Ser Lys Arg Val Ile Thr Arg Tyr Leu Ser Phe Met Glu Leu Leu Leu 
    50                  55                  60                  

Tyr Thr Ile Ser Lys Val Lys Leu Leu Glu Asp Ile Leu Met Pro Gln 
65                  70                  75                  80  

Pro Ile Val Pro Val Glu Ile Pro Gln Ser Arg Arg Phe Asp Ser Lys 
                85                  90                  95      

Lys Arg Asn Asp Ile Leu Leu Lys Ile Arg Ile Gly Lys Leu Glu Val 
            100                 105                 110         

Ser Phe Phe Gln Ser Leu Asn Leu Glu Met Val Glu Gln Leu Leu Asp 
        115                 120                 125             

Lys Val Leu Leu Tyr Asp Asn Ser Ser Ile 
    130                 135             

<210>   2659
<211>   609
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2659
atggtacgtt tgaatgtaaa accaactcgt atggaattga ataacttaaa ggaacgtttg   60
acaacagctg aacgtggaca taagttatta aaggataaaa gagatgaatt gatgaggcga   120
tttatttctt tgattcgtga gaataatcaa cttcggaaag aagtggaaag ttatctaatt   180
gataatctaa aatcctttgc agttgctaaa tcattaaaga attctcaaat ggtggaggaa   240
ttattttcaa ttccatcgaa agaaattgaa ttatttgttg agaaagaaaa tatcatgagt   300
gtaacagttc ctagaatgca tatgaatatt acttctcaaa atgagaacag tgaatacagc   360
tatttatctt ctaatagtga aatggatgat gtatttgcta caatgaatag tttaatttat   420
aaattactaa gactggcaga agttgaaaaa acgtgtcagt taatggctga tgaaatagaa   480
aaaacacgta gacgtgtaaa tggtttagaa tactcgatta ttccaaactt gtcggaaact   540
attcattata tagaattgaa actagaggag gcagaaagag ccaatttagt tcgtattatg   600
aaagtgaag                                                           609

<210>   2660
<211>   203
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   v-type sodium ATP synthase, subunit D (ntpD)
<223>   Cellular location: cytoplasm

<400>   2660
Met Val Arg Leu Asn Val Lys Pro Thr Arg Met Glu Leu Asn Asn Leu 
1               5                   10                  15      

Lys Glu Arg Leu Thr Thr Ala Glu Arg Gly His Lys Leu Leu Lys Asp 
            20                  25                  30          

Lys Arg Asp Glu Leu Met Arg Arg Phe Ile Ser Leu Ile Arg Glu Asn 
        35                  40                  45              

Asn Gln Leu Arg Lys Glu Val Glu Ser Tyr Leu Ile Asp Asn Leu Lys 
    50                  55                  60                  

Ser Phe Ala Val Ala Lys Ser Leu Lys Asn Ser Gln Met Val Glu Glu 
65                  70                  75                  80  

Leu Phe Ser Ile Pro Ser Lys Glu Ile Glu Leu Phe Val Glu Lys Glu 
                85                  90                  95      

Asn Ile Met Ser Val Thr Val Pro Arg Met His Met Asn Ile Thr Ser 
            100                 105                 110         

Gln Asn Glu Asn Ser Glu Tyr Ser Tyr Leu Ser Ser Asn Ser Glu Met 
        115                 120                 125             

Asp Asp Val Phe Ala Thr Met Asn Ser Leu Ile Tyr Lys Leu Leu Arg 
    130                 135                 140                 

Leu Ala Glu Val Glu Lys Thr Cys Gln Leu Met Ala Asp Glu Ile Glu 
145                 150                 155                 160 

Lys Thr Arg Arg Arg Val Asn Gly Leu Glu Tyr Ser Ile Ile Pro Asn 
                165                 170                 175     

Leu Ser Glu Thr Ile His Tyr Ile Glu Leu Lys Leu Glu Glu Ala Glu 
            180                 185                 190         

Arg Ala Asn Leu Val Arg Ile Met Lys Val Lys 
        195                 200             

<210>   2661
<211>   1383
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2661
atgagtgtta taaaagaata cagaactgct agtgaagttg ttgggcctct tatgattgtt   60
gaacaagtaa ataatgtgtc ttacaatgag ttagttgaaa ttcaacttca taatggagaa   120
attcgtcgtg gacaagtttt agagatccac gaagataaag caatggttca gctttttgaa   180
ggatctagtg gaataaattt agaaaagtct aaaattcgtt ttgctggtca tgcattagaa   240
ttggctgtat ctgaggatat ggttggtcgt atttttaatg ggatgggaaa accaattgat   300
ggtggaccag atttaattcc agagaaatat ttagatattg atggtcaagc tattaatcct   360
gtatctagag attatccaga tgaatttatt cagacaggga tctcctctat tgatcatttg   420
aatactcttg tacgtggtca aaaattacca gtattttcag gttcgggctt acctcataat   480
gaattagctg ctcagatagc aagacaagcg actgttttaa attctgatga aaattttgcg   540
gttgtatttg cagcaatggg tattactttt gaagaagctg agttttttat ggaagaactc   600
agaaaaacag gagcgatcga tcgttcggtt ttatttatga acttggcaaa tgatcctgca   660
attgagcgta ttgcaactcc ccgcattgct ttaactgcgg cagagtatct agcttttgaa   720
aaagatatgc acgttctagt tatcatgacg gatatgacta actattgtga agcgttacgt   780
gaagtctcgg cagctcgccg tgaagttcca gggagacgag gctatccggg atatttatat   840
acaaatttat caactctata cgaaagggct ggtcgcttag ttggtaaaaa aggttcggtg   900
acacagattc ctattttaac aatgccagaa gatgacataa cacatccaat tcctgattta   960
actggataca ttactgaagg gcaaattatt ttgtcgcatg agttgtataa tcaaggttat   1020
cgtccaccaa tcaatgtttt accttctctc tctcgattaa aagataaggg atctggagaa   1080
ggtaaaactc gtggagatca tgctccaact atgaatcaac tgtttgcagc ctatgcccaa   1140
gggaaaaagg ttgaagagtt agcagtagta ttaggagaat cggctttatc tgatgtagat   1200
aaattgtatg tgaggtttac aaagcgtttt gaagaagagt acataaacca aggattttat   1260
aaaaatcgaa atatagaaga tacgttgaat cttgggtggg aattactatc aattcttcct   1320
agaacagagt taaaacgtat caaagatgat ttgcttgata aatacttacc tttggtagaa   1380
gtt                                                                 1383

<210>   2662
<211>   461
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   v-type sodium ATP synthase, subunit B (ntpB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903405 (2.E-31)

<400>   2662
Met Ser Val Ile Lys Glu Tyr Arg Thr Ala Ser Glu Val Val Gly Pro 
1               5                   10                  15      

Leu Met Ile Val Glu Gln Val Asn Asn Val Ser Tyr Asn Glu Leu Val 
            20                  25                  30          

Glu Ile Gln Leu His Asn Gly Glu Ile Arg Arg Gly Gln Val Leu Glu 
        35                  40                  45              

Ile His Glu Asp Lys Ala Met Val Gln Leu Phe Glu Gly Ser Ser Gly 
    50                  55                  60                  

Ile Asn Leu Glu Lys Ser Lys Ile Arg Phe Ala Gly His Ala Leu Glu 
65                  70                  75                  80  

Leu Ala Val Ser Glu Asp Met Val Gly Arg Ile Phe Asn Gly Met Gly 
                85                  90                  95      

Lys Pro Ile Asp Gly Gly Pro Asp Leu Ile Pro Glu Lys Tyr Leu Asp 
            100                 105                 110         

Ile Asp Gly Gln Ala Ile Asn Pro Val Ser Arg Asp Tyr Pro Asp Glu 
        115                 120                 125             

Phe Ile Gln Thr Gly Ile Ser Ser Ile Asp His Leu Asn Thr Leu Val 
    130                 135                 140                 

Arg Gly Gln Lys Leu Pro Val Phe Ser Gly Ser Gly Leu Pro His Asn 
145                 150                 155                 160 

Glu Leu Ala Ala Gln Ile Ala Arg Gln Ala Thr Val Leu Asn Ser Asp 
                165                 170                 175     

Glu Asn Phe Ala Val Val Phe Ala Ala Met Gly Ile Thr Phe Glu Glu 
            180                 185                 190         

Ala Glu Phe Phe Met Glu Glu Leu Arg Lys Thr Gly Ala Ile Asp Arg 
        195                 200                 205             

Ser Val Leu Phe Met Asn Leu Ala Asn Asp Pro Ala Ile Glu Arg Ile 
    210                 215                 220                 

Ala Thr Pro Arg Ile Ala Leu Thr Ala Ala Glu Tyr Leu Ala Phe Glu 
225                 230                 235                 240 

Lys Asp Met His Val Leu Val Ile Met Thr Asp Met Thr Asn Tyr Cys 
                245                 250                 255     

Glu Ala Leu Arg Glu Val Ser Ala Ala Arg Arg Glu Val Pro Gly Arg 
            260                 265                 270         

Arg Gly Tyr Pro Gly Tyr Leu Tyr Thr Asn Leu Ser Thr Leu Tyr Glu 
        275                 280                 285             

Arg Ala Gly Arg Leu Val Gly Lys Lys Gly Ser Val Thr Gln Ile Pro 
    290                 295                 300                 

Ile Leu Thr Met Pro Glu Asp Asp Ile Thr His Pro Ile Pro Asp Leu 
305                 310                 315                 320 

Thr Gly Tyr Ile Thr Glu Gly Gln Ile Ile Leu Ser His Glu Leu Tyr 
                325                 330                 335     

Asn Gln Gly Tyr Arg Pro Pro Ile Asn Val Leu Pro Ser Leu Ser Arg 
            340                 345                 350         

Leu Lys Asp Lys Gly Ser Gly Glu Gly Lys Thr Arg Gly Asp His Ala 
        355                 360                 365             

Pro Thr Met Asn Gln Leu Phe Ala Ala Tyr Ala Gln Gly Lys Lys Val 
    370                 375                 380                 

Glu Glu Leu Ala Val Val Leu Gly Glu Ser Ala Leu Ser Asp Val Asp 
385                 390                 395                 400 

Lys Leu Tyr Val Arg Phe Thr Lys Arg Phe Glu Glu Glu Tyr Ile Asn 
                405                 410                 415     

Gln Gly Phe Tyr Lys Asn Arg Asn Ile Glu Asp Thr Leu Asn Leu Gly 
            420                 425                 430         

Trp Glu Leu Leu Ser Ile Leu Pro Arg Thr Glu Leu Lys Arg Ile Lys 
        435                 440                 445             

Asp Asp Leu Leu Asp Lys Tyr Leu Pro Leu Val Glu Val 
    450                 455                 460     

<210>   2663
<211>   1773
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2663
ttgactcaag ggaagattat aaaagtatcg ggacctctag ttattgcatc aggtatgcag   60
gaggctaata ttcaagatat ttgccgtgta ggtaagctag ggttaatcgg tgaaattatt   120
gaaatgagaa gagatcaggc atctatccaa gtctatgaag aaacatctgg tcttggtccg   180
ggagaacctg ttgttacaac tggagaacct ctctcggttg aattagggcc aggattgatt   240
tctcaaatgt ttgatggcat acaacgccca ttagatcgat ttaaattggc tactcataat   300
gattttctag ttcgtggggt agaagttcca agtttggata gagatattaa gtggcatttt   360
gattccacta tagcaattgg tcaaaaagtg agtacgggtg atattcttgg aactgtcaag   420
gaaaccgagg tagttaatca taaaattatg gttccttatg gagtatctgg agaagtcgtt   480
tctattgcat ctggcgattt tacaattgat gaagttgtat atgaaataaa aaaattggac   540
ggtagtttct ataaaggaac gcttatgcaa aaatggcctg tccgcaaggc gcgtcctgtt   600
tctaaacgtt taattccaga agaaccatta atcacaggtc aacgagttat tgatgcattc   660
tttccagtaa ccaaaggggg agctgcagca gttcctggac cgtttggagc aggaaagaca   720
gttgtacaac accaagtagc taaatttgcc aatgttgata ttgttattta tgtcggttgt   780
ggagaacgtg gaaatgaaat gacggatgta ctgaatgagt ttcctgagtt gattgaccct   840
aataccggac aatcaattat gcaacggaca gttctgattg ctaatacttc aaatatgcct   900
gttgctgctc gtgaggcttc aatttataca ggaattacca tggctgagta ttttcgtgat   960
atgggctact ctgtcgccat tatggctgat tcaacttcac gttgggcaga agcgctacgt   1020
gaaatgtcag gacgtctaga agaaatgcct ggtgatgagg gttatcctgc ttatctggga   1080
agtcgtatcg ctgaatatta tgaaagagca ggacgttctc aggttctagg gcttccagaa   1140
cgtgaaggaa cgattactgc tattggagct gtatcgccac ctggtggaga tatttcagaa   1200
ccagttactc aaaacacttt acggattgtg aaagtttttt gggggcttga tgctccgttg   1260
gcacagcgac gtcattttcc tgcaattaac tggcttacat cttattcact atataaagac   1320
agtgtgggca cttatataga tggtaaagag aagacagatt ggaatagtaa aataactcgt   1380
gcgatgaact acttacaacg ggaatctagt ttagaggaaa ttgttcgtct tgttggaatt   1440
gattctctgt ctgataatga acgactaacg atggaaattg ctaaacaaat tcgagaagat   1500
tatttgcaac agaacgcttt tgattcggta gatacattca cttcgtttgc aaaacaagaa   1560
gcaatgctaa gtaatattct cacttttgct gatcaggcaa atcatgcttt agagttgggt   1620
tcttacttta cagagattat ggaaggtacc gtggcagttc gagaccgtat ggcgagaagt   1680
aaatatgttt cagaagatag attagatgaa atcaaaatta tatcaaatga gattacacat   1740
caaattcatt tgatattaga aacaggaggt cta                                1773

<210>   2664
<211>   591
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   v-type sodium ATP synthase, subunit A (ntpA)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903403 (3.E-30)

<400>   2664
Met Thr Gln Gly Lys Ile Ile Lys Val Ser Gly Pro Leu Val Ile Ala 
1               5                   10                  15      

Ser Gly Met Gln Glu Ala Asn Ile Gln Asp Ile Cys Arg Val Gly Lys 
            20                  25                  30          

Leu Gly Leu Ile Gly Glu Ile Ile Glu Met Arg Arg Asp Gln Ala Ser 
        35                  40                  45              

Ile Gln Val Tyr Glu Glu Thr Ser Gly Leu Gly Pro Gly Glu Pro Val 
    50                  55                  60                  

Val Thr Thr Gly Glu Pro Leu Ser Val Glu Leu Gly Pro Gly Leu Ile 
65                  70                  75                  80  

Ser Gln Met Phe Asp Gly Ile Gln Arg Pro Leu Asp Arg Phe Lys Leu 
                85                  90                  95      

Ala Thr His Asn Asp Phe Leu Val Arg Gly Val Glu Val Pro Ser Leu 
            100                 105                 110         

Asp Arg Asp Ile Lys Trp His Phe Asp Ser Thr Ile Ala Ile Gly Gln 
        115                 120                 125             

Lys Val Ser Thr Gly Asp Ile Leu Gly Thr Val Lys Glu Thr Glu Val 
    130                 135                 140                 

Val Asn His Lys Ile Met Val Pro Tyr Gly Val Ser Gly Glu Val Val 
145                 150                 155                 160 


Ser Ile Ala Ser Gly Asp Phe Thr Ile Asp Glu Val Val Tyr Glu Ile 
                165                 170                 175     

Lys Lys Leu Asp Gly Ser Phe Tyr Lys Gly Thr Leu Met Gln Lys Trp 
            180                 185                 190         

Pro Val Arg Lys Ala Arg Pro Val Ser Lys Arg Leu Ile Pro Glu Glu 
        195                 200                 205             

Pro Leu Ile Thr Gly Gln Arg Val Ile Asp Ala Phe Phe Pro Val Thr 
    210                 215                 220                 

Lys Gly Gly Ala Ala Ala Val Pro Gly Pro Phe Gly Ala Gly Lys Thr 
225                 230                 235                 240 

Val Val Gln His Gln Val Ala Lys Phe Ala Asn Val Asp Ile Val Ile 
                245                 250                 255     

Tyr Val Gly Cys Gly Glu Arg Gly Asn Glu Met Thr Asp Val Leu Asn 
            260                 265                 270         

Glu Phe Pro Glu Leu Ile Asp Pro Asn Thr Gly Gln Ser Ile Met Gln 
        275                 280                 285             

Arg Thr Val Leu Ile Ala Asn Thr Ser Asn Met Pro Val Ala Ala Arg 
    290                 295                 300                 

Glu Ala Ser Ile Tyr Thr Gly Ile Thr Met Ala Glu Tyr Phe Arg Asp 
305                 310                 315                 320 

Met Gly Tyr Ser Val Ala Ile Met Ala Asp Ser Thr Ser Arg Trp Ala 
                325                 330                 335     

Glu Ala Leu Arg Glu Met Ser Gly Arg Leu Glu Glu Met Pro Gly Asp 
            340                 345                 350         

Glu Gly Tyr Pro Ala Tyr Leu Gly Ser Arg Ile Ala Glu Tyr Tyr Glu 
        355                 360                 365             

Arg Ala Gly Arg Ser Gln Val Leu Gly Leu Pro Glu Arg Glu Gly Thr 
    370                 375                 380                 

Ile Thr Ala Ile Gly Ala Val Ser Pro Pro Gly Gly Asp Ile Ser Glu 
385                 390                 395                 400 

Pro Val Thr Gln Asn Thr Leu Arg Ile Val Lys Val Phe Trp Gly Leu 
                405                 410                 415     

Asp Ala Pro Leu Ala Gln Arg Arg His Phe Pro Ala Ile Asn Trp Leu 
            420                 425                 430         

Thr Ser Tyr Ser Leu Tyr Lys Asp Ser Val Gly Thr Tyr Ile Asp Gly 
        435                 440                 445             

Lys Glu Lys Thr Asp Trp Asn Ser Lys Ile Thr Arg Ala Met Asn Tyr 
    450                 455                 460                 

Leu Gln Arg Glu Ser Ser Leu Glu Glu Ile Val Arg Leu Val Gly Ile 
465                 470                 475                 480 

Asp Ser Leu Ser Asp Asn Glu Arg Leu Thr Met Glu Ile Ala Lys Gln 
                485                 490                 495     

Ile Arg Glu Asp Tyr Leu Gln Gln Asn Ala Phe Asp Ser Val Asp Thr 
            500                 505                 510         

Phe Thr Ser Phe Ala Lys Gln Glu Ala Met Leu Ser Asn Ile Leu Thr 
        515                 520                 525             

Phe Ala Asp Gln Ala Asn His Ala Leu Glu Leu Gly Ser Tyr Phe Thr 
    530                 535                 540                 

Glu Ile Met Glu Gly Thr Val Ala Val Arg Asp Arg Met Ala Arg Ser 
545                 550                 555                 560 

Lys Tyr Val Ser Glu Asp Arg Leu Asp Glu Ile Lys Ile Ile Ser Asn 
                565                 570                 575     

Glu Ile Thr His Gln Ile His Leu Ile Leu Glu Thr Gly Gly Leu 
            580                 585                 590     

<210>   2665
<211>   318
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2665
atggaagcta ataagtataa aattggcata attggtagcc gtgatattat tttaccattt   60
agcatgattg ggtttgatat atttcctgcc taccaagaac aagaagctat aaatacacta   120
agaaaattag ctcaatctga ttatggtgtc atttatatca ctgaagacat tgcttcaatg   180
atattagata caattcgcca ttatgattcc caagttgtgc ctgctattat tttattaccg   240
actcataaac aaggtttaaa tttaggatta aaacgtatag aggataatgt agagaaagca   300
gtaggacaca atatttta                                                 318

<210>   2666
<211>   106
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   v-type sodium ATP synthase, subunit G (ntpG)
<223>   Cellular location: cytoplasm

<400>   2666
Met Glu Ala Asn Lys Tyr Lys Ile Gly Ile Ile Gly Ser Arg Asp Ile 
1               5                   10                  15      

Ile Leu Pro Phe Ser Met Ile Gly Phe Asp Ile Phe Pro Ala Tyr Gln 
            20                  25                  30          

Glu Gln Glu Ala Ile Asn Thr Leu Arg Lys Leu Ala Gln Ser Asp Tyr 
        35                  40                  45              

Gly Val Ile Tyr Ile Thr Glu Asp Ile Ala Ser Met Ile Leu Asp Thr 
    50                  55                  60                  

Ile Arg His Tyr Asp Ser Gln Val Val Pro Ala Ile Ile Leu Leu Pro 
65                  70                  75                  80  

Thr His Lys Gln Gly Leu Asn Leu Gly Leu Lys Arg Ile Glu Asp Asn 
                85                  90                  95      

Val Glu Lys Ala Val Gly His Asn Ile Leu 
            100                 105     

<210>   2667
<211>   1005
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2667
atggatacta atcttttttc aaaaataaat acgacgattt cggtaaaaga aaacgatttt   60
attacagaag aaaaatttca aaaaattata caatccaaag atacggagac attggcattt   120
atcttagaat caactcccta tcatttatcg attgacatct tagaagatcc tagtcagaca   180
gagatttcgc taatgacaaa attagtcaat gattatagat gggcctatgc tgaaagtccg   240
tctgatataa ttgtgacttt atttgcttta cgatatgttt atcataatat caaagtttta   300
ttaaaatcta aggcggcaat taagaaagat ttttctaaat tattaattcc aatagggatt   360
tttgatatag aaagtttaaa acatttagtt tcttccttac attcagatac acttcctgat   420
tttatggttc gtgaagtaga atcaatttgg aatgagtatg aaacttttaa taatattcgt   480
gtacttgatg tcggagctga tctagcatat tttaaacatc tgaaactttt atctaatgag   540
ttagatgagg tactgtctca ggttattgtc gaaatgattg acttttataa tattattact   600
gtaaaacgtg gtttatctca aaataagagt catggggata ttttacaatt actttcagat   660
gaaggaagta tttctgctaa agaatttata tacattgtag aaaatcaaga aatatttgtg   720
tggttcaata aaataaatcc aagcttagat tcaatctttt caacttatga attgaagatg   780
caggacgcaa caatttcatc ttctgagtta gaatttttat gtgatttact attgtataaa   840
actttagatc aaggaaggta caatgtagag gggccgttag ttcttgctag atatttattg   900
ggatgtgagt ttgaagtaaa gaatctcaga atgatcatat cagctcttca aaatacaatt   960
ccctttgaat caataaaaga aaggatacgc ccacattatg gaagc                   1005

<210>   2668
<211>   335
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   v-type sodium ATP synthase, subunit C (ntpC)
<223>   Cellular location: cytoplasm

<400>   2668
Met Asp Thr Asn Leu Phe Ser Lys Ile Asn Thr Thr Ile Ser Val Lys 
1               5                   10                  15      

Glu Asn Asp Phe Ile Thr Glu Glu Lys Phe Gln Lys Ile Ile Gln Ser 
            20                  25                  30          

Lys Asp Thr Glu Thr Leu Ala Phe Ile Leu Glu Ser Thr Pro Tyr His 
        35                  40                  45              

Leu Ser Ile Asp Ile Leu Glu Asp Pro Ser Gln Thr Glu Ile Ser Leu 
    50                  55                  60                  

Met Thr Lys Leu Val Asn Asp Tyr Arg Trp Ala Tyr Ala Glu Ser Pro 
65                  70                  75                  80  

Ser Asp Ile Ile Val Thr Leu Phe Ala Leu Arg Tyr Val Tyr His Asn 
                85                  90                  95      

Ile Lys Val Leu Leu Lys Ser Lys Ala Ala Ile Lys Lys Asp Phe Ser 
            100                 105                 110         

Lys Leu Leu Ile Pro Ile Gly Ile Phe Asp Ile Glu Ser Leu Lys His 
        115                 120                 125             

Leu Val Ser Ser Leu His Ser Asp Thr Leu Pro Asp Phe Met Val Arg 
    130                 135                 140                 

Glu Val Glu Ser Ile Trp Asn Glu Tyr Glu Thr Phe Asn Asn Ile Arg 
145                 150                 155                 160 

Val Leu Asp Val Gly Ala Asp Leu Ala Tyr Phe Lys His Leu Lys Leu 
                165                 170                 175     

Leu Ser Asn Glu Leu Asp Glu Val Leu Ser Gln Val Ile Val Glu Met 
            180                 185                 190         

Ile Asp Phe Tyr Asn Ile Ile Thr Val Lys Arg Gly Leu Ser Gln Asn 
        195                 200                 205             

Lys Ser His Gly Asp Ile Leu Gln Leu Leu Ser Asp Glu Gly Ser Ile 
    210                 215                 220                 

Ser Ala Lys Glu Phe Ile Tyr Ile Val Glu Asn Gln Glu Ile Phe Val 
225                 230                 235                 240 

Trp Phe Asn Lys Ile Asn Pro Ser Leu Asp Ser Ile Phe Ser Thr Tyr 
                245                 250                 255     

Glu Leu Lys Met Gln Asp Ala Thr Ile Ser Ser Ser Glu Leu Glu Phe 
            260                 265                 270         

Leu Cys Asp Leu Leu Leu Tyr Lys Thr Leu Asp Gln Gly Arg Tyr Asn 
        275                 280                 285             

Val Glu Gly Pro Leu Val Leu Ala Arg Tyr Leu Leu Gly Cys Glu Phe 
    290                 295                 300                 

Glu Val Lys Asn Leu Arg Met Ile Ile Ser Ala Leu Gln Asn Thr Ile 
305                 310                 315                 320 

Pro Phe Glu Ser Ile Lys Glu Arg Ile Arg Pro His Tyr Gly Ser 
                325                 330                 335 

<210>   2669
<211>   579
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2669
atgagcaatt tagaaaactt acgagagtct gttattgaac aagctcatga aaaagggcgt   60
atgaaattat tggattccaa aaagaagatt gatgatgaat ttgaaatgca aaagtcgctc   120
attataaaga aaaaagaagc tgaacatgaa cgaaagttaa aagaattgca acagaaatat   180
caaataattt ttcaacaatt aaaaaataag gaacgccaat caacgttagt atcaaaacag   240
aaaatattaa aagaactttt tcaatctgct ttactagaaa tggaatcttg gagtgcagat   300
aaagaaatgg agttcatcta tcgaattctg gaacgatatt cacaacaaga ggtcatagta   360
acctttgggg aacggacttt agctaaattc aatttggaac aattagagaa attgaaattc   420
tcttttccaa attatttatt tagtgaacaa cctatctcaa atgaatcagg cttacttatt   480
tcaataggta aaattgatga taactatttg tataaaacat taattggatc gatttctaag   540
gaagaaagtt caagtatcgc aaatcaaatt tttatcaat                          579

<210>   2670
<211>   193
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   v-type sodium ATP synthase, subunit E (ntpE)
<223>   Cellular location: cytoplasm

<400>   2670
Met Ser Asn Leu Glu Asn Leu Arg Glu Ser Val Ile Glu Gln Ala His 
1               5                   10                  15      

Glu Lys Gly Arg Met Lys Leu Leu Asp Ser Lys Lys Lys Ile Asp Asp 
            20                  25                  30          

Glu Phe Glu Met Gln Lys Ser Leu Ile Ile Lys Lys Lys Glu Ala Glu 
        35                  40                  45              

His Glu Arg Lys Leu Lys Glu Leu Gln Gln Lys Tyr Gln Ile Ile Phe 
    50                  55                  60                  

Gln Gln Leu Lys Asn Lys Glu Arg Gln Ser Thr Leu Val Ser Lys Gln 
65                  70                  75                  80  

Lys Ile Leu Lys Glu Leu Phe Gln Ser Ala Leu Leu Glu Met Glu Ser 
                85                  90                  95      

Trp Ser Ala Asp Lys Glu Met Glu Phe Ile Tyr Arg Ile Leu Glu Arg 
            100                 105                 110         

Tyr Ser Gln Gln Glu Val Ile Val Thr Phe Gly Glu Arg Thr Leu Ala 
        115                 120                 125             

Lys Phe Asn Leu Glu Gln Leu Glu Lys Leu Lys Phe Ser Phe Pro Asn 
    130                 135                 140                 

Tyr Leu Phe Ser Glu Gln Pro Ile Ser Asn Glu Ser Gly Leu Leu Ile 
145                 150                 155                 160 

Ser Ile Gly Lys Ile Asp Asp Asn Tyr Leu Tyr Lys Thr Leu Ile Gly 
                165                 170                 175     

Ser Ile Ser Lys Glu Glu Ser Ser Ser Ile Ala Asn Gln Ile Phe Ile 
            180                 185                 190         

Asn 
    

<210>   2671
<211>   474
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2671
atggaacatt tagcaactta tttttcaacc tatggaggag ctttcttcgc tgcattggga   60
attgtattgg cggttggatt aagcggtatg gggtctgctt atggagttgg taaggctggg   120
caatctgccg cagctttact gaaagaacag cctgaaaagt ttgcctcagc tttgatattg   180
caattattgc ccggaacaca aggattatat ggttttgtta ttggaatttt aatttggttg   240
caattaactc cagaacttcc tttagaaaaa ggcgttgctt atttctttgt agctcttcca   300
attgctattg taggatactt ttcagctaag catcaaggaa atgtagcagt agcgggaatg   360
caaatcttgg ctaaaagacc aaaagaattc atgaagggag caattttagc tgccatggta   420
gaaacctatg caattcttgc ttttgtcgta tcattcattt tgacccttcg tgta         474

<210>   2672
<211>   158
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   v-type sodium ATP synthase, subunit K (ntpK)
<223>   Cellular location: membrane

<400>   2672
Met Glu His Leu Ala Thr Tyr Phe Ser Thr Tyr Gly Gly Ala Phe Phe 
1               5                   10                  15      

Ala Ala Leu Gly Ile Val Leu Ala Val Gly Leu Ser Gly Met Gly Ser 
            20                  25                  30          

Ala Tyr Gly Val Gly Lys Ala Gly Gln Ser Ala Ala Ala Leu Leu Lys 
        35                  40                  45              

Glu Gln Pro Glu Lys Phe Ala Ser Ala Leu Ile Leu Gln Leu Leu Pro 
    50                  55                  60                  

Gly Thr Gln Gly Leu Tyr Gly Phe Val Ile Gly Ile Leu Ile Trp Leu 
65                  70                  75                  80  

Gln Leu Thr Pro Glu Leu Pro Leu Glu Lys Gly Val Ala Tyr Phe Phe 
                85                  90                  95      

Val Ala Leu Pro Ile Ala Ile Val Gly Tyr Phe Ser Ala Lys His Gln 
            100                 105                 110         

Gly Asn Val Ala Val Ala Gly Met Gln Ile Leu Ala Lys Arg Pro Lys 
        115                 120                 125             

Glu Phe Met Lys Gly Ala Ile Leu Ala Ala Met Val Glu Thr Tyr Ala 
    130                 135                 140                 

Ile Leu Ala Phe Val Val Ser Phe Ile Leu Thr Leu Arg Val 
145                 150                 155             

<210>   2673
<211>   1989
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2673
atggccatta gtcagatgaa aagaatctct ctactatttt ctaaaagtag tcttgatgat   60
gttttaaaaa ctattcaaga actagagtca gtgcagttcc gtgatttaaa ggttcaggat   120
aactggtcag aagctctaga aaaagatgaa gttgtatttc caactattca aatttttcat   180
acttctaatt ccaatcatgg ggttattgag ggaaatgatg ccttgactta tttgatgaat   240
caacaacaac atttagaagc aactgtagag aaattacaag aatacctacc gaaagaaaac   300
acgtttaaat tattgcagca acctccgata actacctctt atgaagaatt agagaaattt   360
ggtaaagcta atgttgctga gggtgttctt aaaaaagtga atcatcaaat taacagagtt   420
catgaattag aaagacacat tcaaagtaat aatgaggaaa tagagcgatt aataaagtgg   480
gaaaaattag aaattgttcc tgcgaattta gaacaatttt ctttctgtaa aggaaaagtc   540
ggaacaattc caaggactga agataatcgc ttatacaata gtcttttaga aaacaatatt   600
gaagttcaag aaatattttc taatgataga gagtacggtg ttgttgtttt ctatcagtct   660
agttactcta tagattttga tgaatactta tttgaaccat ttgattattc tagaaaggaa   720
ttaccgaagc agcgagtagt agatttagat caagaaaaca tgcagttaat aactgaaaaa   780
gagaatatta tcgcatcgtt gcaagattca aagaaatatt tgatagattt acaatggcaa   840
atagactata ttttatctat ctatgctcgt caaatctcta agaataactt tttgtgcact   900
ccgcatctag ttgcattaga aggatggata gaagaaactc gtattttata ttttataaaa   960
gttatggatg agcattttgg acattctatt tatatttatg aatcggaaac attgacggat   1020
aatcaagatg aaatacctat caaattaacg aatcattctt taattgaacc atttgaatta   1080
ttgacagaaa tgtatgctct gcccaaatat tatgagaaag atcctacacc tgtattagca   1140
ccattttact ttacattttt tggaatgatg gttgctgatt taggctatgg tttactattg   1200
tttttaggaa caatgttagc attaaaaatt tttcatctac cttcagcaac taagagattt   1260
ttaaaattct ttaatatatt aggggtagcc gttgcaattt ggggtggaat ctatggctca   1320
ttttttggat atgagttgcc atttcatctg atatctacaa cctctgatgt catgactata   1380
ttagtagtgt cagttgtgtt tgggtttatt acagtatttg caggtttgtt agcttcagga   1440
ctacaaaaag taagaatgaa taaatatgca gaagcatata attcaggatt tgcgtggtgt   1500
gttattctgc ttggcttgtt atttattgct gttggaatgt tgatgcctga tatgagaccg   1560
ttatttgtat tagggaaatg ggtatctatt tttaatgctg tggggatttt gattgtttct   1620
attattcaaa ccaaaagctt gtcaggtatt ggagcaggat tgtttaatct atataacatt   1680
tcatcttata taggtgattt agttagtttc actcgattga tggcattagg attatctgga   1740
gcaagtatag catcagcttt caatttaatt gttggtttgt ttccgggaat attggctaaa   1800
ctgacaattg gattagtatt attcattctt ttacatgcga tcaatatttt tctatcgtta   1860
ctatcaggat atgttcatgg agcacgtctg atatttgttg aattttttgg taagttttat   1920
gagggtggag gaaaaccatt tcaacctttg aaggcttctg agaaatatat taaggttatt   1980
acaaagaat                                                           1989

<210>   2674
<211>   663
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   v-type sodium ATP synthase, subunit I (ntpI)
<223>   Cellular location: membrane

<400>   2674
Met Ala Ile Ser Gln Met Lys Arg Ile Ser Leu Leu Phe Ser Lys Ser 
1               5                   10                  15      

Ser Leu Asp Asp Val Leu Lys Thr Ile Gln Glu Leu Glu Ser Val Gln 
            20                  25                  30          

Phe Arg Asp Leu Lys Val Gln Asp Asn Trp Ser Glu Ala Leu Glu Lys 
        35                  40                  45              

Asp Glu Val Val Phe Pro Thr Ile Gln Ile Phe His Thr Ser Asn Ser 
    50                  55                  60                  

Asn His Gly Val Ile Glu Gly Asn Asp Ala Leu Thr Tyr Leu Met Asn 
65                  70                  75                  80  

Gln Gln Gln His Leu Glu Ala Thr Val Glu Lys Leu Gln Glu Tyr Leu 
                85                  90                  95      

Pro Lys Glu Asn Thr Phe Lys Leu Leu Gln Gln Pro Pro Ile Thr Thr 
            100                 105                 110         

Ser Tyr Glu Glu Leu Glu Lys Phe Gly Lys Ala Asn Val Ala Glu Gly 
        115                 120                 125             

Val Leu Lys Lys Val Asn His Gln Ile Asn Arg Val His Glu Leu Glu 
    130                 135                 140                 

Arg His Ile Gln Ser Asn Asn Glu Glu Ile Glu Arg Leu Ile Lys Trp 
145                 150                 155                 160 

Glu Lys Leu Glu Ile Val Pro Ala Asn Leu Glu Gln Phe Ser Phe Cys 
                165                 170                 175     

Lys Gly Lys Val Gly Thr Ile Pro Arg Thr Glu Asp Asn Arg Leu Tyr 
            180                 185                 190         

Asn Ser Leu Leu Glu Asn Asn Ile Glu Val Gln Glu Ile Phe Ser Asn 
        195                 200                 205             

Asp Arg Glu Tyr Gly Val Val Val Phe Tyr Gln Ser Ser Tyr Ser Ile 
    210                 215                 220                 

Asp Phe Asp Glu Tyr Leu Phe Glu Pro Phe Asp Tyr Ser Arg Lys Glu 
225                 230                 235                 240 

Leu Pro Lys Gln Arg Val Val Asp Leu Asp Gln Glu Asn Met Gln Leu 
                245                 250                 255     

Ile Thr Glu Lys Glu Asn Ile Ile Ala Ser Leu Gln Asp Ser Lys Lys 
            260                 265                 270         

Tyr Leu Ile Asp Leu Gln Trp Gln Ile Asp Tyr Ile Leu Ser Ile Tyr 
        275                 280                 285             

Ala Arg Gln Ile Ser Lys Asn Asn Phe Leu Cys Thr Pro His Leu Val 
    290                 295                 300                 

Ala Leu Glu Gly Trp Ile Glu Glu Thr Arg Ile Leu Tyr Phe Ile Lys 
305                 310                 315                 320 

Val Met Asp Glu His Phe Gly His Ser Ile Tyr Ile Tyr Glu Ser Glu 
                325                 330                 335     

Thr Leu Thr Asp Asn Gln Asp Glu Ile Pro Ile Lys Leu Thr Asn His 
            340                 345                 350         

Ser Leu Ile Glu Pro Phe Glu Leu Leu Thr Glu Met Tyr Ala Leu Pro 
        355                 360                 365             

Lys Tyr Tyr Glu Lys Asp Pro Thr Pro Val Leu Ala Pro Phe Tyr Phe 
    370                 375                 380                 

Thr Phe Phe Gly Met Met Val Ala Asp Leu Gly Tyr Gly Leu Leu Leu 
385                 390                 395                 400 

Phe Leu Gly Thr Met Leu Ala Leu Lys Ile Phe His Leu Pro Ser Ala 
                405                 410                 415     

Thr Lys Arg Phe Leu Lys Phe Phe Asn Ile Leu Gly Val Ala Val Ala 
            420                 425                 430         

Ile Trp Gly Gly Ile Tyr Gly Ser Phe Phe Gly Tyr Glu Leu Pro Phe 
        435                 440                 445             

His Leu Ile Ser Thr Thr Ser Asp Val Met Thr Ile Leu Val Val Ser 
    450                 455                 460                 

Val Val Phe Gly Phe Ile Thr Val Phe Ala Gly Leu Leu Ala Ser Gly 
465                 470                 475                 480 

Leu Gln Lys Val Arg Met Asn Lys Tyr Ala Glu Ala Tyr Asn Ser Gly 
                485                 490                 495     

Phe Ala Trp Cys Val Ile Leu Leu Gly Leu Leu Phe Ile Ala Val Gly 
            500                 505                 510         

Met Leu Met Pro Asp Met Arg Pro Leu Phe Val Leu Gly Lys Trp Val 
        515                 520                 525             

Ser Ile Phe Asn Ala Val Gly Ile Leu Ile Val Ser Ile Ile Gln Thr 
    530                 535                 540                 

Lys Ser Leu Ser Gly Ile Gly Ala Gly Leu Phe Asn Leu Tyr Asn Ile 
545                 550                 555                 560 

Ser Ser Tyr Ile Gly Asp Leu Val Ser Phe Thr Arg Leu Met Ala Leu 
                565                 570                 575     

Gly Leu Ser Gly Ala Ser Ile Ala Ser Ala Phe Asn Leu Ile Val Gly 
            580                 585                 590         

Leu Phe Pro Gly Ile Leu Ala Lys Leu Thr Ile Gly Leu Val Leu Phe 
        595                 600                 605             

Ile Leu Leu His Ala Ile Asn Ile Phe Leu Ser Leu Leu Ser Gly Tyr 
    610                 615                 620                 

Val His Gly Ala Arg Leu Ile Phe Val Glu Phe Phe Gly Lys Phe Tyr 
625                 630                 635                 640 

Glu Gly Gly Gly Lys Pro Phe Gln Pro Leu Lys Ala Ser Glu Lys Tyr 
                645                 650                 655     

Ile Lys Val Ile Thr Lys Asn 
            660             

<210>   2675
<211>   321
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2675
atgactaact ctgtattttc gacaatgcaa gatattgaga atgttgcaac cgatattata   60
aaatcatatg ataatgagat ttatacttat aaagctgttt cccaagaaga attggaaaaa   120
ctagaaaaaa gttatgatga aaaaagtcac gaagaattag tttcaataga aagcaattta   180
gaaatgaaac aacagaacct tattgatgag gttaataaaa caatcaagga aaatgatgca   240
aatattcagt atatttcatc aagtaggaga ggagaatttg tagaaaaaat tattggtagg   300
gtggtagaaa aatatggcca t                                             321

<210>   2676
<211>   107
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2676
Met Thr Asn Ser Val Phe Ser Thr Met Gln Asp Ile Glu Asn Val Ala 
1               5                   10                  15      

Thr Asp Ile Ile Lys Ser Tyr Asp Asn Glu Ile Tyr Thr Tyr Lys Ala 
            20                  25                  30          

Val Ser Gln Glu Glu Leu Glu Lys Leu Glu Lys Ser Tyr Asp Glu Lys 
        35                  40                  45              

Ser His Glu Glu Leu Val Ser Ile Glu Ser Asn Leu Glu Met Lys Gln 
    50                  55                  60                  

Gln Asn Leu Ile Asp Glu Val Asn Lys Thr Ile Lys Glu Asn Asp Ala 
65                  70                  75                  80  

Asn Ile Gln Tyr Ile Ser Ser Ser Arg Arg Gly Glu Phe Val Glu Lys 
                85                  90                  95      

Ile Ile Gly Arg Val Val Glu Lys Tyr Gly His 
            100                 105         

<210>   2677
<211>   888
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2677
atgaagatta taggtatcga tattggcgga acaacaatta aggcagattt atacgatgag   60
tttggaacga gtttgaatca tttcaaagag atagaaacaa ttattgacta tgatttggga   120
acgaatcaga tattaaatca ggtctgtgat ttaattggtg agtatacttt aaatcattca   180
attgatggtg ttgggatttc cactgctgga gttgttaatg ctaatactgg agaaatcatc   240
tatgcaggct atacaatacc agggtatatc ggagtaaact ttactgccga aatagaaaaa   300
cgttttgggt tgtatacttt tgttgaaaat gatgttaatt gtgctgcatt aggtgaattg   360
tggaagggac aagccaaaga taagaaaaat gtagtaatgg ttactattgg aacaggtata   420
ggaggcagta ttattgtcaa cggacaaatt gttaacggat ttaactatac tgctggtgaa   480
gtaggttata ttcctgtagg taattcggat tggcaaagta aagcctcaac aaccgcattg   540
attcatttat atcaaaaaaa gagcttgaaa actaatcaaa ctggacgtac tttcttcact   600
gatttaagat ctggagataa agttgctgaa gaaacttttg aaatttttgt agaaaatcta   660
acaaaaggtt tattaacgat ttcttatcta cttaatccag aaattctcat attaggaggt   720
gggattctgg atagtaagga tattttgtta cctgaaattc aaagttcttt agctaaaaat   780
gcaatggata ataggttttt acctaaaaat cttgtggcag ctacattagg aaatgaagct   840
ggtcgtatag gagctgtaaa aaatttctta gatagaattt ctaataaa                888

<210>   2678
<211>   296
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ROK family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903562 (2.E-47)

<400>   2678
Met Lys Ile Ile Gly Ile Asp Ile Gly Gly Thr Thr Ile Lys Ala Asp 
1               5                   10                  15      

Leu Tyr Asp Glu Phe Gly Thr Ser Leu Asn His Phe Lys Glu Ile Glu 
            20                  25                  30          

Thr Ile Ile Asp Tyr Asp Leu Gly Thr Asn Gln Ile Leu Asn Gln Val 
        35                  40                  45              

Cys Asp Leu Ile Gly Glu Tyr Thr Leu Asn His Ser Ile Asp Gly Val 
    50                  55                  60                  

Gly Ile Ser Thr Ala Gly Val Val Asn Ala Asn Thr Gly Glu Ile Ile 
65                  70                  75                  80  

Tyr Ala Gly Tyr Thr Ile Pro Gly Tyr Ile Gly Val Asn Phe Thr Ala 
                85                  90                  95      

Glu Ile Glu Lys Arg Phe Gly Leu Tyr Thr Phe Val Glu Asn Asp Val 
            100                 105                 110         

Asn Cys Ala Ala Leu Gly Glu Leu Trp Lys Gly Gln Ala Lys Asp Lys 
        115                 120                 125             

Lys Asn Val Val Met Val Thr Ile Gly Thr Gly Ile Gly Gly Ser Ile 
    130                 135                 140                 

Ile Val Asn Gly Gln Ile Val Asn Gly Phe Asn Tyr Thr Ala Gly Glu 
145                 150                 155                 160 

Val Gly Tyr Ile Pro Val Gly Asn Ser Asp Trp Gln Ser Lys Ala Ser 
                165                 170                 175     

Thr Thr Ala Leu Ile His Leu Tyr Gln Lys Lys Ser Leu Lys Thr Asn 
            180                 185                 190         

Gln Thr Gly Arg Thr Phe Phe Thr Asp Leu Arg Ser Gly Asp Lys Val 
        195                 200                 205             

Ala Glu Glu Thr Phe Glu Ile Phe Val Glu Asn Leu Thr Lys Gly Leu 
    210                 215                 220                 

Leu Thr Ile Ser Tyr Leu Leu Asn Pro Glu Ile Leu Ile Leu Gly Gly 
225                 230                 235                 240 

Gly Ile Leu Asp Ser Lys Asp Ile Leu Leu Pro Glu Ile Gln Ser Ser 
                245                 250                 255     

Leu Ala Lys Asn Ala Met Asp Asn Arg Phe Leu Pro Lys Asn Leu Val 
            260                 265                 270         

Ala Ala Thr Leu Gly Asn Glu Ala Gly Arg Ile Gly Ala Val Lys Asn 
        275                 280                 285             

Phe Leu Asp Arg Ile Ser Asn Lys 
    290                 295     

<210>   2679
<211>   1137
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2679
ttgaaaatat ataaaaagag gataaaaatt atggtaaatt acggtattgt tggagctgga   60
tattttggag ctgatttagc tcgctcaatg aacaaaattg aagatgcaaa agtggttgcg   120
gtatttgacc caaatcatgg agaagaagtt gctcaagagt tgggatcaga tgtttgtgca   180
agtttagatg aacttgtagc acgtgaagat attgattgtg tgatcgtagc ttcacctagc   240
taccttcacc gtgaaccagt tgtgaaagct gctcaacatg gcaaacacgt attttgtgaa   300
aagccaattg cattgtctta tgaagattgt aaagccatgg ttgacgcatg taaagaaaat   360
aatgtcatct ttatggctgg tcacatcatg aacttcttta acggtgtaca ccatgctaaa   420
gaattgatta ctcaaggtaa aatcggtaaa gttctttatt gccatgctgc tcgtacaggt   480
tgggaagaac aacaaccaac tgtatcatgg aagaaacttc gttctcaatc tggaggacat   540
ttgtaccacc atattcatga attagattgc attcagttta tcatgggagg acttcctgaa   600
aaagcgacaa tggtaggagg caatgtatat cataaaggtg aaaactttgg tgatgaagat   660
gatatgctca ttgtaaactt agaatactct gatgatcgtt atgctgtttt ggaatatggt   720
aatgctttcc gttggggtga acactacgtc ttgattcaag gaactgaagg agctatcaaa   780
cttgacttgt tcaatactgg cggtactctt cgtgttaaag gtgaaggaga atcacacttc   840
ttagttcatg aaactcaaga ggaagatgat gatcgtacag ctatctatac cggtcgtggt   900
atggatggag caattgcgta cggtaaacca ggagtacgtt gcccattatg gttgcaaaca   960
tgtattgata aagaaatgga atatctacat gacatcatta aaggtggaga aattacagaa   1020
gaatttgaaa aacttctcaa tggtgtagct gctttagaat caatcgctac cgctgatgca   1080
tgtactttat cagttaaaga agatcgaaaa gtaagtcttt cagaaatcac aaatgct      1137

<210>   2680
<211>   379
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   oxidoreductase, Gfo/Idh/MocA family
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903573 (e-161)

<400>   2680
Met Lys Ile Tyr Lys Lys Arg Ile Lys Ile Met Val Asn Tyr Gly Ile 
1               5                   10                  15      

Val Gly Ala Gly Tyr Phe Gly Ala Asp Leu Ala Arg Ser Met Asn Lys 
            20                  25                  30          

Ile Glu Asp Ala Lys Val Val Ala Val Phe Asp Pro Asn His Gly Glu 
        35                  40                  45              

Glu Val Ala Gln Glu Leu Gly Ser Asp Val Cys Ala Ser Leu Asp Glu 
    50                  55                  60                  

Leu Val Ala Arg Glu Asp Ile Asp Cys Val Ile Val Ala Ser Pro Ser 
65                  70                  75                  80  

Tyr Leu His Arg Glu Pro Val Val Lys Ala Ala Gln His Gly Lys His 
                85                  90                  95      

Val Phe Cys Glu Lys Pro Ile Ala Leu Ser Tyr Glu Asp Cys Lys Ala 
            100                 105                 110         

Met Val Asp Ala Cys Lys Glu Asn Asn Val Ile Phe Met Ala Gly His 
        115                 120                 125             

Ile Met Asn Phe Phe Asn Gly Val His His Ala Lys Glu Leu Ile Thr 
    130                 135                 140                 

Gln Gly Lys Ile Gly Lys Val Leu Tyr Cys His Ala Ala Arg Thr Gly 
145                 150                 155                 160 

Trp Glu Glu Gln Gln Pro Thr Val Ser Trp Lys Lys Leu Arg Ser Gln 
                165                 170                 175     

Ser Gly Gly His Leu Tyr His His Ile His Glu Leu Asp Cys Ile Gln 
            180                 185                 190         

Phe Ile Met Gly Gly Leu Pro Glu Lys Ala Thr Met Val Gly Gly Asn 
        195                 200                 205             

Val Tyr His Lys Gly Glu Asn Phe Gly Asp Glu Asp Asp Met Leu Ile 
    210                 215                 220                 

Val Asn Leu Glu Tyr Ser Asp Asp Arg Tyr Ala Val Leu Glu Tyr Gly 
225                 230                 235                 240 

Asn Ala Phe Arg Trp Gly Glu His Tyr Val Leu Ile Gln Gly Thr Glu 
                245                 250                 255     

Gly Ala Ile Lys Leu Asp Leu Phe Asn Thr Gly Gly Thr Leu Arg Val 
            260                 265                 270         

Lys Gly Glu Gly Glu Ser His Phe Leu Val His Glu Thr Gln Glu Glu 
        275                 280                 285             

Asp Asp Asp Arg Thr Ala Ile Tyr Thr Gly Arg Gly Met Asp Gly Ala 
    290                 295                 300                 

Ile Ala Tyr Gly Lys Pro Gly Val Arg Cys Pro Leu Trp Leu Gln Thr 
305                 310                 315                 320 

Cys Ile Asp Lys Glu Met Glu Tyr Leu His Asp Ile Ile Lys Gly Gly 
                325                 330                 335     

Glu Ile Thr Glu Glu Phe Glu Lys Leu Leu Asn Gly Val Ala Ala Leu 
            340                 345                 350         

Glu Ser Ile Ala Thr Ala Asp Ala Cys Thr Leu Ser Val Lys Glu Asp 
        355                 360                 365             

Arg Lys Val Ser Leu Ser Glu Ile Thr Asn Ala 
    370                 375                 

<210>   2681
<211>   2220
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2681

atgaaaaaaa atattaaaca atatgtaacc ttaggtactg tagtggtatt atcagcattt   60
gttgctaact cagttgcagc tcaggagact gaaacttctg aagtatcaac accaaagttg   120
gtgcaacctg ttgcaccaac gactccgatt tcggaagtac aacctacatc ggataactct   180
tcggaagtta ctgtacaacc tcgaacagtt gaaactactg ttaaggatcc atcttctaca   240
gcggaagaaa ctcctgtctt agaaaaaaat aatgttactt taacaggggg cggagaaaat   300
gttactaaag agttaaagga taaatttact agcggtgact ttactgtagt gattaagtac   360
aatcagtcaa gtgagaaagg cttacaagct ctgtttggaa tatctaattc caaacccggt   420
caacaaaata gttatgtaga tgtgttcctt agagacaatg gtgagttggg gatggaagcg   480
cgtgatactt cttccaataa aaataaccta gtatccagac ctgcttcagt ttggggtaag   540
tacaaacaag aggctgtgac taacactgtt gcagtagtag cagattcagt caaaaaaaca   600
tattctttat acgcaaatgg tacaaaagta gtagaaaaga aagtggataa tttcctaaac   660
atcaaggata ttaaaggtat tgattactat atgcttgggg gagtgaaacg tgcaggaaaa   720
acggcgtttg gttttaacgg aacactagaa aatatcaaat tctttaatag tgcattggat   780
gaagaaactg ttaaaaagat gacaacaaac gctgttactg gacatttaat ttatacggct   840
aatgatacaa caggttctaa ctatttccgt attccagttc tgtatacttt tagcaatggt   900
cgggtatttt caagcattga cgctcgttac ggtggaactc atgatttctt gaataaaatt   960
aatattgcta caagttatag tgatgataat ggtaagacat ggactaaacc aaaattaaca   1020
ttggcattcg atgattttgc gccagtacca ttagaatggc ctcgtgaagt tggtggacgt   1080
gacttacaaa tcagcggtgg tgcaacctat attgactctg ttattgttga aaaaaagaac   1140
aaacaagtac tcatgtttgc tgatgtgatg cctgctggag taagttttag agaagcaact   1200
agaaaagatt caggttataa acaaattgat ggtaattatt accttaaatt aaggaaacaa   1260
ggtgatactg attacaatta tactattcgt gagaatggta ctgtatacga cgatcgtacc   1320
aacagaccaa ctgaattttc agtagataaa aatttcggta ttaaacaaaa tggtaattat   1380
ttgacggtag agcaatattc ggtttcattt gaaaataata aaaagactga atatcgtaat   1440
gggactaaag tccatatgaa tatcttctac aaagatgcat tgtttaaagt agtgccaacg   1500
aactatattg catatatttc tagcaatgat catggcgaat cttggtctgc accaacttta   1560
ttacctccta taatgggact taatcggaat gcgccatatt taggtcctgg acgtggaatc   1620
attgaaagct caactggacg tattcttatt ccgtcttaca ctggtaaaga gtctgcgttc   1680
atttatagtg acgataatgg agcatcttgg aaagttaaag tagtgccact tccttctagt   1740
tggtcagcag aagcacaatt tgtagaattg agtccaggag taattcaagc atatatgcgt   1800
acaaataatg gtaaaattgc atatttaaca agtaaagacg caggtactac ttggagtgca   1860
ccggaatatt tgaaatttgt ttcaaatcca agttatggaa cacaattatc aatcatcaat   1920
tatagccaat tgattgatgg taaaaaggct gtcattttaa gtactccaaa ctccacaaat   1980
ggtcgtaaac acggacaaat ttggattggt ctaattaatg atgataatac aattgattgg   2040
cgttatcatc acgacgttga ttatagtaac tatggatact catattcaac attgacagag   2100
ttaccaaatc atgaaattgg attgatgttt gaaaaatttg attcatggtc tcgtaatgaa   2160
cttcatatga aaaatgttgt accatatata acatttaaga ttgaagatct gaaaaagaat   2220

<210>   2682
<211>   740
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   neuraminidase, putative
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903574 (0.E+01)

<400>   2682
Met Lys Lys Asn Ile Lys Gln Tyr Val Thr Leu Gly Thr Val Val Val 
1               5                   10                  15      

Leu Ser Ala Phe Val Ala Asn Ser Val Ala Ala Gln Glu Thr Glu Thr 
            20                  25                  30          

Ser Glu Val Ser Thr Pro Lys Leu Val Gln Pro Val Ala Pro Thr Thr 
        35                  40                  45              

Pro Ile Ser Glu Val Gln Pro Thr Ser Asp Asn Ser Ser Glu Val Thr 
    50                  55                  60                  

Val Gln Pro Arg Thr Val Glu Thr Thr Val Lys Asp Pro Ser Ser Thr 
65                  70                  75                  80  

Ala Glu Glu Thr Pro Val Leu Glu Lys Asn Asn Val Thr Leu Thr Gly 
                85                  90                  95      

Gly Gly Glu Asn Val Thr Lys Glu Leu Lys Asp Lys Phe Thr Ser Gly 
            100                 105                 110         

Asp Phe Thr Val Val Ile Lys Tyr Asn Gln Ser Ser Glu Lys Gly Leu 
        115                 120                 125             

Gln Ala Leu Phe Gly Ile Ser Asn Ser Lys Pro Gly Gln Gln Asn Ser 
    130                 135                 140                 

Tyr Val Asp Val Phe Leu Arg Asp Asn Gly Glu Leu Gly Met Glu Ala 
145                 150                 155                 160 

Arg Asp Thr Ser Ser Asn Lys Asn Asn Leu Val Ser Arg Pro Ala Ser 
                165                 170                 175     

Val Trp Gly Lys Tyr Lys Gln Glu Ala Val Thr Asn Thr Val Ala Val 
            180                 185                 190         

Val Ala Asp Ser Val Lys Lys Thr Tyr Ser Leu Tyr Ala Asn Gly Thr 
        195                 200                 205             

Lys Val Val Glu Lys Lys Val Asp Asn Phe Leu Asn Ile Lys Asp Ile 
    210                 215                 220                 

Lys Gly Ile Asp Tyr Tyr Met Leu Gly Gly Val Lys Arg Ala Gly Lys 
225                 230                 235                 240 

Thr Ala Phe Gly Phe Asn Gly Thr Leu Glu Asn Ile Lys Phe Phe Asn 
                245                 250                 255     

Ser Ala Leu Asp Glu Glu Thr Val Lys Lys Met Thr Thr Asn Ala Val 
            260                 265                 270         

Thr Gly His Leu Ile Tyr Thr Ala Asn Asp Thr Thr Gly Ser Asn Tyr 
        275                 280                 285             

Phe Arg Ile Pro Val Leu Tyr Thr Phe Ser Asn Gly Arg Val Phe Ser 
    290                 295                 300                 

Ser Ile Asp Ala Arg Tyr Gly Gly Thr His Asp Phe Leu Asn Lys Ile 
305                 310                 315                 320 

Asn Ile Ala Thr Ser Tyr Ser Asp Asp Asn Gly Lys Thr Trp Thr Lys 
                325                 330                 335     

Pro Lys Leu Thr Leu Ala Phe Asp Asp Phe Ala Pro Val Pro Leu Glu 
            340                 345                 350         

Trp Pro Arg Glu Val Gly Gly Arg Asp Leu Gln Ile Ser Gly Gly Ala 
        355                 360                 365             

Thr Tyr Ile Asp Ser Val Ile Val Glu Lys Lys Asn Lys Gln Val Leu 
    370                 375                 380                 

Met Phe Ala Asp Val Met Pro Ala Gly Val Ser Phe Arg Glu Ala Thr 
385                 390                 395                 400 

Arg Lys Asp Ser Gly Tyr Lys Gln Ile Asp Gly Asn Tyr Tyr Leu Lys 
                405                 410                 415     

Leu Arg Lys Gln Gly Asp Thr Asp Tyr Asn Tyr Thr Ile Arg Glu Asn 
            420                 425                 430         

Gly Thr Val Tyr Asp Asp Arg Thr Asn Arg Pro Thr Glu Phe Ser Val 
        435                 440                 445             

Asp Lys Asn Phe Gly Ile Lys Gln Asn Gly Asn Tyr Leu Thr Val Glu 
    450                 455                 460                 

Gln Tyr Ser Val Ser Phe Glu Asn Asn Lys Lys Thr Glu Tyr Arg Asn 
465                 470                 475                 480 

Gly Thr Lys Val His Met Asn Ile Phe Tyr Lys Asp Ala Leu Phe Lys 
                485                 490                 495     

Val Val Pro Thr Asn Tyr Ile Ala Tyr Ile Ser Ser Asn Asp His Gly 
            500                 505                 510         

Glu Ser Trp Ser Ala Pro Thr Leu Leu Pro Pro Ile Met Gly Leu Asn 
        515                 520                 525             

Arg Asn Ala Pro Tyr Leu Gly Pro Gly Arg Gly Ile Ile Glu Ser Ser 
    530                 535                 540                 

Thr Gly Arg Ile Leu Ile Pro Ser Tyr Thr Gly Lys Glu Ser Ala Phe 
545                 550                 555                 560 

Ile Tyr Ser Asp Asp Asn Gly Ala Ser Trp Lys Val Lys Val Val Pro 
                565                 570                 575     

Leu Pro Ser Ser Trp Ser Ala Glu Ala Gln Phe Val Glu Leu Ser Pro 
            580                 585                 590         

Gly Val Ile Gln Ala Tyr Met Arg Thr Asn Asn Gly Lys Ile Ala Tyr 
        595                 600                 605             

Leu Thr Ser Lys Asp Ala Gly Thr Thr Trp Ser Ala Pro Glu Tyr Leu 
    610                 615                 620                 

Lys Phe Val Ser Asn Pro Ser Tyr Gly Thr Gln Leu Ser Ile Ile Asn 
625                 630                 635                 640 

Tyr Ser Gln Leu Ile Asp Gly Lys Lys Ala Val Ile Leu Ser Thr Pro 
                645                 650                 655     

Asn Ser Thr Asn Gly Arg Lys His Gly Gln Ile Trp Ile Gly Leu Ile 
            660                 665                 670         

Asn Asp Asp Asn Thr Ile Asp Trp Arg Tyr His His Asp Val Asp Tyr 
        675                 680                 685             

Ser Asn Tyr Gly Tyr Ser Tyr Ser Thr Leu Thr Glu Leu Pro Asn His 
    690                 695                 700                 

Glu Ile Gly Leu Met Phe Glu Lys Phe Asp Ser Trp Ser Arg Asn Glu 
705                 710                 715                 720 

Leu His Met Lys Asn Val Val Pro Tyr Ile Thr Phe Lys Ile Glu Asp 
                725                 730                 735     

Leu Lys Lys Asn 
            740 

<210>   2683
<211>   456
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2683
atgattattt ctgaacaatc tgattttaaa cgatatgctt ctgtcaataa atatttttca   60
aaagtctgtg attttttaga aaatacaaat ttgacagatt tagttgatgg aaaaattgat   120
attgacgggg aaaatgtttt tgcaaattgt atgacttatc tagctgatgg agttccagga   180
gatatttttg aaactcataa gaaatattta gatattcata ttgttgttga aaatactgaa   240
aaaatggcag taacttcccc agttcgtgcc cagtcacgtg taccttttag cgaagagaag   300
gatattgctt tttacgatag caaagactat caaattgttg aattgcttcc agggaatatg   360
ttggtgactt ttgaagaaga tcttcaccaa ccaaagattc attgcaatga tgaaactgtt   420
aaaaaacttg ttatcaaagt tttaaacgag gaaaaa                             456

<210>   2684
<211>   152
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903578 (3.E-41)

<400>   2684
Met Ile Ile Ser Glu Gln Ser Asp Phe Lys Arg Tyr Ala Ser Val Asn 
1               5                   10                  15      

Lys Tyr Phe Ser Lys Val Cys Asp Phe Leu Glu Asn Thr Asn Leu Thr 
            20                  25                  30          

Asp Leu Val Asp Gly Lys Ile Asp Ile Asp Gly Glu Asn Val Phe Ala 
        35                  40                  45              

Asn Cys Met Thr Tyr Leu Ala Asp Gly Val Pro Gly Asp Ile Phe Glu 
    50                  55                  60                  

Thr His Lys Lys Tyr Leu Asp Ile His Ile Val Val Glu Asn Thr Glu 
65                  70                  75                  80  

Lys Met Ala Val Thr Ser Pro Val Arg Ala Gln Ser Arg Val Pro Phe 
                85                  90                  95      

Ser Glu Glu Lys Asp Ile Ala Phe Tyr Asp Ser Lys Asp Tyr Gln Ile 
            100                 105                 110         

Val Glu Leu Leu Pro Gly Asn Met Leu Val Thr Phe Glu Glu Asp Leu 
        115                 120                 125             

His Gln Pro Lys Ile His Cys Asn Asp Glu Thr Val Lys Lys Leu Val 
    130                 135                 140                 

Ile Lys Val Leu Asn Glu Glu Lys 
145                 150         

<210>   2685
<211>   1539
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2685
atgggcacaa caggatttac aataattgac ttaattatct tgattgttta tttacttgcg   60
gtgttggttg caggtatcta tttctctaaa aaagagatga aaggaaaaga gttctttaaa   120
ggagatggtt cggttccttg gtatgttact tcggtatcca tttttgccac aatgctcagt   180
ccgatttcct tcttgggact cgctggtagc tcttatgcag gtagctggat tttatggttt   240
gctcaattag ggatggtagt agctattcca ctgacaattc gttttatctt acctatcttt   300
gcacggatag acatcgatac ggcatatgat tacttggata aacgttttaa ttctaaagca   360
cttcgtatta tttcagcact cttgtttatt atttatcaat tgggacgtat gtctatcatt   420
atgtacctcc catcagctgg tttatcagta ttgacaggaa ttgacatcaa tattttgatt   480
attttgatgg gtgtagttgc aattgtttat tcttatactg gtggtctaaa atccgtatta   540
tggacagact ttattcaagg tgtgattctg attagtggtg tcgttttagc tttatttgta   600
ctgattgcta atattaaagg tggctttggt gcagtagcag aaacattagc aaacgggaaa   660
ttccttgctg caaatgaaaa acttttcgat cctaacttgc tttcaaactc catcttttta   720
attgtgatgg gttcaggctt tacaatcttg tcttcctatg cttcatctca agatttggtt   780
caacgtttta ctacaacaca aaatattaag aaacttaata agatgttgtt cacaaacggt   840
gttttgtcac ttgcaactgc aacagtcttt tacttgattg gtacaggctt gtacgtattc   900
tatcaagtac aaaatgcaga tagtgcagct agcaatatcc ctcaagacca aatctttatg   960
tactttattg cataccagtt accagtaggt atcacaggtt tgatcttggc agcgatttat   1020
gcagcatctc aatcaactat ttcaacaggt ttgaactctg ttgcaacttc atggacattg   1080
gatattcaag atgtcatttc taaaaatatg tcagacaatc gtcgtacgaa aattgcacaa   1140
ttcgtatctc tagcagtagg tttattctca attggtgttt ccattgtcat ggctcactca   1200
gatattaaat ctgcatacga atggttcaat agtttcatgg gacttgtact tggtctactt   1260
ggtggtgtat ttattcttgg atttgtttct aaaaaagcaa ataaacaagg tgcttatgca   1320
gcgctgattg tatcaaccat cgtcatggta tttattaaat acttccttcc tccaacagct   1380
gttagctact gggcatattc attgatttca atctctgtat cagtagtttc aggttatatt   1440
gtatctgttc ttactggaaa taaagtatct gcacctaaat atacaacgat tcatgatatt   1500
acagaaatta aagcggattc aagttgggaa gttcgtcac                          1539

<210>   2686
<211>   513
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sodium:solute symporter family protein
<223>   Cellular location: membrane

<400>   2686
Met Gly Thr Thr Gly Phe Thr Ile Ile Asp Leu Ile Ile Leu Ile Val 
1               5                   10                  15      

Tyr Leu Leu Ala Val Leu Val Ala Gly Ile Tyr Phe Ser Lys Lys Glu 
            20                  25                  30          

Met Lys Gly Lys Glu Phe Phe Lys Gly Asp Gly Ser Val Pro Trp Tyr 
        35                  40                  45              

Val Thr Ser Val Ser Ile Phe Ala Thr Met Leu Ser Pro Ile Ser Phe 
    50                  55                  60                  

Leu Gly Leu Ala Gly Ser Ser Tyr Ala Gly Ser Trp Ile Leu Trp Phe 
65                  70                  75                  80  

Ala Gln Leu Gly Met Val Val Ala Ile Pro Leu Thr Ile Arg Phe Ile 
                85                  90                  95      

Leu Pro Ile Phe Ala Arg Ile Asp Ile Asp Thr Ala Tyr Asp Tyr Leu 
            100                 105                 110         

Asp Lys Arg Phe Asn Ser Lys Ala Leu Arg Ile Ile Ser Ala Leu Leu 
        115                 120                 125             

Phe Ile Ile Tyr Gln Leu Gly Arg Met Ser Ile Ile Met Tyr Leu Pro 
    130                 135                 140                 

Ser Ala Gly Leu Ser Val Leu Thr Gly Ile Asp Ile Asn Ile Leu Ile 
145                 150                 155                 160 

Ile Leu Met Gly Val Val Ala Ile Val Tyr Ser Tyr Thr Gly Gly Leu 
                165                 170                 175     

Lys Ser Val Leu Trp Thr Asp Phe Ile Gln Gly Val Ile Leu Ile Ser 
            180                 185                 190         

Gly Val Val Leu Ala Leu Phe Val Leu Ile Ala Asn Ile Lys Gly Gly 
        195                 200                 205             

Phe Gly Ala Val Ala Glu Thr Leu Ala Asn Gly Lys Phe Leu Ala Ala 
    210                 215                 220                 

Asn Glu Lys Leu Phe Asp Pro Asn Leu Leu Ser Asn Ser Ile Phe Leu 
225                 230                 235                 240 

Ile Val Met Gly Ser Gly Phe Thr Ile Leu Ser Ser Tyr Ala Ser Ser 
                245                 250                 255     

Gln Asp Leu Val Gln Arg Phe Thr Thr Thr Gln Asn Ile Lys Lys Leu 
            260                 265                 270         

Asn Lys Met Leu Phe Thr Asn Gly Val Leu Ser Leu Ala Thr Ala Thr 
        275                 280                 285             

Val Phe Tyr Leu Ile Gly Thr Gly Leu Tyr Val Phe Tyr Gln Val Gln 
    290                 295                 300                 

Asn Ala Asp Ser Ala Ala Ser Asn Ile Pro Gln Asp Gln Ile Phe Met 
305                 310                 315                 320 

Tyr Phe Ile Ala Tyr Gln Leu Pro Val Gly Ile Thr Gly Leu Ile Leu 
                325                 330                 335     

Ala Ala Ile Tyr Ala Ala Ser Gln Ser Thr Ile Ser Thr Gly Leu Asn 
            340                 345                 350         

Ser Val Ala Thr Ser Trp Thr Leu Asp Ile Gln Asp Val Ile Ser Lys 
        355                 360                 365             

Asn Met Ser Asp Asn Arg Arg Thr Lys Ile Ala Gln Phe Val Ser Leu 
    370                 375                 380                 

Ala Val Gly Leu Phe Ser Ile Gly Val Ser Ile Val Met Ala His Ser 
385                 390                 395                 400 

Asp Ile Lys Ser Ala Tyr Glu Trp Phe Asn Ser Phe Met Gly Leu Val 
                405                 410                 415     

Leu Gly Leu Leu Gly Gly Val Phe Ile Leu Gly Phe Val Ser Lys Lys 
            420                 425                 430         

Ala Asn Lys Gln Gly Ala Tyr Ala Ala Leu Ile Val Ser Thr Ile Val 
        435                 440                 445             

Met Val Phe Ile Lys Tyr Phe Leu Pro Pro Thr Ala Val Ser Tyr Trp 
    450                 455                 460                 

Ala Tyr Ser Leu Ile Ser Ile Ser Val Ser Val Val Ser Gly Tyr Ile 
465                 470                 475                 480 

Val Ser Val Leu Thr Gly Asn Lys Val Ser Ala Pro Lys Tyr Thr Thr 
                485                 490                 495     

Ile His Asp Ile Thr Glu Ile Lys Ala Asp Ser Ser Trp Glu Val Arg 
            500                 505                 510         

His 
    

<210>   2687
<211>   915
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2687
atgaaagatt taactaaata caaaggcgtt atccctgcat tttatgcttg ctatgatgaa   60
aatggtgaaa ttagccaaga tcgtgtaaaa tctctggtac aatatttcat tgacaaaggt   120
gtaaaaggta tctatgtaaa tggttcttca ggtgaatgta tttaccaaag tgtagaagat   180
cgtaaacaaa ttattgaagc tgttatggaa gttgctaaag gtaaattaac agttatcaac   240
catattgcat gtaataacac gaaagatagt atcgaattgg caaaacattc agaaagtgtt   300
ggagtcgatg ctattgcagc tatcccacct atttatttca aattgccaga gtattcaatc   360
gcagcatatt ggaatgcaat gagtgaagct gcgtcaaata cagattttat tatctataat   420
attccacaat tggcaggggt tgcgttgact ggtagtttgt atgcaacaat gcgtcaaaat   480
cctcgtgtga ttggagttaa aaattcttct atgcctgtac aagatattca aatgtttgta   540
gctgcaggtg gagaagatta cattgtattc aatggtccag atgaacaata tcttggtggt   600
cgcttgatgg gagcagaagc tggtattggt ggtacttatg gcgttatgcc agatttgttc   660
ttgaaattgg aaagtttgat tcaagaacga gatttagata cagctaaaaa acttcaatat   720
gctatcaatg aagttatcta taagatgata tcaggtaagg caaatatgta tgctgtagca   780
aaagaagttt tgcgtctaaa tgaaaaactt gatttaggtt ctgttcgtca acctttagaa   840
gcattggcag aaggtgactt ggaagttgca aaacaagcag cagaacttat tcaacaagca   900
cgaaaagaat tttta                                                    915

<210>   2688
<211>   305
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   N-acetylneuraminate lyase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903563 (8.E-97)

<400>   2688
Met Lys Asp Leu Thr Lys Tyr Lys Gly Val Ile Pro Ala Phe Tyr Ala 
1               5                   10                  15      

Cys Tyr Asp Glu Asn Gly Glu Ile Ser Gln Asp Arg Val Lys Ser Leu 
            20                  25                  30          

Val Gln Tyr Phe Ile Asp Lys Gly Val Lys Gly Ile Tyr Val Asn Gly 
        35                  40                  45              

Ser Ser Gly Glu Cys Ile Tyr Gln Ser Val Glu Asp Arg Lys Gln Ile 
    50                  55                  60                  

Ile Glu Ala Val Met Glu Val Ala Lys Gly Lys Leu Thr Val Ile Asn 
65                  70                  75                  80  

His Ile Ala Cys Asn Asn Thr Lys Asp Ser Ile Glu Leu Ala Lys His 
                85                  90                  95      

Ser Glu Ser Val Gly Val Asp Ala Ile Ala Ala Ile Pro Pro Ile Tyr 
            100                 105                 110         

Phe Lys Leu Pro Glu Tyr Ser Ile Ala Ala Tyr Trp Asn Ala Met Ser 
        115                 120                 125             

Glu Ala Ala Ser Asn Thr Asp Phe Ile Ile Tyr Asn Ile Pro Gln Leu 
    130                 135                 140                 

Ala Gly Val Ala Leu Thr Gly Ser Leu Tyr Ala Thr Met Arg Gln Asn 
145                 150                 155                 160 

Pro Arg Val Ile Gly Val Lys Asn Ser Ser Met Pro Val Gln Asp Ile 
                165                 170                 175     

Gln Met Phe Val Ala Ala Gly Gly Glu Asp Tyr Ile Val Phe Asn Gly 
            180                 185                 190         

Pro Asp Glu Gln Tyr Leu Gly Gly Arg Leu Met Gly Ala Glu Ala Gly 
        195                 200                 205             

Ile Gly Gly Thr Tyr Gly Val Met Pro Asp Leu Phe Leu Lys Leu Glu 
    210                 215                 220                 

Ser Leu Ile Gln Glu Arg Asp Leu Asp Thr Ala Lys Lys Leu Gln Tyr 
225                 230                 235                 240 

Ala Ile Asn Glu Val Ile Tyr Lys Met Ile Ser Gly Lys Ala Asn Met 
                245                 250                 255     

Tyr Ala Val Ala Lys Glu Val Leu Arg Leu Asn Glu Lys Leu Asp Leu 
            260                 265                 270         

Gly Ser Val Arg Gln Pro Leu Glu Ala Leu Ala Glu Gly Asp Leu Glu 
        275                 280                 285             

Val Ala Lys Gln Ala Ala Glu Leu Ile Gln Gln Ala Arg Lys Glu Phe 
    290                 295                 300                 

Leu 
305 

<210>   2689
<211>   699
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2689
atgagccaaa tttggactaa agaaaaattt ataagccaag ttcaaggtgg agtcattgtt   60
tcttgtcaag ctttacctgg tgaagccctt tataatgaag aatttagctt gatgcctttt   120
atggctaaag cagctttaga ggcaggagca gtgggcattc gcgcaaattc tgtgcgtgat   180
attaaagcaa ttcagaaagt agtagattta ccaataattg gaattatcaa aagggattat   240
ccacctcaag aaccatatat tactgctacg atgaaagaag tagatgaact tgtagaatgc   300
ggaacaacag tcattgcatt tgatgcaact ttaagaccaa gatatgatgg cttagttgtc   360
agtgaattta tcaaaaaaat aaaagaaaaa tatccgaatc aattgctgat ggcggatgta   420
agtaatttag atgaaggtct ctatgcattt aaatcaggcg ttgattttgt tggtacaaca   480
ttatcaggtt acacaagtac aagtgtacaa tcagatgagc ctgattttga actaatgaaa   540
aaattggctg attttaatat tccggtaatt gccgaaggaa aaattcatta tccagaacaa   600
ttaaaaaaag cttatagttt aggtgttacc agtgtagtca ttggtggagc gattacacgt   660
ccaaaagaaa ttgctcagcg atttattaat gtcatcaaa                          699

<210>   2690
<211>   233
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   N-acetylmannosamine-6-P epimerase, putative (nanE)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903572 (9.E-82)

<400>   2690
Met Ser Gln Ile Trp Thr Lys Glu Lys Phe Ile Ser Gln Val Gln Gly 
1               5                   10                  15      

Gly Val Ile Val Ser Cys Gln Ala Leu Pro Gly Glu Ala Leu Tyr Asn 
            20                  25                  30          

Glu Glu Phe Ser Leu Met Pro Phe Met Ala Lys Ala Ala Leu Glu Ala 
        35                  40                  45              

Gly Ala Val Gly Ile Arg Ala Asn Ser Val Arg Asp Ile Lys Ala Ile 
    50                  55                  60                  

Gln Lys Val Val Asp Leu Pro Ile Ile Gly Ile Ile Lys Arg Asp Tyr 
65                  70                  75                  80  

Pro Pro Gln Glu Pro Tyr Ile Thr Ala Thr Met Lys Glu Val Asp Glu 
                85                  90                  95      

Leu Val Glu Cys Gly Thr Thr Val Ile Ala Phe Asp Ala Thr Leu Arg 
            100                 105                 110         

Pro Arg Tyr Asp Gly Leu Val Val Ser Glu Phe Ile Lys Lys Ile Lys 
        115                 120                 125             

Glu Lys Tyr Pro Asn Gln Leu Leu Met Ala Asp Val Ser Asn Leu Asp 
    130                 135                 140                 

Glu Gly Leu Tyr Ala Phe Lys Ser Gly Val Asp Phe Val Gly Thr Thr 
145                 150                 155                 160 

Leu Ser Gly Tyr Thr Ser Thr Ser Val Gln Ser Asp Glu Pro Asp Phe 
                165                 170                 175     

Glu Leu Met Lys Lys Leu Ala Asp Phe Asn Ile Pro Val Ile Ala Glu 
            180                 185                 190         

Gly Lys Ile His Tyr Pro Glu Gln Leu Lys Lys Ala Tyr Ser Leu Gly 
        195                 200                 205             

Val Thr Ser Val Val Ile Gly Gly Ala Ile Thr Arg Pro Lys Glu Ile 
    210                 215                 220                 

Ala Gln Arg Phe Ile Asn Val Ile Lys 
225                 230             

<210>   2691
<211>   807
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2691
atgttactgc aaaaagaact aattccaatg atagaagcta acttaccaaa tatggcatat   60
gctgaaaaag acattgctaa attcttctta aaacagcaac ctctgaatga ttattcatct   120
aaagcattgt gcgaatacct taatgtatcc aaagcaacat tgactcgatt tgcgaaaaaa   180
tgtggtttta aaggttttag acaattcatt ttcaaatacc aagagatgat tcatgagaaa   240
gaaaagttgg cattatatac agaggcaaca gaaaaagttt tatccgacta tgaggaaatg   300
ttgagaaaaa cttacacggt tcttgatgaa gttcaacttg agcgtattgc tgagatgata   360
gaaactgctg agcgtgtata tctctacggt aaaggaagtt ctgttcttgc tttacaagaa   420
atgaagatga gatttatgcg tctcggagtg attggtgaag tattatcaga cgaggatatg   480
attttgtgga gtagcttact acttaatgaa aattgccttg tcattggagc atccatttca   540
ggtcaaactg atattgtact agaaggtcta caaaaagctg cagataaagg cgctaaaaca   600
gttttaatga ctacaagaaa atttgacgaa gaagattgtt tctttgatga actattgtta   660
ttagcttcga ccgatcatct ctcgtatggc aatcgcatat cacctcagtt tccaatactt   720
ttaattacag actgcttatt ctctaattat ctggaaagtc cagagagaca atattattac   780
aatcaaacta ttatccataa ggaggaa                                       807

<210>   2692
<211>   269
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphosugar-binding transcriptional regulator, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903561 (1.E-54)

<400>   2692
Met Leu Leu Gln Lys Glu Leu Ile Pro Met Ile Glu Ala Asn Leu Pro 
1               5                   10                  15      

Asn Met Ala Tyr Ala Glu Lys Asp Ile Ala Lys Phe Phe Leu Lys Gln 
            20                  25                  30          

Gln Pro Leu Asn Asp Tyr Ser Ser Lys Ala Leu Cys Glu Tyr Leu Asn 
        35                  40                  45              

Val Ser Lys Ala Thr Leu Thr Arg Phe Ala Lys Lys Cys Gly Phe Lys 
    50                  55                  60                  

Gly Phe Arg Gln Phe Ile Phe Lys Tyr Gln Glu Met Ile His Glu Lys 
65                  70                  75                  80  

Glu Lys Leu Ala Leu Tyr Thr Glu Ala Thr Glu Lys Val Leu Ser Asp 
                85                  90                  95      

Tyr Glu Glu Met Leu Arg Lys Thr Tyr Thr Val Leu Asp Glu Val Gln 
            100                 105                 110         

Leu Glu Arg Ile Ala Glu Met Ile Glu Thr Ala Glu Arg Val Tyr Leu 
        115                 120                 125             

Tyr Gly Lys Gly Ser Ser Val Leu Ala Leu Gln Glu Met Lys Met Arg 
    130                 135                 140                 

Phe Met Arg Leu Gly Val Ile Gly Glu Val Leu Ser Asp Glu Asp Met 
145                 150                 155                 160 

Ile Leu Trp Ser Ser Leu Leu Leu Asn Glu Asn Cys Leu Val Ile Gly 
                165                 170                 175     

Ala Ser Ile Ser Gly Gln Thr Asp Ile Val Leu Glu Gly Leu Gln Lys 
            180                 185                 190         

Ala Ala Asp Lys Gly Ala Lys Thr Val Leu Met Thr Thr Arg Lys Phe 
        195                 200                 205             

Asp Glu Glu Asp Cys Phe Phe Asp Glu Leu Leu Leu Leu Ala Ser Thr 
    210                 215                 220                 

Asp His Leu Ser Tyr Gly Asn Arg Ile Ser Pro Gln Phe Pro Ile Leu 
225                 230                 235                 240 

Leu Ile Thr Asp Cys Leu Phe Ser Asn Tyr Leu Glu Ser Pro Glu Arg 
                245                 250                 255     

Gln Tyr Tyr Tyr Asn Gln Thr Ile Ile His Lys Glu Glu 
            260                 265                 

<210>   2693
<211>   585
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2693
atgaaaagaa taattccagt ttatatattc caacaagtaa atgtcctatt ggtatctcta   60
tacttattga aatttctttg tatcggtgag ttaactatac tacaggttct ctatggtgcg   120
tctctttttt cttttttatg gatgtatggt caacgaaaac aagtggtcaa ggtcaatatg   180
aaaactagga tgaaatgcct tggtattgga ctagctagtc tactgattat aagtctatgt   240
tttagcctga ttcatgctca aggaagcacg aatcaaacaa atttaattgg ccttcaacat   300
caagttcctt ggttttcatt tttattgttc ttaatcaatg cgagtatggt tgaagaattt   360
ctgtatcgtg aaattttatg gaacttggtt agaaaattag atattcgagt tgctttgaca   420
agtgttttat ttgccttagt acatcatcca ggaaccattc tagcttggtg tctgtacgtt   480
tcacttggaa tgtttttagg tatggtgcgc tataaatctg acttatgggg aagtatgggg   540
ttacatttgg tgtggaactt tttagtttat agtttgctgc ttttt                   585

<210>   2694
<211>   195
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903249 (e-100)

<400>   2694
Met Lys Arg Ile Ile Pro Val Tyr Ile Phe Gln Gln Val Asn Val Leu 
1               5                   10                  15      

Leu Val Ser Leu Tyr Leu Leu Lys Phe Leu Cys Ile Gly Glu Leu Thr 
            20                  25                  30          

Ile Leu Gln Val Leu Tyr Gly Ala Ser Leu Phe Ser Phe Leu Trp Met 
        35                  40                  45              

Tyr Gly Gln Arg Lys Gln Val Val Lys Val Asn Met Lys Thr Arg Met 
    50                  55                  60                  

Lys Cys Leu Gly Ile Gly Leu Ala Ser Leu Leu Ile Ile Ser Leu Cys 
65                  70                  75                  80  

Phe Ser Leu Ile His Ala Gln Gly Ser Thr Asn Gln Thr Asn Leu Ile 
                85                  90                  95      

Gly Leu Gln His Gln Val Pro Trp Phe Ser Phe Leu Leu Phe Leu Ile 
            100                 105                 110         

Asn Ala Ser Met Val Glu Glu Phe Leu Tyr Arg Glu Ile Leu Trp Asn 
        115                 120                 125             

Leu Val Arg Lys Leu Asp Ile Arg Val Ala Leu Thr Ser Val Leu Phe 
    130                 135                 140                 

Ala Leu Val His His Pro Gly Thr Ile Leu Ala Trp Cys Leu Tyr Val 
145                 150                 155                 160 

Ser Leu Gly Met Phe Leu Gly Met Val Arg Tyr Lys Ser Asp Leu Trp 
                165                 170                 175     

Gly Ser Met Gly Leu His Leu Val Trp Asn Phe Leu Val Tyr Ser Leu 
            180                 185                 190         

Leu Leu Phe 
        195 

<210>   2695
<211>   231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2695
atggctgaac gattttggga gaacttgtcc attattttgg ctgaaagaaa tatcagctgg   60
attgagttaa ccagaaaaat gtttgcggga gagtttcact atccaagtga attgaatcgt   120
ttatatcaaa agattcgcca ctacaagatg gaacaacgaa tgcctcaaag tccatgggta   180
gaaaggattg tgcagatatt agatttagat tatgaagatt tatttcggag g            231

<210>   2696
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2696
Met Ala Glu Arg Phe Trp Glu Asn Leu Ser Ile Ile Leu Ala Glu Arg 
1               5                   10                  15      

Asn Ile Ser Trp Ile Glu Leu Thr Arg Lys Met Phe Ala Gly Glu Phe 
            20                  25                  30          

His Tyr Pro Ser Glu Leu Asn Arg Leu Tyr Gln Lys Ile Arg His Tyr 
        35                  40                  45              

Lys Met Glu Gln Arg Met Pro Gln Ser Pro Trp Val Glu Arg Ile Val 
    50                  55                  60                  

Gln Ile Leu Asp Leu Asp Tyr Glu Asp Leu Phe Arg Arg 
65                  70                  75          

<210>   2697
<211>   378
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2697

atgattgatc tctatctaag taaaaatagc caaagaaatc aacttctttt agacttcttc   60
caaaactatg gcattgaggt atcttgtcat tcagtttctg aaatgacaaa ggacaaatta   120
attgagatga tgagctattc ttcagattgt tttgagtttt tatctcccaa tttattacga   180
tttaagaacc gtgacaatct aagattaacg gatttcgttg agataatttt aaaaaatcct   240
gaactaacca tcggacttcc ttttgtggtt tcaaataagc gggtttatcc aagtctgaat   300
ttggaagagg ctagagctct attgccaaga gatacgaaac aattgattta catggcacaa   360
acacattatt tatctaac                                                 378


<210>   2698
<211>   126
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903250 (2.E-66)

<400>   2698
Met Ile Asp Leu Tyr Leu Ser Lys Asn Ser Gln Arg Asn Gln Leu Leu 
1               5                   10                  15      

Leu Asp Phe Phe Gln Asn Tyr Gly Ile Glu Val Ser Cys His Ser Val 
            20                  25                  30          

Ser Glu Met Thr Lys Asp Lys Leu Ile Glu Met Met Ser Tyr Ser Ser 
        35                  40                  45              

Asp Cys Phe Glu Phe Leu Ser Pro Asn Leu Leu Arg Phe Lys Asn Arg 
    50                  55                  60                  

Asp Asn Leu Arg Leu Thr Asp Phe Val Glu Ile Ile Leu Lys Asn Pro 
65                  70                  75                  80  

Glu Leu Thr Ile Gly Leu Pro Phe Val Val Ser Asn Lys Arg Val Tyr 
                85                  90                  95      

Pro Ser Leu Asn Leu Glu Glu Ala Arg Ala Leu Leu Pro Arg Asp Thr 
            100                 105                 110         

Lys Gln Leu Ile Tyr Met Ala Gln Thr His Tyr Leu Ser Asn 
        115                 120                 125     

<210>   2699
<211>   186
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2699
ttgatgccca attatccatg tgagtttgag gtaacatttt tagatgatta ccataaaaaa   60
cataattacc cactatttta tgaatcctat cttcaaaacg ttatggaatt ccttgaaagt   120
caggatataa agaacggagt taatgccttt gtagatgata atcagaatct tgtttttgtt   180
ttatat                                                              186

<210>   2700
<211>   62
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903251 (9.E-26)

<400>   2700
Met Met Pro Asn Tyr Pro Cys Glu Phe Glu Val Thr Phe Leu Asp Asp 
1               5                   10                  15      

Tyr His Lys Lys His Asn Tyr Pro Leu Phe Tyr Glu Ser Tyr Leu Gln 
            20                  25                  30          

Asn Val Met Glu Phe Leu Glu Ser Gln Asp Ile Lys Asn Gly Val Asn 
        35                  40                  45              

Ala Phe Val Asp Asp Asn Gln Asn Leu Val Phe Val Leu Tyr 
    50                  55                  60          

<210>   2701
<211>   1221
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2701
atgatttggg ttttagattt atttgctggg ataggaggct ttaggatggg aatggaagct   60
caagggcatg agtgcttggg attttgtgag attgataaat ttgctaggaa atcttataag   120
tccatttttc aaacggaagg agaaatagaa tttcatgaca tacgagatgt ttcagatgac   180
gaatttaaaa aacttagagg gaaagtcgat gtcatctgtg ggggattccc ttgtcaagca   240
ttttcaatcg caggaagacg attgggattt gaagatacta gaggaacttt gttctttgaa   300
attgctcggg cggccaaaca aatccaacca cgttttcttt ttcttgaaaa tgttaaaggc   360
ctactcaatc acgataaggg acggacgttc accacaatac ttaccacact tgatgagttg   420
gggtttgatg ttgagtggca ggtgcttaac agtaaggatt ttggcgttcc caaaaacaga   480
gagagggtgt ttattatcgg acattctaga aagaaaggta ccagactctt atttcctttc   540
agacgagaag gtcaagcaac taactctgag actttgaaag cactaggaaa tttgaatcca   600
tcaagaagtg gaatgagcgg taaagtctat tattcagaag gtcttgcgcc aaccttagtt   660
cgtggtaaag gagaaggatt taaagttgcg attccttgta tgacaccaga tagattagac   720
aagagacaaa atgggagacg ctttaaggaa aatcaagagc cgatgtttac tttaaatact   780
caggatcgtt atggcattgt cgttgttgga gatttaccga ctagctttaa ggagacaggt   840
cgtgtctatg gaagtgaggg cttatctcca acactgacta cgatgcaagg aggagataaa   900
atccccaaaa tactaattcc agaaccaatc caatttctaa aagtacggga agcaacgaaa   960
aaaggatatg ctcaagcaga gattggggat tcaatcaatt tagaaagacc aagttctcag   1020
tatcgtcgtg gtagagttgg aaaaggtata gctaatacgt taacaactag tggtcaaatg   1080
ggagtagtag tggctagcta tgaaggagaa gataaacaag tttaccaagt agctggtgtt   1140
ttaatagatg gacaatttta ccgtttgaga atacgacgaa tcactcctaa agagtgtttt   1200
cgattgcatg gctttcctga t                                             1221

<210>   2702
<211>   407
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type II DNA modification methyltransferase Spn5252IP (spn5252IMP)
<223>   Cellular location: cytoplasm

<400>   2702
Met Ile Trp Val Leu Asp Leu Phe Ala Gly Ile Gly Gly Phe Arg Met 

1               5                   10                  15      

Gly Met Glu Ala Gln Gly His Glu Cys Leu Gly Phe Cys Glu Ile Asp 
            20                  25                  30          

Lys Phe Ala Arg Lys Ser Tyr Lys Ser Ile Phe Gln Thr Glu Gly Glu 
        35                  40                  45              

Ile Glu Phe His Asp Ile Arg Asp Val Ser Asp Asp Glu Phe Lys Lys 
    50                  55                  60                  

Leu Arg Gly Lys Val Asp Val Ile Cys Gly Gly Phe Pro Cys Gln Ala 
65                  70                  75                  80  

Phe Ser Ile Ala Gly Arg Arg Leu Gly Phe Glu Asp Thr Arg Gly Thr 
                85                  90                  95      

Leu Phe Phe Glu Ile Ala Arg Ala Ala Lys Gln Ile Gln Pro Arg Phe 
            100                 105                 110         

Leu Phe Leu Glu Asn Val Lys Gly Leu Leu Asn His Asp Lys Gly Arg 
        115                 120                 125             

Thr Phe Thr Thr Ile Leu Thr Thr Leu Asp Glu Leu Gly Phe Asp Val 
    130                 135                 140                 

Glu Trp Gln Val Leu Asn Ser Lys Asp Phe Gly Val Pro Lys Asn Arg 
145                 150                 155                 160 

Glu Arg Val Phe Ile Ile Gly His Ser Arg Lys Lys Gly Thr Arg Leu 
                165                 170                 175     

Leu Phe Pro Phe Arg Arg Glu Gly Gln Ala Thr Asn Ser Glu Thr Leu 
            180                 185                 190         

Lys Ala Leu Gly Asn Leu Asn Pro Ser Arg Ser Gly Met Ser Gly Lys 
        195                 200                 205             

Val Tyr Tyr Ser Glu Gly Leu Ala Pro Thr Leu Val Arg Gly Lys Gly 
    210                 215                 220                 

Glu Gly Phe Lys Val Ala Ile Pro Cys Met Thr Pro Asp Arg Leu Asp 
225                 230                 235                 240 

Lys Arg Gln Asn Gly Arg Arg Phe Lys Glu Asn Gln Glu Pro Met Phe 
                245                 250                 255     

Thr Leu Asn Thr Gln Asp Arg Tyr Gly Ile Val Val Val Gly Asp Leu 
            260                 265                 270         

Pro Thr Ser Phe Lys Glu Thr Gly Arg Val Tyr Gly Ser Glu Gly Leu 
        275                 280                 285             

Ser Pro Thr Leu Thr Thr Met Gln Gly Gly Asp Lys Ile Pro Lys Ile 
    290                 295                 300                 

Leu Ile Pro Glu Pro Ile Gln Phe Leu Lys Val Arg Glu Ala Thr Lys 
305                 310                 315                 320 

Lys Gly Tyr Ala Gln Ala Glu Ile Gly Asp Ser Ile Asn Leu Glu Arg 
                325                 330                 335     

Pro Ser Ser Gln Tyr Arg Arg Gly Arg Val Gly Lys Gly Ile Ala Asn 
            340                 345                 350         

Thr Leu Thr Thr Ser Gly Gln Met Gly Val Val Val Ala Ser Tyr Glu 
        355                 360                 365             

Gly Glu Asp Lys Gln Val Tyr Gln Val Ala Gly Val Leu Ile Asp Gly 
    370                 375                 380                 

Gln Phe Tyr Arg Leu Arg Ile Arg Arg Ile Thr Pro Lys Glu Cys Phe 
385                 390                 395                 400 

Arg Leu His Gly Phe Pro Asp 
                405         

<210>   2703
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2703
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattatt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg taggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   2704
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903941 (2.E-46)

<400>   2704
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   2705
<211>   177
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2705
gtgagtggga taaaagtttc atttagttta ttcagtacaa atttaacggg tcaagattta   60
tatactagtg gtgtttttgg ggctgagaga agtatcttga ttttatgtgt ggtttttata   120
cttacagttg ttctgctcca aagagcttgt agagaagaat tagctcataa aggagat      177

<210>   2706
<211>   59
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   2706
Met Ser Gly Ile Lys Val Ser Phe Ser Leu Phe Ser Thr Asn Leu Thr 
1               5                   10                  15      

Gly Gln Asp Leu Tyr Thr Ser Gly Val Phe Gly Ala Glu Arg Ser Ile 
            20                  25                  30          

Leu Ile Leu Cys Val Val Phe Ile Leu Thr Val Val Leu Leu Gln Arg 
        35                  40                  45              

Ala Cys Arg Glu Glu Leu Ala His Lys Gly Asp 
    50                  55                  

<210>   2707
<211>   135
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2707
atggcagcag aagtattaaa tcttcaatta gtatctgttc aagttgacga aacagatgaa   60
gttgatggaa tgcgatttag tacattcagt acaaaccgtt gcggtaactg gagtgctttt   120
agttgggaaa attgt                                                    135

<210>   2708
<211>   45
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2708
Met Ala Ala Glu Val Leu Asn Leu Gln Leu Val Ser Val Gln Val Asp 
1               5                   10                  15      

Glu Thr Asp Glu Val Asp Gly Met Arg Phe Ser Thr Phe Ser Thr Asn 
            20                  25                  30          

Arg Cys Gly Asn Trp Ser Ala Phe Ser Trp Glu Asn Cys 
        35                  40                  45  

<210>   2709
<211>   1317
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2709
atgctcagat tagtttacta tcaattttta cataataaga aacaatggtt aggcgtttca   60
ccagtaattt ttgtttcgag tttagttatg ggattggctg ttaatggggt aattaatgtt   120
gagaataatt cgcaagtatt tgtcggactt ccagatccta aaccaatttt tatgtttccg   180
atagtattcg gaggagtaac attattcttt gtgctctcta acataataaa tatgttggtt   240
gaaattttta gagatgatta cgaacttctg gaggtgttgg gagcaagtcg ccttcaacta   300
tcatttcttg tggggggaca gatttttatc atttcctcga ttattagttt tattgcatat   360
ctatgctcta tatttgttac gtcaaattat tattattttt tacaatactt tttcggggaa   420
aatatattac ctgatatcca atttcaaacg agtgctgttg gatgtatcat tacagtagtg   480
ttgatttcat ttttagcctt tctaagtggt tgcttttata cgttcaagaa gattagaaat   540
aggaagagtt ctaaaataag gcatgttctt tcaatagtaa aaagaatact gctattggct   600
ggttttagtg ttatctggtt gctttctttg caacaaattt tccaagatag cacaatttta   660
gcgaaggccc agataatatt caatattgta atcttagata ttgtgattat ttatcaatta   720
tctcctttta tacagtcatg ttttatcaaa ctactttcta taattatatt tagaaataat   780
tttatgttca ttgtttcgaa gtggaattta ctatattgta agtcttatat aaaatctatc   840
agtgctgcaa ttacaggagc tatattacta atttctagtt ttcaaatgat ttctcagaat   900
atactatctc aatttcaaga tgacagtgat ttagagctaa aagtagcatt tattgtctat   960
gtaggagcac caattttgat agtacttgca aatattattt caattgcatt tttgtcatcg   1020
catcaagaaa ggattgagat tcagcaattt gaaattttag gaacttctaa ttaccagatg   1080
gttaagatta aagttggtga ggctatattt ttgacatttg ttacttcatt aattgcattt   1140
ttacttaaca ttaaaattat ggctttaata tactactctt tagaggatat tttaatagat   1200
gatatgaatc ttttggggtt aatacttcca aattttatag tatctattat tttatttatt   1260
ttaatattta ttactaaaag ttcctatttt atctttaaga atgcaaaaat tatttct      1317

<210>   2710
<211>   439
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903244 (0.E+01)

<400>   2710
Met Leu Arg Leu Val Tyr Tyr Gln Phe Leu His Asn Lys Lys Gln Trp 
1               5                   10                  15      

Leu Gly Val Ser Pro Val Ile Phe Val Ser Ser Leu Val Met Gly Leu 
            20                  25                  30          

Ala Val Asn Gly Val Ile Asn Val Glu Asn Asn Ser Gln Val Phe Val 
        35                  40                  45              

Gly Leu Pro Asp Pro Lys Pro Ile Phe Met Phe Pro Ile Val Phe Gly 
    50                  55                  60                  

Gly Val Thr Leu Phe Phe Val Leu Ser Asn Ile Ile Asn Met Leu Val 
65                  70                  75                  80  

Glu Ile Phe Arg Asp Asp Tyr Glu Leu Leu Glu Val Leu Gly Ala Ser 
                85                  90                  95      

Arg Leu Gln Leu Ser Phe Leu Val Gly Gly Gln Ile Phe Ile Ile Ser 
            100                 105                 110         

Ser Ile Ile Ser Phe Ile Ala Tyr Leu Cys Ser Ile Phe Val Thr Ser 
        115                 120                 125             

Asn Tyr Tyr Tyr Phe Leu Gln Tyr Phe Phe Gly Glu Asn Ile Leu Pro 
    130                 135                 140                 

Asp Ile Gln Phe Gln Thr Ser Ala Val Gly Cys Ile Ile Thr Val Val 
145                 150                 155                 160 

Leu Ile Ser Phe Leu Ala Phe Leu Ser Gly Cys Phe Tyr Thr Phe Lys 
                165                 170                 175     

Lys Ile Arg Asn Arg Lys Ser Ser Lys Ile Arg His Val Leu Ser Ile 
            180                 185                 190         

Val Lys Arg Ile Leu Leu Leu Ala Gly Phe Ser Val Ile Trp Leu Leu 
        195                 200                 205             


Ser Leu Gln Gln Ile Phe Gln Asp Ser Thr Ile Leu Ala Lys Ala Gln 
    210                 215                 220                 

Ile Ile Phe Asn Ile Val Ile Leu Asp Ile Val Ile Ile Tyr Gln Leu 
225                 230                 235                 240 

Ser Pro Phe Ile Gln Ser Cys Phe Ile Lys Leu Leu Ser Ile Ile Ile 
                245                 250                 255     

Phe Arg Asn Asn Phe Met Phe Ile Val Ser Lys Trp Asn Leu Leu Tyr 
            260                 265                 270         

Cys Lys Ser Tyr Ile Lys Ser Ile Ser Ala Ala Ile Thr Gly Ala Ile 
        275                 280                 285             

Leu Leu Ile Ser Ser Phe Gln Met Ile Ser Gln Asn Ile Leu Ser Gln 
    290                 295                 300                 

Phe Gln Asp Asp Ser Asp Leu Glu Leu Lys Val Ala Phe Ile Val Tyr 
305                 310                 315                 320 

Val Gly Ala Pro Ile Leu Ile Val Leu Ala Asn Ile Ile Ser Ile Ala 
                325                 330                 335     

Phe Leu Ser Ser His Gln Glu Arg Ile Glu Ile Gln Gln Phe Glu Ile 
            340                 345                 350         

Leu Gly Thr Ser Asn Tyr Gln Met Val Lys Ile Lys Val Gly Glu Ala 
        355                 360                 365             

Ile Phe Leu Thr Phe Val Thr Ser Leu Ile Ala Phe Leu Leu Asn Ile 
    370                 375                 380                 

Lys Ile Met Ala Leu Ile Tyr Tyr Ser Leu Glu Asp Ile Leu Ile Asp 
385                 390                 395                 400 

Asp Met Asn Leu Leu Gly Leu Ile Leu Pro Asn Phe Ile Val Ser Ile 
                405                 410                 415     

Ile Leu Phe Ile Leu Ile Phe Ile Thr Lys Ser Ser Tyr Phe Ile Phe 
            420                 425                 430         

Lys Asn Ala Lys Ile Ile Ser 
        435                 

<210>   2711
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2711
gtgattggag gcaagaatat ggataaagat tatatattaa aagtgaaagg gctgtatcat   60
caatttttac taggaaataa taaaacgttg caagtgctga aaaatgtttc tctttctgct   120
tcgagaggag aatttataag tattctagga attagtggtt ctggaaagtc aactttatta   180
aaatgtattt ctagtttgct tgaaccaaca agtggggaag taattttaaa tggaatcaac   240
ccctataaaa tcagaaatgc aaaattgtca agtataagac gtaacgaagt atcttttata   300
tttcaagcat acaatttaat accttccctg ccggtaatag aaaatatagc acttcctttg   360
cgattatcac aaaaaaaatt aactattaaa aatgtagaaa acttactcaa aagaatgaag   420
tttaatgctg gcttaaacga ttttgttgga actctgtctg gtggagaaca acagaaggtt   480
gctatagcta gagcggttat tgctgatagt gatataatat ttgctgatga gccaactggg   540
gctttagaca gcgtttctcg tgaagtaatt tttgaattat tgagagagtt agtaggggcg   600
ggtaagtgtg taattatggt aacgcacgat atagaattgg cctcgaaaac tgatcgtgca   660
ttaatattga aagatggaaa aattttcaaa gaacttcata gacctagcgg ggaagagttg   720
tataaaatct tagaggtaca atcaactacg gaggaa                             756

<210>   2712
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903245 (e-134)

<400>   2712
Met Ile Gly Gly Lys Asn Met Asp Lys Asp Tyr Ile Leu Lys Val Lys 
1               5                   10                  15      

Gly Leu Tyr His Gln Phe Leu Leu Gly Asn Asn Lys Thr Leu Gln Val 
            20                  25                  30          

Leu Lys Asn Val Ser Leu Ser Ala Ser Arg Gly Glu Phe Ile Ser Ile 
        35                  40                  45              

Leu Gly Ile Ser Gly Ser Gly Lys Ser Thr Leu Leu Lys Cys Ile Ser 
    50                  55                  60                  

Ser Leu Leu Glu Pro Thr Ser Gly Glu Val Ile Leu Asn Gly Ile Asn 
65                  70                  75                  80  

Pro Tyr Lys Ile Arg Asn Ala Lys Leu Ser Ser Ile Arg Arg Asn Glu 
                85                  90                  95      

Val Ser Phe Ile Phe Gln Ala Tyr Asn Leu Ile Pro Ser Leu Pro Val 
            100                 105                 110         

Ile Glu Asn Ile Ala Leu Pro Leu Arg Leu Ser Gln Lys Lys Leu Thr 
        115                 120                 125             

Ile Lys Asn Val Glu Asn Leu Leu Lys Arg Met Lys Phe Asn Ala Gly 
    130                 135                 140                 

Leu Asn Asp Phe Val Gly Thr Leu Ser Gly Gly Glu Gln Gln Lys Val 
145                 150                 155                 160 

Ala Ile Ala Arg Ala Val Ile Ala Asp Ser Asp Ile Ile Phe Ala Asp 
                165                 170                 175     

Glu Pro Thr Gly Ala Leu Asp Ser Val Ser Arg Glu Val Ile Phe Glu 
            180                 185                 190         

Leu Leu Arg Glu Leu Val Gly Ala Gly Lys Cys Val Ile Met Val Thr 
        195                 200                 205             

His Asp Ile Glu Leu Ala Ser Lys Thr Asp Arg Ala Leu Ile Leu Lys 
    210                 215                 220                 

Asp Gly Lys Ile Phe Lys Glu Leu His Arg Pro Ser Gly Glu Glu Leu 
225                 230                 235                 240 

Tyr Lys Ile Leu Glu Val Gln Ser Thr Thr Glu Glu 
                245                 250         

<210>   2713
<211>   1605
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2713
atgaattatt taaaatttat aaaaaagact aaacttatat taatggggat tttaatattt   60
ctatcttcgt ttaatggtgt cttgctctca ggaattattg tatatgcagg tagtttaaat   120
cagacttcct cattttctga cgttctaaga tttggtgcta taagtattct gggttggtca   180
gcaatctata tatcaaatta ctatttagaa gtaacggaag catcaataac taaagatata   240
aatgtaaaaa ttaaacaagg atattttaga gaacagtatc tttcttctga aatggttaaa   300
gattactcat ctattatttc agttttgtca aatgatttga gattaatcga agaaaactat   360
tttagacaaa tttttgaaat aatttcttca atattgttgt tcatcgtctc tctaagtttt   420
atgctttatt taaacttcct agtttcaata atatttattg tattatcagc attgccgatt   480
atagtacctg tctttatgaa gaagatgttg tctaattcag ctaatgagta ctctaacagc   540
aatgcagagt atactcacat aataaaagaa atttttaatg gttttaagac attaaaatct   600
tattctgtta ctaaagaaat aattagtttg tcggataaaa agttggataa actagaagat   660
tctactttta atttgaaacg atcagaggtt ctttcaaaat tggttgcagt actaatttca   720
ggtttttgct ttctagttcc cttggttgta ggatgttatt ttgtaattta tcataaaagc   780
ctttctttta gtgaactgat aggtattttc ttagcaaacg ataaagtttt agggccgata   840
caatcaattg cctattcatt aaataagata aatacaacca aagatttaag gaaaccgttt   900
ttaaaatact taagtggaga gaagaatttt atagacgctg aacatgataa taacggactg   960
tatacttcat caatagatga gatacacatg aaagatgttg tatattctat tacaccagaa   1020
aataaattaa gtattgactt ctcatttaag tcaccattta gggtattatt aacaggaact   1080
tctggtagtg ggaaaacaac gattttaaat ttaattaatg gttctttaaa gccacaaaaa   1140
ggttatgtaa atttgttatc acatgggaaa aagagttcag attcaatacc aacagttgat   1200
cagacaccat atatttttga cactactatt cgtgagaacg taactttatt tcaaaatgaa   1260
tatttttcag atgatcagat aattgaggtg ttaaaaaagg taaatctata tgaagaatta   1320
gaaaagatag atatactaaa ttatcaatgt ggtgaaaatg gtagtaattt gtctggaggt   1380
caaaaacaaa aaatagcttt agctagagct ctgattagaa ataataaagt gtacttattt   1440
gacgaaatat cagctaattt agataatgat aattcaaatt ccatacatga tattctgttc   1500
aatttaggta tttcatttat tgaagtttca catcattatg acttaaatga caagagatac   1560
actgatatat ataaattgga aaatggaaca cttttcaaaa ttaag                   1605

<210>   2714
<211>   535
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   toxin secretion ABC transporter, ATP-binding/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903246 (0.E+01)

<400>   2714
Met Asn Tyr Leu Lys Phe Ile Lys Lys Thr Lys Leu Ile Leu Met Gly 
1               5                   10                  15      

Ile Leu Ile Phe Leu Ser Ser Phe Asn Gly Val Leu Leu Ser Gly Ile 
            20                  25                  30          

Ile Val Tyr Ala Gly Ser Leu Asn Gln Thr Ser Ser Phe Ser Asp Val 
        35                  40                  45              

Leu Arg Phe Gly Ala Ile Ser Ile Leu Gly Trp Ser Ala Ile Tyr Ile 
    50                  55                  60                  

Ser Asn Tyr Tyr Leu Glu Val Thr Glu Ala Ser Ile Thr Lys Asp Ile 
65                  70                  75                  80  

Asn Val Lys Ile Lys Gln Gly Tyr Phe Arg Glu Gln Tyr Leu Ser Ser 
                85                  90                  95      

Glu Met Val Lys Asp Tyr Ser Ser Ile Ile Ser Val Leu Ser Asn Asp 
            100                 105                 110         

Leu Arg Leu Ile Glu Glu Asn Tyr Phe Arg Gln Ile Phe Glu Ile Ile 
        115                 120                 125             

Ser Ser Ile Leu Leu Phe Ile Val Ser Leu Ser Phe Met Leu Tyr Leu 
    130                 135                 140                 

Asn Phe Leu Val Ser Ile Ile Phe Ile Val Leu Ser Ala Leu Pro Ile 
145                 150                 155                 160 

Ile Val Pro Val Phe Met Lys Lys Met Leu Ser Asn Ser Ala Asn Glu 
                165                 170                 175     

Tyr Ser Asn Ser Asn Ala Glu Tyr Thr His Ile Ile Lys Glu Ile Phe 
            180                 185                 190         

Asn Gly Phe Lys Thr Leu Lys Ser Tyr Ser Val Thr Lys Glu Ile Ile 
        195                 200                 205             

Ser Leu Ser Asp Lys Lys Leu Asp Lys Leu Glu Asp Ser Thr Phe Asn 
    210                 215                 220                 

Leu Lys Arg Ser Glu Val Leu Ser Lys Leu Val Ala Val Leu Ile Ser 
225                 230                 235                 240 

Gly Phe Cys Phe Leu Val Pro Leu Val Val Gly Cys Tyr Phe Val Ile 
                245                 250                 255     

Tyr His Lys Ser Leu Ser Phe Ser Glu Leu Ile Gly Ile Phe Leu Ala 
            260                 265                 270         

Asn Asp Lys Val Leu Gly Pro Ile Gln Ser Ile Ala Tyr Ser Leu Asn 
        275                 280                 285             

Lys Ile Asn Thr Thr Lys Asp Leu Arg Lys Pro Phe Leu Lys Tyr Leu 
    290                 295                 300                 

Ser Gly Glu Lys Asn Phe Ile Asp Ala Glu His Asp Asn Asn Gly Leu 
305                 310                 315                 320 

Tyr Thr Ser Ser Ile Asp Glu Ile His Met Lys Asp Val Val Tyr Ser 
                325                 330                 335     

Ile Thr Pro Glu Asn Lys Leu Ser Ile Asp Phe Ser Phe Lys Ser Pro 
            340                 345                 350         

Phe Arg Val Leu Leu Thr Gly Thr Ser Gly Ser Gly Lys Thr Thr Ile 
        355                 360                 365             

Leu Asn Leu Ile Asn Gly Ser Leu Lys Pro Gln Lys Gly Tyr Val Asn 
    370                 375                 380                 

Leu Leu Ser His Gly Lys Lys Ser Ser Asp Ser Ile Pro Thr Val Asp 
385                 390                 395                 400 

Gln Thr Pro Tyr Ile Phe Asp Thr Thr Ile Arg Glu Asn Val Thr Leu 
                405                 410                 415     

Phe Gln Asn Glu Tyr Phe Ser Asp Asp Gln Ile Ile Glu Val Leu Lys 
            420                 425                 430         

Lys Val Asn Leu Tyr Glu Glu Leu Glu Lys Ile Asp Ile Leu Asn Tyr 
        435                 440                 445             

Gln Cys Gly Glu Asn Gly Ser Asn Leu Ser Gly Gly Gln Lys Gln Lys 
    450                 455                 460                 

Ile Ala Leu Ala Arg Ala Leu Ile Arg Asn Asn Lys Val Tyr Leu Phe 
465                 470                 475                 480 

Asp Glu Ile Ser Ala Asn Leu Asp Asn Asp Asn Ser Asn Ser Ile His 
                485                 490                 495     

Asp Ile Leu Phe Asn Leu Gly Ile Ser Phe Ile Glu Val Ser His His 
            500                 505                 510         

Tyr Asp Leu Asn Asp Lys Arg Tyr Thr Asp Ile Tyr Lys Leu Glu Asn 
        515                 520                 525             

Gly Thr Leu Phe Lys Ile Lys 
    530                 535 

<210>   2715
<211>   1938
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2715
gtgaatcaga gtaatgaaat atttttaaat acaatacagg aaaaaacaca ctataagagg   60
tctatctctt catcatttca ggaattaaaa aaatggaatt ctttgatatt taggagaggg   120
cgatattggt accaatttga taattggagt atacccaata ctggtgtaat aaaggaatgg   180
tatgtcgaag ataatgactg gattcctaag gttagttctt ccagtttaga caattcaaat   240
tcacttaaaa ttgtctttga tgtggaaaaa tatactttgc cagatgatag tatcttacag   300
gatgttagga tttcatctga tgagagttat atagttttgg ttgtatcctc actgcgtacg   360
actaatttaa ttggaataaa aaaatatact atggaagagt tatttatcat tgaagatatt   420
tcagtagaaa gttcgttcta tttgggtaaa ttcggtgtta tgtatactcg ctccaaagag   480
tacgggaggc caagtaagtt attctataaa tcttttgata gctttacaga agaggaactg   540
tttgaagaaa acgaatgctc ttttcgatta aaaatagtcc acattgatag caataattgt   600
tttgtaaagt cagtagactt tcagaaaggc aggatttttc tatacagttt cgaccggacg   660
ggttttgtta gacactctta cacagaaacg gtagccccaa cacctagaga tatcgctcta   720
tttagtacag aaaaagcaca gtactttctt gggctctctt caactgaaga aaagaaagat   780
caactaattc taagggaaac ttcttcggga gacagagttt ctattactat accatatcaa   840
gatagggcta gaagagttca ctgtatagga cgttatatcc ttttagactg ttcaaacgca   900
gcgaattccg tcttttatct tgctacattt aaaaataata gtttgaggga gttgagtgtt   960
aataagataa catttgatga aaagacaaca ctttatgaaa attcattttc tgatcgtgtt   1020
cttctgtttt tagagaggag aactttttac gaaaaaatac ttagttttga tttaatagaa   1080
aatacattaa aaactgaatt tgaaagaccc atcataaaat cgaataatac taaatatttt   1140
tctaaggtga tttggactaa aaaagacagt tatgatgtaa gcataccgat ttctttattt   1200
tggaaaagtg aagatacgga tgagctccca agaagaaaaa aatgtattct aagtgtctat   1260
ggggcttatg gtaagaatga taattctgat ttagatgaaa ttatgttatc tataatagat   1320
gcaggtttta tttatgctat agttcatgta agaggtggag gctatttggg tggtgaatgg   1380
tatcgctcag gaaaggcgtt aaacaaatgg aattctatca gagattttat tgagggagta   1440
aattatttaa gggaaaatga tgtaattgac agtaagcgat taggtttaat aacttctagt   1500
gcaggtggaa taattgctgg tgcggtgttg aacgaggaaa aaaatttatt gcaaagcatt   1560
ctcttatttt cgccatttat aaatccttat gatacacttc agaatccaaa tgatcctctt   1620
tctaagaccg aaatagcaga gtggggagat attagagacc ctgaagtaaa ggcttatata   1680
aagtcatatt cgcctatgca aaatattgaa aaggcacgag actcaaatac tgttatagtt   1740
aatattttgg gtgagaaaga cccatatatt aataataacg aagtgataga gtggtcaaag   1800
aaattaaatt ctattggagt taaaagtttg ttgtatttaa acaaagcagc tggtcatgga   1860
ggttttactc catcagatgt tctcttaatg attgatactt taaattattt ctttgaagaa   1920
gtgggaagga ataactta                                                 1938

<210>   2716
<211>   646
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   prolyl oligopeptidase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903247 (0.E+01)

<400>   2716
Met Asn Gln Ser Asn Glu Ile Phe Leu Asn Thr Ile Gln Glu Lys Thr 
1               5                   10                  15      

His Tyr Lys Arg Ser Ile Ser Ser Ser Phe Gln Glu Leu Lys Lys Trp 
            20                  25                  30          

Asn Ser Leu Ile Phe Arg Arg Gly Arg Tyr Trp Tyr Gln Phe Asp Asn 
        35                  40                  45              

Trp Ser Ile Pro Asn Thr Gly Val Ile Lys Glu Trp Tyr Val Glu Asp 
    50                  55                  60                  

Asn Asp Trp Ile Pro Lys Val Ser Ser Ser Ser Leu Asp Asn Ser Asn 
65                  70                  75                  80  

Ser Leu Lys Ile Val Phe Asp Val Glu Lys Tyr Thr Leu Pro Asp Asp 
                85                  90                  95      

Ser Ile Leu Gln Asp Val Arg Ile Ser Ser Asp Glu Ser Tyr Ile Val 
            100                 105                 110         

Leu Val Val Ser Ser Leu Arg Thr Thr Asn Leu Ile Gly Ile Lys Lys 
        115                 120                 125             

Tyr Thr Met Glu Glu Leu Phe Ile Ile Glu Asp Ile Ser Val Glu Ser 
    130                 135                 140                 

Ser Phe Tyr Leu Gly Lys Phe Gly Val Met Tyr Thr Arg Ser Lys Glu 
145                 150                 155                 160 

Tyr Gly Arg Pro Ser Lys Leu Phe Tyr Lys Ser Phe Asp Ser Phe Thr 
                165                 170                 175     

Glu Glu Glu Leu Phe Glu Glu Asn Glu Cys Ser Phe Arg Leu Lys Ile 
            180                 185                 190         

Val His Ile Asp Ser Asn Asn Cys Phe Val Lys Ser Val Asp Phe Gln 
        195                 200                 205             

Lys Gly Arg Ile Phe Leu Tyr Ser Phe Asp Arg Thr Gly Phe Val Arg 
    210                 215                 220                 

His Ser Tyr Thr Glu Thr Val Ala Pro Thr Pro Arg Asp Ile Ala Leu 
225                 230                 235                 240 

Phe Ser Thr Glu Lys Ala Gln Tyr Phe Leu Gly Leu Ser Ser Thr Glu 
                245                 250                 255     

Glu Lys Lys Asp Gln Leu Ile Leu Arg Glu Thr Ser Ser Gly Asp Arg 
            260                 265                 270         

Val Ser Ile Thr Ile Pro Tyr Gln Asp Arg Ala Arg Arg Val His Cys 
        275                 280                 285             

Ile Gly Arg Tyr Ile Leu Leu Asp Cys Ser Asn Ala Ala Asn Ser Val 
    290                 295                 300                 

Phe Tyr Leu Ala Thr Phe Lys Asn Asn Ser Leu Arg Glu Leu Ser Val 
305                 310                 315                 320 

Asn Lys Ile Thr Phe Asp Glu Lys Thr Thr Leu Tyr Glu Asn Ser Phe 
                325                 330                 335     

Ser Asp Arg Val Leu Leu Phe Leu Glu Arg Arg Thr Phe Tyr Glu Lys 
            340                 345                 350         

Ile Leu Ser Phe Asp Leu Ile Glu Asn Thr Leu Lys Thr Glu Phe Glu 
        355                 360                 365             

Arg Pro Ile Ile Lys Ser Asn Asn Thr Lys Tyr Phe Ser Lys Val Ile 
    370                 375                 380                 

Trp Thr Lys Lys Asp Ser Tyr Asp Val Ser Ile Pro Ile Ser Leu Phe 
385                 390                 395                 400 

Trp Lys Ser Glu Asp Thr Asp Glu Leu Pro Arg Arg Lys Lys Cys Ile 
                405                 410                 415     

Leu Ser Val Tyr Gly Ala Tyr Gly Lys Asn Asp Asn Ser Asp Leu Asp 

            420                 425                 430         

Glu Ile Met Leu Ser Ile Ile Asp Ala Gly Phe Ile Tyr Ala Ile Val 
        435                 440                 445             

His Val Arg Gly Gly Gly Tyr Leu Gly Gly Glu Trp Tyr Arg Ser Gly 
    450                 455                 460                 

Lys Ala Leu Asn Lys Trp Asn Ser Ile Arg Asp Phe Ile Glu Gly Val 
465                 470                 475                 480 

Asn Tyr Leu Arg Glu Asn Asp Val Ile Asp Ser Lys Arg Leu Gly Leu 
                485                 490                 495     

Ile Thr Ser Ser Ala Gly Gly Ile Ile Ala Gly Ala Val Leu Asn Glu 
            500                 505                 510         

Glu Lys Asn Leu Leu Gln Ser Ile Leu Leu Phe Ser Pro Phe Ile Asn 
        515                 520                 525             

Pro Tyr Asp Thr Leu Gln Asn Pro Asn Asp Pro Leu Ser Lys Thr Glu 
    530                 535                 540                 

Ile Ala Glu Trp Gly Asp Ile Arg Asp Pro Glu Val Lys Ala Tyr Ile 
545                 550                 555                 560 

Lys Ser Tyr Ser Pro Met Gln Asn Ile Glu Lys Ala Arg Asp Ser Asn 
                565                 570                 575     

Thr Val Ile Val Asn Ile Leu Gly Glu Lys Asp Pro Tyr Ile Asn Asn 
            580                 585                 590         

Asn Glu Val Ile Glu Trp Ser Lys Lys Leu Asn Ser Ile Gly Val Lys 
        595                 600                 605             

Ser Leu Leu Tyr Leu Asn Lys Ala Ala Gly His Gly Gly Phe Thr Pro 
    610                 615                 620                 

Ser Asp Val Leu Leu Met Ile Asp Thr Leu Asn Tyr Phe Phe Glu Glu 
625                 630                 635                 640 

Val Gly Arg Asn Asn Leu 
                645     

<210>   2717
<211>   2607
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2717
atggattata atttcaattt ggagcatcct ttctttttca ctaataatga ttatagtaca   60
gatactagca taaagtacca agtaagtctg ccttttaatt ggcacgaagt aatgaataat   120
gatgagtggg tttatcaata ccctattgga aaatttgttg aaagacaagg gtggaaaata   180
cacattagtt cagagtataa cagttcacat gaattgttac aagatgtagc aaaaatttgc   240
catgaaatgc gaattccatt taaacatctt agtacagaag acaaatttat catgcgaaac   300
gggaaattgg ttagtcgagg attttctggt aaatttatta catgttatcc aaatcaaaat   360
gaattagagt cggttttgca aaggttagaa agtgccttaa agcaatataa tgggccatat   420
attttaagcg ataaacgttg ggatgaagca ccaatatatc tgaggtatgg tgtgtttagg   480
ccgtcaaggg atgatgaaaa gaaggttgct attgatgaat taattgttgg cgatgaagtt   540
gttaaagatg aacgtttacc agtatttaaa attccaaaag gtatagtgcc ccctgacttt   600
ttgaataaat ggcttgacaa gaaagataaa aaacagggag actttccctt tattatagat   660
aatgcaatta gattttcaaa cagtggtggg atatataatg ctaggctaaa agaagatggg   720
aaaaaaataa ttttaaaaga ggctagaccg tatacaggtc taggatttga tggtacttat   780
tcttcagaga aattagcttc ggagtgcaaa gcactaaaaa ttctaaatga atggagtgag   840
acgcctaaaa tatactggca cggtaagatc tgggagcaca ccttcttagg aattgaacat   900
atgaagggcg ttccactaaa tagatgggtt accaataatt ttcctttata tgaagttgtt   960
gataagacca aagattatct attgagagtt tcaaagatag tagaaaaact catcgattta   1020
acgaataagt ttcattctga aaatgtatat catcaagatt tacatttagg aaatatcttg   1080
gttaaggatg aagatgagat tagtataata gactgggaac aggctgtctt ttcaaatgat   1140
gaaaaagttg tacataaagt tgcagcccct ggttttagag catggcgaga aacacttccc   1200
agtgagatag attggtatgg tattagacaa atagctcatt atttatacat gccactagta   1260
actacatcgg atttgacata caactatgta agtcaaacca ggatagaagg aaaaaaacta   1320
tttgagtctt tgggttatac aagagaacat atagattatg tagaaagttt attgtcatat   1380
ctagattcta aatgtccaca gattgagaat atttccagga aaaaagtttt aaaacccatg   1440
catgagatta gaactatcga gagtgagcaa gatatacaag attttattat aaaattattg   1500
agagggttta cgctaactta tggacagtgg cgtaaagaat ttcaatcaag attcttccca   1560
gttcattatt atggtctgaa ttttaatcaa ggaattgcgt tttcagattt agctatcctt   1620
tggagttatc aacaactagc taagaaagta aaaaatttca agtttgatga ctattatgag   1680
attcgaacac aggttattaa tgaggcagta aataatttta agaaatcgtc cctttctggt   1740
ctttttgatg gtaaaattgg tacaatctgg ctcatttatg aatttgggga gatagatcgg   1800
gcagttgaac tttttacaac tcattttata gagatatttg agaattcaca aaataaaaat   1860
ttatatagtg ggcaggctgg aattttactg gttggactgt attttcttag taaaggggga   1920
attgataata aactaggaga agaaatacta attaggctta gagaatatac tttaaattat   1980
atagaaaatc cagaaacttt ttgtaaagtt ggcgctagtg atgttcagag taacgatcct   2040
tatgagaatt ttggtggatt actatatggt cacgcagggg tagcttggct cttcggtgaa   2100
gcttataaat taactggtga aagtatctat aaaaatggtc tagaattggc tgtagataaa   2160
gaattagttg cttataaagt agatagtaat aattcattgc agtacagcca aggtcataga   2220
ttactaccat atctagcaac tggaagtgct ggcctgcttt tacttattaa tagaaataaa   2280
gaaatcttgt caagcaaata cttaaaatat ttaacttctt tagagagggc aactgatgta   2340
gttttttgtg tattaccagg tttatttaac ggattttgtg gtcttgaagt tgctaataat   2400
atatatagtg atatcgatga taacttttca ggacaaaaga aattaattga acaactttat   2460
agatatttgt gtgtaattga agaaggattt gttattgcgg gagataatgg tttaaagata   2520
acaacagata ttgcttcggg atttgcgggt gttgcaattg gattggtatc aataatggat   2580

aataaattga cgattcttcc tcaaata                                       2607

<210>   2718
<211>   869
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903248 (0.E+01)

<400>   2718
Met Asp Tyr Asn Phe Asn Leu Glu His Pro Phe Phe Phe Thr Asn Asn 
1               5                   10                  15      

Asp Tyr Ser Thr Asp Thr Ser Ile Lys Tyr Gln Val Ser Leu Pro Phe 
            20                  25                  30          

Asn Trp His Glu Val Met Asn Asn Asp Glu Trp Val Tyr Gln Tyr Pro 
        35                  40                  45              

Ile Gly Lys Phe Val Glu Arg Gln Gly Trp Lys Ile His Ile Ser Ser 
    50                  55                  60                  

Glu Tyr Asn Ser Ser His Glu Leu Leu Gln Asp Val Ala Lys Ile Cys 
65                  70                  75                  80  

His Glu Met Arg Ile Pro Phe Lys His Leu Ser Thr Glu Asp Lys Phe 
                85                  90                  95      

Ile Met Arg Asn Gly Lys Leu Val Ser Arg Gly Phe Ser Gly Lys Phe 
            100                 105                 110         

Ile Thr Cys Tyr Pro Asn Gln Asn Glu Leu Glu Ser Val Leu Gln Arg 
        115                 120                 125             

Leu Glu Ser Ala Leu Lys Gln Tyr Asn Gly Pro Tyr Ile Leu Ser Asp 
    130                 135                 140                 

Lys Arg Trp Asp Glu Ala Pro Ile Tyr Leu Arg Tyr Gly Val Phe Arg 
145                 150                 155                 160 

Pro Ser Arg Asp Asp Glu Lys Lys Val Ala Ile Asp Glu Leu Ile Val 
                165                 170                 175     

Gly Asp Glu Val Val Lys Asp Glu Arg Leu Pro Val Phe Lys Ile Pro 
            180                 185                 190         

Lys Gly Ile Val Pro Pro Asp Phe Leu Asn Lys Trp Leu Asp Lys Lys 
        195                 200                 205             

Asp Lys Lys Gln Gly Asp Phe Pro Phe Ile Ile Asp Asn Ala Ile Arg 
    210                 215                 220                 

Phe Ser Asn Ser Gly Gly Ile Tyr Asn Ala Arg Leu Lys Glu Asp Gly 
225                 230                 235                 240 

Lys Lys Ile Ile Leu Lys Glu Ala Arg Pro Tyr Thr Gly Leu Gly Phe 
                245                 250                 255     

Asp Gly Thr Tyr Ser Ser Glu Lys Leu Ala Ser Glu Cys Lys Ala Leu 
            260                 265                 270         

Lys Ile Leu Asn Glu Trp Ser Glu Thr Pro Lys Ile Tyr Trp His Gly 
        275                 280                 285             

Lys Ile Trp Glu His Thr Phe Leu Gly Ile Glu His Met Lys Gly Val 
    290                 295                 300                 

Pro Leu Asn Arg Trp Val Thr Asn Asn Phe Pro Leu Tyr Glu Val Val 
305                 310                 315                 320 

Asp Lys Thr Lys Asp Tyr Leu Leu Arg Val Ser Lys Ile Val Glu Lys 
                325                 330                 335     

Leu Ile Asp Leu Thr Asn Lys Phe His Ser Glu Asn Val Tyr His Gln 
            340                 345                 350         

Asp Leu His Leu Gly Asn Ile Leu Val Lys Asp Glu Asp Glu Ile Ser 
        355                 360                 365             

Ile Ile Asp Trp Glu Gln Ala Val Phe Ser Asn Asp Glu Lys Val Val 
    370                 375                 380                 

His Lys Val Ala Ala Pro Gly Phe Arg Ala Trp Arg Glu Thr Leu Pro 
385                 390                 395                 400 

Ser Glu Ile Asp Trp Tyr Gly Ile Arg Gln Ile Ala His Tyr Leu Tyr 
                405                 410                 415     

Met Pro Leu Val Thr Thr Ser Asp Leu Thr Tyr Asn Tyr Val Ser Gln 
            420                 425                 430         

Thr Arg Ile Glu Gly Lys Lys Leu Phe Glu Ser Leu Gly Tyr Thr Arg 
        435                 440                 445             

Glu His Ile Asp Tyr Val Glu Ser Leu Leu Ser Tyr Leu Asp Ser Lys 
    450                 455                 460                 

Cys Pro Gln Ile Glu Asn Ile Ser Arg Lys Lys Val Leu Lys Pro Met 
465                 470                 475                 480 

His Glu Ile Arg Thr Ile Glu Ser Glu Gln Asp Ile Gln Asp Phe Ile 
                485                 490                 495     

Ile Lys Leu Leu Arg Gly Phe Thr Leu Thr Tyr Gly Gln Trp Arg Lys 
            500                 505                 510         

Glu Phe Gln Ser Arg Phe Phe Pro Val His Tyr Tyr Gly Leu Asn Phe 
        515                 520                 525             

Asn Gln Gly Ile Ala Phe Ser Asp Leu Ala Ile Leu Trp Ser Tyr Gln 
    530                 535                 540                 

Gln Leu Ala Lys Lys Val Lys Asn Phe Lys Phe Asp Asp Tyr Tyr Glu 
545                 550                 555                 560 

Ile Arg Thr Gln Val Ile Asn Glu Ala Val Asn Asn Phe Lys Lys Ser 
                565                 570                 575     

Ser Leu Ser Gly Leu Phe Asp Gly Lys Ile Gly Thr Ile Trp Leu Ile 
            580                 585                 590         

Tyr Glu Phe Gly Glu Ile Asp Arg Ala Val Glu Leu Phe Thr Thr His 
        595                 600                 605             

Phe Ile Glu Ile Phe Glu Asn Ser Gln Asn Lys Asn Leu Tyr Ser Gly 
    610                 615                 620                 

Gln Ala Gly Ile Leu Leu Val Gly Leu Tyr Phe Leu Ser Lys Gly Gly 
625                 630                 635                 640 

Ile Asp Asn Lys Leu Gly Glu Glu Ile Leu Ile Arg Leu Arg Glu Tyr 
                645                 650                 655     

Thr Leu Asn Tyr Ile Glu Asn Pro Glu Thr Phe Cys Lys Val Gly Ala 
            660                 665                 670         

Ser Asp Val Gln Ser Asn Asp Pro Tyr Glu Asn Phe Gly Gly Leu Leu 
        675                 680                 685             

Tyr Gly His Ala Gly Val Ala Trp Leu Phe Gly Glu Ala Tyr Lys Leu 
    690                 695                 700                 

Thr Gly Glu Ser Ile Tyr Lys Asn Gly Leu Glu Leu Ala Val Asp Lys 
705                 710                 715                 720 

Glu Leu Val Ala Tyr Lys Val Asp Ser Asn Asn Ser Leu Gln Tyr Ser 
                725                 730                 735     

Gln Gly His Arg Leu Leu Pro Tyr Leu Ala Thr Gly Ser Ala Gly Leu 
            740                 745                 750         

Leu Leu Leu Ile Asn Arg Asn Lys Glu Ile Leu Ser Ser Lys Tyr Leu 
        755                 760                 765             

Lys Tyr Leu Thr Ser Leu Glu Arg Ala Thr Asp Val Val Phe Cys Val 
    770                 775                 780                 

Leu Pro Gly Leu Phe Asn Gly Phe Cys Gly Leu Glu Val Ala Asn Asn 
785                 790                 795                 800 

Ile Tyr Ser Asp Ile Asp Asp Asn Phe Ser Gly Gln Lys Lys Leu Ile 
                805                 810                 815     

Glu Gln Leu Tyr Arg Tyr Leu Cys Val Ile Glu Glu Gly Phe Val Ile 
            820                 825                 830         

Ala Gly Asp Asn Gly Leu Lys Ile Thr Thr Asp Ile Ala Ser Gly Phe 
        835                 840                 845             

Ala Gly Val Ala Ile Gly Leu Val Ser Ile Met Asp Asn Lys Leu Thr 
    850                 855                 860                 

Ile Leu Pro Gln Ile 
865                 

<210>   2719
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2719
ttgacgaaac agatgaagtt gatggaatgc gatttagtac attcagtaca aatcgttgcg   60
gtaactggag tgcttttagt tgggaaaatt gttaattcat ttaaattg                108

<210>   2720
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   2720
Met Thr Lys Gln Met Lys Leu Met Glu Cys Asp Leu Val His Ser Val 
1               5                   10                  15      

Gln Ile Val Ala Val Thr Gly Val Leu Leu Val Gly Lys Ile Val Asn 
            20                  25                  30          

Ser Phe Lys Leu 
        35      

<210>   2721
<211>   135
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2721
atggcagaag aagtattaaa tcttcaatta gtatctgttc aagttgacga aacagatgaa   60
gttgatggaa tgcgatttag tacattcagt acaaatcgtt gcggtaactg gagtgctttt   120
agttgggaaa attgt                                                    135

<210>   2722
<211>   45
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2722
Met Ala Glu Glu Val Leu Asn Leu Gln Leu Val Ser Val Gln Val Asp 
1               5                   10                  15      

Glu Thr Asp Glu Val Asp Gly Met Arg Phe Ser Thr Phe Ser Thr Asn 
            20                  25                  30          

Arg Cys Gly Asn Trp Ser Ala Phe Ser Trp Glu Asn Cys 
        35                  40                  45  

<210>   2723
<211>   585
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2723
atgaaaagaa taattccagt ttatatattc caacaagtaa atgtcctatt ggtatctcta   60
tacttattga aatttctttg tatcggtgag ttaactatac tacagattct ctatggttcg   120
tcactcattt cttttttatg gatgtatggc caacgcaaac aagcgcataa ggtcaatatg   180
aaatctagga tgaaatggct tggtgttgaa tttgttagcc tactgattat aagtctatgt   240
tttagtctga ttcatgctca aggaagcacg aatcaagcaa acttaattgg ccttcaacat   300
caaattcctt ggttttcatt tttattgttc ttaatcaatg cgagtatggt tgaagaattt   360
ctgtatcgag aaattttatg gaatttggtc agaaaattag atatcagagt tgctttgaca   420
agtgttttat ttgccttagc acatcataca ggaaccattc tagcttggtg tttgtatgtt   480
tcacttggga tgtttttagg tatggtgcgc tataaatctg acttatgggg cagtatggga   540
ctacatttgg tgtggaacct actagtttat agtttgctgc ttttt                   585

<210>   2724
<211>   195
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903249 (e-109)

<400>   2724
Met Lys Arg Ile Ile Pro Val Tyr Ile Phe Gln Gln Val Asn Val Leu 
1               5                   10                  15      

Leu Val Ser Leu Tyr Leu Leu Lys Phe Leu Cys Ile Gly Glu Leu Thr 
            20                  25                  30          

Ile Leu Gln Ile Leu Tyr Gly Ser Ser Leu Ile Ser Phe Leu Trp Met 
        35                  40                  45              

Tyr Gly Gln Arg Lys Gln Ala His Lys Val Asn Met Lys Ser Arg Met 
    50                  55                  60                  

Lys Trp Leu Gly Val Glu Phe Val Ser Leu Leu Ile Ile Ser Leu Cys 
65                  70                  75                  80  

Phe Ser Leu Ile His Ala Gln Gly Ser Thr Asn Gln Ala Asn Leu Ile 
                85                  90                  95      

Gly Leu Gln His Gln Ile Pro Trp Phe Ser Phe Leu Leu Phe Leu Ile 
            100                 105                 110         

Asn Ala Ser Met Val Glu Glu Phe Leu Tyr Arg Glu Ile Leu Trp Asn 
        115                 120                 125             

Leu Val Arg Lys Leu Asp Ile Arg Val Ala Leu Thr Ser Val Leu Phe 
    130                 135                 140                 

Ala Leu Ala His His Thr Gly Thr Ile Leu Ala Trp Cys Leu Tyr Val 
145                 150                 155                 160 

Ser Leu Gly Met Phe Leu Gly Met Val Arg Tyr Lys Ser Asp Leu Trp 
                165                 170                 175     

Gly Ser Met Gly Leu His Leu Val Trp Asn Leu Leu Val Tyr Ser Leu 
            180                 185                 190         

Leu Leu Phe 
        195 

<210>   2725
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2725
atggctgaac gattttggga gaacttgtcc attattttgg ctgaaagaaa tatcagctgg   60
attgagttaa ccagaaaaat gtttgcggga gagtttcact atccaagtga attgaatcgt   120
ttgtatcaaa agattcgcca c                                             141

<210>   2726
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2726
Met Ala Glu Arg Phe Trp Glu Asn Leu Ser Ile Ile Leu Ala Glu Arg 
1               5                   10                  15      

Asn Ile Ser Trp Ile Glu Leu Thr Arg Lys Met Phe Ala Gly Glu Phe 
            20                  25                  30          


His Tyr Pro Ser Glu Leu Asn Arg Leu Tyr Gln Lys Ile Arg His 
        35                  40                  45          

<210>   2727
<211>   378
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2727
atgattgatc tctatctaag taaaaataga caaagaaatc aacttctttt agatttcttc   60
caaaactatg gcatagaggt atcttgtcat tcagtttctg aaatgacaaa ggacaaatta   120
attgagatga tgagctattc ttcagattgt tttgagtttt tatctcccaa tttattacga   180
tttaagaacc gtgacaatct aagattaacg gatttcgttg agataatttt aaaaaatcct   240
gaactaacca tcagacttcc tcttgcggtt tcaaataagc gagtttatcc aagtctgaat   300
ttggaagagg ctagagctct attgccaaga gatacgaaac aattgattta catggcgcaa   360
acacattatt tatctaac                                                 378

<210>   2728
<211>   126
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903250 (7.E-69)

<400>   2728
Met Ile Asp Leu Tyr Leu Ser Lys Asn Arg Gln Arg Asn Gln Leu Leu 
1               5                   10                  15      

Leu Asp Phe Phe Gln Asn Tyr Gly Ile Glu Val Ser Cys His Ser Val 
            20                  25                  30          

Ser Glu Met Thr Lys Asp Lys Leu Ile Glu Met Met Ser Tyr Ser Ser 
        35                  40                  45              

Asp Cys Phe Glu Phe Leu Ser Pro Asn Leu Leu Arg Phe Lys Asn Arg 
    50                  55                  60                  

Asp Asn Leu Arg Leu Thr Asp Phe Val Glu Ile Ile Leu Lys Asn Pro 
65                  70                  75                  80  

Glu Leu Thr Ile Arg Leu Pro Leu Ala Val Ser Asn Lys Arg Val Tyr 
                85                  90                  95      

Pro Ser Leu Asn Leu Glu Glu Ala Arg Ala Leu Leu Pro Arg Asp Thr 
            100                 105                 110         

Lys Gln Leu Ile Tyr Met Ala Gln Thr His Tyr Leu Ser Asn 
        115                 120                 125     

<210>   2729
<211>   276
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2729
gtgacatttt tagatgatta ccataaaaaa cataactacc cactatttta cgaatcctat   60
cttcaaaacg ttatggaatt ccttgaaagt caagacataa agaatggggt tgatgccttt   120
gtagatgatc atcaaaatct cgtttttgtt ttatatggac aaggctatcg agccgaggga   180
aaagagggaa tacttacaac ccaagtaact gtaaaagctt atgatgaaga caagaaaccg   240

attaacttcg caaatttatt agattcctta atttat                             276

<210>   2730
<211>   92
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903251 (4.E-51)

<400>   2730
Met Thr Phe Leu Asp Asp Tyr His Lys Lys His Asn Tyr Pro Leu Phe 
1               5                   10                  15      

Tyr Glu Ser Tyr Leu Gln Asn Val Met Glu Phe Leu Glu Ser Gln Asp 
            20                  25                  30          

Ile Lys Asn Gly Val Asp Ala Phe Val Asp Asp His Gln Asn Leu Val 
        35                  40                  45              

Phe Val Leu Tyr Gly Gln Gly Tyr Arg Ala Glu Gly Lys Glu Gly Ile 
    50                  55                  60                  

Leu Thr Thr Gln Val Thr Val Lys Ala Tyr Asp Glu Asp Lys Lys Pro 
65                  70                  75                  80  

Ile Asn Phe Ala Asn Leu Leu Asp Ser Leu Ile Tyr 
                85                  90          

<210>   2731
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2731
atgaagcgta ttaccgctaa tcaatatcag acatcagagc gttattataa gctccccaaa   60
cttttatttg agagtgaacg gtataagaat atgaaactgg aggttaaggt ggtttactca   120
gttttaaaag atcggttgga gttgtctttg agcaaaggtt ggattgatga ggatggggct   180
atttatttga tttattccaa ttcaaatttg atggcacttt taggctgttc aaagtcaaaa   240
ttactctcca tg                                                       252

<210>   2732
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903252 (1.E-43)

<400>   2732
Met Lys Arg Ile Thr Ala Asn Gln Tyr Gln Thr Ser Glu Arg Tyr Tyr 
1               5                   10                  15      

Lys Leu Pro Lys Leu Leu Phe Glu Ser Glu Arg Tyr Lys Asn Met Lys 
            20                  25                  30          

Leu Glu Val Lys Val Val Tyr Ser Val Leu Lys Asp Arg Leu Glu Leu 
        35                  40                  45              

Ser Leu Ser Lys Gly Trp Ile Asp Glu Asp Gly Ala Ile Tyr Leu Ile 
    50                  55                  60                  

Tyr Ser Asn Ser Asn Leu Met Ala Leu Leu Gly Cys Ser Lys Ser Lys 
65                  70                  75                  80  

Leu Leu Ser Met 
                

<210>   2733
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2733
atgatttggg taaaagcaac tcagttagtt gatgaaatgg aacaagtagg tttaatccga   60
tttgatgaat ttggaaatgt tggaatttta gtcttggagg gacaa                   105

<210>   2734
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2734
Met Ile Trp Val Lys Ala Thr Gln Leu Val Asp Glu Met Glu Gln Val 
1               5                   10                  15      

Gly Leu Ile Arg Phe Asp Glu Phe Gly Asn Val Gly Ile Leu Val Leu 
            20                  25                  30          

Glu Gly Gln 
        35  

<210>   2735
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2735
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattgtt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg tgggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   2736
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903941 (2.E-46)

<400>   2736
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   2737
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2737
ttgcggaatc cctatttacc agtctttgag agcgataagc gattgataga aactgataaa   60
ttgatttggt ttcctgccaa aaattctttg gcaggatttt tgttt                   105

<210>   2738
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   2738
Met Arg Asn Pro Tyr Leu Pro Val Phe Glu Ser Asp Lys Arg Leu Ile 
1               5                   10                  15      

Glu Thr Asp Lys Leu Ile Trp Phe Pro Ala Lys Asn Ser Leu Ala Gly 
            20                  25                  30          

Phe Leu Phe 
        35  

<210>   2739
<211>   381
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2739
ttggaggaaa taacaatggc attgaacatt gaaaacatta ttgctgaaat taaagaagct   60
tcaatccttg aattgaacga ccttgtaaaa gctatcgaag aagaatttgg tgtaactgca   120
gctgctcctg tagctgttgc tgcagctgat gcagctgatg ctggtgctgc taaagattca   180
ttcgacgttg aattgacatc tgcaggcgac aaaaaagttg gcgttatcaa agttgtacgt   240
gaaatcactg gtcttggtct taaagaagct aaagaacttg ttgacggtgc accagcactt   300
gttaaagaag gcgttgcaac tgcagaagct gaagaaatca aagctaaatt ggaagaagct   360
ggagcttcag ttactcttaa a                                             381

<210>   2740
<211>   127
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L7/L12 (rplL)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903254 (7.E-61)

<400>   2740
Met Glu Glu Ile Thr Met Ala Leu Asn Ile Glu Asn Ile Ile Ala Glu 
1               5                   10                  15      

Ile Lys Glu Ala Ser Ile Leu Glu Leu Asn Asp Leu Val Lys Ala Ile 
            20                  25                  30          

Glu Glu Glu Phe Gly Val Thr Ala Ala Ala Pro Val Ala Val Ala Ala 
        35                  40                  45              

Ala Asp Ala Ala Asp Ala Gly Ala Ala Lys Asp Ser Phe Asp Val Glu 
    50                  55                  60                  

Leu Thr Ser Ala Gly Asp Lys Lys Val Gly Val Ile Lys Val Val Arg 
65                  70                  75                  80  

Glu Ile Thr Gly Leu Gly Leu Lys Glu Ala Lys Glu Leu Val Asp Gly 
                85                  90                  95      

Ala Pro Ala Leu Val Lys Glu Gly Val Ala Thr Ala Glu Ala Glu Glu 
            100                 105                 110         

Ile Lys Ala Lys Leu Glu Glu Ala Gly Ala Ser Val Thr Leu Lys 
        115                 120                 125         

<210>   2741
<211>   561
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2741
ttgggcgcgt ttttcttttt gaaaaattcc ccaagcaaaa taattacgga ggtgaacaca   60
ctaatgagtg aagcaattat tgctaaaaaa gcggaactag ttgacgtagt agctgaaaaa   120
atgaaagctg ctgcatctat cgtcgttgta gacgctcgtg gtttgacagt tgagcaagat   180
acagttcttc gtcgtgagct tcgtggaagc gaagttgagt ataaagttat taaaaactca   240
atcttgcgtc gtgcagctga aaaagctggt cttgaagatc ttgcatctgt atttgttgga   300
ccatctgcag tagcattttc taatgaagat gttatcgcac cagcgaaaat cttgaacgac   360
ttttctaaaa acgctgaagc acttgaaatt aaaggtggtg caatcgaagg cgctgtcgca   420
tctaaagaag agattcttgc acttgcaact cttccaaacc gcgaaggact tctttctatg   480
ctcctttctg tacttcaagc gccagtgcgc aacgttgctc ttgcagtcaa agcggttgca   540
gaaagcaaag aagacgcggc t                                             561

<210>   2742
<211>   187
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L10 (rplJ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903255 (4.E-84)

<400>   2742
Met Gly Ala Phe Phe Phe Leu Lys Asn Ser Pro Ser Lys Ile Ile Thr 
1               5                   10                  15      

Glu Val Asn Thr Leu Met Ser Glu Ala Ile Ile Ala Lys Lys Ala Glu 
            20                  25                  30          

Leu Val Asp Val Val Ala Glu Lys Met Lys Ala Ala Ala Ser Ile Val 
        35                  40                  45              

Val Val Asp Ala Arg Gly Leu Thr Val Glu Gln Asp Thr Val Leu Arg 
    50                  55                  60                  

Arg Glu Leu Arg Gly Ser Glu Val Glu Tyr Lys Val Ile Lys Asn Ser 
65                  70                  75                  80  

Ile Leu Arg Arg Ala Ala Glu Lys Ala Gly Leu Glu Asp Leu Ala Ser 
                85                  90                  95      

Val Phe Val Gly Pro Ser Ala Val Ala Phe Ser Asn Glu Asp Val Ile 
            100                 105                 110         

Ala Pro Ala Lys Ile Leu Asn Asp Phe Ser Lys Asn Ala Glu Ala Leu 
        115                 120                 125             

Glu Ile Lys Gly Gly Ala Ile Glu Gly Ala Val Ala Ser Lys Glu Glu 
    130                 135                 140                 

Ile Leu Ala Leu Ala Thr Leu Pro Asn Arg Glu Gly Leu Leu Ser Met 
145                 150                 155                 160 

Leu Leu Ser Val Leu Gln Ala Pro Val Arg Asn Val Ala Leu Ala Val 
                165                 170                 175     

Lys Ala Val Ala Glu Ser Lys Glu Asp Ala Ala 
            180                 185         

<210>   2743
<211>   321
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2743
atgtttgagg aaggaaggac tgcagctctt cttcagaaga tgaaaagtgg ggatgccagc   60
cagtttccaa tcgaaacagc tctcaaggta ctgacaatcg aaggggctaa ggtccttgga   120
atggaaaatc agataggaag tctggaagtc ggcaagcaag cagattttct ggtcattcaa   180
ccacaaggga aaattcatct ccaacctcag gaaaatatgc tgtctcacct ggtttatgca   240
gttaaatcta gtgatgtaga tgatgtttat atcgccggag aacaggttgt taagcaaggt   300
caagtcctga cagtagaact t                                             321

<210>   2744
<211>   107
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein

<400>   2744
Met Phe Glu Glu Gly Arg Thr Ala Ala Leu Leu Gln Lys Met Lys Ser 
1               5                   10                  15      

Gly Asp Ala Ser Gln Phe Pro Ile Glu Thr Ala Leu Lys Val Leu Thr 
            20                  25                  30          

Ile Glu Gly Ala Lys Val Leu Gly Met Glu Asn Gln Ile Gly Ser Leu 
        35                  40                  45              

Glu Val Gly Lys Gln Ala Asp Phe Leu Val Ile Gln Pro Gln Gly Lys 
    50                  55                  60                  

Ile His Leu Gln Pro Gln Glu Asn Met Leu Ser His Leu Val Tyr Ala 
65                  70                  75                  80  

Val Lys Ser Ser Asp Val Asp Asp Val Tyr Ile Ala Gly Glu Gln Val 
                85                  90                  95      

Val Lys Gln Gly Gln Val Leu Thr Val Glu Leu 
            100                 105         

<210>   2745
<211>   1256
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2745
atgaaagtct ttcagcatgt aaatatcgtg acttgtgatc aagatttcca tgtttatctt   60
gatggaatct tagcagtcaa ggattctcaa atcgtctatg tcggtcaaga taagccagcg   120
tttttagagc aagctgagca gattatagac tatcagggag cttggattat gcctggtttg   180
gtcaattgtc acacccattc tgcaatgaca ggtctgagag ggatccgaga tgacagcaat   240
ctccatgaat ggctcaatga ctatatttgg ccagcagaat ctgagtttac tcccgacatg   300
actaccaatg cggtcaaaga agccctgaca gagatgctcc agtcaggaac aacaaccttt   360
aacgatatgt ataatcccaa tggtgtggat atccagcaaa tttatcaggt ggtgaaaact   420
tccaagatgc gttgttattt ttctccgact ctcttttctt cagagacaga aacaactgct   480
gagactataa gtagaactcg atccatcata gacgaaatct taaaatataa aaatccaaat   540
ttcaaggtta tggtagcacc tcattctccg tatagctgca gtagagactt gctggaagcg   600
agtttggaaa tggcaaaaga gctaaatatt ccgctccatg tccatgtggc ggagaccaag   660
gaggagtcag gaattatcct caaacgatac ggcaaacgcc cccttgcttt tcttgaagaa   720
ctgggttatt tagatcatcc gtccgtattt gctcacgggg tcgaattaaa cgagagagaa   780
attgaacgct tggcatcttc tcaagtgcta tcgcccacaa tcctatcagt aacctcaaac   840
tggcatcagg aattgctcca attatccagc tccaaaaagc gggagtagca gtcggaattg   900
cgactgactc ggttgcttcc aataacaatc tagatatgtt tgaggaagga aggactgcag   960
ctcttcttca gaagatgaaa agtggggatg ccagccagtt tccaatcgaa acagctctca   1020
aggtactgac aatcgaaggg gctaaggtcc ttggaatgga aaatcagata ggaagtctgg   1080
aagtcggcaa gcaagcagat tttctggtca ttcaaccaca agggaaaatt catctccaac   1140

ctcaggaaaa tatgctgtct cacctggttt atgcagttaa atctagtgat gtagatgatg   1200
tttatatcgc cggagaacag gttgttaagc aaggtcaagt cctgacagta gaactt       1256

<210>   2746
<211>   394
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Atz/Trz family protein, FRAMESHIFT

<400>   2746
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Val Gly Cys Ser Lys 
1               5                   10                  15      

His Ser Phe Glu Val Val Asp Lys Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Cys Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys 
        35                  40                  45              

Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys Phe 
    50                  55                  60                  

Glu Val Ala Asp Arg Thr Asp Glu Val Ser Asn His Thr Tyr Gly Lys 
65                  70                  75                  80  

Val Asn Leu Lys Trp Phe Glu Glu Ser Thr Thr Cys Leu Leu Glu Lys 
                85                  90                  95      

Glu Pro Ile Met Lys Val Phe Gln His Val Asn Ile Val Thr Cys Asp 
            100                 105                 110         

Gln Asp Phe His Val Tyr Leu Asp Gly Ile Leu Ala Val Lys Asp Ser 
        115                 120                 125             

Gln Ile Val Tyr Val Gly Gln Asp Lys Pro Ala Phe Leu Glu Gln Ala 
    130                 135                 140                 

Glu Gln Ile Ile Asp Tyr Gln Gly Ala Trp Ile Met Pro Gly Leu Val 
145                 150                 155                 160 

Asn Cys His Thr His Ser Ala Met Thr Gly Leu Arg Gly Ile Arg Asp 
                165                 170                 175     

Asp Ser Asn Leu His Glu Trp Leu Asn Asp Tyr Ile Trp Pro Ala Glu 
            180                 185                 190         

Ser Glu Phe Thr Pro Asp Met Thr Thr Asn Ala Val Lys Glu Ala Leu 
        195                 200                 205             

Thr Glu Met Leu Gln Ser Gly Thr Thr Thr Phe Asn Asp Met Tyr Asn 
    210                 215                 220                 

Pro Asn Gly Val Asp Ile Gln Gln Ile Tyr Gln Val Val Lys Thr Ser 
225                 230                 235                 240 

Lys Met Arg Cys Tyr Phe Ser Pro Thr Leu Phe Ser Ser Glu Thr Glu 
                245                 250                 255     

Thr Thr Ala Glu Thr Ile Ser Arg Thr Arg Ser Ile Ile Asp Glu Ile 
            260                 265                 270         

Leu Lys Tyr Lys Asn Pro Asn Phe Lys Val Met Val Ala Pro His Ser 
        275                 280                 285             

Pro Tyr Ser Cys Ser Arg Asp Leu Leu Glu Ala Ser Leu Glu Met Ala 
    290                 295                 300                 

Lys Glu Leu Asn Ile Pro Leu His Val His Val Ala Glu Thr Lys Glu 
305                 310                 315                 320 

Glu Ser Gly Ile Ile Leu Lys Arg Tyr Gly Lys Arg Pro Leu Ala Phe 
                325                 330                 335     

Leu Glu Glu Leu Gly Tyr Leu Asp His Pro Ser Val Phe Ala His Gly 
            340                 345                 350         

Val Glu Leu Asn Glu Arg Glu Ile Glu Arg Leu Ala Ser Ser Gln Val 
        355                 360                 365             

Leu Ser Pro Thr Ile Leu Ser Val Thr Ser Asn Trp His Gln Glu Leu 
    370                 375                 380                 

Leu Gln Leu Ser Ser Ser Lys Lys Arg Glu 
385                 390                 

<210>   2747
<211>   1788
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2747
gtgaaatcaa tgcatcccaa catggaaagg aggactagaa tgaaacgaca aactgtaaac   60
cagacgctca aacgtttagc cgtagattta gcaagccatc ctttcctcct tttcctagcc   120
tttctaggaa ctattgccca agttggctta tcaatttacc tacctattct gattgggcag   180
gtcattgacc aagtcctagt ggctggttca tcaccagttt tttggcagat ttttctccag   240
atgctcttgg tggtaatagg aaatactctg gtacaatggg ccaatcctct cctctataat   300
cgtctaatct tctcttatac cagagattta cgggagcgaa tcatccataa gctccatcgt   360
ttaccgattg cctttgtaga taggcaaggt agtggagaga tggttagtcg tgtaaccacg   420
gacatcgaac agttggcagc tggcttgacc atgattttta accaattttt cattggtgtt   480
ttgatgattt tggtcagtat tctagccatg ctccaaattc atctcctcat gactctctta   540
gtcttgctgt tgacgccact gtccatggtg atttcacgct ttattgccaa gaaatcctat   600
catctcttcc agaagcaaac agagacgagg ggaattcaga ctcagttgat tgaagaatcg   660
cttagtcagc agactataat ccagtccttc aatgctcaaa cagaatttat ccaaagattg   720
cgtgaggctc atgacaacta ctcaggctat tctcagtcag ccatctttta ttcttcaacg   780
gtcaatcctt cgactcgctt tgtaaatgca ctcatttatg cccttttagc tggagtagga   840
gcttatcgta tcatgatggg ttcagccttg accgtcggtc gtttagtgac ttttttgaac   900
tatgttcagc aatacaccaa gccctttaac gatatttctt cagtgctagc tgagttgcaa   960
agtgctctgg cttgcgtaga gcgtatctat ggagtcttag atagccctga agtggctgaa   1020
acaggtaagg aagtcttgac gaccagtgac caagttaagg gagctatttc ctttaaacat   1080
gtctcttttg gctaccatcc tgaaaaaatt ttgattaagg acttgtctat cgatattcca   1140
gctggtagta aggtagccat cgttggtccg acaggtgctg gaaaatcaac tcttatcaat   1200
ctccttatgc gtttttatcc cattagctcg ggagatatct tgctggatgg gcaatccatt   1260
tatgattata cacgagtatc attgagacag cagtttggta tggtgcttca agaaacctgg   1320
ctcacacaag ggaccattca tgataatatt gcctttggca atcctgaagc cagtcgagag   1380
caagtaattg ctgctgccaa agcagctaat gcagactttt tcatccaaca gttgccacag   1440
ggatacgata ccaagttgga aaatgctgga gaatctctct ctgtcggcca agctcagctc   1500
ttgaccatag cccgagtctt tctggctatt ccaaagattc ttatcttaga cgaggcaact   1560
tcttccattg atacacggac agaagtgctg gtacaggatg cctttgcaaa actcatgaag   1620
ggccgcacaa gtttcatcat tgctcaccgt ttgtcaacca ttcaggatgc ggatttaatt   1680
cttgtcttag tagatggtga tattgttgaa tatggtaacc atcaagaact catggataga   1740
aagggtaagt attaccaaat gcaaaaagct gcggctttta gttctgaa                1788

<210>   2748
<211>   596
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903257 (0.E+01)

<400>   2748
Met Lys Ser Met His Pro Asn Met Glu Arg Arg Thr Arg Met Lys Arg 
1               5                   10                  15      

Gln Thr Val Asn Gln Thr Leu Lys Arg Leu Ala Val Asp Leu Ala Ser 
            20                  25                  30          

His Pro Phe Leu Leu Phe Leu Ala Phe Leu Gly Thr Ile Ala Gln Val 
        35                  40                  45              

Gly Leu Ser Ile Tyr Leu Pro Ile Leu Ile Gly Gln Val Ile Asp Gln 
    50                  55                  60                  

Val Leu Val Ala Gly Ser Ser Pro Val Phe Trp Gln Ile Phe Leu Gln 
65                  70                  75                  80  

Met Leu Leu Val Val Ile Gly Asn Thr Leu Val Gln Trp Ala Asn Pro 
                85                  90                  95      

Leu Leu Tyr Asn Arg Leu Ile Phe Ser Tyr Thr Arg Asp Leu Arg Glu 
            100                 105                 110         

Arg Ile Ile His Lys Leu His Arg Leu Pro Ile Ala Phe Val Asp Arg 
        115                 120                 125             

Gln Gly Ser Gly Glu Met Val Ser Arg Val Thr Thr Asp Ile Glu Gln 
    130                 135                 140                 

Leu Ala Ala Gly Leu Thr Met Ile Phe Asn Gln Phe Phe Ile Gly Val 
145                 150                 155                 160 

Leu Met Ile Leu Val Ser Ile Leu Ala Met Leu Gln Ile His Leu Leu 
                165                 170                 175     

Met Thr Leu Leu Val Leu Leu Leu Thr Pro Leu Ser Met Val Ile Ser 
            180                 185                 190         

Arg Phe Ile Ala Lys Lys Ser Tyr His Leu Phe Gln Lys Gln Thr Glu 
        195                 200                 205             

Thr Arg Gly Ile Gln Thr Gln Leu Ile Glu Glu Ser Leu Ser Gln Gln 
    210                 215                 220                 

Thr Ile Ile Gln Ser Phe Asn Ala Gln Thr Glu Phe Ile Gln Arg Leu 
225                 230                 235                 240 

Arg Glu Ala His Asp Asn Tyr Ser Gly Tyr Ser Gln Ser Ala Ile Phe 
                245                 250                 255     

Tyr Ser Ser Thr Val Asn Pro Ser Thr Arg Phe Val Asn Ala Leu Ile 
            260                 265                 270         

Tyr Ala Leu Leu Ala Gly Val Gly Ala Tyr Arg Ile Met Met Gly Ser 
        275                 280                 285             

Ala Leu Thr Val Gly Arg Leu Val Thr Phe Leu Asn Tyr Val Gln Gln 
    290                 295                 300                 

Tyr Thr Lys Pro Phe Asn Asp Ile Ser Ser Val Leu Ala Glu Leu Gln 
305                 310                 315                 320 

Ser Ala Leu Ala Cys Val Glu Arg Ile Tyr Gly Val Leu Asp Ser Pro 
                325                 330                 335     

Glu Val Ala Glu Thr Gly Lys Glu Val Leu Thr Thr Ser Asp Gln Val 
            340                 345                 350         

Lys Gly Ala Ile Ser Phe Lys His Val Ser Phe Gly Tyr His Pro Glu 
        355                 360                 365             

Lys Ile Leu Ile Lys Asp Leu Ser Ile Asp Ile Pro Ala Gly Ser Lys 
    370                 375                 380                 

Val Ala Ile Val Gly Pro Thr Gly Ala Gly Lys Ser Thr Leu Ile Asn 
385                 390                 395                 400 

Leu Leu Met Arg Phe Tyr Pro Ile Ser Ser Gly Asp Ile Leu Leu Asp 
                405                 410                 415     

Gly Gln Ser Ile Tyr Asp Tyr Thr Arg Val Ser Leu Arg Gln Gln Phe 
            420                 425                 430         

Gly Met Val Leu Gln Glu Thr Trp Leu Thr Gln Gly Thr Ile His Asp 
        435                 440                 445             

Asn Ile Ala Phe Gly Asn Pro Glu Ala Ser Arg Glu Gln Val Ile Ala 
    450                 455                 460                 

Ala Ala Lys Ala Ala Asn Ala Asp Phe Phe Ile Gln Gln Leu Pro Gln 
465                 470                 475                 480 

Gly Tyr Asp Thr Lys Leu Glu Asn Ala Gly Glu Ser Leu Ser Val Gly 
                485                 490                 495     

Gln Ala Gln Leu Leu Thr Ile Ala Arg Val Phe Leu Ala Ile Pro Lys 
            500                 505                 510         

Ile Leu Ile Leu Asp Glu Ala Thr Ser Ser Ile Asp Thr Arg Thr Glu 
        515                 520                 525             

Val Leu Val Gln Asp Ala Phe Ala Lys Leu Met Lys Gly Arg Thr Ser 
    530                 535                 540                 

Phe Ile Ile Ala His Arg Leu Ser Thr Ile Gln Asp Ala Asp Leu Ile 
545                 550                 555                 560 

Leu Val Leu Val Asp Gly Asp Ile Val Glu Tyr Gly Asn His Gln Glu 
                565                 570                 575     

Leu Met Asp Arg Lys Gly Lys Tyr Tyr Gln Met Gln Lys Ala Ala Ala 
            580                 585                 590         

Phe Ser Ser Glu 
        595     

<210>   2749
<211>   1722
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2749
atgaaacacc tattatctta cttcaaaccc tacatcaagg aatcaatttt agcccccttg   60
ttcaagctgt tagaagctgt ttttgagctc ttggttccca tggtgattgc tgggattgtt   120
gaccaatctt tacctcaggg agatcaaggt catctctgga tgcagattgg cctgctcctt   180
atctttgcag taattggcgt tttagtggcc ttgatagctc aattttactc agcaaaggca   240
gcagtaggtt ctgctaagga attgacaaac gatctttatc gtcatattct ttccttgccc   300
aaggacagca gagaccgtct gacaacttct agtttggtca ctcgcttgac ttcggatacc   360
taccagattc agactggtat caatcaattc ctgcgtctct ttttacgagc gcccattatc   420
gtttttggtg ccatttttat ggcttatcga atctcagctg agttgacttt ctggttctta   480
gtcttggttg ccattttgac cattgtcatt gtagggttat ctcgattggt caatcctttc   540
tacagtagtc tcagaaagaa aacggaccaa ctggttcagg aaacgcgcca gcaattgcaa   600
gggatgcggg ttattcgtgc ttttggtcaa gaaaaacgag agttacagat ttttcaaacc   660
cttaaccaag tttatgctag attacaagaa aagacaggtt tctggtctag tttattaaca   720
cctctgacct atctgattgt caatggaact cttctcgtta ttatctggca aggctatatt   780
tcaattcaag gaggagtgct cagtcaaggt gctctcattg ctcttatcaa ttacctctta   840
cagattttgg tggaattggt caagctagcc atgttgatca attccctcaa ccagtcctat   900
atctcagtca agcgaatcga ggaagtcttt gttgaggctc cagaggatat ccattcagag   960
ttagaacaaa agcaagctac cagagataag gttttacaag tccaagaatt gacctttacc   1020
tatcctgatg cggcccagcc ttctctgaga tacatttcct ttgatatgac tcaaggacaa   1080
attctaggta tcatcggggg aactggttct ggtaaatcaa gcttggtgca actcttactt   1140
ggactttatc cagtagacaa ggggaacatt gacctttatc aaaatggacg tagtcctctt   1200
aatttggagc agtggcggtc ttggattgcc tatgtacctc aaaaggtcga actctttaaa   1260
ggaaccattc gttccaactt gactctaggt ttcaatcaag aagtatctga ccaggaactc   1320
tggcaggcct tggagattgc gcaagctaag gattttgtca gtgaaaagga aggactcttg   1380
gatgctctag ttgaggcagg ggggcgaaat ttctcaggtg gacaaaaaca aagattgtct   1440
atcgcccgag cagtcttgcg ccaggctccg tttctcatcc tagatgatgc aacctcggca   1500
ctggatacca ttacagagtc caagctcttg aaagctatta gagaaaattt tccaaacacg   1560
agcttaattt tgatctctca acgaacctca actttacaga tggcggacca gattctcctc   1620
ttggaaaaag gtgagttgct agctgttggc aagcacgatg acttgatgaa atccagccaa   1680
gtctattgtg aaatcaatgc atcccaacat ggaaaggagg ac                      1722

<210>   2750
<211>   574
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903259 (0.E+01)

<400>   2750
Met Lys His Leu Leu Ser Tyr Phe Lys Pro Tyr Ile Lys Glu Ser Ile 
1               5                   10                  15      

Leu Ala Pro Leu Phe Lys Leu Leu Glu Ala Val Phe Glu Leu Leu Val 
            20                  25                  30          

Pro Met Val Ile Ala Gly Ile Val Asp Gln Ser Leu Pro Gln Gly Asp 
        35                  40                  45              

Gln Gly His Leu Trp Met Gln Ile Gly Leu Leu Leu Ile Phe Ala Val 
    50                  55                  60                  

Ile Gly Val Leu Val Ala Leu Ile Ala Gln Phe Tyr Ser Ala Lys Ala 
65                  70                  75                  80  

Ala Val Gly Ser Ala Lys Glu Leu Thr Asn Asp Leu Tyr Arg His Ile 
                85                  90                  95      

Leu Ser Leu Pro Lys Asp Ser Arg Asp Arg Leu Thr Thr Ser Ser Leu 
            100                 105                 110         

Val Thr Arg Leu Thr Ser Asp Thr Tyr Gln Ile Gln Thr Gly Ile Asn 
        115                 120                 125             

Gln Phe Leu Arg Leu Phe Leu Arg Ala Pro Ile Ile Val Phe Gly Ala 
    130                 135                 140                 

Ile Phe Met Ala Tyr Arg Ile Ser Ala Glu Leu Thr Phe Trp Phe Leu 
145                 150                 155                 160 

Val Leu Val Ala Ile Leu Thr Ile Val Ile Val Gly Leu Ser Arg Leu 
                165                 170                 175     

Val Asn Pro Phe Tyr Ser Ser Leu Arg Lys Lys Thr Asp Gln Leu Val 
            180                 185                 190         

Gln Glu Thr Arg Gln Gln Leu Gln Gly Met Arg Val Ile Arg Ala Phe 
        195                 200                 205             

Gly Gln Glu Lys Arg Glu Leu Gln Ile Phe Gln Thr Leu Asn Gln Val 
    210                 215                 220                 

Tyr Ala Arg Leu Gln Glu Lys Thr Gly Phe Trp Ser Ser Leu Leu Thr 
225                 230                 235                 240 

Pro Leu Thr Tyr Leu Ile Val Asn Gly Thr Leu Leu Val Ile Ile Trp 
                245                 250                 255     

Gln Gly Tyr Ile Ser Ile Gln Gly Gly Val Leu Ser Gln Gly Ala Leu 
            260                 265                 270         

Ile Ala Leu Ile Asn Tyr Leu Leu Gln Ile Leu Val Glu Leu Val Lys 
        275                 280                 285             

Leu Ala Met Leu Ile Asn Ser Leu Asn Gln Ser Tyr Ile Ser Val Lys 
    290                 295                 300                 

Arg Ile Glu Glu Val Phe Val Glu Ala Pro Glu Asp Ile His Ser Glu 
305                 310                 315                 320 

Leu Glu Gln Lys Gln Ala Thr Arg Asp Lys Val Leu Gln Val Gln Glu 
                325                 330                 335     

Leu Thr Phe Thr Tyr Pro Asp Ala Ala Gln Pro Ser Leu Arg Tyr Ile 
            340                 345                 350         

Ser Phe Asp Met Thr Gln Gly Gln Ile Leu Gly Ile Ile Gly Gly Thr 
        355                 360                 365             

Gly Ser Gly Lys Ser Ser Leu Val Gln Leu Leu Leu Gly Leu Tyr Pro 
    370                 375                 380                 

Val Asp Lys Gly Asn Ile Asp Leu Tyr Gln Asn Gly Arg Ser Pro Leu 
385                 390                 395                 400 

Asn Leu Glu Gln Trp Arg Ser Trp Ile Ala Tyr Val Pro Gln Lys Val 
                405                 410                 415     

Glu Leu Phe Lys Gly Thr Ile Arg Ser Asn Leu Thr Leu Gly Phe Asn 
            420                 425                 430         

Gln Glu Val Ser Asp Gln Glu Leu Trp Gln Ala Leu Glu Ile Ala Gln 
        435                 440                 445             

Ala Lys Asp Phe Val Ser Glu Lys Glu Gly Leu Leu Asp Ala Leu Val 
    450                 455                 460                 

Glu Ala Gly Gly Arg Asn Phe Ser Gly Gly Gln Lys Gln Arg Leu Ser 
465                 470                 475                 480 

Ile Ala Arg Ala Val Leu Arg Gln Ala Pro Phe Leu Ile Leu Asp Asp 
                485                 490                 495     

Ala Thr Ser Ala Leu Asp Thr Ile Thr Glu Ser Lys Leu Leu Lys Ala 
            500                 505                 510         

Ile Arg Glu Asn Phe Pro Asn Thr Ser Leu Ile Leu Ile Ser Gln Arg 
        515                 520                 525             

Thr Ser Thr Leu Gln Met Ala Asp Gln Ile Leu Leu Leu Glu Lys Gly 
    530                 535                 540                 

Glu Leu Leu Ala Val Gly Lys His Asp Asp Leu Met Lys Ser Ser Gln 
545                 550                 555                 560 

Val Tyr Cys Glu Ile Asn Ala Ser Gln His Gly Lys Glu Asp 
                565                 570                 

<210>   2751
<211>   936
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2751
atggcagaaa tttatctagc aggtggttgt ttttggggcc tagaggaata tttttcacgc   60
atttctggag tgctagaaac cagtgttggc tacgctaatg gtcaagtcga aacgaccaat   120
taccagttgc tcaaggaaac agaccatgca gaaacggtcc aagtgattta cgatgagaag   180
gaagtgtcac tcagagagat tttactttat tatttccgag ttatcgatcc tctatctatc   240
aatcaacaag ggaatgaccg tggtcgccaa tatcgaactg ggatttatta tcaggatgaa   300
gcagatttgc cagctatcta cacagtggtg caggagcagg aacgcatgct gggtcgaaag   360
attgcagtag aagtggagca attacgccac tacattctgg ctgaagacta ccaccaagac   420
tatctcagga agaatccttc aggttactgt catatcgatg tgaccgatgc tgataagcca   480
ttgattgatg cagcaaacta tgaaaagcct agtcaagagg tgttgaaggc cagtctatct   540
gaagagtctt atcgtgtcac acaagaagct gctacagagg ctccatttac caatgcctat   600
gaccaaacct ttgaagaggg gatttatgta gatattacga caggtgagcc actctttttt   660
gccaaggata agtttgcttc aggttgtggt tggccaagtt ttagccgtcc gatttccaaa   720
gagttgattc attattacaa ggatctgagc catggaatgg agcgaattga agttcgttct   780
cgttcaggca gtgctcactt gggtcatgtt ttcacagatg gaccgcggga gttaggcggc   840
ctccgttact gtatcaattc tgcttcttta cgctttgtgg ccaaggatga gatggaaaaa   900
gcaggatatg gctatctatt gccttactta aacaaa                             936

<210>   2752
<211>   312
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptide methionine sulfoxide reductase (msrA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903260 (0.E+01)

<400>   2752
Met Ala Glu Ile Tyr Leu Ala Gly Gly Cys Phe Trp Gly Leu Glu Glu 
1               5                   10                  15      

Tyr Phe Ser Arg Ile Ser Gly Val Leu Glu Thr Ser Val Gly Tyr Ala 
            20                  25                  30          

Asn Gly Gln Val Glu Thr Thr Asn Tyr Gln Leu Leu Lys Glu Thr Asp 
        35                  40                  45              

His Ala Glu Thr Val Gln Val Ile Tyr Asp Glu Lys Glu Val Ser Leu 
    50                  55                  60                  

Arg Glu Ile Leu Leu Tyr Tyr Phe Arg Val Ile Asp Pro Leu Ser Ile 
65                  70                  75                  80  

Asn Gln Gln Gly Asn Asp Arg Gly Arg Gln Tyr Arg Thr Gly Ile Tyr 
                85                  90                  95      

Tyr Gln Asp Glu Ala Asp Leu Pro Ala Ile Tyr Thr Val Val Gln Glu 
            100                 105                 110         

Gln Glu Arg Met Leu Gly Arg Lys Ile Ala Val Glu Val Glu Gln Leu 
        115                 120                 125             

Arg His Tyr Ile Leu Ala Glu Asp Tyr His Gln Asp Tyr Leu Arg Lys 
    130                 135                 140                 

Asn Pro Ser Gly Tyr Cys His Ile Asp Val Thr Asp Ala Asp Lys Pro 
145                 150                 155                 160 

Leu Ile Asp Ala Ala Asn Tyr Glu Lys Pro Ser Gln Glu Val Leu Lys 
                165                 170                 175     

Ala Ser Leu Ser Glu Glu Ser Tyr Arg Val Thr Gln Glu Ala Ala Thr 
            180                 185                 190         

Glu Ala Pro Phe Thr Asn Ala Tyr Asp Gln Thr Phe Glu Glu Gly Ile 
        195                 200                 205             

Tyr Val Asp Ile Thr Thr Gly Glu Pro Leu Phe Phe Ala Lys Asp Lys 
    210                 215                 220                 

Phe Ala Ser Gly Cys Gly Trp Pro Ser Phe Ser Arg Pro Ile Ser Lys 
225                 230                 235                 240 

Glu Leu Ile His Tyr Tyr Lys Asp Leu Ser His Gly Met Glu Arg Ile 
                245                 250                 255     

Glu Val Arg Ser Arg Ser Gly Ser Ala His Leu Gly His Val Phe Thr 
            260                 265                 270         

Asp Gly Pro Arg Glu Leu Gly Gly Leu Arg Tyr Cys Ile Asn Ser Ala 
        275                 280                 285             

Ser Leu Arg Phe Val Ala Lys Asp Glu Met Glu Lys Ala Gly Tyr Gly 
    290                 295                 300                 

Tyr Leu Leu Pro Tyr Leu Asn Lys 
305                 310         

<210>   2753
<211>   210
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2753
atggggaaac tcttgaccag aggggttcat atcctttttg tgaaaagaag tttatactca   60
atgaaaatca aagagcaaac taggaagcta gccgcaggct gctcaaaaca gtgttttgag   120
gttgcagata gaactgacga agtcagctca agacactgtt ttgaggttgc agatagaact   180
gacgaagtca gtaaccatac tacggtaagg                                    210

<210>   2754
<211>   70
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   2754
Met Gly Lys Leu Leu Thr Arg Gly Val His Ile Leu Phe Val Lys Arg 
1               5                   10                  15      

Ser Leu Tyr Ser Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala 
            20                  25                  30          

Gly Cys Ser Lys Gln Cys Phe Glu Val Ala Asp Arg Thr Asp Glu Val 
        35                  40                  45              

Ser Ser Arg His Cys Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser 
    50                  55                  60                  

Asn His Thr Thr Val Arg 
65                  70  

<210>   2755
<211>   867
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2755
atgaagatta ttgtacctgc aaccagtgcc aatatcgggc caggttttga ctcggtcggt   60
gtagctgtaa ccaagtatct tcaaattgag gtctgcgaag aacgagatga gtggctgatt   120
gaacaccaga ttggcaaatg gattccacat gacgagcgta atctcttgct caaaatcgct   180
ttgcaaattg taccagactt gcaaccaaga cgcttgaaaa tgaccagtga tgtccctttg   240
gcgcgcggtt tgggttcttc cagctcggtt atcgttgctg ggattgaact agccaaccaa   300
ctgggtcaac tcaacttatc agaccatgaa aaattgcagt tagcgaccaa gattgaaggg   360
catcctgaca atgtggctcc agccatttat ggtaatctcg ttattgcaag ttctgttgaa   420
gggcaagtct ctgctatcgt agcagacttt ccagagtgtg attttctagc ttacattcca   480
aactatgaat tacgtactcg cgacagccgt agtgtcttgc ctaaaaaatt gtcttataag   540
gaagctgttg ctgcaagttc tatcgccaat gtagcggttg ctgccttgtt ggcaggagac   600
atggtgaccg ctgggcaagc aatcgaggga gacctcttcc atgagcgcta tcgtcaggac   660
ttggtaagag aatttgcgat gattaagcaa gtgaccaaag aaaatggggc ctatgcaacc   720
tacctttctg gtgctgggcc gacagttatg gttctggctt ctcatgacaa gatgccaaca   780
attaaggcag aattggaaaa gcaacctttc aaaggaaaac tgcatgactt gagagttgat   840
acccaaggtg tccgtgtaga agcaaaa                                       867

<210>   2756
<211>   289
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   homoserine kinase (thrB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903261 (e-162)

<400>   2756
Met Lys Ile Ile Val Pro Ala Thr Ser Ala Asn Ile Gly Pro Gly Phe 
1               5                   10                  15      

Asp Ser Val Gly Val Ala Val Thr Lys Tyr Leu Gln Ile Glu Val Cys 
            20                  25                  30          

Glu Glu Arg Asp Glu Trp Leu Ile Glu His Gln Ile Gly Lys Trp Ile 
        35                  40                  45              

Pro His Asp Glu Arg Asn Leu Leu Leu Lys Ile Ala Leu Gln Ile Val 
    50                  55                  60                  

Pro Asp Leu Gln Pro Arg Arg Leu Lys Met Thr Ser Asp Val Pro Leu 
65                  70                  75                  80  

Ala Arg Gly Leu Gly Ser Ser Ser Ser Val Ile Val Ala Gly Ile Glu 
                85                  90                  95      

Leu Ala Asn Gln Leu Gly Gln Leu Asn Leu Ser Asp His Glu Lys Leu 
            100                 105                 110         

Gln Leu Ala Thr Lys Ile Glu Gly His Pro Asp Asn Val Ala Pro Ala 
        115                 120                 125             

Ile Tyr Gly Asn Leu Val Ile Ala Ser Ser Val Glu Gly Gln Val Ser 
    130                 135                 140                 

Ala Ile Val Ala Asp Phe Pro Glu Cys Asp Phe Leu Ala Tyr Ile Pro 
145                 150                 155                 160 

Asn Tyr Glu Leu Arg Thr Arg Asp Ser Arg Ser Val Leu Pro Lys Lys 
                165                 170                 175     

Leu Ser Tyr Lys Glu Ala Val Ala Ala Ser Ser Ile Ala Asn Val Ala 
            180                 185                 190         

Val Ala Ala Leu Leu Ala Gly Asp Met Val Thr Ala Gly Gln Ala Ile 
        195                 200                 205             

Glu Gly Asp Leu Phe His Glu Arg Tyr Arg Gln Asp Leu Val Arg Glu 
    210                 215                 220                 

Phe Ala Met Ile Lys Gln Val Thr Lys Glu Asn Gly Ala Tyr Ala Thr 
225                 230                 235                 240 

Tyr Leu Ser Gly Ala Gly Pro Thr Val Met Val Leu Ala Ser His Asp 
                245                 250                 255     

Lys Met Pro Thr Ile Lys Ala Glu Leu Glu Lys Gln Pro Phe Lys Gly 
            260                 265                 270         

Lys Leu His Asp Leu Arg Val Asp Thr Gln Gly Val Arg Val Glu Ala 
        275                 280                 285             

Lys 
    

<210>   2757
<211>   1317
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2757
atggctatat tagaaaattt cgaggagata aagatgacag ttaaaattgc tttactagga   60
tttggtaccg ttgcaagtgg tgtgcctttc ctcctaaagg aaaatggagg aaaaatcaat   120
caatcagcac attcagatat caaagttgct aaggtattgg tcaaggatga agatgaaaaa   180
aatcgcttgc ttgcagcagg gaatgacttt aactttgtaa ccaatgtgga tgatatttta   240
tcagaccagg atattactat cgtagtggaa ttgatggggc gtattgagcc tgctaaaacc   300
tttatcactc gtgccttgga agctggaaaa cacgttgtta ctgctaacaa ggacctttta   360
gctgtccatg gcgcagaatt gctagaaatc gctcaagcta acaaggtagc actttactac   420
gaagcagcag ttgctggtgg gattccaatt cttcgtactt tagcaaattc cttggcttct   480
gataaaatta cgcgcgtgct tggagtagtc aacggaactt ccaacttcat ggtgaccaag   540
atggtggaag aaggctggtc ttacgatgat gctcttgcgg aagcacaacg tctaggattt   600
gcagaaagcg atccgacgaa tgacgtagat gggattgatg cagcctacaa gatggttatt   660
ttgagccaat ttgcctttgg catgaagatt gcctttgatg atgtagccca caagggaatc   720
cgcaatatca caccagaaga cgtagctgta gctcaagagc ttggttacgt agtgaaattg   780
gttggttcta ttgaggaaac ttcttcaggt attgctgcag aagtgactcc aaccttccta   840
cctaaagcgc acccacttgc tagtgtgaat ggcgtaatga acgctgtctt tgtagaatct   900
atcggtattg gtgagtctat gtactacgga ccaggtgcgg gtcaaaaacc aactgcaaca   960
agtgttgtag ctgatattgt ccgtatcgtt cgtcgtttga atgatggtac tattggcaaa   1020
gacttcaacg aatatagccg tgacttggtc ttggcaaatc ctgaagatgt caaagcaaac   1080
tactatttct caatcttggc tctagactca aaaggtcagg tcttgaagtt ggctgaaatc   1140
ttcaatgctc aagatatttc ctttaagcaa atccttcaag atggcaaaga gggtgacaag   1200
gcgcgtgtcg ttatcatcac acacaagatt aataaagccc agcttgaaaa tgtctcagct   1260
gaattgaaga aggtttcaga attcgacctc ttgaatacct tcaaggtgct aggagaa      1317

<210>   2758
<211>   439
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   homoserine dehydrogenase (hom)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903262 (0.E+01)

<400>   2758
Met Ala Ile Leu Glu Asn Phe Glu Glu Ile Lys Met Thr Val Lys Ile 
1               5                   10                  15      

Ala Leu Leu Gly Phe Gly Thr Val Ala Ser Gly Val Pro Phe Leu Leu 
            20                  25                  30          

Lys Glu Asn Gly Gly Lys Ile Asn Gln Ser Ala His Ser Asp Ile Lys 
        35                  40                  45              

Val Ala Lys Val Leu Val Lys Asp Glu Asp Glu Lys Asn Arg Leu Leu 
    50                  55                  60                  

Ala Ala Gly Asn Asp Phe Asn Phe Val Thr Asn Val Asp Asp Ile Leu 
65                  70                  75                  80  

Ser Asp Gln Asp Ile Thr Ile Val Val Glu Leu Met Gly Arg Ile Glu 
                85                  90                  95      

Pro Ala Lys Thr Phe Ile Thr Arg Ala Leu Glu Ala Gly Lys His Val 
            100                 105                 110         

Val Thr Ala Asn Lys Asp Leu Leu Ala Val His Gly Ala Glu Leu Leu 
        115                 120                 125             

Glu Ile Ala Gln Ala Asn Lys Val Ala Leu Tyr Tyr Glu Ala Ala Val 
    130                 135                 140                 

Ala Gly Gly Ile Pro Ile Leu Arg Thr Leu Ala Asn Ser Leu Ala Ser 
145                 150                 155                 160 

Asp Lys Ile Thr Arg Val Leu Gly Val Val Asn Gly Thr Ser Asn Phe 
                165                 170                 175     

Met Val Thr Lys Met Val Glu Glu Gly Trp Ser Tyr Asp Asp Ala Leu 
            180                 185                 190         

Ala Glu Ala Gln Arg Leu Gly Phe Ala Glu Ser Asp Pro Thr Asn Asp 
        195                 200                 205             

Val Asp Gly Ile Asp Ala Ala Tyr Lys Met Val Ile Leu Ser Gln Phe 
    210                 215                 220                 

Ala Phe Gly Met Lys Ile Ala Phe Asp Asp Val Ala His Lys Gly Ile 
225                 230                 235                 240 

Arg Asn Ile Thr Pro Glu Asp Val Ala Val Ala Gln Glu Leu Gly Tyr 
                245                 250                 255     

Val Val Lys Leu Val Gly Ser Ile Glu Glu Thr Ser Ser Gly Ile Ala 
            260                 265                 270         

Ala Glu Val Thr Pro Thr Phe Leu Pro Lys Ala His Pro Leu Ala Ser 
        275                 280                 285             

Val Asn Gly Val Met Asn Ala Val Phe Val Glu Ser Ile Gly Ile Gly 
    290                 295                 300                 

Glu Ser Met Tyr Tyr Gly Pro Gly Ala Gly Gln Lys Pro Thr Ala Thr 
305                 310                 315                 320 

Ser Val Val Ala Asp Ile Val Arg Ile Val Arg Arg Leu Asn Asp Gly 
                325                 330                 335     

Thr Ile Gly Lys Asp Phe Asn Glu Tyr Ser Arg Asp Leu Val Leu Ala 
            340                 345                 350         

Asn Pro Glu Asp Val Lys Ala Asn Tyr Tyr Phe Ser Ile Leu Ala Leu 
        355                 360                 365             

Asp Ser Lys Gly Gln Val Leu Lys Leu Ala Glu Ile Phe Asn Ala Gln 
    370                 375                 380                 

Asp Ile Ser Phe Lys Gln Ile Leu Gln Asp Gly Lys Glu Gly Asp Lys 
385                 390                 395                 400 

Ala Arg Val Val Ile Ile Thr His Lys Ile Asn Lys Ala Gln Leu Glu 
                405                 410                 415     

Asn Val Ser Ala Glu Leu Lys Lys Val Ser Glu Phe Asp Leu Leu Asn 
            420                 425                 430         

Thr Phe Lys Val Leu Gly Glu 
        435                 

<210>   2759
<211>   750
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2759
atgaggttac tagcaatgaa aatgaaacaa attagtgata caactttaaa aatcacgata   60
tctttagagg atttgatgga tcgtggaatg gagattgctg actttctcgt tcctcaagaa   120
aaaacagaag agttctttta tgctatcttg gatgagctag agatgcctga tagctttctg   180
gatacaggca tgttgagctt ccgtgtgact ccaaaacctg ataaggtaga tgtctttgtg   240
accaagtcaa agattgacca aaatctagat tttgaagact tatcggattt gccagatatg   300
gaagaattgg ctcaaatgtc tccagatgaa tttatcaaaa ccctggaaaa aagcatcgca   360
gacaaaacca aggatgatat cgaagccatt caatctcttg agcaagttga agtcaaggaa   420
gaagagcaag agcaggctga acaagaagct gagagtaaga aagaacctta catctactac   480
atcctttctt ttgctaagtt ggctgacttg gtagcttttg ccaagacagt gacttttgaa   540
atggaaactt ctgaactcta caaaatgaac gagcgctatt atttgaccat tttagtggat   600
attgaaaatc atccaagccc atatccagct tggctgttgg cccgtatgcg cgagtttgca   660
gacgatagtg atatcagtcg ctcagtctta caagagtatg gtcaagtctt gatgagtcac   720
gatgcagtgc tcaatctgca aaaaatcggc                                    750

<210>   2760
<211>   250
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   putative transcriptional regulator MecA (mecA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903263 (e-136)

<400>   2760
Met Arg Leu Leu Ala Met Lys Met Lys Gln Ile Ser Asp Thr Thr Leu 
1               5                   10                  15      

Lys Ile Thr Ile Ser Leu Glu Asp Leu Met Asp Arg Gly Met Glu Ile 
            20                  25                  30          

Ala Asp Phe Leu Val Pro Gln Glu Lys Thr Glu Glu Phe Phe Tyr Ala 
        35                  40                  45              

Ile Leu Asp Glu Leu Glu Met Pro Asp Ser Phe Leu Asp Thr Gly Met 
    50                  55                  60                  

Leu Ser Phe Arg Val Thr Pro Lys Pro Asp Lys Val Asp Val Phe Val 
65                  70                  75                  80  

Thr Lys Ser Lys Ile Asp Gln Asn Leu Asp Phe Glu Asp Leu Ser Asp 
                85                  90                  95      

Leu Pro Asp Met Glu Glu Leu Ala Gln Met Ser Pro Asp Glu Phe Ile 
            100                 105                 110         

Lys Thr Leu Glu Lys Ser Ile Ala Asp Lys Thr Lys Asp Asp Ile Glu 
        115                 120                 125             

Ala Ile Gln Ser Leu Glu Gln Val Glu Val Lys Glu Glu Glu Gln Glu 
    130                 135                 140                 

Gln Ala Glu Gln Glu Ala Glu Ser Lys Lys Glu Pro Tyr Ile Tyr Tyr 
145                 150                 155                 160 

Ile Leu Ser Phe Ala Lys Leu Ala Asp Leu Val Ala Phe Ala Lys Thr 
                165                 170                 175     

Val Thr Phe Glu Met Glu Thr Ser Glu Leu Tyr Lys Met Asn Glu Arg 
            180                 185                 190         

Tyr Tyr Leu Thr Ile Leu Val Asp Ile Glu Asn His Pro Ser Pro Tyr 
        195                 200                 205             

Pro Ala Trp Leu Leu Ala Arg Met Arg Glu Phe Ala Asp Asp Ser Asp 
    210                 215                 220                 

Ile Ser Arg Ser Val Leu Gln Glu Tyr Gly Gln Val Leu Met Ser His 
225                 230                 235                 240 

Asp Ala Val Leu Asn Leu Gln Lys Ile Gly 
                245                 250 

<210>   2761
<211>   1032
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2761
atgtttgaac attattcagt agctgatttg tttgcaaatc tttataaaaa gcgaaaagca   60
aatattttag ctctcatcgc tttatttgct ctcattgctg taccatttac aattaaagca   120
gttaggaata aaaacactgt caaagataca acaagttatt caacttatct tatctataaa   180
atcactcctc caaaagagtc ggacaaaacg attttgaatc atcaaattgg tggttatagt   240
gatttttatg ggaaattgat tgatggtaat ttgaatggag cttatctttt caatgatgta   300
gaacccagtg agttgaaaaa aattgccagt gaattagaca cgacagaaac aaccttgaaa   360
aattcaacga atgactattg gtggaaaaaa ttgaccgtct actatatgat tgacgatgca   420
ggggttggtg tgaaaatttt gacatcaagt aaagatgcca ataacttgtt agagaaaaaa   480
attgatgggt tgattgagaa atttaaacat gcctatgcaa atgtgaaaat tgaaaaactg   540
gaaaccatca actctaaaga attgaacgca aatggtgaaa cagcgcttgg cttaaatgtg   600
aaaaatctga ttcttcgttt agttgttatt ggagtggttt gtgtgatttt ggttgtgatg   660
ggaaatgtgt tagtttatct ctttaatcca acaatcaata gagtaggtga tttttctcag   720
tatcaaattg attttgtaac agagattaca acaattgcta acctagcaga tgttttgtca   780
tacaaaaata ctggacagga attgaccatc gttagctcaa ataaagctat cttagataaa   840
ttgaaacaga gtcaagaagc tttaaaagga atgcattttg tagatttaca ggatgtatca   900
tctcttttgg aaagagatac agtccttctt gttgaagagt acggagtgac tcgttataag   960
aaatttgagc aaagtcttca aattctcaga aacttaaatc gttctatcct cggtgtagca   1020
acctttaaat ta                                                       1032

<210>   2762
<211>   344
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903264 (0.E+01)

<400>   2762
Met Phe Glu His Tyr Ser Val Ala Asp Leu Phe Ala Asn Leu Tyr Lys 
1               5                   10                  15      

Lys Arg Lys Ala Asn Ile Leu Ala Leu Ile Ala Leu Phe Ala Leu Ile 
            20                  25                  30          

Ala Val Pro Phe Thr Ile Lys Ala Val Arg Asn Lys Asn Thr Val Lys 
        35                  40                  45              

Asp Thr Thr Ser Tyr Ser Thr Tyr Leu Ile Tyr Lys Ile Thr Pro Pro 
    50                  55                  60                  

Lys Glu Ser Asp Lys Thr Ile Leu Asn His Gln Ile Gly Gly Tyr Ser 
65                  70                  75                  80  

Asp Phe Tyr Gly Lys Leu Ile Asp Gly Asn Leu Asn Gly Ala Tyr Leu 
                85                  90                  95      

Phe Asn Asp Val Glu Pro Ser Glu Leu Lys Lys Ile Ala Ser Glu Leu 
            100                 105                 110         

Asp Thr Thr Glu Thr Thr Leu Lys Asn Ser Thr Asn Asp Tyr Trp Trp 
        115                 120                 125             

Lys Lys Leu Thr Val Tyr Tyr Met Ile Asp Asp Ala Gly Val Gly Val 
    130                 135                 140                 

Lys Ile Leu Thr Ser Ser Lys Asp Ala Asn Asn Leu Leu Glu Lys Lys 
145                 150                 155                 160 

Ile Asp Gly Leu Ile Glu Lys Phe Lys His Ala Tyr Ala Asn Val Lys 
                165                 170                 175     

Ile Glu Lys Leu Glu Thr Ile Asn Ser Lys Glu Leu Asn Ala Asn Gly 
            180                 185                 190         

Glu Thr Ala Leu Gly Leu Asn Val Lys Asn Leu Ile Leu Arg Leu Val 
        195                 200                 205             

Val Ile Gly Val Val Cys Val Ile Leu Val Val Met Gly Asn Val Leu 
    210                 215                 220                 

Val Tyr Leu Phe Asn Pro Thr Ile Asn Arg Val Gly Asp Phe Ser Gln 
225                 230                 235                 240 

Tyr Gln Ile Asp Phe Val Thr Glu Ile Thr Thr Ile Ala Asn Leu Ala 
                245                 250                 255     

Asp Val Leu Ser Tyr Lys Asn Thr Gly Gln Glu Leu Thr Ile Val Ser 
            260                 265                 270         

Ser Asn Lys Ala Ile Leu Asp Lys Leu Lys Gln Ser Gln Glu Ala Leu 
        275                 280                 285             

Lys Gly Met His Phe Val Asp Leu Gln Asp Val Ser Ser Leu Leu Glu 
    290                 295                 300                 

Arg Asp Thr Val Leu Leu Val Glu Glu Tyr Gly Val Thr Arg Tyr Lys 
305                 310                 315                 320 

Lys Phe Glu Gln Ser Leu Gln Ile Leu Arg Asn Leu Asn Arg Ser Ile 

                325                 330                 335     

Leu Gly Val Ala Thr Phe Lys Leu 
            340                 

<210>   2763
<211>   1431
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2763
gtgattgatg ggaaacgatt attatttagt ttgaccatag tcagttatgc cttgacgcta   60
gtaagtggaa ttgtgtatct gtttaataat aataatgtta gcttactttc tactttattg   120
ttcttgttgg ttagtagctt aattgcttgt tggaatgata tcaagtatta cttaatccat   180
tttattttct atttaaccat ttttgtattt ctggtatcaa gaccgaccat tgattatttt   240
agggatggtg ctttggatac ctatcatcca atagcctatc gttttgcctt tatagttgtc   300
atgatttcga ttctgggctt gaccacagga ggcattctgg ctcgttactt catagctagg   360
aagaaaataa aagtagcaaa tataggaaat tctctaaaag aggtttatat caagcggtta   420
cgctttgtat cactaggagt ttttcttcta acttatcctt tctatttcat tcggttattt   480
gaacggctct tgtatcgttt gcagacttcc tactatgcct actatgcaaa ttttgaaagt   540
aaactgcctt attttaccta cattttgtct acctttacgg tctatgcaat gtgtatgtat   600
ctggcaacca agccaaagaa attgcaggcc acagcagtgc ttgtctcctt tattgcagct   660
aatactattc atttggcaat tgggacacga aatcccttta ttttaagtat tttatttgct   720
tttgtttatt actttatgcg ggagcaaact gaaaaaggaa aatggattgg gtttaaagaa   780
aagttagcga tttttgtagg ttctcctatt ctcatgttag cgatgggagt actcaattat   840
gtacgggata atgtccaagt ttcccataca ggtttctggg atatcttact tgactttatc   900
tataaacaag ggactagttt tggtgttctg gctcgaggtt ttctatttaa cagtagcctc   960
ccttaccgag atttccgtaa ttttactttt ggtcctgttc ttgattattt tgcaaggggg   1020
agtttgggag ccattttcgg aggaaaagcc tttgaacata caaccaatag tgtggaacta   1080
gctattgata gtaatagtta tgcccacaat ctatcctatc ttgtcttgaa caaggaatac   1140
ttgaaagggc atggtatcgg aagtagttat atcatggagt tgtataccga ctatggtatg   1200
attggagtct ttctgcttag tttcttactc ggcgtattat ttatagccat gctgcaagta   1260
gcctatcgct caaggacaat cctatttgct ttatccctac tcatcttgaa taatctattc   1320
tttatgccaa gaagcagctt ttcagaaagt ttcttcaatt tatttacaat gcaattctgg   1380
ggaattgttc ttgtgattat atttgtagca aaaatgctta caaaggaaaa c            1431

<210>   2764
<211>   477
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903265 (0.E+01)

<400>   2764
Met Ile Asp Gly Lys Arg Leu Leu Phe Ser Leu Thr Ile Val Ser Tyr 
1               5                   10                  15      

Ala Leu Thr Leu Val Ser Gly Ile Val Tyr Leu Phe Asn Asn Asn Asn 
            20                  25                  30          

Val Ser Leu Leu Ser Thr Leu Leu Phe Leu Leu Val Ser Ser Leu Ile 
        35                  40                  45              

Ala Cys Trp Asn Asp Ile Lys Tyr Tyr Leu Ile His Phe Ile Phe Tyr 
    50                  55                  60                  

Leu Thr Ile Phe Val Phe Leu Val Ser Arg Pro Thr Ile Asp Tyr Phe 
65                  70                  75                  80  

Arg Asp Gly Ala Leu Asp Thr Tyr His Pro Ile Ala Tyr Arg Phe Ala 
                85                  90                  95      

Phe Ile Val Val Met Ile Ser Ile Leu Gly Leu Thr Thr Gly Gly Ile 
            100                 105                 110         

Leu Ala Arg Tyr Phe Ile Ala Arg Lys Lys Ile Lys Val Ala Asn Ile 
        115                 120                 125             

Gly Asn Ser Leu Lys Glu Val Tyr Ile Lys Arg Leu Arg Phe Val Ser 
    130                 135                 140                 

Leu Gly Val Phe Leu Leu Thr Tyr Pro Phe Tyr Phe Ile Arg Leu Phe 
145                 150                 155                 160 

Glu Arg Leu Leu Tyr Arg Leu Gln Thr Ser Tyr Tyr Ala Tyr Tyr Ala 
                165                 170                 175     

Asn Phe Glu Ser Lys Leu Pro Tyr Phe Thr Tyr Ile Leu Ser Thr Phe 
            180                 185                 190         

Thr Val Tyr Ala Met Cys Met Tyr Leu Ala Thr Lys Pro Lys Lys Leu 
        195                 200                 205             

Gln Ala Thr Ala Val Leu Val Ser Phe Ile Ala Ala Asn Thr Ile His 
    210                 215                 220                 

Leu Ala Ile Gly Thr Arg Asn Pro Phe Ile Leu Ser Ile Leu Phe Ala 
225                 230                 235                 240 

Phe Val Tyr Tyr Phe Met Arg Glu Gln Thr Glu Lys Gly Lys Trp Ile 
                245                 250                 255     

Gly Phe Lys Glu Lys Leu Ala Ile Phe Val Gly Ser Pro Ile Leu Met 
            260                 265                 270         

Leu Ala Met Gly Val Leu Asn Tyr Val Arg Asp Asn Val Gln Val Ser 
        275                 280                 285             

His Thr Gly Phe Trp Asp Ile Leu Leu Asp Phe Ile Tyr Lys Gln Gly 
    290                 295                 300                 

Thr Ser Phe Gly Val Leu Ala Arg Gly Phe Leu Phe Asn Ser Ser Leu 
305                 310                 315                 320 

Pro Tyr Arg Asp Phe Arg Asn Phe Thr Phe Gly Pro Val Leu Asp Tyr 
                325                 330                 335     

Phe Ala Arg Gly Ser Leu Gly Ala Ile Phe Gly Gly Lys Ala Phe Glu 
            340                 345                 350         

His Thr Thr Asn Ser Val Glu Leu Ala Ile Asp Ser Asn Ser Tyr Ala 
        355                 360                 365             

His Asn Leu Ser Tyr Leu Val Leu Asn Lys Glu Tyr Leu Lys Gly His 
    370                 375                 380                 

Gly Ile Gly Ser Ser Tyr Ile Met Glu Leu Tyr Thr Asp Tyr Gly Met 
385                 390                 395                 400 

Ile Gly Val Phe Leu Leu Ser Phe Leu Leu Gly Val Leu Phe Ile Ala 
                405                 410                 415     

Met Leu Gln Val Ala Tyr Arg Ser Arg Thr Ile Leu Phe Ala Leu Ser 
            420                 425                 430         

Leu Leu Ile Leu Asn Asn Leu Phe Phe Met Pro Arg Ser Ser Phe Ser 
        435                 440                 445             

Glu Ser Phe Phe Asn Leu Phe Thr Met Gln Phe Trp Gly Ile Val Leu 
    450                 455                 460                 

Val Ile Ile Phe Val Ala Lys Met Leu Thr Lys Glu Asn 
465                 470                 475         

<210>   2765
<211>   984
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2765
atggaaactg cattaattag tgtgattgtg ccagtctata atgtggcgca gtacctagaa   60
aaatcgatag cttccattca gaagcagacc tatcaaaatc tggaaattat tcttgttgat   120
gatggtgcaa cagatgaaag tggtcgcttg tgtgattcaa tcgctgaaca agatgacagg   180
gtgtcagtgc ttcataaaaa gaacgaagga ttgtcgcaag cacgaaatga tgggatgaag   240
caggctcacg gggattatct gatttttatt gactcagatg attatatcca tccagaaatg   300
attcagagct tatatgagca attagttcaa gaagatgcgg atgtttcgag ctgtggtgtc   360
atgaatgtct atgctaatga tgaaagccca cagtcagcca atcaggatga ctattttgtc   420
tgtgattctc aaacatttct aaaggaatac ctcataggtg aaaaaatacc tgggacgatt   480
tgcaataagc taatcaagag acagattgca actgccctat cctttcctaa ggggttgatt   540
tacgaagatg cctattacca ttttgattta atcaagttgg ccaagaagta tgtggttaat   600
actaaaccct attattacta tttccataga ggggatagta ttacgaccaa accctatgca   660
gagaaggatt tagcctatat tgatatctac caaaagtttt ataatgaagt tgtgaaaaac   720
tatcctgact tgaaagaggt cgcttttttc agattggcct atgcccactt ctttattctg   780
gataagatgt tgctagatga tcagtataaa cagtttgaag cctattctca gattcatcgt   840
tttttaaaag gccatgcctt tgctatttct aggaatccaa ttttccgtaa ggggagaaga   900
attagtgctt tggccctatt cataaatatt tccttatatc gattcttatt actgaaaaat   960
attgaaaaat ctaaaaaatt acat                                          984

<210>   2766
<211>   328
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 2
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903266 (0.E+01)

<400>   2766
Met Glu Thr Ala Leu Ile Ser Val Ile Val Pro Val Tyr Asn Val Ala 
1               5                   10                  15      

Gln Tyr Leu Glu Lys Ser Ile Ala Ser Ile Gln Lys Gln Thr Tyr Gln 
            20                  25                  30          

Asn Leu Glu Ile Ile Leu Val Asp Asp Gly Ala Thr Asp Glu Ser Gly 
        35                  40                  45              

Arg Leu Cys Asp Ser Ile Ala Glu Gln Asp Asp Arg Val Ser Val Leu 
    50                  55                  60                  

His Lys Lys Asn Glu Gly Leu Ser Gln Ala Arg Asn Asp Gly Met Lys 
65                  70                  75                  80  

Gln Ala His Gly Asp Tyr Leu Ile Phe Ile Asp Ser Asp Asp Tyr Ile 
                85                  90                  95      

His Pro Glu Met Ile Gln Ser Leu Tyr Glu Gln Leu Val Gln Glu Asp 
            100                 105                 110         

Ala Asp Val Ser Ser Cys Gly Val Met Asn Val Tyr Ala Asn Asp Glu 
        115                 120                 125             

Ser Pro Gln Ser Ala Asn Gln Asp Asp Tyr Phe Val Cys Asp Ser Gln 
    130                 135                 140                 

Thr Phe Leu Lys Glu Tyr Leu Ile Gly Glu Lys Ile Pro Gly Thr Ile 
145                 150                 155                 160 

Cys Asn Lys Leu Ile Lys Arg Gln Ile Ala Thr Ala Leu Ser Phe Pro 
                165                 170                 175     

Lys Gly Leu Ile Tyr Glu Asp Ala Tyr Tyr His Phe Asp Leu Ile Lys 
            180                 185                 190         

Leu Ala Lys Lys Tyr Val Val Asn Thr Lys Pro Tyr Tyr Tyr Tyr Phe 
        195                 200                 205             

His Arg Gly Asp Ser Ile Thr Thr Lys Pro Tyr Ala Glu Lys Asp Leu 
    210                 215                 220                 

Ala Tyr Ile Asp Ile Tyr Gln Lys Phe Tyr Asn Glu Val Val Lys Asn 
225                 230                 235                 240 

Tyr Pro Asp Leu Lys Glu Val Ala Phe Phe Arg Leu Ala Tyr Ala His 
                245                 250                 255     


Phe Phe Ile Leu Asp Lys Met Leu Leu Asp Asp Gln Tyr Lys Gln Phe 
            260                 265                 270         

Glu Ala Tyr Ser Gln Ile His Arg Phe Leu Lys Gly His Ala Phe Ala 
        275                 280                 285             

Ile Ser Arg Asn Pro Ile Phe Arg Lys Gly Arg Arg Ile Ser Ala Leu 
    290                 295                 300                 

Ala Leu Phe Ile Asn Ile Ser Leu Tyr Arg Phe Leu Leu Leu Lys Asn 
305                 310                 315                 320 

Ile Glu Lys Ser Lys Lys Leu His 
                325             

<210>   2767
<211>   1155
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2767
atgatgctgt catcgctgat atggataagt cttatacaga atacaaggga gaatatggtg   60
gctaagaaaa aaatcttatt ttttatgtgg tctttttctc ttggaggtgg tgcagagaag   120
attctatcaa ccattgtttc aaatctggat ccagaaaagt atgatattga tattcttgaa   180
atggagcact ttgacaaggg atatgaatct gttccaaagc atgtacgcat tttaaaatcc   240
cttcaagatt atcgccaaac cagatggtta cgagcttttt tgtggagaat gagaatttat   300
tttccaagac tgactcgtcg tttgcttgta aaagatgatt atgatgttga agtttctttt   360
accattatga atccaccact gttgttctct aaaagaagag aagtcaagaa gatatcttgg   420
attcatggaa gtattgaaga acttcttaag gatagctcta aaagagaatc acatagaagc   480
cagttggatg ctgcgaatac aattgtaggg atttcaaaaa agaccagcaa ttctatcaag   540
gaagtttatc cagattatac ttctaaatta cagacaatct acaatggata tgattttcag   600
actattctag aaaaatctca agagaagatc gatatcgaga ttgctcctca aagtatctgt   660
actatcggac ggattgagga aaataagggt tctgaccgtg tagtggaagt gatacgatta   720
ttacaccaag agggaaaaaa ctatcatctc tattttatcg gggctggtga tatggaagag   780
gaactgaaaa aacgagtcaa agagtatggg attgaggact atgtacattt ccttggttat   840
caaaaaaatc cttatcagta tctatctcag acgaaagttc ttttgtctat gtctaaacaa   900
gaaggttttc ctggagtgta tgtggaggcc ttgagtctgg gactcccttt tatctctacg   960
gacgttggag gggctgagga attatcccaa gaaggacgat ttggacaaat cattgagagc   1020
aatcaagagg cagctcaggc gattactaat tacatgactt ctgcctcaaa ctttgatgtc   1080
gatgaggcta gccaattcat tcaacaattt acaattacaa aacaaatcga acaagtagaa   1140
aaactattag aggag                                                    1155

<210>   2768
<211>   385
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, group 1
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903267 (0.E+01)

<400>   2768
Met Met Leu Ser Ser Leu Ile Trp Ile Ser Leu Ile Gln Asn Thr Arg 
1               5                   10                  15      

Glu Asn Met Val Ala Lys Lys Lys Ile Leu Phe Phe Met Trp Ser Phe 
            20                  25                  30          

Ser Leu Gly Gly Gly Ala Glu Lys Ile Leu Ser Thr Ile Val Ser Asn 
        35                  40                  45              

Leu Asp Pro Glu Lys Tyr Asp Ile Asp Ile Leu Glu Met Glu His Phe 
    50                  55                  60                  

Asp Lys Gly Tyr Glu Ser Val Pro Lys His Val Arg Ile Leu Lys Ser 
65                  70                  75                  80  

Leu Gln Asp Tyr Arg Gln Thr Arg Trp Leu Arg Ala Phe Leu Trp Arg 
                85                  90                  95      

Met Arg Ile Tyr Phe Pro Arg Leu Thr Arg Arg Leu Leu Val Lys Asp 
            100                 105                 110         

Asp Tyr Asp Val Glu Val Ser Phe Thr Ile Met Asn Pro Pro Leu Leu 
        115                 120                 125             

Phe Ser Lys Arg Arg Glu Val Lys Lys Ile Ser Trp Ile His Gly Ser 
    130                 135                 140                 

Ile Glu Glu Leu Leu Lys Asp Ser Ser Lys Arg Glu Ser His Arg Ser 
145                 150                 155                 160 

Gln Leu Asp Ala Ala Asn Thr Ile Val Gly Ile Ser Lys Lys Thr Ser 
                165                 170                 175     

Asn Ser Ile Lys Glu Val Tyr Pro Asp Tyr Thr Ser Lys Leu Gln Thr 
            180                 185                 190         

Ile Tyr Asn Gly Tyr Asp Phe Gln Thr Ile Leu Glu Lys Ser Gln Glu 
        195                 200                 205             

Lys Ile Asp Ile Glu Ile Ala Pro Gln Ser Ile Cys Thr Ile Gly Arg 
    210                 215                 220                 

Ile Glu Glu Asn Lys Gly Ser Asp Arg Val Val Glu Val Ile Arg Leu 
225                 230                 235                 240 

Leu His Gln Glu Gly Lys Asn Tyr His Leu Tyr Phe Ile Gly Ala Gly 
                245                 250                 255     

Asp Met Glu Glu Glu Leu Lys Lys Arg Val Lys Glu Tyr Gly Ile Glu 
            260                 265                 270         

Asp Tyr Val His Phe Leu Gly Tyr Gln Lys Asn Pro Tyr Gln Tyr Leu 
        275                 280                 285             

Ser Gln Thr Lys Val Leu Leu Ser Met Ser Lys Gln Glu Gly Phe Pro 
    290                 295                 300                 

Gly Val Tyr Val Glu Ala Leu Ser Leu Gly Leu Pro Phe Ile Ser Thr 
305                 310                 315                 320 

Asp Val Gly Gly Ala Glu Glu Leu Ser Gln Glu Gly Arg Phe Gly Gln 
                325                 330                 335     

Ile Ile Glu Ser Asn Gln Glu Ala Ala Gln Ala Ile Thr Asn Tyr Met 
            340                 345                 350         

Thr Ser Ala Ser Asn Phe Asp Val Asp Glu Ala Ser Gln Phe Ile Gln 
        355                 360                 365             

Gln Phe Thr Ile Thr Lys Gln Ile Glu Gln Val Glu Lys Leu Leu Glu 
    370                 375                 380                 

Glu 
385 

<210>   2769
<211>   843
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2769
atgaacaata tgactgattt aaaagcaatt caggctcgta gtctggagat ggctgaatat   60
tttgtggcct tttgtaaaga acatgatttg ctctgttatc tctgtggcgg aggcgctatt   120
ggtgcccttc gaaacaaggg atttattcct tgggacgacg acctagactt ttttatgcct   180
cgtaaagatt atgagaaatt agcagaatta tggcctcgtt atgcagatga acgttatttc   240
ttgtcaaaga gtcacaagga ttttgttgat cgtaatcttt ttattaccat tcgtgacaag   300
aaaaccacct gtatcaagcc ttatcagcag gatttggatt tgccacatgg tctggccttg   360
gatgttttgc ctttggatta ttatccgaaa aatccagctg agcggaaaaa acaggttcgt   420
tgggccttga tttattcact cttttgtgcg caaactattc cagaaaagca tggtgatctc   480
atgaaatggg gaagtcgcat tttactgggt ttgactccaa aatctctccg ttatcgcatc   540
tggaaaaaag ctgagaaaga aatgactaag tatgatttgg ctgattgtga tggcattaca   600
gaattatgct caggtcctgg ctacatgaga aacaagtacc caatcacatc ttttgaagac   660
aatcttttct tgccatttga aggaacagag atgcctattc caatcggcta tgatgtctat   720
ctcagaactg cttttgggga ttatatgacg cctccaccag cagacaagca ggtaccgcat   780
catgatgctg tcatcgctga tatggataag tcttatacag aatacaaggg agaatatggt   840
ggc                                                                 843

<210>   2770
<211>   281
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   licD3 protein (licD3)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903268 (e-172)

<400>   2770
Met Asn Asn Met Thr Asp Leu Lys Ala Ile Gln Ala Arg Ser Leu Glu 
1               5                   10                  15      

Met Ala Glu Tyr Phe Val Ala Phe Cys Lys Glu His Asp Leu Leu Cys 
            20                  25                  30          

Tyr Leu Cys Gly Gly Gly Ala Ile Gly Ala Leu Arg Asn Lys Gly Phe 
        35                  40                  45              

Ile Pro Trp Asp Asp Asp Leu Asp Phe Phe Met Pro Arg Lys Asp Tyr 
    50                  55                  60                  

Glu Lys Leu Ala Glu Leu Trp Pro Arg Tyr Ala Asp Glu Arg Tyr Phe 
65                  70                  75                  80  

Leu Ser Lys Ser His Lys Asp Phe Val Asp Arg Asn Leu Phe Ile Thr 
                85                  90                  95      

Ile Arg Asp Lys Lys Thr Thr Cys Ile Lys Pro Tyr Gln Gln Asp Leu 
            100                 105                 110         

Asp Leu Pro His Gly Leu Ala Leu Asp Val Leu Pro Leu Asp Tyr Tyr 
        115                 120                 125             

Pro Lys Asn Pro Ala Glu Arg Lys Lys Gln Val Arg Trp Ala Leu Ile 
    130                 135                 140                 

Tyr Ser Leu Phe Cys Ala Gln Thr Ile Pro Glu Lys His Gly Asp Leu 
145                 150                 155                 160 

Met Lys Trp Gly Ser Arg Ile Leu Leu Gly Leu Thr Pro Lys Ser Leu 
                165                 170                 175     

Arg Tyr Arg Ile Trp Lys Lys Ala Glu Lys Glu Met Thr Lys Tyr Asp 
            180                 185                 190         

Leu Ala Asp Cys Asp Gly Ile Thr Glu Leu Cys Ser Gly Pro Gly Tyr 
        195                 200                 205             

Met Arg Asn Lys Tyr Pro Ile Thr Ser Phe Glu Asp Asn Leu Phe Leu 
    210                 215                 220                 

Pro Phe Glu Gly Thr Glu Met Pro Ile Pro Ile Gly Tyr Asp Val Tyr 
225                 230                 235                 240 

Leu Arg Thr Ala Phe Gly Asp Tyr Met Thr Pro Pro Pro Ala Asp Lys 
                245                 250                 255     

Gln Val Pro His His Asp Ala Val Ile Ala Asp Met Asp Lys Ser Tyr 
            260                 265                 270         

Thr Glu Tyr Lys Gly Glu Tyr Gly Gly 
        275                 280     

<210>   2771
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2771
gtgaagctga cgtggtttga agagattttc gaagagtata agacagaaaa atcaaagttt   60
gatagctatt tggatagcag tcaggctttg attttttaca gtctgcaa                108

<210>   2772
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   2772
Met Lys Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr Lys Thr Glu 
1               5                   10                  15      

Lys Ser Lys Phe Asp Ser Tyr Leu Asp Ser Ser Gln Ala Leu Ile Phe 
            20                  25                  30          

Tyr Ser Leu Gln 
        35      

<210>   2773
<211>   1272
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2773
atgagtaaag aaaatccctt aagtcatcat gagcagttgc gttatgatta tttgctaaaa   60
aatattcact atctcaatga gagagaaaaa aatgagtttg cctatttgca agaaaagcta   120
actcttgcta ggggaaatag tagctctagc ttggaacaag aaagagaaga gcaggttgac   180
ttaccaagct atgcgaaccg gagtcgctca caatccaaat cacaagcact ctctttccct   240
ccaaaaaaga aaagacggaa gctccgtctt aaacgaattt ttatggtgat tttttcactt   300
ttggtctgtg tggctttggc catggtattc atgtttttgc gtggttacca agatgctagc   360
gcaaagaaaa ctgctgatgc ccgggcagct caagtagaag tctttaatgg tcaggacact   420
agagatggag ttaatatttt aatcatgggt actgatggtc gaatcggcca gaacagtgtt   480
gagacacgaa ctgactctat tatggtatta aatgtcgggg gctcagataa gaaaatgaag   540
ctagtcagtt tcatgcgtga taatttggtc tatatagatg gttatagtca agtgattaat   600
ggtagaaaac agacagataa caagttaaac gtagcctacg agttaggaga acaagagggg   660
caaaaagggg cagaaatggt tcgccaagtc ttgaaagata attttgactt ggacattaag   720
tactacgcct tggttgattt ccaggccttt gccacagcga ttgacacgct tttccctgat   780
ggggtgacga ttgatgctca attttcaaca ttgaatgggc gtcccctaac agaagctaca   840
gtcggagatg atttatacgc taccgagact gagtctccaa cccaaaccat taaagtcgga   900
aaacagcaga tgaatggctc gaccctgctc aattatgctc gtttccgtga tgatgatgag   960
gcagattacg gccgtacaaa aagacagcaa caagttttaa cagcaatttt agagcaaatt   1020
aaagatccca ctaaactttt cactggttct gaagctcttg gaaaggtttt tgctatgacc   1080
tcaaccaacg taccctatac tttcctccta acaaacggtt tatctgtttt ggatggagca   1140
aaaaatggta ttgaaaaatt gacgattcca gaactgggtg actgggtaga tgcctatgat   1200
gtttatgggg gcttgggcct gctggttgat caaaacaaat atcaaaccaa gctcgctcaa   1260
atgggcttaa ga                                                       1272

<210>   2774
<211>   424
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   psr protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903269 (0.E+01)

<400>   2774
Met Ser Lys Glu Asn Pro Leu Ser His His Glu Gln Leu Arg Tyr Asp 
1               5                   10                  15      

Tyr Leu Leu Lys Asn Ile His Tyr Leu Asn Glu Arg Glu Lys Asn Glu 
            20                  25                  30          

Phe Ala Tyr Leu Gln Glu Lys Leu Thr Leu Ala Arg Gly Asn Ser Ser 
        35                  40                  45              

Ser Ser Leu Glu Gln Glu Arg Glu Glu Gln Val Asp Leu Pro Ser Tyr 
    50                  55                  60                  

Ala Asn Arg Ser Arg Ser Gln Ser Lys Ser Gln Ala Leu Ser Phe Pro 
65                  70                  75                  80  

Pro Lys Lys Lys Arg Arg Lys Leu Arg Leu Lys Arg Ile Phe Met Val 
                85                  90                  95      

Ile Phe Ser Leu Leu Val Cys Val Ala Leu Ala Met Val Phe Met Phe 
            100                 105                 110         

Leu Arg Gly Tyr Gln Asp Ala Ser Ala Lys Lys Thr Ala Asp Ala Arg 
        115                 120                 125             

Ala Ala Gln Val Glu Val Phe Asn Gly Gln Asp Thr Arg Asp Gly Val 
    130                 135                 140                 

Asn Ile Leu Ile Met Gly Thr Asp Gly Arg Ile Gly Gln Asn Ser Val 
145                 150                 155                 160 

Glu Thr Arg Thr Asp Ser Ile Met Val Leu Asn Val Gly Gly Ser Asp 
                165                 170                 175     

Lys Lys Met Lys Leu Val Ser Phe Met Arg Asp Asn Leu Val Tyr Ile 
            180                 185                 190         

Asp Gly Tyr Ser Gln Val Ile Asn Gly Arg Lys Gln Thr Asp Asn Lys 
        195                 200                 205             

Leu Asn Val Ala Tyr Glu Leu Gly Glu Gln Glu Gly Gln Lys Gly Ala 
    210                 215                 220                 

Glu Met Val Arg Gln Val Leu Lys Asp Asn Phe Asp Leu Asp Ile Lys 
225                 230                 235                 240 

Tyr Tyr Ala Leu Val Asp Phe Gln Ala Phe Ala Thr Ala Ile Asp Thr 
                245                 250                 255     

Leu Phe Pro Asp Gly Val Thr Ile Asp Ala Gln Phe Ser Thr Leu Asn 
            260                 265                 270         

Gly Arg Pro Leu Thr Glu Ala Thr Val Gly Asp Asp Leu Tyr Ala Thr 
        275                 280                 285             

Glu Thr Glu Ser Pro Thr Gln Thr Ile Lys Val Gly Lys Gln Gln Met 
    290                 295                 300                 

Asn Gly Ser Thr Leu Leu Asn Tyr Ala Arg Phe Arg Asp Asp Asp Glu 
305                 310                 315                 320 

Ala Asp Tyr Gly Arg Thr Lys Arg Gln Gln Gln Val Leu Thr Ala Ile 
                325                 330                 335     

Leu Glu Gln Ile Lys Asp Pro Thr Lys Leu Phe Thr Gly Ser Glu Ala 
            340                 345                 350         

Leu Gly Lys Val Phe Ala Met Thr Ser Thr Asn Val Pro Tyr Thr Phe 
        355                 360                 365             

Leu Leu Thr Asn Gly Leu Ser Val Leu Asp Gly Ala Lys Asn Gly Ile 
    370                 375                 380                 

Glu Lys Leu Thr Ile Pro Glu Leu Gly Asp Trp Val Asp Ala Tyr Asp 
385                 390                 395                 400 

Val Tyr Gly Gly Leu Gly Leu Leu Val Asp Gln Asn Lys Tyr Gln Thr 
                405                 410                 415     

Lys Leu Ala Gln Met Gly Leu Arg 
            420                 

<210>   2775
<211>   846
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2775
atgaaaattg cttatctagg tcccaaggga tcattttcac accacgttgt gcagacagct   60
tttcctcatg aggaattgca ggcttttgcc aacattacag atgtcatcaa ggcttatgag   120
caaggattag tgaactattc tgtggtgcca gttgaaaatt ctattgaggg tagtgttcat   180
gaaaccttgg actatctttt tcatcaggct cacatccaag cagtagcaga aatcgttcag   240
cctattcatc agcagttgat ggtggttcca ggccatacta agattgaaaa gattttttca   300
catccacagg ccttggctca aggaaagaaa ttcatcgatg aacaatatcc agaggctcaa   360
atcgaggtaa cagctagtac agcttatgcg gcccgtttta tttccgaaca tccagaccag   420
ccctttgcag cagttgcacc tagaagttct gctgaagaat atggattgga actgattgcc   480
gaggatattc aggaaatgga agccaatttc acacgtttct gggttctagg agctgaaaag   540
cctagtattc ccttgcaagc acaaactgaa aagatgagtt tggccttgac attacctgac   600
aaccttccag gtgcacttta taaggccctg tcgacctttg cttggcgagg aattgacttg   660
acaaaaattg aaagttgtcc actcaagaca gcactgggtg aatacttttt cattatcgat   720
gtggattata ccgataagga cttggtccac tttgcccaaa aagaattaga agcgattgga   780
atccagtata aaattctggg tgcctatcct atttatccaa tatcagacca tggaaaggag   840
agaaga                                                              846

<210>   2776
<211>   282
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   prephenate dehydratase (pheA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903270 (e-161)

<400>   2776
Met Lys Ile Ala Tyr Leu Gly Pro Lys Gly Ser Phe Ser His His Val 
1               5                   10                  15      

Val Gln Thr Ala Phe Pro His Glu Glu Leu Gln Ala Phe Ala Asn Ile 
            20                  25                  30          

Thr Asp Val Ile Lys Ala Tyr Glu Gln Gly Leu Val Asn Tyr Ser Val 
        35                  40                  45              

Val Pro Val Glu Asn Ser Ile Glu Gly Ser Val His Glu Thr Leu Asp 
    50                  55                  60                  

Tyr Leu Phe His Gln Ala His Ile Gln Ala Val Ala Glu Ile Val Gln 
65                  70                  75                  80  

Pro Ile His Gln Gln Leu Met Val Val Pro Gly His Thr Lys Ile Glu 
                85                  90                  95      

Lys Ile Phe Ser His Pro Gln Ala Leu Ala Gln Gly Lys Lys Phe Ile 
            100                 105                 110         

Asp Glu Gln Tyr Pro Glu Ala Gln Ile Glu Val Thr Ala Ser Thr Ala 
        115                 120                 125             

Tyr Ala Ala Arg Phe Ile Ser Glu His Pro Asp Gln Pro Phe Ala Ala 
    130                 135                 140                 

Val Ala Pro Arg Ser Ser Ala Glu Glu Tyr Gly Leu Glu Leu Ile Ala 
145                 150                 155                 160 

Glu Asp Ile Gln Glu Met Glu Ala Asn Phe Thr Arg Phe Trp Val Leu 
                165                 170                 175     

Gly Ala Glu Lys Pro Ser Ile Pro Leu Gln Ala Gln Thr Glu Lys Met 
            180                 185                 190         


Ser Leu Ala Leu Thr Leu Pro Asp Asn Leu Pro Gly Ala Leu Tyr Lys 
        195                 200                 205             

Ala Leu Ser Thr Phe Ala Trp Arg Gly Ile Asp Leu Thr Lys Ile Glu 
    210                 215                 220                 

Ser Cys Pro Leu Lys Thr Ala Leu Gly Glu Tyr Phe Phe Ile Ile Asp 
225                 230                 235                 240 

Val Asp Tyr Thr Asp Lys Asp Leu Val His Phe Ala Gln Lys Glu Leu 
                245                 250                 255     

Glu Ala Ile Gly Ile Gln Tyr Lys Ile Leu Gly Ala Tyr Pro Ile Tyr 
            260                 265                 270         

Pro Ile Ser Asp His Gly Lys Glu Arg Arg 
        275                 280         

<210>   2777
<211>   474
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2777
atggctaagg tgttattagg gtttatgggg gctggaaaat cgactattgc aagaggcttg   60
gaccctaatt accttgatat ggatgctctg attgagaatc gcctaggtat gtccattgcg   120
aattttttcg ctgaaaaggg agaaacagcc tttcgtcagg tagaatcaga agtcctagct   180
gatttactac aaacagacca agtcgtgtca actggaggag gagtggttat ttctcagaga   240
aatcgtgact tactcaagac taatacagat aacatctacc tgagagcaga ttttgaaacc   300
ctctaccaac gtatcgcagc tgataaggac aatcagcgac cgctttttct aaataatagc   360
aaggaagaac tagtagctat tttccaagaa agacaggctt ggtatgagga agtggctagt   420
cgggttttgg atgtgaccaa gctaagccca gaggaaatta tagaggaact aaga         474

<210>   2778
<211>   158
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   shikimate kinase (aroK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903271 (2.E-82)

<400>   2778
Met Ala Lys Val Leu Leu Gly Phe Met Gly Ala Gly Lys Ser Thr Ile 
1               5                   10                  15      

Ala Arg Gly Leu Asp Pro Asn Tyr Leu Asp Met Asp Ala Leu Ile Glu 
            20                  25                  30          

Asn Arg Leu Gly Met Ser Ile Ala Asn Phe Phe Ala Glu Lys Gly Glu 
        35                  40                  45              

Thr Ala Phe Arg Gln Val Glu Ser Glu Val Leu Ala Asp Leu Leu Gln 
    50                  55                  60                  

Thr Asp Gln Val Val Ser Thr Gly Gly Gly Val Val Ile Ser Gln Arg 
65                  70                  75                  80  

Asn Arg Asp Leu Leu Lys Thr Asn Thr Asp Asn Ile Tyr Leu Arg Ala 
                85                  90                  95      

Asp Phe Glu Thr Leu Tyr Gln Arg Ile Ala Ala Asp Lys Asp Asn Gln 
            100                 105                 110         

Arg Pro Leu Phe Leu Asn Asn Ser Lys Glu Glu Leu Val Ala Ile Phe 
        115                 120                 125             

Gln Glu Arg Gln Ala Trp Tyr Glu Glu Val Ala Ser Arg Val Leu Asp 
    130                 135                 140                 

Val Thr Lys Leu Ser Pro Glu Glu Ile Ile Glu Glu Leu Arg 
145                 150                 155             

<210>   2779
<211>   1281
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2779
atgaaactaa aaacaaacat tcgccattta catggtagta tccgcgtccc aggtgacaag   60
tctatcagcc accgttccat tatctttgga agtttggctg agggtgagac caaggtttat   120
gatattctgc gaggtgaaga cgttctttcg accatgcagg tttttcgtga ccttggtgtt   180
gaaattgagg ataaagatgg ggttattacc attcaaggtg taggcatggc tggcttaaaa   240
gcgccacaaa atgcccttaa tatgggaaat tctggcacct cgattcgcct gatttcaggt   300
gtccttgctg gtgcagattt cgaagtagag atgtttggag atgatagtct ttccaaacgt   360
cctatggacc gtgtgaccct tccactgaaa aaaatgggcg tcagcatttc agggcaaact   420
gaacgagact tgcctcccct tcgcttaaaa gggacgaaaa acctaagacc tattcattat   480
gagttgccaa ttgcctctgc ccaagtcaag tcagccttga tgtttgcagc cttacaagct   540
aagggggagt cagttattat cgaaaaagag tacacccgta atcatactga agatatgttg   600
aaacaatttg gtggtcattt aagtgtggat ggtaagaaaa tcacagtcca ggggccacaa   660
aaattgacag gacagaaggt ggtcgtacca ggagatattt ccagtgcagc cttttggtta   720
gtcgcaggtt tgattgctcc aaattctcgt ctagtgctgc agaatgtggg gatcaacgaa   780
actcgcaccg gtattattga tgtcattcgt gccatgggtg gaaaattgga aataactgaa   840
atcgatccag tcgctaaatc tgctaccttg attgttgagt cttctgactt gaaaggaaca   900
gagattggtg gcgctttgat tccacgattg attgatgaat tgcccattat tgccctgctt   960
gcgacccaag cccaaggtgt aacagttatc aaggatgctg aggagctcaa ggtcaaggaa   1020
acagaccgta ttcaggttgt ggcagacgcc ttaaatagta tgggagcaga tattactcct   1080
acggcagatg ggatgattat caaaggaaaa tcagctcttc acggtgctag agtcaatacg   1140
tttggtgacc accgtatcgg catgatgaca gctatcgcag ccctcttggt tgcagatgga   1200
gaggtggagc ttgaccgtgc agaagccatc aataccagct atcctagttt ctttgatgat   1260
ttggagagct tgattcatgg c                                             1281

<210>   2780
<211>   427
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-phosphoshikimate 1-carboxyvinyltransferase (aroA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903272 (0.E+01)

<400>   2780
Met Lys Leu Lys Thr Asn Ile Arg His Leu His Gly Ser Ile Arg Val 
1               5                   10                  15      

Pro Gly Asp Lys Ser Ile Ser His Arg Ser Ile Ile Phe Gly Ser Leu 
            20                  25                  30          

Ala Glu Gly Glu Thr Lys Val Tyr Asp Ile Leu Arg Gly Glu Asp Val 
        35                  40                  45              

Leu Ser Thr Met Gln Val Phe Arg Asp Leu Gly Val Glu Ile Glu Asp 
    50                  55                  60                  

Lys Asp Gly Val Ile Thr Ile Gln Gly Val Gly Met Ala Gly Leu Lys 
65                  70                  75                  80  

Ala Pro Gln Asn Ala Leu Asn Met Gly Asn Ser Gly Thr Ser Ile Arg 
                85                  90                  95      

Leu Ile Ser Gly Val Leu Ala Gly Ala Asp Phe Glu Val Glu Met Phe 
            100                 105                 110         

Gly Asp Asp Ser Leu Ser Lys Arg Pro Met Asp Arg Val Thr Leu Pro 
        115                 120                 125             

Leu Lys Lys Met Gly Val Ser Ile Ser Gly Gln Thr Glu Arg Asp Leu 
    130                 135                 140                 

Pro Pro Leu Arg Leu Lys Gly Thr Lys Asn Leu Arg Pro Ile His Tyr 
145                 150                 155                 160 

Glu Leu Pro Ile Ala Ser Ala Gln Val Lys Ser Ala Leu Met Phe Ala 
                165                 170                 175     

Ala Leu Gln Ala Lys Gly Glu Ser Val Ile Ile Glu Lys Glu Tyr Thr 
            180                 185                 190         

Arg Asn His Thr Glu Asp Met Leu Lys Gln Phe Gly Gly His Leu Ser 
        195                 200                 205             

Val Asp Gly Lys Lys Ile Thr Val Gln Gly Pro Gln Lys Leu Thr Gly 
    210                 215                 220                 

Gln Lys Val Val Val Pro Gly Asp Ile Ser Ser Ala Ala Phe Trp Leu 
225                 230                 235                 240 

Val Ala Gly Leu Ile Ala Pro Asn Ser Arg Leu Val Leu Gln Asn Val 
                245                 250                 255     

Gly Ile Asn Glu Thr Arg Thr Gly Ile Ile Asp Val Ile Arg Ala Met 
            260                 265                 270         

Gly Gly Lys Leu Glu Ile Thr Glu Ile Asp Pro Val Ala Lys Ser Ala 
        275                 280                 285             

Thr Leu Ile Val Glu Ser Ser Asp Leu Lys Gly Thr Glu Ile Gly Gly 
    290                 295                 300                 

Ala Leu Ile Pro Arg Leu Ile Asp Glu Leu Pro Ile Ile Ala Leu Leu 
305                 310                 315                 320 

Ala Thr Gln Ala Gln Gly Val Thr Val Ile Lys Asp Ala Glu Glu Leu 
                325                 330                 335     

Lys Val Lys Glu Thr Asp Arg Ile Gln Val Val Ala Asp Ala Leu Asn 
            340                 345                 350         

Ser Met Gly Ala Asp Ile Thr Pro Thr Ala Asp Gly Met Ile Ile Lys 
        355                 360                 365             

Gly Lys Ser Ala Leu His Gly Ala Arg Val Asn Thr Phe Gly Asp His 
    370                 375                 380                 

Arg Ile Gly Met Met Thr Ala Ile Ala Ala Leu Leu Val Ala Asp Gly 
385                 390                 395                 400 

Glu Val Glu Leu Asp Arg Ala Glu Ala Ile Asn Thr Ser Tyr Pro Ser 
                405                 410                 415     

Phe Phe Asp Asp Leu Glu Ser Leu Ile His Gly 
            420                 425         

<210>   2781
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2781
atgtcaaata tttacgatag tgcaaacgaa ctcagtcgcg gtctacgcgg attaccagaa   60
tacaaggctg ttaaagcagc taaagatgcg attgcagcag atgctgaggc aagcaaaatc   120
tttacagatt atcttgcctt tcaagaggaa attcaaaaac tagcacagac aggtcaaatg   180
ccagatgcgt ccttccaagc taagatggaa ggctttggta aacagattca aggaaatagc   240
ctcttgtcag aattctttac caagcaacaa caattggcca tttacctttc tgatattgaa   300
aaaattgttt ttgaaccagt ttcagaattg ctgaaa                             336

<210>   2782
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903273 (5.E-58)

<400>   2782
Met Ser Asn Ile Tyr Asp Ser Ala Asn Glu Leu Ser Arg Gly Leu Arg 
1               5                   10                  15      

Gly Leu Pro Glu Tyr Lys Ala Val Lys Ala Ala Lys Asp Ala Ile Ala 
            20                  25                  30          

Ala Asp Ala Glu Ala Ser Lys Ile Phe Thr Asp Tyr Leu Ala Phe Gln 
        35                  40                  45              

Glu Glu Ile Gln Lys Leu Ala Gln Thr Gly Gln Met Pro Asp Ala Ser 
    50                  55                  60                  

Phe Gln Ala Lys Met Glu Gly Phe Gly Lys Gln Ile Gln Gly Asn Ser 
65                  70                  75                  80  

Leu Leu Ser Glu Phe Phe Thr Lys Gln Gln Gln Leu Ala Ile Tyr Leu 
                85                  90                  95      

Ser Asp Ile Glu Lys Ile Val Phe Glu Pro Val Ser Glu Leu Leu Lys 
            100                 105                 110         


<210>   2783
<211>   1101
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2783
atggcaaaaa caatctatat cgcaggtctt gggttgattg gagcctctat ggcacttggt   60
atcaaacgcg atcatccaga ttatgaaatt ttaggttata atcgtagtca agcttcgaga   120
gatatcgcct tgaaagaagg tatgattgac cgtgcaacgg atgattttgc tagttttgct   180
cctttggcag atgtcattat cctcagcttg ccaatcaaac aaactattgc tttcattaag   240
gagttggcca atttggattt gcgagaaggc gttattattt cagatgctgg ttcgaccaag   300
tcaaccattg tggatgcggc ggagcagtat ttggctggca agtctgttcg ctttgtcggg   360
gcccatccca tggctggtag tcacaagaca ggggctgctt cggcagatgt caatcttttt   420
gaaaatgcct attatatctt tacaccttca agcctgacaa gtcaggacac gcttaaggaa   480
atgaaggatc tgctttcagg tcttcatgct cgttttatcg agattgatgc caaggagcat   540
gatcgtgtca cttctcagat tagccatttt cctcatattt tggcttctag tctcatggag   600
cagactgcgg tctatgctca agagcatgag atggcaaggc gctttgcggc aggtggtttt   660
cgagatatga cccgaattgc ggaaagcgag ccaggaatgt ggacctccat tctcttgtcc   720
aatagcgaga tcattctgga tagaattgag gatttcaagg aacgtttgga agcgattggt   780
caggccatta gtaagggaga tgaagagcaa atttggaact tttttaacca agcgcgtgaa   840
caacgccaga ccatggaaat ccataagcgt ggtggtgtgg atagctctta cgacctctat   900
gttgacgttc ctgatgaaga agatgtcatc ctgcggattt tggaactgct acgtggaact   960
tccttggtta atatccacat caacgaggaa aatcgtgagg atattcacgg aatcctacaa   1020
atttcattta aaaatgctca agacttggaa agagctgagc atctcataac agaaaatact   1080
gactatacag tcgtcatcaa a                                             1101

<210>   2784
<211>   367
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   prephenate dehydrogenase (tyrA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903274 (0.E+01)

<400>   2784
Met Ala Lys Thr Ile Tyr Ile Ala Gly Leu Gly Leu Ile Gly Ala Ser 
1               5                   10                  15      

Met Ala Leu Gly Ile Lys Arg Asp His Pro Asp Tyr Glu Ile Leu Gly 
            20                  25                  30          

Tyr Asn Arg Ser Gln Ala Ser Arg Asp Ile Ala Leu Lys Glu Gly Met 
        35                  40                  45              

Ile Asp Arg Ala Thr Asp Asp Phe Ala Ser Phe Ala Pro Leu Ala Asp 
    50                  55                  60                  

Val Ile Ile Leu Ser Leu Pro Ile Lys Gln Thr Ile Ala Phe Ile Lys 
65                  70                  75                  80  

Glu Leu Ala Asn Leu Asp Leu Arg Glu Gly Val Ile Ile Ser Asp Ala 
                85                  90                  95      

Gly Ser Thr Lys Ser Thr Ile Val Asp Ala Ala Glu Gln Tyr Leu Ala 
            100                 105                 110         

Gly Lys Ser Val Arg Phe Val Gly Ala His Pro Met Ala Gly Ser His 
        115                 120                 125             

Lys Thr Gly Ala Ala Ser Ala Asp Val Asn Leu Phe Glu Asn Ala Tyr 
    130                 135                 140                 

Tyr Ile Phe Thr Pro Ser Ser Leu Thr Ser Gln Asp Thr Leu Lys Glu 
145                 150                 155                 160 

Met Lys Asp Leu Leu Ser Gly Leu His Ala Arg Phe Ile Glu Ile Asp 
                165                 170                 175     

Ala Lys Glu His Asp Arg Val Thr Ser Gln Ile Ser His Phe Pro His 
            180                 185                 190         

Ile Leu Ala Ser Ser Leu Met Glu Gln Thr Ala Val Tyr Ala Gln Glu 
        195                 200                 205             

His Glu Met Ala Arg Arg Phe Ala Ala Gly Gly Phe Arg Asp Met Thr 
    210                 215                 220                 

Arg Ile Ala Glu Ser Glu Pro Gly Met Trp Thr Ser Ile Leu Leu Ser 
225                 230                 235                 240 

Asn Ser Glu Ile Ile Leu Asp Arg Ile Glu Asp Phe Lys Glu Arg Leu 
                245                 250                 255     

Glu Ala Ile Gly Gln Ala Ile Ser Lys Gly Asp Glu Glu Gln Ile Trp 
            260                 265                 270         

Asn Phe Phe Asn Gln Ala Arg Glu Gln Arg Gln Thr Met Glu Ile His 
        275                 280                 285             

Lys Arg Gly Gly Val Asp Ser Ser Tyr Asp Leu Tyr Val Asp Val Pro 
    290                 295                 300                 

Asp Glu Glu Asp Val Ile Leu Arg Ile Leu Glu Leu Leu Arg Gly Thr 
305                 310                 315                 320 

Ser Leu Val Asn Ile His Ile Asn Glu Glu Asn Arg Glu Asp Ile His 
                325                 330                 335     

Gly Ile Leu Gln Ile Ser Phe Lys Asn Ala Gln Asp Leu Glu Arg Ala 
            340                 345                 350         

Glu His Leu Ile Thr Glu Asn Thr Asp Tyr Thr Val Val Ile Lys 
        355                 360                 365         

<210>   2785
<211>   1164
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2785
atgagatatt taactgcagg agaatcacac ggcccccgtc taacagctat tattgaggga   60
attccagctg gacttccatt gacagctgag gatatcaatg aggaccttag acgccgtcag   120
ggtggctacg gtcgtggtgg tcgtatgaag attgagaatg accaggttgt ctttacttcg   180
ggcgttcgcc acgggaagac gacaggggcg cctattacta tggatgtcat caataaggac   240
caccagaaat ggctggacat catgtctgcg gaggacattg aagaccgcct taaaagcaag   300
cggaaaatta ctcatcctcg cccaggtcat gccgatttgg ttggggggat taagtaccgt   360
tttgatgatt tgcgaaattc tttggagcgt tcatcagctc gtgaaaccac catgcgggtg   420
gcagttggtg cagtagccaa acgcctcttg gctgagctgg atatggagat tgccaaccat   480
gtcgtggtct ttggtggcaa ggaaatcgat gttcctgaaa atctgacagt cgctgaaatt   540
aagcaaagag ctgcccagtc tgaagtttct attgtcaacc aagaacgaga acaggaaatc   600
aaggactata ttgaccaaat caaacgtgat ggtgatacca tcggtggggt tgtggagaca   660
gtcgtcggag gcgttccagt tggtcttggt tcctatgtcc aatgggatag aaaattggat   720
gcaagattgg ctcaagctgt tgtctctatc aatgccttta aaggggtgga atttggtctt   780
ggctttgagg ctggttatcg taaaggcagc caagttatgg atgaaattct ctggtctaaa   840
gaagacggtt atactcgccg taccaataat ctaggtggtt ttgaaggtgg tatgactaat   900
gggcaaccca tcgttgttcg tggggtcatg aaacccattc ctactcttta taaacctctt   960
atgagtgtgg atatcgaaac ccacgaacct tacaaggcaa ccgtggagag aagtgatccg   1020
actgctcttc cagctgcagg aatggtcatg gaagcagttg tagcaacggt tctggcgcaa   1080
gaaatcctcg aaaaattctc atcagataat cttgaggaac taaaagaagc ggtagccaaa   1140
caccgagact atacaaagaa ctat                                          1164

<210>   2786
<211>   388
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   chorismate synthase (aroC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903275 (0.E+01)

<400>   2786
Met Arg Tyr Leu Thr Ala Gly Glu Ser His Gly Pro Arg Leu Thr Ala 
1               5                   10                  15      

Ile Ile Glu Gly Ile Pro Ala Gly Leu Pro Leu Thr Ala Glu Asp Ile 
            20                  25                  30          

Asn Glu Asp Leu Arg Arg Arg Gln Gly Gly Tyr Gly Arg Gly Gly Arg 
        35                  40                  45              

Met Lys Ile Glu Asn Asp Gln Val Val Phe Thr Ser Gly Val Arg His 
    50                  55                  60                  

Gly Lys Thr Thr Gly Ala Pro Ile Thr Met Asp Val Ile Asn Lys Asp 
65                  70                  75                  80  

His Gln Lys Trp Leu Asp Ile Met Ser Ala Glu Asp Ile Glu Asp Arg 
                85                  90                  95      

Leu Lys Ser Lys Arg Lys Ile Thr His Pro Arg Pro Gly His Ala Asp 
            100                 105                 110         

Leu Val Gly Gly Ile Lys Tyr Arg Phe Asp Asp Leu Arg Asn Ser Leu 
        115                 120                 125             

Glu Arg Ser Ser Ala Arg Glu Thr Thr Met Arg Val Ala Val Gly Ala 
    130                 135                 140                 

Val Ala Lys Arg Leu Leu Ala Glu Leu Asp Met Glu Ile Ala Asn His 
145                 150                 155                 160 


Val Val Val Phe Gly Gly Lys Glu Ile Asp Val Pro Glu Asn Leu Thr 
                165                 170                 175     

Val Ala Glu Ile Lys Gln Arg Ala Ala Gln Ser Glu Val Ser Ile Val 
            180                 185                 190         

Asn Gln Glu Arg Glu Gln Glu Ile Lys Asp Tyr Ile Asp Gln Ile Lys 
        195                 200                 205             

Arg Asp Gly Asp Thr Ile Gly Gly Val Val Glu Thr Val Val Gly Gly 
    210                 215                 220                 

Val Pro Val Gly Leu Gly Ser Tyr Val Gln Trp Asp Arg Lys Leu Asp 
225                 230                 235                 240 

Ala Arg Leu Ala Gln Ala Val Val Ser Ile Asn Ala Phe Lys Gly Val 
                245                 250                 255     

Glu Phe Gly Leu Gly Phe Glu Ala Gly Tyr Arg Lys Gly Ser Gln Val 
            260                 265                 270         

Met Asp Glu Ile Leu Trp Ser Lys Glu Asp Gly Tyr Thr Arg Arg Thr 
        275                 280                 285             

Asn Asn Leu Gly Gly Phe Glu Gly Gly Met Thr Asn Gly Gln Pro Ile 
    290                 295                 300                 

Val Val Arg Gly Val Met Lys Pro Ile Pro Thr Leu Tyr Lys Pro Leu 
305                 310                 315                 320 

Met Ser Val Asp Ile Glu Thr His Glu Pro Tyr Lys Ala Thr Val Glu 
                325                 330                 335     

Arg Ser Asp Pro Thr Ala Leu Pro Ala Ala Gly Met Val Met Glu Ala 
            340                 345                 350         

Val Val Ala Thr Val Leu Ala Gln Glu Ile Leu Glu Lys Phe Ser Ser 
        355                 360                 365             

Asp Asn Leu Glu Glu Leu Lys Glu Ala Val Ala Lys His Arg Asp Tyr 
    370                 375                 380                 

Thr Lys Asn Tyr 
385             

<210>   2787
<211>   1065
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2787
atgaaaatca gaatcgatat tcctcaccat ccttatgata ttcagattga aaaaggttgt   60
atggcccagg ctggtcagtg gttgcgagaa ctctggcaac cgcaaaaggt agtcattgtg   120
acagataacc atgtagcctc tctctatgca gagaaggtca agctcagcct agaagatgct   180
ggttttcagg tagctgtttt tgatttctta gaaggtgaag aaagaaagaa tttaactact   240
gttcagaaag tctatgaatt tctagtcaag caaggtctga ctcgtagcga tggaatcgtt   300
gctcttggtg gtggcgttgt tggggacctg gctggatttg tagcctctac ctatatgcgg   360
ggtattcact ttgttcagat tccgactagt ttgacagctc aggttgattc ttctatcggt   420
ggaaagacag gcgttaatac accatttgct aaaaatatgg tggggacctt tgcccaacca   480
gatggggttc tgattgatcc acttgttctt gaaaccctcg gaaaaagaga gttgattgaa   540
gggatgggtg aagttatcaa gtatggcttg attgaggatc cagaactgtg ggctctcttg   600
acgggactga atggttctgt tgagagtatt ttggaacatg cagagacctt gattgaacat   660
tcttgtcagg tgaagcgcaa gatggtggtt gaagatgagt tggacaatgg tattcgtctt   720
tacctcaatt ttggccacac tattggccat gccatcgaag cgactgccgg ttatggcaag   780
gtcatgcatg gagaggctgt tgccatggga atggtacaga tttccaaggt tgctgaggaa   840
aaaggcctca tgccagctgg cattacccaa tctatcacag agatgtgtca gaaattcggt   900
ttgcctgttg actatgaaaa ttgggaagtt ggcaagcttt atcaggctct tactcatgac   960
aagaaagcgc gtggtaacac cttgaaattg gtcttggtgc cagagcttgg ttcagcgacc   1020
attcacccag tttctctgga agagatgaaa gactacttgg taaaa                   1065

<210>   2788
<211>   355
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-dehydroquinate synthase (aroB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903276 (0.E+01)

<400>   2788
Met Lys Ile Arg Ile Asp Ile Pro His His Pro Tyr Asp Ile Gln Ile 
1               5                   10                  15      

Glu Lys Gly Cys Met Ala Gln Ala Gly Gln Trp Leu Arg Glu Leu Trp 
            20                  25                  30          

Gln Pro Gln Lys Val Val Ile Val Thr Asp Asn His Val Ala Ser Leu 
        35                  40                  45              

Tyr Ala Glu Lys Val Lys Leu Ser Leu Glu Asp Ala Gly Phe Gln Val 
    50                  55                  60                  

Ala Val Phe Asp Phe Leu Glu Gly Glu Glu Arg Lys Asn Leu Thr Thr 
65                  70                  75                  80  

Val Gln Lys Val Tyr Glu Phe Leu Val Lys Gln Gly Leu Thr Arg Ser 
                85                  90                  95      

Asp Gly Ile Val Ala Leu Gly Gly Gly Val Val Gly Asp Leu Ala Gly 
            100                 105                 110         

Phe Val Ala Ser Thr Tyr Met Arg Gly Ile His Phe Val Gln Ile Pro 
        115                 120                 125             

Thr Ser Leu Thr Ala Gln Val Asp Ser Ser Ile Gly Gly Lys Thr Gly 
    130                 135                 140                 

Val Asn Thr Pro Phe Ala Lys Asn Met Val Gly Thr Phe Ala Gln Pro 
145                 150                 155                 160 

Asp Gly Val Leu Ile Asp Pro Leu Val Leu Glu Thr Leu Gly Lys Arg 
                165                 170                 175     

Glu Leu Ile Glu Gly Met Gly Glu Val Ile Lys Tyr Gly Leu Ile Glu 
            180                 185                 190         

Asp Pro Glu Leu Trp Ala Leu Leu Thr Gly Leu Asn Gly Ser Val Glu 
        195                 200                 205             

Ser Ile Leu Glu His Ala Glu Thr Leu Ile Glu His Ser Cys Gln Val 
    210                 215                 220                 

Lys Arg Lys Met Val Val Glu Asp Glu Leu Asp Asn Gly Ile Arg Leu 
225                 230                 235                 240 

Tyr Leu Asn Phe Gly His Thr Ile Gly His Ala Ile Glu Ala Thr Ala 
                245                 250                 255     

Gly Tyr Gly Lys Val Met His Gly Glu Ala Val Ala Met Gly Met Val 
            260                 265                 270         

Gln Ile Ser Lys Val Ala Glu Glu Lys Gly Leu Met Pro Ala Gly Ile 
        275                 280                 285             

Thr Gln Ser Ile Thr Glu Met Cys Gln Lys Phe Gly Leu Pro Val Asp 
    290                 295                 300                 

Tyr Glu Asn Trp Glu Val Gly Lys Leu Tyr Gln Ala Leu Thr His Asp 
305                 310                 315                 320 

Lys Lys Ala Arg Gly Asn Thr Leu Lys Leu Val Leu Val Pro Glu Leu 
                325                 330                 335     

Gly Ser Ala Thr Ile His Pro Val Ser Leu Glu Glu Met Lys Asp Tyr 
            340                 345                 350         

Leu Val Lys 
        355 

<210>   2789
<211>   852
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2789
atgaagcttg atggctatac acgtttagct gcagttgttg ccaatcctat taagcattct   60
atttctccct tcatccacaa tagagccttt gaggcgacag ctaccaacgg tgcttatgtg   120
gcttgggaga ttgaagcgag tgacttggta gaaacagtgg ccaatattcg tcgctaccag   180
atgtttggca tcaatctgtc catgccctat aaggagcagg tgattcctta tttggataag   240
ctgagcgatg aagcgcgctt gattggtgcg gttaatacgg ttgtcaatga gaatggcaat   300
ttaattggat ataatacaga tggcaaggga ttttttaagt gcttgccttc ttttacaatt   360
tcaggtaaaa agatgaccct gctgggtgca ggtggtgcgg ctaaatcaat cttggcacag   420
gctattttgg atggcgtcag tcagatttcg gtctttgttc gttccgtttc tatggaaaaa   480
acaagacctt acctagacaa gttacaggag cagacaggtt ttaaagtgga tttgtgtgct   540
ttagaatatg tttctgaact gcaagcaagg attgccgagt cggatttgct agttaatgcc   600
accagtgtgg gcatggatgg ccaatcctct cctgttcctg aaaacatagt cttaccagaa   660
actcttttag ttgcagatat catataccaa ccctttgaaa caccgttttt gaaatgggct   720
agaagtcagg gcaatccagc agtcaatggt ctgggaatgt tactctatca agctgcagaa   780
gcttttcaac tgtggacagg caaggaaatg ccgacagaag agatttggca gtctttaaca   840
gaaaaatacc aa                                                       852

<210>   2790
<211>   284
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   shikimate dehydrogenase (aroE)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903277 (e-162)

<400>   2790
Met Lys Leu Asp Gly Tyr Thr Arg Leu Ala Ala Val Val Ala Asn Pro 
1               5                   10                  15      

Ile Lys His Ser Ile Ser Pro Phe Ile His Asn Arg Ala Phe Glu Ala 
            20                  25                  30          

Thr Ala Thr Asn Gly Ala Tyr Val Ala Trp Glu Ile Glu Ala Ser Asp 
        35                  40                  45              

Leu Val Glu Thr Val Ala Asn Ile Arg Arg Tyr Gln Met Phe Gly Ile 
    50                  55                  60                  

Asn Leu Ser Met Pro Tyr Lys Glu Gln Val Ile Pro Tyr Leu Asp Lys 
65                  70                  75                  80  

Leu Ser Asp Glu Ala Arg Leu Ile Gly Ala Val Asn Thr Val Val Asn 
                85                  90                  95      

Glu Asn Gly Asn Leu Ile Gly Tyr Asn Thr Asp Gly Lys Gly Phe Phe 
            100                 105                 110         


Lys Cys Leu Pro Ser Phe Thr Ile Ser Gly Lys Lys Met Thr Leu Leu 
        115                 120                 125             

Gly Ala Gly Gly Ala Ala Lys Ser Ile Leu Ala Gln Ala Ile Leu Asp 
    130                 135                 140                 

Gly Val Ser Gln Ile Ser Val Phe Val Arg Ser Val Ser Met Glu Lys 
145                 150                 155                 160 

Thr Arg Pro Tyr Leu Asp Lys Leu Gln Glu Gln Thr Gly Phe Lys Val 
                165                 170                 175     

Asp Leu Cys Ala Leu Glu Tyr Val Ser Glu Leu Gln Ala Arg Ile Ala 
            180                 185                 190         

Glu Ser Asp Leu Leu Val Asn Ala Thr Ser Val Gly Met Asp Gly Gln 
        195                 200                 205             

Ser Ser Pro Val Pro Glu Asn Ile Val Leu Pro Glu Thr Leu Leu Val 
    210                 215                 220                 

Ala Asp Ile Ile Tyr Gln Pro Phe Glu Thr Pro Phe Leu Lys Trp Ala 
225                 230                 235                 240 

Arg Ser Gln Gly Asn Pro Ala Val Asn Gly Leu Gly Met Leu Leu Tyr 
                245                 250                 255     

Gln Ala Ala Glu Ala Phe Gln Leu Trp Thr Gly Lys Glu Met Pro Thr 
            260                 265                 270         

Glu Glu Ile Trp Gln Ser Leu Thr Glu Lys Tyr Gln 
        275                 280                 

<210>   2791
<211>   675
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2791
atgaaattaa tcgtttcagt aatgccaaga agtttagagg aggctcaggc tctggatgcc   60
acgaggtacc tggatgccga catcattgaa tggcgtgccg actatctgcc taaagaagcg   120
attttgcagg tagctccagc catttttgaa aaattcgcag gccgtgagtt ggttttcacg   180
ctacgaactc gctccgaagg tggagaaatc gacctttctc cagaagagta tatccatcta   240
atcaaggaag ttgcgcaact ctatcaacca gactatattg attttgagta ctatagctac   300
aaggatgttt ttgaggaaat gctggacttc ccaaatcttg ttttgagtta ccataatttc   360
caagaaacac ctgagaacat gatggaaatc ttgtcagagt tgacgatcct aaatccaaaa   420
cttgttaagg ttgcggtgat ggctcacacg gagcaggatg tcttagactt gatgaactat   480
acacgaggct ttaaaaccct caatcctgaa caggaatatg tgaccatttc tatgggtaag   540
gtgggcaagg tctctcgtat cactgcggat gtgactggtt cgagttggtc ttttgccagt   600
ctggatgagg ttagtgcccc tgggcagatt tctctagcta gcatgaaaaa aatcagggag   660
attttggatg aagct                                                    675

<210>   2792
<211>   225
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-dehydroquinate dehydratase (aroD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903278 (e-126)

<400>   2792
Met Lys Leu Ile Val Ser Val Met Pro Arg Ser Leu Glu Glu Ala Gln 
1               5                   10                  15      

Ala Leu Asp Ala Thr Arg Tyr Leu Asp Ala Asp Ile Ile Glu Trp Arg 
            20                  25                  30          

Ala Asp Tyr Leu Pro Lys Glu Ala Ile Leu Gln Val Ala Pro Ala Ile 
        35                  40                  45              

Phe Glu Lys Phe Ala Gly Arg Glu Leu Val Phe Thr Leu Arg Thr Arg 
    50                  55                  60                  

Ser Glu Gly Gly Glu Ile Asp Leu Ser Pro Glu Glu Tyr Ile His Leu 
65                  70                  75                  80  

Ile Lys Glu Val Ala Gln Leu Tyr Gln Pro Asp Tyr Ile Asp Phe Glu 
                85                  90                  95      

Tyr Tyr Ser Tyr Lys Asp Val Phe Glu Glu Met Leu Asp Phe Pro Asn 
            100                 105                 110         

Leu Val Leu Ser Tyr His Asn Phe Gln Glu Thr Pro Glu Asn Met Met 
        115                 120                 125             

Glu Ile Leu Ser Glu Leu Thr Ile Leu Asn Pro Lys Leu Val Lys Val 
    130                 135                 140                 

Ala Val Met Ala His Thr Glu Gln Asp Val Leu Asp Leu Met Asn Tyr 
145                 150                 155                 160 

Thr Arg Gly Phe Lys Thr Leu Asn Pro Glu Gln Glu Tyr Val Thr Ile 
                165                 170                 175     

Ser Met Gly Lys Val Gly Lys Val Ser Arg Ile Thr Ala Asp Val Thr 
            180                 185                 190         

Gly Ser Ser Trp Ser Phe Ala Ser Leu Asp Glu Val Ser Ala Pro Gly 
        195                 200                 205             

Gln Ile Ser Leu Ala Ser Met Lys Lys Ile Arg Glu Ile Leu Asp Glu 
    210                 215                 220                 

Ala 
225 

<210>   2793
<211>   1170
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2793
atggtagtta tgaatagaat aagagtcagc aaaagggttg aaaagaagct tgctaagggg   60
ctagttttac tagaagccag tgatcttgag aatgtcaatc ttaaggatca ggaagtagag   120
gtgcagggtc aggaaggaaa ctttcttggg actgcctacc tttctcagca aaacaagggc   180
ttgggctggt ttatcagcaa agacaaggtg gccttcaatc aagctttctt tgaaacgttg   240
tttagaaaag ccaaagaaaa gagaaacgcc tactatcaag atgatttgac aactgccttt   300
cgtctcttta atcaagaggg agatggcttt gggggtctga cagtggacct ttatggcgac   360
tacgccgtct tttcttggta taactcttat gtttatcaga ttcgtcagac tatatcagaa   420
gcctttagac aggttttccc tgaggtttta ggagcttatg agaaaatccg ctttaagggt   480
ttggactatg aatctgccca tgtttatggt caagaagcac ctgacttttt caatgtttta   540
gaaaatggtg tcctgtatca agtctttatg aatgatggct tgatgacagg aattttccta   600
gaccagcatg aggttcgcgg tagtttagtt gacggcttgg ctatgggtaa atccttactc   660
aatatgtttt cctacacagc ggctttttca gtagctgcgg ccatgggagg agctagccat   720
acaacttctg ttgatctagc caaacgttca cgagaattgt ctcaagcgca ttttcaggca   780
aatgggctca gcacagacga gcatcgtttt atagtcatgg atgtctttga gtatttcaaa   840
tatgccaaac gcaaagactt gacctacgat gtgattgtcc tagatccgcc tagctttgct   900
cggaataaaa aacaaacttt ctctgtggcc aaggattatc acaagttgat ttcccagagt   960
cttgagattt taaatccggg agggattatc attgccagta ccaatgctgc caatgtttcc   1020
cgtcagaaat ttacagaaca aattgataaa ggttttgcag gaagaagtta ccagatttta   1080
aacaaatatg gtcttccagc agattttgcc tataataaaa aagatgaaag tagtaattac   1140
ctcaaggtga ttagtatgaa ggttagtaaa                                    1170

<210>   2794
<211>   390
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903279 (0.E+01)

<400>   2794
Met Val Val Met Asn Arg Ile Arg Val Ser Lys Arg Val Glu Lys Lys 
1               5                   10                  15      

Leu Ala Lys Gly Leu Val Leu Leu Glu Ala Ser Asp Leu Glu Asn Val 
            20                  25                  30          

Asn Leu Lys Asp Gln Glu Val Glu Val Gln Gly Gln Glu Gly Asn Phe 
        35                  40                  45              

Leu Gly Thr Ala Tyr Leu Ser Gln Gln Asn Lys Gly Leu Gly Trp Phe 
    50                  55                  60                  

Ile Ser Lys Asp Lys Val Ala Phe Asn Gln Ala Phe Phe Glu Thr Leu 
65                  70                  75                  80  

Phe Arg Lys Ala Lys Glu Lys Arg Asn Ala Tyr Tyr Gln Asp Asp Leu 
                85                  90                  95      

Thr Thr Ala Phe Arg Leu Phe Asn Gln Glu Gly Asp Gly Phe Gly Gly 
            100                 105                 110         

Leu Thr Val Asp Leu Tyr Gly Asp Tyr Ala Val Phe Ser Trp Tyr Asn 
        115                 120                 125             

Ser Tyr Val Tyr Gln Ile Arg Gln Thr Ile Ser Glu Ala Phe Arg Gln 
    130                 135                 140                 

Val Phe Pro Glu Val Leu Gly Ala Tyr Glu Lys Ile Arg Phe Lys Gly 
145                 150                 155                 160 

Leu Asp Tyr Glu Ser Ala His Val Tyr Gly Gln Glu Ala Pro Asp Phe 
                165                 170                 175     

Phe Asn Val Leu Glu Asn Gly Val Leu Tyr Gln Val Phe Met Asn Asp 
            180                 185                 190         

Gly Leu Met Thr Gly Ile Phe Leu Asp Gln His Glu Val Arg Gly Ser 
        195                 200                 205             

Leu Val Asp Gly Leu Ala Met Gly Lys Ser Leu Leu Asn Met Phe Ser 
    210                 215                 220                 

Tyr Thr Ala Ala Phe Ser Val Ala Ala Ala Met Gly Gly Ala Ser His 
225                 230                 235                 240 

Thr Thr Ser Val Asp Leu Ala Lys Arg Ser Arg Glu Leu Ser Gln Ala 
                245                 250                 255     

His Phe Gln Ala Asn Gly Leu Ser Thr Asp Glu His Arg Phe Ile Val 
            260                 265                 270         

Met Asp Val Phe Glu Tyr Phe Lys Tyr Ala Lys Arg Lys Asp Leu Thr 
        275                 280                 285             

Tyr Asp Val Ile Val Leu Asp Pro Pro Ser Phe Ala Arg Asn Lys Lys 
    290                 295                 300                 

Gln Thr Phe Ser Val Ala Lys Asp Tyr His Lys Leu Ile Ser Gln Ser 
305                 310                 315                 320 

Leu Glu Ile Leu Asn Pro Gly Gly Ile Ile Ile Ala Ser Thr Asn Ala 
                325                 330                 335     

Ala Asn Val Ser Arg Gln Lys Phe Thr Glu Gln Ile Asp Lys Gly Phe 
            340                 345                 350         

Ala Gly Arg Ser Tyr Gln Ile Leu Asn Lys Tyr Gly Leu Pro Ala Asp 
        355                 360                 365             

Phe Ala Tyr Asn Lys Lys Asp Glu Ser Ser Asn Tyr Leu Lys Val Ile 
    370                 375                 380                 

Ser Met Lys Val Ser Lys 
385                 390 

<210>   2795
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2795
ttgctttttt actcttcttt taaaaaatgg tatactagac ttcctgcaaa actaggaagt   60
aaatgtgtaa gaatcacagt aaaaaatgct cttccgtctt ggaggagcat ttctttttat   120
caacgaaaat caaatagcaa acta                                          144

<210>   2796
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2796
Met Leu Phe Tyr Ser Ser Phe Lys Lys Trp Tyr Thr Arg Leu Pro Ala 
1               5                   10                  15      

Lys Leu Gly Ser Lys Cys Val Arg Ile Thr Val Lys Asn Ala Leu Pro 
            20                  25                  30          

Ser Trp Arg Ser Ile Ser Phe Tyr Gln Arg Lys Ser Asn Ser Lys Leu 
        35                  40                  45              


<210>   2797
<211>   1659
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2797
ttgctggtag aaaagaggag gttgcggatg cgtctcaagg tcattaaaaa attagttgat   60
atcaatatcc tttattcatc tcaagaagct aatctggcta atctacgaaa gaagcaggct   120
aagaatcctg ggaaaaaagt aaatgtttcc gctagagtct taagttctta cattttttcc   180
agtctcttga tgatcatctg ttttagtaat atagccattc attttccttt tgaggaaata   240
cctatttatt ttagctcgat gattgctatt ttactagtga ttgccttttc aacttcttta   300
acggcctttt acaatgtctt ttatgagagt aaggatttgg tatcgtatag gccctatgcc   360
tttaaagaat cagagattat aattgctaaa ggactgtctg tccttttgcc agctctaact   420
ggaattgtac caatcctagc ttattttctg gtcctctaca ttaggctagc tccttctcta   480
tggctgggtt tgcctttgat gctactgtcc ttgaccttat tatttgtctc tgtggctcta   540
gtgatggtag tggcagtgca tttcttggct caaactaggg tcttcagaaa gtatcagtct   600
attttttcga atgtgatgat tgggatagga gttctcatac ctttaatatt tatcttcttt   660
cttcagtcga cttttggaag tattgttgac aaagttagag acattccatt tctcctttat   720
cctcttcata tcttttacaa aatagcagtg gagccttttt cgacagaagc cttagtgggt   780
ctgctcgctt ggataggact aactctcttc ctgctttatc tgaccaaaaa gaaggtcctt   840
cctcgttttt atgacgtgat cctgcttaat agtgaggaga aggtcaaaaa agaacgtcgc   900
agcaaggaga gaatttcaac cactaaaaag ggattttttc gcatggtttt acgctaccac   960
ctcaccctct tgggacaggg gactggcgtg attacagtgc tttttacaag tgctttcctt   1020
ccttatctca tgatgatcgg tctgatttcc aaaatccgag attctcagat agttccagac   1080
attcatcctc catactggtt acccttgttt tttatagctc tctttatagc agttgtcaat   1140
aacaatatca ccagcctgca ttcaattgcc ttgtccttgg agagggaaaa tgttgatttt   1200
cttaagagtt taccctttga ctttgctcgt tatgtgaaag tgaaattttg gattatatat   1260
gctgtccagt cctttttacc agttctgact ttgcttggtc tttctctata tctaggcttg   1320
cccatcattt cgatgattta ccttcttgta gtctggatca ttgccagtgt catcctttct   1380
tgccaccatt actttaagga cgttaaaaat ctgtcaacca attggagtag cattacggac   1440
ctggtgaatc gttcaaatgg catagtcgcc atagttttat tgtttattta tagtgcaatc   1500
ctgatggccc ttgtaattgg gagcatattc ttggttcagt ctctctcccc tatccttgcc   1560
atcagcttgg gagtaggagc tcttatcgtc ttgcttgctc ttgctatttt tggctatcat   1620
tattacctgt cacgcatatt ggcagaaata gaaaaaaga                          1659

<210>   2798
<211>   553
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903280 (0.E+01)

<400>   2798
Met Leu Val Glu Lys Arg Arg Leu Arg Met Arg Leu Lys Val Ile Lys 
1               5                   10                  15      

Lys Leu Val Asp Ile Asn Ile Leu Tyr Ser Ser Gln Glu Ala Asn Leu 
            20                  25                  30          

Ala Asn Leu Arg Lys Lys Gln Ala Lys Asn Pro Gly Lys Lys Val Asn 
        35                  40                  45              

Val Ser Ala Arg Val Leu Ser Ser Tyr Ile Phe Ser Ser Leu Leu Met 
    50                  55                  60                  

Ile Ile Cys Phe Ser Asn Ile Ala Ile His Phe Pro Phe Glu Glu Ile 
65                  70                  75                  80  

Pro Ile Tyr Phe Ser Ser Met Ile Ala Ile Leu Leu Val Ile Ala Phe 
                85                  90                  95      

Ser Thr Ser Leu Thr Ala Phe Tyr Asn Val Phe Tyr Glu Ser Lys Asp 
            100                 105                 110         

Leu Val Ser Tyr Arg Pro Tyr Ala Phe Lys Glu Ser Glu Ile Ile Ile 
        115                 120                 125             

Ala Lys Gly Leu Ser Val Leu Leu Pro Ala Leu Thr Gly Ile Val Pro 
    130                 135                 140                 

Ile Leu Ala Tyr Phe Leu Val Leu Tyr Ile Arg Leu Ala Pro Ser Leu 
145                 150                 155                 160 

Trp Leu Gly Leu Pro Leu Met Leu Leu Ser Leu Thr Leu Leu Phe Val 
                165                 170                 175     

Ser Val Ala Leu Val Met Val Val Ala Val His Phe Leu Ala Gln Thr 
            180                 185                 190         

Arg Val Phe Arg Lys Tyr Gln Ser Ile Phe Ser Asn Val Met Ile Gly 
        195                 200                 205             

Ile Gly Val Leu Ile Pro Leu Ile Phe Ile Phe Phe Leu Gln Ser Thr 
    210                 215                 220                 

Phe Gly Ser Ile Val Asp Lys Val Arg Asp Ile Pro Phe Leu Leu Tyr 
225                 230                 235                 240 

Pro Leu His Ile Phe Tyr Lys Ile Ala Val Glu Pro Phe Ser Thr Glu 
                245                 250                 255     

Ala Leu Val Gly Leu Leu Ala Trp Ile Gly Leu Thr Leu Phe Leu Leu 
            260                 265                 270         

Tyr Leu Thr Lys Lys Lys Val Leu Pro Arg Phe Tyr Asp Val Ile Leu 
        275                 280                 285             

Leu Asn Ser Glu Glu Lys Val Lys Lys Glu Arg Arg Ser Lys Glu Arg 
    290                 295                 300                 

Ile Ser Thr Thr Lys Lys Gly Phe Phe Arg Met Val Leu Arg Tyr His 
305                 310                 315                 320 

Leu Thr Leu Leu Gly Gln Gly Thr Gly Val Ile Thr Val Leu Phe Thr 
                325                 330                 335     

Ser Ala Phe Leu Pro Tyr Leu Met Met Ile Gly Leu Ile Ser Lys Ile 
            340                 345                 350         

Arg Asp Ser Gln Ile Val Pro Asp Ile His Pro Pro Tyr Trp Leu Pro 
        355                 360                 365             

Leu Phe Phe Ile Ala Leu Phe Ile Ala Val Val Asn Asn Asn Ile Thr 
    370                 375                 380                 

Ser Leu His Ser Ile Ala Leu Ser Leu Glu Arg Glu Asn Val Asp Phe 
385                 390                 395                 400 

Leu Lys Ser Leu Pro Phe Asp Phe Ala Arg Tyr Val Lys Val Lys Phe 
                405                 410                 415     

Trp Ile Ile Tyr Ala Val Gln Ser Phe Leu Pro Val Leu Thr Leu Leu 
            420                 425                 430         

Gly Leu Ser Leu Tyr Leu Gly Leu Pro Ile Ile Ser Met Ile Tyr Leu 
        435                 440                 445             

Leu Val Val Trp Ile Ile Ala Ser Val Ile Leu Ser Cys His His Tyr 
    450                 455                 460                 

Phe Lys Asp Val Lys Asn Leu Ser Thr Asn Trp Ser Ser Ile Thr Asp 
465                 470                 475                 480 

Leu Val Asn Arg Ser Asn Gly Ile Val Ala Ile Val Leu Leu Phe Ile 
                485                 490                 495     

Tyr Ser Ala Ile Leu Met Ala Leu Val Ile Gly Ser Ile Phe Leu Val 
            500                 505                 510         

Gln Ser Leu Ser Pro Ile Leu Ala Ile Ser Leu Gly Val Gly Ala Leu 
        515                 520                 525             

Ile Val Leu Leu Ala Leu Ala Ile Phe Gly Tyr His Tyr Tyr Leu Ser 
    530                 535                 540                 

Arg Ile Leu Ala Glu Ile Glu Lys Arg 
545                 550             

<210>   2799
<211>   747
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2799
atgattgaat ttcaaaatgt tagtaagttg tatggtgata aagaggcctt gagtaatctc   60
aatttgcaga ttgaaaatgg agagattatg ggcttgattg gtcataatgg ggctggaaaa   120
tcgaccacta taaaatccct agtcagtatc atttcaccca gcagtggtcg tattttggta   180
gacggtcagg agttatcgga aaatcgcttg gctattaaac gaaagattgg ctacgtagca   240
gactcgcctg acttattttt acgcttaacg gccaatgaat tttgggaatt gatcgcctca   300
tcctatgatc tgagtagatc tgacttggag gctagtctag ctaggctatt gaacgttttt   360
gattttgctg aaaatcgcta tcaggttatt gaaactcttt ctcacggaat gcgtcagaaa   420
gtctttgtca tcggagcact cttgtctgat cccgatattt gggtcttgga tgaacccttg   480
actggtttgg atccccaggc tgcctttgat ttgaaacaga tgatgaagga acatgcacaa   540
aaagggaaga cagtcttgtt ttcaactcat gtcctagagg tggcagagca agtctgtgat   600
cggattgcca ttttgaaaaa ggggcatttg atttattgtg gtagtgtaga ggacttgaga   660
aaagattacc cagaccagtc tttggaaagt atctacctta gtcttgctgg tagaaaagag   720
gaggttgcgg atgcgtctca aggtcat                                       747

<210>   2800
<211>   249
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903281 (e-137)

<400>   2800
Met Ile Glu Phe Gln Asn Val Ser Lys Leu Tyr Gly Asp Lys Glu Ala 
1               5                   10                  15      

Leu Ser Asn Leu Asn Leu Gln Ile Glu Asn Gly Glu Ile Met Gly Leu 
            20                  25                  30          

Ile Gly His Asn Gly Ala Gly Lys Ser Thr Thr Ile Lys Ser Leu Val 
        35                  40                  45              

Ser Ile Ile Ser Pro Ser Ser Gly Arg Ile Leu Val Asp Gly Gln Glu 
    50                  55                  60                  

Leu Ser Glu Asn Arg Leu Ala Ile Lys Arg Lys Ile Gly Tyr Val Ala 
65                  70                  75                  80  

Asp Ser Pro Asp Leu Phe Leu Arg Leu Thr Ala Asn Glu Phe Trp Glu 
                85                  90                  95      

Leu Ile Ala Ser Ser Tyr Asp Leu Ser Arg Ser Asp Leu Glu Ala Ser 
            100                 105                 110         

Leu Ala Arg Leu Leu Asn Val Phe Asp Phe Ala Glu Asn Arg Tyr Gln 
        115                 120                 125             

Val Ile Glu Thr Leu Ser His Gly Met Arg Gln Lys Val Phe Val Ile 
    130                 135                 140                 

Gly Ala Leu Leu Ser Asp Pro Asp Ile Trp Val Leu Asp Glu Pro Leu 
145                 150                 155                 160 

Thr Gly Leu Asp Pro Gln Ala Ala Phe Asp Leu Lys Gln Met Met Lys 
                165                 170                 175     

Glu His Ala Gln Lys Gly Lys Thr Val Leu Phe Ser Thr His Val Leu 
            180                 185                 190         

Glu Val Ala Glu Gln Val Cys Asp Arg Ile Ala Ile Leu Lys Lys Gly 
        195                 200                 205             

His Leu Ile Tyr Cys Gly Ser Val Glu Asp Leu Arg Lys Asp Tyr Pro 
    210                 215                 220                 

Asp Gln Ser Leu Glu Ser Ile Tyr Leu Ser Leu Ala Gly Arg Lys Glu 
225                 230                 235                 240 

Glu Val Ala Asp Ala Ser Gln Gly His 
                245                 

<210>   2801
<211>   1452
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2801
atgcaaaatc aaacactcat gcaatacttt gaatggtatc tgccccacga cggtcaacac   60
tggacgcgtc tggctgaaaa tgctccacac ctagctcatc tggggatcag tcacgtctgg   120
atgccaccag ccttcaaggc aaccaacgaa aaagatgtcg gctatggggt ctatgactta   180
tttgacttag gagagttcaa ccaaaaaggg actgtccgca ccaagtatgg tttcaaagaa   240
gactatcttc aagccattca agcccttaaa gcacagggaa ttcaacctat ggccgatgta   300
gttctcaacc acaaggctgc tgccgatcac agggaagcct ttcaggttat cgaagttgat   360
cctgtagacc gtacagttga acttggagaa cccttcacca tcaatggctg gactagtttt   420
accttcgatg gtcgccaaga tacctataat ggcttccact ggcattggta ccacttcacc   480
ggtacagact acgatgccaa acgcagtaaa tctgggattt atctgatcca aggggacaac   540
aagggctggg ccaacgagga attggtcgat aacgaaaacg gaaactacga ctacctcatg   600
tatgccgacc tagactttaa acatcctgaa gtcatccaaa acatctatga ctgggctgat   660
tggttcatgg aaacgactgg tgtagctggt ttccgtttgg atgccgttaa gcatattgac   720
tctttcttta tgcgcaactt catccgcgat atgaaggaaa aatacggtga cgatttctat   780
gtttttggtg aattttggaa cccagacaag gaagccaatc tggactatct cgaaaaaacg   840
gaagaacact ttgaccttgt cgatgttcgt ctccaccaga atctctttga agccagtcaa   900
gctggcgcaa actatgacct tcgtggcatt ttcacagata gcctggttga actcaagcct   960
gacaaggctg tgacttttgt cgacaaccac gatacccaac gaggacaagc ccttgagtct   1020
accgttgaag aatggttcaa gccagcagcc tatgccctca ttttgttacg ccaagacggc   1080
cttccatgtg tcttttacgg agactactat gggatttcag ggcagtatgc tcaagaagat   1140
ttcaaagaaa tccttgaccg cctcctagcc atccgaaaag atttggccta tggagaacaa   1200
aatgactact ttgaccatgc taactgtatc ggttgggtac gttcaggtgc tgaaaatcaa   1260
tccccaatcg cagtccttat ctcaaatgac caagaaaaca gcaagtcaat gtttgtcggt   1320
caagaatgga ctaatcaaac ctttgtagat ttacttggta accaccaagg tcaagttaca   1380
attgatgagg aaggttatgg acaattccct gtctcagcta gatccgtaag tgtctgggca   1440
gtcaatacca tc                                                       1452

<210>   2802
<211>   484
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alpha-amylase (amy)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903282 (0.E+01)

<400>   2802
Met Gln Asn Gln Thr Leu Met Gln Tyr Phe Glu Trp Tyr Leu Pro His 
1               5                   10                  15      

Asp Gly Gln His Trp Thr Arg Leu Ala Glu Asn Ala Pro His Leu Ala 
            20                  25                  30          

His Leu Gly Ile Ser His Val Trp Met Pro Pro Ala Phe Lys Ala Thr 
        35                  40                  45              

Asn Glu Lys Asp Val Gly Tyr Gly Val Tyr Asp Leu Phe Asp Leu Gly 
    50                  55                  60                  

Glu Phe Asn Gln Lys Gly Thr Val Arg Thr Lys Tyr Gly Phe Lys Glu 
65                  70                  75                  80  

Asp Tyr Leu Gln Ala Ile Gln Ala Leu Lys Ala Gln Gly Ile Gln Pro 
                85                  90                  95      

Met Ala Asp Val Val Leu Asn His Lys Ala Ala Ala Asp His Arg Glu 
            100                 105                 110         

Ala Phe Gln Val Ile Glu Val Asp Pro Val Asp Arg Thr Val Glu Leu 
        115                 120                 125             

Gly Glu Pro Phe Thr Ile Asn Gly Trp Thr Ser Phe Thr Phe Asp Gly 
    130                 135                 140                 

Arg Gln Asp Thr Tyr Asn Gly Phe His Trp His Trp Tyr His Phe Thr 
145                 150                 155                 160 

Gly Thr Asp Tyr Asp Ala Lys Arg Ser Lys Ser Gly Ile Tyr Leu Ile 
                165                 170                 175     

Gln Gly Asp Asn Lys Gly Trp Ala Asn Glu Glu Leu Val Asp Asn Glu 
            180                 185                 190         

Asn Gly Asn Tyr Asp Tyr Leu Met Tyr Ala Asp Leu Asp Phe Lys His 
        195                 200                 205             

Pro Glu Val Ile Gln Asn Ile Tyr Asp Trp Ala Asp Trp Phe Met Glu 
    210                 215                 220                 

Thr Thr Gly Val Ala Gly Phe Arg Leu Asp Ala Val Lys His Ile Asp 
225                 230                 235                 240 

Ser Phe Phe Met Arg Asn Phe Ile Arg Asp Met Lys Glu Lys Tyr Gly 
                245                 250                 255     

Asp Asp Phe Tyr Val Phe Gly Glu Phe Trp Asn Pro Asp Lys Glu Ala 
            260                 265                 270         

Asn Leu Asp Tyr Leu Glu Lys Thr Glu Glu His Phe Asp Leu Val Asp 

        275                 280                 285             

Val Arg Leu His Gln Asn Leu Phe Glu Ala Ser Gln Ala Gly Ala Asn 
    290                 295                 300                 

Tyr Asp Leu Arg Gly Ile Phe Thr Asp Ser Leu Val Glu Leu Lys Pro 
305                 310                 315                 320 

Asp Lys Ala Val Thr Phe Val Asp Asn His Asp Thr Gln Arg Gly Gln 
                325                 330                 335     

Ala Leu Glu Ser Thr Val Glu Glu Trp Phe Lys Pro Ala Ala Tyr Ala 
            340                 345                 350         

Leu Ile Leu Leu Arg Gln Asp Gly Leu Pro Cys Val Phe Tyr Gly Asp 
        355                 360                 365             

Tyr Tyr Gly Ile Ser Gly Gln Tyr Ala Gln Glu Asp Phe Lys Glu Ile 
    370                 375                 380                 

Leu Asp Arg Leu Leu Ala Ile Arg Lys Asp Leu Ala Tyr Gly Glu Gln 
385                 390                 395                 400 

Asn Asp Tyr Phe Asp His Ala Asn Cys Ile Gly Trp Val Arg Ser Gly 
                405                 410                 415     

Ala Glu Asn Gln Ser Pro Ile Ala Val Leu Ile Ser Asn Asp Gln Glu 
            420                 425                 430         

Asn Ser Lys Ser Met Phe Val Gly Gln Glu Trp Thr Asn Gln Thr Phe 
        435                 440                 445             

Val Asp Leu Leu Gly Asn His Gln Gly Gln Val Thr Ile Asp Glu Glu 
    450                 455                 460                 

Gly Tyr Gly Gln Phe Pro Val Ser Ala Arg Ser Val Ser Val Trp Ala 
465                 470                 475                 480 

Val Asn Thr Ile 
                

<210>   2803
<211>   2616
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2803
atgaaacaac tatctagtgc acaagtacgc caaatgtggc ttgatttctg ggcgaccaaa   60
ggtcactcag tagaaccatc agtaagtttg gttcctgtaa atgacccaac tcttttgtgg   120
atcaactctg gggtagcaac ccttaagaaa tactttgacg ggaccattat ccctgaaaat   180
ccacgtatta ccaatgccca aaaggctatc cgtaccaacg acatcgaaaa cgtagggaag   240
accgcgcgtc accataccat gtttgaaatg ctggggaact tctctatcgg ggattacttc   300
cgtgacgaag ctatcacttg ggcttatgag cttttgacaa gccctgaatg gtttgatttc   360
cctgctgaaa aactttacat gacctactat ccagacgata aagattctta caaccgctgg   420
attgaagtgg gagtggatcc aagtcacttg attccaattg aggacaactt ctgggaaatc   480
ggtgcgggac cttctggacc agatacagaa atcttctttg accgtgggga agcctttgac   540
ccagaaaata tcggtcttcg cctgcttgca gaagatattg aaaacgaccg ttatattgaa   600
atctggaaca tcgttttgtc acaatttaac gcagaccctg ctgttcctcg tagcgaatac   660
aaggaattgc cacataagaa cattgatacg ggcgctggtt tggagcgttt ggtggccgtt   720
atccaagggg ctaagaccaa ctttgaaacg gacctcttca tgccgattat ccgtgaagtc   780
gagaaattgt ctggtaaggt ttatgaccaa gatggcgaca acatgagctt caaggttatc   840
gcagaccaca ttcgttctct ttcatttgct atcggtgatg gtgcccttcc aggaaatgaa   900
ggtcgtggtt atgttcttcg tcgtcttctc cgtcgtgctt ctatgcatgg tcaaaaattg   960
ggtatcaacg agcctttcct ttacaaattg gttccaactg ttggaaaaat catggaaagc   1020
tactacccag aagtgcttga gaaacgtgac tttattgaga aaatcgttaa gagcgaagaa   1080
gaatcatttg cccgtaccct tcactcaggt caacactttg cccaaggcat tgtagcagac   1140
ttgaaagaaa aaggtcaatc tgttatcgct ggttcagatg tcttcaaact ctatgatact   1200
tatgggttcc cagttgaatt gactgaagaa atcgctgaag aagctggtat gactgtagac   1260
cgtgaaggtt ttgaagcagc catgaaagaa cagcaagaac gcgcgcgtgc gtcagctgtc   1320
aagggtggct caatgggtat gcaaaatgaa actcttcaaa acatcactgt agaaagtgtc   1380
ttcaactaca atgctagcca attgtcttct aaattggtag ctatcgttgc tgacaatgca   1440
gaagtaggag ctgtttcaga aggaactgcc tctcttatct ttgcggaaac gtcattttat   1500
gctgaaatgg gtggacaggt agctgactac ggacaaatct tggatgagtc aggtaaggtt   1560
gtggctactg tgaccaatgt tcagaaagcc ccaaatggtc aagcccttca tacagttgaa   1620
gtccttgcac cgcttgcctt gaaccaagaa tataccttgg caattgatag caatcgccgt   1680
caccgtgtca tgaaaaacca cactgcgact catttgcttc acgctgccct tcacaatatc   1740
cttggaaacc acgcaacaca ggcaggatct cttaacgaag ttgaattcct tcgctttgac   1800
tttacccact tccaagcagt aactgctgag gaacttcgtg cgattgaaca gcaagttaac   1860
gagaaaattt gggaagcact tgaagtgaag acagttgaaa cggatattga cactgctaaa   1920
gaaatgggag ctatggccct ctttggtgag aaatacggca aggaagttcg tgtcgtgact   1980
atcggtgact actctattga actttgtggt ggtactcatg ttgacaacac ttctgagatt   2040
ggtctcttca aaattgtcaa agaagaagga atcggttcag gaactcgccg tatcttggca   2100
gtgactggta aggaagcctt tgaagcctat cgtgaacaag aggatgctct taaagctatc   2160
gcagcaacct tgaaagcacc tcaagtcaag gaagtacctc acaaggtaga aggacttcaa   2220
gaacaacttc gtcaacttca aaaagaaaat gctgagttga aagaaaaagc cgcagctgca   2280
gccgcaggcg atatcttcaa agatgttaag gaagtcaacg gtcatcgtta cattgctagt   2340
caagtgtctg tatccgatgc cggtgccctt cgtacttttg cagataactg gaaacaaaaa   2400
gactactctg atcttcttgt cctagttgcc gctatcggtg acaaagtcaa tgtccttgta   2460
gcaagcaaga caaaagacct tcatgcagga aaccttgtca aagaattagc accaatcatc   2520
gatggacgtg gtggtggtaa accagatatg gccatggcag gaggaagcaa ccaacctaag   2580
atccaagaat tgttggatgc agtagcaggt aaattg                             2616

<210>   2804
<211>   872
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   alanyl-tRNA synthetase (alaS)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903283 (0.E+01)

<400>   2804
Met Lys Gln Leu Ser Ser Ala Gln Val Arg Gln Met Trp Leu Asp Phe 
1               5                   10                  15      

Trp Ala Thr Lys Gly His Ser Val Glu Pro Ser Val Ser Leu Val Pro 
            20                  25                  30          

Val Asn Asp Pro Thr Leu Leu Trp Ile Asn Ser Gly Val Ala Thr Leu 
        35                  40                  45              

Lys Lys Tyr Phe Asp Gly Thr Ile Ile Pro Glu Asn Pro Arg Ile Thr 
    50                  55                  60                  

Asn Ala Gln Lys Ala Ile Arg Thr Asn Asp Ile Glu Asn Val Gly Lys 
65                  70                  75                  80  

Thr Ala Arg His His Thr Met Phe Glu Met Leu Gly Asn Phe Ser Ile 
                85                  90                  95      

Gly Asp Tyr Phe Arg Asp Glu Ala Ile Thr Trp Ala Tyr Glu Leu Leu 
            100                 105                 110         

Thr Ser Pro Glu Trp Phe Asp Phe Pro Ala Glu Lys Leu Tyr Met Thr 
        115                 120                 125             

Tyr Tyr Pro Asp Asp Lys Asp Ser Tyr Asn Arg Trp Ile Glu Val Gly 
    130                 135                 140                 

Val Asp Pro Ser His Leu Ile Pro Ile Glu Asp Asn Phe Trp Glu Ile 
145                 150                 155                 160 

Gly Ala Gly Pro Ser Gly Pro Asp Thr Glu Ile Phe Phe Asp Arg Gly 
                165                 170                 175     


Glu Ala Phe Asp Pro Glu Asn Ile Gly Leu Arg Leu Leu Ala Glu Asp 
            180                 185                 190         

Ile Glu Asn Asp Arg Tyr Ile Glu Ile Trp Asn Ile Val Leu Ser Gln 
        195                 200                 205             

Phe Asn Ala Asp Pro Ala Val Pro Arg Ser Glu Tyr Lys Glu Leu Pro 
    210                 215                 220                 

His Lys Asn Ile Asp Thr Gly Ala Gly Leu Glu Arg Leu Val Ala Val 
225                 230                 235                 240 

Ile Gln Gly Ala Lys Thr Asn Phe Glu Thr Asp Leu Phe Met Pro Ile 
                245                 250                 255     

Ile Arg Glu Val Glu Lys Leu Ser Gly Lys Val Tyr Asp Gln Asp Gly 
            260                 265                 270         

Asp Asn Met Ser Phe Lys Val Ile Ala Asp His Ile Arg Ser Leu Ser 
        275                 280                 285             

Phe Ala Ile Gly Asp Gly Ala Leu Pro Gly Asn Glu Gly Arg Gly Tyr 
    290                 295                 300                 

Val Leu Arg Arg Leu Leu Arg Arg Ala Ser Met His Gly Gln Lys Leu 
305                 310                 315                 320 

Gly Ile Asn Glu Pro Phe Leu Tyr Lys Leu Val Pro Thr Val Gly Lys 
                325                 330                 335     

Ile Met Glu Ser Tyr Tyr Pro Glu Val Leu Glu Lys Arg Asp Phe Ile 
            340                 345                 350         

Glu Lys Ile Val Lys Ser Glu Glu Glu Ser Phe Ala Arg Thr Leu His 
        355                 360                 365             

Ser Gly Gln His Phe Ala Gln Gly Ile Val Ala Asp Leu Lys Glu Lys 
    370                 375                 380                 

Gly Gln Ser Val Ile Ala Gly Ser Asp Val Phe Lys Leu Tyr Asp Thr 
385                 390                 395                 400 

Tyr Gly Phe Pro Val Glu Leu Thr Glu Glu Ile Ala Glu Glu Ala Gly 
                405                 410                 415     

Met Thr Val Asp Arg Glu Gly Phe Glu Ala Ala Met Lys Glu Gln Gln 
            420                 425                 430         

Glu Arg Ala Arg Ala Ser Ala Val Lys Gly Gly Ser Met Gly Met Gln 
        435                 440                 445             

Asn Glu Thr Leu Gln Asn Ile Thr Val Glu Ser Val Phe Asn Tyr Asn 
    450                 455                 460                 

Ala Ser Gln Leu Ser Ser Lys Leu Val Ala Ile Val Ala Asp Asn Ala 
465                 470                 475                 480 

Glu Val Gly Ala Val Ser Glu Gly Thr Ala Ser Leu Ile Phe Ala Glu 
                485                 490                 495     

Thr Ser Phe Tyr Ala Glu Met Gly Gly Gln Val Ala Asp Tyr Gly Gln 
            500                 505                 510         


Ile Leu Asp Glu Ser Gly Lys Val Val Ala Thr Val Thr Asn Val Gln 
        515                 520                 525             

Lys Ala Pro Asn Gly Gln Ala Leu His Thr Val Glu Val Leu Ala Pro 
    530                 535                 540                 

Leu Ala Leu Asn Gln Glu Tyr Thr Leu Ala Ile Asp Ser Asn Arg Arg 
545                 550                 555                 560 

His Arg Val Met Lys Asn His Thr Ala Thr His Leu Leu His Ala Ala 
                565                 570                 575     

Leu His Asn Ile Leu Gly Asn His Ala Thr Gln Ala Gly Ser Leu Asn 
            580                 585                 590         

Glu Val Glu Phe Leu Arg Phe Asp Phe Thr His Phe Gln Ala Val Thr 
        595                 600                 605             

Ala Glu Glu Leu Arg Ala Ile Glu Gln Gln Val Asn Glu Lys Ile Trp 
    610                 615                 620                 

Glu Ala Leu Glu Val Lys Thr Val Glu Thr Asp Ile Asp Thr Ala Lys 
625                 630                 635                 640 

Glu Met Gly Ala Met Ala Leu Phe Gly Glu Lys Tyr Gly Lys Glu Val 
                645                 650                 655     

Arg Val Val Thr Ile Gly Asp Tyr Ser Ile Glu Leu Cys Gly Gly Thr 
            660                 665                 670         

His Val Asp Asn Thr Ser Glu Ile Gly Leu Phe Lys Ile Val Lys Glu 
        675                 680                 685             

Glu Gly Ile Gly Ser Gly Thr Arg Arg Ile Leu Ala Val Thr Gly Lys 
    690                 695                 700                 

Glu Ala Phe Glu Ala Tyr Arg Glu Gln Glu Asp Ala Leu Lys Ala Ile 
705                 710                 715                 720 

Ala Ala Thr Leu Lys Ala Pro Gln Val Lys Glu Val Pro His Lys Val 
                725                 730                 735     

Glu Gly Leu Gln Glu Gln Leu Arg Gln Leu Gln Lys Glu Asn Ala Glu 
            740                 745                 750         

Leu Lys Glu Lys Ala Ala Ala Ala Ala Ala Gly Asp Ile Phe Lys Asp 
        755                 760                 765             

Val Lys Glu Val Asn Gly His Arg Tyr Ile Ala Ser Gln Val Ser Val 
    770                 775                 780                 

Ser Asp Ala Gly Ala Leu Arg Thr Phe Ala Asp Asn Trp Lys Gln Lys 
785                 790                 795                 800 

Asp Tyr Ser Asp Leu Leu Val Leu Val Ala Ala Ile Gly Asp Lys Val 
                805                 810                 815     

Asn Val Leu Val Ala Ser Lys Thr Lys Asp Leu His Ala Gly Asn Leu 
            820                 825                 830         

Val Lys Glu Leu Ala Pro Ile Ile Asp Gly Arg Gly Gly Gly Lys Pro 
        835                 840                 845             

Asp Met Ala Met Ala Gly Gly Ser Asn Gln Pro Lys Ile Gln Glu Leu 
    850                 855                 860                 

Leu Asp Ala Val Ala Gly Lys Leu 
865                 870         

<210>   2805
<211>   495
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2805
ttggaggtgt tgatgaaaac atttcttgtc aaacaaaagt ttcgtcttgg aggcgaacgc   60
ttcgctatca aggatgacag gggagaaatt gcctatcagg tggagggatc attttttaag   120
attcctaaaa cctttaccat ctatgatgcg gctggtgaac aagtcagtga gattagtaaa   180
gaaatcttga ccttgcttcc tcgttttgaa attcagcttc gggatggctc gagttttgtc   240
attcgtaaga agttgacctt ctggcgagat aagtatgagt ttgataatct aggtcttcgt   300
atcgagggca atatctggga tttgaatttc aaattgctgg atgatcgcga tcagttgatt   360
gcggaaatta agaaggaact cttccatctg acttctacct ataccgtaac ggttcttgaa   420
gacgcttatg cagacctagt catttccctc tgtgtcgcga ttgactatgt ggaaatgctg   480
gaaagccaat cacat                                                    495

<210>   2806
<211>   165
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903284 (4.E-91)

<400>   2806
Met Glu Val Leu Met Lys Thr Phe Leu Val Lys Gln Lys Phe Arg Leu 
1               5                   10                  15      

Gly Gly Glu Arg Phe Ala Ile Lys Asp Asp Arg Gly Glu Ile Ala Tyr 
            20                  25                  30          

Gln Val Glu Gly Ser Phe Phe Lys Ile Pro Lys Thr Phe Thr Ile Tyr 
        35                  40                  45              

Asp Ala Ala Gly Glu Gln Val Ser Glu Ile Ser Lys Glu Ile Leu Thr 
    50                  55                  60                  

Leu Leu Pro Arg Phe Glu Ile Gln Leu Arg Asp Gly Ser Ser Phe Val 
65                  70                  75                  80  

Ile Arg Lys Lys Leu Thr Phe Trp Arg Asp Lys Tyr Glu Phe Asp Asn 
                85                  90                  95      

Leu Gly Leu Arg Ile Glu Gly Asn Ile Trp Asp Leu Asn Phe Lys Leu 
            100                 105                 110         

Leu Asp Asp Arg Asp Gln Leu Ile Ala Glu Ile Lys Lys Glu Leu Phe 
        115                 120                 125             

His Leu Thr Ser Thr Tyr Thr Val Thr Val Leu Glu Asp Ala Tyr Ala 
    130                 135                 140                 

Asp Leu Val Ile Ser Leu Cys Val Ala Ile Asp Tyr Val Glu Met Leu 
145                 150                 155                 160 

Glu Ser Gln Ser His 
                165 

<210>   2807
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2807
atgaaaatgt ctactttttt caaaaaaagt ttctggccaa cctttatgat tgttaaccaa   60
actgctatac tattccattt aaaggatggc ttggatcgac aatacctaac aactgagtcc   120
atatattggg tgataggcac ctttatattt ggaaatattc tagtagctgt gtttagtaat   180
atgaaaattt gggataaaaa gaaaaatggc agtaagaaaa aatatatcct gaaaaag      237

<210>   2808
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903285 (3.E-43)

<400>   2808
Met Lys Met Ser Thr Phe Phe Lys Lys Ser Phe Trp Pro Thr Phe Met 
1               5                   10                  15      

Ile Val Asn Gln Thr Ala Ile Leu Phe His Leu Lys Asp Gly Leu Asp 
            20                  25                  30          

Arg Gln Tyr Leu Thr Thr Glu Ser Ile Tyr Trp Val Ile Gly Thr Phe 
        35                  40                  45              

Ile Phe Gly Asn Ile Leu Val Ala Val Phe Ser Asn Met Lys Ile Trp 
    50                  55                  60                  

Asp Lys Lys Lys Asn Gly Ser Lys Lys Lys Tyr Ile Leu Lys Lys 

65                  70                  75                  

<210>   2809
<211>   1068
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2809
atgaaaaaaa tctattcatt tttagcagga attgcagcga ttatccttgt cttgtgggga   60
attgcgactc atttagatag taaaatcaat agtcgagata gtcaaaaatt ggttatctat   120
aactggggag actatatcga tcctgaactc ttgactcagt ttacagaaga aacaggaatt   180
caagttcagt acgagacttt tgactccaac gaagccatgt acactaagat aaagcagggt   240
ggaacgacct acgatattgc cattccaagt gaatacatga ttaacaagat gaaggacgaa   300
gacctcttgg ttccgcttga ttattcaaaa attgaaggaa tcgaaaatat cggaccagag   360
tttctcaacc agtcctttga cccaggtaat aaattctcca tcccttactt ctggggaacc   420
ttaggaattg tctacaacga aaccatggta gatgaagcgc ctgagcattg ggatgacctt   480
tggaagccgg agtataagaa ttctatcatg ctctttgatg gggcgcgtga ggtgctggga   540
ctaggactca attccctcgg ctacagcctc aactccaagg atctgcagca gttggaagag   600
acagtggata agctctacaa actgactcca aatatcaagg ctatcgttgc ggacgagatg   660
aagggctata tgattcagaa taatgttgca atcggcgtga ccttctctgg tgaagccagc   720
caaatgttag aaaaaaatga aaatctacgt tatgtggtac cgacagaggc cagcaatctt   780
tggtttgaca atatggtcat tcccaaaaca gttaaaaacc aaaactcagc ctatgccttt   840
atcaacttta tgttgaaacc tgaaaatgct ctccaaaatg cggagtatgt cggctattca   900
acaccaaacc taccagcgaa ggaattgctc ccagaggaaa caaaggaaga taaggccttc   960
tatcccgatg ttgaaaccat gaaacaccta gaagtttatg agaaatttga ccataaatgg   1020
acagggaaat atagcgacct cttcctacag tttaaaatgt atcggaag                1068

<210>   2810
<211>   356
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spermidine/putrescine ABC transporter, spermidine/putrescine-binding pr
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903286 (0.E+01)

<400>   2810
Met Lys Lys Ile Tyr Ser Phe Leu Ala Gly Ile Ala Ala Ile Ile Leu 
1               5                   10                  15      

Val Leu Trp Gly Ile Ala Thr His Leu Asp Ser Lys Ile Asn Ser Arg 
            20                  25                  30          

Asp Ser Gln Lys Leu Val Ile Tyr Asn Trp Gly Asp Tyr Ile Asp Pro 
        35                  40                  45              

Glu Leu Leu Thr Gln Phe Thr Glu Glu Thr Gly Ile Gln Val Gln Tyr 
    50                  55                  60                  

Glu Thr Phe Asp Ser Asn Glu Ala Met Tyr Thr Lys Ile Lys Gln Gly 
65                  70                  75                  80  

Gly Thr Thr Tyr Asp Ile Ala Ile Pro Ser Glu Tyr Met Ile Asn Lys 
                85                  90                  95      

Met Lys Asp Glu Asp Leu Leu Val Pro Leu Asp Tyr Ser Lys Ile Glu 
            100                 105                 110         

Gly Ile Glu Asn Ile Gly Pro Glu Phe Leu Asn Gln Ser Phe Asp Pro 
        115                 120                 125             

Gly Asn Lys Phe Ser Ile Pro Tyr Phe Trp Gly Thr Leu Gly Ile Val 
    130                 135                 140                 

Tyr Asn Glu Thr Met Val Asp Glu Ala Pro Glu His Trp Asp Asp Leu 
145                 150                 155                 160 

Trp Lys Pro Glu Tyr Lys Asn Ser Ile Met Leu Phe Asp Gly Ala Arg 
                165                 170                 175     

Glu Val Leu Gly Leu Gly Leu Asn Ser Leu Gly Tyr Ser Leu Asn Ser 
            180                 185                 190         

Lys Asp Leu Gln Gln Leu Glu Glu Thr Val Asp Lys Leu Tyr Lys Leu 
        195                 200                 205             

Thr Pro Asn Ile Lys Ala Ile Val Ala Asp Glu Met Lys Gly Tyr Met 
    210                 215                 220                 

Ile Gln Asn Asn Val Ala Ile Gly Val Thr Phe Ser Gly Glu Ala Ser 
225                 230                 235                 240 

Gln Met Leu Glu Lys Asn Glu Asn Leu Arg Tyr Val Val Pro Thr Glu 
                245                 250                 255     

Ala Ser Asn Leu Trp Phe Asp Asn Met Val Ile Pro Lys Thr Val Lys 
            260                 265                 270         

Asn Gln Asn Ser Ala Tyr Ala Phe Ile Asn Phe Met Leu Lys Pro Glu 
        275                 280                 285             

Asn Ala Leu Gln Asn Ala Glu Tyr Val Gly Tyr Ser Thr Pro Asn Leu 
    290                 295                 300                 

Pro Ala Lys Glu Leu Leu Pro Glu Glu Thr Lys Glu Asp Lys Ala Phe 
305                 310                 315                 320 

Tyr Pro Asp Val Glu Thr Met Lys His Leu Glu Val Tyr Glu Lys Phe 
                325                 330                 335     

Asp His Lys Trp Thr Gly Lys Tyr Ser Asp Leu Phe Leu Gln Phe Lys 
            340                 345                 350         

Met Tyr Arg Lys 
        355     

<210>   2811
<211>   771
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2811
atgaaaaaat ttgccaacct ttatctggga ctggtctttc tggtcctcta cctgcctatc   60
ttttacttga ttggctatgc ctttaatgct ggtgatgata tgaatagctt tacaggtttt   120
agctggactc actttgaaac catgtttgga gatgggagac tcatgctgat tttggctcag   180
acatttttct tggccttcct atcagccttg atagcgacca ttatcgggac ttttggtgcc   240
atttacatct accagtctcg taagaaatac caagaagcct ttctatcact caataatatc   300
ctcatggttg cgcctgacgt tatgattggt gctagcttct tgattctctt tacccaactc   360
aagttttcac ttggcttttt gaccgttcta tctagtcacg tggccttctc cattcctatc   420
gtggtcttga tggtcttgcc tcgactcaag gaaatgaatg gcgacatgat tcatgcggcc   480
tatgacttgg gagctagtca atttcagatg ttcaaggaaa tcatgcttcc ttacctgact   540
ccgtctatca ttactggtta tttcatggcc ttcacctatt cgttagatga ctttgccgtg   600
accttctttg taacaggaaa tggcttttca accctatcag tcgagattta ctctcgtgct   660
cgcaagggga tttccttaga aatcaatgcc ctgtctgctc tagtctttct ctttagtatt   720
atcctagttg taggttatta ctttatctct cgtgagaagg aggagcaagc a            771

<210>   2812
<211>   257
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spermidine/putrescine ABC transporter, permease protein (potC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903287 (e-143)

<400>   2812
Met Lys Lys Phe Ala Asn Leu Tyr Leu Gly Leu Val Phe Leu Val Leu 
1               5                   10                  15      

Tyr Leu Pro Ile Phe Tyr Leu Ile Gly Tyr Ala Phe Asn Ala Gly Asp 
            20                  25                  30          

Asp Met Asn Ser Phe Thr Gly Phe Ser Trp Thr His Phe Glu Thr Met 
        35                  40                  45              

Phe Gly Asp Gly Arg Leu Met Leu Ile Leu Ala Gln Thr Phe Phe Leu 
    50                  55                  60                  

Ala Phe Leu Ser Ala Leu Ile Ala Thr Ile Ile Gly Thr Phe Gly Ala 
65                  70                  75                  80  

Ile Tyr Ile Tyr Gln Ser Arg Lys Lys Tyr Gln Glu Ala Phe Leu Ser 
                85                  90                  95      

Leu Asn Asn Ile Leu Met Val Ala Pro Asp Val Met Ile Gly Ala Ser 
            100                 105                 110         

Phe Leu Ile Leu Phe Thr Gln Leu Lys Phe Ser Leu Gly Phe Leu Thr 
        115                 120                 125             

Val Leu Ser Ser His Val Ala Phe Ser Ile Pro Ile Val Val Leu Met 
    130                 135                 140                 

Val Leu Pro Arg Leu Lys Glu Met Asn Gly Asp Met Ile His Ala Ala 
145                 150                 155                 160 

Tyr Asp Leu Gly Ala Ser Gln Phe Gln Met Phe Lys Glu Ile Met Leu 
                165                 170                 175     

Pro Tyr Leu Thr Pro Ser Ile Ile Thr Gly Tyr Phe Met Ala Phe Thr 
            180                 185                 190         

Tyr Ser Leu Asp Asp Phe Ala Val Thr Phe Phe Val Thr Gly Asn Gly 
        195                 200                 205             

Phe Ser Thr Leu Ser Val Glu Ile Tyr Ser Arg Ala Arg Lys Gly Ile 
    210                 215                 220                 

Ser Leu Glu Ile Asn Ala Leu Ser Ala Leu Val Phe Leu Phe Ser Ile 
225                 230                 235                 240 

Ile Leu Val Val Gly Tyr Tyr Phe Ile Ser Arg Glu Lys Glu Glu Gln 
                245                 250                 255     

Ala 
    

<210>   2813
<211>   825
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2813
atgcaatcga ggaggaaaga gatgaagaaa acaagctcta aactctttgt agtaccctac   60
atgctttgga ttgcgctctt tgtattggca cccttggtct tgattttcgg tcaatccttt   120
ttcaacatcg aaggccagtt cagtttagaa aattacaaat cttactttgc gtcacaaaac   180
ttgacctatc ttaaaatgag tttcaactca gtgctttatg caggcattgt gacctttgtg   240
gcactgctta tcagttatcc gacggccctc tttttgaccc gtctcaaaca ccgtcaactc   300
tggctcatgc tgattatcct tcctacctgg atcaatttgc tccttaaagc ctatgctttt   360
atcgggattt ttggtcaaaa tggctctatt aaccaattct tggaatttat cggaattggt   420
tcacaacagt tgctttttac cgatttttcc tttatctttg tcgcaagcta catcgagctc   480
ccctttatga ttttgccgat tttcaatgtc ttagacgata tggataataa tctcatcaat   540
gctagttatg accttggtgc aactaagtgg gagaccttcc gtcatgtcat cttccctcta   600
tctatgaacg gtgtgcgaag tggggttcag tcggtcttta tcccaagttt gagtctcttc   660
atgctgaccc gtttgattgg tgggaaccgc gttatcacct tggggacggc tattgagcag   720
aattttctaa ccaatgacaa ctatggtatg ggttcaacca tcggtgtgat tctcatcctg   780
accatgttca tcaccatgtg ggtgactaag gaaaggagag aacga                   825

<210>   2814
<211>   275
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spermidine/putrescine ABC transporter, permease protein (potH)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903288 (e-155)

<400>   2814
Met Gln Ser Arg Arg Lys Glu Met Lys Lys Thr Ser Ser Lys Leu Phe 
1               5                   10                  15      

Val Val Pro Tyr Met Leu Trp Ile Ala Leu Phe Val Leu Ala Pro Leu 
            20                  25                  30          

Val Leu Ile Phe Gly Gln Ser Phe Phe Asn Ile Glu Gly Gln Phe Ser 
        35                  40                  45              

Leu Glu Asn Tyr Lys Ser Tyr Phe Ala Ser Gln Asn Leu Thr Tyr Leu 
    50                  55                  60                  

Lys Met Ser Phe Asn Ser Val Leu Tyr Ala Gly Ile Val Thr Phe Val 
65                  70                  75                  80  

Ala Leu Leu Ile Ser Tyr Pro Thr Ala Leu Phe Leu Thr Arg Leu Lys 
                85                  90                  95      

His Arg Gln Leu Trp Leu Met Leu Ile Ile Leu Pro Thr Trp Ile Asn 
            100                 105                 110         

Leu Leu Leu Lys Ala Tyr Ala Phe Ile Gly Ile Phe Gly Gln Asn Gly 
        115                 120                 125             

Ser Ile Asn Gln Phe Leu Glu Phe Ile Gly Ile Gly Ser Gln Gln Leu 
    130                 135                 140                 

Leu Phe Thr Asp Phe Ser Phe Ile Phe Val Ala Ser Tyr Ile Glu Leu 
145                 150                 155                 160 

Pro Phe Met Ile Leu Pro Ile Phe Asn Val Leu Asp Asp Met Asp Asn 
                165                 170                 175     

Asn Leu Ile Asn Ala Ser Tyr Asp Leu Gly Ala Thr Lys Trp Glu Thr 
            180                 185                 190         

Phe Arg His Val Ile Phe Pro Leu Ser Met Asn Gly Val Arg Ser Gly 
        195                 200                 205             

Val Gln Ser Val Phe Ile Pro Ser Leu Ser Leu Phe Met Leu Thr Arg 
    210                 215                 220                 

Leu Ile Gly Gly Asn Arg Val Ile Thr Leu Gly Thr Ala Ile Glu Gln 
225                 230                 235                 240 

Asn Phe Leu Thr Asn Asp Asn Tyr Gly Met Gly Ser Thr Ile Gly Val 
                245                 250                 255     

Ile Leu Ile Leu Thr Met Phe Ile Thr Met Trp Val Thr Lys Glu Arg 
            260                 265                 270         

Arg Glu Arg 
        275 

<210>   2815
<211>   1155
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2815
ttgaaaaagc caattatcga attcaaaaac gtctctaaag tttttgaaga cagcaacacc   60
aaggttctca aagacatcaa ctttgagttg gaagaaggga aattctacac ccttctaggt   120
gcatctggtt cggggaaatc aactatccta aacattattg caggtttact ggatgcgacg   180
acaggagata tcatgctaga cggtgttcgt atcaatgata ttccaaccaa caagcgcgac   240
gtacataccg tcttccaatc ctatgccttg ttcccacata tgaatgtgtt tgaaaatgtt   300
gcctttccac ttcgcttgcg taaaattgat aagaaagaaa tcgagcagcg tgtagcggaa   360
gttctcaaga tggttcagtt ggaaggttat gaaaaacgtt ccatccgcaa actttctgga   420
ggacaacgtc agcgtgtggc catcgcccgt gctatcatca accaaccccg tgtggtcttg   480
ttggacgagc ctttatcagc gctggacttg aaattgagaa cagacatgca gtacgaattg   540
cgtgaattac aacaacgatt gggcattacc tttgtctttg tcactcacga tcaggaagaa   600
gctcttgcca tgagtgactg gattttcgtt atgaatgatg gcgagattgt ccagtctgga   660
acccctgtgg acatctacga tgagccaatc aaccactttg ttgccacctt tatcggggag   720
tcaaacatct tgccaggtac catgattgag gactacttgg tcgaatttaa cggcaaacgc   780
tttgaagcgg ttgatggtgg gatgaagcca aatgaacctg ttgaggtcgt tattcgtcca   840
gaggacttgc gcattaccct tcctgaagaa ggcaagctcc aagttaaggt cgatacccag   900
cttttccgtg gagttcatta tgaaattatc gcctatgacg aacttggaaa tgaatggatg   960
atccactcaa cccgtaaggc tatcgtgggt gaggaaatcg gtctggactt tgaaccagaa   1020
gacatccaca tcatgcgtct caatgaaacc gaagaagagt tcgatgctcg tattgaggag   1080
tacgtagaaa tcgaagagca agaagcaggt ttgatcaatg caatcgagga ggaaagagat   1140
gaagaaaaca agctc                                                    1155

<210>   2816
<211>   385
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spermidine/putrescine ABC transporter, ATP-binding protein (potA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903289 (0.E+01)

<400>   2816
Met Lys Lys Pro Ile Ile Glu Phe Lys Asn Val Ser Lys Val Phe Glu 
1               5                   10                  15      

Asp Ser Asn Thr Lys Val Leu Lys Asp Ile Asn Phe Glu Leu Glu Glu 
            20                  25                  30          

Gly Lys Phe Tyr Thr Leu Leu Gly Ala Ser Gly Ser Gly Lys Ser Thr 
        35                  40                  45              

Ile Leu Asn Ile Ile Ala Gly Leu Leu Asp Ala Thr Thr Gly Asp Ile 
    50                  55                  60                  

Met Leu Asp Gly Val Arg Ile Asn Asp Ile Pro Thr Asn Lys Arg Asp 
65                  70                  75                  80  

Val His Thr Val Phe Gln Ser Tyr Ala Leu Phe Pro His Met Asn Val 
                85                  90                  95      

Phe Glu Asn Val Ala Phe Pro Leu Arg Leu Arg Lys Ile Asp Lys Lys 
            100                 105                 110         

Glu Ile Glu Gln Arg Val Ala Glu Val Leu Lys Met Val Gln Leu Glu 
        115                 120                 125             

Gly Tyr Glu Lys Arg Ser Ile Arg Lys Leu Ser Gly Gly Gln Arg Gln 
    130                 135                 140                 

Arg Val Ala Ile Ala Arg Ala Ile Ile Asn Gln Pro Arg Val Val Leu 
145                 150                 155                 160 

Leu Asp Glu Pro Leu Ser Ala Leu Asp Leu Lys Leu Arg Thr Asp Met 
                165                 170                 175     

Gln Tyr Glu Leu Arg Glu Leu Gln Gln Arg Leu Gly Ile Thr Phe Val 
            180                 185                 190         

Phe Val Thr His Asp Gln Glu Glu Ala Leu Ala Met Ser Asp Trp Ile 
        195                 200                 205             

Phe Val Met Asn Asp Gly Glu Ile Val Gln Ser Gly Thr Pro Val Asp 
    210                 215                 220                 

Ile Tyr Asp Glu Pro Ile Asn His Phe Val Ala Thr Phe Ile Gly Glu 
225                 230                 235                 240 

Ser Asn Ile Leu Pro Gly Thr Met Ile Glu Asp Tyr Leu Val Glu Phe 
                245                 250                 255     

Asn Gly Lys Arg Phe Glu Ala Val Asp Gly Gly Met Lys Pro Asn Glu 
            260                 265                 270         

Pro Val Glu Val Val Ile Arg Pro Glu Asp Leu Arg Ile Thr Leu Pro 
        275                 280                 285             

Glu Glu Gly Lys Leu Gln Val Lys Val Asp Thr Gln Leu Phe Arg Gly 
    290                 295                 300                 

Val His Tyr Glu Ile Ile Ala Tyr Asp Glu Leu Gly Asn Glu Trp Met 
305                 310                 315                 320 

Ile His Ser Thr Arg Lys Ala Ile Val Gly Glu Glu Ile Gly Leu Asp 
                325                 330                 335     

Phe Glu Pro Glu Asp Ile His Ile Met Arg Leu Asn Glu Thr Glu Glu 
            340                 345                 350         

Glu Phe Asp Ala Arg Ile Glu Glu Tyr Val Glu Ile Glu Glu Gln Glu 
        355                 360                 365             

Ala Gly Leu Ile Asn Ala Ile Glu Glu Glu Arg Asp Glu Glu Asn Lys 
    370                 375                 380                 

Leu 
385 

<210>   2817
<211>   948
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2817
atgtctgtaa gagaaaaaat gcttgaaatc ttagaaggaa ttgatatccg ttttaaggaa   60
cccttgcata gctatagtta tacaaaagta ggtggagagg ctgattattt ggtctttcca   120
cgaaatcgtt ttgagttggc tcgcgttgtg aaatttgcca accaagaaaa tatcccttgg   180
atggttcttg gcaatgcaag caatatcatc gttcgtgatg gtgggattcg tggatttgtc   240
atcttgtgtg acaagctcaa taacgtttct gttgatggct ataccattga agcagaagct   300
ggggctaact tgattgaaac aactcgcatt gccctccgtc atagtttaac tggctttgag   360
tttgcttgtg gtattccagg aagcgttggc ggtgctgtct ttatgaatgc gggtgcctat   420
ggtggcgaga ttgctcacat cttgcagtct tgtaaggtct tgaccaagga tggagaaatc   480
gaaaccctgt ctgctaaaga cttggctttt ggttaccgtc attcagctat tcaggagtct   540
ggtgcagttg tcttgtcagt taaatttgcc ctagctccag gaacccatca ggttatcaag   600
caggaaatgg accgcttgac gcacctacgt gaactcaagc aacctttgga atacccatct   660
tgtggctcgg tctttaagcg tccagtcggg cattttgcag gtcagttaat ttcagaagct   720
ggcttgaaag gctatcgtat cggtggcgta gaagtgtcag aaaagcatgc aggatttatg   780
atcaatgtcg cagatggaac ggccaaagac tacgaggact tgatccaatc ggttatcgaa   840
aaagtcaagg aacactcagg tattacgctt gaaagagaag tccggatctt gggtgaaagc   900
ctatcggtag cgaagatgta tgcaggtggt tttactccct gcaagagg                948

<210>   2818
<211>   316
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylenolpyruvoylglucosamine reductase (murB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903290 (0.E+01)

<400>   2818
Met Ser Val Arg Glu Lys Met Leu Glu Ile Leu Glu Gly Ile Asp Ile 
1               5                   10                  15      

Arg Phe Lys Glu Pro Leu His Ser Tyr Ser Tyr Thr Lys Val Gly Gly 
            20                  25                  30          

Glu Ala Asp Tyr Leu Val Phe Pro Arg Asn Arg Phe Glu Leu Ala Arg 
        35                  40                  45              

Val Val Lys Phe Ala Asn Gln Glu Asn Ile Pro Trp Met Val Leu Gly 
    50                  55                  60                  

Asn Ala Ser Asn Ile Ile Val Arg Asp Gly Gly Ile Arg Gly Phe Val 
65                  70                  75                  80  

Ile Leu Cys Asp Lys Leu Asn Asn Val Ser Val Asp Gly Tyr Thr Ile 
                85                  90                  95      

Glu Ala Glu Ala Gly Ala Asn Leu Ile Glu Thr Thr Arg Ile Ala Leu 
            100                 105                 110         

Arg His Ser Leu Thr Gly Phe Glu Phe Ala Cys Gly Ile Pro Gly Ser 
        115                 120                 125             

Val Gly Gly Ala Val Phe Met Asn Ala Gly Ala Tyr Gly Gly Glu Ile 
    130                 135                 140                 

Ala His Ile Leu Gln Ser Cys Lys Val Leu Thr Lys Asp Gly Glu Ile 
145                 150                 155                 160 

Glu Thr Leu Ser Ala Lys Asp Leu Ala Phe Gly Tyr Arg His Ser Ala 
                165                 170                 175     

Ile Gln Glu Ser Gly Ala Val Val Leu Ser Val Lys Phe Ala Leu Ala 
            180                 185                 190         

Pro Gly Thr His Gln Val Ile Lys Gln Glu Met Asp Arg Leu Thr His 
        195                 200                 205             

Leu Arg Glu Leu Lys Gln Pro Leu Glu Tyr Pro Ser Cys Gly Ser Val 
    210                 215                 220                 

Phe Lys Arg Pro Val Gly His Phe Ala Gly Gln Leu Ile Ser Glu Ala 
225                 230                 235                 240 

Gly Leu Lys Gly Tyr Arg Ile Gly Gly Val Glu Val Ser Glu Lys His 
                245                 250                 255     

Ala Gly Phe Met Ile Asn Val Ala Asp Gly Thr Ala Lys Asp Tyr Glu 
            260                 265                 270         

Asp Leu Ile Gln Ser Val Ile Glu Lys Val Lys Glu His Ser Gly Ile 
        275                 280                 285             

Thr Leu Glu Arg Glu Val Arg Ile Leu Gly Glu Ser Leu Ser Val Ala 
    290                 295                 300                 

Lys Met Tyr Ala Gly Gly Phe Thr Pro Cys Lys Arg 
305                 310                 315     

<210>   2819
<211>   750
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2819
atgaccattc atatcattat taccatgttg ctgttgctag cttttctgat aggaagcatt   60
tggtttgcca aaaagaaata ccagattaat ctagctgtct tgggcttggg tgcagtcgct   120
ttctttgtct cttcgcagat tttggaaaaa ctggtgcata tcttgatttt gcaccctcaa   180
aaagacggta gtattgccct cttgcaagat catccgctta tctatattat ctatggccta   240
gccatggcag cattttttga ggaaacggct cgtcttgttt tcttcaaatg gttggagaaa   300
aagagaagtt tggaaaaggc agacgccttg gcctatggac tggggcatgg tggcttggag   360
ttgatttttc taggccttac tagtttactc aatctttaca ttgttctttc ggcagttcaa   420
actcagaatc cacaggttat gcaattactg tctgaaaata tgttaaaaac cattcagtca   480
ctttcggtct ggcagattta tttgcttggt tttgagcgaa tcttggcgct tggtttccaa   540
ttacttttga cagtttgggt ttaccaagct gttcgccaga agaaatggat ttatctccta   600
gcagcctatg gcttgcatgc cttctttgat ctggcaccat ctcttttcca agtaggctgg   660
ttgacaaatc cagtcttggt tgaagtgatt ctagcactgg agctcgttct ggtcgcctat   720
ggaaccaagg aaatcttttg taaaaaatca                                    750

<210>   2820
<211>   250
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903291 (e-138)

<400>   2820
Met Thr Ile His Ile Ile Ile Thr Met Leu Leu Leu Leu Ala Phe Leu 
1               5                   10                  15      

Ile Gly Ser Ile Trp Phe Ala Lys Lys Lys Tyr Gln Ile Asn Leu Ala 
            20                  25                  30          

Val Leu Gly Leu Gly Ala Val Ala Phe Phe Val Ser Ser Gln Ile Leu 
        35                  40                  45              

Glu Lys Leu Val His Ile Leu Ile Leu His Pro Gln Lys Asp Gly Ser 
    50                  55                  60                  

Ile Ala Leu Leu Gln Asp His Pro Leu Ile Tyr Ile Ile Tyr Gly Leu 
65                  70                  75                  80  

Ala Met Ala Ala Phe Phe Glu Glu Thr Ala Arg Leu Val Phe Phe Lys 
                85                  90                  95      

Trp Leu Glu Lys Lys Arg Ser Leu Glu Lys Ala Asp Ala Leu Ala Tyr 
            100                 105                 110         

Gly Leu Gly His Gly Gly Leu Glu Leu Ile Phe Leu Gly Leu Thr Ser 
        115                 120                 125             

Leu Leu Asn Leu Tyr Ile Val Leu Ser Ala Val Gln Thr Gln Asn Pro 
    130                 135                 140                 

Gln Val Met Gln Leu Leu Ser Glu Asn Met Leu Lys Thr Ile Gln Ser 
145                 150                 155                 160 

Leu Ser Val Trp Gln Ile Tyr Leu Leu Gly Phe Glu Arg Ile Leu Ala 
                165                 170                 175     

Leu Gly Phe Gln Leu Leu Leu Thr Val Trp Val Tyr Gln Ala Val Arg 
            180                 185                 190         

Gln Lys Lys Trp Ile Tyr Leu Leu Ala Ala Tyr Gly Leu His Ala Phe 
        195                 200                 205             

Phe Asp Leu Ala Pro Ser Leu Phe Gln Val Gly Trp Leu Thr Asn Pro 
    210                 215                 220                 

Val Leu Val Glu Val Ile Leu Ala Leu Glu Leu Val Leu Val Ala Tyr 
225                 230                 235                 240 

Gly Thr Lys Glu Ile Phe Cys Lys Lys Ser 
                245                 250 

<210>   2821
<211>   729
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2821
atggataaga acgtgcagga accagtgaaa ttatttcaat acaatactct tggagccttg   60

atggctggcc tttatggtgg tactatgaca gtaggagaat tgctagaaca tggtgacctt   120
ggtttgggaa ccttggattc cattgatggg gaattgattg tcttggatgg caaggcttat   180
caggccaaag ggtcaggaga ccagccagaa attgtggaag tgtcaccaga tgcccttatt   240
ccttacgctg cagtggtacc gcatcgggca gaggtcattt tccgccagcg ctttgagatg   300
acagacaagg aattgaaaga acgaattgag tcttattatg atggggaaaa tcttttccgc   360
tctatcaaga ttcgggggga atttttacat atgcatgtgc gtatgattcc taagtcaaca   420
cccgatacca agtttgctga tgtcgcaacc catcaaccgg aatatagtcg tgacaatgtt   480
gcggggacta ttgttggttt ctggacgcct gagattttcc atggggtcag tgtggcaggc   540
taccatctgc acttcatatc agatgatttg accttcggtg gacatgtcat ggattttgtc   600
atcaaggaag gcattatcga ggtgggagca gttgaccagt tggaccaacg tttcccagtc   660
caagaccgtc aatacttgtt tgctaagttc aatgttgacg agatgaaaaa agatattgaa   720
aaggcagaa                                                           729

<210>   2822
<211>   243
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alpha-acetolactate decarboxylase (aldB)
<223>   Similar to strain R6 sequence 15903292 (e-140)

<400>   2822
Met Asp Lys Asn Val Gln Glu Pro Val Lys Leu Phe Gln Tyr Asn Thr 
1               5                   10                  15      

Leu Gly Ala Leu Met Ala Gly Leu Tyr Gly Gly Thr Met Thr Val Gly 
            20                  25                  30          

Glu Leu Leu Glu His Gly Asp Leu Gly Leu Gly Thr Leu Asp Ser Ile 
        35                  40                  45              

Asp Gly Glu Leu Ile Val Leu Asp Gly Lys Ala Tyr Gln Ala Lys Gly 
    50                  55                  60                  

Ser Gly Asp Gln Pro Glu Ile Val Glu Val Ser Pro Asp Ala Leu Ile 
65                  70                  75                  80  

Pro Tyr Ala Ala Val Val Pro His Arg Ala Glu Val Ile Phe Arg Gln 
                85                  90                  95      

Arg Phe Glu Met Thr Asp Lys Glu Leu Lys Glu Arg Ile Glu Ser Tyr 
            100                 105                 110         

Tyr Asp Gly Glu Asn Leu Phe Arg Ser Ile Lys Ile Arg Gly Glu Phe 
        115                 120                 125             

Leu His Met His Val Arg Met Ile Pro Lys Ser Thr Pro Asp Thr Lys 
    130                 135                 140                 

Phe Ala Asp Val Ala Thr His Gln Pro Glu Tyr Ser Arg Asp Asn Val 
145                 150                 155                 160 

Ala Gly Thr Ile Val Gly Phe Trp Thr Pro Glu Ile Phe His Gly Val 
                165                 170                 175     

Ser Val Ala Gly Tyr His Leu His Phe Ile Ser Asp Asp Leu Thr Phe 
            180                 185                 190         

Gly Gly His Val Met Asp Phe Val Ile Lys Glu Gly Ile Ile Glu Val 
        195                 200                 205             

Gly Ala Val Asp Gln Leu Asp Gln Arg Phe Pro Val Gln Asp Arg Gln 
    210                 215                 220                 

Tyr Leu Phe Ala Lys Phe Asn Val Asp Glu Met Lys Lys Asp Ile Glu 
225                 230                 235                 240 

Lys Ala Glu 
            

<210>   2823
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2823
ttgcccctag atgtgaacga gagaaacgct ctagacattg ccaagaagga aaaaaaaggg   60
tacaatgtaa caaaatcaag ggaggtctgg aatgaagaaa caaagcaagt acaaagaggt   120
cgtttcctat ctgaaaaatg gtatcgagtc tggacgattt ccgacggg                168

<210>   2824
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein

<400>   2824
Met Pro Leu Asp Val Asn Glu Arg Asn Ala Leu Asp Ile Ala Lys Lys 
1               5                   10                  15      

Glu Lys Lys Gly Tyr Asn Val Thr Lys Ser Arg Glu Val Trp Asn Glu 
            20                  25                  30          

Glu Thr Lys Gln Val Gln Arg Gly Arg Phe Leu Ser Glu Lys Trp Tyr 
        35                  40                  45              

Arg Val Trp Thr Ile Ser Asp Gly 
    50                  55      

<210>   2825
<211>   1269
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2825
atgaagaaac aaagcaagta caaagaggtc gtttcctatc tgaaaaatgg tatcgagtct   60
ggacgatttc cgacgggtag tcgcctgcct tctatccgtc aactgagcct tgactttcac   120
tgcagcaagg acaccattca acgagccctg ctggaattac ggcacgaaca atacctctat   180
gccaagcctc agagtggcta ctatgtatta gaacaagggc aacatcaaga cctagaaatc   240
gaggttaccg acgaacatgc cagtgcctat gacgatttcc gactctgtgt caatgaaacc   300
ttgattggcc gagaaaacta cctcttcaac tactatgaca atcaagaagg attagaagac   360
ctaagacagt ccattcacaa actcctcttt gagcaagctc tctactgcaa ggctaaccaa   420
ctagtactga cttctggaac ccaacaagcc ttgtttatcc tctctcaaat atcctttcct   480
agacaagcca aggaaatctt ggtggaacag ccaacctacc atcggatgaa tcgcctcttg   540
attgcacagg ggctggacta tcaaacgatt gaacgaggca ttgatgggat tgacttggag   600
gagctggaag gccacttcaa aacaggaaaa attaagtttt tctacaccat tccccgattt   660
cactatcccc tgggacattc ctattctgag caagacaaac gatctattct taacttagct   720
gccaagtatg atgtctatat cgtagaggac gattatctgg gtgatttgga ctccaagaag   780
ggccaaacct tccactatct tgatacagag gagcgtgtca tttatatcaa gtccttctcg   840
accagccttt ttcctgccct tcgtattaca gcactcattc ttccaaatgc tatcaaagaa   900
gcatttgtgg cctacaaaaa tatcctagac tacgacagca acctcattat gcaaaaggcc   960
ctgtcactct atattgacag tcaattgttt gaaaaaaatc gtttggctcg cttgaccaat   1020
catgaatctt accaaaaaca aatcgaggaa aggataacta aaacaccttg tccccttcct   1080
cattattccc tacacgatgg tttattgcta gacctgagac agtatcctaa aatcgccagt   1140
ctcaaacaca gtcaactggg cttggacttc tttgaagagg cctatttaag cacctgtcct   1200
tatcaatttg ccaaggtgtc cctagacaat ctggaaaatg ttttaaacta tttaaaagca   1260
gaattggaa                                                           1269

<210>   2826
<211>   423
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903293 (0.E+01)

<400>   2826
Met Lys Lys Gln Ser Lys Tyr Lys Glu Val Val Ser Tyr Leu Lys Asn 
1               5                   10                  15      

Gly Ile Glu Ser Gly Arg Phe Pro Thr Gly Ser Arg Leu Pro Ser Ile 
            20                  25                  30          

Arg Gln Leu Ser Leu Asp Phe His Cys Ser Lys Asp Thr Ile Gln Arg 
        35                  40                  45              

Ala Leu Leu Glu Leu Arg His Glu Gln Tyr Leu Tyr Ala Lys Pro Gln 
    50                  55                  60                  

Ser Gly Tyr Tyr Val Leu Glu Gln Gly Gln His Gln Asp Leu Glu Ile 
65                  70                  75                  80  

Glu Val Thr Asp Glu His Ala Ser Ala Tyr Asp Asp Phe Arg Leu Cys 
                85                  90                  95      

Val Asn Glu Thr Leu Ile Gly Arg Glu Asn Tyr Leu Phe Asn Tyr Tyr 
            100                 105                 110         

Asp Asn Gln Glu Gly Leu Glu Asp Leu Arg Gln Ser Ile His Lys Leu 
        115                 120                 125             

Leu Phe Glu Gln Ala Leu Tyr Cys Lys Ala Asn Gln Leu Val Leu Thr 
    130                 135                 140                 

Ser Gly Thr Gln Gln Ala Leu Phe Ile Leu Ser Gln Ile Ser Phe Pro 
145                 150                 155                 160 

Arg Gln Ala Lys Glu Ile Leu Val Glu Gln Pro Thr Tyr His Arg Met 
                165                 170                 175     

Asn Arg Leu Leu Ile Ala Gln Gly Leu Asp Tyr Gln Thr Ile Glu Arg 
            180                 185                 190         

Gly Ile Asp Gly Ile Asp Leu Glu Glu Leu Glu Gly His Phe Lys Thr 
        195                 200                 205             

Gly Lys Ile Lys Phe Phe Tyr Thr Ile Pro Arg Phe His Tyr Pro Leu 
    210                 215                 220                 

Gly His Ser Tyr Ser Glu Gln Asp Lys Arg Ser Ile Leu Asn Leu Ala 
225                 230                 235                 240 

Ala Lys Tyr Asp Val Tyr Ile Val Glu Asp Asp Tyr Leu Gly Asp Leu 
                245                 250                 255     

Asp Ser Lys Lys Gly Gln Thr Phe His Tyr Leu Asp Thr Glu Glu Arg 
            260                 265                 270         

Val Ile Tyr Ile Lys Ser Phe Ser Thr Ser Leu Phe Pro Ala Leu Arg 
        275                 280                 285             

Ile Thr Ala Leu Ile Leu Pro Asn Ala Ile Lys Glu Ala Phe Val Ala 
    290                 295                 300                 

Tyr Lys Asn Ile Leu Asp Tyr Asp Ser Asn Leu Ile Met Gln Lys Ala 
305                 310                 315                 320 

Leu Ser Leu Tyr Ile Asp Ser Gln Leu Phe Glu Lys Asn Arg Leu Ala 
                325                 330                 335     

Arg Leu Thr Asn His Glu Ser Tyr Gln Lys Gln Ile Glu Glu Arg Ile 
            340                 345                 350         

Thr Lys Thr Pro Cys Pro Leu Pro His Tyr Ser Leu His Asp Gly Leu 
        355                 360                 365             

Leu Leu Asp Leu Arg Gln Tyr Pro Lys Ile Ala Ser Leu Lys His Ser 
    370                 375                 380                 

Gln Leu Gly Leu Asp Phe Phe Glu Glu Ala Tyr Leu Ser Thr Cys Pro 
385                 390                 395                 400 

Tyr Gln Phe Ala Lys Val Ser Leu Asp Asn Leu Glu Asn Val Leu Asn 
                405                 410                 415     

Tyr Leu Lys Ala Glu Leu Glu 
            420             

<210>   2827
<211>   813
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2827
atgaaatcaa aaaaatggat atttgtttta tgtaattttc ttgcaagttt cttcttagta   60
gcttgtcagt caggttctaa tggttctcag tctgctgtgg atgctatcaa acaaaaaggg   120
aaattagttg tggcaaccag tcctgactat gcaccctttg aatttcaatc attggttgat   180
ggaaagaacc aggtagtcgg tgcagacatc gacatggctc aggctatcgc tgatgaactt   240
ggggttaagt tggaaatctc aagcatgagt tttgacaatg ttttgaccag tcttcaaact   300
ggtaaggctg acctagcagt tgcaggaatt agtgctactg acgagagaaa agaagtcttt   360
gatttttcaa tcccatacta tgaaaacaag attagtttct tggttcgtaa ggctgatgtg   420
gaaaaataca aggatttaac tagcctagaa agtgctaata ttgcagccca aaaagggact   480
gttccagaat caatggtcaa ggaacaattg ccaaaagttc aattaacttc cctaactaat   540
atgggtgaag cagtcaatga attgcaggct ggaaaaatag atgctgttca tatggatgag   600
cctgttgcac ttagttatgc tgctaaaaac gctggcttag ctgtcgcaac tgtcagcttg   660
aagatgaagg acggcgacgc caatgccgtt gctcttagaa aaaatagtga tgatttgaaa   720
gaagtggtag acaaggtcgt ccaaaaactt aaggatgaag gaacttacca aagctatctt   780
gaaaaagcag caagtctaac tgaagttgaa gaa                                813

<210>   2828

<211>   271
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, amino acid-binding protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903294 (e-147)

<400>   2828
Met Lys Ser Lys Lys Trp Ile Phe Val Leu Cys Asn Phe Leu Ala Ser 
1               5                   10                  15      

Phe Phe Leu Val Ala Cys Gln Ser Gly Ser Asn Gly Ser Gln Ser Ala 
            20                  25                  30          

Val Asp Ala Ile Lys Gln Lys Gly Lys Leu Val Val Ala Thr Ser Pro 
        35                  40                  45              

Asp Tyr Ala Pro Phe Glu Phe Gln Ser Leu Val Asp Gly Lys Asn Gln 
    50                  55                  60                  

Val Val Gly Ala Asp Ile Asp Met Ala Gln Ala Ile Ala Asp Glu Leu 
65                  70                  75                  80  

Gly Val Lys Leu Glu Ile Ser Ser Met Ser Phe Asp Asn Val Leu Thr 
                85                  90                  95      

Ser Leu Gln Thr Gly Lys Ala Asp Leu Ala Val Ala Gly Ile Ser Ala 
            100                 105                 110         

Thr Asp Glu Arg Lys Glu Val Phe Asp Phe Ser Ile Pro Tyr Tyr Glu 
        115                 120                 125             

Asn Lys Ile Ser Phe Leu Val Arg Lys Ala Asp Val Glu Lys Tyr Lys 
    130                 135                 140                 

Asp Leu Thr Ser Leu Glu Ser Ala Asn Ile Ala Ala Gln Lys Gly Thr 
145                 150                 155                 160 

Val Pro Glu Ser Met Val Lys Glu Gln Leu Pro Lys Val Gln Leu Thr 
                165                 170                 175     

Ser Leu Thr Asn Met Gly Glu Ala Val Asn Glu Leu Gln Ala Gly Lys 
            180                 185                 190         

Ile Asp Ala Val His Met Asp Glu Pro Val Ala Leu Ser Tyr Ala Ala 
        195                 200                 205             

Lys Asn Ala Gly Leu Ala Val Ala Thr Val Ser Leu Lys Met Lys Asp 
    210                 215                 220                 

Gly Asp Ala Asn Ala Val Ala Leu Arg Lys Asn Ser Asp Asp Leu Lys 
225                 230                 235                 240 

Glu Val Val Asp Lys Val Val Gln Lys Leu Lys Asp Glu Gly Thr Tyr 
                245                 250                 255     

Gln Ser Tyr Leu Glu Lys Ala Ala Ser Leu Thr Glu Val Glu Glu 
            260                 265                 270     

<210>   2829
<211>   651
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2829
atgttacgat ctcaatttga agaagattta gagaaattac ataaccagtt ctacgctatg   60
ggacaagaag tgctctcaca aatcaatcgt acggtacgtg cttttgtcac gcatgaccgt   120
gacctggcaa aagaggtcat cgaagatgat gcagaagtaa atgaatacga agtgaaactg   180
gaaaagaaat catttgaaat gatcgcactc caacaaccag tctctcaaga tttgcgtaca   240
gtcttgactg tccttaaggc tgtatcagat gtggagcgta tgggggatca cgctgtagcc   300
attgcccagg caaccatccg tatgaagggg gaagagcgca ttccagctgt agaggaagaa   360
attaaaaaaa tgggacgtga agttaaaagc gttgtggaag cagcacttga tctttatctt   420
aatggttctg ttgacgacgc ataccgggtg gcctccatgg atgagcaaat taaccactat   480
tttgaaacta tccgtgacct tgcgactgaa gagattaaga aaaatccaga agccattgtt   540
acgggtcgtg attatttcca agttatttcc tacttggagc gtatcggtga ctatgctaaa   600
aatatctgtg aatgggttgt ctactttgaa acaggtaaga ttgtcgaact a            651

<210>   2830
<211>   217
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate transport system regulatory protein PhoU, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903295 (e-120)

<400>   2830
Met Leu Arg Ser Gln Phe Glu Glu Asp Leu Glu Lys Leu His Asn Gln 
1               5                   10                  15      

Phe Tyr Ala Met Gly Gln Glu Val Leu Ser Gln Ile Asn Arg Thr Val 
            20                  25                  30          

Arg Ala Phe Val Thr His Asp Arg Asp Leu Ala Lys Glu Val Ile Glu 
        35                  40                  45              

Asp Asp Ala Glu Val Asn Glu Tyr Glu Val Lys Leu Glu Lys Lys Ser 
    50                  55                  60                  

Phe Glu Met Ile Ala Leu Gln Gln Pro Val Ser Gln Asp Leu Arg Thr 
65                  70                  75                  80  

Val Leu Thr Val Leu Lys Ala Val Ser Asp Val Glu Arg Met Gly Asp 
                85                  90                  95      

His Ala Val Ala Ile Ala Gln Ala Thr Ile Arg Met Lys Gly Glu Glu 

            100                 105                 110         

Arg Ile Pro Ala Val Glu Glu Glu Ile Lys Lys Met Gly Arg Glu Val 
        115                 120                 125             

Lys Ser Val Val Glu Ala Ala Leu Asp Leu Tyr Leu Asn Gly Ser Val 
    130                 135                 140                 

Asp Asp Ala Tyr Arg Val Ala Ser Met Asp Glu Gln Ile Asn His Tyr 
145                 150                 155                 160 

Phe Glu Thr Ile Arg Asp Leu Ala Thr Glu Glu Ile Lys Lys Asn Pro 
                165                 170                 175     

Glu Ala Ile Val Thr Gly Arg Asp Tyr Phe Gln Val Ile Ser Tyr Leu 
            180                 185                 190         

Glu Arg Ile Gly Asp Tyr Ala Lys Asn Ile Cys Glu Trp Val Val Tyr 
        195                 200                 205             

Phe Glu Thr Gly Lys Ile Val Glu Leu 
    210                 215         

<210>   2831
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   2831
atgacagatg cgattttaca ggtatcagac ctgtccgttt attataataa aaagaaggct   60
ttgaatagtg tttccctatc tttccaacct aaggaaatta cagccttgat tggtccatct   120
ggatcaggga agtcaaccct cctcaagtct ctcaaccgca tgggagatct caatccagag   180
gtgaccacaa ctggatccgt ggtgtacaat ggtcacaaca tctacagtcc gcgtacagat   240
acggttgaat tacgtaagga aatcggaatg gttttccaac aacctaatcc tttccctatg   300
actatctatg agaatgttgt ctacgggctt cgtatcaatg gaattaagga taagcaggtt   360
ctggatgaag ccgtagaaaa agccttgcaa ggtgcctcta tctgggatga ggtcaaggat   420
cgtctatatg attcagctat tggattgtca ggtggtcaac agcagcgtgt ctgcgtggcc   480
cgtgtcttgg caactagtcc taaaatcatc ctcttggatg agccaacttc ggctttggat   540
ccgatttcag ctggtaaaat tgaggaaacc ttgtatggtc taaaagacaa gtacaccatg   600
cttctggtaa cccgttccat gcagcaagct tcacgtatct ctgataagac aggatttttc   660
ctagatggag atttgattga atttaatgat accaagcaga tgttccttga tccccaacac   720
aaggaaacgg aagactatat tacaggaaaa tttgga                             756

<210>   2832
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate ABC transporter, ATP-binding protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903296 (e-142)

<400>   2832
Met Thr Asp Ala Ile Leu Gln Val Ser Asp Leu Ser Val Tyr Tyr Asn 
1               5                   10                  15      

Lys Lys Lys Ala Leu Asn Ser Val Ser Leu Ser Phe Gln Pro Lys Glu 
            20                  25                  30          

Ile Thr Ala Leu Ile Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Leu 
        35                  40                  45              

Lys Ser Leu Asn Arg Met Gly Asp Leu Asn Pro Glu Val Thr Thr Thr 
    50                  55                  60                  

Gly Ser Val Val Tyr Asn Gly His Asn Ile Tyr Ser Pro Arg Thr Asp 
65                  70                  75                  80  

Thr Val Glu Leu Arg Lys Glu Ile Gly Met Val Phe Gln Gln Pro Asn 
                85                  90                  95      

Pro Phe Pro Met Thr Ile Tyr Glu Asn Val Val Tyr Gly Leu Arg Ile 
            100                 105                 110         

Asn Gly Ile Lys Asp Lys Gln Val Leu Asp Glu Ala Val Glu Lys Ala 
        115                 120                 125             

Leu Gln Gly Ala Ser Ile Trp Asp Glu Val Lys Asp Arg Leu Tyr Asp 
    130                 135                 140                 

Ser Ala Ile Gly Leu Ser Gly Gly Gln Gln Gln Arg Val Cys Val Ala 
145                 150                 155                 160 

Arg Val Leu Ala Thr Ser Pro Lys Ile Ile Leu Leu Asp Glu Pro Thr 
                165                 170                 175     

Ser Ala Leu Asp Pro Ile Ser Ala Gly Lys Ile Glu Glu Thr Leu Tyr 
            180                 185                 190         

Gly Leu Lys Asp Lys Tyr Thr Met Leu Leu Val Thr Arg Ser Met Gln 
        195                 200                 205             

Gln Ala Ser Arg Ile Ser Asp Lys Thr Gly Phe Phe Leu Asp Gly Asp 
    210                 215                 220                 

Leu Ile Glu Phe Asn Asp Thr Lys Gln Met Phe Leu Asp Pro Gln His 
225                 230                 235                 240 

Lys Glu Thr Glu Asp Tyr Ile Thr Gly Lys Phe Gly 
                245                 250         

<210>   2833
<211>   801
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2833
atgtcaacat ataactggga tgagaagcat atccttacct ttcctgaaga aaaagtagcc   60
ctttctacta aggatgtcca tgtttactat ggtaaaaatg aatccattaa ggggattgat   120
atgcaatttg aaagaaataa aattacagct ttgattggcc cgtcgggatc ggggaaatct   180
acctacttac gcagtctcaa tcgcatgaat gatactattg atattgctaa agtaactggg   240
cagattctct atcgtggaat tgatgtcaac cgtccagaaa tcaacgttta tgaaatgcgt   300
aaacacattg gaatggtttt tcaacgtccc aatccatttg ctaagtcaat ttaccgtaat   360
attacctttg cgcatgaacg tgctggagtt aaggataagc aagtcctaga tgaaatcgta   420
gaaacctccc ttcgtcaggc tgccctctgg gatcaggtta aagacgatct ccacaagtca   480
gccttgacct tatcaggtgg tcagcaacaa cgtctctgta tcgctcgtgc catctctgtt   540
aagccagata tcctcttaat ggatgagcca gcctcagcct tggatccgat tgcgaccatg   600
caactagaag agaccatgtt tgagctcaag aaaaacttta ccatcatcat tgtaacgcat   660
aatatgcagc aggctgctcg tgcaagtgac tatacaggct tcttttactt gggtgatttg   720
attgagtatg acaagactgc aactattttc caaaatgcca agctacagtc caccaatgac   780
tatgtatctg gtcactttgg t                                             801

<210>   2834
<211>   267
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate ABC transporter, ATP-binding protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903297 (e-153)

<400>   2834
Met Ser Thr Tyr Asn Trp Asp Glu Lys His Ile Leu Thr Phe Pro Glu 
1               5                   10                  15      

Glu Lys Val Ala Leu Ser Thr Lys Asp Val His Val Tyr Tyr Gly Lys 
            20                  25                  30          

Asn Glu Ser Ile Lys Gly Ile Asp Met Gln Phe Glu Arg Asn Lys Ile 
        35                  40                  45              

Thr Ala Leu Ile Gly Pro Ser Gly Ser Gly Lys Ser Thr Tyr Leu Arg 
    50                  55                  60                  

Ser Leu Asn Arg Met Asn Asp Thr Ile Asp Ile Ala Lys Val Thr Gly 
65                  70                  75                  80  

Gln Ile Leu Tyr Arg Gly Ile Asp Val Asn Arg Pro Glu Ile Asn Val 
                85                  90                  95      

Tyr Glu Met Arg Lys His Ile Gly Met Val Phe Gln Arg Pro Asn Pro 
            100                 105                 110         

Phe Ala Lys Ser Ile Tyr Arg Asn Ile Thr Phe Ala His Glu Arg Ala 
        115                 120                 125             

Gly Val Lys Asp Lys Gln Val Leu Asp Glu Ile Val Glu Thr Ser Leu 
    130                 135                 140                 

Arg Gln Ala Ala Leu Trp Asp Gln Val Lys Asp Asp Leu His Lys Ser 
145                 150                 155                 160 

Ala Leu Thr Leu Ser Gly Gly Gln Gln Gln Arg Leu Cys Ile Ala Arg 
                165                 170                 175     

Ala Ile Ser Val Lys Pro Asp Ile Leu Leu Met Asp Glu Pro Ala Ser 
            180                 185                 190         

Ala Leu Asp Pro Ile Ala Thr Met Gln Leu Glu Glu Thr Met Phe Glu 
        195                 200                 205             

Leu Lys Lys Asn Phe Thr Ile Ile Ile Val Thr His Asn Met Gln Gln 
    210                 215                 220                 

Ala Ala Arg Ala Ser Asp Tyr Thr Gly Phe Phe Tyr Leu Gly Asp Leu 
225                 230                 235                 240 

Ile Glu Tyr Asp Lys Thr Ala Thr Ile Phe Gln Asn Ala Lys Leu Gln 
                245                 250                 255     

Ser Thr Asn Asp Tyr Val Ser Gly His Phe Gly 
            260                 265         

<210>   2835
<211>   882
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2835
atgcgcgcta agaaattaga taaacttgca acagctgtcc tctatacgat tgctagcatc   60
attgtgacaa tcttggcttc cttgattctc tatatcttgg ttcggggctt gccccatatc   120
tcttggtctt tcttgactgg aaggtcttct gcttttcaag caggtggtgg gattggcatt   180
cagctttaca attccttttt cctattggtc attaccttga ttatttctgt acctctttct   240
atgggagctg ggatttactt ggctgaatat gctaaaaaag gtcctgttac caactttgtg   300
cggacttgta ttgaaatttt gtcctcttta ccatcagtgg tggtgggtct ctttggttac   360
ttgatctttg tagtccagtt tgagtatgga ttttcaatca tttcaggtgc cttggccttg   420
acagtcttta acttgcctca gatgacgcgt aatgtagagg atagtttgaa acacgttcac   480
catacccaac gtgaggctgg tctggctctt gggatttctc gctgggagac agtggttcat   540
gttgttattc cggaagcgct tccaggtatt gtaacgggtg tcgtcttggc atctggtcgt   600
atctttggcg aagctgcagc tctgatctat acagcagggc aatcggcgcc agctcttgac   660
tggtctaact ggaatatcct cagtgtgact agccccatct ctatcttccg tcaagcagaa   720
accttggctg tccatatctg gaaagtcaat agtgaaggca ctattccaga tggaaccatt   780
gtatcagcag gttctgccgc tgtgctcctg atctttatcc tgatttttaa ctttggagct   840
cgtaagttcg gaagctatct acacaagaaa ttaaccgctg cc                      882

<210>   2836
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate ABC transporter, permease protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903298 (e-164)

<400>   2836
Met Arg Ala Lys Lys Leu Asp Lys Leu Ala Thr Ala Val Leu Tyr Thr 
1               5                   10                  15      

Ile Ala Ser Ile Ile Val Thr Ile Leu Ala Ser Leu Ile Leu Tyr Ile 
            20                  25                  30          

Leu Val Arg Gly Leu Pro His Ile Ser Trp Ser Phe Leu Thr Gly Arg 
        35                  40                  45              

Ser Ser Ala Phe Gln Ala Gly Gly Gly Ile Gly Ile Gln Leu Tyr Asn 
    50                  55                  60                  

Ser Phe Phe Leu Leu Val Ile Thr Leu Ile Ile Ser Val Pro Leu Ser 
65                  70                  75                  80  

Met Gly Ala Gly Ile Tyr Leu Ala Glu Tyr Ala Lys Lys Gly Pro Val 
                85                  90                  95      

Thr Asn Phe Val Arg Thr Cys Ile Glu Ile Leu Ser Ser Leu Pro Ser 
            100                 105                 110         

Val Val Val Gly Leu Phe Gly Tyr Leu Ile Phe Val Val Gln Phe Glu 
        115                 120                 125             

Tyr Gly Phe Ser Ile Ile Ser Gly Ala Leu Ala Leu Thr Val Phe Asn 
    130                 135                 140                 

Leu Pro Gln Met Thr Arg Asn Val Glu Asp Ser Leu Lys His Val His 
145                 150                 155                 160 

His Thr Gln Arg Glu Ala Gly Leu Ala Leu Gly Ile Ser Arg Trp Glu 
                165                 170                 175     

Thr Val Val His Val Val Ile Pro Glu Ala Leu Pro Gly Ile Val Thr 
            180                 185                 190         

Gly Val Val Leu Ala Ser Gly Arg Ile Phe Gly Glu Ala Ala Ala Leu 
        195                 200                 205             

Ile Tyr Thr Ala Gly Gln Ser Ala Pro Ala Leu Asp Trp Ser Asn Trp 
    210                 215                 220                 

Asn Ile Leu Ser Val Thr Ser Pro Ile Ser Ile Phe Arg Gln Ala Glu 
225                 230                 235                 240 

Thr Leu Ala Val His Ile Trp Lys Val Asn Ser Glu Gly Thr Ile Pro 
                245                 250                 255     

Asp Gly Thr Ile Val Ser Ala Gly Ser Ala Ala Val Leu Leu Ile Phe 
            260                 265                 270         

Ile Leu Ile Phe Asn Phe Gly Ala Arg Lys Phe Gly Ser Tyr Leu His 
        275                 280                 285             

Lys Lys Leu Thr Ala Ala 
    290                 

<210>   2837
<211>   915
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2837
atgaatcaag aagaattagc taagaaaatg ttgcttccat caaagaattc tcgtctggag   60
aaattaggaa aaggtttgac ctttgcctgt ctttctttga tagtcatcct tgtggccatg   120
attttggttt tcgtagcgca aaaaggcttg tcgaccttct ttgtcaatgg tgtgaatatc   180
tttgactttc ttttgggagg aacttggaat ccttctagta aagaatttgg tgcccttcct   240
atgattttgg gttcctttat cgttaccatt ctctcagccc ttatcgcaac accctttgct   300
attggtgcag cagtttttat gaccgaagta tcaccaaaag gggcgaagat tttgcaacca   360
gctattgaac tcctggttgg gattccttca gtagtgtacg gatttattgg cttgcaagtc   420
gtcgttccct ttgttcgcag tgtctttggt gggactggtt ttgggatttt gtcagggatt   480
tccgtcctct ttgtcatgat tttgccgacc gtaaccttta tgacaacgga tagcttgcgt   540
gcggttcctc gttattatcg tgaagccagt ttcgctatgg gagccactcg ctggcagact   600
atctggcgtg tgatcttgaa ggcggcccgt tctggtattt tcactgcagt ggtctttggg   660
atggcgcgtg cctttggtga ggctctagct atccagatgg ttgtcggaaa ctcagctgtt   720
atcccaactt ccttgaccac accagctgca actttaactt ctatattaac tatgggaatt   780
gggaacactg tcatgggaac tgtaaataat aatgttctct ggtcactggc cttggtactg   840
ctcttgatga gcttagtttt taacagtgtg attaaattga ttacgaaaga aagaggaaag   900
aaaaattatg cgcgc                                                    915

<210>   2838
<211>   305
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate ABC transporter, permease protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903299 (e-168)

<400>   2838
Met Asn Gln Glu Glu Leu Ala Lys Lys Met Leu Leu Pro Ser Lys Asn 
1               5                   10                  15      

Ser Arg Leu Glu Lys Leu Gly Lys Gly Leu Thr Phe Ala Cys Leu Ser 
            20                  25                  30          

Leu Ile Val Ile Leu Val Ala Met Ile Leu Val Phe Val Ala Gln Lys 
        35                  40                  45              

Gly Leu Ser Thr Phe Phe Val Asn Gly Val Asn Ile Phe Asp Phe Leu 
    50                  55                  60                  

Leu Gly Gly Thr Trp Asn Pro Ser Ser Lys Glu Phe Gly Ala Leu Pro 
65                  70                  75                  80  

Met Ile Leu Gly Ser Phe Ile Val Thr Ile Leu Ser Ala Leu Ile Ala 
                85                  90                  95      

Thr Pro Phe Ala Ile Gly Ala Ala Val Phe Met Thr Glu Val Ser Pro 
            100                 105                 110         

Lys Gly Ala Lys Ile Leu Gln Pro Ala Ile Glu Leu Leu Val Gly Ile 
        115                 120                 125             

Pro Ser Val Val Tyr Gly Phe Ile Gly Leu Gln Val Val Val Pro Phe 
    130                 135                 140                 

Val Arg Ser Val Phe Gly Gly Thr Gly Phe Gly Ile Leu Ser Gly Ile 
145                 150                 155                 160 

Ser Val Leu Phe Val Met Ile Leu Pro Thr Val Thr Phe Met Thr Thr 
                165                 170                 175     

Asp Ser Leu Arg Ala Val Pro Arg Tyr Tyr Arg Glu Ala Ser Phe Ala 
            180                 185                 190         

Met Gly Ala Thr Arg Trp Gln Thr Ile Trp Arg Val Ile Leu Lys Ala 
        195                 200                 205             

Ala Arg Ser Gly Ile Phe Thr Ala Val Val Phe Gly Met Ala Arg Ala 
    210                 215                 220                 

Phe Gly Glu Ala Leu Ala Ile Gln Met Val Val Gly Asn Ser Ala Val 
225                 230                 235                 240 

Ile Pro Thr Ser Leu Thr Thr Pro Ala Ala Thr Leu Thr Ser Ile Leu 
                245                 250                 255     

Thr Met Gly Ile Gly Asn Thr Val Met Gly Thr Val Asn Asn Asn Val 
            260                 265                 270         

Leu Trp Ser Leu Ala Leu Val Leu Leu Leu Met Ser Leu Val Phe Asn 
        275                 280                 285             

Ser Val Ile Lys Leu Ile Thr Lys Glu Arg Gly Lys Lys Asn Tyr Ala 
    290                 295                 300                 

Arg 
305 

<210>   2839
<211>   876
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2839
gtgaaaaaaa gaaaaaagct tgctctgtct cttatcgctt tttggctgac ggcttgttta   60
gtaggctgtg ctagctggat tgatcgtgga gaatccataa cggctgttgg ctcaactgcc   120
ttgcaaccct tggttgaagt agcggcagat gaatttggca cgatccatgt tggaaaaacg   180
gtcaatgtcc aagggggagg ttctggtaca ggcttgtccc aggttcagtc tggggcagtt   240
gatataggaa actcagatgt atttgctgag gaaaaagacg gaattgatgc ttctgctctt   300
gttgaccaca aggtcgcggt agctggcttg gctctgattg tcaataagga ggttgatgtt   360
gataacctaa cgacagagca acttcgtcaa atcttcatag gtgaggtaac caattggaaa   420
gaggttggtg gtaaggactt acccatctct gttatcaatc gggcagccgg ctctggctct   480
cgtgctacct ttgatactgt cattatggaa ggtcagtctg ccatgcaaag tcaggagcag   540
gattcaaatg gagcggtaaa atcaatcgta tcaaaaagtc caggagctat ctcttattta   600
tctcttacct atatagatga ttcggtcaaa agcatgaagt tgaatggcta tgacttaagt   660
ccagaaaata taagtagcaa taattggccc ttgtggtctt atgagcatat gtatacattg   720
gggcagccca atgagttggc tgcagaattt ctcaattttg ttctctcgga tgagacccaa   780
gaagggattg tcaaaggatt gaagtatatt ccgattaagg aaatgaaggt tgaaaaagat   840
gctgccggaa ctgtgacagt gttggaaggg agacaa                             876

<210>   2840
<211>   292
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate ABC transporter, phosphate-binding protein, putative
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903300 (e-165)

<400>   2840
Met Lys Lys Arg Lys Lys Leu Ala Leu Ser Leu Ile Ala Phe Trp Leu 
1               5                   10                  15      

Thr Ala Cys Leu Val Gly Cys Ala Ser Trp Ile Asp Arg Gly Glu Ser 
            20                  25                  30          

Ile Thr Ala Val Gly Ser Thr Ala Leu Gln Pro Leu Val Glu Val Ala 
        35                  40                  45              

Ala Asp Glu Phe Gly Thr Ile His Val Gly Lys Thr Val Asn Val Gln 
    50                  55                  60                  

Gly Gly Gly Ser Gly Thr Gly Leu Ser Gln Val Gln Ser Gly Ala Val 
65                  70                  75                  80  

Asp Ile Gly Asn Ser Asp Val Phe Ala Glu Glu Lys Asp Gly Ile Asp 
                85                  90                  95      

Ala Ser Ala Leu Val Asp His Lys Val Ala Val Ala Gly Leu Ala Leu 
            100                 105                 110         

Ile Val Asn Lys Glu Val Asp Val Asp Asn Leu Thr Thr Glu Gln Leu 
        115                 120                 125             

Arg Gln Ile Phe Ile Gly Glu Val Thr Asn Trp Lys Glu Val Gly Gly 
    130                 135                 140                 

Lys Asp Leu Pro Ile Ser Val Ile Asn Arg Ala Ala Gly Ser Gly Ser 
145                 150                 155                 160 

Arg Ala Thr Phe Asp Thr Val Ile Met Glu Gly Gln Ser Ala Met Gln 
                165                 170                 175     

Ser Gln Glu Gln Asp Ser Asn Gly Ala Val Lys Ser Ile Val Ser Lys 
            180                 185                 190         

Ser Pro Gly Ala Ile Ser Tyr Leu Ser Leu Thr Tyr Ile Asp Asp Ser 
        195                 200                 205             

Val Lys Ser Met Lys Leu Asn Gly Tyr Asp Leu Ser Pro Glu Asn Ile 
    210                 215                 220                 

Ser Ser Asn Asn Trp Pro Leu Trp Ser Tyr Glu His Met Tyr Thr Leu 
225                 230                 235                 240 

Gly Gln Pro Asn Glu Leu Ala Ala Glu Phe Leu Asn Phe Val Leu Ser 
                245                 250                 255     

Asp Glu Thr Gln Glu Gly Ile Val Lys Gly Leu Lys Tyr Ile Pro Ile 
            260                 265                 270         

Lys Glu Met Lys Val Glu Lys Asp Ala Ala Gly Thr Val Thr Val Leu 
        275                 280                 285             

Glu Gly Arg Gln 
    290         

<210>   2841
<211>   189
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2841
gtggataaaa tctcttgtct atcccttccc ccattgtcac ccattatagt catttcgtgt   60
ctctttttcc cctttttaat gcaagggaaa ttactctcct tagatgataa tccaaaagct   120
agaaaggtat ctcaaacctc tctactctcc cagactagtt tacaactaaa aggaaaagat   180
tctatttta                                                           189

<210>   2842
<211>   63
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   2842
Met Asp Lys Ile Ser Cys Leu Ser Leu Pro Pro Leu Ser Pro Ile Ile 
1               5                   10                  15      

Val Ile Ser Cys Leu Phe Phe Pro Phe Leu Met Gln Gly Lys Leu Leu 
            20                  25                  30          

Ser Leu Asp Asp Asn Pro Lys Ala Arg Lys Val Ser Gln Thr Ser Leu 
        35                  40                  45              

Leu Ser Gln Thr Ser Leu Gln Leu Lys Gly Lys Asp Ser Ile Leu 
    50                  55                  60              

<210>   2843
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2843
atgaaaatca aagagcaaac taggaagcta gccatagata gctcaaaaca ctggtttgaa   60
gagattttca aagagtacaa gaagtttagt tat                                93

<210>   2844
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   2844
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ile Asp Ser Ser Lys 
1               5                   10                  15      

His Trp Phe Glu Glu Ile Phe Lys Glu Tyr Lys Lys Phe Ser Tyr 
            20                  25                  30      

<210>   2845
<211>   1302
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2845
atgcaatttc cagaaggatt tgttgaaaaa tataaagaga tactaggaga tgaggcaaga   60
gattttcttg cctcttttga ggaggaagcg gtttcggcct ttcgggtcaa tcccttaaaa   120
gaagagcaac tttccttttc tgatgccatt actcaaaccc cttggggcca ctatgggaag   180
gtttcaggga aatcgcctga gcatgctaca ggtttagttt attcgcaaga acctgctgct   240
caaatggtgg ctcaagtagc ccaacccagt cctggtatga aggtcttgga cttggctgct   300
gcaccggggg gcaaatcaac tcaactggca gcctatctag caggggaggg gctacttgtt   360
tccaatgaaa tttcaagcaa acgggctaag attttggttg aaaacatgga gcgttttgga   420
gcgacaaatg tcgtggtgac caatgaatct gccgaccgct tggtcaaggt ctttaaaggc   480
tattttgact taatcgttct tgatgcccct tgctctggtg aaggaatgtt tcgtaagcaa   540
cctgatgcta tggactattg gagcttagat tatccgagtc aatgtgctag cttgcaaaga   600
gaaattctgg aggatgcagt gaccatgtta gctgaaggtg gtcatctggt ttattcgacc   660
tgtacctggg cacccgagga aaacgaagag attgtcaatt ggttgctgga agagtatgat   720
tttgacttgt tgccagtaga gcatatcaat ggaatggtag ctggtattga cctgccagaa   780
acggctcgga tgtatcctca tcagtttaag ggagagggtc agtttgttgc ccatctacag   840
tttaagggta acaatccagc tcctaaattt aaggcaagta agagtaacct cagccgtgaa   900
caagttgcct tgtggcagga atttgcccaa aaccatttga aggtcaatct accgggtatc   960
ttgcagattt ttggagacca gctttatctc ttgccagaac ttttgccaga tttatggaag   1020
ctcaagattg ctcgcaatgg actgcatctg ggtactttta agaagaaacg ctttgagccc   1080
agtttcgctc ttggtttagc cttgaaaccg agtcaggtcg aacagtcggt tgaaattggc   1140
caagaagcgt ttgtcaagta tgcggctgga gaaaccgttc agctggcaga aagtctgcca   1200
aatggttggt accaagtttt ggttaaaggc aatggcttgg gctttgcaaa ggttactgga   1260
aatgttttga aaaattattt tccaaaaggc ctcagattca aa                      1302

<210>   2846
<211>   434
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   NOL1/NOP2/sun family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903302 (e-153)

<400>   2846
Met Gln Phe Pro Glu Gly Phe Val Glu Lys Tyr Lys Glu Ile Leu Gly 
1               5                   10                  15      

Asp Glu Ala Arg Asp Phe Leu Ala Ser Phe Glu Glu Glu Ala Val Ser 
            20                  25                  30          

Ala Phe Arg Val Asn Pro Leu Lys Glu Glu Gln Leu Ser Phe Ser Asp 
        35                  40                  45              

Ala Ile Thr Gln Thr Pro Trp Gly His Tyr Gly Lys Val Ser Gly Lys 
    50                  55                  60                  

Ser Pro Glu His Ala Thr Gly Leu Val Tyr Ser Gln Glu Pro Ala Ala 
65                  70                  75                  80  

Gln Met Val Ala Gln Val Ala Gln Pro Ser Pro Gly Met Lys Val Leu 
                85                  90                  95      

Asp Leu Ala Ala Ala Pro Gly Gly Lys Ser Thr Gln Leu Ala Ala Tyr 
            100                 105                 110         

Leu Ala Gly Glu Gly Leu Leu Val Ser Asn Glu Ile Ser Ser Lys Arg 
        115                 120                 125             

Ala Lys Ile Leu Val Glu Asn Met Glu Arg Phe Gly Ala Thr Asn Val 
    130                 135                 140                 

Val Val Thr Asn Glu Ser Ala Asp Arg Leu Val Lys Val Phe Lys Gly 
145                 150                 155                 160 

Tyr Phe Asp Leu Ile Val Leu Asp Ala Pro Cys Ser Gly Glu Gly Met 
                165                 170                 175     

Phe Arg Lys Gln Pro Asp Ala Met Asp Tyr Trp Ser Leu Asp Tyr Pro 
            180                 185                 190         

Ser Gln Cys Ala Ser Leu Gln Arg Glu Ile Leu Glu Asp Ala Val Thr 
        195                 200                 205             

Met Leu Ala Glu Gly Gly His Leu Val Tyr Ser Thr Cys Thr Trp Ala 
    210                 215                 220                 

Pro Glu Glu Asn Glu Glu Ile Val Asn Trp Leu Leu Glu Glu Tyr Asp 
225                 230                 235                 240 

Phe Asp Leu Leu Pro Val Glu His Ile Asn Gly Met Val Ala Gly Ile 
                245                 250                 255     

Asp Leu Pro Glu Thr Ala Arg Met Tyr Pro His Gln Phe Lys Gly Glu 
            260                 265                 270         

Gly Gln Phe Val Ala His Leu Gln Phe Lys Gly Asn Asn Pro Ala Pro 
        275                 280                 285             

Lys Phe Lys Ala Ser Lys Ser Asn Leu Ser Arg Glu Gln Val Ala Leu 
    290                 295                 300                 

Trp Gln Glu Phe Ala Gln Asn His Leu Lys Val Asn Leu Pro Gly Ile 
305                 310                 315                 320 

Leu Gln Ile Phe Gly Asp Gln Leu Tyr Leu Leu Pro Glu Leu Leu Pro 
                325                 330                 335     

Asp Leu Trp Lys Leu Lys Ile Ala Arg Asn Gly Leu His Leu Gly Thr 
            340                 345                 350         

Phe Lys Lys Lys Arg Phe Glu Pro Ser Phe Ala Leu Gly Leu Ala Leu 
        355                 360                 365             

Lys Pro Ser Gln Val Glu Gln Ser Val Glu Ile Gly Gln Glu Ala Phe 
    370                 375                 380                 

Val Lys Tyr Ala Ala Gly Glu Thr Val Gln Leu Ala Glu Ser Leu Pro 
385                 390                 395                 400 

Asn Gly Trp Tyr Gln Val Leu Val Lys Gly Asn Gly Leu Gly Phe Ala 
                405                 410                 415     

Lys Val Thr Gly Asn Val Leu Lys Asn Tyr Phe Pro Lys Gly Leu Arg 
            420                 425                 430         

Phe Lys 
        

<210>   2847
<211>   771
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2847
ttggaaagta aatttgaatt tgctaaagag cttgttaaga aagcaggtca gtacattctt   60
gaccatatgc aggaagactt gcgtgttgaa accaagtcct ctccaacaga tttggtgacc   120
agactggaca aagaagttca ggaactcttg gttggtgaga ttttgtcccg ttatcctgag   180
gataagattt gtgctgaaga aggttgtctg cgagcctcgg ttcaagaggg caaggtttgg   240
gtcattgatc ccattgatgg taccaataat tttgtagccc agcaggaaga ttttgctgtt   300
atgatggctt attttgaaaa tggtcaggga cagtttggtc tgatttatga tgtggtcaaa   360
ggggattgtt accacggtgg tggggaattt ccagtttgtc taaatgatag gtccctagct   420
ccttttaaaa ctaaaccact tggagatttt ctcattgcag ggaatagtgg tatgctggaa   480
accaatgaat gggggctggc tgatttgagc cgagcggttc ttggtgttcg tgtctatgga   540
agtgcggcca ttagttttgc caagattttg tcagggcgtt tgttgaccta tctcacttat   600
ctgcaaccat gggattatgc cgcagctagt attttagggg aaagtctggg ctatcgggtt   660
gtgacccttt ttggtgaagc tcctgatttt caaaccagac agccggtcat gatggtgcct   720
cttgagatgc aggaggaaat tcagtcctat atttacgaaa ggaaaagaac t            771

<210>   2848
<211>   257
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   inositol monophosphatase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903303 (e-146)

<400>   2848
Met Glu Ser Lys Phe Glu Phe Ala Lys Glu Leu Val Lys Lys Ala Gly 
1               5                   10                  15      

Gln Tyr Ile Leu Asp His Met Gln Glu Asp Leu Arg Val Glu Thr Lys 
            20                  25                  30          

Ser Ser Pro Thr Asp Leu Val Thr Arg Leu Asp Lys Glu Val Gln Glu 
        35                  40                  45              

Leu Leu Val Gly Glu Ile Leu Ser Arg Tyr Pro Glu Asp Lys Ile Cys 
    50                  55                  60                  

Ala Glu Glu Gly Cys Leu Arg Ala Ser Val Gln Glu Gly Lys Val Trp 
65                  70                  75                  80  

Val Ile Asp Pro Ile Asp Gly Thr Asn Asn Phe Val Ala Gln Gln Glu 
                85                  90                  95      

Asp Phe Ala Val Met Met Ala Tyr Phe Glu Asn Gly Gln Gly Gln Phe 
            100                 105                 110         

Gly Leu Ile Tyr Asp Val Val Lys Gly Asp Cys Tyr His Gly Gly Gly 
        115                 120                 125             

Glu Phe Pro Val Cys Leu Asn Asp Arg Ser Leu Ala Pro Phe Lys Thr 
    130                 135                 140                 

Lys Pro Leu Gly Asp Phe Leu Ile Ala Gly Asn Ser Gly Met Leu Glu 
145                 150                 155                 160 

Thr Asn Glu Trp Gly Leu Ala Asp Leu Ser Arg Ala Val Leu Gly Val 
                165                 170                 175     

Arg Val Tyr Gly Ser Ala Ala Ile Ser Phe Ala Lys Ile Leu Ser Gly 
            180                 185                 190         

Arg Leu Leu Thr Tyr Leu Thr Tyr Leu Gln Pro Trp Asp Tyr Ala Ala 
        195                 200                 205             

Ala Ser Ile Leu Gly Glu Ser Leu Gly Tyr Arg Val Val Thr Leu Phe 
    210                 215                 220                 

Gly Glu Ala Pro Asp Phe Gln Thr Arg Gln Pro Val Met Met Val Pro 
225                 230                 235                 240 

Leu Glu Met Gln Glu Glu Ile Gln Ser Tyr Ile Tyr Glu Arg Lys Arg 
                245                 250                 255     

Thr 
    

<210>   2849
<211>   276
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2849
atgaacaaac agtatagtta cccactagat ttgtcgtgga gcactgaaga acttgcttca   60
gtgctttctt tttttaatga tgttgaagct gcctatgaag gcaaagtaga ggctaaaaag   120
ttactggact cctataaggg attcaaagcg gtcgtgccaa gcaagagcga agagaaacgt   180
ttgggacgag aatttgaaac ggttagtggc tattcacttt accgagcagt tcaggctgcc   240
aaagaaaaag gggaaggaaa gatttctctt ggaaag                             276

<210>   2850
<211>   92
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903304 (3.E-48)

<400>   2850
Met Asn Lys Gln Tyr Ser Tyr Pro Leu Asp Leu Ser Trp Ser Thr Glu 
1               5                   10                  15      

Glu Leu Ala Ser Val Leu Ser Phe Phe Asn Asp Val Glu Ala Ala Tyr 
            20                  25                  30          

Glu Gly Lys Val Glu Ala Lys Lys Leu Leu Asp Ser Tyr Lys Gly Phe 
        35                  40                  45              

Lys Ala Val Val Pro Ser Lys Ser Glu Glu Lys Arg Leu Gly Arg Glu 
    50                  55                  60                  

Phe Glu Thr Val Ser Gly Tyr Ser Leu Tyr Arg Ala Val Gln Ala Ala 
65                  70                  75                  80  

Lys Glu Lys Gly Glu Gly Lys Ile Ser Leu Gly Lys 
                85                  90          

<210>   2851
<211>   399
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2851
atgattacac tatttctatc accgagctgt acatcatgtc gtaaggctaa ggcctggtta   60
gaaaaacata aggttccctt tgtggaacac aatattatga ccagtccttt aacaagaaaa   120
gaattgcaac acatcctttc cttgaccgaa aatggtactg atgacatcat ttcaactcgt   180
tcaaaaattt ttcaaaaatt gaatattgat gtagagagta tttcggtatc ggaattgctt   240
catttgattg agcagtatcc tagtcttttg cgtcgtccaa ttattattga tgccaagcgt   300
atgcaaatcg gttttaatga agatgagatt cgtgcttttc tccctcgtag ttatcgtaag   360
caagaactaa aagaagcaag aatgagagct ggtattagt                          399

<210>   2852
<211>   133
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903305 (3.E-72)

<400>   2852
Met Ile Thr Leu Phe Leu Ser Pro Ser Cys Thr Ser Cys Arg Lys Ala 
1               5                   10                  15      

Lys Ala Trp Leu Glu Lys His Lys Val Pro Phe Val Glu His Asn Ile 
            20                  25                  30          

Met Thr Ser Pro Leu Thr Arg Lys Glu Leu Gln His Ile Leu Ser Leu 
        35                  40                  45              

Thr Glu Asn Gly Thr Asp Asp Ile Ile Ser Thr Arg Ser Lys Ile Phe 
    50                  55                  60                  

Gln Lys Leu Asn Ile Asp Val Glu Ser Ile Ser Val Ser Glu Leu Leu 
65                  70                  75                  80  

His Leu Ile Glu Gln Tyr Pro Ser Leu Leu Arg Arg Pro Ile Ile Ile 
                85                  90                  95      

Asp Ala Lys Arg Met Gln Ile Gly Phe Asn Glu Asp Glu Ile Arg Ala 
            100                 105                 110         

Phe Leu Pro Arg Ser Tyr Arg Lys Gln Glu Leu Lys Glu Ala Arg Met 
        115                 120                 125             

Arg Ala Gly Ile Ser 
    130             

<210>   2853
<211>   615
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2853
atgaaaacta aattgatctt ttggggctct atgctctttc tcctctccct ctccatcctt   60
ctgaccattt atctggcttg gattttctat cctatggaga ttcagtggct aaacttaacg   120
aatcgagtct atctaaaacc agaaaccatt caatacaatt ttcatatctt gatgaattat   180
ctgaccaatc cttttagtca ggtcttacag atgcctgatt ttcgttcgtc agcagctggt   240
ctgcaccatt tcgcagtggt caagaatctc tttcatttgg ttcagctagt agctctagtg   300
acactgccaa gtttctatgt ctttgtcaat aggattgtga aaaaggactt tttgtctctt   360
tatcgaaaaa gtctcctggc tctagtagtc ttacctgtga tgattggact tgggggagtt   420
ttgattggtt ttgaccaatt ctttactctt ttccatcaaa ttctctttgt gggagatgat   480
acctggcttt ttgatccagc caaggatcct gttattatga ttttgccaga gaccttcttt   540
cttcatgcct tcctcctctt ttttgccctc tatgaaaact tctttggcta tctgtatctg   600
aaaagtcgta ggaag                                                    615

<210>   2854
<211>   205
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903306 (e-115)

<400>   2854
Met Lys Thr Lys Leu Ile Phe Trp Gly Ser Met Leu Phe Leu Leu Ser 
1               5                   10                  15      

Leu Ser Ile Leu Leu Thr Ile Tyr Leu Ala Trp Ile Phe Tyr Pro Met 
            20                  25                  30          

Glu Ile Gln Trp Leu Asn Leu Thr Asn Arg Val Tyr Leu Lys Pro Glu 
        35                  40                  45              

Thr Ile Gln Tyr Asn Phe His Ile Leu Met Asn Tyr Leu Thr Asn Pro 
    50                  55                  60                  

Phe Ser Gln Val Leu Gln Met Pro Asp Phe Arg Ser Ser Ala Ala Gly 
65                  70                  75                  80  

Leu His His Phe Ala Val Val Lys Asn Leu Phe His Leu Val Gln Leu 
                85                  90                  95      

Val Ala Leu Val Thr Leu Pro Ser Phe Tyr Val Phe Val Asn Arg Ile 
            100                 105                 110         

Val Lys Lys Asp Phe Leu Ser Leu Tyr Arg Lys Ser Leu Leu Ala Leu 
        115                 120                 125             

Val Val Leu Pro Val Met Ile Gly Leu Gly Gly Val Leu Ile Gly Phe 
    130                 135                 140                 

Asp Gln Phe Phe Thr Leu Phe His Gln Ile Leu Phe Val Gly Asp Asp 
145                 150                 155                 160 

Thr Trp Leu Phe Asp Pro Ala Lys Asp Pro Val Ile Met Ile Leu Pro 
                165                 170                 175     

Glu Thr Phe Phe Leu His Ala Phe Leu Leu Phe Phe Ala Leu Tyr Glu 
            180                 185                 190         

Asn Phe Phe Gly Tyr Leu Tyr Leu Lys Ser Arg Arg Lys 
        195                 200                 205 

<210>   2855
<211>   771
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2855
atgaaatata aaggctattt aattgattta gacggaacca tttataaggg gaaagaccga   60
atccctgctg gagagacttt tgttcatgaa ttgcaaaagc gggacattcc ctatctcttt   120
gtaaccaaca atacaacccg cactccagag agtgttaagg agatgttggc tcagaatttt   180
aatatcgata cgcccctatc gactgtctac acagcgactt tggcaaccat cgactatatg   240
aatgatttgg ggcttgaaaa gaccgtctat gtcgtcggag aagcaggact caaggaagcc   300
atcaaggcgg ctggttatgt ggaagacaag gaaaaacctg cctacgtggt agttggtctg   360
gattggcaag tcgactatga aaaatttgcc acagcaactc ttgctattca aaagggtgcc   420
cattttatcg gaaccaatcc tgacctcaac atcccgacgg aacgcggtct tttgccaggt   480
gctggctcac tgattacgct gcttgaagta gcgacacgag tgaagccggt ttatatcgga   540
aaaccaaatg ccatcattat ggacaaggcg gttgagcact taggtttgga acgtgaagag   600
ttaatcatgg ttggggacaa ttatttgact gatattcggg ctgggattga caatggcatt   660
ccaacgctct tggtgacgac aggttttact aaggcagaag aagtagctgg cctgccaatc   720
gcaccgacac atgtggtttc tagccttgcg gagtgggatt ttgatgaaaa c            771

<210>   2856
<211>   257
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydrolase, haloacid dehalogenase-like family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903307 (e-147)

<400>   2856
Met Lys Tyr Lys Gly Tyr Leu Ile Asp Leu Asp Gly Thr Ile Tyr Lys 
1               5                   10                  15      

Gly Lys Asp Arg Ile Pro Ala Gly Glu Thr Phe Val His Glu Leu Gln 
            20                  25                  30          

Lys Arg Asp Ile Pro Tyr Leu Phe Val Thr Asn Asn Thr Thr Arg Thr 
        35                  40                  45              

Pro Glu Ser Val Lys Glu Met Leu Ala Gln Asn Phe Asn Ile Asp Thr 
    50                  55                  60                  

Pro Leu Ser Thr Val Tyr Thr Ala Thr Leu Ala Thr Ile Asp Tyr Met 
65                  70                  75                  80  

Asn Asp Leu Gly Leu Glu Lys Thr Val Tyr Val Val Gly Glu Ala Gly 
                85                  90                  95      

Leu Lys Glu Ala Ile Lys Ala Ala Gly Tyr Val Glu Asp Lys Glu Lys 
            100                 105                 110         

Pro Ala Tyr Val Val Val Gly Leu Asp Trp Gln Val Asp Tyr Glu Lys 
        115                 120                 125             

Phe Ala Thr Ala Thr Leu Ala Ile Gln Lys Gly Ala His Phe Ile Gly 
    130                 135                 140                 

Thr Asn Pro Asp Leu Asn Ile Pro Thr Glu Arg Gly Leu Leu Pro Gly 
145                 150                 155                 160 

Ala Gly Ser Leu Ile Thr Leu Leu Glu Val Ala Thr Arg Val Lys Pro 
                165                 170                 175     

Val Tyr Ile Gly Lys Pro Asn Ala Ile Ile Met Asp Lys Ala Val Glu 
            180                 185                 190         

His Leu Gly Leu Glu Arg Glu Glu Leu Ile Met Val Gly Asp Asn Tyr 
        195                 200                 205             

Leu Thr Asp Ile Arg Ala Gly Ile Asp Asn Gly Ile Pro Thr Leu Leu 
    210                 215                 220                 

Val Thr Thr Gly Phe Thr Lys Ala Glu Glu Val Ala Gly Leu Pro Ile 
225                 230                 235                 240 

Ala Pro Thr His Val Val Ser Ser Leu Ala Glu Trp Asp Phe Asp Glu 
                245                 250                 255     


Asn 
    

<210>   2857
<211>   735
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2857
atgggcttaa cttatcaaat gaaaatgaaa attccttttg atatggctga tatgaacggt   60
catatcaaac ttccagatgt gattttgctg tcactgcaag tttcagggat gcagtcgatt   120
gaactgggag ttagtgataa ggccattttg gaagaatata atctggtctg gattatcgta   180
gaatatgata ttgaggtggt tcgtttgcct cgttttgcgg aagaaattac catcgaaacg   240
gaagccttga gctacaatcg acttttttgc taccgtcgct ttactattta taatgaagcg   300
gagcaggagc tcatccacat gatggcgacc tttgttctca tggaccgcga cagtcgaaaa   360
gtccatgttg ttgaacctga gattgtggct ccttaccagt ctgattttga taaaaaactt   420
atccgtggac cgaagtatga gtccttggaa gaaccgatca gcaaggatta ccatgttcgt   480
ttttacgact tggatatgaa tggtcatgtc aataacagta aatacttgga ctggattttt   540
gaggtcatgg gagcggattt tttgacccac tatattccca agaaaatcaa cctcaagtat   600
gtcaaggaag ttcgaccagg tggggtgatt acatcggctg ttgaacggac tggactggaa   660
agcaagcatg aaattacaag tgatggggtt atcaatgccc aagcaatcat tacttggcaa   720
gaaataaaaa aggct                                                    735

<210>   2858
<211>   245
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acyl-ACP thioesterase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903308 (e-138)

<400>   2858
Met Gly Leu Thr Tyr Gln Met Lys Met Lys Ile Pro Phe Asp Met Ala 
1               5                   10                  15      

Asp Met Asn Gly His Ile Lys Leu Pro Asp Val Ile Leu Leu Ser Leu 
            20                  25                  30          

Gln Val Ser Gly Met Gln Ser Ile Glu Leu Gly Val Ser Asp Lys Ala 
        35                  40                  45              

Ile Leu Glu Glu Tyr Asn Leu Val Trp Ile Ile Val Glu Tyr Asp Ile 
    50                  55                  60                  

Glu Val Val Arg Leu Pro Arg Phe Ala Glu Glu Ile Thr Ile Glu Thr 
65                  70                  75                  80  

Glu Ala Leu Ser Tyr Asn Arg Leu Phe Cys Tyr Arg Arg Phe Thr Ile 
                85                  90                  95      

Tyr Asn Glu Ala Glu Gln Glu Leu Ile His Met Met Ala Thr Phe Val 
            100                 105                 110         

Leu Met Asp Arg Asp Ser Arg Lys Val His Val Val Glu Pro Glu Ile 
        115                 120                 125             

Val Ala Pro Tyr Gln Ser Asp Phe Asp Lys Lys Leu Ile Arg Gly Pro 
    130                 135                 140                 

Lys Tyr Glu Ser Leu Glu Glu Pro Ile Ser Lys Asp Tyr His Val Arg 
145                 150                 155                 160 

Phe Tyr Asp Leu Asp Met Asn Gly His Val Asn Asn Ser Lys Tyr Leu 
                165                 170                 175     

Asp Trp Ile Phe Glu Val Met Gly Ala Asp Phe Leu Thr His Tyr Ile 
            180                 185                 190         

Pro Lys Lys Ile Asn Leu Lys Tyr Val Lys Glu Val Arg Pro Gly Gly 
        195                 200                 205             

Val Ile Thr Ser Ala Val Glu Arg Thr Gly Leu Glu Ser Lys His Glu 
    210                 215                 220                 

Ile Thr Ser Asp Gly Val Ile Asn Ala Gln Ala Ile Ile Thr Trp Gln 
225                 230                 235                 240 

Glu Ile Lys Lys Ala 
                245 

<210>   2859
<211>   1128
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2859
atgcagaaaa aaccaacgtc agcctatgtg cacatcccat tttgtaccca gatttgttat   60
tattgtgatt tttcaaaggt cttcatcaaa aatcagccag tcgacagcta tttagagcat   120
ctgctggaag agtttcgttc ttatgatatt gaaaagttgt caacccttta tatcggtggt   180
ggaacaccga cagccctgtc ggctccgcaa ctggaggtgt tactgaatgg cttgactaaa   240
aacttggatt tgtctgtctt ggaagagttg accattgaag ccaatccagg cgatttggat   300
gcggataaga tagctgtttt gaaaaattcg gctgtcaatc gtgtttcgct aggtgtccag   360
acctttgatg ataagatgtt gaaaaagatt gggcgcagtc atttggagaa ggatatttat   420
gaaaatatcg atcgcctgaa actggctggt tttgacaata tctccattga tttgatttat   480
gctctgcctg gtcagaccat ggagcaagta aaggaaaatg tggctaaagc cattggattg   540
gatattcccc acatgagttt gtatagtttg attttagaaa accatacggt ctttatgaac   600
cggatgcgac gtgggaaatt gcctctgcct aaggaggaac tagaagcgga gatgtttgag   660
tacatcattg cagagctgga gcgagcgggt tttgagcatt atgagatttc taatttctcc   720
aaacccggtt ttgaaagtcg tcataatctc atgtactggg acaatgctga atactatggt   780
attggtgcag gggcatctgg ttatgtcaat ggagtacgct ataaaaatca tggtcccatt   840
cgtcattatc tcagtgcggt tgaggaaggc aatgcttgta ttacagaaga tcacctgagt   900
caaaaggagc aaatggaaga agaaatgttc ttgggactcc gcaagaaatc cggggtttcc   960
atggcgcgat ttgaggaaaa atttggacag tcttttgctg gactttatgg agaaattgtc   1020
agagatttgg ttcaacaagg cctcatgcag attgagggtg accacgttcg catgacaaag   1080
agaggtctct ttttgggaga tactgtagca gaacgattta ttttggag                1128

<210>   2860
<211>   376
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxygen-independent coproporphyrinogen III oxidase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903309 (0.E+01)

<400>   2860
Met Gln Lys Lys Pro Thr Ser Ala Tyr Val His Ile Pro Phe Cys Thr 
1               5                   10                  15      

Gln Ile Cys Tyr Tyr Cys Asp Phe Ser Lys Val Phe Ile Lys Asn Gln 
            20                  25                  30          

Pro Val Asp Ser Tyr Leu Glu His Leu Leu Glu Glu Phe Arg Ser Tyr 
        35                  40                  45              

Asp Ile Glu Lys Leu Ser Thr Leu Tyr Ile Gly Gly Gly Thr Pro Thr 
    50                  55                  60                  

Ala Leu Ser Ala Pro Gln Leu Glu Val Leu Leu Asn Gly Leu Thr Lys 
65                  70                  75                  80  

Asn Leu Asp Leu Ser Val Leu Glu Glu Leu Thr Ile Glu Ala Asn Pro 
                85                  90                  95      

Gly Asp Leu Asp Ala Asp Lys Ile Ala Val Leu Lys Asn Ser Ala Val 
            100                 105                 110         

Asn Arg Val Ser Leu Gly Val Gln Thr Phe Asp Asp Lys Met Leu Lys 
        115                 120                 125             

Lys Ile Gly Arg Ser His Leu Glu Lys Asp Ile Tyr Glu Asn Ile Asp 
    130                 135                 140                 

Arg Leu Lys Leu Ala Gly Phe Asp Asn Ile Ser Ile Asp Leu Ile Tyr 
145                 150                 155                 160 

Ala Leu Pro Gly Gln Thr Met Glu Gln Val Lys Glu Asn Val Ala Lys 
                165                 170                 175     

Ala Ile Gly Leu Asp Ile Pro His Met Ser Leu Tyr Ser Leu Ile Leu 
            180                 185                 190         

Glu Asn His Thr Val Phe Met Asn Arg Met Arg Arg Gly Lys Leu Pro 
        195                 200                 205             

Leu Pro Lys Glu Glu Leu Glu Ala Glu Met Phe Glu Tyr Ile Ile Ala 
    210                 215                 220                 

Glu Leu Glu Arg Ala Gly Phe Glu His Tyr Glu Ile Ser Asn Phe Ser 
225                 230                 235                 240 

Lys Pro Gly Phe Glu Ser Arg His Asn Leu Met Tyr Trp Asp Asn Ala 
                245                 250                 255     

Glu Tyr Tyr Gly Ile Gly Ala Gly Ala Ser Gly Tyr Val Asn Gly Val 
            260                 265                 270         

Arg Tyr Lys Asn His Gly Pro Ile Arg His Tyr Leu Ser Ala Val Glu 
        275                 280                 285             

Glu Gly Asn Ala Cys Ile Thr Glu Asp His Leu Ser Gln Lys Glu Gln 
    290                 295                 300                 

Met Glu Glu Glu Met Phe Leu Gly Leu Arg Lys Lys Ser Gly Val Ser 
305                 310                 315                 320 

Met Ala Arg Phe Glu Glu Lys Phe Gly Gln Ser Phe Ala Gly Leu Tyr 
                325                 330                 335     

Gly Glu Ile Val Arg Asp Leu Val Gln Gln Gly Leu Met Gln Ile Glu 
            340                 345                 350         

Gly Asp His Val Arg Met Thr Lys Arg Gly Leu Phe Leu Gly Asp Thr 
        355                 360                 365             

Val Ala Glu Arg Phe Ile Leu Glu 
    370                 375     

<210>   2861
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2861
atgggtaaat tatcctcaat ccttttagga accgtttcag gtgcagctct tgccttgttt   60
ttaacaagtg ataagggcaa acaagtttgc agtcaggctc aagattttct agatgatttg   120
agagaagatc cggagtatgc caaggagcaa gtctgtgaaa aactgacaga agttaaggag   180
caggctacag attttgttct gaaaacaaaa gaacaggttg agtcaggtga aatcactgtg   240
gacagtatac ttgctcaaac taaatcctat gcttttcaag cgacagaagc atcaaaaaat   300
caattaaata atctcaagga gcaatggcaa gaaaaagccg aagctcttga tgactcagaa   360
gagattgtga ttgatataac agaagaa                                       387

<210>   2862
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903310 (6.E-67)

<400>   2862
Met Gly Lys Leu Ser Ser Ile Leu Leu Gly Thr Val Ser Gly Ala Ala 
1               5                   10                  15      

Leu Ala Leu Phe Leu Thr Ser Asp Lys Gly Lys Gln Val Cys Ser Gln 
            20                  25                  30          

Ala Gln Asp Phe Leu Asp Asp Leu Arg Glu Asp Pro Glu Tyr Ala Lys 
        35                  40                  45              

Glu Gln Val Cys Glu Lys Leu Thr Glu Val Lys Glu Gln Ala Thr Asp 
    50                  55                  60                  

Phe Val Leu Lys Thr Lys Glu Gln Val Glu Ser Gly Glu Ile Thr Val 
65                  70                  75                  80  

Asp Ser Ile Leu Ala Gln Thr Lys Ser Tyr Ala Phe Gln Ala Thr Glu 
                85                  90                  95      

Ala Ser Lys Asn Gln Leu Asn Asn Leu Lys Glu Gln Trp Gln Glu Lys 
            100                 105                 110         

Ala Glu Ala Leu Asp Asp Ser Glu Glu Ile Val Ile Asp Ile Thr Glu 
        115                 120                 125             

Glu 
    

<210>   2863
<211>   381
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2863
atgttagaag ttgcatatat tcttgttgcc ctagctttga ttgtcttttt ggtctatctg   60
atcattactg tacaaaagct tggtcgtgtc atcgatgaaa cagaaaagac gattaaaacc   120
ttgacttcag atgtggatgt gaccttgcat cacaccaatg agttgttggc taaggtcaat   180
gtcttggcag atgatatcaa tgtcaaggtg gctacgattg atccactctt cagtgctgtt   240
gcagatttat ctctatctgt ttcagacctc aatgaccatg cgcgtgtctt gagcaagaaa   300
gcttcatcag ctggttcaaa aacactcaag actggtgcaa gtctgtcagc tcttcgtctt   360
gcaagtaaat ttttcaaaaa a                                             381

<210>   2864
<211>   127
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903311 (5.E-64)

<400>   2864
Met Leu Glu Val Ala Tyr Ile Leu Val Ala Leu Ala Leu Ile Val Phe 
1               5                   10                  15      


Leu Val Tyr Leu Ile Ile Thr Val Gln Lys Leu Gly Arg Val Ile Asp 
            20                  25                  30          

Glu Thr Glu Lys Thr Ile Lys Thr Leu Thr Ser Asp Val Asp Val Thr 
        35                  40                  45              

Leu His His Thr Asn Glu Leu Leu Ala Lys Val Asn Val Leu Ala Asp 
    50                  55                  60                  

Asp Ile Asn Val Lys Val Ala Thr Ile Asp Pro Leu Phe Ser Ala Val 
65                  70                  75                  80  

Ala Asp Leu Ser Leu Ser Val Ser Asp Leu Asn Asp His Ala Arg Val 
                85                  90                  95      

Leu Ser Lys Lys Ala Ser Ser Ala Gly Ser Lys Thr Leu Lys Thr Gly 
            100                 105                 110         

Ala Ser Leu Ser Ala Leu Arg Leu Ala Ser Lys Phe Phe Lys Lys 
        115                 120                 125         

<210>   2865
<211>   798
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2865
atgaggtgca aaatgcttga tccaattgct attcaactag gacccctagc cattcgttgg   60
tatgccttat gtattgtgac aggcttgatt cttgcggttt atttgaccat gaaagaagca   120
cctagaaaga agatcatacc agacgatatt ttagatttta tcttagtagc ctttcccttg   180
gctattttag gagctcgtct ctactatgtt attttccgat ttgattacta tagtcagaat   240
ttaggagaga tttttgccat ttggaatggt ggtttggcca tttacggtgg tttgataact   300
ggggctcttg tgctctatat ctttgctgac cgtaaactca tcaatacttg ggattttcta   360
gatattgcgg cgcctagcgt tatgattgct caaagtttgg ggcgttgggg taatttcttt   420
aaccaagaag cttatggtgc aacagtggat aatctggatt atctacctgg ctttatccgt   480
gaccagatgt atattgaggg gagctaccgt caaccgactt tcctttatga gtctctatgg   540
aatctgcttg gctttgcctt gattctgatt tttagacgga aatggaagag tctcagacga   600
ggtcatatca cggcctttta cttgatttgg tatggtttcg gtcgtatggt tatcgaaggt   660
atgcgaacag atagtctcat gttcttcggc tttcgagtgt cccaatggct gtcagttgtc   720
cttatcggtc tcggtataat gatcgttatt tatcaaaatc gaaagaaggc cccttactat   780
attacagagg aggaaaac                                                 798

<210>   2866
<211>   266
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   prolipoprotein diacylglyceryl transferase (lgt)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903312 (e-152)

<400>   2866
Met Arg Cys Lys Met Leu Asp Pro Ile Ala Ile Gln Leu Gly Pro Leu 
1               5                   10                  15      

Ala Ile Arg Trp Tyr Ala Leu Cys Ile Val Thr Gly Leu Ile Leu Ala 
            20                  25                  30          

Val Tyr Leu Thr Met Lys Glu Ala Pro Arg Lys Lys Ile Ile Pro Asp 
        35                  40                  45              

Asp Ile Leu Asp Phe Ile Leu Val Ala Phe Pro Leu Ala Ile Leu Gly 
    50                  55                  60                  

Ala Arg Leu Tyr Tyr Val Ile Phe Arg Phe Asp Tyr Tyr Ser Gln Asn 
65                  70                  75                  80  

Leu Gly Glu Ile Phe Ala Ile Trp Asn Gly Gly Leu Ala Ile Tyr Gly 
                85                  90                  95      

Gly Leu Ile Thr Gly Ala Leu Val Leu Tyr Ile Phe Ala Asp Arg Lys 
            100                 105                 110         

Leu Ile Asn Thr Trp Asp Phe Leu Asp Ile Ala Ala Pro Ser Val Met 
        115                 120                 125             

Ile Ala Gln Ser Leu Gly Arg Trp Gly Asn Phe Phe Asn Gln Glu Ala 
    130                 135                 140                 

Tyr Gly Ala Thr Val Asp Asn Leu Asp Tyr Leu Pro Gly Phe Ile Arg 
145                 150                 155                 160 

Asp Gln Met Tyr Ile Glu Gly Ser Tyr Arg Gln Pro Thr Phe Leu Tyr 
                165                 170                 175     

Glu Ser Leu Trp Asn Leu Leu Gly Phe Ala Leu Ile Leu Ile Phe Arg 
            180                 185                 190         

Arg Lys Trp Lys Ser Leu Arg Arg Gly His Ile Thr Ala Phe Tyr Leu 
        195                 200                 205             

Ile Trp Tyr Gly Phe Gly Arg Met Val Ile Glu Gly Met Arg Thr Asp 
    210                 215                 220                 

Ser Leu Met Phe Phe Gly Phe Arg Val Ser Gln Trp Leu Ser Val Val 
225                 230                 235                 240 

Leu Ile Gly Leu Gly Ile Met Ile Val Ile Tyr Gln Asn Arg Lys Lys 
                245                 250                 255     

Ala Pro Tyr Tyr Ile Thr Glu Glu Glu Asn 
            260                 265     

<210>   2867
<211>   807
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2867
ttgaaggagg aaatgatgtc ggttttagta aaagaagtga ttgaaaagct tagactagac   60
attgtctatg gtgaaccaga attgcttgaa aaggaaatca atacagcgga tattacgcga   120
cctggtcttg aaatgacagg ctattttgac tactatacac cagagcggat tcaacttttg   180
gggatgaagg agtggtctta tctgatcagc atgccttcca acagccgtta tgaagttttg   240
aaaaaaatgt ttctacctga gacaccagca gtcattgttg cccgtggttt ggtggttcca   300
gaggagatgt taaaggctgc tagagaatgt aagattgcta ttttaaccag ccgtgcagct   360
accagtcgtt tatctggaga gttatctagc tatctggatt ctcgtttggc agaacgtacc   420
agtgtgcacg gtgtcttgat ggatatttat gggatgggcg tcttgattca gggagatagt   480
ggaattggta agagcgagac aggtcttgag cttgtcaaac gtggtcaccg tttggtagcc   540
gatgaccgtg tcgatatctt tgccaaggat gagattactc tctggggtga accagctgaa   600
attttgaaac acttgattga aattcgtggg gttggtatta tcgatgttat gagtctctac   660
ggtgcgagtg ctgtcaagga ttcttcacag gttcagcttg ctgtctattt ggaaaattac   720
gatacgcata agacctttga tcgtcttgga aataatgcag aggaacttga agtttctggc   780
gtacattcct cgtattcgta ttccagt                                       807

<210>   2868
<211>   269
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Hpr(Ser) kinase/phosphatase FRAMESHIFT (hprK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903313 (e-173)

<400>   2868
Met Lys Glu Glu Met Met Ser Val Leu Val Lys Glu Val Ile Glu Lys 
1               5                   10                  15      

Leu Arg Leu Asp Ile Val Tyr Gly Glu Pro Glu Leu Leu Glu Lys Glu 
            20                  25                  30          

Ile Asn Thr Ala Asp Ile Thr Arg Pro Gly Leu Glu Met Thr Gly Tyr 
        35                  40                  45              

Phe Asp Tyr Tyr Thr Pro Glu Arg Ile Gln Leu Leu Gly Met Lys Glu 
    50                  55                  60                  

Trp Ser Tyr Leu Ile Ser Met Pro Ser Asn Ser Arg Tyr Glu Val Leu 
65                  70                  75                  80  

Lys Lys Met Phe Leu Pro Glu Thr Pro Ala Val Ile Val Ala Arg Gly 
                85                  90                  95      

Leu Val Val Pro Glu Glu Met Leu Lys Ala Ala Arg Glu Cys Lys Ile 
            100                 105                 110         

Ala Ile Leu Thr Ser Arg Ala Ala Thr Ser Arg Leu Ser Gly Glu Leu 
        115                 120                 125             

Ser Ser Tyr Leu Asp Ser Arg Leu Ala Glu Arg Thr Ser Val His Gly 
    130                 135                 140                 

Val Leu Met Asp Ile Tyr Gly Met Gly Val Leu Ile Gln Gly Asp Ser 
145                 150                 155                 160 

Gly Ile Gly Lys Ser Glu Thr Gly Leu Glu Leu Val Lys Arg Gly His 
                165                 170                 175     

Arg Leu Val Ala Asp Asp Arg Val Asp Ile Phe Ala Lys Asp Glu Ile 
            180                 185                 190         

Thr Leu Trp Gly Glu Pro Ala Glu Ile Leu Lys His Leu Ile Glu Ile 
        195                 200                 205             

Arg Gly Val Gly Ile Ile Asp Val Met Ser Leu Tyr Gly Ala Ser Ala 
    210                 215                 220                 

Val Lys Asp Ser Ser Gln Val Gln Leu Ala Val Tyr Leu Glu Asn Tyr 
225                 230                 235                 240 

Asp Thr His Lys Thr Phe Asp Arg Leu Gly Asn Asn Ala Glu Glu Leu 
                245                 250                 255     

Glu Val Ser Gly Val His Ser Ser Tyr Ser Tyr Ser Ser 
            260                 265                 

<210>   2869
<211>   198
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2869
ttgaacttga agggagtgaa aaaaatgtct aaaacagtag tacgtaagaa tgaatctctt   60
gacgacgcac ttcgccgttt caaacgtgcg gttactaaag ctggtactct tcaagaaaca   120
cgcaaacgtg aattctatga aaaaccttct gtaaaacgta aacgtaaatc agaagtagct   180
cgtaaacgta aaaaattc                                                 198

<210>   2870
<211>   66
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S21 (rpsU)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903314 (5.E-28)

<400>   2870
Met Asn Leu Lys Gly Val Lys Lys Met Ser Lys Thr Val Val Arg Lys 
1               5                   10                  15      

Asn Glu Ser Leu Asp Asp Ala Leu Arg Arg Phe Lys Arg Ala Val Thr 
            20                  25                  30          

Lys Ala Gly Thr Leu Gln Glu Thr Arg Lys Arg Glu Phe Tyr Glu Lys 
        35                  40                  45              

Pro Ser Val Lys Arg Lys Arg Lys Ser Glu Val Ala Arg Lys Arg Lys 
    50                  55                  60                  

Lys Phe 
65      

<210>   2871
<211>   714
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2871
atggaggatg aaaagatgaa agttattaaa gttgaaaacc aagttcaagg tggaaaagtt   60
gcttttgaga ttttgaagga aaaattggct aatggagctc aaactctagg acttgcgaca   120
ggaagtagcc cacttgaatt ttacaaggaa attgttgaga gtgaccttga tttttcaaat   180
ctaaccagtg tcaaccttga tgagtatgtg ggccttgatg gggacaatcc acagtcttat   240
cgttacttca tgcaagaaaa cttgttcaac caaaaaccat ttaaagaaag tttcttgcct   300
cgtggtgtta aggacaatgc tgaagctgaa gttgaacgct acaaccaaat tttggctgac   360
catccagttg acctccaaat cttgggaatc ggtcgcaatg ggcatatcgg ctttaatgag   420
cctggcactc catttgacag tcaaacgcat ctagtagaac ttgaccagtc tactatcgaa   480
gccaatgcac gcttctttgc caagattgaa gacgtcccaa cccaagctat ttcaatgggg   540
attaaaaaca ttttggatgc caagtctatt attctttttg cttacggtga gtcgaaagca   600
gaagccattg ccggaacagt atctggccca gtgactgaga acctacctgc aagtagcctc   660
caaaatcacc ctgatgtaac catcatcgca gatgctgaag cgcttagctt actc         714

<210>   2872
<211>   238
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucosamine-6-phosphate isomerase (nagB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903315 (e-130)

<400>   2872
Met Glu Asp Glu Lys Met Lys Val Ile Lys Val Glu Asn Gln Val Gln 
1               5                   10                  15      

Gly Gly Lys Val Ala Phe Glu Ile Leu Lys Glu Lys Leu Ala Asn Gly 
            20                  25                  30          

Ala Gln Thr Leu Gly Leu Ala Thr Gly Ser Ser Pro Leu Glu Phe Tyr 
        35                  40                  45              

Lys Glu Ile Val Glu Ser Asp Leu Asp Phe Ser Asn Leu Thr Ser Val 
    50                  55                  60                  

Asn Leu Asp Glu Tyr Val Gly Leu Asp Gly Asp Asn Pro Gln Ser Tyr 
65                  70                  75                  80  

Arg Tyr Phe Met Gln Glu Asn Leu Phe Asn Gln Lys Pro Phe Lys Glu 
                85                  90                  95      

Ser Phe Leu Pro Arg Gly Val Lys Asp Asn Ala Glu Ala Glu Val Glu 
            100                 105                 110         

Arg Tyr Asn Gln Ile Leu Ala Asp His Pro Val Asp Leu Gln Ile Leu 
        115                 120                 125             

Gly Ile Gly Arg Asn Gly His Ile Gly Phe Asn Glu Pro Gly Thr Pro 
    130                 135                 140                 

Phe Asp Ser Gln Thr His Leu Val Glu Leu Asp Gln Ser Thr Ile Glu 
145                 150                 155                 160 

Ala Asn Ala Arg Phe Phe Ala Lys Ile Glu Asp Val Pro Thr Gln Ala 
                165                 170                 175     

Ile Ser Met Gly Ile Lys Asn Ile Leu Asp Ala Lys Ser Ile Ile Leu 
            180                 185                 190         

Phe Ala Tyr Gly Glu Ser Lys Ala Glu Ala Ile Ala Gly Thr Val Ser 
        195                 200                 205             

Gly Pro Val Thr Glu Asn Leu Pro Ala Ser Ser Leu Gln Asn His Pro 
    210                 215                 220                 

Asp Val Thr Ile Ile Ala Asp Ala Glu Ala Leu Ser Leu Leu 
225                 230                 235             

<210>   2873
<211>   1038
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2873
atgaacaaat atatgaatac agctgatttt gatttccact tgccagagga attgattgcc   60
caaacgcccc ttgaaaaacg tgatgcctcc aaactcctca tcgtcaaccg tgagacagga   120
gaaatgcaag ataaacattt ccactctatt attgatatgc tggaacctgg tgatgccctt   180
gtcatgaacg acacccgagt tctccctgcc cgcctctatg gtcaaaaagt ggagacagga   240
ggtcatgtgg aacttctcct ccttaagaac actagtggag acgagtggga agttctggct   300
aaacctgcca aacgcctcaa ggtcggtact cgtatcagct ttggtgatgg ccgcctcagc   360
gctgtcgtta cagaagaatt gacccacggg ggacgcattg tccgctttga ataccaagga   420
attttcctag aagtcttgga aagtctggga gaaatgcctc tgccacctta tatccacgaa   480
aaattagatg accgtgaacg ttatcaaacc gtctacgcca aggaaagtgg ctctgctgca   540
gcaccgactg ctggtcttca cttcaccaaa gaactgctgg cagaaatcca agctaagggt   600
gttcatctag tctatctgac tctccatgtc ggactcggaa cctttagacc tgtttctgtg   660
gataatctgg acgaacacga aatgcactca gagttctatc aactttctga ggaagctgct   720
gccacccttc gctctgtcaa aaaaaatggt ggtcgtgtca tcgctgtcgg aaccacttct   780
atccgcacct tggaaactat tggttccaag tttgatgggc aaatccaagc agattctggt   840
tggaccaata tctttatcaa acctgggtat gagtggaagg tcgtggatgc cttctcaacc   900
aacttccacc tgccaaaatc aactctggtc atgttggttt ctgcctttgc aggccgtgaa   960
ttagtcttag atgcctacca ccattccatc caagaacact accgcttctt cagttttggt   1020
gacgccatgt ttatttat                                                 1038

<210>   2874
<211>   346
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   S-adenosylmethionine tRNA ribosyltransferase-isomerase (queA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903316 (0.E+01)

<400>   2874
Met Asn Lys Tyr Met Asn Thr Ala Asp Phe Asp Phe His Leu Pro Glu 
1               5                   10                  15      

Glu Leu Ile Ala Gln Thr Pro Leu Glu Lys Arg Asp Ala Ser Lys Leu 
            20                  25                  30          

Leu Ile Val Asn Arg Glu Thr Gly Glu Met Gln Asp Lys His Phe His 
        35                  40                  45              

Ser Ile Ile Asp Met Leu Glu Pro Gly Asp Ala Leu Val Met Asn Asp 
    50                  55                  60                  

Thr Arg Val Leu Pro Ala Arg Leu Tyr Gly Gln Lys Val Glu Thr Gly 
65                  70                  75                  80  

Gly His Val Glu Leu Leu Leu Leu Lys Asn Thr Ser Gly Asp Glu Trp 
                85                  90                  95      

Glu Val Leu Ala Lys Pro Ala Lys Arg Leu Lys Val Gly Thr Arg Ile 
            100                 105                 110         

Ser Phe Gly Asp Gly Arg Leu Ser Ala Val Val Thr Glu Glu Leu Thr 
        115                 120                 125             

His Gly Gly Arg Ile Val Arg Phe Glu Tyr Gln Gly Ile Phe Leu Glu 
    130                 135                 140                 

Val Leu Glu Ser Leu Gly Glu Met Pro Leu Pro Pro Tyr Ile His Glu 
145                 150                 155                 160 

Lys Leu Asp Asp Arg Glu Arg Tyr Gln Thr Val Tyr Ala Lys Glu Ser 
                165                 170                 175     

Gly Ser Ala Ala Ala Pro Thr Ala Gly Leu His Phe Thr Lys Glu Leu 
            180                 185                 190         

Leu Ala Glu Ile Gln Ala Lys Gly Val His Leu Val Tyr Leu Thr Leu 
        195                 200                 205             

His Val Gly Leu Gly Thr Phe Arg Pro Val Ser Val Asp Asn Leu Asp 
    210                 215                 220                 

Glu His Glu Met His Ser Glu Phe Tyr Gln Leu Ser Glu Glu Ala Ala 
225                 230                 235                 240 

Ala Thr Leu Arg Ser Val Lys Lys Asn Gly Gly Arg Val Ile Ala Val 
                245                 250                 255     

Gly Thr Thr Ser Ile Arg Thr Leu Glu Thr Ile Gly Ser Lys Phe Asp 
            260                 265                 270         

Gly Gln Ile Gln Ala Asp Ser Gly Trp Thr Asn Ile Phe Ile Lys Pro 
        275                 280                 285             

Gly Tyr Glu Trp Lys Val Val Asp Ala Phe Ser Thr Asn Phe His Leu 
    290                 295                 300                 

Pro Lys Ser Thr Leu Val Met Leu Val Ser Ala Phe Ala Gly Arg Glu 
305                 310                 315                 320 

Leu Val Leu Asp Ala Tyr His His Ser Ile Gln Glu His Tyr Arg Phe 
                325                 330                 335     

Phe Ser Phe Gly Asp Ala Met Phe Ile Tyr 
            340                 345     

<210>   2875
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2875
atgaaaatca aagagcaaac tagaaaacta gtcgcaggtt gctcaaagta ctgctttgag   60
gttgtagata gaactgacga agtcagtcac atatataatc caagg                   105

<210>   2876
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   2876
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Val Ala Gly Cys Ser Lys 
1               5                   10                  15      

Tyr Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser His Ile Tyr 
            20                  25                  30          

Asn Pro Arg 
        35  

<210>   2877
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2877
atggtaaaaa gacgtataag gagagggacg agagaacctg aaaaagttgt tgttcctgag   60
caatcatcta ttccttcgta tcctgtatct gttacatcta accaaggaac agatgtagca   120
gtagaaccag ctaaagcagt tgctccaaca acagactgga aacaagaaaa tggtatgtgg   180
tatttttata atactgatgg ttccatggca acaggttggg tacaagttaa tagttcatgg   240
tactacctca acagcaacgg ttctatgaaa gtcaatcaat ggttccaagt tggtggtaaa   300
tggtattatg taaatacatc gggtgagtta gcggtcaata caagtataga tggctataga   360
gtcaatgata atggtgaatg ggtgcgt                                       387

<210>   2878
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pspC-related protein

<400>   2878
Met Val Lys Arg Arg Ile Arg Arg Gly Thr Arg Glu Pro Glu Lys Val 
1               5                   10                  15      

Val Val Pro Glu Gln Ser Ser Ile Pro Ser Tyr Pro Val Ser Val Thr 
            20                  25                  30          

Ser Asn Gln Gly Thr Asp Val Ala Val Glu Pro Ala Lys Ala Val Ala 
        35                  40                  45              

Pro Thr Thr Asp Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
    50                  55                  60                  

Thr Asp Gly Ser Met Ala Thr Gly Trp Val Gln Val Asn Ser Ser Trp 
65                  70                  75                  80  

Tyr Tyr Leu Asn Ser Asn Gly Ser Met Lys Val Asn Gln Trp Phe Gln 
                85                  90                  95      

Val Gly Gly Lys Trp Tyr Tyr Val Asn Thr Ser Gly Glu Leu Ala Val 
            100                 105                 110         

Asn Thr Ser Ile Asp Gly Tyr Arg Val Asn Asp Asn Gly Glu Trp Val 
        115                 120                 125             

Arg 
    

<210>   2879
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2879
atggcaaaat ctaatactaa taagcgctat gcaatacgta aactcggaaa gatttttggt   60
tctgcggtaa tcgggctaac tttattttta ggaggaatc                          99

<210>   2880
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein

<400>   2880
Met Ala Lys Ser Asn Thr Asn Lys Arg Tyr Ala Ile Arg Lys Leu Gly 
1               5                   10                  15      

Lys Ile Phe Gly Ser Ala Val Ile Gly Leu Thr Leu Phe Leu Gly Gly 
            20                  25                  30          

Ile 
    

<210>   2881
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2881
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattgtt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg tgggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   2882
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903941 (2.E-46)

<400>   2882
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   2883
<211>   549
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2883
atgaaatcta tcggtacgca aatattacag acagaacgtt tgattttaag aagatttgtg   60
gagagtgatg cagaagccat gtttcaaaat tgggcttcat ccgctgagaa tctgacctat   120
gttacctggg atccccatcc tgatgtcgaa atcactcgaa actcgatttg caattgggtt   180
gcttcctata ctaatctcaa ctattataaa tgggccattt gtctaaaaga aaacccagag   240
caagtaatag gagatatcag cattgttaag atagacgagg ctgatttaag ctgtgaaatt   300

ggctatgtgt taggcaaggc ttactgggga aatggtatga tgacagagac tttgaaagct   360
atcttggact tttgttttac tcaagcaggt tttcaaaagg tcagagcacg ttatgccagt   420
ctcaacccag cttcaggtcg tgtcatggaa aaggctggaa tgtcctatct acaaaccatt   480
gttaatggtg tagagagaaa aggctatctt gcggatctta tttattatgg tataagtagg   540
gaagaatgt                                                           549

<210>   2884
<211>   183
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   2884
Met Lys Ser Ile Gly Thr Gln Ile Leu Gln Thr Glu Arg Leu Ile Leu 
1               5                   10                  15      

Arg Arg Phe Val Glu Ser Asp Ala Glu Ala Met Phe Gln Asn Trp Ala 
            20                  25                  30          

Ser Ser Ala Glu Asn Leu Thr Tyr Val Thr Trp Asp Pro His Pro Asp 
        35                  40                  45              

Val Glu Ile Thr Arg Asn Ser Ile Cys Asn Trp Val Ala Ser Tyr Thr 
    50                  55                  60                  

Asn Leu Asn Tyr Tyr Lys Trp Ala Ile Cys Leu Lys Glu Asn Pro Glu 
65                  70                  75                  80  

Gln Val Ile Gly Asp Ile Ser Ile Val Lys Ile Asp Glu Ala Asp Leu 
                85                  90                  95      

Ser Cys Glu Ile Gly Tyr Val Leu Gly Lys Ala Tyr Trp Gly Asn Gly 
            100                 105                 110         

Met Met Thr Glu Thr Leu Lys Ala Ile Leu Asp Phe Cys Phe Thr Gln 
        115                 120                 125             

Ala Gly Phe Gln Lys Val Arg Ala Arg Tyr Ala Ser Leu Asn Pro Ala 
    130                 135                 140                 

Ser Gly Arg Val Met Glu Lys Ala Gly Met Ser Tyr Leu Gln Thr Ile 
145                 150                 155                 160 

Val Asn Gly Val Glu Arg Lys Gly Tyr Leu Ala Asp Leu Ile Tyr Tyr 
                165                 170                 175     

Gly Ile Ser Arg Glu Glu Cys 
            180             

<210>   2885
<211>   822
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2885
atgagtttgc aagaaacgat tatccaagag ctgggtgtca aaccagtgat tgatgcccag   60
gaagaaatcc gtcgttctat tgatttctta aaaagatatc tgaaaaaaca tcccttccta   120
aaaacctttg tactagggat ttctggggga caagactcaa ccttggcagg acgtttggcg   180
caattagcta tggaagaact gcgagctgaa acgggagacg atagctacaa atttatcgct   240
gtccgcctgc catacggagt gcaagctgat gaagcagatg ctcaaaaagc cctagccttc   300
atccagccag atgtcagctt ggttgtgaat atcaaggaat cagctgatgc catgacagct   360
gcagttgaag cgacaggtag tcctgtttca gacttcaaca aggggaatat caaggcacgt   420
tgccgtatga ttgctcagta tgcccttgct ggttcccata gcggagcggt cattggaaca   480
gaccacgccg cggaaaatat cacaggtttc tttaccaagt ttggtgacgg cggtgcggat   540
attctccctc tttaccgcct caataaacgc caaggaaaac agctcttgca gaaacttggc   600
gcagagccag ccctttatga aaaaatccca acggcagacc tagaagaaga taaaccaggc   660
ctagctgacg aagtcgcact tggagtcacc tacgcagaga ttgacgacta cctagaaggc   720
aaaacaatca gcccagaagc tcaagcgacc attgaaaact ggtggcacaa aggccaacac   780
aaacgccact tacccatcac cgtatttgat gacttttggg ag                      822

<210>   2886
<211>   274
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   NH(3)-dependent NAD(+) synthetase (nadE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903319 (e-157)

<400>   2886
Met Ser Leu Gln Glu Thr Ile Ile Gln Glu Leu Gly Val Lys Pro Val 
1               5                   10                  15      

Ile Asp Ala Gln Glu Glu Ile Arg Arg Ser Ile Asp Phe Leu Lys Arg 
            20                  25                  30          

Tyr Leu Lys Lys His Pro Phe Leu Lys Thr Phe Val Leu Gly Ile Ser 
        35                  40                  45              

Gly Gly Gln Asp Ser Thr Leu Ala Gly Arg Leu Ala Gln Leu Ala Met 
    50                  55                  60                  


Glu Glu Leu Arg Ala Glu Thr Gly Asp Asp Ser Tyr Lys Phe Ile Ala 
65                  70                  75                  80  

Val Arg Leu Pro Tyr Gly Val Gln Ala Asp Glu Ala Asp Ala Gln Lys 
                85                  90                  95      

Ala Leu Ala Phe Ile Gln Pro Asp Val Ser Leu Val Val Asn Ile Lys 
            100                 105                 110         

Glu Ser Ala Asp Ala Met Thr Ala Ala Val Glu Ala Thr Gly Ser Pro 
        115                 120                 125             

Val Ser Asp Phe Asn Lys Gly Asn Ile Lys Ala Arg Cys Arg Met Ile 
    130                 135                 140                 

Ala Gln Tyr Ala Leu Ala Gly Ser His Ser Gly Ala Val Ile Gly Thr 
145                 150                 155                 160 

Asp His Ala Ala Glu Asn Ile Thr Gly Phe Phe Thr Lys Phe Gly Asp 
                165                 170                 175     

Gly Gly Ala Asp Ile Leu Pro Leu Tyr Arg Leu Asn Lys Arg Gln Gly 
            180                 185                 190         

Lys Gln Leu Leu Gln Lys Leu Gly Ala Glu Pro Ala Leu Tyr Glu Lys 
        195                 200                 205             

Ile Pro Thr Ala Asp Leu Glu Glu Asp Lys Pro Gly Leu Ala Asp Glu 
    210                 215                 220                 

Val Ala Leu Gly Val Thr Tyr Ala Glu Ile Asp Asp Tyr Leu Glu Gly 
225                 230                 235                 240 

Lys Thr Ile Ser Pro Glu Ala Gln Ala Thr Ile Glu Asn Trp Trp His 
                245                 250                 255     

Lys Gly Gln His Lys Arg His Leu Pro Ile Thr Val Phe Asp Asp Phe 
            260                 265                 270         

Trp Glu 
        

<210>   2887
<211>   1458

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2887
atgtatccag atgatagttt gacattgcac acggacttgt accagatcaa catgatgcag   60
gtttactttg accaagggat tcacaataag aaggcggtct ttgaggtgta tttccgccaa   120
cagcctttta agaacggcta tgcggttttt gcaggtttag aaagaattgt gaactatctt   180
gaagacttgc gtttttcaga tagtgatata gcctatttgg agtcgcttgg ttatcatggg   240
gcgttcttgg attaccttcg caatttcaag ttggagttga ccgttcgttc tgcccaagaa   300
ggggatttgg tttttgctaa tgaaccgatt gtgcaggtgg aaggacctct agcccaatgt   360
cagttggtcg aaacggctct tttgaacatc gtcaactacc agactttggt ggcgacgaag   420
gcagctcgta ttcgttcggt tatcgaagat gaacccttga tggagtttgg gacacgtcgg   480
gctcaagaaa tggatgcggc catctgggga acacgcgcag ctgtgattgg tggcgccaat   540
ggaaccagca acgtgcgtgc gggtaagctc tttgacattc ctgttttggg aacccatgcc   600
catgccttgg tacaggttta tggcaatgac tatgaagctt tcaaggctta cgctgcgacc   660
cacaaaaatt gtgtctttct tgtggatacc tatgacaccc ttcgcatcgg tgtaccagct   720
gccattcagg tggcgcgtga gctgggtgat cagattaact ttatgggtgt gcggattgac   780
tctggggata ttgcctacat ttctaagaaa gtccgtcagc aactggatga ggctggattt   840
acagaggcta agatttatgc ttctaatgat ctagatgaaa ataccatcct taacctcaag   900
atgcaaaagg ccaagattga tgtctggggt gtgggtacca agctgattac agcctatgac   960
cagccggctc ttggggcggt ttacaagatt gttgcaatcg aagatgaaac tggtcagatg   1020
cgcaatacga ttaagctgtc taataatgct gaaaaagttt ctacgccagg taagaagcag   1080
gtgtggcgca ttaccagtcg tgaaaaaggc aagtcagaag gcgactatat cacttatgat   1140
ggtgtggata ttagcgacat gacagaaatc aagatgttcc atccgaccta tacatacatc   1200
aagaagacgg ttcgtaattt tgatgccgtt cctctcttgg tggatatctt caaagaagga   1260
atattagttt acaacttgcc tagtttgact gacattcagg attatgcccg taaggaattt   1320
gacaagttgt gggatgagta taagcgtgtg ctcaatccgc agcactatcc agtggatttg   1380
gcgcgtgatg tatggcaaga taagatggac ttgattgata agatgcgcaa ggaagccctt   1440
ggtgaaggag aagaagaa                                                 1458

<210>   2888
<211>   486
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903320 (0.E+01)

<400>   2888
Met Tyr Pro Asp Asp Ser Leu Thr Leu His Thr Asp Leu Tyr Gln Ile 
1               5                   10                  15      

Asn Met Met Gln Val Tyr Phe Asp Gln Gly Ile His Asn Lys Lys Ala 
            20                  25                  30          

Val Phe Glu Val Tyr Phe Arg Gln Gln Pro Phe Lys Asn Gly Tyr Ala 
        35                  40                  45              

Val Phe Ala Gly Leu Glu Arg Ile Val Asn Tyr Leu Glu Asp Leu Arg 
    50                  55                  60                  

Phe Ser Asp Ser Asp Ile Ala Tyr Leu Glu Ser Leu Gly Tyr His Gly 
65                  70                  75                  80  

Ala Phe Leu Asp Tyr Leu Arg Asn Phe Lys Leu Glu Leu Thr Val Arg 
                85                  90                  95      

Ser Ala Gln Glu Gly Asp Leu Val Phe Ala Asn Glu Pro Ile Val Gln 
            100                 105                 110         

Val Glu Gly Pro Leu Ala Gln Cys Gln Leu Val Glu Thr Ala Leu Leu 
        115                 120                 125             

Asn Ile Val Asn Tyr Gln Thr Leu Val Ala Thr Lys Ala Ala Arg Ile 
    130                 135                 140                 

Arg Ser Val Ile Glu Asp Glu Pro Leu Met Glu Phe Gly Thr Arg Arg 
145                 150                 155                 160 

Ala Gln Glu Met Asp Ala Ala Ile Trp Gly Thr Arg Ala Ala Val Ile 
                165                 170                 175     

Gly Gly Ala Asn Gly Thr Ser Asn Val Arg Ala Gly Lys Leu Phe Asp 
            180                 185                 190         

Ile Pro Val Leu Gly Thr His Ala His Ala Leu Val Gln Val Tyr Gly 
        195                 200                 205             

Asn Asp Tyr Glu Ala Phe Lys Ala Tyr Ala Ala Thr His Lys Asn Cys 
    210                 215                 220                 

Val Phe Leu Val Asp Thr Tyr Asp Thr Leu Arg Ile Gly Val Pro Ala 
225                 230                 235                 240 

Ala Ile Gln Val Ala Arg Glu Leu Gly Asp Gln Ile Asn Phe Met Gly 
                245                 250                 255     

Val Arg Ile Asp Ser Gly Asp Ile Ala Tyr Ile Ser Lys Lys Val Arg 
            260                 265                 270         

Gln Gln Leu Asp Glu Ala Gly Phe Thr Glu Ala Lys Ile Tyr Ala Ser 
        275                 280                 285             

Asn Asp Leu Asp Glu Asn Thr Ile Leu Asn Leu Lys Met Gln Lys Ala 
    290                 295                 300                 

Lys Ile Asp Val Trp Gly Val Gly Thr Lys Leu Ile Thr Ala Tyr Asp 
305                 310                 315                 320 

Gln Pro Ala Leu Gly Ala Val Tyr Lys Ile Val Ala Ile Glu Asp Glu 
                325                 330                 335     

Thr Gly Gln Met Arg Asn Thr Ile Lys Leu Ser Asn Asn Ala Glu Lys 
            340                 345                 350         

Val Ser Thr Pro Gly Lys Lys Gln Val Trp Arg Ile Thr Ser Arg Glu 
        355                 360                 365             

Lys Gly Lys Ser Glu Gly Asp Tyr Ile Thr Tyr Asp Gly Val Asp Ile 
    370                 375                 380                 

Ser Asp Met Thr Glu Ile Lys Met Phe His Pro Thr Tyr Thr Tyr Ile 
385                 390                 395                 400 

Lys Lys Thr Val Arg Asn Phe Asp Ala Val Pro Leu Leu Val Asp Ile 
                405                 410                 415     

Phe Lys Glu Gly Ile Leu Val Tyr Asn Leu Pro Ser Leu Thr Asp Ile 
            420                 425                 430         

Gln Asp Tyr Ala Arg Lys Glu Phe Asp Lys Leu Trp Asp Glu Tyr Lys 
        435                 440                 445             

Arg Val Leu Asn Pro Gln His Tyr Pro Val Asp Leu Ala Arg Asp Val 
    450                 455                 460                 

Trp Gln Asp Lys Met Asp Leu Ile Asp Lys Met Arg Lys Glu Ala Leu 
465                 470                 475                 480 

Gly Glu Gly Glu Glu Glu 
                485     

<210>   2889
<211>   486
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2889
atgaaaaata gattttatta ttctcaatta ctagacgaaa gagaagaaca actgttcaat   60
aaagcgggct ctgaaagttt ctatatctgc attgctttgt cgctcctatc ttatatcatt   120
tcagtattag caccaagcct ttttaattct aatatgctgc taatcgttat catcataggg   180
acattttact ttttcaatcg tgcccgttat ctgggagtga cctactatgg tcgttttcat   240
tttacgattt tgggttgttt tttcctaacc ttggctatta cggctctttt gatgttgcag   300
aattatcaat tcaacataga aatttatcag cacaatcctt tgaattttaa atacctgtct   360
gcttgggtca ttacttatat catttacctt ccgtggatct ttattggcaa tcttggtctt   420
aagagctatg gcgaatgggc tcagaaaaaa tttgaacaag atatggatga attggagagt   480
ggagaa                                                              486

<210>   2890
<211>   162
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903321 (3.E-91)

<400>   2890
Met Lys Asn Arg Phe Tyr Tyr Ser Gln Leu Leu Asp Glu Arg Glu Glu 
1               5                   10                  15      

Gln Leu Phe Asn Lys Ala Gly Ser Glu Ser Phe Tyr Ile Cys Ile Ala 
            20                  25                  30          

Leu Ser Leu Leu Ser Tyr Ile Ile Ser Val Leu Ala Pro Ser Leu Phe 
        35                  40                  45              

Asn Ser Asn Met Leu Leu Ile Val Ile Ile Ile Gly Thr Phe Tyr Phe 
    50                  55                  60                  

Phe Asn Arg Ala Arg Tyr Leu Gly Val Thr Tyr Tyr Gly Arg Phe His 
65                  70                  75                  80  

Phe Thr Ile Leu Gly Cys Phe Phe Leu Thr Leu Ala Ile Thr Ala Leu 
                85                  90                  95      

Leu Met Leu Gln Asn Tyr Gln Phe Asn Ile Glu Ile Tyr Gln His Asn 
            100                 105                 110         

Pro Leu Asn Phe Lys Tyr Leu Ser Ala Trp Val Ile Thr Tyr Ile Ile 
        115                 120                 125             

Tyr Leu Pro Trp Ile Phe Ile Gly Asn Leu Gly Leu Lys Ser Tyr Gly 
    130                 135                 140                 


Glu Trp Ala Gln Lys Lys Phe Glu Gln Asp Met Asp Glu Leu Glu Ser 
145                 150                 155                 160 

Gly Glu 
        

<210>   2891
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2891
atgagtatta aaactataag gaggacgaag gtggctaaaa atttaaaatt aaaattagct   60
cgggtagagc gtgatttaac acaaggtcaa ctggcagagg ctgtcggggt gacacgccag   120
actattggtt taatagaggc gggaaaatac aatcccagtc tctcgctctg ccagtctatt   180
tgcagatgtt tagggaaaac cctagaccaa ctattttggg aggaagaaga tgaaaaa      237

<210>   2892
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional repressor, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903322 (5.E-41)

<400>   2892
Met Ser Ile Lys Thr Ile Arg Arg Thr Lys Val Ala Lys Asn Leu Lys 
1               5                   10                  15      

Leu Lys Leu Ala Arg Val Glu Arg Asp Leu Thr Gln Gly Gln Leu Ala 
            20                  25                  30          

Glu Ala Val Gly Val Thr Arg Gln Thr Ile Gly Leu Ile Glu Ala Gly 
        35                  40                  45              

Lys Tyr Asn Pro Ser Leu Ser Leu Cys Gln Ser Ile Cys Arg Cys Leu 
    50                  55                  60                  

Gly Lys Thr Leu Asp Gln Leu Phe Trp Glu Glu Glu Asp Glu Lys 
65                  70                  75                  

<210>   2893
<211>   399
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2893
atgaaattaa ataaacagaa gaatcggatg atttacgtct tgtctaattt tctatatgct   60
atctcagttt ccattattta tgctttgaat ggcattgtgt tactagtcat agtaagtaaa   120
ttgggtattc caggtgattt aggattaaat tttatagtag ctattgtagt caatacaatt   180
ttgttagtcc tgttttattt tctattatct tacattttct atttatacaa attgaaaagt   240
ggcttggtat ttggtatttt agtagcttta ctactcttta tctctaatat attaaatacg   300
atgatgatga atactagtaa tgatttgttt atcaaagcaa ttgaacttct tcctttttta   360
ttctttacct gtatttgtgg cttcaaatac gatgtctat                          399

<210>   2894
<211>   133
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903323 (8.E-58)

<400>   2894
Met Lys Leu Asn Lys Gln Lys Asn Arg Met Ile Tyr Val Leu Ser Asn 
1               5                   10                  15      

Phe Leu Tyr Ala Ile Ser Val Ser Ile Ile Tyr Ala Leu Asn Gly Ile 
            20                  25                  30          

Val Leu Leu Val Ile Val Ser Lys Leu Gly Ile Pro Gly Asp Leu Gly 
        35                  40                  45              

Leu Asn Phe Ile Val Ala Ile Val Val Asn Thr Ile Leu Leu Val Leu 
    50                  55                  60                  

Phe Tyr Phe Leu Leu Ser Tyr Ile Phe Tyr Leu Tyr Lys Leu Lys Ser 
65                  70                  75                  80  

Gly Leu Val Phe Gly Ile Leu Val Ala Leu Leu Leu Phe Ile Ser Asn 
                85                  90                  95      

Ile Leu Asn Thr Met Met Met Asn Thr Ser Asn Asp Leu Phe Ile Lys 
            100                 105                 110         

Ala Ile Glu Leu Leu Pro Phe Leu Phe Phe Thr Cys Ile Cys Gly Phe 
        115                 120                 125             

Lys Tyr Asp Val Tyr 
    130             

<210>   2895
<211>   132
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2895
ttgagaatta ctatgtctgg gaatattcaa aatagtgagc tttttaaatt ttttaacgaa   60
aactctatta aagtagttga ttttgaaact aaaaaagaga cgcttaaaga tatttaccta   120
aatcgttcaa aa                                                       132

<210>   2896
<211>   44
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (ABC transporter)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903324 (5.E-19)

<400>   2896
Met Arg Ile Thr Met Ser Gly Asn Ile Gln Asn Ser Glu Leu Phe Lys 
1               5                   10                  15      

Phe Phe Asn Glu Asn Ser Ile Lys Val Val Asp Phe Glu Thr Lys Lys 
            20                  25                  30          

Glu Thr Leu Lys Asp Ile Tyr Leu Asn Arg Ser Lys 
        35                  40                  

<210>   2897
<211>   732
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2897
atgagaatca aagagaaaac caataatatt aatggaggaa taaaaaatgt aagtaagcat   60
tatggtcatt caatcattct caaagatata aattttgcac ttaacaaggg tgaaattgtt   120
ggtctagcag ggagaaatgg agttggtaag agtacgttga tgaaaattct tgttcagaat   180
aatcaaccga cttcaggtaa tattataagc agtgataatg ttgggtattt aatcgaagaa   240
ccaaaattat ttttatctaa aacaggttta gagaatttaa aatatttgtc aaatttatat   300
ggtgttgact acaatcaaga aagatttaga tgtttgatcc aagagttaga tttgactcag   360
tctattaata aaaaagtaaa gacctattct ttgggtacaa aacaaaaatt agctttgctt   420
ctaactctcg ttacggaacc tgatatattg attttagatg aaccgactaa tggtttagat   480
attgaatcat cacaaatagt tttagcggtt ctaaaaaaat tagctttaca tgaaaatgtg   540
ggaattttaa tatcgagtca taaattagaa gacattgaag aaatttgtga gagagttctt   600
ttcttggaga acgggctttt gacatttcaa aaagtaggaa aagatagtca taatttcttg   660
tttgagatag ctttttcatc agctacagat agagacattt tcattaccaa acaagaattt   720
tgggatattg tt                                                       732

<210>   2898
<211>   244
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903324 (e-101)

<400>   2898
Met Arg Ile Lys Glu Lys Thr Asn Asn Ile Asn Gly Gly Ile Lys Asn 
1               5                   10                  15      

Val Ser Lys His Tyr Gly His Ser Ile Ile Leu Lys Asp Ile Asn Phe 
            20                  25                  30          

Ala Leu Asn Lys Gly Glu Ile Val Gly Leu Ala Gly Arg Asn Gly Val 
        35                  40                  45              

Gly Lys Ser Thr Leu Met Lys Ile Leu Val Gln Asn Asn Gln Pro Thr 
    50                  55                  60                  

Ser Gly Asn Ile Ile Ser Ser Asp Asn Val Gly Tyr Leu Ile Glu Glu 
65                  70                  75                  80  

Pro Lys Leu Phe Leu Ser Lys Thr Gly Leu Glu Asn Leu Lys Tyr Leu 
                85                  90                  95      

Ser Asn Leu Tyr Gly Val Asp Tyr Asn Gln Glu Arg Phe Arg Cys Leu 
            100                 105                 110         

Ile Gln Glu Leu Asp Leu Thr Gln Ser Ile Asn Lys Lys Val Lys Thr 
        115                 120                 125             

Tyr Ser Leu Gly Thr Lys Gln Lys Leu Ala Leu Leu Leu Thr Leu Val 
    130                 135                 140                 

Thr Glu Pro Asp Ile Leu Ile Leu Asp Glu Pro Thr Asn Gly Leu Asp 
145                 150                 155                 160 

Ile Glu Ser Ser Gln Ile Val Leu Ala Val Leu Lys Lys Leu Ala Leu 
                165                 170                 175     

His Glu Asn Val Gly Ile Leu Ile Ser Ser His Lys Leu Glu Asp Ile 
            180                 185                 190         

Glu Glu Ile Cys Glu Arg Val Leu Phe Leu Glu Asn Gly Leu Leu Thr 
        195                 200                 205             

Phe Gln Lys Val Gly Lys Asp Ser His Asn Phe Leu Phe Glu Ile Ala 
    210                 215                 220                 

Phe Ser Ser Ala Thr Asp Arg Asp Ile Phe Ile Thr Lys Gln Glu Phe 
225                 230                 235                 240 

Trp Asp Ile Val 
                

<210>   2899
<211>   723
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2899
atgcgtgatg ccaaccgtgg tggatgttct cagtcatgcc gttggaagta cgacctttac   60
gatatgccat ttgggaaaga acgtaagagt ttgcagggtg agattccaga agaattttca   120
atgtcagccg ttgatatgtc tatgattgac catatctcag atatgattga aaatggtgtg   180
gacagtctaa aaatcgaagg acgtatggag tctattcact atgtatcaac agtaaccaac   240
tgctacaagg cggctgtgga tgcctatctt gaaagtcctg aaaagtttga agctatcaaa   300
caagacttgg tggacgagat gtggaaggtt gcccaacgtg aactggctac aggattttac   360
tatggtacac catctgaaaa tgagcagttg tttggtgctc gtcgtaaaat ccctgagtac   420
aagtttgtcg ctgaagtggt ttcttatgat gatgcggcac aaacagcaac tattcgtcaa   480
cgaaacgtca ttaacgaagg ggaccaagtt gagttttatg gtccaggttt ccgtcatttt   540
gaaacctata ttgaagattt gcatgatgct aaaggcaata aaatcgaccg cgctccaaat   600
ccaatggaac tattgactat taaagtccca caacctgttc aatcaggaga catggttcga   660
gctcttaaag aggggcttat caatctttat aaggaagatg gaaccagcgt cacagttcgt   720
gct                                                                 723

<210>   2900
<211>   241
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidase, U32 family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903325 (e-139)

<400>   2900
Met Arg Asp Ala Asn Arg Gly Gly Cys Ser Gln Ser Cys Arg Trp Lys 
1               5                   10                  15      

Tyr Asp Leu Tyr Asp Met Pro Phe Gly Lys Glu Arg Lys Ser Leu Gln 
            20                  25                  30          

Gly Glu Ile Pro Glu Glu Phe Ser Met Ser Ala Val Asp Met Ser Met 
        35                  40                  45              

Ile Asp His Ile Ser Asp Met Ile Glu Asn Gly Val Asp Ser Leu Lys 
    50                  55                  60                  

Ile Glu Gly Arg Met Glu Ser Ile His Tyr Val Ser Thr Val Thr Asn 
65                  70                  75                  80  

Cys Tyr Lys Ala Ala Val Asp Ala Tyr Leu Glu Ser Pro Glu Lys Phe 
                85                  90                  95      

Glu Ala Ile Lys Gln Asp Leu Val Asp Glu Met Trp Lys Val Ala Gln 
            100                 105                 110         

Arg Glu Leu Ala Thr Gly Phe Tyr Tyr Gly Thr Pro Ser Glu Asn Glu 
        115                 120                 125             

Gln Leu Phe Gly Ala Arg Arg Lys Ile Pro Glu Tyr Lys Phe Val Ala 
    130                 135                 140                 

Glu Val Val Ser Tyr Asp Asp Ala Ala Gln Thr Ala Thr Ile Arg Gln 
145                 150                 155                 160 

Arg Asn Val Ile Asn Glu Gly Asp Gln Val Glu Phe Tyr Gly Pro Gly 
                165                 170                 175     

Phe Arg His Phe Glu Thr Tyr Ile Glu Asp Leu His Asp Ala Lys Gly 
            180                 185                 190         

Asn Lys Ile Asp Arg Ala Pro Asn Pro Met Glu Leu Leu Thr Ile Lys 
        195                 200                 205             

Val Pro Gln Pro Val Gln Ser Gly Asp Met Val Arg Ala Leu Lys Glu 
    210                 215                 220                 

Gly Leu Ile Asn Leu Tyr Lys Glu Asp Gly Thr Ser Val Thr Val Arg 
225                 230                 235                 240 

Ala 
    

<210>   2901
<211>   165
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2901
ttgaacaatc ttgatattat gcgttttatt gtgggaagat ttacttcatt ttctcttgaa   60
attgagtttt ctcctacttc aaaactagat gatttgctat ttaaaatagc gttccttatg   120
attttggcaa cctggattaa agcgagaaaa acaaaagggg caact                   165

<210>   2902
<211>   55
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2902
Met Asn Asn Leu Asp Ile Met Arg Phe Ile Val Gly Arg Phe Thr Ser 
1               5                   10                  15      

Phe Ser Leu Glu Ile Glu Phe Ser Pro Thr Ser Lys Leu Asp Asp Leu 
            20                  25                  30          

Leu Phe Lys Ile Ala Phe Leu Met Ile Leu Ala Thr Trp Ile Lys Ala 
        35                  40                  45              

Arg Lys Thr Lys Gly Ala Thr 
    50                  55  

<210>   2903
<211>   1284
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2903
atgacaaaaa cattaaaacg tcctgaggtt ttatcacctg cagggacttt agagaagcta   60
aaggtagctg ttcagtatgg agcagatgct gtctttatcg gtggtcaggc ctatggtctt   120
cgtagccgtg cgggaaactt tactttcgaa cagatggaag aaggcgtgca gtttgcggcc   180
aagtatggtg ccaaggtcta tgtagcggct aatatggtta tgcacgaagg aaatgaagct   240
ggtgctggtg agtggttccg taaactgcgt gatatcggga ttgcagcagt tatcgtatct   300
gacccagcct tgattatgat tgcagtgact gaagcaccag gccttgaaat ccacctttct   360
acccaagcca gtgccactaa ctatgaaacc cttgagttct ggaaagagct aggcttgact   420
cgtgtcgttt tagcgcgtga ggtttcaatg gaagaattag ctgagatccg caaacgtaca   480
gatgttgaaa ttgaagcctt tgtccatgga gctatgtgta tttcatactc tggacgttgt   540
actctttcaa accacatgag tatgcgtgat gccaaccgtg gtggatgttc tcagtcatgc   600
cgttggaaat acgaccttta cgatatgcca tttgggaaag aacgtaagag tttgcagggt   660
gagattccag aagaattttc aatgtcagcc gttgacatgt ctatgattga ccacattcca   720
gatatgattg aaaatggtgt ggacagtcta aaaatcgaag gacgtatgaa gtctattcac   780
tacgtatcaa cagtaaccaa ctgctacaag gcggctgtgg atgcctatct tgaaagtcct   840
gaaaagtttg aagctatcaa acaagacttg gtggacgaga tgtggaaggt tgcccaacgt   900
gaactggcta caggatttta ctatggtaca ccatctgaaa atgagcagtt gtttggtgct   960
cgccgtaaaa ttcctgagta caagtttgtc gctgaagtgg tttcttatga tgatgcggca   1020
caaacagcaa caattcgtca acgaaatgtc attaacgaag gggaccaagt tgagttttat   1080
ggtccaggtt tccgtcattt tgaaacctat attgaagatt tgcatgatgc caaaggcaat   1140
aaaatcgacc gcgctccaaa tccaatggaa ctattgacta ttaaggtgcc tcaacccgtt   1200
caatcaggag atatggttcg tgcattaaaa gaaggactca tcaatcttta taaggaagat   1260
ggaaccagcg tcacagttcg agct                                          1284

<210>   2904
<211>   428
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidase, U32 family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903327 (0.E+01)

<400>   2904
Met Thr Lys Thr Leu Lys Arg Pro Glu Val Leu Ser Pro Ala Gly Thr 
1               5                   10                  15      

Leu Glu Lys Leu Lys Val Ala Val Gln Tyr Gly Ala Asp Ala Val Phe 
            20                  25                  30          

Ile Gly Gly Gln Ala Tyr Gly Leu Arg Ser Arg Ala Gly Asn Phe Thr 
        35                  40                  45              


Phe Glu Gln Met Glu Glu Gly Val Gln Phe Ala Ala Lys Tyr Gly Ala 
    50                  55                  60                  

Lys Val Tyr Val Ala Ala Asn Met Val Met His Glu Gly Asn Glu Ala 
65                  70                  75                  80  

Gly Ala Gly Glu Trp Phe Arg Lys Leu Arg Asp Ile Gly Ile Ala Ala 
                85                  90                  95      

Val Ile Val Ser Asp Pro Ala Leu Ile Met Ile Ala Val Thr Glu Ala 
            100                 105                 110         

Pro Gly Leu Glu Ile His Leu Ser Thr Gln Ala Ser Ala Thr Asn Tyr 
        115                 120                 125             

Glu Thr Leu Glu Phe Trp Lys Glu Leu Gly Leu Thr Arg Val Val Leu 
    130                 135                 140                 

Ala Arg Glu Val Ser Met Glu Glu Leu Ala Glu Ile Arg Lys Arg Thr 
145                 150                 155                 160 

Asp Val Glu Ile Glu Ala Phe Val His Gly Ala Met Cys Ile Ser Tyr 
                165                 170                 175     

Ser Gly Arg Cys Thr Leu Ser Asn His Met Ser Met Arg Asp Ala Asn 
            180                 185                 190         

Arg Gly Gly Cys Ser Gln Ser Cys Arg Trp Lys Tyr Asp Leu Tyr Asp 
        195                 200                 205             

Met Pro Phe Gly Lys Glu Arg Lys Ser Leu Gln Gly Glu Ile Pro Glu 
    210                 215                 220                 

Glu Phe Ser Met Ser Ala Val Asp Met Ser Met Ile Asp His Ile Pro 
225                 230                 235                 240 

Asp Met Ile Glu Asn Gly Val Asp Ser Leu Lys Ile Glu Gly Arg Met 
                245                 250                 255     

Lys Ser Ile His Tyr Val Ser Thr Val Thr Asn Cys Tyr Lys Ala Ala 
            260                 265                 270         

Val Asp Ala Tyr Leu Glu Ser Pro Glu Lys Phe Glu Ala Ile Lys Gln 
        275                 280                 285             

Asp Leu Val Asp Glu Met Trp Lys Val Ala Gln Arg Glu Leu Ala Thr 
    290                 295                 300                 

Gly Phe Tyr Tyr Gly Thr Pro Ser Glu Asn Glu Gln Leu Phe Gly Ala 
305                 310                 315                 320 

Arg Arg Lys Ile Pro Glu Tyr Lys Phe Val Ala Glu Val Val Ser Tyr 
                325                 330                 335     

Asp Asp Ala Ala Gln Thr Ala Thr Ile Arg Gln Arg Asn Val Ile Asn 
            340                 345                 350         

Glu Gly Asp Gln Val Glu Phe Tyr Gly Pro Gly Phe Arg His Phe Glu 
        355                 360                 365             

Thr Tyr Ile Glu Asp Leu His Asp Ala Lys Gly Asn Lys Ile Asp Arg 
    370                 375                 380                 

Ala Pro Asn Pro Met Glu Leu Leu Thr Ile Lys Val Pro Gln Pro Val 
385                 390                 395                 400 

Gln Ser Gly Asp Met Val Arg Ala Leu Lys Glu Gly Leu Ile Asn Leu 
                405                 410                 415     

Tyr Lys Glu Asp Gly Thr Ser Val Thr Val Arg Ala 
            420                 425             

<210>   2905
<211>   180
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2905
atggcaaatg ataataagag ccattatttg atatacagag ttttaggtat ttcatttgaa   60
gaaggagaaa atatcgattt gtatcaaaat aaaggtcgtt ttttatacaa atatgctggt   120
tcatttttag aagaagctgc agtactatgc tttaacgaaa aatttggtac agaaaatact   180

<210>   2906
<211>   60
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type II restriction endonuclease, putative, POINT MUTATION

<400>   2906
Met Ala Asn Asp Asn Lys Ser His Tyr Leu Ile Tyr Arg Val Leu Gly 
1               5                   10                  15      

Ile Ser Phe Glu Glu Gly Glu Asn Ile Asp Leu Tyr Gln Asn Lys Gly 
            20                  25                  30          

Arg Phe Leu Tyr Lys Tyr Ala Gly Ser Phe Leu Glu Glu Ala Ala Val 
        35                  40                  45              

Leu Cys Phe Asn Glu Lys Phe Gly Thr Glu Asn Thr 
    50                  55                  60  

<210>   2907
<211>   189
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2907
atgttctact atccaaatag aactcaagct ataaaaattc agcaaacttt agaaacattg   60
tataacggta ttggagggaa atattattat ggagattctg cctgggaaca tttaagagca   120
gtgaccggta ttgatttact tagtattcta acagatattg caaataaaaa aacaggggta   180
aaatcaaaa                                                           189

<210>   2908
<211>   63
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   restriction endonuclease R.XbaI

<400>   2908
Met Phe Tyr Tyr Pro Asn Arg Thr Gln Ala Ile Lys Ile Gln Gln Thr 
1               5                   10                  15      

Leu Glu Thr Leu Tyr Asn Gly Ile Gly Gly Lys Tyr Tyr Tyr Gly Asp 
            20                  25                  30          

Ser Ala Trp Glu His Leu Arg Ala Val Thr Gly Ile Asp Leu Leu Ser 
        35                  40                  45              

Ile Leu Thr Asp Ile Ala Asn Lys Lys Thr Gly Val Lys Ser Lys 
    50                  55                  60              

<210>   2909
<211>   1188
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2909
atgacagtat taaaaggaga taacttagaa atattaaaaa ctattgaatc ctcaagtatt   60
gatttaatct atatggaccc tcctttcttt acacagaaaa cccaaaaatt atctaataac   120
aaaaatatta tgtattcatt cgaagatacg tggacttcga ttgaggatta caaagaattt   180
ttgtctgtaa gattagaaga atgcaaaaga gtgctaaaaa atagtggcag tattttcgtt   240
cattgtgata aaattgcaaa tcatcatatt agattaattt tagataatat ctttggagta   300
gatatgtttc aaagcgaaat tatatggaac tataaacggt ggtctaattc aaaaaaggga   360
ttattgaaca atcatcaaaa catttacttt tattcaaagt caaaagattt taaatttaat   420
acaattttta cagagtattc ttctactaca aatatcgacc aaatactagt ggaacgaaaa   480

cgagatggaa actctaaaac tatatataag gttgataata atggtaacta tattctagca   540
aaagagaaaa atggagttcc cctttcagat gtttggaata taccatttct taatccaaaa   600
gctaaagaaa gagtaggtta tcctacacaa aaacctattc tgttattaga acaaattata   660
aagattgcta ctgataaaaa tgatatagtt ttagacccgt tctgtggaag tggaactact   720
ttagtagcct ccaagatttt gaatagaaat tatatgggga ttgatttatc tgaggaagct   780
atcaatataa ctcagcaacg tctggaaaat gttataaaaa caagttcaaa tttattgaat   840
aaaggaatcg aagcatatag aaccaaaact gaggaagagg aaaacattct taaattatta   900
caggcaaaaa ttgttcaaag aaataaagga attgatggtt ttttacctaa acattttcaa   960
aaaaaaccga tacctataaa aattcaaaaa aataatgaat gtctgaatga gagtatctct   1020
ttattacaga atgctataaa ctccaaaaaa cttgattttg gagtagttat aaaaactcat   1080
tcagataatt tattatttga ttttgatacg attcctgaaa atataatagt agttgaccat   1140
tttgaactta caatcgaaaa atggttaagt aaaagtcaac agttacta                1188

<210>   2910
<211>   396
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type II DNA modification methyltransferase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903330 (0.E+01)

<400>   2910
Met Thr Val Leu Lys Gly Asp Asn Leu Glu Ile Leu Lys Thr Ile Glu 
1               5                   10                  15      

Ser Ser Ser Ile Asp Leu Ile Tyr Met Asp Pro Pro Phe Phe Thr Gln 
            20                  25                  30          

Lys Thr Gln Lys Leu Ser Asn Asn Lys Asn Ile Met Tyr Ser Phe Glu 
        35                  40                  45              

Asp Thr Trp Thr Ser Ile Glu Asp Tyr Lys Glu Phe Leu Ser Val Arg 
    50                  55                  60                  

Leu Glu Glu Cys Lys Arg Val Leu Lys Asn Ser Gly Ser Ile Phe Val 
65                  70                  75                  80  

His Cys Asp Lys Ile Ala Asn His His Ile Arg Leu Ile Leu Asp Asn 
                85                  90                  95      

Ile Phe Gly Val Asp Met Phe Gln Ser Glu Ile Ile Trp Asn Tyr Lys 
            100                 105                 110         

Arg Trp Ser Asn Ser Lys Lys Gly Leu Leu Asn Asn His Gln Asn Ile 
        115                 120                 125             

Tyr Phe Tyr Ser Lys Ser Lys Asp Phe Lys Phe Asn Thr Ile Phe Thr 
    130                 135                 140                 

Glu Tyr Ser Ser Thr Thr Asn Ile Asp Gln Ile Leu Val Glu Arg Lys 
145                 150                 155                 160 

Arg Asp Gly Asn Ser Lys Thr Ile Tyr Lys Val Asp Asn Asn Gly Asn 
                165                 170                 175     

Tyr Ile Leu Ala Lys Glu Lys Asn Gly Val Pro Leu Ser Asp Val Trp 
            180                 185                 190         

Asn Ile Pro Phe Leu Asn Pro Lys Ala Lys Glu Arg Val Gly Tyr Pro 
        195                 200                 205             

Thr Gln Lys Pro Ile Leu Leu Leu Glu Gln Ile Ile Lys Ile Ala Thr 
    210                 215                 220                 

Asp Lys Asn Asp Ile Val Leu Asp Pro Phe Cys Gly Ser Gly Thr Thr 
225                 230                 235                 240 

Leu Val Ala Ser Lys Ile Leu Asn Arg Asn Tyr Met Gly Ile Asp Leu 
                245                 250                 255     

Ser Glu Glu Ala Ile Asn Ile Thr Gln Gln Arg Leu Glu Asn Val Ile 
            260                 265                 270         

Lys Thr Ser Ser Asn Leu Leu Asn Lys Gly Ile Glu Ala Tyr Arg Thr 
        275                 280                 285             

Lys Thr Glu Glu Glu Glu Asn Ile Leu Lys Leu Leu Gln Ala Lys Ile 
    290                 295                 300                 

Val Gln Arg Asn Lys Gly Ile Asp Gly Phe Leu Pro Lys His Phe Gln 
305                 310                 315                 320 

Lys Lys Pro Ile Pro Ile Lys Ile Gln Lys Asn Asn Glu Cys Leu Asn 
                325                 330                 335     

Glu Ser Ile Ser Leu Leu Gln Asn Ala Ile Asn Ser Lys Lys Leu Asp 
            340                 345                 350         

Phe Gly Val Val Ile Lys Thr His Ser Asp Asn Leu Leu Phe Asp Phe 
        355                 360                 365             

Asp Thr Ile Pro Glu Asn Ile Ile Val Val Asp His Phe Glu Leu Thr 
    370                 375                 380                 

Ile Glu Lys Trp Leu Ser Lys Ser Gln Gln Leu Leu 
385                 390                 395     

<210>   2911
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2911
ttgtcttcta agctcttaaa agcaaaagaa caagtaaaga gtcaagacaa ggataaaaag   60
tccatattag ggcaaataaa aagctttaag acagatgaca aatctaagtc aaataagaaa   120
gaccatagca aaggtgcaga gaga                                          144

<210>   2912
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2912
Met Ser Ser Lys Leu Leu Lys Ala Lys Glu Gln Val Lys Ser Gln Asp 
1               5                   10                  15      

Lys Asp Lys Lys Ser Ile Leu Gly Gln Ile Lys Ser Phe Lys Thr Asp 
            20                  25                  30          

Asp Lys Ser Lys Ser Asn Lys Lys Asp His Ser Lys Gly Ala Glu Arg 
        35                  40                  45              


<210>   2913
<211>   990
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2913
atgtcatatt atgattttgt aaaagattat atgaaagtag atgaatgtaa aaacaatgag   60
aagtattcaa gtgcaggtca tacattttgt tggaaaaaag agaattcaac ttatgcagaa   120
ggactatatt ggttttatga aggaggcagc ttcattatcg atatacatga tttttatatc   180
aaagaggaag tagttcaaaa tagcacttat agtatgtcag actatgtttc aatttattca   240
agttacattg tcagtgcaaa cggagaaaag tttaatccgt atcaaactat taccgcaaac   300
tctctatgta cttttgattt tgataatata aaagataatt ttgttttttt attacacgag   360
aattgttgtt atcttgctgt ttccattggt tttaaaaaag agctaataga aaaacattta   420
gcatctatta acattaatcc agaatctttt tattcaacct tgcttcaacc gaatcaaata   480
atacttacaa aggccttaga aagagtggca atggaaatat taaattgtaa gatggacgct   540
cctgccgctg attttttctt taaagcaaag gcaaatgaat ggataagtat agtaattgac   600
acatacttaa atagaaaaaa atataaaatt gaaattgatg atgataaagc acttgaagat   660
gtagcaagat tcttagatga tcattttgca acgaatgtaa atcaaggcac gcttgaaaaa   720
atatctaaaa tgagtggtac taaattaaaa aatttattta aggaaaaata ttgtcaaagc   780
attacagagt acactcaaag aaaaagaatg aatgtagctg aaactcttct tttaaacact   840
gaactaccta taaaagagat agcagaatct gttggatatt catctgccag caaattttct   900
atctattata aaagatacaa gggaaaactt ccaagtgaag tccgtaattt agcttgcaaa   960
catcacaatt ttaaatgcga ttattgtgat                                    990

<210>   2914
<211>   330
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, araC family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903331 (0.E+01)

<400>   2914
Met Ser Tyr Tyr Asp Phe Val Lys Asp Tyr Met Lys Val Asp Glu Cys 
1               5                   10                  15      

Lys Asn Asn Glu Lys Tyr Ser Ser Ala Gly His Thr Phe Cys Trp Lys 
            20                  25                  30          

Lys Glu Asn Ser Thr Tyr Ala Glu Gly Leu Tyr Trp Phe Tyr Glu Gly 
        35                  40                  45              

Gly Ser Phe Ile Ile Asp Ile His Asp Phe Tyr Ile Lys Glu Glu Val 
    50                  55                  60                  

Val Gln Asn Ser Thr Tyr Ser Met Ser Asp Tyr Val Ser Ile Tyr Ser 
65                  70                  75                  80  

Ser Tyr Ile Val Ser Ala Asn Gly Glu Lys Phe Asn Pro Tyr Gln Thr 
                85                  90                  95      

Ile Thr Ala Asn Ser Leu Cys Thr Phe Asp Phe Asp Asn Ile Lys Asp 
            100                 105                 110         

Asn Phe Val Phe Leu Leu His Glu Asn Cys Cys Tyr Leu Ala Val Ser 
        115                 120                 125             

Ile Gly Phe Lys Lys Glu Leu Ile Glu Lys His Leu Ala Ser Ile Asn 
    130                 135                 140                 

Ile Asn Pro Glu Ser Phe Tyr Ser Thr Leu Leu Gln Pro Asn Gln Ile 
145                 150                 155                 160 

Ile Leu Thr Lys Ala Leu Glu Arg Val Ala Met Glu Ile Leu Asn Cys 
                165                 170                 175     

Lys Met Asp Ala Pro Ala Ala Asp Phe Phe Phe Lys Ala Lys Ala Asn 
            180                 185                 190         

Glu Trp Ile Ser Ile Val Ile Asp Thr Tyr Leu Asn Arg Lys Lys Tyr 
        195                 200                 205             

Lys Ile Glu Ile Asp Asp Asp Lys Ala Leu Glu Asp Val Ala Arg Phe 
    210                 215                 220                 

Leu Asp Asp His Phe Ala Thr Asn Val Asn Gln Gly Thr Leu Glu Lys 
225                 230                 235                 240 

Ile Ser Lys Met Ser Gly Thr Lys Leu Lys Asn Leu Phe Lys Glu Lys 
                245                 250                 255     

Tyr Cys Gln Ser Ile Thr Glu Tyr Thr Gln Arg Lys Arg Met Asn Val 
            260                 265                 270         


Ala Glu Thr Leu Leu Leu Asn Thr Glu Leu Pro Ile Lys Glu Ile Ala 
        275                 280                 285             

Glu Ser Val Gly Tyr Ser Ser Ala Ser Lys Phe Ser Ile Tyr Tyr Lys 
    290                 295                 300                 

Arg Tyr Lys Gly Lys Leu Pro Ser Glu Val Arg Asn Leu Ala Cys Lys 
305                 310                 315                 320 

His His Asn Phe Lys Cys Asp Tyr Cys Asp 
                325                 330 

<210>   2915
<211>   1758
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2915
atgcttatga agatttacaa aaaactattt gcttatgtcc aagataagaa atatcttggg   60
gttttggcca taattttttc tgctatatct gctgcactta cagtatatgg atattattta   120
atctacaaat ttctagataa gttaataatt aattcaaact tatccggtgc agagagtata   180
gcattaaaat ctgttattac actaacaagt ggagcgatat tttattttgt ctcaggaatg   240
ttttcacata tcttgggatt caggcttgaa acaaatttaa gaaaaagggg aatcgatggt   300
ctggaaaaag caagttttag gttctttgac ttaaatccat ctggtcaaat aagaaagatt   360
atagatgaca atgctgcaca aactcatcag gtggtagcac acatgattcc cgatagttct   420
caggcaataa tcacacccgt acttgtactt gcacttggct ttatagtaag tataagagtt   480
ggcataattt tgcttgctct tactataatt ggtggcttaa ttttaggggc aatgatgggc   540
gagcaagaat ttatgaagat ataccaagaa tccctatcta aactaagtgc tgaaactgtt   600
gagtacgtga gaggaatgca agttgtaaaa atatttaaag caaatgtaga gtcttttaaa   660
agcttttata aggcgataaa agattactca aagtatgctt atgattattc cctatcttgt   720
aaaaggcctt atgttttgta tcaatggtta ttttttggac tgattgcaat tttaattatt   780
cctatagttt attttatgac tagcttagct agcgcaaagg tgattttact tgagcttatc   840
atgattttat ttttatcagg agttctcttt gtttcattca tgagaatgat gtggtactcc   900
atgtatattt ctcaaggaaa ttatgcagta gatactttag aggcgcttta cgaagatatg   960
caaaaagaca aattagtgca tggtaatgtc aataatttta aaaactataa tatagaattt   1020
gagaatgtta gctttgctta taatgataaa gctgtcattg aaaatttatc ctttaattta   1080
gaagaaggaa agtcctacgc acttgtcggt tcatctggat caggcaaatc aacagtagca   1140
aaacttatat caggttttta caatgttaat aaaggaagca taaagatagg cgggatagca   1200
ataagtgaat attctgacga agccttaatt aaagccattt cctttgtttt tcaagattca   1260
aaattattca agaagagcat ttatgataat gtagcgttag ctaataaaga tgcgacgaaa   1320
gatgacgtta tgagagcctt aaaattagca ggatgcgatt taatattaga caaattccca   1380
gaaagagaaa atacaatcat aggctcaaaa ggtgtttatt tatccggtgg agaaaaacaa   1440
agaattgcaa ttgctagagc aattttaaag gattccaaaa ttattattat ggatgaagca   1500
tcagcatcta ttgacccaga taacgagttt gaattgcaaa aagcttttaa aaatcttatg   1560
aaggataaaa cagttatcat gattgcacac aggctatcta caattaaaga ccttgatgaa   1620

attattgtca tggatagtgg aaaaattata gaaagagggt ctgacaaaga attaatgtca   1680
aaagatacaa ggtataagag cctgcaagag atgtttaaca gtgcgaatga atggagggtt   1740
tcaaatgaaa gagtttta                                                 1758

<210>   2916
<211>   586
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903332 (0.E+01)

<400>   2916
Met Leu Met Lys Ile Tyr Lys Lys Leu Phe Ala Tyr Val Gln Asp Lys 
1               5                   10                  15      


Lys Tyr Leu Gly Val Leu Ala Ile Ile Phe Ser Ala Ile Ser Ala Ala 
            20                  25                  30          

Leu Thr Val Tyr Gly Tyr Tyr Leu Ile Tyr Lys Phe Leu Asp Lys Leu 
        35                  40                  45              

Ile Ile Asn Ser Asn Leu Ser Gly Ala Glu Ser Ile Ala Leu Lys Ser 
    50                  55                  60                  

Val Ile Thr Leu Thr Ser Gly Ala Ile Phe Tyr Phe Val Ser Gly Met 
65                  70                  75                  80  

Phe Ser His Ile Leu Gly Phe Arg Leu Glu Thr Asn Leu Arg Lys Arg 
                85                  90                  95      

Gly Ile Asp Gly Leu Glu Lys Ala Ser Phe Arg Phe Phe Asp Leu Asn 
            100                 105                 110         

Pro Ser Gly Gln Ile Arg Lys Ile Ile Asp Asp Asn Ala Ala Gln Thr 
        115                 120                 125             

His Gln Val Val Ala His Met Ile Pro Asp Ser Ser Gln Ala Ile Ile 
    130                 135                 140                 

Thr Pro Val Leu Val Leu Ala Leu Gly Phe Ile Val Ser Ile Arg Val 
145                 150                 155                 160 

Gly Ile Ile Leu Leu Ala Leu Thr Ile Ile Gly Gly Leu Ile Leu Gly 
                165                 170                 175     

Ala Met Met Gly Glu Gln Glu Phe Met Lys Ile Tyr Gln Glu Ser Leu 
            180                 185                 190         

Ser Lys Leu Ser Ala Glu Thr Val Glu Tyr Val Arg Gly Met Gln Val 
        195                 200                 205             

Val Lys Ile Phe Lys Ala Asn Val Glu Ser Phe Lys Ser Phe Tyr Lys 
    210                 215                 220                 

Ala Ile Lys Asp Tyr Ser Lys Tyr Ala Tyr Asp Tyr Ser Leu Ser Cys 
225                 230                 235                 240 

Lys Arg Pro Tyr Val Leu Tyr Gln Trp Leu Phe Phe Gly Leu Ile Ala 
                245                 250                 255     

Ile Leu Ile Ile Pro Ile Val Tyr Phe Met Thr Ser Leu Ala Ser Ala 
            260                 265                 270         

Lys Val Ile Leu Leu Glu Leu Ile Met Ile Leu Phe Leu Ser Gly Val 
        275                 280                 285             

Leu Phe Val Ser Phe Met Arg Met Met Trp Tyr Ser Met Tyr Ile Ser 
    290                 295                 300                 

Gln Gly Asn Tyr Ala Val Asp Thr Leu Glu Ala Leu Tyr Glu Asp Met 
305                 310                 315                 320 

Gln Lys Asp Lys Leu Val His Gly Asn Val Asn Asn Phe Lys Asn Tyr 
                325                 330                 335     

Asn Ile Glu Phe Glu Asn Val Ser Phe Ala Tyr Asn Asp Lys Ala Val 
            340                 345                 350         

Ile Glu Asn Leu Ser Phe Asn Leu Glu Glu Gly Lys Ser Tyr Ala Leu 
        355                 360                 365             

Val Gly Ser Ser Gly Ser Gly Lys Ser Thr Val Ala Lys Leu Ile Ser 
    370                 375                 380                 

Gly Phe Tyr Asn Val Asn Lys Gly Ser Ile Lys Ile Gly Gly Ile Ala 
385                 390                 395                 400 

Ile Ser Glu Tyr Ser Asp Glu Ala Leu Ile Lys Ala Ile Ser Phe Val 
                405                 410                 415     

Phe Gln Asp Ser Lys Leu Phe Lys Lys Ser Ile Tyr Asp Asn Val Ala 
            420                 425                 430         

Leu Ala Asn Lys Asp Ala Thr Lys Asp Asp Val Met Arg Ala Leu Lys 
        435                 440                 445             

Leu Ala Gly Cys Asp Leu Ile Leu Asp Lys Phe Pro Glu Arg Glu Asn 
    450                 455                 460                 

Thr Ile Ile Gly Ser Lys Gly Val Tyr Leu Ser Gly Gly Glu Lys Gln 
465                 470                 475                 480 

Arg Ile Ala Ile Ala Arg Ala Ile Leu Lys Asp Ser Lys Ile Ile Ile 
                485                 490                 495     

Met Asp Glu Ala Ser Ala Ser Ile Asp Pro Asp Asn Glu Phe Glu Leu 
            500                 505                 510         

Gln Lys Ala Phe Lys Asn Leu Met Lys Asp Lys Thr Val Ile Met Ile 
        515                 520                 525             

Ala His Arg Leu Ser Thr Ile Lys Asp Leu Asp Glu Ile Ile Val Met 
    530                 535                 540                 

Asp Ser Gly Lys Ile Ile Glu Arg Gly Ser Asp Lys Glu Leu Met Ser 
545                 550                 555                 560 

Lys Asp Thr Arg Tyr Lys Ser Leu Gln Glu Met Phe Asn Ser Ala Asn 
                565                 570                 575     

Glu Trp Arg Val Ser Asn Glu Arg Val Leu 
            580                 585     

<210>   2917
<211>   1743
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2917
gtgcgaatga atggagggtt tcaaatgaaa gagttttata aaaaaagatt tgctcttaca   60
gatggaggag caagaaattt aagtaaagca acactggctt catttttcgt ttattgtata   120
aacatgcttc ctgccatatt acttatgatt tttgctcagg aagttttgga aaatatgggc   180
aaaagcaatg gcttttatat agtattctca gttttgattt tgatagcaat gtatattttg   240
ctttctatcg aatacgataa attatataac acaacctatc aagaaagtgc agatttaaga   300
ataaggacag cggagaattt atcaaaatta cctctatctt acttttctaa acatgacatt   360
tccgacattt cacaaacaat catggctgat attgaaggca tagagcatgc aatgagccac   420
tcaataccaa aggtgggcgg catggtactg tttttcccat taatatctgt aatgatgcta   480
gcgggcaatg tcaagatggg tttagctgta attattccat ctattttaag ctttatattt   540
atacctttat ctaaaaaata tcaggttaat ggacagaata gatattatga tgtcttaaga   600
aaaaactcag aaagctttca agaaaatatc gaaatgcaaa tggagattaa agcatataat   660
ttatcgaagg atattaaaga tgacttatat aaaaaaatgg aagatagtga gaaagtacac   720
ttaaaggcgg aagtaactac aattttaact ttgtctatat cttcaatatt tagctttata   780
tctcttgctg ttgtgatatt tgtcggcgta aatctaatta ttaataaaga gataaattct   840

ctctacctta taggatattt actagctgct atgaagataa aagactcttt agatgcatct   900
aaagagggct tgatggaaat attttattta tcgcccaaaa tagaaagatt aaaagaaatt   960
caaaatcaag atttacaaga aggcgatgac tatagcttaa aaaaatttga tattgatcta   1020
aaagatgttg agtttgccta caataaagac gcaaaagttt taaatggtgt aagttttaaa   1080
gctaagcagg gagaggtcac tgctttggta ggtgcaagtg gctgcggtaa aacaactatc   1140
ttgaaactta tatcaagact ttatgattat gacaagggac aaatcttaat cgatggcaaa   1200
gatataaagg aaatatcaac agaatccctt tttgataagg tgtctattgt tttccaagat   1260
gtggttctct ttaatcaaag cgttatggaa aatattagaa tcggtaagca agatgcaagt   1320
gacgaagagg ttaaaagagc agcaaaactt gcaaattgca cagattttat agaaaaaatg   1380
gataaaggtt tcgatacagt tattggtgaa aacggagctg agctatcagg aggagaaaga   1440
caaagattat caatagccag agccttctta aaagatgcgc cgatattgat cttagatgag   1500
ataacagcaa gccttgatgt taacaacgag aaaaagattc aagagtcttt aaataattta   1560
gttaaagata aaactgttgt aatcatttca catagaatga aatccataga aaatgcagac   1620
aagatagtag ttcttcaaaa cggaagagta gaaagcgaag gtaagcatga agagctttta   1680
caaaaatcaa aaatttacaa aaatttaata gaaaagacaa aaatggcaga agaatttatt   1740
tat                                                                 1743

<210>   2918
<211>   581
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903333 (0.E+01)

<400>   2918
Met Arg Met Asn Gly Gly Phe Gln Met Lys Glu Phe Tyr Lys Lys Arg 
1               5                   10                  15      

Phe Ala Leu Thr Asp Gly Gly Ala Arg Asn Leu Ser Lys Ala Thr Leu 
            20                  25                  30          

Ala Ser Phe Phe Val Tyr Cys Ile Asn Met Leu Pro Ala Ile Leu Leu 
        35                  40                  45              

Met Ile Phe Ala Gln Glu Val Leu Glu Asn Met Gly Lys Ser Asn Gly 
    50                  55                  60                  

Phe Tyr Ile Val Phe Ser Val Leu Ile Leu Ile Ala Met Tyr Ile Leu 
65                  70                  75                  80  

Leu Ser Ile Glu Tyr Asp Lys Leu Tyr Asn Thr Thr Tyr Gln Glu Ser 
                85                  90                  95      

Ala Asp Leu Arg Ile Arg Thr Ala Glu Asn Leu Ser Lys Leu Pro Leu 
            100                 105                 110         

Ser Tyr Phe Ser Lys His Asp Ile Ser Asp Ile Ser Gln Thr Ile Met 
        115                 120                 125             

Ala Asp Ile Glu Gly Ile Glu His Ala Met Ser His Ser Ile Pro Lys 
    130                 135                 140                 

Val Gly Gly Met Val Leu Phe Phe Pro Leu Ile Ser Val Met Met Leu 
145                 150                 155                 160 

Ala Gly Asn Val Lys Met Gly Leu Ala Val Ile Ile Pro Ser Ile Leu 
                165                 170                 175     

Ser Phe Ile Phe Ile Pro Leu Ser Lys Lys Tyr Gln Val Asn Gly Gln 
            180                 185                 190         

Asn Arg Tyr Tyr Asp Val Leu Arg Lys Asn Ser Glu Ser Phe Gln Glu 
        195                 200                 205             

Asn Ile Glu Met Gln Met Glu Ile Lys Ala Tyr Asn Leu Ser Lys Asp 
    210                 215                 220                 

Ile Lys Asp Asp Leu Tyr Lys Lys Met Glu Asp Ser Glu Lys Val His 
225                 230                 235                 240 

Leu Lys Ala Glu Val Thr Thr Ile Leu Thr Leu Ser Ile Ser Ser Ile 
                245                 250                 255     

Phe Ser Phe Ile Ser Leu Ala Val Val Ile Phe Val Gly Val Asn Leu 
            260                 265                 270         

Ile Ile Asn Lys Glu Ile Asn Ser Leu Tyr Leu Ile Gly Tyr Leu Leu 
        275                 280                 285             

Ala Ala Met Lys Ile Lys Asp Ser Leu Asp Ala Ser Lys Glu Gly Leu 
    290                 295                 300                 

Met Glu Ile Phe Tyr Leu Ser Pro Lys Ile Glu Arg Leu Lys Glu Ile 
305                 310                 315                 320 

Gln Asn Gln Asp Leu Gln Glu Gly Asp Asp Tyr Ser Leu Lys Lys Phe 
                325                 330                 335     

Asp Ile Asp Leu Lys Asp Val Glu Phe Ala Tyr Asn Lys Asp Ala Lys 
            340                 345                 350         

Val Leu Asn Gly Val Ser Phe Lys Ala Lys Gln Gly Glu Val Thr Ala 
        355                 360                 365             

Leu Val Gly Ala Ser Gly Cys Gly Lys Thr Thr Ile Leu Lys Leu Ile 
    370                 375                 380                 

Ser Arg Leu Tyr Asp Tyr Asp Lys Gly Gln Ile Leu Ile Asp Gly Lys 
385                 390                 395                 400 

Asp Ile Lys Glu Ile Ser Thr Glu Ser Leu Phe Asp Lys Val Ser Ile 
                405                 410                 415     

Val Phe Gln Asp Val Val Leu Phe Asn Gln Ser Val Met Glu Asn Ile 
            420                 425                 430         

Arg Ile Gly Lys Gln Asp Ala Ser Asp Glu Glu Val Lys Arg Ala Ala 
        435                 440                 445             

Lys Leu Ala Asn Cys Thr Asp Phe Ile Glu Lys Met Asp Lys Gly Phe 
    450                 455                 460                 

Asp Thr Val Ile Gly Glu Asn Gly Ala Glu Leu Ser Gly Gly Glu Arg 
465                 470                 475                 480 

Gln Arg Leu Ser Ile Ala Arg Ala Phe Leu Lys Asp Ala Pro Ile Leu 
                485                 490                 495     

Ile Leu Asp Glu Ile Thr Ala Ser Leu Asp Val Asn Asn Glu Lys Lys 
            500                 505                 510         

Ile Gln Glu Ser Leu Asn Asn Leu Val Lys Asp Lys Thr Val Val Ile 
        515                 520                 525             

Ile Ser His Arg Met Lys Ser Ile Glu Asn Ala Asp Lys Ile Val Val 
    530                 535                 540                 

Leu Gln Asn Gly Arg Val Glu Ser Glu Gly Lys His Glu Glu Leu Leu 
545                 550                 555                 560 

Gln Lys Ser Lys Ile Tyr Lys Asn Leu Ile Glu Lys Thr Lys Met Ala 
                565                 570                 575     

Glu Glu Phe Ile Tyr 
            580     

<210>   2919
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2919
atggataata aaaaattaaa agtaaaagat ttagtaagca tcggtgtttt tggcgtaatt   60
tattttgcct tcatgtttgg agttggtatg atgggcttga ttccaatatt gttcttaata   120
tacccgacag tattagccat agttgcagga actgttgtta tgttatttat ggctaaggtt   180
caaaagccat gggcactatt tatatttggt atgatatcac cacttgtgat gtttgcagct   240
ggtcatacct acgtagttgt ggttttatca cttatagtaa tgataatagc agaattaatt   300
agaaagattg gtaattataa ttcatttaaa tacaatatgc tttcttatgc aatcttcagc   360
acatggatat gtagctcttt aatgcaaatg cttttagcaa aagaaaaata tatggagtgg   420
tctttgatga ctatgggaaa agattatgtt gatgtattag aaaagttaat aacttatcct   480
cacatggctt tagtagcctt aggtgctttc ttaggaggaa ttcttggagc atatataggc   540
aaggctctat tgaaaaaaca cttttcaaat ggattatatt gtgtgggata ctttactcct   600
tgcctaattt tatggtgcta tctgaat                                       627

<210>   2920
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903334 (e-104)

<400>   2920
Met Asp Asn Lys Lys Leu Lys Val Lys Asp Leu Val Ser Ile Gly Val 
1               5                   10                  15      

Phe Gly Val Ile Tyr Phe Ala Phe Met Phe Gly Val Gly Met Met Gly 
            20                  25                  30          

Leu Ile Pro Ile Leu Phe Leu Ile Tyr Pro Thr Val Leu Ala Ile Val 
        35                  40                  45              

Ala Gly Thr Val Val Met Leu Phe Met Ala Lys Val Gln Lys Pro Trp 
    50                  55                  60                  

Ala Leu Phe Ile Phe Gly Met Ile Ser Pro Leu Val Met Phe Ala Ala 
65                  70                  75                  80  

Gly His Thr Tyr Val Val Val Val Leu Ser Leu Ile Val Met Ile Ile 
                85                  90                  95      

Ala Glu Leu Ile Arg Lys Ile Gly Asn Tyr Asn Ser Phe Lys Tyr Asn 
            100                 105                 110         

Met Leu Ser Tyr Ala Ile Phe Ser Thr Trp Ile Cys Ser Ser Leu Met 
        115                 120                 125             

Gln Met Leu Leu Ala Lys Glu Lys Tyr Met Glu Trp Ser Leu Met Thr 
    130                 135                 140                 

Met Gly Lys Asp Tyr Val Asp Val Leu Glu Lys Leu Ile Thr Tyr Pro 
145                 150                 155                 160 

His Met Ala Leu Val Ala Leu Gly Ala Phe Leu Gly Gly Ile Leu Gly 
                165                 170                 175     

Ala Tyr Ile Gly Lys Ala Leu Leu Lys Lys His Phe Ser Asn Gly Leu 
            180                 185                 190         

Tyr Cys Val Gly Tyr Phe Thr Pro Cys Leu Ile Leu Trp Cys Tyr Leu 
        195                 200                 205             

Asn 
    

<210>   2921
<211>   441
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2921
atgtttttga gtatacctat tgttattaga atgtttattt taccatttat ggcagcaagc   60
tttatgataa agacctcgga tgtaggcgca ataatttcat cgatggataa gcttaagatt   120
tcaaagaatg tatccatacc tattgcggtt atgtttagat tcttcccatc ttttaaggag   180
gagaagaaaa acatcaaaat ggctatgaga gtaagaggga taaattttaa aaacccagtc   240
aaatatcttg aatatgtttc tgtgccacta ctcattatat catctaatat atcagatgac   300
attgcaaaag cggcagaaac aaaggcaata gaaaatccaa ttgccaagac cagatacatt   360
cgcgtaaaga tacagctaat tgattttgtt tatgttttag cggttgctgg acttattgtg   420
ggaggcttaa tatggttgaa a                                             441

<210>   2922
<211>   147
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903335 (1.E-76)

<400>   2922
Met Phe Leu Ser Ile Pro Ile Val Ile Arg Met Phe Ile Leu Pro Phe 
1               5                   10                  15      

Met Ala Ala Ser Phe Met Ile Lys Thr Ser Asp Val Gly Ala Ile Ile 
            20                  25                  30          

Ser Ser Met Asp Lys Leu Lys Ile Ser Lys Asn Val Ser Ile Pro Ile 
        35                  40                  45              

Ala Val Met Phe Arg Phe Phe Pro Ser Phe Lys Glu Glu Lys Lys Asn 
    50                  55                  60                  

Ile Lys Met Ala Met Arg Val Arg Gly Ile Asn Phe Lys Asn Pro Val 
65                  70                  75                  80  

Lys Tyr Leu Glu Tyr Val Ser Val Pro Leu Leu Ile Ile Ser Ser Asn 
                85                  90                  95      

Ile Ser Asp Asp Ile Ala Lys Ala Ala Glu Thr Lys Ala Ile Glu Asn 
            100                 105                 110         

Pro Ile Ala Lys Thr Arg Tyr Ile Arg Val Lys Ile Gln Leu Ile Asp 
        115                 120                 125             

Phe Val Tyr Val Leu Ala Val Ala Gly Leu Ile Val Gly Gly Leu Ile 
    130                 135                 140                 

Trp Leu Lys 
145         

<210>   2923
<211>   1122
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2923
atggttgaaa taaaaaattt aagtcttgat tatggtgaag agcatatatt agatgatata   60
tcactatcca tagccgaggg agagtgcgtg ctatttacag gaaaaagtgg aaatggtaag   120
tcatctttaa taaattcaat caatggacta gctgtaaggt atgataacgc aaagacaaag   180
ggcgaaataa ttattgatgg taagaatata aaaaatttgg aactttatca aatctcaatg   240
cttgtttcaa ctgtttttca aaatcctaag acatattttt ttaatgtcaa tacgacatta   300
gaattattat tttatttgga aaatatcggt cttgcaagag aagagatgga caggcgtttg   360
aaggatatac ttgagatatt cccgataaaa aatcttttga acagaaatat atttaatcta   420
tccggcggtg aaaaacaaat tctttgcatt gcagcttctt atatagcagg tacaaagatt   480
atagttatgg atgagccttc atcgaattta gatattaaaa gcataagtgt tttggcaaag   540
atgctaaaga tattaaaaga gaaaggcata agcataattg ttgcagagca tagaatttat   600
tatttgatgg acatagttga ccgtgtattt ttaatagata aaggaaagct taaaaaaact   660
tatactagaa gtgaattttt aaagctagat aaaaatgaat taaatgcttt aagtttaaga   720
gataaagaat taagtaaatt aaaagttcct tatttaaaag aaggtggaga gtatcagata   780
aaaaatctta gttacaaatt tactgatgat gagtgtttaa gcttaaaaga tatttcgttc   840
aagcttggga aaatttatgg cataatagga tccaacggac gaggaaaatc aacgctttta   900
agatgtttaa taggtcttga gaaaaaatca aaagaagaaa tttattttaa gggagagaag   960
ctatctaaaa aagaaagact caaaaactct tcacttgtta tgcaagatgt aaatcatcaa   1020
ttattcacag atgaagtatt caacgagctt agattaggag taaagaattt tgatgaagaa   1080
aaggcgaaaa tcattttaaa ccccaattat tcaccccaaa tc                      1122

<210>   2924
<211>   374
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903336 (0.E+01)

<400>   2924
Met Val Glu Ile Lys Asn Leu Ser Leu Asp Tyr Gly Glu Glu His Ile 
1               5                   10                  15      

Leu Asp Asp Ile Ser Leu Ser Ile Ala Glu Gly Glu Cys Val Leu Phe 
            20                  25                  30          

Thr Gly Lys Ser Gly Asn Gly Lys Ser Ser Leu Ile Asn Ser Ile Asn 
        35                  40                  45              

Gly Leu Ala Val Arg Tyr Asp Asn Ala Lys Thr Lys Gly Glu Ile Ile 
    50                  55                  60                  

Ile Asp Gly Lys Asn Ile Lys Asn Leu Glu Leu Tyr Gln Ile Ser Met 
65                  70                  75                  80  

Leu Val Ser Thr Val Phe Gln Asn Pro Lys Thr Tyr Phe Phe Asn Val 
                85                  90                  95      

Asn Thr Thr Leu Glu Leu Leu Phe Tyr Leu Glu Asn Ile Gly Leu Ala 
            100                 105                 110         

Arg Glu Glu Met Asp Arg Arg Leu Lys Asp Ile Leu Glu Ile Phe Pro 
        115                 120                 125             

Ile Lys Asn Leu Leu Asn Arg Asn Ile Phe Asn Leu Ser Gly Gly Glu 
    130                 135                 140                 

Lys Gln Ile Leu Cys Ile Ala Ala Ser Tyr Ile Ala Gly Thr Lys Ile 
145                 150                 155                 160 

Ile Val Met Asp Glu Pro Ser Ser Asn Leu Asp Ile Lys Ser Ile Ser 
                165                 170                 175     

Val Leu Ala Lys Met Leu Lys Ile Leu Lys Glu Lys Gly Ile Ser Ile 
            180                 185                 190         

Ile Val Ala Glu His Arg Ile Tyr Tyr Leu Met Asp Ile Val Asp Arg 
        195                 200                 205             

Val Phe Leu Ile Asp Lys Gly Lys Leu Lys Lys Thr Tyr Thr Arg Ser 
    210                 215                 220                 

Glu Phe Leu Lys Leu Asp Lys Asn Glu Leu Asn Ala Leu Ser Leu Arg 
225                 230                 235                 240 

Asp Lys Glu Leu Ser Lys Leu Lys Val Pro Tyr Leu Lys Glu Gly Gly 
                245                 250                 255     

Glu Tyr Gln Ile Lys Asn Leu Ser Tyr Lys Phe Thr Asp Asp Glu Cys 
            260                 265                 270         

Leu Ser Leu Lys Asp Ile Ser Phe Lys Leu Gly Lys Ile Tyr Gly Ile 
        275                 280                 285             

Ile Gly Ser Asn Gly Arg Gly Lys Ser Thr Leu Leu Arg Cys Leu Ile 
    290                 295                 300                 

Gly Leu Glu Lys Lys Ser Lys Glu Glu Ile Tyr Phe Lys Gly Glu Lys 
305                 310                 315                 320 

Leu Ser Lys Lys Glu Arg Leu Lys Asn Ser Ser Leu Val Met Gln Asp 
                325                 330                 335     

Val Asn His Gln Leu Phe Thr Asp Glu Val Phe Asn Glu Leu Arg Leu 
            340                 345                 350         

Gly Val Lys Asn Phe Asp Glu Glu Lys Ala Lys Ile Ile Leu Asn Pro 
        355                 360                 365             

Asn Tyr Ser Pro Gln Ile 
    370                 

<210>   2925
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2925
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattgtt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg tgggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   2926
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903941 (2.E-46)

<400>   2926
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 

                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   2927
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2927
atgagtttat caggagggca aaagcaaagg cttgcaatag catctgttat gtgcaagaat   60
tctccatttg tcttttttga cgaaccttca agtggtatgg attattccaa tatgataaaa   120
atatctgaac tgattaataa gtataaaacc atggataaaa taatttttat tgtttcccat   180
gatatagaat ttttaaatga agtggcagat gaaatttttg aattg                   225

<210>   2928
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein, fragment
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   2928
Met Ser Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala Ile Ala Ser Val 
1               5                   10                  15      

Met Cys Lys Asn Ser Pro Phe Val Phe Phe Asp Glu Pro Ser Ser Gly 
            20                  25                  30          

Met Asp Tyr Ser Asn Met Ile Lys Ile Ser Glu Leu Ile Asn Lys Tyr 
        35                  40                  45              

Lys Thr Met Asp Lys Ile Ile Phe Ile Val Ser His Asp Ile Glu Phe 
    50                  55                  60                  

Leu Asn Glu Val Ala Asp Glu Ile Phe Glu Leu 
65                  70                  75  

<210>   2929
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2929
ttggtaaact gcgaacagct agaagcttat cgtcaactgg aagaagctgc acttgttgga   60
tgttgggcgc atgtgagaag gaagtttttt gaagtgcccc ccaagcaagc agataaatca   120
tccttaggag ctaaaggttt agcttattgt gatcagttat tttccttgga aagagactgg   180
gaggctttgc cagctgatga acgactacag aaacgtcaag aacatctcca gcccctaatg   240
gaagacttct ttgcttggtg ccgccgtcag tcagttttag caggttcaaa actaggaagg   300
gcaattgaat acagcctcaa gtatgaagaa acctttaaga ctattttgaa agacggacat   360
ctggtccttt ccaataatct agctgaacgc gccattaaat cattggttat gggacggagt   420
aaaagagtcc agtggactct tttagcc                                       447

<210>   2930
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein

<400>   2930
Met Val Asn Cys Glu Gln Leu Glu Ala Tyr Arg Gln Leu Glu Glu Ala 
1               5                   10                  15      

Ala Leu Val Gly Cys Trp Ala His Val Arg Arg Lys Phe Phe Glu Val 
            20                  25                  30          

Pro Pro Lys Gln Ala Asp Lys Ser Ser Leu Gly Ala Lys Gly Leu Ala 
        35                  40                  45              

Tyr Cys Asp Gln Leu Phe Ser Leu Glu Arg Asp Trp Glu Ala Leu Pro 
    50                  55                  60                  

Ala Asp Glu Arg Leu Gln Lys Arg Gln Glu His Leu Gln Pro Leu Met 
65                  70                  75                  80  

Glu Asp Phe Phe Ala Trp Cys Arg Arg Gln Ser Val Leu Ala Gly Ser 
                85                  90                  95      

Lys Leu Gly Arg Ala Ile Glu Tyr Ser Leu Lys Tyr Glu Glu Thr Phe 
            100                 105                 110         

Lys Thr Ile Leu Lys Asp Gly His Leu Val Leu Ser Asn Asn Leu Ala 
        115                 120                 125             

Glu Arg Ala Ile Lys Ser Leu Val Met Gly Arg Ser Lys Arg Val Gln 
    130                 135                 140                 

Trp Thr Leu Leu Ala 
145                 

<210>   2931
<211>   1317
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2931
atggaaaatc ctctgagaaa agtgtttgcc catctggaca actcagtctt tttgaagagg   60
aacaaaatat ggaagaagac tctgacttac ccagttgaaa gagaagaaat cacctataaa   120
cgtaagaaag ctaaagggaa acgtcaagct cttcttgccc aatttgattc agaagaagtt   180
catcatcaag tagaagagag catttgccct gattgtcagg gagatctaaa agagattgga   240
gcaacccttc aacgacaaga attagtcttt attcctgcgc aattaaaacg aatagatcat   300
atccaacacg cttataagtg ccaagcatgc agtgataaaa atccgagtga taaaatcgtg   360
aaagctccta ttcctaaagc ccctttggcg catagccttg gctcagcttc tattatcgct   420
cacaccatcc atcagaagtt taatctgaag gtacccaatt atcgccaaga agaagattgg   480
gctaagatgg gtttaccaat cacacgtaag gaaattgcta attggcatat caaggcgagt   540
caatactatt tggagcccct ttataatctt ttacgagaaa agttgttaga acaagctctt   600
cttcatgcgg atgaaacctc ttatcgggtt ctagagagtg atagtcagtt gccttactat   660
tggacttttt tgtctgggaa agctgagaat caagcaatca cgctgtacca ccatgatcag   720
cgtcggagtg gtttagtagt acaagaattc ctaggagatt attctggcta tgttcattgt   780
gacatgttgc ggcagtaact taggacttta gtcctctagt tctgcctatg cgatagcagt   840
ccaaggttta ggagtaaggc gacgctaagc ttggtaaact gcgaacagct agaagcttat   900
cgtcaactgg aagaagctgc acttgttgga tgttgggcgc atgtgagaag gaagtttttt   960
gaagtgcccc ccaagcaagc agataaatca tccttaggag ctaaaggttt agcttattgt   1020
gatcagttat tttccttgga aagagactgg gaggctttgc cagctgatga acgactacag   1080
aaacgtcaag aacatctcca gcccctaatg gaagacttct ttgcttggtg ccgccgtcag   1140
tcagttttag caggttcaaa actaggaagg gcaattgaat acagcctcaa gtatgaagaa   1200
acctttaaga ctattttgaa agacggacat ctggtccttt ccaataatct agctgaacgc   1260
gccattaaat cattggttat gggacggagt aaaagagtcc agtggactct tttagcc      1317

<210>   2932
<211>   146
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf3, degenerate

<400>   2932
Met Lys Ala Pro Ile Pro Lys Ala Pro Leu Ala His Ser Leu Gly Ser 
1               5                   10                  15      

Ala Ser Ile Ile Ala His Thr Ile His Gln Lys Phe Asn Leu Lys Val 
            20                  25                  30          

Pro Asn Tyr Arg Gln Glu Glu Asp Trp Ala Lys Met Gly Leu Pro Ile 
        35                  40                  45              

Thr Arg Lys Glu Ile Ala Asn Trp His Ile Lys Ala Ser Gln Tyr Tyr 
    50                  55                  60                  

Leu Glu Pro Leu Tyr Asn Leu Leu Arg Glu Lys Leu Leu Glu Gln Ala 
65                  70                  75                  80  

Leu Leu His Ala Asp Glu Thr Ser Tyr Arg Val Leu Glu Ser Asp Ser 
                85                  90                  95      

Gln Leu Pro Tyr Tyr Trp Thr Phe Leu Ser Gly Lys Ala Glu Asn Gln 
            100                 105                 110         

Ala Ile Thr Leu Tyr His His Asp Gln Arg Arg Ser Gly Leu Val Val 
        115                 120                 125             

Gln Glu Phe Leu Gly Asp Tyr Ser Gly Tyr Val His Cys Asp Met Leu 
    130                 135                 140                 

Arg Gln 
145     

<210>   2933
<211>   192
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2933
ttgaaaatca ttcaacaaca gagtgctaca attgatagtc tcaccaatga acttgccctt   60
cttcgtgaac aagtggctta tctaacgcaa aagctctatg gaaaatcctc tgagaaaagt   120
gtttgcccat ctggacaact cagtcttttt gaagaggaac aaaatatgga agaagactct   180
gacttaccca gt                                                       192

<210>   2934
<211>   64
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   2934
Met Lys Ile Ile Gln Gln Gln Ser Ala Thr Ile Asp Ser Leu Thr Asn 
1               5                   10                  15      

Glu Leu Ala Leu Leu Arg Glu Gln Val Ala Tyr Leu Thr Gln Lys Leu 
            20                  25                  30          

Tyr Gly Lys Ser Ser Glu Lys Ser Val Cys Pro Ser Gly Gln Leu Ser 
        35                  40                  45              


Leu Phe Glu Glu Glu Gln Asn Met Glu Glu Asp Ser Asp Leu Pro Ser 
    50                  55                  60                  


<210>   2935
<211>   348
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2935
atgacaattc atctatctag cctagggcag gtctatctcg tatgtgggaa aacggatatg   60
aggcaaggca ttgattcatt ggcttatctg gttaaaaccc actttgaatt agatcctttc   120
tccggtcaag tttttctctt ttgtggtgga cgtaaagacc gctttaaagc cctttactgg   180
gatggtcaag gattttggct actatataaa cgctttgaga acggaaaact gacttggccc   240
agtacagaaa aggatgtcaa agctctcaca cctgaacaag tagattggct tatgaagggc   300
ttttctatca ctccaaaaat aaatttatca gaaagtcgtg atttctat                348

<210>   2936
<211>   116
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903341 (4.E-67)

<400>   2936
Met Thr Ile His Leu Ser Ser Leu Gly Gln Val Tyr Leu Val Cys Gly 
1               5                   10                  15      

Lys Thr Asp Met Arg Gln Gly Ile Asp Ser Leu Ala Tyr Leu Val Lys 
            20                  25                  30          

Thr His Phe Glu Leu Asp Pro Phe Ser Gly Gln Val Phe Leu Phe Cys 
        35                  40                  45              

Gly Gly Arg Lys Asp Arg Phe Lys Ala Leu Tyr Trp Asp Gly Gln Gly 
    50                  55                  60                  

Phe Trp Leu Leu Tyr Lys Arg Phe Glu Asn Gly Lys Leu Thr Trp Pro 
65                  70                  75                  80  

Ser Thr Glu Lys Asp Val Lys Ala Leu Thr Pro Glu Gln Val Asp Trp 
                85                  90                  95      

Leu Met Lys Gly Phe Ser Ile Thr Pro Lys Ile Asn Leu Ser Glu Ser 
            100                 105                 110         

Arg Asp Phe Tyr 
        115     

<210>   2937
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2937
atggagttcc tcctgtatac tattagtaaa gtaaaactat tggaggatat tttaatgcca   60
caacctattg ttcctgtaga gattccacaa tctcgtcgtt ttgattctaa aaagagaaat   120
gatattctgc ttaaaattcg tattggcaag cttgaagtaa gtttttttca atctctcaat   180
ctcgaaatgg tagaacagct tttggataaa gtgttgctct atgacaattc atctatc      237

<210>   2938
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf1
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903342 (1.E-38)

<400>   2938
Met Glu Phe Leu Leu Tyr Thr Ile Ser Lys Val Lys Leu Leu Glu Asp 
1               5                   10                  15      

Ile Leu Met Pro Gln Pro Ile Val Pro Val Glu Ile Pro Gln Ser Arg 
            20                  25                  30          

Arg Phe Asp Ser Lys Lys Arg Asn Asp Ile Leu Leu Lys Ile Arg Ile 
        35                  40                  45              

Gly Lys Leu Glu Val Ser Phe Phe Gln Ser Leu Asn Leu Glu Met Val 
    50                  55                  60                  

Glu Gln Leu Leu Asp Lys Val Leu Leu Tyr Asp Asn Ser Ser Ile 
65                  70                  75                  

<210>   2939
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2939
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accttctaaa   180
attccttatc ttgaaacgac tggtatgcct actagaattc tccttagaaa gcgtcgattc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ctatcgtcaa gaagaatcac   300
caaatccctc gtatcatcaa ccaaaaaatt gctcaaaagt taattgaaaa gatttctatg   360
actgatattg cccatcagct ttccatctca acttcaactg ttattcgtaa gctcaatgac   420
tttcacttta aacatgattt ttcttgtctt cctgagatta tgtcttggga tgagtatgct   480
tttacaaagg gaaagatgag cttcattgcg caagatttta acaatctcaa tatcatcact   540
gttcttgagg gaagaacaca agctatcatt cgaaatcact ttcttaaata tgatagagcc   600
gtccgatgtc gcgtcaaaat tattactatg gatatgttta gtccttacta tgacttagct   660
agacaacttt tcccatgtgc taaaatcgtg ttggatcgct ttcacattgt acaacatctt   720
agccgtgcta tgagtcgtgt gcgtgttcaa atcatgaatc aattggatcg aaagtctcat   780
gaatacaagg ctatcaagcg ctactggaag ctcatacaac aggatagtcg taaactcagc   840
gataaacatt tttatcgccc tacttttcgt atgcatttaa ccaataaaga gattttaaac   900
aagcttttga gctattcaca agacttgaaa catcactatc agctctatca actcttgctg   960
tttcactttc agaataagga accggagaaa tttttcggac tcattgagga caatctaaag   1020
caggttcatc ctctttttca gactgtcttt aaaacctttc taaaggacaa agagaaaatc   1080
gtcaacgccc ttcaactaca ctattctaac gccaaattgg aagcgaccaa taatctcatc   1140
aaacttatca agcgcaatgc ctttggtttt cggaactttg aaaacttcaa aaaacggatt   1200
tttatcgctc tgaatatcaa aaaagaaagg acaaaatttg tcctttctcg agct         1254

<210>   2940
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903343 (0.E+01)

<400>   2940
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ser 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Lys 
    130                 135                 140                 

His Asp Phe Ser Cys Leu Pro Glu Ile Met Ser Trp Asp Glu Tyr Ala 
145                 150                 155                 160 

Phe Thr Lys Gly Lys Met Ser Phe Ile Ala Gln Asp Phe Asn Asn Leu 
                165                 170                 175     

Asn Ile Ile Thr Val Leu Glu Gly Arg Thr Gln Ala Ile Ile Arg Asn 
            180                 185                 190         

His Phe Leu Lys Tyr Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile 
        195                 200                 205             

Thr Met Asp Met Phe Ser Pro Tyr Tyr Asp Leu Ala Arg Gln Leu Phe 
    210                 215                 220                 

Pro Cys Ala Lys Ile Val Leu Asp Arg Phe His Ile Val Gln His Leu 
225                 230                 235                 240 

Ser Arg Ala Met Ser Arg Val Arg Val Gln Ile Met Asn Gln Leu Asp 
                245                 250                 255     

Arg Lys Ser His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile 
            260                 265                 270         

Gln Gln Asp Ser Arg Lys Leu Ser Asp Lys His Phe Tyr Arg Pro Thr 
        275                 280                 285             

Phe Arg Met His Leu Thr Asn Lys Glu Ile Leu Asn Lys Leu Leu Ser 
    290                 295                 300                 

Tyr Ser Gln Asp Leu Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu 
305                 310                 315                 320 

Phe His Phe Gln Asn Lys Glu Pro Glu Lys Phe Phe Gly Leu Ile Glu 
                325                 330                 335     

Asp Asn Leu Lys Gln Val His Pro Leu Phe Gln Thr Val Phe Lys Thr 
            340                 345                 350         

Phe Leu Lys Asp Lys Glu Lys Ile Val Asn Ala Leu Gln Leu His Tyr 
        355                 360                 365             

Ser Asn Ala Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys 
    370                 375                 380                 

Arg Asn Ala Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile 
385                 390                 395                 400 

Phe Ile Ala Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser 
                405                 410                 415     

Arg Ala 
        

<210>   2941
<211>   1560
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2941
atgagcaaca tttcaactga tttgcaagat gtagaaaaaa tcatcgtatt ggactatggt   60
agccagtaca accagctgat ttcacgccgt atccgtgaga ttggtgtttt ttcagaacta   120
aaaagccata aaatttcagc tgctgaagtt cgtgaagtca atcctgtagg aattattcta   180
tcaggtggtc caaattctgt atatgaagat ggttcatttg atattgaccc agaaatcttc   240
gaactcggaa ttccaatttt gggaatctgt tatggtatgc agttattgac ccataaactt   300
ggaggaaaag ttgttcctgc aggtgatgct ggaaatcgtg aatacggtca atcaacccta   360
actcacacac catcagcgct ttttgaatca acacctgatg aacagactgt tttgatgagc   420
catggtgatg cggttactga gattcctgct gactttgttc gtacaggtac atcagctgac   480
tgcccatacg cagccatcga aaacccagat aaacacattt acggtatcca attccaccca   540
gaagttcgtc attctgtata cggaaatgat atccttcgta actttgccct taacatttgt   600
aaggctaaag gtgactggtc aatggataat ttcattgaca tgcagatcaa aaaaattcgt   660
gaaaccgtcg gtgataaacg tgtccttctt ggtctatcag gtggtgttga ctcatctgtc   720
gttggggttc ttctccaaaa agcgattggc gatcaattga tctgtatctt cgtagaccac   780
ggtcttcttc gtaaaggcga agctgatcaa gttatggaca tgctcggtgg taagtttggt   840
ttgaatatcg tcaaagcaga cgctgctaaa cgtttccttg acaaacttgc tggcgtttct   900
gaccctgaac aaaaacgtaa aatcatcggt aacgagtttg tctatgtatt cgatgacgaa   960
gcaagcaagc tcaaagatgt gaaattcctt gctcaaggta ctttatatac agatgttatc   1020
gagtctggta cggatacagc tcaaactatc aagtcacacc acaacgtggg tggtcttcca   1080
gaagatatgc agtttgaatt gattgaacca ctcaatactc tttacaagga tgaagttcgt   1140
gctcttggta cagagcttgg tatgccagac catatcgtat ggcgccaacc attcccagga   1200
ccaggacttg ctatccgtgt catgggtgaa atcactgaag agaaacttga aaccgttcgt   1260
gaatcagacg ctattcttcg tgaagaaatc gctaaagctg gacttgaccg cgatatttgg   1320
caatacttca ctgttaacac aggcgttcgt tcagtcggtg ttatgggtga cggtcgtacg   1380
tatgactaca cgattgcaat ccgtgctatc acttctatcg atggtatgac tgctgatttt   1440
gccaaaattc catgggaagt acttcaaaaa atctcagtac gtatcgtaaa tgaagtggat   1500
catgttaacc gtatcgtcta cgatattaca agtaaaccac ctgcaacagt tgagtgggaa   1560

<210>   2942
<211>   520
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GMP synthase (guaA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903580 (8.E-38)

<400>   2942
Met Ser Asn Ile Ser Thr Asp Leu Gln Asp Val Glu Lys Ile Ile Val 
1               5                   10                  15      

Leu Asp Tyr Gly Ser Gln Tyr Asn Gln Leu Ile Ser Arg Arg Ile Arg 
            20                  25                  30          

Glu Ile Gly Val Phe Ser Glu Leu Lys Ser His Lys Ile Ser Ala Ala 
        35                  40                  45              

Glu Val Arg Glu Val Asn Pro Val Gly Ile Ile Leu Ser Gly Gly Pro 
    50                  55                  60                  

Asn Ser Val Tyr Glu Asp Gly Ser Phe Asp Ile Asp Pro Glu Ile Phe 
65                  70                  75                  80  

Glu Leu Gly Ile Pro Ile Leu Gly Ile Cys Tyr Gly Met Gln Leu Leu 
                85                  90                  95      

Thr His Lys Leu Gly Gly Lys Val Val Pro Ala Gly Asp Ala Gly Asn 
            100                 105                 110         

Arg Glu Tyr Gly Gln Ser Thr Leu Thr His Thr Pro Ser Ala Leu Phe 
        115                 120                 125             

Glu Ser Thr Pro Asp Glu Gln Thr Val Leu Met Ser His Gly Asp Ala 
    130                 135                 140                 

Val Thr Glu Ile Pro Ala Asp Phe Val Arg Thr Gly Thr Ser Ala Asp 
145                 150                 155                 160 

Cys Pro Tyr Ala Ala Ile Glu Asn Pro Asp Lys His Ile Tyr Gly Ile 
                165                 170                 175     

Gln Phe His Pro Glu Val Arg His Ser Val Tyr Gly Asn Asp Ile Leu 
            180                 185                 190         

Arg Asn Phe Ala Leu Asn Ile Cys Lys Ala Lys Gly Asp Trp Ser Met 
        195                 200                 205             

Asp Asn Phe Ile Asp Met Gln Ile Lys Lys Ile Arg Glu Thr Val Gly 
    210                 215                 220                 

Asp Lys Arg Val Leu Leu Gly Leu Ser Gly Gly Val Asp Ser Ser Val 
225                 230                 235                 240 

Val Gly Val Leu Leu Gln Lys Ala Ile Gly Asp Gln Leu Ile Cys Ile 
                245                 250                 255     

Phe Val Asp His Gly Leu Leu Arg Lys Gly Glu Ala Asp Gln Val Met 
            260                 265                 270         

Asp Met Leu Gly Gly Lys Phe Gly Leu Asn Ile Val Lys Ala Asp Ala 
        275                 280                 285             

Ala Lys Arg Phe Leu Asp Lys Leu Ala Gly Val Ser Asp Pro Glu Gln 
    290                 295                 300                 

Lys Arg Lys Ile Ile Gly Asn Glu Phe Val Tyr Val Phe Asp Asp Glu 
305                 310                 315                 320 

Ala Ser Lys Leu Lys Asp Val Lys Phe Leu Ala Gln Gly Thr Leu Tyr 
                325                 330                 335     

Thr Asp Val Ile Glu Ser Gly Thr Asp Thr Ala Gln Thr Ile Lys Ser 
            340                 345                 350         

His His Asn Val Gly Gly Leu Pro Glu Asp Met Gln Phe Glu Leu Ile 
        355                 360                 365             

Glu Pro Leu Asn Thr Leu Tyr Lys Asp Glu Val Arg Ala Leu Gly Thr 
    370                 375                 380                 

Glu Leu Gly Met Pro Asp His Ile Val Trp Arg Gln Pro Phe Pro Gly 
385                 390                 395                 400 

Pro Gly Leu Ala Ile Arg Val Met Gly Glu Ile Thr Glu Glu Lys Leu 
                405                 410                 415     

Glu Thr Val Arg Glu Ser Asp Ala Ile Leu Arg Glu Glu Ile Ala Lys 
            420                 425                 430         

Ala Gly Leu Asp Arg Asp Ile Trp Gln Tyr Phe Thr Val Asn Thr Gly 
        435                 440                 445             

Val Arg Ser Val Gly Val Met Gly Asp Gly Arg Thr Tyr Asp Tyr Thr 
    450                 455                 460                 

Ile Ala Ile Arg Ala Ile Thr Ser Ile Asp Gly Met Thr Ala Asp Phe 
465                 470                 475                 480 

Ala Lys Ile Pro Trp Glu Val Leu Gln Lys Ile Ser Val Arg Ile Val 
                485                 490                 495     

Asn Glu Val Asp His Val Asn Arg Ile Val Tyr Asp Ile Thr Ser Lys 
            500                 505                 510         

Pro Pro Ala Thr Val Glu Trp Glu 
        515                 520 

<210>   2943
<211>   705
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2943
gtgaaaaata tgctacctgc ttatataaaa atccatgatc agataaaaaa ggatattgac   60
gagtaccgtt gggctattgg tgagaggctt cccagtgaaa gagatttagc tgagcagttt   120
gcggtcagtc gcatgaccct ccgccaagcc gtatctctat tagtcgaaga aggcgtctta   180
gagcgccgtg taggaagcgg cacctttgtt tccagtactc gagtacaaga aaagatgcga   240
gggacaacca gttttactga aattgtcaaa tcccaaggta aagttccctc tagccagctc   300
atttcctaca aaaaaaccat tcccaatgag caagaagttg ccaagctagg aatttttcca   360
acggacaata ttatccgaat ggagcgggtc cgctatgccg accaagttcc cctagtttat   420
gaagttgctt ctattcctga aaaattcatt aaggacttta aaaaagaaga aatcaccagt   480
catttcttcc aaaccttgca aaaacatggc tatcgtatcg gcaaatctca acagaccatc   540
tatgctcgcc ttgctaaaga aaagattgcc cactatttgg aagttgaaaa aggacatgct   600
attcttggat tgacccaggt ttcctaccta gaagatggta ctgcttttga atacgtaaaa   660
agtcaatatg taggcgaacg ctttgaattt tatcttgaaa ataat                   705

<210>   2944
<211>   235
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, GntR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903344 (e-131)

<400>   2944
Met Lys Asn Met Leu Pro Ala Tyr Ile Lys Ile His Asp Gln Ile Lys 
1               5                   10                  15      

Lys Asp Ile Asp Glu Tyr Arg Trp Ala Ile Gly Glu Arg Leu Pro Ser 
            20                  25                  30          

Glu Arg Asp Leu Ala Glu Gln Phe Ala Val Ser Arg Met Thr Leu Arg 
        35                  40                  45              

Gln Ala Val Ser Leu Leu Val Glu Glu Gly Val Leu Glu Arg Arg Val 
    50                  55                  60                  

Gly Ser Gly Thr Phe Val Ser Ser Thr Arg Val Gln Glu Lys Met Arg 
65                  70                  75                  80  

Gly Thr Thr Ser Phe Thr Glu Ile Val Lys Ser Gln Gly Lys Val Pro 
                85                  90                  95      

Ser Ser Gln Leu Ile Ser Tyr Lys Lys Thr Ile Pro Asn Glu Gln Glu 
            100                 105                 110         

Val Ala Lys Leu Gly Ile Phe Pro Thr Asp Asn Ile Ile Arg Met Glu 
        115                 120                 125             

Arg Val Arg Tyr Ala Asp Gln Val Pro Leu Val Tyr Glu Val Ala Ser 
    130                 135                 140                 

Ile Pro Glu Lys Phe Ile Lys Asp Phe Lys Lys Glu Glu Ile Thr Ser 
145                 150                 155                 160 

His Phe Phe Gln Thr Leu Gln Lys His Gly Tyr Arg Ile Gly Lys Ser 
                165                 170                 175     

Gln Gln Thr Ile Tyr Ala Arg Leu Ala Lys Glu Lys Ile Ala His Tyr 
            180                 185                 190         

Leu Glu Val Glu Lys Gly His Ala Ile Leu Gly Leu Thr Gln Val Ser 
        195                 200                 205             

Tyr Leu Glu Asp Gly Thr Ala Phe Glu Tyr Val Lys Ser Gln Tyr Val 
    210                 215                 220                 

Gly Glu Arg Phe Glu Phe Tyr Leu Glu Asn Asn 
225                 230                 235 

<210>   2945
<211>   894
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2945
atgtcaaata gtttaaaagg gactttacta acagttgtgg ctggtattgc ttgggggttg   60
tcaggaacga gtggccaata cctaatggca cacggaattt cggctctggt cttgactaac   120
ttgcgtcttt taatcgctgg tggaattctc atgctcttgg cttatgctac tgcaaaggat   180
aaaatactgg tctttttaaa ggatagaaag agtttgctgt ctcttcttat ttttgctctg   240
attggtcttt ttctcaacca attcgcctat ctgtctgcta ttcaggagac caatgcggga   300
acagcgacgg tgcttcagta tgtttgtcct gtcggaattt taatttatag ctgtatcaag   360
gatagggtgg caccgacact gggagagata gtttccatca tattcgccat cggaggaacc   420
ttcctgatcg caacacatgg gcagttggac cagttatcca tgacacctgc tggtctgttc   480
tggggtctct tttctgcctt gacttatgct ctgtatatca ttttacccat agccttgatt   540
aaaaagtggg ggagcagctt ggtcattggt gtgggaatgg tcatagcagg tttggtcgcc   600
cttcctttta caggggttct acaggccgat atcccgacta gtcttgattt tctccttgcg   660
tttgcaggca ttatccttat cgggactgtc tttgcctata cagctttcct taaaggagcc   720
agtctgatag gaccggtcaa gtcaagcttg ttggcttcaa ttgagccaat atcggcgatt   780
ttctttgcct tcttaataat gaatgaacaa ttttatccca ttgattttct tggtatggca   840
atgatattgt ttgctgtaac tttgatttct ttgaaagatt tattcttaga aaaa         894

<210>   2946
<211>   298
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903345 (e-163)

<400>   2946
Met Ser Asn Ser Leu Lys Gly Thr Leu Leu Thr Val Val Ala Gly Ile 
1               5                   10                  15      

Ala Trp Gly Leu Ser Gly Thr Ser Gly Gln Tyr Leu Met Ala His Gly 
            20                  25                  30          

Ile Ser Ala Leu Val Leu Thr Asn Leu Arg Leu Leu Ile Ala Gly Gly 
        35                  40                  45              

Ile Leu Met Leu Leu Ala Tyr Ala Thr Ala Lys Asp Lys Ile Leu Val 
    50                  55                  60                  

Phe Leu Lys Asp Arg Lys Ser Leu Leu Ser Leu Leu Ile Phe Ala Leu 
65                  70                  75                  80  

Ile Gly Leu Phe Leu Asn Gln Phe Ala Tyr Leu Ser Ala Ile Gln Glu 
                85                  90                  95      

Thr Asn Ala Gly Thr Ala Thr Val Leu Gln Tyr Val Cys Pro Val Gly 
            100                 105                 110         

Ile Leu Ile Tyr Ser Cys Ile Lys Asp Arg Val Ala Pro Thr Leu Gly 
        115                 120                 125             

Glu Ile Val Ser Ile Ile Phe Ala Ile Gly Gly Thr Phe Leu Ile Ala 
    130                 135                 140                 

Thr His Gly Gln Leu Asp Gln Leu Ser Met Thr Pro Ala Gly Leu Phe 
145                 150                 155                 160 

Trp Gly Leu Phe Ser Ala Leu Thr Tyr Ala Leu Tyr Ile Ile Leu Pro 
                165                 170                 175     

Ile Ala Leu Ile Lys Lys Trp Gly Ser Ser Leu Val Ile Gly Val Gly 
            180                 185                 190         

Met Val Ile Ala Gly Leu Val Ala Leu Pro Phe Thr Gly Val Leu Gln 
        195                 200                 205             

Ala Asp Ile Pro Thr Ser Leu Asp Phe Leu Leu Ala Phe Ala Gly Ile 
    210                 215                 220                 

Ile Leu Ile Gly Thr Val Phe Ala Tyr Thr Ala Phe Leu Lys Gly Ala 
225                 230                 235                 240 

Ser Leu Ile Gly Pro Val Lys Ser Ser Leu Leu Ala Ser Ile Glu Pro 
                245                 250                 255     

Ile Ser Ala Ile Phe Phe Ala Phe Leu Ile Met Asn Glu Gln Phe Tyr 
            260                 265                 270         

Pro Ile Asp Phe Leu Gly Met Ala Met Ile Leu Phe Ala Val Thr Leu 
        275                 280                 285             

Ile Ser Leu Lys Asp Leu Phe Leu Glu Lys 
    290                 295             

<210>   2947
<211>   933
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2947
atgaagtgga ccaagattat taaaaaaata gaagaacaaa tcgaggcagg gatttatccc   60

ggagcctctt ttgcgtattt taaggacaat caatggacag agttctattt aggccagagt   120
gacccagagc atggcttgca gactgaggca ggactagttt atgacctagc tagtgtcagc   180
aaggttgttg gggttggcac agtttgtacc ttcttgtggg aaataggtca attagatatt   240
gatagactgg taatagattt tttacctgag agtgattatc cagacatcac tattcgccag   300
ctcttgactc atgcaacaga ccttgatcct tttattccta atcgtgatct tttaacagcc   360
cctgaattaa aggaagcgat gtttcatctc aacagacgaa gtcagccagc ctttctttat   420
tcggatgtcc attttttgct gttgggcttt attttggaaa gaatttttaa tcaagatttg   480
gatgtgattt taaaggatca agtctggaaa ccttggggaa tgacggaaac taagtttggg   540
ccagttgagc ttgctgttcc aacagttaga ggtgtagagg caggcatagt gcatgatccc   600
aaggctcgtc tcctgggtag acatgctggg agtgctggtt tattttcgac tataaaggat   660
ttacaaatct ttttagaaca ctatttagca gatgattttg caagagactt aaatcaaaat   720
ttttctcctt tggatgacaa ggaacgttct ttagcatgga atttggaagg agattggcta   780
gaccatacgg gctatacagg tacctttatc atgtggaatc gtcagaagca agaagccact   840
attttcctat cgaatcgtac ctatgaaaag gacgagagag ctcaatggat attagaccgc   900
aatcaagtga tgaacttgat tcgcaaagaa gag                                933

<210>   2948
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903346 (0.E+01)

<400>   2948
Met Lys Trp Thr Lys Ile Ile Lys Lys Ile Glu Glu Gln Ile Glu Ala 
1               5                   10                  15      

Gly Ile Tyr Pro Gly Ala Ser Phe Ala Tyr Phe Lys Asp Asn Gln Trp 
            20                  25                  30          

Thr Glu Phe Tyr Leu Gly Gln Ser Asp Pro Glu His Gly Leu Gln Thr 
        35                  40                  45              

Glu Ala Gly Leu Val Tyr Asp Leu Ala Ser Val Ser Lys Val Val Gly 
    50                  55                  60                  

Val Gly Thr Val Cys Thr Phe Leu Trp Glu Ile Gly Gln Leu Asp Ile 
65                  70                  75                  80  

Asp Arg Leu Val Ile Asp Phe Leu Pro Glu Ser Asp Tyr Pro Asp Ile 
                85                  90                  95      

Thr Ile Arg Gln Leu Leu Thr His Ala Thr Asp Leu Asp Pro Phe Ile 
            100                 105                 110         

Pro Asn Arg Asp Leu Leu Thr Ala Pro Glu Leu Lys Glu Ala Met Phe 
        115                 120                 125             

His Leu Asn Arg Arg Ser Gln Pro Ala Phe Leu Tyr Ser Asp Val His 
    130                 135                 140                 

Phe Leu Leu Leu Gly Phe Ile Leu Glu Arg Ile Phe Asn Gln Asp Leu 
145                 150                 155                 160 

Asp Val Ile Leu Lys Asp Gln Val Trp Lys Pro Trp Gly Met Thr Glu 
                165                 170                 175     

Thr Lys Phe Gly Pro Val Glu Leu Ala Val Pro Thr Val Arg Gly Val 
            180                 185                 190         

Glu Ala Gly Ile Val His Asp Pro Lys Ala Arg Leu Leu Gly Arg His 
        195                 200                 205             

Ala Gly Ser Ala Gly Leu Phe Ser Thr Ile Lys Asp Leu Gln Ile Phe 
    210                 215                 220                 

Leu Glu His Tyr Leu Ala Asp Asp Phe Ala Arg Asp Leu Asn Gln Asn 
225                 230                 235                 240 

Phe Ser Pro Leu Asp Asp Lys Glu Arg Ser Leu Ala Trp Asn Leu Glu 
                245                 250                 255     

Gly Asp Trp Leu Asp His Thr Gly Tyr Thr Gly Thr Phe Ile Met Trp 
            260                 265                 270         

Asn Arg Gln Lys Gln Glu Ala Thr Ile Phe Leu Ser Asn Arg Thr Tyr 
        275                 280                 285             

Glu Lys Asp Glu Arg Ala Gln Trp Ile Leu Asp Arg Asn Gln Val Met 
    290                 295                 300                 

Asn Leu Ile Arg Lys Glu Glu 
305                 310     

<210>   2949
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2949
gtgacggagg aatttatgaa tgtaaatcag attgtacgga ttattcctac tttaaaagct   60
aataatagaa aattaaatga aacattttat attgaaaccc ttggaatgaa ggccttgtta   120
gaagaatcgg cctttctgtc actaggtgac caaacgggtc ttgaaaagct ggttttagaa   180
gaagctccca gtatgcgtac tcgtaaggta gagggaagaa aaaaactagc tagattgatt   240
gtcaaggtgg aaaatccctt agaaattgaa ggaatcttat ctaaaacaga ttcgattcat   300
cgattatata aaggtcaaaa tggctacgct tttgaaattt tctcaccaga agatgatttg   360
attttgattc atgcggaaga tgacatagca agtctagtag aagtaggaga aaagcctgaa   420
tttcaaacag atttggcatc aatttcttta agtaaatttg agatttctat ggaattacat   480
ctcccaactg atatcgaaag tttcttggaa tcatctgaaa ttggggcatc ccttgatttt   540
attccagctc aggggcagga tttgactgtg gacaatacgg ttacctggga cttatctatg   600
ctcaagttct tggtcaatga attagacata gcaagtcttc gccagaagtt tgagtctact   660
gaatatttta ttcctaagtc tgaaaaattc ttccttggta aagatagaaa taatgttgaa   720
ttgtggtttg aagaagta                                                 738

<210>   2950
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cppA protein (cppA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903347 (e-134)

<400>   2950
Met Thr Glu Glu Phe Met Asn Val Asn Gln Ile Val Arg Ile Ile Pro 
1               5                   10                  15      

Thr Leu Lys Ala Asn Asn Arg Lys Leu Asn Glu Thr Phe Tyr Ile Glu 
            20                  25                  30          

Thr Leu Gly Met Lys Ala Leu Leu Glu Glu Ser Ala Phe Leu Ser Leu 
        35                  40                  45              

Gly Asp Gln Thr Gly Leu Glu Lys Leu Val Leu Glu Glu Ala Pro Ser 
    50                  55                  60                  

Met Arg Thr Arg Lys Val Glu Gly Arg Lys Lys Leu Ala Arg Leu Ile 
65                  70                  75                  80  

Val Lys Val Glu Asn Pro Leu Glu Ile Glu Gly Ile Leu Ser Lys Thr 
                85                  90                  95      

Asp Ser Ile His Arg Leu Tyr Lys Gly Gln Asn Gly Tyr Ala Phe Glu 
            100                 105                 110         

Ile Phe Ser Pro Glu Asp Asp Leu Ile Leu Ile His Ala Glu Asp Asp 
        115                 120                 125             

Ile Ala Ser Leu Val Glu Val Gly Glu Lys Pro Glu Phe Gln Thr Asp 
    130                 135                 140                 

Leu Ala Ser Ile Ser Leu Ser Lys Phe Glu Ile Ser Met Glu Leu His 
145                 150                 155                 160 

Leu Pro Thr Asp Ile Glu Ser Phe Leu Glu Ser Ser Glu Ile Gly Ala 
                165                 170                 175     

Ser Leu Asp Phe Ile Pro Ala Gln Gly Gln Asp Leu Thr Val Asp Asn 
            180                 185                 190         

Thr Val Thr Trp Asp Leu Ser Met Leu Lys Phe Leu Val Asn Glu Leu 
        195                 200                 205             

Asp Ile Ala Ser Leu Arg Gln Lys Phe Glu Ser Thr Glu Tyr Phe Ile 
    210                 215                 220                 

Pro Lys Ser Glu Lys Phe Phe Leu Gly Lys Asp Arg Asn Asn Val Glu 
225                 230                 235                 240 

Leu Trp Phe Glu Glu Val 
                245     

<210>   2951
<211>   633
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2951
gtggcagtac agttattaga aaattggctc ctaaaggaac aagaaaaaat tcaaactaag   60
tatcgtcacc taaatcacat ttctgttgta gaaccaaaca ttctttttat tggggattcc   120
attgtcgagt attatcctct acaggagcta tttgggactt caaagacgat tgtcaatcga   180
ggaattcgtg gctatcagac aggactgtta ctagagaacc ttgatgctca tctatatggt   240
ggagcagtag ataaaatttt tcttctgatt gggacaaatg atatcggaaa ggatgttcct   300
gtgaatgagg ctctcaataa tctcgaagct atcattcaat ccgttgctcg cgattatcca   360
ttgacagaga ttaaattgct ttccattttg cctgtcaatg agagagagga gtaccagcag   420
gcagtctata tccgctcgaa tgaaaaaatt cagaactgga atcaagccta tcaagagctt   480
gcatctgcct atatgcaggt ggaatttgtg ccagtatttg attgtttgac agaccaagca   540
ggccaactca aaaaagaata tacaactgat ggactgcacc tcagtattgc tggttatcag   600
gctttgtcaa aatccttgaa agactatctt tac                                633

<210>   2952
<211>   211
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   platelet activating factor, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903348 (e-119)

<400>   2952
Met Ala Val Gln Leu Leu Glu Asn Trp Leu Leu Lys Glu Gln Glu Lys 
1               5                   10                  15      

Ile Gln Thr Lys Tyr Arg His Leu Asn His Ile Ser Val Val Glu Pro 
            20                  25                  30          

Asn Ile Leu Phe Ile Gly Asp Ser Ile Val Glu Tyr Tyr Pro Leu Gln 
        35                  40                  45              

Glu Leu Phe Gly Thr Ser Lys Thr Ile Val Asn Arg Gly Ile Arg Gly 
    50                  55                  60                  

Tyr Gln Thr Gly Leu Leu Leu Glu Asn Leu Asp Ala His Leu Tyr Gly 
65                  70                  75                  80  

Gly Ala Val Asp Lys Ile Phe Leu Leu Ile Gly Thr Asn Asp Ile Gly 
                85                  90                  95      

Lys Asp Val Pro Val Asn Glu Ala Leu Asn Asn Leu Glu Ala Ile Ile 
            100                 105                 110         

Gln Ser Val Ala Arg Asp Tyr Pro Leu Thr Glu Ile Lys Leu Leu Ser 
        115                 120                 125             

Ile Leu Pro Val Asn Glu Arg Glu Glu Tyr Gln Gln Ala Val Tyr Ile 
    130                 135                 140                 

Arg Ser Asn Glu Lys Ile Gln Asn Trp Asn Gln Ala Tyr Gln Glu Leu 
145                 150                 155                 160 

Ala Ser Ala Tyr Met Gln Val Glu Phe Val Pro Val Phe Asp Cys Leu 
                165                 170                 175     

Thr Asp Gln Ala Gly Gln Leu Lys Lys Glu Tyr Thr Thr Asp Gly Leu 
            180                 185                 190         

His Leu Ser Ile Ala Gly Tyr Gln Ala Leu Ser Lys Ser Leu Lys Asp 
        195                 200                 205             

Tyr Leu Tyr 
    210     

<210>   2953
<211>   825
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2953
atgatgatta aggtaattgc gacagatatg gatgggacct tgctggatgc tagaggtcag   60
cttgatctcc cacgattgga aaagatttta gatcagttgg atcaaagggg cattcgtttt   120
gtcattgcga cgggcaatga aattcaccgc atgagacaac tactgagtcc cttggtggat   180
cgagtggttc tggttgttgc taatggcgct cgtatttttg aaaacaatga attgattcag   240
gctcagacat gggatgacgc cattgtcaac aaggctttga ctcatttcaa gggtcgagcg   300
tgtcaggacc agtttgttgt aacggggatg aagggtgatt ttgtcaagga aggtacgatt   360
tttacagatc ttgaaagttt tatgactcca gaaatgattg aaaaattcta ccaacggatg   420
caatttgtgg atgaattaac atctgacctc tttggtggtg tgctcaagat gagcatggtt   480
gttggtgagg aacgtttgag ttcggttttg gaagaaatca atgctctctt tgatggccgt   540
gtccgagctg tatccagtgg ctatggttgc attgatatcc tccaagctgg gattcataaa   600
gcatggggct tggaggaatt actcaagcgc tgggacttga aatcccaaga aatcatggct   660
tttggtgata gtgaaaatga tgttgaaatg cttgaaatgg ctggaattgc ctatgcgatg   720
gaaaatgctg atgagaaagc caaagctgtg gcgactgctc tagcaccagc caacagccaa   780
ggaggagttt atcaagtctt ggaaaactgg ttagaaaaag gagaa                   825

<210>   2954
<211>   275
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Cof family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903349 (e-155)

<400>   2954
Met Met Ile Lys Val Ile Ala Thr Asp Met Asp Gly Thr Leu Leu Asp 
1               5                   10                  15      

Ala Arg Gly Gln Leu Asp Leu Pro Arg Leu Glu Lys Ile Leu Asp Gln 
            20                  25                  30          

Leu Asp Gln Arg Gly Ile Arg Phe Val Ile Ala Thr Gly Asn Glu Ile 
        35                  40                  45              

His Arg Met Arg Gln Leu Leu Ser Pro Leu Val Asp Arg Val Val Leu 
    50                  55                  60                  

Val Val Ala Asn Gly Ala Arg Ile Phe Glu Asn Asn Glu Leu Ile Gln 
65                  70                  75                  80  

Ala Gln Thr Trp Asp Asp Ala Ile Val Asn Lys Ala Leu Thr His Phe 
                85                  90                  95      

Lys Gly Arg Ala Cys Gln Asp Gln Phe Val Val Thr Gly Met Lys Gly 
            100                 105                 110         

Asp Phe Val Lys Glu Gly Thr Ile Phe Thr Asp Leu Glu Ser Phe Met 
        115                 120                 125             

Thr Pro Glu Met Ile Glu Lys Phe Tyr Gln Arg Met Gln Phe Val Asp 
    130                 135                 140                 

Glu Leu Thr Ser Asp Leu Phe Gly Gly Val Leu Lys Met Ser Met Val 
145                 150                 155                 160 

Val Gly Glu Glu Arg Leu Ser Ser Val Leu Glu Glu Ile Asn Ala Leu 
                165                 170                 175     

Phe Asp Gly Arg Val Arg Ala Val Ser Ser Gly Tyr Gly Cys Ile Asp 
            180                 185                 190         

Ile Leu Gln Ala Gly Ile His Lys Ala Trp Gly Leu Glu Glu Leu Leu 
        195                 200                 205             

Lys Arg Trp Asp Leu Lys Ser Gln Glu Ile Met Ala Phe Gly Asp Ser 
    210                 215                 220                 

Glu Asn Asp Val Glu Met Leu Glu Met Ala Gly Ile Ala Tyr Ala Met 
225                 230                 235                 240 

Glu Asn Ala Asp Glu Lys Ala Lys Ala Val Ala Thr Ala Leu Ala Pro 
                245                 250                 255     

Ala Asn Ser Gln Gly Gly Val Tyr Gln Val Leu Glu Asn Trp Leu Glu 
            260                 265                 270         

Lys Gly Glu 
        275 

<210>   2955
<211>   297
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2955
atgggagatg aagagaatgc taagtggact gaacgtggtg ttctcatgga tgtcaccatc   60
aagaagaagg atggaaaaac aactatcgga acagctaaag ctcatcctac ttgggtcaat   120
cgaacaccaa agggaacctt ttcaccagaa ggatatccct tgtatcatta ccaaacttat   180
attttggaag attttataga ggatggcagt catcgtgacc agttagatga agcgactaag   240
gaacgaattg atacagccta taaagaaatg aatgaacatg tgggattgaa gtggtat      297

<210>   2956
<211>   99
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903350 (8.E-58)

<400>   2956
Met Gly Asp Glu Glu Asn Ala Lys Trp Thr Glu Arg Gly Val Leu Met 
1               5                   10                  15      

Asp Val Thr Ile Lys Lys Lys Asp Gly Lys Thr Thr Ile Gly Thr Ala 
            20                  25                  30          

Lys Ala His Pro Thr Trp Val Asn Arg Thr Pro Lys Gly Thr Phe Ser 
        35                  40                  45              

Pro Glu Gly Tyr Pro Leu Tyr His Tyr Gln Thr Tyr Ile Leu Glu Asp 
    50                  55                  60                  

Phe Ile Glu Asp Gly Ser His Arg Asp Gln Leu Asp Glu Ala Thr Lys 
65                  70                  75                  80  

Glu Arg Ile Asp Thr Ala Tyr Lys Glu Met Asn Glu His Val Gly Leu 
                85                  90                  95      

Lys Trp Tyr 
            

<210>   2957
<211>   510
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2957
atggatgcta ttaaggaggc aggttatcat gtgctggatt tagctcataa tcatattttg   60
gattcgcaaa ttgagggagt tatttcaacg gccgatatta ttgagaaagc tggaatcact   120
ccaatcggag tttatacgca cgaaccacgt gatcaggctc cgctggtcat taaggaagtg   180
aatggtatca aggttgcatt gttagcctat tcctatggtt tcaatggaat tgagcagtat   240
atttctcagg aagactataa tcgttatctt tcagatttaa acgaagataa gatgaaggtt   300
gaaattgaac gggcagagaa ggaagcagat atcaccatta tcatgcttca gatgggtgtt   360
gagtatcgat tggaaccaac tgaagaacaa aaagctcttt atcacaagat gatcgatttg   420
ggagcggata ttatctttgg agggcatcct cacgttgttg aaccatctga aacggttgaa   480
aaagatggag ataagaaact cattatctat                                    510

<210>   2958
<211>   170
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capA-related protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903351 (2.E-95)

<400>   2958
Met Asp Ala Ile Lys Glu Ala Gly Tyr His Val Leu Asp Leu Ala His 
1               5                   10                  15      

Asn His Ile Leu Asp Ser Gln Ile Glu Gly Val Ile Ser Thr Ala Asp 
            20                  25                  30          

Ile Ile Glu Lys Ala Gly Ile Thr Pro Ile Gly Val Tyr Thr His Glu 
        35                  40                  45              

Pro Arg Asp Gln Ala Pro Leu Val Ile Lys Glu Val Asn Gly Ile Lys 
    50                  55                  60                  

Val Ala Leu Leu Ala Tyr Ser Tyr Gly Phe Asn Gly Ile Glu Gln Tyr 
65                  70                  75                  80  

Ile Ser Gln Glu Asp Tyr Asn Arg Tyr Leu Ser Asp Leu Asn Glu Asp 
                85                  90                  95      

Lys Met Lys Val Glu Ile Glu Arg Ala Glu Lys Glu Ala Asp Ile Thr 
            100                 105                 110         

Ile Ile Met Leu Gln Met Gly Val Glu Tyr Arg Leu Glu Pro Thr Glu 
        115                 120                 125             

Glu Gln Lys Ala Leu Tyr His Lys Met Ile Asp Leu Gly Ala Asp Ile 
    130                 135                 140                 

Ile Phe Gly Gly His Pro His Val Val Glu Pro Ser Glu Thr Val Glu 
145                 150                 155                 160 

Lys Asp Gly Asp Lys Lys Leu Ile Ile Tyr 
                165                 170 

<210>   2959
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2959
atggcccacg gggatttgct ctaccacgat ggacttttct tttcagctaa aaaagaagac   60
ggtacctatg actttcatga aaattttgag tatgtgactc cttggctcaa gcaaggggac   120

<210>   2960
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2960
Met Ala His Gly Asp Leu Leu Tyr His Asp Gly Leu Phe Phe Ser Ala 
1               5                   10                  15      

Lys Lys Glu Asp Gly Thr Tyr Asp Phe His Glu Asn Phe Glu Tyr Val 
            20                  25                  30          

Thr Pro Trp Leu Lys Gln Gly Asp 
        35                  40  

<210>   2961
<211>   189
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2961
gtgaaagaaa tacttatctg tgatataata aaaagaaaag gcttgcataa gaaagtaggg   60
agaacgaaga tacaaagaag acaaaatcga aatcagggtg gtttagcttt tcgttttatg   120
aagggcttgg taaacttttt aggagttatc gcaagtggag caataaggga tttgtggcga   180
tactcttgc                                                           189

<210>   2962
<211>   63
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   2962
Met Lys Glu Ile Leu Ile Cys Asp Ile Ile Lys Arg Lys Gly Leu His 
1               5                   10                  15      

Lys Lys Val Gly Arg Thr Lys Ile Gln Arg Arg Gln Asn Arg Asn Gln 
            20                  25                  30          

Gly Gly Leu Ala Phe Arg Phe Met Lys Gly Leu Val Asn Phe Leu Gly 
        35                  40                  45              

Val Ile Ala Ser Gly Ala Ile Arg Asp Leu Trp Arg Tyr Ser Cys 
    50                  55                  60              

<210>   2963
<211>   609
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2963
atgtctgcaa tagaacgtat tacaaaagct gctcacttaa ttgatatgaa cgatattatc   60
cgtgaaggga atcctactct acgcgcgatt gctgaggaag tcactttccc cctatctgac   120
caggaaatca tcctaggcga aaagatgatg caattcctta aacattccca agatcctgtc   180
atggctgaaa aaatgggact ccgcggtggt gttggactgg ctgctcccca gttagatatc   240
tcaaaacgca ttatcgctgt tttggtacct aatattgttg aagaaggcga aactccacag   300
gaagcctacg atttggaagc cattatgtac aatccaaaaa tcgtctctca ctctgttcaa   360
gatgctgctc ttggcgaagg agaaggttgc ctgtctgttg accgtaacgt gcctggctat   420
gttgttcgcc atgcccgcgt tactgttgac tactttgaca aagatggaga aaaacaccgt   480
atcaaactca aaggctacaa ctccattgtt gttcagcatg aaattgacca cattaacggt   540
atcatgtttt acgatcgcat caatgaaaaa gacccatttg cagttaaaga tggtttactg   600
attcttgaa                                                           609

<210>   2964
<211>   203
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   polypeptide deformylase (def)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903353 (e-113)

<400>   2964
Met Ser Ala Ile Glu Arg Ile Thr Lys Ala Ala His Leu Ile Asp Met 
1               5                   10                  15      

Asn Asp Ile Ile Arg Glu Gly Asn Pro Thr Leu Arg Ala Ile Ala Glu 
            20                  25                  30          

Glu Val Thr Phe Pro Leu Ser Asp Gln Glu Ile Ile Leu Gly Glu Lys 
        35                  40                  45              

Met Met Gln Phe Leu Lys His Ser Gln Asp Pro Val Met Ala Glu Lys 
    50                  55                  60                  

Met Gly Leu Arg Gly Gly Val Gly Leu Ala Ala Pro Gln Leu Asp Ile 
65                  70                  75                  80  

Ser Lys Arg Ile Ile Ala Val Leu Val Pro Asn Ile Val Glu Glu Gly 
                85                  90                  95      

Glu Thr Pro Gln Glu Ala Tyr Asp Leu Glu Ala Ile Met Tyr Asn Pro 
            100                 105                 110         

Lys Ile Val Ser His Ser Val Gln Asp Ala Ala Leu Gly Glu Gly Glu 
        115                 120                 125             

Gly Cys Leu Ser Val Asp Arg Asn Val Pro Gly Tyr Val Val Arg His 
    130                 135                 140                 

Ala Arg Val Thr Val Asp Tyr Phe Asp Lys Asp Gly Glu Lys His Arg 
145                 150                 155                 160 

Ile Lys Leu Lys Gly Tyr Asn Ser Ile Val Val Gln His Glu Ile Asp 
                165                 170                 175     

His Ile Asn Gly Ile Met Phe Tyr Asp Arg Ile Asn Glu Lys Asp Pro 
            180                 185                 190         

Phe Ala Val Lys Asp Gly Leu Leu Ile Leu Glu 
        195                 200             

<210>   2965
<211>   760
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2965
ttgcaagacg gggttttgtg ttataataga ggcatgaaaa caaatgatat tgtctatggt   60
gtccacgccg ttaccgaagc cctccttgca aatacaggaa acaaactcta cctccaagaa   120
gatctccgag gtaagaatgt tgagaaagtc aaggaactag ctacagaaaa gaaggtgtcc   180
atttcttgga catcaaaaaa atctctctct gagattactg aaggtgctgt tcatcaaggt   240
tttgttctac gagtgtctga atttgcctat agcgagctag attacatcct tgcaaaaaca   300
cgccaagaag aaaatccact tctattgatt ctagatggtc taaccgatcc ccataatctg   360
ggttctatct tgcgaacagc cgatgcgacc aatgtttcag gtgtcatcat tcccaagcac   420
cgtactgtcg gagtaactcc tgtcgttgcc aaaacagcca caggtgctat tgaacacgtt   480
ccaattgccc gagtgaccaa cctcagtcaa accttaggat aaacttaagg atgaaggttt   540
ctggaccttt ggaacggata tgaacggtac tccttgccac aagtggaata caaaagggaa   600
aatcgccctc atcattggaa atgaaggaaa aggtatctct agcaacatca aaaaacaggt   660
cgatgaaatg attaccattc cgatgaatgg acatgttcaa agccttaatg ccagtgttgc   720
tgcggccatt ctcatgtacg aagttttccg aaatagacta                         760


<210>   2966
<400>   2966
000

<210>   2967
<211>   909
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2967
atgtacgata ctattattat cggtgctgga cctgcaggga tgactgcggc cttgtatgct   60
gctcgaagca atctaaaagt agctttgatt gaaggtggtc tgccaggtgg tcagatgaat   120
aatacatctg atatcgaaaa ttacccagga tacgctaata ttagtggacc tgaattggct   180
gaaaagatgt ttgaaccact tgaaaatctt ggtgttgagc acatttatgg ttatgttgaa   240
aatgtcgaag accatggtga ttttaagaaa gtgatgactg atgaccaaac atatgaaaca   300
cgtacagtta tcgtagcaac tggttctaaa caccgtcctt tgggagtgcc tggagaagaa   360
gaactgaaca gtcgtggtgt ttcttactgt gctgtgtgtg atggtgcttt cttccgtgac   420
caagatttat tggtagttgg tggtggagat tcagctgttg aagaagccct cttcttgact   480
cgttttgcta agactgttac cattgttcac cgtcgtgacc aacttcgtgc ccaaaaggtt   540
ttacaagatc gcgcctttgc gaatgaaaaa atcagcttta tctgggattc tgtagtaagg   600
gaaatcaagg gtgaaaaccg agtagaatca gtcgtatttg aaaatgtgaa aacaggtcaa   660
gtgacagaac aagccttcgg tggtgtcttt atctatgttg gtttggaccc tcttagcgat   720
tttgttaaag aattgaatat ccaagatcag gcaggatgga ttgtgacaga taaccacatg   780
aaaactgcag tcgacggtat ctttgcagtt ggagatgttc gcttgaaaga ccttcgccaa   840
gtaacaacag cggttggaga tggagctatc gctggtcaag aagcctataa attcattaca   900
gaacatagt                                                           909

<210>   2968
<211>   303
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thioredoxin reductase (trxB)
<223>   Similar to strain R6 sequence 15903354 (e-136)

<400>   2968
Met Tyr Asp Thr Ile Ile Ile Gly Ala Gly Pro Ala Gly Met Thr Ala 
1               5                   10                  15      

Ala Leu Tyr Ala Ala Arg Ser Asn Leu Lys Val Ala Leu Ile Glu Gly 
            20                  25                  30          

Gly Leu Pro Gly Gly Gln Met Asn Asn Thr Ser Asp Ile Glu Asn Tyr 
        35                  40                  45              

Pro Gly Tyr Ala Asn Ile Ser Gly Pro Glu Leu Ala Glu Lys Met Phe 
    50                  55                  60                  

Glu Pro Leu Glu Asn Leu Gly Val Glu His Ile Tyr Gly Tyr Val Glu 
65                  70                  75                  80  

Asn Val Glu Asp His Gly Asp Phe Lys Lys Val Met Thr Asp Asp Gln 
                85                  90                  95      

Thr Tyr Glu Thr Arg Thr Val Ile Val Ala Thr Gly Ser Lys His Arg 
            100                 105                 110         

Pro Leu Gly Val Pro Gly Glu Glu Glu Leu Asn Ser Arg Gly Val Ser 
        115                 120                 125             

Tyr Cys Ala Val Cys Asp Gly Ala Phe Phe Arg Asp Gln Asp Leu Leu 
    130                 135                 140                 

Val Val Gly Gly Gly Asp Ser Ala Val Glu Glu Ala Leu Phe Leu Thr 
145                 150                 155                 160 

Arg Phe Ala Lys Thr Val Thr Ile Val His Arg Arg Asp Gln Leu Arg 
                165                 170                 175     

Ala Gln Lys Val Leu Gln Asp Arg Ala Phe Ala Asn Glu Lys Ile Ser 
            180                 185                 190         

Phe Ile Trp Asp Ser Val Val Arg Glu Ile Lys Gly Glu Asn Arg Val 
        195                 200                 205             

Glu Ser Val Val Phe Glu Asn Val Lys Thr Gly Gln Val Thr Glu Gln 
    210                 215                 220                 

Ala Phe Gly Gly Val Phe Ile Tyr Val Gly Leu Asp Pro Leu Ser Asp 
225                 230                 235                 240 

Phe Val Lys Glu Leu Asn Ile Gln Asp Gln Ala Gly Trp Ile Val Thr 
                245                 250                 255     

Asp Asn His Met Lys Thr Ala Val Asp Gly Ile Phe Ala Val Gly Asp 
            260                 265                 270         

Val Arg Leu Lys Asp Leu Arg Gln Val Thr Thr Ala Val Gly Asp Gly 
        275                 280                 285             

Ala Ile Ala Gly Gln Glu Ala Tyr Lys Phe Ile Thr Glu His Ser 
    290                 295                 300             

<210>   2969
<211>   234
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2969
atgagagaaa tcatgctact gcaactattt tctttatatt tcgagagttt gatcttgacc   60
accatccttg ttctgatttt tttagggatt tggattggtc tgagagccat gtcgggagtt   120
gataagacag ccagggctcg ccaagcccat ctctatgata tgattatgat tggagtcttg   180
gttgtcccag tattatcctt tgcggttatg agtttaattc ttgttttcaa ggca         234

<210>   2970
<211>   78
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903356 (1.E-37)

<400>   2970
Met Arg Glu Ile Met Leu Leu Gln Leu Phe Ser Leu Tyr Phe Glu Ser 
1               5                   10                  15      

Leu Ile Leu Thr Thr Ile Leu Val Leu Ile Phe Leu Gly Ile Trp Ile 
            20                  25                  30          

Gly Leu Arg Ala Met Ser Gly Val Asp Lys Thr Ala Arg Ala Arg Gln 
        35                  40                  45              

Ala His Leu Tyr Asp Met Ile Met Ile Gly Val Leu Val Val Pro Val 
    50                  55                  60                  

Leu Ser Phe Ala Val Met Ser Leu Ile Leu Val Phe Lys Ala 
65                  70                  75              

<210>   2971
<211>   741
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2971
atgattaaga tttcgaattt aagcaaatcc ttttcaggac agactgtctt ggatcatctg   60
gacttggata ttcaaaaagg ggaagttgta gccttgattg gttcttcagg agctggaaaa   120
tcaacctttc ttcgcagtct caattatctt gaaacacctg acagtggctc tattcagatt   180
gatggttttt cagttgattt ttctaaaatc actcaagaag aaatccttgc cctacgtcgt   240
aagttgtcta tggttttcca acagtttaat ttgtttgaac gccgaacagc acttgataat   300
gtgaaagaag gcttggttgt tgtcaagaaa ttatctgacc aagaagcgac taagattgcc   360
aaggaagagt tggctaaggt tgggctttcg gaccgtgaaa accattatcc tcgccattta   420
tcaggtggac agaagcaacg ggttgcccta gcgcgtgcgc ttgctatgaa accagatgtt   480
ttgctcttag acgaaccaac ttcagccctt gacccagaat tggtcggtga agtagaaaag   540
tctattgcag atgctgctaa gtcaggtcag accatgattt tggtcagtca tgacatgtcc   600
tttgtagccc aagttgcgga taaaattctc ttcttagata aggggaaaat catcgagtct   660
ggaactccgg atgagattat ccacacccct aaagaagagc ggacaaaaga attcttcgct   720
agttacaaac ggacttatat t                                             741

<210>   2972
<211>   247
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903357 (e-135)

<400>   2972
Met Ile Lys Ile Ser Asn Leu Ser Lys Ser Phe Ser Gly Gln Thr Val 
1               5                   10                  15      

Leu Asp His Leu Asp Leu Asp Ile Gln Lys Gly Glu Val Val Ala Leu 
            20                  25                  30          

Ile Gly Ser Ser Gly Ala Gly Lys Ser Thr Phe Leu Arg Ser Leu Asn 
        35                  40                  45              

Tyr Leu Glu Thr Pro Asp Ser Gly Ser Ile Gln Ile Asp Gly Phe Ser 
    50                  55                  60                  

Val Asp Phe Ser Lys Ile Thr Gln Glu Glu Ile Leu Ala Leu Arg Arg 
65                  70                  75                  80  

Lys Leu Ser Met Val Phe Gln Gln Phe Asn Leu Phe Glu Arg Arg Thr 
                85                  90                  95      

Ala Leu Asp Asn Val Lys Glu Gly Leu Val Val Val Lys Lys Leu Ser 
            100                 105                 110         

Asp Gln Glu Ala Thr Lys Ile Ala Lys Glu Glu Leu Ala Lys Val Gly 
        115                 120                 125             

Leu Ser Asp Arg Glu Asn His Tyr Pro Arg His Leu Ser Gly Gly Gln 
    130                 135                 140                 

Lys Gln Arg Val Ala Leu Ala Arg Ala Leu Ala Met Lys Pro Asp Val 
145                 150                 155                 160 

Leu Leu Leu Asp Glu Pro Thr Ser Ala Leu Asp Pro Glu Leu Val Gly 
                165                 170                 175     

Glu Val Glu Lys Ser Ile Ala Asp Ala Ala Lys Ser Gly Gln Thr Met 
            180                 185                 190         

Ile Leu Val Ser His Asp Met Ser Phe Val Ala Gln Val Ala Asp Lys 
        195                 200                 205             

Ile Leu Phe Leu Asp Lys Gly Lys Ile Ile Glu Ser Gly Thr Pro Asp 
    210                 215                 220                 

Glu Ile Ile His Thr Pro Lys Glu Glu Arg Thr Lys Glu Phe Phe Ala 
225                 230                 235                 240 

Ser Tyr Lys Arg Thr Tyr Ile 
                245         

<210>   2973
<211>   798
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2973
atgaatgtta caacgatttt agcatcagat tggtaccaaa acttgatgca attgattccg   60
gatggcaagc tgtttagcct acgttcggtc tttgatggaa tccctagaat tgtccaacaa   120
cttccaacaa caattatgtt gacaattggt ggtgcccttt ttggcttggt tttggcgctt   180
ctttttgcca ttgtgaagat caatcgtgtc aagattttat atcccttgca ggccttcttt   240
gttagtttct taaaagggac accgattttg gtgcaactca tgttgaccta ctacggaatc   300
cctttggctt tgaaagccct caatcagcaa tggggaactg gtctcaatat caatgcgatt   360
ccagctgcag cttttgcgat tgtcgccttt gcctttaatg aggcagctta tgctagtgaa   420
accattcgtg cagccattct ctcagttaat cctggtgaga ttgaggcggc acgcagtctg   480
ggtatgaccc gagcgcaagt ttatcgacga gtgattattc ctaatgcagc ggtggtagct   540
actccaacct tgattaattc cctcatcggt ttgaccaagg gaacatctct agcttttagt   600
gcgggtgttg tggaagtctt tgcccaagct cagattctag gtggagctga ttatcgctat   660
tttgaacgct tcatctccgt tgcccttgtt tattgggtag tcaatatcgg aattgaaagc   720
ctcggtcgtt tcatcgagag aaaaatggct atttctgcac ctgatacagt gcaaacagat   780
gtgaaaggag accttcgt                                                 798

<210>   2974
<211>   266
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903358 (e-146)

<400>   2974
Met Asn Val Thr Thr Ile Leu Ala Ser Asp Trp Tyr Gln Asn Leu Met 
1               5                   10                  15      

Gln Leu Ile Pro Asp Gly Lys Leu Phe Ser Leu Arg Ser Val Phe Asp 
            20                  25                  30          

Gly Ile Pro Arg Ile Val Gln Gln Leu Pro Thr Thr Ile Met Leu Thr 
        35                  40                  45              

Ile Gly Gly Ala Leu Phe Gly Leu Val Leu Ala Leu Leu Phe Ala Ile 
    50                  55                  60                  

Val Lys Ile Asn Arg Val Lys Ile Leu Tyr Pro Leu Gln Ala Phe Phe 
65                  70                  75                  80  

Val Ser Phe Leu Lys Gly Thr Pro Ile Leu Val Gln Leu Met Leu Thr 
                85                  90                  95      

Tyr Tyr Gly Ile Pro Leu Ala Leu Lys Ala Leu Asn Gln Gln Trp Gly 
            100                 105                 110         

Thr Gly Leu Asn Ile Asn Ala Ile Pro Ala Ala Ala Phe Ala Ile Val 
        115                 120                 125             

Ala Phe Ala Phe Asn Glu Ala Ala Tyr Ala Ser Glu Thr Ile Arg Ala 
    130                 135                 140                 

Ala Ile Leu Ser Val Asn Pro Gly Glu Ile Glu Ala Ala Arg Ser Leu 
145                 150                 155                 160 

Gly Met Thr Arg Ala Gln Val Tyr Arg Arg Val Ile Ile Pro Asn Ala 
                165                 170                 175     

Ala Val Val Ala Thr Pro Thr Leu Ile Asn Ser Leu Ile Gly Leu Thr 
            180                 185                 190         

Lys Gly Thr Ser Leu Ala Phe Ser Ala Gly Val Val Glu Val Phe Ala 
        195                 200                 205             

Gln Ala Gln Ile Leu Gly Gly Ala Asp Tyr Arg Tyr Phe Glu Arg Phe 
    210                 215                 220                 

Ile Ser Val Ala Leu Val Tyr Trp Val Val Asn Ile Gly Ile Glu Ser 
225                 230                 235                 240 

Leu Gly Arg Phe Ile Glu Arg Lys Met Ala Ile Ser Ala Pro Asp Thr 
                245                 250                 255     

Val Gln Thr Asp Val Lys Gly Asp Leu Arg 
            260                 265     

<210>   2975
<211>   354
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2975
atgttagaat ttatcgaata ccccaaatgt tcaacttgta aaaaagcaaa acaagaatta   60
aatcaattag gtgtggacta taaagccgtc catatcgtgg aagaaacacc tagccaagaa   120
gtcattttga attggctaga aacctcagga tttgaattga agcaattttt caacaccagt   180
ggtatcaaat accgtgaatt agggctaaaa gataaggtag gaagtttgtc aaaccaagaa   240
gcggctgagt tgctagcaag tgacggtatg ttgttaaaac ggcccatttt agtagaaaat   300
ggaactgtta agcaaatcgg ttatcgaaaa tcttatgagg aactgggact gaaa         354

<210>   2976
<211>   118
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903359 (3.E-64)

<400>   2976
Met Leu Glu Phe Ile Glu Tyr Pro Lys Cys Ser Thr Cys Lys Lys Ala 
1               5                   10                  15      

Lys Gln Glu Leu Asn Gln Leu Gly Val Asp Tyr Lys Ala Val His Ile 
            20                  25                  30          

Val Glu Glu Thr Pro Ser Gln Glu Val Ile Leu Asn Trp Leu Glu Thr 
        35                  40                  45              

Ser Gly Phe Glu Leu Lys Gln Phe Phe Asn Thr Ser Gly Ile Lys Tyr 
    50                  55                  60                  

Arg Glu Leu Gly Leu Lys Asp Lys Val Gly Ser Leu Ser Asn Gln Glu 
65                  70                  75                  80  

Ala Ala Glu Leu Leu Ala Ser Asp Gly Met Leu Leu Lys Arg Pro Ile 
                85                  90                  95      

Leu Val Glu Asn Gly Thr Val Lys Gln Ile Gly Tyr Arg Lys Ser Tyr 
            100                 105                 110         

Glu Glu Leu Gly Leu Lys 
        115             

<210>   2977
<211>   528
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2977
atgcaaaaga agtatgtaaa aatcctctac tcctcaccaa ttggtattct atcacttgta   60
gctgatgacc attatttgta tggaatttgg gttcaggagc agaagcattt tgagagggga   120
ctaggagatg aaacgataga agaagttgtt agtcatccta ttttagaccc agttattgct   180
tgcttagatg attactttaa aggcaagcct caggatttat ccaacttgct cttggcgcca   240
atcggaacga attttgaaaa gagagtttgg gactatttac agggcattcc ttatggtcag   300
acagtgacct atggacaaat tgctcaagac ctgcaagtgg cttctgctca agcaattggt   360
ggagcagtgg gacgcaatcc ttggtctatc ctagtacctt gtcatcgtgt gttgggagca   420
ggcaagcgtc tgacaggtta tgctgcagga gtggaaaaga aagcttggct cttggagcat   480
gaaggagtag attttaaaga tagaagcaat agaaggagaa gcacatgt                528

<210>   2978
<211>   176
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   methylated-DNA--protein-cysteine S-methyltransferase (ogt)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903360 (e-102)

<400>   2978
Met Gln Lys Lys Tyr Val Lys Ile Leu Tyr Ser Ser Pro Ile Gly Ile 
1               5                   10                  15      

Leu Ser Leu Val Ala Asp Asp His Tyr Leu Tyr Gly Ile Trp Val Gln 
            20                  25                  30          

Glu Gln Lys His Phe Glu Arg Gly Leu Gly Asp Glu Thr Ile Glu Glu 
        35                  40                  45              

Val Val Ser His Pro Ile Leu Asp Pro Val Ile Ala Cys Leu Asp Asp 
    50                  55                  60                  

Tyr Phe Lys Gly Lys Pro Gln Asp Leu Ser Asn Leu Leu Leu Ala Pro 
65                  70                  75                  80  

Ile Gly Thr Asn Phe Glu Lys Arg Val Trp Asp Tyr Leu Gln Gly Ile 
                85                  90                  95      

Pro Tyr Gly Gln Thr Val Thr Tyr Gly Gln Ile Ala Gln Asp Leu Gln 
            100                 105                 110         

Val Ala Ser Ala Gln Ala Ile Gly Gly Ala Val Gly Arg Asn Pro Trp 
        115                 120                 125             

Ser Ile Leu Val Pro Cys His Arg Val Leu Gly Ala Gly Lys Arg Leu 
    130                 135                 140                 

Thr Gly Tyr Ala Ala Gly Val Glu Lys Lys Ala Trp Leu Leu Glu His 
145                 150                 155                 160 

Glu Gly Val Asp Phe Lys Asp Arg Ser Asn Arg Arg Arg Ser Thr Cys 
                165                 170                 175     


<210>   2979
<211>   492
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2979
atggaaattc gtttagcttt tccaaatgaa gtagatgcca tcatgcaggt gatggaggat   60
gccaaaaaat gtttagcaga tgctggtagt gaccagtggc aaaatggcta tccaaatgca   120
gatgttatta tcgatgatat catctcaggg caagcctacg tagccttgga agagggagaa   180
ctgctagcct atgctgctgt gaccaagagt ccagaggagg cctatgaagc tatttatgag   240
ggaaactggc aagctggaga gtcagagtat ctagtctttc accgtattgc tgtggcagca   300
gatgtgcagg gaaaaggagt tgctcaaacc ttcttagagg gcttgattga aggttttgat   360
tatcttgatt ttcgctcaga tacgcatgct gaaaacaagg ttatgcaaca tatttttgaa   420
aaacttggtt ttaaacaagt cggtaagatg ccagtagatg gcgaacgctt ggcctatcaa   480
aaattaaaga aa                                                       492

<210>   2980
<211>   164
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903361 (1.E-91)

<400>   2980
Met Glu Ile Arg Leu Ala Phe Pro Asn Glu Val Asp Ala Ile Met Gln 
1               5                   10                  15      

Val Met Glu Asp Ala Lys Lys Cys Leu Ala Asp Ala Gly Ser Asp Gln 
            20                  25                  30          

Trp Gln Asn Gly Tyr Pro Asn Ala Asp Val Ile Ile Asp Asp Ile Ile 
        35                  40                  45              

Ser Gly Gln Ala Tyr Val Ala Leu Glu Glu Gly Glu Leu Leu Ala Tyr 
    50                  55                  60                  

Ala Ala Val Thr Lys Ser Pro Glu Glu Ala Tyr Glu Ala Ile Tyr Glu 
65                  70                  75                  80  

Gly Asn Trp Gln Ala Gly Glu Ser Glu Tyr Leu Val Phe His Arg Ile 
                85                  90                  95      

Ala Val Ala Ala Asp Val Gln Gly Lys Gly Val Ala Gln Thr Phe Leu 
            100                 105                 110         

Glu Gly Leu Ile Glu Gly Phe Asp Tyr Leu Asp Phe Arg Ser Asp Thr 
        115                 120                 125             

His Ala Glu Asn Lys Val Met Gln His Ile Phe Glu Lys Leu Gly Phe 
    130                 135                 140                 

Lys Gln Val Gly Lys Met Pro Val Asp Gly Glu Arg Leu Ala Tyr Gln 
145                 150                 155                 160 

Lys Leu Lys Lys 
                

<210>   2981
<211>   444
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2981
atgaaaacta ccttttccta cccaaaatgg gcagaaattc caaacattga cctctatctg   60
gaccaggttt tgctctatgt caatcaggtc tgcgccccta tctctcctaa taaagacaag   120
ggcctaacag catctatggt caacaattat gtgaaaaatg gttacctgac aaagcctgac   180
aaaaaaaaat accaacgcca acagattgcc cgtttgattg ctatcacaac cctcaagtct   240
gtattttcta ttcaagaaat agcccagaca cttaatactc tacaaactca agcaagttca   300
gaccaactct acgatgcttt tgtggactac atgaaccaag gaattgaccc agctaaccct   360
attatccaaa ccagctgcca aaccgttaaa ctctatcatc aaactctaga cttaatcgat   420
catactcaag aggaggtaat ccaa                                          444

<210>   2982
<211>   148
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903362 (6.E-83)

<400>   2982
Met Lys Thr Thr Phe Ser Tyr Pro Lys Trp Ala Glu Ile Pro Asn Ile 
1               5                   10                  15      

Asp Leu Tyr Leu Asp Gln Val Leu Leu Tyr Val Asn Gln Val Cys Ala 
            20                  25                  30          

Pro Ile Ser Pro Asn Lys Asp Lys Gly Leu Thr Ala Ser Met Val Asn 
        35                  40                  45              

Asn Tyr Val Lys Asn Gly Tyr Leu Thr Lys Pro Asp Lys Lys Lys Tyr 
    50                  55                  60                  

Gln Arg Gln Gln Ile Ala Arg Leu Ile Ala Ile Thr Thr Leu Lys Ser 
65                  70                  75                  80  

Val Phe Ser Ile Gln Glu Ile Ala Gln Thr Leu Asn Thr Leu Gln Thr 
                85                  90                  95      

Gln Ala Ser Ser Asp Gln Leu Tyr Asp Ala Phe Val Asp Tyr Met Asn 
            100                 105                 110         

Gln Gly Ile Asp Pro Ala Asn Pro Ile Ile Gln Thr Ser Cys Gln Thr 
        115                 120                 125             

Val Lys Leu Tyr His Gln Thr Leu Asp Leu Ile Asp His Thr Gln Glu 
    130                 135                 140                 

Glu Val Ile Gln 
145             

<210>   2983
<211>   645
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2983
atgaacacta gtcttaaact cagcaaacaa ctcagttttg gagaggagat tgctaatagc   60
gtgacccatg ctgtgggtgc agtcatcatg cttatcttgc tgcctatttc atccatctat   120
agttatgaag cacacggatt tttatcctct atcggcgttt ccattttcgt catcagtctc   180
tttctcatgt tcctatcatc caccatttat cactctatgg cctatggttc gacccacaaa   240
tatgttttgc gaatcattga ccattctatg atttacgttg ccattgccgg ctcatacacg   300
cccgttgtct tgaccttgat gaataactgg tttggctatc tgattattgt catccaatgg   360
ggaacgacca tctttggtat tctctataaa atctttgcta aaaaggtcaa tgagaaattt   420
agccttgctc tttacctgat tatgggctgg ttggttctgg ctatcattcc tgccattatc   480
agtcaaacga cacccgtttt ctggagtctc atggtaactg gcggactctg ttatacagtt   540
ggagctggat tttatgccaa gaaaaaacct tatttccaca tgatttggca tctctttatc   600
ctagctgcgt ccgcacttca atacatcgct attgtttatt acatg                   645

<210>   2984
<211>   215
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hemolysin
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903363 (e-121)

<400>   2984
Met Asn Thr Ser Leu Lys Leu Ser Lys Gln Leu Ser Phe Gly Glu Glu 
1               5                   10                  15      

Ile Ala Asn Ser Val Thr His Ala Val Gly Ala Val Ile Met Leu Ile 
            20                  25                  30          

Leu Leu Pro Ile Ser Ser Ile Tyr Ser Tyr Glu Ala His Gly Phe Leu 
        35                  40                  45              

Ser Ser Ile Gly Val Ser Ile Phe Val Ile Ser Leu Phe Leu Met Phe 
    50                  55                  60                  

Leu Ser Ser Thr Ile Tyr His Ser Met Ala Tyr Gly Ser Thr His Lys 
65                  70                  75                  80  

Tyr Val Leu Arg Ile Ile Asp His Ser Met Ile Tyr Val Ala Ile Ala 
                85                  90                  95      

Gly Ser Tyr Thr Pro Val Val Leu Thr Leu Met Asn Asn Trp Phe Gly 
            100                 105                 110         

Tyr Leu Ile Ile Val Ile Gln Trp Gly Thr Thr Ile Phe Gly Ile Leu 
        115                 120                 125             

Tyr Lys Ile Phe Ala Lys Lys Val Asn Glu Lys Phe Ser Leu Ala Leu 
    130                 135                 140                 

Tyr Leu Ile Met Gly Trp Leu Val Leu Ala Ile Ile Pro Ala Ile Ile 
145                 150                 155                 160 

Ser Gln Thr Thr Pro Val Phe Trp Ser Leu Met Val Thr Gly Gly Leu 
                165                 170                 175     

Cys Tyr Thr Val Gly Ala Gly Phe Tyr Ala Lys Lys Lys Pro Tyr Phe 
            180                 185                 190         

His Met Ile Trp His Leu Phe Ile Leu Ala Ala Ser Ala Leu Gln Tyr 
        195                 200                 205             

Ile Ala Ile Val Tyr Tyr Met 
    210                 215 

<210>   2985
<211>   579
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2985
atgaaaatcg gaatattggc cttgcaaggg gcctttgcag aacatgcaaa agtgctagat   60
caattaggtg tcgagagtgt agaactcaga aatctagatg attttcagca agatcagagt   120
gacttgtcgg gtttgatttt gcctggtggt gagtctacaa ccatgggcaa gctcttacgt   180
gaccagaaca tgctacttcc catccgagaa gccattctat ctggcttacc agtgtttggg   240
acctgtgcgg gcttaatttt gctggctaag gaaatcactt ctcagaaaga gagtcatcta   300
ggaactatgg atatggtggt cgagcgtaat gcttatgggc gccaattagg aagtttctac   360
acggaagcag aatgtaaggg agttggcaag attccaatga cctttatccg tggtccgatt   420
atcagtagtg ttggtgaggg tgtagaaatt ttagcaacag tgaacaatca aattgttgca   480
gcccaagaaa aaaatatgtt ggtaagttct tttcatccag aattgactga tgatgtgcgc   540
ttgcaccagt actttatcaa tatgtgtaaa gaaaaaagt                          579

<210>   2986
<211>   193
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903364 (e-106)

<400>   2986
Met Lys Ile Gly Ile Leu Ala Leu Gln Gly Ala Phe Ala Glu His Ala 
1               5                   10                  15      

Lys Val Leu Asp Gln Leu Gly Val Glu Ser Val Glu Leu Arg Asn Leu 
            20                  25                  30          

Asp Asp Phe Gln Gln Asp Gln Ser Asp Leu Ser Gly Leu Ile Leu Pro 
        35                  40                  45              

Gly Gly Glu Ser Thr Thr Met Gly Lys Leu Leu Arg Asp Gln Asn Met 
    50                  55                  60                  

Leu Leu Pro Ile Arg Glu Ala Ile Leu Ser Gly Leu Pro Val Phe Gly 
65                  70                  75                  80  

Thr Cys Ala Gly Leu Ile Leu Leu Ala Lys Glu Ile Thr Ser Gln Lys 
                85                  90                  95      

Glu Ser His Leu Gly Thr Met Asp Met Val Val Glu Arg Asn Ala Tyr 
            100                 105                 110         

Gly Arg Gln Leu Gly Ser Phe Tyr Thr Glu Ala Glu Cys Lys Gly Val 
        115                 120                 125             

Gly Lys Ile Pro Met Thr Phe Ile Arg Gly Pro Ile Ile Ser Ser Val 
    130                 135                 140                 

Gly Glu Gly Val Glu Ile Leu Ala Thr Val Asn Asn Gln Ile Val Ala 
145                 150                 155                 160 

Ala Gln Glu Lys Asn Met Leu Val Ser Ser Phe His Pro Glu Leu Thr 
                165                 170                 175     

Asp Asp Val Arg Leu His Gln Tyr Phe Ile Asn Met Cys Lys Glu Lys 
            180                 185                 190         

Ser 
    

<210>   2987
<211>   891
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2987
atgatgagga taaaacaaat gactgaaaat cgttatgaac taaataaaaa cttggcacag   60
atgctcaagg gtggtgttat tatggatgtg cagaatcctg aacaggctcg tatcgcagaa   120
gctgctggtg cggcagctgt gatggccttg gaacgaattc cggctgatat tcgtgcagct   180
ggaggagttt cccgcatgag cgacccaaag atgattaagg aaatccaaga agcggttagt   240
attccagtaa tggctaaggt cagaatcggg cattttgttg aagctcagat tttagaggct   300
attgaaattg attatatcga cgagagtgaa gttctatctc cagctgatga ccgtttccat   360
gtggacaaga aagaattcca agttcctttt gtctgtggtg ctaaggattt gggtgaagcc   420
ttgcgtcgta tcgctgaagg tgcttccatg attcgtacca aaggagaacc agggacaggg   480
gatatcgtcc aagctgttcg tcatatgcgt atgatgaatc aggaaattcg ccgcattcaa   540
aacttacgtg aggacgagct ttatgttgct gccaaggatt tgcaagtccc tgtagaattg   600
gtccaatatg ttcatgaaca tggaaaattg ccagttgtaa atttcgctgc tggaggtgtt   660
gcaacgccag cagatgctgc gttaatgatg caattagggg cagagggggt ctttgtcggt   720
tcaggtattt tcaagtcagg agatcctgtt aaacgagcga gtgccattgt taaggctgtg   780
actaacttcc gtaatcctca aatcctagct caaatctctg aagatttagg agaagccatg   840
gttggtatta atgaaaatga aatccaaatt ctcatggctg aacgaggaaa a            891

<210>   2988
<211>   297
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyridoxine biosynthesis protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903365 (e-161)

<400>   2988
Met Met Arg Ile Lys Gln Met Thr Glu Asn Arg Tyr Glu Leu Asn Lys 
1               5                   10                  15      

Asn Leu Ala Gln Met Leu Lys Gly Gly Val Ile Met Asp Val Gln Asn 
            20                  25                  30          

Pro Glu Gln Ala Arg Ile Ala Glu Ala Ala Gly Ala Ala Ala Val Met 
        35                  40                  45              

Ala Leu Glu Arg Ile Pro Ala Asp Ile Arg Ala Ala Gly Gly Val Ser 
    50                  55                  60                  

Arg Met Ser Asp Pro Lys Met Ile Lys Glu Ile Gln Glu Ala Val Ser 
65                  70                  75                  80  

Ile Pro Val Met Ala Lys Val Arg Ile Gly His Phe Val Glu Ala Gln 
                85                  90                  95      

Ile Leu Glu Ala Ile Glu Ile Asp Tyr Ile Asp Glu Ser Glu Val Leu 
            100                 105                 110         

Ser Pro Ala Asp Asp Arg Phe His Val Asp Lys Lys Glu Phe Gln Val 
        115                 120                 125             

Pro Phe Val Cys Gly Ala Lys Asp Leu Gly Glu Ala Leu Arg Arg Ile 
    130                 135                 140                 

Ala Glu Gly Ala Ser Met Ile Arg Thr Lys Gly Glu Pro Gly Thr Gly 
145                 150                 155                 160 

Asp Ile Val Gln Ala Val Arg His Met Arg Met Met Asn Gln Glu Ile 
                165                 170                 175     

Arg Arg Ile Gln Asn Leu Arg Glu Asp Glu Leu Tyr Val Ala Ala Lys 
            180                 185                 190         

Asp Leu Gln Val Pro Val Glu Leu Val Gln Tyr Val His Glu His Gly 
        195                 200                 205             

Lys Leu Pro Val Val Asn Phe Ala Ala Gly Gly Val Ala Thr Pro Ala 
    210                 215                 220                 

Asp Ala Ala Leu Met Met Gln Leu Gly Ala Glu Gly Val Phe Val Gly 
225                 230                 235                 240 

Ser Gly Ile Phe Lys Ser Gly Asp Pro Val Lys Arg Ala Ser Ala Ile 
                245                 250                 255     

Val Lys Ala Val Thr Asn Phe Arg Asn Pro Gln Ile Leu Ala Gln Ile 
            260                 265                 270         

Ser Glu Asp Leu Gly Glu Ala Met Val Gly Ile Asn Glu Asn Glu Ile 
        275                 280                 285             

Gln Ile Leu Met Ala Glu Arg Gly Lys 
    290                 295         

<210>   2989
<211>   1377
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2989
atgagtaaaa tcgttgtagt cggtgctaac cacgctggta cagcatgtat caataccatg   60
ttggataatt ttggaaatga gaacgaaatt gttgtatttg accaaaactc taacatctct   120
ttcctaggat gtggaatggc tctttggatt ggtgaacaaa ttgacggtgc tgaaggcttg   180
ttctattctg ataaagaaaa attggaagct aaaggtgcta aagtttacat gaactcacct   240
gttctttcaa tcgactatga taacaaagta gttacagcgg aagttgaagg aaaagagcac   300
aaagaatcat acgaaaaatt gattttcgct acaggctcta caccaatctt gccaccaatc   360
gaaggtgttg aaattgttaa aggaaaccgc gaatttaaag caactcttga aaacgtacaa   420
ttcgtgaaat tgtaccaaaa tgctgaagaa gttatcaata aactttctga caagagccaa   480
cacctcgacc gtatcgccgt tgttggtggt ggttacatcg gtgttgaact tgctgaagcc   540
tttgaacgtc ttggaaaaga agttgtcctt gttgatatcg ttgatactgt cttgaacggt   600
tactatgaca aagacttcac acaaatgatg gcgaagaact tggaagatca caacatccgc   660
ttggctctag gtcaaactgt taaagcaatc gaaggtgacg gtaaagttga acgcttgatt   720
actgacaaag aaagctttga cgtggatatg gttatccttg cagttggttt ccgtccaaac   780
acagcccttg caggtggtaa gatcgaactc ttccgcaacg gtgccttcct tgtagacaag   840
aaacaagaaa catctatccc agacgtttac gctgttggtg actgtgcgac tgtttatgac   900
aatgctcgta aagatacaag ctatatcgct cttgcttcaa atgctgttcg cactggtatc   960
gttggtgcct acaatgcttg tggacatgaa ttggaaggaa tcggtgttca aggttcaaat   1020
ggtatctcaa tctacggtct tcacatggtt tcaactggtt tgactcttga aaaagcgaaa   1080
gctgctggtt acaacgcaac tgaaacaggc tttaacgatc ttcaaaaacc agaattcatg   1140
aaacatgaca accatgaagt agcaattaag attgtctttg acaaagatag ccgtgaaatt   1200
cttggtgccc aaatggtttc acatgatatt gcaattagca tgggaatcca catgttctca   1260
cttgctatcc aagagcatgt gacaattgat aaattggcat tgacagacct cttcttcttg   1320
ccacacttca acaaaccata caactacatc acaatggctg cccttacggc tgaaaaa      1377

<210>   2990
<211>   459
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   NADH oxidase (nox)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903366 (0.E+01)

<400>   2990
Met Ser Lys Ile Val Val Val Gly Ala Asn His Ala Gly Thr Ala Cys 
1               5                   10                  15      

Ile Asn Thr Met Leu Asp Asn Phe Gly Asn Glu Asn Glu Ile Val Val 
            20                  25                  30          

Phe Asp Gln Asn Ser Asn Ile Ser Phe Leu Gly Cys Gly Met Ala Leu 
        35                  40                  45              

Trp Ile Gly Glu Gln Ile Asp Gly Ala Glu Gly Leu Phe Tyr Ser Asp 
    50                  55                  60                  

Lys Glu Lys Leu Glu Ala Lys Gly Ala Lys Val Tyr Met Asn Ser Pro 
65                  70                  75                  80  

Val Leu Ser Ile Asp Tyr Asp Asn Lys Val Val Thr Ala Glu Val Glu 
                85                  90                  95      

Gly Lys Glu His Lys Glu Ser Tyr Glu Lys Leu Ile Phe Ala Thr Gly 
            100                 105                 110         

Ser Thr Pro Ile Leu Pro Pro Ile Glu Gly Val Glu Ile Val Lys Gly 
        115                 120                 125             

Asn Arg Glu Phe Lys Ala Thr Leu Glu Asn Val Gln Phe Val Lys Leu 
    130                 135                 140                 

Tyr Gln Asn Ala Glu Glu Val Ile Asn Lys Leu Ser Asp Lys Ser Gln 
145                 150                 155                 160 

His Leu Asp Arg Ile Ala Val Val Gly Gly Gly Tyr Ile Gly Val Glu 
                165                 170                 175     

Leu Ala Glu Ala Phe Glu Arg Leu Gly Lys Glu Val Val Leu Val Asp 
            180                 185                 190         

Ile Val Asp Thr Val Leu Asn Gly Tyr Tyr Asp Lys Asp Phe Thr Gln 
        195                 200                 205             

Met Met Ala Lys Asn Leu Glu Asp His Asn Ile Arg Leu Ala Leu Gly 
    210                 215                 220                 

Gln Thr Val Lys Ala Ile Glu Gly Asp Gly Lys Val Glu Arg Leu Ile 
225                 230                 235                 240 

Thr Asp Lys Glu Ser Phe Asp Val Asp Met Val Ile Leu Ala Val Gly 
                245                 250                 255     

Phe Arg Pro Asn Thr Ala Leu Ala Gly Gly Lys Ile Glu Leu Phe Arg 
            260                 265                 270         

Asn Gly Ala Phe Leu Val Asp Lys Lys Gln Glu Thr Ser Ile Pro Asp 
        275                 280                 285             

Val Tyr Ala Val Gly Asp Cys Ala Thr Val Tyr Asp Asn Ala Arg Lys 
    290                 295                 300                 

Asp Thr Ser Tyr Ile Ala Leu Ala Ser Asn Ala Val Arg Thr Gly Ile 
305                 310                 315                 320 

Val Gly Ala Tyr Asn Ala Cys Gly His Glu Leu Glu Gly Ile Gly Val 
                325                 330                 335     

Gln Gly Ser Asn Gly Ile Ser Ile Tyr Gly Leu His Met Val Ser Thr 
            340                 345                 350         

Gly Leu Thr Leu Glu Lys Ala Lys Ala Ala Gly Tyr Asn Ala Thr Glu 
        355                 360                 365             

Thr Gly Phe Asn Asp Leu Gln Lys Pro Glu Phe Met Lys His Asp Asn 
    370                 375                 380                 

His Glu Val Ala Ile Lys Ile Val Phe Asp Lys Asp Ser Arg Glu Ile 
385                 390                 395                 400 

Leu Gly Ala Gln Met Val Ser His Asp Ile Ala Ile Ser Met Gly Ile 
                405                 410                 415     


His Met Phe Ser Leu Ala Ile Gln Glu His Val Thr Ile Asp Lys Leu 
            420                 425                 430         

Ala Leu Thr Asp Leu Phe Phe Leu Pro His Phe Asn Lys Pro Tyr Asn 
        435                 440                 445             

Tyr Ile Thr Met Ala Ala Leu Thr Ala Glu Lys 
    450                 455                 

<210>   2991
<211>   921
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2991
ttgactcttc gttcacattc tgaacggcta atggggacta ctatcactat ttcattagtg   60
gatgagcaag ccgatatctt tctccaaaaa tcctttgact tgctcaaaga acttgaatac   120
cgcttcaacg ccaatagtca agaatctgag ttgatggaaa tcaattatca agcaggaata   180
gcccccgtca cggttcatcc agacctgttt gagctgattt cacttgggtt agagcatagc   240
ctagcgctct ctagccacct caatatcagc attggtccct taattcaaac ctggcgtatc   300
ggtttttcag atgccaaggt cgcccagcct caagaaattg aatcggtgct gcctctaatc   360
aatcctcatg gtatcgagtt agattcttct acttctactg tgtttttaaa acagaaagga   420
atgaagatcg atctaggttg tttagccaaa ggatacagtg cggataaggt tgcccaattt   480
cttaggaaag agggggtgac ttctgccttg atcaatctgg gagggaatat cctgaccatt   540
ggaaaaaatc aggcaagagg ggataaccca tggcaaatcg ggattcaaga cccagccaat   600
cctaggggaa atcatttaat gaccatccct gttgtcaata aatctgtcgt gacttcaggc   660
atttatgaac gtcacctgac cgtcgatgga caagattacc atcacatttt tgacagtcaa   720
acaggatatc ctgttgaaac ggaactagcg agtctaacaa tcatctctga taaatcagtc   780
gatggcgaaa tctggacgac tcgactcttt ggagaaagac ctgcttctat cctctggcaa   840
gtcgaaagtt tggagggcat cgaagtcatc ctcatcgata aagaaggcca cctaagctgt   900
tcttcaggaa ttcctactct a                                             921

<210>   2992
<211>   307
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thiamine biosynthesis protein ApbE, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903367 (e-176)

<400>   2992
Met Thr Leu Arg Ser His Ser Glu Arg Leu Met Gly Thr Thr Ile Thr 
1               5                   10                  15      

Ile Ser Leu Val Asp Glu Gln Ala Asp Ile Phe Leu Gln Lys Ser Phe 
            20                  25                  30          

Asp Leu Leu Lys Glu Leu Glu Tyr Arg Phe Asn Ala Asn Ser Gln Glu 
        35                  40                  45              

Ser Glu Leu Met Glu Ile Asn Tyr Gln Ala Gly Ile Ala Pro Val Thr 
    50                  55                  60                  

Val His Pro Asp Leu Phe Glu Leu Ile Ser Leu Gly Leu Glu His Ser 
65                  70                  75                  80  

Leu Ala Leu Ser Ser His Leu Asn Ile Ser Ile Gly Pro Leu Ile Gln 
                85                  90                  95      

Thr Trp Arg Ile Gly Phe Ser Asp Ala Lys Val Ala Gln Pro Gln Glu 
            100                 105                 110         

Ile Glu Ser Val Leu Pro Leu Ile Asn Pro His Gly Ile Glu Leu Asp 
        115                 120                 125             

Ser Ser Thr Ser Thr Val Phe Leu Lys Gln Lys Gly Met Lys Ile Asp 
    130                 135                 140                 

Leu Gly Cys Leu Ala Lys Gly Tyr Ser Ala Asp Lys Val Ala Gln Phe 
145                 150                 155                 160 

Leu Arg Lys Glu Gly Val Thr Ser Ala Leu Ile Asn Leu Gly Gly Asn 
                165                 170                 175     

Ile Leu Thr Ile Gly Lys Asn Gln Ala Arg Gly Asp Asn Pro Trp Gln 
            180                 185                 190         

Ile Gly Ile Gln Asp Pro Ala Asn Pro Arg Gly Asn His Leu Met Thr 
        195                 200                 205             

Ile Pro Val Val Asn Lys Ser Val Val Thr Ser Gly Ile Tyr Glu Arg 

    210                 215                 220                 

His Leu Thr Val Asp Gly Gln Asp Tyr His His Ile Phe Asp Ser Gln 
225                 230                 235                 240 

Thr Gly Tyr Pro Val Glu Thr Glu Leu Ala Ser Leu Thr Ile Ile Ser 
                245                 250                 255     

Asp Lys Ser Val Asp Gly Glu Ile Trp Thr Thr Arg Leu Phe Gly Glu 
            260                 265                 270         

Arg Pro Ala Ser Ile Leu Trp Gln Val Glu Ser Leu Glu Gly Ile Glu 
        275                 280                 285             

Val Ile Leu Ile Asp Lys Glu Gly His Leu Ser Cys Ser Ser Gly Ile 
    290                 295                 300                 

Pro Thr Leu 
305         


<210>   2993
<211>   603
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2993
atgttaaaac ttattgctat tgttggaaca aattcaaaac gttctacaaa ccgtcaattg   60
cttcaataca tgcaaaaaca ctttactgac aaagctgaaa ttgaacttgt tgaaatcaag   120
gccattcctg tcttcaacaa accagctgac aagcaagtac ctgctgaaat attggaaatt   180
gctgctaaaa tcgaagaggc agatggcgtt attatcggta ctcctgagta tgatcactct   240
attccagctg ttttgatgag cgctcttgct tggttgtctt atggtattta cccacttttg   300
aacaaaccaa tcatgattac aggtgcttct tacggtacgc ttggttcatc tcgtgcccaa   360
ttgcaacttc gtcaaatctt gaatgctcct gaaatcaagg caaatgttct tccagatgaa   420
ttcttgctct cacactctct tcaagcattt aacccaagtg gcgacttggt tgaccttgat   480
gttatcaaga aattggatgc catctttgat gacttccgta tctttgtaaa aatcacagaa   540
aaattacgta atgcacaaga attacttcgc aaagatgctg aagactttga ctgggaaaat   600
ttg                                                                 603

<210>   2994
<211>   201
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903368 (e-110)

<400>   2994
Met Leu Lys Leu Ile Ala Ile Val Gly Thr Asn Ser Lys Arg Ser Thr 
1               5                   10                  15      

Asn Arg Gln Leu Leu Gln Tyr Met Gln Lys His Phe Thr Asp Lys Ala 
            20                  25                  30          

Glu Ile Glu Leu Val Glu Ile Lys Ala Ile Pro Val Phe Asn Lys Pro 
        35                  40                  45              

Ala Asp Lys Gln Val Pro Ala Glu Ile Leu Glu Ile Ala Ala Lys Ile 
    50                  55                  60                  

Glu Glu Ala Asp Gly Val Ile Ile Gly Thr Pro Glu Tyr Asp His Ser 
65                  70                  75                  80  

Ile Pro Ala Val Leu Met Ser Ala Leu Ala Trp Leu Ser Tyr Gly Ile 
                85                  90                  95      

Tyr Pro Leu Leu Asn Lys Pro Ile Met Ile Thr Gly Ala Ser Tyr Gly 
            100                 105                 110         

Thr Leu Gly Ser Ser Arg Ala Gln Leu Gln Leu Arg Gln Ile Leu Asn 
        115                 120                 125             

Ala Pro Glu Ile Lys Ala Asn Val Leu Pro Asp Glu Phe Leu Leu Ser 
    130                 135                 140                 

His Ser Leu Gln Ala Phe Asn Pro Ser Gly Asp Leu Val Asp Leu Asp 
145                 150                 155                 160 

Val Ile Lys Lys Leu Asp Ala Ile Phe Asp Asp Phe Arg Ile Phe Val 
                165                 170                 175     

Lys Ile Thr Glu Lys Leu Arg Asn Ala Gln Glu Leu Leu Arg Lys Asp 
            180                 185                 190         

Ala Glu Asp Phe Asp Trp Glu Asn Leu 
        195                 200     

<210>   2995
<211>   1242
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2995
atgaaatttg ttggacttgt tggatcaaac tacgatcaat catataaccg taagctcttg   60
gaatttatcc gtcgctactt caaactcaaa tttgaattag aagttcttga aattgacgaa   120
gttccaatgt ttaaccaaga tgaaaaatgg gatgaaagtt tccaattacg ttatttatat   180
aacaaaatta ctcgtgcaga tggtgttatc attgctactc ctgagcataa ccacactatc   240
tcagcttcac tcaaatctgt acttgaatgg ctttcatacg aagttcatcc atttgaaaac   300
aagcctgtta tgattgtggg tgcatcatac tatgaccaag gaacatcacg tgctcaagtt   360
caccttcgta aaatccttga tgctccaggt gttaatgcct acacgcttcc aggtaacgaa   420
ttccttcttg gtaaagctaa ggaagctttt gataacaacg gaaatatcac caacgaaggc   480
actgttaaat tccttgaaac ttgcttagat aactttgtta aatacgtagg agtcgtttcg   540
aaattgaaaa aaccaaaacc aatcgaatca gaagacttgg attgtggaaa accaatcgct   600
acaaccatca cagaagttga ccctgacgat ccagaatggg tagaaaaagt tgcagcattc   660
actggtgctg tttctggtga tacctatgtc aaattggacc acggtatcct aacagttaac   720
caaattgata tgttcttgaa agctatgcca tttgaattga catacgctga cgacaacaac   780
caattcctct actacaacaa cgctcaccaa gatccagaca ctatgttcgc taaacgtgta   840
ccacctcaat caggtagccg tatgtcgact gttcatggtt ctcttccacc agcacgtatg   900
aagaacgtag agtgggttat cggaacactt cgcaacggaa accaagaata cgtccgtacg   960
atcgttccag gttctcctgc aggtgttatc aacactcaca actaccaagc aatgtactat   1020
cctgatggat catacgctgg tatcaatgaa atcgtcttta acttccaacc atggcttgac   1080
tggtacctaa aagagactgg tcaacgtttg gtgggtggta gcggaccatt tgctcctgct   1140
gccggaggtc atggagacgc cgatgctact tctggcgctt ctgattcagg ggatgctgga   1200
ggccacggtg gtgacgcaga cgctacagcc ggtgcaagtt ac                      1242

<210>   2996
<211>   414
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903369 (0.E+01)

<400>   2996
Met Lys Phe Val Gly Leu Val Gly Ser Asn Tyr Asp Gln Ser Tyr Asn 
1               5                   10                  15      


Arg Lys Leu Leu Glu Phe Ile Arg Arg Tyr Phe Lys Leu Lys Phe Glu 
            20                  25                  30          

Leu Glu Val Leu Glu Ile Asp Glu Val Pro Met Phe Asn Gln Asp Glu 
        35                  40                  45              

Lys Trp Asp Glu Ser Phe Gln Leu Arg Tyr Leu Tyr Asn Lys Ile Thr 
    50                  55                  60                  

Arg Ala Asp Gly Val Ile Ile Ala Thr Pro Glu His Asn His Thr Ile 
65                  70                  75                  80  

Ser Ala Ser Leu Lys Ser Val Leu Glu Trp Leu Ser Tyr Glu Val His 
                85                  90                  95      

Pro Phe Glu Asn Lys Pro Val Met Ile Val Gly Ala Ser Tyr Tyr Asp 
            100                 105                 110         

Gln Gly Thr Ser Arg Ala Gln Val His Leu Arg Lys Ile Leu Asp Ala 
        115                 120                 125             

Pro Gly Val Asn Ala Tyr Thr Leu Pro Gly Asn Glu Phe Leu Leu Gly 
    130                 135                 140                 

Lys Ala Lys Glu Ala Phe Asp Asn Asn Gly Asn Ile Thr Asn Glu Gly 
145                 150                 155                 160 

Thr Val Lys Phe Leu Glu Thr Cys Leu Asp Asn Phe Val Lys Tyr Val 
                165                 170                 175     

Gly Val Val Ser Lys Leu Lys Lys Pro Lys Pro Ile Glu Ser Glu Asp 
            180                 185                 190         

Leu Asp Cys Gly Lys Pro Ile Ala Thr Thr Ile Thr Glu Val Asp Pro 
        195                 200                 205             

Asp Asp Pro Glu Trp Val Glu Lys Val Ala Ala Phe Thr Gly Ala Val 
    210                 215                 220                 

Ser Gly Asp Thr Tyr Val Lys Leu Asp His Gly Ile Leu Thr Val Asn 
225                 230                 235                 240 

Gln Ile Asp Met Phe Leu Lys Ala Met Pro Phe Glu Leu Thr Tyr Ala 
                245                 250                 255     

Asp Asp Asn Asn Gln Phe Leu Tyr Tyr Asn Asn Ala His Gln Asp Pro 
            260                 265                 270         

Asp Thr Met Phe Ala Lys Arg Val Pro Pro Gln Ser Gly Ser Arg Met 
        275                 280                 285             

Ser Thr Val His Gly Ser Leu Pro Pro Ala Arg Met Lys Asn Val Glu 
    290                 295                 300                 

Trp Val Ile Gly Thr Leu Arg Asn Gly Asn Gln Glu Tyr Val Arg Thr 
305                 310                 315                 320 

Ile Val Pro Gly Ser Pro Ala Gly Val Ile Asn Thr His Asn Tyr Gln 
                325                 330                 335     

Ala Met Tyr Tyr Pro Asp Gly Ser Tyr Ala Gly Ile Asn Glu Ile Val 
            340                 345                 350         


Phe Asn Phe Gln Pro Trp Leu Asp Trp Tyr Leu Lys Glu Thr Gly Gln 
        355                 360                 365             

Arg Leu Val Gly Gly Ser Gly Pro Phe Ala Pro Ala Ala Gly Gly His 
    370                 375                 380                 

Gly Asp Ala Asp Ala Thr Ser Gly Ala Ser Asp Ser Gly Asp Ala Gly 
385                 390                 395                 400 

Gly His Gly Gly Asp Ala Asp Ala Thr Ala Gly Ala Ser Tyr 
                405                 410                 

<210>   2997
<211>   255
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2997
atggatccga aaaaaattgc tcgtatcaat gagcttgcta aaaagaaaaa aacagaaggc   60
ttaacaccag aagaaaaagt ggaacaagcc aaactacgtg aggagtacat cgaaggttat   120
cgccgcgctg ttcgtcacca cattgaagga atcaaaattg tggacgaaga aggaaacgat   180
gttacaccag aaaaactacg ccaagtacaa cgtgaaaaag gattacatgg ccgtagtctt   240
gatgatccaa attca                                                    255

<210>   2998
<211>   85
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903370 (2.E-45)

<400>   2998
Met Asp Pro Lys Lys Ile Ala Arg Ile Asn Glu Leu Ala Lys Lys Lys 
1               5                   10                  15      

Lys Thr Glu Gly Leu Thr Pro Glu Glu Lys Val Glu Gln Ala Lys Leu 
            20                  25                  30          

Arg Glu Glu Tyr Ile Glu Gly Tyr Arg Arg Ala Val Arg His His Ile 
        35                  40                  45              

Glu Gly Ile Lys Ile Val Asp Glu Glu Gly Asn Asp Val Thr Pro Glu 
    50                  55                  60                  

Lys Leu Arg Gln Val Gln Arg Glu Lys Gly Leu His Gly Arg Ser Leu 
65                  70                  75                  80  

Asp Asp Pro Asn Ser 
                85  

<210>   2999
<211>   2034
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   2999
atgacaaaaa acttattagt agaactcggt cttgaagaat taccagccta tgttgttacg   60
ccaagtgaaa aacaactagg cgaaaaaatg gcagccttcc tcaagggaaa acgcctgtct   120
tttgaagcca ttcaaacttt ctcaacacca cgtcgtttgg ctgttcgtgt aactggtctt   180
gcagacaaac agtctgattt aacagaagat ttcaagggtc cagcaaagaa aattgcctta   240
gatagtgatg gaaacttcac caaagcagct caaggatttg tccgtgggaa aggtttgact   300
gttgaagata tcgaattccg tgaaatcaag ggtgaagaat atgtctatgt cactaaggaa   360
gaaattggtc aagcagttga agccattgtt ccaggcattg tggatgtctt gaagtcactg   420
actttccctg tcagcatgca ctgggcggga aatagctttg aatacatccg ccctgttcac   480
actttaactg ttctcttgga tgagcaagag tttgacttgg atttccttga tatcaaggga   540
agtcgtgtga gtcgtggcca tcgttttttg ggacaagaaa ccaagattca gtcagcattg   600
agctatgaag aagaccttcg taagcagttt gtaatcgcag atccatgtga acgtgagcaa   660
atgattgttg accaaatcaa ggaaattgag gcaaaacatg gtgtacgtat cgaaattgat   720
gcggatttgc tgaatgaagt cttgaatttg gttgaatacc caactgcctt catgggaagt   780
tttgatgcta aataccttga agttccagaa gaagtcttgg tgacttctat gaaggaacac   840
cagcgttact ttgttgttcg tgatcaagat ggaaaactct tgccaaactt catttctgtt   900
cgtaacggaa acgcagagcg tttgaaaaat gtcatcaaag gaaatgaaaa agtcttggta   960
gcccgcttgg aagacggaga attcttctgg cgtgaagacc aaaaattggt gatttcagat   1020
cttgttgaaa aattaaacaa tgtcaccttc catgagaaga ttggttctct tcgtgaacac   1080
atgattcgta cgggtcaaat cactgtactt ttggcagaaa aagctagttt gtcagtggat   1140
gaaacagttg accttgctcg tgcagcagcc atttacaagt ttgacttgtt gacaggtatg   1200
gttggtgaat ttgacgaact ccaaggaatt atgggtgaaa aatacaccct tcttgctggt   1260
gaaactccag cggtggcagc tgctattcgt gaacactaca tgcctacatc agctgaagga   1320
gaacttccag agagcaaggt cggcgcagtt ctagccattg cagacaaatt ggatacgatt   1380
ttgagtttct tctcagtagg attgattcca tcaggttcta atgaccctta tgcccttcgt   1440
cgtgcaactc aaggtgtggt tcgtatcttg gatgcctttg gttggcacat tgctatggat   1500
gagctgattg atagccttta tgcattgaaa tttgacagtt tgacttatga aaataaagca   1560
gaggttatgg actttatcaa ggctcgtgtt gataagatga tgggctctac tccaaaagat   1620
atcaaggaag cagttcttgc aggttcaaac tttgttgtgg cagatatgtt ggaagcagca   1680
agtgctctcg tagaagtaag caaggaagaa gattttaaac catctgttga atcactttct   1740
cgtgccttta acctggccga gaaggcagaa ggggttgcta cggttgattc agcactattt   1800
gagaatgacc aagaaaaagc tttggcagaa gcagtagaaa cactcatttt atcaggacct   1860
gcaagtcagc aattgaaaca actttttgcg cttagcccag tcattgatgc tttctttgaa   1920
aatactatgg taatggctga agatcaggct gtccgtcaaa atcgtttggc aatcttgtca   1980
caactaacca agaaagcagc taagtttgct tgttttaacc aaattaacac taaa         2034

<210>   3000
<211>   678
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycyl-tRNA synthetase, beta subunit (glyS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903371 (0.E+01)

<400>   3000
Met Thr Lys Asn Leu Leu Val Glu Leu Gly Leu Glu Glu Leu Pro Ala 
1               5                   10                  15      

Tyr Val Val Thr Pro Ser Glu Lys Gln Leu Gly Glu Lys Met Ala Ala 
            20                  25                  30          

Phe Leu Lys Gly Lys Arg Leu Ser Phe Glu Ala Ile Gln Thr Phe Ser 
        35                  40                  45              

Thr Pro Arg Arg Leu Ala Val Arg Val Thr Gly Leu Ala Asp Lys Gln 
    50                  55                  60                  

Ser Asp Leu Thr Glu Asp Phe Lys Gly Pro Ala Lys Lys Ile Ala Leu 
65                  70                  75                  80  

Asp Ser Asp Gly Asn Phe Thr Lys Ala Ala Gln Gly Phe Val Arg Gly 
                85                  90                  95      


Lys Gly Leu Thr Val Glu Asp Ile Glu Phe Arg Glu Ile Lys Gly Glu 
            100                 105                 110         

Glu Tyr Val Tyr Val Thr Lys Glu Glu Ile Gly Gln Ala Val Glu Ala 
        115                 120                 125             

Ile Val Pro Gly Ile Val Asp Val Leu Lys Ser Leu Thr Phe Pro Val 
    130                 135                 140                 

Ser Met His Trp Ala Gly Asn Ser Phe Glu Tyr Ile Arg Pro Val His 
145                 150                 155                 160 

Thr Leu Thr Val Leu Leu Asp Glu Gln Glu Phe Asp Leu Asp Phe Leu 
                165                 170                 175     

Asp Ile Lys Gly Ser Arg Val Ser Arg Gly His Arg Phe Leu Gly Gln 
            180                 185                 190         

Glu Thr Lys Ile Gln Ser Ala Leu Ser Tyr Glu Glu Asp Leu Arg Lys 
        195                 200                 205             

Gln Phe Val Ile Ala Asp Pro Cys Glu Arg Glu Gln Met Ile Val Asp 
    210                 215                 220                 

Gln Ile Lys Glu Ile Glu Ala Lys His Gly Val Arg Ile Glu Ile Asp 
225                 230                 235                 240 

Ala Asp Leu Leu Asn Glu Val Leu Asn Leu Val Glu Tyr Pro Thr Ala 
                245                 250                 255     

Phe Met Gly Ser Phe Asp Ala Lys Tyr Leu Glu Val Pro Glu Glu Val 
            260                 265                 270         

Leu Val Thr Ser Met Lys Glu His Gln Arg Tyr Phe Val Val Arg Asp 
        275                 280                 285             

Gln Asp Gly Lys Leu Leu Pro Asn Phe Ile Ser Val Arg Asn Gly Asn 
    290                 295                 300                 

Ala Glu Arg Leu Lys Asn Val Ile Lys Gly Asn Glu Lys Val Leu Val 
305                 310                 315                 320 

Ala Arg Leu Glu Asp Gly Glu Phe Phe Trp Arg Glu Asp Gln Lys Leu 
                325                 330                 335     

Val Ile Ser Asp Leu Val Glu Lys Leu Asn Asn Val Thr Phe His Glu 
            340                 345                 350         

Lys Ile Gly Ser Leu Arg Glu His Met Ile Arg Thr Gly Gln Ile Thr 
        355                 360                 365             

Val Leu Leu Ala Glu Lys Ala Ser Leu Ser Val Asp Glu Thr Val Asp 
    370                 375                 380                 

Leu Ala Arg Ala Ala Ala Ile Tyr Lys Phe Asp Leu Leu Thr Gly Met 
385                 390                 395                 400 

Val Gly Glu Phe Asp Glu Leu Gln Gly Ile Met Gly Glu Lys Tyr Thr 
                405                 410                 415     

Leu Leu Ala Gly Glu Thr Pro Ala Val Ala Ala Ala Ile Arg Glu His 
            420                 425                 430         


Tyr Met Pro Thr Ser Ala Glu Gly Glu Leu Pro Glu Ser Lys Val Gly 
        435                 440                 445             

Ala Val Leu Ala Ile Ala Asp Lys Leu Asp Thr Ile Leu Ser Phe Phe 
    450                 455                 460                 

Ser Val Gly Leu Ile Pro Ser Gly Ser Asn Asp Pro Tyr Ala Leu Arg 
465                 470                 475                 480 

Arg Ala Thr Gln Gly Val Val Arg Ile Leu Asp Ala Phe Gly Trp His 
                485                 490                 495     

Ile Ala Met Asp Glu Leu Ile Asp Ser Leu Tyr Ala Leu Lys Phe Asp 
            500                 505                 510         

Ser Leu Thr Tyr Glu Asn Lys Ala Glu Val Met Asp Phe Ile Lys Ala 
        515                 520                 525             

Arg Val Asp Lys Met Met Gly Ser Thr Pro Lys Asp Ile Lys Glu Ala 
    530                 535                 540                 

Val Leu Ala Gly Ser Asn Phe Val Val Ala Asp Met Leu Glu Ala Ala 
545                 550                 555                 560 

Ser Ala Leu Val Glu Val Ser Lys Glu Glu Asp Phe Lys Pro Ser Val 
                565                 570                 575     

Glu Ser Leu Ser Arg Ala Phe Asn Leu Ala Glu Lys Ala Glu Gly Val 
            580                 585                 590         

Ala Thr Val Asp Ser Ala Leu Phe Glu Asn Asp Gln Glu Lys Ala Leu 
        595                 600                 605             

Ala Glu Ala Val Glu Thr Leu Ile Leu Ser Gly Pro Ala Ser Gln Gln 
    610                 615                 620                 

Leu Lys Gln Leu Phe Ala Leu Ser Pro Val Ile Asp Ala Phe Phe Glu 
625                 630                 635                 640 

Asn Thr Met Val Met Ala Glu Asp Gln Ala Val Arg Gln Asn Arg Leu 
                645                 650                 655     

Ala Ile Leu Ser Gln Leu Thr Lys Lys Ala Ala Lys Phe Ala Cys Phe 
            660                 665                 670         

Asn Gln Ile Asn Thr Lys 
        675             

<210>   3001
<211>   915
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3001
atgtctaaga aattaacatt tcaagaaatt attttgactt tgcaacaatt ttggaatgac   60
caagattgta tgcttatgca ggcttatgat aatgaaaaag gtgcggggac aatgagtcct   120
tacactttcc ttcgtgctat cggacctgag ccatggaatg cagcttatgt agagccatca   180
cgtcgtcctg ctgacggtcg ttatggggaa aaccctaacc gtctctacca acaccaccaa   240
ttccaggtgg tcatgaagcc ttctccatca aatatccaag aactttacct tgagtctttg   300
gaaaaattgg gaatcaatcc tttggagcac gatattcgtt ttgttgagga caactgggaa   360
aacccatcaa ctggttcagc tggtcttggt tgggaagttt ggcttgacgg aatggaaatc   420
actcagttca cttatttcca acaagtcggt ggattggcaa ctggccctgt gactgcggaa   480
gttacctatg gtttggagcg cttggcttct tacattcaag aagtagactc tgtctatgat   540
atcgagtggg ctgatggtgt aaaatacgga gaaatcttta tccagcctga gtatgagcac   600
tcaaaatatt catttgaaat ttcggaccaa gaaatgttgc ttgaaaactt tgataagttt   660
gaaaaagaag ctggtcgtgc attagaagaa ggcttggtac accctgccta tgactatgtt   720
ctcaaatgtt cacatacctt taatctgctt gacgcgcgtg gtgccgtatc tgtaacagag   780
cgtgcaggct atatcgctcg tatccgtaac ttggcccgtg tcgtagccaa aacctttgtc   840
gcagaacgca aacgcctagg ctacccactt ttggatgaag aaacaagagc taaactccta   900
gcagaagacg cagaa                                                    915

<210>   3002
<211>   305
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycyl-tRNA synthetase, alpha subunit (glyQ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903372 (e-179)

<400>   3002
Met Ser Lys Lys Leu Thr Phe Gln Glu Ile Ile Leu Thr Leu Gln Gln 
1               5                   10                  15      

Phe Trp Asn Asp Gln Asp Cys Met Leu Met Gln Ala Tyr Asp Asn Glu 
            20                  25                  30          

Lys Gly Ala Gly Thr Met Ser Pro Tyr Thr Phe Leu Arg Ala Ile Gly 
        35                  40                  45              

Pro Glu Pro Trp Asn Ala Ala Tyr Val Glu Pro Ser Arg Arg Pro Ala 
    50                  55                  60                  

Asp Gly Arg Tyr Gly Glu Asn Pro Asn Arg Leu Tyr Gln His His Gln 
65                  70                  75                  80  

Phe Gln Val Val Met Lys Pro Ser Pro Ser Asn Ile Gln Glu Leu Tyr 
                85                  90                  95      

Leu Glu Ser Leu Glu Lys Leu Gly Ile Asn Pro Leu Glu His Asp Ile 
            100                 105                 110         

Arg Phe Val Glu Asp Asn Trp Glu Asn Pro Ser Thr Gly Ser Ala Gly 
        115                 120                 125             

Leu Gly Trp Glu Val Trp Leu Asp Gly Met Glu Ile Thr Gln Phe Thr 
    130                 135                 140                 

Tyr Phe Gln Gln Val Gly Gly Leu Ala Thr Gly Pro Val Thr Ala Glu 
145                 150                 155                 160 

Val Thr Tyr Gly Leu Glu Arg Leu Ala Ser Tyr Ile Gln Glu Val Asp 
                165                 170                 175     

Ser Val Tyr Asp Ile Glu Trp Ala Asp Gly Val Lys Tyr Gly Glu Ile 
            180                 185                 190         

Phe Ile Gln Pro Glu Tyr Glu His Ser Lys Tyr Ser Phe Glu Ile Ser 
        195                 200                 205             

Asp Gln Glu Met Leu Leu Glu Asn Phe Asp Lys Phe Glu Lys Glu Ala 
    210                 215                 220                 

Gly Arg Ala Leu Glu Glu Gly Leu Val His Pro Ala Tyr Asp Tyr Val 
225                 230                 235                 240 

Leu Lys Cys Ser His Thr Phe Asn Leu Leu Asp Ala Arg Gly Ala Val 
                245                 250                 255     

Ser Val Thr Glu Arg Ala Gly Tyr Ile Ala Arg Ile Arg Asn Leu Ala 
            260                 265                 270         

Arg Val Val Ala Lys Thr Phe Val Ala Glu Arg Lys Arg Leu Gly Tyr 
        275                 280                 285             


Pro Leu Leu Asp Glu Glu Thr Arg Ala Lys Leu Leu Ala Glu Asp Ala 
    290                 295                 300                 

Glu 
305 

<210>   3003
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3003
ttggtcggac attttttaga tgattttgat ggttatgact cttatatctg gttcgaagag   60
gggatggttg aatatattag tcgcaagtat ttcttgacag aagaggaatt tcaagcggaa   120
aaaatttgta atcaatctct cgtagaactt tttcagaaga agtatagttg gcattcattg   180
aatgattttg gttcttcgac ttatgataag aactatgcaa gtatttttta tgaatactgg   240
cgcagctttt tgacagtaga taagttggta gaaaatttag gtagtgtaca agcggtctta   300
gattcttatc atttatgggc aaatacagaa aaaacttttc ccttgttaga ttggtttgtt   360
cagcagaaat taattgaaaa agaaata                                       387

<210>   3004
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903373 (4.E-74)

<400>   3004
Met Val Gly His Phe Leu Asp Asp Phe Asp Gly Tyr Asp Ser Tyr Ile 
1               5                   10                  15      

Trp Phe Glu Glu Gly Met Val Glu Tyr Ile Ser Arg Lys Tyr Phe Leu 
            20                  25                  30          

Thr Glu Glu Glu Phe Gln Ala Glu Lys Ile Cys Asn Gln Ser Leu Val 
        35                  40                  45              

Glu Leu Phe Gln Lys Lys Tyr Ser Trp His Ser Leu Asn Asp Phe Gly 
    50                  55                  60                  

Ser Ser Thr Tyr Asp Lys Asn Tyr Ala Ser Ile Phe Tyr Glu Tyr Trp 
65                  70                  75                  80  

Arg Ser Phe Leu Thr Val Asp Lys Leu Val Glu Asn Leu Gly Ser Val 
                85                  90                  95      

Gln Ala Val Leu Asp Ser Tyr His Leu Trp Ala Asn Thr Glu Lys Thr 
            100                 105                 110         

Phe Pro Leu Leu Asp Trp Phe Val Gln Gln Lys Leu Ile Glu Lys Glu 
        115                 120                 125             

Ile 
    

<210>   3005
<211>   405
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3005
gtgaaagaaa ggagagccgt ggacaacctt tatcttgtaa aagacgatag tcaactagct   60
acatttcgtg attttgtagt aagaaatact gaaaagttga aagattatca atctttttta   120
aagaatgaac ttgcagtctg tgatttaccg caagctgtta tttggtcaga ttttaatgct   180
gctacacaga ttattaggga aagtgctgtt ccaacctata caaataatag acgagtggtt   240
atgacgcctg atttagctgt ttggaaagaa ttgtatttgt atcagttgat ggactacgag   300
tgttctgagc aaactcaagc aatagaaagt cactatcatt ctttatctga aaatttcctc   360
ttacagattg taggacatga gttagctcat tggtcggaca ttttt                   405

<210>   3006
<211>   135
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903374 (3.E-76)

<400>   3006
Met Lys Glu Arg Arg Ala Val Asp Asn Leu Tyr Leu Val Lys Asp Asp 
1               5                   10                  15      

Ser Gln Leu Ala Thr Phe Arg Asp Phe Val Val Arg Asn Thr Glu Lys 
            20                  25                  30          

Leu Lys Asp Tyr Gln Ser Phe Leu Lys Asn Glu Leu Ala Val Cys Asp 
        35                  40                  45              

Leu Pro Gln Ala Val Ile Trp Ser Asp Phe Asn Ala Ala Thr Gln Ile 
    50                  55                  60                  

Ile Arg Glu Ser Ala Val Pro Thr Tyr Thr Asn Asn Arg Arg Val Val 
65                  70                  75                  80  

Met Thr Pro Asp Leu Ala Val Trp Lys Glu Leu Tyr Leu Tyr Gln Leu 
                85                  90                  95      

Met Asp Tyr Glu Cys Ser Glu Gln Thr Gln Ala Ile Glu Ser His Tyr 
            100                 105                 110         

His Ser Leu Ser Glu Asn Phe Leu Leu Gln Ile Val Gly His Glu Leu 
        115                 120                 125             

Ala His Trp Ser Asp Ile Phe 
    130                 135 

<210>   3007
<211>   840
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3007
atgaatacct atcaattaaa taatggagta gaaattccag tattgggatt tggaactttt   60
aaggctaagg atggagaaga agcctatcgt gcagtgttag aagccttgaa ggctggttat   120
cgtcatattg atacggcggc gatttatcag aatgaagaaa gtgttggtca agcaatcaaa   180
gatagcggag ttccacgtga agaaatgttc gtaactacca agctttggaa tagtcagcaa   240
acctatgagc aaactcgtca agctttggaa aaatctatag aaaaactggg cttggattat   300
ttggatttgt atttgattca ttggccgaac ccaaaaccgc tcagagaaaa tgacgcatgg   360
aaaactcgca atgcggaagt ttggagagcg atggaagacc tctatcaaga agggaaaatc   420
cgtgctatcg gcgttagcaa ttttcttccc catcatttgg atgccttgct tgaaactgca   480
actatcgttc ctgcggtcaa tcaagttcgc ttggcgccag gtgtgtatca agatcaagtc   540
gtagcttact gtcgtgaaaa gggaatttta ttggaagctt gggggccttt tggacaagga   600
gaactgtttg atagcaagca agtccaagaa atagcagcaa atcacggaaa atcggttgct   660
cagatagcct tggcctggag cttggcagaa ggatttttac cacttccaaa atctgtcaca   720
acctctcgta ttcaagctaa tcttgattgc tttggaattg aactgagtca tgaggagaga   780
gaaaccttaa aaacgattgc tgttcaatcg ggtgctccac gagttgatga tgtggatttc   840

<210>   3008
<211>   280
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, aldo/keto reductase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903375 (e-163)

<400>   3008
Met Asn Thr Tyr Gln Leu Asn Asn Gly Val Glu Ile Pro Val Leu Gly 
1               5                   10                  15      

Phe Gly Thr Phe Lys Ala Lys Asp Gly Glu Glu Ala Tyr Arg Ala Val 
            20                  25                  30          

Leu Glu Ala Leu Lys Ala Gly Tyr Arg His Ile Asp Thr Ala Ala Ile 
        35                  40                  45              

Tyr Gln Asn Glu Glu Ser Val Gly Gln Ala Ile Lys Asp Ser Gly Val 
    50                  55                  60                  

Pro Arg Glu Glu Met Phe Val Thr Thr Lys Leu Trp Asn Ser Gln Gln 
65                  70                  75                  80  

Thr Tyr Glu Gln Thr Arg Gln Ala Leu Glu Lys Ser Ile Glu Lys Leu 
                85                  90                  95      

Gly Leu Asp Tyr Leu Asp Leu Tyr Leu Ile His Trp Pro Asn Pro Lys 
            100                 105                 110         

Pro Leu Arg Glu Asn Asp Ala Trp Lys Thr Arg Asn Ala Glu Val Trp 
        115                 120                 125             

Arg Ala Met Glu Asp Leu Tyr Gln Glu Gly Lys Ile Arg Ala Ile Gly 
    130                 135                 140                 

Val Ser Asn Phe Leu Pro His His Leu Asp Ala Leu Leu Glu Thr Ala 
145                 150                 155                 160 

Thr Ile Val Pro Ala Val Asn Gln Val Arg Leu Ala Pro Gly Val Tyr 
                165                 170                 175     

Gln Asp Gln Val Val Ala Tyr Cys Arg Glu Lys Gly Ile Leu Leu Glu 
            180                 185                 190         

Ala Trp Gly Pro Phe Gly Gln Gly Glu Leu Phe Asp Ser Lys Gln Val 
        195                 200                 205             

Gln Glu Ile Ala Ala Asn His Gly Lys Ser Val Ala Gln Ile Ala Leu 
    210                 215                 220                 

Ala Trp Ser Leu Ala Glu Gly Phe Leu Pro Leu Pro Lys Ser Val Thr 
225                 230                 235                 240 

Thr Ser Arg Ile Gln Ala Asn Leu Asp Cys Phe Gly Ile Glu Leu Ser 
                245                 250                 255     

His Glu Glu Arg Glu Thr Leu Lys Thr Ile Ala Val Gln Ser Gly Ala 
            260                 265                 270         

Pro Arg Val Asp Asp Val Asp Phe 
        275                 280 

<210>   3009
<211>   1440
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3009
ttgccaaatt gtatcattga aattattgct caaatttgtt atgatataaa tatgaataaa   60
agtagactag gacgtggcag acacgggaaa acgagacatg tattattggc tttgattggt   120
attttagcaa tttctatttg cctattaggc ggatttattg cttttaagat ctaccagcaa   180
aaaagttttg agcaaaagat tgaatcgctc aaaaaagaga aagatgatca attgagtgag   240
ggaaatcaga aggagcattt tcgtcagggg caagccgaag tgattgccta ttatcctctc   300
caaggggaga aagtgatttc ctctgttagg gagctgataa atcaagatgt taaggacaag   360
ctagaaagta aggacaatct tgttttctac tatacagagc aagaagagtc aggtttaaag   420
ggagtcgtta atcgtaatgt gaccaaacaa atctatgatt tagttgcttt taagattgaa   480
gagactgaaa agaccagtct aggaaaggtt cacttaacag aagatgggca accttttaca   540
cttgaccaac tgttttcaga tgctagtaag gctaaggaac agctgataaa agagttgacc   600
tccttcatag aggataaaaa aatagagcaa gaccagagtg agcagattgt aaaaaacttc   660
tctgaccaag acttgtctgc atggaatttt gattacaagg atagtcagat tatcctttat   720
ccaagtcctg tggttgaaaa tttagaagag atagccttgc cagtatctgc tttctttgat   780
gttatccaat cttcgtactt actcgaaaaa gatgcggcct tgtaccaatc ttactttgat   840
aagaaacatc aaaaagttgt cgctctaacc tttgatgatg gtccaaatcc agcaacgacc   900
ccgcaggtat tagagaccct agctaaatat gatattaaag cgactttctt tgtgcttggg   960
aaaaatgttt ctgggaatga ggacttggtg aagaggataa aatctgaagg tcatgttgtt   1020
ggaaaccata gctggagcca tccgattctc tcgcaactct ctcttgatga agctaaaaag   1080
cagattactg atactgagga tgtgctaact aaagtgctgg gttctagttc taaactcatg   1140
cgtccacctt atggtgctat tacagatgat attcgcaata gcttggattt gagctttatc   1200
atgtgggatg tggatagtct ggactggaag agtaaaaatg aagcatctat tttgacagaa   1260
attcagtatc aagtagctaa tggctctatc gttttgatgc atgatattca cagtccgaca   1320
gtcaatgcct tgccaagggt cattgagtat ttgaaaaatc aaggttatac ctttgtgacc   1380
ataccagaga tgctcaatac tcgcctaaaa gctcatgagc tgtactatag tcgtgatgaa   1440

<210>   3010
<211>   480
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidoglycan N-acetylglucosamine deacetylase A (pgdA)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903376 (0.E+01)

<400>   3010
Met Pro Asn Cys Ile Ile Glu Ile Ile Ala Gln Ile Cys Tyr Asp Ile 
1               5                   10                  15      

Asn Met Asn Lys Ser Arg Leu Gly Arg Gly Arg His Gly Lys Thr Arg 
            20                  25                  30          

His Val Leu Leu Ala Leu Ile Gly Ile Leu Ala Ile Ser Ile Cys Leu 
        35                  40                  45              

Leu Gly Gly Phe Ile Ala Phe Lys Ile Tyr Gln Gln Lys Ser Phe Glu 
    50                  55                  60                  

Gln Lys Ile Glu Ser Leu Lys Lys Glu Lys Asp Asp Gln Leu Ser Glu 
65                  70                  75                  80  

Gly Asn Gln Lys Glu His Phe Arg Gln Gly Gln Ala Glu Val Ile Ala 
                85                  90                  95      

Tyr Tyr Pro Leu Gln Gly Glu Lys Val Ile Ser Ser Val Arg Glu Leu 
            100                 105                 110         

Ile Asn Gln Asp Val Lys Asp Lys Leu Glu Ser Lys Asp Asn Leu Val 
        115                 120                 125             

Phe Tyr Tyr Thr Glu Gln Glu Glu Ser Gly Leu Lys Gly Val Val Asn 
    130                 135                 140                 

Arg Asn Val Thr Lys Gln Ile Tyr Asp Leu Val Ala Phe Lys Ile Glu 
145                 150                 155                 160 

Glu Thr Glu Lys Thr Ser Leu Gly Lys Val His Leu Thr Glu Asp Gly 
                165                 170                 175     

Gln Pro Phe Thr Leu Asp Gln Leu Phe Ser Asp Ala Ser Lys Ala Lys 
            180                 185                 190         

Glu Gln Leu Ile Lys Glu Leu Thr Ser Phe Ile Glu Asp Lys Lys Ile 
        195                 200                 205             

Glu Gln Asp Gln Ser Glu Gln Ile Val Lys Asn Phe Ser Asp Gln Asp 
    210                 215                 220                 

Leu Ser Ala Trp Asn Phe Asp Tyr Lys Asp Ser Gln Ile Ile Leu Tyr 
225                 230                 235                 240 

Pro Ser Pro Val Val Glu Asn Leu Glu Glu Ile Ala Leu Pro Val Ser 
                245                 250                 255     

Ala Phe Phe Asp Val Ile Gln Ser Ser Tyr Leu Leu Glu Lys Asp Ala 
            260                 265                 270         

Ala Leu Tyr Gln Ser Tyr Phe Asp Lys Lys His Gln Lys Val Val Ala 
        275                 280                 285             

Leu Thr Phe Asp Asp Gly Pro Asn Pro Ala Thr Thr Pro Gln Val Leu 
    290                 295                 300                 

Glu Thr Leu Ala Lys Tyr Asp Ile Lys Ala Thr Phe Phe Val Leu Gly 
305                 310                 315                 320 

Lys Asn Val Ser Gly Asn Glu Asp Leu Val Lys Arg Ile Lys Ser Glu 
                325                 330                 335     

Gly His Val Val Gly Asn His Ser Trp Ser His Pro Ile Leu Ser Gln 
            340                 345                 350         

Leu Ser Leu Asp Glu Ala Lys Lys Gln Ile Thr Asp Thr Glu Asp Val 
        355                 360                 365             

Leu Thr Lys Val Leu Gly Ser Ser Ser Lys Leu Met Arg Pro Pro Tyr 
    370                 375                 380                 

Gly Ala Ile Thr Asp Asp Ile Arg Asn Ser Leu Asp Leu Ser Phe Ile 
385                 390                 395                 400 

Met Trp Asp Val Asp Ser Leu Asp Trp Lys Ser Lys Asn Glu Ala Ser 
                405                 410                 415     

Ile Leu Thr Glu Ile Gln Tyr Gln Val Ala Asn Gly Ser Ile Val Leu 
            420                 425                 430         

Met His Asp Ile His Ser Pro Thr Val Asn Ala Leu Pro Arg Val Ile 
        435                 440                 445             

Glu Tyr Leu Lys Asn Gln Gly Tyr Thr Phe Val Thr Ile Pro Glu Met 
    450                 455                 460                 

Leu Asn Thr Arg Leu Lys Ala His Glu Leu Tyr Tyr Ser Arg Asp Glu 
465                 470                 475                 480 


<210>   3011
<211>   243
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3011
ttggcggagt tagataatgg aatccaagtt atcatcgaaa ttcaggttca tcatcagaat   60
tttttcatca atcgcctatg gccttatctg tgcagtcagg ttaatcaaaa cctagaaaaa   120
attcgccaac gtgaaggtga tacccaccag agctacaaac aaatcgcact agtatacgct   180
atcgcaattg tcgatagtaa ttacttctca gatgacctag cttttcatag ttttatagta   240
aaa                                                                 243

<210>   3012
<211>   81
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903377 (8.E-44)

<400>   3012
Met Ala Glu Leu Asp Asn Gly Ile Gln Val Ile Ile Glu Ile Gln Val 
1               5                   10                  15      

His His Gln Asn Phe Phe Ile Asn Arg Leu Trp Pro Tyr Leu Cys Ser 
            20                  25                  30          

Gln Val Asn Gln Asn Leu Glu Lys Ile Arg Gln Arg Glu Gly Asp Thr 
        35                  40                  45              

His Gln Ser Tyr Lys Gln Ile Ala Leu Val Tyr Ala Ile Ala Ile Val 
    50                  55                  60                  

Asp Ser Asn Tyr Phe Ser Asp Asp Leu Ala Phe His Ser Phe Ile Val 
65                  70                  75                  80  

Lys 
    

<210>   3013
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3013
atgatttgtc aatttatccg cgatatgctg gacttgccag caaaaaatgt gacgattttg   60
gagggaagta acattcacgt cttgccttcc atgccctact cagcg                   105

<210>   3014
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902075 (1.E-12)

<400>   3014
Met Ile Cys Gln Phe Ile Arg Asp Met Leu Asp Leu Pro Ala Lys Asn 
1               5                   10                  15      

Val Thr Ile Leu Glu Gly Ser Asn Ile His Val Leu Pro Ser Met Pro 
            20                  25                  30          

Tyr Ser Ala 
        35  

<210>   3015
<211>   1059
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3015
ttgaaatttt ctcctctctg ttggatagtc ccgtctatct atgttataat gaaagaagga   60
tttaaaatcg gaaaaggagt atttatgcta aaattaggtg tcatcggaac tggcgctatc   120
agccatcatt tcatagaagc agcccatacc agtggagaat accaactggt cgcaatctat   180
tctagaaaac tagaaactgc agcaaccttt gcttctcgct atcagaatat ccaactattc   240
gatcaattag aagtcttctt caaatcttct tttgatttag tctatatcgc cagtccaaac   300
tccttacatt ttgctcaggc aaaagctgcc ttgtctgctg gtaaacatgt tattctcgaa   360
aagccagctg tctctcaacc acaagaatgg tttgatttga ttcaaacagc tgaaaaaaat   420
aactgtttta tctttgaagc agctcgtaat taccacgaga aagcctttac tactatcaaa   480
aactttttag cagataagca agtgttagga gcagatttca actatgccaa atactcttcc   540
aagatgcctg acttgttggc tggacaaaca ccaaatgtct tttcagaccg ttttgctggt   600
ggagccctca tggatttggg gatttatccc ctctatgctg ctgttcgtct ttttggaaaa   660
gccaatgacg cgacttacca tgctcaacag cttgacaata gcattgacct aaatggagat   720
ggtatcctct tctacccaga ctatcaagtt cacatcaagg ctggaaaaaa catcacttcc   780
aatcttcctt gcgagattta tacaacagat ggaaccttga ctctcaacac gattgagcat   840
attcgctcag ctatttttac cgaccaccaa ggaaatcaag tccagcttcc tatccaacag   900
gctcctcata cgatgactga ggaagtcgct gcatttgcac acatgatcca gcaaccagat   960
ctgaatctct accaaacttg gctgtatgat gcaggctctg ttcatgagct actatatacc   1020
atgcgccaga ctgctggcat tagatttgag gcagaaaaa                          1059

<210>   3016
<211>   353
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, Gfo/Idh/MocA family
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903378 (0.E+01)

<400>   3016
Met Lys Phe Ser Pro Leu Cys Trp Ile Val Pro Ser Ile Tyr Val Ile 
1               5                   10                  15      

Met Lys Glu Gly Phe Lys Ile Gly Lys Gly Val Phe Met Leu Lys Leu 
            20                  25                  30          

Gly Val Ile Gly Thr Gly Ala Ile Ser His His Phe Ile Glu Ala Ala 
        35                  40                  45              

His Thr Ser Gly Glu Tyr Gln Leu Val Ala Ile Tyr Ser Arg Lys Leu 
    50                  55                  60                  

Glu Thr Ala Ala Thr Phe Ala Ser Arg Tyr Gln Asn Ile Gln Leu Phe 
65                  70                  75                  80  

Asp Gln Leu Glu Val Phe Phe Lys Ser Ser Phe Asp Leu Val Tyr Ile 
                85                  90                  95      

Ala Ser Pro Asn Ser Leu His Phe Ala Gln Ala Lys Ala Ala Leu Ser 
            100                 105                 110         

Ala Gly Lys His Val Ile Leu Glu Lys Pro Ala Val Ser Gln Pro Gln 
        115                 120                 125             

Glu Trp Phe Asp Leu Ile Gln Thr Ala Glu Lys Asn Asn Cys Phe Ile 
    130                 135                 140                 

Phe Glu Ala Ala Arg Asn Tyr His Glu Lys Ala Phe Thr Thr Ile Lys 
145                 150                 155                 160 

Asn Phe Leu Ala Asp Lys Gln Val Leu Gly Ala Asp Phe Asn Tyr Ala 
                165                 170                 175     

Lys Tyr Ser Ser Lys Met Pro Asp Leu Leu Ala Gly Gln Thr Pro Asn 
            180                 185                 190         

Val Phe Ser Asp Arg Phe Ala Gly Gly Ala Leu Met Asp Leu Gly Ile 
        195                 200                 205             

Tyr Pro Leu Tyr Ala Ala Val Arg Leu Phe Gly Lys Ala Asn Asp Ala 
    210                 215                 220                 

Thr Tyr His Ala Gln Gln Leu Asp Asn Ser Ile Asp Leu Asn Gly Asp 
225                 230                 235                 240 

Gly Ile Leu Phe Tyr Pro Asp Tyr Gln Val His Ile Lys Ala Gly Lys 
                245                 250                 255     

Asn Ile Thr Ser Asn Leu Pro Cys Glu Ile Tyr Thr Thr Asp Gly Thr 
            260                 265                 270         

Leu Thr Leu Asn Thr Ile Glu His Ile Arg Ser Ala Ile Phe Thr Asp 
        275                 280                 285             

His Gln Gly Asn Gln Val Gln Leu Pro Ile Gln Gln Ala Pro His Thr 
    290                 295                 300                 

Met Thr Glu Glu Val Ala Ala Phe Ala His Met Ile Gln Gln Pro Asp 
305                 310                 315                 320 

Leu Asn Leu Tyr Gln Thr Trp Leu Tyr Asp Ala Gly Ser Val His Glu 
                325                 330                 335     

Leu Leu Tyr Thr Met Arg Gln Thr Ala Gly Ile Arg Phe Glu Ala Glu 
            340                 345                 350         

Lys 
    

<210>   3017
<211>   1080
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3017
atgaaaacca aactaccgac tgaatggcaa gaactgagtg accaactcgg tttccaagaa   60
ttcaccccca ttcaaactca actatttgag ccccttcttg ctggagaaaa cctcctagga   120
gtgagccaaa ccggaactgg taagacccta gcgtatctcc taccaagtct tctcagacta   180
caaaagaaaa aagcccaaca actcttgatt ctagcaccaa atacggaact tgctggacag   240
atttttgatg tatgtaaaac gtgggcagaa gctatcggat tgactgctca actcttcctt   300
tcaggttcaa gtcagaaacg acaaattgaa cgtcttaaaa aggggccaga aattctgatt   360
ggaactcctg gccgtatctt tgaactcatt aaacttaaaa aaatcaagat gatgaatgtg   420
gaaaccatca tcctggatga atttgaccaa ttactagatg attctcagat tcactttgta   480
gaaaaaatca ctcactacgc acctcgtgac caccaactgg tctacatgag tgccacgacc   540
aagtttgacc aagaaaagat tgtgccgaat acacgcacta ttgatctctc tgatcaaaaa   600
ttggacaata tccagcattt ctacatgcag gtagaccaac gtcatcgagt ggatatgcta   660
cgaaaactgg ctcatgtaga ggatttccgt ggtctagtct tcttcaatag cctgtcagac   720
cttgggaatg ccgaggaaaa actacagtat cgtgatatat tggctgtttc cctcgctagt   780
gatgttaatg ttaaatttag aaaaatcatc ttagaaaagt ttaaagataa ccaactaacc   840
ctgcttcttg caactgacct tttggctcgt ggaattgata tcgatagcct agaatgtgtc   900
gtaaactttg atattcctag agatagcgaa acctacacac accgtgctgg ccgtactggt   960
cgtatgggca aggaaggtta tgttatcact ctcgtcactc atccagaaga aatcaaaaaa   1020
cttaaaaagt ttgcaagtat ccgagaaatt gtcctaaaaa accaagaact ctatatcaaa   1080

<210>   3018
<211>   360
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent RNA helicase, DEAD/DEAH box family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903379 (0.E+01)

<400>   3018
Met Lys Thr Lys Leu Pro Thr Glu Trp Gln Glu Leu Ser Asp Gln Leu 
1               5                   10                  15      

Gly Phe Gln Glu Phe Thr Pro Ile Gln Thr Gln Leu Phe Glu Pro Leu 
            20                  25                  30          

Leu Ala Gly Glu Asn Leu Leu Gly Val Ser Gln Thr Gly Thr Gly Lys 
        35                  40                  45              

Thr Leu Ala Tyr Leu Leu Pro Ser Leu Leu Arg Leu Gln Lys Lys Lys 
    50                  55                  60                  

Ala Gln Gln Leu Leu Ile Leu Ala Pro Asn Thr Glu Leu Ala Gly Gln 
65                  70                  75                  80  

Ile Phe Asp Val Cys Lys Thr Trp Ala Glu Ala Ile Gly Leu Thr Ala 
                85                  90                  95      

Gln Leu Phe Leu Ser Gly Ser Ser Gln Lys Arg Gln Ile Glu Arg Leu 
            100                 105                 110         

Lys Lys Gly Pro Glu Ile Leu Ile Gly Thr Pro Gly Arg Ile Phe Glu 
        115                 120                 125             

Leu Ile Lys Leu Lys Lys Ile Lys Met Met Asn Val Glu Thr Ile Ile 
    130                 135                 140                 

Leu Asp Glu Phe Asp Gln Leu Leu Asp Asp Ser Gln Ile His Phe Val 
145                 150                 155                 160 

Glu Lys Ile Thr His Tyr Ala Pro Arg Asp His Gln Leu Val Tyr Met 
                165                 170                 175     

Ser Ala Thr Thr Lys Phe Asp Gln Glu Lys Ile Val Pro Asn Thr Arg 
            180                 185                 190         

Thr Ile Asp Leu Ser Asp Gln Lys Leu Asp Asn Ile Gln His Phe Tyr 
        195                 200                 205             

Met Gln Val Asp Gln Arg His Arg Val Asp Met Leu Arg Lys Leu Ala 
    210                 215                 220                 

His Val Glu Asp Phe Arg Gly Leu Val Phe Phe Asn Ser Leu Ser Asp 
225                 230                 235                 240 

Leu Gly Asn Ala Glu Glu Lys Leu Gln Tyr Arg Asp Ile Leu Ala Val 
                245                 250                 255     

Ser Leu Ala Ser Asp Val Asn Val Lys Phe Arg Lys Ile Ile Leu Glu 
            260                 265                 270         

Lys Phe Lys Asp Asn Gln Leu Thr Leu Leu Leu Ala Thr Asp Leu Leu 
        275                 280                 285             

Ala Arg Gly Ile Asp Ile Asp Ser Leu Glu Cys Val Val Asn Phe Asp 
    290                 295                 300                 

Ile Pro Arg Asp Ser Glu Thr Tyr Thr His Arg Ala Gly Arg Thr Gly 
305                 310                 315                 320 

Arg Met Gly Lys Glu Gly Tyr Val Ile Thr Leu Val Thr His Pro Glu 
                325                 330                 335     

Glu Ile Lys Lys Leu Lys Lys Phe Ala Ser Ile Arg Glu Ile Val Leu 
            340                 345                 350         

Lys Asn Gln Glu Leu Tyr Ile Lys 
        355                 360 

<210>   3019
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3019
gtgtggaaag agattcgtaa acgtggattt aagaataaag cctttcgaac tttggaagat   60
gtcatgaatc aactccaaga tgtcatacaa ggattggaga aggaggtgat aaagtccatc   120
gttaatcgga gatggactag aatgcttttt gaaaacaga                          159

<210>   3020
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3020
Met Trp Lys Glu Ile Arg Lys Arg Gly Phe Lys Asn Lys Ala Phe Arg 
1               5                   10                  15      

Thr Leu Glu Asp Val Met Asn Gln Leu Gln Asp Val Ile Gln Gly Leu 
            20                  25                  30          

Glu Lys Glu Val Ile Lys Ser Ile Val Asn Arg Arg Trp Thr Arg Met 
        35                  40                  45              

Leu Phe Glu Asn Arg 
    50              

<210>   3021
<211>   414
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3021
ttgatgtacc aagatgaggc tggtttcggt agaatcagta aactgggatc ttgttggtct   60
ccaataggag taggtccaca tgtccatagt cactatatac gagaatttcg ctattgttat   120
ggagctgttg atgcccatac aggcgaatca tttttcttaa tagctggtgg atgtaatact   180
gagtggatga acgccttttt agaagagctt tcacaagctt atccagatga ttatctttta   240
ctcgttatgg acaatgctat atggcataaa tcaagtacct taaagattcc gactaatatt   300
ggttttacct ttattcctcc atacacacca gagatgaacc cattgaacaa gtgtggaaag   360
agattcgtaa acgtggattt aagaataaag cctttcgaac tttggaagat gtca         414

<210>   3022
<211>   138
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase family protein, FRAMESHIFT

<400>   3022
Met Met Tyr Gln Asp Glu Ala Gly Phe Gly Arg Ile Ser Lys Leu Gly 
1               5                   10                  15      

Ser Cys Trp Ser Pro Ile Gly Val Gly Pro His Val His Ser His Tyr 
            20                  25                  30          

Ile Arg Glu Phe Arg Tyr Cys Tyr Gly Ala Val Asp Ala His Thr Gly 
        35                  40                  45              

Glu Ser Phe Phe Leu Ile Ala Gly Gly Cys Asn Thr Glu Trp Met Asn 
    50                  55                  60                  

Ala Phe Leu Glu Glu Leu Ser Gln Ala Tyr Pro Asp Asp Tyr Leu Leu 
65                  70                  75                  80  

Leu Val Met Asp Asn Ala Ile Trp His Lys Ser Ser Thr Leu Lys Ile 
                85                  90                  95      

Pro Thr Asn Ile Gly Phe Thr Phe Ile Pro Pro Tyr Thr Pro Glu Met 
            100                 105                 110         

Asn Pro Leu Asn Lys Cys Gly Lys Arg Phe Val Asn Val Asp Leu Arg 
        115                 120                 125             

Ile Lys Pro Phe Glu Leu Trp Lys Met Ser 
    130                 135             

<210>   3023
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3023
ttgttgagaa aacaagaggg agagtacctg agagcggaga atgccatcct aaaaaagtta   60
agagaactcc gattgaagga ggaaaaagag aaagaagaaa gacagaaatt attcaagaat   120

<210>   3024
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3024
Met Leu Arg Lys Gln Glu Gly Glu Tyr Leu Arg Ala Glu Asn Ala Ile 
1               5                   10                  15      

Leu Lys Lys Leu Arg Glu Leu Arg Leu Lys Glu Glu Lys Glu Lys Glu 
            20                  25                  30          

Glu Arg Gln Lys Leu Phe Lys Asn 
        35                  40  

<210>   3025
<211>   831
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3025
atgactgagt tttcgttaga tattcttcta aaagccatta aactagctcg tttgacctac   60
tactatcact tgaaacagct agataaacca gataaggacc aagagcttaa agctgaaatt   120
caatccattt ttatcgaaca caagggaaat tatgcttatc gtcggattta tttagaacta   180
agaaatcgtg gttatctggt aaatcataaa agagttcaag gcttgataaa agtactcaat   240
ttacaagcta aaatgcgaca gaaacgaaaa tattcttctc ataaaggaga cgttggcaag   300
aaggcagaga atctcattca aggacaattt gaaggctcta aaacaatgga aaagtgctac   360
acagatgtga cagaatttgc cattccagca agtactcaaa agctttactt atcaccagtt   420
ttagatggct ttaacagtga aattattgct tttaatcttt cttgttcgcc taatttagaa   480
caagtacaaa caatgttgga acaggcattc aaagagaagc actacgagaa tacgattctc   540
catagtgacc aaggctggca atatcaacac gattcttatc atcggttcct agagagtaag   600
ggaattcaag catccatgtc acgtaagggc aacagccaag acaacggtag gatggaatct   660
ttctttggca ttttaaaatc cgaaatgttt tatggctatg agaaaacatt taaatcactt   720
aaccaattgg aacaagccat tatagactat attgattatt acaacaataa gaaaattaag   780
ataaaactaa aaggacttag tcctgtgcag tacagaacta aatcctttgg a            831

<210>   3026
<211>   277
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903382 (7.E-89)

<400>   3026
Met Thr Glu Phe Ser Leu Asp Ile Leu Leu Lys Ala Ile Lys Leu Ala 
1               5                   10                  15      

Arg Leu Thr Tyr Tyr Tyr His Leu Lys Gln Leu Asp Lys Pro Asp Lys 
            20                  25                  30          

Asp Gln Glu Leu Lys Ala Glu Ile Gln Ser Ile Phe Ile Glu His Lys 
        35                  40                  45              

Gly Asn Tyr Ala Tyr Arg Arg Ile Tyr Leu Glu Leu Arg Asn Arg Gly 
    50                  55                  60                  

Tyr Leu Val Asn His Lys Arg Val Gln Gly Leu Ile Lys Val Leu Asn 
65                  70                  75                  80  

Leu Gln Ala Lys Met Arg Gln Lys Arg Lys Tyr Ser Ser His Lys Gly 
                85                  90                  95      

Asp Val Gly Lys Lys Ala Glu Asn Leu Ile Gln Gly Gln Phe Glu Gly 
            100                 105                 110         

Ser Lys Thr Met Glu Lys Cys Tyr Thr Asp Val Thr Glu Phe Ala Ile 
        115                 120                 125             

Pro Ala Ser Thr Gln Lys Leu Tyr Leu Ser Pro Val Leu Asp Gly Phe 
    130                 135                 140                 

Asn Ser Glu Ile Ile Ala Phe Asn Leu Ser Cys Ser Pro Asn Leu Glu 
145                 150                 155                 160 

Gln Val Gln Thr Met Leu Glu Gln Ala Phe Lys Glu Lys His Tyr Glu 
                165                 170                 175     


Asn Thr Ile Leu His Ser Asp Gln Gly Trp Gln Tyr Gln His Asp Ser 
            180                 185                 190         

Tyr His Arg Phe Leu Glu Ser Lys Gly Ile Gln Ala Ser Met Ser Arg 
        195                 200                 205             

Lys Gly Asn Ser Gln Asp Asn Gly Arg Met Glu Ser Phe Phe Gly Ile 
    210                 215                 220                 

Leu Lys Ser Glu Met Phe Tyr Gly Tyr Glu Lys Thr Phe Lys Ser Leu 
225                 230                 235                 240 

Asn Gln Leu Glu Gln Ala Ile Ile Asp Tyr Ile Asp Tyr Tyr Asn Asn 
                245                 250                 255     

Lys Lys Ile Lys Ile Lys Leu Lys Gly Leu Ser Pro Val Gln Tyr Arg 
            260                 265                 270         

Thr Lys Ser Phe Gly 
        275         

<210>   3027
<211>   436
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3027
atgaaattaa cttatgatga taaagttcag atctatgaac ttagaaaaca aggatatagc   60
ttagagaagc tttcaaataa atttgggata aacaattcta atcttaggta catgattaaa   120
ttgattgatc gttacggaat agagttcgtc aaaaaaggaa aaaatcgtta ctattctcct   180
gatttaaaac aagaaatgat tcataaagtc tgacatgaag gctggactaa agatagagtt   240
tctcttgaat actgtctccc aagtcgtacg atacttctta actggctagc acaatacagg   300
aaaaacgggt atactattgt tgagaaaaca agagggagag tacctgagag cggagaatgc   360
catcctaaaa aagttaagag aactccgatt gaaggaggaa aaagagaaag aagaaagaca   420
gaaattattc aagaat                                                   436

<210>   3028
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, hypothetical protein, POINT MUTATION FRAMESHIFT

<400>   3028
Met Asn Cys Thr Pro Lys Val Arg Gln Lys Lys Ser Asn Phe Trp Gly 
1               5                   10                  15      

Val Phe Ile Met Lys Leu Thr Tyr Asp Asp Lys Val Gln Ile Tyr Glu 
            20                  25                  30          

Leu Arg Lys Gln Gly Tyr Ser Leu Glu Lys Leu Ser Asn Lys Phe Gly 
        35                  40                  45              

Ile Asn Asn Ser Asn Leu Arg Tyr Met Ile Lys Leu Ile Asp Arg Tyr 
    50                  55                  60                  

Gly Ile Glu Phe Val Lys Lys Gly Lys Asn Arg Tyr Tyr Ser Pro Asp 
65                  70                  75                  80  

Leu Lys Gln Glu Met Ile His Lys Val 
                85                  

<210>   3029
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3029
ttggcgaaat gtaaaaaata tgaggagttc ggactcgact ctctccttca agaaacacgt   60
ggtggtcgta accatgctta tatgacggtt gagcaagaga aagtctttct tgcccgccat   120
ttgaaggcta cagaggcagg agaatttgtt acaattgatg ccttatttca ggcttataaa   180
aaggagttag gtcgttccta cacacgtgat gccttctatc aactgttgaa gcgccatggt   240
tggcgaaata ttacgccacg tccagaacat cctaagaaag cagatgctca aaccattgtc   300
gcgtctaaaa ataaagtctc aattcaagaa gacaag                             336

<210>   3030
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Degenerate transposase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903385 (6.E-62)

<400>   3030
Met Ala Lys Cys Lys Lys Tyr Glu Glu Phe Gly Leu Asp Ser Leu Leu 
1               5                   10                  15      

Gln Glu Thr Arg Gly Gly Arg Asn His Ala Tyr Met Thr Val Glu Gln 
            20                  25                  30          

Glu Lys Val Phe Leu Ala Arg His Leu Lys Ala Thr Glu Ala Gly Glu 
        35                  40                  45              

Phe Val Thr Ile Asp Ala Leu Phe Gln Ala Tyr Lys Lys Glu Leu Gly 
    50                  55                  60                  

Arg Ser Tyr Thr Arg Asp Ala Phe Tyr Gln Leu Leu Lys Arg His Gly 
65                  70                  75                  80  

Trp Arg Asn Ile Thr Pro Arg Pro Glu His Pro Lys Lys Ala Asp Ala 
                85                  90                  95      

Gln Thr Ile Val Ala Ser Lys Asn Lys Val Ser Ile Gln Glu Asp Lys 
            100                 105                 110         


<210>   3031
<211>   138
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3031
atgaaatcaa ttaaagaaga aatccaaacc atcaaaacac ttttaaaaga ctctcgtaca   60
gctaaatatc ataaacgcct tcaaatcgtt ctatttcgtc tgatgggcaa atcttataaa   120
gagattatag aactttta                                                 138

<210>   3032
<211>   46
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3032
Met Lys Ser Ile Lys Glu Glu Ile Gln Thr Ile Lys Thr Leu Leu Lys 
1               5                   10                  15      


Asp Ser Arg Thr Ala Lys Tyr His Lys Arg Leu Gln Ile Val Leu Phe 
            20                  25                  30          

Arg Leu Met Gly Lys Ser Tyr Lys Glu Ile Ile Glu Leu Leu 
        35                  40                  45      

<210>   3033
<211>   1212
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3033
ttggaggctt ttactcaaat ggcaaaagaa aaatacgatc gtagtaaacc acacgttaac   60
attggtacta tcggacacgt tgaccacggt aaaactaccc taactgcagc tatcacaact   120
gttttggcac gtcgcttgcc ttcatcagtt aaccaaccta aagactatgc gtctatcgat   180
gctgctccag aagaacgcga acgcggtatc actatcaaca ctgcgcacgt tgagtacgaa   240
actgaaaaac gtcactacgc tcacatcgac gctccaggac acgcggacta cgttaaaaac   300
atgatcactg gtgctgctca aatggacgga gctatccttg tagtagcttc aactgacgga   360
ccaatgccac aaactcgtga gcacatcctt ctttcacgtc aggttggtgt taaacacctt   420
atcgtcttca tgaacaaagt tgacttggtt gacgacgaag aattgcttga attggttgaa   480
atggaaatcc gtgacctatt gtcagaatac gacttcccag gtgacgatct tccagttatc   540
caaggttcag cacttaaagc tcttgaaggt gactctaaat acgaagacat cgttatggaa   600
ttgatgaaca cagttgatga gtatatccca gaaccagaac gtgacactga caaaccattg   660
cttcttccag tcgaggacgt attctcaatc actggacgtg gtacagttgc ttcaggacgt   720
atcgaccgtg gtatcgttaa agtcaacgac gaaatcgaaa tcgttggtat caaagaagaa   780
actcaaaaag cagttgttac tggtgttgaa atgttccgta aacaacttga cgaaggtctt   840
gctggagata acgtaggtgt ccttcttcgt ggtgttcaac gtgatgaaat cgaacgtgga   900
caagttatcg ctaaaccagg ttcaatcaac ccacacacta aattcaaagg tgaagtctac   960
atccttacta aagaagaagg tggacgtcac actccattct tcaacaacta ccgtccacaa   1020
ttctacttcc gtactactga cgttacaggt tcaatcgaac ttccagcagg tactgaaatg   1080
gtaatgcctg gtgataacgt gacaatcgac gttgagttga ttcacccaat cgccgtagaa   1140
caaggtacta cattctctat ccgtgagggt ggacgtactg ttggttcagg tatggttaca   1200
gaaatcgaag ct                                                       1212

<210>   3034
<211>   404
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   translation elongation factor TU (tuf)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903386 (0.E+01)

<400>   3034
Met Glu Ala Phe Thr Gln Met Ala Lys Glu Lys Tyr Asp Arg Ser Lys 
1               5                   10                  15      

Pro His Val Asn Ile Gly Thr Ile Gly His Val Asp His Gly Lys Thr 
            20                  25                  30          

Thr Leu Thr Ala Ala Ile Thr Thr Val Leu Ala Arg Arg Leu Pro Ser 
        35                  40                  45              

Ser Val Asn Gln Pro Lys Asp Tyr Ala Ser Ile Asp Ala Ala Pro Glu 
    50                  55                  60                  

Glu Arg Glu Arg Gly Ile Thr Ile Asn Thr Ala His Val Glu Tyr Glu 
65                  70                  75                  80  

Thr Glu Lys Arg His Tyr Ala His Ile Asp Ala Pro Gly His Ala Asp 
                85                  90                  95      

Tyr Val Lys Asn Met Ile Thr Gly Ala Ala Gln Met Asp Gly Ala Ile 
            100                 105                 110         

Leu Val Val Ala Ser Thr Asp Gly Pro Met Pro Gln Thr Arg Glu His 
        115                 120                 125             

Ile Leu Leu Ser Arg Gln Val Gly Val Lys His Leu Ile Val Phe Met 
    130                 135                 140                 

Asn Lys Val Asp Leu Val Asp Asp Glu Glu Leu Leu Glu Leu Val Glu 
145                 150                 155                 160 

Met Glu Ile Arg Asp Leu Leu Ser Glu Tyr Asp Phe Pro Gly Asp Asp 
                165                 170                 175     

Leu Pro Val Ile Gln Gly Ser Ala Leu Lys Ala Leu Glu Gly Asp Ser 
            180                 185                 190         

Lys Tyr Glu Asp Ile Val Met Glu Leu Met Asn Thr Val Asp Glu Tyr 
        195                 200                 205             

Ile Pro Glu Pro Glu Arg Asp Thr Asp Lys Pro Leu Leu Leu Pro Val 
    210                 215                 220                 

Glu Asp Val Phe Ser Ile Thr Gly Arg Gly Thr Val Ala Ser Gly Arg 
225                 230                 235                 240 

Ile Asp Arg Gly Ile Val Lys Val Asn Asp Glu Ile Glu Ile Val Gly 
                245                 250                 255     

Ile Lys Glu Glu Thr Gln Lys Ala Val Val Thr Gly Val Glu Met Phe 
            260                 265                 270         

Arg Lys Gln Leu Asp Glu Gly Leu Ala Gly Asp Asn Val Gly Val Leu 
        275                 280                 285             

Leu Arg Gly Val Gln Arg Asp Glu Ile Glu Arg Gly Gln Val Ile Ala 
    290                 295                 300                 

Lys Pro Gly Ser Ile Asn Pro His Thr Lys Phe Lys Gly Glu Val Tyr 
305                 310                 315                 320 

Ile Leu Thr Lys Glu Glu Gly Gly Arg His Thr Pro Phe Phe Asn Asn 
                325                 330                 335     

Tyr Arg Pro Gln Phe Tyr Phe Arg Thr Thr Asp Val Thr Gly Ser Ile 
            340                 345                 350         

Glu Leu Pro Ala Gly Thr Glu Met Val Met Pro Gly Asp Asn Val Thr 
        355                 360                 365             

Ile Asp Val Glu Leu Ile His Pro Ile Ala Val Glu Gln Gly Thr Thr 
    370                 375                 380                 

Phe Ser Ile Arg Glu Gly Gly Arg Thr Val Gly Ser Gly Met Val Thr 
385                 390                 395                 400 

Glu Ile Glu Ala 
                

<210>   3035
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3035
ttgttagaaa tcgatttgac tgtcctgaac gatttgccct attcttgttt cattttacta   60
tataaaccag agactgttta cattttcagc aag                                93

<210>   3036
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902350 (6.E-05)

<400>   3036
Met Leu Glu Ile Asp Leu Thr Val Leu Asn Asp Leu Pro Tyr Ser Cys 
1               5                   10                  15      

Phe Ile Leu Leu Tyr Lys Pro Glu Thr Val Tyr Ile Phe Ser Lys 
            20                  25                  30      

<210>   3037
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3037
ttgactctgc tgagtcctat gattgttatc gttttatctg caattttata ctcaatgaaa   60
atcaaagggc aaactaagaa gctagccgca ggttgttcaa aacacagttt tgaggttgta   120

<210>   3038
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3038
Met Thr Leu Leu Ser Pro Met Ile Val Ile Val Leu Ser Ala Ile Leu 
1               5                   10                  15      

Tyr Ser Met Lys Ile Lys Gly Gln Thr Lys Lys Leu Ala Ala Gly Cys 
            20                  25                  30          

Ser Lys His Ser Phe Glu Val Val 
        35                  40  

<210>   3039
<211>   867
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3039
atggatttca catgggcact gaagtatgcc actgaatttt tgggaactgc cattttgatc   60
attcttggga atggtgcagt tgccaacgtt gaacttaaag gtacgaaagg tcaccaaagt   120
ggctggatcg tcatcgctgt tggttatggt atgggggtta tgatcccagc cttgatgttt   180
ggtaacgtat ctgggaatca catcaaccct gctttcactc tagggcttgc agttagcggt   240
cttttccctt gggcacaagt ggtaccttac attatcgcgc aagtcttggg ggctatcttt   300
ggccaagcct tagttgtggc aacataccgt ccattctact tgaaaactga aaacccaaat   360
aacatcttgg gaactttctc aactatttca agtattgacc atggtacaaa agaaagtcgc   420
tatgcagcaa ctgtcaatgg tttgattaat gagtttgttg gttcatttgt tttgttcttt   480
gcagctcttg gtttgactaa aaacttcttt ggtgctgaag tgcttcaatt catgaaacaa   540
aaggcaacag aagcaggaca aacagttgat ttttctgact tggctattaa agcacaggtg   600
gctccacaca ctgcttcagg actttctgtg gctcacttgg cacttggatt cctcgttatg   660
gctttggtaa catcacttgg aggacctaca ggacctgcct tgaacccagc ccgtgacttg   720
ggaccacgtc tccttcatgc tttccttccc aaatcagttc ttggtgagca taaaggcgat   780
tcaaaatggt ggtattcttg ggtaccagta gtagcaccta tcgcagcagc aattgcggca   840
gtagctgtat tcaaattcct ttatctc                                       867

<210>   3040
<211>   289
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycerol uptake facilitator protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903387 (e-166)

<400>   3040
Met Asp Phe Thr Trp Ala Leu Lys Tyr Ala Thr Glu Phe Leu Gly Thr 
1               5                   10                  15      

Ala Ile Leu Ile Ile Leu Gly Asn Gly Ala Val Ala Asn Val Glu Leu 
            20                  25                  30          

Lys Gly Thr Lys Gly His Gln Ser Gly Trp Ile Val Ile Ala Val Gly 
        35                  40                  45              

Tyr Gly Met Gly Val Met Ile Pro Ala Leu Met Phe Gly Asn Val Ser 
    50                  55                  60                  

Gly Asn His Ile Asn Pro Ala Phe Thr Leu Gly Leu Ala Val Ser Gly 
65                  70                  75                  80  

Leu Phe Pro Trp Ala Gln Val Val Pro Tyr Ile Ile Ala Gln Val Leu 
                85                  90                  95      

Gly Ala Ile Phe Gly Gln Ala Leu Val Val Ala Thr Tyr Arg Pro Phe 
            100                 105                 110         

Tyr Leu Lys Thr Glu Asn Pro Asn Asn Ile Leu Gly Thr Phe Ser Thr 
        115                 120                 125             

Ile Ser Ser Ile Asp His Gly Thr Lys Glu Ser Arg Tyr Ala Ala Thr 
    130                 135                 140                 

Val Asn Gly Leu Ile Asn Glu Phe Val Gly Ser Phe Val Leu Phe Phe 
145                 150                 155                 160 

Ala Ala Leu Gly Leu Thr Lys Asn Phe Phe Gly Ala Glu Val Leu Gln 
                165                 170                 175     

Phe Met Lys Gln Lys Ala Thr Glu Ala Gly Gln Thr Val Asp Phe Ser 
            180                 185                 190         

Asp Leu Ala Ile Lys Ala Gln Val Ala Pro His Thr Ala Ser Gly Leu 
        195                 200                 205             

Ser Val Ala His Leu Ala Leu Gly Phe Leu Val Met Ala Leu Val Thr 
    210                 215                 220                 

Ser Leu Gly Gly Pro Thr Gly Pro Ala Leu Asn Pro Ala Arg Asp Leu 
225                 230                 235                 240 

Gly Pro Arg Leu Leu His Ala Phe Leu Pro Lys Ser Val Leu Gly Glu 
                245                 250                 255     

His Lys Gly Asp Ser Lys Trp Trp Tyr Ser Trp Val Pro Val Val Ala 
            260                 265                 270         

Pro Ile Ala Ala Ala Ile Ala Ala Val Ala Val Phe Lys Phe Leu Tyr 
        275                 280                 285             

Leu 
    

<210>   3041
<211>   606
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3041
gtggttccca aaacagcaac ctctactgag acgaagacta taacgcgtat cattcattac   60
gttgataaag ttacgaacca aaatgtaaaa gaagatgttg ttcaacctgt aaccttaagc   120
cgtacaaaaa ctgagaacaa ggtcacggga gttgtaacct acggtgaatg gacaacagga   180
aactgggacg aggttatatc tggtaagatt gacaagtaca aagatccaga tattccaaca   240
gttgaatcac aagaagttac gtcagactct agtgataaag aaataacggt aaggtatgac   300
cgtttatcaa caccagaaaa accaatccca caaccaaatc cagagcatcc aagtgttccg   360
acaccaaacc cagaactacc aaatcaagag actccaacac cagataaacc aactccagaa   420
ccaggtactc caaaaactga aactccagtg aatccagacc cagaagttcc gacttatgag   480
acaggtaaga gagaggaatt gccaaacaca ggtacagaag ctaatgctac cttggctagt   540
gctggtatca tgaccttgtt agctggtcta ggattaggat ttttcaagaa aaaagaagat   600
gaaaaa                                                              606

<210>   3042
<211>   202
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell wall surface anchor family protein
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15903388 (e-118)

<400>   3042
Met Val Pro Lys Thr Ala Thr Ser Thr Glu Thr Lys Thr Ile Thr Arg 
1               5                   10                  15      

Ile Ile His Tyr Val Asp Lys Val Thr Asn Gln Asn Val Lys Glu Asp 
            20                  25                  30          

Val Val Gln Pro Val Thr Leu Ser Arg Thr Lys Thr Glu Asn Lys Val 
        35                  40                  45              

Thr Gly Val Val Thr Tyr Gly Glu Trp Thr Thr Gly Asn Trp Asp Glu 
    50                  55                  60                  

Val Ile Ser Gly Lys Ile Asp Lys Tyr Lys Asp Pro Asp Ile Pro Thr 
65                  70                  75                  80  

Val Glu Ser Gln Glu Val Thr Ser Asp Ser Ser Asp Lys Glu Ile Thr 
                85                  90                  95      

Val Arg Tyr Asp Arg Leu Ser Thr Pro Glu Lys Pro Ile Pro Gln Pro 
            100                 105                 110         

Asn Pro Glu His Pro Ser Val Pro Thr Pro Asn Pro Glu Leu Pro Asn 
        115                 120                 125             

Gln Glu Thr Pro Thr Pro Asp Lys Pro Thr Pro Glu Pro Gly Thr Pro 
    130                 135                 140                 

Lys Thr Glu Thr Pro Val Asn Pro Asp Pro Glu Val Pro Thr Tyr Glu 
145                 150                 155                 160 

Thr Gly Lys Arg Glu Glu Leu Pro Asn Thr Gly Thr Glu Ala Asn Ala 
                165                 170                 175     

Thr Leu Ala Ser Ala Gly Ile Met Thr Leu Leu Ala Gly Leu Gly Leu 
            180                 185                 190         

Gly Phe Phe Lys Lys Lys Glu Asp Glu Lys 
        195                 200         

<210>   3043
<211>   1110
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3043
gtgccgatga atataattct aatcgccaaa cttttgagag agaatacaaa tacaaaagca   60
aatgccctta ataatggttg ggctagatct ggttctgaag agttcaaaaa gttctcccac   120
tttgtagggg tagacaaagg gattgtgcga acgaatgtac tgactggtaa aaaactatct   180
gataagatta ggaaagaagt gggctctgga gatagcaaac taggaaaagg cggctatttc   240
tctactgggg atgttctatt aggaaaagat gttgtttctt ataccgtaca agtattttca   300
gagaataatg aaagagtagg agtaaacact caaagtcacc gtgttcagta taatctccca   360
attctagctg acttttcagt catccaagat actgtggaac catcacgaac cgttgttgaa   420
aaaatcattc caaaactaaa tattcccgaa gaagagaaag ggaaaataac cgaagaaatc   480
aagaaaaaga aaaaaacctc agaattggca gaactaatct cagaaaatgt gaaagttcgc   540
tatgttgatg aacaagggcg tttgctatca ttgaaaaatg atactggaat tggagaaaaa   600
gaaagtgacg gaacctacat taccaataaa aaacaactga ttggtaccag ctataatgtc   660
acagataaaa aactcagtag catgactact actgacggaa aatattatac ttttaaagaa   720
gcagatacaa attctgcaag tttaactggg aatattgtaa gcgaaggtag aacagtgacc   780
ttagtttata gagaaagcga agcgccaacc actgctacag taacagccaa ttactataaa   840
gaaggtaggc aagagaagtt ggtagagtct gttataaaag ctgatttagc gataggttct   900
gagtatacca cagaatcaaa aactattgaa gggaaaacaa caactgagga caaagaagac   960
cgagttatca caaggaaaac aacatacacc ttggtagcaa ctcctgaaaa tgcgtaccag   1020
aagacggtgc aacagttgac tattactacc gtgagaatgt tgaggaaaca gtggttccca   1080
aaacagcaac ctctactgag acgaagacta                                    1110

<210>   3044
<211>   370
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903389 (0.E+01)

<400>   3044
Met Pro Met Asn Ile Ile Leu Ile Ala Lys Leu Leu Arg Glu Asn Thr 
1               5                   10                  15      

Asn Thr Lys Ala Asn Ala Leu Asn Asn Gly Trp Ala Arg Ser Gly Ser 
            20                  25                  30          

Glu Glu Phe Lys Lys Phe Ser His Phe Val Gly Val Asp Lys Gly Ile 
        35                  40                  45              

Val Arg Thr Asn Val Leu Thr Gly Lys Lys Leu Ser Asp Lys Ile Arg 
    50                  55                  60                  

Lys Glu Val Gly Ser Gly Asp Ser Lys Leu Gly Lys Gly Gly Tyr Phe 
65                  70                  75                  80  

Ser Thr Gly Asp Val Leu Leu Gly Lys Asp Val Val Ser Tyr Thr Val 
                85                  90                  95      

Gln Val Phe Ser Glu Asn Asn Glu Arg Val Gly Val Asn Thr Gln Ser 
            100                 105                 110         

His Arg Val Gln Tyr Asn Leu Pro Ile Leu Ala Asp Phe Ser Val Ile 
        115                 120                 125             

Gln Asp Thr Val Glu Pro Ser Arg Thr Val Val Glu Lys Ile Ile Pro 
    130                 135                 140                 

Lys Leu Asn Ile Pro Glu Glu Glu Lys Gly Lys Ile Thr Glu Glu Ile 
145                 150                 155                 160 

Lys Lys Lys Lys Lys Thr Ser Glu Leu Ala Glu Leu Ile Ser Glu Asn 
                165                 170                 175     

Val Lys Val Arg Tyr Val Asp Glu Gln Gly Arg Leu Leu Ser Leu Lys 
            180                 185                 190         

Asn Asp Thr Gly Ile Gly Glu Lys Glu Ser Asp Gly Thr Tyr Ile Thr 
        195                 200                 205             

Asn Lys Lys Gln Leu Ile Gly Thr Ser Tyr Asn Val Thr Asp Lys Lys 
    210                 215                 220                 

Leu Ser Ser Met Thr Thr Thr Asp Gly Lys Tyr Tyr Thr Phe Lys Glu 
225                 230                 235                 240 

Ala Asp Thr Asn Ser Ala Ser Leu Thr Gly Asn Ile Val Ser Glu Gly 
                245                 250                 255     

Arg Thr Val Thr Leu Val Tyr Arg Glu Ser Glu Ala Pro Thr Thr Ala 
            260                 265                 270         

Thr Val Thr Ala Asn Tyr Tyr Lys Glu Gly Arg Gln Glu Lys Leu Val 
        275                 280                 285             

Glu Ser Val Ile Lys Ala Asp Leu Ala Ile Gly Ser Glu Tyr Thr Thr 
    290                 295                 300                 

Glu Ser Lys Thr Ile Glu Gly Lys Thr Thr Thr Glu Asp Lys Glu Asp 
305                 310                 315                 320 

Arg Val Ile Thr Arg Lys Thr Thr Tyr Thr Leu Val Ala Thr Pro Glu 
                325                 330                 335     

Asn Ala Tyr Gln Lys Thr Val Gln Gln Leu Thr Ile Thr Thr Val Arg 
            340                 345                 350         

Met Leu Arg Lys Gln Trp Phe Pro Lys Gln Gln Pro Leu Leu Arg Arg 
        355                 360                 365             

Arg Leu 
    370 

<210>   3045
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3045
gtgttgaatg ttgaccagga tttcatgagc atatctaagt ctaataaaag tggttcagac   60
tggaagaaaa ctttcacagt gaggataacc aataggctag caaatgactt gaataatgtc   120
ttgaaacagg ttgataaaga tactcctaat accccaactt ggctaaactc agctgcttct   180
aaagctaaag atgatgacag agtatataaa ctactgaaga ctcttatacc aggagaaaat   240
tacctatcat gt                                                       252

<210>   3046
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903390 (4.E-45)

<400>   3046
Met Leu Asn Val Asp Gln Asp Phe Met Ser Ile Ser Lys Ser Asn Lys 
1               5                   10                  15      

Ser Gly Ser Asp Trp Lys Lys Thr Phe Thr Val Arg Ile Thr Asn Arg 
            20                  25                  30          

Leu Ala Asn Asp Leu Asn Asn Val Leu Lys Gln Val Asp Lys Asp Thr 
        35                  40                  45              

Pro Asn Thr Pro Thr Trp Leu Asn Ser Ala Ala Ser Lys Ala Lys Asp 
    50                  55                  60                  

Asp Asp Arg Val Tyr Lys Leu Leu Lys Thr Leu Ile Pro Gly Glu Asn 
65                  70                  75                  80  

Tyr Leu Ser Cys 
                

<210>   3047
<211>   207
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3047
ttgaatgttg aacttgcgca ccaacaaatt aagggatttt ttgaagcaga gtttaaaaat   60
cgtattaatg gagttcttaa tactaaaata aaaaatagta cattaaatcg tgtaaataaa   120
aaaactatac accagagcaa caaaaactcc atgatcaatt tgaagcagaa gcaacggaag   180
atgctaaaaa acaaggcgat attgtgt                                       207

<210>   3048
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903391 (2.E-42)

<400>   3048
Met Asn Val Glu Leu Ala His Gln Gln Ile Lys Gly Phe Phe Glu Ala 
1               5                   10                  15      

Glu Phe Lys Asn Arg Ile Asn Gly Val Leu Asn Thr Lys Ile Lys Asn 
            20                  25                  30          

Ser Thr Leu Asn Arg Val Asn Lys Lys Thr Ile His Gln Ser Asn Lys 
        35                  40                  45              

Asn Ser Met Ile Asn Leu Lys Gln Lys Gln Arg Lys Met Leu Lys Asn 
    50                  55                  60                  

Lys Ala Ile Leu Cys 
65                  

<210>   3049
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3049
ttgaatgttt ggaatgcttt tttaaaacta gatgactata acggttctaa aggaacctat   60
cgagtagtca ttaaaactaa ggatactgct ggt                                93

<210>   3050
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3050
Met Asn Val Trp Asn Ala Phe Leu Lys Leu Asp Asp Tyr Asn Gly Ser 
1               5                   10                  15      

Lys Gly Thr Tyr Arg Val Val Ile Lys Thr Lys Asp Thr Ala Gly 
            20                  25                  30      

<210>   3051
<211>   297
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3051
atgatttaca agaaaagcat gacaagcgat ttctttgtgg agtggttcaa aacgcaactc   60
ctacctgctt tgaagacacc tcatgttatt gtcatgggca atgctggttt tcatcccaag   120
aacattttgg atgaactctg catccaagat aaacactttt tcttacctct accaccttat   180
tcaccggatt tgaatcctat tgagcaagct tgggctatct tgaaaaagaa agtgacggat   240
gtattaaggg aagttccaac tatttttgaa tgtttggaat gcttttttaa aactaga      297

<210>   3052
<211>   99
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, IS630-Spn1 related, Orf2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903392 (6.E-57)

<400>   3052
Met Ile Tyr Lys Lys Ser Met Thr Ser Asp Phe Phe Val Glu Trp Phe 
1               5                   10                  15      

Lys Thr Gln Leu Leu Pro Ala Leu Lys Thr Pro His Val Ile Val Met 

            20                  25                  30          

Gly Asn Ala Gly Phe His Pro Lys Asn Ile Leu Asp Glu Leu Cys Ile 
        35                  40                  45              

Gln Asp Lys His Phe Phe Leu Pro Leu Pro Pro Tyr Ser Pro Asp Leu 
    50                  55                  60                  

Asn Pro Ile Glu Gln Ala Trp Ala Ile Leu Lys Lys Lys Val Thr Asp 
65                  70                  75                  80  

Val Leu Arg Glu Val Pro Thr Ile Phe Glu Cys Leu Glu Cys Phe Phe 
                85                  90                  95      

Lys Thr Arg 
            

<210>   3053
<211>   213
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3053
gtgggaaaag aaagacgtga acaagaacac atagagagga aaaagcgagt cgtcaaaaac   60
cgaaagattc ctttagagga attgaaagcc tttgtagagg ctcatccaga tgctttttta   120
cgggaaattg cggcacattt tgattgtgct gttccttcag tatgggcagc tttaaagcag   180
attaaggtca ctttaaaaaa agatgacgag ctt                                213

<210>   3054
<211>   71
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, IS630-Spn1 related, Orf1 FRAMESHIFT

<400>   3054
Met Gly Lys Glu Arg Arg Glu Gln Glu His Ile Glu Arg Lys Lys Arg 
1               5                   10                  15      

Val Val Lys Asn Arg Lys Ile Pro Leu Glu Glu Leu Lys Ala Phe Val 
            20                  25                  30          

Glu Ala His Pro Asp Ala Phe Leu Arg Glu Ile Ala Ala His Phe Asp 
        35                  40                  45              

Cys Ala Val Pro Ser Val Trp Ala Ala Leu Lys Gln Ile Lys Val Thr 
    50                  55                  60                  

Leu Lys Lys Asp Asp Glu Leu 
65                  70      

<210>   3055
<211>   1716
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3055
atgtcttacc aagaaaatta ccagaaatgg gttgattttg tggagcttcc tgactacctt   60
cgtcaagatt tggaaaatat ggacgaaaaa actaaggaag atgccttcta tacaaatctt   120
gaatttggta ctgcaggtat gcgtggcttg gttggtgctg gtacaaaccg tatcaacatc   180
tacgttgttc gccaagctac tgaaggattg gctcgtttga ttgagtcaaa aggtggaaac   240
gagaaagaac gcggtgtagc aattgcctac gatagccgtc acttctcacc tgagtttgcc   300
tttgaatctg cggcagttct tgctaaacac ggcatcaaat cttacgtatt tgaaagcctt   360
cgtccgactc cagaactatc atttgcagtt cgtcatctca actgtttcgc aggtatcatg   420
gtcacagcca gccacaaccc tgctccattt aacggttaca aggtttacgg tgaagacggt   480
ggacaaatgc ctccacacga tgcggacgct ttgactactt atatccgtgc aatcgaaaac   540
ccatttgcag ttgaagttgc tgatgtggaa actgaaaaag cttctggctt gattgaagtt   600
atcggcgaag ctgttgacat agaatacctt aaagaggtta aggacataaa catcaaccca   660
gccttgattg aagaatttgg taaagacatg aagattgtct acacaccact tcatggtact   720
ggtgaaatgt tggctcgtcg tgctcttgcc caagcaggat ttgactctgt tcaagttgtt   780
gaagcgcaag caactgctga cccagacttt tcaactgtaa catctccaaa cccagaaagc   840
caagcagcct ttgcccttgc tgaagaactt ggtcgtcaag ttggtgcaga tgttcttgtc   900
gcaactgacc cagacgctga ccgtgttggt gttgaagttc ttcaaaaaga tggtagctac   960
ctcaaccttt caggtaacca aatcggtgct atcatggcta aatacatctt ggaagctcac   1020
aaaaacgctg gaactcttcc tgaaaatgcc gctctctgca aatctatcgt ttcaactgac   1080
ttggtaacga agattgctga aagctacggc gcaactatgt tcaacgtctt gacaggtttc   1140
aaatttatcg ctgaaaaaat ccaagaattc gaagaaaaac acaaccacac ttacatgatg   1200
ggatttgaag aaagcttcgg ttacttgatt aaaccatttg tacgtgataa agatgccatc   1260
caagccgttc ttgtagttgc tgaacttgct gcctactacc gttctcgtgg tttgacactt   1320
gctgacggta tcgaagaaat ctataaagaa tatggctact acgcagaaaa aacaatctct   1380
gttactcttt caggtgtcga tggtgctgaa caaatcaaag cgattatggc taaattccgc   1440
aacaatgctc caacagaatg gaacgcaaca gctatcactg tcgtagaaga cttcaaggca   1500
caaactgcta ctgttgctga cggtactgtt acaaacttga caactcctcc aagtgatgtg   1560
ttgaaataca cacttgctga cggttcatgg attgccgttc gcccttcagg tacagaacca   1620
aaaatcaagt tctacattgc agttgtaggg gaaaccaacg aagaatcaca agctaagatt   1680
gctaacatcg aagcagaaat caatgcattt gtaaaa                             1716

<210>   3056
<211>   572
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoglucomutase (pgm)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903394 (0.E+01)

<400>   3056
Met Ser Tyr Gln Glu Asn Tyr Gln Lys Trp Val Asp Phe Val Glu Leu 
1               5                   10                  15      

Pro Asp Tyr Leu Arg Gln Asp Leu Glu Asn Met Asp Glu Lys Thr Lys 
            20                  25                  30          

Glu Asp Ala Phe Tyr Thr Asn Leu Glu Phe Gly Thr Ala Gly Met Arg 
        35                  40                  45              

Gly Leu Val Gly Ala Gly Thr Asn Arg Ile Asn Ile Tyr Val Val Arg 
    50                  55                  60                  

Gln Ala Thr Glu Gly Leu Ala Arg Leu Ile Glu Ser Lys Gly Gly Asn 
65                  70                  75                  80  

Glu Lys Glu Arg Gly Val Ala Ile Ala Tyr Asp Ser Arg His Phe Ser 
                85                  90                  95      

Pro Glu Phe Ala Phe Glu Ser Ala Ala Val Leu Ala Lys His Gly Ile 
            100                 105                 110         

Lys Ser Tyr Val Phe Glu Ser Leu Arg Pro Thr Pro Glu Leu Ser Phe 
        115                 120                 125             

Ala Val Arg His Leu Asn Cys Phe Ala Gly Ile Met Val Thr Ala Ser 
    130                 135                 140                 

His Asn Pro Ala Pro Phe Asn Gly Tyr Lys Val Tyr Gly Glu Asp Gly 
145                 150                 155                 160 

Gly Gln Met Pro Pro His Asp Ala Asp Ala Leu Thr Thr Tyr Ile Arg 
                165                 170                 175     

Ala Ile Glu Asn Pro Phe Ala Val Glu Val Ala Asp Val Glu Thr Glu 
            180                 185                 190         

Lys Ala Ser Gly Leu Ile Glu Val Ile Gly Glu Ala Val Asp Ile Glu 
        195                 200                 205             

Tyr Leu Lys Glu Val Lys Asp Ile Asn Ile Asn Pro Ala Leu Ile Glu 
    210                 215                 220                 

Glu Phe Gly Lys Asp Met Lys Ile Val Tyr Thr Pro Leu His Gly Thr 
225                 230                 235                 240 

Gly Glu Met Leu Ala Arg Arg Ala Leu Ala Gln Ala Gly Phe Asp Ser 
                245                 250                 255     

Val Gln Val Val Glu Ala Gln Ala Thr Ala Asp Pro Asp Phe Ser Thr 
            260                 265                 270         

Val Thr Ser Pro Asn Pro Glu Ser Gln Ala Ala Phe Ala Leu Ala Glu 
        275                 280                 285             

Glu Leu Gly Arg Gln Val Gly Ala Asp Val Leu Val Ala Thr Asp Pro 
    290                 295                 300                 

Asp Ala Asp Arg Val Gly Val Glu Val Leu Gln Lys Asp Gly Ser Tyr 
305                 310                 315                 320 

Leu Asn Leu Ser Gly Asn Gln Ile Gly Ala Ile Met Ala Lys Tyr Ile 
                325                 330                 335     

Leu Glu Ala His Lys Asn Ala Gly Thr Leu Pro Glu Asn Ala Ala Leu 
            340                 345                 350         

Cys Lys Ser Ile Val Ser Thr Asp Leu Val Thr Lys Ile Ala Glu Ser 
        355                 360                 365             

Tyr Gly Ala Thr Met Phe Asn Val Leu Thr Gly Phe Lys Phe Ile Ala 
    370                 375                 380                 

Glu Lys Ile Gln Glu Phe Glu Glu Lys His Asn His Thr Tyr Met Met 
385                 390                 395                 400 

Gly Phe Glu Glu Ser Phe Gly Tyr Leu Ile Lys Pro Phe Val Arg Asp 
                405                 410                 415     

Lys Asp Ala Ile Gln Ala Val Leu Val Val Ala Glu Leu Ala Ala Tyr 
            420                 425                 430         

Tyr Arg Ser Arg Gly Leu Thr Leu Ala Asp Gly Ile Glu Glu Ile Tyr 
        435                 440                 445             

Lys Glu Tyr Gly Tyr Tyr Ala Glu Lys Thr Ile Ser Val Thr Leu Ser 
    450                 455                 460                 

Gly Val Asp Gly Ala Glu Gln Ile Lys Ala Ile Met Ala Lys Phe Arg 
465                 470                 475                 480 

Asn Asn Ala Pro Thr Glu Trp Asn Ala Thr Ala Ile Thr Val Val Glu 
                485                 490                 495     

Asp Phe Lys Ala Gln Thr Ala Thr Val Ala Asp Gly Thr Val Thr Asn 
            500                 505                 510         

Leu Thr Thr Pro Pro Ser Asp Val Leu Lys Tyr Thr Leu Ala Asp Gly 
        515                 520                 525             

Ser Trp Ile Ala Val Arg Pro Ser Gly Thr Glu Pro Lys Ile Lys Phe 
    530                 535                 540                 

Tyr Ile Ala Val Val Gly Glu Thr Asn Glu Glu Ser Gln Ala Lys Ile 
545                 550                 555                 560 

Ala Asn Ile Glu Ala Glu Ile Asn Ala Phe Val Lys 
                565                 570         

<210>   3057
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3057
atggaacaat ttttagataa catcaaagac cttgaagtca ctacagttgt gcgtgcgcaa   60
gaagctcttg ataaaaaaga aactgcaacc ttctttatcg gtcgcaaaac ttgcccttac   120
tgccgtaaat ttgcaggtac attgtcaggt gtcgtagctg aaaccaaagc tcacatttac   180
ttcatcaata gtgaagaacc aagccaactc aatgatttgc aagcattccg ctcacgctat   240
ggaatcccaa ctgtaccagg ttttgttcat attacagatg gacaaatcaa cgtccgttgc   300
gactcttcaa tgtcagcaca agaaatcaaa gatttcgcag gattg                   345

<210>   3058
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacterocin transport accessory protein (bta)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903395 (2.E-63)

<400>   3058
Met Glu Gln Phe Leu Asp Asn Ile Lys Asp Leu Glu Val Thr Thr Val 
1               5                   10                  15      

Val Arg Ala Gln Glu Ala Leu Asp Lys Lys Glu Thr Ala Thr Phe Phe 
            20                  25                  30          

Ile Gly Arg Lys Thr Cys Pro Tyr Cys Arg Lys Phe Ala Gly Thr Leu 
        35                  40                  45              

Ser Gly Val Val Ala Glu Thr Lys Ala His Ile Tyr Phe Ile Asn Ser 
    50                  55                  60                  

Glu Glu Pro Ser Gln Leu Asn Asp Leu Gln Ala Phe Arg Ser Arg Tyr 
65                  70                  75                  80  

Gly Ile Pro Thr Val Pro Gly Phe Val His Ile Thr Asp Gly Gln Ile 
                85                  90                  95      

Asn Val Arg Cys Asp Ser Ser Met Ser Ala Gln Glu Ile Lys Asp Phe 
            100                 105                 110         

Ala Gly Leu 
        115 

<210>   3059
<211>   834
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3059
atgaaaaaat ggatgcttgt attagtcagt ctgatgactg ctttgttctt agtagcttgt   60
gggaaaaatt ctagcgaaac tagtggagat aattggtcaa agtaccagtc taacaagtct   120
attactattg gatttgatag tacttttgtt ccaatgggat ttgctcagaa agatggttct   180
tatgcaggat ttgatattga tttagctaca gctgtttttg aaaaatacgg aatcacggta   240
aattggcaac cgattgattg ggatttgaaa gaagctgaat tgacaaaagg aacgattgat   300
ctgatttgga atggctattc cgctacagac gaacgccgtg aaaaggtggc tttcagtaac   360
tcatatatga agaatgagca ggtattggtt acgaagaaat catctggtat cacgactgca   420
aaggatatga ctggaaagac attaggagct caagctggtt catctggtta tgcggacttt   480
gaagcaaatc cagaaatttt gaagaatatt gtcgctaata aggaagcgaa tcaataccaa   540
acctttaatg aagccttgat tgatttgaaa aacgatcgaa ttgatggtct attgattgac   600
cgtgtctatg caaactatta tttagaagca gaaggtgttt taaacgatta taatgtcttt   660
acagttggac tagaaacaga agcttttgcg gttggagccc gtaaggaaga tacaaacttg   720
gttaagaaga taaatgaagc tttttctagt ctttacaagg acggcaagtt ccaagaaatc   780
agccaaaaat ggtttggaga agatgtagca accaaagaag taaaagaagg acag         834

<210>   3060
<211>   278
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, amino acid-binding protein (aatB)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903396 (e-160)

<400>   3060
Met Lys Lys Trp Met Leu Val Leu Val Ser Leu Met Thr Ala Leu Phe 
1               5                   10                  15      

Leu Val Ala Cys Gly Lys Asn Ser Ser Glu Thr Ser Gly Asp Asn Trp 
            20                  25                  30          

Ser Lys Tyr Gln Ser Asn Lys Ser Ile Thr Ile Gly Phe Asp Ser Thr 
        35                  40                  45              

Phe Val Pro Met Gly Phe Ala Gln Lys Asp Gly Ser Tyr Ala Gly Phe 
    50                  55                  60                  

Asp Ile Asp Leu Ala Thr Ala Val Phe Glu Lys Tyr Gly Ile Thr Val 
65                  70                  75                  80  

Asn Trp Gln Pro Ile Asp Trp Asp Leu Lys Glu Ala Glu Leu Thr Lys 
                85                  90                  95      

Gly Thr Ile Asp Leu Ile Trp Asn Gly Tyr Ser Ala Thr Asp Glu Arg 
            100                 105                 110         

Arg Glu Lys Val Ala Phe Ser Asn Ser Tyr Met Lys Asn Glu Gln Val 
        115                 120                 125             

Leu Val Thr Lys Lys Ser Ser Gly Ile Thr Thr Ala Lys Asp Met Thr 
    130                 135                 140                 

Gly Lys Thr Leu Gly Ala Gln Ala Gly Ser Ser Gly Tyr Ala Asp Phe 
145                 150                 155                 160 

Glu Ala Asn Pro Glu Ile Leu Lys Asn Ile Val Ala Asn Lys Glu Ala 
                165                 170                 175     

Asn Gln Tyr Gln Thr Phe Asn Glu Ala Leu Ile Asp Leu Lys Asn Asp 
            180                 185                 190         

Arg Ile Asp Gly Leu Leu Ile Asp Arg Val Tyr Ala Asn Tyr Tyr Leu 
        195                 200                 205             

Glu Ala Glu Gly Val Leu Asn Asp Tyr Asn Val Phe Thr Val Gly Leu 
    210                 215                 220                 

Glu Thr Glu Ala Phe Ala Val Gly Ala Arg Lys Glu Asp Thr Asn Leu 
225                 230                 235                 240 

Val Lys Lys Ile Asn Glu Ala Phe Ser Ser Leu Tyr Lys Asp Gly Lys 
                245                 250                 255     

Phe Gln Glu Ile Ser Gln Lys Trp Phe Gly Glu Asp Val Ala Thr Lys 
            260                 265                 270         

Glu Val Lys Glu Gly Gln 
        275             

<210>   3061
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3061
atgttagaat tacgaaatat caataaagtc tttggagaca aacaaatcct gtctaatttc   60
agtctaagta ttcctgaaaa gcaaatcctg gctatcgttg gaccttctgg tggaggtaag   120
acaactcttt tacgtatgct tgcaggtctt gaaaccattg attcagggca aatcttttat   180
aatggacaac ctttagagct ggatgaattg cagaagcgca atctactggg atttgtcttc   240
caagattttc aactatttcc tcatctatca gttctggaaa atttgacttt atcgcctgtg   300
aagaccatgg gaatgaagca ggaagaggct gagaagaagg cgagtggact cttggaacag   360
ttaggactag gaggacacgc agaggcctat cctttctcac tatctggtgg gcaaaagcag   420
cgggtggctt tggcgcgtgc tatgatgatt gacccagaaa tcattggcta cgatgaacca   480
acttctgccc tggatccaga attacgtttg gaagtggaga agctaatctt gcaaaatagg   540
gaacttggga tgacccagat tgtggttacc catgatttgc agtttgctga aaatatcgca   600
gatgtattat tgaaagtaga acctaaa                                       627

<210>   3062
<211>   209

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903397 (e-115)

<400>   3062
Met Leu Glu Leu Arg Asn Ile Asn Lys Val Phe Gly Asp Lys Gln Ile 
1               5                   10                  15      

Leu Ser Asn Phe Ser Leu Ser Ile Pro Glu Lys Gln Ile Leu Ala Ile 
            20                  25                  30          

Val Gly Pro Ser Gly Gly Gly Lys Thr Thr Leu Leu Arg Met Leu Ala 
        35                  40                  45              

Gly Leu Glu Thr Ile Asp Ser Gly Gln Ile Phe Tyr Asn Gly Gln Pro 
    50                  55                  60                  

Leu Glu Leu Asp Glu Leu Gln Lys Arg Asn Leu Leu Gly Phe Val Phe 
65                  70                  75                  80  

Gln Asp Phe Gln Leu Phe Pro His Leu Ser Val Leu Glu Asn Leu Thr 
                85                  90                  95      

Leu Ser Pro Val Lys Thr Met Gly Met Lys Gln Glu Glu Ala Glu Lys 
            100                 105                 110         

Lys Ala Ser Gly Leu Leu Glu Gln Leu Gly Leu Gly Gly His Ala Glu 
        115                 120                 125             

Ala Tyr Pro Phe Ser Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Leu 
    130                 135                 140                 

Ala Arg Ala Met Met Ile Asp Pro Glu Ile Ile Gly Tyr Asp Glu Pro 
145                 150                 155                 160 

Thr Ser Ala Leu Asp Pro Glu Leu Arg Leu Glu Val Glu Lys Leu Ile 
                165                 170                 175     

Leu Gln Asn Arg Glu Leu Gly Met Thr Gln Ile Val Val Thr His Asp 
            180                 185                 190         

Leu Gln Phe Ala Glu Asn Ile Ala Asp Val Leu Leu Lys Val Glu Pro 
        195                 200                 205             

Lys 
    

<210>   3063
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3063
atgtcttatt tatttgagat attaccgagt ttactgaatg gtgcgagcac gactgtacag   60
gtctttgcac tggtcttgct attttcgatt cccttgggcg ttttgattgc ctttgccttg   120
caagtccatt ggaagcccct ccattatctg attaacattt acatctgggt tatgcgagga   180
acccccttac tcttgcaact gatttttatc tattatgtgc tcccaagtat tgggattcgt   240
ttagaccgcc ttcctgcagc tattattgcc tttgttctca actatgcagc ttactttgca   300
gaaattttcc gtgggggaat tgacactatt ccaagaggac agtatgaggc cgccaaggtc   360
ttgaagttta gcccttttga cagagtgcgc tatattatct tgccccaagt gaccaagatc   420
gttcttccta gtgtctttaa tgaagttatg agtttggtca aggatacttc tttggtctat   480
gctctcggaa tttcagacct tatcttggct agtcgaacag ctgctaaccg cgatgctagt   540
ctagttccta tgttcttggc aggagccatt tatttgattt tgattgggat tgtgacaatt   600
atttccaaaa aagttgagaa gaagtatagt tattataga                          639

<210>   3064
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amino acid ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903398 (e-116)

<400>   3064
Met Ser Tyr Leu Phe Glu Ile Leu Pro Ser Leu Leu Asn Gly Ala Ser 
1               5                   10                  15      

Thr Thr Val Gln Val Phe Ala Leu Val Leu Leu Phe Ser Ile Pro Leu 
            20                  25                  30          

Gly Val Leu Ile Ala Phe Ala Leu Gln Val His Trp Lys Pro Leu His 
        35                  40                  45              

Tyr Leu Ile Asn Ile Tyr Ile Trp Val Met Arg Gly Thr Pro Leu Leu 
    50                  55                  60                  

Leu Gln Leu Ile Phe Ile Tyr Tyr Val Leu Pro Ser Ile Gly Ile Arg 
65                  70                  75                  80  

Leu Asp Arg Leu Pro Ala Ala Ile Ile Ala Phe Val Leu Asn Tyr Ala 
                85                  90                  95      

Ala Tyr Phe Ala Glu Ile Phe Arg Gly Gly Ile Asp Thr Ile Pro Arg 
            100                 105                 110         

Gly Gln Tyr Glu Ala Ala Lys Val Leu Lys Phe Ser Pro Phe Asp Arg 
        115                 120                 125             

Val Arg Tyr Ile Ile Leu Pro Gln Val Thr Lys Ile Val Leu Pro Ser 
    130                 135                 140                 

Val Phe Asn Glu Val Met Ser Leu Val Lys Asp Thr Ser Leu Val Tyr 
145                 150                 155                 160 

Ala Leu Gly Ile Ser Asp Leu Ile Leu Ala Ser Arg Thr Ala Ala Asn 
                165                 170                 175     

Arg Asp Ala Ser Leu Val Pro Met Phe Leu Ala Gly Ala Ile Tyr Leu 
            180                 185                 190         

Ile Leu Ile Gly Ile Val Thr Ile Ile Ser Lys Lys Val Glu Lys Lys 
        195                 200                 205             

Tyr Ser Tyr Tyr Arg 
    210             

<210>   3065
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3065
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattgtt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg tgggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   3066
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903941 (2.E-46)

<400>   3066
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   3067
<211>   1242
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3067
gtgaggaagt caagagtgaa caatagtcaa cagatgttac aggctttgga ggagcaagat   60
ttaactaagg ctgagcatta tttcgccaaa gctttagaaa atgattcaag tgatcttctg   120
tatgaattgg caacttatct tgaagggatt ggtttctatc ctcaggccaa ggaaatttac   180
ctgaaaattg tagaggattt tccagaggtt catcttaatc tagctgcaat tgctagcgag   240
gatggtcaaa tagaagaagc ctttacctat cttgaggaaa tccaagctga cagtgactgg   300
tatgtctcgt ctttggctct gaaggcagac ctttaccagc tggaaggttt gacagatgtg   360
gcacgtgaga aattattgga ggccttgacc tactcagagg attctctctt gatattgggt   420
ttggcagagt tggatagtga gttggaaaat taccaagcgg ctattcaagc ctatgcccag   480
ttagataatc gctcgattta tgagcaaacg ggcatttcca cctatcaacg aattggcttt   540
gcctatgctc agttagggaa atttgaaacg gctactgagt ttttagaaaa agccctggag   600
ttagaatacg atgacttaac agcttttgag ttggccagtc tttattttga tcaagaagaa   660
tatcaaaaag ccaccctcta ctttaagcag cttgatacca tttctcctga ctttgaaggc   720
tatgagtatg ggtacagtca ggctttacat aaggaacatc aagttcaaga agccctgcgt   780
atcgctaagc aaggattaga gaaaaatccc tttgaaactc gcctcttgct agctgcttca   840
caattttctt atgaattgca tgatgctagt ggtgcagaaa attatctcct tactgcaaaa   900
gaagacgctg aggatacaga agaaatcttg cttcgtttag ccactattta tctggagcag   960
gagcgttatg aggatattct agaattgcag agtgaggagc cagaaaatct tttgaccaag   1020
tggatgattg ctcgttctta tcaagaaatg gacgatttgg atactgctta tgagtattat   1080
caagagttga caggagattt gaaggacaat ccagaatttc tggaacacta tatctatctc   1140
ttgcgtgaat tgggacattt tgaagaagca aaagtccatg ctcacactta cttaaaactg   1200
gttccagatg atgtgcaaat gcaagaactg tttgagagat tg                      1242

<210>   3068
<211>   414
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   TPR domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   3068
Met Arg Lys Ser Arg Val Asn Asn Ser Gln Gln Met Leu Gln Ala Leu 
1               5                   10                  15      

Glu Glu Gln Asp Leu Thr Lys Ala Glu His Tyr Phe Ala Lys Ala Leu 
            20                  25                  30          

Glu Asn Asp Ser Ser Asp Leu Leu Tyr Glu Leu Ala Thr Tyr Leu Glu 
        35                  40                  45              


Gly Ile Gly Phe Tyr Pro Gln Ala Lys Glu Ile Tyr Leu Lys Ile Val 
    50                  55                  60                  

Glu Asp Phe Pro Glu Val His Leu Asn Leu Ala Ala Ile Ala Ser Glu 
65                  70                  75                  80  

Asp Gly Gln Ile Glu Glu Ala Phe Thr Tyr Leu Glu Glu Ile Gln Ala 
                85                  90                  95      

Asp Ser Asp Trp Tyr Val Ser Ser Leu Ala Leu Lys Ala Asp Leu Tyr 
            100                 105                 110         

Gln Leu Glu Gly Leu Thr Asp Val Ala Arg Glu Lys Leu Leu Glu Ala 
        115                 120                 125             

Leu Thr Tyr Ser Glu Asp Ser Leu Leu Ile Leu Gly Leu Ala Glu Leu 
    130                 135                 140                 

Asp Ser Glu Leu Glu Asn Tyr Gln Ala Ala Ile Gln Ala Tyr Ala Gln 
145                 150                 155                 160 

Leu Asp Asn Arg Ser Ile Tyr Glu Gln Thr Gly Ile Ser Thr Tyr Gln 
                165                 170                 175     

Arg Ile Gly Phe Ala Tyr Ala Gln Leu Gly Lys Phe Glu Thr Ala Thr 
            180                 185                 190         

Glu Phe Leu Glu Lys Ala Leu Glu Leu Glu Tyr Asp Asp Leu Thr Ala 
        195                 200                 205             

Phe Glu Leu Ala Ser Leu Tyr Phe Asp Gln Glu Glu Tyr Gln Lys Ala 
    210                 215                 220                 

Thr Leu Tyr Phe Lys Gln Leu Asp Thr Ile Ser Pro Asp Phe Glu Gly 
225                 230                 235                 240 

Tyr Glu Tyr Gly Tyr Ser Gln Ala Leu His Lys Glu His Gln Val Gln 
                245                 250                 255     

Glu Ala Leu Arg Ile Ala Lys Gln Gly Leu Glu Lys Asn Pro Phe Glu 
            260                 265                 270         

Thr Arg Leu Leu Leu Ala Ala Ser Gln Phe Ser Tyr Glu Leu His Asp 
        275                 280                 285             

Ala Ser Gly Ala Glu Asn Tyr Leu Leu Thr Ala Lys Glu Asp Ala Glu 
    290                 295                 300                 

Asp Thr Glu Glu Ile Leu Leu Arg Leu Ala Thr Ile Tyr Leu Glu Gln 
305                 310                 315                 320 

Glu Arg Tyr Glu Asp Ile Leu Glu Leu Gln Ser Glu Glu Pro Glu Asn 
                325                 330                 335     

Leu Leu Thr Lys Trp Met Ile Ala Arg Ser Tyr Gln Glu Met Asp Asp 
            340                 345                 350         

Leu Asp Thr Ala Tyr Glu Tyr Tyr Gln Glu Leu Thr Gly Asp Leu Lys 
        355                 360                 365             

Asp Asn Pro Glu Phe Leu Glu His Tyr Ile Tyr Leu Leu Arg Glu Leu 
    370                 375                 380                 

Gly His Phe Glu Glu Ala Lys Val His Ala His Thr Tyr Leu Lys Leu 
385                 390                 395                 400 

Val Pro Asp Asp Val Gln Met Gln Glu Leu Phe Glu Arg Leu 
                405                 410                 

<210>   3069
<211>   1071
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3069
ttgggactga atctttttat tttaagtaag attagttttc tattttcacc tgttttagac   60
tttttagcag ttgtgatgtt gccagtcatt ttgtctggtt tgttatatta tttgttgaat   120
cctattgttg attggatgga gaagcataag gttaatcgtg ttatagctat cactattgtc   180
tttgttatca tcgctctctt tatcatttgg ggcttggcag tcgccattcc aaatctgcaa   240
cgtcaggttt tgacctttgc aagaaacgtt cctgtttact tagaagatat agataggatt   300
gttaatggat tggtagccca gcacctgcca gatgatttca gacctcaatt agagcaagtt   360
ttgaccaatt tttctagcca ggctacagtt ttggcaagta aggtttcatc tcaggcagtc   420
aactgggtga gtgcctttat tagcggggct tctcaagtga ttgttgcctt gattatcgtt   480
cctttcatgc tcttttatct cttgcgtgat gggaaaggct tgcgtaacta tttgacccaa   540
ttcattccaa gaaaattgaa ggaacctgtt ggacaagttt tatcagatgt gaatcaacag   600
ttgtccaact atgttcgagg gcaagtgaca gtggctatta ttgtagcagt aatgtttatc   660
atcttcttca agattattgg tctacgctat gcggttacgc tgggggttac tgctggtatt   720
ttaaatctgg tcccttatct tggtagcttt ctagccatgc ttcctgctct agtattgggt   780
ttgattgctg gtccagtcat gcttttgaaa gtagtgattg tctttatcgt agaacaaact   840
attgaaggcc gttttgtctc tccattgatt ttgggaagtc aattaaacat ccaccctatt   900
aatgttctct ttgttttgtt aacttcagga tctatgtttg gtatctgggg agttttactt   960
ggtattccgg tttatgcctc tgctaaggtt gtcatttcag ccattttcga atggtataag   1020
gtagtcagtg gtctatatga attagagggt gaggaagtca agagtgaaca a            1071

<210>   3070
<211>   357
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903400 (0.E+01)

<400>   3070
Met Gly Leu Asn Leu Phe Ile Leu Ser Lys Ile Ser Phe Leu Phe Ser 
1               5                   10                  15      

Pro Val Leu Asp Phe Leu Ala Val Val Met Leu Pro Val Ile Leu Ser 
            20                  25                  30          

Gly Leu Leu Tyr Tyr Leu Leu Asn Pro Ile Val Asp Trp Met Glu Lys 
        35                  40                  45              

His Lys Val Asn Arg Val Ile Ala Ile Thr Ile Val Phe Val Ile Ile 
    50                  55                  60                  

Ala Leu Phe Ile Ile Trp Gly Leu Ala Val Ala Ile Pro Asn Leu Gln 
65                  70                  75                  80  

Arg Gln Val Leu Thr Phe Ala Arg Asn Val Pro Val Tyr Leu Glu Asp 
                85                  90                  95      

Ile Asp Arg Ile Val Asn Gly Leu Val Ala Gln His Leu Pro Asp Asp 
            100                 105                 110         

Phe Arg Pro Gln Leu Glu Gln Val Leu Thr Asn Phe Ser Ser Gln Ala 
        115                 120                 125             

Thr Val Leu Ala Ser Lys Val Ser Ser Gln Ala Val Asn Trp Val Ser 
    130                 135                 140                 

Ala Phe Ile Ser Gly Ala Ser Gln Val Ile Val Ala Leu Ile Ile Val 
145                 150                 155                 160 

Pro Phe Met Leu Phe Tyr Leu Leu Arg Asp Gly Lys Gly Leu Arg Asn 
                165                 170                 175     

Tyr Leu Thr Gln Phe Ile Pro Arg Lys Leu Lys Glu Pro Val Gly Gln 
            180                 185                 190         

Val Leu Ser Asp Val Asn Gln Gln Leu Ser Asn Tyr Val Arg Gly Gln 
        195                 200                 205             

Val Thr Val Ala Ile Ile Val Ala Val Met Phe Ile Ile Phe Phe Lys 
    210                 215                 220                 

Ile Ile Gly Leu Arg Tyr Ala Val Thr Leu Gly Val Thr Ala Gly Ile 
225                 230                 235                 240 

Leu Asn Leu Val Pro Tyr Leu Gly Ser Phe Leu Ala Met Leu Pro Ala 
                245                 250                 255     

Leu Val Leu Gly Leu Ile Ala Gly Pro Val Met Leu Leu Lys Val Val 
            260                 265                 270         

Ile Val Phe Ile Val Glu Gln Thr Ile Glu Gly Arg Phe Val Ser Pro 
        275                 280                 285             

Leu Ile Leu Gly Ser Gln Leu Asn Ile His Pro Ile Asn Val Leu Phe 
    290                 295                 300                 

Val Leu Leu Thr Ser Gly Ser Met Phe Gly Ile Trp Gly Val Leu Leu 
305                 310                 315                 320 

Gly Ile Pro Val Tyr Ala Ser Ala Lys Val Val Ile Ser Ala Ile Phe 
                325                 330                 335     

Glu Trp Tyr Lys Val Val Ser Gly Leu Tyr Glu Leu Glu Gly Glu Glu 
            340                 345                 350         

Val Lys Ser Glu Gln 
        355         

<210>   3071
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3071
ttgtttcaaa aatggtataa tgagagaaca atagaaagga agtatttatg gagcaaaaag   60
agaaacattt tagcctatct tggtttttca agtggtttt                          99

<210>   3072
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3072
Met Phe Gln Lys Trp Tyr Asn Glu Arg Thr Ile Glu Arg Lys Tyr Leu 
1               5                   10                  15      

Trp Ser Lys Lys Arg Asn Ile Leu Ala Tyr Leu Gly Phe Ser Ser Gly 
            20                  25                  30          

Phe 
    

<210>   3073
<211>   1011
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3073
atgaaagaaa ctgtttattt tggaacttat acacgtcgta cttctcaagg gatttacaag   60
gcagactttg atacagaaac tggtcagctt tcaaatctag aactttttgc agctgagcca   120
agtccaacct accttgcctt tgaccagcac caacatttat acactgttgg tagccaagac   180
gataaggggg gaattgcagc ctatcaaact gacgggactg tgttaaatca tgttgttgaa   240
gaaggagctc cccactgtta tgttgctgtc gatgaaaagc gtgatttggt ttacgcagct   300
aactatcaca agggacaagt ccttgtttat aaacgccagg aagatggtag tcttctactt   360
agtgatatgg atcaacacag tggccaaggt ccacatgaaa atcaagcttc cccccatgtt   420
cactatacag atttaacacc tgaccactat ctagtgacct gcgacttggg aactgaccaa   480
gtcatcacct atgacctcga tcaagaagga aaattatcta agctctatac ctatcacagc   540
aagccaggag caggctcacg ccatatcatt ttccataacc actataaaat cgcttatctc   600
atttgtgaac tcaatagtac tatcgaagtt ttaatctacg atggcgttgg cgaatttgaa   660
cgtatgcagg tcatttcaac tttaccggaa gcttacgaag gctttaatgg aaccgctgct   720
attcatctct ctaaagacgg taaatacctc tacgcttcta accgtggcca tgattctatc   780
gcagtatata ccatccttgc ggacggtagc ttagagttat tagaaatcgt tccaacgcat   840
ggtcagactc cacgtgattt tgatttgaca cccgaccaaa aatttctcat tgttgtccat   900
caagactctg acaatgcaac tgtctttaaa cgtaattgtg acaatggtcg tctagcagaa   960
ctctccaacg acttccatgt tcccgaagca gtctgcatcc gttttgctcc t            1011

<210>   3074
<211>   337
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903401 (0.E+01)

<400>   3074
Met Lys Glu Thr Val Tyr Phe Gly Thr Tyr Thr Arg Arg Thr Ser Gln 
1               5                   10                  15      

Gly Ile Tyr Lys Ala Asp Phe Asp Thr Glu Thr Gly Gln Leu Ser Asn 
            20                  25                  30          

Leu Glu Leu Phe Ala Ala Glu Pro Ser Pro Thr Tyr Leu Ala Phe Asp 
        35                  40                  45              

Gln His Gln His Leu Tyr Thr Val Gly Ser Gln Asp Asp Lys Gly Gly 
    50                  55                  60                  

Ile Ala Ala Tyr Gln Thr Asp Gly Thr Val Leu Asn His Val Val Glu 
65                  70                  75                  80  

Glu Gly Ala Pro His Cys Tyr Val Ala Val Asp Glu Lys Arg Asp Leu 
                85                  90                  95      

Val Tyr Ala Ala Asn Tyr His Lys Gly Gln Val Leu Val Tyr Lys Arg 
            100                 105                 110         

Gln Glu Asp Gly Ser Leu Leu Leu Ser Asp Met Asp Gln His Ser Gly 
        115                 120                 125             

Gln Gly Pro His Glu Asn Gln Ala Ser Pro His Val His Tyr Thr Asp 
    130                 135                 140                 

Leu Thr Pro Asp His Tyr Leu Val Thr Cys Asp Leu Gly Thr Asp Gln 
145                 150                 155                 160 

Val Ile Thr Tyr Asp Leu Asp Gln Glu Gly Lys Leu Ser Lys Leu Tyr 
                165                 170                 175     

Thr Tyr His Ser Lys Pro Gly Ala Gly Ser Arg His Ile Ile Phe His 
            180                 185                 190         

Asn His Tyr Lys Ile Ala Tyr Leu Ile Cys Glu Leu Asn Ser Thr Ile 
        195                 200                 205             

Glu Val Leu Ile Tyr Asp Gly Val Gly Glu Phe Glu Arg Met Gln Val 
    210                 215                 220                 

Ile Ser Thr Leu Pro Glu Ala Tyr Glu Gly Phe Asn Gly Thr Ala Ala 
225                 230                 235                 240 

Ile His Leu Ser Lys Asp Gly Lys Tyr Leu Tyr Ala Ser Asn Arg Gly 
                245                 250                 255     

His Asp Ser Ile Ala Val Tyr Thr Ile Leu Ala Asp Gly Ser Leu Glu 
            260                 265                 270         

Leu Leu Glu Ile Val Pro Thr His Gly Gln Thr Pro Arg Asp Phe Asp 
        275                 280                 285             

Leu Thr Pro Asp Gln Lys Phe Leu Ile Val Val His Gln Asp Ser Asp 
    290                 295                 300                 

Asn Ala Thr Val Phe Lys Arg Asn Cys Asp Asn Gly Arg Leu Ala Glu 
305                 310                 315                 320 

Leu Ser Asn Asp Phe His Val Pro Glu Ala Val Cys Ile Arg Phe Ala 
                325                 330                 335     

Pro 
    

<210>   3075
<211>   417
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3075
atggctcagt taactgtcca gatcgtgaca ccagatggtc tcgtctatga tcaccatgcc   60
agctatgtat cggttcgaac tctggatggt gagatgggga tcttgccacg acatgaaaat   120
atgattgcgg ttttagcagt tgatgaagta aaggtaaaac gtatcgatga taaagatcac   180
gtgaactgga ttgcagtaaa cggtggcgtt attgaaattg ccaatgatat gatcacaatc   240
gtcgctgact ctgcagaacg tgctcgtgat atcgatatca gtcgtgcaga acgtgccaaa   300
cttcgtgcag aacgtgcaat tgaagaagca caagacaaac atttgattga ccaagaacgt   360
cgtgctaaga ttgctttgca acgtgctatt aaccgtatta atgtcggaaa tagacta      417

<210>   3076
<211>   139
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP synthase F1, epsilon subunit (atpC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903402 (2.E-74)

<400>   3076
Met Ala Gln Leu Thr Val Gln Ile Val Thr Pro Asp Gly Leu Val Tyr 
1               5                   10                  15      

Asp His His Ala Ser Tyr Val Ser Val Arg Thr Leu Asp Gly Glu Met 
            20                  25                  30          

Gly Ile Leu Pro Arg His Glu Asn Met Ile Ala Val Leu Ala Val Asp 
        35                  40                  45              

Glu Val Lys Val Lys Arg Ile Asp Asp Lys Asp His Val Asn Trp Ile 
    50                  55                  60                  

Ala Val Asn Gly Gly Val Ile Glu Ile Ala Asn Asp Met Ile Thr Ile 
65                  70                  75                  80  

Val Ala Asp Ser Ala Glu Arg Ala Arg Asp Ile Asp Ile Ser Arg Ala 
                85                  90                  95      

Glu Arg Ala Lys Leu Arg Ala Glu Arg Ala Ile Glu Glu Ala Gln Asp 
            100                 105                 110         

Lys His Leu Ile Asp Gln Glu Arg Arg Ala Lys Ile Ala Leu Gln Arg 
        115                 120                 125             

Ala Ile Asn Arg Ile Asn Val Gly Asn Arg Leu 
    130                 135                 

<210>   3077
<211>   1404
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3077
atgagttcag gtaaaattgc tcaggttatc ggtcccgttg tagacgtttt gtttgcagca   60
ggggaaaaac ttcctgagat taacaatgca cttgtcgtct acaaaaatga cgaaagaaaa   120
acaaaaatcg tccttgaagt agccttggag ttaggagatg gtatggttcg tactatcgcc   180
atggaatcaa cagatgggtt gactcgtgga atggaagtat tggacacagg tcgtccaatc   240
tctgtaccag taggtaaaga aactttggga cgtgtcttca acgttttggg agataccatt   300
gacttggaag ctccttttac agaagacgca gagcgtcagc caattcataa aaaagctcca   360
acttttgatg agttgtctac ctcttctgaa atccttgaaa cagggatcaa ggttattgac   420
cttcttgccc cttaccttaa aggtggtaaa gttggacttt tcggtggtgc cggagttggt   480
aaaactgtct taatccaaga attgattcac aacattgccc aagagcacgg tggtatttca   540
gtatttgctg gtgttgggga acgtactcgt gaggggaatg acctttactg ggaaatgaaa   600
gaatcaggcg ttatcgagaa aacagccatg gtctttggtc agatgaatga gccaccagga   660
gcacgtatgc gtgttgccct tactggtttg acaatcgctg aatacttccg tgatgtggaa   720
ggccaagacg tgcttctctt tatcgataat atcttccgtt tcactcaggc tggttcagaa   780
gtatctgccc ttttgggtcg tatgccatca gccgttggtt accaaccaac acttgctacg   840
gaaatgggtc aattgcaaga acgtatcaca tcaaccaaga agggttctgt aacctctatc   900
caggctatct atgtgccagc ggatgactat actgacccag cgccagcaac agccttcgct   960
cacttggatt caacaacaaa cttggaacgt aagttggtac aattgggtat ctacccagcc   1020
gttgacccac ttgcttcaag ctcacgtgcc ttggcacctg aaatcgttgg agaagagcac   1080
tatgcagttg ctgctgaagt aaaacgtgtc cttcaacgtt accatgaatt gcaagatatc   1140
attgctatcc ttggtatgga tgagctttct gatgaagaaa agaccttggt tgctcgcgcc   1200
cgtcgtatcc agttcttctt gtcacaaaac ttcaacgttg cggaacaatt tactggtcag   1260
ccaggttctt atgttccagt tgctgaaact gtacgtggct ttaaggaaat ccttgatggt   1320
aaatacgacc acttgccaga agatgccttc cgtggtgtag gttctatcga agatgtgatt   1380
gcaaaagctg aaaaaatggg attt                                          1404

<210>   3078
<211>   468
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP synthase F1, beta subunit (atpD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903403 (0.E+01)

<400>   3078
Met Ser Ser Gly Lys Ile Ala Gln Val Ile Gly Pro Val Val Asp Val 
1               5                   10                  15      

Leu Phe Ala Ala Gly Glu Lys Leu Pro Glu Ile Asn Asn Ala Leu Val 
            20                  25                  30          

Val Tyr Lys Asn Asp Glu Arg Lys Thr Lys Ile Val Leu Glu Val Ala 
        35                  40                  45              

Leu Glu Leu Gly Asp Gly Met Val Arg Thr Ile Ala Met Glu Ser Thr 
    50                  55                  60                  

Asp Gly Leu Thr Arg Gly Met Glu Val Leu Asp Thr Gly Arg Pro Ile 
65                  70                  75                  80  

Ser Val Pro Val Gly Lys Glu Thr Leu Gly Arg Val Phe Asn Val Leu 
                85                  90                  95      

Gly Asp Thr Ile Asp Leu Glu Ala Pro Phe Thr Glu Asp Ala Glu Arg 
            100                 105                 110         

Gln Pro Ile His Lys Lys Ala Pro Thr Phe Asp Glu Leu Ser Thr Ser 
        115                 120                 125             

Ser Glu Ile Leu Glu Thr Gly Ile Lys Val Ile Asp Leu Leu Ala Pro 
    130                 135                 140                 

Tyr Leu Lys Gly Gly Lys Val Gly Leu Phe Gly Gly Ala Gly Val Gly 
145                 150                 155                 160 

Lys Thr Val Leu Ile Gln Glu Leu Ile His Asn Ile Ala Gln Glu His 
                165                 170                 175     

Gly Gly Ile Ser Val Phe Ala Gly Val Gly Glu Arg Thr Arg Glu Gly 
            180                 185                 190         

Asn Asp Leu Tyr Trp Glu Met Lys Glu Ser Gly Val Ile Glu Lys Thr 
        195                 200                 205             

Ala Met Val Phe Gly Gln Met Asn Glu Pro Pro Gly Ala Arg Met Arg 
    210                 215                 220                 

Val Ala Leu Thr Gly Leu Thr Ile Ala Glu Tyr Phe Arg Asp Val Glu 
225                 230                 235                 240 

Gly Gln Asp Val Leu Leu Phe Ile Asp Asn Ile Phe Arg Phe Thr Gln 
                245                 250                 255     

Ala Gly Ser Glu Val Ser Ala Leu Leu Gly Arg Met Pro Ser Ala Val 
            260                 265                 270         

Gly Tyr Gln Pro Thr Leu Ala Thr Glu Met Gly Gln Leu Gln Glu Arg 
        275                 280                 285             

Ile Thr Ser Thr Lys Lys Gly Ser Val Thr Ser Ile Gln Ala Ile Tyr 
    290                 295                 300                 

Val Pro Ala Asp Asp Tyr Thr Asp Pro Ala Pro Ala Thr Ala Phe Ala 
305                 310                 315                 320 

His Leu Asp Ser Thr Thr Asn Leu Glu Arg Lys Leu Val Gln Leu Gly 
                325                 330                 335     

Ile Tyr Pro Ala Val Asp Pro Leu Ala Ser Ser Ser Arg Ala Leu Ala 
            340                 345                 350         

Pro Glu Ile Val Gly Glu Glu His Tyr Ala Val Ala Ala Glu Val Lys 
        355                 360                 365             

Arg Val Leu Gln Arg Tyr His Glu Leu Gln Asp Ile Ile Ala Ile Leu 
    370                 375                 380                 

Gly Met Asp Glu Leu Ser Asp Glu Glu Lys Thr Leu Val Ala Arg Ala 
385                 390                 395                 400 

Arg Arg Ile Gln Phe Phe Leu Ser Gln Asn Phe Asn Val Ala Glu Gln 
                405                 410                 415     

Phe Thr Gly Gln Pro Gly Ser Tyr Val Pro Val Ala Glu Thr Val Arg 
            420                 425                 430         

Gly Phe Lys Glu Ile Leu Asp Gly Lys Tyr Asp His Leu Pro Glu Asp 
        435                 440                 445             

Ala Phe Arg Gly Val Gly Ser Ile Glu Asp Val Ile Ala Lys Ala Glu 
    450                 455                 460                 

Lys Met Gly Phe 
465             

<210>   3079
<211>   876
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3079
atggcagtat ctctaaatga tattaaaaca aaaatcgcct caacaaaaaa tacgagtcaa   60
atcactaatg ccatgcaaat ggtatcggct gctaagctag gtcgttctga agaagctgct   120
cgcaacttcc aagtttacgc tcagaaagtg cgtaaacttt tgacagatat ccttcatggt   180
aatggagctg gtgcttcaac taatccgatg ttgattagcc gttctgtgaa gaagacaggc   240
tatatcgtta tcacttcaga ccgcggtttg gttggaggtt ataattcctc tattttgaaa   300
gctgttatgg agttgaaaga agaataccac ccagacggta aaggttttga aatgatctgt   360
atcggtggga tgggagctga tttctttaag gctcgcggta ttcaaccact ttatgaatta   420
cgtggcttgt cagaccaacc tagctttgat caagttcgta agattatttc aaaaactgtt   480
gaaatgtacc aaaatgaact ctttgatgag ctttatgttt gctacaacca ccatgtcaat   540
acgctaacca gtcaaatgcg tgtggaacaa atgcttccga ttgttgactt ggatccaaat   600
gaagcggatg aagagtacag cttgactttt gaattggaaa ccagccgaga agaaattctg   660
gagcagttgt tgcctcagtt tgcagaaagt atgatttacg gtgccattat cgatgccaag   720
acagctgaga atgctgcggg catgacagcc atgcaaacag cgacagataa tgctaagaaa   780
gtcatcaatg atttgacaat tcagtataac cgtgccagac aggcggcgat tacacaagaa   840
attacagaaa tcgtagcagg tgctagtgcc ttagaa                             876

<210>   3080
<211>   292
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP synthase F1, gamma subunit (atpG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903404 (e-163)

<400>   3080
Met Ala Val Ser Leu Asn Asp Ile Lys Thr Lys Ile Ala Ser Thr Lys 
1               5                   10                  15      

Asn Thr Ser Gln Ile Thr Asn Ala Met Gln Met Val Ser Ala Ala Lys 
            20                  25                  30          

Leu Gly Arg Ser Glu Glu Ala Ala Arg Asn Phe Gln Val Tyr Ala Gln 
        35                  40                  45              

Lys Val Arg Lys Leu Leu Thr Asp Ile Leu His Gly Asn Gly Ala Gly 
    50                  55                  60                  

Ala Ser Thr Asn Pro Met Leu Ile Ser Arg Ser Val Lys Lys Thr Gly 
65                  70                  75                  80  

Tyr Ile Val Ile Thr Ser Asp Arg Gly Leu Val Gly Gly Tyr Asn Ser 
                85                  90                  95      

Ser Ile Leu Lys Ala Val Met Glu Leu Lys Glu Glu Tyr His Pro Asp 
            100                 105                 110         

Gly Lys Gly Phe Glu Met Ile Cys Ile Gly Gly Met Gly Ala Asp Phe 
        115                 120                 125             

Phe Lys Ala Arg Gly Ile Gln Pro Leu Tyr Glu Leu Arg Gly Leu Ser 
    130                 135                 140                 

Asp Gln Pro Ser Phe Asp Gln Val Arg Lys Ile Ile Ser Lys Thr Val 
145                 150                 155                 160 

Glu Met Tyr Gln Asn Glu Leu Phe Asp Glu Leu Tyr Val Cys Tyr Asn 
                165                 170                 175     

His His Val Asn Thr Leu Thr Ser Gln Met Arg Val Glu Gln Met Leu 
            180                 185                 190         

Pro Ile Val Asp Leu Asp Pro Asn Glu Ala Asp Glu Glu Tyr Ser Leu 
        195                 200                 205             

Thr Phe Glu Leu Glu Thr Ser Arg Glu Glu Ile Leu Glu Gln Leu Leu 
    210                 215                 220                 

Pro Gln Phe Ala Glu Ser Met Ile Tyr Gly Ala Ile Ile Asp Ala Lys 
225                 230                 235                 240 

Thr Ala Glu Asn Ala Ala Gly Met Thr Ala Met Gln Thr Ala Thr Asp 
                245                 250                 255     

Asn Ala Lys Lys Val Ile Asn Asp Leu Thr Ile Gln Tyr Asn Arg Ala 
            260                 265                 270         

Arg Gln Ala Ala Ile Thr Gln Glu Ile Thr Glu Ile Val Ala Gly Ala 
        275                 280                 285             

Ser Ala Leu Glu 
    290         

<210>   3081
<211>   1503
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3081
ttggcaatta acgcacaaga aatcagcgct ttaattaagc aacaaattga aaatttcaaa   60
cccaattttg atgtgactga aacaggtgtt gtaacctata tcggggacgg tatcgcgcgt   120
gctcacggcc ttgaaaatgt catgagtgga gagttgttga attttgaaaa cggctcttat   180
ggtatggctc aaaacttgga gtcaacagac gttggtatta tcatcctagg tgactttaca   240
gatatccgtg aaggcgatac aatccgccgt acagggaaaa tcatggaagt ccctgtaggt   300
gaaagtctga ttggtcgtgt tgtggatccg cttggtcgtc cagttgacgg tcttggagaa   360
atccacactg ataaaactcg tccagtagaa gcaccagctc ctggtgttat gcaacgtaag   420
tctgtttcag aaccattgca aactggtttg aaagctattg acgcccttgt accgattggt   480

cgtggtcaac gtgagttgat tatcggtgac cgtcagacag ggaaaacaac cattgcgatt   540
gatacaatct tgaaccaaaa agatcaagat atgatctgta tctacgtcgc gattggacaa   600
aaagaatcaa cagttcgtac gcaagtagaa acacttcgtc agtacggtgc cttggactac   660
acaatcgttg tgacagcctc tgcttcacaa ccatctccat tgctcttcct agctccttat   720
gctggggttg ctatggcgga agaatttatg tatcaaggta agcatgtttt gattgtatac   780
gatgatctat caaaacaagc ggtagcttat cgtgaactgt cgctcttgct tcgtcgtcct   840
ccaggtcgtg aagccttccc aggggatgtt ttctatctcc acagccgttt gcttgagcgc   900
tcagctaaag tttctgatga acttggtggt ggatcaatta cagccctacc atttatcgag   960
acacaagcag gagatatctc agcctatatc gcaaccaacg tgatttctat cactgatgga   1020
caaatcttcc ttggcgatgg cctcttcaat gcaggtattc gtccagccat cgatgcgggt   1080
tcatctgtat ctcgtgtagg tggttctgca caaatcaaag ccatgaagaa ggttgctggt   1140
acacttcgta tcgaccttgc ttcataccgt gagttggaag cctttactaa gtttggttct   1200
gacttggacg cagcaacaca ggctaagttg aaccgtggac gtcgtaccgt tgaggtcttg   1260
aaacaacctg ttcacaaacc attacctgtt gagaaacaag taaccattct ttatgctttg   1320
acacatggtt tcttggatac tgttccagta gatgatattg ttcgtttcga ggaagagttc   1380
catgccttct ttgatgctca acatccagag attttggaaa ccattcgtga tacaaaagac   1440
ttgccagaag aagcagtctt ggatgctgcg attacagagt ttctcaatca atctagcttc   1500
caa                                                                 1503

<210>   3082
<211>   501
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP synthase F1, alpha subunit (atpA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903405 (0.E+01)

<400>   3082
Met Ala Ile Asn Ala Gln Glu Ile Ser Ala Leu Ile Lys Gln Gln Ile 
1               5                   10                  15      

Glu Asn Phe Lys Pro Asn Phe Asp Val Thr Glu Thr Gly Val Val Thr 
            20                  25                  30          

Tyr Ile Gly Asp Gly Ile Ala Arg Ala His Gly Leu Glu Asn Val Met 
        35                  40                  45              

Ser Gly Glu Leu Leu Asn Phe Glu Asn Gly Ser Tyr Gly Met Ala Gln 
    50                  55                  60                  

Asn Leu Glu Ser Thr Asp Val Gly Ile Ile Ile Leu Gly Asp Phe Thr 
65                  70                  75                  80  

Asp Ile Arg Glu Gly Asp Thr Ile Arg Arg Thr Gly Lys Ile Met Glu 
                85                  90                  95      

Val Pro Val Gly Glu Ser Leu Ile Gly Arg Val Val Asp Pro Leu Gly 
            100                 105                 110         

Arg Pro Val Asp Gly Leu Gly Glu Ile His Thr Asp Lys Thr Arg Pro 
        115                 120                 125             

Val Glu Ala Pro Ala Pro Gly Val Met Gln Arg Lys Ser Val Ser Glu 
    130                 135                 140                 

Pro Leu Gln Thr Gly Leu Lys Ala Ile Asp Ala Leu Val Pro Ile Gly 
145                 150                 155                 160 

Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln Thr Gly Lys Thr 
                165                 170                 175     

Thr Ile Ala Ile Asp Thr Ile Leu Asn Gln Lys Asp Gln Asp Met Ile 
            180                 185                 190         

Cys Ile Tyr Val Ala Ile Gly Gln Lys Glu Ser Thr Val Arg Thr Gln 
        195                 200                 205             

Val Glu Thr Leu Arg Gln Tyr Gly Ala Leu Asp Tyr Thr Ile Val Val 
    210                 215                 220                 

Thr Ala Ser Ala Ser Gln Pro Ser Pro Leu Leu Phe Leu Ala Pro Tyr 
225                 230                 235                 240 

Ala Gly Val Ala Met Ala Glu Glu Phe Met Tyr Gln Gly Lys His Val 
                245                 250                 255     

Leu Ile Val Tyr Asp Asp Leu Ser Lys Gln Ala Val Ala Tyr Arg Glu 
            260                 265                 270         

Leu Ser Leu Leu Leu Arg Arg Pro Pro Gly Arg Glu Ala Phe Pro Gly 
        275                 280                 285             

Asp Val Phe Tyr Leu His Ser Arg Leu Leu Glu Arg Ser Ala Lys Val 
    290                 295                 300                 

Ser Asp Glu Leu Gly Gly Gly Ser Ile Thr Ala Leu Pro Phe Ile Glu 
305                 310                 315                 320 

Thr Gln Ala Gly Asp Ile Ser Ala Tyr Ile Ala Thr Asn Val Ile Ser 
                325                 330                 335     

Ile Thr Asp Gly Gln Ile Phe Leu Gly Asp Gly Leu Phe Asn Ala Gly 

            340                 345                 350         

Ile Arg Pro Ala Ile Asp Ala Gly Ser Ser Val Ser Arg Val Gly Gly 
        355                 360                 365             

Ser Ala Gln Ile Lys Ala Met Lys Lys Val Ala Gly Thr Leu Arg Ile 
    370                 375                 380                 

Asp Leu Ala Ser Tyr Arg Glu Leu Glu Ala Phe Thr Lys Phe Gly Ser 
385                 390                 395                 400 

Asp Leu Asp Ala Ala Thr Gln Ala Lys Leu Asn Arg Gly Arg Arg Thr 
                405                 410                 415     

Val Glu Val Leu Lys Gln Pro Val His Lys Pro Leu Pro Val Glu Lys 
            420                 425                 430         

Gln Val Thr Ile Leu Tyr Ala Leu Thr His Gly Phe Leu Asp Thr Val 
        435                 440                 445             

Pro Val Asp Asp Ile Val Arg Phe Glu Glu Glu Phe His Ala Phe Phe 
    450                 455                 460                 

Asp Ala Gln His Pro Glu Ile Leu Glu Thr Ile Arg Asp Thr Lys Asp 
465                 470                 475                 480 

Leu Pro Glu Glu Ala Val Leu Asp Ala Ala Ile Thr Glu Phe Leu Asn 
                485                 490                 495     

Gln Ser Ser Phe Gln 
            500     

<210>   3083
<211>   534
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3083
atggacaaga aaacagtaaa ggtaattgaa aaatacagca tgccttttgt ccaattggta   60
cttgaaaaag gagaagaaga ccgtatcttt tcagacttga ctcaaatcaa gcaagttgtt   120
gaaaaaacag gtctgccttc ttttttaaaa caagtggcag tagacgagtc ggataaggaa   180
aaaacaattg cttttttcca agattctgtg tcgcctttat tacaaaactt tatccaggtt   240
ctggcctaca atcacagagc aaatcttttt tatgatgtgc ttgtagattg cttgaaccga   300
cttgaaaaag aaacaaatcg atttgaagtg acgattacgt ctgctcatcc tctaactgat   360
gaacagaaga ctcgtttgct ccctttgatt gagaaaaaaa tgtctctgaa agtaaggagt   420
gtaaaagaac aaatcgatga aagtctcatt ggtggttttg tcatttttgc caatcacaag   480
acaattgatg tgagtattaa acaacaactt aaagttgtta aagaaaattt gaaa         534

<210>   3084
<211>   178
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP synthase F1, delta subunit (atpH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903406 (1.E-96)

<400>   3084
Met Asp Lys Lys Thr Val Lys Val Ile Glu Lys Tyr Ser Met Pro Phe 
1               5                   10                  15      

Val Gln Leu Val Leu Glu Lys Gly Glu Glu Asp Arg Ile Phe Ser Asp 
            20                  25                  30          

Leu Thr Gln Ile Lys Gln Val Val Glu Lys Thr Gly Leu Pro Ser Phe 
        35                  40                  45              

Leu Lys Gln Val Ala Val Asp Glu Ser Asp Lys Glu Lys Thr Ile Ala 
    50                  55                  60                  

Phe Phe Gln Asp Ser Val Ser Pro Leu Leu Gln Asn Phe Ile Gln Val 

65                  70                  75                  80  

Leu Ala Tyr Asn His Arg Ala Asn Leu Phe Tyr Asp Val Leu Val Asp 
                85                  90                  95      

Cys Leu Asn Arg Leu Glu Lys Glu Thr Asn Arg Phe Glu Val Thr Ile 
            100                 105                 110         

Thr Ser Ala His Pro Leu Thr Asp Glu Gln Lys Thr Arg Leu Leu Pro 
        115                 120                 125             

Leu Ile Glu Lys Lys Met Ser Leu Lys Val Arg Ser Val Lys Glu Gln 
    130                 135                 140                 

Ile Asp Glu Ser Leu Ile Gly Gly Phe Val Ile Phe Ala Asn His Lys 
145                 150                 155                 160 

Thr Ile Asp Val Ser Ile Lys Gln Gln Leu Lys Val Val Lys Glu Asn 
                165                 170                 175     

Leu Lys 
        

<210>   3085
<211>   492
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3085
atgcacgtaa cagtaggtga attaattggt aattttattt taatcactgg ctcttttatt   60
cttttgctag tcttgattaa aaaatttgca tggtctaata ttacaggcat tttcgaagaa   120
agagctgaaa aaattgcttc agatattgac agagctgaag aagcccgtca aaaagcagaa   180
gtattggctc aaaaacgcga agatgaattg gctggtagcc gtaaagaagc taagacaatc   240
attgaaaatg caaaggaaac agctgagcaa agtaaggcta atatcttagc agatgctaaa   300
ctagaagcag gacacttaaa agaaaaagcc aatcaagaaa ttgctcaaaa taaagtagaa   360
gctttacaga gtgttaaggg tgaggtcgca gatttgacca tcagcttagc tggtaaaatc   420
atctcacaaa accttgacag tcatgcccat aaagcactca ttgatcagta tatcgatcag   480
ctaggagaag ct                                                       492

<210>   3086
<211>   164
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP synthase F0, B subunit (atpF)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903407 (2.E-86)

<400>   3086
Met His Val Thr Val Gly Glu Leu Ile Gly Asn Phe Ile Leu Ile Thr 
1               5                   10                  15      

Gly Ser Phe Ile Leu Leu Leu Val Leu Ile Lys Lys Phe Ala Trp Ser 
            20                  25                  30          

Asn Ile Thr Gly Ile Phe Glu Glu Arg Ala Glu Lys Ile Ala Ser Asp 
        35                  40                  45              

Ile Asp Arg Ala Glu Glu Ala Arg Gln Lys Ala Glu Val Leu Ala Gln 
    50                  55                  60                  

Lys Arg Glu Asp Glu Leu Ala Gly Ser Arg Lys Glu Ala Lys Thr Ile 
65                  70                  75                  80  

Ile Glu Asn Ala Lys Glu Thr Ala Glu Gln Ser Lys Ala Asn Ile Leu 
                85                  90                  95      

Ala Asp Ala Lys Leu Glu Ala Gly His Leu Lys Glu Lys Ala Asn Gln 
            100                 105                 110         

Glu Ile Ala Gln Asn Lys Val Glu Ala Leu Gln Ser Val Lys Gly Glu 
        115                 120                 125             

Val Ala Asp Leu Thr Ile Ser Leu Ala Gly Lys Ile Ile Ser Gln Asn 
    130                 135                 140                 

Leu Asp Ser His Ala His Lys Ala Leu Ile Asp Gln Tyr Ile Asp Gln 
145                 150                 155                 160 

Leu Gly Glu Ala 
                

<210>   3087
<211>   714
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3087
atggaagaaa gtattaatcc aatcatctct attggtcctg ttatcttcaa tctgactatg   60
ttagccatga ctttgttgat tgtgggagtt atttttgtct ttatttattg ggcaagccgc   120
aatatgacct tgaaacccaa aggaaagcaa aatgtacttg agtatgtcta tgactttgtt   180
attggattta cagaacctaa cattggttcg cgctacatga aagattactc actctttttc   240
ctttgtttat tccttttcat ggtgattgcc aataaccttg gcttaatgac aaagcttcaa   300
acgatcgatg ggactaactg gtggagttcg ccaaccgcta atttacagta tgacttaacc   360
ttatcttttc ttgtcatttt gttgacacat atagaaagcg ttcgtcgtcg tggatttaaa   420
aaaagtataa aatcttttat gagtcctgtt tttgtcatac cgatgaatat cttggaagaa   480
tttacaaact tcttatcttt ggctttgcgg atttttggga atatctttgc aggagaggtc   540
atgacgagtt tgttacttct tctttcccac caagctattt attggtatcc agtagccttt   600
ggagctaatt tggcttggac tgcattttct gtctttattt cctgcatcca agcttatgtt   660
tttactcttt tgacatctgt gtatttaggg aataagatta atattgaaga ggaa         714

<210>   3088
<211>   238
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP synthase F0, A subunit (atpB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903408 (e-135)

<400>   3088
Met Glu Glu Ser Ile Asn Pro Ile Ile Ser Ile Gly Pro Val Ile Phe 
1               5                   10                  15      

Asn Leu Thr Met Leu Ala Met Thr Leu Leu Ile Val Gly Val Ile Phe 
            20                  25                  30          

Val Phe Ile Tyr Trp Ala Ser Arg Asn Met Thr Leu Lys Pro Lys Gly 
        35                  40                  45              

Lys Gln Asn Val Leu Glu Tyr Val Tyr Asp Phe Val Ile Gly Phe Thr 
    50                  55                  60                  

Glu Pro Asn Ile Gly Ser Arg Tyr Met Lys Asp Tyr Ser Leu Phe Phe 
65                  70                  75                  80  

Leu Cys Leu Phe Leu Phe Met Val Ile Ala Asn Asn Leu Gly Leu Met 
                85                  90                  95      

Thr Lys Leu Gln Thr Ile Asp Gly Thr Asn Trp Trp Ser Ser Pro Thr 
            100                 105                 110         

Ala Asn Leu Gln Tyr Asp Leu Thr Leu Ser Phe Leu Val Ile Leu Leu 
        115                 120                 125             

Thr His Ile Glu Ser Val Arg Arg Arg Gly Phe Lys Lys Ser Ile Lys 
    130                 135                 140                 

Ser Phe Met Ser Pro Val Phe Val Ile Pro Met Asn Ile Leu Glu Glu 
145                 150                 155                 160 

Phe Thr Asn Phe Leu Ser Leu Ala Leu Arg Ile Phe Gly Asn Ile Phe 
                165                 170                 175     

Ala Gly Glu Val Met Thr Ser Leu Leu Leu Leu Leu Ser His Gln Ala 
            180                 185                 190         

Ile Tyr Trp Tyr Pro Val Ala Phe Gly Ala Asn Leu Ala Trp Thr Ala 
        195                 200                 205             

Phe Ser Val Phe Ile Ser Cys Ile Gln Ala Tyr Val Phe Thr Leu Leu 
    210                 215                 220                 

Thr Ser Val Tyr Leu Gly Asn Lys Ile Asn Ile Glu Glu Glu 
225                 230                 235             

<210>   3089
<211>   198
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3089
atgaatttaa catttttagg cttatgtatt gcctgtatgg gcgtatctgt cggtgaaggt   60
ttattgatga atggactgtt taaatcagta gcacgccaac cagatatgct ttctgagttt   120
cgtagtttga tgtttttagg tgttgccttt attgaaggaa ctttctttgt aactcttgtc   180
ttctcattta ttatcaaa                                                 198

<210>   3090
<211>   66
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP synthase F0, C subunit (atpE)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903409 (3.E-33)

<400>   3090
Met Asn Leu Thr Phe Leu Gly Leu Cys Ile Ala Cys Met Gly Val Ser 
1               5                   10                  15      

Val Gly Glu Gly Leu Leu Met Asn Gly Leu Phe Lys Ser Val Ala Arg 
            20                  25                  30          

Gln Pro Asp Met Leu Ser Glu Phe Arg Ser Leu Met Phe Leu Gly Val 
        35                  40                  45              

Ala Phe Ile Glu Gly Thr Phe Phe Val Thr Leu Val Phe Ser Phe Ile 
    50                  55                  60                  

Ile Lys 
65      

<210>   3091
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3091
ttgtcaactt ttaaccgcta ttggaagcgt ttaataaaaa ttatttccat tttgctaaat   60
ttcaagttca agttagccat ccagaagtct tctctgggtg acttg                   105

<210>   3092
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3092
Met Ser Thr Phe Asn Arg Tyr Trp Lys Arg Leu Ile Lys Ile Ile Ser 
1               5                   10                  15      

Ile Leu Leu Asn Phe Lys Phe Lys Leu Ala Ile Gln Lys Ser Ser Leu 
            20                  25                  30          

Gly Asp Leu 
        35  

<210>   3093
<211>   153
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3093
atgactccca aagaagtcgc attcatcgaa aagtggatta acaactatcc taaaaaatgc   60
ttggactaca agtcacccag agaagacttc tggatggcta acttgaactt gaaatttagc   120
aaaatggaaa taatttttat taaacgcttc caa                                153

<210>   3094
<211>   51
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, putative

<400>   3094
Met Thr Pro Lys Glu Val Ala Phe Ile Glu Lys Trp Ile Asn Asn Tyr 
1               5                   10                  15      

Pro Lys Lys Cys Leu Asp Tyr Lys Ser Pro Arg Glu Asp Phe Trp Met 
            20                  25                  30          

Ala Asn Leu Asn Leu Lys Phe Ser Lys Met Glu Ile Ile Phe Ile Lys 
        35                  40                  45              

Arg Phe Gln 
    50      

<210>   3095
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3095
ttgaccaagg aactaaagga aaagattctc cactatcata accaaaaatt ttcgcctgaa   60
atgatggtta tggctaaagg ggttaacgtg ggaatttcaa ccatttacta ttggattcat   120
catggaaaat tggggttaag caagcaggat ttgctttacc ctagaaaagg aaaagcgctt   180
aagaaacagg ctagcaccaa ctttaaacct gctggtcaat ccatcgaaca gcggcctgaa   240
gctatcaatc ttcgcttgga gaatgggcat tatgagattg atacggttct acttacgaga   300
tcgaaaaact actgcttgat tgtcttgacg gatcgaaaga gtagacatca gatcatccga   360
ttgattccaa ataaaagtgc tgaggtggtc aatcaggctc taaaactcat cttaaaacaa   420
cacaagattc tttccatcac ggcagataat ggaacggaat tcaatcgctt gtttgatata   480
ttttctgagg agcacatcta ttatgcgcac ccctatgcct cttgggaaag gggaactaat   540
gagaatcaca acaggctcat tcgtaga                                       567

<210>   3096
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   insertion sequence IS1239 putative transposase

<400>   3096
Met Thr Lys Glu Leu Lys Glu Lys Ile Leu His Tyr His Asn Gln Lys 
1               5                   10                  15      

Phe Ser Pro Glu Met Met Val Met Ala Lys Gly Val Asn Val Gly Ile 
            20                  25                  30          

Ser Thr Ile Tyr Tyr Trp Ile His His Gly Lys Leu Gly Leu Ser Lys 
        35                  40                  45              

Gln Asp Leu Leu Tyr Pro Arg Lys Gly Lys Ala Leu Lys Lys Gln Ala 
    50                  55                  60                  

Ser Thr Asn Phe Lys Pro Ala Gly Gln Ser Ile Glu Gln Arg Pro Glu 
65                  70                  75                  80  

Ala Ile Asn Leu Arg Leu Glu Asn Gly His Tyr Glu Ile Asp Thr Val 
                85                  90                  95      

Leu Leu Thr Arg Ser Lys Asn Tyr Cys Leu Ile Val Leu Thr Asp Arg 
            100                 105                 110         

Lys Ser Arg His Gln Ile Ile Arg Leu Ile Pro Asn Lys Ser Ala Glu 
        115                 120                 125             

Val Val Asn Gln Ala Leu Lys Leu Ile Leu Lys Gln His Lys Ile Leu 
    130                 135                 140                 

Ser Ile Thr Ala Asp Asn Gly Thr Glu Phe Asn Arg Leu Phe Asp Ile 
145                 150                 155                 160 

Phe Ser Glu Glu His Ile Tyr Tyr Ala His Pro Tyr Ala Ser Trp Glu 
                165                 170                 175     

Arg Gly Thr Asn Glu Asn His Asn Arg Leu Ile Arg Arg 
            180                 185                 

<210>   3097
<211>   1004
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3097
atgcaagaca attatactac aaaagccaaa catttgacaa tcgatagccg tcgcttaatc   60
gaaagatgga aaaaagaagg aaaatcaaat agagaaattg cctctctact tggaaaagct   120
cctcaaacta tcacactgaa atcaagcgtg ggacagtccg acaatgtctt ggaaaagggc   180
gcttcaaaga ggtttattct gccgactacg ctcaacagtc ttatgaaaac aatcgcaagc   240
gctcggtcaa gaaatcaagc ttgaccaagg aactaaagga aaagattctc cactatcata   300
accaaaaatt ttcgcctgaa atgatggtta tggctaaagg ggttaacgtg ggaatttcaa   360
ccatttacta ttggattcat catggaaaat tggggttaag caagcaggat ttgctttacc   420
ctagaaaagg aaaagcgctt aagaaacagg ctagcaccaa ctttaaacct gctggtcaat   480
ccatcgaaca gcggcctgaa gctatcaatc ttcgcttgga gaatgggcat tatgagattg   540
atacggttct acttacgaga tcgaaaaact actgcttgat tgtcttgacg gatcgaaaga   600
gtagacatca gatcatccga ttgattccaa ataaaagtgc tgaggtggtc aatcaggctc   660
taaaactcat cttaaaacaa cacaagattc tttccatcac ggcagataat ggaacggaat   720
tcaatcgctt gtttgatata ttttctgagg agcacatcta ttatgcgcac ccctatgcct   780
cttgggaaag gggaactaat gagaatcaca acaggctcat tcgtagatag ttacctaagg   840
gaaccaagaa aatgactccc aaagaagtcg cattcatcga aaagtggatt aacaactatc   900
ctaaaaaatg cttggactac aagtcaccca gagaagactt ctggatggct aacttgaact   960
tgaaatttag caaaatggaa ataattttta ttaaacgctt ccaa                    1004

<210>   3098
<211>   102
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1239, transposase, putative FRAMESHIFT POINT MUTATION

<400>   3098
Met Leu Tyr Leu Leu Phe Asn His Lys His Lys Lys Gly Thr Glu Met 
1               5                   10                  15      

Gln Asp Asn Tyr Thr Thr Lys Ala Lys His Leu Thr Ile Asp Ser Arg 
            20                  25                  30          

Arg Leu Ile Glu Arg Trp Lys Lys Glu Gly Lys Ser Asn Arg Glu Ile 
        35                  40                  45              

Ala Ser Leu Leu Gly Lys Ala Pro Gln Thr Ile Thr Leu Lys Ser Ser 
    50                  55                  60                  

Val Gly Gln Ser Asp Asn Val Leu Glu Lys Gly Ala Ser Lys Arg Phe 
65                  70                  75                  80  

Ile Leu Pro Thr Thr Leu Asn Ser Leu Met Lys Thr Ile Ala Ser Ala 
                85                  90                  95      

Arg Ser Arg Asn Gln Ala 
            100         

<210>   3099
<211>   480

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3099
ttgatttcta agacattgtt agaaattaga ttaaattcct taatcgattt gcgcatgttt   60
tatttcattt cactatactt tagattggaa aataaggaat cacataaatc gcaagaaata   120
gggaatctga ttcgtgttta taaccgttca aaaagagaag aggctgaaag tgagccactt   180
aatctttatg tcgaagatga aaagggcaat ctcctggcag gtttgatagc agagactttt   240
ggaaattggc tagaaatcga gtatttgttt gtaaaagagg aactgcgagg gcaaggaatc   300
ggttcaaaac tattgcaaca ggcagaaagt gaagctaaga atcgaaattg ttgttttgcc   360
tttgtcaata cttaccagtt ccaggcaccg gacttttatc agaaacatgg ctacaaggaa   420
gttttttctt tgcaagactg tctctacatt aggcaaagat attattacca aaagaatctg   480

<210>   3100
<211>   160
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903411 (4.E-80)

<400>   3100
Met Ile Ser Lys Thr Leu Leu Glu Ile Arg Leu Asn Ser Leu Ile Asp 
1               5                   10                  15      

Leu Arg Met Phe Tyr Phe Ile Ser Leu Tyr Phe Arg Leu Glu Asn Lys 
            20                  25                  30          

Glu Ser His Lys Ser Gln Glu Ile Gly Asn Leu Ile Arg Val Tyr Asn 
        35                  40                  45              

Arg Ser Lys Arg Glu Glu Ala Glu Ser Glu Pro Leu Asn Leu Tyr Val 
    50                  55                  60                  

Glu Asp Glu Lys Gly Asn Leu Leu Ala Gly Leu Ile Ala Glu Thr Phe 
65                  70                  75                  80  

Gly Asn Trp Leu Glu Ile Glu Tyr Leu Phe Val Lys Glu Glu Leu Arg 
                85                  90                  95      

Gly Gln Gly Ile Gly Ser Lys Leu Leu Gln Gln Ala Glu Ser Glu Ala 
            100                 105                 110         

Lys Asn Arg Asn Cys Cys Phe Ala Phe Val Asn Thr Tyr Gln Phe Gln 
        115                 120                 125             

Ala Pro Asp Phe Tyr Gln Lys His Gly Tyr Lys Glu Val Phe Ser Leu 
    130                 135                 140                 

Gln Asp Cys Leu Tyr Ile Arg Gln Arg Tyr Tyr Tyr Gln Lys Asn Leu 
145                 150                 155                 160 


<210>   3101
<211>   360
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3101
gtgcttcact cactcctttt tccattttgc tactcttcga aaatctcttc aaaccacgtc   60
agcgtcgcct tgccgtatgt atggttactg actttgtcag tttcatctac aacctcaaaa   120
cagtgttttg agctaacttc gtcagtttca tctacaacct caaaactatg ttttgagctg   180
acttcgtcag tttcatctac aacctcaaaa ccatgttttg agccgacttc gtcagtttca   240
tctacaacct caaaactatg ttttgagctg acttcgtcag ttctatctac aacctcaaaa   300
cagtgttttg agcaacctgc ggctagtttc ctagtttgct ctttgatttt tattgagtat   360

<210>   3102
<211>   120
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3102
Met Leu His Ser Leu Leu Phe Pro Phe Cys Tyr Ser Ser Lys Ile Ser 
1               5                   10                  15      

Ser Asn His Val Ser Val Ala Leu Pro Tyr Val Trp Leu Leu Thr Leu 
            20                  25                  30          

Ser Val Ser Ser Thr Thr Ser Lys Gln Cys Phe Glu Leu Thr Ser Ser 
        35                  40                  45              

Val Ser Ser Thr Thr Ser Lys Leu Cys Phe Glu Leu Thr Ser Ser Val 
    50                  55                  60                  

Ser Ser Thr Thr Ser Lys Pro Cys Phe Glu Pro Thr Ser Ser Val Ser 
65                  70                  75                  80  

Ser Thr Thr Ser Lys Leu Cys Phe Glu Leu Thr Ser Ser Val Leu Ser 
                85                  90                  95      

Thr Thr Ser Lys Gln Cys Phe Glu Gln Pro Ala Ala Ser Phe Leu Val 
            100                 105                 110         

Cys Ser Leu Ile Phe Ile Glu Tyr 
        115                 120 

<210>   3103
<211>   480
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3103
atggcagaaa aaacatatcc tatgaccctt gaggaaaagg aaaaacttga aaaagaatta   60
gaagaattga aattggttcg tcgaccagaa gtggtagaac gcattaagat tgcccgttca   120
tacggtgacc tttcagaaaa cagtgagtac gaagcagcta aggatgaaca agcctttgtc   180
gaaggacaaa tctctagctt agaaacaaaa atccgctatg ctgaaatcgt caatagcgac   240
gcagttgccc aggacgaagt agcgattggt aaaacagtca ccatccaaga aattggtgag   300
gacgaagaag aagtttatat tatcgtaggt tcagctggtg cagatgcctt tgtaggtaag   360
gtttcaaatg aaagcccaat tgggcaggcc ttgattggca agaaaacagg tgatacagca   420
accattgaaa cgcctgttgg tagctatgat gtaaaaatct tgaaggttga aaaaacagcc   480

<210>   3104
<211>   160
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcription elongation factor GreA (greA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903412 (2.E-84)

<400>   3104
Met Ala Glu Lys Thr Tyr Pro Met Thr Leu Glu Glu Lys Glu Lys Leu 
1               5                   10                  15      

Glu Lys Glu Leu Glu Glu Leu Lys Leu Val Arg Arg Pro Glu Val Val 
            20                  25                  30          

Glu Arg Ile Lys Ile Ala Arg Ser Tyr Gly Asp Leu Ser Glu Asn Ser 
        35                  40                  45              

Glu Tyr Glu Ala Ala Lys Asp Glu Gln Ala Phe Val Glu Gly Gln Ile 
    50                  55                  60                  

Ser Ser Leu Glu Thr Lys Ile Arg Tyr Ala Glu Ile Val Asn Ser Asp 
65                  70                  75                  80  

Ala Val Ala Gln Asp Glu Val Ala Ile Gly Lys Thr Val Thr Ile Gln 
                85                  90                  95      

Glu Ile Gly Glu Asp Glu Glu Glu Val Tyr Ile Ile Val Gly Ser Ala 
            100                 105                 110         

Gly Ala Asp Ala Phe Val Gly Lys Val Ser Asn Glu Ser Pro Ile Gly 
        115                 120                 125             

Gln Ala Leu Ile Gly Lys Lys Thr Gly Asp Thr Ala Thr Ile Glu Thr 
    130                 135                 140                 

Pro Val Gly Ser Tyr Asp Val Lys Ile Leu Lys Val Glu Lys Thr Ala 
145                 150                 155                 160 


<210>   3105
<211>   1653
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3105
ttgagtgaaa agtcaagaga agaagagaaa ttaagcttta aagagcagat tctgagagat   60
ttagaaaaag taaaaggcta tgatgaagtt ctgaaagaag atgaggcagt agttcgcact   120
cctgcaaatg aaccttcaac tgaagaactc atggctgatt ccttgtcaac ggtagaggag   180
attatgagaa aagctcctac cgtgcctact cacccaagtc aaggtgtacc agcttctcca   240
gcagatgaga ttcaaagaga aactcctggt gttccaagtc atccaagtca agatgtacct   300
tcttctccag cggaagaaag tggatcaaga ccaggtccag gtcctgttag acctaagaaa   360
cttgaaagag aatacaatga aaccccaaca agggtagctg tttcctatac gacggcagag   420
aaaaaagcag aacaagcagg tccagaaaca cctacgcctg ctacagaaac agtggatatc   480
atcagagata catcacgtcg tagccgtaga gaaggagcaa aacccgttaa gcctaagaaa   540
gagaagaagt cacatgtgaa agcttttgtg atttcattcc ttgtattcct tgccttgctc   600
tcagcaggtg gttactttgg ttaccagtac gtgctagatt ccttattacc tatcgatgct   660
aattctaaga aatatgtgac ggttggaatt ccagaaggtt caaacgttca agaaatcggt   720
acgacgcttg aaaaagctgg tttggtaaag catggtctga tttttagttt ttatgccaag   780
tataaaaatt ataccgactt gaaagcaggt tactacaatt tgcaaaagag tatgagtaca   840
gaagacttac tcaaagagtt gcaaaaaggt ggaacagatg aaccgcaaga acctgtactt   900
gcgactttga caattccaga aggttatacc ttggatcaga ttgctcaagc tgtgggtcaa   960
ttgcaaggtg acttcaaaga gtctttgaca gcggaggctt tcttggctaa agttcaagat   1020
gagacgttta tcagtcaagc agtagcgaaa tatcctactt tactggaaag tttgcctgta   1080
aaagacagcg gtgcgcgtta tcgtttggaa ggataccttt tcccagctac atactctatc   1140
aaggaaagca caactattga gagcttgatt gatgagatgt tagctgctat ggataagaac   1200
ctatctcctt actatagtac tatcaaatct aaaaacttga ctgtcaatga gttgttgacc   1260
attgcttcct tggtcgaaaa agaaggtgcc aagacagaag atcgtaagct cattgcaggt   1320
gtattctaca atcgtttgaa tcgtgatatg ccacttcaaa gtaatattgc aatcttgtat   1380
gcccaaggaa aactggggca aaatatcagt ctagctgagg atgttgcgat tgataccaac   1440
attgattcac cttataatgt ttataaaaat gtaggtctca tgcctggtcc agtcgatagt   1500
ccaagtctgg atgcgattga gtcaagcatc aatcaaacta agagcgataa cctctacttt   1560
gtagcagatg tcacagaagg caaggtctac tatgctaaca atcaagaaga ccacgaccgc   1620
aatgtcgctg aacatgtcaa cagcaaatta aac                                1653

<210>   3106
<211>   551
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903413 (0.E+01)

<400>   3106
Met Ser Glu Lys Ser Arg Glu Glu Glu Lys Leu Ser Phe Lys Glu Gln 
1               5                   10                  15      

Ile Leu Arg Asp Leu Glu Lys Val Lys Gly Tyr Asp Glu Val Leu Lys 
            20                  25                  30          

Glu Asp Glu Ala Val Val Arg Thr Pro Ala Asn Glu Pro Ser Thr Glu 
        35                  40                  45              

Glu Leu Met Ala Asp Ser Leu Ser Thr Val Glu Glu Ile Met Arg Lys 
    50                  55                  60                  

Ala Pro Thr Val Pro Thr His Pro Ser Gln Gly Val Pro Ala Ser Pro 
65                  70                  75                  80  

Ala Asp Glu Ile Gln Arg Glu Thr Pro Gly Val Pro Ser His Pro Ser 
                85                  90                  95      

Gln Asp Val Pro Ser Ser Pro Ala Glu Glu Ser Gly Ser Arg Pro Gly 
            100                 105                 110         

Pro Gly Pro Val Arg Pro Lys Lys Leu Glu Arg Glu Tyr Asn Glu Thr 
        115                 120                 125             

Pro Thr Arg Val Ala Val Ser Tyr Thr Thr Ala Glu Lys Lys Ala Glu 
    130                 135                 140                 

Gln Ala Gly Pro Glu Thr Pro Thr Pro Ala Thr Glu Thr Val Asp Ile 
145                 150                 155                 160 

Ile Arg Asp Thr Ser Arg Arg Ser Arg Arg Glu Gly Ala Lys Pro Val 
                165                 170                 175     

Lys Pro Lys Lys Glu Lys Lys Ser His Val Lys Ala Phe Val Ile Ser 
            180                 185                 190         

Phe Leu Val Phe Leu Ala Leu Leu Ser Ala Gly Gly Tyr Phe Gly Tyr 
        195                 200                 205             


Gln Tyr Val Leu Asp Ser Leu Leu Pro Ile Asp Ala Asn Ser Lys Lys 
    210                 215                 220                 

Tyr Val Thr Val Gly Ile Pro Glu Gly Ser Asn Val Gln Glu Ile Gly 
225                 230                 235                 240 

Thr Thr Leu Glu Lys Ala Gly Leu Val Lys His Gly Leu Ile Phe Ser 
                245                 250                 255     

Phe Tyr Ala Lys Tyr Lys Asn Tyr Thr Asp Leu Lys Ala Gly Tyr Tyr 
            260                 265                 270         

Asn Leu Gln Lys Ser Met Ser Thr Glu Asp Leu Leu Lys Glu Leu Gln 
        275                 280                 285             

Lys Gly Gly Thr Asp Glu Pro Gln Glu Pro Val Leu Ala Thr Leu Thr 
    290                 295                 300                 

Ile Pro Glu Gly Tyr Thr Leu Asp Gln Ile Ala Gln Ala Val Gly Gln 
305                 310                 315                 320 

Leu Gln Gly Asp Phe Lys Glu Ser Leu Thr Ala Glu Ala Phe Leu Ala 
                325                 330                 335     

Lys Val Gln Asp Glu Thr Phe Ile Ser Gln Ala Val Ala Lys Tyr Pro 
            340                 345                 350         

Thr Leu Leu Glu Ser Leu Pro Val Lys Asp Ser Gly Ala Arg Tyr Arg 
        355                 360                 365             

Leu Glu Gly Tyr Leu Phe Pro Ala Thr Tyr Ser Ile Lys Glu Ser Thr 
    370                 375                 380                 

Thr Ile Glu Ser Leu Ile Asp Glu Met Leu Ala Ala Met Asp Lys Asn 
385                 390                 395                 400 

Leu Ser Pro Tyr Tyr Ser Thr Ile Lys Ser Lys Asn Leu Thr Val Asn 
                405                 410                 415     

Glu Leu Leu Thr Ile Ala Ser Leu Val Glu Lys Glu Gly Ala Lys Thr 
            420                 425                 430         

Glu Asp Arg Lys Leu Ile Ala Gly Val Phe Tyr Asn Arg Leu Asn Arg 
        435                 440                 445             

Asp Met Pro Leu Gln Ser Asn Ile Ala Ile Leu Tyr Ala Gln Gly Lys 
    450                 455                 460                 

Leu Gly Gln Asn Ile Ser Leu Ala Glu Asp Val Ala Ile Asp Thr Asn 
465                 470                 475                 480 

Ile Asp Ser Pro Tyr Asn Val Tyr Lys Asn Val Gly Leu Met Pro Gly 
                485                 490                 495     

Pro Val Asp Ser Pro Ser Leu Asp Ala Ile Glu Ser Ser Ile Asn Gln 
            500                 505                 510         

Thr Lys Ser Asp Asn Leu Tyr Phe Val Ala Asp Val Thr Glu Gly Lys 
        515                 520                 525             

Val Tyr Tyr Ala Asn Asn Gln Glu Asp His Asp Arg Asn Val Ala Glu 
    530                 535                 540                 

His Val Asn Ser Lys Leu Asn 
545                 550     

<210>   3107
<211>   492
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3107
atgaaaatca gacaagcaag attagaagat ttggatcgga ttgttgaact tgaatttgaa   60
aatttttcgg tcgaagaagc cattcctcct tctgtctttg aagcacattt gagagaaatt   120
cagacctctt ttctggttgc tgaaaaagaa ggaagaatca tgggttatat cgaaggacca   180
gttggcctgc accgccatct gcaagaccag tcttttacag aagaaataaa agactatagt   240
catgagcctg gtggttatat ctctgtgacc tgtctgtcta ttgccaagga ggcacaggga   300
ctcggactgg gccagaaatt gctgacagcc ttgaaagaag ttgctcttga agatgagaga   360
gatggcatta atctaacctg tcatgactat ctcatcgcct actatgaaaa acatggattt   420
gtcaacgaag gccagtccca gtcaaccttt gcaggggaaa catggtatga tatggtctgg   480
gaaatgaaaa aa                                                       492

<210>   3108
<211>   164
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903414 (1.E-93)

<400>   3108
Met Lys Ile Arg Gln Ala Arg Leu Glu Asp Leu Asp Arg Ile Val Glu 
1               5                   10                  15      

Leu Glu Phe Glu Asn Phe Ser Val Glu Glu Ala Ile Pro Pro Ser Val 
            20                  25                  30          

Phe Glu Ala His Leu Arg Glu Ile Gln Thr Ser Phe Leu Val Ala Glu 
        35                  40                  45              

Lys Glu Gly Arg Ile Met Gly Tyr Ile Glu Gly Pro Val Gly Leu His 
    50                  55                  60                  

Arg His Leu Gln Asp Gln Ser Phe Thr Glu Glu Ile Lys Asp Tyr Ser 
65                  70                  75                  80  

His Glu Pro Gly Gly Tyr Ile Ser Val Thr Cys Leu Ser Ile Ala Lys 
                85                  90                  95      

Glu Ala Gln Gly Leu Gly Leu Gly Gln Lys Leu Leu Thr Ala Leu Lys 
            100                 105                 110         

Glu Val Ala Leu Glu Asp Glu Arg Asp Gly Ile Asn Leu Thr Cys His 
        115                 120                 125             

Asp Tyr Leu Ile Ala Tyr Tyr Glu Lys His Gly Phe Val Asn Glu Gly 
    130                 135                 140                 

Gln Ser Gln Ser Thr Phe Ala Gly Glu Thr Trp Tyr Asp Met Val Trp 
145                 150                 155                 160 

Glu Met Lys Lys 
                

<210>   3109
<211>   462
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3109
atggaaattc caattaagat cattcaggca agcaagtctg atttgcctga gataggggca   60
cttcagacct cgtcttttcc agctgaaaag cagcaacttt cccatatttt agaagaaagt   120

atccgtaagt gtgcggatac ctttcttcta gctagggatg aaaatcaact tttaggctat   180
attttatcaa gtccccagtc agacaatccg caatgtctaa aagtacattc tttagtcatc   240
gagtttgacc atcagagaca gggcctggga acacttcttc ttgcagcctt gaaagaggtg   300
gcagttgagc tggattacaa agggattcgt ttggagagtc ctgatgagct gctttcctat   360
tttgaaatga acggttttgt tgatgaagaa gcaactttgc tctatgcaac tagccagggc   420
tatagtatga tttggtttaa tcccttttat ctggaggaac aa                      462

<210>   3110
<211>   154
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903415 (4.E-84)

<400>   3110
Met Glu Ile Pro Ile Lys Ile Ile Gln Ala Ser Lys Ser Asp Leu Pro 
1               5                   10                  15      

Glu Ile Gly Ala Leu Gln Thr Ser Ser Phe Pro Ala Glu Lys Gln Gln 
            20                  25                  30          

Leu Ser His Ile Leu Glu Glu Ser Ile Arg Lys Cys Ala Asp Thr Phe 
        35                  40                  45              

Leu Leu Ala Arg Asp Glu Asn Gln Leu Leu Gly Tyr Ile Leu Ser Ser 
    50                  55                  60                  

Pro Gln Ser Asp Asn Pro Gln Cys Leu Lys Val His Ser Leu Val Ile 
65                  70                  75                  80  

Glu Phe Asp His Gln Arg Gln Gly Leu Gly Thr Leu Leu Leu Ala Ala 
                85                  90                  95      

Leu Lys Glu Val Ala Val Glu Leu Asp Tyr Lys Gly Ile Arg Leu Glu 
            100                 105                 110         

Ser Pro Asp Glu Leu Leu Ser Tyr Phe Glu Met Asn Gly Phe Val Asp 
        115                 120                 125             

Glu Glu Ala Thr Leu Leu Tyr Ala Thr Ser Gln Gly Tyr Ser Met Ile 
    130                 135                 140                 

Trp Phe Asn Pro Phe Tyr Leu Glu Glu Gln 
145                 150                 

<210>   3111
<211>   1332
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3111
atgtcaaaga catatcattt tatcggaatt aagggatcag ggatgagtgc cttggccttg   60
atgttgcacc agatggggca caaggttcag ggatcagatg ttgaaaagta ctactttacc   120
caacgcggtc ttgagcaggc aggaattacc attcttcctt ttgatgaaaa aaatctagac   180
ggtgatatgg aaattatcgc tggaaatgcc tttcgtccag ataacaacgt cgaaattgcc   240
tatgcggacc aaaatggtat cagctacaaa cgttaccatg agtttctagg tagctttatg   300
cgtgactttg ttagcatggg agtagcagga gcacatggaa aaacttcaac gacaggtatg   360
ttgtctcatg tcttgtctca cattacagat accagcttct tgattggaga tgggacaggt   420
cgtggttcgg ccaatgccaa atattttgtc tttgaatctg acgaatatga gcgtcacttc   480
atgccttacc acccagaata ctctattatc accaacattg actttgacca tccagattat   540
ttcacaagtc tcgaggatgt ttttaatgcc tttaacgact atgccaaaca aatcaccaag   600
ggtctttttg tctatggtga agatgctgaa ttgcgtaaga ttacgtctga tgcaccaatt   660
tattattatg gttttgaagc tgaaggcaat gactttgtag ctagtgatct tcttcgttca   720
ataactggtt caaccttcac cgttcatttc cgtggacaaa acttggggca attccacatt   780
ccaacctttg gtcgtcacaa tatcatgaat gcgacagccg ttattggtct tctttacaca   840
gcaggatttg atttgaactt ggtgcgtgag cacttgaaaa catttgccgg tgttaaacgt   900
cgtttcactg agaaaattgt caatgataca gtgattatcg atgactttgc ccaccatcca   960
acagaaatta ttgcgacctt ggatgcggct cgtcagaaat acccaagcaa ggaaattgta   1020
gcagtctttc aaccgcatac ctttacaaga accattgcct tgttggacga ctttgcccat   1080
gctttaaacc aagcagatgc tgtttatcta gcgcaaattt atggctcggc tcgtgaagta   1140
gatcatggtg acgttaaggt agaagaccta gccaacaaaa tcaacaaaaa acaccaagtg   1200
attactgttg aaaatgtttc tccactccta gaccatgaca atgctgttta cgtctttatg   1260
ggagcaggag acatccaaac ctatgaatac tcatttgagc gtctcttgtc taacttgaca   1320
agcaatgttc aa                                                       1332

<210>   3112
<211>   444
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylmuramate--alanine ligase (murC)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903416 (0.E+01)

<400>   3112
Met Ser Lys Thr Tyr His Phe Ile Gly Ile Lys Gly Ser Gly Met Ser 
1               5                   10                  15      

Ala Leu Ala Leu Met Leu His Gln Met Gly His Lys Val Gln Gly Ser 
            20                  25                  30          

Asp Val Glu Lys Tyr Tyr Phe Thr Gln Arg Gly Leu Glu Gln Ala Gly 
        35                  40                  45              

Ile Thr Ile Leu Pro Phe Asp Glu Lys Asn Leu Asp Gly Asp Met Glu 
    50                  55                  60                  

Ile Ile Ala Gly Asn Ala Phe Arg Pro Asp Asn Asn Val Glu Ile Ala 
65                  70                  75                  80  

Tyr Ala Asp Gln Asn Gly Ile Ser Tyr Lys Arg Tyr His Glu Phe Leu 
                85                  90                  95      

Gly Ser Phe Met Arg Asp Phe Val Ser Met Gly Val Ala Gly Ala His 
            100                 105                 110         

Gly Lys Thr Ser Thr Thr Gly Met Leu Ser His Val Leu Ser His Ile 
        115                 120                 125             

Thr Asp Thr Ser Phe Leu Ile Gly Asp Gly Thr Gly Arg Gly Ser Ala 
    130                 135                 140                 

Asn Ala Lys Tyr Phe Val Phe Glu Ser Asp Glu Tyr Glu Arg His Phe 
145                 150                 155                 160 

Met Pro Tyr His Pro Glu Tyr Ser Ile Ile Thr Asn Ile Asp Phe Asp 
                165                 170                 175     

His Pro Asp Tyr Phe Thr Ser Leu Glu Asp Val Phe Asn Ala Phe Asn 
            180                 185                 190         

Asp Tyr Ala Lys Gln Ile Thr Lys Gly Leu Phe Val Tyr Gly Glu Asp 
        195                 200                 205             

Ala Glu Leu Arg Lys Ile Thr Ser Asp Ala Pro Ile Tyr Tyr Tyr Gly 
    210                 215                 220                 

Phe Glu Ala Glu Gly Asn Asp Phe Val Ala Ser Asp Leu Leu Arg Ser 
225                 230                 235                 240 

Ile Thr Gly Ser Thr Phe Thr Val His Phe Arg Gly Gln Asn Leu Gly 
                245                 250                 255     

Gln Phe His Ile Pro Thr Phe Gly Arg His Asn Ile Met Asn Ala Thr 
            260                 265                 270         

Ala Val Ile Gly Leu Leu Tyr Thr Ala Gly Phe Asp Leu Asn Leu Val 
        275                 280                 285             

Arg Glu His Leu Lys Thr Phe Ala Gly Val Lys Arg Arg Phe Thr Glu 
    290                 295                 300                 

Lys Ile Val Asn Asp Thr Val Ile Ile Asp Asp Phe Ala His His Pro 
305                 310                 315                 320 

Thr Glu Ile Ile Ala Thr Leu Asp Ala Ala Arg Gln Lys Tyr Pro Ser 
                325                 330                 335     

Lys Glu Ile Val Ala Val Phe Gln Pro His Thr Phe Thr Arg Thr Ile 
            340                 345                 350         

Ala Leu Leu Asp Asp Phe Ala His Ala Leu Asn Gln Ala Asp Ala Val 
        355                 360                 365             

Tyr Leu Ala Gln Ile Tyr Gly Ser Ala Arg Glu Val Asp His Gly Asp 
    370                 375                 380                 

Val Lys Val Glu Asp Leu Ala Asn Lys Ile Asn Lys Lys His Gln Val 
385                 390                 395                 400 

Ile Thr Val Glu Asn Val Ser Pro Leu Leu Asp His Asp Asn Ala Val 
                405                 410                 415     

Tyr Val Phe Met Gly Ala Gly Asp Ile Gln Thr Tyr Glu Tyr Ser Phe 
            420                 425                 430         

Glu Arg Leu Leu Ser Asn Leu Thr Ser Asn Val Gln 
        435                 440                 

<210>   3113
<211>   615
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3113
atgaaacaag aacgatttcc attggtgtca gatgacgagg tcatgttgac tgaaatgcca   60
gtcatgaatc tctatgatga gtctgatctg atcagtaata tcaagggtga gtatcgagat   120
aaaaattatt tagaatgggc tcctattgct gaagaaaaac cagtaaaacc gattgaaaag   180
caagtcgaaa aacctaaaaa ggctccttta ggggttaaaa aagaaggaaa gagctatgcg   240
gaggtggcgc gtgaagaagc gcgtgcggac ttgaaaaaga aacgctctgc taactaccta   300
actcaggatt tcagccttgc gagacgtcat tctcagccca gtctagttag acagggcaat   360
caaccgacag ctcctttcca aaaggaaaat cctggtgaat ttgtcaaata tagccaaaaa   420
ttgacccagt ctcattatat cttggcggaa gaagttcatt ctatccctac caagaatgaa   480
gaagtgtcag cacctgctcc aaagaaaaac aattatgatt ttctaaagaa gagccaaatc   540
tacaataaaa aaagtaaaca aacagaacaa gaacgtcggg ttgcccaaga gttgaatctg   600
accagaatga cagaa                                                    615

<210>   3114
<211>   205
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903417 (e-116)

<400>   3114
Met Lys Gln Glu Arg Phe Pro Leu Val Ser Asp Asp Glu Val Met Leu 
1               5                   10                  15      

Thr Glu Met Pro Val Met Asn Leu Tyr Asp Glu Ser Asp Leu Ile Ser 
            20                  25                  30          

Asn Ile Lys Gly Glu Tyr Arg Asp Lys Asn Tyr Leu Glu Trp Ala Pro 
        35                  40                  45              

Ile Ala Glu Glu Lys Pro Val Lys Pro Ile Glu Lys Gln Val Glu Lys 
    50                  55                  60                  

Pro Lys Lys Ala Pro Leu Gly Val Lys Lys Glu Gly Lys Ser Tyr Ala 
65                  70                  75                  80  


Glu Val Ala Arg Glu Glu Ala Arg Ala Asp Leu Lys Lys Lys Arg Ser 
                85                  90                  95      

Ala Asn Tyr Leu Thr Gln Asp Phe Ser Leu Ala Arg Arg His Ser Gln 
            100                 105                 110         

Pro Ser Leu Val Arg Gln Gly Asn Gln Pro Thr Ala Pro Phe Gln Lys 
        115                 120                 125             

Glu Asn Pro Gly Glu Phe Val Lys Tyr Ser Gln Lys Leu Thr Gln Ser 
    130                 135                 140                 

His Tyr Ile Leu Ala Glu Glu Val His Ser Ile Pro Thr Lys Asn Glu 
145                 150                 155                 160 

Glu Val Ser Ala Pro Ala Pro Lys Lys Asn Asn Tyr Asp Phe Leu Lys 
                165                 170                 175     

Lys Ser Gln Ile Tyr Asn Lys Lys Ser Lys Gln Thr Glu Gln Glu Arg 
            180                 185                 190         

Arg Val Ala Gln Glu Leu Asn Leu Thr Arg Met Thr Glu 
        195                 200                 205 

<210>   3115
<211>   3096
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3115
atggctaaat tgattccggg gaaaattcgt atcgaaggtg ttgcccttta tgaaactggt   60
aaggttgata tcatcaagga aaagaacaat cggctctacg ctcgcgttgc agaagaagaa   120
ctgcgctata gtttagagga tgatttggtt ttttgtgcct gtgatttttt tcaaaagagg   180
ggctactgtg tgcatttggc agcgctagag cattttctga aaaatgatga gcgtggtcag   240
gaaatcttgt ggagtctgga agaaggtcat gaagaaaaag aggctgttga aaccaaggtg   300
accttgggtg gcaagttttt ggatcgaatt ttatctccaa aatcagaatg cgcctatgag   360
ttatcagctg tgggtcaggt ggaagcagga accaatcata tcttgtggac tctgagaatc   420
ggccaaatca atagccaaaa atactatgtc attcgggata ttccactttt tttaaggatt   480
gtcgagcaga gaaagtcgta tatgattggc aagatttatg aggagtctct ttcttgggaa   540
gcctttgatg atgccagcca agaacttttg actttcttgc acggactaac ggaggaaggg   600
ctggttccag acctcttttt ccaaaaccaa ggtcggcacc tctttttccc tctgaccttt   660
tttgagcagg gtgtgaattt actgatggcc ttgccccatt ttcaatttga ccatcaagtg   720
gatagctacc aaaccctgct ttttcaggat atgcatgctg atgccaatct atttgccttt   780
acagtaacag aatactcgga ttattttgaa atggaaatca gtgagagtcc tagggtcaat   840
gtcttttatc agggagcagt acttttccat aaaggtcagg tttatttttt aacagaccag   900
cagatgcgtc ttctcaagga aattaaagcg ttacctgtgg gtcaacaagg aaagaaatac   960
ctgcaatttg atagcagtga tcgagacaaa ttggcctcct gtctgactct ttttatccag   1020
atgggcaccg tttcagctcc agaacgtcta caaatcaaaa cttttgcgcc ctctttttac   1080
tttgacaggg aagaagataa tcggattcgt ttagaaattc agtttgatta tggaaataga   1140
caggtatcta gccgacaaga gctagaagaa ttaccctttt caagtgacgc agacttagaa   1200
gaaagaattt tccaagtctg tttggctgcg ggctttgagg ccgattttca atcttggcgt   1260
caggccttaa aagcggagtc tgtctatcat ttttttcatg atatcattcc agtctttgaa   1320
aaactcgggc atgttgacct atcagataaa ctagaagagc tttatagcct agcgagtcct   1380
caggtgcaga ttgcctccaa gggaggtctc ttggaaatcc agtttgattt tcaaaatatt   1440
gtccaggagg aaatcgacca agccatgcag gccttggttg ccaatcagga tttttatatt   1500
gattcgtcta atcaagttta ctttttcgat gaagaaacca agaaaattcg ccaaaatcta   1560
caggaactgg ggcaatttga attaaaagat gggaccttgc aggctcggaa atccttggcc   1620
tacagtttag ctcatctctt tgaagggcga gaccgtgttt ctttttcaca agaattccag   1680
aatctggccc aggatttgac gcatccagag gactttcctt tgcaagcaac tcaggtcaag   1740
gctgacttgc gagattatca ggaaaaggga attggctggt tgcagatgct ccatcattat   1800
ggttttggtg ggattttggc tgatgatatg ggacttggga aaacccttca gaccattgct   1860
tttttgacta gtcaagtgac aaaagaaagt cgggttttga ttctcgctcc gtcgggtttg   1920
atttacaact gggcagatga gtttcagaaa tttgctccac agttggatgt gactgttgtt   1980
catggtttga aagcaagtcg tgaggagatt cttgccgaga gccatcaaat ctatgtgact   2040
agctatgcca ccttccgtca ggacagtgag ttttatcaag ggatggcctt tgacttcctt   2100
ttcttagatg aggctcaggt catgaaaaat gcccagacca agattgccca gaccttgaga   2160
caatttgtgg tgccgtcggt ctttgccttg tcaggaactc cgattgaaaa ccatctgggt   2220
gagttgtggt ctattttcca aatcgtcatg cctggacttt tgccaagcaa gaaagaattt   2280
atgaaattgc cagcagagcg agtggctcag tttatcaagc ctttcgtgat gcgacgcaag   2340
aaagaagaag ttctgactga attgccagac ttgattgagg tggtttataa aaatgaactg   2400
gaagaccagc aaaaggctat ttaccttgcc cagttacaac agatgcgaga ccatctggct   2460
caagtgtcag aacaggaatt tcagcgaagt cgtgtggaaa ttttatctgg tttgatgcgc   2520
ttgcgtcaaa tatgtgacac tcctgccctg tttatggaag attatcaggg agccagcggc   2580
aaactagata gtctccgaga cctactggta caggtggcag acggcggaca ccgtgtcttg   2640
attttctctc agttcaaggg aatgttggaa aaaattgaac aagaactgcc agacttgggc   2700
ctgacttcct ttaaaattac gggttcaacc ccagccaagg aaagacaaga catgaccaag   2760
gcctttaacc aaggagaaag agatgccttt ctgatttccc tcaaggctgg tggggtcggt   2820
ctgaacctga caggtgcaga tacagtgatc ttggttgacc tttggtggaa tcctgcggtg   2880
gaagcgcaag ccattggccg tgcccatcgg atgggtcagg aagaaacggt tgaggtctat   2940
cgcttggtga ccaagggaac cattgaagaa aaaattcagg aactccaaga acaaaagaaa   3000
catctggtgt cacaagtatt ggacggcaca gagtcacgtg gtagtctgac cctagcagaa   3060
attagagaaa ttttgggaat ttctgaagcc agcact                             3096

<210>   3116
<211>   1032
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Snf2 family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903418 (0.E+01)

<400>   3116
Met Ala Lys Leu Ile Pro Gly Lys Ile Arg Ile Glu Gly Val Ala Leu 
1               5                   10                  15      

Tyr Glu Thr Gly Lys Val Asp Ile Ile Lys Glu Lys Asn Asn Arg Leu 
            20                  25                  30          

Tyr Ala Arg Val Ala Glu Glu Glu Leu Arg Tyr Ser Leu Glu Asp Asp 
        35                  40                  45              

Leu Val Phe Cys Ala Cys Asp Phe Phe Gln Lys Arg Gly Tyr Cys Val 
    50                  55                  60                  

His Leu Ala Ala Leu Glu His Phe Leu Lys Asn Asp Glu Arg Gly Gln 
65                  70                  75                  80  

Glu Ile Leu Trp Ser Leu Glu Glu Gly His Glu Glu Lys Glu Ala Val 
                85                  90                  95      

Glu Thr Lys Val Thr Leu Gly Gly Lys Phe Leu Asp Arg Ile Leu Ser 
            100                 105                 110         

Pro Lys Ser Glu Cys Ala Tyr Glu Leu Ser Ala Val Gly Gln Val Glu 
        115                 120                 125             

Ala Gly Thr Asn His Ile Leu Trp Thr Leu Arg Ile Gly Gln Ile Asn 
    130                 135                 140                 

Ser Gln Lys Tyr Tyr Val Ile Arg Asp Ile Pro Leu Phe Leu Arg Ile 
145                 150                 155                 160 

Val Glu Gln Arg Lys Ser Tyr Met Ile Gly Lys Ile Tyr Glu Glu Ser 
                165                 170                 175     

Leu Ser Trp Glu Ala Phe Asp Asp Ala Ser Gln Glu Leu Leu Thr Phe 
            180                 185                 190         

Leu His Gly Leu Thr Glu Glu Gly Leu Val Pro Asp Leu Phe Phe Gln 
        195                 200                 205             

Asn Gln Gly Arg His Leu Phe Phe Pro Leu Thr Phe Phe Glu Gln Gly 
    210                 215                 220                 

Val Asn Leu Leu Met Ala Leu Pro His Phe Gln Phe Asp His Gln Val 
225                 230                 235                 240 

Asp Ser Tyr Gln Thr Leu Leu Phe Gln Asp Met His Ala Asp Ala Asn 
                245                 250                 255     

Leu Phe Ala Phe Thr Val Thr Glu Tyr Ser Asp Tyr Phe Glu Met Glu 
            260                 265                 270         

Ile Ser Glu Ser Pro Arg Val Asn Val Phe Tyr Gln Gly Ala Val Leu 
        275                 280                 285             

Phe His Lys Gly Gln Val Tyr Phe Leu Thr Asp Gln Gln Met Arg Leu 
    290                 295                 300                 

Leu Lys Glu Ile Lys Ala Leu Pro Val Gly Gln Gln Gly Lys Lys Tyr 
305                 310                 315                 320 

Leu Gln Phe Asp Ser Ser Asp Arg Asp Lys Leu Ala Ser Cys Leu Thr 
                325                 330                 335     

Leu Phe Ile Gln Met Gly Thr Val Ser Ala Pro Glu Arg Leu Gln Ile 
            340                 345                 350         

Lys Thr Phe Ala Pro Ser Phe Tyr Phe Asp Arg Glu Glu Asp Asn Arg 
        355                 360                 365             

Ile Arg Leu Glu Ile Gln Phe Asp Tyr Gly Asn Arg Gln Val Ser Ser 
    370                 375                 380                 

Arg Gln Glu Leu Glu Glu Leu Pro Phe Ser Ser Asp Ala Asp Leu Glu 
385                 390                 395                 400 

Glu Arg Ile Phe Gln Val Cys Leu Ala Ala Gly Phe Glu Ala Asp Phe 
                405                 410                 415     

Gln Ser Trp Arg Gln Ala Leu Lys Ala Glu Ser Val Tyr His Phe Phe 
            420                 425                 430         

His Asp Ile Ile Pro Val Phe Glu Lys Leu Gly His Val Asp Leu Ser 
        435                 440                 445             

Asp Lys Leu Glu Glu Leu Tyr Ser Leu Ala Ser Pro Gln Val Gln Ile 
    450                 455                 460                 

Ala Ser Lys Gly Gly Leu Leu Glu Ile Gln Phe Asp Phe Gln Asn Ile 
465                 470                 475                 480 

Val Gln Glu Glu Ile Asp Gln Ala Met Gln Ala Leu Val Ala Asn Gln 
                485                 490                 495     

Asp Phe Tyr Ile Asp Ser Ser Asn Gln Val Tyr Phe Phe Asp Glu Glu 
            500                 505                 510         

Thr Lys Lys Ile Arg Gln Asn Leu Gln Glu Leu Gly Gln Phe Glu Leu 
        515                 520                 525             

Lys Asp Gly Thr Leu Gln Ala Arg Lys Ser Leu Ala Tyr Ser Leu Ala 
    530                 535                 540                 

His Leu Phe Glu Gly Arg Asp Arg Val Ser Phe Ser Gln Glu Phe Gln 
545                 550                 555                 560 

Asn Leu Ala Gln Asp Leu Thr His Pro Glu Asp Phe Pro Leu Gln Ala 
                565                 570                 575     

Thr Gln Val Lys Ala Asp Leu Arg Asp Tyr Gln Glu Lys Gly Ile Gly 
            580                 585                 590         

Trp Leu Gln Met Leu His His Tyr Gly Phe Gly Gly Ile Leu Ala Asp 
        595                 600                 605             

Asp Met Gly Leu Gly Lys Thr Leu Gln Thr Ile Ala Phe Leu Thr Ser 
    610                 615                 620                 

Gln Val Thr Lys Glu Ser Arg Val Leu Ile Leu Ala Pro Ser Gly Leu 
625                 630                 635                 640 

Ile Tyr Asn Trp Ala Asp Glu Phe Gln Lys Phe Ala Pro Gln Leu Asp 
                645                 650                 655     

Val Thr Val Val His Gly Leu Lys Ala Ser Arg Glu Glu Ile Leu Ala 
            660                 665                 670         

Glu Ser His Gln Ile Tyr Val Thr Ser Tyr Ala Thr Phe Arg Gln Asp 
        675                 680                 685             

Ser Glu Phe Tyr Gln Gly Met Ala Phe Asp Phe Leu Phe Leu Asp Glu 
    690                 695                 700                 

Ala Gln Val Met Lys Asn Ala Gln Thr Lys Ile Ala Gln Thr Leu Arg 
705                 710                 715                 720 

Gln Phe Val Val Pro Ser Val Phe Ala Leu Ser Gly Thr Pro Ile Glu 
                725                 730                 735     

Asn His Leu Gly Glu Leu Trp Ser Ile Phe Gln Ile Val Met Pro Gly 
            740                 745                 750         

Leu Leu Pro Ser Lys Lys Glu Phe Met Lys Leu Pro Ala Glu Arg Val 
        755                 760                 765             

Ala Gln Phe Ile Lys Pro Phe Val Met Arg Arg Lys Lys Glu Glu Val 
    770                 775                 780                 

Leu Thr Glu Leu Pro Asp Leu Ile Glu Val Val Tyr Lys Asn Glu Leu 
785                 790                 795                 800 

Glu Asp Gln Gln Lys Ala Ile Tyr Leu Ala Gln Leu Gln Gln Met Arg 
                805                 810                 815     

Asp His Leu Ala Gln Val Ser Glu Gln Glu Phe Gln Arg Ser Arg Val 
            820                 825                 830         

Glu Ile Leu Ser Gly Leu Met Arg Leu Arg Gln Ile Cys Asp Thr Pro 
        835                 840                 845             

Ala Leu Phe Met Glu Asp Tyr Gln Gly Ala Ser Gly Lys Leu Asp Ser 
    850                 855                 860                 

Leu Arg Asp Leu Leu Val Gln Val Ala Asp Gly Gly His Arg Val Leu 
865                 870                 875                 880 

Ile Phe Ser Gln Phe Lys Gly Met Leu Glu Lys Ile Glu Gln Glu Leu 
                885                 890                 895     

Pro Asp Leu Gly Leu Thr Ser Phe Lys Ile Thr Gly Ser Thr Pro Ala 
            900                 905                 910         

Lys Glu Arg Gln Asp Met Thr Lys Ala Phe Asn Gln Gly Glu Arg Asp 
        915                 920                 925             

Ala Phe Leu Ile Ser Leu Lys Ala Gly Gly Val Gly Leu Asn Leu Thr 
    930                 935                 940                 

Gly Ala Asp Thr Val Ile Leu Val Asp Leu Trp Trp Asn Pro Ala Val 
945                 950                 955                 960 

Glu Ala Gln Ala Ile Gly Arg Ala His Arg Met Gly Gln Glu Glu Thr 
                965                 970                 975     

Val Glu Val Tyr Arg Leu Val Thr Lys Gly Thr Ile Glu Glu Lys Ile 
            980                 985                 990         

Gln Glu Leu Gln Glu Gln Lys Lys His Leu Val Ser Gln Val Leu Asp 
        995                 1000                1005            

Gly Thr Glu Ser Arg Gly Ser Leu Thr Leu Ala Glu Ile Arg Glu Ile 
    1010                1015                1020                

Leu Gly Ile Ser Glu Ala Ser Thr 
1025                1030        

<210>   3117
<211>   1164
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   3117
atgggaaaat atgattttac aagcctgccc aaccgtttag ggcaccatac ctataaatgg   60
aaagaaacag aaacggatag tgaagttcta ccagcttgga tagcggatat ggactttgtg   120
gtcttgcctg aaatccgcca agccgtgcaa acttacgcag accaactggt ttatggttat   180
acctatgcca gtgaagactt aattaaggaa gttcaaaagt gggaagctac acaatacggt   240
tacaactttg acaaagaggc tcttgtcttt atcgagggtg tggtaccagc catctcaaca   300
gctattcaaa cctttacaaa agaaggcgag gcggttttaa ttaacacgcc tgtctaccca   360
ccctttgctc gcagtgtcaa gttgaataat cgtagattga ttactaattc cttagtggaa   420
aaggatagtc tgtttgagat tgactttgac caacttgaaa aggatttggt ggaagaggag   480
gttaaactct atgttctttg caaccctcac aatcctggtg gacgtgtttg ggaaaaagaa   540
gtgttggaga agattggcca actctgccaa aaacacggtg ttttgttagt ttcggatgag   600
attcaccaag atttgaccct ctttggtcac aaacaccagt ctttcaatac catcaatcct   660
gccttcaaaa attttgctat cgtcttgagc agtgccacta aaacatttaa tattgctgga   720
acaaaaaatt cctatgcagt cattgaaaat cctaagttga gactggcttt ccagaaacgc   780
ctgttggcca ataatcagca tgaaatttca ggcttgggtt atttggcgac agaagctgcc   840
tatcgatacg gtaaagattg gctagaggaa ctcaagcaag tctttgaaga ccacatcaat   900
tatgtgatgg atctatttgg aaaagagact aaaatcaagg tcatgaaacc gcaaggtacc   960
tacttgattt ggcttgactt ttcagcttat gacctgactg atgaaacatt gcaagagttg   1020
ttgagaaatg aagccaaggt tatcctcaac cgtggtttgg attttggaga ggaaggaagt   1080
ctccatgccc gcatcaatat agctatgccc aaatctctgt tgcaagaagt ctgtcagcgg   1140
attgtggcta cttttgccaa acgt                                          1164

<210>   3118
<211>   388
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aminotransferase, class II
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903419 (0.E+01)

<400>   3118
Met Gly Lys Tyr Asp Phe Thr Ser Leu Pro Asn Arg Leu Gly His His 
1               5                   10                  15      

Thr Tyr Lys Trp Lys Glu Thr Glu Thr Asp Ser Glu Val Leu Pro Ala 
            20                  25                  30          

Trp Ile Ala Asp Met Asp Phe Val Val Leu Pro Glu Ile Arg Gln Ala 
        35                  40                  45              

Val Gln Thr Tyr Ala Asp Gln Leu Val Tyr Gly Tyr Thr Tyr Ala Ser 
    50                  55                  60                  

Glu Asp Leu Ile Lys Glu Val Gln Lys Trp Glu Ala Thr Gln Tyr Gly 
65                  70                  75                  80  

Tyr Asn Phe Asp Lys Glu Ala Leu Val Phe Ile Glu Gly Val Val Pro 
                85                  90                  95      

Ala Ile Ser Thr Ala Ile Gln Thr Phe Thr Lys Glu Gly Glu Ala Val 
            100                 105                 110         

Leu Ile Asn Thr Pro Val Tyr Pro Pro Phe Ala Arg Ser Val Lys Leu 
        115                 120                 125             

Asn Asn Arg Arg Leu Ile Thr Asn Ser Leu Val Glu Lys Asp Ser Leu 
    130                 135                 140                 

Phe Glu Ile Asp Phe Asp Gln Leu Glu Lys Asp Leu Val Glu Glu Glu 
145                 150                 155                 160 

Val Lys Leu Tyr Val Leu Cys Asn Pro His Asn Pro Gly Gly Arg Val 
                165                 170                 175     

Trp Glu Lys Glu Val Leu Glu Lys Ile Gly Gln Leu Cys Gln Lys His 
            180                 185                 190         

Gly Val Leu Leu Val Ser Asp Glu Ile His Gln Asp Leu Thr Leu Phe 
        195                 200                 205             

Gly His Lys His Gln Ser Phe Asn Thr Ile Asn Pro Ala Phe Lys Asn 
    210                 215                 220                 

Phe Ala Ile Val Leu Ser Ser Ala Thr Lys Thr Phe Asn Ile Ala Gly 
225                 230                 235                 240 

Thr Lys Asn Ser Tyr Ala Val Ile Glu Asn Pro Lys Leu Arg Leu Ala 
                245                 250                 255     

Phe Gln Lys Arg Leu Leu Ala Asn Asn Gln His Glu Ile Ser Gly Leu 
            260                 265                 270         

Gly Tyr Leu Ala Thr Glu Ala Ala Tyr Arg Tyr Gly Lys Asp Trp Leu 
        275                 280                 285             

Glu Glu Leu Lys Gln Val Phe Glu Asp His Ile Asn Tyr Val Met Asp 
    290                 295                 300                 

Leu Phe Gly Lys Glu Thr Lys Ile Lys Val Met Lys Pro Gln Gly Thr 
305                 310                 315                 320 

Tyr Leu Ile Trp Leu Asp Phe Ser Ala Tyr Asp Leu Thr Asp Glu Thr 
                325                 330                 335     

Leu Gln Glu Leu Leu Arg Asn Glu Ala Lys Val Ile Leu Asn Arg Gly 
            340                 345                 350         

Leu Asp Phe Gly Glu Glu Gly Ser Leu His Ala Arg Ile Asn Ile Ala 
        355                 360                 365             

Met Pro Lys Ser Leu Leu Gln Glu Val Cys Gln Arg Ile Val Ala Thr 
    370                 375                 380                 

Phe Ala Lys Arg 
385             

<210>   3119
<211>   1092
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3119
atgagcaagg aattacacat taacacaatt ttagcacaag cagggatcaa gtctgatgag   60
gcaacaggtg ctttggtgac accacttcat ttttcaacga cctatcagca tccagagttt   120
ggtcgatcta ctgggtttga ctatacgcgc actaaaaatc caactcgtag taaggctgag   180
gaagtcttgg cggctattga gtcagcagac tatgccctag cgactagctc agggatgtca   240
gctattgtac tggcctttag cgtctttcca gtaggaagta aggtcttggc agtgcgtgat   300
ctttacggtg gttcttttcg ctggtttaac caagtggagc aggaaggtca tttccatttt   360
acctatgcca atacagaaga agagttgatt gccgagttag aaaaggatgt ggatgttctc   420
tatatcgaaa ccccaaccaa tcccttgatg ttggaatttg atatcgaaaa actagcaaaa   480
ttggctcatg ctaagggtgc caaagtggtg gtggacaata ccttctatag ccctatctac   540
caacgtccga ttgaagatgg agcagatatc gttctccatt cagcaaccaa gtatctagca   600
ggccacaatg atgtcttggc tggagtggtt gtgaccaata gtttagaact atacgagaag   660
cttttttaca atcttaatac aacaggggca gtcttgtctc catttgacag ctaccagttg   720
cttcgtggtc tcaagacctt gtctcttcgt atggagcgct caacagctaa cgcccaagaa   780
gtggttgcct ttttgaagga ttctccagca gttaaggaag ttctctacac tggtcgtgga   840
ggcatgattt cctttaaagt agccgatgaa acacgcattc ctcatatttt gaacagtctc   900
aaggtcttct cttttgcgga aagtttgggt ggagtggaaa gtcttattac ttatccaacg   960
actcaaactc atgctgatat tccagcagag gtacgccatt cttatggttt gacagatgac   1020
ctcttgcgtt tgtctattgg gattgaggat gctagagatt tgattgcaga tttgcgccaa   1080
gccatagaag ga                                                       1092

<210>   3120
<211>   364
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transulfuration enzyme family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903420 (0.E+01)

<400>   3120
Met Ser Lys Glu Leu His Ile Asn Thr Ile Leu Ala Gln Ala Gly Ile 
1               5                   10                  15      

Lys Ser Asp Glu Ala Thr Gly Ala Leu Val Thr Pro Leu His Phe Ser 
            20                  25                  30          

Thr Thr Tyr Gln His Pro Glu Phe Gly Arg Ser Thr Gly Phe Asp Tyr 
        35                  40                  45              

Thr Arg Thr Lys Asn Pro Thr Arg Ser Lys Ala Glu Glu Val Leu Ala 
    50                  55                  60                  

Ala Ile Glu Ser Ala Asp Tyr Ala Leu Ala Thr Ser Ser Gly Met Ser 
65                  70                  75                  80  


Ala Ile Val Leu Ala Phe Ser Val Phe Pro Val Gly Ser Lys Val Leu 
                85                  90                  95      

Ala Val Arg Asp Leu Tyr Gly Gly Ser Phe Arg Trp Phe Asn Gln Val 
            100                 105                 110         

Glu Gln Glu Gly His Phe His Phe Thr Tyr Ala Asn Thr Glu Glu Glu 
        115                 120                 125             

Leu Ile Ala Glu Leu Glu Lys Asp Val Asp Val Leu Tyr Ile Glu Thr 
    130                 135                 140                 

Pro Thr Asn Pro Leu Met Leu Glu Phe Asp Ile Glu Lys Leu Ala Lys 
145                 150                 155                 160 

Leu Ala His Ala Lys Gly Ala Lys Val Val Val Asp Asn Thr Phe Tyr 
                165                 170                 175     

Ser Pro Ile Tyr Gln Arg Pro Ile Glu Asp Gly Ala Asp Ile Val Leu 
            180                 185                 190         

His Ser Ala Thr Lys Tyr Leu Ala Gly His Asn Asp Val Leu Ala Gly 
        195                 200                 205             

Val Val Val Thr Asn Ser Leu Glu Leu Tyr Glu Lys Leu Phe Tyr Asn 
    210                 215                 220                 

Leu Asn Thr Thr Gly Ala Val Leu Ser Pro Phe Asp Ser Tyr Gln Leu 
225                 230                 235                 240 

Leu Arg Gly Leu Lys Thr Leu Ser Leu Arg Met Glu Arg Ser Thr Ala 
                245                 250                 255     

Asn Ala Gln Glu Val Val Ala Phe Leu Lys Asp Ser Pro Ala Val Lys 
            260                 265                 270         

Glu Val Leu Tyr Thr Gly Arg Gly Gly Met Ile Ser Phe Lys Val Ala 
        275                 280                 285             

Asp Glu Thr Arg Ile Pro His Ile Leu Asn Ser Leu Lys Val Phe Ser 
    290                 295                 300                 

Phe Ala Glu Ser Leu Gly Gly Val Glu Ser Leu Ile Thr Tyr Pro Thr 
305                 310                 315                 320 

Thr Gln Thr His Ala Asp Ile Pro Ala Glu Val Arg His Ser Tyr Gly 
                325                 330                 335     

Leu Thr Asp Asp Leu Leu Arg Leu Ser Ile Gly Ile Glu Asp Ala Arg 
            340                 345                 350         

Asp Leu Ile Ala Asp Leu Arg Gln Ala Ile Glu Gly 
        355                 360                 

<210>   3121
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3121
gtgattatag cgcatcgttt gtcaacggta aaagatgtgg attgtatttt cttcttagag   60
gaggggaaaa tcactggctc aggaactcat aaggaactac tggaaaatca tgagcgttat   120
gctcgttttg tgcaggagca aatgatagag                                    150

<210>   3122
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   penicillin binding protein, putative

<400>   3122
Met Ile Ile Ala His Arg Leu Ser Thr Val Lys Asp Val Asp Cys Ile 
1               5                   10                  15      

Phe Phe Leu Glu Glu Gly Lys Ile Thr Gly Ser Gly Thr His Lys Glu 
            20                  25                  30          

Leu Leu Glu Asn His Glu Arg Tyr Ala Arg Phe Val Gln Glu Gln Met 
        35                  40                  45              

Ile Glu 
    50  

<210>   3123
<211>   1397
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3123
atgaaattaa aattattaag agtagatact aaggtgatta tggggagttt cttacttgtt   60
ctgtctagtc tacttgcttt gttgcttccc cttatcttaa aggatttaat agatgggagt   120
tctattgaaa atataggctc caaagtattt caatcgtttt tgatttttat tggtcaagcc   180
ttgttttctt ctattggtta ctatctgttt agtcaatcgg gtgaaaaaaa gatagcaaaa   240
atcaggaaaa aagtgataga ggggttgatt tatgtagaga aatccttctt tgataagagc   300
caaagtgggg agttgacttc tgccattgtc aatgacacga gtgtcattcg tgagttttta   360
attacgactt tcccaaatat tattctgagt ttagttatgg tacttggttc cattgtagtc   420
ttatttagtc ttgattggaa tctttctcta cttttattca tcactcttcc ttgtatgatg   480
tttattatct tgcccctttc caatatcagt gaaaagtata gtcgtcgttt acaggaggaa   540
atttaacagg gcaattgact gaaaagattc aagaacatga attaattaag actaaccaag   600
cagagaaaag tgtacaggat gttttggata attgtattga aagggtacaa aacaattcac   660
tgaaatcaga tagggttact tcttttgaga ccccgtttgc tctcttattt atctttgcga   720
ctatagctgt gatgctaacc tatgggggtt atcgggtcag cgcaggatat atatctgtgg   780
gaaccttggt ttcgtttttg atttacctct ttcaattact taatcctatt agtaatatag   840
ctaattttgt aactgtttat tctaggagca agggatcttc agttgcactg gagaacttgc   900
ttgcagttcc taaagaaaaa tttgagggag gaaaatcggt atcaggacga gggttgaatt   960
ttaaccatgt ctattttggt tatgatgaaa atcgacctgt cttaaaggat attacttgtt   1020
caattttcaa ggggcaaaaa attgcttttg ttggaccatc tggatcagga aaatcaacga   1080
ttgtgcgttt gttagagcgg ttttataaac cgctttcagg agatattcta atggagcaat   1140
caagtatata tgattttaac ttaaaagaat ggagaagtaa aatcgcttgg gtttcacaaa   1200
ataatgcagt cttatctggc agtattcgtg acaatctttg tctcggtttg aatcgcttag   1260
taactgatga tgaattgatg aaagtgctag acttagtatc actaggtgat gagattcgct   1320
ccatgaaaga gggactagat actgaagttg gtgaacgcgg acgactcttg tcaggggggc   1380
gaacgaaaga cttcaaa                                                  1397

<210>   3124
<211>   281
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein FRAMESHIFT

<400>   3124
Met Thr Glu Lys Ile Gln Glu His Glu Leu Ile Lys Thr Asn Gln Ala 
1               5                   10                  15      

Glu Lys Ser Val Gln Asp Val Leu Asp Asn Cys Ile Glu Arg Val Gln 
            20                  25                  30          

Asn Asn Ser Leu Lys Ser Asp Arg Val Thr Ser Phe Glu Thr Pro Phe 
        35                  40                  45              

Ala Leu Leu Phe Ile Phe Ala Thr Ile Ala Val Met Leu Thr Tyr Gly 
    50                  55                  60                  

Gly Tyr Arg Val Ser Ala Gly Tyr Ile Ser Val Gly Thr Leu Val Ser 
65                  70                  75                  80  

Phe Leu Ile Tyr Leu Phe Gln Leu Leu Asn Pro Ile Ser Asn Ile Ala 
                85                  90                  95      

Asn Phe Val Thr Val Tyr Ser Arg Ser Lys Gly Ser Ser Val Ala Leu 
            100                 105                 110         

Glu Asn Leu Leu Ala Val Pro Lys Glu Lys Phe Glu Gly Gly Lys Ser 
        115                 120                 125             

Val Ser Gly Arg Gly Leu Asn Phe Asn His Val Tyr Phe Gly Tyr Asp 
    130                 135                 140                 

Glu Asn Arg Pro Val Leu Lys Asp Ile Thr Cys Ser Ile Phe Lys Gly 
145                 150                 155                 160 

Gln Lys Ile Ala Phe Val Gly Pro Ser Gly Ser Gly Lys Ser Thr Ile 
                165                 170                 175     

Val Arg Leu Leu Glu Arg Phe Tyr Lys Pro Leu Ser Gly Asp Ile Leu 
            180                 185                 190         

Met Glu Gln Ser Ser Ile Tyr Asp Phe Asn Leu Lys Glu Trp Arg Ser 
        195                 200                 205             

Lys Ile Ala Trp Val Ser Gln Asn Asn Ala Val Leu Ser Gly Ser Ile 
    210                 215                 220                 

Arg Asp Asn Leu Cys Leu Gly Leu Asn Arg Leu Val Thr Asp Asp Glu 
225                 230                 235                 240 

Leu Met Lys Val Leu Asp Leu Val Ser Leu Gly Asp Glu Ile Arg Ser 
                245                 250                 255     

Met Lys Glu Gly Leu Asp Thr Glu Val Gly Glu Arg Gly Arg Leu Leu 
            260                 265                 270         

Ser Gly Gly Arg Thr Lys Asp Phe Lys 
        275                 280     

<210>   3125
<211>   543
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3125
atgaaattaa aattattaag agtagatact aaggtgatta tggggagttt cttacttgtt   60
ctgtctagtc tacttgcttt gttgcttccc cttatcttaa aggatttaat agatgggagt   120
tctattgaaa atataggctc caaagtattt caatcgtttt tgatttttat tggtcaagcc   180
ttgttttctt ctattggtta ctatctgttt agtcaatcgg gtgaaaaaaa gatagcaaaa   240
atcaggaaaa aagtgataga ggggttgatt tatgtagaga aatccttctt tgataagagc   300
caaagtgggg agttgacttc tgccattgtc aatgacacga gtgtcattcg tgagttttta   360
attacgactt tcccaaatat tattctgagt ttagttatgg tacttggttc cattgtagtc   420
ttatttagtc ttgattggaa tctttctcta cttttattca tcactcttcc ttgtatgatg   480
tttattatct tgcccctttc caatatcagt gaaaagtata gtcgtcgttt acaggaggaa   540
att                                                                 543

<210>   3126
<211>   181
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   multidrug resistance protein, putative FRAMESHIFT

<400>   3126
Met Lys Leu Lys Leu Leu Arg Val Asp Thr Lys Val Ile Met Gly Ser 
1               5                   10                  15      

Phe Leu Leu Val Leu Ser Ser Leu Leu Ala Leu Leu Leu Pro Leu Ile 
            20                  25                  30          

Leu Lys Asp Leu Ile Asp Gly Ser Ser Ile Glu Asn Ile Gly Ser Lys 
        35                  40                  45              

Val Phe Gln Ser Phe Leu Ile Phe Ile Gly Gln Ala Leu Phe Ser Ser 
    50                  55                  60                  

Ile Gly Tyr Tyr Leu Phe Ser Gln Ser Gly Glu Lys Lys Ile Ala Lys 
65                  70                  75                  80  

Ile Arg Lys Lys Val Ile Glu Gly Leu Ile Tyr Val Glu Lys Ser Phe 
                85                  90                  95      

Phe Asp Lys Ser Gln Ser Gly Glu Leu Thr Ser Ala Ile Val Asn Asp 
            100                 105                 110         

Thr Ser Val Ile Arg Glu Phe Leu Ile Thr Thr Phe Pro Asn Ile Ile 
        115                 120                 125             

Leu Ser Leu Val Met Val Leu Gly Ser Ile Val Val Leu Phe Ser Leu 
    130                 135                 140                 

Asp Trp Asn Leu Ser Leu Leu Leu Phe Ile Thr Leu Pro Cys Met Met 
145                 150                 155                 160 

Phe Ile Ile Leu Pro Leu Ser Asn Ile Ser Glu Lys Tyr Ser Arg Arg 
                165                 170                 175     

Leu Gln Glu Glu Ile 
            180     

<210>   3127
<211>   1956
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3127
atgaaaaagt ctaagagcaa atatctaacc ttggcaggtc ttgtcctggg tacaggagtt   60
ttattgagcg cgtgtggaaa ttctagcacg gcgtcaaaaa cctacaacta tgtttattca   120
agtgatccat ctagcttgaa ctatctagca gaaaaccgcg cagcaacatc cgatattgtt   180
gcaaatttgg tagacgggtt attagaaaat gaccaatatg ggaatattat tccatcatta   240
gcagaggatt ggactgtttc tcaggacggt ttgacctata cctacaaact tcgtaaggat   300
gccaagtggt ttacttctga gggagaagaa tatgcgcctg taactgccca ggattttgtg   360
acaggtttgc aatatgcagc tgataaaaaa tcagaagcct tgtatctagt gcaggactct   420
gttgctggtt tggatgacta tatcactggt aaaacaagcg acttttcaac tgtcggtgtc   480
aaggcacttg atgaccaaac ggttcaatat actttggtta aaccagaact ttactggaat   540
tcaaaaacac ttgcaacgat actttttcct gttaatgcag atttcctgaa atcaaaaggg   600
gatgattttg ggaaggcgga tccatctagt attttgtaca atggaccttt cttgatgaaa   660
gcacttgtct caaaatctgc tattgaatat aagaaaaacc ctaattactg ggatgctaag   720
aatgtctttg tagacgatgt gaaattgacc tactatgatg gtagcgacca agaatcactg   780
gaacgtaatt ttacagctgg tgcttatact acggctcgtc tttttcctaa cagctccagc   840
tatgaaggga ttaaagaaaa atacaaaaac aatatcatct atagtatgca aaattcaact   900
tcatatttct ttaattttaa cctagatagg aagtcttaca attatacttc taaaacaagt   960
gacattgaaa agaaatcgac tcaggaagca gttctcaata aaaacttccg tcaggctatc   1020
aattttgctt ttgacagaac atcttatggg gctcagtctg aagggaaaga aggtgcaaca   1080
aagattttgc gtaacctagt ggttcctcca aactttgtca gtatcaaggg aaaagacttt   1140
ggtgaagttg tagcctctaa gatggtcaac tatggtaagg aatggcaagg tatcaacttt   1200
gcggatggtc aagaccctta ctacaatcct gagaaagcca aggctaagtt tgcggaagct   1260
aagaaagaac tcgaagcaaa gggtgttcaa ttcccaatcc acttggataa gactgtggaa   1320
gtaacagata aagtaggcat acaaggagtt agttctatca aacaatcaat tgaatctgtt   1380
ttaggttctg ataatgtagt gattgacatt cagcaattaa catcagatga gtttgacagt   1440
tcaggctact ttgctcaaac agctgctcag aaagattatg atttatatca tggcggttgg   1500
ggacctgatt atcaagaccc gtcaacctat ctcgatattt ttaatactaa tagtggagga   1560
tttctgcaaa atcttggact agagcctggt gaggccaatg acaaggctaa ggcagttgga   1620
ctggatgtct atactcaaat gttggaagaa gctaataaag agcaagatcc ggccaaacgt   1680
tatgagaaat atgctgatat tcaagcttgg ttgattgata gttctttagt tcttccaagt   1740
gtttcgcgtg ggggaacacc atcattgaga agaaccgtac catttgctgc tgcctatggt   1800
ttaaccggta caaaaggggt tgaatcatat aaatacctca aagtacaaga taagattgtc   1860
acaacagacg aatatgcaaa agccagagaa aaatggttga aagaaaaaga agaatccaat   1920
aaaaaagccc aagaagaatt ggcaaaacat gtcaaa                             1956

<210>   3128
<211>   652
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligopeptide ABC transporter, oligopeptide-binding protein AliB (aliB)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903425 (0.E+01)

<400>   3128
Met Lys Lys Ser Lys Ser Lys Tyr Leu Thr Leu Ala Gly Leu Val Leu 
1               5                   10                  15      

Gly Thr Gly Val Leu Leu Ser Ala Cys Gly Asn Ser Ser Thr Ala Ser 
            20                  25                  30          

Lys Thr Tyr Asn Tyr Val Tyr Ser Ser Asp Pro Ser Ser Leu Asn Tyr 
        35                  40                  45              

Leu Ala Glu Asn Arg Ala Ala Thr Ser Asp Ile Val Ala Asn Leu Val 
    50                  55                  60                  

Asp Gly Leu Leu Glu Asn Asp Gln Tyr Gly Asn Ile Ile Pro Ser Leu 
65                  70                  75                  80  

Ala Glu Asp Trp Thr Val Ser Gln Asp Gly Leu Thr Tyr Thr Tyr Lys 
                85                  90                  95      

Leu Arg Lys Asp Ala Lys Trp Phe Thr Ser Glu Gly Glu Glu Tyr Ala 
            100                 105                 110         

Pro Val Thr Ala Gln Asp Phe Val Thr Gly Leu Gln Tyr Ala Ala Asp 
        115                 120                 125             

Lys Lys Ser Glu Ala Leu Tyr Leu Val Gln Asp Ser Val Ala Gly Leu 
    130                 135                 140                 

Asp Asp Tyr Ile Thr Gly Lys Thr Ser Asp Phe Ser Thr Val Gly Val 
145                 150                 155                 160 

Lys Ala Leu Asp Asp Gln Thr Val Gln Tyr Thr Leu Val Lys Pro Glu 
                165                 170                 175     

Leu Tyr Trp Asn Ser Lys Thr Leu Ala Thr Ile Leu Phe Pro Val Asn 
            180                 185                 190         

Ala Asp Phe Leu Lys Ser Lys Gly Asp Asp Phe Gly Lys Ala Asp Pro 
        195                 200                 205             

Ser Ser Ile Leu Tyr Asn Gly Pro Phe Leu Met Lys Ala Leu Val Ser 
    210                 215                 220                 

Lys Ser Ala Ile Glu Tyr Lys Lys Asn Pro Asn Tyr Trp Asp Ala Lys 
225                 230                 235                 240 

Asn Val Phe Val Asp Asp Val Lys Leu Thr Tyr Tyr Asp Gly Ser Asp 
                245                 250                 255     

Gln Glu Ser Leu Glu Arg Asn Phe Thr Ala Gly Ala Tyr Thr Thr Ala 
            260                 265                 270         

Arg Leu Phe Pro Asn Ser Ser Ser Tyr Glu Gly Ile Lys Glu Lys Tyr 
        275                 280                 285             

Lys Asn Asn Ile Ile Tyr Ser Met Gln Asn Ser Thr Ser Tyr Phe Phe 
    290                 295                 300                 

Asn Phe Asn Leu Asp Arg Lys Ser Tyr Asn Tyr Thr Ser Lys Thr Ser 
305                 310                 315                 320 

Asp Ile Glu Lys Lys Ser Thr Gln Glu Ala Val Leu Asn Lys Asn Phe 
                325                 330                 335     

Arg Gln Ala Ile Asn Phe Ala Phe Asp Arg Thr Ser Tyr Gly Ala Gln 
            340                 345                 350         

Ser Glu Gly Lys Glu Gly Ala Thr Lys Ile Leu Arg Asn Leu Val Val 
        355                 360                 365             

Pro Pro Asn Phe Val Ser Ile Lys Gly Lys Asp Phe Gly Glu Val Val 
    370                 375                 380                 

Ala Ser Lys Met Val Asn Tyr Gly Lys Glu Trp Gln Gly Ile Asn Phe 
385                 390                 395                 400 

Ala Asp Gly Gln Asp Pro Tyr Tyr Asn Pro Glu Lys Ala Lys Ala Lys 
                405                 410                 415     

Phe Ala Glu Ala Lys Lys Glu Leu Glu Ala Lys Gly Val Gln Phe Pro 
            420                 425                 430         

Ile His Leu Asp Lys Thr Val Glu Val Thr Asp Lys Val Gly Ile Gln 
        435                 440                 445             

Gly Val Ser Ser Ile Lys Gln Ser Ile Glu Ser Val Leu Gly Ser Asp 
    450                 455                 460                 

Asn Val Val Ile Asp Ile Gln Gln Leu Thr Ser Asp Glu Phe Asp Ser 
465                 470                 475                 480 

Ser Gly Tyr Phe Ala Gln Thr Ala Ala Gln Lys Asp Tyr Asp Leu Tyr 
                485                 490                 495     

His Gly Gly Trp Gly Pro Asp Tyr Gln Asp Pro Ser Thr Tyr Leu Asp 
            500                 505                 510         

Ile Phe Asn Thr Asn Ser Gly Gly Phe Leu Gln Asn Leu Gly Leu Glu 
        515                 520                 525             

Pro Gly Glu Ala Asn Asp Lys Ala Lys Ala Val Gly Leu Asp Val Tyr 
    530                 535                 540                 

Thr Gln Met Leu Glu Glu Ala Asn Lys Glu Gln Asp Pro Ala Lys Arg 
545                 550                 555                 560 

Tyr Glu Lys Tyr Ala Asp Ile Gln Ala Trp Leu Ile Asp Ser Ser Leu 
                565                 570                 575     

Val Leu Pro Ser Val Ser Arg Gly Gly Thr Pro Ser Leu Arg Arg Thr 
            580                 585                 590         

Val Pro Phe Ala Ala Ala Tyr Gly Leu Thr Gly Thr Lys Gly Val Glu 
        595                 600                 605             

Ser Tyr Lys Tyr Leu Lys Val Gln Asp Lys Ile Val Thr Thr Asp Glu 
    610                 615                 620                 

Tyr Ala Lys Ala Arg Glu Lys Trp Leu Lys Glu Lys Glu Glu Ser Asn 
625                 630                 635                 640 


Lys Lys Ala Gln Glu Glu Leu Ala Lys His Val Lys 
                645                 650         

<210>   3129
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3129
ttgatttttt ggaaaaaaca attgactaaa caaaccaaga gttgtataat aaaacaaata   60
tttaaagcag gaggttccgg aaatgaaaaa gtc                                93

<210>   3130
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3130
Met Ile Phe Trp Lys Lys Gln Leu Thr Lys Gln Thr Lys Ser Cys Ile 
1               5                   10                  15      

Ile Lys Gln Ile Phe Lys Ala Gly Gly Ser Gly Asn Glu Lys Val 
            20                  25                  30      

<210>   3131
<211>   1635
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   3131
ttgaatgagg aatctatgtc gcacgaaaac aatcaccagc aggcccagat gttacggggg   60
actgcttggc taacggctag taactttatc agtcgcctac tcggggctgt ttacattatc   120
ccttggtaca tctggatggg ggcttatgca gctaaggcaa atggtctctt taccatgggt   180
tacaatatct atgcttggtt cttgttggtt tcaacagcgg ggattccagt tgcggtggcc   240
aagcaagttg ccaagtataa taccatgcga gaagaagagc atagctttgc cctgattcgg   300
agcttcttag gctttatgac aggactaggc ctggtttttg ctttagtctt gtatgtcttt   360
gctccttggc tagcagactt gtctggcgtg ggcaaagact tgatcccaat catgcaaagc   420
ttggcttggg gagtcttgat tttcccgtct atgagtgtta tccgaggatt tttccaaggg   480
atgaataacc tcaaacccta tgccatgagc caaattgctg agcaggtcat tcgtgttatc   540
tggatgctcc tagcaacctt tatcattatg aagctcggtt caggagatta tctagcagcc   600
gttacccaat caacctttgc tgcctttgtc ggtatggtag ccagttttgc agtcttgatt   660
tatttccttg cccaagaagg ttcactcaaa agaatctttg aaacaggaga taagattaac   720
agtaagcgtc tcttggttga taccattaag gaagccattc cttttatcct gacagggtct   780
gccatccagc tcttccagat tttggatcag ctgaccttta tcaatagtat gagctggttt   840
accaactaca gcaatgagga cttggttgtc atgttttctt atttctcagc caatcctaat   900
aaaatcacga tgattttgat ttctgtaggg gtttcgattg ggagtgttgg tttgccactt   960
ttgacggaaa actatgtcaa gggggacttg aaagcagctt ctcgtctcgt tcaggacagt   1020
ctcaccctac tctttatgtt cttgctacca gcaacggttg gagtggttat ggtaggagaa   1080
cctctttata cggtcttcta tggtaagcca gatagtttgg ctctgggctt atttgtcttt   1140
gcagttttgc agtctattat tttaggcttg tacatggtct tgtctccaat gcttcaggcc   1200
atgttccgca accgcaaggc cgttctctat tttatctatg gttctattgc caagctagtc   1260
ttgcaactac ctaccatcgc cctcttccac agttatggtc ctttgatttc aacaaccatt   1320
gctctcatca ttcctaacgt cttgatgtat cgggatattt gtaaagtaac tggtgtcaag   1380
cgcaaggtga ttttgaagcg aaccatttta atcagtttgc tgaccctagt catgtttctg   1440
ttaataggaa ccatccagtg gctgttagga tttttcttcc aaccaagtgg acgtttgtgg   1500
agcttctttt atgtagctct tgtcggtgcc atggggggtg gactttatat ggttatgagt   1560
ctgcgtacct atttattaga taaggtaata ggaaaagccc aagcagatcg cctgcgagca   1620
aaatttaagc tttcg                                                    1635

<210>   3132
<211>   545
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   polysaccharide biosynthesis protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903426 (0.E+01)

<400>   3132
Met Asn Glu Glu Ser Met Ser His Glu Asn Asn His Gln Gln Ala Gln 
1               5                   10                  15      

Met Leu Arg Gly Thr Ala Trp Leu Thr Ala Ser Asn Phe Ile Ser Arg 
            20                  25                  30          

Leu Leu Gly Ala Val Tyr Ile Ile Pro Trp Tyr Ile Trp Met Gly Ala 
        35                  40                  45              

Tyr Ala Ala Lys Ala Asn Gly Leu Phe Thr Met Gly Tyr Asn Ile Tyr 
    50                  55                  60                  

Ala Trp Phe Leu Leu Val Ser Thr Ala Gly Ile Pro Val Ala Val Ala 
65                  70                  75                  80  

Lys Gln Val Ala Lys Tyr Asn Thr Met Arg Glu Glu Glu His Ser Phe 
                85                  90                  95      

Ala Leu Ile Arg Ser Phe Leu Gly Phe Met Thr Gly Leu Gly Leu Val 
            100                 105                 110         

Phe Ala Leu Val Leu Tyr Val Phe Ala Pro Trp Leu Ala Asp Leu Ser 
        115                 120                 125             

Gly Val Gly Lys Asp Leu Ile Pro Ile Met Gln Ser Leu Ala Trp Gly 
    130                 135                 140                 

Val Leu Ile Phe Pro Ser Met Ser Val Ile Arg Gly Phe Phe Gln Gly 
145                 150                 155                 160 

Met Asn Asn Leu Lys Pro Tyr Ala Met Ser Gln Ile Ala Glu Gln Val 
                165                 170                 175     

Ile Arg Val Ile Trp Met Leu Leu Ala Thr Phe Ile Ile Met Lys Leu 
            180                 185                 190         

Gly Ser Gly Asp Tyr Leu Ala Ala Val Thr Gln Ser Thr Phe Ala Ala 
        195                 200                 205             

Phe Val Gly Met Val Ala Ser Phe Ala Val Leu Ile Tyr Phe Leu Ala 
    210                 215                 220                 

Gln Glu Gly Ser Leu Lys Arg Ile Phe Glu Thr Gly Asp Lys Ile Asn 
225                 230                 235                 240 

Ser Lys Arg Leu Leu Val Asp Thr Ile Lys Glu Ala Ile Pro Phe Ile 
                245                 250                 255     

Leu Thr Gly Ser Ala Ile Gln Leu Phe Gln Ile Leu Asp Gln Leu Thr 
            260                 265                 270         

Phe Ile Asn Ser Met Ser Trp Phe Thr Asn Tyr Ser Asn Glu Asp Leu 
        275                 280                 285             

Val Val Met Phe Ser Tyr Phe Ser Ala Asn Pro Asn Lys Ile Thr Met 
    290                 295                 300                 

Ile Leu Ile Ser Val Gly Val Ser Ile Gly Ser Val Gly Leu Pro Leu 
305                 310                 315                 320 

Leu Thr Glu Asn Tyr Val Lys Gly Asp Leu Lys Ala Ala Ser Arg Leu 
                325                 330                 335     

Val Gln Asp Ser Leu Thr Leu Leu Phe Met Phe Leu Leu Pro Ala Thr 
            340                 345                 350         

Val Gly Val Val Met Val Gly Glu Pro Leu Tyr Thr Val Phe Tyr Gly 
        355                 360                 365             

Lys Pro Asp Ser Leu Ala Leu Gly Leu Phe Val Phe Ala Val Leu Gln 
    370                 375                 380                 

Ser Ile Ile Leu Gly Leu Tyr Met Val Leu Ser Pro Met Leu Gln Ala 
385                 390                 395                 400 

Met Phe Arg Asn Arg Lys Ala Val Leu Tyr Phe Ile Tyr Gly Ser Ile 
                405                 410                 415     

Ala Lys Leu Val Leu Gln Leu Pro Thr Ile Ala Leu Phe His Ser Tyr 
            420                 425                 430         

Gly Pro Leu Ile Ser Thr Thr Ile Ala Leu Ile Ile Pro Asn Val Leu 
        435                 440                 445             

Met Tyr Arg Asp Ile Cys Lys Val Thr Gly Val Lys Arg Lys Val Ile 
    450                 455                 460                 

Leu Lys Arg Thr Ile Leu Ile Ser Leu Leu Thr Leu Val Met Phe Leu 
465                 470                 475                 480 

Leu Ile Gly Thr Ile Gln Trp Leu Leu Gly Phe Phe Phe Gln Pro Ser 
                485                 490                 495     

Gly Arg Leu Trp Ser Phe Phe Tyr Val Ala Leu Val Gly Ala Met Gly 
            500                 505                 510         

Gly Gly Leu Tyr Met Val Met Ser Leu Arg Thr Tyr Leu Leu Asp Lys 
        515                 520                 525             

Val Ile Gly Lys Ala Gln Ala Asp Arg Leu Arg Ala Lys Phe Lys Leu 
    530                 535                 540                 

Ser 
545 

<210>   3133
<211>   1443
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3133
atgattaaga ttgaaaccgt attagatatt ttaaagaaag atggcctttt tcgcgaaatt   60
attgaccaag gtcattacca ctacaactac agcaaagtta tttttgatag catcagctac   120
gacagccgaa aagtaacaga agacactctt tttttcgcaa aaggcgctgc ctttaaaaaa   180
gaataccttc tttctgctat aacacaagga ttagcttggt atgtagctga aaaggactac   240
gaagtcggta tccctgtcat cattgtgaac gatataaaga aagccatgag tttgattgcc   300
atggagttct atggtaatcc acaggaaaaa ctcaaactcc ttgcctttac tggtactaag   360
ggtaagacaa cagcagccta tttcgcctat aacatcttat ctcaagggca tagacctgct   420
atgttgtcga ccatgaacac aactcttgat ggcgagactt tctttaagtc agcgttgaca   480
acccctgaga gtattgacct ctttgacatg atgaatcagg ctgtgcaaaa tgaccgtacc   540
cacctcatca tggaagtctc cagtcaagcc tatctggtca aacgtgtcta tggtctaacc   600
tttgatgtgg gagttttcct aaatatcagc ccagaccata tcggcccgat tgaacaccct   660
agctttgaag actatttcta ccacaagcgt ctcttgatgg aaaagagccg agcagtcatc   720
attaacagtg acatggacca cttctcagtc ttgaaagaac aggttgaaga tcaagaccat   780
gatttctatg gtagccaatt tgataaccaa atcgagaatt ccaaagcctt tagcttttca   840
gctacgggta aactcgctgg agattatgat attcaactca ttggcaactt caaccaagaa   900
aatgcagttg ctgctggact tgcttgtctc cgtctcggag caagtcttga ggacatcaaa   960
aaaggcatcg ctgcaacccg cgttcctggt cgtatggaag tcctcactca gaaaaatgga   1020
gccaaggtct tcatcgacta tgcccacaat ggggatagtc tgaaaaaact catcaatgtg   1080
gttgaaactc atcaaaccgg aaagattgct ctggttctgg gatcaacagg aaacaaggga   1140
gaaagtcgtc gtaaggactt tggcctcctc ctcaatcaac accctgagat tcaagtcttt   1200
ctgactgctg atgaccctaa ctatgaagac ccaatggcca ttgcagatga aattagtagc   1260
tacatcaatc atcctgttga aaagattgcg gatcgccaag aagccatcaa ggcggcaatg   1320
gctatcacaa atcacgaatt agatgcagtt attattgcgg gtaagggagc cgattgttac   1380
caaatcatcc agggcaagaa agaatcctac ccaggagata cagccgtcgc agaaaattat   1440
tta                                                                 1443

<210>   3134
<211>   481
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (mur
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903427 (0.E+01)

<400>   3134
Met Ile Lys Ile Glu Thr Val Leu Asp Ile Leu Lys Lys Asp Gly Leu 
1               5                   10                  15      

Phe Arg Glu Ile Ile Asp Gln Gly His Tyr His Tyr Asn Tyr Ser Lys 
            20                  25                  30          

Val Ile Phe Asp Ser Ile Ser Tyr Asp Ser Arg Lys Val Thr Glu Asp 
        35                  40                  45              

Thr Leu Phe Phe Ala Lys Gly Ala Ala Phe Lys Lys Glu Tyr Leu Leu 
    50                  55                  60                  

Ser Ala Ile Thr Gln Gly Leu Ala Trp Tyr Val Ala Glu Lys Asp Tyr 
65                  70                  75                  80  

Glu Val Gly Ile Pro Val Ile Ile Val Asn Asp Ile Lys Lys Ala Met 
                85                  90                  95      

Ser Leu Ile Ala Met Glu Phe Tyr Gly Asn Pro Gln Glu Lys Leu Lys 
            100                 105                 110         

Leu Leu Ala Phe Thr Gly Thr Lys Gly Lys Thr Thr Ala Ala Tyr Phe 
        115                 120                 125             

Ala Tyr Asn Ile Leu Ser Gln Gly His Arg Pro Ala Met Leu Ser Thr 
    130                 135                 140                 

Met Asn Thr Thr Leu Asp Gly Glu Thr Phe Phe Lys Ser Ala Leu Thr 
145                 150                 155                 160 

Thr Pro Glu Ser Ile Asp Leu Phe Asp Met Met Asn Gln Ala Val Gln 
                165                 170                 175     

Asn Asp Arg Thr His Leu Ile Met Glu Val Ser Ser Gln Ala Tyr Leu 
            180                 185                 190         

Val Lys Arg Val Tyr Gly Leu Thr Phe Asp Val Gly Val Phe Leu Asn 
        195                 200                 205             

Ile Ser Pro Asp His Ile Gly Pro Ile Glu His Pro Ser Phe Glu Asp 
    210                 215                 220                 

Tyr Phe Tyr His Lys Arg Leu Leu Met Glu Lys Ser Arg Ala Val Ile 
225                 230                 235                 240 

Ile Asn Ser Asp Met Asp His Phe Ser Val Leu Lys Glu Gln Val Glu 
                245                 250                 255     

Asp Gln Asp His Asp Phe Tyr Gly Ser Gln Phe Asp Asn Gln Ile Glu 
            260                 265                 270         

Asn Ser Lys Ala Phe Ser Phe Ser Ala Thr Gly Lys Leu Ala Gly Asp 
        275                 280                 285             

Tyr Asp Ile Gln Leu Ile Gly Asn Phe Asn Gln Glu Asn Ala Val Ala 
    290                 295                 300                 

Ala Gly Leu Ala Cys Leu Arg Leu Gly Ala Ser Leu Glu Asp Ile Lys 
305                 310                 315                 320 

Lys Gly Ile Ala Ala Thr Arg Val Pro Gly Arg Met Glu Val Leu Thr 
                325                 330                 335     

Gln Lys Asn Gly Ala Lys Val Phe Ile Asp Tyr Ala His Asn Gly Asp 
            340                 345                 350         

Ser Leu Lys Lys Leu Ile Asn Val Val Glu Thr His Gln Thr Gly Lys 
        355                 360                 365             

Ile Ala Leu Val Leu Gly Ser Thr Gly Asn Lys Gly Glu Ser Arg Arg 
    370                 375                 380                 

Lys Asp Phe Gly Leu Leu Leu Asn Gln His Pro Glu Ile Gln Val Phe 
385                 390                 395                 400 

Leu Thr Ala Asp Asp Pro Asn Tyr Glu Asp Pro Met Ala Ile Ala Asp 
                405                 410                 415     

Glu Ile Ser Ser Tyr Ile Asn His Pro Val Glu Lys Ile Ala Asp Arg 
            420                 425                 430         

Gln Glu Ala Ile Lys Ala Ala Met Ala Ile Thr Asn His Glu Leu Asp 
        435                 440                 445             

Ala Val Ile Ile Ala Gly Lys Gly Ala Asp Cys Tyr Gln Ile Ile Gln 
    450                 455                 460                 

Gly Lys Lys Glu Ser Tyr Pro Gly Asp Thr Ala Val Ala Glu Asn Tyr 
465                 470                 475                 480 

Leu 
    

<210>   3135
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3135
atgtcacttg aaaacaaatt ggaacaagca acaggcgctg tcaaagaagg ttttggtaaa   60
gttactggag acagcaagac agaacttgaa ggagctgttg aaaaaacagt tgctaaggca   120
aaagacgttg tagaagacgc aaaaggtgct gtagaaggtg ccgttgaagg tttgaaaaac   180
gtttttacta aagaa                                                    195

<210>   3136
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903428 (3.E-31)

<400>   3136
Met Ser Leu Glu Asn Lys Leu Glu Gln Ala Thr Gly Ala Val Lys Glu 
1               5                   10                  15      

Gly Phe Gly Lys Val Thr Gly Asp Ser Lys Thr Glu Leu Glu Gly Ala 
            20                  25                  30          

Val Glu Lys Thr Val Ala Lys Ala Lys Asp Val Val Glu Asp Ala Lys 
        35                  40                  45              

Gly Ala Val Glu Gly Ala Val Glu Gly Leu Lys Asn Val Phe Thr Lys 
    50                  55                  60                  

Glu 
65  

<210>   3137
<211>   501
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3137
ttgatccgct atctggatca gtatgaggat gtgattctac gggaaattaa ggctcaattt   60
ccagatgttg cagttgataa actcatggaa gagtatataa aggcaggctt gattctacgt   120
gaaaataagc gctattacct caattttcct acgcttgaat cacttgatag tcttgaactg   180
gatcaagaga tttttgtcag agaagctagt ccggtctatc aagccttgtt ggagcagagt   240
tttgagacgg aattgcgcaa tcaaatcaat gcagctattt tagttgaaaa gacggacttt   300
gcgcgcatta aaatgaccct gtccaattat ttttacaagg tcaaacagca gtatcctttg   360
acagaaaaac agcaggagct ctatgacatt ttaggagatg ttaatcctga gtatgccctc   420
aagtatatga cggctttttt gttgaaattt ctcaaaaaag accagcttat gcagaaatgc   480
cgtgatatct ttgtggacag t                                             501

<210>   3138
<211>   167
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903430 (4.E-49)

<400>   3138
Met Ile Arg Tyr Leu Asp Gln Tyr Glu Asp Val Ile Leu Arg Glu Ile 
1               5                   10                  15      

Lys Ala Gln Phe Pro Asp Val Ala Val Asp Lys Leu Met Glu Glu Tyr 
            20                  25                  30          

Ile Lys Ala Gly Leu Ile Leu Arg Glu Asn Lys Arg Tyr Tyr Leu Asn 
        35                  40                  45              

Phe Pro Thr Leu Glu Ser Leu Asp Ser Leu Glu Leu Asp Gln Glu Ile 
    50                  55                  60                  

Phe Val Arg Glu Ala Ser Pro Val Tyr Gln Ala Leu Leu Glu Gln Ser 
65                  70                  75                  80  

Phe Glu Thr Glu Leu Arg Asn Gln Ile Asn Ala Ala Ile Leu Val Glu 
                85                  90                  95      

Lys Thr Asp Phe Ala Arg Ile Lys Met Thr Leu Ser Asn Tyr Phe Tyr 
            100                 105                 110         

Lys Val Lys Gln Gln Tyr Pro Leu Thr Glu Lys Gln Gln Glu Leu Tyr 
        115                 120                 125             

Asp Ile Leu Gly Asp Val Asn Pro Glu Tyr Ala Leu Lys Tyr Met Thr 
    130                 135                 140                 

Ala Phe Leu Leu Lys Phe Leu Lys Lys Asp Gln Leu Met Gln Lys Cys 
145                 150                 155                 160 

Arg Asp Ile Phe Val Asp Ser 
                165         

<210>   3139
<211>   510
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3139
atgttagaaa atggcgattt gatttttgtg agagatgggt cagacatggg acaggccatc   60
cagacttcca caggtaacta tagccatgtt gccatttatt tggatgggat gatttatcat   120
gctagtggac aggctggtgt tgtctgtcaa gaaccggcag acttctttga gtccaatcat   180
ttatacgacc tctatgttta cccagaaatg gatatccagt cggtgaagga aagagcttgc   240
aaacatcttg gagcacccta caatgcttct ttctatccag atgcagctgg tttttactgc   300
tcccagtata tagcagaaat cctacctatt tttgaaacta ttcctatgaa atttggagat   360
ggggagcagg agattagtga tttttggagg gagtattaca tagaactagg tctgcctgtt   420
cctctgaacc aagctggtac caatcctagt cagttggcag catcgcctct gttacaatgt   480
aaagaaagga atcttcatga ttcagatttt                                    510

<210>   3140
<211>   170
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903431 (e-100)

<400>   3140
Met Leu Glu Asn Gly Asp Leu Ile Phe Val Arg Asp Gly Ser Asp Met 
1               5                   10                  15      

Gly Gln Ala Ile Gln Thr Ser Thr Gly Asn Tyr Ser His Val Ala Ile 
            20                  25                  30          

Tyr Leu Asp Gly Met Ile Tyr His Ala Ser Gly Gln Ala Gly Val Val 
        35                  40                  45              

Cys Gln Glu Pro Ala Asp Phe Phe Glu Ser Asn His Leu Tyr Asp Leu 
    50                  55                  60                  

Tyr Val Tyr Pro Glu Met Asp Ile Gln Ser Val Lys Glu Arg Ala Cys 
65                  70                  75                  80  

Lys His Leu Gly Ala Pro Tyr Asn Ala Ser Phe Tyr Pro Asp Ala Ala 
                85                  90                  95      

Gly Phe Tyr Cys Ser Gln Tyr Ile Ala Glu Ile Leu Pro Ile Phe Glu 
            100                 105                 110         

Thr Ile Pro Met Lys Phe Gly Asp Gly Glu Gln Glu Ile Ser Asp Phe 
        115                 120                 125             

Trp Arg Glu Tyr Tyr Ile Glu Leu Gly Leu Pro Val Pro Leu Asn Gln 
    130                 135                 140                 

Ala Gly Thr Asn Pro Ser Gln Leu Ala Ala Ser Pro Leu Leu Gln Cys 
145                 150                 155                 160 

Lys Glu Arg Asn Leu His Asp Ser Asp Phe 
                165                 170 

<210>   3141
<211>   933
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3141
atgtccaaga ttctagtatt tggtcaccaa aatccagact cagatgccat cggatcatct   60
gtagcttttg cctaccttgc aaaagaagct tacggtttgg atacggaagc tgttgccctt   120
ggaactccaa atgaagaaac agcctttgtc ttgaactatt ttggtgtgga agcaccacgt   180
gttatcactt ctgccaaagc agagggggca gagcaagtta tcttgactga ccacaatgaa   240
ttccaacaat ctgtatcaga tatcgctgaa gtagaagttt acggtgttgt agaccaccac   300
cgtgtggcta actttgaaac tgcaagccca ctttacatgc gtttggagcc agttggatca   360
gcgtcttcaa tcgtttaccg tatgttcaaa gaacatggtg tagctgtgcc taaagagatt   420
gcaggtttga tgctttcagg tttgatttca gatacccttc ttttgaaatc accaacaaca   480
cacccaacag ataaaatcat tgctcctgaa ttggctgaat tggctggtgt gaacttggaa   540
gaatatggtt tggcaatgtt gaaagctggt accaacttgg ctagcaaatc tgctgaagaa   600
ttgattgata tcgatgctaa gacttttgaa ctcaacggaa ataatgtccg tgttgcccaa   660
gtgaacacag ttgacatcgc tgaagttttg gaacgccaag cagaaattga agctgcaatg   720
caagctgcca acgaatcaaa cggctactct gactttgtct tgatgattac agatatcgtc   780
aactcaaact cagaaatctt ggctcttggt gccaatatgg acaaggtcga agcggctttc   840
aacttcaaac ttgaaaacaa tcatgccttc cttgctggtg ccgtttcacg taagaaacaa   900
gtggtacctc aattgactga aagctttaat gcg                                933

<210>   3142
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   inorganic pyrophosphatase, manganese-dependent (ppaC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903432 (e-172)

<400>   3142
Met Ser Lys Ile Leu Val Phe Gly His Gln Asn Pro Asp Ser Asp Ala 
1               5                   10                  15      

Ile Gly Ser Ser Val Ala Phe Ala Tyr Leu Ala Lys Glu Ala Tyr Gly 
            20                  25                  30          

Leu Asp Thr Glu Ala Val Ala Leu Gly Thr Pro Asn Glu Glu Thr Ala 
        35                  40                  45              

Phe Val Leu Asn Tyr Phe Gly Val Glu Ala Pro Arg Val Ile Thr Ser 
    50                  55                  60                  

Ala Lys Ala Glu Gly Ala Glu Gln Val Ile Leu Thr Asp His Asn Glu 
65                  70                  75                  80  

Phe Gln Gln Ser Val Ser Asp Ile Ala Glu Val Glu Val Tyr Gly Val 
                85                  90                  95      

Val Asp His His Arg Val Ala Asn Phe Glu Thr Ala Ser Pro Leu Tyr 
            100                 105                 110         

Met Arg Leu Glu Pro Val Gly Ser Ala Ser Ser Ile Val Tyr Arg Met 
        115                 120                 125             

Phe Lys Glu His Gly Val Ala Val Pro Lys Glu Ile Ala Gly Leu Met 
    130                 135                 140                 

Leu Ser Gly Leu Ile Ser Asp Thr Leu Leu Leu Lys Ser Pro Thr Thr 
145                 150                 155                 160 

His Pro Thr Asp Lys Ile Ile Ala Pro Glu Leu Ala Glu Leu Ala Gly 
                165                 170                 175     

Val Asn Leu Glu Glu Tyr Gly Leu Ala Met Leu Lys Ala Gly Thr Asn 
            180                 185                 190         

Leu Ala Ser Lys Ser Ala Glu Glu Leu Ile Asp Ile Asp Ala Lys Thr 
        195                 200                 205             

Phe Glu Leu Asn Gly Asn Asn Val Arg Val Ala Gln Val Asn Thr Val 
    210                 215                 220                 

Asp Ile Ala Glu Val Leu Glu Arg Gln Ala Glu Ile Glu Ala Ala Met 
225                 230                 235                 240 

Gln Ala Ala Asn Glu Ser Asn Gly Tyr Ser Asp Phe Val Leu Met Ile 
                245                 250                 255     

Thr Asp Ile Val Asn Ser Asn Ser Glu Ile Leu Ala Leu Gly Ala Asn 
            260                 265                 270         

Met Asp Lys Val Glu Ala Ala Phe Asn Phe Lys Leu Glu Asn Asn His 
        275                 280                 285             

Ala Phe Leu Ala Gly Ala Val Ser Arg Lys Lys Gln Val Val Pro Gln 
    290                 295                 300                 

Leu Thr Glu Ser Phe Asn Ala 
305                 310     

<210>   3143
<211>   297
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3143
atggatcata aggcttatat gtacgttctg gagtgtcgtg atggatccta ctatataggc   60
tatacgactg atatgagaag acgcctcgct atccacaata gtgggaaggg agccaaatat   120
acacgagcac gcttgccagt caaacttatc tatgctcaag gttttgccag taaggaagaa   180
gccatgtcgg ctgaagctct tctcaagcgt aagaagaggc cacagaagga agaattttta   240
tctgaaaatc aagatagaaa tttactcagt tattttgaag aatcgtgggg agtcctt      297

<210>   3144
<211>   99
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903433 (7.E-54)

<400>   3144
Met Asp His Lys Ala Tyr Met Tyr Val Leu Glu Cys Arg Asp Gly Ser 
1               5                   10                  15      

Tyr Tyr Ile Gly Tyr Thr Thr Asp Met Arg Arg Arg Leu Ala Ile His 
            20                  25                  30          

Asn Ser Gly Lys Gly Ala Lys Tyr Thr Arg Ala Arg Leu Pro Val Lys 
        35                  40                  45              

Leu Ile Tyr Ala Gln Gly Phe Ala Ser Lys Glu Glu Ala Met Ser Ala 
    50                  55                  60                  

Glu Ala Leu Leu Lys Arg Lys Lys Arg Pro Gln Lys Glu Glu Phe Leu 
65                  70                  75                  80  

Ser Glu Asn Gln Asp Arg Asn Leu Leu Ser Tyr Phe Glu Glu Ser Trp 
                85                  90                  95      

Gly Val Leu 
            

<210>   3145
<211>   747
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3145
atggaagaag aacaattatt aaaatcagga gagcgcatta accagctctt ttcgacagat   60
atcaaaatca ttcaaaatag agaggttttt agctattcgg tggatagtgt tctcttatca   120
cgatttccac gttttcctaa gaaggggttg attgtggatt tctgtgctgg gaatggagca   180
gtggggcttt ttgctagcac tcgtactcaa gcacagatat tgtctgttga gattcaggag   240
cgtttggcgg atatggctga acgctctgtc cgtttgaatg gattagagga gcaaatgcag   300
gtcatctgcg atgatttgaa aaatatgcct gctcacattc aggggagtaa ggtggatatg   360
attttgtgta atccacccta tttcaaggtg aatccttatt ctaatctgaa cgagagtgaa   420
cattatctct tggctcgaca cgaaatcacg actaatttgg aagaaatctg tcgtagtgcc   480
cagagtattc tcaagtctaa tgggcgtttg gccatggttc atcgtcctga tcgacttctg   540
gatattttgg atacgttaaa acgacataat ctagccccta agcgcctgca gtttgtttat   600
ccaaaaagag aaaaggaagc caatatgctt ttgattgagg cgatcaagga tggctcaaca   660
agtggcttta aggtcttacc tcctttgatt gtccacaatg atgatggctc ttatacgccc   720
gaaatcgaag agatttatta tggatca                                       747

<210>   3146
<211>   249
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903434 (e-140)

<400>   3146
Met Glu Glu Glu Gln Leu Leu Lys Ser Gly Glu Arg Ile Asn Gln Leu 
1               5                   10                  15      

Phe Ser Thr Asp Ile Lys Ile Ile Gln Asn Arg Glu Val Phe Ser Tyr 
            20                  25                  30          

Ser Val Asp Ser Val Leu Leu Ser Arg Phe Pro Arg Phe Pro Lys Lys 
        35                  40                  45              

Gly Leu Ile Val Asp Phe Cys Ala Gly Asn Gly Ala Val Gly Leu Phe 
    50                  55                  60                  

Ala Ser Thr Arg Thr Gln Ala Gln Ile Leu Ser Val Glu Ile Gln Glu 
65                  70                  75                  80  

Arg Leu Ala Asp Met Ala Glu Arg Ser Val Arg Leu Asn Gly Leu Glu 
                85                  90                  95      

Glu Gln Met Gln Val Ile Cys Asp Asp Leu Lys Asn Met Pro Ala His 
            100                 105                 110         

Ile Gln Gly Ser Lys Val Asp Met Ile Leu Cys Asn Pro Pro Tyr Phe 
        115                 120                 125             

Lys Val Asn Pro Tyr Ser Asn Leu Asn Glu Ser Glu His Tyr Leu Leu 
    130                 135                 140                 

Ala Arg His Glu Ile Thr Thr Asn Leu Glu Glu Ile Cys Arg Ser Ala 
145                 150                 155                 160 

Gln Ser Ile Leu Lys Ser Asn Gly Arg Leu Ala Met Val His Arg Pro 
                165                 170                 175     

Asp Arg Leu Leu Asp Ile Leu Asp Thr Leu Lys Arg His Asn Leu Ala 
            180                 185                 190         

Pro Lys Arg Leu Gln Phe Val Tyr Pro Lys Arg Glu Lys Glu Ala Asn 
        195                 200                 205             

Met Leu Leu Ile Glu Ala Ile Lys Asp Gly Ser Thr Ser Gly Phe Lys 
    210                 215                 220                 

Val Leu Pro Pro Leu Ile Val His Asn Asp Asp Gly Ser Tyr Thr Pro 
225                 230                 235                 240 

Glu Ile Glu Glu Ile Tyr Tyr Gly Ser 
                245                 

<210>   3147
<211>   384
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3147
ttgaaactat tgaaatcgag gactaagatg aaaatcggtg ataagctaaa ggggcgtatt   60
acagggattc agccctacgg tgcctttgtt gagttagaga cgggtgatac ggggctgatt   120
cacatttcag agattcggac aggatttatt gaaaatattc atgaaacctt gaaagtcgat   180
gaagaggttc aagttcaggt agtggattta gatgaattta cagggaaagc cagtctttct   240
atccgcactt tggaggaaga aaagtaccag tttcctagac ggagacgctt ttcaagcgac   300
cgctttaact acggctttgc tccctttcga cgaatgctac caatctggac tggagaagcc   360
ctgcaccatt taaaaaagaa gaag                                          384

<210>   3148
<211>   128
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   general stress protein 13, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903435 (4.E-66)

<400>   3148
Met Lys Leu Leu Lys Ser Arg Thr Lys Met Lys Ile Gly Asp Lys Leu 
1               5                   10                  15      

Lys Gly Arg Ile Thr Gly Ile Gln Pro Tyr Gly Ala Phe Val Glu Leu 
            20                  25                  30          

Glu Thr Gly Asp Thr Gly Leu Ile His Ile Ser Glu Ile Arg Thr Gly 
        35                  40                  45              

Phe Ile Glu Asn Ile His Glu Thr Leu Lys Val Asp Glu Glu Val Gln 
    50                  55                  60                  

Val Gln Val Val Asp Leu Asp Glu Phe Thr Gly Lys Ala Ser Leu Ser 
65                  70                  75                  80  

Ile Arg Thr Leu Glu Glu Glu Lys Tyr Gln Phe Pro Arg Arg Arg Arg 
                85                  90                  95      

Phe Ser Ser Asp Arg Phe Asn Tyr Gly Phe Ala Pro Phe Arg Arg Met 
            100                 105                 110         

Leu Pro Ile Trp Thr Gly Glu Ala Leu His His Leu Lys Lys Lys Lys 
        115                 120                 125             



<210>   3149
<211>   1398
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3149
atggacgcga aattaagata caaggcaaag aagatcaaga ttgtcttttt tgatattgat   60
gatacattgc ggaattcaaa gacagggttt attccaacta caattcccac tgtttttaaa   120
cagttgcgtg aaaaaggaat tttaacagga atcgcctctg gacgtggcat ttttggtgtt   180
gttccagaga ttcgtgatct caagcctgac ttttttgtaa ctttgaatgg ggcttatatc   240
gaagataaaa aaggtcaggt catttatcag catcagattg aaaagtcaga tgttgaggag   300
tatatctctt gggctaagca agaaggaatt gagtatggct tggttgggag tcatgatgcc   360
aagttgtcga ctcgcaccga tatgatgagt gaagctatca atccaattta tcccgactta   420
gatgtagatc ccgatttcca tgaaaaagaa gatatctatc agatgtggac ttttgaagat   480
aagggagatg acttgcactt gcctgacagt ctctcagaca aacttcgcat ggttcgttgg   540
catcaacatt cgtctgatat tgtgccgatt tcaggctcca aagcgacggg ggtggaaaag   600
gttgtggaac accttggctt gaaaccagag aaggtcatgg tttttggaga tggtctcaac   660
gacttggaac tctttgatta tgctggaatc agcgttgcca tgggaatttc tcatgataaa   720
atcaaagaaa aagcagatta tattacaaaa acattagaag aagatggcat ttttgctgcc   780
ttagaagtat ttggtatggt agaaaaagaa ttgcattttc cacaagtaga cattgaaaca   840
gtagaaggtc ctcttgcgac tattaagacc aatcacggag acttacgtat caagcttttc   900
cctgaacatg ctcctaaaac agtggctaac tttgtatctc tttcaaaaga tggctactat   960
gatggtgtca ttttccaccg tattatcaag gactttatga tccaaggtgg agacccaact   1020
ggaactggta tgggtggcga gtcaatctac ggcgaatctt ttgaggatga attctcagaa   1080
gagctttaca atatccgtgg tgctctttcc atggcaaatg ctggtccaaa taccaacggc   1140
agccagttct ttatcgtgca aaaccaacac ctaccttatt ctaagaaaga aattactcgt   1200
ggtggttggc cagaaccgat tgcagaaatc tatgccaatc aaggtgggac acctcaccta   1260
gaccgccgtc acacggtttt tggtcagtta gctgatgaag catcttacgc tgtcttggat   1320
gccattgctg ctgttgagac aggagctatg gacaagccag ttgaagatgt tgtaattgaa   1380
actattgaaa tcgaggac                                                 1398

<210>   3150
<211>   466
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin typ
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903436 (0.E+01)

<400>   3150
Met Asp Ala Lys Leu Arg Tyr Lys Ala Lys Lys Ile Lys Ile Val Phe 
1               5                   10                  15      

Phe Asp Ile Asp Asp Thr Leu Arg Asn Ser Lys Thr Gly Phe Ile Pro 
            20                  25                  30          

Thr Thr Ile Pro Thr Val Phe Lys Gln Leu Arg Glu Lys Gly Ile Leu 
        35                  40                  45              

Thr Gly Ile Ala Ser Gly Arg Gly Ile Phe Gly Val Val Pro Glu Ile 
    50                  55                  60                  

Arg Asp Leu Lys Pro Asp Phe Phe Val Thr Leu Asn Gly Ala Tyr Ile 
65                  70                  75                  80  

Glu Asp Lys Lys Gly Gln Val Ile Tyr Gln His Gln Ile Glu Lys Ser 
                85                  90                  95      

Asp Val Glu Glu Tyr Ile Ser Trp Ala Lys Gln Glu Gly Ile Glu Tyr 
            100                 105                 110         

Gly Leu Val Gly Ser His Asp Ala Lys Leu Ser Thr Arg Thr Asp Met 
        115                 120                 125             

Met Ser Glu Ala Ile Asn Pro Ile Tyr Pro Asp Leu Asp Val Asp Pro 
    130                 135                 140                 

Asp Phe His Glu Lys Glu Asp Ile Tyr Gln Met Trp Thr Phe Glu Asp 
145                 150                 155                 160 

Lys Gly Asp Asp Leu His Leu Pro Asp Ser Leu Ser Asp Lys Leu Arg 
                165                 170                 175     

Met Val Arg Trp His Gln His Ser Ser Asp Ile Val Pro Ile Ser Gly 
            180                 185                 190         

Ser Lys Ala Thr Gly Val Glu Lys Val Val Glu His Leu Gly Leu Lys 
        195                 200                 205             

Pro Glu Lys Val Met Val Phe Gly Asp Gly Leu Asn Asp Leu Glu Leu 

    210                 215                 220                 

Phe Asp Tyr Ala Gly Ile Ser Val Ala Met Gly Ile Ser His Asp Lys 
225                 230                 235                 240 

Ile Lys Glu Lys Ala Asp Tyr Ile Thr Lys Thr Leu Glu Glu Asp Gly 
                245                 250                 255     

Ile Phe Ala Ala Leu Glu Val Phe Gly Met Val Glu Lys Glu Leu His 
            260                 265                 270         

Phe Pro Gln Val Asp Ile Glu Thr Val Glu Gly Pro Leu Ala Thr Ile 
        275                 280                 285             

Lys Thr Asn His Gly Asp Leu Arg Ile Lys Leu Phe Pro Glu His Ala 
    290                 295                 300                 

Pro Lys Thr Val Ala Asn Phe Val Ser Leu Ser Lys Asp Gly Tyr Tyr 
305                 310                 315                 320 

Asp Gly Val Ile Phe His Arg Ile Ile Lys Asp Phe Met Ile Gln Gly 
                325                 330                 335     

Gly Asp Pro Thr Gly Thr Gly Met Gly Gly Glu Ser Ile Tyr Gly Glu 
            340                 345                 350         

Ser Phe Glu Asp Glu Phe Ser Glu Glu Leu Tyr Asn Ile Arg Gly Ala 
        355                 360                 365             

Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe Phe 
    370                 375                 380                 

Ile Val Gln Asn Gln His Leu Pro Tyr Ser Lys Lys Glu Ile Thr Arg 
385                 390                 395                 400 

Gly Gly Trp Pro Glu Pro Ile Ala Glu Ile Tyr Ala Asn Gln Gly Gly 
                405                 410                 415     

Thr Pro His Leu Asp Arg Arg His Thr Val Phe Gly Gln Leu Ala Asp 
            420                 425                 430         

Glu Ala Ser Tyr Ala Val Leu Asp Ala Ile Ala Ala Val Glu Thr Gly 
        435                 440                 445             

Ala Met Asp Lys Pro Val Glu Asp Val Val Ile Glu Thr Ile Glu Ile 
    450                 455                 460                 

Glu Asp 
465     

<210>   3151
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3151
atggctcaac aacgtcgtgg cggattcaaa cgccgtaaaa aagttgatta catcgcagca   60
aacaaaattg aatatgttga ttacaaagat actgagcttc ttagccgttt cgtttcagaa   120
cgtgggaaaa tccttcctcg tcgtgtaaca ggaacttcag ctaaaaacca acgtaaagta   180
acaacagcta tcaaacgcgc tcgcgtaatg gctttgatgc ctttcgtaaa cgaagat      237

<210>   3152
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S18 (rpsR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903437 (2.E-40)

<400>   3152
Met Ala Gln Gln Arg Arg Gly Gly Phe Lys Arg Arg Lys Lys Val Asp 
1               5                   10                  15      

Tyr Ile Ala Ala Asn Lys Ile Glu Tyr Val Asp Tyr Lys Asp Thr Glu 
            20                  25                  30          

Leu Leu Ser Arg Phe Val Ser Glu Arg Gly Lys Ile Leu Pro Arg Arg 
        35                  40                  45              

Val Thr Gly Thr Ser Ala Lys Asn Gln Arg Lys Val Thr Thr Ala Ile 
    50                  55                  60                  

Lys Arg Ala Arg Val Met Ala Leu Met Pro Phe Val Asn Glu Asp 
65                  70                  75                  

<210>   3153
<211>   468
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3153
atgattaaca atgttgtact tgtagggcgt atgacacgtg acgctgagtt gcgttatacc   60
ccatcaaatg tagcagttgc gacttttact cttgcagtaa accgtacatt taagagtcaa   120
aatggtgaac gtgaggctga ttttatcaat gtcgttatgt ggcgccaaca ggctgaaaat   180
cttgctaact gggctaaaaa aggctcactt atcggggtga caggtcgtat ccagactcgt   240
agttacgata accagcaagg acaacgtgtc tacgtgacag aggtcgtggc tgagaatttc   300
caaatgttgg aaagccgtag tgtgcgtgag ggtcacacag gtggagctta ctctgcacca   360
actgcaaact attcagcacc tacaaattca gtaccagact tttcacgtaa tgaaaatcca   420
tttggagcaa caaacccatt ggatatttca gatgatgatt taccattc                468

<210>   3154
<211>   156
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   single-strand binding protein (ssb)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903438 (8.E-88)

<400>   3154
Met Ile Asn Asn Val Val Leu Val Gly Arg Met Thr Arg Asp Ala Glu 
1               5                   10                  15      

Leu Arg Tyr Thr Pro Ser Asn Val Ala Val Ala Thr Phe Thr Leu Ala 
            20                  25                  30          

Val Asn Arg Thr Phe Lys Ser Gln Asn Gly Glu Arg Glu Ala Asp Phe 
        35                  40                  45              

Ile Asn Val Val Met Trp Arg Gln Gln Ala Glu Asn Leu Ala Asn Trp 
    50                  55                  60                  

Ala Lys Lys Gly Ser Leu Ile Gly Val Thr Gly Arg Ile Gln Thr Arg 
65                  70                  75                  80  

Ser Tyr Asp Asn Gln Gln Gly Gln Arg Val Tyr Val Thr Glu Val Val 
                85                  90                  95      

Ala Glu Asn Phe Gln Met Leu Glu Ser Arg Ser Val Arg Glu Gly His 
            100                 105                 110         

Thr Gly Gly Ala Tyr Ser Ala Pro Thr Ala Asn Tyr Ser Ala Pro Thr 
        115                 120                 125             

Asn Ser Val Pro Asp Phe Ser Arg Asn Glu Asn Pro Phe Gly Ala Thr 
    130                 135                 140                 

Asn Pro Leu Asp Ile Ser Asp Asp Asp Leu Pro Phe 
145                 150                 155     

<210>   3155
<211>   288
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3155
atggctaaat acgaaattct ttatatcatt cgtccaaaca ttgaagaaga agctaaaaac   60
gctttggtag cacgttttga ctctattttg actgacaacg gtgcaactgt tgttgaatca   120
aaaacttggg aaaaacgtcg tcttgcatac gaaatccaag atttccgtga aggactttac   180
cacatcgtta acgttgaagc aaatgacgat gcagctctta aagagtttga ccgtctttca   240
aaaatcaacg ctgacattct tcgtcacatg atcgtcaaaa ttgacgcg                288

<210>   3156
<211>   96
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S6 (rpsF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903439 (1.E-50)

<400>   3156
Met Ala Lys Tyr Glu Ile Leu Tyr Ile Ile Arg Pro Asn Ile Glu Glu 
1               5                   10                  15      

Glu Ala Lys Asn Ala Leu Val Ala Arg Phe Asp Ser Ile Leu Thr Asp 
            20                  25                  30          

Asn Gly Ala Thr Val Val Glu Ser Lys Thr Trp Glu Lys Arg Arg Leu 
        35                  40                  45              

Ala Tyr Glu Ile Gln Asp Phe Arg Glu Gly Leu Tyr His Ile Val Asn 
    50                  55                  60                  

Val Glu Ala Asn Asp Asp Ala Ala Leu Lys Glu Phe Asp Arg Leu Ser 
65                  70                  75                  80  

Lys Ile Asn Ala Asp Ile Leu Arg His Met Ile Val Lys Ile Asp Ala 
                85                  90                  95      


<210>   3157
<211>   1341
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3157
atgacaaaac gtgtaacgat tattgacgta aaagactatg ttggtcagga agtgacgatt   60
ggcgcttggg ttgccaacaa atcaggaaaa ggaaaaatcg ctttcttaca attgcgtgat   120
ggaacagcct tctttcaagg tgtggctttt aaaccaaact ttgtcgaaaa atttggtgaa   180
gaagtgggac ttgagaagtt tgatgttatc aaacgcttga gccaagaaac gtctgtttat   240
gtgacaggta ttgtcaaaga ggacgaacgt tctaaatttg gctatgagtt ggacatcaca   300
gacatcgaag tgatcggtga atctcaagac tacccaatca caccaaaaga acacggaaca   360
gactttttga tggataaccg tcacttgtgg ctacgctctc gtaagcaagt agctgtgttg   420
caaatccgta acgctattat ctatgcaact tatgagttct ttgacaagaa cggttttatg   480
aagtttgaca gcccaattct ttcaggaaat gcggcagaag attctacaga actctttgaa   540
actgactact tcggaacgcc agcctacttg agccaatcag gtcagcttta cctagaagca   600
ggggctatgg ctcttggtcg tgtctttgac tttggtccag ttttccgtgc tgaaaaatca   660
aaaacacgcc gtcacttgac tgagttctgg atgatggatg ctgagtactc atacttgaca   720
catgatgagt cgcttgactt gcaagaagct tatgtgaaag ctcttctaca aggtgttctt   780
gaccgcgcgc ctcaagcctt ggaaaccttg gaacgtgata cagaactctt gaaacgctac   840
attgcagagc cattcaaacg tatcacttac gatcaagcca ttgacctctt gcaagagcat   900
gaaaatgatg aagatgctga ctacgagcat cttgagcatg gtgatgactt tgggtcacca   960
cacgaaactt ggatttcaaa ccactttggt gtgccaacat ttgtcatgaa ctatccagca   1020
gccatcaagg ccttctacat gaaaccagtt cctggaaatc cagagcgcgt gctttgtgca   1080
gacttgcttg ctccagaagg ctatggagaa attatcggtg ggtctatgcg tgaggaagat   1140
tacgatgccc ttgtcgctaa gatggatgaa cttggcatgg atcgtacaga atatgaattc   1200
taccttgacc ttcgtaaata cggtacagtt ccacacggag gatttggtat cggtatcgaa   1260
cgtatggtaa ccttcgcagc aggaacaaaa catatccgtg aagctattcc attcccacgt   1320
atgttgcacc gtatcaaacc a                                             1341

<210>   3158
<211>   447
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   asparaginyl-tRNA synthetase (asnS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903440 (0.E+01)

<400>   3158
Met Thr Lys Arg Val Thr Ile Ile Asp Val Lys Asp Tyr Val Gly Gln 
1               5                   10                  15      

Glu Val Thr Ile Gly Ala Trp Val Ala Asn Lys Ser Gly Lys Gly Lys 
            20                  25                  30          

Ile Ala Phe Leu Gln Leu Arg Asp Gly Thr Ala Phe Phe Gln Gly Val 
        35                  40                  45              

Ala Phe Lys Pro Asn Phe Val Glu Lys Phe Gly Glu Glu Val Gly Leu 
    50                  55                  60                  

Glu Lys Phe Asp Val Ile Lys Arg Leu Ser Gln Glu Thr Ser Val Tyr 
65                  70                  75                  80  

Val Thr Gly Ile Val Lys Glu Asp Glu Arg Ser Lys Phe Gly Tyr Glu 
                85                  90                  95      

Leu Asp Ile Thr Asp Ile Glu Val Ile Gly Glu Ser Gln Asp Tyr Pro 
            100                 105                 110         

Ile Thr Pro Lys Glu His Gly Thr Asp Phe Leu Met Asp Asn Arg His 
        115                 120                 125             

Leu Trp Leu Arg Ser Arg Lys Gln Val Ala Val Leu Gln Ile Arg Asn 
    130                 135                 140                 

Ala Ile Ile Tyr Ala Thr Tyr Glu Phe Phe Asp Lys Asn Gly Phe Met 
145                 150                 155                 160 

Lys Phe Asp Ser Pro Ile Leu Ser Gly Asn Ala Ala Glu Asp Ser Thr 
                165                 170                 175     

Glu Leu Phe Glu Thr Asp Tyr Phe Gly Thr Pro Ala Tyr Leu Ser Gln 
            180                 185                 190         

Ser Gly Gln Leu Tyr Leu Glu Ala Gly Ala Met Ala Leu Gly Arg Val 
        195                 200                 205             

Phe Asp Phe Gly Pro Val Phe Arg Ala Glu Lys Ser Lys Thr Arg Arg 
    210                 215                 220                 

His Leu Thr Glu Phe Trp Met Met Asp Ala Glu Tyr Ser Tyr Leu Thr 
225                 230                 235                 240 

His Asp Glu Ser Leu Asp Leu Gln Glu Ala Tyr Val Lys Ala Leu Leu 
                245                 250                 255     

Gln Gly Val Leu Asp Arg Ala Pro Gln Ala Leu Glu Thr Leu Glu Arg 
            260                 265                 270         

Asp Thr Glu Leu Leu Lys Arg Tyr Ile Ala Glu Pro Phe Lys Arg Ile 
        275                 280                 285             

Thr Tyr Asp Gln Ala Ile Asp Leu Leu Gln Glu His Glu Asn Asp Glu 
    290                 295                 300                 

Asp Ala Asp Tyr Glu His Leu Glu His Gly Asp Asp Phe Gly Ser Pro 
305                 310                 315                 320 

His Glu Thr Trp Ile Ser Asn His Phe Gly Val Pro Thr Phe Val Met 
                325                 330                 335     

Asn Tyr Pro Ala Ala Ile Lys Ala Phe Tyr Met Lys Pro Val Pro Gly 
            340                 345                 350         

Asn Pro Glu Arg Val Leu Cys Ala Asp Leu Leu Ala Pro Glu Gly Tyr 
        355                 360                 365             

Gly Glu Ile Ile Gly Gly Ser Met Arg Glu Glu Asp Tyr Asp Ala Leu 
    370                 375                 380                 

Val Ala Lys Met Asp Glu Leu Gly Met Asp Arg Thr Glu Tyr Glu Phe 
385                 390                 395                 400 

Tyr Leu Asp Leu Arg Lys Tyr Gly Thr Val Pro His Gly Gly Phe Gly 
                405                 410                 415     

Ile Gly Ile Glu Arg Met Val Thr Phe Ala Ala Gly Thr Lys His Ile 
            420                 425                 430         

Arg Glu Ala Ile Pro Phe Pro Arg Met Leu His Arg Ile Lys Pro 
        435                 440                 445         

<210>   3159
<211>   288
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   3159
ttggactata aattggcttt taagactagt tctctaatta gttttctatc cccgaacagc   60
cctcatcctg gtggtgattt ttggctgact cagggaacac aagatcctgt tcattttgct   120
tttttagcag aaaataagga agaagttcag gcttgttatg aggctggctt agaggcaggt   180
gggcgagaca atggggctcc tggttatcga agtgagcatc cgatttacta tgctgctttt   240
atgattgacc tggatgggaa caatatagag gtggtttgcc ataaagaa                288

<210>   3160
<211>   96
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, POINT MUTATION
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903441 (1.E-54)

<400>   3160
Met Asp Tyr Lys Leu Ala Phe Lys Thr Ser Ser Leu Ile Ser Phe Leu 
1               5                   10                  15      

Ser Pro Asn Ser Pro His Pro Gly Gly Asp Phe Trp Leu Thr Gln Gly 
            20                  25                  30          

Thr Gln Asp Pro Val His Phe Ala Phe Leu Ala Glu Asn Lys Glu Glu 
        35                  40                  45              

Val Gln Ala Cys Tyr Glu Ala Gly Leu Glu Ala Gly Gly Arg Asp Asn 
    50                  55                  60                  

Gly Ala Pro Gly Tyr Arg Ser Glu His Pro Ile Tyr Tyr Ala Ala Phe 
65                  70                  75                  80  

Met Ile Asp Leu Asp Gly Asn Asn Ile Glu Val Val Cys His Lys Glu 
                85                  90                  95      


<210>   3161
<211>   1185
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3161
atgaaactat ccaaccgtgt tttagaaatg gaagaaagtg tgactttggc tgctggagcc   60
cgtgccaaag cactgaaggc tgagggtaga gatattttgt ctctaacctt gggtgagcca   120
gatttcacta ctcccaaaaa tatccaagat gccgccattg catcgattcg agatgggcgt   180
gcttcttttt atacagtaac ctcaggtctg ccagagctta aggcggcggt caatagctac   240
tttgagcgct tttacggcta ttctgtagcg tcaaatcaag tgacagtcgc tgcgggagcc   300
aaatattctc tctatacctt ctttatggct gtggtcaatc caggtgatga agtcatcatc   360
ccaaccccat actgggttag ctatggagat caggtcaaga tggcagaagg cgttcccgtc   420
tttgtttctg ctaaggaaga caatcacttt aaggtgaccg tagagcagtt agaagcagct   480
cgcactgaca agaccaaggt tttggtgctg aattcgccat ctaatcccac aggtatgatt   540
tacacccgtg aggaactctt ggcaattgga aactgggctg tagaaaatga tattctcatc   600
ctagcagacg atatctatgg ccgcttggtt tataatggtc atgagttcac accgatttct   660
agcctatcgg aagcgattcg caagcaaaca gtggtcatca atggtgtgtc taaaacttat   720
gccatgactg gttggcggat tggttatgcc gttggagaag cagacattat cgctgccatg   780
tccaagattg caggtcaaac aacttcgaat ccgtcagcag tagcccaata tgcagcagtt   840
gaggctctat caggtgagca agatactgta gaaagcatgc gtcaggcctt tgaggaacgt   900
cttaatacca tctatcccct ccttgcagag gtaccaggat ttgaagtggt caaaccgcaa   960
ggggccttct atctcttccc aaatgtcaaa aaggccatgg agatgaaagg ctacacggat   1020
gtgacagact ttacaactgt tatcttagaa gaagccgaag tggccttggt aacaggagct   1080
ggatttggag caccagaaaa tgtccgcctc agctatgcga cagacctaga cacgcttaaa   1140
gaagcagtcg aacgcttgaa agcatttatg ggtagtgaga atgat                   1185

<210>   3162
<211>   395
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aspartate aminotransferase (aspC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903442 (0.E+01)

<400>   3162
Met Lys Leu Ser Asn Arg Val Leu Glu Met Glu Glu Ser Val Thr Leu 
1               5                   10                  15      

Ala Ala Gly Ala Arg Ala Lys Ala Leu Lys Ala Glu Gly Arg Asp Ile 
            20                  25                  30          

Leu Ser Leu Thr Leu Gly Glu Pro Asp Phe Thr Thr Pro Lys Asn Ile 
        35                  40                  45              

Gln Asp Ala Ala Ile Ala Ser Ile Arg Asp Gly Arg Ala Ser Phe Tyr 
    50                  55                  60                  

Thr Val Thr Ser Gly Leu Pro Glu Leu Lys Ala Ala Val Asn Ser Tyr 
65                  70                  75                  80  

Phe Glu Arg Phe Tyr Gly Tyr Ser Val Ala Ser Asn Gln Val Thr Val 
                85                  90                  95      

Ala Ala Gly Ala Lys Tyr Ser Leu Tyr Thr Phe Phe Met Ala Val Val 
            100                 105                 110         

Asn Pro Gly Asp Glu Val Ile Ile Pro Thr Pro Tyr Trp Val Ser Tyr 
        115                 120                 125             

Gly Asp Gln Val Lys Met Ala Glu Gly Val Pro Val Phe Val Ser Ala 
    130                 135                 140                 

Lys Glu Asp Asn His Phe Lys Val Thr Val Glu Gln Leu Glu Ala Ala 
145                 150                 155                 160 

Arg Thr Asp Lys Thr Lys Val Leu Val Leu Asn Ser Pro Ser Asn Pro 
                165                 170                 175     

Thr Gly Met Ile Tyr Thr Arg Glu Glu Leu Leu Ala Ile Gly Asn Trp 
            180                 185                 190         

Ala Val Glu Asn Asp Ile Leu Ile Leu Ala Asp Asp Ile Tyr Gly Arg 
        195                 200                 205             

Leu Val Tyr Asn Gly His Glu Phe Thr Pro Ile Ser Ser Leu Ser Glu 
    210                 215                 220                 

Ala Ile Arg Lys Gln Thr Val Val Ile Asn Gly Val Ser Lys Thr Tyr 
225                 230                 235                 240 

Ala Met Thr Gly Trp Arg Ile Gly Tyr Ala Val Gly Glu Ala Asp Ile 
                245                 250                 255     

Ile Ala Ala Met Ser Lys Ile Ala Gly Gln Thr Thr Ser Asn Pro Ser 
            260                 265                 270         

Ala Val Ala Gln Tyr Ala Ala Val Glu Ala Leu Ser Gly Glu Gln Asp 
        275                 280                 285             

Thr Val Glu Ser Met Arg Gln Ala Phe Glu Glu Arg Leu Asn Thr Ile 
    290                 295                 300                 

Tyr Pro Leu Leu Ala Glu Val Pro Gly Phe Glu Val Val Lys Pro Gln 
305                 310                 315                 320 

Gly Ala Phe Tyr Leu Phe Pro Asn Val Lys Lys Ala Met Glu Met Lys 
                325                 330                 335     

Gly Tyr Thr Asp Val Thr Asp Phe Thr Thr Val Ile Leu Glu Glu Ala 
            340                 345                 350         

Glu Val Ala Leu Val Thr Gly Ala Gly Phe Gly Ala Pro Glu Asn Val 
        355                 360                 365             

Arg Leu Ser Tyr Ala Thr Asp Leu Asp Thr Leu Lys Glu Ala Val Glu 
    370                 375                 380                 

Arg Leu Lys Ala Phe Met Gly Ser Glu Asn Asp 
385                 390                 395 

<210>   3163
<211>   486
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3163
gtgaaaaaaa gacaaaacaa agcaaaaaat aatctactgt ggcagtatgg tctagggatg   60
acgattttgt ttgtggttat cagtggttcc tttctgtata tggtttctct tagcatgaaa   120
ccctatcaaa cagctaaaag tgaaggagaa aaattagctc agcagtatgc aggattagag   180
caggctgatc aggttgattt atacaatggc ttggaatctt attacagcgt tcttggtcgt   240
aacaaacagc aagaagcgct tgctgtcctg attggtaaag atgaccataa gatttacgtt   300
tatcagctaa atcagggtgt ttcacaagaa aaagcagaaa cggtttctaa ggaaaaggga   360
gctggcgaga ttgacaagat aacctttggc cgttatcaag ataagccaat ctgggaagtt   420
aagtcaggat ctgattttta tctagtagat tttgaaacag gagcattggt caacaaggag   480
ggccta                                                              486

<210>   3164
<211>   162
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903443 (1.E-77)

<400>   3164
Met Lys Lys Arg Gln Asn Lys Ala Lys Asn Asn Leu Leu Trp Gln Tyr 
1               5                   10                  15      

Gly Leu Gly Met Thr Ile Leu Phe Val Val Ile Ser Gly Ser Phe Leu 
            20                  25                  30          

Tyr Met Val Ser Leu Ser Met Lys Pro Tyr Gln Thr Ala Lys Ser Glu 
        35                  40                  45              

Gly Glu Lys Leu Ala Gln Gln Tyr Ala Gly Leu Glu Gln Ala Asp Gln 
    50                  55                  60                  

Val Asp Leu Tyr Asn Gly Leu Glu Ser Tyr Tyr Ser Val Leu Gly Arg 
65                  70                  75                  80  

Asn Lys Gln Gln Glu Ala Leu Ala Val Leu Ile Gly Lys Asp Asp His 
                85                  90                  95      

Lys Ile Tyr Val Tyr Gln Leu Asn Gln Gly Val Ser Gln Glu Lys Ala 
            100                 105                 110         

Glu Thr Val Ser Lys Glu Lys Gly Ala Gly Glu Ile Asp Lys Ile Thr 
        115                 120                 125             

Phe Gly Arg Tyr Gln Asp Lys Pro Ile Trp Glu Val Lys Ser Gly Ser 
    130                 135                 140                 

Asp Phe Tyr Leu Val Asp Phe Glu Thr Gly Ala Leu Val Asn Lys Glu 
145                 150                 155                 160 

Gly Leu 
        

<210>   3165
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3165
ttgcaagttc ttttgttttg ttgtaatata ttttataaca acgagagagt tctcgaaatt   60
ttaagaaaaa ggagacacat catgtctaaa aaagtattat ttatcgtcgg atcactacgt   120
caaggttctt tcaaccacca aatggcgctc gaagctgaga aagcacttgc tggtaaagcg   180
gaagttagct accttgatta ttcagccctt cctctcttca gccaagattt ggaagttcca   240
acacatccag ctgtagctgc tgctcgtgaa gcagttctcg ttgcggatgc tatctggatt   300
ttctctccag tctacaactt ctctatccct ggtacagtga aaaacttgct tgactggcta   360
tctcgtgccc ttgacttgtc tgatacacgt ggcgtttctg cccttcaaga caagtttgtc   420
acagtatcat ctgtagccaa tgcagggcac gatcaacttt tcgctatcta caaagacctc   480
ttgccattta tccgtacaca aggcgttggt gatttcactg ctgcacgtgt taatgactct   540
gcctgggcag acggaaaatt ggttcttgaa gaaacagtcc taaactcact tgaaaaacaa   600
gctcaagact tggtcgaagc tatcaag                                       627

<210>   3166
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903445 (e-114)

<400>   3166
Met Gln Val Leu Leu Phe Cys Cys Asn Ile Phe Tyr Asn Asn Glu Arg 
1               5                   10                  15      

Val Leu Glu Ile Leu Arg Lys Arg Arg His Ile Met Ser Lys Lys Val 
            20                  25                  30          

Leu Phe Ile Val Gly Ser Leu Arg Gln Gly Ser Phe Asn His Gln Met 
        35                  40                  45              

Ala Leu Glu Ala Glu Lys Ala Leu Ala Gly Lys Ala Glu Val Ser Tyr 
    50                  55                  60                  

Leu Asp Tyr Ser Ala Leu Pro Leu Phe Ser Gln Asp Leu Glu Val Pro 
65                  70                  75                  80  

Thr His Pro Ala Val Ala Ala Ala Arg Glu Ala Val Leu Val Ala Asp 
                85                  90                  95      

Ala Ile Trp Ile Phe Ser Pro Val Tyr Asn Phe Ser Ile Pro Gly Thr 

            100                 105                 110         

Val Lys Asn Leu Leu Asp Trp Leu Ser Arg Ala Leu Asp Leu Ser Asp 
        115                 120                 125             

Thr Arg Gly Val Ser Ala Leu Gln Asp Lys Phe Val Thr Val Ser Ser 
    130                 135                 140                 

Val Ala Asn Ala Gly His Asp Gln Leu Phe Ala Ile Tyr Lys Asp Leu 
145                 150                 155                 160 

Leu Pro Phe Ile Arg Thr Gln Gly Val Gly Asp Phe Thr Ala Ala Arg 
                165                 170                 175     

Val Asn Asp Ser Ala Trp Ala Asp Gly Lys Leu Val Leu Glu Glu Thr 
            180                 185                 190         

Val Leu Asn Ser Leu Glu Lys Gln Ala Gln Asp Leu Val Glu Ala Ile 
        195                 200                 205             

Lys 
    

<210>   3167
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3167
gtgcttgatg ccttggctct ctattctgcc agtcaattgg agagtttcta caaggtatca   60
gctgagaaag cggcggaaga atttcaaaat atccaagctt tgaaaaggca aactgctcaa   120
cactatccag ccttgaaact ttttgatggg cttatgtacc gcaacattaa gagagataag   180
ctgaccgagg cggaacaaga ttatcttgaa aatcatgttt tcattacctc ggctttgtac   240
ggtgttgttc cagtcttgtc acccatggct cctcaccgtt tggatttttt gatgaaatta   300
aaagtcgctg gtaagacttt gaagagccat tggaaggcag cctatgatga aactctgaag   360
aaggaagaag tgattttctc tctcttgtca tcagagtttg agactgtatt ttctaaggaa   420
atcagagcaa agatggtgac cttcaaattc atggaggata gaggcggtca gctgaagatt   480
cactcaacta tctccaagaa agcgcgcggg gcctttctaa cagctttaat agaaaatcaa   540
gtacaaactg tgggggaagc acgtcgcttg aactttgctg gatttgttta ccgagaagat   600
ttgtcacaac cacagggatt ggtttttgta aaggaagta                          639

<210>   3168
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903448 (e-131)

<400>   3168
Met Leu Asp Ala Leu Ala Leu Tyr Ser Ala Ser Gln Leu Glu Ser Phe 
1               5                   10                  15      

Tyr Lys Val Ser Ala Glu Lys Ala Ala Glu Glu Phe Gln Asn Ile Gln 
            20                  25                  30          

Ala Leu Lys Arg Gln Thr Ala Gln His Tyr Pro Ala Leu Lys Leu Phe 
        35                  40                  45              

Asp Gly Leu Met Tyr Arg Asn Ile Lys Arg Asp Lys Leu Thr Glu Ala 
    50                  55                  60                  

Glu Gln Asp Tyr Leu Glu Asn His Val Phe Ile Thr Ser Ala Leu Tyr 
65                  70                  75                  80  

Gly Val Val Pro Val Leu Ser Pro Met Ala Pro His Arg Leu Asp Phe 
                85                  90                  95      

Leu Met Lys Leu Lys Val Ala Gly Lys Thr Leu Lys Ser His Trp Lys 
            100                 105                 110         

Ala Ala Tyr Asp Glu Thr Leu Lys Lys Glu Glu Val Ile Phe Ser Leu 
        115                 120                 125             

Leu Ser Ser Glu Phe Glu Thr Val Phe Ser Lys Glu Ile Arg Ala Lys 
    130                 135                 140                 

Met Val Thr Phe Lys Phe Met Glu Asp Arg Gly Gly Gln Leu Lys Ile 
145                 150                 155                 160 

His Ser Thr Ile Ser Lys Lys Ala Arg Gly Ala Phe Leu Thr Ala Leu 
                165                 170                 175     

Ile Glu Asn Gln Val Gln Thr Val Gly Glu Ala Arg Arg Leu Asn Phe 
            180                 185                 190         

Ala Gly Phe Val Tyr Arg Glu Asp Leu Ser Gln Pro Gln Gly Leu Val 
        195                 200                 205             

Phe Val Lys Glu Val 
    210             

<210>   3169
<211>   1593
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3169
atgaaacgaa tagtctttga acttattttt atcgcaacga cctggtatat ctttttaccg   60
ccccttaacc tgaccagctg ggaatttctc ttcttcctct gtgggcattt gttagttgtg   120
gcaatattat ttggctttgg caaggggata aaccttgtca aaacggttca tgtgcgccac   180
ggtaaggcgg aagctgcctt aaatcttgag ggtttcaaaa tcaatcggtt agggaaaatt   240
ctgttagctt cgattggagg aattcttctc ttggcagctt tggtttcctt ggtaacttcc   300
agcatgtttc aggctaaaaa ttatgccaat gtagtcacgg ttacggaaaa agactttact   360
gaatttccta agagtgacac cagtaaggtt cctatcctag atagaagtac tgctgaaaaa   420
attggagacc gctacttggg ttccctaacc gataaggtgt cgcaatacgt agcggcagat   480
acctataccc aattgacaat tgatgggaaa ccttatcggg tcacaccact agaatatgca   540
gaccctatca aatggtttaa caatcaagcc aagggaatcg gtgagtatat taaggtggac   600
atggtaactg gaaatgcgga tttggtggac ttgaagacac caatcaagta ttcagactcg   660
gagtatttta accgtgatgt caaacgtcac ctgcgcttga agtacccgac caaaatcttt   720
aaaactccat cttttgaggt ggacgatgag ggcaatcctt tctatgtagc aacggtttac   780
caaaagcaat ttggacttgc tgttcctcgt cctgcttcag tcattatctt ggatgctaca   840
aatggagaaa ccaaggaata cagcttatca gatgttccag aatgggtgga caggatctat   900
ccagcagagg aaaccattga gcaaatcaac tacaacggca agtacaagga cggtttcttg   960
aatgccatga tttccaagaa aaacgtgacc cagactacca atggctataa ttacttgtct   1020
atcggtaatg acatctatct ctacacaggt gtgacgtcgg ctaatgcgga tgagagtaat   1080
cttggtttca tccttgaaaa tatgcgaaca ggagaaatca ctaagtatag cttggcttct   1140
gcgacagaag aatcagcccg tgaatcagca gaaggtgctg ttcaggagaa atcctacaaa   1200
gcaaccttcc caatcctcat caacctcaat gacaagcctc tctacatcat gggcttgaag   1260
gacaatgctg gcttggtcaa agagtacgcc ctggtagacg cagtcgagta ccaaaatgtt   1320
atcgttgcta ctacagtgga agagatgctc agcaagtatg ccaataaaaa cgaccttgaa   1380
attgacaatg caacgacaga aagcatcaat ggagtagtag cagacctcaa atcagctgtt   1440
atcaagggag acactgtcta cttctttaaa gttgatggca agatatacaa ggtcaaggct   1500
tcagtatccg atgaccttcc ttaccttgaa aatggtaaaa ccttcgaagg tcaagtagga   1560
aaagacaatt atctcaagac ctttaagcta cgg                                1593

<210>   3170
<211>   531
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903450 (0.E+01)

<400>   3170
Met Lys Arg Ile Val Phe Glu Leu Ile Phe Ile Ala Thr Thr Trp Tyr 
1               5                   10                  15      

Ile Phe Leu Pro Pro Leu Asn Leu Thr Ser Trp Glu Phe Leu Phe Phe 
            20                  25                  30          

Leu Cys Gly His Leu Leu Val Val Ala Ile Leu Phe Gly Phe Gly Lys 
        35                  40                  45              

Gly Ile Asn Leu Val Lys Thr Val His Val Arg His Gly Lys Ala Glu 
    50                  55                  60                  

Ala Ala Leu Asn Leu Glu Gly Phe Lys Ile Asn Arg Leu Gly Lys Ile 
65                  70                  75                  80  

Leu Leu Ala Ser Ile Gly Gly Ile Leu Leu Leu Ala Ala Leu Val Ser 
                85                  90                  95      

Leu Val Thr Ser Ser Met Phe Gln Ala Lys Asn Tyr Ala Asn Val Val 
            100                 105                 110         

Thr Val Thr Glu Lys Asp Phe Thr Glu Phe Pro Lys Ser Asp Thr Ser 
        115                 120                 125             

Lys Val Pro Ile Leu Asp Arg Ser Thr Ala Glu Lys Ile Gly Asp Arg 
    130                 135                 140                 

Tyr Leu Gly Ser Leu Thr Asp Lys Val Ser Gln Tyr Val Ala Ala Asp 
145                 150                 155                 160 

Thr Tyr Thr Gln Leu Thr Ile Asp Gly Lys Pro Tyr Arg Val Thr Pro 
                165                 170                 175     

Leu Glu Tyr Ala Asp Pro Ile Lys Trp Phe Asn Asn Gln Ala Lys Gly 
            180                 185                 190         

Ile Gly Glu Tyr Ile Lys Val Asp Met Val Thr Gly Asn Ala Asp Leu 
        195                 200                 205             

Val Asp Leu Lys Thr Pro Ile Lys Tyr Ser Asp Ser Glu Tyr Phe Asn 
    210                 215                 220                 

Arg Asp Val Lys Arg His Leu Arg Leu Lys Tyr Pro Thr Lys Ile Phe 
225                 230                 235                 240 

Lys Thr Pro Ser Phe Glu Val Asp Asp Glu Gly Asn Pro Phe Tyr Val 
                245                 250                 255     

Ala Thr Val Tyr Gln Lys Gln Phe Gly Leu Ala Val Pro Arg Pro Ala 
            260                 265                 270         

Ser Val Ile Ile Leu Asp Ala Thr Asn Gly Glu Thr Lys Glu Tyr Ser 
        275                 280                 285             

Leu Ser Asp Val Pro Glu Trp Val Asp Arg Ile Tyr Pro Ala Glu Glu 
    290                 295                 300                 

Thr Ile Glu Gln Ile Asn Tyr Asn Gly Lys Tyr Lys Asp Gly Phe Leu 
305                 310                 315                 320 

Asn Ala Met Ile Ser Lys Lys Asn Val Thr Gln Thr Thr Asn Gly Tyr 
                325                 330                 335     

Asn Tyr Leu Ser Ile Gly Asn Asp Ile Tyr Leu Tyr Thr Gly Val Thr 
            340                 345                 350         

Ser Ala Asn Ala Asp Glu Ser Asn Leu Gly Phe Ile Leu Glu Asn Met 
        355                 360                 365             

Arg Thr Gly Glu Ile Thr Lys Tyr Ser Leu Ala Ser Ala Thr Glu Glu 
    370                 375                 380                 

Ser Ala Arg Glu Ser Ala Glu Gly Ala Val Gln Glu Lys Ser Tyr Lys 
385                 390                 395                 400 

Ala Thr Phe Pro Ile Leu Ile Asn Leu Asn Asp Lys Pro Leu Tyr Ile 
                405                 410                 415     

Met Gly Leu Lys Asp Asn Ala Gly Leu Val Lys Glu Tyr Ala Leu Val 
            420                 425                 430         

Asp Ala Val Glu Tyr Gln Asn Val Ile Val Ala Thr Thr Val Glu Glu 
        435                 440                 445             

Met Leu Ser Lys Tyr Ala Asn Lys Asn Asp Leu Glu Ile Asp Asn Ala 

    450                 455                 460                 

Thr Thr Glu Ser Ile Asn Gly Val Val Ala Asp Leu Lys Ser Ala Val 
465                 470                 475                 480 

Ile Lys Gly Asp Thr Val Tyr Phe Phe Lys Val Asp Gly Lys Ile Tyr 
                485                 490                 495     

Lys Val Lys Ala Ser Val Ser Asp Asp Leu Pro Tyr Leu Glu Asn Gly 
            500                 505                 510         

Lys Thr Phe Glu Gly Gln Val Gly Lys Asp Asn Tyr Leu Lys Thr Phe 
        515                 520                 525             

Lys Leu Arg 
    530     

<210>   3171
<211>   408
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3171
gtggaaaaga aaattgtgaa ggatatctta tttttatctc aagtgtctca gccggcaagt   60
caggaggacc tttatcttgc cagagatttg caggatacac tcttagcaaa tcgtgatacc   120
tgtgttggtc tagctgccaa tatgattggg gtgcagaagc gcgtgattat ctttaatctt   180
ggcttggttc ctgtggtcat gtttaaccca gtgcttctgt cctttgaagg atcctatgag   240
gcagaagaag gctgtttgtc cttggtaggt gtgagatcaa ctaagcgtta tgaaaccata   300
aggcttgcct atcgtgacag caagtggcag gaacagacca ttaccttgac aggcttccca   360
gctcagattt gccagcatga gctggatcac ttggaaggac gaatcatt                408

<210>   3172
<211>   136
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   polypeptide deformylase (def)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903451 (3.E-74)

<400>   3172
Met Glu Lys Lys Ile Val Lys Asp Ile Leu Phe Leu Ser Gln Val Ser 
1               5                   10                  15      

Gln Pro Ala Ser Gln Glu Asp Leu Tyr Leu Ala Arg Asp Leu Gln Asp 
            20                  25                  30          

Thr Leu Leu Ala Asn Arg Asp Thr Cys Val Gly Leu Ala Ala Asn Met 
        35                  40                  45              

Ile Gly Val Gln Lys Arg Val Ile Ile Phe Asn Leu Gly Leu Val Pro 
    50                  55                  60                  

Val Val Met Phe Asn Pro Val Leu Leu Ser Phe Glu Gly Ser Tyr Glu 
65                  70                  75                  80  

Ala Glu Glu Gly Cys Leu Ser Leu Val Gly Val Arg Ser Thr Lys Arg 
                85                  90                  95      

Tyr Glu Thr Ile Arg Leu Ala Tyr Arg Asp Ser Lys Trp Gln Glu Gln 
            100                 105                 110         

Thr Ile Thr Leu Thr Gly Phe Pro Ala Gln Ile Cys Gln His Glu Leu 
        115                 120                 125             

Asp His Leu Glu Gly Arg Ile Ile 
    130                 135     

<210>   3173
<211>   789
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3173
atgtcagcat atcaattacc gaccgtatgg caggatgaag ctagtaatca aggagctttt   60
acggggctaa acagaccaac agcaggtgcc cgtttcgaac aaaacttgcc aaaaggagaa   120
caagcttttc agctttattc actgggaaca ccaaatggtg tgaaggttac tatcttattg   180
gaagaattac tagaagctgg ttttaaggaa gcggcttacg acttgtataa gattgctatc   240
atggatgggg atcaattcgg atcagacttt gtgaagctca atccaaattc caagattcca   300
gccttattgg accagtcagg tactgaaaac gtaagagtct ttgagtctgc tcatattctt   360
ctttaccttg ctgagaaatt tggagccttt ttaccaagta atcctgtgga aaaggtagaa   420
gttttgaatt ggctattctg gcaagcaggt gcagcacctt ttctaggtgg gggatttgga   480
catttcttca attatgctcc tgaaaaattg gaatatccta ttaaccgttt tacgatggaa   540
gtgaaacgcc agttggattt attggataag gaattggctc agaaacctta tattgcaggc   600
aatgactata cgattgcaga tattgctatc tggtcttggt atggacagtt agttcaagga   660
aatctttacc aaggttctgc aaaattcttg gatgcctcaa gttatcaaaa tctagtaaaa   720
tgggcagaaa aaattgccaa tcgtccagct gttaagcgtg gcttggaagt aacttataca   780
gaaattaaa                                                           789

<210>   3174
<211>   263
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutathione S-transferase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903452 (e-153)

<400>   3174
Met Ser Ala Tyr Gln Leu Pro Thr Val Trp Gln Asp Glu Ala Ser Asn 
1               5                   10                  15      

Gln Gly Ala Phe Thr Gly Leu Asn Arg Pro Thr Ala Gly Ala Arg Phe 
            20                  25                  30          

Glu Gln Asn Leu Pro Lys Gly Glu Gln Ala Phe Gln Leu Tyr Ser Leu 
        35                  40                  45              

Gly Thr Pro Asn Gly Val Lys Val Thr Ile Leu Leu Glu Glu Leu Leu 
    50                  55                  60                  

Glu Ala Gly Phe Lys Glu Ala Ala Tyr Asp Leu Tyr Lys Ile Ala Ile 
65                  70                  75                  80  

Met Asp Gly Asp Gln Phe Gly Ser Asp Phe Val Lys Leu Asn Pro Asn 
                85                  90                  95      

Ser Lys Ile Pro Ala Leu Leu Asp Gln Ser Gly Thr Glu Asn Val Arg 
            100                 105                 110         

Val Phe Glu Ser Ala His Ile Leu Leu Tyr Leu Ala Glu Lys Phe Gly 
        115                 120                 125             

Ala Phe Leu Pro Ser Asn Pro Val Glu Lys Val Glu Val Leu Asn Trp 
    130                 135                 140                 

Leu Phe Trp Gln Ala Gly Ala Ala Pro Phe Leu Gly Gly Gly Phe Gly 
145                 150                 155                 160 

His Phe Phe Asn Tyr Ala Pro Glu Lys Leu Glu Tyr Pro Ile Asn Arg 
                165                 170                 175     

Phe Thr Met Glu Val Lys Arg Gln Leu Asp Leu Leu Asp Lys Glu Leu 
            180                 185                 190         

Ala Gln Lys Pro Tyr Ile Ala Gly Asn Asp Tyr Thr Ile Ala Asp Ile 
        195                 200                 205             

Ala Ile Trp Ser Trp Tyr Gly Gln Leu Val Gln Gly Asn Leu Tyr Gln 
    210                 215                 220                 

Gly Ser Ala Lys Phe Leu Asp Ala Ser Ser Tyr Gln Asn Leu Val Lys 
225                 230                 235                 240 

Trp Ala Glu Lys Ile Ala Asn Arg Pro Ala Val Lys Arg Gly Leu Glu 
                245                 250                 255     

Val Thr Tyr Thr Glu Ile Lys 
            260             

<210>   3175
<211>   2694
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3175
atgtcaaaag aacaaaaacg ccaagcgttt tatactcaga gccctgaaga ggtcttgcag   60
gctgtggatg cgaccgagca aggtttgtca tcaagtgagg cggaaaagcg ccttgccgaa   120
tttgggcaca atgaactcga agaaggcgag aaacgatcaa tcttggtcaa attcatcgag   180
caatttaagg atttgatgat tatcatccta gttgcggcag caatcttgtc agtcgtgact   240
tctggtgggg aagatatcgc agatgccatt atcatcctag ctgtggttat catcaacgct   300
gcctttggtg tttaccaaga aggaaaagct gaagaagcta ttgaagccct caaatccatg   360
tctagtccag ttgcccgcgt tcttcgtgat ggacacatgg cagagattga ctctaaagaa   420
ttggtaccag gcgatatcgt tgcccttgaa gcaggtgacg tggtaccagc ggacctacgt   480
ttgatagaag ccaactctct taaaattgaa gaagcagcct tgacaggtga atctgtacca   540
gtcgaaaaag acttgtcagt cgagcttgcg acagatgctg gtattggtga ccgtgtcaac   600
atggccttcc aaaactcaaa cgtaacctat ggtcgtggga tgggtgttgt tgtcaataca   660
ggtatgtaca ctgaagttgg tcatattgct ggtatgcttc aagatgcgga tgagactgat   720
acaccactca aacaaaattt gaacaacctt tctaaggtct tgacctatgc tatcttggtc   780
attgcccttg ttacttttgt agtgggtgtc ttcattcaag ggaaaaatcc acttggtgag   840
ttgttgactt ctgttgccct tgccgttgca gccattccag aaggacttcc tgctatcgtt   900
accatcgttc tttctcttgg tactcaagtt ttggccaaac gacattccat cgttcgtaag   960
ttgccagcag ttgaaacact tggttcaact gaaatcatcg cttctgataa gactggtacg   1020
ctgactatga acaagatgac agtcgaaaaa gtcttctacg atgcggttct acatgactca   1080
gctgatgata ttgaactagg tcttgaaatg ccactacttc gttcagttgt cttggccaat   1140
gatacgaaaa tcgatgtgga aggtaacttg attggtgacc caaccgaaac agcctttatc   1200
caatatgcct tggacaaggg ctatgatgtc aaaggtttct tagagaaata tcctcgtgta   1260
gctgaattgc catttgactc tgaccgtaag ctcatgtcaa cagttcaccc attgccagat   1320
ggtcgtttcc ttgtagcagt caagggtgcg ccagaccaac tcttaaaacg ttgtcttctt   1380
cgtgataagg ctggggatat tgctccgatt gatgagaagg ttacaaatct cattcgtaca   1440
aacaattctg aaatggctca tcaagccttg cgtgtccttg caggtgctta taagattatc   1500
gatagtattc cagaaaatct cacttctgaa gagcttgaaa atgatttaat ttttactggt   1560
ttgattggga tgattgaccc tgaacgtcct gaagccgctg aggctgttcg tgtggctaag   1620
gaagcgggaa tccgtccaat tatgattaca ggtgaccacc aagacacagc ggaagccatt   1680
gccaaacgtt tgggaatcat tgacgcaaac gatacagaag gtcacgtttt aactggtgct   1740
gaactcaatg aactgtcaga tgaagaattt gaaaaagtcg ttggtcaata ctctgtttat   1800
gcccgtgtgt ctccagaaca caaggttcgt atcgtcaagg cttggcaaaa acaaggtaaa   1860
gtcgttgcca tgacaggtga cggtgtcaat gacgcgccag ctctgaaaac agccgatatc   1920
ggtatcggta tgggaatcac tggtacagag gtttctaagg gggcttctga tatgattctt   1980
gcagatgata actttgcgac tattatcgtc gcagtggaag aaggacgtaa ggtcttctca   2040
aacattcaaa agactattca gtacctactt tctgctaata ctgctgaagt attaaccatc   2100
ttcctatcaa ccttgtttgg ttgggatgtc ttacagccgg ttcatctttt gtggatcaac   2160
ttggtaacgg ataccttccc agctatcgct cttggtgttg aacctgcgga acctggtgtc   2220
atgaatcata aaccacgtgg acgcaaggca agcttcttct caggtggtgt tttgagttct   2280
atcatttatc aaggtgtact ccaagcagct cttgttatga gtgtttatgg ccttgcgatt   2340
gcttacccag ttcatgtggg tgacaatcat gctattcatg cagatgccct aacgatggcc   2400
tttgcaaccc ttggtttgat tcagctcttc catgcctaca atgtcaagtc tgtctaccaa   2460
tccatcttga cagttggccc attcaagtct aagaccttta actggtccat cttggtatcc   2520
tttatccttc tcatggcaac aatcgttgta gaaccgcttg aaggaatctt ccacgtaacc   2580
aaactagact tgtcacaatg gggaattgtt atggctggaa gcttctcaat gattatcatc   2640
gtcgaaatcg ttaagtttat tcaacgcaaa ctcggttttg acaagaatgc gatt         2694

<210>   3176
<211>   898
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cation-transporting ATPase, E1-E2 family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903453 (0.E+01)

<400>   3176
Met Ser Lys Glu Gln Lys Arg Gln Ala Phe Tyr Thr Gln Ser Pro Glu 
1               5                   10                  15      

Glu Val Leu Gln Ala Val Asp Ala Thr Glu Gln Gly Leu Ser Ser Ser 
            20                  25                  30          

Glu Ala Glu Lys Arg Leu Ala Glu Phe Gly His Asn Glu Leu Glu Glu 
        35                  40                  45              

Gly Glu Lys Arg Ser Ile Leu Val Lys Phe Ile Glu Gln Phe Lys Asp 
    50                  55                  60                  

Leu Met Ile Ile Ile Leu Val Ala Ala Ala Ile Leu Ser Val Val Thr 
65                  70                  75                  80  

Ser Gly Gly Glu Asp Ile Ala Asp Ala Ile Ile Ile Leu Ala Val Val 
                85                  90                  95      

Ile Ile Asn Ala Ala Phe Gly Val Tyr Gln Glu Gly Lys Ala Glu Glu 
            100                 105                 110         

Ala Ile Glu Ala Leu Lys Ser Met Ser Ser Pro Val Ala Arg Val Leu 
        115                 120                 125             

Arg Asp Gly His Met Ala Glu Ile Asp Ser Lys Glu Leu Val Pro Gly 
    130                 135                 140                 

Asp Ile Val Ala Leu Glu Ala Gly Asp Val Val Pro Ala Asp Leu Arg 
145                 150                 155                 160 

Leu Ile Glu Ala Asn Ser Leu Lys Ile Glu Glu Ala Ala Leu Thr Gly 
                165                 170                 175     

Glu Ser Val Pro Val Glu Lys Asp Leu Ser Val Glu Leu Ala Thr Asp 
            180                 185                 190         

Ala Gly Ile Gly Asp Arg Val Asn Met Ala Phe Gln Asn Ser Asn Val 
        195                 200                 205             

Thr Tyr Gly Arg Gly Met Gly Val Val Val Asn Thr Gly Met Tyr Thr 
    210                 215                 220                 

Glu Val Gly His Ile Ala Gly Met Leu Gln Asp Ala Asp Glu Thr Asp 
225                 230                 235                 240 

Thr Pro Leu Lys Gln Asn Leu Asn Asn Leu Ser Lys Val Leu Thr Tyr 
                245                 250                 255     

Ala Ile Leu Val Ile Ala Leu Val Thr Phe Val Val Gly Val Phe Ile 
            260                 265                 270         

Gln Gly Lys Asn Pro Leu Gly Glu Leu Leu Thr Ser Val Ala Leu Ala 
        275                 280                 285             

Val Ala Ala Ile Pro Glu Gly Leu Pro Ala Ile Val Thr Ile Val Leu 
    290                 295                 300                 

Ser Leu Gly Thr Gln Val Leu Ala Lys Arg His Ser Ile Val Arg Lys 
305                 310                 315                 320 

Leu Pro Ala Val Glu Thr Leu Gly Ser Thr Glu Ile Ile Ala Ser Asp 
                325                 330                 335     

Lys Thr Gly Thr Leu Thr Met Asn Lys Met Thr Val Glu Lys Val Phe 
            340                 345                 350         

Tyr Asp Ala Val Leu His Asp Ser Ala Asp Asp Ile Glu Leu Gly Leu 
        355                 360                 365             

Glu Met Pro Leu Leu Arg Ser Val Val Leu Ala Asn Asp Thr Lys Ile 
    370                 375                 380                 

Asp Val Glu Gly Asn Leu Ile Gly Asp Pro Thr Glu Thr Ala Phe Ile 
385                 390                 395                 400 

Gln Tyr Ala Leu Asp Lys Gly Tyr Asp Val Lys Gly Phe Leu Glu Lys 
                405                 410                 415     

Tyr Pro Arg Val Ala Glu Leu Pro Phe Asp Ser Asp Arg Lys Leu Met 
            420                 425                 430         

Ser Thr Val His Pro Leu Pro Asp Gly Arg Phe Leu Val Ala Val Lys 
        435                 440                 445             

Gly Ala Pro Asp Gln Leu Leu Lys Arg Cys Leu Leu Arg Asp Lys Ala 
    450                 455                 460                 

Gly Asp Ile Ala Pro Ile Asp Glu Lys Val Thr Asn Leu Ile Arg Thr 
465                 470                 475                 480 

Asn Asn Ser Glu Met Ala His Gln Ala Leu Arg Val Leu Ala Gly Ala 
                485                 490                 495     

Tyr Lys Ile Ile Asp Ser Ile Pro Glu Asn Leu Thr Ser Glu Glu Leu 
            500                 505                 510         

Glu Asn Asp Leu Ile Phe Thr Gly Leu Ile Gly Met Ile Asp Pro Glu 
        515                 520                 525             

Arg Pro Glu Ala Ala Glu Ala Val Arg Val Ala Lys Glu Ala Gly Ile 
    530                 535                 540                 

Arg Pro Ile Met Ile Thr Gly Asp His Gln Asp Thr Ala Glu Ala Ile 
545                 550                 555                 560 

Ala Lys Arg Leu Gly Ile Ile Asp Ala Asn Asp Thr Glu Gly His Val 
                565                 570                 575     

Leu Thr Gly Ala Glu Leu Asn Glu Leu Ser Asp Glu Glu Phe Glu Lys 
            580                 585                 590         

Val Val Gly Gln Tyr Ser Val Tyr Ala Arg Val Ser Pro Glu His Lys 
        595                 600                 605             

Val Arg Ile Val Lys Ala Trp Gln Lys Gln Gly Lys Val Val Ala Met 
    610                 615                 620                 

Thr Gly Asp Gly Val Asn Asp Ala Pro Ala Leu Lys Thr Ala Asp Ile 
625                 630                 635                 640 

Gly Ile Gly Met Gly Ile Thr Gly Thr Glu Val Ser Lys Gly Ala Ser 
                645                 650                 655     

Asp Met Ile Leu Ala Asp Asp Asn Phe Ala Thr Ile Ile Val Ala Val 
            660                 665                 670         

Glu Glu Gly Arg Lys Val Phe Ser Asn Ile Gln Lys Thr Ile Gln Tyr 
        675                 680                 685             

Leu Leu Ser Ala Asn Thr Ala Glu Val Leu Thr Ile Phe Leu Ser Thr 
    690                 695                 700                 

Leu Phe Gly Trp Asp Val Leu Gln Pro Val His Leu Leu Trp Ile Asn 
705                 710                 715                 720 

Leu Val Thr Asp Thr Phe Pro Ala Ile Ala Leu Gly Val Glu Pro Ala 
                725                 730                 735     

Glu Pro Gly Val Met Asn His Lys Pro Arg Gly Arg Lys Ala Ser Phe 
            740                 745                 750         

Phe Ser Gly Gly Val Leu Ser Ser Ile Ile Tyr Gln Gly Val Leu Gln 
        755                 760                 765             

Ala Ala Leu Val Met Ser Val Tyr Gly Leu Ala Ile Ala Tyr Pro Val 
    770                 775                 780                 

His Val Gly Asp Asn His Ala Ile His Ala Asp Ala Leu Thr Met Ala 
785                 790                 795                 800 

Phe Ala Thr Leu Gly Leu Ile Gln Leu Phe His Ala Tyr Asn Val Lys 
                805                 810                 815     

Ser Val Tyr Gln Ser Ile Leu Thr Val Gly Pro Phe Lys Ser Lys Thr 
            820                 825                 830         

Phe Asn Trp Ser Ile Leu Val Ser Phe Ile Leu Leu Met Ala Thr Ile 
        835                 840                 845             

Val Val Glu Pro Leu Glu Gly Ile Phe His Val Thr Lys Leu Asp Leu 
    850                 855                 860                 

Ser Gln Trp Gly Ile Val Met Ala Gly Ser Phe Ser Met Ile Ile Ile 
865                 870                 875                 880 

Val Glu Ile Val Lys Phe Ile Gln Arg Lys Leu Gly Phe Asp Lys Asn 
                885                 890                 895     

Ala Ile 
        

<210>   3177
<211>   1182
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3177
atgaagcaat ctatctcaaa tctcaagtta gctgagcgtg gagccattat cagtatttcg   60
acctatttga tcttgtctgc agccaaatta gcagctggtc atctccttca ttcatccagt   120
ttggtggccg atggttttaa taacgtatcg gacatcattg gaaatgtggc cctcttaatc   180
gggattcgga tggcgcgcca gcctgcagac cgtgaccacc gttttggtca ttggaagatt   240
gaagatttgg caagcttgat cacttctatc atcatgttct atgtcggttt cgatgttcta   300
agagatacca ttcaaaagat tctcagtcgg gaagaaacgg tcattgatcc tcttggtgca   360
actctaggaa tcatttctgc agcgattatg tttgtggtct atctctacaa tactcgcctc   420
agtaagaaat ccaactccaa tgcgctgaag gcagctgcta aggacaatct ttctgacgct   480
gttacctcac ttggaaccgc cattgccatc ctagctagta gtttcaatta tccgattgtg   540
gataaactgg ttgctatcat catcactttc tttatcttga agactgccta tgatatcttc   600
atcgagtctt cctttagtct ttcagatggc tttgacgacc gcctgctcga ggactaccaa   660
aaggctatca tggaaattcc caaaatcagc aaggtcaaat cgcaaagagg tcgcacctac   720
ggtagcaaca tctacctgga tattacacta gagatgaatc ctgacttgtc tgtttttgaa   780
agccatgaaa tcgcggatca ggtcgagtct atgctggagg agcgttttgg cgtctttgat   840
accgatgtcc atatcgaacc agcacctatc cctgaggatg aaattttaga caatgtctat   900
aaaaaattgc ttatgcgtga acaattgatt gaccaaggaa accaactaga agaactcttg   960
actgatgatt ttgtctatat tcgccaagat ggagagcaga tggataaaga ggcttataag   1020
accaaaaaag agttaaattc tgctatcaag gacattcaaa ttacttccat cagtcaaaaa   1080
accaaactca tctgctatga gttagatggt atcatccata ccagtatctg gcgtcgccac   1140
gaaacctggc aaaatatctt tcatcaagaa accaaaaaag aa                      1182

<210>   3178
<211>   394
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cation efflux family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903454 (0.E+01)

<400>   3178
Met Lys Gln Ser Ile Ser Asn Leu Lys Leu Ala Glu Arg Gly Ala Ile 
1               5                   10                  15      

Ile Ser Ile Ser Thr Tyr Leu Ile Leu Ser Ala Ala Lys Leu Ala Ala 
            20                  25                  30          

Gly His Leu Leu His Ser Ser Ser Leu Val Ala Asp Gly Phe Asn Asn 
        35                  40                  45              

Val Ser Asp Ile Ile Gly Asn Val Ala Leu Leu Ile Gly Ile Arg Met 
    50                  55                  60                  

Ala Arg Gln Pro Ala Asp Arg Asp His Arg Phe Gly His Trp Lys Ile 
65                  70                  75                  80  

Glu Asp Leu Ala Ser Leu Ile Thr Ser Ile Ile Met Phe Tyr Val Gly 
                85                  90                  95      

Phe Asp Val Leu Arg Asp Thr Ile Gln Lys Ile Leu Ser Arg Glu Glu 
            100                 105                 110         

Thr Val Ile Asp Pro Leu Gly Ala Thr Leu Gly Ile Ile Ser Ala Ala 
        115                 120                 125             

Ile Met Phe Val Val Tyr Leu Tyr Asn Thr Arg Leu Ser Lys Lys Ser 
    130                 135                 140                 

Asn Ser Asn Ala Leu Lys Ala Ala Ala Lys Asp Asn Leu Ser Asp Ala 
145                 150                 155                 160 

Val Thr Ser Leu Gly Thr Ala Ile Ala Ile Leu Ala Ser Ser Phe Asn 
                165                 170                 175     

Tyr Pro Ile Val Asp Lys Leu Val Ala Ile Ile Ile Thr Phe Phe Ile 
            180                 185                 190         

Leu Lys Thr Ala Tyr Asp Ile Phe Ile Glu Ser Ser Phe Ser Leu Ser 
        195                 200                 205             

Asp Gly Phe Asp Asp Arg Leu Leu Glu Asp Tyr Gln Lys Ala Ile Met 
    210                 215                 220                 

Glu Ile Pro Lys Ile Ser Lys Val Lys Ser Gln Arg Gly Arg Thr Tyr 
225                 230                 235                 240 

Gly Ser Asn Ile Tyr Leu Asp Ile Thr Leu Glu Met Asn Pro Asp Leu 
                245                 250                 255     

Ser Val Phe Glu Ser His Glu Ile Ala Asp Gln Val Glu Ser Met Leu 
            260                 265                 270         

Glu Glu Arg Phe Gly Val Phe Asp Thr Asp Val His Ile Glu Pro Ala 
        275                 280                 285             

Pro Ile Pro Glu Asp Glu Ile Leu Asp Asn Val Tyr Lys Lys Leu Leu 
    290                 295                 300                 

Met Arg Glu Gln Leu Ile Asp Gln Gly Asn Gln Leu Glu Glu Leu Leu 
305                 310                 315                 320 

Thr Asp Asp Phe Val Tyr Ile Arg Gln Asp Gly Glu Gln Met Asp Lys 

                325                 330                 335     

Glu Ala Tyr Lys Thr Lys Lys Glu Leu Asn Ser Ala Ile Lys Asp Ile 
            340                 345                 350         

Gln Ile Thr Ser Ile Ser Gln Lys Thr Lys Leu Ile Cys Tyr Glu Leu 
        355                 360                 365             

Asp Gly Ile Ile His Thr Ser Ile Trp Arg Arg His Glu Thr Trp Gln 
    370                 375                 380                 

Asn Ile Phe His Gln Glu Thr Lys Lys Glu 

385                 390                 

<210>   3179
<211>   1869
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3179
atgagtgatt ttatcgttga aaaactaagt aaatccgttg gtgacaagac cgtttttagg   60
gatatttcct ttattatcca tgacttagac agaattggtt taatcggtgt caatgggact   120
ggcaagacca cccttttgga cgtcctttct ggtgtttctg gatttgatgg ggatgtcagt   180
cctttttcag ctaaaaatga ttaccagatt ggttacttga ctcaggatcc tgattttgat   240
gatagaaaga cagttttgga tacggttcta tctagtgaac tcaaggaaat ccagctcatt   300
cgtgagtatg aattgattat gctcgactat agtgaggaca agcaggcgcg tttggaacgt   360
gtcatggcag agatggactc tctccaagct tgggaaatcg aaagtcaggt caagaccgtt   420
cttagcaaat tgggcattca agacttatct actcctgttg gggaattgtc aggtggtctg   480
agaagacggg tacagttggc acaagtctta cttggcaacc acgacctctt gcttttggat   540
gagccgacca accatctgga tattgcgatt attgagtggc tgaccctctt tttgaaaaat   600
tctaagaaga ccgtcctttt tatcactcac gatcgttatt tcttagacgc tttgtcaaca   660
cggattttcg agttggatcg tgcaggcttg accgagtacc agggaaatta ccaggactat   720
gttcgcctaa aggcggaaca ggatgagcgc gacgcggctc ttcttcacaa aaaagaacaa   780
ctctacaaac aagaattggc ctggatgcgc agacaaccgc aggcgcgtgc gaccaagcaa   840
caagctcgta tcaatcgttt ccatgatctg aaaaaggaag tttcaggcag tagtgctgag   900
acagacttga ctatgaactt tgaaaccagt cggattggga agaaagtcat cgagtttcag   960
gatgtttcct ttgcctatga aaataagccc attttgcaaa attttaatct cttagttcag   1020
gctaaagacc gtattggaat tgttggggac aatggtgttg gaaaatcaac cctacttaac   1080
ctgattgcag gaagtcttga gccgacagca ggacaagttg tgattgggga aactgttcgc   1140
atcgcctatt tctctcaaca aattgagggt ttggatgaaa gcaagcgtgt gatcaattac   1200
ctgcaggaag tggcagagga ggtcaagacc agtggtggtt ctacgacttc catcgctgag   1260
ttgctggagc aattcctctt cccacgttcg acgcatggga ctttgattga gaaattgtca   1320
gggggtgaga aaaaacgtct ttatctcctc aaactgcttt tggaaaaacc aaatgttctt   1380
cttttagacg agccaaccaa tgacctagat attgcaactt tgacagtctt agagaatttc   1440
ttgcaaggtt ttgcaggtcc cgttttaaca gtcagtcacg accgctattt cttggataag   1500
gtagcgacca agattctcgc ttttgaggat ggcaagattc gtcctttctt tggtcattac   1560
accgactatc ttgatgaaaa agcttttgaa acagatatgg ccaatcaagt gcaaaaggcc   1620
gaaaaggaaa aagtggtcaa ggttcgagaa gacaagaaac gcatgaccta ccaagaaaag   1680
caggagtggg caagtattga aggtgatatt gaaaccttgg aaaaacgtat cgctgctatt   1740
gaagaggaaa tgcaggctaa cggctctgac tttggtaagc tggctactct ccaaaaagaa   1800
ttggatgaga aaaatgaagc actccttgaa aaatacgaac gctatgagta tctcagtgaa   1860
tttgatagt                                                           1869

<210>   3180
<211>   623
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903455 (0.E+01)

<400>   3180
Met Ser Asp Phe Ile Val Glu Lys Leu Ser Lys Ser Val Gly Asp Lys 
1               5                   10                  15      

Thr Val Phe Arg Asp Ile Ser Phe Ile Ile His Asp Leu Asp Arg Ile 
            20                  25                  30          

Gly Leu Ile Gly Val Asn Gly Thr Gly Lys Thr Thr Leu Leu Asp Val 
        35                  40                  45              

Leu Ser Gly Val Ser Gly Phe Asp Gly Asp Val Ser Pro Phe Ser Ala 
    50                  55                  60                  

Lys Asn Asp Tyr Gln Ile Gly Tyr Leu Thr Gln Asp Pro Asp Phe Asp 
65                  70                  75                  80  

Asp Arg Lys Thr Val Leu Asp Thr Val Leu Ser Ser Glu Leu Lys Glu 
                85                  90                  95      

Ile Gln Leu Ile Arg Glu Tyr Glu Leu Ile Met Leu Asp Tyr Ser Glu 
            100                 105                 110         

Asp Lys Gln Ala Arg Leu Glu Arg Val Met Ala Glu Met Asp Ser Leu 
        115                 120                 125             

Gln Ala Trp Glu Ile Glu Ser Gln Val Lys Thr Val Leu Ser Lys Leu 
    130                 135                 140                 

Gly Ile Gln Asp Leu Ser Thr Pro Val Gly Glu Leu Ser Gly Gly Leu 
145                 150                 155                 160 

Arg Arg Arg Val Gln Leu Ala Gln Val Leu Leu Gly Asn His Asp Leu 
                165                 170                 175     

Leu Leu Leu Asp Glu Pro Thr Asn His Leu Asp Ile Ala Ile Ile Glu 
            180                 185                 190         

Trp Leu Thr Leu Phe Leu Lys Asn Ser Lys Lys Thr Val Leu Phe Ile 
        195                 200                 205             

Thr His Asp Arg Tyr Phe Leu Asp Ala Leu Ser Thr Arg Ile Phe Glu 
    210                 215                 220                 

Leu Asp Arg Ala Gly Leu Thr Glu Tyr Gln Gly Asn Tyr Gln Asp Tyr 
225                 230                 235                 240 

Val Arg Leu Lys Ala Glu Gln Asp Glu Arg Asp Ala Ala Leu Leu His 
                245                 250                 255     

Lys Lys Glu Gln Leu Tyr Lys Gln Glu Leu Ala Trp Met Arg Arg Gln 
            260                 265                 270         

Pro Gln Ala Arg Ala Thr Lys Gln Gln Ala Arg Ile Asn Arg Phe His 
        275                 280                 285             

Asp Leu Lys Lys Glu Val Ser Gly Ser Ser Ala Glu Thr Asp Leu Thr 
    290                 295                 300                 

Met Asn Phe Glu Thr Ser Arg Ile Gly Lys Lys Val Ile Glu Phe Gln 
305                 310                 315                 320 

Asp Val Ser Phe Ala Tyr Glu Asn Lys Pro Ile Leu Gln Asn Phe Asn 
                325                 330                 335     

Leu Leu Val Gln Ala Lys Asp Arg Ile Gly Ile Val Gly Asp Asn Gly 
            340                 345                 350         

Val Gly Lys Ser Thr Leu Leu Asn Leu Ile Ala Gly Ser Leu Glu Pro 
        355                 360                 365             

Thr Ala Gly Gln Val Val Ile Gly Glu Thr Val Arg Ile Ala Tyr Phe 
    370                 375                 380                 

Ser Gln Gln Ile Glu Gly Leu Asp Glu Ser Lys Arg Val Ile Asn Tyr 
385                 390                 395                 400 

Leu Gln Glu Val Ala Glu Glu Val Lys Thr Ser Gly Gly Ser Thr Thr 
                405                 410                 415     

Ser Ile Ala Glu Leu Leu Glu Gln Phe Leu Phe Pro Arg Ser Thr His 
            420                 425                 430         

Gly Thr Leu Ile Glu Lys Leu Ser Gly Gly Glu Lys Lys Arg Leu Tyr 
        435                 440                 445             

Leu Leu Lys Leu Leu Leu Glu Lys Pro Asn Val Leu Leu Leu Asp Glu 
    450                 455                 460                 

Pro Thr Asn Asp Leu Asp Ile Ala Thr Leu Thr Val Leu Glu Asn Phe 
465                 470                 475                 480 

Leu Gln Gly Phe Ala Gly Pro Val Leu Thr Val Ser His Asp Arg Tyr 
                485                 490                 495     

Phe Leu Asp Lys Val Ala Thr Lys Ile Leu Ala Phe Glu Asp Gly Lys 
            500                 505                 510         

Ile Arg Pro Phe Phe Gly His Tyr Thr Asp Tyr Leu Asp Glu Lys Ala 
        515                 520                 525             

Phe Glu Thr Asp Met Ala Asn Gln Val Gln Lys Ala Glu Lys Glu Lys 
    530                 535                 540                 

Val Val Lys Val Arg Glu Asp Lys Lys Arg Met Thr Tyr Gln Glu Lys 
545                 550                 555                 560 

Gln Glu Trp Ala Ser Ile Glu Gly Asp Ile Glu Thr Leu Glu Lys Arg 
                565                 570                 575     

Ile Ala Ala Ile Glu Glu Glu Met Gln Ala Asn Gly Ser Asp Phe Gly 
            580                 585                 590         

Lys Leu Ala Thr Leu Gln Lys Glu Leu Asp Glu Lys Asn Glu Ala Leu 
        595                 600                 605             

Leu Glu Lys Tyr Glu Arg Tyr Glu Tyr Leu Ser Glu Phe Asp Ser 
    610                 615                 620             

<210>   3181
<211>   1182
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3181
atgccttctg aatttcagaa ggctttacca gtattagaaa aaattaaaga agcaggcttt   60
gaggcttatt ttgttggggg ctctgttcga gatgcccttc tccatagccc tatccacgat   120
gtggatattg cgacgtcttc ttatccagaa gagaccaagc agatttttcc gcgaacagcc   180
gatatcggaa tcgagcatgg aaccgtcttg gtcttagatg gggatgagga gtatgaggta   240
acaacctttc ggacagagga tgtctatgtg gactatcgca gacccagtgc ggtttccttt   300
gtacgatcgc tagaagaaga cctcaaacgc cgtgatttca cagtcaacgc ctttgccttg   360
gatgagacag gagaaatcgt tgacttgttc catggtttag aagatttgga aaagcaagtc   420
ttgcgagcag ttggagtggc tagtgagcgt ttcaacgaag atgctttacg gattatgcgt   480
ggtttccgtt ttcaggctag tcttggtttt gcacttgagc cagaaacatt taaagctatg   540
aagaccttga cgccgctttt ggagaaaatt tctgtagagc gtaccttcgt cgagtttgat   600
aaactcttgc tggctccatt ttggagaagg ggcttggctt ccatgattga gagtcaagct   660
tatgactatc tccctgatat ggcatctagc caggacaagc tcaacagact gtttgatttg   720
gagactgatt ttacttttga atcctctgaa caagcctggg cggctttact atgggctttg   780
gagattgaaa atgcgcagtc atttttgaaa tcttggaaga cctcacgcca gtttgccaag   840
caagttcagg atttgctgat tattttggct ctgcgtgaaa atggagaatt gagcaagcga   900
gattgttatc gctttgacat agatttgctt ttacaggctg aaaatcttcg tcaagctcaa   960
ggaaaagaag tcaacccaca agccatcaca gaaaaatacc aaagcttgac tatccatgac   1020
aagaaagaga ttcagattaa tggcggtatt ttgatcaagg aatatggcta tcagccaggc   1080
ccagacttgg gagagatttt aacagagatt gagtttgcca ttgtcgatgg agaattggag   1140
aataatcgtg aagccatcca tgcttacctg agggagaaaa aa                      1182

<210>   3182
<211>   394
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   polyA polymerase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903456 (0.E+01)

<400>   3182
Met Pro Ser Glu Phe Gln Lys Ala Leu Pro Val Leu Glu Lys Ile Lys 
1               5                   10                  15      

Glu Ala Gly Phe Glu Ala Tyr Phe Val Gly Gly Ser Val Arg Asp Ala 
            20                  25                  30          

Leu Leu His Ser Pro Ile His Asp Val Asp Ile Ala Thr Ser Ser Tyr 
        35                  40                  45              

Pro Glu Glu Thr Lys Gln Ile Phe Pro Arg Thr Ala Asp Ile Gly Ile 
    50                  55                  60                  

Glu His Gly Thr Val Leu Val Leu Asp Gly Asp Glu Glu Tyr Glu Val 
65                  70                  75                  80  

Thr Thr Phe Arg Thr Glu Asp Val Tyr Val Asp Tyr Arg Arg Pro Ser 
                85                  90                  95      

Ala Val Ser Phe Val Arg Ser Leu Glu Glu Asp Leu Lys Arg Arg Asp 
            100                 105                 110         

Phe Thr Val Asn Ala Phe Ala Leu Asp Glu Thr Gly Glu Ile Val Asp 
        115                 120                 125             

Leu Phe His Gly Leu Glu Asp Leu Glu Lys Gln Val Leu Arg Ala Val 
    130                 135                 140                 

Gly Val Ala Ser Glu Arg Phe Asn Glu Asp Ala Leu Arg Ile Met Arg 
145                 150                 155                 160 

Gly Phe Arg Phe Gln Ala Ser Leu Gly Phe Ala Leu Glu Pro Glu Thr 
                165                 170                 175     

Phe Lys Ala Met Lys Thr Leu Thr Pro Leu Leu Glu Lys Ile Ser Val 
            180                 185                 190         

Glu Arg Thr Phe Val Glu Phe Asp Lys Leu Leu Leu Ala Pro Phe Trp 
        195                 200                 205             

Arg Arg Gly Leu Ala Ser Met Ile Glu Ser Gln Ala Tyr Asp Tyr Leu 
    210                 215                 220                 

Pro Asp Met Ala Ser Ser Gln Asp Lys Leu Asn Arg Leu Phe Asp Leu 
225                 230                 235                 240 

Glu Thr Asp Phe Thr Phe Glu Ser Ser Glu Gln Ala Trp Ala Ala Leu 
                245                 250                 255     

Leu Trp Ala Leu Glu Ile Glu Asn Ala Gln Ser Phe Leu Lys Ser Trp 
            260                 265                 270         

Lys Thr Ser Arg Gln Phe Ala Lys Gln Val Gln Asp Leu Leu Ile Ile 
        275                 280                 285             

Leu Ala Leu Arg Glu Asn Gly Glu Leu Ser Lys Arg Asp Cys Tyr Arg 
    290                 295                 300                 

Phe Asp Ile Asp Leu Leu Leu Gln Ala Glu Asn Leu Arg Gln Ala Gln 
305                 310                 315                 320 

Gly Lys Glu Val Asn Pro Gln Ala Ile Thr Glu Lys Tyr Gln Ser Leu 
                325                 330                 335     

Thr Ile His Asp Lys Lys Glu Ile Gln Ile Asn Gly Gly Ile Leu Ile 
            340                 345                 350         

Lys Glu Tyr Gly Tyr Gln Pro Gly Pro Asp Leu Gly Glu Ile Leu Thr 
        355                 360                 365             

Glu Ile Glu Phe Ala Ile Val Asp Gly Glu Leu Glu Asn Asn Arg Glu 
    370                 375                 380                 

Ala Ile His Ala Tyr Leu Arg Glu Lys Lys 
385                 390                 

<210>   3183
<211>   765
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3183
atgagtattc gagtaattat tgccggtttt aagggaaaga tgggccaggc tgcttgtcag   60
atggtattga ctgatccaga cttggacttg gtggcagttt tggatccttt tgagtctgag   120
tcagaatggc agggtattcc tgttttcaag gataaggctg atttagctgg ttttgaagcg   180
gatgtctggg tagattttac tactccagct gttgcctacg aaaatacacg ttttgctctt   240
gaaaatggct ttgctccagt agttggaacg actggtttca cgagtgaaga aattgcagag   300
ctaaaagaat tttctcgtgc ccaagacttg ggtggcctga ttgcccctaa ctttgccttg   360
ggtgctgtct tactcatgca atttgcgacg caggctgcca aatatttccc aaatgtggag   420
attattgagc tccatcatga caagaaaaag gatgctccga gtggaacagc cattaaaaca   480
gctgagttga tggcagaggt tcgagagtca attcagcaag gtgcagcaga tgaggaagag   540
ctgattgctg gtgctcgtgg tgctgacttt gatggtatgc gcatccactc agttcgtttg   600
ccaggcttgg tagctcatca ggaagtcatc tttggcaatc agggagaagg gttgaccctc   660
cgtcatgact cctatgatcg catctccttc atgacaggag tcaatttggg aattaaagaa   720
gttgtcaagc gtcatgagct tgtctatgga ttagaacact tatta                   765

<210>   3184
<211>   255
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydrodipicolinate reductase (dapB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903457 (e-145)

<400>   3184
Met Ser Ile Arg Val Ile Ile Ala Gly Phe Lys Gly Lys Met Gly Gln 
1               5                   10                  15      

Ala Ala Cys Gln Met Val Leu Thr Asp Pro Asp Leu Asp Leu Val Ala 
            20                  25                  30          

Val Leu Asp Pro Phe Glu Ser Glu Ser Glu Trp Gln Gly Ile Pro Val 
        35                  40                  45              

Phe Lys Asp Lys Ala Asp Leu Ala Gly Phe Glu Ala Asp Val Trp Val 
    50                  55                  60                  

Asp Phe Thr Thr Pro Ala Val Ala Tyr Glu Asn Thr Arg Phe Ala Leu 
65                  70                  75                  80  

Glu Asn Gly Phe Ala Pro Val Val Gly Thr Thr Gly Phe Thr Ser Glu 
                85                  90                  95      

Glu Ile Ala Glu Leu Lys Glu Phe Ser Arg Ala Gln Asp Leu Gly Gly 
            100                 105                 110         

Leu Ile Ala Pro Asn Phe Ala Leu Gly Ala Val Leu Leu Met Gln Phe 
        115                 120                 125             


Ala Thr Gln Ala Ala Lys Tyr Phe Pro Asn Val Glu Ile Ile Glu Leu 
    130                 135                 140                 

His His Asp Lys Lys Lys Asp Ala Pro Ser Gly Thr Ala Ile Lys Thr 
145                 150                 155                 160 

Ala Glu Leu Met Ala Glu Val Arg Glu Ser Ile Gln Gln Gly Ala Ala 
                165                 170                 175     

Asp Glu Glu Glu Leu Ile Ala Gly Ala Arg Gly Ala Asp Phe Asp Gly 
            180                 185                 190         

Met Arg Ile His Ser Val Arg Leu Pro Gly Leu Val Ala His Gln Glu 
        195                 200                 205             

Val Ile Phe Gly Asn Gln Gly Glu Gly Leu Thr Leu Arg His Asp Ser 
    210                 215                 220                 

Tyr Asp Arg Ile Ser Phe Met Thr Gly Val Asn Leu Gly Ile Lys Glu 
225                 230                 235                 240 

Val Val Lys Arg His Glu Leu Val Tyr Gly Leu Glu His Leu Leu 
                245                 250                 255 

<210>   3185
<211>   135
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3185
ttgaacacgg actacctgcc tcttgaaaaa agatgcctgt cttgcctttc gtggaaagtc   60
agtgccattc cctatttttc agaggcagct aaggtccttt gtatcttgat aattgaacac   120
gcctggaacc ctgtg                                                    135

<210>   3186
<211>   45
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   3186
Met Asn Thr Asp Tyr Leu Pro Leu Glu Lys Arg Cys Leu Ser Cys Leu 
1               5                   10                  15      

Ser Trp Lys Val Ser Ala Ile Pro Tyr Phe Ser Glu Ala Ala Lys Val 
            20                  25                  30          

Leu Cys Ile Leu Ile Ile Glu His Ala Trp Asn Pro Val 
        35                  40                  45  

<210>   3187
<211>   846
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3187
atgaaattag ctgttttcac agattcctct gcttatctca gtgcagagat cttgcaaaga   60
gaagacttgt ttgtcttgga tattcctgtc aatattgatg gtgaggaata tgtcgaaggc   120
atcaatctgt ctgctgagga attttaccaa aaaatggctc aggcttctga attgcctaag   180
accagtcaac caagtattgc caagttagat gagatcttaa cttcgctcaa agaacaaggc   240
tatacacatg ccttggggct tttcctatct tctggaattt caggttttta ccaaaatatc   300
cagtatatgg tcgatgacta tgagggctta accattgctt tcccagacac tttgattaca   360
agtgctcccc taggcatcat ggttgaaagc gtctttaatt ggcgtgatca gggcgatgat   420
tttgccagca ttcaggataa gctagccatt caaatcagcc gtacgtcagc ctttatcatg   480
gtagatgact tggatcattt ggtaaaaggt ggacgccttt caaatggggc tgccattttg   540
ggcaatttgc ttagcattaa gccaatcctt tattttaacg atcaaggtgt gattgaagtt   600
tacgaaaaag ttcgtactga aaagaaggcc accaagcgct taattgaaat tatcaaggaa   660
acaacggctt caggtcaata ccgggtcatt gtcattcatg ggaatgctcc tgaaaaggct   720
gaagaattgc gtcagcactt gcttgatttt ggcttgggtt cggatgtttc acttgctaca   780
tttggtagtg tcattggaac gcacctagga gcaggaagta ttgctctggg ttatattcca   840
gtgatt                                                              846

<210>   3188
<211>   282
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   degV family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903458 (e-156)

<400>   3188
Met Lys Leu Ala Val Phe Thr Asp Ser Ser Ala Tyr Leu Ser Ala Glu 
1               5                   10                  15      


Ile Leu Gln Arg Glu Asp Leu Phe Val Leu Asp Ile Pro Val Asn Ile 
            20                  25                  30          

Asp Gly Glu Glu Tyr Val Glu Gly Ile Asn Leu Ser Ala Glu Glu Phe 
        35                  40                  45              

Tyr Gln Lys Met Ala Gln Ala Ser Glu Leu Pro Lys Thr Ser Gln Pro 
    50                  55                  60                  

Ser Ile Ala Lys Leu Asp Glu Ile Leu Thr Ser Leu Lys Glu Gln Gly 
65                  70                  75                  80  

Tyr Thr His Ala Leu Gly Leu Phe Leu Ser Ser Gly Ile Ser Gly Phe 
                85                  90                  95      

Tyr Gln Asn Ile Gln Tyr Met Val Asp Asp Tyr Glu Gly Leu Thr Ile 
            100                 105                 110         

Ala Phe Pro Asp Thr Leu Ile Thr Ser Ala Pro Leu Gly Ile Met Val 
        115                 120                 125             

Glu Ser Val Phe Asn Trp Arg Asp Gln Gly Asp Asp Phe Ala Ser Ile 
    130                 135                 140                 

Gln Asp Lys Leu Ala Ile Gln Ile Ser Arg Thr Ser Ala Phe Ile Met 
145                 150                 155                 160 

Val Asp Asp Leu Asp His Leu Val Lys Gly Gly Arg Leu Ser Asn Gly 
                165                 170                 175     

Ala Ala Ile Leu Gly Asn Leu Leu Ser Ile Lys Pro Ile Leu Tyr Phe 
            180                 185                 190         

Asn Asp Gln Gly Val Ile Glu Val Tyr Glu Lys Val Arg Thr Glu Lys 
        195                 200                 205             

Lys Ala Thr Lys Arg Leu Ile Glu Ile Ile Lys Glu Thr Thr Ala Ser 
    210                 215                 220                 

Gly Gln Tyr Arg Val Ile Val Ile His Gly Asn Ala Pro Glu Lys Ala 
225                 230                 235                 240 

Glu Glu Leu Arg Gln His Leu Leu Asp Phe Gly Leu Gly Ser Asp Val 
                245                 250                 255     

Ser Leu Ala Thr Phe Gly Ser Val Ile Gly Thr His Leu Gly Ala Gly 
            260                 265                 270         

Ser Ile Ala Leu Gly Tyr Ile Pro Val Ile 
        275                 280         

<210>   3189
<211>   384
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3189
atggagaaag acatgaatct taaacgtgaa caagaatttg ttagtcagta tcattttgat   60
gcgcgtaatt ttgaatggga aaatgaaaat ggagctcctg aaaccaaggt ggatgtgaat   120
ttccaattgc tccaacatga ccaagaaaat caagtgactt ccttgattgt catcttgagc   180
tttatgattg tatttgataa gtttgtcatt agtggaacaa tctcacaagt aaaccatatc   240
gatggccgta ttgtcaatga accaagtgaa ttgaaccaag aagaggtgga aaccttggct   300
cgtccatgtt tgaacatgct caatcgtttg acttacgaag tgactgaaat tgcattagac   360
ttaccaggaa ttaatttgga gttc                                          384

<210>   3190
<211>   128
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903459 (2.E-70)

<400>   3190
Met Glu Lys Asp Met Asn Leu Lys Arg Glu Gln Glu Phe Val Ser Gln 
1               5                   10                  15      

Tyr His Phe Asp Ala Arg Asn Phe Glu Trp Glu Asn Glu Asn Gly Ala 
            20                  25                  30          

Pro Glu Thr Lys Val Asp Val Asn Phe Gln Leu Leu Gln His Asp Gln 
        35                  40                  45              

Glu Asn Gln Val Thr Ser Leu Ile Val Ile Leu Ser Phe Met Ile Val 
    50                  55                  60                  

Phe Asp Lys Phe Val Ile Ser Gly Thr Ile Ser Gln Val Asn His Ile 
65                  70                  75                  80  

Asp Gly Arg Ile Val Asn Glu Pro Ser Glu Leu Asn Gln Glu Glu Val 
                85                  90                  95      

Glu Thr Leu Ala Arg Pro Cys Leu Asn Met Leu Asn Arg Leu Thr Tyr 
            100                 105                 110         

Glu Val Thr Glu Ile Ala Leu Asp Leu Pro Gly Ile Asn Leu Glu Phe 
        115                 120                 125             


<210>   3191
<211>   1350
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3191
atgggtaaat attttgggac tgatggagtc cgtggagaag ctaacctaga actaacacca   60
gaattagcct ttaaactagg acgttttgga ggctatgttc ttagtcaaca tgaaacggaa   120
gcgccgaaag tctttgtagg acgtgacaca cgtatttcag gggaaatgtt ggaatcggcc   180
ttggtggcag gtctcctttc agtagggatt cacgtataca aacttggtgt ccttgcaaca   240
ccagcagtag cttacttggt tgaaactgaa ggagcaagtg ccggtgtcat gatttctgct   300
agccacaacc cagcccttga taacggaatc aagttctttg gcggtgatgg cttcaaacta   360
gatgatgaaa aagaagcaga aattgaagcc ttgctagatg ctgaggaaga cactcttcct   420
cgtccaagtg cagaaggctt aggaattttg gtagattatc cagaaggctt gcgtaagtat   480
gaaggatacc ttgtttcaac tggaactcct cttgatggaa tgaaggttgc cttggataca   540
gctaatggag cagcttctac cagtgcccgt caaatctttg cagaccttgg tgcccaattg   600
acggttatcg gggaaacacc agacggtctt aacatcaacc ttaatgttgg ttcaacacat   660
ccagaagccc ttcaagaagt ggtcaaagaa agtgggtcag ctattggttt ggcctttgat   720
ggagacagtg accgcttgat tgctgttgat gagaatggtg acatcgttga tggtgacaag   780
attatgtaca tcatcggaaa atacctttct gaaaaaggac aattggctca aaatacaatt   840
gtgacaactg ttatgtctaa ccttggtttc cacaaggcct tgaatcgcga aggtattaac   900
aaggcagtta ctgcagttgg tgaccgctac gttgttgaag aaatgagaaa atcaggctac   960
aaccttggtg gtgaacagtc tggtcacgtt atcttgatgg attacaatac cacaggtgat   1020
ggtcaattat cagcagttca attgactaaa atcatgaagg aaactggtaa gagcttatca   1080
gagttggcgg cagaagtaac gatttatcca caaaaattag ttaatatccg agtggaaaac   1140
gtcatgaagg aaaaggccat ggaagtgcca gctatcaagg ccatcatcga gaagatggaa   1200
gaagaaatgg cggggaacgg ccgtatcctt gttcgtccaa gtggaacaga acccctcttg   1260
cgtgttatgg cagaagcgcc tacaacagaa gaagtaaact actatgttga taccatcaca   1320
gatgtagttc gtgctgaaat tgggattgac                                    1350

<210>   3192
<211>   450
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoglucomutase/phosphomannomutase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903460 (0.E+01)

<400>   3192
Met Gly Lys Tyr Phe Gly Thr Asp Gly Val Arg Gly Glu Ala Asn Leu 
1               5                   10                  15      

Glu Leu Thr Pro Glu Leu Ala Phe Lys Leu Gly Arg Phe Gly Gly Tyr 
            20                  25                  30          

Val Leu Ser Gln His Glu Thr Glu Ala Pro Lys Val Phe Val Gly Arg 
        35                  40                  45              

Asp Thr Arg Ile Ser Gly Glu Met Leu Glu Ser Ala Leu Val Ala Gly 
    50                  55                  60                  

Leu Leu Ser Val Gly Ile His Val Tyr Lys Leu Gly Val Leu Ala Thr 
65                  70                  75                  80  

Pro Ala Val Ala Tyr Leu Val Glu Thr Glu Gly Ala Ser Ala Gly Val 
                85                  90                  95      

Met Ile Ser Ala Ser His Asn Pro Ala Leu Asp Asn Gly Ile Lys Phe 
            100                 105                 110         


Phe Gly Gly Asp Gly Phe Lys Leu Asp Asp Glu Lys Glu Ala Glu Ile 
        115                 120                 125             

Glu Ala Leu Leu Asp Ala Glu Glu Asp Thr Leu Pro Arg Pro Ser Ala 
    130                 135                 140                 

Glu Gly Leu Gly Ile Leu Val Asp Tyr Pro Glu Gly Leu Arg Lys Tyr 
145                 150                 155                 160 

Glu Gly Tyr Leu Val Ser Thr Gly Thr Pro Leu Asp Gly Met Lys Val 
                165                 170                 175     

Ala Leu Asp Thr Ala Asn Gly Ala Ala Ser Thr Ser Ala Arg Gln Ile 
            180                 185                 190         

Phe Ala Asp Leu Gly Ala Gln Leu Thr Val Ile Gly Glu Thr Pro Asp 
        195                 200                 205             

Gly Leu Asn Ile Asn Leu Asn Val Gly Ser Thr His Pro Glu Ala Leu 
    210                 215                 220                 

Gln Glu Val Val Lys Glu Ser Gly Ser Ala Ile Gly Leu Ala Phe Asp 
225                 230                 235                 240 

Gly Asp Ser Asp Arg Leu Ile Ala Val Asp Glu Asn Gly Asp Ile Val 
                245                 250                 255     

Asp Gly Asp Lys Ile Met Tyr Ile Ile Gly Lys Tyr Leu Ser Glu Lys 
            260                 265                 270         

Gly Gln Leu Ala Gln Asn Thr Ile Val Thr Thr Val Met Ser Asn Leu 
        275                 280                 285             

Gly Phe His Lys Ala Leu Asn Arg Glu Gly Ile Asn Lys Ala Val Thr 
    290                 295                 300                 

Ala Val Gly Asp Arg Tyr Val Val Glu Glu Met Arg Lys Ser Gly Tyr 
305                 310                 315                 320 

Asn Leu Gly Gly Glu Gln Ser Gly His Val Ile Leu Met Asp Tyr Asn 
                325                 330                 335     

Thr Thr Gly Asp Gly Gln Leu Ser Ala Val Gln Leu Thr Lys Ile Met 
            340                 345                 350         

Lys Glu Thr Gly Lys Ser Leu Ser Glu Leu Ala Ala Glu Val Thr Ile 
        355                 360                 365             

Tyr Pro Gln Lys Leu Val Asn Ile Arg Val Glu Asn Val Met Lys Glu 
    370                 375                 380                 

Lys Ala Met Glu Val Pro Ala Ile Lys Ala Ile Ile Glu Lys Met Glu 
385                 390                 395                 400 

Glu Glu Met Ala Gly Asn Gly Arg Ile Leu Val Arg Pro Ser Gly Thr 
                405                 410                 415     

Glu Pro Leu Leu Arg Val Met Ala Glu Ala Pro Thr Thr Glu Glu Val 
            420                 425                 430         

Asn Tyr Tyr Val Asp Thr Ile Thr Asp Val Val Arg Ala Glu Ile Gly 
        435                 440                 445             


Ile Asp 
    450 

<210>   3193
<211>   777
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3193
atgaaaaaaa atagtttata tatcatatcc tcactctttt ttgcttgtgt cttatttgtc   60
tatgctacgg cgacgaattt tcaaaacagt accagtgcta ggcaggtaaa aacggaaacc   120
tatactaata cagtaacaaa tgtccctatt gacatacgct ataatagtga taagtatttt   180
attagcggtt ttgcttcaga agtatcagtg gtcttgactg gtgcaaatcg cctatcgcta   240
gctagtgaaa tgcaagaaag tacacgtaaa ttcaaggtta ctgctgacct aacagatgcc   300
ggtgttggaa cgattgaagt tcctttgagc attgaagatt tacccaatgg gctgaccgct   360
gtggcgactc cgcaaaaaat tacagtcaag attggtaaga aggctcagaa ggataaggta   420
aagattgtac cagagattga ccctagtcaa attgatagtc gggtacaaat tgaaaatgtc   480
atggtgtcag ataaagaagt gtctattacg agtgaccaag agacattgga tagaattgat   540

aagattatcg ctgttttgcc aactagcgaa cgtataacag gtaattacag tggttcagta   600
cctttgcagg caatcgaccg caatggtgtt gtcttaccgg cagttatcac tccgtttgat   660
acaataatga aggtgactac aaaaccagta gcaccaagtt caagcacatc aaattcaagt   720
acaagcagtt catcggagac atcttcgtca acgaaagcaa ctagttcaaa aacgaat      777

<210>   3194
<211>   259
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903461 (e-141)

<400>   3194
Met Lys Lys Asn Ser Leu Tyr Ile Ile Ser Ser Leu Phe Phe Ala Cys 
1               5                   10                  15      

Val Leu Phe Val Tyr Ala Thr Ala Thr Asn Phe Gln Asn Ser Thr Ser 
            20                  25                  30          

Ala Arg Gln Val Lys Thr Glu Thr Tyr Thr Asn Thr Val Thr Asn Val 
        35                  40                  45              

Pro Ile Asp Ile Arg Tyr Asn Ser Asp Lys Tyr Phe Ile Ser Gly Phe 
    50                  55                  60                  

Ala Ser Glu Val Ser Val Val Leu Thr Gly Ala Asn Arg Leu Ser Leu 
65                  70                  75                  80  

Ala Ser Glu Met Gln Glu Ser Thr Arg Lys Phe Lys Val Thr Ala Asp 
                85                  90                  95      

Leu Thr Asp Ala Gly Val Gly Thr Ile Glu Val Pro Leu Ser Ile Glu 
            100                 105                 110         

Asp Leu Pro Asn Gly Leu Thr Ala Val Ala Thr Pro Gln Lys Ile Thr 
        115                 120                 125             

Val Lys Ile Gly Lys Lys Ala Gln Lys Asp Lys Val Lys Ile Val Pro 
    130                 135                 140                 

Glu Ile Asp Pro Ser Gln Ile Asp Ser Arg Val Gln Ile Glu Asn Val 
145                 150                 155                 160 

Met Val Ser Asp Lys Glu Val Ser Ile Thr Ser Asp Gln Glu Thr Leu 
                165                 170                 175     

Asp Arg Ile Asp Lys Ile Ile Ala Val Leu Pro Thr Ser Glu Arg Ile 
            180                 185                 190         

Thr Gly Asn Tyr Ser Gly Ser Val Pro Leu Gln Ala Ile Asp Arg Asn 
        195                 200                 205             

Gly Val Val Leu Pro Ala Val Ile Thr Pro Phe Asp Thr Ile Met Lys 
    210                 215                 220                 

Val Thr Thr Lys Pro Val Ala Pro Ser Ser Ser Thr Ser Asn Ser Ser 
225                 230                 235                 240 

Thr Ser Ser Ser Ser Glu Thr Ser Ser Ser Thr Lys Ala Thr Ser Ser 
                245                 250                 255     

Lys Thr Asn 
            

<210>   3195
<211>   768
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3195
ttgattgttg cttatatttt ataccatttt acaaaagcta ttgcaggaac caagattatg   60
attttggtac gtggagtttt ggtgtttatt ttagctcaaa tccttgcaaa tatgattggt   120
ttgactacga tttcttggtt aatcaatcaa attattactt atggggttat tgcggcggtt   180
gttatcttct ctccagagat tcggactggt ttggaacgtt tgggaagagc gacagatttc   240
ttttccaatg cccctattag tgctgaggaa cagatgattc gtgcctttgt taagtctgtt   300
gaatacatga gtcctcgtaa aatcggggcc ttggttgcta ttcagcgtgt acgtaccttg   360
caggagtata tttcgacagg aattcccttg gatgctaaga tttctgcaga acttctcatt   420
aacattttta ttcccaacac tcccctacat gatggtgcgg tgattatcaa agaagaacgt   480
atcgctgtga cgtctgccta tctgcccttg acaaaaaaca cagggatttc caaggaattt   540
gggaccagac accgggcggc tatcggttta tcagaagtct cagatgcctt gacttttgtc   600
gtatcagagg aaacgggagg aatttcgata acctataatg gaaggtttaa gcacaaccta   660
acacttgatg aatttgaaac agaattacgt gaaatcttac ttccaaaaga ggaagtgggt   720
cttagtttta aagaacgatt gctaggagga tggaaacatg aaaaaaaa                768

<210>   3196
<211>   256
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903462 (e-140)

<400>   3196
Met Ile Val Ala Tyr Ile Leu Tyr His Phe Thr Lys Ala Ile Ala Gly 
1               5                   10                  15      

Thr Lys Ile Met Ile Leu Val Arg Gly Val Leu Val Phe Ile Leu Ala 
            20                  25                  30          

Gln Ile Leu Ala Asn Met Ile Gly Leu Thr Thr Ile Ser Trp Leu Ile 
        35                  40                  45              

Asn Gln Ile Ile Thr Tyr Gly Val Ile Ala Ala Val Val Ile Phe Ser 
    50                  55                  60                  

Pro Glu Ile Arg Thr Gly Leu Glu Arg Leu Gly Arg Ala Thr Asp Phe 
65                  70                  75                  80  

Phe Ser Asn Ala Pro Ile Ser Ala Glu Glu Gln Met Ile Arg Ala Phe 
                85                  90                  95      

Val Lys Ser Val Glu Tyr Met Ser Pro Arg Lys Ile Gly Ala Leu Val 
            100                 105                 110         

Ala Ile Gln Arg Val Arg Thr Leu Gln Glu Tyr Ile Ser Thr Gly Ile 
        115                 120                 125             

Pro Leu Asp Ala Lys Ile Ser Ala Glu Leu Leu Ile Asn Ile Phe Ile 
    130                 135                 140                 

Pro Asn Thr Pro Leu His Asp Gly Ala Val Ile Ile Lys Glu Glu Arg 
145                 150                 155                 160 

Ile Ala Val Thr Ser Ala Tyr Leu Pro Leu Thr Lys Asn Thr Gly Ile 
                165                 170                 175     

Ser Lys Glu Phe Gly Thr Arg His Arg Ala Ala Ile Gly Leu Ser Glu 
            180                 185                 190         

Val Ser Asp Ala Leu Thr Phe Val Val Ser Glu Glu Thr Gly Gly Ile 
        195                 200                 205             

Ser Ile Thr Tyr Asn Gly Arg Phe Lys His Asn Leu Thr Leu Asp Glu 
    210                 215                 220                 

Phe Glu Thr Glu Leu Arg Glu Ile Leu Leu Pro Lys Glu Glu Val Gly 
225                 230                 235                 240 

Leu Ser Phe Lys Glu Arg Leu Leu Gly Gly Trp Lys His Glu Lys Lys 
                245                 250                 255     


<210>   3197
<211>   171
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3197
ttgttcaatg taaaatggac taggataggg aaaaaaatgc cagaaaatgg tataatagga   60
cgaaagtgtt ttgataggga ggatatcagg gatgaatttt caacaattat ccaatctgca   120
atattggacc agtttgtttg caagtccatg gacgatagct atcaatctga t            171

<210>   3198
<211>   57
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903463 (2.E-29)

<400>   3198
Met Phe Asn Val Lys Trp Thr Arg Ile Gly Lys Lys Met Pro Glu Asn 
1               5                   10                  15      

Gly Ile Ile Gly Arg Lys Cys Phe Asp Arg Glu Asp Ile Arg Asp Glu 
            20                  25                  30          

Phe Ser Thr Ile Ile Gln Ser Ala Ile Leu Asp Gln Phe Val Cys Lys 
        35                  40                  45              

Ser Met Asp Asp Ser Tyr Gln Ser Asp 
    50                  55          

<210>   3199
<211>   963
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3199
atgtctcaac tctatgatat taccattgtg ggtggtggtc ctgtcgggct ttttgcagcc   60
ttttatgccc acctacgcca agccaaggtt caaatcatcg actctcttcc ccagctaggt   120
ggacaacctg ctattctcta ccctgaaaag gaaatcctag acgtaccagg cttcccaaac   180
ctgactggag aagagttgac taaccgcttg attgaacagc taaatggatt tgatacccct   240
attcatctca atgaaacggt tcttgagatt gacaaacaag aagaatttgc catcacaact   300
tctaaaggaa gtcacctgac taaaacagtt atcatcgcta tgggtggcgg tgccttcaaa   360
ccacgtccgc tggaacttga aggggttgag ggctatgaaa atatccacta ccacgtttct   420
aacattcagc aatacgctgg taagaaagtg acgattcttg gtgggggaga ctcggctgtg   480
gattgggctt tggcttttga aaaaatcgca ccaactaccc ttgttcaccg cagagataat   540
ttccgtgcct tggaacacag tgttcaagcc ttgcaagaat catctgtaac catcaagaca   600
ccattcgccc ctagccaact ccttggaaat ggaaaaacac ttgataaact tgaaatcaca   660
aaagtcaaat ctgatgaaac tgaaaccatt gacctagacc acctctttgt caactatggt   720
ttcaaatctt ctgtcggtaa ccttaaaaac tgggggctcg acctcaaccg tcacaagatt   780
atcgtcaaca gcaaacagga atccagccaa gcaggtatct atgctatcgg tgactgctgc   840
tactatgacg gaaaaattga tctgattgcg acaggcctcg gagaagctcc aactgctgtc   900
aacaacgcta tcaactacat tgaccctgaa caaaaagtac aaccaaaaca ctctactagt   960
tta                                                                 963

<210>   3200
<211>   321
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyridine nucleotide-disulphide oxidoreductase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903464 (0.E+01)

<400>   3200
Met Ser Gln Leu Tyr Asp Ile Thr Ile Val Gly Gly Gly Pro Val Gly 
1               5                   10                  15      

Leu Phe Ala Ala Phe Tyr Ala His Leu Arg Gln Ala Lys Val Gln Ile 
            20                  25                  30          

Ile Asp Ser Leu Pro Gln Leu Gly Gly Gln Pro Ala Ile Leu Tyr Pro 
        35                  40                  45              

Glu Lys Glu Ile Leu Asp Val Pro Gly Phe Pro Asn Leu Thr Gly Glu 
    50                  55                  60                  

Glu Leu Thr Asn Arg Leu Ile Glu Gln Leu Asn Gly Phe Asp Thr Pro 
65                  70                  75                  80  

Ile His Leu Asn Glu Thr Val Leu Glu Ile Asp Lys Gln Glu Glu Phe 
                85                  90                  95      

Ala Ile Thr Thr Ser Lys Gly Ser His Leu Thr Lys Thr Val Ile Ile 
            100                 105                 110         

Ala Met Gly Gly Gly Ala Phe Lys Pro Arg Pro Leu Glu Leu Glu Gly 
        115                 120                 125             

Val Glu Gly Tyr Glu Asn Ile His Tyr His Val Ser Asn Ile Gln Gln 
    130                 135                 140                 

Tyr Ala Gly Lys Lys Val Thr Ile Leu Gly Gly Gly Asp Ser Ala Val 
145                 150                 155                 160 

Asp Trp Ala Leu Ala Phe Glu Lys Ile Ala Pro Thr Thr Leu Val His 
                165                 170                 175     

Arg Arg Asp Asn Phe Arg Ala Leu Glu His Ser Val Gln Ala Leu Gln 
            180                 185                 190         

Glu Ser Ser Val Thr Ile Lys Thr Pro Phe Ala Pro Ser Gln Leu Leu 
        195                 200                 205             

Gly Asn Gly Lys Thr Leu Asp Lys Leu Glu Ile Thr Lys Val Lys Ser 
    210                 215                 220                 

Asp Glu Thr Glu Thr Ile Asp Leu Asp His Leu Phe Val Asn Tyr Gly 
225                 230                 235                 240 

Phe Lys Ser Ser Val Gly Asn Leu Lys Asn Trp Gly Leu Asp Leu Asn 
                245                 250                 255     

Arg His Lys Ile Ile Val Asn Ser Lys Gln Glu Ser Ser Gln Ala Gly 
            260                 265                 270         

Ile Tyr Ala Ile Gly Asp Cys Cys Tyr Tyr Asp Gly Lys Ile Asp Leu 
        275                 280                 285             

Ile Ala Thr Gly Leu Gly Glu Ala Pro Thr Ala Val Asn Asn Ala Ile 
    290                 295                 300                 

Asn Tyr Ile Asp Pro Glu Gln Lys Val Gln Pro Lys His Ser Thr Ser 
305                 310                 315                 320 

Leu 
    

<210>   3201
<211>   909
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3201
atgagtttca cagtagcagt aaaagaagaa atcctgggcc aacaccatct gagctggcat   60
gaattatctg ccattatcaa aatgtctggt agcatcggtc tctcgacttc gggcttgact   120
ttgtcagttg tgacagaaaa tgccaaactg gcccgtcacc tctatgagtc ctttctccat   180
ctctatgaaa tcaaatctga aattcgtcac caccaacgga gcaatcttcg caagaatcgc   240
gtctataccg tttttacaga tgaaaaggtg caggatttgt taagtgattt gcacttggca   300
gactctttct ttggcctgga aacaggtatt gatgaggcga ttttatcgga tgaggaagca   360
ggtcgtgcct atctctgtgg cgctttcttg gcaaatggga gcattcgtga ccctgagtca   420
ggcaagtacc agttggaaat cagttctgtt tatctggacc acgcgcaagg aattgcctcc   480
cttctccaac agtttttact ggatgccaag gtgcttgagc gcaagaaggg ggctgtgacc   540
tatctccagc gagcagaaga cattatggac ttcttgatag taataggagc catgcaggca   600
cgtgatgatt ttgagcgggt taagattttg cgagaaaccc gtaacgacct caatcgggct   660
aataatgccg agacagctaa tatcgctcgg acagtttctg ccagcatgaa gaccattaac   720
aatatcagta aaatcaaaga tatcatgggc ttagaaaatt tgccagtaga tttgcaggaa   780
gtggcgcaac tgaggattca gcacccagac tactctatcc agcagttagc agatagtctc   840
agcacccctc tgaccaaaag tggtgtcaat cacagactca gaaaaatcaa taagatagcg   900
gatgaatta                                                           909

<210>   3202
<211>   303
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903465 (e-168)

<400>   3202
Met Ser Phe Thr Val Ala Val Lys Glu Glu Ile Leu Gly Gln His His 
1               5                   10                  15      

Leu Ser Trp His Glu Leu Ser Ala Ile Ile Lys Met Ser Gly Ser Ile 
            20                  25                  30          

Gly Leu Ser Thr Ser Gly Leu Thr Leu Ser Val Val Thr Glu Asn Ala 
        35                  40                  45              

Lys Leu Ala Arg His Leu Tyr Glu Ser Phe Leu His Leu Tyr Glu Ile 
    50                  55                  60                  

Lys Ser Glu Ile Arg His His Gln Arg Ser Asn Leu Arg Lys Asn Arg 
65                  70                  75                  80  

Val Tyr Thr Val Phe Thr Asp Glu Lys Val Gln Asp Leu Leu Ser Asp 
                85                  90                  95      

Leu His Leu Ala Asp Ser Phe Phe Gly Leu Glu Thr Gly Ile Asp Glu 
            100                 105                 110         

Ala Ile Leu Ser Asp Glu Glu Ala Gly Arg Ala Tyr Leu Cys Gly Ala 
        115                 120                 125             

Phe Leu Ala Asn Gly Ser Ile Arg Asp Pro Glu Ser Gly Lys Tyr Gln 
    130                 135                 140                 

Leu Glu Ile Ser Ser Val Tyr Leu Asp His Ala Gln Gly Ile Ala Ser 
145                 150                 155                 160 

Leu Leu Gln Gln Phe Leu Leu Asp Ala Lys Val Leu Glu Arg Lys Lys 
                165                 170                 175     

Gly Ala Val Thr Tyr Leu Gln Arg Ala Glu Asp Ile Met Asp Phe Leu 
            180                 185                 190         

Ile Val Ile Gly Ala Met Gln Ala Arg Asp Asp Phe Glu Arg Val Lys 
        195                 200                 205             

Ile Leu Arg Glu Thr Arg Asn Asp Leu Asn Arg Ala Asn Asn Ala Glu 
    210                 215                 220                 

Thr Ala Asn Ile Ala Arg Thr Val Ser Ala Ser Met Lys Thr Ile Asn 
225                 230                 235                 240 

Asn Ile Ser Lys Ile Lys Asp Ile Met Gly Leu Glu Asn Leu Pro Val 
                245                 250                 255     

Asp Leu Gln Glu Val Ala Gln Leu Arg Ile Gln His Pro Asp Tyr Ser 
            260                 265                 270         

Ile Gln Gln Leu Ala Asp Ser Leu Ser Thr Pro Leu Thr Lys Ser Gly 
        275                 280                 285             

Val Asn His Arg Leu Arg Lys Ile Asn Lys Ile Ala Asp Glu Leu 
    290                 295                 300             

<210>   3203
<211>   975
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3203
atgagaaaac caaagataac ggtgattggt ggagggactg gaagtcccgt cattctaaaa   60
agtctgcggg aaaaagatgt ggaaatcgca gctatcgtga cggtggcaga tgatggtggt   120
tcttcaggtg aactccgaaa aaatatgcaa cagttgacac cgccaggtga tcttcgtaat   180
gtccttgtgg ccatgtcgga tatgcctaag ttttatgaga aggtctttca gtatcggttc   240
tctgaggatg ccggagcctt tgctggccat ccattgggaa atctcatcat tgctggcttg   300
tcagaaatgc agggttcaac ctataatgcc atgcagttat tgagcaaatt tttccataca   360
acagggaaaa tttatccttc cagtgaccat cctttgaccc ttcatgcagt ctttcaggat   420
gggacagaag tggctggaga gagtcatatt gtagaccatc gaggcataat tgacaatgtc   480
tatgtgacca atgccctaaa cgatgatacg cctctggcca gccgtcgagt agtgcagacc   540
atccttgaaa gtgacatgat tgtcctaggg ccaggttccc tctttacctc tattttgccc   600
aatatcgtga ttaaggaaat tgggcgggct cttttggaaa ccaaggcaga aattgcctat   660
gtctgcaata tcatgaccca acgtggggag acggaacact ttacagatag cgaccacgtg   720
gaagtcttgc atcgtcacct tggtcgccct tttatcgaca ctgtcttggt gaatattgaa   780
aaagtgcctc aggaatacat gaattccaac cgttttgatg aatacttagt gcaagtggaa   840
cacgattttg taggtctttg taagcaagtt tcgcgcgtga tttcatctaa cttccttcgt   900
ctggaaaatg gcggtgcctt ccacgatgga gatttgattg tggacgagtt gatgcgcatt   960
atacaggtga aaaaa                                                    975

<210>   3204
<211>   325
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903466 (0.E+01)

<400>   3204
Met Arg Lys Pro Lys Ile Thr Val Ile Gly Gly Gly Thr Gly Ser Pro 
1               5                   10                  15      

Val Ile Leu Lys Ser Leu Arg Glu Lys Asp Val Glu Ile Ala Ala Ile 
            20                  25                  30          

Val Thr Val Ala Asp Asp Gly Gly Ser Ser Gly Glu Leu Arg Lys Asn 
        35                  40                  45              

Met Gln Gln Leu Thr Pro Pro Gly Asp Leu Arg Asn Val Leu Val Ala 
    50                  55                  60                  

Met Ser Asp Met Pro Lys Phe Tyr Glu Lys Val Phe Gln Tyr Arg Phe 
65                  70                  75                  80  

Ser Glu Asp Ala Gly Ala Phe Ala Gly His Pro Leu Gly Asn Leu Ile 
                85                  90                  95      

Ile Ala Gly Leu Ser Glu Met Gln Gly Ser Thr Tyr Asn Ala Met Gln 
            100                 105                 110         

Leu Leu Ser Lys Phe Phe His Thr Thr Gly Lys Ile Tyr Pro Ser Ser 
        115                 120                 125             

Asp His Pro Leu Thr Leu His Ala Val Phe Gln Asp Gly Thr Glu Val 
    130                 135                 140                 

Ala Gly Glu Ser His Ile Val Asp His Arg Gly Ile Ile Asp Asn Val 
145                 150                 155                 160 

Tyr Val Thr Asn Ala Leu Asn Asp Asp Thr Pro Leu Ala Ser Arg Arg 
                165                 170                 175     

Val Val Gln Thr Ile Leu Glu Ser Asp Met Ile Val Leu Gly Pro Gly 
            180                 185                 190         

Ser Leu Phe Thr Ser Ile Leu Pro Asn Ile Val Ile Lys Glu Ile Gly 
        195                 200                 205             

Arg Ala Leu Leu Glu Thr Lys Ala Glu Ile Ala Tyr Val Cys Asn Ile 
    210                 215                 220                 

Met Thr Gln Arg Gly Glu Thr Glu His Phe Thr Asp Ser Asp His Val 
225                 230                 235                 240 

Glu Val Leu His Arg His Leu Gly Arg Pro Phe Ile Asp Thr Val Leu 
                245                 250                 255     

Val Asn Ile Glu Lys Val Pro Gln Glu Tyr Met Asn Ser Asn Arg Phe 
            260                 265                 270         

Asp Glu Tyr Leu Val Gln Val Glu His Asp Phe Val Gly Leu Cys Lys 
        275                 280                 285             

Gln Val Ser Arg Val Ile Ser Ser Asn Phe Leu Arg Leu Glu Asn Gly 
    290                 295                 300                 

Gly Ala Phe His Asp Gly Asp Leu Ile Val Asp Glu Leu Met Arg Ile 
305                 310                 315                 320 

Ile Gln Val Lys Lys 
                325 

<210>   3205
<211>   888
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3205
atgacaaaga aacaacttca cttggtgatt gtgacaggga tgagtggcgc agggaaaact   60
gtagccattc agtccttcga ggatctaggt tatttcacca ttgataatat gccgccagct   120
ctcttgccta agtttttgca gctggttgaa attaaggaag acaatcctaa gttggccttg   180
gtagtggata tgcgtagccg ttctttcttt tcagagattc aagctgtttt ggatgagttg   240
gaaaatcaag atggtttgga tttcaaaatc ctctttttgg atgcggctga taaggaattg   300
gtcgctcgtt acaaggaaac cagacggagt cacccactag cagcagacgg tcgtatttta   360
gatggaatca agttggaacg tgaactcttg gcacctttga aaaatatgag ccaaaatgtg   420
gtggatacga ctgaactcac tccacgtgag ctgcgcaaaa cccttgcaga gcagttttca   480
gaccaagaac aagcccagtc tttccgtatc gaagtcatgt ctttcggatt taagtatgga   540
atcccgattg atgcggactt ggtctttgat gtccgtttct tgccaaatcc ctattattta   600
ccagaactga gaaaccaaac gggtgtggat gaacctgttt atgattatgt catgaaccat   660
cctgagtcag aagactttta tcaacattta ttggccttga ttgagccgat tctgccaagt   720
taccaaaagg aaggtaagtc cgttttgacc attgccatgg gatgtacggg tggacaacac   780
cgtagtgtgg catttgctaa acgcttggcg caggacttat ccaagaattg gtctgttaat   840
gaagggcatc gcgacaaaga ccgcagaaag gaaacggtaa accgttca                888

<210>   3206
<211>   296
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903467 (e-168)

<400>   3206
Met Thr Lys Lys Gln Leu His Leu Val Ile Val Thr Gly Met Ser Gly 
1               5                   10                  15      

Ala Gly Lys Thr Val Ala Ile Gln Ser Phe Glu Asp Leu Gly Tyr Phe 
            20                  25                  30          

Thr Ile Asp Asn Met Pro Pro Ala Leu Leu Pro Lys Phe Leu Gln Leu 
        35                  40                  45              

Val Glu Ile Lys Glu Asp Asn Pro Lys Leu Ala Leu Val Val Asp Met 
    50                  55                  60                  

Arg Ser Arg Ser Phe Phe Ser Glu Ile Gln Ala Val Leu Asp Glu Leu 
65                  70                  75                  80  

Glu Asn Gln Asp Gly Leu Asp Phe Lys Ile Leu Phe Leu Asp Ala Ala 
                85                  90                  95      

Asp Lys Glu Leu Val Ala Arg Tyr Lys Glu Thr Arg Arg Ser His Pro 
            100                 105                 110         

Leu Ala Ala Asp Gly Arg Ile Leu Asp Gly Ile Lys Leu Glu Arg Glu 
        115                 120                 125             

Leu Leu Ala Pro Leu Lys Asn Met Ser Gln Asn Val Val Asp Thr Thr 
    130                 135                 140                 

Glu Leu Thr Pro Arg Glu Leu Arg Lys Thr Leu Ala Glu Gln Phe Ser 
145                 150                 155                 160 

Asp Gln Glu Gln Ala Gln Ser Phe Arg Ile Glu Val Met Ser Phe Gly 
                165                 170                 175     

Phe Lys Tyr Gly Ile Pro Ile Asp Ala Asp Leu Val Phe Asp Val Arg 
            180                 185                 190         

Phe Leu Pro Asn Pro Tyr Tyr Leu Pro Glu Leu Arg Asn Gln Thr Gly 
        195                 200                 205             

Val Asp Glu Pro Val Tyr Asp Tyr Val Met Asn His Pro Glu Ser Glu 
    210                 215                 220                 

Asp Phe Tyr Gln His Leu Leu Ala Leu Ile Glu Pro Ile Leu Pro Ser 
225                 230                 235                 240 

Tyr Gln Lys Glu Gly Lys Ser Val Leu Thr Ile Ala Met Gly Cys Thr 
                245                 250                 255     

Gly Gly Gln His Arg Ser Val Ala Phe Ala Lys Arg Leu Ala Gln Asp 
            260                 265                 270         

Leu Ser Lys Asn Trp Ser Val Asn Glu Gly His Arg Asp Lys Asp Arg 
        275                 280                 285             

Arg Lys Glu Thr Val Asn Arg Ser 
    290                 295     

<210>   3207
<211>   378
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3207
atggcaaaaa caattcatac agataaggcc ccaaaggcta tcggacccta tgttcaagga   60
aaaatcgttg gcaacctttt gtttgctagc ggtcaagttc ccctatcccc tgaaactggg   120
gaaattgtag gagagaatat ccaagaacag acagagcaag tcttgaaaaa catcggtgct   180
attttggcag aagcaggaac agactttgac catgttgtca aaacaacttg cttcttgagc   240
gatatgaacg actttgttcc ttttaatgag gtttaccaaa cggccttcaa agaggaattc   300
ccagctcgtt cagctgtgga ggtagctcgt cttcctcgtg atgtaaaagt cgaaattgaa   360
gtcatcgcag agattgga                                                 378

<210>   3208
<211>   126
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   endoribonuclease L-PSP
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903468 (2.E-68)

<400>   3208
Met Ala Lys Thr Ile His Thr Asp Lys Ala Pro Lys Ala Ile Gly Pro 
1               5                   10                  15      

Tyr Val Gln Gly Lys Ile Val Gly Asn Leu Leu Phe Ala Ser Gly Gln 
            20                  25                  30          

Val Pro Leu Ser Pro Glu Thr Gly Glu Ile Val Gly Glu Asn Ile Gln 
        35                  40                  45              

Glu Gln Thr Glu Gln Val Leu Lys Asn Ile Gly Ala Ile Leu Ala Glu 
    50                  55                  60                  

Ala Gly Thr Asp Phe Asp His Val Val Lys Thr Thr Cys Phe Leu Ser 

65                  70                  75                  80  

Asp Met Asn Asp Phe Val Pro Phe Asn Glu Val Tyr Gln Thr Ala Phe 
                85                  90                  95      

Lys Glu Glu Phe Pro Ala Arg Ser Ala Val Glu Val Ala Arg Leu Pro 
            100                 105                 110         

Arg Asp Val Lys Val Glu Ile Glu Val Ile Ala Glu Ile Gly 
        115                 120                 125     

<210>   3209
<211>   591
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3209
gtgactatgg aacttaatac acacaatgct gaaatcttgc tcagtgcagc taataagtcc   60
cactatccgc aggatgaact gccagagatt gccctagcag ggcgttcaaa tgttggtaaa   120
tccagcttta tcaacactat gttgaaccgt aagaatctcg cccgtacatc aggaaaacct   180
ggtaaaaccc agctcctgaa cttttttaac attgatgaca agatgcgctt tgtggatgtg   240
cctggttatg gctatgctcg tgtttctaaa aaggaacgtg aaaagtgggg gtgcatgatt   300
gaggagtact taacgactcg ggaaaatctc cgtgcggttg tcagtctagt tgaccttcgt   360
catgacccgt cagcagatga tgtgcagatg tacgaatttc tcaagtatta tgagattcca   420
gtcatcattg tggcgaccaa ggcggacaag attcctcgtg gtaaatggaa caagcatgaa   480
tcagcaatca aaaagaaatt aaactttgac ccgagtgacg atttcatcct cttttcatct   540
gtcagtaagg cagggatgga tgaggcttgg gatgcaatct tagaaaaatt g            591

<210>   3210
<211>   197
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903469 (e-111)

<400>   3210
Met Thr Met Glu Leu Asn Thr His Asn Ala Glu Ile Leu Leu Ser Ala 
1               5                   10                  15      

Ala Asn Lys Ser His Tyr Pro Gln Asp Glu Leu Pro Glu Ile Ala Leu 
            20                  25                  30          

Ala Gly Arg Ser Asn Val Gly Lys Ser Ser Phe Ile Asn Thr Met Leu 
        35                  40                  45              

Asn Arg Lys Asn Leu Ala Arg Thr Ser Gly Lys Pro Gly Lys Thr Gln 
    50                  55                  60                  

Leu Leu Asn Phe Phe Asn Ile Asp Asp Lys Met Arg Phe Val Asp Val 
65                  70                  75                  80  

Pro Gly Tyr Gly Tyr Ala Arg Val Ser Lys Lys Glu Arg Glu Lys Trp 
                85                  90                  95      

Gly Cys Met Ile Glu Glu Tyr Leu Thr Thr Arg Glu Asn Leu Arg Ala 
            100                 105                 110         

Val Val Ser Leu Val Asp Leu Arg His Asp Pro Ser Ala Asp Asp Val 
        115                 120                 125             

Gln Met Tyr Glu Phe Leu Lys Tyr Tyr Glu Ile Pro Val Ile Ile Val 
    130                 135                 140                 

Ala Thr Lys Ala Asp Lys Ile Pro Arg Gly Lys Trp Asn Lys His Glu 
145                 150                 155                 160 

Ser Ala Ile Lys Lys Lys Leu Asn Phe Asp Pro Ser Asp Asp Phe Ile 
                165                 170                 175     

Leu Phe Ser Ser Val Ser Lys Ala Gly Met Asp Glu Ala Trp Asp Ala 
            180                 185                 190         

Ile Leu Glu Lys Leu 
        195         

<210>   3211
<211>   1230
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3211
atgtctacaa atagaaaaaa tgatatgatg gtttattgct cattttgtgg caaaaaccaa   60
gaagaagtac aaaaaataat tgctggcaac aatgctttta tttgtaatga atgcgtggag   120
ttagctcagg aaatcattcg agaagaattg gttgaggaag tcttggcaga cttgtctgag   180
gtgccaaaac caattgaact cctccatatc ttgaaccact atgtaattgg tcaagatcgt   240
gccaagcgtg ccttggcagt ggcggtttat aaccactaca aacgcatcaa tttccacgat   300
acacgcgaag agtcagaaga tgtggatttg cagaagtcaa acattttgat gattggccca   360
actggttcag ggaaaacttt ccttgcccag accttggcta agagcttgaa tgtacctttt   420
gctattgcgg atgcgacagc tctgacggag gctggttatg tgggtgagga tgtggaaaat   480
atcctcctca aactcttgca ggttgctgac tttaacatcg aacgtgcaga gcgtggcatt   540
atctatgtgg atgaaattga caagattgcc aagaagagtg agaatgtgtc tatcacacgt   600
gatgtttctg gtgaaggggt gcaacaagcc cttctcaaga ttattgaggg aactgttgct   660
agcgtaccgc ctcaaggtgg acgcaaacat ccacaacaag agatgattca agtggataca   720
aaaaatatcc tcttcatcgt gggtggtgct tttgatggta ttgaagaaat tgtcaaacaa   780

cgtctgggtg aaaaagtcat cggatttggt caaaataata aggcgattga cgaaaacagc   840
tcatacatgc aagaaatcat cgctgaagac attcaaaaat ttggtattat ccctgagttg   900
attggacgct tgcctgtttt tgcggctctt gagcaattga ccgttgatga cttggttcgc   960
atcttgaaag agccaagaaa tgccttggtg aaacaatacc aaaccttgct ttcttatgat   1020
gatgttgagt tggaatttga cgacgaagcc cttcaagaga ttgctaataa agcaatcgaa   1080
cggaagacag gggcgcgtgg acttcgctcc atcatcgaag aaaccatgct agatgtcatg   1140
tttgaggtgc cgagtcagga aaatgtgaaa ttggttcgca tcactaaaga aactgtagat   1200
ggaacggata aaccgatcct agaaacagcc                                    1230

<210>   3212
<211>   410
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent Clp protease, ATP-binding subunit ClpX (clpX)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903470 (0.E+01)

<400>   3212
Met Ser Thr Asn Arg Lys Asn Asp Met Met Val Tyr Cys Ser Phe Cys 
1               5                   10                  15      

Gly Lys Asn Gln Glu Glu Val Gln Lys Ile Ile Ala Gly Asn Asn Ala 
            20                  25                  30          

Phe Ile Cys Asn Glu Cys Val Glu Leu Ala Gln Glu Ile Ile Arg Glu 
        35                  40                  45              

Glu Leu Val Glu Glu Val Leu Ala Asp Leu Ser Glu Val Pro Lys Pro 
    50                  55                  60                  

Ile Glu Leu Leu His Ile Leu Asn His Tyr Val Ile Gly Gln Asp Arg 
65                  70                  75                  80  

Ala Lys Arg Ala Leu Ala Val Ala Val Tyr Asn His Tyr Lys Arg Ile 
                85                  90                  95      

Asn Phe His Asp Thr Arg Glu Glu Ser Glu Asp Val Asp Leu Gln Lys 
            100                 105                 110         

Ser Asn Ile Leu Met Ile Gly Pro Thr Gly Ser Gly Lys Thr Phe Leu 
        115                 120                 125             

Ala Gln Thr Leu Ala Lys Ser Leu Asn Val Pro Phe Ala Ile Ala Asp 
    130                 135                 140                 

Ala Thr Ala Leu Thr Glu Ala Gly Tyr Val Gly Glu Asp Val Glu Asn 
145                 150                 155                 160 

Ile Leu Leu Lys Leu Leu Gln Val Ala Asp Phe Asn Ile Glu Arg Ala 
                165                 170                 175     

Glu Arg Gly Ile Ile Tyr Val Asp Glu Ile Asp Lys Ile Ala Lys Lys 
            180                 185                 190         

Ser Glu Asn Val Ser Ile Thr Arg Asp Val Ser Gly Glu Gly Val Gln 
        195                 200                 205             

Gln Ala Leu Leu Lys Ile Ile Glu Gly Thr Val Ala Ser Val Pro Pro 
    210                 215                 220                 

Gln Gly Gly Arg Lys His Pro Gln Gln Glu Met Ile Gln Val Asp Thr 
225                 230                 235                 240 

Lys Asn Ile Leu Phe Ile Val Gly Gly Ala Phe Asp Gly Ile Glu Glu 
                245                 250                 255     

Ile Val Lys Gln Arg Leu Gly Glu Lys Val Ile Gly Phe Gly Gln Asn 
            260                 265                 270         

Asn Lys Ala Ile Asp Glu Asn Ser Ser Tyr Met Gln Glu Ile Ile Ala 
        275                 280                 285             

Glu Asp Ile Gln Lys Phe Gly Ile Ile Pro Glu Leu Ile Gly Arg Leu 
    290                 295                 300                 

Pro Val Phe Ala Ala Leu Glu Gln Leu Thr Val Asp Asp Leu Val Arg 
305                 310                 315                 320 

Ile Leu Lys Glu Pro Arg Asn Ala Leu Val Lys Gln Tyr Gln Thr Leu 
                325                 330                 335     

Leu Ser Tyr Asp Asp Val Glu Leu Glu Phe Asp Asp Glu Ala Leu Gln 
            340                 345                 350         

Glu Ile Ala Asn Lys Ala Ile Glu Arg Lys Thr Gly Ala Arg Gly Leu 
        355                 360                 365             

Arg Ser Ile Ile Glu Glu Thr Met Leu Asp Val Met Phe Glu Val Pro 
    370                 375                 380                 

Ser Gln Glu Asn Val Lys Leu Val Arg Ile Thr Lys Glu Thr Val Asp 
385                 390                 395                 400 

Gly Thr Asp Lys Pro Ile Leu Glu Thr Ala 
                405                 410 

<210>   3213
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3213
atggaacgga gtttatttgg tctattcacg gcttttctgt gtttcatctg ctttctggca   60
ggagcacaag cttttcgtaa aaagcgttac gggctttcta tcctcctttg gttaaatgcc   120
tttaccaatc tggtcaatag tattcatgct ttttacatga ccttattt                168

<210>   3214
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903471 (6.E-29)

<400>   3214
Met Glu Arg Ser Leu Phe Gly Leu Phe Thr Ala Phe Leu Cys Phe Ile 
1               5                   10                  15      

Cys Phe Leu Ala Gly Ala Gln Ala Phe Arg Lys Lys Arg Tyr Gly Leu 
            20                  25                  30          

Ser Ile Leu Leu Trp Leu Asn Ala Phe Thr Asn Leu Val Asn Ser Ile 
        35                  40                  45              

His Ala Phe Tyr Met Thr Leu Phe 
    50                  55      

<210>   3215
<211>   504
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3215
atgactaaga aaatcgtagc tatttgggcc caggatgaag agggtgtgat tggtaaggaa   60
aatcgtctgc cttggcattt gccagcagaa ttgcagcact ttaaagaaac aactctgaat   120
catgctatct tgatggggcg tgtgaccttt gatgggatgg ggcgtcgctt gcttccaaaa   180
cgggaaacct tgattttgac gcgtaatccg gaagaaaaga tagatggggt tgctactttt   240
caggacgtcc agtctgttct tgactggtat caggctcaag aaaagaatct ctacattatc   300
ggtgggaagc aaatttttca ggcttttgaa ccttaccttg atgaagtgat tgtcactcac   360

attcatgctc gggtggaagg agatacctat ttccctgaag aacttgactt gtctcttttt   420
gagacagttt caagcaaatt ttacgccaaa gatgagaaga atccttatga ttttaccatc   480
caataccgca agagaaagga agtc                                          504

<210>   3216
<211>   168
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydrofolate reductase (folA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903472 (1.E-95)

<400>   3216
Met Thr Lys Lys Ile Val Ala Ile Trp Ala Gln Asp Glu Glu Gly Val 
1               5                   10                  15      

Ile Gly Lys Glu Asn Arg Leu Pro Trp His Leu Pro Ala Glu Leu Gln 
            20                  25                  30          

His Phe Lys Glu Thr Thr Leu Asn His Ala Ile Leu Met Gly Arg Val 
        35                  40                  45              

Thr Phe Asp Gly Met Gly Arg Arg Leu Leu Pro Lys Arg Glu Thr Leu 
    50                  55                  60                  

Ile Leu Thr Arg Asn Pro Glu Glu Lys Ile Asp Gly Val Ala Thr Phe 
65                  70                  75                  80  

Gln Asp Val Gln Ser Val Leu Asp Trp Tyr Gln Ala Gln Glu Lys Asn 
                85                  90                  95      

Leu Tyr Ile Ile Gly Gly Lys Gln Ile Phe Gln Ala Phe Glu Pro Tyr 
            100                 105                 110         

Leu Asp Glu Val Ile Val Thr His Ile His Ala Arg Val Glu Gly Asp 
        115                 120                 125             

Thr Tyr Phe Pro Glu Glu Leu Asp Leu Ser Leu Phe Glu Thr Val Ser 
    130                 135                 140                 

Ser Lys Phe Tyr Ala Lys Asp Glu Lys Asn Pro Tyr Asp Phe Thr Ile 
145                 150                 155                 160 

Gln Tyr Arg Lys Arg Lys Glu Val 
                165             

<210>   3217
<211>   636
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3217
atgaatgtga gtgacaatca cttcatcaag gtaaggttca aaagcctgaa aaatttgctt   60
cccaccgata atgtagagat tcttttcttg agcctgatac cagtcaagaa cagactggac   120
gtcctgaaaa gtagcaaccc catctatctt ttcttccgga ttacgcgtca aaatcaaggt   180
ttcccgtttt ggaagcaagc gacgccccat cccatcaaag gtcacacgcc ccatcaagat   240
agcatgattc agagttgttt ctttaaagtg ctgcaattct gctggcaaat gccaaggcag   300
acgattttcc ttaccaatca caccctcttc atcctgggcc caaatagcta cgattttctt   360
agtcatgctt ccatcctttt cactgatagt actattttat caaaaaactc aaaaaaagac   420
tggtttggaa tagcttacaa aatagaaaaa atctgtaaga aatttcctac agatttatct   480
atgtttcctt atttcttaca aaccaggtgc ttgtccaagt tcggctgcaa gcatccaaat   540
tgttttatct gtttcagttt tagcgcctgc aaagataccg tttgtcacat cgtcaccttc   600
ttcatcagtg acatccaaac ctttttggaa aagttc                             636

<210>   3218
<211>   212
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3218
Met Asn Val Ser Asp Asn His Phe Ile Lys Val Arg Phe Lys Ser Leu 
1               5                   10                  15      

Lys Asn Leu Leu Pro Thr Asp Asn Val Glu Ile Leu Phe Leu Ser Leu 
            20                  25                  30          

Ile Pro Val Lys Asn Arg Leu Asp Val Leu Lys Ser Ser Asn Pro Ile 
        35                  40                  45              

Tyr Leu Phe Phe Arg Ile Thr Arg Gln Asn Gln Gly Phe Pro Phe Trp 
    50                  55                  60                  

Lys Gln Ala Thr Pro His Pro Ile Lys Gly His Thr Pro His Gln Asp 
65                  70                  75                  80  

Ser Met Ile Gln Ser Cys Phe Phe Lys Val Leu Gln Phe Cys Trp Gln 
                85                  90                  95      

Met Pro Arg Gln Thr Ile Phe Leu Thr Asn His Thr Leu Phe Ile Leu 
            100                 105                 110         

Gly Pro Asn Ser Tyr Asp Phe Leu Ser His Ala Ser Ile Leu Phe Thr 
        115                 120                 125             

Asp Ser Thr Ile Leu Ser Lys Asn Ser Lys Lys Asp Trp Phe Gly Ile 
    130                 135                 140                 

Ala Tyr Lys Ile Glu Lys Ile Cys Lys Lys Phe Pro Thr Asp Leu Ser 
145                 150                 155                 160 

Met Phe Pro Tyr Phe Leu Gln Thr Arg Cys Leu Ser Lys Phe Gly Cys 
                165                 170                 175     

Lys His Pro Asn Cys Phe Ile Cys Phe Ser Phe Ser Ala Cys Lys Asp 
            180                 185                 190         

Thr Val Cys His Ile Val Thr Phe Phe Ile Ser Asp Ile Gln Thr Phe 
        195                 200                 205             

Leu Glu Lys Phe 
    210         

<210>   3219
<211>   534
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3219
atgaatgagg taaagaaaat ggtagaattg aaaaaagaag cagtaaaaga cgtaacatca   60
ttgacaaaag cagcgccagt agcattggca aaaacaaagg aagtcttgaa ccaagctgtt   120
gctgatttgt atgtagctca cgttgctttg caccaagtgc actggtatat gcatggtcgt   180
ggtttccttg tatggcatcc aaaaatggat gagtacatgg aagctcttga cggtcaattg   240
gatgaaatca gtgaacgctt gattacactc ggtggaagcc cattctctac attgacagag   300
ttccttcaaa atagtgaaat cgaagaagaa gctggtgaat accgtaatgt tgaagaaagc   360
ttggaacgtg ttcttgttat ctaccgttac ttgtcagaac ttttccaaaa aggtttggat   420
gtcactgatg aagaaggtga cgatgtgaca aacggtatct ttgcaggcgc taaaactgaa   480
acagataaaa caatttggat gcttgcagcc gaacttggac aagcacctgg tttg         534

<210>   3220
<211>   178
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   non-heme iron-containing ferritin
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903473 (3.E-99)

<400>   3220
Met Asn Glu Val Lys Lys Met Val Glu Leu Lys Lys Glu Ala Val Lys 
1               5                   10                  15      

Asp Val Thr Ser Leu Thr Lys Ala Ala Pro Val Ala Leu Ala Lys Thr 
            20                  25                  30          

Lys Glu Val Leu Asn Gln Ala Val Ala Asp Leu Tyr Val Ala His Val 
        35                  40                  45              

Ala Leu His Gln Val His Trp Tyr Met His Gly Arg Gly Phe Leu Val 
    50                  55                  60                  

Trp His Pro Lys Met Asp Glu Tyr Met Glu Ala Leu Asp Gly Gln Leu 
65                  70                  75                  80  

Asp Glu Ile Ser Glu Arg Leu Ile Thr Leu Gly Gly Ser Pro Phe Ser 
                85                  90                  95      

Thr Leu Thr Glu Phe Leu Gln Asn Ser Glu Ile Glu Glu Glu Ala Gly 
            100                 105                 110         

Glu Tyr Arg Asn Val Glu Glu Ser Leu Glu Arg Val Leu Val Ile Tyr 
        115                 120                 125             

Arg Tyr Leu Ser Glu Leu Phe Gln Lys Gly Leu Asp Val Thr Asp Glu 
    130                 135                 140                 

Glu Gly Asp Asp Val Thr Asn Gly Ile Phe Ala Gly Ala Lys Thr Glu 
145                 150                 155                 160 

Thr Asp Lys Thr Ile Trp Met Leu Ala Ala Glu Leu Gly Gln Ala Pro 
                165                 170                 175     

Gly Leu 
        

<210>   3221
<211>   1518
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3221
gtggaacagc attcagatgt ctgttacatt ttttatagga gagaaagatt gaaaacaaaa   60
attggattag caagtatctg tttactaggc ttggcaacta gtcatgtcgc tgcaaatgaa   120
actgaagtag caaaaacttc gcaggataca acgacagctt caagtagttc agagcaaaat   180
cagtcttcta ataaaacgca aacgagcgca gaagtacaga ctaatgctgc tgcccactgg   240
gatggggatt attatgtaaa ggatgatggt tctaaagctc aaagtgaatg gatttttgac   300
aactactata aggcttggtt ttatattaat tcagatggtc gttactcgca gaatgaatgg   360
catggaaatt actacctgaa atcaggtgga tatatggccc aaaacgagtg gatctatgac   420
agtaattaca agagttggtt ttatctcaag tcagatgggg cttatgctca tcaagaatgg   480
caattgattg gaaataagtg gtactacttc aagaagtggg gttacatggc taaaagccaa   540
tggcaaggaa gttatttctt gaatggtcaa ggagctatga tgcaaaatga atggctctat   600
gatccagcct attctgctta tttttatcta aaatccgatg gaacttatgc taaccaagag   660
tggcaaaaag tgggcggcaa atggtactat ttcaagaagt ggggctatat ggctcggaat   720
gagtggcaag gcaactacta tttgactgga agtggtgcca tggcgactga cgaagtgatt   780
atggatggta ctcgctatat ctttgcggcc tctggtgagc tcaaagaaaa aaaagatttg   840
aatgtcggct gggttcacag agatggtaag cgctatttct ttaataatag agaagaacaa   900
gtgggaaccg aacatgctaa gaaagtcatt gatattagtg agcacaatgg tcgtatcaat   960
gattggaaaa aggttattga tgagaacgaa gtggatggtg tcattgttcg tctaggttat   1020
agcggtaaag aagacaagga attggcgcat aacattaagg agttaaaccg tctgggaatt   1080
ccttatggtg tctatctcta tacctatgct gaaaatgaga ccgatgctga gagtgacgct   1140
aaacagacca ttgaacttat aaagaaatac aatatgaacc tgtcttaccc tatctattat   1200
gatgttgaga attgggaata tgtaaataag agcaagagag ctccaagtga tacaggcact   1260
tgggttaaaa tcatcaacaa gtacatggac acgatgaagc aggcgggtta tcaaaatgtg   1320
tatgtctata gctatcgtag tttattacag acgcgtttaa aacacccaga tattttaaaa   1380
catgtaaact gggtagcggc ctatacgaat gctttagaat gggaaaaccc tcattattca   1440
ggaaaaaaag gttggcaata tacctcttct gaatacatga aaggaatcca agggcgcgta   1500
gatgtcagcg tttggtat                                                 1518

<210>   3222
<211>   506
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   lysozyme, FRAMESHIFT (lytC)
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15903474 (0.E+01)

<400>   3222
Met Glu Gln His Ser Asp Val Cys Tyr Ile Phe Tyr Arg Arg Glu Arg 
1               5                   10                  15      

Leu Lys Thr Lys Ile Gly Leu Ala Ser Ile Cys Leu Leu Gly Leu Ala 
            20                  25                  30          

Thr Ser His Val Ala Ala Asn Glu Thr Glu Val Ala Lys Thr Ser Gln 
        35                  40                  45              

Asp Thr Thr Thr Ala Ser Ser Ser Ser Glu Gln Asn Gln Ser Ser Asn 
    50                  55                  60                  

Lys Thr Gln Thr Ser Ala Glu Val Gln Thr Asn Ala Ala Ala His Trp 
65                  70                  75                  80  

Asp Gly Asp Tyr Tyr Val Lys Asp Asp Gly Ser Lys Ala Gln Ser Glu 
                85                  90                  95      

Trp Ile Phe Asp Asn Tyr Tyr Lys Ala Trp Phe Tyr Ile Asn Ser Asp 
            100                 105                 110         

Gly Arg Tyr Ser Gln Asn Glu Trp His Gly Asn Tyr Tyr Leu Lys Ser 
        115                 120                 125             

Gly Gly Tyr Met Ala Gln Asn Glu Trp Ile Tyr Asp Ser Asn Tyr Lys 
    130                 135                 140                 

Ser Trp Phe Tyr Leu Lys Ser Asp Gly Ala Tyr Ala His Gln Glu Trp 
145                 150                 155                 160 

Gln Leu Ile Gly Asn Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met 
                165                 170                 175     

Ala Lys Ser Gln Trp Gln Gly Ser Tyr Phe Leu Asn Gly Gln Gly Ala 
            180                 185                 190         

Met Met Gln Asn Glu Trp Leu Tyr Asp Pro Ala Tyr Ser Ala Tyr Phe 
        195                 200                 205             

Tyr Leu Lys Ser Asp Gly Thr Tyr Ala Asn Gln Glu Trp Gln Lys Val 
    210                 215                 220                 

Gly Gly Lys Trp Tyr Tyr Phe Lys Lys Trp Gly Tyr Met Ala Arg Asn 
225                 230                 235                 240 

Glu Trp Gln Gly Asn Tyr Tyr Leu Thr Gly Ser Gly Ala Met Ala Thr 
                245                 250                 255     

Asp Glu Val Ile Met Asp Gly Thr Arg Tyr Ile Phe Ala Ala Ser Gly 
            260                 265                 270         

Glu Leu Lys Glu Lys Lys Asp Leu Asn Val Gly Trp Val His Arg Asp 
        275                 280                 285             

Gly Lys Arg Tyr Phe Phe Asn Asn Arg Glu Glu Gln Val Gly Thr Glu 
    290                 295                 300                 

His Ala Lys Lys Val Ile Asp Ile Ser Glu His Asn Gly Arg Ile Asn 
305                 310                 315                 320 

Asp Trp Lys Lys Val Ile Asp Glu Asn Glu Val Asp Gly Val Ile Val 
                325                 330                 335     

Arg Leu Gly Tyr Ser Gly Lys Glu Asp Lys Glu Leu Ala His Asn Ile 
            340                 345                 350         

Lys Glu Leu Asn Arg Leu Gly Ile Pro Tyr Gly Val Tyr Leu Tyr Thr 
        355                 360                 365             

Tyr Ala Glu Asn Glu Thr Asp Ala Glu Ser Asp Ala Lys Gln Thr Ile 
    370                 375                 380                 

Glu Leu Ile Lys Lys Tyr Asn Met Asn Leu Ser Tyr Pro Ile Tyr Tyr 
385                 390                 395                 400 

Asp Val Glu Asn Trp Glu Tyr Val Asn Lys Ser Lys Arg Ala Pro Ser 
                405                 410                 415     

Asp Thr Gly Thr Trp Val Lys Ile Ile Asn Lys Tyr Met Asp Thr Met 
            420                 425                 430         

Lys Gln Ala Gly Tyr Gln Asn Val Tyr Val Tyr Ser Tyr Arg Ser Leu 
        435                 440                 445             

Leu Gln Thr Arg Leu Lys His Pro Asp Ile Leu Lys His Val Asn Trp 
    450                 455                 460                 

Val Ala Ala Tyr Thr Asn Ala Leu Glu Trp Glu Asn Pro His Tyr Ser 
465                 470                 475                 480 

Gly Lys Lys Gly Trp Gln Tyr Thr Ser Ser Glu Tyr Met Lys Gly Ile 
                485                 490                 495     

Gln Gly Arg Val Asp Val Ser Val Trp Tyr 
            500                 505     

<210>   3223
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3223
atgtcacgta aaccatttat cgctggtaac tggaaaatga acaaaaatcc agaagaagct   60
aaagcattcg ttgaagcagt tgcatcaaaa cttccttcat cagatcttgt tgaagcaggt   120
atcgctgctc cagctcttga tttgacaact gttcttgctg ttgcaaaagg ctcaaacctt   180
aaagttgctg ctcaaaactg ctactttgaa aatgcaggtg ctttcactgg tgaaactagc   240
ccacaagttt tgaaagaaat cggtactgac tacgttgtta tcggtcactc agaacgccgt   300
gactacttcc atgaaactga tgaagatatc aacaaaaaag caaaagcaat ctttgcgaac   360
ggtatgcttc caatcatctg ttgtggtgaa tcacttgaaa cttacgaagc tggtaaagct   420
gctgaattcg taggtgctca agtatctgct gcattggctg gattgactgc tgaacaagtt   480
gctgcctcag ttatcgctta tgagccaatc tgggctatcg gtactggtaa atcagcttca   540
caagacgatg cacaaaaaat gtgtaaagtt gttcgtgacg ttgtagctgc tgactttggt   600
caagaagtcg cagacaaagt tcgtgttcaa tacggtggtt ctgttaaacc tgaaaatgtt   660
gcttcataca tggcttgccc agacgttgac ggtgcccttg taggtggtgc gtcacttgaa   720
gctgaaagct tcttggcttt gcttgacttt gtaaaa                             756

<210>   3224
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   triosephosphate isomerase (tpi)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903475 (e-142)

<400>   3224
Met Ser Arg Lys Pro Phe Ile Ala Gly Asn Trp Lys Met Asn Lys Asn 
1               5                   10                  15      

Pro Glu Glu Ala Lys Ala Phe Val Glu Ala Val Ala Ser Lys Leu Pro 
            20                  25                  30          

Ser Ser Asp Leu Val Glu Ala Gly Ile Ala Ala Pro Ala Leu Asp Leu 
        35                  40                  45              

Thr Thr Val Leu Ala Val Ala Lys Gly Ser Asn Leu Lys Val Ala Ala 
    50                  55                  60                  

Gln Asn Cys Tyr Phe Glu Asn Ala Gly Ala Phe Thr Gly Glu Thr Ser 
65                  70                  75                  80  

Pro Gln Val Leu Lys Glu Ile Gly Thr Asp Tyr Val Val Ile Gly His 
                85                  90                  95      

Ser Glu Arg Arg Asp Tyr Phe His Glu Thr Asp Glu Asp Ile Asn Lys 
            100                 105                 110         

Lys Ala Lys Ala Ile Phe Ala Asn Gly Met Leu Pro Ile Ile Cys Cys 
        115                 120                 125             

Gly Glu Ser Leu Glu Thr Tyr Glu Ala Gly Lys Ala Ala Glu Phe Val 
    130                 135                 140                 

Gly Ala Gln Val Ser Ala Ala Leu Ala Gly Leu Thr Ala Glu Gln Val 
145                 150                 155                 160 

Ala Ala Ser Val Ile Ala Tyr Glu Pro Ile Trp Ala Ile Gly Thr Gly 
                165                 170                 175     

Lys Ser Ala Ser Gln Asp Asp Ala Gln Lys Met Cys Lys Val Val Arg 
            180                 185                 190         

Asp Val Val Ala Ala Asp Phe Gly Gln Glu Val Ala Asp Lys Val Arg 
        195                 200                 205             

Val Gln Tyr Gly Gly Ser Val Lys Pro Glu Asn Val Ala Ser Tyr Met 
    210                 215                 220                 

Ala Cys Pro Asp Val Asp Gly Ala Leu Val Gly Gly Ala Ser Leu Glu 
225                 230                 235                 240 

Ala Glu Ser Phe Leu Ala Leu Leu Asp Phe Val Lys 
                245                 250         

<210>   3225
<211>   675
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3225
atgacatatt tagacgcttt taaatcaggt accttggttt taccgagtgc cctgctcttg   60
cattttaagg aactctttcc ttctagcgac gattttctgg tttggcaatt tttctatttg   120
caaaatacga caggcttaga agaaatgtcg ccaagccaga ttgctgaaag gattggcaag   180
gaaatttcgg atgtcaacca gtccatttct aatctgacgg aaaggggact gctccagtat   240
cgtactatcg aattaaatgg cgaaattgaa ttgctctttg atgctagttt ggccttggaa   300
cgtttggatg acctgtttgg agcagttcat tcaagttcag accagctaac acctcaaaac   360
cagctcaagg atttggtgga aaccttccag caggagttgg gacgattgtt gacgcctttt   420
gagattgagg atttgaccaa gacactaaag gaagatggaa ccagtgctga cttgattaag   480
gaggctcttc gtgaagctgt tttgaatgga aaaccaaact ggaagtacat tcaggcgatt   540
ttgagaaact ggcgccatga aggaatcaag agtgtggctc aaattgaggc caagagagca   600
gaaagagaag caagcaatcc tcagttgaca caggtatctg cagatttcat aaatgccatg   660
gatctctgga aggat                                                    675

<210>   3226
<211>   225
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903476 (e-124)

<400>   3226
Met Thr Tyr Leu Asp Ala Phe Lys Ser Gly Thr Leu Val Leu Pro Ser 
1               5                   10                  15      

Ala Leu Leu Leu His Phe Lys Glu Leu Phe Pro Ser Ser Asp Asp Phe 
            20                  25                  30          

Leu Val Trp Gln Phe Phe Tyr Leu Gln Asn Thr Thr Gly Leu Glu Glu 
        35                  40                  45              

Met Ser Pro Ser Gln Ile Ala Glu Arg Ile Gly Lys Glu Ile Ser Asp 
    50                  55                  60                  

Val Asn Gln Ser Ile Ser Asn Leu Thr Glu Arg Gly Leu Leu Gln Tyr 
65                  70                  75                  80  

Arg Thr Ile Glu Leu Asn Gly Glu Ile Glu Leu Leu Phe Asp Ala Ser 
                85                  90                  95      

Leu Ala Leu Glu Arg Leu Asp Asp Leu Phe Gly Ala Val His Ser Ser 
            100                 105                 110         

Ser Asp Gln Leu Thr Pro Gln Asn Gln Leu Lys Asp Leu Val Glu Thr 
        115                 120                 125             

Phe Gln Gln Glu Leu Gly Arg Leu Leu Thr Pro Phe Glu Ile Glu Asp 
    130                 135                 140                 

Leu Thr Lys Thr Leu Lys Glu Asp Gly Thr Ser Ala Asp Leu Ile Lys 
145                 150                 155                 160 

Glu Ala Leu Arg Glu Ala Val Leu Asn Gly Lys Pro Asn Trp Lys Tyr 
                165                 170                 175     

Ile Gln Ala Ile Leu Arg Asn Trp Arg His Glu Gly Ile Lys Ser Val 
            180                 185                 190         

Ala Gln Ile Glu Ala Lys Arg Ala Glu Arg Glu Ala Ser Asn Pro Gln 
        195                 200                 205             

Leu Thr Gln Val Ser Ala Asp Phe Ile Asn Ala Met Asp Leu Trp Lys 
    210                 215                 220                 

Asp 
225 

<210>   3227
<211>   942
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3227
atgccgattc gaattgataa aaaattgcca gctgttgaga ttttacggac agagaatatc   60
tttgtcatgg atgatcaacg tgctgcccac caagatatcc gtcctttgaa gattttaatt   120
ttaaatctca tgccacagaa aatggtcaca gagacccagt tgttgcgcca cttggctaat   180
acacccctac aactggatat tgattttctc tatatggaga gccaccgttc taaaacaact   240
cgttcagagc acatggagac cttctataaa acttttcctg aagtcaagga tgagtatttt   300
gatgggatga tcatcacggg tgctccagtt gagcatttac catttgagga agtggactat   360
tgggaggaat ttagacagat gcttgagtgg tctaagactc atgtctattc gacccttcat   420
atctgttggg gggctcaggc tgggctttat ctgcgctatg gtgtagaaaa ataccagatg   480
gacagtaagc tatcaggtat ttatcctcag gacaccctaa aagagggtca ccttctattt   540
agaggctttg atgatagcta tgtatcccct cattcacggc acacggagat ttctaaggaa   600
gaggtcttaa acaagaccaa tctcgagatt ttatcagaag gacctcaggt tggggtttct   660
attttggcca gtcgtgattt acgagaaatt tatagttttg gtcatttgga gtatgaccgt   720
gataccttgg caaaagagta ttttcgagat cgtgatgcag gtttcgaccc acatattcca   780
gaaaattact ttaaagatga tgatgttaat caggtacctt gtctttgttg gtcttcatct   840
gcagccctct ttttcagtaa ttgggtagac catgcggtct atcaggagac gccttttgat   900
tggagaaaga tagaagatga tgcatctgca tatgggtatt ta                      942

<210>   3228
<211>   314
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   homoserine O-succinyltransferase (metA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903477 (0.E+01)

<400>   3228
Met Pro Ile Arg Ile Asp Lys Lys Leu Pro Ala Val Glu Ile Leu Arg 
1               5                   10                  15      

Thr Glu Asn Ile Phe Val Met Asp Asp Gln Arg Ala Ala His Gln Asp 
            20                  25                  30          

Ile Arg Pro Leu Lys Ile Leu Ile Leu Asn Leu Met Pro Gln Lys Met 
        35                  40                  45              

Val Thr Glu Thr Gln Leu Leu Arg His Leu Ala Asn Thr Pro Leu Gln 
    50                  55                  60                  

Leu Asp Ile Asp Phe Leu Tyr Met Glu Ser His Arg Ser Lys Thr Thr 
65                  70                  75                  80  

Arg Ser Glu His Met Glu Thr Phe Tyr Lys Thr Phe Pro Glu Val Lys 
                85                  90                  95      

Asp Glu Tyr Phe Asp Gly Met Ile Ile Thr Gly Ala Pro Val Glu His 
            100                 105                 110         

Leu Pro Phe Glu Glu Val Asp Tyr Trp Glu Glu Phe Arg Gln Met Leu 
        115                 120                 125             

Glu Trp Ser Lys Thr His Val Tyr Ser Thr Leu His Ile Cys Trp Gly 
    130                 135                 140                 

Ala Gln Ala Gly Leu Tyr Leu Arg Tyr Gly Val Glu Lys Tyr Gln Met 
145                 150                 155                 160 

Asp Ser Lys Leu Ser Gly Ile Tyr Pro Gln Asp Thr Leu Lys Glu Gly 
                165                 170                 175     

His Leu Leu Phe Arg Gly Phe Asp Asp Ser Tyr Val Ser Pro His Ser 
            180                 185                 190         

Arg His Thr Glu Ile Ser Lys Glu Glu Val Leu Asn Lys Thr Asn Leu 
        195                 200                 205             

Glu Ile Leu Ser Glu Gly Pro Gln Val Gly Val Ser Ile Leu Ala Ser 
    210                 215                 220                 

Arg Asp Leu Arg Glu Ile Tyr Ser Phe Gly His Leu Glu Tyr Asp Arg 
225                 230                 235                 240 


Asp Thr Leu Ala Lys Glu Tyr Phe Arg Asp Arg Asp Ala Gly Phe Asp 
                245                 250                 255     

Pro His Ile Pro Glu Asn Tyr Phe Lys Asp Asp Asp Val Asn Gln Val 
            260                 265                 270         

Pro Cys Leu Cys Trp Ser Ser Ser Ala Ala Leu Phe Phe Ser Asn Trp 
        275                 280                 285             

Val Asp His Ala Val Tyr Gln Glu Thr Pro Phe Asp Trp Arg Lys Ile 
    290                 295                 300                 

Glu Asp Asp Ala Ser Ala Tyr Gly Tyr Leu 
305                 310                 

<210>   3229
<211>   510
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3229
atgaatttaa aagattacat tgcaacaatt gaaaattatc caaaggaagg cattaccttc   60
cgtgatatta gtcctttgat ggctgatgga aatgcttata gctacgctgt tcgtgaaatc   120
gttcagtatg ctactgacaa gaaagtcgac atgatcgtgg gacctgaagc tcgtggattt   180
atcgtgggtt gtccagttgc ctttgagttg ggaattggtt ttgcgcctgt tcgtaagcca   240
ggtaaattgc cacgcgaagt tatttctgct gactatgaaa aagagtacgg tgtcgatacc   300
ttgactatgc acgcggatgc cattaagcca ggtcaacgtg ttcttattgt agatgacctt   360
ttggcgacag gtggaactgt taaggcaact atcgagatga ttgaaaaact tggtggtgtt   420
atggcaggtt gtgccttcct tgttgaattg gatgaattga acggccgtga aaaaattggt   480
gactacgact acaaagttct tatgcattat                                    510

<210>   3230
<211>   170
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   adenine phosphoribosyltransferase (apt)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903478 (3.E-96)

<400>   3230
Met Asn Leu Lys Asp Tyr Ile Ala Thr Ile Glu Asn Tyr Pro Lys Glu 
1               5                   10                  15      

Gly Ile Thr Phe Arg Asp Ile Ser Pro Leu Met Ala Asp Gly Asn Ala 
            20                  25                  30          

Tyr Ser Tyr Ala Val Arg Glu Ile Val Gln Tyr Ala Thr Asp Lys Lys 
        35                  40                  45              

Val Asp Met Ile Val Gly Pro Glu Ala Arg Gly Phe Ile Val Gly Cys 
    50                  55                  60                  

Pro Val Ala Phe Glu Leu Gly Ile Gly Phe Ala Pro Val Arg Lys Pro 
65                  70                  75                  80  

Gly Lys Leu Pro Arg Glu Val Ile Ser Ala Asp Tyr Glu Lys Glu Tyr 
                85                  90                  95      

Gly Val Asp Thr Leu Thr Met His Ala Asp Ala Ile Lys Pro Gly Gln 
            100                 105                 110         

Arg Val Leu Ile Val Asp Asp Leu Leu Ala Thr Gly Gly Thr Val Lys 
        115                 120                 125             

Ala Thr Ile Glu Met Ile Glu Lys Leu Gly Gly Val Met Ala Gly Cys 
    130                 135                 140                 

Ala Phe Leu Val Glu Leu Asp Glu Leu Asn Gly Arg Glu Lys Ile Gly 
145                 150                 155                 160 

Asp Tyr Asp Tyr Lys Val Leu Met His Tyr 
                165                 170 

<210>   3231
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3231
atgtcagaag caggtcataa gtttttagca aaattgggga aaaaacgctt acgtccaggt   60
ggaaagcgtg ccacagattg gttaattgca gaaggaggat tttcaaaaga aaagagaata   120
ctagaggttg cgtgtaatag gggaactaca gcaattgagt tggcacagcg ttttggttgc   180
aagataactg ctgttgatat ggatgctcaa gctttagaag tggctaaaaa atctgctgga   240
acggcaggtg ttgctcattt aatcagtttt gaaagagcaa atgcaatgaa acttccttat   300
caagatgcta gttttgatat tgttataaat gaagctatgc tgactatgca agccgatcaa   360
gctaagaaaa aatgtgtaat ggaatatcta agggtattaa aacctggagg tcttctcttg   420
acacatgatg tgcttcttaa ggaagctaaa gagtctatca gacaggaatt atcacaagca   480
attcatgtaa atgtaggtcc tttaactcaa gatggttggg aacaggtgat gatagaatca   540
ggttattgtg atgtgaaagc attgactggt gaaatgacat taatgaaatt atcgggtatg   600
atttatgacg aaggtttgct aggaactttg aaaatttgtg taaatgcttg taaaaaggag   660
aatagaaagc agtttttaac tatgtataaa atgtttgcta agaataaaca gaaattgggc   720
tttattgcga tggctagtta taaatcgtca aaacgt                             756

<210>   3232
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   methyltransferase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903479 (e-142)

<400>   3232
Met Ser Glu Ala Gly His Lys Phe Leu Ala Lys Leu Gly Lys Lys Arg 
1               5                   10                  15      

Leu Arg Pro Gly Gly Lys Arg Ala Thr Asp Trp Leu Ile Ala Glu Gly 
            20                  25                  30          

Gly Phe Ser Lys Glu Lys Arg Ile Leu Glu Val Ala Cys Asn Arg Gly 
        35                  40                  45              

Thr Thr Ala Ile Glu Leu Ala Gln Arg Phe Gly Cys Lys Ile Thr Ala 
    50                  55                  60                  

Val Asp Met Asp Ala Gln Ala Leu Glu Val Ala Lys Lys Ser Ala Gly 
65                  70                  75                  80  

Thr Ala Gly Val Ala His Leu Ile Ser Phe Glu Arg Ala Asn Ala Met 
                85                  90                  95      

Lys Leu Pro Tyr Gln Asp Ala Ser Phe Asp Ile Val Ile Asn Glu Ala 
            100                 105                 110         

Met Leu Thr Met Gln Ala Asp Gln Ala Lys Lys Lys Cys Val Met Glu 
        115                 120                 125             

Tyr Leu Arg Val Leu Lys Pro Gly Gly Leu Leu Leu Thr His Asp Val 
    130                 135                 140                 

Leu Leu Lys Glu Ala Lys Glu Ser Ile Arg Gln Glu Leu Ser Gln Ala 
145                 150                 155                 160 

Ile His Val Asn Val Gly Pro Leu Thr Gln Asp Gly Trp Glu Gln Val 
                165                 170                 175     

Met Ile Glu Ser Gly Tyr Cys Asp Val Lys Ala Leu Thr Gly Glu Met 
            180                 185                 190         

Thr Leu Met Lys Leu Ser Gly Met Ile Tyr Asp Glu Gly Leu Leu Gly 
        195                 200                 205             

Thr Leu Lys Ile Cys Val Asn Ala Cys Lys Lys Glu Asn Arg Lys Gln 
    210                 215                 220                 

Phe Leu Thr Met Tyr Lys Met Phe Ala Lys Asn Lys Gln Lys Leu Gly 
225                 230                 235                 240 

Phe Ile Ala Met Ala Ser Tyr Lys Ser Ser Lys Arg 
                245                 250         

<210>   3233
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3233
ttgtatgctt ttgattctag tttatcaaat aatagattag aattgtcaga taatatcatt   60
ttgtgttata atgaagaaaa aacagaggtg ttcaaatgtc agaagcaggt cataagtttt   120

<210>   3234
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3234
Met Tyr Ala Phe Asp Ser Ser Leu Ser Asn Asn Arg Leu Glu Leu Ser 
1               5                   10                  15      

Asp Asn Ile Ile Leu Cys Tyr Asn Glu Glu Lys Thr Glu Val Phe Lys 
            20                  25                  30          

Cys Gln Lys Gln Val Ile Ser Phe 
        35                  40  

<210>   3235
<211>   1128
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3235
atggtagaat tgaatcttaa aaatatttac aaaaaatatc caaacagcga acactattca   60
gttgaagatt tcaacttgaa catcaaagat aaagaattta tcgttttcgt aggaccttca   120
ggatgtggta aatcaactac actccgtatg attgctggtc ttgaagacat tacagaaggt   180
actgcatcta tcgatggcgt agttgtcaac gacgtagctc caaaagaccg tgatatcgcc   240
atggtattcc aaaactacgc tctttaccca cacatgactg tttatgacaa catggctttc   300
ggtttgaaat tgcgtaaata cagcaaagaa gacattaaca aacgtgttca agaagcagct   360
gaaatacttg gattgaaaga attcttggaa cgtaaaccag ctgacctttc aggtggtcaa   420
cgtcaacgtg ttgccatggg gcgtgcgatt gtccgtgatg cgaaagtatt cttgatggac   480
gaacctttgt caaacttgga tgccaaactt cgtgtatcaa tgcgtgctga aatcgctaaa   540
attcaccgtc gtatcggagc tacaactatc tatgtaactc acgaccaaac agaagcgatg   600
acacttgcag accgtatcgt tattatgtca gctactaaga accctgctgg tacaggtact   660
atcggacgtg tagaacaaat cggtactcct caagaagttt acaaaaatcc agttaacaaa   720
ttcgttgcag gattcatcgg aagcccagct atgaacttca tcaccgtgaa attggttggt   780
agcgaaattg tttctgacgg tttccgtttg aaagtgccag aaggagcatt gaaagttctt   840
cgtgaaaaag gctacgaagg aaaagaattg atctttggta tccgtccaga agacgtgaat   900
gcagaacctg ctttccttga aacattccca gactgtgttg taaaagcgac tatctctgta   960
tcagaactgc ttggttcaga atctcacctt tactgtcaag ttggtaaaga cgagtttgtt   1020
gcaaaagttg atgctcgtga ctacttgcaa acaggtgcaa cagttgagct tggatttgac   1080
ttgaacaaag cacacttctt cgatgtagaa actgaaaaaa caatctac                1128

<210>   3236
<211>   376
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, ATP-binding protein (msmK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903480 (0.E+01)

<400>   3236
Met Val Glu Leu Asn Leu Lys Asn Ile Tyr Lys Lys Tyr Pro Asn Ser 
1               5                   10                  15      

Glu His Tyr Ser Val Glu Asp Phe Asn Leu Asn Ile Lys Asp Lys Glu 
            20                  25                  30          

Phe Ile Val Phe Val Gly Pro Ser Gly Cys Gly Lys Ser Thr Thr Leu 
        35                  40                  45              

Arg Met Ile Ala Gly Leu Glu Asp Ile Thr Glu Gly Thr Ala Ser Ile 
    50                  55                  60                  

Asp Gly Val Val Val Asn Asp Val Ala Pro Lys Asp Arg Asp Ile Ala 
65                  70                  75                  80  

Met Val Phe Gln Asn Tyr Ala Leu Tyr Pro His Met Thr Val Tyr Asp 
                85                  90                  95      

Asn Met Ala Phe Gly Leu Lys Leu Arg Lys Tyr Ser Lys Glu Asp Ile 
            100                 105                 110         

Asn Lys Arg Val Gln Glu Ala Ala Glu Ile Leu Gly Leu Lys Glu Phe 
        115                 120                 125             

Leu Glu Arg Lys Pro Ala Asp Leu Ser Gly Gly Gln Arg Gln Arg Val 
    130                 135                 140                 

Ala Met Gly Arg Ala Ile Val Arg Asp Ala Lys Val Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Leu Ser Asn Leu Asp Ala Lys Leu Arg Val Ser Met Arg Ala 
                165                 170                 175     

Glu Ile Ala Lys Ile His Arg Arg Ile Gly Ala Thr Thr Ile Tyr Val 
            180                 185                 190         

Thr His Asp Gln Thr Glu Ala Met Thr Leu Ala Asp Arg Ile Val Ile 
        195                 200                 205             

Met Ser Ala Thr Lys Asn Pro Ala Gly Thr Gly Thr Ile Gly Arg Val 
    210                 215                 220                 

Glu Gln Ile Gly Thr Pro Gln Glu Val Tyr Lys Asn Pro Val Asn Lys 
225                 230                 235                 240 

Phe Val Ala Gly Phe Ile Gly Ser Pro Ala Met Asn Phe Ile Thr Val 
                245                 250                 255     

Lys Leu Val Gly Ser Glu Ile Val Ser Asp Gly Phe Arg Leu Lys Val 
            260                 265                 270         

Pro Glu Gly Ala Leu Lys Val Leu Arg Glu Lys Gly Tyr Glu Gly Lys 
        275                 280                 285             

Glu Leu Ile Phe Gly Ile Arg Pro Glu Asp Val Asn Ala Glu Pro Ala 
    290                 295                 300                 

Phe Leu Glu Thr Phe Pro Asp Cys Val Val Lys Ala Thr Ile Ser Val 
305                 310                 315                 320 

Ser Glu Leu Leu Gly Ser Glu Ser His Leu Tyr Cys Gln Val Gly Lys 
                325                 330                 335     

Asp Glu Phe Val Ala Lys Val Asp Ala Arg Asp Tyr Leu Gln Thr Gly 
            340                 345                 350         

Ala Thr Val Glu Leu Gly Phe Asp Leu Asn Lys Ala His Phe Phe Asp 
        355                 360                 365             

Val Glu Thr Glu Lys Thr Ile Tyr 
    370                 375     

<210>   3237
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3237
ttgcacaaaa ctttagagaa tatcggagaa tttgaagaag ataatcttta ttattcttct   60
atagacaaaa gcagaaacaa ggatcagttt tcccatattt tcgggctcta taatatttgt   120
agtggg                                                              126

<210>   3238
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3238
Met His Lys Thr Leu Glu Asn Ile Gly Glu Phe Glu Glu Asp Asn Leu 
1               5                   10                  15      

Tyr Tyr Ser Ser Ile Asp Lys Ser Arg Asn Lys Asp Gln Phe Ser His 
            20                  25                  30          

Ile Phe Gly Leu Tyr Asn Ile Cys Ser Gly 
        35                  40          

<210>   3239
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3239
atggaacaat tacattttat cacaaaactg ctcgatatta aagacccaaa catcaagatt   60
ctagatatca tcaatatgga tacccacaaa gaaattatcg ctaagctgga ttatgaggct   120
ccatcttgcc ctgattgtgg aagtctaatg aagaaatatg actttcaaaa accgtctaag   180
atcccttacc tcgaaacaac tggtatgcct tctagaattc tccttagaaa acgccgtttc   240
aagtgctatc actgttcaaa aatgatggtt gctgagactc ccctggtaaa gaaaaatcac   300
caaatccctc gtatcatcaa ccaaaaaatt gctcaaaagt taattgaaaa aatttctatg   360
actgatattg cccatcagct ggccatttca acttcaactg tcattcgcaa gctcaatgac   420
tttcactttg agcatgattt ttctcggctt ccaaagatta tgtcttggga tgagtatgcc   480
ttcactaagg gaaagatgag tttcattgcg caagattttg ataatcttaa tattatcact   540
gttcttgaag gcagaacaca agctgtcatc cgaaatcact ttcttcgcta cgatagagcc   600
gttcgttgtc aagtgaaaat cattacgatg gatatgttta gtccttacta tgacttggct   660
aaacagcttt ttccgtgtgc taaaatcgtt ctagatcgtt tccatattat ccaacatctc   720
agccgtgcca tgagtcgttt tcgtgttcaa attatgaatc agtttgaacg aaaatctcat   780
gaatacaagg ctatcaagcg ttactggaaa ctcatccaac aggatagtcg taaactcagc   840
gataaacgtt tttatcgccc tacttttcgc atgcacttaa caaataaaga aattcttgac   900
aagattttaa gctattcaga agacttgaaa caccactatc agatctatca actcttactt   960
tttcactttc agaacaaaga ccctgagaaa tttttcggac tcattgagga caatctgaag   1020
caggttcatc ctctttttca gactgtcttt aaaacctttc taaagaacaa agagaaaatc   1080
gtcaacgccc ttcaactacc ctattcaaac gccaaattgg aagcgaccaa taatctcatc   1140
aaacttatca aacgcaatgc ctttggtttt cgaaactttg aaaacttcaa aaaacggatt   1200
tttatcgctc tgaacatcaa aaaagaaagg acgaaatttg tcctttctca agct         1254

<210>   3240
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903763 (0.E+01)

<400>   3240
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Lys Ile Leu Asp Ile Ile Asn Met Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Glu Ala Pro Ser Cys Pro Asp Cys Gly Ser 
        35                  40                  45              

Leu Met Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Ser Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Pro Leu Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ala 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Glu 
    130                 135                 140                 

His Asp Phe Ser Arg Leu Pro Lys Ile Met Ser Trp Asp Glu Tyr Ala 
145                 150                 155                 160 

Phe Thr Lys Gly Lys Met Ser Phe Ile Ala Gln Asp Phe Asp Asn Leu 
                165                 170                 175     

Asn Ile Ile Thr Val Leu Glu Gly Arg Thr Gln Ala Val Ile Arg Asn 
            180                 185                 190         

His Phe Leu Arg Tyr Asp Arg Ala Val Arg Cys Gln Val Lys Ile Ile 
        195                 200                 205             

Thr Met Asp Met Phe Ser Pro Tyr Tyr Asp Leu Ala Lys Gln Leu Phe 
    210                 215                 220                 

Pro Cys Ala Lys Ile Val Leu Asp Arg Phe His Ile Ile Gln His Leu 
225                 230                 235                 240 

Ser Arg Ala Met Ser Arg Phe Arg Val Gln Ile Met Asn Gln Phe Glu 
                245                 250                 255     

Arg Lys Ser His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile 
            260                 265                 270         

Gln Gln Asp Ser Arg Lys Leu Ser Asp Lys Arg Phe Tyr Arg Pro Thr 
        275                 280                 285             

Phe Arg Met His Leu Thr Asn Lys Glu Ile Leu Asp Lys Ile Leu Ser 
    290                 295                 300                 

Tyr Ser Glu Asp Leu Lys His His Tyr Gln Ile Tyr Gln Leu Leu Leu 
305                 310                 315                 320 

Phe His Phe Gln Asn Lys Asp Pro Glu Lys Phe Phe Gly Leu Ile Glu 
                325                 330                 335     

Asp Asn Leu Lys Gln Val His Pro Leu Phe Gln Thr Val Phe Lys Thr 
            340                 345                 350         

Phe Leu Lys Asn Lys Glu Lys Ile Val Asn Ala Leu Gln Leu Pro Tyr 
        355                 360                 365             

Ser Asn Ala Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys 
    370                 375                 380                 

Arg Asn Ala Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile 
385                 390                 395                 400 

Phe Ile Ala Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser 
                405                 410                 415     

Gln Ala 
        

<210>   3241
<211>   573
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3241
atgacaaagg ctttaatttc gattgattat acagaagatt ttgttgctga tagtgggaaa   60
ctaacagcag gtgctccagc tcaggcgatt tcggatgcca tcagcaaggt aactcgatta   120
gcttttgaac gaggagatta tatcttcttt actattgatg ctcatgaaga aaacgattgt   180
ttccatccgg aaagtaagtt atttcctcct cataatctga ttgggacgag tggacggaat   240
ttatatggag atttggggat cttttatcaa gagcatggtt cagacagtcg tgtcttttgg   300
atggataaac gccattactc agctttttca gggactgacc tagatattcg tttgagagag   360
cgtagagtgt ctaccgttat cttaacaggt gtcttgacgg atatctgtgt cctacataca   420
gctatagatg cctataatct aggatatgac atcgagattg ttaaaccagc tgttgcttcc   480
atctggcctg aaaatcatca atttgcccta ggtcatttca aaaatacact cggagctaag   540
ttagtagatg aaaatctaaa tgaacttttt gag                                573

<210>   3242
<211>   191
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   isochorismatase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903481 (e-109)

<400>   3242
Met Thr Lys Ala Leu Ile Ser Ile Asp Tyr Thr Glu Asp Phe Val Ala 
1               5                   10                  15      

Asp Ser Gly Lys Leu Thr Ala Gly Ala Pro Ala Gln Ala Ile Ser Asp 
            20                  25                  30          

Ala Ile Ser Lys Val Thr Arg Leu Ala Phe Glu Arg Gly Asp Tyr Ile 
        35                  40                  45              

Phe Phe Thr Ile Asp Ala His Glu Glu Asn Asp Cys Phe His Pro Glu 
    50                  55                  60                  

Ser Lys Leu Phe Pro Pro His Asn Leu Ile Gly Thr Ser Gly Arg Asn 
65                  70                  75                  80  

Leu Tyr Gly Asp Leu Gly Ile Phe Tyr Gln Glu His Gly Ser Asp Ser 
                85                  90                  95      

Arg Val Phe Trp Met Asp Lys Arg His Tyr Ser Ala Phe Ser Gly Thr 
            100                 105                 110         

Asp Leu Asp Ile Arg Leu Arg Glu Arg Arg Val Ser Thr Val Ile Leu 
        115                 120                 125             

Thr Gly Val Leu Thr Asp Ile Cys Val Leu His Thr Ala Ile Asp Ala 
    130                 135                 140                 

Tyr Asn Leu Gly Tyr Asp Ile Glu Ile Val Lys Pro Ala Val Ala Ser 
145                 150                 155                 160 

Ile Trp Pro Glu Asn His Gln Phe Ala Leu Gly His Phe Lys Asn Thr 
                165                 170                 175     

Leu Gly Ala Lys Leu Val Asp Glu Asn Leu Asn Glu Leu Phe Glu 
            180                 185                 190     

<210>   3243
<211>   786
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3243
atggcacatt tattagaaaa aactagaaaa attacatcaa ttttgaaacg ctcagaggag   60
cagttgcagg atgagctccc ttacaacgct attacgcgtc agttagcgga tattattcat   120
tgcaatgcct gcattatcaa tagtaaggga cgtctgcttg gctattttat gcgttataaa   180
acaaatacag atcgcgtaga gcaattcttc caaactaaga ttttcccaga tgactacgtt   240
caaggggcta atatgattta cgaaacagaa gcaaacttgc ctgttgagca tgatatgagt   300
attttcccta ttgagagtag agatgatttt ccagatggct tgacgactat tgcaccgatt   360
catgtatcgg ggattcgcct tggttctttg attatttggc gtaatgataa aaaattcgaa   420
gatgaggact tggttcttgt tgagattgcc agtaccgttg ttgggattca gcttcttaac   480
ttccaacgtg aagaagatga gaaaaatatt cgtcgtcgta ctgctgtcac catggcggtc   540
aatacccttt cttactccga actccgtgct gtttcagcaa ttttagggga attaaatgga   600
aatgaaggga agttgactgc gtcagtgatt gcagatcgta tcggaatcac tcgctctgtg   660
attgtcaatg ctcttcgtaa acttgagtct gcggggatta ttgaaagtcg ctcacttgga   720
atgaagggaa cctatcttaa ggtcttgatt tcagatattt ttgaagaagt gaagaaaaga   780
gattac                                                              786

<210>   3244
<211>   262
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903482 (e-145)

<400>   3244
Met Ala His Leu Leu Glu Lys Thr Arg Lys Ile Thr Ser Ile Leu Lys 
1               5                   10                  15      

Arg Ser Glu Glu Gln Leu Gln Asp Glu Leu Pro Tyr Asn Ala Ile Thr 
            20                  25                  30          

Arg Gln Leu Ala Asp Ile Ile His Cys Asn Ala Cys Ile Ile Asn Ser 
        35                  40                  45              

Lys Gly Arg Leu Leu Gly Tyr Phe Met Arg Tyr Lys Thr Asn Thr Asp 
    50                  55                  60                  

Arg Val Glu Gln Phe Phe Gln Thr Lys Ile Phe Pro Asp Asp Tyr Val 
65                  70                  75                  80  

Gln Gly Ala Asn Met Ile Tyr Glu Thr Glu Ala Asn Leu Pro Val Glu 
                85                  90                  95      

His Asp Met Ser Ile Phe Pro Ile Glu Ser Arg Asp Asp Phe Pro Asp 
            100                 105                 110         

Gly Leu Thr Thr Ile Ala Pro Ile His Val Ser Gly Ile Arg Leu Gly 
        115                 120                 125             

Ser Leu Ile Ile Trp Arg Asn Asp Lys Lys Phe Glu Asp Glu Asp Leu 
    130                 135                 140                 

Val Leu Val Glu Ile Ala Ser Thr Val Val Gly Ile Gln Leu Leu Asn 
145                 150                 155                 160 

Phe Gln Arg Glu Glu Asp Glu Lys Asn Ile Arg Arg Arg Thr Ala Val 
                165                 170                 175     

Thr Met Ala Val Asn Thr Leu Ser Tyr Ser Glu Leu Arg Ala Val Ser 
            180                 185                 190         

Ala Ile Leu Gly Glu Leu Asn Gly Asn Glu Gly Lys Leu Thr Ala Ser 
        195                 200                 205             

Val Ile Ala Asp Arg Ile Gly Ile Thr Arg Ser Val Ile Val Asn Ala 
    210                 215                 220                 

Leu Arg Lys Leu Glu Ser Ala Gly Ile Ile Glu Ser Arg Ser Leu Gly 
225                 230                 235                 240 

Met Lys Gly Thr Tyr Leu Lys Val Leu Ile Ser Asp Ile Phe Glu Glu 
                245                 250                 255     

Val Lys Lys Arg Asp Tyr 
            260         

<210>   3245
<211>   135
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3245
ttgcctattt ttgtgtatca taatattata aaagataata taataatttt atttgtcttt   60
tcacattcgg tctccttata taaaaaagcg attcattttg aaccgctttt tcttatttat   120
cgcctttgtt acgaa                                                    135

<210>   3246
<211>   45
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3246
Met Pro Ile Phe Val Tyr His Asn Ile Ile Lys Asp Asn Ile Ile Ile 
1               5                   10                  15      

Leu Phe Val Phe Ser His Ser Val Ser Leu Tyr Lys Lys Ala Ile His 
            20                  25                  30          

Phe Glu Pro Leu Phe Leu Ile Tyr Arg Leu Cys Tyr Glu 
        35                  40                  45  

<210>   3247
<211>   1572
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3247
gtgaaattta atgaattaaa cttgtctgct gatttgctag cagaaattga aaaagctggt   60
tttgtagaag ctagtcctat ccaagaacaa actattcctt tggcccttga aggcaaggat   120
gttatcggtc aagctcagac tggtacagga aaaactgcag cctttggctt gcctaccctt   180
gaaaaaatcc gtacagaaga agcgactatc caagccttgg tcatcgctcc aactcgtgaa   240
ctagctgtcc aaagtcaaga agaactcttc cgctttggtc gtagtaaggg agtcaaagtc   300
cgttcagtat atggcggatc aagcattgaa aaacaaatta aggctcttaa atctggtgcc   360
catattgtgg tgggaactcc aggtcgcctc ttggacttga ttaaacgcaa ggccttgaaa   420
ttacaagaca ttgaaaccct tatccttgac gaagcggatg aaatgcttaa catgggcttc   480
cttgaagaca tcgaagccat tatttcccgt gtacctgaga accgtcaaac tttgcttttc   540
tcagcaacta tgccagatgc catcaaacgt atcggtgttc agtttatgaa agcccctgaa   600
catgtcaaga ttgcggctaa ggaattgaca acagaattgg ttgaccagta ctatatccgt   660
gttaaggaac aagaaaaatt tgacaccatg actcgtctca tggatgtggc acaaccagaa   720
ctcgctattg tatttggtcg taccaaacgc cgtgtggatg aattgactcg tggtttgaaa   780
attcgtggct tccgtgcaga aggaattcat ggcgacctag accaaaacaa acgtcttcgt   840
gtccttcgtg actttaaaaa tggcaatctt gatgttttgg ttgcgacaga cgttgcagcg   900
cgtggtttgg atatttcagg tgtgacccat gtctacaact acgatattcc acaagatcct   960
gagagttatg ttcaccgtat cggtcgtaca ggtcgtgctg gtaagtcagg tcaatctatt   1020
acttttgttg ctccaaacga aatgggttac cttcaaatca ttgaaaactt gactaagaaa   1080
cgcatgaaag gtctcaaacc tgcaagtgta gaagaatcct tccaatcaaa aaaacaggta   1140
gctctcaaga aaatcgaacg tgattttgca gatgaaacca ttcgtgccaa ctttgagaaa   1200
tttggtaagg atgctcgcaa attggctgct gagtttactc cagaagaatt ggcaatgtat   1260
atcttgagtc tgacagtcca agacccagat agccttccag aagtggagat tgcacgtgaa   1320
aaaccactac cgtttaaacc atcaggtaat ggtttcggtg gtaaagctaa gggaggtcgt   1380
ggaggccgtc gtggggacga ccgtcgagag cgtgatcgcc gtggcaatgg tcgccgtgat   1440
gagttcaaaa aaggaagtcg tggcaacgat cgttttgata aggaaaaacg ttaccgtaag   1500
gataataaaa aaccacgcaa tactttaagc gaaaagcaaa caggctttgt tattcgtaac   1560
aaaggcgata aa                                                       1572

<210>   3248
<211>   524
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent RNA helicase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903483 (0.E+01)

<400>   3248
Met Lys Phe Asn Glu Leu Asn Leu Ser Ala Asp Leu Leu Ala Glu Ile 
1               5                   10                  15      

Glu Lys Ala Gly Phe Val Glu Ala Ser Pro Ile Gln Glu Gln Thr Ile 
            20                  25                  30          

Pro Leu Ala Leu Glu Gly Lys Asp Val Ile Gly Gln Ala Gln Thr Gly 
        35                  40                  45              

Thr Gly Lys Thr Ala Ala Phe Gly Leu Pro Thr Leu Glu Lys Ile Arg 
    50                  55                  60                  

Thr Glu Glu Ala Thr Ile Gln Ala Leu Val Ile Ala Pro Thr Arg Glu 
65                  70                  75                  80  

Leu Ala Val Gln Ser Gln Glu Glu Leu Phe Arg Phe Gly Arg Ser Lys 
                85                  90                  95      

Gly Val Lys Val Arg Ser Val Tyr Gly Gly Ser Ser Ile Glu Lys Gln 
            100                 105                 110         

Ile Lys Ala Leu Lys Ser Gly Ala His Ile Val Val Gly Thr Pro Gly 
        115                 120                 125             

Arg Leu Leu Asp Leu Ile Lys Arg Lys Ala Leu Lys Leu Gln Asp Ile 
    130                 135                 140                 

Glu Thr Leu Ile Leu Asp Glu Ala Asp Glu Met Leu Asn Met Gly Phe 
145                 150                 155                 160 

Leu Glu Asp Ile Glu Ala Ile Ile Ser Arg Val Pro Glu Asn Arg Gln 
                165                 170                 175     

Thr Leu Leu Phe Ser Ala Thr Met Pro Asp Ala Ile Lys Arg Ile Gly 
            180                 185                 190         

Val Gln Phe Met Lys Ala Pro Glu His Val Lys Ile Ala Ala Lys Glu 
        195                 200                 205             

Leu Thr Thr Glu Leu Val Asp Gln Tyr Tyr Ile Arg Val Lys Glu Gln 
    210                 215                 220                 

Glu Lys Phe Asp Thr Met Thr Arg Leu Met Asp Val Ala Gln Pro Glu 
225                 230                 235                 240 

Leu Ala Ile Val Phe Gly Arg Thr Lys Arg Arg Val Asp Glu Leu Thr 
                245                 250                 255     

Arg Gly Leu Lys Ile Arg Gly Phe Arg Ala Glu Gly Ile His Gly Asp 
            260                 265                 270         

Leu Asp Gln Asn Lys Arg Leu Arg Val Leu Arg Asp Phe Lys Asn Gly 
        275                 280                 285             

Asn Leu Asp Val Leu Val Ala Thr Asp Val Ala Ala Arg Gly Leu Asp 
    290                 295                 300                 

Ile Ser Gly Val Thr His Val Tyr Asn Tyr Asp Ile Pro Gln Asp Pro 
305                 310                 315                 320 

Glu Ser Tyr Val His Arg Ile Gly Arg Thr Gly Arg Ala Gly Lys Ser 
                325                 330                 335     

Gly Gln Ser Ile Thr Phe Val Ala Pro Asn Glu Met Gly Tyr Leu Gln 
            340                 345                 350         

Ile Ile Glu Asn Leu Thr Lys Lys Arg Met Lys Gly Leu Lys Pro Ala 
        355                 360                 365             

Ser Val Glu Glu Ser Phe Gln Ser Lys Lys Gln Val Ala Leu Lys Lys 
    370                 375                 380                 

Ile Glu Arg Asp Phe Ala Asp Glu Thr Ile Arg Ala Asn Phe Glu Lys 
385                 390                 395                 400 

Phe Gly Lys Asp Ala Arg Lys Leu Ala Ala Glu Phe Thr Pro Glu Glu 
                405                 410                 415     

Leu Ala Met Tyr Ile Leu Ser Leu Thr Val Gln Asp Pro Asp Ser Leu 
            420                 425                 430         

Pro Glu Val Glu Ile Ala Arg Glu Lys Pro Leu Pro Phe Lys Pro Ser 
        435                 440                 445             

Gly Asn Gly Phe Gly Gly Lys Ala Lys Gly Gly Arg Gly Gly Arg Arg 
    450                 455                 460                 

Gly Asp Asp Arg Arg Glu Arg Asp Arg Arg Gly Asn Gly Arg Arg Asp 
465                 470                 475                 480 

Glu Phe Lys Lys Gly Ser Arg Gly Asn Asp Arg Phe Asp Lys Glu Lys 
                485                 490                 495     

Arg Tyr Arg Lys Asp Asn Lys Lys Pro Arg Asn Thr Leu Ser Glu Lys 
            500                 505                 510         

Gln Thr Gly Phe Val Ile Arg Asn Lys Gly Asp Lys 
        515                 520                 

<210>   3249
<211>   930
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3249
ttgttgtatc tcgcttatgg cattttaggt gggcttggtt tgggagcagg ctatattacc   60
cctgtgtcga cgattataaa atggtttcct gataaacgtg gtctcgcaac aggtttagcg   120
attatggggt ttggttttgc ttctttattg actagtccca tagcgcaaca cctcatcgca   180
ggggtagggc ttgtagaaac tttttatatt ttaggagcaa gttactttat tatcatgctc   240
ctagcttcac aattcattaa gcgtccaaat gagcaagagc ttgcaatttt atcttcttca   300
gggaaagaaa aaacagcctc tttgacgcaa ggaatggctg caaatcaggc tctaaaaagc   360
aatcggtttt atatgctttg gattattttc tttatcaaca tagcttgtgg tttaggctta   420
atttcagcgg catcgccaat ggcacaggag atggctggct tgtctacaag tcatgcagca   480
gtaatggtgg gtgttttggg gattttcaat ggatttggtc gcttgctctg ggcgagtttg   540
tctgactata tcggtcgccc tctaaccttt agtatattac tgcttgtcaa tcttttcttt   600
tctctctcac tttggctctt tacagattcc gttttatttg tagttgctat gtctattttg   660
atgacttgct atggagctgg tttttctttg attccagctt atctcagtga tatttttgga   720
accaaggaat tggccgctct gcatggttat attttaacag cttgggcaat ggctggttta   780
gcgggaccta ttttattagc agagacttat aaaatggctc attcgtacac acaaaccttg   840
ttcgtttttc tcattttata cagtatcgcc ttggctttgt cttattatct aggtcgttca   900
atcaaaaaag aaagtcaaaa agcgcttaca                                    930

<210>   3250
<211>   310
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxalate:formate antiporter

<400>   3250
Met Leu Tyr Leu Ala Tyr Gly Ile Leu Gly Gly Leu Gly Leu Gly Ala 
1               5                   10                  15      

Gly Tyr Ile Thr Pro Val Ser Thr Ile Ile Lys Trp Phe Pro Asp Lys 
            20                  25                  30          

Arg Gly Leu Ala Thr Gly Leu Ala Ile Met Gly Phe Gly Phe Ala Ser 
        35                  40                  45              

Leu Leu Thr Ser Pro Ile Ala Gln His Leu Ile Ala Gly Val Gly Leu 
    50                  55                  60                  

Val Glu Thr Phe Tyr Ile Leu Gly Ala Ser Tyr Phe Ile Ile Met Leu 
65                  70                  75                  80  

Leu Ala Ser Gln Phe Ile Lys Arg Pro Asn Glu Gln Glu Leu Ala Ile 
                85                  90                  95      

Leu Ser Ser Ser Gly Lys Glu Lys Thr Ala Ser Leu Thr Gln Gly Met 
            100                 105                 110         

Ala Ala Asn Gln Ala Leu Lys Ser Asn Arg Phe Tyr Met Leu Trp Ile 
        115                 120                 125             

Ile Phe Phe Ile Asn Ile Ala Cys Gly Leu Gly Leu Ile Ser Ala Ala 
    130                 135                 140                 

Ser Pro Met Ala Gln Glu Met Ala Gly Leu Ser Thr Ser His Ala Ala 
145                 150                 155                 160 

Val Met Val Gly Val Leu Gly Ile Phe Asn Gly Phe Gly Arg Leu Leu 
                165                 170                 175     

Trp Ala Ser Leu Ser Asp Tyr Ile Gly Arg Pro Leu Thr Phe Ser Ile 
            180                 185                 190         

Leu Leu Leu Val Asn Leu Phe Phe Ser Leu Ser Leu Trp Leu Phe Thr 
        195                 200                 205             

Asp Ser Val Leu Phe Val Val Ala Met Ser Ile Leu Met Thr Cys Tyr 
    210                 215                 220                 

Gly Ala Gly Phe Ser Leu Ile Pro Ala Tyr Leu Ser Asp Ile Phe Gly 
225                 230                 235                 240 

Thr Lys Glu Leu Ala Ala Leu His Gly Tyr Ile Leu Thr Ala Trp Ala 
                245                 250                 255     

Met Ala Gly Leu Ala Gly Pro Ile Leu Leu Ala Glu Thr Tyr Lys Met 
            260                 265                 270         

Ala His Ser Tyr Thr Gln Thr Leu Phe Val Phe Leu Ile Leu Tyr Ser 
        275                 280                 285             

Ile Ala Leu Ala Leu Ser Tyr Tyr Leu Gly Arg Ser Ile Lys Lys Glu 
    290                 295                 300                 

Ser Gln Lys Ala Leu Thr 
305                 310 

<210>   3251
<211>   318
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3251
atgaaatcga atcgttatat tattgccttt gctggggtca ttttacactt aatgctgggt   60
tcgacttatg cttggagtgt ttatcgtaac cctattattg aaaaaacggg atgggatcag   120
gcttctgttg ccttcgcctt tagtctagca atcttttgtt tgggcttatc ggctgcattt   180
atggggcgtt tggtagaaaa atttggtccg aaagtcatgg gaagtctatc tgcttttcta   240
tacgcaggtg gaaatatctt aacaggattt gcaatagacc gtcagagctg tggttgttgt   300
atctcgctta tggcattt                                                 318

<210>   3252
<211>   106
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxalate:formate antiporter FRAMESHIFT
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903484 (0.E+01)

<400>   3252
Met Lys Ser Asn Arg Tyr Ile Ile Ala Phe Ala Gly Val Ile Leu His 
1               5                   10                  15      

Leu Met Leu Gly Ser Thr Tyr Ala Trp Ser Val Tyr Arg Asn Pro Ile 
            20                  25                  30          

Ile Glu Lys Thr Gly Trp Asp Gln Ala Ser Val Ala Phe Ala Phe Ser 
        35                  40                  45              

Leu Ala Ile Phe Cys Leu Gly Leu Ser Ala Ala Phe Met Gly Arg Leu 
    50                  55                  60                  

Val Glu Lys Phe Gly Pro Lys Val Met Gly Ser Leu Ser Ala Phe Leu 
65                  70                  75                  80  

Tyr Ala Gly Gly Asn Ile Leu Thr Gly Phe Ala Ile Asp Arg Gln Ser 
                85                  90                  95      

Cys Gly Cys Cys Ile Ser Leu Met Ala Phe 
            100                 105     

<210>   3253
<211>   1314
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3253
atgttaacat acgatttaat tgttattgga tttggtaaag ctggtaaaac actagcaggt   60
aaattggctt cagctggcaa aaaagttgcc ctcgttgaac gcagcaaggc tatgtacggt   120
ggaacttgta tcaacattgg ttgtatccca actaaaacct tgctagttgc tgctgaaaag   180
gacttgtctt ttgaagaagt cattgctact aaaaacacga tcactggtcg cctcaacggt   240
aaaaactatg cgactgttgc tggtacaggc gtagatatct ttgatgcgga agctcacttc   300
ctttcaaata aagtcatcga aatccaagct ggtgatgaaa agaaagaact gactgctgaa   360
acaatcgtca tcaacactgg tgctgtttca aacgtcttgc caatccctgg acttgctaca   420
agcaaaaaca tctttgactc aacaggtatc caaagcttgg acaaattacc tgaaaaactt   480
ggaatccttg gtggcggaaa tatcggtctt gaatttgccg gcctttacaa caaacttgga   540
agcaaggtca cagtcctaga tgccttggat acattcctac ctcgtgcaga accttccatc   600
gcagctcttg ctaaacaata catggaagaa gatggcattg aattgcttca aaatatccat   660
actactgaaa tcaaaaacga tggtgaccaa gtgcttgtcg taactgaaga cgaaacttac   720
cgtttcgacg cccttctcta cgcaactgga cgcaaaccaa atgtagaacc acttcaactt   780
gaaaatacag atattgaact aactgaacgt ggtgctatta aagtagacaa acactgtcaa   840
acaaacgttc ctggtgtctt tgcagttgga gatgtcaacg gtggccttca atttacttac   900
atttcacttg atgacttccg tgttgtttac agctaccttg ctggagatgg cagctataca   960
cttgaagacc gtctcaatgt gccaaatact atgttcatca cacctgcact ttcacaagtt   1020
ggtttgactg aaagccaagc agctgatttg aaacttccat acgctgttaa ggaaatcccc   1080
gttgcagcaa tgcctcgtgg tcacgtaaat ggagaccttc gcggtgcctt caaagctgtt   1140
gtcaatactg aaacaaaaga aattcttgga gcaagcatct tctcagaagg ttctcaagaa   1200
atcatcaaca tcatcactgt tgctatggac aacaagattc cttacactta cttcacaaaa   1260
caaatcttca ctcacccaac cttggctgag aacttgaatg acttgtttgc gatt         1314

<210>   3254
<211>   438
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, pyridine nucleotide-disulfide, class I
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903485 (0.E+01)

<400>   3254
Met Leu Thr Tyr Asp Leu Ile Val Ile Gly Phe Gly Lys Ala Gly Lys 
1               5                   10                  15      

Thr Leu Ala Gly Lys Leu Ala Ser Ala Gly Lys Lys Val Ala Leu Val 
            20                  25                  30          

Glu Arg Ser Lys Ala Met Tyr Gly Gly Thr Cys Ile Asn Ile Gly Cys 
        35                  40                  45              

Ile Pro Thr Lys Thr Leu Leu Val Ala Ala Glu Lys Asp Leu Ser Phe 
    50                  55                  60                  

Glu Glu Val Ile Ala Thr Lys Asn Thr Ile Thr Gly Arg Leu Asn Gly 
65                  70                  75                  80  

Lys Asn Tyr Ala Thr Val Ala Gly Thr Gly Val Asp Ile Phe Asp Ala 
                85                  90                  95      

Glu Ala His Phe Leu Ser Asn Lys Val Ile Glu Ile Gln Ala Gly Asp 
            100                 105                 110         

Glu Lys Lys Glu Leu Thr Ala Glu Thr Ile Val Ile Asn Thr Gly Ala 
        115                 120                 125             

Val Ser Asn Val Leu Pro Ile Pro Gly Leu Ala Thr Ser Lys Asn Ile 
    130                 135                 140                 

Phe Asp Ser Thr Gly Ile Gln Ser Leu Asp Lys Leu Pro Glu Lys Leu 
145                 150                 155                 160 

Gly Ile Leu Gly Gly Gly Asn Ile Gly Leu Glu Phe Ala Gly Leu Tyr 
                165                 170                 175     

Asn Lys Leu Gly Ser Lys Val Thr Val Leu Asp Ala Leu Asp Thr Phe 
            180                 185                 190         

Leu Pro Arg Ala Glu Pro Ser Ile Ala Ala Leu Ala Lys Gln Tyr Met 
        195                 200                 205             

Glu Glu Asp Gly Ile Glu Leu Leu Gln Asn Ile His Thr Thr Glu Ile 
    210                 215                 220                 

Lys Asn Asp Gly Asp Gln Val Leu Val Val Thr Glu Asp Glu Thr Tyr 
225                 230                 235                 240 

Arg Phe Asp Ala Leu Leu Tyr Ala Thr Gly Arg Lys Pro Asn Val Glu 
                245                 250                 255     

Pro Leu Gln Leu Glu Asn Thr Asp Ile Glu Leu Thr Glu Arg Gly Ala 
            260                 265                 270         

Ile Lys Val Asp Lys His Cys Gln Thr Asn Val Pro Gly Val Phe Ala 
        275                 280                 285             

Val Gly Asp Val Asn Gly Gly Leu Gln Phe Thr Tyr Ile Ser Leu Asp 
    290                 295                 300                 

Asp Phe Arg Val Val Tyr Ser Tyr Leu Ala Gly Asp Gly Ser Tyr Thr 
305                 310                 315                 320 

Leu Glu Asp Arg Leu Asn Val Pro Asn Thr Met Phe Ile Thr Pro Ala 
                325                 330                 335     

Leu Ser Gln Val Gly Leu Thr Glu Ser Gln Ala Ala Asp Leu Lys Leu 
            340                 345                 350         

Pro Tyr Ala Val Lys Glu Ile Pro Val Ala Ala Met Pro Arg Gly His 
        355                 360                 365             

Val Asn Gly Asp Leu Arg Gly Ala Phe Lys Ala Val Val Asn Thr Glu 
    370                 375                 380                 

Thr Lys Glu Ile Leu Gly Ala Ser Ile Phe Ser Glu Gly Ser Gln Glu 
385                 390                 395                 400 

Ile Ile Asn Ile Ile Thr Val Ala Met Asp Asn Lys Ile Pro Tyr Thr 
                405                 410                 415     

Tyr Phe Thr Lys Gln Ile Phe Thr His Pro Thr Leu Ala Glu Asn Leu 
            420                 425                 430         

Asn Asp Leu Phe Ala Ile 
        435             

<210>   3255
<211>   1341
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3255
atgaacttaa aaactacttt gggccttctt gctgggcgtt cttcccactt cgttttaagc   60
cgtcttggac gtggaagtac gctcccaggg aaagtcgccc ttcaatttga taaagatatt   120
ttacaaaacc tagctaagaa ctacgagatt gtcgttgtca ctggaacaaa tggaaaaacc   180
ctgacaactg ccctcactgt cggcatttta aaagaggttt atggtcaagt tctaaccaac   240
ccaagcggtg ccaacatgat tacagggatt gcaacaacct tcctaacagc caaatcttct   300
aaaactggga aaaatattgc cgtcctcgaa attgacgaag ccagtctatc tcgtatctgt   360
gactatatcc agcctagtct ttttgtcatt actaatatct tccgtgacca gatggaccgt   420
ttcggtgaaa tctatactac ctataacatg atattggatg ccattcggaa agttccaact   480
gctactgttc tccttaacgg agacagtcca cttttctaca agccaactat tccaaaccct   540
atagagtatt ttggttttga cttggaaaag ggaccagccc aactggctca ctacaatacc   600
gaagggattc tctgtcctga ctgccaaggc atcctcaaat atgagcataa tacctatgca   660
aacttgggtg cctatatctg tgaaggttgt ggatgtaaac gtcctgatct cgactatcgt   720
ttgacaaaac tggttgagtt gaccaacaat cgctctcgct ttgtcataga cggccaagaa   780
tacggtatcc aaatcggcgg gctctataat atctataacg ccctagctgc tgtggccatc   840
gcccgtttcc taggtgccga ttcgcaactc atcaaacagg gatttgacaa gagccgtgct   900
gtctttggac gccaagaaac ctttcatatc ggtgacaagg aatgtaccct tgtcttgatt   960
aaaaatccag tcggtgcaac ccaagctatc gaaatgatca aactagcacc ttatccattt   1020
agcctatctg tcctccttaa tgccaactat gcagatggaa ttgacactag ctggatctgg   1080
gatgcagact ttgaacaaat cactgacatg gacattcctg aaatcaacgc tggcggtgtt   1140
cgtcattctg aaatcgctcg tcgcctccga gtgactggct atccagctga gaaaatcact   1200
gaaacgagta atctggagca agttctcaag accattgaga atcaagactg caagcatgcc   1260
tatattctgg caacttatac tgccatgctg gaatttcgtg aactgctggc tagtcgtcag   1320
attgttagaa aggagatgaa c                                             1341

<210>   3256
<211>   447
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Mur ligase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903486 (0.E+01)

<400>   3256
Met Asn Leu Lys Thr Thr Leu Gly Leu Leu Ala Gly Arg Ser Ser His 
1               5                   10                  15      

Phe Val Leu Ser Arg Leu Gly Arg Gly Ser Thr Leu Pro Gly Lys Val 
            20                  25                  30          

Ala Leu Gln Phe Asp Lys Asp Ile Leu Gln Asn Leu Ala Lys Asn Tyr 
        35                  40                  45              

Glu Ile Val Val Val Thr Gly Thr Asn Gly Lys Thr Leu Thr Thr Ala 
    50                  55                  60                  

Leu Thr Val Gly Ile Leu Lys Glu Val Tyr Gly Gln Val Leu Thr Asn 
65                  70                  75                  80  

Pro Ser Gly Ala Asn Met Ile Thr Gly Ile Ala Thr Thr Phe Leu Thr 
                85                  90                  95      

Ala Lys Ser Ser Lys Thr Gly Lys Asn Ile Ala Val Leu Glu Ile Asp 
            100                 105                 110         

Glu Ala Ser Leu Ser Arg Ile Cys Asp Tyr Ile Gln Pro Ser Leu Phe 
        115                 120                 125             

Val Ile Thr Asn Ile Phe Arg Asp Gln Met Asp Arg Phe Gly Glu Ile 
    130                 135                 140                 

Tyr Thr Thr Tyr Asn Met Ile Leu Asp Ala Ile Arg Lys Val Pro Thr 
145                 150                 155                 160 

Ala Thr Val Leu Leu Asn Gly Asp Ser Pro Leu Phe Tyr Lys Pro Thr 
                165                 170                 175     

Ile Pro Asn Pro Ile Glu Tyr Phe Gly Phe Asp Leu Glu Lys Gly Pro 
            180                 185                 190         

Ala Gln Leu Ala His Tyr Asn Thr Glu Gly Ile Leu Cys Pro Asp Cys 
        195                 200                 205             

Gln Gly Ile Leu Lys Tyr Glu His Asn Thr Tyr Ala Asn Leu Gly Ala 
    210                 215                 220                 

Tyr Ile Cys Glu Gly Cys Gly Cys Lys Arg Pro Asp Leu Asp Tyr Arg 
225                 230                 235                 240 

Leu Thr Lys Leu Val Glu Leu Thr Asn Asn Arg Ser Arg Phe Val Ile 
                245                 250                 255     

Asp Gly Gln Glu Tyr Gly Ile Gln Ile Gly Gly Leu Tyr Asn Ile Tyr 
            260                 265                 270         

Asn Ala Leu Ala Ala Val Ala Ile Ala Arg Phe Leu Gly Ala Asp Ser 
        275                 280                 285             

Gln Leu Ile Lys Gln Gly Phe Asp Lys Ser Arg Ala Val Phe Gly Arg 
    290                 295                 300                 

Gln Glu Thr Phe His Ile Gly Asp Lys Glu Cys Thr Leu Val Leu Ile 
305                 310                 315                 320 

Lys Asn Pro Val Gly Ala Thr Gln Ala Ile Glu Met Ile Lys Leu Ala 
                325                 330                 335     

Pro Tyr Pro Phe Ser Leu Ser Val Leu Leu Asn Ala Asn Tyr Ala Asp 
            340                 345                 350         

Gly Ile Asp Thr Ser Trp Ile Trp Asp Ala Asp Phe Glu Gln Ile Thr 
        355                 360                 365             

Asp Met Asp Ile Pro Glu Ile Asn Ala Gly Gly Val Arg His Ser Glu 
    370                 375                 380                 

Ile Ala Arg Arg Leu Arg Val Thr Gly Tyr Pro Ala Glu Lys Ile Thr 
385                 390                 395                 400 

Glu Thr Ser Asn Leu Glu Gln Val Leu Lys Thr Ile Glu Asn Gln Asp 
                405                 410                 415     

Cys Lys His Ala Tyr Ile Leu Ala Thr Tyr Thr Ala Met Leu Glu Phe 
            420                 425                 430         

Arg Glu Leu Leu Ala Ser Arg Gln Ile Val Arg Lys Glu Met Asn 
        435                 440                 445         

<210>   3257
<211>   780
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3257
atggtttata cttcactttc ctcaaaagat ggcaattacc cctatcagct caacattgcc   60
cacctctacg gaaatctcat gaatacctac ggggacaatg gaaacatcct catgctcaag   120
tatgtggctg aaaaactggg agcccatgtg accgttgaca tcgtttctct ccatgatgac   180
tttgatgaaa atcactacga catcgccttt ttcggtggtg gtcaagactt tgaacaaagt   240
atcattgcag acgacctacc tgctaaaaaa gagagcattg acaactacat ccaaaacgac   300
ggtgtagttc tggctatctg cggtggtttc caactattgg gtcaatatta tgttgaagct   360
tcaggaaaac gtatcgaagg gctaggggtc atgggacact acacgctcaa ccagaccaat   420
aaccgtttta tcggtgacat caagattcac aatgaagatt tcgatgaaac ctactatgga   480
tttgaaaatc accaaggtcg taccttcctc tctgatgacc aaaaaccgct gggacaggtt   540
gtctatggaa atggaaacaa cgaagaaaag gtcggtgaag gggttcatta taagaatgtc   600
tttggttcct acttccacgg gcctatcctc tctcgtaatg ccaatctggc ttatcgccta   660
gttactactg ccctcaagaa gaaatatggt caggacatcc aactccctgc ctatgaggac   720
attctcagcc aagaaatcgc tgaagagtac agtgacgtca aaagcaaggc tgacttttct   780

<210>   3258
<211>   260
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903487 (e-154)

<400>   3258
Met Val Tyr Thr Ser Leu Ser Ser Lys Asp Gly Asn Tyr Pro Tyr Gln 
1               5                   10                  15      

Leu Asn Ile Ala His Leu Tyr Gly Asn Leu Met Asn Thr Tyr Gly Asp 
            20                  25                  30          

Asn Gly Asn Ile Leu Met Leu Lys Tyr Val Ala Glu Lys Leu Gly Ala 
        35                  40                  45              

His Val Thr Val Asp Ile Val Ser Leu His Asp Asp Phe Asp Glu Asn 
    50                  55                  60                  

His Tyr Asp Ile Ala Phe Phe Gly Gly Gly Gln Asp Phe Glu Gln Ser 
65                  70                  75                  80  

Ile Ile Ala Asp Asp Leu Pro Ala Lys Lys Glu Ser Ile Asp Asn Tyr 
                85                  90                  95      

Ile Gln Asn Asp Gly Val Val Leu Ala Ile Cys Gly Gly Phe Gln Leu 
            100                 105                 110         

Leu Gly Gln Tyr Tyr Val Glu Ala Ser Gly Lys Arg Ile Glu Gly Leu 
        115                 120                 125             

Gly Val Met Gly His Tyr Thr Leu Asn Gln Thr Asn Asn Arg Phe Ile 
    130                 135                 140                 

Gly Asp Ile Lys Ile His Asn Glu Asp Phe Asp Glu Thr Tyr Tyr Gly 
145                 150                 155                 160 

Phe Glu Asn His Gln Gly Arg Thr Phe Leu Ser Asp Asp Gln Lys Pro 
                165                 170                 175     

Leu Gly Gln Val Val Tyr Gly Asn Gly Asn Asn Glu Glu Lys Val Gly 
            180                 185                 190         

Glu Gly Val His Tyr Lys Asn Val Phe Gly Ser Tyr Phe His Gly Pro 
        195                 200                 205             

Ile Leu Ser Arg Asn Ala Asn Leu Ala Tyr Arg Leu Val Thr Thr Ala 
    210                 215                 220                 

Leu Lys Lys Lys Tyr Gly Gln Asp Ile Gln Leu Pro Ala Tyr Glu Asp 
225                 230                 235                 240 

Ile Leu Ser Gln Glu Ile Ala Glu Glu Tyr Ser Asp Val Lys Ser Lys 
                245                 250                 255     

Ala Asp Phe Ser 
            260 

<210>   3259
<211>   1080
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3259
atgtctaaat tacaacaaat cctaacatat cttgaatcag aaaaactaga cgtcgctgtc   60
gtatctgacc ccgtcacaat caattacctc actggttttt acagtgatcc ccatgaacgc   120
caaatgttcc tctttgtcct agcagatcag gaacctctcc tctttgtccc agctcttgaa   180
gtagaacgtg caagtagcac cgtttccttc ccagtagtgg gctatgtcga ttctgaaaat   240
ccatggcaaa aaatcaaaca tgctcttcca caacttgact tcaaacgtgt cgctgttgag   300
tttgacaatc tcatcttgac caaataccat ggtttgaaaa cagtttttga gactgctgag   360
tttgacaacc tcactcctcg tatccaacgc atgcgcctca tcaaatcagc tgatgaagtg   420
caaaaaatga tggttgcagg tctttatgct gacaaggctg ttcatgttgg ttttgacaat   480
atttctcttg ataagactga gacagatatc atcgcacaaa tcgactttgc catgaaacgt   540
gaaggttatg aaatgagctt tgataccatg gtcttgactg gtgataatgc tgcgaatcca   600
cacggcattc cagcagctaa taaggttgaa aatgatgctc ttctcctctt tgacctgggt   660
gttctggtca atggctatgc gtcagatatg actcgtacag tcgctgtcgg caaaccagac   720
caattcaaga aagatattta caacttgact cttgaagccc aacaagctgc tcttgacttt   780
atcaagccag gtgtgactgc tcatgaagtg gaccgcgctg cccgtgaggt catcgaaaaa   840
gctggttatg gtgagtactt caaccaccgt ctcgggcatg gtatcggtat ggatgtccat   900
gaattcccat ctatcatgga aggaaacgac atggtcatcg aagaaggcat gtgcttctct   960
gttgaaccag gtatctatat ccctggtaaa gtcggtgttc gtattgaaga ctgcggtgtt   1020
gttaccaagg atggcttcaa cctctttaca agcaccagca aagatttgct ttattttgat   1080

<210>   3260
<211>   360
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   proline dipeptidase (pepQ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903488 (0.E+01)

<400>   3260
Met Ser Lys Leu Gln Gln Ile Leu Thr Tyr Leu Glu Ser Glu Lys Leu 
1               5                   10                  15      

Asp Val Ala Val Val Ser Asp Pro Val Thr Ile Asn Tyr Leu Thr Gly 
            20                  25                  30          

Phe Tyr Ser Asp Pro His Glu Arg Gln Met Phe Leu Phe Val Leu Ala 
        35                  40                  45              

Asp Gln Glu Pro Leu Leu Phe Val Pro Ala Leu Glu Val Glu Arg Ala 
    50                  55                  60                  

Ser Ser Thr Val Ser Phe Pro Val Val Gly Tyr Val Asp Ser Glu Asn 
65                  70                  75                  80  

Pro Trp Gln Lys Ile Lys His Ala Leu Pro Gln Leu Asp Phe Lys Arg 
                85                  90                  95      

Val Ala Val Glu Phe Asp Asn Leu Ile Leu Thr Lys Tyr His Gly Leu 
            100                 105                 110         

Lys Thr Val Phe Glu Thr Ala Glu Phe Asp Asn Leu Thr Pro Arg Ile 
        115                 120                 125             

Gln Arg Met Arg Leu Ile Lys Ser Ala Asp Glu Val Gln Lys Met Met 
    130                 135                 140                 

Val Ala Gly Leu Tyr Ala Asp Lys Ala Val His Val Gly Phe Asp Asn 
145                 150                 155                 160 

Ile Ser Leu Asp Lys Thr Glu Thr Asp Ile Ile Ala Gln Ile Asp Phe 
                165                 170                 175     

Ala Met Lys Arg Glu Gly Tyr Glu Met Ser Phe Asp Thr Met Val Leu 
            180                 185                 190         

Thr Gly Asp Asn Ala Ala Asn Pro His Gly Ile Pro Ala Ala Asn Lys 
        195                 200                 205             

Val Glu Asn Asp Ala Leu Leu Leu Phe Asp Leu Gly Val Leu Val Asn 
    210                 215                 220                 

Gly Tyr Ala Ser Asp Met Thr Arg Thr Val Ala Val Gly Lys Pro Asp 
225                 230                 235                 240 

Gln Phe Lys Lys Asp Ile Tyr Asn Leu Thr Leu Glu Ala Gln Gln Ala 
                245                 250                 255     

Ala Leu Asp Phe Ile Lys Pro Gly Val Thr Ala His Glu Val Asp Arg 
            260                 265                 270         

Ala Ala Arg Glu Val Ile Glu Lys Ala Gly Tyr Gly Glu Tyr Phe Asn 
        275                 280                 285             

His Arg Leu Gly His Gly Ile Gly Met Asp Val His Glu Phe Pro Ser 
    290                 295                 300                 

Ile Met Glu Gly Asn Asp Met Val Ile Glu Glu Gly Met Cys Phe Ser 
305                 310                 315                 320 

Val Glu Pro Gly Ile Tyr Ile Pro Gly Lys Val Gly Val Arg Ile Glu 
                325                 330                 335     

Asp Cys Gly Val Val Thr Lys Asp Gly Phe Asn Leu Phe Thr Ser Thr 
            340                 345                 350         

Ser Lys Asp Leu Leu Tyr Phe Asp 
        355                 360 

<210>   3261
<211>   201
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3261
ttgattaaac tatatagccc ctatgctttc ctttcaaaat atctaggggc tattttattg   60
tcatttttct gctattatgc taaagaaatt ggctgcaata atctaaccct aagtgtctgg   120
aatgataacg agggtgctct ccgcttttat caaagacaag ggatgaaacc ccaagaaaca   180
acaatggaaa tgataattga t                                             201

<210>   3262
<211>   67
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm

<400>   3262
Met Ile Lys Leu Tyr Ser Pro Tyr Ala Phe Leu Ser Lys Tyr Leu Gly 
1               5                   10                  15      

Ala Ile Leu Leu Ser Phe Phe Cys Tyr Tyr Ala Lys Glu Ile Gly Cys 
            20                  25                  30          

Asn Asn Leu Thr Leu Ser Val Trp Asn Asp Asn Glu Gly Ala Leu Arg 
        35                  40                  45              

Phe Tyr Gln Arg Gln Gly Met Lys Pro Gln Glu Thr Thr Met Glu Met 
    50                  55                  60                  

Ile Ile Asp 
65          

<210>   3263
<211>   339
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3263
atgttggaac aggcattcaa agagaagcac tacgagaata cgattctcca tagtgaccaa   60
ggctggcaat accaacacga ttcttatcat cggttcctag agaataaggg aattcaagca   120
tctatgtcac gcaagggaaa cagccaagac aacggtatga tggaatcttt ctttggcatt   180
ttaaaatccg aaatgtttta tggctatgag aaaacattta aatcacttaa ccaattggaa   240
caagtcatta tagactatat tgattactac aacaacaaac gaattaaggt aaaactaaaa   300
ggacttagtc ctgtgcagta cagaactaaa tccttcgga                          339

<210>   3264
<211>   113
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA transposase

<400>   3264
Met Leu Glu Gln Ala Phe Lys Glu Lys His Tyr Glu Asn Thr Ile Leu 
1               5                   10                  15      

His Ser Asp Gln Gly Trp Gln Tyr Gln His Asp Ser Tyr His Arg Phe 
            20                  25                  30          

Leu Glu Asn Lys Gly Ile Gln Ala Ser Met Ser Arg Lys Gly Asn Ser 
        35                  40                  45              

Gln Asp Asn Gly Met Met Glu Ser Phe Phe Gly Ile Leu Lys Ser Glu 
    50                  55                  60                  

Met Phe Tyr Gly Tyr Glu Lys Thr Phe Lys Ser Leu Asn Gln Leu Glu 
65                  70                  75                  80  

Gln Val Ile Ile Asp Tyr Ile Asp Tyr Tyr Asn Asn Lys Arg Ile Lys 
                85                  90                  95      

Val Lys Leu Lys Gly Leu Ser Pro Val Gln Tyr Arg Thr Lys Ser Phe 
            100                 105                 110         

Gly 
    

<210>   3265
<211>   235
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3265
aataaagtct gacatgaagg ctggactaaa gatagagttt ctcttgaata cggtctccca   60
agtcgtacga tacttcttaa ctggctagca caatacagga aaaacgggta tactattgtt   120
gagaaaacaa gagggagagt acctgagagc ggagaatgcc atcctaaaaa agttaagaga   180
actccgattg aaggaggaaa aagagaaaga agaaagacag aaattgttca agaat        235

<210>   3266
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, hypothetical protein, interruption

<400>   3266
Met Leu Arg Lys Gln Glu Gly Glu Tyr Leu Arg Ala Glu Asn Ala Ile 
1               5                   10                  15      

Leu Lys Lys Leu Arg Glu Leu Arg Leu Lys Glu Glu Lys Glu Lys Glu 
            20                  25                  30          

Glu Arg Gln Lys Leu Phe Lys Asn 
        35                  40  

<210>   3267
<211>   831
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3267
atgactgagt tttcgttaga tcttcttcta gaagccatta aactagctcg ttggacctac   60
tactatcact tgaaacagct agacaaaaca gataaagacc aagagcttaa aactgaaatt   120
caatccatct ttatcgaaca caagggaaat tatgcttatc gccgggttca tttagaacta   180
agaaatcgtg gttatctggt aaatcataaa agagttcaag gcttgatgaa agtactcaat   240
ttacaagcta aaatgcgaaa gaaacgaaaa tattcttctc ataaaggaga cgttggtaag   300
aaggcagaga atctcattca agcccaattt gaaggctcta aaacaatgga aaagtgctac   360
acagatgtga ctgaatttgc cattccagca agtactcaaa agctttactt atcaccagtt   420
ttagatggct ttaacagcga aattattgct tttaatcttt cttgttcgcc taatttagaa   480
taagtacaaa caatgttgga acaggcattc aaagagaagc actacgagaa tacgattctc   540
catagtgacc aaggctggca ataccaacac gattcttatc atcggttcct agagaataag   600
ggaattcaag catctatgtc acgcaaggga aacagccaag acaacggtat gatggaatct   660
ttctttggca ttttaaaatc cgaaatgttt tatggctatg agaaaacatt taaatcactt   720
aaccaattgg aacaagtcat tatagactat attgattact acaacaacaa acgaattaag   780
gtaaaactaa aaggacttag tcctgtgcag tacagaacta aatccttcgg a            831

<210>   3268
<211>   160
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, transposase POINT MUTATION

<400>   3268
Met Thr Glu Phe Ser Leu Asp Leu Leu Leu Glu Ala Ile Lys Leu Ala 
1               5                   10                  15      

Arg Trp Thr Tyr Tyr Tyr His Leu Lys Gln Leu Asp Lys Thr Asp Lys 
            20                  25                  30          

Asp Gln Glu Leu Lys Thr Glu Ile Gln Ser Ile Phe Ile Glu His Lys 
        35                  40                  45              

Gly Asn Tyr Ala Tyr Arg Arg Val His Leu Glu Leu Arg Asn Arg Gly 

    50                  55                  60                  

Tyr Leu Val Asn His Lys Arg Val Gln Gly Leu Met Lys Val Leu Asn 
65                  70                  75                  80  

Leu Gln Ala Lys Met Arg Lys Lys Arg Lys Tyr Ser Ser His Lys Gly 
                85                  90                  95      

Asp Val Gly Lys Lys Ala Glu Asn Leu Ile Gln Ala Gln Phe Glu Gly 
            100                 105                 110         

Ser Lys Thr Met Glu Lys Cys Tyr Thr Asp Val Thr Glu Phe Ala Ile 
        115                 120                 125             

Pro Ala Ser Thr Gln Lys Leu Tyr Leu Ser Pro Val Leu Asp Gly Phe 
    130                 135                 140                 

Asn Ser Glu Ile Ile Ala Phe Asn Leu Ser Cys Ser Pro Asn Leu Glu 
145                 150                 155                 160 


<210>   3269
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3269
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattgtt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg tgggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   3270
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903941 (2.E-46)

<400>   3270
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   3271
<211>   459
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3271
atgaagcaaa caaaaacaac taaaatcgcc cttgtatccc tattaaccgc cctttctgtg   60
gttctaggtt atttcttaaa aatcccaaca cctacaggaa ttctaactct tttagatgct   120
ggtgtcttct ttgcggcctt ttactttggt agtcgtgaag gagcggtagt cggaggacta   180
gcaagtttct tgattgacct cttatcaggc taccctcagt ggatgttctt tagcttggtc   240
aaccatggct tgcagggatt tttcgcagga tttaaaggaa aaagtcagtg gttaggcctt   300
attttagcaa ctattgccat ggtaggaggc tacgccttgg gttctgcttt gatgaatggc   360
tgggcagcag ccctcccaga aattctaccg aattttatgc aaaatatggt agggatgatt   420
gtaggattta ttcttagtca aagtatcaag aagattaag                          459

<210>   3272
<211>   153
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   3272
Met Lys Gln Thr Lys Thr Thr Lys Ile Ala Leu Val Ser Leu Leu Thr 
1               5                   10                  15      

Ala Leu Ser Val Val Leu Gly Tyr Phe Leu Lys Ile Pro Thr Pro Thr 
            20                  25                  30          

Gly Ile Leu Thr Leu Leu Asp Ala Gly Val Phe Phe Ala Ala Phe Tyr 
        35                  40                  45              

Phe Gly Ser Arg Glu Gly Ala Val Val Gly Gly Leu Ala Ser Phe Leu 
    50                  55                  60                  

Ile Asp Leu Leu Ser Gly Tyr Pro Gln Trp Met Phe Phe Ser Leu Val 
65                  70                  75                  80  

Asn His Gly Leu Gln Gly Phe Phe Ala Gly Phe Lys Gly Lys Ser Gln 
                85                  90                  95      

Trp Leu Gly Leu Ile Leu Ala Thr Ile Ala Met Val Gly Gly Tyr Ala 
            100                 105                 110         

Leu Gly Ser Ala Leu Met Asn Gly Trp Ala Ala Ala Leu Pro Glu Ile 
        115                 120                 125             

Leu Pro Asn Phe Met Gln Asn Met Val Gly Met Ile Val Gly Phe Ile 
    130                 135                 140                 

Leu Ser Gln Ser Ile Lys Lys Ile Lys 
145                 150             

<210>   3273
<211>   771
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3273
atgaagaata atcgtatttt agcactttct ggaaatgata tttttagtgg tggtggactg   60
tcagctgatt tggctaccta taccttgaac ggcttgcatg ggtttgtagc agtgacttgt   120
ttgacagcct tgacagaaaa aggatttgaa gtctttccaa ctgatgatac catttttcaa   180
catgaattag atagcttgcg tgatgtggaa tttgggggaa ttaagattgg tcttctccct   240
actgtcagcg tggctgagaa ggccttggac tttatcaaac aacgcccagg agtacctgtg   300
gtgttggatc ctgtcttggt ctgcaaggaa acgcatgatg tagctgtcag tgagctctgc   360
caagagttga ttcgcttttt cccttatgtc agtgtgatta cgcctaatct cccagaagca   420
gaattattat ccggtcagga aattaaaacc ttggaagaca tgaaaactgc agcgcagaaa   480
ttgcatgatt taggagcgcc agcagtcatt atcaagggag gcaatcgtct tagtcaggac   540
aaggctgtgg atgtctttta tgatggacag acctttacta tcctagaaaa tccagttatc   600
caaggccaaa atgctggtgc aggttgtacc tttgcctcta gcattgccag tcacctggtt   660
aaaggtgata aacttttgcc agcagtagaa agctctaagg ctttcgttta tcgtgctatt   720
gcacaagcag atcagtatgg agtaagacaa tatgaagcaa acaaaaacaa c            771

<210>   3274
<211>   257
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphomethylpyrimidine kinase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903493 (e-145)

<400>   3274
Met Lys Asn Asn Arg Ile Leu Ala Leu Ser Gly Asn Asp Ile Phe Ser 
1               5                   10                  15      

Gly Gly Gly Leu Ser Ala Asp Leu Ala Thr Tyr Thr Leu Asn Gly Leu 
            20                  25                  30          

His Gly Phe Val Ala Val Thr Cys Leu Thr Ala Leu Thr Glu Lys Gly 
        35                  40                  45              

Phe Glu Val Phe Pro Thr Asp Asp Thr Ile Phe Gln His Glu Leu Asp 
    50                  55                  60                  

Ser Leu Arg Asp Val Glu Phe Gly Gly Ile Lys Ile Gly Leu Leu Pro 
65                  70                  75                  80  


Thr Val Ser Val Ala Glu Lys Ala Leu Asp Phe Ile Lys Gln Arg Pro 
                85                  90                  95      

Gly Val Pro Val Val Leu Asp Pro Val Leu Val Cys Lys Glu Thr His 
            100                 105                 110         

Asp Val Ala Val Ser Glu Leu Cys Gln Glu Leu Ile Arg Phe Phe Pro 
        115                 120                 125             

Tyr Val Ser Val Ile Thr Pro Asn Leu Pro Glu Ala Glu Leu Leu Ser 
    130                 135                 140                 

Gly Gln Glu Ile Lys Thr Leu Glu Asp Met Lys Thr Ala Ala Gln Lys 
145                 150                 155                 160 

Leu His Asp Leu Gly Ala Pro Ala Val Ile Ile Lys Gly Gly Asn Arg 
                165                 170                 175     

Leu Ser Gln Asp Lys Ala Val Asp Val Phe Tyr Asp Gly Gln Thr Phe 
            180                 185                 190         

Thr Ile Leu Glu Asn Pro Val Ile Gln Gly Gln Asn Ala Gly Ala Gly 
        195                 200                 205             

Cys Thr Phe Ala Ser Ser Ile Ala Ser His Leu Val Lys Gly Asp Lys 
    210                 215                 220                 

Leu Leu Pro Ala Val Glu Ser Ser Lys Ala Phe Val Tyr Arg Ala Ile 
225                 230                 235                 240 

Ala Gln Ala Asp Gln Tyr Gly Val Arg Gln Tyr Glu Ala Asn Lys Asn 
                245                 250                 255     

Asn 
    

<210>   3275
<211>   747
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3275
atgacgagat ataaagcaac tatttcctat gatggttatg cctttgctgg ctttcagcgc   60
cagcctcatg cgcgtagcgt tcaggaagaa attgaaaaaa ccttgaccag attaaataaa   120
gggcaagcca ttactgttca cggtgctggt aggacagata gtggggttca tgccctggga   180
caggtgattc attttgacct gccttatcag atggatgagg agaaactccg ttttgccttg   240
gatacccagt ctcctgaaga tattgatgtg atttcgattg agcttgtggc agatgatttt   300
cattgccgtt atgccaagca tagcaagacc tatgagttta ctgtggatag aggacgtccc   360
aaaaatccga tgcgccgtca ctatgccacc cactttccct acccactcga tgtggaacga   420
atgcagattg caatcaaaaa gctagaggga acccatgatt ttaccggttt tacagcctct   480
gggactagtg tagaggataa ggttcgcacc atcacagaag ctagtttaat agtcgatgag   540
acaggacaat ttttgacctt taccttttca ggaaatggtt tcttgtataa acagattcgc   600
aatatggtgg ggactcttct caaaatcggt aacaaccgca tgccagtaga gcagattgat   660
ctcatcttgg agaagaagga caggcaactt gcaggtccca ctgcagcacc aaatggtttg   720
tatttaaagg agattcgtta tgaagaa                                       747

<210>   3276
<211>   249
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tRNA pseudouridine synthase A (truA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903494 (e-142)

<400>   3276
Met Thr Arg Tyr Lys Ala Thr Ile Ser Tyr Asp Gly Tyr Ala Phe Ala 
1               5                   10                  15      

Gly Phe Gln Arg Gln Pro His Ala Arg Ser Val Gln Glu Glu Ile Glu 
            20                  25                  30          

Lys Thr Leu Thr Arg Leu Asn Lys Gly Gln Ala Ile Thr Val His Gly 
        35                  40                  45              

Ala Gly Arg Thr Asp Ser Gly Val His Ala Leu Gly Gln Val Ile His 
    50                  55                  60                  

Phe Asp Leu Pro Tyr Gln Met Asp Glu Glu Lys Leu Arg Phe Ala Leu 
65                  70                  75                  80  

Asp Thr Gln Ser Pro Glu Asp Ile Asp Val Ile Ser Ile Glu Leu Val 
                85                  90                  95      

Ala Asp Asp Phe His Cys Arg Tyr Ala Lys His Ser Lys Thr Tyr Glu 
            100                 105                 110         

Phe Thr Val Asp Arg Gly Arg Pro Lys Asn Pro Met Arg Arg His Tyr 
        115                 120                 125             

Ala Thr His Phe Pro Tyr Pro Leu Asp Val Glu Arg Met Gln Ile Ala 
    130                 135                 140                 

Ile Lys Lys Leu Glu Gly Thr His Asp Phe Thr Gly Phe Thr Ala Ser 
145                 150                 155                 160 

Gly Thr Ser Val Glu Asp Lys Val Arg Thr Ile Thr Glu Ala Ser Leu 
                165                 170                 175     

Ile Val Asp Glu Thr Gly Gln Phe Leu Thr Phe Thr Phe Ser Gly Asn 
            180                 185                 190         

Gly Phe Leu Tyr Lys Gln Ile Arg Asn Met Val Gly Thr Leu Leu Lys 
        195                 200                 205             

Ile Gly Asn Asn Arg Met Pro Val Glu Gln Ile Asp Leu Ile Leu Glu 
    210                 215                 220                 

Lys Lys Asp Arg Gln Leu Ala Gly Pro Thr Ala Ala Pro Asn Gly Leu 
225                 230                 235                 240 

Tyr Leu Lys Glu Ile Arg Tyr Glu Glu 
                245                 

<210>   3277
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3277
ttgtatgggt ataaaaatct catactcttc gaaaatctct tcaaaccacg tcagtttcca   60
tctgcaacct caacacacta ttttgagcaa cctgcggcta gctttcta                108

<210>   3278
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3278
Met Tyr Gly Tyr Lys Asn Leu Ile Leu Phe Glu Asn Leu Phe Lys Pro 
1               5                   10                  15      

Arg Gln Phe Pro Ser Ala Thr Ser Thr His Tyr Phe Glu Gln Pro Ala 
            20                  25                  30          

Ala Ser Phe Leu 
        35      

<210>   3279
<211>   1149
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3279
atgaaacaat ttttagaacg ggccagcatt ttggctctct ccctcgtttt gattacctcc   60
ttttccattt cgagtgccct accagccatg tttgactatt atcagggtta ttctaaggaa   120
caaattgagc tcttggtgag cttgccttcc tttggaatca tgatgatgtt actgctaaat   180
ggtttcttag aaaaaatatt tcctgagcgc ttacagatta gtttgggctt gctgatttta   240
tcattgagcg gtacagctcc cttctggtac caagcctatc cctttgtctt tggaacacgg   300
cttctctttg gtttgggtct tgggatgatc aatgccaagg ccatttctat tatcagtgaa   360
cgctaccaag gaaaaaggcg aattcagatg ttagggctac gcgcttctgc agaggtcgtt   420
ggagcttctc tcattacctt ggccgtcggt cagttgttgg cctttggttg gacagctatc   480
tttctagcct atagtgctgg atttttggtg ctgccccttt atctgctctt tgtcccttat   540
ggaaaatcaa agaaagaagt caagaaaaga gcgaaggaag caagtcgttt aactcgagaa   600
atgaaaggct tgatttttac cttagctatc gaagcggcag ttgtagtttg taccaataca   660
gctattacca tccgtattcc aagtttgatg gtggaaagag gattggggga tgcccagtta   720
tctagttttg ttcttagtat catgcagttg atcgggattg tggctggggt gagtttttct   780
ttcttgattt ctatctttaa agagaaactg ctcctctggt ctggtattac ctttggcttg   840
gggcaaatcg tgattgcctt gtcttcatcc ttgtgggtgg tagtagcagg aagtgttctg   900
gctggatttg cctatagtgt agtcttgacg acggtctttc aacttgtctc tgaacgaatt   960
ccagctaaac tcctcaatca agcaacttca tttgctgtat taggctgtag tttcggagcc   1020
tttacgaccc cattcgttct aggtgcaatt ggcttactaa ctcacaatgg gatgttggtc   1080
tttagtatct taggaggttg gttgattgta atctctatct ttgtcatgta cctacttcag   1140
aagagagct                                                           1149

<210>   3280
<211>   383
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Major facilitator)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903496 (0.E+01)

<400>   3280
Met Lys Gln Phe Leu Glu Arg Ala Ser Ile Leu Ala Leu Ser Leu Val 
1               5                   10                  15      

Leu Ile Thr Ser Phe Ser Ile Ser Ser Ala Leu Pro Ala Met Phe Asp 
            20                  25                  30          

Tyr Tyr Gln Gly Tyr Ser Lys Glu Gln Ile Glu Leu Leu Val Ser Leu 
        35                  40                  45              

Pro Ser Phe Gly Ile Met Met Met Leu Leu Leu Asn Gly Phe Leu Glu 
    50                  55                  60                  

Lys Ile Phe Pro Glu Arg Leu Gln Ile Ser Leu Gly Leu Leu Ile Leu 
65                  70                  75                  80  

Ser Leu Ser Gly Thr Ala Pro Phe Trp Tyr Gln Ala Tyr Pro Phe Val 
                85                  90                  95      

Phe Gly Thr Arg Leu Leu Phe Gly Leu Gly Leu Gly Met Ile Asn Ala 
            100                 105                 110         

Lys Ala Ile Ser Ile Ile Ser Glu Arg Tyr Gln Gly Lys Arg Arg Ile 
        115                 120                 125             

Gln Met Leu Gly Leu Arg Ala Ser Ala Glu Val Val Gly Ala Ser Leu 
    130                 135                 140                 

Ile Thr Leu Ala Val Gly Gln Leu Leu Ala Phe Gly Trp Thr Ala Ile 
145                 150                 155                 160 


Phe Leu Ala Tyr Ser Ala Gly Phe Leu Val Leu Pro Leu Tyr Leu Leu 
                165                 170                 175     

Phe Val Pro Tyr Gly Lys Ser Lys Lys Glu Val Lys Lys Arg Ala Lys 
            180                 185                 190         

Glu Ala Ser Arg Leu Thr Arg Glu Met Lys Gly Leu Ile Phe Thr Leu 
        195                 200                 205             

Ala Ile Glu Ala Ala Val Val Val Cys Thr Asn Thr Ala Ile Thr Ile 
    210                 215                 220                 

Arg Ile Pro Ser Leu Met Val Glu Arg Gly Leu Gly Asp Ala Gln Leu 
225                 230                 235                 240 

Ser Ser Phe Val Leu Ser Ile Met Gln Leu Ile Gly Ile Val Ala Gly 
                245                 250                 255     

Val Ser Phe Ser Phe Leu Ile Ser Ile Phe Lys Glu Lys Leu Leu Leu 
            260                 265                 270         

Trp Ser Gly Ile Thr Phe Gly Leu Gly Gln Ile Val Ile Ala Leu Ser 
        275                 280                 285             

Ser Ser Leu Trp Val Val Val Ala Gly Ser Val Leu Ala Gly Phe Ala 
    290                 295                 300                 

Tyr Ser Val Val Leu Thr Thr Val Phe Gln Leu Val Ser Glu Arg Ile 
305                 310                 315                 320 

Pro Ala Lys Leu Leu Asn Gln Ala Thr Ser Phe Ala Val Leu Gly Cys 
                325                 330                 335     

Ser Phe Gly Ala Phe Thr Thr Pro Phe Val Leu Gly Ala Ile Gly Leu 
            340                 345                 350         

Leu Thr His Asn Gly Met Leu Val Phe Ser Ile Leu Gly Gly Trp Leu 
        355                 360                 365             

Ile Val Ile Ser Ile Phe Val Met Tyr Leu Leu Gln Lys Arg Ala 
    370                 375                 380             

<210>   3281
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3281
atgtcaaaac actataaact tgtattttat agccgtatct tcttgtttct agcggctttt   60
acgggagttt atcttgaaat tactaagcat ggtggttttg ggatgcttct ctattacacg   120
gttctgtcca acctcttggt aactattttt accctttatc ttctaaaggt tatgagccgt   180
gtaggtgaaa attggcaaag gccaagtctc ttgcgcttaa aaggtggggt caccatgagt   240
atcatgatta cctgtgtgat ttaccatttc ctcttggcgc ccattgcgac taatttctat   300
accctagaaa atttcctttg ccactatatc gttcccatct ggtttttagc ggataccctc   360
ttttttgaca aacagggtca atacaagatt tgggatccag cagtgtggac cattttaccc   420
tttctgtata tgatgtttgc tctttttaat ggcttggttc taaaactcaa tattccaaat   480
gccaaggata atcctttccc ttacttcttt ttgaatgtga acaagggttg gaatgttgtg   540
tttaagtggt gtctgattat ctttgttgcc tatatggtag caggatttat tttctacttt   600
atcaagcaaa tcaagagaaa gtcatcc                                       627

<210>   3282
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903497 (e-123)

<400>   3282
Met Ser Lys His Tyr Lys Leu Val Phe Tyr Ser Arg Ile Phe Leu Phe 
1               5                   10                  15      

Leu Ala Ala Phe Thr Gly Val Tyr Leu Glu Ile Thr Lys His Gly Gly 
            20                  25                  30          

Phe Gly Met Leu Leu Tyr Tyr Thr Val Leu Ser Asn Leu Leu Val Thr 
        35                  40                  45              

Ile Phe Thr Leu Tyr Leu Leu Lys Val Met Ser Arg Val Gly Glu Asn 
    50                  55                  60                  

Trp Gln Arg Pro Ser Leu Leu Arg Leu Lys Gly Gly Val Thr Met Ser 
65                  70                  75                  80  

Ile Met Ile Thr Cys Val Ile Tyr His Phe Leu Leu Ala Pro Ile Ala 
                85                  90                  95      

Thr Asn Phe Tyr Thr Leu Glu Asn Phe Leu Cys His Tyr Ile Val Pro 
            100                 105                 110         

Ile Trp Phe Leu Ala Asp Thr Leu Phe Phe Asp Lys Gln Gly Gln Tyr 
        115                 120                 125             

Lys Ile Trp Asp Pro Ala Val Trp Thr Ile Leu Pro Phe Leu Tyr Met 
    130                 135                 140                 

Met Phe Ala Leu Phe Asn Gly Leu Val Leu Lys Leu Asn Ile Pro Asn 
145                 150                 155                 160 

Ala Lys Asp Asn Pro Phe Pro Tyr Phe Phe Leu Asn Val Asn Lys Gly 
                165                 170                 175     

Trp Asn Val Val Phe Lys Trp Cys Leu Ile Ile Phe Val Ala Tyr Met 
            180                 185                 190         

Val Ala Gly Phe Ile Phe Tyr Phe Ile Lys Gln Ile Lys Arg Lys Ser 
        195                 200                 205             

Ser 
    

<210>   3283
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3283
atgaacaatt taccaaattg tccaaaatgt aactcagagt atgtctacga agacggtgcc   60
ctactggttt gcccagagtg tgctcatgag tggaatcctg ctgaagttgc agaagtagaa   120
gaaggtcttg tcgctatcga tgccaacgga aataaattgg ctgatggtga tacagtaact   180
ctcatcaagg acttgaaagt aaaaggtgcg ccaaaagatt tgaaacaagg gacgcgcgtg   240
aaaaatatcc gcatcgtaga aggcgaccac aatatcgact gtaagattga tggttttggt   300
gccatgaaac ttaaatcaga gtttgtgagg aagatt                             336

<210>   3284
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phnA protein (phnA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903498 (2.E-63)

<400>   3284
Met Asn Asn Leu Pro Asn Cys Pro Lys Cys Asn Ser Glu Tyr Val Tyr 
1               5                   10                  15      

Glu Asp Gly Ala Leu Leu Val Cys Pro Glu Cys Ala His Glu Trp Asn 
            20                  25                  30          

Pro Ala Glu Val Ala Glu Val Glu Glu Gly Leu Val Ala Ile Asp Ala 
        35                  40                  45              

Asn Gly Asn Lys Leu Ala Asp Gly Asp Thr Val Thr Leu Ile Lys Asp 
    50                  55                  60                  

Leu Lys Val Lys Gly Ala Pro Lys Asp Leu Lys Gln Gly Thr Arg Val 
65                  70                  75                  80  

Lys Asn Ile Arg Ile Val Glu Gly Asp His Asn Ile Asp Cys Lys Ile 
                85                  90                  95      

Asp Gly Phe Gly Ala Met Lys Leu Lys Ser Glu Phe Val Arg Lys Ile 
            100                 105                 110         


<210>   3285
<211>   669
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3285
atgaaaacaa ttcaaattgc tattgatggt cctgcttcca gcggtaagag tacggtcgca   60
aagattattg ctaaggattt tggattcacc taccttgata caggagctat gtatcgtgca   120
gcgacctata tggctcttaa gaaccaatta ggagttgaag aagtcgaagc ccttctagcc   180
ttgttggacc agcatccaat cagctttgga cgttcagaaa ctggagacca gcttgttttt   240
gtaggagatg tggatattac ccatcctatc cgtgaaaatg aagtgaccaa tcatgtttct   300
gctattgcag caattcctca agtgcgtgag aaactggttt ctctccaaca agaaattgcc   360
cagcaaggcg ggattgtcat ggatggtcgc gatattggaa ctgttgtatt gccacaagca   420
gaattgaaaa ttttcctagt agcttctgtt gatgagagag cagagcgtcg ttacaaggaa   480
aatattgcca agggaattga aacagacctt gaaaccctaa aaaaggaaat tgctgcgcgt   540
gactacaagg atagtcatcg tgagacttct cctctcaaac aagcagagga tgctgtctac   600
cttgatacaa ctggtttgaa cattcaagaa gtagttgaaa aaatcaaagc agaagctgaa   660
aaaagaatg                                                           669

<210>   3286
<211>   223
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cytidylate kinase (cmk)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903499 (e-121)

<400>   3286
Met Lys Thr Ile Gln Ile Ala Ile Asp Gly Pro Ala Ser Ser Gly Lys 
1               5                   10                  15      

Ser Thr Val Ala Lys Ile Ile Ala Lys Asp Phe Gly Phe Thr Tyr Leu 
            20                  25                  30          

Asp Thr Gly Ala Met Tyr Arg Ala Ala Thr Tyr Met Ala Leu Lys Asn 
        35                  40                  45              

Gln Leu Gly Val Glu Glu Val Glu Ala Leu Leu Ala Leu Leu Asp Gln 
    50                  55                  60                  

His Pro Ile Ser Phe Gly Arg Ser Glu Thr Gly Asp Gln Leu Val Phe 
65                  70                  75                  80  

Val Gly Asp Val Asp Ile Thr His Pro Ile Arg Glu Asn Glu Val Thr 
                85                  90                  95      

Asn His Val Ser Ala Ile Ala Ala Ile Pro Gln Val Arg Glu Lys Leu 
            100                 105                 110         

Val Ser Leu Gln Gln Glu Ile Ala Gln Gln Gly Gly Ile Val Met Asp 
        115                 120                 125             

Gly Arg Asp Ile Gly Thr Val Val Leu Pro Gln Ala Glu Leu Lys Ile 
    130                 135                 140                 

Phe Leu Val Ala Ser Val Asp Glu Arg Ala Glu Arg Arg Tyr Lys Glu 
145                 150                 155                 160 

Asn Ile Ala Lys Gly Ile Glu Thr Asp Leu Glu Thr Leu Lys Lys Glu 
                165                 170                 175     

Ile Ala Ala Arg Asp Tyr Lys Asp Ser His Arg Glu Thr Ser Pro Leu 
            180                 185                 190         

Lys Gln Ala Glu Asp Ala Val Tyr Leu Asp Thr Thr Gly Leu Asn Ile 
        195                 200                 205             

Gln Glu Val Val Glu Lys Ile Lys Ala Glu Ala Glu Lys Arg Met 
    210                 215                 220             

<210>   3287
<211>   474
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3287
atggcaaaag aaccgtggca agaagatatc tatgatcaag aagaatcaag agcagagcgt   60
cggcatcgaa accacggagg ggctgatagg atggctaatc gtattttgac gatcctagct   120
agtattttct ttgtaattgt ggtggtgatg gtcatcgttc tcatctatct atcatcgggg   180
gggagtaatc gcacagcagc cttaaaaggc tttcatgatt ctgatgccag tgtagtacaa   240
atctcatctt caagtagttc tcagcctgag cagagttcag agccagaatc tacttctagt   300
agttcagaag aagctgctaa tcctgaagga acgattaaag ttctcgcagg agaaggggaa   360
gcagctattg ccgctcgtgc aggaatctcc attgctcagt tagaggcctt gaatcctggg   420
cacatggcta caggatcttg gtttgctaat ccaggtgatg ttataaaaat aaaa         474

<210>   3288
<211>   158
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903500 (1.E-83)

<400>   3288
Met Ala Lys Glu Pro Trp Gln Glu Asp Ile Tyr Asp Gln Glu Glu Ser 
1               5                   10                  15      

Arg Ala Glu Arg Arg His Arg Asn His Gly Gly Ala Asp Arg Met Ala 
            20                  25                  30          

Asn Arg Ile Leu Thr Ile Leu Ala Ser Ile Phe Phe Val Ile Val Val 
        35                  40                  45              

Val Met Val Ile Val Leu Ile Tyr Leu Ser Ser Gly Gly Ser Asn Arg 
    50                  55                  60                  

Thr Ala Ala Leu Lys Gly Phe His Asp Ser Asp Ala Ser Val Val Gln 
65                  70                  75                  80  

Ile Ser Ser Ser Ser Ser Ser Gln Pro Glu Gln Ser Ser Glu Pro Glu 
                85                  90                  95      

Ser Thr Ser Ser Ser Ser Glu Glu Ala Ala Asn Pro Glu Gly Thr Ile 
            100                 105                 110         

Lys Val Leu Ala Gly Glu Gly Glu Ala Ala Ile Ala Ala Arg Ala Gly 
        115                 120                 125             

Ile Ser Ile Ala Gln Leu Glu Ala Leu Asn Pro Gly His Met Ala Thr 
    130                 135                 140                 

Gly Ser Trp Phe Ala Asn Pro Gly Asp Val Ile Lys Ile Lys 
145                 150                 155             

<210>   3289
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3289
atgaaaatca cacttatacc tgaacgatgt atcgcctgtg ggctttgcca aacttattct   60
gatttatttg attaccacga taatggaatc gtgcgttttt acgatgaccc tgaccaactg   120
gaaaaagaaa tttctcctag tcaggatatc ttagaggctg ttaaaaattg cccaactcgc   180
gccctgattg gaaaccagga agcc                                          204

<210>   3290
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ferredoxin (fer)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903501 (4.E-37)

<400>   3290
Met Lys Ile Thr Leu Ile Pro Glu Arg Cys Ile Ala Cys Gly Leu Cys 
1               5                   10                  15      

Gln Thr Tyr Ser Asp Leu Phe Asp Tyr His Asp Asn Gly Ile Val Arg 
            20                  25                  30          

Phe Tyr Asp Asp Pro Asp Gln Leu Glu Lys Glu Ile Ser Pro Ser Gln 
        35                  40                  45              

Asp Ile Leu Glu Ala Val Lys Asn Cys Pro Thr Arg Ala Leu Ile Gly 
    50                  55                  60                  

Asn Gln Glu Ala 
65              

<210>   3291
<211>   1017
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3291
gtgaagacgc atggcgttgg caaagcaagc atccaaatgg atttgaagac taagatgatg   60
atttcaatca tcgtcccttg tttaaacgaa gaggaagtac ttcctctttt ttatcaggct   120
ctggaagctt tacttccaga tttggaaaca gaaatcgagt atgtctttgt cgatgatgga   180
tcaagtgatg ggaccttgga actcttaaag gcctatcggg agcaaaatcc ggcagtccat   240
tatatttctt tctctcgaaa ttttggcaaa gaagcagccc tttatgcagg cttgcaatat   300
gcgacaggag atttggtggt ggtgatggat gcagacctcc aagatcctcc tagtatgttg   360
tttgagatga aaaatgtatt agacaaaaat gtagacttgg actgcgttgg gacacggaga   420
actagtcggg agggagaacc cttctttcgc agtttctgtg ctgttctctt ttatcgcctc   480
atgcaaaaaa tcagcccagt agctctgccg tcgggtgtcc gtgattttcg tatgatgaga   540
aggtctgtag tcgatgccat tttaagcttg accgagtcca atcgtttttc aaaggggctc   600
ttcgcctggg tgggtttcaa aacctactat ttggactatc caaatgtcga aaggcaggct   660
ggcaagacaa gttggagttt taggcaactc tttttctact ccattgaagg gattattaat   720
ttttcagatt ttcccttgat tatagccttt gtagctggtc tcctatcttg ttttctttct   780
ctgctgatga ccttttttgt tgtggttcgg accctcattt tgggcaatcc gacatctggt   840
tggacctctc tgatggctgt tattctcttt cttggaggca ttcaactctt gaccattggg   900
attctcggca agtatatcag taagatttat ttagagacta aaaaaagacc actttatctt   960
atcaaagaaa aaagtgacct tcctgatttt acagaaaaaa ataaagtgaa aagacta      1017

<210>   3292
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 2
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903502 (e-179)

<400>   3292
Met Lys Thr His Gly Val Gly Lys Ala Ser Ile Gln Met Asp Leu Lys 
1               5                   10                  15      

Thr Lys Met Met Ile Ser Ile Ile Val Pro Cys Leu Asn Glu Glu Glu 
            20                  25                  30          

Val Leu Pro Leu Phe Tyr Gln Ala Leu Glu Ala Leu Leu Pro Asp Leu 
        35                  40                  45              

Glu Thr Glu Ile Glu Tyr Val Phe Val Asp Asp Gly Ser Ser Asp Gly 
    50                  55                  60                  

Thr Leu Glu Leu Leu Lys Ala Tyr Arg Glu Gln Asn Pro Ala Val His 
65                  70                  75                  80  

Tyr Ile Ser Phe Ser Arg Asn Phe Gly Lys Glu Ala Ala Leu Tyr Ala 
                85                  90                  95      

Gly Leu Gln Tyr Ala Thr Gly Asp Leu Val Val Val Met Asp Ala Asp 
            100                 105                 110         

Leu Gln Asp Pro Pro Ser Met Leu Phe Glu Met Lys Asn Val Leu Asp 
        115                 120                 125             

Lys Asn Val Asp Leu Asp Cys Val Gly Thr Arg Arg Thr Ser Arg Glu 
    130                 135                 140                 

Gly Glu Pro Phe Phe Arg Ser Phe Cys Ala Val Leu Phe Tyr Arg Leu 
145                 150                 155                 160 

Met Gln Lys Ile Ser Pro Val Ala Leu Pro Ser Gly Val Arg Asp Phe 
                165                 170                 175     

Arg Met Met Arg Arg Ser Val Val Asp Ala Ile Leu Ser Leu Thr Glu 
            180                 185                 190         

Ser Asn Arg Phe Ser Lys Gly Leu Phe Ala Trp Val Gly Phe Lys Thr 
        195                 200                 205             

Tyr Tyr Leu Asp Tyr Pro Asn Val Glu Arg Gln Ala Gly Lys Thr Ser 
    210                 215                 220                 

Trp Ser Phe Arg Gln Leu Phe Phe Tyr Ser Ile Glu Gly Ile Ile Asn 
225                 230                 235                 240 

Phe Ser Asp Phe Pro Leu Ile Ile Ala Phe Val Ala Gly Leu Leu Ser 
                245                 250                 255     

Cys Phe Leu Ser Leu Leu Met Thr Phe Phe Val Val Val Arg Thr Leu 
            260                 265                 270         

Ile Leu Gly Asn Pro Thr Ser Gly Trp Thr Ser Leu Met Ala Val Ile 
        275                 280                 285             

Leu Phe Leu Gly Gly Ile Gln Leu Leu Thr Ile Gly Ile Leu Gly Lys 
    290                 295                 300                 

Tyr Ile Ser Lys Ile Tyr Leu Glu Thr Lys Lys Arg Pro Leu Tyr Leu 
305                 310                 315                 320 

Ile Lys Glu Lys Ser Asp Leu Pro Asp Phe Thr Glu Lys Asn Lys Val 
                325                 330                 335     

Lys Arg Leu 
            

<210>   3293
<211>   1017
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3293
atgcaagaaa agattttggt aactggtggt gccggtttta ttggaaccca cactgttatt   60
gaattgatcc aagcaggtca tcaagttgtt gtggtggata atcttgtcaa tagcaatcgt   120
aagagtttag aagttgttga aggaatcaca ggagttgaga ttcctttcta tgaggcagat   180
attcgtgaca cagataccct cagagatatt ttcaagcagg aagaaccgac tggtgtcatt   240
cactttgctg gtttgaaggc tgttggcgaa tcaacacgta tccctcttgc ctactatgac   300
aacaatatcg ctggaactgt cagccttttg aaagccatgg aagaaaacaa ctgtaaaaac   360
atcatcttca gttcttctgc gacagtttac ggggatccgc acacagtgcc catcttggaa   420
gatttcccac tttcagtgac caacccatac ggtcgtacta agctcatgct agaggaaatt   480
ttgactgata tttacaaagc agactcagaa tggaatgttg tcttgcttcg ttactttaac   540
ccaatcggag cccatgagag tggtgatttg ggagaaaatc caaacggtat tccaaacaat   600
ctcttgccat atgtgactca agtagccgtt ggaaaattag agcaagtgca agtgtttgga   660
gacgattacg atacggaaga tggaacaggt gttcgtgact atatccacgt tgtcgatttg   720
gctaagggtc acgttgcagc tttgaaaaaa atccaaaaag gttcaggact aaacgtttat   780
aaccttggaa ctggtaaagg ttactcagtt cttgaaatta tccaaaacat ggaaaaagcg   840
gtgggccgtc ctattcctta ccgcatcgta gaacgtcgcc caggtgatat cgctgcctgc   900
tactcagacc cggcaaaagc taaagcagaa ctcggttggg aagcagaact cgacatcacc   960
caaatgtgtg aagacgcatg gcgttggcaa agcaagcatc caaatggatt tgaagac      1017

<210>   3294
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-glucose 4-epimerase (galE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903503 (0.E+01)

<400>   3294
Met Gln Glu Lys Ile Leu Val Thr Gly Gly Ala Gly Phe Ile Gly Thr 
1               5                   10                  15      

His Thr Val Ile Glu Leu Ile Gln Ala Gly His Gln Val Val Val Val 
            20                  25                  30          

Asp Asn Leu Val Asn Ser Asn Arg Lys Ser Leu Glu Val Val Glu Gly 
        35                  40                  45              

Ile Thr Gly Val Glu Ile Pro Phe Tyr Glu Ala Asp Ile Arg Asp Thr 

    50                  55                  60                  

Asp Thr Leu Arg Asp Ile Phe Lys Gln Glu Glu Pro Thr Gly Val Ile 
65                  70                  75                  80  

His Phe Ala Gly Leu Lys Ala Val Gly Glu Ser Thr Arg Ile Pro Leu 
                85                  90                  95      

Ala Tyr Tyr Asp Asn Asn Ile Ala Gly Thr Val Ser Leu Leu Lys Ala 
            100                 105                 110         

Met Glu Glu Asn Asn Cys Lys Asn Ile Ile Phe Ser Ser Ser Ala Thr 
        115                 120                 125             

Val Tyr Gly Asp Pro His Thr Val Pro Ile Leu Glu Asp Phe Pro Leu 
    130                 135                 140                 

Ser Val Thr Asn Pro Tyr Gly Arg Thr Lys Leu Met Leu Glu Glu Ile 
145                 150                 155                 160 

Leu Thr Asp Ile Tyr Lys Ala Asp Ser Glu Trp Asn Val Val Leu Leu 
                165                 170                 175     

Arg Tyr Phe Asn Pro Ile Gly Ala His Glu Ser Gly Asp Leu Gly Glu 
            180                 185                 190         

Asn Pro Asn Gly Ile Pro Asn Asn Leu Leu Pro Tyr Val Thr Gln Val 
        195                 200                 205             

Ala Val Gly Lys Leu Glu Gln Val Gln Val Phe Gly Asp Asp Tyr Asp 
    210                 215                 220                 

Thr Glu Asp Gly Thr Gly Val Arg Asp Tyr Ile His Val Val Asp Leu 
225                 230                 235                 240 

Ala Lys Gly His Val Ala Ala Leu Lys Lys Ile Gln Lys Gly Ser Gly 
                245                 250                 255     

Leu Asn Val Tyr Asn Leu Gly Thr Gly Lys Gly Tyr Ser Val Leu Glu 
            260                 265                 270         

Ile Ile Gln Asn Met Glu Lys Ala Val Gly Arg Pro Ile Pro Tyr Arg 
        275                 280                 285             

Ile Val Glu Arg Arg Pro Gly Asp Ile Ala Ala Cys Tyr Ser Asp Pro 
    290                 295                 300                 

Ala Lys Ala Lys Ala Glu Leu Gly Trp Glu Ala Glu Leu Asp Ile Thr 
305                 310                 315                 320 

Gln Met Cys Glu Asp Ala Trp Arg Trp Gln Ser Lys His Pro Asn Gly 
                325                 330                 335     

Phe Glu Asp 
            

<210>   3295
<211>   147
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3295
ttgaattgga ttttcgaaga gtataagcat tttactgaaa ttttatcagg tagtttagga   60
tggcaaatga cattccctgt caaaaatggt aaaataagaa aaaataatct gagaatcgag   120
gaaaaaagat gcaagaaaag attttgg                                       147

<210>   3296
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3296
Met Asn Trp Ile Phe Glu Glu Tyr Lys His Phe Thr Glu Ile Leu Ser 
1               5                   10                  15      

Gly Ser Leu Gly Trp Gln Met Thr Phe Pro Val Lys Asn Gly Lys Ile 
            20                  25                  30          

Arg Lys Asn Asn Leu Arg Ile Glu Glu Lys Arg Cys Lys Lys Arg Phe 
        35                  40                  45              

Trp 
    

<210>   3297
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3297
gtggatagaa ctgacgaagt cagctcaaaa cactgttttg aggttgtgga tagaactgac   60
gaagtcagta accataccca tggcaaggcg acgttgacg                          99

<210>   3298
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3298
Met Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys Phe Glu Val Val 
1               5                   10                  15      

Asp Arg Thr Asp Glu Val Ser Asn His Thr His Gly Lys Ala Thr Leu 
            20                  25                  30          

Thr 
    

<210>   3299
<211>   1110
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3299
gtgaagacaa tgaaaaaagt tgccattatt ggagcaggaa ttgtgggagc aacagctgcc   60
tactacctct cgagagaaag tgacctagag gtgaccgttt ttgaccatga gcaaggtcaa   120
gccaccaagg ccgcagcagg aattatcagt ccttggtttt ccaaacgccg taataaagcc   180
tggtacaaga tggcgcgctt gggggctgat ttttatgtgg atttattagc tgatttagag   240
aaatcaggac aagaaatcga cttttaccag cgttcgggag tctttctctt gaaaaaggat   300
gaatccaatt tggaagaact ttatcaactg gccctccagc gcagagaaga atctcccttg   360
atagggcaat tagccattct gaaccaagcc tcagctaatg aattattccc tggtttgcag   420
ggatttgacc gcctgctcta tgcttctggt ggagcgagag tagatggcca acttttagtg   480
actcgtttgc tggaagtcag tcatgtcaag ctggtcaaag aaaaagtgac tctgacaccg   540
ttagcatcag gctaccagat tggtgaagag gagtttgagc aggttatttt ggcgacggga   600
gcttggttgg gggacatgtt agagccttta ggttatgaag tggatgtccg tcctcaaaaa   660
ggacaactac gagattatca gcttgcccaa gacatggaag attaccctgt tgtcatgcca   720
gaaggggagt gggatttgat tccctttgca ggtgggaaat tatccttagg cgctacccac   780
gaaaatgaca tgggatttga tttgacggta gatgaaacct tgctccaaca aatggaggag   840
gccaccttga ctcactatct gattttggct gaagctactt caaaatctga gcgtgttgga   900
atccgtgcct acaccagtga tttctctcct ttctttgggc aggtgcctga cttaactggt   960
gtctatgcag ccagtggact aggttcatca ggcctcacaa ctggtcctat cattggttac   1020
catctagccc aactgatcca agacaaggag ttgaccttgg accctctaaa ttacccaatt   1080
gaaaactatg tcaaacgagt aaaaagcgaa                                    1110

<210>   3300
<211>   370
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, DadA family protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903504 (0.E+01)

<400>   3300
Met Lys Thr Met Lys Lys Val Ala Ile Ile Gly Ala Gly Ile Val Gly 
1               5                   10                  15      

Ala Thr Ala Ala Tyr Tyr Leu Ser Arg Glu Ser Asp Leu Glu Val Thr 
            20                  25                  30          

Val Phe Asp His Glu Gln Gly Gln Ala Thr Lys Ala Ala Ala Gly Ile 
        35                  40                  45              

Ile Ser Pro Trp Phe Ser Lys Arg Arg Asn Lys Ala Trp Tyr Lys Met 
    50                  55                  60                  

Ala Arg Leu Gly Ala Asp Phe Tyr Val Asp Leu Leu Ala Asp Leu Glu 
65                  70                  75                  80  

Lys Ser Gly Gln Glu Ile Asp Phe Tyr Gln Arg Ser Gly Val Phe Leu 
                85                  90                  95      

Leu Lys Lys Asp Glu Ser Asn Leu Glu Glu Leu Tyr Gln Leu Ala Leu 
            100                 105                 110         

Gln Arg Arg Glu Glu Ser Pro Leu Ile Gly Gln Leu Ala Ile Leu Asn 
        115                 120                 125             

Gln Ala Ser Ala Asn Glu Leu Phe Pro Gly Leu Gln Gly Phe Asp Arg 
    130                 135                 140                 

Leu Leu Tyr Ala Ser Gly Gly Ala Arg Val Asp Gly Gln Leu Leu Val 
145                 150                 155                 160 

Thr Arg Leu Leu Glu Val Ser His Val Lys Leu Val Lys Glu Lys Val 
                165                 170                 175     

Thr Leu Thr Pro Leu Ala Ser Gly Tyr Gln Ile Gly Glu Glu Glu Phe 
            180                 185                 190         

Glu Gln Val Ile Leu Ala Thr Gly Ala Trp Leu Gly Asp Met Leu Glu 
        195                 200                 205             

Pro Leu Gly Tyr Glu Val Asp Val Arg Pro Gln Lys Gly Gln Leu Arg 
    210                 215                 220                 

Asp Tyr Gln Leu Ala Gln Asp Met Glu Asp Tyr Pro Val Val Met Pro 
225                 230                 235                 240 

Glu Gly Glu Trp Asp Leu Ile Pro Phe Ala Gly Gly Lys Leu Ser Leu 
                245                 250                 255     

Gly Ala Thr His Glu Asn Asp Met Gly Phe Asp Leu Thr Val Asp Glu 
            260                 265                 270         

Thr Leu Leu Gln Gln Met Glu Glu Ala Thr Leu Thr His Tyr Leu Ile 
        275                 280                 285             

Leu Ala Glu Ala Thr Ser Lys Ser Glu Arg Val Gly Ile Arg Ala Tyr 
    290                 295                 300                 

Thr Ser Asp Phe Ser Pro Phe Phe Gly Gln Val Pro Asp Leu Thr Gly 
305                 310                 315                 320 

Val Tyr Ala Ala Ser Gly Leu Gly Ser Ser Gly Leu Thr Thr Gly Pro 
                325                 330                 335     

Ile Ile Gly Tyr His Leu Ala Gln Leu Ile Gln Asp Lys Glu Leu Thr 
            340                 345                 350         

Leu Asp Pro Leu Asn Tyr Pro Ile Glu Asn Tyr Val Lys Arg Val Lys 
        355                 360                 365             

Ser Glu 
    370 

<210>   3301
<211>   795
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3301
atgttagcaa gtgaagtgat ccaagcttat gaagcctttt gccctcagga attttctatg   60
gagggagaca gccgtggtct gcaaattggc actttagaca agggtatcca aagggtcatg   120
gttgccctcg atattcgtga agagacagtg gcagaggcca ttgaaaaggg tgtggacttg   180
attatcgtca agcacgcgcc tatctttcgt cctatcaagg acttgcttgc cagccgtccg   240
caaaatcaga tttacatcga cctgattaag catgatatcg cagtttatgt cagccatacc   300
aatattgata tcgttgaaaa tgggctcaat gactggtttt gtcagatgct aggaatcgag   360
gagacgactt atctgcagga aacaggtcca gaacgtggaa ttggacgtat tgggaatatt   420
cagcctcaga cattttggga attggcccaa caggtcaagc aagtctttga cctagatagc   480
cttcgaatgg tgcattatca agaggatgat ttgcagaagc ctatttcaag agtagcaatt   540
tgtggtggaa gcgggcagtc tttctataag gatgctttgg caaagggggc agatgtctat   600
atcactggtg atatctacta ccatactgct caggatatgc tatctgatgg gttgcttgca   660
ttggacccag gtcactatat cgaagtgatt tttgtagaaa aaatcgcagc acttcttagt   720
caatggaagg aagataaggg gtggtctatt gatatcttgc ctagtcaggc atcaaccaat   780
cctttccatc atatc                                                    795

<210>   3302
<211>   265
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903505 (e-149)

<400>   3302
Met Leu Ala Ser Glu Val Ile Gln Ala Tyr Glu Ala Phe Cys Pro Gln 
1               5                   10                  15      

Glu Phe Ser Met Glu Gly Asp Ser Arg Gly Leu Gln Ile Gly Thr Leu 
            20                  25                  30          

Asp Lys Gly Ile Gln Arg Val Met Val Ala Leu Asp Ile Arg Glu Glu 
        35                  40                  45              

Thr Val Ala Glu Ala Ile Glu Lys Gly Val Asp Leu Ile Ile Val Lys 
    50                  55                  60                  

His Ala Pro Ile Phe Arg Pro Ile Lys Asp Leu Leu Ala Ser Arg Pro 
65                  70                  75                  80  

Gln Asn Gln Ile Tyr Ile Asp Leu Ile Lys His Asp Ile Ala Val Tyr 
                85                  90                  95      

Val Ser His Thr Asn Ile Asp Ile Val Glu Asn Gly Leu Asn Asp Trp 
            100                 105                 110         

Phe Cys Gln Met Leu Gly Ile Glu Glu Thr Thr Tyr Leu Gln Glu Thr 
        115                 120                 125             

Gly Pro Glu Arg Gly Ile Gly Arg Ile Gly Asn Ile Gln Pro Gln Thr 
    130                 135                 140                 

Phe Trp Glu Leu Ala Gln Gln Val Lys Gln Val Phe Asp Leu Asp Ser 
145                 150                 155                 160 

Leu Arg Met Val His Tyr Gln Glu Asp Asp Leu Gln Lys Pro Ile Ser 
                165                 170                 175     

Arg Val Ala Ile Cys Gly Gly Ser Gly Gln Ser Phe Tyr Lys Asp Ala 
            180                 185                 190         

Leu Ala Lys Gly Ala Asp Val Tyr Ile Thr Gly Asp Ile Tyr Tyr His 
        195                 200                 205             

Thr Ala Gln Asp Met Leu Ser Asp Gly Leu Leu Ala Leu Asp Pro Gly 
    210                 215                 220                 

His Tyr Ile Glu Val Ile Phe Val Glu Lys Ile Ala Ala Leu Leu Ser 
225                 230                 235                 240 

Gln Trp Lys Glu Asp Lys Gly Trp Ser Ile Asp Ile Leu Pro Ser Gln 
                245                 250                 255     

Ala Ser Thr Asn Pro Phe His His Ile 
            260                 265 

<210>   3303
<211>   675
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3303
atgatttcaa agagattaga attggtagct tcctttgtgt cacagggggc tattttacta   60
gatgtgggaa gtgaccatgc ttatctgcct atcgagttgg ttgagagagg ccaaatcaaa   120
agcgctattg caggtgaggt ggtggaaggt ccctatcagt ctgcggttaa aaatgttgag   180
gctcacggcc taaaggagaa aatccaagtc cgtttagcca atggcttggc agcttttgaa   240
gagactgacc aagtgtctgt cattaccatt gctggcatgg gtggtcgttt gattgctagg   300
attttagaag aaggtttggg gaagttagct aatgtagagc gtttgatcct ccagcccaat   360
aatcgtgaag acgacttgcg tatctggcta caggatcatg gattccagat tgtagcagaa   420
agcatcttag aagaagctgg aaagttttat gagattttgg tggtggaagc aggacaaatg   480
aagctatcag ccagtgatgt tcgctttggt cccttcttgt ccaaagaagt cagtccagta   540
tttgtccaaa aatggcaaaa agaagctgag aagctagagt tcgccctcgg acaaatccca   600
gaaaaaaatc tggaagaacg tcaagttcta gtagataaga ttcaagctat caaggaggtg   660
ctccatgtta gcaag                                                    675

<210>   3304
<211>   225
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Bcl-2 family protein
<223>   Similar to strain R6 sequence 15903506 (e-122)

<400>   3304
Met Ile Ser Lys Arg Leu Glu Leu Val Ala Ser Phe Val Ser Gln Gly 
1               5                   10                  15      

Ala Ile Leu Leu Asp Val Gly Ser Asp His Ala Tyr Leu Pro Ile Glu 
            20                  25                  30          

Leu Val Glu Arg Gly Gln Ile Lys Ser Ala Ile Ala Gly Glu Val Val 
        35                  40                  45              

Glu Gly Pro Tyr Gln Ser Ala Val Lys Asn Val Glu Ala His Gly Leu 
    50                  55                  60                  

Lys Glu Lys Ile Gln Val Arg Leu Ala Asn Gly Leu Ala Ala Phe Glu 
65                  70                  75                  80  

Glu Thr Asp Gln Val Ser Val Ile Thr Ile Ala Gly Met Gly Gly Arg 
                85                  90                  95      

Leu Ile Ala Arg Ile Leu Glu Glu Gly Leu Gly Lys Leu Ala Asn Val 
            100                 105                 110         

Glu Arg Leu Ile Leu Gln Pro Asn Asn Arg Glu Asp Asp Leu Arg Ile 
        115                 120                 125             

Trp Leu Gln Asp His Gly Phe Gln Ile Val Ala Glu Ser Ile Leu Glu 
    130                 135                 140                 

Glu Ala Gly Lys Phe Tyr Glu Ile Leu Val Val Glu Ala Gly Gln Met 
145                 150                 155                 160 

Lys Leu Ser Ala Ser Asp Val Arg Phe Gly Pro Phe Leu Ser Lys Glu 
                165                 170                 175     

Val Ser Pro Val Phe Val Gln Lys Trp Gln Lys Glu Ala Glu Lys Leu 
            180                 185                 190         

Glu Phe Ala Leu Gly Gln Ile Pro Glu Lys Asn Leu Glu Glu Arg Gln 
        195                 200                 205             

Val Leu Val Asp Lys Ile Gln Ala Ile Lys Glu Val Leu His Val Ser 
    210                 215                 220                 

Lys 
225 

<210>   3305
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3305
atggaacaaa cattgtttga attagaacta cttccagagg aagatatcat tgtcacaggt   60
ctccctaagt attgttcttt tacttgttta attacaggtc gc                      102

<210>   3306
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3306
Met Glu Gln Thr Leu Phe Glu Leu Glu Leu Leu Pro Glu Glu Asp Ile 
1               5                   10                  15      

Ile Val Thr Gly Leu Pro Lys Tyr Cys Ser Phe Thr Cys Leu Ile Thr 
            20                  25                  30          

Gly Arg 
        

<210>   3307
<211>   990
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3307
atggatttat tagagaaaga atgtttaaaa tgtgataaaa atttccaaca gggtgatatt   60
tggaattact attatttatc agataagatg cctgcacaag ggtggaaaat acacataagc   120
tcccaaataa aagacgctgt aaatattttt aagattgtgt ataaactatc ccaactaaat   180
aattgtagct ttaaagttgt taaaaattta gaggaattaa aaaaaattaa ttcccctagg   240
gaaatgagcc ctactgctaa caaatttata actctatatc ctaagtcaga atctgaagct   300
aagagtatga tttgtaatct tacgaataga ctgtcagaat ttaaggctcc aaaaatacta   360
tctgactatc aatgtggaat gcattctcca gttcattata gatatggggc ttttttaaaa   420
aaacaagctt atgatgaaaa aaataaaaaa gtcatctatt tattgctaga tgaaaaaagg   480
aagaactatg tagaagataa gagacaaaat ttccctagtc ttcctagctg gaaaatggat   540
ttattttcag aagaagaaaa aaggatttat tttcaaacca catgtgaagt ttcaagtaag   600
gactctgcaa taaataaata caaaatggaa aaaattatta agagatcaaa taaaggaaat   660
gtttatcggg caattagaaa atcggacggg caaaaagtaa tcatcaagca gtcaagacct   720
tttgtgaatt atgatgctga aggagaatgg acagctcttg atgatataaa aaatgaagct   780
cacatgctaa aaaaattagc cgataaaagt tatactacta atttaactga tgaattttat   840
atcgtggatg attattttct tgttcaggaa caagttgacg ggttaaactt tgaagaattt   900
attcgagaaa cagaacactc cttaaatatt agagaaaaaa cactggataa cattgtgaat   960
atagtaagtt acatccataa actgggaata                                    990

<210>   3308
<211>   330
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903248 (1.E-22)

<400>   3308
Met Asp Leu Leu Glu Lys Glu Cys Leu Lys Cys Asp Lys Asn Phe Gln 
1               5                   10                  15      

Gln Gly Asp Ile Trp Asn Tyr Tyr Tyr Leu Ser Asp Lys Met Pro Ala 
            20                  25                  30          

Gln Gly Trp Lys Ile His Ile Ser Ser Gln Ile Lys Asp Ala Val Asn 
        35                  40                  45              

Ile Phe Lys Ile Val Tyr Lys Leu Ser Gln Leu Asn Asn Cys Ser Phe 
    50                  55                  60                  

Lys Val Val Lys Asn Leu Glu Glu Leu Lys Lys Ile Asn Ser Pro Arg 
65                  70                  75                  80  

Glu Met Ser Pro Thr Ala Asn Lys Phe Ile Thr Leu Tyr Pro Lys Ser 
                85                  90                  95      

Glu Ser Glu Ala Lys Ser Met Ile Cys Asn Leu Thr Asn Arg Leu Ser 
            100                 105                 110         

Glu Phe Lys Ala Pro Lys Ile Leu Ser Asp Tyr Gln Cys Gly Met His 
        115                 120                 125             

Ser Pro Val His Tyr Arg Tyr Gly Ala Phe Leu Lys Lys Gln Ala Tyr 
    130                 135                 140                 

Asp Glu Lys Asn Lys Lys Val Ile Tyr Leu Leu Leu Asp Glu Lys Arg 
145                 150                 155                 160 

Lys Asn Tyr Val Glu Asp Lys Arg Gln Asn Phe Pro Ser Leu Pro Ser 
                165                 170                 175     

Trp Lys Met Asp Leu Phe Ser Glu Glu Glu Lys Arg Ile Tyr Phe Gln 
            180                 185                 190         

Thr Thr Cys Glu Val Ser Ser Lys Asp Ser Ala Ile Asn Lys Tyr Lys 
        195                 200                 205             

Met Glu Lys Ile Ile Lys Arg Ser Asn Lys Gly Asn Val Tyr Arg Ala 
    210                 215                 220                 

Ile Arg Lys Ser Asp Gly Gln Lys Val Ile Ile Lys Gln Ser Arg Pro 
225                 230                 235                 240 

Phe Val Asn Tyr Asp Ala Glu Gly Glu Trp Thr Ala Leu Asp Asp Ile 
                245                 250                 255     

Lys Asn Glu Ala His Met Leu Lys Lys Leu Ala Asp Lys Ser Tyr Thr 
            260                 265                 270         

Thr Asn Leu Thr Asp Glu Phe Tyr Ile Val Asp Asp Tyr Phe Leu Val 
        275                 280                 285             

Gln Glu Gln Val Asp Gly Leu Asn Phe Glu Glu Phe Ile Arg Glu Thr 
    290                 295                 300                 

Glu His Ser Leu Asn Ile Arg Glu Lys Thr Leu Asp Asn Ile Val Asn 
305                 310                 315                 320 

Ile Val Ser Tyr Ile His Lys Leu Gly Ile 
                325                 330 

<210>   3309
<211>   339
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3309
atgttggaac aggcattcaa agagaagcac tatgagaata cgattctcca tagtgaccaa   60
ggctggcaat accaacacga ttcttatcat cggttcctag agagtaaggg aattcaagca   120
tccatgtcac gcaagggcaa cagcccagac aacggcatga tggaatcttt ctttggcatt   180
ttgaaatcgg agatgtttta tggttatgag aagaacttta gatctttaga aaaccttgaa   240
caagctattg tggactacat tgattattac aacaacaaga gaattaaggt aaagctaaaa   300
ggacttagcc ctgtgcaata cagaactaaa tccttcgga                          339

<210>   3310
<211>   113
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA transposase

<400>   3310
Met Leu Glu Gln Ala Phe Lys Glu Lys His Tyr Glu Asn Thr Ile Leu 
1               5                   10                  15      

His Ser Asp Gln Gly Trp Gln Tyr Gln His Asp Ser Tyr His Arg Phe 
            20                  25                  30          

Leu Glu Ser Lys Gly Ile Gln Ala Ser Met Ser Arg Lys Gly Asn Ser 
        35                  40                  45              

Pro Asp Asn Gly Met Met Glu Ser Phe Phe Gly Ile Leu Lys Ser Glu 
    50                  55                  60                  

Met Phe Tyr Gly Tyr Glu Lys Asn Phe Arg Ser Leu Glu Asn Leu Glu 
65                  70                  75                  80  

Gln Ala Ile Val Asp Tyr Ile Asp Tyr Tyr Asn Asn Lys Arg Ile Lys 
                85                  90                  95      

Val Lys Leu Lys Gly Leu Ser Pro Val Gln Tyr Arg Thr Lys Ser Phe 
            100                 105                 110         

Gly 
    

<210>   3311
<211>   831
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3311
atgactgagt tttcgttaga tcttcttcta aaagccatta aactagctcg ttggacctac   60
tactatcact tgaaacagct agataaacca gataaggacc aagagcttaa agctgaaatt   120
caatccatct ttatcgaaca caagggaaat tatgcttatc gccgggttca tttagaacta   180
agaaatcgtg cttatctggt aaatcataaa agagttcaag gcttgatgaa agtactcaat   240
ttacaagcta aaatgcgaca gaaacgaaaa tattcttctc ataaaggaga cgttggtaag   300
aaagcagaga atctcattca aggccaattt gaaggctcta aaacaatgga aaagtgctac   360
acagatgtga cagaatttgc cattccagca agtactcaaa aactttactt atcaccagtt   420
ttagatggct ttaacagcga aattattgct tttaatcttt cttgttcgcc taatttagaa   480
taagtacaaa caatgttgga acaggcattc aaagagaagc actatgagaa tacgattctc   540
catagtgacc aaggctggca ataccaacac gattcttatc atcggttcct agagagtaag   600
ggaattcaag catccatgtc acgcaagggc aacagcccag acaacggcat gatggaatct   660
ttctttggca ttttgaaatc ggagatgttt tatggttatg agaagaactt tagatcttta   720
gaaaaccttg aacaagctat tgtggactac attgattatt acaacaacaa gagaattaag   780
gtaaagctaa aaggacttag ccctgtgcaa tacagaacta aatccttcgg a            831

<210>   3312
<211>   160
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, transposase POINT MUTATION

<400>   3312
Met Thr Glu Phe Ser Leu Asp Leu Leu Leu Lys Ala Ile Lys Leu Ala 
1               5                   10                  15      

Arg Trp Thr Tyr Tyr Tyr His Leu Lys Gln Leu Asp Lys Pro Asp Lys 
            20                  25                  30          

Asp Gln Glu Leu Lys Ala Glu Ile Gln Ser Ile Phe Ile Glu His Lys 
        35                  40                  45              

Gly Asn Tyr Ala Tyr Arg Arg Val His Leu Glu Leu Arg Asn Arg Ala 
    50                  55                  60                  

Tyr Leu Val Asn His Lys Arg Val Gln Gly Leu Met Lys Val Leu Asn 
65                  70                  75                  80  

Leu Gln Ala Lys Met Arg Gln Lys Arg Lys Tyr Ser Ser His Lys Gly 
                85                  90                  95      

Asp Val Gly Lys Lys Ala Glu Asn Leu Ile Gln Gly Gln Phe Glu Gly 
            100                 105                 110         

Ser Lys Thr Met Glu Lys Cys Tyr Thr Asp Val Thr Glu Phe Ala Ile 
        115                 120                 125             

Pro Ala Ser Thr Gln Lys Leu Tyr Leu Ser Pro Val Leu Asp Gly Phe 
    130                 135                 140                 

Asn Ser Glu Ile Ile Ala Phe Asn Leu Ser Cys Ser Pro Asn Leu Glu 
145                 150                 155                 160 


<210>   3313
<211>   436
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3313
atgaaattaa cttatgatga taaagttcag ttctatgaac ttagaaaaca aggatatatc   60
ttagagaagc tttcaaataa atttgggata aataattcta atcttaggta catgattaaa   120
ttgattgatc gttacggaat agagttcgtc aaaaaaggga aaaatcgtta ctattctcct   180
gatttaaaac aagaaatgat tcataaagtc tgacatgaag gctggactaa agatagagtt   240
tctcttgaat acggtctccc aagtcgtacg atacttctta actggctagc acaatacagg   300
aaaaacgggt atactattgt tgagaaaaca aaagggagag tacctgagag cggagaatgc   360
catcctaaaa aagttaagag aactccgatt gaaggaggaa aaagagaaat aagaaagaca   420
gaaattgttc aagaat                                                   436

<210>   3314
<211>   70
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, hypothetical protein POINT MUTATION FRAMESHIFT

<400>   3314
Met Lys Leu Thr Tyr Asp Asp Lys Val Gln Phe Tyr Glu Leu Arg Lys 
1               5                   10                  15      

Gln Gly Tyr Ile Leu Glu Lys Leu Ser Asn Lys Phe Gly Ile Asn Asn 
            20                  25                  30          

Ser Asn Leu Arg Tyr Met Ile Lys Leu Ile Asp Arg Tyr Gly Ile Glu 
        35                  40                  45              

Phe Val Lys Lys Gly Lys Asn Arg Tyr Tyr Ser Pro Asp Leu Lys Gln 
    50                  55                  60                  

Glu Met Ile His Lys Val 
65                  70  

<210>   3315
<211>   1965
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3315
atgtcactac aatcagttaa cgccattcgt tttcttggcg tagatgctat taacaaatct   60
aattctggtc acccgggaat tgtcatgggt gctgcgccaa tggcttatag cctatttaca   120
aagcacctta gaattacacc tgagcagcca aactggatta accgagatcg ctttatcttg   180
tctgcgggtc atggatcaat gctactgtat gctctcttgc atttaacagg gtataaggat   240
gtatccatgg acgagattaa aaatttccgg caatggggat ctaagacacc tggtcatcct   300
gaagtgacgc atacgtctgg tgtggatgcg acatctggtc cgcttggtca ggggatttct   360
actgccgttg gtttcgccca agcagagcgt tttttagctg ctaagtacaa caaagatggt   420
ttccctattt ttgaccatta tacttatgtt atcgctggag acggtgactt catggaagga   480
gtgtctgcgg aggcggcttc ttatgcaggt catcaagctt tagataagct tatcgtcctc   540
tacgactcca acgacatctg cttggatggt gagaccaaag atactttctc tgaaaatgtt   600
cgcgtccgtt acgatgctta tggttggcat acagttctgg tagaagatgg aacagattta   660
gcagcaattt ctacagcaat tgagacggcc aagttttctg gtaaaccgag tttgattgaa   720
gtgaaaacgg taattggtta cggctcaccc aataaaagtg gtacaaatgc tgttcatggt   780
gcaccactag gagcagaaga aacaggagca actcgtaagt ttttgggatg ggattacgat   840
ccatttgaag taccagagga agtatattct gatttcaaga caaatgtagc ggatcgtggt   900
caggaggcat acgatgcttg ggctagtttg gtgtctgatt acaaggttgc ttatcccgaa   960
gttgctagtg agattgacgc tattgtagct ggaaaatccc ctgtaaccat tactgaaaaa   1020
gacttccctg tctatgagaa tggcttctct caagcaactc gtaattcgtc ccaagatgct   1080
attaatacag cagcagtttt accaaccttc ttaggtggat cggcagactt agctcactct   1140
aacatgacct acatcaaggc agatggctta caagataaat ataatccatt aaaccgcaat   1200
attcagtttg gggtacgtga atttgccatg ggaacaatcc tcaatggaat ggctcttcat   1260
ggtggtttac gagtttatgg cggaaccttc tttgttttct ctgactacgt caaagctgct   1320
attcggctat cagccattca ggagttgcct gtaacttatg tctttaccca tgattcaatt   1380
gccgttggtg aagatggtcc aactcatgaa ccagttgaac atttggcagg tttacgctca   1440
atgccaaact tgactgttat ccgtccagcg gatgcccgtg aaactcaagc ggcttggcat   1500
catgccttga ccagtaccac cactccaact gtcattgtct taacccgtca aaacttggta   1560
gttgaagaag ggacagactt tggtaaggtc gctaaaggag cctacgtcgt gtatgatacc   1620
ccgggatttg atactattat cattgctaca ggatctgagg tcaatctagc tatcaaagct   1680
gctaaggaat tggttttaca aggtggtaaa gtacgtgtgg tatctatgcc ctcaaccgaa   1740
ctatttgatg ctcaagatgc tacctacaag gaagacattt taccatctaa gactcgtcgt   1800
cgtgtggcca ttgaaatggc agcgacccaa agttggtaca agtatgttgg tttggatggc   1860
gcggtcatcg gtattgacat cttcggtgcg tctgccccag ctcagactgt gattgataat   1920
tatggattta cggtagagaa tatcgttgct caagttaagt cccta                   1965

<210>   3316
<211>   655
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transketolase, FRAMESHIFT (recP)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903883 (0.E+01)

<400>   3316
Met Ser Leu Gln Ser Val Asn Ala Ile Arg Phe Leu Gly Val Asp Ala 
1               5                   10                  15      

Ile Asn Lys Ser Asn Ser Gly His Pro Gly Ile Val Met Gly Ala Ala 
            20                  25                  30          

Pro Met Ala Tyr Ser Leu Phe Thr Lys His Leu Arg Ile Thr Pro Glu 
        35                  40                  45              

Gln Pro Asn Trp Ile Asn Arg Asp Arg Phe Ile Leu Ser Ala Gly His 
    50                  55                  60                  

Gly Ser Met Leu Leu Tyr Ala Leu Leu His Leu Thr Gly Tyr Lys Asp 
65                  70                  75                  80  

Val Ser Met Asp Glu Ile Lys Asn Phe Arg Gln Trp Gly Ser Lys Thr 
                85                  90                  95      

Pro Gly His Pro Glu Val Thr His Thr Ser Gly Val Asp Ala Thr Ser 
            100                 105                 110         

Gly Pro Leu Gly Gln Gly Ile Ser Thr Ala Val Gly Phe Ala Gln Ala 
        115                 120                 125             

Glu Arg Phe Leu Ala Ala Lys Tyr Asn Lys Asp Gly Phe Pro Ile Phe 
    130                 135                 140                 

Asp His Tyr Thr Tyr Val Ile Ala Gly Asp Gly Asp Phe Met Glu Gly 
145                 150                 155                 160 

Val Ser Ala Glu Ala Ala Ser Tyr Ala Gly His Gln Ala Leu Asp Lys 
                165                 170                 175     

Leu Ile Val Leu Tyr Asp Ser Asn Asp Ile Cys Leu Asp Gly Glu Thr 
            180                 185                 190         

Lys Asp Thr Phe Ser Glu Asn Val Arg Val Arg Tyr Asp Ala Tyr Gly 
        195                 200                 205             

Trp His Thr Val Leu Val Glu Asp Gly Thr Asp Leu Ala Ala Ile Ser 
    210                 215                 220                 

Thr Ala Ile Glu Thr Ala Lys Phe Ser Gly Lys Pro Ser Leu Ile Glu 
225                 230                 235                 240 

Val Lys Thr Val Ile Gly Tyr Gly Ser Pro Asn Lys Ser Gly Thr Asn 
                245                 250                 255     

Ala Val His Gly Ala Pro Leu Gly Ala Glu Glu Thr Gly Ala Thr Arg 
            260                 265                 270         

Lys Phe Leu Gly Trp Asp Tyr Asp Pro Phe Glu Val Pro Glu Glu Val 
        275                 280                 285             

Tyr Ser Asp Phe Lys Thr Asn Val Ala Asp Arg Gly Gln Glu Ala Tyr 
    290                 295                 300                 

Asp Ala Trp Ala Ser Leu Val Ser Asp Tyr Lys Val Ala Tyr Pro Glu 
305                 310                 315                 320 

Val Ala Ser Glu Ile Asp Ala Ile Val Ala Gly Lys Ser Pro Val Thr 
                325                 330                 335     

Ile Thr Glu Lys Asp Phe Pro Val Tyr Glu Asn Gly Phe Ser Gln Ala 
            340                 345                 350         

Thr Arg Asn Ser Ser Gln Asp Ala Ile Asn Thr Ala Ala Val Leu Pro 
        355                 360                 365             

Thr Phe Leu Gly Gly Ser Ala Asp Leu Ala His Ser Asn Met Thr Tyr 
    370                 375                 380                 

Ile Lys Ala Asp Gly Leu Gln Asp Lys Tyr Asn Pro Leu Asn Arg Asn 
385                 390                 395                 400 

Ile Gln Phe Gly Val Arg Glu Phe Ala Met Gly Thr Ile Leu Asn Gly 
                405                 410                 415     

Met Ala Leu His Gly Gly Leu Arg Val Tyr Gly Gly Thr Phe Phe Val 
            420                 425                 430         

Phe Ser Asp Tyr Val Lys Ala Ala Ile Arg Leu Ser Ala Ile Gln Glu 
        435                 440                 445             

Leu Pro Val Thr Tyr Val Phe Thr His Asp Ser Ile Ala Val Gly Glu 
    450                 455                 460                 

Asp Gly Pro Thr His Glu Pro Val Glu His Leu Ala Gly Leu Arg Ser 
465                 470                 475                 480 

Met Pro Asn Leu Thr Val Ile Arg Pro Ala Asp Ala Arg Glu Thr Gln 
                485                 490                 495     

Ala Ala Trp His His Ala Leu Thr Ser Thr Thr Thr Pro Thr Val Ile 
            500                 505                 510         


Val Leu Thr Arg Gln Asn Leu Val Val Glu Glu Gly Thr Asp Phe Gly 
        515                 520                 525             

Lys Val Ala Lys Gly Ala Tyr Val Val Tyr Asp Thr Pro Gly Phe Asp 
    530                 535                 540                 

Thr Ile Ile Ile Ala Thr Gly Ser Glu Val Asn Leu Ala Ile Lys Ala 
545                 550                 555                 560 

Ala Lys Glu Leu Val Leu Gln Gly Gly Lys Val Arg Val Val Ser Met 
                565                 570                 575     

Pro Ser Thr Glu Leu Phe Asp Ala Gln Asp Ala Thr Tyr Lys Glu Asp 
            580                 585                 590         

Ile Leu Pro Ser Lys Thr Arg Arg Arg Val Ala Ile Glu Met Ala Ala 
        595                 600                 605             

Thr Gln Ser Trp Tyr Lys Tyr Val Gly Leu Asp Gly Ala Val Ile Gly 
    610                 615                 620                 

Ile Asp Ile Phe Gly Ala Ser Ala Pro Ala Gln Thr Val Ile Asp Asn 
625                 630                 635                 640 

Tyr Gly Phe Thr Val Glu Asn Ile Val Ala Gln Val Lys Ser Leu 
                645                 650                 655 

<210>   3317
<211>   744
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3317
ttgaagaaga gattgatttg tcagatattg aaattttgta agagggtaac gatgtcaaga   60
attgaatttt caccatcttt gatgaccatg gatttggaca aattcaaaga gcagattact   120
tttttgaatg ataaagtagc atcttatcat atcgatatta tggatggcca ttttgttccc   180
aatattacct tgtctccttg gttcattcaa gaagttcaaa aaattagtga cacaccttta   240
tcagttcatc tgatggtcac agacccaacc ttttgggtag atcaagttct cgatttacaa   300
tgtgagtata tttgtattca tgctgaagtt ctgaatggtc ttgcttttcg tttgattgat   360
aaaattcatg atgcaggtct aaaggctggt gttgtcctta atcctgaaac acctgtttct   420
acaatctttc cctacattga tttacttgac aaagcaacta ttatgactgt agatccaggt   480
tttgcaggac aacgcttttt ggagtctacc ttgtataaaa tccaagaact ccgtcagctt   540
agagttcaga atggttatca ctacatcatt gagatggatg gttcttcgag tcgtaagact   600
ttcaaacaaa ttgatgtggc aggaccagat atttatgtta taggtcgcag tggattattt   660
ggtttggatg acgatattgc caaagcctgg gatatctgtt ctagagatta cgaagaaatg   720
accggaaaaa caatgccaat caaa                                          744

<210>   3318
<211>   248
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribulose-phosphate 3-epimerase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903839 (1.E-31)

<400>   3318
Met Lys Lys Arg Leu Ile Cys Gln Ile Leu Lys Phe Cys Lys Arg Val 
1               5                   10                  15      

Thr Met Ser Arg Ile Glu Phe Ser Pro Ser Leu Met Thr Met Asp Leu 
            20                  25                  30          

Asp Lys Phe Lys Glu Gln Ile Thr Phe Leu Asn Asp Lys Val Ala Ser 
        35                  40                  45              

Tyr His Ile Asp Ile Met Asp Gly His Phe Val Pro Asn Ile Thr Leu 
    50                  55                  60                  

Ser Pro Trp Phe Ile Gln Glu Val Gln Lys Ile Ser Asp Thr Pro Leu 
65                  70                  75                  80  

Ser Val His Leu Met Val Thr Asp Pro Thr Phe Trp Val Asp Gln Val 
                85                  90                  95      

Leu Asp Leu Gln Cys Glu Tyr Ile Cys Ile His Ala Glu Val Leu Asn 
            100                 105                 110         

Gly Leu Ala Phe Arg Leu Ile Asp Lys Ile His Asp Ala Gly Leu Lys 
        115                 120                 125             

Ala Gly Val Val Leu Asn Pro Glu Thr Pro Val Ser Thr Ile Phe Pro 
    130                 135                 140                 

Tyr Ile Asp Leu Leu Asp Lys Ala Thr Ile Met Thr Val Asp Pro Gly 
145                 150                 155                 160 

Phe Ala Gly Gln Arg Phe Leu Glu Ser Thr Leu Tyr Lys Ile Gln Glu 
                165                 170                 175     

Leu Arg Gln Leu Arg Val Gln Asn Gly Tyr His Tyr Ile Ile Glu Met 
            180                 185                 190         

Asp Gly Ser Ser Ser Arg Lys Thr Phe Lys Gln Ile Asp Val Ala Gly 
        195                 200                 205             

Pro Asp Ile Tyr Val Ile Gly Arg Ser Gly Leu Phe Gly Leu Asp Asp 
    210                 215                 220                 

Asp Ile Ala Lys Ala Trp Asp Ile Cys Ser Arg Asp Tyr Glu Glu Met 
225                 230                 235                 240 

Thr Gly Lys Thr Met Pro Ile Lys 
                245             

<210>   3319
<211>   1083
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3319
atgttgaaac acttaaactt aaaaggtcac ttattgacag ccatttccta tatgattcca   60
attgtttgtg gtgcaggatt cttagttgcc attggtttag caatgggggg tggtgttcct   120
gacgctcttg tagcaggaaa attcactatc tgggatgctt tagcaactat gggtggtaaa   180
gcccttggtc tcttgccagt tgttattgct acaggtttgt cttactcgat tgctggtaag   240
ccagggattg caccaggttt tgttgttggt ctaattgcca attctgttgg ttcagggttt   300
atcggtggta tcttgggagg ttatatagct ggtttcttgg ttcaagcgat tattaaaaag   360
gtcaaagtac caaactggat taaaggttta atgccaacct tgattattcc ttttgtagcc   420
tctttggtaa gtagtttgat tatgatttat attattggag cgcctatcgc agcctttacc   480
aactggttga cgagcttatt acaaagcttg ggaagtgctt caaatggttt gatgggggca   540
gttattggaa ttctcagtgc tgttgacttt ggtggcccac ttaataaaac agtctatgcg   600
tttgtgttga ctttacaggc tgaaggtgtg aaagaaccat tgactgcttt acaattggtg   660
aatactgcta caccagttgg atttggattg gcctatttta tcgcgaaatt actcaaaaaa   720
aatatctata ctcaagagga aatcgaaaca ttgaaatcgg ctgttcctat ggggattgtc   780
aatattgttg aaggtgtaat tccgattgtt atgaataact tggttccagg tctcattgca   840
acaggtatcg gtggtgctgt tggtggtgct gtttctttga caatgggtgc tgattctgct   900
gtgccatttg gtggagtgct tatgttacca accatgactc gtccagtagc tggtatttgt   960
gccttgttag ctaacattgt agtcacagga cttgtctacg cgattttgaa aaaaccaata   1020
aaacatgcag aaccagttat gactgttgaa gaagagattg atttgtcaga tattgaaatt   1080
ttg                                                                 1083

<210>   3320
<211>   361
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIC component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902824 (3.E-46)

<400>   3320
Met Leu Lys His Leu Asn Leu Lys Gly His Leu Leu Thr Ala Ile Ser 
1               5                   10                  15      

Tyr Met Ile Pro Ile Val Cys Gly Ala Gly Phe Leu Val Ala Ile Gly 
            20                  25                  30          

Leu Ala Met Gly Gly Gly Val Pro Asp Ala Leu Val Ala Gly Lys Phe 
        35                  40                  45              

Thr Ile Trp Asp Ala Leu Ala Thr Met Gly Gly Lys Ala Leu Gly Leu 
    50                  55                  60                  

Leu Pro Val Val Ile Ala Thr Gly Leu Ser Tyr Ser Ile Ala Gly Lys 
65                  70                  75                  80  

Pro Gly Ile Ala Pro Gly Phe Val Val Gly Leu Ile Ala Asn Ser Val 
                85                  90                  95      

Gly Ser Gly Phe Ile Gly Gly Ile Leu Gly Gly Tyr Ile Ala Gly Phe 
            100                 105                 110         

Leu Val Gln Ala Ile Ile Lys Lys Val Lys Val Pro Asn Trp Ile Lys 
        115                 120                 125             

Gly Leu Met Pro Thr Leu Ile Ile Pro Phe Val Ala Ser Leu Val Ser 
    130                 135                 140                 

Ser Leu Ile Met Ile Tyr Ile Ile Gly Ala Pro Ile Ala Ala Phe Thr 
145                 150                 155                 160 

Asn Trp Leu Thr Ser Leu Leu Gln Ser Leu Gly Ser Ala Ser Asn Gly 
                165                 170                 175     

Leu Met Gly Ala Val Ile Gly Ile Leu Ser Ala Val Asp Phe Gly Gly 
            180                 185                 190         

Pro Leu Asn Lys Thr Val Tyr Ala Phe Val Leu Thr Leu Gln Ala Glu 
        195                 200                 205             

Gly Val Lys Glu Pro Leu Thr Ala Leu Gln Leu Val Asn Thr Ala Thr 
    210                 215                 220                 

Pro Val Gly Phe Gly Leu Ala Tyr Phe Ile Ala Lys Leu Leu Lys Lys 
225                 230                 235                 240 

Asn Ile Tyr Thr Gln Glu Glu Ile Glu Thr Leu Lys Ser Ala Val Pro 
                245                 250                 255     

Met Gly Ile Val Asn Ile Val Glu Gly Val Ile Pro Ile Val Met Asn 
            260                 265                 270         

Asn Leu Val Pro Gly Leu Ile Ala Thr Gly Ile Gly Gly Ala Val Gly 
        275                 280                 285             

Gly Ala Val Ser Leu Thr Met Gly Ala Asp Ser Ala Val Pro Phe Gly 
    290                 295                 300                 

Gly Val Leu Met Leu Pro Thr Met Thr Arg Pro Val Ala Gly Ile Cys 
305                 310                 315                 320 

Ala Leu Leu Ala Asn Ile Val Val Thr Gly Leu Val Tyr Ala Ile Leu 
                325                 330                 335     

Lys Lys Pro Ile Lys His Ala Glu Pro Val Met Thr Val Glu Glu Glu 
            340                 345                 350         

Ile Asp Leu Ser Asp Ile Glu Ile Leu 
        355                 360     

<210>   3321
<211>   324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3321
ttggagggta tccgtatgaa aattgttggt gttgcagctt gtactgtggg aattgcccac   60
acttatattg cacaggaaaa attagagaat gccgcaaagg tagctggaca tgtgattcat   120
gttgagactc aggggacaat aggggtagaa aatgaattga gtcaagagca gattgatgca   180
gcggatgtag ttattttagc agttgatgtt aagatttctg gtatggaacg ctttgagggt   240
aaaaagatta tcaaggttcc aacagaagtg gcagtcaaat ctcccaataa actgattgct   300
aaagctgttg agattgttac gaaa                                          324

<210>   3322
<211>   108
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   PTS system, IIB component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902824 (1.E-16)

<400>   3322
Met Glu Gly Ile Arg Met Lys Ile Val Gly Val Ala Ala Cys Thr Val 
1               5                   10                  15      

Gly Ile Ala His Thr Tyr Ile Ala Gln Glu Lys Leu Glu Asn Ala Ala 
            20                  25                  30          

Lys Val Ala Gly His Val Ile His Val Glu Thr Gln Gly Thr Ile Gly 
        35                  40                  45              

Val Glu Asn Glu Leu Ser Gln Glu Gln Ile Asp Ala Ala Asp Val Val 
    50                  55                  60                  

Ile Leu Ala Val Asp Val Lys Ile Ser Gly Met Glu Arg Phe Glu Gly 
65                  70                  75                  80  

Lys Lys Ile Ile Lys Val Pro Thr Glu Val Ala Val Lys Ser Pro Asn 
                85                  90                  95      

Lys Leu Ile Ala Lys Ala Val Glu Ile Val Thr Lys 
            100                 105             

<210>   3323
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3323
atggaaatca aagatattct taatgtgagt ctgatccaga cggatttaca gatgcagagc   60
aaagaagagg tttttgaggc attagctcaa ctattggttg agacgggtta tgtgtctgat   120
agagaccaat ttatcgaagg tctttatcag agagaggcag aaggacagac cggtattggg   180
aattatattg ctattcccca tagcaagagt tctgctgtgg agaaggcggg ggtagtcata   240
gctataaatc acaatgagat tccttgggag accattgatg ggaaaggggt caaagtaatt   300
gtactctttg cagttggtga tgatacagaa gctgctaggg agcatttgaa gaccttatca   360
ctctttgctc gaaaacttgg taatgacgaa gttgttgcca aattagttcg ggctcagaca   420
tctgatgatg tgattgcagc tttttgt                                       447

<210>   3324
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIA component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902824 (4.E-20)

<400>   3324
Met Glu Ile Lys Asp Ile Leu Asn Val Ser Leu Ile Gln Thr Asp Leu 
1               5                   10                  15      

Gln Met Gln Ser Lys Glu Glu Val Phe Glu Ala Leu Ala Gln Leu Leu 
            20                  25                  30          

Val Glu Thr Gly Tyr Val Ser Asp Arg Asp Gln Phe Ile Glu Gly Leu 
        35                  40                  45              

Tyr Gln Arg Glu Ala Glu Gly Gln Thr Gly Ile Gly Asn Tyr Ile Ala 
    50                  55                  60                  

Ile Pro His Ser Lys Ser Ser Ala Val Glu Lys Ala Gly Val Val Ile 
65                  70                  75                  80  

Ala Ile Asn His Asn Glu Ile Pro Trp Glu Thr Ile Asp Gly Lys Gly 
                85                  90                  95      

Val Lys Val Ile Val Leu Phe Ala Val Gly Asp Asp Thr Glu Ala Ala 
            100                 105                 110         

Arg Glu His Leu Lys Thr Leu Ser Leu Phe Ala Arg Lys Leu Gly Asn 
        115                 120                 125             

Asp Glu Val Val Ala Lys Leu Val Arg Ala Gln Thr Ser Asp Asp Val 
    130                 135                 140                 

Ile Ala Ala Phe Cys 
145                 

<210>   3325
<211>   426
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3325
atgaataatc tttcgcttgt ccttatggat atatctgttc aaaatcgtca agaagcctac   60
aaagaattag caaatcaaat cagccttctt gtttctgaag atacagaaaa aatagaagag   120
cttctatatt accgtgagag acagggaagt atagaggttg ctaaaggtgt tcttctacca   180
cattgtgaag gaaactttca acatcatgtc ttagtgatta ctagattaaa atcacctatc   240
agagaatggt cgaaggatat ccagtgtgtt gaccttatta tcggtttggc cattgcagta   300
tcacaggaca agtcatgtat taaaacattg atgagaagac tagcagatga atcattcata   360
aatcaattaa aacagttaac aaaagaagaa ttacgggaga taatatatgg aaatcaaaga   420
tattct                                                              426

<210>   3326
<211>   142
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, nitrogen regulatory component IIA, putative
<223>   Cellular location: cytoplasm

<400>   3326
Met Asn Asn Leu Ser Leu Val Leu Met Asp Ile Ser Val Gln Asn Arg 
1               5                   10                  15      

Gln Glu Ala Tyr Lys Glu Leu Ala Asn Gln Ile Ser Leu Leu Val Ser 
            20                  25                  30          

Glu Asp Thr Glu Lys Ile Glu Glu Leu Leu Tyr Tyr Arg Glu Arg Gln 
        35                  40                  45              

Gly Ser Ile Glu Val Ala Lys Gly Val Leu Leu Pro His Cys Glu Gly 
    50                  55                  60                  

Asn Phe Gln His His Val Leu Val Ile Thr Arg Leu Lys Ser Pro Ile 
65                  70                  75                  80  

Arg Glu Trp Ser Lys Asp Ile Gln Cys Val Asp Leu Ile Ile Gly Leu 
                85                  90                  95      

Ala Ile Ala Val Ser Gln Asp Lys Ser Cys Ile Lys Thr Leu Met Arg 
            100                 105                 110         

Arg Leu Ala Asp Glu Ser Phe Ile Asn Gln Leu Lys Gln Leu Thr Lys 
        115                 120                 125             

Glu Glu Leu Arg Glu Ile Ile Tyr Gly Asn Gln Arg Tyr Ser 
    130                 135                 140         

<210>   3327
<211>   1461
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3327
gtgtctagaa aacaagaaca aatggaaacg ttgttgctcc ttttgcgaga tagtaaggat   60
tatatatctg ctaaagtatt gggagaaaaa ttaaattgct ctgataaaac ggtttatcgc   120
cttgtcaagg gaatcaacaa agattgtccg gtagaagcat tcattttatc tgaaaaaggc   180
agaggtttca aattaaatcc aagaagttcc ctcgtggacg ttgatgggaa ttttacagag   240
gcttttgatc ctgaagtaag gcgtgaaaaa ttactagaac gtctcttgtt gactgctcct   300
aagccacatt ctatttatga tttaggagag gaattctacg taagcgagtc agtagtacta   360
aaagatcgtc agatattaca agagagtcta gcaatttatg ggttagattt aaaaatgaga   420
caacgaaagc tttttattga tggggatgag gctcaaattc gttcagccat tctaaatcta   480
ctgccaatgt ttaatcagtt ggatttagag caaattacac agaataaggt tcagcctctt   540
gacggagaac ttgctcactt ttgtttggga ttactgatta cacttgagag agaattgggg   600
gtaaacattc cctatccata taatataaat attttctctc acctgtatat ttttatcagt   660
aggaatcgtc gtagtactag tattcatgtt gtagcacctt caaaacctac tattgttgat   720
gagaaaattt acagtgtctg tcaaaaaatt attcaagaaa ttgaacaata ttttaggatg   780
aaggttgatg cagttgagat tgactatctt tatcaatacg ttgtatcttc gagattgcaa   840
aaaccatttt cttccgggaa gcttcctttt tctcagcgag ttttagatgt cactcattac   900
tattttagcc gtatgtgtat ggacaataga gagattgaaa cgacagatcc tgactttgtt   960
gacttggcga gtcatatcag tcccttactg aggagattag ataatagagt acagattaag   1020
aatagtcttt tatcacaaat tcttttaacc tatcctaatc tggttaaaga gttaacaact   1080
atttctaaag aagtgagtct agtatttggt tttgcttcct tgagtctgga cgagattggt   1140
tttctagtct tatattttgc acggtttcaa gaaaagcgag cacgtcctct aaaaacagta   1200
gtgatgtgta catcaggtgt cggaacttca gagcttttac gagcacgatt agaaaagcaa   1260
ttttctgaat tggatattat tgatgtagtt gcttatcatc aattagatga gctgataaat   1320
ctatatccag atttagattt cattgtgacg acggtagctt tgcaggaacc agcaagtgtc   1380
ccgtttgtcc tagttagtgt ttttctaacc gagggtgata aacaacgtct tcaagcaaaa   1440
attcaggaga taaactatga a                                             1461

<210>   3328
<211>   487
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcription antiterminator BglG family protein, FRAMESHIFT
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902323 (5.E-26)

<400>   3328
Met Ser Arg Lys Gln Glu Gln Met Glu Thr Leu Leu Leu Leu Leu Arg 
1               5                   10                  15      

Asp Ser Lys Asp Tyr Ile Ser Ala Lys Val Leu Gly Glu Lys Leu Asn 
            20                  25                  30          

Cys Ser Asp Lys Thr Val Tyr Arg Leu Val Lys Gly Ile Asn Lys Asp 
        35                  40                  45              

Cys Pro Val Glu Ala Phe Ile Leu Ser Glu Lys Gly Arg Gly Phe Lys 
    50                  55                  60                  

Leu Asn Pro Arg Ser Ser Leu Val Asp Val Asp Gly Asn Phe Thr Glu 
65                  70                  75                  80  

Ala Phe Asp Pro Glu Val Arg Arg Glu Lys Leu Leu Glu Arg Leu Leu 
                85                  90                  95      

Leu Thr Ala Pro Lys Pro His Ser Ile Tyr Asp Leu Gly Glu Glu Phe 
            100                 105                 110         

Tyr Val Ser Glu Ser Val Val Leu Lys Asp Arg Gln Ile Leu Gln Glu 
        115                 120                 125             

Ser Leu Ala Ile Tyr Gly Leu Asp Leu Lys Met Arg Gln Arg Lys Leu 
    130                 135                 140                 

Phe Ile Asp Gly Asp Glu Ala Gln Ile Arg Ser Ala Ile Leu Asn Leu 
145                 150                 155                 160 

Leu Pro Met Phe Asn Gln Leu Asp Leu Glu Gln Ile Thr Gln Asn Lys 
                165                 170                 175     

Val Gln Pro Leu Asp Gly Glu Leu Ala His Phe Cys Leu Gly Leu Leu 
            180                 185                 190         

Ile Thr Leu Glu Arg Glu Leu Gly Val Asn Ile Pro Tyr Pro Tyr Asn 
        195                 200                 205             

Ile Asn Ile Phe Ser His Leu Tyr Ile Phe Ile Ser Arg Asn Arg Arg 
    210                 215                 220                 

Ser Thr Ser Ile His Val Val Ala Pro Ser Lys Pro Thr Ile Val Asp 
225                 230                 235                 240 

Glu Lys Ile Tyr Ser Val Cys Gln Lys Ile Ile Gln Glu Ile Glu Gln 
                245                 250                 255     

Tyr Phe Arg Met Lys Val Asp Ala Val Glu Ile Asp Tyr Leu Tyr Gln 
            260                 265                 270         

Tyr Val Val Ser Ser Arg Leu Gln Lys Pro Phe Ser Ser Gly Lys Leu 
        275                 280                 285             

Pro Phe Ser Gln Arg Val Leu Asp Val Thr His Tyr Tyr Phe Ser Arg 
    290                 295                 300                 

Met Cys Met Asp Asn Arg Glu Ile Glu Thr Thr Asp Pro Asp Phe Val 
305                 310                 315                 320 

Asp Leu Ala Ser His Ile Ser Pro Leu Leu Arg Arg Leu Asp Asn Arg 
                325                 330                 335     

Val Gln Ile Lys Asn Ser Leu Leu Ser Gln Ile Leu Leu Thr Tyr Pro 
            340                 345                 350         

Asn Leu Val Lys Glu Leu Thr Thr Ile Ser Lys Glu Val Ser Leu Val 
        355                 360                 365             

Phe Gly Phe Ala Ser Leu Ser Leu Asp Glu Ile Gly Phe Leu Val Leu 
    370                 375                 380                 

Tyr Phe Ala Arg Phe Gln Glu Lys Arg Ala Arg Pro Leu Lys Thr Val 
385                 390                 395                 400 

Val Met Cys Thr Ser Gly Val Gly Thr Ser Glu Leu Leu Arg Ala Arg 
                405                 410                 415     

Leu Glu Lys Gln Phe Ser Glu Leu Asp Ile Ile Asp Val Val Ala Tyr 
            420                 425                 430         

His Gln Leu Asp Glu Leu Ile Asn Leu Tyr Pro Asp Leu Asp Phe Ile 
        435                 440                 445             

Val Thr Thr Val Ala Leu Gln Glu Pro Ala Ser Val Pro Phe Val Leu 
    450                 455                 460                 

Val Ser Val Phe Leu Thr Glu Gly Asp Lys Gln Arg Leu Gln Ala Lys 
465                 470                 475                 480 

Ile Gln Glu Ile Asn Tyr Glu 
                485         

<210>   3329
<211>   471
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   3329
atgagagagg ataatcaaag tttatcacat accacatgga attgtaaata tcatattgtt   60
tttgcaccca aatatcgtcg tcaaatcatt tatggcagat acaaagctag tatcggaaga   120
atcatacgtg acttatgtga gcgtaagggt gtaataatcc atgaagcgaa tgcttgttca   180
gaccatattc acatgcttat cagtattcct ccgaaactta gtgtttcgtc ctttatgggc   240
tatttaaagg gcaagagcag tttgatgatt tttgataagc atgcgaattt aaaatacaaa   300
tatggcaatc gcaagttttg gtgtagaggc tattatgtag atacggtagg ccgtaatcag   360
aaagtgatag ctgaatatat tcagaatcaa ttacaagaag acagagtagc agaccagctc   420
acgttattcg agtcagtaga tccgtttact ggcgaaataa ataagaggaa g            471

<210>   3330
<211>   157
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, IS200 family
<223>   Cellular location: cytoplasm

<400>   3330
Met Arg Glu Asp Asn Gln Ser Leu Ser His Thr Thr Trp Asn Cys Lys 
1               5                   10                  15      

Tyr His Ile Val Phe Ala Pro Lys Tyr Arg Arg Gln Ile Ile Tyr Gly 
            20                  25                  30          

Arg Tyr Lys Ala Ser Ile Gly Arg Ile Ile Arg Asp Leu Cys Glu Arg 
        35                  40                  45              

Lys Gly Val Ile Ile His Glu Ala Asn Ala Cys Ser Asp His Ile His 
    50                  55                  60                  

Met Leu Ile Ser Ile Pro Pro Lys Leu Ser Val Ser Ser Phe Met Gly 
65                  70                  75                  80  

Tyr Leu Lys Gly Lys Ser Ser Leu Met Ile Phe Asp Lys His Ala Asn 
                85                  90                  95      

Leu Lys Tyr Lys Tyr Gly Asn Arg Lys Phe Trp Cys Arg Gly Tyr Tyr 
            100                 105                 110         

Val Asp Thr Val Gly Arg Asn Gln Lys Val Ile Ala Glu Tyr Ile Gln 
        115                 120                 125             

Asn Gln Leu Gln Glu Asp Arg Val Ala Asp Gln Leu Thr Leu Phe Glu 
    130                 135                 140                 

Ser Val Asp Pro Phe Thr Gly Glu Ile Asn Lys Arg Lys 
145                 150                 155         

<210>   3331
<211>   2334
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3331
atggataaaa ataagattat gggattaacc caaagagaag tcaaggaaag acaggctgag   60
ggtttggtca atgactttac cgcatcagcc agtaccagca cttggcaaat cgttaaacga   120
aatgtcttta ccctttttaa cgctttgaac tttgccattg ctttggctct tgcctttgtg   180
caggcttgga gcaatctggt cttctttgct gttatctgct ttaacgcttt ttctgggatt   240
gtgaccgagc tacgagccaa acacatggtg gacaagctca atctcatgac caaggaaaag   300
gtcaaaacca tccgtgatgg tcaggaagtt gctcttaatc ctgaagaatt agtgctagga   360
gatgtcattc gtttgtctgc aggagagcag attcctagtg atgccttggt tttggaaggc   420
tttgcggaag tcaatgaagc catgttaacg ggagaaagtg atttggtgca aaaggaagtt   480
gacggcttac ttttgtcagg aagtttccta gccagtgggt cagttttatc tcaagttcac   540
catgtcggtg cagacaacta tgctgccaaa ctcatgcttg aggctaagac cgttaaaccc   600
atcaactccc gtatcatgaa atcgctggac aagttggctg gttttactgg gaagattatc   660
attccctttg gtctggctct cttgctggaa gccttgcttt taaaaggcct gcctctcaag   720
tcatccgttg taaactcgtc gacagctctt ttgggaatgt tgcctaaggg aattgccctt   780
ttgaccatta cttcgctctt gactgcagtg attaagttgg gcttgaaaaa ggtcttggtg   840
caggagatgt actctgttga gaccttggcg cgcgtggata tgctctgtct ggacaagacg   900
ggtaccatca cccaaggaaa gatgcaggtg gaggctgttc ttccgttgac ggaaacgtat   960
ggtgaagagg ctattgccag catcttgact agctacatgg cccatagtga ggataagaat   1020
ccaactgccc aagccattcg ccagcgtttt gtgggagatg ttgcttatcc tatgatttcc   1080
aatcttccct tctcgagcga ccgcaagtgg ggggctatgg agttagaagg cttggggaca   1140
gttttcttag gggcacctga gatgttgctt gattctgaag tcccagaagc tagggaggcc   1200
ttggagagag gatcacgtgt cttggtctta gctctcagtc aggagaaatt agaccatcac   1260
aaaccacaga aaccatctga tattcaggct ctagccttgc tggaaatctt ggaccccatt   1320
cgagagggag cagcagagac gctggactat ctccgttctc aggaggtggg actcaagatt   1380
atctctggtg acaatccagt tacggtgtcc agcattgccc agaaggctgg ttttgcggac   1440
tatcacagct atgtagattg ctcaaaaatc accgatgagg aattgatggc catggcggag   1500
gagacagcta ttttcggacg tgtttcccct catcaaaaga aactcatcat ccaaacgttg   1560
aaaaaagcgg gacatacaac ggctatgaca ggggacgggg ttaatgatat cttggccctt   1620
cgtgaggcgg attgttctat cgtgatggcg gagggggatc cagcaacccg tcagattgcc   1680
aatctggttc tcttgaactc agactttaat gatgttcctg agattctctt cgagggtcgt   1740
cgcgtggtca ataacattgc ccacatcgcc ccgattttct tgataaagac catctattcc   1800
ttcctgttag cagtcatctg tattgccagt gctttactag gtcggtcaga gtggattttg   1860
attttcccct tcattccgat ccagattacc atgattgacc agtttgtgga aggtttccca   1920
ccattcgttc tgacttttga gcgaaatatc aaacctgttg agcagaattt cctcagaaaa   1980
tccatgcttc gtgccctacc aagcgctctc atggtcgtct tcagcgtcct gtttgtgaaa   2040
atgtttggcg cgagtcaagg ttggtctgag ttagaaatct caactctact ctattatctc   2100
ttggggtcaa ttggtttctt atccgtattt agagcctgca tgccatttac cctatggcgt   2160
gtcctcttga ttgtttggtc agtaggaggt ttcctagcca cagctctctt cccaagaatt   2220
caaaaactgc ttgaaatttc aaccttaaca gaacaaacgt tgcctgttta tggtgtcatg   2280
atgttggtct ttaccgtgat tttcatcctg accagtcgtt accaagcgaa aaaa         2334

<210>   3332
<211>   778
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cation-transporting ATPase, E1-E2 family ( )
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903507 (0.E+01)

<400>   3332
Met Asp Lys Asn Lys Ile Met Gly Leu Thr Gln Arg Glu Val Lys Glu 
1               5                   10                  15      

Arg Gln Ala Glu Gly Leu Val Asn Asp Phe Thr Ala Ser Ala Ser Thr 
            20                  25                  30          

Ser Thr Trp Gln Ile Val Lys Arg Asn Val Phe Thr Leu Phe Asn Ala 
        35                  40                  45              

Leu Asn Phe Ala Ile Ala Leu Ala Leu Ala Phe Val Gln Ala Trp Ser 
    50                  55                  60                  

Asn Leu Val Phe Phe Ala Val Ile Cys Phe Asn Ala Phe Ser Gly Ile 
65                  70                  75                  80  

Val Thr Glu Leu Arg Ala Lys His Met Val Asp Lys Leu Asn Leu Met 
                85                  90                  95      

Thr Lys Glu Lys Val Lys Thr Ile Arg Asp Gly Gln Glu Val Ala Leu 
            100                 105                 110         

Asn Pro Glu Glu Leu Val Leu Gly Asp Val Ile Arg Leu Ser Ala Gly 
        115                 120                 125             

Glu Gln Ile Pro Ser Asp Ala Leu Val Leu Glu Gly Phe Ala Glu Val 
    130                 135                 140                 

Asn Glu Ala Met Leu Thr Gly Glu Ser Asp Leu Val Gln Lys Glu Val 
145                 150                 155                 160 

Asp Gly Leu Leu Leu Ser Gly Ser Phe Leu Ala Ser Gly Ser Val Leu 
                165                 170                 175     

Ser Gln Val His His Val Gly Ala Asp Asn Tyr Ala Ala Lys Leu Met 
            180                 185                 190         

Leu Glu Ala Lys Thr Val Lys Pro Ile Asn Ser Arg Ile Met Lys Ser 
        195                 200                 205             

Leu Asp Lys Leu Ala Gly Phe Thr Gly Lys Ile Ile Ile Pro Phe Gly 
    210                 215                 220                 

Leu Ala Leu Leu Leu Glu Ala Leu Leu Leu Lys Gly Leu Pro Leu Lys 
225                 230                 235                 240 

Ser Ser Val Val Asn Ser Ser Thr Ala Leu Leu Gly Met Leu Pro Lys 
                245                 250                 255     

Gly Ile Ala Leu Leu Thr Ile Thr Ser Leu Leu Thr Ala Val Ile Lys 
            260                 265                 270         

Leu Gly Leu Lys Lys Val Leu Val Gln Glu Met Tyr Ser Val Glu Thr 
        275                 280                 285             

Leu Ala Arg Val Asp Met Leu Cys Leu Asp Lys Thr Gly Thr Ile Thr 
    290                 295                 300                 

Gln Gly Lys Met Gln Val Glu Ala Val Leu Pro Leu Thr Glu Thr Tyr 
305                 310                 315                 320 

Gly Glu Glu Ala Ile Ala Ser Ile Leu Thr Ser Tyr Met Ala His Ser 
                325                 330                 335     

Glu Asp Lys Asn Pro Thr Ala Gln Ala Ile Arg Gln Arg Phe Val Gly 
            340                 345                 350         

Asp Val Ala Tyr Pro Met Ile Ser Asn Leu Pro Phe Ser Ser Asp Arg 
        355                 360                 365             

Lys Trp Gly Ala Met Glu Leu Glu Gly Leu Gly Thr Val Phe Leu Gly 
    370                 375                 380                 

Ala Pro Glu Met Leu Leu Asp Ser Glu Val Pro Glu Ala Arg Glu Ala 
385                 390                 395                 400 

Leu Glu Arg Gly Ser Arg Val Leu Val Leu Ala Leu Ser Gln Glu Lys 
                405                 410                 415     

Leu Asp His His Lys Pro Gln Lys Pro Ser Asp Ile Gln Ala Leu Ala 
            420                 425                 430         

Leu Leu Glu Ile Leu Asp Pro Ile Arg Glu Gly Ala Ala Glu Thr Leu 
        435                 440                 445             

Asp Tyr Leu Arg Ser Gln Glu Val Gly Leu Lys Ile Ile Ser Gly Asp 
    450                 455                 460                 

Asn Pro Val Thr Val Ser Ser Ile Ala Gln Lys Ala Gly Phe Ala Asp 
465                 470                 475                 480 

Tyr His Ser Tyr Val Asp Cys Ser Lys Ile Thr Asp Glu Glu Leu Met 
                485                 490                 495     

Ala Met Ala Glu Glu Thr Ala Ile Phe Gly Arg Val Ser Pro His Gln 
            500                 505                 510         

Lys Lys Leu Ile Ile Gln Thr Leu Lys Lys Ala Gly His Thr Thr Ala 
        515                 520                 525             

Met Thr Gly Asp Gly Val Asn Asp Ile Leu Ala Leu Arg Glu Ala Asp 
    530                 535                 540                 

Cys Ser Ile Val Met Ala Glu Gly Asp Pro Ala Thr Arg Gln Ile Ala 
545                 550                 555                 560 

Asn Leu Val Leu Leu Asn Ser Asp Phe Asn Asp Val Pro Glu Ile Leu 
                565                 570                 575     

Phe Glu Gly Arg Arg Val Val Asn Asn Ile Ala His Ile Ala Pro Ile 
            580                 585                 590         

Phe Leu Ile Lys Thr Ile Tyr Ser Phe Leu Leu Ala Val Ile Cys Ile 
        595                 600                 605             

Ala Ser Ala Leu Leu Gly Arg Ser Glu Trp Ile Leu Ile Phe Pro Phe 
    610                 615                 620                 

Ile Pro Ile Gln Ile Thr Met Ile Asp Gln Phe Val Glu Gly Phe Pro 
625                 630                 635                 640 

Pro Phe Val Leu Thr Phe Glu Arg Asn Ile Lys Pro Val Glu Gln Asn 
                645                 650                 655     

Phe Leu Arg Lys Ser Met Leu Arg Ala Leu Pro Ser Ala Leu Met Val 
            660                 665                 670         

Val Phe Ser Val Leu Phe Val Lys Met Phe Gly Ala Ser Gln Gly Trp 
        675                 680                 685             

Ser Glu Leu Glu Ile Ser Thr Leu Leu Tyr Tyr Leu Leu Gly Ser Ile 
    690                 695                 700                 

Gly Phe Leu Ser Val Phe Arg Ala Cys Met Pro Phe Thr Leu Trp Arg 
705                 710                 715                 720 

Val Leu Leu Ile Val Trp Ser Val Gly Gly Phe Leu Ala Thr Ala Leu 
                725                 730                 735     

Phe Pro Arg Ile Gln Lys Leu Leu Glu Ile Ser Thr Leu Thr Glu Gln 
            740                 745                 750         

Thr Leu Pro Val Tyr Gly Val Met Met Leu Val Phe Thr Val Ile Phe 
        755                 760                 765             

Ile Leu Thr Ser Arg Tyr Gln Ala Lys Lys 
    770                 775             

<210>   3333
<211>   747
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3333
atgttttata cttatttgcg tggattagtt gtattgctct tatggtccat caatggcaat   60
gctcactatc ataatactga taaaattcct aatcaagatg aaaattatat tttagttgcg   120
cctcaccgta cctggtggga tcctgtttat atggcctttg cgaccaagcc aaaacagttc   180
atctttatgg caaaaaaaga actctttacc aaccgtatct ttggttggtg gattcgtatg   240
tgtggcgcct ttcccatcga ccgtgaaaat cccagcgcct cagccatcaa atatcctatc   300
aacgttctca aaaaaagtga ccgctctctc atcatgtttc caagtggtag ccgccactca   360
aacgatgtca aggggggcgc agcactgatt gccaaaatgg ccaaggtccg tatcatgccg   420
gttacctaca ccggtcccat gactttgaag ggcttgatta gccgtgaacg tgtcgatatg   480
aactttggaa atccaatcga tatctcagat atcaagaaaa tgaatgatga aggcattgaa   540
acagtcgcca atcgtattca aacagaattc caacgtctgg acgaagaaac gaaacaatgg   600
cacaatgata aaaaaccaaa tccactctgg tggtttatcc gcatccctgc cctcatcctt   660
gctattatcc tcgctatcct aaccatcatc tttagcttta tcgcaagctt catctggaac   720
ccagataaga aaagagaaga acttgca                                       747

<210>   3334
<211>   249
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acyltransferase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903508 (e-148)

<400>   3334
Met Phe Tyr Thr Tyr Leu Arg Gly Leu Val Val Leu Leu Leu Trp Ser 
1               5                   10                  15      

Ile Asn Gly Asn Ala His Tyr His Asn Thr Asp Lys Ile Pro Asn Gln 
            20                  25                  30          

Asp Glu Asn Tyr Ile Leu Val Ala Pro His Arg Thr Trp Trp Asp Pro 
        35                  40                  45              

Val Tyr Met Ala Phe Ala Thr Lys Pro Lys Gln Phe Ile Phe Met Ala 
    50                  55                  60                  

Lys Lys Glu Leu Phe Thr Asn Arg Ile Phe Gly Trp Trp Ile Arg Met 
65                  70                  75                  80  

Cys Gly Ala Phe Pro Ile Asp Arg Glu Asn Pro Ser Ala Ser Ala Ile 
                85                  90                  95      

Lys Tyr Pro Ile Asn Val Leu Lys Lys Ser Asp Arg Ser Leu Ile Met 
            100                 105                 110         

Phe Pro Ser Gly Ser Arg His Ser Asn Asp Val Lys Gly Gly Ala Ala 
        115                 120                 125             

Leu Ile Ala Lys Met Ala Lys Val Arg Ile Met Pro Val Thr Tyr Thr 
    130                 135                 140                 

Gly Pro Met Thr Leu Lys Gly Leu Ile Ser Arg Glu Arg Val Asp Met 
145                 150                 155                 160 

Asn Phe Gly Asn Pro Ile Asp Ile Ser Asp Ile Lys Lys Met Asn Asp 
                165                 170                 175     

Glu Gly Ile Glu Thr Val Ala Asn Arg Ile Gln Thr Glu Phe Gln Arg 
            180                 185                 190         

Leu Asp Glu Glu Thr Lys Gln Trp His Asn Asp Lys Lys Pro Asn Pro 
        195                 200                 205             

Leu Trp Trp Phe Ile Arg Ile Pro Ala Leu Ile Leu Ala Ile Ile Leu 
    210                 215                 220                 

Ala Ile Leu Thr Ile Ile Phe Ser Phe Ile Ala Ser Phe Ile Trp Asn 
225                 230                 235                 240 

Pro Asp Lys Lys Arg Glu Glu Leu Ala 
                245                 

<210>   3335
<211>   612
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3335
atgggacaga caatcatatc tgctattggt gtttatattt ccaccagtat cgattattta   60
attattttaa ttattttatt tgcacagcta tcacagaata aacagaaatg gcatatttat   120
gcggggcaat atctaggcac aggcttactt gtaggggcga gtttagttgc tgcttatgtc   180
gttaatttcg tgcctgaaga atggatggtt ggattgcttg gtttaatccc tatctattta   240
gggattcgct ttgcaattgt tggagaagat gcggaagaag aagaggaaga aattattgaa   300
agattagaac aaagcaaggc aaatcaactg ttttggacag ttacattgct gacaattgcg   360
tctggcggag ataatttagg tatctatata ccttattttg cttcgttaga ttggtcacag   420
accctcgtgg ccttgcttgt gtttgtaatc ggcataatta tcttttgcga gattagtcgg   480
gtgttatcct ctattccgtt aatattcgag acaattgaaa aatacgagcg aatcattgtg   540
cccttagtat tcattctact tggactatac atcatgtatg aaaatggcac gatagagact   600
tttctgatcg tg                                                       612

<210>   3336
<211>   204
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cadmium resistance transporter, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903509 (e-112)

<400>   3336
Met Gly Gln Thr Ile Ile Ser Ala Ile Gly Val Tyr Ile Ser Thr Ser 
1               5                   10                  15      

Ile Asp Tyr Leu Ile Ile Leu Ile Ile Leu Phe Ala Gln Leu Ser Gln 
            20                  25                  30          

Asn Lys Gln Lys Trp His Ile Tyr Ala Gly Gln Tyr Leu Gly Thr Gly 
        35                  40                  45              

Leu Leu Val Gly Ala Ser Leu Val Ala Ala Tyr Val Val Asn Phe Val 
    50                  55                  60                  

Pro Glu Glu Trp Met Val Gly Leu Leu Gly Leu Ile Pro Ile Tyr Leu 
65                  70                  75                  80  

Gly Ile Arg Phe Ala Ile Val Gly Glu Asp Ala Glu Glu Glu Glu Glu 
                85                  90                  95      

Glu Ile Ile Glu Arg Leu Glu Gln Ser Lys Ala Asn Gln Leu Phe Trp 
            100                 105                 110         

Thr Val Thr Leu Leu Thr Ile Ala Ser Gly Gly Asp Asn Leu Gly Ile 
        115                 120                 125             

Tyr Ile Pro Tyr Phe Ala Ser Leu Asp Trp Ser Gln Thr Leu Val Ala 
    130                 135                 140                 

Leu Leu Val Phe Val Ile Gly Ile Ile Ile Phe Cys Glu Ile Ser Arg 
145                 150                 155                 160 

Val Leu Ser Ser Ile Pro Leu Ile Phe Glu Thr Ile Glu Lys Tyr Glu 
                165                 170                 175     

Arg Ile Ile Val Pro Leu Val Phe Ile Leu Leu Gly Leu Tyr Ile Met 
            180                 185                 190         

Tyr Glu Asn Gly Thr Ile Glu Thr Phe Leu Ile Val 
        195                 200                 

<210>   3337
<211>   267
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3337
atggcaatct caaaagagaa aaaaaatgaa atcatcgcac aatatgcacg tcacgaaggt   60
gatacaggtt cagtagaggt tcaagttgct gtccttactt gggaaatcaa ccaccttaac   120
gaacacatca aacaacacaa aaaagaccac gctacttacc gtggattgat gaaaaaaatc   180
ggtcgccgtc gtaacttgct tgcatacttg cgtaaaaacg acgttaaccg ttaccgtgag   240
ttgatcaact ctctaggact tcgtcgc                                       267

<210>   3338
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S15 (rpsO)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903510 (6.E-48)

<400>   3338
Met Ala Ile Ser Lys Glu Lys Lys Asn Glu Ile Ile Ala Gln Tyr Ala 
1               5                   10                  15      

Arg His Glu Gly Asp Thr Gly Ser Val Glu Val Gln Val Ala Val Leu 
            20                  25                  30          

Thr Trp Glu Ile Asn His Leu Asn Glu His Ile Lys Gln His Lys Lys 
        35                  40                  45              

Asp His Ala Thr Tyr Arg Gly Leu Met Lys Lys Ile Gly Arg Arg Arg 
    50                  55                  60                  

Asn Leu Leu Ala Tyr Leu Arg Lys Asn Asp Val Asn Arg Tyr Arg Glu 
65                  70                  75                  80  

Leu Ile Asn Ser Leu Gly Leu Arg Arg 
                85                  

<210>   3339
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3339
atgaaactag cagttattgc agcaaatgga caagcgggga aagcaattgt tgaagaagca   60
gtcaaacgag gacatgaagt aacggctatt gttcgttctg aaaacaaaag tcaagctgag   120
tctattatta aaaaagattt atttgagttg acaaaagatg atcttactgg atttgatgct   180
gttatttcag cgtttggtgc ttatacacca gatacgctac cgctccacag caaatcaatc   240
gaactattta atcagcttct tgctggaaca cagacacgtt ttctagttgt agggggagca   300
ggaagtcttt atatagatga aacaaaaacg acacgacttt tagatacgcc tgattttcct   360
gaagaattta agccactagc aaaagctcaa gcggatgaat tggatcttct tcgtacaaaa   420
aataatctca actggacttt tgtcagtcct gctgtagatt ttattcccga tggtgaaaaa   480
acaggaaact acattctagc aggagaaatt tttactacta atgaaaaagg aataagccag   540
attagttatg cagattatgc tattggattg gtagatgaac ttgaaaaagg tcatcatata   600
aaagaacgta tctctttact tgaaaaa                                       627

<210>   3340
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903511 (e-115)

<400>   3340
Met Lys Leu Ala Val Ile Ala Ala Asn Gly Gln Ala Gly Lys Ala Ile 
1               5                   10                  15      

Val Glu Glu Ala Val Lys Arg Gly His Glu Val Thr Ala Ile Val Arg 
            20                  25                  30          

Ser Glu Asn Lys Ser Gln Ala Glu Ser Ile Ile Lys Lys Asp Leu Phe 
        35                  40                  45              

Glu Leu Thr Lys Asp Asp Leu Thr Gly Phe Asp Ala Val Ile Ser Ala 
    50                  55                  60                  

Phe Gly Ala Tyr Thr Pro Asp Thr Leu Pro Leu His Ser Lys Ser Ile 
65                  70                  75                  80  

Glu Leu Phe Asn Gln Leu Leu Ala Gly Thr Gln Thr Arg Phe Leu Val 
                85                  90                  95      

Val Gly Gly Ala Gly Ser Leu Tyr Ile Asp Glu Thr Lys Thr Thr Arg 
            100                 105                 110         

Leu Leu Asp Thr Pro Asp Phe Pro Glu Glu Phe Lys Pro Leu Ala Lys 
        115                 120                 125             

Ala Gln Ala Asp Glu Leu Asp Leu Leu Arg Thr Lys Asn Asn Leu Asn 
    130                 135                 140                 

Trp Thr Phe Val Ser Pro Ala Val Asp Phe Ile Pro Asp Gly Glu Lys 
145                 150                 155                 160 

Thr Gly Asn Tyr Ile Leu Ala Gly Glu Ile Phe Thr Thr Asn Glu Lys 
                165                 170                 175     

Gly Ile Ser Gln Ile Ser Tyr Ala Asp Tyr Ala Ile Gly Leu Val Asp 
            180                 185                 190         

Glu Leu Glu Lys Gly His His Ile Lys Glu Arg Ile Ser Leu Leu Glu 
        195                 200                 205             

Lys 
    

<210>   3341
<211>   207
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3341
gtgattatca tgcgtagatt ctattcccat ctcccctact atctggtcat attattcttt   60
tattggccac tttatgagtt gttcttacta gttgtttctg acccccttac actcaaggga   120
ctctatataa acaatcttct cttctttaca cctctggtaa tcttgattgt atcgttactc   180
tatagctacc gtttccgttt ctcactt                                       207

<210>   3342
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903512 (4.E-35)

<400>   3342
Met Ile Ile Met Arg Arg Phe Tyr Ser His Leu Pro Tyr Tyr Leu Val 
1               5                   10                  15      

Ile Leu Phe Phe Tyr Trp Pro Leu Tyr Glu Leu Phe Leu Leu Val Val 
            20                  25                  30          

Ser Asp Pro Leu Thr Leu Lys Gly Leu Tyr Ile Asn Asn Leu Leu Phe 
        35                  40                  45              

Phe Thr Pro Leu Val Ile Leu Ile Val Ser Leu Leu Tyr Ser Tyr Arg 
    50                  55                  60                  

Phe Arg Phe Ser Leu 
65                  

<210>   3343
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3343
ttgctaatct atgaaacagt tgctctggtc ggcatggatt ctggtattag catcaagcat   60
attctacaaa aaatgaaaaa caaaaaactt tcacaaaatc ct                      102

<210>   3344
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3344
Met Leu Ile Tyr Glu Thr Val Ala Leu Val Gly Met Asp Ser Gly Ile 
1               5                   10                  15      

Ser Ile Lys His Ile Leu Gln Lys Met Lys Asn Lys Lys Leu Ser Gln 
            20                  25                  30          

Asn Pro 
        

<210>   3345
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3345
atgaaggtgg aaccacgttg cgacgtcctt tcgaggatgt cgcatttttt tattaggata   60
ctaattatgg agttgcaaga attagtggag cgcagttggg caatccgaca agcttatcac   120
gaactggaag ttaagcatca tgattccaag tggacggtag aagaagacct cttggcttta   180
tctaatgata ttggaaattt ccaacgactg gtgatgacaa agcaaggacg ctactatgat   240
gaaacaccct acacactgga acaaaaactt tcagaaaata tctggtggct attagaactt   300
tctcaacgtt tggatataga cattctgacg gaaatggaaa acttcctctc tgataaagaa   360
aagcaattga acgttaggac ttggaag                                       387

<210>   3346
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903513 (5.E-35)

<400>   3346
Met Lys Val Glu Pro Arg Cys Asp Val Leu Ser Arg Met Ser His Phe 
1               5                   10                  15      

Phe Ile Arg Ile Leu Ile Met Glu Leu Gln Glu Leu Val Glu Arg Ser 
            20                  25                  30          

Trp Ala Ile Arg Gln Ala Tyr His Glu Leu Glu Val Lys His His Asp 
        35                  40                  45              

Ser Lys Trp Thr Val Glu Glu Asp Leu Leu Ala Leu Ser Asn Asp Ile 
    50                  55                  60                  

Gly Asn Phe Gln Arg Leu Val Met Thr Lys Gln Gly Arg Tyr Tyr Asp 
65                  70                  75                  80  

Glu Thr Pro Tyr Thr Leu Glu Gln Lys Leu Ser Glu Asn Ile Trp Trp 
                85                  90                  95      

Leu Leu Glu Leu Ser Gln Arg Leu Asp Ile Asp Ile Leu Thr Glu Met 
            100                 105                 110         

Glu Asn Phe Leu Ser Asp Lys Glu Lys Gln Leu Asn Val Arg Thr Trp 
        115                 120                 125             

Lys 
    

<210>   3347
<211>   1941
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3347
atgattaaca ttactttccc agatggcgct gttcgtgaat tcgaatctgg cgtaacaact   60
tttgaaattg cccaatctat cagcaattcc ctagctaaaa aagccttggc tggtaaattc   120
aacggcaaac tcatcgacac tactcgcgct atcactgaag atggaagcat cgaaattgtg   180
acacctgatc acgaagatgc ccttccaatc ttgcgtcact cagcagctca cttgttcgcc   240
caagcagctc gtcgtctttt cccagacatt cacttgggag ttggtccagc catcgaagat   300
ggtttctact acgatactga caacacagct ggtcaaatct ctaacgaaga ccttcctcgt   360
atcgaagaag aaatgcaaaa aatcgtcaaa gaaaacttcc catctattcg tgaagaagtg   420
actaaagacg aggcacgtga aatcttcaaa aatgaccctt acaagttgga attgattgaa   480
gaacactcag aagacgaagg cggtttgact atctatcgtc agggtgaata tgtagacctc   540
tgccgtggac ctcacgttcc atcaacaggt cgtatccaaa tcttccacct tctccatgta   600
gctggtgcgt actggcgtgg aaacagcgac aacgctatga tgcaacgtat ctacggtaca   660
gcttggtttg acaagaaaga cttgaaaaac taccttcaaa tgcgtgaaga agctaaggaa   720
cgtgaccacc gtaaacttgg taaagagctt gacctcttta tgatttcaca agaagtggga   780
caaggtttgc cattctggtt gccaaatggt gcgactatcc gtcgtgaatt ggaacgctac   840
atcgtaaaca aagagttggt ttctggctac caacacgtct acactccacc acttgcttct   900
gttgagcttt acaagacttc tggtcactgg gatcattacc aagaagacat gttcccaacc   960
atggacatgg gtgacgggga agaatttgtc cttcgtccaa tgaactgtcc gcaccacatc   1020
caagttttca aacaccatgt tcactcttac cgtgaattgc caatccgtat cgctgaaatc   1080
ggtatgatgc accgttacga aaaatctggt gccctcactg gccttcaacg tgtacgtgaa   1140
atgtcactca acgacggtca cctattcgtt actccagaac aaatccaaga agaattccaa   1200
cgtgcccttc agttgattat cgatgtttat gaagacttca acttgactga ctaccgcttc   1260
cgcctctctc ttcgtgaccc tcaagatact cataagtact ttgataacga tgagatgtgg   1320
gaaaatgccc aaaccatgct tcgtgcagct cttgatgaaa tgggcgtgga ctactttgaa   1380
gccgaaggtg aagcagcctt ctacggacca aaattggata tccagattaa aactgccctt   1440
ggaaaagaag aaaccctttc tactatccaa cttgatttct tgttgccaga acgcttcgac   1500
ctcaaataca tcggagctga tggcgaagat caccgtccag tcatgatcca ccgtggggtt   1560
atctcaacta tggaacgctt cacagctatc ttgattgaga actacaaggg ggccttccca   1620
acatggctgg caccacacca agtaaccctc atcccagtat ctaacgaaaa acacgtggac   1680
tacgcttggg aagtggccaa gaaactccgt gaccgcggtg tccgtgcaga cgtagatgag   1740
cgcaatgaaa aaatgcagtt caagatccgt gcttcacaaa ccagcaagat tccttaccaa   1800
ttaattgttg gagacaaaga aatggaagac gaaacagtca acgttcgtcg ctacggccaa   1860
aaagaaacac aaactgtctc agttgataat tttgttcaag ctatcctagc tgatatcgcc   1920
aacaaatcac gcgttgagaa a                                             1941

<210>   3348
<211>   647
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   threonyl-tRNA synthetase (thrS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903515 (0.E+01)

<400>   3348
Met Ile Asn Ile Thr Phe Pro Asp Gly Ala Val Arg Glu Phe Glu Ser 
1               5                   10                  15      

Gly Val Thr Thr Phe Glu Ile Ala Gln Ser Ile Ser Asn Ser Leu Ala 
            20                  25                  30          

Lys Lys Ala Leu Ala Gly Lys Phe Asn Gly Lys Leu Ile Asp Thr Thr 
        35                  40                  45              

Arg Ala Ile Thr Glu Asp Gly Ser Ile Glu Ile Val Thr Pro Asp His 
    50                  55                  60                  

Glu Asp Ala Leu Pro Ile Leu Arg His Ser Ala Ala His Leu Phe Ala 
65                  70                  75                  80  

Gln Ala Ala Arg Arg Leu Phe Pro Asp Ile His Leu Gly Val Gly Pro 
                85                  90                  95      

Ala Ile Glu Asp Gly Phe Tyr Tyr Asp Thr Asp Asn Thr Ala Gly Gln 
            100                 105                 110         

Ile Ser Asn Glu Asp Leu Pro Arg Ile Glu Glu Glu Met Gln Lys Ile 
        115                 120                 125             

Val Lys Glu Asn Phe Pro Ser Ile Arg Glu Glu Val Thr Lys Asp Glu 
    130                 135                 140                 

Ala Arg Glu Ile Phe Lys Asn Asp Pro Tyr Lys Leu Glu Leu Ile Glu 
145                 150                 155                 160 

Glu His Ser Glu Asp Glu Gly Gly Leu Thr Ile Tyr Arg Gln Gly Glu 
                165                 170                 175     

Tyr Val Asp Leu Cys Arg Gly Pro His Val Pro Ser Thr Gly Arg Ile 
            180                 185                 190         


Gln Ile Phe His Leu Leu His Val Ala Gly Ala Tyr Trp Arg Gly Asn 
        195                 200                 205             

Ser Asp Asn Ala Met Met Gln Arg Ile Tyr Gly Thr Ala Trp Phe Asp 
    210                 215                 220                 

Lys Lys Asp Leu Lys Asn Tyr Leu Gln Met Arg Glu Glu Ala Lys Glu 
225                 230                 235                 240 

Arg Asp His Arg Lys Leu Gly Lys Glu Leu Asp Leu Phe Met Ile Ser 
                245                 250                 255     

Gln Glu Val Gly Gln Gly Leu Pro Phe Trp Leu Pro Asn Gly Ala Thr 
            260                 265                 270         

Ile Arg Arg Glu Leu Glu Arg Tyr Ile Val Asn Lys Glu Leu Val Ser 
        275                 280                 285             

Gly Tyr Gln His Val Tyr Thr Pro Pro Leu Ala Ser Val Glu Leu Tyr 
    290                 295                 300                 

Lys Thr Ser Gly His Trp Asp His Tyr Gln Glu Asp Met Phe Pro Thr 
305                 310                 315                 320 

Met Asp Met Gly Asp Gly Glu Glu Phe Val Leu Arg Pro Met Asn Cys 
                325                 330                 335     

Pro His His Ile Gln Val Phe Lys His His Val His Ser Tyr Arg Glu 
            340                 345                 350         

Leu Pro Ile Arg Ile Ala Glu Ile Gly Met Met His Arg Tyr Glu Lys 
        355                 360                 365             

Ser Gly Ala Leu Thr Gly Leu Gln Arg Val Arg Glu Met Ser Leu Asn 
    370                 375                 380                 

Asp Gly His Leu Phe Val Thr Pro Glu Gln Ile Gln Glu Glu Phe Gln 
385                 390                 395                 400 

Arg Ala Leu Gln Leu Ile Ile Asp Val Tyr Glu Asp Phe Asn Leu Thr 
                405                 410                 415     

Asp Tyr Arg Phe Arg Leu Ser Leu Arg Asp Pro Gln Asp Thr His Lys 
            420                 425                 430         

Tyr Phe Asp Asn Asp Glu Met Trp Glu Asn Ala Gln Thr Met Leu Arg 
        435                 440                 445             

Ala Ala Leu Asp Glu Met Gly Val Asp Tyr Phe Glu Ala Glu Gly Glu 
    450                 455                 460                 

Ala Ala Phe Tyr Gly Pro Lys Leu Asp Ile Gln Ile Lys Thr Ala Leu 
465                 470                 475                 480 

Gly Lys Glu Glu Thr Leu Ser Thr Ile Gln Leu Asp Phe Leu Leu Pro 
                485                 490                 495     

Glu Arg Phe Asp Leu Lys Tyr Ile Gly Ala Asp Gly Glu Asp His Arg 
            500                 505                 510         

Pro Val Met Ile His Arg Gly Val Ile Ser Thr Met Glu Arg Phe Thr 
        515                 520                 525             


Ala Ile Leu Ile Glu Asn Tyr Lys Gly Ala Phe Pro Thr Trp Leu Ala 
    530                 535                 540                 

Pro His Gln Val Thr Leu Ile Pro Val Ser Asn Glu Lys His Val Asp 
545                 550                 555                 560 

Tyr Ala Trp Glu Val Ala Lys Lys Leu Arg Asp Arg Gly Val Arg Ala 
                565                 570                 575     

Asp Val Asp Glu Arg Asn Glu Lys Met Gln Phe Lys Ile Arg Ala Ser 
            580                 585                 590         

Gln Thr Ser Lys Ile Pro Tyr Gln Leu Ile Val Gly Asp Lys Glu Met 
        595                 600                 605             

Glu Asp Glu Thr Val Asn Val Arg Arg Tyr Gly Gln Lys Glu Thr Gln 
    610                 615                 620                 

Thr Val Ser Val Asp Asn Phe Val Gln Ala Ile Leu Ala Asp Ile Ala 
625                 630                 635                 640 

Asn Lys Ser Arg Val Glu Lys 
                645         

<210>   3349
<211>   972
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3349
atgcttgatt ggaaacaatt ttttctagcc tatctgcgct cccgtagtcg tctttttatc   60
tatctgcttt ctttggcatt tcttgtctta ctctttcagt ttttatttgc cagtctagga   120
atttacttcc tctacttttt cttcttgtgt tgctttgtaa ccatattatt tttcacttgg   180
gacatattgg tggaaacgca ggtctatcgc caggaacttc tctatggaga gagggaagcc   240
aagtctcctt tggaaatagc tttagcagaa aaattagaag cgcgtgagat ggaactctat   300
cagcagaggt caaaagcaga aagaaaactg acggatttgc tggattacta taccttgtgg   360
gtccatcaga taaagacccc cattgcagcc agtcaactct tagttgcaga agtggtcgac   420
cgccaactga agcagcagct agaacaggaa attttcaaaa tcgactccta taccaaccta   480
gttttacagt acctgcgttt agaaagtttc catgatgatt tggtcttaaa gcaggttcaa   540
attgaggact tggtcaagga aataattcgt aaatatgctc ttttctttat tcaaaaaggc   600
ttaaatgtca atctacatga ccttgataaa gaaatcgtga cggataaaaa gtggctgcta   660
gtggttattg agcaaatcat ctcaaacagt ctcaagtaca ccaaggaagg tggtctggag   720
atttatatgg atgaccaaga gctttgtatc aaagatacgg gaatcgggat aaaaaacagt   780
gatgtcctcc gagtatttga acgtggcttt tcaggataca atggccgttt gacccagcag   840
tcctctggac ttggccttta tctatctaag aaaatttctg aagaactggg gcaccagatt   900
cgtatcgagt ctgaggtcgg aaaaggaacg acagtgcgga ttcagtttgc tcaagtgaac   960
ttagtccttg ag                                                       972

<210>   3350
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903516 (0.E+01)

<400>   3350
Met Leu Asp Trp Lys Gln Phe Phe Leu Ala Tyr Leu Arg Ser Arg Ser 
1               5                   10                  15      

Arg Leu Phe Ile Tyr Leu Leu Ser Leu Ala Phe Leu Val Leu Leu Phe 
            20                  25                  30          

Gln Phe Leu Phe Ala Ser Leu Gly Ile Tyr Phe Leu Tyr Phe Phe Phe 
        35                  40                  45              

Leu Cys Cys Phe Val Thr Ile Leu Phe Phe Thr Trp Asp Ile Leu Val 
    50                  55                  60                  

Glu Thr Gln Val Tyr Arg Gln Glu Leu Leu Tyr Gly Glu Arg Glu Ala 
65                  70                  75                  80  

Lys Ser Pro Leu Glu Ile Ala Leu Ala Glu Lys Leu Glu Ala Arg Glu 
                85                  90                  95      

Met Glu Leu Tyr Gln Gln Arg Ser Lys Ala Glu Arg Lys Leu Thr Asp 
            100                 105                 110         

Leu Leu Asp Tyr Tyr Thr Leu Trp Val His Gln Ile Lys Thr Pro Ile 
        115                 120                 125             

Ala Ala Ser Gln Leu Leu Val Ala Glu Val Val Asp Arg Gln Leu Lys 
    130                 135                 140                 

Gln Gln Leu Glu Gln Glu Ile Phe Lys Ile Asp Ser Tyr Thr Asn Leu 
145                 150                 155                 160 

Val Leu Gln Tyr Leu Arg Leu Glu Ser Phe His Asp Asp Leu Val Leu 
                165                 170                 175     

Lys Gln Val Gln Ile Glu Asp Leu Val Lys Glu Ile Ile Arg Lys Tyr 
            180                 185                 190         

Ala Leu Phe Phe Ile Gln Lys Gly Leu Asn Val Asn Leu His Asp Leu 
        195                 200                 205             

Asp Lys Glu Ile Val Thr Asp Lys Lys Trp Leu Leu Val Val Ile Glu 
    210                 215                 220                 

Gln Ile Ile Ser Asn Ser Leu Lys Tyr Thr Lys Glu Gly Gly Leu Glu 
225                 230                 235                 240 

Ile Tyr Met Asp Asp Gln Glu Leu Cys Ile Lys Asp Thr Gly Ile Gly 
                245                 250                 255     


Ile Lys Asn Ser Asp Val Leu Arg Val Phe Glu Arg Gly Phe Ser Gly 
            260                 265                 270         

Tyr Asn Gly Arg Leu Thr Gln Gln Ser Ser Gly Leu Gly Leu Tyr Leu 
        275                 280                 285             

Ser Lys Lys Ile Ser Glu Glu Leu Gly His Gln Ile Arg Ile Glu Ser 
    290                 295                 300                 

Glu Val Gly Lys Gly Thr Thr Val Arg Ile Gln Phe Ala Gln Val Asn 
305                 310                 315                 320 

Leu Val Leu Glu 
                

<210>   3351
<211>   765
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3351
ttgtactggc taaaaacagg ctatttcaaa ttcagtttca gaccatctag catggaaaaa   60
tctgttataa taatggaaaa ggagaagcgc atgcacaaga ttttattaat agaagatgat   120
caggtcattc gtcaacagat tgggaaaatg ctctctgaat ggggatttga agtggtcctg   180
gtagaagact ttatggaagt tttgagtcta tttgttcagt cggaacctca tctggtcctc   240
atggatattg gtttgccctt gtttaatggt tatcactggt gtcaggaaat ccgcaagatt   300
tccaaggtac ctatcatgtt tctttcttcg agagaccagg ctatggatat tgtcatggca   360
atcaatatgg gggcggatga ctttgtgacc aagccttttg accagcaggt tcttttagct   420
aaggttcagg gcttgttgcg tcgttcctat gagtttgggc gtgatgagag tttgctggaa   480
tatgctggtg ttatcctcaa taccaaatcc atggatttac attatcaagg gcaagtcttg   540
aatttgacca agaatgaatt ccagatttta cgcgtgttat ttgagcatgc aggcaacatc   600
gtagcacgtg acgacctgat gcgggaactt tggaacagtg actttttcat tgatgataat   660
accctctctg tcaatgtggc tcgtttgcgt aaaaagttgg aggagcaggg attggtagga   720
tttatcgaga ccaagaaagg aatagggtac ggattgaagc atgct                   765

<210>   3352
<211>   255
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903517 (e-127)

<400>   3352
Met Tyr Trp Leu Lys Thr Gly Tyr Phe Lys Phe Ser Phe Arg Pro Ser 
1               5                   10                  15      

Ser Met Glu Lys Ser Val Ile Ile Met Glu Lys Glu Lys Arg Met His 
            20                  25                  30          

Lys Ile Leu Leu Ile Glu Asp Asp Gln Val Ile Arg Gln Gln Ile Gly 
        35                  40                  45              

Lys Met Leu Ser Glu Trp Gly Phe Glu Val Val Leu Val Glu Asp Phe 
    50                  55                  60                  

Met Glu Val Leu Ser Leu Phe Val Gln Ser Glu Pro His Leu Val Leu 
65                  70                  75                  80  

Met Asp Ile Gly Leu Pro Leu Phe Asn Gly Tyr His Trp Cys Gln Glu 
                85                  90                  95      

Ile Arg Lys Ile Ser Lys Val Pro Ile Met Phe Leu Ser Ser Arg Asp 
            100                 105                 110         

Gln Ala Met Asp Ile Val Met Ala Ile Asn Met Gly Ala Asp Asp Phe 
        115                 120                 125             

Val Thr Lys Pro Phe Asp Gln Gln Val Leu Leu Ala Lys Val Gln Gly 
    130                 135                 140                 

Leu Leu Arg Arg Ser Tyr Glu Phe Gly Arg Asp Glu Ser Leu Leu Glu 
145                 150                 155                 160 

Tyr Ala Gly Val Ile Leu Asn Thr Lys Ser Met Asp Leu His Tyr Gln 
                165                 170                 175     

Gly Gln Val Leu Asn Leu Thr Lys Asn Glu Phe Gln Ile Leu Arg Val 
            180                 185                 190         

Leu Phe Glu His Ala Gly Asn Ile Val Ala Arg Asp Asp Leu Met Arg 
        195                 200                 205             

Glu Leu Trp Asn Ser Asp Phe Phe Ile Asp Asp Asn Thr Leu Ser Val 
    210                 215                 220                 

Asn Val Ala Arg Leu Arg Lys Lys Leu Glu Glu Gln Gly Leu Val Gly 
225                 230                 235                 240 

Phe Ile Glu Thr Lys Lys Gly Ile Gly Tyr Gly Leu Lys His Ala 
                245                 250                 255 

<210>   3353
<211>   1071
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3353
atggccaata tttttgacta tctgaaagat gtcgcatatg attcttatta cgaccttccc   60
ttgaatgagt tagacattct aaccttaata gaaatcacct acctctcctt tgataatctg   120
gtctccacac ttcctcaacg tcttttagat ctagcacctc aggttccaag agatcccacc   180
atgcttacta gcaaaaatcg ccttcaatta ttagatgaat tggctcaaca caagcgcttc   240
aaaaattgca aactctccca ttttatcaac gacatcgacc ctgaactgca aaagcaattt   300
gcggctatga cttatcgtgt cagcctcgat acctatctga ttgtctttcg tgggacagat   360
gacagtatca ttggctggaa ggaagatttc cacctgacct atatgaagga aattcctgct   420
caaaagcacg cccttcgcta tttaaagaac ttttttgccc atcatcctaa gcaaaaggtt   480
attctagctg ggcattccaa gggaggaaat ctcgctatct atgctgctag ccaaattgag   540
caaagtttgc aaaatcagat cacagcagtt tatacatttg atgcacctgg tctccatcaa   600
gaattgacac agactgcggg ttatcaaagg ataatggata gaagcaagat attcattcca   660
caaggttcca ttatcggtat gatgctggaa attcctgctc accaaatcat cgttcagagt   720
actgccctgg gtggcatcgc ccagcacgat acctttagtt ggcagattga ggacaagcac   780
ttcgtccaac tggataagac caacagtgat agccagcaag tagacacaac ctttaaagaa   840
tgggtggcca cagtccctga cgaagaactt cagctctact tcgacctctt ctttggcact   900
attcttgatg ctggtattag ctctatcaat gacttggctt ccttaaaggc gcttgaatac   960
attcatcatc tctttgtcca agctcaatcc ctcactccag aagaaagaga aaccttgggt   1020
cgccttaccc agttattgat tgatactcgt taccaggcat ggaaaaatag a            1071

<210>   3354
<211>   357
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903518 (0.E+01)

<400>   3354
Met Ala Asn Ile Phe Asp Tyr Leu Lys Asp Val Ala Tyr Asp Ser Tyr 
1               5                   10                  15      

Tyr Asp Leu Pro Leu Asn Glu Leu Asp Ile Leu Thr Leu Ile Glu Ile 
            20                  25                  30          

Thr Tyr Leu Ser Phe Asp Asn Leu Val Ser Thr Leu Pro Gln Arg Leu 
        35                  40                  45              

Leu Asp Leu Ala Pro Gln Val Pro Arg Asp Pro Thr Met Leu Thr Ser 
    50                  55                  60                  

Lys Asn Arg Leu Gln Leu Leu Asp Glu Leu Ala Gln His Lys Arg Phe 
65                  70                  75                  80  

Lys Asn Cys Lys Leu Ser His Phe Ile Asn Asp Ile Asp Pro Glu Leu 
                85                  90                  95      

Gln Lys Gln Phe Ala Ala Met Thr Tyr Arg Val Ser Leu Asp Thr Tyr 
            100                 105                 110         

Leu Ile Val Phe Arg Gly Thr Asp Asp Ser Ile Ile Gly Trp Lys Glu 
        115                 120                 125             

Asp Phe His Leu Thr Tyr Met Lys Glu Ile Pro Ala Gln Lys His Ala 
    130                 135                 140                 

Leu Arg Tyr Leu Lys Asn Phe Phe Ala His His Pro Lys Gln Lys Val 
145                 150                 155                 160 

Ile Leu Ala Gly His Ser Lys Gly Gly Asn Leu Ala Ile Tyr Ala Ala 
                165                 170                 175     

Ser Gln Ile Glu Gln Ser Leu Gln Asn Gln Ile Thr Ala Val Tyr Thr 
            180                 185                 190         

Phe Asp Ala Pro Gly Leu His Gln Glu Leu Thr Gln Thr Ala Gly Tyr 
        195                 200                 205             


Gln Arg Ile Met Asp Arg Ser Lys Ile Phe Ile Pro Gln Gly Ser Ile 
    210                 215                 220                 

Ile Gly Met Met Leu Glu Ile Pro Ala His Gln Ile Ile Val Gln Ser 
225                 230                 235                 240 

Thr Ala Leu Gly Gly Ile Ala Gln His Asp Thr Phe Ser Trp Gln Ile 
                245                 250                 255     

Glu Asp Lys His Phe Val Gln Leu Asp Lys Thr Asn Ser Asp Ser Gln 
            260                 265                 270         

Gln Val Asp Thr Thr Phe Lys Glu Trp Val Ala Thr Val Pro Asp Glu 
        275                 280                 285             

Glu Leu Gln Leu Tyr Phe Asp Leu Phe Phe Gly Thr Ile Leu Asp Ala 
    290                 295                 300                 

Gly Ile Ser Ser Ile Asn Asp Leu Ala Ser Leu Lys Ala Leu Glu Tyr 
305                 310                 315                 320 

Ile His His Leu Phe Val Gln Ala Gln Ser Leu Thr Pro Glu Glu Arg 
                325                 330                 335     

Glu Thr Leu Gly Arg Leu Thr Gln Leu Leu Ile Asp Thr Arg Tyr Gln 
            340                 345                 350         

Ala Trp Lys Asn Arg 
        355         

<210>   3355
<211>   300
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3355
atgtatctcg ttataggaat tgtattagcc tttatagtgt cattttggaa ggataataga   60
agtttgtgga atccagtatt atttttatta tccctcattt caagttattt ttatctatcc   120
tacctttttt ataaaaatgg atacgagaat gttcagttag ctttttatat atttgccttt   180
gtcttacttc cttttttgct ttttctaagt ggcatctttt taatctataa tggggtcatt   240
ttgttgaagc gagagggacg ttccaagccc cattatctct caatgctctt tgatttttat   300

<210>   3356
<211>   100
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903519 (1.E-53)

<400>   3356
Met Tyr Leu Val Ile Gly Ile Val Leu Ala Phe Ile Val Ser Phe Trp 
1               5                   10                  15      

Lys Asp Asn Arg Ser Leu Trp Asn Pro Val Leu Phe Leu Leu Ser Leu 
            20                  25                  30          

Ile Ser Ser Tyr Phe Tyr Leu Ser Tyr Leu Phe Tyr Lys Asn Gly Tyr 
        35                  40                  45              

Glu Asn Val Gln Leu Ala Phe Tyr Ile Phe Ala Phe Val Leu Leu Pro 
    50                  55                  60                  

Phe Leu Leu Phe Leu Ser Gly Ile Phe Leu Ile Tyr Asn Gly Val Ile 
65                  70                  75                  80  

Leu Leu Lys Arg Glu Gly Arg Ser Lys Pro His Tyr Leu Ser Met Leu 
                85                  90                  95      

Phe Asp Phe Tyr 
            100 

<210>   3357
<211>   435
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3357
atgcaaattc caagtagatt taccattgcg actcatatgc tgataatcat tgccctcgag   60
gggaaggaaa gcaaggtgac cagtgatttt ctggctgcta gtgtcggggt caatcctgtc   120
attatcagaa agatcttgtc ccagttgaag aaggcagagc tgatttcagt agcgcgtgga   180
acgggcggaa cagagattgt caaggacctt aaggatatta gtcttttaga tgtttatcag   240
gcggtcgaat gtcttggtaa gacaggtcaa ctcttcagtt tccatgacaa tccgaatcca   300
aattgccctg taggagctca tattcatgat gttttggatc aaaaattgga gagaattcag   360
ttgactatgg aggcagaact tggtcaaacc agtctagaaa aagtcgtggc cgatgcagag   420
agtcagatga aggat                                                    435

<210>   3358
<211>   145
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Rrf2 family protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903520 (5.E-78)

<400>   3358
Met Gln Ile Pro Ser Arg Phe Thr Ile Ala Thr His Met Leu Ile Ile 
1               5                   10                  15      

Ile Ala Leu Glu Gly Lys Glu Ser Lys Val Thr Ser Asp Phe Leu Ala 
            20                  25                  30          

Ala Ser Val Gly Val Asn Pro Val Ile Ile Arg Lys Ile Leu Ser Gln 
        35                  40                  45              

Leu Lys Lys Ala Glu Leu Ile Ser Val Ala Arg Gly Thr Gly Gly Thr 
    50                  55                  60                  

Glu Ile Val Lys Asp Leu Lys Asp Ile Ser Leu Leu Asp Val Tyr Gln 
65                  70                  75                  80  

Ala Val Glu Cys Leu Gly Lys Thr Gly Gln Leu Phe Ser Phe His Asp 
                85                  90                  95      

Asn Pro Asn Pro Asn Cys Pro Val Gly Ala His Ile His Asp Val Leu 

            100                 105                 110         

Asp Gln Lys Leu Glu Arg Ile Gln Leu Thr Met Glu Ala Glu Leu Gly 
        115                 120                 125             

Gln Thr Ser Leu Glu Lys Val Val Ala Asp Ala Glu Ser Gln Met Lys 
    130                 135                 140                 

Asp 
145 

<210>   3359
<211>   846
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3359
atggatatga cgaaaatagc tcttctttca gatattcatg gaaataccac cgccttggag   60

gctgttttgg cagatgctcg gcagatagga gtggatgaat actggctttt gggagatatt   120
ctcatgccag ggacagggcg tagaaggatt ttggacttgt tggatcaact accgattacg   180
gctagagttt tgggaaactg ggaagacagt ctttggcatg gtgtccgtaa ggaattggac   240
agtactcgcc ccagtcaacg ctatctcttg cgccagtgcc agtatgtttt agaggaaatt   300
tccctagaag aaattgaagt gctccacaat caacctcttc aaattcatcg tcagtttggg   360
gatttgacgg tgggaattag ccatcatctg cctgataaga actgggggcg agagttgatt   420
catactggca aacaagagga gtttgaccgc ttggtgactc atcctccctg tgatattgct   480
gtttatggac atattcacca gcagttgctt cgttacggga ctggtgggca attgattgtc   540
aatccgggtt cgattggcca acctttcttt ttggacgctc agctacggaa ggacttgcgg   600
gcccagtata tgattttgga gtttgatgac aaaggcctgg tagatatgga cttccgacgg   660
gtagactacg atgtagcagc tgaattgcag ctggctaaag acctgagact tccctatttt   720
gaggtttact atgaaagtct ggtcaatggg atccaccata ctcatcatca ggaatttttg   780
agagaattgg ctcagaaaga gggctgcgat cgggagttag acgactggtt gaaaagtggt   840
aacgat                                                              846


<210>   3360
<211>   282
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903522 (e-168)

<400>   3360
Met Asp Met Thr Lys Ile Ala Leu Leu Ser Asp Ile His Gly Asn Thr 
1               5                   10                  15      

Thr Ala Leu Glu Ala Val Leu Ala Asp Ala Arg Gln Ile Gly Val Asp 
            20                  25                  30          

Glu Tyr Trp Leu Leu Gly Asp Ile Leu Met Pro Gly Thr Gly Arg Arg 
        35                  40                  45              

Arg Ile Leu Asp Leu Leu Asp Gln Leu Pro Ile Thr Ala Arg Val Leu 
    50                  55                  60                  

Gly Asn Trp Glu Asp Ser Leu Trp His Gly Val Arg Lys Glu Leu Asp 
65                  70                  75                  80  

Ser Thr Arg Pro Ser Gln Arg Tyr Leu Leu Arg Gln Cys Gln Tyr Val 
                85                  90                  95      

Leu Glu Glu Ile Ser Leu Glu Glu Ile Glu Val Leu His Asn Gln Pro 
            100                 105                 110         

Leu Gln Ile His Arg Gln Phe Gly Asp Leu Thr Val Gly Ile Ser His 
        115                 120                 125             

His Leu Pro Asp Lys Asn Trp Gly Arg Glu Leu Ile His Thr Gly Lys 
    130                 135                 140                 

Gln Glu Glu Phe Asp Arg Leu Val Thr His Pro Pro Cys Asp Ile Ala 
145                 150                 155                 160 

Val Tyr Gly His Ile His Gln Gln Leu Leu Arg Tyr Gly Thr Gly Gly 
                165                 170                 175     

Gln Leu Ile Val Asn Pro Gly Ser Ile Gly Gln Pro Phe Phe Leu Asp 
            180                 185                 190         

Ala Gln Leu Arg Lys Asp Leu Arg Ala Gln Tyr Met Ile Leu Glu Phe 
        195                 200                 205             

Asp Asp Lys Gly Leu Val Asp Met Asp Phe Arg Arg Val Asp Tyr Asp 
    210                 215                 220                 

Val Ala Ala Glu Leu Gln Leu Ala Lys Asp Leu Arg Leu Pro Tyr Phe 
225                 230                 235                 240 

Glu Val Tyr Tyr Glu Ser Leu Val Asn Gly Ile His His Thr His His 
                245                 250                 255     

Gln Glu Phe Leu Arg Glu Leu Ala Gln Lys Glu Gly Cys Asp Arg Glu 
            260                 265                 270         

Leu Asp Asp Trp Leu Lys Ser Gly Asn Asp 
        275                 280         

<210>   3361
<211>   648
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3361
atgaccccaa acaaagaaga ctatctaaaa tgtatttatg aaattggcat agacctgcat   60
aagattacca acaaggaaat tgcggctcgc atgcaagtct ctccccctgc cgtaactgaa   120
atgatcaaac gaatgaaaag tgaaaatctc atcctaaagg acaaggaatg tggctatcta   180
ctgactgacc tcggtctcaa actggtctct gagctctatc gtaagcaccg cttgattgaa   240
gtttttctag ttcatcattt agactataca agtgaccaga ttcacgagga agctgaggtc   300
ttggaacaca ctgtctctga cctgttcgtg gaaagactag ataaactgct aggtttccct   360
aaaacctgcc cccacggggg aactattcct gccaagggag aactactcgt tgaaatcaat   420
aacctcccac tagctgatat caaggaagct ggcgcctacc gcctgactcg ggtgcacgat   480
agttttgaca ttctccatta tctggacaag cactcacttc acatcggtga ccagctccaa   540
gtcaagcagt ttgatggctt cagcaatacc ttcactatcc tcagtaacga cgaggattta   600
caagtgaata tggacattgc aaaacaactc tatgtcgaga aaatcaac                648

<210>   3362
<211>   216
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron-dependent transcriptional regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903523 (e-123)

<400>   3362
Met Thr Pro Asn Lys Glu Asp Tyr Leu Lys Cys Ile Tyr Glu Ile Gly 
1               5                   10                  15      

Ile Asp Leu His Lys Ile Thr Asn Lys Glu Ile Ala Ala Arg Met Gln 
            20                  25                  30          

Val Ser Pro Pro Ala Val Thr Glu Met Ile Lys Arg Met Lys Ser Glu 
        35                  40                  45              

Asn Leu Ile Leu Lys Asp Lys Glu Cys Gly Tyr Leu Leu Thr Asp Leu 
    50                  55                  60                  

Gly Leu Lys Leu Val Ser Glu Leu Tyr Arg Lys His Arg Leu Ile Glu 
65                  70                  75                  80  

Val Phe Leu Val His His Leu Asp Tyr Thr Ser Asp Gln Ile His Glu 
                85                  90                  95      

Glu Ala Glu Val Leu Glu His Thr Val Ser Asp Leu Phe Val Glu Arg 
            100                 105                 110         

Leu Asp Lys Leu Leu Gly Phe Pro Lys Thr Cys Pro His Gly Gly Thr 
        115                 120                 125             

Ile Pro Ala Lys Gly Glu Leu Leu Val Glu Ile Asn Asn Leu Pro Leu 
    130                 135                 140                 

Ala Asp Ile Lys Glu Ala Gly Ala Tyr Arg Leu Thr Arg Val His Asp 
145                 150                 155                 160 

Ser Phe Asp Ile Leu His Tyr Leu Asp Lys His Ser Leu His Ile Gly 
                165                 170                 175     

Asp Gln Leu Gln Val Lys Gln Phe Asp Gly Phe Ser Asn Thr Phe Thr 
            180                 185                 190         

Ile Leu Ser Asn Asp Glu Asp Leu Gln Val Asn Met Asp Ile Ala Lys 
        195                 200                 205             

Gln Leu Tyr Val Glu Lys Ile Asn 
    210                 215     

<210>   3363
<211>   1272
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3363
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa catccagatt   60
ttagacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accttctaaa   180
attccttatc ttgaaacgac tggtatgcct actagaattc tccttagaaa gcgtcgattc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ctatcgtcaa gaagaatcac   300
caaatccctc gtatcatcaa ccaaaagatt gctcaaaagt taattgaaaa gatttctatg   360
actgatattg cccatcagct ttccatctca acttcaactg ttattcgtaa gctcaatgac   420
tttcacttta aacatgattt ttcttgtctt cctgagatta tgtcttggga tgagtatgct   480
tttacaaaag gaaagatgag cttcattgcg caagatttta acaatctcaa tatcatcaac   540
aatctcaata tcatcactgt tcttaaggga agaacacaag ctgtcatccg aaatcacttt   600
cttaaatatg atagagccgt ccgatgtcgc gtcaaaatca ttactatgga tatgtttagt   660
ccttactatg atttagctag acaacttttc ccgtgtgcta aaatcgtgtt ggatcgcttt   720
cacattgtac aacatcttag ccgtgctatg agtcgtgtgc gtgttcaaat catgaatcag   780
tttcatcgaa aatcccatga atacaaggct atcaagcgct actggaagct catacaacag   840
gatagccgta aactgagtga taagcgattt tatcgtccta cttttcgtat gcacttaacc   900
aataaagaga ttttagacaa gcttttgagc tattcacaag acttgaaaca ccactatcag   960
ctctatcaac tcttgctgtt tcactttcag aataagaaac cggagaaatt tttcggactc   1020
attgaggaca atctaaagca ggttcatcct atttttcaga ctgtctttaa aaccttcctc   1080
aaagataaag aaaagattgt caacgccctt caactacact attctaatgc caaactggaa   1140
gcgaccaata atctcatcaa acttatcaag cgcaatgcct ttggttttcg gaactttgaa   1200

aacttcaaaa aacggatttt tatcgctctg aatatcaaaa aagaaaggac aaaatttgtc   1260
ctttctcgag ct                                                       1272

<210>   3364
<211>   424
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903763 (0.E+01)

<400>   3364
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ser 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Lys 
    130                 135                 140                 

His Asp Phe Ser Cys Leu Pro Glu Ile Met Ser Trp Asp Glu Tyr Ala 
145                 150                 155                 160 

Phe Thr Lys Gly Lys Met Ser Phe Ile Ala Gln Asp Phe Asn Asn Leu 
                165                 170                 175     

Asn Ile Ile Asn Asn Leu Asn Ile Ile Thr Val Leu Lys Gly Arg Thr 
            180                 185                 190         

Gln Ala Val Ile Arg Asn His Phe Leu Lys Tyr Asp Arg Ala Val Arg 
        195                 200                 205             

Cys Arg Val Lys Ile Ile Thr Met Asp Met Phe Ser Pro Tyr Tyr Asp 
    210                 215                 220                 

Leu Ala Arg Gln Leu Phe Pro Cys Ala Lys Ile Val Leu Asp Arg Phe 
225                 230                 235                 240 

His Ile Val Gln His Leu Ser Arg Ala Met Ser Arg Val Arg Val Gln 
                245                 250                 255     

Ile Met Asn Gln Phe His Arg Lys Ser His Glu Tyr Lys Ala Ile Lys 
            260                 265                 270         

Arg Tyr Trp Lys Leu Ile Gln Gln Asp Ser Arg Lys Leu Ser Asp Lys 
        275                 280                 285             

Arg Phe Tyr Arg Pro Thr Phe Arg Met His Leu Thr Asn Lys Glu Ile 
    290                 295                 300                 

Leu Asp Lys Leu Leu Ser Tyr Ser Gln Asp Leu Lys His His Tyr Gln 
305                 310                 315                 320 

Leu Tyr Gln Leu Leu Leu Phe His Phe Gln Asn Lys Lys Pro Glu Lys 
                325                 330                 335     

Phe Phe Gly Leu Ile Glu Asp Asn Leu Lys Gln Val His Pro Ile Phe 
            340                 345                 350         

Gln Thr Val Phe Lys Thr Phe Leu Lys Asp Lys Glu Lys Ile Val Asn 
        355                 360                 365             

Ala Leu Gln Leu His Tyr Ser Asn Ala Lys Leu Glu Ala Thr Asn Asn 
    370                 375                 380                 

Leu Ile Lys Leu Ile Lys Arg Asn Ala Phe Gly Phe Arg Asn Phe Glu 
385                 390                 395                 400 

Asn Phe Lys Lys Arg Ile Phe Ile Ala Leu Asn Ile Lys Lys Glu Arg 
                405                 410                 415     

Thr Lys Phe Val Leu Ser Arg Ala 
            420                 

<210>   3365
<211>   519
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3365
atgttgtcca ctcgtttcac ggggaaatta agcaaatggg gaaattactt tggtattgtt   60
aataccattt tgtccggtgc tattgattat atccttggaa ataaggcggc catcattacc   120
tatcccgtca ccttcctcat ttataccttt gctataaaga agtgggaagc ttcgcaagaa   180
ggcagaccca accaaatgag ccaaaaacag gtaaaattgg cggccatcat catttccatc   240
atcgccttcc tctttgcctt tgtgaccaac tatatcggat atgggggcaa gatgaatctc   300
cttgcctacg taacaactat tgcctttgca ctgtccctca ttgccaatgc tttgaatgca   360
ttaaaactaa caactcagtg gggcttttgg ttgatttaca atttcgttca gctgacaaaa   420
gctggtattc aaggaaactt cgccaatatc ggtaaataca tcttttatat cctcaatgca   480
atcggagctt tatttgtctg gaatgatgaa gaagttaga                          519

<210>   3366
<211>   173
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903525 (2.E-63)

<400>   3366
Met Leu Ser Thr Arg Phe Thr Gly Lys Leu Ser Lys Trp Gly Asn Tyr 
1               5                   10                  15      

Phe Gly Ile Val Asn Thr Ile Leu Ser Gly Ala Ile Asp Tyr Ile Leu 
            20                  25                  30          

Gly Asn Lys Ala Ala Ile Ile Thr Tyr Pro Val Thr Phe Leu Ile Tyr 
        35                  40                  45              

Thr Phe Ala Ile Lys Lys Trp Glu Ala Ser Gln Glu Gly Arg Pro Asn 
    50                  55                  60                  

Gln Met Ser Gln Lys Gln Val Lys Leu Ala Ala Ile Ile Ile Ser Ile 
65                  70                  75                  80  

Ile Ala Phe Leu Phe Ala Phe Val Thr Asn Tyr Ile Gly Tyr Gly Gly 
                85                  90                  95      

Lys Met Asn Leu Leu Ala Tyr Val Thr Thr Ile Ala Phe Ala Leu Ser 
            100                 105                 110         

Leu Ile Ala Asn Ala Leu Asn Ala Leu Lys Leu Thr Thr Gln Trp Gly 
        115                 120                 125             

Phe Trp Leu Ile Tyr Asn Phe Val Gln Leu Thr Lys Ala Gly Ile Gln 
    130                 135                 140                 

Gly Asn Phe Ala Asn Ile Gly Lys Tyr Ile Phe Tyr Ile Leu Asn Ala 
145                 150                 155                 160 

Ile Gly Ala Leu Phe Val Trp Asn Asp Glu Glu Val Arg 
                165                 170             

<210>   3367
<211>   411
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3367
atgaaaaaac tctatagaat ccattttata gcaattgcag ttattgattt gctactattt   60
gcatttttta tcactagact cgagacatct tttgagtggc tcttgctctc tggtttaatt   120
ttcttccttg ctcaaggact cctgctattt ctcttggtcg tccgactcaa acatcaattc   180
gctgagattt atcctcaaat caataaaaag attcgcttct actatttagg ggttctcacc   240
attgattttc tattttttgt tctcttagcc ttcattagtt ctcagcgttt ttcatctctt   300
atgccaatca tcactgcttg ccattctact ttttattata tgacagctga ctacctaaga   360
gaaaactatc cagactttta cgacaaacac atctctttat gggagtgtct c            411

<210>   3368
<211>   137
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Feature of note: WYY motif; 1 transmembrane domain
<223>   Similar to strain R6 sequence 15903526 (1.E-72)

<400>   3368
Met Lys Lys Leu Tyr Arg Ile His Phe Ile Ala Ile Ala Val Ile Asp 
1               5                   10                  15      

Leu Leu Leu Phe Ala Phe Phe Ile Thr Arg Leu Glu Thr Ser Phe Glu 
            20                  25                  30          

Trp Leu Leu Leu Ser Gly Leu Ile Phe Phe Leu Ala Gln Gly Leu Leu 
        35                  40                  45              

Leu Phe Leu Leu Val Val Arg Leu Lys His Gln Phe Ala Glu Ile Tyr 
    50                  55                  60                  

Pro Gln Ile Asn Lys Lys Ile Arg Phe Tyr Tyr Leu Gly Val Leu Thr 
65                  70                  75                  80  

Ile Asp Phe Leu Phe Phe Val Leu Leu Ala Phe Ile Ser Ser Gln Arg 
                85                  90                  95      

Phe Ser Ser Leu Met Pro Ile Ile Thr Ala Cys His Ser Thr Phe Tyr 
            100                 105                 110         

Tyr Met Thr Ala Asp Tyr Leu Arg Glu Asn Tyr Pro Asp Phe Tyr Asp 
        115                 120                 125             

Lys His Ile Ser Leu Trp Glu Cys Leu 
    130                 135         

<210>   3369
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3369
atgaaagaaa atgagccaac cgctataaat caaaatccag tcccaagtaa gccccctttt   60
aaatgtcaaa aatgccagca tgattccatc aatgacaagg agttgaatgg ttttgatgaa   120
gatgattttt ttcatgctaa aacctccttt tctttagaga cactccca                168

<210>   3370
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3370
Met Lys Glu Asn Glu Pro Thr Ala Ile Asn Gln Asn Pro Val Pro Ser 
1               5                   10                  15      

Lys Pro Pro Phe Lys Cys Gln Lys Cys Gln His Asp Ser Ile Asn Asp 
            20                  25                  30          

Lys Glu Leu Asn Gly Phe Asp Glu Asp Asp Phe Phe His Ala Lys Thr 
        35                  40                  45              

Ser Phe Ser Leu Glu Thr Leu Pro 
    50                  55      

<210>   3371
<211>   183
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3371
atgaaaaaaa tcatcttcat caaaaccatt caactccttg tcattgatgg aatcatgctg   60
gcatttttga catttaaaag ggggcttact tgggactgga ttttgattta tagcggttgg   120
ctcattttct ttcatcctgt gctattgacc tatctttcaa accaactttg tgaccacttt   180
agt                                                                 183

<210>   3372
<211>   61
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903528 (4.E-12)

<400>   3372
Met Lys Lys Ile Ile Phe Ile Lys Thr Ile Gln Leu Leu Val Ile Asp 
1               5                   10                  15      

Gly Ile Met Leu Ala Phe Leu Thr Phe Lys Arg Gly Leu Thr Trp Asp 
            20                  25                  30          

Trp Ile Leu Ile Tyr Ser Gly Trp Leu Ile Phe Phe His Pro Val Leu 
        35                  40                  45              

Leu Thr Tyr Leu Ser Asn Gln Leu Cys Asp His Phe Ser 
    50                  55                  60      

<210>   3373
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3373
atgattctct ccttggtgtc tttaagtgat attccacttt tccttcaggg aactctcctc   60
atcctaggac atctcatccc ttcctatcgc atctgccaaa gcctgaaaag agacttcccc   120
caagcatatc aagaaccgat ttctttttgg agtatttta                          159

<210>   3374
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903528 (3.E-26)

<400>   3374
Met Ile Leu Ser Leu Val Ser Leu Ser Asp Ile Pro Leu Phe Leu Gln 
1               5                   10                  15      

Gly Thr Leu Leu Ile Leu Gly His Leu Ile Pro Ser Tyr Arg Ile Cys 
            20                  25                  30          

Gln Ser Leu Lys Arg Asp Phe Pro Gln Ala Tyr Gln Glu Pro Ile Ser 
        35                  40                  45              

Phe Trp Ser Ile Leu 
    50              

<210>   3375
<211>   441
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3375
atgaaaatca ttatccaacg ggttaaaaaa gcccaagtga gtatagaagg ccagattcag   60
ggaaaaatca atcagggact tttattgctg gttggtgttg gaccagagga ccaagaggaa   120
gatttggact atgctgtgag aaaactggtc aatatgcgga ttttttcaga cgcagaaggc   180
aagatgaacc tgtctgtcaa agatattgaa ggagaaatcc tctctatttc tcagtttacc   240
ctctttgcgg atactaagag aggcaatcgt ccagccttta caggggcagc taaacctgat   300
atggcatcag acttctatga tgctttcaat caaaaattag cgcaagaagt gcccgttcag   360
acaggcatct ttggagcaga tatgcaggtt gagctggtta ataatggacc tgttaccatt   420
atcctagata ctaaaaagag a                                             441

<210>   3376
<211>   147
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903529 (7.E-79)

<400>   3376
Met Lys Ile Ile Ile Gln Arg Val Lys Lys Ala Gln Val Ser Ile Glu 
1               5                   10                  15      

Gly Gln Ile Gln Gly Lys Ile Asn Gln Gly Leu Leu Leu Leu Val Gly 
            20                  25                  30          

Val Gly Pro Glu Asp Gln Glu Glu Asp Leu Asp Tyr Ala Val Arg Lys 
        35                  40                  45              

Leu Val Asn Met Arg Ile Phe Ser Asp Ala Glu Gly Lys Met Asn Leu 
    50                  55                  60                  

Ser Val Lys Asp Ile Glu Gly Glu Ile Leu Ser Ile Ser Gln Phe Thr 
65                  70                  75                  80  

Leu Phe Ala Asp Thr Lys Arg Gly Asn Arg Pro Ala Phe Thr Gly Ala 
                85                  90                  95      

Ala Lys Pro Asp Met Ala Ser Asp Phe Tyr Asp Ala Phe Asn Gln Lys 
            100                 105                 110         

Leu Ala Gln Glu Val Pro Val Gln Thr Gly Ile Phe Gly Ala Asp Met 
        115                 120                 125             

Gln Val Glu Leu Val Asn Asn Gly Pro Val Thr Ile Ile Leu Asp Thr 
    130                 135                 140                 

Lys Lys Arg 
145         

<210>   3377
<211>   2220
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3377
atgccgaaag aagtgaattt aacaggcgaa gaagttgtcg ctttaaccaa agaatattta   60
acggaagagg atgttcattt tgtccataag gccttggtct atgctgttga atgccacagt   120
ggtcaatatc gcaaatcagg cgagccttat atcattcacc ctatccaagt ggcaggtatt   180
ttagctaagc taaagctgga tgctgtaaca gtagcttgtg gattcttgca tgatgtggtg   240
gaagatacag atgcgacttt ggacgatttg gaaagagagt ttggtcctga tgtgcggatg   300
attgttgacg gagttaccaa gcttggcaag gtcgagtaca aatcgatcga ggagcaatta   360
gcggaaaatc atcgcaagat gctcatggcc atgtctgagg acatccgcgt tattttggtc   420
aaactgtctg accgcttgca caatatgcgg accctgaaac atcttcgaaa agacaagcag   480
gagcgtattt ccaaagaaac catggaaatc tatgccccgc ttgcccatcg tttggggatt   540
tccagtgtca aatgggaatt agaagacttg tctttccgtt atctcaatcc aacggagttt   600
tacaagatta cccatatgat gaaggaaaag cgcagggagc gtgaggcctt ggtggatgag   660
gtagtcacaa aattagagga gtatacgaca gaacgtcact tgaaagggaa gatttatggt   720
cgtcccaagc atatttactc aattttccgc aaaatgcagg acaagagaaa acggtttgag   780
gaaatctatg atctgattgc tattcgttgt attttagata cccaaagtga tgtttatgcc   840
atgcttggtt acgtgcatga attttggaaa ccgatgccag gtcgcttcaa agactatatc   900
gccaaccgca aggccaatgg ttatcagtct atccatacga ctgtttatgg accaaaaggg   960
ccgattgaat tccagattcg aaccaaggaa atgcacgagg tggctgagta cggggttgcg   1020
gctcactggg cttataagaa aggtataaag gggcaagtta acagcaagga atcagctatt   1080
ggaatgaact ggatcaagga gatgatggag ctccaagacc aggctgatga tgctaaggaa   1140
tttgtggact ctgttaagga aaactatttg gctgaggaga tttacgtttt taccccagat   1200
ggagctgtcc gttcccttcc caaagattca ggaccgattg attttgccta cgaaatccat   1260
accaaggtcg gtgaaaaagc aactggtgcc aaggtcaatg gccgcatggt tccactgaca   1320
accaagttaa agacagggga tcaggttgaa attatcgcca acccgaactc ctttggacct   1380
agccgtgact ggctcaatat ggtcaagact agcaaggcgc gcaataagat tcgccagttc   1440
tttaaaaacc aagataagga attgtctgtc aacaagggtc gtgagatgct gatggctcag   1500
ttccaagaaa atggctatgt ggcaaataaa tttatggaca agcgccacat ggatcaagtt   1560
ctgcaaaaga ccagttacaa gacagaagac tccctctttg cggccattgg ttttggggaa   1620
atcggtgcga ttaccgtctt taaccgtctg actgaaaagg aacgccgtga ggaagagcgt   1680
gccaaggcca aagctgaggc agaggagctt gtcaaaggtg gcgaggtcaa ggttgaaaat   1740
aaagaaaccc tcaaggtcaa gcatgagggg ggagtggtta ttgaaggtgc ttctggtctc   1800
ctagtgcgga ttgctaagtg ttgtaacccc gtgcctggtg acgatattgt tggctacatt   1860
accaagggtc gtggtgtggc tattcaccgt gtggactgta tgaacctgcg tgcccaagaa   1920
aactacgagc aacgtctcct tgatgtggaa tgggaagacc agtaccctag ctcaaataag   1980
gagtatatgg cccatatcga tatctacggt ctcaaccgta caggactgtt gaacgatgta   2040
ctgcaagttc tttcaaatac aaccaagaat atttcaacgg tcaatgccca accaaccaag   2100
gatatgaagt ttgctaatat ccatgtgtcc ttcggtattg ccaacctctc tacactgacc   2160
acggttgtcg ataaaattaa gagtgtgcca gaagtttact ctgtcaaacg gaccaacggc   2220

<210>   3378
<211>   740
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP pyrophosphokinase (relA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903530 (0.E+01)

<400>   3378
Met Pro Lys Glu Val Asn Leu Thr Gly Glu Glu Val Val Ala Leu Thr 
1               5                   10                  15      

Lys Glu Tyr Leu Thr Glu Glu Asp Val His Phe Val His Lys Ala Leu 
            20                  25                  30          

Val Tyr Ala Val Glu Cys His Ser Gly Gln Tyr Arg Lys Ser Gly Glu 
        35                  40                  45              

Pro Tyr Ile Ile His Pro Ile Gln Val Ala Gly Ile Leu Ala Lys Leu 
    50                  55                  60                  

Lys Leu Asp Ala Val Thr Val Ala Cys Gly Phe Leu His Asp Val Val 
65                  70                  75                  80  

Glu Asp Thr Asp Ala Thr Leu Asp Asp Leu Glu Arg Glu Phe Gly Pro 
                85                  90                  95      

Asp Val Arg Met Ile Val Asp Gly Val Thr Lys Leu Gly Lys Val Glu 
            100                 105                 110         

Tyr Lys Ser Ile Glu Glu Gln Leu Ala Glu Asn His Arg Lys Met Leu 
        115                 120                 125             

Met Ala Met Ser Glu Asp Ile Arg Val Ile Leu Val Lys Leu Ser Asp 
    130                 135                 140                 

Arg Leu His Asn Met Arg Thr Leu Lys His Leu Arg Lys Asp Lys Gln 
145                 150                 155                 160 

Glu Arg Ile Ser Lys Glu Thr Met Glu Ile Tyr Ala Pro Leu Ala His 
                165                 170                 175     

Arg Leu Gly Ile Ser Ser Val Lys Trp Glu Leu Glu Asp Leu Ser Phe 
            180                 185                 190         

Arg Tyr Leu Asn Pro Thr Glu Phe Tyr Lys Ile Thr His Met Met Lys 
        195                 200                 205             

Glu Lys Arg Arg Glu Arg Glu Ala Leu Val Asp Glu Val Val Thr Lys 
    210                 215                 220                 

Leu Glu Glu Tyr Thr Thr Glu Arg His Leu Lys Gly Lys Ile Tyr Gly 
225                 230                 235                 240 

Arg Pro Lys His Ile Tyr Ser Ile Phe Arg Lys Met Gln Asp Lys Arg 
                245                 250                 255     

Lys Arg Phe Glu Glu Ile Tyr Asp Leu Ile Ala Ile Arg Cys Ile Leu 
            260                 265                 270         

Asp Thr Gln Ser Asp Val Tyr Ala Met Leu Gly Tyr Val His Glu Phe 
        275                 280                 285             

Trp Lys Pro Met Pro Gly Arg Phe Lys Asp Tyr Ile Ala Asn Arg Lys 
    290                 295                 300                 

Ala Asn Gly Tyr Gln Ser Ile His Thr Thr Val Tyr Gly Pro Lys Gly 
305                 310                 315                 320 

Pro Ile Glu Phe Gln Ile Arg Thr Lys Glu Met His Glu Val Ala Glu 
                325                 330                 335     

Tyr Gly Val Ala Ala His Trp Ala Tyr Lys Lys Gly Ile Lys Gly Gln 
            340                 345                 350         

Val Asn Ser Lys Glu Ser Ala Ile Gly Met Asn Trp Ile Lys Glu Met 
        355                 360                 365             


Met Glu Leu Gln Asp Gln Ala Asp Asp Ala Lys Glu Phe Val Asp Ser 
    370                 375                 380                 

Val Lys Glu Asn Tyr Leu Ala Glu Glu Ile Tyr Val Phe Thr Pro Asp 
385                 390                 395                 400 

Gly Ala Val Arg Ser Leu Pro Lys Asp Ser Gly Pro Ile Asp Phe Ala 
                405                 410                 415     

Tyr Glu Ile His Thr Lys Val Gly Glu Lys Ala Thr Gly Ala Lys Val 
            420                 425                 430         

Asn Gly Arg Met Val Pro Leu Thr Thr Lys Leu Lys Thr Gly Asp Gln 
        435                 440                 445             

Val Glu Ile Ile Ala Asn Pro Asn Ser Phe Gly Pro Ser Arg Asp Trp 
    450                 455                 460                 

Leu Asn Met Val Lys Thr Ser Lys Ala Arg Asn Lys Ile Arg Gln Phe 
465                 470                 475                 480 

Phe Lys Asn Gln Asp Lys Glu Leu Ser Val Asn Lys Gly Arg Glu Met 
                485                 490                 495     

Leu Met Ala Gln Phe Gln Glu Asn Gly Tyr Val Ala Asn Lys Phe Met 
            500                 505                 510         

Asp Lys Arg His Met Asp Gln Val Leu Gln Lys Thr Ser Tyr Lys Thr 
        515                 520                 525             

Glu Asp Ser Leu Phe Ala Ala Ile Gly Phe Gly Glu Ile Gly Ala Ile 
    530                 535                 540                 

Thr Val Phe Asn Arg Leu Thr Glu Lys Glu Arg Arg Glu Glu Glu Arg 
545                 550                 555                 560 

Ala Lys Ala Lys Ala Glu Ala Glu Glu Leu Val Lys Gly Gly Glu Val 
                565                 570                 575     

Lys Val Glu Asn Lys Glu Thr Leu Lys Val Lys His Glu Gly Gly Val 
            580                 585                 590         

Val Ile Glu Gly Ala Ser Gly Leu Leu Val Arg Ile Ala Lys Cys Cys 
        595                 600                 605             

Asn Pro Val Pro Gly Asp Asp Ile Val Gly Tyr Ile Thr Lys Gly Arg 
    610                 615                 620                 

Gly Val Ala Ile His Arg Val Asp Cys Met Asn Leu Arg Ala Gln Glu 
625                 630                 635                 640 

Asn Tyr Glu Gln Arg Leu Leu Asp Val Glu Trp Glu Asp Gln Tyr Pro 
                645                 650                 655     

Ser Ser Asn Lys Glu Tyr Met Ala His Ile Asp Ile Tyr Gly Leu Asn 
            660                 665                 670         

Arg Thr Gly Leu Leu Asn Asp Val Leu Gln Val Leu Ser Asn Thr Thr 
        675                 680                 685             

Lys Asn Ile Ser Thr Val Asn Ala Gln Pro Thr Lys Asp Met Lys Phe 
    690                 695                 700                 


Ala Asn Ile His Val Ser Phe Gly Ile Ala Asn Leu Ser Thr Leu Thr 
705                 710                 715                 720 

Thr Val Val Asp Lys Ile Lys Ser Val Pro Glu Val Tyr Ser Val Lys 
                725                 730                 735     

Arg Thr Asn Gly 
            740 

<210>   3379
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3379
ttgctctttg attttcattt agtattaatt ccaaaatcca gtcaaggtac cagtgtatgt   60
gatacgagtt ccaccgttta tctttcgtat cttcaatgga attggggaag tcagaaagtc   120
tttgggttac aatatggttt ccgttcttct atctctcctt ctatcacc                168

<210>   3380
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3380
Met Leu Phe Asp Phe His Leu Val Leu Ile Pro Lys Ser Ser Gln Gly 
1               5                   10                  15      

Thr Ser Val Cys Asp Thr Ser Ser Thr Val Tyr Leu Ser Tyr Leu Gln 
            20                  25                  30          

Trp Asn Trp Gly Ser Gln Lys Val Phe Gly Leu Gln Tyr Gly Phe Arg 
        35                  40                  45              

Ser Ser Ile Ser Pro Ser Ile Thr 
    50                  55      

<210>   3381
<211>   183
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3381
ttgaggttgc agataaagtt gacgcggttt gaagagattt ttgaagagta taaaaatcct   60
caagatactt tcttctatcc tttagtttat aaggagaata cctatgaaaa aaactgctat   120
ttctatcttt gctctcctaa tgttaggagt ttgctgcctg ttcctattca gccagcaaag   180
cta                                                                 183

<210>   3382
<211>   61
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3382
Met Arg Leu Gln Ile Lys Leu Thr Arg Phe Glu Glu Ile Phe Glu Glu 
1               5                   10                  15      

Tyr Lys Asn Pro Gln Asp Thr Phe Phe Tyr Pro Leu Val Tyr Lys Glu 
            20                  25                  30          

Asn Thr Tyr Glu Lys Asn Cys Tyr Phe Tyr Leu Cys Ser Pro Asn Val 
        35                  40                  45              

Arg Ser Leu Leu Pro Val Pro Ile Gln Pro Ala Lys Leu 
    50                  55                  60      

<210>   3383
<211>   678
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3383
ttgaagagat tttcgaagag tattagtaca ttctttgaga ttggagctag tatgaaaatc   60
cataaaaccg tgaatcctgt tgcctatgaa aatacctatt atctagaagg cgaaaagcac   120
ctcatcgtcg tcgatcctgg tagtcattgg gaagccattc gtcagacaat cgagaagatc   180
aacaaaccga tctgtgctat tctcttgacc cacgcccatt atgaccatat catgagtctg   240
gacttggttc gcgagacgtt tggcaatcct cctgtctata tcgcagagag cgaagccagc   300
tggctctaca ctcctgtcga taatctctcc ggtctccctc gccacgatga tatggcagat   360
gtggtcacaa aacctgcaga acacaccttt gtctttcacg aagaatacca actagaggaa   420
tttcgtttta aggttctacc gaccccaggg cactctatcg gtggtgtttc cctagtcttt   480
cctgatgctc atctagtctt gacgggagat gctctattcc gcgaaactat cggacggacc   540
gaccttccga ctggtagcat ggagcaactc cttcatagta tccagaccca actcttcacc   600
ctaccaaact acgatgtcta tccaggacat ggtccagcta ctactatcgc tcacgaaaag   660
gccttcaatc cctttttc                                                 678

<210>   3384
<211>   226
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   metallo-beta-lactamase superfamily protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903533 (e-122)

<400>   3384
Met Lys Arg Phe Ser Lys Ser Ile Ser Thr Phe Phe Glu Ile Gly Ala 
1               5                   10                  15      

Ser Met Lys Ile His Lys Thr Val Asn Pro Val Ala Tyr Glu Asn Thr 
            20                  25                  30          

Tyr Tyr Leu Glu Gly Glu Lys His Leu Ile Val Val Asp Pro Gly Ser 
        35                  40                  45              

His Trp Glu Ala Ile Arg Gln Thr Ile Glu Lys Ile Asn Lys Pro Ile 
    50                  55                  60                  

Cys Ala Ile Leu Leu Thr His Ala His Tyr Asp His Ile Met Ser Leu 
65                  70                  75                  80  

Asp Leu Val Arg Glu Thr Phe Gly Asn Pro Pro Val Tyr Ile Ala Glu 
                85                  90                  95      

Ser Glu Ala Ser Trp Leu Tyr Thr Pro Val Asp Asn Leu Ser Gly Leu 
            100                 105                 110         

Pro Arg His Asp Asp Met Ala Asp Val Val Thr Lys Pro Ala Glu His 
        115                 120                 125             

Thr Phe Val Phe His Glu Glu Tyr Gln Leu Glu Glu Phe Arg Phe Lys 
    130                 135                 140                 

Val Leu Pro Thr Pro Gly His Ser Ile Gly Gly Val Ser Leu Val Phe 
145                 150                 155                 160 

Pro Asp Ala His Leu Val Leu Thr Gly Asp Ala Leu Phe Arg Glu Thr 
                165                 170                 175     

Ile Gly Arg Thr Asp Leu Pro Thr Gly Ser Met Glu Gln Leu Leu His 
            180                 185                 190         

Ser Ile Gln Thr Gln Leu Phe Thr Leu Pro Asn Tyr Asp Val Tyr Pro 
        195                 200                 205             

Gly His Gly Pro Ala Thr Thr Ile Ala His Glu Lys Ala Phe Asn Pro 
    210                 215                 220                 

Phe Phe 
225     

<210>   3385
<211>   1950
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3385
ttgcattccc tagtgatttt tgttaagata aatgcaaata caaatgaaag cgagaacaag   60
atgacacgtt atcaagatga tttttatgat gctatcaatg gagaatggca acagacagct   120
gaaatcccag cagataagtc tcaaacagga ggttttgttg atttagacca ggaaattgaa   180
gacctgatgc tggcgacaac agacaagtgg ttagcaggtg aagaagtgcc tgaggatgct   240
atcttggaaa actttgtcaa ataccaccgc ctagttcgtg attttgacaa gagagaagct   300
gacggtatca cacctgtctt accactcctt aaagaattcc aagaattgga gacttttgcg   360
gattttacag ctaaactagc agagtttgag cttgcaggaa aaccaaactt ccttcctttt   420
ggtgtatcgc cagactttat ggatgctaga atcaatgttc tatgggctag cgctccaagc   480
acaatcttgc cagatacgac ctactatgca gaagaacatc ctcagcgcga agagctcttg   540
actctttgga aagaaagcag cgcaaatctc ctcaaggctt atgatttctc tgatgaagaa   600
attgaagact tgctagaaaa aagacttgaa ttggaccgcc gagttgcggc agtggtgctc   660
tctaatgaag aaagttcaga atatgctaaa ctctatcatc catattctta cgaagatttc   720
aagaaattcg cgcctgccct acctttggat gacttcttca aagcagttat tgggcaatta   780
ccagacaagg ttattgtaga cgaggaacgt ttctggcaag cagcagagca attctacagt   840
gaggaagcct ggtctctcct taaagcaacc ttgattttga gtgttgtcaa tctttcaacc   900
agctatttaa cagaggatat ccgtgttttg tctggtgcct acagccgtgc cctttctgga   960
gttccagagg caaaagataa ggtcaaagca gcttatcatc tagcacaaga acctttcaag   1020
caagccctgg gtctttggta cgcccgtgag aagttctctc cagaagccaa ggcggatgtg   1080
gagaaaaaag tggcaaccat gattgatgtt tataaggagc gtctgcttaa gaatgactgg   1140
ctcactccag aaacctgtaa acaggctatc gtgaagctca atgtgatcaa accttatatt   1200
ggctatccag aagaattgcc tgcacgttac aaggataagg tagtgaatga aactgccagt   1260
ctttttgaga atgctctagc ctttgcgcgt gtggaaatca agcacagttg gagtaagtgg   1320
aaccagcctg tagattataa ggaatggggc atgcctgctc atatggtcaa tgcctactac   1380
aatcctcaga agaacctgat tgtctttcca gcggccattt tacaggcgcc tttctatgac   1440
ttgcatcagt catcttctgc taactacggt ggtattgggg cagtgattgc ccatgaaatt   1500
tcccacgcct ttgatactaa cggggcttcc tttgacgaaa atggtagcct caaggattgg   1560
tggacagaga gcgactatgc tgccttcaag gagaaaacac aaaaagtcat tgaccaattt   1620
gatggacagg attcttatgg agcaaccatt aacggtaaat tgactgtatc agaaaacgtg   1680
gctgacttgg gaggaatcgc agcagcgctt gaagcagcta agagagaagc agacttctca   1740
gcagaagagt tcttctacaa cttcggtcgc atctggcgca tgaaaggtcg accagaattt   1800
atgaaacttt tggctagcgt cgatgtgcac gcaccagcca aactccgtgt caatgtgcaa   1860
gtaccaaact tcgacgattt ctttacaacc tatgatgtca aagaaggaga cggaatgtgg   1920
cgttcaccag aggagcgcgt gattatttgg                                    1950

<210>   3386
<211>   650
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   endopeptidase O (pepO)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903534 (0.E+01)

<400>   3386
Met His Ser Leu Val Ile Phe Val Lys Ile Asn Ala Asn Thr Asn Glu 
1               5                   10                  15      

Ser Glu Asn Lys Met Thr Arg Tyr Gln Asp Asp Phe Tyr Asp Ala Ile 
            20                  25                  30          

Asn Gly Glu Trp Gln Gln Thr Ala Glu Ile Pro Ala Asp Lys Ser Gln 
        35                  40                  45              

Thr Gly Gly Phe Val Asp Leu Asp Gln Glu Ile Glu Asp Leu Met Leu 
    50                  55                  60                  

Ala Thr Thr Asp Lys Trp Leu Ala Gly Glu Glu Val Pro Glu Asp Ala 
65                  70                  75                  80  

Ile Leu Glu Asn Phe Val Lys Tyr His Arg Leu Val Arg Asp Phe Asp 
                85                  90                  95      

Lys Arg Glu Ala Asp Gly Ile Thr Pro Val Leu Pro Leu Leu Lys Glu 
            100                 105                 110         

Phe Gln Glu Leu Glu Thr Phe Ala Asp Phe Thr Ala Lys Leu Ala Glu 
        115                 120                 125             

Phe Glu Leu Ala Gly Lys Pro Asn Phe Leu Pro Phe Gly Val Ser Pro 
    130                 135                 140                 

Asp Phe Met Asp Ala Arg Ile Asn Val Leu Trp Ala Ser Ala Pro Ser 
145                 150                 155                 160 

Thr Ile Leu Pro Asp Thr Thr Tyr Tyr Ala Glu Glu His Pro Gln Arg 
                165                 170                 175     

Glu Glu Leu Leu Thr Leu Trp Lys Glu Ser Ser Ala Asn Leu Leu Lys 
            180                 185                 190         

Ala Tyr Asp Phe Ser Asp Glu Glu Ile Glu Asp Leu Leu Glu Lys Arg 
        195                 200                 205             

Leu Glu Leu Asp Arg Arg Val Ala Ala Val Val Leu Ser Asn Glu Glu 
    210                 215                 220                 

Ser Ser Glu Tyr Ala Lys Leu Tyr His Pro Tyr Ser Tyr Glu Asp Phe 
225                 230                 235                 240 

Lys Lys Phe Ala Pro Ala Leu Pro Leu Asp Asp Phe Phe Lys Ala Val 
                245                 250                 255     

Ile Gly Gln Leu Pro Asp Lys Val Ile Val Asp Glu Glu Arg Phe Trp 
            260                 265                 270         

Gln Ala Ala Glu Gln Phe Tyr Ser Glu Glu Ala Trp Ser Leu Leu Lys 
        275                 280                 285             

Ala Thr Leu Ile Leu Ser Val Val Asn Leu Ser Thr Ser Tyr Leu Thr 
    290                 295                 300                 

Glu Asp Ile Arg Val Leu Ser Gly Ala Tyr Ser Arg Ala Leu Ser Gly 
305                 310                 315                 320 

Val Pro Glu Ala Lys Asp Lys Val Lys Ala Ala Tyr His Leu Ala Gln 
                325                 330                 335     

Glu Pro Phe Lys Gln Ala Leu Gly Leu Trp Tyr Ala Arg Glu Lys Phe 
            340                 345                 350         

Ser Pro Glu Ala Lys Ala Asp Val Glu Lys Lys Val Ala Thr Met Ile 
        355                 360                 365             

Asp Val Tyr Lys Glu Arg Leu Leu Lys Asn Asp Trp Leu Thr Pro Glu 
    370                 375                 380                 

Thr Cys Lys Gln Ala Ile Val Lys Leu Asn Val Ile Lys Pro Tyr Ile 
385                 390                 395                 400 

Gly Tyr Pro Glu Glu Leu Pro Ala Arg Tyr Lys Asp Lys Val Val Asn 
                405                 410                 415     

Glu Thr Ala Ser Leu Phe Glu Asn Ala Leu Ala Phe Ala Arg Val Glu 
            420                 425                 430         

Ile Lys His Ser Trp Ser Lys Trp Asn Gln Pro Val Asp Tyr Lys Glu 
        435                 440                 445             

Trp Gly Met Pro Ala His Met Val Asn Ala Tyr Tyr Asn Pro Gln Lys 
    450                 455                 460                 

Asn Leu Ile Val Phe Pro Ala Ala Ile Leu Gln Ala Pro Phe Tyr Asp 
465                 470                 475                 480 

Leu His Gln Ser Ser Ser Ala Asn Tyr Gly Gly Ile Gly Ala Val Ile 
                485                 490                 495     

Ala His Glu Ile Ser His Ala Phe Asp Thr Asn Gly Ala Ser Phe Asp 
            500                 505                 510         

Glu Asn Gly Ser Leu Lys Asp Trp Trp Thr Glu Ser Asp Tyr Ala Ala 
        515                 520                 525             

Phe Lys Glu Lys Thr Gln Lys Val Ile Asp Gln Phe Asp Gly Gln Asp 
    530                 535                 540                 

Ser Tyr Gly Ala Thr Ile Asn Gly Lys Leu Thr Val Ser Glu Asn Val 
545                 550                 555                 560 

Ala Asp Leu Gly Gly Ile Ala Ala Ala Leu Glu Ala Ala Lys Arg Glu 
                565                 570                 575     

Ala Asp Phe Ser Ala Glu Glu Phe Phe Tyr Asn Phe Gly Arg Ile Trp 
            580                 585                 590         

Arg Met Lys Gly Arg Pro Glu Phe Met Lys Leu Leu Ala Ser Val Asp 
        595                 600                 605             

Val His Ala Pro Ala Lys Leu Arg Val Asn Val Gln Val Pro Asn Phe 
    610                 615                 620                 

Asp Asp Phe Phe Thr Thr Tyr Asp Val Lys Glu Gly Asp Gly Met Trp 
625                 630                 635                 640 

Arg Ser Pro Glu Glu Arg Val Ile Ile Trp 
                645                 650 

<210>   3387
<211>   720
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3387
atgatacgta tcgaaaacct cagtgtctcc tacaaagaaa cgttggcact taaggatatt   60
tcactagtgc tccatggacc aacaattacc ggcatcattg gtccaaacgg cgctgggaaa   120
tcaacactat taaaaggtat gttgggaatt atcccacatc aaggtcaggc atttctcgat   180
gacaaggaag ttaaaaaatc cttacaccga attgcctatg tcgaacaaaa aatcaatatc   240
gactacaact ttcccatcaa ggtcaaggaa tgcgtctcgt taggactatt tccctctatt   300
cctctctttc gaagtttaaa ggctaaacat tggaagaaag tgcaagaggc ccttgaaatc   360
gtcggcctag ctgactacgc tgaacgtcaa attagtcaac tgtctggagg tcaattccag   420
cgggtcttga ttgccagatg tttggtgcag gaagccgact atatcctctt ggatgaaccc   480
tttgctggga ttgactctgt cagtgaggaa atcatcatga atacgctgag agatttgaaa   540
aaagctggga agacggttct catcgttcac cacgacctca gcaagattcc ccactacttc   600
gatcaagtct tacttgtcaa tcgagaagtg attgcctttg gtccaacaaa agaaactttt   660
accgaaacca atctaaaaga agcttacggt aatcaactct ttttcaatgg aggtgaccta   720

<210>   3388
<211>   240
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   manganese ABC transporter, ATP-binding protein (psaB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903535 (e-135)

<400>   3388
Met Ile Arg Ile Glu Asn Leu Ser Val Ser Tyr Lys Glu Thr Leu Ala 
1               5                   10                  15      

Leu Lys Asp Ile Ser Leu Val Leu His Gly Pro Thr Ile Thr Gly Ile 
            20                  25                  30          

Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu Leu Lys Gly Met Leu 
        35                  40                  45              

Gly Ile Ile Pro His Gln Gly Gln Ala Phe Leu Asp Asp Lys Glu Val 
    50                  55                  60                  

Lys Lys Ser Leu His Arg Ile Ala Tyr Val Glu Gln Lys Ile Asn Ile 
65                  70                  75                  80  

Asp Tyr Asn Phe Pro Ile Lys Val Lys Glu Cys Val Ser Leu Gly Leu 
                85                  90                  95      

Phe Pro Ser Ile Pro Leu Phe Arg Ser Leu Lys Ala Lys His Trp Lys 
            100                 105                 110         

Lys Val Gln Glu Ala Leu Glu Ile Val Gly Leu Ala Asp Tyr Ala Glu 
        115                 120                 125             

Arg Gln Ile Ser Gln Leu Ser Gly Gly Gln Phe Gln Arg Val Leu Ile 
    130                 135                 140                 

Ala Arg Cys Leu Val Gln Glu Ala Asp Tyr Ile Leu Leu Asp Glu Pro 
145                 150                 155                 160 

Phe Ala Gly Ile Asp Ser Val Ser Glu Glu Ile Ile Met Asn Thr Leu 
                165                 170                 175     

Arg Asp Leu Lys Lys Ala Gly Lys Thr Val Leu Ile Val His His Asp 
            180                 185                 190         

Leu Ser Lys Ile Pro His Tyr Phe Asp Gln Val Leu Leu Val Asn Arg 
        195                 200                 205             

Glu Val Ile Ala Phe Gly Pro Thr Lys Glu Thr Phe Thr Glu Thr Asn 
    210                 215                 220                 

Leu Lys Glu Ala Tyr Gly Asn Gln Leu Phe Phe Asn Gly Gly Asp Leu 
225                 230                 235                 240 


<210>   3389
<211>   846
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3389
atgattgcag aatttatcga tggattgcaa aaattccatt tcctacaaaa tgccttgata   60
acagctattg tcgtcgggat tgtagctgga gctgtgggat gtttcattat tctacgcggg   120
atgtcactca tgggagatgc catttcacat gctgtcttac caggtgtagc cctatccttc   180
atcttgggcc ttgacttctt tatcggagcc attgtctttg gattgctagc tgccatcatc   240
attacctaca tcaaaggaaa ctcgattatc aaaagcgata ccgccatcgg cattaccttt   300
tcttctttct tagccctcgg tatcatcttg attggtgtcg ctaaaagttc aactgacctt   360
ttccatatcc tttttggtaa tatcctggcc gtccaagata cggatatgtt tattactatg   420
ggtgtggggg cagctatcct cttgttaatc tggattttct tcaagcaact cttgataact   480
tcctttgatg aactcttggc taaagccatg ggaatgcctg tcaatttcta tcactacctt   540
ctcatggtac tcctgactct cgtgtctgtg acagccatgc aaagtgtcgg aactatcctg   600
attgtagcca tgctgattac cccagctgca actgcttatc tgtatgctaa tagtctgaaa   660
agtatgattt tcctttcctc aaccttcgga gctactgctt cagttttggg actctttatt   720
ggctatagtt ttaatgttgc ggcaggttct agtatcgtgc ttacagctgc tagtttcttt   780
ctcattagct tctttatcgc tcccaaacaa cgatatttga aactgaaaaa taaacatttg   840
ttaaaa                                                              846

<210>   3390
<211>   282
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   manganese ABC transporter, permease protein, putative FRAMESHIFT (psaC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903536 (e-152)

<400>   3390
Met Ile Ala Glu Phe Ile Asp Gly Leu Gln Lys Phe His Phe Leu Gln 
1               5                   10                  15      

Asn Ala Leu Ile Thr Ala Ile Val Val Gly Ile Val Ala Gly Ala Val 
            20                  25                  30          

Gly Cys Phe Ile Ile Leu Arg Gly Met Ser Leu Met Gly Asp Ala Ile 
        35                  40                  45              

Ser His Ala Val Leu Pro Gly Val Ala Leu Ser Phe Ile Leu Gly Leu 
    50                  55                  60                  

Asp Phe Phe Ile Gly Ala Ile Val Phe Gly Leu Leu Ala Ala Ile Ile 
65                  70                  75                  80  

Ile Thr Tyr Ile Lys Gly Asn Ser Ile Ile Lys Ser Asp Thr Ala Ile 
                85                  90                  95      

Gly Ile Thr Phe Ser Ser Phe Leu Ala Leu Gly Ile Ile Leu Ile Gly 
            100                 105                 110         

Val Ala Lys Ser Ser Thr Asp Leu Phe His Ile Leu Phe Gly Asn Ile 
        115                 120                 125             

Leu Ala Val Gln Asp Thr Asp Met Phe Ile Thr Met Gly Val Gly Ala 
    130                 135                 140                 

Ala Ile Leu Leu Leu Ile Trp Ile Phe Phe Lys Gln Leu Leu Ile Thr 
145                 150                 155                 160 

Ser Phe Asp Glu Leu Leu Ala Lys Ala Met Gly Met Pro Val Asn Phe 
                165                 170                 175     

Tyr His Tyr Leu Leu Met Val Leu Leu Thr Leu Val Ser Val Thr Ala 
            180                 185                 190         

Met Gln Ser Val Gly Thr Ile Leu Ile Val Ala Met Leu Ile Thr Pro 
        195                 200                 205             

Ala Ala Thr Ala Tyr Leu Tyr Ala Asn Ser Leu Lys Ser Met Ile Phe 
    210                 215                 220                 

Leu Ser Ser Thr Phe Gly Ala Thr Ala Ser Val Leu Gly Leu Phe Ile 
225                 230                 235                 240 

Gly Tyr Ser Phe Asn Val Ala Ala Gly Ser Ser Ile Val Leu Thr Ala 
                245                 250                 255     

Ala Ser Phe Phe Leu Ile Ser Phe Phe Ile Ala Pro Lys Gln Arg Tyr 
            260                 265                 270         

Leu Lys Leu Lys Asn Lys His Leu Leu Lys 
        275                 280         

<210>   3391
<211>   927
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3391
atgaaaaaat taggtacatt actcgttctc tttctttctg caatcattct tgtagcatgt   60
gctagcggaa aaaaagatac aacttctggt caaaaactaa aagttgttgc tacaaactca   120
atcatcgctg atattactaa aaatattgct ggtgacaaaa ttgaccttca tagtatcgtt   180
ccgattgggc aagacccaca cgaatacgaa ccacttcctg aagacgttaa gaaaacttct   240
gaggctaatt tgattttcta taacggtatc aaccttgaaa caggtggcaa tgcttggttt   300
acaaaattgg tagaaaatgc caagaaaact gaaaacaaag actacttcgc agtcagcgac   360
ggcgttgatg ttatctacct tgaaggtcaa aatgaaaaag gaaaagaaga cccacacgct   420
tggcttaacc ttgaaaacgg tattattttt gctaaaaata tcgccaaaca attgagcgcc   480
aaagacccta acaataaaga attctatgaa aaaaatctca aagaatatac tgataagtta   540
gacaaacttg ataaagaaag taaggataaa tttaataaga tccctgctga aaagaaactc   600
attgtaacca gcgaaggagc attcaaatac ttctctaaag cctatggtgt cccaagtgct   660
tacatctggg aaatcaatac tgaagaagaa ggaactcctg aacaaatcaa gaccttggtt   720
gaaaaacttc gccaaacaaa agttccatca ctctttgtag aatcaagtgt ggatgaccgt   780
ccaatgaaaa ctgtttctca agacacaaac atcccaatct acgctcaaat ctttactgac   840
tctatcgcag aacaaggtaa agaaggcgac agctactaca gcatgatgaa atacaacctt   900
gacaagattg ctgaaggatt ggcaaaa                                       927

<210>   3392
<211>   309
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   manganese ABC transporter, manganese-binding adhesion liprotein (psaA)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903537 (e-177)

<400>   3392
Met Lys Lys Leu Gly Thr Leu Leu Val Leu Phe Leu Ser Ala Ile Ile 
1               5                   10                  15      

Leu Val Ala Cys Ala Ser Gly Lys Lys Asp Thr Thr Ser Gly Gln Lys 
            20                  25                  30          

Leu Lys Val Val Ala Thr Asn Ser Ile Ile Ala Asp Ile Thr Lys Asn 
        35                  40                  45              

Ile Ala Gly Asp Lys Ile Asp Leu His Ser Ile Val Pro Ile Gly Gln 
    50                  55                  60                  

Asp Pro His Glu Tyr Glu Pro Leu Pro Glu Asp Val Lys Lys Thr Ser 
65                  70                  75                  80  

Glu Ala Asn Leu Ile Phe Tyr Asn Gly Ile Asn Leu Glu Thr Gly Gly 
                85                  90                  95      

Asn Ala Trp Phe Thr Lys Leu Val Glu Asn Ala Lys Lys Thr Glu Asn 
            100                 105                 110         

Lys Asp Tyr Phe Ala Val Ser Asp Gly Val Asp Val Ile Tyr Leu Glu 
        115                 120                 125             

Gly Gln Asn Glu Lys Gly Lys Glu Asp Pro His Ala Trp Leu Asn Leu 
    130                 135                 140                 

Glu Asn Gly Ile Ile Phe Ala Lys Asn Ile Ala Lys Gln Leu Ser Ala 
145                 150                 155                 160 

Lys Asp Pro Asn Asn Lys Glu Phe Tyr Glu Lys Asn Leu Lys Glu Tyr 
                165                 170                 175     

Thr Asp Lys Leu Asp Lys Leu Asp Lys Glu Ser Lys Asp Lys Phe Asn 
            180                 185                 190         

Lys Ile Pro Ala Glu Lys Lys Leu Ile Val Thr Ser Glu Gly Ala Phe 
        195                 200                 205             

Lys Tyr Phe Ser Lys Ala Tyr Gly Val Pro Ser Ala Tyr Ile Trp Glu 
    210                 215                 220                 

Ile Asn Thr Glu Glu Glu Gly Thr Pro Glu Gln Ile Lys Thr Leu Val 
225                 230                 235                 240 

Glu Lys Leu Arg Gln Thr Lys Val Pro Ser Leu Phe Val Glu Ser Ser 
                245                 250                 255     

Val Asp Asp Arg Pro Met Lys Thr Val Ser Gln Asp Thr Asn Ile Pro 
            260                 265                 270         

Ile Tyr Ala Gln Ile Phe Thr Asp Ser Ile Ala Glu Gln Gly Lys Glu 
        275                 280                 285             

Gly Asp Ser Tyr Tyr Ser Met Met Lys Tyr Asn Leu Asp Lys Ile Ala 
    290                 295                 300                 

Glu Gly Leu Ala Lys 
305                 

<210>   3393
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3393
atgagctggc gttttttcta tgcccatatt tccggtcaaa tcattggaaa attccgactg   60
tttcagctaa aatggaagaa aaaagattgg agtatcctat gg                      102

<210>   3394
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3394
Met Ser Trp Arg Phe Phe Tyr Ala His Ile Ser Gly Gln Ile Ile Gly 
1               5                   10                  15      

Lys Phe Arg Leu Phe Gln Leu Lys Trp Lys Lys Lys Asp Trp Ser Ile 
            20                  25                  30          

Leu Trp 
        

<210>   3395
<211>   501
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3395
ttggagtatc ctatggtaac ttttctcgga aatcctgtga gctttacagg taaacaacta   60
caagtcggcg acaaggcgct tgatttttct cttactacaa cagatctttc taaaaaatct   120
ctggctgatt ttgatggcaa gaaaaaagtc ttgagtgtcg ttccttctat cgatacaggc   180
atctgctcaa ctcaaacacg tcgttttaat gaagaattgg ctggactgga caacacggtc   240
gtattgactg tttcaatgga cctacctttt gctcaaaaac gttggtgcgg tgctgaaggc   300
cttgacaatg ccattatgct ttcagactac tttgaccatt ctttcgggcg cgattatgcc   360
ctcttgatca acgaatggca cctattagca cgcgcagtct ttgtcctcga tactgacaat   420
acgattcgct acgttgaata cgtggataat atcaattctg agccaaactt cgaagccgca   480
attgcagctg ctaaagccct a                                             501

<210>   3396
<211>   167
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thiol peroxidase (psaD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903538 (1.E-96)

<400>   3396
Met Glu Tyr Pro Met Val Thr Phe Leu Gly Asn Pro Val Ser Phe Thr 
1               5                   10                  15      

Gly Lys Gln Leu Gln Val Gly Asp Lys Ala Leu Asp Phe Ser Leu Thr 
            20                  25                  30          

Thr Thr Asp Leu Ser Lys Lys Ser Leu Ala Asp Phe Asp Gly Lys Lys 
        35                  40                  45              

Lys Val Leu Ser Val Val Pro Ser Ile Asp Thr Gly Ile Cys Ser Thr 
    50                  55                  60                  

Gln Thr Arg Arg Phe Asn Glu Glu Leu Ala Gly Leu Asp Asn Thr Val 
65                  70                  75                  80  

Val Leu Thr Val Ser Met Asp Leu Pro Phe Ala Gln Lys Arg Trp Cys 
                85                  90                  95      

Gly Ala Glu Gly Leu Asp Asn Ala Ile Met Leu Ser Asp Tyr Phe Asp 
            100                 105                 110         

His Ser Phe Gly Arg Asp Tyr Ala Leu Leu Ile Asn Glu Trp His Leu 
        115                 120                 125             

Leu Ala Arg Ala Val Phe Val Leu Asp Thr Asp Asn Thr Ile Arg Tyr 
    130                 135                 140                 

Val Glu Tyr Val Asp Asn Ile Asn Ser Glu Pro Asn Phe Glu Ala Ala 
145                 150                 155                 160 

Ile Ala Ala Ala Lys Ala Leu 
                165         

<210>   3397
<211>   2772
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3397
atgccagtgt caaggatgtg gtgctcaacc agcatcctca ggatattgac agtttggagt   60
actagcatga tcaagcgaaa aacttattgg aaggacttag ttcagtcctt cacaggctcc   120
aaggggcgtt ttttatccat cttgatcctg atgatgttgg gatctctagc cttagtaggc   180
ctcaaagtaa ccagtcccaa catggaggcg acagctaatg cttatttaac aactgctcaa   240
accttggatt tggcagtcat gtctaactat ggcttggatc aagcagacca agaagaacta   300
aaacagacgg agggcgcaga ggtcgagttt ggctatttga cagatgtgac tatggataat   360
gggcaggatg ccattcggct gtactccaaa ccagagcgaa tttcaacctt tcagctaaga   420
aagggacgac ttcctcagtc agacaaggaa atcgctttgg ccactcattt gcaaggccaa   480
tacagcgtgg gacaggagat tagttttaaa gaaaaagaag agggtcattc ctctttaaaa   540
gaccatactt ataccattac tggttttgtg gattcggctg aaatcctctc ccagcgagat   600
atgggctacg caggaagtgg aagtgggact ctgacagcct atggggtgat tttacctagt   660
caatttgatc agaaagtcta caatatagct cgtttgaaat atcaagattt agcgggttta   720
aatgcctttt catcagctta tgaagaaaaa tccaagcaac atcaagaaga gcttgaacaa   780
attttatcag ataatggcaa ggtacgtctg caacttttga aaaaagaagg acaagagtct   840
ctagacaagg ggcaagagac ccttgacaag gctcagacta atttgcagga aggcaagcgt   900
cgtttagcag ctgctcaagc tcgtatacag gctcaagaaa gtcaactagc cttgtttcct   960
caagttcaga gagagcaggc tagtgctcaa cttacccaag ccaagcagga attgggcaag   1020
gaagaggaca aactaaagca agctgaacaa aatctagccc aagaaaagga aaaattagaa   1080
aaacatcagc aagtcttgga tgatttggcg gagccaaggt atcaggttta taatcgtcag   1140
accatgccag gtggtcaggg ctatcttatg tatagcaatg cttcatccag tattcgagca   1200
gtgggcaata tctttcctgt ggtactttat gccgtagcag ccatggtgac ctttacgacc   1260
atgactcgct ttgtagacga agagcgaact catgcaggga tttttaaggc cttgggttat   1320
cgtagtaagg atattatcgc caagtttctc ctttatggac tagtagctgg gactgtcgga   1380
acggctctag gtagtatact tggtcattat ttgctagcca gtgtaatttc aagtgtcatt   1440
acaaaaggca tggtggtggg agaaactcag attcagttct attggaccta tagcttacta   1500
gcttttgtct tgagcttgtt ggcgagtgtg ttaccagcct atctggtggc ttggagggaa   1560
cttcatgacg aagcagccca gcttctactt cctaaacctc ctgtcaaagg agctaaaatc   1620
ttattggagc gtatcggttt tatctggcgt cgtctcagtt ttactcataa ggtaacagcc   1680
cgcaacatct ttcgttataa gcagagaatg ttgatgacaa tctttggtgt ggcaggttct   1740
gtagctctgc tctttgcagg tttgggaatc caatcttctg tagcaggagt tccgtctaaa   1800
cagtttcaac aaatccaaca gtatcagatg cttgtctctg aaaatcctag tgcgaccaat   1860
caggacaagg tagagctagc agaagtgttg aaagggcagg agatactagc ctaccagaaa   1920
atctattcta aagcgctata caaggatttc aaaggcaaag ctggtcttca aaacattact   1980
cttatgatga tagagaagga agatttgact ccctttatcc atcttcaaca tcatcagcag   2040
gagctgacat taaaagatgg catcgttatt acagctaaac tcgcccagct ggcaggtgtc   2100
aaggttgggc agactttaga aattgaaggt aaggaactaa aggtcgttgc tattactgag   2160
aactacgttg gtcactttat ttatatgagt caggctagct atgagcaact ttacggacag   2220
ctaccccaag ccaacactta tctggtctca ttaagggata ccagtgcaac tagtatcgaa   2280
agtcaggcgg gcttgcttat gaatcaatct gcggtgtcca gcgttgtcca aaatgcttca   2340
gccattcgac tcttcgactc tatcgctagc tcactcaatc agaccatgac catcttggtc   2400
atcgtatcgg ttctattagc tattgtcatc ctttacaatc tgaccaatat caacgtagct   2460
gagagaatcc gtgaactctc cactatcaag gttcttggtt ttcataataa tgaagtcacc   2520
ctctacattt accgtgagac gattgtgctg tcccttgtgg gaatcgtact tggtctgata   2580
gctggtttct atttacacca atttttgatt caaatgattt cgcctgcgac tattctcttt   2640
tatccgcagg taggctggga agtctatgta atcccagtgg cagcagtaag catcattttg   2700
accttgcttg gtttcttcgt caattattat ctgagaaagg ttgatatgtt agaagccctg   2760
aaatctgtag ag                                                       2772

<210>   3398
<211>   924
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903539 (0.E+01)

<400>   3398
Met Pro Val Ser Arg Met Trp Cys Ser Thr Ser Ile Leu Arg Ile Leu 
1               5                   10                  15      

Thr Val Trp Ser Thr Ser Met Ile Lys Arg Lys Thr Tyr Trp Lys Asp 
            20                  25                  30          

Leu Val Gln Ser Phe Thr Gly Ser Lys Gly Arg Phe Leu Ser Ile Leu 
        35                  40                  45              

Ile Leu Met Met Leu Gly Ser Leu Ala Leu Val Gly Leu Lys Val Thr 
    50                  55                  60                  

Ser Pro Asn Met Glu Ala Thr Ala Asn Ala Tyr Leu Thr Thr Ala Gln 
65                  70                  75                  80  

Thr Leu Asp Leu Ala Val Met Ser Asn Tyr Gly Leu Asp Gln Ala Asp 
                85                  90                  95      

Gln Glu Glu Leu Lys Gln Thr Glu Gly Ala Glu Val Glu Phe Gly Tyr 
            100                 105                 110         

Leu Thr Asp Val Thr Met Asp Asn Gly Gln Asp Ala Ile Arg Leu Tyr 
        115                 120                 125             

Ser Lys Pro Glu Arg Ile Ser Thr Phe Gln Leu Arg Lys Gly Arg Leu 
    130                 135                 140                 

Pro Gln Ser Asp Lys Glu Ile Ala Leu Ala Thr His Leu Gln Gly Gln 
145                 150                 155                 160 

Tyr Ser Val Gly Gln Glu Ile Ser Phe Lys Glu Lys Glu Glu Gly His 
                165                 170                 175     

Ser Ser Leu Lys Asp His Thr Tyr Thr Ile Thr Gly Phe Val Asp Ser 
            180                 185                 190         

Ala Glu Ile Leu Ser Gln Arg Asp Met Gly Tyr Ala Gly Ser Gly Ser 
        195                 200                 205             

Gly Thr Leu Thr Ala Tyr Gly Val Ile Leu Pro Ser Gln Phe Asp Gln 
    210                 215                 220                 

Lys Val Tyr Asn Ile Ala Arg Leu Lys Tyr Gln Asp Leu Ala Gly Leu 
225                 230                 235                 240 

Asn Ala Phe Ser Ser Ala Tyr Glu Glu Lys Ser Lys Gln His Gln Glu 
                245                 250                 255     

Glu Leu Glu Gln Ile Leu Ser Asp Asn Gly Lys Val Arg Leu Gln Leu 
            260                 265                 270         

Leu Lys Lys Glu Gly Gln Glu Ser Leu Asp Lys Gly Gln Glu Thr Leu 
        275                 280                 285             

Asp Lys Ala Gln Thr Asn Leu Gln Glu Gly Lys Arg Arg Leu Ala Ala 
    290                 295                 300                 

Ala Gln Ala Arg Ile Gln Ala Gln Glu Ser Gln Leu Ala Leu Phe Pro 
305                 310                 315                 320 

Gln Val Gln Arg Glu Gln Ala Ser Ala Gln Leu Thr Gln Ala Lys Gln 
                325                 330                 335     

Glu Leu Gly Lys Glu Glu Asp Lys Leu Lys Gln Ala Glu Gln Asn Leu 
            340                 345                 350         

Ala Gln Glu Lys Glu Lys Leu Glu Lys His Gln Gln Val Leu Asp Asp 
        355                 360                 365             

Leu Ala Glu Pro Arg Tyr Gln Val Tyr Asn Arg Gln Thr Met Pro Gly 
    370                 375                 380                 

Gly Gln Gly Tyr Leu Met Tyr Ser Asn Ala Ser Ser Ser Ile Arg Ala 
385                 390                 395                 400 

Val Gly Asn Ile Phe Pro Val Val Leu Tyr Ala Val Ala Ala Met Val 
                405                 410                 415     

Thr Phe Thr Thr Met Thr Arg Phe Val Asp Glu Glu Arg Thr His Ala 
            420                 425                 430         

Gly Ile Phe Lys Ala Leu Gly Tyr Arg Ser Lys Asp Ile Ile Ala Lys 
        435                 440                 445             

Phe Leu Leu Tyr Gly Leu Val Ala Gly Thr Val Gly Thr Ala Leu Gly 
    450                 455                 460                 

Ser Ile Leu Gly His Tyr Leu Leu Ala Ser Val Ile Ser Ser Val Ile 
465                 470                 475                 480 

Thr Lys Gly Met Val Val Gly Glu Thr Gln Ile Gln Phe Tyr Trp Thr 
                485                 490                 495     

Tyr Ser Leu Leu Ala Phe Val Leu Ser Leu Leu Ala Ser Val Leu Pro 
            500                 505                 510         

Ala Tyr Leu Val Ala Trp Arg Glu Leu His Asp Glu Ala Ala Gln Leu 
        515                 520                 525             

Leu Leu Pro Lys Pro Pro Val Lys Gly Ala Lys Ile Leu Leu Glu Arg 
    530                 535                 540                 

Ile Gly Phe Ile Trp Arg Arg Leu Ser Phe Thr His Lys Val Thr Ala 
545                 550                 555                 560 

Arg Asn Ile Phe Arg Tyr Lys Gln Arg Met Leu Met Thr Ile Phe Gly 
                565                 570                 575     

Val Ala Gly Ser Val Ala Leu Leu Phe Ala Gly Leu Gly Ile Gln Ser 
            580                 585                 590         

Ser Val Ala Gly Val Pro Ser Lys Gln Phe Gln Gln Ile Gln Gln Tyr 
        595                 600                 605             

Gln Met Leu Val Ser Glu Asn Pro Ser Ala Thr Asn Gln Asp Lys Val 
    610                 615                 620                 

Glu Leu Ala Glu Val Leu Lys Gly Gln Glu Ile Leu Ala Tyr Gln Lys 
625                 630                 635                 640 

Ile Tyr Ser Lys Ala Leu Tyr Lys Asp Phe Lys Gly Lys Ala Gly Leu 
                645                 650                 655     

Gln Asn Ile Thr Leu Met Met Ile Glu Lys Glu Asp Leu Thr Pro Phe 
            660                 665                 670         

Ile His Leu Gln His His Gln Gln Glu Leu Thr Leu Lys Asp Gly Ile 
        675                 680                 685             

Val Ile Thr Ala Lys Leu Ala Gln Leu Ala Gly Val Lys Val Gly Gln 
    690                 695                 700                 

Thr Leu Glu Ile Glu Gly Lys Glu Leu Lys Val Val Ala Ile Thr Glu 
705                 710                 715                 720 

Asn Tyr Val Gly His Phe Ile Tyr Met Ser Gln Ala Ser Tyr Glu Gln 
                725                 730                 735     

Leu Tyr Gly Gln Leu Pro Gln Ala Asn Thr Tyr Leu Val Ser Leu Arg 
            740                 745                 750         

Asp Thr Ser Ala Thr Ser Ile Glu Ser Gln Ala Gly Leu Leu Met Asn 
        755                 760                 765             

Gln Ser Ala Val Ser Ser Val Val Gln Asn Ala Ser Ala Ile Arg Leu 
    770                 775                 780                 

Phe Asp Ser Ile Ala Ser Ser Leu Asn Gln Thr Met Thr Ile Leu Val 
785                 790                 795                 800 

Ile Val Ser Val Leu Leu Ala Ile Val Ile Leu Tyr Asn Leu Thr Asn 
                805                 810                 815     

Ile Asn Val Ala Glu Arg Ile Arg Glu Leu Ser Thr Ile Lys Val Leu 
            820                 825                 830         

Gly Phe His Asn Asn Glu Val Thr Leu Tyr Ile Tyr Arg Glu Thr Ile 
        835                 840                 845             

Val Leu Ser Leu Val Gly Ile Val Leu Gly Leu Ile Ala Gly Phe Tyr 
    850                 855                 860                 

Leu His Gln Phe Leu Ile Gln Met Ile Ser Pro Ala Thr Ile Leu Phe 
865                 870                 875                 880 

Tyr Pro Gln Val Gly Trp Glu Val Tyr Val Ile Pro Val Ala Ala Val 
                885                 890                 895     

Ser Ile Ile Leu Thr Leu Leu Gly Phe Phe Val Asn Tyr Tyr Leu Arg 
            900                 905                 910         

Lys Val Asp Met Leu Glu Ala Leu Lys Ser Val Glu 
        915                 920                 

<210>   3399
<211>   708
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3399
gtgggtctga tggcttatat tgagatgaaa cactgttaca agcgttatca ggttggggac   60
acggagattg tggccaattg tgatgtgaat tttgagattg aaaaggggga gctggttatt   120
atccttggtg cttcaggtgc aggcaagtca acagttctta accttcttgg gggaatggat   180
accaatgatg aaggggaaat ctggattgat ggtgttaata ttgcggatta tagttcccac   240
cagcgcacca attaccgtag aaatgatgtg gggtttgttt ttcagtttta taatctagtt   300
tctaatctga cagctaagga aaatgtggaa ctggcttctg aaattgtgac agatgccttg   360
aatcctgatc aggccttgac agatgtaggt ctggctcatc gtctcaataa ctttccagcc   420
cagctttctg gaggggagca acagcgagtc tccattgcac gcgcggtagc caaaaatcct   480
aaaattctcc tttgtgatga accgactgga gccttggatt atcagacggg caagcaggtt   540
ttgaaaattc tccaagacat gtctcgtcaa aagggagcga cggtgatcat cgtgactcat   600
aatggagctt tggcgcccat tgctgatcgc gtgattcaaa tgcacgatgc cagtgtcaag   660
gatgtggtgc tcaaccagca tcctcaggat attgacagtt tggagtac                708

<210>   3400
<211>   236
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903540 (e-130)

<400>   3400
Met Gly Leu Met Ala Tyr Ile Glu Met Lys His Cys Tyr Lys Arg Tyr 
1               5                   10                  15      

Gln Val Gly Asp Thr Glu Ile Val Ala Asn Cys Asp Val Asn Phe Glu 
            20                  25                  30          

Ile Glu Lys Gly Glu Leu Val Ile Ile Leu Gly Ala Ser Gly Ala Gly 
        35                  40                  45              

Lys Ser Thr Val Leu Asn Leu Leu Gly Gly Met Asp Thr Asn Asp Glu 
    50                  55                  60                  

Gly Glu Ile Trp Ile Asp Gly Val Asn Ile Ala Asp Tyr Ser Ser His 
65                  70                  75                  80  

Gln Arg Thr Asn Tyr Arg Arg Asn Asp Val Gly Phe Val Phe Gln Phe 
                85                  90                  95      

Tyr Asn Leu Val Ser Asn Leu Thr Ala Lys Glu Asn Val Glu Leu Ala 
            100                 105                 110         

Ser Glu Ile Val Thr Asp Ala Leu Asn Pro Asp Gln Ala Leu Thr Asp 
        115                 120                 125             

Val Gly Leu Ala His Arg Leu Asn Asn Phe Pro Ala Gln Leu Ser Gly 
    130                 135                 140                 

Gly Glu Gln Gln Arg Val Ser Ile Ala Arg Ala Val Ala Lys Asn Pro 
145                 150                 155                 160 

Lys Ile Leu Leu Cys Asp Glu Pro Thr Gly Ala Leu Asp Tyr Gln Thr 
                165                 170                 175     

Gly Lys Gln Val Leu Lys Ile Leu Gln Asp Met Ser Arg Gln Lys Gly 
            180                 185                 190         

Ala Thr Val Ile Ile Val Thr His Asn Gly Ala Leu Ala Pro Ile Ala 
        195                 200                 205             

Asp Arg Val Ile Gln Met His Asp Ala Ser Val Lys Asp Val Val Leu 
    210                 215                 220                 

Asn Gln His Pro Gln Asp Ile Asp Ser Leu Glu Tyr 
225                 230                 235     

<210>   3401
<211>   2409
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3401
atgataagga ataaaaaaca agattatgta ctggcctaca agcaaccagc ttcaaccact   60
tacatgggtt gggaagaaga agctttaccg ataggcaatg gttctttagg agcaaaagta   120
tttggcctta taggggctga acggattcaa tttaatgaaa aaagtctctg gtctggaggt   180
ccacttcctg atagttcaga ttatcagggt ggaaatcttc aggatcagta tgttttttta   240
gctgagattc ggcaggcttt ggagaagaga gattacaatc tggctaagga actggctgag   300
cagcacctaa ttgggccaaa aacgagtcaa tatgggacct atctgtcttt tggggatatt   360
cacattgagt tcagccagca aggtacgact ttgtctcagg tgacggacta tcagagacag   420
ctgaatatta gtaaggcact tgcgacgact tcttatgtct ataagggaac gcgatttgaa   480
cgtaaagctt ttgcgagttt tccagatgat ctcttggttc aatgttttac taaggaaggg   540
ttggaaactc tagattttac tatagaacta tccttgacct gtgatttggc ttctgatgga   600
aagtatgagc aggaaaaatc tgattacaag gagtgtaagt tggatattac tgattctcat   660
atcttgatga agggaagagt taaggataat gatctgcggt ttgctagtta tctagcttgg   720
gaaacggatg gagatattag agtttggtca gatagggttc agatatcagg agccagttat   780
gccaatctct tcttggccgc taagacggat tttgcccaaa atcctgctag caattatcgc   840
aagaaactag atttagagca acaggtgata gacttggtgg acacagctaa agaaaagggc   900
tatacccaat tgaaatcaag gcatatcgag gactaccaag ccttattcca gcgtgttcaa   960
ttggatttgg aagctgatgt tgacgcatcc actacagatg atttgttaaa aaattataag   1020
ccacaagaag ggcaggcttt ggaggagctg ttcttccagt atggacggta tttattgatt   1080
agttcgtcca gagactgccc agatgctcta ccagctaacc tacagggagt ctggaatgcg   1140
gtcgacaatc ctccttggaa ttcggactat cacttaaatg tcaatctgca gctgaattat   1200
tggccagcct atgttaccaa tctcctagag acggtctttc cagtcatcaa ctatgtagat   1260
gatttgcgtg tctatggtcg tctagcggct gtaaagtatg caggaatcgt ctctcagaaa   1320
ggtgaggaga atggttggtt ggttcatact caagcgactc cctttggttg gacggcacct   1380
ggttgggatt actattgggg ttggtcacca gctgccaatg cgtggatgat gcaaaccgtt   1440
tatgaagcct atttatttta tagggaccaa gactatctca gggagaaaat ttatcccatg   1500
ttgagggaaa cggttcgttt ttggaatgcc tttttacata aggatcagca ggcgcagcgt   1560
tgggtgtctt ctccgtctta ttccccagaa catgggccga tttcgattgg caatacctat   1620
gaccaatctc tgatttggca gttatttcat gattttattc aggctgctca ggaattggga   1680
ctggatgagg acttgttgac tgaggttaag gagaagtctg atttactaaa tcctttgcaa   1740
atcactcaat ctggtcgaat cagggagtgg tatgaggagg aagagcagta ttttcaaaat   1800
gagaaagtgg aggcccagca tcggcacgct tcccatctag tgggactcta tcctggcaat   1860
ctctttagct acaagggaca agagtatatt gaagcggcgc gtgctagcct caatgatcgt   1920
ggagatggcg gcacaggctg gtccaaggct aataagatca atctctgggc gcgtttggga   1980
gatggcaatc gagcccataa attattggca gagcagttaa agacatccac cttgcaaaat   2040
ctttggtgta gccatcctcc ttttcagata gatggtaatt ttggtgctac tagtggcatg   2100
gcagaaatgt tactccagtc tcatgcagct tatctggtac ctctagctgc cctacctgat   2160
gcttggtcaa caggttctgt ttcaggctta atggcacgtg gacattttga agtgagcatg   2220
agctgggaag ataaaaaact cttacagttg accattttat caaggagtgg aggagatttg   2280
cgagtttctt atccagatat tgagaagagt gtgattaaaa tgaatcaaga aaaaataaaa   2340
gcgaaatgca tggggaaaga ttgtatttcg gtggcaacag cagaaggtga tcttgttcaa   2400
ttttatttt                                                           2409

<210>   3402
<211>   803
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15903541 (0.E+01)

<400>   3402
Met Ile Arg Asn Lys Lys Gln Asp Tyr Val Leu Ala Tyr Lys Gln Pro 
1               5                   10                  15      

Ala Ser Thr Thr Tyr Met Gly Trp Glu Glu Glu Ala Leu Pro Ile Gly 
            20                  25                  30          

Asn Gly Ser Leu Gly Ala Lys Val Phe Gly Leu Ile Gly Ala Glu Arg 
        35                  40                  45              

Ile Gln Phe Asn Glu Lys Ser Leu Trp Ser Gly Gly Pro Leu Pro Asp 
    50                  55                  60                  

Ser Ser Asp Tyr Gln Gly Gly Asn Leu Gln Asp Gln Tyr Val Phe Leu 
65                  70                  75                  80  

Ala Glu Ile Arg Gln Ala Leu Glu Lys Arg Asp Tyr Asn Leu Ala Lys 
                85                  90                  95      

Glu Leu Ala Glu Gln His Leu Ile Gly Pro Lys Thr Ser Gln Tyr Gly 
            100                 105                 110         

Thr Tyr Leu Ser Phe Gly Asp Ile His Ile Glu Phe Ser Gln Gln Gly 
        115                 120                 125             

Thr Thr Leu Ser Gln Val Thr Asp Tyr Gln Arg Gln Leu Asn Ile Ser 
    130                 135                 140                 

Lys Ala Leu Ala Thr Thr Ser Tyr Val Tyr Lys Gly Thr Arg Phe Glu 
145                 150                 155                 160 

Arg Lys Ala Phe Ala Ser Phe Pro Asp Asp Leu Leu Val Gln Cys Phe 
                165                 170                 175     

Thr Lys Glu Gly Leu Glu Thr Leu Asp Phe Thr Ile Glu Leu Ser Leu 
            180                 185                 190         

Thr Cys Asp Leu Ala Ser Asp Gly Lys Tyr Glu Gln Glu Lys Ser Asp 
        195                 200                 205             

Tyr Lys Glu Cys Lys Leu Asp Ile Thr Asp Ser His Ile Leu Met Lys 
    210                 215                 220                 

Gly Arg Val Lys Asp Asn Asp Leu Arg Phe Ala Ser Tyr Leu Ala Trp 
225                 230                 235                 240 

Glu Thr Asp Gly Asp Ile Arg Val Trp Ser Asp Arg Val Gln Ile Ser 
                245                 250                 255     

Gly Ala Ser Tyr Ala Asn Leu Phe Leu Ala Ala Lys Thr Asp Phe Ala 
            260                 265                 270         

Gln Asn Pro Ala Ser Asn Tyr Arg Lys Lys Leu Asp Leu Glu Gln Gln 
        275                 280                 285             

Val Ile Asp Leu Val Asp Thr Ala Lys Glu Lys Gly Tyr Thr Gln Leu 
    290                 295                 300                 

Lys Ser Arg His Ile Glu Asp Tyr Gln Ala Leu Phe Gln Arg Val Gln 
305                 310                 315                 320 

Leu Asp Leu Glu Ala Asp Val Asp Ala Ser Thr Thr Asp Asp Leu Leu 
                325                 330                 335     

Lys Asn Tyr Lys Pro Gln Glu Gly Gln Ala Leu Glu Glu Leu Phe Phe 
            340                 345                 350         

Gln Tyr Gly Arg Tyr Leu Leu Ile Ser Ser Ser Arg Asp Cys Pro Asp 
        355                 360                 365             

Ala Leu Pro Ala Asn Leu Gln Gly Val Trp Asn Ala Val Asp Asn Pro 
    370                 375                 380                 

Pro Trp Asn Ser Asp Tyr His Leu Asn Val Asn Leu Gln Leu Asn Tyr 
385                 390                 395                 400 

Trp Pro Ala Tyr Val Thr Asn Leu Leu Glu Thr Val Phe Pro Val Ile 
                405                 410                 415     

Asn Tyr Val Asp Asp Leu Arg Val Tyr Gly Arg Leu Ala Ala Val Lys 
            420                 425                 430         

Tyr Ala Gly Ile Val Ser Gln Lys Gly Glu Glu Asn Gly Trp Leu Val 
        435                 440                 445             

His Thr Gln Ala Thr Pro Phe Gly Trp Thr Ala Pro Gly Trp Asp Tyr 
    450                 455                 460                 

Tyr Trp Gly Trp Ser Pro Ala Ala Asn Ala Trp Met Met Gln Thr Val 
465                 470                 475                 480 

Tyr Glu Ala Tyr Leu Phe Tyr Arg Asp Gln Asp Tyr Leu Arg Glu Lys 
                485                 490                 495     

Ile Tyr Pro Met Leu Arg Glu Thr Val Arg Phe Trp Asn Ala Phe Leu 

            500                 505                 510         

His Lys Asp Gln Gln Ala Gln Arg Trp Val Ser Ser Pro Ser Tyr Ser 
        515                 520                 525             

Pro Glu His Gly Pro Ile Ser Ile Gly Asn Thr Tyr Asp Gln Ser Leu 
    530                 535                 540                 

Ile Trp Gln Leu Phe His Asp Phe Ile Gln Ala Ala Gln Glu Leu Gly 
545                 550                 555                 560 

Leu Asp Glu Asp Leu Leu Thr Glu Val Lys Glu Lys Ser Asp Leu Leu 
                565                 570                 575     

Asn Pro Leu Gln Ile Thr Gln Ser Gly Arg Ile Arg Glu Trp Tyr Glu 
            580                 585                 590         

Glu Glu Glu Gln Tyr Phe Gln Asn Glu Lys Val Glu Ala Gln His Arg 
        595                 600                 605             

His Ala Ser His Leu Val Gly Leu Tyr Pro Gly Asn Leu Phe Ser Tyr 
    610                 615                 620                 

Lys Gly Gln Glu Tyr Ile Glu Ala Ala Arg Ala Ser Leu Asn Asp Arg 
625                 630                 635                 640 

Gly Asp Gly Gly Thr Gly Trp Ser Lys Ala Asn Lys Ile Asn Leu Trp 
                645                 650                 655     

Ala Arg Leu Gly Asp Gly Asn Arg Ala His Lys Leu Leu Ala Glu Gln 
            660                 665                 670         

Leu Lys Thr Ser Thr Leu Gln Asn Leu Trp Cys Ser His Pro Pro Phe 
        675                 680                 685             

Gln Ile Asp Gly Asn Phe Gly Ala Thr Ser Gly Met Ala Glu Met Leu 
    690                 695                 700                 

Leu Gln Ser His Ala Ala Tyr Leu Val Pro Leu Ala Ala Leu Pro Asp 
705                 710                 715                 720 

Ala Trp Ser Thr Gly Ser Val Ser Gly Leu Met Ala Arg Gly His Phe 
                725                 730                 735     

Glu Val Ser Met Ser Trp Glu Asp Lys Lys Leu Leu Gln Leu Thr Ile 
            740                 745                 750         

Leu Ser Arg Ser Gly Gly Asp Leu Arg Val Ser Tyr Pro Asp Ile Glu 
        755                 760                 765             

Lys Ser Val Ile Lys Met Asn Gln Glu Lys Ile Lys Ala Lys Cys Met 
    770                 775                 780                 

Gly Lys Asp Cys Ile Ser Val Ala Thr Ala Glu Gly Asp Leu Val Gln 
785                 790                 795                 800 

Phe Tyr Phe 
            

<210>   3403
<211>   690
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3403
atggtaaaat tggtttttgc tcgccacggt gagtctgaat ggaacaaagc taaccttttc   60
actggttggg ctgatgttga tttgtctgaa aaaggtacac aacaagcgat tgacgctggt   120
aaattgatca aagaagctgg tatcgaattt gaccaagctt acacttcagt attgaaacgt   180
gctatcaaaa caactaactt ggctcttgaa gcttctgacc aattgtgggt tccagttgaa   240
aaatcatggc gcttgaacga acgtcactac ggtggtttga ctggtaaaaa caaagctgaa   300
gctgctgaac aatttggtga tgagcaagtt cacatctggc gtcgttcata cgatgtattg   360
cctccaaaca tggaccgtga tgatgagcac tcagctcaca cagaccgtcg ttacgcttca   420
cttgacgact cagttatccc agatgctgaa aacttgaaag tgactttgga acgtgctctt   480
ccattctggg aagataaaat cgctccagct cttaaagatg gtaaaaacgt attcgtagga   540
gctcacggta actcaatccg tgcccttgta aaacacatca aaggtttgtc agatgacgag   600
atcatggacg tggaaatccc taacttccca ccattggtat tcgaattcga cgaaaaattg   660
aacgtcgttt ctgaatacta ccttggaaaa                                    690

<210>   3404
<211>   230
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoglycerate mutase (gpmA)
<223>   Cellular location: cytoplasm
<223>   Feature of note: secreted
<223>   Similar to strain R6 sequence 15903542 (e-134)

<400>   3404
Met Val Lys Leu Val Phe Ala Arg His Gly Glu Ser Glu Trp Asn Lys 
1               5                   10                  15      

Ala Asn Leu Phe Thr Gly Trp Ala Asp Val Asp Leu Ser Glu Lys Gly 
            20                  25                  30          

Thr Gln Gln Ala Ile Asp Ala Gly Lys Leu Ile Lys Glu Ala Gly Ile 
        35                  40                  45              

Glu Phe Asp Gln Ala Tyr Thr Ser Val Leu Lys Arg Ala Ile Lys Thr 
    50                  55                  60                  

Thr Asn Leu Ala Leu Glu Ala Ser Asp Gln Leu Trp Val Pro Val Glu 
65                  70                  75                  80  

Lys Ser Trp Arg Leu Asn Glu Arg His Tyr Gly Gly Leu Thr Gly Lys 

                85                  90                  95      

Asn Lys Ala Glu Ala Ala Glu Gln Phe Gly Asp Glu Gln Val His Ile 
            100                 105                 110         

Trp Arg Arg Ser Tyr Asp Val Leu Pro Pro Asn Met Asp Arg Asp Asp 
        115                 120                 125             

Glu His Ser Ala His Thr Asp Arg Arg Tyr Ala Ser Leu Asp Asp Ser 
    130                 135                 140                 

Val Ile Pro Asp Ala Glu Asn Leu Lys Val Thr Leu Glu Arg Ala Leu 
145                 150                 155                 160 

Pro Phe Trp Glu Asp Lys Ile Ala Pro Ala Leu Lys Asp Gly Lys Asn 
                165                 170                 175     

Val Phe Val Gly Ala His Gly Asn Ser Ile Arg Ala Leu Val Lys His 
            180                 185                 190         

Ile Lys Gly Leu Ser Asp Asp Glu Ile Met Asp Val Glu Ile Pro Asn 
        195                 200                 205             

Phe Pro Pro Leu Val Phe Glu Phe Asp Glu Lys Leu Asn Val Val Ser 
    210                 215                 220                 

Glu Tyr Tyr Leu Gly Lys 
225                 230 

<210>   3405
<211>   186
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3405
atggaaaata atgactcgtt tactaaacta aaagagtcaa ctcaaaaatt attcgatgcg   60
cagaaaaaaa ggttaaataa tgaagataga atagaaacaa ccaaaaacaa tgtgattgcc   120
aaacattgtc aaacagtcct ttcctttttg gttttgacta gcttttttgt gaaaaattgt   180
gtaaaa                                                              186

<210>   3406
<211>   62
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903543 (9.E-32)

<400>   3406
Met Glu Asn Asn Asp Ser Phe Thr Lys Leu Lys Glu Ser Thr Gln Lys 
1               5                   10                  15      

Leu Phe Asp Ala Gln Lys Lys Arg Leu Asn Asn Glu Asp Arg Ile Glu 
            20                  25                  30          

Thr Thr Lys Asn Asn Val Ile Ala Lys His Cys Gln Thr Val Leu Ser 
        35                  40                  45              

Phe Leu Val Leu Thr Ser Phe Phe Val Lys Asn Cys Val Lys 
    50                  55                  60          

<210>   3407
<211>   222
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3407
gtgcgtattg attcaatcgc atcgtctgtt acaaccggtg tatcgaaagt gattgtttct   60
tttgaactat tggatgttgc tactgtcttc tcatcattac ttgttgaagt attctttgaa   120
ctttatgttc cacatgcaac tagaagagaa agagataata gagctactcc tataccgata   180
aacttttttg ttcttttcat gctaaaatac cttttattct tc                      222

<210>   3408
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   3408
Met Arg Ile Asp Ser Ile Ala Ser Ser Val Thr Thr Gly Val Ser Lys 
1               5                   10                  15      

Val Ile Val Ser Phe Glu Leu Leu Asp Val Ala Thr Val Phe Ser Ser 
            20                  25                  30          

Leu Leu Val Glu Val Phe Phe Glu Leu Tyr Val Pro His Ala Thr Arg 
        35                  40                  45              

Arg Glu Arg Asp Asn Arg Ala Thr Pro Ile Pro Ile Asn Phe Phe Val 
    50                  55                  60                  

Leu Phe Met Leu Lys Tyr Leu Leu Phe Phe 
65                  70                  

<210>   3409
<211>   258
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3409
gtgggaggaa ttttacttct tattggtcct tttgtcttgt tgggaatagc ggtaaacaca   60
gctgctacaa ctcttaatgg aggagctact gcaggggctt tttcaggtgt agccttactc   120
ttgaatgcct tgaagattgc aaatcttgtt cttggtatca ttgctattgt ttactataaa   180
ggagataagc gtgtaggtgc agctccgtct gtactaatga ttgtttctgg tggagttagt   240
ctcattctat tccgttct                                                 258

<210>   3410
<211>   86

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903544 (1.E-19)

<400>   3410
Met Gly Gly Ile Leu Leu Leu Ile Gly Pro Phe Val Leu Leu Gly Ile 
1               5                   10                  15      

Ala Val Asn Thr Ala Ala Thr Thr Leu Asn Gly Gly Ala Thr Ala Gly 
            20                  25                  30          

Ala Phe Ser Gly Val Ala Leu Leu Leu Asn Ala Leu Lys Ile Ala Asn 
        35                  40                  45              

Leu Val Leu Gly Ile Ile Ala Ile Val Tyr Tyr Lys Gly Asp Lys Arg 
    50                  55                  60                  

Val Gly Ala Ala Pro Ser Val Leu Met Ile Val Ser Gly Gly Val Ser 
65                  70                  75                  80  

Leu Ile Leu Phe Arg Ser 
                85      

<210>   3411
<211>   2790
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3411
atgaaactca aagacaccct taatcttggg aaaactgaat tcccaatgcg tgcaggcctt   60
cctaccaaag agccagtttg gcaaaaggaa tgggaagatg caaaacttta tcaacgtcgt   120
caagaattga accaaggaaa acctcatttc accttgcatg atggccctcc atacgctaac   180
ggaaatatcc acgttggaca tgctatgaac aagatttcaa aagatatcat tgttcgttct   240
aagtctatgt caggatttta cgcaccattt attcctggtt gggatactca tggtctgcca   300
atcgagcaag tcttgtcaaa acaaggtgtc aaacgtaaag aaatggactt ggttgagtac   360
ttgaaacttt gccgtgagta cgctctttct caagtagata aacaacgtga agattttaaa   420
cgtttgggtg tttctggtga ctgggaaaat ccatatgtga ccttgactcc tgactatgaa   480
gcagctcaaa ttcgtgtatt tggtgagatg gctaataagg gttatatcta ccgtggtgct   540
aagccagttt actggtcatg gtcatctgag tcagcacttg ctgaagcaga gattgaatac   600
catgacttgg tttcaacttc cctttactat gccaacaagg taaaagatgg caaaggagtt   660
ctagatacag atacttatat cgttgtctgg acaacgactc catttaccat cacagcttct   720

cgtggtttga cggttggtgc agatattgat tacgttttgg ttcaacctgc tggtgaagct   780
cgtaagtttg tcgttgctgc tgaattattg actagcttgt ctgagaaatt tggctgggct   840
gatgttcaag ttttggaaac ttaccgtggc caagaactca accacatcgt aacagaacac   900
ccatgggata cagctgtaga agagttggta attcttggtg accacgttac gactgactct   960
ggtacaggta ttgtccatac agcccctggt tttggtgagg acgattacaa tgttggtatt   1020
gctaataatc ttgaagtcgc agtgactgtt gatgaacgtg gtatcatgat gaagaatgct   1080
ggtcctgaat ttgaaggtca attctatgaa aaggtagttc caactgttat tgaaaaactt   1140
ggtaacctcc ttcttgccca agaagaaatc tctcactcat atccatttga ctggcgtact   1200
aagaaaccaa tcatctggcg tgcagttcca caatggtttg cctcagtttc taaattccgt   1260
caagaaatct tggacgaaat tgaaaaagtg aaattccact cagaatgggg taaagtccgt   1320
ctttacaata tgatccgtga ccgtggtgac tgggttatct ctcgtcaacg tgcttggggt   1380
gttccacttc ctatcttcta cgctgaagat ggtacagcta tcatggtagc tgaaactatt   1440
gaacacgtag ctcaactttt tgaagaatat ggttcaagca tttggtggga acgtgatgcc   1500
aaagacctct tgccagaagg atttactcat ccaggttcac caaacggcga gttcaaaaaa   1560
gaaactgata tcatggacgt ttggtttgac tcaggttcat catggaatgg agtggtggta   1620
aaccgtcctg aattgactta cccagccgac ctttacctag aaggttctga ccaataccgt   1680
ggttggttta actcatcact tatcacatct gttgccaacc atggcgtagc accttacaaa   1740
caaatcttgt cacaaggttt tgcccttgat ggtaaaggtg agaagatgtc taaatctctt   1800
ggaaatacta ttgctccaag cgatgttgaa aaacaattcg gtgctgaaat cttgcgtctc   1860
tgggtaacaa gtgttgactc aagcaatgac gtgcgtatct ctatggatat cttgagccaa   1920
gtttctgaaa cttaccgtaa gattcgtaac actcttcgtt tcttgattgc caatacatct   1980
gactttaacc cagctcaaga tacagtcgct tacgatgagc ttcgttcagt tgataagtac   2040
atgacgattc gctttaacca gcttgtcaag accattcgtg atgcctatgc agactttgaa   2100
ttcttgacga tctacaaggc cttggtgaac tttatcaacg ttgacttgtc agccttctac   2160
cttgattttg ccaaagatgt tgtttacatt gaaggtgcca aatcactgga acgccgtcaa   2220
atgcagactg tcttctatga cattcttgtc aaaatcacca aactcttgac accaatcctt   2280
cctcacactg cggaagaaat ctggtcatat cttgagtttg aaacagaaga cttcgtccaa   2340
ttgtcagaat taccagaagt tcaaactttt gctaaccaag aagaaatctt ggatacatgg   2400
gcagccttca tggactttcg tggacaagca caaaaagcct tggaagaagc tcgtaatgca   2460
aaagttatcg gtaaatcact tgaagcacac ttgacagttt atccaaatga agttgtgaaa   2520
actctactcg aagcagtaaa cagcaatgta gcacaacttt tgatcgtgtc tgagttgacc   2580
atcgcagaag gaccagctcc ggaagctgcc cttagcttcg aagatgtagc cttcacagtt   2640
gaacgtgcta ctggtgaagt atgtgaccgt tgccgtcgta tcgacccaac aacagcagaa   2700
cgcagctacc aggcagttat ctgtgaccac tgtgcaagca tcgtagaaga aaactttgcg   2760
gaagcagtcg cagaaggatt tgaagagaaa                                    2790

<210>   3412
<211>   930
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   isoleucyl-tRNA synthetase (ileS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903545 (0.E+01)

<400>   3412
Met Lys Leu Lys Asp Thr Leu Asn Leu Gly Lys Thr Glu Phe Pro Met 
1               5                   10                  15      

Arg Ala Gly Leu Pro Thr Lys Glu Pro Val Trp Gln Lys Glu Trp Glu 
            20                  25                  30          

Asp Ala Lys Leu Tyr Gln Arg Arg Gln Glu Leu Asn Gln Gly Lys Pro 
        35                  40                  45              

His Phe Thr Leu His Asp Gly Pro Pro Tyr Ala Asn Gly Asn Ile His 
    50                  55                  60                  

Val Gly His Ala Met Asn Lys Ile Ser Lys Asp Ile Ile Val Arg Ser 
65                  70                  75                  80  

Lys Ser Met Ser Gly Phe Tyr Ala Pro Phe Ile Pro Gly Trp Asp Thr 
                85                  90                  95      

His Gly Leu Pro Ile Glu Gln Val Leu Ser Lys Gln Gly Val Lys Arg 
            100                 105                 110         

Lys Glu Met Asp Leu Val Glu Tyr Leu Lys Leu Cys Arg Glu Tyr Ala 
        115                 120                 125             

Leu Ser Gln Val Asp Lys Gln Arg Glu Asp Phe Lys Arg Leu Gly Val 
    130                 135                 140                 

Ser Gly Asp Trp Glu Asn Pro Tyr Val Thr Leu Thr Pro Asp Tyr Glu 
145                 150                 155                 160 

Ala Ala Gln Ile Arg Val Phe Gly Glu Met Ala Asn Lys Gly Tyr Ile 
                165                 170                 175     

Tyr Arg Gly Ala Lys Pro Val Tyr Trp Ser Trp Ser Ser Glu Ser Ala 
            180                 185                 190         

Leu Ala Glu Ala Glu Ile Glu Tyr His Asp Leu Val Ser Thr Ser Leu 
        195                 200                 205             

Tyr Tyr Ala Asn Lys Val Lys Asp Gly Lys Gly Val Leu Asp Thr Asp 
    210                 215                 220                 

Thr Tyr Ile Val Val Trp Thr Thr Thr Pro Phe Thr Ile Thr Ala Ser 
225                 230                 235                 240 

Arg Gly Leu Thr Val Gly Ala Asp Ile Asp Tyr Val Leu Val Gln Pro 
                245                 250                 255     

Ala Gly Glu Ala Arg Lys Phe Val Val Ala Ala Glu Leu Leu Thr Ser 
            260                 265                 270         

Leu Ser Glu Lys Phe Gly Trp Ala Asp Val Gln Val Leu Glu Thr Tyr 
        275                 280                 285             

Arg Gly Gln Glu Leu Asn His Ile Val Thr Glu His Pro Trp Asp Thr 
    290                 295                 300                 

Ala Val Glu Glu Leu Val Ile Leu Gly Asp His Val Thr Thr Asp Ser 
305                 310                 315                 320 

Gly Thr Gly Ile Val His Thr Ala Pro Gly Phe Gly Glu Asp Asp Tyr 
                325                 330                 335     

Asn Val Gly Ile Ala Asn Asn Leu Glu Val Ala Val Thr Val Asp Glu 
            340                 345                 350         

Arg Gly Ile Met Met Lys Asn Ala Gly Pro Glu Phe Glu Gly Gln Phe 
        355                 360                 365             

Tyr Glu Lys Val Val Pro Thr Val Ile Glu Lys Leu Gly Asn Leu Leu 
    370                 375                 380                 

Leu Ala Gln Glu Glu Ile Ser His Ser Tyr Pro Phe Asp Trp Arg Thr 
385                 390                 395                 400 

Lys Lys Pro Ile Ile Trp Arg Ala Val Pro Gln Trp Phe Ala Ser Val 
                405                 410                 415     

Ser Lys Phe Arg Gln Glu Ile Leu Asp Glu Ile Glu Lys Val Lys Phe 
            420                 425                 430         

His Ser Glu Trp Gly Lys Val Arg Leu Tyr Asn Met Ile Arg Asp Arg 
        435                 440                 445             

Gly Asp Trp Val Ile Ser Arg Gln Arg Ala Trp Gly Val Pro Leu Pro 
    450                 455                 460                 

Ile Phe Tyr Ala Glu Asp Gly Thr Ala Ile Met Val Ala Glu Thr Ile 
465                 470                 475                 480 

Glu His Val Ala Gln Leu Phe Glu Glu Tyr Gly Ser Ser Ile Trp Trp 
                485                 490                 495     

Glu Arg Asp Ala Lys Asp Leu Leu Pro Glu Gly Phe Thr His Pro Gly 
            500                 505                 510         

Ser Pro Asn Gly Glu Phe Lys Lys Glu Thr Asp Ile Met Asp Val Trp 
        515                 520                 525             

Phe Asp Ser Gly Ser Ser Trp Asn Gly Val Val Val Asn Arg Pro Glu 
    530                 535                 540                 

Leu Thr Tyr Pro Ala Asp Leu Tyr Leu Glu Gly Ser Asp Gln Tyr Arg 
545                 550                 555                 560 

Gly Trp Phe Asn Ser Ser Leu Ile Thr Ser Val Ala Asn His Gly Val 
                565                 570                 575     

Ala Pro Tyr Lys Gln Ile Leu Ser Gln Gly Phe Ala Leu Asp Gly Lys 
            580                 585                 590         

Gly Glu Lys Met Ser Lys Ser Leu Gly Asn Thr Ile Ala Pro Ser Asp 
        595                 600                 605             

Val Glu Lys Gln Phe Gly Ala Glu Ile Leu Arg Leu Trp Val Thr Ser 
    610                 615                 620                 

Val Asp Ser Ser Asn Asp Val Arg Ile Ser Met Asp Ile Leu Ser Gln 
625                 630                 635                 640 

Val Ser Glu Thr Tyr Arg Lys Ile Arg Asn Thr Leu Arg Phe Leu Ile 
                645                 650                 655     

Ala Asn Thr Ser Asp Phe Asn Pro Ala Gln Asp Thr Val Ala Tyr Asp 
            660                 665                 670         

Glu Leu Arg Ser Val Asp Lys Tyr Met Thr Ile Arg Phe Asn Gln Leu 
        675                 680                 685             

Val Lys Thr Ile Arg Asp Ala Tyr Ala Asp Phe Glu Phe Leu Thr Ile 
    690                 695                 700                 

Tyr Lys Ala Leu Val Asn Phe Ile Asn Val Asp Leu Ser Ala Phe Tyr 
705                 710                 715                 720 

Leu Asp Phe Ala Lys Asp Val Val Tyr Ile Glu Gly Ala Lys Ser Leu 
                725                 730                 735     

Glu Arg Arg Gln Met Gln Thr Val Phe Tyr Asp Ile Leu Val Lys Ile 
            740                 745                 750         

Thr Lys Leu Leu Thr Pro Ile Leu Pro His Thr Ala Glu Glu Ile Trp 
        755                 760                 765             

Ser Tyr Leu Glu Phe Glu Thr Glu Asp Phe Val Gln Leu Ser Glu Leu 
    770                 775                 780                 

Pro Glu Val Gln Thr Phe Ala Asn Gln Glu Glu Ile Leu Asp Thr Trp 
785                 790                 795                 800 

Ala Ala Phe Met Asp Phe Arg Gly Gln Ala Gln Lys Ala Leu Glu Glu 
                805                 810                 815     

Ala Arg Asn Ala Lys Val Ile Gly Lys Ser Leu Glu Ala His Leu Thr 
            820                 825                 830         

Val Tyr Pro Asn Glu Val Val Lys Thr Leu Leu Glu Ala Val Asn Ser 
        835                 840                 845             

Asn Val Ala Gln Leu Leu Ile Val Ser Glu Leu Thr Ile Ala Glu Gly 
    850                 855                 860                 

Pro Ala Pro Glu Ala Ala Leu Ser Phe Glu Asp Val Ala Phe Thr Val 
865                 870                 875                 880 

Glu Arg Ala Thr Gly Glu Val Cys Asp Arg Cys Arg Arg Ile Asp Pro 
                885                 890                 895     

Thr Thr Ala Glu Arg Ser Tyr Gln Ala Val Ile Cys Asp His Cys Ala 
            900                 905                 910         

Ser Ile Val Glu Glu Asn Phe Ala Glu Ala Val Ala Glu Gly Phe Glu 
        915                 920                 925             

Glu Lys 
    930 

<210>   3413
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3413
ttgattcaat accgggattt gaagcaccgc aagaatctgt tacaatttta taagaaatat   60
tctgagaaca atatcttatc cttatatttc cagcgagcag gagatggtgt gagtcctgta   120
atccctattg ataagattat cctctcaaaa actcaagtc                          159

<210>   3414
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903546 (2.E-22)

<400>   3414
Met Ile Gln Tyr Arg Asp Leu Lys His Arg Lys Asn Leu Leu Gln Phe 
1               5                   10                  15      

Tyr Lys Lys Tyr Ser Glu Asn Asn Ile Leu Ser Leu Tyr Phe Gln Arg 
            20                  25                  30          

Ala Gly Asp Gly Val Ser Pro Val Ile Pro Ile Asp Lys Ile Ile Leu 
        35                  40                  45              

Ser Lys Thr Gln Val 
    50              

<210>   3415
<211>   798
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3415
gtgaggaata gaatgccaat tacatcatta gaaataaagg acaagacttt tggaactcga   60
ttcagaggtt ttgatccaga agaagtcgat gaatttttag atattgtggt tcgtgattac   120
gaagatcttg tgcgtgcgaa tcatgataaa aatttgcgta ttaagagttt agaagagcgt   180
ttgtcttact ttgatgaaat aaaagattca ttgagccagt ctgtattgat tgctcaggat   240
acagctgaga gagtgaaaca ggcggcgcat gaacgttcaa acaatatcat tcatcaagca   300
gagcaagatg cgcaacgctt gttggaagaa gctaaatata aggcaaacga gattcttcgt   360
caagcaactg ataatgctaa gaaagtcgct gttgaaacag aagaattgaa gaacaagagc   420
cgtgtcttcc accaacgtct caaatctaca attgagagtc agttggctat tgttgaatct   480
tcagattggg aagatattct ccgtccaaca gctacttatc ttcaaaccag tgatgaagcc   540
tttaaagaag tggttagcga agtacttgga gaaccgattc cagctccaat tgaagaagaa   600
ccaattgata tgacacgtca gttctctcaa gcagaaatgg cagaattaca agctcgtatt   660
gaggtagccg ataaagaatt gtctgaattt gaagctcaga ttaaacagga agtggaagct   720
ccaactcctg tagtgagtcc tcaagttgaa gaagagcctc tgctcatcca gttggcccaa   780
tgtatgaaga accagaag                                                 798

<210>   3416
<211>   266
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell division protein DivIVA (divIVA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903548 (e-144)

<400>   3416
Met Arg Asn Arg Met Pro Ile Thr Ser Leu Glu Ile Lys Asp Lys Thr 
1               5                   10                  15      


Phe Gly Thr Arg Phe Arg Gly Phe Asp Pro Glu Glu Val Asp Glu Phe 
            20                  25                  30          

Leu Asp Ile Val Val Arg Asp Tyr Glu Asp Leu Val Arg Ala Asn His 
        35                  40                  45              

Asp Lys Asn Leu Arg Ile Lys Ser Leu Glu Glu Arg Leu Ser Tyr Phe 
    50                  55                  60                  

Asp Glu Ile Lys Asp Ser Leu Ser Gln Ser Val Leu Ile Ala Gln Asp 
65                  70                  75                  80  

Thr Ala Glu Arg Val Lys Gln Ala Ala His Glu Arg Ser Asn Asn Ile 
                85                  90                  95      

Ile His Gln Ala Glu Gln Asp Ala Gln Arg Leu Leu Glu Glu Ala Lys 
            100                 105                 110         

Tyr Lys Ala Asn Glu Ile Leu Arg Gln Ala Thr Asp Asn Ala Lys Lys 
        115                 120                 125             

Val Ala Val Glu Thr Glu Glu Leu Lys Asn Lys Ser Arg Val Phe His 
    130                 135                 140                 

Gln Arg Leu Lys Ser Thr Ile Glu Ser Gln Leu Ala Ile Val Glu Ser 
145                 150                 155                 160 

Ser Asp Trp Glu Asp Ile Leu Arg Pro Thr Ala Thr Tyr Leu Gln Thr 
                165                 170                 175     

Ser Asp Glu Ala Phe Lys Glu Val Val Ser Glu Val Leu Gly Glu Pro 
            180                 185                 190         

Ile Pro Ala Pro Ile Glu Glu Glu Pro Ile Asp Met Thr Arg Gln Phe 
        195                 200                 205             

Ser Gln Ala Glu Met Ala Glu Leu Gln Ala Arg Ile Glu Val Ala Asp 
    210                 215                 220                 

Lys Glu Leu Ser Glu Phe Glu Ala Gln Ile Lys Gln Glu Val Glu Ala 
225                 230                 235                 240 

Pro Thr Pro Val Val Ser Pro Gln Val Glu Glu Glu Pro Leu Leu Ile 
                245                 250                 255     

Gln Leu Ala Gln Cys Met Lys Asn Gln Lys 
            260                 265     

<210>   3417
<211>   783
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3417
atgaataaag ggatttatca gcatttctcc atagaagatc gtccatttct tgacaaggga   60
atggaatgga taaagaaggt agaagatagc tatgctcctt ttttaactcc ttttatcaat   120
cctcatcagg agaagctatt aaagattttg gccaaaacct atggtcttgc ttgtagcagt   180
agtggggaat tcgtctcgag tgagtatgtt cgagttttat tatacccaga ttatttccaa   240
ccagagtttt cagattttga aatatctctc caggaaattg tgtattccaa taaatttgaa   300
catttaacgc atgctaagat tttagggaca gtcatcaatc aattagggat tgaacggaaa   360
ctttttggag atatcctagt agatgaagaa cgggcgcaga ttatgattaa tcagcagttt   420
cttcttctct ttcaagatgg actaaagaaa attggtcgta tacctgtttc gctggaggaa   480
cgtcctttca ccgagaaaat agataagcta gaacagtatc gagaactgga tttatctgtg   540
tctagttttc gattagatgt tcttttatca aatgttttga aactatctag gaatcaagca   600
aaccagttga ttgaaaagaa acttgtccaa gtaaattatc atgtggtaga caaatcagat   660
tacactgttc aagttggaga cttgattagt gtgagaaaat ttggtcgctt gagattactt   720
caagataagg gacaaacgaa aaaagagaag aaaaaaataa ccgtccagtt attattaagt   780
aag                                                                 783

<210>   3418
<211>   261
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ylmH protein (ylmH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903549 (e-146)

<400>   3418
Met Asn Lys Gly Ile Tyr Gln His Phe Ser Ile Glu Asp Arg Pro Phe 
1               5                   10                  15      

Leu Asp Lys Gly Met Glu Trp Ile Lys Lys Val Glu Asp Ser Tyr Ala 
            20                  25                  30          

Pro Phe Leu Thr Pro Phe Ile Asn Pro His Gln Glu Lys Leu Leu Lys 
        35                  40                  45              

Ile Leu Ala Lys Thr Tyr Gly Leu Ala Cys Ser Ser Ser Gly Glu Phe 
    50                  55                  60                  

Val Ser Ser Glu Tyr Val Arg Val Leu Leu Tyr Pro Asp Tyr Phe Gln 
65                  70                  75                  80  

Pro Glu Phe Ser Asp Phe Glu Ile Ser Leu Gln Glu Ile Val Tyr Ser 
                85                  90                  95      

Asn Lys Phe Glu His Leu Thr His Ala Lys Ile Leu Gly Thr Val Ile 
            100                 105                 110         

Asn Gln Leu Gly Ile Glu Arg Lys Leu Phe Gly Asp Ile Leu Val Asp 
        115                 120                 125             

Glu Glu Arg Ala Gln Ile Met Ile Asn Gln Gln Phe Leu Leu Leu Phe 
    130                 135                 140                 

Gln Asp Gly Leu Lys Lys Ile Gly Arg Ile Pro Val Ser Leu Glu Glu 
145                 150                 155                 160 

Arg Pro Phe Thr Glu Lys Ile Asp Lys Leu Glu Gln Tyr Arg Glu Leu 
                165                 170                 175     

Asp Leu Ser Val Ser Ser Phe Arg Leu Asp Val Leu Leu Ser Asn Val 
            180                 185                 190         

Leu Lys Leu Ser Arg Asn Gln Ala Asn Gln Leu Ile Glu Lys Lys Leu 
        195                 200                 205             

Val Gln Val Asn Tyr His Val Val Asp Lys Ser Asp Tyr Thr Val Gln 
    210                 215                 220                 

Val Gly Asp Leu Ile Ser Val Arg Lys Phe Gly Arg Leu Arg Leu Leu 
225                 230                 235                 240 

Gln Asp Lys Gly Gln Thr Lys Lys Glu Lys Lys Lys Ile Thr Val Gln 
                245                 250                 255     

Leu Leu Leu Ser Lys 
            260     

<210>   3419
<211>   261
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3419
atgatttttt taattcgtat gatttataat gcagtggata tttactccct gattttggta   60
gccttcgctg tcatgtcttg gtttccaggt gcctacgaat ccagtttagg tcgttggatt   120
gtagcgttgg tgaaaccagt gcttgctccc ttgcaacgcc tgcctttaca gatagcgggt   180
cttgatttat ctgtttgggt tgcgattgtt ttggttcgat ttttaggaga aaacctagtg   240
cgttttctgg cgatgatagg a                                             261

<210>   3420
<211>   87
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ylmG protein (ylmG)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903550 (1.E-44)

<400>   3420
Met Ile Phe Leu Ile Arg Met Ile Tyr Asn Ala Val Asp Ile Tyr Ser 
1               5                   10                  15      

Leu Ile Leu Val Ala Phe Ala Val Met Ser Trp Phe Pro Gly Ala Tyr 
            20                  25                  30          

Glu Ser Ser Leu Gly Arg Trp Ile Val Ala Leu Val Lys Pro Val Leu 
        35                  40                  45              

Ala Pro Leu Gln Arg Leu Pro Leu Gln Ile Ala Gly Leu Asp Leu Ser 
    50                  55                  60                  

Val Trp Val Ala Ile Val Leu Val Arg Phe Leu Gly Glu Asn Leu Val 
65                  70                  75                  80  

Arg Phe Leu Ala Met Ile Gly 
                85          

<210>   3421
<211>   537
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3421
atgtctttaa aagatagatt cgatagattt atagattatt ttacggagga tgaggattca   60
agtctccctt atgaaaaaag agatgagcct gtgtttactt cagtaaattc ttcacaggaa   120
ccggctctcc caatgaatca accttcacag tcggctggca caaaagagaa caatatcacc   180
agacttcatg caagacaaca ggaattggca aatcagagtc agcgtgcaac ggataaggtc   240
attatagatg ttcgttatcc tagaaaatat gaggatgcaa cagaaattgt tgatttattg   300
gcaggaaacg aaagtatctt gattgatttt cagtatatga cagaggtgca ggctcgtcgt   360
tgtttggact atttggatgg agcttgtcat gttttagctg gaaatttgaa aaaggtagct   420
tctaccatgt atttgttgac accagtgaac gttattgtaa atgttgaaga tatccgttta   480
ccagatgaag atcaacaggg tgagttcggt tttgatatga agcgaaatag agtacga      537

<210>   3422
<211>   179
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ylmF protein (ylmF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903551 (e-100)

<400>   3422
Met Ser Leu Lys Asp Arg Phe Asp Arg Phe Ile Asp Tyr Phe Thr Glu 
1               5                   10                  15      

Asp Glu Asp Ser Ser Leu Pro Tyr Glu Lys Arg Asp Glu Pro Val Phe 
            20                  25                  30          

Thr Ser Val Asn Ser Ser Gln Glu Pro Ala Leu Pro Met Asn Gln Pro 
        35                  40                  45              

Ser Gln Ser Ala Gly Thr Lys Glu Asn Asn Ile Thr Arg Leu His Ala 
    50                  55                  60                  

Arg Gln Gln Glu Leu Ala Asn Gln Ser Gln Arg Ala Thr Asp Lys Val 
65                  70                  75                  80  

Ile Ile Asp Val Arg Tyr Pro Arg Lys Tyr Glu Asp Ala Thr Glu Ile 
                85                  90                  95      

Val Asp Leu Leu Ala Gly Asn Glu Ser Ile Leu Ile Asp Phe Gln Tyr 
            100                 105                 110         

Met Thr Glu Val Gln Ala Arg Arg Cys Leu Asp Tyr Leu Asp Gly Ala 
        115                 120                 125             

Cys His Val Leu Ala Gly Asn Leu Lys Lys Val Ala Ser Thr Met Tyr 
    130                 135                 140                 

Leu Leu Thr Pro Val Asn Val Ile Val Asn Val Glu Asp Ile Arg Leu 
145                 150                 155                 160 

Pro Asp Glu Asp Gln Gln Gly Glu Phe Gly Phe Asp Met Lys Arg Asn 
                165                 170                 175     

Arg Val Arg 
            

<210>   3423
<211>   669
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3423
atgaatgtaa aagaaaatac agaacttgtt tttcgagaag ttgcagaggc tagtctgagt   60
gctcatcgag agagtggttc ggtctctgtc attgcagtta ccaagtatgt agatgtaccg   120
acagcggaag ccttgcttcc gctaggtgtc catcatatcg gtgaaaatcg tgtagataag   180
tttctggaaa aatatgaagc tttaaaagat cgagatgtga cttggcattt gattggtacc   240
ttgcaaagac gtaaggtgaa agatgtcatt caatacgttg attatttcca tgcattggac   300
tcagtaaagc tagcagggga aattcaaaaa agaagtgacc gagtcatcaa gtgtttcctt   360
caagtaaata tttctaaaga agaaagcaaa cacggttttt cgagagagga actgctggaa   420
atcttgccag agttagccag actagataag attgaatatg ttggtttaat gacgatggca   480
ccttttgagg ctagcagtga gcagttgaaa gagattttca aggcggccca agatttacaa   540
agagaaattc aagagaaaca aattccaaat atgcctatga ccgagttaag tatgggaatg   600
agtcgtgatt ataaagaagc gattcaattc ggttccactt ttgttcgtat aggtacatca   660
ttttttaag                                                           669

<210>   3424
<211>   223
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ylmE protein (ylmE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903552 (e-123)

<400>   3424
Met Asn Val Lys Glu Asn Thr Glu Leu Val Phe Arg Glu Val Ala Glu 
1               5                   10                  15      

Ala Ser Leu Ser Ala His Arg Glu Ser Gly Ser Val Ser Val Ile Ala 
            20                  25                  30          

Val Thr Lys Tyr Val Asp Val Pro Thr Ala Glu Ala Leu Leu Pro Leu 
        35                  40                  45              

Gly Val His His Ile Gly Glu Asn Arg Val Asp Lys Phe Leu Glu Lys 
    50                  55                  60                  

Tyr Glu Ala Leu Lys Asp Arg Asp Val Thr Trp His Leu Ile Gly Thr 
65                  70                  75                  80  

Leu Gln Arg Arg Lys Val Lys Asp Val Ile Gln Tyr Val Asp Tyr Phe 
                85                  90                  95      

His Ala Leu Asp Ser Val Lys Leu Ala Gly Glu Ile Gln Lys Arg Ser 
            100                 105                 110         

Asp Arg Val Ile Lys Cys Phe Leu Gln Val Asn Ile Ser Lys Glu Glu 
        115                 120                 125             

Ser Lys His Gly Phe Ser Arg Glu Glu Leu Leu Glu Ile Leu Pro Glu 
    130                 135                 140                 

Leu Ala Arg Leu Asp Lys Ile Glu Tyr Val Gly Leu Met Thr Met Ala 
145                 150                 155                 160 

Pro Phe Glu Ala Ser Ser Glu Gln Leu Lys Glu Ile Phe Lys Ala Ala 
                165                 170                 175     

Gln Asp Leu Gln Arg Glu Ile Gln Glu Lys Gln Ile Pro Asn Met Pro 
            180                 185                 190         

Met Thr Glu Leu Ser Met Gly Met Ser Arg Asp Tyr Lys Glu Ala Ile 
        195                 200                 205             

Gln Phe Gly Ser Thr Phe Val Arg Ile Gly Thr Ser Phe Phe Lys 
    210                 215                 220             

<210>   3425
<211>   1257
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3425
atgacatttt catttgatac agctgctgct caaggggcag tgattaaagt aattggtgtc   60
ggtggaggtg gtggcaatgc catcaaccgt atggtcgacg aaggtgttac aggcgtagaa   120
tttatcgcag caaacacaga tgtacaagca ttgagtagta caaaagctga gactgttatt   180
cagttgggac ctaaattgac tcgtggtttg ggtgcaggag gtcaacctga ggttggtcgt   240
aaagccgctg aagaaagcga agaaacactg acggaagcta ttagtggtgc cgatatggtc   300
ttcatcactg ctggtatggg aggaggctct ggaactggag ctgctcctgt tattgctcgt   360
atcgccaaag atttaggtgc gcttacagtt ggtgttgtaa cacgtccctt tggttttgaa   420
ggaagtaagc gtggacaatt tgctgtagaa ggaatcaatc aacttcgtga gcatgtagac   480
actctattga ttatctcaaa caacaatttg cttgaaattg ttgataagaa aacaccgctt   540
ttggaggctc ttagcgaagc ggataacgtt cttcgtcaag gtgttcaagg gattaccgat   600
ttgattacca atccaggatt gattaacctt gactttgccg atgtgaaaac ggtaatggca   660
aacaaaggga atgctcttat gggtattggt atcggtagtg gagaagaacg tgtggtagaa   720
gcggcacgta aggcaatcta ttcaccactt cttgaaacaa ctattgacgg tgctgaggat   780
gttatcgtca acgttactgg tggtcttgac ttaaccttga ttgaggcaga agaggcttca   840
caaattgtga accaggcagc aggtcaagga gtgaacatct ggctcggtac ttcaattgat   900
gaaagtatgc gtgatgaaat tcgtgtaaca gttgttgcaa cgggtgttcg tcaagaccgc   960
gtagaaaagg ttgtggctcc acaagctaga tctgctacta actaccgtga gacagtgaaa   1020
ccagctcatt cacatggctt tgatcgtcat tttgatatgg cagaaacagt tgaattgcca   1080
aaacaaaatc cacgtcgttt ggaaccaact caggcatctg cttttggtga ttgggatctt   1140
cgccgtgaat cgattgttcg tacaacagat tcagtcgttt ctccagtcga gcgctttgaa   1200
gccccaattt cacaagatga agatgaattg gatacacctc catttttcaa aaatcgt      1257

<210>   3426
<211>   419
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell division protein FtsZ (ftsZ)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903553 (0.E+01)

<400>   3426
Met Thr Phe Ser Phe Asp Thr Ala Ala Ala Gln Gly Ala Val Ile Lys 
1               5                   10                  15      

Val Ile Gly Val Gly Gly Gly Gly Gly Asn Ala Ile Asn Arg Met Val 
            20                  25                  30          

Asp Glu Gly Val Thr Gly Val Glu Phe Ile Ala Ala Asn Thr Asp Val 
        35                  40                  45              

Gln Ala Leu Ser Ser Thr Lys Ala Glu Thr Val Ile Gln Leu Gly Pro 
    50                  55                  60                  

Lys Leu Thr Arg Gly Leu Gly Ala Gly Gly Gln Pro Glu Val Gly Arg 
65                  70                  75                  80  

Lys Ala Ala Glu Glu Ser Glu Glu Thr Leu Thr Glu Ala Ile Ser Gly 
                85                  90                  95      

Ala Asp Met Val Phe Ile Thr Ala Gly Met Gly Gly Gly Ser Gly Thr 
            100                 105                 110         

Gly Ala Ala Pro Val Ile Ala Arg Ile Ala Lys Asp Leu Gly Ala Leu 
        115                 120                 125             

Thr Val Gly Val Val Thr Arg Pro Phe Gly Phe Glu Gly Ser Lys Arg 
    130                 135                 140                 

Gly Gln Phe Ala Val Glu Gly Ile Asn Gln Leu Arg Glu His Val Asp 
145                 150                 155                 160 

Thr Leu Leu Ile Ile Ser Asn Asn Asn Leu Leu Glu Ile Val Asp Lys 
                165                 170                 175     

Lys Thr Pro Leu Leu Glu Ala Leu Ser Glu Ala Asp Asn Val Leu Arg 
            180                 185                 190         

Gln Gly Val Gln Gly Ile Thr Asp Leu Ile Thr Asn Pro Gly Leu Ile 
        195                 200                 205             

Asn Leu Asp Phe Ala Asp Val Lys Thr Val Met Ala Asn Lys Gly Asn 
    210                 215                 220                 

Ala Leu Met Gly Ile Gly Ile Gly Ser Gly Glu Glu Arg Val Val Glu 
225                 230                 235                 240 

Ala Ala Arg Lys Ala Ile Tyr Ser Pro Leu Leu Glu Thr Thr Ile Asp 
                245                 250                 255     

Gly Ala Glu Asp Val Ile Val Asn Val Thr Gly Gly Leu Asp Leu Thr 
            260                 265                 270         

Leu Ile Glu Ala Glu Glu Ala Ser Gln Ile Val Asn Gln Ala Ala Gly 
        275                 280                 285             

Gln Gly Val Asn Ile Trp Leu Gly Thr Ser Ile Asp Glu Ser Met Arg 
    290                 295                 300                 

Asp Glu Ile Arg Val Thr Val Val Ala Thr Gly Val Arg Gln Asp Arg 
305                 310                 315                 320 

Val Glu Lys Val Val Ala Pro Gln Ala Arg Ser Ala Thr Asn Tyr Arg 
                325                 330                 335     

Glu Thr Val Lys Pro Ala His Ser His Gly Phe Asp Arg His Phe Asp 
            340                 345                 350         

Met Ala Glu Thr Val Glu Leu Pro Lys Gln Asn Pro Arg Arg Leu Glu 
        355                 360                 365             

Pro Thr Gln Ala Ser Ala Phe Gly Asp Trp Asp Leu Arg Arg Glu Ser 
    370                 375                 380                 

Ile Val Arg Thr Thr Asp Ser Val Val Ser Pro Val Glu Arg Phe Glu 
385                 390                 395                 400 

Ala Pro Ile Ser Gln Asp Glu Asp Glu Leu Asp Thr Pro Pro Phe Phe 
                405                 410                 415     

Lys Asn Arg 
            

<210>   3427
<211>   1317
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3427
gtgcttgtgg ccgagcagag aaatggtgaa ttaaatgtaa ttggcgtgag taatgccaaa   60
agtaaaggtg taaaggatgg aattattgtt gatattgatg cagcagcaac tgctatcaag   120
tcagccattt cccaagcgga agaaaaggca ggcatttcga ttaaatcagt gaatgtcggc   180
ttgcctggta atcttttgca ggtagaacca actcagggga tgattccagt aacatctgat   240
actaaggaaa ttacggatca agatgttgaa aatgttgtca aatcagcttt gacaaagagt   300
atgacacctg accgtgaagt cattaccttt attcctgaag aatttattgt ggatggtttc   360
caagggattc gtgacccacg tggcatgatg ggggttcgcc ttgaaatgcg tggtttgctt   420
tatacaggac ctcgtactat cttgcacaat ttgcgtaaga cggttgagcg tgcaggtgtt   480
caggttgaaa atgttatcat ttcaccacta gcaatggttc agtctgtttt gaacgaaggg   540
gaacgtgaat ttggtgctac agtgattgat atgggggcag gtcaaacgac tgtcgctaca   600
atccgtaatc aagaactcca gttcacacat attctccaag aaggtggaga ttatgtaact   660
aaagatatct ccaaggtttt gaaaacctct cgcaaattag cggaaggctt gaaactgaat   720
tacggggaag cctatccgcc tcttgcaagc aaagaaacct tccaagtaga ggttattgga   780
gaagtagaag cagtcgaagt gacggaagcc tacttgtcag aaattatttc tgcacgaatc   840
aagcacatcc ttgaacaaat caagcaagaa ttagatagaa ggcgtctatt ggacctccct   900
ggtggtattg tcttaatcgg tgggaatgcc attttaccag gtatggttga gcttgctcag   960
gaagtctttg gcgtccgtgt caagctttat gttccaaatc aagttggtat ccgtaatcca   1020
gcctttgcgc atgtgattag tttatcagaa tttgcgggtc aattaacaga agttaatctt   1080
ttggctcagg gagcgataaa aggtgagaat gacttaagtc atcagccaat tagttttggt   1140
gggatgctgc aaaaaacagc tcagtttgta caatcaacgc ctgttcaacc agctcctgct   1200
ccagaagtag agccggtggc gcctacagaa ccaatggcgg atttccaaca agcttcacaa   1260
aataaaccga aattagcaga tcgtttccgt ggattgatcg gaagcatgtt tgacgaa      1317

<210>   3428
<211>   439
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell division protein FtsA (ftsA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903554 (0.E+01)

<400>   3428
Met Leu Val Ala Glu Gln Arg Asn Gly Glu Leu Asn Val Ile Gly Val 
1               5                   10                  15      

Ser Asn Ala Lys Ser Lys Gly Val Lys Asp Gly Ile Ile Val Asp Ile 
            20                  25                  30          

Asp Ala Ala Ala Thr Ala Ile Lys Ser Ala Ile Ser Gln Ala Glu Glu 
        35                  40                  45              

Lys Ala Gly Ile Ser Ile Lys Ser Val Asn Val Gly Leu Pro Gly Asn 
    50                  55                  60                  

Leu Leu Gln Val Glu Pro Thr Gln Gly Met Ile Pro Val Thr Ser Asp 
65                  70                  75                  80  

Thr Lys Glu Ile Thr Asp Gln Asp Val Glu Asn Val Val Lys Ser Ala 
                85                  90                  95      

Leu Thr Lys Ser Met Thr Pro Asp Arg Glu Val Ile Thr Phe Ile Pro 
            100                 105                 110         

Glu Glu Phe Ile Val Asp Gly Phe Gln Gly Ile Arg Asp Pro Arg Gly 
        115                 120                 125             

Met Met Gly Val Arg Leu Glu Met Arg Gly Leu Leu Tyr Thr Gly Pro 
    130                 135                 140                 

Arg Thr Ile Leu His Asn Leu Arg Lys Thr Val Glu Arg Ala Gly Val 
145                 150                 155                 160 

Gln Val Glu Asn Val Ile Ile Ser Pro Leu Ala Met Val Gln Ser Val 
                165                 170                 175     

Leu Asn Glu Gly Glu Arg Glu Phe Gly Ala Thr Val Ile Asp Met Gly 
            180                 185                 190         

Ala Gly Gln Thr Thr Val Ala Thr Ile Arg Asn Gln Glu Leu Gln Phe 
        195                 200                 205             

Thr His Ile Leu Gln Glu Gly Gly Asp Tyr Val Thr Lys Asp Ile Ser 
    210                 215                 220                 

Lys Val Leu Lys Thr Ser Arg Lys Leu Ala Glu Gly Leu Lys Leu Asn 
225                 230                 235                 240 

Tyr Gly Glu Ala Tyr Pro Pro Leu Ala Ser Lys Glu Thr Phe Gln Val 
                245                 250                 255     

Glu Val Ile Gly Glu Val Glu Ala Val Glu Val Thr Glu Ala Tyr Leu 
            260                 265                 270         

Ser Glu Ile Ile Ser Ala Arg Ile Lys His Ile Leu Glu Gln Ile Lys 
        275                 280                 285             

Gln Glu Leu Asp Arg Arg Arg Leu Leu Asp Leu Pro Gly Gly Ile Val 
    290                 295                 300                 

Leu Ile Gly Gly Asn Ala Ile Leu Pro Gly Met Val Glu Leu Ala Gln 
305                 310                 315                 320 

Glu Val Phe Gly Val Arg Val Lys Leu Tyr Val Pro Asn Gln Val Gly 
                325                 330                 335     

Ile Arg Asn Pro Ala Phe Ala His Val Ile Ser Leu Ser Glu Phe Ala 
            340                 345                 350         

Gly Gln Leu Thr Glu Val Asn Leu Leu Ala Gln Gly Ala Ile Lys Gly 
        355                 360                 365             

Glu Asn Asp Leu Ser His Gln Pro Ile Ser Phe Gly Gly Met Leu Gln 
    370                 375                 380                 

Lys Thr Ala Gln Phe Val Gln Ser Thr Pro Val Gln Pro Ala Pro Ala 
385                 390                 395                 400 

Pro Glu Val Glu Pro Val Ala Pro Thr Glu Pro Met Ala Asp Phe Gln 
                405                 410                 415     

Gln Ala Ser Gln Asn Lys Pro Lys Leu Ala Asp Arg Phe Arg Gly Leu 
            420                 425                 430         

Ile Gly Ser Met Phe Asp Glu 
        435                 

<210>   3429
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3429
ttgacagagc ttgttccaat atctagacct gtaaaaaagc cttctctagc cattacatcg   60
cttcctctct atcttccaag tttcgcactt cgtattattc ca                      102

<210>   3430
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3430
Met Thr Glu Leu Val Pro Ile Ser Arg Pro Val Lys Lys Pro Ser Leu 
1               5                   10                  15      

Ala Ile Thr Ser Leu Pro Leu Tyr Leu Pro Ser Phe Ala Leu Arg Ile 
            20                  25                  30          

Ile Pro 
        

<210>   3431
<211>   702
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3431
atgaatttat gggatatttt ctttacgact caggcaaccg agccgcccaa atttgacctt   60
ttttggtatg ttagcctatt tacgctctta gccttaacct tttatacagc ccatcgctat   120
cgtgaaaaga aggtttacca acgatttttc caaatcttgc agactgttca gttaatcctt   180
ctttatggtt ggtactgggt caatcatatg ccactgtcag aaagcctacc cttttaccat   240
tgccgtatgg ctatgtttgt ggtactcttg cttcctggtc aatccaaata taaacaatac   300
tttgcattat tgggaacatt tgggacatta gcagcctttg tttatccagt gccagatgct   360
tacccttttc cacatatcac cattctatcc tttatctttg gtcatttagc actcttgggg   420
aactctctag tttatctatt gagacagtat aatgcgcgat tgctggatgt gaagggaatt   480
tttctcatga cctttgccct aaatgccttg atttttgtgg tcaatttggt gacaggtggc   540
gattacggat ttttgacaaa accgccattg gttggggatc acggtctagt agctaattat   600
ttacttgttt caattgtgct ggtagctact atcagtttga ctaagaaaat cttagaattc   660
tttttagctc aagaagcaga aaaaatgatt gcaaaggaag ct                      702

<210>   3432
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903555 (e-135)

<400>   3432
Met Asn Leu Trp Asp Ile Phe Phe Thr Thr Gln Ala Thr Glu Pro Pro 
1               5                   10                  15      

Lys Phe Asp Leu Phe Trp Tyr Val Ser Leu Phe Thr Leu Leu Ala Leu 
            20                  25                  30          

Thr Phe Tyr Thr Ala His Arg Tyr Arg Glu Lys Lys Val Tyr Gln Arg 
        35                  40                  45              

Phe Phe Gln Ile Leu Gln Thr Val Gln Leu Ile Leu Leu Tyr Gly Trp 
    50                  55                  60                  

Tyr Trp Val Asn His Met Pro Leu Ser Glu Ser Leu Pro Phe Tyr His 
65                  70                  75                  80  

Cys Arg Met Ala Met Phe Val Val Leu Leu Leu Pro Gly Gln Ser Lys 
                85                  90                  95      

Tyr Lys Gln Tyr Phe Ala Leu Leu Gly Thr Phe Gly Thr Leu Ala Ala 
            100                 105                 110         

Phe Val Tyr Pro Val Pro Asp Ala Tyr Pro Phe Pro His Ile Thr Ile 
        115                 120                 125             

Leu Ser Phe Ile Phe Gly His Leu Ala Leu Leu Gly Asn Ser Leu Val 
    130                 135                 140                 

Tyr Leu Leu Arg Gln Tyr Asn Ala Arg Leu Leu Asp Val Lys Gly Ile 
145                 150                 155                 160 

Phe Leu Met Thr Phe Ala Leu Asn Ala Leu Ile Phe Val Val Asn Leu 
                165                 170                 175     

Val Thr Gly Gly Asp Tyr Gly Phe Leu Thr Lys Pro Pro Leu Val Gly 
            180                 185                 190         

Asp His Gly Leu Val Ala Asn Tyr Leu Leu Val Ser Ile Val Leu Val 
        195                 200                 205             

Ala Thr Ile Ser Leu Thr Lys Lys Ile Leu Glu Phe Phe Leu Ala Gln 
    210                 215                 220                 


Glu Ala Glu Lys Met Ile Ala Lys Glu Ala 
225                 230                 

<210>   3433
<211>   609
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3433
atgaagacaa gtgattttgt caagtatttg caaagaatga ttgccattac agatactggc   60
ttaaccttta caaaagatcc gtttgaccgt gagcgctacg aagacttgcg aagtctgtta   120
tctgaaatgt tgaatcaagc atcagacctt gattccgaag aagtggcaga agtcttgaag   180
ccaacttctg cttatgcgac tccgttaatg gacgtccgtg cttggattgt tgaggatgag   240
aagatttgtc tggttagggg acaaggagag gatagttggg ctttgccagg tggctttggt   300
gaagtcggct attctccaac agaaaatatt ctcaaggaaa ttgaagaaga aaccggtttt   360
aaagccaaag ttgaaagact gctagctgtt tttgatacca atcgtttcca actacagagc   420
aaacagtata caaagtttgt ttttggatgt aagcttcttg atggacaatt ccaagaaaat   480
caagaaattg ctgaccttca attttttgcc attgaccaac tgccgaactt atctgaaaaa   540
cgcattacca aggagcaaat agagcttctt tggcaggttt atcaaggtca tagggggcaa   600
tatcttgac                                                           609

<210>   3434
<211>   203
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MutT/nudix family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903556 (e-112)

<400>   3434
Met Lys Thr Ser Asp Phe Val Lys Tyr Leu Gln Arg Met Ile Ala Ile 
1               5                   10                  15      

Thr Asp Thr Gly Leu Thr Phe Thr Lys Asp Pro Phe Asp Arg Glu Arg 
            20                  25                  30          

Tyr Glu Asp Leu Arg Ser Leu Leu Ser Glu Met Leu Asn Gln Ala Ser 
        35                  40                  45              

Asp Leu Asp Ser Glu Glu Val Ala Glu Val Leu Lys Pro Thr Ser Ala 
    50                  55                  60                  

Tyr Ala Thr Pro Leu Met Asp Val Arg Ala Trp Ile Val Glu Asp Glu 
65                  70                  75                  80  

Lys Ile Cys Leu Val Arg Gly Gln Gly Glu Asp Ser Trp Ala Leu Pro 
                85                  90                  95      

Gly Gly Phe Gly Glu Val Gly Tyr Ser Pro Thr Glu Asn Ile Leu Lys 
            100                 105                 110         

Glu Ile Glu Glu Glu Thr Gly Phe Lys Ala Lys Val Glu Arg Leu Leu 
        115                 120                 125             

Ala Val Phe Asp Thr Asn Arg Phe Gln Leu Gln Ser Lys Gln Tyr Thr 
    130                 135                 140                 

Lys Phe Val Phe Gly Cys Lys Leu Leu Asp Gly Gln Phe Gln Glu Asn 
145                 150                 155                 160 

Gln Glu Ile Ala Asp Leu Gln Phe Phe Ala Ile Asp Gln Leu Pro Asn 
                165                 170                 175     

Leu Ser Glu Lys Arg Ile Thr Lys Glu Gln Ile Glu Leu Leu Trp Gln 
            180                 185                 190         

Val Tyr Gln Gly His Arg Gly Gln Tyr Leu Asp 
        195                 200             


<210>   3435
<211>   1371
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3435
atgaaattaa caatccatga aattgcccaa gttgttggag ccaaaaatga tatcagtatc   60
tttgaggaca cccagttaga aaaagctgag tttgatagtc gtttgattgg aactggagat   120
ttatttgtgc cacttaaagg tgcgcgtgat ggccatgact ttattgaaac agcctttgaa   180
aatggtgcag cagtaacctt gtctgagaaa gaggtctcaa atcatcctta cattctagta   240
gatgatgttt tgacagcctt tcaatcctta gcatcctact atcttgaaaa aacgactgtt   300
gatgtctttg ctgttacagg ttcaaatggc aagacaacga ctaaggatat gttggcgcat   360
ttactgtcaa caagatacaa gacctacaaa acacaaggca attacaataa tgagattggc   420
cttccttaca cagttcttca tatgcctgaa ggaacagaaa agttggtttt ggagatggga   480
caggatcact tgggcgatat tcatctcttg tctgaattgg ctcgtccaaa aacagccatc   540
gtgaccttgg ttggagaagc ccatttggcc tttttcaaag accgttcaga gattgctaag   600
ggaaaaatgc aaattgcaga cggaatggct tcaggttcct tgcttttagc gccggctgac   660
cctatcgtag aggactattt gccaactgat aaaaaggtgg ttcgttttgg gcaaggggca   720
gagctggaaa ttactgactt ggttgagcgc aaagatagtc tgaccttcaa ggccaatttc   780
ttagagcaag cccttgattt gccagtaact ggcaagtaca atgcgacaaa tgctatgatt   840
gcatcctatg ttgccttgca agaaggagtt tcagaggagc aaattcgttt ggccttccaa   900
gatcttgaat tgacgcgtaa ccgtaccgag tggaagaaag cagccaatgg agcagatatc   960
ctgtcagatg tttacaatgc caatccaact gctatgaaac tgattttaga gactttctct   1020
gccattccag ccaatgaagg tggcaagaaa attgcagtgt tggcggatat gaaggagctt   1080
ggtgaccagt ctgttcaact tcataatcag atgattttga gcctttctcc agatgtgctt   1140
gataccgtga ttttctatgg agaaaatatt gctgaattag cccaattggc cagtcaaatg   1200
ttcccaatcg gccacgttta ctacttcaag aaaacagaag accaggatca atttgaagac   1260
ctagtcaagc aggtcaagga aagccttgga gcccatgacc aaatcctgct caaaggctct   1320
aactctatga atctagccaa gttggtagaa agtttagaaa atgaagacaa g            1371

<210>   3436
<211>   457
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-a
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903557 (0.E+01)

<400>   3436
Met Lys Leu Thr Ile His Glu Ile Ala Gln Val Val Gly Ala Lys Asn 
1               5                   10                  15      

Asp Ile Ser Ile Phe Glu Asp Thr Gln Leu Glu Lys Ala Glu Phe Asp 
            20                  25                  30          

Ser Arg Leu Ile Gly Thr Gly Asp Leu Phe Val Pro Leu Lys Gly Ala 
        35                  40                  45              

Arg Asp Gly His Asp Phe Ile Glu Thr Ala Phe Glu Asn Gly Ala Ala 
    50                  55                  60                  

Val Thr Leu Ser Glu Lys Glu Val Ser Asn His Pro Tyr Ile Leu Val 
65                  70                  75                  80  

Asp Asp Val Leu Thr Ala Phe Gln Ser Leu Ala Ser Tyr Tyr Leu Glu 
                85                  90                  95      

Lys Thr Thr Val Asp Val Phe Ala Val Thr Gly Ser Asn Gly Lys Thr 
            100                 105                 110         

Thr Thr Lys Asp Met Leu Ala His Leu Leu Ser Thr Arg Tyr Lys Thr 
        115                 120                 125             

Tyr Lys Thr Gln Gly Asn Tyr Asn Asn Glu Ile Gly Leu Pro Tyr Thr 
    130                 135                 140                 

Val Leu His Met Pro Glu Gly Thr Glu Lys Leu Val Leu Glu Met Gly 
145                 150                 155                 160 

Gln Asp His Leu Gly Asp Ile His Leu Leu Ser Glu Leu Ala Arg Pro 
                165                 170                 175     

Lys Thr Ala Ile Val Thr Leu Val Gly Glu Ala His Leu Ala Phe Phe 
            180                 185                 190         

Lys Asp Arg Ser Glu Ile Ala Lys Gly Lys Met Gln Ile Ala Asp Gly 
        195                 200                 205             

Met Ala Ser Gly Ser Leu Leu Leu Ala Pro Ala Asp Pro Ile Val Glu 
    210                 215                 220                 

Asp Tyr Leu Pro Thr Asp Lys Lys Val Val Arg Phe Gly Gln Gly Ala 
225                 230                 235                 240 

Glu Leu Glu Ile Thr Asp Leu Val Glu Arg Lys Asp Ser Leu Thr Phe 
                245                 250                 255     

Lys Ala Asn Phe Leu Glu Gln Ala Leu Asp Leu Pro Val Thr Gly Lys 
            260                 265                 270         

Tyr Asn Ala Thr Asn Ala Met Ile Ala Ser Tyr Val Ala Leu Gln Glu 
        275                 280                 285             

Gly Val Ser Glu Glu Gln Ile Arg Leu Ala Phe Gln Asp Leu Glu Leu 
    290                 295                 300                 

Thr Arg Asn Arg Thr Glu Trp Lys Lys Ala Ala Asn Gly Ala Asp Ile 
305                 310                 315                 320 

Leu Ser Asp Val Tyr Asn Ala Asn Pro Thr Ala Met Lys Leu Ile Leu 
                325                 330                 335     

Glu Thr Phe Ser Ala Ile Pro Ala Asn Glu Gly Gly Lys Lys Ile Ala 
            340                 345                 350         

Val Leu Ala Asp Met Lys Glu Leu Gly Asp Gln Ser Val Gln Leu His 
        355                 360                 365             

Asn Gln Met Ile Leu Ser Leu Ser Pro Asp Val Leu Asp Thr Val Ile 
    370                 375                 380                 

Phe Tyr Gly Glu Asn Ile Ala Glu Leu Ala Gln Leu Ala Ser Gln Met 
385                 390                 395                 400 

Phe Pro Ile Gly His Val Tyr Tyr Phe Lys Lys Thr Glu Asp Gln Asp 

                405                 410                 415     

Gln Phe Glu Asp Leu Val Lys Gln Val Lys Glu Ser Leu Gly Ala His 
            420                 425                 430         

Asp Gln Ile Leu Leu Lys Gly Ser Asn Ser Met Asn Leu Ala Lys Leu 
        435                 440                 445             

Val Glu Ser Leu Glu Asn Glu Asp Lys 
    450                 455         

<210>   3437
<211>   1041
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3437
atgaaacaaa cgattattct tttatatggt ggacggagtg cggaacgcga agtctctgtc   60
ctttcagctg agagtgtcat gcgtgcggtc gattacgacc gtttcacagt caagactttc   120
tttatcagtc agtcaggtga ctttatcaaa acacaggaat ttagtcatgc tccggggcaa   180
gaagaccgtc tcatgaccaa tgaaaccatt gattgggata agaaagttgc accaagtgct   240
atctacgaag aaggtgcagt ggtctttcca gtccttcacg ggccaatggg agaagatggc   300
tctgttcaag gattcttgga agttttgaaa atgccttacg ttggttgcaa cattttgtca   360
tcaagtcttg ccatggataa aatcacgact aagcgtgttc tggaatctgc tggtattgcc   420
caagttcctt atgtggctat cgttgaaggc gatgatgtga ctgctaaaat cgctgaagtg   480
gaagaaaaat tggcttatcc agtcttcact aagccgtcaa acatggggtc tagtgtcggt   540
atttctaagt ctgaaaacca agaagaactc cgtcaagcct taaaacttgc cttccgatat   600
gacagccgtg tcttggttga gcaaggagtg aatgcccgtg aaattgaggt tggcctcttg   660
ggtaactacg atgtcaagag cacgctacca ggagaagttg tcaaggacgt tgccttttat   720
gactacgatg ccaagtatat tgataacaat attactatgg atattcctgc caaaatcagt   780
gatgatgtgg tggctgtcat gcgtcaaaat gcagaaacag ccttccgtgc cattggtggc   840
cttggtctat ctcgttgcga tttcttctat acagataagg gagagatttt tctcaacgag   900
ctcaatacta tgccaggttt cacccagtgg tctatgtacc cactactttg ggacaatatg   960
gggatcagct acccaaaact aatcgagcgt ttggttgacc ttgccaagga aagttttgac   1020
aagcgcgaag cgcatttgat a                                             1041

<210>   3438
<211>   347
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   D-alanine--D-alanine ligase (ddlA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903558 (0.E+01)

<400>   3438
Met Lys Gln Thr Ile Ile Leu Leu Tyr Gly Gly Arg Ser Ala Glu Arg 
1               5                   10                  15      

Glu Val Ser Val Leu Ser Ala Glu Ser Val Met Arg Ala Val Asp Tyr 
            20                  25                  30          

Asp Arg Phe Thr Val Lys Thr Phe Phe Ile Ser Gln Ser Gly Asp Phe 
        35                  40                  45              

Ile Lys Thr Gln Glu Phe Ser His Ala Pro Gly Gln Glu Asp Arg Leu 
    50                  55                  60                  

Met Thr Asn Glu Thr Ile Asp Trp Asp Lys Lys Val Ala Pro Ser Ala 
65                  70                  75                  80  

Ile Tyr Glu Glu Gly Ala Val Val Phe Pro Val Leu His Gly Pro Met 
                85                  90                  95      

Gly Glu Asp Gly Ser Val Gln Gly Phe Leu Glu Val Leu Lys Met Pro 
            100                 105                 110         

Tyr Val Gly Cys Asn Ile Leu Ser Ser Ser Leu Ala Met Asp Lys Ile 
        115                 120                 125             

Thr Thr Lys Arg Val Leu Glu Ser Ala Gly Ile Ala Gln Val Pro Tyr 
    130                 135                 140                 

Val Ala Ile Val Glu Gly Asp Asp Val Thr Ala Lys Ile Ala Glu Val 
145                 150                 155                 160 

Glu Glu Lys Leu Ala Tyr Pro Val Phe Thr Lys Pro Ser Asn Met Gly 
                165                 170                 175     

Ser Ser Val Gly Ile Ser Lys Ser Glu Asn Gln Glu Glu Leu Arg Gln 
            180                 185                 190         

Ala Leu Lys Leu Ala Phe Arg Tyr Asp Ser Arg Val Leu Val Glu Gln 
        195                 200                 205             

Gly Val Asn Ala Arg Glu Ile Glu Val Gly Leu Leu Gly Asn Tyr Asp 
    210                 215                 220                 

Val Lys Ser Thr Leu Pro Gly Glu Val Val Lys Asp Val Ala Phe Tyr 
225                 230                 235                 240 

Asp Tyr Asp Ala Lys Tyr Ile Asp Asn Asn Ile Thr Met Asp Ile Pro 
                245                 250                 255     

Ala Lys Ile Ser Asp Asp Val Val Ala Val Met Arg Gln Asn Ala Glu 
            260                 265                 270         

Thr Ala Phe Arg Ala Ile Gly Gly Leu Gly Leu Ser Arg Cys Asp Phe 
        275                 280                 285             

Phe Tyr Thr Asp Lys Gly Glu Ile Phe Leu Asn Glu Leu Asn Thr Met 
    290                 295                 300                 

Pro Gly Phe Thr Gln Trp Ser Met Tyr Pro Leu Leu Trp Asp Asn Met 
305                 310                 315                 320 

Gly Ile Ser Tyr Pro Lys Leu Ile Glu Arg Leu Val Asp Leu Ala Lys 
                325                 330                 335     

Glu Ser Phe Asp Lys Arg Glu Ala His Leu Ile 
            340                 345         

<210>   3439
<211>   594
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3439
atgctttatc caacacctat tgccaagttg attgacagtt attctaagtt accaggtatc   60
gggattaaga cggctacgcg tctggccttt tatacgattg ggatgtctgc tgatgatgtc   120
aatgaatttg caaaaaatct cctttctgct aagagagaat tgacatattg ttctatttgt   180
ggacgtttga cagacgacga tccttgttct atctgtactg atccgactcg tgaccagaca   240
acaattttag ttcttgagga tagtagagat gtggcagcca tggaaaatat ccaagaatac   300
catggactct atcatgtcct tcatggcctc atttctccta tgaatggtat cagtccggac   360
gatatcaatc tcaagagcct tatgactcgt cttatggata gtgaggtttc agaagtgatt   420
gtggcgacta atgctacagc ggatggtgaa gcgacttcca tgtatctttc acgtttgctc   480
aagccggctg gtatcaaggt tacgcgtcta gcacgaggtc tcgctgtggg agcggacatt   540
gagtatgcgg acgaagtgac actcttacga gccattgaaa atcggacaga gttg         594

<210>   3440
<211>   198
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   recombination protein RecR (recR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903559 (e-110)

<400>   3440
Met Leu Tyr Pro Thr Pro Ile Ala Lys Leu Ile Asp Ser Tyr Ser Lys 
1               5                   10                  15      

Leu Pro Gly Ile Gly Ile Lys Thr Ala Thr Arg Leu Ala Phe Tyr Thr 
            20                  25                  30          

Ile Gly Met Ser Ala Asp Asp Val Asn Glu Phe Ala Lys Asn Leu Leu 
        35                  40                  45              

Ser Ala Lys Arg Glu Leu Thr Tyr Cys Ser Ile Cys Gly Arg Leu Thr 
    50                  55                  60                  

Asp Asp Asp Pro Cys Ser Ile Cys Thr Asp Pro Thr Arg Asp Gln Thr 
65                  70                  75                  80  

Thr Ile Leu Val Leu Glu Asp Ser Arg Asp Val Ala Ala Met Glu Asn 
                85                  90                  95      

Ile Gln Glu Tyr His Gly Leu Tyr His Val Leu His Gly Leu Ile Ser 
            100                 105                 110         

Pro Met Asn Gly Ile Ser Pro Asp Asp Ile Asn Leu Lys Ser Leu Met 
        115                 120                 125             

Thr Arg Leu Met Asp Ser Glu Val Ser Glu Val Ile Val Ala Thr Asn 
    130                 135                 140                 

Ala Thr Ala Asp Gly Glu Ala Thr Ser Met Tyr Leu Ser Arg Leu Leu 
145                 150                 155                 160 

Lys Pro Ala Gly Ile Lys Val Thr Arg Leu Ala Arg Gly Leu Ala Val 
                165                 170                 175     

Gly Ala Asp Ile Glu Tyr Ala Asp Glu Val Thr Leu Leu Arg Ala Ile 
            180                 185                 190         

Glu Asn Arg Thr Glu Leu 
        195             

<210>   3441
<211>   2055
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3441
atgagactga tttgtatgag aaaatttaac agccattcga ttccgattcg gcttaattta   60
ttgttttcaa tcgtcatttt actctttatg accattattg gtcgtttgtt gtatatgcag   120
gttttgaaca aggattttta cgaaaaaaag ctagcttcag ctagtcagac caagattaca   180
agcagttcag cccgtgggga aatttatgat gctagtggaa aacctttggt agaaaatacg   240
ttaaagcagg ttgtttcctt tacgcgtagc aataaaatga cggctacaga cttaaaagaa   300
acagctaaaa agttactgac ttatgtgagc atcagttctc caaatttgac agaacgccag   360
ctggcggatt actatttggc tgatcctgaa atctataaaa aaatagtgga agctctccca   420
agtgagaaac gcttggattc agatggcaat cgtctatccg aatcagaact gtataacaat   480
gcggtcgata gtgtacaaac gagtcaacta aactatacag aggatgaaaa gaaagaaatc   540
tatcttttta gtcagttaaa tgctgttgga aactttgcga caggaaccat tgcgacagat   600
cctctaaatg attctcaggt ggctgttatt gcctctattt caaaggagat gcctggcatt   660
agtatttcta cttcttggga tagaaaggtt ttggaaactt ccctttcttc tatagttggg   720
agtgtatcca gtgaaaaagc tggtctccca gcggaagaag cagaagccta tcttaaaaaa   780
ggctattctc taaatgaccg tgtaggaacc tcctatttgg aaaagcaata tgaagagacc   840
ttacaaggaa aacgctcggt aaaagaaatc catctggata aatatggcaa tatggaaagc   900
gtggatacaa ttgaggaagg tagtaaggga aacaatatca aactgaccat tgatttggct   960
ttccaagata gcgtggatgc tttactgaaa agttatttca attctgagct agaaaatggt   1020
ggagccaagt attctgaagg tgtctatgca gtcgccctta acccaaaaac aggtgcggtt   1080
ttgtctatgt cagggattaa acatgacttg aaaacgggag agttgacgcc tgattccttg   1140
ggaacggtaa ccaatgtctt tgttccaggt tcggttgtca aggcggcgac catcagctca   1200
ggttgggaaa atggagtctt gtcaggaaac cagaccttga cagaccagtc cattgtcttc   1260
caaggttcag ctcccatcaa ttcttggtat actcaggctt acggttcatt ccctatcaca   1320
gcggtccaag ctctggagta ttcatcaaat acctatatgg tccaaacagc cttaggtctt   1380
atggggcaaa cctatcaacc caatatgttt gtcggcacca gcaatctaga gtctgctatg   1440
gagaaactgc gttcaacctt tggcgaatat ggcttgggta ctgcgacagg aattgaccta   1500
ccagatgaat ctactggatt tgttcccaaa gagtatagct ttgctaatta cattactaat   1560
gcctttgggc agtttgataa ctatacgccg atgcagttgg ctcagtatgt agcaactatt   1620
gcaaataatg gtgttcgtgt ggctcctcgt attgttgaag gcatttatgg taataatgat   1680
aagggaggac tgggtgactt gattcagcaa ctgcaaccga cagagatgaa taaggtcaat   1740
atatccgact ccgatatgag catcttgcac caaggttttt atcaggttgc ccatggtact   1800
agtggattga caactggacg tgccttttca aatggtgcct tggtatccat tagcggaaaa   1860
acaggtacag ccgaaagcta tgtggcagat ggtcagcaag caaccaatac caatgcggtg   1920
gcctatgccc catctgataa tccccaaatc gctgtcgcag tggtctttcc tcataatacc   1980
aatctaacaa atggtgtagg accttccatt gcgcgtgaca ttatcaatct gtatcaaaaa   2040
taccatccaa tgaat                                                    2055

<210>   3442
<211>   685
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   penicillin-binding protein 2B (penA)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903560 (0.E+01)

<400>   3442
Met Arg Leu Ile Cys Met Arg Lys Phe Asn Ser His Ser Ile Pro Ile 
1               5                   10                  15      

Arg Leu Asn Leu Leu Phe Ser Ile Val Ile Leu Leu Phe Met Thr Ile 
            20                  25                  30          

Ile Gly Arg Leu Leu Tyr Met Gln Val Leu Asn Lys Asp Phe Tyr Glu 
        35                  40                  45              

Lys Lys Leu Ala Ser Ala Ser Gln Thr Lys Ile Thr Ser Ser Ser Ala 
    50                  55                  60                  

Arg Gly Glu Ile Tyr Asp Ala Ser Gly Lys Pro Leu Val Glu Asn Thr 
65                  70                  75                  80  

Leu Lys Gln Val Val Ser Phe Thr Arg Ser Asn Lys Met Thr Ala Thr 
                85                  90                  95      

Asp Leu Lys Glu Thr Ala Lys Lys Leu Leu Thr Tyr Val Ser Ile Ser 
            100                 105                 110         

Ser Pro Asn Leu Thr Glu Arg Gln Leu Ala Asp Tyr Tyr Leu Ala Asp 
        115                 120                 125             

Pro Glu Ile Tyr Lys Lys Ile Val Glu Ala Leu Pro Ser Glu Lys Arg 
    130                 135                 140                 

Leu Asp Ser Asp Gly Asn Arg Leu Ser Glu Ser Glu Leu Tyr Asn Asn 
145                 150                 155                 160 

Ala Val Asp Ser Val Gln Thr Ser Gln Leu Asn Tyr Thr Glu Asp Glu 
                165                 170                 175     

Lys Lys Glu Ile Tyr Leu Phe Ser Gln Leu Asn Ala Val Gly Asn Phe 
            180                 185                 190         

Ala Thr Gly Thr Ile Ala Thr Asp Pro Leu Asn Asp Ser Gln Val Ala 
        195                 200                 205             

Val Ile Ala Ser Ile Ser Lys Glu Met Pro Gly Ile Ser Ile Ser Thr 
    210                 215                 220                 

Ser Trp Asp Arg Lys Val Leu Glu Thr Ser Leu Ser Ser Ile Val Gly 
225                 230                 235                 240 

Ser Val Ser Ser Glu Lys Ala Gly Leu Pro Ala Glu Glu Ala Glu Ala 
                245                 250                 255     

Tyr Leu Lys Lys Gly Tyr Ser Leu Asn Asp Arg Val Gly Thr Ser Tyr 
            260                 265                 270         

Leu Glu Lys Gln Tyr Glu Glu Thr Leu Gln Gly Lys Arg Ser Val Lys 
        275                 280                 285             

Glu Ile His Leu Asp Lys Tyr Gly Asn Met Glu Ser Val Asp Thr Ile 
    290                 295                 300                 

Glu Glu Gly Ser Lys Gly Asn Asn Ile Lys Leu Thr Ile Asp Leu Ala 
305                 310                 315                 320 

Phe Gln Asp Ser Val Asp Ala Leu Leu Lys Ser Tyr Phe Asn Ser Glu 
                325                 330                 335     

Leu Glu Asn Gly Gly Ala Lys Tyr Ser Glu Gly Val Tyr Ala Val Ala 
            340                 345                 350         

Leu Asn Pro Lys Thr Gly Ala Val Leu Ser Met Ser Gly Ile Lys His 
        355                 360                 365             

Asp Leu Lys Thr Gly Glu Leu Thr Pro Asp Ser Leu Gly Thr Val Thr 
    370                 375                 380                 

Asn Val Phe Val Pro Gly Ser Val Val Lys Ala Ala Thr Ile Ser Ser 
385                 390                 395                 400 

Gly Trp Glu Asn Gly Val Leu Ser Gly Asn Gln Thr Leu Thr Asp Gln 
                405                 410                 415     

Ser Ile Val Phe Gln Gly Ser Ala Pro Ile Asn Ser Trp Tyr Thr Gln 
            420                 425                 430         

Ala Tyr Gly Ser Phe Pro Ile Thr Ala Val Gln Ala Leu Glu Tyr Ser 
        435                 440                 445             

Ser Asn Thr Tyr Met Val Gln Thr Ala Leu Gly Leu Met Gly Gln Thr 
    450                 455                 460                 

Tyr Gln Pro Asn Met Phe Val Gly Thr Ser Asn Leu Glu Ser Ala Met 
465                 470                 475                 480 

Glu Lys Leu Arg Ser Thr Phe Gly Glu Tyr Gly Leu Gly Thr Ala Thr 
                485                 490                 495     

Gly Ile Asp Leu Pro Asp Glu Ser Thr Gly Phe Val Pro Lys Glu Tyr 
            500                 505                 510         

Ser Phe Ala Asn Tyr Ile Thr Asn Ala Phe Gly Gln Phe Asp Asn Tyr 
        515                 520                 525             

Thr Pro Met Gln Leu Ala Gln Tyr Val Ala Thr Ile Ala Asn Asn Gly 
    530                 535                 540                 

Val Arg Val Ala Pro Arg Ile Val Glu Gly Ile Tyr Gly Asn Asn Asp 
545                 550                 555                 560 

Lys Gly Gly Leu Gly Asp Leu Ile Gln Gln Leu Gln Pro Thr Glu Met 
                565                 570                 575     

Asn Lys Val Asn Ile Ser Asp Ser Asp Met Ser Ile Leu His Gln Gly 
            580                 585                 590         

Phe Tyr Gln Val Ala His Gly Thr Ser Gly Leu Thr Thr Gly Arg Ala 
        595                 600                 605             

Phe Ser Asn Gly Ala Leu Val Ser Ile Ser Gly Lys Thr Gly Thr Ala 
    610                 615                 620                 

Glu Ser Tyr Val Ala Asp Gly Gln Gln Ala Thr Asn Thr Asn Ala Val 
625                 630                 635                 640 

Ala Tyr Ala Pro Ser Asp Asn Pro Gln Ile Ala Val Ala Val Val Phe 
                645                 650                 655     

Pro His Asn Thr Asn Leu Thr Asn Gly Val Gly Pro Ser Ile Ala Arg 
            660                 665                 670         

Asp Ile Ile Asn Leu Tyr Gln Lys Tyr His Pro Met Asn 
        675                 680                 685 

<210>   3443
<211>   849
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3443
atggacaaac cagatatcgc aactatcatt gattcacatt ttgaagaaat gacagaccta   60
gaacaagaaa tcgctcgcta ttttttgcaa gctgaaacga ttacagatga tttatcttct   120
caacaagtca cccaaaaatt acatatttct caagctgctt tgacccgctt tgctaaaaag   180
tgtggcttta ctggctaccg agaatttatt ttccaatacc aacatcaggc agaaaatcaa   240
gccaaccaag tctccaagca cagtccactg accaaacgag tcctcagaag ttatagcaat   300
atgagggaac aaacacaaga cttgattgac gaaatccaac tagaacgaat tgcccagcta   360
atcgaagatg ctgagcgtat ctacttcttt ggaacaggga gttctggcct cgtcgcccgt   420
gaaatgaaat tacgttttat gcgactaggt gtggtctgcg aagctttgac agaccaagac   480
ggctttgcct ggacaaccag catcatggat gaaaattgtc tagtactggg cttctcactt   540
tcaggctcaa ctccttctat tttagatagt ctattagatg ctaaggagat gggggcaaag   600
actgtactct ttacaagtgt tcccaataaa gatagccaga cctatacaga gactgttctt   660
gtagccaccc acagccaacc ctcctatatc caacgaatat ccgctcaact tcctatgctc   720
ttctttatcg atttgattta tgcctacttt ttggaaatca atcgcgaaag caaggaaaaa   780
atctttaata gctactggga aaataaaaaa ctcaacggct atcgtagaca aaaacgtgta   840
agaaaatcc                                                           849

<210>   3444
<211>   283
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphosugar-binding transcriptional regulator, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903561 (e-159)

<400>   3444
Met Asp Lys Pro Asp Ile Ala Thr Ile Ile Asp Ser His Phe Glu Glu 
1               5                   10                  15      

Met Thr Asp Leu Glu Gln Glu Ile Ala Arg Tyr Phe Leu Gln Ala Glu 
            20                  25                  30          


Thr Ile Thr Asp Asp Leu Ser Ser Gln Gln Val Thr Gln Lys Leu His 
        35                  40                  45              

Ile Ser Gln Ala Ala Leu Thr Arg Phe Ala Lys Lys Cys Gly Phe Thr 
    50                  55                  60                  

Gly Tyr Arg Glu Phe Ile Phe Gln Tyr Gln His Gln Ala Glu Asn Gln 
65                  70                  75                  80  

Ala Asn Gln Val Ser Lys His Ser Pro Leu Thr Lys Arg Val Leu Arg 
                85                  90                  95      

Ser Tyr Ser Asn Met Arg Glu Gln Thr Gln Asp Leu Ile Asp Glu Ile 
            100                 105                 110         

Gln Leu Glu Arg Ile Ala Gln Leu Ile Glu Asp Ala Glu Arg Ile Tyr 
        115                 120                 125             

Phe Phe Gly Thr Gly Ser Ser Gly Leu Val Ala Arg Glu Met Lys Leu 
    130                 135                 140                 

Arg Phe Met Arg Leu Gly Val Val Cys Glu Ala Leu Thr Asp Gln Asp 
145                 150                 155                 160 

Gly Phe Ala Trp Thr Thr Ser Ile Met Asp Glu Asn Cys Leu Val Leu 
                165                 170                 175     

Gly Phe Ser Leu Ser Gly Ser Thr Pro Ser Ile Leu Asp Ser Leu Leu 
            180                 185                 190         

Asp Ala Lys Glu Met Gly Ala Lys Thr Val Leu Phe Thr Ser Val Pro 
        195                 200                 205             

Asn Lys Asp Ser Gln Thr Tyr Thr Glu Thr Val Leu Val Ala Thr His 
    210                 215                 220                 

Ser Gln Pro Ser Tyr Ile Gln Arg Ile Ser Ala Gln Leu Pro Met Leu 
225                 230                 235                 240 

Phe Phe Ile Asp Leu Ile Tyr Ala Tyr Phe Leu Glu Ile Asn Arg Glu 
                245                 250                 255     

Ser Lys Glu Lys Ile Phe Asn Ser Tyr Trp Glu Asn Lys Lys Leu Asn 
            260                 265                 270         

Gly Tyr Arg Arg Gln Lys Arg Val Arg Lys Ser 
        275                 280             

<210>   3445
<211>   882
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3445
atgacatatt acgttgcaat tgatatcggt ggaaccaaca tcaagtatgg tttggttgat   60
caagaggggc aacttcttga atcgcatgaa atgccaactg aggcgcataa gggtggacct   120
catatcttac aaaagaccaa agatatcgta gctagttatt tagaaaaagg cccagtagca   180
ggtgttgcca tatcttctgc tgggatggtg gatccggata agggtgagat tttctatgct   240
gggccgcaaa tccctaacta cgcaggcacc cagttcaaaa aggaaatcga agaaagcttt   300

actattcctt gtgagattga aaatgatgtc aactgtgcag gtcttgctga ggcagtatct   360
ggttcaggca agggagcaag tgtgacactt tgcttgacca ttggaaccgg tatcggtggt   420
tgcttgatta tggataggaa agtcttccat ggttttagca attcagcctg tgaagtcggg   480
tatatgcata tgcaggatgg agcttttcaa gacttggctt ctacaacagc tttagtgaaa   540
tatgtagctg aagcccatgg agaagatgtt gatcagtgga atggccgtag aattttcaaa   600
gaagccactg aaggaaacaa aatctgcatg gaaggtattg accgtatggt tgactatcta   660
ggaaaaggtc tggcaaatat ttgctacgtt gccaatccag aagtggttat tcttggtggt   720
ggtatcatgg ggcaagaggc tatcctcaaa cctaagatcc gtacagcctt gaaagaggct   780
ttggtaccaa gtttagcaga aaaaacacga ttagaatttg cccatcacca aaatacagca   840
gggatgttgg gtgcatatta tcattttaag acaaaacaat cc                      882

<210>   3446
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ROK family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903562 (e-172)

<400>   3446
Met Thr Tyr Tyr Val Ala Ile Asp Ile Gly Gly Thr Asn Ile Lys Tyr 
1               5                   10                  15      

Gly Leu Val Asp Gln Glu Gly Gln Leu Leu Glu Ser His Glu Met Pro 
            20                  25                  30          

Thr Glu Ala His Lys Gly Gly Pro His Ile Leu Gln Lys Thr Lys Asp 
        35                  40                  45              

Ile Val Ala Ser Tyr Leu Glu Lys Gly Pro Val Ala Gly Val Ala Ile 
    50                  55                  60                  

Ser Ser Ala Gly Met Val Asp Pro Asp Lys Gly Glu Ile Phe Tyr Ala 
65                  70                  75                  80  

Gly Pro Gln Ile Pro Asn Tyr Ala Gly Thr Gln Phe Lys Lys Glu Ile 
                85                  90                  95      

Glu Glu Ser Phe Thr Ile Pro Cys Glu Ile Glu Asn Asp Val Asn Cys 
            100                 105                 110         

Ala Gly Leu Ala Glu Ala Val Ser Gly Ser Gly Lys Gly Ala Ser Val 
        115                 120                 125             

Thr Leu Cys Leu Thr Ile Gly Thr Gly Ile Gly Gly Cys Leu Ile Met 
    130                 135                 140                 

Asp Arg Lys Val Phe His Gly Phe Ser Asn Ser Ala Cys Glu Val Gly 
145                 150                 155                 160 

Tyr Met His Met Gln Asp Gly Ala Phe Gln Asp Leu Ala Ser Thr Thr 
                165                 170                 175     

Ala Leu Val Lys Tyr Val Ala Glu Ala His Gly Glu Asp Val Asp Gln 
            180                 185                 190         

Trp Asn Gly Arg Arg Ile Phe Lys Glu Ala Thr Glu Gly Asn Lys Ile 
        195                 200                 205             

Cys Met Glu Gly Ile Asp Arg Met Val Asp Tyr Leu Gly Lys Gly Leu 
    210                 215                 220                 

Ala Asn Ile Cys Tyr Val Ala Asn Pro Glu Val Val Ile Leu Gly Gly 
225                 230                 235                 240 

Gly Ile Met Gly Gln Glu Ala Ile Leu Lys Pro Lys Ile Arg Thr Ala 
                245                 250                 255     

Leu Lys Glu Ala Leu Val Pro Ser Leu Ala Glu Lys Thr Arg Leu Glu 
            260                 265                 270         

Phe Ala His His Gln Asn Thr Ala Gly Met Leu Gly Ala Tyr Tyr His 
        275                 280                 285             

Phe Lys Thr Lys Gln Ser 
    290                 

<210>   3447
<211>   690
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3447
ttgaccatta ttgcccatgt tgcttgcaat aatactaaag atagtatgga acttgctcgc   60
catgctgaaa gcttgggagt agatgctatt gcaacgattc caccaattta tttccgcttg   120
ccagaatact cagttgccaa atactggaac gatatcagtt ctgcagctcc aaacacagac   180
tacgtgattt acaacattcc tcaattggca ggggttgctt tgactccaag cctttacaca   240
gaaatgttga aaaatcctcg tgttatcggt gtgaagaact cttctatgcc agttcaagat   300
atccaaacct ttgtcagcct tggtggagaa gaccatatcg tctttaatgg tcctgatgag   360
cagttcctag gaggacgcct catgggggct agggctggta tcggtggtac ttatggtgct   420
atgccagaac tcttcttgaa actcaatcag ttgattgcgg ataaggacct agaaacagcg   480
cgtgaattgc agtatgctat caacgcaatc attggtaaac tcacttctgc tcatggaaat   540
atgtacggtg tcatcaaaga agtcttgaaa atcaatgaag gcttgaatat tggatctgtt   600
cgttcaccat tgacaccagt gactgaagaa gatcgtccag ttgtagaagc ggctgctgcc   660
ttgattcgtg aaaccaagga gcgcttcctc                                    690

<210>   3448
<211>   230
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   putative acylneuraminate lyase

<400>   3448
Met Thr Ile Ile Ala His Val Ala Cys Asn Asn Thr Lys Asp Ser Met 
1               5                   10                  15      

Glu Leu Ala Arg His Ala Glu Ser Leu Gly Val Asp Ala Ile Ala Thr 
            20                  25                  30          

Ile Pro Pro Ile Tyr Phe Arg Leu Pro Glu Tyr Ser Val Ala Lys Tyr 
        35                  40                  45              

Trp Asn Asp Ile Ser Ser Ala Ala Pro Asn Thr Asp Tyr Val Ile Tyr 
    50                  55                  60                  

Asn Ile Pro Gln Leu Ala Gly Val Ala Leu Thr Pro Ser Leu Tyr Thr 
65                  70                  75                  80  

Glu Met Leu Lys Asn Pro Arg Val Ile Gly Val Lys Asn Ser Ser Met 
                85                  90                  95      

Pro Val Gln Asp Ile Gln Thr Phe Val Ser Leu Gly Gly Glu Asp His 
            100                 105                 110         

Ile Val Phe Asn Gly Pro Asp Glu Gln Phe Leu Gly Gly Arg Leu Met 
        115                 120                 125             

Gly Ala Arg Ala Gly Ile Gly Gly Thr Tyr Gly Ala Met Pro Glu Leu 
    130                 135                 140                 

Phe Leu Lys Leu Asn Gln Leu Ile Ala Asp Lys Asp Leu Glu Thr Ala 
145                 150                 155                 160 

Arg Glu Leu Gln Tyr Ala Ile Asn Ala Ile Ile Gly Lys Leu Thr Ser 
                165                 170                 175     

Ala His Gly Asn Met Tyr Gly Val Ile Lys Glu Val Leu Lys Ile Asn 
            180                 185                 190         

Glu Gly Leu Asn Ile Gly Ser Val Arg Ser Pro Leu Thr Pro Val Thr 
        195                 200                 205             

Glu Glu Asp Arg Pro Val Val Glu Ala Ala Ala Ala Leu Ile Arg Glu 
    210                 215                 220                 

Thr Lys Glu Arg Phe Leu 
225                 230 

<210>   3449
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3449
atgtcagatt tgaaaaaata cgaaggtgtc attccagcct tctacgcatg ttatgatgat   60
caaggagaag taagcccaga acgtacgcgt gccttggttc aatacttcat tgataaaggt   120
gttcaaggtc tttatgtcaa tggttcttct ggtgaatgta tctaccaaag cgttgaagat   180
cgcaagttga ttttggaaga agtcatggcg gtagcaaagg taaat                   225

<210>   3450
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   N-acetylneuraminate lyase, putative, FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903229 (e-134)

<400>   3450
Met Ser Asp Leu Lys Lys Tyr Glu Gly Val Ile Pro Ala Phe Tyr Ala 
1               5                   10                  15      

Cys Tyr Asp Asp Gln Gly Glu Val Ser Pro Glu Arg Thr Arg Ala Leu 
            20                  25                  30          

Val Gln Tyr Phe Ile Asp Lys Gly Val Gln Gly Leu Tyr Val Asn Gly 
        35                  40                  45              

Ser Ser Gly Glu Cys Ile Tyr Gln Ser Val Glu Asp Arg Lys Leu Ile 
    50                  55                  60                  

Leu Glu Glu Val Met Ala Val Ala Lys Val Asn 
65                  70                  75  

<210>   3451
<211>   642
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3451
atggcacaaa aaggagtaag ccttatcaag gcagcatttg atacagataa ctttctcatg   60
cgttttagtg agaaggtctt ggacatcgtg acagccaatc ttctttttgt cgtctcttgt   120
ttacccatcg tgacgattgg agtggctaaa atcagcctct acgagaccat gttcgaagtt   180
aagaagagca gacgggtgcc tgtttttaaa atctatctaa gatctttcaa gcaaaatctg   240
aaactaggtc ttcagctggg tttaatggag ttaggaattg tgtttcttac cctttcagat   300
ctctatcttt tctggggtca aacagctctg cccttccaat tgctgaaagc catttgttta   360
ggtattctga tttttcttac tatcgtgatg ctggctagtt accctatcgc ggcacgttat   420
gacctatctt ggaaagaaat tcttcaaaaa ggattgatgt tggctagttt taactttcct   480
tggttcttcc tcatgttagc cattcttgtc ctcattgtga tggttcttta tctgtccgcc   540
ttcagtctac tcttaggtgg ctcagtcttc ctactttttg ggtttggact attggtcttt   600
atccagactg gattgatgga gaaaattttc gcaaaatacc aa                      642

<210>   3452
<211>   214
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903565 (1.E-71)

<400>   3452
Met Ala Gln Lys Gly Val Ser Leu Ile Lys Ala Ala Phe Asp Thr Asp 
1               5                   10                  15      

Asn Phe Leu Met Arg Phe Ser Glu Lys Val Leu Asp Ile Val Thr Ala 
            20                  25                  30          

Asn Leu Leu Phe Val Val Ser Cys Leu Pro Ile Val Thr Ile Gly Val 
        35                  40                  45              

Ala Lys Ile Ser Leu Tyr Glu Thr Met Phe Glu Val Lys Lys Ser Arg 
    50                  55                  60                  

Arg Val Pro Val Phe Lys Ile Tyr Leu Arg Ser Phe Lys Gln Asn Leu 
65                  70                  75                  80  

Lys Leu Gly Leu Gln Leu Gly Leu Met Glu Leu Gly Ile Val Phe Leu 
                85                  90                  95      

Thr Leu Ser Asp Leu Tyr Leu Phe Trp Gly Gln Thr Ala Leu Pro Phe 
            100                 105                 110         

Gln Leu Leu Lys Ala Ile Cys Leu Gly Ile Leu Ile Phe Leu Thr Ile 
        115                 120                 125             

Val Met Leu Ala Ser Tyr Pro Ile Ala Ala Arg Tyr Asp Leu Ser Trp 
    130                 135                 140                 

Lys Glu Ile Leu Gln Lys Gly Leu Met Leu Ala Ser Phe Asn Phe Pro 
145                 150                 155                 160 

Trp Phe Phe Leu Met Leu Ala Ile Leu Val Leu Ile Val Met Val Leu 
                165                 170                 175     

Tyr Leu Ser Ala Phe Ser Leu Leu Leu Gly Gly Ser Val Phe Leu Leu 
            180                 185                 190         

Phe Gly Phe Gly Leu Leu Val Phe Ile Gln Thr Gly Leu Met Glu Lys 
        195                 200                 205             

Ile Phe Ala Lys Tyr Gln 
    210                 

<210>   3453
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3453
ttgttcatgg tagggactta tgaaagcttt actgacaaaa aagaaaacag tttacaaaga   60
aaaatgatgg aggagcaaac atggcacaaa aaggag                             96

<210>   3454
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3454
Met Phe Met Val Gly Thr Tyr Glu Ser Phe Thr Asp Lys Lys Glu Asn 
1               5                   10                  15      

Ser Leu Gln Arg Lys Met Met Glu Glu Gln Thr Trp His Lys Lys Glu 
            20                  25                  30          


<210>   3455
<211>   342

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3455
ttggtatctt ctaagtatgc tgcaagagct agtttcttag atggacaggg gattacagtt   60
gatgagatgg cttggataat taggggcatt gtgaatgcat tgattggtag atacataaaa   120
ttaggtactt atgcggctaa gtatggtatt agtatggcac gctcgatctt aagtagggta   180
gctgcaactg cagcagcaag agtaggatta ctgaccaaga tttctggatg gattttacga   240
gtagctgtga atgtagctga tgtatatggt aattttgcca acaatattgc tgcagcttgg   300
gatgcatatg ataaaattcc taacaatggt cgtataaact tt                      342

<210>   3456
<211>   114
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903566 (1.E-55)

<400>   3456
Met Val Ser Ser Lys Tyr Ala Ala Arg Ala Ser Phe Leu Asp Gly Gln 
1               5                   10                  15      

Gly Ile Thr Val Asp Glu Met Ala Trp Ile Ile Arg Gly Ile Val Asn 
            20                  25                  30          

Ala Leu Ile Gly Arg Tyr Ile Lys Leu Gly Thr Tyr Ala Ala Lys Tyr 
        35                  40                  45              

Gly Ile Ser Met Ala Arg Ser Ile Leu Ser Arg Val Ala Ala Thr Ala 
    50                  55                  60                  

Ala Ala Arg Val Gly Leu Leu Thr Lys Ile Ser Gly Trp Ile Leu Arg 
65                  70                  75                  80  

Val Ala Val Asn Val Ala Asp Val Tyr Gly Asn Phe Ala Asn Asn Ile 
                85                  90                  95      

Ala Ala Ala Trp Asp Ala Tyr Asp Lys Ile Pro Asn Asn Gly Arg Ile 
            100                 105                 110         

Asn Phe 
        

<210>   3457
<211>   450
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3457
atgatttttg acgatttgaa aaacatcacc ttttacaaag ggattcatcc taatttagac   60
aaggctatcg actatctcta ccaacatcgt aaggattctt tcgaattagg aaagtatgat   120
attgatggag ataaagtctt tctagttgtt caggaaaatg tcctcaatca agctgaaaat   180
gatcaatttg agtatcataa gaactatgca gatttgcatt tgctggtaga aggacatgaa   240
tattcgagct acggttcacg tatcaaagac gaggcagtag cattcgacga agcgagtgac   300
attggctttg ttcattgtca tgaacactac ccactcttgt tgggttatca caattttgcg   360
attttcttcc caggtgagcc acatcagcca aatggttatg caggcatgga agaaaaggtt   420
cgaaaatatc tctttaaaat tttgattgat                                    450

<210>   3458
<211>   150
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903567 (8.E-86)

<400>   3458
Met Ile Phe Asp Asp Leu Lys Asn Ile Thr Phe Tyr Lys Gly Ile His 
1               5                   10                  15      

Pro Asn Leu Asp Lys Ala Ile Asp Tyr Leu Tyr Gln His Arg Lys Asp 
            20                  25                  30          

Ser Phe Glu Leu Gly Lys Tyr Asp Ile Asp Gly Asp Lys Val Phe Leu 
        35                  40                  45              

Val Val Gln Glu Asn Val Leu Asn Gln Ala Glu Asn Asp Gln Phe Glu 
    50                  55                  60                  

Tyr His Lys Asn Tyr Ala Asp Leu His Leu Leu Val Glu Gly His Glu 
65                  70                  75                  80  

Tyr Ser Ser Tyr Gly Ser Arg Ile Lys Asp Glu Ala Val Ala Phe Asp 
                85                  90                  95      

Glu Ala Ser Asp Ile Gly Phe Val His Cys His Glu His Tyr Pro Leu 
            100                 105                 110         

Leu Leu Gly Tyr His Asn Phe Ala Ile Phe Phe Pro Gly Glu Pro His 
        115                 120                 125             

Gln Pro Asn Gly Tyr Ala Gly Met Glu Glu Lys Val Arg Lys Tyr Leu 
    130                 135                 140                 

Phe Lys Ile Leu Ile Asp 
145                 150 

<210>   3459
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3459
ttgagtatag gaaaatcaat ctatcaagat acagaagtat attttataga tttagagaat   60
atagaggtta taagtgtcta caaaatggag ggtatgcagt tactttatga agttttgtca   120
gacacttata aacttaagaa tggttttagt                                    150

<210>   3460
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3460
Met Ser Ile Gly Lys Ser Ile Tyr Gln Asp Thr Glu Val Tyr Phe Ile 
1               5                   10                  15      

Asp Leu Glu Asn Ile Glu Val Ile Ser Val Tyr Lys Met Glu Gly Met 
            20                  25                  30          

Gln Leu Leu Tyr Glu Val Leu Ser Asp Thr Tyr Lys Leu Lys Asn Gly 
        35                  40                  45              

Phe Ser 
    50  

<210>   3461
<211>   837
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3461

atgcaatcta cagaaaaaaa accattaaca gcctttactg ttatttcaac aatcattttg   60
ctcttgttga ctgtgctgtt catctttcca ttctactgga ttttgacagg ggcattcaaa   120
tcacaacctg atacaattgt tattcctcct cagtggttcc ctaaaatgcc aaccatggaa   180
aacttccaac aactcatggt gcagaaccct gccttgcaat ggatgtggaa ctcagtattt   240
atctcattgg taaccatgtt cttagtttgt gcaacctcat ctctagcagg ttatgtattg   300
gctaaaaaac gtttctatgg tcaacgcatt ctatttgcta tctttatcgc tgctatggcg   360
cttccaaaac aagttgtcct tgtaccattg gtacgtatcg tcaacttcat gggaatccat   420
gatactctct gggcagttat cttgcctttg attggatggc cattcggtgt cttcctcatg   480
aaacagttca gtgaaaatat ccctacagag ttgcttgaat cagctaaaat cgacggttgt   540
ggtgagattc gtaccttctg gagtgtagcc ttcccgattg tgaaaccagg gtttgcagcc   600
cttgcaatct ttaccttcat caatacttgg aatgactact tcatgcaatt ggtaatgttg   660
acttcacgta acaatttgac catctcactt ggggttgcga ccatgcaggc tgaaatggca   720
accaactatg gtttgattat ggcaggagct gcccttgctg ctgttccaat cgtcacagtc   780
ttcctagtct tccaaaaatc cttcacacag ggtattacta tgggagcggt caaagga      837

<210>   3462
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903568 (e-160)

<400>   3462
Met Gln Ser Thr Glu Lys Lys Pro Leu Thr Ala Phe Thr Val Ile Ser 
1               5                   10                  15      

Thr Ile Ile Leu Leu Leu Leu Thr Val Leu Phe Ile Phe Pro Phe Tyr 
            20                  25                  30          

Trp Ile Leu Thr Gly Ala Phe Lys Ser Gln Pro Asp Thr Ile Val Ile 
        35                  40                  45              

Pro Pro Gln Trp Phe Pro Lys Met Pro Thr Met Glu Asn Phe Gln Gln 
    50                  55                  60                  

Leu Met Val Gln Asn Pro Ala Leu Gln Trp Met Trp Asn Ser Val Phe 
65                  70                  75                  80  

Ile Ser Leu Val Thr Met Phe Leu Val Cys Ala Thr Ser Ser Leu Ala 
                85                  90                  95      

Gly Tyr Val Leu Ala Lys Lys Arg Phe Tyr Gly Gln Arg Ile Leu Phe 
            100                 105                 110         

Ala Ile Phe Ile Ala Ala Met Ala Leu Pro Lys Gln Val Val Leu Val 
        115                 120                 125             

Pro Leu Val Arg Ile Val Asn Phe Met Gly Ile His Asp Thr Leu Trp 
    130                 135                 140                 

Ala Val Ile Leu Pro Leu Ile Gly Trp Pro Phe Gly Val Phe Leu Met 
145                 150                 155                 160 

Lys Gln Phe Ser Glu Asn Ile Pro Thr Glu Leu Leu Glu Ser Ala Lys 
                165                 170                 175     

Ile Asp Gly Cys Gly Glu Ile Arg Thr Phe Trp Ser Val Ala Phe Pro 
            180                 185                 190         

Ile Val Lys Pro Gly Phe Ala Ala Leu Ala Ile Phe Thr Phe Ile Asn 
        195                 200                 205             

Thr Trp Asn Asp Tyr Phe Met Gln Leu Val Met Leu Thr Ser Arg Asn 
    210                 215                 220                 

Asn Leu Thr Ile Ser Leu Gly Val Ala Thr Met Gln Ala Glu Met Ala 
225                 230                 235                 240 

Thr Asn Tyr Gly Leu Ile Met Ala Gly Ala Ala Leu Ala Ala Val Pro 
                245                 250                 255     

Ile Val Thr Val Phe Leu Val Phe Gln Lys Ser Phe Thr Gln Gly Ile 
            260                 265                 270         

Thr Met Gly Ala Val Lys Gly 
        275                 

<210>   3463
<211>   894
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3463
gtgccgactg tgaaagtcaa taaaatccgt atgcgggaaa cagtgatttc ctacgctttc   60
ctagcaccag tattattctt ctttgtcatc tttgtgttgg ctccgatggt gatgggcttc   120
attacaagtt tctttaacta ctcaatgact aaatttgagt ttgtaggctt ggataactat   180
atccgtatgt ttaaagatcc tgtctttaca aaatctctga ttaacacagt tattttggtt   240
attggatctg taccagttgt tgttctattc tcactctttg tagcatctca gacctatcat   300
caaaatgtca ttgccagatc cttctaccgt ttcgtcttct tccttcctgt tgtaacgggt   360
agtgttgccg tgacagttgt ttggaaatgg atttatgacc cactatcagg gattctaaac   420
tttgtcctta agtccagcca catcatcagc caaaacattt cttggttggg agataaaaac   480
tgggcattga tggcgattat gattattctc ttgaccactt cagttggtca gcccatcatc   540
ctttatatcg ctgccatggg gaatattgac aattcactgg ttgaagcggc gcgtgttgat   600
ggtgcaactg agtttcaagt tttttggaag attaaatggc caagccttct tccaacaact   660
ctttatattg caatcatcac aacaattaac tcattccagt gtttcgcctt gattcagctt   720
ttgacatctg gtggtccaaa ctactcaaca agtaccttga tgtactacct ttacgaaaaa   780
gccttccaat tgacagaata cggctatgcc aacacaattg gtgtcttctt ggcagtcatg   840
attgctatcg taagctttgt tcaatttaaa gtacttggaa acgacgtaga atac         894

<210>   3464
<211>   298
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903569 (e-169)

<400>   3464
Met Pro Thr Val Lys Val Asn Lys Ile Arg Met Arg Glu Thr Val Ile 
1               5                   10                  15      

Ser Tyr Ala Phe Leu Ala Pro Val Leu Phe Phe Phe Val Ile Phe Val 
            20                  25                  30          

Leu Ala Pro Met Val Met Gly Phe Ile Thr Ser Phe Phe Asn Tyr Ser 
        35                  40                  45              

Met Thr Lys Phe Glu Phe Val Gly Leu Asp Asn Tyr Ile Arg Met Phe 
    50                  55                  60                  

Lys Asp Pro Val Phe Thr Lys Ser Leu Ile Asn Thr Val Ile Leu Val 
65                  70                  75                  80  

Ile Gly Ser Val Pro Val Val Val Leu Phe Ser Leu Phe Val Ala Ser 
                85                  90                  95      

Gln Thr Tyr His Gln Asn Val Ile Ala Arg Ser Phe Tyr Arg Phe Val 
            100                 105                 110         

Phe Phe Leu Pro Val Val Thr Gly Ser Val Ala Val Thr Val Val Trp 
        115                 120                 125             

Lys Trp Ile Tyr Asp Pro Leu Ser Gly Ile Leu Asn Phe Val Leu Lys 
    130                 135                 140                 

Ser Ser His Ile Ile Ser Gln Asn Ile Ser Trp Leu Gly Asp Lys Asn 
145                 150                 155                 160 

Trp Ala Leu Met Ala Ile Met Ile Ile Leu Leu Thr Thr Ser Val Gly 
                165                 170                 175     

Gln Pro Ile Ile Leu Tyr Ile Ala Ala Met Gly Asn Ile Asp Asn Ser 
            180                 185                 190         

Leu Val Glu Ala Ala Arg Val Asp Gly Ala Thr Glu Phe Gln Val Phe 
        195                 200                 205             

Trp Lys Ile Lys Trp Pro Ser Leu Leu Pro Thr Thr Leu Tyr Ile Ala 
    210                 215                 220                 

Ile Ile Thr Thr Ile Asn Ser Phe Gln Cys Phe Ala Leu Ile Gln Leu 
225                 230                 235                 240 

Leu Thr Ser Gly Gly Pro Asn Tyr Ser Thr Ser Thr Leu Met Tyr Tyr 
                245                 250                 255     

Leu Tyr Glu Lys Ala Phe Gln Leu Thr Glu Tyr Gly Tyr Ala Asn Thr 
            260                 265                 270         

Ile Gly Val Phe Leu Ala Val Met Ile Ala Ile Val Ser Phe Val Gln 
        275                 280                 285             

Phe Lys Val Leu Gly Asn Asp Val Glu Tyr 
    290                 295             

<210>   3465
<211>   1326
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3465
atgaaattta gaaaattagc ttgtacagta cttgcgggtg ctgcggttct tggtcttgct   60
gcttgtggca attctggcgg aagtaaagat gctgccaaat caggtggtga cggtgccaaa   120
acagaaatca cttggtgggc attcccagta tttacccaag aaaaaactgg tgacggtgtt   180
ggaacttatg aaaaatcaat catcgaagcg tttgaaaaag caaacccaga tataaaagtg   240
aaattggaaa ccatcgactt caagtcaggt cctgaaaaaa tcacaacagc catcgaagca   300
ggaacagctc cagacgtact ctttgatgca ccaggacgta tcatccaata cggtaaaaac   360
ggtaaattgg ctgagttgaa tgacctcttc acagatgaat ttgttaaaga tgtcaacaat   420
gaaaacatcg tacaagcaag taaagctgga gacaaggctt atatgtatcc gattagttct   480
gccccattct acatggcaat gaacaagaaa atgttagaag atgctggagt agcaaacctt   540
gtaaaagaag gttggacaac tgatgatttt gaaaaagtat tgaaagcact taaagacaag   600
ggttacacac caggttcatt gttcagttct ggtcaagggg gagaccaagg aacacgtgcc   660
tttatctcta acctttatag cggttctgta acagatgaaa aagttagcaa atatacaact   720
gatgatccta aattcgtcaa aggtcttgaa aaagcaacta gctggattaa agacaatttg   780
atcaataatg gttcacaatt tgacggtggg gcagatatcc aaaactttgc caacggtcaa   840
acatcttaca caatcctttg ggcaccagct caaaatggta tccaagctaa acttttagaa   900
gcaagtaagg tagaagtggt agaagtacca ttcccatcag acgaaggtaa gccagctctt   960
gagtaccttg taaacgggtt tgcagtattc aacaataaag acgacaagaa agtcgctgca   1020
tctaagaaat tcatccagtt tatcgcagat gacaaggagt ggggacctaa agacgtagtt   1080
cgtacaggtg ctttcccagt ccgtacttca tttggaaaac tttatgaaga caaacgcatg   1140
gaaacaatca gcggctggac tcaatactac tcaccatact acaacactat tgatggattt   1200
gctgaaatga gaacactttg gttcccaatg ttgcaatctg tatcaaatgg tgacgaaaaa   1260
ccagcagatg ctttgaaagc cttcactgaa aaagcgaacg aaacaatcaa aaaagctatg   1320
aaacaa                                                              1326

<210>   3466
<211>   442
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, sugar-binding protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903570 (0.E+01)

<400>   3466
Met Lys Phe Arg Lys Leu Ala Cys Thr Val Leu Ala Gly Ala Ala Val 
1               5                   10                  15      

Leu Gly Leu Ala Ala Cys Gly Asn Ser Gly Gly Ser Lys Asp Ala Ala 
            20                  25                  30          

Lys Ser Gly Gly Asp Gly Ala Lys Thr Glu Ile Thr Trp Trp Ala Phe 
        35                  40                  45              

Pro Val Phe Thr Gln Glu Lys Thr Gly Asp Gly Val Gly Thr Tyr Glu 
    50                  55                  60                  

Lys Ser Ile Ile Glu Ala Phe Glu Lys Ala Asn Pro Asp Ile Lys Val 
65                  70                  75                  80  

Lys Leu Glu Thr Ile Asp Phe Lys Ser Gly Pro Glu Lys Ile Thr Thr 
                85                  90                  95      

Ala Ile Glu Ala Gly Thr Ala Pro Asp Val Leu Phe Asp Ala Pro Gly 
            100                 105                 110         

Arg Ile Ile Gln Tyr Gly Lys Asn Gly Lys Leu Ala Glu Leu Asn Asp 
        115                 120                 125             

Leu Phe Thr Asp Glu Phe Val Lys Asp Val Asn Asn Glu Asn Ile Val 
    130                 135                 140                 

Gln Ala Ser Lys Ala Gly Asp Lys Ala Tyr Met Tyr Pro Ile Ser Ser 
145                 150                 155                 160 

Ala Pro Phe Tyr Met Ala Met Asn Lys Lys Met Leu Glu Asp Ala Gly 
                165                 170                 175     

Val Ala Asn Leu Val Lys Glu Gly Trp Thr Thr Asp Asp Phe Glu Lys 
            180                 185                 190         

Val Leu Lys Ala Leu Lys Asp Lys Gly Tyr Thr Pro Gly Ser Leu Phe 
        195                 200                 205             

Ser Ser Gly Gln Gly Gly Asp Gln Gly Thr Arg Ala Phe Ile Ser Asn 
    210                 215                 220                 

Leu Tyr Ser Gly Ser Val Thr Asp Glu Lys Val Ser Lys Tyr Thr Thr 
225                 230                 235                 240 

Asp Asp Pro Lys Phe Val Lys Gly Leu Glu Lys Ala Thr Ser Trp Ile 
                245                 250                 255     

Lys Asp Asn Leu Ile Asn Asn Gly Ser Gln Phe Asp Gly Gly Ala Asp 
            260                 265                 270         

Ile Gln Asn Phe Ala Asn Gly Gln Thr Ser Tyr Thr Ile Leu Trp Ala 
        275                 280                 285             

Pro Ala Gln Asn Gly Ile Gln Ala Lys Leu Leu Glu Ala Ser Lys Val 
    290                 295                 300                 

Glu Val Val Glu Val Pro Phe Pro Ser Asp Glu Gly Lys Pro Ala Leu 
305                 310                 315                 320 

Glu Tyr Leu Val Asn Gly Phe Ala Val Phe Asn Asn Lys Asp Asp Lys 
                325                 330                 335     

Lys Val Ala Ala Ser Lys Lys Phe Ile Gln Phe Ile Ala Asp Asp Lys 
            340                 345                 350         

Glu Trp Gly Pro Lys Asp Val Val Arg Thr Gly Ala Phe Pro Val Arg 

        355                 360                 365             

Thr Ser Phe Gly Lys Leu Tyr Glu Asp Lys Arg Met Glu Thr Ile Ser 
    370                 375                 380                 

Gly Trp Thr Gln Tyr Tyr Ser Pro Tyr Tyr Asn Thr Ile Asp Gly Phe 
385                 390                 395                 400 

Ala Glu Met Arg Thr Leu Trp Phe Pro Met Leu Gln Ser Val Ser Asn 
                405                 410                 415     

Gly Asp Glu Lys Pro Ala Asp Ala Leu Lys Ala Phe Thr Glu Lys Ala 
            420                 425                 430         

Asn Glu Thr Ile Lys Lys Ala Met Lys Gln 
        435                 440         

<210>   3467
<211>   1530
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3467
gtgaggggga gttttatgtt taaagtttta caaaaagttg gaaaagcttt tatgttacct   60
atagctatac ttcctgcagc aggtctactt ttggggattg gtggtgcact ttcaaaccca   120
accacgatag caacttatcc aatactagac aatagtattt ttcaatcaat attccaagta   180
atgagctctg caggagaggt tgtattcagt aatttgtcac tacttctctg tgtgggatta   240
tgtattggct tagcgaaacg agataaagga accgctgcgt tagcaggagt aactggttac   300
ttagttatga ctgcaacgat caaagctttg gtaaaacttt ttatggcaga aggatctgca   360
attgatactg gagttattgg agcattagtt gtcggaatag ttgccgtata tttgcacaac   420
cgatataaca atattcaatt accttccgct ttaggattct ttggaggttc acgcttcgtt   480
cctattgtta catcgttctc ttctatcttg attggctttg tcttctttgt tatttggcca   540
cctttccaac aacttcttgt ttctacaggt ggatatattt ctcaggcggg tccaattgga   600
acttttctat atggattttt aatgagactt tctggagcag taggcttaca tcatataatt   660
taccctatgt tttggtatac tgaacttggt ggtgttgaaa ctgttgcagg acaaacagtg   720
gttggagctc aaaaaatatt ttttgctcaa ttagccgatt tggcccattc tggattattt   780
acagaaggaa caaggttttt tgcaggtcgt ttctcaacaa tgatgttcgg tttaccggct   840
gcctgtttag cgatgtacca tagtgttcct aaaaatcgtc gtaaaaaata cgcgggtttg   900
ttttttggag ttgctttaac atcttttatt accggtatta cagaaccaat tgaatttatg   960
tttctattcg tcagtccggt tctatatgtt gttcacgcat tccttgatgg tgttagcttc   1020
tttattgcag acgtcttaaa tatttcaata ggaaacacat tttcaggagg tgtaatcgat   1080
ttcactttat ttggaatttt gcaggggaac gctaagacga attgggttct tcagattcca   1140
tttggactta tttggagtgt tttgtattat attattttta gatggttcat tactcaattc   1200
aacgttctaa cgccagggcg aggagaagaa gtagattcta aagaaatttc tgaatccgca   1260
gattcaactt caaatactgc agattattta aaacaggata gcctacaaat tatcagagcc   1320
ttgggtggat caaataatat agaagatgta gatgcttgtg tgacacgttt acgtgtagct   1380
gtaaaagaag ttaatcaagt tgataaagca cttttaaaac aaattggtgc agttgatgtc   1440
ttagaagtga agggtggcat tcaagcaatc tatggagcaa aagcaatctt atataaaaat   1500
agtattaatg aaattttagg tgtagatgat                                    1530

<210>   3468
<211>   510
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIBC components
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903571 (0.E+01)

<400>   3468
Met Arg Gly Ser Phe Met Phe Lys Val Leu Gln Lys Val Gly Lys Ala 
1               5                   10                  15      

Phe Met Leu Pro Ile Ala Ile Leu Pro Ala Ala Gly Leu Leu Leu Gly 
            20                  25                  30          

Ile Gly Gly Ala Leu Ser Asn Pro Thr Thr Ile Ala Thr Tyr Pro Ile 
        35                  40                  45              

Leu Asp Asn Ser Ile Phe Gln Ser Ile Phe Gln Val Met Ser Ser Ala 
    50                  55                  60                  

Gly Glu Val Val Phe Ser Asn Leu Ser Leu Leu Leu Cys Val Gly Leu 
65                  70                  75                  80  

Cys Ile Gly Leu Ala Lys Arg Asp Lys Gly Thr Ala Ala Leu Ala Gly 
                85                  90                  95      

Val Thr Gly Tyr Leu Val Met Thr Ala Thr Ile Lys Ala Leu Val Lys 
            100                 105                 110         

Leu Phe Met Ala Glu Gly Ser Ala Ile Asp Thr Gly Val Ile Gly Ala 
        115                 120                 125             

Leu Val Val Gly Ile Val Ala Val Tyr Leu His Asn Arg Tyr Asn Asn 
    130                 135                 140                 

Ile Gln Leu Pro Ser Ala Leu Gly Phe Phe Gly Gly Ser Arg Phe Val 
145                 150                 155                 160 

Pro Ile Val Thr Ser Phe Ser Ser Ile Leu Ile Gly Phe Val Phe Phe 
                165                 170                 175     

Val Ile Trp Pro Pro Phe Gln Gln Leu Leu Val Ser Thr Gly Gly Tyr 
            180                 185                 190         

Ile Ser Gln Ala Gly Pro Ile Gly Thr Phe Leu Tyr Gly Phe Leu Met 
        195                 200                 205             

Arg Leu Ser Gly Ala Val Gly Leu His His Ile Ile Tyr Pro Met Phe 
    210                 215                 220                 

Trp Tyr Thr Glu Leu Gly Gly Val Glu Thr Val Ala Gly Gln Thr Val 
225                 230                 235                 240 

Val Gly Ala Gln Lys Ile Phe Phe Ala Gln Leu Ala Asp Leu Ala His 
                245                 250                 255     

Ser Gly Leu Phe Thr Glu Gly Thr Arg Phe Phe Ala Gly Arg Phe Ser 
            260                 265                 270         

Thr Met Met Phe Gly Leu Pro Ala Ala Cys Leu Ala Met Tyr His Ser 
        275                 280                 285             

Val Pro Lys Asn Arg Arg Lys Lys Tyr Ala Gly Leu Phe Phe Gly Val 
    290                 295                 300                 

Ala Leu Thr Ser Phe Ile Thr Gly Ile Thr Glu Pro Ile Glu Phe Met 
305                 310                 315                 320 

Phe Leu Phe Val Ser Pro Val Leu Tyr Val Val His Ala Phe Leu Asp 
                325                 330                 335     

Gly Val Ser Phe Phe Ile Ala Asp Val Leu Asn Ile Ser Ile Gly Asn 
            340                 345                 350         

Thr Phe Ser Gly Gly Val Ile Asp Phe Thr Leu Phe Gly Ile Leu Gln 
        355                 360                 365             

Gly Asn Ala Lys Thr Asn Trp Val Leu Gln Ile Pro Phe Gly Leu Ile 
    370                 375                 380                 

Trp Ser Val Leu Tyr Tyr Ile Ile Phe Arg Trp Phe Ile Thr Gln Phe 
385                 390                 395                 400 

Asn Val Leu Thr Pro Gly Arg Gly Glu Glu Val Asp Ser Lys Glu Ile 
                405                 410                 415     

Ser Glu Ser Ala Asp Ser Thr Ser Asn Thr Ala Asp Tyr Leu Lys Gln 
            420                 425                 430         

Asp Ser Leu Gln Ile Ile Arg Ala Leu Gly Gly Ser Asn Asn Ile Glu 
        435                 440                 445             

Asp Val Asp Ala Cys Val Thr Arg Leu Arg Val Ala Val Lys Glu Val 
    450                 455                 460                 

Asn Gln Val Asp Lys Ala Leu Leu Lys Gln Ile Gly Ala Val Asp Val 
465                 470                 475                 480 

Leu Glu Val Lys Gly Gly Ile Gln Ala Ile Tyr Gly Ala Lys Ala Ile 

                485                 490                 495     

Leu Tyr Lys Asn Ser Ile Asn Glu Ile Leu Gly Val Asp Asp 
            500                 505                 510 

<210>   3469
<211>   696
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3469
atgccacaga ttagcaaaga agccttgatt gagcaaatca aagatggaat catcgtttct   60
tgtcaggctc ttcctcatga accgctttat acagaagcgg gaggggtgat tcccttgctg   120
gtcaaagcgg ctgagcaagg tggagcagtc ggtatccgag caaacagtgt tcgcgatatc   180
aaggaaatta aggaagtcac taaacttcca atcattggga ttatcaaacg tgattatcca   240
cctcaggaac ccttcatcac ggctactatg aaagaagttg atgaattggc agaactggac   300
atcgaggtga ttgctctgga ttgtaccaag cgtgaacgct acgatggttt ggaaattcaa   360
gagttcattc gtcaggttaa ggagaaatat cctaatcagc ttttgatggc tgatactagt   420
atcttcgaag aagggctagc agctgtagaa gcaggaattg actttgtcgg aacaacctta   480
tcaggctaca catcctacag tccaaaagta gacggtccag attttgaatt gattaagaaa   540
ctctgtgatg ctggtgtaga tgtcattgca gaaggaaaaa ttcatacacc agaacaagcc   600
aaacaaatcc ttgaatatgg agtgcgaggc atcgttgttg gtggcgccat tactagacca   660
aaagagatta cagaacgctt cgttgctagt cttaaa                             696

<210>   3470
<211>   232
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (N-acetylmannosamine-6-P)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903572 (e-129)

<400>   3470
Met Pro Gln Ile Ser Lys Glu Ala Leu Ile Glu Gln Ile Lys Asp Gly 
1               5                   10                  15      

Ile Ile Val Ser Cys Gln Ala Leu Pro His Glu Pro Leu Tyr Thr Glu 
            20                  25                  30          

Ala Gly Gly Val Ile Pro Leu Leu Val Lys Ala Ala Glu Gln Gly Gly 
        35                  40                  45              

Ala Val Gly Ile Arg Ala Asn Ser Val Arg Asp Ile Lys Glu Ile Lys 
    50                  55                  60                  

Glu Val Thr Lys Leu Pro Ile Ile Gly Ile Ile Lys Arg Asp Tyr Pro 
65                  70                  75                  80  

Pro Gln Glu Pro Phe Ile Thr Ala Thr Met Lys Glu Val Asp Glu Leu 
                85                  90                  95      

Ala Glu Leu Asp Ile Glu Val Ile Ala Leu Asp Cys Thr Lys Arg Glu 
            100                 105                 110         

Arg Tyr Asp Gly Leu Glu Ile Gln Glu Phe Ile Arg Gln Val Lys Glu 
        115                 120                 125             

Lys Tyr Pro Asn Gln Leu Leu Met Ala Asp Thr Ser Ile Phe Glu Glu 
    130                 135                 140                 

Gly Leu Ala Ala Val Glu Ala Gly Ile Asp Phe Val Gly Thr Thr Leu 
145                 150                 155                 160 

Ser Gly Tyr Thr Ser Tyr Ser Pro Lys Val Asp Gly Pro Asp Phe Glu 
                165                 170                 175     

Leu Ile Lys Lys Leu Cys Asp Ala Gly Val Asp Val Ile Ala Glu Gly 
            180                 185                 190         

Lys Ile His Thr Pro Glu Gln Ala Lys Gln Ile Leu Glu Tyr Gly Val 
        195                 200                 205             

Arg Gly Ile Val Val Gly Gly Ala Ile Thr Arg Pro Lys Glu Ile Thr 
    210                 215                 220                 

Glu Arg Phe Val Ala Ser Leu Lys 
225                 230         

<210>   3471
<211>   1101
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3471
atggttaaat acggtgttgt tggaacaggg tattttggag ctgaattggc tcgctacatg   60
caaaagaatg atggagcaga gattactctt ctctatgatc cagataatgc agaggcgatt   120
gcagaagaat tgggagcaaa agtagcaagt tccttagatg agttggtttc tagcgatgaa   180
gtagattgtg ttatcgtcgc aactccaaat aatcttcata aggaaccggt tattaaggct   240
gcacagcatg gtaaaaatgt tttctgtgaa aaaccaattg cgctttctta tcaagattgt   300
cgcgagatgg tagatgcgtg taaagaaaac aatgtaacct ttatggcagg acatattatg   360
aatttcttta atggtgttca tcatgcaaaa gaactcatta atcaaggagt tatcggagac   420
gttctatatt gtcatacagc tcgtaatggt tgggaagaac aacaaccgtc agtatcatgg   480
aaaaaaattc gtgaaaaatc aggtggtcac ttgtatcacc acatccatga attggattgc   540
gttcaattcc ttatgggggg catgcctgaa actgtaacca tgacaggtgg aaatgtggcc   600
catgaaggtg aacatttcgg tgatgaagat gatatgattt ttgtcaatat ggaattttct   660
aataagcgtt ttgccttgtt agaatggggt tcagcttatc gttggggtga acattatgtc   720
ttaatccaag gaagcaaagg tgccatccgc ttagacttat tcaactgtaa aggaactctt   780
aagctagatg ggcaagaaag ctatttcttg attcacgaat cgcaagaaga agatgatgat   840
cggactcgta tctatcatag tacagagatg gatggagcaa ttgcttatgg taaaccaggt   900
aaacgtactc cattatggct atcatctgtc attgataaag aaatgcgcta tctgcatgag   960
attatggaag gagctccagt atcagaagaa tttgcaaaac ttttgacagg tgaagctgcc   1020
ctagaagcaa ttgctactgc agatgcttgt acccagtcta tgtttgaaga tcgcaaagta   1080
aaattgtcag aaattgtaaa a                                             1101

<210>   3472
<211>   367
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, Gfo/Idh/MocA family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903573 (0.E+01)

<400>   3472

Met Val Lys Tyr Gly Val Val Gly Thr Gly Tyr Phe Gly Ala Glu Leu 
1               5                   10                  15      

Ala Arg Tyr Met Gln Lys Asn Asp Gly Ala Glu Ile Thr Leu Leu Tyr 
            20                  25                  30          

Asp Pro Asp Asn Ala Glu Ala Ile Ala Glu Glu Leu Gly Ala Lys Val 
        35                  40                  45              

Ala Ser Ser Leu Asp Glu Leu Val Ser Ser Asp Glu Val Asp Cys Val 
    50                  55                  60                  

Ile Val Ala Thr Pro Asn Asn Leu His Lys Glu Pro Val Ile Lys Ala 
65                  70                  75                  80  

Ala Gln His Gly Lys Asn Val Phe Cys Glu Lys Pro Ile Ala Leu Ser 
                85                  90                  95      

Tyr Gln Asp Cys Arg Glu Met Val Asp Ala Cys Lys Glu Asn Asn Val 
            100                 105                 110         

Thr Phe Met Ala Gly His Ile Met Asn Phe Phe Asn Gly Val His His 
        115                 120                 125             

Ala Lys Glu Leu Ile Asn Gln Gly Val Ile Gly Asp Val Leu Tyr Cys 
    130                 135                 140                 

His Thr Ala Arg Asn Gly Trp Glu Glu Gln Gln Pro Ser Val Ser Trp 
145                 150                 155                 160 

Lys Lys Ile Arg Glu Lys Ser Gly Gly His Leu Tyr His His Ile His 
                165                 170                 175     

Glu Leu Asp Cys Val Gln Phe Leu Met Gly Gly Met Pro Glu Thr Val 
            180                 185                 190         

Thr Met Thr Gly Gly Asn Val Ala His Glu Gly Glu His Phe Gly Asp 
        195                 200                 205             

Glu Asp Asp Met Ile Phe Val Asn Met Glu Phe Ser Asn Lys Arg Phe 
    210                 215                 220                 

Ala Leu Leu Glu Trp Gly Ser Ala Tyr Arg Trp Gly Glu His Tyr Val 
225                 230                 235                 240 

Leu Ile Gln Gly Ser Lys Gly Ala Ile Arg Leu Asp Leu Phe Asn Cys 
                245                 250                 255     

Lys Gly Thr Leu Lys Leu Asp Gly Gln Glu Ser Tyr Phe Leu Ile His 
            260                 265                 270         

Glu Ser Gln Glu Glu Asp Asp Asp Arg Thr Arg Ile Tyr His Ser Thr 
        275                 280                 285             

Glu Met Asp Gly Ala Ile Ala Tyr Gly Lys Pro Gly Lys Arg Thr Pro 
    290                 295                 300                 

Leu Trp Leu Ser Ser Val Ile Asp Lys Glu Met Arg Tyr Leu His Glu 
305                 310                 315                 320 

Ile Met Glu Gly Ala Pro Val Ser Glu Glu Phe Ala Lys Leu Leu Thr 
                325                 330                 335     

Gly Glu Ala Ala Leu Glu Ala Ile Ala Thr Ala Asp Ala Cys Thr Gln 
            340                 345                 350         

Ser Met Phe Glu Asp Arg Lys Val Lys Leu Ser Glu Ile Val Lys 
        355                 360                 365         


<210>   3473
<211>   2091
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3473
atgaataaaa gaggtcttta ttcaaaacta ggaatttccg ttgtaggcat tagtctttta   60
atgggagtcc ccactttgat tcatgcgaat gaattaaact atggtcaact gtccatatct   120
cctatttttc aaggaggttc atatcaactg aacaataaga gtatagatat cagctctttg   180
ttattagata aattgtctgg agagagtcag acagtagtaa tgaaatttaa agcagataaa   240
ccaaactctc ttcaagcttt gtttggccta tctaatagta aagcaggctt taaaaataat   300
tacttttcaa ttttcatgag agattctggt gagataggtg tagaaataag agacgcccaa   360
aagggaataa attatttatt ttccagacca gcttcattat ggggaaaaca taaaggacag   420
gcagttgaaa atacactagt atttgtatct gattctaaag ataaaacata cacaatgtat   480
gttaatggaa tagaagtgtt ctctgaaaca gttgatacat ttttgccaat ttcaaatata   540
aatggtatag ataaggcaac actaggagct gttaatcgtg aaggtaagga acattacctc   600
gcaaaaggaa gtattgatga aatcagtcta tttaacaaag caattagtga tcaggaagtt   660
tcaactattc ccttgtcaaa tccatttcag ttaattttcc aatcaggaga ttctactcaa   720
gctaactatt ttagaatacc gacactatat acattaagta gtggaagagt tctatcaagt   780
attgatgcac gttatggtgg gactcatgat tctaaaagta agattaatat tgccacttct   840
tatagtgatg ataatgggaa aacgtggagt gagccaattt ttgctatgaa gtttaatgac   900
tatgaggagc agttagttta ctggccacga gataataaat taaagaatag tcaaattagt   960
ggaagtgctt cattcataga ttcatccatt gttgaagata aaaaatctgg gaaaacgata   1020
ttactagctg atgttatgcc tgcgggtatt ggaaataata atgcaaataa agccgactca   1080
ggttttaaag aaataaatgg tcattattat ttaaaactaa agaagaatgg agataacgat   1140
ttccgttata cagttagaga aaatggtgtc gtttataatg aaacaactaa taaacctaca   1200
aattatacta taaatgataa gtatgaagtt ttggagggag gaaagtcttt aacagtcgaa   1260
caatattcgg ttgattttga tagtggctct ttaagagaaa ggcataatgg aaaacaggtt   1320
cctatgaatg ttttctacaa agattcgtta tttaaagtga ctcctactaa ttatatagca   1380
atgacaacta gtcagaatag aggagagagt tgggaacaat ttaagttgtt gcctccgttc   1440
ttaggagaaa aacataatgg aacttactta tgtcccggac aaggtttagc attaaaatca   1500
agtaacagat tgatttttgc aacatatact agtggagaac taacctatct catttctgat   1560
gatagtggtc aaacatggaa gaaatcctca gcttcaattc cgtttaaaaa tgcaacagca   1620
gaagcacaaa tggttgaact gagagatggt gtgattagaa cattctttag aaccactaca   1680
ggtaagatag cttatatgac tagtagagat tctggagaaa catggtcgaa agtttcgtat   1740
attgatggaa tccaacaaac ttcatatggc acacaagtat ctgcaattaa atactctcaa   1800
ttaattgatg gaaaagaagc agtcattttg agtacaccaa attctagaag tggccgcaag   1860
ggaggccaat tagttgtcgg tttagtcaat aaagaagatg atagtattga ttggaaatac   1920
cactatgata ttgatttgcc ttcgtatggt tatgcctatt ctgcgattac agaattgcca   1980
aatcatcaca taggtgtact gtttgaaaaa tatgattcgt ggtcgagaaa tgaattgcat   2040
ttaagcaatg tagttcagta tatagatttg gaaattaatg atttaacaaa a            2091

<210>   3474
<211>   697
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   neuraminidase B (nanB)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903574 (0.E+01)

<400>   3474
Met Asn Lys Arg Gly Leu Tyr Ser Lys Leu Gly Ile Ser Val Val Gly 
1               5                   10                  15      

Ile Ser Leu Leu Met Gly Val Pro Thr Leu Ile His Ala Asn Glu Leu 
            20                  25                  30          

Asn Tyr Gly Gln Leu Ser Ile Ser Pro Ile Phe Gln Gly Gly Ser Tyr 
        35                  40                  45              

Gln Leu Asn Asn Lys Ser Ile Asp Ile Ser Ser Leu Leu Leu Asp Lys 
    50                  55                  60                  

Leu Ser Gly Glu Ser Gln Thr Val Val Met Lys Phe Lys Ala Asp Lys 
65                  70                  75                  80  

Pro Asn Ser Leu Gln Ala Leu Phe Gly Leu Ser Asn Ser Lys Ala Gly 
                85                  90                  95      

Phe Lys Asn Asn Tyr Phe Ser Ile Phe Met Arg Asp Ser Gly Glu Ile 
            100                 105                 110         

Gly Val Glu Ile Arg Asp Ala Gln Lys Gly Ile Asn Tyr Leu Phe Ser 
        115                 120                 125             

Arg Pro Ala Ser Leu Trp Gly Lys His Lys Gly Gln Ala Val Glu Asn 
    130                 135                 140                 

Thr Leu Val Phe Val Ser Asp Ser Lys Asp Lys Thr Tyr Thr Met Tyr 
145                 150                 155                 160 

Val Asn Gly Ile Glu Val Phe Ser Glu Thr Val Asp Thr Phe Leu Pro 
                165                 170                 175     

Ile Ser Asn Ile Asn Gly Ile Asp Lys Ala Thr Leu Gly Ala Val Asn 
            180                 185                 190         

Arg Glu Gly Lys Glu His Tyr Leu Ala Lys Gly Ser Ile Asp Glu Ile 
        195                 200                 205             

Ser Leu Phe Asn Lys Ala Ile Ser Asp Gln Glu Val Ser Thr Ile Pro 
    210                 215                 220                 

Leu Ser Asn Pro Phe Gln Leu Ile Phe Gln Ser Gly Asp Ser Thr Gln 
225                 230                 235                 240 

Ala Asn Tyr Phe Arg Ile Pro Thr Leu Tyr Thr Leu Ser Ser Gly Arg 
                245                 250                 255     

Val Leu Ser Ser Ile Asp Ala Arg Tyr Gly Gly Thr His Asp Ser Lys 
            260                 265                 270         

Ser Lys Ile Asn Ile Ala Thr Ser Tyr Ser Asp Asp Asn Gly Lys Thr 
        275                 280                 285             

Trp Ser Glu Pro Ile Phe Ala Met Lys Phe Asn Asp Tyr Glu Glu Gln 
    290                 295                 300                 

Leu Val Tyr Trp Pro Arg Asp Asn Lys Leu Lys Asn Ser Gln Ile Ser 
305                 310                 315                 320 

Gly Ser Ala Ser Phe Ile Asp Ser Ser Ile Val Glu Asp Lys Lys Ser 
                325                 330                 335     

Gly Lys Thr Ile Leu Leu Ala Asp Val Met Pro Ala Gly Ile Gly Asn 
            340                 345                 350         

Asn Asn Ala Asn Lys Ala Asp Ser Gly Phe Lys Glu Ile Asn Gly His 
        355                 360                 365             

Tyr Tyr Leu Lys Leu Lys Lys Asn Gly Asp Asn Asp Phe Arg Tyr Thr 
    370                 375                 380                 

Val Arg Glu Asn Gly Val Val Tyr Asn Glu Thr Thr Asn Lys Pro Thr 
385                 390                 395                 400 

Asn Tyr Thr Ile Asn Asp Lys Tyr Glu Val Leu Glu Gly Gly Lys Ser 
                405                 410                 415     

Leu Thr Val Glu Gln Tyr Ser Val Asp Phe Asp Ser Gly Ser Leu Arg 
            420                 425                 430         

Glu Arg His Asn Gly Lys Gln Val Pro Met Asn Val Phe Tyr Lys Asp 
        435                 440                 445             

Ser Leu Phe Lys Val Thr Pro Thr Asn Tyr Ile Ala Met Thr Thr Ser 
    450                 455                 460                 

Gln Asn Arg Gly Glu Ser Trp Glu Gln Phe Lys Leu Leu Pro Pro Phe 
465                 470                 475                 480 

Leu Gly Glu Lys His Asn Gly Thr Tyr Leu Cys Pro Gly Gln Gly Leu 
                485                 490                 495     

Ala Leu Lys Ser Ser Asn Arg Leu Ile Phe Ala Thr Tyr Thr Ser Gly 
            500                 505                 510         

Glu Leu Thr Tyr Leu Ile Ser Asp Asp Ser Gly Gln Thr Trp Lys Lys 
        515                 520                 525             

Ser Ser Ala Ser Ile Pro Phe Lys Asn Ala Thr Ala Glu Ala Gln Met 
    530                 535                 540                 

Val Glu Leu Arg Asp Gly Val Ile Arg Thr Phe Phe Arg Thr Thr Thr 
545                 550                 555                 560 

Gly Lys Ile Ala Tyr Met Thr Ser Arg Asp Ser Gly Glu Thr Trp Ser 
                565                 570                 575     

Lys Val Ser Tyr Ile Asp Gly Ile Gln Gln Thr Ser Tyr Gly Thr Gln 
            580                 585                 590         

Val Ser Ala Ile Lys Tyr Ser Gln Leu Ile Asp Gly Lys Glu Ala Val 
        595                 600                 605             

Ile Leu Ser Thr Pro Asn Ser Arg Ser Gly Arg Lys Gly Gly Gln Leu 
    610                 615                 620                 

Val Val Gly Leu Val Asn Lys Glu Asp Asp Ser Ile Asp Trp Lys Tyr 
625                 630                 635                 640 

His Tyr Asp Ile Asp Leu Pro Ser Tyr Gly Tyr Ala Tyr Ser Ala Ile 
                645                 650                 655     

Thr Glu Leu Pro Asn His His Ile Gly Val Leu Phe Glu Lys Tyr Asp 
            660                 665                 670         

Ser Trp Ser Arg Asn Glu Leu His Leu Ser Asn Val Val Gln Tyr Ile 
        675                 680                 685             

Asp Leu Glu Ile Asn Asp Leu Thr Lys 
    690                 695         

<210>   3475
<211>   831
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3475
atgaagaaga aatccagtat ttatttagat attctctcac atgtactttt agttggtgcg   60
accatcgttg cagttttccc attggtatgg attatcatat cttctgtcaa agggaaaggg   120
gaattaactc agtatccaac acgattttgg cctgaacagt ttacattaga ttatttcact   180
catgttatca acgatttgca cttcattgat aacattcgaa acagtttaat cattgccttg   240
gctacaaccc ttattgcgat tattatttct gctatggcag cctatggtat tgttcgattc   300
tttcctaaat tgggagcaat catgtcgaga ctactcgtca ttacctacat tttcccacca   360
attttgttag caattcccta ttcaattgcc attgctaaag ttgggttaac aaatagttta   420
tttggcttga tgatggttta tctatctttt agtgttccat atgcagtttg gctcttagtt   480
ggatttttcc aaacagttcc aattggaatt gaagaagcgg ctagaattga tggtgcaaat   540
aaatttgtta cgttttataa agttgtgcta ccgattgtag caccaggtat tgtagcaaca   600
gctatttata catttatcaa tgcttggaat gaattcctgt atgccttgat tttgattaac   660
aatacaggaa agatgacagt agcagtagcc cttcgttcac ttaatggttc agaaatacta   720
gactggggag atatgatggc agcgtctgtt attgtagttc ttccatcaat tattttcttc   780
tctatcatcc aaaataagat tgcaagtgga ttatcagaag gatctgtgaa g            831

<210>   3476
<211>   277
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903575 (e-153)

<400>   3476
Met Lys Lys Lys Ser Ser Ile Tyr Leu Asp Ile Leu Ser His Val Leu 
1               5                   10                  15      

Leu Val Gly Ala Thr Ile Val Ala Val Phe Pro Leu Val Trp Ile Ile 
            20                  25                  30          

Ile Ser Ser Val Lys Gly Lys Gly Glu Leu Thr Gln Tyr Pro Thr Arg 
        35                  40                  45              

Phe Trp Pro Glu Gln Phe Thr Leu Asp Tyr Phe Thr His Val Ile Asn 
    50                  55                  60                  

Asp Leu His Phe Ile Asp Asn Ile Arg Asn Ser Leu Ile Ile Ala Leu 

65                  70                  75                  80  

Ala Thr Thr Leu Ile Ala Ile Ile Ile Ser Ala Met Ala Ala Tyr Gly 
                85                  90                  95      

Ile Val Arg Phe Phe Pro Lys Leu Gly Ala Ile Met Ser Arg Leu Leu 
            100                 105                 110         

Val Ile Thr Tyr Ile Phe Pro Pro Ile Leu Leu Ala Ile Pro Tyr Ser 
        115                 120                 125             

Ile Ala Ile Ala Lys Val Gly Leu Thr Asn Ser Leu Phe Gly Leu Met 
    130                 135                 140                 

Met Val Tyr Leu Ser Phe Ser Val Pro Tyr Ala Val Trp Leu Leu Val 
145                 150                 155                 160 

Gly Phe Phe Gln Thr Val Pro Ile Gly Ile Glu Glu Ala Ala Arg Ile 
                165                 170                 175     

Asp Gly Ala Asn Lys Phe Val Thr Phe Tyr Lys Val Val Leu Pro Ile 
            180                 185                 190         

Val Ala Pro Gly Ile Val Ala Thr Ala Ile Tyr Thr Phe Ile Asn Ala 
        195                 200                 205             

Trp Asn Glu Phe Leu Tyr Ala Leu Ile Leu Ile Asn Asn Thr Gly Lys 
    210                 215                 220                 

Met Thr Val Ala Val Ala Leu Arg Ser Leu Asn Gly Ser Glu Ile Leu 
225                 230                 235                 240 

Asp Trp Gly Asp Met Met Ala Ala Ser Val Ile Val Val Leu Pro Ser 
                245                 250                 255     

Ile Ile Phe Phe Ser Ile Ile Gln Asn Lys Ile Ala Ser Gly Leu Ser 
            260                 265                 270         

Glu Gly Ser Val Lys 
        275         

<210>   3477
<211>   882
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3477
atggttaaag aacgtaattt aactcgctgg atatttgttt tgccagctat gattatcgta   60
ggattactct ttgtttatcc gtttttctcg agtatttttt atagctttac caataagcat   120
ttgattatgc ctaattataa atttgttggt ttggctaact ataaagctgt gctatcagat   180
cccaacttct ttaatgcgtt ctttaattca attaagtgga ccgttttctc attagttggt   240
caagttttag tagggtttgt attggcttta gctcttcaca gagtacgcca cttcaagaaa   300
ttatatagga cattattgat tgttccttgg gcatttccta ccatcgttat tgccttctct   360
tggcagtgga ttctaaacgg ggtttatggc tacttaccta atctaatcgt aaaattaggt   420
ttaatggaac atacacctgc atttttgaca gatagtacat gggcattcct atgtttggtg   480
tttatcaaca tttggtttgg agcaccaatg attatggtta atgtgctttc agctttgcaa   540
acagtaccag aagaacaatt tgaggctgct aagatagatg gtgcttcaag ttggcaggtg   600
ttcaagttta tcgtctttcc acatattaaa gtggttgtag gacttctagt tgttttgaga   660
actgtatgga tctttaataa ctttgacatt atctacctca ttactggtgg tggaccagcc   720
aatgctacaa cgacgcttcc aatttttgct tacaacctgg gctggggaac taaattgttg   780
ggtcgtgctt cagcagttac agtactgctc tttatcttct tggtggcgat ttgctttatc   840
tactttgcta tcatcagtaa gtgggaaaag gagggtagaa aa                      882

<210>   3478
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903576 (e-173)

<400>   3478
Met Val Lys Glu Arg Asn Leu Thr Arg Trp Ile Phe Val Leu Pro Ala 
1               5                   10                  15      

Met Ile Ile Val Gly Leu Leu Phe Val Tyr Pro Phe Phe Ser Ser Ile 
            20                  25                  30          

Phe Tyr Ser Phe Thr Asn Lys His Leu Ile Met Pro Asn Tyr Lys Phe 
        35                  40                  45              

Val Gly Leu Ala Asn Tyr Lys Ala Val Leu Ser Asp Pro Asn Phe Phe 
    50                  55                  60                  


Asn Ala Phe Phe Asn Ser Ile Lys Trp Thr Val Phe Ser Leu Val Gly 
65                  70                  75                  80  

Gln Val Leu Val Gly Phe Val Leu Ala Leu Ala Leu His Arg Val Arg 
                85                  90                  95      

His Phe Lys Lys Leu Tyr Arg Thr Leu Leu Ile Val Pro Trp Ala Phe 
            100                 105                 110         

Pro Thr Ile Val Ile Ala Phe Ser Trp Gln Trp Ile Leu Asn Gly Val 
        115                 120                 125             

Tyr Gly Tyr Leu Pro Asn Leu Ile Val Lys Leu Gly Leu Met Glu His 
    130                 135                 140                 

Thr Pro Ala Phe Leu Thr Asp Ser Thr Trp Ala Phe Leu Cys Leu Val 
145                 150                 155                 160 

Phe Ile Asn Ile Trp Phe Gly Ala Pro Met Ile Met Val Asn Val Leu 
                165                 170                 175     

Ser Ala Leu Gln Thr Val Pro Glu Glu Gln Phe Glu Ala Ala Lys Ile 
            180                 185                 190         

Asp Gly Ala Ser Ser Trp Gln Val Phe Lys Phe Ile Val Phe Pro His 
        195                 200                 205             

Ile Lys Val Val Val Gly Leu Leu Val Val Leu Arg Thr Val Trp Ile 
    210                 215                 220                 

Phe Asn Asn Phe Asp Ile Ile Tyr Leu Ile Thr Gly Gly Gly Pro Ala 
225                 230                 235                 240 

Asn Ala Thr Thr Thr Leu Pro Ile Phe Ala Tyr Asn Leu Gly Trp Gly 
                245                 250                 255     

Thr Lys Leu Leu Gly Arg Ala Ser Ala Val Thr Val Leu Leu Phe Ile 
            260                 265                 270         

Phe Leu Val Ala Ile Cys Phe Ile Tyr Phe Ala Ile Ile Ser Lys Trp 
        275                 280                 285             

Glu Lys Glu Gly Arg Lys 
    290                 

<210>   3479
<211>   1335
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3479
atgaaaaaaa tgagaaagtt tttatgtcta gctggaattg cgctagcggc tgttgccttg   60
gtagcttgtt caggaaaaaa agaagctaca actagtactg aaccaccaac agaattatct   120
ggtgagatta caatgtggca ctcctttact caaggacccc gtttagaaag tattcaaaaa   180
tcagcagatg ctttcatgca aaagcatcca aaaacgaaaa tcaagattga aacattttct   240
tggaatgact tctatactaa atggactaca ggtttagcaa atggaaatgt gccagatatc   300
agtacagctc ttcctaacca agtaatggaa atggtcaact cagatgcttt ggttccgcta   360
aatgattcta tcaagcgtat tggacaagat aaatttaacg aaactgcctt aaatgaagca   420
aaaatcggag atgattacta ctctgttcct ctttattcac atgcacaagt catgtgggtt   480
agaacagatt tgttaaaaga acataatatt gaggttccta aaacttggga tcaactctat   540
gaagcttcta aaaaattgaa agaagctgga gtttatggct tgtctgttcc gtttggaaca   600
aatgacttaa tggcaacacg tttcttgaac ttctacgtac gtagtggtgg aggaagcctc   660
ttaacaaaag atcttaaagc agacttgaca agccaacttg ctcaagatgg tattaaatac   720
tgggttaaat tgtataaaga aatctcacct caagattctt tgaactttaa tgtccttcaa   780
caagctacct tgttctatca aggaaaaaca gcatttgact ttaactctgg cttccatatc   840
ggaggaatta atgccaacag tcctcaattg attgattcga ttgatgctta tcctattcca   900
aaaatcaaag agtctgataa agaccaagga attgaaacct caaacattcc aatggttgtt   960
tggaaaaatt caaaacatcc agaagttgct aaagcattct tagaagcact ttataatgaa   1020
gaagactacg ttaaattcct tgattcaact ccagtaggta tgttgccaac tattaagggg   1080
attagcgatt ctgcagccta taaagaaaat gaaactcgta agaaatttaa acatgctgaa   1140
gaagtaatta ctgaagctgt taaaaaaggt actgctattg gttatgaaaa tgggccaagt   1200
gtacaagctg gtatgttgac taaccaacac attattgaac aaatgttcca agatatcatt   1260
acaaatggaa cagatcctat gaaagcagca aaagaagcag aaaaacaatt aaatgattta   1320
tttgaggctg ttcag                                                    1335

<210>   3480
<211>   445
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, substrate-binding protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903577 (0.E+01)

<400>   3480
Met Lys Lys Met Arg Lys Phe Leu Cys Leu Ala Gly Ile Ala Leu Ala 
1               5                   10                  15      

Ala Val Ala Leu Val Ala Cys Ser Gly Lys Lys Glu Ala Thr Thr Ser 
            20                  25                  30          

Thr Glu Pro Pro Thr Glu Leu Ser Gly Glu Ile Thr Met Trp His Ser 
        35                  40                  45              

Phe Thr Gln Gly Pro Arg Leu Glu Ser Ile Gln Lys Ser Ala Asp Ala 
    50                  55                  60                  

Phe Met Gln Lys His Pro Lys Thr Lys Ile Lys Ile Glu Thr Phe Ser 
65                  70                  75                  80  

Trp Asn Asp Phe Tyr Thr Lys Trp Thr Thr Gly Leu Ala Asn Gly Asn 
                85                  90                  95      

Val Pro Asp Ile Ser Thr Ala Leu Pro Asn Gln Val Met Glu Met Val 
            100                 105                 110         

Asn Ser Asp Ala Leu Val Pro Leu Asn Asp Ser Ile Lys Arg Ile Gly 
        115                 120                 125             

Gln Asp Lys Phe Asn Glu Thr Ala Leu Asn Glu Ala Lys Ile Gly Asp 
    130                 135                 140                 

Asp Tyr Tyr Ser Val Pro Leu Tyr Ser His Ala Gln Val Met Trp Val 
145                 150                 155                 160 

Arg Thr Asp Leu Leu Lys Glu His Asn Ile Glu Val Pro Lys Thr Trp 
                165                 170                 175     

Asp Gln Leu Tyr Glu Ala Ser Lys Lys Leu Lys Glu Ala Gly Val Tyr 
            180                 185                 190         

Gly Leu Ser Val Pro Phe Gly Thr Asn Asp Leu Met Ala Thr Arg Phe 
        195                 200                 205             

Leu Asn Phe Tyr Val Arg Ser Gly Gly Gly Ser Leu Leu Thr Lys Asp 
    210                 215                 220                 

Leu Lys Ala Asp Leu Thr Ser Gln Leu Ala Gln Asp Gly Ile Lys Tyr 
225                 230                 235                 240 

Trp Val Lys Leu Tyr Lys Glu Ile Ser Pro Gln Asp Ser Leu Asn Phe 
                245                 250                 255     

Asn Val Leu Gln Gln Ala Thr Leu Phe Tyr Gln Gly Lys Thr Ala Phe 
            260                 265                 270         

Asp Phe Asn Ser Gly Phe His Ile Gly Gly Ile Asn Ala Asn Ser Pro 
        275                 280                 285             

Gln Leu Ile Asp Ser Ile Asp Ala Tyr Pro Ile Pro Lys Ile Lys Glu 
    290                 295                 300                 

Ser Asp Lys Asp Gln Gly Ile Glu Thr Ser Asn Ile Pro Met Val Val 
305                 310                 315                 320 

Trp Lys Asn Ser Lys His Pro Glu Val Ala Lys Ala Phe Leu Glu Ala 
                325                 330                 335     

Leu Tyr Asn Glu Glu Asp Tyr Val Lys Phe Leu Asp Ser Thr Pro Val 
            340                 345                 350         

Gly Met Leu Pro Thr Ile Lys Gly Ile Ser Asp Ser Ala Ala Tyr Lys 
        355                 360                 365             

Glu Asn Glu Thr Arg Lys Lys Phe Lys His Ala Glu Glu Val Ile Thr 
    370                 375                 380                 

Glu Ala Val Lys Lys Gly Thr Ala Ile Gly Tyr Glu Asn Gly Pro Ser 
385                 390                 395                 400 

Val Gln Ala Gly Met Leu Thr Asn Gln His Ile Ile Glu Gln Met Phe 
                405                 410                 415     

Gln Asp Ile Ile Thr Asn Gly Thr Asp Pro Met Lys Ala Ala Lys Glu 
            420                 425                 430         

Ala Glu Lys Gln Leu Asn Asp Leu Phe Glu Ala Val Gln 
        435                 440                 445 

<210>   3481
<211>   450
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3481
atgattatta caaaaattag ccgtttagga acttatgtgg gagtaaatcc acattttgca   60
acattaatag attttctaga aaaaacagga ctagaaaatt taacagaagg ttcgattgct   120
atcgatggta atcgattgtt tgggaattgc tttacttatc tagcagatgg tcaagcaggg   180
gctttctttg aaacccacca aaaatatttg gatattcatt tagttttgga aaacgaagaa   240
gccatggctg ttacatcgcc ggaaaatgta agcgttaccc aagaatatga tgaagagaaa   300
gatattgaat tatacacagg gaaagtggaa cagttggttc atttgagagc tggcgaatgc   360
ctcatcactt ttccagaaga tttacatcaa cccaaggttc gtataaatga tgaacctgtg   420
aaaaaagttg tctttaaagt tgcgatttct                                    450

<210>   3482
<211>   150
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903578 (5.E-84)

<400>   3482
Met Ile Ile Thr Lys Ile Ser Arg Leu Gly Thr Tyr Val Gly Val Asn 
1               5                   10                  15      

Pro His Phe Ala Thr Leu Ile Asp Phe Leu Glu Lys Thr Gly Leu Glu 
            20                  25                  30          

Asn Leu Thr Glu Gly Ser Ile Ala Ile Asp Gly Asn Arg Leu Phe Gly 
        35                  40                  45              

Asn Cys Phe Thr Tyr Leu Ala Asp Gly Gln Ala Gly Ala Phe Phe Glu 
    50                  55                  60                  

Thr His Gln Lys Tyr Leu Asp Ile His Leu Val Leu Glu Asn Glu Glu 
65                  70                  75                  80  

Ala Met Ala Val Thr Ser Pro Glu Asn Val Ser Val Thr Gln Glu Tyr 
                85                  90                  95      

Asp Glu Glu Lys Asp Ile Glu Leu Tyr Thr Gly Lys Val Glu Gln Leu 
            100                 105                 110         

Val His Leu Arg Ala Gly Glu Cys Leu Ile Thr Phe Pro Glu Asp Leu 
        115                 120                 125             

His Gln Pro Lys Val Arg Ile Asn Asp Glu Pro Val Lys Lys Val Val 
    130                 135                 140                 

Phe Lys Val Ala Ile Ser 
145                 150 

<210>   3483
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3483
ttgaaaatct cttcaaacca cagtcgcttc accttggatt atataggtca gtcttatcta   60
caacctcaaa gcggtgtttt gggcaatctg ctactagctt gc                      102

<210>   3484
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3484
Met Lys Ile Ser Ser Asn His Ser Arg Phe Thr Leu Asp Tyr Ile Gly 
1               5                   10                  15      

Gln Ser Tyr Leu Gln Pro Gln Ser Gly Val Leu Gly Asn Leu Leu Leu 
            20                  25                  30          

Ala Cys 
        

<210>   3485
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3485
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accttctaaa   180
attccttatc ttgaaacgac tggtatgcct actagaattc tccttagaaa gcgtcgattc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ctatcgtcaa gaagaatcac   300
caaatccctc gtatcatcaa ccaaaaaatt gctcaaaagt taattgaaaa gatttctatg   360
actgatattg cccatcagct ttccatctca acttcaactg ttattcgtaa gctcaatgac   420
tttcacttta aacatgattt ttcttgtctt cctgagatta tgtcttggga tgagtatgct   480
tttacaaagg gaaagatgag cttcattgcg caagatttta acaatctcaa tatcatcact   540
gttcttgagg gaagaacaca agctatcatt cgaaatcact ttcttaaata tgatagagcc   600
gtccgatgtc gcgtcaaaat tattactatg gatatgttta gtccttacta tgacttagct   660
agacaacttt tcccatgtgc taaaatcgtg ttggatcgct ttcacattgt acaacatctt   720
agccgtgcta tgagtcgtgt gcgtgttcaa atcatgaatc aattggatcg aaagtctcat   780
gaatacaagg ctatcaagcg ctactggaag ctcatacaac aggatagtcg taaactcagc   840
gataaacatt tttatcgccc tacttttcgt atgcatttaa ccaataaaga gattttaaac   900
aagcttttga gctattcaca agacttgaaa catcactatc agctctatca actcttgctg   960
tttcactttc agaataagga accggagaaa tttttcggac tcattgagga caatctaaag   1020
caggttcatc ctctttttca gactgtcttt aaaacctttc taaaggacaa agagaaaatc   1080
gtcaacgccc ttcaactaca ctattctaac gccaaattgg aagcgaccaa taatctcatc   1140
aaacttatca agcgcaatgc ctttggtttt cggaactttg aaaacttcaa aaaacggatt   1200
tttatcgctc tgaatatcaa aaaagaaagg acaaaatttg tcctttctcg agct         1254

<210>   3486
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903763 (0.E+01)

<400>   3486
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ser 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Lys 
    130                 135                 140                 

His Asp Phe Ser Cys Leu Pro Glu Ile Met Ser Trp Asp Glu Tyr Ala 
145                 150                 155                 160 

Phe Thr Lys Gly Lys Met Ser Phe Ile Ala Gln Asp Phe Asn Asn Leu 
                165                 170                 175     

Asn Ile Ile Thr Val Leu Glu Gly Arg Thr Gln Ala Ile Ile Arg Asn 
            180                 185                 190         

His Phe Leu Lys Tyr Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile 
        195                 200                 205             

Thr Met Asp Met Phe Ser Pro Tyr Tyr Asp Leu Ala Arg Gln Leu Phe 
    210                 215                 220                 

Pro Cys Ala Lys Ile Val Leu Asp Arg Phe His Ile Val Gln His Leu 
225                 230                 235                 240 

Ser Arg Ala Met Ser Arg Val Arg Val Gln Ile Met Asn Gln Leu Asp 
                245                 250                 255     

Arg Lys Ser His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile 
            260                 265                 270         

Gln Gln Asp Ser Arg Lys Leu Ser Asp Lys His Phe Tyr Arg Pro Thr 
        275                 280                 285             

Phe Arg Met His Leu Thr Asn Lys Glu Ile Leu Asn Lys Leu Leu Ser 
    290                 295                 300                 

Tyr Ser Gln Asp Leu Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu 
305                 310                 315                 320 

Phe His Phe Gln Asn Lys Glu Pro Glu Lys Phe Phe Gly Leu Ile Glu 
                325                 330                 335     

Asp Asn Leu Lys Gln Val His Pro Leu Phe Gln Thr Val Phe Lys Thr 
            340                 345                 350         

Phe Leu Lys Asp Lys Glu Lys Ile Val Asn Ala Leu Gln Leu His Tyr 
        355                 360                 365             

Ser Asn Ala Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys 
    370                 375                 380                 

Arg Asn Ala Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile 
385                 390                 395                 400 

Phe Ile Ala Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser 
                405                 410                 415     

Arg Ala 
        

<210>   3487
<211>   2400
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3487
atgtcttatt tcagaaatcg ggatatagat atagagagga tcagtatgaa tcggagtgtt   60
caagaacgta agtgtcgtta tagcattagg aaactatcgg taggagcggt ttctatgatt   120
gtaggagcag tggtatttgg aacgtctcct gttttagctc aagaaggggc aagtgagcaa   180
cctctggcaa atgaaactca actttcgggg gagagctcaa ccctaactga tacagaaaag   240
agccagcctt cttcagagac tgaactttct ggcaataagc aagaacaaga aaggaaagat   300
aagcaagaag aaaaaattcc aagagattac tatgcacgag atttggaaaa tgtcgaaaca   360
gtgatagaaa aagaagatgt tgaaaccaat gcttcaaatg gtcagagagt tgatttatca   420
agtgaactag ataaactaaa gaaacttgaa aacgcaacag ttcacatgga gtttaagcca   480
gatgccaagg ccccagcatt ctataatctc ttttctgtgt caagtgctac taaaaaagat   540
gagtacttca ctatggcagt ttacaataat actgctactc tagaggggcg tggttcggat   600
gggaaacagt tttacaataa ttacaacgat gcacccttaa aagttaaacc aggtcagtgg   660
aattctgtga ctttcacagt tgaaaaaccg acagcagaac tacctaaagg ccgagtgcgc   720
ctctacgtaa acggggtatt atctcgaaca agtctgagat ctggcaattt cattaaagat   780
atgccagatg taacgcatgt gcaaatcgga gcaaccaagc gtgccaacaa tacggtttgg   840
gggtcaaatc tacagattcg gaatctcact gtgtataatc gtgctttaac accagaagag   900
gtacaaaaac gtagtcaact ttttaaacgc tcagatttag aaaaaaaact acctgaagga   960
gcggctttaa cagagaaaac ggacatattc gaaagcgggc gtaacggtaa cccaaataaa   1020
gatggaatca agagttatcg tattccagca cttctcaaga cagataaagg aactttgatc   1080
gcaggtgcag atgaacgccg tctccattcg agtgactggg gtgatatcgg tatggtcatc   1140
agacgtagtg aagataatgg taaaacttgg ggtgaccgag taaccattac caacttacgt   1200
gacaatccaa aagcttctga cccatcgatc ggttcaccag tgaatatcga tatggtgttg   1260
gttcaagatc ctgaaaccaa acgaatcttt tctatctatg acatgttccc agaagggaag   1320
ggaatctttg gaatgtcttc acaaaaagaa gaagcctaca aaaaaatcga tggaaaaacc   1380
tatcaaatcc tctaccgtga aggagaaaag ggagcttata ccattcgaga aaatggtact   1440
gtctatacac cagatggtaa ggcgacagac tatcgcgttg ttgtagatcc tgttaaacca   1500
gcctatagcg acaagggtga tctatacaag ggtgaccaat tactaggaaa tatctacttc   1560
acaacaaaca aaacttctcc atttagaatt gccaaggata gctatctatg gatgtcctac   1620
agtgatgacg acgggaagac atggtcagct cctcaagata ttactccgat ggtcaaagcc   1680
gattggatga aattcttggg tgtaggtcct ggaacaggaa ttgtacttcg gaatgggcct   1740
cacaagggac ggattttgat accggtttat acgactaata atgtatctca cttagatggc   1800
tcgcaatctt ctcgtgtcat ctattcagat gatcatggaa aaacttggca tgctggagaa   1860
gcggtcaacg ataaccgtca ggtagacggt caaaagatcc actcttctac gatgaacaat   1920
agacgtgcgc aaaatacaga atcaacggtg gtacaactaa acaatggaga tgttaaactc   1980
tttatgcgtg gtttgactgg agatcttcag gttgctacaa gtaaagacgg aggagtgact   2040
tgggagaagg atatcaaacg ttatccacag gttaaagatg tctatgttca aatgtctgct   2100
atccatacga tgcacgaagg aaaagaatac atcatcctca gtaatgcagg tggaccgaaa   2160
cgtgaaaatg ggatggtcca cttggcacgt gtcgaagaaa atggtgagtt gacttggctc   2220
aaacacaatc caattcaaaa aggagagttt gcctataatt cgctccaaga attaggaaat   2280
ggggagtatg gcatcttgta tgaacatact gaaaaaggac aaaatgccta taccctatca   2340
tttagaaaat ttaattggga atttttgagc aaaaatctga tttctcctac cgaagcgaac   2400

<210>   3488
<211>   800
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   neuraminidase A FRAMESHIFT (nanA)

<400>   3488
Met Ser Tyr Phe Arg Asn Arg Asp Ile Asp Ile Glu Arg Ile Ser Met 
1               5                   10                  15      

Asn Arg Ser Val Gln Glu Arg Lys Cys Arg Tyr Ser Ile Arg Lys Leu 
            20                  25                  30          

Ser Val Gly Ala Val Ser Met Ile Val Gly Ala Val Val Phe Gly Thr 
        35                  40                  45              

Ser Pro Val Leu Ala Gln Glu Gly Ala Ser Glu Gln Pro Leu Ala Asn 
    50                  55                  60                  

Glu Thr Gln Leu Ser Gly Glu Ser Ser Thr Leu Thr Asp Thr Glu Lys 
65                  70                  75                  80  

Ser Gln Pro Ser Ser Glu Thr Glu Leu Ser Gly Asn Lys Gln Glu Gln 
                85                  90                  95      

Glu Arg Lys Asp Lys Gln Glu Glu Lys Ile Pro Arg Asp Tyr Tyr Ala 
            100                 105                 110         

Arg Asp Leu Glu Asn Val Glu Thr Val Ile Glu Lys Glu Asp Val Glu 
        115                 120                 125             

Thr Asn Ala Ser Asn Gly Gln Arg Val Asp Leu Ser Ser Glu Leu Asp 
    130                 135                 140                 

Lys Leu Lys Lys Leu Glu Asn Ala Thr Val His Met Glu Phe Lys Pro 
145                 150                 155                 160 

Asp Ala Lys Ala Pro Ala Phe Tyr Asn Leu Phe Ser Val Ser Ser Ala 
                165                 170                 175     

Thr Lys Lys Asp Glu Tyr Phe Thr Met Ala Val Tyr Asn Asn Thr Ala 
            180                 185                 190         

Thr Leu Glu Gly Arg Gly Ser Asp Gly Lys Gln Phe Tyr Asn Asn Tyr 
        195                 200                 205             

Asn Asp Ala Pro Leu Lys Val Lys Pro Gly Gln Trp Asn Ser Val Thr 
    210                 215                 220                 

Phe Thr Val Glu Lys Pro Thr Ala Glu Leu Pro Lys Gly Arg Val Arg 
225                 230                 235                 240 

Leu Tyr Val Asn Gly Val Leu Ser Arg Thr Ser Leu Arg Ser Gly Asn 
                245                 250                 255     

Phe Ile Lys Asp Met Pro Asp Val Thr His Val Gln Ile Gly Ala Thr 
            260                 265                 270         

Lys Arg Ala Asn Asn Thr Val Trp Gly Ser Asn Leu Gln Ile Arg Asn 
        275                 280                 285             

Leu Thr Val Tyr Asn Arg Ala Leu Thr Pro Glu Glu Val Gln Lys Arg 
    290                 295                 300                 

Ser Gln Leu Phe Lys Arg Ser Asp Leu Glu Lys Lys Leu Pro Glu Gly 
305                 310                 315                 320 

Ala Ala Leu Thr Glu Lys Thr Asp Ile Phe Glu Ser Gly Arg Asn Gly 
                325                 330                 335     

Asn Pro Asn Lys Asp Gly Ile Lys Ser Tyr Arg Ile Pro Ala Leu Leu 
            340                 345                 350         

Lys Thr Asp Lys Gly Thr Leu Ile Ala Gly Ala Asp Glu Arg Arg Leu 
        355                 360                 365             

His Ser Ser Asp Trp Gly Asp Ile Gly Met Val Ile Arg Arg Ser Glu 
    370                 375                 380                 

Asp Asn Gly Lys Thr Trp Gly Asp Arg Val Thr Ile Thr Asn Leu Arg 
385                 390                 395                 400 

Asp Asn Pro Lys Ala Ser Asp Pro Ser Ile Gly Ser Pro Val Asn Ile 
                405                 410                 415     

Asp Met Val Leu Val Gln Asp Pro Glu Thr Lys Arg Ile Phe Ser Ile 
            420                 425                 430         

Tyr Asp Met Phe Pro Glu Gly Lys Gly Ile Phe Gly Met Ser Ser Gln 
        435                 440                 445             

Lys Glu Glu Ala Tyr Lys Lys Ile Asp Gly Lys Thr Tyr Gln Ile Leu 
    450                 455                 460                 

Tyr Arg Glu Gly Glu Lys Gly Ala Tyr Thr Ile Arg Glu Asn Gly Thr 
465                 470                 475                 480 

Val Tyr Thr Pro Asp Gly Lys Ala Thr Asp Tyr Arg Val Val Val Asp 
                485                 490                 495     

Pro Val Lys Pro Ala Tyr Ser Asp Lys Gly Asp Leu Tyr Lys Gly Asp 
            500                 505                 510         

Gln Leu Leu Gly Asn Ile Tyr Phe Thr Thr Asn Lys Thr Ser Pro Phe 
        515                 520                 525             

Arg Ile Ala Lys Asp Ser Tyr Leu Trp Met Ser Tyr Ser Asp Asp Asp 
    530                 535                 540                 

Gly Lys Thr Trp Ser Ala Pro Gln Asp Ile Thr Pro Met Val Lys Ala 
545                 550                 555                 560 

Asp Trp Met Lys Phe Leu Gly Val Gly Pro Gly Thr Gly Ile Val Leu 
                565                 570                 575     

Arg Asn Gly Pro His Lys Gly Arg Ile Leu Ile Pro Val Tyr Thr Thr 
            580                 585                 590         

Asn Asn Val Ser His Leu Asp Gly Ser Gln Ser Ser Arg Val Ile Tyr 
        595                 600                 605             

Ser Asp Asp His Gly Lys Thr Trp His Ala Gly Glu Ala Val Asn Asp 
    610                 615                 620                 

Asn Arg Gln Val Asp Gly Gln Lys Ile His Ser Ser Thr Met Asn Asn 
625                 630                 635                 640 

Arg Arg Ala Gln Asn Thr Glu Ser Thr Val Val Gln Leu Asn Asn Gly 
                645                 650                 655     

Asp Val Lys Leu Phe Met Arg Gly Leu Thr Gly Asp Leu Gln Val Ala 
            660                 665                 670         

Thr Ser Lys Asp Gly Gly Val Thr Trp Glu Lys Asp Ile Lys Arg Tyr 
        675                 680                 685             

Pro Gln Val Lys Asp Val Tyr Val Gln Met Ser Ala Ile His Thr Met 
    690                 695                 700                 

His Glu Gly Lys Glu Tyr Ile Ile Leu Ser Asn Ala Gly Gly Pro Lys 
705                 710                 715                 720 

Arg Glu Asn Gly Met Val His Leu Ala Arg Val Glu Glu Asn Gly Glu 
                725                 730                 735     

Leu Thr Trp Leu Lys His Asn Pro Ile Gln Lys Gly Glu Phe Ala Tyr 
            740                 745                 750         

Asn Ser Leu Gln Glu Leu Gly Asn Gly Glu Tyr Gly Ile Leu Tyr Glu 
        755                 760                 765             

His Thr Glu Lys Gly Gln Asn Ala Tyr Thr Leu Ser Phe Arg Lys Phe 
    770                 775                 780                 

Asn Trp Glu Phe Leu Ser Lys Asn Leu Ile Ser Pro Thr Glu Ala Asn 
785                 790                 795                 800 


<210>   3489
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3489
atgatattta aggcattcaa gacaaaaaag cagagaaaaa gacaagttga actacttttg   60
acagtttttt tcgacagttt tctgattgat ttatttcttc acttatttgg gattgtcccc   120
tttaagctgg ataagattct gattgtgagc ttgattatat ttcccattat ttctacaagt   180
atttatgctt atgaaaagct atttgaaaaa gtgttcgata aggat                   225

<210>   3490
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903580 (8.E-38)

<400>   3490
Met Ile Phe Lys Ala Phe Lys Thr Lys Lys Gln Arg Lys Arg Gln Val 
1               5                   10                  15      

Glu Leu Leu Leu Thr Val Phe Phe Asp Ser Phe Leu Ile Asp Leu Phe 
            20                  25                  30          

Leu His Leu Phe Gly Ile Val Pro Phe Lys Leu Asp Lys Ile Leu Ile 
        35                  40                  45              

Val Ser Leu Ile Ile Phe Pro Ile Ile Ser Thr Ser Ile Tyr Ala Tyr 
    50                  55                  60                  

Glu Lys Leu Phe Glu Lys Val Phe Asp Lys Asp 
65                  70                  75  

<210>   3491
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3491
gtgttaatac ttttcaaaaa tctcttcaaa ccacgtcagc ttcgccttgc cgtaggtatg   60
gttactgact tcgtcagttc tatccacaac ctcaaaacag tgttt                   105

<210>   3492
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3492
Met Leu Ile Leu Phe Lys Asn Leu Phe Lys Pro Arg Gln Leu Arg Leu 
1               5                   10                  15      

Ala Val Gly Met Val Thr Asp Phe Val Ser Ser Ile His Asn Leu Lys 
            20                  25                  30          

Thr Val Phe 
        35  

<210>   3493
<211>   978
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3493
atgaaaaatc cagctttgct agaagaaatt aagacctata gaggaaggga tgaggttccg   60
gaagactttg atgatttctg ggatggggaa gtgaaaaatg tttccacgct tccatcctac   120
cacttggagg aaagagattt ccacattcct caagtcaagt gctatgagtt aacatttgaa   180
ggaagcaagg aaggaaaggt ctatgcacgc attgttcttc caaagagtga ggagaaggtc   240
ccattaatct tccattttca tggttatatg ggacgtggct gggactgggc cgacatgctg   300
ggcttcaccg tagctggtta cggtgttgtt tccatggatg tgcggggcca gtcaggttac   360
tcacaagacg gcttgcgttc tcctttagga aataccgtga aggggcatat tatccgtggt   420
gctgtggaag gtcgggacca cctcttttat aaggatgttt atctggatat ttaccagttg   480
gtcgaaattg ttgctagtct gtctcaggtt gatgagaagc gtctttctag ctatggtgcc   540
tcacaaggag gggctctagc tctagttgca gcagcgctca atcctcgaat tcagaaaaca   600
gttgccattt atcccttctt gtcagacttc agacgggtga ttgagattgg taatactagc   660
gaggcttacg acgaactttt ccgttatttc aagtttcacg accccttcca tgaaacagag   720
gaggaaatca tggcgaccct tgcctatatc gatgtcaaaa atcttgccca tcgtatccaa   780
ggtgaggtta agatgattac gggcttggac gacgatgttt gctatcccat tacccagttt   840
gcgatttata atcgtctgac ctgcgataaa acctatcgca tcatgcctga gtatgctcac   900
gaagccatga atgtatttgt caatgaccaa gtctacaact ggctctgtgg aagtgagatt   960
ccttttaaat atctaaaa                                                 978

<210>   3494
<211>   326
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyl xylan esterase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903581 (0.E+01)

<400>   3494
Met Lys Asn Pro Ala Leu Leu Glu Glu Ile Lys Thr Tyr Arg Gly Arg 
1               5                   10                  15      

Asp Glu Val Pro Glu Asp Phe Asp Asp Phe Trp Asp Gly Glu Val Lys 
            20                  25                  30          

Asn Val Ser Thr Leu Pro Ser Tyr His Leu Glu Glu Arg Asp Phe His 
        35                  40                  45              

Ile Pro Gln Val Lys Cys Tyr Glu Leu Thr Phe Glu Gly Ser Lys Glu 
    50                  55                  60                  

Gly Lys Val Tyr Ala Arg Ile Val Leu Pro Lys Ser Glu Glu Lys Val 
65                  70                  75                  80  

Pro Leu Ile Phe His Phe His Gly Tyr Met Gly Arg Gly Trp Asp Trp 
                85                  90                  95      

Ala Asp Met Leu Gly Phe Thr Val Ala Gly Tyr Gly Val Val Ser Met 
            100                 105                 110         

Asp Val Arg Gly Gln Ser Gly Tyr Ser Gln Asp Gly Leu Arg Ser Pro 
        115                 120                 125             

Leu Gly Asn Thr Val Lys Gly His Ile Ile Arg Gly Ala Val Glu Gly 
    130                 135                 140                 

Arg Asp His Leu Phe Tyr Lys Asp Val Tyr Leu Asp Ile Tyr Gln Leu 
145                 150                 155                 160 

Val Glu Ile Val Ala Ser Leu Ser Gln Val Asp Glu Lys Arg Leu Ser 
                165                 170                 175     

Ser Tyr Gly Ala Ser Gln Gly Gly Ala Leu Ala Leu Val Ala Ala Ala 
            180                 185                 190         

Leu Asn Pro Arg Ile Gln Lys Thr Val Ala Ile Tyr Pro Phe Leu Ser 
        195                 200                 205             

Asp Phe Arg Arg Val Ile Glu Ile Gly Asn Thr Ser Glu Ala Tyr Asp 
    210                 215                 220                 

Glu Leu Phe Arg Tyr Phe Lys Phe His Asp Pro Phe His Glu Thr Glu 
225                 230                 235                 240 

Glu Glu Ile Met Ala Thr Leu Ala Tyr Ile Asp Val Lys Asn Leu Ala 
                245                 250                 255     

His Arg Ile Gln Gly Glu Val Lys Met Ile Thr Gly Leu Asp Asp Asp 
            260                 265                 270         

Val Cys Tyr Pro Ile Thr Gln Phe Ala Ile Tyr Asn Arg Leu Thr Cys 
        275                 280                 285             

Asp Lys Thr Tyr Arg Ile Met Pro Glu Tyr Ala His Glu Ala Met Asn 
    290                 295                 300                 

Val Phe Val Asn Asp Gln Val Tyr Asn Trp Leu Cys Gly Ser Glu Ile 
305                 310                 315                 320 

Pro Phe Lys Tyr Leu Lys 
                325     

<210>   3495
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3495
ttggctctta tactagagtc atcaaaaaga aacgaggact ctcatatgac agtaacgatt   60
aaagtaaatt accaaaccac tttccaaaag aaggaagcaa aaaac                   105

<210>   3496
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3496
Met Ala Leu Ile Leu Glu Ser Ser Lys Arg Asn Glu Asp Ser His Met 
1               5                   10                  15      

Thr Val Thr Ile Lys Val Asn Tyr Gln Thr Thr Phe Gln Lys Lys Glu 
            20                  25                  30          

Ala Lys Asn 
        35  

<210>   3497
<211>   147
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3497
atgaaaatca aagagcaaac taggaagcta accgcaggtt gctcaaaaca ctgttttgag   60
gttgtggatg aaactgacga agtcagctca aaacaccgtt ttgaggtggc agatagaact   120
gacgaagtca gtaacatata tatacgg                                       147

<210>   3498
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3498
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Thr Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Arg Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser Asn Ile Tyr Ile 
        35                  40                  45              

Arg 
    

<210>   3499
<211>   2013
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3499
atgaatctac atcaaccctt gcatgtcttg cctggtgtgg gaccaaagtc agcagaaaaa   60
tacgccaaac taggaattga aaacttgcaa gatctcttgc tctactttcc tttccgttat   120
gaagacttca aaaccaagca ggtgctggag ctggaagacg gtgagaaggc agttctttct   180
ggtcaggtag tgactcctgc tagtgtccag tattatggtt tcaagcgcaa tcgcctgcgt   240
tttagtctca agcagggaga ggtcgttttt gcggtgaatt tctttaacca gccctatctg   300
gctgataaaa tagagttggg agcaaccctt gctgtctttg gaaaatggga ccgcgctaag   360
gctagtctga ctgggatgaa ggttctggct caggtagaag atgacctcca gcctgtctat   420
cgtctggctc agggaatcag tcaggccagt ctggtcaagg tcatcaagac ggcttttgat   480
cagggactgg acctcttgat agaagaaaat ctgccccagt ctttactaga caaatacaaa   540
ctcatgtccc gttgtcaggc agtccgtgct atgcattttc caaagtattt ggcagaatac   600
aagcaggctc ttcgccgtat aaagtttgag gaactctttt atttccaaat gcagctgcag   660
atgctcaagt ctgaaaatag agttcaggga agtggtctgg ttctgaattg gtctcaggaa   720
aaagtgacag cagttaaagt aagtcttcct tttgccctga cccaagctca ggaaaagagt   780
ttgcaggaaa ttttaactga tatgaagtcc gaccaccaca tgaatcgtct cctacaaggg   840
gatgtgggga gtggaaaaac ggtagtcgct ggcttggcca tgtttgcggc agtgacagca   900
ggttatcagg ctgccctaat ggtaccaaca gaaatcctcg cagagcaaca ctttgagagt   960
ttacagaacc tttttcccaa tttgaaactg gctctcttga caggttcctt gaaagctgca   1020
gaaaagagag aagtcttgga gaccattgcc aagggtgagg ctgatttgat tataggaact   1080
cacgctctga tacaagatgg ggtggagtat gctcgtcttg gtttgattat tatcgatgag   1140
cagcaccgtt ttggtgtagg gcaaaggcgt attttacggg aaaaaggtga caatccagat   1200
gtcctcatga tgacggcgac tcccattcca cggacgcttg ccatcacagc ctttggagat   1260
atggatgttt ccattatcga ccagatgcca gcaggtcgga agcctattgt gacgcgctgg   1320
atcaaacatg agcaactacc tcaggtcttg acttggttag agggggaaat tcaaaaaggt   1380
tcccaagtct atgtcatctc tcctttgatt gaagaatcag aagctctaga tttgaaaaat   1440
gccattgcct tatcagagga gttgacgact cattttgcag gcaaggcaga ggtggctctt   1500
ctacatggta ggatgaagag tgacgaaaaa gaccagatca tgcaggattt caaggagaga   1560
aagacggata ttctggtttc gacgacggtt attgaggttg gggtcaacgt tcccaatgcg   1620
actgtcatga ttatcatgga tgccgatcgc ttcggtctca gtcaacttca ccagcttaga   1680
ggtcgtgtcg gtcgggggga caagcagtcc tacgctgttc tcgttgctaa tcccaagacg   1740
gattctggga aagaccgcat gcgtatcatg acagaaacga ccaatggatt tgtccttgcg   1800
gaggaagatt tgaaaatgcg tggttctggt gagatttttg gaaccagaca gtcaggactt   1860
ccagagttcc aagtggctga tattatcgaa gattttccga ttttagaaga agcaagaaag   1920
gttgctagct acattagttc tatagaagct tggcaagaag atccagagtg gcgcatgatt   1980
gcccttcatc tggaaaagaa agaacatctg gat                                2013

<210>   3500
<211>   671
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent DNA helicase RecG (recG)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903582 (0.E+01)

<400>   3500
Met Asn Leu His Gln Pro Leu His Val Leu Pro Gly Val Gly Pro Lys 
1               5                   10                  15      

Ser Ala Glu Lys Tyr Ala Lys Leu Gly Ile Glu Asn Leu Gln Asp Leu 
            20                  25                  30          

Leu Leu Tyr Phe Pro Phe Arg Tyr Glu Asp Phe Lys Thr Lys Gln Val 
        35                  40                  45              

Leu Glu Leu Glu Asp Gly Glu Lys Ala Val Leu Ser Gly Gln Val Val 
    50                  55                  60                  

Thr Pro Ala Ser Val Gln Tyr Tyr Gly Phe Lys Arg Asn Arg Leu Arg 
65                  70                  75                  80  

Phe Ser Leu Lys Gln Gly Glu Val Val Phe Ala Val Asn Phe Phe Asn 
                85                  90                  95      

Gln Pro Tyr Leu Ala Asp Lys Ile Glu Leu Gly Ala Thr Leu Ala Val 
            100                 105                 110         

Phe Gly Lys Trp Asp Arg Ala Lys Ala Ser Leu Thr Gly Met Lys Val 
        115                 120                 125             

Leu Ala Gln Val Glu Asp Asp Leu Gln Pro Val Tyr Arg Leu Ala Gln 
    130                 135                 140                 

Gly Ile Ser Gln Ala Ser Leu Val Lys Val Ile Lys Thr Ala Phe Asp 
145                 150                 155                 160 

Gln Gly Leu Asp Leu Leu Ile Glu Glu Asn Leu Pro Gln Ser Leu Leu 
                165                 170                 175     

Asp Lys Tyr Lys Leu Met Ser Arg Cys Gln Ala Val Arg Ala Met His 
            180                 185                 190         

Phe Pro Lys Tyr Leu Ala Glu Tyr Lys Gln Ala Leu Arg Arg Ile Lys 
        195                 200                 205             

Phe Glu Glu Leu Phe Tyr Phe Gln Met Gln Leu Gln Met Leu Lys Ser 
    210                 215                 220                 

Glu Asn Arg Val Gln Gly Ser Gly Leu Val Leu Asn Trp Ser Gln Glu 
225                 230                 235                 240 

Lys Val Thr Ala Val Lys Val Ser Leu Pro Phe Ala Leu Thr Gln Ala 
                245                 250                 255     

Gln Glu Lys Ser Leu Gln Glu Ile Leu Thr Asp Met Lys Ser Asp His 
            260                 265                 270         

His Met Asn Arg Leu Leu Gln Gly Asp Val Gly Ser Gly Lys Thr Val 
        275                 280                 285             

Val Ala Gly Leu Ala Met Phe Ala Ala Val Thr Ala Gly Tyr Gln Ala 
    290                 295                 300                 

Ala Leu Met Val Pro Thr Glu Ile Leu Ala Glu Gln His Phe Glu Ser 
305                 310                 315                 320 

Leu Gln Asn Leu Phe Pro Asn Leu Lys Leu Ala Leu Leu Thr Gly Ser 
                325                 330                 335     

Leu Lys Ala Ala Glu Lys Arg Glu Val Leu Glu Thr Ile Ala Lys Gly 
            340                 345                 350         

Glu Ala Asp Leu Ile Ile Gly Thr His Ala Leu Ile Gln Asp Gly Val 
        355                 360                 365             

Glu Tyr Ala Arg Leu Gly Leu Ile Ile Ile Asp Glu Gln His Arg Phe 
    370                 375                 380                 

Gly Val Gly Gln Arg Arg Ile Leu Arg Glu Lys Gly Asp Asn Pro Asp 
385                 390                 395                 400 

Val Leu Met Met Thr Ala Thr Pro Ile Pro Arg Thr Leu Ala Ile Thr 
                405                 410                 415     

Ala Phe Gly Asp Met Asp Val Ser Ile Ile Asp Gln Met Pro Ala Gly 
            420                 425                 430         

Arg Lys Pro Ile Val Thr Arg Trp Ile Lys His Glu Gln Leu Pro Gln 
        435                 440                 445             

Val Leu Thr Trp Leu Glu Gly Glu Ile Gln Lys Gly Ser Gln Val Tyr 
    450                 455                 460                 

Val Ile Ser Pro Leu Ile Glu Glu Ser Glu Ala Leu Asp Leu Lys Asn 
465                 470                 475                 480 

Ala Ile Ala Leu Ser Glu Glu Leu Thr Thr His Phe Ala Gly Lys Ala 
                485                 490                 495     

Glu Val Ala Leu Leu His Gly Arg Met Lys Ser Asp Glu Lys Asp Gln 
            500                 505                 510         

Ile Met Gln Asp Phe Lys Glu Arg Lys Thr Asp Ile Leu Val Ser Thr 
        515                 520                 525             

Thr Val Ile Glu Val Gly Val Asn Val Pro Asn Ala Thr Val Met Ile 
    530                 535                 540                 

Ile Met Asp Ala Asp Arg Phe Gly Leu Ser Gln Leu His Gln Leu Arg 
545                 550                 555                 560 

Gly Arg Val Gly Arg Gly Asp Lys Gln Ser Tyr Ala Val Leu Val Ala 
                565                 570                 575     

Asn Pro Lys Thr Asp Ser Gly Lys Asp Arg Met Arg Ile Met Thr Glu 
            580                 585                 590         

Thr Thr Asn Gly Phe Val Leu Ala Glu Glu Asp Leu Lys Met Arg Gly 
        595                 600                 605             

Ser Gly Glu Ile Phe Gly Thr Arg Gln Ser Gly Leu Pro Glu Phe Gln 
    610                 615                 620                 

Val Ala Asp Ile Ile Glu Asp Phe Pro Ile Leu Glu Glu Ala Arg Lys 
625                 630                 635                 640 

Val Ala Ser Tyr Ile Ser Ser Ile Glu Ala Trp Gln Glu Asp Pro Glu 
                645                 650                 655     

Trp Arg Met Ile Ala Leu His Leu Glu Lys Lys Glu His Leu Asp 
            660                 665                 670     

<210>   3501
<211>   1122
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3501
gtgtcatttt ggaggaaaat catgaaagct agtccacata gaccaaccaa ggctctgatt   60
catctgggag ctattcgaca aaatattcag caaatggggg ctcatatccc tcaaggaacg   120
ctcaagttgg ctgtggttaa ggccaatgct tatggtcatg gagctgttgc cgttgccaag   180
gcaattcaag atgatgttga tggcttttgc gtttccaata tcgatgaagc cattgaactc   240
agacaagctg gactcagcaa gccaatcctc attttaggag tttctgaaat cgaagctgtt   300
gctctagcta aagaatatga cttcaccttg acagtggctg gactggagtg gattcaagca   360
ctcttagata aggaagtgga cctaactgga ttgacagtcc acctcaagat tgattcaggg   420
atgggacgga ttggttttag agaggcaagt gaggttgagc aggctcaaga tttgctccaa   480
caacacggtg tttgtgttga aggaatcttt acccactttg ctactgctga tgaggaatca   540
gatgactatt ttaatgccca gttagaacgg tttaaaacta ttttagctag tatgaaggaa   600
gttccagagc tggttcatgc tagcaattct gcaacgactc tttggcatgt agagactatt   660
ttcaatgcgg ttcgtatggg agatgccatg tatggcctca atccaagtgg agcggtcttg   720
gatttgcctt atgatttgat accggccttg accttggagt ctgctctggt tcatgtcaag   780
acagttccag ctggagcttg catgggctat ggagcaactt atcaagcgga tagcgagcaa   840
gtcatcgcga ccgtgccaat cgggtatgca gatggatgga caagagacat gcaaaatttc   900
tctgtcttgg tagatggcca agcttgccca attgtcggca gggtttcgat ggaccaaatc   960
actattcgat tgcctaagct ttatccgcta ggaaccaagg taaccttgat tggctccaat   1020
ggggataagg aaatcactgc aactcaggta gcgacctacc gcgtaaccat taactatgag   1080
gtggtttgcc tcctcagcga ccgtattccg agagaatatt at                      1122

<210>   3502
<211>   374
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alanine racemase (alr)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903583 (0.E+01)

<400>   3502
Met Ser Phe Trp Arg Lys Ile Met Lys Ala Ser Pro His Arg Pro Thr 
1               5                   10                  15      

Lys Ala Leu Ile His Leu Gly Ala Ile Arg Gln Asn Ile Gln Gln Met 
            20                  25                  30          

Gly Ala His Ile Pro Gln Gly Thr Leu Lys Leu Ala Val Val Lys Ala 
        35                  40                  45              

Asn Ala Tyr Gly His Gly Ala Val Ala Val Ala Lys Ala Ile Gln Asp 
    50                  55                  60                  

Asp Val Asp Gly Phe Cys Val Ser Asn Ile Asp Glu Ala Ile Glu Leu 
65                  70                  75                  80  

Arg Gln Ala Gly Leu Ser Lys Pro Ile Leu Ile Leu Gly Val Ser Glu 
                85                  90                  95      

Ile Glu Ala Val Ala Leu Ala Lys Glu Tyr Asp Phe Thr Leu Thr Val 
            100                 105                 110         

Ala Gly Leu Glu Trp Ile Gln Ala Leu Leu Asp Lys Glu Val Asp Leu 
        115                 120                 125             

Thr Gly Leu Thr Val His Leu Lys Ile Asp Ser Gly Met Gly Arg Ile 
    130                 135                 140                 

Gly Phe Arg Glu Ala Ser Glu Val Glu Gln Ala Gln Asp Leu Leu Gln 
145                 150                 155                 160 

Gln His Gly Val Cys Val Glu Gly Ile Phe Thr His Phe Ala Thr Ala 
                165                 170                 175     

Asp Glu Glu Ser Asp Asp Tyr Phe Asn Ala Gln Leu Glu Arg Phe Lys 
            180                 185                 190         

Thr Ile Leu Ala Ser Met Lys Glu Val Pro Glu Leu Val His Ala Ser 
        195                 200                 205             

Asn Ser Ala Thr Thr Leu Trp His Val Glu Thr Ile Phe Asn Ala Val 
    210                 215                 220                 

Arg Met Gly Asp Ala Met Tyr Gly Leu Asn Pro Ser Gly Ala Val Leu 
225                 230                 235                 240 

Asp Leu Pro Tyr Asp Leu Ile Pro Ala Leu Thr Leu Glu Ser Ala Leu 
                245                 250                 255     

Val His Val Lys Thr Val Pro Ala Gly Ala Cys Met Gly Tyr Gly Ala 
            260                 265                 270         

Thr Tyr Gln Ala Asp Ser Glu Gln Val Ile Ala Thr Val Pro Ile Gly 
        275                 280                 285             

Tyr Ala Asp Gly Trp Thr Arg Asp Met Gln Asn Phe Ser Val Leu Val 
    290                 295                 300                 

Asp Gly Gln Ala Cys Pro Ile Val Gly Arg Val Ser Met Asp Gln Ile 
305                 310                 315                 320 

Thr Ile Arg Leu Pro Lys Leu Tyr Pro Leu Gly Thr Lys Val Thr Leu 
                325                 330                 335     

Ile Gly Ser Asn Gly Asp Lys Glu Ile Thr Ala Thr Gln Val Ala Thr 
            340                 345                 350         

Tyr Arg Val Thr Ile Asn Tyr Glu Val Val Cys Leu Leu Ser Asp Arg 
        355                 360                 365             

Ile Pro Arg Glu Tyr Tyr 
    370                 

<210>   3503
<211>   360
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3503
atgatagttg gacacggaat tgacatcgaa gaattggctt cgatagaaag cgcagttaca   60
cgacatgaag gatttgctaa gcgtgtactg accgctcagg aaatggagcg cttcaccagt   120
ctcaaaggac gcaggcaaat agaatattta gctggtcgct ggtcggctaa ggaggccttt   180
tccaaggcta tgggaacggg cattagcaag ctcggttttc aggatttgga agtcttgaac   240
aatgaacgtg gggcgcctta ttttagtcag gcaccatttt caggaaagat ttggctgtct   300
atcagccaca ccgatcagtt tgtgacagcc agtgtcattt tggaggaaaa tcatgaaagc   360

<210>   3504
<211>   120
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   holo-(acyl-carrier protein) synthase (acpS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903584 (5.E-65)

<400>   3504
Met Ile Val Gly His Gly Ile Asp Ile Glu Glu Leu Ala Ser Ile Glu 
1               5                   10                  15      

Ser Ala Val Thr Arg His Glu Gly Phe Ala Lys Arg Val Leu Thr Ala 
            20                  25                  30          

Gln Glu Met Glu Arg Phe Thr Ser Leu Lys Gly Arg Arg Gln Ile Glu 
        35                  40                  45              

Tyr Leu Ala Gly Arg Trp Ser Ala Lys Glu Ala Phe Ser Lys Ala Met 
    50                  55                  60                  

Gly Thr Gly Ile Ser Lys Leu Gly Phe Gln Asp Leu Glu Val Leu Asn 
65                  70                  75                  80  

Asn Glu Arg Gly Ala Pro Tyr Phe Ser Gln Ala Pro Phe Ser Gly Lys 
                85                  90                  95      

Ile Trp Leu Ser Ile Ser His Thr Asp Gln Phe Val Thr Ala Ser Val 
            100                 105                 110         

Ile Leu Glu Glu Asn His Glu Ser 
        115                 120 

<210>   3505
<211>   1029
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3505
atggcattta ttgaaaaagg tcaagaaatc gatatggaag tcatcaaggc tgaaacccaa   60
ttgtctgcgg aagccttgag actcaaggaa agccgtgaca gggaattggc agatattatt   120
tcaggggaag atgaccgtat tctcttggtg attggtcctt gctcttctga taatgaagag   180
gcggtcttgg aatatgctcg ccgtttatct gccttgcaaa agaaggtagc ggataagatt   240
ttcatggtca tgcgcgtgta tactgctaag cctcgtacca atggagacgg ctataaagga   300
ttagttcacc agccagatac ttctaaggct ccaagcctga ttaatggctt gcaggctgtg   360
cgccagttgc actaccgcgt gattacagag actggtttga caacggcaga tgagatgctt   420
tatccgtcaa atctgatctt ggtggatgac ttggtcagct accatgccgt tggagctcgt   480
tctgtggaag accaagagca ccgctttgtg gcttctggga ttgatgcacc agtagggatg   540
aaaaatccaa cctcaggaaa tttgggtgtt atgtttaacg ccatctatgc tgctcaaaac   600
aagcaaacct tcctttatca tgggcaggaa gttgagacat caggtaatcc tttggcccat   660
gttatcctcc gtggagcagt caacgagtat ggcaattata tgccgaatta ctactatgaa   720
aatctactcc aagccattga acgctatgaa accatgggac ttgaaaatcc ttttatcctc   780
attgacacca accatgataa ctcaggcaag caatatatgg agcagattcg aattgttcgc   840
cagaccttgc agaatcgtga ttggaatgag aaaattaaaa agacggttcg aggatttatg   900
attgaatctt acctagcaga tggtcgtcaa aaccaaccag agatctttgg ttgctctatt   960
actgaccctt gcctaggttg ggaaaataca gaggccttgg tagaagagat ttatgttacc   1020
ttgacaaaa                                                           1029

<210>   3506
<211>   343
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phospho-2-dehydro-3-deoxyheptonate aldolase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903585 (0.E+01)

<400>   3506
Met Ala Phe Ile Glu Lys Gly Gln Glu Ile Asp Met Glu Val Ile Lys 
1               5                   10                  15      

Ala Glu Thr Gln Leu Ser Ala Glu Ala Leu Arg Leu Lys Glu Ser Arg 
            20                  25                  30          

Asp Arg Glu Leu Ala Asp Ile Ile Ser Gly Glu Asp Asp Arg Ile Leu 
        35                  40                  45              

Leu Val Ile Gly Pro Cys Ser Ser Asp Asn Glu Glu Ala Val Leu Glu 
    50                  55                  60                  

Tyr Ala Arg Arg Leu Ser Ala Leu Gln Lys Lys Val Ala Asp Lys Ile 
65                  70                  75                  80  

Phe Met Val Met Arg Val Tyr Thr Ala Lys Pro Arg Thr Asn Gly Asp 
                85                  90                  95      

Gly Tyr Lys Gly Leu Val His Gln Pro Asp Thr Ser Lys Ala Pro Ser 
            100                 105                 110         

Leu Ile Asn Gly Leu Gln Ala Val Arg Gln Leu His Tyr Arg Val Ile 
        115                 120                 125             

Thr Glu Thr Gly Leu Thr Thr Ala Asp Glu Met Leu Tyr Pro Ser Asn 
    130                 135                 140                 

Leu Ile Leu Val Asp Asp Leu Val Ser Tyr His Ala Val Gly Ala Arg 
145                 150                 155                 160 

Ser Val Glu Asp Gln Glu His Arg Phe Val Ala Ser Gly Ile Asp Ala 
                165                 170                 175     

Pro Val Gly Met Lys Asn Pro Thr Ser Gly Asn Leu Gly Val Met Phe 
            180                 185                 190         

Asn Ala Ile Tyr Ala Ala Gln Asn Lys Gln Thr Phe Leu Tyr His Gly 
        195                 200                 205             

Gln Glu Val Glu Thr Ser Gly Asn Pro Leu Ala His Val Ile Leu Arg 
    210                 215                 220                 

Gly Ala Val Asn Glu Tyr Gly Asn Tyr Met Pro Asn Tyr Tyr Tyr Glu 
225                 230                 235                 240 

Asn Leu Leu Gln Ala Ile Glu Arg Tyr Glu Thr Met Gly Leu Glu Asn 
                245                 250                 255     

Pro Phe Ile Leu Ile Asp Thr Asn His Asp Asn Ser Gly Lys Gln Tyr 
            260                 265                 270         

Met Glu Gln Ile Arg Ile Val Arg Gln Thr Leu Gln Asn Arg Asp Trp 
        275                 280                 285             

Asn Glu Lys Ile Lys Lys Thr Val Arg Gly Phe Met Ile Glu Ser Tyr 
    290                 295                 300                 

Leu Ala Asp Gly Arg Gln Asn Gln Pro Glu Ile Phe Gly Cys Ser Ile 
305                 310                 315                 320 

Thr Asp Pro Cys Leu Gly Trp Glu Asn Thr Glu Ala Leu Val Glu Glu 
                325                 330                 335     

Ile Tyr Val Thr Leu Thr Lys 
            340             

<210>   3507
<211>   1029
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3507
atggtattta cagcaaaaag ctctaaaata aatatagaag aagttcgtgc cttgtcaaaa   60
ttagaaggtc aggctttgga gaggaaatca cagcgagatc aagagctaga agccattata   120
cgtggagaag accagcgaat tctcttggta atcgggccat gctcatctga caacgaagaa   180
gctgtccttg aatacgctaa gcgtttggca gtcctacaag aagaagtggc agatcgtatc   240
tttatggtta tgcgtgttta tactgccaaa ccccgtacca acggagatgg ctataagggc   300
ttgattcacc agcctaacgc gacagaagcg cctagtctta tcaatggaat caaagccgtt   360
cgccatcttc actatcgtgt catcacagaa acagggatga caactgctga tgaaatgctt   420
tatcctgaaa accttccgct tgtagatgat ttgatttctt acatggcagt tggtgcccgt   480
tcagttgaag accagcaaca ccgctttgtg gcaagtgggg caggattttc tactggtttt   540
aaaaatccaa cctctggaaa tctcaatgtc atgtttaatg ggatttatgc tgctcaaaac   600
aaacaaagtt tccttttctt aggaaaagaa gtagaaacaa ctgggaaccc gctttcacac   660
gctattcttc gtggtgctct taatgagtat ggaaaaaata ttcccaacta ctattatgac   720
aatttaattg ataccattgc ccagtatgag aaaatgggct tggaaaatcc ttttatcatc   780
attgatacca atcatgacaa ttctggtaag cagtatattg aacagatccg aattgtccgc   840
cagaccttga ttaaccgtgc ttggaatgaa aaaattaagc agttcgttcg tggttttatg   900
attgagtctt atctggaaga tggtcgacaa aatgagccag aagtatttgg taagtctatc   960
acagaccctt gcctgggttg ggataacaca gaagctcttg tcagagaaat ttacaaaacg   1020
ttaggagaa                                                           1029

<210>   3508
<211>   343
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phospho-2-dehydro-3-deoxyheptonate aldolase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903586 (0.E+01)

<400>   3508
Met Val Phe Thr Ala Lys Ser Ser Lys Ile Asn Ile Glu Glu Val Arg 
1               5                   10                  15      

Ala Leu Ser Lys Leu Glu Gly Gln Ala Leu Glu Arg Lys Ser Gln Arg 
            20                  25                  30          

Asp Gln Glu Leu Glu Ala Ile Ile Arg Gly Glu Asp Gln Arg Ile Leu 
        35                  40                  45              

Leu Val Ile Gly Pro Cys Ser Ser Asp Asn Glu Glu Ala Val Leu Glu 
    50                  55                  60                  

Tyr Ala Lys Arg Leu Ala Val Leu Gln Glu Glu Val Ala Asp Arg Ile 
65                  70                  75                  80  

Phe Met Val Met Arg Val Tyr Thr Ala Lys Pro Arg Thr Asn Gly Asp 
                85                  90                  95      

Gly Tyr Lys Gly Leu Ile His Gln Pro Asn Ala Thr Glu Ala Pro Ser 
            100                 105                 110         

Leu Ile Asn Gly Ile Lys Ala Val Arg His Leu His Tyr Arg Val Ile 
        115                 120                 125             

Thr Glu Thr Gly Met Thr Thr Ala Asp Glu Met Leu Tyr Pro Glu Asn 
    130                 135                 140                 

Leu Pro Leu Val Asp Asp Leu Ile Ser Tyr Met Ala Val Gly Ala Arg 
145                 150                 155                 160 

Ser Val Glu Asp Gln Gln His Arg Phe Val Ala Ser Gly Ala Gly Phe 
                165                 170                 175     

Ser Thr Gly Phe Lys Asn Pro Thr Ser Gly Asn Leu Asn Val Met Phe 
            180                 185                 190         

Asn Gly Ile Tyr Ala Ala Gln Asn Lys Gln Ser Phe Leu Phe Leu Gly 
        195                 200                 205             

Lys Glu Val Glu Thr Thr Gly Asn Pro Leu Ser His Ala Ile Leu Arg 
    210                 215                 220                 

Gly Ala Leu Asn Glu Tyr Gly Lys Asn Ile Pro Asn Tyr Tyr Tyr Asp 
225                 230                 235                 240 

Asn Leu Ile Asp Thr Ile Ala Gln Tyr Glu Lys Met Gly Leu Glu Asn 
                245                 250                 255     

Pro Phe Ile Ile Ile Asp Thr Asn His Asp Asn Ser Gly Lys Gln Tyr 
            260                 265                 270         

Ile Glu Gln Ile Arg Ile Val Arg Gln Thr Leu Ile Asn Arg Ala Trp 
        275                 280                 285             

Asn Glu Lys Ile Lys Gln Phe Val Arg Gly Phe Met Ile Glu Ser Tyr 
    290                 295                 300                 

Leu Glu Asp Gly Arg Gln Asn Glu Pro Glu Val Phe Gly Lys Ser Ile 
305                 310                 315                 320 

Thr Asp Pro Cys Leu Gly Trp Asp Asn Thr Glu Ala Leu Val Arg Glu 
                325                 330                 335     

Ile Tyr Lys Thr Leu Gly Glu 
            340             

<210>   3509
<211>   2511
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3509
atggctaata ttttaaaaac aattatcgaa aatgataaag gagaaatccg tcgtctggaa   60
aagatggctg acaaggtttt caaatacgaa gaccaaatgg ctgctttgac tgacgaccaa   120
ctaaaagcaa aaacagttga atttaaggaa cgttatcaaa atggagaatc actggattca   180
ttgctttacg aagcatttgc ggttgtccgt gaaggtgcca aacgtgtcct aggtctcttc   240
ccttataagg ttcaggtcat gggggggatt gttcttcacc atggtgacgt gccagagatg   300
cgtacagggg aagggaaaac cttgactgcg accatgccgg tatacctcaa tgccctttca   360
ggtaaagggg ttcacgtagt tacggttaat gaatacctgt cagaacgtga cgcgactgag   420
atgggtgaat tgtactcttg gcttggtttg tcagtaggga ttaacttggc taccaaatct   480
ccaatggaga aaaaagaagc ctatgagtgt gatattactt actcaactaa ctcagaaatc   540
ggatttgact accttcgtga caacatggtc gttcgcgccg aaaacatggt acaacgtccg   600
cttaactatg ccttggtcga tgaggttgac tctatcttga ttgacgaggc tcgtacacct   660
ttgattgtat caggtgccaa tgcggttgaa accagtcagt tgtatcacat ggcagaccac   720
tatgtaaaat ctttgaacaa agatgactac atcatcgatg tgcagtctaa gactattggt   780
ttgtctgatt cagggattga cagggctgaa agctacttca aacttgaaaa cctctatgac   840
atcgaaaacg tggctttgac tcactttatc gataacgccc ttcgtgccaa ctacatcatg   900
cttctcgata ttgactatgt ggtgagcgaa gagcaagaaa tcttgattgt cgaccaattt   960
acaggtcgta ccatggaagg tcgtcgttat tctgatggat tgcaccaagc tattgaagcc   1020
aaagaaggtg tgccaatcca ggatgaaacc aagacatctg cctcaatcac gtaccaaaac   1080
ctcttccgta tgtacaagaa attgtctggt atgacgggta caggtaagac tgaggaagaa   1140
gaattccgtg aaatctacaa cattcgtgtt attccaatcc caacaaaccg tcctgttcaa   1200
cgtattgacc actcagacct tctttatgca agtatcgaat ctaagtttaa agcggttgtc   1260
gaagacgtta aggctcgtta ccaaaagggt caacctgtct tggttggtac agtagcggtt   1320
gaaactagtg actacatttc taagaaattg gttgcagctg gtgttcctca cgaagtcttg   1380
aatgccaaaa accactatag agaagcccaa atcatcatga atgctggtca acgtggtgcc   1440
gttaccatcg caaccaacat ggcgggtcgt ggtaccgaca tcaagcttgg tgaaggtgtt   1500
cgtgaacttg gaggactttg tgttattggt acagaacgtc atgaaagtcg tcgtatcgat   1560
aaccagcttc gtggacgttc aggtcgtcaa ggagatccag gtgagtcaca attctaccta   1620
tctcttgaag atgatttgat gaaacgtttt ggttctgaac gcttgaaggg aatctttgaa   1680
cgcttgaaca tgtctgaaga ggccattgag tctcgcatgt tgacgcgtca ggttgaagca   1740
gctcagaaac gtgtcgaagg aaataactac gatacccgta aacaagtcct tcaatacgat   1800
gatgtcatgc gtgaacaacg tgagattatc tatgctcaac gttacgatgt catcactgca   1860
gatcgtgact tggcacctga aattcagtct atgatcaaac gcacgattga acgtgtcgtt   1920
gatggtcatg cgcgtgccaa acaagatgaa aaactagagg caattttgaa ctttgctaag   1980
tacaacttgc ttcctgaaga ttctattacg atggaagact tgtcaggctt gtctgataag   2040
gccatcaagg aagagctttt ccaacgttcc ttgaaggttt acgatagtca ggtttcaaaa   2100
ctacgcgatg aagaagcagt taaagaattc caaaaagttt tgattctacg agtggtggat   2160
aacaagtgga cagatcatat cgatgccctt gatcaattgc gtaacgcggt tggacttcgt   2220
ggctatgctc agaacaaccc tgttgttgag tatcaggcag aaggtttccg tatgtttaat   2280
gatatgattg gttcgattga gtttgatgtg acacgcttga tgatgaaagc acaaattcat   2340
gaacaagaaa gaccacaggc agaacgtcat atcagtacaa cagcgactcg caatatcgct   2400
gctcaccaag caagtatgcc agaagatttg gatttgagcc agattggacg caatgaactt   2460
tgcccatgtg gttctggtaa gaaatttaaa aactgtcacg gtaaaagaca a            2511

<210>   3510
<211>   837
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   preprotein translocase, SecA subunit (secA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903587 (0.E+01)

<400>   3510
Met Ala Asn Ile Leu Lys Thr Ile Ile Glu Asn Asp Lys Gly Glu Ile 
1               5                   10                  15      

Arg Arg Leu Glu Lys Met Ala Asp Lys Val Phe Lys Tyr Glu Asp Gln 
            20                  25                  30          

Met Ala Ala Leu Thr Asp Asp Gln Leu Lys Ala Lys Thr Val Glu Phe 
        35                  40                  45              

Lys Glu Arg Tyr Gln Asn Gly Glu Ser Leu Asp Ser Leu Leu Tyr Glu 
    50                  55                  60                  

Ala Phe Ala Val Val Arg Glu Gly Ala Lys Arg Val Leu Gly Leu Phe 
65                  70                  75                  80  

Pro Tyr Lys Val Gln Val Met Gly Gly Ile Val Leu His His Gly Asp 
                85                  90                  95      

Val Pro Glu Met Arg Thr Gly Glu Gly Lys Thr Leu Thr Ala Thr Met 
            100                 105                 110         

Pro Val Tyr Leu Asn Ala Leu Ser Gly Lys Gly Val His Val Val Thr 
        115                 120                 125             

Val Asn Glu Tyr Leu Ser Glu Arg Asp Ala Thr Glu Met Gly Glu Leu 
    130                 135                 140                 

Tyr Ser Trp Leu Gly Leu Ser Val Gly Ile Asn Leu Ala Thr Lys Ser 
145                 150                 155                 160 

Pro Met Glu Lys Lys Glu Ala Tyr Glu Cys Asp Ile Thr Tyr Ser Thr 
                165                 170                 175     

Asn Ser Glu Ile Gly Phe Asp Tyr Leu Arg Asp Asn Met Val Val Arg 
            180                 185                 190         

Ala Glu Asn Met Val Gln Arg Pro Leu Asn Tyr Ala Leu Val Asp Glu 
        195                 200                 205             

Val Asp Ser Ile Leu Ile Asp Glu Ala Arg Thr Pro Leu Ile Val Ser 
    210                 215                 220                 

Gly Ala Asn Ala Val Glu Thr Ser Gln Leu Tyr His Met Ala Asp His 
225                 230                 235                 240 

Tyr Val Lys Ser Leu Asn Lys Asp Asp Tyr Ile Ile Asp Val Gln Ser 
                245                 250                 255     

Lys Thr Ile Gly Leu Ser Asp Ser Gly Ile Asp Arg Ala Glu Ser Tyr 
            260                 265                 270         

Phe Lys Leu Glu Asn Leu Tyr Asp Ile Glu Asn Val Ala Leu Thr His 
        275                 280                 285             

Phe Ile Asp Asn Ala Leu Arg Ala Asn Tyr Ile Met Leu Leu Asp Ile 
    290                 295                 300                 

Asp Tyr Val Val Ser Glu Glu Gln Glu Ile Leu Ile Val Asp Gln Phe 
305                 310                 315                 320 

Thr Gly Arg Thr Met Glu Gly Arg Arg Tyr Ser Asp Gly Leu His Gln 
                325                 330                 335     

Ala Ile Glu Ala Lys Glu Gly Val Pro Ile Gln Asp Glu Thr Lys Thr 
            340                 345                 350         

Ser Ala Ser Ile Thr Tyr Gln Asn Leu Phe Arg Met Tyr Lys Lys Leu 
        355                 360                 365             

Ser Gly Met Thr Gly Thr Gly Lys Thr Glu Glu Glu Glu Phe Arg Glu 
    370                 375                 380                 

Ile Tyr Asn Ile Arg Val Ile Pro Ile Pro Thr Asn Arg Pro Val Gln 
385                 390                 395                 400 

Arg Ile Asp His Ser Asp Leu Leu Tyr Ala Ser Ile Glu Ser Lys Phe 
                405                 410                 415     

Lys Ala Val Val Glu Asp Val Lys Ala Arg Tyr Gln Lys Gly Gln Pro 
            420                 425                 430         

Val Leu Val Gly Thr Val Ala Val Glu Thr Ser Asp Tyr Ile Ser Lys 
        435                 440                 445             

Lys Leu Val Ala Ala Gly Val Pro His Glu Val Leu Asn Ala Lys Asn 
    450                 455                 460                 

His Tyr Arg Glu Ala Gln Ile Ile Met Asn Ala Gly Gln Arg Gly Ala 
465                 470                 475                 480 

Val Thr Ile Ala Thr Asn Met Ala Gly Arg Gly Thr Asp Ile Lys Leu 
                485                 490                 495     

Gly Glu Gly Val Arg Glu Leu Gly Gly Leu Cys Val Ile Gly Thr Glu 
            500                 505                 510         

Arg His Glu Ser Arg Arg Ile Asp Asn Gln Leu Arg Gly Arg Ser Gly 
        515                 520                 525             

Arg Gln Gly Asp Pro Gly Glu Ser Gln Phe Tyr Leu Ser Leu Glu Asp 
    530                 535                 540                 

Asp Leu Met Lys Arg Phe Gly Ser Glu Arg Leu Lys Gly Ile Phe Glu 
545                 550                 555                 560 

Arg Leu Asn Met Ser Glu Glu Ala Ile Glu Ser Arg Met Leu Thr Arg 
                565                 570                 575     

Gln Val Glu Ala Ala Gln Lys Arg Val Glu Gly Asn Asn Tyr Asp Thr 
            580                 585                 590         

Arg Lys Gln Val Leu Gln Tyr Asp Asp Val Met Arg Glu Gln Arg Glu 
        595                 600                 605             

Ile Ile Tyr Ala Gln Arg Tyr Asp Val Ile Thr Ala Asp Arg Asp Leu 
    610                 615                 620                 

Ala Pro Glu Ile Gln Ser Met Ile Lys Arg Thr Ile Glu Arg Val Val 
625                 630                 635                 640 

Asp Gly His Ala Arg Ala Lys Gln Asp Glu Lys Leu Glu Ala Ile Leu 
                645                 650                 655     

Asn Phe Ala Lys Tyr Asn Leu Leu Pro Glu Asp Ser Ile Thr Met Glu 
            660                 665                 670         

Asp Leu Ser Gly Leu Ser Asp Lys Ala Ile Lys Glu Glu Leu Phe Gln 
        675                 680                 685             

Arg Ser Leu Lys Val Tyr Asp Ser Gln Val Ser Lys Leu Arg Asp Glu 
    690                 695                 700                 

Glu Ala Val Lys Glu Phe Gln Lys Val Leu Ile Leu Arg Val Val Asp 
705                 710                 715                 720 

Asn Lys Trp Thr Asp His Ile Asp Ala Leu Asp Gln Leu Arg Asn Ala 
                725                 730                 735     

Val Gly Leu Arg Gly Tyr Ala Gln Asn Asn Pro Val Val Glu Tyr Gln 
            740                 745                 750         

Ala Glu Gly Phe Arg Met Phe Asn Asp Met Ile Gly Ser Ile Glu Phe 
        755                 760                 765             

Asp Val Thr Arg Leu Met Met Lys Ala Gln Ile His Glu Gln Glu Arg 
    770                 775                 780                 

Pro Gln Ala Glu Arg His Ile Ser Thr Thr Ala Thr Arg Asn Ile Ala 
785                 790                 795                 800 

Ala His Gln Ala Ser Met Pro Glu Asp Leu Asp Leu Ser Gln Ile Gly 
                805                 810                 815     

Arg Asn Glu Leu Cys Pro Cys Gly Ser Gly Lys Lys Phe Lys Asn Cys 
            820                 825                 830         

His Gly Lys Arg Gln 
        835         

<210>   3511
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3511
atggcacatc taaaatcatt tattacacga tattccaagg tttatattgg tttagttctg   60
ctgatctggc tgtctttctt ctttatccct tgggataaac cacttctggg gataaggatt   120
gacatcttca tcatacagaa aatcttgcta gcttttggaa ttctgtccat tctcatggcc   180
ttgctgtcca agaaagtcag tctctttgtt tttggactga tttgctgtct ttctctttgg   240
attaacttat ttatcacatt tgccattttg ccgatttttg gcaat                   285

<210>   3512
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903588 (8.E-25)

<400>   3512
Met Ala His Leu Lys Ser Phe Ile Thr Arg Tyr Ser Lys Val Tyr Ile 
1               5                   10                  15      

Gly Leu Val Leu Leu Ile Trp Leu Ser Phe Phe Phe Ile Pro Trp Asp 
            20                  25                  30          

Lys Pro Leu Leu Gly Ile Arg Ile Asp Ile Phe Ile Ile Gln Lys Ile 
        35                  40                  45              

Leu Leu Ala Phe Gly Ile Leu Ser Ile Leu Met Ala Leu Leu Ser Lys 
    50                  55                  60                  

Lys Val Ser Leu Phe Val Phe Gly Leu Ile Cys Cys Leu Ser Leu Trp 
65                  70                  75                  80  

Ile Asn Leu Phe Ile Thr Phe Ala Ile Leu Pro Ile Phe Gly Asn 
                85                  90                  95  

<210>   3513
<211>   630
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3513
atgagacttg aaattataaa tggacagaaa atttatggga aaagacctat tttaaatcag   60
ttgaatttgg tgtttcaatc aggaaaaatt tatggactta aaggtgataa tggatctggc   120
aagacggttc ttttaaagat acttgctggt tatattaagc ttgacaaagg aaaagttctt   180
caagatggta aagtttacgg ggtaaaaaat cattatattc aggatgcagg aattttaatt   240
gaaaaagtcg agtttttatc tcatttatcc ctgagagaaa atttggaact gttaaggtat   300
ttttcatcta aagttacgga aaaaagaatt gcctattgga ttcaatacta tgatttacag   360
gaatttgaag acattgaata ccgtcattta tccttaggaa caaagcaaaa aatggccttg   420
attcaagcct ttatttcctc tccttctata ctctttctcg atgaacctat gaatgctttg   480
gatgagaaga gtgtgaggtt aaccaaacag gtcattttat cttacctgaa aaaagaaaat   540
ggtctggtta tcctgacgtc gcacatatcg gaagatattt cagacctttg tacagatgta   600
ttagttgtcg aaaatggaca tatacaaatg                                    630

<210>   3514
<211>   210
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903589 (e-115)

<400>   3514
Met Arg Leu Glu Ile Ile Asn Gly Gln Lys Ile Tyr Gly Lys Arg Pro 
1               5                   10                  15      

Ile Leu Asn Gln Leu Asn Leu Val Phe Gln Ser Gly Lys Ile Tyr Gly 
            20                  25                  30          

Leu Lys Gly Asp Asn Gly Ser Gly Lys Thr Val Leu Leu Lys Ile Leu 
        35                  40                  45              

Ala Gly Tyr Ile Lys Leu Asp Lys Gly Lys Val Leu Gln Asp Gly Lys 
    50                  55                  60                  

Val Tyr Gly Val Lys Asn His Tyr Ile Gln Asp Ala Gly Ile Leu Ile 
65                  70                  75                  80  

Glu Lys Val Glu Phe Leu Ser His Leu Ser Leu Arg Glu Asn Leu Glu 
                85                  90                  95      

Leu Leu Arg Tyr Phe Ser Ser Lys Val Thr Glu Lys Arg Ile Ala Tyr 
            100                 105                 110         

Trp Ile Gln Tyr Tyr Asp Leu Gln Glu Phe Glu Asp Ile Glu Tyr Arg 
        115                 120                 125             

His Leu Ser Leu Gly Thr Lys Gln Lys Met Ala Leu Ile Gln Ala Phe 
    130                 135                 140                 

Ile Ser Ser Pro Ser Ile Leu Phe Leu Asp Glu Pro Met Asn Ala Leu 
145                 150                 155                 160 

Asp Glu Lys Ser Val Arg Leu Thr Lys Gln Val Ile Leu Ser Tyr Leu 
                165                 170                 175     

Lys Lys Glu Asn Gly Leu Val Ile Leu Thr Ser His Ile Ser Glu Asp 
            180                 185                 190         

Ile Ser Asp Leu Cys Thr Asp Val Leu Val Val Glu Asn Gly His Ile 
        195                 200                 205             

Gln Met 
    210 


<210>   3515
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3515
atgtttaaga attttaacaa tattttgcta aatagaaaga ttgttttact acttcgtata   60
gttctgatga tgattttgat aaaccatcta ttgtcaacag cggttcaaaa gcaggatgct   120
gttatctttt tcaagagaga attgatttca attttttcct ataatgacta ttctgaagcg   180
aatttagaaa tccccaaact attgttaaac ctttcgcttt tcatggtagg atggctctct   240
gtcattttac ttgaaagtga tttggcagac cattaccatc acttgattcg ctatcaatca   300
agctcctttt tcgattatac aaggaaacga ttggttgtca tttctaaatt ttttactcaa   360
gatttgtttg tctggtttct tggtttactt cctctaggaa ttcatttcaa aacagtcgca   420
cttttctttt tacttgctca gttaatgatg ttgtacttac tactgtctta tctgatagca   480
ctgattagtg cgggcgctgg tttttccttt tttctctatt ttttagcatt tgtgggacaa   540
gaatggatga tggatcatat tgtaacagtg tatttagtac tcttaagttt attagttatg   600
ttgattgtta gtcgcttgga agagaaattt aagaaagga                          639

<210>   3516
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903590 (e-114)

<400>   3516
Met Phe Lys Asn Phe Asn Asn Ile Leu Leu Asn Arg Lys Ile Val Leu 
1               5                   10                  15      

Leu Leu Arg Ile Val Leu Met Met Ile Leu Ile Asn His Leu Leu Ser 
            20                  25                  30          

Thr Ala Val Gln Lys Gln Asp Ala Val Ile Phe Phe Lys Arg Glu Leu 
        35                  40                  45              

Ile Ser Ile Phe Ser Tyr Asn Asp Tyr Ser Glu Ala Asn Leu Glu Ile 
    50                  55                  60                  

Pro Lys Leu Leu Leu Asn Leu Ser Leu Phe Met Val Gly Trp Leu Ser 
65                  70                  75                  80  

Val Ile Leu Leu Glu Ser Asp Leu Ala Asp His Tyr His His Leu Ile 
                85                  90                  95      

Arg Tyr Gln Ser Ser Ser Phe Phe Asp Tyr Thr Arg Lys Arg Leu Val 
            100                 105                 110         

Val Ile Ser Lys Phe Phe Thr Gln Asp Leu Phe Val Trp Phe Leu Gly 
        115                 120                 125             

Leu Leu Pro Leu Gly Ile His Phe Lys Thr Val Ala Leu Phe Phe Leu 
    130                 135                 140                 

Leu Ala Gln Leu Met Met Leu Tyr Leu Leu Leu Ser Tyr Leu Ile Ala 
145                 150                 155                 160 

Leu Ile Ser Ala Gly Ala Gly Phe Ser Phe Phe Leu Tyr Phe Leu Ala 
                165                 170                 175     

Phe Val Gly Gln Glu Trp Met Met Asp His Ile Val Thr Val Tyr Leu 
            180                 185                 190         

Val Leu Leu Ser Leu Leu Val Met Leu Ile Val Ser Arg Leu Glu Glu 
        195                 200                 205             

Lys Phe Lys Lys Gly 
    210             

<210>   3517
<211>   828
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3517
ttgagtatta tattactttc tatttgtagg aggtggctta tgaagattcc tctcttaact   60
tttgcaaggc ataaatttgt ttatgtcttg cttactttgc tttttcttgc tttggtttat   120
cgtgatgttt tgatgactta tttctttttt gatattcatg cgcccgatct agctaaattc   180
gatggacaag caattaaaaa tgacttatta aaatcagcat tagattttcg tattctccag   240
ttcaatctag gtttttatca atcatttatt attccaatca tcattgtttt gctaggtttt   300
caatatattg agctgaaaaa taaagtttta cgattgagta ttggaagaga agtgagttat   360
caagggttaa aaagaaagtt gactttgcaa gttgcaagta tcccttgttt gatatattta   420
gtgactgtgc tgataattgc aattataacc tatttctttg ggactttttc tcctcttgga   480
tggaattctc tattttctga tggaagtggt ttacaaagac tcctagatgg agagataaaa   540
agctatttgt tctttacttg tgtcctacta atcggtattt tcatcaatgc aatctatttt   600
ttacaaatag ttgattatgt ggggaatgtg actcgttcgg caatcaccta tttgatgttt   660
ctttggcttg gttctatgct gctttatagt gccttgcctt actatatggt tcctatgacg   720
agtttgatgc aagctagcta tggggatgta agtttgatga aactctttac tccttatatc   780
ctttatattg tcccttacat ggtgcttgaa aaatatgaag ataatgtt                828

<210>   3518
<211>   276
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903591 (e-148)

<400>   3518
Met Ser Ile Ile Leu Leu Ser Ile Cys Arg Arg Trp Leu Met Lys Ile 
1               5                   10                  15      

Pro Leu Leu Thr Phe Ala Arg His Lys Phe Val Tyr Val Leu Leu Thr 
            20                  25                  30          

Leu Leu Phe Leu Ala Leu Val Tyr Arg Asp Val Leu Met Thr Tyr Phe 
        35                  40                  45              

Phe Phe Asp Ile His Ala Pro Asp Leu Ala Lys Phe Asp Gly Gln Ala 
    50                  55                  60                  

Ile Lys Asn Asp Leu Leu Lys Ser Ala Leu Asp Phe Arg Ile Leu Gln 
65                  70                  75                  80  

Phe Asn Leu Gly Phe Tyr Gln Ser Phe Ile Ile Pro Ile Ile Ile Val 
                85                  90                  95      

Leu Leu Gly Phe Gln Tyr Ile Glu Leu Lys Asn Lys Val Leu Arg Leu 
            100                 105                 110         

Ser Ile Gly Arg Glu Val Ser Tyr Gln Gly Leu Lys Arg Lys Leu Thr 
        115                 120                 125             

Leu Gln Val Ala Ser Ile Pro Cys Leu Ile Tyr Leu Val Thr Val Leu 
    130                 135                 140                 

Ile Ile Ala Ile Ile Thr Tyr Phe Phe Gly Thr Phe Ser Pro Leu Gly 
145                 150                 155                 160 

Trp Asn Ser Leu Phe Ser Asp Gly Ser Gly Leu Gln Arg Leu Leu Asp 
                165                 170                 175     

Gly Glu Ile Lys Ser Tyr Leu Phe Phe Thr Cys Val Leu Leu Ile Gly 
            180                 185                 190         

Ile Phe Ile Asn Ala Ile Tyr Phe Leu Gln Ile Val Asp Tyr Val Gly 
        195                 200                 205             

Asn Val Thr Arg Ser Ala Ile Thr Tyr Leu Met Phe Leu Trp Leu Gly 
    210                 215                 220                 

Ser Met Leu Leu Tyr Ser Ala Leu Pro Tyr Tyr Met Val Pro Met Thr 
225                 230                 235                 240 

Ser Leu Met Gln Ala Ser Tyr Gly Asp Val Ser Leu Met Lys Leu Phe 
                245                 250                 255     

Thr Pro Tyr Ile Leu Tyr Ile Val Pro Tyr Met Val Leu Glu Lys Tyr 
            260                 265                 270         

Glu Asp Asn Val 
        275     

<210>   3519
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3519
gtgatggaac acttgtttaa aatgataatc ttattaccct gtttttactt tttcagctgg   60
attgacaagg ataatagaga aagtaaattt ttcccaattt tttactattt ttactggatt   120
tacatcaccc tctatgctct ttttagcctt gcttggacag ttttttcagt tctgtttttc   180
aatatcgtct tgagaaattt gacagatatc aagttatggg gtatttggct attattacta   240
cttatcgctt ttgctagtga ctggttagcc tatgtctttt tcaaaaaaat gcttgacttg   300
agacgggaac tagggaagtc taaaggcgga aggcat                             336

<210>   3520

<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903594 (9.E-58)

<400>   3520
Met Met Glu His Leu Phe Lys Met Ile Ile Leu Leu Pro Cys Phe Tyr 
1               5                   10                  15      

Phe Phe Ser Trp Ile Asp Lys Asp Asn Arg Glu Ser Lys Phe Phe Pro 
            20                  25                  30          

Ile Phe Tyr Tyr Phe Tyr Trp Ile Tyr Ile Thr Leu Tyr Ala Leu Phe 
        35                  40                  45              

Ser Leu Ala Trp Thr Val Phe Ser Val Leu Phe Phe Asn Ile Val Leu 
    50                  55                  60                  

Arg Asn Leu Thr Asp Ile Lys Leu Trp Gly Ile Trp Leu Leu Leu Leu 
65                  70                  75                  80  

Leu Ile Ala Phe Ala Ser Asp Trp Leu Ala Tyr Val Phe Phe Lys Lys 
                85                  90                  95      

Met Leu Asp Leu Arg Arg Glu Leu Gly Lys Ser Lys Gly Gly Arg His 
            100                 105                 110         


<210>   3521
<211>   342
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3521
atgtcggtga tggaacattt gtttaaattc ttacttttag caccgtactt ttattttgat   60
aactggattg aaaaggccaa cagaaatagt aagttttttc caatttttta ttatttttac   120
tggttttaca tccccttcta ttctcttttt agccttgctt ggacagttgt ttcagttctg   180
tttttcaata ccgtcttgag aaatgtgaca gatatcaagt tatggggcat ttggtttctt   240
tttattctgc tagctattgg tatgaattgg ttaacttatt cctgtttcaa agaaatgttt   300
cgcttgagac aggaactagg gaagtctaag ggtggaaggc at                      342

<210>   3522
<211>   114
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903595 (2.E-67)

<400>   3522
Met Ser Val Met Glu His Leu Phe Lys Phe Leu Leu Leu Ala Pro Tyr 
1               5                   10                  15      

Phe Tyr Phe Asp Asn Trp Ile Glu Lys Ala Asn Arg Asn Ser Lys Phe 
            20                  25                  30          

Phe Pro Ile Phe Tyr Tyr Phe Tyr Trp Phe Tyr Ile Pro Phe Tyr Ser 
        35                  40                  45              

Leu Phe Ser Leu Ala Trp Thr Val Val Ser Val Leu Phe Phe Asn Thr 
    50                  55                  60                  

Val Leu Arg Asn Val Thr Asp Ile Lys Leu Trp Gly Ile Trp Phe Leu 
65                  70                  75                  80  

Phe Ile Leu Leu Ala Ile Gly Met Asn Trp Leu Thr Tyr Ser Cys Phe 
                85                  90                  95      

Lys Glu Met Phe Arg Leu Arg Gln Glu Leu Gly Lys Ser Lys Gly Gly 
            100                 105                 110         

Arg His 
        

<210>   3523
<211>   1308
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3523
atggccctac caactattgc cattgtagga cgtcccaatg ttgggaaatc aaccctattt   60
aatcggatcg ctggtgagcg aatctccatt gtagaagatg tcgaaggagt gacacgtgac   120
cgtatttatg caacgggtga gtggctcaat cgttctttta gcatgattga tacaggagga   180
attgatgatg tcgatgctcc tttcatggaa caaatcaagc accaggcaga aattgccatg   240
gaagaagcag atgttatcgt ttttgtcgtg tctggtaagg aaggaattac tgatgcagac   300
gaatacgtag ctcgtaagct ttataagacc cacaaaccag ttatcctcgc agtcaacaag   360
gtggacaacc ctgagatgag aaatgatata tatgatttct atgctctcgg tttgggtgaa   420
ccattgccta tctcatctgt ccatggaatc ggtacagggg atgtgctaga tgcgatcgta   480
gaaaatcttc caaatgaata tgaggaagaa aatccagatg tcattaagtt tagcttgatt   540
ggtcgtccta acgttggaaa atcaagcttg atcaatgcta tcttgggaga agaccgtgtt   600
attgctagtc ctgttgctgg aacaactcgt gatgccattg atacccactt tacagataca   660
gatggtcaag agtttaccat gattgatacg gctggtatgc gtaagtctgg taaggtttat   720
gaaaatactg agaaatactc tgttatgcgt gccatgcgtg ctattgaccg ttcagatgtg   780
gtcttgatgg tcatcaatgc ggaagaaggc attcgtgagt acgacaagcg tatcgcagga   840
tttgcccatg aagctggtaa agggatgatt atcgtggtca acaagtggga tacgcttgaa   900
aaagataacc acactatgaa aaactgggaa gaagatatcc gtgagcagtt ccaatacctg   960
ccttacgcac cgattatctt tgtatcagct ttaaccaagc aacgtctcca caaacttcct   1020
gagatgatta agcaaatcag cgaaagtcaa aatacacgta ttccatcagc tgtcttgaac   1080
gatgtcatca tggatgccat tgccatcaac ccaacaccga cagacaaagg aaaacgtctc   1140
aagattttct atgcgaccca agtggcaacc aaaccaccaa cctttgtcat ctttgtcaat   1200
gaagaagaac tcatgcactt ttcttacctg cgtttcttgg aaaatcaaat ccgcaaggcc   1260
tttgtttttg agggaacacc gattcatctc atcgcaagaa aacgcaaa                1308

<210>   3524
<211>   436
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoglycerate dehydrogenase-related protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903596 (0.E+01)

<400>   3524
Met Ala Leu Pro Thr Ile Ala Ile Val Gly Arg Pro Asn Val Gly Lys 
1               5                   10                  15      

Ser Thr Leu Phe Asn Arg Ile Ala Gly Glu Arg Ile Ser Ile Val Glu 
            20                  25                  30          

Asp Val Glu Gly Val Thr Arg Asp Arg Ile Tyr Ala Thr Gly Glu Trp 
        35                  40                  45              

Leu Asn Arg Ser Phe Ser Met Ile Asp Thr Gly Gly Ile Asp Asp Val 
    50                  55                  60                  

Asp Ala Pro Phe Met Glu Gln Ile Lys His Gln Ala Glu Ile Ala Met 
65                  70                  75                  80  

Glu Glu Ala Asp Val Ile Val Phe Val Val Ser Gly Lys Glu Gly Ile 
                85                  90                  95      

Thr Asp Ala Asp Glu Tyr Val Ala Arg Lys Leu Tyr Lys Thr His Lys 
            100                 105                 110         

Pro Val Ile Leu Ala Val Asn Lys Val Asp Asn Pro Glu Met Arg Asn 
        115                 120                 125             

Asp Ile Tyr Asp Phe Tyr Ala Leu Gly Leu Gly Glu Pro Leu Pro Ile 
    130                 135                 140                 

Ser Ser Val His Gly Ile Gly Thr Gly Asp Val Leu Asp Ala Ile Val 
145                 150                 155                 160 

Glu Asn Leu Pro Asn Glu Tyr Glu Glu Glu Asn Pro Asp Val Ile Lys 
                165                 170                 175     

Phe Ser Leu Ile Gly Arg Pro Asn Val Gly Lys Ser Ser Leu Ile Asn 
            180                 185                 190         

Ala Ile Leu Gly Glu Asp Arg Val Ile Ala Ser Pro Val Ala Gly Thr 
        195                 200                 205             

Thr Arg Asp Ala Ile Asp Thr His Phe Thr Asp Thr Asp Gly Gln Glu 
    210                 215                 220                 

Phe Thr Met Ile Asp Thr Ala Gly Met Arg Lys Ser Gly Lys Val Tyr 
225                 230                 235                 240 

Glu Asn Thr Glu Lys Tyr Ser Val Met Arg Ala Met Arg Ala Ile Asp 
                245                 250                 255     

Arg Ser Asp Val Val Leu Met Val Ile Asn Ala Glu Glu Gly Ile Arg 
            260                 265                 270         

Glu Tyr Asp Lys Arg Ile Ala Gly Phe Ala His Glu Ala Gly Lys Gly 
        275                 280                 285             

Met Ile Ile Val Val Asn Lys Trp Asp Thr Leu Glu Lys Asp Asn His 
    290                 295                 300                 

Thr Met Lys Asn Trp Glu Glu Asp Ile Arg Glu Gln Phe Gln Tyr Leu 
305                 310                 315                 320 

Pro Tyr Ala Pro Ile Ile Phe Val Ser Ala Leu Thr Lys Gln Arg Leu 
                325                 330                 335     

His Lys Leu Pro Glu Met Ile Lys Gln Ile Ser Glu Ser Gln Asn Thr 
            340                 345                 350         

Arg Ile Pro Ser Ala Val Leu Asn Asp Val Ile Met Asp Ala Ile Ala 
        355                 360                 365             

Ile Asn Pro Thr Pro Thr Asp Lys Gly Lys Arg Leu Lys Ile Phe Tyr 

    370                 375                 380                 

Ala Thr Gln Val Ala Thr Lys Pro Pro Thr Phe Val Ile Phe Val Asn 
385                 390                 395                 400 

Glu Glu Glu Leu Met His Phe Ser Tyr Leu Arg Phe Leu Glu Asn Gln 
                405                 410                 415     

Ile Arg Lys Ala Phe Val Phe Glu Gly Thr Pro Ile His Leu Ile Ala 
            420                 425                 430         

Arg Lys Arg Lys 
        435     

<210>   3525
<211>   711
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3525
atgacagaaa ccattaaatt gatgaaggct catacttcag tgcgcaggtt taaagagcaa   60
gaaattcccc aagtagactt aaatgagatt ttgacagcag cccagatggc atcatcttgg   120
aagaatttcc aatcctactc tgtgattgtg gtacgaagtc aagagaagaa agatgccttg   180
tatgaattgg tacctcaaga agccattcgc cagtctgctg ttttccttct ctttgtcgga   240
gatttgaacc gagcagaaaa gggagcccga cttcataccg acaccttcca accccaaggt   300
gtggaaggtc tcttgattag ttcggtcgat gcagctcttg ctggacaaaa cgccttgttg   360
gcagctgaaa gcttgggcta tggtggtgtg attatcggtt tggttcgata caagtctgaa   420
gaagtggcag agctctttaa cctacctgac tacacctatt ctgtctttgg gatggcactg   480
ggtgtgccaa atcaacatca tgatatgaaa ccgagactgc cactagagaa tgttgtcttt   540
gaggaagaat accaagaaca gtcaactgag gcaatccaag cttatgaccg tgttcaggct   600
gactatgctg gggcgcgtgc gaccacaagc tggagtcagc gcctagcaga acagtttggt   660
caagctgaac caagctcaac tagaaaaaat cttgaacaga agaaattatt g            711

<210>   3526
<211>   237
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   nitroreductase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903597 (e-129)

<400>   3526
Met Thr Glu Thr Ile Lys Leu Met Lys Ala His Thr Ser Val Arg Arg 
1               5                   10                  15      

Phe Lys Glu Gln Glu Ile Pro Gln Val Asp Leu Asn Glu Ile Leu Thr 
            20                  25                  30          

Ala Ala Gln Met Ala Ser Ser Trp Lys Asn Phe Gln Ser Tyr Ser Val 
        35                  40                  45              

Ile Val Val Arg Ser Gln Glu Lys Lys Asp Ala Leu Tyr Glu Leu Val 
    50                  55                  60                  

Pro Gln Glu Ala Ile Arg Gln Ser Ala Val Phe Leu Leu Phe Val Gly 
65                  70                  75                  80  

Asp Leu Asn Arg Ala Glu Lys Gly Ala Arg Leu His Thr Asp Thr Phe 
                85                  90                  95      

Gln Pro Gln Gly Val Glu Gly Leu Leu Ile Ser Ser Val Asp Ala Ala 
            100                 105                 110         

Leu Ala Gly Gln Asn Ala Leu Leu Ala Ala Glu Ser Leu Gly Tyr Gly 
        115                 120                 125             

Gly Val Ile Ile Gly Leu Val Arg Tyr Lys Ser Glu Glu Val Ala Glu 
    130                 135                 140                 

Leu Phe Asn Leu Pro Asp Tyr Thr Tyr Ser Val Phe Gly Met Ala Leu 
145                 150                 155                 160 

Gly Val Pro Asn Gln His His Asp Met Lys Pro Arg Leu Pro Leu Glu 
                165                 170                 175     

Asn Val Val Phe Glu Glu Glu Tyr Gln Glu Gln Ser Thr Glu Ala Ile 
            180                 185                 190         

Gln Ala Tyr Asp Arg Val Gln Ala Asp Tyr Ala Gly Ala Arg Ala Thr 
        195                 200                 205             

Thr Ser Trp Ser Gln Arg Leu Ala Glu Gln Phe Gly Gln Ala Glu Pro 
    210                 215                 220                 

Ser Ser Thr Arg Lys Asn Leu Glu Gln Lys Lys Leu Leu 
225                 230                 235         

<210>   3527
<211>   894
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3527
atggaaagtg tcggagacgt actcaaacgt caacccagcc gtttttatta tcaagatttg   60
gtccagaaaa tcatgaagga ccctgatgtt gcggccttta tccagcaaga atccttaact   120
ccaaaggaat taaatcgcag tatctccaag tttaatcagt acatcaccga gcgtgacaag   180
tttctccgtg gggatacgga ttatattgcc aaaggctaca agccgatttt ggttaagaat   240
catggttatg cagatgtttc atatgaagaa actcctgagc taatcgcggc tgaaaaagaa   300
gcggctatta agaaccgtct caagttaatc aatctaccag ccagtctcaa gaaagctagt   360
ttggctcaag ttgacttgga tgatttgggg cgcttaccag tttttgaaaa gctactagcc   420
ttcgtggagc aatatccagc tattcgaaaa ggtctttact tatatggaga ctttggtgtg   480
ggtaaaagtt tcatggtggc ggccttagct catgatttat cagaaaaacg tggtgtttca   540
tcaactctcc tccactatcc tagctttgtc attgatgtca aaaatgctat cagtgatggc   600
aatgttaaga ccttggtgga tgagattaag ctgtctgagg tcctgatttt agatgatatt   660
ggcgccgagc aatcaaccgt ttgggtgcgt gacgaaatcc tgcaggtcat tctccaatat   720
cggatgcagg aaaatttacc gacctttttc acatccaact tcaactttga agatttggag   780
aagcattttg cgaaagtgaa acatggaaat gacgaaacct gggaagccag acgggtcatg   840
gaacgcatcc gttatttggc tgaggagact cgtttagaag gagtaaaccg tcga         894

<210>   3528
<211>   298
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   primosomal protein DnaI (dnaI)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903598 (e-151)

<400>   3528
Met Glu Ser Val Gly Asp Val Leu Lys Arg Gln Pro Ser Arg Phe Tyr 
1               5                   10                  15      

Tyr Gln Asp Leu Val Gln Lys Ile Met Lys Asp Pro Asp Val Ala Ala 
            20                  25                  30          

Phe Ile Gln Gln Glu Ser Leu Thr Pro Lys Glu Leu Asn Arg Ser Ile 
        35                  40                  45              

Ser Lys Phe Asn Gln Tyr Ile Thr Glu Arg Asp Lys Phe Leu Arg Gly 
    50                  55                  60                  

Asp Thr Asp Tyr Ile Ala Lys Gly Tyr Lys Pro Ile Leu Val Lys Asn 
65                  70                  75                  80  

His Gly Tyr Ala Asp Val Ser Tyr Glu Glu Thr Pro Glu Leu Ile Ala 
                85                  90                  95      

Ala Glu Lys Glu Ala Ala Ile Lys Asn Arg Leu Lys Leu Ile Asn Leu 
            100                 105                 110         

Pro Ala Ser Leu Lys Lys Ala Ser Leu Ala Gln Val Asp Leu Asp Asp 
        115                 120                 125             

Leu Gly Arg Leu Pro Val Phe Glu Lys Leu Leu Ala Phe Val Glu Gln 
    130                 135                 140                 

Tyr Pro Ala Ile Arg Lys Gly Leu Tyr Leu Tyr Gly Asp Phe Gly Val 
145                 150                 155                 160 

Gly Lys Ser Phe Met Val Ala Ala Leu Ala His Asp Leu Ser Glu Lys 
                165                 170                 175     

Arg Gly Val Ser Ser Thr Leu Leu His Tyr Pro Ser Phe Val Ile Asp 
            180                 185                 190         

Val Lys Asn Ala Ile Ser Asp Gly Asn Val Lys Thr Leu Val Asp Glu 
        195                 200                 205             

Ile Lys Leu Ser Glu Val Leu Ile Leu Asp Asp Ile Gly Ala Glu Gln 
    210                 215                 220                 

Ser Thr Val Trp Val Arg Asp Glu Ile Leu Gln Val Ile Leu Gln Tyr 
225                 230                 235                 240 

Arg Met Gln Glu Asn Leu Pro Thr Phe Phe Thr Ser Asn Phe Asn Phe 
                245                 250                 255     

Glu Asp Leu Glu Lys His Phe Ala Lys Val Lys His Gly Asn Asp Glu 
            260                 265                 270         

Thr Trp Glu Ala Arg Arg Val Met Glu Arg Ile Arg Tyr Leu Ala Glu 
        275                 280                 285             

Glu Thr Arg Leu Glu Gly Val Asn Arg Arg 
    290                 295             

<210>   3529
<211>   1167
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3529
atgaagccaa ttgaccgttt ttcttatcta aagaataatc gggtgtcgca agatacctca   60
tctctggtac agtgctacct cccgattatc ggtcaggagg cactgagcct ttatctttat   120
acaatcagtt tttgggataa tggtagaaag gaatatcttt tttcaagcat tctcaaccat   180
ctcaactttg ggatggatag actgataaaa tcattgaaaa tcttatctgc ttttaatctc   240
ttgaccctct atcaaaaggg tgatgtttat cagctagccc tccatgctcc tctatctagt   300
caagacttct tggggcatcc tgtttatcgc agactcttag agaaaaagat tggcgatgta   360
gctgtggagg atttgaaagt tgaaagtgct gatggtgaag aaatacctgt ctcactcaat   420
caagtctttc cagaattggc agaactaggc agtcaagaag accttggtct caagaagaaa   480
gtggccaatg attttgactt ggaacatttt cgccagctga tggctcgaga tggacttcgt   540
tttgcggatg agcagtccga tgtcttaaac ctctttgcta ttgccgagga gaagaaatgg   600
acttggtttg aaacctatca attggccaag tcaacagctg tttcccaggt tatttcaacc   660
aaacgcatgc gtgaaaaaat tgctcaaaaa ccagtttcct ctgactttag tcttaaggaa   720
gcgaccatta tcaaagaagc taaaagtaaa actgccctgc agttcttagc agaaatcaag   780
caaacacgca agggaaccat tacccaaaca gaaagagaac tcttgcaaca gatggctggc   840
ttgggcttac tggacgaagt catcaatatt attctcttat tgacctttaa taaggtggat   900
tcggcaaata tcaatgagaa atatgccatg aaggtagcca atgactatgc ctatcaaaag   960
attcattcgg cagaagaggc cgttttacga attcgtgatc gagggcagaa agcaaaaaca   1020
caaaaacaga atcagactgc cccagaaaaa accaatgttc ctaaatggag taatcctgaa   1080
tataagaatg aaaccagcga ggaaactcgt ctggaactag aacgtaagaa gcaagaacta   1140
ttagctcgat tagaaaaagg aggagat                                       1167

<210>   3530
<211>   389
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Chromosome replication)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903599 (0.E+01)

<400>   3530
Met Lys Pro Ile Asp Arg Phe Ser Tyr Leu Lys Asn Asn Arg Val Ser 
1               5                   10                  15      

Gln Asp Thr Ser Ser Leu Val Gln Cys Tyr Leu Pro Ile Ile Gly Gln 
            20                  25                  30          

Glu Ala Leu Ser Leu Tyr Leu Tyr Thr Ile Ser Phe Trp Asp Asn Gly 
        35                  40                  45              

Arg Lys Glu Tyr Leu Phe Ser Ser Ile Leu Asn His Leu Asn Phe Gly 
    50                  55                  60                  

Met Asp Arg Leu Ile Lys Ser Leu Lys Ile Leu Ser Ala Phe Asn Leu 
65                  70                  75                  80  

Leu Thr Leu Tyr Gln Lys Gly Asp Val Tyr Gln Leu Ala Leu His Ala 
                85                  90                  95      

Pro Leu Ser Ser Gln Asp Phe Leu Gly His Pro Val Tyr Arg Arg Leu 
            100                 105                 110         

Leu Glu Lys Lys Ile Gly Asp Val Ala Val Glu Asp Leu Lys Val Glu 
        115                 120                 125             

Ser Ala Asp Gly Glu Glu Ile Pro Val Ser Leu Asn Gln Val Phe Pro 
    130                 135                 140                 

Glu Leu Ala Glu Leu Gly Ser Gln Glu Asp Leu Gly Leu Lys Lys Lys 
145                 150                 155                 160 

Val Ala Asn Asp Phe Asp Leu Glu His Phe Arg Gln Leu Met Ala Arg 
                165                 170                 175     

Asp Gly Leu Arg Phe Ala Asp Glu Gln Ser Asp Val Leu Asn Leu Phe 
            180                 185                 190         

Ala Ile Ala Glu Glu Lys Lys Trp Thr Trp Phe Glu Thr Tyr Gln Leu 
        195                 200                 205             

Ala Lys Ser Thr Ala Val Ser Gln Val Ile Ser Thr Lys Arg Met Arg 
    210                 215                 220                 

Glu Lys Ile Ala Gln Lys Pro Val Ser Ser Asp Phe Ser Leu Lys Glu 
225                 230                 235                 240 

Ala Thr Ile Ile Lys Glu Ala Lys Ser Lys Thr Ala Leu Gln Phe Leu 
                245                 250                 255     

Ala Glu Ile Lys Gln Thr Arg Lys Gly Thr Ile Thr Gln Thr Glu Arg 
            260                 265                 270         

Glu Leu Leu Gln Gln Met Ala Gly Leu Gly Leu Leu Asp Glu Val Ile 
        275                 280                 285             

Asn Ile Ile Leu Leu Leu Thr Phe Asn Lys Val Asp Ser Ala Asn Ile 
    290                 295                 300                 

Asn Glu Lys Tyr Ala Met Lys Val Ala Asn Asp Tyr Ala Tyr Gln Lys 
305                 310                 315                 320 

Ile His Ser Ala Glu Glu Ala Val Leu Arg Ile Arg Asp Arg Gly Gln 
                325                 330                 335     

Lys Ala Lys Thr Gln Lys Gln Asn Gln Thr Ala Pro Glu Lys Thr Asn 
            340                 345                 350         

Val Pro Lys Trp Ser Asn Pro Glu Tyr Lys Asn Glu Thr Ser Glu Glu 
        355                 360                 365             

Thr Arg Leu Glu Leu Glu Arg Lys Lys Gln Glu Leu Leu Ala Arg Leu 
    370                 375                 380                 

Glu Lys Gly Gly Asp 
385                 

<210>   3531
<211>   471
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3531
atgcgttgtc caaaatgtgg ggctaccaag tcaagtgtta tcgatagtcg ccaagcagaa   60
gaagggaaca ccattcgtag aagacgtgag tgcgacgaat gccaacaccg ttttacaacc   120
tacgaacgag tagaagaaag aaccttagtg gttgttaaaa aagatggcac acgggaacaa   180
ttctccagag ataaaatctt taatgggatt atccgctcag cccagaaacg tcctgtgtca   240
agtgatgaaa tcaacatggt agtcaatcgt atcgaacaga aactccgtgg tcgaaatgaa   300
aatgaaattc aaagtgagga cattggttca ctcgtcatgg aggagttggc tgaattggac   360
gagattacct atgtacgttt tgctagtgtc tatcgtagtt ttaaggatgt cagtgagtta   420
gagagcttgc tccaacaaat cacccagtcc tctaaaaaga aaaaggaaag a            471

<210>   3532
<211>   157
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903600 (1.E-85)

<400>   3532
Met Arg Cys Pro Lys Cys Gly Ala Thr Lys Ser Ser Val Ile Asp Ser 
1               5                   10                  15      

Arg Gln Ala Glu Glu Gly Asn Thr Ile Arg Arg Arg Arg Glu Cys Asp 
            20                  25                  30          

Glu Cys Gln His Arg Phe Thr Thr Tyr Glu Arg Val Glu Glu Arg Thr 
        35                  40                  45              

Leu Val Val Val Lys Lys Asp Gly Thr Arg Glu Gln Phe Ser Arg Asp 
    50                  55                  60                  

Lys Ile Phe Asn Gly Ile Ile Arg Ser Ala Gln Lys Arg Pro Val Ser 
65                  70                  75                  80  

Ser Asp Glu Ile Asn Met Val Val Asn Arg Ile Glu Gln Lys Leu Arg 
                85                  90                  95      

Gly Arg Asn Glu Asn Glu Ile Gln Ser Glu Asp Ile Gly Ser Leu Val 
            100                 105                 110         

Met Glu Glu Leu Ala Glu Leu Asp Glu Ile Thr Tyr Val Arg Phe Ala 
        115                 120                 125             

Ser Val Tyr Arg Ser Phe Lys Asp Val Ser Glu Leu Glu Ser Leu Leu 
    130                 135                 140                 

Gln Gln Ile Thr Gln Ser Ser Lys Lys Lys Lys Glu Arg 
145                 150                 155         

<210>   3533
<211>   363
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3533
atgtcctgga catttgacaa caaaaaaccc atctatttac agattatgga gaaaatcaag   60
cttcagattg tttcccatac actggaaccc aatcaacaac ttccaaccgt gagggagcta   120
gctagcgagg ctggtgtcaa tcccaatacc atccaaagag ccttatcaga ccttgaacga   180
gaaggatttg tctacagcaa gcgaacaact ggacgatttg tgactaagga taaggagcta   240
atcgcccagt cacgcaaaca attatcagaa gaagaattgg aacacttcgt ttcctccatg   300
acccattttg gctatgaaaa agaagaacta ccaggcgtag tcagtgatta tattaaagga   360
gtt                                                                 363

<210>   3534
<211>   121
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, GntR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903601 (6.E-66)

<400>   3534
Met Ser Trp Thr Phe Asp Asn Lys Lys Pro Ile Tyr Leu Gln Ile Met 
1               5                   10                  15      

Glu Lys Ile Lys Leu Gln Ile Val Ser His Thr Leu Glu Pro Asn Gln 
            20                  25                  30          

Gln Leu Pro Thr Val Arg Glu Leu Ala Ser Glu Ala Gly Val Asn Pro 
        35                  40                  45              

Asn Thr Ile Gln Arg Ala Leu Ser Asp Leu Glu Arg Glu Gly Phe Val 
    50                  55                  60                  

Tyr Ser Lys Arg Thr Thr Gly Arg Phe Val Thr Lys Asp Lys Glu Leu 
65                  70                  75                  80  

Ile Ala Gln Ser Arg Lys Gln Leu Ser Glu Glu Glu Leu Glu His Phe 
                85                  90                  95      

Val Ser Ser Met Thr His Phe Gly Tyr Glu Lys Glu Glu Leu Pro Gly 
            100                 105                 110         

Val Val Ser Asp Tyr Ile Lys Gly Val 
        115                 120     

<210>   3535
<211>   1503
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3535
gtgattatat taaaggagtt taagcctatg tcattactag tatttgaaaa tgtatccaaa   60
tcatatggag caacaccagc ccttgaaaat gtttctcttg acattccagc tggaaaaatt   120
gtcggccttc ttgggccaaa cggctcagga aaaacaaccc tgattaaact aattaatggc   180
ctcttacaac cagatcaagg acgtgtcctc atcaacgaca tggacccaag cccagcaacc   240
aaggccgttg tagcttattt gcctgatacg acctatctca atgagcaaat gaaggtcaaa   300
gaagccctaa cctacttcaa gaccttctat aaagatttca atcttgaacg cgcccatcat   360
ctacttgcag acctgggcat tgatgaaaat agtcgtctca agaaactatc aaaagaaaac   420
aaagaaaagg ttcaactgat tttggttatg agccgtgatg ctcgtctcta tgttttggac   480
gaacccattg gtggggtgga tccagcagcc cgtgcttata tcctcaatac cattatcaac   540
aactactcac caacttctac cgttttgatt tctacccact tgatttctga tatcgagcca   600
atcttggatg aaattgtctt cctaaaagac ggaaaagtcg tccgtcaagg aaatgtagat   660
gatattcgct acgagtcagg tgaatccatt gaccaactct tccgtcagaa tttaaggcct   720
aagcaaagga gattatttat gttttggaat ttagttcgct acgaatttaa aaatgttaac   780
aagtggtatt tagccctcta cgcagccgtg ctagtccttt ctgccctcat cggaatacag   840
acacaaggct ttaaaaatct accttaccaa gaaagtcagg ctactatgct actttttcta   900
gctacagtct ttggtggctt gatgcttaca cttgggattt caaccatttt cttgattatt   960
aaacgcttca aaggtagtgt ctacgaccga caaggctatc tgactttgac cttgccagtt   1020
tctgaacacc atatcatcac agccaaacta atcggtgcct ttatctggtc attgattagc   1080
accgctgtat tggctctaag tgctgttatt attctggctt taacagctcc agaatggatt   1140
cctctttctt atgtgattac atttgtagaa acacatctcc ctcagatctt tcttacaggt   1200
atatccttcc tactaaatac tatttcagga atcctctgca tctacctggc tatttccatt   1260
ggacagcttt tcaatgaata ccgtacagca ctcgctgttg cagtctacat tggtatccaa   1320
atcgtcattg gatttattga acttttcttc aatcttagtt ctaatttcta tgtcaattca   1380
ctggtaggac tcaatgacca tttctatatg ggagcaggta tagccattgt tgaagaactc   1440
atattcatag ctatctttta tctcggaacc tactacatct tgagaaataa ggttaatttg   1500
ctt                                                                 1503

<210>   3536
<211>   501
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903603 (e-147)

<400>   3536
Met Ile Ile Leu Lys Glu Phe Lys Pro Met Ser Leu Leu Val Phe Glu 
1               5                   10                  15      

Asn Val Ser Lys Ser Tyr Gly Ala Thr Pro Ala Leu Glu Asn Val Ser 
            20                  25                  30          

Leu Asp Ile Pro Ala Gly Lys Ile Val Gly Leu Leu Gly Pro Asn Gly 
        35                  40                  45              

Ser Gly Lys Thr Thr Leu Ile Lys Leu Ile Asn Gly Leu Leu Gln Pro 
    50                  55                  60                  

Asp Gln Gly Arg Val Leu Ile Asn Asp Met Asp Pro Ser Pro Ala Thr 
65                  70                  75                  80  

Lys Ala Val Val Ala Tyr Leu Pro Asp Thr Thr Tyr Leu Asn Glu Gln 
                85                  90                  95      

Met Lys Val Lys Glu Ala Leu Thr Tyr Phe Lys Thr Phe Tyr Lys Asp 
            100                 105                 110         

Phe Asn Leu Glu Arg Ala His His Leu Leu Ala Asp Leu Gly Ile Asp 
        115                 120                 125             

Glu Asn Ser Arg Leu Lys Lys Leu Ser Lys Glu Asn Lys Glu Lys Val 
    130                 135                 140                 

Gln Leu Ile Leu Val Met Ser Arg Asp Ala Arg Leu Tyr Val Leu Asp 
145                 150                 155                 160 

Glu Pro Ile Gly Gly Val Asp Pro Ala Ala Arg Ala Tyr Ile Leu Asn 
                165                 170                 175     

Thr Ile Ile Asn Asn Tyr Ser Pro Thr Ser Thr Val Leu Ile Ser Thr 
            180                 185                 190         

His Leu Ile Ser Asp Ile Glu Pro Ile Leu Asp Glu Ile Val Phe Leu 
        195                 200                 205             

Lys Asp Gly Lys Val Val Arg Gln Gly Asn Val Asp Asp Ile Arg Tyr 
    210                 215                 220                 

Glu Ser Gly Glu Ser Ile Asp Gln Leu Phe Arg Gln Asn Leu Arg Pro 
225                 230                 235                 240 

Lys Gln Arg Arg Leu Phe Met Phe Trp Asn Leu Val Arg Tyr Glu Phe 
                245                 250                 255     

Lys Asn Val Asn Lys Trp Tyr Leu Ala Leu Tyr Ala Ala Val Leu Val 
            260                 265                 270         

Leu Ser Ala Leu Ile Gly Ile Gln Thr Gln Gly Phe Lys Asn Leu Pro 
        275                 280                 285             

Tyr Gln Glu Ser Gln Ala Thr Met Leu Leu Phe Leu Ala Thr Val Phe 
    290                 295                 300                 

Gly Gly Leu Met Leu Thr Leu Gly Ile Ser Thr Ile Phe Leu Ile Ile 
305                 310                 315                 320 

Lys Arg Phe Lys Gly Ser Val Tyr Asp Arg Gln Gly Tyr Leu Thr Leu 
                325                 330                 335     

Thr Leu Pro Val Ser Glu His His Ile Ile Thr Ala Lys Leu Ile Gly 
            340                 345                 350         

Ala Phe Ile Trp Ser Leu Ile Ser Thr Ala Val Leu Ala Leu Ser Ala 
        355                 360                 365             

Val Ile Ile Leu Ala Leu Thr Ala Pro Glu Trp Ile Pro Leu Ser Tyr 
    370                 375                 380                 

Val Ile Thr Phe Val Glu Thr His Leu Pro Gln Ile Phe Leu Thr Gly 
385                 390                 395                 400 

Ile Ser Phe Leu Leu Asn Thr Ile Ser Gly Ile Leu Cys Ile Tyr Leu 
                405                 410                 415     

Ala Ile Ser Ile Gly Gln Leu Phe Asn Glu Tyr Arg Thr Ala Leu Ala 
            420                 425                 430         

Val Ala Val Tyr Ile Gly Ile Gln Ile Val Ile Gly Phe Ile Glu Leu 
        435                 440                 445             

Phe Phe Asn Leu Ser Ser Asn Phe Tyr Val Asn Ser Leu Val Gly Leu 
    450                 455                 460                 

Asn Asp His Phe Tyr Met Gly Ala Gly Ile Ala Ile Val Glu Glu Leu 
465                 470                 475                 480 

Ile Phe Ile Ala Ile Phe Tyr Leu Gly Thr Tyr Tyr Ile Leu Arg Asn 
                485                 490                 495     

Lys Val Asn Leu Leu 
            500     

<210>   3537
<211>   1197
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3537
atgagaaata tgtgggttgt aatcaaggaa acctatcttc gacatgtcga gtcatggagt   60
ttcttcttta tggtgatttc gccgttcctc tttttaggaa tctctgtagg aattgggcat   120
ctccaaggtt cttctatggc taaaaataat aaagtggcag tagtgacaac agtgccatct   180
gtagcagaag gactgaagaa tgtaaatggt gttaacttcg actataaaga cgaagcaagt   240
gccaaagaag caattaaaga agaaaaatta aaaggttatt tgaccattga tcaagaagat   300
agtgttctaa aggcagttta tcatggcgaa acatcgcttg aaaatggaat taaatttgag   360
gttacaggta cactcaatga actgcaaaat cagcttaatc gttcaactgc ttccttgtct   420
caagagcagg aaaaacgctt agcgcagaca attcaattca cagaaaagat tgatgaagcc   480
aaggaaaata aaaagtttat tcaaacaatt gcagcaggtg ccttaggatt ctttctttat   540
atgattctga ttacctatgc gggtgtaaca gctcaggaag ttgccagtga aaaaggcacc   600
aaaattatgg aagtcgtttt ttctagcata agggcaagtc actatttcta tgcgcggatg   660
atggctctgt ttctagtgat tttaacgcat attgggatct atgttgtagg tggtctggct   720
gccgttttgc tctttaaaga tttgccattc ttggctcagt ctggtatttt ggatcacttg   780
ggagatgcta tctcactgaa taccttgctc tttattttga tcagtctttt catgtacgta   840
gtcttggcag ccttcctagg atctatggtt tctcgtcctg aggactcagg gaaagccttg   900
tcgcctttga tgattttgat tatgggtggt ttttttggag tgacagctct aggtgcagct   960
ggtgacaatc tcctcttgaa gattggttct tatattccct ttatttcgac cttctttatg   1020
ccgtttcgaa cgattaatga ctatgcgggg ggagcagaag catggatttc acttgctatt   1080
acagtgattt ttgcggtggt agcaacagga tttatcggac gcatgtatgc tagtctcgtt   1140
cttcaaacgg atgatttagg gatttggaaa acctttaaac gtgccttatc ttataaa      1197

<210>   3538
<211>   399
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (ABC transporter)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903604 (0.E+01)

<400>   3538
Met Arg Asn Met Trp Val Val Ile Lys Glu Thr Tyr Leu Arg His Val 
1               5                   10                  15      

Glu Ser Trp Ser Phe Phe Phe Met Val Ile Ser Pro Phe Leu Phe Leu 
            20                  25                  30          

Gly Ile Ser Val Gly Ile Gly His Leu Gln Gly Ser Ser Met Ala Lys 
        35                  40                  45              

Asn Asn Lys Val Ala Val Val Thr Thr Val Pro Ser Val Ala Glu Gly 
    50                  55                  60                  

Leu Lys Asn Val Asn Gly Val Asn Phe Asp Tyr Lys Asp Glu Ala Ser 
65                  70                  75                  80  

Ala Lys Glu Ala Ile Lys Glu Glu Lys Leu Lys Gly Tyr Leu Thr Ile 
                85                  90                  95      

Asp Gln Glu Asp Ser Val Leu Lys Ala Val Tyr His Gly Glu Thr Ser 
            100                 105                 110         

Leu Glu Asn Gly Ile Lys Phe Glu Val Thr Gly Thr Leu Asn Glu Leu 
        115                 120                 125             

Gln Asn Gln Leu Asn Arg Ser Thr Ala Ser Leu Ser Gln Glu Gln Glu 
    130                 135                 140                 

Lys Arg Leu Ala Gln Thr Ile Gln Phe Thr Glu Lys Ile Asp Glu Ala 
145                 150                 155                 160 

Lys Glu Asn Lys Lys Phe Ile Gln Thr Ile Ala Ala Gly Ala Leu Gly 
                165                 170                 175     

Phe Phe Leu Tyr Met Ile Leu Ile Thr Tyr Ala Gly Val Thr Ala Gln 
            180                 185                 190         

Glu Val Ala Ser Glu Lys Gly Thr Lys Ile Met Glu Val Val Phe Ser 
        195                 200                 205             

Ser Ile Arg Ala Ser His Tyr Phe Tyr Ala Arg Met Met Ala Leu Phe 

    210                 215                 220                 

Leu Val Ile Leu Thr His Ile Gly Ile Tyr Val Val Gly Gly Leu Ala 
225                 230                 235                 240 

Ala Val Leu Leu Phe Lys Asp Leu Pro Phe Leu Ala Gln Ser Gly Ile 
                245                 250                 255     

Leu Asp His Leu Gly Asp Ala Ile Ser Leu Asn Thr Leu Leu Phe Ile 
            260                 265                 270         

Leu Ile Ser Leu Phe Met Tyr Val Val Leu Ala Ala Phe Leu Gly Ser 
        275                 280                 285             

Met Val Ser Arg Pro Glu Asp Ser Gly Lys Ala Leu Ser Pro Leu Met 
    290                 295                 300                 

Ile Leu Ile Met Gly Gly Phe Phe Gly Val Thr Ala Leu Gly Ala Ala 
305                 310                 315                 320 

Gly Asp Asn Leu Leu Leu Lys Ile Gly Ser Tyr Ile Pro Phe Ile Ser 
                325                 330                 335     

Thr Phe Phe Met Pro Phe Arg Thr Ile Asn Asp Tyr Ala Gly Gly Ala 
            340                 345                 350         

Glu Ala Trp Ile Ser Leu Ala Ile Thr Val Ile Phe Ala Val Val Ala 
        355                 360                 365             

Thr Gly Phe Ile Gly Arg Met Tyr Ala Ser Leu Val Leu Gln Thr Asp 
    370                 375                 380                 

Asp Leu Gly Ile Trp Lys Thr Phe Lys Arg Ala Leu Ser Tyr Lys 
385                 390                 395                 

<210>   3539
<211>   890
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3539
atgctagaag taagaagtct agagaaaagt tttggatcca agcaagtttt gtttggtatt   60
gactttcaag cgcgaccagg tcgtattttg ggactagtcg gaaaaaatgg tgctggaaaa   120
acaacgattt tccatagtat tttgaaattc ctagaatatc agggagaaat cggtctggat   180
ggtcaggata ttcgtcagga gacctatgct cggattggtt atctgcctga agaacgcatc   240
tcatgcctaa attgacagtt cttgaacaag ttcgctactt ggcgactcta aaaggcatgg   300
atgccaaaga agtcaaagaa aaactccctc aatggatgaa gaggttggaa gtgaaaggaa   360
agctgacaga taaaatcaag agtctgtcaa aaggaaatca gcagaagatt cagctcatta   420
ttactctgat tcatgaacca gacctgatta tcttggatga gccttttagt ggattggacc   480
cagttaatac agaattgctc aaacaagtca tttttcagga aaaagagcgc ggagcaacca   540
ttatcttttc tgaccatgtc atgaccaatg ttgaggaact ttgtgacgat attctgatga   600
tccgagatgg ccgtgtggtc ttgcacggac cagttcagga tgtccgcaat caatacggga   660
aaacgcgtct ctttgtttca agtgaacgaa gcaaggaaga attggaaaat cttcctcatg   720
tcaaacaggt gagcttgacc aaacaaggca gttggaaatt gattttggag gatgagagcg   780
ctggaaggga actcttctca atcttgactc aaggtcaata tatcgcaaca tttgaccaac   840
aagcgccaac tatcgatgaa atctttaaac tagaatcagg agtggaagta              890


<210>   3540
<400>   3540
000

<210>   3541
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3541
ttgattttca ttgagtataa aagtgctcca ggccatattt tacacagcaa tagtcttcta   60
aaaatggaca aaaaacattg taaaggctat caaaaaggag ta                      102

<210>   3542

<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3542
Met Ile Phe Ile Glu Tyr Lys Ser Ala Pro Gly His Ile Leu His Ser 
1               5                   10                  15      

Asn Ser Leu Leu Lys Met Asp Lys Lys His Cys Lys Gly Tyr Gln Lys 
            20                  25                  30          

Gly Val 
        

<210>   3543
<211>   189
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3543
atgaaaatca aagagcaaac taggaagcta gccgtagact gctcaaagta cagctttgag   60
gttgcagata aaactgacga agtcgactca aaacactgtt ttgaggttgt ggatagaact   120
gacgaagtcg ataactatat ctacggcaag gcgaagctga cgtggtttga agagattttc   180
gaagagtat                                                           189

<210>   3544
<211>   63
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3544
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Val Asp Cys Ser Lys 
1               5                   10                  15      

Tyr Ser Phe Glu Val Ala Asp Lys Thr Asp Glu Val Asp Ser Lys His 
            20                  25                  30          

Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Asp Asn Tyr Ile Tyr 
        35                  40                  45              

Gly Lys Ala Lys Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr 
    50                  55                  60              

<210>   3545
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3545
atgaacttgt ttcttataaa aatgttgtct gaaactatta gcctttttcc agaagtttta   60
gaggaagaaa actttacgag gaaaaaggag ttactcaaa                          99

<210>   3546
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (ABC transporter)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903605 (e-166)

<400>   3546
Met Asn Leu Phe Leu Ile Lys Met Leu Ser Glu Thr Ile Ser Leu Phe 
1               5                   10                  15      

Pro Glu Val Leu Glu Glu Glu Asn Phe Thr Arg Lys Lys Glu Leu Leu 
            20                  25                  30          

Lys 
    

<210>   3547
<211>   615
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3547
atgtcacagg ataaacaaat gaaagctgtt tctccccttc tgcagcgagt tatcaatatc   60
tcatcgattg tcggtggggt tgggagtttg attttctgta tttgggctta tcaggctggg   120
attttacaat ccaaggaaac cctctctgcc tttatccagc aggcaggcat ctggggtcca   180
cctctcttta tctttttaca gattttacag actgtcgtcc ctatcattcc aggggccttg   240
acctcggtgg ctggggtctt tatctacggg cacatcatcg ggactatcta caactatatc   300
ggcatcgtga ttggctgtgc cattatcttt tatctagtgc gcctatacgg agctgccttt   360
gtccagtctg tcgtcagcaa gcgcacctac gacaagtaca tcgactggct agataagggc   420
aatcgttttg accgcttctt tatttttatg atgatttggc ccattagccc agctgacttt   480
ctctgtatgc tggctgccct gaccaagatg agcttcaagc gctacatgac catcatcatt   540

ctgaccaaac cctttaccct cgtggtttat acctacggtc tgacctatat tattgacttt   600
ttctggcaaa tgctt                                                    615

<210>   3548
<211>   205
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903607 (e-116)

<400>   3548
Met Ser Gln Asp Lys Gln Met Lys Ala Val Ser Pro Leu Leu Gln Arg 
1               5                   10                  15      

Val Ile Asn Ile Ser Ser Ile Val Gly Gly Val Gly Ser Leu Ile Phe 
            20                  25                  30          

Cys Ile Trp Ala Tyr Gln Ala Gly Ile Leu Gln Ser Lys Glu Thr Leu 
        35                  40                  45              

Ser Ala Phe Ile Gln Gln Ala Gly Ile Trp Gly Pro Pro Leu Phe Ile 
    50                  55                  60                  

Phe Leu Gln Ile Leu Gln Thr Val Val Pro Ile Ile Pro Gly Ala Leu 
65                  70                  75                  80  

Thr Ser Val Ala Gly Val Phe Ile Tyr Gly His Ile Ile Gly Thr Ile 
                85                  90                  95      

Tyr Asn Tyr Ile Gly Ile Val Ile Gly Cys Ala Ile Ile Phe Tyr Leu 
            100                 105                 110         

Val Arg Leu Tyr Gly Ala Ala Phe Val Gln Ser Val Val Ser Lys Arg 
        115                 120                 125             

Thr Tyr Asp Lys Tyr Ile Asp Trp Leu Asp Lys Gly Asn Arg Phe Asp 
    130                 135                 140                 

Arg Phe Phe Ile Phe Met Met Ile Trp Pro Ile Ser Pro Ala Asp Phe 
145                 150                 155                 160 

Leu Cys Met Leu Ala Ala Leu Thr Lys Met Ser Phe Lys Arg Tyr Met 
                165                 170                 175     

Thr Ile Ile Ile Leu Thr Lys Pro Phe Thr Leu Val Val Tyr Thr Tyr 
            180                 185                 190         

Gly Leu Thr Tyr Ile Ile Asp Phe Phe Trp Gln Met Leu 
        195                 200                 205 

<210>   3549
<211>   885
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3549
atgacaaaat tatatggaag cttggaagcg ggcggtacaa agtttgtctg tgctgtcggt   60
gatgaaaact ttaacgttgt agaaaaaaca caatttccaa caacaactcc aatcgaaaca   120
atcgataaaa ccattgagtt cttctcaaaa ttcgataacc ttgctggtct tgcagttggt   180
tcatttgggc cgattgatat tgacaaaaac tcaaaaactt atggctttat cacgacgact   240
ccaaaaccaa actgggcaaa tgtagacttg cttggtgccc ttcgtcgcgc cctaaacgtg   300
ccaatgtact tcacaacaga cgtaaacagc tctgcttacg gtgaaatggt tgcccgtaac   360
aatgctggtg gtcgtatcga aaacttggtt tactacacaa tcggtacagg tatcggtgca   420
ggcgtcatcc aacgtggtga gtttatcggt ggtgtgggtc accctgaaat gggtcattat   480
tatgttgcta gacacccaat ggatattgaa aaagagttta agggtgtttg tcctttccat   540
aagggatgtc tagaaggtta tgcagctggt ccaagtttgg aagctcgtac aggtgtacgt   600
ggggaaacta ttgaactcaa caaccctgtt tgggatgttc aagcctacta tatcgctcaa   660
gctgcggtta atgcgacagt gactttccgc ccagacgtga ttgtctttgg tggaggggtc   720
atggctcaac aacatatgct ggaccgtgtc cgtgagaaat ttacatctct tcttaatggt   780
tacctaccag taccagatgt gcgtgactat atcgtgacgc cagcagtcgc aggaaatggt   840
tctgccacac ttgggaactt tgttcttgca aaagaagttt caaaa                   885

<210>   3550
<211>   295
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fructokinase (scrK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903608 (e-173)

<400>   3550
Met Thr Lys Leu Tyr Gly Ser Leu Glu Ala Gly Gly Thr Lys Phe Val 
1               5                   10                  15      

Cys Ala Val Gly Asp Glu Asn Phe Asn Val Val Glu Lys Thr Gln Phe 
            20                  25                  30          

Pro Thr Thr Thr Pro Ile Glu Thr Ile Asp Lys Thr Ile Glu Phe Phe 
        35                  40                  45              

Ser Lys Phe Asp Asn Leu Ala Gly Leu Ala Val Gly Ser Phe Gly Pro 
    50                  55                  60                  

Ile Asp Ile Asp Lys Asn Ser Lys Thr Tyr Gly Phe Ile Thr Thr Thr 
65                  70                  75                  80  

Pro Lys Pro Asn Trp Ala Asn Val Asp Leu Leu Gly Ala Leu Arg Arg 
                85                  90                  95      

Ala Leu Asn Val Pro Met Tyr Phe Thr Thr Asp Val Asn Ser Ser Ala 
            100                 105                 110         

Tyr Gly Glu Met Val Ala Arg Asn Asn Ala Gly Gly Arg Ile Glu Asn 
        115                 120                 125             

Leu Val Tyr Tyr Thr Ile Gly Thr Gly Ile Gly Ala Gly Val Ile Gln 
    130                 135                 140                 

Arg Gly Glu Phe Ile Gly Gly Val Gly His Pro Glu Met Gly His Tyr 
145                 150                 155                 160 

Tyr Val Ala Arg His Pro Met Asp Ile Glu Lys Glu Phe Lys Gly Val 
                165                 170                 175     

Cys Pro Phe His Lys Gly Cys Leu Glu Gly Tyr Ala Ala Gly Pro Ser 
            180                 185                 190         

Leu Glu Ala Arg Thr Gly Val Arg Gly Glu Thr Ile Glu Leu Asn Asn 
        195                 200                 205             

Pro Val Trp Asp Val Gln Ala Tyr Tyr Ile Ala Gln Ala Ala Val Asn 
    210                 215                 220                 

Ala Thr Val Thr Phe Arg Pro Asp Val Ile Val Phe Gly Gly Gly Val 
225                 230                 235                 240 

Met Ala Gln Gln His Met Leu Asp Arg Val Arg Glu Lys Phe Thr Ser 
                245                 250                 255     

Leu Leu Asn Gly Tyr Leu Pro Val Pro Asp Val Arg Asp Tyr Ile Val 
            260                 265                 270         

Thr Pro Ala Val Ala Gly Asn Gly Ser Ala Thr Leu Gly Asn Phe Val 
        275                 280                 285             

Leu Ala Lys Glu Val Ser Lys 
    290                 295 

<210>   3551
<211>   1002
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3551
ttgattggtg gggttcacca attgatcgtc gtgtcaggtg tgcaccacat cttcaacttg   60
cttgaagtgc aattacttgc tgctgaccat gctaacccat tcaacgctat catcacagct   120
gctatgacag ctcaaggtgc tgctactgtt gcggttggtg ttaaaacaaa aaatccaaaa   180
ctgaaaacac ttgctttccc ggctgctctt tctgccttcc taggtattac agagcctgct   240
atcttcgggg tgaacttgcg cttccgtaaa ccattcttcc tttcattgat tgctggtgca   300
atcggtggtg gattggcttc tatccttgga cttgctggta ctggtaatgg tatcaccatc   360
atccctggta caatgcttta tgttggtaac ggacaacttc cacaatacct tcttatggta   420
gctgtatcat ttgcccttgg ttttgctctt acttacatgt ttggttacga agatgaagta   480
gacgcaactg cagctgcaaa acgagctgaa gtggctgaag aaaaagaaga agttgcgcca   540
gcagctcttc aaaatgaaac acttgtaact cctatcgtcg gtgatgttgt cgctcttgct   600
gatgtcaatg acccagtctt ctcaagtgga gctatgggac aaggtatcgt tgtgaaacca   660
agccaaggcg tggtctatgc accagctgat gctgaagttt caattgcctt tccaacaggg   720
cacgcttttg gtttgaaaac aagaaatggt gctgaagttt tgattcatgt tggtattgat   780
actgtatcta tgaacggtga cggttttgaa acaaaagttg ctcaaggtaa taaggtgaaa   840
gctggcgatg ttcttggaac atttgactca aacaaaatcg ctgcagctgg acttgatgat   900
acaacaatgg ttatcgttac aaatacaggt gactacgctt cagtagctcc agtcgcaaca   960
ggttcagttg ctaaggggga tgctgtgatc gaagtgaaaa tc                      1002

<210>   3552
<211>   334
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIAC components
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903609 (0.E+01)

<400>   3552
Met Ile Gly Gly Val His Gln Leu Ile Val Val Ser Gly Val His His 
1               5                   10                  15      

Ile Phe Asn Leu Leu Glu Val Gln Leu Leu Ala Ala Asp His Ala Asn 
            20                  25                  30          

Pro Phe Asn Ala Ile Ile Thr Ala Ala Met Thr Ala Gln Gly Ala Ala 
        35                  40                  45              

Thr Val Ala Val Gly Val Lys Thr Lys Asn Pro Lys Leu Lys Thr Leu 
    50                  55                  60                  

Ala Phe Pro Ala Ala Leu Ser Ala Phe Leu Gly Ile Thr Glu Pro Ala 
65                  70                  75                  80  

Ile Phe Gly Val Asn Leu Arg Phe Arg Lys Pro Phe Phe Leu Ser Leu 
                85                  90                  95      

Ile Ala Gly Ala Ile Gly Gly Gly Leu Ala Ser Ile Leu Gly Leu Ala 
            100                 105                 110         

Gly Thr Gly Asn Gly Ile Thr Ile Ile Pro Gly Thr Met Leu Tyr Val 
        115                 120                 125             

Gly Asn Gly Gln Leu Pro Gln Tyr Leu Leu Met Val Ala Val Ser Phe 
    130                 135                 140                 

Ala Leu Gly Phe Ala Leu Thr Tyr Met Phe Gly Tyr Glu Asp Glu Val 
145                 150                 155                 160 

Asp Ala Thr Ala Ala Ala Lys Arg Ala Glu Val Ala Glu Glu Lys Glu 
                165                 170                 175     

Glu Val Ala Pro Ala Ala Leu Gln Asn Glu Thr Leu Val Thr Pro Ile 
            180                 185                 190         

Val Gly Asp Val Val Ala Leu Ala Asp Val Asn Asp Pro Val Phe Ser 
        195                 200                 205             

Ser Gly Ala Met Gly Gln Gly Ile Val Val Lys Pro Ser Gln Gly Val 
    210                 215                 220                 

Val Tyr Ala Pro Ala Asp Ala Glu Val Ser Ile Ala Phe Pro Thr Gly 
225                 230                 235                 240 

His Ala Phe Gly Leu Lys Thr Arg Asn Gly Ala Glu Val Leu Ile His 
                245                 250                 255     

Val Gly Ile Asp Thr Val Ser Met Asn Gly Asp Gly Phe Glu Thr Lys 
            260                 265                 270         

Val Ala Gln Gly Asn Lys Val Lys Ala Gly Asp Val Leu Gly Thr Phe 
        275                 280                 285             

Asp Ser Asn Lys Ile Ala Ala Ala Gly Leu Asp Asp Thr Thr Met Val 
    290                 295                 300                 

Ile Val Thr Asn Thr Gly Asp Tyr Ala Ser Val Ala Pro Val Ala Thr 
305                 310                 315                 320 

Gly Ser Val Ala Lys Gly Asp Ala Val Ile Glu Val Lys Ile 
                325                 330                 

<210>   3553
<211>   747
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3553
ttgcaaatga acaatcagga aattgcaaaa aaagtcatcg atgccttggg cggacgtgaa   60
aatgtcaata gtgttgccca ctgtgcgact cgtctacgtg tcatggtcaa agatgaagag   120
aaaatcaata aagaagtgat tgagaacttg gaaaaagttc aaggtgcttt ctttaactca   180
gggcaatacc aaattatctt tggtacaggt acagttaaca aaatgtacga tgaagttgtt   240
gtacttggat taccaacatc atctaaggat gacatgaaag cagaagttgc taaacaaggg   300
aactggttcc aacgtgctat ccgtactttt ggtgatgttt tcgttccaat catcccagtt   360
atcgtagcga caggtctctt catgggtgtg cgtggtcttt tcaacgctct tgaaatgcca   420
cttccaggtg actttgcaac ttacacacaa atcttgacag atacagcctt catcatcttg   480
ccaggtttgg ttgtgtggtc aaccttccgt gtatttggtg gaaatcctgc cgttggtatc   540
gttcttggta tgatgcttgt ctctggctca cttccaaacg cttgggcagt tgctcaaggt   600
ggtgaagtaa cagcgatgaa cttctttggt ttcatccctg ttgttggttt gcaaggttcc   660
gttcttccag ccttcatcat cggggttgtc ggagctaaat ttgaaaaagc tgtccgcaag   720
ttgttccaga tgtcattgac ctcttgg                                       747

<210>   3554
<211>   249
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, enzyme IIB
<223>   Cellular location: membrane

<400>   3554
Met Gln Met Asn Asn Gln Glu Ile Ala Lys Lys Val Ile Asp Ala Leu 
1               5                   10                  15      

Gly Gly Arg Glu Asn Val Asn Ser Val Ala His Cys Ala Thr Arg Leu 
            20                  25                  30          

Arg Val Met Val Lys Asp Glu Glu Lys Ile Asn Lys Glu Val Ile Glu 
        35                  40                  45              

Asn Leu Glu Lys Val Gln Gly Ala Phe Phe Asn Ser Gly Gln Tyr Gln 
    50                  55                  60                  

Ile Ile Phe Gly Thr Gly Thr Val Asn Lys Met Tyr Asp Glu Val Val 
65                  70                  75                  80  

Val Leu Gly Leu Pro Thr Ser Ser Lys Asp Asp Met Lys Ala Glu Val 
                85                  90                  95      

Ala Lys Gln Gly Asn Trp Phe Gln Arg Ala Ile Arg Thr Phe Gly Asp 
            100                 105                 110         

Val Phe Val Pro Ile Ile Pro Val Ile Val Ala Thr Gly Leu Phe Met 
        115                 120                 125             

Gly Val Arg Gly Leu Phe Asn Ala Leu Glu Met Pro Leu Pro Gly Asp 
    130                 135                 140                 

Phe Ala Thr Tyr Thr Gln Ile Leu Thr Asp Thr Ala Phe Ile Ile Leu 
145                 150                 155                 160 

Pro Gly Leu Val Val Trp Ser Thr Phe Arg Val Phe Gly Gly Asn Pro 
                165                 170                 175     

Ala Val Gly Ile Val Leu Gly Met Met Leu Val Ser Gly Ser Leu Pro 
            180                 185                 190         

Asn Ala Trp Ala Val Ala Gln Gly Gly Glu Val Thr Ala Met Asn Phe 
        195                 200                 205             

Phe Gly Phe Ile Pro Val Val Gly Leu Gln Gly Ser Val Leu Pro Ala 
    210                 215                 220                 

Phe Ile Ile Gly Val Val Gly Ala Lys Phe Glu Lys Ala Val Arg Lys 
225                 230                 235                 240 

Leu Phe Gln Met Ser Leu Thr Ser Trp 
                245                 

<210>   3555
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3555
atgcaagcct tttatgttaa aaaagaggaa aaactgtcaa aggattatca taaaataaat   60
acaggaaatc aatcaaattt ttacgaaaat gtgaaagata atgaaataaa atacttttta   120
accaaggttt caaacttatt tttcaaggaa ttcctgatga aacagtcaaa aacaatcaat   180
ctaaagcttg cccac                                                    195

<210>   3556
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3556
Met Gln Ala Phe Tyr Val Lys Lys Glu Glu Lys Leu Ser Lys Asp Tyr 
1               5                   10                  15      

His Lys Ile Asn Thr Gly Asn Gln Ser Asn Phe Tyr Glu Asn Val Lys 
            20                  25                  30          

Asp Asn Glu Ile Lys Tyr Phe Leu Thr Lys Val Ser Asn Leu Phe Phe 
        35                  40                  45              

Lys Glu Phe Leu Met Lys Gln Ser Lys Thr Ile Asn Leu Lys Leu Ala 
    50                  55                  60                  

His 
65  

<210>   3557
<211>   1452
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3557
atggaatgga caactgagcg tcgttacaga ctttatcaag attggacgca agaagaaatt   60
caacatataa aggaaaatat ggcacaatct ccatggcata ctcattacca tgttgagcca   120
aaaacaggac ttctcaacga cccaaatggc ttttcttact ttgatggcaa gtggatcctc   180
ttttaccaga attttccttt tggtgcagcc cacggtttaa aatcttgggc acagctagaa   240
agtgatgatt tgattcactt taaagaaact ggaatcaaag ttttaccaga tactccatta   300
gatagccacg gtgcctactc tggttctgcc atgcaatttg gcgataactt attcctattt   360
tatacaggaa atgttcgcga taaaaactgg atccgtcacc cataccagat cggtgctttg   420
atggacaagg agggtaagat tacaaagatt gacaagatct tgattgacca gccagcagac   480
tctactgacc acttccgcga tccacaaatt tttaactttc agggtcaata ttatgccatt   540
gtcggcggac aagacttgga gaaaaaaggt ttcgttcgtc tctacaaggc tgtcaataac   600
gactacacaa actggcaagc agttggcgac cttgactttg ctaacgaccg tactgcctac   660
atgatggaat gtcctaattt ggtctttgta gaggaacaac ctgtccttct ctactgtcca   720
caaggattgg ataagaaagt tctagactac gataatatct ttccaaatat gtataagatc   780
ggggcttcct ttgaccctaa aaatgccaaa atggtagatg tgtctcaact tcaaaacatg   840
gattacggtt tcgaagccta tgcaactcaa gccttcaacg ctcctgatgg gcgtgctcta   900
gcagttagct ggcttggttt gccagatgtt tcttacccat ctgaccgttt tgaccaccaa   960
ggaaccttct ctttggtcaa ggaactcact atcaaagacg acaagctcta ccagtatcca   1020
gtcgctgcta ttaaggacct tcgtgcttct gaagaagcct tctcaaaccg ttcccaaacc   1080
aagaacactt acgaacttga actcaacttg gaagctaata gccagagcga gattgtctta   1140
cttgctgata aagaaggtaa gggactttca atcaactttg accttgtaaa cggtcaagta   1200
acagtggatc gtagccaggc tggagaacag tatgcccaag aatttgggac aactcgttct   1260
tgccctatcg agaatcaggc tactactgct acaatcttca tcgataactc tgtctttgaa   1320
attttcatca ataaaggaga aaaagtattt tctggtcgtg tcttcccaca tgcggaccaa   1380
aatggtatcc tgattaaatc tggaaaccca actggaactt actatgaatt agattatggt   1440
cgcaaaacta ac                                                       1452

<210>   3558
<211>   484
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sucrose-6-phosphate hydrolase (scrB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903610 (0.E+01)

<400>   3558
Met Glu Trp Thr Thr Glu Arg Arg Tyr Arg Leu Tyr Gln Asp Trp Thr 
1               5                   10                  15      

Gln Glu Glu Ile Gln His Ile Lys Glu Asn Met Ala Gln Ser Pro Trp 
            20                  25                  30          

His Thr His Tyr His Val Glu Pro Lys Thr Gly Leu Leu Asn Asp Pro 
        35                  40                  45              

Asn Gly Phe Ser Tyr Phe Asp Gly Lys Trp Ile Leu Phe Tyr Gln Asn 
    50                  55                  60                  

Phe Pro Phe Gly Ala Ala His Gly Leu Lys Ser Trp Ala Gln Leu Glu 
65                  70                  75                  80  

Ser Asp Asp Leu Ile His Phe Lys Glu Thr Gly Ile Lys Val Leu Pro 
                85                  90                  95      

Asp Thr Pro Leu Asp Ser His Gly Ala Tyr Ser Gly Ser Ala Met Gln 
            100                 105                 110         

Phe Gly Asp Asn Leu Phe Leu Phe Tyr Thr Gly Asn Val Arg Asp Lys 
        115                 120                 125             

Asn Trp Ile Arg His Pro Tyr Gln Ile Gly Ala Leu Met Asp Lys Glu 
    130                 135                 140                 

Gly Lys Ile Thr Lys Ile Asp Lys Ile Leu Ile Asp Gln Pro Ala Asp 
145                 150                 155                 160 

Ser Thr Asp His Phe Arg Asp Pro Gln Ile Phe Asn Phe Gln Gly Gln 
                165                 170                 175     

Tyr Tyr Ala Ile Val Gly Gly Gln Asp Leu Glu Lys Lys Gly Phe Val 
            180                 185                 190         

Arg Leu Tyr Lys Ala Val Asn Asn Asp Tyr Thr Asn Trp Gln Ala Val 
        195                 200                 205             

Gly Asp Leu Asp Phe Ala Asn Asp Arg Thr Ala Tyr Met Met Glu Cys 
    210                 215                 220                 

Pro Asn Leu Val Phe Val Glu Glu Gln Pro Val Leu Leu Tyr Cys Pro 
225                 230                 235                 240 

Gln Gly Leu Asp Lys Lys Val Leu Asp Tyr Asp Asn Ile Phe Pro Asn 
                245                 250                 255     

Met Tyr Lys Ile Gly Ala Ser Phe Asp Pro Lys Asn Ala Lys Met Val 
            260                 265                 270         

Asp Val Ser Gln Leu Gln Asn Met Asp Tyr Gly Phe Glu Ala Tyr Ala 
        275                 280                 285             

Thr Gln Ala Phe Asn Ala Pro Asp Gly Arg Ala Leu Ala Val Ser Trp 
    290                 295                 300                 

Leu Gly Leu Pro Asp Val Ser Tyr Pro Ser Asp Arg Phe Asp His Gln 
305                 310                 315                 320 

Gly Thr Phe Ser Leu Val Lys Glu Leu Thr Ile Lys Asp Asp Lys Leu 
                325                 330                 335     

Tyr Gln Tyr Pro Val Ala Ala Ile Lys Asp Leu Arg Ala Ser Glu Glu 
            340                 345                 350         

Ala Phe Ser Asn Arg Ser Gln Thr Lys Asn Thr Tyr Glu Leu Glu Leu 
        355                 360                 365             

Asn Leu Glu Ala Asn Ser Gln Ser Glu Ile Val Leu Leu Ala Asp Lys 
    370                 375                 380                 

Glu Gly Lys Gly Leu Ser Ile Asn Phe Asp Leu Val Asn Gly Gln Val 
385                 390                 395                 400 

Thr Val Asp Arg Ser Gln Ala Gly Glu Gln Tyr Ala Gln Glu Phe Gly 
                405                 410                 415     

Thr Thr Arg Ser Cys Pro Ile Glu Asn Gln Ala Thr Thr Ala Thr Ile 
            420                 425                 430         

Phe Ile Asp Asn Ser Val Phe Glu Ile Phe Ile Asn Lys Gly Glu Lys 
        435                 440                 445             

Val Phe Ser Gly Arg Val Phe Pro His Ala Asp Gln Asn Gly Ile Leu 
    450                 455                 460                 

Ile Lys Ser Gly Asn Pro Thr Gly Thr Tyr Tyr Glu Leu Asp Tyr Gly 
465                 470                 475                 480 

Arg Lys Thr Asn 
                

<210>   3559
<211>   963
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3559
atggtcgcaa aactaactga tgtcgccaaa cttgcaggcg tcagtcctac taccgtttct   60
cgggttatca ataaaaaagg gtatctatct gagaaaacca tccaaaaagt caatgaagcc   120
atgcgagaat tgggctataa acccaacaac ctggctcgta gtctgcaagg aaaatcagct   180
aagttaatcg gcttgatttt ccccaatatt tccaatgttt tctatgcaga attgattgat   240
aaattggaac accaactctt caaaaatggt tacaagacca tcatctgcaa cagtgaacat   300
gattctgaga aggaacgcga atacatcgaa atgttggaag ccaatcaggt ggacggcatc   360
atttctggta gtcacaacct aggaatcgaa gactacaatc gtgtgacagc gccgattatt   420
tcctttgacc gaaacctatc gccagacatc cctgtcgtct cctctgacaa ctatgctggt   480
ggggttcttg ctgcccaaac cttggtcaag acaggtgccc agtctatcat catgattaca   540
gggaatgaca attctaattc gccaaccgga ctgcgccacg ctggttttgc atccgtactc   600
ccaaaagctc ctattatcaa tgtttccagt gacttttctc ccgtcagaaa agaaatggaa   660
atcaagaata tcttgacccg ggaaaaacca gatgccattt ttgcttcgga tgatttgaca   720
gctattctgg tcattaaaat cgctcaagaa ttgggcattt ctgtcccaaa agagctcaag   780
gtcatcggct atgatgggac ctactttatc gaaaattact accctcaatt ggctactatc   840
aagcaacctt tggaagagat tgcttgtctc actattgatc ttctcttgca aaagattgaa   900
ggcaaggaag tcgccacaac tggttacttc ttaccagtta cgctattacc aggaaaaagt   960
att                                                                 963

<210>   3560
<211>   321
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sucrose operon repressor (scrR)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903611 (0.E+01)

<400>   3560
Met Val Ala Lys Leu Thr Asp Val Ala Lys Leu Ala Gly Val Ser Pro 
1               5                   10                  15      

Thr Thr Val Ser Arg Val Ile Asn Lys Lys Gly Tyr Leu Ser Glu Lys 
            20                  25                  30          

Thr Ile Gln Lys Val Asn Glu Ala Met Arg Glu Leu Gly Tyr Lys Pro 
        35                  40                  45              

Asn Asn Leu Ala Arg Ser Leu Gln Gly Lys Ser Ala Lys Leu Ile Gly 
    50                  55                  60                  

Leu Ile Phe Pro Asn Ile Ser Asn Val Phe Tyr Ala Glu Leu Ile Asp 
65                  70                  75                  80  

Lys Leu Glu His Gln Leu Phe Lys Asn Gly Tyr Lys Thr Ile Ile Cys 
                85                  90                  95      


Asn Ser Glu His Asp Ser Glu Lys Glu Arg Glu Tyr Ile Glu Met Leu 
            100                 105                 110         

Glu Ala Asn Gln Val Asp Gly Ile Ile Ser Gly Ser His Asn Leu Gly 
        115                 120                 125             

Ile Glu Asp Tyr Asn Arg Val Thr Ala Pro Ile Ile Ser Phe Asp Arg 
    130                 135                 140                 

Asn Leu Ser Pro Asp Ile Pro Val Val Ser Ser Asp Asn Tyr Ala Gly 
145                 150                 155                 160 

Gly Val Leu Ala Ala Gln Thr Leu Val Lys Thr Gly Ala Gln Ser Ile 
                165                 170                 175     

Ile Met Ile Thr Gly Asn Asp Asn Ser Asn Ser Pro Thr Gly Leu Arg 
            180                 185                 190         

His Ala Gly Phe Ala Ser Val Leu Pro Lys Ala Pro Ile Ile Asn Val 
        195                 200                 205             

Ser Ser Asp Phe Ser Pro Val Arg Lys Glu Met Glu Ile Lys Asn Ile 
    210                 215                 220                 

Leu Thr Arg Glu Lys Pro Asp Ala Ile Phe Ala Ser Asp Asp Leu Thr 
225                 230                 235                 240 

Ala Ile Leu Val Ile Lys Ile Ala Gln Glu Leu Gly Ile Ser Val Pro 
                245                 250                 255     

Lys Glu Leu Lys Val Ile Gly Tyr Asp Gly Thr Tyr Phe Ile Glu Asn 
            260                 265                 270         

Tyr Tyr Pro Gln Leu Ala Thr Ile Lys Gln Pro Leu Glu Glu Ile Ala 
        275                 280                 285             

Cys Leu Thr Ile Asp Leu Leu Leu Gln Lys Ile Glu Gly Lys Glu Val 
    290                 295                 300                 

Ala Thr Thr Gly Tyr Phe Leu Pro Val Thr Leu Leu Pro Gly Lys Ser 
305                 310                 315                 320 

Ile 
    

<210>   3561
<211>   1272
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3561
atgaagataa gttggaatgg attttctaaa aaatcatacc aagagcgcct cgagctgtta   60
aaagctcagg cgctccttag tcctgagaga caagctagtc tggagaagga tgaacagatg   120
agcgtgactg tggcagacca gctgagtgag aatgtagtgg gaactttttc tctgccttat   180
tcactggttc cggaggtact tgtcaacggt caggaataca ccgttcccta tgtgacagaa   240
gaaccctctg tggttgcggc ggccagctat gccagcaaaa tcatcaagcg tgcaggtggt   300
tttactgcac aagtccatca gcgacagatg attgggcagg tagcccttta tcaagttgct   360
aatcctaaac tagcgcaaga gaagattgcc agcaagaaag cggagctctt ggagcttgcc   420
aatcaagcct atccttctat cgttaaacgt ggaggtgggg cgcgtgatct gcatgtcgag   480
cagataaaag gcgaaccaga ctttctcgtt gtttatattc atgtcgatac ccaggaagcc   540
atgggtgcca atatgctcaa caccatgctg gaagccttga aaccagtctt agaagaactc   600
agtcagggac agagtctcat gggaatcctg tccaactacg cgaccgattc tctggtgact   660
gcaagctgtc gcatcgcctt tcgctacttg agccgccaaa aggatcaagg acgagagatt   720
gcggagaaaa ttgcgttggc tagtcagttt gcgcaggctg atccttaccg agctgctact   780
cataataaag gaatttttaa tggtattgat gcgattttga ttgccactgg taatgactgg   840
cgtgccatcg aagctggggc ccatgccttt gccagtcgag atggacgcta tcaaggtctt   900
agctgctgga cgctggacct tgaaagagaa gaattggtcg gtgagatgac cctgcccatg   960
cctgtagcga ctaagggtgg ctctatcggc ctcaacccac gtgtagttct cagtcatgat   1020
ctactaggaa atccttctgc cagagaatta gcccagatta tcgtgtccat cggtcttgct   1080
caaaattttg cagccctcaa agccttggta agtacgggca tccagcaagg ccacatgaaa   1140
ctacaggcca aatccctagc tctcctagct ggggctagtg aatctgaagt tgctccccta   1200
gtagagcgcc tcatctcaga taaaaccttt aacctagaga cagcccagcg ctatctcgaa   1260
aatttaagat ca                                                       1272

<210>   3562
<211>   424
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   3-hydroxy-3-methylglutaryl-CoA reductase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903612 (0.E+01)

<400>   3562
Met Lys Ile Ser Trp Asn Gly Phe Ser Lys Lys Ser Tyr Gln Glu Arg 
1               5                   10                  15      

Leu Glu Leu Leu Lys Ala Gln Ala Leu Leu Ser Pro Glu Arg Gln Ala 
            20                  25                  30          

Ser Leu Glu Lys Asp Glu Gln Met Ser Val Thr Val Ala Asp Gln Leu 
        35                  40                  45              

Ser Glu Asn Val Val Gly Thr Phe Ser Leu Pro Tyr Ser Leu Val Pro 
    50                  55                  60                  

Glu Val Leu Val Asn Gly Gln Glu Tyr Thr Val Pro Tyr Val Thr Glu 
65                  70                  75                  80  

Glu Pro Ser Val Val Ala Ala Ala Ser Tyr Ala Ser Lys Ile Ile Lys 
                85                  90                  95      

Arg Ala Gly Gly Phe Thr Ala Gln Val His Gln Arg Gln Met Ile Gly 
            100                 105                 110         

Gln Val Ala Leu Tyr Gln Val Ala Asn Pro Lys Leu Ala Gln Glu Lys 
        115                 120                 125             

Ile Ala Ser Lys Lys Ala Glu Leu Leu Glu Leu Ala Asn Gln Ala Tyr 
    130                 135                 140                 

Pro Ser Ile Val Lys Arg Gly Gly Gly Ala Arg Asp Leu His Val Glu 
145                 150                 155                 160 

Gln Ile Lys Gly Glu Pro Asp Phe Leu Val Val Tyr Ile His Val Asp 
                165                 170                 175     

Thr Gln Glu Ala Met Gly Ala Asn Met Leu Asn Thr Met Leu Glu Ala 
            180                 185                 190         

Leu Lys Pro Val Leu Glu Glu Leu Ser Gln Gly Gln Ser Leu Met Gly 
        195                 200                 205             

Ile Leu Ser Asn Tyr Ala Thr Asp Ser Leu Val Thr Ala Ser Cys Arg 
    210                 215                 220                 

Ile Ala Phe Arg Tyr Leu Ser Arg Gln Lys Asp Gln Gly Arg Glu Ile 
225                 230                 235                 240 

Ala Glu Lys Ile Ala Leu Ala Ser Gln Phe Ala Gln Ala Asp Pro Tyr 
                245                 250                 255     

Arg Ala Ala Thr His Asn Lys Gly Ile Phe Asn Gly Ile Asp Ala Ile 
            260                 265                 270         

Leu Ile Ala Thr Gly Asn Asp Trp Arg Ala Ile Glu Ala Gly Ala His 
        275                 280                 285             

Ala Phe Ala Ser Arg Asp Gly Arg Tyr Gln Gly Leu Ser Cys Trp Thr 
    290                 295                 300                 

Leu Asp Leu Glu Arg Glu Glu Leu Val Gly Glu Met Thr Leu Pro Met 
305                 310                 315                 320 

Pro Val Ala Thr Lys Gly Gly Ser Ile Gly Leu Asn Pro Arg Val Val 
                325                 330                 335     

Leu Ser His Asp Leu Leu Gly Asn Pro Ser Ala Arg Glu Leu Ala Gln 
            340                 345                 350         

Ile Ile Val Ser Ile Gly Leu Ala Gln Asn Phe Ala Ala Leu Lys Ala 
        355                 360                 365             

Leu Val Ser Thr Gly Ile Gln Gln Gly His Met Lys Leu Gln Ala Lys 
    370                 375                 380                 

Ser Leu Ala Leu Leu Ala Gly Ala Ser Glu Ser Glu Val Ala Pro Leu 
385                 390                 395                 400 

Val Glu Arg Leu Ile Ser Asp Lys Thr Phe Asn Leu Glu Thr Ala Gln 
                405                 410                 415     

Arg Tyr Leu Glu Asn Leu Arg Ser 
            420                 

<210>   3563
<211>   1194
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3563
atgaatgata aaacagaggt aaatatgaca atcggtattg ataagattgg ttttgcgacc   60
agtcaatatg tcttgaaatt acaagactta gcagaagcga ggggaattga ccctgaaaaa   120
ttaagtaaag gactcttact caaggaattg agtattgcgc ccctaactga ggatatcgtg   180
accttggcgg ccagtgctag tgactctatt ttaactgagc aagaaagaca agaagttgac   240
atggtcattg tggcgaccga gtcaggaatt gaccagagta aggctgcggc cgtctttgtg   300
catggcttgc tgggcatcca gccctttgct cgtagtttcg agattaaaga agcctgctac   360
ggagcgactg ctgccctcca ttatgccaaa ttgcatgtgg aaaattctcc ggagtccaag   420
gtcttggtca ttgccagtga tattgccaaa tacggtattg aaactccagg agaaccaact   480
caaggtgctg gaagtgtagc tatgttgatt acacaaaatc cacgcatgat ggcctttaat   540
aatgacaatg tagctcagac ccgtgacatc atggatttct ggcgaccaaa ttactcgaca   600
actccttatg taaatggtgt ctattctacc caacaatact tggatagttt gaaaacgact   660

tggcttgaat atcaaaaacg ctaccagctt actttggatg attttgcggc tgtttgtttc   720
cacttgcctt atcctaaatt agcgctaaaa ggcttgaaaa aaatcatgga taagagcctg   780
cctcaagaga aaaaagacct cttacaaaag cattttgacc agtctattct ctacagtcaa   840
aaggtgggga atatctacac aggttcactt ttccttggac ttttgtctct cttggaaaat   900
acagatagct tgaaagctgg ggataaaatc gccctttata gttacggaag tggagctgtg   960
gctgagttct tcagtggtga attggttgaa ggatatgaag cttatttgga taaagaccgt   1020
ttgaacaagc tcaaccaacg aactgcccta tccgttgcag actatgaaaa ggtctttttt   1080
gaggaagtaa acttggatga aactaactct gcccagtttg ctggctatga aaatcaagat   1140
tttgccttgg ttgaaattct cgaccaccaa cgccgttata gcaaggttga aaaa         1194

<210>   3564
<211>   398
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydroxymethylglutaryl-CoA synthase (mvaS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903613 (0.E+01)

<400>   3564
Met Asn Asp Lys Thr Glu Val Asn Met Thr Ile Gly Ile Asp Lys Ile 
1               5                   10                  15      

Gly Phe Ala Thr Ser Gln Tyr Val Leu Lys Leu Gln Asp Leu Ala Glu 
            20                  25                  30          

Ala Arg Gly Ile Asp Pro Glu Lys Leu Ser Lys Gly Leu Leu Leu Lys 
        35                  40                  45              

Glu Leu Ser Ile Ala Pro Leu Thr Glu Asp Ile Val Thr Leu Ala Ala 
    50                  55                  60                  

Ser Ala Ser Asp Ser Ile Leu Thr Glu Gln Glu Arg Gln Glu Val Asp 
65                  70                  75                  80  

Met Val Ile Val Ala Thr Glu Ser Gly Ile Asp Gln Ser Lys Ala Ala 
                85                  90                  95      

Ala Val Phe Val His Gly Leu Leu Gly Ile Gln Pro Phe Ala Arg Ser 
            100                 105                 110         

Phe Glu Ile Lys Glu Ala Cys Tyr Gly Ala Thr Ala Ala Leu His Tyr 
        115                 120                 125             

Ala Lys Leu His Val Glu Asn Ser Pro Glu Ser Lys Val Leu Val Ile 
    130                 135                 140                 

Ala Ser Asp Ile Ala Lys Tyr Gly Ile Glu Thr Pro Gly Glu Pro Thr 
145                 150                 155                 160 

Gln Gly Ala Gly Ser Val Ala Met Leu Ile Thr Gln Asn Pro Arg Met 
                165                 170                 175     

Met Ala Phe Asn Asn Asp Asn Val Ala Gln Thr Arg Asp Ile Met Asp 
            180                 185                 190         

Phe Trp Arg Pro Asn Tyr Ser Thr Thr Pro Tyr Val Asn Gly Val Tyr 
        195                 200                 205             

Ser Thr Gln Gln Tyr Leu Asp Ser Leu Lys Thr Thr Trp Leu Glu Tyr 
    210                 215                 220                 

Gln Lys Arg Tyr Gln Leu Thr Leu Asp Asp Phe Ala Ala Val Cys Phe 
225                 230                 235                 240 

His Leu Pro Tyr Pro Lys Leu Ala Leu Lys Gly Leu Lys Lys Ile Met 
                245                 250                 255     

Asp Lys Ser Leu Pro Gln Glu Lys Lys Asp Leu Leu Gln Lys His Phe 
            260                 265                 270         

Asp Gln Ser Ile Leu Tyr Ser Gln Lys Val Gly Asn Ile Tyr Thr Gly 
        275                 280                 285             

Ser Leu Phe Leu Gly Leu Leu Ser Leu Leu Glu Asn Thr Asp Ser Leu 
    290                 295                 300                 

Lys Ala Gly Asp Lys Ile Ala Leu Tyr Ser Tyr Gly Ser Gly Ala Val 
305                 310                 315                 320 

Ala Glu Phe Phe Ser Gly Glu Leu Val Glu Gly Tyr Glu Ala Tyr Leu 
                325                 330                 335     

Asp Lys Asp Arg Leu Asn Lys Leu Asn Gln Arg Thr Ala Leu Ser Val 
            340                 345                 350         

Ala Asp Tyr Glu Lys Val Phe Phe Glu Glu Val Asn Leu Asp Glu Thr 
        355                 360                 365             

Asn Ser Ala Gln Phe Ala Gly Tyr Glu Asn Gln Asp Phe Ala Leu Val 
    370                 375                 380                 

Glu Ile Leu Asp His Gln Arg Arg Tyr Ser Lys Val Glu Lys 
385                 390                 395             

<210>   3565
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3565
ttgtctgtaa atctactgac cttgttgttt atcccagtca tggtttctag ttcgggctca   60
gagtttcaaa gtggatggca agagcatcaa ttgattgctg agaaggttag taaaacactt   120
gataagacat ttgataagga tgtcagagaa attccgacca gtcagtttta tcaaaaattt   180
gtagatgaga tgggaaggac ttactcagga aatttgatcc tccaggagct gataactgtg   240
aatggagctt ataaagctac ttatatcggt gaactctcta gcaac                   285

<210>   3566
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903614 (2.E-49)

<400>   3566
Met Ser Val Asn Leu Leu Thr Leu Leu Phe Ile Pro Val Met Val Ser 
1               5                   10                  15      

Ser Ser Gly Ser Glu Phe Gln Ser Gly Trp Gln Glu His Gln Leu Ile 
            20                  25                  30          

Ala Glu Lys Val Ser Lys Thr Leu Asp Lys Thr Phe Asp Lys Asp Val 
        35                  40                  45              

Arg Glu Ile Pro Thr Ser Gln Phe Tyr Gln Lys Phe Val Asp Glu Met 
    50                  55                  60                  

Gly Arg Thr Tyr Ser Gly Asn Leu Ile Leu Gln Glu Leu Ile Thr Val 
65                  70                  75                  80  

Asn Gly Ala Tyr Lys Ala Thr Tyr Ile Gly Glu Leu Ser Ser Asn 
                85                  90                  95  

<210>   3567
<211>   618
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3567
gtgcgagaat accgcactta tgaagaaatt gcggctgatt ttggtatcca cgaaagcaac   60
ttaatccgtc ggagccaatg ggttgaagta actcttgttc aaagtggtgt tacgatttca   120
agaactcctc tcagctttga ggacacgata atgattgatg tgacggaagt aaaaatcaat   180
cgccctaaaa aacaattagc gaatgattct ggtaaaaaga aatttcacgc tatgaaggct   240
caagcgattg tcacaagtca agggagaatt gtttctttgg atatcgctgt gaactatagt   300
catgatatga agttgttcaa aatgagttgc agaaatatcg gacaagctgg taaaatcttg   360
gctgacagtg attatcaagg gctcatgaag atatatcctc aagcacaaac tccacgtaaa   420
tccagcaaac tcaagccgct aacagctgaa gataaagcct gtaaccatgc gctatctaag   480
gagagaagca aggttgagaa catctttgcc aaagtaaaaa cgtttaaaat gttttcaaca   540
acctatcgaa atcatcgtaa acgcttcgga ttacgaatga atttgattgc tggtattatc   600
aatcatgaac taggattc                                                 618

<210>   3568
<211>   206
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA/OrfB, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903038 (6.E-68)

<400>   3568
Met Arg Glu Tyr Arg Thr Tyr Glu Glu Ile Ala Ala Asp Phe Gly Ile 
1               5                   10                  15      

His Glu Ser Asn Leu Ile Arg Arg Ser Gln Trp Val Glu Val Thr Leu 
            20                  25                  30          

Val Gln Ser Gly Val Thr Ile Ser Arg Thr Pro Leu Ser Phe Glu Asp 
        35                  40                  45              

Thr Ile Met Ile Asp Val Thr Glu Val Lys Ile Asn Arg Pro Lys Lys 
    50                  55                  60                  

Gln Leu Ala Asn Asp Ser Gly Lys Lys Lys Phe His Ala Met Lys Ala 
65                  70                  75                  80  

Gln Ala Ile Val Thr Ser Gln Gly Arg Ile Val Ser Leu Asp Ile Ala 
                85                  90                  95      

Val Asn Tyr Ser His Asp Met Lys Leu Phe Lys Met Ser Cys Arg Asn 
            100                 105                 110         

Ile Gly Gln Ala Gly Lys Ile Leu Ala Asp Ser Asp Tyr Gln Gly Leu 
        115                 120                 125             

Met Lys Ile Tyr Pro Gln Ala Gln Thr Pro Arg Lys Ser Ser Lys Leu 
    130                 135                 140                 

Lys Pro Leu Thr Ala Glu Asp Lys Ala Cys Asn His Ala Leu Ser Lys 
145                 150                 155                 160 

Glu Arg Ser Lys Val Glu Asn Ile Phe Ala Lys Val Lys Thr Phe Lys 
                165                 170                 175     

Met Phe Ser Thr Thr Tyr Arg Asn His Arg Lys Arg Phe Gly Leu Arg 
            180                 185                 190         

Met Asn Leu Ile Ala Gly Ile Ile Asn His Glu Leu Gly Phe 
        195                 200                 205     

<210>   3569
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3569
atgacactaa caaccttttt attacaagca gtagcaagtt ttcttgccat tatcactttt   60
ttaatcgtac tcaatgtgca acggtctatg ctcttacctg gagggatttt gggcatgact   120
gtctggctaa tctatctctt gctcaaggaa ccgaccaatg tcattgtagc taccttcatt   180
gcagccatta ttggttcttg tgtcagccag attttaagta ttctttataa gacacctgct   240
gtggtcttta tcttggccat tttggcaccg ctggttccag gttatctctc ctaccgaaca   300
actgcctttt ttgtgacagg ggactataat aaagcactgg caagtgcgac cttggttgtc   360
atgttggctt tggtaatctc tattggaatg gctagcggaa cagtgattct cagactctat   420
cattatataa aaacacatcg agtatcg                                       447

<210>   3570
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903617 (3.E-77)

<400>   3570
Met Thr Leu Thr Thr Phe Leu Leu Gln Ala Val Ala Ser Phe Leu Ala 
1               5                   10                  15      

Ile Ile Thr Phe Leu Ile Val Leu Asn Val Gln Arg Ser Met Leu Leu 
            20                  25                  30          

Pro Gly Gly Ile Leu Gly Met Thr Val Trp Leu Ile Tyr Leu Leu Leu 
        35                  40                  45              

Lys Glu Pro Thr Asn Val Ile Val Ala Thr Phe Ile Ala Ala Ile Ile 
    50                  55                  60                  

Gly Ser Cys Val Ser Gln Ile Leu Ser Ile Leu Tyr Lys Thr Pro Ala 
65                  70                  75                  80  

Val Val Phe Ile Leu Ala Ile Leu Ala Pro Leu Val Pro Gly Tyr Leu 
                85                  90                  95      

Ser Tyr Arg Thr Thr Ala Phe Phe Val Thr Gly Asp Tyr Asn Lys Ala 
            100                 105                 110         

Leu Ala Ser Ala Thr Leu Val Val Met Leu Ala Leu Val Ile Ser Ile 
        115                 120                 125             

Gly Met Ala Ser Gly Thr Val Ile Leu Arg Leu Tyr His Tyr Ile Lys 
    130                 135                 140                 

Thr His Arg Val Ser 
145                 

<210>   3571
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3571
atggaagaat caaaagaatt aaatgccgtc attgatgtga ttatgctagc ggggactatt   60
ctccttaaaa gtggctcaga aatccatcgt gtagaagata ccatgattcg aatcgcgcat   120
tcgcagggga ttgtggattg caatgtcctt gccatgcctg ccgctatctt tttctctatt   180
gaaaatacca atatttcgcg catgaagcgc gtgacctcct cttcttataa catcgaaaaa   240
gtctgcgatg tgaaccagat ttctcgtcag ctagttgggg ggcagattga cttagaaaca   300
gcctttaagc aattgacggc cttgcaagcc aaaccccttc cctatactaa gttgcaggta   360
actctggctg cgacctttag tgctcctttc ttttcagtta tgtttagcgg aaatatctac   420
gacgcacttg gggcaggagt ggcgacctta tttggttttg ccttttccct ctatgtggaa   480
aaatttatcc gaattccctt tgtgacagcc tttgctggag cctttgtctt tgggataatt   540
gcccagtttt gggctcgcta cacaggtttt ccttcaacgg cagatttgat tatagctggt   600
gcggtcatgc cgtttgtacc aggtattgcc ttgaccaatg cggtccgtga tattatgacc   660
aaccacataa actctggtat gagtaagatg tttgaatccc tgctcattac cctcgcttta   720
ggggcaggaa cttctgtcgc cttggtattg atgaac                             756

<210>   3572
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903618 (e-138)

<400>   3572
Met Glu Glu Ser Lys Glu Leu Asn Ala Val Ile Asp Val Ile Met Leu 
1               5                   10                  15      

Ala Gly Thr Ile Leu Leu Lys Ser Gly Ser Glu Ile His Arg Val Glu 
            20                  25                  30          

Asp Thr Met Ile Arg Ile Ala His Ser Gln Gly Ile Val Asp Cys Asn 
        35                  40                  45              

Val Leu Ala Met Pro Ala Ala Ile Phe Phe Ser Ile Glu Asn Thr Asn 
    50                  55                  60                  

Ile Ser Arg Met Lys Arg Val Thr Ser Ser Ser Tyr Asn Ile Glu Lys 
65                  70                  75                  80  

Val Cys Asp Val Asn Gln Ile Ser Arg Gln Leu Val Gly Gly Gln Ile 
                85                  90                  95      

Asp Leu Glu Thr Ala Phe Lys Gln Leu Thr Ala Leu Gln Ala Lys Pro 
            100                 105                 110         

Leu Pro Tyr Thr Lys Leu Gln Val Thr Leu Ala Ala Thr Phe Ser Ala 
        115                 120                 125             

Pro Phe Phe Ser Val Met Phe Ser Gly Asn Ile Tyr Asp Ala Leu Gly 
    130                 135                 140                 

Ala Gly Val Ala Thr Leu Phe Gly Phe Ala Phe Ser Leu Tyr Val Glu 
145                 150                 155                 160 

Lys Phe Ile Arg Ile Pro Phe Val Thr Ala Phe Ala Gly Ala Phe Val 
                165                 170                 175     

Phe Gly Ile Ile Ala Gln Phe Trp Ala Arg Tyr Thr Gly Phe Pro Ser 
            180                 185                 190         

Thr Ala Asp Leu Ile Ile Ala Gly Ala Val Met Pro Phe Val Pro Gly 
        195                 200                 205             

Ile Ala Leu Thr Asn Ala Val Arg Asp Ile Met Thr Asn His Ile Asn 
    210                 215                 220                 

Ser Gly Met Ser Lys Met Phe Glu Ser Leu Leu Ile Thr Leu Ala Leu 
225                 230                 235                 240 

Gly Ala Gly Thr Ser Val Ala Leu Val Leu Met Asn 
                245                 250         

<210>   3573
<211>   1977
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3573
atgatccaaa tcggcaagat ttttgccgga cgctatcgga ttgtcaaaca gattggtcga   60
ggaggtatgg cggatgtcta cctagccaaa gacttaatct tagatgggga agaagtggca   120
gtgaaggttc tgaggaccaa ctaccagacg gacccgatag ctgtagctcg ttttcagcgt   180
gaagcgagag ctatggcaga tctagaccat cctcatatcg ttcggataac agatattggc   240
gaggaagacg gtcaacagta cctagctatg gagtatgtgg ctggactgga cctcaaacgc   300
tatatcaagg aacattatcc tctttctaat gaagaagcag tccgtatcat gggacaaatt   360
ctcttggcta tgcgcttggc ccatactcga ggaattgttc acagggactt gaaacctcaa   420
aatatcctct tgacaccaga tgggactgcc aaggtcacag actttgggat tgctgtagcc   480
tttgcagaga caagtctgac ccagactaac tcgatgttgg gctcagttca ttacttgtca   540
ccagagcagg cgcgtggttc gaaggcgact gtgcagagtg atatctatgc catggggatt   600
attttctatg agatgctgac aggccatatc ccttatgacg gggatagcgc ggtgaccatt   660
gccctccagc atttccagaa acccctgccg tccgttattg cagaaaatcc atctgtacct   720
caggctttag aaaatgttat tatcaaggca actgctaaaa agttgaccaa tcgctaccgc   780
tcggtttcag agatgtatgt ggacttgtct agtagcttgt cctacaatcg tagaaatgaa   840
agtaagttaa tctttgatga aacgagcaag gcagatacca agaccttgcc gaaggtttct   900
cagagtacct tgacatctat tcctaaggtt caagcgcaaa cagaacacaa atcaatcaaa   960
aacccaagcc aggctgtgac agaggaaact taccaaccac aagcaccgaa aaaacataga   1020
tttaagatgc gttacctgat tttgttggcc agccttgtat tggtggcagc ttctcttatt   1080
tggatactat ccagaactcc tgcaaccatt gccattccag atgtggcagg tcagacagtt   1140
gcagaggcca aggcaacgct caaaaaagcc aattttgaga ttggtgagga gaagacagag   1200
gctagtgaaa aggtggaaga agggcggatt atccgtacag atcctggcgc tggaactggt   1260
cgaaaagaag gaacgaaaat caatttggtt gtctcatcag gcaagcaatc tttccaaatt   1320
agtaattatg tcggtcggaa atcctctgat gtcattgcgg aattaaaaga gaaaaaagtt   1380
ccagataatt tgattaaaat tgaggaagaa gagtcgaatg agagtgaggc tggaacggtc   1440
ctgaagcaaa gtctaccaga aggtacgacc tatgacttga gcaaggcaac tcaaattgtt   1500
ttgacagtag ctaaaaaagc tacgacgatt caattaggga actatattgg acggaactct   1560
acagaagtaa tctcagaact caagcagaag aaggttcctg agaatttgat taagatagag   1620
gaagaagagt ccagcgaaag cgaaccagga acgattatga aacaaagtcc aggtgccgga   1680
acgacttatg atgtgagtaa acctactcaa attgtcttga cagtagctaa aaaagttaca   1740
agtgttgcca tgccgagtta cattggttct agcttggagt ttactaagaa caatttgatt   1800
caaattgttg ggattaagga agctaatata gaagttgtag aagtgacgac agcgcctgca   1860
ggtagtgcag aaggcatggt tgttgaacaa agtcctagag caggtgaaaa ggtagacctc   1920
aataagacta gagtcaagat ttcaatctac aaacctaaaa caacttcagc tactcct      1977

<210>   3574
<211>   659
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   serine/threonine protein kinase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903619 (0.E+01)

<400>   3574
Met Ile Gln Ile Gly Lys Ile Phe Ala Gly Arg Tyr Arg Ile Val Lys 
1               5                   10                  15      

Gln Ile Gly Arg Gly Gly Met Ala Asp Val Tyr Leu Ala Lys Asp Leu 
            20                  25                  30          

Ile Leu Asp Gly Glu Glu Val Ala Val Lys Val Leu Arg Thr Asn Tyr 
        35                  40                  45              

Gln Thr Asp Pro Ile Ala Val Ala Arg Phe Gln Arg Glu Ala Arg Ala 
    50                  55                  60                  

Met Ala Asp Leu Asp His Pro His Ile Val Arg Ile Thr Asp Ile Gly 
65                  70                  75                  80  

Glu Glu Asp Gly Gln Gln Tyr Leu Ala Met Glu Tyr Val Ala Gly Leu 
                85                  90                  95      

Asp Leu Lys Arg Tyr Ile Lys Glu His Tyr Pro Leu Ser Asn Glu Glu 
            100                 105                 110         

Ala Val Arg Ile Met Gly Gln Ile Leu Leu Ala Met Arg Leu Ala His 
        115                 120                 125             

Thr Arg Gly Ile Val His Arg Asp Leu Lys Pro Gln Asn Ile Leu Leu 
    130                 135                 140                 

Thr Pro Asp Gly Thr Ala Lys Val Thr Asp Phe Gly Ile Ala Val Ala 
145                 150                 155                 160 

Phe Ala Glu Thr Ser Leu Thr Gln Thr Asn Ser Met Leu Gly Ser Val 
                165                 170                 175     

His Tyr Leu Ser Pro Glu Gln Ala Arg Gly Ser Lys Ala Thr Val Gln 
            180                 185                 190         

Ser Asp Ile Tyr Ala Met Gly Ile Ile Phe Tyr Glu Met Leu Thr Gly 
        195                 200                 205             

His Ile Pro Tyr Asp Gly Asp Ser Ala Val Thr Ile Ala Leu Gln His 
    210                 215                 220                 


Phe Gln Lys Pro Leu Pro Ser Val Ile Ala Glu Asn Pro Ser Val Pro 
225                 230                 235                 240 

Gln Ala Leu Glu Asn Val Ile Ile Lys Ala Thr Ala Lys Lys Leu Thr 
                245                 250                 255     

Asn Arg Tyr Arg Ser Val Ser Glu Met Tyr Val Asp Leu Ser Ser Ser 
            260                 265                 270         

Leu Ser Tyr Asn Arg Arg Asn Glu Ser Lys Leu Ile Phe Asp Glu Thr 
        275                 280                 285             

Ser Lys Ala Asp Thr Lys Thr Leu Pro Lys Val Ser Gln Ser Thr Leu 
    290                 295                 300                 

Thr Ser Ile Pro Lys Val Gln Ala Gln Thr Glu His Lys Ser Ile Lys 
305                 310                 315                 320 

Asn Pro Ser Gln Ala Val Thr Glu Glu Thr Tyr Gln Pro Gln Ala Pro 
                325                 330                 335     

Lys Lys His Arg Phe Lys Met Arg Tyr Leu Ile Leu Leu Ala Ser Leu 
            340                 345                 350         

Val Leu Val Ala Ala Ser Leu Ile Trp Ile Leu Ser Arg Thr Pro Ala 
        355                 360                 365             

Thr Ile Ala Ile Pro Asp Val Ala Gly Gln Thr Val Ala Glu Ala Lys 
    370                 375                 380                 

Ala Thr Leu Lys Lys Ala Asn Phe Glu Ile Gly Glu Glu Lys Thr Glu 
385                 390                 395                 400 

Ala Ser Glu Lys Val Glu Glu Gly Arg Ile Ile Arg Thr Asp Pro Gly 
                405                 410                 415     

Ala Gly Thr Gly Arg Lys Glu Gly Thr Lys Ile Asn Leu Val Val Ser 
            420                 425                 430         

Ser Gly Lys Gln Ser Phe Gln Ile Ser Asn Tyr Val Gly Arg Lys Ser 
        435                 440                 445             

Ser Asp Val Ile Ala Glu Leu Lys Glu Lys Lys Val Pro Asp Asn Leu 
    450                 455                 460                 

Ile Lys Ile Glu Glu Glu Glu Ser Asn Glu Ser Glu Ala Gly Thr Val 
465                 470                 475                 480 

Leu Lys Gln Ser Leu Pro Glu Gly Thr Thr Tyr Asp Leu Ser Lys Ala 
                485                 490                 495     

Thr Gln Ile Val Leu Thr Val Ala Lys Lys Ala Thr Thr Ile Gln Leu 
            500                 505                 510         

Gly Asn Tyr Ile Gly Arg Asn Ser Thr Glu Val Ile Ser Glu Leu Lys 
        515                 520                 525             

Gln Lys Lys Val Pro Glu Asn Leu Ile Lys Ile Glu Glu Glu Glu Ser 
    530                 535                 540                 

Ser Glu Ser Glu Pro Gly Thr Ile Met Lys Gln Ser Pro Gly Ala Gly 
545                 550                 555                 560 


Thr Thr Tyr Asp Val Ser Lys Pro Thr Gln Ile Val Leu Thr Val Ala 
                565                 570                 575     

Lys Lys Val Thr Ser Val Ala Met Pro Ser Tyr Ile Gly Ser Ser Leu 
            580                 585                 590         

Glu Phe Thr Lys Asn Asn Leu Ile Gln Ile Val Gly Ile Lys Glu Ala 
        595                 600                 605             

Asn Ile Glu Val Val Glu Val Thr Thr Ala Pro Ala Gly Ser Ala Glu 
    610                 615                 620                 

Gly Met Val Val Glu Gln Ser Pro Arg Ala Gly Glu Lys Val Asp Leu 
625                 630                 635                 640 

Asn Lys Thr Arg Val Lys Ile Ser Ile Tyr Lys Pro Lys Thr Thr Ser 
                645                 650                 655     

Ala Thr Pro 
            

<210>   3575
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3575
atggaaattt cattattaac agatgttggt cagaaacgaa caaataacca agactatgtc   60
aaccactatg tcaatagagc tggacgtacc atgattattt tagctgatgg gatgggaggt   120
catcgcgcag ggaatatcgc tagtgaaatg gcggtcacag acctgggtgt agcttgggtt   180
gatacccaga tcgatacagt caatgaagtg cgtgaatggt tcgcccatta cctagaaatt   240
gaaaatcaaa agattcacca gcttggtcag gatgaagctt acagaggcat gggaactact   300
ttggaagtcc ttgctattat tgataatcag gctatctatg ctcatattgg tgattcgcgt   360
atcggcttga ttcgtggaga agaataccat cagttgacga gcgatcattc cttggttaat   420
gaattgctca aggctggtca attgacacca gaagaggcag aagctcatcc gcaaaaaaat   480
attatcaccc agtctattgg gcaaaaagat gaaattcagc ctgattttgg gacagttatc   540
cttgagtcag gtgactatct cttgctcaat agtgacggct tgaccaacat gatttcaggc   600
agtgagattc gtgatattgt aaccagtgat attcctttag cagataaaac ggagacactt   660
gttcgttttg ctaacaatgc aggaggttta gacaacatta cggttgccct tgtttctatg   720
aacgaggagg atgcagaa                                                 738

<210>   3576
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphatase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903620 (e-139)

<400>   3576
Met Glu Ile Ser Leu Leu Thr Asp Val Gly Gln Lys Arg Thr Asn Asn 
1               5                   10                  15      

Gln Asp Tyr Val Asn His Tyr Val Asn Arg Ala Gly Arg Thr Met Ile 
            20                  25                  30          

Ile Leu Ala Asp Gly Met Gly Gly His Arg Ala Gly Asn Ile Ala Ser 
        35                  40                  45              

Glu Met Ala Val Thr Asp Leu Gly Val Ala Trp Val Asp Thr Gln Ile 
    50                  55                  60                  

Asp Thr Val Asn Glu Val Arg Glu Trp Phe Ala His Tyr Leu Glu Ile 
65                  70                  75                  80  

Glu Asn Gln Lys Ile His Gln Leu Gly Gln Asp Glu Ala Tyr Arg Gly 
                85                  90                  95      

Met Gly Thr Thr Leu Glu Val Leu Ala Ile Ile Asp Asn Gln Ala Ile 
            100                 105                 110         

Tyr Ala His Ile Gly Asp Ser Arg Ile Gly Leu Ile Arg Gly Glu Glu 
        115                 120                 125             

Tyr His Gln Leu Thr Ser Asp His Ser Leu Val Asn Glu Leu Leu Lys 
    130                 135                 140                 

Ala Gly Gln Leu Thr Pro Glu Glu Ala Glu Ala His Pro Gln Lys Asn 
145                 150                 155                 160 

Ile Ile Thr Gln Ser Ile Gly Gln Lys Asp Glu Ile Gln Pro Asp Phe 
                165                 170                 175     

Gly Thr Val Ile Leu Glu Ser Gly Asp Tyr Leu Leu Leu Asn Ser Asp 
            180                 185                 190         

Gly Leu Thr Asn Met Ile Ser Gly Ser Glu Ile Arg Asp Ile Val Thr 
        195                 200                 205             

Ser Asp Ile Pro Leu Ala Asp Lys Thr Glu Thr Leu Val Arg Phe Ala 
    210                 215                 220                 

Asn Asn Ala Gly Gly Leu Asp Asn Ile Thr Val Ala Leu Val Ser Met 
225                 230                 235                 240 

Asn Glu Glu Asp Ala Glu 
                245     

<210>   3577
<211>   1314

<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3577
ttggtgacta aagtagaaac ggctagaagt ttagctctag cagtgctaga ggatgttttt   60
gtgaaccaag catattcaaa tatcgcctta aataagcatc taaagggaag tcaacttttg   120
gcagcagaca agggcttagt gaccgagctg gtctatggaa cggtagcccg taaactgact   180
ctggaatggt acctatccca ctttatcgaa gacagagacc agttagacag ctggctctat   240
gtccttcttc tcatgagtgc ctaccaactc cgctatttgg acaagattcc agatcatgct   300
gtggttaatg aagcagtgga attggccaaa ctccgtaaaa aaggcagtga aaaattggtc   360
aacgctgtcc ttcgccgtat cttgcgtgaa ggctggccag atattgctag catcaagcga   420
aaaaacaagc gtgactccat tgcctattct ctcccagttt ggctagttgc caaactcaag   480
gaagaatacg gagaggagag agcaaaagcc atctttgaaa gcctgttagt gcgaaacaaa   540
gccagtattc gtgtaacaga cctaagtcga aaagaggaaa tccaagcctt gttggaggcg   600
aataattccc ttttagcaac cactggtctg gttaaggagc aggggcattt tgcagggcat   660
aatttgtttg cggatggagc cattaccatc caagatgagt ccagtcagct ggttgctccg   720
acgcttgatt tacaaggtga tgagcgagtg cttgatgcct gtgcggctcc aggtgggaaa   780
acagcccata tagcctctta tcttacgaca ggtcaggtta ctgctctgga cttgtacgac   840
cacaagttgg atttaattca agaaaatgcc caacgtctgg gagttgaaga tcgggttcaa   900
actcaaaaat tggatgccag aaaggtgcat gagttttttg accaggattc ctttgataag   960
attttggtgg atgctccttg ttcaggaatc ggtcttttgc gccgaaaacc agatatcaaa   1020
tacaataaag aaacggcaga tttcgcgtcc ttgcaggaaa ttcagttaga aatattaggt   1080
agtgtttgtc aaatactagg caaaggtggt ataataactt atagcacctg cactatcgtc   1140
tcagaggaga attttcaagt cgttaaggcc tttttagaga gtcatcccga gttcgagcag   1200
gtaaaactag aacatgaatg taaggatatc atgaaagacg gctgtatcct cattacacct   1260
gaattgtatg gaagtgatgg attcttcatc agtcaatttc gcaagatatc ggat         1314

<210>   3578
<211>   438
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   rRNA methyltransferase RsmB (rsmB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903621 (0.E+01)

<400>   3578
Met Val Thr Lys Val Glu Thr Ala Arg Ser Leu Ala Leu Ala Val Leu 
1               5                   10                  15      

Glu Asp Val Phe Val Asn Gln Ala Tyr Ser Asn Ile Ala Leu Asn Lys 
            20                  25                  30          

His Leu Lys Gly Ser Gln Leu Leu Ala Ala Asp Lys Gly Leu Val Thr 
        35                  40                  45              

Glu Leu Val Tyr Gly Thr Val Ala Arg Lys Leu Thr Leu Glu Trp Tyr 
    50                  55                  60                  

Leu Ser His Phe Ile Glu Asp Arg Asp Gln Leu Asp Ser Trp Leu Tyr 
65                  70                  75                  80  

Val Leu Leu Leu Met Ser Ala Tyr Gln Leu Arg Tyr Leu Asp Lys Ile 
                85                  90                  95      

Pro Asp His Ala Val Val Asn Glu Ala Val Glu Leu Ala Lys Leu Arg 
            100                 105                 110         

Lys Lys Gly Ser Glu Lys Leu Val Asn Ala Val Leu Arg Arg Ile Leu 
        115                 120                 125             

Arg Glu Gly Trp Pro Asp Ile Ala Ser Ile Lys Arg Lys Asn Lys Arg 
    130                 135                 140                 

Asp Ser Ile Ala Tyr Ser Leu Pro Val Trp Leu Val Ala Lys Leu Lys 
145                 150                 155                 160 

Glu Glu Tyr Gly Glu Glu Arg Ala Lys Ala Ile Phe Glu Ser Leu Leu 
                165                 170                 175     

Val Arg Asn Lys Ala Ser Ile Arg Val Thr Asp Leu Ser Arg Lys Glu 
            180                 185                 190         

Glu Ile Gln Ala Leu Leu Glu Ala Asn Asn Ser Leu Leu Ala Thr Thr 
        195                 200                 205             

Gly Leu Val Lys Glu Gln Gly His Phe Ala Gly His Asn Leu Phe Ala 
    210                 215                 220                 

Asp Gly Ala Ile Thr Ile Gln Asp Glu Ser Ser Gln Leu Val Ala Pro 
225                 230                 235                 240 

Thr Leu Asp Leu Gln Gly Asp Glu Arg Val Leu Asp Ala Cys Ala Ala 
                245                 250                 255     

Pro Gly Gly Lys Thr Ala His Ile Ala Ser Tyr Leu Thr Thr Gly Gln 
            260                 265                 270         

Val Thr Ala Leu Asp Leu Tyr Asp His Lys Leu Asp Leu Ile Gln Glu 
        275                 280                 285             

Asn Ala Gln Arg Leu Gly Val Glu Asp Arg Val Gln Thr Gln Lys Leu 
    290                 295                 300                 

Asp Ala Arg Lys Val His Glu Phe Phe Asp Gln Asp Ser Phe Asp Lys 
305                 310                 315                 320 

Ile Leu Val Asp Ala Pro Cys Ser Gly Ile Gly Leu Leu Arg Arg Lys 
                325                 330                 335     

Pro Asp Ile Lys Tyr Asn Lys Glu Thr Ala Asp Phe Ala Ser Leu Gln 
            340                 345                 350         

Glu Ile Gln Leu Glu Ile Leu Gly Ser Val Cys Gln Ile Leu Gly Lys 
        355                 360                 365             

Gly Gly Ile Ile Thr Tyr Ser Thr Cys Thr Ile Val Ser Glu Glu Asn 
    370                 375                 380                 

Phe Gln Val Val Lys Ala Phe Leu Glu Ser His Pro Glu Phe Glu Gln 
385                 390                 395                 400 

Val Lys Leu Glu His Glu Cys Lys Asp Ile Met Lys Asp Gly Cys Ile 
                405                 410                 415     

Leu Ile Thr Pro Glu Leu Tyr Gly Ser Asp Gly Phe Phe Ile Ser Gln 
            420                 425                 430         

Phe Arg Lys Ile Ser Asp 
        435             

<210>   3579
<211>   933
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3579
atgacaaaac taatctttat ggggaccccc gacttttcag caacagtctt aaaaggactt   60
ttgacagatg accgttacga aattctagcc gttgtgaccc agccagaccg tgctgttggt   120
cgtaaaaaag ttatccaaga aaccccagtc aagcaggctg ccaaggaagc aggactatct   180
atctaccaac ctgaaaaatt atctggaagt ccagagatgg aagatcttat gaagctagga   240
gcagatggaa ttgtgactgc tgcttttggg cagtttctcc caagcaaact ccttgatagc   300
atggactttg ctgtcaacgt tcatgcctcc ctccttccta gacaccgtgg tggtgcgcct   360
atccattatg ccttgattca aggggatgag gaagctggtg tgaccatcat ggaaatggtt   420
aaggaaatgg atgcaggaga tatgatttct cgtcgcagca ttccgatcac agatgaggac   480
aatgttggca ccttgtttga aaaattggcg ctagttggtc gtgatttgct tttggacact   540
ctgcctgcct atattgctgg tgatatcaaa cctgaaccgc aggatacgag tcaggttacc   600
ttctctccaa atataaagcc agaggaagaa aaactggact ggaacaaaac caatcgtcaa   660
ctctttaacc aaattcgtgg aatgaacccc tggcctgttg cccatacttt ccttaagggc   720
gaccgcttta agatttatga agccctacca gtagaaggtc agggaaatcc aggtgagatt   780
ctctctatcg gcaagaaaga attgattgtc gcaacggctg aaggggctct atccctcaaa   840
caagtgcagc cagctggtaa gcctaagatg gacattgctt ccttcctcaa cggagttgga   900
cgtacattga ctgtaggaga acgatttggt gac                                933

<210>   3580
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   methionyl-tRNA formyltransferase (fmt)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903622 (e-176)

<400>   3580
Met Thr Lys Leu Ile Phe Met Gly Thr Pro Asp Phe Ser Ala Thr Val 
1               5                   10                  15      

Leu Lys Gly Leu Leu Thr Asp Asp Arg Tyr Glu Ile Leu Ala Val Val 
            20                  25                  30          

Thr Gln Pro Asp Arg Ala Val Gly Arg Lys Lys Val Ile Gln Glu Thr 
        35                  40                  45              

Pro Val Lys Gln Ala Ala Lys Glu Ala Gly Leu Ser Ile Tyr Gln Pro 
    50                  55                  60                  

Glu Lys Leu Ser Gly Ser Pro Glu Met Glu Asp Leu Met Lys Leu Gly 
65                  70                  75                  80  

Ala Asp Gly Ile Val Thr Ala Ala Phe Gly Gln Phe Leu Pro Ser Lys 
                85                  90                  95      

Leu Leu Asp Ser Met Asp Phe Ala Val Asn Val His Ala Ser Leu Leu 
            100                 105                 110         

Pro Arg His Arg Gly Gly Ala Pro Ile His Tyr Ala Leu Ile Gln Gly 
        115                 120                 125             

Asp Glu Glu Ala Gly Val Thr Ile Met Glu Met Val Lys Glu Met Asp 
    130                 135                 140                 

Ala Gly Asp Met Ile Ser Arg Arg Ser Ile Pro Ile Thr Asp Glu Asp 
145                 150                 155                 160 

Asn Val Gly Thr Leu Phe Glu Lys Leu Ala Leu Val Gly Arg Asp Leu 
                165                 170                 175     

Leu Leu Asp Thr Leu Pro Ala Tyr Ile Ala Gly Asp Ile Lys Pro Glu 
            180                 185                 190         

Pro Gln Asp Thr Ser Gln Val Thr Phe Ser Pro Asn Ile Lys Pro Glu 
        195                 200                 205             

Glu Glu Lys Leu Asp Trp Asn Lys Thr Asn Arg Gln Leu Phe Asn Gln 
    210                 215                 220                 

Ile Arg Gly Met Asn Pro Trp Pro Val Ala His Thr Phe Leu Lys Gly 
225                 230                 235                 240 

Asp Arg Phe Lys Ile Tyr Glu Ala Leu Pro Val Glu Gly Gln Gly Asn 
                245                 250                 255     

Pro Gly Glu Ile Leu Ser Ile Gly Lys Lys Glu Leu Ile Val Ala Thr 
            260                 265                 270         

Ala Glu Gly Ala Leu Ser Leu Lys Gln Val Gln Pro Ala Gly Lys Pro 
        275                 280                 285             

Lys Met Asp Ile Ala Ser Phe Leu Asn Gly Val Gly Arg Thr Leu Thr 
    290                 295                 300                 

Val Gly Glu Arg Phe Gly Asp 
305                 310     

<210>   3581
<211>   2394
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3581
atggccctag ctaagattat cgtagatgtg cccttgatgc agacggacca gccctatagt   60
tacaggattc cggaggaatt tgagggaatg ctggaagttg ggatgcgggt tcatgtgcct   120
tttggtaagg gtaatcgcct gattcaaggg attgttcttg gtttgaagtc ccaatcagat   180
ggagaagaga tggagcaaga tttaaaagat attgcagagg tgctggattt ttctcctgtt   240
ctcacgccag aacaactctg gctggctgag gagttacgca aatctgtctt ctcctacaaa   300
atctctatcc tcaaggccat gcttccaggg tttctgaatt ctagctatga caagattctc   360
tatcctctgg aaggcttgag tcaggaagaa cgagtgcgcc tgtttggttc agaagattcg   420
ctagcctttt cttcactaga ccttgccaag caagctgaaa tgatgcgttt gactagaaaa   480
ggcctgcttg gtctggaata tcaggcagtc gatcaaaaga aggtcaagac ccagtcttgg   540
tatgaggttg accatgctca attagaaggt gttgagattt ctacacgtgc caagaaaaag   600
ttggaactga gagattatct gctgtctcat ccagagagcg cttccttggc tagcttgtta   660
gagtcctact cgcgagagca agtcaacttc tttgtggatc aaggtgctgt taccatagtc   720
caaaaggaag ttcaacgctc ggctgcttat tttgaaggaa ttgaagcaag tagacctttg   780
gagttaaatc cagaacaaag acaggcgcgt gatgcggttg tgagttctat tggcagttct   840
caacctccct ttctacttca agggattaca ggaagtggga agaccgaggt ttacttgcag   900
attatccaag gtgccctgga taagggcaag acagctattt tgctggtacc tgagatttcc   960
ttgactcctc agatgaccga gcgttttata gcacgttttg gggacaaggt agccattctt   1020
cactcaggat tatccaatgg tgaaaagtat gatgaatggc gcaaggtgga gcgtggcgat   1080
gcccaagttg ttgttggtgc cagatctgct atctttgctc ctctgaaaaa tctgggtgtc   1140
atgattattg atgaagagca tgaagcggct tataagcagg acagcaatcc ccgttaccat   1200
gccagagagg tagctatttt acgggctcag tataatcaag caactctggt acttggatct   1260
gcaacgccga gcttagagag ccgggcacgt gctggcaaag gcgtctatca acacttacgt   1320
ctaacccaac gtgccaatcc tttggctaca atccctgagg ttcaagtgat tgactttcga   1380
gactatatcg gacaaaatga gacgtcaaac tttacgcctc ctttgctaga ggctatccaa   1440
gaccgtctgg ttaaaaaaga gcaggtggtt ctcatgctca atcgccgtgg ttattctagc   1500
tttgtcatgt gtcgggagtg tgggacggtg gatacttgtc ccaactgcga tatttctctg   1560
accttgcata tggataccaa gactatgaac tgccattatt gtggtttctc gaaggatatt   1620
cctcaggtct gtcctaactg taagagccgc agtattcgtt actatgggac gggaactcag   1680
aaggcttatg atgagctagc agaactcttt ccccaagctc gcattctgag gatggatgtg   1740
gatacgactc gaaagaaagg cagtcaccaa gccttgcttg accagtttgg gcgaggggaa   1800
gcggatattt tacttggtac tcagatgatt gcaaagggtt tggattttcc caatgttacc   1860
ctagtcggag ttctaaatgc ggatacggcc ttgaatctgc ctgatttccg ttcttctgag   1920
agaaccttcc agctcttgac tcaggtggca ggtcgatcag gtcgggctga aaaggcaggt   1980
caagtcttga tacagtccta caatccgcag cactatgcta ttcgatttgc caaggatcaa   2040
gattacgaag gcttttatgc ctatgaaatg ggaatcagac gacaactcgg ctatccacct   2100
tactatttca cgattggtat taccctttct cacaagaaag aagaagaggt tttcaaacgt   2160
gcctatgaag tcatgaacat tttgcggtca ggcttgtcag agaccagtcc cattctgggg   2220
ccaacgccaa aaccgattgc ccgtacccac aacctctatc attaccagat tttaattaaa   2280
taccgtttag aagatgagct ggggtcgacc ctcaaccagg ttttagcctt gactcaagaa   2340
cgggaaaata gtgagctccg tctcagcatt gaccatgagc cgcagcaatt ttta         2394

<210>   3582
<211>   798
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   primosomal protein N' (priA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903623 (0.E+01)

<400>   3582
Met Ala Leu Ala Lys Ile Ile Val Asp Val Pro Leu Met Gln Thr Asp 
1               5                   10                  15      

Gln Pro Tyr Ser Tyr Arg Ile Pro Glu Glu Phe Glu Gly Met Leu Glu 
            20                  25                  30          

Val Gly Met Arg Val His Val Pro Phe Gly Lys Gly Asn Arg Leu Ile 
        35                  40                  45              

Gln Gly Ile Val Leu Gly Leu Lys Ser Gln Ser Asp Gly Glu Glu Met 
    50                  55                  60                  

Glu Gln Asp Leu Lys Asp Ile Ala Glu Val Leu Asp Phe Ser Pro Val 
65                  70                  75                  80  

Leu Thr Pro Glu Gln Leu Trp Leu Ala Glu Glu Leu Arg Lys Ser Val 
                85                  90                  95      

Phe Ser Tyr Lys Ile Ser Ile Leu Lys Ala Met Leu Pro Gly Phe Leu 
            100                 105                 110         

Asn Ser Ser Tyr Asp Lys Ile Leu Tyr Pro Leu Glu Gly Leu Ser Gln 
        115                 120                 125             

Glu Glu Arg Val Arg Leu Phe Gly Ser Glu Asp Ser Leu Ala Phe Ser 
    130                 135                 140                 

Ser Leu Asp Leu Ala Lys Gln Ala Glu Met Met Arg Leu Thr Arg Lys 
145                 150                 155                 160 

Gly Leu Leu Gly Leu Glu Tyr Gln Ala Val Asp Gln Lys Lys Val Lys 
                165                 170                 175     

Thr Gln Ser Trp Tyr Glu Val Asp His Ala Gln Leu Glu Gly Val Glu 
            180                 185                 190         

Ile Ser Thr Arg Ala Lys Lys Lys Leu Glu Leu Arg Asp Tyr Leu Leu 
        195                 200                 205             

Ser His Pro Glu Ser Ala Ser Leu Ala Ser Leu Leu Glu Ser Tyr Ser 
    210                 215                 220                 

Arg Glu Gln Val Asn Phe Phe Val Asp Gln Gly Ala Val Thr Ile Val 
225                 230                 235                 240 

Gln Lys Glu Val Gln Arg Ser Ala Ala Tyr Phe Glu Gly Ile Glu Ala 
                245                 250                 255     

Ser Arg Pro Leu Glu Leu Asn Pro Glu Gln Arg Gln Ala Arg Asp Ala 
            260                 265                 270         

Val Val Ser Ser Ile Gly Ser Ser Gln Pro Pro Phe Leu Leu Gln Gly 
        275                 280                 285             

Ile Thr Gly Ser Gly Lys Thr Glu Val Tyr Leu Gln Ile Ile Gln Gly 
    290                 295                 300                 

Ala Leu Asp Lys Gly Lys Thr Ala Ile Leu Leu Val Pro Glu Ile Ser 
305                 310                 315                 320 

Leu Thr Pro Gln Met Thr Glu Arg Phe Ile Ala Arg Phe Gly Asp Lys 
                325                 330                 335     

Val Ala Ile Leu His Ser Gly Leu Ser Asn Gly Glu Lys Tyr Asp Glu 
            340                 345                 350         

Trp Arg Lys Val Glu Arg Gly Asp Ala Gln Val Val Val Gly Ala Arg 
        355                 360                 365             

Ser Ala Ile Phe Ala Pro Leu Lys Asn Leu Gly Val Met Ile Ile Asp 
    370                 375                 380                 

Glu Glu His Glu Ala Ala Tyr Lys Gln Asp Ser Asn Pro Arg Tyr His 
385                 390                 395                 400 

Ala Arg Glu Val Ala Ile Leu Arg Ala Gln Tyr Asn Gln Ala Thr Leu 
                405                 410                 415     

Val Leu Gly Ser Ala Thr Pro Ser Leu Glu Ser Arg Ala Arg Ala Gly 
            420                 425                 430         

Lys Gly Val Tyr Gln His Leu Arg Leu Thr Gln Arg Ala Asn Pro Leu 
        435                 440                 445             

Ala Thr Ile Pro Glu Val Gln Val Ile Asp Phe Arg Asp Tyr Ile Gly 
    450                 455                 460                 

Gln Asn Glu Thr Ser Asn Phe Thr Pro Pro Leu Leu Glu Ala Ile Gln 
465                 470                 475                 480 

Asp Arg Leu Val Lys Lys Glu Gln Val Val Leu Met Leu Asn Arg Arg 
                485                 490                 495     

Gly Tyr Ser Ser Phe Val Met Cys Arg Glu Cys Gly Thr Val Asp Thr 
            500                 505                 510         

Cys Pro Asn Cys Asp Ile Ser Leu Thr Leu His Met Asp Thr Lys Thr 
        515                 520                 525             

Met Asn Cys His Tyr Cys Gly Phe Ser Lys Asp Ile Pro Gln Val Cys 
    530                 535                 540                 

Pro Asn Cys Lys Ser Arg Ser Ile Arg Tyr Tyr Gly Thr Gly Thr Gln 
545                 550                 555                 560 

Lys Ala Tyr Asp Glu Leu Ala Glu Leu Phe Pro Gln Ala Arg Ile Leu 
                565                 570                 575     

Arg Met Asp Val Asp Thr Thr Arg Lys Lys Gly Ser His Gln Ala Leu 
            580                 585                 590         

Leu Asp Gln Phe Gly Arg Gly Glu Ala Asp Ile Leu Leu Gly Thr Gln 
        595                 600                 605             

Met Ile Ala Lys Gly Leu Asp Phe Pro Asn Val Thr Leu Val Gly Val 
    610                 615                 620                 

Leu Asn Ala Asp Thr Ala Leu Asn Leu Pro Asp Phe Arg Ser Ser Glu 
625                 630                 635                 640 

Arg Thr Phe Gln Leu Leu Thr Gln Val Ala Gly Arg Ser Gly Arg Ala 
                645                 650                 655     

Glu Lys Ala Gly Gln Val Leu Ile Gln Ser Tyr Asn Pro Gln His Tyr 
            660                 665                 670         

Ala Ile Arg Phe Ala Lys Asp Gln Asp Tyr Glu Gly Phe Tyr Ala Tyr 
        675                 680                 685             

Glu Met Gly Ile Arg Arg Gln Leu Gly Tyr Pro Pro Tyr Tyr Phe Thr 
    690                 695                 700                 

Ile Gly Ile Thr Leu Ser His Lys Lys Glu Glu Glu Val Phe Lys Arg 
705                 710                 715                 720 

Ala Tyr Glu Val Met Asn Ile Leu Arg Ser Gly Leu Ser Glu Thr Ser 
                725                 730                 735     

Pro Ile Leu Gly Pro Thr Pro Lys Pro Ile Ala Arg Thr His Asn Leu 
            740                 745                 750         

Tyr His Tyr Gln Ile Leu Ile Lys Tyr Arg Leu Glu Asp Glu Leu Gly 
        755                 760                 765             

Ser Thr Leu Asn Gln Val Leu Ala Leu Thr Gln Glu Arg Glu Asn Ser 
    770                 775                 780                 

Glu Leu Arg Leu Ser Ile Asp His Glu Pro Gln Gln Phe Leu 
785                 790                 795             

<210>   3583
<211>   309
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3583
atgttaaaac cctctattga taccttgctc gacaaggttc cttcaaaata ttcactcgta   60
atcttggaag caaaacgtgc ccacgaattg gaagcaggtg ccccagcaac tcaaggtttc   120
aagtctgaaa aatcaactct tcgcgcttta gaagaaatcg aatcaggaaa cgttacaatt   180
cacccagatc cagaaggaaa acgtgaagca gtgcgtcgcc gtatcgaaga agaaaaacgc   240
cgcaaagaag aagaagaaaa gaaaatcaaa gagcaaattg ctaaagaaaa agaagatggt   300
gaaaaaatt                                                           309

<210>   3584
<211>   103
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-directed RNA polymerase, omega subunit, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903624 (9.E-54)

<400>   3584
Met Leu Lys Pro Ser Ile Asp Thr Leu Leu Asp Lys Val Pro Ser Lys 
1               5                   10                  15      

Tyr Ser Leu Val Ile Leu Glu Ala Lys Arg Ala His Glu Leu Glu Ala 
            20                  25                  30          

Gly Ala Pro Ala Thr Gln Gly Phe Lys Ser Glu Lys Ser Thr Leu Arg 
        35                  40                  45              

Ala Leu Glu Glu Ile Glu Ser Gly Asn Val Thr Ile His Pro Asp Pro 
    50                  55                  60                  

Glu Gly Lys Arg Glu Ala Val Arg Arg Arg Ile Glu Glu Glu Lys Arg 
65                  70                  75                  80  

Arg Lys Glu Glu Glu Glu Lys Lys Ile Lys Glu Gln Ile Ala Lys Glu 
                85                  90                  95      

Lys Glu Asp Gly Glu Lys Ile 
            100             

<210>   3585
<211>   624
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   3585
atggcagacc gaggcttact aatcgttttt tctggtcctt caggggttgg aaaaggaacg   60
gttagaagag agatttttga gagttctgaa aaccaatttc aatattctgt atcgatgacg   120
acacgcgcac aacgtcctgg agaagtggac ggtgttgact atttcttccg tactcgtgaa   180
gaatttgaag agctgattcg tcaaggacag atgttggaat acgcagaata tgtcggtaac   240
tactatggaa ctcctctgac ctatgtcaat gaaaccttgg acaagggaat cgatgttttc   300
cttgaaattg aagttcaggg tgctcttcag gtcaagaaaa aggttccaga tgctgtcttt   360
atcttcctga caccaccaga tttggatgaa ttgcaagatc gcttggtagg tcgtggaaca   420
gatagtgcag aagtgattgc ccaacgaatc gaaaaggcca aggaagaaat tgccctcatg   480
cgtgagtatg attatgcgat tgtcaacgat caggtacccc tagctgctga acgtgtcaaa   540
tgtgtgattg aagcagaaca cttctgtgtg gatcgtgtca ttggtcacta tcaggagatg   600
ttaccaaaat ctccaactac ccga                                          624

<210>   3586
<211>   208
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   guanylate kinase (gmk)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903625 (e-117)

<400>   3586
Met Ala Asp Arg Gly Leu Leu Ile Val Phe Ser Gly Pro Ser Gly Val 
1               5                   10                  15      

Gly Lys Gly Thr Val Arg Arg Glu Ile Phe Glu Ser Ser Glu Asn Gln 
            20                  25                  30          

Phe Gln Tyr Ser Val Ser Met Thr Thr Arg Ala Gln Arg Pro Gly Glu 
        35                  40                  45              

Val Asp Gly Val Asp Tyr Phe Phe Arg Thr Arg Glu Glu Phe Glu Glu 
    50                  55                  60                  

Leu Ile Arg Gln Gly Gln Met Leu Glu Tyr Ala Glu Tyr Val Gly Asn 
65                  70                  75                  80  

Tyr Tyr Gly Thr Pro Leu Thr Tyr Val Asn Glu Thr Leu Asp Lys Gly 
                85                  90                  95      

Ile Asp Val Phe Leu Glu Ile Glu Val Gln Gly Ala Leu Gln Val Lys 
            100                 105                 110         

Lys Lys Val Pro Asp Ala Val Phe Ile Phe Leu Thr Pro Pro Asp Leu 
        115                 120                 125             

Asp Glu Leu Gln Asp Arg Leu Val Gly Arg Gly Thr Asp Ser Ala Glu 
    130                 135                 140                 

Val Ile Ala Gln Arg Ile Glu Lys Ala Lys Glu Glu Ile Ala Leu Met 
145                 150                 155                 160 

Arg Glu Tyr Asp Tyr Ala Ile Val Asn Asp Gln Val Pro Leu Ala Ala 
                165                 170                 175     

Glu Arg Val Lys Cys Val Ile Glu Ala Glu His Phe Cys Val Asp Arg 
            180                 185                 190         

Val Ile Gly His Tyr Gln Glu Met Leu Pro Lys Ser Pro Thr Thr Arg 
        195                 200                 205             


<210>   3587
<211>   1611
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3587
atggaaatca tgtcgcttgc gattgctgtt tttgccgtca tcattggttt agtcattgga   60
tatgtcagca tctcagctaa gatgaaatca tctcaggaag ctgcagagtt gatgctttta   120
aatgctgaac aagaagcaac taatttacgt ggacaagctg agcgtgaagc ggatttactt   180
gttaatgaag ccaaacgtga aagcaagtct cttaaaaaag aagcactatt ggaggccaaa   240
gaagaagcca gaaaataccg tgaagaagtg gacgctgaat tcaaatcaga acgtcaagaa   300
ctcaaacaaa tcgaaagtcg tttgacagag agagctacta gccttgaccg taaggacgac   360
aatttgacga gtaaagaaca aacacttgaa caaaaagaac aaagtatttc tgatagagcg   420
aaaaaccttg atgcgcgtga agagcaatta gaggaagtcg aaagacaaaa agaagcagaa   480
ctagagcgta ttggtgcgct gtctcaggca gaagcacgag atattatctt ggctcagaca   540
gaggaaaact tgaccaggga gattgccagt cgcattcgcg aagctgagca agaggtcaag   600
gaacgttctg acaaaatggc caaggacatc ttggttcaag ctatgcaacg tatcgctggt   660
gaatatgtag cggagtcaac aaactcaaca gttcatctgc cagacgatac tatgaaggga   720
cgcattattg gtcgtgaagg tcgtaacatt cgtacctttg aaagtttgac aggggtcgat   780
gtgattatcg acgatacacc agaagtggtg accttgtcag gatttgatcc gattcgtcgt   840
gagattgccc gtatgactat ggaaatgttg ctcaaagatg gtcgtataca tccagctcgt   900
atcgaagagt tggttgagaa aaaccgtcaa gagattgaca ataagattcg tgaatacggt   960
gaggctgctg cctatgaaat tggtgcgcca aaccttcatc cagacttgat gaagattatg   1020
ggacgtttgc agttccgtac ttcatatgga caaaatgttt tgcgccattc gattgaggtt   1080
gctaagttgg ctggtatcat ggcgagcgaa cttggtgaaa atgcggctct tgcccgtcgt   1140
gctggattcc ttcacgatat cgggaaagcc attgaccatg aggttgaagg tagccacgtt   1200
gaaatcggta tggaattggc ccgtaagtac aaggaacccc cagttgtggt gaatacgatt   1260
gctagtcacc acggagatgt tgaagctgag agcgtgatag cagttatcgt cgctgcagca   1320
gatgccttga gcgcagcccg tccaggtgct cgtagtgagt ctcttgaaag ctacatcaag   1380
cgtctccatg atttggaaga aattgctaac ggctttgaag gagtgcaaac tagctttgcc   1440
cttcaagcag gacgtgaaat tcgtatcatg gtcaatccag gaaaaatcaa ggacgacaaa   1500
gtcacaatct tggctcacaa agttcgtaag aaaattgaaa acaatctcga ttatccagga   1560
aatatcaagg taaccgtgat tcgcgagctt cgtgcagtag attatgctaa a            1611

<210>   3588
<211>   537
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   KH domain protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903626 (0.E+01)

<400>   3588
Met Glu Ile Met Ser Leu Ala Ile Ala Val Phe Ala Val Ile Ile Gly 
1               5                   10                  15      

Leu Val Ile Gly Tyr Val Ser Ile Ser Ala Lys Met Lys Ser Ser Gln 
            20                  25                  30          

Glu Ala Ala Glu Leu Met Leu Leu Asn Ala Glu Gln Glu Ala Thr Asn 
        35                  40                  45              

Leu Arg Gly Gln Ala Glu Arg Glu Ala Asp Leu Leu Val Asn Glu Ala 
    50                  55                  60                  

Lys Arg Glu Ser Lys Ser Leu Lys Lys Glu Ala Leu Leu Glu Ala Lys 
65                  70                  75                  80  

Glu Glu Ala Arg Lys Tyr Arg Glu Glu Val Asp Ala Glu Phe Lys Ser 
                85                  90                  95      

Glu Arg Gln Glu Leu Lys Gln Ile Glu Ser Arg Leu Thr Glu Arg Ala 
            100                 105                 110         

Thr Ser Leu Asp Arg Lys Asp Asp Asn Leu Thr Ser Lys Glu Gln Thr 
        115                 120                 125             

Leu Glu Gln Lys Glu Gln Ser Ile Ser Asp Arg Ala Lys Asn Leu Asp 
    130                 135                 140                 

Ala Arg Glu Glu Gln Leu Glu Glu Val Glu Arg Gln Lys Glu Ala Glu 
145                 150                 155                 160 

Leu Glu Arg Ile Gly Ala Leu Ser Gln Ala Glu Ala Arg Asp Ile Ile 
                165                 170                 175     

Leu Ala Gln Thr Glu Glu Asn Leu Thr Arg Glu Ile Ala Ser Arg Ile 
            180                 185                 190         

Arg Glu Ala Glu Gln Glu Val Lys Glu Arg Ser Asp Lys Met Ala Lys 
        195                 200                 205             

Asp Ile Leu Val Gln Ala Met Gln Arg Ile Ala Gly Glu Tyr Val Ala 
    210                 215                 220                 

Glu Ser Thr Asn Ser Thr Val His Leu Pro Asp Asp Thr Met Lys Gly 
225                 230                 235                 240 

Arg Ile Ile Gly Arg Glu Gly Arg Asn Ile Arg Thr Phe Glu Ser Leu 
                245                 250                 255     

Thr Gly Val Asp Val Ile Ile Asp Asp Thr Pro Glu Val Val Thr Leu 
            260                 265                 270         

Ser Gly Phe Asp Pro Ile Arg Arg Glu Ile Ala Arg Met Thr Met Glu 
        275                 280                 285             

Met Leu Leu Lys Asp Gly Arg Ile His Pro Ala Arg Ile Glu Glu Leu 
    290                 295                 300                 

Val Glu Lys Asn Arg Gln Glu Ile Asp Asn Lys Ile Arg Glu Tyr Gly 
305                 310                 315                 320 

Glu Ala Ala Ala Tyr Glu Ile Gly Ala Pro Asn Leu His Pro Asp Leu 
                325                 330                 335     

Met Lys Ile Met Gly Arg Leu Gln Phe Arg Thr Ser Tyr Gly Gln Asn 
            340                 345                 350         

Val Leu Arg His Ser Ile Glu Val Ala Lys Leu Ala Gly Ile Met Ala 
        355                 360                 365             

Ser Glu Leu Gly Glu Asn Ala Ala Leu Ala Arg Arg Ala Gly Phe Leu 
    370                 375                 380                 

His Asp Ile Gly Lys Ala Ile Asp His Glu Val Glu Gly Ser His Val 
385                 390                 395                 400 

Glu Ile Gly Met Glu Leu Ala Arg Lys Tyr Lys Glu Pro Pro Val Val 
                405                 410                 415     

Val Asn Thr Ile Ala Ser His His Gly Asp Val Glu Ala Glu Ser Val 
            420                 425                 430         

Ile Ala Val Ile Val Ala Ala Ala Asp Ala Leu Ser Ala Ala Arg Pro 
        435                 440                 445             

Gly Ala Arg Ser Glu Ser Leu Glu Ser Tyr Ile Lys Arg Leu His Asp 
    450                 455                 460                 

Leu Glu Glu Ile Ala Asn Gly Phe Glu Gly Val Gln Thr Ser Phe Ala 
465                 470                 475                 480 

Leu Gln Ala Gly Arg Glu Ile Arg Ile Met Val Asn Pro Gly Lys Ile 
                485                 490                 495     

Lys Asp Asp Lys Val Thr Ile Leu Ala His Lys Val Arg Lys Lys Ile 
            500                 505                 510         

Glu Asn Asn Leu Asp Tyr Pro Gly Asn Ile Lys Val Thr Val Ile Arg 
        515                 520                 525             

Glu Leu Arg Ala Val Asp Tyr Ala Lys 
    530                 535         

<210>   3589
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3589
atgctgctca agtttacaga agatgcctgg gcagattatt gctactggca aaatcaggat   60
aagaaaacgt taaaaagaat caataaacta atcaaggata ttcaacgtga tccctttaca   120
ggaataggta aaccagaacc actcaaatat gattaccaag gagcctggtc acggcgtatt   180
gatgcagaaa atcgcttgat ttatatgatg gatggagata gcgtggcttt cttgtccttt   240
aaagatcatt ac                                                       252

<210>   3590
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903627 (3.E-48)

<400>   3590
Met Leu Leu Lys Phe Thr Glu Asp Ala Trp Ala Asp Tyr Cys Tyr Trp 
1               5                   10                  15      

Gln Asn Gln Asp Lys Lys Thr Leu Lys Arg Ile Asn Lys Leu Ile Lys 
            20                  25                  30          

Asp Ile Gln Arg Asp Pro Phe Thr Gly Ile Gly Lys Pro Glu Pro Leu 
        35                  40                  45              

Lys Tyr Asp Tyr Gln Gly Ala Trp Ser Arg Arg Ile Asp Ala Glu Asn 
    50                  55                  60                  

Arg Leu Ile Tyr Met Met Asp Gly Asp Ser Val Ala Phe Leu Ser Phe 
65                  70                  75                  80  

Lys Asp His Tyr 
                

<210>   3591
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3591
gtggtcaata aaaatccaga tgaggacatt gtagtccttt caaagagtga gtgggatagt   60
atccaagaaa ccctgagaat tgctcaaaat aaggaacttt ctgataaggt tttgcgagga   120
atggctcaag ttcgtgctgg aagtactcag gtccatgtta ttgaggag                168

<210>   3592
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903628 (6.E-44)

<400>   3592
Met Val Asn Lys Asn Pro Asp Glu Asp Ile Val Val Leu Ser Lys Ser 
1               5                   10                  15      

Glu Trp Asp Ser Ile Gln Glu Thr Leu Arg Ile Ala Gln Asn Lys Glu 
            20                  25                  30          

Leu Ser Asp Lys Val Leu Arg Gly Met Ala Gln Val Arg Ala Gly Ser 
        35                  40                  45              

Thr Gln Val His Val Ile Glu Glu 
    50                  55      

<210>   3593
<211>   1095
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3593
atgaccataa caggtattat cgcggagttc aatccttttc ataatggcca taaatacctg   60
ctggatcagg cagagggact gaaaattgtt gccatgtcag ggaatttcat gcagcgtgga   120
gagcctgcta ttgtggataa gtggacaagg acccagatgg cgctggaaaa tggcgcagac   180
ttggtagtgg aattgccctt tttagtcagt gttcaggcag ctgatttctt tggtcaagga   240
gctatggata tcttggatcg cttgggcatt gatagtctag tttttgggac agaggaagtt   300
cgagattatc agaaaattgc tgacttatac acagagaaag gtgctgagat ggagaaattt   360
gtggaaaatc tgcctgattc cctttcctat ccccagaaaa cccaagctat gtggaaggaa   420
tttgctggtc ttgatttttc aggtaatacc cccaatcatg ttcttgctct ggcctatgcc   480
aaggcggttg caggacggaa tatcaagctg catccgattc agcgtcaggg ggcaggttac   540
cattctgtga ataaagatgt ggactttgcc tcggcgacag ccctccgtca acatcagaag   600
gaccaagatt tcttagaacg ttttatgcct tctgttgccc tatttgagca ggccagtaag   660
gtgatctggg aagactattt tcccttgctc cgctatcaaa tcttgtcaaa tcccgaccta   720
accaccatct atcaggtcaa tcaagaaatg gctgtgcgca ttaaagaagc tattaaaaca   780
gcccagtctg tggaagaatt ggtcgagtta gtgactacca aacgttacac caaggcgcgt   840
gtcagacgcc tattgaccta tattttgatg caggctagag aaagtgactt gccagaagcc   900
attcatgtcc ttggatttac tgaaaaaggt aggcaacatc tcaagtcttt gaaaggtcag   960
gtcagtctag tcagccgaat tggcaaagaa ccttgggatg ctatgaccca aaaagcagac   1020
cagatttacc aactagggaa gccaagtata gcagagcaaa attttggaag agtgccgatt   1080
agaatagaaa caaac                                                    1095

<210>   3594
<211>   365
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903629 (0.E+01)

<400>   3594
Met Thr Ile Thr Gly Ile Ile Ala Glu Phe Asn Pro Phe His Asn Gly 
1               5                   10                  15      

His Lys Tyr Leu Leu Asp Gln Ala Glu Gly Leu Lys Ile Val Ala Met 
            20                  25                  30          

Ser Gly Asn Phe Met Gln Arg Gly Glu Pro Ala Ile Val Asp Lys Trp 
        35                  40                  45              

Thr Arg Thr Gln Met Ala Leu Glu Asn Gly Ala Asp Leu Val Val Glu 
    50                  55                  60                  

Leu Pro Phe Leu Val Ser Val Gln Ala Ala Asp Phe Phe Gly Gln Gly 
65                  70                  75                  80  

Ala Met Asp Ile Leu Asp Arg Leu Gly Ile Asp Ser Leu Val Phe Gly 
                85                  90                  95      

Thr Glu Glu Val Arg Asp Tyr Gln Lys Ile Ala Asp Leu Tyr Thr Glu 
            100                 105                 110         

Lys Gly Ala Glu Met Glu Lys Phe Val Glu Asn Leu Pro Asp Ser Leu 
        115                 120                 125             

Ser Tyr Pro Gln Lys Thr Gln Ala Met Trp Lys Glu Phe Ala Gly Leu 
    130                 135                 140                 

Asp Phe Ser Gly Asn Thr Pro Asn His Val Leu Ala Leu Ala Tyr Ala 
145                 150                 155                 160 

Lys Ala Val Ala Gly Arg Asn Ile Lys Leu His Pro Ile Gln Arg Gln 
                165                 170                 175     

Gly Ala Gly Tyr His Ser Val Asn Lys Asp Val Asp Phe Ala Ser Ala 
            180                 185                 190         

Thr Ala Leu Arg Gln His Gln Lys Asp Gln Asp Phe Leu Glu Arg Phe 
        195                 200                 205             

Met Pro Ser Val Ala Leu Phe Glu Gln Ala Ser Lys Val Ile Trp Glu 
    210                 215                 220                 

Asp Tyr Phe Pro Leu Leu Arg Tyr Gln Ile Leu Ser Asn Pro Asp Leu 
225                 230                 235                 240 

Thr Thr Ile Tyr Gln Val Asn Gln Glu Met Ala Val Arg Ile Lys Glu 
                245                 250                 255     

Ala Ile Lys Thr Ala Gln Ser Val Glu Glu Leu Val Glu Leu Val Thr 
            260                 265                 270         

Thr Lys Arg Tyr Thr Lys Ala Arg Val Arg Arg Leu Leu Thr Tyr Ile 
        275                 280                 285             

Leu Met Gln Ala Arg Glu Ser Asp Leu Pro Glu Ala Ile His Val Leu 
    290                 295                 300                 

Gly Phe Thr Glu Lys Gly Arg Gln His Leu Lys Ser Leu Lys Gly Gln 
305                 310                 315                 320 

Val Ser Leu Val Ser Arg Ile Gly Lys Glu Pro Trp Asp Ala Met Thr 
                325                 330                 335     

Gln Lys Ala Asp Gln Ile Tyr Gln Leu Gly Lys Pro Ser Ile Ala Glu 
            340                 345                 350         

Gln Asn Phe Gly Arg Val Pro Ile Arg Ile Glu Thr Asn 
        355                 360                 365 

<210>   3595
<211>   744
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3595
atgattatgg cgacttatga aacctttgcg gcggtctatg atgcggtcat ggacgatagt   60
ttatacgaca aatggacgaa tttttctctg cgtcatttgc ctaagaccaa ggagagaaag   120
aaactcttgg aattggcttg tgggacagga attcaatcag tgcgcttctc tcaggctggt   180
tttgatgtga ctggacttga cttgagtgcg gatatgttga agattgcgga gaagagagca   240
acttcagcca agcaaaagat tgcttttata gaaggtaata tgctgaattt gtccaaggca   300
gggaaatacg attttgtcac gtgttattcg gactctatct gctatatgca ggatgaggtg   360
gaagtagggg acgtctttaa ggacgtgtac aatgcgctga atgaagaggg agttttcatc   420

tttgacgtgc actcgaccta ccagacagat gaagtattcc ctggctattc ctaccatgaa   480
aatgcggaag attttgccat gctttgggat acatatgagg acgaagttcc tcactccatc   540
gtgcatgagc tgactttctt tatcaaggag gctgacggtt cctttagtcg ccacgatgaa   600
gtacatgagg agaggaccta tgagatcttg acctatgata tcttgctgga acaggctgga   660
tttaagtcct tcaaactcta tgcagacttt gaggataagg agccaacaga aactagcacc   720
cgttggtttt ttgtggcgca gaag                                          744

<210>   3596
<211>   248
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903630 (e-145)

<400>   3596
Met Ile Met Ala Thr Tyr Glu Thr Phe Ala Ala Val Tyr Asp Ala Val 
1               5                   10                  15      

Met Asp Asp Ser Leu Tyr Asp Lys Trp Thr Asn Phe Ser Leu Arg His 
            20                  25                  30          

Leu Pro Lys Thr Lys Glu Arg Lys Lys Leu Leu Glu Leu Ala Cys Gly 
        35                  40                  45              

Thr Gly Ile Gln Ser Val Arg Phe Ser Gln Ala Gly Phe Asp Val Thr 
    50                  55                  60                  

Gly Leu Asp Leu Ser Ala Asp Met Leu Lys Ile Ala Glu Lys Arg Ala 
65                  70                  75                  80  

Thr Ser Ala Lys Gln Lys Ile Ala Phe Ile Glu Gly Asn Met Leu Asn 
                85                  90                  95      

Leu Ser Lys Ala Gly Lys Tyr Asp Phe Val Thr Cys Tyr Ser Asp Ser 
            100                 105                 110         

Ile Cys Tyr Met Gln Asp Glu Val Glu Val Gly Asp Val Phe Lys Asp 
        115                 120                 125             

Val Tyr Asn Ala Leu Asn Glu Glu Gly Val Phe Ile Phe Asp Val His 
    130                 135                 140                 

Ser Thr Tyr Gln Thr Asp Glu Val Phe Pro Gly Tyr Ser Tyr His Glu 
145                 150                 155                 160 

Asn Ala Glu Asp Phe Ala Met Leu Trp Asp Thr Tyr Glu Asp Glu Val 
                165                 170                 175     

Pro His Ser Ile Val His Glu Leu Thr Phe Phe Ile Lys Glu Ala Asp 
            180                 185                 190         

Gly Ser Phe Ser Arg His Asp Glu Val His Glu Glu Arg Thr Tyr Glu 
        195                 200                 205             

Ile Leu Thr Tyr Asp Ile Leu Leu Glu Gln Ala Gly Phe Lys Ser Phe 
    210                 215                 220                 

Lys Leu Tyr Ala Asp Phe Glu Asp Lys Glu Pro Thr Glu Thr Ser Thr 
225                 230                 235                 240 

Arg Trp Phe Phe Val Ala Gln Lys 
                245             

<210>   3597
<211>   351
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3597
atgaacgaaa aagaattact agaactagtc gtgaaagcgg ctgatgagaa acgtgcggag   60
gatatcctcg cacttgatgt acaagatttg actagtgtga cggactactt ggtcatcact   120
agctcaatga atagccgtca gttggacgct atcgcagcta atatccgtga aaaagtagct   180
caagcaggct ttaaaggtag ccatgtcgaa ggcgatgcag ctggaggctg ggtcttactg   240
gacctcggtg ctgttgtcgt gcatatcttt tcagaagaaa tgcgtgccca ttataatcta   300
gagaagctat ggcatgaggc gaattcagta gatatttcag aagctcttgc t            351

<210>   3598
<211>   117
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iojap-related protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903631 (3.E-61)

<400>   3598
Met Asn Glu Lys Glu Leu Leu Glu Leu Val Val Lys Ala Ala Asp Glu 
1               5                   10                  15      

Lys Arg Ala Glu Asp Ile Leu Ala Leu Asp Val Gln Asp Leu Thr Ser 
            20                  25                  30          


Val Thr Asp Tyr Leu Val Ile Thr Ser Ser Met Asn Ser Arg Gln Leu 
        35                  40                  45              

Asp Ala Ile Ala Ala Asn Ile Arg Glu Lys Val Ala Gln Ala Gly Phe 
    50                  55                  60                  

Lys Gly Ser His Val Glu Gly Asp Ala Ala Gly Gly Trp Val Leu Leu 
65                  70                  75                  80  

Asp Leu Gly Ala Val Val Val His Ile Phe Ser Glu Glu Met Arg Ala 
                85                  90                  95      

His Tyr Asn Leu Glu Lys Leu Trp His Glu Ala Asn Ser Val Asp Ile 
            100                 105                 110         

Ser Glu Ala Leu Ala 
        115         

<210>   3599
<211>   498
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3599
atgaagacgg cttttataat cattgatgtt cagaatgttt tagtagaaac tgggttccag   60
acaaaaagtc tattggaaaa aatttcttat ttacaaaacc aggctagaag caagaatatt   120
gaaattatct atgttcaaca tattgagaac tctgaagctc aaacatcaga agattggcag   180
ttatctgcgc ttttaaatcg aaaacctgct gaaaaggtct ttcagaagaa gtataacagt   240
attttcaaag aaactggctt aaaagaatac ttggataagc aggggattga aaaattagtt   300
ttatgtggta tgcagacaga atattgtgtg gatacctctg tcaaggttgc ctttgaatat   360
ggctatcagc ttattgttcc agaaggtgct gtcacaacct ttgatgggga tgacattcca   420
gcagaaacga ttaatgaatt ttatgaggac atttgggagg agcgctttgc agatgttcta   480
gattacaaac atattttc                                                 498

<210>   3600
<211>   166
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   isochorismatase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903632 (9.E-93)

<400>   3600
Met Lys Thr Ala Phe Ile Ile Ile Asp Val Gln Asn Val Leu Val Glu 
1               5                   10                  15      

Thr Gly Phe Gln Thr Lys Ser Leu Leu Glu Lys Ile Ser Tyr Leu Gln 
            20                  25                  30          

Asn Gln Ala Arg Ser Lys Asn Ile Glu Ile Ile Tyr Val Gln His Ile 
        35                  40                  45              

Glu Asn Ser Glu Ala Gln Thr Ser Glu Asp Trp Gln Leu Ser Ala Leu 
    50                  55                  60                  

Leu Asn Arg Lys Pro Ala Glu Lys Val Phe Gln Lys Lys Tyr Asn Ser 
65                  70                  75                  80  

Ile Phe Lys Glu Thr Gly Leu Lys Glu Tyr Leu Asp Lys Gln Gly Ile 
                85                  90                  95      

Glu Lys Leu Val Leu Cys Gly Met Gln Thr Glu Tyr Cys Val Asp Thr 
            100                 105                 110         

Ser Val Lys Val Ala Phe Glu Tyr Gly Tyr Gln Leu Ile Val Pro Glu 
        115                 120                 125             

Gly Ala Val Thr Thr Phe Asp Gly Asp Asp Ile Pro Ala Glu Thr Ile 
    130                 135                 140                 

Asn Glu Phe Tyr Glu Asp Ile Trp Glu Glu Arg Phe Ala Asp Val Leu 
145                 150                 155                 160 

Asp Tyr Lys His Ile Phe 
                165     

<210>   3601
<211>   591
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3601
atgtcctatc aagactatat caactgctcc cgtgaggcct tgttggaaaa aatggcagag   60
cttctacctg agaaacgtct aacccattgt ctaggtgtgg agcgtgccgc tatggaatta   120
gctcagcgct ttggtgtaga tgttgagaaa gcaagtctag caggtcttct tcatgactat   180
gctaaaaagt tgtcagatca ggaatttcta gtcttgattg accgttacca gctagaccct   240
gacctcaaaa actggggcaa taatgtctgg catggtatgg tcggaattta caaaattcag   300
gaagatttgg atttgcatga ttctgaaatt ctgcgagcca ttgaaattca tacagtcgga   360
gctggtcaaa tgacagacct agataaggtc atctacgtcg cagactatat cgagcacaat   420
cgagcctttc ctggagtaga tgtggcgcgt gagattgcaa gtctatcgct caataaggcg   480
gtggcctacg aaacagctcg taccgtggag tatctagctc atcagggatt ccccatctat   540
ccccaaaccc ttgaaaccta taacgccttt gtgcactatt tgaaagagga c            591

<210>   3602
<211>   197
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903633 (e-110)

<400>   3602
Met Ser Tyr Gln Asp Tyr Ile Asn Cys Ser Arg Glu Ala Leu Leu Glu 
1               5                   10                  15      

Lys Met Ala Glu Leu Leu Pro Glu Lys Arg Leu Thr His Cys Leu Gly 
            20                  25                  30          

Val Glu Arg Ala Ala Met Glu Leu Ala Gln Arg Phe Gly Val Asp Val 
        35                  40                  45              

Glu Lys Ala Ser Leu Ala Gly Leu Leu His Asp Tyr Ala Lys Lys Leu 
    50                  55                  60                  

Ser Asp Gln Glu Phe Leu Val Leu Ile Asp Arg Tyr Gln Leu Asp Pro 
65                  70                  75                  80  

Asp Leu Lys Asn Trp Gly Asn Asn Val Trp His Gly Met Val Gly Ile 
                85                  90                  95      

Tyr Lys Ile Gln Glu Asp Leu Asp Leu His Asp Ser Glu Ile Leu Arg 
            100                 105                 110         

Ala Ile Glu Ile His Thr Val Gly Ala Gly Gln Met Thr Asp Leu Asp 
        115                 120                 125             

Lys Val Ile Tyr Val Ala Asp Tyr Ile Glu His Asn Arg Ala Phe Pro 
    130                 135                 140                 

Gly Val Asp Val Ala Arg Glu Ile Ala Ser Leu Ser Leu Asn Lys Ala 
145                 150                 155                 160 

Val Ala Tyr Glu Thr Ala Arg Thr Val Glu Tyr Leu Ala His Gln Gly 
                165                 170                 175     

Phe Pro Ile Tyr Pro Gln Thr Leu Glu Thr Tyr Asn Ala Phe Val His 
            180                 185                 190         

Tyr Leu Lys Glu Asp 
        195         

<210>   3603
<211>   627
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3603
atgacaatcg aactattgac tccctttacc aaggtagagt tggagccaga aatcaaggag   60
aaaaaacgca aacaagttgg gattttaggg gggaatttta accctgttca caatgcccat   120
ctcattgttg cggatcaagt acggcaacag ttgggactgg atcaagttct tctcatgcct   180
gaataccaac ctcctcacgt tgataaaaag gaaaccatcc ctgaacacca tcgtctcaag   240
atgcttgagt tggcaattga gggaattgac ggcctagtca ttgaaaccat tgagttggag   300
cgcaagggta tttcctacac ctacgacacc atgaagattt tgacagagaa gaatccagat   360
acggattatt actttatcat cggtgccgac atggttgact atctgcctaa gtggtaccga   420
attgatgaac tggttgacat ggttcagttt gtgggggttc agcgtccacg ctacaaggta   480
gggacttcct atccagttat ctgggtggac gtaccgctca tggatatctc gtccagcatg   540
gtgcgggact tccttgccca aggtcggaaa cccaactttc tcctacctca gccagtgcta   600
gactacatcg agaaggaagg gctctac                                       627

<210>   3604
<211>   209
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903634 (e-121)

<400>   3604
Met Thr Ile Glu Leu Leu Thr Pro Phe Thr Lys Val Glu Leu Glu Pro 
1               5                   10                  15      

Glu Ile Lys Glu Lys Lys Arg Lys Gln Val Gly Ile Leu Gly Gly Asn 
            20                  25                  30          


Phe Asn Pro Val His Asn Ala His Leu Ile Val Ala Asp Gln Val Arg 
        35                  40                  45              

Gln Gln Leu Gly Leu Asp Gln Val Leu Leu Met Pro Glu Tyr Gln Pro 
    50                  55                  60                  

Pro His Val Asp Lys Lys Glu Thr Ile Pro Glu His His Arg Leu Lys 
65                  70                  75                  80  

Met Leu Glu Leu Ala Ile Glu Gly Ile Asp Gly Leu Val Ile Glu Thr 
                85                  90                  95      

Ile Glu Leu Glu Arg Lys Gly Ile Ser Tyr Thr Tyr Asp Thr Met Lys 
            100                 105                 110         

Ile Leu Thr Glu Lys Asn Pro Asp Thr Asp Tyr Tyr Phe Ile Ile Gly 
        115                 120                 125             

Ala Asp Met Val Asp Tyr Leu Pro Lys Trp Tyr Arg Ile Asp Glu Leu 
    130                 135                 140                 

Val Asp Met Val Gln Phe Val Gly Val Gln Arg Pro Arg Tyr Lys Val 
145                 150                 155                 160 

Gly Thr Ser Tyr Pro Val Ile Trp Val Asp Val Pro Leu Met Asp Ile 
                165                 170                 175     

Ser Ser Ser Met Val Arg Asp Phe Leu Ala Gln Gly Arg Lys Pro Asn 
            180                 185                 190         

Phe Leu Leu Pro Gln Pro Val Leu Asp Tyr Ile Glu Lys Glu Gly Leu 
        195                 200                 205             

Tyr 
    

<210>   3605
<211>   309
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3605
atgtcattaa catcaaaaca acgtgccttc ctcaacagcc aggcacacac cctcaaacct   60
atcatccaaa tcgggaaaaa tggactcaac gaccaaatca aaaccagcgt ccgtcaagct   120
cttgatgcgc gtgaattaat caaggttact ctcttacaaa acacagatga aaacatccac   180
gaagtagctg aaattttgga agaagaaatc ggtgtggata cagtccaaaa aataggacgc   240
atcttgattt tgtttaaaca atctagcaag aaagaaaatc gcaagatttc taagaaagtc   300
aaagaaatc                                                           309

<210>   3606
<211>   103
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903635 (3.E-52)

<400>   3606
Met Ser Leu Thr Ser Lys Gln Arg Ala Phe Leu Asn Ser Gln Ala His 
1               5                   10                  15      

Thr Leu Lys Pro Ile Ile Gln Ile Gly Lys Asn Gly Leu Asn Asp Gln 
            20                  25                  30          

Ile Lys Thr Ser Val Arg Gln Ala Leu Asp Ala Arg Glu Leu Ile Lys 
        35                  40                  45              


Val Thr Leu Leu Gln Asn Thr Asp Glu Asn Ile His Glu Val Ala Glu 
    50                  55                  60                  

Ile Leu Glu Glu Glu Ile Gly Val Asp Thr Val Gln Lys Ile Gly Arg 
65                  70                  75                  80  

Ile Leu Ile Leu Phe Lys Gln Ser Ser Lys Lys Glu Asn Arg Lys Ile 
                85                  90                  95      

Ser Lys Lys Val Lys Glu Ile 
            100             

<210>   3607
<211>   1104
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3607
atggaagaaa ttctctgtat tggttgtgga gcaaccattc agacgacaga taaagctggt   60
cttggtttta ccccccagtc ggcacttgaa aaaggtttgg agactggcga agtctattgc   120
caacgctgtt tccgtctccg ccactacaat gaaatcacag atgtccagtt gacgaacgat   180
gatttcctca agctcttgca cgaggtggga gacagtgatg ctttagtggt caatgttatt   240
gatatctttg attttaatgg atctgtcatc ccaggtttac cacgtttcgt ctcgggcaat   300
gatgtcctct tggtaggaaa taaaaaagat atccttccta agtcagttaa gtctggtaag   360
attagccagt ggctcatgaa acgtgcccat gaagaaggtc ttcgtccagt cgatgtggtc   420
ctaacttcag cacaaaataa acatgccatt aaggaagtca ttgacaagat tgaacactac   480
cgtaagggcc gcgatgtcta tgtggtcggt gtgaccaacg ttggaaaatc aactctaatc   540
aatgctatta tccaagaaat cacgggtgat cagaatgtca tcactacttc acgcttccca   600
gggacaacct tggacaaaat agagattccg cttgacgacg gatcttatat ttacgatacg   660
ccgggaatta tccaccgcca ccagatggct cactacttga cggccaaaaa cctcaagtat   720
gtcagtccta aaaaggaaat caagcctaag acctatcagc ttaatcctga gcaaacccta   780
tttttaggtg gtttgggacg ctttgacttt atagcaggag aaaagcaagg atttactgct   840
ttctttgata atgaactcaa actccatcgt agcaagcttg aaggagctag tgctttctac   900
gataagcacc tgggaactct tctgacacca ccaaatagca aggaaaaaga agatttccca   960
aggctagtcc agcatgtctt taccattaaa gataagacag acctagttat ctcaggccta   1020
ggatggattc gtgtaacagg catagcaaaa gtcgccgtct gggcaccaga aggcgtcgcc   1080
gtcgtcacac gaaaagcaat tatt                                          1104

<210>   3608
<211>   368
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903636 (0.E+01)

<400>   3608
Met Glu Glu Ile Leu Cys Ile Gly Cys Gly Ala Thr Ile Gln Thr Thr 
1               5                   10                  15      

Asp Lys Ala Gly Leu Gly Phe Thr Pro Gln Ser Ala Leu Glu Lys Gly 
            20                  25                  30          

Leu Glu Thr Gly Glu Val Tyr Cys Gln Arg Cys Phe Arg Leu Arg His 
        35                  40                  45              

Tyr Asn Glu Ile Thr Asp Val Gln Leu Thr Asn Asp Asp Phe Leu Lys 
    50                  55                  60                  

Leu Leu His Glu Val Gly Asp Ser Asp Ala Leu Val Val Asn Val Ile 
65                  70                  75                  80  

Asp Ile Phe Asp Phe Asn Gly Ser Val Ile Pro Gly Leu Pro Arg Phe 
                85                  90                  95      

Val Ser Gly Asn Asp Val Leu Leu Val Gly Asn Lys Lys Asp Ile Leu 
            100                 105                 110         

Pro Lys Ser Val Lys Ser Gly Lys Ile Ser Gln Trp Leu Met Lys Arg 
        115                 120                 125             

Ala His Glu Glu Gly Leu Arg Pro Val Asp Val Val Leu Thr Ser Ala 
    130                 135                 140                 

Gln Asn Lys His Ala Ile Lys Glu Val Ile Asp Lys Ile Glu His Tyr 
145                 150                 155                 160 

Arg Lys Gly Arg Asp Val Tyr Val Val Gly Val Thr Asn Val Gly Lys 
                165                 170                 175     

Ser Thr Leu Ile Asn Ala Ile Ile Gln Glu Ile Thr Gly Asp Gln Asn 
            180                 185                 190         

Val Ile Thr Thr Ser Arg Phe Pro Gly Thr Thr Leu Asp Lys Ile Glu 
        195                 200                 205             

Ile Pro Leu Asp Asp Gly Ser Tyr Ile Tyr Asp Thr Pro Gly Ile Ile 
    210                 215                 220                 

His Arg His Gln Met Ala His Tyr Leu Thr Ala Lys Asn Leu Lys Tyr 
225                 230                 235                 240 

Val Ser Pro Lys Lys Glu Ile Lys Pro Lys Thr Tyr Gln Leu Asn Pro 
                245                 250                 255     

Glu Gln Thr Leu Phe Leu Gly Gly Leu Gly Arg Phe Asp Phe Ile Ala 
            260                 265                 270         


Gly Glu Lys Gln Gly Phe Thr Ala Phe Phe Asp Asn Glu Leu Lys Leu 
        275                 280                 285             

His Arg Ser Lys Leu Glu Gly Ala Ser Ala Phe Tyr Asp Lys His Leu 
    290                 295                 300                 

Gly Thr Leu Leu Thr Pro Pro Asn Ser Lys Glu Lys Glu Asp Phe Pro 
305                 310                 315                 320 

Arg Leu Val Gln His Val Phe Thr Ile Lys Asp Lys Thr Asp Leu Val 
                325                 330                 335     

Ile Ser Gly Leu Gly Trp Ile Arg Val Thr Gly Ile Ala Lys Val Ala 
            340                 345                 350         

Val Trp Ala Pro Glu Gly Val Ala Val Val Thr Arg Lys Ala Ile Ile 
        355                 360                 365             


<210>   3609
<211>   525
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3609
atggcgattg aaaattatat accagatttt gctgtggaag cagtctatga tctgacagtc   60
ccaagcctgc aggcgcaggg aataaaggct gttttggtcg atttggataa taccctcatt   120
gcttggaaca accctgatgg aacgccagag atgaagcaat ggctacatga ccttcgggac   180
gcgggtattg gcattatcgt agtgtcaaat aacaccaaaa aacgcgttca acgagcagtt   240
gagaaatttg ggattgatta cgtttactgg gccttgaagc ccttcacatt tggtattgac   300
cgtgctatga aggaattcca ctatgacaaa aaggaagtgg tcatggttgg tgaccaactc   360
atgacagata tacgagcagc ccaccgtgca gggattcggt caattttagt caaacccttg   420
gtccaacatg actcaatcaa aacgcagatt aaccgaactc gtgagcgtcg tgttatgaga   480
aaaatcactg aaaagtacgg accgattaca tataaaaaag gaatt                   525

<210>   3610
<211>   175
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903637 (7.E-99)

<400>   3610
Met Ala Ile Glu Asn Tyr Ile Pro Asp Phe Ala Val Glu Ala Val Tyr 
1               5                   10                  15      

Asp Leu Thr Val Pro Ser Leu Gln Ala Gln Gly Ile Lys Ala Val Leu 
            20                  25                  30          

Val Asp Leu Asp Asn Thr Leu Ile Ala Trp Asn Asn Pro Asp Gly Thr 
        35                  40                  45              

Pro Glu Met Lys Gln Trp Leu His Asp Leu Arg Asp Ala Gly Ile Gly 
    50                  55                  60                  

Ile Ile Val Val Ser Asn Asn Thr Lys Lys Arg Val Gln Arg Ala Val 
65                  70                  75                  80  

Glu Lys Phe Gly Ile Asp Tyr Val Tyr Trp Ala Leu Lys Pro Phe Thr 
                85                  90                  95      

Phe Gly Ile Asp Arg Ala Met Lys Glu Phe His Tyr Asp Lys Lys Glu 
            100                 105                 110         

Val Val Met Val Gly Asp Gln Leu Met Thr Asp Ile Arg Ala Ala His 
        115                 120                 125             

Arg Ala Gly Ile Arg Ser Ile Leu Val Lys Pro Leu Val Gln His Asp 
    130                 135                 140                 

Ser Ile Lys Thr Gln Ile Asn Arg Thr Arg Glu Arg Arg Val Met Arg 
145                 150                 155                 160 

Lys Ile Thr Glu Lys Tyr Gly Pro Ile Thr Tyr Lys Lys Gly Ile 
                165                 170                 175 

<210>   3611
<211>   906
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3611
atggttttag aaaagcagtt gggcaatggt tgtacctgga tagacctaga cctaggaaag   60
ttgaataaac tagaagacct ttctgaaatt tacggtttgg acaaggaaac cattgaatac   120
gcactggata gaaacgagcg cgcccacatg gactaccacc gtgaaagtga gacggttacc   180
tttatctata atgtcttaga cgtaaaaaag gacaaggcct actatgagac ttttcccatg   240
acctttattg tcgagcatcg tcgcctgatt accattagta ataccaagaa cgcctatgtc   300
attgaacaga tgactcgtta tctggagaac catgacacgc tttcgattta taagtttctc   360
tttgccagtc tggaaatcat cagcaatgcc tactatcctg tcattgagca gatggacaag   420
agtagggatg aggtcaatga cctcttgcgc cagcgaacta ccaagaaaaa cctctttgtc   480
ctgtctgatt tggagactgg tatggtttat ctgacggcag ctgccaaaca aaatcggatt   540
ttgttagagc atattcaagg tcatgccttg tatcgtagtt ttgatgagat tgagagagaa   600
cagtttgatg atgccatgat tgaggctcat cagctggtat ccatgacaga cctaatctct   660
cagattttac agcagctttc agcctcttac aacaatattc taaacaataa tctgaatgac   720
aatttgacaa ccttgactat catttcagtc ttgctagctg ttttggcagt cgtgacaggc   780
tttttcggaa tgaatgttcc cttaccttta acagatgagc cccatgcttg gctctatatc   840
agtttggcta gtgcaggttt gtggattgtt ttatccttgt tactaaggaa aattgcgaaa   900
aaaagt                                                              906

<210>   3612
<211>   302
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   magnesium transporter, CorA family, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903638 (e-166)

<400>   3612
Met Val Leu Glu Lys Gln Leu Gly Asn Gly Cys Thr Trp Ile Asp Leu 
1               5                   10                  15      

Asp Leu Gly Lys Leu Asn Lys Leu Glu Asp Leu Ser Glu Ile Tyr Gly 
            20                  25                  30          

Leu Asp Lys Glu Thr Ile Glu Tyr Ala Leu Asp Arg Asn Glu Arg Ala 
        35                  40                  45              

His Met Asp Tyr His Arg Glu Ser Glu Thr Val Thr Phe Ile Tyr Asn 
    50                  55                  60                  

Val Leu Asp Val Lys Lys Asp Lys Ala Tyr Tyr Glu Thr Phe Pro Met 
65                  70                  75                  80  

Thr Phe Ile Val Glu His Arg Arg Leu Ile Thr Ile Ser Asn Thr Lys 
                85                  90                  95      

Asn Ala Tyr Val Ile Glu Gln Met Thr Arg Tyr Leu Glu Asn His Asp 
            100                 105                 110         

Thr Leu Ser Ile Tyr Lys Phe Leu Phe Ala Ser Leu Glu Ile Ile Ser 
        115                 120                 125             

Asn Ala Tyr Tyr Pro Val Ile Glu Gln Met Asp Lys Ser Arg Asp Glu 
    130                 135                 140                 

Val Asn Asp Leu Leu Arg Gln Arg Thr Thr Lys Lys Asn Leu Phe Val 
145                 150                 155                 160 

Leu Ser Asp Leu Glu Thr Gly Met Val Tyr Leu Thr Ala Ala Ala Lys 
                165                 170                 175     

Gln Asn Arg Ile Leu Leu Glu His Ile Gln Gly His Ala Leu Tyr Arg 
            180                 185                 190         

Ser Phe Asp Glu Ile Glu Arg Glu Gln Phe Asp Asp Ala Met Ile Glu 
        195                 200                 205             

Ala His Gln Leu Val Ser Met Thr Asp Leu Ile Ser Gln Ile Leu Gln 
    210                 215                 220                 

Gln Leu Ser Ala Ser Tyr Asn Asn Ile Leu Asn Asn Asn Leu Asn Asp 
225                 230                 235                 240 

Asn Leu Thr Thr Leu Thr Ile Ile Ser Val Leu Leu Ala Val Leu Ala 
                245                 250                 255     

Val Val Thr Gly Phe Phe Gly Met Asn Val Pro Leu Pro Leu Thr Asp 
            260                 265                 270         

Glu Pro His Ala Trp Leu Tyr Ile Ser Leu Ala Ser Ala Gly Leu Trp 
        275                 280                 285             

Ile Val Leu Ser Leu Leu Leu Arg Lys Ile Ala Lys Lys Ser 
    290                 295                 300         

<210>   3613
<211>   603
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3613
atgagactga tgaaaatatg gtataatgaa ataaaggagt tttatatgca aaaatttatt   60
caggcttata ttgaaaagct agatgtgaca accattatcg agaatattct aaccaaggtc   120
atttctcttt tactgctttt aattgtattt tatattgcta aaaaaatgct tcataccatg   180
gtgcagagaa ttgtcaaacc ttctctaaaa atgtctcgtc atgatgttgg acgccaaaaa   240
accatctcac gtttactaga aaatgtgttt aattatacgc tatatttctt tttactctac   300
tgcattttgt cgattttagg tttgccagtt tctagtttgc tggctggagc tggtattgct   360
ggggtagcga ttggtatggg agcccaaggc tttctgtctg atgtcatcaa tggctttttc   420
atcctctttg aacgtcaact ggatgtggga gatgaggtcg ttctgacaaa tggaccgatt   480
actgtatcgg gtaaggttgt cagtgtggga attcgtacga cacagcttcg tagcgaggag   540
caagcccttc actttgtccc taaccgaaat atcacagttg ttagcaattt ctcacgcaca   600
gac                                                                 603

<210>   3614
<211>   201
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903639 (e-109)

<400>   3614
Met Arg Leu Met Lys Ile Trp Tyr Asn Glu Ile Lys Glu Phe Tyr Met 
1               5                   10                  15      

Gln Lys Phe Ile Gln Ala Tyr Ile Glu Lys Leu Asp Val Thr Thr Ile 
            20                  25                  30          

Ile Glu Asn Ile Leu Thr Lys Val Ile Ser Leu Leu Leu Leu Leu Ile 
        35                  40                  45              

Val Phe Tyr Ile Ala Lys Lys Met Leu His Thr Met Val Gln Arg Ile 
    50                  55                  60                  

Val Lys Pro Ser Leu Lys Met Ser Arg His Asp Val Gly Arg Gln Lys 
65                  70                  75                  80  

Thr Ile Ser Arg Leu Leu Glu Asn Val Phe Asn Tyr Thr Leu Tyr Phe 
                85                  90                  95      

Phe Leu Leu Tyr Cys Ile Leu Ser Ile Leu Gly Leu Pro Val Ser Ser 
            100                 105                 110         

Leu Leu Ala Gly Ala Gly Ile Ala Gly Val Ala Ile Gly Met Gly Ala 
        115                 120                 125             

Gln Gly Phe Leu Ser Asp Val Ile Asn Gly Phe Phe Ile Leu Phe Glu 
    130                 135                 140                 

Arg Gln Leu Asp Val Gly Asp Glu Val Val Leu Thr Asn Gly Pro Ile 
145                 150                 155                 160 

Thr Val Ser Gly Lys Val Val Ser Val Gly Ile Arg Thr Thr Gln Leu 
                165                 170                 175     

Arg Ser Glu Glu Gln Ala Leu His Phe Val Pro Asn Arg Asn Ile Thr 
            180                 185                 190         

Val Val Ser Asn Phe Ser Arg Thr Asp 
        195                 200     

<210>   3615
<211>   186
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3615
ttgtggggaa tcctaggact gacccttcct aatctctcag ggattgggct actcgaggat   60
ttattcgttg gaggtctaaa agctgttgct cctatcctag tctttgctct cgttgccaat   120
gccctttccc aacatcaaaa gggacaagat agcaatatga aaactgttgt tttcttgtat   180
atccta                                                              186

<210>   3616
<211>   62
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sodium/dicarboxylate symporter family protein-related

<400>   3616
Met Trp Gly Ile Leu Gly Leu Thr Leu Pro Asn Leu Ser Gly Ile Gly 
1               5                   10                  15      

Leu Leu Glu Asp Leu Phe Val Gly Gly Leu Lys Ala Val Ala Pro Ile 
            20                  25                  30          

Leu Val Phe Ala Leu Val Ala Asn Ala Leu Ser Gln His Gln Lys Gly 
        35                  40                  45              

Gln Asp Ser Asn Met Lys Thr Val Val Phe Leu Tyr Ile Leu 
    50                  55                  60          

<210>   3617
<211>   957
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3617
atgataggga ctttcgccgc tgctcttgta gctgtactag caaatttcat cgtccctatt   60
gaaattaccc caaatagtgc caatactgaa attgcaccac cagatgggat tgggcaggtt   120
ctcagcaacc tcttgctcaa actggttgac aacccagtca acgccctgct tactgctaac   180
tatattagaa tcttatcttg ggcagtcatt tttggaatcg ctatgagaga agccagtaaa   240
aatagtcaag aattgctaaa aactatcgct gacgtgactt ctaaaattgt cgaatggatc   300
atcaatctgg ctccatttgg aatccttggt cttgttttta aaaccatttc tgacaaggga   360
gtcggaagcc ttgccaacta cggtatttta ttggttctat tagtaacgac tatgcttttt   420
gttgcccctg tggtcaaccc tttgattgcc ttcttcttta tgagacgcaa tccttaccct   480
ctagtttgga actgcctccg tgtcagcggt gtgacagcct ttttcactcg tagttctgcg   540
actaacattc ctgtcaacat gaaactctgc catgaccttg gactcaaccc agatacctat   600
tctgtttcta tcccactcgg ttctactatc aatatggctg gagtagcgat taccattaac   660
cttttgaccc ttgctgcagt taacactctt ggaattcctg ttgactttgc cacagccttt   720
gtcctcagtg tggtagcagc tatctcatcc tgtgatgctt caggtattgc cggaggttcc   780
ctccttctta tcccagttgc ttgtagcctt ttcggtattt ctaacgatat tgccatacaa   840
attgttgggg ttggttttgt gattggtgtc atccaagact catgtgaaac agcccttaac   900
tcttctacag atgtcctctt taccgccgtt gccgaatacg cagcaacccg taaaaaa      957

<210>   3618
<211>   319
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sodium/dicarboxylate symporter family protein

<400>   3618
Met Ile Gly Thr Phe Ala Ala Ala Leu Val Ala Val Leu Ala Asn Phe 
1               5                   10                  15      

Ile Val Pro Ile Glu Ile Thr Pro Asn Ser Ala Asn Thr Glu Ile Ala 
            20                  25                  30          

Pro Pro Asp Gly Ile Gly Gln Val Leu Ser Asn Leu Leu Leu Lys Leu 
        35                  40                  45              

Val Asp Asn Pro Val Asn Ala Leu Leu Thr Ala Asn Tyr Ile Arg Ile 
    50                  55                  60                  

Leu Ser Trp Ala Val Ile Phe Gly Ile Ala Met Arg Glu Ala Ser Lys 
65                  70                  75                  80  

Asn Ser Gln Glu Leu Leu Lys Thr Ile Ala Asp Val Thr Ser Lys Ile 
                85                  90                  95      

Val Glu Trp Ile Ile Asn Leu Ala Pro Phe Gly Ile Leu Gly Leu Val 
            100                 105                 110         

Phe Lys Thr Ile Ser Asp Lys Gly Val Gly Ser Leu Ala Asn Tyr Gly 
        115                 120                 125             

Ile Leu Leu Val Leu Leu Val Thr Thr Met Leu Phe Val Ala Pro Val 
    130                 135                 140                 

Val Asn Pro Leu Ile Ala Phe Phe Phe Met Arg Arg Asn Pro Tyr Pro 
145                 150                 155                 160 

Leu Val Trp Asn Cys Leu Arg Val Ser Gly Val Thr Ala Phe Phe Thr 
                165                 170                 175     

Arg Ser Ser Ala Thr Asn Ile Pro Val Asn Met Lys Leu Cys His Asp 
            180                 185                 190         

Leu Gly Leu Asn Pro Asp Thr Tyr Ser Val Ser Ile Pro Leu Gly Ser 
        195                 200                 205             

Thr Ile Asn Met Ala Gly Val Ala Ile Thr Ile Asn Leu Leu Thr Leu 
    210                 215                 220                 

Ala Ala Val Asn Thr Leu Gly Ile Pro Val Asp Phe Ala Thr Ala Phe 
225                 230                 235                 240 

Val Leu Ser Val Val Ala Ala Ile Ser Ser Cys Asp Ala Ser Gly Ile 
                245                 250                 255     

Ala Gly Gly Ser Leu Leu Leu Ile Pro Val Ala Cys Ser Leu Phe Gly 
            260                 265                 270         

Ile Ser Asn Asp Ile Ala Ile Gln Ile Val Gly Val Gly Phe Val Ile 
        275                 280                 285             

Gly Val Ile Gln Asp Ser Cys Glu Thr Ala Leu Asn Ser Ser Thr Asp 
    290                 295                 300                 

Val Leu Phe Thr Ala Val Ala Glu Tyr Ala Ala Thr Arg Lys Lys 
305                 310                 315                 

<210>   3619
<211>   951
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3619
atgtctatta gccaacgtac gaccaagctc atcttagcta cctgtcttgc ctgcctgctt   60
gcttattttc tcaatctttc gtcagcagtt tcggctggaa ttatcgctct cttgagccta   120
tctgatacgc gtagaagtac tttaaaactg gctcgcaatc gtcttttttc tatgcttcta   180
gctctggcta tcggtgttct agcttttcac ttgagcggat ttcatatctg gagtctcggc   240
ctctatctgg ccttctacgt tcctttagcc tacaagatgg gctgggaaat tggcatcaca   300
ccaagcactg ttttggttag ccatctcttg gttcaagagt caacctctcc agaccttcta   360
gtcaatgaat tccttctctt tgctattggt acaggatttg ccttgcttgt taatctctat   420
atgccttcac gagaagagga aatccagcac taccacacgc tggtggaaga aaagttaaaa   480
gatatcctcc agcgcttcaa atactattta tccagaggag acggacgcaa ccgagcacag   540
ctggtagcag aattagacac gcttttgaaa gaagccctca gactggtcta tttggatcac   600
tctgaccacc tctttcacca gacagactac catatccact actttgagat gagacagcga   660
caaagtcgta tcctgagaaa catggcccaa cagattaaca cttgtcacct tgccgccagt   720
gaaagcctga tcttagcgca actcttttca aaaattgcag gtcaactgag ccagaccaat   780
cctgcttctg atttgctaga tgaaattgaa cgttatctgg aagtcttccg gaaccgcagt   840
ctgcccaaga caagagaaga atttgaaacc cgcgccaccc ttcttcaact cctacgtgaa   900
gccaaaacct tcatccaagt aaaagttgat ttttaccaaa aatatagaca g            951

<210>   3620
<211>   317
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15903641 (e-178)

<400>   3620
Met Ser Ile Ser Gln Arg Thr Thr Lys Leu Ile Leu Ala Thr Cys Leu 
1               5                   10                  15      

Ala Cys Leu Leu Ala Tyr Phe Leu Asn Leu Ser Ser Ala Val Ser Ala 
            20                  25                  30          

Gly Ile Ile Ala Leu Leu Ser Leu Ser Asp Thr Arg Arg Ser Thr Leu 
        35                  40                  45              

Lys Leu Ala Arg Asn Arg Leu Phe Ser Met Leu Leu Ala Leu Ala Ile 
    50                  55                  60                  

Gly Val Leu Ala Phe His Leu Ser Gly Phe His Ile Trp Ser Leu Gly 
65                  70                  75                  80  

Leu Tyr Leu Ala Phe Tyr Val Pro Leu Ala Tyr Lys Met Gly Trp Glu 
                85                  90                  95      

Ile Gly Ile Thr Pro Ser Thr Val Leu Val Ser His Leu Leu Val Gln 
            100                 105                 110         

Glu Ser Thr Ser Pro Asp Leu Leu Val Asn Glu Phe Leu Leu Phe Ala 
        115                 120                 125             

Ile Gly Thr Gly Phe Ala Leu Leu Val Asn Leu Tyr Met Pro Ser Arg 
    130                 135                 140                 

Glu Glu Glu Ile Gln His Tyr His Thr Leu Val Glu Glu Lys Leu Lys 
145                 150                 155                 160 

Asp Ile Leu Gln Arg Phe Lys Tyr Tyr Leu Ser Arg Gly Asp Gly Arg 
                165                 170                 175     

Asn Arg Ala Gln Leu Val Ala Glu Leu Asp Thr Leu Leu Lys Glu Ala 
            180                 185                 190         

Leu Arg Leu Val Tyr Leu Asp His Ser Asp His Leu Phe His Gln Thr 
        195                 200                 205             

Asp Tyr His Ile His Tyr Phe Glu Met Arg Gln Arg Gln Ser Arg Ile 
    210                 215                 220                 

Leu Arg Asn Met Ala Gln Gln Ile Asn Thr Cys His Leu Ala Ala Ser 
225                 230                 235                 240 

Glu Ser Leu Ile Leu Ala Gln Leu Phe Ser Lys Ile Ala Gly Gln Leu 
                245                 250                 255     

Ser Gln Thr Asn Pro Ala Ser Asp Leu Leu Asp Glu Ile Glu Arg Tyr 
            260                 265                 270         

Leu Glu Val Phe Arg Asn Arg Ser Leu Pro Lys Thr Arg Glu Glu Phe 
        275                 280                 285             

Glu Thr Arg Ala Thr Leu Leu Gln Leu Leu Arg Glu Ala Lys Thr Phe 
    290                 295                 300                 

Ile Gln Val Lys Val Asp Phe Tyr Gln Lys Tyr Arg Gln 
305                 310                 315         

<210>   3621
<211>   372
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3621
ttgtggattg gtctgaagtt ttctttttta tactcaatga aaatcaaaga gcaaactagg   60
aagctagccg caggctgctc aaaacaccgt tttgaggttg tagatataac tgacgaagtc   120
agctcaaaac accgttttga ggttgtagat ataactgacg aagtcagctc aaaacaccgt   180
tttgaggttg tggatagaac tgacgaagtc agctcaaaac accgttttga ggttgtggat   240
agaactgacg aagtcagctc aaaacaccgt tttgaggttg tggatagaac tgacgaagtc   300
agctcaaaac accgttttga ggttgtggat agaactgacg aagtcagtaa catatataca   360
gcaaggcgac gc                                                       372

<210>   3622
<211>   124
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3622
Met Trp Ile Gly Leu Lys Phe Ser Phe Leu Tyr Ser Met Lys Ile Lys 
1               5                   10                  15      

Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys His Arg Phe Glu 
            20                  25                  30          

Val Val Asp Ile Thr Asp Glu Val Ser Ser Lys His Arg Phe Glu Val 
        35                  40                  45              

Val Asp Ile Thr Asp Glu Val Ser Ser Lys His Arg Phe Glu Val Val 
    50                  55                  60                  

Asp Arg Thr Asp Glu Val Ser Ser Lys His Arg Phe Glu Val Val Asp 
65                  70                  75                  80  

Arg Thr Asp Glu Val Ser Ser Lys His Arg Phe Glu Val Val Asp Arg 
                85                  90                  95      

Thr Asp Glu Val Ser Ser Lys His Arg Phe Glu Val Val Asp Arg Thr 
            100                 105                 110         

Asp Glu Val Ser Asn Ile Tyr Thr Ala Arg Arg Arg 
        115                 120                 

<210>   3623
<211>   222
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3623
atgattgaaa tactaattgt tttagctatt atcctatctc ttgctttgat tgtattggta   60
actatacaac cccgtcaaaa tcaactattt tccatggatg ccactagtaa tattggtaaa   120
ccaagctact ggcagagcaa caccttggtc aaggtgctca ctttattggt gagtttggct   180
ttatttattc tactattaac ctttatggtg attacttata aa                      222

<210>   3624
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   3624
Met Ile Glu Ile Leu Ile Val Leu Ala Ile Ile Leu Ser Leu Ala Leu 
1               5                   10                  15      

Ile Val Leu Val Thr Ile Gln Pro Arg Gln Asn Gln Leu Phe Ser Met 
            20                  25                  30          

Asp Ala Thr Ser Asn Ile Gly Lys Pro Ser Tyr Trp Gln Ser Asn Thr 
        35                  40                  45              

Leu Val Lys Val Leu Thr Leu Leu Val Ser Leu Ala Leu Phe Ile Leu 
    50                  55                  60                  

Leu Leu Thr Phe Met Val Ile Thr Tyr Lys 
65                  70                  

<210>   3625
<211>   177
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3625
atgtcagagg aagatttatt ttacaaagac gttgaaggcc gcatggaaga gttgaaacaa   60
aaacccatca agaaggaaaa agaaacccga ggggaaaaga ttagtaagac tttttcactt   120
ttactgggtt tgatgattct gattggtttg ctctttactt tgctgggaat tttgagg      177

<210>   3626
<211>   59
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane

<400>   3626
Met Ser Glu Glu Asp Leu Phe Tyr Lys Asp Val Glu Gly Arg Met Glu 
1               5                   10                  15      

Glu Leu Lys Gln Lys Pro Ile Lys Lys Glu Lys Glu Thr Arg Gly Glu 
            20                  25                  30          

Lys Ile Ser Lys Thr Phe Ser Leu Leu Leu Gly Leu Met Ile Leu Ile 
        35                  40                  45              

Gly Leu Leu Phe Thr Leu Leu Gly Ile Leu Arg 
    50                  55                  

<210>   3627
<211>   1335
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3627
atgattgaac tttatgatag ttacagtcaa gaaagtcgag atttacatga aagtctaggc   60
gctactggtc tttctcaact tggagtggtc atcgatgcag atggttttct gcctgatggt   120
ctgctttctc cttttaccta ttatctaggt tacgaggatg gaaaacctct ctattttaat   180
caagttcccg tttcagattt ttgggaaatt ttaggagata atcagtctgc ttgtattgaa   240
gatgtgacgc aggagagggc tgtcattcat tatgctgatg gaatgcaggc tcgcttggtt   300
aaacaggtag actggaaaga cctagaaggt cgagtacgtc aggttgacca ctacaatcgc   360
ttcggagctt gttttgctac aacgacttat agcgcagata gcgagccgat tatgacagtt   420
taccaagatg tcaatggtca acaagtttta ctggaaaacc atgtgacggg tgatatctta   480
ttgactttgc caggtcagtc catgcgttac tttgcaaata aagttgaatt tatcaccttc   540
tttttgcaag atttggaaat agataccagt cagcttatct ttaatactct agcgactcct   600
ttcttggttt ccttccatca tccagataaa tctggctcgg atgtcttggt atggcaggaa   660
cctctctatg atgccattcc aggtaatatg cagttgattt tggaaagtga taatgtgcgt   720
actaagaaga tcatcattcc aaataaggcg acttatgagc gcgctttaga gttaactgac   780
gagaaatacc atgatcagtt tgtgcacttg ggttatcatt accagttcaa acgtgataat   840
ttcctaagac gagatgcctt aatcttgacc aattcagatc agattgagca agtagaagca   900
atcgcaggag ccttgcctga tgtcactttc cgtattgcag cggtgacaga gatgtcttct   960
aagctcttag acatgctttg ctatcctaat gtggcccttt accagaacgc tagtccacag   1020
aagattcagg agctgtatca actgtcggat atttacttgg atataaacca cagtaatgag   1080
ttgctacagg cagtgcgtca ggcctttgag cacaatctct tgattcttgg ctttaatcag   1140
acggtgcaca atagacttta tatcgctcca gaccatctat ttgaaagtag tgaagttgct   1200
gctttggttg agaccattaa attggccctt tcagatgttg atcaaatgcg tcaggcactt   1260
ggcaaacaag gccaacatgc aaattatgtt gacttggtga gatatcagga aaccatgcaa   1320
actgttttag gaggc                                                    1335

<210>   3628
<211>   445
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3628
Met Ile Glu Leu Tyr Asp Ser Tyr Ser Gln Glu Ser Arg Asp Leu His 
1               5                   10                  15      

Glu Ser Leu Gly Ala Thr Gly Leu Ser Gln Leu Gly Val Val Ile Asp 
            20                  25                  30          

Ala Asp Gly Phe Leu Pro Asp Gly Leu Leu Ser Pro Phe Thr Tyr Tyr 
        35                  40                  45              

Leu Gly Tyr Glu Asp Gly Lys Pro Leu Tyr Phe Asn Gln Val Pro Val 
    50                  55                  60                  

Ser Asp Phe Trp Glu Ile Leu Gly Asp Asn Gln Ser Ala Cys Ile Glu 
65                  70                  75                  80  

Asp Val Thr Gln Glu Arg Ala Val Ile His Tyr Ala Asp Gly Met Gln 
                85                  90                  95      

Ala Arg Leu Val Lys Gln Val Asp Trp Lys Asp Leu Glu Gly Arg Val 
            100                 105                 110         

Arg Gln Val Asp His Tyr Asn Arg Phe Gly Ala Cys Phe Ala Thr Thr 
        115                 120                 125             

Thr Tyr Ser Ala Asp Ser Glu Pro Ile Met Thr Val Tyr Gln Asp Val 
    130                 135                 140                 

Asn Gly Gln Gln Val Leu Leu Glu Asn His Val Thr Gly Asp Ile Leu 
145                 150                 155                 160 

Leu Thr Leu Pro Gly Gln Ser Met Arg Tyr Phe Ala Asn Lys Val Glu 
                165                 170                 175     

Phe Ile Thr Phe Phe Leu Gln Asp Leu Glu Ile Asp Thr Ser Gln Leu 
            180                 185                 190         

Ile Phe Asn Thr Leu Ala Thr Pro Phe Leu Val Ser Phe His His Pro 
        195                 200                 205             

Asp Lys Ser Gly Ser Asp Val Leu Val Trp Gln Glu Pro Leu Tyr Asp 
    210                 215                 220                 

Ala Ile Pro Gly Asn Met Gln Leu Ile Leu Glu Ser Asp Asn Val Arg 
225                 230                 235                 240 

Thr Lys Lys Ile Ile Ile Pro Asn Lys Ala Thr Tyr Glu Arg Ala Leu 
                245                 250                 255     

Glu Leu Thr Asp Glu Lys Tyr His Asp Gln Phe Val His Leu Gly Tyr 
            260                 265                 270         

His Tyr Gln Phe Lys Arg Asp Asn Phe Leu Arg Arg Asp Ala Leu Ile 
        275                 280                 285             

Leu Thr Asn Ser Asp Gln Ile Glu Gln Val Glu Ala Ile Ala Gly Ala 
    290                 295                 300                 

Leu Pro Asp Val Thr Phe Arg Ile Ala Ala Val Thr Glu Met Ser Ser 
305                 310                 315                 320 

Lys Leu Leu Asp Met Leu Cys Tyr Pro Asn Val Ala Leu Tyr Gln Asn 
                325                 330                 335     

Ala Ser Pro Gln Lys Ile Gln Glu Leu Tyr Gln Leu Ser Asp Ile Tyr 
            340                 345                 350         

Leu Asp Ile Asn His Ser Asn Glu Leu Leu Gln Ala Val Arg Gln Ala 
        355                 360                 365             

Phe Glu His Asn Leu Leu Ile Leu Gly Phe Asn Gln Thr Val His Asn 
    370                 375                 380                 

Arg Leu Tyr Ile Ala Pro Asp His Leu Phe Glu Ser Ser Glu Val Ala 
385                 390                 395                 400 

Ala Leu Val Glu Thr Ile Lys Leu Ala Leu Ser Asp Val Asp Gln Met 
                405                 410                 415     

Arg Gln Ala Leu Gly Lys Gln Gly Gln His Ala Asn Tyr Val Asp Leu 
            420                 425                 430         

Val Arg Tyr Gln Glu Thr Met Gln Thr Val Leu Gly Gly 
        435                 440                 445 

<210>   3629
<211>   1509
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3629
atgacaattt acaatataaa tttaggaatt ggttgggcta gtagcggtgt tgaatacgct   60
caagcctatc gtgctggtgt ttttcggaaa ttaaatctgt cctctaagtt tatctttaca   120
gatatgattt tagccgataa tattcagcac ttaacagcca atattggttt tgatgataat   180
caggttatct ggctttataa tcatttcaca gatatcaaaa ttgcacctac tagcgtgaca   240
gtggatgatg tcttggctta ctttggtggt gaagaaagtc acagagaaaa aaatggcaag   300
gttttacgtg tattcttttt tgaccaagat aagtttgtaa cctgttattt ggttgatgag   360
aacaaggact tggttcaaca tgccgagtat gtttttaagg gaaacctgat tcggaaggat   420
tacttttctt atacgcgtta ttgtagcgag tattttgctc ccaaggacaa tgttgcagtc   480
ttataccaac gaacttttta taatgaagac gggactccag tctatgatat cttgatgaat   540
caagggaagg aagaagttta tcatttcaag gataagattt tctatggaaa gcaagctttt   600
gtgcgtgcct ttatgaaatc tttgaatttg aataagtctg atttggtcat tctcgatagg   660
gagacaggta ttggacaggt tgtgtttgag gaagcacaga cagcacatct agcggtagtt   720
gttcatgcgg agcattatag tgaaaatgct acaaatgagg actatatcct ttggaataac   780
tattatgact atcagtttac caatgcagat aaggttgact tctttatcgt gtctactgat   840
agacaaaatg aagttctaca agagcaattt gccaaatata ctcagcatca gccaaagatt   900
gttaccattc ctgtaggcag tattgattcc ttgacagatt caagtcaagg gcgcaaacca   960
ttttcattga ttacggcttc acgtcttgcc aaagaaaagc acattgattg gcttgtgaaa   1020
gctgtgattg aagctcataa ggagttaccg gaactaacct ttgatatcta tggtagtggt   1080
ggagaagatt ctctgcttag agaaattatt gcaaatcatc aggcagagga ctatatccaa   1140
ctcaaggggc atgcggaact ttcgcagatt tatagccagt atgaggtcta cttaacggct   1200
tctaccagcg aaggatttgg tctgaccttg atggaagcta ttggttcagg tctacctcta   1260
attggttttg atgtgcctta tggtaatcag acctttatag aggatgggca aaatggttat   1320
ttgattccaa gttcatctga ccatgtagaa gaccaaatca agcaagctta tgccgctaag   1380
atttgtcaat tgtatcaaga aaatcgtttg gaagctatgc gtgcctattc ttaccaaatt   1440
gcagaaggct tcttgaccaa agaaatttta gaaaagtgga agaaaacagt agaggaggtg   1500
ctccatgat                                                           1509

<210>   3630
<211>   503
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, group 1
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903267 (1.E-10)

<400>   3630
Met Thr Ile Tyr Asn Ile Asn Leu Gly Ile Gly Trp Ala Ser Ser Gly 
1               5                   10                  15      

Val Glu Tyr Ala Gln Ala Tyr Arg Ala Gly Val Phe Arg Lys Leu Asn 
            20                  25                  30          

Leu Ser Ser Lys Phe Ile Phe Thr Asp Met Ile Leu Ala Asp Asn Ile 
        35                  40                  45              

Gln His Leu Thr Ala Asn Ile Gly Phe Asp Asp Asn Gln Val Ile Trp 
    50                  55                  60                  

Leu Tyr Asn His Phe Thr Asp Ile Lys Ile Ala Pro Thr Ser Val Thr 
65                  70                  75                  80  

Val Asp Asp Val Leu Ala Tyr Phe Gly Gly Glu Glu Ser His Arg Glu 
                85                  90                  95      

Lys Asn Gly Lys Val Leu Arg Val Phe Phe Phe Asp Gln Asp Lys Phe 
            100                 105                 110         

Val Thr Cys Tyr Leu Val Asp Glu Asn Lys Asp Leu Val Gln His Ala 
        115                 120                 125             

Glu Tyr Val Phe Lys Gly Asn Leu Ile Arg Lys Asp Tyr Phe Ser Tyr 
    130                 135                 140                 

Thr Arg Tyr Cys Ser Glu Tyr Phe Ala Pro Lys Asp Asn Val Ala Val 
145                 150                 155                 160 

Leu Tyr Gln Arg Thr Phe Tyr Asn Glu Asp Gly Thr Pro Val Tyr Asp 
                165                 170                 175     

Ile Leu Met Asn Gln Gly Lys Glu Glu Val Tyr His Phe Lys Asp Lys 
            180                 185                 190         

Ile Phe Tyr Gly Lys Gln Ala Phe Val Arg Ala Phe Met Lys Ser Leu 
        195                 200                 205             

Asn Leu Asn Lys Ser Asp Leu Val Ile Leu Asp Arg Glu Thr Gly Ile 
    210                 215                 220                 

Gly Gln Val Val Phe Glu Glu Ala Gln Thr Ala His Leu Ala Val Val 
225                 230                 235                 240 

Val His Ala Glu His Tyr Ser Glu Asn Ala Thr Asn Glu Asp Tyr Ile 
                245                 250                 255     

Leu Trp Asn Asn Tyr Tyr Asp Tyr Gln Phe Thr Asn Ala Asp Lys Val 
            260                 265                 270         

Asp Phe Phe Ile Val Ser Thr Asp Arg Gln Asn Glu Val Leu Gln Glu 
        275                 280                 285             

Gln Phe Ala Lys Tyr Thr Gln His Gln Pro Lys Ile Val Thr Ile Pro 
    290                 295                 300                 

Val Gly Ser Ile Asp Ser Leu Thr Asp Ser Ser Gln Gly Arg Lys Pro 
305                 310                 315                 320 

Phe Ser Leu Ile Thr Ala Ser Arg Leu Ala Lys Glu Lys His Ile Asp 
                325                 330                 335     

Trp Leu Val Lys Ala Val Ile Glu Ala His Lys Glu Leu Pro Glu Leu 
            340                 345                 350         

Thr Phe Asp Ile Tyr Gly Ser Gly Gly Glu Asp Ser Leu Leu Arg Glu 
        355                 360                 365             

Ile Ile Ala Asn His Gln Ala Glu Asp Tyr Ile Gln Leu Lys Gly His 
    370                 375                 380                 

Ala Glu Leu Ser Gln Ile Tyr Ser Gln Tyr Glu Val Tyr Leu Thr Ala 
385                 390                 395                 400 

Ser Thr Ser Glu Gly Phe Gly Leu Thr Leu Met Glu Ala Ile Gly Ser 
                405                 410                 415     

Gly Leu Pro Leu Ile Gly Phe Asp Val Pro Tyr Gly Asn Gln Thr Phe 
            420                 425                 430         

Ile Glu Asp Gly Gln Asn Gly Tyr Leu Ile Pro Ser Ser Ser Asp His 
        435                 440                 445             

Val Glu Asp Gln Ile Lys Gln Ala Tyr Ala Ala Lys Ile Cys Gln Leu 
    450                 455                 460                 

Tyr Gln Glu Asn Arg Leu Glu Ala Met Arg Ala Tyr Ser Tyr Gln Ile 
465                 470                 475                 480 

Ala Glu Gly Phe Leu Thr Lys Glu Ile Leu Glu Lys Trp Lys Lys Thr 
                485                 490                 495     

Val Glu Glu Val Leu His Asp 
            500             

<210>   3631
<211>   2370
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3631
gtgtttagac gtttaggtca agatttccag cttaggaaag tgaaaaagat tttaaagcag   60
attaatgccc tgaaaggcaa gatgtcctct ctttcggatc aagaattagt agctaaaaca   120
gtagagtttc gtcagcgtct ttccgaggga gaaagtctag acgatatttt ggttgaagct   180
tttgctgtgg tgcgtgaagc agataagcgg attttaggga tgtttcctta tgatgttcaa   240
gtcatgggag ctattgtcat gcactatgga aatgttgctg agatgaatac gggggaaggt   300
aagaccttga cagctaccat gcctgtctat ttgaacgctt tttcaggaga aggagtgatg   360
gttgtgactc ctaatgagta tttatcaaag cgtgatgccg aggaaatggg tcaagtttat   420
cgttttctag gattgaccat tggtgtacca tttacggaag atccaaagaa ggagatgaaa   480
gctgaagaaa agaagcttat ctatgcttcg gatatcatct acacaaccaa tagtaattta   540
ggttttgatt atctaaatga taacctagcc tcgaatgaag aaggtaagtt tttacgaccg   600
tttaactatg tgattattga tgaaattgat gatatcttgc ttgatagtgc acaaactcct   660
ctgattattg cgggttctcc tcgtgttcag tctaattact atgcgatcat tgatacactt   720
gtaacaacct tggtcgaagg agaggattat atctttaaag aggagaaaga ggaggtttgg   780
ctcactacta agggggccaa gtctgctgag aatttcctag ggattgataa tttatacaag   840
gaagagcatg cgtcttttgc tcgtcatttg gtttatgcga ttcgagctca taagctcttt   900
actaaagata aggactatat cattcgtgga aatgagatgg tactggttga taagggaaca   960
gggcgtctaa tggaaatgac taaacttcaa ggaggtctcc atcaggctat tgaagccaag   1020
gaacatgtca aattatctcc tgagacgcgg gctatggcct cgatcaccta tcagagtctt   1080
tttaagatgt ttaataagat atctggtatg acagggacag gtaaggtcgc ggaaaaagag   1140
tttattgaaa cttacaatat gtctgtagta cgcattccaa ccaatcgtcc gagacaacgg   1200
attgactatc cagataatct atatatcact ttacctgaaa aagtgtatgc atccttggag   1260
tacatcaagc aataccatgc taagggaaat cctttactcg tttttgtagg ctcagttgaa   1320
atgtctcaac tctattcgtc tctcttgttt cgtgaaggga ttgcccataa tgtcctaaat   1380
gctaataatg cggcgcgtga ggctcagatt atctccgagt caggtcagat gggggctgtg   1440
acagtggcta cctctatggc aggacgtggt acggatatca agcttggtaa aggagtcgca   1500
gagcttgggg gcttgattgt tattgggact gagcggatgg aaagtcagcg gatcgaccta   1560
caaattcgtg gccgttctgg tcgtcaggga gatcctggta tgagtaaatt ttttgtatcc   1620
ttagaggatg atgttatcaa gaaatttggt ccatcttggg tgcataaaaa gtacaaagac   1680
tatcaggttc aagatatgac tcaaccggaa gtattgaaag gtcgtaaata ccggaaacta   1740
gtcgaaaagg ctcagcatgc cagtgatagt gctggacgtt cagcacgtcg tcagactctg   1800
gagtatgctg aaagtatgaa tatacaacgg gatatagtct ataaagagag aaatcgtcta   1860
atagatggtt ctcgtgactt agaggatgtt gttgtggata tcattgagag atatacagaa   1920
gaggtagcgg ctgatcacta tgctagtcgt gaattattgt ttcactttat tgtgaccaat   1980
attagttttc atgttaaaga ggttccagat tatatagatg taactgacaa aactgcagtt   2040
cgtagcttta tgaagcaggt gattgataaa gaactttctg aaaagaaaga attacttaat   2100
caacatgact tatatgaaca gtttttacga ctttcactgc ttaaagccat tgatgacaac   2160
tgggtagagc aggtagacta tctacaacag ctatccatgg ctatcggtgg tcaatctgct   2220
agtcagaaaa atccaatcgt agagtactat caagaagcct acgcgggctt tgaagctatg   2280
aaagaacaga ttcatgcgga tatggtgcgt aatctcctga tggggctggt tgaggtcact   2340
ccaaaaggtg aaatcgtgac tcattttcca                                    2370

<210>   3632
<211>   790
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   preprotein translocase, SecA subunit (secA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903587 (0.E+01)

<400>   3632
Met Phe Arg Arg Leu Gly Gln Asp Phe Gln Leu Arg Lys Val Lys Lys 
1               5                   10                  15      

Ile Leu Lys Gln Ile Asn Ala Leu Lys Gly Lys Met Ser Ser Leu Ser 
            20                  25                  30          

Asp Gln Glu Leu Val Ala Lys Thr Val Glu Phe Arg Gln Arg Leu Ser 
        35                  40                  45              

Glu Gly Glu Ser Leu Asp Asp Ile Leu Val Glu Ala Phe Ala Val Val 
    50                  55                  60                  

Arg Glu Ala Asp Lys Arg Ile Leu Gly Met Phe Pro Tyr Asp Val Gln 
65                  70                  75                  80  

Val Met Gly Ala Ile Val Met His Tyr Gly Asn Val Ala Glu Met Asn 
                85                  90                  95      

Thr Gly Glu Gly Lys Thr Leu Thr Ala Thr Met Pro Val Tyr Leu Asn 
            100                 105                 110         

Ala Phe Ser Gly Glu Gly Val Met Val Val Thr Pro Asn Glu Tyr Leu 
        115                 120                 125             

Ser Lys Arg Asp Ala Glu Glu Met Gly Gln Val Tyr Arg Phe Leu Gly 
    130                 135                 140                 

Leu Thr Ile Gly Val Pro Phe Thr Glu Asp Pro Lys Lys Glu Met Lys 
145                 150                 155                 160 

Ala Glu Glu Lys Lys Leu Ile Tyr Ala Ser Asp Ile Ile Tyr Thr Thr 
                165                 170                 175     

Asn Ser Asn Leu Gly Phe Asp Tyr Leu Asn Asp Asn Leu Ala Ser Asn 
            180                 185                 190         

Glu Glu Gly Lys Phe Leu Arg Pro Phe Asn Tyr Val Ile Ile Asp Glu 
        195                 200                 205             

Ile Asp Asp Ile Leu Leu Asp Ser Ala Gln Thr Pro Leu Ile Ile Ala 
    210                 215                 220                 

Gly Ser Pro Arg Val Gln Ser Asn Tyr Tyr Ala Ile Ile Asp Thr Leu 
225                 230                 235                 240 

Val Thr Thr Leu Val Glu Gly Glu Asp Tyr Ile Phe Lys Glu Glu Lys 
                245                 250                 255     

Glu Glu Val Trp Leu Thr Thr Lys Gly Ala Lys Ser Ala Glu Asn Phe 
            260                 265                 270         

Leu Gly Ile Asp Asn Leu Tyr Lys Glu Glu His Ala Ser Phe Ala Arg 
        275                 280                 285             

His Leu Val Tyr Ala Ile Arg Ala His Lys Leu Phe Thr Lys Asp Lys 
    290                 295                 300                 

Asp Tyr Ile Ile Arg Gly Asn Glu Met Val Leu Val Asp Lys Gly Thr 
305                 310                 315                 320 

Gly Arg Leu Met Glu Met Thr Lys Leu Gln Gly Gly Leu His Gln Ala 
                325                 330                 335     

Ile Glu Ala Lys Glu His Val Lys Leu Ser Pro Glu Thr Arg Ala Met 
            340                 345                 350         

Ala Ser Ile Thr Tyr Gln Ser Leu Phe Lys Met Phe Asn Lys Ile Ser 
        355                 360                 365             

Gly Met Thr Gly Thr Gly Lys Val Ala Glu Lys Glu Phe Ile Glu Thr 
    370                 375                 380                 

Tyr Asn Met Ser Val Val Arg Ile Pro Thr Asn Arg Pro Arg Gln Arg 
385                 390                 395                 400 

Ile Asp Tyr Pro Asp Asn Leu Tyr Ile Thr Leu Pro Glu Lys Val Tyr 
                405                 410                 415     

Ala Ser Leu Glu Tyr Ile Lys Gln Tyr His Ala Lys Gly Asn Pro Leu 
            420                 425                 430         

Leu Val Phe Val Gly Ser Val Glu Met Ser Gln Leu Tyr Ser Ser Leu 
        435                 440                 445             

Leu Phe Arg Glu Gly Ile Ala His Asn Val Leu Asn Ala Asn Asn Ala 
    450                 455                 460                 

Ala Arg Glu Ala Gln Ile Ile Ser Glu Ser Gly Gln Met Gly Ala Val 
465                 470                 475                 480 

Thr Val Ala Thr Ser Met Ala Gly Arg Gly Thr Asp Ile Lys Leu Gly 
                485                 490                 495     

Lys Gly Val Ala Glu Leu Gly Gly Leu Ile Val Ile Gly Thr Glu Arg 
            500                 505                 510         

Met Glu Ser Gln Arg Ile Asp Leu Gln Ile Arg Gly Arg Ser Gly Arg 
        515                 520                 525             

Gln Gly Asp Pro Gly Met Ser Lys Phe Phe Val Ser Leu Glu Asp Asp 
    530                 535                 540                 

Val Ile Lys Lys Phe Gly Pro Ser Trp Val His Lys Lys Tyr Lys Asp 
545                 550                 555                 560 

Tyr Gln Val Gln Asp Met Thr Gln Pro Glu Val Leu Lys Gly Arg Lys 
                565                 570                 575     

Tyr Arg Lys Leu Val Glu Lys Ala Gln His Ala Ser Asp Ser Ala Gly 
            580                 585                 590         

Arg Ser Ala Arg Arg Gln Thr Leu Glu Tyr Ala Glu Ser Met Asn Ile 
        595                 600                 605             

Gln Arg Asp Ile Val Tyr Lys Glu Arg Asn Arg Leu Ile Asp Gly Ser 
    610                 615                 620                 

Arg Asp Leu Glu Asp Val Val Val Asp Ile Ile Glu Arg Tyr Thr Glu 
625                 630                 635                 640 

Glu Val Ala Ala Asp His Tyr Ala Ser Arg Glu Leu Leu Phe His Phe 
                645                 650                 655     

Ile Val Thr Asn Ile Ser Phe His Val Lys Glu Val Pro Asp Tyr Ile 
            660                 665                 670         

Asp Val Thr Asp Lys Thr Ala Val Arg Ser Phe Met Lys Gln Val Ile 
        675                 680                 685             

Asp Lys Glu Leu Ser Glu Lys Lys Glu Leu Leu Asn Gln His Asp Leu 
    690                 695                 700                 

Tyr Glu Gln Phe Leu Arg Leu Ser Leu Leu Lys Ala Ile Asp Asp Asn 
705                 710                 715                 720 

Trp Val Glu Gln Val Asp Tyr Leu Gln Gln Leu Ser Met Ala Ile Gly 
                725                 730                 735     

Gly Gln Ser Ala Ser Gln Lys Asn Pro Ile Val Glu Tyr Tyr Gln Glu 
            740                 745                 750         

Ala Tyr Ala Gly Phe Glu Ala Met Lys Glu Gln Ile His Ala Asp Met 
        755                 760                 765             

Val Arg Asn Leu Leu Met Gly Leu Val Glu Val Thr Pro Lys Gly Glu 
    770                 775                 780                 

Ile Val Thr His Phe Pro 
785                 790 

<210>   3633
<211>   438
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3633
atgattatta cacagagaca gtctattcat tggggagaag ttggtgggac ttatatgtat   60
ggaacaactg tatcttatta ccctgacaaa agtgttcgtc tgtataatcc tctattgcca   120
tctggtgaga ttctaaagac ttggttttct agtgtcaatt accaggctgc acgaacccaa   180
cctcagcttc ccttattaaa aagaaagcag gagtatcaac tatcactggt ttttgactgt   240
cagcctgaaa atggagttta taccaagata actttttttg accgctatgg tgatatttta   300
gaaaaaaagg tagaaaaagt gaaagatttc atatttactt atccagaaga tagttatact   360
tatcgagttt ctcttttaag tgctggattt gagtccttaa ctttttatca tttttctatc   420
aaggagatca gaagtgtt                                                 438

<210>   3634
<211>   146
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm

<400>   3634
Met Ile Ile Thr Gln Arg Gln Ser Ile His Trp Gly Glu Val Gly Gly 
1               5                   10                  15      

Thr Tyr Met Tyr Gly Thr Thr Val Ser Tyr Tyr Pro Asp Lys Ser Val 
            20                  25                  30          

Arg Leu Tyr Asn Pro Leu Leu Pro Ser Gly Glu Ile Leu Lys Thr Trp 
        35                  40                  45              

Phe Ser Ser Val Asn Tyr Gln Ala Ala Arg Thr Gln Pro Gln Leu Pro 
    50                  55                  60                  

Leu Leu Lys Arg Lys Gln Glu Tyr Gln Leu Ser Leu Val Phe Asp Cys 
65                  70                  75                  80  

Gln Pro Glu Asn Gly Val Tyr Thr Lys Ile Thr Phe Phe Asp Arg Tyr 
                85                  90                  95      

Gly Asp Ile Leu Glu Lys Lys Val Glu Lys Val Lys Asp Phe Ile Phe 
            100                 105                 110         

Thr Tyr Pro Glu Asp Ser Tyr Thr Tyr Arg Val Ser Leu Leu Ser Ala 
        115                 120                 125             

Gly Phe Glu Ser Leu Thr Phe Tyr His Phe Ser Ile Lys Glu Ile Arg 
    130                 135                 140                 

Ser Val 
145     

<210>   3635
<211>   1533
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3635
atgtcaaagg aacttaatat tttacagata ggacttgcca attgggaaaa tcactatgac   60
atacctgaaa atatgagttg gtattatttt tacccaaact catcaaaagc ccttcgtgaa   120
ataattgaaa aagaggatat taaccgtttt catgcagttt taatagaaga tggtcagtat   180
tccagagact tattttccta tgtaaaatat tttgaacctt atactttatt ttataaccag   240
aatctacaaa taaatgatag agaggttgtg gattttctaa aaaaacgatg tgcacaagca   300
attgattttt taagtcccca acaactaatc aatgatttaa gtaaatctct ttttggcggt   360
gggtatggtg ataaactctt tcctccgacg atacaagtca atccaaattt tacaggagct   420
atttcttatc aaggattgga ttatgtcagt ttggaaggtg agtttgggca agattttgcc   480
cagcttgcct attgggctta taatattatg gtgcaaaaaa cactccctat tgagttgtgg   540
cttgaatatg agaaggaagg caattgtgac tttcgtttag taatccgtaa aatgtggagt   600
gggtctgttg atgatttctt tgaagaagta atagtatctg aaaaagactt ggagcaagca   660
ctttttatgg atagtcgaga cggagactac tttctctcga tatctgttga agcaagaggt   720
cgtggaacta tcaaactagg taatcttcac caacgatgga gtcgaaaaca atttggtaag   780
tttgtacttg gtggaaatat cctacatgat tccaagcgtg atgaaataaa ctatttcttc   840
catccaggtg attttaaacc gcctttgact gtctattttg caggttatcg acctgcagaa   900
ggattcgagg gttactttat gatgaaaact cttggatgtc ccttcatttt attttctgat   960
ccacgtttag aggggggagc tttttatctc ggaacggatg agctagaggg aaaagtaaag   1020
gatacgatca ctcactatct tgattattta ggctttgatc ataaggattt gattttatca   1080
ggtctttcta tgggaacgtt tccggctctc tattatggtg cttcttttga accccatgcc   1140
atcatagttg gtaagccctt ggctaattta ggaactatag ctagtcgtgg acgtttggac   1200
gcaccgggtg tctctaactt agcttttgat tgtttaattc atcatacagg tgggacaagt   1260
tctcaagata tgacggagtt ggatcagcgt ttttggaaaa tttttaaaca agcaaatttt   1320
tcaaagacaa cctttggttt atcctatatg aaagatgaag aaatggatcc acaagcctat   1380
gaacaattag tgtcttatct gtgtaataca ggtgcgaaga ttttatctaa aggaactgct   1440
ggacgacaca atgatgatac agataccaat atttcttggt ttttgcactt ttatagaatg   1500
gtcttagaga ctggttttgg aagggagaaa aga                                1533

<210>   3636
<211>   511
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3636
Met Ser Lys Glu Leu Asn Ile Leu Gln Ile Gly Leu Ala Asn Trp Glu 
1               5                   10                  15      

Asn His Tyr Asp Ile Pro Glu Asn Met Ser Trp Tyr Tyr Phe Tyr Pro 
            20                  25                  30          

Asn Ser Ser Lys Ala Leu Arg Glu Ile Ile Glu Lys Glu Asp Ile Asn 
        35                  40                  45              

Arg Phe His Ala Val Leu Ile Glu Asp Gly Gln Tyr Ser Arg Asp Leu 
    50                  55                  60                  

Phe Ser Tyr Val Lys Tyr Phe Glu Pro Tyr Thr Leu Phe Tyr Asn Gln 
65                  70                  75                  80  

Asn Leu Gln Ile Asn Asp Arg Glu Val Val Asp Phe Leu Lys Lys Arg 
                85                  90                  95      

Cys Ala Gln Ala Ile Asp Phe Leu Ser Pro Gln Gln Leu Ile Asn Asp 
            100                 105                 110         

Leu Ser Lys Ser Leu Phe Gly Gly Gly Tyr Gly Asp Lys Leu Phe Pro 
        115                 120                 125             

Pro Thr Ile Gln Val Asn Pro Asn Phe Thr Gly Ala Ile Ser Tyr Gln 
    130                 135                 140                 

Gly Leu Asp Tyr Val Ser Leu Glu Gly Glu Phe Gly Gln Asp Phe Ala 
145                 150                 155                 160 

Gln Leu Ala Tyr Trp Ala Tyr Asn Ile Met Val Gln Lys Thr Leu Pro 
                165                 170                 175     

Ile Glu Leu Trp Leu Glu Tyr Glu Lys Glu Gly Asn Cys Asp Phe Arg 
            180                 185                 190         

Leu Val Ile Arg Lys Met Trp Ser Gly Ser Val Asp Asp Phe Phe Glu 
        195                 200                 205             

Glu Val Ile Val Ser Glu Lys Asp Leu Glu Gln Ala Leu Phe Met Asp 
    210                 215                 220                 

Ser Arg Asp Gly Asp Tyr Phe Leu Ser Ile Ser Val Glu Ala Arg Gly 
225                 230                 235                 240 

Arg Gly Thr Ile Lys Leu Gly Asn Leu His Gln Arg Trp Ser Arg Lys 
                245                 250                 255     

Gln Phe Gly Lys Phe Val Leu Gly Gly Asn Ile Leu His Asp Ser Lys 
            260                 265                 270         

Arg Asp Glu Ile Asn Tyr Phe Phe His Pro Gly Asp Phe Lys Pro Pro 
        275                 280                 285             

Leu Thr Val Tyr Phe Ala Gly Tyr Arg Pro Ala Glu Gly Phe Glu Gly 
    290                 295                 300                 

Tyr Phe Met Met Lys Thr Leu Gly Cys Pro Phe Ile Leu Phe Ser Asp 
305                 310                 315                 320 

Pro Arg Leu Glu Gly Gly Ala Phe Tyr Leu Gly Thr Asp Glu Leu Glu 
                325                 330                 335     

Gly Lys Val Lys Asp Thr Ile Thr His Tyr Leu Asp Tyr Leu Gly Phe 
            340                 345                 350         

Asp His Lys Asp Leu Ile Leu Ser Gly Leu Ser Met Gly Thr Phe Pro 
        355                 360                 365             

Ala Leu Tyr Tyr Gly Ala Ser Phe Glu Pro His Ala Ile Ile Val Gly 
    370                 375                 380                 

Lys Pro Leu Ala Asn Leu Gly Thr Ile Ala Ser Arg Gly Arg Leu Asp 
385                 390                 395                 400 

Ala Pro Gly Val Ser Asn Leu Ala Phe Asp Cys Leu Ile His His Thr 
                405                 410                 415     

Gly Gly Thr Ser Ser Gln Asp Met Thr Glu Leu Asp Gln Arg Phe Trp 
            420                 425                 430         

Lys Ile Phe Lys Gln Ala Asn Phe Ser Lys Thr Thr Phe Gly Leu Ser 
        435                 440                 445             

Tyr Met Lys Asp Glu Glu Met Asp Pro Gln Ala Tyr Glu Gln Leu Val 
    450                 455                 460                 

Ser Tyr Leu Cys Asn Thr Gly Ala Lys Ile Leu Ser Lys Gly Thr Ala 
465                 470                 475                 480 

Gly Arg His Asn Asp Asp Thr Asp Thr Asn Ile Ser Trp Phe Leu His 
                485                 490                 495     

Phe Tyr Arg Met Val Leu Glu Thr Gly Phe Gly Arg Glu Lys Arg 
            500                 505                 510     

<210>   3637
<211>   1578
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3637
atgtattatt ttattccagc ttggtatggg tcagaaagaa catggcatgc agatatcact   60
ccatggtatt tttctcattt tcgtctagag tttgatgata cctttcacca gattcggctc   120
tttcaagagc aagatataga ttctcgtcta ttagtattag cttaccagcc tcatctacgt   180
tattttttat atagacatgg tgtgttagaa atggatactt attccgtttt tgatgttatg   240
caagattttc ataatctcca tacccaagtt ttaagcatta gagatattga gtgggatgat   300
gactgtgaat ttatttatag tccctttacg attatcgttc aaaaaaatgg gaagaaattt   360
gctaaggttg aacatggagt tgaaggcttc atcagtgata tacagtattt tgaaccaaat   420
ggtcaaatac atatgcacca tatcgtggat gatcgtgggt ttgtatcgag cattatcttt   480
tttgaagatg ggcaagcagc ctatcaagaa tatctgaacc tcaagggaga gtggcaattc   540
agagagcgtt taaaagaagg aggacaggta gaagtcaatc caattttggg ttatcgcttt   600
aaaatgctta cctatcaaaa tatgggagat ctggtggcag aattttttga gaattatctg   660
caaacgtatg tgaaggatca ggatattttt atgcttcctt ctcattctca tcatgaccag   720
ttggtactag atcgtttacc tagtactaat cctaaactgt tgagtctgtt cattggacgt   780
aatcctcaag atacctttag ggatttagat gtaacttttg aaaaatcgga tttgattttg   840
gtggatagag aggatagttt acgattgttg caggagttgt atcctgaacg aatgcatcaa   900
tgttatcatt tatcatcttt tgacacccga ttacgattgg gacgaagcca aactaagaaa   960
gaatccatca tttattttca actggatttt gagcagggga ttgataatca agctctgctt   1020
caagtcttgt cctttgtcgc tgaaaataag gatactgagg tgatttttgg agcctttgct   1080
gctagtcagg agcaaatgaa tgaggttgaa gggattgttg agtctttcat ccaagaaaac   1140
attcaatccg aaaatctggg aaaggcgatt gattatggtg atgcagaaaa tcctctggaa   1200
gaaaatcaac accaggactt acgcttacag tttgttaact tgaatgatga gttagatttg   1260
ataaaaacac tagaatttgt ccgtttgatt gtggatttaa atagacatcc tcatctctac   1320
acacagattg ctgggattag tgcaggaatt cctcaaatca acctagttga aaccgtctat   1380
gttgaacatt taaaaaatgg ttatttgtta gcagatgtta cagaattttc taaggctgca   1440
cattattaca cagataggtt gaaggagtgg aatgagtcct tgatatattc aattgataag   1500
attaaggagc acacaggaca acaatttctt ggaaaattag agaaatggat agaggaggtt   1560
aaaaatgtca aaggaact                                                 1578

<210>   3638
<211>   526
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3638
Met Tyr Tyr Phe Ile Pro Ala Trp Tyr Gly Ser Glu Arg Thr Trp His 
1               5                   10                  15      

Ala Asp Ile Thr Pro Trp Tyr Phe Ser His Phe Arg Leu Glu Phe Asp 
            20                  25                  30          

Asp Thr Phe His Gln Ile Arg Leu Phe Gln Glu Gln Asp Ile Asp Ser 
        35                  40                  45              

Arg Leu Leu Val Leu Ala Tyr Gln Pro His Leu Arg Tyr Phe Leu Tyr 
    50                  55                  60                  

Arg His Gly Val Leu Glu Met Asp Thr Tyr Ser Val Phe Asp Val Met 
65                  70                  75                  80  

Gln Asp Phe His Asn Leu His Thr Gln Val Leu Ser Ile Arg Asp Ile 
                85                  90                  95      

Glu Trp Asp Asp Asp Cys Glu Phe Ile Tyr Ser Pro Phe Thr Ile Ile 
            100                 105                 110         

Val Gln Lys Asn Gly Lys Lys Phe Ala Lys Val Glu His Gly Val Glu 
        115                 120                 125             

Gly Phe Ile Ser Asp Ile Gln Tyr Phe Glu Pro Asn Gly Gln Ile His 
    130                 135                 140                 

Met His His Ile Val Asp Asp Arg Gly Phe Val Ser Ser Ile Ile Phe 
145                 150                 155                 160 

Phe Glu Asp Gly Gln Ala Ala Tyr Gln Glu Tyr Leu Asn Leu Lys Gly 
                165                 170                 175     

Glu Trp Gln Phe Arg Glu Arg Leu Lys Glu Gly Gly Gln Val Glu Val 
            180                 185                 190         

Asn Pro Ile Leu Gly Tyr Arg Phe Lys Met Leu Thr Tyr Gln Asn Met 
        195                 200                 205             

Gly Asp Leu Val Ala Glu Phe Phe Glu Asn Tyr Leu Gln Thr Tyr Val 
    210                 215                 220                 

Lys Asp Gln Asp Ile Phe Met Leu Pro Ser His Ser His His Asp Gln 
225                 230                 235                 240 

Leu Val Leu Asp Arg Leu Pro Ser Thr Asn Pro Lys Leu Leu Ser Leu 
                245                 250                 255     

Phe Ile Gly Arg Asn Pro Gln Asp Thr Phe Arg Asp Leu Asp Val Thr 
            260                 265                 270         

Phe Glu Lys Ser Asp Leu Ile Leu Val Asp Arg Glu Asp Ser Leu Arg 
        275                 280                 285             

Leu Leu Gln Glu Leu Tyr Pro Glu Arg Met His Gln Cys Tyr His Leu 
    290                 295                 300                 

Ser Ser Phe Asp Thr Arg Leu Arg Leu Gly Arg Ser Gln Thr Lys Lys 
305                 310                 315                 320 

Glu Ser Ile Ile Tyr Phe Gln Leu Asp Phe Glu Gln Gly Ile Asp Asn 
                325                 330                 335     

Gln Ala Leu Leu Gln Val Leu Ser Phe Val Ala Glu Asn Lys Asp Thr 
            340                 345                 350         

Glu Val Ile Phe Gly Ala Phe Ala Ala Ser Gln Glu Gln Met Asn Glu 
        355                 360                 365             

Val Glu Gly Ile Val Glu Ser Phe Ile Gln Glu Asn Ile Gln Ser Glu 
    370                 375                 380                 

Asn Leu Gly Lys Ala Ile Asp Tyr Gly Asp Ala Glu Asn Pro Leu Glu 
385                 390                 395                 400 

Glu Asn Gln His Gln Asp Leu Arg Leu Gln Phe Val Asn Leu Asn Asp 
                405                 410                 415     

Glu Leu Asp Leu Ile Lys Thr Leu Glu Phe Val Arg Leu Ile Val Asp 
            420                 425                 430         

Leu Asn Arg His Pro His Leu Tyr Thr Gln Ile Ala Gly Ile Ser Ala 
        435                 440                 445             

Gly Ile Pro Gln Ile Asn Leu Val Glu Thr Val Tyr Val Glu His Leu 
    450                 455                 460                 

Lys Asn Gly Tyr Leu Leu Ala Asp Val Thr Glu Phe Ser Lys Ala Ala 
465                 470                 475                 480 

His Tyr Tyr Thr Asp Arg Leu Lys Glu Trp Asn Glu Ser Leu Ile Tyr 
                485                 490                 495     

Ser Ile Asp Lys Ile Lys Glu His Thr Gly Gln Gln Phe Leu Gly Lys 
            500                 505                 510         

Leu Glu Lys Trp Ile Glu Glu Val Lys Asn Val Lys Gly Thr 
        515                 520                 525     

<210>   3639
<211>   1215
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3639
atgactaaga tttattcgtc aatagcagta aaaaaaggac tatttacctc atttctactg   60
tttatctatg tattgggaag tcgtattatt ctcccttttg ttgacctaaa tactaaagat   120
tttttaggag gttcaacagc ctatctagcc ttctcagccg ccctaacagg tgggaatcta   180
agaagtttat caattttttc tgttggatta tccccttgga tgtccgccat gattttatgg   240
cagatgtttt ctttttctaa acggttgggt ttaacatcta cgtctataga aatacaagat   300
cgccgtaaaa tgtacctgac cttgctaatt gctgtgattc aatccttggc agttagcttg   360
agactgccag tacaatcctc ctattctgca atattggttg ttctaatgaa tacaatattg   420
ctgatagcag gaacattttt tcttgtttgg ttgtcagatt taaatgcgag tatggggatt   480
ggaggttcta ttgtaatcct cctatccagt atggttttaa atattcctca ggatgttttg   540
gaaacatttc agacagtaca cattccaaca gggattattg tgttacttgc tttattaacc   600
cttgtctttt cttatttact tgcccttatg tatcgagctc gctatttggt tcctgttaat   660
aaaattggct tacacaatcg atttaaacgc tattcttatc tcgaaatcat gttgaatcct   720
gcaggtggga tgccttatat gtatgtgatg agttttctta gtgtaccagc ttatttgttc   780
atcttgttgg gatttatttt ccctaatcat tcagggttag cggctttatc aaaggaattt   840
atggttggaa agcctttgtg ggtctatgtt tatatttcgg tcttattttt atttagtatc   900
atttttgctt ttgttacgat gaatggagaa gagattgcag accgtatgaa aaaatctgga   960
gaatacattt atggtattta tccaggtgcg gatactagtc gatttattaa tcgattggtc   1020
cttcgtttct cagtcatagg tggtctcttt aatgtgatta tggcaggtgg tcccatgctt   1080
tttgttttgt ttgatgaaaa gttattacga ttggcaatga ttccaggctt atttatgatg   1140
ttcgggggca tgatttttac gattagagac gaggtcaagg ctttaaggct aaatgagacc   1200
tatagacctt tgatt                                                    1215

<210>   3640
<211>   405
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   preprotein translocase SecY family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902253 (5.E-35)

<400>   3640
Met Thr Lys Ile Tyr Ser Ser Ile Ala Val Lys Lys Gly Leu Phe Thr 
1               5                   10                  15      

Ser Phe Leu Leu Phe Ile Tyr Val Leu Gly Ser Arg Ile Ile Leu Pro 
            20                  25                  30          

Phe Val Asp Leu Asn Thr Lys Asp Phe Leu Gly Gly Ser Thr Ala Tyr 
        35                  40                  45              

Leu Ala Phe Ser Ala Ala Leu Thr Gly Gly Asn Leu Arg Ser Leu Ser 
    50                  55                  60                  

Ile Phe Ser Val Gly Leu Ser Pro Trp Met Ser Ala Met Ile Leu Trp 
65                  70                  75                  80  

Gln Met Phe Ser Phe Ser Lys Arg Leu Gly Leu Thr Ser Thr Ser Ile 
                85                  90                  95      

Glu Ile Gln Asp Arg Arg Lys Met Tyr Leu Thr Leu Leu Ile Ala Val 
            100                 105                 110         

Ile Gln Ser Leu Ala Val Ser Leu Arg Leu Pro Val Gln Ser Ser Tyr 
        115                 120                 125             

Ser Ala Ile Leu Val Val Leu Met Asn Thr Ile Leu Leu Ile Ala Gly 
    130                 135                 140                 

Thr Phe Phe Leu Val Trp Leu Ser Asp Leu Asn Ala Ser Met Gly Ile 
145                 150                 155                 160 

Gly Gly Ser Ile Val Ile Leu Leu Ser Ser Met Val Leu Asn Ile Pro 
                165                 170                 175     

Gln Asp Val Leu Glu Thr Phe Gln Thr Val His Ile Pro Thr Gly Ile 
            180                 185                 190         

Ile Val Leu Leu Ala Leu Leu Thr Leu Val Phe Ser Tyr Leu Leu Ala 
        195                 200                 205             


Leu Met Tyr Arg Ala Arg Tyr Leu Val Pro Val Asn Lys Ile Gly Leu 
    210                 215                 220                 

His Asn Arg Phe Lys Arg Tyr Ser Tyr Leu Glu Ile Met Leu Asn Pro 
225                 230                 235                 240 

Ala Gly Gly Met Pro Tyr Met Tyr Val Met Ser Phe Leu Ser Val Pro 
                245                 250                 255     

Ala Tyr Leu Phe Ile Leu Leu Gly Phe Ile Phe Pro Asn His Ser Gly 
            260                 265                 270         

Leu Ala Ala Leu Ser Lys Glu Phe Met Val Gly Lys Pro Leu Trp Val 
        275                 280                 285             

Tyr Val Tyr Ile Ser Val Leu Phe Leu Phe Ser Ile Ile Phe Ala Phe 
    290                 295                 300                 

Val Thr Met Asn Gly Glu Glu Ile Ala Asp Arg Met Lys Lys Ser Gly 
305                 310                 315                 320 

Glu Tyr Ile Tyr Gly Ile Tyr Pro Gly Ala Asp Thr Ser Arg Phe Ile 
                325                 330                 335     

Asn Arg Leu Val Leu Arg Phe Ser Val Ile Gly Gly Leu Phe Asn Val 
            340                 345                 350         

Ile Met Ala Gly Gly Pro Met Leu Phe Val Leu Phe Asp Glu Lys Leu 
        355                 360                 365             

Leu Arg Leu Ala Met Ile Pro Gly Leu Phe Met Met Phe Gly Gly Met 
    370                 375                 380                 

Ile Phe Thr Ile Arg Asp Glu Val Lys Ala Leu Arg Leu Asn Glu Thr 
385                 390                 395                 400 

Tyr Arg Pro Leu Ile 
                405 

<210>   3641
<211>   903
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3641
atgagtgaat taattagtgt tgtggtaccg atatacaata cgggaaaata tttagtggag   60
tgtgtcgagc atattctgaa gcaaacctat caaaatatag aaattatttt agttgatgac   120
ggttctacgg ataattctgg ggaaatttgt gatgctttta tgatgcaaga taatcgtgtg   180
cgagtattgc atcaagaaaa taaggggggg gcagcacaag ctaaaaatat ggggattagt   240
gtagctaagg gagagtacat cacgattgtt gattcagatg atatcgtaaa agaaaatatg   300
attgaaactc tttatcagca agtccaagaa aaggatgcag atgttgttat agggaattac   360
tataattatg acgaaagtga cgggaatttt tatttttatg taacagggca agatttttgc   420
gtcgaagaat tagctataca agaaattatg aaccgtcaag caggagattg gaaattcaat   480
agctcggcct ttatattgcc gacatttaag ttgattaaaa aagaattatt caatgaagtt   540
cacttttcaa atggtcgccg ctttgatgat gaagcaacta tgcatcgctt ttatctttta   600
gcctctaaaa tcgtctttat aaacgataat ctctatctgt atagaagacg ttcaggaagc   660
atcatgagaa cggaatttga tctttcctgg gcaagagata ttgttgaagt gttttctaag   720
aaaatatcgg attgtgtctt ggctggtttg gatgtctccg ttctgcgtat tcgatttgtc   780
aatcttttaa aagattataa gcaaacttta gaataccatc aattaacaga tactgaggaa   840
tataaagata tttgtttcag attaaagttg ttttttgatg cagaacaaag aaatggtaaa   900
agt                                                                 903

<210>   3642
<211>   301
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903266 (2.E-37)

<400>   3642
Met Ser Glu Leu Ile Ser Val Val Val Pro Ile Tyr Asn Thr Gly Lys 
1               5                   10                  15      

Tyr Leu Val Glu Cys Val Glu His Ile Leu Lys Gln Thr Tyr Gln Asn 
            20                  25                  30          

Ile Glu Ile Ile Leu Val Asp Asp Gly Ser Thr Asp Asn Ser Gly Glu 
        35                  40                  45              

Ile Cys Asp Ala Phe Met Met Gln Asp Asn Arg Val Arg Val Leu His 
    50                  55                  60                  

Gln Glu Asn Lys Gly Gly Ala Ala Gln Ala Lys Asn Met Gly Ile Ser 
65                  70                  75                  80  

Val Ala Lys Gly Glu Tyr Ile Thr Ile Val Asp Ser Asp Asp Ile Val 
                85                  90                  95      

Lys Glu Asn Met Ile Glu Thr Leu Tyr Gln Gln Val Gln Glu Lys Asp 
            100                 105                 110         

Ala Asp Val Val Ile Gly Asn Tyr Tyr Asn Tyr Asp Glu Ser Asp Gly 
        115                 120                 125             

Asn Phe Tyr Phe Tyr Val Thr Gly Gln Asp Phe Cys Val Glu Glu Leu 
    130                 135                 140                 

Ala Ile Gln Glu Ile Met Asn Arg Gln Ala Gly Asp Trp Lys Phe Asn 
145                 150                 155                 160 

Ser Ser Ala Phe Ile Leu Pro Thr Phe Lys Leu Ile Lys Lys Glu Leu 
                165                 170                 175     

Phe Asn Glu Val His Phe Ser Asn Gly Arg Arg Phe Asp Asp Glu Ala 
            180                 185                 190         

Thr Met His Arg Phe Tyr Leu Leu Ala Ser Lys Ile Val Phe Ile Asn 
        195                 200                 205             

Asp Asn Leu Tyr Leu Tyr Arg Arg Arg Ser Gly Ser Ile Met Arg Thr 
    210                 215                 220                 

Glu Phe Asp Leu Ser Trp Ala Arg Asp Ile Val Glu Val Phe Ser Lys 
225                 230                 235                 240 

Lys Ile Ser Asp Cys Val Leu Ala Gly Leu Asp Val Ser Val Leu Arg 
                245                 250                 255     

Ile Arg Phe Val Asn Leu Leu Lys Asp Tyr Lys Gln Thr Leu Glu Tyr 
            260                 265                 270         

His Gln Leu Thr Asp Thr Glu Glu Tyr Lys Asp Ile Cys Phe Arg Leu 
        275                 280                 285             

Lys Leu Phe Phe Asp Ala Glu Gln Arg Asn Gly Lys Ser 
    290                 295                 300     

<210>   3643
<211>   1194
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3643
atgagaaaat caatagtatt agcggcagat aatgcctatc ttattccttt agagacgact   60
ataaagtctg tattgtatca caatagagat gttgattttt atattctcaa cagtgatata   120
gctcctgaat ggtttaaatt attggggaga aaaatggaag ttgtgaattc tacaattcgc   180
agtgtacaca ttgataaaga actttttgaa agctataaaa caggacctca tataaattat   240
gcttcttact ttagattttt tgcgacagaa gtggttgaat ctgatagggt attgtatctg   300
gattccgata tcattgtaac tggggaacta gctactttgt ttgagataga tctcaaagga   360
tattcaattg gtgctgttga tgatgtctat gcctatgaag gacgaaaatc tggatttaat   420
actggtatgt tactaatgga tgttgcaaag tggaaagaac attctattgt caatagttta   480
ttggaattag cggccgagca gaatcaagtt gttcatcttg gggatcagag tattttaaat   540
atttattttg aggataattg gctagcctta gataaaacat ataattatat ggtgggtatt   600
gatatttatc accttgctca agaatgtgaa cgtctagatg acaatccacc tacaattgtt   660
cactatgcta gtcatgataa accttggaat acatatagta tatctagact acgtgaatta   720
tggtgggttt atagagattt ggattggtca gagattgctt ttcaacgttc cgatttaaat   780
tattttgaaa gaagcaatca gtctaaaaaa caagtgatgc ttgtgacatg gagtgcagat   840
ataaaacatt tagagtattt agtacaacgg ttacctgatt ggcattttca tttggctgca   900
ccgtgtgatt gttctgagga gctgacctct ctatcacagt atacgaatgt aacagtatat   960
caaaatgtat tacatagtag aattgattgg ctattggacg attctatagt ttatttagat   1020
attaatacag gtggagaggt ttttaatgta gttacaaggg cacaagaaag tggcaagaaa   1080
atcttcgctt ttgatatcac acgtaaaagt atggatgatg gactctatga cggtattttt   1140
tctgtggaga gaccagatga tttagtggat agaatgaaga atatagagat agag         1194

<210>   3644
<211>   398
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 8
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902441 (8.E-31)

<400>   3644
Met Arg Lys Ser Ile Val Leu Ala Ala Asp Asn Ala Tyr Leu Ile Pro 
1               5                   10                  15      

Leu Glu Thr Thr Ile Lys Ser Val Leu Tyr His Asn Arg Asp Val Asp 
            20                  25                  30          

Phe Tyr Ile Leu Asn Ser Asp Ile Ala Pro Glu Trp Phe Lys Leu Leu 
        35                  40                  45              

Gly Arg Lys Met Glu Val Val Asn Ser Thr Ile Arg Ser Val His Ile 
    50                  55                  60                  

Asp Lys Glu Leu Phe Glu Ser Tyr Lys Thr Gly Pro His Ile Asn Tyr 
65                  70                  75                  80  

Ala Ser Tyr Phe Arg Phe Phe Ala Thr Glu Val Val Glu Ser Asp Arg 
                85                  90                  95      

Val Leu Tyr Leu Asp Ser Asp Ile Ile Val Thr Gly Glu Leu Ala Thr 
            100                 105                 110         

Leu Phe Glu Ile Asp Leu Lys Gly Tyr Ser Ile Gly Ala Val Asp Asp 
        115                 120                 125             

Val Tyr Ala Tyr Glu Gly Arg Lys Ser Gly Phe Asn Thr Gly Met Leu 
    130                 135                 140                 

Leu Met Asp Val Ala Lys Trp Lys Glu His Ser Ile Val Asn Ser Leu 
145                 150                 155                 160 

Leu Glu Leu Ala Ala Glu Gln Asn Gln Val Val His Leu Gly Asp Gln 
                165                 170                 175     

Ser Ile Leu Asn Ile Tyr Phe Glu Asp Asn Trp Leu Ala Leu Asp Lys 
            180                 185                 190         

Thr Tyr Asn Tyr Met Val Gly Ile Asp Ile Tyr His Leu Ala Gln Glu 
        195                 200                 205             

Cys Glu Arg Leu Asp Asp Asn Pro Pro Thr Ile Val His Tyr Ala Ser 
    210                 215                 220                 

His Asp Lys Pro Trp Asn Thr Tyr Ser Ile Ser Arg Leu Arg Glu Leu 
225                 230                 235                 240 

Trp Trp Val Tyr Arg Asp Leu Asp Trp Ser Glu Ile Ala Phe Gln Arg 
                245                 250                 255     

Ser Asp Leu Asn Tyr Phe Glu Arg Ser Asn Gln Ser Lys Lys Gln Val 
            260                 265                 270         

Met Leu Val Thr Trp Ser Ala Asp Ile Lys His Leu Glu Tyr Leu Val 
        275                 280                 285             

Gln Arg Leu Pro Asp Trp His Phe His Leu Ala Ala Pro Cys Asp Cys 
    290                 295                 300                 

Ser Glu Glu Leu Thr Ser Leu Ser Gln Tyr Thr Asn Val Thr Val Tyr 
305                 310                 315                 320 

Gln Asn Val Leu His Ser Arg Ile Asp Trp Leu Leu Asp Asp Ser Ile 
                325                 330                 335     

Val Tyr Leu Asp Ile Asn Thr Gly Gly Glu Val Phe Asn Val Val Thr 
            340                 345                 350         

Arg Ala Gln Glu Ser Gly Lys Lys Ile Phe Ala Phe Asp Ile Thr Arg 
        355                 360                 365             

Lys Ser Met Asp Asp Gly Leu Tyr Asp Gly Ile Phe Ser Val Glu Arg 
    370                 375                 380                 

Pro Asp Asp Leu Val Asp Arg Met Lys Asn Ile Glu Ile Glu 
385                 390                 395             

<210>   3645
<211>   1218
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3645
atgagaaata ccaaacgcgc tgtagtattt gcaggtgatt acgcttatat tcgacaaatc   60
gaaacggcga tgaagtcact ctgtagacac aatagtcatt tgaaaattta tctgctaaat   120
caggacattc ctcaggaatg gtttagtcaa ataagaatat atttacaaga gatggggggc   180
gacttgattg actgcaagtt aattggctca cagtttcaaa tgaattggtc taataaatta   240
cctcatatca atcatatgac atttgcacgc tattttattc cagattttgt aacagaagat   300
aaagttctct atctagatag tgatttgatt gtgactggtg atttgaccga tttgtttgaa   360
ttagacttag gtgaaaatta tttggcagca gctcgttctt gctttggagc aggagtcggc   420
ttcaatgctg gtgttctctt gattaacaac aaaaaatggg gatctgaaac tattcgacaa   480
aaattgattg acttaacaga aaaagaacat gagaatgtgg aagaaggaga ccagtcaatt   540
ttgaatatgt tgtttaaaga tcaatatagt tcccttgaag atcaatataa ttttcaaata   600
ggatatgatt atggggcggc aacctttaaa catcaattca tttttgatat tccgctcgaa   660
ccactgccac taattttaca ctatatttct caggataagc cttggaatca attttctgtt   720
ggacgtctaa gagaagtttg gtgggaatac tctttgatgg attggtctgt tattttaaat   780
gaatggtttt caaagagtgt gaagtaccct agtaaatcac aaatatttaa gttgcaatgt   840
gttaatttaa cgaattcttg gtgtgtcgag aaaatcgatt atttggcgga gcaattgcca   900
gaagttcatt ttcatattgt tgcttataca aatatggcaa atgaactact agctttaacg   960
cgttttccta atgttaccgt atatccaaat tccttaccaa tgttattgga acaaatagta   1020
atagcttcag atttgtattt ggatttgaat catgatcgaa aattagaaga tgcatatgag   1080
tttgtgctta agtacaaaaa accaatgata gctttcgaca atacttgctc tgaaaatctt   1140
tctgagattt catatgaagg tatctatcca agctccattc cgaaaaaaat ggttgcagca   1200
atcagatctt acatgagg                                                 1218

<210>   3646
<211>   406
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 8
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902441 (8.E-31)

<400>   3646
Met Arg Asn Thr Lys Arg Ala Val Val Phe Ala Gly Asp Tyr Ala Tyr 
1               5                   10                  15      

Ile Arg Gln Ile Glu Thr Ala Met Lys Ser Leu Cys Arg His Asn Ser 
            20                  25                  30          

His Leu Lys Ile Tyr Leu Leu Asn Gln Asp Ile Pro Gln Glu Trp Phe 
        35                  40                  45              

Ser Gln Ile Arg Ile Tyr Leu Gln Glu Met Gly Gly Asp Leu Ile Asp 
    50                  55                  60                  

Cys Lys Leu Ile Gly Ser Gln Phe Gln Met Asn Trp Ser Asn Lys Leu 
65                  70                  75                  80  

Pro His Ile Asn His Met Thr Phe Ala Arg Tyr Phe Ile Pro Asp Phe 
                85                  90                  95      

Val Thr Glu Asp Lys Val Leu Tyr Leu Asp Ser Asp Leu Ile Val Thr 
            100                 105                 110         


Gly Asp Leu Thr Asp Leu Phe Glu Leu Asp Leu Gly Glu Asn Tyr Leu 
        115                 120                 125             

Ala Ala Ala Arg Ser Cys Phe Gly Ala Gly Val Gly Phe Asn Ala Gly 
    130                 135                 140                 

Val Leu Leu Ile Asn Asn Lys Lys Trp Gly Ser Glu Thr Ile Arg Gln 
145                 150                 155                 160 

Lys Leu Ile Asp Leu Thr Glu Lys Glu His Glu Asn Val Glu Glu Gly 
                165                 170                 175     

Asp Gln Ser Ile Leu Asn Met Leu Phe Lys Asp Gln Tyr Ser Ser Leu 
            180                 185                 190         

Glu Asp Gln Tyr Asn Phe Gln Ile Gly Tyr Asp Tyr Gly Ala Ala Thr 
        195                 200                 205             

Phe Lys His Gln Phe Ile Phe Asp Ile Pro Leu Glu Pro Leu Pro Leu 
    210                 215                 220                 

Ile Leu His Tyr Ile Ser Gln Asp Lys Pro Trp Asn Gln Phe Ser Val 
225                 230                 235                 240 

Gly Arg Leu Arg Glu Val Trp Trp Glu Tyr Ser Leu Met Asp Trp Ser 
                245                 250                 255     

Val Ile Leu Asn Glu Trp Phe Ser Lys Ser Val Lys Tyr Pro Ser Lys 
            260                 265                 270         

Ser Gln Ile Phe Lys Leu Gln Cys Val Asn Leu Thr Asn Ser Trp Cys 
        275                 280                 285             

Val Glu Lys Ile Asp Tyr Leu Ala Glu Gln Leu Pro Glu Val His Phe 
    290                 295                 300                 

His Ile Val Ala Tyr Thr Asn Met Ala Asn Glu Leu Leu Ala Leu Thr 
305                 310                 315                 320 

Arg Phe Pro Asn Val Thr Val Tyr Pro Asn Ser Leu Pro Met Leu Leu 
                325                 330                 335     

Glu Gln Ile Val Ile Ala Ser Asp Leu Tyr Leu Asp Leu Asn His Asp 
            340                 345                 350         

Arg Lys Leu Glu Asp Ala Tyr Glu Phe Val Leu Lys Tyr Lys Lys Pro 
        355                 360                 365             

Met Ile Ala Phe Asp Asn Thr Cys Ser Glu Asn Leu Ser Glu Ile Ser 
    370                 375                 380                 

Tyr Glu Gly Ile Tyr Pro Ser Ser Ile Pro Lys Lys Met Val Ala Ala 
385                 390                 395                 400 

Ile Arg Ser Tyr Met Arg 
                405     

<210>   3647
<211>   2442
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3647
atgaacaaaa caattgtact agcaggggat cgcaattaca ccaggcagtt agaaacaacg   60
ataaaatcta ttttatacca caatcgagat gttaagattt atattttgaa tcaagatatc   120
atgccagatt ggtttcgcaa accacgaaaa atagctcgca tgttaggtag tgagattatc   180
gatgttaaac tacctgaaca aactgtgttt caagattggg aaaagcaaga tcacattagt   240
agcattactt atgctagata ttttattgca gattatatcc aagaagataa ggttttatat   300
ttagacagtg atttgattgt aaatacttct ttagagaaat tatttagtat ttgtttagaa   360
gaaaaatcac tcgcagcagt taaagataca gatggaatta catttaatgc aggtgtttta   420
ttaatcaaca ataaaaaatg gcgtcaagag aaattaaaag aacgactaat tgaacagagc   480
attgttacaa tgaaggaagt tgaagaaggc cgtttcgagc attttaatgg tgatcaaacg   540
atttttaatc aggtcttgca agatgattgg ttagaactag gtcgagctta taatttacaa   600
gtagggcatg atattgtggc tttgtataac aattggcagg aacatctggc ttttaatgat   660
aaaccagtgg tgattcattt tacgacctac agaaaaccct ggactacctt gacagccaat   720
cgttatcgtg atttatggtg ggaattccat gatttggagt ggagtcagat tttacaacac   780
catatgggag aatttgaact aatatcgcct ctagataagg aattttcttg cttaacctta   840
acgaattccc aagatttaga aggaatagaa gagctagtta cagctctacc tgaggtggta   900
tttcatatcg cagcttggac ggatatggga gataaattaa aaaaattagc tgtatataat   960
aatgtgagat tgcatccaca aattgttcca ccggtcttag ataagctgaa aaagtcaaca   1020
aatctatatt tggatatcaa tcatggtagt gcagatgaga actttttaaa atctttgcaa   1080
gaacaagaaa aaacgctact agcttttcaa tcgactcagc acggagagtt aggacaaatc   1140
gttttcgaaa atgggaaagt ttcctttatg attgatacga ttaaagattt taagaaaaac   1200
ggacatctta cctgttttcg acaacttcca agtttaactt gtttaacgtt tacggcttct   1260
cagtatatcg aacaattgga ttacttggct ggacagttgc caaatgttgt ttttcaaatt   1320
gctgcttgga cagctatggg gccaaaatta tatgatttgt ctaatcgtta tcctaatatt   1380
cagctctatc cggcaatttc tagagataag ctagacgagt tgaaggagaa gatggatgct   1440
tatttagata tcaacctact gacttcaaca tccgatatcg ttgcagaaat ggctcatcta   1500
tctaaaccta tactagcctt ttataaatct caaaatggga ataatggcca aaggttgtat   1560
tcaagtgaac atcctgaacg aatgttggct gatttgcaaa aattgataac taaggatatg   1620
ctagaaaaac cgcttgatat aatccaggtg aaagggatag atgaaacctt ggattatatt   1680
attgaacaca actcttcttt agttcgtttt ggagatgggg aaatcaatat gcttgcaggg   1740
cattcaattc cctaccagga ttatgatgaa gagttggttt caatcatgag ggacattatc   1800
ggccaagaaa gtcgagaaga tttagtagtg tgccttcctg atgcttttac agatcgtttt   1860
aggtttacat cgtgggcgat tccattttgg aaagatcaca tggatcatta tatggatttt   1920
tacagagagt tatgcagtga ttcatggtat ggctcaacct ttgtatctcg cccttatatc   1980
gattttgaag acaagagtca agctaaagct caatttgaaa aattgaaaag catttgggaa   2040
aaccgtgact tactgatagt cgaaggtgcg acttctcgtt caggtgtcgg aaatgattta   2100
ttcgatgagg caaattctat taagcgaatt atctgtcctt ctcatagtgc cttttctaga   2160
gttcatgaac ttgaacaaga aattgaaaag tatgctggtg gtcgcttgat tttatgtatg   2220
cttggaccta cagcaaaagt tctgagttat aatctatgcc agatgggcta tcaagttttg   2280
gatgtaggcc atattgactc agagtatgaa tggatgaaaa tgggagctaa aactaaggtt   2340
aaattttctc ataaacatac tgcagaacat aatttcgacc aagatattga atttattgat   2400
gatgaaacct ataacagtca gattgttgca cgaatattaa ac                      2442

<210>   3648
<211>   814
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 8
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902441 (8.E-27)

<400>   3648
Met Asn Lys Thr Ile Val Leu Ala Gly Asp Arg Asn Tyr Thr Arg Gln 
1               5                   10                  15      

Leu Glu Thr Thr Ile Lys Ser Ile Leu Tyr His Asn Arg Asp Val Lys 
            20                  25                  30          

Ile Tyr Ile Leu Asn Gln Asp Ile Met Pro Asp Trp Phe Arg Lys Pro 
        35                  40                  45              

Arg Lys Ile Ala Arg Met Leu Gly Ser Glu Ile Ile Asp Val Lys Leu 
    50                  55                  60                  

Pro Glu Gln Thr Val Phe Gln Asp Trp Glu Lys Gln Asp His Ile Ser 
65                  70                  75                  80  

Ser Ile Thr Tyr Ala Arg Tyr Phe Ile Ala Asp Tyr Ile Gln Glu Asp 
                85                  90                  95      

Lys Val Leu Tyr Leu Asp Ser Asp Leu Ile Val Asn Thr Ser Leu Glu 
            100                 105                 110         

Lys Leu Phe Ser Ile Cys Leu Glu Glu Lys Ser Leu Ala Ala Val Lys 
        115                 120                 125             

Asp Thr Asp Gly Ile Thr Phe Asn Ala Gly Val Leu Leu Ile Asn Asn 
    130                 135                 140                 

Lys Lys Trp Arg Gln Glu Lys Leu Lys Glu Arg Leu Ile Glu Gln Ser 
145                 150                 155                 160 

Ile Val Thr Met Lys Glu Val Glu Glu Gly Arg Phe Glu His Phe Asn 
                165                 170                 175     

Gly Asp Gln Thr Ile Phe Asn Gln Val Leu Gln Asp Asp Trp Leu Glu 
            180                 185                 190         

Leu Gly Arg Ala Tyr Asn Leu Gln Val Gly His Asp Ile Val Ala Leu 
        195                 200                 205             

Tyr Asn Asn Trp Gln Glu His Leu Ala Phe Asn Asp Lys Pro Val Val 
    210                 215                 220                 

Ile His Phe Thr Thr Tyr Arg Lys Pro Trp Thr Thr Leu Thr Ala Asn 
225                 230                 235                 240 

Arg Tyr Arg Asp Leu Trp Trp Glu Phe His Asp Leu Glu Trp Ser Gln 
                245                 250                 255     

Ile Leu Gln His His Met Gly Glu Phe Glu Leu Ile Ser Pro Leu Asp 
            260                 265                 270         

Lys Glu Phe Ser Cys Leu Thr Leu Thr Asn Ser Gln Asp Leu Glu Gly 
        275                 280                 285             

Ile Glu Glu Leu Val Thr Ala Leu Pro Glu Val Val Phe His Ile Ala 
    290                 295                 300                 

Ala Trp Thr Asp Met Gly Asp Lys Leu Lys Lys Leu Ala Val Tyr Asn 
305                 310                 315                 320 

Asn Val Arg Leu His Pro Gln Ile Val Pro Pro Val Leu Asp Lys Leu 
                325                 330                 335     

Lys Lys Ser Thr Asn Leu Tyr Leu Asp Ile Asn His Gly Ser Ala Asp 
            340                 345                 350         

Glu Asn Phe Leu Lys Ser Leu Gln Glu Gln Glu Lys Thr Leu Leu Ala 
        355                 360                 365             

Phe Gln Ser Thr Gln His Gly Glu Leu Gly Gln Ile Val Phe Glu Asn 
    370                 375                 380                 

Gly Lys Val Ser Phe Met Ile Asp Thr Ile Lys Asp Phe Lys Lys Asn 
385                 390                 395                 400 

Gly His Leu Thr Cys Phe Arg Gln Leu Pro Ser Leu Thr Cys Leu Thr 
                405                 410                 415     

Phe Thr Ala Ser Gln Tyr Ile Glu Gln Leu Asp Tyr Leu Ala Gly Gln 
            420                 425                 430         

Leu Pro Asn Val Val Phe Gln Ile Ala Ala Trp Thr Ala Met Gly Pro 
        435                 440                 445             

Lys Leu Tyr Asp Leu Ser Asn Arg Tyr Pro Asn Ile Gln Leu Tyr Pro 
    450                 455                 460                 

Ala Ile Ser Arg Asp Lys Leu Asp Glu Leu Lys Glu Lys Met Asp Ala 
465                 470                 475                 480 

Tyr Leu Asp Ile Asn Leu Leu Thr Ser Thr Ser Asp Ile Val Ala Glu 
                485                 490                 495     

Met Ala His Leu Ser Lys Pro Ile Leu Ala Phe Tyr Lys Ser Gln Asn 
            500                 505                 510         

Gly Asn Asn Gly Gln Arg Leu Tyr Ser Ser Glu His Pro Glu Arg Met 
        515                 520                 525             

Leu Ala Asp Leu Gln Lys Leu Ile Thr Lys Asp Met Leu Glu Lys Pro 
    530                 535                 540                 

Leu Asp Ile Ile Gln Val Lys Gly Ile Asp Glu Thr Leu Asp Tyr Ile 
545                 550                 555                 560 

Ile Glu His Asn Ser Ser Leu Val Arg Phe Gly Asp Gly Glu Ile Asn 
                565                 570                 575     

Met Leu Ala Gly His Ser Ile Pro Tyr Gln Asp Tyr Asp Glu Glu Leu 
            580                 585                 590         

Val Ser Ile Met Arg Asp Ile Ile Gly Gln Glu Ser Arg Glu Asp Leu 
        595                 600                 605             

Val Val Cys Leu Pro Asp Ala Phe Thr Asp Arg Phe Arg Phe Thr Ser 
    610                 615                 620                 

Trp Ala Ile Pro Phe Trp Lys Asp His Met Asp His Tyr Met Asp Phe 
625                 630                 635                 640 

Tyr Arg Glu Leu Cys Ser Asp Ser Trp Tyr Gly Ser Thr Phe Val Ser 
                645                 650                 655     

Arg Pro Tyr Ile Asp Phe Glu Asp Lys Ser Gln Ala Lys Ala Gln Phe 
            660                 665                 670         

Glu Lys Leu Lys Ser Ile Trp Glu Asn Arg Asp Leu Leu Ile Val Glu 
        675                 680                 685             

Gly Ala Thr Ser Arg Ser Gly Val Gly Asn Asp Leu Phe Asp Glu Ala 
    690                 695                 700                 

Asn Ser Ile Lys Arg Ile Ile Cys Pro Ser His Ser Ala Phe Ser Arg 
705                 710                 715                 720 

Val His Glu Leu Glu Gln Glu Ile Glu Lys Tyr Ala Gly Gly Arg Leu 
                725                 730                 735     

Ile Leu Cys Met Leu Gly Pro Thr Ala Lys Val Leu Ser Tyr Asn Leu 
            740                 745                 750         

Cys Gln Met Gly Tyr Gln Val Leu Asp Val Gly His Ile Asp Ser Glu 
        755                 760                 765             

Tyr Glu Trp Met Lys Met Gly Ala Lys Thr Lys Val Lys Phe Ser His 
    770                 775                 780                 

Lys His Thr Ala Glu His Asn Phe Asp Gln Asp Ile Glu Phe Ile Asp 
785                 790                 795                 800 

Asp Glu Thr Tyr Asn Ser Gln Ile Val Ala Arg Ile Leu Asn 
                805                 810                 

<210>   3649
<211>   1008
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3649
atgaaactac atttaacaaa tttatacggc atggctggtg atagtacggt tatcttagct   60
caaaatgctg ttcaaaagat agctagtcaa ctgggattta gagaggttgg tatttatttt   120
tacaacattg cttcagatag tccttctgaa atgaataagc gtctggatgg tattatggcc   180
agtatctcta ttggggatat tttagtcttt cagtctccaa cctggaatgg ttttgaattt   240
gatcgtctct tgtttgataa gctaaaggat atgcaggtga aaattatttg ctttatccat   300
gatgttgttc ccctcatgtt tgatagtaac tattatctca tgaaagatta tctgtatatg   360
tataatctat cagatgtttt gatagtgccg tcagagagaa tgaaaacacg cctgatggaa   420
gaaggattga cgactaagaa gattcttgtt caagggatgt gggatcatcc tcatgattta   480
tccttataca cccctgcttt taaaaaagaa cttttttttg ctggaagttt agagcgtttt   540
ccagacttac aaaattggtc tcaagatacg cctttgagag tattttcaaa taaaggggaa   600
gctagttcta gtgctagaag tctcagcatc gaaggatgga aaaaagatga ggaattgttg   660
ctagaattat caaagggtgg atttggcctt gtctggggaa cccatcaaaa tgagggagaa   720
agtaaccaat actatacctt gaatatatct cataaggtga gtacctatct aacagcgggc   780
attccagtca ttgtaccaag tagcttgtca actgctaaat ttatagtaga tcaaggcttg   840
ggctttatgg cggatagtct ggaagaggtt catgagatag ttgataaaat gaatctacaa   900
gaatatcaag aaatgacgaa tcgtatcaag acctttagct atttgttaaa agagggctat   960
ttcactaaaa agttattggt agatgcaatc tatcacttgg gaattgat                1008

<210>   3650
<211>   336
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3650
Met Lys Leu His Leu Thr Asn Leu Tyr Gly Met Ala Gly Asp Ser Thr 
1               5                   10                  15      

Val Ile Leu Ala Gln Asn Ala Val Gln Lys Ile Ala Ser Gln Leu Gly 
            20                  25                  30          

Phe Arg Glu Val Gly Ile Tyr Phe Tyr Asn Ile Ala Ser Asp Ser Pro 
        35                  40                  45              

Ser Glu Met Asn Lys Arg Leu Asp Gly Ile Met Ala Ser Ile Ser Ile 
    50                  55                  60                  

Gly Asp Ile Leu Val Phe Gln Ser Pro Thr Trp Asn Gly Phe Glu Phe 
65                  70                  75                  80  

Asp Arg Leu Leu Phe Asp Lys Leu Lys Asp Met Gln Val Lys Ile Ile 
                85                  90                  95      

Cys Phe Ile His Asp Val Val Pro Leu Met Phe Asp Ser Asn Tyr Tyr 
            100                 105                 110         

Leu Met Lys Asp Tyr Leu Tyr Met Tyr Asn Leu Ser Asp Val Leu Ile 
        115                 120                 125             

Val Pro Ser Glu Arg Met Lys Thr Arg Leu Met Glu Glu Gly Leu Thr 
    130                 135                 140                 

Thr Lys Lys Ile Leu Val Gln Gly Met Trp Asp His Pro His Asp Leu 
145                 150                 155                 160 

Ser Leu Tyr Thr Pro Ala Phe Lys Lys Glu Leu Phe Phe Ala Gly Ser 
                165                 170                 175     

Leu Glu Arg Phe Pro Asp Leu Gln Asn Trp Ser Gln Asp Thr Pro Leu 
            180                 185                 190         

Arg Val Phe Ser Asn Lys Gly Glu Ala Ser Ser Ser Ala Arg Ser Leu 
        195                 200                 205             

Ser Ile Glu Gly Trp Lys Lys Asp Glu Glu Leu Leu Leu Glu Leu Ser 
    210                 215                 220                 

Lys Gly Gly Phe Gly Leu Val Trp Gly Thr His Gln Asn Glu Gly Glu 
225                 230                 235                 240 

Ser Asn Gln Tyr Tyr Thr Leu Asn Ile Ser His Lys Val Ser Thr Tyr 
                245                 250                 255     

Leu Thr Ala Gly Ile Pro Val Ile Val Pro Ser Ser Leu Ser Thr Ala 
            260                 265                 270         

Lys Phe Ile Val Asp Gln Gly Leu Gly Phe Met Ala Asp Ser Leu Glu 
        275                 280                 285             

Glu Val His Glu Ile Val Asp Lys Met Asn Leu Gln Glu Tyr Gln Glu 
    290                 295                 300                 

Met Thr Asn Arg Ile Lys Thr Phe Ser Tyr Leu Leu Lys Glu Gly Tyr 
305                 310                 315                 320 

Phe Thr Lys Lys Leu Leu Val Asp Ala Ile Tyr His Leu Gly Ile Asp 
                325                 330                 335     


<210>   3651
<211>   489
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   3651
gtgtatatga cttatgttac ggatccagat gattctctag aagtgataga aggtaaagca   60
attatggata gggaaggtgt cgaagaagtc agaaatggga actggactgt agctgtcttg   120
aagttattca agagagagtt actacaagat ttaccatttc ctataggaaa aattgcagag   180
gatacttact ggacatggaa ggtacttcta agagcttcga ggatagtcta tttgaatcgt   240
tgtgtttact ggtaccgtgt tggtttatct gatactttat cgaatacatg gagtgaaaag   300
cgtatgtatg atgaaattgg ggctagggaa gaaaagatag ctattttagc aagttcagac   360
tatgacttga ccaatcatat tttgatttat aaaaatagat tacaaagagt gatagcaaaa   420
ttagaagaac aaaatatgca gttcacagag atttacagaa gaatgatgga aaaattgtct   480
ttacttccg                                                           489

<210>   3652
<211>   163
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, putative, FRAMESHIFT

<400>   3652
Met Tyr Met Thr Tyr Val Thr Asp Pro Asp Asp Ser Leu Glu Val Ile 
1               5                   10                  15      

Glu Gly Lys Ala Ile Met Asp Arg Glu Gly Val Glu Glu Val Arg Asn 
            20                  25                  30          

Gly Asn Trp Thr Val Ala Val Leu Lys Leu Phe Lys Arg Glu Leu Leu 
        35                  40                  45              

Gln Asp Leu Pro Phe Pro Ile Gly Lys Ile Ala Glu Asp Thr Tyr Trp 
    50                  55                  60                  

Thr Trp Lys Val Leu Leu Arg Ala Ser Arg Ile Val Tyr Leu Asn Arg 
65                  70                  75                  80  

Cys Val Tyr Trp Tyr Arg Val Gly Leu Ser Asp Thr Leu Ser Asn Thr 
                85                  90                  95      

Trp Ser Glu Lys Arg Met Tyr Asp Glu Ile Gly Ala Arg Glu Glu Lys 
            100                 105                 110         

Ile Ala Ile Leu Ala Ser Ser Asp Tyr Asp Leu Thr Asn His Ile Leu 
        115                 120                 125             

Ile Tyr Lys Asn Arg Leu Gln Arg Val Ile Ala Lys Leu Glu Glu Gln 
    130                 135                 140                 

Asn Met Gln Phe Thr Glu Ile Tyr Arg Arg Met Met Glu Lys Leu Ser 
145                 150                 155                 160 

Leu Leu Pro 
            

<210>   3653
<211>   1218
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3653
atgttaatga atacaaaatc tatagttttt aatgcagata atgattatgt agataaatta   60
gaaactgcaa ttaaatctat ttgttgttat aataattgtt taaaatttta tgtatttaat   120
gatgatattg cgtcagagtg gtttttgatg atgaataagc gattgaagac tatacaatct   180
gaaatcgtta atgtaaagat tgtagatcat gttcttaaaa agtttcattt accgttaaag   240
aatttaagtt atgccacttt ctttcgttat tttataccta attttgtcaa agaaagtcgt   300
gctttatacc tagattctga catcattgtt acaggaagtt tagactattt atttgatata   360
gaactagatg gttatgcctt ggcagcagta gaagattctt ttggtgatgt tccttctacc   420
aattttaact ccggaatgtt attagttaat gtagatactt ggagagatga agatgcttgt   480
tcgaaactgt tagaactgac caatcaatat catgaaacag catatggaga tcaaggaatt   540
ttaaatatgt tattccatga tagatggaaa agattagacc gaaattttaa ttttatggtg   600
gggatggata gcgtcgcaca catagaagga aatcataaat ggtatgagat ttctgagttg   660
aaaaatggag atttacctag tgttatacat tatactgggg taaaaccttg ggaaataatt   720
tccaataatc gctttagaga agtttggtgg ttttataatc tgttagaatg gtctgatatt   780
ttattgagaa aagacattat tagtcgtagt ttcgaagaac ttgtatacag tcctaaagct   840
catacagcaa tttttacagc tagttgtgag atggagcatg tagaatattt gatagaaaat   900
ttaccagagg tacatttttc tatactagca catacatatt ttgcgtctag tgtcgttgct   960
ttattaagat atagcaatgt tacgatttat ccttgttttt ctccatttga ttatcgaaaa   1020
attttggata atttagattt ttatttagat attaatcatt ataaagaagt ggataatatt   1080
gtatccgttg ttcaacaact atctaaacca atttttacct ttgaaaatac tagtcatgat   1140
ataggcaatc aaactaatat attttcttca accgaaccaa acaaaatggt agaggctatt   1200
agacaattta taggagaa                                                 1218

<210>   3654
<211>   406
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 8
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902441 (3.E-46)

<400>   3654
Met Leu Met Asn Thr Lys Ser Ile Val Phe Asn Ala Asp Asn Asp Tyr 
1               5                   10                  15      


Val Asp Lys Leu Glu Thr Ala Ile Lys Ser Ile Cys Cys Tyr Asn Asn 
            20                  25                  30          

Cys Leu Lys Phe Tyr Val Phe Asn Asp Asp Ile Ala Ser Glu Trp Phe 
        35                  40                  45              

Leu Met Met Asn Lys Arg Leu Lys Thr Ile Gln Ser Glu Ile Val Asn 
    50                  55                  60                  

Val Lys Ile Val Asp His Val Leu Lys Lys Phe His Leu Pro Leu Lys 
65                  70                  75                  80  

Asn Leu Ser Tyr Ala Thr Phe Phe Arg Tyr Phe Ile Pro Asn Phe Val 
                85                  90                  95      

Lys Glu Ser Arg Ala Leu Tyr Leu Asp Ser Asp Ile Ile Val Thr Gly 
            100                 105                 110         

Ser Leu Asp Tyr Leu Phe Asp Ile Glu Leu Asp Gly Tyr Ala Leu Ala 
        115                 120                 125             

Ala Val Glu Asp Ser Phe Gly Asp Val Pro Ser Thr Asn Phe Asn Ser 
    130                 135                 140                 

Gly Met Leu Leu Val Asn Val Asp Thr Trp Arg Asp Glu Asp Ala Cys 
145                 150                 155                 160 

Ser Lys Leu Leu Glu Leu Thr Asn Gln Tyr His Glu Thr Ala Tyr Gly 
                165                 170                 175     

Asp Gln Gly Ile Leu Asn Met Leu Phe His Asp Arg Trp Lys Arg Leu 
            180                 185                 190         

Asp Arg Asn Phe Asn Phe Met Val Gly Met Asp Ser Val Ala His Ile 
        195                 200                 205             

Glu Gly Asn His Lys Trp Tyr Glu Ile Ser Glu Leu Lys Asn Gly Asp 
    210                 215                 220                 

Leu Pro Ser Val Ile His Tyr Thr Gly Val Lys Pro Trp Glu Ile Ile 
225                 230                 235                 240 

Ser Asn Asn Arg Phe Arg Glu Val Trp Trp Phe Tyr Asn Leu Leu Glu 
                245                 250                 255     

Trp Ser Asp Ile Leu Leu Arg Lys Asp Ile Ile Ser Arg Ser Phe Glu 
            260                 265                 270         

Glu Leu Val Tyr Ser Pro Lys Ala His Thr Ala Ile Phe Thr Ala Ser 
        275                 280                 285             

Cys Glu Met Glu His Val Glu Tyr Leu Ile Glu Asn Leu Pro Glu Val 
    290                 295                 300                 

His Phe Ser Ile Leu Ala His Thr Tyr Phe Ala Ser Ser Val Val Ala 
305                 310                 315                 320 

Leu Leu Arg Tyr Ser Asn Val Thr Ile Tyr Pro Cys Phe Ser Pro Phe 
                325                 330                 335     

Asp Tyr Arg Lys Ile Leu Asp Asn Leu Asp Phe Tyr Leu Asp Ile Asn 
            340                 345                 350         


His Tyr Lys Glu Val Asp Asn Ile Val Ser Val Val Gln Gln Leu Ser 
        355                 360                 365             

Lys Pro Ile Phe Thr Phe Glu Asn Thr Ser His Asp Ile Gly Asn Gln 
    370                 375                 380                 

Thr Asn Ile Phe Ser Ser Thr Glu Pro Asn Lys Met Val Glu Ala Ile 
385                 390                 395                 400 

Arg Gln Phe Ile Gly Glu 
                405     

<210>   3655
<211>   2088
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3655
ttgctagtgg atgataaaat aacagtcatt gtaccagtat acaatgtgga aaactatctg   60
aggaagtgcc tagatagtat tattactcaa acatataaaa atattgagat tgttgtcgtt   120
aatgatggtt ctacggatgc ttcaggtgaa atttgtaaag aattttcaga aatggatcac   180
cgaattctct atatagaaca agaaaatgct ggtctttctg ccgcacgaaa caccggtctg   240
aataatatgt ccggaaatta tgtgaccttt gtggactcgg atgattggat tgagcaagat   300
tatgtagaaa ctctatataa aaaaatagta gagtatcagg ctgatattgc agttggtaat   360
tattattctt tcaacgaaag tgaaggaatg ttctactttc atatattggg agactcctat   420
tatgagaaag tatatgataa tgtttctatc tttgagaact tgtatgaaac tcaagaaatg   480
aagagttttg ctttgatatc tgcttggggt aaactctata aggcaagatt gtttgagcag   540
ttgcgctttg acataggtaa attaggagaa gatggttacc tcaatcaaaa ggtatattta   600
ttatcagaaa aggtaattta tttaaataaa agtctttatg cttatcggat tagaaaaggt   660
agtttatcaa gagtttggac agaaaagtgg atgcacgctt tagttgatgc tatgtctgaa   720
cgtattacgc tactagctaa tatgggttat cctctagaga aacacttggc agtttatcgt   780
cagatgttgg aagtcagtct cgccaacggt caagctagtg gtttatctga cacagcaacg   840
tataaagagt ttgaaatgaa acaaaggctt ttaaatcagc tatcgagaca agaggaaagt   900
gaaaagaaag ccattgtcct cgcagcaaac tatggctatg tagaccaagt tttaacgaca   960
atcaagtcta tttgttatca taatcgttcg attcgttttt atctgattca tagcgatttt   1020
ccaaatgaat ggattaagca attaaataag cgcttagaga agtttgactc agaaattatt   1080
aattgtcggg taacttctga gcaaatttca tgttataaat cggatattag ttacacagtc   1140
tttttacgct atttcatagc tgatttcgtg caagaagaca aggccctcta cttggactgt   1200
gatctagttg taacgaaaaa tctggatgac ttgtttgcta cagacttaca agattatcct   1260
ttggctgctg ttagagattt tgggggcaga gcttattttg gtcaagaaat ctttaatgcc   1320
ggtgttctct tggtaaacaa tgctttttgg aaaaaagaga atatgaccca aaaattaatt   1380
gatgtaacca atgaatggca tgataaggtg gatcaggcag atcagagcat cttgaatatg   1440
ctttttgaac ataaatggtt ggaattggac tttgattata atcatattgt cattcataaa   1500
cagtttgctg attatcaatt gcctgagggt caggattatc ctgctattat tcactatctt   1560
tctcatcgga aaccgtggaa agatttggcg gcccaaacct atcgtgaagt ttggtggtac   1620
tatcatgggc ttgaatggac agaattggga caaaaccatc atttacatcc attacaaaga   1680
tctcacatct atccaataaa ggaacctttc acttgtctaa tctatactgc ctcagaccat   1740
attgaacaaa ttgagacatt ggttcaatcc ttgcctgata ttcagtttaa gatagcagct   1800
agagtaatag ttagtgatcg attggctcag atgacaattt atccaaacgt gactatattt   1860
aacggaattc actatttggt agatgtcgat aatgaattgg tagaaaccag tcaagtactt   1920
ttagatatta atcatggcga aaagacagaa gaaattctcg atcaatttgc taatcttggc   1980
aagcctatct tatcctttga aaatactaaa acctatgaag taggtcagga ggcatatgct   2040
gttgaccaag ttcaagcaat gattgaaaaa ttgagagaaa taagcaaa                2088

<210>   3656
<211>   696
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 2/glycosyl transferase family 8
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902441 (6.E-39)

<400>   3656
Met Leu Val Asp Asp Lys Ile Thr Val Ile Val Pro Val Tyr Asn Val 
1               5                   10                  15      

Glu Asn Tyr Leu Arg Lys Cys Leu Asp Ser Ile Ile Thr Gln Thr Tyr 
            20                  25                  30          

Lys Asn Ile Glu Ile Val Val Val Asn Asp Gly Ser Thr Asp Ala Ser 
        35                  40                  45              

Gly Glu Ile Cys Lys Glu Phe Ser Glu Met Asp His Arg Ile Leu Tyr 
    50                  55                  60                  

Ile Glu Gln Glu Asn Ala Gly Leu Ser Ala Ala Arg Asn Thr Gly Leu 
65                  70                  75                  80  

Asn Asn Met Ser Gly Asn Tyr Val Thr Phe Val Asp Ser Asp Asp Trp 
                85                  90                  95      

Ile Glu Gln Asp Tyr Val Glu Thr Leu Tyr Lys Lys Ile Val Glu Tyr 
            100                 105                 110         

Gln Ala Asp Ile Ala Val Gly Asn Tyr Tyr Ser Phe Asn Glu Ser Glu 
        115                 120                 125             

Gly Met Phe Tyr Phe His Ile Leu Gly Asp Ser Tyr Tyr Glu Lys Val 
    130                 135                 140                 

Tyr Asp Asn Val Ser Ile Phe Glu Asn Leu Tyr Glu Thr Gln Glu Met 
145                 150                 155                 160 

Lys Ser Phe Ala Leu Ile Ser Ala Trp Gly Lys Leu Tyr Lys Ala Arg 
                165                 170                 175     

Leu Phe Glu Gln Leu Arg Phe Asp Ile Gly Lys Leu Gly Glu Asp Gly 
            180                 185                 190         

Tyr Leu Asn Gln Lys Val Tyr Leu Leu Ser Glu Lys Val Ile Tyr Leu 
        195                 200                 205             

Asn Lys Ser Leu Tyr Ala Tyr Arg Ile Arg Lys Gly Ser Leu Ser Arg 
    210                 215                 220                 

Val Trp Thr Glu Lys Trp Met His Ala Leu Val Asp Ala Met Ser Glu 
225                 230                 235                 240 

Arg Ile Thr Leu Leu Ala Asn Met Gly Tyr Pro Leu Glu Lys His Leu 
                245                 250                 255     

Ala Val Tyr Arg Gln Met Leu Glu Val Ser Leu Ala Asn Gly Gln Ala 
            260                 265                 270         

Ser Gly Leu Ser Asp Thr Ala Thr Tyr Lys Glu Phe Glu Met Lys Gln 
        275                 280                 285             

Arg Leu Leu Asn Gln Leu Ser Arg Gln Glu Glu Ser Glu Lys Lys Ala 
    290                 295                 300                 

Ile Val Leu Ala Ala Asn Tyr Gly Tyr Val Asp Gln Val Leu Thr Thr 
305                 310                 315                 320 

Ile Lys Ser Ile Cys Tyr His Asn Arg Ser Ile Arg Phe Tyr Leu Ile 
                325                 330                 335     

His Ser Asp Phe Pro Asn Glu Trp Ile Lys Gln Leu Asn Lys Arg Leu 
            340                 345                 350         

Glu Lys Phe Asp Ser Glu Ile Ile Asn Cys Arg Val Thr Ser Glu Gln 
        355                 360                 365             

Ile Ser Cys Tyr Lys Ser Asp Ile Ser Tyr Thr Val Phe Leu Arg Tyr 
    370                 375                 380                 

Phe Ile Ala Asp Phe Val Gln Glu Asp Lys Ala Leu Tyr Leu Asp Cys 
385                 390                 395                 400 

Asp Leu Val Val Thr Lys Asn Leu Asp Asp Leu Phe Ala Thr Asp Leu 
                405                 410                 415     

Gln Asp Tyr Pro Leu Ala Ala Val Arg Asp Phe Gly Gly Arg Ala Tyr 
            420                 425                 430         

Phe Gly Gln Glu Ile Phe Asn Ala Gly Val Leu Leu Val Asn Asn Ala 
        435                 440                 445             

Phe Trp Lys Lys Glu Asn Met Thr Gln Lys Leu Ile Asp Val Thr Asn 
    450                 455                 460                 

Glu Trp His Asp Lys Val Asp Gln Ala Asp Gln Ser Ile Leu Asn Met 
465                 470                 475                 480 

Leu Phe Glu His Lys Trp Leu Glu Leu Asp Phe Asp Tyr Asn His Ile 
                485                 490                 495     

Val Ile His Lys Gln Phe Ala Asp Tyr Gln Leu Pro Glu Gly Gln Asp 
            500                 505                 510         

Tyr Pro Ala Ile Ile His Tyr Leu Ser His Arg Lys Pro Trp Lys Asp 
        515                 520                 525             

Leu Ala Ala Gln Thr Tyr Arg Glu Val Trp Trp Tyr Tyr His Gly Leu 
    530                 535                 540                 

Glu Trp Thr Glu Leu Gly Gln Asn His His Leu His Pro Leu Gln Arg 
545                 550                 555                 560 

Ser His Ile Tyr Pro Ile Lys Glu Pro Phe Thr Cys Leu Ile Tyr Thr 
                565                 570                 575     

Ala Ser Asp His Ile Glu Gln Ile Glu Thr Leu Val Gln Ser Leu Pro 
            580                 585                 590         

Asp Ile Gln Phe Lys Ile Ala Ala Arg Val Ile Val Ser Asp Arg Leu 
        595                 600                 605             

Ala Gln Met Thr Ile Tyr Pro Asn Val Thr Ile Phe Asn Gly Ile His 
    610                 615                 620                 

Tyr Leu Val Asp Val Asp Asn Glu Leu Val Glu Thr Ser Gln Val Leu 
625                 630                 635                 640 

Leu Asp Ile Asn His Gly Glu Lys Thr Glu Glu Ile Leu Asp Gln Phe 
                645                 650                 655     

Ala Asn Leu Gly Lys Pro Ile Leu Ser Phe Glu Asn Thr Lys Thr Tyr 
            660                 665                 670         

Glu Val Gly Gln Glu Ala Tyr Ala Val Asp Gln Val Gln Ala Met Ile 
        675                 680                 685             

Glu Lys Leu Arg Glu Ile Ser Lys 
    690                 695     

<210>   3657
<211>   13152
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3657
ttgtcttact cttcttcatc acgtttacgg cgtttcgcaa ccaatccaat acctgtaaca   60
gctgctagaa ctccaagtaa cacagatcca attgacgact cagtacctgt attaggcaat   120
tctttttggg atttacctgt cgatccagaa gtatttccaa cttgtgagtt cgaatggttt   180
gctgaatttg aaactgatgt acttgctgaa gctgacgcac ttgttgatgc tgaagctgaa   240
gcactggtgc ttgctgaggc cgaggcactg gtgcttgctg aagccgacgc actcgttgat   300
gctgaagctg acgcacttgt tgaggccgaa gctgaagcac ttgttgatgc tgaggctgac   360
gcactggtac ttgctgaagc tgaggcactg gtgcttgctg aggctgaggc gctggtactt   420
gctgaggctg acgcactggt gcttgctgaa gctgaggcgc tggtacttgc tgaagccgat   480
gcactcgttg atgctgaggc tgatgcacta gtacttgctg aggctgacgc actcgttgat   540
gccgattcag acgctgagat acttgctgag gctgaggcac tggttgatgc tgaagccgac   600
gcactggtgc ttgctgaagc cgatgcacta gtacttgctg aggctgacgc actcgttgat   660
gccgattcag acgctgagat acttgctgag gctgaggcac tcgttgatgc tgaagccgac   720
gcactggtgc ttgctgagac tgatgcactg gttgacgctg aagccgatgc actcgttgat   780
gctgatgctg atgcactcgt tgatgccgat tcagacgctg agatacttgc tgaggctgat   840
gcactggttg atgctgatgc tgatgcacta gtacttgctg aggctgacgc actcgttgat   900
gctgatgctg aggcacttgt tgatgccgaa gccgaagcac tggttgatgc tgaagctgac   960
gcacttgtgc ttgctgaagc tgacgcactg gtacttgctg aagccgaggc actggttgac   1020
gctgaggctg aagcacttgt tgaggctgaa gctgatgcac tggttgatgc tgaggctgaa   1080
gcacttgtac ttgctgaggc cgaggcgctt gttgatgcgg aagctgacgc actggttgat   1140
gcagattcag aagctgatgt gcttgctgag gctgacgcac tcgttgatgc tgactcagac   1200
gcactcgttg acgctgaagc cgaagcactg gtgcttgctg aagccgaggc acttgttgat   1260

gcggattcag aggcactggt tgacgctgag actgaagcac tcgttgatgc tgaagccgac   1320
gcactggtac ttgctgaagc tgaagcactt gttgatgctg aagctgatgc actcgttgat   1380
gctgaagccg acgcacttgt tgatgctgat tcagacgctg aggtacttgc tgaagccgac   1440
gcacttgtcg acgctgaggc tgacgcactg gtacttgctg aagctgaggc gcttgtcgac   1500
gctgaggctg aggcgctagt acttgctgaa gctgatgcac tagtacttgc tgaagcggac   1560
gcactcgttg atgctgaggc tgaggcgcta gtacttgctg aggctgacgc actggttgat   1620
gccgattcag atgcactggt tgaggccgac gcacttgtcg acgctgaggc tgaagcactg   1680
gtacttgctg aggctgacgc actggtactt gctgaagctg aggcgcttgt cgatgctgag   1740
gctgacgcac tggttgatgc agattcagaa gctgatgtgc ttgctgaggc tgacgtactc   1800
gttgatgctg actcagacgc actcgttgac gctgaagccg aagcacttgt tgacgctgat   1860
gctgaggcgc tagtacttgc tgaagcggac gcactcgttg atgccgattc agacgctgag   1920
atacttgctg aagctgaagc acttgttgat gctgaagctg atgcactcgt tgatgctgat   1980
tcagacgctg aggtacttgc tgaagccgac gcacttgtcg acgctgaggc tgacgcactg   2040
gtacttgctg aagctgaggc actggtgctt gctgaggctg aggcgctggt acttgctgag   2100
gctgacgcac tggtgcttgc tgaagctgag gcgctggtac ttgctgaagc cgatgcactc   2160
gttgatgctg atgctgatgc actagtactt gctgaggctg acgcactcgt tgatgccgat   2220
tcagacgctg agatacttgc tgaggctgag gcactggttg atgctgaagc cgacgcactg   2280
gtgcttgctg aagccgatgc actagtactt gctgaggctg acgcactcgt tgatgccgat   2340
tcagacgctg agatacttgc tgaggctgag gcactcgttg atgctgaagc cgacgcactg   2400
gtgcttgctg agactgatgc actggttgac gctgaagccg atgcactcgt tgatgctgat   2460
gctgatgcac tcgttgatgc cgattcagac gctgagatac ttgctgaggc tgatgcactg   2520
gttgatgctg atgctgatgc actagtactt gctgaggctg acgcactcgt tgatgctgat   2580
gctgaggcac ttgttgatgc cgaagccgaa gcactggttg atgctgaagc tgacgcactt   2640
gtgcttgctg aagctgacgc actggtactt gctgaagccg aggcactggt tgacgctgag   2700
gctgaagcac ttgttgaggc tgaagctgat gcactggttg atgctgaggc tgaagcactt   2760
gtacttgctg aggccgaggc gcttgttgat gcggaagctg acgcactggt tgatgcagat   2820
tcagaagctg atgtgcttgc tgaggctgac gcactcgttg atgctgactc agacgcactc   2880
gttgacgctg aagccgaagc actggtgctt gctgaagccg aggcacttgt tgatgcggat   2940
tcagaggcac tggttgacgc tgagactgaa gcactcgttg atgctgaagc cgacgcactg   3000
gtacttgctg aagctgaagc acttgttgat gctgaagctg atgcactcgt tgatgctgaa   3060
gccgacgcac ttgttgatgc tgattcagac gctgaggtac ttgctgaagc cgacgcactt   3120
gtcgacgctg aggctgacgc actggtactt gctgaagctg aggcgcttgt cgacgctgag   3180
gctgaggcgc tagtacttgc tgaagctgat gcactagtac ttgctgaagc ggacgcactc   3240
gttgatgctg aggctgaggc gctagtactt gctgaggctg acgcactggt tgatgccgat   3300
tcagatgcac tggttgaggc cgacgcactt gtcgacgctg aggctgaagc actggtactt   3360
gctgaggctg acgcactggt acttgctgaa gctgaggcgc ttgtcgatgc tgaggctgac   3420
gcactggttg atgcagattc agaagctgat gtgcttgctg aggctgacgt actcgttgat   3480
gctgactcag acgcactcgt tgacgctgaa gccgaagcac ttgttgacgc tgatgctgag   3540
gcgctagtac ttgctgaagc ggacgcactc gttgatgccg attcagacgc tgagatactt   3600
gctgaggctg aagcacttgt gcttgctgaa gccgaggcac ttgttgatgc tgattcagat   3660
gctgaggtac ttgctgaagc tgaggcactg gttgatgcgg attcagacgc gctggtgctt   3720
gctgaggccg acgcactggt gcttgctgag actgatgcac tcgttgatgc tgaagccgag   3780
gcacttgttg atgccgattc agacgctgag atacttgctg aggccgaggc gctggttgac   3840
gcggaagctg aagcacttgt tgacgctgag gctgaggcgc tagtacttgc tgaagccgag   3900
gcacttgttg atgcggaagc tgacgcactg gtacttgctg actctgatgc actggttgat   3960
gctgaagccg atgcactcgt tgatgctgaa gctgatgcac tagtacttgc tgaggctgac   4020
gcactggttg atgccgattc agatgcactg gttgaggccg acgcacttgt cgacgctgag   4080
gctgacgcac tggtacttgc tgaggctgac gcactggtac ttgctgaagc cgacgcactt   4140
gtcgacgctg aggctgacgc actggtactt gctgaagctg aggcgcttgt cgatgctgag   4200
gctgacgcac tggttgatgc agattcagaa gctgatgtgc ttgctgaggc tgacgcactc   4260
gttgatgctg actcagacgc actcgttgac gctgaagccg atgcacttgt tgacgctgag   4320
gctgaggcgc tagtacttgc tgaagcggac gcactcgttg atgctgaagc cgatgcactt   4380
gttgacgctg aggctgaggc gctagtactt gctgaagcgg acgcactcgt tgatgccgat   4440
tcagacgcac tcgttgacgc tgaagccgat gcacttgttg acgctgaggc tgaggcgcta   4500
gtacttgctg aagcggacgc actcgttgat gccgattcag acgctgagat acttgctgag   4560
gctgacgcac tggttgaggc tgaggctgag gcgctagtac ttgctgaagc cgacgcactg   4620
gtgcttgctg aagccgaggc acttgttgat gcggaagctg acgcactggt acttgctgac   4680
tctgatgcac tggttgacgc cgaagccgat gcactcgttg atgctgaagc tgatgcacta   4740
gtacttgctg aggctgacgc acttgtcgac gctgaggctg acgcactggt acttgctgaa   4800
gctgaggcgc ttgtcgacgc tgattcagat gctgatgtgc ttgctgaagc cgaggcactt   4860
gtcgatgctg aggctgaagc acttgttgat gctgagactg aagcactggt acttgctgaa   4920
gctgacgcac tggttgacgc tgaagccgag gcactggttg atgctgaagc cgatgcacta   4980
gtacttgctg aggctgacgc actggttgat gccgattcag atgcactggt tgaggccgac   5040
gcacttgtcg acgctgaggc tgaagcactg gtacttgctg aagctgaggc gcttgtcgat   5100
gctgaggctg acgcactggt tgaggccgat tcagaagctg aggtgcttgc tgaggctgac   5160
gtactcgttg atgctgactc agacgcactc gttgatgccg attcagacgc tgagatactt   5220
gctgaggctg acgcacttgt tgatgctgag gctgaagcac tggttgacgc tgaagctgac   5280
gtactcgttg atgctgaacc cgaggcgctt gtgcttgctg aagccgaagc actcgttgat   5340
gctgaggctg aggcgctggt tgaggccgat tcagaagctg aggtgcttgc tgaggccgag   5400
gcgctggttg aggccgattc agaagctgag gtgcttgctg aggccgaggc gctggttgat   5460
gctgaagctg aagcactggt acttgctgaa gccgaagcac tggttgacgc tgattcagat   5520
gctgatgtgc ttgctgaagc cgaggcactt gttgatgcgg aagctgacgc actggtactt   5580
gctgactctg atgcactggt tgacgccgaa gccgatgcac tcgttgatgc tgaagctgat   5640
gcactagtac ttgctgaggc tgacgcactg gttgatgccg attcagatgc actggttgag   5700
gccgacgcac ttgtcgacgc tgattcagat gctgatgtgc ttgctgaagc cgaggcactt   5760
gtcgatgctg aggctgaagc acttgttgat gctgagactg aagcactggt acttgctgaa   5820
gctgacgcac tggttgacgc tgaagccgag gcactggttg atgctgaagc cgatgcactc   5880
gttgatgctg aagctgatgc actagtactt gctgaggctg acgcactggt tgatgccgat   5940
tcagatgcac tggttgaggc cgacgcactt gtcgacgctg aggctgaagc actggtactt   6000
gctgaagctg aggcgcttgt cgatgctgag gctgacgcac tggttgatgc cgattcagaa   6060
gctgatgtgc ttgctgaggc tgacgtactc gttgatgctg actcagacgc actcgttgat   6120
gccgattcag acgctgagat acttgctgag gctgacgcac ttgtgcttgc tgaagccgac   6180
gcactggttg aggcggaagc tgacgctgag gtacttgcgc ttgctgaggc cgacgcactc   6240
gttgatgccg attcagacgc tgagatactt gctgaggctg acgcacttgt gcttgctgaa   6300
gcggacgcac tggttgaggc ggaagctgac gctgaggtac ttgcgcttgc tgaggccgac   6360
gcactcgttg atgctgaagc cgaagcactt gtcgacgctg aagccgacgc actggttgac   6420
gctgaagcgg acgcactggt tgatgcagat tcagaagctg atgtgcttgc tgaggctgac   6480
gcactcgttg atgctgaagc cgaagcactc gttgatgccg attcagacgc acttgtcgat   6540
gctgaagccg atgcactagt acttgctgaa gccgacgcac tggtgcttgc tgaagccgag   6600
gcacttgttg atgctgattc agaggcactg gttgacgctg agactgaagc actcgttgat   6660
gctgaagccg acgcactggt acttgctgaa gctgaagcac ttgttgatgc tgaagctgat   6720
gcactcgttg atgctgattc agacgctgag gtacttgctg aagccgacgc acttgtcgac   6780
gctgaggctg acgcactggt acttgctgaa gctgaggcac tggtgcttgc tgaggctgag   6840
gcgctggtac ttgctgaggc tgacgcactg gtgcttgctg aagctgaggc gctggtactt   6900
gctgaagccg atgcactcgt tgatgctgat gctgatgcac tagtacttgc tgaagcggac   6960
gcactcgttg atgctgaggc tgaggcgcta gtacttgctg aggctgacgc actggttgat   7020
gccgattcag atgcactggt tgaggccgac gcacttgtcg acgctgaggc tgaagcactg   7080
gtacttgctg aggctgacgc actggtactt gctgaagctg aggcgcttgt cgatgctgag   7140
gctgacgcac tggttgatgc agattcagaa gctgatgtgc ttgctgaggc tgacgtactc   7200
gttgatgctg actcagacgc actcgttgac gctgaagccg aagcacttgt tgacgctgat   7260
gctgaggcgc tagtacttgc tgaagcggac gcactcgttg atgccgattc agacgctgag   7320
atacttgctg aggctgaagc acttgtgctt gctgaagccg atgcacttgt tgatgctgat   7380
tcagatgctg aggtacttgc tgaagctgag gcactggttg atgcggattc agacgcgctg   7440
gtgcttgctg aggccgacgc actggtgctt gctgagactg atgcactcgt tgatgctgaa   7500
gccgaggcac ttgttgatgc cgattcagac gctgagatac ttgctgaggc cgaggcgctg   7560
gttgacgcgg aagctgaagc acttgttgac gctgaggctg aggcgctagt acttgctgaa   7620
gccgaggcac ttgttgatgc ggaagctgac gcactggtac ttgctgactc tgatgcactg   7680
gttgatgctg aagccgatgc actcgttgat gctgaagctg atgcactagt acttgctgag   7740
gctgacgcac tggttgatgc cgattcagat gcactggttg aggccgacgc acttgtcgac   7800
gctgaggctg acgcactggt acttgctgag gctgacgcac tggtacttgc tgaagccgac   7860
gcacttgtcg acgctgaggc tgacgcactg gtacttgctg aagctgaggc gcttgtcgat   7920
gctgaggctg acgcactggt tgatgcagat tcagaagctg atgtgcttgc tgaggctgac   7980
gcactcgttg atgctgactc agacgcactc gttgacgctg aagccgatgc acttgttgac   8040
gctgaggctg aggcgctagt acttgctgaa gcggacgcac tcgttgatgc tgaagccgat   8100
gcacttgttg acgctgaggc tgaggcgcta gtacttgctg aagcggacgc actcgttgat   8160
gccgattcag acgcactcgt tgacgctgaa gccgatgcac ttgttgacgc tgaggctgag   8220
gcgctagtac ttgctgaagc ggacgcactc gttgatgccg attcagacgc tgagatactt   8280
gctgaggctg acgcactggt tgaggctgag gctgaggcgc tagtacttgc tgaagccgac   8340
gcactggtgc ttgctgaagc cgaggcactt gttgatgcgg aagctgacgc actggtactt   8400
gctgactctg atgcactggt tgacgccgaa gccgatgcac tcgttgatgc tgaagctgat   8460
gcactagtac ttgctgaggc tgacgcactt gtcgacgctg aggctgacgc actggtactt   8520
gctgaagctg aggcgcttgt cgacgctgat tcagatgctg atgtgcttgc tgaagccgag   8580
gcacttgtcg atgctgaggc tgaagcactt gttgatgctg agactgaagc actggtactt   8640
gctgaagctg acgcactggt tgacgctgaa gccgaggcac tggttgatgc tgaagccgat   8700
gcactcgttg atgctgaagc tgatgcacta gtacttgctg aggctgacgc actggttgat   8760
gccgattcag atgcactggt tgaggccgac gcacttgtcg acgctgaggc tgaagcactg   8820
gtacttgctg aagctgaggc gcttgtcgat gctgaggctg acgcactggt tgatgcagat   8880
tcagaagctg atgtgcttgc tgaggctgac gtactcgttg atgctgactc agacgcactc   8940

gttgatgccg attcagacgc tgagatactt gctgaggctg acgcacttgt gcttgctgaa   9000
gccgacgcac tggttgaggc ggaagctgac gctgaggtac ttgcgcttgc tgaggccgac   9060
gcactcgttg atgctgaagc cgaagcactt gtcgacgctg aagccgacgc actggttgac   9120
gctgaagcgg acgcactggt tgatgcagat tcagaagctg atgtgcttgc tgaggctgac   9180
gcactcgttg atgctgaagc cgaagcactc gttgatgccg attcagacgc acttgtcgat   9240
gctgaagccg atgcactagt acttgctgaa gccgacgcac tggtgcttgc tgaagccgag   9300
gcacttgttg atgctgattc agaggcactg gttgacgctg agactgaagc actcgttgat   9360
gctgaagccg acgcactggt acttgctgaa gctgaagcac ttgttgatgc tgaagctgat   9420
gcactcgttg atgctgattc agacgctgag gtacttgctg aagccgacgc acttgtcgac   9480
gctgaggctg acgcactggt acttgctgaa gctgaggcac tggtgcttgc tgaggctgag   9540
gcgctggtac ttgctgaggc tgacgcactg gtgcttgctg aagctgaggc gctggtactt   9600
gctgaagccg atgcactcgt tgatgctgat gctgatgcac tagtacttgc tgaggctgac   9660
gcactcgttg atgccgattc agacgctgag atacttgctg aggctgaggc actggttgat   9720
gctgaagccg acgcactggt gcttgctgaa gccgatgcac tagtacttgc tgaggctgac   9780
gcactcgttg atgccgattc agacgctgag atacttgctg aggctgaggc actcgttgat   9840
gctgaagccg acgcactggt gcttgctgag actgatgcac tggttgacgc tgaagccgat   9900
gcactcgttg atgctgatgc tgatgcactc gttgatgccg attcagacgc tgagatactt   9960
gctgaggctg atgcactggt tgatgctgat gctgatgcac tagtacttgc tgaggctgac   10020
gcactcgttg atgctgatgc tgaggcactt gttgatgccg aagccgaagc actggttgat   10080
gctgaagctg acgcacttgt gcttgctgaa gctgacgcac tggtacttgc tgaagccgag   10140
gcactggttg acgctgaggc tgaagcactt gttgaggctg aagctgatgc actggttgat   10200
gctgaggctg aagcacttgt acttgctgag gccgaggcgc ttgttgatgc ggaagctgac   10260
gcactggttg atgcagattc agaagctgat gtgcttgctg aggctgacgc actcgttgat   10320
gctgactcag acgcactcgt tgacgctgaa gccgaagcac tggtgcttgc tgaagccgag   10380
gcacttgttg atgcggattc agaggcactg gttgacgctg agactgaagc actcgttgat   10440
gctgaagccg acgcactggt acttgctgaa gctgaagcac ttgttgatgc tgaagctgat   10500
gcactcgttg atgctgaagc cgacgcactt gttgatgctg attcagacgc tgaggtactt   10560
gctgaagccg acgcacttgt cgacgctgag gctgacgcac tggtacttgc tgaagctgag   10620
gcgcttgtcg acgctgaggc tgaggcgcta gtacttgctg aagctgatgc actagtactt   10680
gctgaagcgg acgcactcgt tgatgctgag gctgaggcgc tagtacttgc tgaggctgac   10740
gcactggttg atgccgattc agatgcactg gttgaggccg acgcacttgt cgacgctgag   10800
gctgaagcac tggtacttgc tgaggctgac gcactggtac ttgctgaagc tgaggcgctt   10860
gtcgatgctg aggctgacgc actggttgat gcagattcag aagctgatgt gcttgctgag   10920
gctgacgtac tcgttgatgc tgactcagac gcactcgttg acgctgaagc cgaagcactt   10980
gttgacgctg atgctgaggc gctagtactt gctgaagcgg acgcactcgt tgatgccgat   11040
tcagacgctg agatacttgc tgaggctgaa gcacttgtgc ttgctgaagc cgaggcactt   11100
gttgatgctg attcagatgc tgaggtactt gctgaagctg aggcactggt tgatgcggat   11160
tcagacgcgc tggtgcttgc tgaggccgac gcactggtgc ttgctgagac tgatgcactc   11220
gttgatgctg aagccgaggc acttgttgat gccgattcag acgctgagat acttgctgag   11280
gccgaggcgc tggttgacgc ggaagctgaa gcacttgttg acgctgaggc tgaggcgcta   11340
gtacttgctg aagccgaggc acttgttgat gcggaagctg acgcactggt acttgctgac   11400
tctgatgcac tggttgatgc tgaagccgat gcactcgttg atgctgaagc tgatgcacta   11460
gtacttgctg aggctgacgc actggttgat gccgattcag atgcactggt tgaggccgac   11520
gcacttgtcg acgctgaggc tgacgcactg gtacttgctg aggctgacgc actggtactt   11580
gctgaagccg acgcacttgt cgacgctgag gctgacgcac tggtacttgc tgaagctgag   11640
gcgcttgtcg atgctgaggc tgacgcactg gttgatgcag attcagaagc tgatgtgctt   11700
gctgaggctg acgcactcgt tgatgctgac tcagacgcac tcgttgacgc tgaagccgat   11760
gcacttgttg acgctgaggc tgaggcgcta gtacttgctg aagcggacgc actcgttgat   11820
gctgaagccg atgcacttgt tgacgctgag gctgaggcgc tagtacttgc tgaagcggac   11880
gcactcgttg atgccgattc agacgcactc gttgacgctg aagccgatgc acttgttgac   11940
gctgaggctg aggcgctagt acttgctgaa gcggacgcac tcgttgatgc cgattcagac   12000
gctgagatac ttgctgaggc tgacgcactg gttgaggctg aggctgaggc gctagtactt   12060
gctgaagccg acgcactggt gcttgctgaa gccgaggcac ttgttgatgc ggaagctgac   12120
gcactggtac ttgctgactc tgatgcactg gttgacgccg aagccgatgc actcgttgat   12180
gctgaagctg atgcactagt acttgctgag gctgacgcac ttgtcgacgc tgaggctgac   12240
gcactggtac ttgctgaagc tgaggcgctt gtcgacgctg attcagatgc tgatgtgctt   12300
gctgaagccg aggcacttgt cgatgctgag gctgaagcac ttgttgatgc tgagactgaa   12360
gcactggtac ttgctgaagc tgacgcactg gttgacgctg aagccgaggc actggttgat   12420
gctgaagccg atgcactagt acttgctgag gctgacgcac tggttgatgc cgattcagat   12480
gcactggttg aggccgacgc acttgtcgac gctgaggctg aagcactggt acttgctgaa   12540
gctgaggcgc ttgtcgatgc tgaggctgac gcactggttg aggccgattc agaagctgag   12600
gtgcttgctg aggctgacgt actcgttgat gctgactcag acgcactcgt tgatgccgat   12660
tcagacgctg agatacttgc tgaggctgac gcacttgttg atgctgaggc tgaagcactg   12720
gttgacgctg aagctgacgt actcgttgat gctgaacccg aggcgcttgt gcttgctgaa   12780
gccgaagcac tcgttgatgc tgaggctgag gcgctggttg aggccgattc agaagctgag   12840
gtgcttgctg aggccgaggc gctggttgag gccgattcag aagctgaggt gcttgctgag   12900
gccgaggcgc tggttgatgc tgaagctgaa gcactggtac ttgctgaagc cgaagcactg   12960
gttgacgctg attcagatgc tgatgtgctt gctgaagccg aggcacttgt cgatgctgag   13020
gctgaagcac ttgttgatgc tgagactgaa gcactggtac ttgctgaagc tgacgcactg   13080
gttgacgctg aagccgaggc actggttgat gctgaagccg acgcacttgt tgatgctgaa   13140
gctgaggcgc tt                                                       13152

<210>   3658
<211>   4384
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3658
Met Ser Tyr Ser Ser Ser Ser Arg Leu Arg Arg Phe Ala Thr Asn Pro 
1               5                   10                  15      

Ile Pro Val Thr Ala Ala Arg Thr Pro Ser Asn Thr Asp Pro Ile Asp 
            20                  25                  30          

Asp Ser Val Pro Val Leu Gly Asn Ser Phe Trp Asp Leu Pro Val Asp 
        35                  40                  45              

Pro Glu Val Phe Pro Thr Cys Glu Phe Glu Trp Phe Ala Glu Phe Glu 
    50                  55                  60                  

Thr Asp Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu 
65                  70                  75                  80  

Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp 
                85                  90                  95      

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Glu Ala Glu Ala Glu 
            100                 105                 110         

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu 
        115                 120                 125             

Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp 
    130                 135                 140                 

Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp 
145                 150                 155                 160 

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp 
                165                 170                 175     


Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu Ala Glu 
            180                 185                 190         

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp 
        195                 200                 205             

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp 
    210                 215                 220                 

Ala Glu Ile Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp 
225                 230                 235                 240 

Ala Leu Val Leu Ala Glu Thr Asp Ala Leu Val Asp Ala Glu Ala Asp 
                245                 250                 255     

Ala Leu Val Asp Ala Asp Ala Asp Ala Leu Val Asp Ala Asp Ser Asp 
            260                 265                 270         

Ala Glu Ile Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ala Asp 
        275                 280                 285             

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ala Glu 
    290                 295                 300                 

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp 
305                 310                 315                 320 

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu 
                325                 330                 335     

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Glu Ala Glu Ala Asp 
            340                 345                 350         

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Glu 
        355                 360                 365             

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Glu 
    370                 375                 380                 

Ala Asp Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp 
385                 390                 395                 400 

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Glu 
                405                 410                 415     

Ala Leu Val Asp Ala Asp Ser Glu Ala Leu Val Asp Ala Glu Thr Glu 
            420                 425                 430         

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu 
        435                 440                 445             

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp 
    450                 455                 460                 

Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Val Leu Ala Glu Ala Asp 
465                 470                 475                 480 

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu 
                485                 490                 495     

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp 
            500                 505                 510         


Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu 
        515                 520                 525             

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp 
    530                 535                 540                 

Ala Leu Val Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
545                 550                 555                 560 

Val Leu Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu 
                565                 570                 575     

Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Glu Ala Asp 
            580                 585                 590         

Val Leu Ala Glu Ala Asp Val Leu Val Asp Ala Asp Ser Asp Ala Leu 
        595                 600                 605             

Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Asp Ala Glu Ala Leu 
    610                 615                 620                 

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu 
625                 630                 635                 640 

Ile Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu 
                645                 650                 655     

Val Asp Ala Asp Ser Asp Ala Glu Val Leu Ala Glu Ala Asp Ala Leu 
            660                 665                 670         

Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu 
        675                 680                 685             

Val Leu Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu 
    690                 695                 700                 

Val Leu Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu 
705                 710                 715                 720 

Val Asp Ala Asp Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu 
                725                 730                 735     

Val Asp Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu Ala Glu Ala Leu 
            740                 745                 750         

Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu 
        755                 760                 765             

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu 
    770                 775                 780                 

Ile Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu 
785                 790                 795                 800 

Val Leu Ala Glu Thr Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu 
                805                 810                 815     

Val Asp Ala Asp Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu 
            820                 825                 830         

Ile Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ala Asp Ala Leu 
        835                 840                 845             

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ala Glu Ala Leu 
    850                 855                 860                 

Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu 
865                 870                 875                 880 

Val Leu Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu 
                885                 890                 895     

Val Asp Ala Glu Ala Glu Ala Leu Val Glu Ala Glu Ala Asp Ala Leu 
            900                 905                 910         

Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Glu Ala Leu 
        915                 920                 925             

Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Glu Ala Asp 
    930                 935                 940                 

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Leu 
945                 950                 955                 960 

Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Glu Ala Leu 
                965                 970                 975     

Val Asp Ala Asp Ser Glu Ala Leu Val Asp Ala Glu Thr Glu Ala Leu 
            980                 985                 990         

Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu 
        995                 1000                1005            

Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu 
    1010                1015                1020                

Val Asp Ala Asp Ser Asp Ala Glu Val Leu Ala Glu Ala Asp Ala Leu 
1025                1030                1035                1040

Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu 
                1045                1050                1055    

Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu 
            1060                1065                1070        

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
        1075                1080                1085            

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Leu 
    1090                1095                1100                

Val Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu 
1105                1110                1115                1120

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp 
                1125                1130                1135    

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Glu Ala Asp Val Leu 
            1140                1145                1150        

Ala Glu Ala Asp Val Leu Val Asp Ala Asp Ser Asp Ala Leu Val Asp 
        1155                1160                1165            

Ala Glu Ala Glu Ala Leu Val Asp Ala Asp Ala Glu Ala Leu Val Leu 
    1170                1175                1180                

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Ile Leu 
1185                1190                1195                1200

Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp 
                1205                1210                1215    

Ala Asp Ser Asp Ala Glu Val Leu Ala Glu Ala Glu Ala Leu Val Asp 
            1220                1225                1230        

Ala Asp Ser Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Leu 
        1235                1240                1245            

Ala Glu Thr Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp 
    1250                1255                1260                

Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu Ala Glu Ala Leu Val Asp 
1265                1270                1275                1280

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu 
                1285                1290                1295    

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu 
            1300                1305                1310        

Ala Asp Ser Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp 
        1315                1320                1325            

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
    1330                1335                1340                

Ala Asp Ser Asp Ala Leu Val Glu Ala Asp Ala Leu Val Asp Ala Glu 
1345                1350                1355                1360

Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Leu Ala Glu 

                1365                1370                1375    

Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu 
            1380                1385                1390        

Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Asp 
        1395                1400                1405            

Ser Glu Ala Asp Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp 
    1410                1415                1420                

Ser Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu 
1425                1430                1435                1440

Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu 
                1445                1450                1455    

Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu 
            1460                1465                1470        

Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Leu Val Asp Ala Glu 
        1475                1480                1485            

Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu 
    1490                1495                1500                

Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu 
1505                1510                1515                1520

Ala Asp Ala Leu Val Glu Ala Glu Ala Glu Ala Leu Val Leu Ala Glu 
                1525                1530                1535    

Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu 
            1540                1545                1550        

Ala Asp Ala Leu Val Leu Ala Asp Ser Asp Ala Leu Val Asp Ala Glu 
        1555                1560                1565            

Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu 
    1570                1575                1580                

Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu 
1585                1590                1595                1600

Ala Glu Ala Leu Val Asp Ala Asp Ser Asp Ala Asp Val Leu Ala Glu 
                1605                1610                1615    

Ala Glu Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Glu 
            1620                1625                1630        

Thr Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu 
        1635                1640                1645            

Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu 
    1650                1655                1660                

Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Leu Val Glu Ala Asp 
1665                1670                1675                1680

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Glu 
                1685                1690                1695    

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Glu Ala Asp Ser Glu 
            1700                1705                1710        

Ala Glu Val Leu Ala Glu Ala Asp Val Leu Val Asp Ala Asp Ser Asp 
        1715                1720                1725            

Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu Ala Asp 
    1730                1735                1740                

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp 
1745                1750                1755                1760

Val Leu Val Asp Ala Glu Pro Glu Ala Leu Val Leu Ala Glu Ala Glu 
                1765                1770                1775    

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Glu Ala Asp Ser Glu 
            1780                1785                1790        

Ala Glu Val Leu Ala Glu Ala Glu Ala Leu Val Glu Ala Asp Ser Glu 
        1795                1800                1805            

Ala Glu Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Glu 
    1810                1815                1820                

Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Asp Ser Asp 
1825                1830                1835                1840

Ala Asp Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp 
                1845                1850                1855    

Ala Leu Val Leu Ala Asp Ser Asp Ala Leu Val Asp Ala Glu Ala Asp 
            1860                1865                1870        

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp 
        1875                1880                1885            

Ala Leu Val Asp Ala Asp Ser Asp Ala Leu Val Glu Ala Asp Ala Leu 
    1890                1895                1900                

Val Asp Ala Asp Ser Asp Ala Asp Val Leu Ala Glu Ala Glu Ala Leu 
1905                1910                1915                1920

Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Thr Glu Ala Leu 
                1925                1930                1935    

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
            1940                1945                1950        

Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu 
        1955                1960                1965            

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Leu 
    1970                1975                1980                

Val Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu 
1985                1990                1995                2000

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp 
                2005                2010                2015    

Ala Asp Ser Glu Ala Asp Val Leu Ala Glu Ala Asp Val Leu Val Asp 
            2020                2025                2030        

Ala Asp Ser Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Ile Leu 
        2035                2040                2045            

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Glu 
    2050                2055                2060                

Ala Glu Ala Asp Ala Glu Val Leu Ala Leu Ala Glu Ala Asp Ala Leu 
2065                2070                2075                2080

Val Asp Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu Ala Asp Ala Leu 
                2085                2090                2095    

Val Leu Ala Glu Ala Asp Ala Leu Val Glu Ala Glu Ala Asp Ala Glu 
            2100                2105                2110        

Val Leu Ala Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu 
        2115                2120                2125            

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp 
    2130                2135                2140                

Ala Leu Val Asp Ala Asp Ser Glu Ala Asp Val Leu Ala Glu Ala Asp 
2145                2150                2155                2160

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Asp Ser Asp 
                2165                2170                2175    

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp 
            2180                2185                2190        

Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Asp Ser Glu 
        2195                2200                2205            

Ala Leu Val Asp Ala Glu Thr Glu Ala Leu Val Asp Ala Glu Ala Asp 
    2210                2215                2220                


Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp 
2225                2230                2235                2240

Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Val Leu Ala Glu Ala Asp 
                2245                2250                2255    

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu 
            2260                2265                2270        

Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp 
        2275                2280                2285            

Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp 
    2290                2295                2300                

Ala Leu Val Asp Ala Asp Ala Asp Ala Leu Val Leu Ala Glu Ala Asp 
2305                2310                2315                2320

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp 
                2325                2330                2335    

Ala Leu Val Asp Ala Asp Ser Asp Ala Leu Val Glu Ala Asp Ala Leu 
            2340                2345                2350        

Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu 
        2355                2360                2365            

Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu 
    2370                2375                2380                

Val Asp Ala Asp Ser Glu Ala Asp Val Leu Ala Glu Ala Asp Val Leu 
2385                2390                2395                2400

Val Asp Ala Asp Ser Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
                2405                2410                2415    

Val Asp Ala Asp Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu 
            2420                2425                2430        

Val Asp Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu Ala Glu Ala Leu 
        2435                2440                2445            

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu 
    2450                2455                2460                

Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Asp Ser Asp Ala Leu 
2465                2470                2475                2480

Val Leu Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Thr Asp Ala Leu 
                2485                2490                2495    

Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Asp Ser Asp Ala Glu 
            2500                2505                2510        

Ile Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
        2515                2520                2525            

Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Glu Ala Leu 
    2530                2535                2540                

Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Asp Ser Asp Ala Leu 
2545                2550                2555                2560


Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu 
                2565                2570                2575    

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Leu 
            2580                2585                2590        

Val Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu 
        2595                2600                2605            

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
    2610                2615                2620                

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp 
2625                2630                2635                2640

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Glu Ala Asp Val Leu 
                2645                2650                2655    

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Leu Val Asp 
            2660                2665                2670        

Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu 
        2675                2680                2685            

Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp 
    2690                2695                2700                

Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
2705                2710                2715                2720

Ala Asp Ser Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp 
                2725                2730                2735    

Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
            2740                2745                2750        

Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu Ala Asp Ala Leu Val Glu 
        2755                2760                2765            

Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Leu 
    2770                2775                2780                

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu 
2785                2790                2795                2800

Ala Asp Ser Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp 
                2805                2810                2815    

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
            2820                2825                2830        

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp 
        2835                2840                2845            

Ala Asp Ser Asp Ala Asp Val Leu Ala Glu Ala Glu Ala Leu Val Asp 
    2850                2855                2860                

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Thr Glu Ala Leu Val Leu 
2865                2870                2875                2880

Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp 
                2885                2890                2895    

Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu 
            2900                2905                2910        

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Leu Val Glu 
        2915                2920                2925            

Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu 
    2930                2935                2940                

Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Asp 
2945                2950                2955                2960

Ser Glu Ala Asp Val Leu Ala Glu Ala Asp Val Leu Val Asp Ala Asp 
                2965                2970                2975    

Ser Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu 
            2980                2985                2990        

Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Glu Ala Glu 
        2995                3000                3005            

Ala Asp Ala Glu Val Leu Ala Leu Ala Glu Ala Asp Ala Leu Val Asp 
    3010                3015                3020                

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp 
3025                3030                3035                3040

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Glu Ala Asp Val Leu 
                3045                3050                3055    

Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp 
            3060                3065                3070        

Ala Asp Ser Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu 
        3075                3080                3085            

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp 
    3090                3095                3100                

Ala Asp Ser Glu Ala Leu Val Asp Ala Glu Thr Glu Ala Leu Val Asp 
3105                3110                3115                3120

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp 
                3125                3130                3135    

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Val Leu 
            3140                3145                3150        

Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu 
        3155                3160                3165            

Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Leu 
    3170                3175                3180                

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Leu 
3185                3190                3195                3200

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ala Asp Ala Leu Val Leu 
                3205                3210                3215    

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Ile Leu 
            3220                3225                3230        

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu 
        3235                3240                3245            

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
    3250                3255                3260                

Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu Ala Glu Ala Leu Val Asp 
3265                3270                3275                3280

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Thr Asp Ala Leu Val Asp 
                3285                3290                3295    

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ala Asp Ala Leu Val Asp 
            3300                3305                3310        

Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu Ala Asp Ala Leu Val Asp 
        3315                3320                3325            

Ala Asp Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
    3330                3335                3340                

Ala Asp Ala Glu Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp 
3345                3350                3355                3360

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Leu 
                3365                3370                3375    

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Glu 
            3380                3385                3390        

Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu 
        3395                3400                3405            

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp 

    3410                3415                3420                

Ala Asp Ser Glu Ala Asp Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
3425                3430                3435                3440

Ala Asp Ser Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu 
                3445                3450                3455    

Ala Glu Ala Glu Ala Leu Val Asp Ala Asp Ser Glu Ala Leu Val Asp 
            3460                3465                3470        

Ala Glu Thr Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu 
        3475                3480                3485            

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp 
    3490                3495                3500                

Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Val Leu 
3505                3510                3515                3520

Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu 
                3525                3530                3535    

Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu 
            3540                3545                3550        

Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
        3555                3560                3565            

Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp 
    3570                3575                3580                

Ala Asp Ser Asp Ala Leu Val Glu Ala Asp Ala Leu Val Asp Ala Glu 
3585                3590                3595                3600

Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Leu Ala Glu 
                3605                3610                3615    

Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Asp 
            3620                3625                3630        

Ser Glu Ala Asp Val Leu Ala Glu Ala Asp Val Leu Val Asp Ala Asp 
        3635                3640                3645            

Ser Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Asp 
    3650                3655                3660                

Ala Glu Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp 
3665                3670                3675                3680

Ser Asp Ala Glu Ile Leu Ala Glu Ala Glu Ala Leu Val Leu Ala Glu 
                3685                3690                3695    

Ala Glu Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Val Leu Ala Glu 
            3700                3705                3710        

Ala Glu Ala Leu Val Asp Ala Asp Ser Asp Ala Leu Val Leu Ala Glu 
        3715                3720                3725            

Ala Asp Ala Leu Val Leu Ala Glu Thr Asp Ala Leu Val Asp Ala Glu 
    3730                3735                3740                

Ala Glu Ala Leu Val Asp Ala Asp Ser Asp Ala Glu Ile Leu Ala Glu 
3745                3750                3755                3760

Ala Glu Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Glu 
                3765                3770                3775    

Ala Glu Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu 
            3780                3785                3790        

Ala Asp Ala Leu Val Leu Ala Asp Ser Asp Ala Leu Val Asp Ala Glu 
        3795                3800                3805            

Ala Asp Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu 
    3810                3815                3820                

Ala Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Leu Val Glu Ala Asp 
3825                3830                3835                3840

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Asp 
                3845                3850                3855    

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp 
            3860                3865                3870        

Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp 
        3875                3880                3885            

Ala Leu Val Asp Ala Asp Ser Glu Ala Asp Val Leu Ala Glu Ala Asp 
    3890                3895                3900                

Ala Leu Val Asp Ala Asp Ser Asp Ala Leu Val Asp Ala Glu Ala Asp 
3905                3910                3915                3920

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Asp 
                3925                3930                3935    

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu 
            3940                3945                3950        

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp 
        3955                3960                3965            

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu 
    3970                3975                3980                

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp 
3985                3990                3995                4000

Ala Glu Ile Leu Ala Glu Ala Asp Ala Leu Val Glu Ala Glu Ala Glu 
                4005                4010                4015    

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Leu Ala Glu Ala Glu 
            4020                4025                4030        

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Leu Ala Asp Ser Asp 
        4035                4040                4045            

Ala Leu Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp 
    4050                4055                4060                

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Asp 
4065                4070                4075                4080

Ala Leu Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Asp Ser Asp 
                4085                4090                4095    

Ala Asp Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Glu 
            4100                4105                4110        

Ala Leu Val Asp Ala Glu Thr Glu Ala Leu Val Leu Ala Glu Ala Asp 
        4115                4120                4125            

Ala Leu Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp 
    4130                4135                4140                

Ala Leu Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Asp Ser Asp 
4145                4150                4155                4160

Ala Leu Val Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
                4165                4170                4175    

Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Asp Ala Leu 
            4180                4185                4190        

Val Glu Ala Asp Ser Glu Ala Glu Val Leu Ala Glu Ala Asp Val Leu 
        4195                4200                4205            

Val Asp Ala Asp Ser Asp Ala Leu Val Asp Ala Asp Ser Asp Ala Glu 
    4210                4215                4220                

Ile Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
4225                4230                4235                4240

Val Asp Ala Glu Ala Asp Val Leu Val Asp Ala Glu Pro Glu Ala Leu 
                4245                4250                4255    

Val Leu Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
            4260                4265                4270        


Val Glu Ala Asp Ser Glu Ala Glu Val Leu Ala Glu Ala Glu Ala Leu 
        4275                4280                4285            

Val Glu Ala Asp Ser Glu Ala Glu Val Leu Ala Glu Ala Glu Ala Leu 
    4290                4295                4300                

Val Asp Ala Glu Ala Glu Ala Leu Val Leu Ala Glu Ala Glu Ala Leu 
4305                4310                4315                4320

Val Asp Ala Asp Ser Asp Ala Asp Val Leu Ala Glu Ala Glu Ala Leu 
                4325                4330                4335    

Val Asp Ala Glu Ala Glu Ala Leu Val Asp Ala Glu Thr Glu Ala Leu 
            4340                4345                4350        

Val Leu Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
        4355                4360                4365            

Val Asp Ala Glu Ala Asp Ala Leu Val Asp Ala Glu Ala Glu Ala Leu 
    4370                4375                4380                


<210>   3659
<211>   13095
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3659
gtgctagtca aagcgcctca gcttcagcat caacaagtgc gtcggcttca gcatcaacca   60
gtgcctcggc ttcagcgtca accagtgcgt cagcttcagc aagtaccagt gcttcagtct   120
cagcatcaac aagtgcttca gcctcagcat cgacaagtgc ctcggcttca gcaagcacat   180
cagcatctga atcagcgtca accagtgctt cggcttcagc aagtaccagt gcttcagctt   240
cagcatcaac cagcgcctcg gcctcagcaa gcacctcagc ttctgaatcg gcctcaacca   300
gcgcctcggc ctcagcaagc acctcagctt ctgaatcggc ctcaaccagc gcctcagcct   360
cagcatcaac gagtgcttcg gcttcagcaa gcacaagcgc ctcgggttca gcatcaacga   420
gtacgtcagc ttcagcgtca accagtgctt cagcctcagc atcaacaagt gcgtcagcct   480
cagcaagtat ctcagcgtct gaatcggcat caacgagtgc gtctgagtca gcatcaacga   540
gtacgtcagc ctcagcaagc acctcagctt ctgaatcggc ctcaaccagt gcgtcagcct   600
cagcatcgac aagcgcctca gcttcagcaa gtaccagtgc ttcagcctca gcgtcgacaa   660
gtgcgtcggc ctcaaccagt gcatctgaat cggcatcaac cagtgcgtca gcctcagcaa   720
gtactagtgc atcggcttca gcatcaacca gtgcctcggc ttcagcgtca accagtgcgt   780
cagcttcagc aagtaccagt gcttcagtct cagcatcaac aagtgcttca gcctcagcat   840
cgacaagtgc ctcggcttca gcaagcacat cagcatctga atcagcgtcg acaagcgcct   900
cagcttcagc aagtaccagt gcgtcagcct cagcgtcgac aagtgcgtca gcctcagcaa   960
gtactagtgc atcagcttca gcatcaacga gtgcatcggc ttcggcgtca accagtgcat   1020
cagagtcagc aagtaccagt gcgtcagctt ccgcatcaac aagtgcctcg gcttcagcaa   1080
gcaccagtgc gtcggcttca gcaagtacta gcgcctcagc ctcagcctca accagtgcgt   1140
cagcctcagc aagtatctca gcgtctgaat cggcatcaac gagtgcgtcc gcttcagcaa   1200
gtactagcgc ctcagcctca gcgtcaacaa gtgcatcggc ttcagcgtca acgagtgcgt   1260
ctgaatcggc atcaacgagt gcgtccgctt cagcaagtac tagcgcctca gcctcagcgt   1320
caacaagtgc atcggcttca gcatcaacga gtgcgtccgc ttcagcaagt actagcgcct   1380
cagcctcagc gtcaacaagt gcatcggctt cagcgtcaac gagtgcgtct gagtcagcat   1440
caacgagtgc gtcagcctca gcaagcacat cagcttctga atctgcatca accagtgcgt   1500
cagcctcagc atcgacaagc gcctcagctt cagcaagtac cagtgcgtca gcctcagcgt   1560
cgacaagtgc gtcggcttca gcaagtacca gtgcgtcagc ctcagcaagt accagtgcgt   1620
cagcctcagc gtcgacaagt gcgtcggcct caaccagtgc atctgaatcg gcatcaacca   1680
gtgcgtcagc ctcagcaagt actagtgcat cagcttcagc atcaacgagt gcatcggctt   1740
cagcatcaac cagtgcatca gagtcagcaa gtaccagtgc gtcagcttcc gcatcaacaa   1800
gtgcctcggc ttcagcaagt actagcgcct cagcctcagc gtcaacaagt gcttcagctt   1860
ccgcgtcaac cagcgcctcg gcctcagcaa gtatctcagc gtctgaatcg gcatcaacaa   1920
gtgcctcggc ttcagcatca acgagtgcat cagtctcagc aagcaccagt gcgtcggcct   1980
cagcaagcac cagcgcgtct gaatccgcat caaccagtgc ctcagcttca gcaagtacct   2040
cagcatctga atcagcatca acaagtgcct cggcttcagc aagcacaagt gcttcagcct   2100
cagcaagtat ctcagcgtct gaatcggcat caacgagtgc gtccgcttca gcaagtacta   2160
gcgcctcagc atcagcgtca acaagtgctt cggcttcagc gtcaacgagt gcgtctgagt   2220
cagcatcaac gagtacgtca gcctcagcaa gcacatcagc ttctgaatct gcatcaacca   2280
gtgcgtcagc ctcagcatcg acaagcgcct cagcttcagc aagtaccagt gcgtcagcct   2340
cagcaagtac cagtgcttca gcctcagcgt cgacaagtgc gtcggcctca accagtgcat   2400
ctgaatcggc atcaaccagt gcgtcagcct cagcaagtac tagcgcctca gcctcagcat   2460
caacgagtgc gtccgcttca gcaagtacta gtgcatcagc ttcagcaagt actagcgcct   2520
cagcctcagc gtcgacaagc gcctcagctt cagcaagtac cagtgcgtca gcctcagcgt   2580
cgacaagtgc gtcggcttca gcaagtacct cagcgtctga atcagcatca acaagtgcgt   2640
cggcttcagc atcaacgagt gcatcagctt cagcatcaac aagtgcttca gcttcagcaa   2700
gtaccagtgc gtcggcttca gcatcaacga gtgcttcagt ctcagcgtca accagtgcct   2760
ctgaatccgc atcaacaagt gcctcggctt cagcaagcac cagtgcttcg gcttcagcgt   2820
caacgagtgc gtctgagtca gcatcaacga gtgcgtcagc ctcagcaagc acatcagctt   2880
ctgaatctgc atcaaccagt gcgtcagctt ccgcatcaac aagcgcctcg gcctcagcaa   2940
gtacaagtgc ttcagcctca gcatcaacca gtgcatcagc ttcagcctca acaagtgctt   3000
cagcctcagc gtcaaccagt gcctcggctt cagcaagtac cagtgcgtca gcttcagcaa   3060
gcacaagtgc gtcagcttca gcatcaacca gtgcttcggc ttcggcatca acaagtgcct   3120
cagcatcagc atcaacgagt gcgtcagcct cagcaagtac tagtgcatca gcatcagcat   3180
caaccagtgc atcagcctca gcaagtatct cagcgtctga atcggcatca acgagtgcat   3240
cagcatcagc atcaacgagt gcatcggctt cagcgtcaac cagtgcatca gtctcagcaa   3300
gcaccagtgc gtcggcttca gcatcaacga gtgcctcagc ctcagcaagt atctcagcgt   3360
ctgaatcggc atcaacgagt gcgtcagcct cagcaagtac tagtgcatcg gcttcagcaa   3420
gcaccagtgc gtcggcttca gcatcaacca gtgcctcagc ctcagcaagt atctcagcgt   3480
ctgaatcggc atcaacgagt gcgtcagcct cagcaagtac tagtgcatca gcatcagcat   3540
caacgagtgc atcggcttca gcaagtacca gcgcctcagc ttcagcaagc accagtgcgt   3600
cagcctcagc aagtaccagc gcctcagcct cagcaagcac cagtgcctca gcttcagcaa   3660
gtaccagtgc gtcagcctca gcgtcgacaa gtgcgtcggc ttcagcaagt acctcagcgt   3720
ctgaatcagc atcaacgagt gcatcagctt cagcatcaac aagtgcttca gcttcagcaa   3780
gtaccagtgc gtcggcttca gcatcaacga gtgcttcagt ctcagcgtca accagtgcct   3840
ctgaatcagc atcaacaagt gcctcggctt cagcaagcac cagtgcgtcg gcttcagcaa   3900
gtactagtgc atcggcttca gcatcgacaa gtgcgtctga atcggcatca acgagtgctt   3960
cggcttcagc atcaacgagt gcgtcagcct cagcaagcac atcagcttct gaatctgcat   4020
caaccagtgc gtccgcttca gcgtcaacca gtgcgtcggc ttcagcgtcg acaagtgctt   4080
cggcttcagc atcaacgagt gcgtcggcct cagcaagcgc aagtacctca gcgtcagctt   4140
ccgcctcaac cagtgcgtcg gcttcagcaa gcacaagtgc gtcagcctca gcaagtatct   4200
cagcgtctga atcggcatca acgagtgcgt ctgagtcagc atcaacgagt acgtcagcct   4260
cagcaagcac atcagcttct gaatctgcat caaccagtgc gtcagcctca gcatcgacaa   4320
gcgcctcagc ttcagcaagt accagtgctt cagcctcagc gtcgacaagt gcgtcggcct   4380
caaccagtgc atctgaatcg gcatcaacca gtgcgtcagc ctcagcaagt actagtgcat   4440
cagcttcagc atcaacgagt gcatcggctt cagcatcaac cagtgcctcg gcttcagcgt   4500
caaccagtgc gtcagcttca gcaagtacca gtgcttcagt ctcagcatca acaagtgctt   4560
cagcctcagc atcgacaagt gcctcggctt cagcaagcac atcagcatct gaatcagcgt   4620
cgacaagcgc ctcagcttca gcaagtacca gtgcgtcagc ctcagcgtcg acaagtgcgt   4680
cagcctcagc aagtactagt gcatcagctt cagcatcaac gagtgcatcg gcttcggcgt   4740
caaccagtgc atcagagtca gcaagtacca gtgcgtcagc ttccgcatca acaagtgcct   4800
cggcttcagc aagcaccagt gcgtcggctt cagcaagtac tagcgcctca gcctcagcct   4860
caaccagtgc gtcagcctca gcaagtatct cagcgtctga atcggcatca acgagtgcgt   4920
ccgcttcagc aagtactagc gcctcagcct cagcgtcaac aagtgcatcg gcttcagcgt   4980
caacgagtgc gtctgaatcg gcatcaacga gtgcgtccgc ttcagcaagt actagcgcct   5040
cagcctcagc gtcaacaagt gcatcggctt cagcatcaac gagtgcgtcc gcttcagcaa   5100
gtactagcgc ctcagcctca gcgtcaacaa gtgcatcggc ttcagcgtca acgagtgcgt   5160
ctgagtcagc atcaacgagt gcgtcagcct cagcaagcac atcagcttct gaatctgcat   5220
caaccagtgc gtcagcctca gcatcgacaa gcgcctcagc ttcagcaagt accagtgcgt   5280
cagcctcagc gtcgacaagt gcgtcggctt cagcaagtac cagtgcgtca gcctcagcaa   5340
gtaccagtgc gtcagcctca gcgtcgacaa gtgcgtcggc ctcaaccagt gcatctgaat   5400
cggcatcaac cagtgcgtca gcctcagcaa gtactagtgc atcagcttca gcatcaacga   5460
gtgcatcggc ttcagcatca accagtgcat cagagtcagc aagtaccagt gcgtcagctt   5520
ccgcatcaac aagtgcctcg gcttcagcaa gtactagcgc ctcagcctca gcgtcaacaa   5580
gtgcttcagc ttccgcgtca accagcgcct cggcctcagc aagtatctca gcgtctgaat   5640
cggcatcaac aagtgcctcg gcttcagcat caacgagtgc atcagtctca gcaagcacca   5700
gtgcgtcggc ctcagcaagc accagcgcgt ctgaatccgc atcaaccagt gcctcagctt   5760
cagcaagtac ctcagcatct gaatcagcat caacaagtgc atcggcttca gcaagcacaa   5820
gtgcttcagc ctcagcaagt atctcagcgt ctgaatcggc atcaacgagt gcgtccgctt   5880
cagcaagtac tagcgcctca gcatcagcgt caacaagtgc ttcggcttca gcgtcaacga   5940
gtgcgtctga gtcagcatca acgagtacgt cagcctcagc aagcacatca gcttctgaat   6000
ctgcatcaac cagtgcgtca gcctcagcat cgacaagcgc ctcagcttca gcaagtacca   6060
gtgcgtcagc ctcagcaagt accagtgctt cagcctcagc gtcgacaagt gcgtcggcct   6120
caaccagtgc atctgaatcg gcatcaacca gtgcgtcagc ctcagcaagt actagcgcct   6180
cagcctcagc atcaacgagt gcgtccgctt cagcaagtac tagtgcatca gcatcagcat   6240
caacgagtgc atcggcttca gcaagtacca gcgcctcagc ttcagcaagc accagtgcgt   6300
cagcctcagc aagtaccagc gcctcagcct cagcaagcac cagtgcctca gcttcagcaa   6360
gtaccagtgc gtcagcctca gcgtcgacaa gtgcgtcggc ttcagcaagt acctcagcgt   6420
ctgaatcagc atcaacgagt gcatcagctt cagcatcaac aagtgcttca gcttcagcaa   6480
gtaccagtgc gtcggcttca gcatcaacga gtgcttcagt ctcagcgtca accagtgcct   6540
ctgaatcagc atcaacaagt gcctcggctt cagcaagcac cagtgcgtcg gcttcagcaa   6600
gtactagtgc atcggcttca gcatcgacaa gtgcgtctga atcggcatca acgagtgctt   6660
cggcttcagc atcaacgagt gcgtcagcct cagcaagcac atcagcttct gaatctgcat   6720
caaccagtgc gtccgcttca gcgtcaacca gtgcgtcggc ttcagcgtcg acaagtgctt   6780
cggcttcagc atcaacgagt gcgtcggcct cagcaagcgc aagtacctca gcgtcagctt   6840
ccgcctcaac cagtgcgtcc gcttcagcaa gcacaagtgc gtcagcctca gcaagtatct   6900
cagcgtctga atcggcatca acgagtgcgt cggcctcagc aagcgcaagt acctcagcgt   6960
cagcttccgc ctcaaccagt gcgtcggctt cagcaagcac aagtgcgtca gcctcagcaa   7020
gtatctcagc gtctgaatcg gcatcaacga gtgcgtctga gtcagcatca acgagtacgt   7080
cagcctcagc aagcacatca gcttctgaat cggcatcaac cagtgcgtca gcctcagcat   7140
cgacaagcgc ctcagcttca gcaagtacca gtgcttcagc ctcagcgtcg acaagtgcgt   7200
cggcctcaac cagtgcatct gaatcggcat caaccagtgc gtcagcctca gcaagtacta   7260
gtgcatcagc ttcagcatca acgagtgcat cggcttcagc atcaaccagt gcctcggctt   7320
cagcgtcaac cagtgcgtca gcttcagcaa gtaccagtgc ttcagtctca gcatcaacaa   7380
gtgcttcagc ctcagcatcg acaagtgcct cggcttcagc aagcacatca gcatctgaat   7440
cagcgtcgac aagtgcgtcg gcctcaacca gtgcatctga atcggcatca accagtgcgt   7500
cagcctcagc aagtactagt gcatcagctt cagcatcaac gagtgcatcg gcttcggcgt   7560
caaccagtgc atcagagtca gcaagtacca gtgcgtcagc ttccgcatca acaagtgcct   7620
cggcttcagc aagcacatca gcatctgaat cagcgtcaac cagtgcttcg gcttcagcaa   7680
gtaccagtgc ttcagcttca gcatcaacca gcgcctcggc ctcagcaagc acctcagctt   7740
ctgaatcggc ctcaaccagc gcctcggcct cagcaagcac ctcagcttct gaatcggcct   7800
caaccagcgc ctcagcctca gcatcaacga gtgcttcggc ttcagcaagc acaagcgcct   7860
cgggttcagc atcaacgagt acgtcagctt cagcgtcaac cagtgcttca gcctcagcat   7920
caacaagtgc gtcagcctca gcaagtatct cagcgtctga atcggcatca acgagtgcgt   7980
ctgagtcagc atcaacgagt acgtcagcct cagcaagcac ctcagcttct gaatcggcct   8040
caaccagtgc gtcagcctca gcatcgacaa gcgcctcagc ttcagcaagt accagtgctt   8100
cagcctcagc gtcgacaagt gcgtcggcct caaccagtgc atctgaatcg gcatcaacca   8160
gtgcgtcagc ctcagcaagt actagtgcat cggcttcagc atcaaccagt gcctcggctt   8220
cagcgtcaac cagtgcgtca gcttcagcaa gtaccagtgc ttcagtctca gcatcaacaa   8280
gtgcttcagc ctcagcatcg acaagtgcct cggcttcagc aagcacatca gcatctgaat   8340
cagcgtcgac aagcgcctca gcttcagcaa gtaccagtgc gtcagcctca gcgtcgacaa   8400
gtgcgtcagc ctcagcaagt actagtgcat cagcttcagc atcaacgagt gcatcggctt   8460
cggcgtcaac cagtgcatca gagtcagcaa gtaccagtgc gtcagcttcc gcatcaacaa   8520
gtgcctcggc ttcagcaagc accagtgcgt cggcttcagc aagtactagc gcctcagcct   8580
cagcctcaac cagtgcgtca gcctcagcaa gtatctcagc gtctgaatcg gcatcaacga   8640
gtgcgtccgc ttcagcaagt actagcgcct cagcctcagc gtcaacaagt gcatcggctt   8700
cagcgtcaac gagtgcgtct gaatcggcat caacgagtgc gtccgcttca gcaagtacta   8760
gcgcctcagc ctcagcgtca acaagtgcat cggcttcagc atcaacgagt gcgtccgctt   8820
cagcaagtac tagcgcctca gcctcagcgt caacaagtgc atcggcttca gcgtcaacga   8880
gtgcgtctga gtcagcatca acgagtgcgt cagcctcagc aagcacatca gcttctgaat   8940
ctgcatcaac cagtgcgtca gcctcagcat cgacaagcgc ctcagcttca gcaagtacca   9000
gtgcgtcagc ctcagcgtcg acaagtgcgt cggcttcagc aagtaccagt gcgtcagcct   9060
cagcaagtac cagtgcgtca gcctcagcgt cgacaagtgc gtcggcctca accagtgcat   9120
ctgaatcggc atcaaccagt gcgtcagcct cagcaagtac tagtgcatca gcttcagcat   9180
caacgagtgc atcggcttca gcatcaacca gtgcatcaga gtcagcaagt accagtgcgt   9240
cagcttccgc atcaacaagt gcctcggctt cagcaagtac tagcgcctca gcctcagcgt   9300
caacaagtgc ttcagcttcc gcgtcaacca gcgcctcggc ctcagcaagt atctcagcgt   9360
ctgaatcggc atcaacaagt gcctcggctt cagcatcaac gagtgcatca gtctcagcaa   9420
gcaccagtgc gtcggcctca gcaagcacca gcgcgtctga atccgcatca accagtgcct   9480
cagcttcagc aagtacctca gcatctgaat cagcatcaac aagtgcctcg gcttcagcaa   9540
gcacaagtgc ttcagcctca gcaagtatct cagcgtctga atcggcatca acgagtgcgt   9600
ccgcttcagc aagtactagc gcctcagcat cagcgtcaac aagtgcttcg gcttcagcgt   9660
caacgagtgc gtctgagtca gcatcaacga gtacgtcagc ctcagcaagc acatcagctt   9720
ctgaatctgc atcaaccagt gcgtcagcct cagcatcgac aagcgcctca gcttcagcaa   9780
gtaccagtgc gtcagcctca gcaagtacca gtgcttcagc ctcagcgtcg acaagtgcgt   9840
cggcctcaac cagtgcatct gaatcggcat caaccagtgc gtcagcctca gcaagtacta   9900
gcgcctcagc ctcagcatca acgagtgcgt ccgcttcagc aagtactagt gcatcagctt   9960
cagcaagtac tagcgcctca gcctcagcgt cgacaagcgc ctcagcttca gcaagtacca   10020
gtgcgtcagc ctcagcgtcg acaagtgcgt cggcttcagc aagtacctca gcgtctgaat   10080
cagcatcaac aagtgcgtcg gcttcagcat caacgagtgc atcagcttca gcatcaacaa   10140
gtgcttcagc ttcagcaagt accagtgcgt cggcttcagc atcaacgagt gcttcagtct   10200
cagcgtcaac cagtgcctct gaatccgcat caacaagtgc ctcggcttca gcaagcacca   10260
gtgcttcggc ttcagcgtca acgagtgcgt ctgagtcagc atcaacgagt gcgtcagcct   10320
cagcaagcac atcagcttct gaatctgcat caaccagtgc gtcagcttcc gcatcaacaa   10380
gcgcctcggc ctcagcaagt acaagtgctt cagcctcagc atcaaccagt gcatcagctt   10440
cagcctcaac aagtgcttca gcctcagcgt caaccagtgc ctcggcttca gcaagtacca   10500
gtgcgtcagc ttcagcaagc acaagtgcgt cagcttcagc atcaaccagt gcttcggctt   10560
cggcatcaac aagtgcctca gcatcagcat caacgagtgc gtcagcctca gcaagtacta   10620
gtgcatcagc atcagcatca accagtgcat cagcctcagc aagtatctca gcgtctgaat   10680
cggcatcaac gagtgcatca gcatcagcat caacgagtgc atcggcttca gcgtcaacca   10740
gtgcatcagt ctcagcaagc accagtgcgt cggcttcagc atcaacgagt gcctcagcct   10800
cagcaagtat ctcagcgtct gaatcggcat caacgagtgc gtcagcctca gcaagtacta   10860
gtgcatcggc ttcagcaagc accagtgcgt cggcttcagc atcaaccagt gcctcagcct   10920
cagcaagtat ctcagcgtct gaatcggcat caacgagtgc gtcagcctca gcaagtacta   10980
gtgcatcagc atcagcatca acgagtgcat cggcttcagc aagtaccagc gcctcagctt   11040
cagcaagcac cagtgcgtca gcctcagcaa gtaccagcgc ctcagcctca gcaagcacca   11100
gtgcctcagc ttcagcaagt accagtgcgt cagcctcagc gtcgacaagt gcgtcggctt   11160
cagcaagtac ctcagcgtct gaatcagcat caacgagtgc atcagcttca gcatcaacaa   11220
gtgcttcagc ttcagcaagt atctcagcgt ctgaatcggc atcaacgagt gcgtccgctt   11280
cagcaagtac tagcgcctca gcatcagcgt caacaagtgc ttcggcttca gcgtcaacga   11340
gtgcgtctga gtcagcatca acgagtacgt cagcctcagc aagcacatca gcttctgaat   11400
ctgcatcaac cagtgcgtca gcctcagcat cgacaagcgc ctcagcttca gcaagtacca   11460
gtgcgtcagc ctcagcaagt accagtgctt cagcctcagc gtcgacaagt gcgtcggcct   11520
caaccagtgc atctgaatcg gcatcaacca gtgcgtcagc ctcagcaagt actagcgcct   11580
cagcctcagc atcaacgagt gcgtccgctt cagcaagtac tagtgcatca gcttcagcaa   11640
gtactagcgc ctcagcctca gcgtcgacaa gcgcctcagc ttcagcaagt accagtgcgt   11700
cagcctcagc gtcgacaagt gcgtcggctt cagcaagtac ctcagcgtct gaatcagcat   11760
caacaagtgc gtcggcttca gcatcaacga gtgcatcagc ttcagcatca acaagtgctt   11820
cagcttcagc aagtaccagt gcgtcggctt cagcatcaac gagtgcttca gtctcagcgt   11880
caaccagtgc ctctgaatcc gcatcaacaa gtgcctcggc ttcagcaagc accagtgctt   11940
cggcttcagc gtcaacgagt gcgtctgagt cagcatcaac gagtgcgtca gcctcagcaa   12000
gcacatcagc ttctgaatct gcatcaacca gtgcgtcagc ttccgcatca acaagcgcct   12060
cggcctcagc aagtacaagt gcttcagcct cagcatcaac cagtgcatca gcttcagcct   12120
caacaagtgc ttcagcctca gcgtcaacca gtgcctcggc ttcagcaagt accagtgcgt   12180
cagcttcagc aagcacaagt gcgtcagctt cagcatcaac cagtgcttcg gcttcggcat   12240
caacaagtgc ctcagcatca gcatcaacga gtgcgtcagc ctcagcaagt actagtgcat   12300
cagcatcagc atcaaccagt gcatcagcct cagcaagtat ctcagcgtct gaatcggcat   12360
caacgagtgc atcagcatca gcatcaacga gtgcatcggc ttcagcgtca accagtgcat   12420
cagtctcagc aagcaccagt gcgtcggctt cagcatcaac gagtgcctca gcctcagcaa   12480
gtatctcagc gtctgaatcg gcatcaacga gtgcgtcagc ctcagcaagt actagtgcat   12540
cggcttcagc aagcaccagt gcgtcggctt cagcatcaac cagtgcctca gcctcagcaa   12600
gtatctcagc gtctgaatcg gcatcaacga gtgcgtcagc ctcagcaagt actagtgcat   12660
cagcctcagc atcaacgagt gcatcggctt cagcaagtac cagcgcctca gcttcagcaa   12720
gcaccagtgc gtcagcctca gcaagtacca gcgcctcagc ctcagcaagc accagtgcct   12780
cagcttcagc aagtaccagt gcgtcagcct cagcatcaac aagtgcttca gcttcggcct   12840
caacaagtgc gtcagcttca gcatcaacga gtgcgtcggc ttcagcaagc accagtgcct   12900
cggcctcagc aagcaccagt gcttcagctt cagcatcaac aagtgcgtca gcttcagcaa   12960
gtacatcagt ttcaaattca gcaaaccatt cgaactcaca agttggaaat acttctggat   13020
cgacaggtaa atcccaaaaa gaattgccta atacaggtac tgagtcgtca attggatctg   13080
tgttacttgg agttc                                                    13095

<210>   3660
<211>   4365
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3660

Met Leu Val Lys Ala Pro Gln Leu Gln His Gln Gln Val Arg Arg Leu 
1               5                   10                  15      

Gln His Gln Pro Val Pro Arg Leu Gln Arg Gln Pro Val Arg Gln Leu 
            20                  25                  30          

Gln Gln Val Pro Val Leu Gln Ser Gln His Gln Gln Val Leu Gln Pro 
        35                  40                  45              

Gln His Arg Gln Val Pro Arg Leu Gln Gln Ala His Gln His Leu Asn 
    50                  55                  60                  

Gln Arg Gln Pro Val Leu Arg Leu Gln Gln Val Pro Val Leu Gln Leu 
65                  70                  75                  80  

Gln His Gln Pro Ala Pro Arg Pro Gln Gln Ala Pro Gln Leu Leu Asn 
                85                  90                  95      

Arg Pro Gln Pro Ala Pro Arg Pro Gln Gln Ala Pro Gln Leu Leu Asn 
            100                 105                 110         

Arg Pro Gln Pro Ala Pro Gln Pro Gln His Gln Arg Val Leu Arg Leu 
        115                 120                 125             

Gln Gln Ala Gln Ala Pro Arg Val Gln His Gln Arg Val Arg Gln Leu 
    130                 135                 140                 

Gln Arg Gln Pro Val Leu Gln Pro Gln His Gln Gln Val Arg Gln Pro 
145                 150                 155                 160 

Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Arg Val Arg Leu Ser 
                165                 170                 175     

Gln His Gln Arg Val Arg Gln Pro Gln Gln Ala Pro Gln Leu Leu Asn 
            180                 185                 190         

Arg Pro Gln Pro Val Arg Gln Pro Gln His Arg Gln Ala Pro Gln Leu 
        195                 200                 205             

Gln Gln Val Pro Val Leu Gln Pro Gln Arg Arg Gln Val Arg Arg Pro 
    210                 215                 220                 

Gln Pro Val His Leu Asn Arg His Gln Pro Val Arg Gln Pro Gln Gln 
225                 230                 235                 240 

Val Leu Val His Arg Leu Gln His Gln Pro Val Pro Arg Leu Gln Arg 
                245                 250                 255     

Gln Pro Val Arg Gln Leu Gln Gln Val Pro Val Leu Gln Ser Gln His 
            260                 265                 270         

Gln Gln Val Leu Gln Pro Gln His Arg Gln Val Pro Arg Leu Gln Gln 
        275                 280                 285             

Ala His Gln His Leu Asn Gln Arg Arg Gln Ala Pro Gln Leu Gln Gln 
    290                 295                 300                 

Val Pro Val Arg Gln Pro Gln Arg Arg Gln Val Arg Gln Pro Gln Gln 
305                 310                 315                 320 

Val Leu Val His Gln Leu Gln His Gln Arg Val His Arg Leu Arg Arg 
                325                 330                 335     

Gln Pro Val His Gln Ser Gln Gln Val Pro Val Arg Gln Leu Pro His 
            340                 345                 350         

Gln Gln Val Pro Arg Leu Gln Gln Ala Pro Val Arg Arg Leu Gln Gln 
        355                 360                 365             

Val Leu Ala Pro Gln Pro Gln Pro Gln Pro Val Arg Gln Pro Gln Gln 
    370                 375                 380                 

Val Ser Gln Arg Leu Asn Arg His Gln Arg Val Arg Pro Leu Gln Gln 
385                 390                 395                 400 

Val Leu Ala Pro Gln Pro Gln Arg Gln Gln Val His Arg Leu Gln Arg 
                405                 410                 415     

Gln Arg Val Arg Leu Asn Arg His Gln Arg Val Arg Pro Leu Gln Gln 
            420                 425                 430         

Val Leu Ala Pro Gln Pro Gln Arg Gln Gln Val His Arg Leu Gln His 
        435                 440                 445             

Gln Arg Val Arg Pro Leu Gln Gln Val Leu Ala Pro Gln Pro Gln Arg 
    450                 455                 460                 

Gln Gln Val His Arg Leu Gln Arg Gln Arg Val Arg Leu Ser Gln His 
465                 470                 475                 480 

Gln Arg Val Arg Gln Pro Gln Gln Ala His Gln Leu Leu Asn Leu His 
                485                 490                 495     

Gln Pro Val Arg Gln Pro Gln His Arg Gln Ala Pro Gln Leu Gln Gln 
            500                 505                 510         

Val Pro Val Arg Gln Pro Gln Arg Arg Gln Val Arg Arg Leu Gln Gln 
        515                 520                 525             

Val Pro Val Arg Gln Pro Gln Gln Val Pro Val Arg Gln Pro Gln Arg 
    530                 535                 540                 

Arg Gln Val Arg Arg Pro Gln Pro Val His Leu Asn Arg His Gln Pro 
545                 550                 555                 560 

Val Arg Gln Pro Gln Gln Val Leu Val His Gln Leu Gln His Gln Arg 
                565                 570                 575     

Val His Arg Leu Gln His Gln Pro Val His Gln Ser Gln Gln Val Pro 
            580                 585                 590         

Val Arg Gln Leu Pro His Gln Gln Val Pro Arg Leu Gln Gln Val Leu 
        595                 600                 605             

Ala Pro Gln Pro Gln Arg Gln Gln Val Leu Gln Leu Pro Arg Gln Pro 
    610                 615                 620                 

Ala Pro Arg Pro Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Gln 
625                 630                 635                 640 

Val Pro Arg Leu Gln His Gln Arg Val His Gln Ser Gln Gln Ala Pro 
                645                 650                 655     

Val Arg Arg Pro Gln Gln Ala Pro Ala Arg Leu Asn Pro His Gln Pro 
            660                 665                 670         

Val Pro Gln Leu Gln Gln Val Pro Gln His Leu Asn Gln His Gln Gln 
        675                 680                 685             

Val Pro Arg Leu Gln Gln Ala Gln Val Leu Gln Pro Gln Gln Val Ser 
    690                 695                 700                 

Gln Arg Leu Asn Arg His Gln Arg Val Arg Pro Leu Gln Gln Val Leu 
705                 710                 715                 720 

Ala Pro Gln His Gln Arg Gln Gln Val Leu Arg Leu Gln Arg Gln Arg 
                725                 730                 735     

Val Arg Leu Ser Gln His Gln Arg Val Arg Gln Pro Gln Gln Ala His 
            740                 745                 750         

Gln Leu Leu Asn Leu His Gln Pro Val Arg Gln Pro Gln His Arg Gln 
        755                 760                 765             

Ala Pro Gln Leu Gln Gln Val Pro Val Arg Gln Pro Gln Gln Val Pro 
    770                 775                 780                 

Val Leu Gln Pro Gln Arg Arg Gln Val Arg Arg Pro Gln Pro Val His 
785                 790                 795                 800 

Leu Asn Arg His Gln Pro Val Arg Gln Pro Gln Gln Val Leu Ala Pro 
                805                 810                 815     

Gln Pro Gln His Gln Arg Val Arg Pro Leu Gln Gln Val Leu Val His 
            820                 825                 830         

Gln Leu Gln Gln Val Leu Ala Pro Gln Pro Gln Arg Arg Gln Ala Pro 
        835                 840                 845             

Gln Leu Gln Gln Val Pro Val Arg Gln Pro Gln Arg Arg Gln Val Arg 

    850                 855                 860                 

Arg Leu Gln Gln Val Pro Gln Arg Leu Asn Gln His Gln Gln Val Arg 
865                 870                 875                 880 

Arg Leu Gln His Gln Arg Val His Gln Leu Gln His Gln Gln Val Leu 
                885                 890                 895     

Gln Leu Gln Gln Val Pro Val Arg Arg Leu Gln His Gln Arg Val Leu 
            900                 905                 910         

Gln Ser Gln Arg Gln Pro Val Pro Leu Asn Pro His Gln Gln Val Pro 
        915                 920                 925             

Arg Leu Gln Gln Ala Pro Val Leu Arg Leu Gln Arg Gln Arg Val Arg 
    930                 935                 940                 

Leu Ser Gln His Gln Arg Val Arg Gln Pro Gln Gln Ala His Gln Leu 
945                 950                 955                 960 

Leu Asn Leu His Gln Pro Val Arg Gln Leu Pro His Gln Gln Ala Pro 
                965                 970                 975     

Arg Pro Gln Gln Val Gln Val Leu Gln Pro Gln His Gln Pro Val His 
            980                 985                 990         

Gln Leu Gln Pro Gln Gln Val Leu Gln Pro Gln Arg Gln Pro Val Pro 
        995                 1000                1005            

Arg Leu Gln Gln Val Pro Val Arg Gln Leu Gln Gln Ala Gln Val Arg 
    1010                1015                1020                

Gln Leu Gln His Gln Pro Val Leu Arg Leu Arg His Gln Gln Val Pro 
1025                1030                1035                1040

Gln His Gln His Gln Arg Val Arg Gln Pro Gln Gln Val Leu Val His 
                1045                1050                1055    

Gln His Gln His Gln Pro Val His Gln Pro Gln Gln Val Ser Gln Arg 
            1060                1065                1070        

Leu Asn Arg His Gln Arg Val His Gln His Gln His Gln Arg Val His 
        1075                1080                1085            

Arg Leu Gln Arg Gln Pro Val His Gln Ser Gln Gln Ala Pro Val Arg 
    1090                1095                1100                

Arg Leu Gln His Gln Arg Val Pro Gln Pro Gln Gln Val Ser Gln Arg 
1105                1110                1115                1120

Leu Asn Arg His Gln Arg Val Arg Gln Pro Gln Gln Val Leu Val His 
                1125                1130                1135    

Arg Leu Gln Gln Ala Pro Val Arg Arg Leu Gln His Gln Pro Val Pro 
            1140                1145                1150        

Gln Pro Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Arg Val Arg 
        1155                1160                1165            

Gln Pro Gln Gln Val Leu Val His Gln His Gln His Gln Arg Val His 
    1170                1175                1180                

Arg Leu Gln Gln Val Pro Ala Pro Gln Leu Gln Gln Ala Pro Val Arg 
1185                1190                1195                1200

Gln Pro Gln Gln Val Pro Ala Pro Gln Pro Gln Gln Ala Pro Val Pro 
                1205                1210                1215    

Gln Leu Gln Gln Val Pro Val Arg Gln Pro Gln Arg Arg Gln Val Arg 
            1220                1225                1230        

Arg Leu Gln Gln Val Pro Gln Arg Leu Asn Gln His Gln Arg Val His 
        1235                1240                1245            

Gln Leu Gln His Gln Gln Val Leu Gln Leu Gln Gln Val Pro Val Arg 
    1250                1255                1260                

Arg Leu Gln His Gln Arg Val Leu Gln Ser Gln Arg Gln Pro Val Pro 
1265                1270                1275                1280

Leu Asn Gln His Gln Gln Val Pro Arg Leu Gln Gln Ala Pro Val Arg 
                1285                1290                1295    

Arg Leu Gln Gln Val Leu Val His Arg Leu Gln His Arg Gln Val Arg 
            1300                1305                1310        

Leu Asn Arg His Gln Arg Val Leu Arg Leu Gln His Gln Arg Val Arg 
        1315                1320                1325            

Gln Pro Gln Gln Ala His Gln Leu Leu Asn Leu His Gln Pro Val Arg 
    1330                1335                1340                

Pro Leu Gln Arg Gln Pro Val Arg Arg Leu Gln Arg Arg Gln Val Leu 
1345                1350                1355                1360

Arg Leu Gln His Gln Arg Val Arg Arg Pro Gln Gln Ala Gln Val Pro 
                1365                1370                1375    

Gln Arg Gln Leu Pro Pro Gln Pro Val Arg Arg Leu Gln Gln Ala Gln 
            1380                1385                1390        

Val Arg Gln Pro Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Arg 
        1395                1400                1405            

Val Arg Leu Ser Gln His Gln Arg Val Arg Gln Pro Gln Gln Ala His 
    1410                1415                1420                

Gln Leu Leu Asn Leu His Gln Pro Val Arg Gln Pro Gln His Arg Gln 
1425                1430                1435                1440

Ala Pro Gln Leu Gln Gln Val Pro Val Leu Gln Pro Gln Arg Arg Gln 
                1445                1450                1455    

Val Arg Arg Pro Gln Pro Val His Leu Asn Arg His Gln Pro Val Arg 
            1460                1465                1470        

Gln Pro Gln Gln Val Leu Val His Gln Leu Gln His Gln Arg Val His 
        1475                1480                1485            

Arg Leu Gln His Gln Pro Val Pro Arg Leu Gln Arg Gln Pro Val Arg 
    1490                1495                1500                

Gln Leu Gln Gln Val Pro Val Leu Gln Ser Gln His Gln Gln Val Leu 
1505                1510                1515                1520

Gln Pro Gln His Arg Gln Val Pro Arg Leu Gln Gln Ala His Gln His 
                1525                1530                1535    

Leu Asn Gln Arg Arg Gln Ala Pro Gln Leu Gln Gln Val Pro Val Arg 
            1540                1545                1550        

Gln Pro Gln Arg Arg Gln Val Arg Gln Pro Gln Gln Val Leu Val His 
        1555                1560                1565            

Gln Leu Gln His Gln Arg Val His Arg Leu Arg Arg Gln Pro Val His 
    1570                1575                1580                

Gln Ser Gln Gln Val Pro Val Arg Gln Leu Pro His Gln Gln Val Pro 
1585                1590                1595                1600

Arg Leu Gln Gln Ala Pro Val Arg Arg Leu Gln Gln Val Leu Ala Pro 
                1605                1610                1615    

Gln Pro Gln Pro Gln Pro Val Arg Gln Pro Gln Gln Val Ser Gln Arg 
            1620                1625                1630        

Leu Asn Arg His Gln Arg Val Arg Pro Leu Gln Gln Val Leu Ala Pro 
        1635                1640                1645            

Gln Pro Gln Arg Gln Gln Val His Arg Leu Gln Arg Gln Arg Val Arg 
    1650                1655                1660                

Leu Asn Arg His Gln Arg Val Arg Pro Leu Gln Gln Val Leu Ala Pro 
1665                1670                1675                1680

Gln Pro Gln Arg Gln Gln Val His Arg Leu Gln His Gln Arg Val Arg 
                1685                1690                1695    

Pro Leu Gln Gln Val Leu Ala Pro Gln Pro Gln Arg Gln Gln Val His 
            1700                1705                1710        


Arg Leu Gln Arg Gln Arg Val Arg Leu Ser Gln His Gln Arg Val Arg 
        1715                1720                1725            

Gln Pro Gln Gln Ala His Gln Leu Leu Asn Leu His Gln Pro Val Arg 
    1730                1735                1740                

Gln Pro Gln His Arg Gln Ala Pro Gln Leu Gln Gln Val Pro Val Arg 
1745                1750                1755                1760

Gln Pro Gln Arg Arg Gln Val Arg Arg Leu Gln Gln Val Pro Val Arg 
                1765                1770                1775    

Gln Pro Gln Gln Val Pro Val Arg Gln Pro Gln Arg Arg Gln Val Arg 
            1780                1785                1790        

Arg Pro Gln Pro Val His Leu Asn Arg His Gln Pro Val Arg Gln Pro 
        1795                1800                1805            

Gln Gln Val Leu Val His Gln Leu Gln His Gln Arg Val His Arg Leu 
    1810                1815                1820                

Gln His Gln Pro Val His Gln Ser Gln Gln Val Pro Val Arg Gln Leu 
1825                1830                1835                1840

Pro His Gln Gln Val Pro Arg Leu Gln Gln Val Leu Ala Pro Gln Pro 
                1845                1850                1855    

Gln Arg Gln Gln Val Leu Gln Leu Pro Arg Gln Pro Ala Pro Arg Pro 
            1860                1865                1870        

Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Gln Val Pro Arg Leu 
        1875                1880                1885            

Gln His Gln Arg Val His Gln Ser Gln Gln Ala Pro Val Arg Arg Pro 
    1890                1895                1900                

Gln Gln Ala Pro Ala Arg Leu Asn Pro His Gln Pro Val Pro Gln Leu 
1905                1910                1915                1920

Gln Gln Val Pro Gln His Leu Asn Gln His Gln Gln Val His Arg Leu 
                1925                1930                1935    

Gln Gln Ala Gln Val Leu Gln Pro Gln Gln Val Ser Gln Arg Leu Asn 
            1940                1945                1950        

Arg His Gln Arg Val Arg Pro Leu Gln Gln Val Leu Ala Pro Gln His 
        1955                1960                1965            

Gln Arg Gln Gln Val Leu Arg Leu Gln Arg Gln Arg Val Arg Leu Ser 
    1970                1975                1980                

Gln His Gln Arg Val Arg Gln Pro Gln Gln Ala His Gln Leu Leu Asn 
1985                1990                1995                2000

Leu His Gln Pro Val Arg Gln Pro Gln His Arg Gln Ala Pro Gln Leu 
                2005                2010                2015    

Gln Gln Val Pro Val Arg Gln Pro Gln Gln Val Pro Val Leu Gln Pro 
            2020                2025                2030        

Gln Arg Arg Gln Val Arg Arg Pro Gln Pro Val His Leu Asn Arg His 
        2035                2040                2045            


Gln Pro Val Arg Gln Pro Gln Gln Val Leu Ala Pro Gln Pro Gln His 
    2050                2055                2060                

Gln Arg Val Arg Pro Leu Gln Gln Val Leu Val His Gln His Gln His 
2065                2070                2075                2080

Gln Arg Val His Arg Leu Gln Gln Val Pro Ala Pro Gln Leu Gln Gln 
                2085                2090                2095    

Ala Pro Val Arg Gln Pro Gln Gln Val Pro Ala Pro Gln Pro Gln Gln 
            2100                2105                2110        

Ala Pro Val Pro Gln Leu Gln Gln Val Pro Val Arg Gln Pro Gln Arg 
        2115                2120                2125            

Arg Gln Val Arg Arg Leu Gln Gln Val Pro Gln Arg Leu Asn Gln His 
    2130                2135                2140                

Gln Arg Val His Gln Leu Gln His Gln Gln Val Leu Gln Leu Gln Gln 
2145                2150                2155                2160

Val Pro Val Arg Arg Leu Gln His Gln Arg Val Leu Gln Ser Gln Arg 
                2165                2170                2175    

Gln Pro Val Pro Leu Asn Gln His Gln Gln Val Pro Arg Leu Gln Gln 
            2180                2185                2190        

Ala Pro Val Arg Arg Leu Gln Gln Val Leu Val His Arg Leu Gln His 
        2195                2200                2205            

Arg Gln Val Arg Leu Asn Arg His Gln Arg Val Leu Arg Leu Gln His 
    2210                2215                2220                

Gln Arg Val Arg Gln Pro Gln Gln Ala His Gln Leu Leu Asn Leu His 
2225                2230                2235                2240

Gln Pro Val Arg Pro Leu Gln Arg Gln Pro Val Arg Arg Leu Gln Arg 
                2245                2250                2255    

Arg Gln Val Leu Arg Leu Gln His Gln Arg Val Arg Arg Pro Gln Gln 
            2260                2265                2270        

Ala Gln Val Pro Gln Arg Gln Leu Pro Pro Gln Pro Val Arg Pro Leu 
        2275                2280                2285            

Gln Gln Ala Gln Val Arg Gln Pro Gln Gln Val Ser Gln Arg Leu Asn 
    2290                2295                2300                

Arg His Gln Arg Val Arg Arg Pro Gln Gln Ala Gln Val Pro Gln Arg 
2305                2310                2315                2320

Gln Leu Pro Pro Gln Pro Val Arg Arg Leu Gln Gln Ala Gln Val Arg 
                2325                2330                2335    

Gln Pro Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Arg Val Arg 
            2340                2345                2350        

Leu Ser Gln His Gln Arg Val Arg Gln Pro Gln Gln Ala His Gln Leu 
        2355                2360                2365            

Leu Asn Arg His Gln Pro Val Arg Gln Pro Gln His Arg Gln Ala Pro 
    2370                2375                2380                

Gln Leu Gln Gln Val Pro Val Leu Gln Pro Gln Arg Arg Gln Val Arg 
2385                2390                2395                2400

Arg Pro Gln Pro Val His Leu Asn Arg His Gln Pro Val Arg Gln Pro 
                2405                2410                2415    

Gln Gln Val Leu Val His Gln Leu Gln His Gln Arg Val His Arg Leu 
            2420                2425                2430        

Gln His Gln Pro Val Pro Arg Leu Gln Arg Gln Pro Val Arg Gln Leu 
        2435                2440                2445            

Gln Gln Val Pro Val Leu Gln Ser Gln His Gln Gln Val Leu Gln Pro 
    2450                2455                2460                

Gln His Arg Gln Val Pro Arg Leu Gln Gln Ala His Gln His Leu Asn 
2465                2470                2475                2480

Gln Arg Arg Gln Val Arg Arg Pro Gln Pro Val His Leu Asn Arg His 
                2485                2490                2495    

Gln Pro Val Arg Gln Pro Gln Gln Val Leu Val His Gln Leu Gln His 
            2500                2505                2510        

Gln Arg Val His Arg Leu Arg Arg Gln Pro Val His Gln Ser Gln Gln 
        2515                2520                2525            

Val Pro Val Arg Gln Leu Pro His Gln Gln Val Pro Arg Leu Gln Gln 
    2530                2535                2540                

Ala His Gln His Leu Asn Gln Arg Gln Pro Val Leu Arg Leu Gln Gln 
2545                2550                2555                2560

Val Pro Val Leu Gln Leu Gln His Gln Pro Ala Pro Arg Pro Gln Gln 
                2565                2570                2575    

Ala Pro Gln Leu Leu Asn Arg Pro Gln Pro Ala Pro Arg Pro Gln Gln 
            2580                2585                2590        

Ala Pro Gln Leu Leu Asn Arg Pro Gln Pro Ala Pro Gln Pro Gln His 
        2595                2600                2605            

Gln Arg Val Leu Arg Leu Gln Gln Ala Gln Ala Pro Arg Val Gln His 
    2610                2615                2620                

Gln Arg Val Arg Gln Leu Gln Arg Gln Pro Val Leu Gln Pro Gln His 
2625                2630                2635                2640

Gln Gln Val Arg Gln Pro Gln Gln Val Ser Gln Arg Leu Asn Arg His 
                2645                2650                2655    

Gln Arg Val Arg Leu Ser Gln His Gln Arg Val Arg Gln Pro Gln Gln 
            2660                2665                2670        

Ala Pro Gln Leu Leu Asn Arg Pro Gln Pro Val Arg Gln Pro Gln His 
        2675                2680                2685            

Arg Gln Ala Pro Gln Leu Gln Gln Val Pro Val Leu Gln Pro Gln Arg 
    2690                2695                2700                

Arg Gln Val Arg Arg Pro Gln Pro Val His Leu Asn Arg His Gln Pro 
2705                2710                2715                2720

Val Arg Gln Pro Gln Gln Val Leu Val His Arg Leu Gln His Gln Pro 
                2725                2730                2735    

Val Pro Arg Leu Gln Arg Gln Pro Val Arg Gln Leu Gln Gln Val Pro 
            2740                2745                2750        

Val Leu Gln Ser Gln His Gln Gln Val Leu Gln Pro Gln His Arg Gln 
        2755                2760                2765            

Val Pro Arg Leu Gln Gln Ala His Gln His Leu Asn Gln Arg Arg Gln 
    2770                2775                2780                

Ala Pro Gln Leu Gln Gln Val Pro Val Arg Gln Pro Gln Arg Arg Gln 
2785                2790                2795                2800

Val Arg Gln Pro Gln Gln Val Leu Val His Gln Leu Gln His Gln Arg 
                2805                2810                2815    

Val His Arg Leu Arg Arg Gln Pro Val His Gln Ser Gln Gln Val Pro 
            2820                2825                2830        

Val Arg Gln Leu Pro His Gln Gln Val Pro Arg Leu Gln Gln Ala Pro 
        2835                2840                2845            

Val Arg Arg Leu Gln Gln Val Leu Ala Pro Gln Pro Gln Pro Gln Pro 
    2850                2855                2860                

Val Arg Gln Pro Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Arg 
2865                2870                2875                2880

Val Arg Pro Leu Gln Gln Val Leu Ala Pro Gln Pro Gln Arg Gln Gln 
                2885                2890                2895    

Val His Arg Leu Gln Arg Gln Arg Val Arg Leu Asn Arg His Gln Arg 

            2900                2905                2910        

Val Arg Pro Leu Gln Gln Val Leu Ala Pro Gln Pro Gln Arg Gln Gln 
        2915                2920                2925            

Val His Arg Leu Gln His Gln Arg Val Arg Pro Leu Gln Gln Val Leu 
    2930                2935                2940                

Ala Pro Gln Pro Gln Arg Gln Gln Val His Arg Leu Gln Arg Gln Arg 
2945                2950                2955                2960

Val Arg Leu Ser Gln His Gln Arg Val Arg Gln Pro Gln Gln Ala His 
                2965                2970                2975    

Gln Leu Leu Asn Leu His Gln Pro Val Arg Gln Pro Gln His Arg Gln 
            2980                2985                2990        

Ala Pro Gln Leu Gln Gln Val Pro Val Arg Gln Pro Gln Arg Arg Gln 
        2995                3000                3005            

Val Arg Arg Leu Gln Gln Val Pro Val Arg Gln Pro Gln Gln Val Pro 
    3010                3015                3020                

Val Arg Gln Pro Gln Arg Arg Gln Val Arg Arg Pro Gln Pro Val His 
3025                3030                3035                3040

Leu Asn Arg His Gln Pro Val Arg Gln Pro Gln Gln Val Leu Val His 
                3045                3050                3055    

Gln Leu Gln His Gln Arg Val His Arg Leu Gln His Gln Pro Val His 
            3060                3065                3070        

Gln Ser Gln Gln Val Pro Val Arg Gln Leu Pro His Gln Gln Val Pro 
        3075                3080                3085            

Arg Leu Gln Gln Val Leu Ala Pro Gln Pro Gln Arg Gln Gln Val Leu 
    3090                3095                3100                

Gln Leu Pro Arg Gln Pro Ala Pro Arg Pro Gln Gln Val Ser Gln Arg 
3105                3110                3115                3120

Leu Asn Arg His Gln Gln Val Pro Arg Leu Gln His Gln Arg Val His 
                3125                3130                3135    

Gln Ser Gln Gln Ala Pro Val Arg Arg Pro Gln Gln Ala Pro Ala Arg 
            3140                3145                3150        

Leu Asn Pro His Gln Pro Val Pro Gln Leu Gln Gln Val Pro Gln His 
        3155                3160                3165            

Leu Asn Gln His Gln Gln Val Pro Arg Leu Gln Gln Ala Gln Val Leu 
    3170                3175                3180                

Gln Pro Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Arg Val Arg 
3185                3190                3195                3200

Pro Leu Gln Gln Val Leu Ala Pro Gln His Gln Arg Gln Gln Val Leu 
                3205                3210                3215    

Arg Leu Gln Arg Gln Arg Val Arg Leu Ser Gln His Gln Arg Val Arg 
            3220                3225                3230        

Gln Pro Gln Gln Ala His Gln Leu Leu Asn Leu His Gln Pro Val Arg 
        3235                3240                3245            

Gln Pro Gln His Arg Gln Ala Pro Gln Leu Gln Gln Val Pro Val Arg 
    3250                3255                3260                

Gln Pro Gln Gln Val Pro Val Leu Gln Pro Gln Arg Arg Gln Val Arg 
3265                3270                3275                3280

Arg Pro Gln Pro Val His Leu Asn Arg His Gln Pro Val Arg Gln Pro 
                3285                3290                3295    

Gln Gln Val Leu Ala Pro Gln Pro Gln His Gln Arg Val Arg Pro Leu 
            3300                3305                3310        

Gln Gln Val Leu Val His Gln Leu Gln Gln Val Leu Ala Pro Gln Pro 
        3315                3320                3325            

Gln Arg Arg Gln Ala Pro Gln Leu Gln Gln Val Pro Val Arg Gln Pro 
    3330                3335                3340                

Gln Arg Arg Gln Val Arg Arg Leu Gln Gln Val Pro Gln Arg Leu Asn 
3345                3350                3355                3360

Gln His Gln Gln Val Arg Arg Leu Gln His Gln Arg Val His Gln Leu 
                3365                3370                3375    

Gln His Gln Gln Val Leu Gln Leu Gln Gln Val Pro Val Arg Arg Leu 
            3380                3385                3390        

Gln His Gln Arg Val Leu Gln Ser Gln Arg Gln Pro Val Pro Leu Asn 
        3395                3400                3405            

Pro His Gln Gln Val Pro Arg Leu Gln Gln Ala Pro Val Leu Arg Leu 
    3410                3415                3420                

Gln Arg Gln Arg Val Arg Leu Ser Gln His Gln Arg Val Arg Gln Pro 
3425                3430                3435                3440

Gln Gln Ala His Gln Leu Leu Asn Leu His Gln Pro Val Arg Gln Leu 
                3445                3450                3455    

Pro His Gln Gln Ala Pro Arg Pro Gln Gln Val Gln Val Leu Gln Pro 
            3460                3465                3470        

Gln His Gln Pro Val His Gln Leu Gln Pro Gln Gln Val Leu Gln Pro 
        3475                3480                3485            

Gln Arg Gln Pro Val Pro Arg Leu Gln Gln Val Pro Val Arg Gln Leu 
    3490                3495                3500                

Gln Gln Ala Gln Val Arg Gln Leu Gln His Gln Pro Val Leu Arg Leu 
3505                3510                3515                3520

Arg His Gln Gln Val Pro Gln His Gln His Gln Arg Val Arg Gln Pro 
                3525                3530                3535    

Gln Gln Val Leu Val His Gln His Gln His Gln Pro Val His Gln Pro 
            3540                3545                3550        

Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Arg Val His Gln His 
        3555                3560                3565            

Gln His Gln Arg Val His Arg Leu Gln Arg Gln Pro Val His Gln Ser 
    3570                3575                3580                

Gln Gln Ala Pro Val Arg Arg Leu Gln His Gln Arg Val Pro Gln Pro 
3585                3590                3595                3600

Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Arg Val Arg Gln Pro 
                3605                3610                3615    

Gln Gln Val Leu Val His Arg Leu Gln Gln Ala Pro Val Arg Arg Leu 
            3620                3625                3630        

Gln His Gln Pro Val Pro Gln Pro Gln Gln Val Ser Gln Arg Leu Asn 
        3635                3640                3645            

Arg His Gln Arg Val Arg Gln Pro Gln Gln Val Leu Val His Gln His 
    3650                3655                3660                

Gln His Gln Arg Val His Arg Leu Gln Gln Val Pro Ala Pro Gln Leu 
3665                3670                3675                3680

Gln Gln Ala Pro Val Arg Gln Pro Gln Gln Val Pro Ala Pro Gln Pro 
                3685                3690                3695    

Gln Gln Ala Pro Val Pro Gln Leu Gln Gln Val Pro Val Arg Gln Pro 
            3700                3705                3710        

Gln Arg Arg Gln Val Arg Arg Leu Gln Gln Val Pro Gln Arg Leu Asn 
        3715                3720                3725            

Gln His Gln Arg Val His Gln Leu Gln His Gln Gln Val Leu Gln Leu 
    3730                3735                3740                

Gln Gln Val Ser Gln Arg Leu Asn Arg His Gln Arg Val Arg Pro Leu 
3745                3750                3755                3760


Gln Gln Val Leu Ala Pro Gln His Gln Arg Gln Gln Val Leu Arg Leu 
                3765                3770                3775    

Gln Arg Gln Arg Val Arg Leu Ser Gln His Gln Arg Val Arg Gln Pro 
            3780                3785                3790        

Gln Gln Ala His Gln Leu Leu Asn Leu His Gln Pro Val Arg Gln Pro 
        3795                3800                3805            

Gln His Arg Gln Ala Pro Gln Leu Gln Gln Val Pro Val Arg Gln Pro 
    3810                3815                3820                

Gln Gln Val Pro Val Leu Gln Pro Gln Arg Arg Gln Val Arg Arg Pro 
3825                3830                3835                3840

Gln Pro Val His Leu Asn Arg His Gln Pro Val Arg Gln Pro Gln Gln 
                3845                3850                3855    

Val Leu Ala Pro Gln Pro Gln His Gln Arg Val Arg Pro Leu Gln Gln 
            3860                3865                3870        

Val Leu Val His Gln Leu Gln Gln Val Leu Ala Pro Gln Pro Gln Arg 
        3875                3880                3885            

Arg Gln Ala Pro Gln Leu Gln Gln Val Pro Val Arg Gln Pro Gln Arg 
    3890                3895                3900                

Arg Gln Val Arg Arg Leu Gln Gln Val Pro Gln Arg Leu Asn Gln His 
3905                3910                3915                3920

Gln Gln Val Arg Arg Leu Gln His Gln Arg Val His Gln Leu Gln His 
                3925                3930                3935    

Gln Gln Val Leu Gln Leu Gln Gln Val Pro Val Arg Arg Leu Gln His 
            3940                3945                3950        

Gln Arg Val Leu Gln Ser Gln Arg Gln Pro Val Pro Leu Asn Pro His 
        3955                3960                3965            

Gln Gln Val Pro Arg Leu Gln Gln Ala Pro Val Leu Arg Leu Gln Arg 
    3970                3975                3980                

Gln Arg Val Arg Leu Ser Gln His Gln Arg Val Arg Gln Pro Gln Gln 
3985                3990                3995                4000

Ala His Gln Leu Leu Asn Leu His Gln Pro Val Arg Gln Leu Pro His 
                4005                4010                4015    

Gln Gln Ala Pro Arg Pro Gln Gln Val Gln Val Leu Gln Pro Gln His 
            4020                4025                4030        

Gln Pro Val His Gln Leu Gln Pro Gln Gln Val Leu Gln Pro Gln Arg 
        4035                4040                4045            

Gln Pro Val Pro Arg Leu Gln Gln Val Pro Val Arg Gln Leu Gln Gln 
    4050                4055                4060                

Ala Gln Val Arg Gln Leu Gln His Gln Pro Val Leu Arg Leu Arg His 
4065                4070                4075                4080

Gln Gln Val Pro Gln His Gln His Gln Arg Val Arg Gln Pro Gln Gln 
                4085                4090                4095    


Val Leu Val His Gln His Gln His Gln Pro Val His Gln Pro Gln Gln 
            4100                4105                4110        

Val Ser Gln Arg Leu Asn Arg His Gln Arg Val His Gln His Gln His 
        4115                4120                4125            

Gln Arg Val His Arg Leu Gln Arg Gln Pro Val His Gln Ser Gln Gln 
    4130                4135                4140                

Ala Pro Val Arg Arg Leu Gln His Gln Arg Val Pro Gln Pro Gln Gln 
4145                4150                4155                4160

Val Ser Gln Arg Leu Asn Arg His Gln Arg Val Arg Gln Pro Gln Gln 
                4165                4170                4175    

Val Leu Val His Arg Leu Gln Gln Ala Pro Val Arg Arg Leu Gln His 
            4180                4185                4190        

Gln Pro Val Pro Gln Pro Gln Gln Val Ser Gln Arg Leu Asn Arg His 
        4195                4200                4205            

Gln Arg Val Arg Gln Pro Gln Gln Val Leu Val His Gln Pro Gln His 
    4210                4215                4220                

Gln Arg Val His Arg Leu Gln Gln Val Pro Ala Pro Gln Leu Gln Gln 
4225                4230                4235                4240

Ala Pro Val Arg Gln Pro Gln Gln Val Pro Ala Pro Gln Pro Gln Gln 
                4245                4250                4255    

Ala Pro Val Pro Gln Leu Gln Gln Val Pro Val Arg Gln Pro Gln His 
            4260                4265                4270        

Gln Gln Val Leu Gln Leu Arg Pro Gln Gln Val Arg Gln Leu Gln His 
        4275                4280                4285            

Gln Arg Val Arg Arg Leu Gln Gln Ala Pro Val Pro Arg Pro Gln Gln 
    4290                4295                4300                

Ala Pro Val Leu Gln Leu Gln His Gln Gln Val Arg Gln Leu Gln Gln 
4305                4310                4315                4320

Val His Gln Phe Gln Ile Gln Gln Thr Ile Arg Thr His Lys Leu Glu 
                4325                4330                4335    

Ile Leu Leu Asp Arg Gln Val Asn Pro Lys Lys Asn Cys Leu Ile Gln 
            4340                4345                4350        

Val Leu Ser Arg Gln Leu Asp Leu Cys Tyr Leu Glu Phe 
        4355                4360                4365

<210>   3661
<211>   14328
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3661
atgaccgaaa cggtagaaga taaagtaagt cattcaatta ctgggcttga tatcctcaag   60
gggatagttg ctgcgggagc tgtcataagt ggaaccgttg caactcaaac gaaggtattt   120
acaaatgagt cagcagtact tgaaaaaact gtagagaaaa cggatgcttt ggcaacaaat   180
gatacagtag ttctaggtac gatatctaca agtaattcag cgagttcaac tagtttgtca   240
gcttcagagt cggcaagtac atctgcatct gagtcagcct caaccagcgc ttcgacctca   300
gcaagtacaa gtgcatcaga atcagcaagt acatcggctt cgacaagtat ttctgcatca   360
tctactgtgg taggttcaca aacagctgcc gctacagaag caactgctaa gaaggtcgaa   420
gaagatcgta agaaaccagc tagtgattat gtagcatcag ttacaaatgt caatctccaa   480
tcttatgcta agcgacgcaa gcgttcagtg gattccatcg agcaattgct ggcttctata   540
aaaaatgctg ctgttttttc tggcaatacg attgtaaatg gcgcccctgc aattaatgca   600
agtctaaaca ttgctaaaag tgagacaaaa gtttatacag gtgaaggtgt agattcggta   660
tatcgtgttc caatttacta taaattgaaa gtgacaaatg atggttcaaa attgaccttt   720
acctatacgg ttacgtatgt gaatcctaaa acaaatgatc ttggtaatat atcaagtatg   780
cgtcctggat attctatcta taattcaggt acttcaacac aaacaatgtt aacccttggc   840
agtgatcttg gtaaaccttc aggtgtaaag aactacatta ctgacaaaaa tggtagacag   900
gttctatcct ataatacatc tacaatgacg acgcagggta gtgggtatac ttggggaaat   960
ggtgcccaaa tgaatggttt ctttgctaag aaaggatatg gattaacatc atcttggact   1020
gtaccaatta ctggaacgga tacatccttt acatttaccc cttacgctgc tagaacagat   1080
agaattggaa ttaactactt caatggtgga ggaaaggtag ttgaatctag cacgaccagt   1140
cagtcacttt cacagtctaa gtcactctca gtaagtgcta gtcaaagcgc ctcagcttca   1200
gcatcaacaa gtgcgtcggc ttcagcatca accagtgcct cggcttcagc gtcaaccagt   1260
gcgtcagctt cagcaagtac cagtgcttca gtctcagcat caacaagtgc ttcagcctca   1320
gcatcgacaa gtgcctcggc ttcagcaagc acatcagcat ctgaatcagc gtcaaccagt   1380
gcttcggctt cagcaagtac cagtgcttca gcttcagcat caaccagcgc ctcggcctca   1440
gcaagcacct cagcttctga atcggcctca accagcgcct cggcctcagc aagcacctca   1500
gcttctgaat cggcctcaac cagcgcctca gcctcagcat caacgagtgc ttcggcttca   1560
gcaagcacaa gcgcctcggg ttcagcatca acgagtacgt cagcttcagc gtcaaccagt   1620
gcttcagcct cagcatcaac aagtgcgtca gcctcagcaa gtatctcagc gtctgaatcg   1680
gcatcaacga gtgcgtctga gtcagcatca acgagtacgt cagcctcagc aagcacctca   1740
gcttctgaat cggcctcaac cagtgcgtca gcctcagcat cgacaagcgc ctcagcttca   1800
gcaagtacca gtgcttcagc ctcagcgtcg acaagtgcgt cggcctcaac cagtgcatct   1860
gaatcggcat caaccagtgc gtcagcctca gcaagtacta gtgcatcggc ttcagcatca   1920
accagtgcct cggcttcagc gtcaaccagt gcgtcagctt cagcaagtac cagtgcttca   1980
gtctcagcat caacaagtgc ttcagcctca gcatcgacaa gtgcctcggc ttcagcaagc   2040
acatcagcat ctgaatcagc gtcgacaagc gcctcagctt cagcaagtac cagtgcgtca   2100
gcctcagcgt cgacaagtgc gtcagcctca gcaagtacta gtgcatcagc ttcagcatca   2160
acgagtgcat cggcttcggc gtcaaccagt gcatcagagt cagcaagtac cagtgcgtca   2220
gcttccgcat caacaagtgc ctcggcttca gcaagcacca gtgcgtcggc ttcagcaagt   2280
actagcgcct cagcctcagc ctcaaccagt gcgtcagcct cagcaagtat ctcagcgtct   2340
gaatcggcat caacgagtgc gtccgcttca gcaagtacta gcgcctcagc ctcagcgtca   2400
acaagtgcat cggcttcagc gtcaacgagt gcgtctgaat cggcatcaac gagtgcgtcc   2460
gcttcagcaa gtactagcgc ctcagcctca gcgtcaacaa gtgcatcggc ttcagcatca   2520
acgagtgcgt ccgcttcagc aagtactagc gcctcagcct cagcgtcaac aagtgcatcg   2580
gcttcagcgt caacgagtgc gtctgagtca gcatcaacga gtgcgtcagc ctcagcaagc   2640
acatcagctt ctgaatctgc atcaaccagt gcgtcagcct cagcatcgac aagcgcctca   2700
gcttcagcaa gtaccagtgc gtcagcctca gcgtcgacaa gtgcgtcggc ttcagcaagt   2760
accagtgcgt cagcctcagc aagtaccagt gcgtcagcct cagcgtcgac aagtgcgtcg   2820
gcctcaacca gtgcatctga atcggcatca accagtgcgt cagcctcagc aagtactagt   2880
gcatcagctt cagcatcaac gagtgcatcg gcttcagcat caaccagtgc atcagagtca   2940
gcaagtacca gtgcgtcagc ttccgcatca acaagtgcct cggcttcagc aagtactagc   3000
gcctcagcct cagcgtcaac aagtgcttca gcttccgcgt caaccagcgc ctcggcctca   3060
gcaagtatct cagcgtctga atcggcatca acaagtgcct cggcttcagc atcaacgagt   3120
gcatcagtct cagcaagcac cagtgcgtcg gcctcagcaa gcaccagcgc gtctgaatcc   3180
gcatcaacca gtgcctcagc ttcagcaagt acctcagcat ctgaatcagc atcaacaagt   3240
gcctcggctt cagcaagcac aagtgcttca gcctcagcaa gtatctcagc gtctgaatcg   3300
gcatcaacga gtgcgtccgc ttcagcaagt actagcgcct cagcatcagc gtcaacaagt   3360
gcttcggctt cagcgtcaac gagtgcgtct gagtcagcat caacgagtac gtcagcctca   3420
gcaagcacat cagcttctga atctgcatca accagtgcgt cagcctcagc atcgacaagc   3480
gcctcagctt cagcaagtac cagtgcgtca gcctcagcaa gtaccagtgc ttcagcctca   3540
gcgtcgacaa gtgcgtcggc ctcaaccagt gcatctgaat cggcatcaac cagtgcgtca   3600
gcctcagcaa gtactagcgc ctcagcctca gcatcaacga gtgcgtccgc ttcagcaagt   3660
actagtgcat cagcttcagc aagtactagc gcctcagcct cagcgtcgac aagcgcctca   3720
gcttcagcaa gtaccagtgc gtcagcctca gcgtcgacaa gtgcgtcggc ttcagcaagt   3780
acctcagcgt ctgaatcagc atcaacaagt gcgtcggctt cagcatcaac gagtgcatca   3840
gcttcagcat caacaagtgc ttcagcttca gcaagtacca gtgcgtcggc ttcagcatca   3900
acgagtgctt cagtctcagc gtcaaccagt gcctctgaat ccgcatcaac aagtgcctcg   3960
gcttcagcaa gcaccagtgc ttcggcttca gcgtcaacga gtgcgtctga gtcagcatca   4020
acgagtgcgt cagcctcagc aagcacatca gcttctgaat ctgcatcaac cagtgcgtca   4080
gcttccgcat caacaagcgc ctcggcctca gcaagtacaa gtgcttcagc ctcagcatca   4140
accagtgcat cagcttcagc ctcaacaagt gcttcagcct cagcgtcaac cagtgcctcg   4200
gcttcagcaa gtaccagtgc gtcagcttca gcaagcacaa gtgcgtcagc ttcagcatca   4260
accagtgctt cggcttcggc atcaacaagt gcctcagcat cagcatcaac gagtgcgtca   4320
gcctcagcaa gtactagtgc atcagcatca gcatcaacca gtgcatcagc ctcagcaagt   4380
atctcagcgt ctgaatcggc atcaacgagt gcatcagcat cagcatcaac gagtgcatcg   4440
gcttcagcgt caaccagtgc atcagtctca gcaagcacca gtgcgtcggc ttcagcatca   4500
acgagtgcct cagcctcagc aagtatctca gcgtctgaat cggcatcaac gagtgcgtca   4560
gcctcagcaa gtactagtgc atcggcttca gcaagcacca gtgcgtcggc ttcagcatca   4620
accagtgcct cagcctcagc aagtatctca gcgtctgaat cggcatcaac gagtgcgtca   4680
gcctcagcaa gtactagtgc atcagcatca gcatcaacga gtgcatcggc ttcagcaagt   4740
accagcgcct cagcttcagc aagcaccagt gcgtcagcct cagcaagtac cagcgcctca   4800
gcctcagcaa gcaccagtgc ctcagcttca gcaagtacca gtgcgtcagc ctcagcgtcg   4860
acaagtgcgt cggcttcagc aagtacctca gcgtctgaat cagcatcaac gagtgcatca   4920
gcttcagcat caacaagtgc ttcagcttca gcaagtacca gtgcgtcggc ttcagcatca   4980
acgagtgctt cagtctcagc gtcaaccagt gcctctgaat cagcatcaac aagtgcctcg   5040
gcttcagcaa gcaccagtgc gtcggcttca gcaagtacta gtgcatcggc ttcagcatcg   5100
acaagtgcgt ctgaatcggc atcaacgagt gcttcggctt cagcatcaac gagtgcgtca   5160
gcctcagcaa gcacatcagc ttctgaatct gcatcaacca gtgcgtccgc ttcagcgtca   5220
accagtgcgt cggcttcagc gtcgacaagt gcttcggctt cagcatcaac gagtgcgtcg   5280
gcctcagcaa gcgcaagtac ctcagcgtca gcttccgcct caaccagtgc gtcggcttca   5340
gcaagcacaa gtgcgtcagc ctcagcaagt atctcagcgt ctgaatcggc atcaacgagt   5400
gcgtctgagt cagcatcaac gagtacgtca gcctcagcaa gcacatcagc ttctgaatct   5460
gcatcaacca gtgcgtcagc ctcagcatcg acaagcgcct cagcttcagc aagtaccagt   5520
gcttcagcct cagcgtcgac aagtgcgtcg gcctcaacca gtgcatctga atcggcatca   5580
accagtgcgt cagcctcagc aagtactagt gcatcagctt cagcatcaac gagtgcatcg   5640
gcttcagcat caaccagtgc ctcggcttca gcgtcaacca gtgcgtcagc ttcagcaagt   5700
accagtgctt cagtctcagc atcaacaagt gcttcagcct cagcatcgac aagtgcctcg   5760
gcttcagcaa gcacatcagc atctgaatca gcgtcgacaa gcgcctcagc ttcagcaagt   5820
accagtgcgt cagcctcagc gtcgacaagt gcgtcagcct cagcaagtac tagtgcatca   5880
gcttcagcat caacgagtgc atcggcttcg gcgtcaacca gtgcatcaga gtcagcaagt   5940
accagtgcgt cagcttccgc atcaacaagt gcctcggctt cagcaagcac cagtgcgtcg   6000
gcttcagcaa gtactagcgc ctcagcctca gcctcaacca gtgcgtcagc ctcagcaagt   6060
atctcagcgt ctgaatcggc atcaacgagt gcgtccgctt cagcaagtac tagcgcctca   6120
gcctcagcgt caacaagtgc atcggcttca gcgtcaacga gtgcgtctga atcggcatca   6180
acgagtgcgt ccgcttcagc aagtactagc gcctcagcct cagcgtcaac aagtgcatcg   6240
gcttcagcat caacgagtgc gtccgcttca gcaagtacta gcgcctcagc ctcagcgtca   6300
acaagtgcat cggcttcagc gtcaacgagt gcgtctgagt cagcatcaac gagtgcgtca   6360
gcctcagcaa gcacatcagc ttctgaatct gcatcaacca gtgcgtcagc ctcagcatcg   6420
acaagcgcct cagcttcagc aagtaccagt gcgtcagcct cagcgtcgac aagtgcgtcg   6480
gcttcagcaa gtaccagtgc gtcagcctca gcaagtacca gtgcgtcagc ctcagcgtcg   6540
acaagtgcgt cggcctcaac cagtgcatct gaatcggcat caaccagtgc gtcagcctca   6600
gcaagtacta gtgcatcagc ttcagcatca acgagtgcat cggcttcagc atcaaccagt   6660
gcatcagagt cagcaagtac cagtgcgtca gcttccgcat caacaagtgc ctcggcttca   6720
gcaagtacta gcgcctcagc ctcagcgtca acaagtgctt cagcttccgc gtcaaccagc   6780
gcctcggcct cagcaagtat ctcagcgtct gaatcggcat caacaagtgc ctcggcttca   6840
gcatcaacga gtgcatcagt ctcagcaagc accagtgcgt cggcctcagc aagcaccagc   6900
gcgtctgaat ccgcatcaac cagtgcctca gcttcagcaa gtacctcagc atctgaatca   6960
gcatcaacaa gtgcatcggc ttcagcaagc acaagtgctt cagcctcagc aagtatctca   7020
gcgtctgaat cggcatcaac gagtgcgtcc gcttcagcaa gtactagcgc ctcagcatca   7080
gcgtcaacaa gtgcttcggc ttcagcgtca acgagtgcgt ctgagtcagc atcaacgagt   7140
acgtcagcct cagcaagcac atcagcttct gaatctgcat caaccagtgc gtcagcctca   7200
gcatcgacaa gcgcctcagc ttcagcaagt accagtgcgt cagcctcagc aagtaccagt   7260
gcttcagcct cagcgtcgac aagtgcgtcg gcctcaacca gtgcatctga atcggcatca   7320
accagtgcgt cagcctcagc aagtactagc gcctcagcct cagcatcaac gagtgcgtcc   7380
gcttcagcaa gtactagtgc atcagcatca gcatcaacga gtgcatcggc ttcagcaagt   7440
accagcgcct cagcttcagc aagcaccagt gcgtcagcct cagcaagtac cagcgcctca   7500
gcctcagcaa gcaccagtgc ctcagcttca gcaagtacca gtgcgtcagc ctcagcgtcg   7560
acaagtgcgt cggcttcagc aagtacctca gcgtctgaat cagcatcaac gagtgcatca   7620
gcttcagcat caacaagtgc ttcagcttca gcaagtacca gtgcgtcggc ttcagcatca   7680
acgagtgctt cagtctcagc gtcaaccagt gcctctgaat cagcatcaac aagtgcctcg   7740
gcttcagcaa gcaccagtgc gtcggcttca gcaagtacta gtgcatcggc ttcagcatcg   7800
acaagtgcgt ctgaatcggc atcaacgagt gcttcggctt cagcatcaac gagtgcgtca   7860
gcctcagcaa gcacatcagc ttctgaatct gcatcaacca gtgcgtccgc ttcagcgtca   7920
accagtgcgt cggcttcagc gtcgacaagt gcttcggctt cagcatcaac gagtgcgtcg   7980
gcctcagcaa gcgcaagtac ctcagcgtca gcttccgcct caaccagtgc gtccgcttca   8040
gcaagcacaa gtgcgtcagc ctcagcaagt atctcagcgt ctgaatcggc atcaacgagt   8100
gcgtcggcct cagcaagcgc aagtacctca gcgtcagctt ccgcctcaac cagtgcgtcg   8160
gcttcagcaa gcacaagtgc gtcagcctca gcaagtatct cagcgtctga atcggcatca   8220
acgagtgcgt ctgagtcagc atcaacgagt acgtcagcct cagcaagcac atcagcttct   8280
gaatcggcat caaccagtgc gtcagcctca gcatcgacaa gcgcctcagc ttcagcaagt   8340
accagtgctt cagcctcagc gtcgacaagt gcgtcggcct caaccagtgc atctgaatcg   8400
gcatcaacca gtgcgtcagc ctcagcaagt actagtgcat cagcttcagc atcaacgagt   8460
gcatcggctt cagcatcaac cagtgcctcg gcttcagcgt caaccagtgc gtcagcttca   8520
gcaagtacca gtgcttcagt ctcagcatca acaagtgctt cagcctcagc atcgacaagt   8580
gcctcggctt cagcaagcac atcagcatct gaatcagcgt cgacaagtgc gtcggcctca   8640
accagtgcat ctgaatcggc atcaaccagt gcgtcagcct cagcaagtac tagtgcatca   8700
gcttcagcat caacgagtgc atcggcttcg gcgtcaacca gtgcatcaga gtcagcaagt   8760
accagtgcgt cagcttccgc atcaacaagt gcctcggctt cagcaagcac atcagcatct   8820
gaatcagcgt caaccagtgc ttcggcttca gcaagtacca gtgcttcagc ttcagcatca   8880
accagcgcct cggcctcagc aagcacctca gcttctgaat cggcctcaac cagcgcctcg   8940
gcctcagcaa gcacctcagc ttctgaatcg gcctcaacca gcgcctcagc ctcagcatca   9000
acgagtgctt cggcttcagc aagcacaagc gcctcgggtt cagcatcaac gagtacgtca   9060
gcttcagcgt caaccagtgc ttcagcctca gcatcaacaa gtgcgtcagc ctcagcaagt   9120
atctcagcgt ctgaatcggc atcaacgagt gcgtctgagt cagcatcaac gagtacgtca   9180
gcctcagcaa gcacctcagc ttctgaatcg gcctcaacca gtgcgtcagc ctcagcatcg   9240
acaagcgcct cagcttcagc aagtaccagt gcttcagcct cagcgtcgac aagtgcgtcg   9300
gcctcaacca gtgcatctga atcggcatca accagtgcgt cagcctcagc aagtactagt   9360
gcatcggctt cagcatcaac cagtgcctcg gcttcagcgt caaccagtgc gtcagcttca   9420
gcaagtacca gtgcttcagt ctcagcatca acaagtgctt cagcctcagc atcgacaagt   9480
gcctcggctt cagcaagcac atcagcatct gaatcagcgt cgacaagcgc ctcagcttca   9540
gcaagtacca gtgcgtcagc ctcagcgtcg acaagtgcgt cagcctcagc aagtactagt   9600
gcatcagctt cagcatcaac gagtgcatcg gcttcggcgt caaccagtgc atcagagtca   9660
gcaagtacca gtgcgtcagc ttccgcatca acaagtgcct cggcttcagc aagcaccagt   9720
gcgtcggctt cagcaagtac tagcgcctca gcctcagcct caaccagtgc gtcagcctca   9780
gcaagtatct cagcgtctga atcggcatca acgagtgcgt ccgcttcagc aagtactagc   9840
gcctcagcct cagcgtcaac aagtgcatcg gcttcagcgt caacgagtgc gtctgaatcg   9900
gcatcaacga gtgcgtccgc ttcagcaagt actagcgcct cagcctcagc gtcaacaagt   9960
gcatcggctt cagcatcaac gagtgcgtcc gcttcagcaa gtactagcgc ctcagcctca   10020
gcgtcaacaa gtgcatcggc ttcagcgtca acgagtgcgt ctgagtcagc atcaacgagt   10080
gcgtcagcct cagcaagcac atcagcttct gaatctgcat caaccagtgc gtcagcctca   10140
gcatcgacaa gcgcctcagc ttcagcaagt accagtgcgt cagcctcagc gtcgacaagt   10200
gcgtcggctt cagcaagtac cagtgcgtca gcctcagcaa gtaccagtgc gtcagcctca   10260
gcgtcgacaa gtgcgtcggc ctcaaccagt gcatctgaat cggcatcaac cagtgcgtca   10320
gcctcagcaa gtactagtgc atcagcttca gcatcaacga gtgcatcggc ttcagcatca   10380
accagtgcat cagagtcagc aagtaccagt gcgtcagctt ccgcatcaac aagtgcctcg   10440
gcttcagcaa gtactagcgc ctcagcctca gcgtcaacaa gtgcttcagc ttccgcgtca   10500
accagcgcct cggcctcagc aagtatctca gcgtctgaat cggcatcaac aagtgcctcg   10560
gcttcagcat caacgagtgc atcagtctca gcaagcacca gtgcgtcggc ctcagcaagc   10620
accagcgcgt ctgaatccgc atcaaccagt gcctcagctt cagcaagtac ctcagcatct   10680
gaatcagcat caacaagtgc ctcggcttca gcaagcacaa gtgcttcagc ctcagcaagt   10740
atctcagcgt ctgaatcggc atcaacgagt gcgtccgctt cagcaagtac tagcgcctca   10800
gcatcagcgt caacaagtgc ttcggcttca gcgtcaacga gtgcgtctga gtcagcatca   10860
acgagtacgt cagcctcagc aagcacatca gcttctgaat ctgcatcaac cagtgcgtca   10920
gcctcagcat cgacaagcgc ctcagcttca gcaagtacca gtgcgtcagc ctcagcaagt   10980
accagtgctt cagcctcagc gtcgacaagt gcgtcggcct caaccagtgc atctgaatcg   11040
gcatcaacca gtgcgtcagc ctcagcaagt actagcgcct cagcctcagc atcaacgagt   11100
gcgtccgctt cagcaagtac tagtgcatca gcttcagcaa gtactagcgc ctcagcctca   11160
gcgtcgacaa gcgcctcagc ttcagcaagt accagtgcgt cagcctcagc gtcgacaagt   11220
gcgtcggctt cagcaagtac ctcagcgtct gaatcagcat caacaagtgc gtcggcttca   11280
gcatcaacga gtgcatcagc ttcagcatca acaagtgctt cagcttcagc aagtaccagt   11340
gcgtcggctt cagcatcaac gagtgcttca gtctcagcgt caaccagtgc ctctgaatcc   11400
gcatcaacaa gtgcctcggc ttcagcaagc accagtgctt cggcttcagc gtcaacgagt   11460
gcgtctgagt cagcatcaac gagtgcgtca gcctcagcaa gcacatcagc ttctgaatct   11520
gcatcaacca gtgcgtcagc ttccgcatca acaagcgcct cggcctcagc aagtacaagt   11580
gcttcagcct cagcatcaac cagtgcatca gcttcagcct caacaagtgc ttcagcctca   11640
gcgtcaacca gtgcctcggc ttcagcaagt accagtgcgt cagcttcagc aagcacaagt   11700
gcgtcagctt cagcatcaac cagtgcttcg gcttcggcat caacaagtgc ctcagcatca   11760
gcatcaacga gtgcgtcagc ctcagcaagt actagtgcat cagcatcagc atcaaccagt   11820
gcatcagcct cagcaagtat ctcagcgtct gaatcggcat caacgagtgc atcagcatca   11880
gcatcaacga gtgcatcggc ttcagcgtca accagtgcat cagtctcagc aagcaccagt   11940
gcgtcggctt cagcatcaac gagtgcctca gcctcagcaa gtatctcagc gtctgaatcg   12000
gcatcaacga gtgcgtcagc ctcagcaagt actagtgcat cggcttcagc aagcaccagt   12060
gcgtcggctt cagcatcaac cagtgcctca gcctcagcaa gtatctcagc gtctgaatcg   12120
gcatcaacga gtgcgtcagc ctcagcaagt actagtgcat cagcatcagc atcaacgagt   12180
gcatcggctt cagcaagtac cagcgcctca gcttcagcaa gcaccagtgc gtcagcctca   12240
gcaagtacca gcgcctcagc ctcagcaagc accagtgcct cagcttcagc aagtaccagt   12300
gcgtcagcct cagcgtcgac aagtgcgtcg gcttcagcaa gtacctcagc gtctgaatca   12360
gcatcaacga gtgcatcagc ttcagcatca acaagtgctt cagcttcagc aagtatctca   12420
gcgtctgaat cggcatcaac gagtgcgtcc gcttcagcaa gtactagcgc ctcagcatca   12480
gcgtcaacaa gtgcttcggc ttcagcgtca acgagtgcgt ctgagtcagc atcaacgagt   12540
acgtcagcct cagcaagcac atcagcttct gaatctgcat caaccagtgc gtcagcctca   12600
gcatcgacaa gcgcctcagc ttcagcaagt accagtgcgt cagcctcagc aagtaccagt   12660
gcttcagcct cagcgtcgac aagtgcgtcg gcctcaacca gtgcatctga atcggcatca   12720
accagtgcgt cagcctcagc aagtactagc gcctcagcct cagcatcaac gagtgcgtcc   12780
gcttcagcaa gtactagtgc atcagcttca gcaagtacta gcgcctcagc ctcagcgtcg   12840
acaagcgcct cagcttcagc aagtaccagt gcgtcagcct cagcgtcgac aagtgcgtcg   12900
gcttcagcaa gtacctcagc gtctgaatca gcatcaacaa gtgcgtcggc ttcagcatca   12960
acgagtgcat cagcttcagc atcaacaagt gcttcagctt cagcaagtac cagtgcgtcg   13020
gcttcagcat caacgagtgc ttcagtctca gcgtcaacca gtgcctctga atccgcatca   13080
acaagtgcct cggcttcagc aagcaccagt gcttcggctt cagcgtcaac gagtgcgtct   13140
gagtcagcat caacgagtgc gtcagcctca gcaagcacat cagcttctga atctgcatca   13200
accagtgcgt cagcttccgc atcaacaagc gcctcggcct cagcaagtac aagtgcttca   13260
gcctcagcat caaccagtgc atcagcttca gcctcaacaa gtgcttcagc ctcagcgtca   13320
accagtgcct cggcttcagc aagtaccagt gcgtcagctt cagcaagcac aagtgcgtca   13380
gcttcagcat caaccagtgc ttcggcttcg gcatcaacaa gtgcctcagc atcagcatca   13440
acgagtgcgt cagcctcagc aagtactagt gcatcagcat cagcatcaac cagtgcatca   13500
gcctcagcaa gtatctcagc gtctgaatcg gcatcaacga gtgcatcagc atcagcatca   13560
acgagtgcat cggcttcagc gtcaaccagt gcatcagtct cagcaagcac cagtgcgtcg   13620
gcttcagcat caacgagtgc ctcagcctca gcaagtatct cagcgtctga atcggcatca   13680
acgagtgcgt cagcctcagc aagtactagt gcatcggctt cagcaagcac cagtgcgtcg   13740
gcttcagcat caaccagtgc ctcagcctca gcaagtatct cagcgtctga atcggcatca   13800
acgagtgcgt cagcctcagc aagtactagt gcatcagcct cagcatcaac gagtgcatcg   13860
gcttcagcaa gtaccagcgc ctcagcttca gcaagcacca gtgcgtcagc ctcagcaagt   13920
accagcgcct cagcctcagc aagcaccagt gcctcagctt cagcaagtac cagtgcgtca   13980
gcctcagcat caacaagtgc ttcagcttcg gcctcaacaa gtgcgtcagc ttcagcatca   14040
acgagtgcgt cggcttcagc aagcaccagt gcctcggcct cagcaagcac cagtgcttca   14100
gcttcagcat caacaagtgc gtcagcttca gcaagtacat cagtttcaaa ttcagcaaac   14160
cattcgaact cacaagttgg aaatacttct ggatcgacag gtaaatccca aaaagaattg   14220
cctaatacag gtactgagtc gtcaattgga tctgtgttac ttggagttct agcagctgtt   14280
acaggtattg gattggttgc gaaacgccgt aaacgtgatg aagaagag                14328

<210>   3662
<211>   4776
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell wall surface anchor family protein
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15903446 (9.E-10)

<400>   3662
Met Thr Glu Thr Val Glu Asp Lys Val Ser His Ser Ile Thr Gly Leu 
1               5                   10                  15      

Asp Ile Leu Lys Gly Ile Val Ala Ala Gly Ala Val Ile Ser Gly Thr 
            20                  25                  30          

Val Ala Thr Gln Thr Lys Val Phe Thr Asn Glu Ser Ala Val Leu Glu 
        35                  40                  45              

Lys Thr Val Glu Lys Thr Asp Ala Leu Ala Thr Asn Asp Thr Val Val 
    50                  55                  60                  

Leu Gly Thr Ile Ser Thr Ser Asn Ser Ala Ser Ser Thr Ser Leu Ser 
65                  70                  75                  80  

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
                85                  90                  95      

Ala Ser Thr Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
            100                 105                 110         

Ala Ser Thr Ser Ile Ser Ala Ser Ser Thr Val Val Gly Ser Gln Thr 
        115                 120                 125             

Ala Ala Ala Thr Glu Ala Thr Ala Lys Lys Val Glu Glu Asp Arg Lys 
    130                 135                 140                 

Lys Pro Ala Ser Asp Tyr Val Ala Ser Val Thr Asn Val Asn Leu Gln 
145                 150                 155                 160 

Ser Tyr Ala Lys Arg Arg Lys Arg Ser Val Asp Ser Ile Glu Gln Leu 
                165                 170                 175     

Leu Ala Ser Ile Lys Asn Ala Ala Val Phe Ser Gly Asn Thr Ile Val 
            180                 185                 190         

Asn Gly Ala Pro Ala Ile Asn Ala Ser Leu Asn Ile Ala Lys Ser Glu 
        195                 200                 205             

Thr Lys Val Tyr Thr Gly Glu Gly Val Asp Ser Val Tyr Arg Val Pro 
    210                 215                 220                 

Ile Tyr Tyr Lys Leu Lys Val Thr Asn Asp Gly Ser Lys Leu Thr Phe 
225                 230                 235                 240 

Thr Tyr Thr Val Thr Tyr Val Asn Pro Lys Thr Asn Asp Leu Gly Asn 
                245                 250                 255     

Ile Ser Ser Met Arg Pro Gly Tyr Ser Ile Tyr Asn Ser Gly Thr Ser 
            260                 265                 270         

Thr Gln Thr Met Leu Thr Leu Gly Ser Asp Leu Gly Lys Pro Ser Gly 
        275                 280                 285             

Val Lys Asn Tyr Ile Thr Asp Lys Asn Gly Arg Gln Val Leu Ser Tyr 
    290                 295                 300                 

Asn Thr Ser Thr Met Thr Thr Gln Gly Ser Gly Tyr Thr Trp Gly Asn 
305                 310                 315                 320 

Gly Ala Gln Met Asn Gly Phe Phe Ala Lys Lys Gly Tyr Gly Leu Thr 
                325                 330                 335     

Ser Ser Trp Thr Val Pro Ile Thr Gly Thr Asp Thr Ser Phe Thr Phe 
            340                 345                 350         

Thr Pro Tyr Ala Ala Arg Thr Asp Arg Ile Gly Ile Asn Tyr Phe Asn 
        355                 360                 365             

Gly Gly Gly Lys Val Val Glu Ser Ser Thr Thr Ser Gln Ser Leu Ser 
    370                 375                 380                 

Gln Ser Lys Ser Leu Ser Val Ser Ala Ser Gln Ser Ala Ser Ala Ser 
385                 390                 395                 400 

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                405                 410                 415     

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser 
            420                 425                 430         

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        435                 440                 445             

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    450                 455                 460                 

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
465                 470                 475                 480 

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                485                 490                 495     

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            500                 505                 510         

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Gly Ser 
        515                 520                 525             

Ala Ser Thr Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    530                 535                 540                 

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
545                 550                 555                 560 

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Thr Ser Ala Ser 
                565                 570                 575     

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            580                 585                 590         

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        595                 600                 605             

Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
    610                 615                 620                 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
625                 630                 635                 640 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                645                 650                 655     

Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            660                 665                 670         

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
        675                 680                 685             

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    690                 695                 700                 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
705                 710                 715                 720 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                725                 730                 735     

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            740                 745                 750         

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        755                 760                 765             

Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser 
    770                 775                 780                 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
785                 790                 795                 800 

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                805                 810                 815     

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            820                 825                 830         

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        835                 840                 845             

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    850                 855                 860                 

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
865                 870                 875                 880 

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                885                 890                 895     

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            900                 905                 910         

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        915                 920                 925             

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser 
    930                 935                 940                 

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
945                 950                 955                 960 

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                965                 970                 975     

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            980                 985                 990         

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        995                 1000                1005            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser 
    1010                1015                1020                

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
1025                1030                1035                1040

Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                1045                1050                1055    

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            1060                1065                1070        

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        1075                1080                1085            

Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser 
    1090                1095                1100                

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
1105                1110                1115                1120

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
                1125                1130                1135    

Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
            1140                1145                1150        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        1155                1160                1165            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
    1170                1175                1180                

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
1185                1190                1195                1200

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1205                1210                1215    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1220                1225                1230        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1235                1240                1245            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1250                1255                1260                

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1265                1270                1275                1280

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1285                1290                1295    

Ala Ser Ala Ser Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser 
            1300                1305                1310        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1315                1320                1325            

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
    1330                1335                1340                

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
1345                1350                1355                1360

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1365                1370                1375    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1380                1385                1390        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1395                1400                1405            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1410                1415                1420                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1425                1430                1435                1440

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1445                1450                1455    

Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            1460                1465                1470        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1475                1480                1485            

Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1490                1495                1500                

Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
1505                1510                1515                1520

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1525                1530                1535    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser 
            1540                1545                1550        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1555                1560                1565            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1570                1575                1580                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1585                1590                1595                1600

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1605                1610                1615    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1620                1625                1630        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1635                1640                1645            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1650                1655                1660                

Val Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
1665                1670                1675                1680

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1685                1690                1695    

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            1700                1705                1710        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1715                1720                1725            

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1730                1735                1740                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1745                1750                1755                1760

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                1765                1770                1775    

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser 
            1780                1785                1790        

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
        1795                1800                1805            

Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
    1810                1815                1820                

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
1825                1830                1835                1840

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                1845                1850                1855    

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1860                1865                1870        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1875                1880                1885            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    1890                1895                1900                

Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1905                1910                1915                1920

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
                1925                1930                1935    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            1940                1945                1950        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        1955                1960                1965            

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
    1970                1975                1980                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
1985                1990                1995                2000

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                2005                2010                2015    

Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            2020                2025                2030        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        2035                2040                2045            

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
    2050                2055                2060                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
2065                2070                2075                2080

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                2085                2090                2095    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            2100                2105                2110        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        2115                2120                2125            

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    2130                2135                2140                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
2145                2150                2155                2160

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                2165                2170                2175    

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
            2180                2185                2190        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        2195                2200                2205            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
    2210                2215                2220                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
2225                2230                2235                2240

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                2245                2250                2255    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
            2260                2265                2270        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser 
        2275                2280                2285            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
    2290                2295                2300                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
2305                2310                2315                2320

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                2325                2330                2335    

Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            2340                2345                2350        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        2355                2360                2365            

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Thr Ser Ala Ser 
    2370                2375                2380                

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
2385                2390                2395                2400

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                2405                2410                2415    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            2420                2425                2430        

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        2435                2440                2445            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    2450                2455                2460                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
2465                2470                2475                2480

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                2485                2490                2495    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            2500                2505                2510        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        2515                2520                2525            

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    2530                2535                2540                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
2545                2550                2555                2560

Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                2565                2570                2575    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            2580                2585                2590        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
        2595                2600                2605            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    2610                2615                2620                

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
2625                2630                2635                2640

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                2645                2650                2655    

Thr Ser Ala Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            2660                2665                2670        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        2675                2680                2685            

Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    2690                2695                2700                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
2705                2710                2715                2720

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser 
                2725                2730                2735    

Glu Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Thr Ser 
            2740                2745                2750        

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
        2755                2760                2765            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    2770                2775                2780                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
2785                2790                2795                2800

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                2805                2810                2815    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            2820                2825                2830        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser 
        2835                2840                2845            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    2850                2855                2860                

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
2865                2870                2875                2880

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                2885                2890                2895    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            2900                2905                2910        

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        2915                2920                2925            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
    2930                2935                2940                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
2945                2950                2955                2960

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                2965                2970                2975    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
            2980                2985                2990        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        2995                3000                3005            

Thr Ser Ala Ser Gly Ser Ala Ser Thr Ser Thr Ser Ala Ser Ala Ser 
    3010                3015                3020                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
3025                3030                3035                3040

Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
                3045                3050                3055    

Thr Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
            3060                3065                3070        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        3075                3080                3085            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser 
    3090                3095                3100                

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
3105                3110                3115                3120

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                3125                3130                3135    

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser Ala Ser Thr Ser 
            3140                3145                3150        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        3155                3160                3165            

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
    3170                3175                3180                

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
3185                3190                3195                3200

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                3205                3210                3215    

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            3220                3225                3230        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        3235                3240                3245            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser 
    3250                3255                3260                

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
3265                3270                3275                3280

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
                3285                3290                3295    

Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            3300                3305                3310        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        3315                3320                3325            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
    3330                3335                3340                

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
3345                3350                3355                3360

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser 
                3365                3370                3375    

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
            3380                3385                3390        

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
        3395                3400                3405            

Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser 
    3410                3415                3420                

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
3425                3430                3435                3440

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                3445                3450                3455    

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            3460                3465                3470        

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        3475                3480                3485            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    3490                3495                3500                

Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
3505                3510                3515                3520

Ala Ser Ala Ser Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser 
                3525                3530                3535    

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
            3540                3545                3550        

Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser 
        3555                3560                3565            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser 
    3570                3575                3580                

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
3585                3590                3595                3600

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
                3605                3610                3615    

Glu Ser Ala Ser Thr Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser 
            3620                3625                3630        

Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
        3635                3640                3645            

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser 
    3650                3655                3660                

Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
3665                3670                3675                3680

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                3685                3690                3695    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            3700                3705                3710        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        3715                3720                3725            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    3730                3735                3740                

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
3745                3750                3755                3760

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                3765                3770                3775    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser 
            3780                3785                3790        

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        3795                3800                3805            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
    3810                3815                3820                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
3825                3830                3835                3840

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                3845                3850                3855    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            3860                3865                3870        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        3875                3880                3885            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    3890                3895                3900                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
3905                3910                3915                3920

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                3925                3930                3935    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
            3940                3945                3950        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        3955                3960                3965            

Ala Ser Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    3970                3975                3980                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
3985                3990                3995                4000

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                4005                4010                4015    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            4020                4025                4030        

Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        4035                4040                4045            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    4050                4055                4060                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
4065                4070                4075                4080

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
                4085                4090                4095    

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
            4100                4105                4110        

Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        4115                4120                4125            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser 
    4130                4135                4140                

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
4145                4150                4155                4160

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
                4165                4170                4175    

Ala Ser Thr Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser 
            4180                4185                4190        

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
        4195                4200                4205            

Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser 
    4210                4215                4220                

Ala Ser Thr Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
4225                4230                4235                4240

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4245                4250                4255    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            4260                4265                4270        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4275                4280                4285            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4290                4295                4300                

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
4305                4310                4315                4320

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4325                4330                4335    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Val Ser Ala Ser 
            4340                4345                4350        

Thr Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4355                4360                4365            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
    4370                4375                4380                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Glu Ser Ala Ser 
4385                4390                4395                4400

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4405                4410                4415    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            4420                4425                4430        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4435                4440                4445            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4450                4455                4460                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
4465                4470                4475                4480

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4485                4490                4495    

Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser 
            4500                4505                4510        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4515                4520                4525            

Thr Ser Ala Ser Val Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4530                4535                4540                

Thr Ser Ala Ser Ala Ser Ala Ser Ile Ser Ala Ser Glu Ser Ala Ser 
4545                4550                4555                4560

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4565                4570                4575    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            4580                4585                4590        

Ile Ser Ala Ser Glu Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4595                4600                4605            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4610                4615                4620                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
4625                4630                4635                4640

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
                4645                4650                4655    

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
            4660                4665                4670        

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
        4675                4680                4685            

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Ala Ser Ala Ser Ala Ser 
    4690                4695                4700                

Thr Ser Ala Ser Ala Ser Ala Ser Thr Ser Val Ser Asn Ser Ala Asn 
4705                4710                4715                4720

His Ser Asn Ser Gln Val Gly Asn Thr Ser Gly Ser Thr Gly Lys Ser 
                4725                4730                4735    

Gln Lys Glu Leu Pro Asn Thr Gly Thr Glu Ser Ser Ile Gly Ser Val 
            4740                4745                4750        

Leu Leu Gly Val Leu Ala Ala Val Thr Gly Ile Gly Leu Val Ala Lys 
        4755                4760                4765            

Arg Arg Lys Arg Asp Glu Glu Glu 
    4770                4775    

<210>   3663
<211>   459
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3663
gtgggaaaag aaagacgtaa acaagggaac ttagagcgga aaaagcgagt cgtcaaaaag   60
cgtaagatcc ctttagaaga attgaaagcc tttgtagagg ctcatccaga cgctttttta   120
cgggaaattg cggcccgttt tgattgtgct ttgccctccg tatgggcagt tttaaagcag   180
attaaggtca ttttaaaaaa gacgaccagt tttagggaac aaaagcctga gaaagtttct   240
gagtttcttg atattttgga taacctaaaa gatttaccag tcctatatat tgacgaaacg   300
ggaatcgacc gctacctcta tcgtccttat gcaggggctc ctagagggga gaaagtctat   360
ggcaagatta gcggacggcg ttttgagcgg actaatgagg tggagcaaaa actcaatggt   420
agttttctaa tcagatatat tgattcacaa attagagaa                          459

<210>   3664
<211>   153
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1/Orf2 degenerate

<400>   3664
Met Gly Lys Glu Arg Arg Lys Gln Gly Asn Leu Glu Arg Lys Lys Arg 
1               5                   10                  15      

Val Val Lys Lys Arg Lys Ile Pro Leu Glu Glu Leu Lys Ala Phe Val 
            20                  25                  30          

Glu Ala His Pro Asp Ala Phe Leu Arg Glu Ile Ala Ala Arg Phe Asp 
        35                  40                  45              

Cys Ala Leu Pro Ser Val Trp Ala Val Leu Lys Gln Ile Lys Val Ile 
    50                  55                  60                  

Leu Lys Lys Thr Thr Ser Phe Arg Glu Gln Lys Pro Glu Lys Val Ser 
65                  70                  75                  80  

Glu Phe Leu Asp Ile Leu Asp Asn Leu Lys Asp Leu Pro Val Leu Tyr 
                85                  90                  95      

Ile Asp Glu Thr Gly Ile Asp Arg Tyr Leu Tyr Arg Pro Tyr Ala Gly 
            100                 105                 110         

Ala Pro Arg Gly Glu Lys Val Tyr Gly Lys Ile Ser Gly Arg Arg Phe 
        115                 120                 125             

Glu Arg Thr Asn Glu Val Glu Gln Lys Leu Asn Gly Ser Phe Leu Ile 
    130                 135                 140                 

Arg Tyr Ile Asp Ser Gln Ile Arg Glu 
145                 150             

<210>   3665
<211>   459
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3665
atgcgcaatc atcttgtgac gcagagactg cccgttaatg gactttcttc tatttatgac   60
tctaaaaaga aaggagacac tatgacctat ttggaaaaat ggtttgactt caatcggcgt   120
cagaaagaaa ttgaaagtct cttggaagag accattgccc aacagagcga gcaaagtctg   180
accttgaaag agttctacct gctctactat ctggacttgg ctgaagaaaa atctctacgc   240
cagattgacc tgccagataa gcttcatctg agcccgagcg cagtttctag gatggtggct   300
cgcttggaag ctaaaaattg cggtctactc agtcgcatgt gttgccatca agatagacgc   360
tctagtttta tctgcctgac aaatgatggg caaaagacac tggcctcgct acaaaagact   420
gtcgaagaaa gcttggaagc aggtttggat ttcttgatt                          459

<210>   3666
<211>   153
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903642 (4.E-74)

<400>   3666
Met Arg Asn His Leu Val Thr Gln Arg Leu Pro Val Asn Gly Leu Ser 
1               5                   10                  15      

Ser Ile Tyr Asp Ser Lys Lys Lys Gly Asp Thr Met Thr Tyr Leu Glu 
            20                  25                  30          

Lys Trp Phe Asp Phe Asn Arg Arg Gln Lys Glu Ile Glu Ser Leu Leu 
        35                  40                  45              

Glu Glu Thr Ile Ala Gln Gln Ser Glu Gln Ser Leu Thr Leu Lys Glu 
    50                  55                  60                  

Phe Tyr Leu Leu Tyr Tyr Leu Asp Leu Ala Glu Glu Lys Ser Leu Arg 
65                  70                  75                  80  

Gln Ile Asp Leu Pro Asp Lys Leu His Leu Ser Pro Ser Ala Val Ser 
                85                  90                  95      

Arg Met Val Ala Arg Leu Glu Ala Lys Asn Cys Gly Leu Leu Ser Arg 
            100                 105                 110         

Met Cys Cys His Gln Asp Arg Arg Ser Ser Phe Ile Cys Leu Thr Asn 
        115                 120                 125             

Asp Gly Gln Lys Thr Leu Ala Ser Leu Gln Lys Thr Val Glu Glu Ser 
    130                 135                 140                 

Leu Glu Ala Gly Leu Asp Phe Leu Ile 
145                 150             

<210>   3667
<211>   300
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3667
ttgcgtgcgc aatcattttt cttgacattc tcttttataa ggagtaaaat aaagttagca   60
ttaaacaaag gagttttaaa catgattgaa attacctata tagatgccag caagaacgaa   120
agaactgtga ctttcgagtc ttatgaagac tttgaacgtt cgcaacaagc ttgccttatc   180
ggcgtcgcag actactaccc tgtccaaaaa ttaacttaca agggtcataa tttggactac   240
catgggactt atggagatat cttcttctat ctcatgaaac aagatttaag ccaatataac   300

<210>   3668
<211>   100
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903643 (4.E-55)

<400>   3668
Met Arg Ala Gln Ser Phe Phe Leu Thr Phe Ser Phe Ile Arg Ser Lys 
1               5                   10                  15      

Ile Lys Leu Ala Leu Asn Lys Gly Val Leu Asn Met Ile Glu Ile Thr 
            20                  25                  30          

Tyr Ile Asp Ala Ser Lys Asn Glu Arg Thr Val Thr Phe Glu Ser Tyr 
        35                  40                  45              

Glu Asp Phe Glu Arg Ser Gln Gln Ala Cys Leu Ile Gly Val Ala Asp 
    50                  55                  60                  

Tyr Tyr Pro Val Gln Lys Leu Thr Tyr Lys Gly His Asn Leu Asp Tyr 
65                  70                  75                  80  

His Gly Thr Tyr Gly Asp Ile Phe Phe Tyr Leu Met Lys Gln Asp Leu 
                85                  90                  95      

Ser Gln Tyr Asn 
            100 

<210>   3669
<211>   312
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3669
atggcaaaag caattacaga tgcaacattc gaacaagaaa caaaagacgg tttggtctta   60
gtagacttct gggcaacttg gtgtggtcca tgtcgtatgc aaggtccaat cttggacaaa   120
ttgtctgaag aactttcaga agatgtcttg aaaatcgtta aaatggacgt tgatgaaaat   180
ccaaacacag ctcgtgcttt tggaatcatg tctattccaa ctcttctctt caaaaaagac   240
ggccaagttg tcaaacaagt tgcaggtgtt cacacagcag aacaaatcaa ggccatcatt   300
gctgaattga gc                                                       312

<210>   3670
<211>   104
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thioredoxin (trx)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903644 (1.E-55)

<400>   3670
Met Ala Lys Ala Ile Thr Asp Ala Thr Phe Glu Gln Glu Thr Lys Asp 
1               5                   10                  15      

Gly Leu Val Leu Val Asp Phe Trp Ala Thr Trp Cys Gly Pro Cys Arg 
            20                  25                  30          

Met Gln Gly Pro Ile Leu Asp Lys Leu Ser Glu Glu Leu Ser Glu Asp 
        35                  40                  45              

Val Leu Lys Ile Val Lys Met Asp Val Asp Glu Asn Pro Asn Thr Ala 
    50                  55                  60                  

Arg Ala Phe Gly Ile Met Ser Ile Pro Thr Leu Leu Phe Lys Lys Asp 
65                  70                  75                  80  

Gly Gln Val Val Lys Gln Val Ala Gly Val His Thr Ala Glu Gln Ile 
                85                  90                  95      

Lys Ala Ile Ile Ala Glu Leu Ser 
            100                 

<210>   3671
<211>   462
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3671
atgcaacact atgaaacagt cgaagctgtc acctttgcct acggccaacg tcatcacctc   60
gaaattcaaa ttactagaga aatcgctaag gaacagggca ttcgtcacca tatcctcgat   120
atgtctctgc tgggacaaat cactgctcag ccagactttg cgacgattca tatttcctac   180
attcctgaca agctctgtgt cgagtcaaaa tccctcaaac tatatctatt tagctaccga   240
aaccacggag atttccacga aaactgtatc aacaccatcg ggaaagactt ggtcaacttg   300
ctagaccctc gctatttaga agtctgggga aaattcactc cgcgcggtgg catttcaatc   360
gacccctact acaactacgg taagcaagga actaagtatg agggcttggc agaacaacgc   420
ctcttccaac acgaccttta tccagagaaa attgacaacc gc                      462

<210>   3672
<211>   154
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903645 (4.E-90)

<400>   3672
Met Gln His Tyr Glu Thr Val Glu Ala Val Thr Phe Ala Tyr Gly Gln 
1               5                   10                  15      

Arg His His Leu Glu Ile Gln Ile Thr Arg Glu Ile Ala Lys Glu Gln 
            20                  25                  30          

Gly Ile Arg His His Ile Leu Asp Met Ser Leu Leu Gly Gln Ile Thr 
        35                  40                  45              

Ala Gln Pro Asp Phe Ala Thr Ile His Ile Ser Tyr Ile Pro Asp Lys 
    50                  55                  60                  

Leu Cys Val Glu Ser Lys Ser Leu Lys Leu Tyr Leu Phe Ser Tyr Arg 
65                  70                  75                  80  

Asn His Gly Asp Phe His Glu Asn Cys Ile Asn Thr Ile Gly Lys Asp 
                85                  90                  95      

Leu Val Asn Leu Leu Asp Pro Arg Tyr Leu Glu Val Trp Gly Lys Phe 
            100                 105                 110         

Thr Pro Arg Gly Gly Ile Ser Ile Asp Pro Tyr Tyr Asn Tyr Gly Lys 
        115                 120                 125             

Gln Gly Thr Lys Tyr Glu Gly Leu Ala Glu Gln Arg Leu Phe Gln His 
    130                 135                 140                 

Asp Leu Tyr Pro Glu Lys Ile Asp Asn Arg 
145                 150                 

<210>   3673
<211>   420
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3673
atgaaaatca aagagcaaac taggaagtta gccgcaggtt gctcaaagca ctgttttgag   60
gttgtggata gaactgacga agtcagatca aaacactgtt ttgaggttgt ggatagaact   120
gacgaagtca gatcaaaaca ctgttttgag gttgtggata gaactgacga agtcagctta   180
aaacactgtt ttgaggttgc agatagaact gacgaagtca gcttaaaaca ctgttttgag   240
gttgcagata gaactgacga agtcagctta aaacactgtt ttgaggttgc agatagaact   300
gacgaagtca gcttaaaaca ctgttttgag gttgcagata gaactgacga agtcagatca   360
aaacactgtt ttgaggttgt ggatagaact gacgaagtca gtaaccatac tacggcaaga   420

<210>   3674
<211>   140
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3674
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Arg Ser Lys His 
            20                  25                  30          

Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Arg Ser Lys His Cys 
        35                  40                  45              

Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Leu Lys His Cys Phe 
    50                  55                  60                  

Glu Val Ala Asp Arg Thr Asp Glu Val Ser Leu Lys His Cys Phe Glu 
65                  70                  75                  80  


Val Ala Asp Arg Thr Asp Glu Val Ser Leu Lys His Cys Phe Glu Val 
                85                  90                  95      

Ala Asp Arg Thr Asp Glu Val Ser Leu Lys His Cys Phe Glu Val Ala 
            100                 105                 110         

Asp Arg Thr Asp Glu Val Arg Ser Lys His Cys Phe Glu Val Val Asp 
        115                 120                 125             

Arg Thr Asp Glu Val Ser Asn His Thr Thr Ala Arg 
    130                 135                 140 

<210>   3675
<211>   666
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3675
atgaaaaaat ttgttgctga gttaatcggt acgttcatgt ttgtattcgt cgggacagga   60
gctgttgttt ttggaaatgg tcttgatggc cttggtcacc ttggaatcgc ctttgccttt   120
ggtttggcaa tcgtggtggc agcctactca atcggaactg tttcaggtgc tcacttgaac   180
ccggctgttt cgattgctat gtttgtaaac aaacgtttgt catcttcaga acttgtaaac   240
tacatccttg gtcaggttgt tggagctttc atcgcttctg gcgctgtctt cttcctcttg   300
gctaactcag gtatgtcaac tgctagtctt ggtgaaaatg ccttggcaaa cggtgtcact   360
gtctttggtg gtttcttgtt tgaagtcatc gcaactttct tgtttgtatt ggttatcatg   420
actgtgactt cagaaagcaa gggcaatggc gcgattgctg gtttggtaat cggtttgtca   480
ttgatggcga tgattcttgt cggattgaag attactggac tttcagtaaa cccagctcgt   540
agcttggcac cagctgtctt ggtaggcggc gcagcccttc aacaagtttg gattttcatc   600
cttgcaccaa tcgctggtgg agttcttgca gcccttgttg caaaaaattt ccttggaaca   660
gaagaa                                                              666

<210>   3676
<211>   222
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aquaporin
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903646 (e-118)

<400>   3676
Met Lys Lys Phe Val Ala Glu Leu Ile Gly Thr Phe Met Phe Val Phe 
1               5                   10                  15      

Val Gly Thr Gly Ala Val Val Phe Gly Asn Gly Leu Asp Gly Leu Gly 
            20                  25                  30          

His Leu Gly Ile Ala Phe Ala Phe Gly Leu Ala Ile Val Val Ala Ala 
        35                  40                  45              

Tyr Ser Ile Gly Thr Val Ser Gly Ala His Leu Asn Pro Ala Val Ser 
    50                  55                  60                  

Ile Ala Met Phe Val Asn Lys Arg Leu Ser Ser Ser Glu Leu Val Asn 
65                  70                  75                  80  

Tyr Ile Leu Gly Gln Val Val Gly Ala Phe Ile Ala Ser Gly Ala Val 
                85                  90                  95      

Phe Phe Leu Leu Ala Asn Ser Gly Met Ser Thr Ala Ser Leu Gly Glu 
            100                 105                 110         

Asn Ala Leu Ala Asn Gly Val Thr Val Phe Gly Gly Phe Leu Phe Glu 
        115                 120                 125             

Val Ile Ala Thr Phe Leu Phe Val Leu Val Ile Met Thr Val Thr Ser 
    130                 135                 140                 

Glu Ser Lys Gly Asn Gly Ala Ile Ala Gly Leu Val Ile Gly Leu Ser 
145                 150                 155                 160 

Leu Met Ala Met Ile Leu Val Gly Leu Lys Ile Thr Gly Leu Ser Val 
                165                 170                 175     

Asn Pro Ala Arg Ser Leu Ala Pro Ala Val Leu Val Gly Gly Ala Ala 
            180                 185                 190         

Leu Gln Gln Val Trp Ile Phe Ile Leu Ala Pro Ile Ala Gly Gly Val 
        195                 200                 205             

Leu Ala Ala Leu Val Ala Lys Asn Phe Leu Gly Thr Glu Glu 
    210                 215                 220         

<210>   3677
<211>   558
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3677
ttgaccatgt atcaagattt actaagaaaa atagcagaag aaaaaccaaa ttataaccag   60
gaagaaatcc agtggttgtt tgatcatttg ggaaatcctt ctccagaaat tcgtaatgtc   120
cttttaaatc aaggcttgca ctatctttca aaagaaaagg atacaagggg tttctcaagt   180
cagtatggtt gggttcacgc ttttgcacat ggagccgatt tactgacaga ggtggtttgt   240
catccagact ttcctaaaaa cagagttcat gaagtatttg atatacttgg ccaactattt   300
aaaagaatgt cgattcgctt tacagatgat gaggattggc gtttagcaag agtgatctat   360
gaacctattt tacaagggaa gttggagcaa gaacaagtag cttcttggat aaaaactgtt   420
gattttccga tagaagaaag ggaggatttt tacaaatttt ccaactttag atcctgtctg   480
gtggaagtct atgtccaact tgaccagaga aatagtttac aagatgacct gaaagaagct   540
atccagtctt ttcaatac                                                 558

<210>   3678
<211>   186
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903647 (e-108)

<400>   3678
Met Thr Met Tyr Gln Asp Leu Leu Arg Lys Ile Ala Glu Glu Lys Pro 
1               5                   10                  15      

Asn Tyr Asn Gln Glu Glu Ile Gln Trp Leu Phe Asp His Leu Gly Asn 
            20                  25                  30          

Pro Ser Pro Glu Ile Arg Asn Val Leu Leu Asn Gln Gly Leu His Tyr 
        35                  40                  45              

Leu Ser Lys Glu Lys Asp Thr Arg Gly Phe Ser Ser Gln Tyr Gly Trp 
    50                  55                  60                  

Val His Ala Phe Ala His Gly Ala Asp Leu Leu Thr Glu Val Val Cys 
65                  70                  75                  80  

His Pro Asp Phe Pro Lys Asn Arg Val His Glu Val Phe Asp Ile Leu 
                85                  90                  95      

Gly Gln Leu Phe Lys Arg Met Ser Ile Arg Phe Thr Asp Asp Glu Asp 
            100                 105                 110         

Trp Arg Leu Ala Arg Val Ile Tyr Glu Pro Ile Leu Gln Gly Lys Leu 
        115                 120                 125             

Glu Gln Glu Gln Val Ala Ser Trp Ile Lys Thr Val Asp Phe Pro Ile 
    130                 135                 140                 

Glu Glu Arg Glu Asp Phe Tyr Lys Phe Ser Asn Phe Arg Ser Cys Leu 
145                 150                 155                 160 

Val Glu Val Tyr Val Gln Leu Asp Gln Arg Asn Ser Leu Gln Asp Asp 
                165                 170                 175     

Leu Lys Glu Ala Ile Gln Ser Phe Gln Tyr 
            180                 185     

<210>   3679
<211>   1794
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3679
atggaacaaa aacaccgttc agaatttcca gagaaggaac tctgggactt aacagcccta   60
taccaagacc gtgaggattt cttgcgtgca atcgagaaag ctcgcgaaga catcaaccag   120
tttagccgtg attacaaggg caatcttcac acttttgagg atttcgagaa ggcctttgcg   180
gaattggaac agatctacat tcagatgagc catattggca actatggttt tatgcctcag   240
acgacggact atagcaatga cgaatttgcc aatattgccc aagctgggat ggaatttgaa   300
acagatgcca gcgtagcctt gaccttcttt gacgatgcct tggtggcagc agatgaggaa   360
gtcttggacc gtttgggtaa attgccacat ttaacagctg ccattcgtca ggctaaaatc   420
aaaaaagccc actacttagg ggcagatgtg gagaaggcct tgacaaatct cggtgaagtt   480
ttctacagtc cgcaggacat ttatactaag atgcgagctg gggattttga aatggctgac   540
tttgaagccc atggcaagac ctacaaaaac agctttgtga cctatgagaa tttctaccaa   600
aaccatgagg atgctgaggt tcgtgagaaa tccttccgtt ccttctcaga gggacttcgt   660
aagcaccaaa atacggctgc agcagcctat ctggctcagg tcaagtctga aaaactcttg   720
gctgatatga agggatacga ctctgtcttt gactatcttc tagctgaaca agaagtggac   780
cgtgtcatgt ttgaccgcca gattgacctc atcatgaagg actttgcacc agtcgctcag   840
agatacctca agcatgttgc caaggtaaat ggtcttgaaa agatgacctt tgcagactgg   900
aaattggact tggacagcgc cctgaatcct gaagtgacta ttgacgatgc ctatgatttg   960
gtcatgaagt cggtagaacc tttggggcaa gaatattgtc aggaagttgc tcgttaccaa   1020
gaagagcgct gggtggactt tgctgctaac agtggcaagg attccggtgg ttatgcggcg   1080
gacccatatc gcgtacaccc ttatgtactc atgagctgga caggccgttt gagcgatgtc   1140
tataccttga ttcatgaaat cgggcattct ggtcaattca tcttttcaga caatcatcaa   1200
agttacttca atgcccatat gtcgacctac tatgttgaag caccgtcaac cttcaatgaa   1260
ttgctactca gtgattactt ggagaaccag tctaatgacc cacgtcaaaa acgcttcgct   1320
ctggctcatc gcttgacaga cacctacttc cataacttta tcacccacct cttggaagcc   1380
gccttccagc gtaaggtgta tacattgatt gaagaagggg agacctttgg agcaagcaag   1440
ctcaacagca ttatgaagga agttttgacg gatttctggg gagatgctat tgaaattgac   1500
gatgatgcaa ctctgacttg gatgcgccaa gctcactact atatgggctt gtatagttac   1560
acttactcag caggactagt tatctcgact gctggttacc ttcatctaaa acattctgaa   1620
actggagctg aagactggct caatctcctc aaatcaggtg gtagcaagac accacttgag   1680
tcagccatga ttatcggtgc tgatatttca acagacaaac cactccgtga taccatccaa   1740
ttcttgtctg acacagttga ccagattatc tcctatagtg ctgagttggg agag         1794

<210>   3680
<211>   598
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligoendopeptidase F, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903648 (0.E+01)

<400>   3680
Met Glu Gln Lys His Arg Ser Glu Phe Pro Glu Lys Glu Leu Trp Asp 
1               5                   10                  15      

Leu Thr Ala Leu Tyr Gln Asp Arg Glu Asp Phe Leu Arg Ala Ile Glu 
            20                  25                  30          

Lys Ala Arg Glu Asp Ile Asn Gln Phe Ser Arg Asp Tyr Lys Gly Asn 
        35                  40                  45              

Leu His Thr Phe Glu Asp Phe Glu Lys Ala Phe Ala Glu Leu Glu Gln 
    50                  55                  60                  

Ile Tyr Ile Gln Met Ser His Ile Gly Asn Tyr Gly Phe Met Pro Gln 
65                  70                  75                  80  

Thr Thr Asp Tyr Ser Asn Asp Glu Phe Ala Asn Ile Ala Gln Ala Gly 
                85                  90                  95      

Met Glu Phe Glu Thr Asp Ala Ser Val Ala Leu Thr Phe Phe Asp Asp 
            100                 105                 110         

Ala Leu Val Ala Ala Asp Glu Glu Val Leu Asp Arg Leu Gly Lys Leu 
        115                 120                 125             

Pro His Leu Thr Ala Ala Ile Arg Gln Ala Lys Ile Lys Lys Ala His 
    130                 135                 140                 

Tyr Leu Gly Ala Asp Val Glu Lys Ala Leu Thr Asn Leu Gly Glu Val 
145                 150                 155                 160 

Phe Tyr Ser Pro Gln Asp Ile Tyr Thr Lys Met Arg Ala Gly Asp Phe 
                165                 170                 175     

Glu Met Ala Asp Phe Glu Ala His Gly Lys Thr Tyr Lys Asn Ser Phe 
            180                 185                 190         

Val Thr Tyr Glu Asn Phe Tyr Gln Asn His Glu Asp Ala Glu Val Arg 
        195                 200                 205             

Glu Lys Ser Phe Arg Ser Phe Ser Glu Gly Leu Arg Lys His Gln Asn 
    210                 215                 220                 

Thr Ala Ala Ala Ala Tyr Leu Ala Gln Val Lys Ser Glu Lys Leu Leu 
225                 230                 235                 240 

Ala Asp Met Lys Gly Tyr Asp Ser Val Phe Asp Tyr Leu Leu Ala Glu 
                245                 250                 255     

Gln Glu Val Asp Arg Val Met Phe Asp Arg Gln Ile Asp Leu Ile Met 
            260                 265                 270         

Lys Asp Phe Ala Pro Val Ala Gln Arg Tyr Leu Lys His Val Ala Lys 
        275                 280                 285             

Val Asn Gly Leu Glu Lys Met Thr Phe Ala Asp Trp Lys Leu Asp Leu 
    290                 295                 300                 

Asp Ser Ala Leu Asn Pro Glu Val Thr Ile Asp Asp Ala Tyr Asp Leu 

305                 310                 315                 320 

Val Met Lys Ser Val Glu Pro Leu Gly Gln Glu Tyr Cys Gln Glu Val 
                325                 330                 335     

Ala Arg Tyr Gln Glu Glu Arg Trp Val Asp Phe Ala Ala Asn Ser Gly 
            340                 345                 350         

Lys Asp Ser Gly Gly Tyr Ala Ala Asp Pro Tyr Arg Val His Pro Tyr 
        355                 360                 365             

Val Leu Met Ser Trp Thr Gly Arg Leu Ser Asp Val Tyr Thr Leu Ile 
    370                 375                 380                 

His Glu Ile Gly His Ser Gly Gln Phe Ile Phe Ser Asp Asn His Gln 
385                 390                 395                 400 

Ser Tyr Phe Asn Ala His Met Ser Thr Tyr Tyr Val Glu Ala Pro Ser 
                405                 410                 415     

Thr Phe Asn Glu Leu Leu Leu Ser Asp Tyr Leu Glu Asn Gln Ser Asn 
            420                 425                 430         

Asp Pro Arg Gln Lys Arg Phe Ala Leu Ala His Arg Leu Thr Asp Thr 
        435                 440                 445             

Tyr Phe His Asn Phe Ile Thr His Leu Leu Glu Ala Ala Phe Gln Arg 
    450                 455                 460                 

Lys Val Tyr Thr Leu Ile Glu Glu Gly Glu Thr Phe Gly Ala Ser Lys 
465                 470                 475                 480 

Leu Asn Ser Ile Met Lys Glu Val Leu Thr Asp Phe Trp Gly Asp Ala 
                485                 490                 495     

Ile Glu Ile Asp Asp Asp Ala Thr Leu Thr Trp Met Arg Gln Ala His 
            500                 505                 510         

Tyr Tyr Met Gly Leu Tyr Ser Tyr Thr Tyr Ser Ala Gly Leu Val Ile 
        515                 520                 525             

Ser Thr Ala Gly Tyr Leu His Leu Lys His Ser Glu Thr Gly Ala Glu 
    530                 535                 540                 

Asp Trp Leu Asn Leu Leu Lys Ser Gly Gly Ser Lys Thr Pro Leu Glu 
545                 550                 555                 560 

Ser Ala Met Ile Ile Gly Ala Asp Ile Ser Thr Asp Lys Pro Leu Arg 
                565                 570                 575     

Asp Thr Ile Gln Phe Leu Ser Asp Thr Val Asp Gln Ile Ile Ser Tyr 
            580                 585                 590         

Ser Ala Glu Leu Gly Glu 
        595             

<210>   3681
<211>   741
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3681
atgcagcagt attttgtaaa aggcagtgct atctctcctg tcactatcga ggacaaggaa   60
accagtaagc atatgtttca ggttatgcgc ttgaaagaag aggatgaggt taccttagtc   120
tttgatgatg gcatcaagcg cttggcgcgc gtgctggata tggaaaatcg tcagtttgag   180
ttggtccaag aattaaatga caatgtggaa ctaccagtcc aagtgaccat cgcatctgga   240
tttcccaagg gagacaagct ggagttcatc gctcaaaaag taaccgaact gggggctagc   300
caaatctggg cctttcctgc agactggtca gttgccaagt gggatggcaa gaaattgggt   360
aaaaaagttg aaaaactaga aaaaattgcc cttggagcag ccgagcaaag caagcgtaat   420
attgtaccaa gtattaaact tttcgagaaa aaagcagatt ttctagctca gctggaccag   480
tttgactcta tcatagtagc ctatgaagaa tcagctaaag aaggagaagc cgctgcgctt   540
ctgcaagcag tcactggtct tgaaacagga gccaaactgc tctttatctt tggtccagaa   600
ggcggtctct cacctgcaga aatcgaaagt tttgaagcta aaggagccgt tttggcaggc   660
ctaggtcctc gtattttgcg agcagaaaca gcaccgcttt acgctttatc agcccttagt   720
gttttagtag aattagagaa a                                             741

<210>   3682
<211>   247
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903649 (e-136)

<400>   3682
Met Gln Gln Tyr Phe Val Lys Gly Ser Ala Ile Ser Pro Val Thr Ile 
1               5                   10                  15      

Glu Asp Lys Glu Thr Ser Lys His Met Phe Gln Val Met Arg Leu Lys 
            20                  25                  30          

Glu Glu Asp Glu Val Thr Leu Val Phe Asp Asp Gly Ile Lys Arg Leu 
        35                  40                  45              

Ala Arg Val Leu Asp Met Glu Asn Arg Gln Phe Glu Leu Val Gln Glu 
    50                  55                  60                  

Leu Asn Asp Asn Val Glu Leu Pro Val Gln Val Thr Ile Ala Ser Gly 
65                  70                  75                  80  

Phe Pro Lys Gly Asp Lys Leu Glu Phe Ile Ala Gln Lys Val Thr Glu 
                85                  90                  95      

Leu Gly Ala Ser Gln Ile Trp Ala Phe Pro Ala Asp Trp Ser Val Ala 
            100                 105                 110         

Lys Trp Asp Gly Lys Lys Leu Gly Lys Lys Val Glu Lys Leu Glu Lys 
        115                 120                 125             

Ile Ala Leu Gly Ala Ala Glu Gln Ser Lys Arg Asn Ile Val Pro Ser 
    130                 135                 140                 

Ile Lys Leu Phe Glu Lys Lys Ala Asp Phe Leu Ala Gln Leu Asp Gln 
145                 150                 155                 160 

Phe Asp Ser Ile Ile Val Ala Tyr Glu Glu Ser Ala Lys Glu Gly Glu 
                165                 170                 175     

Ala Ala Ala Leu Leu Gln Ala Val Thr Gly Leu Glu Thr Gly Ala Lys 
            180                 185                 190         

Leu Leu Phe Ile Phe Gly Pro Glu Gly Gly Leu Ser Pro Ala Glu Ile 
        195                 200                 205             

Glu Ser Phe Glu Ala Lys Gly Ala Val Leu Ala Gly Leu Gly Pro Arg 
    210                 215                 220                 

Ile Leu Arg Ala Glu Thr Ala Pro Leu Tyr Ala Leu Ser Ala Leu Ser 
225                 230                 235                 240 

Val Leu Val Glu Leu Glu Lys 
                245         

<210>   3683
<211>   981
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3683
ttggttttgt gttttacggg cttggtatta ataatggaaa catggcaaga gttaaaagtt   60
acagtgaagc gtgagggaga ggagttggtt tccaatctct tgattgagct gggagcgcaa   120
ggagtcgcaa tcgaagacag tatggactat gtgggaaatg tggaccgctt tggagagatt   180
ttcccagagg tggagcagca agaagaaatc gtagtgacag cctactaccc tgacacggtg   240
gatgtgacag tggttgaggc ggatttgcag gctcgtctag cagaattgac agattttatg   300
gatttgggag agttaaaaat aggtacgact gccttggctg aggaagactg ggcagacaac   360
tggaagaaat actatgaacc tgctcgtatc actcatgatt tgaccatcgt tccctcttgg   420
acagactatg aggcgactgc gggggaaatg attatcaagc tggatcctgg catggctttt   480
ggtactggaa cccacccaac taccaagatg agcctttttg ccttggaaca ggttcttcgt   540
ggtggcgaaa cggtgctaga tgtggggact ggttcagggg ttctctctat tgccagctcg   600
cttctggggg ctaaagaaat tttcgcctat gacctggatg atgtggcggt tcgtgtggct   660
caggaaaata ttgagctcaa ccctggcatg gaaaatatcc atgtagcggc tggagatttg   720
cttaagggtg tggaaattga ggcagatgtg attgtggcta atatcttggc ggatatcctc   780
attcatctaa tagacgatgc ttatcgcttg gtaaaggatg aaggctacct gatcatgagt   840
ggcattatca aggacaagtt ggacatggtg cgccagtcgg ctgagtcagc tggatttttc   900
ctcgaaactc acatggttca aggggaatgg aatacctgtg tctttaagaa aaccaaggat   960
atctctggtg tgattggagg c                                             981

<210>   3684
<211>   327
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L11 methyltransferase (prmA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903650 (e-176)

<400>   3684
Met Val Leu Cys Phe Thr Gly Leu Val Leu Ile Met Glu Thr Trp Gln 
1               5                   10                  15      

Glu Leu Lys Val Thr Val Lys Arg Glu Gly Glu Glu Leu Val Ser Asn 
            20                  25                  30          

Leu Leu Ile Glu Leu Gly Ala Gln Gly Val Ala Ile Glu Asp Ser Met 
        35                  40                  45              

Asp Tyr Val Gly Asn Val Asp Arg Phe Gly Glu Ile Phe Pro Glu Val 
    50                  55                  60                  

Glu Gln Gln Glu Glu Ile Val Val Thr Ala Tyr Tyr Pro Asp Thr Val 
65                  70                  75                  80  

Asp Val Thr Val Val Glu Ala Asp Leu Gln Ala Arg Leu Ala Glu Leu 
                85                  90                  95      

Thr Asp Phe Met Asp Leu Gly Glu Leu Lys Ile Gly Thr Thr Ala Leu 
            100                 105                 110         

Ala Glu Glu Asp Trp Ala Asp Asn Trp Lys Lys Tyr Tyr Glu Pro Ala 
        115                 120                 125             

Arg Ile Thr His Asp Leu Thr Ile Val Pro Ser Trp Thr Asp Tyr Glu 
    130                 135                 140                 

Ala Thr Ala Gly Glu Met Ile Ile Lys Leu Asp Pro Gly Met Ala Phe 
145                 150                 155                 160 

Gly Thr Gly Thr His Pro Thr Thr Lys Met Ser Leu Phe Ala Leu Glu 
                165                 170                 175     

Gln Val Leu Arg Gly Gly Glu Thr Val Leu Asp Val Gly Thr Gly Ser 
            180                 185                 190         

Gly Val Leu Ser Ile Ala Ser Ser Leu Leu Gly Ala Lys Glu Ile Phe 
        195                 200                 205             

Ala Tyr Asp Leu Asp Asp Val Ala Val Arg Val Ala Gln Glu Asn Ile 
    210                 215                 220                 

Glu Leu Asn Pro Gly Met Glu Asn Ile His Val Ala Ala Gly Asp Leu 
225                 230                 235                 240 

Leu Lys Gly Val Glu Ile Glu Ala Asp Val Ile Val Ala Asn Ile Leu 
                245                 250                 255     

Ala Asp Ile Leu Ile His Leu Ile Asp Asp Ala Tyr Arg Leu Val Lys 
            260                 265                 270         

Asp Glu Gly Tyr Leu Ile Met Ser Gly Ile Ile Lys Asp Lys Leu Asp 
        275                 280                 285             

Met Val Arg Gln Ser Ala Glu Ser Ala Gly Phe Phe Leu Glu Thr His 
    290                 295                 300                 

Met Val Gln Gly Glu Trp Asn Thr Cys Val Phe Lys Lys Thr Lys Asp 
305                 310                 315                 320 

Ile Ser Gly Val Ile Gly Gly 
                325         

<210>   3685
<211>   426
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3685
atggaactag aaatttctga tttcacaggt tgcaagattg ctttgttttg tggggataag   60
cttttgacta tcttacgcga tgataaggca agtattccct gggccaatat gtgggaactg   120
ccaggtggtg gccgtgaagg ggacgaaagc ccttttgaat gcgctcggcg tgaagtttat   180
gaggaactgg gaattcattt agatgaagac tgtctgcttt ggagcaagat ttatcctagc   240
gtaattttta aaggcaagaa atcggtcttt atggttggtc agctaagaca agaacaattt   300
gacaatatca tcttcggaga tgaaggacag ggctatcagc tgatgaatgt tgaggaattt   360
cttagttcca gtcaagttgt gcctcagttg caagagagat taaaagatta tttaaaagta   420
agtgat                                                              426

<210>   3686
<211>   142
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MutT/nudix family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903651 (4.E-73)

<400>   3686
Met Glu Leu Glu Ile Ser Asp Phe Thr Gly Cys Lys Ile Ala Leu Phe 
1               5                   10                  15      

Cys Gly Asp Lys Leu Leu Thr Ile Leu Arg Asp Asp Lys Ala Ser Ile 
            20                  25                  30          

Pro Trp Ala Asn Met Trp Glu Leu Pro Gly Gly Gly Arg Glu Gly Asp 
        35                  40                  45              

Glu Ser Pro Phe Glu Cys Ala Arg Arg Glu Val Tyr Glu Glu Leu Gly 
    50                  55                  60                  

Ile His Leu Asp Glu Asp Cys Leu Leu Trp Ser Lys Ile Tyr Pro Ser 
65                  70                  75                  80  

Val Ile Phe Lys Gly Lys Lys Ser Val Phe Met Val Gly Gln Leu Arg 
                85                  90                  95      

Gln Glu Gln Phe Asp Asn Ile Ile Phe Gly Asp Glu Gly Gln Gly Tyr 
            100                 105                 110         

Gln Leu Met Asn Val Glu Glu Phe Leu Ser Ser Ser Gln Val Val Pro 
        115                 120                 125             

Gln Leu Gln Glu Arg Leu Lys Asp Tyr Leu Lys Val Ser Asp 
    130                 135                 140         

<210>   3687
<211>   1101
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3687
ttggttggag gtgttatgaa gaaaattggg acttatttgg tttatgtgct agctgttgtc   60
tttattatgc tagcttttgc ttgtggaaca atcgcatttg cagagttggg gtattccgca   120
gttttagcct ttacttttgg ttatgccttc gctcttctaa gcatgtattt aatctttatt   180
cttcatgagc tgggtcatgc tttttgtggc tacttgacag gctatcggct ggtggctttt   240
ggattaggac attttatttt gaccaaaaag tcaggcaggt ttcatcttag tagaacagcc   300
attctgaaaa atgttggtgc tcaatacatt ggtttaaaag aggatgaaag cgatcaaaga   360
atcatcctga tgctttcagg aggcttgatg gttcatctcg gcttgatatt attggcgata   420
ttgtttggat ttttgacaag aagctggtat tttgcaggga cttggatttt tcttaattta   480
tctttcttcc taaataacat tttgccagtc gacatcaccg atggagcaaa aatttgggaa   540
ttactacaac accctgaaaa taccaaatac gcctacctgg tattgagaca ttctgcccag   600
accttgctag ctcctcaaga atatgatttg aaagactttg ttcaagcagt tcctgaggat   660
gcacgaggga gttttgcgga tggtgtatta ggtatgcaag gtgaagtttc cattttggaa   720
gggaaggaag aagtagctaa acagcagttt caagcattac ttgagaggac aactactccg   780
atgatgcaga cagttgccca actatccctg cttcatatcg ccttgttgga aggagatttt   840
gagcaagcgg agcaatatgc tagtattcga caggtcaaat cgtttctgtc tctcaaactg   900
tccaatcttc aagtgataca agcctggtat caattaaagg tgaagaaaga tgtagatcga   960
actcgtaagg ctctcaagat tgctagacag aaaatggata gtagtcgaat gttgagggat   1020
gagaaaagat attatgaaaa ctggttagcc gagctggaaa aggaaatgtt agaaggaact   1080
gaagatggaa ctagaaattt c                                             1101

<210>   3688
<211>   367
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903652 (0.E+01)

<400>   3688
Met Val Gly Gly Val Met Lys Lys Ile Gly Thr Tyr Leu Val Tyr Val 
1               5                   10                  15      

Leu Ala Val Val Phe Ile Met Leu Ala Phe Ala Cys Gly Thr Ile Ala 
            20                  25                  30          

Phe Ala Glu Leu Gly Tyr Ser Ala Val Leu Ala Phe Thr Phe Gly Tyr 

        35                  40                  45              

Ala Phe Ala Leu Leu Ser Met Tyr Leu Ile Phe Ile Leu His Glu Leu 
    50                  55                  60                  

Gly His Ala Phe Cys Gly Tyr Leu Thr Gly Tyr Arg Leu Val Ala Phe 
65                  70                  75                  80  

Gly Leu Gly His Phe Ile Leu Thr Lys Lys Ser Gly Arg Phe His Leu 
                85                  90                  95      

Ser Arg Thr Ala Ile Leu Lys Asn Val Gly Ala Gln Tyr Ile Gly Leu 
            100                 105                 110         

Lys Glu Asp Glu Ser Asp Gln Arg Ile Ile Leu Met Leu Ser Gly Gly 
        115                 120                 125             

Leu Met Val His Leu Gly Leu Ile Leu Leu Ala Ile Leu Phe Gly Phe 
    130                 135                 140                 

Leu Thr Arg Ser Trp Tyr Phe Ala Gly Thr Trp Ile Phe Leu Asn Leu 
145                 150                 155                 160 

Ser Phe Phe Leu Asn Asn Ile Leu Pro Val Asp Ile Thr Asp Gly Ala 
                165                 170                 175     

Lys Ile Trp Glu Leu Leu Gln His Pro Glu Asn Thr Lys Tyr Ala Tyr 
            180                 185                 190         

Leu Val Leu Arg His Ser Ala Gln Thr Leu Leu Ala Pro Gln Glu Tyr 
        195                 200                 205             

Asp Leu Lys Asp Phe Val Gln Ala Val Pro Glu Asp Ala Arg Gly Ser 
    210                 215                 220                 

Phe Ala Asp Gly Val Leu Gly Met Gln Gly Glu Val Ser Ile Leu Glu 
225                 230                 235                 240 

Gly Lys Glu Glu Val Ala Lys Gln Gln Phe Gln Ala Leu Leu Glu Arg 
                245                 250                 255     

Thr Thr Thr Pro Met Met Gln Thr Val Ala Gln Leu Ser Leu Leu His 
            260                 265                 270         

Ile Ala Leu Leu Glu Gly Asp Phe Glu Gln Ala Glu Gln Tyr Ala Ser 
        275                 280                 285             

Ile Arg Gln Val Lys Ser Phe Leu Ser Leu Lys Leu Ser Asn Leu Gln 
    290                 295                 300                 

Val Ile Gln Ala Trp Tyr Gln Leu Lys Val Lys Lys Asp Val Asp Arg 
305                 310                 315                 320 

Thr Arg Lys Ala Leu Lys Ile Ala Arg Gln Lys Met Asp Ser Ser Arg 
                325                 330                 335     

Met Leu Arg Asp Glu Lys Arg Tyr Tyr Glu Asn Trp Leu Ala Glu Leu 
            340                 345                 350         

Glu Lys Glu Met Leu Glu Gly Thr Glu Asp Gly Thr Arg Asn Phe 
        355                 360                 365         

<210>   3689
<211>   468
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   3689
atggcaacat acggattttt agatatttta gaggaagagt tggacaagaa ctttcccttt   60
gactttgaga ttagctggga caaacgcaac catgcggtag aagtgagttt tctattggaa   120
gcgcaaaatg ctgcaggtgt ggagatggtg gatgaagacg gagaggtttc atcagatgac   180
attctttttg aggaagcggt ccttttctac aatcctgcca agtcaacagt caatgaggaa   240
gactatttga ctgttattcc ttacctgcct aaaaaaggat tttcccgtga atttttagct   300
tattttgcgc ttttccttaa agatactgct gaggttgggc tagatgtcct catggacttt   360
ttggaagacc cagaagcaga ggaatttgtc atggaatgga accaagaagt ctttgaagaa   420
ggaaaaattg gcttggaaaa gggagaattt tatccttatc caagatac                468

<210>   3690
<211>   156
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903653 (2.E-88)

<400>   3690
Met Ala Thr Tyr Gly Phe Leu Asp Ile Leu Glu Glu Glu Leu Asp Lys 
1               5                   10                  15      

Asn Phe Pro Phe Asp Phe Glu Ile Ser Trp Asp Lys Arg Asn His Ala 
            20                  25                  30          

Val Glu Val Ser Phe Leu Leu Glu Ala Gln Asn Ala Ala Gly Val Glu 
        35                  40                  45              

Met Val Asp Glu Asp Gly Glu Val Ser Ser Asp Asp Ile Leu Phe Glu 
    50                  55                  60                  

Glu Ala Val Leu Phe Tyr Asn Pro Ala Lys Ser Thr Val Asn Glu Glu 
65                  70                  75                  80  

Asp Tyr Leu Thr Val Ile Pro Tyr Leu Pro Lys Lys Gly Phe Ser Arg 
                85                  90                  95      

Glu Phe Leu Ala Tyr Phe Ala Leu Phe Leu Lys Asp Thr Ala Glu Val 
            100                 105                 110         

Gly Leu Asp Val Leu Met Asp Phe Leu Glu Asp Pro Glu Ala Glu Glu 
        115                 120                 125             

Phe Val Met Glu Trp Asn Gln Glu Val Phe Glu Glu Gly Lys Ile Gly 
    130                 135                 140                 

Leu Glu Lys Gly Glu Phe Tyr Pro Tyr Pro Arg Tyr 
145                 150                 155     

<210>   3691
<211>   450
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3691
atgttagtta cgtatccagc tttattttat tatgacgaca cagacggaac agaagcgact   60
tattttgtcc atttcccaga ttttgaatac tcagctacac aaggagaggg gatttctgag   120
gctttggcta tggggtcgga gtggctaggg ataactgttg cagatttgat agagagtgat   180
ggagagttac ctcagccatc agatatcaat agcttgtctt taattgataa tgatcctttt   240
aaagatgatg aagatttcgt gtcaacctat gaccttgata aatcttttat ttctatggta   300
tctgttgatg tatcagaata cctaggaagt caggaaccca ttaaaaagac tttgaccata   360
ccaaaatggg cagataagtt gggacgagaa atggggctta acttttctca gactttgaca   420
gacgctattg cagataagaa agttcaagcc                                    450

<210>   3692
<211>   150
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903654 (2.E-84)

<400>   3692
Met Leu Val Thr Tyr Pro Ala Leu Phe Tyr Tyr Asp Asp Thr Asp Gly 
1               5                   10                  15      

Thr Glu Ala Thr Tyr Phe Val His Phe Pro Asp Phe Glu Tyr Ser Ala 
            20                  25                  30          

Thr Gln Gly Glu Gly Ile Ser Glu Ala Leu Ala Met Gly Ser Glu Trp 
        35                  40                  45              

Leu Gly Ile Thr Val Ala Asp Leu Ile Glu Ser Asp Gly Glu Leu Pro 
    50                  55                  60                  

Gln Pro Ser Asp Ile Asn Ser Leu Ser Leu Ile Asp Asn Asp Pro Phe 
65                  70                  75                  80  

Lys Asp Asp Glu Asp Phe Val Ser Thr Tyr Asp Leu Asp Lys Ser Phe 
                85                  90                  95      

Ile Ser Met Val Ser Val Asp Val Ser Glu Tyr Leu Gly Ser Gln Glu 
            100                 105                 110         

Pro Ile Lys Lys Thr Leu Thr Ile Pro Lys Trp Ala Asp Lys Leu Gly 
        115                 120                 125             

Arg Glu Met Gly Leu Asn Phe Ser Gln Thr Leu Thr Asp Ala Ile Ala 
    130                 135                 140                 

Asp Lys Lys Val Gln Ala 
145                 150 

<210>   3693
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3693
atggtgttgt caggaggtaa aagcgctatg cctatgacac aaaaagagat ggttaaactc   60
cttacggccc atggttggat aaagactaga ggcggtaaag gctcccatat taaaatggaa   120
aagcaagggg aaagacctat cacaatcctt catggtgagc tgaataagta cactgaaaga   180
gggataagaa agcaagctgg gttg                                          204

<210>   3694
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903655 (2.E-35)

<400>   3694
Met Val Leu Ser Gly Gly Lys Ser Ala Met Pro Met Thr Gln Lys Glu 
1               5                   10                  15      

Met Val Lys Leu Leu Thr Ala His Gly Trp Ile Lys Thr Arg Gly Gly 
            20                  25                  30          

Lys Gly Ser His Ile Lys Met Glu Lys Gln Gly Glu Arg Pro Ile Thr 
        35                  40                  45              

Ile Leu His Gly Glu Leu Asn Lys Tyr Thr Glu Arg Gly Ile Arg Lys 
    50                  55                  60                  

Gln Ala Gly Leu 
65              

<210>   3695
<211>   177
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3695
ttgaatttga ttttcgaaga gtatcagttt gtaaaaattg gagataaaaa atatagagta   60
cgcagtgttc ctatgattca ttcaactccg cctcaatctg tcttagatcg agatactttt   120
acaattgact atacagatga tgaattgctc gataaagaag cagtttttac tactcat      177

<210>   3696
<211>   59
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3696
Met Asn Leu Ile Phe Glu Glu Tyr Gln Phe Val Lys Ile Gly Asp Lys 
1               5                   10                  15      

Lys Tyr Arg Val Arg Ser Val Pro Met Ile His Ser Thr Pro Pro Gln 
            20                  25                  30          

Ser Val Leu Asp Arg Asp Thr Phe Thr Ile Asp Tyr Thr Asp Asp Glu 
        35                  40                  45              

Leu Leu Asp Lys Glu Ala Val Phe Thr Thr His 
    50                  55                  

<210>   3697
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3697
atgaaaaata gaataattga tgtttttgaa gtagtaaatc gcctccttgt aataactgtt   60
gaaaatcctg atttcgaaga cttgagagtt aatcatactc aa                      102

<210>   3698
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3698
Met Lys Asn Arg Ile Ile Asp Val Phe Glu Val Val Asn Arg Leu Leu 
1               5                   10                  15      

Val Ile Thr Val Glu Asn Pro Asp Phe Glu Asp Leu Arg Val Asn His 
            20                  25                  30          

Thr Gln 
        

<210>   3699
<211>   219
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3699
atggaaatga tggaactacc aagtcaggaa attttgattt ttacaaaaca aattcgtcat   60
tggattctta gtgatcaagt tatttcaggg aaaagaaaac ttttcttccg ggaagatact   120
ccaaaagaga ttttagattt gtacgaaaac attaaatcta aacttgattt tgcttaccaa   180
gaagttcatt ctaataatgg gttgaaaaaa tatgaaaaa                          219

<210>   3700
<211>   73
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903657 (2.E-34)

<400>   3700
Met Glu Met Met Glu Leu Pro Ser Gln Glu Ile Leu Ile Phe Thr Lys 
1               5                   10                  15      

Gln Ile Arg His Trp Ile Leu Ser Asp Gln Val Ile Ser Gly Lys Arg 
            20                  25                  30          

Lys Leu Phe Phe Arg Glu Asp Thr Pro Lys Glu Ile Leu Asp Leu Tyr 
        35                  40                  45              

Glu Asn Ile Lys Ser Lys Leu Asp Phe Ala Tyr Gln Glu Val His Ser 
    50                  55                  60                  

Asn Asn Gly Leu Lys Lys Tyr Glu Lys 
65                  70              

<210>   3701
<211>   1269
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3701
atgccagaca atctcgcgct tcgcatgcgc cctaaaacca tcgaccaggt catcggtcag   60
gagcatctgg tcggacctgg aaaaatcatc cgccgcatgg tggaagccaa ccgcttgtcc   120
tccatgattc tatatggccc tcctggaatc ggcaaaacca gtattgcctc tgccatcgct   180
ggaacgacca agtatgcctt tcgaactttc aatgcgacag ttgatagtaa aaagcgactg   240
caagaaatct cggaagaagc taaattttct ggtggtctcg tcctattact agacgaaatt   300
catcgactag ataagaccaa gcaagacttc ctcttgcctc tcttggaaag tggactggtc   360
atcatgattg gagcaacgac tgaaaatcct ttcttctctg tcactcctgc cattcgtagc   420
cgagttcaaa ttttcgagtt ggaacctctg tctaaccaag acgtcaaaga ggccctgcag   480
atagctctaa gtaaccctga acgtggtttt gattttccaa tagaactaga tgaggatgcg   540
ctggatttca tcgcaacctc tacaaacgga gaccttcgct ctgcctttaa ctcactggac   600
ttagctgttc tctctacccc tgagaatgac gagggcattc gccacatcac cttagacatc   660
atggaaaata gtcttcagag aagctacatc actatggaca aggatggaga cggtcactat   720
gatgttctat ctgccctgca aaagtctatt cgtggctcag atgtggatgc cagtctccac   780
tatactgccc gcttgattga ggctggggat ctgcctagtc tcgctcgtcg cttgactgtt   840
atcgcctatg aagatatcgg cttagccaat cctgaggccc agattcatac cgtgactgct   900
ctggatgctg cccagaagat tgggttccca gaagcccgca ttctcatcgc caatgtcgtg   960
attgatttgg ccctttctcc aaaatccaac tcagcctatg tagctatgga taaggcactt   1020
gctgacctca aaacatcagg gcacttgcct attccgcgac acctgcgtga tgggcactac   1080
agtggaagca aggaactggg gaatgcccaa gactatctct atccacacaa ctatcctgga   1140
aattgggtca agcaagacta tctgccagaa aaaattcgta atcatcacta tttccaagca   1200
gaagatactg gtaaatatga acgggctttg gctcaaagaa aggaagctat cgaccgtttg   1260
cgaaaaatc                                                           1269

<210>   3702
<211>   423
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATPase, AAA family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903658 (0.E+01)

<400>   3702
Met Pro Asp Asn Leu Ala Leu Arg Met Arg Pro Lys Thr Ile Asp Gln 
1               5                   10                  15      

Val Ile Gly Gln Glu His Leu Val Gly Pro Gly Lys Ile Ile Arg Arg 
            20                  25                  30          

Met Val Glu Ala Asn Arg Leu Ser Ser Met Ile Leu Tyr Gly Pro Pro 
        35                  40                  45              

Gly Ile Gly Lys Thr Ser Ile Ala Ser Ala Ile Ala Gly Thr Thr Lys 
    50                  55                  60                  

Tyr Ala Phe Arg Thr Phe Asn Ala Thr Val Asp Ser Lys Lys Arg Leu 
65                  70                  75                  80  

Gln Glu Ile Ser Glu Glu Ala Lys Phe Ser Gly Gly Leu Val Leu Leu 
                85                  90                  95      

Leu Asp Glu Ile His Arg Leu Asp Lys Thr Lys Gln Asp Phe Leu Leu 
            100                 105                 110         

Pro Leu Leu Glu Ser Gly Leu Val Ile Met Ile Gly Ala Thr Thr Glu 
        115                 120                 125             

Asn Pro Phe Phe Ser Val Thr Pro Ala Ile Arg Ser Arg Val Gln Ile 
    130                 135                 140                 

Phe Glu Leu Glu Pro Leu Ser Asn Gln Asp Val Lys Glu Ala Leu Gln 
145                 150                 155                 160 

Ile Ala Leu Ser Asn Pro Glu Arg Gly Phe Asp Phe Pro Ile Glu Leu 
                165                 170                 175     

Asp Glu Asp Ala Leu Asp Phe Ile Ala Thr Ser Thr Asn Gly Asp Leu 
            180                 185                 190         

Arg Ser Ala Phe Asn Ser Leu Asp Leu Ala Val Leu Ser Thr Pro Glu 
        195                 200                 205             

Asn Asp Glu Gly Ile Arg His Ile Thr Leu Asp Ile Met Glu Asn Ser 
    210                 215                 220                 

Leu Gln Arg Ser Tyr Ile Thr Met Asp Lys Asp Gly Asp Gly His Tyr 
225                 230                 235                 240 

Asp Val Leu Ser Ala Leu Gln Lys Ser Ile Arg Gly Ser Asp Val Asp 
                245                 250                 255     

Ala Ser Leu His Tyr Thr Ala Arg Leu Ile Glu Ala Gly Asp Leu Pro 
            260                 265                 270         

Ser Leu Ala Arg Arg Leu Thr Val Ile Ala Tyr Glu Asp Ile Gly Leu 
        275                 280                 285             

Ala Asn Pro Glu Ala Gln Ile His Thr Val Thr Ala Leu Asp Ala Ala 
    290                 295                 300                 

Gln Lys Ile Gly Phe Pro Glu Ala Arg Ile Leu Ile Ala Asn Val Val 
305                 310                 315                 320 

Ile Asp Leu Ala Leu Ser Pro Lys Ser Asn Ser Ala Tyr Val Ala Met 
                325                 330                 335     

Asp Lys Ala Leu Ala Asp Leu Lys Thr Ser Gly His Leu Pro Ile Pro 
            340                 345                 350         

Arg His Leu Arg Asp Gly His Tyr Ser Gly Ser Lys Glu Leu Gly Asn 
        355                 360                 365             

Ala Gln Asp Tyr Leu Tyr Pro His Asn Tyr Pro Gly Asn Trp Val Lys 
    370                 375                 380                 

Gln Asp Tyr Leu Pro Glu Lys Ile Arg Asn His His Tyr Phe Gln Ala 
385                 390                 395                 400 

Glu Asp Thr Gly Lys Tyr Glu Arg Ala Leu Ala Gln Arg Lys Glu Ala 
                405                 410                 415     

Ile Asp Arg Leu Arg Lys Ile 
            420             

<210>   3703
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3703
ttgacaaaga gccaaatttt aggacataaa gatatctcca tgttgattga cgtttatggg   60
cataccttgg aggaaaaaat tagtgaggag tttatggctg tgaaaagttt gttg         114

<210>   3704
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   integrase-related protein
<223>   Cellular location: cytoplasm

<400>   3704
Met Thr Lys Ser Gln Ile Leu Gly His Lys Asp Ile Ser Met Leu Ile 
1               5                   10                  15      

Asp Val Tyr Gly His Thr Leu Glu Glu Lys Ile Ser Glu Glu Phe Met 
            20                  25                  30          

Ala Val Lys Ser Leu Leu 
        35              

<210>   3705
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3705
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tatccagatt   60
ttagacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accttctaaa   180
attccttatc ttgaaacgac tggtatgcct actagaattc tccttagaaa gcgtcgattc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ctatcgtcaa gaagaatcac   300
caaatccctc gtatcatcaa ccaaaaaatt gctcaaaagt taattgaaaa gatttctatg   360
actgatattg cccatcagct ttccatctca acttcaactg ttattcgtaa gctcaatgac   420
tttcacttta aacatgattt ttcttgtctt cctgagatta tgtcttggga tgagtatgct   480
tttacaaagg gaaagatgag cttcattgcg caagatttta acaatctcaa tatcatcact   540
gttcttgagg gaagaacaca agctatcatt cgaaatcact ttcttaaata tgatagagcc   600
gtccgatgtc gcgtcaaaat tattactatg gatatgttta gtccttacta tgacttagct   660
agacaacttt tcccatgtgc taaaatcgtg ttggatcgct ttcacattgt acaacatctt   720
agccgtgcta tgagtcgtgt gcgtgttcaa atcatgaatc aattggatcg aaagtctcat   780
gaatacaagg ctatcaagcg ctactggaag ctcatacaac aggatagtcg taaactcagc   840
gataaacatt tttatcgccc tacttttcgt atgcatttaa ccaataaaga gattttaaac   900
aagcttttga gctattcaca agacttgaaa catcactatc agctctatca actcttgctg   960
tttcactttc agaataagga accggagaaa tttttcggac tcattgagga caatctaaag   1020
caggttcctc ctctttttca gactgtcttt aaaacctttc taaaggacaa agagaaaatc   1080
gtcaacgccc ttcaactaca ctattctaac gccaaattgg aagcgaccaa taatctcatc   1140
aaacttatca agcgcaatgc ctttggtttt cggaactttg aaaacttcaa aaaacggatt   1200
tttatcgctc tgaatatcaa aaaagaaagg acaaaatttg tcctttctcg agct         1254

<210>   3706
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903763 (0.E+01)

<400>   3706
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ser 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Lys 
    130                 135                 140                 

His Asp Phe Ser Cys Leu Pro Glu Ile Met Ser Trp Asp Glu Tyr Ala 
145                 150                 155                 160 

Phe Thr Lys Gly Lys Met Ser Phe Ile Ala Gln Asp Phe Asn Asn Leu 
                165                 170                 175     

Asn Ile Ile Thr Val Leu Glu Gly Arg Thr Gln Ala Ile Ile Arg Asn 
            180                 185                 190         

His Phe Leu Lys Tyr Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile 
        195                 200                 205             

Thr Met Asp Met Phe Ser Pro Tyr Tyr Asp Leu Ala Arg Gln Leu Phe 
    210                 215                 220                 

Pro Cys Ala Lys Ile Val Leu Asp Arg Phe His Ile Val Gln His Leu 
225                 230                 235                 240 

Ser Arg Ala Met Ser Arg Val Arg Val Gln Ile Met Asn Gln Leu Asp 
                245                 250                 255     

Arg Lys Ser His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile 
            260                 265                 270         

Gln Gln Asp Ser Arg Lys Leu Ser Asp Lys His Phe Tyr Arg Pro Thr 
        275                 280                 285             

Phe Arg Met His Leu Thr Asn Lys Glu Ile Leu Asn Lys Leu Leu Ser 
    290                 295                 300                 

Tyr Ser Gln Asp Leu Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu 
305                 310                 315                 320 

Phe His Phe Gln Asn Lys Glu Pro Glu Lys Phe Phe Gly Leu Ile Glu 
                325                 330                 335     

Asp Asn Leu Lys Gln Val Pro Pro Leu Phe Gln Thr Val Phe Lys Thr 
            340                 345                 350         

Phe Leu Lys Asp Lys Glu Lys Ile Val Asn Ala Leu Gln Leu His Tyr 
        355                 360                 365             

Ser Asn Ala Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys 
    370                 375                 380                 

Arg Asn Ala Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile 
385                 390                 395                 400 

Phe Ile Ala Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser 
                405                 410                 415     

Arg Ala 
        

<210>   3707
<211>   273
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3707
ttgctagaaa atataagcca tatcgaaatt gaattattta aatttatact cttcgaaaat   60
caaattcaaa ccaagtcagc ttcgccttgc tgtactcaag tgctgtctgt ggctagcttc   120
ttagtttgct ttttgatttt cattgagtat tactcttatg gtagttattt atggcataat   180
aatattgatt tgggagttat agcgaaaatt ttaggttcta taatatttgt agtgggtaaa   240
tccactatag atattatgga gcctatttta ttg                                273

<210>   3708
<211>   91
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element, fusion

<400>   3708
Met Leu Glu Asn Ile Ser His Ile Glu Ile Glu Leu Phe Lys Phe Ile 
1               5                   10                  15      

Leu Phe Glu Asn Gln Ile Gln Thr Lys Ser Ala Ser Pro Cys Cys Thr 
            20                  25                  30          

Gln Val Leu Ser Val Ala Ser Phe Leu Val Cys Phe Leu Ile Phe Ile 
        35                  40                  45              

Glu Tyr Tyr Ser Tyr Gly Ser Tyr Leu Trp His Asn Asn Ile Asp Leu 
    50                  55                  60                  

Gly Val Ile Ala Lys Ile Leu Gly Ser Ile Ile Phe Val Val Gly Lys 
65                  70                  75                  80  

Ser Thr Ile Asp Ile Met Glu Pro Ile Leu Leu 
                85                  90      

<210>   3709
<211>   573
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3709
atgaaacaaa aacaaccgat tgtttctaga acgaaacaac atacatttga agagcttatt   60
caagaccaaa agttagaaag attggctaag ttgtcgcccg atttggttgg aaggtatggt   120
tttactgcta gctgtgcgtc ttcatttgcg aacttgatta aagaagcgta tgggggtaaa   180
aatctaaacg tagtttatgc gagtcggatg ttggctctct ggaatattgc ttgcagttgt   240
tatcataagg ctgatgggta ttctttagca gatgcgcttt ttagtgataa aaaaatttgt   300
ctagattctt actattacca caagaatacc tctaatacca taactagtga tgtgataaaa   360
gatgtttacg ataattataa taattatatg gttttaactc gagaagcgac acctgaatac   420
atttatgttg tacaaactga aatgccaaaa gattcagatt tatattttta tattagagaa   480
gttctgggat tatcgtttag taccatgcat tatgcatttt tagtcaaggt tcttgcagga   540
gcgcttgcta gaaaatataa gccatatcga aat                                573

<210>   3710
<211>   191
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3710
Met Lys Gln Lys Gln Pro Ile Val Ser Arg Thr Lys Gln His Thr Phe 
1               5                   10                  15      

Glu Glu Leu Ile Gln Asp Gln Lys Leu Glu Arg Leu Ala Lys Leu Ser 
            20                  25                  30          

Pro Asp Leu Val Gly Arg Tyr Gly Phe Thr Ala Ser Cys Ala Ser Ser 
        35                  40                  45              

Phe Ala Asn Leu Ile Lys Glu Ala Tyr Gly Gly Lys Asn Leu Asn Val 
    50                  55                  60                  

Val Tyr Ala Ser Arg Met Leu Ala Leu Trp Asn Ile Ala Cys Ser Cys 
65                  70                  75                  80  

Tyr His Lys Ala Asp Gly Tyr Ser Leu Ala Asp Ala Leu Phe Ser Asp 
                85                  90                  95      

Lys Lys Ile Cys Leu Asp Ser Tyr Tyr Tyr His Lys Asn Thr Ser Asn 
            100                 105                 110         

Thr Ile Thr Ser Asp Val Ile Lys Asp Val Tyr Asp Asn Tyr Asn Asn 
        115                 120                 125             

Tyr Met Val Leu Thr Arg Glu Ala Thr Pro Glu Tyr Ile Tyr Val Val 
    130                 135                 140                 

Gln Thr Glu Met Pro Lys Asp Ser Asp Leu Tyr Phe Tyr Ile Arg Glu 
145                 150                 155                 160 

Val Leu Gly Leu Ser Phe Ser Thr Met His Tyr Ala Phe Leu Val Lys 
                165                 170                 175     

Val Leu Ala Gly Ala Leu Ala Arg Lys Tyr Lys Pro Tyr Arg Asn 
            180                 185                 190     

<210>   3711
<211>   423
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3711
ttggaggaac tgatgaagaa caatgaaaga ttaggtatta aattaagtag agatagcgtt   60
ttaggattga gggaagttag aaggctttat ttaggcagtt cagatatccc agtttctgat   120
ggctatgtga ttgaagttgc ttataaccag atatcacatg agattgatat tattgattgg   180
gtagagttga acaagtcaaa aattaagata agtgaaatta gtgaaagcgt ggatatagat   240
gccactagct tgagaacaac tttgacttta gacacattag tatatgaagg tatgagagat   300
atacagttaa agttgagaga gcttacaaag gggagagtat tcttttcatt tgtagtgaag   360
ttagttttgt ttgcttctat tttaaagaaa aaagatttac tagaaaaatt tcaagaaaag   420
tgt                                                                 423

<210>   3712
<211>   141
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   3712
Met Glu Glu Leu Met Lys Asn Asn Glu Arg Leu Gly Ile Lys Leu Ser 
1               5                   10                  15      

Arg Asp Ser Val Leu Gly Leu Arg Glu Val Arg Arg Leu Tyr Leu Gly 
            20                  25                  30          

Ser Ser Asp Ile Pro Val Ser Asp Gly Tyr Val Ile Glu Val Ala Tyr 
        35                  40                  45              

Asn Gln Ile Ser His Glu Ile Asp Ile Ile Asp Trp Val Glu Leu Asn 
    50                  55                  60                  

Lys Ser Lys Ile Lys Ile Ser Glu Ile Ser Glu Ser Val Asp Ile Asp 
65                  70                  75                  80  

Ala Thr Ser Leu Arg Thr Thr Leu Thr Leu Asp Thr Leu Val Tyr Glu 
                85                  90                  95      

Gly Met Arg Asp Ile Gln Leu Lys Leu Arg Glu Leu Thr Lys Gly Arg 
            100                 105                 110         

Val Phe Phe Ser Phe Val Val Lys Leu Val Leu Phe Ala Ser Ile Leu 
        115                 120                 125             

Lys Lys Lys Asp Leu Leu Glu Lys Phe Gln Glu Lys Cys 
    130                 135                 140     

<210>   3713
<211>   1323
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3713
ttgattatgg gagataagaa atacacagta gaaaaagcca atcgttttat agcagaaaat   60
aaacatctcg ttaatactca atataagcct gaagaacatt tttcagctga gattggttgg   120
atcaatgatc caaatggatt tgtctatttt cgtggagaat accatctctt ttatcaattc   180
tatccatatg atagtgtttg ggggcctatg cactggggac atgctaaaag taaggacttg   240
gtgacttggg agcacttgcc agtggcactt gctcctgacc aagattatga ccgaaatggt   300
tgtttctcag gctctgccat tgtcaaggat gatcgcctct ggctcatgta cactggacat   360
atcgaagaag aaaccggtgt ccgccaagtg caaaatatgg tattttcaga tgacgggatt   420
cactttgaaa agatttccca aaatccagtt gcaactggat cagacttacc agatgagttg   480
attgctgctg atttccgtga tccaaaactc tttgaaaaag atggacgcta ttactccgta   540
gtagctgcca aacacaagga taatgtgggc tgtatcgttc tactagggtc cgataaccta   600
gtagaatggc agttcgaatc catcttttta aaagggggag aacaccaagg ttttatgtgg   660
gaatgcccag attacttcga gttagatggg aaagattgcc ttattatgtc acccatgcgt   720
tatcagcgtg agggagactc atatcataac atcaactcat cgcttttgtt cacgggtaag   780
gtagattgga gagaaaaacg ttttatccca gaatcagttc aagaaattga tcatggccaa   840
gacttctatg cgcctcaaac attgttggac gatcaaaatc gtcgtatcct gattgcttgg   900
atgcagacat gggggcgtac ccttccaacc catgaccaag aacacaagtg ggcatgtgcc   960
atgactctac ctagaattct aagattggaa gatggcaaac taagacaatt ccctgttaaa   1020
aaaggccaat atcaaatcca aatagataaa gattgtcatt accacttagg aaatgatata   1080
gattatcttg aatttggtta tgacagtaat gcgcagcaag tttacattga tcgtagccat   1140
cttattcaaa aaattctagg tgaagaagaa caggacacta gtcgacggta tgtagatatt   1200
gaagctaaag aattggaagt tgttctagat aaaaattcca tcgagatttt tgtcaatcaa   1260
ggtgaagcaa gcttgactgc aacttattac ttaacggtgc cagctgagct atcacgaatt   1320
gat                                                                 1323

<210>   3714
<211>   441
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sucrose-6-phosphate hydrolase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903659 (0.E+01)

<400>   3714
Met Ile Met Gly Asp Lys Lys Tyr Thr Val Glu Lys Ala Asn Arg Phe 
1               5                   10                  15      

Ile Ala Glu Asn Lys His Leu Val Asn Thr Gln Tyr Lys Pro Glu Glu 
            20                  25                  30          

His Phe Ser Ala Glu Ile Gly Trp Ile Asn Asp Pro Asn Gly Phe Val 
        35                  40                  45              

Tyr Phe Arg Gly Glu Tyr His Leu Phe Tyr Gln Phe Tyr Pro Tyr Asp 
    50                  55                  60                  

Ser Val Trp Gly Pro Met His Trp Gly His Ala Lys Ser Lys Asp Leu 
65                  70                  75                  80  

Val Thr Trp Glu His Leu Pro Val Ala Leu Ala Pro Asp Gln Asp Tyr 
                85                  90                  95      

Asp Arg Asn Gly Cys Phe Ser Gly Ser Ala Ile Val Lys Asp Asp Arg 
            100                 105                 110         

Leu Trp Leu Met Tyr Thr Gly His Ile Glu Glu Glu Thr Gly Val Arg 
        115                 120                 125             

Gln Val Gln Asn Met Val Phe Ser Asp Asp Gly Ile His Phe Glu Lys 
    130                 135                 140                 

Ile Ser Gln Asn Pro Val Ala Thr Gly Ser Asp Leu Pro Asp Glu Leu 
145                 150                 155                 160 

Ile Ala Ala Asp Phe Arg Asp Pro Lys Leu Phe Glu Lys Asp Gly Arg 
                165                 170                 175     

Tyr Tyr Ser Val Val Ala Ala Lys His Lys Asp Asn Val Gly Cys Ile 
            180                 185                 190         

Val Leu Leu Gly Ser Asp Asn Leu Val Glu Trp Gln Phe Glu Ser Ile 
        195                 200                 205             

Phe Leu Lys Gly Gly Glu His Gln Gly Phe Met Trp Glu Cys Pro Asp 
    210                 215                 220                 

Tyr Phe Glu Leu Asp Gly Lys Asp Cys Leu Ile Met Ser Pro Met Arg 
225                 230                 235                 240 

Tyr Gln Arg Glu Gly Asp Ser Tyr His Asn Ile Asn Ser Ser Leu Leu 
                245                 250                 255     


Phe Thr Gly Lys Val Asp Trp Arg Glu Lys Arg Phe Ile Pro Glu Ser 
            260                 265                 270         

Val Gln Glu Ile Asp His Gly Gln Asp Phe Tyr Ala Pro Gln Thr Leu 
        275                 280                 285             

Leu Asp Asp Gln Asn Arg Arg Ile Leu Ile Ala Trp Met Gln Thr Trp 
    290                 295                 300                 

Gly Arg Thr Leu Pro Thr His Asp Gln Glu His Lys Trp Ala Cys Ala 
305                 310                 315                 320 

Met Thr Leu Pro Arg Ile Leu Arg Leu Glu Asp Gly Lys Leu Arg Gln 
                325                 330                 335     

Phe Pro Val Lys Lys Gly Gln Tyr Gln Ile Gln Ile Asp Lys Asp Cys 
            340                 345                 350         

His Tyr His Leu Gly Asn Asp Ile Asp Tyr Leu Glu Phe Gly Tyr Asp 
        355                 360                 365             

Ser Asn Ala Gln Gln Val Tyr Ile Asp Arg Ser His Leu Ile Gln Lys 
    370                 375                 380                 

Ile Leu Gly Glu Glu Glu Gln Asp Thr Ser Arg Arg Tyr Val Asp Ile 
385                 390                 395                 400 

Glu Ala Lys Glu Leu Glu Val Val Leu Asp Lys Asn Ser Ile Glu Ile 
                405                 410                 415     

Phe Val Asn Gln Gly Glu Ala Ser Leu Thr Ala Thr Tyr Tyr Leu Thr 
            420                 425                 430         

Val Pro Ala Glu Leu Ser Arg Ile Asp 
        435                 440     

<210>   3715
<211>   1614
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3715
atgaaattca aaacattctc aaaatcagca gttttgttga cagctagttt agcagtactt   60
gcagcctgtg gctcaaaaaa tacagcttca agtccagatt ataagttgga aggtgtaaca   120
ttcccgcttc aagaaaagaa aacattgaag tttatgacag ccagttcacc gttatctcct   180
aaagacccaa atgaaaagtt aattttgcaa cgtttggaga aggaaactgg cgttcatatt   240
gactggacca actaccaatc cgactttgca gaaaaacgta acttggatat ttctagtggt   300
gatttaccag atgctatcca caacgacgga gcttcagatg tggacttgat gaactgggct   360
aaaaaaggtg ttattattcc agttgaagat ttgattgata aatacatgcc aaatcttaag   420
aaaattttgg atgagaaacc agagtacaag gccttgatga cagcacctga tgggcacatt   480
tactcatttc catggattga agagcttgga gatggtaaag agtctattca cagtgtcaac   540
gatatggctt ggattaacaa agattggctt aagaaacttg gtcttgaaat gccaaaaact   600
actgatgatt tgattaaagt cctagaagct ttcaaaaacg gggatccaaa tggaaatgga   660
gaggctgatg aaattccatt ttcatttatt agtggtaacg gaaacgaaga ttttaaattc   720
ctatttgctg catttggtat aggggataac gatgatcatt tagtagtagg aaatgatggc   780
aaagttgact tcacagcaga taacgataac tataaagaag gtgtcaaatt tatccgtcaa   840
ttgcaagaaa aaggcctgat tgataaagaa gctttcgaac atgattggaa tagttacatt   900
gctaaaggtc atgatcagaa atttggtgtt tactttacat gggataagaa taatgttact   960
ggaagtaacg aaagttatga tgttttacca gtacttgctg gaccaagtgg tcaaaaacac   1020
gtagctcgta caaacggtat gggatttgca cgtgacaaga tggttattac cagtgtaaac   1080
aaaaacctag aattgacagc taaatggatt gatgcacaat acgctccact ccaatctgtg   1140
caaaataact ggggaactta cggagatgac aaacaacaaa acatctttga attggatcaa   1200
gcgtcaaata gtctaaaaca cttaccacta aacggaactg caccagcaga acttcgtcaa   1260
aagactgaag taggaggacc actagctatc ctagattcat actatggtaa agtaacaacc   1320
atgcctgatg atgccaaatg gcgtttggat cttatcaaag aatattatgt tccttacatg   1380
agcaatgtca ataactatcc aagagtcttt atgacacagg aagatttgga caagattgcc   1440
catatcgaag cagatatgaa tgactatatc taccgtaaac gtgctgaatg gattgtaaat   1500
ggcaatattg atactgagtg ggatgattac aagaaagaac ttgaaaaata cggactttct   1560
gattacctcg ctattaaaca aaaatactac gaccaatacc aagcaaacaa aaac         1614

<210>   3716
<211>   538
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, substrate-binding protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903577 (8.E-07)

<400>   3716
Met Lys Phe Lys Thr Phe Ser Lys Ser Ala Val Leu Leu Thr Ala Ser 
1               5                   10                  15      

Leu Ala Val Leu Ala Ala Cys Gly Ser Lys Asn Thr Ala Ser Ser Pro 
            20                  25                  30          

Asp Tyr Lys Leu Glu Gly Val Thr Phe Pro Leu Gln Glu Lys Lys Thr 
        35                  40                  45              

Leu Lys Phe Met Thr Ala Ser Ser Pro Leu Ser Pro Lys Asp Pro Asn 
    50                  55                  60                  

Glu Lys Leu Ile Leu Gln Arg Leu Glu Lys Glu Thr Gly Val His Ile 
65                  70                  75                  80  

Asp Trp Thr Asn Tyr Gln Ser Asp Phe Ala Glu Lys Arg Asn Leu Asp 
                85                  90                  95      

Ile Ser Ser Gly Asp Leu Pro Asp Ala Ile His Asn Asp Gly Ala Ser 
            100                 105                 110         

Asp Val Asp Leu Met Asn Trp Ala Lys Lys Gly Val Ile Ile Pro Val 
        115                 120                 125             

Glu Asp Leu Ile Asp Lys Tyr Met Pro Asn Leu Lys Lys Ile Leu Asp 
    130                 135                 140                 

Glu Lys Pro Glu Tyr Lys Ala Leu Met Thr Ala Pro Asp Gly His Ile 
145                 150                 155                 160 

Tyr Ser Phe Pro Trp Ile Glu Glu Leu Gly Asp Gly Lys Glu Ser Ile 
                165                 170                 175     

His Ser Val Asn Asp Met Ala Trp Ile Asn Lys Asp Trp Leu Lys Lys 
            180                 185                 190         

Leu Gly Leu Glu Met Pro Lys Thr Thr Asp Asp Leu Ile Lys Val Leu 
        195                 200                 205             

Glu Ala Phe Lys Asn Gly Asp Pro Asn Gly Asn Gly Glu Ala Asp Glu 
    210                 215                 220                 

Ile Pro Phe Ser Phe Ile Ser Gly Asn Gly Asn Glu Asp Phe Lys Phe 
225                 230                 235                 240 

Leu Phe Ala Ala Phe Gly Ile Gly Asp Asn Asp Asp His Leu Val Val 
                245                 250                 255     

Gly Asn Asp Gly Lys Val Asp Phe Thr Ala Asp Asn Asp Asn Tyr Lys 
            260                 265                 270         

Glu Gly Val Lys Phe Ile Arg Gln Leu Gln Glu Lys Gly Leu Ile Asp 
        275                 280                 285             

Lys Glu Ala Phe Glu His Asp Trp Asn Ser Tyr Ile Ala Lys Gly His 
    290                 295                 300                 

Asp Gln Lys Phe Gly Val Tyr Phe Thr Trp Asp Lys Asn Asn Val Thr 
305                 310                 315                 320 

Gly Ser Asn Glu Ser Tyr Asp Val Leu Pro Val Leu Ala Gly Pro Ser 
                325                 330                 335     

Gly Gln Lys His Val Ala Arg Thr Asn Gly Met Gly Phe Ala Arg Asp 
            340                 345                 350         

Lys Met Val Ile Thr Ser Val Asn Lys Asn Leu Glu Leu Thr Ala Lys 
        355                 360                 365             

Trp Ile Asp Ala Gln Tyr Ala Pro Leu Gln Ser Val Gln Asn Asn Trp 
    370                 375                 380                 

Gly Thr Tyr Gly Asp Asp Lys Gln Gln Asn Ile Phe Glu Leu Asp Gln 
385                 390                 395                 400 

Ala Ser Asn Ser Leu Lys His Leu Pro Leu Asn Gly Thr Ala Pro Ala 
                405                 410                 415     

Glu Leu Arg Gln Lys Thr Glu Val Gly Gly Pro Leu Ala Ile Leu Asp 
            420                 425                 430         

Ser Tyr Tyr Gly Lys Val Thr Thr Met Pro Asp Asp Ala Lys Trp Arg 
        435                 440                 445             

Leu Asp Leu Ile Lys Glu Tyr Tyr Val Pro Tyr Met Ser Asn Val Asn 
    450                 455                 460                 

Asn Tyr Pro Arg Val Phe Met Thr Gln Glu Asp Leu Asp Lys Ile Ala 
465                 470                 475                 480 

His Ile Glu Ala Asp Met Asn Asp Tyr Ile Tyr Arg Lys Arg Ala Glu 
                485                 490                 495     

Trp Ile Val Asn Gly Asn Ile Asp Thr Glu Trp Asp Asp Tyr Lys Lys 
            500                 505                 510         

Glu Leu Glu Lys Tyr Gly Leu Ser Asp Tyr Leu Ala Ile Lys Gln Lys 
        515                 520                 525             

Tyr Tyr Asp Gln Tyr Gln Ala Asn Lys Asn 
    530                 535             

<210>   3717
<211>   915
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3717
atggtgaagg aatttaagga ggaaagtatg aaaaattcga ttatggatac aaaatttgat   60
agacgtatct tactcttaaa taaaatcatt attgtcttta tcgttttgat gactttgctt   120
cctttacttt atatcgtcgt agcatccttt atggatccta aggttctggt tagtagaggg   180
attagcttta atccagccga ttggactgta gaaggttacc agcgtgtatt cagtgaccaa   240
tctattctaa gaggttttat caattctcta ctatactctt ttggatttgc agctttaaca   300
gtcttgctat ctgtgtttac agcttatcct ctttctaaga aagacttggt tggacgtcgt   360
tggattaact acttcttgat tgtaactatg ttctttggtg gtggtttagt cccaacttac   420
ttgctcgtaa aagaattggg aatgctcaat actccatggg ctatcattgt tccaggtgct   480

gttaacgttt ggaatattat tcttgctagg gcctatttcc aaggattgcc tgaagaatta   540
gttgaagctg ctgtcattga tggtgcaaat gatttacaga ttttcttcaa aatcatgctt   600
cctcttgcaa aaccaattat gtttgttctc ttcctttatg cttttgtagg acagtggaac   660
tcatactttg atgcaatgat ttatatcaag gatccaaact tggaaccatt gcaacttgta   720
cttcgtaaaa ttctcattca gagccaacca ggtcaagaca tgattggagc acaagcggct   780
atgaatgaaa tgaaacgttt agctgaattg attaaatacg caactattgt catttccagc   840
ttgccattga ttgttatgta tccattcttc caaaaatact ttgataaagg aattatggct   900
ggttcactta aagga                                                    915

<210>   3718
<211>   305
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902126 (5.E-46)

<400>   3718
Met Val Lys Glu Phe Lys Glu Glu Ser Met Lys Asn Ser Ile Met Asp 
1               5                   10                  15      

Thr Lys Phe Asp Arg Arg Ile Leu Leu Leu Asn Lys Ile Ile Ile Val 
            20                  25                  30          

Phe Ile Val Leu Met Thr Leu Leu Pro Leu Leu Tyr Ile Val Val Ala 
        35                  40                  45              

Ser Phe Met Asp Pro Lys Val Leu Val Ser Arg Gly Ile Ser Phe Asn 
    50                  55                  60                  

Pro Ala Asp Trp Thr Val Glu Gly Tyr Gln Arg Val Phe Ser Asp Gln 
65                  70                  75                  80  

Ser Ile Leu Arg Gly Phe Ile Asn Ser Leu Leu Tyr Ser Phe Gly Phe 
                85                  90                  95      

Ala Ala Leu Thr Val Leu Leu Ser Val Phe Thr Ala Tyr Pro Leu Ser 
            100                 105                 110         

Lys Lys Asp Leu Val Gly Arg Arg Trp Ile Asn Tyr Phe Leu Ile Val 
        115                 120                 125             

Thr Met Phe Phe Gly Gly Gly Leu Val Pro Thr Tyr Leu Leu Val Lys 
    130                 135                 140                 

Glu Leu Gly Met Leu Asn Thr Pro Trp Ala Ile Ile Val Pro Gly Ala 
145                 150                 155                 160 

Val Asn Val Trp Asn Ile Ile Leu Ala Arg Ala Tyr Phe Gln Gly Leu 
                165                 170                 175     

Pro Glu Glu Leu Val Glu Ala Ala Val Ile Asp Gly Ala Asn Asp Leu 
            180                 185                 190         

Gln Ile Phe Phe Lys Ile Met Leu Pro Leu Ala Lys Pro Ile Met Phe 
        195                 200                 205             

Val Leu Phe Leu Tyr Ala Phe Val Gly Gln Trp Asn Ser Tyr Phe Asp 
    210                 215                 220                 

Ala Met Ile Tyr Ile Lys Asp Pro Asn Leu Glu Pro Leu Gln Leu Val 
225                 230                 235                 240 

Leu Arg Lys Ile Leu Ile Gln Ser Gln Pro Gly Gln Asp Met Ile Gly 
                245                 250                 255     

Ala Gln Ala Ala Met Asn Glu Met Lys Arg Leu Ala Glu Leu Ile Lys 
            260                 265                 270         

Tyr Ala Thr Ile Val Ile Ser Ser Leu Pro Leu Ile Val Met Tyr Pro 

        275                 280                 285             

Phe Phe Gln Lys Tyr Phe Asp Lys Gly Ile Met Ala Gly Ser Leu Lys 
    290                 295                 300                 

Gly 
305 

<210>   3719
<211>   915
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   3719
atgaatagca aagcgaagca agtttctctt tgggaaagaa tcaagaaaca aaaactcttg   60
ttattgatga ctgtccccgg tttagtttta acctttatct ttaaatacat ccctatgtat   120
ggggttttaa tcgcatttaa agattacaat cctttaaaag gaattttagg gagtgattgg   180
attggttttt ctgagtttac aaaattcata tcctctccca actttggtat cttgttagcc   240
aacacattaa aattaagtat ctatggttta ttgcttggct ttttaccacc aatcattctc   300
gcgattatgc tcaatcaact cttgagtgaa aaagtcaaaa aacgaattca gctcatttta   360
tacgcaccaa actttatctc agtcgttgtt attgtcggta tgattttcct cttcttttca   420
gtgggaggac caatcaacaa ttttctttct atgtttggaa tgaaggctga cttcttgaca   480
aatccagact tctttagacc tttatacatc tttagtggta tctggcaagg aatgggctgg   540
gcttcaacgc tctacacggc aacattggta aatgtagatc cagccttagt agaagcagcc   600
cgactggatg gagccaatat cttccaacga atctggcaca ttgatattcc agctcttaag   660
cctattatgg ttatccaatt tgttttagct gcaggtggaa ttatgaatgt cggatatgaa   720
aaagcattct tgatgcagac atcgttaaat ttgccaactt ctgaaattat ctcgacatat   780
gtctataaag ttggtcttgt atcaggagac tattcttact caacagcggt tggtttgttt   840
aatgcagtga ttaacgtagt attgcttgtt gcagttaacc aaatcgttaa acgcatgaat   900
aatggtgaag gaatt                                                    915

<210>   3720
<211>   305
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902125 (1.E-39)

<400>   3720
Met Asn Ser Lys Ala Lys Gln Val Ser Leu Trp Glu Arg Ile Lys Lys 
1               5                   10                  15      

Gln Lys Leu Leu Leu Leu Met Thr Val Pro Gly Leu Val Leu Thr Phe 
            20                  25                  30          

Ile Phe Lys Tyr Ile Pro Met Tyr Gly Val Leu Ile Ala Phe Lys Asp 
        35                  40                  45              

Tyr Asn Pro Leu Lys Gly Ile Leu Gly Ser Asp Trp Ile Gly Phe Ser 
    50                  55                  60                  

Glu Phe Thr Lys Phe Ile Ser Ser Pro Asn Phe Gly Ile Leu Leu Ala 
65                  70                  75                  80  

Asn Thr Leu Lys Leu Ser Ile Tyr Gly Leu Leu Leu Gly Phe Leu Pro 
                85                  90                  95      

Pro Ile Ile Leu Ala Ile Met Leu Asn Gln Leu Leu Ser Glu Lys Val 
            100                 105                 110         

Lys Lys Arg Ile Gln Leu Ile Leu Tyr Ala Pro Asn Phe Ile Ser Val 
        115                 120                 125             

Val Val Ile Val Gly Met Ile Phe Leu Phe Phe Ser Val Gly Gly Pro 
    130                 135                 140                 

Ile Asn Asn Phe Leu Ser Met Phe Gly Met Lys Ala Asp Phe Leu Thr 
145                 150                 155                 160 

Asn Pro Asp Phe Phe Arg Pro Leu Tyr Ile Phe Ser Gly Ile Trp Gln 
                165                 170                 175     

Gly Met Gly Trp Ala Ser Thr Leu Tyr Thr Ala Thr Leu Val Asn Val 
            180                 185                 190         

Asp Pro Ala Leu Val Glu Ala Ala Arg Leu Asp Gly Ala Asn Ile Phe 
        195                 200                 205             

Gln Arg Ile Trp His Ile Asp Ile Pro Ala Leu Lys Pro Ile Met Val 
    210                 215                 220                 

Ile Gln Phe Val Leu Ala Ala Gly Gly Ile Met Asn Val Gly Tyr Glu 
225                 230                 235                 240 

Lys Ala Phe Leu Met Gln Thr Ser Leu Asn Leu Pro Thr Ser Glu Ile 
                245                 250                 255     

Ile Ser Thr Tyr Val Tyr Lys Val Gly Leu Val Ser Gly Asp Tyr Ser 
            260                 265                 270         

Tyr Ser Thr Ala Val Gly Leu Phe Asn Ala Val Ile Asn Val Val Leu 
        275                 280                 285             

Leu Val Ala Val Asn Gln Ile Val Lys Arg Met Asn Asn Gly Glu Gly 
    290                 295                 300                 

Ile 
305 

<210>   3721
<211>   1017
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3721
ttgaaaggag gtgataatat ggtagaacaa agaaaatcaa ttaccatgaa agatgttgct   60
ttagaagcag gagttagtgt tggaactgtt tcacgtgtaa ttaataaaga aaaaggcatt   120
aaagaagtaa ctttgaaaaa agtggaacaa gcgattaaaa ctttgaatta cattccagat   180
tactacgcta gaggaatgaa aaaaaatcga acagaaacga ttgcaatcat tgtaccaagt   240
atctggcatc ccttcttttc agaatttgct atgcatgtgg aaaatgaagt ctataagaga   300
aataacaaat tactcttatg ttctatcaat ggtacaaata gagagcaaga ctatctggag   360
atgttgcgtc ataataaagt tgatggagtg gttgccatta cctatagtcc aattgaacat   420
tacttgacgt caggaattcc ctttgttagt attgaccgca catactcaga tattgccatt   480
ccttgtgttt catcagataa tgatgcaggt ggaagagaag cagctaaaca attaattagt   540
aaaggatgtc agcatttagc ctttgtgggc ggacataata caaccattaa tgaaaccaaa   600
cgtcgtagaa tttcatttga aaagtatgtc caagagcata aaatacctct tagtattttt   660
gatttggatg agacagttac tgactattat ggaaagctag agagtttctt ggaagaaaat   720
tcttctatag atggaatttt tacaatcaac gattttacag ctttggatgt gattgaaata   780
ctagaaaaaa atggcaaacg tattcctcat gatgtccaaa ttattggata cgatggaatt   840
aaaatggctg gagatagaga ttatctactt tcaactattg aacaaccatt ggaagaaatg   900
gcaaaagaag cggttcgtat tttgtttgat ataattgatg gaaagactgt taatttgcag   960
acaatcctac cagtaaaatt tgttgaagga aaaacaacaa aaaatgaaaa taagtct      1017

<210>   3722
<211>   339
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar-binding transcriptional regulator, LacI family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903663 (1.E-93)

<400>   3722
Met Lys Gly Gly Asp Asn Met Val Glu Gln Arg Lys Ser Ile Thr Met 
1               5                   10                  15      

Lys Asp Val Ala Leu Glu Ala Gly Val Ser Val Gly Thr Val Ser Arg 
            20                  25                  30          

Val Ile Asn Lys Glu Lys Gly Ile Lys Glu Val Thr Leu Lys Lys Val 
        35                  40                  45              

Glu Gln Ala Ile Lys Thr Leu Asn Tyr Ile Pro Asp Tyr Tyr Ala Arg 
    50                  55                  60                  

Gly Met Lys Lys Asn Arg Thr Glu Thr Ile Ala Ile Ile Val Pro Ser 
65                  70                  75                  80  

Ile Trp His Pro Phe Phe Ser Glu Phe Ala Met His Val Glu Asn Glu 
                85                  90                  95      

Val Tyr Lys Arg Asn Asn Lys Leu Leu Leu Cys Ser Ile Asn Gly Thr 
            100                 105                 110         

Asn Arg Glu Gln Asp Tyr Leu Glu Met Leu Arg His Asn Lys Val Asp 
        115                 120                 125             

Gly Val Val Ala Ile Thr Tyr Ser Pro Ile Glu His Tyr Leu Thr Ser 
    130                 135                 140                 

Gly Ile Pro Phe Val Ser Ile Asp Arg Thr Tyr Ser Asp Ile Ala Ile 
145                 150                 155                 160 

Pro Cys Val Ser Ser Asp Asn Asp Ala Gly Gly Arg Glu Ala Ala Lys 
                165                 170                 175     

Gln Leu Ile Ser Lys Gly Cys Gln His Leu Ala Phe Val Gly Gly His 
            180                 185                 190         

Asn Thr Thr Ile Asn Glu Thr Lys Arg Arg Arg Ile Ser Phe Glu Lys 
        195                 200                 205             

Tyr Val Gln Glu His Lys Ile Pro Leu Ser Ile Phe Asp Leu Asp Glu 
    210                 215                 220                 

Thr Val Thr Asp Tyr Tyr Gly Lys Leu Glu Ser Phe Leu Glu Glu Asn 
225                 230                 235                 240 


Ser Ser Ile Asp Gly Ile Phe Thr Ile Asn Asp Phe Thr Ala Leu Asp 
                245                 250                 255     

Val Ile Glu Ile Leu Glu Lys Asn Gly Lys Arg Ile Pro His Asp Val 
            260                 265                 270         

Gln Ile Ile Gly Tyr Asp Gly Ile Lys Met Ala Gly Asp Arg Asp Tyr 
        275                 280                 285             

Leu Leu Ser Thr Ile Glu Gln Pro Leu Glu Glu Met Ala Lys Glu Ala 
    290                 295                 300                 

Val Arg Ile Leu Phe Asp Ile Ile Asp Gly Lys Thr Val Asn Leu Gln 
305                 310                 315                 320 

Thr Ile Leu Pro Val Lys Phe Val Glu Gly Lys Thr Thr Lys Asn Glu 
                325                 330                 335     

Asn Lys Ser 
            

<210>   3723
<211>   1536
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3723
ttgtggtata attgcaagag gtttaatccg ataatttata aagagagaaa gatattcatg   60
agagatttat tatctaaaaa aagtcatagg caattagaat tattagaatt attatttgaa   120
cataaacgtt ggtttcatcg ttctgaacta gcagagttat taaattgtac agaacgtgca   180
gtcaaagatg atctatccca tgttaaatct gcttttcctg acttgatttt tcattcttct   240
actaatggta tacgcattat taataccgat gatagtgata ttgaaatggt ttaccatcat   300
ttctttaaac attcaactca tttttcgatt ttagaattca tcttctttaa tgaaggttgt   360
caagctgaga gtatttgtaa agaattttat atcagttcat cttcgctcta tcgtattatt   420
agccaaatca ataaagtgat taaaaggcaa tttcaatttg aagttagtct gacccctgtt   480
caaatcattg gaaatgagag agacattcgt tacttttttg cacaatattt ttcagaaaaa   540
tattatttcc tagaatggcc atttgaaaat ttttcatcag agccactatc tcaattgtta   600
gaattggttt ataaggaaac aagctttcca atgaatttgt caacgcatag aatgctaaag   660
ttgctcctag ttacgaacct atatagaata aagtttggtc attttatgga agtagataaa   720
gattctttta acgaccaaag tttggatttt ttaatgcagg cagaaggaat agaaggtgtt   780
gctcagagtt ttgaatcaga atacaatatc tctttagatg aagaagttgt ttgccaatta   840
tttgtgtctt actttcaaaa aatgtttttc atagatgaaa gtctctttat gaaatgcgta   900
aaaaaggata gttatgttga aaaatcttac catctattga gtgattttat tgatcagatt   960
tcagtcaagt atcagattga aatggagaat aaggataatc tgatttggca tctgcataat   1020
accgcacatc tgtatcgtca agagttgttt actgagttta ttttatttga tcaaaaaggg   1080
aatacaatca ggaactttca aaatattttt ccaaaatttg tttcagatat aaaaaaagag   1140
ctttctcact atttagagac tcttgaggtt tgttctagtt caatgatggt aaatcatcta   1200
tcttatacct tcatcactca taccaaacat ttggtgatta atttgctaca aaatcagcct   1260
aaactaaagg ttttagttat gagtaatttt gatcagtatc atgcaaaatt cgttgcagag   1320
acactttctt attattgtag caataatttt gaactggaag tttggactga attagaatta   1380
tcaaaggaat ctttagaaga ttcaccttat gatatcatta tttctaattt tattattcct   1440
cctattgaaa ataagagact catctattca aataatataa acacggtctc actcatatac   1500
ttgttaaatg ccatgatgtt tattcgatta gatgag                             1536

<210>   3724
<211>   512
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional activator, putative
<223>   Cellular location: cytoplasm
<223>   Feature of note: similar to Mga
<223>   Similar to strain R6 sequence 15903664 (0.E+01)

<400>   3724
Met Trp Tyr Asn Cys Lys Arg Phe Asn Pro Ile Ile Tyr Lys Glu Arg 
1               5                   10                  15      

Lys Ile Phe Met Arg Asp Leu Leu Ser Lys Lys Ser His Arg Gln Leu 
            20                  25                  30          

Glu Leu Leu Glu Leu Leu Phe Glu His Lys Arg Trp Phe His Arg Ser 
        35                  40                  45              

Glu Leu Ala Glu Leu Leu Asn Cys Thr Glu Arg Ala Val Lys Asp Asp 
    50                  55                  60                  

Leu Ser His Val Lys Ser Ala Phe Pro Asp Leu Ile Phe His Ser Ser 
65                  70                  75                  80  

Thr Asn Gly Ile Arg Ile Ile Asn Thr Asp Asp Ser Asp Ile Glu Met 
                85                  90                  95      

Val Tyr His His Phe Phe Lys His Ser Thr His Phe Ser Ile Leu Glu 
            100                 105                 110         

Phe Ile Phe Phe Asn Glu Gly Cys Gln Ala Glu Ser Ile Cys Lys Glu 
        115                 120                 125             

Phe Tyr Ile Ser Ser Ser Ser Leu Tyr Arg Ile Ile Ser Gln Ile Asn 
    130                 135                 140                 

Lys Val Ile Lys Arg Gln Phe Gln Phe Glu Val Ser Leu Thr Pro Val 
145                 150                 155                 160 

Gln Ile Ile Gly Asn Glu Arg Asp Ile Arg Tyr Phe Phe Ala Gln Tyr 
                165                 170                 175     

Phe Ser Glu Lys Tyr Tyr Phe Leu Glu Trp Pro Phe Glu Asn Phe Ser 
            180                 185                 190         

Ser Glu Pro Leu Ser Gln Leu Leu Glu Leu Val Tyr Lys Glu Thr Ser 
        195                 200                 205             

Phe Pro Met Asn Leu Ser Thr His Arg Met Leu Lys Leu Leu Leu Val 
    210                 215                 220                 

Thr Asn Leu Tyr Arg Ile Lys Phe Gly His Phe Met Glu Val Asp Lys 
225                 230                 235                 240 

Asp Ser Phe Asn Asp Gln Ser Leu Asp Phe Leu Met Gln Ala Glu Gly 
                245                 250                 255     

Ile Glu Gly Val Ala Gln Ser Phe Glu Ser Glu Tyr Asn Ile Ser Leu 
            260                 265                 270         

Asp Glu Glu Val Val Cys Gln Leu Phe Val Ser Tyr Phe Gln Lys Met 
        275                 280                 285             

Phe Phe Ile Asp Glu Ser Leu Phe Met Lys Cys Val Lys Lys Asp Ser 
    290                 295                 300                 

Tyr Val Glu Lys Ser Tyr His Leu Leu Ser Asp Phe Ile Asp Gln Ile 
305                 310                 315                 320 

Ser Val Lys Tyr Gln Ile Glu Met Glu Asn Lys Asp Asn Leu Ile Trp 
                325                 330                 335     

His Leu His Asn Thr Ala His Leu Tyr Arg Gln Glu Leu Phe Thr Glu 
            340                 345                 350         

Phe Ile Leu Phe Asp Gln Lys Gly Asn Thr Ile Arg Asn Phe Gln Asn 
        355                 360                 365             

Ile Phe Pro Lys Phe Val Ser Asp Ile Lys Lys Glu Leu Ser His Tyr 
    370                 375                 380                 

Leu Glu Thr Leu Glu Val Cys Ser Ser Ser Met Met Val Asn His Leu 
385                 390                 395                 400 

Ser Tyr Thr Phe Ile Thr His Thr Lys His Leu Val Ile Asn Leu Leu 
                405                 410                 415     

Gln Asn Gln Pro Lys Leu Lys Val Leu Val Met Ser Asn Phe Asp Gln 
            420                 425                 430         

Tyr His Ala Lys Phe Val Ala Glu Thr Leu Ser Tyr Tyr Cys Ser Asn 
        435                 440                 445             

Asn Phe Glu Leu Glu Val Trp Thr Glu Leu Glu Leu Ser Lys Glu Ser 
    450                 455                 460                 

Leu Glu Asp Ser Pro Tyr Asp Ile Ile Ile Ser Asn Phe Ile Ile Pro 
465                 470                 475                 480 

Pro Ile Glu Asn Lys Arg Leu Ile Tyr Ser Asn Asn Ile Asn Thr Val 
                485                 490                 495     

Ser Leu Ile Tyr Leu Leu Asn Ala Met Met Phe Ile Arg Leu Asp Glu 
            500                 505                 510         


<210>   3725
<211>   162
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3725
atgggaatca tcgcaaatgt attcgctggt ttagtcgggg catatgcagg acaatctctt   60
ttaggtagtt ggggtccagc aatcgctgga atggctttgc tcccatctat tgtaggtgca   120
gcgattgtga ttactgtagt gtcattcttt acaggtagaa ag                      162

<210>   3726
<211>   54
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902299 (2.E-09)

<400>   3726
Met Gly Ile Ile Ala Asn Val Phe Ala Gly Leu Val Gly Ala Tyr Ala 
1               5                   10                  15      

Gly Gln Ser Leu Leu Gly Ser Trp Gly Pro Ala Ile Ala Gly Met Ala 
            20                  25                  30          

Leu Leu Pro Ser Ile Val Gly Ala Ala Ile Val Ile Thr Val Val Ser 
        35                  40                  45              

Phe Phe Thr Gly Arg Lys 
    50                  

<210>   3727
<211>   570
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3727
ttgtatatgt caaaagcaaa gaaaatatgt ttcattattt tctgtatttt aatcttgaca   60
attttccttc ctgttttgat agattatcat caagttagtg atctaggtat tcatctactt   120
agctggagac agaactccgt agttgaattc tatcttgcta gatatgtctt ttgggggaca   180
gtggttctat caactttagt tttattatcc attttagttg tgatgtttta tcctaaacgt   240
tacttggaaa tccaacttga aactaaaaac gatacattaa aattaaagaa ttcggcaatc   300
gaaggttttg ttagaagttt ggtgagtgat catagattga tcaagaaccc aactgttcat   360
gtaaatttac gaaaaaataa atgtttcgtt catgtagaag gtaaaattct tccttcagac   420
aacatcgctg acagatgcca aataattcaa aatgaaataa ctaatggatt gaagcagttt   480
tttggtattg agcgtcaagt aaaacttgaa gttgcagtaa aaaattacca accaaaacct   540
caaaacaaaa agactgttag tcgtgtgaag                                    570

<210>   3728
<211>   190
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903665 (e-106)

<400>   3728
Met Tyr Met Ser Lys Ala Lys Lys Ile Cys Phe Ile Ile Phe Cys Ile 
1               5                   10                  15      

Leu Ile Leu Thr Ile Phe Leu Pro Val Leu Ile Asp Tyr His Gln Val 
            20                  25                  30          

Ser Asp Leu Gly Ile His Leu Leu Ser Trp Arg Gln Asn Ser Val Val 
        35                  40                  45              

Glu Phe Tyr Leu Ala Arg Tyr Val Phe Trp Gly Thr Val Val Leu Ser 
    50                  55                  60                  

Thr Leu Val Leu Leu Ser Ile Leu Val Val Met Phe Tyr Pro Lys Arg 
65                  70                  75                  80  

Tyr Leu Glu Ile Gln Leu Glu Thr Lys Asn Asp Thr Leu Lys Leu Lys 
                85                  90                  95      

Asn Ser Ala Ile Glu Gly Phe Val Arg Ser Leu Val Ser Asp His Arg 
            100                 105                 110         

Leu Ile Lys Asn Pro Thr Val His Val Asn Leu Arg Lys Asn Lys Cys 
        115                 120                 125             

Phe Val His Val Glu Gly Lys Ile Leu Pro Ser Asp Asn Ile Ala Asp 
    130                 135                 140                 

Arg Cys Gln Ile Ile Gln Asn Glu Ile Thr Asn Gly Leu Lys Gln Phe 
145                 150                 155                 160 

Phe Gly Ile Glu Arg Gln Val Lys Leu Glu Val Ala Val Lys Asn Tyr 
                165                 170                 175     

Gln Pro Lys Pro Gln Asn Lys Lys Thr Val Ser Arg Val Lys 
            180                 185                 190 

<210>   3729
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3729
atggaatggc ttaaacaata tcgatatcca attatcgctg gtctcatagg cgtatttctg   60
gcttgtttga ttgtctcctt tggcttcttc aaaacaatat ttgtattgat tttaggagca   120
ctgggagttg cagctggatt atatatcgaa aaaaactata tagataaa                168

<210>   3730
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903666 (3.E-28)

<400>   3730
Met Glu Trp Leu Lys Gln Tyr Arg Tyr Pro Ile Ile Ala Gly Leu Ile 
1               5                   10                  15      

Gly Val Phe Leu Ala Cys Leu Ile Val Ser Phe Gly Phe Phe Lys Thr 
            20                  25                  30          

Ile Phe Val Leu Ile Leu Gly Ala Leu Gly Val Ala Ala Gly Leu Tyr 
        35                  40                  45              

Ile Glu Lys Asn Tyr Ile Asp Lys 
    50                  55      

<210>   3731
<211>   606
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3731
atgtcaaacg aaaaaaacac aaacactaac gtagaaaaga aagatgctac tgttgtagct   60
cacgaaatca aaggggaact tacttacgaa gataaagtta tccaaaaaat cattggtctt   120
tcactagaaa acgtttcagg tcttttggga atcgatggtg gtttcttctc aaatcttaaa   180
gaaaaaatcg ttaacagcga tgacgtaaca agtggtgtta acgtagaagt tggtaaaaca   240
caagttgcag ttgacttaaa cgttattgtt gagtaccaaa aaaatgttcc agctttatat   300
tcagaaatca gagaaatcgt atcttcagaa gttgctaaaa tgactgactt ggaaattgtt   360
gaaatcaacg taaacgttgt cgacatcaaa actaaagaac agcatgaagc agactcagta   420
agccttcaag atcgcgtatc tgacgttgct gaatcaacag gagaattcac ttcagaacaa   480
ttcgaaaaag ctaaatctgg tcttggatct ggtttctcaa ctgttcaaga aaaagttagc   540
gaaggtgtag aagctgttaa aggtgcagca aatggtgtag tatctcacga aaacactcgt   600
gtaaac                                                              606

<210>   3732

<211>   202
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   general stress protein 24, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903667 (e-109)

<400>   3732
Met Ser Asn Glu Lys Asn Thr Asn Thr Asn Val Glu Lys Lys Asp Ala 
1               5                   10                  15      

Thr Val Val Ala His Glu Ile Lys Gly Glu Leu Thr Tyr Glu Asp Lys 
            20                  25                  30          

Val Ile Gln Lys Ile Ile Gly Leu Ser Leu Glu Asn Val Ser Gly Leu 
        35                  40                  45              

Leu Gly Ile Asp Gly Gly Phe Phe Ser Asn Leu Lys Glu Lys Ile Val 
    50                  55                  60                  

Asn Ser Asp Asp Val Thr Ser Gly Val Asn Val Glu Val Gly Lys Thr 
65                  70                  75                  80  

Gln Val Ala Val Asp Leu Asn Val Ile Val Glu Tyr Gln Lys Asn Val 
                85                  90                  95      

Pro Ala Leu Tyr Ser Glu Ile Arg Glu Ile Val Ser Ser Glu Val Ala 
            100                 105                 110         

Lys Met Thr Asp Leu Glu Ile Val Glu Ile Asn Val Asn Val Val Asp 
        115                 120                 125             

Ile Lys Thr Lys Glu Gln His Glu Ala Asp Ser Val Ser Leu Gln Asp 
    130                 135                 140                 

Arg Val Ser Asp Val Ala Glu Ser Thr Gly Glu Phe Thr Ser Glu Gln 
145                 150                 155                 160 

Phe Glu Lys Ala Lys Ser Gly Leu Gly Ser Gly Phe Ser Thr Val Gln 

                165                 170                 175     

Glu Lys Val Ser Glu Gly Val Glu Ala Val Lys Gly Ala Ala Asn Gly 
            180                 185                 190         

Val Val Ser His Glu Asn Thr Arg Val Asn 
        195                 200         

<210>   3733
<211>   201
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3733
atgtcagtag aagaaaaatt aaatcaagct aaaggttcta ttaaagaagg tgttgggaaa   60
gccatcggtg atgaaaaaat ggaaaaagaa ggtgcagctg aaaaagttgt ttctaaagta   120
aaagaagttg ccgaagacgc taaagacgct gtagaaggtg ctgtagaagg tgttaaaaac   180
atgttgagtg gcgacgataa a                                             201

<210>   3734
<211>   67
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903668 (1.E-32)

<400>   3734
Met Ser Val Glu Glu Lys Leu Asn Gln Ala Lys Gly Ser Ile Lys Glu 
1               5                   10                  15      

Gly Val Gly Lys Ala Ile Gly Asp Glu Lys Met Glu Lys Glu Gly Ala 
            20                  25                  30          

Ala Glu Lys Val Val Ser Lys Val Lys Glu Val Ala Glu Asp Ala Lys 
        35                  40                  45              

Asp Ala Val Glu Gly Ala Val Glu Gly Val Lys Asn Met Leu Ser Gly 
    50                  55                  60                  

Asp Asp Lys 
65          

<210>   3735
<211>   444
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3735
atgacaattc gttttgaaga aaaggtgagc acagaaaacg ctcaatttgt atgccagtgg   60
tccaactccc taggcaaatc ctttcaagaa caatggatgg gaccaaggat tccttttcta   120
ctgacacttc aagccttgga aggagtcttt tcaatctttg atgaacaaga gtttgtggga   180
tttatccaga aaatcaggct agaagacagc aatcttcata tcgggagatt ttttatcaac   240
ccccagaaac aggagcaagg cttaggtagc aaggctttaa ggaaatttgt tagtttagca   300
tttgaaaata gagatataga cagtatttct ctaaatgtct tcgaggcaaa tcaaagagct   360
cagaatcttt accaaaaaga aggatttgaa atcgttcaaa tggttgaagc acctgtacga   420
aaatatagta gattgaaact agaa                                          444

<210>   3736
<211>   148
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902610 (6.E-05)

<400>   3736
Met Thr Ile Arg Phe Glu Glu Lys Val Ser Thr Glu Asn Ala Gln Phe 
1               5                   10                  15      

Val Cys Gln Trp Ser Asn Ser Leu Gly Lys Ser Phe Gln Glu Gln Trp 
            20                  25                  30          

Met Gly Pro Arg Ile Pro Phe Leu Leu Thr Leu Gln Ala Leu Glu Gly 
        35                  40                  45              

Val Phe Ser Ile Phe Asp Glu Gln Glu Phe Val Gly Phe Ile Gln Lys 
    50                  55                  60                  

Ile Arg Leu Glu Asp Ser Asn Leu His Ile Gly Arg Phe Phe Ile Asn 
65                  70                  75                  80  

Pro Gln Lys Gln Glu Gln Gly Leu Gly Ser Lys Ala Leu Arg Lys Phe 
                85                  90                  95      

Val Ser Leu Ala Phe Glu Asn Arg Asp Ile Asp Ser Ile Ser Leu Asn 
            100                 105                 110         

Val Phe Glu Ala Asn Gln Arg Ala Gln Asn Leu Tyr Gln Lys Glu Gly 
        115                 120                 125             

Phe Glu Ile Val Gln Met Val Glu Ala Pro Val Arg Lys Tyr Ser Arg 
    130                 135                 140                 

Leu Lys Leu Glu 
145             

<210>   3737
<211>   657
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3737
atgattgatt tttatttttt tctcgtcggg agcattctag cttcctttct tggtttggtc   60
attgaccgtt ttccagagca atccattatc agttcagcca gtcactgcga ttcctgtcag   120
actcccttgc gtcccttaga tttgattccg attctctcac aggtcttcaa tcgctttcgc   180
tgtcgctact gcaaagttcg ctatcctgtc tggtatgccc tctttgaatt aagcttagga   240
ctcctctttc tgctttactc ttggggatgg ctctccttgg ggcaagtcgt cctaatcacc   300
gctggtttga ccttgggtat ctacgacttt caccatcagg aatatccctt actggtctgg   360
atgactttcc agctaatcct aatagcttcc tctggctgga atctggtcat ggtctccttc   420
ctcatacttg gaattttggc tcattttatc gatatccgca tgggtgcagg ggatttcctc   480

tttttagctt cttgtgctct cgtctttagc gtaacggagt tactgatctt gattcagttc   540
gcttctgcga cgggtatcct ggcctttctc ctgcaaaaga aaaaggaaag acttcctttc   600
gtgcctttcc tcttacttgc tacttgtttg attatttttg gtaagctact gcttgtc      657

<210>   3738
<211>   219
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type IV prepilin peptidase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903670 (e-116)

<400>   3738
Met Ile Asp Phe Tyr Phe Phe Leu Val Gly Ser Ile Leu Ala Ser Phe 
1               5                   10                  15      

Leu Gly Leu Val Ile Asp Arg Phe Pro Glu Gln Ser Ile Ile Ser Ser 
            20                  25                  30          

Ala Ser His Cys Asp Ser Cys Gln Thr Pro Leu Arg Pro Leu Asp Leu 
        35                  40                  45              


Ile Pro Ile Leu Ser Gln Val Phe Asn Arg Phe Arg Cys Arg Tyr Cys 
    50                  55                  60                  

Lys Val Arg Tyr Pro Val Trp Tyr Ala Leu Phe Glu Leu Ser Leu Gly 
65                  70                  75                  80  

Leu Leu Phe Leu Leu Tyr Ser Trp Gly Trp Leu Ser Leu Gly Gln Val 
                85                  90                  95      

Val Leu Ile Thr Ala Gly Leu Thr Leu Gly Ile Tyr Asp Phe His His 
            100                 105                 110         

Gln Glu Tyr Pro Leu Leu Val Trp Met Thr Phe Gln Leu Ile Leu Ile 
        115                 120                 125             

Ala Ser Ser Gly Trp Asn Leu Val Met Val Ser Phe Leu Ile Leu Gly 
    130                 135                 140                 

Ile Leu Ala His Phe Ile Asp Ile Arg Met Gly Ala Gly Asp Phe Leu 
145                 150                 155                 160 

Phe Leu Ala Ser Cys Ala Leu Val Phe Ser Val Thr Glu Leu Leu Ile 
                165                 170                 175     

Leu Ile Gln Phe Ala Ser Ala Thr Gly Ile Leu Ala Phe Leu Leu Gln 
            180                 185                 190         

Lys Lys Lys Glu Arg Leu Pro Phe Val Pro Phe Leu Leu Leu Ala Thr 
        195                 200                 205             

Cys Leu Ile Ile Phe Gly Lys Leu Leu Leu Val 
    210                 215                 

<210>   3739
<211>   1149
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3739
atgtttaatg gtcgggtatt gaaagaatta cggctgttaa atggtttaag tagagcagaa   60
ttagctcaga gaattaattt aacggaacaa gccatttggc agtttgagtc caacgaaacg   120
aaacctaaat tatcaaccaa aatgcatttg gccaaccaat ttcatgttga tttaacttat   180
tttgaacagg aagaagagag cattcgattt gattcttctg taattgcctt tagaaatgca   240
gacctagcaa cacggaaaac aatagatatt caaactatgt atttacataa ggtagatagt   300
ttgattgatt attttgaaag ttttgtaatt atacctaata ttataattca tgacctaagt   360
aatgtagtga gtgaatctta tcataaggga gaatccattg aggaattggc tctttatgcc   420
agggaaaaat taggtatttc aaaagataat catgatttgc tttataaatt agaacgttca   480
ggcatctata tcgtggaacg attaattaat ggccaagctg atgcttatag cgcatggtca   540
aaattgggaa gaccttatat tgtgttagga acgaataaat catctgtacg tcgaaatttt   600
gacttagctc atgagctagg acatattctt ttacataaat ataaagatat gaatgaagat   660
ggcgatcgtt tggagcaaga agcaaattat tttgcatcat gttttttatt gccaaaagaa   720
gagtttttag tcaaatttga agagagggtt ggcaagcgtg tcagcaatcc tgatagttat   780
attttattga agtcggattt gaatgtttcg atacaggctt tagagtatcg agcttttaag   840
ttaggattat tgactccaaa gcaacattct tacttttatc gtcaaattgc gcaaaaaggt   900
tacaaaatga ttgaaccctt ggatgatcaa atttttgtta aaaaaccaag caaagtaaag   960
agtattctgg acgtcgtttt gagtaatcat ctagtcagtc tagcgactat aatgtctaaa   1020
caaagtattc gtttacagtt tataagcgaa atattttcag tcgaaatgaa attttttgat   1080
cagtatcaag aagatagaag aacagatcga tttgataaca tcatcccttt gtacaaaaga   1140
aataattta                                                           1149

<210>   3740
<211>   383
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903671 (0.E+01)

<400>   3740
Met Phe Asn Gly Arg Val Leu Lys Glu Leu Arg Leu Leu Asn Gly Leu 
1               5                   10                  15      

Ser Arg Ala Glu Leu Ala Gln Arg Ile Asn Leu Thr Glu Gln Ala Ile 
            20                  25                  30          

Trp Gln Phe Glu Ser Asn Glu Thr Lys Pro Lys Leu Ser Thr Lys Met 
        35                  40                  45              

His Leu Ala Asn Gln Phe His Val Asp Leu Thr Tyr Phe Glu Gln Glu 
    50                  55                  60                  

Glu Glu Ser Ile Arg Phe Asp Ser Ser Val Ile Ala Phe Arg Asn Ala 
65                  70                  75                  80  

Asp Leu Ala Thr Arg Lys Thr Ile Asp Ile Gln Thr Met Tyr Leu His 
                85                  90                  95      

Lys Val Asp Ser Leu Ile Asp Tyr Phe Glu Ser Phe Val Ile Ile Pro 
            100                 105                 110         

Asn Ile Ile Ile His Asp Leu Ser Asn Val Val Ser Glu Ser Tyr His 
        115                 120                 125             

Lys Gly Glu Ser Ile Glu Glu Leu Ala Leu Tyr Ala Arg Glu Lys Leu 
    130                 135                 140                 

Gly Ile Ser Lys Asp Asn His Asp Leu Leu Tyr Lys Leu Glu Arg Ser 
145                 150                 155                 160 

Gly Ile Tyr Ile Val Glu Arg Leu Ile Asn Gly Gln Ala Asp Ala Tyr 
                165                 170                 175     

Ser Ala Trp Ser Lys Leu Gly Arg Pro Tyr Ile Val Leu Gly Thr Asn 
            180                 185                 190         

Lys Ser Ser Val Arg Arg Asn Phe Asp Leu Ala His Glu Leu Gly His 
        195                 200                 205             


Ile Leu Leu His Lys Tyr Lys Asp Met Asn Glu Asp Gly Asp Arg Leu 
    210                 215                 220                 

Glu Gln Glu Ala Asn Tyr Phe Ala Ser Cys Phe Leu Leu Pro Lys Glu 
225                 230                 235                 240 

Glu Phe Leu Val Lys Phe Glu Glu Arg Val Gly Lys Arg Val Ser Asn 
                245                 250                 255     

Pro Asp Ser Tyr Ile Leu Leu Lys Ser Asp Leu Asn Val Ser Ile Gln 
            260                 265                 270         

Ala Leu Glu Tyr Arg Ala Phe Lys Leu Gly Leu Leu Thr Pro Lys Gln 
        275                 280                 285             

His Ser Tyr Phe Tyr Arg Gln Ile Ala Gln Lys Gly Tyr Lys Met Ile 
    290                 295                 300                 

Glu Pro Leu Asp Asp Gln Ile Phe Val Lys Lys Pro Ser Lys Val Lys 
305                 310                 315                 320 

Ser Ile Leu Asp Val Val Leu Ser Asn His Leu Val Ser Leu Ala Thr 
                325                 330                 335     

Ile Met Ser Lys Gln Ser Ile Arg Leu Gln Phe Ile Ser Glu Ile Phe 
            340                 345                 350         

Ser Val Glu Met Lys Phe Phe Asp Gln Tyr Gln Glu Asp Arg Arg Thr 
        355                 360                 365             

Asp Arg Phe Asp Asn Ile Ile Pro Leu Tyr Lys Arg Asn Asn Leu 
    370                 375                 380             

<210>   3741
<211>   729
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3741
atgttgaatc aggatctctt tgattcgctt gaggcacaaa aaattgtaga tactttgatg   60
aaagggcaaa aagattatgt agatgaacgt ctagaaaaaa gagagacaat gatagtgtcg   120
aatggttatg catggacgcg acctaatcat attgatactg catttgcatc agcagatttg   180
tttgagtata aattacaatt agcaggacag acttggggat atttagaatt tgaaacaaat   240
acagaaaaat atgggaaagt attgttaatt ataaagggta agaagcgact tacaaaccaa   300
tttcctttgg tacaaaaaaa taagagtggc tacttatttg aatatgctca gatgaataca   360
ctttatctta atcaacattc ttcctacaaa aatgatgaaa atagtcattc ctttccaatt   420
cagatggagt tagtttctga tgaaatgatt caagaaattg aacaagctac taaaaattcg   480
aatatcgaaa aatttatgat tttaacttat gaggcggact cagaaaacaa tattatatct   540
gtagatgttg ttatgcctga tgcacgaact ggtcagttac acttgattca agatttgtct   600
gagtatattc aatcaagttc gtaccatttc gaagaagcta aatatcaaga tattcctaat   660
ttttcagaat tatcggaaac agaagatttt gaaattattc caagaataga aaaacaagaa   720
ggtcaaaag                                                           729

<210>   3742
<211>   243
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903672 (e-138)

<400>   3742
Met Leu Asn Gln Asp Leu Phe Asp Ser Leu Glu Ala Gln Lys Ile Val 
1               5                   10                  15      

Asp Thr Leu Met Lys Gly Gln Lys Asp Tyr Val Asp Glu Arg Leu Glu 
            20                  25                  30          

Lys Arg Glu Thr Met Ile Val Ser Asn Gly Tyr Ala Trp Thr Arg Pro 
        35                  40                  45              

Asn His Ile Asp Thr Ala Phe Ala Ser Ala Asp Leu Phe Glu Tyr Lys 
    50                  55                  60                  

Leu Gln Leu Ala Gly Gln Thr Trp Gly Tyr Leu Glu Phe Glu Thr Asn 
65                  70                  75                  80  

Thr Glu Lys Tyr Gly Lys Val Leu Leu Ile Ile Lys Gly Lys Lys Arg 
                85                  90                  95      

Leu Thr Asn Gln Phe Pro Leu Val Gln Lys Asn Lys Ser Gly Tyr Leu 
            100                 105                 110         

Phe Glu Tyr Ala Gln Met Asn Thr Leu Tyr Leu Asn Gln His Ser Ser 
        115                 120                 125             

Tyr Lys Asn Asp Glu Asn Ser His Ser Phe Pro Ile Gln Met Glu Leu 
    130                 135                 140                 

Val Ser Asp Glu Met Ile Gln Glu Ile Glu Gln Ala Thr Lys Asn Ser 
145                 150                 155                 160 

Asn Ile Glu Lys Phe Met Ile Leu Thr Tyr Glu Ala Asp Ser Glu Asn 
                165                 170                 175     

Asn Ile Ile Ser Val Asp Val Val Met Pro Asp Ala Arg Thr Gly Gln 
            180                 185                 190         

Leu His Leu Ile Gln Asp Leu Ser Glu Tyr Ile Gln Ser Ser Ser Tyr 
        195                 200                 205             

His Phe Glu Glu Ala Lys Tyr Gln Asp Ile Pro Asn Phe Ser Glu Leu 
    210                 215                 220                 

Ser Glu Thr Glu Asp Phe Glu Ile Ile Pro Arg Ile Glu Lys Gln Glu 
225                 230                 235                 240 

Gly Gln Lys 
            

<210>   3743
<211>   774
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3743
atgcctaaga cactaacaga aaaattaaat gctattaaag cagctggaaa aggaattttt   60
gttccctata tcatggctgg tgaccacgag aaaggtttgg acggtcttgc tgaaacaatt   120
cactttttag aagatttggg tgtctctgca attgaagtgg gtattccctt ttcagaccct   180
gttgcagatg gacctgttat cgaagaagct ggcttgcgca gtttagccca cgggacctct   240
acccaggctt tagttgaaac cttgaaaacc attgaaacag agattccact ggtcatcatg   300
acctacttca accccctctt tcagtacggt gtggagaact ttgtcaaaga tctggctgat   360
acagctgtga agggcttgat tatcccagac ctgcctcatg aacatgccaa ctttgtagaa   420
ccatttttgg caaatacaga tatcgccttg attcctttag taagcttgac cacaggaatt   480
gagcgccaga aagagttgat tgaaggggcg gagggattca tctatgccgt tgccatcaat   540
ggagtgacag ggaaatcagg caattaccgt gcagatttgg acaagcactt ggcgcaactt   600
catcaagtgg ccgacatccc agtcttgaca ggttttggtg tatctagtca agccgatctg   660
gaacgcttca atgcggtgtc agatggtgtt atcgtcggtt cgaaaatagt aaaagctctc   720
caccaaggag agccgattca ggattttatc agacaagcag tagcttacca aaaa         774

<210>   3744
<211>   258
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tryptophan synthase, alpha subunit (trpA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903673 (e-143)

<400>   3744
Met Pro Lys Thr Leu Thr Glu Lys Leu Asn Ala Ile Lys Ala Ala Gly 
1               5                   10                  15      

Lys Gly Ile Phe Val Pro Tyr Ile Met Ala Gly Asp His Glu Lys Gly 
            20                  25                  30          

Leu Asp Gly Leu Ala Glu Thr Ile His Phe Leu Glu Asp Leu Gly Val 
        35                  40                  45              

Ser Ala Ile Glu Val Gly Ile Pro Phe Ser Asp Pro Val Ala Asp Gly 
    50                  55                  60                  

Pro Val Ile Glu Glu Ala Gly Leu Arg Ser Leu Ala His Gly Thr Ser 
65                  70                  75                  80  

Thr Gln Ala Leu Val Glu Thr Leu Lys Thr Ile Glu Thr Glu Ile Pro 
                85                  90                  95      

Leu Val Ile Met Thr Tyr Phe Asn Pro Leu Phe Gln Tyr Gly Val Glu 
            100                 105                 110         

Asn Phe Val Lys Asp Leu Ala Asp Thr Ala Val Lys Gly Leu Ile Ile 
        115                 120                 125             

Pro Asp Leu Pro His Glu His Ala Asn Phe Val Glu Pro Phe Leu Ala 
    130                 135                 140                 

Asn Thr Asp Ile Ala Leu Ile Pro Leu Val Ser Leu Thr Thr Gly Ile 
145                 150                 155                 160 

Glu Arg Gln Lys Glu Leu Ile Glu Gly Ala Glu Gly Phe Ile Tyr Ala 
                165                 170                 175     

Val Ala Ile Asn Gly Val Thr Gly Lys Ser Gly Asn Tyr Arg Ala Asp 
            180                 185                 190         

Leu Asp Lys His Leu Ala Gln Leu His Gln Val Ala Asp Ile Pro Val 
        195                 200                 205             

Leu Thr Gly Phe Gly Val Ser Ser Gln Ala Asp Leu Glu Arg Phe Asn 
    210                 215                 220                 

Ala Val Ser Asp Gly Val Ile Val Gly Ser Lys Ile Val Lys Ala Leu 
225                 230                 235                 240 

His Gln Gly Glu Pro Ile Gln Asp Phe Ile Arg Gln Ala Val Ala Tyr 
                245                 250                 255     

Gln Lys 
        

<210>   3745
<211>   1221
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3745
atggcatatc aggaaccaaa taaagatgga ttttacggaa aattcggcgg acgttttgtc   60
ccagaaacat tgatgacagc agttttggag ttggagaagg cctaccgtga aagtcaggca   120
gacccaagtt tccaagagga attaaaccag cttttgcgcc agtacgtagg acgtgaaact   180
cctctttatt acgcaaaaaa cttgacccag catattggcg gagccaagat ttatctcaaa   240
cgggaagacc ttaaccatac aggagcccac aagattaaca atgccttagg acaagtttgg   300
cttgccaaac gcatgggtaa aaagaaaatt atcgcagaaa cgggtgctgg tcagcacggt   360
gtggcaactg caactgctgc agccctcttt aacatggaat gtaccatcta catgggtgag   420
gaagatgtca aacgccaagc cctcaatgtc ttccgcatgg agcttttggg agccaaggtc   480
gaggctgtaa cagatggttc gcgcgtgctc aaggatgcgg tcaatgcagc ccttcgttca   540
tgggtggcta atatcgacga tacccactat atccttggtt ctgccttggg gcctcatcca   600
tttccagaaa tcgttcgtga cttccaaagt gtcatcggtc gagaggctaa acaacagtac   660
cgtgacttga caggtcgaga tctgccagat gccctagtag cctgtgttgg tggtgggtcg   720
aatgctatcg ggctcttcca tccctttgta gaagatgagt cagtagctat gtatggaact   780
gaagcagcag ggcttggtgt ggatacagag caccacgcag ctaccttgac caagggtcgt   840
ccaggtgtcc ttcacggttc cctcatggat gtgctccaag atgcccatgg tcaaattctt   900
gaagccttct ctatctcagc aggtttggac tatcctggta tcggtccaga gcattctcac   960
taccacgata ttaaacgtgc cagctatgtc cctgtgacag acgaagaagc cttggaagga   1020
ttccaactct tgtctcgtgt ggaagggatt atcccagcct tggaatctag ccatgctatc   1080
gcctttgcgg tgaaattggc caaagaactt ggaccagaaa agtctatgat tgtctgccta   1140
tcaggtcgtg gggacaagga tgtggttcaa gtcaaggacc gcttggaagc agatgcagca   1200
aagaagggag aagctcatgc c                                             1221

<210>   3746
<211>   407
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tryptophan synthase, beta subunit (trpB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903674 (0.E+01)

<400>   3746
Met Ala Tyr Gln Glu Pro Asn Lys Asp Gly Phe Tyr Gly Lys Phe Gly 
1               5                   10                  15      

Gly Arg Phe Val Pro Glu Thr Leu Met Thr Ala Val Leu Glu Leu Glu 
            20                  25                  30          

Lys Ala Tyr Arg Glu Ser Gln Ala Asp Pro Ser Phe Gln Glu Glu Leu 
        35                  40                  45              

Asn Gln Leu Leu Arg Gln Tyr Val Gly Arg Glu Thr Pro Leu Tyr Tyr 
    50                  55                  60                  

Ala Lys Asn Leu Thr Gln His Ile Gly Gly Ala Lys Ile Tyr Leu Lys 
65                  70                  75                  80  

Arg Glu Asp Leu Asn His Thr Gly Ala His Lys Ile Asn Asn Ala Leu 
                85                  90                  95      

Gly Gln Val Trp Leu Ala Lys Arg Met Gly Lys Lys Lys Ile Ile Ala 
            100                 105                 110         

Glu Thr Gly Ala Gly Gln His Gly Val Ala Thr Ala Thr Ala Ala Ala 
        115                 120                 125             

Leu Phe Asn Met Glu Cys Thr Ile Tyr Met Gly Glu Glu Asp Val Lys 
    130                 135                 140                 

Arg Gln Ala Leu Asn Val Phe Arg Met Glu Leu Leu Gly Ala Lys Val 
145                 150                 155                 160 

Glu Ala Val Thr Asp Gly Ser Arg Val Leu Lys Asp Ala Val Asn Ala 
                165                 170                 175     

Ala Leu Arg Ser Trp Val Ala Asn Ile Asp Asp Thr His Tyr Ile Leu 
            180                 185                 190         

Gly Ser Ala Leu Gly Pro His Pro Phe Pro Glu Ile Val Arg Asp Phe 
        195                 200                 205             

Gln Ser Val Ile Gly Arg Glu Ala Lys Gln Gln Tyr Arg Asp Leu Thr 
    210                 215                 220                 

Gly Arg Asp Leu Pro Asp Ala Leu Val Ala Cys Val Gly Gly Gly Ser 
225                 230                 235                 240 

Asn Ala Ile Gly Leu Phe His Pro Phe Val Glu Asp Glu Ser Val Ala 
                245                 250                 255     

Met Tyr Gly Thr Glu Ala Ala Gly Leu Gly Val Asp Thr Glu His His 
            260                 265                 270         

Ala Ala Thr Leu Thr Lys Gly Arg Pro Gly Val Leu His Gly Ser Leu 
        275                 280                 285             

Met Asp Val Leu Gln Asp Ala His Gly Gln Ile Leu Glu Ala Phe Ser 
    290                 295                 300                 

Ile Ser Ala Gly Leu Asp Tyr Pro Gly Ile Gly Pro Glu His Ser His 
305                 310                 315                 320 

Tyr His Asp Ile Lys Arg Ala Ser Tyr Val Pro Val Thr Asp Glu Glu 
                325                 330                 335     

Ala Leu Glu Gly Phe Gln Leu Leu Ser Arg Val Glu Gly Ile Ile Pro 
            340                 345                 350         

Ala Leu Glu Ser Ser His Ala Ile Ala Phe Ala Val Lys Leu Ala Lys 
        355                 360                 365             

Glu Leu Gly Pro Glu Lys Ser Met Ile Val Cys Leu Ser Gly Arg Gly 
    370                 375                 380                 

Asp Lys Asp Val Val Gln Val Lys Asp Arg Leu Glu Ala Asp Ala Ala 
385                 390                 395                 400 

Lys Lys Gly Glu Ala His Ala 
                405         

<210>   3747
<211>   597
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3747
ttgacaaagg ttaaaatttg tggactatcg accaaagaag cggtggaaac agccgtttca   60
gcaggagccg actatatcgg ttttgtcttt gcacctagta aaagacaggt gactttagaa   120
gaggcagctg agttggcaaa gcttattcct gcagatgtga aaaaggttgg agtatttgtt   180
tcaccaagtc gggtagaact gctggaagcg attgacaaag ttggcttgga cttggttcaa   240
gttcacggtc aggtggcaga tgatttattt gagaatttgc cttgtgccag tattcaggct   300
gtgcaggtag atggaaatgg gcatgtcccc aattctcagg cagattatct actctttgat   360
gcccctgtgg caggaagtgg ccagcccttt gattggggtc aactggatac gactggacta   420

gcacagccct tctttatcgc aggtggcctt aatgaagata atgtagtaaa agcaattcaa   480
cactttactc cctatgcagt agatgtatcg agcggagtgg agacagatgg acaaaaagat   540
catgaaaaga ttagaagatt tatagagagg gtaaagcatg gcatatcagg aaccaaa      597

<210>   3748
<211>   199
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   N-(5'-phosphoribosyl)-anthranilate isomerase (trpF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903675 (e-110)

<400>   3748
Met Thr Lys Val Lys Ile Cys Gly Leu Ser Thr Lys Glu Ala Val Glu 
1               5                   10                  15      

Thr Ala Val Ser Ala Gly Ala Asp Tyr Ile Gly Phe Val Phe Ala Pro 
            20                  25                  30          

Ser Lys Arg Gln Val Thr Leu Glu Glu Ala Ala Glu Leu Ala Lys Leu 
        35                  40                  45              

Ile Pro Ala Asp Val Lys Lys Val Gly Val Phe Val Ser Pro Ser Arg 
    50                  55                  60                  

Val Glu Leu Leu Glu Ala Ile Asp Lys Val Gly Leu Asp Leu Val Gln 
65                  70                  75                  80  

Val His Gly Gln Val Ala Asp Asp Leu Phe Glu Asn Leu Pro Cys Ala 
                85                  90                  95      

Ser Ile Gln Ala Val Gln Val Asp Gly Asn Gly His Val Pro Asn Ser 
            100                 105                 110         

Gln Ala Asp Tyr Leu Leu Phe Asp Ala Pro Val Ala Gly Ser Gly Gln 
        115                 120                 125             

Pro Phe Asp Trp Gly Gln Leu Asp Thr Thr Gly Leu Ala Gln Pro Phe 
    130                 135                 140                 

Phe Ile Ala Gly Gly Leu Asn Glu Asp Asn Val Val Lys Ala Ile Gln 
145                 150                 155                 160 

His Phe Thr Pro Tyr Ala Val Asp Val Ser Ser Gly Val Glu Thr Asp 
                165                 170                 175     

Gly Gln Lys Asp His Glu Lys Ile Arg Arg Phe Ile Glu Arg Val Lys 
            180                 185                 190         

His Gly Ile Ser Gly Thr Lys 
        195                 

<210>   3749
<211>   765
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3749
atgagtcagg aatttttagc acgaatctta gagcagaagg cgcgtgaggt ggagcagatg   60
aagctggagc aaatccagcc tctgcgccag acctatcgct tggcagaatt tttgaagaat   120
catcaggacc gcttgcaggt aatcgctgag gtcaagaaag ctagccctag tttgggagat   180
atcaatctcg atgtggatat tgtgcaacag gcccagactt atgaagaaaa cggagcagtg   240
atgatttcgg tgttgacaga tgaggttttc tttaaagggc atttggatta tctacgggaa   300
atttccagtc aggtagagat tccgacgctc aacaaagact ttatcatcga tgaaaagcaa   360
atcatccgcg ctcgcaatgc aggtgcgaca gttatcttgc tcattgtggc agccttgtcc   420
gaagaacgcc tcaaggaact gtatgactac gcgacagagc ttggtctgga agtcttagtg   480
gagactcaca atctagctga actagaggta gcccacagac ttggtgctga gattatcggg   540
gtcaacaacc gcaacttgac tacctttgag gtcgacttgc agaccagtgt agatttagcc   600
ccttactttg aggaaggtcg ctattacatt tctgaatctg ccattttcac agggcaggat   660
gcggaacgac tagccccata ctttaacgga attttggtag ggacagctct tatgcaggca   720
gaaaatgtgg cccagagaat caaggagttg cagattgaca aaggt                   765

<210>   3750
<211>   255
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   indole-3-glycerol phosphate synthase (trpC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903676 (e-138)

<400>   3750
Met Ser Gln Glu Phe Leu Ala Arg Ile Leu Glu Gln Lys Ala Arg Glu 
1               5                   10                  15      

Val Glu Gln Met Lys Leu Glu Gln Ile Gln Pro Leu Arg Gln Thr Tyr 
            20                  25                  30          

Arg Leu Ala Glu Phe Leu Lys Asn His Gln Asp Arg Leu Gln Val Ile 
        35                  40                  45              

Ala Glu Val Lys Lys Ala Ser Pro Ser Leu Gly Asp Ile Asn Leu Asp 
    50                  55                  60                  

Val Asp Ile Val Gln Gln Ala Gln Thr Tyr Glu Glu Asn Gly Ala Val 
65                  70                  75                  80  

Met Ile Ser Val Leu Thr Asp Glu Val Phe Phe Lys Gly His Leu Asp 
                85                  90                  95      

Tyr Leu Arg Glu Ile Ser Ser Gln Val Glu Ile Pro Thr Leu Asn Lys 
            100                 105                 110         

Asp Phe Ile Ile Asp Glu Lys Gln Ile Ile Arg Ala Arg Asn Ala Gly 
        115                 120                 125             

Ala Thr Val Ile Leu Leu Ile Val Ala Ala Leu Ser Glu Glu Arg Leu 
    130                 135                 140                 

Lys Glu Leu Tyr Asp Tyr Ala Thr Glu Leu Gly Leu Glu Val Leu Val 
145                 150                 155                 160 

Glu Thr His Asn Leu Ala Glu Leu Glu Val Ala His Arg Leu Gly Ala 
                165                 170                 175     

Glu Ile Ile Gly Val Asn Asn Arg Asn Leu Thr Thr Phe Glu Val Asp 
            180                 185                 190         

Leu Gln Thr Ser Val Asp Leu Ala Pro Tyr Phe Glu Glu Gly Arg Tyr 
        195                 200                 205             

Tyr Ile Ser Glu Ser Ala Ile Phe Thr Gly Gln Asp Ala Glu Arg Leu 
    210                 215                 220                 

Ala Pro Tyr Phe Asn Gly Ile Leu Val Gly Thr Ala Leu Met Gln Ala 
225                 230                 235                 240 

Glu Asn Val Ala Gln Arg Ile Lys Glu Leu Gln Ile Asp Lys Gly 
                245                 250                 255 

<210>   3751
<211>   1002
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3751
atgaaagaga ttattgaaaa actagcaaaa tttgaaaatt tatcaggtgt ggaaatgacg   60
gatgtcattg agcgtatcgt aactgggcgt gtaactgaag cgcagattgc ttctctcctc   120
ttagctctta agatgaaggg ggaaacacct gaagaacgca cagccattgc ccaagtcatg   180
agaggacatg cccagcatat tccaactgag attcatgatg ccatggacaa ctgtggtaca   240
ggtggggaca agtctttcag ttttaatatt tccacaactg cagcctttgt cttggctggt   300
ggcggtattc acatggccaa acacggtaac cgctcgatat cttctaaatc tggttccgca   360
gatgtcctcg aagccttggg aatcaatctt gacctcaaac cagctgaact aggtaaggtc   420
tttgataaaa ctggaatcgt ctttctcttc gctaaaaata tgcacccagc tatgaaatac   480
atcatgccag ctcgtttgga attgggaatt ccaacgatta tgaacttgac tggtccactg   540
attcatccaa tggctttaga aacacagctt cttggaatta gtcgtccaga actcctagaa   600
agtacagctc aggttttgaa aaatatgggt cgcaaacgtg ccatcgtggt tgctggacca   660
gaagggttgg atgaagctgg cttgaacgga acaaccaaga ttgcacttct tgaaaatggc   720
gaaatcagct tgtcaagctt tactccagag gatttgggaa tggaaggcta tgctatggaa   780
gatattcgtg gtgggaatgc tcaggaaaat gcagaaattt tgcttagcgt tctgaaaaac   840
gaagcaagtc cattcttgga aacgacagtc ttgaatgctg gtcttggttt ctatgctaat   900
ggtaagattg atagcatcaa ggaaggggtt gccttggccc gtcaagtgat tgctagaggc   960
aaggcccttg aaaaactcag actgttacag gagtaccaaa aa                      1002

<210>   3752
<211>   334
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   anthranilate phosphoribosyltransferase (trpD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903677 (0.E+01)

<400>   3752
Met Lys Glu Ile Ile Glu Lys Leu Ala Lys Phe Glu Asn Leu Ser Gly 
1               5                   10                  15      

Val Glu Met Thr Asp Val Ile Glu Arg Ile Val Thr Gly Arg Val Thr 
            20                  25                  30          

Glu Ala Gln Ile Ala Ser Leu Leu Leu Ala Leu Lys Met Lys Gly Glu 
        35                  40                  45              

Thr Pro Glu Glu Arg Thr Ala Ile Ala Gln Val Met Arg Gly His Ala 
    50                  55                  60                  

Gln His Ile Pro Thr Glu Ile His Asp Ala Met Asp Asn Cys Gly Thr 
65                  70                  75                  80  

Gly Gly Asp Lys Ser Phe Ser Phe Asn Ile Ser Thr Thr Ala Ala Phe 
                85                  90                  95      

Val Leu Ala Gly Gly Gly Ile His Met Ala Lys His Gly Asn Arg Ser 
            100                 105                 110         

Ile Ser Ser Lys Ser Gly Ser Ala Asp Val Leu Glu Ala Leu Gly Ile 
        115                 120                 125             

Asn Leu Asp Leu Lys Pro Ala Glu Leu Gly Lys Val Phe Asp Lys Thr 
    130                 135                 140                 

Gly Ile Val Phe Leu Phe Ala Lys Asn Met His Pro Ala Met Lys Tyr 
145                 150                 155                 160 

Ile Met Pro Ala Arg Leu Glu Leu Gly Ile Pro Thr Ile Met Asn Leu 
                165                 170                 175     

Thr Gly Pro Leu Ile His Pro Met Ala Leu Glu Thr Gln Leu Leu Gly 
            180                 185                 190         

Ile Ser Arg Pro Glu Leu Leu Glu Ser Thr Ala Gln Val Leu Lys Asn 
        195                 200                 205             

Met Gly Arg Lys Arg Ala Ile Val Val Ala Gly Pro Glu Gly Leu Asp 
    210                 215                 220                 

Glu Ala Gly Leu Asn Gly Thr Thr Lys Ile Ala Leu Leu Glu Asn Gly 
225                 230                 235                 240 

Glu Ile Ser Leu Ser Ser Phe Thr Pro Glu Asp Leu Gly Met Glu Gly 
                245                 250                 255     

Tyr Ala Met Glu Asp Ile Arg Gly Gly Asn Ala Gln Glu Asn Ala Glu 
            260                 265                 270         

Ile Leu Leu Ser Val Leu Lys Asn Glu Ala Ser Pro Phe Leu Glu Thr 
        275                 280                 285             

Thr Val Leu Asn Ala Gly Leu Gly Phe Tyr Ala Asn Gly Lys Ile Asp 
    290                 295                 300                 

Ser Ile Lys Glu Gly Val Ala Leu Ala Arg Gln Val Ile Ala Arg Gly 
305                 310                 315                 320 

Lys Ala Leu Glu Lys Leu Arg Leu Leu Gln Glu Tyr Gln Lys 
                325                 330                 

<210>   3753
<211>   564
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3753
atgattttat tgattgacaa ctatgattct tttacctata acttggccca atacattggg   60
aattttgcag aagttcaggt tctgagaaat gatgattcca agctgtatga agaagctgaa   120
aaagcagatg gtctggtctt ttctcctggt cctggttggc cagttgatgc tggaaagatg   180
gaagacatga ttcgtgattt tgcaggcaag aagccgattc ttgggatttg tttgggccac   240
caagccattg cagaagtctt tggtggtaag ctaggtttgg ctccaaaagt catgcatggg   300
aaacagagca atatcaactt tgaagcgcca tctgttttgt atcaaggtat tgaggatggc   360
cgtgcggtca tgcgttatca cagtattttg attgaggaaa tgccagaaga ctttgaagtg   420
acagctcgtt cgactgatga ccaagccatc atggggattc aacataaaaa cctaccgatt   480
tatggcttcc agtaccatcc agagagcatt ggaacgccag acggcttgtc ttctattcgg   540
aattttatcg aggaggttgt aaag                                          564

<210>   3754
<211>   188
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   anthranilate synthase component II (trpG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903678 (e-108)

<400>   3754
Met Ile Leu Leu Ile Asp Asn Tyr Asp Ser Phe Thr Tyr Asn Leu Ala 
1               5                   10                  15      

Gln Tyr Ile Gly Asn Phe Ala Glu Val Gln Val Leu Arg Asn Asp Asp 
            20                  25                  30          

Ser Lys Leu Tyr Glu Glu Ala Glu Lys Ala Asp Gly Leu Val Phe Ser 
        35                  40                  45              

Pro Gly Pro Gly Trp Pro Val Asp Ala Gly Lys Met Glu Asp Met Ile 
    50                  55                  60                  

Arg Asp Phe Ala Gly Lys Lys Pro Ile Leu Gly Ile Cys Leu Gly His 
65                  70                  75                  80  

Gln Ala Ile Ala Glu Val Phe Gly Gly Lys Leu Gly Leu Ala Pro Lys 
                85                  90                  95      

Val Met His Gly Lys Gln Ser Asn Ile Asn Phe Glu Ala Pro Ser Val 
            100                 105                 110         

Leu Tyr Gln Gly Ile Glu Asp Gly Arg Ala Val Met Arg Tyr His Ser 
        115                 120                 125             

Ile Leu Ile Glu Glu Met Pro Glu Asp Phe Glu Val Thr Ala Arg Ser 
    130                 135                 140                 

Thr Asp Asp Gln Ala Ile Met Gly Ile Gln His Lys Asn Leu Pro Ile 
145                 150                 155                 160 

Tyr Gly Phe Gln Tyr His Pro Glu Ser Ile Gly Thr Pro Asp Gly Leu 
                165                 170                 175     

Ser Ser Ile Arg Asn Phe Ile Glu Glu Val Val Lys 
            180                 185             

<210>   3755
<211>   1359
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3755
atggaacgaa tcattcatgg agatgtctta tcaccaatct tggcttatat gcgcttaaag   60
gggcaacata aggttatttt agagagtatt ccgagagaca aggaaacagc tcgtttttct   120
atcctagcct ataatccagt ttttgagatt aagtttgaaa atggggttct ctatcaaaat   180
ggtcaagtga ttgatcggga tcccttggat ttcctttatg aagtgattca taagagtcag   240
caccactcag agctaccttt tggtggtgga gccattggtt ttgtgggtta cgatatgatt   300
tcgctttatg aagaaattgg tcaaatccct gaggatacaa ttgggacgcc agacatgcat   360
ttctttgtct atgagagcta tatggtcttt gaccacaaga aggagaagat acatgtcata   420
gaggatgcac tttatagtga gcgcagtcaa gaggccttgg aaaaatcctt gaaccaagtg   480
cttgaggaat tacgcattcc tgctccaaat gaatttgaag atttggatct atctccgtta   540
gacttcaaac cgcatatcgc tccacataag tttgagggaa tggtagaaac agctcgtgac   600
ttgattcgta acggagatat gttccaatgt gtactcagcc agcgtttttc agcagaagtt   660
actggaaatc catttgactt ctacagaaat ctccgcgtga ctaatccttc taattacctt   720
tatttctatg attttgggga ttatcaaatc atcggagcta gtccagaaag tttggtttct   780
gtcaaaaatg gcatcgtgac aaccaatccg attgcaggga cgcgaccaag aggggctacg   840
gatgaagaag acaaggcctt ggcgactgac ctcctctctg atgagaagga aacagcagaa   900
catcgaatgt tggtagactt ggggcgtaac gatattggcc gcatctctga aacgaccagt   960
gtccaagtca ctaagtatat ggaagtggag ctcttccgct acgtcatgca tttgaccagc   1020
gtagtcaagg ggcgtttgct tccagaactc actgccatgg atgccttgaa agcaacgctt   1080
cctgctggaa ccgtttctgg agcaccaaag attcgagcga tgagacgtat ctatgaactg   1140
gaaacggaaa aacggggagt atacgctggg gcaatcggct acttgtctgc gacgggtgat   1200
atggatttgg ccatcgccat ccgaaccatg attctcaaaa atcaaagagc ctatgtgcag   1260
gctggggcag ggattgtcta cgactctatc gcccaaaacg aataccaaga aaccattaac   1320
aaagcaaaat ctatgactag aattggagaa ctaagacca                          1359

<210>   3756
<211>   453
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   anthranilate synthase component I (trpE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903679 (0.E+01)

<400>   3756
Met Glu Arg Ile Ile His Gly Asp Val Leu Ser Pro Ile Leu Ala Tyr 
1               5                   10                  15      

Met Arg Leu Lys Gly Gln His Lys Val Ile Leu Glu Ser Ile Pro Arg 
            20                  25                  30          

Asp Lys Glu Thr Ala Arg Phe Ser Ile Leu Ala Tyr Asn Pro Val Phe 
        35                  40                  45              

Glu Ile Lys Phe Glu Asn Gly Val Leu Tyr Gln Asn Gly Gln Val Ile 
    50                  55                  60                  

Asp Arg Asp Pro Leu Asp Phe Leu Tyr Glu Val Ile His Lys Ser Gln 
65                  70                  75                  80  

His His Ser Glu Leu Pro Phe Gly Gly Gly Ala Ile Gly Phe Val Gly 
                85                  90                  95      

Tyr Asp Met Ile Ser Leu Tyr Glu Glu Ile Gly Gln Ile Pro Glu Asp 
            100                 105                 110         

Thr Ile Gly Thr Pro Asp Met His Phe Phe Val Tyr Glu Ser Tyr Met 
        115                 120                 125             

Val Phe Asp His Lys Lys Glu Lys Ile His Val Ile Glu Asp Ala Leu 
    130                 135                 140                 

Tyr Ser Glu Arg Ser Gln Glu Ala Leu Glu Lys Ser Leu Asn Gln Val 
145                 150                 155                 160 

Leu Glu Glu Leu Arg Ile Pro Ala Pro Asn Glu Phe Glu Asp Leu Asp 
                165                 170                 175     

Leu Ser Pro Leu Asp Phe Lys Pro His Ile Ala Pro His Lys Phe Glu 
            180                 185                 190         

Gly Met Val Glu Thr Ala Arg Asp Leu Ile Arg Asn Gly Asp Met Phe 
        195                 200                 205             

Gln Cys Val Leu Ser Gln Arg Phe Ser Ala Glu Val Thr Gly Asn Pro 
    210                 215                 220                 

Phe Asp Phe Tyr Arg Asn Leu Arg Val Thr Asn Pro Ser Asn Tyr Leu 
225                 230                 235                 240 

Tyr Phe Tyr Asp Phe Gly Asp Tyr Gln Ile Ile Gly Ala Ser Pro Glu 
                245                 250                 255     

Ser Leu Val Ser Val Lys Asn Gly Ile Val Thr Thr Asn Pro Ile Ala 
            260                 265                 270         

Gly Thr Arg Pro Arg Gly Ala Thr Asp Glu Glu Asp Lys Ala Leu Ala 
        275                 280                 285             

Thr Asp Leu Leu Ser Asp Glu Lys Glu Thr Ala Glu His Arg Met Leu 
    290                 295                 300                 

Val Asp Leu Gly Arg Asn Asp Ile Gly Arg Ile Ser Glu Thr Thr Ser 
305                 310                 315                 320 

Val Gln Val Thr Lys Tyr Met Glu Val Glu Leu Phe Arg Tyr Val Met 
                325                 330                 335     

His Leu Thr Ser Val Val Lys Gly Arg Leu Leu Pro Glu Leu Thr Ala 
            340                 345                 350         

Met Asp Ala Leu Lys Ala Thr Leu Pro Ala Gly Thr Val Ser Gly Ala 
        355                 360                 365             

Pro Lys Ile Arg Ala Met Arg Arg Ile Tyr Glu Leu Glu Thr Glu Lys 
    370                 375                 380                 

Arg Gly Val Tyr Ala Gly Ala Ile Gly Tyr Leu Ser Ala Thr Gly Asp 
385                 390                 395                 400 

Met Asp Leu Ala Ile Ala Ile Arg Thr Met Ile Leu Lys Asn Gln Arg 
                405                 410                 415     

Ala Tyr Val Gln Ala Gly Ala Gly Ile Val Tyr Asp Ser Ile Ala Gln 
            420                 425                 430         

Asn Glu Tyr Gln Glu Thr Ile Asn Lys Ala Lys Ser Met Thr Arg Ile 
        435                 440                 445             

Gly Glu Leu Arg Pro 
    450             

<210>   3757
<211>   180
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3757
ttgagaatga tgttttcttc tctcgtttca gatgaaccca actttacagc tttctctgct   60
tgttttcagc aaccacaagc tctctgtgag agaaagaact gtaatttttc catctattat   120
tttttagctt ctagtagtct gcaatcgcag ctaggtcctt gcctccacga ccagagacat   180

<210>   3758
<211>   60
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3758
Met Arg Met Met Phe Ser Ser Leu Val Ser Asp Glu Pro Asn Phe Thr 
1               5                   10                  15      

Ala Phe Ser Ala Cys Phe Gln Gln Pro Gln Ala Leu Cys Glu Arg Lys 
            20                  25                  30          

Asn Cys Asn Phe Ser Ile Tyr Tyr Phe Leu Ala Ser Ser Ser Leu Gln 
        35                  40                  45              

Ser Gln Leu Gly Pro Cys Leu His Asp Gln Arg His 
    50                  55                  60  

<210>   3759
<211>   294
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3759
atgaaaatca aagagcaaac taggaaacta gccgcaggct gctcaaaaca ctgttttgag   60
gttgtggata gaactgacga agtcagctca aaacactgtt ttgaggttgt ggatagaact   120
gacgaagtca gctcaaaaca ctgttttgag gttgtggata gaactgacga agtcagctca   180
aaacactgtt ttgaggttgc agatagaact gacgaagtca gtaaccatac ctacggcaag   240
gcgacgttga cgcggtttga agagattttc gaagagtata aaggtgtacc gaga         294

<210>   3760
<211>   98
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3760
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys 
        35                  40                  45              

Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys Phe 
    50                  55                  60                  

Glu Val Ala Asp Arg Thr Asp Glu Val Ser Asn His Thr Tyr Gly Lys 
65                  70                  75                  80  

Ala Thr Leu Thr Arg Phe Glu Glu Ile Phe Glu Glu Tyr Lys Gly Val 
                85                  90                  95      

Pro Arg 
        

<210>   3761
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3761
ttgatgaact tgagttctat ctacagctcc atgcctacta ctaaaagcaa acaaaaaggc   60
tggactaata cgaaaaaagc tagtaatact caa                                93

<210>   3762
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3762
Met Met Asn Leu Ser Ser Ile Tyr Ser Ser Met Pro Thr Thr Lys Ser 
1               5                   10                  15      

Lys Gln Lys Gly Trp Thr Asn Thr Lys Lys Ala Ser Asn Thr Gln 
            20                  25                  30      

<210>   3763
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3763

gtggcaccgc gttaccaacg ccctcacacg gaagtatatt ctgtgtgtgg gcttttttct   60
atccgtcgtt tggtttatct tttattaggg cct                                93

<210>   3764
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3764
Met Ala Pro Arg Tyr Gln Arg Pro His Thr Glu Val Tyr Ser Val Cys 
1               5                   10                  15      

Gly Leu Phe Ser Ile Arg Arg Leu Val Tyr Leu Leu Leu Gly Pro 
            20                  25                  30      

<210>   3765
<211>   999
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3765
atgaaaaata taaatgggaa aaaggtaact atttatgata ttgcacgttt atcaggtttt   60
tctccaaaaa cagtttcacg agttattaat ggtggagtaa atgttaaaga agaaacttat   120
caagcgattc aaaaagttat agaggaattg tcgtatattc caaatgcgta tgcaaaaaat   180
ttaactaaaa aagaagctat aaatatattg atttctgtaa aaaaaatcga ctcttttcct   240
ttaatttggt ttcatacgct gttagataaa gtgttacgga cgtgtaaaga atttggtgtt   300
aatgctatag ttgagtactt tggagaggag gatacaatta gtaattcaat tatatcaagc   360
acaggtagcc tagtagatgg tgttattgtt ttttatgaaa gtgtagatga tatcagaatt   420
cagtatttaa agaagaacca tatgcctttt cttgttttcg gtgaatctca aacgtctgga   480
gtagtctatg tatctaataa taattttcaa gctacttatg atatgatgaa agctgtaact   540

gaagaaaaat ttaaaaatat gtggttgctt atgggaggag aatcccatgt taataaggat   600
cgtgaaagag gtgtgcgttc ttttctgaat gataaaaatt actttatgga tttaaaagtc   660
atttatggct tatctacaat tgattcagtt tattcttatg caatgcagca cttgactacc   720
caaaattatc cggacattat ttttgtttca ggagatgaaa aggttcaggg cttgattcgt   780
gcgtgctatg agaaaggaat tcttattcca gatgatattt ctatcattgg atttgataat   840
attcctattt ctcagtatta tactccagct ttgtctacaa ttgctcccaa ttatgttaaa   900
ttggctaaag aaatgataga aggtgtttta gcaattatta aaggggaaag tgtcacatct   960
gttgaagttt ctcctaaatt tgttaggaga cagagtttc                          999

<210>   3766
<211>   333
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar-binding transcriptional regulator, LacI family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903681 (0.E+01)

<400>   3766
Met Lys Asn Ile Asn Gly Lys Lys Val Thr Ile Tyr Asp Ile Ala Arg 
1               5                   10                  15      

Leu Ser Gly Phe Ser Pro Lys Thr Val Ser Arg Val Ile Asn Gly Gly 
            20                  25                  30          

Val Asn Val Lys Glu Glu Thr Tyr Gln Ala Ile Gln Lys Val Ile Glu 
        35                  40                  45              

Glu Leu Ser Tyr Ile Pro Asn Ala Tyr Ala Lys Asn Leu Thr Lys Lys 
    50                  55                  60                  

Glu Ala Ile Asn Ile Leu Ile Ser Val Lys Lys Ile Asp Ser Phe Pro 
65                  70                  75                  80  

Leu Ile Trp Phe His Thr Leu Leu Asp Lys Val Leu Arg Thr Cys Lys 
                85                  90                  95      

Glu Phe Gly Val Asn Ala Ile Val Glu Tyr Phe Gly Glu Glu Asp Thr 
            100                 105                 110         

Ile Ser Asn Ser Ile Ile Ser Ser Thr Gly Ser Leu Val Asp Gly Val 
        115                 120                 125             

Ile Val Phe Tyr Glu Ser Val Asp Asp Ile Arg Ile Gln Tyr Leu Lys 
    130                 135                 140                 

Lys Asn His Met Pro Phe Leu Val Phe Gly Glu Ser Gln Thr Ser Gly 
145                 150                 155                 160 

Val Val Tyr Val Ser Asn Asn Asn Phe Gln Ala Thr Tyr Asp Met Met 
                165                 170                 175     

Lys Ala Val Thr Glu Glu Lys Phe Lys Asn Met Trp Leu Leu Met Gly 
            180                 185                 190         

Gly Glu Ser His Val Asn Lys Asp Arg Glu Arg Gly Val Arg Ser Phe 
        195                 200                 205             

Leu Asn Asp Lys Asn Tyr Phe Met Asp Leu Lys Val Ile Tyr Gly Leu 
    210                 215                 220                 

Ser Thr Ile Asp Ser Val Tyr Ser Tyr Ala Met Gln His Leu Thr Thr 
225                 230                 235                 240 

Gln Asn Tyr Pro Asp Ile Ile Phe Val Ser Gly Asp Glu Lys Val Gln 
                245                 250                 255     

Gly Leu Ile Arg Ala Cys Tyr Glu Lys Gly Ile Leu Ile Pro Asp Asp 
            260                 265                 270         

Ile Ser Ile Ile Gly Phe Asp Asn Ile Pro Ile Ser Gln Tyr Tyr Thr 
        275                 280                 285             

Pro Ala Leu Ser Thr Ile Ala Pro Asn Tyr Val Lys Leu Ala Lys Glu 
    290                 295                 300                 

Met Ile Glu Gly Val Leu Ala Ile Ile Lys Gly Glu Ser Val Thr Ser 
305                 310                 315                 320 

Val Glu Val Ser Pro Lys Phe Val Arg Arg Gln Ser Phe 
                325                 330             

<210>   3767
<211>   366
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3767
atgaaagatt ataaaatcaa ttttgattta ggtaaaatag aatattttga taataattgt   60
ttgatacaag tatacaaatt tatttctttt tatgatattt gtgaaatggt gtttgccttt   120
catttacctc ctgatgagtt gataacaaat gttatcttta aagaaaaaat taactctatg   180
ttaaaatgtt acattgacag gctattatat gtttttataa atcctacaca ttttactgaa   240
aaagttaatc tacaatttta tggcagtttt ttctcatatg aatttatttg tcgtgaagtt   300
ggaaacattc ttaaaaataa aggtgtgaaa tgcaatttaa acttttttga aggggaagaa   360
tatttg                                                              366

<210>   3768
<211>   122
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903682 (3.E-71)

<400>   3768
Met Lys Asp Tyr Lys Ile Asn Phe Asp Leu Gly Lys Ile Glu Tyr Phe 
1               5                   10                  15      

Asp Asn Asn Cys Leu Ile Gln Val Tyr Lys Phe Ile Ser Phe Tyr Asp 
            20                  25                  30          

Ile Cys Glu Met Val Phe Ala Phe His Leu Pro Pro Asp Glu Leu Ile 
        35                  40                  45              

Thr Asn Val Ile Phe Lys Glu Lys Ile Asn Ser Met Leu Lys Cys Tyr 
    50                  55                  60                  

Ile Asp Arg Leu Leu Tyr Val Phe Ile Asn Pro Thr His Phe Thr Glu 
65                  70                  75                  80  

Lys Val Asn Leu Gln Phe Tyr Gly Ser Phe Phe Ser Tyr Glu Phe Ile 
                85                  90                  95      

Cys Arg Glu Val Gly Asn Ile Leu Lys Asn Lys Gly Val Lys Cys Asn 
            100                 105                 110         

Leu Asn Phe Phe Glu Gly Glu Glu Tyr Leu 
        115                 120         

<210>   3769
<211>   708
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3769
atgacagcca ctagtcttgg gttatcaaat attgaaatag ttgtcaggat tgttttatca   60
gtagtcattg gtagtataat tggtttagag agagggagca aatcccagcc tgcaggcatc   120
cgaacttata gtattgtttg tctagctgca tgtttgatta tgatgacgaa tgaatacgta   180
tcttataaat ttgggacagg agatcctaca cgattaggag ctcaagttat atcaggtgtg   240
ggttttctag gcgctggaac gattcttatt acagataaaa agaaaattac aggtctgaca   300
actgcagcag gcatttgggc ttcggcagga attggattag ctattggagt aggtttttat   360
gagggagctc ttttagtagc catttctgtt tggggtgtga tatccatgtt ccaaccacta   420
aaaaaatatc tgcaaaatcg ttctaaaatg attgaattgt atatagtggt taaatctaca   480
gaagcctata atcgtgtatt ggtttattgt gcagaaaatg gtatcagaat gaccgattca   540
agaacagcgt ttggagatgt taattctgac agaattgaat actttgatgt tccggacaaa   600
aaaatagcgt catttattac tctggaatta tcaggtagat ttgaacatct tcgactgatg   660
gaagaaattg ctaatattgt aggtgttatt tatgtcgaag aaattagc                708

<210>   3770
<211>   236
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MgtC/SapB family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903683 (e-130)

<400>   3770
Met Thr Ala Thr Ser Leu Gly Leu Ser Asn Ile Glu Ile Val Val Arg 
1               5                   10                  15      

Ile Val Leu Ser Val Val Ile Gly Ser Ile Ile Gly Leu Glu Arg Gly 
            20                  25                  30          

Ser Lys Ser Gln Pro Ala Gly Ile Arg Thr Tyr Ser Ile Val Cys Leu 
        35                  40                  45              

Ala Ala Cys Leu Ile Met Met Thr Asn Glu Tyr Val Ser Tyr Lys Phe 
    50                  55                  60                  

Gly Thr Gly Asp Pro Thr Arg Leu Gly Ala Gln Val Ile Ser Gly Val 
65                  70                  75                  80  

Gly Phe Leu Gly Ala Gly Thr Ile Leu Ile Thr Asp Lys Lys Lys Ile 
                85                  90                  95      

Thr Gly Leu Thr Thr Ala Ala Gly Ile Trp Ala Ser Ala Gly Ile Gly 
            100                 105                 110         

Leu Ala Ile Gly Val Gly Phe Tyr Glu Gly Ala Leu Leu Val Ala Ile 
        115                 120                 125             

Ser Val Trp Gly Val Ile Ser Met Phe Gln Pro Leu Lys Lys Tyr Leu 
    130                 135                 140                 

Gln Asn Arg Ser Lys Met Ile Glu Leu Tyr Ile Val Val Lys Ser Thr 
145                 150                 155                 160 

Glu Ala Tyr Asn Arg Val Leu Val Tyr Cys Ala Glu Asn Gly Ile Arg 
                165                 170                 175     

Met Thr Asp Ser Arg Thr Ala Phe Gly Asp Val Asn Ser Asp Arg Ile 

            180                 185                 190         

Glu Tyr Phe Asp Val Pro Asp Lys Lys Ile Ala Ser Phe Ile Thr Leu 
        195                 200                 205             

Glu Leu Ser Gly Arg Phe Glu His Leu Arg Leu Met Glu Glu Ile Ala 
    210                 215                 220                 

Asn Ile Val Gly Val Ile Tyr Val Glu Glu Ile Ser 
225                 230                 235     

<210>   3771
<211>   153
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   3771
atgcctgcag gctgggattt gctccctctc tctaaaccaa ttatactacc aatgactact   60
gataaaacaa tcctgacaac tatttcaata tttgataacc caagactagt ggctgtcatg   120
attatttcct tactttacgc cccggtcttt gtg                                153

<210>   3772
<211>   51
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3772
Met Pro Ala Gly Trp Asp Leu Leu Pro Leu Ser Lys Pro Ile Ile Leu 
1               5                   10                  15      

Pro Met Thr Thr Asp Lys Thr Ile Leu Thr Thr Ile Ser Ile Phe Asp 
            20                  25                  30          

Asn Pro Arg Leu Val Ala Val Met Ile Ile Ser Leu Leu Tyr Ala Pro 
        35                  40                  45              

Val Phe Val 
    50      

<210>   3773
<211>   1689
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3773
atgcgtcata aattaaattt aaaagattgg cttattcgtt tagggttaat ctggttctta   60
gtaacattta ttatttatcc aaactttgat ctagtagtga atgtatttgt aaaaggagga   120
gaattttccc ttgatgctgt acatcgtgtt ctaaaatctc agagggcact tcagagtatt   180
atgaacagtt ttaagttagc attttcactc attattacag ttaatgtcgt aggtattctt   240
tgtgttctat ttacagagta ctttgatatt aaaggtgcta aaattttaaa attaggttat   300
atgacctctt taatttatgg aggagtggtt ttagcgactg gatataaatt tgtctatggt   360
ccttatggat tgattacaaa atttttacaa aatgttatcc cttctttaga ccctaactgg   420
tttattgggt atggtgcagt cttattcatt atgacatttt caggaactgc taatcataca   480
ttgtttttaa caaatacaat tcgaagcgtt gactatcaca ctattgaggc tgctcgaaat   540
atgggagcaa aaccatttac tgttttccga aaagtagtgt taccaacctt aattccaact   600
ctatttgcac ttactattat ggtttttctt agtggtttat ctgcagtagc agcacccatg   660
attgttggtg gtaaagaatt tcaaactata aatccaatga ttattacatt tgcagggatg   720
gggaattctc gtgatttagc tgccctactt gcaattattt taggtattgc aactacaatt   780
ttgcttacta tcatgaataa gatagaaaaa ggtggaaatt atatttctat ctctaagact   840
aaagcgcctc ttaaaaaaca aaaaattgcg tctaagcctt ggaatatcat tgctcacatt   900
gtagcatatg gattgttcac agttttcatg cttccactaa tttttatagt attatactca   960
tttacagatc cagttgcaat tcaaacaggt aacttaacat tatcaaactt tactttagaa   1020
aattatcgct tattctttag taatagtgcg gcattctctc cattcttggt cagctttatt   1080
tattctatta ttgctgcgac aacagcaaca attctcgcag ttgtatttgc tcgtgttgtc   1140
agaaaacata aatctcgttt tgatttctta tttgaatatg gtgctctact tccttggtta   1200
ctaccaagta cacttttagc agtaagttta ttatttactt ttaatcagcc acaatttctt   1260
gtcttgaatc agattttggt aggtagtttg gtaattctac ttattgcata tatagttgta   1320
aaaatcccat tttcttatag aatggtacgt gctattttat ttagtgttga tgatgagatg   1380
gaagatgcag caagaagtat gggtgcttca cctttttata ctatgatgaa ggttatcatt   1440
ccatttattt taccggttgt tctctctgtt attgctttaa actttaactc tttattaact   1500
gacttcgact tatctgtatt cctttaccat cccctagctc aaccattagg tattacgatt   1560
cgatctgcag gtgatgaaac agcaacatct aatgcacaag ctctggtatt tgtttataca   1620
attgttctga tgattatttc tggaacggta ttatacttca cacaaagacc ggggcgtaaa   1680
gtaaggaaa                                                           1689

<210>   3774
<211>   563
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903685 (0.E+01)

<400>   3774
Met Arg His Lys Leu Asn Leu Lys Asp Trp Leu Ile Arg Leu Gly Leu 
1               5                   10                  15      

Ile Trp Phe Leu Val Thr Phe Ile Ile Tyr Pro Asn Phe Asp Leu Val 
            20                  25                  30          

Val Asn Val Phe Val Lys Gly Gly Glu Phe Ser Leu Asp Ala Val His 
        35                  40                  45              

Arg Val Leu Lys Ser Gln Arg Ala Leu Gln Ser Ile Met Asn Ser Phe 
    50                  55                  60                  

Lys Leu Ala Phe Ser Leu Ile Ile Thr Val Asn Val Val Gly Ile Leu 
65                  70                  75                  80  

Cys Val Leu Phe Thr Glu Tyr Phe Asp Ile Lys Gly Ala Lys Ile Leu 
                85                  90                  95      

Lys Leu Gly Tyr Met Thr Ser Leu Ile Tyr Gly Gly Val Val Leu Ala 
            100                 105                 110         


Thr Gly Tyr Lys Phe Val Tyr Gly Pro Tyr Gly Leu Ile Thr Lys Phe 
        115                 120                 125             

Leu Gln Asn Val Ile Pro Ser Leu Asp Pro Asn Trp Phe Ile Gly Tyr 
    130                 135                 140                 

Gly Ala Val Leu Phe Ile Met Thr Phe Ser Gly Thr Ala Asn His Thr 
145                 150                 155                 160 

Leu Phe Leu Thr Asn Thr Ile Arg Ser Val Asp Tyr His Thr Ile Glu 
                165                 170                 175     

Ala Ala Arg Asn Met Gly Ala Lys Pro Phe Thr Val Phe Arg Lys Val 
            180                 185                 190         

Val Leu Pro Thr Leu Ile Pro Thr Leu Phe Ala Leu Thr Ile Met Val 
        195                 200                 205             

Phe Leu Ser Gly Leu Ser Ala Val Ala Ala Pro Met Ile Val Gly Gly 
    210                 215                 220                 

Lys Glu Phe Gln Thr Ile Asn Pro Met Ile Ile Thr Phe Ala Gly Met 
225                 230                 235                 240 

Gly Asn Ser Arg Asp Leu Ala Ala Leu Leu Ala Ile Ile Leu Gly Ile 
                245                 250                 255     

Ala Thr Thr Ile Leu Leu Thr Ile Met Asn Lys Ile Glu Lys Gly Gly 
            260                 265                 270         

Asn Tyr Ile Ser Ile Ser Lys Thr Lys Ala Pro Leu Lys Lys Gln Lys 
        275                 280                 285             

Ile Ala Ser Lys Pro Trp Asn Ile Ile Ala His Ile Val Ala Tyr Gly 
    290                 295                 300                 

Leu Phe Thr Val Phe Met Leu Pro Leu Ile Phe Ile Val Leu Tyr Ser 
305                 310                 315                 320 

Phe Thr Asp Pro Val Ala Ile Gln Thr Gly Asn Leu Thr Leu Ser Asn 
                325                 330                 335     

Phe Thr Leu Glu Asn Tyr Arg Leu Phe Phe Ser Asn Ser Ala Ala Phe 
            340                 345                 350         

Ser Pro Phe Leu Val Ser Phe Ile Tyr Ser Ile Ile Ala Ala Thr Thr 
        355                 360                 365             

Ala Thr Ile Leu Ala Val Val Phe Ala Arg Val Val Arg Lys His Lys 
    370                 375                 380                 

Ser Arg Phe Asp Phe Leu Phe Glu Tyr Gly Ala Leu Leu Pro Trp Leu 
385                 390                 395                 400 

Leu Pro Ser Thr Leu Leu Ala Val Ser Leu Leu Phe Thr Phe Asn Gln 
                405                 410                 415     

Pro Gln Phe Leu Val Leu Asn Gln Ile Leu Val Gly Ser Leu Val Ile 
            420                 425                 430         

Leu Leu Ile Ala Tyr Ile Val Val Lys Ile Pro Phe Ser Tyr Arg Met 
        435                 440                 445             


Val Arg Ala Ile Leu Phe Ser Val Asp Asp Glu Met Glu Asp Ala Ala 
    450                 455                 460                 

Arg Ser Met Gly Ala Ser Pro Phe Tyr Thr Met Met Lys Val Ile Ile 
465                 470                 475                 480 

Pro Phe Ile Leu Pro Val Val Leu Ser Val Ile Ala Leu Asn Phe Asn 
                485                 490                 495     

Ser Leu Leu Thr Asp Phe Asp Leu Ser Val Phe Leu Tyr His Pro Leu 
            500                 505                 510         

Ala Gln Pro Leu Gly Ile Thr Ile Arg Ser Ala Gly Asp Glu Thr Ala 
        515                 520                 525             

Thr Ser Asn Ala Gln Ala Leu Val Phe Val Tyr Thr Ile Val Leu Met 
    530                 535                 540                 

Ile Ile Ser Gly Thr Val Leu Tyr Phe Thr Gln Arg Pro Gly Arg Lys 
545                 550                 555                 560 

Val Arg Lys 
            

<210>   3775
<211>   1008
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3775
atgattaaat ttgataatat tcaaattaaa tatggtgatt ttgttgcaat tgataatctg   60
aatttagata tacatgaagg ggaatttttt acatttcttg ggccttcagg atgtggtaaa   120
tcaactactt tgagagcatt ggtaggtttt ctagatccat catcaggaag tattgaagtt   180
aatggaacag atgtcactca tttggaacct gaaaagcgtg gaattggtat tgtatttcaa   240
tcttatgcgc tatttccaac tatgactgtt tttgataata ttgcatttgg tttaaaagtt   300
aagaaggtag ctccagatgt tattaaagct aaagtatcag cagtggcagc aaaaattaag   360
atctctgatc aacagttaca gcgtaatgta tcagaattat ctgggggtca acaacaaagg   420
gtagcattgg ctcgtgctct ggttcttgaa cctaaaattc tttgtctaga tgaaccattg   480
tcaaaccttg acgcaaaatt acgtgtagat ttgagaaaag agttgaaaag acttcaaaaa   540
gagttaggta ttactacttt atatgttact catgatcaag aggaagcctt gactttatct   600
gatagaattg cagtctttaa caatggatac atcgaacagg tcggtacacc agtagagatt   660
tatcataatt ctcaaactga atttgtatgt gattttattg gagatattaa tgttttgacc   720
gatgaaacag tccacgaagt attattgaaa aatacaagcg ttttcttaga ggataaaaaa   780
ggatacattc gattagagaa agttcgattc aatcgtgaaa ctgaacaaga ttttattcta   840
aaagggacaa ttattgatgt tgagttttct ggagttacaa ttcactatac aataaaagtt   900
tctgaaagtc agattcttaa tgtaacaagt attgatagtc aggctgctat tagatctgtc   960
ggagaaagtg tggaattatt tatcacacca tcagacgttc tgcaattt                1008

<210>   3776
<211>   336
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903686 (0.E+01)

<400>   3776
Met Ile Lys Phe Asp Asn Ile Gln Ile Lys Tyr Gly Asp Phe Val Ala 
1               5                   10                  15      

Ile Asp Asn Leu Asn Leu Asp Ile His Glu Gly Glu Phe Phe Thr Phe 
            20                  25                  30          

Leu Gly Pro Ser Gly Cys Gly Lys Ser Thr Thr Leu Arg Ala Leu Val 
        35                  40                  45              

Gly Phe Leu Asp Pro Ser Ser Gly Ser Ile Glu Val Asn Gly Thr Asp 
    50                  55                  60                  

Val Thr His Leu Glu Pro Glu Lys Arg Gly Ile Gly Ile Val Phe Gln 
65                  70                  75                  80  

Ser Tyr Ala Leu Phe Pro Thr Met Thr Val Phe Asp Asn Ile Ala Phe 
                85                  90                  95      

Gly Leu Lys Val Lys Lys Val Ala Pro Asp Val Ile Lys Ala Lys Val 
            100                 105                 110         

Ser Ala Val Ala Ala Lys Ile Lys Ile Ser Asp Gln Gln Leu Gln Arg 
        115                 120                 125             

Asn Val Ser Glu Leu Ser Gly Gly Gln Gln Gln Arg Val Ala Leu Ala 
    130                 135                 140                 

Arg Ala Leu Val Leu Glu Pro Lys Ile Leu Cys Leu Asp Glu Pro Leu 
145                 150                 155                 160 

Ser Asn Leu Asp Ala Lys Leu Arg Val Asp Leu Arg Lys Glu Leu Lys 
                165                 170                 175     

Arg Leu Gln Lys Glu Leu Gly Ile Thr Thr Leu Tyr Val Thr His Asp 
            180                 185                 190         

Gln Glu Glu Ala Leu Thr Leu Ser Asp Arg Ile Ala Val Phe Asn Asn 
        195                 200                 205             

Gly Tyr Ile Glu Gln Val Gly Thr Pro Val Glu Ile Tyr His Asn Ser 
    210                 215                 220                 

Gln Thr Glu Phe Val Cys Asp Phe Ile Gly Asp Ile Asn Val Leu Thr 
225                 230                 235                 240 

Asp Glu Thr Val His Glu Val Leu Leu Lys Asn Thr Ser Val Phe Leu 
                245                 250                 255     

Glu Asp Lys Lys Gly Tyr Ile Arg Leu Glu Lys Val Arg Phe Asn Arg 
            260                 265                 270         

Glu Thr Glu Gln Asp Phe Ile Leu Lys Gly Thr Ile Ile Asp Val Glu 
        275                 280                 285             

Phe Ser Gly Val Thr Ile His Tyr Thr Ile Lys Val Ser Glu Ser Gln 
    290                 295                 300                 

Ile Leu Asn Val Thr Ser Ile Asp Ser Gln Ala Ala Ile Arg Ser Val 
305                 310                 315                 320 

Gly Glu Ser Val Glu Leu Phe Ile Thr Pro Ser Asp Val Leu Gln Phe 
                325                 330                 335     


<210>   3777
<211>   1065
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3777
atgaaaaaaa tgaaagtttg gtctactgta cttgcaacgg gagttgctct tactacactt   60
gctgcttgct ctggaggttc aaattctacg actgcttctt catctgaaga aaaagctgat   120
aaaagtcaag aattagttat ctattcgaac tcagtctcaa atggtcgtgg tgattggtta   180
actgctaaag caaaagaagc tggttttaat ataaaaatgg ttgatatcgc tggcgctcaa   240
ttagcagacc gtgttattgc tgagaagaat aatgcagttg cagatatggt atttggaatt   300
ggtgctgttg attcaaataa aattagagat caaaaattac tagtacagta caagcctaaa   360
tggttagata aaattgatca atctttatca gataaagata attattataa tcctgtgatt   420
gttcaaccat tagttttaat tggggcgcct gatgtaaaag aaatgcctaa agattggact   480
gaattaggta gtaagtataa aggtaaatat tcaatttctg gtcttcaagg aggtacagga   540
cgggcaattc tagcaagtat cttagttcga taccttgatg ataaaggtga attaggtgtt   600
tccgaaaaag gttgggaagt agcaaaagaa tatttgaaaa atgcatacac tcttcaaaag   660
ggagaaagtt caattgttaa gatgttagac aaagaagatc caatacaata tggaatgatg   720
tggggttctg gtgcattagt tggacaaaaa gaacaaaatg ttgttttcaa agttatgact   780
cctgagattg gtgtaccatt tgtaactgaa caaactatgg ttttaagcac tagtaaaaaa   840
caagcgttag ctaaagaatt tattgattgg tttggtcaat cagaaattca agtagaatat   900
agtaagaact ttggatctat tcctgcaaat aaagatgccc tcaaagatct acctgaagat   960
acgaagaaat ttgttgatca agtgaaacca caaaatattg actgggaagc tgttggaaag   1020
catttggatg aatgggtaga aaaagctgaa ttagaatacg tacaa                   1065

<210>   3778
<211>   355
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, substrate-binding protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903687 (0.E+01)

<400>   3778
Met Lys Lys Met Lys Val Trp Ser Thr Val Leu Ala Thr Gly Val Ala 
1               5                   10                  15      

Leu Thr Thr Leu Ala Ala Cys Ser Gly Gly Ser Asn Ser Thr Thr Ala 
            20                  25                  30          

Ser Ser Ser Glu Glu Lys Ala Asp Lys Ser Gln Glu Leu Val Ile Tyr 
        35                  40                  45              

Ser Asn Ser Val Ser Asn Gly Arg Gly Asp Trp Leu Thr Ala Lys Ala 
    50                  55                  60                  

Lys Glu Ala Gly Phe Asn Ile Lys Met Val Asp Ile Ala Gly Ala Gln 

65                  70                  75                  80  

Leu Ala Asp Arg Val Ile Ala Glu Lys Asn Asn Ala Val Ala Asp Met 
                85                  90                  95      

Val Phe Gly Ile Gly Ala Val Asp Ser Asn Lys Ile Arg Asp Gln Lys 
            100                 105                 110         

Leu Leu Val Gln Tyr Lys Pro Lys Trp Leu Asp Lys Ile Asp Gln Ser 
        115                 120                 125             

Leu Ser Asp Lys Asp Asn Tyr Tyr Asn Pro Val Ile Val Gln Pro Leu 
    130                 135                 140                 

Val Leu Ile Gly Ala Pro Asp Val Lys Glu Met Pro Lys Asp Trp Thr 
145                 150                 155                 160 

Glu Leu Gly Ser Lys Tyr Lys Gly Lys Tyr Ser Ile Ser Gly Leu Gln 
                165                 170                 175     

Gly Gly Thr Gly Arg Ala Ile Leu Ala Ser Ile Leu Val Arg Tyr Leu 
            180                 185                 190         

Asp Asp Lys Gly Glu Leu Gly Val Ser Glu Lys Gly Trp Glu Val Ala 
        195                 200                 205             

Lys Glu Tyr Leu Lys Asn Ala Tyr Thr Leu Gln Lys Gly Glu Ser Ser 
    210                 215                 220                 

Ile Val Lys Met Leu Asp Lys Glu Asp Pro Ile Gln Tyr Gly Met Met 
225                 230                 235                 240 

Trp Gly Ser Gly Ala Leu Val Gly Gln Lys Glu Gln Asn Val Val Phe 
                245                 250                 255     

Lys Val Met Thr Pro Glu Ile Gly Val Pro Phe Val Thr Glu Gln Thr 
            260                 265                 270         

Met Val Leu Ser Thr Ser Lys Lys Gln Ala Leu Ala Lys Glu Phe Ile 
        275                 280                 285             

Asp Trp Phe Gly Gln Ser Glu Ile Gln Val Glu Tyr Ser Lys Asn Phe 
    290                 295                 300                 

Gly Ser Ile Pro Ala Asn Lys Asp Ala Leu Lys Asp Leu Pro Glu Asp 
305                 310                 315                 320 

Thr Lys Lys Phe Val Asp Gln Val Lys Pro Gln Asn Ile Asp Trp Glu 
                325                 330                 335     

Ala Val Gly Lys His Leu Asp Glu Trp Val Glu Lys Ala Glu Leu Glu 
            340                 345                 350         

Tyr Val Gln 
        355 

<210>   3779
<211>   657
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3779
atgaaaaact taacaaaaat taagttcaaa gagaatgggg aatttaatca tttccctggg   60
aatacagttg tagcaaatct ttatactaaa caagatttga tggaagttgt tgatattatt   120
caatcacgtt atagagaatt accatttatc gataagttta ctttaactcc aaggaattct   180
attcacatga ctgtaattga attgttgtgc catgaaaatc gtgaaacgga gttttggagc   240
agtaatcttc ctctagatac acctttacag gaaatacatg attactttgc taaacaactt   300
gaaatttttc cattgttgga tgaagaaatt catatgcgta taactgaaat gggaaaacaa   360
aacatactag ttgaacctgc agatgaagct tctgcaaaga gattagaaga aattcgtact   420
tatgtctcag aaaaagcagg tgtttgtttc cctaatcatg atagatatca attccatatt   480
tcaattgggt atcttcggat tcctctaacc gaagaggagg aagaagagtt tactaaagtc   540
agagcagaat taactgaaat tttattagag aagattccaa ctattactgt aaaccgtatt   600
gactatactg tatttgaaga tatgagacaa tttgttccat atcacgaaaa atttaaa      657

<210>   3780
<211>   219
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903688 (e-127)

<400>   3780
Met Lys Asn Leu Thr Lys Ile Lys Phe Lys Glu Asn Gly Glu Phe Asn 
1               5                   10                  15      

His Phe Pro Gly Asn Thr Val Val Ala Asn Leu Tyr Thr Lys Gln Asp 
            20                  25                  30          

Leu Met Glu Val Val Asp Ile Ile Gln Ser Arg Tyr Arg Glu Leu Pro 
        35                  40                  45              

Phe Ile Asp Lys Phe Thr Leu Thr Pro Arg Asn Ser Ile His Met Thr 
    50                  55                  60                  

Val Ile Glu Leu Leu Cys His Glu Asn Arg Glu Thr Glu Phe Trp Ser 
65                  70                  75                  80  

Ser Asn Leu Pro Leu Asp Thr Pro Leu Gln Glu Ile His Asp Tyr Phe 
                85                  90                  95      

Ala Lys Gln Leu Glu Ile Phe Pro Leu Leu Asp Glu Glu Ile His Met 
            100                 105                 110         

Arg Ile Thr Glu Met Gly Lys Gln Asn Ile Leu Val Glu Pro Ala Asp 
        115                 120                 125             

Glu Ala Ser Ala Lys Arg Leu Glu Glu Ile Arg Thr Tyr Val Ser Glu 
    130                 135                 140                 

Lys Ala Gly Val Cys Phe Pro Asn His Asp Arg Tyr Gln Phe His Ile 
145                 150                 155                 160 

Ser Ile Gly Tyr Leu Arg Ile Pro Leu Thr Glu Glu Glu Glu Glu Glu 
                165                 170                 175     

Phe Thr Lys Val Arg Ala Glu Leu Thr Glu Ile Leu Leu Glu Lys Ile 
            180                 185                 190         

Pro Thr Ile Thr Val Asn Arg Ile Asp Tyr Thr Val Phe Glu Asp Met 
        195                 200                 205             

Arg Gln Phe Val Pro Tyr His Glu Lys Phe Lys 
    210                 215                 

<210>   3781
<211>   1008
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3781
atggcaatat tggtaacagg cggagctggt tatattggta gccataccgt agtagaatta   60
ctaaatttag gaaaggaagt tatcattgtc gacaaccttt cgaactctag catcttggtg   120
ctagaccgta ttgaagcaat tacaggaata cgtcccgtgt tttacgaatt agatgtttgt   180
gataaacaag cattgagaaa ggtatttgaa caagaatcga ttgatgctgc aattcatttt   240
gcaggttata aagctgtcgg agaatccgtg caaaagcctg tgatgtacta caaaaataat   300
attatgagta cattggcact tgttgaagtg atgtcagaat ttaatgttaa aaagattgtc   360
ttttcttcaa gtgcgactgt atatggaatt aacaatcagt cacctctaat tgagacgatg   420
caaacaagtg cgacaaatcc ttatgggtat acgaaagtga tgcttgagca aattttaaaa   480
gatgttcatg tggcagattc agaatggagt attgcgttgc ttcgttattt caatccaatt   540
ggtgctcatg agtctggttt gattggggaa gatccctcag gaattcctaa caacttgatg   600
ccttatattg cacaagtagc ggtaggtaag ctatcagagc taagtgtgtt cggaaatgat   660
tatgatacgc ttgatggtac tggtgtgcgt gattatatcc atgtagtaga tttagcaata   720
ggacatataa aagctttaga aaaagtatct gaaaaaacag atgtttatat ctataaccta   780
ggctcgggag aaggcactag tgtattacaa cttgtaaata catttgaaag tgttaataag   840
atccctattc cttataaaat agttccaaga cgttcaggag acgttgcaac ttgttatgca   900
aatgcagaca aagcatataa ggaattaaat tggaggacaa caaaatcgat tgaagacatg   960
tgtagagata catggaattg gcaatcaaaa aatcccaatg gctataat                1008

<210>   3782
<211>   336
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-glucose 4-epimerase (galE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903689 (0.E+01)

<400>   3782
Met Ala Ile Leu Val Thr Gly Gly Ala Gly Tyr Ile Gly Ser His Thr 
1               5                   10                  15      

Val Val Glu Leu Leu Asn Leu Gly Lys Glu Val Ile Ile Val Asp Asn 
            20                  25                  30          

Leu Ser Asn Ser Ser Ile Leu Val Leu Asp Arg Ile Glu Ala Ile Thr 
        35                  40                  45              

Gly Ile Arg Pro Val Phe Tyr Glu Leu Asp Val Cys Asp Lys Gln Ala 
    50                  55                  60                  

Leu Arg Lys Val Phe Glu Gln Glu Ser Ile Asp Ala Ala Ile His Phe 
65                  70                  75                  80  

Ala Gly Tyr Lys Ala Val Gly Glu Ser Val Gln Lys Pro Val Met Tyr 
                85                  90                  95      

Tyr Lys Asn Asn Ile Met Ser Thr Leu Ala Leu Val Glu Val Met Ser 
            100                 105                 110         

Glu Phe Asn Val Lys Lys Ile Val Phe Ser Ser Ser Ala Thr Val Tyr 
        115                 120                 125             

Gly Ile Asn Asn Gln Ser Pro Leu Ile Glu Thr Met Gln Thr Ser Ala 
    130                 135                 140                 

Thr Asn Pro Tyr Gly Tyr Thr Lys Val Met Leu Glu Gln Ile Leu Lys 
145                 150                 155                 160 

Asp Val His Val Ala Asp Ser Glu Trp Ser Ile Ala Leu Leu Arg Tyr 
                165                 170                 175     

Phe Asn Pro Ile Gly Ala His Glu Ser Gly Leu Ile Gly Glu Asp Pro 
            180                 185                 190         

Ser Gly Ile Pro Asn Asn Leu Met Pro Tyr Ile Ala Gln Val Ala Val 
        195                 200                 205             


Gly Lys Leu Ser Glu Leu Ser Val Phe Gly Asn Asp Tyr Asp Thr Leu 
    210                 215                 220                 

Asp Gly Thr Gly Val Arg Asp Tyr Ile His Val Val Asp Leu Ala Ile 
225                 230                 235                 240 

Gly His Ile Lys Ala Leu Glu Lys Val Ser Glu Lys Thr Asp Val Tyr 
                245                 250                 255     

Ile Tyr Asn Leu Gly Ser Gly Glu Gly Thr Ser Val Leu Gln Leu Val 
            260                 265                 270         

Asn Thr Phe Glu Ser Val Asn Lys Ile Pro Ile Pro Tyr Lys Ile Val 
        275                 280                 285             

Pro Arg Arg Ser Gly Asp Val Ala Thr Cys Tyr Ala Asn Ala Asp Lys 
    290                 295                 300                 

Ala Tyr Lys Glu Leu Asn Trp Arg Thr Thr Lys Ser Ile Glu Asp Met 
305                 310                 315                 320 

Cys Arg Asp Thr Trp Asn Trp Gln Ser Lys Asn Pro Asn Gly Tyr Asn 
                325                 330                 335     


<210>   3783
<211>   1473
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3783
atgaaaacaa ttattgataa ttttgttgat agagtaattg aatacggaat gtataatgaa   60
attgacaaaa tatatgtgaa aaatagagta ctagcgttaa taggtgagga gggaattgat   120
cgcatttccg atgaaaatga cctgaaacaa ataaaagatt acttagtgga aatcgcctta   180
aaaaacggta aaattaaaga tttaatcgag gaaaaggaat gtttaggagc agagttaatg   240
aatttcatag ttcctttacc tagtcgatta aatgatattt tttggagttc atatgatata   300
tcacctcaag aagcagttga agagttttat aagttaagta aagatagtga ttatattaaa   360
acttctgcta ttgctaagaa tattgagttt cgagcatcaa ctaaatacgg agagctagag   420
attacgataa atttgtcaaa acccgaaaaa gatccaaaaa caattgctgc tgaaaaatta   480
gtaaaagcaa ctaattatcc caaatgttta ctatgtatgg aaaatgaagg atatcagggg   540
cgaataaatt atccagcacg ttcgaatcat agaattattc ggttgaaact tggtgacgaa   600
gtatggggat tccagtattc tccctactca tactttaatg agcatgcgat atttttgaat   660
agtcaacatg taccaatggc tattacctct aaaacatttg aacaattatt ggagattgtt   720
gatattttgc caggatattt tgctggttca aattctgatc ttcctatctc aggaggctcc   780
attcttagtc ataaccacta ccagggaggg aaacatattt tcccaatgga aaaagcaaaa   840
tttgagagtg aattttgttt taaagacttt gaggatgtta atgctggtat tgtaaaatgg   900
ccaatgtcag taattaggtt acaaagtgaa aataaaaatc gcttgttaga tttagctact   960
aaaattctaa ataagtggag agaatattca gatttagaag tagacatcat tgctatgact   1020
gaagatgtcc cacaccatac ggtgactcct attgctcgta aagtggacgg gagatacgaa   1080
ttagatattg ttctaagaga taatcatact actgaacaat acccagatgg tgttttccat   1140
cctcatcaag atgtacaaca tattaaaaag gaaaatatcg ggttaatcga agtgatggga   1200
cttgcgatat taccacctcg tttgaaacca gagttagaag aagttggaaa atatctttta   1260
ggagaggata atgcaattgc ggattatcat ttagaatggg ccgaccaatt gaaagaaaaa   1320
tatcctcgca ttaataaaga agaggttaat agcgtagttc aacacgaagc aggacaagtg   1380
tttgcgagag ttctggaaga tgcaggagtt tataagaata caccgtctgg gcatgaagcg   1440
tttatgagat ttgttaagtc ggttggaatt aat                                1473

<210>   3784
<211>   491
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   galactose-1-phosphate uridylyltransferase (galT)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903690 (0.E+01)

<400>   3784
Met Lys Thr Ile Ile Asp Asn Phe Val Asp Arg Val Ile Glu Tyr Gly 
1               5                   10                  15      

Met Tyr Asn Glu Ile Asp Lys Ile Tyr Val Lys Asn Arg Val Leu Ala 
            20                  25                  30          

Leu Ile Gly Glu Glu Gly Ile Asp Arg Ile Ser Asp Glu Asn Asp Leu 
        35                  40                  45              

Lys Gln Ile Lys Asp Tyr Leu Val Glu Ile Ala Leu Lys Asn Gly Lys 
    50                  55                  60                  

Ile Lys Asp Leu Ile Glu Glu Lys Glu Cys Leu Gly Ala Glu Leu Met 
65                  70                  75                  80  

Asn Phe Ile Val Pro Leu Pro Ser Arg Leu Asn Asp Ile Phe Trp Ser 
                85                  90                  95      

Ser Tyr Asp Ile Ser Pro Gln Glu Ala Val Glu Glu Phe Tyr Lys Leu 
            100                 105                 110         

Ser Lys Asp Ser Asp Tyr Ile Lys Thr Ser Ala Ile Ala Lys Asn Ile 
        115                 120                 125             

Glu Phe Arg Ala Ser Thr Lys Tyr Gly Glu Leu Glu Ile Thr Ile Asn 
    130                 135                 140                 

Leu Ser Lys Pro Glu Lys Asp Pro Lys Thr Ile Ala Ala Glu Lys Leu 
145                 150                 155                 160 

Val Lys Ala Thr Asn Tyr Pro Lys Cys Leu Leu Cys Met Glu Asn Glu 
                165                 170                 175     

Gly Tyr Gln Gly Arg Ile Asn Tyr Pro Ala Arg Ser Asn His Arg Ile 
            180                 185                 190         

Ile Arg Leu Lys Leu Gly Asp Glu Val Trp Gly Phe Gln Tyr Ser Pro 
        195                 200                 205             

Tyr Ser Tyr Phe Asn Glu His Ala Ile Phe Leu Asn Ser Gln His Val 
    210                 215                 220                 

Pro Met Ala Ile Thr Ser Lys Thr Phe Glu Gln Leu Leu Glu Ile Val 
225                 230                 235                 240 

Asp Ile Leu Pro Gly Tyr Phe Ala Gly Ser Asn Ser Asp Leu Pro Ile 
                245                 250                 255     

Ser Gly Gly Ser Ile Leu Ser His Asn His Tyr Gln Gly Gly Lys His 
            260                 265                 270         

Ile Phe Pro Met Glu Lys Ala Lys Phe Glu Ser Glu Phe Cys Phe Lys 
        275                 280                 285             

Asp Phe Glu Asp Val Asn Ala Gly Ile Val Lys Trp Pro Met Ser Val 
    290                 295                 300                 

Ile Arg Leu Gln Ser Glu Asn Lys Asn Arg Leu Leu Asp Leu Ala Thr 
305                 310                 315                 320 

Lys Ile Leu Asn Lys Trp Arg Glu Tyr Ser Asp Leu Glu Val Asp Ile 
                325                 330                 335     

Ile Ala Met Thr Glu Asp Val Pro His His Thr Val Thr Pro Ile Ala 
            340                 345                 350         

Arg Lys Val Asp Gly Arg Tyr Glu Leu Asp Ile Val Leu Arg Asp Asn 
        355                 360                 365             

His Thr Thr Glu Gln Tyr Pro Asp Gly Val Phe His Pro His Gln Asp 
    370                 375                 380                 

Val Gln His Ile Lys Lys Glu Asn Ile Gly Leu Ile Glu Val Met Gly 
385                 390                 395                 400 

Leu Ala Ile Leu Pro Pro Arg Leu Lys Pro Glu Leu Glu Glu Val Gly 
                405                 410                 415     

Lys Tyr Leu Leu Gly Glu Asp Asn Ala Ile Ala Asp Tyr His Leu Glu 
            420                 425                 430         

Trp Ala Asp Gln Leu Lys Glu Lys Tyr Pro Arg Ile Asn Lys Glu Glu 
        435                 440                 445             

Val Asn Ser Val Val Gln His Glu Ala Gly Gln Val Phe Ala Arg Val 
    450                 455                 460                 

Leu Glu Asp Ala Gly Val Tyr Lys Asn Thr Pro Ser Gly His Glu Ala 
465                 470                 475                 480 

Phe Met Arg Phe Val Lys Ser Val Gly Ile Asn 
                485                 490     

<210>   3785
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3785
atgttaaggt tatatttaga aaatgaaatt atagaattat caaataattt agagaccatt   60
tgggtatctg tgcttgataa atatgagaag ttatttgaat atttatcaaa tgaagaacga   120
gtagaattga ttaaagaaga tttaatcata aatgagtcag ttctaaatat tgataaaaaa   180
ggatatgagt taatttgttt acaacatcct gtttcatatg acttaagaag aattattagt   240
gtaataaaaa tatcaactga cattgaacgt attggggata gaattgttga aattttaaaa   300
aatctacaga ttcttcaaaa taatgaaatt ttgaagaaaa ttatttcaaa aataaaaata   360
cttcatgaag ttatcggact gcatatgaat agggctatat cttgttatag agaggaacaa   420
tctggatgtt tagatatggt tgttatacaa aaacagaatg agatagaaga gcttagtata   480
aatatggaaa agaaaataat gaattacata tttgaagatg atgggaacgt ttctgaagta   540
attagtgctt tagatattat tcatcacctt gataaaattg ctcatactac gcaagcaatt   600
tataaatgga taatgtatag aaaatatggg aacataaat                          639

<210>   3786
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate transport system regulatory protein PhoU, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903691 (e-116)

<400>   3786
Met Leu Arg Leu Tyr Leu Glu Asn Glu Ile Ile Glu Leu Ser Asn Asn 
1               5                   10                  15      

Leu Glu Thr Ile Trp Val Ser Val Leu Asp Lys Tyr Glu Lys Leu Phe 
            20                  25                  30          

Glu Tyr Leu Ser Asn Glu Glu Arg Val Glu Leu Ile Lys Glu Asp Leu 
        35                  40                  45              

Ile Ile Asn Glu Ser Val Leu Asn Ile Asp Lys Lys Gly Tyr Glu Leu 
    50                  55                  60                  

Ile Cys Leu Gln His Pro Val Ser Tyr Asp Leu Arg Arg Ile Ile Ser 
65                  70                  75                  80  

Val Ile Lys Ile Ser Thr Asp Ile Glu Arg Ile Gly Asp Arg Ile Val 
                85                  90                  95      

Glu Ile Leu Lys Asn Leu Gln Ile Leu Gln Asn Asn Glu Ile Leu Lys 
            100                 105                 110         

Lys Ile Ile Ser Lys Ile Lys Ile Leu His Glu Val Ile Gly Leu His 
        115                 120                 125             

Met Asn Arg Ala Ile Ser Cys Tyr Arg Glu Glu Gln Ser Gly Cys Leu 
    130                 135                 140                 

Asp Met Val Val Ile Gln Lys Gln Asn Glu Ile Glu Glu Leu Ser Ile 
145                 150                 155                 160 

Asn Met Glu Lys Lys Ile Met Asn Tyr Ile Phe Glu Asp Asp Gly Asn 
                165                 170                 175     

Val Ser Glu Val Ile Ser Ala Leu Asp Ile Ile His His Leu Asp Lys 
            180                 185                 190         

Ile Ala His Thr Thr Gln Ala Ile Tyr Lys Trp Ile Met Tyr Arg Lys 
        195                 200                 205             

Tyr Gly Asn Ile Asn 
    210             

<210>   3787
<211>   480
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3787
gtgtactatt ctagtttcaa tatactatat tatcgcttac caatatttgc taaactttca   60
gaaaaaaagt tggagtatat gatgctaggt gactgcgtca tgttagtaaa cgaaatggaa   120
ataactgatc atagagtaga taacttattt gaaaaaggga aaaatgagat aaaagattca   180
attggtacaa atagtgtttt aaataaaaaa attattttac aaaaaatcag aaaattatct   240
aatcaaccga gtgggtactg gataggttcg ttggatgaga gatttttaga ccatgctatt   300
attaatcaaa tagatgttac tagtgaacaa attgttttaa tgagcgatgg cttttatgaa   360
ttctatcaaa ataatcaaaa taaaactttt gaagagttaa ttaagatgag atttaattct   420
tctgctattg atccaatcta tggaaagaag gatgatgcaa gtattctagt cattgatgtt   480

<210>   3788
<211>   160
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903692 (7.E-87)

<400>   3788
Met Tyr Tyr Ser Ser Phe Asn Ile Leu Tyr Tyr Arg Leu Pro Ile Phe 
1               5                   10                  15      

Ala Lys Leu Ser Glu Lys Lys Leu Glu Tyr Met Met Leu Gly Asp Cys 
            20                  25                  30          

Val Met Leu Val Asn Glu Met Glu Ile Thr Asp His Arg Val Asp Asn 
        35                  40                  45              

Leu Phe Glu Lys Gly Lys Asn Glu Ile Lys Asp Ser Ile Gly Thr Asn 
    50                  55                  60                  

Ser Val Leu Asn Lys Lys Ile Ile Leu Gln Lys Ile Arg Lys Leu Ser 
65                  70                  75                  80  

Asn Gln Pro Ser Gly Tyr Trp Ile Gly Ser Leu Asp Glu Arg Phe Leu 
                85                  90                  95      

Asp His Ala Ile Ile Asn Gln Ile Asp Val Thr Ser Glu Gln Ile Val 
            100                 105                 110         

Leu Met Ser Asp Gly Phe Tyr Glu Phe Tyr Gln Asn Asn Gln Asn Lys 
        115                 120                 125             

Thr Phe Glu Glu Leu Ile Lys Met Arg Phe Asn Ser Ser Ala Ile Asp 
    130                 135                 140                 

Pro Ile Tyr Gly Lys Lys Asp Asp Ala Ser Ile Leu Val Ile Asp Val 
145                 150                 155                 160 


<210>   3789
<211>   294
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3789
atggtaaaga taaataaaat ttgttcgata caaggaagtt ccgtagaaaa tgaggatatt   60
gtaggttcac aaaatcagta tttttggatt attggtggag ctacagattt atataattct   120
aaagaggaga taggttattc agtctcagaa gttgtacata ttttatcaga aagtttgtcg   180
gttaattgta aagaatcaaa aactcttaaa caaatatttg aaactgcttt actcgaggtt   240
aaagatgaaa tcggtttaaa ctcatataaa ttaacagagt atagtaaaat gaaa         294

<210>   3790
<211>   98
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903693 (5.E-51)

<400>   3790
Met Val Lys Ile Asn Lys Ile Cys Ser Ile Gln Gly Ser Ser Val Glu 
1               5                   10                  15      

Asn Glu Asp Ile Val Gly Ser Gln Asn Gln Tyr Phe Trp Ile Ile Gly 
            20                  25                  30          

Gly Ala Thr Asp Leu Tyr Asn Ser Lys Glu Glu Ile Gly Tyr Ser Val 
        35                  40                  45              

Ser Glu Val Val His Ile Leu Ser Glu Ser Leu Ser Val Asn Cys Lys 
    50                  55                  60                  

Glu Ser Lys Thr Leu Lys Gln Ile Phe Glu Thr Ala Leu Leu Glu Val 
65                  70                  75                  80  

Lys Asp Glu Ile Gly Leu Asn Ser Tyr Lys Leu Thr Glu Tyr Ser Lys 
                85                  90                  95      

Met Lys 
        

<210>   3791
<211>   2124
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3791
atgaaatatt ttgttcctaa tgaggtattc agtattcgta aattaaaggt ggggacttgc   60
tcggtactat tggcaatttc aattttggga agccaaggta ttttatcgga tgaagttgtt   120
actagttctt caccgatggc tacaaaagag tcttctaatg caattactaa tgatttagat   180
aattcaccaa ctgttaatca gaatcgttct gctgaaatga ttgcctctaa ttcaaccact   240
aatggtttag ataattcgtt aagtgttaat agtatcagct ctaatggtac tattcgttcc   300
aattcacaat tagacaacag aacagttgaa tctacagtaa catctactaa tgaaaataag   360
agttataagg aagatgttat aagtgacaga attatcaaaa aagaatttga agatactgct   420
ttaagtgtaa aagattatgg tgcggtaggt gatgggattc atgatgatcg acaagcaatt   480
caagatgcaa tagatgctgc agctcaaggg ctaggtggag gaaatgtata ttttcctgaa   540
ggaacttatt tagtaaaaga aattgttttt ttaaaaagtc atacacactt agaattgaat   600
gagaaagcta caattctaaa tggtataaat attaagaatc acccttccat tgtttttatg   660
acaggtttat ttacggatga tggtgcgcaa gtagaatggg gcccaacaga agatattagt   720
tattctggtg gtacgattga tatgaacggt gctttgaatg aagaaggaac taaagcaaaa   780
aatctaccac ttataaattc ttcaggtgca tttgctattg ggaattcaaa taacgtaact   840
ataaaaaatg taacattcaa ggatagttat caagggcatg ctattcaaat tgcaggttcg   900
aaaaatgtat tagttgataa ttctcgtttt cttgggcaag ccttacccaa aacgatgaag   960
gatgggcaaa tcataagtaa ggagagcatt cagattgaac cattaactag aaaaggtttt   1020
ccttatgcct tgaatgatga tgggaaaaaa tctgaaaatg tgactattca aaattcctat   1080
tttggcaaaa gtgataaatc tggggaatta gtaacagcaa ttggcacaca ctatcaaaca   1140
ttgtcgacac agaacccctc taatattaaa attcaaaata atcattttga taacatgatg   1200
tatgcaggtg tacgttttac aggattcact gatgtattaa tcaaaggaaa tcgctttgat   1260
aagaaagtta aaggagagag tgtacattat cgagaaagcg gagcagcttt agtaaatgct   1320
tatagctata aaaacactaa agacctatta gatttaaata aacaggtggt tatcgccgaa   1380
aatatattta atattgccga tcctaaaaca aaagcgatac gagttgcaaa agatagtgca   1440
gaatatttag gaaaagtatc agatattact gtaacaaaaa atgtaattaa taataattct   1500
aaggaaacag aacaaccaaa tattgaatta ttacgagtta gtgataattt agtagtctca   1560
gagaatagta tattcggggg taaagaagga attgttattg aggattcaaa gggtaaaata   1620
accgttttaa ataaccaatt ttataattta tccggtaagt atatatcatt catcaaatct   1680
aatgcaaatg ggaaagaacc tgttatacgt gatagcgatg gtaatttcaa tattgtaacg   1740
gagaatgggc tttacaaaat tgtaacaaat aatttaagtg ataaaaacga aaaagaaaaa   1800
aacaaagagg aaaaacaatc taattcaaat aatgtaattg atagtaacca gaagaacgga   1860
gagtttaact caagtaaaga taatagacaa atgaatgaca agatcgacaa taaacaagat   1920
aataagacag aagaagtaaa ctataaaata gttggagatg gcagagaaac tgaaaatcat   1980
attaataaat ctaaagaaat agtagatgta aaacaaaaat taccaaagac tggttcgaat   2040
aagattatgg aactattctt aacagtgaca ggaattggtt tacttttgac actaaaaggg   2100
ttgaagtatt atggtaaaga taaa                                          2124

<210>   3792
<211>   708
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell wall surface anchor family protein
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15903694 (0.E+01)

<400>   3792
Met Lys Tyr Phe Val Pro Asn Glu Val Phe Ser Ile Arg Lys Leu Lys 
1               5                   10                  15      

Val Gly Thr Cys Ser Val Leu Leu Ala Ile Ser Ile Leu Gly Ser Gln 
            20                  25                  30          

Gly Ile Leu Ser Asp Glu Val Val Thr Ser Ser Ser Pro Met Ala Thr 
        35                  40                  45              

Lys Glu Ser Ser Asn Ala Ile Thr Asn Asp Leu Asp Asn Ser Pro Thr 
    50                  55                  60                  

Val Asn Gln Asn Arg Ser Ala Glu Met Ile Ala Ser Asn Ser Thr Thr 
65                  70                  75                  80  

Asn Gly Leu Asp Asn Ser Leu Ser Val Asn Ser Ile Ser Ser Asn Gly 
                85                  90                  95      

Thr Ile Arg Ser Asn Ser Gln Leu Asp Asn Arg Thr Val Glu Ser Thr 
            100                 105                 110         

Val Thr Ser Thr Asn Glu Asn Lys Ser Tyr Lys Glu Asp Val Ile Ser 
        115                 120                 125             

Asp Arg Ile Ile Lys Lys Glu Phe Glu Asp Thr Ala Leu Ser Val Lys 
    130                 135                 140                 

Asp Tyr Gly Ala Val Gly Asp Gly Ile His Asp Asp Arg Gln Ala Ile 
145                 150                 155                 160 

Gln Asp Ala Ile Asp Ala Ala Ala Gln Gly Leu Gly Gly Gly Asn Val 
                165                 170                 175     

Tyr Phe Pro Glu Gly Thr Tyr Leu Val Lys Glu Ile Val Phe Leu Lys 
            180                 185                 190         


Ser His Thr His Leu Glu Leu Asn Glu Lys Ala Thr Ile Leu Asn Gly 
        195                 200                 205             

Ile Asn Ile Lys Asn His Pro Ser Ile Val Phe Met Thr Gly Leu Phe 
    210                 215                 220                 

Thr Asp Asp Gly Ala Gln Val Glu Trp Gly Pro Thr Glu Asp Ile Ser 
225                 230                 235                 240 

Tyr Ser Gly Gly Thr Ile Asp Met Asn Gly Ala Leu Asn Glu Glu Gly 
                245                 250                 255     

Thr Lys Ala Lys Asn Leu Pro Leu Ile Asn Ser Ser Gly Ala Phe Ala 
            260                 265                 270         

Ile Gly Asn Ser Asn Asn Val Thr Ile Lys Asn Val Thr Phe Lys Asp 
        275                 280                 285             

Ser Tyr Gln Gly His Ala Ile Gln Ile Ala Gly Ser Lys Asn Val Leu 
    290                 295                 300                 

Val Asp Asn Ser Arg Phe Leu Gly Gln Ala Leu Pro Lys Thr Met Lys 
305                 310                 315                 320 

Asp Gly Gln Ile Ile Ser Lys Glu Ser Ile Gln Ile Glu Pro Leu Thr 
                325                 330                 335     

Arg Lys Gly Phe Pro Tyr Ala Leu Asn Asp Asp Gly Lys Lys Ser Glu 
            340                 345                 350         

Asn Val Thr Ile Gln Asn Ser Tyr Phe Gly Lys Ser Asp Lys Ser Gly 
        355                 360                 365             

Glu Leu Val Thr Ala Ile Gly Thr His Tyr Gln Thr Leu Ser Thr Gln 
    370                 375                 380                 

Asn Pro Ser Asn Ile Lys Ile Gln Asn Asn His Phe Asp Asn Met Met 
385                 390                 395                 400 

Tyr Ala Gly Val Arg Phe Thr Gly Phe Thr Asp Val Leu Ile Lys Gly 
                405                 410                 415     

Asn Arg Phe Asp Lys Lys Val Lys Gly Glu Ser Val His Tyr Arg Glu 
            420                 425                 430         

Ser Gly Ala Ala Leu Val Asn Ala Tyr Ser Tyr Lys Asn Thr Lys Asp 
        435                 440                 445             

Leu Leu Asp Leu Asn Lys Gln Val Val Ile Ala Glu Asn Ile Phe Asn 
    450                 455                 460                 

Ile Ala Asp Pro Lys Thr Lys Ala Ile Arg Val Ala Lys Asp Ser Ala 
465                 470                 475                 480 

Glu Tyr Leu Gly Lys Val Ser Asp Ile Thr Val Thr Lys Asn Val Ile 
                485                 490                 495     

Asn Asn Asn Ser Lys Glu Thr Glu Gln Pro Asn Ile Glu Leu Leu Arg 
            500                 505                 510         

Val Ser Asp Asn Leu Val Val Ser Glu Asn Ser Ile Phe Gly Gly Lys 
        515                 520                 525             

Glu Gly Ile Val Ile Glu Asp Ser Lys Gly Lys Ile Thr Val Leu Asn 
    530                 535                 540                 

Asn Gln Phe Tyr Asn Leu Ser Gly Lys Tyr Ile Ser Phe Ile Lys Ser 
545                 550                 555                 560 

Asn Ala Asn Gly Lys Glu Pro Val Ile Arg Asp Ser Asp Gly Asn Phe 
                565                 570                 575     

Asn Ile Val Thr Glu Asn Gly Leu Tyr Lys Ile Val Thr Asn Asn Leu 
            580                 585                 590         

Ser Asp Lys Asn Glu Lys Glu Lys Asn Lys Glu Glu Lys Gln Ser Asn 
        595                 600                 605             

Ser Asn Asn Val Ile Asp Ser Asn Gln Lys Asn Gly Glu Phe Asn Ser 
    610                 615                 620                 

Ser Lys Asp Asn Arg Gln Met Asn Asp Lys Ile Asp Asn Lys Gln Asp 
625                 630                 635                 640 

Asn Lys Thr Glu Glu Val Asn Tyr Lys Ile Val Gly Asp Gly Arg Glu 
                645                 650                 655     

Thr Glu Asn His Ile Asn Lys Ser Lys Glu Ile Val Asp Val Lys Gln 
            660                 665                 670         

Lys Leu Pro Lys Thr Gly Ser Asn Lys Ile Met Glu Leu Phe Leu Thr 
        675                 680                 685             

Val Thr Gly Ile Gly Leu Leu Leu Thr Leu Lys Gly Leu Lys Tyr Tyr 
    690                 695                 700                 

Gly Lys Asp Lys 
705             

<210>   3793
<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3793
atgagcgata ttcaggtaaa tatccctggc gaatgcttgt atgacaaggt atttgttctt   60
tcatttataa tttacaacat atcaacaaat ttaaatatag taaatgggat attttatatt   120
caagctaaga aagatagcat cacttttgaa tggaaggcta aagagcaaac taggaagttg   180
gccatagata gctcaaaacc ctgctttgag gttgtagata tagtaaaa                228

<210>   3794
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3794
Met Ser Asp Ile Gln Val Asn Ile Pro Gly Glu Cys Leu Tyr Asp Lys 
1               5                   10                  15      

Val Phe Val Leu Ser Phe Ile Ile Tyr Asn Ile Ser Thr Asn Leu Asn 
            20                  25                  30          

Ile Val Asn Gly Ile Phe Tyr Ile Gln Ala Lys Lys Asp Ser Ile Thr 
        35                  40                  45              

Phe Glu Trp Lys Ala Lys Glu Gln Thr Arg Lys Leu Ala Ile Asp Ser 
    50                  55                  60                  

Ser Lys Pro Cys Phe Glu Val Val Asp Ile Val Lys 
65                  70                  75      

<210>   3795
<211>   123
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3795
atgagtgaga ttgtggaaac tcgcgtcttt ttttgttttc agaatattgt tcaaaatttt   60
gtgcctgtct ttcatgttct agtcattctt ttgcatgata gaatttatag catgttgata   120
tta                                                                 123

<210>   3796
<211>   41
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   3796
Met Ser Glu Ile Val Glu Thr Arg Val Phe Phe Cys Phe Gln Asn Ile 
1               5                   10                  15      

Val Gln Asn Phe Val Pro Val Phe His Val Leu Val Ile Leu Leu His 
            20                  25                  30          

Asp Arg Ile Tyr Ser Met Leu Ile Leu 
        35                  40      

<210>   3797
<211>   174
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3797
atgatgtcta gtaaggattc taaatgctac actaaattgc tcacatctta tttcaaacca   60
cgggactccc acaagaaagg aaaatcctat aaaaattctc tctctgagga gaaaggggcc   120
tcaactacag gtgtaaacta ttatcaattg aaaacaacag tttttacact caat         174

<210>   3798
<211>   58
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903695 (4.E-29)

<400>   3798
Met Met Ser Ser Lys Asp Ser Lys Cys Tyr Thr Lys Leu Leu Thr Ser 
1               5                   10                  15      

Tyr Phe Lys Pro Arg Asp Ser His Lys Lys Gly Lys Ser Tyr Lys Asn 
            20                  25                  30          

Ser Leu Ser Glu Glu Lys Gly Ala Ser Thr Thr Gly Val Asn Tyr Tyr 
        35                  40                  45              

Gln Leu Lys Thr Thr Val Phe Thr Leu Asn 
    50                  55              

<210>   3799
<211>   1251
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3799
atgagtacag ataaaaggag caaatcaatg ccaaattaca atattccatt ttcaccgcct   60
gatatcacag aagcagaaat tactgaagta gtggataccc tgcgttctgg ttggatcaca   120
acaggtccta aaacaaaaga actggagcgc cgcttgtctc tttacacaca gacacctaag   180
actgtttgtc tcaactctgc gacagccgct ctggagttga ttttacgcgt tttggaagtg   240
ggacctggtg atgaagtcat cgttccagcc atgacctata cggcttcatg tagtgtcatt   300
acgcacgtgg gagcaacccc tgtcatggtg gatatccaag cagatacgtt tgagatggac   360
tatgacctgc ttgagcaagc tatcactgag aaaactaagg tgattattcc agtagagctc   420
gcagggattg tttgcgatta tgaccgtttg ttccaagtcg tggagaaaaa acgtgacttc   480
tttaccgctt caagcaagtg gcaaaaggcc tttaaccgta ttgtcattgt ctctgatagt   540
gcccacgctt tgggatctat ttataaagga caaccttctg gttctatcgc tgactttact   600
tccttctcat tccatgcagt taagaacttt acaacggcag aaggtggaag tgcgacttgg   660
aaagccaatc cagtgattga tgacgaagag atgtacaagg aattccaaat cctttccctt   720
cacgggcaaa ctaaggatgc tcttgccaag atgcaactgg ggtcatggga atacgatatc   780
gttacaccag cctataagtg caacatgacc gatatcatgg cttcacttgg tttggtacaa   840
ttggaccgct atccaagttt gttgcaacgc cgtaaggaca ttgtggaccg ctatgatagt   900
ggttttgcag gttctcgcat ccatcctttg gcacacaaga ctgaaactgt cgaatcttca   960
cgccacctct acatcacccg tgtagaagga gcaagcctag aagaacgcaa cctcatcatc   1020
caagaattgg ctaaagcagg aattgcaagt aatgttcact acaaaccgct tcctctcttg   1080
acagcctata agaatcttgg atttgatatg acgaactatc ctaaggccta tgccttcttt   1140
gagaatgaaa ttaccctccc tcttcatact aaattaagcg atgaagaagt agactatatc   1200
attgagactt tcaaaacagt ttctgaaaaa gtgctaactt tatcaaaaaa a            1251

<210>   3800
<211>   417
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903696 (0.E+01)

<400>   3800
Met Ser Thr Asp Lys Arg Ser Lys Ser Met Pro Asn Tyr Asn Ile Pro 
1               5                   10                  15      

Phe Ser Pro Pro Asp Ile Thr Glu Ala Glu Ile Thr Glu Val Val Asp 
            20                  25                  30          

Thr Leu Arg Ser Gly Trp Ile Thr Thr Gly Pro Lys Thr Lys Glu Leu 
        35                  40                  45              

Glu Arg Arg Leu Ser Leu Tyr Thr Gln Thr Pro Lys Thr Val Cys Leu 
    50                  55                  60                  

Asn Ser Ala Thr Ala Ala Leu Glu Leu Ile Leu Arg Val Leu Glu Val 
65                  70                  75                  80  

Gly Pro Gly Asp Glu Val Ile Val Pro Ala Met Thr Tyr Thr Ala Ser 
                85                  90                  95      

Cys Ser Val Ile Thr His Val Gly Ala Thr Pro Val Met Val Asp Ile 
            100                 105                 110         

Gln Ala Asp Thr Phe Glu Met Asp Tyr Asp Leu Leu Glu Gln Ala Ile 
        115                 120                 125             

Thr Glu Lys Thr Lys Val Ile Ile Pro Val Glu Leu Ala Gly Ile Val 
    130                 135                 140                 

Cys Asp Tyr Asp Arg Leu Phe Gln Val Val Glu Lys Lys Arg Asp Phe 
145                 150                 155                 160 

Phe Thr Ala Ser Ser Lys Trp Gln Lys Ala Phe Asn Arg Ile Val Ile 
                165                 170                 175     

Val Ser Asp Ser Ala His Ala Leu Gly Ser Ile Tyr Lys Gly Gln Pro 
            180                 185                 190         

Ser Gly Ser Ile Ala Asp Phe Thr Ser Phe Ser Phe His Ala Val Lys 
        195                 200                 205             

Asn Phe Thr Thr Ala Glu Gly Gly Ser Ala Thr Trp Lys Ala Asn Pro 
    210                 215                 220                 

Val Ile Asp Asp Glu Glu Met Tyr Lys Glu Phe Gln Ile Leu Ser Leu 
225                 230                 235                 240 

His Gly Gln Thr Lys Asp Ala Leu Ala Lys Met Gln Leu Gly Ser Trp 
                245                 250                 255     

Glu Tyr Asp Ile Val Thr Pro Ala Tyr Lys Cys Asn Met Thr Asp Ile 
            260                 265                 270         

Met Ala Ser Leu Gly Leu Val Gln Leu Asp Arg Tyr Pro Ser Leu Leu 
        275                 280                 285             

Gln Arg Arg Lys Asp Ile Val Asp Arg Tyr Asp Ser Gly Phe Ala Gly 
    290                 295                 300                 

Ser Arg Ile His Pro Leu Ala His Lys Thr Glu Thr Val Glu Ser Ser 
305                 310                 315                 320 

Arg His Leu Tyr Ile Thr Arg Val Glu Gly Ala Ser Leu Glu Glu Arg 
                325                 330                 335     

Asn Leu Ile Ile Gln Glu Leu Ala Lys Ala Gly Ile Ala Ser Asn Val 
            340                 345                 350         

His Tyr Lys Pro Leu Pro Leu Leu Thr Ala Tyr Lys Asn Leu Gly Phe 
        355                 360                 365             

Asp Met Thr Asn Tyr Pro Lys Ala Tyr Ala Phe Phe Glu Asn Glu Ile 
    370                 375                 380                 

Thr Leu Pro Leu His Thr Lys Leu Ser Asp Glu Glu Val Asp Tyr Ile 
385                 390                 395                 400 

Ile Glu Thr Phe Lys Thr Val Ser Glu Lys Val Leu Thr Leu Ser Lys 
                405                 410                 415     

Lys 
    

<210>   3801
<211>   729
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3801
atgttgacaa atagtataat aaaaacaaag gagaacagca tgctgaaatg ggaagacttg   60
cctgtggaaa tgaaatcaag cgaggttgag tcttactacc agcttgtctc taaaaggaag   120
ggttcgctga ttttcaagcg ttgcttggac tgggttttgg ccttggtctt actggttctg   180
acctctccca tctttctcat cttgagcatt tggatcaagt tggatagcaa agggccagtg   240
atttacaagc aagagcgtgt gacccagtac aaccgtcggt tcaagatttg gaagtttcgt   300
accatggtga cggatgcgga taaaaaagga agtctggtga cttctgctaa cgatagccgc   360
attaccaagg ttggaaattt catccgacgt gtccgtttgg acgaactgcc tcagttggtc   420
aatgtcctta aaggtgagat gtcctttgtc ggtacacgac ctgaagtgcc acgttataca   480
gagcagtata gccctgaaat gatggcaacc ttgctcttgc aagcagggat tacctctcca   540
gccagcatca actacaagga tgaggacaca attatcagtc aaatgacgga gaaaggtctg   600
tcagttgatc aggcctatgt ggagcatgtt cttcctgaaa agatgcgcta taacctcgcc   660
tatctccgag agtttagttt ctttggggac atcaaaatca tgtttcaaac cgtgtttgag   720
gtactaaaa                                                           729

<210>   3802
<211>   243
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903697 (e-129)

<400>   3802
Met Leu Thr Asn Ser Ile Ile Lys Thr Lys Glu Asn Ser Met Leu Lys 
1               5                   10                  15      

Trp Glu Asp Leu Pro Val Glu Met Lys Ser Ser Glu Val Glu Ser Tyr 
            20                  25                  30          

Tyr Gln Leu Val Ser Lys Arg Lys Gly Ser Leu Ile Phe Lys Arg Cys 
        35                  40                  45              

Leu Asp Trp Val Leu Ala Leu Val Leu Leu Val Leu Thr Ser Pro Ile 
    50                  55                  60                  

Phe Leu Ile Leu Ser Ile Trp Ile Lys Leu Asp Ser Lys Gly Pro Val 
65                  70                  75                  80  

Ile Tyr Lys Gln Glu Arg Val Thr Gln Tyr Asn Arg Arg Phe Lys Ile 
                85                  90                  95      

Trp Lys Phe Arg Thr Met Val Thr Asp Ala Asp Lys Lys Gly Ser Leu 
            100                 105                 110         

Val Thr Ser Ala Asn Asp Ser Arg Ile Thr Lys Val Gly Asn Phe Ile 
        115                 120                 125             

Arg Arg Val Arg Leu Asp Glu Leu Pro Gln Leu Val Asn Val Leu Lys 
    130                 135                 140                 

Gly Glu Met Ser Phe Val Gly Thr Arg Pro Glu Val Pro Arg Tyr Thr 
145                 150                 155                 160 

Glu Gln Tyr Ser Pro Glu Met Met Ala Thr Leu Leu Leu Gln Ala Gly 
                165                 170                 175     

Ile Thr Ser Pro Ala Ser Ile Asn Tyr Lys Asp Glu Asp Thr Ile Ile 
            180                 185                 190         

Ser Gln Met Thr Glu Lys Gly Leu Ser Val Asp Gln Ala Tyr Val Glu 
        195                 200                 205             

His Val Leu Pro Glu Lys Met Arg Tyr Asn Leu Ala Tyr Leu Arg Glu 
    210                 215                 220                 

Phe Ser Phe Phe Gly Asp Ile Lys Ile Met Phe Gln Thr Val Phe Glu 
225                 230                 235                 240 

Val Leu Lys 
            

<210>   3803
<211>   1749
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3803
atgcagaata aacaagaaca atggactgta ttgaagcgct tgatgtctta tctcaagcct   60
tatggactcc tgaccttttt ggcactcagt tttctcctag cgacgacggt cattaaaagt   120
gtcatacccc tcgtggcttc ccactttatc gaccagtatc tcagcaatct taaccaacta   180
gccgttaccg ttttgctggt ctactatggt ctctacatcc tacaaactgt agttcagtat   240
gtcggcaatc ttctctttgc gcgcgtgtct tacagtattg ttagggatat tcgtcgggat   300
gcctttgcca atatggagaa actgggcatg tcttactttg acaagacgcc agcaggttct   360
atcgtttctc gtttgaccaa cgataccgag acgattagtg atatgttttc tgggatttta   420
tccagcttta tctcagcagt ttttatcttt ctgacaaccc tttataccat gttggtgctg   480
gattttcgtt tgacggcttt agtcttgctc tttcttcctt tgattttcct tttggtcaat   540
ctctatcgaa aaaagtcagt gaaaatcatc gagaaaacca gaagtctctt gtcagatatc   600
aatagtaagc tggcagagaa tatcgaggga atcaggatta ttcaggcctt taatcaagag   660
aagcgcctgc aggcagaatt tgatgaaatc aaccaagaac acttggtcta cgccaaccgt   720
tctgtagcct tggatgccct ctttttgaga cctgccatga gtttgctgaa acttctaggc   780
tatgcagtct tgatggccta ctttggctac cgtggttttt ctatcgggat aacggtcggg   840
accatgtatg cctttatcca gtacatcaac cgcctttttg accccttgat tgaggtgacg   900
caaaactttt caactctgca aacggctatg gtttctgcag gtcgtgtctt tgccctgata   960
gacgagagga cctatgaacc tcttcaagaa aatgggcaag ccaaagtcca agaaggcaat   1020
atccgttttg aacatgtgtg tttctcatat gacggtaaac atccgattct ggatgacatt   1080
tctttctctg ttaataaggg tgaaaccatt gcctttgtag gtcatacagg ttcagggaaa   1140
tcgtctatta tcaatgtcct catgcgcttt tatgaattcc agtcagggag agttctcttg   1200
gatgatgtgg atatcaggga tttcagtcaa gaagagctga gaaaaaacat cggtttggtc   1260
ttgcaggaac ccttcctcta tcatggaact attaagtcca atatcgccat gtaccaagaa   1320
accagtgatg agcaggttca ggctgcggca gcctttgtgg atgcagattc ctttattcaa   1380
gaacttcctc aggggtacga ctcccctgtt tccgagcgtg gttcgagctt ctctactggg   1440
caacgccagc ttcttgcctt tgctagaaca gtcgccagcc agcctaaaat cctgattttg   1500
gatgaagcga cagccaatat tgactctgaa acagaaagct tggttcaagc ttctctggcg   1560
aagatgagac agggccgaac aactattgct atcgctcacc gcctttctac tattcaagat   1620
gccaactgca tctatgtctt ggataaggga cgcattatcg agagtggaac ccatgaggaa   1680
ctcttggctc tgggaggaac ctatcacaag atgtatagtt tgcaggcagg ggccatggcc   1740
gatactctt                                                           1749

<210>   3804
<211>   583
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903698 (0.E+01)

<400>   3804
Met Gln Asn Lys Gln Glu Gln Trp Thr Val Leu Lys Arg Leu Met Ser 
1               5                   10                  15      

Tyr Leu Lys Pro Tyr Gly Leu Leu Thr Phe Leu Ala Leu Ser Phe Leu 
            20                  25                  30          

Leu Ala Thr Thr Val Ile Lys Ser Val Ile Pro Leu Val Ala Ser His 
        35                  40                  45              

Phe Ile Asp Gln Tyr Leu Ser Asn Leu Asn Gln Leu Ala Val Thr Val 
    50                  55                  60                  

Leu Leu Val Tyr Tyr Gly Leu Tyr Ile Leu Gln Thr Val Val Gln Tyr 
65                  70                  75                  80  

Val Gly Asn Leu Leu Phe Ala Arg Val Ser Tyr Ser Ile Val Arg Asp 
                85                  90                  95      

Ile Arg Arg Asp Ala Phe Ala Asn Met Glu Lys Leu Gly Met Ser Tyr 
            100                 105                 110         

Phe Asp Lys Thr Pro Ala Gly Ser Ile Val Ser Arg Leu Thr Asn Asp 
        115                 120                 125             

Thr Glu Thr Ile Ser Asp Met Phe Ser Gly Ile Leu Ser Ser Phe Ile 
    130                 135                 140                 

Ser Ala Val Phe Ile Phe Leu Thr Thr Leu Tyr Thr Met Leu Val Leu 
145                 150                 155                 160 

Asp Phe Arg Leu Thr Ala Leu Val Leu Leu Phe Leu Pro Leu Ile Phe 
                165                 170                 175     

Leu Leu Val Asn Leu Tyr Arg Lys Lys Ser Val Lys Ile Ile Glu Lys 
            180                 185                 190         

Thr Arg Ser Leu Leu Ser Asp Ile Asn Ser Lys Leu Ala Glu Asn Ile 
        195                 200                 205             

Glu Gly Ile Arg Ile Ile Gln Ala Phe Asn Gln Glu Lys Arg Leu Gln 
    210                 215                 220                 

Ala Glu Phe Asp Glu Ile Asn Gln Glu His Leu Val Tyr Ala Asn Arg 
225                 230                 235                 240 

Ser Val Ala Leu Asp Ala Leu Phe Leu Arg Pro Ala Met Ser Leu Leu 
                245                 250                 255     

Lys Leu Leu Gly Tyr Ala Val Leu Met Ala Tyr Phe Gly Tyr Arg Gly 
            260                 265                 270         

Phe Ser Ile Gly Ile Thr Val Gly Thr Met Tyr Ala Phe Ile Gln Tyr 
        275                 280                 285             

Ile Asn Arg Leu Phe Asp Pro Leu Ile Glu Val Thr Gln Asn Phe Ser 
    290                 295                 300                 

Thr Leu Gln Thr Ala Met Val Ser Ala Gly Arg Val Phe Ala Leu Ile 
305                 310                 315                 320 

Asp Glu Arg Thr Tyr Glu Pro Leu Gln Glu Asn Gly Gln Ala Lys Val 
                325                 330                 335     

Gln Glu Gly Asn Ile Arg Phe Glu His Val Cys Phe Ser Tyr Asp Gly 
            340                 345                 350         

Lys His Pro Ile Leu Asp Asp Ile Ser Phe Ser Val Asn Lys Gly Glu 
        355                 360                 365             

Thr Ile Ala Phe Val Gly His Thr Gly Ser Gly Lys Ser Ser Ile Ile 
    370                 375                 380                 

Asn Val Leu Met Arg Phe Tyr Glu Phe Gln Ser Gly Arg Val Leu Leu 
385                 390                 395                 400 

Asp Asp Val Asp Ile Arg Asp Phe Ser Gln Glu Glu Leu Arg Lys Asn 
                405                 410                 415     

Ile Gly Leu Val Leu Gln Glu Pro Phe Leu Tyr His Gly Thr Ile Lys 
            420                 425                 430         

Ser Asn Ile Ala Met Tyr Gln Glu Thr Ser Asp Glu Gln Val Gln Ala 
        435                 440                 445             

Ala Ala Ala Phe Val Asp Ala Asp Ser Phe Ile Gln Glu Leu Pro Gln 
    450                 455                 460                 

Gly Tyr Asp Ser Pro Val Ser Glu Arg Gly Ser Ser Phe Ser Thr Gly 
465                 470                 475                 480 

Gln Arg Gln Leu Leu Ala Phe Ala Arg Thr Val Ala Ser Gln Pro Lys 
                485                 490                 495     

Ile Leu Ile Leu Asp Glu Ala Thr Ala Asn Ile Asp Ser Glu Thr Glu 
            500                 505                 510         

Ser Leu Val Gln Ala Ser Leu Ala Lys Met Arg Gln Gly Arg Thr Thr 
        515                 520                 525             

Ile Ala Ile Ala His Arg Leu Ser Thr Ile Gln Asp Ala Asn Cys Ile 
    530                 535                 540                 

Tyr Val Leu Asp Lys Gly Arg Ile Ile Glu Ser Gly Thr His Glu Glu 
545                 550                 555                 560 

Leu Leu Ala Leu Gly Gly Thr Tyr His Lys Met Tyr Ser Leu Gln Ala 
                565                 570                 575     

Gly Ala Met Ala Asp Thr Leu 
            580             

<210>   3805
<211>   1677
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3805
gtggccctga tcttggtttc cgtcctcaat ctcattcctc ctatggttat ggggcgggtc   60
attgatgcca tcacatcggg gcaattaacc cagcaggacc tccttcttag cctattttac   120
ttgctacttg cagcctttgg tatgtactat ttgcgctatg tgtggcgtat gtatatcctt   180
gggacctctt attgcttggg acagatcatg cggtctcgct tgtttaagca tttcacaaaa   240
atgtcgtcag ccttttatca aacctatcgg acgggtgatc tgatggcaca cgcaaccaat   300
gatatcaatg ccttgactcg tttagcaggt ggcggtgtca tgtctgcggt ggatgcctct   360
atcacggctc tggtgacttt gttgaccatg ctctttagca tctcatggca gatgactctt   420
gttgccattc tccccctacc tttcatggcc tatacgacta gtcgcctagg gagaaagact   480
cataaggcct ttggcgaatc ccaagctgct ttttctgaac tcaataacaa ggtacaggag   540
tccgtatcag gtatcaaagt gaccaagtct ttcggttatc aggcagacga gttgaagtct   600
tttcaggcag tcaatgaatt aaccttccaa aagaacctgc aaaccatgaa atatgatagt   660
ctctttgacc ctatggttct cttgtttgtt ggttcgtcct atgttttaac gcttttggtt   720
ggctccttga tggttcagga agggcagatt acagttggga atctagtcac ctttatcagc   780
tatttggata tgctggtctg gcctcttctg gccatcggtt tcctctttaa tactactcag   840
cgagggaagg tttcttacca gcggattgaa aatcttttgt ctcaggaatc tcctgtacaa   900
gaccctgagt ttcctctgga tggtattgaa aatgggcgtt tggagtatgc cattgacagc   960
tttgcttttg aaaatgagga aacactgacg gatattcact ttagtttggc aaaagggcaa   1020
acactgggct tggttgggca gacaggctct gggaaaacgt ccttaatcaa gctcctcttg   1080
cgtgaatacg atgtggataa gggtgccatt tatctaaacg gtcacgatat tcgggactat   1140
cgtctgacag accttcgcag tctcatgggc tatgttcctc aggaccagtt tctttttgcg   1200
acttcaatcc tagacaatat ccgctttggc aatcctaact tgcccctttc agcggtcgag   1260
gaagctacta agctagcccg ggtttaccaa gatattgtag acatgcctca aggatttgat   1320
acgctgattg gtgaaaaagg agtcagtctt tctggtggtc aaaagcaacg gttggctatg   1380
agtcgggcta tgattttaga ccctgatatc ttgattttgg atgattcctt atccgccgta   1440
gatgccaaga cagagtatgc gattatcgac aacctcaagg agatgcgaaa ggacaagaca   1500
accattatca ctgcccatcg cctcagtgct gttgtccatg cagattttat tttagttcta   1560
caaaatggtc aaattatcga acgaggcacg cacgaagact tgctagcttt ggatggctgg   1620
tatgcccaaa cctaccagtc tcagcagttg gaaatgaaag gagaagaaga tgcagaa      1677

<210>   3806
<211>   559
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903699 (0.E+01)

<400>   3806
Met Ala Leu Ile Leu Val Ser Val Leu Asn Leu Ile Pro Pro Met Val 
1               5                   10                  15      

Met Gly Arg Val Ile Asp Ala Ile Thr Ser Gly Gln Leu Thr Gln Gln 
            20                  25                  30          

Asp Leu Leu Leu Ser Leu Phe Tyr Leu Leu Leu Ala Ala Phe Gly Met 
        35                  40                  45              

Tyr Tyr Leu Arg Tyr Val Trp Arg Met Tyr Ile Leu Gly Thr Ser Tyr 
    50                  55                  60                  

Cys Leu Gly Gln Ile Met Arg Ser Arg Leu Phe Lys His Phe Thr Lys 
65                  70                  75                  80  

Met Ser Ser Ala Phe Tyr Gln Thr Tyr Arg Thr Gly Asp Leu Met Ala 
                85                  90                  95      

His Ala Thr Asn Asp Ile Asn Ala Leu Thr Arg Leu Ala Gly Gly Gly 
            100                 105                 110         

Val Met Ser Ala Val Asp Ala Ser Ile Thr Ala Leu Val Thr Leu Leu 
        115                 120                 125             

Thr Met Leu Phe Ser Ile Ser Trp Gln Met Thr Leu Val Ala Ile Leu 
    130                 135                 140                 

Pro Leu Pro Phe Met Ala Tyr Thr Thr Ser Arg Leu Gly Arg Lys Thr 
145                 150                 155                 160 

His Lys Ala Phe Gly Glu Ser Gln Ala Ala Phe Ser Glu Leu Asn Asn 
                165                 170                 175     

Lys Val Gln Glu Ser Val Ser Gly Ile Lys Val Thr Lys Ser Phe Gly 
            180                 185                 190         

Tyr Gln Ala Asp Glu Leu Lys Ser Phe Gln Ala Val Asn Glu Leu Thr 
        195                 200                 205             

Phe Gln Lys Asn Leu Gln Thr Met Lys Tyr Asp Ser Leu Phe Asp Pro 
    210                 215                 220                 

Met Val Leu Leu Phe Val Gly Ser Ser Tyr Val Leu Thr Leu Leu Val 
225                 230                 235                 240 

Gly Ser Leu Met Val Gln Glu Gly Gln Ile Thr Val Gly Asn Leu Val 
                245                 250                 255     

Thr Phe Ile Ser Tyr Leu Asp Met Leu Val Trp Pro Leu Leu Ala Ile 
            260                 265                 270         

Gly Phe Leu Phe Asn Thr Thr Gln Arg Gly Lys Val Ser Tyr Gln Arg 
        275                 280                 285             

Ile Glu Asn Leu Leu Ser Gln Glu Ser Pro Val Gln Asp Pro Glu Phe 
    290                 295                 300                 

Pro Leu Asp Gly Ile Glu Asn Gly Arg Leu Glu Tyr Ala Ile Asp Ser 
305                 310                 315                 320 

Phe Ala Phe Glu Asn Glu Glu Thr Leu Thr Asp Ile His Phe Ser Leu 
                325                 330                 335     

Ala Lys Gly Gln Thr Leu Gly Leu Val Gly Gln Thr Gly Ser Gly Lys 
            340                 345                 350         

Thr Ser Leu Ile Lys Leu Leu Leu Arg Glu Tyr Asp Val Asp Lys Gly 
        355                 360                 365             

Ala Ile Tyr Leu Asn Gly His Asp Ile Arg Asp Tyr Arg Leu Thr Asp 
    370                 375                 380                 

Leu Arg Ser Leu Met Gly Tyr Val Pro Gln Asp Gln Phe Leu Phe Ala 
385                 390                 395                 400 

Thr Ser Ile Leu Asp Asn Ile Arg Phe Gly Asn Pro Asn Leu Pro Leu 
                405                 410                 415     

Ser Ala Val Glu Glu Ala Thr Lys Leu Ala Arg Val Tyr Gln Asp Ile 
            420                 425                 430         

Val Asp Met Pro Gln Gly Phe Asp Thr Leu Ile Gly Glu Lys Gly Val 
        435                 440                 445             

Ser Leu Ser Gly Gly Gln Lys Gln Arg Leu Ala Met Ser Arg Ala Met 
    450                 455                 460                 

Ile Leu Asp Pro Asp Ile Leu Ile Leu Asp Asp Ser Leu Ser Ala Val 
465                 470                 475                 480 

Asp Ala Lys Thr Glu Tyr Ala Ile Ile Asp Asn Leu Lys Glu Met Arg 
                485                 490                 495     

Lys Asp Lys Thr Thr Ile Ile Thr Ala His Arg Leu Ser Ala Val Val 
            500                 505                 510         

His Ala Asp Phe Ile Leu Val Leu Gln Asn Gly Gln Ile Ile Glu Arg 
        515                 520                 525             

Gly Thr His Glu Asp Leu Leu Ala Leu Asp Gly Trp Tyr Ala Gln Thr 
    530                 535                 540                 

Tyr Gln Ser Gln Gln Leu Glu Met Lys Gly Glu Glu Asp Ala Glu 
545                 550                 555                 

<210>   3807
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3807
ttgattttca ttgagtattg gcctcaggtt tccatttgca atcagaaagg gattttatgt   60
ccattattca aaaactttgg tggtttttca agt                                93

<210>   3808
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3808
Met Ile Phe Ile Glu Tyr Trp Pro Gln Val Ser Ile Cys Asn Gln Lys 
1               5                   10                  15      

Gly Ile Leu Cys Pro Leu Phe Lys Asn Phe Gly Gly Phe Ser Ser 
            20                  25                  30      

<210>   3809
<211>   375
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3809
gtgaaacgtt tgattgatgg taagccaact ctccttatca aaaatgggaa tattgaccca   60
gaagcctgtc gttcagttgg tttgtctgca tcggatgtat ccctcaaact tcgtagccaa   120
gggattttcc agatgaagca agtcaaacga gctgtgcaag agcaaaatgg gcaactcatc   180
gttgtgcaaa tgggagatga aaatcctaag tatccagttg tgactgacgg tgtgattcaa   240
gtagatgtct tggaatcgat tggtcgtagc gaagagtggt tgcttgataa cctcagtaaa   300
caagggcatg acaatgtagc caatatcttt attgctgaat atgacaaggg tgctgttaca   360
gtcgtaactt atgaa                                                    375

<210>   3810
<211>   125
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903700 (8.E-67)

<400>   3810
Met Lys Arg Leu Ile Asp Gly Lys Pro Thr Leu Leu Ile Lys Asn Gly 
1               5                   10                  15      

Asn Ile Asp Pro Glu Ala Cys Arg Ser Val Gly Leu Ser Ala Ser Asp 
            20                  25                  30          

Val Ser Leu Lys Leu Arg Ser Gln Gly Ile Phe Gln Met Lys Gln Val 
        35                  40                  45              

Lys Arg Ala Val Gln Glu Gln Asn Gly Gln Leu Ile Val Val Gln Met 
    50                  55                  60                  

Gly Asp Glu Asn Pro Lys Tyr Pro Val Val Thr Asp Gly Val Ile Gln 
65                  70                  75                  80  

Val Asp Val Leu Glu Ser Ile Gly Arg Ser Glu Glu Trp Leu Leu Asp 
                85                  90                  95      

Asn Leu Ser Lys Gln Gly His Asp Asn Val Ala Asn Ile Phe Ile Ala 
            100                 105                 110         

Glu Tyr Asp Lys Gly Ala Val Thr Val Val Thr Tyr Glu 
        115                 120                 125 

<210>   3811
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3811
gtgggagatc gctattatcg tgccctaaat ggaagtgagc cagacaagta cctgttagag   60
aaagtcgaat tgtataagac agacgcaatt gaactggtgg atgtgaacaa a            111

<210>   3812
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903701 (1.E-16)

<400>   3812
Met Gly Asp Arg Tyr Tyr Arg Ala Leu Asn Gly Ser Glu Pro Asp Lys 
1               5                   10                  15      

Tyr Leu Leu Glu Lys Val Glu Leu Tyr Lys Thr Asp Ala Ile Glu Leu 
            20                  25                  30          

Val Asp Val Asn Lys 
        35          

<210>   3813
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3813
ttggtcagca tcacgactta tcaaaacaat caagtttcta acaataaatt tcaaacttca   60
cttcatttca tcgaggttgt ttccaaagat ttg                                93

<210>   3814
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903701 (6.E-13)

<400>   3814
Met Val Ser Ile Thr Thr Tyr Gln Asn Asn Gln Val Ser Asn Asn Lys 
1               5                   10                  15      

Phe Gln Thr Ser Leu His Phe Ile Glu Val Val Ser Lys Asp Leu 
            20                  25                  30      

<210>   3815
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3815
atgaaattct actcttatga ctatgtactc agccaaatcg gtcagcaaaa tggtatcatg   60
gttggctttg ggattgttct attagctgtg acagtttttt ttgctttcaa ggcataccat   120
aataaaaagg gaagcgaatt tcgtgagttg gtcatgattt cagatctggc cttatttagc   180
tctgcttttg gtcagcatca cgacttatca aaacaatcaa gtttc                   225

<210>   3816
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside

<400>   3816
Met Lys Phe Tyr Ser Tyr Asp Tyr Val Leu Ser Gln Ile Gly Gln Gln 
1               5                   10                  15      

Asn Gly Ile Met Val Gly Phe Gly Ile Val Leu Leu Ala Val Thr Val 
            20                  25                  30          

Phe Phe Ala Phe Lys Ala Tyr His Asn Lys Lys Gly Ser Glu Phe Arg 
        35                  40                  45              

Glu Leu Val Met Ile Ser Asp Leu Ala Leu Phe Ser Ser Ala Phe Gly 
    50                  55                  60                  

Gln His His Asp Leu Ser Lys Gln Ser Ser Phe 
65                  70                  75  

<210>   3817
<211>   825
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3817
atgaaactta tctcatggaa tattgattcc ctaaacgctg ccctaactag tgactcagct   60
cgtgccaaat tgtcccaaga agtcctacaa accttggtcg ctgaaaatgc tgatatcatt   120
gctatccaag aaaccaagct ttctgccaaa ggacctacaa agaaacacgt ggaaatttta   180
gaagaactct tcccaggcta cgaaaacacg tggcgctctt cccaagagcc tgcccgtaaa   240
ggctatgctg gaaccatgtt cctttataag aaagaactta cacctactat cagcttccca   300
gaaatcggtg ccccttctac catggacttg gaaggtcgta tcatcactct agaatttgat   360
gcatttttcg taacccaagt ttacactcca aacgctggtg acggtctcaa acgcttggaa   420
gaacgccaag tctgggatgc caaatatgct gagtatttgg ctgaactaga caaagaaaaa   480
ccagtccttg cgaccggtga ctacaacgta gcccacaatg aaatcgacct tgcaaatcct   540
gctagcaacc gccgttcacc tggatttact gacgaggaac gtgctggatt taccaacctt   600
ttggcaactg gatttacaga caccttccgc catgttcatg gcgatgttcc tgaacgctac   660
acttggtggg cacaacgcag caaaacttct aaaatcaaca atacaggctg gagaatcgac   720
tactggctca caagtaaccg tatcgctgac aaggtcacta aatctgatat gattgactca   780
ggtgctcgcc aagaccatac accgattgtc ttggaaattg acttg                   825

<210>   3818
<211>   275
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   exodeoxyribonuclease (exoA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903702 (e-160)

<400>   3818
Met Lys Leu Ile Ser Trp Asn Ile Asp Ser Leu Asn Ala Ala Leu Thr 
1               5                   10                  15      

Ser Asp Ser Ala Arg Ala Lys Leu Ser Gln Glu Val Leu Gln Thr Leu 
            20                  25                  30          

Val Ala Glu Asn Ala Asp Ile Ile Ala Ile Gln Glu Thr Lys Leu Ser 
        35                  40                  45              

Ala Lys Gly Pro Thr Lys Lys His Val Glu Ile Leu Glu Glu Leu Phe 
    50                  55                  60                  

Pro Gly Tyr Glu Asn Thr Trp Arg Ser Ser Gln Glu Pro Ala Arg Lys 
65                  70                  75                  80  

Gly Tyr Ala Gly Thr Met Phe Leu Tyr Lys Lys Glu Leu Thr Pro Thr 
                85                  90                  95      

Ile Ser Phe Pro Glu Ile Gly Ala Pro Ser Thr Met Asp Leu Glu Gly 
            100                 105                 110         

Arg Ile Ile Thr Leu Glu Phe Asp Ala Phe Phe Val Thr Gln Val Tyr 
        115                 120                 125             

Thr Pro Asn Ala Gly Asp Gly Leu Lys Arg Leu Glu Glu Arg Gln Val 
    130                 135                 140                 

Trp Asp Ala Lys Tyr Ala Glu Tyr Leu Ala Glu Leu Asp Lys Glu Lys 

145                 150                 155                 160 

Pro Val Leu Ala Thr Gly Asp Tyr Asn Val Ala His Asn Glu Ile Asp 
                165                 170                 175     

Leu Ala Asn Pro Ala Ser Asn Arg Arg Ser Pro Gly Phe Thr Asp Glu 
            180                 185                 190         

Glu Arg Ala Gly Phe Thr Asn Leu Leu Ala Thr Gly Phe Thr Asp Thr 
        195                 200                 205             

Phe Arg His Val His Gly Asp Val Pro Glu Arg Tyr Thr Trp Trp Ala 
    210                 215                 220                 

Gln Arg Ser Lys Thr Ser Lys Ile Asn Asn Thr Gly Trp Arg Ile Asp 
225                 230                 235                 240 

Tyr Trp Leu Thr Ser Asn Arg Ile Ala Asp Lys Val Thr Lys Ser Asp 
                245                 250                 255     

Met Ile Asp Ser Gly Ala Arg Gln Asp His Thr Pro Ile Val Leu Glu 
            260                 265                 270         

Ile Asp Leu 
        275 

<210>   3819
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3819
atggactaca atgcggtcat tcccgagttg cttgtatcga atatcgaaca gtcccggtcc   60
ttctactgtg gtttactggg ttttaggatt gaataccaac gtccagaaga aaactttctc   120
tttctcttga agagtgtcaa c                                             141

<210>   3820
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3820
Met Asp Tyr Asn Ala Val Ile Pro Glu Leu Leu Val Ser Asn Ile Glu 
1               5                   10                  15      

Gln Ser Arg Ser Phe Tyr Cys Gly Leu Leu Gly Phe Arg Ile Glu Tyr 
            20                  25                  30          

Gln Arg Pro Glu Glu Asn Phe Leu Phe Leu Leu Lys Ser Val Asn 
        35                  40                  45          

<210>   3821
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3821
atgttagagg agggaacaaa ggatcaacta gctgaactga cctatccctt tggtcgtgga   60
gtcaatctct cctttggcat aaaggatgtt tcaaaactct at                      102

<210>   3822
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3822
Met Leu Glu Glu Gly Thr Lys Asp Gln Leu Ala Glu Leu Thr Tyr Pro 
1               5                   10                  15      

Phe Gly Arg Gly Val Asn Leu Ser Phe Gly Ile Lys Asp Val Ser Lys 
            20                  25                  30          

Leu Tyr 
        

<210>   3823
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3823
atgaaggcaa actatcctat ttatcgtccc ttgaccaaaa gaaagtttcg tgtcagtgat   60
ccctatatct atcctcataa atttgcagtt ttggatccag atggctattt tttaagattt   120
agcgag                                                              126

<210>   3824
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, FRAMESHIFT POINT MUTATION

<400>   3824
Met Lys Ala Asn Tyr Pro Ile Tyr Arg Pro Leu Thr Lys Arg Lys Phe 
1               5                   10                  15      

Arg Val Ser Asp Pro Tyr Ile Tyr Pro His Lys Phe Ala Val Leu Asp 
            20                  25                  30          

Pro Asp Gly Tyr Phe Leu Arg Phe Ser Glu 
        35                  40          

<210>   3825
<211>   171
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3825
atgcctttta tgatggaaaa atcttctaat actcttcgaa aatctcttca agccacgtca   60
acgtcgcctt accgtaggta tatgatactg gctctgtcaa ttctatccac aacctcaaaa   120
cagtgttttg aggttgtgga tagcttccta gtttgctctt tgattttcat t            171

<210>   3826
<211>   57
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3826
Met Pro Phe Met Met Glu Lys Ser Ser Asn Thr Leu Arg Lys Ser Leu 
1               5                   10                  15      

Gln Ala Thr Ser Thr Ser Pro Tyr Arg Arg Tyr Met Ile Leu Ala Leu 
            20                  25                  30          

Ser Ile Leu Ser Thr Thr Ser Lys Gln Cys Phe Glu Val Val Asp Ser 
        35                  40                  45              

Phe Leu Val Cys Ser Leu Ile Phe Ile 
    50                  55          

<210>   3827
<211>   579
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3827
atgaaattat tagaagagcg catcctcaag gatgggcata tcttgggtga taacatcctc   60
aaggtagatt cctttttaac ccaccaagtt gactttagct tgatgcgaga gattggtaag   120
gtttttgcgg aaaaatttgc tactactggc attaccaagg tcgtaaccat tgaagcgtcg   180
ggtattgccc cagccgtttt tacagctgaa gccttaaacg ttcccatgat tttcgccaaa   240
aaagctaaga acatcaccat gaacgaaggc atcttaactg ctcaagtcta ctcctttacc   300
aagcaggtga ccagcaccgt ttctatcgct gaaaaattcc tctcaccaga ggacaaggtt   360
ttgattatcg acgatttcct tgctaatggc caagctgcta aaggcttgat tcaaatcatc   420
gaacaggccg gtgccacagt ccaagctatc ggtatcgtga ttgagaaatc cttccaagat   480
ggtcgtgatt tgcttgaaaa agcaggctac cctgtcctat cacttgctcg tttggattgt   540
tttgaaaatg gtcaagtcgt atttaaggag gcagatctc                          579

<210>   3828
<211>   193
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   xanthine phosphoribosyltransferase (xpt)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903704 (e-100)

<400>   3828
Met Lys Leu Leu Glu Glu Arg Ile Leu Lys Asp Gly His Ile Leu Gly 
1               5                   10                  15      

Asp Asn Ile Leu Lys Val Asp Ser Phe Leu Thr His Gln Val Asp Phe 
            20                  25                  30          

Ser Leu Met Arg Glu Ile Gly Lys Val Phe Ala Glu Lys Phe Ala Thr 
        35                  40                  45              

Thr Gly Ile Thr Lys Val Val Thr Ile Glu Ala Ser Gly Ile Ala Pro 
    50                  55                  60                  

Ala Val Phe Thr Ala Glu Ala Leu Asn Val Pro Met Ile Phe Ala Lys 
65                  70                  75                  80  

Lys Ala Lys Asn Ile Thr Met Asn Glu Gly Ile Leu Thr Ala Gln Val 
                85                  90                  95      

Tyr Ser Phe Thr Lys Gln Val Thr Ser Thr Val Ser Ile Ala Glu Lys 
            100                 105                 110         

Phe Leu Ser Pro Glu Asp Lys Val Leu Ile Ile Asp Asp Phe Leu Ala 
        115                 120                 125             

Asn Gly Gln Ala Ala Lys Gly Leu Ile Gln Ile Ile Glu Gln Ala Gly 
    130                 135                 140                 

Ala Thr Val Gln Ala Ile Gly Ile Val Ile Glu Lys Ser Phe Gln Asp 
145                 150                 155                 160 

Gly Arg Asp Leu Leu Glu Lys Ala Gly Tyr Pro Val Leu Ser Leu Ala 
                165                 170                 175     

Arg Leu Asp Cys Phe Glu Asn Gly Gln Val Val Phe Lys Glu Ala Asp 
            180                 185                 190         

Leu 
    

<210>   3829
<211>   1260
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3829
atgcaaactc aagaaaaaca ctcgcaagca gccgttcttg gcttgcagca cttactagcc   60
atgtactcag gatctatcct ggttcccatc atgattgcga cagcccttgg ctattcagct   120
gagcagttga cctacctgat ttctacagat atcttcatgt gtggggtggc aaccttcctc   180
caactccaac tcaacaaata ctttgggatt ggactcccag tcgttcttgg agttgcattc   240
cagtcggtcg ctcccttgat tatgattggg caaagccatg gtagtggcgc tatgtttggt   300
gcccttatcg catctgggat ttacgtggtt cttgtttcag gcatcttctc aaaagtagcc   360
aatctcttcc catctatcgt aacaggatct gttattacca cgattggttt aaccttgatc   420
cctgtcgcta ttggaaatat gggaaataac gttccagagc caactggtca aagtctcttg   480
cttgcagcta ttactgttct gattatcctc ttgatcaaca tctttaccaa aggatttatc   540
aagtctatct ctattttgat tggtctggtt gttggaactg ccattgctgc tactatgggc   600
ttggtggact tctctcctgt tgcggtagct ccacttgtcc atgtcccaac tccactctac   660
tttgggatgc caacctttga aatctcatct attgtcatga tgtgtatcat cgcaacggtg   720
tctatggttg agtcaactgg tgtttatctg gccttgtctg atatcacaaa ggatccaatc   780
gacagcacgc gccttcgcaa cggataccgc gcagaaggtt tggccgtact tctcggagga   840
atctttaaca ccttccctta caccggattt tcacaaaacg ttggtttggt taaattgtca   900
ggcatcaaaa aacgcctgcc aatctactac gcagctggtt tcctggttct ccttggactg   960
cttcctaagt ttggcgccct tgcccaaatc attccaagct ccgtcctcgg tggtgccatg   1020
ctggtaatgt ttggttttgt atcaattcaa gggatgcaaa tcctcgcccg tgttgacttt   1080
gctaacaatg aacacaactt ccttatcgca gctgtttcaa tcgctgcagg tgtcggtctc   1140
aacaacagta atctctttgt cagcatgccg acagccttcc aaatgttctt ctcaaacgga   1200
atcgtcgtag ccagcctact cgctattgtc ctcaatgccg tattaaatca taaaaagaaa   1260

<210>   3830
<211>   420
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   xanthine permease (pbuX)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903705 (0.E+01)

<400>   3830
Met Gln Thr Gln Glu Lys His Ser Gln Ala Ala Val Leu Gly Leu Gln 
1               5                   10                  15      

His Leu Leu Ala Met Tyr Ser Gly Ser Ile Leu Val Pro Ile Met Ile 
            20                  25                  30          

Ala Thr Ala Leu Gly Tyr Ser Ala Glu Gln Leu Thr Tyr Leu Ile Ser 
        35                  40                  45              

Thr Asp Ile Phe Met Cys Gly Val Ala Thr Phe Leu Gln Leu Gln Leu 
    50                  55                  60                  

Asn Lys Tyr Phe Gly Ile Gly Leu Pro Val Val Leu Gly Val Ala Phe 
65                  70                  75                  80  

Gln Ser Val Ala Pro Leu Ile Met Ile Gly Gln Ser His Gly Ser Gly 
                85                  90                  95      

Ala Met Phe Gly Ala Leu Ile Ala Ser Gly Ile Tyr Val Val Leu Val 
            100                 105                 110         

Ser Gly Ile Phe Ser Lys Val Ala Asn Leu Phe Pro Ser Ile Val Thr 
        115                 120                 125             

Gly Ser Val Ile Thr Thr Ile Gly Leu Thr Leu Ile Pro Val Ala Ile 
    130                 135                 140                 

Gly Asn Met Gly Asn Asn Val Pro Glu Pro Thr Gly Gln Ser Leu Leu 
145                 150                 155                 160 

Leu Ala Ala Ile Thr Val Leu Ile Ile Leu Leu Ile Asn Ile Phe Thr 
                165                 170                 175     

Lys Gly Phe Ile Lys Ser Ile Ser Ile Leu Ile Gly Leu Val Val Gly 
            180                 185                 190         

Thr Ala Ile Ala Ala Thr Met Gly Leu Val Asp Phe Ser Pro Val Ala 
        195                 200                 205             

Val Ala Pro Leu Val His Val Pro Thr Pro Leu Tyr Phe Gly Met Pro 
    210                 215                 220                 

Thr Phe Glu Ile Ser Ser Ile Val Met Met Cys Ile Ile Ala Thr Val 
225                 230                 235                 240 

Ser Met Val Glu Ser Thr Gly Val Tyr Leu Ala Leu Ser Asp Ile Thr 
                245                 250                 255     

Lys Asp Pro Ile Asp Ser Thr Arg Leu Arg Asn Gly Tyr Arg Ala Glu 
            260                 265                 270         

Gly Leu Ala Val Leu Leu Gly Gly Ile Phe Asn Thr Phe Pro Tyr Thr 
        275                 280                 285             

Gly Phe Ser Gln Asn Val Gly Leu Val Lys Leu Ser Gly Ile Lys Lys 
    290                 295                 300                 

Arg Leu Pro Ile Tyr Tyr Ala Ala Gly Phe Leu Val Leu Leu Gly Leu 
305                 310                 315                 320 

Leu Pro Lys Phe Gly Ala Leu Ala Gln Ile Ile Pro Ser Ser Val Leu 
                325                 330                 335     

Gly Gly Ala Met Leu Val Met Phe Gly Phe Val Ser Ile Gln Gly Met 
            340                 345                 350         

Gln Ile Leu Ala Arg Val Asp Phe Ala Asn Asn Glu His Asn Phe Leu 
        355                 360                 365             

Ile Ala Ala Val Ser Ile Ala Ala Gly Val Gly Leu Asn Asn Ser Asn 
    370                 375                 380                 

Leu Phe Val Ser Met Pro Thr Ala Phe Gln Met Phe Phe Ser Asn Gly 
385                 390                 395                 400 

Ile Val Val Ala Ser Leu Leu Ala Ile Val Leu Asn Ala Val Leu Asn 

                405                 410                 415     

His Lys Lys Lys 
            420 

<210>   3831
<211>   459
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3831
atgaaaacga aacaacttgt tgcatcagaa gaggtgtatg atttcttaaa agtcatctgg   60
cctgattatg aaactgaaag ccgttacgat aacctaagtt taatcgtctg taccttatca   120
gatcccgatt gtgtgagatg gttatctgaa aatatgaaat ttggtgacga aaaacaacta   180
gctttgatga aggaaaaata tgggtgggaa gtaggagata aattgccaga gtggctacat   240
agctcctatc atagattatt gttaataggt gaattattgg aaagcaatct aaaactgaaa   300
aagtatacag tagaaattac agaaacttta tcacgtttag taagtataga ggctgaaaat   360
ccagatgaag ccgaacgact tgtaagagaa aagtataaga gttgtgaaat tgttcttgat   420
gcagatgatt ttcaggacta tgacactagc atatatgaa                          459

<210>   3832
<211>   153
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DpnD protein (dpnD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903706 (2.E-87)

<400>   3832
Met Lys Thr Lys Gln Leu Val Ala Ser Glu Glu Val Tyr Asp Phe Leu 
1               5                   10                  15      

Lys Val Ile Trp Pro Asp Tyr Glu Thr Glu Ser Arg Tyr Asp Asn Leu 
            20                  25                  30          

Ser Leu Ile Val Cys Thr Leu Ser Asp Pro Asp Cys Val Arg Trp Leu 
        35                  40                  45              

Ser Glu Asn Met Lys Phe Gly Asp Glu Lys Gln Leu Ala Leu Met Lys 
    50                  55                  60                  

Glu Lys Tyr Gly Trp Glu Val Gly Asp Lys Leu Pro Glu Trp Leu His 
65                  70                  75                  80  

Ser Ser Tyr His Arg Leu Leu Leu Ile Gly Glu Leu Leu Glu Ser Asn 
                85                  90                  95      

Leu Lys Leu Lys Lys Tyr Thr Val Glu Ile Thr Glu Thr Leu Ser Arg 
            100                 105                 110         

Leu Val Ser Ile Glu Ala Glu Asn Pro Asp Glu Ala Glu Arg Leu Val 
        115                 120                 125             

Arg Glu Lys Tyr Lys Ser Cys Glu Ile Val Leu Asp Ala Asp Asp Phe 
    130                 135                 140                 

Gln Asp Tyr Asp Thr Ser Ile Tyr Glu 
145                 150             

<210>   3833
<211>   762
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3833
atggaattac attttaattt agaattagta gaaacctata aaagtaatag ccaaaaggca   60
cgtatcttaa cggaggattg ggtttatcgt cagtcttatt gccctaattg tgggaacaat   120
cccttaaatc attttgaaaa taatcggcct gtagcagatt tttactgtaa tcattgtagt   180
gaggagtttg aactaaagag caaaaaagga aatttttcat caacaatcaa tgatggtgct   240
tatgcaacga tgatgaagcg tgtgcaggca gataataatc ctaatttctt ttttttaact   300
tacacaaaaa attttgaggt aaataacttt cttgtccttc cgaagcaatt tgttacaccg   360
aaatcgatta ttcaaagaaa accacttgca ccaactgcta gacgagcagg ttggattggt   420
tgtaacattg atttatcaca agtaccttct aaaggaagga tatttcttgt gcaagatgga   480
caagttagag atccagaaaa agttacaaaa gaatttaagc aaggtttatt tttaaggaag   540
agctctctgt catcaagagg ttggacaata gaaattctaa attgtataga taagatagag   600
ggttcagaat ttacccttga agatatgtat cgttttgaaa gtgacctaaa aaatatcttt   660
gttaagaaca atcatatcaa agaaaagatt aggcaacagc ttcaaatatt aagagacaaa   720
gaaataatag aatttaaagg tagaggaaag tatcggaaat ta                      762

<210>   3834
<211>   254
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type II restriction endonuclease DpnI (dpnC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903707 (e-150)

<400>   3834
Met Glu Leu His Phe Asn Leu Glu Leu Val Glu Thr Tyr Lys Ser Asn 
1               5                   10                  15      

Ser Gln Lys Ala Arg Ile Leu Thr Glu Asp Trp Val Tyr Arg Gln Ser 
            20                  25                  30          

Tyr Cys Pro Asn Cys Gly Asn Asn Pro Leu Asn His Phe Glu Asn Asn 
        35                  40                  45              

Arg Pro Val Ala Asp Phe Tyr Cys Asn His Cys Ser Glu Glu Phe Glu 
    50                  55                  60                  

Leu Lys Ser Lys Lys Gly Asn Phe Ser Ser Thr Ile Asn Asp Gly Ala 
65                  70                  75                  80  

Tyr Ala Thr Met Met Lys Arg Val Gln Ala Asp Asn Asn Pro Asn Phe 
                85                  90                  95      

Phe Phe Leu Thr Tyr Thr Lys Asn Phe Glu Val Asn Asn Phe Leu Val 
            100                 105                 110         

Leu Pro Lys Gln Phe Val Thr Pro Lys Ser Ile Ile Gln Arg Lys Pro 
        115                 120                 125             

Leu Ala Pro Thr Ala Arg Arg Ala Gly Trp Ile Gly Cys Asn Ile Asp 
    130                 135                 140                 

Leu Ser Gln Val Pro Ser Lys Gly Arg Ile Phe Leu Val Gln Asp Gly 
145                 150                 155                 160 

Gln Val Arg Asp Pro Glu Lys Val Thr Lys Glu Phe Lys Gln Gly Leu 
                165                 170                 175     

Phe Leu Arg Lys Ser Ser Leu Ser Ser Arg Gly Trp Thr Ile Glu Ile 
            180                 185                 190         

Leu Asn Cys Ile Asp Lys Ile Glu Gly Ser Glu Phe Thr Leu Glu Asp 
        195                 200                 205             

Met Tyr Arg Phe Glu Ser Asp Leu Lys Asn Ile Phe Val Lys Asn Asn 
    210                 215                 220                 

His Ile Lys Glu Lys Ile Arg Gln Gln Leu Gln Ile Leu Arg Asp Lys 
225                 230                 235                 240 

Glu Ile Ile Glu Phe Lys Gly Arg Gly Lys Tyr Arg Lys Leu 
                245                 250                 

<210>   3835
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3835
ttggcctgtg acaaacatgg taaaggttgc tttgcagaca tttctgccct cttgattggt   60
gatatccaca tccattacac aagttgtacg accttgatgg acacattctc ctttaatggt   120
caatacatcg tcgagttttc ctgccttaag gtagttgata gaggattgga gtgtcacccc   180
atcaagtccc agcgagataa ccaccaaacc actgatttgg tcaca                   225

<210>   3836
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3836
Met Ala Cys Asp Lys His Gly Lys Gly Cys Phe Ala Asp Ile Ser Ala 
1               5                   10                  15      

Leu Leu Ile Gly Asp Ile His Ile His Tyr Thr Ser Cys Thr Thr Leu 
            20                  25                  30          

Met Asp Thr Phe Ser Phe Asn Gly Gln Tyr Ile Val Glu Phe Ser Cys 
        35                  40                  45              

Leu Lys Val Val Asp Arg Gly Leu Glu Cys His Pro Ile Lys Ser Gln 
    50                  55                  60                  

Arg Asp Asn His Gln Thr Thr Asp Leu Val Thr 
65                  70                  75  

<210>   3837
<211>   402
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3837
atgaaagact ttcattttga cgctatatct gcctttgaaa attacgaaat tgaaaaaatg   60
agagatggtc acgttgtggt gacgaccaaa gtagtgaact cgtcgctcaa ctactatggc   120
aatgcccatg gtggctatct attcacgcta tgtgaccaaa tcagtggttt ggtggttatc   180
tcgctgggac ttgatggggt gacactccaa tcctctatca actaccttaa ggcaggaaaa   240
ctcgacgatg tattgaccat taaaggagaa tgtgtccatc aaggtcgtac aacttgtgta   300
atggatgtgg atatcaccaa tcaagagggc agaaatgtct gcaaagcaac ctttaccatg   360
tttgtcacag gccaaaggtc tgaggaaaga cgggtaagga ta                      402

<210>   3838
<211>   134
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903708 (2.E-74)

<400>   3838
Met Lys Asp Phe His Phe Asp Ala Ile Ser Ala Phe Glu Asn Tyr Glu 
1               5                   10                  15      

Ile Glu Lys Met Arg Asp Gly His Val Val Val Thr Thr Lys Val Val 
            20                  25                  30          

Asn Ser Ser Leu Asn Tyr Tyr Gly Asn Ala His Gly Gly Tyr Leu Phe 
        35                  40                  45              

Thr Leu Cys Asp Gln Ile Ser Gly Leu Val Val Ile Ser Leu Gly Leu 
    50                  55                  60                  

Asp Gly Val Thr Leu Gln Ser Ser Ile Asn Tyr Leu Lys Ala Gly Lys 
65                  70                  75                  80  

Leu Asp Asp Val Leu Thr Ile Lys Gly Glu Cys Val His Gln Gly Arg 
                85                  90                  95      

Thr Thr Cys Val Met Asp Val Asp Ile Thr Asn Gln Glu Gly Arg Asn 
            100                 105                 110         

Val Cys Lys Ala Thr Phe Thr Met Phe Val Thr Gly Gln Arg Ser Glu 
        115                 120                 125             

Glu Arg Arg Val Arg Ile 
    130                 

<210>   3839
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3839
gtgggtgcta tctttgcgcg tgtacttgag gatgcaggag tctacaagca gacagaacaa   60
gggcagacag cctttatgcg ctttgtggaa caggtcggaa ttttactaga c            111

<210>   3840
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   galactose-1-phosphate uridylyltransferase-related

<400>   3840
Met Gly Ala Ile Phe Ala Arg Val Leu Glu Asp Ala Gly Val Tyr Lys 
1               5                   10                  15      

Gln Thr Glu Gln Gly Gln Thr Ala Phe Met Arg Phe Val Glu Gln Val 
            20                  25                  30          

Gly Ile Leu Leu Asp 
        35          

<210>   3841
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3841
ttggtctgcc cactcctgat gataatcggc aactgtaaca gcttctccta caagatagct   60
agcgacttgc tccacttctt ctttcagacg tggtggcaag attgccaagc ccatgacctc   120
aatcaagccg atattttcct tcttgatatg ttggacatcc ttgtggggat gatagatacc   180
atcaggatac tctgc                                                    195

<210>   3842
<211>   65
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3842
Met Val Cys Pro Leu Leu Met Ile Ile Gly Asn Cys Asn Ser Phe Ser 
1               5                   10                  15      

Tyr Lys Ile Ala Ser Asp Leu Leu His Phe Phe Phe Gln Thr Trp Trp 
            20                  25                  30          

Gln Asp Cys Gln Ala His Asp Leu Asn Gln Ala Asp Ile Phe Leu Leu 
        35                  40                  45              

Asp Met Leu Asp Ile Leu Val Gly Met Ile Asp Thr Ile Arg Ile Leu 
    50                  55                  60                  

Cys 
65  

<210>   3843
<211>   1478
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3843
gtgaccttag taaataaatt tgtaacacat gtcatttctg aaagctcatt tgaggaaatg   60
gatcgaatct atctgaccaa tcgtgttttg gcacgagtgg gagaaggtgt tttggaagtt   120
gagaccaatc tggataaatt gattgacctc aaggaccagc tggttgaaga agccgttcga   180
ttagagacga ttgaggatag tcagactgcg cgtgaaatcc ttggtgctga actgatggat   240
ttggtgactc cttgtccaag tcaggtcaat cgtgattttt gggcaaccta cgcccactct   300
ccagaacaag cgatagagga tttttaccaa ctcagtcaga aaaatgacta catcaaactc   360
aaggccattg ctagaaatat cgcttatcgt gttccatctg actacggaga acttgaaatt   420
accatcaatc tctctaagcc tgaaaaagat cccaaagaga ttgtggcagc caagttggtg   480
caagctagta attatcctca gtgtcagctt tgtctagaga atgagggcta ccatggtcga   540
gttaaccacc cagctcgtag caatcaccgt attatccgtt ttgaaatggt tggtcaggaa   600
tggggtttcc agtattcgcc ctatgcttac tttaatgagc attgtatctt tttagatggc   660
cagcatcgtc ccatggccat tagtcgtcag agttttgaac gtctgttggc tatcgtagac   720
cagtttccag gatattttgc tggatctaat gccgacctgc cgattgtggg gggctctatt   780
ctaactcatg atcattatca gggaggccgt cacgtatttc ctatggaatt ggctcccttg   840
caaaaggcct tccgatttgc tggttttgag caggtcaagg ctggaattgt caagtggccc   900
atgtctgtcc tacgtttgac ttcggattcc aaagaggatt tgatcaattt ggctgataag   960
attttgcagg aatggcgcca gtattcagat cctgcagtgc agattttggc agagacagac   1020
aggacaccgc atcacactat cacacccatt gcccgcaaac gcgatggaca gtttgagttg   1080
gacttggtct tgcgagacaa tcagacttca gcagagtatc ctgatggtat ctatcatccc   1140
cacaaggatg tccaacatat caagaaggaa aatatcggct tgattgaggt catgggcttg   1200
gcaatcttgc caccacgtct gaaagaagaa gtggagcaag tcgctagcta tcttgtagga   1260
gaagctgtta cagttgccga ttatcatcag gagtgggcag accaactcaa atcccaacat   1320
ccagactaac ggataaagaa aaagcccttg caatcgtcaa ggactctgtg ggtgctatct   1380
ttgcgcgtgt acttgaggat gcaggagtct acaagcagac agaacaaggg cagacagcct   1440
ttatgcgctt tgtggaacag gtcggaattt tactagac                           1478

<210>   3844
<211>   442
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   galactose-1-phosphate uridylyltransferase FRAMESHIFT (galT)

<400>   3844
Met Thr Leu Val Asn Lys Phe Val Thr His Val Ile Ser Glu Ser Ser 
1               5                   10                  15      

Phe Glu Glu Met Asp Arg Ile Tyr Leu Thr Asn Arg Val Leu Ala Arg 
            20                  25                  30          

Val Gly Glu Gly Val Leu Glu Val Glu Thr Asn Leu Asp Lys Leu Ile 
        35                  40                  45              

Asp Leu Lys Asp Gln Leu Val Glu Glu Ala Val Arg Leu Glu Thr Ile 
    50                  55                  60                  

Glu Asp Ser Gln Thr Ala Arg Glu Ile Leu Gly Ala Glu Leu Met Asp 
65                  70                  75                  80  

Leu Val Thr Pro Cys Pro Ser Gln Val Asn Arg Asp Phe Trp Ala Thr 
                85                  90                  95      

Tyr Ala His Ser Pro Glu Gln Ala Ile Glu Asp Phe Tyr Gln Leu Ser 
            100                 105                 110         

Gln Lys Asn Asp Tyr Ile Lys Leu Lys Ala Ile Ala Arg Asn Ile Ala 
        115                 120                 125             

Tyr Arg Val Pro Ser Asp Tyr Gly Glu Leu Glu Ile Thr Ile Asn Leu 
    130                 135                 140                 

Ser Lys Pro Glu Lys Asp Pro Lys Glu Ile Val Ala Ala Lys Leu Val 
145                 150                 155                 160 

Gln Ala Ser Asn Tyr Pro Gln Cys Gln Leu Cys Leu Glu Asn Glu Gly 
                165                 170                 175     

Tyr His Gly Arg Val Asn His Pro Ala Arg Ser Asn His Arg Ile Ile 
            180                 185                 190         

Arg Phe Glu Met Val Gly Gln Glu Trp Gly Phe Gln Tyr Ser Pro Tyr 
        195                 200                 205             

Ala Tyr Phe Asn Glu His Cys Ile Phe Leu Asp Gly Gln His Arg Pro 
    210                 215                 220                 

Met Ala Ile Ser Arg Gln Ser Phe Glu Arg Leu Leu Ala Ile Val Asp 
225                 230                 235                 240 

Gln Phe Pro Gly Tyr Phe Ala Gly Ser Asn Ala Asp Leu Pro Ile Val 
                245                 250                 255     

Gly Gly Ser Ile Leu Thr His Asp His Tyr Gln Gly Gly Arg His Val 
            260                 265                 270         

Phe Pro Met Glu Leu Ala Pro Leu Gln Lys Ala Phe Arg Phe Ala Gly 
        275                 280                 285             

Phe Glu Gln Val Lys Ala Gly Ile Val Lys Trp Pro Met Ser Val Leu 
    290                 295                 300                 

Arg Leu Thr Ser Asp Ser Lys Glu Asp Leu Ile Asn Leu Ala Asp Lys 
305                 310                 315                 320 

Ile Leu Gln Glu Trp Arg Gln Tyr Ser Asp Pro Ala Val Gln Ile Leu 
                325                 330                 335     

Ala Glu Thr Asp Arg Thr Pro His His Thr Ile Thr Pro Ile Ala Arg 
            340                 345                 350         

Lys Arg Asp Gly Gln Phe Glu Leu Asp Leu Val Leu Arg Asp Asn Gln 
        355                 360                 365             

Thr Ser Ala Glu Tyr Pro Asp Gly Ile Tyr His Pro His Lys Asp Val 
    370                 375                 380                 

Gln His Ile Lys Lys Glu Asn Ile Gly Leu Ile Glu Val Met Gly Leu 
385                 390                 395                 400 

Ala Ile Leu Pro Pro Arg Leu Lys Glu Glu Val Glu Gln Val Ala Ser 
                405                 410                 415     

Tyr Leu Val Gly Glu Ala Val Thr Val Ala Asp Tyr His Gln Glu Trp 
            420                 425                 430         

Ala Asp Gln Leu Lys Ser Gln His Pro Asp 
        435                 440         

<210>   3845
<211>   1176
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3845
atggcacaac atcttactac tgaagccctt cgcaaagact ttcttgctgt ttttggtcaa   60
gaagcagatc aaaccttctt ttcaccaggc cgcattaatt tgattggtga acacacagac   120
tacaacggtg ggcacgtttt tcctgctgct atttccttgg gaacttacgg tgcagctcgt   180
aagcgtgacg accaagtctt gcgtttctac tcagctaact ttgaggacaa gggcattatc   240
gaagtgcctc tcgctgacct caagtttgaa aaagagcaca actggaccaa ttatccaaaa   300
ggtgtccttc atttcttgca agaagctggg cacgtgattg acaaaggttt tgatttttat   360
gtttatggaa atattccaaa tggtgctggc ttgtcttctt ctgcatcctt ggaactcttg   420
acaggagtcg tggctgagca tctctttgat ttaaaattag agcgtctcga tttggttaaa   480
atcggcaaac aaacagaaaa caactttatc ggagtaaact ctggcattat ggaccagttt   540
gctattggta tgggggcaga ccaacgtgct atttacctag atactaatac tttagaatac   600
gacttggtgc cacttgattt gaaggacaat gtcgttgtta tcatgaacac caacaaacgc   660
cgtgaattgg cggactctaa atacaatgaa cgtcgtgctg agtgtgaaaa agcagtggaa   720
gaattgcaag tttccttgga tattcagact ctgggtgaat tggacgagtg ggccgttgac   780
caatatagct atctgattaa agatgaaaat cgtttgaaac gtgctcgcca tgctgtgctt   840
gaaaaccaac gtaccctcaa agctcaagta gcactccaag caggagattt ggaaacattt   900
ggacgcttga tgaatgcgtc acacgtttct ctggagcatg attatgaagt aactggtttg   960
gaattggata cccttgttca cacagcttgg gcacaagaag gagttctcgg tgctcgtatg   1020
acaggggctg gttttggtgg ctgtgccatt gccttggttc aaaaagatac tgttgaggcc   1080
tttaaggaag ctgtaggcaa acactacgag gaagtagttg gatacgctcc aagcttctat   1140
atcgctgaag ttgcaggtgg cactcgcgtc cttgac                             1176

<210>   3846
<211>   392
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   galactokinase (galK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903709 (0.E+01)

<400>   3846
Met Ala Gln His Leu Thr Thr Glu Ala Leu Arg Lys Asp Phe Leu Ala 
1               5                   10                  15      

Val Phe Gly Gln Glu Ala Asp Gln Thr Phe Phe Ser Pro Gly Arg Ile 
            20                  25                  30          

Asn Leu Ile Gly Glu His Thr Asp Tyr Asn Gly Gly His Val Phe Pro 
        35                  40                  45              


Ala Ala Ile Ser Leu Gly Thr Tyr Gly Ala Ala Arg Lys Arg Asp Asp 
    50                  55                  60                  

Gln Val Leu Arg Phe Tyr Ser Ala Asn Phe Glu Asp Lys Gly Ile Ile 
65                  70                  75                  80  

Glu Val Pro Leu Ala Asp Leu Lys Phe Glu Lys Glu His Asn Trp Thr 
                85                  90                  95      

Asn Tyr Pro Lys Gly Val Leu His Phe Leu Gln Glu Ala Gly His Val 
            100                 105                 110         

Ile Asp Lys Gly Phe Asp Phe Tyr Val Tyr Gly Asn Ile Pro Asn Gly 
        115                 120                 125             

Ala Gly Leu Ser Ser Ser Ala Ser Leu Glu Leu Leu Thr Gly Val Val 
    130                 135                 140                 

Ala Glu His Leu Phe Asp Leu Lys Leu Glu Arg Leu Asp Leu Val Lys 
145                 150                 155                 160 

Ile Gly Lys Gln Thr Glu Asn Asn Phe Ile Gly Val Asn Ser Gly Ile 
                165                 170                 175     

Met Asp Gln Phe Ala Ile Gly Met Gly Ala Asp Gln Arg Ala Ile Tyr 
            180                 185                 190         

Leu Asp Thr Asn Thr Leu Glu Tyr Asp Leu Val Pro Leu Asp Leu Lys 
        195                 200                 205             

Asp Asn Val Val Val Ile Met Asn Thr Asn Lys Arg Arg Glu Leu Ala 
    210                 215                 220                 

Asp Ser Lys Tyr Asn Glu Arg Arg Ala Glu Cys Glu Lys Ala Val Glu 
225                 230                 235                 240 

Glu Leu Gln Val Ser Leu Asp Ile Gln Thr Leu Gly Glu Leu Asp Glu 
                245                 250                 255     

Trp Ala Val Asp Gln Tyr Ser Tyr Leu Ile Lys Asp Glu Asn Arg Leu 
            260                 265                 270         

Lys Arg Ala Arg His Ala Val Leu Glu Asn Gln Arg Thr Leu Lys Ala 
        275                 280                 285             

Gln Val Ala Leu Gln Ala Gly Asp Leu Glu Thr Phe Gly Arg Leu Met 
    290                 295                 300                 

Asn Ala Ser His Val Ser Leu Glu His Asp Tyr Glu Val Thr Gly Leu 
305                 310                 315                 320 

Glu Leu Asp Thr Leu Val His Thr Ala Trp Ala Gln Glu Gly Val Leu 
                325                 330                 335     

Gly Ala Arg Met Thr Gly Ala Gly Phe Gly Gly Cys Ala Ile Ala Leu 
            340                 345                 350         

Val Gln Lys Asp Thr Val Glu Ala Phe Lys Glu Ala Val Gly Lys His 
        355                 360                 365             

Tyr Glu Glu Val Val Gly Tyr Ala Pro Ser Phe Tyr Ile Ala Glu Val 
    370                 375                 380                 

Ala Gly Gly Thr Arg Val Leu Asp 
385                 390         

<210>   3847
<211>   1005
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3847
atggctacct taaaagacat tgcacagcta gcctctgtct ctatcgcgac cgtatcccgc   60
gtcctcaacc gcgaccagag cctatctgtt acagaagaaa ccagacaccg tattttaacc   120
gttgctgaag agctgggcta caccaagcac ctcaagacag gcgagtccca caaacccaag   180
caaaagattg ccattatcca atgggtcagc gaacaagggg agctggacga cctctactac   240
taccagattc gcctaggaat agaaaaaaga gcccaagagt tggactatga tatcttgcgc   300
tattttaatg accacccttt taccctaagc gaggaagtga ttgggattct ctgcatcgga   360
aagtttagtc gagctcagat ttctgccttt gaagaatacc aaaagcctct tgtatttcta   420
gacagcgata cactttccct gggacatacc tgtattatca cggattttta cactgctatg   480
aaacaggttg tcgattattt cctcagtcaa ggaatggacc gtatcgggat tctaacaggc   540
cttgaagaaa caacagacca agaagaaatc attcaggaca agcgtctaga aaacttcaaa   600
aactatagtc aagcgagggg aatctatcat gatgaactgg tctttcaagg aagatttact   660
gcccagtctg gctatgactt aatgaaggag gccattcaga gcttgggaga ccaacttccg   720
ccagcatttt tcgcagccag cgatagttta gctatcggtg ccctccgtgc cctccaagaa   780
gctggaatca gcctgccaga tcgcgtcagc ctcatttcct ttaacgacac tagtctgacc   840
aaacaggtct atcctcccct ctctagtatt acagtttata ctgaagaaat gggccgagca   900
ggtatggata ttcttaacaa ggaagtcctc cacggtcgga aaatccctag cctgaccatg   960
ctgggaacca gactgacatt aagagaaagt accctaaatc aagaa                   1005

<210>   3848
<211>   335
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   galactose operon repressor (galR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903711 (0.E+01)

<400>   3848
Met Ala Thr Leu Lys Asp Ile Ala Gln Leu Ala Ser Val Ser Ile Ala 
1               5                   10                  15      

Thr Val Ser Arg Val Leu Asn Arg Asp Gln Ser Leu Ser Val Thr Glu 
            20                  25                  30          

Glu Thr Arg His Arg Ile Leu Thr Val Ala Glu Glu Leu Gly Tyr Thr 
        35                  40                  45              

Lys His Leu Lys Thr Gly Glu Ser His Lys Pro Lys Gln Lys Ile Ala 
    50                  55                  60                  

Ile Ile Gln Trp Val Ser Glu Gln Gly Glu Leu Asp Asp Leu Tyr Tyr 
65                  70                  75                  80  

Tyr Gln Ile Arg Leu Gly Ile Glu Lys Arg Ala Gln Glu Leu Asp Tyr 
                85                  90                  95      

Asp Ile Leu Arg Tyr Phe Asn Asp His Pro Phe Thr Leu Ser Glu Glu 
            100                 105                 110         

Val Ile Gly Ile Leu Cys Ile Gly Lys Phe Ser Arg Ala Gln Ile Ser 
        115                 120                 125             

Ala Phe Glu Glu Tyr Gln Lys Pro Leu Val Phe Leu Asp Ser Asp Thr 
    130                 135                 140                 

Leu Ser Leu Gly His Thr Cys Ile Ile Thr Asp Phe Tyr Thr Ala Met 

145                 150                 155                 160 

Lys Gln Val Val Asp Tyr Phe Leu Ser Gln Gly Met Asp Arg Ile Gly 
                165                 170                 175     

Ile Leu Thr Gly Leu Glu Glu Thr Thr Asp Gln Glu Glu Ile Ile Gln 
            180                 185                 190         

Asp Lys Arg Leu Glu Asn Phe Lys Asn Tyr Ser Gln Ala Arg Gly Ile 
        195                 200                 205             

Tyr His Asp Glu Leu Val Phe Gln Gly Arg Phe Thr Ala Gln Ser Gly 
    210                 215                 220                 

Tyr Asp Leu Met Lys Glu Ala Ile Gln Ser Leu Gly Asp Gln Leu Pro 
225                 230                 235                 240 

Pro Ala Phe Phe Ala Ala Ser Asp Ser Leu Ala Ile Gly Ala Leu Arg 
                245                 250                 255     

Ala Leu Gln Glu Ala Gly Ile Ser Leu Pro Asp Arg Val Ser Leu Ile 
            260                 265                 270         

Ser Phe Asn Asp Thr Ser Leu Thr Lys Gln Val Tyr Pro Pro Leu Ser 
        275                 280                 285             

Ser Ile Thr Val Tyr Thr Glu Glu Met Gly Arg Ala Gly Met Asp Ile 
    290                 295                 300                 

Leu Asn Lys Glu Val Leu His Gly Arg Lys Ile Pro Ser Leu Thr Met 
305                 310                 315                 320 

Leu Gly Thr Arg Leu Thr Leu Arg Glu Ser Thr Leu Asn Gln Glu 
                325                 330                 335 

<210>   3849
<211>   1035
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3849
atgaaatcag cagtatatac aaaggcaggt caggttggac ttgctagcat tgaacgtccg   60
caaataatag aagcggatga tgtgattatt cgtgtggttc gtgcgtgcgt ttgtggttca   120
gatttatgga ggtaccgtaa tccagaaacg aaagctggac acaaaaatag tggacacgaa   180
gcgattggga ttgttgaaga agctggggaa gccattacga cggtgaaacc aggtgatttt   240
gtgattgtcc cttttacaca tggatgtggt gagtgtgatg cctgtcttgc tggatttgac   300
ggttcttgcg acaatcatat tggcaataat ttggggggtg attttcaggc agaatatatt   360
cgcttccact atgcaaactg ggcgctggtt aaaatccctg gtcaaccttc tgactataca   420
gaagggatgc tcaagtccct tttgactctt gcagatgtca tgccgacagg ctatcatgcg   480
gcgcgtgttg caaatgttca aaaaggggac aaggttgttg ttatcggtga tggggctgtt   540
ggtcaatgtg ctgtcatcgc ggctaagatg cgtggagcat cacaaattat ccttatgagc   600
cgtcatgaag accgtcaaaa gatggctatg gagtcaggtg cgacagctgt tgttgcagaa   660
cgtggtcaag aaggaattac caaggtgcgt gaaatcctcg gtggaggagc agatgcagca   720
cttgaatgtg ttggtacgga ggctgctata gaacaggcgc taggtgttct tcataatgga   780
gggcgtatgg gctttgtagg agtcccacac tataataatc gtgctcttgg ttcgacattt   840
atgcaaaata tctctgtagc aggtggggca gcttctgcta caacatacga taagcaattt   900
ttactaaaag ccgtccttga tggtgatatc aatccaggtc gcgtctttac ttcaagttat   960
aaactggaag atatcgacca agcctataaa gatatggatg aacgtaagac aattaagtct   1020
atgattgtaa tcgaa                                                    1035

<210>   3850
<211>   345
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alcohol dehydrogenase, zinc-containing
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903712 (0.E+01)

<400>   3850
Met Lys Ser Ala Val Tyr Thr Lys Ala Gly Gln Val Gly Leu Ala Ser 
1               5                   10                  15      

Ile Glu Arg Pro Gln Ile Ile Glu Ala Asp Asp Val Ile Ile Arg Val 
            20                  25                  30          

Val Arg Ala Cys Val Cys Gly Ser Asp Leu Trp Arg Tyr Arg Asn Pro 
        35                  40                  45              

Glu Thr Lys Ala Gly His Lys Asn Ser Gly His Glu Ala Ile Gly Ile 
    50                  55                  60                  

Val Glu Glu Ala Gly Glu Ala Ile Thr Thr Val Lys Pro Gly Asp Phe 
65                  70                  75                  80  

Val Ile Val Pro Phe Thr His Gly Cys Gly Glu Cys Asp Ala Cys Leu 
                85                  90                  95      

Ala Gly Phe Asp Gly Ser Cys Asp Asn His Ile Gly Asn Asn Leu Gly 
            100                 105                 110         

Gly Asp Phe Gln Ala Glu Tyr Ile Arg Phe His Tyr Ala Asn Trp Ala 
        115                 120                 125             

Leu Val Lys Ile Pro Gly Gln Pro Ser Asp Tyr Thr Glu Gly Met Leu 
    130                 135                 140                 

Lys Ser Leu Leu Thr Leu Ala Asp Val Met Pro Thr Gly Tyr His Ala 
145                 150                 155                 160 

Ala Arg Val Ala Asn Val Gln Lys Gly Asp Lys Val Val Val Ile Gly 
                165                 170                 175     

Asp Gly Ala Val Gly Gln Cys Ala Val Ile Ala Ala Lys Met Arg Gly 
            180                 185                 190         

Ala Ser Gln Ile Ile Leu Met Ser Arg His Glu Asp Arg Gln Lys Met 
        195                 200                 205             

Ala Met Glu Ser Gly Ala Thr Ala Val Val Ala Glu Arg Gly Gln Glu 
    210                 215                 220                 

Gly Ile Thr Lys Val Arg Glu Ile Leu Gly Gly Gly Ala Asp Ala Ala 
225                 230                 235                 240 

Leu Glu Cys Val Gly Thr Glu Ala Ala Ile Glu Gln Ala Leu Gly Val 
                245                 250                 255     

Leu His Asn Gly Gly Arg Met Gly Phe Val Gly Val Pro His Tyr Asn 
            260                 265                 270         

Asn Arg Ala Leu Gly Ser Thr Phe Met Gln Asn Ile Ser Val Ala Gly 
        275                 280                 285             

Gly Ala Ala Ser Ala Thr Thr Tyr Asp Lys Gln Phe Leu Leu Lys Ala 
    290                 295                 300                 

Val Leu Asp Gly Asp Ile Asn Pro Gly Arg Val Phe Thr Ser Ser Tyr 
305                 310                 315                 320 

Lys Leu Glu Asp Ile Asp Gln Ala Tyr Lys Asp Met Asp Glu Arg Lys 
                325                 330                 335     

Thr Ile Lys Ser Met Ile Val Ile Glu 
            340                 345 

<210>   3851
<211>   351
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3851
gtgaatatta aatctgccag tgatttgttg ggaatttcag cggatacgat tcggtattat   60
gaacgggttg gtcttgtgcc accgattact cgtactgcta ctgggattcg tgattttcaa   120
gatcaggata tcgaagcgct ggaatttatt aagtgttttc gttcggcggg tgtctctgta   180
gatagtttag ttgactatat gtcgctctac caaaagggag atgaaacgag agaggagagg   240
cttggtattt tagaagagga aaagcaaaaa ttagaggagc gcttgtctca gctacagaca   300
gctttaaatc gtttaaatct caaaattaaa ctttataagg aaggaaaatt t            351

<210>   3852
<211>   117
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, MerR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903713 (5.E-62)

<400>   3852
Met Asn Ile Lys Ser Ala Ser Asp Leu Leu Gly Ile Ser Ala Asp Thr 
1               5                   10                  15      

Ile Arg Tyr Tyr Glu Arg Val Gly Leu Val Pro Pro Ile Thr Arg Thr 
            20                  25                  30          

Ala Thr Gly Ile Arg Asp Phe Gln Asp Gln Asp Ile Glu Ala Leu Glu 
        35                  40                  45              

Phe Ile Lys Cys Phe Arg Ser Ala Gly Val Ser Val Asp Ser Leu Val 
    50                  55                  60                  

Asp Tyr Met Ser Leu Tyr Gln Lys Gly Asp Glu Thr Arg Glu Glu Arg 
65                  70                  75                  80  

Leu Gly Ile Leu Glu Glu Glu Lys Gln Lys Leu Glu Glu Arg Leu Ser 
                85                  90                  95      

Gln Leu Gln Thr Ala Leu Asn Arg Leu Asn Leu Lys Ile Lys Leu Tyr 
            100                 105                 110         

Lys Glu Gly Lys Phe 
        115         

<210>   3853
<211>   897
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3853
atgagaaata tgaaggcaaa atatgctgtt tgggtggctt ttttcttaaa tttgacttat   60
gccattgttg agtttattgc aggtggagta tttggttcta gcgctgttct tgctgactct   120
gtgcatgact tgggagatgc gattgcaatt ggaatatcag cttttctaga aacaatctcc   180
aatcgtgaag aagacaatca gtacaccttg ggctataagc ggtttagcct gctaggagcc   240
ttggtaacag ctgtgattct cgtaacgggc tctgttctag tcattttgga aaatgtcacg   300
aagattttgc atccgcaacc agtcaatgat gaggggattc tctggttagg aattattgcg   360
attactatca atctgttagc gagtctggtg gttggtaagg gaaagacaaa gaatgagtct   420
attctgagtc tgcattttct ggaagatacg ctagggtggg tagctgttat cctgatggcg   480
attgttcttc gatttacgga ctggtatatc ctagatcctc ttttgtccct tgtcatttct   540
ttctttattc tttcaaaagc ccttccacgt ttttggtcta cactcaagat tttcttggat   600
gctgtgccag aaggtcttga tatcaagcaa gtaaagagtg gcctggagcg attggacaat   660
gtggccagcc ttaatcagct taatctctgg actatggatg ctttggaaaa aaatgccatt   720
gtccatgttt gtctaaaaga aatggaacat atggaaactt gtaaagagtc tattcgaatt   780
ttcctaaaag attgtggttt tcaaaatatt accattgaaa ttgatgctga cctagaaact   840
caccaaaccc ataagcgaaa ggtgtgtgac ttggaacgga gttatgagca tcaacat      897

<210>   3854
<211>   299
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cation efflux system protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903714 (e-170)

<400>   3854
Met Arg Asn Met Lys Ala Lys Tyr Ala Val Trp Val Ala Phe Phe Leu 
1               5                   10                  15      

Asn Leu Thr Tyr Ala Ile Val Glu Phe Ile Ala Gly Gly Val Phe Gly 
            20                  25                  30          

Ser Ser Ala Val Leu Ala Asp Ser Val His Asp Leu Gly Asp Ala Ile 
        35                  40                  45              

Ala Ile Gly Ile Ser Ala Phe Leu Glu Thr Ile Ser Asn Arg Glu Glu 
    50                  55                  60                  

Asp Asn Gln Tyr Thr Leu Gly Tyr Lys Arg Phe Ser Leu Leu Gly Ala 
65                  70                  75                  80  

Leu Val Thr Ala Val Ile Leu Val Thr Gly Ser Val Leu Val Ile Leu 
                85                  90                  95      

Glu Asn Val Thr Lys Ile Leu His Pro Gln Pro Val Asn Asp Glu Gly 
            100                 105                 110         

Ile Leu Trp Leu Gly Ile Ile Ala Ile Thr Ile Asn Leu Leu Ala Ser 
        115                 120                 125             

Leu Val Val Gly Lys Gly Lys Thr Lys Asn Glu Ser Ile Leu Ser Leu 
    130                 135                 140                 

His Phe Leu Glu Asp Thr Leu Gly Trp Val Ala Val Ile Leu Met Ala 
145                 150                 155                 160 

Ile Val Leu Arg Phe Thr Asp Trp Tyr Ile Leu Asp Pro Leu Leu Ser 
                165                 170                 175     

Leu Val Ile Ser Phe Phe Ile Leu Ser Lys Ala Leu Pro Arg Phe Trp 
            180                 185                 190         

Ser Thr Leu Lys Ile Phe Leu Asp Ala Val Pro Glu Gly Leu Asp Ile 
        195                 200                 205             

Lys Gln Val Lys Ser Gly Leu Glu Arg Leu Asp Asn Val Ala Ser Leu 
    210                 215                 220                 

Asn Gln Leu Asn Leu Trp Thr Met Asp Ala Leu Glu Lys Asn Ala Ile 
225                 230                 235                 240 

Val His Val Cys Leu Lys Glu Met Glu His Met Glu Thr Cys Lys Glu 
                245                 250                 255     

Ser Ile Arg Ile Phe Leu Lys Asp Cys Gly Phe Gln Asn Ile Thr Ile 
            260                 265                 270         

Glu Ile Asp Ala Asp Leu Glu Thr His Gln Thr His Lys Arg Lys Val 
        275                 280                 285             

Cys Asp Leu Glu Arg Ser Tyr Glu His Gln His 
    290                 295                 

<210>   3855
<211>   534
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3855
atgactaaca ttgaccgccg tatcagcaaa accaaaaaag ccatctatca agcttttata   60
caacttttga atgctaaggg ctacgaggcc actactgttc aggatatcat tgatctcgca   120
gatgtgggac gatccacctt ttactgtcac tatgagagta aggagcttct tctggaccag   180
ctctgccgct acctcttcca tcatcttttt gaaagagagc aagccatttc aaccgaggac   240
tacctcgccc acctctttct ccattttcat aaaaaccaag accatatcac cagtctgcta   300
ttttccaaaa atgactactt cctccgtcaa ctccataaag agctagaaca ccatgtctat   360
tccgtgctag ctgataattt aaaagaagcc caccctaatc tgcctacttc ttacctccaa   420
cacttggtca tgtccaactt tatcgagaca ttgacctggt ggctcaaaaa aggtcaagat   480
ttcacagacc aggaagttgt ccaattttat ctagaccttc tcattcctaa aaat         534

<210>   3856
<211>   178
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, TetR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903715 (e-103)

<400>   3856
Met Thr Asn Ile Asp Arg Arg Ile Ser Lys Thr Lys Lys Ala Ile Tyr 
1               5                   10                  15      

Gln Ala Phe Ile Gln Leu Leu Asn Ala Lys Gly Tyr Glu Ala Thr Thr 
            20                  25                  30          

Val Gln Asp Ile Ile Asp Leu Ala Asp Val Gly Arg Ser Thr Phe Tyr 
        35                  40                  45              

Cys His Tyr Glu Ser Lys Glu Leu Leu Leu Asp Gln Leu Cys Arg Tyr 
    50                  55                  60                  

Leu Phe His His Leu Phe Glu Arg Glu Gln Ala Ile Ser Thr Glu Asp 
65                  70                  75                  80  

Tyr Leu Ala His Leu Phe Leu His Phe His Lys Asn Gln Asp His Ile 
                85                  90                  95      

Thr Ser Leu Leu Phe Ser Lys Asn Asp Tyr Phe Leu Arg Gln Leu His 
            100                 105                 110         

Lys Glu Leu Glu His His Val Tyr Ser Val Leu Ala Asp Asn Leu Lys 
        115                 120                 125             

Glu Ala His Pro Asn Leu Pro Thr Ser Tyr Leu Gln His Leu Val Met 
    130                 135                 140                 

Ser Asn Phe Ile Glu Thr Leu Thr Trp Trp Leu Lys Lys Gly Gln Asp 
145                 150                 155                 160 

Phe Thr Asp Gln Glu Val Val Gln Phe Tyr Leu Asp Leu Leu Ile Pro 
                165                 170                 175     

Lys Asn 
        

<210>   3857
<211>   807
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3857
atgatgcata cttatttgca aaagaaaatt gaaaatatca aaacaaccct aggtgaaatg   60
tcaggtggtt accgtcgtat ggttgcggct atggctgatt taggattttc aggaactatg   120
aaggctatct gggatgacct ctttgcccat cgtagttttg cccagtggat ttatttgctg   180
gttttaggaa gttttcctct ctggctggag ttggtttacg aacatcgtat tgttgactgg   240
attgggatga tttgtagctt gacagggatt atctgtgtaa tctttgtatc ggaaggtcga   300
gcaagtaatt atctttttgg cttgattaac tctgttattt accttatttt ggccctacag   360
aaaggctttt atggtgaggt gctgacgaca ctttacttca cagtcatgca gccaattgga   420
cttctagttt ggatttatca ggcacagttt aagaaggaaa agcaggagtt tgtcgcgcgt   480
aaactggacg gcaagggctg gacaaagtat ctttccatta gtgtgctttg gtggttggcc   540
tttggcttca tttatcagtc tattggtgcc aatcgtccct atcgtgattc aatcacagat   600
gcaaccaatg gggtagggca aatcctcatg acagctgttt accgtgaaca gtggatattc   660
tgggcggcta ccaatgtctt ttcaatctat ctctggtggg gagaaagcct gcaaattcaa   720
gggaaatatc taatttatct cattaacagt ctagttggtt ggtatcaatg gagcaaggca   780
gctaagcaga atactgattt acttaac                                       807

<210>   3858
<211>   269
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903716 (e-160)

<400>   3858
Met Met His Thr Tyr Leu Gln Lys Lys Ile Glu Asn Ile Lys Thr Thr 
1               5                   10                  15      

Leu Gly Glu Met Ser Gly Gly Tyr Arg Arg Met Val Ala Ala Met Ala 
            20                  25                  30          

Asp Leu Gly Phe Ser Gly Thr Met Lys Ala Ile Trp Asp Asp Leu Phe 
        35                  40                  45              

Ala His Arg Ser Phe Ala Gln Trp Ile Tyr Leu Leu Val Leu Gly Ser 
    50                  55                  60                  

Phe Pro Leu Trp Leu Glu Leu Val Tyr Glu His Arg Ile Val Asp Trp 
65                  70                  75                  80  

Ile Gly Met Ile Cys Ser Leu Thr Gly Ile Ile Cys Val Ile Phe Val 
                85                  90                  95      

Ser Glu Gly Arg Ala Ser Asn Tyr Leu Phe Gly Leu Ile Asn Ser Val 
            100                 105                 110         

Ile Tyr Leu Ile Leu Ala Leu Gln Lys Gly Phe Tyr Gly Glu Val Leu 
        115                 120                 125             

Thr Thr Leu Tyr Phe Thr Val Met Gln Pro Ile Gly Leu Leu Val Trp 
    130                 135                 140                 

Ile Tyr Gln Ala Gln Phe Lys Lys Glu Lys Gln Glu Phe Val Ala Arg 
145                 150                 155                 160 

Lys Leu Asp Gly Lys Gly Trp Thr Lys Tyr Leu Ser Ile Ser Val Leu 
                165                 170                 175     

Trp Trp Leu Ala Phe Gly Phe Ile Tyr Gln Ser Ile Gly Ala Asn Arg 
            180                 185                 190         

Pro Tyr Arg Asp Ser Ile Thr Asp Ala Thr Asn Gly Val Gly Gln Ile 
        195                 200                 205             

Leu Met Thr Ala Val Tyr Arg Glu Gln Trp Ile Phe Trp Ala Ala Thr 
    210                 215                 220                 

Asn Val Phe Ser Ile Tyr Leu Trp Trp Gly Glu Ser Leu Gln Ile Gln 
225                 230                 235                 240 

Gly Lys Tyr Leu Ile Tyr Leu Ile Asn Ser Leu Val Gly Trp Tyr Gln 
                245                 250                 255     

Trp Ser Lys Ala Ala Lys Gln Asn Thr Asp Leu Leu Asn 
            260                 265                 

<210>   3859
<211>   1518
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3859
atgactaatt taattgcaac ttttcaggat cgttttagtg attggttgac agctctatct   60
caacatttgc agttgtcgct tttgaccttg ttactagcta ttttgcttgc gattcccttg   120
gctgtttttc ttcgctatca tgagaagctg gccgactggg tcttgcagat tgcaggtatt   180
ttccagacca tcccgtctct ggccttgttg gggctcttta tccctttgat gggaattggg   240
accttgccgg ctttgacagc tctagtgatt tatgcgattt tccctatttt gcaaaatact   300
atcactgggc tgaagggaat tgatccgaac ctgcaagagg ctgggattgc ctttgggatg   360
accagatggg aacgtctcaa gaaatttgaa attccactcg ccatgcctgt tatcatgtct   420
gggattcgga cggcagctgt tttgattatc ggtacggcaa ccttggcggc cttgattggt   480
gcagggggac taggttcctt tattcttttg ggaattgacc gtaataatgc cagtttgatt   540
ttgattgggg cactttcttc tgcagtgcta gccattgcct ttaacttcct actaaaagtg   600
atggaaaaag caaaattacg gacgattttc tcaggttttg ccttggtggc tttattactg   660
ggtctgtctt atagtccagc tcttttggtt caaaaagaga aggaaaactt ggttattgct   720
gggaaaatag gtccagaacc agaaattttg gccaatatgt ataagttgct gattgaagaa   780
aataccagca tgactgcgac tgttaaaccg aattttggga agacaagctt cctttatgaa   840
gctctgaaaa aaggcgatat tgacatctat cctgaattta ctggtacggt gactgaaagt   900
ttgcttcaac catcacccaa ggtgagtcat gaaccagaac aggtttatca ggtggcgcgt   960
gatggcattg ctaagcagga tcatctagcc tatctcaaac ccatgtctta tcaaaacacc   1020
tatgctgtag ctgttccgaa aaagattgct caagaatatg gcttgaagac catttcagac   1080
ttgaaaaaag tggaagggca gttgaaggca ggttttacac tcgagtttaa cgaccgtgaa   1140
gatggaaata agggcttgca atcaatgtat ggtctcaatc tcaatgtagc gaccattgag   1200
ccagcccttc gctatcaggc tattcagtca ggggatattc aaatcacgga tgcctattcg   1260
actgatgcgg aattggagcg ttatgattta caggtcttgg aagatgacaa gcaactcttc   1320
ccaccttatc aaggggctcc actcatgaaa gaagctcttc tcaagaaaca cccagagttg   1380
gaaagagttc ttaatacatt ggctggtaag attacagaaa gccagatgag ccagctcaac   1440
taccaagtcg gtgttgaagg caagtcagca aagcaagtag ccaaggagtt tctccaagaa   1500
caaggtttgt tgaagaaa                                                 1518

<210>   3860
<211>   506
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline transporter (proWX)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903719 (0.E+01)

<400>   3860
Met Thr Asn Leu Ile Ala Thr Phe Gln Asp Arg Phe Ser Asp Trp Leu 
1               5                   10                  15      

Thr Ala Leu Ser Gln His Leu Gln Leu Ser Leu Leu Thr Leu Leu Leu 
            20                  25                  30          

Ala Ile Leu Leu Ala Ile Pro Leu Ala Val Phe Leu Arg Tyr His Glu 
        35                  40                  45              

Lys Leu Ala Asp Trp Val Leu Gln Ile Ala Gly Ile Phe Gln Thr Ile 
    50                  55                  60                  

Pro Ser Leu Ala Leu Leu Gly Leu Phe Ile Pro Leu Met Gly Ile Gly 
65                  70                  75                  80  

Thr Leu Pro Ala Leu Thr Ala Leu Val Ile Tyr Ala Ile Phe Pro Ile 
                85                  90                  95      

Leu Gln Asn Thr Ile Thr Gly Leu Lys Gly Ile Asp Pro Asn Leu Gln 
            100                 105                 110         

Glu Ala Gly Ile Ala Phe Gly Met Thr Arg Trp Glu Arg Leu Lys Lys 
        115                 120                 125             

Phe Glu Ile Pro Leu Ala Met Pro Val Ile Met Ser Gly Ile Arg Thr 
    130                 135                 140                 

Ala Ala Val Leu Ile Ile Gly Thr Ala Thr Leu Ala Ala Leu Ile Gly 
145                 150                 155                 160 

Ala Gly Gly Leu Gly Ser Phe Ile Leu Leu Gly Ile Asp Arg Asn Asn 
                165                 170                 175     

Ala Ser Leu Ile Leu Ile Gly Ala Leu Ser Ser Ala Val Leu Ala Ile 
            180                 185                 190         

Ala Phe Asn Phe Leu Leu Lys Val Met Glu Lys Ala Lys Leu Arg Thr 
        195                 200                 205             

Ile Phe Ser Gly Phe Ala Leu Val Ala Leu Leu Leu Gly Leu Ser Tyr 
    210                 215                 220                 

Ser Pro Ala Leu Leu Val Gln Lys Glu Lys Glu Asn Leu Val Ile Ala 
225                 230                 235                 240 

Gly Lys Ile Gly Pro Glu Pro Glu Ile Leu Ala Asn Met Tyr Lys Leu 
                245                 250                 255     

Leu Ile Glu Glu Asn Thr Ser Met Thr Ala Thr Val Lys Pro Asn Phe 
            260                 265                 270         

Gly Lys Thr Ser Phe Leu Tyr Glu Ala Leu Lys Lys Gly Asp Ile Asp 
        275                 280                 285             

Ile Tyr Pro Glu Phe Thr Gly Thr Val Thr Glu Ser Leu Leu Gln Pro 
    290                 295                 300                 

Ser Pro Lys Val Ser His Glu Pro Glu Gln Val Tyr Gln Val Ala Arg 
305                 310                 315                 320 

Asp Gly Ile Ala Lys Gln Asp His Leu Ala Tyr Leu Lys Pro Met Ser 
                325                 330                 335     

Tyr Gln Asn Thr Tyr Ala Val Ala Val Pro Lys Lys Ile Ala Gln Glu 
            340                 345                 350         

Tyr Gly Leu Lys Thr Ile Ser Asp Leu Lys Lys Val Glu Gly Gln Leu 
        355                 360                 365             

Lys Ala Gly Phe Thr Leu Glu Phe Asn Asp Arg Glu Asp Gly Asn Lys 
    370                 375                 380                 

Gly Leu Gln Ser Met Tyr Gly Leu Asn Leu Asn Val Ala Thr Ile Glu 
385                 390                 395                 400 

Pro Ala Leu Arg Tyr Gln Ala Ile Gln Ser Gly Asp Ile Gln Ile Thr 
                405                 410                 415     

Asp Ala Tyr Ser Thr Asp Ala Glu Leu Glu Arg Tyr Asp Leu Gln Val 
            420                 425                 430         

Leu Glu Asp Asp Lys Gln Leu Phe Pro Pro Tyr Gln Gly Ala Pro Leu 
        435                 440                 445             

Met Lys Glu Ala Leu Leu Lys Lys His Pro Glu Leu Glu Arg Val Leu 
    450                 455                 460                 

Asn Thr Leu Ala Gly Lys Ile Thr Glu Ser Gln Met Ser Gln Leu Asn 
465                 470                 475                 480 

Tyr Gln Val Gly Val Glu Gly Lys Ser Ala Lys Gln Val Ala Lys Glu 
                485                 490                 495     

Phe Leu Gln Glu Gln Gly Leu Leu Lys Lys 
            500                 505     

<210>   3861
<211>   726
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3861
atgattgaat acaaaaatgt agcactgcgc tacacagaaa aggatgtctt gagagatgtc   60
aacttacaga ttgaggatgg ggaatttatg gttttagtag ggccttctgg gtcaggtaag   120
acgaccatgc tcaagatgat taaccgtctt ttggaaccaa ctgatggaaa tatttatatg   180
gatgggaagc gcatcaaaga ctatgatgag cgtgaacttc gtctttctac tggttatgtt   240
ttacaggcta ttgctctttt tccaaatcta acagttgcgg aaaatattgc tctcattcct   300
gaaatgaagg ggtggagcaa ggaagaaatt acgaagaaaa cagaagagct tttggctaag   360
gttggtttac cagtagccga gtatgggcat cgcttaccta gtgaattatc tggtggagaa   420
cagcaacggg tcggtattgt ccgagctatg attggtcagc ccaagatttt cctcatggat   480
gaaccctttt cggccttgga tgctatttcg agaaaacagt tgcaggttct gacaaaagaa   540
ttgcataaag agtttgggat gacaacgatt tttgtaaccc atgatacgga tgaagccttg   600
aagttggcgg accgtattgc tgtcttgcag gatggagaaa ttcgccaggt agcgaatccc   660
gagacaattt taaaagcgcc tgcaacagac tttgtagcag acttgtttgg aggtagtgtt   720
catgac                                                              726

<210>   3862
<211>   242
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline transporter (proV)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903720 (e-132)

<400>   3862
Met Ile Glu Tyr Lys Asn Val Ala Leu Arg Tyr Thr Glu Lys Asp Val 
1               5                   10                  15      

Leu Arg Asp Val Asn Leu Gln Ile Glu Asp Gly Glu Phe Met Val Leu 
            20                  25                  30          

Val Gly Pro Ser Gly Ser Gly Lys Thr Thr Met Leu Lys Met Ile Asn 
        35                  40                  45              

Arg Leu Leu Glu Pro Thr Asp Gly Asn Ile Tyr Met Asp Gly Lys Arg 
    50                  55                  60                  

Ile Lys Asp Tyr Asp Glu Arg Glu Leu Arg Leu Ser Thr Gly Tyr Val 
65                  70                  75                  80  

Leu Gln Ala Ile Ala Leu Phe Pro Asn Leu Thr Val Ala Glu Asn Ile 
                85                  90                  95      

Ala Leu Ile Pro Glu Met Lys Gly Trp Ser Lys Glu Glu Ile Thr Lys 
            100                 105                 110         

Lys Thr Glu Glu Leu Leu Ala Lys Val Gly Leu Pro Val Ala Glu Tyr 
        115                 120                 125             

Gly His Arg Leu Pro Ser Glu Leu Ser Gly Gly Glu Gln Gln Arg Val 
    130                 135                 140                 

Gly Ile Val Arg Ala Met Ile Gly Gln Pro Lys Ile Phe Leu Met Asp 
145                 150                 155                 160 

Glu Pro Phe Ser Ala Leu Asp Ala Ile Ser Arg Lys Gln Leu Gln Val 
                165                 170                 175     

Leu Thr Lys Glu Leu His Lys Glu Phe Gly Met Thr Thr Ile Phe Val 
            180                 185                 190         

Thr His Asp Thr Asp Glu Ala Leu Lys Leu Ala Asp Arg Ile Ala Val 
        195                 200                 205             

Leu Gln Asp Gly Glu Ile Arg Gln Val Ala Asn Pro Glu Thr Ile Leu 
    210                 215                 220                 

Lys Ala Pro Ala Thr Asp Phe Val Ala Asp Leu Phe Gly Gly Ser Val 
225                 230                 235                 240 

His Asp 
        

<210>   3863
<211>   762
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3863
atgtcacaac aagtgaaaaa tgctcacaac ctatacatcc atgccattca agacggacga   60
gttgctgagg ctcaagccca gtctgtaggg gatacctata tccaacattc gacaggtgtt   120
cctgacggga aagaaggatt tgcagccttc tttgcagatt tctttgagcg tcatccagag   180
cgtcagatta agattgtccg caccattgag gatggcaatc tggtctttgt tcatgttcat   240
caatatctga atggtggaga agctcaatgg gtgacgacgg atactttccg tgaggatgag   300
aatggttgta ttgttgagca ttgggatgtc attgactact atcgaacacc tgaaaatgac   360
caactagatc aaatttttgg agattttgaa atcaaggatt tggataagaa agcagaaaat   420
aaaaagctgg ttcgccgttt cttgacagaa attttccaaa atggggagct agagcagtgg   480
agtgattatg tggcagacga tttgattcag cataatcatg atattggaca aggaagtgct   540
gcttataaaa actatgtggc tgaatatagt gtcacttttg actttgtttt ccaactctta   600
ggacaaggaa actatgtggt tagctatggt cagactcaga ttgatggcgt tgcttatgcc   660
cagtacgata tcttccgttt agagaacggg aaaattgtgg agcattggga taataaggaa   720
gttatgccta aggtagaaga cttgaccaat cgagggaagt tt                      762

<210>   3864
<211>   254
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903721 (e-151)

<400>   3864
Met Ser Gln Gln Val Lys Asn Ala His Asn Leu Tyr Ile His Ala Ile 
1               5                   10                  15      

Gln Asp Gly Arg Val Ala Glu Ala Gln Ala Gln Ser Val Gly Asp Thr 
            20                  25                  30          

Tyr Ile Gln His Ser Thr Gly Val Pro Asp Gly Lys Glu Gly Phe Ala 
        35                  40                  45              

Ala Phe Phe Ala Asp Phe Phe Glu Arg His Pro Glu Arg Gln Ile Lys 
    50                  55                  60                  

Ile Val Arg Thr Ile Glu Asp Gly Asn Leu Val Phe Val His Val His 
65                  70                  75                  80  

Gln Tyr Leu Asn Gly Gly Glu Ala Gln Trp Val Thr Thr Asp Thr Phe 
                85                  90                  95      

Arg Glu Asp Glu Asn Gly Cys Ile Val Glu His Trp Asp Val Ile Asp 
            100                 105                 110         

Tyr Tyr Arg Thr Pro Glu Asn Asp Gln Leu Asp Gln Ile Phe Gly Asp 
        115                 120                 125             

Phe Glu Ile Lys Asp Leu Asp Lys Lys Ala Glu Asn Lys Lys Leu Val 
    130                 135                 140                 

Arg Arg Phe Leu Thr Glu Ile Phe Gln Asn Gly Glu Leu Glu Gln Trp 
145                 150                 155                 160 

Ser Asp Tyr Val Ala Asp Asp Leu Ile Gln His Asn His Asp Ile Gly 
                165                 170                 175     

Gln Gly Ser Ala Ala Tyr Lys Asn Tyr Val Ala Glu Tyr Ser Val Thr 
            180                 185                 190         

Phe Asp Phe Val Phe Gln Leu Leu Gly Gln Gly Asn Tyr Val Val Ser 
        195                 200                 205             

Tyr Gly Gln Thr Gln Ile Asp Gly Val Ala Tyr Ala Gln Tyr Asp Ile 
    210                 215                 220                 

Phe Arg Leu Glu Asn Gly Lys Ile Val Glu His Trp Asp Asn Lys Glu 
225                 230                 235                 240 

Val Met Pro Lys Val Glu Asp Leu Thr Asn Arg Gly Lys Phe 
                245                 250                 

<210>   3865
<211>   441
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3865
atgaaagatg gtcatttgct agcccatcat attcgtttgt tgaatgggcg gatttttcaa   60
aagttactga gtcaagatcc tgaggctctt tataggggtg aacagggcaa gattttagcg   120
gttttatgga atagtgaaac tggctgcgca actgcgacag atatcgcgct tgcgactgga   180
cttgcgaata atacgctgac gactatgata aaaaagctag aggaacaaaa gcttgtaatt   240
gttagtccgt gtggaaaaga caagcgtaag aagtatttag ttttaacgga gttaggcaag   300
tcccagaaag aagtggggca tcgtgtcagt cagaaattgg atactatctt ttacaaagga   360
ttttcagagg aagaaattca ccaatttgaa ggttttcaag aaagaatttt ggcgaatctg   420
aaagagaagg gaaatgaggt t                                             441

<210>   3866
<211>   147
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, MarR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903722 (2.E-81)

<400>   3866
Met Lys Asp Gly His Leu Leu Ala His His Ile Arg Leu Leu Asn Gly 
1               5                   10                  15      

Arg Ile Phe Gln Lys Leu Leu Ser Gln Asp Pro Glu Ala Leu Tyr Arg 
            20                  25                  30          

Gly Glu Gln Gly Lys Ile Leu Ala Val Leu Trp Asn Ser Glu Thr Gly 
        35                  40                  45              

Cys Ala Thr Ala Thr Asp Ile Ala Leu Ala Thr Gly Leu Ala Asn Asn 
    50                  55                  60                  

Thr Leu Thr Thr Met Ile Lys Lys Leu Glu Glu Gln Lys Leu Val Ile 
65                  70                  75                  80  

Val Ser Pro Cys Gly Lys Asp Lys Arg Lys Lys Tyr Leu Val Leu Thr 
                85                  90                  95      

Glu Leu Gly Lys Ser Gln Lys Glu Val Gly His Arg Val Ser Gln Lys 
            100                 105                 110         

Leu Asp Thr Ile Phe Tyr Lys Gly Phe Ser Glu Glu Glu Ile His Gln 
        115                 120                 125             

Phe Glu Gly Phe Gln Glu Arg Ile Leu Ala Asn Leu Lys Glu Lys Gly 
    130                 135                 140                 

Asn Glu Val 
145         

<210>   3867
<211>   294
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3867
atggtagaac caaacctaga aagccttata aaagatcttt acaatcatgc tcgacatgat   60
ttgagtgaag atttagttgc tgctctccta gagactacta aaaaactgcc tactacaaat   120
gagcaattgc aggcagttcg tctctcaggc ctggtcaatc gtgaattgct cctaaatccc   180
aaacatccag cacctgagtt gctcaacttg gctcgctttg tcaaaagaga agaagccaag   240
tacagaggaa ctgcgacttc tgcgcttatg tatgaggaac tctttaaaat gctt         294

<210>   3868
<211>   98
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903723 (3.E-50)

<400>   3868
Met Val Glu Pro Asn Leu Glu Ser Leu Ile Lys Asp Leu Tyr Asn His 
1               5                   10                  15      

Ala Arg His Asp Leu Ser Glu Asp Leu Val Ala Ala Leu Leu Glu Thr 
            20                  25                  30          

Thr Lys Lys Leu Pro Thr Thr Asn Glu Gln Leu Gln Ala Val Arg Leu 
        35                  40                  45              

Ser Gly Leu Val Asn Arg Glu Leu Leu Leu Asn Pro Lys His Pro Ala 
    50                  55                  60                  

Pro Glu Leu Leu Asn Leu Ala Arg Phe Val Lys Arg Glu Glu Ala Lys 
65                  70                  75                  80  

Tyr Arg Gly Thr Ala Thr Ser Ala Leu Met Tyr Glu Glu Leu Phe Lys 
                85                  90                  95      

Met Leu 
        

<210>   3869
<211>   1062
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3869
atgacaacat tattttcaaa aattaaagaa gtaacagaac ttgctgcagt ctcaggtcat   60
gaagcgcctg tccgtgctta tcttcgtgaa aagttgacac cgcatgtgga tgaagtggtg   120
acagatggct tgggtggtat ttttggtatc aaacattcag aagctgtgga tgcaccgcgc   180
gtcttggtcg cttctcatat ggacgaagtt ggttttatgg tcagcgaaat caagccagat   240
ggtaccttcc gtgtcgtaga aatcggtggc tggaacccca tggtggttag cagccaacgt   300
ttcaaactct tgactcgtga tggtcatgaa attcctgtga tttcaggttc tgttcctccg   360
catttgactc gtggaaaggg gggaccaacc atgccagcca ttgccgatat cgtttttgat   420
ggtggttttg cggacaaggc tgaggcagaa agttttggca tccgtcctgg tgataccatt   480
gtaccagata gttctgcaat tttgacagcc aatgaaaaaa atatcatctc aaaagcttgg   540
gataaccgct acggtgtcct catggtaagc gagctagctg aagctttatc gggtcaaaaa   600
ctcggcaatg aactctatct gggttctaac gtccaagaag aagttggtct gcgtggcgct   660
catacctcta caaccaagtt tgacccagaa gtcttcctcg cagttgattg ctcaccagca   720
ggtgatgtct acggtggtca aggcaagatt ggagatggaa ccttgattcg tttctatgat   780
ccaggtcact tgcttctccc agggatgaag gatttccttt tgacaacggc tgaagaagct   840
ggtatcaagt accaatacta ctgtggtaaa ggcggaacag atgcaggtgc agctcatctg   900
aaaaatggtg gtgtcccatc aacaactatc ggtgtctgcg ctcgttatat ccattctcac   960
caaaccctct atgcaatgga tgacttccta gaagcgcaag ctttcttaca agccttggtg   1020
aagaaattgg atcgttcaac ggttgatttg attaaacatt at                      1062

<210>   3870
<211>   354
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamyl-aminopeptidase (pepA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903724 (0.E+01)

<400>   3870
Met Thr Thr Leu Phe Ser Lys Ile Lys Glu Val Thr Glu Leu Ala Ala 
1               5                   10                  15      

Val Ser Gly His Glu Ala Pro Val Arg Ala Tyr Leu Arg Glu Lys Leu 
            20                  25                  30          

Thr Pro His Val Asp Glu Val Val Thr Asp Gly Leu Gly Gly Ile Phe 
        35                  40                  45              

Gly Ile Lys His Ser Glu Ala Val Asp Ala Pro Arg Val Leu Val Ala 
    50                  55                  60                  

Ser His Met Asp Glu Val Gly Phe Met Val Ser Glu Ile Lys Pro Asp 
65                  70                  75                  80  

Gly Thr Phe Arg Val Val Glu Ile Gly Gly Trp Asn Pro Met Val Val 
                85                  90                  95      

Ser Ser Gln Arg Phe Lys Leu Leu Thr Arg Asp Gly His Glu Ile Pro 
            100                 105                 110         

Val Ile Ser Gly Ser Val Pro Pro His Leu Thr Arg Gly Lys Gly Gly 
        115                 120                 125             

Pro Thr Met Pro Ala Ile Ala Asp Ile Val Phe Asp Gly Gly Phe Ala 
    130                 135                 140                 

Asp Lys Ala Glu Ala Glu Ser Phe Gly Ile Arg Pro Gly Asp Thr Ile 
145                 150                 155                 160 

Val Pro Asp Ser Ser Ala Ile Leu Thr Ala Asn Glu Lys Asn Ile Ile 
                165                 170                 175     

Ser Lys Ala Trp Asp Asn Arg Tyr Gly Val Leu Met Val Ser Glu Leu 
            180                 185                 190         

Ala Glu Ala Leu Ser Gly Gln Lys Leu Gly Asn Glu Leu Tyr Leu Gly 
        195                 200                 205             

Ser Asn Val Gln Glu Glu Val Gly Leu Arg Gly Ala His Thr Ser Thr 
    210                 215                 220                 

Thr Lys Phe Asp Pro Glu Val Phe Leu Ala Val Asp Cys Ser Pro Ala 
225                 230                 235                 240 

Gly Asp Val Tyr Gly Gly Gln Gly Lys Ile Gly Asp Gly Thr Leu Ile 
                245                 250                 255     

Arg Phe Tyr Asp Pro Gly His Leu Leu Leu Pro Gly Met Lys Asp Phe 
            260                 265                 270         

Leu Leu Thr Thr Ala Glu Glu Ala Gly Ile Lys Tyr Gln Tyr Tyr Cys 
        275                 280                 285             

Gly Lys Gly Gly Thr Asp Ala Gly Ala Ala His Leu Lys Asn Gly Gly 
    290                 295                 300                 

Val Pro Ser Thr Thr Ile Gly Val Cys Ala Arg Tyr Ile His Ser His 
305                 310                 315                 320 

Gln Thr Leu Tyr Ala Met Asp Asp Phe Leu Glu Ala Gln Ala Phe Leu 
                325                 330                 335     

Gln Ala Leu Val Lys Lys Leu Asp Arg Ser Thr Val Asp Leu Ile Lys 
            340                 345                 350         

His Tyr 
        

<210>   3871
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3871
ttgcatgtag tgcaaaatct agtaaacatt ccaaaattaa ctcgaatatt tatttccaaa   60
caaaaaaaca atacaccatc aaagttgttt ggatttttca tgaaatttac agaaaatagt   120

<210>   3872
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3872
Met His Val Val Gln Asn Leu Val Asn Ile Pro Lys Leu Thr Arg Ile 
1               5                   10                  15      

Phe Ile Ser Lys Gln Lys Asn Asn Thr Pro Ser Lys Leu Phe Gly Phe 
            20                  25                  30          

Phe Met Lys Phe Thr Glu Asn Ser 
        35                  40  

<210>   3873
<211>   699
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3873
atgaccaaaa caattcttgt tacaggtggg actagctaca ttggctccca taccgttaaa   60
gctcttttaa atgctggcta tcaggtgcat gtcctcgata atctctccac aggaaatcga   120
gcggctgtgg atagtcgtgc tagctttaaa gaactggatg tttatgatgc tagcgcctta   180
aaggcttact tagaagaaaa tcagattgat gctgtcctcc attgtgcagg tgaaattgtt   240
gtgagcgaaa gtattgaaaa tccaagtaaa tacttcactg ccaacgttgc tggtatgaac   300
caagttctca aagtcttatc tgaagttggc attcaaaaaa tcatgttctc ttcgactgct   360
tctctctatg gaaataactg tattgacaag ccggtgactg aagataccct gctcgaccct   420
gtcaaccctt atgcagagac aaaactgatg ggcgaacgaa tgatttactg gatggccaat   480
cgctacgact ggaaatatgt tattttccgt tactttaatg ttgctggggc tgaaatggat   540
gcttcaaacg gtctgcgtgt gaaaaatcca actcacatca ttccaaatat caacaagacc   600
gcattgggac aaaatgatag cttaaaaata tttggagatg actacgatac acgtgacggt   660
tcatgtattc gagattacat ttatgtcttg gaccttgca                          699

<210>   3874
<211>   233
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   NAD-dependent epimerase/dehydratase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903725 (e-132)

<400>   3874
Met Thr Lys Thr Ile Leu Val Thr Gly Gly Thr Ser Tyr Ile Gly Ser 
1               5                   10                  15      

His Thr Val Lys Ala Leu Leu Asn Ala Gly Tyr Gln Val His Val Leu 
            20                  25                  30          

Asp Asn Leu Ser Thr Gly Asn Arg Ala Ala Val Asp Ser Arg Ala Ser 
        35                  40                  45              

Phe Lys Glu Leu Asp Val Tyr Asp Ala Ser Ala Leu Lys Ala Tyr Leu 
    50                  55                  60                  

Glu Glu Asn Gln Ile Asp Ala Val Leu His Cys Ala Gly Glu Ile Val 
65                  70                  75                  80  

Val Ser Glu Ser Ile Glu Asn Pro Ser Lys Tyr Phe Thr Ala Asn Val 
                85                  90                  95      

Ala Gly Met Asn Gln Val Leu Lys Val Leu Ser Glu Val Gly Ile Gln 
            100                 105                 110         

Lys Ile Met Phe Ser Ser Thr Ala Ser Leu Tyr Gly Asn Asn Cys Ile 
        115                 120                 125             

Asp Lys Pro Val Thr Glu Asp Thr Leu Leu Asp Pro Val Asn Pro Tyr 
    130                 135                 140                 

Ala Glu Thr Lys Leu Met Gly Glu Arg Met Ile Tyr Trp Met Ala Asn 
145                 150                 155                 160 

Arg Tyr Asp Trp Lys Tyr Val Ile Phe Arg Tyr Phe Asn Val Ala Gly 
                165                 170                 175     

Ala Glu Met Asp Ala Ser Asn Gly Leu Arg Val Lys Asn Pro Thr His 
            180                 185                 190         

Ile Ile Pro Asn Ile Asn Lys Thr Ala Leu Gly Gln Asn Asp Ser Leu 
        195                 200                 205             

Lys Ile Phe Gly Asp Asp Tyr Asp Thr Arg Asp Gly Ser Cys Ile Arg 
    210                 215                 220                 

Asp Tyr Ile Tyr Val Leu Asp Leu Ala 
225                 230             

<210>   3875
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3875
atgaactacc tatttcaaga agacagttct tctcaaatct ttaacttagg aactaaaaaa   60
ggctatacta tcaaagaaat ctttaaaact gctgaagaat tactaaat                108

<210>   3876
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm

<400>   3876
Met Asn Tyr Leu Phe Gln Glu Asp Ser Ser Ser Gln Ile Phe Asn Leu 
1               5                   10                  15      

Gly Thr Lys Lys Gly Tyr Thr Ile Lys Glu Ile Phe Lys Thr Ala Glu 
            20                  25                  30          

Glu Leu Leu Asn 
        35      

<210>   3877
<211>   972
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3877
atgaaaggac ggggtatgaa actttctcat tatttaattg gcttacttct actcctagtc   60
tttctctcta ttagcattgg gaccagtgat ttttcatggg gaaagctatt tgatttcgac   120
cagcagacct ggctcctctt tcaagagtcc cgtctcccaa gaactatcag tattctcctg   180
actgcctcta gtatgagtat ggcaggcctt ctcatgcaga ctattaccca aaatcagttt   240
gctgcaccga gtacagttgg aacgactgaa gccgccaaac tgggaatggt gctgagcctt   300
tttgtctttc catcggctag tctgacccac aagatgctct tcgcttttgt ttcatccatc   360
gtattcaccc tcttcttcct agcctttatg accattttta ctgtaaagga aaggtggatg   420
ttgcctctga ttgggatcat ctatagcggg attatcggct cagtcacaga agttatcgcc   480
tatcgtttca atctggttca gagtatgact gcctggaccc agggctcctt ctccatgatt   540
cagacccatc agtatgagtg gctcttctta ggcctcatca tcctgataac cgtttggaaa   600
ttatcccaaa ccttcaccat catgaatcta gggaaagaaa ccagcgagag tttggggatt   660
tcctactccc tacttgaaaa actggccctc tttctggtgg cgctaacgac aagcgtcacc   720
atgattaccg tgggtggcct accatttctc ggagttatcg ttcccaatct tgttcgcaag   780
cgctatggag ataatctaag tcaaaccaaa ctcatggtcg cactggttgg tgccaatcta   840
gttctggctt gcgatatcct atcccgagtt ctgattaggc cctatgagtt gtctgtcagt   900
ctcttgctag gaatcatcgg tagtctcgtc tttatcctac ttctctggag agggggacga   960
aaagatgcag ac                                                       972

<210>   3878
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron-compound ABC transporter, permerase protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903726 (e-179)

<400>   3878
Met Lys Gly Arg Gly Met Lys Leu Ser His Tyr Leu Ile Gly Leu Leu 
1               5                   10                  15      

Leu Leu Leu Val Phe Leu Ser Ile Ser Ile Gly Thr Ser Asp Phe Ser 
            20                  25                  30          

Trp Gly Lys Leu Phe Asp Phe Asp Gln Gln Thr Trp Leu Leu Phe Gln 
        35                  40                  45              

Glu Ser Arg Leu Pro Arg Thr Ile Ser Ile Leu Leu Thr Ala Ser Ser 
    50                  55                  60                  

Met Ser Met Ala Gly Leu Leu Met Gln Thr Ile Thr Gln Asn Gln Phe 
65                  70                  75                  80  

Ala Ala Pro Ser Thr Val Gly Thr Thr Glu Ala Ala Lys Leu Gly Met 
                85                  90                  95      

Val Leu Ser Leu Phe Val Phe Pro Ser Ala Ser Leu Thr His Lys Met 
            100                 105                 110         

Leu Phe Ala Phe Val Ser Ser Ile Val Phe Thr Leu Phe Phe Leu Ala 
        115                 120                 125             

Phe Met Thr Ile Phe Thr Val Lys Glu Arg Trp Met Leu Pro Leu Ile 
    130                 135                 140                 

Gly Ile Ile Tyr Ser Gly Ile Ile Gly Ser Val Thr Glu Val Ile Ala 
145                 150                 155                 160 

Tyr Arg Phe Asn Leu Val Gln Ser Met Thr Ala Trp Thr Gln Gly Ser 
                165                 170                 175     

Phe Ser Met Ile Gln Thr His Gln Tyr Glu Trp Leu Phe Leu Gly Leu 
            180                 185                 190         

Ile Ile Leu Ile Thr Val Trp Lys Leu Ser Gln Thr Phe Thr Ile Met 
        195                 200                 205             

Asn Leu Gly Lys Glu Thr Ser Glu Ser Leu Gly Ile Ser Tyr Ser Leu 
    210                 215                 220                 

Leu Glu Lys Leu Ala Leu Phe Leu Val Ala Leu Thr Thr Ser Val Thr 
225                 230                 235                 240 

Met Ile Thr Val Gly Gly Leu Pro Phe Leu Gly Val Ile Val Pro Asn 
                245                 250                 255     

Leu Val Arg Lys Arg Tyr Gly Asp Asn Leu Ser Gln Thr Lys Leu Met 
            260                 265                 270         

Val Ala Leu Val Gly Ala Asn Leu Val Leu Ala Cys Asp Ile Leu Ser 
        275                 280                 285             

Arg Val Leu Ile Arg Pro Tyr Glu Leu Ser Val Ser Leu Leu Leu Gly 
    290                 295                 300                 

Ile Ile Gly Ser Leu Val Phe Ile Leu Leu Leu Trp Arg Gly Gly Arg 
305                 310                 315                 320 

Lys Asp Ala Asp 
                

<210>   3879
<211>   954
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3879
atgcagacta aaagcaaaca taccaagctc ttctggattc tcattattct tgccatcgga   60
gcttgtcttc tctacttttg gcccatcact cacttgtcag cctttgcttg gaagttgcgt   120
tcccaaaaga tcatcgttta tctcttggta gccatcgcga ctgggatttc gaccattagt   180
tttcaaaccc tgacggaaaa tcgcttcctg acgcctagta ttttgggaat tgaatccttc   240
tacgtcctac tacaaaccct actactggtt tttgaaagca agtttcttca acttggcaaa   300
tcccctatct tagaattcct agtcttactt cttgtccagt ccctcttctt tctcgcctta   360
caaggttact tgaagacact gatgaagcaa gacctggtct tcgtcctgct gatctgtcta   420
gcgctcagaa gtctctttcg aaatatcagc accttccttc aagtcctaat ggatccaaac   480
gaatacgata aactgcaaaa tagtcttttt gcctcctttc aacatctcaa cacttccatc   540
ctagccatcg gttctctgat catcctcgct ttgacaatct ttttctttcg aaaagcagtc   600
gttctagatg tcttgcacct gcaaagagaa acggctcaga tattgggact cgatgttgaa   660
aaagaacaga aagagctcct ctggggaatc gtgcttttga cctcaacggc cactgccttg   720
gtaggaccta tggccttctt cggctttata ctggccaacc tcacctacct gattgtcaaa   780
gactatcagc acaagttact ctttatagtg gccattctgg ttggatttat tagcttaacc   840
ttggggcaag ccttgattga acgagtcttt gcactggaaa ttcgtatcag tatgatcatt   900
gagagtgtgg gtggcttctt attctttatc ttactatata ggaggtctcg tcag         954

<210>   3880
<211>   318
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron-compound ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903727 (e-173)

<400>   3880
Met Gln Thr Lys Ser Lys His Thr Lys Leu Phe Trp Ile Leu Ile Ile 
1               5                   10                  15      

Leu Ala Ile Gly Ala Cys Leu Leu Tyr Phe Trp Pro Ile Thr His Leu 
            20                  25                  30          

Ser Ala Phe Ala Trp Lys Leu Arg Ser Gln Lys Ile Ile Val Tyr Leu 
        35                  40                  45              

Leu Val Ala Ile Ala Thr Gly Ile Ser Thr Ile Ser Phe Gln Thr Leu 
    50                  55                  60                  

Thr Glu Asn Arg Phe Leu Thr Pro Ser Ile Leu Gly Ile Glu Ser Phe 
65                  70                  75                  80  

Tyr Val Leu Leu Gln Thr Leu Leu Leu Val Phe Glu Ser Lys Phe Leu 
                85                  90                  95      

Gln Leu Gly Lys Ser Pro Ile Leu Glu Phe Leu Val Leu Leu Leu Val 
            100                 105                 110         

Gln Ser Leu Phe Phe Leu Ala Leu Gln Gly Tyr Leu Lys Thr Leu Met 
        115                 120                 125             

Lys Gln Asp Leu Val Phe Val Leu Leu Ile Cys Leu Ala Leu Arg Ser 
    130                 135                 140                 

Leu Phe Arg Asn Ile Ser Thr Phe Leu Gln Val Leu Met Asp Pro Asn 
145                 150                 155                 160 

Glu Tyr Asp Lys Leu Gln Asn Ser Leu Phe Ala Ser Phe Gln His Leu 
                165                 170                 175     

Asn Thr Ser Ile Leu Ala Ile Gly Ser Leu Ile Ile Leu Ala Leu Thr 
            180                 185                 190         

Ile Phe Phe Phe Arg Lys Ala Val Val Leu Asp Val Leu His Leu Gln 
        195                 200                 205             

Arg Glu Thr Ala Gln Ile Leu Gly Leu Asp Val Glu Lys Glu Gln Lys 
    210                 215                 220                 

Glu Leu Leu Trp Gly Ile Val Leu Leu Thr Ser Thr Ala Thr Ala Leu 
225                 230                 235                 240 

Val Gly Pro Met Ala Phe Phe Gly Phe Ile Leu Ala Asn Leu Thr Tyr 
                245                 250                 255     

Leu Ile Val Lys Asp Tyr Gln His Lys Leu Leu Phe Ile Val Ala Ile 
            260                 265                 270         

Leu Val Gly Phe Ile Ser Leu Thr Leu Gly Gln Ala Leu Ile Glu Arg 
        275                 280                 285             

Val Phe Ala Leu Glu Ile Arg Ile Ser Met Ile Ile Glu Ser Val Gly 
    290                 295                 300                 

Gly Phe Leu Phe Phe Ile Leu Leu Tyr Arg Arg Ser Arg Gln 
305                 310                 315             

<210>   3881
<211>   750
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3881
gtgaaactgg aaaacattga caaatccatt caaaaacagg atattttgca aggcatttcg   60
cttgaagtca gtcctcaaaa actgacagcc tttattggtc caaatggtgc tggaaaatcg   120
actctcctct ccatcatgag caggctaacc aagaaagatc agggagttct cagtatcaaa   180
ggacgtgaaa tcgagagctg gaattcgcaa gaactggccc aagaactaac catcctaaaa   240
cagaaaatca attaccaagc caaattgact gttgaagaac tggtcagttt tggacgtttt   300
ccctacagcc gaggtcgact tagatcagaa gactgggaaa aaatccgaga aactctgaac   360
tatttagaac tgaccaactt aaaagaccgc tacatcaata gcctgtcagg ggggcaactc   420
cagcgcgtct ttatcgctat ggtactggcc caggatacgg actttatctt gctggacgaa   480
ccactcaaca atctcgatat caagcaaagc gtcagcatga tgcagattct tcgacgactg   540
gtggaggaac tcggcaagac cattatcatc gtcctccacg atatcaacat ggccagtcag   600
tatgcagatg aaattgtcgc cttcaaggac ggccaggtct ttagcaaggg aagaaccgat   660
caaatcatgc aggctgacct gctcagtcaa ctttatgaga ttcccatcac gctagctgat   720
atcaatgaca aaaagatctg tatctatagc                                    750

<210>   3882
<211>   250
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron-compound ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903728 (e-137)

<400>   3882
Met Lys Leu Glu Asn Ile Asp Lys Ser Ile Gln Lys Gln Asp Ile Leu 
1               5                   10                  15      

Gln Gly Ile Ser Leu Glu Val Ser Pro Gln Lys Leu Thr Ala Phe Ile 
            20                  25                  30          

Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu Leu Ser Ile Met Ser Arg 
        35                  40                  45              

Leu Thr Lys Lys Asp Gln Gly Val Leu Ser Ile Lys Gly Arg Glu Ile 
    50                  55                  60                  

Glu Ser Trp Asn Ser Gln Glu Leu Ala Gln Glu Leu Thr Ile Leu Lys 
65                  70                  75                  80  

Gln Lys Ile Asn Tyr Gln Ala Lys Leu Thr Val Glu Glu Leu Val Ser 
                85                  90                  95      

Phe Gly Arg Phe Pro Tyr Ser Arg Gly Arg Leu Arg Ser Glu Asp Trp 
            100                 105                 110         

Glu Lys Ile Arg Glu Thr Leu Asn Tyr Leu Glu Leu Thr Asn Leu Lys 
        115                 120                 125             

Asp Arg Tyr Ile Asn Ser Leu Ser Gly Gly Gln Leu Gln Arg Val Phe 
    130                 135                 140                 

Ile Ala Met Val Leu Ala Gln Asp Thr Asp Phe Ile Leu Leu Asp Glu 
145                 150                 155                 160 

Pro Leu Asn Asn Leu Asp Ile Lys Gln Ser Val Ser Met Met Gln Ile 
                165                 170                 175     

Leu Arg Arg Leu Val Glu Glu Leu Gly Lys Thr Ile Ile Ile Val Leu 
            180                 185                 190         

His Asp Ile Asn Met Ala Ser Gln Tyr Ala Asp Glu Ile Val Ala Phe 
        195                 200                 205             

Lys Asp Gly Gln Val Phe Ser Lys Gly Arg Thr Asp Gln Ile Met Gln 
    210                 215                 220                 

Ala Asp Leu Leu Ser Gln Leu Tyr Glu Ile Pro Ile Thr Leu Ala Asp 
225                 230                 235                 240 

Ile Asn Asp Lys Lys Ile Cys Ile Tyr Ser 
                245                 250 

<210>   3883
<211>   963
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3883
atgaaaacat cccttaaact ttatttcact gccctagtgg ccagcttctt gctcctactt   60
ggtgcatgta gtacaaactc aagcactagt cagacagaga ccagtagctc tgctccaaca   120
gaggtaacca ttaaaagttc actggacgag gtcaaacttt ccaaagttcc tgaaaagatt   180
gtgacctttg acctcggcgc tgcggatact attcgcgctt taggatttga aaaaaatatc   240
gtcggaatgc ctacaaaaac tgttccgact tatctaaaag acctagtggg aactgtcaaa   300
aatgttggtt ctatgaaaga acctgattta gaagctatcg ccgcccttga gcctgatttg   360
attatcgctt cgccacgtac acaaaaattc gtagacaaat tcaaagaaat cgccccaacc   420
gttctcttcc aagcaagcaa ggacgactac tggacttcta ccaaggctaa tatcgaatcc   480
ttagcaagtg ccttcggcga aactggtaca cagaaagcca aggaagaatt gaccaagcta   540
gacaagagca tccaagaagt cgctactaaa aatgaaagct ctgacaaaaa agcccttgcg   600
atcctcctta atgaaggaaa aatggcagcc tttggtgcca aatctcgttt ctctttcttg   660
taccaaacct tgaaattcaa accaactgat acaaaatttg aagactcacg ccacggacaa   720
gaagtcagct ttgaaagtgt caaagaaatc aaccctgaca tcctctttgt catcaaccgt   780
acccttgcca tcggtgggga caactctagc aacgacggtg tcctagaaaa tgcccttatc   840
gctgaaacac ctgctgctaa aaatggtaag attatccaac taacaccaga cctctggtat   900
ctaagcggag gcggacttga atcaacaaaa ctcatgattg aagacataca aaaagctttg   960
aaa                                                                 963

<210>   3884
<211>   321
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   iron-compound ABC transporter, iron-compound-binding protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903729 (e-177)

<400>   3884
Met Lys Thr Ser Leu Lys Leu Tyr Phe Thr Ala Leu Val Ala Ser Phe 
1               5                   10                  15      

Leu Leu Leu Leu Gly Ala Cys Ser Thr Asn Ser Ser Thr Ser Gln Thr 
            20                  25                  30          

Glu Thr Ser Ser Ser Ala Pro Thr Glu Val Thr Ile Lys Ser Ser Leu 
        35                  40                  45              

Asp Glu Val Lys Leu Ser Lys Val Pro Glu Lys Ile Val Thr Phe Asp 
    50                  55                  60                  

Leu Gly Ala Ala Asp Thr Ile Arg Ala Leu Gly Phe Glu Lys Asn Ile 
65                  70                  75                  80  

Val Gly Met Pro Thr Lys Thr Val Pro Thr Tyr Leu Lys Asp Leu Val 
                85                  90                  95      

Gly Thr Val Lys Asn Val Gly Ser Met Lys Glu Pro Asp Leu Glu Ala 
            100                 105                 110         

Ile Ala Ala Leu Glu Pro Asp Leu Ile Ile Ala Ser Pro Arg Thr Gln 
        115                 120                 125             

Lys Phe Val Asp Lys Phe Lys Glu Ile Ala Pro Thr Val Leu Phe Gln 
    130                 135                 140                 

Ala Ser Lys Asp Asp Tyr Trp Thr Ser Thr Lys Ala Asn Ile Glu Ser 
145                 150                 155                 160 

Leu Ala Ser Ala Phe Gly Glu Thr Gly Thr Gln Lys Ala Lys Glu Glu 
                165                 170                 175     

Leu Thr Lys Leu Asp Lys Ser Ile Gln Glu Val Ala Thr Lys Asn Glu 
            180                 185                 190         

Ser Ser Asp Lys Lys Ala Leu Ala Ile Leu Leu Asn Glu Gly Lys Met 
        195                 200                 205             

Ala Ala Phe Gly Ala Lys Ser Arg Phe Ser Phe Leu Tyr Gln Thr Leu 
    210                 215                 220                 

Lys Phe Lys Pro Thr Asp Thr Lys Phe Glu Asp Ser Arg His Gly Gln 
225                 230                 235                 240 

Glu Val Ser Phe Glu Ser Val Lys Glu Ile Asn Pro Asp Ile Leu Phe 
                245                 250                 255     

Val Ile Asn Arg Thr Leu Ala Ile Gly Gly Asp Asn Ser Ser Asn Asp 
            260                 265                 270         

Gly Val Leu Glu Asn Ala Leu Ile Ala Glu Thr Pro Ala Ala Lys Asn 
        275                 280                 285             

Gly Lys Ile Ile Gln Leu Thr Pro Asp Leu Trp Tyr Leu Ser Gly Gly 
    290                 295                 300                 

Gly Leu Glu Ser Thr Lys Leu Met Ile Glu Asp Ile Gln Lys Ala Leu 
305                 310                 315                 320 

Lys 
    

<210>   3885
<211>   153
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3885
gtgaacttga taggatgcgt tttagaatgt caaaatttta tactcttcga aaatctcttc   60
aaaccgcgtc agctttcatc tgcaacctca aaacagtgtt ttgagcaacc tgcggctagt   120
ttcctagttt gctctttgat tttcattgag tat                                153

<210>   3886
<211>   51
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3886
Met Asn Leu Ile Gly Cys Val Leu Glu Cys Gln Asn Phe Ile Leu Phe 
1               5                   10                  15      

Glu Asn Leu Phe Lys Pro Arg Gln Leu Ser Ser Ala Thr Ser Lys Gln 
            20                  25                  30          

Cys Phe Glu Gln Pro Ala Ala Ser Phe Leu Val Cys Ser Leu Ile Phe 
        35                  40                  45              

Ile Glu Tyr 
    50      

<210>   3887
<211>   240
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3887
atgaaacgaa ttttaatagc gcctgtgcgc ttttaccaac gttttatctc accagtcttt   60
ccaccctctt gtcgctttga gctgacttgt tccaactaca tgattcaggc tattgaaaaa   120
catgggttta agggggtatt gatgggcttg gctcggattt tacgttgtca tccctggtcg   180
aaaacaggta aggaccccgt tccagaccgc ttttccctta aacgaaatca agaaggggaa   240

<210>   3888
<211>   80
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903730 (3.E-43)

<400>   3888
Met Lys Arg Ile Leu Ile Ala Pro Val Arg Phe Tyr Gln Arg Phe Ile 
1               5                   10                  15      

Ser Pro Val Phe Pro Pro Ser Cys Arg Phe Glu Leu Thr Cys Ser Asn 
            20                  25                  30          

Tyr Met Ile Gln Ala Ile Glu Lys His Gly Phe Lys Gly Val Leu Met 
        35                  40                  45              

Gly Leu Ala Arg Ile Leu Arg Cys His Pro Trp Ser Lys Thr Gly Lys 
    50                  55                  60                  

Asp Pro Val Pro Asp Arg Phe Ser Leu Lys Arg Asn Gln Glu Gly Glu 
65                  70                  75                  80  


<210>   3889
<211>   720
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3889
atgagaatca ataagtatat tgcccacgca ggtgtggcca gtaggagaaa agcagaagag   60
ctgattaagc aaggcttggt gacggttaac ggccaagtgg tgcgtgaact agcaaccact   120
atcaagtcag gcgacaaggt cgaagttgaa ggtcaaccta tctacaacga agaaaaggtc   180
tactatctgc ttaacaaacc acgcggtgtg atttccagtg tgacagatga taagggtcgc   240
aagacggttg tcgacctctt gcccaatgtc aaagagcgta tttaccctgt gggtcgtttg   300
gactgggata catcaggtgt cttgattttg accaatgatg gggactttac agacgagatg   360
attcaccctc gtaatgagat tgacaaggtt tatgtcgcgc gtgttaaagg tgtggccaat   420
aaggacaatc tccgcccctt gacccgtggt cttgagattg atggtaagaa aaccaagcca   480
gctgtttatg aaattctcaa agtggaccca gtcaaaaatc gctctgtggt gcagttgacc   540
atccatgaag ggcgtaacca tcaggttaaa aagatgtttg aagctgttgg tctccaagta   600
gataagttgt ctcggactcg tttcggacac ctagacttga caggactccg tccaggagaa   660
tcccgtcgtc ttaataaaaa agaaatcagc caactacaca ccatggctgt aactaagaaa   720

<210>   3890
<211>   240
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal large subunit pseudouridine synthase B (rluB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903731 (e-135)

<400>   3890
Met Arg Ile Asn Lys Tyr Ile Ala His Ala Gly Val Ala Ser Arg Arg 
1               5                   10                  15      

Lys Ala Glu Glu Leu Ile Lys Gln Gly Leu Val Thr Val Asn Gly Gln 
            20                  25                  30          

Val Val Arg Glu Leu Ala Thr Thr Ile Lys Ser Gly Asp Lys Val Glu 
        35                  40                  45              

Val Glu Gly Gln Pro Ile Tyr Asn Glu Glu Lys Val Tyr Tyr Leu Leu 
    50                  55                  60                  

Asn Lys Pro Arg Gly Val Ile Ser Ser Val Thr Asp Asp Lys Gly Arg 
65                  70                  75                  80  

Lys Thr Val Val Asp Leu Leu Pro Asn Val Lys Glu Arg Ile Tyr Pro 
                85                  90                  95      

Val Gly Arg Leu Asp Trp Asp Thr Ser Gly Val Leu Ile Leu Thr Asn 
            100                 105                 110         

Asp Gly Asp Phe Thr Asp Glu Met Ile His Pro Arg Asn Glu Ile Asp 
        115                 120                 125             

Lys Val Tyr Val Ala Arg Val Lys Gly Val Ala Asn Lys Asp Asn Leu 
    130                 135                 140                 

Arg Pro Leu Thr Arg Gly Leu Glu Ile Asp Gly Lys Lys Thr Lys Pro 
145                 150                 155                 160 

Ala Val Tyr Glu Ile Leu Lys Val Asp Pro Val Lys Asn Arg Ser Val 
                165                 170                 175     

Val Gln Leu Thr Ile His Glu Gly Arg Asn His Gln Val Lys Lys Met 
            180                 185                 190         

Phe Glu Ala Val Gly Leu Gln Val Asp Lys Leu Ser Arg Thr Arg Phe 
        195                 200                 205             

Gly His Leu Asp Leu Thr Gly Leu Arg Pro Gly Glu Ser Arg Arg Leu 
    210                 215                 220                 

Asn Lys Lys Glu Ile Ser Gln Leu His Thr Met Ala Val Thr Lys Lys 
225                 230                 235                 240 


<210>   3891
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3891
atgagtactt tagcaaaaat agaagcgctc ttgtttgtag cgggtgaaga tgggattcgg   60
gtccgccagt tagctgaact cctctctctg ccaccgacag gcatccagca aagtttagga   120
aaattagccc agaagtatga aaaggaccca gattccagtt tggctttgat tgagacaagt   180
ggtgcttata gattggtgac caagcctcaa tttgcagaga ttttgaagga atactctaag   240
gcgcctatca accagagctt gtctcgggct gcccttgaga ccttgtccat tattgcctac   300
aaacagccga ttacgcggat agaaattgat gccatccgtg gagttaactc gagtggagcc   360
ttggcaaagt tgcaggcttt tgacctgata aaggaagacg ggaaaaagga agtattgggg   420
cgccccaacc tctatgtgac tacggattat ttcctagatt acatggggat aaaccattta   480
gaagaattac cagtgattga tgagcttgag attcaagccc aagaaagcca attatttggt   540
gaaaggatag aagaagatga gaatcaa                                       567

<210>   3892
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903732 (e-102)

<400>   3892
Met Ser Thr Leu Ala Lys Ile Glu Ala Leu Leu Phe Val Ala Gly Glu 
1               5                   10                  15      

Asp Gly Ile Arg Val Arg Gln Leu Ala Glu Leu Leu Ser Leu Pro Pro 
            20                  25                  30          

Thr Gly Ile Gln Gln Ser Leu Gly Lys Leu Ala Gln Lys Tyr Glu Lys 
        35                  40                  45              

Asp Pro Asp Ser Ser Leu Ala Leu Ile Glu Thr Ser Gly Ala Tyr Arg 
    50                  55                  60                  

Leu Val Thr Lys Pro Gln Phe Ala Glu Ile Leu Lys Glu Tyr Ser Lys 
65                  70                  75                  80  

Ala Pro Ile Asn Gln Ser Leu Ser Arg Ala Ala Leu Glu Thr Leu Ser 
                85                  90                  95      

Ile Ile Ala Tyr Lys Gln Pro Ile Thr Arg Ile Glu Ile Asp Ala Ile 
            100                 105                 110         

Arg Gly Val Asn Ser Ser Gly Ala Leu Ala Lys Leu Gln Ala Phe Asp 
        115                 120                 125             

Leu Ile Lys Glu Asp Gly Lys Lys Glu Val Leu Gly Arg Pro Asn Leu 
    130                 135                 140                 

Tyr Val Thr Thr Asp Tyr Phe Leu Asp Tyr Met Gly Ile Asn His Leu 
145                 150                 155                 160 

Glu Glu Leu Pro Val Ile Asp Glu Leu Glu Ile Gln Ala Gln Glu Ser 
                165                 170                 175     

Gln Leu Phe Gly Glu Arg Ile Glu Glu Asp Glu Asn Gln 
            180                 185                 

<210>   3893
<211>   726
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3893
atggatatta aattaaaaga ttttgaagga cccctggact tgctcttgca tctggtttct   60
aagtaccaga tggatatcta cgatgtgccc attacggaag tcatcgaaca gtatctagcc   120
tatgtctcaa ccctgcaggc catgcgtctg gaagtgacgg gtgagtacat ggtcatggct   180
agtcagctca tgctgattaa gagtcgtaaa ctccttccga aggtagcaga agtgacagac   240
ttgggggatg acctggagca ggacctcctc tctcaaatcg aagaatatcg caagttcaag   300
ctcttgggtg agcacttgga agccaagcac caagaacggg cccagtatta ttccaaagcg   360
ccgacagagt tgatttacga agatgcggag cttgtgcatg acaagacgac cattgacctc   420
tttttgactt tttcaaatat cctagccaag aaaaaagagg agtttgcaca aaatcacacg   480
acgatcttgc gggatgagta taagattgag gacatgatga ttatcgtgaa agagtccttg   540
attggacgag atcaattgcg cttgcaggat ttgttcaagg aagcccagaa tgtccaagag   600
gtcatcaccc tctttttggc aaccctagag ttaatcaaaa cccaggagtt gatcctcgtg   660
caagaggaga gttttggaga tatctatctc atggaaaaga aggaagaaag tcaagtgcct   720
caaagc                                                              726

<210>   3894
<211>   242
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903733 (e-132)

<400>   3894
Met Asp Ile Lys Leu Lys Asp Phe Glu Gly Pro Leu Asp Leu Leu Leu 
1               5                   10                  15      

His Leu Val Ser Lys Tyr Gln Met Asp Ile Tyr Asp Val Pro Ile Thr 
            20                  25                  30          

Glu Val Ile Glu Gln Tyr Leu Ala Tyr Val Ser Thr Leu Gln Ala Met 
        35                  40                  45              

Arg Leu Glu Val Thr Gly Glu Tyr Met Val Met Ala Ser Gln Leu Met 
    50                  55                  60                  

Leu Ile Lys Ser Arg Lys Leu Leu Pro Lys Val Ala Glu Val Thr Asp 
65                  70                  75                  80  

Leu Gly Asp Asp Leu Glu Gln Asp Leu Leu Ser Gln Ile Glu Glu Tyr 
                85                  90                  95      

Arg Lys Phe Lys Leu Leu Gly Glu His Leu Glu Ala Lys His Gln Glu 
            100                 105                 110         

Arg Ala Gln Tyr Tyr Ser Lys Ala Pro Thr Glu Leu Ile Tyr Glu Asp 
        115                 120                 125             

Ala Glu Leu Val His Asp Lys Thr Thr Ile Asp Leu Phe Leu Thr Phe 
    130                 135                 140                 

Ser Asn Ile Leu Ala Lys Lys Lys Glu Glu Phe Ala Gln Asn His Thr 
145                 150                 155                 160 

Thr Ile Leu Arg Asp Glu Tyr Lys Ile Glu Asp Met Met Ile Ile Val 
                165                 170                 175     


Lys Glu Ser Leu Ile Gly Arg Asp Gln Leu Arg Leu Gln Asp Leu Phe 
            180                 185                 190         

Lys Glu Ala Gln Asn Val Gln Glu Val Ile Thr Leu Phe Leu Ala Thr 
        195                 200                 205             

Leu Glu Leu Ile Lys Thr Gln Glu Leu Ile Leu Val Gln Glu Glu Ser 
    210                 215                 220                 

Phe Gly Asp Ile Tyr Leu Met Glu Lys Lys Glu Glu Ser Gln Val Pro 
225                 230                 235                 240 

Gln Ser 
        

<210>   3895
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3895
atgccaatga gagacaggat ttcagccttt ttagaggaaa agcagggctt gtctgtcaat   60
tccaagcagt cctataagta tgatttggag caatttttag acatggtagg tgagcggatt   120
tctgagacca gtctcaagat ttaccaagcc cagctagcca atctaaaaat cagcgcccag   180
aagcgaaaga tttcggcctg taaccaattt ctatactttc tctatcaaaa aggagaggtg   240
gacagctttt accgcttgga attagccaaa caagctgaaa agaagacgga aaagccagag   300
attctatacc tagactcttt ttggcaggaa agcgaccatc cagagggccg cttgctagcg   360
ctcttaatcc tagaaatggg gctcttgccc agtgagattt tagccatcaa ggttgcggac   420
atcaatctgg attttcaggt gttgcgaatc agcaaggctt cccaacagag gattgtcacc   480
attcccacgg ccttgctttc agaattggaa cccttgatgg ggcagaccta tctttttgaa   540
agaggagaga aaccctattc tcgtcagtgg gcctttcgtc agttagaatc ttttgtcaag   600
gagaaaggtt ttccatcctt atcagctcaa gtcttacgtg aacagtttat tctaagacaa   660
atagaaaaca aggtcgattt gtacgaaatt gcaaaaaaat taggattaaa aacagtcctg   720
accttagaaa aatataga                                                 738

<210>   3896
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   integrase/recombinase, phage integrase family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903734 (e-136)

<400>   3896
Met Pro Met Arg Asp Arg Ile Ser Ala Phe Leu Glu Glu Lys Gln Gly 
1               5                   10                  15      

Leu Ser Val Asn Ser Lys Gln Ser Tyr Lys Tyr Asp Leu Glu Gln Phe 
            20                  25                  30          

Leu Asp Met Val Gly Glu Arg Ile Ser Glu Thr Ser Leu Lys Ile Tyr 
        35                  40                  45              

Gln Ala Gln Leu Ala Asn Leu Lys Ile Ser Ala Gln Lys Arg Lys Ile 
    50                  55                  60                  

Ser Ala Cys Asn Gln Phe Leu Tyr Phe Leu Tyr Gln Lys Gly Glu Val 
65                  70                  75                  80  

Asp Ser Phe Tyr Arg Leu Glu Leu Ala Lys Gln Ala Glu Lys Lys Thr 
                85                  90                  95      

Glu Lys Pro Glu Ile Leu Tyr Leu Asp Ser Phe Trp Gln Glu Ser Asp 
            100                 105                 110         

His Pro Glu Gly Arg Leu Leu Ala Leu Leu Ile Leu Glu Met Gly Leu 
        115                 120                 125             

Leu Pro Ser Glu Ile Leu Ala Ile Lys Val Ala Asp Ile Asn Leu Asp 
    130                 135                 140                 

Phe Gln Val Leu Arg Ile Ser Lys Ala Ser Gln Gln Arg Ile Val Thr 
145                 150                 155                 160 

Ile Pro Thr Ala Leu Leu Ser Glu Leu Glu Pro Leu Met Gly Gln Thr 
                165                 170                 175     

Tyr Leu Phe Glu Arg Gly Glu Lys Pro Tyr Ser Arg Gln Trp Ala Phe 
            180                 185                 190         

Arg Gln Leu Glu Ser Phe Val Lys Glu Lys Gly Phe Pro Ser Leu Ser 
        195                 200                 205             

Ala Gln Val Leu Arg Glu Gln Phe Ile Leu Arg Gln Ile Glu Asn Lys 
    210                 215                 220                 

Val Asp Leu Tyr Glu Ile Ala Lys Lys Leu Gly Leu Lys Thr Val Leu 
225                 230                 235                 240 

Thr Leu Glu Lys Tyr Arg 
                245     

<210>   3897
<211>   459
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3897
atgattgcca aggagtttga gactttcttg ttggggcagg aggaaacttt tttgacccct   60
gctaaaaatc tagctgtgtt gattgatacc cacaatgcgg atcatgcgac cctcttgctc   120
agtcagatga cctatacccg tgttcccgtt gtgacagatg aaaaacagtt tgttgggacg   180
attggactca gagatattat ggcttatcag atggagcatg acttgagcca agaaatcatg   240
gcggatacgg atatcgttca tatgacaaaa acggacgtag cggttgtttc gcctgatttc   300
accattacgg aggtcttgca caagctagta gatgagtcct tcttaccggt tgtggatgca   360
gagggtattt tccaagggat tattacgcgc aagtccatcc tcaaggccgt taatgccctc   420
ttgcatgact ttagtaagga atatgagatt cgatgccaa                          459

<210>   3898
<211>   153
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   CBS domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903735 (1.E-83)

<400>   3898
Met Ile Ala Lys Glu Phe Glu Thr Phe Leu Leu Gly Gln Glu Glu Thr 
1               5                   10                  15      

Phe Leu Thr Pro Ala Lys Asn Leu Ala Val Leu Ile Asp Thr His Asn 
            20                  25                  30          

Ala Asp His Ala Thr Leu Leu Leu Ser Gln Met Thr Tyr Thr Arg Val 
        35                  40                  45              

Pro Val Val Thr Asp Glu Lys Gln Phe Val Gly Thr Ile Gly Leu Arg 
    50                  55                  60                  

Asp Ile Met Ala Tyr Gln Met Glu His Asp Leu Ser Gln Glu Ile Met 
65                  70                  75                  80  

Ala Asp Thr Asp Ile Val His Met Thr Lys Thr Asp Val Ala Val Val 
                85                  90                  95      

Ser Pro Asp Phe Thr Ile Thr Glu Val Leu His Lys Leu Val Asp Glu 
            100                 105                 110         

Ser Phe Leu Pro Val Val Asp Ala Glu Gly Ile Phe Gln Gly Ile Ile 
        115                 120                 125             

Thr Arg Lys Ser Ile Leu Lys Ala Val Asn Ala Leu Leu His Asp Phe 
    130                 135                 140                 

Ser Lys Glu Tyr Glu Ile Arg Cys Gln 
145                 150             

<210>   3899
<211>   519
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3899
atggcaaagc aaaccatcat tgtaatgagc gattcccatg gcgatagctt gattgtggaa   60
gaagtccgtg atcgctatgt gggcaaagtc gatgctgttt ttcataacgg cgattctgaa   120
ctacgtccgg attctccact ttgggagggc atccgcgttg ttaaagggaa catggacttc   180
tacgccggct acccagaacg tctggtgact gagcttggtt cgaccaagat tatccaaact   240
catggtcact tgtttgacat caatttcaac tttcaaaagt tggactactg ggctcaggag   300
gaagaggccg ctatctgcct ctatggtcac ttgcatgtgc caagtgcttg gttggaaggc   360
aagatcctct ttctaaatcc aggttctatc agtcaaccac gaggtaccat cagagaatgt   420
ctctatgctc gtgtggagat tgatgatagt tacttcaaag tggacttttt gacacgagat   480
cacgaggtgt atccaggttt gtccaaggag tttagccga                          519

<210>   3900
<211>   173
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903736 (e-101)

<400>   3900
Met Ala Lys Gln Thr Ile Ile Val Met Ser Asp Ser His Gly Asp Ser 
1               5                   10                  15      

Leu Ile Val Glu Glu Val Arg Asp Arg Tyr Val Gly Lys Val Asp Ala 
            20                  25                  30          

Val Phe His Asn Gly Asp Ser Glu Leu Arg Pro Asp Ser Pro Leu Trp 
        35                  40                  45              

Glu Gly Ile Arg Val Val Lys Gly Asn Met Asp Phe Tyr Ala Gly Tyr 
    50                  55                  60                  

Pro Glu Arg Leu Val Thr Glu Leu Gly Ser Thr Lys Ile Ile Gln Thr 
65                  70                  75                  80  

His Gly His Leu Phe Asp Ile Asn Phe Asn Phe Gln Lys Leu Asp Tyr 
                85                  90                  95      

Trp Ala Gln Glu Glu Glu Ala Ala Ile Cys Leu Tyr Gly His Leu His 
            100                 105                 110         

Val Pro Ser Ala Trp Leu Glu Gly Lys Ile Leu Phe Leu Asn Pro Gly 
        115                 120                 125             

Ser Ile Ser Gln Pro Arg Gly Thr Ile Arg Glu Cys Leu Tyr Ala Arg 
    130                 135                 140                 

Val Glu Ile Asp Asp Ser Tyr Phe Lys Val Asp Phe Leu Thr Arg Asp 
145                 150                 155                 160 

His Glu Val Tyr Pro Gly Leu Ser Lys Glu Phe Ser Arg 
                165                 170             

<210>   3901
<211>   738
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3901
atgggacgaa acttggaagt tattcaacgt catggggccc tgctcttggt tgaaaatggg   60
caactcttgt atgtagaatt gcctaaagaa ggggtcaatg ttcatgattt ctttgagaca   120
agcaaggtca gagaaacctt gttgattgcg actcgtaacg aaggtaaaac caaggaattc   180
cgagctatct ttgataagtt aggctacgat gtggaaaatc ttaatgacta ccctgacctg   240
cctgaagtag cagaaacagg tatgaccttt gaagaaaatg cccgccttaa ggcagaaacc   300
atttctcaat taacgggcaa gatggttttg gcagatgatt ctggtctcaa agtcgatgtc   360
cttggtggct taccaggcgt ctggtcagct cgtttcgcag gtgtgggagc aactgaccgt   420
gaaaataatg ccaaactctt gcacgaattg gccatggtct ttgaactcaa ggaccgctcg   480
gctcagttcc acacaaccct agtcgtagcc agcccaaata aggaaagttt agttgttgaa   540
gcagactggt caggttatat taactttgaa cctaagggtg aaaatggctt tggctatgat   600
cccctcttcc ttgtaggaga aacaggtgag tcatcagctg aattaaccct ggaagaaaaa   660
aatagtcaat ctcaccgtgc cttagccgtt aagaaacttt tggaggtatt tccatcatgg   720
caaagcaaac catcattg                                                 738

<210>   3902
<211>   246
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   HAM1 protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903737 (e-112)

<400>   3902
Met Gly Arg Asn Leu Glu Val Ile Gln Arg His Gly Ala Leu Leu Leu 
1               5                   10                  15      

Val Glu Asn Gly Gln Leu Leu Tyr Val Glu Leu Pro Lys Glu Gly Val 
            20                  25                  30          

Asn Val His Asp Phe Phe Glu Thr Ser Lys Val Arg Glu Thr Leu Leu 
        35                  40                  45              

Ile Ala Thr Arg Asn Glu Gly Lys Thr Lys Glu Phe Arg Ala Ile Phe 
    50                  55                  60                  

Asp Lys Leu Gly Tyr Asp Val Glu Asn Leu Asn Asp Tyr Pro Asp Leu 
65                  70                  75                  80  

Pro Glu Val Ala Glu Thr Gly Met Thr Phe Glu Glu Asn Ala Arg Leu 
                85                  90                  95      

Lys Ala Glu Thr Ile Ser Gln Leu Thr Gly Lys Met Val Leu Ala Asp 
            100                 105                 110         

Asp Ser Gly Leu Lys Val Asp Val Leu Gly Gly Leu Pro Gly Val Trp 
        115                 120                 125             

Ser Ala Arg Phe Ala Gly Val Gly Ala Thr Asp Arg Glu Asn Asn Ala 
    130                 135                 140                 

Lys Leu Leu His Glu Leu Ala Met Val Phe Glu Leu Lys Asp Arg Ser 
145                 150                 155                 160 

Ala Gln Phe His Thr Thr Leu Val Val Ala Ser Pro Asn Lys Glu Ser 
                165                 170                 175     

Leu Val Val Glu Ala Asp Trp Ser Gly Tyr Ile Asn Phe Glu Pro Lys 
            180                 185                 190         


Gly Glu Asn Gly Phe Gly Tyr Asp Pro Leu Phe Leu Val Gly Glu Thr 
        195                 200                 205             

Gly Glu Ser Ser Ala Glu Leu Thr Leu Glu Glu Lys Asn Ser Gln Ser 
    210                 215                 220                 

His Arg Ala Leu Ala Val Lys Lys Leu Leu Glu Val Phe Pro Ser Trp 
225                 230                 235                 240 

Gln Ser Lys Pro Ser Leu 
                245     

<210>   3903
<211>   792
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3903
atggataatc gaccaattgg ttttttggat tcgggtgtcg ggggcttgac cgttgtgcgc   60
gagctcatgc gccagcttcc ccatgaagaa atcgtctata ttggagattc ggcgcgggcg   120
ccctatggcc cccgtcctgc tgagcaaatt cgtgaatata cttggcagct ggtcaacttt   180
ctcttgacca aggatgtcaa aatgattgtc attgcttgta acactgcgac tgcggtcgtc   240
tgggaagaaa tcaaggctca actagatatt cctgtcttgg gtgtaatttt gccaggagct   300
tcggcagcca tcaagtccag tcaaggtggg aaaatcggag tgattggaac gcccatgacg   360
gtacaatcag acatataccg tcagaaaatc catgatctgg atcccgactt acaggtggag   420
agcttggcct gtcccaagtt tgctcccttg gttgagtcag gtgccctgtc aaccagtgtt   480
accaagaagg tggtctatga aaccctgcgt cccttggttg gaaaggtgga tagcctgatt   540
ttgggctgta ctcattatcc actccttcgc cctattatcc aaaatgtgat ggggccaaag   600
gttcagctca tcgatagtgg ggcagagtgc gtacgggata tctcagtctt actcaattat   660
tttgaaatca atcgtggtcg cgatgctgga ccactccatc accgttttta cacaacagcc   720
agtagccaaa gttttgcaca aattggtgaa gaatggctgg aaaaagagat tcatgtggag   780
catgtagaat ta                                                       792

<210>   3904
<211>   264
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamate racemase (murI)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903738 (e-152)

<400>   3904
Met Asp Asn Arg Pro Ile Gly Phe Leu Asp Ser Gly Val Gly Gly Leu 
1               5                   10                  15      

Thr Val Val Arg Glu Leu Met Arg Gln Leu Pro His Glu Glu Ile Val 
            20                  25                  30          

Tyr Ile Gly Asp Ser Ala Arg Ala Pro Tyr Gly Pro Arg Pro Ala Glu 
        35                  40                  45              

Gln Ile Arg Glu Tyr Thr Trp Gln Leu Val Asn Phe Leu Leu Thr Lys 
    50                  55                  60                  

Asp Val Lys Met Ile Val Ile Ala Cys Asn Thr Ala Thr Ala Val Val 
65                  70                  75                  80  

Trp Glu Glu Ile Lys Ala Gln Leu Asp Ile Pro Val Leu Gly Val Ile 
                85                  90                  95      

Leu Pro Gly Ala Ser Ala Ala Ile Lys Ser Ser Gln Gly Gly Lys Ile 
            100                 105                 110         

Gly Val Ile Gly Thr Pro Met Thr Val Gln Ser Asp Ile Tyr Arg Gln 
        115                 120                 125             

Lys Ile His Asp Leu Asp Pro Asp Leu Gln Val Glu Ser Leu Ala Cys 
    130                 135                 140                 

Pro Lys Phe Ala Pro Leu Val Glu Ser Gly Ala Leu Ser Thr Ser Val 
145                 150                 155                 160 

Thr Lys Lys Val Val Tyr Glu Thr Leu Arg Pro Leu Val Gly Lys Val 
                165                 170                 175     

Asp Ser Leu Ile Leu Gly Cys Thr His Tyr Pro Leu Leu Arg Pro Ile 
            180                 185                 190         

Ile Gln Asn Val Met Gly Pro Lys Val Gln Leu Ile Asp Ser Gly Ala 
        195                 200                 205             

Glu Cys Val Arg Asp Ile Ser Val Leu Leu Asn Tyr Phe Glu Ile Asn 
    210                 215                 220                 

Arg Gly Arg Asp Ala Gly Pro Leu His His Arg Phe Tyr Thr Thr Ala 
225                 230                 235                 240 

Ser Ser Gln Ser Phe Ala Gln Ile Gly Glu Glu Trp Leu Glu Lys Glu 
                245                 250                 255     

Ile His Val Glu His Val Glu Leu 
            260                 

<210>   3905
<211>   246
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3905
atggatttac ttttagcaat tgtattgatt gtgctagctt ttctaggagg agctctagga   60
ggaatgtact tggttcgtaa gcaaatcgaa aaagaatttg ctgacaaccc acgtttgaat   120
gctgaagcag ttcgtactct tttgagtgca aatggtcaaa aaccaagcga agctaaggta   180
caacaagttt accaccaaat catccgccaa caaaaggcag cccttgctaa caataaaaag   240
aaaaaa                                                              246

<210>   3906
<211>   82
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903739 (5.E-41)

<400>   3906
Met Asp Leu Leu Leu Ala Ile Val Leu Ile Val Leu Ala Phe Leu Gly 
1               5                   10                  15      

Gly Ala Leu Gly Gly Met Tyr Leu Val Arg Lys Gln Ile Glu Lys Glu 
            20                  25                  30          

Phe Ala Asp Asn Pro Arg Leu Asn Ala Glu Ala Val Arg Thr Leu Leu 
        35                  40                  45              

Ser Ala Asn Gly Gln Lys Pro Ser Glu Ala Lys Val Gln Gln Val Tyr 
    50                  55                  60                  

His Gln Ile Ile Arg Gln Gln Lys Ala Ala Leu Ala Asn Asn Lys Lys 
65                  70                  75                  80  

Lys Lys 
        

<210>   3907
<211>   1623
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3907
atgacacttg ataaaggaaa agtagtctat caaatctatc caaaatctta caaagacacc   60
actgaaaacg gtattgggga tttccgtggg attatcgaaa aaattcccta tttagccaaa   120
ctaggtgtgg atatggtctg gctcaatcca ttctatccaa gccctcaacg ggataatggt   180
tacgatattt cagattatat ggcagtggat cctctttttg gtgatatggc tgattttgag   240
aaaatggtgt gtgtcggtaa agagcacaag attgacttta tgctggacat ggtacttaat   300
cattgttcga cagagcatga atggtttcag aaagccctag ctggtgataa gtattatcaa   360
gactttttct tcatccaaga ccaaccaaca gattggcagt ctaagtttgg tggttctgca   420
tggacgcctt tcggggatac tgggaaatac tatcttcacc tatttgatga gacccaggct   480
gaccttaact ggcgcaattc caatgtccgt aaggagcttt tcaaggttgt taatttctgg   540
cgcgacaagg gtgtcaaagg tttccgattt gatgtgatca atttgatcgg taaggacgag   600
gtttcagtgg actgtcctga aaatgaaggg aagccagctt atacagacaa acccatcgtt   660
cataactatt tgcgtatgat gaaccaagcc acttttggat ccgacgatag ctttatgaca   720
gttggggaaa tgtcttctac caccatggaa aactgtgtcc tctattcgtc gcctgatcgt   780
caggaattat ccatgacctt taattttcat cacctcaagg tggactataa ggatggacaa   840
aagtggacct tggctccctt tgattttgaa gagttgaaga gtctttacca tagttggggt   900
aaggaaatga gtgataaaga cggttggagt gccctctttt ggaataatca cgatcaacca   960
cgtgccttga accgttttgt cgatattcaa aacttccgca aggaaggagc caccatgcta   1020
gcagccagca ttcacctgtc acgtgggaca ccttatatct acatgggtga ggaaatcggg   1080
atgattgacc cagactatga ttctatggct gattatgtgg atgtcgaatc gcttaatgcc   1140
tatcagatgc tcttagaaga aggaaagagt cagcaagaag ccttccagat tattcaagct   1200
aagtcgcgtg ataattcacg cattcccatg cagtgggatg cttcggaaaa tgcaggattt   1260
tcaacaggca ctccttggtt gaaagctggt aaatcctata aatacatcaa tgtagaaaat   1320
gaaatccagg gtccgatttt taccttctat caagacttga ttcgactgcg taaggaaatg   1380
ccaatcattt cagaaggaag ttacaaacca gcctttgaag atagcaaaca agtctacgct   1440
tttgaacgcc agtttgagga tcaaaagtta ctagtgctca ataactttta tgctaaagaa   1500
gtggaaatcg acttgccagc agtctaccaa aatggacaga ttttgatatc aaactatgaa   1560
gatgcagaag tgtctgagaa aattctactc aaaccctatc aaacactggc tatttatgta   1620
aat                                                                 1623

<210>   3908
<211>   541
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dextran glucosidase DexS, putative, FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903740 (0.E+01)

<400>   3908
Met Thr Leu Asp Lys Gly Lys Val Val Tyr Gln Ile Tyr Pro Lys Ser 
1               5                   10                  15      

Tyr Lys Asp Thr Thr Glu Asn Gly Ile Gly Asp Phe Arg Gly Ile Ile 
            20                  25                  30          

Glu Lys Ile Pro Tyr Leu Ala Lys Leu Gly Val Asp Met Val Trp Leu 
        35                  40                  45              

Asn Pro Phe Tyr Pro Ser Pro Gln Arg Asp Asn Gly Tyr Asp Ile Ser 
    50                  55                  60                  

Asp Tyr Met Ala Val Asp Pro Leu Phe Gly Asp Met Ala Asp Phe Glu 
65                  70                  75                  80  

Lys Met Val Cys Val Gly Lys Glu His Lys Ile Asp Phe Met Leu Asp 
                85                  90                  95      

Met Val Leu Asn His Cys Ser Thr Glu His Glu Trp Phe Gln Lys Ala 
            100                 105                 110         

Leu Ala Gly Asp Lys Tyr Tyr Gln Asp Phe Phe Phe Ile Gln Asp Gln 
        115                 120                 125             

Pro Thr Asp Trp Gln Ser Lys Phe Gly Gly Ser Ala Trp Thr Pro Phe 
    130                 135                 140                 

Gly Asp Thr Gly Lys Tyr Tyr Leu His Leu Phe Asp Glu Thr Gln Ala 
145                 150                 155                 160 

Asp Leu Asn Trp Arg Asn Ser Asn Val Arg Lys Glu Leu Phe Lys Val 
                165                 170                 175     

Val Asn Phe Trp Arg Asp Lys Gly Val Lys Gly Phe Arg Phe Asp Val 
            180                 185                 190         

Ile Asn Leu Ile Gly Lys Asp Glu Val Ser Val Asp Cys Pro Glu Asn 
        195                 200                 205             

Glu Gly Lys Pro Ala Tyr Thr Asp Lys Pro Ile Val His Asn Tyr Leu 
    210                 215                 220                 

Arg Met Met Asn Gln Ala Thr Phe Gly Ser Asp Asp Ser Phe Met Thr 
225                 230                 235                 240 

Val Gly Glu Met Ser Ser Thr Thr Met Glu Asn Cys Val Leu Tyr Ser 
                245                 250                 255     

Ser Pro Asp Arg Gln Glu Leu Ser Met Thr Phe Asn Phe His His Leu 
            260                 265                 270         

Lys Val Asp Tyr Lys Asp Gly Gln Lys Trp Thr Leu Ala Pro Phe Asp 
        275                 280                 285             

Phe Glu Glu Leu Lys Ser Leu Tyr His Ser Trp Gly Lys Glu Met Ser 

    290                 295                 300                 

Asp Lys Asp Gly Trp Ser Ala Leu Phe Trp Asn Asn His Asp Gln Pro 
305                 310                 315                 320 

Arg Ala Leu Asn Arg Phe Val Asp Ile Gln Asn Phe Arg Lys Glu Gly 
                325                 330                 335     

Ala Thr Met Leu Ala Ala Ser Ile His Leu Ser Arg Gly Thr Pro Tyr 
            340                 345                 350         

Ile Tyr Met Gly Glu Glu Ile Gly Met Ile Asp Pro Asp Tyr Asp Ser 
        355                 360                 365             

Met Ala Asp Tyr Val Asp Val Glu Ser Leu Asn Ala Tyr Gln Met Leu 
    370                 375                 380                 

Leu Glu Glu Gly Lys Ser Gln Gln Glu Ala Phe Gln Ile Ile Gln Ala 
385                 390                 395                 400 

Lys Ser Arg Asp Asn Ser Arg Ile Pro Met Gln Trp Asp Ala Ser Glu 
                405                 410                 415     

Asn Ala Gly Phe Ser Thr Gly Thr Pro Trp Leu Lys Ala Gly Lys Ser 
            420                 425                 430         

Tyr Lys Tyr Ile Asn Val Glu Asn Glu Ile Gln Gly Pro Ile Phe Thr 
        435                 440                 445             

Phe Tyr Gln Asp Leu Ile Arg Leu Arg Lys Glu Met Pro Ile Ile Ser 
    450                 455                 460                 

Glu Gly Ser Tyr Lys Pro Ala Phe Glu Asp Ser Lys Gln Val Tyr Ala 
465                 470                 475                 480 

Phe Glu Arg Gln Phe Glu Asp Gln Lys Leu Leu Val Leu Asn Asn Phe 
                485                 490                 495     

Tyr Ala Lys Glu Val Glu Ile Asp Leu Pro Ala Val Tyr Gln Asn Gly 
            500                 505                 510         

Gln Ile Leu Ile Ser Asn Tyr Glu Asp Ala Glu Val Ser Glu Lys Ile 
        515                 520                 525             

Leu Leu Lys Pro Tyr Gln Thr Leu Ala Ile Tyr Val Asn 
    530                 535                 540     

<210>   3909
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3909
gtgctatttc aattatactc aatgaaaatc aaagaacaaa ctaggaagct agccacaggt   60
tgctcaaaac actattttga ggttgcagat agagctgacg tggtt                   105

<210>   3910
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3910
Met Leu Phe Gln Leu Tyr Ser Met Lys Ile Lys Glu Gln Thr Arg Lys 
1               5                   10                  15      

Leu Ala Thr Gly Cys Ser Lys His Tyr Phe Glu Val Ala Asp Arg Ala 
            20                  25                  30          

Asp Val Val 
        35  

<210>   3911
<211>   1965
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3911
atgggaaaat ttgaacaaga agccaaagat ctgcttcagg caatcggagg caaagaaaat   60
gtgactgccg taactcactg tgcgacacgg atgcggtttg ttttaggaga tgataagaag   120
gctaatgtta aagctatcga gtcaattcca gctgttaaag gaacctttac aaatgcaggt   180
caatttcagg taatcattgg aaatgacgtg cccatctttt ataatgattt tacagccgtt   240
tcaggtattg agggtgtttc caaagaagca gccaagtctg cagctaagag taatcaaaac   300
gtggtccaag gtgttatgac cactctggcg gagattttta ctccgattat tccagccttg   360
atagtcggag gattgatcct cggtttccgt aatgtcttgg aaggtgtcca ttggtcgatg   420
ttggatggca agaccatcac agaatcctct cagttttggg caggtgtcaa tcacttcctc   480
tggttgcctg gtgaagctat cttccagttc ttaccagtag ggattacttg gtctgtttct   540
cgtaagatgg gaaccagcca aattttggga attgttctcg gaatctgttt ggtatcgcct   600
cagttgctca atgcctatgc ggttgcttca acgccagcag ctgatatcgc ggcaaactgg   660
gtttggaatt ttggctattt tactgttaat cgtatcggtt accaagccca agttatccca   720
gccttgcttg caggtttgag tctgtcttat cttgaaatct tctggcacaa gcatatccca   780
gaagtcattt ctatgatttt tgtacctttc ttgtcattga ttccagcctt gattttggct   840
catactgttt tgggaccaat cggttggaca attggacaag gactttcatc agttgtcttg   900
gcaggtttaa ctggtccagt taaatggctc ttcggtgcaa tttttggcgc cctctacgct   960
ccatttgtca tcacaggtct gcaccatatg accaatgcca ttgatacaca attgattgcg   1020
gatgctggtg gcactgccct atggccaatg attgctcttt ctaatattgc tcaaggctca   1080
gccgtgtttg cctattattt catgcatcgc catgatgagc gtgaggctca ggtttcactt   1140
cctgcaacca tttcagccta tctcggtgtt acagaaccag ctctttttgg ggttaacgta   1200
aaatatattt atccatttgt tgctgggatg actggttcag cccttgcagg catgttatcc   1260
gttactttta atgtaactgc ggcttctatt ggtatcggtg gtttgccagg tattctctct   1320
attcaacctc aatacatgct gccatttgca ggaactatgc tagttgcgat tgttgttcca   1380
atgctcttga ctttcttctt ccgcaaggct ggtctcttta caaaaacaga gggcgatacg   1440
aacttgcagg cagaattcgt tgctcaagaa gaagcagaat ttgtgaacca tgaaccagta   1500
gaacttactt cggtagaaat tatcagccca ctaactggcc aagtgaaaga attgagtcaa   1560
gcgacggatc ctatttttgc atcaggtgtc atggggcaag gtctagtcat tgaaccaagc   1620
caaggtgagt tgacctctcc agttaatggg acagtgacgg ttcttttccc taccaagcat   1680
gccatcggca ttgtctctga cgagggagtt gaattgctca tccacatcgg tatggataca   1740
gtaggtcttg atggcaaagg ttttgaaagt cttgtagtcc aaggagatca cgttacagtt   1800
ggtcagcaac tgattcgttt tgatatggat gtcattaagg ctgcaggtct ggtgacagaa   1860
actcctgtta tcatcaccaa ccaagatgct tatacagcga ctattcccgg aacttatccg   1920
acaacgatcc aagctggagc atctctcatg gtcgctacac gaatc                   1965

<210>   3912
<211>   655
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIABC components
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903741 (0.E+01)

<400>   3912
Met Gly Lys Phe Glu Gln Glu Ala Lys Asp Leu Leu Gln Ala Ile Gly 
1               5                   10                  15      

Gly Lys Glu Asn Val Thr Ala Val Thr His Cys Ala Thr Arg Met Arg 
            20                  25                  30          

Phe Val Leu Gly Asp Asp Lys Lys Ala Asn Val Lys Ala Ile Glu Ser 
        35                  40                  45              

Ile Pro Ala Val Lys Gly Thr Phe Thr Asn Ala Gly Gln Phe Gln Val 
    50                  55                  60                  

Ile Ile Gly Asn Asp Val Pro Ile Phe Tyr Asn Asp Phe Thr Ala Val 
65                  70                  75                  80  

Ser Gly Ile Glu Gly Val Ser Lys Glu Ala Ala Lys Ser Ala Ala Lys 
                85                  90                  95      

Ser Asn Gln Asn Val Val Gln Gly Val Met Thr Thr Leu Ala Glu Ile 
            100                 105                 110         

Phe Thr Pro Ile Ile Pro Ala Leu Ile Val Gly Gly Leu Ile Leu Gly 
        115                 120                 125             

Phe Arg Asn Val Leu Glu Gly Val His Trp Ser Met Leu Asp Gly Lys 
    130                 135                 140                 

Thr Ile Thr Glu Ser Ser Gln Phe Trp Ala Gly Val Asn His Phe Leu 
145                 150                 155                 160 

Trp Leu Pro Gly Glu Ala Ile Phe Gln Phe Leu Pro Val Gly Ile Thr 
                165                 170                 175     

Trp Ser Val Ser Arg Lys Met Gly Thr Ser Gln Ile Leu Gly Ile Val 
            180                 185                 190         

Leu Gly Ile Cys Leu Val Ser Pro Gln Leu Leu Asn Ala Tyr Ala Val 
        195                 200                 205             

Ala Ser Thr Pro Ala Ala Asp Ile Ala Ala Asn Trp Val Trp Asn Phe 
    210                 215                 220                 

Gly Tyr Phe Thr Val Asn Arg Ile Gly Tyr Gln Ala Gln Val Ile Pro 
225                 230                 235                 240 

Ala Leu Leu Ala Gly Leu Ser Leu Ser Tyr Leu Glu Ile Phe Trp His 
                245                 250                 255     

Lys His Ile Pro Glu Val Ile Ser Met Ile Phe Val Pro Phe Leu Ser 
            260                 265                 270         

Leu Ile Pro Ala Leu Ile Leu Ala His Thr Val Leu Gly Pro Ile Gly 
        275                 280                 285             

Trp Thr Ile Gly Gln Gly Leu Ser Ser Val Val Leu Ala Gly Leu Thr 
    290                 295                 300                 

Gly Pro Val Lys Trp Leu Phe Gly Ala Ile Phe Gly Ala Leu Tyr Ala 
305                 310                 315                 320 

Pro Phe Val Ile Thr Gly Leu His His Met Thr Asn Ala Ile Asp Thr 
                325                 330                 335     

Gln Leu Ile Ala Asp Ala Gly Gly Thr Ala Leu Trp Pro Met Ile Ala 
            340                 345                 350         

Leu Ser Asn Ile Ala Gln Gly Ser Ala Val Phe Ala Tyr Tyr Phe Met 
        355                 360                 365             

His Arg His Asp Glu Arg Glu Ala Gln Val Ser Leu Pro Ala Thr Ile 
    370                 375                 380                 

Ser Ala Tyr Leu Gly Val Thr Glu Pro Ala Leu Phe Gly Val Asn Val 
385                 390                 395                 400 

Lys Tyr Ile Tyr Pro Phe Val Ala Gly Met Thr Gly Ser Ala Leu Ala 
                405                 410                 415     

Gly Met Leu Ser Val Thr Phe Asn Val Thr Ala Ala Ser Ile Gly Ile 
            420                 425                 430         

Gly Gly Leu Pro Gly Ile Leu Ser Ile Gln Pro Gln Tyr Met Leu Pro 
        435                 440                 445             

Phe Ala Gly Thr Met Leu Val Ala Ile Val Val Pro Met Leu Leu Thr 
    450                 455                 460                 

Phe Phe Phe Arg Lys Ala Gly Leu Phe Thr Lys Thr Glu Gly Asp Thr 
465                 470                 475                 480 

Asn Leu Gln Ala Glu Phe Val Ala Gln Glu Glu Ala Glu Phe Val Asn 
                485                 490                 495     

His Glu Pro Val Glu Leu Thr Ser Val Glu Ile Ile Ser Pro Leu Thr 
            500                 505                 510         

Gly Gln Val Lys Glu Leu Ser Gln Ala Thr Asp Pro Ile Phe Ala Ser 
        515                 520                 525             

Gly Val Met Gly Gln Gly Leu Val Ile Glu Pro Ser Gln Gly Glu Leu 
    530                 535                 540                 

Thr Ser Pro Val Asn Gly Thr Val Thr Val Leu Phe Pro Thr Lys His 
545                 550                 555                 560 

Ala Ile Gly Ile Val Ser Asp Glu Gly Val Glu Leu Leu Ile His Ile 
                565                 570                 575     

Gly Met Asp Thr Val Gly Leu Asp Gly Lys Gly Phe Glu Ser Leu Val 
            580                 585                 590         

Val Gln Gly Asp His Val Thr Val Gly Gln Gln Leu Ile Arg Phe Asp 
        595                 600                 605             

Met Asp Val Ile Lys Ala Ala Gly Leu Val Thr Glu Thr Pro Val Ile 
    610                 615                 620                 

Ile Thr Asn Gln Asp Ala Tyr Thr Ala Thr Ile Pro Gly Thr Tyr Pro 
625                 630                 635                 640 

Thr Thr Ile Gln Ala Gly Ala Ser Leu Met Val Ala Thr Arg Ile 
                645                 650                 655 

<210>   3913
<211>   708
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3913
atgaagaaat accaacaatt atttaagcaa atccaagaaa ccattcaaaa cgagacttac   60
gctgtcggag atttccttcc tagcgagcac gaccttatgg agcaatatca agtgagtcgt   120
gataccgtcc gaaaggccct gtctctcctc caagaggaag gattgatcaa aaagataaga   180
gggcaaggtt ctcaagtcgt caaagaagaa accgtcaatt tccctgtatc caacctaacc   240
agctaccaag aactagttaa agaacttgga ctgcgctcta aaaccaacgt ggtcagtctg   300
gacaagatta ttattgataa aaaatcctca ctgataaccg gtttcccaga gtttcggatg   360
gtttggaagg tggtccgcca gcgtgtggtg gatgatctgg tatccgttct ggatacggac   420
tatctggata tggaactcat cccaaatctc actcgccaaa ttgctgagca gtctatctat   480
tcttatatag aaaatggcct caaactcctt attgattatg ctcagaagga aatcaccatt   540
gaccactcaa gcgaccgaga caagattctc atggacattg gcaaagaccc ttatgtcgtt   600
tcgattaaat caaaagtcta tctccaagac ggacgccaat ttcagtttac cgaaagtcgc   660
cataagttag agaaatttag atttgtagat tttgcaaaac gcaagaaa                708

<210>   3914
<211>   236
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   trehalose operon transcriptional repressor (treR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903742 (e-131)

<400>   3914
Met Lys Lys Tyr Gln Gln Leu Phe Lys Gln Ile Gln Glu Thr Ile Gln 
1               5                   10                  15      

Asn Glu Thr Tyr Ala Val Gly Asp Phe Leu Pro Ser Glu His Asp Leu 
            20                  25                  30          

Met Glu Gln Tyr Gln Val Ser Arg Asp Thr Val Arg Lys Ala Leu Ser 
        35                  40                  45              

Leu Leu Gln Glu Glu Gly Leu Ile Lys Lys Ile Arg Gly Gln Gly Ser 
    50                  55                  60                  

Gln Val Val Lys Glu Glu Thr Val Asn Phe Pro Val Ser Asn Leu Thr 
65                  70                  75                  80  

Ser Tyr Gln Glu Leu Val Lys Glu Leu Gly Leu Arg Ser Lys Thr Asn 
                85                  90                  95      

Val Val Ser Leu Asp Lys Ile Ile Ile Asp Lys Lys Ser Ser Leu Ile 
            100                 105                 110         

Thr Gly Phe Pro Glu Phe Arg Met Val Trp Lys Val Val Arg Gln Arg 
        115                 120                 125             

Val Val Asp Asp Leu Val Ser Val Leu Asp Thr Asp Tyr Leu Asp Met 
    130                 135                 140                 

Glu Leu Ile Pro Asn Leu Thr Arg Gln Ile Ala Glu Gln Ser Ile Tyr 
145                 150                 155                 160 


Ser Tyr Ile Glu Asn Gly Leu Lys Leu Leu Ile Asp Tyr Ala Gln Lys 
                165                 170                 175     

Glu Ile Thr Ile Asp His Ser Ser Asp Arg Asp Lys Ile Leu Met Asp 
            180                 185                 190         

Ile Gly Lys Asp Pro Tyr Val Val Ser Ile Lys Ser Lys Val Tyr Leu 
        195                 200                 205             

Gln Asp Gly Arg Gln Phe Gln Phe Thr Glu Ser Arg His Lys Leu Glu 
    210                 215                 220                 

Lys Phe Arg Phe Val Asp Phe Ala Lys Arg Lys Lys 
225                 230                 235     

<210>   3915
<211>   1324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3915
atggaacaat tacattttat cacaaaactg ctcgatatta aagacccaaa catcaagatt   60
ctagacatca tcaatatgga tacccacaaa gaaattatcg ctaagctgga ttatgaggct   120
ccatcttgcc ctgattgtgg aagtctaatg aagaaatatg actttcaaaa accgtctaag   180
atcccttacc tcgaaacaac tggtatgcct actagaattc tccttagaaa gcgtcgtttc   240
aagtgctatc attgttctaa aatgatggtc gctgaaactt ctatcgtcaa gaagaatcat   300
caaattcctc gtattatcaa ccaaaaaatt gcgcaaaagt tgattgagaa gatttctatg   360
accgatattg ctcatcagct ggccatttca acttcaactg tcattcgaaa gctcaatgat   420
tctcactttg agcatgattt ttcgcgtctt cctgagatta tgtcctggga cgttgaaaca   480
gtccggggag tgactgtttc aatcgggaga tggagatgag ctttattgcg caagatttta   540
acaatttcaa tatcatcact gttcttgaag gtagaacaca agctgtcatc cgagatcact   600
ttcttaaata tgatagagcc gtccgatgtc gcgtcaaaat cattactatg gctatgttta   660
gcccttacta tgacttggct aaacagcttc gctttcaaat ttctaggctc aggctgaaac   720
agtctcccag gctgtttcac tcccgaatgc taaaatcgtt cttgatcgct ttcacattgt   780
acaacatctt agccgtgcta tgagtcgtgt gcatgtccaa atcatgaatc agtttcatcg   840
aaaatcccat gaatacaagg ctatcaagcg ctactggaaa ctcattcaac aggatagccg   900
taaactgagt gataagcgat tttatcgccc tacttttcgc atgcacttaa caaataaaga   960
aattcttgac aagattttaa gctattcaga agacttgaaa caccactatc agatctatca   1020
actcttactt tttcactttc agaacaaaga ccctgagaaa tttttcggac tcattgagga   1080
caatctgaag caggttcatc ctctttttca gactgtcttt aaaacctttc tcaaagataa   1140
agaaaagatt atcaacgccc ttcaactaca ctattctaat gccaaactgg aagcgaccaa   1200
taatctcatc aaacttatca agcgcaatgc ctttggtttt cgaaactttg aaaacttcaa   1260
aaaacggatt tttatcgctt tgaacatcaa aaaagaaagg acgaaatttg tcctttctcg   1320
agct                                                                1324

<210>   3916
<211>   172
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase FRAMESHIFT

<400>   3916
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Lys Ile Leu Asp Ile Ile Asn Met Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Glu Ala Pro Ser Cys Pro Asp Cys Gly Ser 
        35                  40                  45              

Leu Met Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser Ile Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ala 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Ser His Phe Glu 
    130                 135                 140                 

His Asp Phe Ser Arg Leu Pro Glu Ile Met Ser Trp Asp Val Glu Thr 
145                 150                 155                 160 

Val Arg Gly Val Thr Val Ser Ile Gly Arg Trp Arg 
                165                 170         

<210>   3917
<211>   285
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3917
atgagcttta ttgcgcaaga ttttaacaat ttcaatatca tcactgttct tgaaggtaga   60
acacaagctg tcatccgaga tcactttctt aaatatgata gagccgtccg atgtcgcgtc   120
aaaatcatta ctatggctat gtttagccct tactatgact tggctaaaca gcttcgcttt   180
caaatttcta ggctcaggct gaaacagtct cccaggctgt ttcactcccg aatgctaaaa   240
tcgttcttga tcgctttcac attgtacaac atcttagccg tgcta                   285

<210>   3918
<211>   95
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase-related

<400>   3918
Met Ser Phe Ile Ala Gln Asp Phe Asn Asn Phe Asn Ile Ile Thr Val 
1               5                   10                  15      

Leu Glu Gly Arg Thr Gln Ala Val Ile Arg Asp His Phe Leu Lys Tyr 
            20                  25                  30          

Asp Arg Ala Val Arg Cys Arg Val Lys Ile Ile Thr Met Ala Met Phe 
        35                  40                  45              

Ser Pro Tyr Tyr Asp Leu Ala Lys Gln Leu Arg Phe Gln Ile Ser Arg 
    50                  55                  60                  

Leu Arg Leu Lys Gln Ser Pro Arg Leu Phe His Ser Arg Met Leu Lys 
65                  70                  75                  80  

Ser Phe Leu Ile Ala Phe Thr Leu Tyr Asn Ile Leu Ala Val Leu 
                85                  90                  95  


<210>   3919
<211>   525
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3919
atgagtcgtg tgcatgtcca aatcatgaat cagtttcatc gaaaatccca tgaatacaag   60
gctatcaagc gctactggaa actcattcaa caggatagcc gtaaactgag tgataagcga   120
ttttatcgcc ctacttttcg catgcactta acaaataaag aaattcttga caagatttta   180
agctattcag aagacttgaa acaccactat cagatctatc aactcttact ttttcacttt   240
cagaacaaag accctgagaa atttttcgga ctcattgagg acaatctgaa gcaggttcat   300
cctctttttc agactgtctt taaaaccttt ctcaaagata aagaaaagat tatcaacgcc   360
cttcaactac actattctaa tgccaaactg gaagcgacca ataatctcat caaacttatc   420
aagcgcaatg cctttggttt tcgaaacttt gaaaacttca aaaaacggat ttttatcgct   480
ttgaacatca aaaaagaaag gacgaaattt gtcctttctc gagct                   525

<210>   3920
<211>   175
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   3920
Met Ser Arg Val His Val Gln Ile Met Asn Gln Phe His Arg Lys Ser 
1               5                   10                  15      

His Glu Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile Gln Gln Asp 
            20                  25                  30          

Ser Arg Lys Leu Ser Asp Lys Arg Phe Tyr Arg Pro Thr Phe Arg Met 
        35                  40                  45              

His Leu Thr Asn Lys Glu Ile Leu Asp Lys Ile Leu Ser Tyr Ser Glu 
    50                  55                  60                  

Asp Leu Lys His His Tyr Gln Ile Tyr Gln Leu Leu Leu Phe His Phe 
65                  70                  75                  80  

Gln Asn Lys Asp Pro Glu Lys Phe Phe Gly Leu Ile Glu Asp Asn Leu 
                85                  90                  95      

Lys Gln Val His Pro Leu Phe Gln Thr Val Phe Lys Thr Phe Leu Lys 
            100                 105                 110         

Asp Lys Glu Lys Ile Ile Asn Ala Leu Gln Leu His Tyr Ser Asn Ala 
        115                 120                 125             

Lys Leu Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys Arg Asn Ala 
    130                 135                 140                 

Phe Gly Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile Phe Ile Ala 
145                 150                 155                 160 

Leu Asn Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser Arg Ala 
                165                 170                 175 

<210>   3921
<211>   924
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3921
atgtctgaaa aattagtaga aatcaaagat ttagaaattt ccttcggtga aggaagtaag   60
aagtttgtcg cggttaaaaa tgctaacttc tttatcaaca agggagaaac tttctcgctt   120
gtaggtgagt ccggtagtgg gaaaacaact attggtcgtg ctatcatcgg tctaaatgat   180
acaagtaatg gagatatcat ttttgatggt caaaagatta atggtaagaa atcgcgtgaa   240
caagctgcgg aattgattcg tcgaatccag atgattttcc aagaccctgc cgcaagtttg   300
aatgaacgtg cgactgttga ttatattatt tctgaaggtc tttacaatca ccgtttattt   360
aaggatgaag aagaacgtaa agagaaagtt caaaatatta tccgtgaagt aggtcttctt   420
gctgagcact tgactcgtta ccctcatgaa ttctcaggcg gtcaacgtca acgtatcggt   480
attgcccgtg ccttggtcat gcaaccagac tttgttattg cagatgagcc aatttcagcc   540
ttggacgttt ctgtacgtgc ccaagtcttg aacttgctca aaaaattcca aaaagagctc   600
ggcctgacct atctcttcat cgcccatgac ttgtcggttg ttcgctttat ttcagatcgt   660
atcgcagtta tttacaaggg tgttattgta gaggttgcag aaacagaaga attgtttaac   720
aatccaattc acccatatac tcaagccttg ctttcagcgg taccaatccc agatccaatc   780
ttggaacgta agaaggtctt gaaggtttac gatccaagtc aacacgacta tgagactgat   840
aagccatcta tggtagaaat ccgtccaggt cactatgttt gggcgaacca agccgaattg   900
gcacgttatc aaaaaggact aaac                                          924

<210>   3922
<211>   308
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligopeptide ABC transporter, ATP-binding protein AmiF (amiF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903745 (e-174)

<400>   3922
Met Ser Glu Lys Leu Val Glu Ile Lys Asp Leu Glu Ile Ser Phe Gly 
1               5                   10                  15      

Glu Gly Ser Lys Lys Phe Val Ala Val Lys Asn Ala Asn Phe Phe Ile 
            20                  25                  30          

Asn Lys Gly Glu Thr Phe Ser Leu Val Gly Glu Ser Gly Ser Gly Lys 
        35                  40                  45              

Thr Thr Ile Gly Arg Ala Ile Ile Gly Leu Asn Asp Thr Ser Asn Gly 
    50                  55                  60                  

Asp Ile Ile Phe Asp Gly Gln Lys Ile Asn Gly Lys Lys Ser Arg Glu 
65                  70                  75                  80  

Gln Ala Ala Glu Leu Ile Arg Arg Ile Gln Met Ile Phe Gln Asp Pro 
                85                  90                  95      

Ala Ala Ser Leu Asn Glu Arg Ala Thr Val Asp Tyr Ile Ile Ser Glu 
            100                 105                 110         

Gly Leu Tyr Asn His Arg Leu Phe Lys Asp Glu Glu Glu Arg Lys Glu 
        115                 120                 125             

Lys Val Gln Asn Ile Ile Arg Glu Val Gly Leu Leu Ala Glu His Leu 
    130                 135                 140                 

Thr Arg Tyr Pro His Glu Phe Ser Gly Gly Gln Arg Gln Arg Ile Gly 
145                 150                 155                 160 

Ile Ala Arg Ala Leu Val Met Gln Pro Asp Phe Val Ile Ala Asp Glu 
                165                 170                 175     

Pro Ile Ser Ala Leu Asp Val Ser Val Arg Ala Gln Val Leu Asn Leu 
            180                 185                 190         

Leu Lys Lys Phe Gln Lys Glu Leu Gly Leu Thr Tyr Leu Phe Ile Ala 
        195                 200                 205             

His Asp Leu Ser Val Val Arg Phe Ile Ser Asp Arg Ile Ala Val Ile 
    210                 215                 220                 

Tyr Lys Gly Val Ile Val Glu Val Ala Glu Thr Glu Glu Leu Phe Asn 
225                 230                 235                 240 

Asn Pro Ile His Pro Tyr Thr Gln Ala Leu Leu Ser Ala Val Pro Ile 
                245                 250                 255     

Pro Asp Pro Ile Leu Glu Arg Lys Lys Val Leu Lys Val Tyr Asp Pro 
            260                 265                 270         

Ser Gln His Asp Tyr Glu Thr Asp Lys Pro Ser Met Val Glu Ile Arg 
        275                 280                 285             

Pro Gly His Tyr Val Trp Ala Asn Gln Ala Glu Leu Ala Arg Tyr Gln 
    290                 295                 300                 

Lys Gly Leu Asn 
305             

<210>   3923
<211>   1065
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3923
atgacaaaag aaaaaaatgt aattttgact gctcgcgata ttgtcgtgga atttgacgtt   60
cgtgacaaag tattgacagc cattcgcggc gtttcccttg aactagtcga aggagaagta   120
ttagccttgg taggtgagtc aggatcaggt aaatctgttt tgacaaagac cttcacaggt   180
atgctcgaag aaaatggtcg tattgcccaa ggtagtattg actaccgtgg tcaggacttg   240
acagctttat cttctcacaa ggattgggaa caaattcgtg gtgctaagat tgcgactatc   300
ttccaggacc caatgactag tttggacccc attaaaacaa ttggtagtca gattacagaa   360
gttattgtaa aacaccaagg aaaaacagct aaagaagcga aagaattggc cattgactac   420
atgaataagg ttggcattcc agacgcagat agacgtttta atgaataccc attccaatat   480
tctggaggaa tgcgtcaacg tatcgttatt gctattgccc ttgcctgccg acctgatgtc   540
ttgatctgtg atgagccaac aactgccttg gatgtaacta ttcaagctca gattattgat   600
ttgctaaaat ctttacaaaa cgagtatcat ttcacaacaa tctttattac ccacgacctt   660
ggtgtggtgg caagtattgc ggataaggta gcggttatgt atgcaggaga aatcgttgag   720
tatggaacgg ttgaggaagt cttctatgac cctcgccatc catatacatg gagtctcttg   780
tctagcttgc ctcagcttgc tgatgataaa ggggatcttt actcaatccc aggaacacct   840
ccgtcacttt atactgacct gaaaggggat gcttttgcct tgcgttctga ctacgcaatg   900
cagattgact tcgaacaaaa agctcctcaa ttctcagtat cagagacaca ttgggctaaa   960
acttggcttc ttcatgagga tgctccgaaa gtagaaaaac cagctgtgat tgcaaatctc   1020
catgataaga tccgtgaaaa aatgggattt gcccatctgg ctgac                   1065

<210>   3924
<211>   355
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligopeptide ABC transporter, ATP-binding protein AmiE (amiE)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903746 (0.E+01)

<400>   3924
Met Thr Lys Glu Lys Asn Val Ile Leu Thr Ala Arg Asp Ile Val Val 
1               5                   10                  15      

Glu Phe Asp Val Arg Asp Lys Val Leu Thr Ala Ile Arg Gly Val Ser 
            20                  25                  30          

Leu Glu Leu Val Glu Gly Glu Val Leu Ala Leu Val Gly Glu Ser Gly 
        35                  40                  45              

Ser Gly Lys Ser Val Leu Thr Lys Thr Phe Thr Gly Met Leu Glu Glu 
    50                  55                  60                  

Asn Gly Arg Ile Ala Gln Gly Ser Ile Asp Tyr Arg Gly Gln Asp Leu 
65                  70                  75                  80  

Thr Ala Leu Ser Ser His Lys Asp Trp Glu Gln Ile Arg Gly Ala Lys 
                85                  90                  95      

Ile Ala Thr Ile Phe Gln Asp Pro Met Thr Ser Leu Asp Pro Ile Lys 
            100                 105                 110         

Thr Ile Gly Ser Gln Ile Thr Glu Val Ile Val Lys His Gln Gly Lys 
        115                 120                 125             

Thr Ala Lys Glu Ala Lys Glu Leu Ala Ile Asp Tyr Met Asn Lys Val 
    130                 135                 140                 

Gly Ile Pro Asp Ala Asp Arg Arg Phe Asn Glu Tyr Pro Phe Gln Tyr 
145                 150                 155                 160 

Ser Gly Gly Met Arg Gln Arg Ile Val Ile Ala Ile Ala Leu Ala Cys 
                165                 170                 175     

Arg Pro Asp Val Leu Ile Cys Asp Glu Pro Thr Thr Ala Leu Asp Val 
            180                 185                 190         

Thr Ile Gln Ala Gln Ile Ile Asp Leu Leu Lys Ser Leu Gln Asn Glu 
        195                 200                 205             

Tyr His Phe Thr Thr Ile Phe Ile Thr His Asp Leu Gly Val Val Ala 
    210                 215                 220                 

Ser Ile Ala Asp Lys Val Ala Val Met Tyr Ala Gly Glu Ile Val Glu 
225                 230                 235                 240 

Tyr Gly Thr Val Glu Glu Val Phe Tyr Asp Pro Arg His Pro Tyr Thr 
                245                 250                 255     

Trp Ser Leu Leu Ser Ser Leu Pro Gln Leu Ala Asp Asp Lys Gly Asp 
            260                 265                 270         

Leu Tyr Ser Ile Pro Gly Thr Pro Pro Ser Leu Tyr Thr Asp Leu Lys 
        275                 280                 285             

Gly Asp Ala Phe Ala Leu Arg Ser Asp Tyr Ala Met Gln Ile Asp Phe 
    290                 295                 300                 

Glu Gln Lys Ala Pro Gln Phe Ser Val Ser Glu Thr His Trp Ala Lys 
305                 310                 315                 320 

Thr Trp Leu Leu His Glu Asp Ala Pro Lys Val Glu Lys Pro Ala Val 
                325                 330                 335     

Ile Ala Asn Leu His Asp Lys Ile Arg Glu Lys Met Gly Phe Ala His 
            340                 345                 350         

Leu Ala Asp 
        355 

<210>   3925
<211>   924
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3925
atgtctacaa tcgataaaga aaaatttcag tttgtaaaac gtgacgattt tgcctctgaa   60
actattgatg cgccagcata ttcttactgg aaatcagtgt ttaaacaatt tatgaagaaa   120
aaatcaactg tagtcatgtt gggaatcttg gtagccatca ttttgataag tttcatctac   180
ccaatgtttt ctaagtttga tttcaatgat gtcagcaagg taaacgactt tagtgttcgt   240
tatatcaagc caaatgcgga gcattggttc ggtactgaca gtaacggtaa atcgctcttt   300
gacggtgtct ggttcggagc tcgtaactcc atcctcattt ctgtgattgc gacagtgatt   360
aacttggtta tcggtgtttt tgtcggtggt atttggggta tttcaaaatc agttgaccgt   420
gtcatgatgg aagtttacaa cgtcatctca aacatcccac ctcttttgat tgttattgtc   480
ttgacttact caatcggagc tggattctgg aatctgattt ttgccatgag cgtaacaaca   540
tggattggta ttgccttcat gatccgtgtg caaatcttgc gctatcgtga cttggaatac   600
aacttggcgt cacgtacttt gggaacacca accttgaaga ttgttgccaa aaatatcatg   660
cctcaattgg tatctgttat tgtgacaacc atgactcaaa tgcttccaag ctttatctca   720
tacgaagcct tcttgtcttt cttcggtctt ggattaccga ttacagtgcc aagtttgggt   780
cgtttgattt cggattattc acaaaacgta acaaccaatg cttacttgtt ctggattcca   840
ttgacaaccc ttgtcttggt atccttgtcc cttttcgtag ttggtcaaaa cttagcggat   900
gctagtgatc cacgtacaca taga                                          924

<210>   3926
<211>   308
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligopeptide ABC transporter, permease protein AmiD (amiD)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903747 (e-175)

<400>   3926
Met Ser Thr Ile Asp Lys Glu Lys Phe Gln Phe Val Lys Arg Asp Asp 
1               5                   10                  15      

Phe Ala Ser Glu Thr Ile Asp Ala Pro Ala Tyr Ser Tyr Trp Lys Ser 
            20                  25                  30          

Val Phe Lys Gln Phe Met Lys Lys Lys Ser Thr Val Val Met Leu Gly 
        35                  40                  45              

Ile Leu Val Ala Ile Ile Leu Ile Ser Phe Ile Tyr Pro Met Phe Ser 
    50                  55                  60                  

Lys Phe Asp Phe Asn Asp Val Ser Lys Val Asn Asp Phe Ser Val Arg 
65                  70                  75                  80  

Tyr Ile Lys Pro Asn Ala Glu His Trp Phe Gly Thr Asp Ser Asn Gly 
                85                  90                  95      

Lys Ser Leu Phe Asp Gly Val Trp Phe Gly Ala Arg Asn Ser Ile Leu 
            100                 105                 110         

Ile Ser Val Ile Ala Thr Val Ile Asn Leu Val Ile Gly Val Phe Val 
        115                 120                 125             

Gly Gly Ile Trp Gly Ile Ser Lys Ser Val Asp Arg Val Met Met Glu 
    130                 135                 140                 

Val Tyr Asn Val Ile Ser Asn Ile Pro Pro Leu Leu Ile Val Ile Val 
145                 150                 155                 160 

Leu Thr Tyr Ser Ile Gly Ala Gly Phe Trp Asn Leu Ile Phe Ala Met 
                165                 170                 175     

Ser Val Thr Thr Trp Ile Gly Ile Ala Phe Met Ile Arg Val Gln Ile 
            180                 185                 190         

Leu Arg Tyr Arg Asp Leu Glu Tyr Asn Leu Ala Ser Arg Thr Leu Gly 
        195                 200                 205             

Thr Pro Thr Leu Lys Ile Val Ala Lys Asn Ile Met Pro Gln Leu Val 
    210                 215                 220                 

Ser Val Ile Val Thr Thr Met Thr Gln Met Leu Pro Ser Phe Ile Ser 
225                 230                 235                 240 

Tyr Glu Ala Phe Leu Ser Phe Phe Gly Leu Gly Leu Pro Ile Thr Val 
                245                 250                 255     

Pro Ser Leu Gly Arg Leu Ile Ser Asp Tyr Ser Gln Asn Val Thr Thr 
            260                 265                 270         

Asn Ala Tyr Leu Phe Trp Ile Pro Leu Thr Thr Leu Val Leu Val Ser 
        275                 280                 285             

Leu Ser Leu Phe Val Val Gly Gln Asn Leu Ala Asp Ala Ser Asp Pro 
    290                 295                 300                 

Arg Thr His Arg 
305             

<210>   3927
<211>   1494
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3927
atgaaaaaat atatttttat gcgtgttttg cggtcattgg tttcgatttt cttagtaacg   60
actttgacct acacgattat ctataccttg gttcctcgaa aattgatttt caagcaggat   120
cctaactata ataaaattgc gacaacggct gataaacgtg ataactatga aaatactgtg   180
tttgagcgta tgggctacat tgagtattac gatactaaag agttgcaaga aaaggcaagt   240
agcatggatt cttctgtaac agtagaagca aatgcgacca ataaagctat ttatgaaaag   300
tacatcaatc aattaggtca tggttggact ttgggagaat ttactgaaag tggtcaattc   360
tatgctactc gtgaaattcc aatttttgaa cgtgtttttc acttctatgc taacttgatt   420
gacattgacc atacaaataa aatccaagac cctgaaaatc cagacttgaa acgctacctt   480
cgttttgaaa atgatccagc tatcggatgg tcattggtcg gttcaggaac taaacataaa   540
tatctcttgt actttaacag tcagttccca tttgttcatc aaaactttgt gaacttgaat   600
ttaggtgact cttacccaac ctatgctaat acaccagttc ttcaggttat tactcaaggt   660
caaggacaaa ccaaaactgc ccaagttcag ttcccaacag gtaagaaaac gtcttctgta   720
aatatttact caagaaccta caagtcacct agtcaggctg actctcgtga agtagctagc   780
tatgggaaag atgatcctta tacagcgact gaaagtaatt accaatatcc atctatgatt   840
gtcagctctg ctattactgg tttgattggt ttggttcttg cctatgctct tgccgtgcca   900
cttggttcag ccatggctcg tttcaagaac acttggattg atagcctctc aacaggggct   960
ttgaccttct tgcttgctct tccaacgatt gccttggttt acatcgttcg attgattgga   1020
tcatctattg cccttccaga ttcattccct atcttgggag ctggagattg gcgttcttac   1080
gttttaccag cagtcatcct tggtttgttg ggtgctcctg gtacagccat ttggattcgt   1140
cgttacatga ttgacttgca atctcaagac tttgttcgtt tcgctcgtgc aaaaggtttg   1200
tctgaaaaag aaatttcaaa caaacacatc tttaaaaatg ccatggttcc gctggtttca   1260
ggaattcctg ctgccattat tggggttatc ggtggtgcaa cccttactga aacagtcttc   1320
gccttcccag gtatgggtaa aatgttgatt gactctgtaa aagcatctaa taactctatg   1380
gtcgttggtc ttgtcttcat ctttacatgt atttctatct tctcacgtct tttgggagat   1440
atttggatga ctattattga cccacgtatt aaattgactg agaaaggagg caaa         1494

<210>   3928
<211>   498
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligopeptide ABC transporer, permease protein AmiC (amiC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903748 (0.E+01)

<400>   3928
Met Lys Lys Tyr Ile Phe Met Arg Val Leu Arg Ser Leu Val Ser Ile 
1               5                   10                  15      

Phe Leu Val Thr Thr Leu Thr Tyr Thr Ile Ile Tyr Thr Leu Val Pro 
            20                  25                  30          

Arg Lys Leu Ile Phe Lys Gln Asp Pro Asn Tyr Asn Lys Ile Ala Thr 
        35                  40                  45              

Thr Ala Asp Lys Arg Asp Asn Tyr Glu Asn Thr Val Phe Glu Arg Met 
    50                  55                  60                  

Gly Tyr Ile Glu Tyr Tyr Asp Thr Lys Glu Leu Gln Glu Lys Ala Ser 
65                  70                  75                  80  

Ser Met Asp Ser Ser Val Thr Val Glu Ala Asn Ala Thr Asn Lys Ala 
                85                  90                  95      

Ile Tyr Glu Lys Tyr Ile Asn Gln Leu Gly His Gly Trp Thr Leu Gly 
            100                 105                 110         

Glu Phe Thr Glu Ser Gly Gln Phe Tyr Ala Thr Arg Glu Ile Pro Ile 
        115                 120                 125             

Phe Glu Arg Val Phe His Phe Tyr Ala Asn Leu Ile Asp Ile Asp His 
    130                 135                 140                 

Thr Asn Lys Ile Gln Asp Pro Glu Asn Pro Asp Leu Lys Arg Tyr Leu 
145                 150                 155                 160 

Arg Phe Glu Asn Asp Pro Ala Ile Gly Trp Ser Leu Val Gly Ser Gly 
                165                 170                 175     

Thr Lys His Lys Tyr Leu Leu Tyr Phe Asn Ser Gln Phe Pro Phe Val 
            180                 185                 190         

His Gln Asn Phe Val Asn Leu Asn Leu Gly Asp Ser Tyr Pro Thr Tyr 
        195                 200                 205             

Ala Asn Thr Pro Val Leu Gln Val Ile Thr Gln Gly Gln Gly Gln Thr 
    210                 215                 220                 

Lys Thr Ala Gln Val Gln Phe Pro Thr Gly Lys Lys Thr Ser Ser Val 
225                 230                 235                 240 

Asn Ile Tyr Ser Arg Thr Tyr Lys Ser Pro Ser Gln Ala Asp Ser Arg 
                245                 250                 255     

Glu Val Ala Ser Tyr Gly Lys Asp Asp Pro Tyr Thr Ala Thr Glu Ser 
            260                 265                 270         

Asn Tyr Gln Tyr Pro Ser Met Ile Val Ser Ser Ala Ile Thr Gly Leu 
        275                 280                 285             

Ile Gly Leu Val Leu Ala Tyr Ala Leu Ala Val Pro Leu Gly Ser Ala 
    290                 295                 300                 

Met Ala Arg Phe Lys Asn Thr Trp Ile Asp Ser Leu Ser Thr Gly Ala 
305                 310                 315                 320 

Leu Thr Phe Leu Leu Ala Leu Pro Thr Ile Ala Leu Val Tyr Ile Val 
                325                 330                 335     

Arg Leu Ile Gly Ser Ser Ile Ala Leu Pro Asp Ser Phe Pro Ile Leu 
            340                 345                 350         

Gly Ala Gly Asp Trp Arg Ser Tyr Val Leu Pro Ala Val Ile Leu Gly 
        355                 360                 365             

Leu Leu Gly Ala Pro Gly Thr Ala Ile Trp Ile Arg Arg Tyr Met Ile 
    370                 375                 380                 

Asp Leu Gln Ser Gln Asp Phe Val Arg Phe Ala Arg Ala Lys Gly Leu 
385                 390                 395                 400 

Ser Glu Lys Glu Ile Ser Asn Lys His Ile Phe Lys Asn Ala Met Val 
                405                 410                 415     

Pro Leu Val Ser Gly Ile Pro Ala Ala Ile Ile Gly Val Ile Gly Gly 
            420                 425                 430         

Ala Thr Leu Thr Glu Thr Val Phe Ala Phe Pro Gly Met Gly Lys Met 
        435                 440                 445             

Leu Ile Asp Ser Val Lys Ala Ser Asn Asn Ser Met Val Val Gly Leu 
    450                 455                 460                 

Val Phe Ile Phe Thr Cys Ile Ser Ile Phe Ser Arg Leu Leu Gly Asp 
465                 470                 475                 480 

Ile Trp Met Thr Ile Ile Asp Pro Arg Ile Lys Leu Thr Glu Lys Gly 
                485                 490                 495     

Gly Lys 
        

<210>   3929
<211>   1977
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3929
atgaaaaaaa atcgtgtatt tgctacagca ggtcttgttt tattagcagc aggtgtactt   60
gcagcatgca gttcttcaaa atcatctgat tcatcagccc ctaaagctta tggctatgtt   120
tatacagcag acccagaaac cttggactac ctgatttcaa gtaaaaatag tacaacagta   180
gtgacttcaa atgggattga tggtttattc actaacgata attacggtaa tcttgctcct   240
gcagttgcag aggattggga agtctctaag gatggtttga cctacactta taagattcgt   300
aaaggggtta aatggtttac ctctgatgga gaagaatatg cagaggtgac ggctaaagat   360
ttcgtgaacg gtttaaaaca cgcagcagat aaaaaatcag aagctatgta tttagctgaa   420
aattcggtta aaggcttggc agattatcta tcaggaactt caacagattt ttcaacagtt   480
ggtgtcaagg cggttgatga ttatacgtta caatacactt tgaaccagcc tgaaccgttc   540
tggaactcta agttgaccta ttctattttc tggcctctga atgaagaatt cgaaacatca   600
aaaggaagcg attttgctaa accaacagat ccgacatcct tgctttataa tggtccattc   660
ttgttgaaag ggttgactgc aaaatcttct gtagagtttg taaaaaatga gcaatattgg   720
gataaagaaa atgtccacct agatactatc aatctagctt actatgatgg atcagatcag   780
gagtcgctag agcgtaactt cactagtgga gcttatagtt atgcccgtct ttaccctacc   840
agctccaact attctaaggt tgcagaagaa tacaaggaca atatctatta cacacaatca   900
ggctctggga ttgctggtct gggtgtgaat attgatcgcc aaagttacaa ctatacttct   960
aaaactacag attcagagaa agtagctact aagaaggcat tgcttaacaa agatttccgt   1020
caagccttga attttgctct tgatcgctca gcttactcag ctcaaatcaa tggtaaagat   1080
ggagcagctt tagcagttcg taatttattt gtaaaaccag actttgtttc agctggtgag   1140
aagacctttg gtgatttagt cgctgctcaa cttcctgctt atggtgatga gtggaaaggt   1200
gtgaatttag ctgatgggca ggatggttta ttcaatgctg acaaggccaa ggcagagttt   1260
gcgaaagcta agaaagcttt agaagcagac ggcgttcagt ttcctattca tctggacgtt   1320
ccagtagacc aagcatcaaa aaactacata tctcgtattc agtcctttaa acaatctgta   1380
gaaacagttc ttggtgttga aaatgtcgtt gttgatattc aacaaatgac aagtgatgaa   1440
ttccttaata ttacttacta tgctgccaat gcttcatctg aggattggga tgtatcagga   1500
ggagtttcat gggggccaga ctatcaagac ccatctactt acctggatat tttaaaaaca   1560
actagcagtg aaactacaaa aacatattta ggatttgata atccaaatag cccttcagta   1620
gttcaagttg gtttgaaaga atacgataaa ttagttgatg aagctgccag agagacaagc   1680
gacttgaatg tccgttatga aaaatatgca gcggctcaag catggttgac agatagttca   1740
ctctttattc ctgctatggc ttcttctggt gcagcaccag tgctttcacg aattgttcca   1800
tttactggag cttctgcgca aacaggctct aaggggtcag atgtttactt caaatatttg   1860
aaatcacaag ataaagtggt gactaaggaa gagtatgaaa aagctcgtga aaaatggttg   1920
aaagaaaaag ctgaatcaaa tgagaaagct caaaaagaat tggcaagtca tgtgaag      1977

<210>   3930
<211>   659
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oligopeptide ABC transporter, oligopeptide-binding protein AmiA (amiA)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903749 (0.E+01)

<400>   3930
Met Lys Lys Asn Arg Val Phe Ala Thr Ala Gly Leu Val Leu Leu Ala 
1               5                   10                  15      

Ala Gly Val Leu Ala Ala Cys Ser Ser Ser Lys Ser Ser Asp Ser Ser 
            20                  25                  30          

Ala Pro Lys Ala Tyr Gly Tyr Val Tyr Thr Ala Asp Pro Glu Thr Leu 
        35                  40                  45              

Asp Tyr Leu Ile Ser Ser Lys Asn Ser Thr Thr Val Val Thr Ser Asn 
    50                  55                  60                  

Gly Ile Asp Gly Leu Phe Thr Asn Asp Asn Tyr Gly Asn Leu Ala Pro 
65                  70                  75                  80  

Ala Val Ala Glu Asp Trp Glu Val Ser Lys Asp Gly Leu Thr Tyr Thr 
                85                  90                  95      

Tyr Lys Ile Arg Lys Gly Val Lys Trp Phe Thr Ser Asp Gly Glu Glu 
            100                 105                 110         

Tyr Ala Glu Val Thr Ala Lys Asp Phe Val Asn Gly Leu Lys His Ala 
        115                 120                 125             

Ala Asp Lys Lys Ser Glu Ala Met Tyr Leu Ala Glu Asn Ser Val Lys 
    130                 135                 140                 

Gly Leu Ala Asp Tyr Leu Ser Gly Thr Ser Thr Asp Phe Ser Thr Val 
145                 150                 155                 160 

Gly Val Lys Ala Val Asp Asp Tyr Thr Leu Gln Tyr Thr Leu Asn Gln 
                165                 170                 175     

Pro Glu Pro Phe Trp Asn Ser Lys Leu Thr Tyr Ser Ile Phe Trp Pro 
            180                 185                 190         

Leu Asn Glu Glu Phe Glu Thr Ser Lys Gly Ser Asp Phe Ala Lys Pro 
        195                 200                 205             

Thr Asp Pro Thr Ser Leu Leu Tyr Asn Gly Pro Phe Leu Leu Lys Gly 
    210                 215                 220                 

Leu Thr Ala Lys Ser Ser Val Glu Phe Val Lys Asn Glu Gln Tyr Trp 
225                 230                 235                 240 

Asp Lys Glu Asn Val His Leu Asp Thr Ile Asn Leu Ala Tyr Tyr Asp 
                245                 250                 255     

Gly Ser Asp Gln Glu Ser Leu Glu Arg Asn Phe Thr Ser Gly Ala Tyr 
            260                 265                 270         

Ser Tyr Ala Arg Leu Tyr Pro Thr Ser Ser Asn Tyr Ser Lys Val Ala 
        275                 280                 285             

Glu Glu Tyr Lys Asp Asn Ile Tyr Tyr Thr Gln Ser Gly Ser Gly Ile 
    290                 295                 300                 

Ala Gly Leu Gly Val Asn Ile Asp Arg Gln Ser Tyr Asn Tyr Thr Ser 
305                 310                 315                 320 

Lys Thr Thr Asp Ser Glu Lys Val Ala Thr Lys Lys Ala Leu Leu Asn 
                325                 330                 335     

Lys Asp Phe Arg Gln Ala Leu Asn Phe Ala Leu Asp Arg Ser Ala Tyr 
            340                 345                 350         

Ser Ala Gln Ile Asn Gly Lys Asp Gly Ala Ala Leu Ala Val Arg Asn 
        355                 360                 365             

Leu Phe Val Lys Pro Asp Phe Val Ser Ala Gly Glu Lys Thr Phe Gly 
    370                 375                 380                 

Asp Leu Val Ala Ala Gln Leu Pro Ala Tyr Gly Asp Glu Trp Lys Gly 
385                 390                 395                 400 

Val Asn Leu Ala Asp Gly Gln Asp Gly Leu Phe Asn Ala Asp Lys Ala 
                405                 410                 415     

Lys Ala Glu Phe Ala Lys Ala Lys Lys Ala Leu Glu Ala Asp Gly Val 
            420                 425                 430         

Gln Phe Pro Ile His Leu Asp Val Pro Val Asp Gln Ala Ser Lys Asn 
        435                 440                 445             

Tyr Ile Ser Arg Ile Gln Ser Phe Lys Gln Ser Val Glu Thr Val Leu 
    450                 455                 460                 

Gly Val Glu Asn Val Val Val Asp Ile Gln Gln Met Thr Ser Asp Glu 
465                 470                 475                 480 

Phe Leu Asn Ile Thr Tyr Tyr Ala Ala Asn Ala Ser Ser Glu Asp Trp 
                485                 490                 495     

Asp Val Ser Gly Gly Val Ser Trp Gly Pro Asp Tyr Gln Asp Pro Ser 
            500                 505                 510         

Thr Tyr Leu Asp Ile Leu Lys Thr Thr Ser Ser Glu Thr Thr Lys Thr 
        515                 520                 525             

Tyr Leu Gly Phe Asp Asn Pro Asn Ser Pro Ser Val Val Gln Val Gly 
    530                 535                 540                 

Leu Lys Glu Tyr Asp Lys Leu Val Asp Glu Ala Ala Arg Glu Thr Ser 
545                 550                 555                 560 

Asp Leu Asn Val Arg Tyr Glu Lys Tyr Ala Ala Ala Gln Ala Trp Leu 
                565                 570                 575     

Thr Asp Ser Ser Leu Phe Ile Pro Ala Met Ala Ser Ser Gly Ala Ala 
            580                 585                 590         

Pro Val Leu Ser Arg Ile Val Pro Phe Thr Gly Ala Ser Ala Gln Thr 
        595                 600                 605             

Gly Ser Lys Gly Ser Asp Val Tyr Phe Lys Tyr Leu Lys Ser Gln Asp 
    610                 615                 620                 

Lys Val Val Thr Lys Glu Glu Tyr Glu Lys Ala Arg Glu Lys Trp Leu 
625                 630                 635                 640 

Lys Glu Lys Ala Glu Ser Asn Glu Lys Ala Gln Lys Glu Leu Ala Ser 
                645                 650                 655     

His Val Lys 
            

<210>   3931
<211>   165
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3931
atgattcaaa ttgtcgttcg aagtgtcaaa gactacagtg aaaataggaa atttgacgca   60
gaaactttgg agtttaggaa gacatacagt aaaatgaaat acggacggaa caatgtgatt   120
ttggaattca aattaaatta taacaatatt gtagaagtat cattc                   165

<210>   3932
<211>   55
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3932
Met Ile Gln Ile Val Val Arg Ser Val Lys Asp Tyr Ser Glu Asn Arg 
1               5                   10                  15      

Lys Phe Asp Ala Glu Thr Leu Glu Phe Arg Lys Thr Tyr Ser Lys Met 
            20                  25                  30          

Lys Tyr Gly Arg Asn Asn Val Ile Leu Glu Phe Lys Leu Asn Tyr Asn 
        35                  40                  45              

Asn Ile Val Glu Val Ser Phe 
    50                  55  

<210>   3933
<211>   1191
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3933
ttgaaatcaa taggctttat tgaaaagctg aaggggttgt ctagtaaaga gctgatttta   60
ttgggaatta tcctgagtat ctttttaccc ttttatcttt ttgtagttgt actctgttta   120
tatattatca gtttgatttt tacaggagac atgaaaagta ttcttcagaa aatgggggag   180
catccgatgc tgcttctttt tcttagctat agtactgtta tatccattct tgcacaaaat   240
tggatgggtc ttgtggcttc agtaggaatg tttctattta ctattttctt tttgcactat   300
cagtcgattt tatcccataa attctttcga ttgattttgc agtttgtctt gtttggtagt   360
gtcttgtcag ctgcttttgc cagtttagaa catttccaaa ttgtgaagaa atttaactat   420
gcttttcttt cacccaatat gcaggtgtgg catcagaacc gggcagaagt gaccttcttt   480
aatcctaatt attatggaat tatttgttgt ttctgtatta tgattgcttt ctatctgttt   540
acaacgacca agttgaattg gttgaaagta ttctgtgtga ttgcaggctt tgttaatctc   600
tttggtttga actttactca aaatcgaact gcctttcctg ctattatcgc tggagcaatt   660
atctatctct ttacgactat taaaaactgg aaggcctttt ggcttagtat tggggtcttc   720
gcgattggtt tgagtttcct cttttctagt gatttgggag ttcgaatggg tactttagac   780
tcttctatgg aagaacgcat ttctatctgg gatgctggga tggccttgtt taagcaaaat   840
cctttttggg gtgaagggcc attgacctat atgaactctt atcctcggat acatgctcct   900
tatcatgaac atgcccacag tctttatatt gatacgattc tgagttacgg aattgtgggg   960
actattttat tagttttgtc ttctgttgct cctgttcgct tgatgatgga tatgagtcag   1020
gagtcgggga aacgtccgat tatcggcctt tatctatctt tccttacagt ggttgctgtg   1080
cacggaattt ttgacttggc tctcttctgg attcagtcag gctttatttt cttgctagtt   1140
atgtgcagta ttccattgga gcatcgaatg ttggtatcgg acatgacgga t            1191

<210>   3934
<211>   397
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903750 (0.E+01)

<400>   3934
Met Lys Ser Ile Gly Phe Ile Glu Lys Leu Lys Gly Leu Ser Ser Lys 
1               5                   10                  15      

Glu Leu Ile Leu Leu Gly Ile Ile Leu Ser Ile Phe Leu Pro Phe Tyr 
            20                  25                  30          

Leu Phe Val Val Val Leu Cys Leu Tyr Ile Ile Ser Leu Ile Phe Thr 
        35                  40                  45              

Gly Asp Met Lys Ser Ile Leu Gln Lys Met Gly Glu His Pro Met Leu 
    50                  55                  60                  

Leu Leu Phe Leu Ser Tyr Ser Thr Val Ile Ser Ile Leu Ala Gln Asn 
65                  70                  75                  80  

Trp Met Gly Leu Val Ala Ser Val Gly Met Phe Leu Phe Thr Ile Phe 
                85                  90                  95      

Phe Leu His Tyr Gln Ser Ile Leu Ser His Lys Phe Phe Arg Leu Ile 
            100                 105                 110         

Leu Gln Phe Val Leu Phe Gly Ser Val Leu Ser Ala Ala Phe Ala Ser 
        115                 120                 125             

Leu Glu His Phe Gln Ile Val Lys Lys Phe Asn Tyr Ala Phe Leu Ser 
    130                 135                 140                 

Pro Asn Met Gln Val Trp His Gln Asn Arg Ala Glu Val Thr Phe Phe 
145                 150                 155                 160 

Asn Pro Asn Tyr Tyr Gly Ile Ile Cys Cys Phe Cys Ile Met Ile Ala 
                165                 170                 175     

Phe Tyr Leu Phe Thr Thr Thr Lys Leu Asn Trp Leu Lys Val Phe Cys 
            180                 185                 190         

Val Ile Ala Gly Phe Val Asn Leu Phe Gly Leu Asn Phe Thr Gln Asn 
        195                 200                 205             

Arg Thr Ala Phe Pro Ala Ile Ile Ala Gly Ala Ile Ile Tyr Leu Phe 
    210                 215                 220                 

Thr Thr Ile Lys Asn Trp Lys Ala Phe Trp Leu Ser Ile Gly Val Phe 
225                 230                 235                 240 

Ala Ile Gly Leu Ser Phe Leu Phe Ser Ser Asp Leu Gly Val Arg Met 
                245                 250                 255     

Gly Thr Leu Asp Ser Ser Met Glu Glu Arg Ile Ser Ile Trp Asp Ala 
            260                 265                 270         

Gly Met Ala Leu Phe Lys Gln Asn Pro Phe Trp Gly Glu Gly Pro Leu 
        275                 280                 285             

Thr Tyr Met Asn Ser Tyr Pro Arg Ile His Ala Pro Tyr His Glu His 
    290                 295                 300                 

Ala His Ser Leu Tyr Ile Asp Thr Ile Leu Ser Tyr Gly Ile Val Gly 
305                 310                 315                 320 

Thr Ile Leu Leu Val Leu Ser Ser Val Ala Pro Val Arg Leu Met Met 
                325                 330                 335     

Asp Met Ser Gln Glu Ser Gly Lys Arg Pro Ile Ile Gly Leu Tyr Leu 
            340                 345                 350         

Ser Phe Leu Thr Val Val Ala Val His Gly Ile Phe Asp Leu Ala Leu 
        355                 360                 365             

Phe Trp Ile Gln Ser Gly Phe Ile Phe Leu Leu Val Met Cys Ser Ile 
    370                 375                 380                 

Pro Leu Glu His Arg Met Leu Val Ser Asp Met Thr Asp 
385                 390                 395         

<210>   3935
<211>   1470
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3935
ttggcttcaa ttagaaaaag gagagtaatg atgccaattc aaaataaaac catgttgatt   60
acctattctg atagccttgg aaataatctt aaagacttat atgataattt ggaagagcat   120
tttggagatg ctattggagg agttcacctt ttaccatttt tcccatcaac agttgatcgt   180
ggatttgcgc cagttgacta cgacgaagtg gactcagctt ttggtgattg ggaggatgtg   240
aagcgtttag gtgagaaata ttatcttatg tttgatttta tgattaatca tatttctcgt   300
caatccaagt attataagga ctatcaagaa aaacatgaag ccagtgaatt taaagctctc   360
tttttaaact gggataagtt ttggccagaa aaccgtccga cacagtctga tgtagattta   420
atttacaagc gtaaggatcg tgcaccaaag caagagattg tgtttgaaga tggttcagtg   480
gaacatttgt ggaatacctt tggtgaggag cagattgatc ttgatgtgac caaagaagta   540
actatggaat ttatccgtaa gaccattcag cacttggcaa gtaatgggtg tgatttgatt   600
cgtctagatg cctttgctta tgcagtgaag aaattggata ctaatgattt ctttgtggaa   660
ccagatattt gggatttatt ggacaaagtt cgagatatcg ctgctgagta tgggacagag   720
cttttacctg agattcatga acactattcg attcagttta aaatagcaga ccatgattac   780
tatgtttatg attttgctct tccaatggtg acactttata ctctttacag ttccagaaca   840
gagcgtttgg ctaagtggtt aaagatgagc ccgatgaagc aatttacgac gctagatacc   900
catgatggga ttggagtagt agatgtcaag gatatcctga ccgatgagga gattgactat   960
gcttcaaatg aactctataa ggttggagcc aatgtcaaac gtaagtactc tagtgccgag   1020
tataacaact tagatatcta ccaaatcaat tcaacctact attcagcgct tggagatgat   1080
gatgtcaagt attttctcgc tcgtctaatt caagcttttg ccccaggtat tcctcagatt   1140
tactatgtgg gtctattagc aggcaagaat gacttgaaat tattagaaga aactaaagaa   1200
ggtcgaaata ttaatcgtca ttactatagc aacgaggaaa tagcaaaaga agtgcaacga   1260
cctgttgtga aggcccttct caatctattt tctttccgta accgttcaga agcctttgat   1320
ctagaaggga ctactgagat agagacacca acagctcaca gcattgtaat caaacgtcaa   1380
aataaagata agtccgtaac agcagtagta gaaattgatt tgcaaaatca gacttatcgg   1440
gtaattgaga atggagttga agtatcattt                                    1470

<210>   3936
<211>   490
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sucrose phosphorylase (gftA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903751 (0.E+01)

<400>   3936
Met Ala Ser Ile Arg Lys Arg Arg Val Met Met Pro Ile Gln Asn Lys 
1               5                   10                  15      

Thr Met Leu Ile Thr Tyr Ser Asp Ser Leu Gly Asn Asn Leu Lys Asp 
            20                  25                  30          

Leu Tyr Asp Asn Leu Glu Glu His Phe Gly Asp Ala Ile Gly Gly Val 
        35                  40                  45              

His Leu Leu Pro Phe Phe Pro Ser Thr Val Asp Arg Gly Phe Ala Pro 
    50                  55                  60                  

Val Asp Tyr Asp Glu Val Asp Ser Ala Phe Gly Asp Trp Glu Asp Val 
65                  70                  75                  80  

Lys Arg Leu Gly Glu Lys Tyr Tyr Leu Met Phe Asp Phe Met Ile Asn 
                85                  90                  95      

His Ile Ser Arg Gln Ser Lys Tyr Tyr Lys Asp Tyr Gln Glu Lys His 
            100                 105                 110         

Glu Ala Ser Glu Phe Lys Ala Leu Phe Leu Asn Trp Asp Lys Phe Trp 
        115                 120                 125             

Pro Glu Asn Arg Pro Thr Gln Ser Asp Val Asp Leu Ile Tyr Lys Arg 
    130                 135                 140                 

Lys Asp Arg Ala Pro Lys Gln Glu Ile Val Phe Glu Asp Gly Ser Val 
145                 150                 155                 160 

Glu His Leu Trp Asn Thr Phe Gly Glu Glu Gln Ile Asp Leu Asp Val 
                165                 170                 175     

Thr Lys Glu Val Thr Met Glu Phe Ile Arg Lys Thr Ile Gln His Leu 
            180                 185                 190         

Ala Ser Asn Gly Cys Asp Leu Ile Arg Leu Asp Ala Phe Ala Tyr Ala 
        195                 200                 205             

Val Lys Lys Leu Asp Thr Asn Asp Phe Phe Val Glu Pro Asp Ile Trp 
    210                 215                 220                 

Asp Leu Leu Asp Lys Val Arg Asp Ile Ala Ala Glu Tyr Gly Thr Glu 
225                 230                 235                 240 

Leu Leu Pro Glu Ile His Glu His Tyr Ser Ile Gln Phe Lys Ile Ala 
                245                 250                 255     

Asp His Asp Tyr Tyr Val Tyr Asp Phe Ala Leu Pro Met Val Thr Leu 
            260                 265                 270         

Tyr Thr Leu Tyr Ser Ser Arg Thr Glu Arg Leu Ala Lys Trp Leu Lys 
        275                 280                 285             

Met Ser Pro Met Lys Gln Phe Thr Thr Leu Asp Thr His Asp Gly Ile 
    290                 295                 300                 

Gly Val Val Asp Val Lys Asp Ile Leu Thr Asp Glu Glu Ile Asp Tyr 
305                 310                 315                 320 

Ala Ser Asn Glu Leu Tyr Lys Val Gly Ala Asn Val Lys Arg Lys Tyr 
                325                 330                 335     


Ser Ser Ala Glu Tyr Asn Asn Leu Asp Ile Tyr Gln Ile Asn Ser Thr 
            340                 345                 350         

Tyr Tyr Ser Ala Leu Gly Asp Asp Asp Val Lys Tyr Phe Leu Ala Arg 
        355                 360                 365             

Leu Ile Gln Ala Phe Ala Pro Gly Ile Pro Gln Ile Tyr Tyr Val Gly 
    370                 375                 380                 

Leu Leu Ala Gly Lys Asn Asp Leu Lys Leu Leu Glu Glu Thr Lys Glu 
385                 390                 395                 400 

Gly Arg Asn Ile Asn Arg His Tyr Tyr Ser Asn Glu Glu Ile Ala Lys 
                405                 410                 415     

Glu Val Gln Arg Pro Val Val Lys Ala Leu Leu Asn Leu Phe Ser Phe 
            420                 425                 430         

Arg Asn Arg Ser Glu Ala Phe Asp Leu Glu Gly Thr Thr Glu Ile Glu 
        435                 440                 445             

Thr Pro Thr Ala His Ser Ile Val Ile Lys Arg Gln Asn Lys Asp Lys 
    450                 455                 460                 

Ser Val Thr Ala Val Val Glu Ile Asp Leu Gln Asn Gln Thr Tyr Arg 
465                 470                 475                 480 

Val Ile Glu Asn Gly Val Glu Val Ser Phe 
                485                 490 

<210>   3937
<211>   165
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3937
atgaaaatca aagagcaaac taggaagcta gccgcaggtt gctcaaaaca ctgttttgag   60
gttgtggatg aaactgacga agtcagtaac catacctacg gcaaggtgaa gctgacgtgg   120
tttgaagaga ttttcgaaga gtataagaag agctcatgga atcta                   165

<210>   3938
<211>   55
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3938
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Asn His Thr 
            20                  25                  30          

Tyr Gly Lys Val Lys Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr 
        35                  40                  45              

Lys Lys Ser Ser Trp Asn Leu 
    50                  55  

<210>   3939
<211>   855
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3939
ttgaaattta agaggagaag catgatgaaa caagatgaaa gaaaagccct gattggcaaa   60
tacattctat tgattctagg atcggttctg attttagtgc cgctccttgc taccctcttt   120
agttccttca aacccactaa ggatattgta gataatttct ttggctttcc aaccaacttc   180
acatgggaca actttagccg tctcttagct gatgggattg gaggctatta ttggaactct   240
gtcgtcatca ctgtcttgtc tttacttgca gtaatgatct ttatccctat ggcagcctac   300
tccatcgctc gcaatatgag taaaagaaaa gcctttacca tcatgtatac cctcttaatc   360
ctcggaatct tcgtaccttt ccaagtcatc atgattccga ttacggttat gatgagtaaa   420
ctcggtttgg ctaatacctt tggtttgatc ttgctctact tgacctatgc gattccacag   480
accctctttc tctatgttgg ctatatcaaa atctcgattc cagaaagtct ggatgaagca   540
gcagagatcg atggggctaa tcaatttaca acctatttcc gcatcatctt cccaatgatg   600
aaaccgatgc atgcgacaac catgatcatc aatgcccttt ggttctggaa tgacttcatg   660
ttgccactcc ttgtcttgaa ccgggattcc aaaatgtgga ctctgccttt gttccaatac   720
aactacgcag gccaatattt caacgactac ggaccaagct ttgcctctta cgtggtcggc   780
attatcagta tcaccattgt ctatctcttc ttccaacgcc atatcatttc aggaatgagc   840
aacggggcag tgaag                                                    855

<210>   3940
<211>   285
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, permease protein (msmG)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903752 (e-159)

<400>   3940
Met Lys Phe Lys Arg Arg Ser Met Met Lys Gln Asp Glu Arg Lys Ala 
1               5                   10                  15      

Leu Ile Gly Lys Tyr Ile Leu Leu Ile Leu Gly Ser Val Leu Ile Leu 
            20                  25                  30          

Val Pro Leu Leu Ala Thr Leu Phe Ser Ser Phe Lys Pro Thr Lys Asp 
        35                  40                  45              

Ile Val Asp Asn Phe Phe Gly Phe Pro Thr Asn Phe Thr Trp Asp Asn 
    50                  55                  60                  

Phe Ser Arg Leu Leu Ala Asp Gly Ile Gly Gly Tyr Tyr Trp Asn Ser 
65                  70                  75                  80  

Val Val Ile Thr Val Leu Ser Leu Leu Ala Val Met Ile Phe Ile Pro 
                85                  90                  95      

Met Ala Ala Tyr Ser Ile Ala Arg Asn Met Ser Lys Arg Lys Ala Phe 
            100                 105                 110         

Thr Ile Met Tyr Thr Leu Leu Ile Leu Gly Ile Phe Val Pro Phe Gln 
        115                 120                 125             

Val Ile Met Ile Pro Ile Thr Val Met Met Ser Lys Leu Gly Leu Ala 
    130                 135                 140                 

Asn Thr Phe Gly Leu Ile Leu Leu Tyr Leu Thr Tyr Ala Ile Pro Gln 
145                 150                 155                 160 

Thr Leu Phe Leu Tyr Val Gly Tyr Ile Lys Ile Ser Ile Pro Glu Ser 
                165                 170                 175     

Leu Asp Glu Ala Ala Glu Ile Asp Gly Ala Asn Gln Phe Thr Thr Tyr 
            180                 185                 190         

Phe Arg Ile Ile Phe Pro Met Met Lys Pro Met His Ala Thr Thr Met 
        195                 200                 205             

Ile Ile Asn Ala Leu Trp Phe Trp Asn Asp Phe Met Leu Pro Leu Leu 
    210                 215                 220                 

Val Leu Asn Arg Asp Ser Lys Met Trp Thr Leu Pro Leu Phe Gln Tyr 
225                 230                 235                 240 

Asn Tyr Ala Gly Gln Tyr Phe Asn Asp Tyr Gly Pro Ser Phe Ala Ser 
                245                 250                 255     

Tyr Val Val Gly Ile Ile Ser Ile Thr Ile Val Tyr Leu Phe Phe Gln 
            260                 265                 270         

Arg His Ile Ile Ser Gly Met Ser Asn Gly Ala Val Lys 
        275                 280                 285 

<210>   3941
<211>   888
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3941
atgtggatta ggagtagaga gactatgaaa aaagtattac aaaaatattg ggcatgggct   60
tttgtggtca tccccctctt gttacaagca attttcttct atgtgccgat gtttcaagga   120
gccttttaca gttttaccaa ctggacagga ttgacttata actacaaatt tgttggctta   180
aacaacttta agctcctctt catggatcca aaattcatga atgcgattgg ctttaccgca   240
atcattgcga ttgccatggt ggttggtgag attgcactcg ggatcttcat tgcgcgtgtc   300
ttgaattcta aaatcaaagg ccaaaccttc ttccgtgctt ggttcttctt cccagctgtt   360
ttatctggtt tgacagtggc tttgatcttc aagcaagtct tcaactacgg tcttccagcg   420
attggaaatg cccttcatat tgaatttttc caaaccagtc ttttagggac taagtgggga   480
gcaatctttg cggctgtctt tgtccttctt tggcaagggg tggctatgcc catcatcatc   540
ttcctagctg gtttgcaatc tattccaact gagattacag aggcagcaag gattgatggt   600
gcgactagca agcaagtttt ctggaacatt gaattgcctt acttgctacc aagtgtctct   660
atggtcttta tcctagccct aaaaggtggg ctgactgcct ttgaccaagt ctttgccatg   720
accggtggtg gtccaaacaa tgccacaacc tcacttgggc tcttggttta taactatgcc   780
tttaaaaaca accaattcgg ttatgccaat gccattgccg taatcttgtt cttcttaatt   840
gtagtgattt cgatcatcca attgagagta tctaagaaat ttgaaatt                888

<210>   3942
<211>   296
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, permease protein (msmF)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903753 (e-167)

<400>   3942
Met Trp Ile Arg Ser Arg Glu Thr Met Lys Lys Val Leu Gln Lys Tyr 
1               5                   10                  15      

Trp Ala Trp Ala Phe Val Val Ile Pro Leu Leu Leu Gln Ala Ile Phe 
            20                  25                  30          

Phe Tyr Val Pro Met Phe Gln Gly Ala Phe Tyr Ser Phe Thr Asn Trp 
        35                  40                  45              

Thr Gly Leu Thr Tyr Asn Tyr Lys Phe Val Gly Leu Asn Asn Phe Lys 
    50                  55                  60                  

Leu Leu Phe Met Asp Pro Lys Phe Met Asn Ala Ile Gly Phe Thr Ala 
65                  70                  75                  80  

Ile Ile Ala Ile Ala Met Val Val Gly Glu Ile Ala Leu Gly Ile Phe 
                85                  90                  95      

Ile Ala Arg Val Leu Asn Ser Lys Ile Lys Gly Gln Thr Phe Phe Arg 
            100                 105                 110         

Ala Trp Phe Phe Phe Pro Ala Val Leu Ser Gly Leu Thr Val Ala Leu 
        115                 120                 125             

Ile Phe Lys Gln Val Phe Asn Tyr Gly Leu Pro Ala Ile Gly Asn Ala 
    130                 135                 140                 

Leu His Ile Glu Phe Phe Gln Thr Ser Leu Leu Gly Thr Lys Trp Gly 
145                 150                 155                 160 

Ala Ile Phe Ala Ala Val Phe Val Leu Leu Trp Gln Gly Val Ala Met 
                165                 170                 175     

Pro Ile Ile Ile Phe Leu Ala Gly Leu Gln Ser Ile Pro Thr Glu Ile 
            180                 185                 190         

Thr Glu Ala Ala Arg Ile Asp Gly Ala Thr Ser Lys Gln Val Phe Trp 
        195                 200                 205             

Asn Ile Glu Leu Pro Tyr Leu Leu Pro Ser Val Ser Met Val Phe Ile 
    210                 215                 220                 

Leu Ala Leu Lys Gly Gly Leu Thr Ala Phe Asp Gln Val Phe Ala Met 
225                 230                 235                 240 

Thr Gly Gly Gly Pro Asn Asn Ala Thr Thr Ser Leu Gly Leu Leu Val 
                245                 250                 255     

Tyr Asn Tyr Ala Phe Lys Asn Asn Gln Phe Gly Tyr Ala Asn Ala Ile 
            260                 265                 270         

Ala Val Ile Leu Phe Phe Leu Ile Val Val Ile Ser Ile Ile Gln Leu 
        275                 280                 285             

Arg Val Ser Lys Lys Phe Glu Ile 
    290                 295     

<210>   3943
<211>   1257
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3943
atggaatggt ataaaaaaat cggacttctt gcaactacag gtttagcttt gtttgggctc   60
ggcgcttgct ccaactatgg taaatctgcg gatggcacag tgaccatcga gtatttcaac   120
cagaaaaaag aaatgaccaa aaccttggaa gaaatcactc gtgattttga gaaggaaaac   180
cctaagatca aggtcaaagt cgtcaatgta ccaaatgctg gtgaagtatt gaagacacgc   240
gttctcgcag gagatgtgcc tgatgtggtc aatatttacc cacagtccat cgaactgcaa   300
gaatgggcaa aagcaggtgt ttttgaagat ttgagcaaca aagactacct gaaacgcgtg   360
aaaaatggct acgctgaaaa atatgctgta aacgaaaaag tttacaacgt tccttttaca   420
gctaatgctt atggaattta ctacaacaaa gataaattcg aagaactggg cttgaaggtt   480
cctgaaacct gggatgaatt tgaacagtta gtcaaagata tcgttgctaa aggacaaaca   540
ccatttggaa ttgcaggtgc agatgcttgg acactcaatg gttacaatca attagccttt   600
gcgacagcaa caggtggagg aaaagaagca aatcaatacc ttcgttattc tcaaccaaat   660
gccattaaat tgtcggatcc gattatgaaa gatgatatca aggtcatgga catccttcgc   720
atcaatggat ctaagcaaaa gaactgggaa ggtgctggct ataccgatgt tatcggagcc   780
ttcgcacgtg gggatgtcct catgacacca aatgggtctt gggcgatcac agcgattaat   840
gaacaaaaac cgaactttaa gattgggacc ttcatgattc caggaaaaga aaaaggacaa   900
agcttaaccg ttggtgcggg agacttggca tggtctatct cagccaccac caaacatcca   960
aaagaagcca atgcctttgt ggaatatatg acccgtccag aagtcatgca aaaatactac   1020
gatgtggacg gatctccaac agcgatcgaa ggggtcaaac aagcaggaga agattcaccg   1080
cttgctggta tgaccgaata tgcctttacg gatcgtcact tggtctggtt gcaacaatac   1140
tggaccagtg aagcagactt ccataccttg accatgaact atgtcttgac cggtgataaa   1200
caaggcatgg tcaatgattt gaatgccttc tttaacccga tgaaagcgga tgtggat      1257

<210>   3944
<211>   419
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar ABC transporter, sugar-binding protein (msmE)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903754 (0.E+01)

<400>   3944
Met Glu Trp Tyr Lys Lys Ile Gly Leu Leu Ala Thr Thr Gly Leu Ala 
1               5                   10                  15      

Leu Phe Gly Leu Gly Ala Cys Ser Asn Tyr Gly Lys Ser Ala Asp Gly 
            20                  25                  30          

Thr Val Thr Ile Glu Tyr Phe Asn Gln Lys Lys Glu Met Thr Lys Thr 
        35                  40                  45              

Leu Glu Glu Ile Thr Arg Asp Phe Glu Lys Glu Asn Pro Lys Ile Lys 
    50                  55                  60                  

Val Lys Val Val Asn Val Pro Asn Ala Gly Glu Val Leu Lys Thr Arg 
65                  70                  75                  80  

Val Leu Ala Gly Asp Val Pro Asp Val Val Asn Ile Tyr Pro Gln Ser 
                85                  90                  95      

Ile Glu Leu Gln Glu Trp Ala Lys Ala Gly Val Phe Glu Asp Leu Ser 
            100                 105                 110         

Asn Lys Asp Tyr Leu Lys Arg Val Lys Asn Gly Tyr Ala Glu Lys Tyr 
        115                 120                 125             

Ala Val Asn Glu Lys Val Tyr Asn Val Pro Phe Thr Ala Asn Ala Tyr 
    130                 135                 140                 

Gly Ile Tyr Tyr Asn Lys Asp Lys Phe Glu Glu Leu Gly Leu Lys Val 
145                 150                 155                 160 

Pro Glu Thr Trp Asp Glu Phe Glu Gln Leu Val Lys Asp Ile Val Ala 
                165                 170                 175     

Lys Gly Gln Thr Pro Phe Gly Ile Ala Gly Ala Asp Ala Trp Thr Leu 
            180                 185                 190         

Asn Gly Tyr Asn Gln Leu Ala Phe Ala Thr Ala Thr Gly Gly Gly Lys 
        195                 200                 205             

Glu Ala Asn Gln Tyr Leu Arg Tyr Ser Gln Pro Asn Ala Ile Lys Leu 
    210                 215                 220                 

Ser Asp Pro Ile Met Lys Asp Asp Ile Lys Val Met Asp Ile Leu Arg 
225                 230                 235                 240 

Ile Asn Gly Ser Lys Gln Lys Asn Trp Glu Gly Ala Gly Tyr Thr Asp 
                245                 250                 255     

Val Ile Gly Ala Phe Ala Arg Gly Asp Val Leu Met Thr Pro Asn Gly 
            260                 265                 270         

Ser Trp Ala Ile Thr Ala Ile Asn Glu Gln Lys Pro Asn Phe Lys Ile 
        275                 280                 285             

Gly Thr Phe Met Ile Pro Gly Lys Glu Lys Gly Gln Ser Leu Thr Val 
    290                 295                 300                 

Gly Ala Gly Asp Leu Ala Trp Ser Ile Ser Ala Thr Thr Lys His Pro 
305                 310                 315                 320 

Lys Glu Ala Asn Ala Phe Val Glu Tyr Met Thr Arg Pro Glu Val Met 
                325                 330                 335     

Gln Lys Tyr Tyr Asp Val Asp Gly Ser Pro Thr Ala Ile Glu Gly Val 
            340                 345                 350         

Lys Gln Ala Gly Glu Asp Ser Pro Leu Ala Gly Met Thr Glu Tyr Ala 
        355                 360                 365             

Phe Thr Asp Arg His Leu Val Trp Leu Gln Gln Tyr Trp Thr Ser Glu 
    370                 375                 380                 

Ala Asp Phe His Thr Leu Thr Met Asn Tyr Val Leu Thr Gly Asp Lys 
385                 390                 395                 400 

Gln Gly Met Val Asn Asp Leu Asn Ala Phe Phe Asn Pro Met Lys Ala 
                405                 410                 415     

Asp Val Asp 
            

<210>   3945
<211>   2160
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3945
atgggagtta ggatagagaa taatctattt tatgttgaga gtaaaaatct aagtttgatt   60
attgaaaatc gaaatggcta cttacttttg aaacatttag gaaagactat taagaactat   120
aaaggttcca atagtgttta tgaacgagac catgcctttt caggaaatcc aacggctact   180
aatcgaacct ttagtttaga tactcagcga cagatttttg gacaacatgg cttaggagat   240
tttaggaaac caaccataca ggttcagcat agtgtaactg aagtaacaga ctttcgattt   300
gtagaagcaa agattttaaa aggtcagaat ggtccacagg gcttaccttc tccacatagc   360
atggacgata cagagactct tgtcttaatg ttagaagatt ctaaggctca acttagtctg   420
actttgtatt atactacttt taataatgat gcgactattg ctagctacag taaattagat   480
aataatagta atcaggaagt tgtcatccat aaagattttt cttttatggc tgattttcca   540
gctgcagatt acgaaatagt aactctgcag ggtgcttatg ctcgtgaaaa gactgttaga   600
cgtcaacagg tagaacaagg aatcttttcg attagttcaa accgaggtgc ttctggtcat   660
gctcaaacac cagctcttct actatgcgaa caaggagtca cagaggatgc tgggaatgtg   720
tttgctattc aactaatgta tagtggcaac tttgaagctt ttgttcaaaa aaatcaattg   780
aatgaagttc gggtggctat tggcattaat ccagaaaact tttcttggaa gttagctcct   840
gaggaatact ttgaaacacc ggtagcttta gtgactcatt cagatcaggg attaactggt   900
attagtcatg aaagtcagaa ttttgtactg aagcacatta tgctaagtga attttctaaa   960
aaagaacgtc caattctaat caataactgg gaagctactt actttgactt tcagagagaa   1020
aaactgttag agttagcaga tgaagctaag aaagttggca ttgaactttt tgtattagat   1080
gatggttggt ttggcaatcg ttttgatgat aatcgtgctt taggtgattg ggttgttaat   1140
gaggaaaaac tgggtggaag tctagaaagt ctgatttcag ctatccatga aagaggtttg   1200
cagtttggac tttggttaga acccgaaatg atttctgtag atagtgattt gtatcgtcaa   1260
catcctgact gggctattca ggttcctggc tatgagcata cttattctcg gaatcaatta   1320
gtacttaatc ttgccaatcc tcaggtagta gaatacttga aaagtgtctt agatcaactc   1380
ctattttatc atgatattga ttacattaaa tgggatatga accgcaatat cactaagcta   1440
gggaatggat taacttatct agagacacag atgcaatctc atcagtacat gctggggctt   1500
tatgaactcg tttcttatct gacagagaag cacagccata ttctctttga gtcctgctct   1560
ggtggtggtg gacgaaatga tcttggtatg atgcgctatt tcccacaagt ctgggctagt   1620
gataatactg atgccattgc acgtttacca attcaatacg gttcatccta tctctatcca   1680
accatttcta tgggggctca tgtgtcagca gtaccgaatc atcagatggg acgaatgaca   1740
ccattagaaa cacgtggcct tgtagcaatg atgggaaatt tgggctatga acttgatttg   1800
acaaatttat cagatgaaga gaaagctacg attgctaatc aggtgaactt gtataaagaa   1860
ttacgaccag tagttcagtt aggacagcag tatagactaa ttaatcctga tactgtatcc   1920
aatgaagcag ctgtacaatt taattacgga aatcaaacga ttgtaaccta cgttcgcgtt   1980
ttatctgttg tagagaccat ggaaacaact ttaaaattaa aagatttgga tgaagaggga   2040
ctatataaat tacaggaaaa tggcgaagtt tactcaggtg cagaactaat gtatgcgggc   2100
ttaactgtta tcttatccca aggagatttt ttgagtagac agtatatttt tagaaaacta   2160

<210>   3946
<211>   720
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alpha-galactosidase (aga)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903755 (0.E+01)

<400>   3946
Met Gly Val Arg Ile Glu Asn Asn Leu Phe Tyr Val Glu Ser Lys Asn 
1               5                   10                  15      

Leu Ser Leu Ile Ile Glu Asn Arg Asn Gly Tyr Leu Leu Leu Lys His 
            20                  25                  30          

Leu Gly Lys Thr Ile Lys Asn Tyr Lys Gly Ser Asn Ser Val Tyr Glu 
        35                  40                  45              

Arg Asp His Ala Phe Ser Gly Asn Pro Thr Ala Thr Asn Arg Thr Phe 
    50                  55                  60                  

Ser Leu Asp Thr Gln Arg Gln Ile Phe Gly Gln His Gly Leu Gly Asp 
65                  70                  75                  80  

Phe Arg Lys Pro Thr Ile Gln Val Gln His Ser Val Thr Glu Val Thr 
                85                  90                  95      

Asp Phe Arg Phe Val Glu Ala Lys Ile Leu Lys Gly Gln Asn Gly Pro 
            100                 105                 110         

Gln Gly Leu Pro Ser Pro His Ser Met Asp Asp Thr Glu Thr Leu Val 
        115                 120                 125             

Leu Met Leu Glu Asp Ser Lys Ala Gln Leu Ser Leu Thr Leu Tyr Tyr 
    130                 135                 140                 

Thr Thr Phe Asn Asn Asp Ala Thr Ile Ala Ser Tyr Ser Lys Leu Asp 
145                 150                 155                 160 

Asn Asn Ser Asn Gln Glu Val Val Ile His Lys Asp Phe Ser Phe Met 
                165                 170                 175     

Ala Asp Phe Pro Ala Ala Asp Tyr Glu Ile Val Thr Leu Gln Gly Ala 
            180                 185                 190         

Tyr Ala Arg Glu Lys Thr Val Arg Arg Gln Gln Val Glu Gln Gly Ile 
        195                 200                 205             

Phe Ser Ile Ser Ser Asn Arg Gly Ala Ser Gly His Ala Gln Thr Pro 
    210                 215                 220                 

Ala Leu Leu Leu Cys Glu Gln Gly Val Thr Glu Asp Ala Gly Asn Val 
225                 230                 235                 240 

Phe Ala Ile Gln Leu Met Tyr Ser Gly Asn Phe Glu Ala Phe Val Gln 
                245                 250                 255     

Lys Asn Gln Leu Asn Glu Val Arg Val Ala Ile Gly Ile Asn Pro Glu 
            260                 265                 270         

Asn Phe Ser Trp Lys Leu Ala Pro Glu Glu Tyr Phe Glu Thr Pro Val 
        275                 280                 285             

Ala Leu Val Thr His Ser Asp Gln Gly Leu Thr Gly Ile Ser His Glu 
    290                 295                 300                 

Ser Gln Asn Phe Val Leu Lys His Ile Met Leu Ser Glu Phe Ser Lys 
305                 310                 315                 320 

Lys Glu Arg Pro Ile Leu Ile Asn Asn Trp Glu Ala Thr Tyr Phe Asp 
                325                 330                 335     

Phe Gln Arg Glu Lys Leu Leu Glu Leu Ala Asp Glu Ala Lys Lys Val 
            340                 345                 350         

Gly Ile Glu Leu Phe Val Leu Asp Asp Gly Trp Phe Gly Asn Arg Phe 
        355                 360                 365             

Asp Asp Asn Arg Ala Leu Gly Asp Trp Val Val Asn Glu Glu Lys Leu 
    370                 375                 380                 

Gly Gly Ser Leu Glu Ser Leu Ile Ser Ala Ile His Glu Arg Gly Leu 
385                 390                 395                 400 

Gln Phe Gly Leu Trp Leu Glu Pro Glu Met Ile Ser Val Asp Ser Asp 
                405                 410                 415     

Leu Tyr Arg Gln His Pro Asp Trp Ala Ile Gln Val Pro Gly Tyr Glu 
            420                 425                 430         

His Thr Tyr Ser Arg Asn Gln Leu Val Leu Asn Leu Ala Asn Pro Gln 
        435                 440                 445             

Val Val Glu Tyr Leu Lys Ser Val Leu Asp Gln Leu Leu Phe Tyr His 
    450                 455                 460                 

Asp Ile Asp Tyr Ile Lys Trp Asp Met Asn Arg Asn Ile Thr Lys Leu 
465                 470                 475                 480 

Gly Asn Gly Leu Thr Tyr Leu Glu Thr Gln Met Gln Ser His Gln Tyr 
                485                 490                 495     

Met Leu Gly Leu Tyr Glu Leu Val Ser Tyr Leu Thr Glu Lys His Ser 
            500                 505                 510         

His Ile Leu Phe Glu Ser Cys Ser Gly Gly Gly Gly Arg Asn Asp Leu 
        515                 520                 525             

Gly Met Met Arg Tyr Phe Pro Gln Val Trp Ala Ser Asp Asn Thr Asp 
    530                 535                 540                 

Ala Ile Ala Arg Leu Pro Ile Gln Tyr Gly Ser Ser Tyr Leu Tyr Pro 
545                 550                 555                 560 

Thr Ile Ser Met Gly Ala His Val Ser Ala Val Pro Asn His Gln Met 
                565                 570                 575     

Gly Arg Met Thr Pro Leu Glu Thr Arg Gly Leu Val Ala Met Met Gly 
            580                 585                 590         

Asn Leu Gly Tyr Glu Leu Asp Leu Thr Asn Leu Ser Asp Glu Glu Lys 
        595                 600                 605             

Ala Thr Ile Ala Asn Gln Val Asn Leu Tyr Lys Glu Leu Arg Pro Val 
    610                 615                 620                 

Val Gln Leu Gly Gln Gln Tyr Arg Leu Ile Asn Pro Asp Thr Val Ser 
625                 630                 635                 640 

Asn Glu Ala Ala Val Gln Phe Asn Tyr Gly Asn Gln Thr Ile Val Thr 
                645                 650                 655     

Tyr Val Arg Val Leu Ser Val Val Glu Thr Met Glu Thr Thr Leu Lys 
            660                 665                 670         

Leu Lys Asp Leu Asp Glu Glu Gly Leu Tyr Lys Leu Gln Glu Asn Gly 
        675                 680                 685             

Glu Val Tyr Ser Gly Ala Glu Leu Met Tyr Ala Gly Leu Thr Val Ile 
    690                 695                 700                 

Leu Ser Gln Gly Asp Phe Leu Ser Arg Gln Tyr Ile Phe Arg Lys Leu 
705                 710                 715                 720 


<210>   3947
<211>   858
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3947
atgttagttt tttcagaata ccagactgga acaatcgacc ttgccctaag cttttatgga   60
tatgaggaat gcacacctaa ttactctttt ggtccagcca ttcgtgatac atacgttcta   120
cattacatta ctaaaggaca aggaaaattt cattacaagg gtaaaattgt tgatttaaaa   180
gaaggagatt tctttctatt aaaaccagag gaactaacct tttatcaagc agatagtaaa   240
gaaccttggg cctactactg gttaggaatc actggaggga aagcccctga ttattttgct   300
ctttcccaaa tttctgatca atcctatctc atccaatctg aaacttgtca tacccagact   360
actgcaaaac tcatctcaga cattgtccgc ttcgctcaga ttacaaaatc aagtgaatta   420
gctcaactcc atatcatggg acaacttcat gaactgatgt ttcatctggg aactattgct   480
cccaatcaga aaaaaaagaa tatttcatca acccaccaac tctatcttga atgcaaacga   540
ttaattgata gccactatcc tcaatcactt acaattcaag atttagcaaa agaactatcc   600
gttcacagaa gctacttatc aagcgtattc aaagaattta ataccttatc acccaaagaa   660
tacctactct acgttcgaat gcaccgagct agacaacttc tcgaaaatac ccaagagtcc   720
atcaaggtaa ttgcatactc ggtaggtttt tcagatccac tccatttttc gaaagcttat   780
aaacaatact ttaatcagac tccaagtcat acaagaaaag aatactctca ataccaacta   840
gtaagaaagg caacatta                                                 858

<210>   3948
<211>   286
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   msm operon regulatory protein (msmR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903756 (e-166)

<400>   3948
Met Leu Val Phe Ser Glu Tyr Gln Thr Gly Thr Ile Asp Leu Ala Leu 
1               5                   10                  15      

Ser Phe Tyr Gly Tyr Glu Glu Cys Thr Pro Asn Tyr Ser Phe Gly Pro 
            20                  25                  30          

Ala Ile Arg Asp Thr Tyr Val Leu His Tyr Ile Thr Lys Gly Gln Gly 
        35                  40                  45              

Lys Phe His Tyr Lys Gly Lys Ile Val Asp Leu Lys Glu Gly Asp Phe 
    50                  55                  60                  

Phe Leu Leu Lys Pro Glu Glu Leu Thr Phe Tyr Gln Ala Asp Ser Lys 
65                  70                  75                  80  

Glu Pro Trp Ala Tyr Tyr Trp Leu Gly Ile Thr Gly Gly Lys Ala Pro 
                85                  90                  95      

Asp Tyr Phe Ala Leu Ser Gln Ile Ser Asp Gln Ser Tyr Leu Ile Gln 
            100                 105                 110         

Ser Glu Thr Cys His Thr Gln Thr Thr Ala Lys Leu Ile Ser Asp Ile 
        115                 120                 125             

Val Arg Phe Ala Gln Ile Thr Lys Ser Ser Glu Leu Ala Gln Leu His 
    130                 135                 140                 

Ile Met Gly Gln Leu His Glu Leu Met Phe His Leu Gly Thr Ile Ala 
145                 150                 155                 160 

Pro Asn Gln Lys Lys Lys Asn Ile Ser Ser Thr His Gln Leu Tyr Leu 
                165                 170                 175     

Glu Cys Lys Arg Leu Ile Asp Ser His Tyr Pro Gln Ser Leu Thr Ile 
            180                 185                 190         

Gln Asp Leu Ala Lys Glu Leu Ser Val His Arg Ser Tyr Leu Ser Ser 
        195                 200                 205             

Val Phe Lys Glu Phe Asn Thr Leu Ser Pro Lys Glu Tyr Leu Leu Tyr 
    210                 215                 220                 

Val Arg Met His Arg Ala Arg Gln Leu Leu Glu Asn Thr Gln Glu Ser 
225                 230                 235                 240 

Ile Lys Val Ile Ala Tyr Ser Val Gly Phe Ser Asp Pro Leu His Phe 
                245                 250                 255     

Ser Lys Ala Tyr Lys Gln Tyr Phe Asn Gln Thr Pro Ser His Thr Arg 
            260                 265                 270         

Lys Glu Tyr Ser Gln Tyr Gln Leu Val Arg Lys Ala Thr Leu 
        275                 280                 285     

<210>   3949
<211>   933
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3949
atgaaatcct accaagctgt ctaccaaatc ctatctaaag aaaccgacta tatcagcgga   60
gaaaaaatcg cagaaaaact atccctaagc cgaacagcaa tttggaaagc catcaagcga   120
ctagaacaag aaggcattga aattgatagt atcaaaaata gaggatataa actgatgaat   180
ggtgacctta ttcttccaga gattctagaa gaaaatcttc caattaaagt cagctttaaa   240
cccgaaacaa aatcaacaca actagatgca aaagaagcaa ttgatttagg ccatgaagca   300
aataccctct atctagcttc ctatcaaaca gcaggccgag gccgttttca acgttccttc   360
tactcaccac aaggtggtat ttatatgaca ctccatctta aaccaaatct cccctatgac   420
aaattaccat cctacacact acttgtagct ggagctgtct acaaagccat taagaaccta   480
actttaatag atgtcgacat aaaatgggtc aatgatatct atctaaacaa tcataaaatt   540
ggaggaatcc ttactgaagc aatgacctct gtagaaactg gcttagtcac agatatcatt   600
attggagtag gtatcaattt cactattaaa gacttccctc aggaattaaa agaaaaagct   660
gccagcttat ttaaagctac agctcctata acaaggaatg aattgatcat agaaatctgg   720
cgtgctttct tcgaaacacc agcagaagag ctattatacc tatacaaaaa acagtcattc   780
attctaggaa aagaagtcac tttcacacta gagcaaaaag actacaaggg acttgctaaa   840
gacatctcag aaaatggaaa acttttagtt caatgtgata acggaaaaga aatctggcta   900
aatagtggcg aaatttctct caatagttgg aag                                933

<210>   3950
<211>   311
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   BirA bifunctional protein (birA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903757 (e-177)

<400>   3950
Met Lys Ser Tyr Gln Ala Val Tyr Gln Ile Leu Ser Lys Glu Thr Asp 
1               5                   10                  15      

Tyr Ile Ser Gly Glu Lys Ile Ala Glu Lys Leu Ser Leu Ser Arg Thr 
            20                  25                  30          

Ala Ile Trp Lys Ala Ile Lys Arg Leu Glu Gln Glu Gly Ile Glu Ile 
        35                  40                  45              

Asp Ser Ile Lys Asn Arg Gly Tyr Lys Leu Met Asn Gly Asp Leu Ile 
    50                  55                  60                  

Leu Pro Glu Ile Leu Glu Glu Asn Leu Pro Ile Lys Val Ser Phe Lys 
65                  70                  75                  80  

Pro Glu Thr Lys Ser Thr Gln Leu Asp Ala Lys Glu Ala Ile Asp Leu 
                85                  90                  95      

Gly His Glu Ala Asn Thr Leu Tyr Leu Ala Ser Tyr Gln Thr Ala Gly 
            100                 105                 110         

Arg Gly Arg Phe Gln Arg Ser Phe Tyr Ser Pro Gln Gly Gly Ile Tyr 
        115                 120                 125             

Met Thr Leu His Leu Lys Pro Asn Leu Pro Tyr Asp Lys Leu Pro Ser 
    130                 135                 140                 

Tyr Thr Leu Leu Val Ala Gly Ala Val Tyr Lys Ala Ile Lys Asn Leu 
145                 150                 155                 160 

Thr Leu Ile Asp Val Asp Ile Lys Trp Val Asn Asp Ile Tyr Leu Asn 
                165                 170                 175     

Asn His Lys Ile Gly Gly Ile Leu Thr Glu Ala Met Thr Ser Val Glu 
            180                 185                 190         

Thr Gly Leu Val Thr Asp Ile Ile Ile Gly Val Gly Ile Asn Phe Thr 
        195                 200                 205             

Ile Lys Asp Phe Pro Gln Glu Leu Lys Glu Lys Ala Ala Ser Leu Phe 
    210                 215                 220                 

Lys Ala Thr Ala Pro Ile Thr Arg Asn Glu Leu Ile Ile Glu Ile Trp 
225                 230                 235                 240 

Arg Ala Phe Phe Glu Thr Pro Ala Glu Glu Leu Leu Tyr Leu Tyr Lys 
                245                 250                 255     

Lys Gln Ser Phe Ile Leu Gly Lys Glu Val Thr Phe Thr Leu Glu Gln 
            260                 265                 270         

Lys Asp Tyr Lys Gly Leu Ala Lys Asp Ile Ser Glu Asn Gly Lys Leu 
        275                 280                 285             


Leu Val Gln Cys Asp Asn Gly Lys Glu Ile Trp Leu Asn Ser Gly Glu 
    290                 295                 300                 

Ile Ser Leu Asn Ser Trp Lys 
305                 310     

<210>   3951
<211>   1353
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3951
atgaatctga aagtgaaaca aaaaatacca ttaaaaatca agcgcatggg aattaacggt   60
gagggaatcg gcttttacca aaaaacatta gtctttgtac caggagctct caaaggcgaa   120
gatatctatt gtcagattac ttctattaga cgcaactttg ttgaagcaaa attactgaag   180
gtcaacaaga agtctaaatt tcgaattgtg ccatcttgta ctatttataa tgaatgcgga   240
ggctgccaaa tcatgcacct gcattatgat aagcagctgg agttcaagac ggacttactt   300
catcaagcgc tgaaaaaatt tgctcctgca ggatatgaaa attatgaaat tcgtccaact   360
attggaatgc aggaaccaaa atattacaga gctaagttac aatttcagac tcgaaaattt   420
aaaaatcagg tcaaggcggg cttatatgca caaaactctc actatttagt agagttgaaa   480
gactgcctgg tacaagataa ggaaacccaa gtgattgcta atcgcttagc agaattactt   540
acttatcacc agattccaat cacggatgag agaaaagttc taggtgtccg tactattatg   600
gtccgacgcg cgagaaagac cggacaggtt cagattatta ttgttacaaa ccgccagctt   660
aatttaactc aattggtaaa agagttggtt aaagatttcc cagaagttgt gacagtagct   720
gttaatacaa atacagctaa aaccagtgag atatatggtg aaaagacaga gattatctgg   780
gggcaagaga gtattcaaga aggtgtactc aattatgaat tttcactatc ccctcgagct   840
ttttatcaac taaatcctga gcaaacagaa gtcctctata gcgaagcagt aaaagcgctg   900
gatgttgata aagaagacca tttgattgac gcttattgtg gagttggaac gattggattt   960
gcctttgcaa agaaagtaaa aacactcaga ggtatggata ttattccaga agctattgaa   1020
gatgccaagc gaaatgctaa aagaatggga tttgacaata ctcattatga agctggaacg   1080
gcagaagaga ttattcctcg ttggtacaag gaaggctacc gagcagatgc tttgattgtt   1140
gacccaccac gtacaggtct ggatgataag ttattagata ctattcttac ttatgtacca   1200
gaaaaaatgg tttatatttc ttgtaatgtt tcgaccttgg ctcgtgattt ggtacgctta   1260
gtagaagtct atgatcttca ttatatccag tcggtcgata tgttcccaca tacagctcga   1320
actgaagctg ttgtaaaatt aataaaaaaa gtt                                1353

<210>   3952
<211>   451
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   RNA methyltransferase, TrmA family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903759 (0.E+01)

<400>   3952
Met Asn Leu Lys Val Lys Gln Lys Ile Pro Leu Lys Ile Lys Arg Met 
1               5                   10                  15      

Gly Ile Asn Gly Glu Gly Ile Gly Phe Tyr Gln Lys Thr Leu Val Phe 
            20                  25                  30          

Val Pro Gly Ala Leu Lys Gly Glu Asp Ile Tyr Cys Gln Ile Thr Ser 
        35                  40                  45              

Ile Arg Arg Asn Phe Val Glu Ala Lys Leu Leu Lys Val Asn Lys Lys 
    50                  55                  60                  

Ser Lys Phe Arg Ile Val Pro Ser Cys Thr Ile Tyr Asn Glu Cys Gly 
65                  70                  75                  80  

Gly Cys Gln Ile Met His Leu His Tyr Asp Lys Gln Leu Glu Phe Lys 
                85                  90                  95      

Thr Asp Leu Leu His Gln Ala Leu Lys Lys Phe Ala Pro Ala Gly Tyr 
            100                 105                 110         

Glu Asn Tyr Glu Ile Arg Pro Thr Ile Gly Met Gln Glu Pro Lys Tyr 
        115                 120                 125             

Tyr Arg Ala Lys Leu Gln Phe Gln Thr Arg Lys Phe Lys Asn Gln Val 
    130                 135                 140                 

Lys Ala Gly Leu Tyr Ala Gln Asn Ser His Tyr Leu Val Glu Leu Lys 
145                 150                 155                 160 

Asp Cys Leu Val Gln Asp Lys Glu Thr Gln Val Ile Ala Asn Arg Leu 
                165                 170                 175     

Ala Glu Leu Leu Thr Tyr His Gln Ile Pro Ile Thr Asp Glu Arg Lys 
            180                 185                 190         

Val Leu Gly Val Arg Thr Ile Met Val Arg Arg Ala Arg Lys Thr Gly 
        195                 200                 205             

Gln Val Gln Ile Ile Ile Val Thr Asn Arg Gln Leu Asn Leu Thr Gln 
    210                 215                 220                 

Leu Val Lys Glu Leu Val Lys Asp Phe Pro Glu Val Val Thr Val Ala 
225                 230                 235                 240 

Val Asn Thr Asn Thr Ala Lys Thr Ser Glu Ile Tyr Gly Glu Lys Thr 
                245                 250                 255     

Glu Ile Ile Trp Gly Gln Glu Ser Ile Gln Glu Gly Val Leu Asn Tyr 
            260                 265                 270         

Glu Phe Ser Leu Ser Pro Arg Ala Phe Tyr Gln Leu Asn Pro Glu Gln 
        275                 280                 285             

Thr Glu Val Leu Tyr Ser Glu Ala Val Lys Ala Leu Asp Val Asp Lys 
    290                 295                 300                 

Glu Asp His Leu Ile Asp Ala Tyr Cys Gly Val Gly Thr Ile Gly Phe 
305                 310                 315                 320 

Ala Phe Ala Lys Lys Val Lys Thr Leu Arg Gly Met Asp Ile Ile Pro 
                325                 330                 335     

Glu Ala Ile Glu Asp Ala Lys Arg Asn Ala Lys Arg Met Gly Phe Asp 
            340                 345                 350         

Asn Thr His Tyr Glu Ala Gly Thr Ala Glu Glu Ile Ile Pro Arg Trp 
        355                 360                 365             

Tyr Lys Glu Gly Tyr Arg Ala Asp Ala Leu Ile Val Asp Pro Pro Arg 
    370                 375                 380                 

Thr Gly Leu Asp Asp Lys Leu Leu Asp Thr Ile Leu Thr Tyr Val Pro 
385                 390                 395                 400 

Glu Lys Met Val Tyr Ile Ser Cys Asn Val Ser Thr Leu Ala Arg Asp 
                405                 410                 415     

Leu Val Arg Leu Val Glu Val Tyr Asp Leu His Tyr Ile Gln Ser Val 
            420                 425                 430         

Asp Met Phe Pro His Thr Ala Arg Thr Glu Ala Val Val Lys Leu Ile 
        435                 440                 445             

Lys Lys Val 
    450     

<210>   3953
<211>   858
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3953
atgcgcttga tttttaatgg tattttttgt ttcactttca gattcatacc cctatcttat   60
cacattttga gttataatag agctatgaaa atcacaaaac ttgaaaagaa aaaaagactc   120
tatctgatgg agcttgataa tggcgacaaa tgctatatca ccgaagacac aattgttcgt   180
tttatgttat cgagagataa ggtgataagc gaagaggaat tgaaagagat tcaagacttt   240
gctcaatttt cttatggtaa gaatctggcc ctctaccact tatcctttaa agcacgtact   300
gaaaaagagg tcagagaata tctgaaaaaa tatgatatta atgaaaacat cgtttctcaa   360
gtcattgcta atcttaaaga agagaagtgg attaatgata gccagtacgc ttatgctatc   420
atcaatgcca atcaactttc aggagacaag ggaccttatg tactgactca gaaattagca   480
caaaaaggaa tttcaaaatc tactatagaa gaaatcttga atgattttga tttttcggaa   540
gttgctcaac gtgtagccaa taaactattg aaaaaatatg agggaaaact tccagctcgt   600
gccctgcaag ataagattat ccagaacttg actaacaagg gcttctctta ttttgatgct   660
aaaattgcct ttgacgaatt ggatagtcaa gttgatgaag aaacgactca ggaactcatc   720
ttcaaggaac ttgataagca atatactaag tatgcccgaa agtatgaagg atacgaactg   780
aagcagcgtt taactcaagt tttagcacga aagggctacg atttttcgga tatagcaagc   840
gctcttagag aatatctt                                                 858

<210>   3954
<211>   286
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903760 (e-139)

<400>   3954
Met Arg Leu Ile Phe Asn Gly Ile Phe Cys Phe Thr Phe Arg Phe Ile 
1               5                   10                  15      

Pro Leu Ser Tyr His Ile Leu Ser Tyr Asn Arg Ala Met Lys Ile Thr 

            20                  25                  30          

Lys Leu Glu Lys Lys Lys Arg Leu Tyr Leu Met Glu Leu Asp Asn Gly 
        35                  40                  45              

Asp Lys Cys Tyr Ile Thr Glu Asp Thr Ile Val Arg Phe Met Leu Ser 
    50                  55                  60                  

Arg Asp Lys Val Ile Ser Glu Glu Glu Leu Lys Glu Ile Gln Asp Phe 
65                  70                  75                  80  

Ala Gln Phe Ser Tyr Gly Lys Asn Leu Ala Leu Tyr His Leu Ser Phe 
                85                  90                  95      

Lys Ala Arg Thr Glu Lys Glu Val Arg Glu Tyr Leu Lys Lys Tyr Asp 
            100                 105                 110         

Ile Asn Glu Asn Ile Val Ser Gln Val Ile Ala Asn Leu Lys Glu Glu 
        115                 120                 125             

Lys Trp Ile Asn Asp Ser Gln Tyr Ala Tyr Ala Ile Ile Asn Ala Asn 
    130                 135                 140                 

Gln Leu Ser Gly Asp Lys Gly Pro Tyr Val Leu Thr Gln Lys Leu Ala 
145                 150                 155                 160 

Gln Lys Gly Ile Ser Lys Ser Thr Ile Glu Glu Ile Leu Asn Asp Phe 
                165                 170                 175     

Asp Phe Ser Glu Val Ala Gln Arg Val Ala Asn Lys Leu Leu Lys Lys 
            180                 185                 190         

Tyr Glu Gly Lys Leu Pro Ala Arg Ala Leu Gln Asp Lys Ile Ile Gln 
        195                 200                 205             

Asn Leu Thr Asn Lys Gly Phe Ser Tyr Phe Asp Ala Lys Ile Ala Phe 
    210                 215                 220                 

Asp Glu Leu Asp Ser Gln Val Asp Glu Glu Thr Thr Gln Glu Leu Ile 
225                 230                 235                 240 

Phe Lys Glu Leu Asp Lys Gln Tyr Thr Lys Tyr Ala Arg Lys Tyr Glu 
                245                 250                 255     

Gly Tyr Glu Leu Lys Gln Arg Leu Thr Gln Val Leu Ala Arg Lys Gly 
            260                 265                 270         

Tyr Asp Phe Ser Asp Ile Ala Ser Ala Leu Arg Glu Tyr Leu 
        275                 280                 285     

<210>   3955
<211>   531
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3955
atgaagcttc caaaagaagg cgactttatt acaattcaaa gttataagca tgatgggagt   60
ctccaccgaa cttggcggga caccatggta ctaaaaacaa cagaaaacgc cattattggt   120
gtcaacgatc atacacttgt taccgaaagt gatggtcgtc gttgggtcac tcgagaaccg   180
gctattgttt actttcacaa gaaatattgg tttaatatca ttgccatgat tcgtgataat   240
ggaacttctt actattgcaa tatggctagc ccctactatc tggatgaaga agcactgaag   300
tatattgatt acgatttgga tgttaaaatt tttacagatg gggaaaaacg tctcttggac   360
gttgaagagt acgagcgtca caaacgcaaa atgaattatt ctgatgactt ggactatatt   420
ttaaaagaac atgtcaaaat tcttgttgat tggattaaca atggacgtgg tcctttctca   480
gaagcctatg taaacatttg gtacaagcgc tatgtagaac taaagaatcg g            531

<210>   3956
<211>   177
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903761 (e-106)

<400>   3956
Met Lys Leu Pro Lys Glu Gly Asp Phe Ile Thr Ile Gln Ser Tyr Lys 
1               5                   10                  15      

His Asp Gly Ser Leu His Arg Thr Trp Arg Asp Thr Met Val Leu Lys 
            20                  25                  30          

Thr Thr Glu Asn Ala Ile Ile Gly Val Asn Asp His Thr Leu Val Thr 
        35                  40                  45              

Glu Ser Asp Gly Arg Arg Trp Val Thr Arg Glu Pro Ala Ile Val Tyr 
    50                  55                  60                  

Phe His Lys Lys Tyr Trp Phe Asn Ile Ile Ala Met Ile Arg Asp Asn 
65                  70                  75                  80  

Gly Thr Ser Tyr Tyr Cys Asn Met Ala Ser Pro Tyr Tyr Leu Asp Glu 
                85                  90                  95      

Glu Ala Leu Lys Tyr Ile Asp Tyr Asp Leu Asp Val Lys Ile Phe Thr 
            100                 105                 110         

Asp Gly Glu Lys Arg Leu Leu Asp Val Glu Glu Tyr Glu Arg His Lys 
        115                 120                 125             

Arg Lys Met Asn Tyr Ser Asp Asp Leu Asp Tyr Ile Leu Lys Glu His 
    130                 135                 140                 

Val Lys Ile Leu Val Asp Trp Ile Asn Asn Gly Arg Gly Pro Phe Ser 
145                 150                 155                 160 

Glu Ala Tyr Val Asn Ile Trp Tyr Lys Arg Tyr Val Glu Leu Lys Asn 
                165                 170                 175     

Arg 
    

<210>   3957
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3957
atgaaattaa aaaaattatt aaaggatgac acaaaagttt ttgaaaaatc tacattcaaa   60
tttgtagaag gatataaaat atacctgaca gaatctaaag aatctggaat taaacaaatg   120
gacaatgtca taaaatattt tgagtttatt gaatctaaaa gtattgcttt atattttcaa   180
aaacgattaa atgagctgat agat                                          204

<210>   3958
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903762 (7.E-34)

<400>   3958
Met Lys Leu Lys Lys Leu Leu Lys Asp Asp Thr Lys Val Phe Glu Lys 
1               5                   10                  15      

Ser Thr Phe Lys Phe Val Glu Gly Tyr Lys Ile Tyr Leu Thr Glu Ser 
            20                  25                  30          

Lys Glu Ser Gly Ile Lys Gln Met Asp Asn Val Ile Lys Tyr Phe Glu 
        35                  40                  45              

Phe Ile Glu Ser Lys Ser Ile Ala Leu Tyr Phe Gln Lys Arg Leu Asn 
    50                  55                  60                  

Glu Leu Ile Asp 
65              

<210>   3959
<211>   1304
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3959
atggaacaat tacattttat cacaaaactg ctcgatatta aagaccctaa tatccagatt   60
ttagacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accttctaaa   180
attccttatc ttgaaacgac tggtatgcct tctagaattc tccttagaaa gcgtcgtttc   240
aagtgctatc actgttcaaa aatgatggtt gctgagactc ccctggtaaa gaaaaatcac   300
caaatccctc gtatcatcaa ccaaaagatt gctcaaaagt taattgaaaa aatttctatg   360
actgatattg cccatcagct ggccatttca acttcaactg tcattcgcaa gctcaatgac   420
tttcactttg agcatgattt ttctcggctt ccaaagatta tgtcttggga tgagtatgcc   480
ttcactaagg gaaagatgag tttcattgcg caagattttg ataatcttaa tattatcact   540
gttcttgaag gcagaacaca agctgtcatc cgaaatcact ttcttcgcta cgatagagcc   600
gttcgttgtc aagtgaaaat cattacgatg gatatgttta gtccttacta tgacttggct   660
aaacagcttc gctttcaaat ttctaggctc aggctgaaac agtctcccag actgtttcac   720
tcccgaatgc taaaatcgtg ttggatcgct ttcacattgt acaacatctt agccgtgcta   780
tgagtcgtgt gcgtgttcaa attatgaacc aattggatcg aaaatcccat gaatacaagg   840
ctatcaagcg ctactggaag ctcatacaac aggatagccg taaactgagt gataagcgat   900
tttatcgtcc tacttttcgt atgcatttaa ccaataaaga gattttagac aagcttttga   960
gctattcaca agacttgaaa catcactatc agctctatca actcttgctg tttcactttc   1020
agaataagga accggagaaa tttttcggac ttattgagga caatcttaag caagttcatc   1080
ctatttttca gactgtcttt aaaaccttcc tcaaagataa agaaaagatt atcaacgccc   1140
ttcaactaca ctattctaac gccaaaccgg aagcgaccaa taatctcatc aaacttatca   1200
agcgcaatgc ctttggtttt cgaaactttg aaaacttcaa aaaacggatt tttatcgctt   1260
tgaacatcaa aaaagaaagg acgaaatttg tcctttctcg agct                    1304

<210>   3960
<211>   260
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase FRAMESHIFT

<400>   3960
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Ile Gln Ile Leu Asp Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Ser Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Pro Leu Val 
                85                  90                  95      

Lys Lys Asn His Gln Ile Pro Arg Ile Ile Asn Gln Lys Ile Ala Gln 
            100                 105                 110         

Lys Leu Ile Glu Lys Ile Ser Met Thr Asp Ile Ala His Gln Leu Ala 
        115                 120                 125             

Ile Ser Thr Ser Thr Val Ile Arg Lys Leu Asn Asp Phe His Phe Glu 
    130                 135                 140                 

His Asp Phe Ser Arg Leu Pro Lys Ile Met Ser Trp Asp Glu Tyr Ala 
145                 150                 155                 160 

Phe Thr Lys Gly Lys Met Ser Phe Ile Ala Gln Asp Phe Asp Asn Leu 
                165                 170                 175     

Asn Ile Ile Thr Val Leu Glu Gly Arg Thr Gln Ala Val Ile Arg Asn 
            180                 185                 190         

His Phe Leu Arg Tyr Asp Arg Ala Val Arg Cys Gln Val Lys Ile Ile 
        195                 200                 205             

Thr Met Asp Met Phe Ser Pro Tyr Tyr Asp Leu Ala Lys Gln Leu Arg 
    210                 215                 220                 

Phe Gln Ile Ser Arg Leu Arg Leu Lys Gln Ser Pro Arg Leu Phe His 
225                 230                 235                 240 

Ser Arg Met Leu Lys Ser Cys Trp Ile Ala Phe Thr Leu Tyr Asn Ile 
                245                 250                 255     

Leu Ala Val Leu 
            260 

<210>   3961
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3961
gtgttggatc gctttcacat tgtacaacat cttagccgtg ctatgagtcg tgtgcgtgtt   60
caaattatga accaattgga tcgaaaatcc catgaataca aggctatcaa gcgctactgg   120
aagctcatac aacaggatag ccgtaaactg agtgataagc gattttatcg tcctactttt   180
cgtatgcatt taaccaataa agagatttta gacaagcttt tgagctattc acaagacttg   240
aaacatcact atcagctcta tcaactcttg ctgtttcact ttcagaataa ggaaccggag   300
aaatttttcg gacttattga ggacaatctt aagcaagttc atcctatttt tcagactgtc   360
tttaaaacct tcctcaaaga taaagaaaag attatcaacg cccttcaact acactattct   420
aacgccaaac cggaagcgac caataatctc atcaaactta tcaagcgcaa tgcctttggt   480
tttcgaaact ttgaaaactt caaaaaacgg atttttatcg ctttgaacat caaaaaagaa   540
aggacgaaat ttgtcctttc tcgagct                                       567

<210>   3962
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   3962
Met Leu Asp Arg Phe His Ile Val Gln His Leu Ser Arg Ala Met Ser 
1               5                   10                  15      

Arg Val Arg Val Gln Ile Met Asn Gln Leu Asp Arg Lys Ser His Glu 
            20                  25                  30          

Tyr Lys Ala Ile Lys Arg Tyr Trp Lys Leu Ile Gln Gln Asp Ser Arg 
        35                  40                  45              

Lys Leu Ser Asp Lys Arg Phe Tyr Arg Pro Thr Phe Arg Met His Leu 
    50                  55                  60                  

Thr Asn Lys Glu Ile Leu Asp Lys Leu Leu Ser Tyr Ser Gln Asp Leu 
65                  70                  75                  80  

Lys His His Tyr Gln Leu Tyr Gln Leu Leu Leu Phe His Phe Gln Asn 
                85                  90                  95      

Lys Glu Pro Glu Lys Phe Phe Gly Leu Ile Glu Asp Asn Leu Lys Gln 
            100                 105                 110         

Val His Pro Ile Phe Gln Thr Val Phe Lys Thr Phe Leu Lys Asp Lys 
        115                 120                 125             

Glu Lys Ile Ile Asn Ala Leu Gln Leu His Tyr Ser Asn Ala Lys Pro 
    130                 135                 140                 

Glu Ala Thr Asn Asn Leu Ile Lys Leu Ile Lys Arg Asn Ala Phe Gly 
145                 150                 155                 160 

Phe Arg Asn Phe Glu Asn Phe Lys Lys Arg Ile Phe Ile Ala Leu Asn 
                165                 170                 175     

Ile Lys Lys Glu Arg Thr Lys Phe Val Leu Ser Arg Ala 
            180                 185                 

<210>   3963
<211>   1620
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3963
atgtcaaaag aaattaaatt ttcatcagat gcccgttcag ccatggttcg tggtgtcgat   60
atccttgcag acactgttaa agtaaccttg ggaccaaaag gtcgcaatgt cgttcttgaa   120
aagtcattcg gttcaccctt gattaccaat gacggtgtga ccattgccaa agaaatcgaa   180
ttggaagacc attttgaaaa tatgggtgct aagttagtat cagaagtagc ttctaaaacc   240
aatgatatcg caggtgacgg aactacgact gcaacagtct tgacccaagc tatcgtccgt   300
gaaggaatca aaaacgtcac agcaggtgca aatccaatcg gtattcgtcg tgggattgaa   360
acagcagttg ccgcagcagt tgaagctttg aaaaacaacg ccatccctgt tgccaataaa   420
gaagctatcg ctcaagttgc agccgtatct tctcgttctg aaaaagttgg tgagtacatc   480
tctgaagcaa tggaaaaagt tggcaaagac ggtgtcatca ccatcgaaga gtcacgtggt   540
atggaaacag agcttgaagt cgtagaagga atgcagtttg accgtggtta cctttcacag   600
tacatggtga cagatagcga aaaaatggtg gctgaccttg aaaatccgta cattttgatt   660
acagacaaga aaatttccaa tatccaagaa atcttgccac ttttggaaag cattctccaa   720
agcaatcgtc cactcttgat tattgcggat gatgtggatg gcgaggctct tccaactctt   780
gttttgaaca agattcgtgg aaccttcaac gtagtagcag tcaaggcacc tggttttggt   840
gaccgtcgca aagccatgct tgaagatatc gccatcttaa caggcggaac agttatcaca   900
gaagaccttg gtcttgagtt gaaagatgcg acaattgaag ctcttggtca agcagcgaga   960
gtgaccgtgg acaaagatag cacggttatt gtagaaggtg caggaaatcc tgaagcgatt   1020
tctcaccgtg ttgcggttat caagtctcaa atcgaaacta caacttctga atttgaccgt   1080
gaaaaattgc aagaacgctt ggccaaattg tcaggtggtg tagcggttat taaggttgga   1140
gccgcaactg aaactgagtt gaaagaaatg aaactccgca ttgaagatgc cctcaacgct   1200
actcgtgcag ctgttgaaga aggtattgtt gcaggtggtg gaacagctct tgccaatgtg   1260
attccagctg ttgctacctt ggaattgaca ggagatgaag caacaggacg taatattgtt   1320
ctccgtgctt tggaagaacc cgttcgtcaa attgctcaca atgcaggatt tgaaggatct   1380
atcgttatcg atcgtttgaa aaatgctgag cttggtatag gatttaacgc agcaactggc   1440
gagtgggtta acatgattga tcaaggtatc attgatccag ttaaagtgag tcgttcagcc   1500
ctacaaaatg cagcatctgt agccagcttg attttgacaa cagaagcagt cgtagccaat   1560
aaaccagaac cagtagcccc agctccagca atggatccaa gcatgatggg cgggatgatg   1620

<210>   3964
<211>   540
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   chaperonin, 60 kDa (groEL)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903764 (0.E+01)

<400>   3964
Met Ser Lys Glu Ile Lys Phe Ser Ser Asp Ala Arg Ser Ala Met Val 
1               5                   10                  15      

Arg Gly Val Asp Ile Leu Ala Asp Thr Val Lys Val Thr Leu Gly Pro 
            20                  25                  30          

Lys Gly Arg Asn Val Val Leu Glu Lys Ser Phe Gly Ser Pro Leu Ile 
        35                  40                  45              

Thr Asn Asp Gly Val Thr Ile Ala Lys Glu Ile Glu Leu Glu Asp His 
    50                  55                  60                  

Phe Glu Asn Met Gly Ala Lys Leu Val Ser Glu Val Ala Ser Lys Thr 
65                  70                  75                  80  

Asn Asp Ile Ala Gly Asp Gly Thr Thr Thr Ala Thr Val Leu Thr Gln 
                85                  90                  95      

Ala Ile Val Arg Glu Gly Ile Lys Asn Val Thr Ala Gly Ala Asn Pro 
            100                 105                 110         

Ile Gly Ile Arg Arg Gly Ile Glu Thr Ala Val Ala Ala Ala Val Glu 
        115                 120                 125             

Ala Leu Lys Asn Asn Ala Ile Pro Val Ala Asn Lys Glu Ala Ile Ala 
    130                 135                 140                 

Gln Val Ala Ala Val Ser Ser Arg Ser Glu Lys Val Gly Glu Tyr Ile 
145                 150                 155                 160 

Ser Glu Ala Met Glu Lys Val Gly Lys Asp Gly Val Ile Thr Ile Glu 
                165                 170                 175     

Glu Ser Arg Gly Met Glu Thr Glu Leu Glu Val Val Glu Gly Met Gln 
            180                 185                 190         

Phe Asp Arg Gly Tyr Leu Ser Gln Tyr Met Val Thr Asp Ser Glu Lys 
        195                 200                 205             

Met Val Ala Asp Leu Glu Asn Pro Tyr Ile Leu Ile Thr Asp Lys Lys 
    210                 215                 220                 

Ile Ser Asn Ile Gln Glu Ile Leu Pro Leu Leu Glu Ser Ile Leu Gln 
225                 230                 235                 240 

Ser Asn Arg Pro Leu Leu Ile Ile Ala Asp Asp Val Asp Gly Glu Ala 
                245                 250                 255     

Leu Pro Thr Leu Val Leu Asn Lys Ile Arg Gly Thr Phe Asn Val Val 
            260                 265                 270         

Ala Val Lys Ala Pro Gly Phe Gly Asp Arg Arg Lys Ala Met Leu Glu 
        275                 280                 285             

Asp Ile Ala Ile Leu Thr Gly Gly Thr Val Ile Thr Glu Asp Leu Gly 
    290                 295                 300                 

Leu Glu Leu Lys Asp Ala Thr Ile Glu Ala Leu Gly Gln Ala Ala Arg 
305                 310                 315                 320 

Val Thr Val Asp Lys Asp Ser Thr Val Ile Val Glu Gly Ala Gly Asn 
                325                 330                 335     

Pro Glu Ala Ile Ser His Arg Val Ala Val Ile Lys Ser Gln Ile Glu 
            340                 345                 350         

Thr Thr Thr Ser Glu Phe Asp Arg Glu Lys Leu Gln Glu Arg Leu Ala 
        355                 360                 365             

Lys Leu Ser Gly Gly Val Ala Val Ile Lys Val Gly Ala Ala Thr Glu 
    370                 375                 380                 

Thr Glu Leu Lys Glu Met Lys Leu Arg Ile Glu Asp Ala Leu Asn Ala 
385                 390                 395                 400 

Thr Arg Ala Ala Val Glu Glu Gly Ile Val Ala Gly Gly Gly Thr Ala 
                405                 410                 415     

Leu Ala Asn Val Ile Pro Ala Val Ala Thr Leu Glu Leu Thr Gly Asp 
            420                 425                 430         

Glu Ala Thr Gly Arg Asn Ile Val Leu Arg Ala Leu Glu Glu Pro Val 
        435                 440                 445             

Arg Gln Ile Ala His Asn Ala Gly Phe Glu Gly Ser Ile Val Ile Asp 
    450                 455                 460                 

Arg Leu Lys Asn Ala Glu Leu Gly Ile Gly Phe Asn Ala Ala Thr Gly 
465                 470                 475                 480 

Glu Trp Val Asn Met Ile Asp Gln Gly Ile Ile Asp Pro Val Lys Val 
                485                 490                 495     

Ser Arg Ser Ala Leu Gln Asn Ala Ala Ser Val Ala Ser Leu Ile Leu 
            500                 505                 510         

Thr Thr Glu Ala Val Val Ala Asn Lys Pro Glu Pro Val Ala Pro Ala 
        515                 520                 525             

Pro Ala Met Asp Pro Ser Met Met Gly Gly Met Met 
    530                 535                 540 

<210>   3965
<211>   282
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3965
atgttgaaac cattagggga ccgtgtggtc ttaaaaatag aagaaaaaga acaaactgtt   60
ggaggctttg tccttgcagg ctcagcccaa gaaaaaacca aaacagctca agttgtggct   120
actggacaag gtgttcgtac cttgaacggt gacttggttg ctccaagtgt taaaactgga   180
gatcgtgtct tagttgaagc ccacgcaggt cttgatgtca aagatggcga tgaaaagtac   240
atcatcgtag gcgaagctaa cattttggca atcattgagg aa                      282

<210>   3966
<211>   94
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   chaperonin, 10 kDa (groES)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903765 (1.E-47)

<400>   3966
Met Leu Lys Pro Leu Gly Asp Arg Val Val Leu Lys Ile Glu Glu Lys 
1               5                   10                  15      

Glu Gln Thr Val Gly Gly Phe Val Leu Ala Gly Ser Ala Gln Glu Lys 
            20                  25                  30          

Thr Lys Thr Ala Gln Val Val Ala Thr Gly Gln Gly Val Arg Thr Leu 
        35                  40                  45              

Asn Gly Asp Leu Val Ala Pro Ser Val Lys Thr Gly Asp Arg Val Leu 
    50                  55                  60                  

Val Glu Ala His Ala Gly Leu Asp Val Lys Asp Gly Asp Glu Lys Tyr 
65                  70                  75                  80  

Ile Ile Val Gly Glu Ala Asn Ile Leu Ala Ile Ile Glu Glu 
                85                  90                  

<210>   3967
<211>   393
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3967
atgtataata aagttatctt gattggacgt ttaacgtcta caccagaatt gcacaaaacc   60
aacaatgaca agtcggtagc gcgagcaact atcgctgtga accgtcgtta caaagaccaa   120
aacggtgaac gtgaagctga ttttgtcaat atggtcctat ggggcagact agcagaaact   180
ttggcaagct acgcaaccaa aggtagtctc atttccgttg atggagaatt gcgtacccgt   240
cgctttgaga aaaatggcca aatgaactac gtgaccgaag tacttgtcac aggattccaa   300
ctcttggaaa gtcgtgccca acgtgctatg cgtgaaaata atgcaggcca agatttggca   360
gatttggtct tggaagagga agaattgcca ttt                                393

<210>   3968
<211>   131
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   single-strand binding protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903766 (2.E-70)

<400>   3968
Met Tyr Asn Lys Val Ile Leu Ile Gly Arg Leu Thr Ser Thr Pro Glu 
1               5                   10                  15      

Leu His Lys Thr Asn Asn Asp Lys Ser Val Ala Arg Ala Thr Ile Ala 
            20                  25                  30          

Val Asn Arg Arg Tyr Lys Asp Gln Asn Gly Glu Arg Glu Ala Asp Phe 
        35                  40                  45              

Val Asn Met Val Leu Trp Gly Arg Leu Ala Glu Thr Leu Ala Ser Tyr 
    50                  55                  60                  

Ala Thr Lys Gly Ser Leu Ile Ser Val Asp Gly Glu Leu Arg Thr Arg 
65                  70                  75                  80  

Arg Phe Glu Lys Asn Gly Gln Met Asn Tyr Val Thr Glu Val Leu Val 
                85                  90                  95      

Thr Gly Phe Gln Leu Leu Glu Ser Arg Ala Gln Arg Ala Met Arg Glu 
            100                 105                 110         

Asn Asn Ala Gly Gln Asp Leu Ala Asp Leu Val Leu Glu Glu Glu Glu 
        115                 120                 125             

Leu Pro Phe 
    130     

<210>   3969
<211>   759
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3969
atggcaaaaa atgttgtgat tacaggagcg acatcaggaa tcggtgaagc gattgcgcgt   60
gcttatctgg agcagggtga ggatgtcgtt ctaacaggac gacggataga cagactagaa   120
gctcttaagg cggagtttgc agaaactttt ccaaatcaaa cagtttggac ttttctccta   180
gatgtcacgg atatgacaat ggtaaagact gtctgctctg atattttaga aacgataggt   240
cagattgaca tcctggtcaa taacgcagga ctggctcttg gcttagctcc ctatcaagac   300
tatgaagagt tggatatgct gaccatgttg gataccaatg tcaaaggttt gatggcagtc   360
actcgctgtt tcttgccagc aatggtaaaa gccaatcaag gtcatattat caatatgggg   420
tcaaccgcag gaatttatgc ctatgctggt gcagctgttt actcagccac caaggcggca   480
gttaagacct tttcagatgg actgcgaatt gataccatcg caacggatat caaggtgacg   540
accattcagc ctggaattgt cgaaacagat ttttctacag tgcgttttca tggtgataaa   600
gaacgagctg cgtccgttta ccaaggaata gaagctttgc aagctcagga tattgcagat   660
acagtagtct atgtgactag tcaacctcgt cgtgttcaga ttacagatat gaccattatg   720
gccaatcaac aggcgacagg tttcatggtt cataaaaaa                          759

<210>   3970
<211>   253
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   oxidoreductase, short chain dehydrogenase/reductase family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903767 (e-134)

<400>   3970
Met Ala Lys Asn Val Val Ile Thr Gly Ala Thr Ser Gly Ile Gly Glu 
1               5                   10                  15      

Ala Ile Ala Arg Ala Tyr Leu Glu Gln Gly Glu Asp Val Val Leu Thr 
            20                  25                  30          

Gly Arg Arg Ile Asp Arg Leu Glu Ala Leu Lys Ala Glu Phe Ala Glu 
        35                  40                  45              

Thr Phe Pro Asn Gln Thr Val Trp Thr Phe Leu Leu Asp Val Thr Asp 
    50                  55                  60                  

Met Thr Met Val Lys Thr Val Cys Ser Asp Ile Leu Glu Thr Ile Gly 
65                  70                  75                  80  

Gln Ile Asp Ile Leu Val Asn Asn Ala Gly Leu Ala Leu Gly Leu Ala 
                85                  90                  95      

Pro Tyr Gln Asp Tyr Glu Glu Leu Asp Met Leu Thr Met Leu Asp Thr 
            100                 105                 110         

Asn Val Lys Gly Leu Met Ala Val Thr Arg Cys Phe Leu Pro Ala Met 
        115                 120                 125             

Val Lys Ala Asn Gln Gly His Ile Ile Asn Met Gly Ser Thr Ala Gly 
    130                 135                 140                 

Ile Tyr Ala Tyr Ala Gly Ala Ala Val Tyr Ser Ala Thr Lys Ala Ala 
145                 150                 155                 160 

Val Lys Thr Phe Ser Asp Gly Leu Arg Ile Asp Thr Ile Ala Thr Asp 
                165                 170                 175     

Ile Lys Val Thr Thr Ile Gln Pro Gly Ile Val Glu Thr Asp Phe Ser 
            180                 185                 190         

Thr Val Arg Phe His Gly Asp Lys Glu Arg Ala Ala Ser Val Tyr Gln 
        195                 200                 205             

Gly Ile Glu Ala Leu Gln Ala Gln Asp Ile Ala Asp Thr Val Val Tyr 
    210                 215                 220                 

Val Thr Ser Gln Pro Arg Arg Val Gln Ile Thr Asp Met Thr Ile Met 
225                 230                 235                 240 

Ala Asn Gln Gln Ala Thr Gly Phe Met Val His Lys Lys 
                245                 250             

<210>   3971
<211>   624
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3971
atgattttta catataataa agaacatgtc ggtgatgtcc ttatggtcat cgtgaaaaat   60
agcggagatg ccaaactgga tgtggagcgc aaaggcaagg tagcccgtgt ttttctcaaa   120
gataatgggg aaacagtggc ttggaatatt ttcgaagttt caagtttatt tgaaattgca   180
gagcgcggtc aagtcttttt gacagatgag caagtcgctc gtttgaacca agagttgcag   240
gcggaaggtt ttacagaaga aattgttaat gataaggaac ctaagtttgt tgtaggtgaa   300
attgttgaga tggtagccca tccagatagt gaccacctca acatctgcca agttgcagtc   360
gcaagtgata agactgtaca aatcgttgca ggagctccca atgcgcgtgt ggggttgaaa   420
accattgtcg cgcttcctgg agctatgatg ccaaaaggga atctcatttt cccaggtgaa   480
cttcgtggtg aaaagagttt tggtatgatg tgcagtcctc gtgaattgca tctgccaaat   540
gctccacaaa aacgtggggt gcttgaatta tcagaagacc aagttgtcgg aacaccgttc   600
gacccagcga aacactggac tgcc                                          624

<210>   3972
<211>   208
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903768 (e-115)

<400>   3972
Met Ile Phe Thr Tyr Asn Lys Glu His Val Gly Asp Val Leu Met Val 
1               5                   10                  15      

Ile Val Lys Asn Ser Gly Asp Ala Lys Leu Asp Val Glu Arg Lys Gly 
            20                  25                  30          

Lys Val Ala Arg Val Phe Leu Lys Asp Asn Gly Glu Thr Val Ala Trp 
        35                  40                  45              

Asn Ile Phe Glu Val Ser Ser Leu Phe Glu Ile Ala Glu Arg Gly Gln 
    50                  55                  60                  

Val Phe Leu Thr Asp Glu Gln Val Ala Arg Leu Asn Gln Glu Leu Gln 
65                  70                  75                  80  

Ala Glu Gly Phe Thr Glu Glu Ile Val Asn Asp Lys Glu Pro Lys Phe 
                85                  90                  95      

Val Val Gly Glu Ile Val Glu Met Val Ala His Pro Asp Ser Asp His 
            100                 105                 110         

Leu Asn Ile Cys Gln Val Ala Val Ala Ser Asp Lys Thr Val Gln Ile 
        115                 120                 125             

Val Ala Gly Ala Pro Asn Ala Arg Val Gly Leu Lys Thr Ile Val Ala 
    130                 135                 140                 

Leu Pro Gly Ala Met Met Pro Lys Gly Asn Leu Ile Phe Pro Gly Glu 
145                 150                 155                 160 

Leu Arg Gly Glu Lys Ser Phe Gly Met Met Cys Ser Pro Arg Glu Leu 
                165                 170                 175     

His Leu Pro Asn Ala Pro Gln Lys Arg Gly Val Leu Glu Leu Ser Glu 
            180                 185                 190         

Asp Gln Val Val Gly Thr Pro Phe Asp Pro Ala Lys His Trp Thr Ala 
        195                 200                 205             


<210>   3973
<211>   315
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3973
atgatacagc cagcaagttt agaagaatta gcatctttag tggaaaaagc gggcaagaag   60
gtcttcattt ttgtggcaga ctggtgtagc gattgtcgtt atatttatcc tgccttacca   120
gagattgagg agaccaatcc agagttcacc tttattcgaa tggaccgaga tcagtatatg   180
gatttggcca aactctggga tgtttacgga attcctagcc ttgttgttct agaaaaggac   240
aaggaaatcg gtcgttttgt caatcgcgac cgtaaaagca agcaacaaat caatgacttt   300
ttagcaggac tgaaa                                                    315

<210>   3974
<211>   105
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   thioredoxin, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903769 (5.E-57)

<400>   3974
Met Ile Gln Pro Ala Ser Leu Glu Glu Leu Ala Ser Leu Val Glu Lys 
1               5                   10                  15      

Ala Gly Lys Lys Val Phe Ile Phe Val Ala Asp Trp Cys Ser Asp Cys 
            20                  25                  30          

Arg Tyr Ile Tyr Pro Ala Leu Pro Glu Ile Glu Glu Thr Asn Pro Glu 
        35                  40                  45              

Phe Thr Phe Ile Arg Met Asp Arg Asp Gln Tyr Met Asp Leu Ala Lys 
    50                  55                  60                  

Leu Trp Asp Val Tyr Gly Ile Pro Ser Leu Val Val Leu Glu Lys Asp 
65                  70                  75                  80  

Lys Glu Ile Gly Arg Phe Val Asn Arg Asp Arg Lys Ser Lys Gln Gln 
                85                  90                  95      

Ile Asn Asp Phe Leu Ala Gly Leu Lys 
            100                 105 

<210>   3975
<211>   297
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3975
atgaatggta tgaaagctaa aaaaatgtgg atggcaggct tggctctgct aggtatcgga   60
agccttgctc ttgctacgaa aaaagttgca gatgaccgta agctcatgaa gactcaggaa   120
gagttgacag agattgtgcg agaccatttt tccgacatgg gggaaattgc gaccctttat   180
gttcaagttt acgaaagcag tctggagagc ttggttggtg gcgtcatttt tgaggatggc   240
cgtcattata cctttgtcta tgaaaatgaa gacctagtct atgaggagga agtctta      297

<210>   3976
<211>   99
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903770 (2.E-52)

<400>   3976
Met Asn Gly Met Lys Ala Lys Lys Met Trp Met Ala Gly Leu Ala Leu 

1               5                   10                  15      

Leu Gly Ile Gly Ser Leu Ala Leu Ala Thr Lys Lys Val Ala Asp Asp 
            20                  25                  30          

Arg Lys Leu Met Lys Thr Gln Glu Glu Leu Thr Glu Ile Val Arg Asp 
        35                  40                  45              

His Phe Ser Asp Met Gly Glu Ile Ala Thr Leu Tyr Val Gln Val Tyr 
    50                  55                  60                  

Glu Ser Ser Leu Glu Ser Leu Val Gly Gly Val Ile Phe Glu Asp Gly 
65                  70                  75                  80  

Arg His Tyr Thr Phe Val Tyr Glu Asn Glu Asp Leu Val Tyr Glu Glu 
                85                  90                  95      

Glu Val Leu 
            


<210>   3977
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3977
atgaaaatca aagaccaaac taggaagcta gccgcaggct gctcaaagca ctgctttgag   60
gttgtagata gaactgacga agtcagctca aaacactgtt ttgaggttgt ggatgaagct   120
gacgtggtt                                                           129

<210>   3978
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   3978
Met Lys Ile Lys Asp Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Cys Phe Glu Val Val Asp Glu Ala Asp Val Val 
        35                  40              

<210>   3979
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3979
gtgcctggca ataagaataa tactcttcga aaatctcttc aaaccacgtc agcttcatcc   60
acaacctcaa aacagtgttt tgagctgact tcgtcagttc tatctacaac ctcaaagcag   120
tgctttgagc agcctgcggc tagcttccta gtttggtctt tgattttcat tgagtataag   180
aagtcctttt ccttaaagga agaggctttt tacttgcttt tctgctgctt cctcatttgt   240
cctgaagcct tttttgtgtt aaaa                                          264

<210>   3980
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   3980
Met Pro Gly Asn Lys Asn Asn Thr Leu Arg Lys Ser Leu Gln Thr Thr 
1               5                   10                  15      

Ser Ala Ser Ser Thr Thr Ser Lys Gln Cys Phe Glu Leu Thr Ser Ser 
            20                  25                  30          

Val Leu Ser Thr Thr Ser Lys Gln Cys Phe Glu Gln Pro Ala Ala Ser 
        35                  40                  45              

Phe Leu Val Trp Ser Leu Ile Phe Ile Glu Tyr Lys Lys Ser Phe Ser 
    50                  55                  60                  

Leu Lys Glu Glu Ala Phe Tyr Leu Leu Phe Cys Cys Phe Leu Ile Cys 
65                  70                  75                  80  

Pro Glu Ala Phe Phe Val Leu Lys 
                85              

<210>   3981
<211>   213
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3981
ttggctttta cgtttgatgt atctatgtac tacagcgtag atgatgtagt gtcaaatgct   60
tttaaaaaac gaatgatatt ggacagtttt tttgccttta attgctcagg aaccatgaaa   120
gtcagtactt gggtttatga caagggagaa tggtattatg taagttcttc tggttccatg   180
attgcgaatg attgggtcaa agacaatggc aag                                213

<210>   3982
<211>   71
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cspC-related protein POINT MUTATION

<400>   3982
Met Ala Phe Thr Phe Asp Val Ser Met Tyr Tyr Ser Val Asp Asp Val 
1               5                   10                  15      

Val Ser Asn Ala Phe Lys Lys Arg Met Ile Leu Asp Ser Phe Phe Ala 
            20                  25                  30          

Phe Asn Cys Ser Gly Thr Met Lys Val Ser Thr Trp Val Tyr Asp Lys 
        35                  40                  45              

Gly Glu Trp Tyr Tyr Val Ser Ser Ser Gly Ser Met Ile Ala Asn Asp 
    50                  55                  60                  

Trp Val Lys Asp Asn Gly Lys 
65                  70      

<210>   3983
<211>   672
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3983
atgaaaaaga aagcatttgg tattgtttta ttggttttag cagcttggat cttgctgcaa   60
gggaattttg gaattccttc tttggatggt aaaatatggc ctttactagg tattgttttt   120
tttgcttata agtccattga gtccatcctt agacgtcatc tcacttcggc agtttttaca   180
ggtttactgg cgctcatcat tgcaaattac gcttatgact tgttaccagt taccaatcat   240
tctcttattt gggctagcat cttggtggta cttggtgttg gttatctgac gcattcaagt   300
aagttctgga atgaaaaaaa atggtggtac aatgggaaaa aaacagtcgt cacggataag   360
gaagtcgctt ttggtagcgg gaccttctat aagcaagatc aagatctcgt agatgaccaa   420
gtggaagtcg cttttgggga tgctaaaatc tactatgata atgcagagat gctaggtgat   480
tttgcaactt taaatattga agtggccttc gggaatgcaa ccgtctatgt tccacaacac   540
tggcgtgtag atttgaaagt agaaacctcc tttggtgcag ctaaggctga cgctcctgta   600
gccccaacca gcaaaacctt gattatccgt ggagatgtgg cttttgggaa gttggaaatt   660
gtctacgtta aa                                                       672

<210>   3984
<211>   224
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15903772 (e-128)

<400>   3984
Met Lys Lys Lys Ala Phe Gly Ile Val Leu Leu Val Leu Ala Ala Trp 
1               5                   10                  15      

Ile Leu Leu Gln Gly Asn Phe Gly Ile Pro Ser Leu Asp Gly Lys Ile 
            20                  25                  30          

Trp Pro Leu Leu Gly Ile Val Phe Phe Ala Tyr Lys Ser Ile Glu Ser 
        35                  40                  45              

Ile Leu Arg Arg His Leu Thr Ser Ala Val Phe Thr Gly Leu Leu Ala 
    50                  55                  60                  

Leu Ile Ile Ala Asn Tyr Ala Tyr Asp Leu Leu Pro Val Thr Asn His 
65                  70                  75                  80  

Ser Leu Ile Trp Ala Ser Ile Leu Val Val Leu Gly Val Gly Tyr Leu 
                85                  90                  95      

Thr His Ser Ser Lys Phe Trp Asn Glu Lys Lys Trp Trp Tyr Asn Gly 
            100                 105                 110         

Lys Lys Thr Val Val Thr Asp Lys Glu Val Ala Phe Gly Ser Gly Thr 
        115                 120                 125             

Phe Tyr Lys Gln Asp Gln Asp Leu Val Asp Asp Gln Val Glu Val Ala 
    130                 135                 140                 

Phe Gly Asp Ala Lys Ile Tyr Tyr Asp Asn Ala Glu Met Leu Gly Asp 
145                 150                 155                 160 

Phe Ala Thr Leu Asn Ile Glu Val Ala Phe Gly Asn Ala Thr Val Tyr 
                165                 170                 175     

Val Pro Gln His Trp Arg Val Asp Leu Lys Val Glu Thr Ser Phe Gly 
            180                 185                 190         

Ala Ala Lys Ala Asp Ala Pro Val Ala Pro Thr Ser Lys Thr Leu Ile 
        195                 200                 205             

Ile Arg Gly Asp Val Ala Phe Gly Lys Leu Glu Ile Val Tyr Val Lys 
    210                 215                 220                 


<210>   3985
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3985
gtgatgaagt tacgaattga gattgacggc aatttagagg agactgaaat tgtcatcaag   60
acccccactt tgacagatga aattgcagac ttgcaacgcc tcttgcaaga gtcaaaggct   120
ccgaggttga ctttttacaa ggggacaggt gaatattatc tagacctgtc agaaattctc   180
ttctttgaaa cagaagggag caagatctac gctcataacc agaaggaagc ttatgaggtt   240
cgcctcaagc tctatgagtt ggagtctatc ttgcctcgct attttaatcg agtttccaag   300
tcaacgatcg caaacatccg tcagatttac tcagtggaca agtccttttc aggaacgggc   360
accatttcct tttatcagac gcacaaggag gttcatgtct cacggcatta ccaatccctc   420
ctaaaagaaa atctaagaaa catgagg                                       447

<210>   3986
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903773 (2.E-80)

<400>   3986
Met Met Lys Leu Arg Ile Glu Ile Asp Gly Asn Leu Glu Glu Thr Glu 
1               5                   10                  15      

Ile Val Ile Lys Thr Pro Thr Leu Thr Asp Glu Ile Ala Asp Leu Gln 
            20                  25                  30          

Arg Leu Leu Gln Glu Ser Lys Ala Pro Arg Leu Thr Phe Tyr Lys Gly 
        35                  40                  45              

Thr Gly Glu Tyr Tyr Leu Asp Leu Ser Glu Ile Leu Phe Phe Glu Thr 
    50                  55                  60                  

Glu Gly Ser Lys Ile Tyr Ala His Asn Gln Lys Glu Ala Tyr Glu Val 
65                  70                  75                  80  

Arg Leu Lys Leu Tyr Glu Leu Glu Ser Ile Leu Pro Arg Tyr Phe Asn 
                85                  90                  95      

Arg Val Ser Lys Ser Thr Ile Ala Asn Ile Arg Gln Ile Tyr Ser Val 
            100                 105                 110         

Asp Lys Ser Phe Ser Gly Thr Gly Thr Ile Ser Phe Tyr Gln Thr His 
        115                 120                 125             

Lys Glu Val His Val Ser Arg His Tyr Gln Ser Leu Leu Lys Glu Asn 
    130                 135                 140                 

Leu Arg Asn Met Arg 
145                 

<210>   3987
<211>   501
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3987
atgaaaaatt atcaagaatg gtatcgaaat atcagctcca gactaactag ttgtccaatt   60
cttttattcc tattacgcag tttcaatcgt ttgatgacag tcgccatgcc cctggtctat   120
ctgatcttgc tagtcaccac ttacctgcaa ctaggacttg gtcagcaagt tggggtttat   180
gtgcttattc ctgcatcagg ttttgtggcc ttgtccctgt ttcgtaagaa aatcaatcac   240
ccgagacctt atgaaacttg ggatatctgt ccccttcttg ataaggatag ttcgggacgg   300
tcgatgccca gtcgccatgt cttttcggca actatcatct ccatggcctg tctgcatgct   360
agtctaccta ttggcttagt atgcttgatc ttttcagctt tgctggggtt ggtgagggtt   420
ttagggggtg ttcattatcc caaggatgtc ttggttggct atgcttgtgg tttggtgtgg   480
ggattccttt tcttcctatt c                                             501

<210>   3988
<211>   167
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PAP2 family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903774 (8.E-93)

<400>   3988
Met Lys Asn Tyr Gln Glu Trp Tyr Arg Asn Ile Ser Ser Arg Leu Thr 
1               5                   10                  15      

Ser Cys Pro Ile Leu Leu Phe Leu Leu Arg Ser Phe Asn Arg Leu Met 
            20                  25                  30          

Thr Val Ala Met Pro Leu Val Tyr Leu Ile Leu Leu Val Thr Thr Tyr 
        35                  40                  45              

Leu Gln Leu Gly Leu Gly Gln Gln Val Gly Val Tyr Val Leu Ile Pro 
    50                  55                  60                  

Ala Ser Gly Phe Val Ala Leu Ser Leu Phe Arg Lys Lys Ile Asn His 
65                  70                  75                  80  

Pro Arg Pro Tyr Glu Thr Trp Asp Ile Cys Pro Leu Leu Asp Lys Asp 
                85                  90                  95      

Ser Ser Gly Arg Ser Met Pro Ser Arg His Val Phe Ser Ala Thr Ile 
            100                 105                 110         

Ile Ser Met Ala Cys Leu His Ala Ser Leu Pro Ile Gly Leu Val Cys 
        115                 120                 125             

Leu Ile Phe Ser Ala Leu Leu Gly Leu Val Arg Val Leu Gly Gly Val 
    130                 135                 140                 

His Tyr Pro Lys Asp Val Leu Val Gly Tyr Ala Cys Gly Leu Val Trp 
145                 150                 155                 160 

Gly Phe Leu Phe Phe Leu Phe 
                165         

<210>   3989
<211>   360
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3989
atgagtcaga aattatacaa tatgaaattt gctgctgtct acttagcctt gattgcaaaa   60
gttgagcgaa agggtggaaa ggcagagtca gttcaccaag tgaccagttg gttgacaggg   120
tatgaagtga gtgatgttct tgcttgtctg gatagggatg ttacttacgg agattttttt   180
agacaagcac catattatgt ccctgaacga attgcaatta cagggaagat ttgcggtgtc   240
cgtattgagg aaattgatga tcctctgatg caggaaatac gtcgcttgga caagctagtg   300
gattggcttg ccaaggggaa aacatctcaa caagttctag aaaagtatga gaagcataaa   360

<210>   3990
<211>   120
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903775 (1.E-66)

<400>   3990
Met Ser Gln Lys Leu Tyr Asn Met Lys Phe Ala Ala Val Tyr Leu Ala 
1               5                   10                  15      

Leu Ile Ala Lys Val Glu Arg Lys Gly Gly Lys Ala Glu Ser Val His 
            20                  25                  30          

Gln Val Thr Ser Trp Leu Thr Gly Tyr Glu Val Ser Asp Val Leu Ala 
        35                  40                  45              

Cys Leu Asp Arg Asp Val Thr Tyr Gly Asp Phe Phe Arg Gln Ala Pro 
    50                  55                  60                  

Tyr Tyr Val Pro Glu Arg Ile Ala Ile Thr Gly Lys Ile Cys Gly Val 
65                  70                  75                  80  

Arg Ile Glu Glu Ile Asp Asp Pro Leu Met Gln Glu Ile Arg Arg Leu 
                85                  90                  95      

Asp Lys Leu Val Asp Trp Leu Ala Lys Gly Lys Thr Ser Gln Gln Val 
            100                 105                 110         

Leu Glu Lys Tyr Glu Lys His Lys 
        115                 120 

<210>   3991
<211>   1029
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   3991
atgggcttcc ttctcatggg agcactcttc atcgttcttc cccgaactat ggtctctgct   60
aagcggatta atcaagtttt agatttgcat tcttctatcc aaaaccctgt tcaagtgcag   120
ctgactgatg aaaacttcaa aggtcaggtc gagtttaagg atgtgacctt ccgctatgcg   180
gcaaattcgg aggcagttat tgaacatgtt agctttaaag cagaaactgg tcaaacagtg   240
gcctttattg ggtcaacagg ttctggtaaa tcaactctgg tcaatctgat tccacgtttc   300
tacgacgtgt cagcaggaga aattctggtg gacggtgtca atgttcaaga ctatgacttc   360
tctgcgacag ctcatgctgg tcaaaaggtt gccattgttg ggccgactgg ggctggtaag   420
acaaccattg tcaatctttt gatgaaattc tatgagattg ataagggaag tattcgcatt   480
gatggtgtgg ataccaaggc tatgacgcgt tcagaagtgc atgatgcctt ttcaatggtc   540
ttgcaggata cctggctctt tgaaggaact attcgagaca atctcatcta taatcaaata   600
gggattagtg atgaacgaat gatggaagct agtaaggctg tgggaattca ccactttatt   660
atgaccttgc cagatggcta tgataccatc ttggatgaca ccgtgacctt gtctgtaaga   720
caaaaacaac tattgactat tgctcgtgcc cttcttaagg atgcaccgct tttgattttg   780
gatgaggcga cttcttctgt tgacacacgg acagaggaat tgatccaaaa agccatggac   840
cgtttgatgg aaggacgcac atcctttgtc attgcccacc gcttgtcaac catccgaaat   900
gcagacttga tcttggtcat gaaagatgga aatatcatcg agcaaggcaa ctatgaggaa   960
ctgatggcgc aaggtggctt ctacgctgac ttgtacaata gtcaatttac agaagatgaa   1020
gcagaagaa                                                           1029

<210>   3992
<211>   343
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903776 (0.E+01)

<400>   3992
Met Gly Phe Leu Leu Met Gly Ala Leu Phe Ile Val Leu Pro Arg Thr 
1               5                   10                  15      

Met Val Ser Ala Lys Arg Ile Asn Gln Val Leu Asp Leu His Ser Ser 
            20                  25                  30          

Ile Gln Asn Pro Val Gln Val Gln Leu Thr Asp Glu Asn Phe Lys Gly 
        35                  40                  45              

Gln Val Glu Phe Lys Asp Val Thr Phe Arg Tyr Ala Ala Asn Ser Glu 
    50                  55                  60                  

Ala Val Ile Glu His Val Ser Phe Lys Ala Glu Thr Gly Gln Thr Val 
65                  70                  75                  80  

Ala Phe Ile Gly Ser Thr Gly Ser Gly Lys Ser Thr Leu Val Asn Leu 
                85                  90                  95      

Ile Pro Arg Phe Tyr Asp Val Ser Ala Gly Glu Ile Leu Val Asp Gly 
            100                 105                 110         

Val Asn Val Gln Asp Tyr Asp Phe Ser Ala Thr Ala His Ala Gly Gln 
        115                 120                 125             

Lys Val Ala Ile Val Gly Pro Thr Gly Ala Gly Lys Thr Thr Ile Val 
    130                 135                 140                 

Asn Leu Leu Met Lys Phe Tyr Glu Ile Asp Lys Gly Ser Ile Arg Ile 
145                 150                 155                 160 


Asp Gly Val Asp Thr Lys Ala Met Thr Arg Ser Glu Val His Asp Ala 
                165                 170                 175     

Phe Ser Met Val Leu Gln Asp Thr Trp Leu Phe Glu Gly Thr Ile Arg 
            180                 185                 190         

Asp Asn Leu Ile Tyr Asn Gln Ile Gly Ile Ser Asp Glu Arg Met Met 
        195                 200                 205             

Glu Ala Ser Lys Ala Val Gly Ile His His Phe Ile Met Thr Leu Pro 
    210                 215                 220                 

Asp Gly Tyr Asp Thr Ile Leu Asp Asp Thr Val Thr Leu Ser Val Arg 
225                 230                 235                 240 

Gln Lys Gln Leu Leu Thr Ile Ala Arg Ala Leu Leu Lys Asp Ala Pro 
                245                 250                 255     

Leu Leu Ile Leu Asp Glu Ala Thr Ser Ser Val Asp Thr Arg Thr Glu 
            260                 265                 270         

Glu Leu Ile Gln Lys Ala Met Asp Arg Leu Met Glu Gly Arg Thr Ser 
        275                 280                 285             

Phe Val Ile Ala His Arg Leu Ser Thr Ile Arg Asn Ala Asp Leu Ile 
    290                 295                 300                 

Leu Val Met Lys Asp Gly Asn Ile Ile Glu Gln Gly Asn Tyr Glu Glu 
305                 310                 315                 320 

Leu Met Ala Gln Gly Gly Phe Tyr Ala Asp Leu Tyr Asn Ser Gln Phe 
                325                 330                 335     

Thr Glu Asp Glu Ala Glu Glu 
            340             


<210>   3993
<211>   819
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3993
atgattttac tagccattct ctttacttgc ttttcggtct atctagagtt ggaagtgccg   60
acctatatct cgaaaattac ggatttgcta ggtagtcaag aaactaattt agatgagttg   120
tggcagtcgg caagcatgat gatgggaatg tcctttcttg ccttcttgtc cgtagttgca   180
gttggatttt ttgcatcccg agtggcggct tcttatacta gtaggctgag aagtgatatt   240
tttaaccgag ttttggatta ctcgcagaca gagattaaga aattttcaat tcctagcctc   300
ttgacgcgta ctaccaatga cattactcaa gttcaaatgt tgattactat gggcttgcaa   360
gtggtaacgc gtggttcaat tatggctatc tgggctattg ggaagatttt aggtcattca   420
gaatactggc tctgggccgt acttgtggca gtgattatca acgtcctgat gacgaccgtt   480
ttgatgacgc tagcctttcc aaaacagtcc ttgattcagg ggctgacaga taaactgaac   540
agtatcactc gtgagagttt aacaggtatt cgtgtcgttc gtgcctacaa tgcagaggat   600
tatcaaaatg aaaaatttgc agcagtaaat gatgaattga cccgtttgaa tttgtttgtc   660
aaccgtctta tggctatttt gaatcctatc atgatgggga tttcaagtgg tttgagtgtg   720
gcgatttact ggattggggc ctatgtgatt aacgacgctg ctccgatagc gcgtctgcct   780
ctctttagtg acatgattgt tttcatgtct tatgccatg                          819

<210>   3994
<211>   273
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903778 (e-112)

<400>   3994
Met Ile Leu Leu Ala Ile Leu Phe Thr Cys Phe Ser Val Tyr Leu Glu 
1               5                   10                  15      

Leu Glu Val Pro Thr Tyr Ile Ser Lys Ile Thr Asp Leu Leu Gly Ser 
            20                  25                  30          

Gln Glu Thr Asn Leu Asp Glu Leu Trp Gln Ser Ala Ser Met Met Met 
        35                  40                  45              

Gly Met Ser Phe Leu Ala Phe Leu Ser Val Val Ala Val Gly Phe Phe 
    50                  55                  60                  

Ala Ser Arg Val Ala Ala Ser Tyr Thr Ser Arg Leu Arg Ser Asp Ile 
65                  70                  75                  80  

Phe Asn Arg Val Leu Asp Tyr Ser Gln Thr Glu Ile Lys Lys Phe Ser 
                85                  90                  95      

Ile Pro Ser Leu Leu Thr Arg Thr Thr Asn Asp Ile Thr Gln Val Gln 
            100                 105                 110         

Met Leu Ile Thr Met Gly Leu Gln Val Val Thr Arg Gly Ser Ile Met 
        115                 120                 125             

Ala Ile Trp Ala Ile Gly Lys Ile Leu Gly His Ser Glu Tyr Trp Leu 
    130                 135                 140                 

Trp Ala Val Leu Val Ala Val Ile Ile Asn Val Leu Met Thr Thr Val 
145                 150                 155                 160 

Leu Met Thr Leu Ala Phe Pro Lys Gln Ser Leu Ile Gln Gly Leu Thr 
                165                 170                 175     

Asp Lys Leu Asn Ser Ile Thr Arg Glu Ser Leu Thr Gly Ile Arg Val 
            180                 185                 190         

Val Arg Ala Tyr Asn Ala Glu Asp Tyr Gln Asn Glu Lys Phe Ala Ala 
        195                 200                 205             

Val Asn Asp Glu Leu Thr Arg Leu Asn Leu Phe Val Asn Arg Leu Met 
    210                 215                 220                 

Ala Ile Leu Asn Pro Ile Met Met Gly Ile Ser Ser Gly Leu Ser Val 
225                 230                 235                 240 

Ala Ile Tyr Trp Ile Gly Ala Tyr Val Ile Asn Asp Ala Ala Pro Ile 
                245                 250                 255     

Ala Arg Leu Pro Leu Phe Ser Asp Met Ile Val Phe Met Ser Tyr Ala 
            260                 265                 270         

Met 
    

<210>   3995
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3995
atggataaac cgatgttagt ctttaagcgt tttggtcatc aaattcacct gatggtgcaa   60
aaggaagcca aacgttgcgg cattgaattt atgggtgggc cgcaaggtca ggttgtgcgt   120
tttttggata atcgcgagaa aaaccaagac ttggtcttga ttaaagatat cgagcaggaa   180
ctcaatatta ccaagcctgt tgctagtaat ctggttaagc gtatagtgca aaatggtttg   240
gtggaattgg aggcgagtcc tgttgataag cgggctaagt ttgttcgtct gacggacaaa   300
gcacgttctc agatgcaaca ggttaaggct ttttttgaac gcatagacaa gcagttgatg   360
gaagacattg atgaagatga attactgatt tttgagaagg ttctcggtca actacaggca   420
aaatatcaag ggaataggag gagagaa                                       447

<210>   3996
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, MarR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903779 (1.E-57)

<400>   3996
Met Asp Lys Pro Met Leu Val Phe Lys Arg Phe Gly His Gln Ile His 
1               5                   10                  15      

Leu Met Val Gln Lys Glu Ala Lys Arg Cys Gly Ile Glu Phe Met Gly 
            20                  25                  30          

Gly Pro Gln Gly Gln Val Val Arg Phe Leu Asp Asn Arg Glu Lys Asn 
        35                  40                  45              

Gln Asp Leu Val Leu Ile Lys Asp Ile Glu Gln Glu Leu Asn Ile Thr 
    50                  55                  60                  

Lys Pro Val Ala Ser Asn Leu Val Lys Arg Ile Val Gln Asn Gly Leu 
65                  70                  75                  80  

Val Glu Leu Glu Ala Ser Pro Val Asp Lys Arg Ala Lys Phe Val Arg 
                85                  90                  95      

Leu Thr Asp Lys Ala Arg Ser Gln Met Gln Gln Val Lys Ala Phe Phe 
            100                 105                 110         

Glu Arg Ile Asp Lys Gln Leu Met Glu Asp Ile Asp Glu Asp Glu Leu 
        115                 120                 125             

Leu Ile Phe Glu Lys Val Leu Gly Gln Leu Gln Ala Lys Tyr Gln Gly 
    130                 135                 140                 

Asn Arg Arg Arg Glu 
145                 

<210>   3997
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3997
atgatcctaa gtgagaaaat cacttgggat ttttttaatc aagaaaatag ttctcataga   60
aatttaatta ttctccagag aactattttt att                                93

<210>   3998
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   3998
Met Ile Leu Ser Glu Lys Ile Thr Trp Asp Phe Phe Asn Gln Glu Asn 
1               5                   10                  15      

Ser Ser His Arg Asn Leu Ile Ile Leu Gln Arg Thr Ile Phe Ile 
            20                  25                  30      

<210>   3999
<211>   714
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   3999
atgggacgta aatgggccaa tatcgtagcc aagaaaacgg ctaaagatgg agctaactct   60
aaagtatatg caaaatttgg tgtagaaatc tatgtagcag ctaaaaaagg tgatccagat   120
ccagaatcaa actcagcttt gaaattcgtt atcgaccgtg ctaaacaagc ccaagtgcca   180
aaacacatta tcgataaagc gattgataaa gccaaaggaa acacagacga aacctttaca   240
gaaggacgtt acgaaggttt tgggccaaat ggctctatgc taattgtgga tactttgact   300
tctaacgtca accgtacagc agccaatgtc cgtgcagcct ttggtaaaaa cggcggaaac   360
atgggcgctt caggttctgt ttcttacctc tttgacaaca aaggtgttat tgtatttgga   420
ggtgaagatg cggacgcagt ctttgagcaa ttgctcgaag cggatgtgga tgtggatgac   480
gtagaagcac aagaaggtac aatcacagtt tacacagcgc caactgacct tcacaaggct   540
atcgttgccc tccgtgagtc tggtattgaa gaattccaag tgactgaatt ggaaatgatt   600
cctcagtcag aagtggaatt gtcaggcgaa gaccttgaaa cctttgaaaa actttacagc   660
gttcttgaag acgacgaaga cgtccaaaag atttatacga acgtagatgg gttt         714

<210>   4000
<211>   238
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903780 (e-134)

<400>   4000
Met Gly Arg Lys Trp Ala Asn Ile Val Ala Lys Lys Thr Ala Lys Asp 
1               5                   10                  15      

Gly Ala Asn Ser Lys Val Tyr Ala Lys Phe Gly Val Glu Ile Tyr Val 
            20                  25                  30          

Ala Ala Lys Lys Gly Asp Pro Asp Pro Glu Ser Asn Ser Ala Leu Lys 
        35                  40                  45              

Phe Val Ile Asp Arg Ala Lys Gln Ala Gln Val Pro Lys His Ile Ile 
    50                  55                  60                  

Asp Lys Ala Ile Asp Lys Ala Lys Gly Asn Thr Asp Glu Thr Phe Thr 
65                  70                  75                  80  

Glu Gly Arg Tyr Glu Gly Phe Gly Pro Asn Gly Ser Met Leu Ile Val 
                85                  90                  95      

Asp Thr Leu Thr Ser Asn Val Asn Arg Thr Ala Ala Asn Val Arg Ala 
            100                 105                 110         

Ala Phe Gly Lys Asn Gly Gly Asn Met Gly Ala Ser Gly Ser Val Ser 
        115                 120                 125             

Tyr Leu Phe Asp Asn Lys Gly Val Ile Val Phe Gly Gly Glu Asp Ala 
    130                 135                 140                 

Asp Ala Val Phe Glu Gln Leu Leu Glu Ala Asp Val Asp Val Asp Asp 
145                 150                 155                 160 

Val Glu Ala Gln Glu Gly Thr Ile Thr Val Tyr Thr Ala Pro Thr Asp 
                165                 170                 175     

Leu His Lys Ala Ile Val Ala Leu Arg Glu Ser Gly Ile Glu Glu Phe 
            180                 185                 190         


Gln Val Thr Glu Leu Glu Met Ile Pro Gln Ser Glu Val Glu Leu Ser 
        195                 200                 205             

Gly Glu Asp Leu Glu Thr Phe Glu Lys Leu Tyr Ser Val Leu Glu Asp 
    210                 215                 220                 

Asp Glu Asp Val Gln Lys Ile Tyr Thr Asn Val Asp Gly Phe 
225                 230                 235             

<210>   4001
<211>   1413
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4001
atggcaaata aagcagtaaa tgactttata ctagctatga attacgataa aaagaaactc   60
ttgacccatc agggagaaag tattgaaaat cgtttcatca aagagggtaa tcagctaccc   120
gatgagtttg ttgttatcga aagaaagaag cggagcttgt cgacaaatac aagtgatatt   180
tctgtaacag ctaccaacga cagtcgcctc tatcctggag cacttctcgt agtggatgag   240

accttgttag agaataatcc cactcttctt gcggtcgatc gtgctccgat gacttatagt   300
attgatttgc ctggtttggc aagtagcgat agctttctcc aagtggaaga ccccagcaat   360
tcaagtgttc gcggagcggt aaacgatttg ttggctaagt ggcatcaaga ttatggtcag   420
gtcaataatg tcccagctag aatgcagtat gaaaaaatca cggctcacag catggaacaa   480
ctcaaggtca agtttggttc tgactttgaa aagacaggga attctcttga tattgatttt   540
aactctgtcc attcaggcga aaagcagatt cagattgtta attttaagca gatttattat   600
acagtcagcg tagatgctgt taaaaatcca ggagatgtgt ttcaagatac tgtaacggta   660
gaggatttaa aacagagagg aatttctgca gagcgtcctt tggtctatat ttcgagtgtt   720
gcttatgggc gccaagtcta tctcaagttg gaaaccacga gtaagagtga tgaagtagag   780
gctgcttttg aagctttgat aaaaggagtc aaggtagctc ctcagacaga gtggaaacag   840
attttggaca atacagaagt gaaggcggtt attttagggg gcgacccaag ttcgggtgcc   900
cgagttgtaa caggcaaggt ggatatggta gaggacttga ttcaagaagg cagtcgcttt   960
acagcagatc atccaggctt gccgatttcc tatacaactt cttttttacg tgacaatgta   1020
gttgcgacct ttcaaaatag tacagactat gttgagacta aggttacagc ttacagaaac   1080

ggagatttac tgctggatca tagtggtgcc tatgttgccc aatattatat tacttggaat   1140
gaattatcct atgatcatca aggtaaggaa gtcttgactc ctaaggcttg ggacagaaat   1200
gggcaggatt taacggctca ctttaccact agtattcctt taaaagggaa tgttcgtaat   1260
ctctctgtca aaattagaga gtgtaccggg cttgcctggg aatggtggcg tacggtttat   1320
gaaaaaaccg atttgccact agtgcgtaag cggacgattt ctatttgggg aacaactctc   1380
tatcctcagg tagaagataa ggtagaaaat gac                                1413

<210>   4002
<211>   471
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pneumolysin (ply)
<223>   Cellular location: cytoplasm
<223>   Feature of note: similar to alveolysin, toxin
<223>   Similar to strain R6 sequence 15903781 (0.E+01)

<400>   4002
Met Ala Asn Lys Ala Val Asn Asp Phe Ile Leu Ala Met Asn Tyr Asp 
1               5                   10                  15      

Lys Lys Lys Leu Leu Thr His Gln Gly Glu Ser Ile Glu Asn Arg Phe 
            20                  25                  30          

Ile Lys Glu Gly Asn Gln Leu Pro Asp Glu Phe Val Val Ile Glu Arg 
        35                  40                  45              

Lys Lys Arg Ser Leu Ser Thr Asn Thr Ser Asp Ile Ser Val Thr Ala 
    50                  55                  60                  

Thr Asn Asp Ser Arg Leu Tyr Pro Gly Ala Leu Leu Val Val Asp Glu 
65                  70                  75                  80  

Thr Leu Leu Glu Asn Asn Pro Thr Leu Leu Ala Val Asp Arg Ala Pro 
                85                  90                  95      

Met Thr Tyr Ser Ile Asp Leu Pro Gly Leu Ala Ser Ser Asp Ser Phe 
            100                 105                 110         

Leu Gln Val Glu Asp Pro Ser Asn Ser Ser Val Arg Gly Ala Val Asn 
        115                 120                 125             

Asp Leu Leu Ala Lys Trp His Gln Asp Tyr Gly Gln Val Asn Asn Val 
    130                 135                 140                 

Pro Ala Arg Met Gln Tyr Glu Lys Ile Thr Ala His Ser Met Glu Gln 
145                 150                 155                 160 

Leu Lys Val Lys Phe Gly Ser Asp Phe Glu Lys Thr Gly Asn Ser Leu 
                165                 170                 175     

Asp Ile Asp Phe Asn Ser Val His Ser Gly Glu Lys Gln Ile Gln Ile 
            180                 185                 190         

Val Asn Phe Lys Gln Ile Tyr Tyr Thr Val Ser Val Asp Ala Val Lys 
        195                 200                 205             

Asn Pro Gly Asp Val Phe Gln Asp Thr Val Thr Val Glu Asp Leu Lys 
    210                 215                 220                 

Gln Arg Gly Ile Ser Ala Glu Arg Pro Leu Val Tyr Ile Ser Ser Val 
225                 230                 235                 240 

Ala Tyr Gly Arg Gln Val Tyr Leu Lys Leu Glu Thr Thr Ser Lys Ser 
                245                 250                 255     

Asp Glu Val Glu Ala Ala Phe Glu Ala Leu Ile Lys Gly Val Lys Val 
            260                 265                 270         

Ala Pro Gln Thr Glu Trp Lys Gln Ile Leu Asp Asn Thr Glu Val Lys 
        275                 280                 285             

Ala Val Ile Leu Gly Gly Asp Pro Ser Ser Gly Ala Arg Val Val Thr 
    290                 295                 300                 

Gly Lys Val Asp Met Val Glu Asp Leu Ile Gln Glu Gly Ser Arg Phe 
305                 310                 315                 320 

Thr Ala Asp His Pro Gly Leu Pro Ile Ser Tyr Thr Thr Ser Phe Leu 
                325                 330                 335     

Arg Asp Asn Val Val Ala Thr Phe Gln Asn Ser Thr Asp Tyr Val Glu 
            340                 345                 350         

Thr Lys Val Thr Ala Tyr Arg Asn Gly Asp Leu Leu Leu Asp His Ser 
        355                 360                 365             

Gly Ala Tyr Val Ala Gln Tyr Tyr Ile Thr Trp Asn Glu Leu Ser Tyr 
    370                 375                 380                 

Asp His Gln Gly Lys Glu Val Leu Thr Pro Lys Ala Trp Asp Arg Asn 
385                 390                 395                 400 

Gly Gln Asp Leu Thr Ala His Phe Thr Thr Ser Ile Pro Leu Lys Gly 
                405                 410                 415     

Asn Val Arg Asn Leu Ser Val Lys Ile Arg Glu Cys Thr Gly Leu Ala 
            420                 425                 430         

Trp Glu Trp Trp Arg Thr Val Tyr Glu Lys Thr Asp Leu Pro Leu Val 
        435                 440                 445             

Arg Lys Arg Thr Ile Ser Ile Trp Gly Thr Thr Leu Tyr Pro Gln Val 
    450                 455                 460                 

Glu Asp Lys Val Glu Asn Asp 
465                 470     

<210>   4003
<211>   408
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4003
ttgattaaga gaggagatgt tgtagctctt tatttgcctt ttccgactat tagtagcgat   60
ttggctgtga agaatcatat gtatatctgt attgacaaca gcatgactaa aaacaaagag   120
ttggttaaaa atcagacctt caaaccagct ctcttgacca gacgtttggt caagaacttt   180
atgatagaag agccggatct agctcgtaat ccttttacaa gaccaacctt gattgactta   240
gataaggtat ttatgttgga taatacggtc attccgactt cttatttagc cagacggcga   300
cgcaatgtct cagaagaatt gtacgaggaa attttggatt acttagtcca accacggctg   360
atttcgctga acaagtctga gtttatgcaa ctcaatccag gaacttat                408


<210>   4004
<211>   136
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903782 (2.E-74)

<400>   4004
Met Ile Lys Arg Gly Asp Val Val Ala Leu Tyr Leu Pro Phe Pro Thr 
1               5                   10                  15      

Ile Ser Ser Asp Leu Ala Val Lys Asn His Met Tyr Ile Cys Ile Asp 
            20                  25                  30          

Asn Ser Met Thr Lys Asn Lys Glu Leu Val Lys Asn Gln Thr Phe Lys 
        35                  40                  45              

Pro Ala Leu Leu Thr Arg Arg Leu Val Lys Asn Phe Met Ile Glu Glu 
    50                  55                  60                  

Pro Asp Leu Ala Arg Asn Pro Phe Thr Arg Pro Thr Leu Ile Asp Leu 
65                  70                  75                  80  

Asp Lys Val Phe Met Leu Asp Asn Thr Val Ile Pro Thr Ser Tyr Leu 
                85                  90                  95      

Ala Arg Arg Arg Arg Asn Val Ser Glu Glu Leu Tyr Glu Glu Ile Leu 
            100                 105                 110         

Asp Tyr Leu Val Gln Pro Arg Leu Ile Ser Leu Asn Lys Ser Glu Phe 
        115                 120                 125             

Met Gln Leu Asn Pro Gly Thr Tyr 
    130                 135     

<210>   4005
<211>   606
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4005
atgtctcaat ccagctacct gtcgcccttg ctctggttaa aaaaagaagc cgataaggaa   60
aagatgagcg cgacccagtg ccagatattt ttcttttact atcaaatgtt tgagctctta   120
tttgctagag aaagcgacat gaaagactta tgtctgggaa cgaaaggttt ttatttctcg   180
cagttagaga aaaatttgct ttctggagtt tcccgatttc taaaaaactt ggaggggaaa   240
gtaactctca aggctaacca agaagtatca gctcgcaaag ccctttttct agccttgaca   300
actagccaat cagattggca ggagttagct cctgtttttg atttttatca gactatcggg   360
aggcttgaaa atccttctct cttgagttct caggacagac aacatctgat gtggatttac   420
cagtcagctt tggagaagga ttatattgtc aaggttattg gcgacaagca ttttgtattg   480
aagagacaag atgctactaa attgacagcg cgccaaactc aaactttgga aattctgagt   540
caatcagaag acttggtcaa tcctgtctat gttacattag gagaaaaggg ggtgctcttg   600
cttgat                                                              606

<210>   4006
<211>   202
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903783 (e-113)

<400>   4006
Met Ser Gln Ser Ser Tyr Leu Ser Pro Leu Leu Trp Leu Lys Lys Glu 
1               5                   10                  15      

Ala Asp Lys Glu Lys Met Ser Ala Thr Gln Cys Gln Ile Phe Phe Phe 
            20                  25                  30          

Tyr Tyr Gln Met Phe Glu Leu Leu Phe Ala Arg Glu Ser Asp Met Lys 
        35                  40                  45              

Asp Leu Cys Leu Gly Thr Lys Gly Phe Tyr Phe Ser Gln Leu Glu Lys 
    50                  55                  60                  

Asn Leu Leu Ser Gly Val Ser Arg Phe Leu Lys Asn Leu Glu Gly Lys 
65                  70                  75                  80  

Val Thr Leu Lys Ala Asn Gln Glu Val Ser Ala Arg Lys Ala Leu Phe 
                85                  90                  95      

Leu Ala Leu Thr Thr Ser Gln Ser Asp Trp Gln Glu Leu Ala Pro Val 
            100                 105                 110         

Phe Asp Phe Tyr Gln Thr Ile Gly Arg Leu Glu Asn Pro Ser Leu Leu 
        115                 120                 125             

Ser Ser Gln Asp Arg Gln His Leu Met Trp Ile Tyr Gln Ser Ala Leu 
    130                 135                 140                 

Glu Lys Asp Tyr Ile Val Lys Val Ile Gly Asp Lys His Phe Val Leu 
145                 150                 155                 160 

Lys Arg Gln Asp Ala Thr Lys Leu Thr Ala Arg Gln Thr Gln Thr Leu 
                165                 170                 175     

Glu Ile Leu Ser Gln Ser Glu Asp Leu Val Asn Pro Val Tyr Val Thr 
            180                 185                 190         

Leu Gly Glu Lys Gly Val Leu Leu Leu Asp 
        195                 200         

<210>   4007
<211>   474
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4007
atgaaaggag ttacgaatat gacgccagaa gaaatgtacc tgacagagcg attagacgta   60
cagatagctc attttttaaa gaaaagcgtt caacatcgta ggcgctataa ggtattaaaa   120
ataacagaaa tcgtggcagg tttcctcata gctgtctttt gtgctattcc tatgccaggt   180
gatcgctacc gtttgatttc ggttgcctta tccagtctcg gcttgctgtg tgaggggatt   240
atcaatttgt ataatgcaaa ggaaaattgg atttcttacc aaaaaactgc gcaactcctg   300
gagaaagaaa aattcctcta tcaatgccaa acggagaaat atgcaggaaa gaccaaggct   360
tttgccctat ttgtcaagac atgcgaaggt cttatctcag aggagattaa ccagtgggaa   420
agtatccagt caaaagaagt ggcagctagt gcagatgctc cagttaaaaa agag         474

<210>   4008
<211>   158
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903784 (1.E-54)

<400>   4008
Met Lys Gly Val Thr Asn Met Thr Pro Glu Glu Met Tyr Leu Thr Glu 
1               5                   10                  15      

Arg Leu Asp Val Gln Ile Ala His Phe Leu Lys Lys Ser Val Gln His 
            20                  25                  30          

Arg Arg Arg Tyr Lys Val Leu Lys Ile Thr Glu Ile Val Ala Gly Phe 
        35                  40                  45              

Leu Ile Ala Val Phe Cys Ala Ile Pro Met Pro Gly Asp Arg Tyr Arg 
    50                  55                  60                  

Leu Ile Ser Val Ala Leu Ser Ser Leu Gly Leu Leu Cys Glu Gly Ile 
65                  70                  75                  80  

Ile Asn Leu Tyr Asn Ala Lys Glu Asn Trp Ile Ser Tyr Gln Lys Thr 
                85                  90                  95      

Ala Gln Leu Leu Glu Lys Glu Lys Phe Leu Tyr Gln Cys Gln Thr Glu 
            100                 105                 110         

Lys Tyr Ala Gly Lys Thr Lys Ala Phe Ala Leu Phe Val Lys Thr Cys 
        115                 120                 125             

Glu Gly Leu Ile Ser Glu Glu Ile Asn Gln Trp Glu Ser Ile Gln Ser 
    130                 135                 140                 

Lys Glu Val Ala Ala Ser Ala Asp Ala Pro Val Lys Lys Glu 
145                 150                 155             

<210>   4009
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4009
atgaattatg aagcaagtaa acaactaact gatgcacgat ttaagcgtct tgttggtgtt   60
cagcgcacga cttttgaaga gatattagct gtattaaaaa cagcttatca acttaaacac   120
gcaaaaggtg gacgaaaacc taaattaaac ctagaagacc ttcttatggc cactcttcaa   180
tatgtgcgag aataccgcac ttatgaagaa attgcggctg attttggtat tcacgaaagc   240
aacttaatcc gtcggagcca atgggttgaa gtaactcttg ttcaaagtgg tgttacgatt   300
tcaagaactc ctcttagttc tgaggacacg gtaatgattg atgcgacgga agtaaaaatc   360
aatcgcccta aaaaaagaat tagcgaa                                       387

<210>   4010
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902886 (4.E-66)

<400>   4010
Met Asn Tyr Glu Ala Ser Lys Gln Leu Thr Asp Ala Arg Phe Lys Arg 
1               5                   10                  15      

Leu Val Gly Val Gln Arg Thr Thr Phe Glu Glu Ile Leu Ala Val Leu 
            20                  25                  30          

Lys Thr Ala Tyr Gln Leu Lys His Ala Lys Gly Gly Arg Lys Pro Lys 
        35                  40                  45              

Leu Asn Leu Glu Asp Leu Leu Met Ala Thr Leu Gln Tyr Val Arg Glu 
    50                  55                  60                  

Tyr Arg Thr Tyr Glu Glu Ile Ala Ala Asp Phe Gly Ile His Glu Ser 
65                  70                  75                  80  

Asn Leu Ile Arg Arg Ser Gln Trp Val Glu Val Thr Leu Val Gln Ser 
                85                  90                  95      

Gly Val Thr Ile Ser Arg Thr Pro Leu Ser Ser Glu Asp Thr Val Met 
            100                 105                 110         

Ile Asp Ala Thr Glu Val Lys Ile Asn Arg Pro Lys Lys Arg Ile Ser 
        115                 120                 125             


Glu 
    

<210>   4011
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4011
atgaaggctc aagcgattgt cacaagtcaa gggagaattg tttctttgga tatcactgtg   60
aactattgtc atgatatgaa gttgttcaaa atgagttgca gaaatatcgg acaagctggt   120
aaaatcttgg ctgacagtgg ttatcaaggg ctcatgaaga tatgtcctca agcacaaact   180
ccacgtaaat ccagcaaact caagccgcta acagctgaag ataaagccta taaccatgcg   240
ctatctaagg agagaagcaa ggttgagaac atctttgcca aagtagaaac gtttaaaatg   300
ttttcaacaa cctatcgaaa tcatcgtaaa cgctttggat tacgaatgaa tttgattgct   360
ggtattatca atcatgaact aggattc                                       387

<210>   4012
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfB FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903038 (6.E-68)

<400>   4012
Met Lys Ala Gln Ala Ile Val Thr Ser Gln Gly Arg Ile Val Ser Leu 
1               5                   10                  15      

Asp Ile Thr Val Asn Tyr Cys His Asp Met Lys Leu Phe Lys Met Ser 
            20                  25                  30          

Cys Arg Asn Ile Gly Gln Ala Gly Lys Ile Leu Ala Asp Ser Gly Tyr 
        35                  40                  45              

Gln Gly Leu Met Lys Ile Cys Pro Gln Ala Gln Thr Pro Arg Lys Ser 
    50                  55                  60                  

Ser Lys Leu Lys Pro Leu Thr Ala Glu Asp Lys Ala Tyr Asn His Ala 
65                  70                  75                  80  

Leu Ser Lys Glu Arg Ser Lys Val Glu Asn Ile Phe Ala Lys Val Glu 
                85                  90                  95      

Thr Phe Lys Met Phe Ser Thr Thr Tyr Arg Asn His Arg Lys Arg Phe 
            100                 105                 110         

Gly Leu Arg Met Asn Leu Ile Ala Gly Ile Ile Asn His Glu Leu Gly 
        115                 120                 125             

Phe 
    

<210>   4013
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4013
atgaaacgag aacaggacaa attgatcagg acagtcaaat cgatttctaa caatgtttta   60
gaagcagaag tgtactattc tagtttcaat ctacta                             96

<210>   4014
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4014
Met Lys Arg Glu Gln Asp Lys Leu Ile Arg Thr Val Lys Ser Ile Ser 
1               5                   10                  15      

Asn Asn Val Leu Glu Ala Glu Val Tyr Tyr Ser Ser Phe Asn Leu Leu 
            20                  25                  30          


<210>   4015
<211>   258
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4015
atgagggagc gctctgccac aggtgctcaa ggtttaagta agtccattaa aaagcatttg   60
aatgacctta cccgtttgac agcttccttg ctaggagatg aaaagttatc ggctataaca   120
tcaagtagtg cggtaaaagc agacatgcac cgctttgtga tagaattaga gcctgtgaag   180
tcaactattc ttcaaaataa tgacatttca ttggatcaaa atgaaatttt tgaaattctg   240
aaaaattttc tcgatggt                                                 258

<210>   4016
<211>   86
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903788 (9.E-43)

<400>   4016
Met Arg Glu Arg Ser Ala Thr Gly Ala Gln Gly Leu Ser Lys Ser Ile 
1               5                   10                  15      

Lys Lys His Leu Asn Asp Leu Thr Arg Leu Thr Ala Ser Leu Leu Gly 
            20                  25                  30          

Asp Glu Lys Leu Ser Ala Ile Thr Ser Ser Ser Ala Val Lys Ala Asp 
        35                  40                  45              

Met His Arg Phe Val Ile Glu Leu Glu Pro Val Lys Ser Thr Ile Leu 
    50                  55                  60                  

Gln Asn Asn Asp Ile Ser Leu Asp Gln Asn Glu Ile Phe Glu Ile Leu 
65                  70                  75                  80  

Lys Asn Phe Leu Asp Gly 
                85      

<210>   4017
<211>   123
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4017
ttgtggttta tactcttcga aaatctcttc aaaccacgtc agcttccatc tacaacctca   60
aaacagtgtt ttgagcagcc tgcagctagc ttcctagttt gctctttgat tttcattgag   120
tat                                                                 123

<210>   4018
<211>   41
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4018
Met Trp Phe Ile Leu Phe Glu Asn Leu Phe Lys Pro Arg Gln Leu Pro 
1               5                   10                  15      

Ser Thr Thr Ser Lys Gln Cys Phe Glu Gln Pro Ala Ala Ser Phe Leu 
            20                  25                  30          

Val Cys Ser Leu Ile Phe Ile Glu Tyr 
        35                  40      

<210>   4019
<211>   552
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4019
atgatgccag ctaatacgaa agttattttt caagaaatgt ttgcggattt tcagaactat   60
tatgttctga ttgggggaac tgctacctct atcgtattgg attcgcaagg atttaaaagt   120
cgcacaacaa aagattatga tatggtcatc attgatgaag taaaaaataa ggaattttat   180
actaccttga atcatttttt agaattggga gagtatcaag gaagtcagaa agatgagaaa   240
gcgcagcttt ttcgatttac aacaactaat cctgagtttc cttctatgat tgaactattt   300
agtatcttac cagaatatcc attaaagaag gacggtcgag aaattccctt acattttgac   360
caagatgcta gtttatcagc cttattattg gatgaagatt attataatat attggtgcat   420
gaaaaagaaa ccattcaggg gtattcggta ttgagtaatt gtggtttata ctcttcgaaa   480
atctcttcaa accacgtcag cttccatcta caacctcaaa acagtgtttt gagcagcctg   540
cagctagctt cc                                                       552

<210>   4020
<211>   184
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein, fusion
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903789 (e-101)

<400>   4020
Met Met Pro Ala Asn Thr Lys Val Ile Phe Gln Glu Met Phe Ala Asp 
1               5                   10                  15      

Phe Gln Asn Tyr Tyr Val Leu Ile Gly Gly Thr Ala Thr Ser Ile Val 
            20                  25                  30          

Leu Asp Ser Gln Gly Phe Lys Ser Arg Thr Thr Lys Asp Tyr Asp Met 
        35                  40                  45              

Val Ile Ile Asp Glu Val Lys Asn Lys Glu Phe Tyr Thr Thr Leu Asn 
    50                  55                  60                  

His Phe Leu Glu Leu Gly Glu Tyr Gln Gly Ser Gln Lys Asp Glu Lys 
65                  70                  75                  80  

Ala Gln Leu Phe Arg Phe Thr Thr Thr Asn Pro Glu Phe Pro Ser Met 
                85                  90                  95      

Ile Glu Leu Phe Ser Ile Leu Pro Glu Tyr Pro Leu Lys Lys Asp Gly 
            100                 105                 110         

Arg Glu Ile Pro Leu His Phe Asp Gln Asp Ala Ser Leu Ser Ala Leu 
        115                 120                 125             

Leu Leu Asp Glu Asp Tyr Tyr Asn Ile Leu Val His Glu Lys Glu Thr 
    130                 135                 140                 

Ile Gln Gly Tyr Ser Val Leu Ser Asn Cys Gly Leu Tyr Ser Ser Lys 
145                 150                 155                 160 

Ile Ser Ser Asn His Val Ser Phe His Leu Gln Pro Gln Asn Ser Val 
                165                 170                 175     

Leu Ser Ser Leu Gln Leu Ala Ser 
            180                 

<210>   4021
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4021
ttgaccttaa aagatgatga tgacccacgt atagaggaag agagtgaagc actagaaaat   60
atgatattac agtatctggg agaagatgat gccagc                             96

<210>   4022
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903790 (2.E-13)

<400>   4022
Met Thr Leu Lys Asp Asp Asp Asp Pro Arg Ile Glu Glu Glu Ser Glu 
1               5                   10                  15      

Ala Leu Glu Asn Met Ile Leu Gln Tyr Leu Gly Glu Asp Asp Ala Ser 
            20                  25                  30          


<210>   4023
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4023
atggcagaga aaattcaatc agttatcctt gccactttct cagcatgttt taaaatgaaa   60
gatgctagag atatggaaat atcgtccttt tgtatc                             96

<210>   4024
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4024
Met Ala Glu Lys Ile Gln Ser Val Ile Leu Ala Thr Phe Ser Ala Cys 
1               5                   10                  15      

Phe Lys Met Lys Asp Ala Arg Asp Met Glu Ile Ser Ser Phe Cys Ile 
            20                  25                  30          


<210>   4025
<211>   792
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4025
atgaatgtca aaaagataat gtcaattttt caatcctttt atgttgatgt cagtattgag   60
gaactgactt tgactttacc aatcagtttt gtaaaaaggt ttgagtatac tcaaatgact   120
tttcataagg aatcattttt attgattaaa gaaaagagaa gggggagttt gagttcattt   180
gttactcagg ctcgcactat gggtgaaaaa gccaatatgg atgttgtttt ggtgttttcg   240
aagttatcag acagtgaaaa aaagcaatta cttcaagcta gagttccgtt tgtagacttt   300
aagggaaacc tcttcttccc tccattggga ctagtactca atgcgaatga tactgaagtc   360
cctaaggaat taacacctag cgaacaatta acgtggattg cctttttatt gacaaaaggt   420
caaaaagtag tagatgttga tttgctttca caagtcactg gacttccaaa ctcaacaatt   480
tataggtgtt tgaggacttt taaagcttta tattggttaa acaagcaaaa taagctttac   540
acatatacgg tgtcaaagaa agaattattc ttaaaatccg tgtcatgttt atttaatccc   600
atcaaaaaac ggattttatt gccagatggc gatataaagc agataaaatc tgtttctaac   660
cttctatatg gtggtgctta tgctttgtcg cattcaactt ttttagctga aacggatgaa   720
aatattagct atgtcatatg gcagagaaaa ttcaatcagt tatccttgcc actttctcag   780
catgttttaa aa                                                       792

<210>   4026
<211>   264
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903791 (e-149)

<400>   4026
Met Asn Val Lys Lys Ile Met Ser Ile Phe Gln Ser Phe Tyr Val Asp 
1               5                   10                  15      

Val Ser Ile Glu Glu Leu Thr Leu Thr Leu Pro Ile Ser Phe Val Lys 
            20                  25                  30          

Arg Phe Glu Tyr Thr Gln Met Thr Phe His Lys Glu Ser Phe Leu Leu 
        35                  40                  45              

Ile Lys Glu Lys Arg Arg Gly Ser Leu Ser Ser Phe Val Thr Gln Ala 
    50                  55                  60                  

Arg Thr Met Gly Glu Lys Ala Asn Met Asp Val Val Leu Val Phe Ser 
65                  70                  75                  80  

Lys Leu Ser Asp Ser Glu Lys Lys Gln Leu Leu Gln Ala Arg Val Pro 
                85                  90                  95      

Phe Val Asp Phe Lys Gly Asn Leu Phe Phe Pro Pro Leu Gly Leu Val 
            100                 105                 110         

Leu Asn Ala Asn Asp Thr Glu Val Pro Lys Glu Leu Thr Pro Ser Glu 
        115                 120                 125             

Gln Leu Thr Trp Ile Ala Phe Leu Leu Thr Lys Gly Gln Lys Val Val 
    130                 135                 140                 

Asp Val Asp Leu Leu Ser Gln Val Thr Gly Leu Pro Asn Ser Thr Ile 
145                 150                 155                 160 

Tyr Arg Cys Leu Arg Thr Phe Lys Ala Leu Tyr Trp Leu Asn Lys Gln 
                165                 170                 175     

Asn Lys Leu Tyr Thr Tyr Thr Val Ser Lys Lys Glu Leu Phe Leu Lys 
            180                 185                 190         

Ser Val Ser Cys Leu Phe Asn Pro Ile Lys Lys Arg Ile Leu Leu Pro 
        195                 200                 205             

Asp Gly Asp Ile Lys Gln Ile Lys Ser Val Ser Asn Leu Leu Tyr Gly 
    210                 215                 220                 

Gly Ala Tyr Ala Leu Ser His Ser Thr Phe Leu Ala Glu Thr Asp Glu 
225                 230                 235                 240 

Asn Ile Ser Tyr Val Ile Trp Gln Arg Lys Phe Asn Gln Leu Ser Leu 
                245                 250                 255     

Pro Leu Ser Gln His Val Leu Lys 
            260                 

<210>   4027
<211>   423
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4027
ttgactagtc gtgtatttat tgatgcagat tgtatttcag tatttttatg ggttggcact   60
gaacatcttt tagaaaagct ctatttgggt aaaattgtta ttccacaaga ggtgtatgat   120
gaaatcaata tacctacaat tccccattta aaatctagga tagatcagtt ggtagctaag   180
ggttcagctg agattgtgag catagacatt ggaactgaag aatacgcatt atatagagat   240
ttaacaagaa atcatgatag taacaagatt attggtaagg gagaaggggc atctatttcc   300
ttagcgaaaa agcataatgg gatattagga agtaataacc taagagatgt taaatcatat   360
gtagaagaat tttctttaga atatatgaca acaggagata tactgattga agcgtttaaa   420
gcg                                                                 423

<210>   4028
<211>   141
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903792 (6.E-75)

<400>   4028
Met Thr Ser Arg Val Phe Ile Asp Ala Asp Cys Ile Ser Val Phe Leu 
1               5                   10                  15      

Trp Val Gly Thr Glu His Leu Leu Glu Lys Leu Tyr Leu Gly Lys Ile 
            20                  25                  30          

Val Ile Pro Gln Glu Val Tyr Asp Glu Ile Asn Ile Pro Thr Ile Pro 
        35                  40                  45              

His Leu Lys Ser Arg Ile Asp Gln Leu Val Ala Lys Gly Ser Ala Glu 
    50                  55                  60                  

Ile Val Ser Ile Asp Ile Gly Thr Glu Glu Tyr Ala Leu Tyr Arg Asp 
65                  70                  75                  80  

Leu Thr Arg Asn His Asp Ser Asn Lys Ile Ile Gly Lys Gly Glu Gly 
                85                  90                  95      

Ala Ser Ile Ser Leu Ala Lys Lys His Asn Gly Ile Leu Gly Ser Asn 
            100                 105                 110         

Asn Leu Arg Asp Val Lys Ser Tyr Val Glu Glu Phe Ser Leu Glu Tyr 
        115                 120                 125             

Met Thr Thr Gly Asp Ile Leu Ile Glu Ala Phe Lys Ala 
    130                 135                 140     

<210>   4029
<211>   357
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4029
gtgaagaaga gttcagtcag tcttatcttg attggtgaag gagatgaaac tgaaagaaaa   60
gcggatcagt ttgcttctta ttttttaatt ttcccatctt cactgtatag gatggttgag   120
gaaatcagag aaaatgccaa tagaactcat cttgaagtag aagatattat aaaattgggt   180
cagttttatg gtatcagtca taaagctatg ttatatagat tgaggaatga tggatacctt   240
gatgcagaag aaattaaaaa tatggatatt agtgttatag agacagcttc aagattaggc   300
tatgatacaa gtttatatcg tcctttgtca gaaagtaaaa aagaaatggc attagga      357

<210>   4030
<211>   119
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903793 (2.E-62)

<400>   4030
Met Lys Lys Ser Ser Val Ser Leu Ile Leu Ile Gly Glu Gly Asp Glu 
1               5                   10                  15      

Thr Glu Arg Lys Ala Asp Gln Phe Ala Ser Tyr Phe Leu Ile Phe Pro 
            20                  25                  30          

Ser Ser Leu Tyr Arg Met Val Glu Glu Ile Arg Glu Asn Ala Asn Arg 
        35                  40                  45              

Thr His Leu Glu Val Glu Asp Ile Ile Lys Leu Gly Gln Phe Tyr Gly 
    50                  55                  60                  

Ile Ser His Lys Ala Met Leu Tyr Arg Leu Arg Asn Asp Gly Tyr Leu 
65                  70                  75                  80  

Asp Ala Glu Glu Ile Lys Asn Met Asp Ile Ser Val Ile Glu Thr Ala 
                85                  90                  95      

Ser Arg Leu Gly Tyr Asp Thr Ser Leu Tyr Arg Pro Leu Ser Glu Ser 
            100                 105                 110         

Lys Lys Glu Met Ala Leu Gly 
        115                 

<210>   4031
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4031
atgtatgtga taaatgtatg tgatgttgga aaaagaataa aagaacttag aatatcttca   60
aatcttactc aagataagat tgctgagtat ttgtctttga atcaaagcat gattgccaaa   120
atggaaaaag gtgaaaggaa tatcacgaat ggatttaag                          159

<210>   4032
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type II restriction-modification system regulatory protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903795 (5.E-24)

<400>   4032
Met Tyr Val Ile Asn Val Cys Asp Val Gly Lys Arg Ile Lys Glu Leu 
1               5                   10                  15      

Arg Ile Ser Ser Asn Leu Thr Gln Asp Lys Ile Ala Glu Tyr Leu Ser 
            20                  25                  30          

Leu Asn Gln Ser Met Ile Ala Lys Met Glu Lys Gly Glu Arg Asn Ile 
        35                  40                  45              

Thr Asn Gly Phe Lys 
    50              

<210>   4033
<211>   954
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4033
atggaaatta atgtgagtaa attaagaaca gatttgcctc aagtcggcgt gcaaccatat   60
aggcaagtac acgcacactc aactgggaat ccgcattcaa ccgtacagaa tgaagcggat   120
tatcactggc ggaaagaccc agaattaggt tttttctcgc acattgttgg gaacggttgc   180
atcatgcagg taggacctgt tgataatggt gcctgggacg ttgggggcgg ttggaatgct   240
gagacctatg cagcggttga actgattgaa agccattcaa ccaaagaaga gttcatgacg   300
gactaccgcc tttatatcga actcttacgc aatctagcag atgaagcagg tttgccgaaa   360
acgcttgata cagggagttt agctggaatt aaaacgcacg agtattgcac gaataaccaa   420
ccaaacaacc actcagacca cgttgaccct tatccatatc ttgctaaatg gggcattagc   480
cgtgagcagt ttaagcatga tattgagaac ggcttgacga ttgaaacagg ctggcagaag   540
aatgacactg gctactggta cgtacattca gacggctctt atccaaaaga caagtttgag   600
aaaatcaatg gcacttggta ctactttgac agttcaggct atatgcttgc agaccgctgg   660
aggaagcaca cagacggcaa ctggtactgg ttcgacaact caggcgaaat ggctacaggc   720
tggaagaaaa tcgctgataa gtggtactat ttcaacgaag aaggtgccat gaagacaggc   780
tgggtcaagt acaaggacac ttggtactac ttagacgcta aagaaggcgc catggtatca   840
aatgccttta tccagtcagc ggacggaaca ggctggtact acctcaaacc agacggaaca   900
ctggcagaca agccagaatt cacagtagag ccagatggct tgattacagt aaaa         954

<210>   4034
<211>   318
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   autolysin (lytA)
<223>   Cellular location: cytoplasm
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15903796 (0.E+01)

<400>   4034
Met Glu Ile Asn Val Ser Lys Leu Arg Thr Asp Leu Pro Gln Val Gly 
1               5                   10                  15      

Val Gln Pro Tyr Arg Gln Val His Ala His Ser Thr Gly Asn Pro His 
            20                  25                  30          

Ser Thr Val Gln Asn Glu Ala Asp Tyr His Trp Arg Lys Asp Pro Glu 
        35                  40                  45              

Leu Gly Phe Phe Ser His Ile Val Gly Asn Gly Cys Ile Met Gln Val 
    50                  55                  60                  

Gly Pro Val Asp Asn Gly Ala Trp Asp Val Gly Gly Gly Trp Asn Ala 
65                  70                  75                  80  

Glu Thr Tyr Ala Ala Val Glu Leu Ile Glu Ser His Ser Thr Lys Glu 
                85                  90                  95      

Glu Phe Met Thr Asp Tyr Arg Leu Tyr Ile Glu Leu Leu Arg Asn Leu 
            100                 105                 110         

Ala Asp Glu Ala Gly Leu Pro Lys Thr Leu Asp Thr Gly Ser Leu Ala 
        115                 120                 125             

Gly Ile Lys Thr His Glu Tyr Cys Thr Asn Asn Gln Pro Asn Asn His 
    130                 135                 140                 

Ser Asp His Val Asp Pro Tyr Pro Tyr Leu Ala Lys Trp Gly Ile Ser 
145                 150                 155                 160 

Arg Glu Gln Phe Lys His Asp Ile Glu Asn Gly Leu Thr Ile Glu Thr 
                165                 170                 175     

Gly Trp Gln Lys Asn Asp Thr Gly Tyr Trp Tyr Val His Ser Asp Gly 
            180                 185                 190         

Ser Tyr Pro Lys Asp Lys Phe Glu Lys Ile Asn Gly Thr Trp Tyr Tyr 
        195                 200                 205             

Phe Asp Ser Ser Gly Tyr Met Leu Ala Asp Arg Trp Arg Lys His Thr 
    210                 215                 220                 

Asp Gly Asn Trp Tyr Trp Phe Asp Asn Ser Gly Glu Met Ala Thr Gly 
225                 230                 235                 240 

Trp Lys Lys Ile Ala Asp Lys Trp Tyr Tyr Phe Asn Glu Glu Gly Ala 
                245                 250                 255     

Met Lys Thr Gly Trp Val Lys Tyr Lys Asp Thr Trp Tyr Tyr Leu Asp 
            260                 265                 270         

Ala Lys Glu Gly Ala Met Val Ser Asn Ala Phe Ile Gln Ser Ala Asp 
        275                 280                 285             

Gly Thr Gly Trp Tyr Tyr Leu Lys Pro Asp Gly Thr Leu Ala Asp Lys 
    290                 295                 300                 

Pro Glu Phe Thr Val Glu Pro Asp Gly Leu Ile Thr Val Lys 
305                 310                 315             

<210>   4035
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4035
atgaaaagga catatagaga ctgtaaaaat atacttttga aaatcttttt agtctggggt   60
gttattgtag atagaatgca gaccttgtca gtcctattta cagtgtcaaa a            111

<210>   4036
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4036
Met Lys Arg Thr Tyr Arg Asp Cys Lys Asn Ile Leu Leu Lys Ile Phe 
1               5                   10                  15      

Leu Val Trp Gly Val Ile Val Asp Arg Met Gln Thr Leu Ser Val Leu 
            20                  25                  30          

Phe Thr Val Ser Lys 
        35          

<210>   4037
<211>   1368
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4037
atgaataaaa aacgaacagt ggacctgata catggtccga ttcttccctc gctcttaagc   60
ttcacctttc caattttgct atcaaatatt tttcaacagc tctataacac tgctgatgtc   120
ttgattgttg gacgatttct tggtcaagaa tccttggctg cagtaggagc gacgacagcg   180
atttttgacc tgattgtagg ttttacactt ggtgttggca atggcatggg gattgtcatt   240
gctcgttatt atggggctcg gaatttcact aaaatcaagg aagcagtagc agccacctgg   300
attttaggtg ctcttttgag cattctagtt atgttgctgg gctttcttgg cttgtatcct   360
ctcttgcaat acttagatac tcctgcagaa attcttcctc aatcttatca atatatttct   420
atgattgtga cctgtgtagg tgtcagcttt gcttataatc tttttgcagg cttgttgcgg   480
tctattggtg acagtctagc agccctggga tttctgattt tctctgcctt ggttaatgtg   540
gttctggatc tctattttat tacgcaattg catctgggag ttcaatccgc aggacttgct   600
accattattt cgcaaggttt atcagcggtt ctctgctttt attatattcg taaaagtgtg   660
ccagaactct tgccacagtt taaacatttc aaatgggaca aaagcttgta cgcggatctc   720
ttggagcaag gtttggctat gggcttgatg agttcaattg tatctatcgg cagtgtgatt   780
ttacagtttt ctgttaatac atttggtgca gtgattatta gtgcccagac ggcagctcga   840
cgcattatga cctttgccct tcttcctatg accgctattt ctgcatcaat gacgaccttt   900
gcttctcaga atctaggagc taagcgacct gaccgtattg ttcaaggtct tcgaatcggc   960
agtcgtttaa gtatatcctg ggcagttttt gtttgtattt tcctcttttt tgccagtcca   1020
gctttggttt ccttcttggc tagttcgaca gatggttact tgatagaaaa tggaagtctc   1080
tatctgcaaa tcagttcaac cttttatccc attttgagcc tcttgttgat ttatcgcaat   1140
tgcttgcagg gcttggggca aaagatcctt cctctagttt ctagctttat tgaactaatc   1200
ggaaaaatcg tttttgtggt tttgattatt ccttgggcag gatataaggg tgttatcctt   1260
tgtgaacctc ttatctgggt tgccatgaca gttcaactgt acttctcatt attccgtcat   1320
cccttgataa aagaaggcaa ggcaatcttg gcaaccaaag tgcaatcc                1368

<210>   4038
<211>   456
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MATE efflux family protein DinF (dinF)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903798 (0.E+01)

<400>   4038
Met Asn Lys Lys Arg Thr Val Asp Leu Ile His Gly Pro Ile Leu Pro 
1               5                   10                  15      

Ser Leu Leu Ser Phe Thr Phe Pro Ile Leu Leu Ser Asn Ile Phe Gln 
            20                  25                  30          

Gln Leu Tyr Asn Thr Ala Asp Val Leu Ile Val Gly Arg Phe Leu Gly 
        35                  40                  45              

Gln Glu Ser Leu Ala Ala Val Gly Ala Thr Thr Ala Ile Phe Asp Leu 
    50                  55                  60                  

Ile Val Gly Phe Thr Leu Gly Val Gly Asn Gly Met Gly Ile Val Ile 
65                  70                  75                  80  

Ala Arg Tyr Tyr Gly Ala Arg Asn Phe Thr Lys Ile Lys Glu Ala Val 
                85                  90                  95      

Ala Ala Thr Trp Ile Leu Gly Ala Leu Leu Ser Ile Leu Val Met Leu 
            100                 105                 110         

Leu Gly Phe Leu Gly Leu Tyr Pro Leu Leu Gln Tyr Leu Asp Thr Pro 
        115                 120                 125             

Ala Glu Ile Leu Pro Gln Ser Tyr Gln Tyr Ile Ser Met Ile Val Thr 
    130                 135                 140                 

Cys Val Gly Val Ser Phe Ala Tyr Asn Leu Phe Ala Gly Leu Leu Arg 
145                 150                 155                 160 

Ser Ile Gly Asp Ser Leu Ala Ala Leu Gly Phe Leu Ile Phe Ser Ala 
                165                 170                 175     

Leu Val Asn Val Val Leu Asp Leu Tyr Phe Ile Thr Gln Leu His Leu 
            180                 185                 190         

Gly Val Gln Ser Ala Gly Leu Ala Thr Ile Ile Ser Gln Gly Leu Ser 
        195                 200                 205             

Ala Val Leu Cys Phe Tyr Tyr Ile Arg Lys Ser Val Pro Glu Leu Leu 
    210                 215                 220                 

Pro Gln Phe Lys His Phe Lys Trp Asp Lys Ser Leu Tyr Ala Asp Leu 
225                 230                 235                 240 

Leu Glu Gln Gly Leu Ala Met Gly Leu Met Ser Ser Ile Val Ser Ile 
                245                 250                 255     

Gly Ser Val Ile Leu Gln Phe Ser Val Asn Thr Phe Gly Ala Val Ile 
            260                 265                 270         

Ile Ser Ala Gln Thr Ala Ala Arg Arg Ile Met Thr Phe Ala Leu Leu 
        275                 280                 285             

Pro Met Thr Ala Ile Ser Ala Ser Met Thr Thr Phe Ala Ser Gln Asn 
    290                 295                 300                 

Leu Gly Ala Lys Arg Pro Asp Arg Ile Val Gln Gly Leu Arg Ile Gly 
305                 310                 315                 320 

Ser Arg Leu Ser Ile Ser Trp Ala Val Phe Val Cys Ile Phe Leu Phe 
                325                 330                 335     

Phe Ala Ser Pro Ala Leu Val Ser Phe Leu Ala Ser Ser Thr Asp Gly 
            340                 345                 350         

Tyr Leu Ile Glu Asn Gly Ser Leu Tyr Leu Gln Ile Ser Ser Thr Phe 
        355                 360                 365             

Tyr Pro Ile Leu Ser Leu Leu Leu Ile Tyr Arg Asn Cys Leu Gln Gly 
    370                 375                 380                 

Leu Gly Gln Lys Ile Leu Pro Leu Val Ser Ser Phe Ile Glu Leu Ile 
385                 390                 395                 400 

Gly Lys Ile Val Phe Val Val Leu Ile Ile Pro Trp Ala Gly Tyr Lys 
                405                 410                 415     

Gly Val Ile Leu Cys Glu Pro Leu Ile Trp Val Ala Met Thr Val Gln 
            420                 425                 430         

Leu Tyr Phe Ser Leu Phe Arg His Pro Leu Ile Lys Glu Gly Lys Ala 
        435                 440                 445             

Ile Leu Ala Thr Lys Val Gln Ser 
    450                 455     

<210>   4039
<211>   1164
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4039
atggcgaaaa aaccaaaaaa attagaagaa atttcaaaaa aatttggggc agaacgtgaa   60
aaggccttga atgacgctct taaattgatt gagaaagact ttggtaaagg atcaatcatg   120
cgtttgggtg aacgtgcgga gcaaaaggtg caagtgatga gctcaggttc tttagctctt   180
gacattgccc ttggctcagg tggttatcct aagggacgta tcatcgaaat ctatggccca   240
gagtcatctg gtaagacaac ggttgccctt catgcagttg cacaagcgca aaaagaaggt   300
gggattgctg cctttatcga tgcggaacat gcccttgatc cagcttatgc tgcggccctt   360
ggtgtcaata ttgacgaatt gctcttgtct caaccagact caggagagca aggtcttgag   420
attgcgggaa aattgattga ctcaggtgca gttgatcttg tcgtagtcga ctcagttgct   480
gcccttgttc ctcgtgcgga aattgatgga gatatcggag atagccatgt tggtttgcag   540
gctcgtatga tgagccaggc catgcgtaaa cttggcgcct ctatcaataa aaccaaaaca   600
attgccattt ttatcaacca attgcgtgaa aaagttggag tgatgtttgg aaatccagaa   660
acaacaccgg gcggacgtgc tttgaaattc tatgcttcag tccgcttgga tgttcgtggt   720
aatacacaaa ttaagggaac tggtgaccaa aaagaaacca atgtcggtaa agaaactaag   780
attaaggttg taaaaaataa ggtagctcca ccgtttaagg aagccgtagt tgaaattatg   840
tacggagaag gaatttctaa gactggtgag cttttgaaga ttgcaagcga tttggatatt   900
atcaaaaaag caggggcttg gtattcttac aaagatgaaa aaattgggca aggttctgag   960
aatgctaaga aatacttggc agagcaccca gaaatctttg atgaaattga taagcaagtc   1020
cgttctaaat ttggcttgat tgatggagaa gaagtttcag aacaagatac tgaaaacaaa   1080
aaagatgagc caaagaaaga agaagcagtg aatgaagaag ttccgcttga cttaggcgat   1140
gaacttgaaa tcgaaattga agaa                                          1164

<210>   4040
<211>   388
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   recA protein (recA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903799 (0.E+01)

<400>   4040
Met Ala Lys Lys Pro Lys Lys Leu Glu Glu Ile Ser Lys Lys Phe Gly 
1               5                   10                  15      

Ala Glu Arg Glu Lys Ala Leu Asn Asp Ala Leu Lys Leu Ile Glu Lys 
            20                  25                  30          

Asp Phe Gly Lys Gly Ser Ile Met Arg Leu Gly Glu Arg Ala Glu Gln 
        35                  40                  45              

Lys Val Gln Val Met Ser Ser Gly Ser Leu Ala Leu Asp Ile Ala Leu 
    50                  55                  60                  

Gly Ser Gly Gly Tyr Pro Lys Gly Arg Ile Ile Glu Ile Tyr Gly Pro 
65                  70                  75                  80  

Glu Ser Ser Gly Lys Thr Thr Val Ala Leu His Ala Val Ala Gln Ala 
                85                  90                  95      

Gln Lys Glu Gly Gly Ile Ala Ala Phe Ile Asp Ala Glu His Ala Leu 
            100                 105                 110         

Asp Pro Ala Tyr Ala Ala Ala Leu Gly Val Asn Ile Asp Glu Leu Leu 
        115                 120                 125             

Leu Ser Gln Pro Asp Ser Gly Glu Gln Gly Leu Glu Ile Ala Gly Lys 
    130                 135                 140                 

Leu Ile Asp Ser Gly Ala Val Asp Leu Val Val Val Asp Ser Val Ala 
145                 150                 155                 160 

Ala Leu Val Pro Arg Ala Glu Ile Asp Gly Asp Ile Gly Asp Ser His 
                165                 170                 175     

Val Gly Leu Gln Ala Arg Met Met Ser Gln Ala Met Arg Lys Leu Gly 
            180                 185                 190         

Ala Ser Ile Asn Lys Thr Lys Thr Ile Ala Ile Phe Ile Asn Gln Leu 
        195                 200                 205             

Arg Glu Lys Val Gly Val Met Phe Gly Asn Pro Glu Thr Thr Pro Gly 
    210                 215                 220                 

Gly Arg Ala Leu Lys Phe Tyr Ala Ser Val Arg Leu Asp Val Arg Gly 
225                 230                 235                 240 

Asn Thr Gln Ile Lys Gly Thr Gly Asp Gln Lys Glu Thr Asn Val Gly 
                245                 250                 255     

Lys Glu Thr Lys Ile Lys Val Val Lys Asn Lys Val Ala Pro Pro Phe 
            260                 265                 270         

Lys Glu Ala Val Val Glu Ile Met Tyr Gly Glu Gly Ile Ser Lys Thr 
        275                 280                 285             

Gly Glu Leu Leu Lys Ile Ala Ser Asp Leu Asp Ile Ile Lys Lys Ala 
    290                 295                 300                 

Gly Ala Trp Tyr Ser Tyr Lys Asp Glu Lys Ile Gly Gln Gly Ser Glu 
305                 310                 315                 320 

Asn Ala Lys Lys Tyr Leu Ala Glu His Pro Glu Ile Phe Asp Glu Ile 
                325                 330                 335     

Asp Lys Gln Val Arg Ser Lys Phe Gly Leu Ile Asp Gly Glu Glu Val 
            340                 345                 350         

Ser Glu Gln Asp Thr Glu Asn Lys Lys Asp Glu Pro Lys Lys Glu Glu 
        355                 360                 365             

Ala Val Asn Glu Glu Val Pro Leu Asp Leu Gly Asp Glu Leu Glu Ile 
    370                 375                 380                 

Glu Ile Glu Glu 
385             

<210>   4041
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4041
atgaaagcag aaatcattgc tgttggaaca gagattttga cagggcagat tgtcaacacc   60
aatgcccagt ttttgtcgga aaaactagct gagattgggg tagatgtata ttttcagacg   120
gctgtaggag acaatgaagt tcgtctcttg tctttgcttg agattgccag tcaacgtagc   180
agtctggtga ttttgacagg cggtttgggg ccaactgagg acgacctaac caaacaaacc   240
ctagctaaat ttttagggaa agcattagtc tttgatcctc aggctcagga gaagttggat   300
atctttttta ccctgcgacc agactatgcc cgaacaccga ataacgaaag acaagctcaa   360
attgtagaag gagcgattcc actgccaaac gaaacaggac tggctgttgg aggaaaatta   420
gaagtagacg gagtgaccta tgtcgtcctt ccaggtccgc caagtgaatt gaaacccatg   480
gtcttaaacc aacttctacc caagttgatg acagggagca agctgtattc ccgagttctt   540
cgtttctttg ggattggcga gagccagttg gttacgattt tggctgattt aattgataat   600
cagatcgatc ctaccttggc cccttatgcc aagacaggag aagtcactct acgtctgtca   660
acaaaggcta gcagtcaaga agaggcgaat caagcgctgg atatcttgga aaatcaaatc   720
ttggactgcc agactttcga aggaatttct ttacgagact tttgctatgg ttatggggaa   780
gaaactagtt tagccagcat tgtggtagaa gaactgaaaa ggcaagggaa aaccatcgcg   840
gctgcagaga gtttgacggc aggtcttttc caagctaccg tggcgaattt ttctggagtt   900
tcaagtatat ttaagggtgg ttttgtgacc tatagcttgg aggaaaaatc aaggatgttg   960
gatattcctg ccaagaattt ggaagaacat ggtgtggtgt ctgaatttac agctcagaag   1020
atggctgagc aggcacgaag caagacccag tctgattttg gaattagttt gactggagtg   1080
gcaggaccag atagcctaga aggacaccca gttgggacag tcttcatagg cttggcgcaa   1140
gatcaaggaa ctgaggttat caaggttaat attggaggca gaagccgagc agatgtacgt   1200
cacattgcgg ttatgcatgc ctttaaccta gttcgcaagg ctttattaag tgac         1254

<210>   4042
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence/damage-inducible protein CinA
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903800 (0.E+01)

<400>   4042
Met Lys Ala Glu Ile Ile Ala Val Gly Thr Glu Ile Leu Thr Gly Gln 
1               5                   10                  15      

Ile Val Asn Thr Asn Ala Gln Phe Leu Ser Glu Lys Leu Ala Glu Ile 
            20                  25                  30          

Gly Val Asp Val Tyr Phe Gln Thr Ala Val Gly Asp Asn Glu Val Arg 
        35                  40                  45              

Leu Leu Ser Leu Leu Glu Ile Ala Ser Gln Arg Ser Ser Leu Val Ile 
    50                  55                  60                  

Leu Thr Gly Gly Leu Gly Pro Thr Glu Asp Asp Leu Thr Lys Gln Thr 
65                  70                  75                  80  

Leu Ala Lys Phe Leu Gly Lys Ala Leu Val Phe Asp Pro Gln Ala Gln 
                85                  90                  95      

Glu Lys Leu Asp Ile Phe Phe Thr Leu Arg Pro Asp Tyr Ala Arg Thr 
            100                 105                 110         

Pro Asn Asn Glu Arg Gln Ala Gln Ile Val Glu Gly Ala Ile Pro Leu 
        115                 120                 125             

Pro Asn Glu Thr Gly Leu Ala Val Gly Gly Lys Leu Glu Val Asp Gly 
    130                 135                 140                 

Val Thr Tyr Val Val Leu Pro Gly Pro Pro Ser Glu Leu Lys Pro Met 
145                 150                 155                 160 

Val Leu Asn Gln Leu Leu Pro Lys Leu Met Thr Gly Ser Lys Leu Tyr 
                165                 170                 175     

Ser Arg Val Leu Arg Phe Phe Gly Ile Gly Glu Ser Gln Leu Val Thr 
            180                 185                 190         

Ile Leu Ala Asp Leu Ile Asp Asn Gln Ile Asp Pro Thr Leu Ala Pro 
        195                 200                 205             

Tyr Ala Lys Thr Gly Glu Val Thr Leu Arg Leu Ser Thr Lys Ala Ser 
    210                 215                 220                 

Ser Gln Glu Glu Ala Asn Gln Ala Leu Asp Ile Leu Glu Asn Gln Ile 
225                 230                 235                 240 

Leu Asp Cys Gln Thr Phe Glu Gly Ile Ser Leu Arg Asp Phe Cys Tyr 
                245                 250                 255     

Gly Tyr Gly Glu Glu Thr Ser Leu Ala Ser Ile Val Val Glu Glu Leu 
            260                 265                 270         


Lys Arg Gln Gly Lys Thr Ile Ala Ala Ala Glu Ser Leu Thr Ala Gly 
        275                 280                 285             

Leu Phe Gln Ala Thr Val Ala Asn Phe Ser Gly Val Ser Ser Ile Phe 
    290                 295                 300                 

Lys Gly Gly Phe Val Thr Tyr Ser Leu Glu Glu Lys Ser Arg Met Leu 
305                 310                 315                 320 

Asp Ile Pro Ala Lys Asn Leu Glu Glu His Gly Val Val Ser Glu Phe 
                325                 330                 335     

Thr Ala Gln Lys Met Ala Glu Gln Ala Arg Ser Lys Thr Gln Ser Asp 
            340                 345                 350         

Phe Gly Ile Ser Leu Thr Gly Val Ala Gly Pro Asp Ser Leu Glu Gly 
        355                 360                 365             

His Pro Val Gly Thr Val Phe Ile Gly Leu Ala Gln Asp Gln Gly Thr 
    370                 375                 380                 

Glu Val Ile Lys Val Asn Ile Gly Gly Arg Ser Arg Ala Asp Val Arg 
385                 390                 395                 400 

His Ile Ala Val Met His Ala Phe Asn Leu Val Arg Lys Ala Leu Leu 
                405                 410                 415     

Ser Asp 
        

<210>   4043
<211>   1014
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4043
atggttaaaa aaattattgg aatggtgcta gctttacttt ctgtaactgt agtaggagta   60
ggtgtttttg cttatactat ttatcaacaa gggacagaaa ccttagctaa aacctataaa   120
aaaatcggtg aagaaaccaa ggttattgaa gcgactgaac ctctaaccat tctgttaatg   180
ggagtggaca ccggaaatgt tgaacgaact gaaacttggg tcggtagaag tgatagcatg   240
atcttgatga cagtgaatcc taaaacgaaa aaaacaacaa tgatgagttt agagcgggat   300
attctgacgc gcattgaatc agggaatggt caggctcatg aagcgaaact gaactcagca   360
tatgcagatg gtggagcaga gcttgctata gaaaccattc aaaaaatgat gaatatccat   420
attgatcgct atgtgatggt caatatgaga ggattgcaaa aactagtgga tgcagtagga   480
ggtattacag tcaataatat cctaggtttc ccaatttcta tcagtgacca agaagaattt   540
aatactattt ctatcggtgt tggggagcaa catattgggg gagaagaagc cctagtctat   600
gcacgaatgc gttaccaaga tcctgagggg gattatggtc gtcaaaaacg tcaacgtgaa   660
gttattcaaa aagtcatgga aaaagctctc agtttaaata gcattggtca ttatcaagag   720
attctaaaag ctttgagtga caatatgcag accaatattg atttgtctgc aaaaagtatc   780
cctaacttgc taggctataa agattcattt aaaaccattg aaactcagca gttgcagggt   840
gaaggagaga tacttcaagg tgtttcttac cagattgttt cgagagcaca tatgttggaa   900
atgcaaaatc tactccgacg ttctttggga caagaagaag ttactcagct tgaaaccaat   960
gcggttttat ttgaagattt atttggcaga gcacctgttg gtgatgaaga taat         1014

<210>   4044
<211>   338
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903801 (0.E+01)

<400>   4044
Met Val Lys Lys Ile Ile Gly Met Val Leu Ala Leu Leu Ser Val Thr 
1               5                   10                  15      

Val Val Gly Val Gly Val Phe Ala Tyr Thr Ile Tyr Gln Gln Gly Thr 
            20                  25                  30          

Glu Thr Leu Ala Lys Thr Tyr Lys Lys Ile Gly Glu Glu Thr Lys Val 
        35                  40                  45              

Ile Glu Ala Thr Glu Pro Leu Thr Ile Leu Leu Met Gly Val Asp Thr 
    50                  55                  60                  

Gly Asn Val Glu Arg Thr Glu Thr Trp Val Gly Arg Ser Asp Ser Met 
65                  70                  75                  80  

Ile Leu Met Thr Val Asn Pro Lys Thr Lys Lys Thr Thr Met Met Ser 
                85                  90                  95      

Leu Glu Arg Asp Ile Leu Thr Arg Ile Glu Ser Gly Asn Gly Gln Ala 
            100                 105                 110         

His Glu Ala Lys Leu Asn Ser Ala Tyr Ala Asp Gly Gly Ala Glu Leu 
        115                 120                 125             

Ala Ile Glu Thr Ile Gln Lys Met Met Asn Ile His Ile Asp Arg Tyr 
    130                 135                 140                 

Val Met Val Asn Met Arg Gly Leu Gln Lys Leu Val Asp Ala Val Gly 
145                 150                 155                 160 

Gly Ile Thr Val Asn Asn Ile Leu Gly Phe Pro Ile Ser Ile Ser Asp 
                165                 170                 175     

Gln Glu Glu Phe Asn Thr Ile Ser Ile Gly Val Gly Glu Gln His Ile 
            180                 185                 190         

Gly Gly Glu Glu Ala Leu Val Tyr Ala Arg Met Arg Tyr Gln Asp Pro 
        195                 200                 205             

Glu Gly Asp Tyr Gly Arg Gln Lys Arg Gln Arg Glu Val Ile Gln Lys 
    210                 215                 220                 

Val Met Glu Lys Ala Leu Ser Leu Asn Ser Ile Gly His Tyr Gln Glu 
225                 230                 235                 240 

Ile Leu Lys Ala Leu Ser Asp Asn Met Gln Thr Asn Ile Asp Leu Ser 
                245                 250                 255     

Ala Lys Ser Ile Pro Asn Leu Leu Gly Tyr Lys Asp Ser Phe Lys Thr 
            260                 265                 270         

Ile Glu Thr Gln Gln Leu Gln Gly Glu Gly Glu Ile Leu Gln Gly Val 
        275                 280                 285             


Ser Tyr Gln Ile Val Ser Arg Ala His Met Leu Glu Met Gln Asn Leu 
    290                 295                 300                 

Leu Arg Arg Ser Leu Gly Gln Glu Glu Val Thr Gln Leu Glu Thr Asn 
305                 310                 315                 320 

Ala Val Leu Phe Glu Asp Leu Phe Gly Arg Ala Pro Val Gly Asp Glu 
                325                 330                 335     

Asp Asn 
        

<210>   4045
<211>   516
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4045
atggagtatg aattgctcat tagggaagca gagcccaaag atgcagctga attagtggcc   60
tttttaaatc gtgtgagttt ggagacagac tttaccagcc tagacggaga tggtattctc   120
ttgactagtg aggagatgga aatattcctc aacaagcaag ctagttcgga caatcagata   180
accttacttg cattcttaaa tggcaaaatt gctggtattg taaatattac agctgatcag   240
cgtaagagag tccgtcatat tggagatctc ttcattgtga ttggaaaaag atattggaat   300
aatggcttgg gaagtttgtt gctagaagaa gcgatagagt gggcacaagc aagtggcatt   360
ctgcgtcgtc tccaactgac tgtccaaact cgtaatcaag cagcagtcca tctttatcaa   420

aagcatggct ttgtcattga aggtagccaa gagcgtgggg catatataga agaagggaaa   480
tttatcgatg tttacttgat gggtaaactg ataggt                             516

<210>   4046
<211>   172
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, GNAT family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903802 (4.E-94)

<400>   4046
Met Glu Tyr Glu Leu Leu Ile Arg Glu Ala Glu Pro Lys Asp Ala Ala 
1               5                   10                  15      

Glu Leu Val Ala Phe Leu Asn Arg Val Ser Leu Glu Thr Asp Phe Thr 
            20                  25                  30          

Ser Leu Asp Gly Asp Gly Ile Leu Leu Thr Ser Glu Glu Met Glu Ile 
        35                  40                  45              

Phe Leu Asn Lys Gln Ala Ser Ser Asp Asn Gln Ile Thr Leu Leu Ala 
    50                  55                  60                  

Phe Leu Asn Gly Lys Ile Ala Gly Ile Val Asn Ile Thr Ala Asp Gln 
65                  70                  75                  80  

Arg Lys Arg Val Arg His Ile Gly Asp Leu Phe Ile Val Ile Gly Lys 
                85                  90                  95      

Arg Tyr Trp Asn Asn Gly Leu Gly Ser Leu Leu Leu Glu Glu Ala Ile 
            100                 105                 110         

Glu Trp Ala Gln Ala Ser Gly Ile Leu Arg Arg Leu Gln Leu Thr Val 
        115                 120                 125             

Gln Thr Arg Asn Gln Ala Ala Val His Leu Tyr Gln Lys His Gly Phe 
    130                 135                 140                 

Val Ile Glu Gly Ser Gln Glu Arg Gly Ala Tyr Ile Glu Glu Gly Lys 
145                 150                 155                 160 

Phe Ile Asp Val Tyr Leu Met Gly Lys Leu Ile Gly 
                165                 170         

<210>   4047
<211>   441
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4047
atgtacacaa aaaatgaaga agagttgcaa gccttagggg agcgtttggg ccatctatta   60
gcaaagaatg atgttttaat cttaactgga gaactgggtg caggtaaaac gacctttact   120
aaaggacttg caaaaggatt acagatttct caaatgatta aaagtcccac ctatactatc   180
gtgagagagt atgaaggtcg acttccactt tatcacctag atgtttatcg tattgaagga   240
gatgctgatt ctatcgactt ggatgagttt atctttggtg gcggcgtgac tgttattgag   300
tggggaaatc tcttaggaga tgccttgcca gatgcttatt tagaattgga aattctaaaa   360
gaagcagatg gacgccgttt aaattttcag gcaaagggtt tgcgtgctga gaaattgtta   420
gaggagcttc aatatggagt a                                             441

<210>   4048
<211>   147
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903803 (4.E-81)

<400>   4048
Met Tyr Thr Lys Asn Glu Glu Glu Leu Gln Ala Leu Gly Glu Arg Leu 
1               5                   10                  15      

Gly His Leu Leu Ala Lys Asn Asp Val Leu Ile Leu Thr Gly Glu Leu 
            20                  25                  30          

Gly Ala Gly Lys Thr Thr Phe Thr Lys Gly Leu Ala Lys Gly Leu Gln 
        35                  40                  45              

Ile Ser Gln Met Ile Lys Ser Pro Thr Tyr Thr Ile Val Arg Glu Tyr 
    50                  55                  60                  

Glu Gly Arg Leu Pro Leu Tyr His Leu Asp Val Tyr Arg Ile Glu Gly 
65                  70                  75                  80  

Asp Ala Asp Ser Ile Asp Leu Asp Glu Phe Ile Phe Gly Gly Gly Val 
                85                  90                  95      

Thr Val Ile Glu Trp Gly Asn Leu Leu Gly Asp Ala Leu Pro Asp Ala 
            100                 105                 110         

Tyr Leu Glu Leu Glu Ile Leu Lys Glu Ala Asp Gly Arg Arg Leu Asn 
        115                 120                 125             

Phe Gln Ala Lys Gly Leu Arg Ala Glu Lys Leu Leu Glu Glu Leu Gln 
    130                 135                 140                 

Tyr Gly Val 
145         

<210>   4049
<211>   618
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4049
atgaaatcaa tgagaatctt atttttgtta gctttaattc aaatcagttt gagtagctgt   60
ttcctatgga aggaatgcat cttgtccttt aaacaaagta cagctttttt catcggaagc   120
atggttttcg tttcaggaat ctgtgctgga gtaaattatc tttatacccg taagcaagaa   180
gtccatagtg tcctagccag taagaagtcg gtgaagcttt tttacagtat gttactctta   240
attaatttgt taggagctgt tcttgttttg tcagataact tgttcatcaa aaatacgctg   300
cagcaagaat tagttgactt tttattgcca tccttctttt tcctatttgg gctagatttg   360
ctgatttttt tacccttgaa aaaatacgtg cgcgattttc ttgctatgct ggacagaaaa   420
aagacagtgt tggtgactat tttagcaaca cttcttttct taagaaatcc aatgaccatt   480
gtctcacttc tgatttatat tggactgggc ttgttttttg cagcctatct tgtcccaaat   540
tcggttaaga aggaagtttc cttttatggt catattttcc gagatcttgt attggtcatt   600
gttacgctca ttttcttt                                                 618

<210>   4050
<211>   206
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903804 (e-112)

<400>   4050
Met Lys Ser Met Arg Ile Leu Phe Leu Leu Ala Leu Ile Gln Ile Ser 
1               5                   10                  15      

Leu Ser Ser Cys Phe Leu Trp Lys Glu Cys Ile Leu Ser Phe Lys Gln 
            20                  25                  30          

Ser Thr Ala Phe Phe Ile Gly Ser Met Val Phe Val Ser Gly Ile Cys 
        35                  40                  45              

Ala Gly Val Asn Tyr Leu Tyr Thr Arg Lys Gln Glu Val His Ser Val 
    50                  55                  60                  

Leu Ala Ser Lys Lys Ser Val Lys Leu Phe Tyr Ser Met Leu Leu Leu 
65                  70                  75                  80  

Ile Asn Leu Leu Gly Ala Val Leu Val Leu Ser Asp Asn Leu Phe Ile 
                85                  90                  95      

Lys Asn Thr Leu Gln Gln Glu Leu Val Asp Phe Leu Leu Pro Ser Phe 
            100                 105                 110         

Phe Phe Leu Phe Gly Leu Asp Leu Leu Ile Phe Leu Pro Leu Lys Lys 
        115                 120                 125             

Tyr Val Arg Asp Phe Leu Ala Met Leu Asp Arg Lys Lys Thr Val Leu 
    130                 135                 140                 

Val Thr Ile Leu Ala Thr Leu Leu Phe Leu Arg Asn Pro Met Thr Ile 
145                 150                 155                 160 

Val Ser Leu Leu Ile Tyr Ile Gly Leu Gly Leu Phe Phe Ala Ala Tyr 
                165                 170                 175     

Leu Val Pro Asn Ser Val Lys Lys Glu Val Ser Phe Tyr Gly His Ile 
            180                 185                 190         

Phe Arg Asp Leu Val Leu Val Ile Val Thr Leu Ile Phe Phe 
        195                 200                 205     

<210>   4051
<211>   135
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4051
gtgcgagaca aaacaaccac ccgtttgacg gattttcatg atttcaaatt tatattcttc   60
gaaaatctct tcaaatcacg tcagctctat ctgcaatctc aaaacactgt tttgagcaac   120
ctgtggctag ctacc                                                    135

<210>   4052
<211>   45
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4052
Met Arg Asp Lys Thr Thr Thr Arg Leu Thr Asp Phe His Asp Phe Lys 
1               5                   10                  15      

Phe Ile Phe Phe Glu Asn Leu Phe Lys Ser Arg Gln Leu Tyr Leu Gln 
            20                  25                  30          

Ser Gln Asn Thr Val Leu Ser Asn Leu Trp Leu Ala Thr 
        35                  40                  45  

<210>   4053
<211>   861
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4053
atgaatacac tcgcagagaa attcagattg aaaagaaaag agttgagact ctcccaacaa   60
actcttgcag aaggaatttg tgaacaaagc cagattagta aaattgaaag aggtcatttt   120
attccctccg cagacttgtt attcaaactc tctcaacgac ttgaagtccc tttggattac   180
tttttcaatg aacaaatcga agttaagtct aacctctcta atttcaaaca tctatctgct   240
cgcctattag atgacagaaa ttatgacgat ttagaatatc tttataaaat agaagtagaa   300
cgaagcactt ttctaacatt agaagaccga acttaccttg aatggattaa atctataatt   360
gacttctatc aatatgacag taagtgtgag gcaatttcgt cattggaaaa tatattatta   420
aaagtctctt caaatactct gatttattta aaggcgttga atactctatc taatttctat   480
tccttagtgg gtcgtgaaca agaatatgag gcaaactact ctcatttaat agagttgtat   540
cagacaaaaa atttggacca tcaagagttt ttatttggct acatcagagt tcgttacaac   600
tacgctcact acctagtatc aaaggaaaaa tataatgaag ccatccaaga agctcttgaa   660
acgattgaac tctgtaaaca aagacagaca agctaccaat tggctcctct acttattctt   720
gtaggaaatg ctggagccaa atttctagac agagaacaag tcaaaaatta ttatatagaa   780
gcaagagagt tatgtaagat ttataacaat cctttaatgt tgatgaagat agaaaattat   840
ttgaaggaac tagatactgt t                                             861

<210>   4054
<211>   287
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator PlcR, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903805 (e-164)

<400>   4054
Met Asn Thr Leu Ala Glu Lys Phe Arg Leu Lys Arg Lys Glu Leu Arg 
1               5                   10                  15      

Leu Ser Gln Gln Thr Leu Ala Glu Gly Ile Cys Glu Gln Ser Gln Ile 
            20                  25                  30          

Ser Lys Ile Glu Arg Gly His Phe Ile Pro Ser Ala Asp Leu Leu Phe 
        35                  40                  45              

Lys Leu Ser Gln Arg Leu Glu Val Pro Leu Asp Tyr Phe Phe Asn Glu 
    50                  55                  60                  

Gln Ile Glu Val Lys Ser Asn Leu Ser Asn Phe Lys His Leu Ser Ala 
65                  70                  75                  80  

Arg Leu Leu Asp Asp Arg Asn Tyr Asp Asp Leu Glu Tyr Leu Tyr Lys 
                85                  90                  95      


Ile Glu Val Glu Arg Ser Thr Phe Leu Thr Leu Glu Asp Arg Thr Tyr 
            100                 105                 110         

Leu Glu Trp Ile Lys Ser Ile Ile Asp Phe Tyr Gln Tyr Asp Ser Lys 
        115                 120                 125             

Cys Glu Ala Ile Ser Ser Leu Glu Asn Ile Leu Leu Lys Val Ser Ser 
    130                 135                 140                 

Asn Thr Leu Ile Tyr Leu Lys Ala Leu Asn Thr Leu Ser Asn Phe Tyr 
145                 150                 155                 160 

Ser Leu Val Gly Arg Glu Gln Glu Tyr Glu Ala Asn Tyr Ser His Leu 
                165                 170                 175     

Ile Glu Leu Tyr Gln Thr Lys Asn Leu Asp His Gln Glu Phe Leu Phe 
            180                 185                 190         

Gly Tyr Ile Arg Val Arg Tyr Asn Tyr Ala His Tyr Leu Val Ser Lys 
        195                 200                 205             

Glu Lys Tyr Asn Glu Ala Ile Gln Glu Ala Leu Glu Thr Ile Glu Leu 
    210                 215                 220                 

Cys Lys Gln Arg Gln Thr Ser Tyr Gln Leu Ala Pro Leu Leu Ile Leu 
225                 230                 235                 240 

Val Gly Asn Ala Gly Ala Lys Phe Leu Asp Arg Glu Gln Val Lys Asn 
                245                 250                 255     

Tyr Tyr Ile Glu Ala Arg Glu Leu Cys Lys Ile Tyr Asn Asn Pro Leu 
            260                 265                 270         

Met Leu Met Lys Ile Glu Asn Tyr Leu Lys Glu Leu Asp Thr Val 
        275                 280                 285         

<210>   4055
<211>   168
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4055
atgagaaaaa aacgtggaat taaaaaatta gttacatttg cattgctagg tgtttttatg   60
tttagtaata caattcctta ccaacagttt attcagaaga ataaacaatt ggagattcga   120
gtgcaatcgc aaaagaagtc caatggtctt gatgttggga aggcggat                168

<210>   4056
<211>   56
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903806 (2.E-27)

<400>   4056
Met Arg Lys Lys Arg Gly Ile Lys Lys Leu Val Thr Phe Ala Leu Leu 
1               5                   10                  15      

Gly Val Phe Met Phe Ser Asn Thr Ile Pro Tyr Gln Gln Phe Ile Gln 
            20                  25                  30          

Lys Asn Lys Gln Leu Glu Ile Arg Val Gln Ser Gln Lys Lys Ser Asn 
        35                  40                  45              

Gly Leu Asp Val Gly Lys Ala Asp 
    50                  55      

<210>   4057
<211>   222
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4057
atgaccaact ttaattcaaa cgaaaaattt tgtggaaaaa gtttaaaatc attgtctgct   60
gatgaaatga gtttaattta tggtgcatct gatggtgcag agccacgttg gacgcctact   120
cctattattt tgaaatcagc tgcagctagc tcgaaagtat gcattagtgc agctgtttct   180
ggtattgggg ggctagttag ctacaataat gattgtttgg gg                      222

<210>   4058
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903807 (5.E-39)

<400>   4058
Met Thr Asn Phe Asn Ser Asn Glu Lys Phe Cys Gly Lys Ser Leu Lys 
1               5                   10                  15      

Ser Leu Ser Ala Asp Glu Met Ser Leu Ile Tyr Gly Ala Ser Asp Gly 
            20                  25                  30          

Ala Glu Pro Arg Trp Thr Pro Thr Pro Ile Ile Leu Lys Ser Ala Ala 
        35                  40                  45              

Ala Ser Ser Lys Val Cys Ile Ser Ala Ala Val Ser Gly Ile Gly Gly 
    50                  55                  60                  

Leu Val Ser Tyr Asn Asn Asp Cys Leu Gly 
65                  70                  

<210>   4059
<211>   186
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4059
atgaaaaatg attttgtaat cggaaagagt ttgaaagaat tatctcttga agaaatgcaa   60
ttggtttatg gtggcacaga tggtgctgac cctagatcaa caattatatg ttctgctaca   120
ttaagtttta ttgcatcata tttggggtca gctcagactc gttgtggcaa agacaacaag   180
aaaaaa                                                              186

<210>   4060
<211>   62
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903808 (1.E-31)

<400>   4060
Met Lys Asn Asp Phe Val Ile Gly Lys Ser Leu Lys Glu Leu Ser Leu 
1               5                   10                  15      

Glu Glu Met Gln Leu Val Tyr Gly Gly Thr Asp Gly Ala Asp Pro Arg 
            20                  25                  30          

Ser Thr Ile Ile Cys Ser Ala Thr Leu Ser Phe Ile Ala Ser Tyr Leu 
        35                  40                  45              

Gly Ser Ala Gln Thr Arg Cys Gly Lys Asp Asn Lys Lys Lys 
    50                  55                  60          

<210>   4061
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4061
atggatagaa caatgaaata tcctatatcc ccagttaaac caaatgtggt cttagataaa   60
gaaacagatg gcggaattgc agataacatt ttattgtaca gt                      102

<210>   4062
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4062
Met Asp Arg Thr Met Lys Tyr Pro Ile Ser Pro Val Lys Pro Asn Val 
1               5                   10                  15      

Val Leu Asp Lys Glu Thr Asp Gly Gly Ile Ala Asp Asn Ile Leu Leu 
            20                  25                  30          

Tyr Ser 
        

<210>   4063
<211>   2988
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   4063
atgaaatata aaattaaaaa tgtgcataaa acattgttta ttaaggaaag atatcaaata   60
ttatctgaac gaaatgataa ttccttaaat aacttttcat taaataattg gcgttctaca   120
atgtcaatta tttctgaaaa aacttttgaa gaaatgttga aattaaataa ttacaataaa   180
aaaatatttt ctaacactgt gaactatgat tataccgagg aacagataag actatattca   240
gaatatgcca aaaattcgga atggtataaa tttgcggagg gttcatttga aatatttaga   300
aaacatcccc aaagaattaa ttttaagaaa gatttttcta gaattttgga accctttatt   360
attaatttgc ttaaattaat caataattat ctagagaata aagaatacga gtggattgac   420
aagaatggaa atattttttc ctctctagta ttttatttag aagatttaat ctatccttgg   480
attgttaaac ctttggtttt agagataaat tcattgcgtg aaaaaggttt acttgaaggg   540
gaatcggagc agcaacggta caaatatttt ataacattgt ttgacaagga agagaatata   600
ttaaattttt ataacaaata tcccgtttta ctgaggcaaa tatcggagtc ttgtcttcgg   660
ttctatactt attttataga aattttatca aatttagaaa atgattttag tgtgctagaa   720
gaagaattag ggctaagggg gaaattaaat gatataaaat ttggaaaggg tgatacacac   780
agccaaggaa aaactgtttt gatactcttc tttgatgacg cgaaaattgt ttacaagcct   840
aaaaatttaa taatcaataa ctcactaaat actattgctg agtatatccg aaaggttgat   900
gaaaaaatta ggataagaat acctcgaact attgcttatt cggatcacag ctatgaagaa   960
tttattgatt atctacctct agagcaaaag aaaaatttac ctgaatatta ttataatttt   1020
ggtgtgcttt tagcatttat atatttattt aatgggagtg atatacattt tgaaaattta   1080
atttcctatg gagatatgcc tgtaataata gactttgaaa caatgttaca gcaacctcta   1140
tttgatgata aaactggtca gagtttgctg gataccctgt ttcacagggt gactcgaact   1200
ttgcttcttc caacagaggg agtaaaaagg gaggatggtc ttgatgttga gatgagtgct   1260
cttacaggaa attttaagaa ggatgctttt aatggtcaag ttttaattaa tttaaatact   1320
gataaggtaa agtttgatat tgggaaaatt gattttgaag gtgggaaaaa cctgcctgtt   1380
cgggatggtg atatagaatt tgataagtat ataaaagatt tcaaaaaagg ttttagggat   1440
ttttatctga tatttgaaga gttaaataaa acagaagaat ttaaaatgct attaaaagca   1500
aacttgtatg gtttaaagac aagggtactt tttagagaca caaatagcta tgcttcagta   1560
ctatcttttt tatatcatcc tgatttttat gaagaaatgt tagatagaga aaaagcattg   1620
gaaaatctct ggagcaataa gttttctaat caaggtattg tagcaagcga atgtgaacaa   1680
atgaggttat tagatattcc gattttttat acagatacaa atatcaatga aatctacgat   1740
gattttggaa atcattttat ttccctacat caattttctg gatatgacta ttttatgaaa   1800
tatttaccta ataataattt ggaaaattta gaaaagcaac ttgatatcat tgaaatttat   1860
tttccaagct ttgatcagcg aaaaaaagga tataaattaa acttatctaa tagaaaaaaa   1920
ctcccaaatg aaagtttagt tactattctg cataatgaag tagaaaatat tgcagactct   1980
ttggttatta ataatattta tgacgaatat ccaatttgga gtatacctgt taattttaaa   2040
ggttctaaat ggtgtcttga acaaacgggt aatgatatgt ataggggtag agctggaata   2100
ttactgttta tgtactatgt aaaattattg aaagataaat catcatatac tcaactgtac   2160
aataaaatgt tatctgcaat tccgccatct gtttctttat ctaagaccac atttggttta   2220
actggggata taggatattt cattgttcta tccattatag aggattacga tacaaatact   2280
ctcgcatgct taaattatat aaagagtgtt ttaactgagc ttgaaaagac tgattttgca   2340
agtgtttcaa acaagtctga ctatattaat ggtcttctac ctttaattaa tacactggta   2400
agatattata ggagaggaat agagaaggaa cgtgttctaa ggctagtatt aagtttaggt   2460
gatacgctat ataatgatgt aagcgagaga gataatagta attttggata tagttttggc   2520
catggactat caggtgtaat ttttacatta aaaaatattt ataaagtgac aagacttaaa   2580
aaatataaag aattaatttt acaactagtt cctagggaga aaatcaaaat tcattctttg   2640
aagtggtgta gtggagaatt tgggacatta gttaatcatc cccaaagtgt tccagaggga   2700
attgtagcta gtttagataa tgatacattt tgccatggaa gtatggccat aataaatttt   2760
tacatcgact acatgaaaga aatggatact agtatggaat tggagtcttt attgtgtagt   2820
gttgtaatga ataaatcaaa agaaggagag tatcgtatcg tccaaacaag caatttccca   2880
gatttttctt tgtatacagg tgtgactggt attgcttata cttttttaag gtatatcgca   2940
ctgaatcaga atgacaaaaa gatagttatc ccctcattac ttgaaatc                2988

<210>   4064
<211>   996
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacteriocin formation protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903809 (0.E+01)

<400>   4064
Met Lys Tyr Lys Ile Lys Asn Val His Lys Thr Leu Phe Ile Lys Glu 
1               5                   10                  15      

Arg Tyr Gln Ile Leu Ser Glu Arg Asn Asp Asn Ser Leu Asn Asn Phe 
            20                  25                  30          

Ser Leu Asn Asn Trp Arg Ser Thr Met Ser Ile Ile Ser Glu Lys Thr 
        35                  40                  45              

Phe Glu Glu Met Leu Lys Leu Asn Asn Tyr Asn Lys Lys Ile Phe Ser 
    50                  55                  60                  

Asn Thr Val Asn Tyr Asp Tyr Thr Glu Glu Gln Ile Arg Leu Tyr Ser 
65                  70                  75                  80  

Glu Tyr Ala Lys Asn Ser Glu Trp Tyr Lys Phe Ala Glu Gly Ser Phe 
                85                  90                  95      

Glu Ile Phe Arg Lys His Pro Gln Arg Ile Asn Phe Lys Lys Asp Phe 
            100                 105                 110         

Ser Arg Ile Leu Glu Pro Phe Ile Ile Asn Leu Leu Lys Leu Ile Asn 
        115                 120                 125             

Asn Tyr Leu Glu Asn Lys Glu Tyr Glu Trp Ile Asp Lys Asn Gly Asn 
    130                 135                 140                 

Ile Phe Ser Ser Leu Val Phe Tyr Leu Glu Asp Leu Ile Tyr Pro Trp 
145                 150                 155                 160 

Ile Val Lys Pro Leu Val Leu Glu Ile Asn Ser Leu Arg Glu Lys Gly 
                165                 170                 175     

Leu Leu Glu Gly Glu Ser Glu Gln Gln Arg Tyr Lys Tyr Phe Ile Thr 
            180                 185                 190         

Leu Phe Asp Lys Glu Glu Asn Ile Leu Asn Phe Tyr Asn Lys Tyr Pro 
        195                 200                 205             

Val Leu Leu Arg Gln Ile Ser Glu Ser Cys Leu Arg Phe Tyr Thr Tyr 
    210                 215                 220                 

Phe Ile Glu Ile Leu Ser Asn Leu Glu Asn Asp Phe Ser Val Leu Glu 
225                 230                 235                 240 

Glu Glu Leu Gly Leu Arg Gly Lys Leu Asn Asp Ile Lys Phe Gly Lys 
                245                 250                 255     

Gly Asp Thr His Ser Gln Gly Lys Thr Val Leu Ile Leu Phe Phe Asp 
            260                 265                 270         

Asp Ala Lys Ile Val Tyr Lys Pro Lys Asn Leu Ile Ile Asn Asn Ser 
        275                 280                 285             

Leu Asn Thr Ile Ala Glu Tyr Ile Arg Lys Val Asp Glu Lys Ile Arg 
    290                 295                 300                 

Ile Arg Ile Pro Arg Thr Ile Ala Tyr Ser Asp His Ser Tyr Glu Glu 
305                 310                 315                 320 

Phe Ile Asp Tyr Leu Pro Leu Glu Gln Lys Lys Asn Leu Pro Glu Tyr 
                325                 330                 335     

Tyr Tyr Asn Phe Gly Val Leu Leu Ala Phe Ile Tyr Leu Phe Asn Gly 
            340                 345                 350         

Ser Asp Ile His Phe Glu Asn Leu Ile Ser Tyr Gly Asp Met Pro Val 
        355                 360                 365             

Ile Ile Asp Phe Glu Thr Met Leu Gln Gln Pro Leu Phe Asp Asp Lys 
    370                 375                 380                 

Thr Gly Gln Ser Leu Leu Asp Thr Leu Phe His Arg Val Thr Arg Thr 
385                 390                 395                 400 

Leu Leu Leu Pro Thr Glu Gly Val Lys Arg Glu Asp Gly Leu Asp Val 
                405                 410                 415     

Glu Met Ser Ala Leu Thr Gly Asn Phe Lys Lys Asp Ala Phe Asn Gly 
            420                 425                 430         

Gln Val Leu Ile Asn Leu Asn Thr Asp Lys Val Lys Phe Asp Ile Gly 
        435                 440                 445             

Lys Ile Asp Phe Glu Gly Gly Lys Asn Leu Pro Val Arg Asp Gly Asp 
    450                 455                 460                 

Ile Glu Phe Asp Lys Tyr Ile Lys Asp Phe Lys Lys Gly Phe Arg Asp 
465                 470                 475                 480 

Phe Tyr Leu Ile Phe Glu Glu Leu Asn Lys Thr Glu Glu Phe Lys Met 
                485                 490                 495     

Leu Leu Lys Ala Asn Leu Tyr Gly Leu Lys Thr Arg Val Leu Phe Arg 
            500                 505                 510         

Asp Thr Asn Ser Tyr Ala Ser Val Leu Ser Phe Leu Tyr His Pro Asp 
        515                 520                 525             

Phe Tyr Glu Glu Met Leu Asp Arg Glu Lys Ala Leu Glu Asn Leu Trp 
    530                 535                 540                 

Ser Asn Lys Phe Ser Asn Gln Gly Ile Val Ala Ser Glu Cys Glu Gln 
545                 550                 555                 560 

Met Arg Leu Leu Asp Ile Pro Ile Phe Tyr Thr Asp Thr Asn Ile Asn 
                565                 570                 575     

Glu Ile Tyr Asp Asp Phe Gly Asn His Phe Ile Ser Leu His Gln Phe 
            580                 585                 590         

Ser Gly Tyr Asp Tyr Phe Met Lys Tyr Leu Pro Asn Asn Asn Leu Glu 
        595                 600                 605             

Asn Leu Glu Lys Gln Leu Asp Ile Ile Glu Ile Tyr Phe Pro Ser Phe 
    610                 615                 620                 

Asp Gln Arg Lys Lys Gly Tyr Lys Leu Asn Leu Ser Asn Arg Lys Lys 
625                 630                 635                 640 

Leu Pro Asn Glu Ser Leu Val Thr Ile Leu His Asn Glu Val Glu Asn 
                645                 650                 655     

Ile Ala Asp Ser Leu Val Ile Asn Asn Ile Tyr Asp Glu Tyr Pro Ile 
            660                 665                 670         

Trp Ser Ile Pro Val Asn Phe Lys Gly Ser Lys Trp Cys Leu Glu Gln 
        675                 680                 685             

Thr Gly Asn Asp Met Tyr Arg Gly Arg Ala Gly Ile Leu Leu Phe Met 
    690                 695                 700                 

Tyr Tyr Val Lys Leu Leu Lys Asp Lys Ser Ser Tyr Thr Gln Leu Tyr 
705                 710                 715                 720 

Asn Lys Met Leu Ser Ala Ile Pro Pro Ser Val Ser Leu Ser Lys Thr 
                725                 730                 735     

Thr Phe Gly Leu Thr Gly Asp Ile Gly Tyr Phe Ile Val Leu Ser Ile 
            740                 745                 750         

Ile Glu Asp Tyr Asp Thr Asn Thr Leu Ala Cys Leu Asn Tyr Ile Lys 
        755                 760                 765             

Ser Val Leu Thr Glu Leu Glu Lys Thr Asp Phe Ala Ser Val Ser Asn 
    770                 775                 780                 

Lys Ser Asp Tyr Ile Asn Gly Leu Leu Pro Leu Ile Asn Thr Leu Val 
785                 790                 795                 800 

Arg Tyr Tyr Arg Arg Gly Ile Glu Lys Glu Arg Val Leu Arg Leu Val 
                805                 810                 815     

Leu Ser Leu Gly Asp Thr Leu Tyr Asn Asp Val Ser Glu Arg Asp Asn 
            820                 825                 830         

Ser Asn Phe Gly Tyr Ser Phe Gly His Gly Leu Ser Gly Val Ile Phe 
        835                 840                 845             

Thr Leu Lys Asn Ile Tyr Lys Val Thr Arg Leu Lys Lys Tyr Lys Glu 
    850                 855                 860                 

Leu Ile Leu Gln Leu Val Pro Arg Glu Lys Ile Lys Ile His Ser Leu 
865                 870                 875                 880 

Lys Trp Cys Ser Gly Glu Phe Gly Thr Leu Val Asn His Pro Gln Ser 
                885                 890                 895     

Val Pro Glu Gly Ile Val Ala Ser Leu Asp Asn Asp Thr Phe Cys His 
            900                 905                 910         

Gly Ser Met Ala Ile Ile Asn Phe Tyr Ile Asp Tyr Met Lys Glu Met 
        915                 920                 925             

Asp Thr Ser Met Glu Leu Glu Ser Leu Leu Cys Ser Val Val Met Asn 
    930                 935                 940                 

Lys Ser Lys Glu Gly Glu Tyr Arg Ile Val Gln Thr Ser Asn Phe Pro 
945                 950                 955                 960 

Asp Phe Ser Leu Tyr Thr Gly Val Thr Gly Ile Ala Tyr Thr Phe Leu 
                965                 970                 975     

Arg Tyr Ile Ala Leu Asn Gln Asn Asp Lys Lys Ile Val Ile Pro Ser 
            980                 985                 990         

Leu Leu Glu Ile 
        995     

<210>   4065
<211>   702
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4065
atgaataaaa tatttatata tgcaggagtg cgaaatcata actctaagac tttagagtat   60
actaagagac tttcaagtat catttctagt agaaataatg ttgatatatc tttcaggaca   120
cctttcaatt cagagctaga aatatctaat tctgattcag aagagttgtt taagaaagga   180
attgataggc aaagtaatgc tgatgatgga ggtgttataa aaaaagagtt attagagtct   240
gatattataa ttatctcttc tcctgtatat ttacaaaacg tatctgtgga cacaaaaaac   300
tttattgaaa ggattggggg gtggagccat ctttttcgat tagctggaaa gtttgttgta   360
acattagatg ttgctgagag taacggctct gataatgtgt cagaatatct tagagatata   420
ttttcatata tgggaggaca gatattacac caagtttcaa ttaccaattc actcaaagat   480
attgcagagg ctcagttgat ggaggcaact tataaaattg aagatgtact tgaagggaaa   540
attaagtaca aaacaacgga ttatcaagaa agagcttacc agacattaaa attaatttta   600
gaaaattatg attccgaaca ttttgagaag atgtattggg agaaaaaacg cctttttgaa   660
gctaatagtt tagaggaatg gtattatgtt gaaaatatta aa                      702

<210>   4066
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903810 (e-132)

<400>   4066
Met Asn Lys Ile Phe Ile Tyr Ala Gly Val Arg Asn His Asn Ser Lys 
1               5                   10                  15      

Thr Leu Glu Tyr Thr Lys Arg Leu Ser Ser Ile Ile Ser Ser Arg Asn 
            20                  25                  30          

Asn Val Asp Ile Ser Phe Arg Thr Pro Phe Asn Ser Glu Leu Glu Ile 
        35                  40                  45              

Ser Asn Ser Asp Ser Glu Glu Leu Phe Lys Lys Gly Ile Asp Arg Gln 
    50                  55                  60                  

Ser Asn Ala Asp Asp Gly Gly Val Ile Lys Lys Glu Leu Leu Glu Ser 
65                  70                  75                  80  

Asp Ile Ile Ile Ile Ser Ser Pro Val Tyr Leu Gln Asn Val Ser Val 
                85                  90                  95      

Asp Thr Lys Asn Phe Ile Glu Arg Ile Gly Gly Trp Ser His Leu Phe 
            100                 105                 110         

Arg Leu Ala Gly Lys Phe Val Val Thr Leu Asp Val Ala Glu Ser Asn 
        115                 120                 125             

Gly Ser Asp Asn Val Ser Glu Tyr Leu Arg Asp Ile Phe Ser Tyr Met 
    130                 135                 140                 

Gly Gly Gln Ile Leu His Gln Val Ser Ile Thr Asn Ser Leu Lys Asp 
145                 150                 155                 160 

Ile Ala Glu Ala Gln Leu Met Glu Ala Thr Tyr Lys Ile Glu Asp Val 
                165                 170                 175     

Leu Glu Gly Lys Ile Lys Tyr Lys Thr Thr Asp Tyr Gln Glu Arg Ala 
            180                 185                 190         

Tyr Gln Thr Leu Lys Leu Ile Leu Glu Asn Tyr Asp Ser Glu His Phe 
        195                 200                 205             

Glu Lys Met Tyr Trp Glu Lys Lys Arg Leu Phe Glu Ala Asn Ser Leu 
    210                 215                 220                 

Glu Glu Trp Tyr Tyr Val Glu Asn Ile Lys 
225                 230                 

<210>   4067
<211>   927
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4067
atgttgaaaa tattaaataa ctctgtcata tatttatgtt tgattccgtt attgttccta   60
ttattgataa tttttccaaa tgattcatta atctattatt ttcgattgat tttaatttcg   120
ttaatatcaa ttacattaca tgaactaggt cattttttag tgggaagatg tttatcttat   180
aaactagaga tgcttgctac tccctttttc ttctatttca gaaaaaaaat atatttcaaa   240
tttccagtgt tattagcatt cggttattgt caaatgagta atagaaacat tactaatgaa   300
aaaaatagtg ataggaattt ggtgttctac ttctttgggg gaggtggagc taacctaatt   360
gtcgcaatat tagcactttt gggatttgtg ccgtacgcat cagaattttt tattttgaat   420
ataattcttt ttctagttac ggtatgttta ccaattgatg gaacagatgg caatgctatt   480
agagagatag ttttgtattc aaaagattca aaaacatatc agagattctt tgcgaacagt   540
ctctataata atccttatat aacaatcgac gattttgcaa aattaacctc taaagaaaaa   600
tctttttttt caaaatttga aaaatgtttg ataaaccttt actttgaagt gaaaggtgaa   660
gggtcagcat ttacaattgc taatcatgaa gtttttgatt caaatattca ggaaaatatt   720
atccatgagt actataaatt actacataaa tcttctgatt ggattattcc acagaactta   780
tctttagaag aagttgtttt taccttgtca aactatattt actcgaaaaa taataaatat   840
ttagaaaaga ttaagtatct aaagaaatta gtagatttta gacaagaaga aattatcgac   900
tttattttga acaaggagga agtattg                                       927

<210>   4068
<211>   309
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903811 (e-178)

<400>   4068
Met Leu Lys Ile Leu Asn Asn Ser Val Ile Tyr Leu Cys Leu Ile Pro 
1               5                   10                  15      

Leu Leu Phe Leu Leu Leu Ile Ile Phe Pro Asn Asp Ser Leu Ile Tyr 
            20                  25                  30          

Tyr Phe Arg Leu Ile Leu Ile Ser Leu Ile Ser Ile Thr Leu His Glu 
        35                  40                  45              

Leu Gly His Phe Leu Val Gly Arg Cys Leu Ser Tyr Lys Leu Glu Met 
    50                  55                  60                  

Leu Ala Thr Pro Phe Phe Phe Tyr Phe Arg Lys Lys Ile Tyr Phe Lys 
65                  70                  75                  80  

Phe Pro Val Leu Leu Ala Phe Gly Tyr Cys Gln Met Ser Asn Arg Asn 
                85                  90                  95      

Ile Thr Asn Glu Lys Asn Ser Asp Arg Asn Leu Val Phe Tyr Phe Phe 
            100                 105                 110         

Gly Gly Gly Gly Ala Asn Leu Ile Val Ala Ile Leu Ala Leu Leu Gly 
        115                 120                 125             

Phe Val Pro Tyr Ala Ser Glu Phe Phe Ile Leu Asn Ile Ile Leu Phe 
    130                 135                 140                 

Leu Val Thr Val Cys Leu Pro Ile Asp Gly Thr Asp Gly Asn Ala Ile 
145                 150                 155                 160 

Arg Glu Ile Val Leu Tyr Ser Lys Asp Ser Lys Thr Tyr Gln Arg Phe 
                165                 170                 175     

Phe Ala Asn Ser Leu Tyr Asn Asn Pro Tyr Ile Thr Ile Asp Asp Phe 
            180                 185                 190         

Ala Lys Leu Thr Ser Lys Glu Lys Ser Phe Phe Ser Lys Phe Glu Lys 
        195                 200                 205             

Cys Leu Ile Asn Leu Tyr Phe Glu Val Lys Gly Glu Gly Ser Ala Phe 
    210                 215                 220                 

Thr Ile Ala Asn His Glu Val Phe Asp Ser Asn Ile Gln Glu Asn Ile 
225                 230                 235                 240 

Ile His Glu Tyr Tyr Lys Leu Leu His Lys Ser Ser Asp Trp Ile Ile 
                245                 250                 255     

Pro Gln Asn Leu Ser Leu Glu Glu Val Val Phe Thr Leu Ser Asn Tyr 
            260                 265                 270         

Ile Tyr Ser Lys Asn Asn Lys Tyr Leu Glu Lys Ile Lys Tyr Leu Lys 
        275                 280                 285             

Lys Leu Val Asp Phe Arg Gln Glu Glu Ile Ile Asp Phe Ile Leu Asn 
    290                 295                 300                 

Lys Glu Glu Val Leu 
305                 

<210>   4069
<211>   2106
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4069
gtgaaaattc caatgatata tcaaatggaa aattcagaat gtggattagc atgctgtgcc   60
atgatattga actattttaa atatgagatt tctttaaatg aactacgtga aatctaccca   120
tcatccagat ctggatattc tctcctatct ataagtaaag ttttaggaga ttttaatata   180
agttctcatg cttttaaagc ttcggtaaga gatttaaaac cgctcagttt cccactcatt   240
tgcttctggg agagttctca ttttattatt cttgaaaaaa ttagtaaaaa caagttttat   300
attttagatc ctgcaaaagg caggcagaga atgtcaataa gtgaatttga aaggcattat   360
tcaaatatca ttttaacatt taaaaagtta gatagcttta tgtctcgtaa agataataag   420
aagtcgcctg ttttaaagta tttttttaag tataggaata agctagggat tttatttttt   480
gtaacagcat tattgtatgt aatacaatca ttagtaccta tagctaatag atacataatt   540
gacacgaatt tcaaggacga ttcgtattcg tctagaatgt tatttactat attatttata   600
tttactgttt cattctcact aatgtattta ttaagacaga tatatgttgc atccttaaaa   660
tatataatgg ataaagagat tagctatgat tttatgaaac atttgatata tttaccttac   720
agtttttatg aaaaacgtac tttaggggat atacttttta gagctaactc tattgtttat   780
ataagagaaa tactatcaaa taattttata gcagctatac ttgatttgtt aatgattgtg   840
gtttatgctg tggttttatt tagcttttct aagtacatgg taatcttttt aatatcacta   900
agtctagctc tatctattgt aatgtatcca atcataaaaa tctcaaaaaa tttaattgat   960
aaaaatataa aagaaaaggt taatgttcaa aatattactt ccgaagtaat ttctaaaaat   1020
agtgatatta agctaactgg agaagaggaa ttttggatta acaaatggga taattttaat   1080
acaaaacagc tcatcatagg tcgaaaactt gatatacatt tatcaattgt tagtagtata   1140
acgaatgttt tacaaattat tctccctgtt ttgaccctta ttgtaggtgt aaatataaaa   1200
acattcgaac aattgacgtt aggacaaatt gtagcaataa gtacagtctc accatacttt   1260
atttctccta taatttcttt aagtgataac tatatacaat taatgttatt aaagggatat   1320
tttttaagaa tagaggatgt gtttaatact aaatccgaat taattccaga aagagtcagt   1380
caagatataa aatttgataa aaaaatagaa ttaaaagata tttggtataa atatggatta   1440
tttgatgatt atgttttgaa aggaataaat gttactatta aaaaaggaga aactgttgct   1500
attgttggag aatcaggttc aggtaagagt acattagcta aaattttatt aggtttatta   1560
gaacctaata ttggttcaat agaagttgat ggagtagaaa aagaagaaat tggtcaaaca   1620
ttgtatagaa agatttttgg agcagtgtta caaaattcaa ccctaagtta tggtacctta   1680
agagagaatt tgacatttgg acactttgtt tcagatgaag aattaatgac aaatctaaat   1740
tcaattggtc ttagcaatgt agttaaatct ttacctcttg gattagagac aatcatcgct   1800
gaagaaggta ataacttttc tggagggcag cagcaaatga tacttttagc tcgttgtctt   1860
ttgtcgaaac cttcggtagt tgttttggac gaagcaacaa gtagtttaga taatttatct   1920
caacaaatta caacttctta cttaagtgaa atcggtacca ctaagatttt aattgcccat   1980
cgactagata ctatcaagtc tgcagataag atcttagtaa tgcataatgg tgaaattgta   2040
gagattggga cccatagaga acttcttgaa ctaggaggca tttataagca attgtattca   2100
aataat                                                              2106

<210>   4070
<211>   702
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   toxin secretion ABC transporter, ATP-binding/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903812 (0.E+01)

<400>   4070
Met Lys Ile Pro Met Ile Tyr Gln Met Glu Asn Ser Glu Cys Gly Leu 
1               5                   10                  15      

Ala Cys Cys Ala Met Ile Leu Asn Tyr Phe Lys Tyr Glu Ile Ser Leu 
            20                  25                  30          

Asn Glu Leu Arg Glu Ile Tyr Pro Ser Ser Arg Ser Gly Tyr Ser Leu 
        35                  40                  45              

Leu Ser Ile Ser Lys Val Leu Gly Asp Phe Asn Ile Ser Ser His Ala 
    50                  55                  60                  

Phe Lys Ala Ser Val Arg Asp Leu Lys Pro Leu Ser Phe Pro Leu Ile 
65                  70                  75                  80  

Cys Phe Trp Glu Ser Ser His Phe Ile Ile Leu Glu Lys Ile Ser Lys 
                85                  90                  95      

Asn Lys Phe Tyr Ile Leu Asp Pro Ala Lys Gly Arg Gln Arg Met Ser 
            100                 105                 110         

Ile Ser Glu Phe Glu Arg His Tyr Ser Asn Ile Ile Leu Thr Phe Lys 
        115                 120                 125             

Lys Leu Asp Ser Phe Met Ser Arg Lys Asp Asn Lys Lys Ser Pro Val 
    130                 135                 140                 

Leu Lys Tyr Phe Phe Lys Tyr Arg Asn Lys Leu Gly Ile Leu Phe Phe 
145                 150                 155                 160 

Val Thr Ala Leu Leu Tyr Val Ile Gln Ser Leu Val Pro Ile Ala Asn 
                165                 170                 175     

Arg Tyr Ile Ile Asp Thr Asn Phe Lys Asp Asp Ser Tyr Ser Ser Arg 
            180                 185                 190         

Met Leu Phe Thr Ile Leu Phe Ile Phe Thr Val Ser Phe Ser Leu Met 
        195                 200                 205             

Tyr Leu Leu Arg Gln Ile Tyr Val Ala Ser Leu Lys Tyr Ile Met Asp 
    210                 215                 220                 

Lys Glu Ile Ser Tyr Asp Phe Met Lys His Leu Ile Tyr Leu Pro Tyr 
225                 230                 235                 240 

Ser Phe Tyr Glu Lys Arg Thr Leu Gly Asp Ile Leu Phe Arg Ala Asn 
                245                 250                 255     

Ser Ile Val Tyr Ile Arg Glu Ile Leu Ser Asn Asn Phe Ile Ala Ala 
            260                 265                 270         

Ile Leu Asp Leu Leu Met Ile Val Val Tyr Ala Val Val Leu Phe Ser 
        275                 280                 285             

Phe Ser Lys Tyr Met Val Ile Phe Leu Ile Ser Leu Ser Leu Ala Leu 
    290                 295                 300                 

Ser Ile Val Met Tyr Pro Ile Ile Lys Ile Ser Lys Asn Leu Ile Asp 
305                 310                 315                 320 

Lys Asn Ile Lys Glu Lys Val Asn Val Gln Asn Ile Thr Ser Glu Val 
                325                 330                 335     

Ile Ser Lys Asn Ser Asp Ile Lys Leu Thr Gly Glu Glu Glu Phe Trp 
            340                 345                 350         

Ile Asn Lys Trp Asp Asn Phe Asn Thr Lys Gln Leu Ile Ile Gly Arg 
        355                 360                 365             

Lys Leu Asp Ile His Leu Ser Ile Val Ser Ser Ile Thr Asn Val Leu 
    370                 375                 380                 

Gln Ile Ile Leu Pro Val Leu Thr Leu Ile Val Gly Val Asn Ile Lys 
385                 390                 395                 400 

Thr Phe Glu Gln Leu Thr Leu Gly Gln Ile Val Ala Ile Ser Thr Val 
                405                 410                 415     

Ser Pro Tyr Phe Ile Ser Pro Ile Ile Ser Leu Ser Asp Asn Tyr Ile 
            420                 425                 430         

Gln Leu Met Leu Leu Lys Gly Tyr Phe Leu Arg Ile Glu Asp Val Phe 
        435                 440                 445             

Asn Thr Lys Ser Glu Leu Ile Pro Glu Arg Val Ser Gln Asp Ile Lys 
    450                 455                 460                 

Phe Asp Lys Lys Ile Glu Leu Lys Asp Ile Trp Tyr Lys Tyr Gly Leu 
465                 470                 475                 480 

Phe Asp Asp Tyr Val Leu Lys Gly Ile Asn Val Thr Ile Lys Lys Gly 
                485                 490                 495     

Glu Thr Val Ala Ile Val Gly Glu Ser Gly Ser Gly Lys Ser Thr Leu 
            500                 505                 510         

Ala Lys Ile Leu Leu Gly Leu Leu Glu Pro Asn Ile Gly Ser Ile Glu 
        515                 520                 525             

Val Asp Gly Val Glu Lys Glu Glu Ile Gly Gln Thr Leu Tyr Arg Lys 
    530                 535                 540                 

Ile Phe Gly Ala Val Leu Gln Asn Ser Thr Leu Ser Tyr Gly Thr Leu 
545                 550                 555                 560 

Arg Glu Asn Leu Thr Phe Gly His Phe Val Ser Asp Glu Glu Leu Met 
                565                 570                 575     

Thr Asn Leu Asn Ser Ile Gly Leu Ser Asn Val Val Lys Ser Leu Pro 
            580                 585                 590         

Leu Gly Leu Glu Thr Ile Ile Ala Glu Glu Gly Asn Asn Phe Ser Gly 
        595                 600                 605             

Gly Gln Gln Gln Met Ile Leu Leu Ala Arg Cys Leu Leu Ser Lys Pro 
    610                 615                 620                 

Ser Val Val Val Leu Asp Glu Ala Thr Ser Ser Leu Asp Asn Leu Ser 
625                 630                 635                 640 

Gln Gln Ile Thr Thr Ser Tyr Leu Ser Glu Ile Gly Thr Thr Lys Ile 
                645                 650                 655     

Leu Ile Ala His Arg Leu Asp Thr Ile Lys Ser Ala Asp Lys Ile Leu 
            660                 665                 670         

Val Met His Asn Gly Glu Ile Val Glu Ile Gly Thr His Arg Glu Leu 
        675                 680                 685             

Leu Glu Leu Gly Gly Ile Tyr Lys Gln Leu Tyr Ser Asn Asn 
    690                 695                 700         

<210>   4071
<211>   1401
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4071
atgaaaaaaa aatattggac tttagcgata ttattctttt gtttgttcaa taattctgtt   60
actgctcaag aaatacctaa aaatcttgat ggcaatataa ctcacactca gactagcgaa   120
agtttttctg aatctgatga aaaacaggtt gactattcta ataaaaatca agaagaagta   180
gaccaaaata aatttcgtat tcaaatcgat aagacagaat tatttgtaac aacagataaa   240
catttagaaa aaaactgttg taaattggaa cttgaaccac aaataaataa cgatattgtt   300
aactctgaaa gtaataattt actaggcgaa gataatttag ataataaaat taaggaaaat   360
gtttctcatc tagataatag aggaggaaat atagagcatg acaaagataa cttagaatcg   420
tcgattgtaa gaaaatatga atgggatata gataaagtta ctggtggagg cgaaagttat   480
aaattatatt ctaaaagtaa ttctaaagtt tcaattgcta ttttagattc aggagtcgat   540
ttacaaaata ctggattact gaaaaatctt tcaaatcact caaaaaacta tgtccccaat   600
aaaggatatt taggaaaaga ggagggagag gaaggaataa tatcagatat tcaagataga   660
ttaggtcatg gtacggctgt tgtagctcaa attgtagggg atgacaatat taatggagta   720
aatcctcacg ttaatattaa cgtctataga atatttggta agtcgtcagc tagtccagat   780
tggattgtaa aagcaatttt tgatgctgta gatgatggca atgatattat caatcttagt   840
actggacaat atttaatgat tgatggagaa tatgaggacg gaacaaatga ttttgaaaca   900
tttttgaagt ataaaaaggc tattgattac gcgaatcaaa aaggagtaat tatagtagct   960
gcattaggga atgactccct aaatgtatca aatcagtcag atttattgaa acttattagt   1020
tcacgcaaaa aagtaagaaa accaggatta gtagttgatg ttccaagtta tttctcatct   1080
acaatttcgg tcggaggcat agatcgctta ggtaatttat cagattttag caataaaggg   1140
gattctgatg caatatatgc gcctgcaggc tcaacattat ctctttcaga attaggactt   1200
aataacttta ttaatgcaga aaaatataaa gaagattgga ttttttcggc aacactagga   1260
ggatatacgt atctttatgg aaactcattt gctgctccta aagtttctgg tgcgattgca   1320
atgattattg ataaatacaa attaaaagat cagccctata attatatgtt tgtaaaaaaa   1380
ttctggaaga aacattacca g                                             1401

<210>   4072
<211>   467
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   serine protease, subtilase family, FRAMESHIFT
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903813 (0.E+01)

<400>   4072
Met Lys Lys Lys Tyr Trp Thr Leu Ala Ile Leu Phe Phe Cys Leu Phe 
1               5                   10                  15      

Asn Asn Ser Val Thr Ala Gln Glu Ile Pro Lys Asn Leu Asp Gly Asn 
            20                  25                  30          

Ile Thr His Thr Gln Thr Ser Glu Ser Phe Ser Glu Ser Asp Glu Lys 
        35                  40                  45              

Gln Val Asp Tyr Ser Asn Lys Asn Gln Glu Glu Val Asp Gln Asn Lys 
    50                  55                  60                  

Phe Arg Ile Gln Ile Asp Lys Thr Glu Leu Phe Val Thr Thr Asp Lys 
65                  70                  75                  80  

His Leu Glu Lys Asn Cys Cys Lys Leu Glu Leu Glu Pro Gln Ile Asn 
                85                  90                  95      

Asn Asp Ile Val Asn Ser Glu Ser Asn Asn Leu Leu Gly Glu Asp Asn 
            100                 105                 110         

Leu Asp Asn Lys Ile Lys Glu Asn Val Ser His Leu Asp Asn Arg Gly 
        115                 120                 125             

Gly Asn Ile Glu His Asp Lys Asp Asn Leu Glu Ser Ser Ile Val Arg 
    130                 135                 140                 

Lys Tyr Glu Trp Asp Ile Asp Lys Val Thr Gly Gly Gly Glu Ser Tyr 
145                 150                 155                 160 

Lys Leu Tyr Ser Lys Ser Asn Ser Lys Val Ser Ile Ala Ile Leu Asp 
                165                 170                 175     

Ser Gly Val Asp Leu Gln Asn Thr Gly Leu Leu Lys Asn Leu Ser Asn 
            180                 185                 190         

His Ser Lys Asn Tyr Val Pro Asn Lys Gly Tyr Leu Gly Lys Glu Glu 
        195                 200                 205             

Gly Glu Glu Gly Ile Ile Ser Asp Ile Gln Asp Arg Leu Gly His Gly 
    210                 215                 220                 

Thr Ala Val Val Ala Gln Ile Val Gly Asp Asp Asn Ile Asn Gly Val 
225                 230                 235                 240 

Asn Pro His Val Asn Ile Asn Val Tyr Arg Ile Phe Gly Lys Ser Ser 
                245                 250                 255     

Ala Ser Pro Asp Trp Ile Val Lys Ala Ile Phe Asp Ala Val Asp Asp 
            260                 265                 270         

Gly Asn Asp Ile Ile Asn Leu Ser Thr Gly Gln Tyr Leu Met Ile Asp 
        275                 280                 285             

Gly Glu Tyr Glu Asp Gly Thr Asn Asp Phe Glu Thr Phe Leu Lys Tyr 
    290                 295                 300                 

Lys Lys Ala Ile Asp Tyr Ala Asn Gln Lys Gly Val Ile Ile Val Ala 
305                 310                 315                 320 

Ala Leu Gly Asn Asp Ser Leu Asn Val Ser Asn Gln Ser Asp Leu Leu 
                325                 330                 335     

Lys Leu Ile Ser Ser Arg Lys Lys Val Arg Lys Pro Gly Leu Val Val 
            340                 345                 350         

Asp Val Pro Ser Tyr Phe Ser Ser Thr Ile Ser Val Gly Gly Ile Asp 
        355                 360                 365             

Arg Leu Gly Asn Leu Ser Asp Phe Ser Asn Lys Gly Asp Ser Asp Ala 
    370                 375                 380                 

Ile Tyr Ala Pro Ala Gly Ser Thr Leu Ser Leu Ser Glu Leu Gly Leu 
385                 390                 395                 400 

Asn Asn Phe Ile Asn Ala Glu Lys Tyr Lys Glu Asp Trp Ile Phe Ser 
                405                 410                 415     

Ala Thr Leu Gly Gly Tyr Thr Tyr Leu Tyr Gly Asn Ser Phe Ala Ala 
            420                 425                 430         

Pro Lys Val Ser Gly Ala Ile Ala Met Ile Ile Asp Lys Tyr Lys Leu 
        435                 440                 445             

Lys Asp Gln Pro Tyr Asn Tyr Met Phe Val Lys Lys Phe Trp Lys Lys 
    450                 455                 460                 

His Tyr Gln 
465         

<210>   4073
<211>   309
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4073
gtgttaaata taccaaacgt attgagatat gatttgaata tgttacaatt agaatataaa   60
aatgaacaaa gttgggatag tttcatagat aatgttaatt taattgagtt ggaagagaga   120
attcaaacta ctattggaat taaacaaata aacacacaca atattattac tattgcccga   180
gaagggtact ctcaaaatta tttacctaac acttcagaaa atacatataa ttcattacaa   240
gtcagtttag ttggagtatt actacttttt ataagtatgg taaatatttt atgggctaaa   300
aaaagtaaa                                                           309

<210>   4074
<211>   103
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Subtilisin-like serine protease)
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15903813 (9.E-55)

<400>   4074
Met Leu Asn Ile Pro Asn Val Leu Arg Tyr Asp Leu Asn Met Leu Gln 
1               5                   10                  15      

Leu Glu Tyr Lys Asn Glu Gln Ser Trp Asp Ser Phe Ile Asp Asn Val 
            20                  25                  30          

Asn Leu Ile Glu Leu Glu Glu Arg Ile Gln Thr Thr Ile Gly Ile Lys 
        35                  40                  45              

Gln Ile Asn Thr His Asn Ile Ile Thr Ile Ala Arg Glu Gly Tyr Ser 
    50                  55                  60                  

Gln Asn Tyr Leu Pro Asn Thr Ser Glu Asn Thr Tyr Asn Ser Leu Gln 
65                  70                  75                  80  

Val Ser Leu Val Gly Val Leu Leu Leu Phe Ile Ser Met Val Asn Ile 
                85                  90                  95      

Leu Trp Ala Lys Lys Ser Lys 
            100             

<210>   4075
<211>   765
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4075
atgagtcaaa agatgaatca ccttgatgta ggggagtttg tcttattgct gcctgaacac   60
ctccgttcag aggaagaaca ttataaatct gtttttgaag acgacttaac cagtcgcata   120
tctagtcaag atgaacgaca gcaaatgact gctacggtag gttatttaga atcaggtcag   180
gatcgttttg tgtataatac gacccctatt tcttaccagc agtttttgaa agatccaatc   240
atcattgtta taacacccca atcaactggt ccacagtcca ttttgttttg gatagacgca   300
gtacagaact acgttctctt taatcaattg tctgatgccc aggagcttat ccagagacaa   360
ggcattgaaa attgggtctc agaaatgcaa acaggttacc acaactacat cacattattg   420
gataatatcc agagggaacg ttgggtaatg ctagcaggag ctgtgcttgg gattgcaact   480
tcaatcttgt tgtttaacac tatgaatagg ctctactttg aagaatttag acgtgccatt   540
tttatcaaac gcattgcagg tctcaggttc ttagaaatcc atcgcactta tctctttgct   600
caactgggtg tgtttttact gggatttgtt gcgagtgtat ttcttcaggt agagatagga   660
gttgctttct tagtcttgtt actctttact ggtctatctc ttttacagtt acatgtccaa   720
atgcagaaag aaaacaagat gtccatgctt gttttgaagg gaggt                   765

<210>   4076
<211>   255
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903814 (e-143)

<400>   4076
Met Ser Gln Lys Met Asn His Leu Asp Val Gly Glu Phe Val Leu Leu 
1               5                   10                  15      

Leu Pro Glu His Leu Arg Ser Glu Glu Glu His Tyr Lys Ser Val Phe 
            20                  25                  30          

Glu Asp Asp Leu Thr Ser Arg Ile Ser Ser Gln Asp Glu Arg Gln Gln 
        35                  40                  45              

Met Thr Ala Thr Val Gly Tyr Leu Glu Ser Gly Gln Asp Arg Phe Val 
    50                  55                  60                  

Tyr Asn Thr Thr Pro Ile Ser Tyr Gln Gln Phe Leu Lys Asp Pro Ile 
65                  70                  75                  80  

Ile Ile Val Ile Thr Pro Gln Ser Thr Gly Pro Gln Ser Ile Leu Phe 
                85                  90                  95      

Trp Ile Asp Ala Val Gln Asn Tyr Val Leu Phe Asn Gln Leu Ser Asp 
            100                 105                 110         

Ala Gln Glu Leu Ile Gln Arg Gln Gly Ile Glu Asn Trp Val Ser Glu 
        115                 120                 125             

Met Gln Thr Gly Tyr His Asn Tyr Ile Thr Leu Leu Asp Asn Ile Gln 
    130                 135                 140                 


Arg Glu Arg Trp Val Met Leu Ala Gly Ala Val Leu Gly Ile Ala Thr 
145                 150                 155                 160 

Ser Ile Leu Leu Phe Asn Thr Met Asn Arg Leu Tyr Phe Glu Glu Phe 
                165                 170                 175     

Arg Arg Ala Ile Phe Ile Lys Arg Ile Ala Gly Leu Arg Phe Leu Glu 
            180                 185                 190         

Ile His Arg Thr Tyr Leu Phe Ala Gln Leu Gly Val Phe Leu Leu Gly 
        195                 200                 205             

Phe Val Ala Ser Val Phe Leu Gln Val Glu Ile Gly Val Ala Phe Leu 
    210                 215                 220                 

Val Leu Leu Leu Phe Thr Gly Leu Ser Leu Leu Gln Leu His Val Gln 
225                 230                 235                 240 

Met Gln Lys Glu Asn Lys Met Ser Met Leu Val Leu Lys Gly Gly 
                245                 250                 255 

<210>   4077
<211>   630
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4077
atgattgaac ttaaacaggt gagtaaatct tttggagaac gagagttatt ttcgaatctt   60
tcaatgacat ttgaggctgg aaaagtctat gccttaattg gttcaagtgg tagcggaaaa   120
acaaccttga tgaacatgat tgggaaatta gaaccttatg atgggacgat tttttaccga   180
ggtaaagact tggccaatta taaatcaagt gattttttcc gtcacgaatt gggctacctc   240
ttccagaact ttggcttaat tgaaaaccaa agtattgaag aaaaccttaa gctaggtctc   300
attggtcaaa agttgagtcg gtcggaacag cggttgaggc agaagcaggc tttagaacag   360
gtcggcctgg tttatcttga cctagataag cgcatctttg agttatcggg cggagaatcg   420
caacgggttg ccttggcaaa aattatctta aagaatccac cctttattct ggcagatgag   480
ccaacagctt caatagaccc agcaacctct cagttgatta tggagatttt gctatctctt   540
cgagatgata ataggctaat cattatcgca acacataatc cggcaatttg ggagatggct   600
gatgaagtgt tcacgatgga tcatctgaaa                                    630

<210>   4078
<211>   210
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903815 (e-116)

<400>   4078
Met Ile Glu Leu Lys Gln Val Ser Lys Ser Phe Gly Glu Arg Glu Leu 
1               5                   10                  15      

Phe Ser Asn Leu Ser Met Thr Phe Glu Ala Gly Lys Val Tyr Ala Leu 
            20                  25                  30          

Ile Gly Ser Ser Gly Ser Gly Lys Thr Thr Leu Met Asn Met Ile Gly 
        35                  40                  45              

Lys Leu Glu Pro Tyr Asp Gly Thr Ile Phe Tyr Arg Gly Lys Asp Leu 
    50                  55                  60                  

Ala Asn Tyr Lys Ser Ser Asp Phe Phe Arg His Glu Leu Gly Tyr Leu 
65                  70                  75                  80  

Phe Gln Asn Phe Gly Leu Ile Glu Asn Gln Ser Ile Glu Glu Asn Leu 
                85                  90                  95      

Lys Leu Gly Leu Ile Gly Gln Lys Leu Ser Arg Ser Glu Gln Arg Leu 
            100                 105                 110         

Arg Gln Lys Gln Ala Leu Glu Gln Val Gly Leu Val Tyr Leu Asp Leu 
        115                 120                 125             

Asp Lys Arg Ile Phe Glu Leu Ser Gly Gly Glu Ser Gln Arg Val Ala 
    130                 135                 140                 

Leu Ala Lys Ile Ile Leu Lys Asn Pro Pro Phe Ile Leu Ala Asp Glu 
145                 150                 155                 160 

Pro Thr Ala Ser Ile Asp Pro Ala Thr Ser Gln Leu Ile Met Glu Ile 
                165                 170                 175     

Leu Leu Ser Leu Arg Asp Asp Asn Arg Leu Ile Ile Ile Ala Thr His 
            180                 185                 190         

Asn Pro Ala Ile Trp Glu Met Ala Asp Glu Val Phe Thr Met Asp His 
        195                 200                 205             

Leu Lys 
    210 

<210>   4079
<211>   159
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4079
atgaaaaaat tcgacaatta tattattgag aagccttgcg attctaattc agataaactg   60
caaaaaatct taataattga aagtttggta gatgatattt tgcaattttc tctcagaatc   120
aataatagtg taggagagat tttcctccta caaccgttt                          159

<210>   4080
<211>   53
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903816 (6.E-26)

<400>   4080
Met Lys Lys Phe Asp Asn Tyr Ile Ile Glu Lys Pro Cys Asp Ser Asn 
1               5                   10                  15      

Ser Asp Lys Leu Gln Lys Ile Leu Ile Ile Glu Ser Leu Val Asp Asp 
            20                  25                  30          

Ile Leu Gln Phe Ser Leu Arg Ile Asn Asn Ser Val Gly Glu Ile Phe 
        35                  40                  45              

Leu Leu Gln Pro Phe 
    50              

<210>   4081
<211>   411
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4081
atggaacaaa cattctttat catcaaacca gatggtgtaa aaagagggct agtgggtgaa   60
gtgttaaagc gcatcgaaca acgtggattt acaatcgaaa aattggagtt tcgttcacag   120
gtttcagaag agttgattga ccagcactat caggacttgg ttggtcagag tttttaccca   180
ccgattcgtg aattcatgac ttcaggtcca gttcttgtgg gtgtcatttc tggtcccaaa   240
gtaatcgaaa cttggcggac catgatgggt gcaactcgtc cagaagaagc tttaccaggc   300
actattcgag gtgattttgc aaaagctgct ggagaaaatg agattatcca aaatgttgta   360
catggttcag attcagaaga gtcagctaag cgagaaattg ctctttggtt t            411

<210>   4082
<211>   137
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   nucleoside diphosphate kinase (ndk)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903817 (6.E-76)

<400>   4082
Met Glu Gln Thr Phe Phe Ile Ile Lys Pro Asp Gly Val Lys Arg Gly 
1               5                   10                  15      

Leu Val Gly Glu Val Leu Lys Arg Ile Glu Gln Arg Gly Phe Thr Ile 
            20                  25                  30          

Glu Lys Leu Glu Phe Arg Ser Gln Val Ser Glu Glu Leu Ile Asp Gln 
        35                  40                  45              

His Tyr Gln Asp Leu Val Gly Gln Ser Phe Tyr Pro Pro Ile Arg Glu 
    50                  55                  60                  

Phe Met Thr Ser Gly Pro Val Leu Val Gly Val Ile Ser Gly Pro Lys 
65                  70                  75                  80  

Val Ile Glu Thr Trp Arg Thr Met Met Gly Ala Thr Arg Pro Glu Glu 
                85                  90                  95      

Ala Leu Pro Gly Thr Ile Arg Gly Asp Phe Ala Lys Ala Ala Gly Glu 
            100                 105                 110         

Asn Glu Ile Ile Gln Asn Val Val His Gly Ser Asp Ser Glu Glu Ser 
        115                 120                 125             

Ala Lys Arg Glu Ile Ala Leu Trp Phe 
    130                 135         

<210>   4083
<211>   3675
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4083
gtggttgatg taaatcgttt taaaagtatg caaatcaccc tagcttctcc aagtaaagtc   60
cgttcatggt cttatggaga agtcaaaaaa cctgaaacaa tcaattatcg taccttgaaa   120
ccagaacgtg aaggactctt tgatgaagtg atctttggtc ctacaaaaga ctgggaatgt   180
gcttgtggta agtacaaacg cattcgttac agaggaattg tttgtgaccg ctgtggggtt   240
gaagtaacgc gtacgaaagt tcgtcgtgag cgtatgggac atatcgaatt gaaagctcct   300
gtatctcaca tctggtactt caaggggatt ccaagccgta tgggcttgac ccttgatatg   360
agccctcgtg ccctcgagga agttatctac tttgcggctt atgtggtgat tgatcctaag   420
gatacaccac ttgagcacaa gtctatcatg acagagcgcg aataccgaga gcgcttgcgt   480
gaatatggtt atggttcatt tgttgccaag atgggtgcgg aagccatcca agaccttttg   540
aagcaagtag atcttgaaaa agaaattgct gaactcaaag aagaattgaa aacagctact   600
ggacaaaagc gtgtcaaagc catccgtcgt ttggatgttt tggatgcctt ttacaagtct   660
ggaaacaaac ctgaatggat gattcttaac atccttccgg ttatcccacc agatcttcgt   720
ccaatgttgc agttggatgg tggccgtttt gcctcatctg acttgaatga cctttaccgc   780
cgtgttatca accgtaacaa ccgtttggct cgtttgcttg agttaaatgc accaggtatc   840
atcgttcaaa atgagaagcg tatgcttcaa gaagcagttg acgctttgat tgacaatggt   900
cgtcgtggtc gtccaatcac aggaccaggt agccgtccat tgaaatcatt gagccacatg   960
cttaaaggta aacaaggacg cttccgtcaa aacttgctcg gtaaacgtgt tgacttctca   1020
ggacgttcag ttatcgccgt tggtccaact cttaagatgt accaatgtgg tgtgccgcgt   1080
gaaatggcga ttgaactctt taaaccattt gtcatgcgtg aaatcgttgc ccgtgatatc   1140
gtgcaaaacg tcaaagcagc taaacgcttg gtggaacgcg gagatgagcg tatctgggat   1200
atccttgaag aagtgattaa agaacaccca gtgcttttga accgcgcacc gacccttcac   1260
cgtttgggta tccaagcctt cgagccagtc ttgattgatg gtaaggctct tcgcttgcac   1320
ccacttgtct gtgaagccta caatgctgac tttgacgggg accaaatggc catccacgta   1380
ccactttcag aagaagcaca agcagaagct cgtatcctca tgctagctgc tgagcacatc   1440
ttgaacccga aagatgggaa accggtagtt actccatctc aggacatggt tttgggtaac   1500
tactacttga ccatggaaga agctggtcgc gaaggtgaag gaatggtctt caaagaccgt   1560
gacgaagcgg ttatggctta ccgcaatggt tatgttcacc tccactcacg tgttggtatc   1620
gcaacagaca gcctcaacaa gccttggaca gaagagcaaa gacataaggt cttgcttaca   1680
acagttggta aaattctctt caacgatatc atgccagagg ggctaccata cttgcaagaa   1740
ccaaacaatg ccaacttgac agaaggtgtt ccagctaaat acttcttgcc acttggtgga   1800
gatatcaagg aagctatcag caatcttgag ctcaaccctc cattcaagaa gaaaaacctt   1860
ggaaatatca tcgctgaaat cttcaaacgt ttccgtacga cagaaacttc tgccctactt   1920
gaccgcatga agaacctcgg ttaccaccac tcaactcttg caggattgac agtgggtatt   1980
gccgatatcc cagtcgttga tgacaaggct gaaatcattg aagaatcaca caaacgtgtc   2040
gaacaaatca ccaaacaatt ccgtcgtggt atgatcacag acgacgagcg ttacaatgct   2100
gttacagctg aatggcgtgc tgcccgtgaa aaacttgaga aacgcttgat tgctaaccaa   2160
gatcctaaga acccaatcgt tatgatgatg gactctggag cccgtggtaa catctcaaac   2220
ttctcacagc ttgccggtat gcgtggtctg atggctgctc cgaatggacg tatcatggaa   2280
ttgccaatcc tttcaaactt ccgcgaaggt ttgtcggtat tggaaatgtt cttctcaact   2340
cacggtgctc gtaaaggtat gaccgatacg gcccttaaga cagccgactc aggttacttg   2400
actcgtcgtt tggtcgacgt tgcccaagac gttatcatcc gtgaggacga ctgtggaact   2460
gaccgtggtc tcttgatccg ttctatcgca gaaggaaaag agatgatcga gtctctcgaa   2520
gagcgtctca acggtcgtta cactaagaaa actgttaaac atccagaaac tggtgcagtg   2580
attattggtc caaatgaatt gattacagaa gacaaggcgc gtgaaattgt caatgctggt   2640
gtggaagaag tgactatccg ttctgtattt acatgtaaca ctcgtcacgg tgtctgccgt   2700
cactgttacg gtatcaactt ggcgactggt gatgcggttg aagttggtga agcagttggt   2760
acaatcgctg cccaatctat cggggaacct ggtacacagc ttacaatgcg taccttccac   2820
acaggtgggg ttgcctcaaa taccgatatc actcagggtc ttcctcgtgt ccaagaaatc   2880
tttgaagccc gcaatcctaa aggggaagcg gttattacag aggttaaagg acaagttact   2940
gctatcgaag aagatgcatc aactcgtacc aagaaagtct ttgttaaggg tgaaactggc   3000
gaaggtgaat atgtcgttcc atttacagct cgtatgcgtg tcgaagttgg gggccaagta   3060
gcgcgtggtg ctgctctgac agaaggttct atccaaccaa aacgtctcct tgcagttcgt   3120
gatgtcttgt cagttgaaac gtaccttctc ggtgaagtac aaaaagttta ccgtagccaa   3180
ggggtagaaa tcggtgacaa acacatcgag gtaatggttc gtcaaatgat ccgtaaagtc   3240
cgtgtcatgg atccaggtga tacagatctt ctcatgggta ccctcatgga tatcaatgac   3300
tttacagatg ccaacaaaga tgtccttatc gcaggtggag ttccagcgac aggtcgccca   3360
gtccttatgg gaattaccaa agcctcactt gaaacaaaca gtttcttgtc agcggcttcc   3420
ttccaggaaa caactcgtgt ccttactgac gcagctatcc gtggtaagaa agaccatctc   3480
cttggactta aagaaaatgt tatcatcggt aagatcatcc cagctggtac tggtatggcc   3540
cgttaccgta accttgaacc acatgctgtc aacgaagaag aataccttaa tcctccagta   3600
gaggaagaag gaaatgaaga aacaacagaa gtagttgtgg atactgccgt tgaaactgtg   3660
gaagaaacag tagaa                                                    3675

<210>   4084
<211>   1225
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-directed RNA polymerase, beta' subunit (rpoC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903818 (0.E+01)

<400>   4084
Met Val Asp Val Asn Arg Phe Lys Ser Met Gln Ile Thr Leu Ala Ser 
1               5                   10                  15      

Pro Ser Lys Val Arg Ser Trp Ser Tyr Gly Glu Val Lys Lys Pro Glu 
            20                  25                  30          

Thr Ile Asn Tyr Arg Thr Leu Lys Pro Glu Arg Glu Gly Leu Phe Asp 
        35                  40                  45              

Glu Val Ile Phe Gly Pro Thr Lys Asp Trp Glu Cys Ala Cys Gly Lys 
    50                  55                  60                  

Tyr Lys Arg Ile Arg Tyr Arg Gly Ile Val Cys Asp Arg Cys Gly Val 
65                  70                  75                  80  

Glu Val Thr Arg Thr Lys Val Arg Arg Glu Arg Met Gly His Ile Glu 
                85                  90                  95      

Leu Lys Ala Pro Val Ser His Ile Trp Tyr Phe Lys Gly Ile Pro Ser 
            100                 105                 110         

Arg Met Gly Leu Thr Leu Asp Met Ser Pro Arg Ala Leu Glu Glu Val 
        115                 120                 125             

Ile Tyr Phe Ala Ala Tyr Val Val Ile Asp Pro Lys Asp Thr Pro Leu 
    130                 135                 140                 


Glu His Lys Ser Ile Met Thr Glu Arg Glu Tyr Arg Glu Arg Leu Arg 
145                 150                 155                 160 

Glu Tyr Gly Tyr Gly Ser Phe Val Ala Lys Met Gly Ala Glu Ala Ile 
                165                 170                 175     

Gln Asp Leu Leu Lys Gln Val Asp Leu Glu Lys Glu Ile Ala Glu Leu 
            180                 185                 190         

Lys Glu Glu Leu Lys Thr Ala Thr Gly Gln Lys Arg Val Lys Ala Ile 
        195                 200                 205             

Arg Arg Leu Asp Val Leu Asp Ala Phe Tyr Lys Ser Gly Asn Lys Pro 
    210                 215                 220                 

Glu Trp Met Ile Leu Asn Ile Leu Pro Val Ile Pro Pro Asp Leu Arg 
225                 230                 235                 240 

Pro Met Leu Gln Leu Asp Gly Gly Arg Phe Ala Ser Ser Asp Leu Asn 
                245                 250                 255     

Asp Leu Tyr Arg Arg Val Ile Asn Arg Asn Asn Arg Leu Ala Arg Leu 
            260                 265                 270         

Leu Glu Leu Asn Ala Pro Gly Ile Ile Val Gln Asn Glu Lys Arg Met 
        275                 280                 285             

Leu Gln Glu Ala Val Asp Ala Leu Ile Asp Asn Gly Arg Arg Gly Arg 
    290                 295                 300                 

Pro Ile Thr Gly Pro Gly Ser Arg Pro Leu Lys Ser Leu Ser His Met 
305                 310                 315                 320 

Leu Lys Gly Lys Gln Gly Arg Phe Arg Gln Asn Leu Leu Gly Lys Arg 
                325                 330                 335     

Val Asp Phe Ser Gly Arg Ser Val Ile Ala Val Gly Pro Thr Leu Lys 
            340                 345                 350         

Met Tyr Gln Cys Gly Val Pro Arg Glu Met Ala Ile Glu Leu Phe Lys 
        355                 360                 365             

Pro Phe Val Met Arg Glu Ile Val Ala Arg Asp Ile Val Gln Asn Val 
    370                 375                 380                 

Lys Ala Ala Lys Arg Leu Val Glu Arg Gly Asp Glu Arg Ile Trp Asp 
385                 390                 395                 400 

Ile Leu Glu Glu Val Ile Lys Glu His Pro Val Leu Leu Asn Arg Ala 
                405                 410                 415     

Pro Thr Leu His Arg Leu Gly Ile Gln Ala Phe Glu Pro Val Leu Ile 
            420                 425                 430         

Asp Gly Lys Ala Leu Arg Leu His Pro Leu Val Cys Glu Ala Tyr Asn 
        435                 440                 445             

Ala Asp Phe Asp Gly Asp Gln Met Ala Ile His Val Pro Leu Ser Glu 
    450                 455                 460                 

Glu Ala Gln Ala Glu Ala Arg Ile Leu Met Leu Ala Ala Glu His Ile 
465                 470                 475                 480 

Leu Asn Pro Lys Asp Gly Lys Pro Val Val Thr Pro Ser Gln Asp Met 
                485                 490                 495     

Val Leu Gly Asn Tyr Tyr Leu Thr Met Glu Glu Ala Gly Arg Glu Gly 
            500                 505                 510         

Glu Gly Met Val Phe Lys Asp Arg Asp Glu Ala Val Met Ala Tyr Arg 
        515                 520                 525             

Asn Gly Tyr Val His Leu His Ser Arg Val Gly Ile Ala Thr Asp Ser 
    530                 535                 540                 

Leu Asn Lys Pro Trp Thr Glu Glu Gln Arg His Lys Val Leu Leu Thr 
545                 550                 555                 560 

Thr Val Gly Lys Ile Leu Phe Asn Asp Ile Met Pro Glu Gly Leu Pro 
                565                 570                 575     

Tyr Leu Gln Glu Pro Asn Asn Ala Asn Leu Thr Glu Gly Val Pro Ala 
            580                 585                 590         

Lys Tyr Phe Leu Pro Leu Gly Gly Asp Ile Lys Glu Ala Ile Ser Asn 
        595                 600                 605             

Leu Glu Leu Asn Pro Pro Phe Lys Lys Lys Asn Leu Gly Asn Ile Ile 
    610                 615                 620                 

Ala Glu Ile Phe Lys Arg Phe Arg Thr Thr Glu Thr Ser Ala Leu Leu 
625                 630                 635                 640 

Asp Arg Met Lys Asn Leu Gly Tyr His His Ser Thr Leu Ala Gly Leu 
                645                 650                 655     

Thr Val Gly Ile Ala Asp Ile Pro Val Val Asp Asp Lys Ala Glu Ile 
            660                 665                 670         

Ile Glu Glu Ser His Lys Arg Val Glu Gln Ile Thr Lys Gln Phe Arg 
        675                 680                 685             

Arg Gly Met Ile Thr Asp Asp Glu Arg Tyr Asn Ala Val Thr Ala Glu 
    690                 695                 700                 

Trp Arg Ala Ala Arg Glu Lys Leu Glu Lys Arg Leu Ile Ala Asn Gln 
705                 710                 715                 720 

Asp Pro Lys Asn Pro Ile Val Met Met Met Asp Ser Gly Ala Arg Gly 
                725                 730                 735     

Asn Ile Ser Asn Phe Ser Gln Leu Ala Gly Met Arg Gly Leu Met Ala 
            740                 745                 750         

Ala Pro Asn Gly Arg Ile Met Glu Leu Pro Ile Leu Ser Asn Phe Arg 
        755                 760                 765             

Glu Gly Leu Ser Val Leu Glu Met Phe Phe Ser Thr His Gly Ala Arg 
    770                 775                 780                 

Lys Gly Met Thr Asp Thr Ala Leu Lys Thr Ala Asp Ser Gly Tyr Leu 
785                 790                 795                 800 

Thr Arg Arg Leu Val Asp Val Ala Gln Asp Val Ile Ile Arg Glu Asp 
                805                 810                 815     

Asp Cys Gly Thr Asp Arg Gly Leu Leu Ile Arg Ser Ile Ala Glu Gly 
            820                 825                 830         

Lys Glu Met Ile Glu Ser Leu Glu Glu Arg Leu Asn Gly Arg Tyr Thr 
        835                 840                 845             

Lys Lys Thr Val Lys His Pro Glu Thr Gly Ala Val Ile Ile Gly Pro 
    850                 855                 860                 

Asn Glu Leu Ile Thr Glu Asp Lys Ala Arg Glu Ile Val Asn Ala Gly 
865                 870                 875                 880 

Val Glu Glu Val Thr Ile Arg Ser Val Phe Thr Cys Asn Thr Arg His 
                885                 890                 895     

Gly Val Cys Arg His Cys Tyr Gly Ile Asn Leu Ala Thr Gly Asp Ala 
            900                 905                 910         

Val Glu Val Gly Glu Ala Val Gly Thr Ile Ala Ala Gln Ser Ile Gly 
        915                 920                 925             

Glu Pro Gly Thr Gln Leu Thr Met Arg Thr Phe His Thr Gly Gly Val 
    930                 935                 940                 

Ala Ser Asn Thr Asp Ile Thr Gln Gly Leu Pro Arg Val Gln Glu Ile 
945                 950                 955                 960 

Phe Glu Ala Arg Asn Pro Lys Gly Glu Ala Val Ile Thr Glu Val Lys 
                965                 970                 975     

Gly Gln Val Thr Ala Ile Glu Glu Asp Ala Ser Thr Arg Thr Lys Lys 
            980                 985                 990         

Val Phe Val Lys Gly Glu Thr Gly Glu Gly Glu Tyr Val Val Pro Phe 

        995                 1000                1005            

Thr Ala Arg Met Arg Val Glu Val Gly Gly Gln Val Ala Arg Gly Ala 
    1010                1015                1020                

Ala Leu Thr Glu Gly Ser Ile Gln Pro Lys Arg Leu Leu Ala Val Arg 
1025                1030                1035                1040

Asp Val Leu Ser Val Glu Thr Tyr Leu Leu Gly Glu Val Gln Lys Val 
                1045                1050                1055    

Tyr Arg Ser Gln Gly Val Glu Ile Gly Asp Lys His Ile Glu Val Met 
            1060                1065                1070        

Val Arg Gln Met Ile Arg Lys Val Arg Val Met Asp Pro Gly Asp Thr 
        1075                1080                1085            

Asp Leu Leu Met Gly Thr Leu Met Asp Ile Asn Asp Phe Thr Asp Ala 
    1090                1095                1100                

Asn Lys Asp Val Leu Ile Ala Gly Gly Val Pro Ala Thr Gly Arg Pro 
1105                1110                1115                1120

Val Leu Met Gly Ile Thr Lys Ala Ser Leu Glu Thr Asn Ser Phe Leu 
                1125                1130                1135    

Ser Ala Ala Ser Phe Gln Glu Thr Thr Arg Val Leu Thr Asp Ala Ala 
            1140                1145                1150        

Ile Arg Gly Lys Lys Asp His Leu Leu Gly Leu Lys Glu Asn Val Ile 
        1155                1160                1165            

Ile Gly Lys Ile Ile Pro Ala Gly Thr Gly Met Ala Arg Tyr Arg Asn 
    1170                1175                1180                

Leu Glu Pro His Ala Val Asn Glu Glu Glu Tyr Leu Asn Pro Pro Val 
1185                1190                1195                1200

Glu Glu Glu Gly Asn Glu Glu Thr Thr Glu Val Val Val Asp Thr Ala 
                1205                1210                1215    

Val Glu Thr Val Glu Glu Thr Val Glu 
            1220                1225

<210>   4085
<211>   3609
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4085
ttggcaggac atgacgttca atacgggaaa catcgtaccc gtcgtagttt ttcaagaatc   60
aaagaagttc ttgacttacc aaatttgatt gaaattcaaa ctgactcatt caaagctttc   120
ctagaccacg gtcttaagga agtgtttgaa gatgtattgc caatttcaaa cttcacagac   180
acaatggagt tggaatttgt tggatatgaa atcaaggaac caaaatatac gctagaagaa   240
gctcgtatcc acgatgctag ctactcagca ccaatttttg taaccttccg tttgatcaat   300
aaagaaacaa gcgaaatcaa gacccaagaa gttttctttg gtgatttccc aatcatgaca   360
gaaatgggta ctttcatcat caatggtggt gaacgtatta tcgtttctca gttggtccgc   420
tcaccaggtg tttactttaa cgacaaagta gacaaaaatg gtaaggtggg ctatggttca   480
actgttatcc ctaaccgtgg agcttggttg gaacttgaaa gcgactcaaa agatatcacc   540
tacactcgta tcgaccgtac tcgtaagatt ccatttacaa ccttggttcg tgctcttggt   600
ttctcaggtg atgatgaaat ctttgatatc tttggtgaca gcgaattggt tcgcaacact   660
gttgaaaaag atatccacaa gaatccaatg gactctcgta cagacgaagc cttgaaagaa   720
atttacgaac gccttcgtcc aggtgagcct aagacggctg aaagctcacg tagcttgctt   780
gtagctcgct tctttgaccc acgtcgttat gacttggcag cagttggtcg ttacaaaatc   840
aataaaaaac tcaatgttaa aacacgtttg ctcaaccaaa ccattgcaga gccattggta   900
gaccctgaaa ctggagaaat cttggtagaa gctggtacga ttatgactcg tagcgtgatt   960
gaaagcattg aaagccattt ggatggcgac ttgaacaaga ttgtctacat cccaaacgat   1020
gcagccgttg tgactgagcc tgttgttctt caaaaattca aggttattgc tccaactgat   1080
ccagatcgcg tcgtaacgat cattggtaat gctaacccag atgacaaggt tcgtacggtg   1140
actcctgcag atatccttgc tgagatgagc tacttcctca acttggctga aggacttggc   1200
cgtgtagatg atatcgacca ccttggaaat cgtcgtatcc gtgcggttgg tgaattgctt   1260
gccaaccaag tacgtttggg actttctcgt atggaacgta atgtccgtga acgtatgtct   1320
gttcaggaca atgaagtctt gacaccacaa caaattatca atatccgtcc tgtaacagct   1380
gcagttaaag aattctttgg ttcatcacag ttgtcacagt tcatggacca acacaacccg   1440
ctttctgagt tgtctcacaa acgccgtttg tcagccttag gacctggtgg tttgactcgt   1500
gaccgtgctg gatatgaagt acgtgacgtg cactacactc actatggtcg tatgtgtcca   1560
atcgagacac ctgaaggacc taacatcggt ttgatcaata acttgtcatc ttatggacac   1620
ttgaacaaat atggttttgt tcaaacacca taccgtaagg ttgaccgtga aacaggtgtt   1680
gtcacgaacg aaattgtttg gttgacagct gatgaagaag atgaatatac tgtagctcag   1740
gctaactctc gtctgaatga agatggaacc tttgctgaga agattgtcat gggacgtcac   1800
caaggggtca accaagagta tccagctaat attgttgact acatggacgt ttcaccaaaa   1860
caggtagttg ccgttgcgac agcatgtatt cctttcttgg aaaacgatga ctccaaccgt   1920
gccctcatgg gagccaatat gcaacgtcag gctgtgccat tgattaatcc tcaggcacct   1980
tacgttggta ctggtatgga ataccaagca gcccacgatt ctggtgcggc tgtgattgct   2040
cagtatgatg gtaaagttac ttacgcagat gctgacaagg tagaagttcg tcgtgaagat   2100
ggttcattgg atgtttacca catccaaaaa ttccgtcgtt caaactcagg tactgcttac   2160
aaccaacgca ctctcgtaaa agttggtgat gtcgttgaaa aaggcgattt catcgctgac   2220
ggaccttcta tggaaaatgg agaaatggcg cttggacaaa acccaatcgt tgcctacatg   2280
acttgggaag gttacaactt cgaggatgcc gttatcatga gcgaacgctt ggtgaaggac   2340
gatgtctaca catctgttca ccttgaagaa tacgaatcag aaacgcgcga tacaaagctt   2400
gggcctgaag aaatcactcg cgaaattcca aacgttggtg aagatgccct caaagacctt   2460
gacgaaatgg ggattatccg tattggtgct gaggttaaag aaggtgatat tcttgtaggt   2520
aaagtaacac ctaagggtga gaaagatctt tcagctgaag aacgtctctt gcacgctatc   2580
tttggagaca agtctcgtga agtgcgtgat acttctcttc gtgtaccaca cggtgccgat   2640
ggtgtcgttc gtgatgttaa gatctttaca cgtgtaaatg gagatgagtt gcaatcaggt   2700
gttaacatgt tggttcgtgt ttacatcgct caaaaacgta agattaaggt cggagataaa   2760
atggccggac gtcacggaaa caaaggggtt gtctctcgta tcgttcctgt agaagacatg   2820
ccttaccttc cagacggaac tccagtcgac atcatgttga acccacttgg ggtaccatca   2880
cgtatgaata tcggtcaggt tatggagctt caccttggta tggcagctcg tactcttggt   2940
attcacatcg ctacaccagt ctttgatgga gcaagttctg aagatctttg gtcaactgtt   3000
aaagaagcag gtatggatag cgatgccaaa acgatccttt acgatggacg tactggtgaa   3060
ccgtttgata accgtgtttc tgtcggagtc atgtacatga tcaaactcca ccacatggtt   3120
gatgataaat tgcacgcgcg ttcagtcgga ccatactcaa ctgttaccca acaaccactc   3180
ggaggtaagg ctcagtttgg tggacaacgt ttcggtgaga tggaggtttg ggctcttgaa   3240
gcctacggtg cgtcaaatgt ccttcaagaa atcttgactt acaagtcgga cgatatcaac   3300
ggacgtttga aagcctatga agctattaca aaaggcaaac caattccaaa accaggtgtt   3360
ccagaatcct tccgagttct tgtcaaagaa ttgcaatctc ttggtcttga catgcgtgtc   3420
ctagacgaag atgaccaaga agtggaactt cgcgacttgg atgaaggaat ggacgaagat   3480
gtcatccacg tagatgacct tgaaaaagcc cgcgaaaaag cagcccaaga ggctaaagca   3540
gcctttgaag ctgaagaagc tgagaaagca acaaaagcgg aagcaacaga agaagctgct   3600
gaacaagaa                                                           3609

<210>   4086
<211>   1203
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-directed RNA polymerase, beta subunit (rpoB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903819 (0.E+01)

<400>   4086
Met Ala Gly His Asp Val Gln Tyr Gly Lys His Arg Thr Arg Arg Ser 
1               5                   10                  15      

Phe Ser Arg Ile Lys Glu Val Leu Asp Leu Pro Asn Leu Ile Glu Ile 
            20                  25                  30          

Gln Thr Asp Ser Phe Lys Ala Phe Leu Asp His Gly Leu Lys Glu Val 
        35                  40                  45              

Phe Glu Asp Val Leu Pro Ile Ser Asn Phe Thr Asp Thr Met Glu Leu 
    50                  55                  60                  

Glu Phe Val Gly Tyr Glu Ile Lys Glu Pro Lys Tyr Thr Leu Glu Glu 
65                  70                  75                  80  

Ala Arg Ile His Asp Ala Ser Tyr Ser Ala Pro Ile Phe Val Thr Phe 
                85                  90                  95      

Arg Leu Ile Asn Lys Glu Thr Ser Glu Ile Lys Thr Gln Glu Val Phe 
            100                 105                 110         

Phe Gly Asp Phe Pro Ile Met Thr Glu Met Gly Thr Phe Ile Ile Asn 
        115                 120                 125             

Gly Gly Glu Arg Ile Ile Val Ser Gln Leu Val Arg Ser Pro Gly Val 
    130                 135                 140                 

Tyr Phe Asn Asp Lys Val Asp Lys Asn Gly Lys Val Gly Tyr Gly Ser 
145                 150                 155                 160 

Thr Val Ile Pro Asn Arg Gly Ala Trp Leu Glu Leu Glu Ser Asp Ser 
                165                 170                 175     

Lys Asp Ile Thr Tyr Thr Arg Ile Asp Arg Thr Arg Lys Ile Pro Phe 
            180                 185                 190         

Thr Thr Leu Val Arg Ala Leu Gly Phe Ser Gly Asp Asp Glu Ile Phe 
        195                 200                 205             

Asp Ile Phe Gly Asp Ser Glu Leu Val Arg Asn Thr Val Glu Lys Asp 
    210                 215                 220                 

Ile His Lys Asn Pro Met Asp Ser Arg Thr Asp Glu Ala Leu Lys Glu 
225                 230                 235                 240 

Ile Tyr Glu Arg Leu Arg Pro Gly Glu Pro Lys Thr Ala Glu Ser Ser 
                245                 250                 255     

Arg Ser Leu Leu Val Ala Arg Phe Phe Asp Pro Arg Arg Tyr Asp Leu 
            260                 265                 270         

Ala Ala Val Gly Arg Tyr Lys Ile Asn Lys Lys Leu Asn Val Lys Thr 
        275                 280                 285             

Arg Leu Leu Asn Gln Thr Ile Ala Glu Pro Leu Val Asp Pro Glu Thr 
    290                 295                 300                 

Gly Glu Ile Leu Val Glu Ala Gly Thr Ile Met Thr Arg Ser Val Ile 
305                 310                 315                 320 

Glu Ser Ile Glu Ser His Leu Asp Gly Asp Leu Asn Lys Ile Val Tyr 
                325                 330                 335     

Ile Pro Asn Asp Ala Ala Val Val Thr Glu Pro Val Val Leu Gln Lys 
            340                 345                 350         

Phe Lys Val Ile Ala Pro Thr Asp Pro Asp Arg Val Val Thr Ile Ile 
        355                 360                 365             

Gly Asn Ala Asn Pro Asp Asp Lys Val Arg Thr Val Thr Pro Ala Asp 
    370                 375                 380                 

Ile Leu Ala Glu Met Ser Tyr Phe Leu Asn Leu Ala Glu Gly Leu Gly 
385                 390                 395                 400 


Arg Val Asp Asp Ile Asp His Leu Gly Asn Arg Arg Ile Arg Ala Val 
                405                 410                 415     

Gly Glu Leu Leu Ala Asn Gln Val Arg Leu Gly Leu Ser Arg Met Glu 
            420                 425                 430         

Arg Asn Val Arg Glu Arg Met Ser Val Gln Asp Asn Glu Val Leu Thr 
        435                 440                 445             

Pro Gln Gln Ile Ile Asn Ile Arg Pro Val Thr Ala Ala Val Lys Glu 
    450                 455                 460                 

Phe Phe Gly Ser Ser Gln Leu Ser Gln Phe Met Asp Gln His Asn Pro 
465                 470                 475                 480 

Leu Ser Glu Leu Ser His Lys Arg Arg Leu Ser Ala Leu Gly Pro Gly 
                485                 490                 495     

Gly Leu Thr Arg Asp Arg Ala Gly Tyr Glu Val Arg Asp Val His Tyr 
            500                 505                 510         

Thr His Tyr Gly Arg Met Cys Pro Ile Glu Thr Pro Glu Gly Pro Asn 
        515                 520                 525             

Ile Gly Leu Ile Asn Asn Leu Ser Ser Tyr Gly His Leu Asn Lys Tyr 
    530                 535                 540                 

Gly Phe Val Gln Thr Pro Tyr Arg Lys Val Asp Arg Glu Thr Gly Val 
545                 550                 555                 560 

Val Thr Asn Glu Ile Val Trp Leu Thr Ala Asp Glu Glu Asp Glu Tyr 
                565                 570                 575     

Thr Val Ala Gln Ala Asn Ser Arg Leu Asn Glu Asp Gly Thr Phe Ala 
            580                 585                 590         

Glu Lys Ile Val Met Gly Arg His Gln Gly Val Asn Gln Glu Tyr Pro 
        595                 600                 605             

Ala Asn Ile Val Asp Tyr Met Asp Val Ser Pro Lys Gln Val Val Ala 
    610                 615                 620                 

Val Ala Thr Ala Cys Ile Pro Phe Leu Glu Asn Asp Asp Ser Asn Arg 
625                 630                 635                 640 

Ala Leu Met Gly Ala Asn Met Gln Arg Gln Ala Val Pro Leu Ile Asn 
                645                 650                 655     

Pro Gln Ala Pro Tyr Val Gly Thr Gly Met Glu Tyr Gln Ala Ala His 
            660                 665                 670         

Asp Ser Gly Ala Ala Val Ile Ala Gln Tyr Asp Gly Lys Val Thr Tyr 
        675                 680                 685             

Ala Asp Ala Asp Lys Val Glu Val Arg Arg Glu Asp Gly Ser Leu Asp 
    690                 695                 700                 

Val Tyr His Ile Gln Lys Phe Arg Arg Ser Asn Ser Gly Thr Ala Tyr 
705                 710                 715                 720 

Asn Gln Arg Thr Leu Val Lys Val Gly Asp Val Val Glu Lys Gly Asp 
                725                 730                 735     


Phe Ile Ala Asp Gly Pro Ser Met Glu Asn Gly Glu Met Ala Leu Gly 
            740                 745                 750         

Gln Asn Pro Ile Val Ala Tyr Met Thr Trp Glu Gly Tyr Asn Phe Glu 
        755                 760                 765             

Asp Ala Val Ile Met Ser Glu Arg Leu Val Lys Asp Asp Val Tyr Thr 
    770                 775                 780                 

Ser Val His Leu Glu Glu Tyr Glu Ser Glu Thr Arg Asp Thr Lys Leu 
785                 790                 795                 800 

Gly Pro Glu Glu Ile Thr Arg Glu Ile Pro Asn Val Gly Glu Asp Ala 
                805                 810                 815     

Leu Lys Asp Leu Asp Glu Met Gly Ile Ile Arg Ile Gly Ala Glu Val 
            820                 825                 830         

Lys Glu Gly Asp Ile Leu Val Gly Lys Val Thr Pro Lys Gly Glu Lys 
        835                 840                 845             

Asp Leu Ser Ala Glu Glu Arg Leu Leu His Ala Ile Phe Gly Asp Lys 
    850                 855                 860                 

Ser Arg Glu Val Arg Asp Thr Ser Leu Arg Val Pro His Gly Ala Asp 
865                 870                 875                 880 

Gly Val Val Arg Asp Val Lys Ile Phe Thr Arg Val Asn Gly Asp Glu 
                885                 890                 895     

Leu Gln Ser Gly Val Asn Met Leu Val Arg Val Tyr Ile Ala Gln Lys 
            900                 905                 910         

Arg Lys Ile Lys Val Gly Asp Lys Met Ala Gly Arg His Gly Asn Lys 
        915                 920                 925             

Gly Val Val Ser Arg Ile Val Pro Val Glu Asp Met Pro Tyr Leu Pro 
    930                 935                 940                 

Asp Gly Thr Pro Val Asp Ile Met Leu Asn Pro Leu Gly Val Pro Ser 
945                 950                 955                 960 

Arg Met Asn Ile Gly Gln Val Met Glu Leu His Leu Gly Met Ala Ala 
                965                 970                 975     

Arg Thr Leu Gly Ile His Ile Ala Thr Pro Val Phe Asp Gly Ala Ser 
            980                 985                 990         

Ser Glu Asp Leu Trp Ser Thr Val Lys Glu Ala Gly Met Asp Ser Asp 
        995                 1000                1005            

Ala Lys Thr Ile Leu Tyr Asp Gly Arg Thr Gly Glu Pro Phe Asp Asn 
    1010                1015                1020                

Arg Val Ser Val Gly Val Met Tyr Met Ile Lys Leu His His Met Val 
1025                1030                1035                1040

Asp Asp Lys Leu His Ala Arg Ser Val Gly Pro Tyr Ser Thr Val Thr 
                1045                1050                1055    

Gln Gln Pro Leu Gly Gly Lys Ala Gln Phe Gly Gly Gln Arg Phe Gly 
            1060                1065                1070        

Glu Met Glu Val Trp Ala Leu Glu Ala Tyr Gly Ala Ser Asn Val Leu 
        1075                1080                1085            

Gln Glu Ile Leu Thr Tyr Lys Ser Asp Asp Ile Asn Gly Arg Leu Lys 
    1090                1095                1100                

Ala Tyr Glu Ala Ile Thr Lys Gly Lys Pro Ile Pro Lys Pro Gly Val 
1105                1110                1115                1120

Pro Glu Ser Phe Arg Val Leu Val Lys Glu Leu Gln Ser Leu Gly Leu 
                1125                1130                1135    

Asp Met Arg Val Leu Asp Glu Asp Asp Gln Glu Val Glu Leu Arg Asp 
            1140                1145                1150        

Leu Asp Glu Gly Met Asp Glu Asp Val Ile His Val Asp Asp Leu Glu 
        1155                1160                1165            

Lys Ala Arg Glu Lys Ala Ala Gln Glu Ala Lys Ala Ala Phe Glu Ala 
    1170                1175                1180                

Glu Glu Ala Glu Lys Ala Thr Lys Ala Glu Ala Thr Glu Glu Ala Ala 
1185                1190                1195                1200

Glu Gln Glu 
            

<210>   4087
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4087
ttgatcgtcg gttcaaatcc gtctaccgcc ttctataact tgatttatca ggtttcaaat   60
gaacagaaag cccaatttga agggcttttt ttattttccc tcgaa                   105

<210>   4088
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4088
Met Ile Val Gly Ser Asn Pro Ser Thr Ala Phe Tyr Asn Leu Ile Tyr 
1               5                   10                  15      

Gln Val Ser Asn Glu Gln Lys Ala Gln Phe Glu Gly Leu Phe Leu Phe 
            20                  25                  30          

Ser Leu Glu 
        35  

<210>   4089
<211>   1329
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4089
atggaagacc caagtagtca gaatttgttg ctacaatttg ttttattgtt tatcttgacg   60
gtattaaatg cctttttctc agccacagaa atggccatgg tttctcttaa tcgtgcccga   120
gttgaacaaa aggcggaaga aggagacaga cgctacatcc gcctgctgaa ggtactagaa   180
aatcctaacc actttttatc aaccatccag gtaggaatca ccctgattac aatcttatca   240
ggggcgagtt taactgatac tctaggacgt gtgattgcct cttggcttgg gaatggcgaa   300
acagcacaag ccgtggcaac ttttctatcc ttggcatttt tgacctatat ttccatcgtt   360
tttggggaat tatatcctaa gagaatcgct cttaatctaa aggatgcctt ggcaattcgt   420
acagcgccga ttatcattgg gatcggaaaa ctagtcagtc cttttgtttg gcttttagct   480
gcttcgacca atttcttgag ccatttgact cctatgtcat tcgatgatgc ggatgaaaag   540
atgacccgtg atgaaattgc ctatatgctg acaaatagtg aagaaacatt ggatgctgat   600
gagattgaga tgctacaagg tgtcttttcg ctcgatgaac tgatggcacg agaggttatg   660
gttcctcgaa cggatgcctt tatggtggat attcaggatg atagtcaagc cattatccaa   720
agtattttaa aacaaaatta ttctcgtatc ccggtttatg atggggataa ggacaatgta   780
attggaatca ttcacaccaa gagtctcctt aaggcaggct ttgtggacgg ttttgacaat   840
attgtttgga agagaatttt acaagatcca ctttttgtac ctgaaactat ttttgtggat   900
gacttgctaa aagaactgcg aaatacccaa agacaaatgg caatcttgct ggatgaatac   960
ggtggtatgg ctggtttggt gactttggaa gacctcttag aggaaattgt tggtgaaatt   1020
gatgatgaaa cggacaaagc agcaatagat gttcatcaga ttggcgagga tacctacatt   1080
gttcaaggaa ctatgaccct caatgatttc aataattact ttgatgttga actggaaagt   1140
gatgacgttg atactatcgc tggttattat ttgacaggag tgggaactat tccaacgact   1200
gagaaactca gctatgaatt ggtcagccaa aacaaacagt ttatcttaac caatgataaa   1260
gtgaagaatg gacgtgttac caaggtaaaa gtccaaatca cagaagtcga aatagaagaa   1320
gaaacagaa                                                           1329

<210>   4090
<211>   443
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   CBS domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903820 (0.E+01)

<400>   4090
Met Glu Asp Pro Ser Ser Gln Asn Leu Leu Leu Gln Phe Val Leu Leu 
1               5                   10                  15      

Phe Ile Leu Thr Val Leu Asn Ala Phe Phe Ser Ala Thr Glu Met Ala 
            20                  25                  30          

Met Val Ser Leu Asn Arg Ala Arg Val Glu Gln Lys Ala Glu Glu Gly 
        35                  40                  45              

Asp Arg Arg Tyr Ile Arg Leu Leu Lys Val Leu Glu Asn Pro Asn His 
    50                  55                  60                  

Phe Leu Ser Thr Ile Gln Val Gly Ile Thr Leu Ile Thr Ile Leu Ser 
65                  70                  75                  80  

Gly Ala Ser Leu Thr Asp Thr Leu Gly Arg Val Ile Ala Ser Trp Leu 
                85                  90                  95      

Gly Asn Gly Glu Thr Ala Gln Ala Val Ala Thr Phe Leu Ser Leu Ala 
            100                 105                 110         

Phe Leu Thr Tyr Ile Ser Ile Val Phe Gly Glu Leu Tyr Pro Lys Arg 
        115                 120                 125             

Ile Ala Leu Asn Leu Lys Asp Ala Leu Ala Ile Arg Thr Ala Pro Ile 
    130                 135                 140                 

Ile Ile Gly Ile Gly Lys Leu Val Ser Pro Phe Val Trp Leu Leu Ala 
145                 150                 155                 160 

Ala Ser Thr Asn Phe Leu Ser His Leu Thr Pro Met Ser Phe Asp Asp 
                165                 170                 175     

Ala Asp Glu Lys Met Thr Arg Asp Glu Ile Ala Tyr Met Leu Thr Asn 
            180                 185                 190         

Ser Glu Glu Thr Leu Asp Ala Asp Glu Ile Glu Met Leu Gln Gly Val 
        195                 200                 205             

Phe Ser Leu Asp Glu Leu Met Ala Arg Glu Val Met Val Pro Arg Thr 
    210                 215                 220                 

Asp Ala Phe Met Val Asp Ile Gln Asp Asp Ser Gln Ala Ile Ile Gln 
225                 230                 235                 240 

Ser Ile Leu Lys Gln Asn Tyr Ser Arg Ile Pro Val Tyr Asp Gly Asp 
                245                 250                 255     

Lys Asp Asn Val Ile Gly Ile Ile His Thr Lys Ser Leu Leu Lys Ala 
            260                 265                 270         

Gly Phe Val Asp Gly Phe Asp Asn Ile Val Trp Lys Arg Ile Leu Gln 
        275                 280                 285             

Asp Pro Leu Phe Val Pro Glu Thr Ile Phe Val Asp Asp Leu Leu Lys 
    290                 295                 300                 

Glu Leu Arg Asn Thr Gln Arg Gln Met Ala Ile Leu Leu Asp Glu Tyr 
305                 310                 315                 320 

Gly Gly Met Ala Gly Leu Val Thr Leu Glu Asp Leu Leu Glu Glu Ile 
                325                 330                 335     

Val Gly Glu Ile Asp Asp Glu Thr Asp Lys Ala Ala Ile Asp Val His 
            340                 345                 350         

Gln Ile Gly Glu Asp Thr Tyr Ile Val Gln Gly Thr Met Thr Leu Asn 
        355                 360                 365             

Asp Phe Asn Asn Tyr Phe Asp Val Glu Leu Glu Ser Asp Asp Val Asp 
    370                 375                 380                 

Thr Ile Ala Gly Tyr Tyr Leu Thr Gly Val Gly Thr Ile Pro Thr Thr 
385                 390                 395                 400 

Glu Lys Leu Ser Tyr Glu Leu Val Ser Gln Asn Lys Gln Phe Ile Leu 
                405                 410                 415     

Thr Asn Asp Lys Val Lys Asn Gly Arg Val Thr Lys Val Lys Val Gln 
            420                 425                 430         

Ile Thr Glu Val Glu Ile Glu Glu Glu Thr Glu 
        435                 440             

<210>   4091
<211>   822
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4091
atgaacaaaa aaacaagaca gacactaatc ggactgctag tgttattgct tttgtctaca   60
gggagctatt atatcaagca gatgccgtcg gcacctaata gtcccaaaac caatcttagt   120
cagaaaaaac aagcgtctga agctcctagt caagcattgg cagagagtgt cttaacagac   180
gcagtcaaga gtcaaataaa ggggagtctg gagtggaatg gctcaggtgc ttttatcgtc   240
aatggtaata aaacaaatct agatgccaag gtttcaagta agccctacgc tgacaataaa   300
acaaagacag tgggcaagga aactgttcca accgtagcta atgccctctt gtctaaggcc   360
actcgtcagt acaagaatcg taaagaaact gggaatggtt caacttcttg gactcctcca   420
ggttggcatc aggtcaagaa tctaaagggc tcttataccc atgcagtcga tagaggtcat   480
ttgttaggct atgccttaat cggtggtttg gatggttttg atgcctcaac aagcaatcct   540
aaaaacattg ctgttcagac agcctgggca aatcaggcac aagccgagta ttcgactggt   600
caaaactact atgaaagcaa ggtgcgtaaa gccttggacc aaaacaagcg tgtccgttac   660
cgtgtaaccc tttactacgc ttcaaacgag gatttagttc cctcagcttc acagattgaa   720
gccaagtctt cggatggaga attggaattc aatgttctag ttcccaatgt tcaaaaggga   780
cttcaactgg attaccgaac tggagaagta actgtaactc ag                      822

<210>   4092
<211>   274
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-entry nuclease (endA)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903821 (e-156)

<400>   4092
Met Asn Lys Lys Thr Arg Gln Thr Leu Ile Gly Leu Leu Val Leu Leu 
1               5                   10                  15      

Leu Leu Ser Thr Gly Ser Tyr Tyr Ile Lys Gln Met Pro Ser Ala Pro 
            20                  25                  30          

Asn Ser Pro Lys Thr Asn Leu Ser Gln Lys Lys Gln Ala Ser Glu Ala 
        35                  40                  45              

Pro Ser Gln Ala Leu Ala Glu Ser Val Leu Thr Asp Ala Val Lys Ser 
    50                  55                  60                  

Gln Ile Lys Gly Ser Leu Glu Trp Asn Gly Ser Gly Ala Phe Ile Val 
65                  70                  75                  80  

Asn Gly Asn Lys Thr Asn Leu Asp Ala Lys Val Ser Ser Lys Pro Tyr 
                85                  90                  95      

Ala Asp Asn Lys Thr Lys Thr Val Gly Lys Glu Thr Val Pro Thr Val 
            100                 105                 110         

Ala Asn Ala Leu Leu Ser Lys Ala Thr Arg Gln Tyr Lys Asn Arg Lys 
        115                 120                 125             

Glu Thr Gly Asn Gly Ser Thr Ser Trp Thr Pro Pro Gly Trp His Gln 
    130                 135                 140                 

Val Lys Asn Leu Lys Gly Ser Tyr Thr His Ala Val Asp Arg Gly His 
145                 150                 155                 160 

Leu Leu Gly Tyr Ala Leu Ile Gly Gly Leu Asp Gly Phe Asp Ala Ser 
                165                 170                 175     

Thr Ser Asn Pro Lys Asn Ile Ala Val Gln Thr Ala Trp Ala Asn Gln 
            180                 185                 190         

Ala Gln Ala Glu Tyr Ser Thr Gly Gln Asn Tyr Tyr Glu Ser Lys Val 
        195                 200                 205             

Arg Lys Ala Leu Asp Gln Asn Lys Arg Val Arg Tyr Arg Val Thr Leu 
    210                 215                 220                 

Tyr Tyr Ala Ser Asn Glu Asp Leu Val Pro Ser Ala Ser Gln Ile Glu 
225                 230                 235                 240 

Ala Lys Ser Ser Asp Gly Glu Leu Glu Phe Asn Val Leu Val Pro Asn 
                245                 250                 255     

Val Gln Lys Gly Leu Gln Leu Asp Tyr Arg Thr Gly Glu Val Thr Val 
            260                 265                 270         

Thr Gln 
        

<210>   4093
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4093
ttgaggcaag tgatgaagat gaataagaaa tcaagctacg tagtcaagcg tttactttta   60
gtcatcatag tactgatttt aggtactctg gctctaggaa tcggtttaat ggtaggttat   120
ggaatcttgg gcaagggtca agatccatgg gctatcctgt ctccagcaaa atggcaggaa   180
ttgattcata aatttacagg aaat                                          204

<210>   4094
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903822 (2.E-34)

<400>   4094
Met Arg Gln Val Met Lys Met Asn Lys Lys Ser Ser Tyr Val Val Lys 
1               5                   10                  15      

Arg Leu Leu Leu Val Ile Ile Val Leu Ile Leu Gly Thr Leu Ala Leu 
            20                  25                  30          

Gly Ile Gly Leu Met Val Gly Tyr Gly Ile Leu Gly Lys Gly Gln Asp 
        35                  40                  45              

Pro Trp Ala Ile Leu Ser Pro Ala Lys Trp Gln Glu Leu Ile His Lys 
    50                  55                  60                  

Phe Thr Gly Asn 
65              

<210>   4095
<211>   1308
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4095
atgaaatcaa gagtaaagga aacgagtatg gataaaattg tggttcaagg tggcgataat   60
cgtctggtag gaagcgtgac gatcgaggga gcaaaaaatg cagtcttacc cttgttggca   120
gcgactattc tagcaagtga aggaaagacc gtcttgcaga atgttccgat tttgtcggat   180
gtctttatta tgaatcaggt agttggtggt ttgaatgcca aggttgactt tgatgaggaa   240
gctcatcttg tcaaggtgga tgctactggc gacatcactg aggaagcccc ttacaagtat   300
gtcagcaaga tgcgcgcctc catcgttgta ttagggccaa tccttgcccg tgtgggtcat   360
gccaaggtat ccatgccagg tggttgtacg attggtagcc gtcctattga tcttcatttg   420
aaaggtctgg aagctatggg ggttaagatt agtcagacag ctggttacat cgaagccaag   480
gcagaacgct tgcatggtgc tcatatctat atggactttc caagtgttgg tgcaacgcag   540
aacttgatga tggcagcgac tctggctgat ggggtgacag tgattgagaa tgctgcgcgt   600
gagcctgaga ttgttgactt agccattctc cttaatgaaa tgggagccaa ggtcaaaggt   660
gctggtacag agactataac cattactggt gttgagaaac ttcatggtac gactcacaat   720
gtagtccaag accgtatcga agcaggaacc tttatggtag ctgctgccat gactggtggt   780
gatgtcttga ttcgagacgc tgtctgggag cacaaccgtc ccttgattgc caagttactt   840
gaaatgggtg ttgaagtaat tgaagaagac gaaggaattc gtgttcgttc tcaactagaa   900
aatctaaaag ctgttcatgt gaaaaccttg ccccacccag gatttccaac agatatgcag   960
gctcaattta cagccttgat gacagttgca aaaggcgaat caaccatggt ggagacagtt   1020
ttcgaaaatc gtttccaaca cctagaagag atgcgccgca tgggcttgca ttctgagatt   1080
atccgtgata cagctcgtat tgttggtgga cagcctttgc agggagcaga agttctttca   1140
actgaccttc gtgccagtgc ggccttgatt ttgacaggtt tggtagcaca gggagaaact   1200
gtggtcggta aattggttca cttggataga ggttactacg gtttccatga gaagttggcg   1260
cagctaggtg ctaagattca gcggattgag gcaagtgatg aagatgaa                1308

<210>   4096
<211>   436
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UDP-N-acetylglucosamine 1-carboxyvinyltransferase (murA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903823 (0.E+01)

<400>   4096
Met Lys Ser Arg Val Lys Glu Thr Ser Met Asp Lys Ile Val Val Gln 
1               5                   10                  15      

Gly Gly Asp Asn Arg Leu Val Gly Ser Val Thr Ile Glu Gly Ala Lys 
            20                  25                  30          

Asn Ala Val Leu Pro Leu Leu Ala Ala Thr Ile Leu Ala Ser Glu Gly 
        35                  40                  45              

Lys Thr Val Leu Gln Asn Val Pro Ile Leu Ser Asp Val Phe Ile Met 
    50                  55                  60                  

Asn Gln Val Val Gly Gly Leu Asn Ala Lys Val Asp Phe Asp Glu Glu 
65                  70                  75                  80  

Ala His Leu Val Lys Val Asp Ala Thr Gly Asp Ile Thr Glu Glu Ala 
                85                  90                  95      

Pro Tyr Lys Tyr Val Ser Lys Met Arg Ala Ser Ile Val Val Leu Gly 
            100                 105                 110         

Pro Ile Leu Ala Arg Val Gly His Ala Lys Val Ser Met Pro Gly Gly 
        115                 120                 125             

Cys Thr Ile Gly Ser Arg Pro Ile Asp Leu His Leu Lys Gly Leu Glu 
    130                 135                 140                 

Ala Met Gly Val Lys Ile Ser Gln Thr Ala Gly Tyr Ile Glu Ala Lys 
145                 150                 155                 160 

Ala Glu Arg Leu His Gly Ala His Ile Tyr Met Asp Phe Pro Ser Val 
                165                 170                 175     

Gly Ala Thr Gln Asn Leu Met Met Ala Ala Thr Leu Ala Asp Gly Val 
            180                 185                 190         

Thr Val Ile Glu Asn Ala Ala Arg Glu Pro Glu Ile Val Asp Leu Ala 
        195                 200                 205             

Ile Leu Leu Asn Glu Met Gly Ala Lys Val Lys Gly Ala Gly Thr Glu 
    210                 215                 220                 

Thr Ile Thr Ile Thr Gly Val Glu Lys Leu His Gly Thr Thr His Asn 
225                 230                 235                 240 

Val Val Gln Asp Arg Ile Glu Ala Gly Thr Phe Met Val Ala Ala Ala 
                245                 250                 255     

Met Thr Gly Gly Asp Val Leu Ile Arg Asp Ala Val Trp Glu His Asn 
            260                 265                 270         

Arg Pro Leu Ile Ala Lys Leu Leu Glu Met Gly Val Glu Val Ile Glu 
        275                 280                 285             

Glu Asp Glu Gly Ile Arg Val Arg Ser Gln Leu Glu Asn Leu Lys Ala 
    290                 295                 300                 

Val His Val Lys Thr Leu Pro His Pro Gly Phe Pro Thr Asp Met Gln 
305                 310                 315                 320 

Ala Gln Phe Thr Ala Leu Met Thr Val Ala Lys Gly Glu Ser Thr Met 
                325                 330                 335     

Val Glu Thr Val Phe Glu Asn Arg Phe Gln His Leu Glu Glu Met Arg 
            340                 345                 350         

Arg Met Gly Leu His Ser Glu Ile Ile Arg Asp Thr Ala Arg Ile Val 
        355                 360                 365             

Gly Gly Gln Pro Leu Gln Gly Ala Glu Val Leu Ser Thr Asp Leu Arg 
    370                 375                 380                 

Ala Ser Ala Ala Leu Ile Leu Thr Gly Leu Val Ala Gln Gly Glu Thr 
385                 390                 395                 400 

Val Val Gly Lys Leu Val His Leu Asp Arg Gly Tyr Tyr Gly Phe His 
                405                 410                 415     

Glu Lys Leu Ala Gln Leu Gly Ala Lys Ile Gln Arg Ile Glu Ala Ser 
            420                 425                 430         

Asp Glu Asp Glu 
        435     

<210>   4097
<211>   1035
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4097
atgaaaaaaa agattagatg gcccttatac gtcattgcgg ccttgattgt gactttcttg   60
gcatttgtag tgcccttgcc ttattatata gaggttccag gtggttcgga agatattcgc   120
caagtcctta aagtaaatga cacagaagat aaggaagctg gtgcctatca attcgttacg   180
gttggtgttc aacatgccac tttagctcat atgatttatg cttggttgac accttttaca   240
gatattcgta gtgctcagga gactacaggt ggttcttccg atgttgaatt tatgcgaatc   300
aatcaattct acatgcaaac atcgcaaaat atggccaagt atcaaggact aaaaacagct   360
ggtaaggata tcgaactcaa gtactttgga gtttatgttt tgaatgtgac ggataattca   420
acctttaaag ggattctcaa tatctctgat acagtcacag cagtcaatga tcagaccttt   480
gatagttcca aagacttgat tgattacgtc agttctcaaa aattagggga ttccgtcaag   540
gtcacctatg aagaggatgg gcaaaccaag tctgcagaag gaaaaatcat caccttggaa   600
aatggcaaaa atggaattgg aatcggcttg attgaccgta cagaggtaat cagcaatgtc   660
ccaattagct tttcaacagc tggtattggc ggtccaagtg ctggtctcat gtttagtcta   720
gctatctata ctcaaatagc tcacccagat cttcgtaatg gtcgtattgt tgccggtaca   780
ggtaccattg accgcgatgg taatgtggga gacattggag gtattgataa gaaggttgta   840
gcttcggcta gggcaggtgc tgctattttc tttgctcctg ataaccctgt tagcgaagaa   900
gaacaaaagg cgcatccgga cgcgaaaaac aactaccaaa cagccctaga agcggctaaa   960
acaatcaaga cggatatgaa aatcgtgccc gttaaaaccc tacaagatgc gattgattac   1020
ttgaaaaaca atccc                                                    1035

<210>   4098
<211>   345
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903824 (0.E+01)

<400>   4098
Met Lys Lys Lys Ile Arg Trp Pro Leu Tyr Val Ile Ala Ala Leu Ile 
1               5                   10                  15      

Val Thr Phe Leu Ala Phe Val Val Pro Leu Pro Tyr Tyr Ile Glu Val 
            20                  25                  30          

Pro Gly Gly Ser Glu Asp Ile Arg Gln Val Leu Lys Val Asn Asp Thr 
        35                  40                  45              

Glu Asp Lys Glu Ala Gly Ala Tyr Gln Phe Val Thr Val Gly Val Gln 
    50                  55                  60                  

His Ala Thr Leu Ala His Met Ile Tyr Ala Trp Leu Thr Pro Phe Thr 
65                  70                  75                  80  

Asp Ile Arg Ser Ala Gln Glu Thr Thr Gly Gly Ser Ser Asp Val Glu 
                85                  90                  95      

Phe Met Arg Ile Asn Gln Phe Tyr Met Gln Thr Ser Gln Asn Met Ala 
            100                 105                 110         

Lys Tyr Gln Gly Leu Lys Thr Ala Gly Lys Asp Ile Glu Leu Lys Tyr 
        115                 120                 125             

Phe Gly Val Tyr Val Leu Asn Val Thr Asp Asn Ser Thr Phe Lys Gly 
    130                 135                 140                 

Ile Leu Asn Ile Ser Asp Thr Val Thr Ala Val Asn Asp Gln Thr Phe 
145                 150                 155                 160 

Asp Ser Ser Lys Asp Leu Ile Asp Tyr Val Ser Ser Gln Lys Leu Gly 
                165                 170                 175     

Asp Ser Val Lys Val Thr Tyr Glu Glu Asp Gly Gln Thr Lys Ser Ala 
            180                 185                 190         

Glu Gly Lys Ile Ile Thr Leu Glu Asn Gly Lys Asn Gly Ile Gly Ile 
        195                 200                 205             

Gly Leu Ile Asp Arg Thr Glu Val Ile Ser Asn Val Pro Ile Ser Phe 
    210                 215                 220                 

Ser Thr Ala Gly Ile Gly Gly Pro Ser Ala Gly Leu Met Phe Ser Leu 
225                 230                 235                 240 

Ala Ile Tyr Thr Gln Ile Ala His Pro Asp Leu Arg Asn Gly Arg Ile 
                245                 250                 255     

Val Ala Gly Thr Gly Thr Ile Asp Arg Asp Gly Asn Val Gly Asp Ile 
            260                 265                 270         

Gly Gly Ile Asp Lys Lys Val Val Ala Ser Ala Arg Ala Gly Ala Ala 
        275                 280                 285             

Ile Phe Phe Ala Pro Asp Asn Pro Val Ser Glu Glu Glu Gln Lys Ala 
    290                 295                 300                 

His Pro Asp Ala Lys Asn Asn Tyr Gln Thr Ala Leu Glu Ala Ala Lys 
305                 310                 315                 320 

Thr Ile Lys Thr Asp Met Lys Ile Val Pro Val Lys Thr Leu Gln Asp 
                325                 330                 335     

Ala Ile Asp Tyr Leu Lys Asn Asn Pro 
            340                 345 

<210>   4099
<211>   486
<212>   DNA

<213>   Streptococcus pneumoniae

<400>   4099
atgtcagata agattggctt attcacaggc tcatttgatc cgatgacaaa tgggcatctg   60
gatatcattg aacgggcgag cagacttttt gataagcttt atgtgggtat tttttttaat   120
ccccacaaac aaggatttct ccctcttgaa aatcgtaaac gggggttaga aaaggctgtg   180
aaacatttgg gaaatgttaa agtcgtgtct tctcatgata aattggtggt cgatgtcgca   240
aaaagactgg gggctacttg cctagtgcga ggtttgagaa atgcgtcgga tttgcaatat   300
gaagccagtt ttgattacta caatcatcag ctgtcttctg atatagagac tatttattta   360
catagtcgac ctgaacatct ctatatcagt tcatcaggcg ttagagagct tttgaagttt   420
ggtcaggata ttgcctgcta tgttcccgag agtattttgg aggaaataag aaatgaaaaa   480
aaagat                                                              486

<210>   4100
<211>   162
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphopantetheine adenylyltransferase (coaD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903825 (5.E-88)

<400>   4100
Met Ser Asp Lys Ile Gly Leu Phe Thr Gly Ser Phe Asp Pro Met Thr 
1               5                   10                  15      

Asn Gly His Leu Asp Ile Ile Glu Arg Ala Ser Arg Leu Phe Asp Lys 
            20                  25                  30          

Leu Tyr Val Gly Ile Phe Phe Asn Pro His Lys Gln Gly Phe Leu Pro 
        35                  40                  45              

Leu Glu Asn Arg Lys Arg Gly Leu Glu Lys Ala Val Lys His Leu Gly 
    50                  55                  60                  

Asn Val Lys Val Val Ser Ser His Asp Lys Leu Val Val Asp Val Ala 
65                  70                  75                  80  

Lys Arg Leu Gly Ala Thr Cys Leu Val Arg Gly Leu Arg Asn Ala Ser 
                85                  90                  95      

Asp Leu Gln Tyr Glu Ala Ser Phe Asp Tyr Tyr Asn His Gln Leu Ser 
            100                 105                 110         

Ser Asp Ile Glu Thr Ile Tyr Leu His Ser Arg Pro Glu His Leu Tyr 
        115                 120                 125             

Ile Ser Ser Ser Gly Val Arg Glu Leu Leu Lys Phe Gly Gln Asp Ile 
    130                 135                 140                 

Ala Cys Tyr Val Pro Glu Ser Ile Leu Glu Glu Ile Arg Asn Glu Lys 
145                 150                 155                 160 

Lys Asp 
        

<210>   4101
<211>   537
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4101
atgaaaatcg tatcaggaat ctatggggga cgtcccctca agacactaga aggcaagacg   60
acaagaccta cttcggataa ggttagggga gccattttta acatgattgg tccctacttt   120
gaagtgggac gagtcttgga cctttatgca ggtagtggtg gtttatctat cgaagcagta   180
tcgcgtggca tgtccagtgc tgttttggtg gagcgagacc gtaaggctca gaccatcgtg   240
gctgaaaata tccagatgac caaggaagtt ggaaaatttc aactcctcaa gatggatgca   300
gaaagggcat tggaacaggt atctggggaa tttgacctcg ttttcttaga ccctccctat   360
gccaaggaac aaatcgtagc agatattgaa aaaatggctg agagagagct tttttctgaa   420
gatgttatgg ttgtgtgcga gacggataaa gccgttgaac ttccagaaga aattgcctgt   480
ctgggtatct ggaaggaaaa gatttatgga attagtaagg tgacagtcta tgtcaga      537

<210>   4102
<211>   179
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   type II DNA modification methyltransferase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903826 (7.E-97)

<400>   4102
Met Lys Ile Val Ser Gly Ile Tyr Gly Gly Arg Pro Leu Lys Thr Leu 
1               5                   10                  15      

Glu Gly Lys Thr Thr Arg Pro Thr Ser Asp Lys Val Arg Gly Ala Ile 
            20                  25                  30          

Phe Asn Met Ile Gly Pro Tyr Phe Glu Val Gly Arg Val Leu Asp Leu 
        35                  40                  45              

Tyr Ala Gly Ser Gly Gly Leu Ser Ile Glu Ala Val Ser Arg Gly Met 
    50                  55                  60                  

Ser Ser Ala Val Leu Val Glu Arg Asp Arg Lys Ala Gln Thr Ile Val 
65                  70                  75                  80  

Ala Glu Asn Ile Gln Met Thr Lys Glu Val Gly Lys Phe Gln Leu Leu 
                85                  90                  95      

Lys Met Asp Ala Glu Arg Ala Leu Glu Gln Val Ser Gly Glu Phe Asp 
            100                 105                 110         

Leu Val Phe Leu Asp Pro Pro Tyr Ala Lys Glu Gln Ile Val Ala Asp 
        115                 120                 125             

Ile Glu Lys Met Ala Glu Arg Glu Leu Phe Ser Glu Asp Val Met Val 
    130                 135                 140                 

Val Cys Glu Thr Asp Lys Ala Val Glu Leu Pro Glu Glu Ile Ala Cys 
145                 150                 155                 160 

Leu Gly Ile Trp Lys Glu Lys Ile Tyr Gly Ile Ser Lys Val Thr Val 
                165                 170                 175     

Tyr Val Arg 
            

<210>   4103
<211>   990
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4103
atgaagaaaa gttttatcca tcaacaagaa gaaatttcct ttgtcaaaaa cacttttacc   60
cagtatttga aagataagct agaagttgtc gaagttcaag gtcctatctt gagtaaggtc   120
ggtgacggaa tgcaggacaa cctgtctggt gtggaaaatc cagtatcggt caaggttctc   180
caaatccctg atgctactta tgaagtggtg cactcacttg ctaaatggaa acgccacacc   240
ttggctcgtt ttggctttgg tgaaggagag ggtctctttg tccacatgaa agcccttcgt   300
ccagatgagg attccttgga tgcaacccac tctgtttatg ttgaccagtg ggactgggag   360
aaggttatcc caaatggtaa gcgtaacatc gtttatctaa aagaaacagt tgagaagatt   420
tataaggcta ttcgcctgac tgagctagct gttgaagccc gctatgacat cgagtctatc   480
ttgccaaaac aaattacctt tatccataca gaagaattgg tagaacgcta cccagacttg   540
acaccgaaag aacgtgaaaa tgcgatttgt aaagaatttg gagccgtctt tttgattggt   600
atcggtggcg agttgccaga tggtaaaccg cacgatggac gtgcaccaga ctatgatgac   660
tggacaagcg agtctgagaa tggctacaag ggtctaaatg gtgatattct tgtctggaat   720
gagtctttag gtggagcctt tgagttgtct tctatgggaa ttcgtgtaga tgaagaaact   780
cttagacgtc aggtggaaat tacaggtgat gaagaccgct tggaattgga atggcacaag   840
tctttgttga atggtctatt cccattgaca atcggtggag gaattggaca atctcgtatg   900
gccatgttcc tacttcgcaa gagacacatc ggagaagtgc aaacaagtgt ttggcctcaa   960
gaagtccgcg atacttacga aaatattttg                                    990

<210>   4104
<211>   330
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aspartate--ammonia ligase (asnA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903827 (0.E+01)

<400>   4104
Met Lys Lys Ser Phe Ile His Gln Gln Glu Glu Ile Ser Phe Val Lys 
1               5                   10                  15      

Asn Thr Phe Thr Gln Tyr Leu Lys Asp Lys Leu Glu Val Val Glu Val 
            20                  25                  30          

Gln Gly Pro Ile Leu Ser Lys Val Gly Asp Gly Met Gln Asp Asn Leu 
        35                  40                  45              

Ser Gly Val Glu Asn Pro Val Ser Val Lys Val Leu Gln Ile Pro Asp 
    50                  55                  60                  

Ala Thr Tyr Glu Val Val His Ser Leu Ala Lys Trp Lys Arg His Thr 
65                  70                  75                  80  

Leu Ala Arg Phe Gly Phe Gly Glu Gly Glu Gly Leu Phe Val His Met 
                85                  90                  95      


Lys Ala Leu Arg Pro Asp Glu Asp Ser Leu Asp Ala Thr His Ser Val 
            100                 105                 110         

Tyr Val Asp Gln Trp Asp Trp Glu Lys Val Ile Pro Asn Gly Lys Arg 
        115                 120                 125             

Asn Ile Val Tyr Leu Lys Glu Thr Val Glu Lys Ile Tyr Lys Ala Ile 
    130                 135                 140                 

Arg Leu Thr Glu Leu Ala Val Glu Ala Arg Tyr Asp Ile Glu Ser Ile 
145                 150                 155                 160 

Leu Pro Lys Gln Ile Thr Phe Ile His Thr Glu Glu Leu Val Glu Arg 
                165                 170                 175     

Tyr Pro Asp Leu Thr Pro Lys Glu Arg Glu Asn Ala Ile Cys Lys Glu 
            180                 185                 190         

Phe Gly Ala Val Phe Leu Ile Gly Ile Gly Gly Glu Leu Pro Asp Gly 
        195                 200                 205             

Lys Pro His Asp Gly Arg Ala Pro Asp Tyr Asp Asp Trp Thr Ser Glu 
    210                 215                 220                 

Ser Glu Asn Gly Tyr Lys Gly Leu Asn Gly Asp Ile Leu Val Trp Asn 
225                 230                 235                 240 

Glu Ser Leu Gly Gly Ala Phe Glu Leu Ser Ser Met Gly Ile Arg Val 
                245                 250                 255     

Asp Glu Glu Thr Leu Arg Arg Gln Val Glu Ile Thr Gly Asp Glu Asp 
            260                 265                 270         

Arg Leu Glu Leu Glu Trp His Lys Ser Leu Leu Asn Gly Leu Phe Pro 
        275                 280                 285             

Leu Thr Ile Gly Gly Gly Ile Gly Gln Ser Arg Met Ala Met Phe Leu 
    290                 295                 300                 

Leu Arg Lys Arg His Ile Gly Glu Val Gln Thr Ser Val Trp Pro Gln 
305                 310                 315                 320 

Glu Val Arg Asp Thr Tyr Glu Asn Ile Leu 
                325                 330 

<210>   4105
<211>   162
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4105
ttgttgatgg ataaaacttt tcttcataga caactcctca aaaatttaat aaacgtatta   60
tacacctatt tccaagaaaa gaaaagagaa aatttaaaaa aaatcagtgt cactcaaaac   120
actgatttca tagacctttt agtcattgcg accaaagata cg                      162

<210>   4106
<211>   54
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903828 (2.E-25)

<400>   4106
Met Leu Met Asp Lys Thr Phe Leu His Arg Gln Leu Leu Lys Asn Leu 
1               5                   10                  15      

Ile Asn Val Leu Tyr Thr Tyr Phe Gln Glu Lys Lys Arg Glu Asn Leu 
            20                  25                  30          

Lys Lys Ile Ser Val Thr Gln Asn Thr Asp Phe Ile Asp Leu Leu Val 
        35                  40                  45              

Ile Ala Thr Lys Asp Thr 
    50                  

<210>   4107
<211>   705
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4107
atgttcacag aaaaggagaa atggatgaat cacactatta tacatgaccg tgcaggtctc   60
aatcaatttt acgctaaggt ttatgccttt gttggtctgg gaatcggact atctgctttg   120
gtatcaggcc ttatgttgac ggtctttcag tctcagttgg tttacttgtt gatgcagggg   180
cgtctctggt tgaccattgc tacttttgcg gagttggctt tggttttcgt tgccagtagc   240
atggcttcaa gaaatagtcc agctgctctt ccagtatttt tactttactc cgttttaaac   300
ggctttaccc ttagttttgt ggtggctttc tatactccgg gtacagtttt atctgccttt   360
gtatcgagcg cccttctctt ctttgtcatg gcggcagttg gtatctttac caagaaagac   420
ttgagtggga ttggtcgagc aatgatggca gctctcattg gtttactgat tgctatggta   480
gtcaatattt tcttggctag tggcttcttt gattatatga ttagcgtagc catggttttg   540
gttttttcag ggttgattgc ttgggataac caaaagattc gcctcgccta tgaacaatca   600
caaggtcgtg tagcgacagg ctgggtggtg tcaatggctc tcagcatcta tcttgatttt   660
atcaatcttt tcctaagtat tctacgtatc tttggtcgca atgac                   705

<210>   4108
<211>   235
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903829 (e-127)

<400>   4108
Met Phe Thr Glu Lys Glu Lys Trp Met Asn His Thr Ile Ile His Asp 
1               5                   10                  15      

Arg Ala Gly Leu Asn Gln Phe Tyr Ala Lys Val Tyr Ala Phe Val Gly 
            20                  25                  30          

Leu Gly Ile Gly Leu Ser Ala Leu Val Ser Gly Leu Met Leu Thr Val 
        35                  40                  45              


Phe Gln Ser Gln Leu Val Tyr Leu Leu Met Gln Gly Arg Leu Trp Leu 
    50                  55                  60                  

Thr Ile Ala Thr Phe Ala Glu Leu Ala Leu Val Phe Val Ala Ser Ser 
65                  70                  75                  80  

Met Ala Ser Arg Asn Ser Pro Ala Ala Leu Pro Val Phe Leu Leu Tyr 
                85                  90                  95      

Ser Val Leu Asn Gly Phe Thr Leu Ser Phe Val Val Ala Phe Tyr Thr 
            100                 105                 110         

Pro Gly Thr Val Leu Ser Ala Phe Val Ser Ser Ala Leu Leu Phe Phe 
        115                 120                 125             

Val Met Ala Ala Val Gly Ile Phe Thr Lys Lys Asp Leu Ser Gly Ile 
    130                 135                 140                 

Gly Arg Ala Met Met Ala Ala Leu Ile Gly Leu Leu Ile Ala Met Val 
145                 150                 155                 160 

Val Asn Ile Phe Leu Ala Ser Gly Phe Phe Asp Tyr Met Ile Ser Val 
                165                 170                 175     

Ala Met Val Leu Val Phe Ser Gly Leu Ile Ala Trp Asp Asn Gln Lys 
            180                 185                 190         

Ile Arg Leu Ala Tyr Glu Gln Ser Gln Gly Arg Val Ala Thr Gly Trp 
        195                 200                 205             

Val Val Ser Met Ala Leu Ser Ile Tyr Leu Asp Phe Ile Asn Leu Phe 
    210                 215                 220                 

Leu Ser Ile Leu Arg Ile Phe Gly Arg Asn Asp 
225                 230                 235 

<210>   4109
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4109
ttgtgttata atatttctat gactattata acctcaaaag ccaattctgt ggtaaaaaat   60
accaagaaat tacaccaaaa aaaataccgc aagtcagcct atttgattga aggctggcac   120
ttgtttgaag aagctgttca agctggagtg acgattgaga aaatctttac cctagaaaat   180
tatcgagatc agttagcaac tttttcgcaa actgtctggg tgtcagagga tattttgcta   240
gatttggcgg attctcagac tccacaggga attgtggccg tggttcaaaa agaagaagta   300
ggacaagctg atttgagtca gggcaagttc ttgtttttgg aagatgtgca agatcctggt   360
aatgtaggaa ctatcattcg aactgcggat gcagcaggtt ttacaggagt gattgtttca   420
gataagtcgg cagacatcta cagtctcaaa accctacgtt ccatgcaagg tagtcatttc   480
catctgccca tttaccggat gactagtcaa gcgcttcttg acgaaactaa aaaggtagct   540
atcccagtgt tagcaacaac cctatctaaa gattctgttg attacagaga actgccttct   600
atagaaaatt ttgtactagt tatgggaaat gagggtcaag gaattagtcc ccttatggct   660
gaaagtgcag accagttggt ccatattagc atgaaggggc aggccgagag tttgaatgtt   720
gcggttgcag ccggtatttt aatcttccat ttaagc                             756

<210>   4110
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SpoU rRNA Methylase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903830 (e-132)

<400>   4110
Met Cys Tyr Asn Ile Ser Met Thr Ile Ile Thr Ser Lys Ala Asn Ser 
1               5                   10                  15      

Val Val Lys Asn Thr Lys Lys Leu His Gln Lys Lys Tyr Arg Lys Ser 
            20                  25                  30          

Ala Tyr Leu Ile Glu Gly Trp His Leu Phe Glu Glu Ala Val Gln Ala 
        35                  40                  45              

Gly Val Thr Ile Glu Lys Ile Phe Thr Leu Glu Asn Tyr Arg Asp Gln 
    50                  55                  60                  

Leu Ala Thr Phe Ser Gln Thr Val Trp Val Ser Glu Asp Ile Leu Leu 
65                  70                  75                  80  

Asp Leu Ala Asp Ser Gln Thr Pro Gln Gly Ile Val Ala Val Val Gln 
                85                  90                  95      

Lys Glu Glu Val Gly Gln Ala Asp Leu Ser Gln Gly Lys Phe Leu Phe 
            100                 105                 110         

Leu Glu Asp Val Gln Asp Pro Gly Asn Val Gly Thr Ile Ile Arg Thr 
        115                 120                 125             

Ala Asp Ala Ala Gly Phe Thr Gly Val Ile Val Ser Asp Lys Ser Ala 
    130                 135                 140                 

Asp Ile Tyr Ser Leu Lys Thr Leu Arg Ser Met Gln Gly Ser His Phe 
145                 150                 155                 160 

His Leu Pro Ile Tyr Arg Met Thr Ser Gln Ala Leu Leu Asp Glu Thr 
                165                 170                 175     

Lys Lys Val Ala Ile Pro Val Leu Ala Thr Thr Leu Ser Lys Asp Ser 
            180                 185                 190         

Val Asp Tyr Arg Glu Leu Pro Ser Ile Glu Asn Phe Val Leu Val Met 
        195                 200                 205             

Gly Asn Glu Gly Gln Gly Ile Ser Pro Leu Met Ala Glu Ser Ala Asp 
    210                 215                 220                 

Gln Leu Val His Ile Ser Met Lys Gly Gln Ala Glu Ser Leu Asn Val 
225                 230                 235                 240 

Ala Val Ala Ala Gly Ile Leu Ile Phe His Leu Ser 
                245                 250         

<210>   4111
<211>   276
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4111
atgcaaaagg ttagaatgat tgcccaaggt agggtgcagg gagtcggctt tcgttggggt   60
gtttatagcc tggcccttga aatcggtggc atcacaggtc gggtatggaa taacgacgat   120
ggcacagtgg aaatcttagc ccaagcagac tcatcagcta ttatggcaaa atttatccaa   180
gaaatccgaa aaggaccgac acctttttca aaagtcagtt acttagatgt caaactgagc   240
aactttcctc cctaccctga ctttaaaatc gcaaat                             276

<210>   4112
<211>   92
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acylphosphatase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903831 (5.E-49)

<400>   4112
Met Gln Lys Val Arg Met Ile Ala Gln Gly Arg Val Gln Gly Val Gly 
1               5                   10                  15      

Phe Arg Trp Gly Val Tyr Ser Leu Ala Leu Glu Ile Gly Gly Ile Thr 
            20                  25                  30          

Gly Arg Val Trp Asn Asn Asp Asp Gly Thr Val Glu Ile Leu Ala Gln 
        35                  40                  45              

Ala Asp Ser Ser Ala Ile Met Ala Lys Phe Ile Gln Glu Ile Arg Lys 
    50                  55                  60                  

Gly Pro Thr Pro Phe Ser Lys Val Ser Tyr Leu Asp Val Lys Leu Ser 
65                  70                  75                  80  

Asn Phe Pro Pro Tyr Pro Asp Phe Lys Ile Ala Asn 
                85                  90          

<210>   4113
<211>   924
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4113
gtgaaatcta ttaaacgttt tgcactctcg gctatgggag tggctatgtt gcttgtcttg   60
actggctgtg tcaatgtcga taaaaccaca ggtcagccaa caggatttat ttggaatacg   120
atcggagcgc ctatggctga agccatcaag tacttcgcta ctgataaagg tctaggcttt   180
ggtgtcgcta tcattatcgt aaccattatc gtacgcttga ttatcttacc acttggtatc   240
taccaatcat ggaaggcaac gcttcactct gaaaagatga acgccctcaa gcacgtcctt   300
gagccacacc aaacgcgtct caaagaagcg actactcaag aagaaaaact cgaagcccaa   360
caagctctct ttgctgctca aaaagagcac ggtatcagca tgtttggcgg tgtaggatgt   420
ttccctatcc tccttcaaat gcctttcttc tctgctatct actttgctgc ccaacatact   480
gaaggggttg ctcaagcaag ctacctaggc attcctctag gttctccaag tatgattttg   540
gttgcctgtg ctggtgtcct ttactatctt caatcgctcc tttcacttca cggagtagaa   600
gatgaaatgc aaagagaaca aatcaagaaa atgatttaca tgagcccact catgatcgtc   660
gtcttctccc tcttctcacc agctagtgtc acactttact gggttgtcgg tggtttcatg   720
atgattctcc aacagtttat cgtcaactat atcgttcgtc caaaacttcg caaaaaagtc   780
cgtgaagaac tagccaagaa cccaccaaaa gcaagtgctt tctctaaacc aagtggacga   840
aaagacgtta cccctgaaca accaactgct atcacaagca agaaaaaaca caaaaatcgc   900
aacgctggaa aacaacgttc gaga                                          924

<210>   4114
<211>   308
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   stage III sporulation protein J (spoIIIJ)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903832 (e-173)

<400>   4114
Met Lys Ser Ile Lys Arg Phe Ala Leu Ser Ala Met Gly Val Ala Met 
1               5                   10                  15      

Leu Leu Val Leu Thr Gly Cys Val Asn Val Asp Lys Thr Thr Gly Gln 
            20                  25                  30          

Pro Thr Gly Phe Ile Trp Asn Thr Ile Gly Ala Pro Met Ala Glu Ala 
        35                  40                  45              

Ile Lys Tyr Phe Ala Thr Asp Lys Gly Leu Gly Phe Gly Val Ala Ile 
    50                  55                  60                  

Ile Ile Val Thr Ile Ile Val Arg Leu Ile Ile Leu Pro Leu Gly Ile 
65                  70                  75                  80  

Tyr Gln Ser Trp Lys Ala Thr Leu His Ser Glu Lys Met Asn Ala Leu 
                85                  90                  95      

Lys His Val Leu Glu Pro His Gln Thr Arg Leu Lys Glu Ala Thr Thr 
            100                 105                 110         

Gln Glu Glu Lys Leu Glu Ala Gln Gln Ala Leu Phe Ala Ala Gln Lys 
        115                 120                 125             

Glu His Gly Ile Ser Met Phe Gly Gly Val Gly Cys Phe Pro Ile Leu 
    130                 135                 140                 

Leu Gln Met Pro Phe Phe Ser Ala Ile Tyr Phe Ala Ala Gln His Thr 
145                 150                 155                 160 

Glu Gly Val Ala Gln Ala Ser Tyr Leu Gly Ile Pro Leu Gly Ser Pro 
                165                 170                 175     

Ser Met Ile Leu Val Ala Cys Ala Gly Val Leu Tyr Tyr Leu Gln Ser 
            180                 185                 190         

Leu Leu Ser Leu His Gly Val Glu Asp Glu Met Gln Arg Glu Gln Ile 
        195                 200                 205             

Lys Lys Met Ile Tyr Met Ser Pro Leu Met Ile Val Val Phe Ser Leu 
    210                 215                 220                 

Phe Ser Pro Ala Ser Val Thr Leu Tyr Trp Val Val Gly Gly Phe Met 
225                 230                 235                 240 

Met Ile Leu Gln Gln Phe Ile Val Asn Tyr Ile Val Arg Pro Lys Leu 
                245                 250                 255     

Arg Lys Lys Val Arg Glu Glu Leu Ala Lys Asn Pro Pro Lys Ala Ser 
            260                 265                 270         

Ala Phe Ser Lys Pro Ser Gly Arg Lys Asp Val Thr Pro Glu Gln Pro 
        275                 280                 285             

Thr Ala Ile Thr Ser Lys Lys Lys His Lys Asn Arg Asn Ala Gly Lys 
    290                 295                 300                 

Gln Arg Ser Arg 
305             

<210>   4115
<211>   792
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4115
atgtctgaag aaacaattga ttatggacaa gtgacaggaa tggtgcattc gacagaaagc   60
tttgggtcag tagatgggcc tggtattcgc tttattgtct ttttgcaggg ctgtcacatg   120
cgttgccagt attgccacaa cccagacact tgggctatgg agtccaataa gtcacgtgaa   180
cggacggtag atgatgtctt gacagaggcc ttgcgctacc gtggtttctg gggaaataag   240
ggtgggatta cagtcagtgg aggagaagct ctcttgcaga ttgatttcct gattgctctc   300
ttcaccaagg ctaaggaaca aggaatccac tgtaccttgg acacctgtgc tcttcctttc   360
cgtaataaac cacgttacct tgagaagttt gacaaactca tggctgtcac tgacttggtt   420
cttttggata tcaaggaaat caacgaagaa cagcacaaga ttgtcactag ccaaaccaat   480
aaaaatatct tggcttgtgc ccagtatcta tcagatattg gaaaacctgt ctggattcgc   540
cacgtgctag ttccaggatt gacagacaga gatgatgact tgattgaact tggtaagttc   600
gtcaagaccc tcaaaaatgt tgataagttt gaaattctac cttatcacac catgggtgag   660
ttcaagtggc gtgaacttgg aattccatat tccctcgaag gagtcaaacc accaacagca   720
gatcgcgtca agaacgctaa acaactcatg gataccgaaa gttatcaaga ttatatgaaa   780
cgtgtacatg ga                                                       792

<210>   4116
<211>   264
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyruvate formate-lyase-activating enzyme (pflA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903833 (e-157)

<400>   4116
Met Ser Glu Glu Thr Ile Asp Tyr Gly Gln Val Thr Gly Met Val His 
1               5                   10                  15      

Ser Thr Glu Ser Phe Gly Ser Val Asp Gly Pro Gly Ile Arg Phe Ile 
            20                  25                  30          

Val Phe Leu Gln Gly Cys His Met Arg Cys Gln Tyr Cys His Asn Pro 
        35                  40                  45              

Asp Thr Trp Ala Met Glu Ser Asn Lys Ser Arg Glu Arg Thr Val Asp 
    50                  55                  60                  

Asp Val Leu Thr Glu Ala Leu Arg Tyr Arg Gly Phe Trp Gly Asn Lys 
65                  70                  75                  80  

Gly Gly Ile Thr Val Ser Gly Gly Glu Ala Leu Leu Gln Ile Asp Phe 
                85                  90                  95      

Leu Ile Ala Leu Phe Thr Lys Ala Lys Glu Gln Gly Ile His Cys Thr 
            100                 105                 110         

Leu Asp Thr Cys Ala Leu Pro Phe Arg Asn Lys Pro Arg Tyr Leu Glu 
        115                 120                 125             

Lys Phe Asp Lys Leu Met Ala Val Thr Asp Leu Val Leu Leu Asp Ile 
    130                 135                 140                 

Lys Glu Ile Asn Glu Glu Gln His Lys Ile Val Thr Ser Gln Thr Asn 
145                 150                 155                 160 

Lys Asn Ile Leu Ala Cys Ala Gln Tyr Leu Ser Asp Ile Gly Lys Pro 
                165                 170                 175     

Val Trp Ile Arg His Val Leu Val Pro Gly Leu Thr Asp Arg Asp Asp 
            180                 185                 190         

Asp Leu Ile Glu Leu Gly Lys Phe Val Lys Thr Leu Lys Asn Val Asp 
        195                 200                 205             

Lys Phe Glu Ile Leu Pro Tyr His Thr Met Gly Glu Phe Lys Trp Arg 
    210                 215                 220                 

Glu Leu Gly Ile Pro Tyr Ser Leu Glu Gly Val Lys Pro Pro Thr Ala 
225                 230                 235                 240 

Asp Arg Val Lys Asn Ala Lys Gln Leu Met Asp Thr Glu Ser Tyr Gln 
                245                 250                 255     

Asp Tyr Met Lys Arg Val His Gly 
            260                 

<210>   4117
<211>   102
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4117
ttgaaggaaa aacaagattt ttgcctattt tttagaaagc aatctgtttt tcaatttcat   60
tttcaatcta ttatcagatt attcttcaaa atcgaagcca ta                      102

<210>   4118
<211>   34
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4118
Met Lys Glu Lys Gln Asp Phe Cys Leu Phe Phe Arg Lys Gln Ser Val 
1               5                   10                  15      

Phe Gln Phe His Phe Gln Ser Ile Ile Arg Leu Phe Phe Lys Ile Glu 
            20                  25                  30          

Ala Ile 
        

<210>   4119
<211>   1248
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4119
atgaaaacac catttatcaa tagagaagag ttagaagcga ttgttgccga gttcccgact   60
ccctttcact tgtatgatga gaaggggatt cgtgagaagg caagagccgt caaccaagct   120
ttttcgtgga acaagggctt taaggaatat tttgcagtta aggctactcc aactccagct   180
attttgaaaa ttctccaaga agaaggttgt ggtgtggact gctctagtta tgtagagctt   240
ttgatgagcc ataaactgga ctttctgggt tctgagatta tgttctcttc caacaacacg   300
ccagacaagg aatacgccta tgcacgtgaa ttgggtgcga ccattaactt ggatgccttt   360
gaagatattg aacatctgga gagagtagca ggcattccag aaatcatctc ttgtcgttat   420
aatcctggag gcgtttttga actggggaca gacattatgg acaatcctgg ggaggctaag   480
tttggcatga ccaaggacca gctctttgaa gcctttgcta tcttgaagga aaaaggagcc   540
aagacttttg ggattcactc cttcctagcg tccaataccg tgacccatct ctattatcca   600
gagttggctc gtcagctctt tgaactggct gttgaaatca aggaaaagtt gggcatttcg   660
ctagacttta tcaatctttc tggcggtatt ggtgttaatt atcatccaga ccaggagccg   720
aacgatatcg ccttgattgg tgagggagtt cgtaaggtgt atgaagaggt tcttacgtca   780
gcaggtcttg gtcaggtcaa gattttcacc gaattgggtc gttttatgct ggcacctcac   840
ggtgctctag tcacaagagt cactcataag aaggaaacct accgtaccta tctaggtgtg   900
gatgcctcag cagtcaacct catgcgtcca gctatgtacg gagcttacca tcatattagc   960
aacgtgaccc atccagatgg accagctgaa gtggtagatg tggtcggttc actctgtgaa   1020
aacaatgata aatttgcagt taatcgcgaa ctgcctcata cagaaatcgg tgatttgctg   1080
gtcattcatg atacaggtgc ccacggattt tcaatgggct accagtataa tgccaaatta   1140
cgttctgcgg aaatcctcta taccgaagaa ggtaaagccc gtcaaatccg ccgtgcagag   1200
cgccctgagg actattttgc aaccttatat ggcttcgatt ttgaagaa                1248

<210>   4120
<211>   416
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   diaminopimelate decarboxylase (lysA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903834 (0.E+01)

<400>   4120
Met Lys Thr Pro Phe Ile Asn Arg Glu Glu Leu Glu Ala Ile Val Ala 
1               5                   10                  15      

Glu Phe Pro Thr Pro Phe His Leu Tyr Asp Glu Lys Gly Ile Arg Glu 
            20                  25                  30          

Lys Ala Arg Ala Val Asn Gln Ala Phe Ser Trp Asn Lys Gly Phe Lys 
        35                  40                  45              

Glu Tyr Phe Ala Val Lys Ala Thr Pro Thr Pro Ala Ile Leu Lys Ile 
    50                  55                  60                  

Leu Gln Glu Glu Gly Cys Gly Val Asp Cys Ser Ser Tyr Val Glu Leu 
65                  70                  75                  80  

Leu Met Ser His Lys Leu Asp Phe Leu Gly Ser Glu Ile Met Phe Ser 
                85                  90                  95      

Ser Asn Asn Thr Pro Asp Lys Glu Tyr Ala Tyr Ala Arg Glu Leu Gly 
            100                 105                 110         

Ala Thr Ile Asn Leu Asp Ala Phe Glu Asp Ile Glu His Leu Glu Arg 
        115                 120                 125             

Val Ala Gly Ile Pro Glu Ile Ile Ser Cys Arg Tyr Asn Pro Gly Gly 
    130                 135                 140                 

Val Phe Glu Leu Gly Thr Asp Ile Met Asp Asn Pro Gly Glu Ala Lys 
145                 150                 155                 160 

Phe Gly Met Thr Lys Asp Gln Leu Phe Glu Ala Phe Ala Ile Leu Lys 
                165                 170                 175     

Glu Lys Gly Ala Lys Thr Phe Gly Ile His Ser Phe Leu Ala Ser Asn 
            180                 185                 190         

Thr Val Thr His Leu Tyr Tyr Pro Glu Leu Ala Arg Gln Leu Phe Glu 
        195                 200                 205             

Leu Ala Val Glu Ile Lys Glu Lys Leu Gly Ile Ser Leu Asp Phe Ile 
    210                 215                 220                 

Asn Leu Ser Gly Gly Ile Gly Val Asn Tyr His Pro Asp Gln Glu Pro 
225                 230                 235                 240 

Asn Asp Ile Ala Leu Ile Gly Glu Gly Val Arg Lys Val Tyr Glu Glu 
                245                 250                 255     

Val Leu Thr Ser Ala Gly Leu Gly Gln Val Lys Ile Phe Thr Glu Leu 
            260                 265                 270         

Gly Arg Phe Met Leu Ala Pro His Gly Ala Leu Val Thr Arg Val Thr 
        275                 280                 285             

His Lys Lys Glu Thr Tyr Arg Thr Tyr Leu Gly Val Asp Ala Ser Ala 
    290                 295                 300                 

Val Asn Leu Met Arg Pro Ala Met Tyr Gly Ala Tyr His His Ile Ser 
305                 310                 315                 320 

Asn Val Thr His Pro Asp Gly Pro Ala Glu Val Val Asp Val Val Gly 
                325                 330                 335     

Ser Leu Cys Glu Asn Asn Asp Lys Phe Ala Val Asn Arg Glu Leu Pro 
            340                 345                 350         

His Thr Glu Ile Gly Asp Leu Leu Val Ile His Asp Thr Gly Ala His 
        355                 360                 365             


Gly Phe Ser Met Gly Tyr Gln Tyr Asn Ala Lys Leu Arg Ser Ala Glu 
    370                 375                 380                 

Ile Leu Tyr Thr Glu Glu Gly Lys Ala Arg Gln Ile Arg Arg Ala Glu 
385                 390                 395                 400 

Arg Pro Glu Asp Tyr Phe Ala Thr Leu Tyr Gly Phe Asp Phe Glu Glu 
                405                 410                 415     


<210>   4121
<211>   825
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4121
atgaaattaa gaagaagtga tcggatggtt gtcatttcca actatttgat taataatcct   60
tataaactaa ctagtctcaa tacttttgct gaaaagtatg agtctgctaa atcatccatc   120
tcagaagata tcgtcattat caaacgcgcc tttgaggaaa ttgaaatcgg tcatatccag   180
acagtgactg gggctggcgg aggtgtcatc ttcacaccgt ctatttcgag tcaggatgct   240
aaggaaatgg ttgaagactt gcgtaccaag ttgtcagaaa gtgaccgtat cttgccaggt   300
ggttatatct atctgtctga tttgcttagc acaccagcca tcttgaaaaa tattggtcgt   360
attattgcca aaagctttat ggaccaaaaa attgacgcgg ttatgaccgt agcaactaag   420
ggtgtgccac ttgcaaatgc agttgccaat gtcctcaatg tctcttttgt cattgtgcgc   480
cgtgacctga aaattaccga aggttcaact gttagcgtca actatgtttc aggttcaagt   540
ggtgaccgta tcgagaaaat gttcctttca aaacgtagtc ttaaggcagg cagccgtgtc   600
ttgattgtgg atgacttctt gaaaggtggc ggaacggtca atggtatgat tagtctcttg   660
cgcgagttcg actcagaact ggcaggtgta gcggtctttg cggacaatgc ccaagaagaa   720
cgtgaaaagc agtttgacta caagtcactc ttgaaggtaa ccaatattga tgtcaagaac   780
caagccatcg atgttgaggt tggcaatatc tttgacgaag ataaa                   825

<210>   4122
<211>   275
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pur operon repressor (purR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903835 (e-150)

<400>   4122
Met Lys Leu Arg Arg Ser Asp Arg Met Val Val Ile Ser Asn Tyr Leu 
1               5                   10                  15      

Ile Asn Asn Pro Tyr Lys Leu Thr Ser Leu Asn Thr Phe Ala Glu Lys 
            20                  25                  30          

Tyr Glu Ser Ala Lys Ser Ser Ile Ser Glu Asp Ile Val Ile Ile Lys 
        35                  40                  45              

Arg Ala Phe Glu Glu Ile Glu Ile Gly His Ile Gln Thr Val Thr Gly 
    50                  55                  60                  

Ala Gly Gly Gly Val Ile Phe Thr Pro Ser Ile Ser Ser Gln Asp Ala 
65                  70                  75                  80  

Lys Glu Met Val Glu Asp Leu Arg Thr Lys Leu Ser Glu Ser Asp Arg 
                85                  90                  95      

Ile Leu Pro Gly Gly Tyr Ile Tyr Leu Ser Asp Leu Leu Ser Thr Pro 
            100                 105                 110         

Ala Ile Leu Lys Asn Ile Gly Arg Ile Ile Ala Lys Ser Phe Met Asp 
        115                 120                 125             

Gln Lys Ile Asp Ala Val Met Thr Val Ala Thr Lys Gly Val Pro Leu 
    130                 135                 140                 

Ala Asn Ala Val Ala Asn Val Leu Asn Val Ser Phe Val Ile Val Arg 
145                 150                 155                 160 

Arg Asp Leu Lys Ile Thr Glu Gly Ser Thr Val Ser Val Asn Tyr Val 
                165                 170                 175     

Ser Gly Ser Ser Gly Asp Arg Ile Glu Lys Met Phe Leu Ser Lys Arg 
            180                 185                 190         

Ser Leu Lys Ala Gly Ser Arg Val Leu Ile Val Asp Asp Phe Leu Lys 
        195                 200                 205             

Gly Gly Gly Thr Val Asn Gly Met Ile Ser Leu Leu Arg Glu Phe Asp 
    210                 215                 220                 

Ser Glu Leu Ala Gly Val Ala Val Phe Ala Asp Asn Ala Gln Glu Glu 
225                 230                 235                 240 

Arg Glu Lys Gln Phe Asp Tyr Lys Ser Leu Leu Lys Val Thr Asn Ile 
                245                 250                 255     

Asp Val Lys Asn Gln Ala Ile Asp Val Glu Val Gly Asn Ile Phe Asp 
            260                 265                 270         

Glu Asp Lys 
        275 

<210>   4123
<211>   939
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4123
atgaagatta gtcacatgaa aaaagatgag ttatttgaag gcttttacct aatcaaatca   60
gctgacctga ggcaaactcg agctgggaaa aactacctag cctttacctt ccaagatgat   120
agtggcgaga ttgatgggaa gctctgggat gcccaacctc ataacattga ggcctttacc   180
gcaggtaagg ttgtccacat gaaaggacgc cgagaagttt ataacaatac ccctcaagtc   240
aatcaaatta ctctccgcct gcctcaagct ggtgaaccca atgacccagc tgatttcaag   300
gtcaagtcac cagttgatgt caaggaaatt cgtgactaca tgtcgcaaat gattttcaaa   360
attgaaaatc ctgtctggca acggattgtc cgaaatctct acaccaagta tgataaggaa   420
ttctactcct atccagctgc caagaccaac caccatgcct ttgaaacggg cttggcctat   480
catacggcga ccatggtgcg tttggcagac gctattagcg aagtttatcc tcagctcaat   540
aagagcctgc tctatgcggg gattatgttg catgacttag ctaaggtcat cgagttgacg   600
gggccagacc agacagagta cacagtgcga ggtaatcttc ttggacatat cgctctcatt   660
gatagcgaaa ttaccaagac agttatggaa ctcggcatcg atgataccaa ggaagaagtc   720
gttttgcttc gtcatgtcat cctcagtcac cacggcttgc ttgagtatgg aagcccagtc   780
cgtccacgca ttatggaagc agagattatc catatgattg acaatctgga tgcaagcatg   840
atgatgatgt caacagctct tgctttggtg gataaaggag agatgaccaa taaaatcttc   900
gctatggata atcgttcctt ctataaacca gatttagat                          939

<210>   4124
<211>   313
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cmp-binding-factor 1 (cbf1)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903836 (e-179)

<400>   4124
Met Lys Ile Ser His Met Lys Lys Asp Glu Leu Phe Glu Gly Phe Tyr 
1               5                   10                  15      

Leu Ile Lys Ser Ala Asp Leu Arg Gln Thr Arg Ala Gly Lys Asn Tyr 
            20                  25                  30          

Leu Ala Phe Thr Phe Gln Asp Asp Ser Gly Glu Ile Asp Gly Lys Leu 
        35                  40                  45              

Trp Asp Ala Gln Pro His Asn Ile Glu Ala Phe Thr Ala Gly Lys Val 
    50                  55                  60                  

Val His Met Lys Gly Arg Arg Glu Val Tyr Asn Asn Thr Pro Gln Val 
65                  70                  75                  80  

Asn Gln Ile Thr Leu Arg Leu Pro Gln Ala Gly Glu Pro Asn Asp Pro 
                85                  90                  95      

Ala Asp Phe Lys Val Lys Ser Pro Val Asp Val Lys Glu Ile Arg Asp 
            100                 105                 110         

Tyr Met Ser Gln Met Ile Phe Lys Ile Glu Asn Pro Val Trp Gln Arg 
        115                 120                 125             

Ile Val Arg Asn Leu Tyr Thr Lys Tyr Asp Lys Glu Phe Tyr Ser Tyr 
    130                 135                 140                 

Pro Ala Ala Lys Thr Asn His His Ala Phe Glu Thr Gly Leu Ala Tyr 
145                 150                 155                 160 

His Thr Ala Thr Met Val Arg Leu Ala Asp Ala Ile Ser Glu Val Tyr 
                165                 170                 175     

Pro Gln Leu Asn Lys Ser Leu Leu Tyr Ala Gly Ile Met Leu His Asp 
            180                 185                 190         

Leu Ala Lys Val Ile Glu Leu Thr Gly Pro Asp Gln Thr Glu Tyr Thr 
        195                 200                 205             

Val Arg Gly Asn Leu Leu Gly His Ile Ala Leu Ile Asp Ser Glu Ile 
    210                 215                 220                 

Thr Lys Thr Val Met Glu Leu Gly Ile Asp Asp Thr Lys Glu Glu Val 
225                 230                 235                 240 

Val Leu Leu Arg His Val Ile Leu Ser His His Gly Leu Leu Glu Tyr 
                245                 250                 255     

Gly Ser Pro Val Arg Pro Arg Ile Met Glu Ala Glu Ile Ile His Met 
            260                 265                 270         

Ile Asp Asn Leu Asp Ala Ser Met Met Met Met Ser Thr Ala Leu Ala 
        275                 280                 285             

Leu Val Asp Lys Gly Glu Met Thr Asn Lys Ile Phe Ala Met Asp Asn 
    290                 295                 300                 

Arg Ser Phe Tyr Lys Pro Asp Leu Asp 
305                 310             

<210>   4125
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4125
atggaaagtt tacttattct attattaatt gccaatctag ctggtctctt tctgatttgg   60
caaaggcagg ataggcagga gaaacactta agtaagagct tggaggatca ggcagatcat   120
ttgtcagacc agttggatta ccgctttgac caagccagac aagccagcca gttagaccaa   180
aaagatttgg aagtggttgt cagcgaccgt ttgcaagaag tgcggattga attgcaccaa   240
ggtctgaccc aagtccgtca agaaatgaca gataatctcc tccaaactag agacaagaca   300
gaccaacgtc tccaagcctt gcaggaatca aatgagcaac gtttggaaca aatgcgccag   360
acggtcgagg aaaaactaga aaagaccttg cagacacgct tacaggcttc ctttgagaca   420
gtttctaaac aactggagtc tgtcaatcgt ggccttggag aaatgcagac agttgcccgt   480
gatgtcggag ctcttaacaa ggttctctct ggaaccaaga cgcgagggat tctgggagaa   540
ttgcaactgg ggcaaattat tgaagacatc atgacacctg cccagtacga acgagaatac   600
gcaacggttg aaaactctag tgaacgagtg gagtatgcca tcaagttacc cggacaaggc   660
gaccaagaat acgtctatct gccaattgac tctaagtttc cactggcaga ttattaccgc   720
ttggaagaag cctatgagac aggtgacaag gatgagattg aacgctgtcg taagtcactc   780
ctagcaagcg tcaagcgctt tgctagggat attaggaaca agtacatagc accacctcgg   840
acgaccaatt ttggagtttt gtttgttccg acagaaggtc tctactcaga aatcgtccgc   900
aatccggtct tctttgatga tttgagacgg gaagaacaga ttattgttgc aggaccaagt   960
accctatcag cccttcttaa ctccctatca gttggtttca agacccttaa tatccaaaag   1020
agtgccgacc atatcagcaa gactcttgcc agtgtcaaga ccgagtttgg caagtttggt   1080
ggtattctgg tcaaggcaca aaaacatctc caacatgcct ctggcaatat tgatgaatta   1140
ttaaaccgtc gtaccatagc tatcgagcgg acgctccgtc acattgagtt gtcagaaggt   1200
gagcctgcgc ttgatctact ccattttcaa gaaaatgagg aagaatatga agat         1254

<210>   4126
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence-induced protein Ccs50 (ccs50)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903837 (0.E+01)

<400>   4126
Met Glu Ser Leu Leu Ile Leu Leu Leu Ile Ala Asn Leu Ala Gly Leu 
1               5                   10                  15      

Phe Leu Ile Trp Gln Arg Gln Asp Arg Gln Glu Lys His Leu Ser Lys 
            20                  25                  30          

Ser Leu Glu Asp Gln Ala Asp His Leu Ser Asp Gln Leu Asp Tyr Arg 
        35                  40                  45              

Phe Asp Gln Ala Arg Gln Ala Ser Gln Leu Asp Gln Lys Asp Leu Glu 
    50                  55                  60                  

Val Val Val Ser Asp Arg Leu Gln Glu Val Arg Ile Glu Leu His Gln 
65                  70                  75                  80  

Gly Leu Thr Gln Val Arg Gln Glu Met Thr Asp Asn Leu Leu Gln Thr 
                85                  90                  95      

Arg Asp Lys Thr Asp Gln Arg Leu Gln Ala Leu Gln Glu Ser Asn Glu 
            100                 105                 110         

Gln Arg Leu Glu Gln Met Arg Gln Thr Val Glu Glu Lys Leu Glu Lys 
        115                 120                 125             

Thr Leu Gln Thr Arg Leu Gln Ala Ser Phe Glu Thr Val Ser Lys Gln 
    130                 135                 140                 

Leu Glu Ser Val Asn Arg Gly Leu Gly Glu Met Gln Thr Val Ala Arg 
145                 150                 155                 160 

Asp Val Gly Ala Leu Asn Lys Val Leu Ser Gly Thr Lys Thr Arg Gly 
                165                 170                 175     

Ile Leu Gly Glu Leu Gln Leu Gly Gln Ile Ile Glu Asp Ile Met Thr 
            180                 185                 190         

Pro Ala Gln Tyr Glu Arg Glu Tyr Ala Thr Val Glu Asn Ser Ser Glu 
        195                 200                 205             

Arg Val Glu Tyr Ala Ile Lys Leu Pro Gly Gln Gly Asp Gln Glu Tyr 
    210                 215                 220                 

Val Tyr Leu Pro Ile Asp Ser Lys Phe Pro Leu Ala Asp Tyr Tyr Arg 
225                 230                 235                 240 

Leu Glu Glu Ala Tyr Glu Thr Gly Asp Lys Asp Glu Ile Glu Arg Cys 
                245                 250                 255     

Arg Lys Ser Leu Leu Ala Ser Val Lys Arg Phe Ala Arg Asp Ile Arg 
            260                 265                 270         

Asn Lys Tyr Ile Ala Pro Pro Arg Thr Thr Asn Phe Gly Val Leu Phe 
        275                 280                 285             

Val Pro Thr Glu Gly Leu Tyr Ser Glu Ile Val Arg Asn Pro Val Phe 
    290                 295                 300                 

Phe Asp Asp Leu Arg Arg Glu Glu Gln Ile Ile Val Ala Gly Pro Ser 
305                 310                 315                 320 

Thr Leu Ser Ala Leu Leu Asn Ser Leu Ser Val Gly Phe Lys Thr Leu 
                325                 330                 335     

Asn Ile Gln Lys Ser Ala Asp His Ile Ser Lys Thr Leu Ala Ser Val 
            340                 345                 350         

Lys Thr Glu Phe Gly Lys Phe Gly Gly Ile Leu Val Lys Ala Gln Lys 
        355                 360                 365             

His Leu Gln His Ala Ser Gly Asn Ile Asp Glu Leu Leu Asn Arg Arg 
    370                 375                 380                 

Thr Ile Ala Ile Glu Arg Thr Leu Arg His Ile Glu Leu Ser Glu Gly 
385                 390                 395                 400 

Glu Pro Ala Leu Asp Leu Leu His Phe Gln Glu Asn Glu Glu Glu Tyr 
                405                 410                 415     

Glu Asp 
        

<210>   4127
<211>   681
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4127
atgtctttaa gggagaagtc aatgagcgag tacaaactct cagaaaacaa ctggactagg   60
gttgcagttt ttgcaggcgg aaaccgcggt cattatcgga cagattttga tgcttttgtt   120
ggggtggatc gaggctcgct ctgggtcttg gaagaagact tacctcttgc tctagcagtc   180
ggagattttg attctgtgac ggaagaagag cgacaggtga ttcaaaaagg tgcccagtat   240
tttgtccaag cacgaccaga aaaggatgat acagatctgg aattggctct cttaaccatc   300
tttgaacaaa atcctcaggc tcaggtcact attttcggtg ccttgggtgg ccgtattgac   360
catatgttgg ccaatgtctt tctgcctagc aatcctaagt tggcacccta tatgcatcaa   420
atagaaattg aggatgggca aaacttgatt acttattgtc cagaaggaat cagtcagcta   480
gaacctcgtt cagactacga ctatctagcc tttatgccag ttcgggatag ccagctgact   540
attcttggag ccaagtatga gttgacagag gaaaattttt tctttaaaaa agtgtacgct   600
tctaacgaat atatagatag ggaagtgtcg gtaacttgcc cagatggtta tgtggtcgta   660
ctgcatagca aggacaggag g                                             681

<210>   4128
<211>   227
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903838 (e-127)

<400>   4128
Met Ser Leu Arg Glu Lys Ser Met Ser Glu Tyr Lys Leu Ser Glu Asn 
1               5                   10                  15      

Asn Trp Thr Arg Val Ala Val Phe Ala Gly Gly Asn Arg Gly His Tyr 
            20                  25                  30          

Arg Thr Asp Phe Asp Ala Phe Val Gly Val Asp Arg Gly Ser Leu Trp 
        35                  40                  45              

Val Leu Glu Glu Asp Leu Pro Leu Ala Leu Ala Val Gly Asp Phe Asp 
    50                  55                  60                  

Ser Val Thr Glu Glu Glu Arg Gln Val Ile Gln Lys Gly Ala Gln Tyr 
65                  70                  75                  80  

Phe Val Gln Ala Arg Pro Glu Lys Asp Asp Thr Asp Leu Glu Leu Ala 
                85                  90                  95      

Leu Leu Thr Ile Phe Glu Gln Asn Pro Gln Ala Gln Val Thr Ile Phe 
            100                 105                 110         

Gly Ala Leu Gly Gly Arg Ile Asp His Met Leu Ala Asn Val Phe Leu 
        115                 120                 125             

Pro Ser Asn Pro Lys Leu Ala Pro Tyr Met His Gln Ile Glu Ile Glu 
    130                 135                 140                 

Asp Gly Gln Asn Leu Ile Thr Tyr Cys Pro Glu Gly Ile Ser Gln Leu 
145                 150                 155                 160 

Glu Pro Arg Ser Asp Tyr Asp Tyr Leu Ala Phe Met Pro Val Arg Asp 
                165                 170                 175     

Ser Gln Leu Thr Ile Leu Gly Ala Lys Tyr Glu Leu Thr Glu Glu Asn 
            180                 185                 190         

Phe Phe Phe Lys Lys Val Tyr Ala Ser Asn Glu Tyr Ile Asp Arg Glu 
        195                 200                 205             

Val Ser Val Thr Cys Pro Asp Gly Tyr Val Val Val Leu His Ser Lys 
    210                 215                 220                 

Asp Arg Arg 
225         

<210>   4129
<211>   654
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4129
atgtctcaat acaagattgc tccgtcaatt ctggcagcag attatgccaa ctttgaacgt   60
gaaatcaaac gtctagaagc aactggggca gaatatgccc atatcgatat catggacagt   120
cattttgtac cgcaaatcag ttttggtgca ggtgtggtcg agagccttcg tcctcatagt   180
aagatggttt tcgattgcca cttgatggtg tcaaaccctg agcatcatct ggaagatttt   240
gcgcgtgcag gtgcagacat catcagtatc catgtagaag caacgcctca tattcatggc   300
gccctccaaa aaattcgttc actcggagtt aagccttcag tcgttatcaa tcctggcaca   360
tcagttgaag ccatcaagca cgtccttcat ctagttgacc aagttttagt catgacggtt   420
aatccaggtt ttggtgggca agcctttctg ccagaaacca tggataaggt ccgtgagttg   480
gttgctcttc gtgaggaaaa aggtttgaac tttgaaatcg aagtggatgg tgggattgat   540
gaccaaacta ttgctcaagc caaagaagcc ggtgcgactg tttttgtagc aggttcctat   600
gtctttaagg gagaagtcaa tgagcgagta caaactctca gaaaacaact ggac         654

<210>   4130
<211>   218
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribulose-phosphate 3-epimerase (rpe)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903839 (e-122)

<400>   4130
Met Ser Gln Tyr Lys Ile Ala Pro Ser Ile Leu Ala Ala Asp Tyr Ala 
1               5                   10                  15      

Asn Phe Glu Arg Glu Ile Lys Arg Leu Glu Ala Thr Gly Ala Glu Tyr 
            20                  25                  30          

Ala His Ile Asp Ile Met Asp Ser His Phe Val Pro Gln Ile Ser Phe 
        35                  40                  45              

Gly Ala Gly Val Val Glu Ser Leu Arg Pro His Ser Lys Met Val Phe 
    50                  55                  60                  

Asp Cys His Leu Met Val Ser Asn Pro Glu His His Leu Glu Asp Phe 

65                  70                  75                  80  

Ala Arg Ala Gly Ala Asp Ile Ile Ser Ile His Val Glu Ala Thr Pro 
                85                  90                  95      

His Ile His Gly Ala Leu Gln Lys Ile Arg Ser Leu Gly Val Lys Pro 
            100                 105                 110         

Ser Val Val Ile Asn Pro Gly Thr Ser Val Glu Ala Ile Lys His Val 
        115                 120                 125             

Leu His Leu Val Asp Gln Val Leu Val Met Thr Val Asn Pro Gly Phe 
    130                 135                 140                 

Gly Gly Gln Ala Phe Leu Pro Glu Thr Met Asp Lys Val Arg Glu Leu 
145                 150                 155                 160 

Val Ala Leu Arg Glu Glu Lys Gly Leu Asn Phe Glu Ile Glu Val Asp 
                165                 170                 175     

Gly Gly Ile Asp Asp Gln Thr Ile Ala Gln Ala Lys Glu Ala Gly Ala 
            180                 185                 190         

Thr Val Phe Val Ala Gly Ser Tyr Val Phe Lys Gly Glu Val Asn Glu 
        195                 200                 205             

Arg Val Gln Thr Leu Arg Lys Gln Leu Asp 
    210                 215             

<210>   4131
<211>   876
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4131
atgcagggac aaatcattaa agccttggca ggtttctact atgtggagag tgatggccag   60
gtttatcaaa cacgcgcgcg tgggaatttc cgtaaaaaag gccatacccc ttatgttggg   120
gactgggtag atttctctgc cgaggaaaat tcagaaggct atatcctcaa aattcacgaa   180
cggaaaaaca gtctggttcg tccgcctatt gtcaatatcg atcaagctgt agtaatcatg   240
tccgtcaagg aacctgattt taacagcaat ttgctggatc gtttcttggt tcttttggag   300
cacaagggca tccatcccat tgtctatatt tccaaaatgg atttgttgga agatagggga   360
gaactggatt tttaccagca gacctatggt gacatcggct atgactttgt gaccagtaaa   420
gaggaactcc tgtctttgtt aacaggcaag gttacggtct ttatggggca gacaggtgtt   480
gggaagtcaa ctcttctcaa taaaatcgca ccagacctca atcttgaaac gggagaaatt   540
tcagacagtc taggtcgcgg tcgccatacc actcgagctg ttagttttta caatctcaac   600
gggggtaaaa tcgcagatac accaggattt tcatccttgg actatgaagt atcaagggct   660
gaagacctca atcaggcttt cccagagatt gctactgtta gccgagattg taagttccgt   720
acttgtaccc atacccatga gccgtcttgt gccgtcaaac cagctgttga agagggtgtt   780
attgcaacct tccgttttga caattacctg caattcctta gtgaaattga aaatcgtaga   840
gaaacctata aaaaagtcag caaaaaaatt ccaaaa                             876

<210>   4132
<211>   292
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903840 (e-170)

<400>   4132
Met Gln Gly Gln Ile Ile Lys Ala Leu Ala Gly Phe Tyr Tyr Val Glu 
1               5                   10                  15      

Ser Asp Gly Gln Val Tyr Gln Thr Arg Ala Arg Gly Asn Phe Arg Lys 
            20                  25                  30          

Lys Gly His Thr Pro Tyr Val Gly Asp Trp Val Asp Phe Ser Ala Glu 
        35                  40                  45              

Glu Asn Ser Glu Gly Tyr Ile Leu Lys Ile His Glu Arg Lys Asn Ser 
    50                  55                  60                  

Leu Val Arg Pro Pro Ile Val Asn Ile Asp Gln Ala Val Val Ile Met 
65                  70                  75                  80  

Ser Val Lys Glu Pro Asp Phe Asn Ser Asn Leu Leu Asp Arg Phe Leu 
                85                  90                  95      

Val Leu Leu Glu His Lys Gly Ile His Pro Ile Val Tyr Ile Ser Lys 
            100                 105                 110         

Met Asp Leu Leu Glu Asp Arg Gly Glu Leu Asp Phe Tyr Gln Gln Thr 
        115                 120                 125             

Tyr Gly Asp Ile Gly Tyr Asp Phe Val Thr Ser Lys Glu Glu Leu Leu 
    130                 135                 140                 

Ser Leu Leu Thr Gly Lys Val Thr Val Phe Met Gly Gln Thr Gly Val 
145                 150                 155                 160 

Gly Lys Ser Thr Leu Leu Asn Lys Ile Ala Pro Asp Leu Asn Leu Glu 
                165                 170                 175     

Thr Gly Glu Ile Ser Asp Ser Leu Gly Arg Gly Arg His Thr Thr Arg 
            180                 185                 190         

Ala Val Ser Phe Tyr Asn Leu Asn Gly Gly Lys Ile Ala Asp Thr Pro 
        195                 200                 205             

Gly Phe Ser Ser Leu Asp Tyr Glu Val Ser Arg Ala Glu Asp Leu Asn 
    210                 215                 220                 

Gln Ala Phe Pro Glu Ile Ala Thr Val Ser Arg Asp Cys Lys Phe Arg 
225                 230                 235                 240 

Thr Cys Thr His Thr His Glu Pro Ser Cys Ala Val Lys Pro Ala Val 
                245                 250                 255     

Glu Glu Gly Val Ile Ala Thr Phe Arg Phe Asp Asn Tyr Leu Gln Phe 
            260                 265                 270         

Leu Ser Glu Ile Glu Asn Arg Arg Glu Thr Tyr Lys Lys Val Ser Lys 
        275                 280                 285             

Lys Ile Pro Lys 
    290         

<210>   4133
<211>   870
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4133
atgagaattg cagattatag cgtgaccaag gcagtgctgg agcgtcacgg ttttaccttt   60
aaaaagtcct ttgggcaaaa ttttttgacg gataccaata tccttcaaaa aattgtggat   120
acggctgaaa ttgatgatca ggtcaatgtc atcgaaatcg ggccaggtat tggtgccttg   180
acagaatttt tggctgagcg tgcagcccaa gtcatggctt ttgagattga ccaccgtttg   240
gtgccaattt tggcagatac cctgcgtgat tttgataatg tgaccgtagt taacgaagat   300
attctcaagg ttgatttggc gcaacatatc cagaatttta aaaatcctga cctgccaatc   360
aaggtagtgg ctaatttgcc ttactacatc acgacgccta ttctcatgca cttgattgag   420
agtggcattc ctttttgtga gtttgtggtc atgatgcaga aagaagtagc ggaccgcatt   480
tcagcccagc ctaacaccaa ggcttacggt agcttgtcta tcgccgtgca gtattacatg   540
acagccaagg ttgcctttat cgtgcctcgt acggtctttg tgccagcgcc aaatgtggat   600
tcagccatct tgaaaatggt gcgtcgtcca gagccagccg tagcagtaga agatgagaac   660
tttttcttta aggtttccaa ggctagtttt acccatcgcc gcaagacctt gtggaataac   720
ttgacaggtt actttggtaa gactgaagag gtcaaggaca agctgaccaa ggctttggac   780
caggcaggct tgtcaccaag tgtgcgtggg gaagctctca gcttggcaga atttgccggt   840
ctagcagacg cacttaaagg gcaaggactc                                    870

<210>   4134
<211>   290
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dimethyladenosine transferase (ksgA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903841 (e-155)

<400>   4134
Met Arg Ile Ala Asp Tyr Ser Val Thr Lys Ala Val Leu Glu Arg His 
1               5                   10                  15      

Gly Phe Thr Phe Lys Lys Ser Phe Gly Gln Asn Phe Leu Thr Asp Thr 
            20                  25                  30          

Asn Ile Leu Gln Lys Ile Val Asp Thr Ala Glu Ile Asp Asp Gln Val 
        35                  40                  45              

Asn Val Ile Glu Ile Gly Pro Gly Ile Gly Ala Leu Thr Glu Phe Leu 
    50                  55                  60                  

Ala Glu Arg Ala Ala Gln Val Met Ala Phe Glu Ile Asp His Arg Leu 
65                  70                  75                  80  

Val Pro Ile Leu Ala Asp Thr Leu Arg Asp Phe Asp Asn Val Thr Val 
                85                  90                  95      

Val Asn Glu Asp Ile Leu Lys Val Asp Leu Ala Gln His Ile Gln Asn 
            100                 105                 110         

Phe Lys Asn Pro Asp Leu Pro Ile Lys Val Val Ala Asn Leu Pro Tyr 
        115                 120                 125             

Tyr Ile Thr Thr Pro Ile Leu Met His Leu Ile Glu Ser Gly Ile Pro 
    130                 135                 140                 

Phe Cys Glu Phe Val Val Met Met Gln Lys Glu Val Ala Asp Arg Ile 
145                 150                 155                 160 

Ser Ala Gln Pro Asn Thr Lys Ala Tyr Gly Ser Leu Ser Ile Ala Val 
                165                 170                 175     

Gln Tyr Tyr Met Thr Ala Lys Val Ala Phe Ile Val Pro Arg Thr Val 
            180                 185                 190         

Phe Val Pro Ala Pro Asn Val Asp Ser Ala Ile Leu Lys Met Val Arg 
        195                 200                 205             

Arg Pro Glu Pro Ala Val Ala Val Glu Asp Glu Asn Phe Phe Phe Lys 
    210                 215                 220                 

Val Ser Lys Ala Ser Phe Thr His Arg Arg Lys Thr Leu Trp Asn Asn 
225                 230                 235                 240 

Leu Thr Gly Tyr Phe Gly Lys Thr Glu Glu Val Lys Asp Lys Leu Thr 
                245                 250                 255     

Lys Ala Leu Asp Gln Ala Gly Leu Ser Pro Ser Val Arg Gly Glu Ala 
            260                 265                 270         

Leu Ser Leu Ala Glu Phe Ala Gly Leu Ala Asp Ala Leu Lys Gly Gln 
        275                 280                 285             

Gly Leu 
    290 

<210>   4135
<211>   312
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4135
ttgctcatgt gtgaaaaaat ccgtattcgc agggtatctg attatcctag tgccagaggt   60
ggtttagaag atatcctcat catggaaaat atgaccaatc atctcctttt ggttcaaatc   120
cgagtgcatg gctatttgct tgattttgct agtattgaag ggcaaaggca aaagcattat   180
cgtttgaaaa atttacctca gacggttgaa ctgacagtgg atgatgtgga ggaggatgtg   240
gatttgaccc tacctgaaaa tcgaagttat caagaagctg atttttttga acgcatgttt   300
cgagagaact gc                                                       312

<210>   4136
<211>   104
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903842 (4.E-57)

<400>   4136
Met Leu Met Cys Glu Lys Ile Arg Ile Arg Arg Val Ser Asp Tyr Pro 
1               5                   10                  15      

Ser Ala Arg Gly Gly Leu Glu Asp Ile Leu Ile Met Glu Asn Met Thr 
            20                  25                  30          

Asn His Leu Leu Leu Val Gln Ile Arg Val His Gly Tyr Leu Leu Asp 
        35                  40                  45              

Phe Ala Ser Ile Glu Gly Gln Arg Gln Lys His Tyr Arg Leu Lys Asn 
    50                  55                  60                  

Leu Pro Gln Thr Val Glu Leu Thr Val Asp Asp Val Glu Glu Asp Val 
65                  70                  75                  80  

Asp Leu Thr Leu Pro Glu Asn Arg Ser Tyr Gln Glu Ala Asp Phe Phe 
                85                  90                  95      

Glu Arg Met Phe Arg Glu Asn Cys 
            100                 

<210>   4137
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4137
atgattgata ttcaaggatt ggaaaagaaa tttaatgacc gcgcgatttt ctctggtttg   60
aatctcaagc tggagaaggg caaggtttat gccttaatcg gaaagagtgg aagcggaaag   120
acgacgctgc tgaatatctt gggaaagcta gaaaagatag atggtggaag ggttctctat   180
caggggaaag atttaaaaac cattcccact cgtgagtatt ttcgagacca gatgggctat   240
ctctttcaaa atttcggcct cttagaaaac caatcaatca aagaaaattt ggatttgggt   300

tttgttggtc agaaaatctc aaaagtagaa cgtttggaaa ggcaagtggg ggctttagaa   360
aaagttaatc tagggtattt ggatttagaa caaaaaatct atactttatc tgggggagag   420
gcccaacgag ttgcccttgc taagactatt ttgaaaaatc cacccttgat tttggcagat   480
gaaccaacag cagctcttga tcctgaaaat tcagaggagg ttatgaatct cttggtggat   540
ttgaaagatg aaaatcgaat tatcatcatt gcgacccata atcccctagt ctggaataag   600
gctgatgaaa tcattgatat gaggaaactt gctcatgtg                          639

<210>   4138
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903843 (e-118)

<400>   4138
Met Ile Asp Ile Gln Gly Leu Glu Lys Lys Phe Asn Asp Arg Ala Ile 
1               5                   10                  15      

Phe Ser Gly Leu Asn Leu Lys Leu Glu Lys Gly Lys Val Tyr Ala Leu 
            20                  25                  30          

Ile Gly Lys Ser Gly Ser Gly Lys Thr Thr Leu Leu Asn Ile Leu Gly 
        35                  40                  45              

Lys Leu Glu Lys Ile Asp Gly Gly Arg Val Leu Tyr Gln Gly Lys Asp 
    50                  55                  60                  

Leu Lys Thr Ile Pro Thr Arg Glu Tyr Phe Arg Asp Gln Met Gly Tyr 
65                  70                  75                  80  

Leu Phe Gln Asn Phe Gly Leu Leu Glu Asn Gln Ser Ile Lys Glu Asn 
                85                  90                  95      

Leu Asp Leu Gly Phe Val Gly Gln Lys Ile Ser Lys Val Glu Arg Leu 
            100                 105                 110         

Glu Arg Gln Val Gly Ala Leu Glu Lys Val Asn Leu Gly Tyr Leu Asp 
        115                 120                 125             

Leu Glu Gln Lys Ile Tyr Thr Leu Ser Gly Gly Glu Ala Gln Arg Val 
    130                 135                 140                 

Ala Leu Ala Lys Thr Ile Leu Lys Asn Pro Pro Leu Ile Leu Ala Asp 
145                 150                 155                 160 

Glu Pro Thr Ala Ala Leu Asp Pro Glu Asn Ser Glu Glu Val Met Asn 
                165                 170                 175     

Leu Leu Val Asp Leu Lys Asp Glu Asn Arg Ile Ile Ile Ile Ala Thr 
            180                 185                 190         

His Asn Pro Leu Val Trp Asn Lys Ala Asp Glu Ile Ile Asp Met Arg 
        195                 200                 205             

Lys Leu Ala His Val 
    210             

<210>   4139
<211>   2031
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4139
atgatgaaac gtttatttat tttgatttca atggtattag tatcgcttta tatggtgata   60
acttccgttg accatcgaga agagatttta tttggtaact atccttctgt tgatgtgaca   120
ggaatgatga taaatcaacc agtagctagt cgcgaagagg tgacagaggc tttgagtcac   180
ttggcggtag agcacaatag tctcattgct cgtcgaatcg ttgagccaaa tgaagctgga   240
gaaacacgct ttacctatgc cacttatggt gagggaaagc ttccagaagg tctgaccatt   300
tcctccaagg agagtgcaga aacgagtgat ttattagggt cttacttgat tgtatcagga   360
agtttggatg gagtgagctt acagaccacc ttgaaagagc ttggttatca aggctttgtt   420
tcgaatggag aagatccatt ttcgatagtc ttactattga cggccacccc tatggtgcta   480
ctgagtttag ctatttttct gctgaccttt atgagtctga ccctgattta tcggatcaaa   540
tcccttcgtc aggcagggat tcgcttaata gctggtgaga gcttgtttgg agttgctctc   600
agaccagtgt tagaagatgt gagacagctt atctgctcag tgctggtatc cagtcttttg   660
ggattgggga ttctctggta tcaaggtgcc ttgtttatgg caacggtgca actggtcatc   720
attgctcttc tactttatgg attgaccttg gcagggattt ctaccttact aagtgtcgtc   780
tatctacttg gtttacagga aaatagtctg gtggatctat tgaaagggaa actccctctc   840
aaacgtatga tgacattgat gatggtgggg caactcttag ctgtattggt ggtcggatcg   900
agtgcgacag ctctcctacc ccactaccgt gaaatgcagg aaatggagag agctagcaat   960
aaatggagcc agtcctcaga ccgttaccgt ctatcctttg gttggtctag tgcatttgcc   1020
gatgaagaag gaacgcgtaa ggataatcgt gagtggcaga catttactga agaacggtta   1080
gccaatacag actcttttta tattatgagc aatgttgaca atttctcaga tggagcagaa   1140
gtggacctag atggcaatcg tctcagtgac tacacaccgt cagggaatgt tatctatgtc   1200
tcaccgcgct atctgataga agaaaagatt accgtttctt cagagtttat ggacaagatg   1260
caaaacttgt ctgagggaga gtttgggctg atcttgcctg agagcttgcg agagcagtct   1320
gtctactacc aaggattgtt tacagattac ctgcaaaact tttcatctga aagtgtagaa   1380
gtgacgagtc agaaacacta cctcccacag gtaaggctag cttttacaga aacaggacag   1440
gaacgtttcc tctataatga tgggtacaag acaacacgcc agtacctaaa agatccgatt   1500
attgtagttc taacgccgca agcgactgga acaagacctg ttgcagggat gttgtgggga   1560
actacggcta atagtgcctt gaaactagat cgatatggag acagcatcac agctctaaaa   1620
gagaaaggtc tgtatcacaa ggtttcttac ttggtaaaaa gccagctatt ttttgccaag   1680
gtactaaatg acaaacgggt ggagttttac tctctcctta ttgggacgat tttgaccctg   1740
tctacggcta tcttgttatt tgattccatg aatcttctct attttgagca gttcagacgg   1800
gaacttatga ttaaacgtct tgctggtatg acaatctatg agcttcatgg caagtattta   1860
ctggcgcaag gaggagttct cttgcttggc ctagtcctat ctagtatttt gacaagagat   1920
ggtttgatta gcgctctagt tgtagctttg tttacgctta acgccctctt gattttagta   1980
aggcaggaca aaaaagaaga agctggtagc atggcagtat tgaaaggaaa a            2031

<210>   4140
<211>   677
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   immunity protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903844 (0.E+01)

<400>   4140
Met Met Lys Arg Leu Phe Ile Leu Ile Ser Met Val Leu Val Ser Leu 
1               5                   10                  15      

Tyr Met Val Ile Thr Ser Val Asp His Arg Glu Glu Ile Leu Phe Gly 
            20                  25                  30          

Asn Tyr Pro Ser Val Asp Val Thr Gly Met Met Ile Asn Gln Pro Val 
        35                  40                  45              

Ala Ser Arg Glu Glu Val Thr Glu Ala Leu Ser His Leu Ala Val Glu 
    50                  55                  60                  

His Asn Ser Leu Ile Ala Arg Arg Ile Val Glu Pro Asn Glu Ala Gly 
65                  70                  75                  80  

Glu Thr Arg Phe Thr Tyr Ala Thr Tyr Gly Glu Gly Lys Leu Pro Glu 
                85                  90                  95      

Gly Leu Thr Ile Ser Ser Lys Glu Ser Ala Glu Thr Ser Asp Leu Leu 
            100                 105                 110         

Gly Ser Tyr Leu Ile Val Ser Gly Ser Leu Asp Gly Val Ser Leu Gln 
        115                 120                 125             

Thr Thr Leu Lys Glu Leu Gly Tyr Gln Gly Phe Val Ser Asn Gly Glu 
    130                 135                 140                 

Asp Pro Phe Ser Ile Val Leu Leu Leu Thr Ala Thr Pro Met Val Leu 
145                 150                 155                 160 

Leu Ser Leu Ala Ile Phe Leu Leu Thr Phe Met Ser Leu Thr Leu Ile 
                165                 170                 175     

Tyr Arg Ile Lys Ser Leu Arg Gln Ala Gly Ile Arg Leu Ile Ala Gly 
            180                 185                 190         

Glu Ser Leu Phe Gly Val Ala Leu Arg Pro Val Leu Glu Asp Val Arg 
        195                 200                 205             

Gln Leu Ile Cys Ser Val Leu Val Ser Ser Leu Leu Gly Leu Gly Ile 
    210                 215                 220                 

Leu Trp Tyr Gln Gly Ala Leu Phe Met Ala Thr Val Gln Leu Val Ile 
225                 230                 235                 240 

Ile Ala Leu Leu Leu Tyr Gly Leu Thr Leu Ala Gly Ile Ser Thr Leu 
                245                 250                 255     

Leu Ser Val Val Tyr Leu Leu Gly Leu Gln Glu Asn Ser Leu Val Asp 
            260                 265                 270         

Leu Leu Lys Gly Lys Leu Pro Leu Lys Arg Met Met Thr Leu Met Met 
        275                 280                 285             

Val Gly Gln Leu Leu Ala Val Leu Val Val Gly Ser Ser Ala Thr Ala 
    290                 295                 300                 

Leu Leu Pro His Tyr Arg Glu Met Gln Glu Met Glu Arg Ala Ser Asn 
305                 310                 315                 320 

Lys Trp Ser Gln Ser Ser Asp Arg Tyr Arg Leu Ser Phe Gly Trp Ser 
                325                 330                 335     

Ser Ala Phe Ala Asp Glu Glu Gly Thr Arg Lys Asp Asn Arg Glu Trp 
            340                 345                 350         

Gln Thr Phe Thr Glu Glu Arg Leu Ala Asn Thr Asp Ser Phe Tyr Ile 
        355                 360                 365             

Met Ser Asn Val Asp Asn Phe Ser Asp Gly Ala Glu Val Asp Leu Asp 
    370                 375                 380                 

Gly Asn Arg Leu Ser Asp Tyr Thr Pro Ser Gly Asn Val Ile Tyr Val 
385                 390                 395                 400 


Ser Pro Arg Tyr Leu Ile Glu Glu Lys Ile Thr Val Ser Ser Glu Phe 
                405                 410                 415     

Met Asp Lys Met Gln Asn Leu Ser Glu Gly Glu Phe Gly Leu Ile Leu 
            420                 425                 430         

Pro Glu Ser Leu Arg Glu Gln Ser Val Tyr Tyr Gln Gly Leu Phe Thr 
        435                 440                 445             

Asp Tyr Leu Gln Asn Phe Ser Ser Glu Ser Val Glu Val Thr Ser Gln 
    450                 455                 460                 

Lys His Tyr Leu Pro Gln Val Arg Leu Ala Phe Thr Glu Thr Gly Gln 
465                 470                 475                 480 

Glu Arg Phe Leu Tyr Asn Asp Gly Tyr Lys Thr Thr Arg Gln Tyr Leu 
                485                 490                 495     

Lys Asp Pro Ile Ile Val Val Leu Thr Pro Gln Ala Thr Gly Thr Arg 
            500                 505                 510         

Pro Val Ala Gly Met Leu Trp Gly Thr Thr Ala Asn Ser Ala Leu Lys 
        515                 520                 525             

Leu Asp Arg Tyr Gly Asp Ser Ile Thr Ala Leu Lys Glu Lys Gly Leu 
    530                 535                 540                 

Tyr His Lys Val Ser Tyr Leu Val Lys Ser Gln Leu Phe Phe Ala Lys 
545                 550                 555                 560 

Val Leu Asn Asp Lys Arg Val Glu Phe Tyr Ser Leu Leu Ile Gly Thr 
                565                 570                 575     

Ile Leu Thr Leu Ser Thr Ala Ile Leu Leu Phe Asp Ser Met Asn Leu 
            580                 585                 590         

Leu Tyr Phe Glu Gln Phe Arg Arg Glu Leu Met Ile Lys Arg Leu Ala 
        595                 600                 605             

Gly Met Thr Ile Tyr Glu Leu His Gly Lys Tyr Leu Leu Ala Gln Gly 
    610                 615                 620                 

Gly Val Leu Leu Leu Gly Leu Val Leu Ser Ser Ile Leu Thr Arg Asp 
625                 630                 635                 640 

Gly Leu Ile Ser Ala Leu Val Val Ala Leu Phe Thr Leu Asn Ala Leu 
                645                 650                 655     

Leu Ile Leu Val Arg Gln Asp Lys Lys Glu Glu Ala Gly Ser Met Ala 
            660                 665                 670         

Val Leu Lys Gly Lys 
        675         

<210>   4141
<211>   897
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4141
atgttaattg gtcaaaaaat taaagagatt cggatagaaa aaggaattag tcgtccagat   60
ttttgtggag atgagcaaga actgacagtt cgtcaactgt cgcgaattga aagtggagct   120
tcgcaaccga gtttgcccaa gttagactat attgctcgcc ggctaggagt tccagtttat   180
agccttatgc cggatttttc agctcttcct tctgcttatt tagaattgaa ataccagatt   240
ttacgtgaac caatctatgg taaagaagag gagtacgata agaaggaagc gtgtttggaa   300
gagatttata aaacatactt tgataatctt cctaaagaag aacaattagc atgtgaagta   360
ttgcaggcgt gtttggatac ttctagaact agaaggcctg aatatgcaga gttaatactt   420
gaggaacata tgcctcagat tatagaaaaa gaagcttatt caataaatga tatgttgttg   480
attcgtttgt ttttttatca aatgctcatt agaaaagatc ttgccaaatt tataaatcaa   540

atcgaaaagc taatgctctt tcttttggaa cagaagaagg taactcaaat agagaattac   600
tttataatta gagatactct tatttcagga atgtgttgtc ttgaaaaggt aggagtaact   660
gattgtttta atgattatct atcgtgttta caagaaatta tggataaaac tcaagattat   720
caaaagaaac ctcttgtatt tatgtttttg tggaagcaag cattaagaga agaaagagat   780
tttagtttag ctgaatcatt ttatcagtct tctaaaacat ttgcgcagct aattggagat   840
gaatttctag taaagaaatt gacagaggaa tggcaagagg atgtcaaaaa atattta      897

<210>   4142
<211>   299
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator PlcR, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903845 (e-168)

<400>   4142
Met Leu Ile Gly Gln Lys Ile Lys Glu Ile Arg Ile Glu Lys Gly Ile 
1               5                   10                  15      

Ser Arg Pro Asp Phe Cys Gly Asp Glu Gln Glu Leu Thr Val Arg Gln 
            20                  25                  30          

Leu Ser Arg Ile Glu Ser Gly Ala Ser Gln Pro Ser Leu Pro Lys Leu 
        35                  40                  45              

Asp Tyr Ile Ala Arg Arg Leu Gly Val Pro Val Tyr Ser Leu Met Pro 
    50                  55                  60                  

Asp Phe Ser Ala Leu Pro Ser Ala Tyr Leu Glu Leu Lys Tyr Gln Ile 
65                  70                  75                  80  

Leu Arg Glu Pro Ile Tyr Gly Lys Glu Glu Glu Tyr Asp Lys Lys Glu 
                85                  90                  95      

Ala Cys Leu Glu Glu Ile Tyr Lys Thr Tyr Phe Asp Asn Leu Pro Lys 
            100                 105                 110         

Glu Glu Gln Leu Ala Cys Glu Val Leu Gln Ala Cys Leu Asp Thr Ser 
        115                 120                 125             

Arg Thr Arg Arg Pro Glu Tyr Ala Glu Leu Ile Leu Glu Glu His Met 
    130                 135                 140                 

Pro Gln Ile Ile Glu Lys Glu Ala Tyr Ser Ile Asn Asp Met Leu Leu 
145                 150                 155                 160 

Ile Arg Leu Phe Phe Tyr Gln Met Leu Ile Arg Lys Asp Leu Ala Lys 
                165                 170                 175     

Phe Ile Asn Gln Ile Glu Lys Leu Met Leu Phe Leu Leu Glu Gln Lys 
            180                 185                 190         

Lys Val Thr Gln Ile Glu Asn Tyr Phe Ile Ile Arg Asp Thr Leu Ile 
        195                 200                 205             

Ser Gly Met Cys Cys Leu Glu Lys Val Gly Val Thr Asp Cys Phe Asn 
    210                 215                 220                 

Asp Tyr Leu Ser Cys Leu Gln Glu Ile Met Asp Lys Thr Gln Asp Tyr 
225                 230                 235                 240 

Gln Lys Lys Pro Leu Val Phe Met Phe Leu Trp Lys Gln Ala Leu Arg 
                245                 250                 255     

Glu Glu Arg Asp Phe Ser Leu Ala Glu Ser Phe Tyr Gln Ser Ser Lys 
            260                 265                 270         

Thr Phe Ala Gln Leu Ile Gly Asp Glu Phe Leu Val Lys Lys Leu Thr 
        275                 280                 285             

Glu Glu Trp Gln Glu Asp Val Lys Lys Tyr Leu 
    290                 295                 

<210>   4143
<211>   558
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4143
atgaaagaga aaatttctca agttatcgtg gttgaagggc gtgatgatac ggtcaatctc   60
aaacgttatt tcgatgtgga gacctatgag actcgaggtt ctgccatcaa tgctcaggat   120
atagagcgga ttcagcgcct gcaccaacgt catggagtca ttgtctttac agacccagat   180
tttaatgggg aacggattcg gcgcatgatc atgatggtca ttccaacagt tcagcatgcc   240
tttctcaagc gagatgaagc tgttcccaag tccaagacca aggggcgttc tctgggaatt   300
gagcatgcca gctatgaaga cctgaaaacg gctctagctc aagtgacaga acaatttgaa   360
catgagagtc agtttgacat tagtcgtagc gatttgattc gccttggttt tctagcaggg   420
gcagacagcc gtaagcgtag agaatatctc ggagagactc tccgaatcgg ctattccaac   480
ggcaagcaac tcctcaaacg cctagagttg tttggggtta ctttggcaga agtggaagaa   540
gctatgaaat cttatgag                                                 558

<210>   4144
<211>   186
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   primase-related protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903846 (e-100)

<400>   4144
Met Lys Glu Lys Ile Ser Gln Val Ile Val Val Glu Gly Arg Asp Asp 
1               5                   10                  15      

Thr Val Asn Leu Lys Arg Tyr Phe Asp Val Glu Thr Tyr Glu Thr Arg 
            20                  25                  30          

Gly Ser Ala Ile Asn Ala Gln Asp Ile Glu Arg Ile Gln Arg Leu His 
        35                  40                  45              

Gln Arg His Gly Val Ile Val Phe Thr Asp Pro Asp Phe Asn Gly Glu 
    50                  55                  60                  

Arg Ile Arg Arg Met Ile Met Met Val Ile Pro Thr Val Gln His Ala 
65                  70                  75                  80  

Phe Leu Lys Arg Asp Glu Ala Val Pro Lys Ser Lys Thr Lys Gly Arg 
                85                  90                  95      

Ser Leu Gly Ile Glu His Ala Ser Tyr Glu Asp Leu Lys Thr Ala Leu 
            100                 105                 110         

Ala Gln Val Thr Glu Gln Phe Glu His Glu Ser Gln Phe Asp Ile Ser 
        115                 120                 125             


Arg Ser Asp Leu Ile Arg Leu Gly Phe Leu Ala Gly Ala Asp Ser Arg 
    130                 135                 140                 

Lys Arg Arg Glu Tyr Leu Gly Glu Thr Leu Arg Ile Gly Tyr Ser Asn 
145                 150                 155                 160 

Gly Lys Gln Leu Leu Lys Arg Leu Glu Leu Phe Gly Val Thr Leu Ala 
                165                 170                 175     

Glu Val Glu Glu Ala Met Lys Ser Tyr Glu 
            180                 185     

<210>   4145
<211>   771
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4145
atgatttttg atacacatac acacttgaat gtagaagaat ttgcaggtcg tgaggcagaa   60
gaaattgcct tggctgctga gatgggtgtg acacagatga atattgttgg ttttgataaa   120
ccgacgattg agcatgcctt ggagttggta gatgagtatg agcagctcta tgcgactatt   180
ggttggcatc ctacagaagc tggtacttat acagaggaag ttgaggctta cttgttggat   240
aagttaaaac attccaaggt tgtggcttta ggtgaaattg gcttagatta ccattggatg   300
acagcgccca aagaggtgca ggagcaggtt tttcgccgtc agattcagct atctaaggac   360
ttggatttgc cttttgttgt ccatacccgt gatgcgctgg aagataccta tgagattatc   420
aagagtgagg gcgttggtcc tcgtggtggt atcatgcatt cattttcagg gacgcttgag   480
tgggcagaga agtttgtgga tcttggtatg accatttcct tctcaggagt ggtgactttt   540
aagaaggcaa ctgacctcca agaagcagct aaagagttac ctttggacaa gatgttggtg   600
gaaacagatg cgccttactt agcacctgta cccaagcgtg gtcgtgaaaa taaaacagcc   660
tatactcgct atgtggtcga ctttatcgct gacttgcgtg gtatgacgac agaagagctg   720
gcggtagcaa cgactgcaaa tgcagaacga atttttggac tggacagcaa g            771

<210>   4146
<211>   257
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydrolase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903847 (e-147)

<400>   4146
Met Ile Phe Asp Thr His Thr His Leu Asn Val Glu Glu Phe Ala Gly 
1               5                   10                  15      

Arg Glu Ala Glu Glu Ile Ala Leu Ala Ala Glu Met Gly Val Thr Gln 
            20                  25                  30          

Met Asn Ile Val Gly Phe Asp Lys Pro Thr Ile Glu His Ala Leu Glu 
        35                  40                  45              

Leu Val Asp Glu Tyr Glu Gln Leu Tyr Ala Thr Ile Gly Trp His Pro 
    50                  55                  60                  

Thr Glu Ala Gly Thr Tyr Thr Glu Glu Val Glu Ala Tyr Leu Leu Asp 
65                  70                  75                  80  

Lys Leu Lys His Ser Lys Val Val Ala Leu Gly Glu Ile Gly Leu Asp 
                85                  90                  95      

Tyr His Trp Met Thr Ala Pro Lys Glu Val Gln Glu Gln Val Phe Arg 
            100                 105                 110         

Arg Gln Ile Gln Leu Ser Lys Asp Leu Asp Leu Pro Phe Val Val His 
        115                 120                 125             

Thr Arg Asp Ala Leu Glu Asp Thr Tyr Glu Ile Ile Lys Ser Glu Gly 
    130                 135                 140                 

Val Gly Pro Arg Gly Gly Ile Met His Ser Phe Ser Gly Thr Leu Glu 
145                 150                 155                 160 

Trp Ala Glu Lys Phe Val Asp Leu Gly Met Thr Ile Ser Phe Ser Gly 
                165                 170                 175     

Val Val Thr Phe Lys Lys Ala Thr Asp Leu Gln Glu Ala Ala Lys Glu 
            180                 185                 190         

Leu Pro Leu Asp Lys Met Leu Val Glu Thr Asp Ala Pro Tyr Leu Ala 
        195                 200                 205             

Pro Val Pro Lys Arg Gly Arg Glu Asn Lys Thr Ala Tyr Thr Arg Tyr 
    210                 215                 220                 

Val Val Asp Phe Ile Ala Asp Leu Arg Gly Met Thr Thr Glu Glu Leu 
225                 230                 235                 240 

Ala Val Ala Thr Thr Ala Asn Ala Glu Arg Ile Phe Gly Leu Asp Ser 
                245                 250                 255     

Lys 
    

<210>   4147
<211>   891
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4147
ttggtagcac aagatccaaa agcacaagat agcactaaac tgactgctga aaaatcaact   60
gttaaagcac ctgctcaaag agtagatgta aaagatataa ctcatttaac agatgaagaa   120
aaagttaagg ttgctatttt acaagcaaat ggttcagcat tagacggagc gacaatcaat   180
gtagctggag atggtacagc aacaatcaca ttcccagatg gttcagtagt gacgattcta   240
ggaaaagata cagttcaaca atctgcgaaa ggtgaatctg taactcaaga agctacacca   300
gagtataagc tagaaaatac accaggtgga gataagggag gcaatactgg aagctcagat   360
gctaatgcga atgaaggcgg tggtagccag gcgggtggat cagctcacac aggttcacaa   420
aactcagctc aatcacaagc ttctaagcaa ttagctactg aaaaagaatc agctaaaaat   480
gccattgaaa aagcagccaa ggacaagcag gatgaaatca aaggcgcacc gctttctgat   540
aaagaaaaag cagaactttt agcaagagtg gaagcagaaa aacaagcagc tctcaaagag   600
attgaaaatg cgaaaactat ggaagatgtg aaggaagcag aaacgattgg agtgcaagcc   660
attgccatgg ttacagttcc taagagacca gtggctccta atgctgctcc taagacaaca   720
agtgcaccgc aagcaactgc aggaacaatg caagatgtta cctaccagtc acctgctggc   780
aaacaattac ctaacacagg ttcagcatca agtgcagcac ttgctagtct tggtctagtg   840
gtggcaacaa gtggttttgc tttgctagga agaaagacta gacgtagaaa a            891

<210>   4148
<211>   297
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell wall surface anchor family protein
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15903848 (e-119)

<400>   4148
Met Val Ala Gln Asp Pro Lys Ala Gln Asp Ser Thr Lys Leu Thr Ala 
1               5                   10                  15      

Glu Lys Ser Thr Val Lys Ala Pro Ala Gln Arg Val Asp Val Lys Asp 
            20                  25                  30          

Ile Thr His Leu Thr Asp Glu Glu Lys Val Lys Val Ala Ile Leu Gln 
        35                  40                  45              

Ala Asn Gly Ser Ala Leu Asp Gly Ala Thr Ile Asn Val Ala Gly Asp 
    50                  55                  60                  

Gly Thr Ala Thr Ile Thr Phe Pro Asp Gly Ser Val Val Thr Ile Leu 
65                  70                  75                  80  

Gly Lys Asp Thr Val Gln Gln Ser Ala Lys Gly Glu Ser Val Thr Gln 
                85                  90                  95      

Glu Ala Thr Pro Glu Tyr Lys Leu Glu Asn Thr Pro Gly Gly Asp Lys 
            100                 105                 110         

Gly Gly Asn Thr Gly Ser Ser Asp Ala Asn Ala Asn Glu Gly Gly Gly 
        115                 120                 125             

Ser Gln Ala Gly Gly Ser Ala His Thr Gly Ser Gln Asn Ser Ala Gln 
    130                 135                 140                 

Ser Gln Ala Ser Lys Gln Leu Ala Thr Glu Lys Glu Ser Ala Lys Asn 
145                 150                 155                 160 

Ala Ile Glu Lys Ala Ala Lys Asp Lys Gln Asp Glu Ile Lys Gly Ala 
                165                 170                 175     

Pro Leu Ser Asp Lys Glu Lys Ala Glu Leu Leu Ala Arg Val Glu Ala 
            180                 185                 190         

Glu Lys Gln Ala Ala Leu Lys Glu Ile Glu Asn Ala Lys Thr Met Glu 
        195                 200                 205             

Asp Val Lys Glu Ala Glu Thr Ile Gly Val Gln Ala Ile Ala Met Val 
    210                 215                 220                 

Thr Val Pro Lys Arg Pro Val Ala Pro Asn Ala Ala Pro Lys Thr Thr 
225                 230                 235                 240 

Ser Ala Pro Gln Ala Thr Ala Gly Thr Met Gln Asp Val Thr Tyr Gln 
                245                 250                 255     

Ser Pro Ala Gly Lys Gln Leu Pro Asn Thr Gly Ser Ala Ser Ser Ala 
            260                 265                 270         


Ala Leu Ala Ser Leu Gly Leu Val Val Ala Thr Ser Gly Phe Ala Leu 
        275                 280                 285             

Leu Gly Arg Lys Thr Arg Arg Arg Lys 
    290                 295         

<210>   4149
<211>   132
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4149
gtgaaacgta cttatcaacc aagtaaactt cgtcgtgcgc gcaaacacgg attccgtaac   60
cgtatgtcaa ctaaaaatgg tcgtcgcgta ttggcagctc gtcgtcgtaa aggacgcaaa   120
gttttggctg ca                                                       132

<210>   4150
<211>   44
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L34 (rpmH)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903849 (1.E-20)

<400>   4150
Met Lys Arg Thr Tyr Gln Pro Ser Lys Leu Arg Arg Ala Arg Lys His 
1               5                   10                  15      

Gly Phe Arg Asn Arg Met Ser Thr Lys Asn Gly Arg Arg Val Leu Ala 
            20                  25                  30          

Ala Arg Arg Arg Lys Gly Arg Lys Val Leu Ala Ala 
        35                  40                  

<210>   4151
<211>   1212
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4151
atgaaagaat ataacaagtc tagtaagtta gagcatgttg cttatgatat ccgtggtcct   60
gtattggaag aagccatgcg gatgcgagcg aatggagaaa agattttacg tctgaataca   120
ggaaatccag cagaatttgg ctttacagcg ccagacgagg tcattcatga cttgattatg   180
aatgcgcgtg atagtgaagg ctattctgac tccaaaggga ttttctcagc ccgtaaggcc   240
atcatgcagt attgccagct gaagaaattc ccaaacgtag atactgatga tatttacctt   300
ggaaatggtg tcagtgagtt gattgtcatg tccatgcagg ggcttttgga caatggggat   360
gaggtcttag tgccaatgcc agactatcct ctatggacgg cggctgtcag cctagctgga   420
ggaaatgccg ttcactatat ctgtgatgaa gctgtggaat ggtacccaga tattgacgat   480
atcaagtcaa aaatcacttc caataccaag gcaattgtcc ttatcaatcc aaataaccca   540
actggagccc tttatcctaa ggaactcttg ctggagatta ttgagattgc ccgtcaaaac   600
gatttgatta tctttgcgga tgaaatctat gaccgcatgg taatggacgg acatgtgcat   660
acgcctgtgg cgagcttggc accagatgtc ttctgtgtca gcatgaatgg tctgtcaaaa   720
tcccaccgca tagcaggttt ccgtgtgggt tggatggtct tgtctggccc taagactcat   780
gttaagggct atatcgaagg gctcaatatg ctgtccaata tgcgcctttg ctctaacgtt   840
ttggcccaac aagtcgtaca aacttccttg gggggtcacc aatcagtcga tgaattgctt   900
cttcctggtg gacgaatcta cgagcaaaga aatttcatct ataatgccat tcaagatatt   960
ccaggtttgt ctgccgttaa acccaaggcg gggctctata tcttcccaaa aatcgaccgc   1020
aatatgtacc gtatcgatga tgatgagcag tttgtccttg atttcttgaa gcaggaaaag   1080
gttctcttgg ttcatggtcg aggctttaac tggcaggaac cagaccactt ccgtatcgtt   1140
taccttcctc gtgttgatga gttagcccaa atccaagaaa agatgactcg tttcttgaaa   1200
cagtatcgta ga                                                       1212

<210>   4152
<211>   404
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aminotransferase, class I
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903850 (0.E+01)

<400>   4152
Met Lys Glu Tyr Asn Lys Ser Ser Lys Leu Glu His Val Ala Tyr Asp 
1               5                   10                  15      

Ile Arg Gly Pro Val Leu Glu Glu Ala Met Arg Met Arg Ala Asn Gly 
            20                  25                  30          

Glu Lys Ile Leu Arg Leu Asn Thr Gly Asn Pro Ala Glu Phe Gly Phe 
        35                  40                  45              

Thr Ala Pro Asp Glu Val Ile His Asp Leu Ile Met Asn Ala Arg Asp 
    50                  55                  60                  


Ser Glu Gly Tyr Ser Asp Ser Lys Gly Ile Phe Ser Ala Arg Lys Ala 
65                  70                  75                  80  

Ile Met Gln Tyr Cys Gln Leu Lys Lys Phe Pro Asn Val Asp Thr Asp 
                85                  90                  95      

Asp Ile Tyr Leu Gly Asn Gly Val Ser Glu Leu Ile Val Met Ser Met 
            100                 105                 110         

Gln Gly Leu Leu Asp Asn Gly Asp Glu Val Leu Val Pro Met Pro Asp 
        115                 120                 125             

Tyr Pro Leu Trp Thr Ala Ala Val Ser Leu Ala Gly Gly Asn Ala Val 
    130                 135                 140                 

His Tyr Ile Cys Asp Glu Ala Val Glu Trp Tyr Pro Asp Ile Asp Asp 
145                 150                 155                 160 

Ile Lys Ser Lys Ile Thr Ser Asn Thr Lys Ala Ile Val Leu Ile Asn 
                165                 170                 175     

Pro Asn Asn Pro Thr Gly Ala Leu Tyr Pro Lys Glu Leu Leu Leu Glu 
            180                 185                 190         

Ile Ile Glu Ile Ala Arg Gln Asn Asp Leu Ile Ile Phe Ala Asp Glu 
        195                 200                 205             

Ile Tyr Asp Arg Met Val Met Asp Gly His Val His Thr Pro Val Ala 
    210                 215                 220                 

Ser Leu Ala Pro Asp Val Phe Cys Val Ser Met Asn Gly Leu Ser Lys 
225                 230                 235                 240 

Ser His Arg Ile Ala Gly Phe Arg Val Gly Trp Met Val Leu Ser Gly 
                245                 250                 255     

Pro Lys Thr His Val Lys Gly Tyr Ile Glu Gly Leu Asn Met Leu Ser 
            260                 265                 270         

Asn Met Arg Leu Cys Ser Asn Val Leu Ala Gln Gln Val Val Gln Thr 
        275                 280                 285             

Ser Leu Gly Gly His Gln Ser Val Asp Glu Leu Leu Leu Pro Gly Gly 
    290                 295                 300                 

Arg Ile Tyr Glu Gln Arg Asn Phe Ile Tyr Asn Ala Ile Gln Asp Ile 
305                 310                 315                 320 

Pro Gly Leu Ser Ala Val Lys Pro Lys Ala Gly Leu Tyr Ile Phe Pro 
                325                 330                 335     

Lys Ile Asp Arg Asn Met Tyr Arg Ile Asp Asp Asp Glu Gln Phe Val 
            340                 345                 350         

Leu Asp Phe Leu Lys Gln Glu Lys Val Leu Leu Val His Gly Arg Gly 
        355                 360                 365             

Phe Asn Trp Gln Glu Pro Asp His Phe Arg Ile Val Tyr Leu Pro Arg 
    370                 375                 380                 

Val Asp Glu Leu Ala Gln Ile Gln Glu Lys Met Thr Arg Phe Leu Lys 
385                 390                 395                 400 


Gln Tyr Arg Arg 
                

<210>   4153
<211>   408
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4153
atgatgaaaa actcttttca aaaatcaaat ttcctttatt atggaattat cctagtttca   60
gtcttggtag aagtgatcat gatctgtcaa ttagagagtc tggtaccgct tctttatcca   120
agttttattg gatttttagt ttttcatgta ctctaccatc taatcttatt tctagttgca   180
aaacgaagtg ggcgttggga ttacttgatg atatgggggc ttttcctcat gtttaatctt   240
ctttatgact cctttctagg cttgcttttt tctaggttta tcttttggta tgtgatgtgt   300
ctttgcaaaa tacctgctat ctctacgttc ttaacctcgc ctttagcaag gtttttcttc   360
tatacgaaac tagtaacaca tttcagtaaa cttgtcgcat tctctttc                408

<210>   4154
<211>   136
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903851 (3.E-48)

<400>   4154
Met Met Lys Asn Ser Phe Gln Lys Ser Asn Phe Leu Tyr Tyr Gly Ile 
1               5                   10                  15      

Ile Leu Val Ser Val Leu Val Glu Val Ile Met Ile Cys Gln Leu Glu 
            20                  25                  30          

Ser Leu Val Pro Leu Leu Tyr Pro Ser Phe Ile Gly Phe Leu Val Phe 
        35                  40                  45              

His Val Leu Tyr His Leu Ile Leu Phe Leu Val Ala Lys Arg Ser Gly 
    50                  55                  60                  

Arg Trp Asp Tyr Leu Met Ile Trp Gly Leu Phe Leu Met Phe Asn Leu 
65                  70                  75                  80  

Leu Tyr Asp Ser Phe Leu Gly Leu Leu Phe Ser Arg Phe Ile Phe Trp 
                85                  90                  95      

Tyr Val Met Cys Leu Cys Lys Ile Pro Ala Ile Ser Thr Phe Leu Thr 
            100                 105                 110         

Ser Pro Leu Ala Arg Phe Phe Phe Tyr Thr Lys Leu Val Thr His Phe 
        115                 120                 125             

Ser Lys Leu Val Ala Phe Ser Phe 
    130                 135     

<210>   4155
<211>   450
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4155
atggcacaac gttaccaaaa tatcatggtc gcaatcgatg gttctaagga agcggacttg   60
gcttttgtca agggagttca ttctgctcta cgaaacgacg ctaaactcac catcgcacat   120
gtcattgaca cacgcgctct ccaaagcgta tccacctttg atgctgaagt ttacgaagaa   180
ctccaagtcg acgctgaaag tctgatgaaa gagtacgaaa aacgtgctaa agatgctggg   240
gtagcagatg ttcatatcgt cattgaaatg ggaaatccaa agaccctgct agcacgtact   300
attccagatg ccgaggaagt ggacctcatc ctcgttggcg caactggtct caacgccttt   360
gaacgcctct tggtcggctc ttcatctgaa tacatactcc gccatgctaa ggtcgatttg   420
ctggttgtga gagaacaaga aaaaacctta                                    450

<210>   4156
<211>   150
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   universal stress protein family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903852 (1.E-78)

<400>   4156
Met Ala Gln Arg Tyr Gln Asn Ile Met Val Ala Ile Asp Gly Ser Lys 
1               5                   10                  15      

Glu Ala Asp Leu Ala Phe Val Lys Gly Val His Ser Ala Leu Arg Asn 
            20                  25                  30          

Asp Ala Lys Leu Thr Ile Ala His Val Ile Asp Thr Arg Ala Leu Gln 
        35                  40                  45              

Ser Val Ser Thr Phe Asp Ala Glu Val Tyr Glu Glu Leu Gln Val Asp 
    50                  55                  60                  

Ala Glu Ser Leu Met Lys Glu Tyr Glu Lys Arg Ala Lys Asp Ala Gly 
65                  70                  75                  80  

Val Ala Asp Val His Ile Val Ile Glu Met Gly Asn Pro Lys Thr Leu 
                85                  90                  95      

Leu Ala Arg Thr Ile Pro Asp Ala Glu Glu Val Asp Leu Ile Leu Val 
            100                 105                 110         

Gly Ala Thr Gly Leu Asn Ala Phe Glu Arg Leu Leu Val Gly Ser Ser 
        115                 120                 125             

Ser Glu Tyr Ile Leu Arg His Ala Lys Val Asp Leu Leu Val Val Arg 
    130                 135                 140                 

Glu Gln Glu Lys Thr Leu 
145                 150 

<210>   4157
<211>   1416
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4157
ttgtatcaca aaaggggaga ttgggatagg atggaagtca aagctgtttt ttttgatatc   60
gatggaacct tggtcaacaa tcgcaagagt gttttgaaat ccactaagga tgcgattaag   120
attgtcaaag aacaaggggt actagttggc gtagcgacag ggcgaggacc tttttttgtt   180
aaggaattga tggacgattt ggatctggat tttgcggtaa cctataatgg ccagtatatc   240
tttagtaaag acagagtctt gttcacgagc cctatttcca agttacattt gcgccatcta   300
attagctatg ctaaaaaaga gggcacggag attgctctag ggaccaagga tgccatgttg   360
ggttctaaaa tcatgtcctt tggtctgggt tctttttccc aacgaattag tcgcttcgtt   420
ccctctgttt taactcggac ggtgagtcag tcttttaatc gcatggtcag caaggttgtt   480
ccccaaaagg aagaggacct gcttcacctg atgaatcagc ctatctacca agttttgatg   540
ctgatgacac cagaagaatc tgagaaggcg gcagctgatt ttgaagactt gaaattgaca   600
cgtagcaatc cttttgcatc ggatgtcatc aatcagggaa attctaaatt agaaggcatt   660
cgccgagttg ggaaagaata tggctttgac ctcaaccaag tcatggcttt tggtgactca   720
gataatgatc ttgaaatgct ggctggcgtt ggtatgtcgg tcgctatggg aaatggtagt   780
agcagtgtca aggaagctgc caagcacatt accactagca atcaacaaga tggaatccac   840
aaggccttgg aacattttgg tgttttgtct tcagaaaaag tctttgtcag ccgtgactat   900
catttcaata aggtcaagac cttccaccac atgatggatg aacgaaccca agaagaacct   960
cgagcttggg atttagaggg tgcaacccat agggctggtt ttaaaataga agaattggtg   1020
gagtttgttc gagcagccag tccttctgaa gaagattttg gtcaagctgt atcgcaactt   1080
catcaggccc ttgataaggc agcagataaa gtagccaaga agacacctgc tcagcaagat   1140
ttgatagggc aagtggatgc cttgattgac acgctttact tcacctacgg cagttttgtc   1200
ttgatggggg tggacccaga acgtattttt gatattgtcc atcaggccaa tatggggaaa   1260
atttttccag atggcaaggc tcattttgat ccagtgaccc ataaaatctt aaaaccagat   1320
aattgggaag aaaaatatgc tccagaacct gctattaaaa aggaactgca gcgccagctc   1380
aaggcttacg aacgccataa agagagaaat aaatcg                             1416

<210>   4158
<211>   472
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   Cof family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903853 (0.E+01)

<400>   4158
Met Tyr His Lys Arg Gly Asp Trp Asp Arg Met Glu Val Lys Ala Val 
1               5                   10                  15      

Phe Phe Asp Ile Asp Gly Thr Leu Val Asn Asn Arg Lys Ser Val Leu 
            20                  25                  30          

Lys Ser Thr Lys Asp Ala Ile Lys Ile Val Lys Glu Gln Gly Val Leu 
        35                  40                  45              

Val Gly Val Ala Thr Gly Arg Gly Pro Phe Phe Val Lys Glu Leu Met 
    50                  55                  60                  

Asp Asp Leu Asp Leu Asp Phe Ala Val Thr Tyr Asn Gly Gln Tyr Ile 
65                  70                  75                  80  

Phe Ser Lys Asp Arg Val Leu Phe Thr Ser Pro Ile Ser Lys Leu His 
                85                  90                  95      

Leu Arg His Leu Ile Ser Tyr Ala Lys Lys Glu Gly Thr Glu Ile Ala 
            100                 105                 110         

Leu Gly Thr Lys Asp Ala Met Leu Gly Ser Lys Ile Met Ser Phe Gly 
        115                 120                 125             

Leu Gly Ser Phe Ser Gln Arg Ile Ser Arg Phe Val Pro Ser Val Leu 
    130                 135                 140                 

Thr Arg Thr Val Ser Gln Ser Phe Asn Arg Met Val Ser Lys Val Val 
145                 150                 155                 160 

Pro Gln Lys Glu Glu Asp Leu Leu His Leu Met Asn Gln Pro Ile Tyr 
                165                 170                 175     

Gln Val Leu Met Leu Met Thr Pro Glu Glu Ser Glu Lys Ala Ala Ala 
            180                 185                 190         

Asp Phe Glu Asp Leu Lys Leu Thr Arg Ser Asn Pro Phe Ala Ser Asp 
        195                 200                 205             

Val Ile Asn Gln Gly Asn Ser Lys Leu Glu Gly Ile Arg Arg Val Gly 
    210                 215                 220                 

Lys Glu Tyr Gly Phe Asp Leu Asn Gln Val Met Ala Phe Gly Asp Ser 
225                 230                 235                 240 

Asp Asn Asp Leu Glu Met Leu Ala Gly Val Gly Met Ser Val Ala Met 
                245                 250                 255     

Gly Asn Gly Ser Ser Ser Val Lys Glu Ala Ala Lys His Ile Thr Thr 
            260                 265                 270         

Ser Asn Gln Gln Asp Gly Ile His Lys Ala Leu Glu His Phe Gly Val 
        275                 280                 285             

Leu Ser Ser Glu Lys Val Phe Val Ser Arg Asp Tyr His Phe Asn Lys 
    290                 295                 300                 

Val Lys Thr Phe His His Met Met Asp Glu Arg Thr Gln Glu Glu Pro 
305                 310                 315                 320 

Arg Ala Trp Asp Leu Glu Gly Ala Thr His Arg Ala Gly Phe Lys Ile 
                325                 330                 335     

Glu Glu Leu Val Glu Phe Val Arg Ala Ala Ser Pro Ser Glu Glu Asp 
            340                 345                 350         

Phe Gly Gln Ala Val Ser Gln Leu His Gln Ala Leu Asp Lys Ala Ala 
        355                 360                 365             

Asp Lys Val Ala Lys Lys Thr Pro Ala Gln Gln Asp Leu Ile Gly Gln 
    370                 375                 380                 

Val Asp Ala Leu Ile Asp Thr Leu Tyr Phe Thr Tyr Gly Ser Phe Val 
385                 390                 395                 400 

Leu Met Gly Val Asp Pro Glu Arg Ile Phe Asp Ile Val His Gln Ala 
                405                 410                 415     

Asn Met Gly Lys Ile Phe Pro Asp Gly Lys Ala His Phe Asp Pro Val 
            420                 425                 430         

Thr His Lys Ile Leu Lys Pro Asp Asn Trp Glu Glu Lys Tyr Ala Pro 
        435                 440                 445             

Glu Pro Ala Ile Lys Lys Glu Leu Gln Arg Gln Leu Lys Ala Tyr Glu 
    450                 455                 460                 

Arg His Lys Glu Arg Asn Lys Ser 
465                 470         

<210>   4159
<211>   960
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4159
atgcctaaga aaatccttgt tttacatacg ggtggaacta tttccatgca ggccgatgct   60
tctggcgctg ttgtgacgag ttcagataat cccatgaacc atgtgtccaa cccacttgaa   120
ggaatccaag tccacgcctt ggactttttt aaccttccaa gtccccatat caaacccaaa   180
catatgctgg tcctctacca gaaaattaaa gaggaagcag ataactacga tggagtggtg   240
atcacacacg gaaccgatac tttagaggaa acagcctatt tccttgatac catggaagtt   300
ccccatatgc ctatcgttct aacaggagcc atgcgtagct ccaatgagct cggtagtgat   360
ggtgtttata attacctaag tgctttacga gtggccagcg atgacagggc tgctgacaaa   420
ggagttttgg tcgttatgaa cgatgaaatc cacgctgcca agtatgtcac caaaacacat   480
acgactaatg tcagcacctt ccagactcca acacatggcc cccttggtct catcatgaaa   540
caggaaatcc tctacttcaa aacagctgaa cctcgtgttc gctttgacct tgatcacata   600
caaggtttag tccctatcat ctcggcttat gctggtatga cagatgagct gattgatatg   660
ctggatttag aacacttgga cggtttgatt atccaagcct tcggagctgg taatattccc   720
aaagaaacgg ctcaaaaatt agaaagcctt ctgcaaaaag gaattccagt cgctctggta   780
tcacgatgct ttaacggtat tgccgagcct gtttatgcat accagggtgg gggcgtacag   840
ttgcaaaaag caggcgtttt ctttgttaaa gaactcaacg cccaaaaagc tcgcttgaaa   900
ctcctcatcg ccctcaatgc cggactaaca ggacaggctt tgaaagacta tatggaaggc   960

<210>   4160
<211>   320
<212>   PRT
<213>   Streptococcus pneumoniae


<220>
<223>   L-asparaginase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903854 (0.E+01)

<400>   4160
Met Pro Lys Lys Ile Leu Val Leu His Thr Gly Gly Thr Ile Ser Met 
1               5                   10                  15      

Gln Ala Asp Ala Ser Gly Ala Val Val Thr Ser Ser Asp Asn Pro Met 
            20                  25                  30          

Asn His Val Ser Asn Pro Leu Glu Gly Ile Gln Val His Ala Leu Asp 
        35                  40                  45              

Phe Phe Asn Leu Pro Ser Pro His Ile Lys Pro Lys His Met Leu Val 
    50                  55                  60                  

Leu Tyr Gln Lys Ile Lys Glu Glu Ala Asp Asn Tyr Asp Gly Val Val 
65                  70                  75                  80  

Ile Thr His Gly Thr Asp Thr Leu Glu Glu Thr Ala Tyr Phe Leu Asp 
                85                  90                  95      

Thr Met Glu Val Pro His Met Pro Ile Val Leu Thr Gly Ala Met Arg 
            100                 105                 110         

Ser Ser Asn Glu Leu Gly Ser Asp Gly Val Tyr Asn Tyr Leu Ser Ala 
        115                 120                 125             

Leu Arg Val Ala Ser Asp Asp Arg Ala Ala Asp Lys Gly Val Leu Val 
    130                 135                 140                 

Val Met Asn Asp Glu Ile His Ala Ala Lys Tyr Val Thr Lys Thr His 
145                 150                 155                 160 

Thr Thr Asn Val Ser Thr Phe Gln Thr Pro Thr His Gly Pro Leu Gly 
                165                 170                 175     

Leu Ile Met Lys Gln Glu Ile Leu Tyr Phe Lys Thr Ala Glu Pro Arg 
            180                 185                 190         

Val Arg Phe Asp Leu Asp His Ile Gln Gly Leu Val Pro Ile Ile Ser 
        195                 200                 205             

Ala Tyr Ala Gly Met Thr Asp Glu Leu Ile Asp Met Leu Asp Leu Glu 
    210                 215                 220                 

His Leu Asp Gly Leu Ile Ile Gln Ala Phe Gly Ala Gly Asn Ile Pro 
225                 230                 235                 240 

Lys Glu Thr Ala Gln Lys Leu Glu Ser Leu Leu Gln Lys Gly Ile Pro 
                245                 250                 255     

Val Ala Leu Val Ser Arg Cys Phe Asn Gly Ile Ala Glu Pro Val Tyr 
            260                 265                 270         

Ala Tyr Gln Gly Gly Gly Val Gln Leu Gln Lys Ala Gly Val Phe Phe 
        275                 280                 285             

Val Lys Glu Leu Asn Ala Gln Lys Ala Arg Leu Lys Leu Leu Ile Ala 
    290                 295                 300                 

Leu Asn Ala Gly Leu Thr Gly Gln Ala Leu Lys Asp Tyr Met Glu Gly 
305                 310                 315                 320 


<210>   4161
<211>   561
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4161
atgaatacca tagagcggac taggcggctg attaaaggct gcgcaacaca ctgttttgag   60
gttgtagata gaactgacga agtcagctca aagcactgct ttgaggttgc agatagaact   120
gacgaagtca gctcaaaaca tgtttttgag gttgtagatg aaactaacga agtcagctca   180
aaacatgttt ttgaggttgt agatgaaact aacgaagtca gctcaaaaca tgtttttgag   240
gttgtagata gaactgacga agtcagctca aaacatgttt ttgaggttgt agatagaact   300
gacgaagtca gctcaaaaca tgtttttgag gttgtagata gaactgacga agtcagctca   360
aaacatgttt ttgaggttgt agatagaact gacgaagtca gctcaaaaca tgtttttgag   420
gttgtagata gaactgacga agtcagctca aaacatgttt ttgaggttgt agatagaact   480
gacgaagtca gctcaaaaca tgtttttgag gttgtagatg aaactgacga agtcagtaac   540
catacatacg gtaaggcgac g                                             561

<210>   4162
<211>   187
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4162
Met Asn Thr Ile Glu Arg Thr Arg Arg Leu Ile Lys Gly Cys Ala Thr 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Cys Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser Ser Lys His Val 
        35                  40                  45              

Phe Glu Val Val Asp Glu Thr Asn Glu Val Ser Ser Lys His Val Phe 
    50                  55                  60                  

Glu Val Val Asp Glu Thr Asn Glu Val Ser Ser Lys His Val Phe Glu 
65                  70                  75                  80  


Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Val Phe Glu Val 
                85                  90                  95      

Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Val Phe Glu Val Val 
            100                 105                 110         

Asp Arg Thr Asp Glu Val Ser Ser Lys His Val Phe Glu Val Val Asp 
        115                 120                 125             

Arg Thr Asp Glu Val Ser Ser Lys His Val Phe Glu Val Val Asp Arg 
    130                 135                 140                 

Thr Asp Glu Val Ser Ser Lys His Val Phe Glu Val Val Asp Arg Thr 
145                 150                 155                 160 

Asp Glu Val Ser Ser Lys His Val Phe Glu Val Val Asp Glu Thr Asp 
                165                 170                 175     

Glu Val Ser Asn His Thr Tyr Gly Lys Ala Thr 
            180                 185         

<210>   4163
<211>   1038
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4163
atgtgtgaga tagaaaggac aggaaaagga atgaatgcag atgatacagt aaccatttat   60
gatgtcgctc gtgaagcagg tgtttccatg gcgacggtca gccgtgtggt caatggcaat   120
aaaaatgtaa aagagaatac ccgtaaaaaa gtgctagagg taattgatcg tttggattat   180
cgtccaaatg cagttgcgcg tggtcttgca agtaaaaaga caaccactgt cggtgtcgtg   240

attccaaata ttaccaatgg ttatttttcg agtttggcta aggggattga tgatattgca   300
gaaatgtaca agtacaatat tgtcctagct aatagcgatg aagataacga gaaagaagtt   360
tctgttgtca ataccctctt ttcaaagcag gtagatggca ttatctatat ggggtatcac   420
ttgacagata aaattcgctc agaattttcg cgttcacgta ctccgattgt tctcgcagga   480
actgtcgatg ttgagcacca gttgccaagt gtcaatattg actataagca agcaacaatt   540
gatgcagtga gttaccttgc taaagaaaat gagcgtattg ctttcgttag cggtccgcta   600
gtggatgaca tcaatggtaa ggttcgttta gttggctaca aggaaacctt gaaaaaagca   660
ggaatcactt atagtgaggg tttggtattt gaatctaaat atagctatga tgatggttac   720
gccttagcag agcgtttgat ttcatcaaat gcaactgcag cagttgtgac aggtgatgag   780
ttggcagcag gagtcttgaa cggtttggct gataagggtg tttctgtgcc agaagatttt   840
gaaattatta ctagtgatga ttcacaaatc tcacgcttta cccgtccaaa cttgacaacg   900
attgcccaac ctctttatga ccttggtgcc attagtatgc gtatgttgac caagattatg   960
cataaggaag agttggaaga acgtgaagtt ctcttacctc atggtttgac agaacgtagc   1020
tcaacacgaa aacgtaaa                                                 1038


<210>   4164
<211>   346
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   catabolite control protein A (ccpA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903855 (0.E+01)

<400>   4164
Met Cys Glu Ile Glu Arg Thr Gly Lys Gly Met Asn Ala Asp Asp Thr 
1               5                   10                  15      

Val Thr Ile Tyr Asp Val Ala Arg Glu Ala Gly Val Ser Met Ala Thr 
            20                  25                  30          

Val Ser Arg Val Val Asn Gly Asn Lys Asn Val Lys Glu Asn Thr Arg 
        35                  40                  45              

Lys Lys Val Leu Glu Val Ile Asp Arg Leu Asp Tyr Arg Pro Asn Ala 
    50                  55                  60                  

Val Ala Arg Gly Leu Ala Ser Lys Lys Thr Thr Thr Val Gly Val Val 
65                  70                  75                  80  

Ile Pro Asn Ile Thr Asn Gly Tyr Phe Ser Ser Leu Ala Lys Gly Ile 
                85                  90                  95      

Asp Asp Ile Ala Glu Met Tyr Lys Tyr Asn Ile Val Leu Ala Asn Ser 
            100                 105                 110         

Asp Glu Asp Asn Glu Lys Glu Val Ser Val Val Asn Thr Leu Phe Ser 
        115                 120                 125             

Lys Gln Val Asp Gly Ile Ile Tyr Met Gly Tyr His Leu Thr Asp Lys 
    130                 135                 140                 

Ile Arg Ser Glu Phe Ser Arg Ser Arg Thr Pro Ile Val Leu Ala Gly 
145                 150                 155                 160 

Thr Val Asp Val Glu His Gln Leu Pro Ser Val Asn Ile Asp Tyr Lys 
                165                 170                 175     

Gln Ala Thr Ile Asp Ala Val Ser Tyr Leu Ala Lys Glu Asn Glu Arg 
            180                 185                 190         

Ile Ala Phe Val Ser Gly Pro Leu Val Asp Asp Ile Asn Gly Lys Val 
        195                 200                 205             

Arg Leu Val Gly Tyr Lys Glu Thr Leu Lys Lys Ala Gly Ile Thr Tyr 
    210                 215                 220                 

Ser Glu Gly Leu Val Phe Glu Ser Lys Tyr Ser Tyr Asp Asp Gly Tyr 
225                 230                 235                 240 

Ala Leu Ala Glu Arg Leu Ile Ser Ser Asn Ala Thr Ala Ala Val Val 
                245                 250                 255     

Thr Gly Asp Glu Leu Ala Ala Gly Val Leu Asn Gly Leu Ala Asp Lys 
            260                 265                 270         

Gly Val Ser Val Pro Glu Asp Phe Glu Ile Ile Thr Ser Asp Asp Ser 
        275                 280                 285             

Gln Ile Ser Arg Phe Thr Arg Pro Asn Leu Thr Thr Ile Ala Gln Pro 
    290                 295                 300                 

Leu Tyr Asp Leu Gly Ala Ile Ser Met Arg Met Leu Thr Lys Ile Met 
305                 310                 315                 320 

His Lys Glu Glu Leu Glu Glu Arg Glu Val Leu Leu Pro His Gly Leu 
                325                 330                 335     

Thr Glu Arg Ser Ser Thr Arg Lys Arg Lys 
            340                 345     

<210>   4165
<211>   597
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4165
atgaaagtat tagtcgcaga agatcaaagt atgttgcgag atgccatgtg ccagttgctc   60
atgcttcaac cggatgtaga gtctgtcttt caagccaaga atgggcaaga agcaatccaa   120
ctattagaaa aggagtctgt agatatcgcc atccttgacg tagaaatgcc tgttaagaca   180
ggtcttgaag tcttggagtg gatacgagca gaaaagcttg aaacaaaggt ggttgtggtg   240
acgaccttca agcgtcctgg gtattttgaa cgtgcggtca aggctggagt agatgcttat   300
gtattaaaag aaagaaacat tgcagacctc atgcaaacct tgcacaccgt cctcgaagga   360
cgcaaggagt attcgcctga attgatggaa gtggtgatga tgcatcccaa tccattaacg   420
gagcaagaaa tcgcagtttt aaagggaatt gctcagggct tctctaacca agaaattgca   480
gacaaacttt atctatccaa cggaacagtc cgaaactatg tcaccaatat tctttcgaaa   540
ctagatgcag gtaatcgaac agaggcagct aatatcgcga aagaatctgg ttggtta      597

<210>   4166
<211>   199
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903856 (e-102)

<400>   4166
Met Lys Val Leu Val Ala Glu Asp Gln Ser Met Leu Arg Asp Ala Met 
1               5                   10                  15      

Cys Gln Leu Leu Met Leu Gln Pro Asp Val Glu Ser Val Phe Gln Ala 
            20                  25                  30          

Lys Asn Gly Gln Glu Ala Ile Gln Leu Leu Glu Lys Glu Ser Val Asp 
        35                  40                  45              

Ile Ala Ile Leu Asp Val Glu Met Pro Val Lys Thr Gly Leu Glu Val 
    50                  55                  60                  

Leu Glu Trp Ile Arg Ala Glu Lys Leu Glu Thr Lys Val Val Val Val 

65                  70                  75                  80  

Thr Thr Phe Lys Arg Pro Gly Tyr Phe Glu Arg Ala Val Lys Ala Gly 
                85                  90                  95      

Val Asp Ala Tyr Val Leu Lys Glu Arg Asn Ile Ala Asp Leu Met Gln 
            100                 105                 110         

Thr Leu His Thr Val Leu Glu Gly Arg Lys Glu Tyr Ser Pro Glu Leu 
        115                 120                 125             

Met Glu Val Val Met Met His Pro Asn Pro Leu Thr Glu Gln Glu Ile 
    130                 135                 140                 

Ala Val Leu Lys Gly Ile Ala Gln Gly Phe Ser Asn Gln Glu Ile Ala 
145                 150                 155                 160 

Asp Lys Leu Tyr Leu Ser Asn Gly Thr Val Arg Asn Tyr Val Thr Asn 
                165                 170                 175     

Ile Leu Ser Lys Leu Asp Ala Gly Asn Arg Thr Glu Ala Ala Asn Ile 
            180                 185                 190         

Ala Lys Glu Ser Gly Trp Leu 
        195                 

<210>   4167
<211>   1095
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4167
atgcttgaaa gactgaaaag aatacattat atgttttgga tcagtttaat ttttatgatt   60
ttccccatcc tgtctgtagt gactgggtgg ctttctgcct ggcatttatt gattgatatt   120
ctatttgtag tggcatattt gggtgtttta acaactaaga gccagcgcct atcttggcta   180
tattggggcc tcatgctgac ttatgtagtt gggaatactg cctttgttgc tgttaattat   240
atctggtttt tctttttcct atccaatctc ttaagttatc atttcagcgt acgtagttta   300
aagtctttac atgtctggac ttttcttctt gctcaagtcc ttgttgtggg gcaactgttg   360
atttttcaga gaatcgaagt tgagtttcta ttctatctac ttgtaattct tacttttgtc   420
gatttaatga cttttggatt ggttcggatt cgtattgtcg aggatttgaa agaagctcag   480
gtcaagcaaa atgctcagat aaatctattg cttgctgaaa atgaacgtag tcgtatcggt   540
caggatttgc atgatagtct gggacatacc tttgctatgc tgagtgtcaa gacagattta   600
gccttgcagt tatttcagat ggaggcttat ccacaggtgg aaaaggaatt aaaagaaatt   660
caccagatca gcaaggattc catgaatgaa gtgcgaacca ttgtggaaaa tcttaagtct   720
agaactttga catccgaact agagactgtg aaaaagatgt tagaaattgc tggaattgag   780
gttcaagttg agaatcactt ggacaagtct agcttaactc aggaattgga gtcaacggct   840
tccatgattt tgcttgaatt agtgaccaat atcatcaaac atgctaaagc gtctaaagtc   900
tacttgaaat tagaacggac agagaaagaa ctcattctaa cagtgagaga tgatggctgt   960
ggctttgcct ctataagcgg ggatgagctc catacagtcc gaaatcgtgt ttttccattt   1020
tcaggagaag taagtgtaat cagtcagaaa catccaactg aagtgcaggt tcgactactt   1080
tataaggaga gaaag                                                    1095

<210>   4168
<211>   365
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903857 (0.E+01)

<400>   4168
Met Leu Glu Arg Leu Lys Arg Ile His Tyr Met Phe Trp Ile Ser Leu 
1               5                   10                  15      

Ile Phe Met Ile Phe Pro Ile Leu Ser Val Val Thr Gly Trp Leu Ser 
            20                  25                  30          

Ala Trp His Leu Leu Ile Asp Ile Leu Phe Val Val Ala Tyr Leu Gly 
        35                  40                  45              

Val Leu Thr Thr Lys Ser Gln Arg Leu Ser Trp Leu Tyr Trp Gly Leu 
    50                  55                  60                  

Met Leu Thr Tyr Val Val Gly Asn Thr Ala Phe Val Ala Val Asn Tyr 
65                  70                  75                  80  

Ile Trp Phe Phe Phe Phe Leu Ser Asn Leu Leu Ser Tyr His Phe Ser 
                85                  90                  95      

Val Arg Ser Leu Lys Ser Leu His Val Trp Thr Phe Leu Leu Ala Gln 
            100                 105                 110         

Val Leu Val Val Gly Gln Leu Leu Ile Phe Gln Arg Ile Glu Val Glu 
        115                 120                 125             

Phe Leu Phe Tyr Leu Leu Val Ile Leu Thr Phe Val Asp Leu Met Thr 
    130                 135                 140                 

Phe Gly Leu Val Arg Ile Arg Ile Val Glu Asp Leu Lys Glu Ala Gln 
145                 150                 155                 160 

Val Lys Gln Asn Ala Gln Ile Asn Leu Leu Leu Ala Glu Asn Glu Arg 
                165                 170                 175     

Ser Arg Ile Gly Gln Asp Leu His Asp Ser Leu Gly His Thr Phe Ala 
            180                 185                 190         

Met Leu Ser Val Lys Thr Asp Leu Ala Leu Gln Leu Phe Gln Met Glu 
        195                 200                 205             

Ala Tyr Pro Gln Val Glu Lys Glu Leu Lys Glu Ile His Gln Ile Ser 
    210                 215                 220                 

Lys Asp Ser Met Asn Glu Val Arg Thr Ile Val Glu Asn Leu Lys Ser 
225                 230                 235                 240 

Arg Thr Leu Thr Ser Glu Leu Glu Thr Val Lys Lys Met Leu Glu Ile 
                245                 250                 255     

Ala Gly Ile Glu Val Gln Val Glu Asn His Leu Asp Lys Ser Ser Leu 
            260                 265                 270         

Thr Gln Glu Leu Glu Ser Thr Ala Ser Met Ile Leu Leu Glu Leu Val 
        275                 280                 285             

Thr Asn Ile Ile Lys His Ala Lys Ala Ser Lys Val Tyr Leu Lys Leu 
    290                 295                 300                 

Glu Arg Thr Glu Lys Glu Leu Ile Leu Thr Val Arg Asp Asp Gly Cys 
305                 310                 315                 320 

Gly Phe Ala Ser Ile Ser Gly Asp Glu Leu His Thr Val Arg Asn Arg 
                325                 330                 335     

Val Phe Pro Phe Ser Gly Glu Val Ser Val Ile Ser Gln Lys His Pro 
            340                 345                 350         

Thr Glu Val Gln Val Arg Leu Leu Tyr Lys Glu Arg Lys 
        355                 360                 365 

<210>   4169
<211>   735
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4169
atgaaacgat ggctagcact tagtaagata gaatttttat tgaccaaacg acaattgatc   60
tattatctat tgtcagtagg gatgccgacg gctttctatt tatttttttc tggtatctat   120
caggacacac caggtgaact cgcgaatttt atgcgtgatt atcttatctc catgactgca   180
ttttccatga tgtcaacagc tatcttctca ttcccagttg ttttacatac cgacaagatc   240
aacaactggc agaaaacatt gcgtcatagc cctgtaaata tggtagaata ttatctatca   300
aagataacaa gtatgctggt tgattatttg gtttcaatct tggtggtttt ctcagttggg   360
cattttgtaa gaggtgtgga catgtctctt ggaaattgga ttggggctgc acttttgctg   420
atagtaggaa gtattgcctt cgtagcgctt ggtttgacct tgactctctt accaactagt   480
cagttgatgt ctgtcgtggg caatcttctt tatctagggt tggctgtttt aggtggactc   540
tggatgccta tctctttatt tccagactgg atgcaagtag taggtaagtg tctcccgacc   600
tatcagttga tggagttgct caagaccttc ttaaatgagg gtggcatcaa tctatcagcc   660
acagtttatt tacttgtttt ttcagtagtt ttgtttggtt tgaccattta ccttcaaggt   720
cataaggaga atgct                                                    735

<210>   4170
<211>   245
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903858 (e-138)

<400>   4170
Met Lys Arg Trp Leu Ala Leu Ser Lys Ile Glu Phe Leu Leu Thr Lys 
1               5                   10                  15      

Arg Gln Leu Ile Tyr Tyr Leu Leu Ser Val Gly Met Pro Thr Ala Phe 
            20                  25                  30          

Tyr Leu Phe Phe Ser Gly Ile Tyr Gln Asp Thr Pro Gly Glu Leu Ala 
        35                  40                  45              

Asn Phe Met Arg Asp Tyr Leu Ile Ser Met Thr Ala Phe Ser Met Met 
    50                  55                  60                  

Ser Thr Ala Ile Phe Ser Phe Pro Val Val Leu His Thr Asp Lys Ile 
65                  70                  75                  80  

Asn Asn Trp Gln Lys Thr Leu Arg His Ser Pro Val Asn Met Val Glu 
                85                  90                  95      

Tyr Tyr Leu Ser Lys Ile Thr Ser Met Leu Val Asp Tyr Leu Val Ser 
            100                 105                 110         

Ile Leu Val Val Phe Ser Val Gly His Phe Val Arg Gly Val Asp Met 
        115                 120                 125             

Ser Leu Gly Asn Trp Ile Gly Ala Ala Leu Leu Leu Ile Val Gly Ser 
    130                 135                 140                 

Ile Ala Phe Val Ala Leu Gly Leu Thr Leu Thr Leu Leu Pro Thr Ser 
145                 150                 155                 160 

Gln Leu Met Ser Val Val Gly Asn Leu Leu Tyr Leu Gly Leu Ala Val 
                165                 170                 175     

Leu Gly Gly Leu Trp Met Pro Ile Ser Leu Phe Pro Asp Trp Met Gln 
            180                 185                 190         

Val Val Gly Lys Cys Leu Pro Thr Tyr Gln Leu Met Glu Leu Leu Lys 
        195                 200                 205             

Thr Phe Leu Asn Glu Gly Gly Ile Asn Leu Ser Ala Thr Val Tyr Leu 
    210                 215                 220                 

Leu Val Phe Ser Val Val Leu Phe Gly Leu Thr Ile Tyr Leu Gln Gly 
225                 230                 235                 240 

His Lys Glu Asn Ala 
                245 

<210>   4171
<211>   882
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4171
atgaatatga ttaaggtaga aagcctaaat aaaaacatca agggcaaggc tattttgaag   60
ggtatttcct ttgaggtagc tgaaggtgaa tgcgtcgcct tgattgggcc caatggtgct   120
gggaagacca cactcttgga ctgtctgctt ggagataaac tggtcacaag cggtcaagta   180
tccatccaag gcttgtcagt gacgagttct cagttagact atattagagg ttatctgcct   240
caagaaaatg tcatcgttca gaaattaaag gtcaaagagt tgattgcttt ctttcaacgt   300
atctatccaa attccttgag cgatcaggaa atcgatcaac tattgcagtt tgaccagcaa   360
caaaaagagc aattcgcaga aaaattgtca ggcgggcaaa agcgtctctt ctcttttgtc   420
ttgaccttga ttgggcgacc aaagcttgtc tttttagatg aaccaactgc tgccatggat   480
acttcaactc gtcaacgctt ttgggaaatc gttcgggacc taaaagcgca aggagtcacg   540
attctctatt cgtctcatta tattgaagag gtagagcata cggctgaccg gattttggtt   600
ttaaataagg gagagttgat tcgtgatacg acgcctctag ctatgcgtag tgagggaatt   660
gaaaagcatt ttatccttcc tctggcatac aaggaagtca ttgagcagtc taacttggtt   720
gaaaactggt cacaaaaaca ggatgctcta caagtagtca cacgcgaagc agatgctttt   780
tgggaactgt tagttcaagc aggatgtggc atacaagaaa ttgaagttaa taatcgtagt   840
ttgttggata caatctttga agaaacgcag aagggagata ac                      882

<210>   4172
<211>   294
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903859 (e-146)

<400>   4172
Met Asn Met Ile Lys Val Glu Ser Leu Asn Lys Asn Ile Lys Gly Lys 
1               5                   10                  15      

Ala Ile Leu Lys Gly Ile Ser Phe Glu Val Ala Glu Gly Glu Cys Val 
            20                  25                  30          

Ala Leu Ile Gly Pro Asn Gly Ala Gly Lys Thr Thr Leu Leu Asp Cys 
        35                  40                  45              

Leu Leu Gly Asp Lys Leu Val Thr Ser Gly Gln Val Ser Ile Gln Gly 
    50                  55                  60                  

Leu Ser Val Thr Ser Ser Gln Leu Asp Tyr Ile Arg Gly Tyr Leu Pro 
65                  70                  75                  80  

Gln Glu Asn Val Ile Val Gln Lys Leu Lys Val Lys Glu Leu Ile Ala 
                85                  90                  95      

Phe Phe Gln Arg Ile Tyr Pro Asn Ser Leu Ser Asp Gln Glu Ile Asp 
            100                 105                 110         

Gln Leu Leu Gln Phe Asp Gln Gln Gln Lys Glu Gln Phe Ala Glu Lys 
        115                 120                 125             

Leu Ser Gly Gly Gln Lys Arg Leu Phe Ser Phe Val Leu Thr Leu Ile 
    130                 135                 140                 


Gly Arg Pro Lys Leu Val Phe Leu Asp Glu Pro Thr Ala Ala Met Asp 
145                 150                 155                 160 

Thr Ser Thr Arg Gln Arg Phe Trp Glu Ile Val Arg Asp Leu Lys Ala 
                165                 170                 175     

Gln Gly Val Thr Ile Leu Tyr Ser Ser His Tyr Ile Glu Glu Val Glu 
            180                 185                 190         

His Thr Ala Asp Arg Ile Leu Val Leu Asn Lys Gly Glu Leu Ile Arg 
        195                 200                 205             

Asp Thr Thr Pro Leu Ala Met Arg Ser Glu Gly Ile Glu Lys His Phe 
    210                 215                 220                 

Ile Leu Pro Leu Ala Tyr Lys Glu Val Ile Glu Gln Ser Asn Leu Val 
225                 230                 235                 240 

Glu Asn Trp Ser Gln Lys Gln Asp Ala Leu Gln Val Val Thr Arg Glu 
                245                 250                 255     

Ala Asp Ala Phe Trp Glu Leu Leu Val Gln Ala Gly Cys Gly Ile Gln 
            260                 265                 270         

Glu Ile Glu Val Asn Asn Arg Ser Leu Leu Asp Thr Ile Phe Glu Glu 
        275                 280                 285             

Thr Gln Lys Gly Asp Asn 
    290                 

<210>   4173
<211>   192
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4173
atgaagagag ggatcatcta tttctttatc ggcctgtcac tcttggtatg gttagtggaa   60
atgtttacag gttggtttga ccaaaccttg cttcgccaat tcattcgtgg tgctttgggg   120
tttggattta tgattttcgt cgttttcctt atgagaatgg agtggttgaa aggagaatat   180
catgaatatg at                                                       192

<210>   4174
<211>   64
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside

<400>   4174
Met Lys Arg Gly Ile Ile Tyr Phe Phe Ile Gly Leu Ser Leu Leu Val 
1               5                   10                  15      

Trp Leu Val Glu Met Phe Thr Gly Trp Phe Asp Gln Thr Leu Leu Arg 
            20                  25                  30          

Gln Phe Ile Arg Gly Ala Leu Gly Phe Gly Phe Met Ile Phe Val Val 
        35                  40                  45              

Phe Leu Met Arg Met Glu Trp Leu Lys Gly Glu Tyr His Glu Tyr Asp 
    50                  55                  60                  


<210>   4175
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4175
atgttttcgg gattggatga gagtttctat cattttcctt gggagctctt tgctggcttt   60
ggaatgatgt cttggcttgt tagagaaggt ttgaaattag tcggagatgt gaaaaaggag   120
cttgaggaa                                                           129

<210>   4176
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903860 (7.E-19)

<400>   4176
Met Phe Ser Gly Leu Asp Glu Ser Phe Tyr His Phe Pro Trp Glu Leu 
1               5                   10                  15      

Phe Ala Gly Phe Gly Met Met Ser Trp Leu Val Arg Glu Gly Leu Lys 
            20                  25                  30          

Leu Val Gly Asp Val Lys Lys Glu Leu Glu Glu 
        35                  40              

<210>   4177
<211>   477
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4177
atgattaaag aattgtatga agaagtccaa gggactgtgt ataagtgtag aaatgaatat   60
taccttcatt tatgggaatt gtcggattgg gagcaagaag gcatgctctg cttacatgaa   120
ttgattagta gagaagaagg actggtagac gatattccac gtttaaggaa atatttcaag   180
accaagtttc gaaatcgaat tttagactat atccgtaaac aggaaagtca gaagcgtaga   240
tacgataaag aaccctatga agaagtgggt gagatcagtc atcgtataag tgaggggggt   300
ctctggctag atgattatta tctctttcat gaaacactaa gagattatag aaacaaacaa   360
agtaaagaga aacaagaaga actagaacgc gtcttaagca atgaacgatt tcgagggcgt   420
caaagagtat taagagactt acgcattgtg tttaaggagt ttactatccg tacccac      477

<210>   4178
<211>   159
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator ComX1 (comX1)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903861 (3.E-92)

<400>   4178
Met Ile Lys Glu Leu Tyr Glu Glu Val Gln Gly Thr Val Tyr Lys Cys 
1               5                   10                  15      

Arg Asn Glu Tyr Tyr Leu His Leu Trp Glu Leu Ser Asp Trp Glu Gln 
            20                  25                  30          

Glu Gly Met Leu Cys Leu His Glu Leu Ile Ser Arg Glu Glu Gly Leu 
        35                  40                  45              

Val Asp Asp Ile Pro Arg Leu Arg Lys Tyr Phe Lys Thr Lys Phe Arg 
    50                  55                  60                  

Asn Arg Ile Leu Asp Tyr Ile Arg Lys Gln Glu Ser Gln Lys Arg Arg 
65                  70                  75                  80  

Tyr Asp Lys Glu Pro Tyr Glu Glu Val Gly Glu Ile Ser His Arg Ile 
                85                  90                  95      

Ser Glu Gly Gly Leu Trp Leu Asp Asp Tyr Tyr Leu Phe His Glu Thr 
            100                 105                 110         

Leu Arg Asp Tyr Arg Asn Lys Gln Ser Lys Glu Lys Gln Glu Glu Leu 
        115                 120                 125             

Glu Arg Val Leu Ser Asn Glu Arg Phe Arg Gly Arg Gln Arg Val Leu 
    130                 135                 140                 

Arg Asp Leu Arg Ile Val Phe Lys Glu Phe Thr Ile Arg Thr His 
145                 150                 155                 

<210>   4179
<211>   534
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4179
atggatagtt ttgataaagg gtggtttgtt ttacaaactt attctggtta tgaaaataag   60
gtgaaagaaa atctattaca acgtgcacaa acctacaata tgttggataa tattctacgc   120
gttgaaattc caacacaaac agtgcaagtt gaaaaaaatg gaaagagaaa agaagtagaa   180
gaaaatcgct ttccaggtta tgttcttgta gaaatggtca tgacagatga agcttggttt   240
gttgttcgaa acacaccaaa tgttacagga tttgtcggat cacacgggaa cagatcaaaa   300
ccaactccat tattggaaca agaaattcgc gacattttgg tatctatggg acaaactgtt   360
caagaatttg atttcgatgt tgagattggt caaactgtac gtattattga tggtgctttt   420
gcagactaca ctggtaagat tacagaaatt gataataaca aagtgaaaat gattatctct   480
atgtttggta atgacacagt tgcagaagta aatctaaacc aaatcgcaga atta         534

<210>   4180
<211>   178
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcription antitermination protein NusG (nusG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903862 (e-100)

<400>   4180
Met Asp Ser Phe Asp Lys Gly Trp Phe Val Leu Gln Thr Tyr Ser Gly 
1               5                   10                  15      

Tyr Glu Asn Lys Val Lys Glu Asn Leu Leu Gln Arg Ala Gln Thr Tyr 
            20                  25                  30          

Asn Met Leu Asp Asn Ile Leu Arg Val Glu Ile Pro Thr Gln Thr Val 
        35                  40                  45              

Gln Val Glu Lys Asn Gly Lys Arg Lys Glu Val Glu Glu Asn Arg Phe 
    50                  55                  60                  

Pro Gly Tyr Val Leu Val Glu Met Val Met Thr Asp Glu Ala Trp Phe 
65                  70                  75                  80  

Val Val Arg Asn Thr Pro Asn Val Thr Gly Phe Val Gly Ser His Gly 
                85                  90                  95      

Asn Arg Ser Lys Pro Thr Pro Leu Leu Glu Gln Glu Ile Arg Asp Ile 
            100                 105                 110         

Leu Val Ser Met Gly Gln Thr Val Gln Glu Phe Asp Phe Asp Val Glu 
        115                 120                 125             

Ile Gly Gln Thr Val Arg Ile Ile Asp Gly Ala Phe Ala Asp Tyr Thr 
    130                 135                 140                 

Gly Lys Ile Thr Glu Ile Asp Asn Asn Lys Val Lys Met Ile Ile Ser 
145                 150                 155                 160 

Met Phe Gly Asn Asp Thr Val Ala Glu Val Asn Leu Asn Gln Ile Ala 
                165                 170                 175     

Glu Leu 
        

<210>   4181
<211>   174
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4181
atgcgtttta ttggagatat ttttagactt cttaaagaca caacatggcc aactcgcaag   60
gaaagctgga gagattttcg ttctatcatg gaatacacag ctttctttgt agtaattatt   120
tacatttttg accagttgat tgtttcaggt ttgattcgat ttattaacat tttt         174

<210>   4182
<211>   58
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   preprotein translocase, SecE subunit, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903863 (6.E-30)

<400>   4182
Met Arg Phe Ile Gly Asp Ile Phe Arg Leu Leu Lys Asp Thr Thr Trp 
1               5                   10                  15      

Pro Thr Arg Lys Glu Ser Trp Arg Asp Phe Arg Ser Ile Met Glu Tyr 
            20                  25                  30          

Thr Ala Phe Phe Val Val Ile Ile Tyr Ile Phe Asp Gln Leu Ile Val 
        35                  40                  45              

Ser Gly Leu Ile Arg Phe Ile Asn Ile Phe 
    50                  55              

<210>   4183
<211>   2193
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4183
atgaaattag ataaattatt tgagaaattt ctttctcttt ttaaaaaaga aacaagtgaa   60
ctagaggact ctgattctac tatcttacgt cgctctcgta gtgatcgaaa aaaattagcc   120
caagtaggtc cgattcgaaa attctggcgt cgttatcatc taacaaagat tatccttata   180
ctaggtttga gtgcaggctt gctagttgga atctatttgt ttgctgtagc caagtcgacc   240
aatgtcaatg atttgcaaaa tgccttgaaa actcggactc ttatttttga ccgtgaagaa   300
aaagaggctg gtgccttgtc tggtcaaaag ggaacctatg ttgagctgac tgacatcagt   360
aaaaacttgc agaatgctgt tattgcgaca gaagaccgtt ctttctataa aaatgacggg   420
attaactatg gccgtttttt cttggctatt gtcactgctg gacgttcagg tggtggctct   480
accattaccc aacagctggc taaaaacgcc tatttatcgc aggatcaaac tgttgagaga   540
aaagcgaaag aatttttcct tgccttagaa ttaagcaaaa aatatagtaa ggagcaaatt   600
ctaaccatgt accttaacaa cgcttatttt ggaaatggtg tgtggggtgt agaagatgcg   660
agtaagaaat actttggagt ttctgcatca gaagtgagtc tggatcaagc tgcgactctg   720
gcagggatgc tcaaggggcc ggaactgtat aatcccttga attccgtaga agattctact   780
aatcggcgcg atactgtctt gcagaatatg gttgcagcag gatatattga taaaaaccaa   840
gaaaccaaag ctgctgaagt tgatatgact tcgcaattgc acgataagta tgaaggaaaa   900
atctcagatt accgttaccc ctcttatttt gatgcggtgg ttaatgaagc tgtttccaag   960
tataatctaa cagaggaaga gattgtcaat aatggctacc gcatttacac agagctggac   1020
caaaactacc aagcaaatat gcagattgtt tatgaaaaca catcgctatt tccgagggca   1080
gaggatggaa cgtttgctca atcaggaagt gtagccctcg aaccgaaaac agggggagtt   1140
cgtggagttg tcggtcaagt tgctgacaat gataaaactg gattccggaa tttcaactat   1200
gcaacccaat caaagcgtag tcctggttct acaattaagc ctttagttgt ttatacgcca   1260
gcagttgaag caagctgggc tttgaataag cagttggata accataccat gcagtatgac   1320
agctataagg ttgataacta tgcagggatc aaaacgagtc gagaagttcc tatgtatcaa   1380
gccttggcag aatcgcttaa tctacctgct gttgccactg ttaatgattt gggtgtcgac   1440
aaggcttttg aggcaggcga aaaattcgga ctcaacatgg aaaaggtcga ccgtgttctt   1500
ggtgtcgcct tgggaagcgg tgttgaaacc aaccctcttc aaatggctca agcatacgcc   1560
gcctttgcaa atgaaggttt aatgcctgaa gctcatttta ttagtagaat tgaaaatgct   1620
agtggacaag ttattgcgag tcataaaaat tcacaaaaac gggtgattga taagtctgta   1680
gctgacaaga tgaccagtat gatgttgggg actttcacca acggtaccgg tattagttca   1740
tcgcctgcag actatgtcat ggcagggaaa actggaacaa ctgaagcagt tttcaatccg   1800
gagtacacaa gtgaccagtg ggtaattggt tatactccgg atgtagtgat tagccactgg   1860
cttggctttc cgaccactga tgaaaaccac tatctagctg gctctacttc aaacggtgca   1920
gctcatgtct ttagaaacat tgccaatacc attttacctt atacgccagg aagtaccttt   1980
acggttgaaa atgcttataa gcaaaatgga attgcaccag ccaatacaaa aagacaagta   2040
caaaccaatg ataatagcca gacagatgat aatttgtctg atattcgagg gcgtgcgcaa   2100
agtctagtag atgaggctag ccgggctatc tcagatgcga agattaagga aaaggctcaa   2160
acaatatggg attcgatagt caatctattt cgc                                2193

<210>   4184
<211>   731
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   penicillin-binding protein 2A (pbp2A)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903865 (0.E+01)

<400>   4184
Met Lys Leu Asp Lys Leu Phe Glu Lys Phe Leu Ser Leu Phe Lys Lys 
1               5                   10                  15      

Glu Thr Ser Glu Leu Glu Asp Ser Asp Ser Thr Ile Leu Arg Arg Ser 
            20                  25                  30          

Arg Ser Asp Arg Lys Lys Leu Ala Gln Val Gly Pro Ile Arg Lys Phe 
        35                  40                  45              

Trp Arg Arg Tyr His Leu Thr Lys Ile Ile Leu Ile Leu Gly Leu Ser 
    50                  55                  60                  

Ala Gly Leu Leu Val Gly Ile Tyr Leu Phe Ala Val Ala Lys Ser Thr 
65                  70                  75                  80  

Asn Val Asn Asp Leu Gln Asn Ala Leu Lys Thr Arg Thr Leu Ile Phe 
                85                  90                  95      

Asp Arg Glu Glu Lys Glu Ala Gly Ala Leu Ser Gly Gln Lys Gly Thr 
            100                 105                 110         

Tyr Val Glu Leu Thr Asp Ile Ser Lys Asn Leu Gln Asn Ala Val Ile 
        115                 120                 125             

Ala Thr Glu Asp Arg Ser Phe Tyr Lys Asn Asp Gly Ile Asn Tyr Gly 
    130                 135                 140                 

Arg Phe Phe Leu Ala Ile Val Thr Ala Gly Arg Ser Gly Gly Gly Ser 
145                 150                 155                 160 

Thr Ile Thr Gln Gln Leu Ala Lys Asn Ala Tyr Leu Ser Gln Asp Gln 
                165                 170                 175     

Thr Val Glu Arg Lys Ala Lys Glu Phe Phe Leu Ala Leu Glu Leu Ser 
            180                 185                 190         

Lys Lys Tyr Ser Lys Glu Gln Ile Leu Thr Met Tyr Leu Asn Asn Ala 
        195                 200                 205             

Tyr Phe Gly Asn Gly Val Trp Gly Val Glu Asp Ala Ser Lys Lys Tyr 
    210                 215                 220                 

Phe Gly Val Ser Ala Ser Glu Val Ser Leu Asp Gln Ala Ala Thr Leu 
225                 230                 235                 240 

Ala Gly Met Leu Lys Gly Pro Glu Leu Tyr Asn Pro Leu Asn Ser Val 
                245                 250                 255     

Glu Asp Ser Thr Asn Arg Arg Asp Thr Val Leu Gln Asn Met Val Ala 
            260                 265                 270         

Ala Gly Tyr Ile Asp Lys Asn Gln Glu Thr Lys Ala Ala Glu Val Asp 
        275                 280                 285             

Met Thr Ser Gln Leu His Asp Lys Tyr Glu Gly Lys Ile Ser Asp Tyr 
    290                 295                 300                 

Arg Tyr Pro Ser Tyr Phe Asp Ala Val Val Asn Glu Ala Val Ser Lys 
305                 310                 315                 320 

Tyr Asn Leu Thr Glu Glu Glu Ile Val Asn Asn Gly Tyr Arg Ile Tyr 
                325                 330                 335     

Thr Glu Leu Asp Gln Asn Tyr Gln Ala Asn Met Gln Ile Val Tyr Glu 
            340                 345                 350         

Asn Thr Ser Leu Phe Pro Arg Ala Glu Asp Gly Thr Phe Ala Gln Ser 
        355                 360                 365             

Gly Ser Val Ala Leu Glu Pro Lys Thr Gly Gly Val Arg Gly Val Val 
    370                 375                 380                 

Gly Gln Val Ala Asp Asn Asp Lys Thr Gly Phe Arg Asn Phe Asn Tyr 
385                 390                 395                 400 

Ala Thr Gln Ser Lys Arg Ser Pro Gly Ser Thr Ile Lys Pro Leu Val 
                405                 410                 415     

Val Tyr Thr Pro Ala Val Glu Ala Ser Trp Ala Leu Asn Lys Gln Leu 
            420                 425                 430         

Asp Asn His Thr Met Gln Tyr Asp Ser Tyr Lys Val Asp Asn Tyr Ala 
        435                 440                 445             

Gly Ile Lys Thr Ser Arg Glu Val Pro Met Tyr Gln Ala Leu Ala Glu 
    450                 455                 460                 

Ser Leu Asn Leu Pro Ala Val Ala Thr Val Asn Asp Leu Gly Val Asp 
465                 470                 475                 480 

Lys Ala Phe Glu Ala Gly Glu Lys Phe Gly Leu Asn Met Glu Lys Val 
                485                 490                 495     

Asp Arg Val Leu Gly Val Ala Leu Gly Ser Gly Val Glu Thr Asn Pro 
            500                 505                 510         

Leu Gln Met Ala Gln Ala Tyr Ala Ala Phe Ala Asn Glu Gly Leu Met 
        515                 520                 525             

Pro Glu Ala His Phe Ile Ser Arg Ile Glu Asn Ala Ser Gly Gln Val 
    530                 535                 540                 

Ile Ala Ser His Lys Asn Ser Gln Lys Arg Val Ile Asp Lys Ser Val 
545                 550                 555                 560 

Ala Asp Lys Met Thr Ser Met Met Leu Gly Thr Phe Thr Asn Gly Thr 
                565                 570                 575     

Gly Ile Ser Ser Ser Pro Ala Asp Tyr Val Met Ala Gly Lys Thr Gly 
            580                 585                 590         

Thr Thr Glu Ala Val Phe Asn Pro Glu Tyr Thr Ser Asp Gln Trp Val 
        595                 600                 605             

Ile Gly Tyr Thr Pro Asp Val Val Ile Ser His Trp Leu Gly Phe Pro 
    610                 615                 620                 

Thr Thr Asp Glu Asn His Tyr Leu Ala Gly Ser Thr Ser Asn Gly Ala 
625                 630                 635                 640 

Ala His Val Phe Arg Asn Ile Ala Asn Thr Ile Leu Pro Tyr Thr Pro 
                645                 650                 655     

Gly Ser Thr Phe Thr Val Glu Asn Ala Tyr Lys Gln Asn Gly Ile Ala 
            660                 665                 670         

Pro Ala Asn Thr Lys Arg Gln Val Gln Thr Asn Asp Asn Ser Gln Thr 
        675                 680                 685             

Asp Asp Asn Leu Ser Asp Ile Arg Gly Arg Ala Gln Ser Leu Val Asp 

    690                 695                 700                 

Glu Ala Ser Arg Ala Ile Ser Asp Ala Lys Ile Lys Glu Lys Ala Gln 
705                 710                 715                 720 

Thr Ile Trp Asp Ser Ile Val Asn Leu Phe Arg 
                725                 730     

<210>   4185
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4185
atgcaattca catttacatt acccgcctct ctacctcaaa tgacagtaaa gcaattactt   60
gaggaacaac tcctcatccc tagaaaaatc cgtcattttt tgagaatcaa gaaacatatt   120
ttgataaatc aagaagaagt ccactggaag gaaatcgtaa atcctggaga tgtttgccag   180
ttgacttttg acgaggaaga ttattcccaa aagacgatcc cttggggcaa cccagactta   240
gtgcaggaag tttatcaaga tcaacacttg attattgtaa acaaaccaga ggggatgaaa   300
acgcatggta atcaaccaaa cgaaattgcc cttcttaacc atgtcagtac ctatgttggc   360
caaacctgct atgtcgttca tcgtctggac atggaaacca gtggcttagt tctctttgcc   420
aaaaatcctt ttatcctgcc cattctcaat cgcttattgg agaaaaaaga gatttctaga   480
gaatattggg ctctagttga tggaaatatc aacagaaaag aacttgtttt cagagacaaa   540
attggacgtg atcgccatga tcgtagaaaa agaatagttg atgcaaaaaa tgggcaatat   600
gctgaaacgc atgtaagcag attaaagcaa ttctcaaaca agacttcctt ggctcattgc   660
aagctaaaga cagggcgaac ccatcagatt cgtgtgcacc tttcgcatca taatcttcct   720
atcctgggag accctctcta taatagtaaa tcaaagacaa gccggcttat gcttcatgcc   780
ttccgacttt cctttaccca cccacttact ttagagaagc taactttcac taccctttca   840
aatacatttg aaaaagaatt aaaaaagaat gga                                873

<210>   4186
<211>   291
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal large subunit pseudouridine synthase, RluD subfamily
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903866 (e-168)

<400>   4186
Met Gln Phe Thr Phe Thr Leu Pro Ala Ser Leu Pro Gln Met Thr Val 
1               5                   10                  15      

Lys Gln Leu Leu Glu Glu Gln Leu Leu Ile Pro Arg Lys Ile Arg His 
            20                  25                  30          

Phe Leu Arg Ile Lys Lys His Ile Leu Ile Asn Gln Glu Glu Val His 
        35                  40                  45              

Trp Lys Glu Ile Val Asn Pro Gly Asp Val Cys Gln Leu Thr Phe Asp 
    50                  55                  60                  

Glu Glu Asp Tyr Ser Gln Lys Thr Ile Pro Trp Gly Asn Pro Asp Leu 
65                  70                  75                  80  

Val Gln Glu Val Tyr Gln Asp Gln His Leu Ile Ile Val Asn Lys Pro 
                85                  90                  95      

Glu Gly Met Lys Thr His Gly Asn Gln Pro Asn Glu Ile Ala Leu Leu 
            100                 105                 110         

Asn His Val Ser Thr Tyr Val Gly Gln Thr Cys Tyr Val Val His Arg 
        115                 120                 125             

Leu Asp Met Glu Thr Ser Gly Leu Val Leu Phe Ala Lys Asn Pro Phe 
    130                 135                 140                 

Ile Leu Pro Ile Leu Asn Arg Leu Leu Glu Lys Lys Glu Ile Ser Arg 
145                 150                 155                 160 

Glu Tyr Trp Ala Leu Val Asp Gly Asn Ile Asn Arg Lys Glu Leu Val 
                165                 170                 175     

Phe Arg Asp Lys Ile Gly Arg Asp Arg His Asp Arg Arg Lys Arg Ile 
            180                 185                 190         

Val Asp Ala Lys Asn Gly Gln Tyr Ala Glu Thr His Val Ser Arg Leu 
        195                 200                 205             

Lys Gln Phe Ser Asn Lys Thr Ser Leu Ala His Cys Lys Leu Lys Thr 
    210                 215                 220                 

Gly Arg Thr His Gln Ile Arg Val His Leu Ser His His Asn Leu Pro 
225                 230                 235                 240 

Ile Leu Gly Asp Pro Leu Tyr Asn Ser Lys Ser Lys Thr Ser Arg Leu 
                245                 250                 255     

Met Leu His Ala Phe Arg Leu Ser Phe Thr His Pro Leu Thr Leu Glu 
            260                 265                 270         

Lys Leu Thr Phe Thr Thr Leu Ser Asn Thr Phe Glu Lys Glu Leu Lys 
        275                 280                 285             

Lys Asn Gly 
    290     

<210>   4187
<211>   1005
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4187
atggtagtta aagttggtat taacggtttc ggacgtatcg gtcgtcttgc tttccgtcgt   60
atccaaaacg tagaaggtgt tgaagttaca cgcatcaacg accttacaga tccagttatg   120
cttgcacact tgttgaaata cgacacaact caaggtcgtt tcgacggtac tgttgaagtt   180
aaagaaggtg gatttgaagt taacggtaaa ttcatcaaag tttctgctga acgtgatcca   240
gaacaaatcg actgggctac tgacggtgta gaaatcgttc ttgaagctac tggtttcttt   300
gctaagaaag aagcagctga aaaacacctt aaaggtggag ctaaaaaagt tgttatcact   360
gctcctggtg gaaacgacgt taaaacagtt gtattcaaca ctaaccacga cgttcttgac   420
ggtactgaaa cagttatctc aggtgcttca tgtactacaa actgcttggc tccaatggct   480
aaagctcttc aagacaactt tggtgttgtt gaaggattga tgactactat ccacgcttac   540
actggtgacc aaatgatcct tgacggacca caccgtggtg gtgaccttcg ccgtgctcgc   600
gctggtgctg caaacatcgt tcctaactca actggtgctg caaaagctat cggtcttgta   660
atcccagaat tgaatggtaa acttgacgga tctgcacaac gcgttccaac tccaactgga   720
tcagttactg aattggtagc agttcttgaa aagaacgtta ctgttgatga agtgaacgca   780
gctatgaaag cagcttcaaa cgaatcatac ggttacacag aagatccaat cgtatcttca   840
gatatcgtag gtatgtctta cggttcattg tttgacgcaa ctcaaactaa agttcttgac   900
gttgacggta aacaattggt taaagttgta tcatggtacg acaacgaaat gtcatacact   960
gcacaacttg ttcgtactct tgaatacttc gcaaaaattg ctaaa                   1005

<210>   4188
<211>   335
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glyceraldehyde 3-phosphate dehydrogenase (gap)
<223>   Cellular location: cytoplasm
<223>   Feature of note: secreted
<223>   Similar to strain R6 sequence 15903867 (0.E+01)

<400>   4188
Met Val Val Lys Val Gly Ile Asn Gly Phe Gly Arg Ile Gly Arg Leu 
1               5                   10                  15      

Ala Phe Arg Arg Ile Gln Asn Val Glu Gly Val Glu Val Thr Arg Ile 
            20                  25                  30          

Asn Asp Leu Thr Asp Pro Val Met Leu Ala His Leu Leu Lys Tyr Asp 
        35                  40                  45              

Thr Thr Gln Gly Arg Phe Asp Gly Thr Val Glu Val Lys Glu Gly Gly 
    50                  55                  60                  

Phe Glu Val Asn Gly Lys Phe Ile Lys Val Ser Ala Glu Arg Asp Pro 
65                  70                  75                  80  

Glu Gln Ile Asp Trp Ala Thr Asp Gly Val Glu Ile Val Leu Glu Ala 
                85                  90                  95      

Thr Gly Phe Phe Ala Lys Lys Glu Ala Ala Glu Lys His Leu Lys Gly 
            100                 105                 110         

Gly Ala Lys Lys Val Val Ile Thr Ala Pro Gly Gly Asn Asp Val Lys 
        115                 120                 125             


Thr Val Val Phe Asn Thr Asn His Asp Val Leu Asp Gly Thr Glu Thr 
    130                 135                 140                 

Val Ile Ser Gly Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Met Ala 
145                 150                 155                 160 

Lys Ala Leu Gln Asp Asn Phe Gly Val Val Glu Gly Leu Met Thr Thr 
                165                 170                 175     

Ile His Ala Tyr Thr Gly Asp Gln Met Ile Leu Asp Gly Pro His Arg 
            180                 185                 190         

Gly Gly Asp Leu Arg Arg Ala Arg Ala Gly Ala Ala Asn Ile Val Pro 
        195                 200                 205             

Asn Ser Thr Gly Ala Ala Lys Ala Ile Gly Leu Val Ile Pro Glu Leu 
    210                 215                 220                 

Asn Gly Lys Leu Asp Gly Ser Ala Gln Arg Val Pro Thr Pro Thr Gly 
225                 230                 235                 240 

Ser Val Thr Glu Leu Val Ala Val Leu Glu Lys Asn Val Thr Val Asp 
                245                 250                 255     

Glu Val Asn Ala Ala Met Lys Ala Ala Ser Asn Glu Ser Tyr Gly Tyr 
            260                 265                 270         

Thr Glu Asp Pro Ile Val Ser Ser Asp Ile Val Gly Met Ser Tyr Gly 
        275                 280                 285             

Ser Leu Phe Asp Ala Thr Gln Thr Lys Val Leu Asp Val Asp Gly Lys 
    290                 295                 300                 

Gln Leu Val Lys Val Val Ser Trp Tyr Asp Asn Glu Met Ser Tyr Thr 
305                 310                 315                 320 

Ala Gln Leu Val Arg Thr Leu Glu Tyr Phe Ala Lys Ile Ala Lys 
                325                 330                 335 

<210>   4189
<211>   978
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4189
ttggagagtc cttttgggat gaacatgtca aatattacta tagatgggca agaaatggat   60
ctgagtcaaa cgatgccttc ttatgctcaa gtagtgagtc tttatgatga tacaagtatc   120
tctgttagta ataatgagac ggacaaagtg ttggctggat ccctctatac tgatacaaat   180
gaacagggat taacgattcc aagcagttta ctaaaaaatt ggaatgaaca gacaggaaaa   240
aatttgacag ctaatgatct tattggcaaa tcagtctcag ccagcattgt agaaagtgct   300
gccgaaacta gtaagattgc tcaatttcaa acgaagattg tacgtgtaat caatgatgaa   360
gatgacatgg aggacagcaa cagtttcatg ctgtctcatc aaatggaaac gattttgaaa   420
gaggctggat ttacgaaagc tgtatcttat tttatcttgg aactcaaaga tccatcacag   480
acaaaagtag taacagaaga attacagaaa aataagaagt atactgtgct ttctcaacag   540
agagttcttg atattgtgat tacctttatt cgtgttattc agggattatt gattgtgctt   600
tcatcacaag ctattgtggt agcagcggtt atgattggta tcattattta catcaatatc   660
atgcaacgtt ccaaggaaat aggtgtcatg aaagcagttg gttatcagaa tcgtgatgtc   720
aaaggaattt ttatttacga ggctatctgg attgtaggca tcgccttgct gctggcattt   780
ttggttgcac aaggggtggg aagtttggcg aatgcgattg taagtcactt ttacccatcc   840
atcactaagg tttttaaatt aaatctttta tctgttttag gaactctagt tttcgctcta   900
ttacttggtt atgtctcagc ctacttcccg gcgcgtaaga ttagtaaaat ggatcctata   960
gaatcgttat gctatgaa                                                 978

<210>   4190
<211>   326
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903868 (e-176)

<400>   4190
Met Glu Ser Pro Phe Gly Met Asn Met Ser Asn Ile Thr Ile Asp Gly 
1               5                   10                  15      

Gln Glu Met Asp Leu Ser Gln Thr Met Pro Ser Tyr Ala Gln Val Val 
            20                  25                  30          

Ser Leu Tyr Asp Asp Thr Ser Ile Ser Val Ser Asn Asn Glu Thr Asp 
        35                  40                  45              

Lys Val Leu Ala Gly Ser Leu Tyr Thr Asp Thr Asn Glu Gln Gly Leu 
    50                  55                  60                  

Thr Ile Pro Ser Ser Leu Leu Lys Asn Trp Asn Glu Gln Thr Gly Lys 
65                  70                  75                  80  

Asn Leu Thr Ala Asn Asp Leu Ile Gly Lys Ser Val Ser Ala Ser Ile 
                85                  90                  95      

Val Glu Ser Ala Ala Glu Thr Ser Lys Ile Ala Gln Phe Gln Thr Lys 
            100                 105                 110         

Ile Val Arg Val Ile Asn Asp Glu Asp Asp Met Glu Asp Ser Asn Ser 
        115                 120                 125             

Phe Met Leu Ser His Gln Met Glu Thr Ile Leu Lys Glu Ala Gly Phe 
    130                 135                 140                 

Thr Lys Ala Val Ser Tyr Phe Ile Leu Glu Leu Lys Asp Pro Ser Gln 
145                 150                 155                 160 

Thr Lys Val Val Thr Glu Glu Leu Gln Lys Asn Lys Lys Tyr Thr Val 
                165                 170                 175     

Leu Ser Gln Gln Arg Val Leu Asp Ile Val Ile Thr Phe Ile Arg Val 
            180                 185                 190         

Ile Gln Gly Leu Leu Ile Val Leu Ser Ser Gln Ala Ile Val Val Ala 
        195                 200                 205             

Ala Val Met Ile Gly Ile Ile Ile Tyr Ile Asn Ile Met Gln Arg Ser 
    210                 215                 220                 

Lys Glu Ile Gly Val Met Lys Ala Val Gly Tyr Gln Asn Arg Asp Val 
225                 230                 235                 240 

Lys Gly Ile Phe Ile Tyr Glu Ala Ile Trp Ile Val Gly Ile Ala Leu 
                245                 250                 255     

Leu Leu Ala Phe Leu Val Ala Gln Gly Val Gly Ser Leu Ala Asn Ala 
            260                 265                 270         

Ile Val Ser His Phe Tyr Pro Ser Ile Thr Lys Val Phe Lys Leu Asn 
        275                 280                 285             

Leu Leu Ser Val Leu Gly Thr Leu Val Phe Ala Leu Leu Leu Gly Tyr 
    290                 295                 300                 

Val Ser Ala Tyr Phe Pro Ala Arg Lys Ile Ser Lys Met Asp Pro Ile 
305                 310                 315                 320 

Glu Ser Leu Cys Tyr Glu 
                325     

<210>   4191
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4191
atgggctcat atcaaaaagc acctcaaaaa ggtattacca agttgcaata ccttttacga   60
ggctttttta tcctgctctt gtttcaattg actatatatc acggatacag ttgggaaaga   120
agctat                                                              126

<210>   4192
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4192
Met Gly Ser Tyr Gln Lys Ala Pro Gln Lys Gly Ile Thr Lys Leu Gln 
1               5                   10                  15      

Tyr Leu Leu Arg Gly Phe Phe Ile Leu Leu Leu Phe Gln Leu Thr Ile 
            20                  25                  30          

Tyr His Gly Tyr Ser Trp Glu Arg Ser Tyr 
        35                  40          

<210>   4193
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4193
ttggttgcag gtctaacaaa tggtgaatta atcgctccaa tgacttacga agagacgatg   60
acgagcgact tttttgaagc ttggtttcag aattttctct taccaacatt aaacacacca   120
tcggttatta ttatggataa tgtaagattc catagaatgg ggaagctaga acttttatgc   180
gaagagtttg ggcataaact tttacctctt cctccctact cgcctgagta caatcctatt   240
gagaaaacat gggctcatat caaaaagcac ctcaaaaagg tattaccaag ttgcaatacc   300
ttttacgagg cttttttatc ctgctcttgt ttcaat                             336

<210>   4194
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903081 (2.E-63)

<400>   4194
Met Val Ala Gly Leu Thr Asn Gly Glu Leu Ile Ala Pro Met Thr Tyr 
1               5                   10                  15      

Glu Glu Thr Met Thr Ser Asp Phe Phe Glu Ala Trp Phe Gln Asn Phe 
            20                  25                  30          

Leu Leu Pro Thr Leu Asn Thr Pro Ser Val Ile Ile Met Asp Asn Val 
        35                  40                  45              

Arg Phe His Arg Met Gly Lys Leu Glu Leu Leu Cys Glu Glu Phe Gly 
    50                  55                  60                  

His Lys Leu Leu Pro Leu Pro Pro Tyr Ser Pro Glu Tyr Asn Pro Ile 
65                  70                  75                  80  

Glu Lys Thr Trp Ala His Ile Lys Lys His Leu Lys Lys Val Leu Pro 
                85                  90                  95      

Ser Cys Asn Thr Phe Tyr Glu Ala Phe Leu Ser Cys Ser Cys Phe Asn 
            100                 105                 110         


<210>   4195
<211>   414
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4195
atgtggtata atctttttat ggcatattca atagattttc gtaaaaaagt tctctcttat   60
tgtgagcgaa caggtagtat aacagaagca tcacacgttt tccaaatctc acgtaatacc   120
atttatggct ggttaaagct aaaagagaaa acaggagagc taaaccacca agtaaaagga   180
ataaaaccaa gaaaggttga tagagataga cttaaaaact atcttactga caatccagac   240
gcttatttga ctgaaatagc ttctgaattt ggctgtcatc caactaccat ccactatacg   300
ctcaaagcta tgggctacac tcgaaaaaag aaccacacct actatgaaca agacccagaa   360
aaagtagcct tatttcttaa gaattttaat agtttaaagc acctagcacc tgtt         414

<210>   4196
<211>   138
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1 FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903870 (5.E-62)

<400>   4196
Met Trp Tyr Asn Leu Phe Met Ala Tyr Ser Ile Asp Phe Arg Lys Lys 
1               5                   10                  15      

Val Leu Ser Tyr Cys Glu Arg Thr Gly Ser Ile Thr Glu Ala Ser His 
            20                  25                  30          

Val Phe Gln Ile Ser Arg Asn Thr Ile Tyr Gly Trp Leu Lys Leu Lys 
        35                  40                  45              

Glu Lys Thr Gly Glu Leu Asn His Gln Val Lys Gly Ile Lys Pro Arg 
    50                  55                  60                  

Lys Val Asp Arg Asp Arg Leu Lys Asn Tyr Leu Thr Asp Asn Pro Asp 
65                  70                  75                  80  

Ala Tyr Leu Thr Glu Ile Ala Ser Glu Phe Gly Cys His Pro Thr Thr 
                85                  90                  95      

Ile His Tyr Thr Leu Lys Ala Met Gly Tyr Thr Arg Lys Lys Asn His 
            100                 105                 110         

Thr Tyr Tyr Glu Gln Asp Pro Glu Lys Val Ala Leu Phe Leu Lys Asn 
        115                 120                 125             

Phe Asn Ser Leu Lys His Leu Ala Pro Val 
    130                 135             

<210>   4197
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4197
gtgatgtcaa tcatttcaac tgatttaacc ccttttcaaa tagatgatac attgaaagca   60
gccttgcgag aagatgttca ttccgaagat tacagtacca atgccatttt tgatcatcat   120
ggccaagcca aggtgtcgct ttttgccaag gaagctggtg ttttagcggg gctaaccgtt   180
tttcaaaggg tttttaccct atttgatgcc gaggtgacct tccagaatcc tcatcaattt   240
aaggatgggg atcgtttgac tagtggcgat ttggttttag aaatcatagg ctcggtgaga   300
agtctcttaa catgtgaacg cgttgccttg aattttttac aacatttatc agggattgct   360
tcgatgacag ctgcttatgt agaagcctta ggcgatgatt gcattaaggt atttgatact   420
cgaaaaacta ctcctaattt acgtcttttt gagaaatatg ccgtgagagt tggcggtggc   480
tataatcatc gctttaattt atcagatgct atcctgctaa aagacaatca cattgcggca   540
gtaggtagtg ttcaaaaggc aattgctcaa gcgcgtgcct atgccccttt tgtgaaaatg   600
gtcgaggtgg aagtggaaag ccttgctgct gccgaagaag ctgcggcggc gggtgctgat   660
attatcatgt tggataatat gtcattggaa cagattgaac aggccattac cctaattgca   720
ggacgttctc ggattgaatg ttctggaaat attgatatga ccactattag ccgttttcgt   780
ggtttagcga ttgattacgt ctccagtggt agtttaaccc atagtgctaa gagtcttgat   840
ttttccatga aggggttaac ctaccttgat gtc                                873

<210>   4198
<211>   291
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   nicotinate-nucleotide pyrophosphorylase (nadC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903871 (e-161)

<400>   4198
Met Met Ser Ile Ile Ser Thr Asp Leu Thr Pro Phe Gln Ile Asp Asp 
1               5                   10                  15      

Thr Leu Lys Ala Ala Leu Arg Glu Asp Val His Ser Glu Asp Tyr Ser 
            20                  25                  30          

Thr Asn Ala Ile Phe Asp His His Gly Gln Ala Lys Val Ser Leu Phe 
        35                  40                  45              

Ala Lys Glu Ala Gly Val Leu Ala Gly Leu Thr Val Phe Gln Arg Val 
    50                  55                  60                  

Phe Thr Leu Phe Asp Ala Glu Val Thr Phe Gln Asn Pro His Gln Phe 
65                  70                  75                  80  

Lys Asp Gly Asp Arg Leu Thr Ser Gly Asp Leu Val Leu Glu Ile Ile 
                85                  90                  95      

Gly Ser Val Arg Ser Leu Leu Thr Cys Glu Arg Val Ala Leu Asn Phe 
            100                 105                 110         

Leu Gln His Leu Ser Gly Ile Ala Ser Met Thr Ala Ala Tyr Val Glu 
        115                 120                 125             

Ala Leu Gly Asp Asp Cys Ile Lys Val Phe Asp Thr Arg Lys Thr Thr 
    130                 135                 140                 

Pro Asn Leu Arg Leu Phe Glu Lys Tyr Ala Val Arg Val Gly Gly Gly 
145                 150                 155                 160 

Tyr Asn His Arg Phe Asn Leu Ser Asp Ala Ile Leu Leu Lys Asp Asn 
                165                 170                 175     

His Ile Ala Ala Val Gly Ser Val Gln Lys Ala Ile Ala Gln Ala Arg 
            180                 185                 190         

Ala Tyr Ala Pro Phe Val Lys Met Val Glu Val Glu Val Glu Ser Leu 
        195                 200                 205             

Ala Ala Ala Glu Glu Ala Ala Ala Ala Gly Ala Asp Ile Ile Met Leu 
    210                 215                 220                 

Asp Asn Met Ser Leu Glu Gln Ile Glu Gln Ala Ile Thr Leu Ile Ala 
225                 230                 235                 240 

Gly Arg Ser Arg Ile Glu Cys Ser Gly Asn Ile Asp Met Thr Thr Ile 
                245                 250                 255     

Ser Arg Phe Arg Gly Leu Ala Ile Asp Tyr Val Ser Ser Gly Ser Leu 
            260                 265                 270         

Thr His Ser Ala Lys Ser Leu Asp Phe Ser Met Lys Gly Leu Thr Tyr 
        275                 280                 285             

Leu Asp Val 
    290     

<210>   4199
<211>   1308
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4199
atgattcatt taataatgat tagcgccatt gctctagcca ttggaattgg ttaccgcacc   60
aaaatcaata ttggcctgct ggctattgct ttttcttacc tcatcgcaac cactctcatg   120
ggattaagcc ccaaagaact tcttcatttt tggccaacct cactcttttt taccattttt   180
agcgtctctc tcttttataa cgttgcaaca actaacggta ctcttgatgt tttggctcaa   240
cacattctct accgcacacg cacccaccct aacgccctct acatgatttt atacctgatg   300
gcaacccttt tgtctgcttt aggtgctgga tttttcacta ctatggccgt ttgctgtcct   360
ctagcgatta ccctctgtca aaaagcggac aaacaccctt tgattggagc tcaagccgtc   420
aattggggag cttcaggagg ggctaatttg ataaccagta gctcaggcat tgtctttcaa   480
ggcctgttta agcaaatggg atgggaagag caagcttttt cacttggcaa tcatatcttt   540
atcgtcagca ttatctaccc actcatcgtc ttgcttttat tatcctgtta cagtcactat   600

agtaagggaa gaacaaactc atccttgact attgaccaac caccactcct cagcaaggtt   660
caaagacaaa ccaccttgct catgatcagc agcatggttt tggtttggct ttttcccttg   720
ttgcatctca ttttcccaaa catcgcctgg atagctactt atcaaaaaac atttgatatt   780
ggctttgtct caatactcat ggtctgcctc gccttaaggc tcaaattagg gaagcaagaa   840
gccattttag ctaaggttcc ctgggctaca attatcatgc tctgcggcat gagcttacta   900
atgtctctag cggtcaagtc aggtttagtc acactgatag ggcacctcat gacaacaacc   960
attcctcatt tctggttacc tctgttcttt tgtgtgatag ccggagtgat gtcactcttt   1020

agttccaccc tatccgttgt agctccagcc ctctttccca tcattgctat catcagtgct   1080
caaaatcctc agattgatat tcacttactc acaacagcca ccgttattgg cgctctatct   1140
actaatatct cacccttttc atcagctggt tctctcattc aactctcact tcccaatata   1200
gaggaacgtg gccttgcctt caaaaagcaa attattctgg gtgtccccat cagcttaagt   1260
ttgggactct tgaccacctg gattctcatc cttctagctt ccttaagt                1308

<210>   4200
<211>   436
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903872 (0.E+01)

<400>   4200
Met Ile His Leu Ile Met Ile Ser Ala Ile Ala Leu Ala Ile Gly Ile 
1               5                   10                  15      

Gly Tyr Arg Thr Lys Ile Asn Ile Gly Leu Leu Ala Ile Ala Phe Ser 
            20                  25                  30          

Tyr Leu Ile Ala Thr Thr Leu Met Gly Leu Ser Pro Lys Glu Leu Leu 
        35                  40                  45              

His Phe Trp Pro Thr Ser Leu Phe Phe Thr Ile Phe Ser Val Ser Leu 
    50                  55                  60                  

Phe Tyr Asn Val Ala Thr Thr Asn Gly Thr Leu Asp Val Leu Ala Gln 
65                  70                  75                  80  

His Ile Leu Tyr Arg Thr Arg Thr His Pro Asn Ala Leu Tyr Met Ile 
                85                  90                  95      

Leu Tyr Leu Met Ala Thr Leu Leu Ser Ala Leu Gly Ala Gly Phe Phe 
            100                 105                 110         

Thr Thr Met Ala Val Cys Cys Pro Leu Ala Ile Thr Leu Cys Gln Lys 
        115                 120                 125             

Ala Asp Lys His Pro Leu Ile Gly Ala Gln Ala Val Asn Trp Gly Ala 
    130                 135                 140                 

Ser Gly Gly Ala Asn Leu Ile Thr Ser Ser Ser Gly Ile Val Phe Gln 
145                 150                 155                 160 

Gly Leu Phe Lys Gln Met Gly Trp Glu Glu Gln Ala Phe Ser Leu Gly 
                165                 170                 175     

Asn His Ile Phe Ile Val Ser Ile Ile Tyr Pro Leu Ile Val Leu Leu 
            180                 185                 190         

Leu Leu Ser Cys Tyr Ser His Tyr Ser Lys Gly Arg Thr Asn Ser Ser 
        195                 200                 205             

Leu Thr Ile Asp Gln Pro Pro Leu Leu Ser Lys Val Gln Arg Gln Thr 
    210                 215                 220                 

Thr Leu Leu Met Ile Ser Ser Met Val Leu Val Trp Leu Phe Pro Leu 
225                 230                 235                 240 

Leu His Leu Ile Phe Pro Asn Ile Ala Trp Ile Ala Thr Tyr Gln Lys 
                245                 250                 255     

Thr Phe Asp Ile Gly Phe Val Ser Ile Leu Met Val Cys Leu Ala Leu 
            260                 265                 270         

Arg Leu Lys Leu Gly Lys Gln Glu Ala Ile Leu Ala Lys Val Pro Trp 
        275                 280                 285             

Ala Thr Ile Ile Met Leu Cys Gly Met Ser Leu Leu Met Ser Leu Ala 
    290                 295                 300                 

Val Lys Ser Gly Leu Val Thr Leu Ile Gly His Leu Met Thr Thr Thr 
305                 310                 315                 320 

Ile Pro His Phe Trp Leu Pro Leu Phe Phe Cys Val Ile Ala Gly Val 
                325                 330                 335     

Met Ser Leu Phe Ser Ser Thr Leu Ser Val Val Ala Pro Ala Leu Phe 
            340                 345                 350         

Pro Ile Ile Ala Ile Ile Ser Ala Gln Asn Pro Gln Ile Asp Ile His 
        355                 360                 365             

Leu Leu Thr Thr Ala Thr Val Ile Gly Ala Leu Ser Thr Asn Ile Ser 
    370                 375                 380                 

Pro Phe Ser Ser Ala Gly Ser Leu Ile Gln Leu Ser Leu Pro Asn Ile 
385                 390                 395                 400 

Glu Glu Arg Gly Leu Ala Phe Lys Lys Gln Ile Ile Leu Gly Val Pro 
                405                 410                 415     

Ile Ser Leu Ser Leu Gly Leu Leu Thr Thr Trp Ile Leu Ile Leu Leu 
            420                 425                 430         

Ala Ser Leu Ser 
        435     

<210>   4201
<211>   126
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4201
atgattagtt caactttaaa aattcatccc aatagtcttt atcgatggat tcaagaatat   60
gaaaaatatg aagaaagtgc gttcccagga catgggagcg cacttcgtca tactcaattt   120
gagata                                                              126

<210>   4202
<211>   42
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, IS3 family, truncation FRAMESHIFT

<400>   4202
Met Ile Ser Ser Thr Leu Lys Ile His Pro Asn Ser Leu Tyr Arg Trp 
1               5                   10                  15      

Ile Gln Glu Tyr Glu Lys Tyr Glu Glu Ser Ala Phe Pro Gly His Gly 
            20                  25                  30          

Ser Ala Leu Arg His Thr Gln Phe Glu Ile 
        35                  40          

<210>   4203
<211>   192
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4203
atgaagggga aagagtatga aaacagaact gtttcttttg ctattagttc aaaaggagaa   60
aaaatgaaag tagaaaatat ttcgtatagg gtggatcatc gtaaattgtt tgataatatt   120
tcttttgata cttcgagttc agacgtgaca ttaattactg gtaaaaatgg tacaggaaag   180
tcaactttac ta                                                       192

<210>   4204
<211>   64
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903873 (2.E-30)

<400>   4204
Met Lys Gly Lys Glu Tyr Glu Asn Arg Thr Val Ser Phe Ala Ile Ser 
1               5                   10                  15      

Ser Lys Gly Glu Lys Met Lys Val Glu Asn Ile Ser Tyr Arg Val Asp 
            20                  25                  30          

His Arg Lys Leu Phe Asp Asn Ile Ser Phe Asp Thr Ser Ser Ser Asp 
        35                  40                  45              

Val Thr Leu Ile Thr Gly Lys Asn Gly Thr Gly Lys Ser Thr Leu Leu 
    50                  55                  60                  


<210>   4205
<211>   117
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4205
ttgagtactc gattagtcgt catcgctatg atttatttga atttaattct tttgcattac   60
gacattcctc ctaggagaaa atgtgaaaat gaagccaatc ttttacagac tctagtt      117

<210>   4206
<211>   39
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4206
Met Ser Thr Arg Leu Val Val Ile Ala Met Ile Tyr Leu Asn Leu Ile 
1               5                   10                  15      

Leu Leu His Tyr Asp Ile Pro Pro Arg Arg Lys Cys Glu Asn Glu Ala 
            20                  25                  30          

Asn Leu Leu Gln Thr Leu Val 
        35                  

<210>   4207
<211>   726
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4207
atgagtacaa aatatttatt tatttacaat gagattcgtg aaaagattct ttgtaataaa   60
tataccatga acgaacaatt gcctgatgaa atgacattag ctaaacagtt tgcctgtagt   120
cgaatgacga tcaaaaaagc tttagacttg ttagtttctg agggcttaat ttttagaaaa   180
cgtgggcagg gaacctttgt tctctctcgt ggcagctcaa aaagaaaatt aatcgttcca   240
gaaagagata tccggggact gacaaaaata tctgaagatg ctcattctac aattgactcg   300
aggattattc acttcaaatt agaatttgca aatgaatttt tagcagaaaa actacaggtc   360
gctttgcaga gtccagttta taatatttac cgcctgcgta ttattgacgg taaaccttat   420
gttctggaac aaacttatat gagtaccgat gttattccag gtattactga agatatttta   480
caaaaatcga tttacaatta cattgaagga aagttaggat tgcatattgc cagtgctaca   540
aaaatcttac gagcttcttc tagttcagaa aatgagcaac attacttgca gctccttcca   600
acggaaccgg tatttgaagt agaacaagtg gcttatttgg ataacggaac tccgtttgag   660
tactcgatta gtcgtcatcg ctatgattta tttgaattta attcttttgc attacgacat   720
tcctcc                                                              726

<210>   4208
<211>   242
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, GntR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903874 (e-136)

<400>   4208
Met Ser Thr Lys Tyr Leu Phe Ile Tyr Asn Glu Ile Arg Glu Lys Ile 
1               5                   10                  15      

Leu Cys Asn Lys Tyr Thr Met Asn Glu Gln Leu Pro Asp Glu Met Thr 
            20                  25                  30          

Leu Ala Lys Gln Phe Ala Cys Ser Arg Met Thr Ile Lys Lys Ala Leu 
        35                  40                  45              

Asp Leu Leu Val Ser Glu Gly Leu Ile Phe Arg Lys Arg Gly Gln Gly 
    50                  55                  60                  

Thr Phe Val Leu Ser Arg Gly Ser Ser Lys Arg Lys Leu Ile Val Pro 
65                  70                  75                  80  

Glu Arg Asp Ile Arg Gly Leu Thr Lys Ile Ser Glu Asp Ala His Ser 
                85                  90                  95      

Thr Ile Asp Ser Arg Ile Ile His Phe Lys Leu Glu Phe Ala Asn Glu 
            100                 105                 110         

Phe Leu Ala Glu Lys Leu Gln Val Ala Leu Gln Ser Pro Val Tyr Asn 
        115                 120                 125             

Ile Tyr Arg Leu Arg Ile Ile Asp Gly Lys Pro Tyr Val Leu Glu Gln 
    130                 135                 140                 

Thr Tyr Met Ser Thr Asp Val Ile Pro Gly Ile Thr Glu Asp Ile Leu 
145                 150                 155                 160 

Gln Lys Ser Ile Tyr Asn Tyr Ile Glu Gly Lys Leu Gly Leu His Ile 
                165                 170                 175     

Ala Ser Ala Thr Lys Ile Leu Arg Ala Ser Ser Ser Ser Glu Asn Glu 
            180                 185                 190         

Gln His Tyr Leu Gln Leu Leu Pro Thr Glu Pro Val Phe Glu Val Glu 
        195                 200                 205             

Gln Val Ala Tyr Leu Asp Asn Gly Thr Pro Phe Glu Tyr Ser Ile Ser 
    210                 215                 220                 

Arg His Arg Tyr Asp Leu Phe Glu Phe Asn Ser Phe Ala Leu Arg His 
225                 230                 235                 240 

Ser Ser 
        

<210>   4209
<211>   132
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4209
atgcattatt ccaagaccag caatcaaatg cggtccaagc gtggtatcca aaacagtgac   60
ttccctcttc aatggcttta tgtagccatc ttaaatgttc ttcataaaat tcaatacgat   120
acacgtcatc ga                                                       132

<210>   4210
<211>   44
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4210
Met His Tyr Ser Lys Thr Ser Asn Gln Met Arg Ser Lys Arg Gly Ile 
1               5                   10                  15      

Gln Asn Ser Asp Phe Pro Leu Gln Trp Leu Tyr Val Ala Ile Leu Asn 
            20                  25                  30          

Val Leu His Lys Ile Gln Tyr Asp Thr Arg His Arg 
        35                  40                  

<210>   4211
<211>   1449
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4211
atgctatact ttatgtatag aataatagaa aggaggttga gcatgaaaaa aaagttagta   60
tttcctaatc tgttttggtg gggagctgct tctagcggac ctcagacaga aggtcaatat   120
ggaaaagtac atgaaaatgt gatggactac tggttcaaaa cgcatccaga agattttttc   180
gataatgtcg gacctcttgt agccagtaac ttttttcata cttacaccga agatttccac   240
ttgatgaagg aaattggagt taattctttc cgcacttcca tccaatggag tcgactcatc   300
aagaatttag agacaggtga gcctgatcca aaaggtattg ctttctacaa tgccatcatt   360
gaagaagcta aaaagaacca gatggatctt gtgatgaatt tacatcattt tgatttacca   420
gtggaacttc ttcaaaaata cggtggttgg gaaagcaaac atgtagtgga gttattcgtg   480
aagtttgcca agactgcttt cacatgcttt ggagataagg ttcattactg gacaactttc   540
aatgagccaa tggtcattcc agaagcagga tacttatatg ctttccatta tccaaatcta   600
aaaggaaagg gaaaagaggc cgtacaagtc atctataatc taaaccttgc tagtgcaaaa   660
gtgattcaac tatatcgctc attagaactt gatggaaaga ttgggattat tttaaacttg   720
acacctgctt atccaagaag taattctcca gaagacttag aagcaagtcg atttacagat   780
gacttcttta acaaagtctt cttgaatcca gctgttaaag gaactttccc agaaagattg   840
gtaaaacagc tagagagaga tggcgtgtta tggagtcata ccgaaaaaga gcttcaactg   900
atgaaatcaa atacggttga ttttcttgga gtaaactact accatccaaa acgtgttcaa   960
gcacaagcaa atcctgagga atatcagacg ccctggatgc cagaccaata cttcaaagag   1020
tatgaatggc tggagcgtcg catgaatcca tatcgtggtt gggaaatttt tccgaaagcc   1080
atttatgata ttgctatgat tgtgaaggaa gaatatggta atatcccatg gtttatcagt   1140
gaaaacggaa tgggtgttga aaacgaagca cggtttatcg atgaaaatgg agttatcgat   1200
gacgtgtatc gtattgaatt ttatgaagaa catttaagat ggctacataa agccattgaa   1260
gagggaagtc actgttttgg ataccacgct tggaccgcat ttgattgctg gtcttggaat   1320
aatgcatata agaatcgtta cggatttatc tccgttgatt tagaaacgca aaagagaacc   1380
atcaagagct caggaagatg gtatcgcaaa gtaagtgaca ataacggttt tgaagtagaa   1440
attgaggag                                                           1449

<210>   4212
<211>   483
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl hydrolase, family 1
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903875 (0.E+01)

<400>   4212
Met Leu Tyr Phe Met Tyr Arg Ile Ile Glu Arg Arg Leu Ser Met Lys 
1               5                   10                  15      

Lys Lys Leu Val Phe Pro Asn Leu Phe Trp Trp Gly Ala Ala Ser Ser 
            20                  25                  30          

Gly Pro Gln Thr Glu Gly Gln Tyr Gly Lys Val His Glu Asn Val Met 
        35                  40                  45              

Asp Tyr Trp Phe Lys Thr His Pro Glu Asp Phe Phe Asp Asn Val Gly 
    50                  55                  60                  

Pro Leu Val Ala Ser Asn Phe Phe His Thr Tyr Thr Glu Asp Phe His 
65                  70                  75                  80  

Leu Met Lys Glu Ile Gly Val Asn Ser Phe Arg Thr Ser Ile Gln Trp 
                85                  90                  95      

Ser Arg Leu Ile Lys Asn Leu Glu Thr Gly Glu Pro Asp Pro Lys Gly 
            100                 105                 110         

Ile Ala Phe Tyr Asn Ala Ile Ile Glu Glu Ala Lys Lys Asn Gln Met 
        115                 120                 125             

Asp Leu Val Met Asn Leu His His Phe Asp Leu Pro Val Glu Leu Leu 
    130                 135                 140                 

Gln Lys Tyr Gly Gly Trp Glu Ser Lys His Val Val Glu Leu Phe Val 
145                 150                 155                 160 

Lys Phe Ala Lys Thr Ala Phe Thr Cys Phe Gly Asp Lys Val His Tyr 
                165                 170                 175     

Trp Thr Thr Phe Asn Glu Pro Met Val Ile Pro Glu Ala Gly Tyr Leu 
            180                 185                 190         

Tyr Ala Phe His Tyr Pro Asn Leu Lys Gly Lys Gly Lys Glu Ala Val 
        195                 200                 205             

Gln Val Ile Tyr Asn Leu Asn Leu Ala Ser Ala Lys Val Ile Gln Leu 
    210                 215                 220                 

Tyr Arg Ser Leu Glu Leu Asp Gly Lys Ile Gly Ile Ile Leu Asn Leu 
225                 230                 235                 240 

Thr Pro Ala Tyr Pro Arg Ser Asn Ser Pro Glu Asp Leu Glu Ala Ser 
                245                 250                 255     

Arg Phe Thr Asp Asp Phe Phe Asn Lys Val Phe Leu Asn Pro Ala Val 
            260                 265                 270         

Lys Gly Thr Phe Pro Glu Arg Leu Val Lys Gln Leu Glu Arg Asp Gly 
        275                 280                 285             

Val Leu Trp Ser His Thr Glu Lys Glu Leu Gln Leu Met Lys Ser Asn 
    290                 295                 300                 

Thr Val Asp Phe Leu Gly Val Asn Tyr Tyr His Pro Lys Arg Val Gln 
305                 310                 315                 320 

Ala Gln Ala Asn Pro Glu Glu Tyr Gln Thr Pro Trp Met Pro Asp Gln 
                325                 330                 335     

Tyr Phe Lys Glu Tyr Glu Trp Leu Glu Arg Arg Met Asn Pro Tyr Arg 
            340                 345                 350         

Gly Trp Glu Ile Phe Pro Lys Ala Ile Tyr Asp Ile Ala Met Ile Val 
        355                 360                 365             

Lys Glu Glu Tyr Gly Asn Ile Pro Trp Phe Ile Ser Glu Asn Gly Met 
    370                 375                 380                 

Gly Val Glu Asn Glu Ala Arg Phe Ile Asp Glu Asn Gly Val Ile Asp 
385                 390                 395                 400 

Asp Val Tyr Arg Ile Glu Phe Tyr Glu Glu His Leu Arg Trp Leu His 
                405                 410                 415     

Lys Ala Ile Glu Glu Gly Ser His Cys Phe Gly Tyr His Ala Trp Thr 
            420                 425                 430         

Ala Phe Asp Cys Trp Ser Trp Asn Asn Ala Tyr Lys Asn Arg Tyr Gly 
        435                 440                 445             

Phe Ile Ser Val Asp Leu Glu Thr Gln Lys Arg Thr Ile Lys Ser Ser 
    450                 455                 460                 

Gly Arg Trp Tyr Arg Lys Val Ser Asp Asn Asn Gly Phe Glu Val Glu 
465                 470                 475                 480 

Ile Glu Glu 
            

<210>   4213
<211>   1293
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4213
atgaaaaact caaaatttat agaccaattt gccacctttg ctggtaaact agggaaccaa   60
attcatttaa aaaccctaag agatgcattc gtaacagtaa tgccattata tattttggca   120
ggtttaatcg ttcttttgaa caacacggta tttaagtgga ttttccaagg ggatacatta   180
acaagattcc aatattgggg aataacaatt gcaaacggta ctttaagtat ttcaggtatg   240
attattgctg taatggttgg ttatttctta gctaaaaaca gagatttcga aaacccgtta   300
gcagcatcaa tgctatcatt agtttcttta attgtgatga tgccaaatac agtttctgta   360
gttcctgacg gagcaaaaga tgcggtaaac atttcaggtg ttctttcatt caacaacaca   420
ggtacaggcg caatgttcgc cggggttatc gtagcgatta ttgcaacaga attattcatt   480
gaattatcaa acgttaaagc tttacaaatg aaccttggtg aaaatattcc accagctgtt   540
agtagatcat ttagcgtatt acttccagtc atgaccgtca tctccttatt tggggttgtt   600
tcagcattat tattcaatat aactggaatg aacttaatct caatcattac aatctttatt   660
caagaaccaa ttcgtcatat tggtacaagc ttaatcgggg tcattattat ttactcttta   720
ggaaatatgt tatggctatt tggtattcac caagcagtta tttacagtgc catcctagaa   780
ccattactat taattaacat tactgaaaac atcactgcag caaataatgg acaagccatt   840
ccacacatca tcaacctatc acaaatacaa acattcgctt taatgggtgg tagtggatct   900
acattatgtt tattaatagc aacattctta gtgagtcgca atgctgtctc taaaaacgtg   960
gctaaattat cttttggacc tggtatcttc aatatcaatg aaccagtatt attcggttac   1020
ccaatcgttt ataacatttc attagctatt ccatttatca cagttccagt ccttggtatt   1080
ttaatcagct acttagcaac agttacagaa ttcatgagtc ctgcatttat acaagttcct   1140
tggactacac cagtattctt aaatgcatgg ttagcaacag caggggacgt gagagcagtt   1200
ctagttcaat tcatcatctt tgcacttgga gttcttctat acattccatt tatcaaagtt   1260
aatgacaaag ttgttgaaca agaaatggaa ggt                                1293

<210>   4214
<211>   431
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIC component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903876 (0.E+01)

<400>   4214
Met Lys Asn Ser Lys Phe Ile Asp Gln Phe Ala Thr Phe Ala Gly Lys 
1               5                   10                  15      

Leu Gly Asn Gln Ile His Leu Lys Thr Leu Arg Asp Ala Phe Val Thr 
            20                  25                  30          

Val Met Pro Leu Tyr Ile Leu Ala Gly Leu Ile Val Leu Leu Asn Asn 
        35                  40                  45              

Thr Val Phe Lys Trp Ile Phe Gln Gly Asp Thr Leu Thr Arg Phe Gln 
    50                  55                  60                  

Tyr Trp Gly Ile Thr Ile Ala Asn Gly Thr Leu Ser Ile Ser Gly Met 
65                  70                  75                  80  

Ile Ile Ala Val Met Val Gly Tyr Phe Leu Ala Lys Asn Arg Asp Phe 
                85                  90                  95      

Glu Asn Pro Leu Ala Ala Ser Met Leu Ser Leu Val Ser Leu Ile Val 
            100                 105                 110         

Met Met Pro Asn Thr Val Ser Val Val Pro Asp Gly Ala Lys Asp Ala 
        115                 120                 125             

Val Asn Ile Ser Gly Val Leu Ser Phe Asn Asn Thr Gly Thr Gly Ala 
    130                 135                 140                 

Met Phe Ala Gly Val Ile Val Ala Ile Ile Ala Thr Glu Leu Phe Ile 
145                 150                 155                 160 

Glu Leu Ser Asn Val Lys Ala Leu Gln Met Asn Leu Gly Glu Asn Ile 
                165                 170                 175     

Pro Pro Ala Val Ser Arg Ser Phe Ser Val Leu Leu Pro Val Met Thr 
            180                 185                 190         

Val Ile Ser Leu Phe Gly Val Val Ser Ala Leu Leu Phe Asn Ile Thr 
        195                 200                 205             

Gly Met Asn Leu Ile Ser Ile Ile Thr Ile Phe Ile Gln Glu Pro Ile 
    210                 215                 220                 

Arg His Ile Gly Thr Ser Leu Ile Gly Val Ile Ile Ile Tyr Ser Leu 
225                 230                 235                 240 

Gly Asn Met Leu Trp Leu Phe Gly Ile His Gln Ala Val Ile Tyr Ser 
                245                 250                 255     

Ala Ile Leu Glu Pro Leu Leu Leu Ile Asn Ile Thr Glu Asn Ile Thr 
            260                 265                 270         

Ala Ala Asn Asn Gly Gln Ala Ile Pro His Ile Ile Asn Leu Ser Gln 
        275                 280                 285             

Ile Gln Thr Phe Ala Leu Met Gly Gly Ser Gly Ser Thr Leu Cys Leu 
    290                 295                 300                 

Leu Ile Ala Thr Phe Leu Val Ser Arg Asn Ala Val Ser Lys Asn Val 
305                 310                 315                 320 

Ala Lys Leu Ser Phe Gly Pro Gly Ile Phe Asn Ile Asn Glu Pro Val 
                325                 330                 335     

Leu Phe Gly Tyr Pro Ile Val Tyr Asn Ile Ser Leu Ala Ile Pro Phe 
            340                 345                 350         

Ile Thr Val Pro Val Leu Gly Ile Leu Ile Ser Tyr Leu Ala Thr Val 
        355                 360                 365             

Thr Glu Phe Met Ser Pro Ala Phe Ile Gln Val Pro Trp Thr Thr Pro 
    370                 375                 380                 

Val Phe Leu Asn Ala Trp Leu Ala Thr Ala Gly Asp Val Arg Ala Val 
385                 390                 395                 400 

Leu Val Gln Phe Ile Ile Phe Ala Leu Gly Val Leu Leu Tyr Ile Pro 
                405                 410                 415     

Phe Ile Lys Val Asn Asp Lys Val Val Glu Gln Glu Met Glu Gly 
            420                 425                 430     

<210>   4215
<211>   306
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4215
atgaaacaaa ttttattagt atgtaatgcg ggaatgtcga caagtatgct tgttaaaaaa   60
atgcaacaaa gtgcgactga acgtgggatt gaaatctcta tccaagcaaa atcaatgaca   120
gaagctaaaa agaatatcca tgaagcagat gtcattctaa ttgggccaca aattcgttat   180
gagttacttg ctgtgaaaga aattgcagga aatatccctg tagataccat tgatatgcgg   240
gattacggaa tgatgaatgg agcaaaagtt ctggaacaag cacttgcatg gataggagaa   300
ataaga                                                              306

<210>   4216
<211>   102
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIB component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903877 (2.E-52)

<400>   4216
Met Lys Gln Ile Leu Leu Val Cys Asn Ala Gly Met Ser Thr Ser Met 
1               5                   10                  15      

Leu Val Lys Lys Met Gln Gln Ser Ala Thr Glu Arg Gly Ile Glu Ile 
            20                  25                  30          

Ser Ile Gln Ala Lys Ser Met Thr Glu Ala Lys Lys Asn Ile His Glu 
        35                  40                  45              

Ala Asp Val Ile Leu Ile Gly Pro Gln Ile Arg Tyr Glu Leu Leu Ala 
    50                  55                  60                  

Val Lys Glu Ile Ala Gly Asn Ile Pro Val Asp Thr Ile Asp Met Arg 
65                  70                  75                  80  

Asp Tyr Gly Met Met Asn Gly Ala Lys Val Leu Glu Gln Ala Leu Ala 
                85                  90                  95      

Trp Ile Gly Glu Ile Arg 
            100         

<210>   4217
<211>   324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4217
atggatagga gaaataagat gacagaagaa atggaatata tctgttttca gctcattgcc   60
aatagtggag cagccaaatc atcctttatt gaagccatcc aactagctaa ggcaggaaat   120
ttaaaagaag cgaaaattaa agttgaagaa gcggaagact ccttagtaga agcgcacaag   180
attcactcta atctcataca aaaagaagct actggagaaa aaataggatt ctccttgcta   240
tttatgcatg cagaagacca aatggcttca acagagatta ttcagttgct atctaaagaa   300
ttcatcgatc tctatcaaaa taaa                                          324

<210>   4218
<211>   108
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIA component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903878 (3.E-56)

<400>   4218
Met Asp Arg Arg Asn Lys Met Thr Glu Glu Met Glu Tyr Ile Cys Phe 
1               5                   10                  15      

Gln Leu Ile Ala Asn Ser Gly Ala Ala Lys Ser Ser Phe Ile Glu Ala 
            20                  25                  30          

Ile Gln Leu Ala Lys Ala Gly Asn Leu Lys Glu Ala Lys Ile Lys Val 
        35                  40                  45              

Glu Glu Ala Glu Asp Ser Leu Val Glu Ala His Lys Ile His Ser Asn 
    50                  55                  60                  

Leu Ile Gln Lys Glu Ala Thr Gly Glu Lys Ile Gly Phe Ser Leu Leu 
65                  70                  75                  80  

Phe Met His Ala Glu Asp Gln Met Ala Ser Thr Glu Ile Ile Gln Leu 
                85                  90                  95      

Leu Ser Lys Glu Phe Ile Asp Leu Tyr Gln Asn Lys 
            100                 105             

<210>   4219
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4219
atgagggggc tagtcttatc tgcaatctca aatcagtgtt ttgagctgaa tggcactcgt   60
tttctagttt gctctttgat tttaattggg cct                                93

<210>   4220
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4220
Met Arg Gly Leu Val Leu Ser Ala Ile Ser Asn Gln Cys Phe Glu Leu 
1               5                   10                  15      

Asn Gly Thr Arg Phe Leu Val Cys Ser Leu Ile Leu Ile Gly Pro 
            20                  25                  30      

<210>   4221
<211>   2649
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4221
atggctgata aaaaaactgt gacaccagag gaaaagaaac tcgttgctga aaaacacgta   60
gatgagttgg ttcaaaaagc tctagttgcc cttgaagaaa tgcgtaaatt ggatcaagaa   120
caagttgact acatcgttgc caaagcatca gtagcagctt tggatgccca cggagaattg   180
gctttacatg cctttgaaga aacaggacgt ggtgtatttg aagacaaagc aactaagaac   240
ttgtttgcct gtgaacacgt agtaaacaac atgcgccaca ctaagacagt tggcgttatc   300
gaagaagacg atgtaacagg attgactctt attgctgaac cagttggtgt tgtttgtggt   360
attactccaa caacaaaccc aacatcaaca gcaatcttca aatcattgat ttcattgaag   420
acacgtaacc caatcgtctt tgccttccat ccatcagcac aagaatcatc tgctcatgca   480
gctcgtatcg tccgcgatgc agctatcgca gctggtgctc ctgaaaactg tgtgcaatgg   540
attactcaac catctatgga agcaacaagt gcccttatga accacgaagg tgttgcgaca   600
atccttgcaa caggtggtaa tgccatggtt aaggcggctt attcatgtgg taaaccagct   660
cttggggtag gtgccggaaa cgttccagct tatgttgaaa aatcagcaaa cattcgtcaa   720
gcagcacacg atatcgtcat gtctaaatca tttgataacg gtatggtctg tgcatctgaa   780
caagcagtta tcattgataa agaaatttac gatgaatttg tagcagagtt caaatcttac   840
cacacttact ttgtaaacaa aaaagaaaaa gctcttcttg aagagttctg cttcggcgtc   900
aaagcaaaca gcaaaaactg tgctggtgca aaattgaacg ctgacatcgt tggtaaacca   960
gcaacttgga ttgcagaaca agcaggattt acagttccag aaggaacaaa cattcttgct   1020
gcagaatgta aagaagttgg cgaaaatgag ccattgactc gtgaaaaatt gtcaccagtt   1080
attgcagttt tgaaatctga aagccgtgaa gatggtatta ctaaggctcg tcaaatggtt   1140
gaatttaacg gtcttggaca ctcagcagct atccacacag ctgacgaaga attgactaaa   1200
gaatttggta aagctgttaa agctattcgt gttatctgta actcaccttc tacttttggt   1260
ggtatcgggg acgtttacaa tgccttcttg ccatcattga cacttggatg tggttcttac   1320
ggacgcaact cagttgggga taacgttagt gccattaacc tcttgaatat caaaaaagtc   1380
ggaagacgga gaaataacat gcaatggatg aaacttcctt caaaaacata ctttgaacgt   1440
gattcaattc aataccttca aaaatgtcgt gacgttgaac gtgtcatgat cgttactgac   1500
catgccatgg tagagcttgg tttccttgat cgtatcatcg aacaactgga ccttcgtcgc   1560
aataaggttg tttaccaaat ctttgcggat gtagaaccgg atccagatat cacaactgta   1620
aaccgtggta ctgagattat gcgtgccttc aaaccagata ccatcatcgc actcggtggt   1680
gggtctccaa tggatgctgc caaagtaatg tggctcttct acgagcaacc agaagtggac   1740
ttccgtgacc ttgtccaaaa attcatggat atccgtaaac gtgccttcaa gttcccattg   1800
cttggtaaga agactaaatt catcgcgatt ccaactacat ctggtacagg atctgaagta   1860
acaccatttg ccgttatctc tgataaagca aacaaccgta aatacccaat cgctgactac   1920
tcattgacac caactgtggc aatcgtagat cctgctttgg tattgacagt tccaggattt   1980
gttgctgctg atactggtat ggacgtattg actcacgcga cagaagcata cgtatcacaa   2040
atggctagtg actacactga tggtttagca cttcaagcca ttaaattggt ctttgaaaat   2100
ctcgaaagct cagttaagaa tgcagacttc cactcacgtg agaaaatgca taacgcttca   2160
acaatcgctg gtatggcctt tgccaatgcc ttcctaggta tttctcactc aatggcccat   2220
aagattggtg cgcaattcca cacaatccac ggtcgtacaa atgctatctt gcttccatac   2280
gttatccgtt acaacggtac acgtccagct aagacagcaa catggcctaa gtacaactac   2340
taccgtgcag atgaaaaata ccaagatatc gcacgcatgc ttggacttcc agcttctact   2400
ccagaagaag gggttgaatc ttacgcaaaa gctgtctacg aactcggtga acgtattggg   2460
atccaaatga attttagaga ccaaggaatt gacgaaaaag aatggaaaga acattctcgt   2520
aaattagcct tcctggctta tgaagaccaa tgttcaccag ctaacccacg tcttccaatg   2580
gtagaccata tgcaagaaat catcgaagat gcatactatg gctacaaaga aagaccagga   2640
cgccgtaaa                                                           2649

<210>   4222
<211>   883
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alcohol dehydrogenase, iron-containing
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903879 (0.E+01)

<400>   4222
Met Ala Asp Lys Lys Thr Val Thr Pro Glu Glu Lys Lys Leu Val Ala 
1               5                   10                  15      

Glu Lys His Val Asp Glu Leu Val Gln Lys Ala Leu Val Ala Leu Glu 
            20                  25                  30          

Glu Met Arg Lys Leu Asp Gln Glu Gln Val Asp Tyr Ile Val Ala Lys 
        35                  40                  45              

Ala Ser Val Ala Ala Leu Asp Ala His Gly Glu Leu Ala Leu His Ala 
    50                  55                  60                  

Phe Glu Glu Thr Gly Arg Gly Val Phe Glu Asp Lys Ala Thr Lys Asn 
65                  70                  75                  80  

Leu Phe Ala Cys Glu His Val Val Asn Asn Met Arg His Thr Lys Thr 
                85                  90                  95      

Val Gly Val Ile Glu Glu Asp Asp Val Thr Gly Leu Thr Leu Ile Ala 
            100                 105                 110         

Glu Pro Val Gly Val Val Cys Gly Ile Thr Pro Thr Thr Asn Pro Thr 
        115                 120                 125             

Ser Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu Lys Thr Arg Asn Pro 
    130                 135                 140                 

Ile Val Phe Ala Phe His Pro Ser Ala Gln Glu Ser Ser Ala His Ala 
145                 150                 155                 160 

Ala Arg Ile Val Arg Asp Ala Ala Ile Ala Ala Gly Ala Pro Glu Asn 
                165                 170                 175     

Cys Val Gln Trp Ile Thr Gln Pro Ser Met Glu Ala Thr Ser Ala Leu 
            180                 185                 190         

Met Asn His Glu Gly Val Ala Thr Ile Leu Ala Thr Gly Gly Asn Ala 
        195                 200                 205             

Met Val Lys Ala Ala Tyr Ser Cys Gly Lys Pro Ala Leu Gly Val Gly 
    210                 215                 220                 

Ala Gly Asn Val Pro Ala Tyr Val Glu Lys Ser Ala Asn Ile Arg Gln 
225                 230                 235                 240 

Ala Ala His Asp Ile Val Met Ser Lys Ser Phe Asp Asn Gly Met Val 
                245                 250                 255     

Cys Ala Ser Glu Gln Ala Val Ile Ile Asp Lys Glu Ile Tyr Asp Glu 
            260                 265                 270         

Phe Val Ala Glu Phe Lys Ser Tyr His Thr Tyr Phe Val Asn Lys Lys 
        275                 280                 285             

Glu Lys Ala Leu Leu Glu Glu Phe Cys Phe Gly Val Lys Ala Asn Ser 
    290                 295                 300                 

Lys Asn Cys Ala Gly Ala Lys Leu Asn Ala Asp Ile Val Gly Lys Pro 
305                 310                 315                 320 

Ala Thr Trp Ile Ala Glu Gln Ala Gly Phe Thr Val Pro Glu Gly Thr 
                325                 330                 335     

Asn Ile Leu Ala Ala Glu Cys Lys Glu Val Gly Glu Asn Glu Pro Leu 
            340                 345                 350         

Thr Arg Glu Lys Leu Ser Pro Val Ile Ala Val Leu Lys Ser Glu Ser 
        355                 360                 365             

Arg Glu Asp Gly Ile Thr Lys Ala Arg Gln Met Val Glu Phe Asn Gly 
    370                 375                 380                 

Leu Gly His Ser Ala Ala Ile His Thr Ala Asp Glu Glu Leu Thr Lys 
385                 390                 395                 400 

Glu Phe Gly Lys Ala Val Lys Ala Ile Arg Val Ile Cys Asn Ser Pro 
                405                 410                 415     

Ser Thr Phe Gly Gly Ile Gly Asp Val Tyr Asn Ala Phe Leu Pro Ser 
            420                 425                 430         

Leu Thr Leu Gly Cys Gly Ser Tyr Gly Arg Asn Ser Val Gly Asp Asn 
        435                 440                 445             

Val Ser Ala Ile Asn Leu Leu Asn Ile Lys Lys Val Gly Arg Arg Arg 
    450                 455                 460                 

Asn Asn Met Gln Trp Met Lys Leu Pro Ser Lys Thr Tyr Phe Glu Arg 
465                 470                 475                 480 

Asp Ser Ile Gln Tyr Leu Gln Lys Cys Arg Asp Val Glu Arg Val Met 
                485                 490                 495     

Ile Val Thr Asp His Ala Met Val Glu Leu Gly Phe Leu Asp Arg Ile 
            500                 505                 510         

Ile Glu Gln Leu Asp Leu Arg Arg Asn Lys Val Val Tyr Gln Ile Phe 
        515                 520                 525             

Ala Asp Val Glu Pro Asp Pro Asp Ile Thr Thr Val Asn Arg Gly Thr 
    530                 535                 540                 

Glu Ile Met Arg Ala Phe Lys Pro Asp Thr Ile Ile Ala Leu Gly Gly 
545                 550                 555                 560 

Gly Ser Pro Met Asp Ala Ala Lys Val Met Trp Leu Phe Tyr Glu Gln 
                565                 570                 575     

Pro Glu Val Asp Phe Arg Asp Leu Val Gln Lys Phe Met Asp Ile Arg 
            580                 585                 590         

Lys Arg Ala Phe Lys Phe Pro Leu Leu Gly Lys Lys Thr Lys Phe Ile 
        595                 600                 605             

Ala Ile Pro Thr Thr Ser Gly Thr Gly Ser Glu Val Thr Pro Phe Ala 
    610                 615                 620                 

Val Ile Ser Asp Lys Ala Asn Asn Arg Lys Tyr Pro Ile Ala Asp Tyr 
625                 630                 635                 640 

Ser Leu Thr Pro Thr Val Ala Ile Val Asp Pro Ala Leu Val Leu Thr 
                645                 650                 655     

Val Pro Gly Phe Val Ala Ala Asp Thr Gly Met Asp Val Leu Thr His 
            660                 665                 670         

Ala Thr Glu Ala Tyr Val Ser Gln Met Ala Ser Asp Tyr Thr Asp Gly 
        675                 680                 685             

Leu Ala Leu Gln Ala Ile Lys Leu Val Phe Glu Asn Leu Glu Ser Ser 
    690                 695                 700                 

Val Lys Asn Ala Asp Phe His Ser Arg Glu Lys Met His Asn Ala Ser 
705                 710                 715                 720 

Thr Ile Ala Gly Met Ala Phe Ala Asn Ala Phe Leu Gly Ile Ser His 
                725                 730                 735     

Ser Met Ala His Lys Ile Gly Ala Gln Phe His Thr Ile His Gly Arg 
            740                 745                 750         

Thr Asn Ala Ile Leu Leu Pro Tyr Val Ile Arg Tyr Asn Gly Thr Arg 
        755                 760                 765             

Pro Ala Lys Thr Ala Thr Trp Pro Lys Tyr Asn Tyr Tyr Arg Ala Asp 
    770                 775                 780                 

Glu Lys Tyr Gln Asp Ile Ala Arg Met Leu Gly Leu Pro Ala Ser Thr 
785                 790                 795                 800 

Pro Glu Glu Gly Val Glu Ser Tyr Ala Lys Ala Val Tyr Glu Leu Gly 
                805                 810                 815     

Glu Arg Ile Gly Ile Gln Met Asn Phe Arg Asp Gln Gly Ile Asp Glu 
            820                 825                 830         

Lys Glu Trp Lys Glu His Ser Arg Lys Leu Ala Phe Leu Ala Tyr Glu 
        835                 840                 845             

Asp Gln Cys Ser Pro Ala Asn Pro Arg Leu Pro Met Val Asp His Met 
    850                 855                 860                 

Gln Glu Ile Ile Glu Asp Ala Tyr Tyr Gly Tyr Lys Glu Arg Pro Gly 
865                 870                 875                 880 

Arg Arg Lys 
            

<210>   4223
<211>   408
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4223
gtggaaaatc ttacgaattt ttacgaaaag tatcgtgtct atctgactcg tccacgttta   60
gagcttttgg cagtagttac cattgttttc tgtgctgtac tcgtcttttt tctaaatatt   120
ccaggaaaag gtgtcttaaa actcgataat ggaacgattg tttatgatgg cagtcttgtc   180
cgcggtaaaa tgaatggcca aggtaccatt accttccaaa atggagacca atatacaggt   240
ggcttcaaca atggagcctt caacggaaaa ggtacctttc aatctaaaga aggctggacc   300
tacgaaggtg attttgtaaa tggtcaggct gaaggaaaag ggaaactaac aacagaacaa   360
gaagtcgttt atgaaggaac ttttaaacaa ggcgtttttc aacaaaaa                408

<210>   4224
<211>   136
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903880 (9.E-78)

<400>   4224
Met Glu Asn Leu Thr Asn Phe Tyr Glu Lys Tyr Arg Val Tyr Leu Thr 
1               5                   10                  15      

Arg Pro Arg Leu Glu Leu Leu Ala Val Val Thr Ile Val Phe Cys Ala 
            20                  25                  30          

Val Leu Val Phe Phe Leu Asn Ile Pro Gly Lys Gly Val Leu Lys Leu 
        35                  40                  45              

Asp Asn Gly Thr Ile Val Tyr Asp Gly Ser Leu Val Arg Gly Lys Met 
    50                  55                  60                  

Asn Gly Gln Gly Thr Ile Thr Phe Gln Asn Gly Asp Gln Tyr Thr Gly 
65                  70                  75                  80  

Gly Phe Asn Asn Gly Ala Phe Asn Gly Lys Gly Thr Phe Gln Ser Lys 
                85                  90                  95      

Glu Gly Trp Thr Tyr Glu Gly Asp Phe Val Asn Gly Gln Ala Glu Gly 
            100                 105                 110         

Lys Gly Lys Leu Thr Thr Glu Gln Glu Val Val Tyr Glu Gly Thr Phe 
        115                 120                 125             

Lys Gln Gly Val Phe Gln Gln Lys 
    130                 135     

<210>   4225
<211>   426
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4225
atgaaaaaat tagtctttgt ctgtctggga aatatttgcc gtagccctat ggccgagttt   60
gttatgaaat caatgacaga taactacgaa atccaaagtc gagcaacttc ctcttgggaa   120
catggcaatc cgattcataa ggggactcag ggaatttttc aagagtatga gattccttat   180
gacaagaaca agacatcgct tcagattagt aaggaagatt ttgaagcctt tgattatatt   240
atcggaatgg acgcttcaaa tatttctgac ttacgtcaga tgtgtccagt agactgtcaa   300
gataagattt actcattttc atctgaaagt gttccagacc cttggtatac aggagatttt   360
gaagaaacct atcgacgtgt tcaagagggc tgtcaagctt ggttagaacg tttagaaaag   420
gagagt                                                              426

<210>   4226
<211>   142
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphotyrosine protein phosphatase
<223>   Similar to strain R6 sequence 15903881 (4.E-83)

<400>   4226
Met Lys Lys Leu Val Phe Val Cys Leu Gly Asn Ile Cys Arg Ser Pro 
1               5                   10                  15      

Met Ala Glu Phe Val Met Lys Ser Met Thr Asp Asn Tyr Glu Ile Gln 
            20                  25                  30          

Ser Arg Ala Thr Ser Ser Trp Glu His Gly Asn Pro Ile His Lys Gly 
        35                  40                  45              

Thr Gln Gly Ile Phe Gln Glu Tyr Glu Ile Pro Tyr Asp Lys Asn Lys 
    50                  55                  60                  

Thr Ser Leu Gln Ile Ser Lys Glu Asp Phe Glu Ala Phe Asp Tyr Ile 
65                  70                  75                  80  

Ile Gly Met Asp Ala Ser Asn Ile Ser Asp Leu Arg Gln Met Cys Pro 
                85                  90                  95      

Val Asp Cys Gln Asp Lys Ile Tyr Ser Phe Ser Ser Glu Ser Val Pro 
            100                 105                 110         

Asp Pro Trp Tyr Thr Gly Asp Phe Glu Glu Thr Tyr Arg Arg Val Gln 
        115                 120                 125             

Glu Gly Cys Gln Ala Trp Leu Glu Arg Leu Glu Lys Glu Ser 
    130                 135                 140         

<210>   4227
<211>   297
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4227
atgaatccaa atattacttt tttaatcatg cttgtaggta tgatggcctt gatgttcttt   60
atgcaacgtt ctcaaaagaa acaagctcaa aagcgtatgg aaagcttaaa taaactacaa   120
aaaggctatg aagtgattac aatcggtgga ctttatggaa cagtcgatga agtagatacg   180
gagaagggaa caatagttct tgacgtagat ggagtttact tgacttttga actagctgct   240
atcaagacag tattaccgct gaaagaaaca gcttcactag aaggcgcaat tgaaaaa      297

<210>   4228
<211>   99
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   preprotein translocase, YajC subunit (yajC)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903882 (3.E-51)

<400>   4228
Met Asn Pro Asn Ile Thr Phe Leu Ile Met Leu Val Gly Met Met Ala 
1               5                   10                  15      

Leu Met Phe Phe Met Gln Arg Ser Gln Lys Lys Gln Ala Gln Lys Arg 
            20                  25                  30          

Met Glu Ser Leu Asn Lys Leu Gln Lys Gly Tyr Glu Val Ile Thr Ile 
        35                  40                  45              

Gly Gly Leu Tyr Gly Thr Val Asp Glu Val Asp Thr Glu Lys Gly Thr 
    50                  55                  60                  

Ile Val Leu Asp Val Asp Gly Val Tyr Leu Thr Phe Glu Leu Ala Ala 
65                  70                  75                  80  

Ile Lys Thr Val Leu Pro Leu Lys Glu Thr Ala Ser Leu Glu Gly Ala 
                85                  90                  95      

Ile Glu Lys 
            

<210>   4229
<211>   1974
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4229
atgtcaaatc tatctgttaa tgcaattcgt tttctaggta ttgacgccat taataaagcc   60
aactcaggtc atccaggtgt ggttatggga gcggctccga tggcttacag cctctttaca   120
aaacaacttc atatcaatcc agctcaacca aactggatta accgcgaccg ctttattctt   180
tcagcaggtc atggttcaat gctcctttat gctcttcttc acctttctgg ttttgaagat   240
gtcagcatgg atgagattaa gagtttccgt caatggggtt caaaaacacc aggtcaccca   300
gaatttggtc atacggcagg gattgatgct acgacaggtc ctctagggca agggatttca   360
actgctactg gttttgccca agcagaacgt ttcttggcag ccaaatataa ccgtgaaggt   420
tacaatatct ttgaccacta tacttacgtt atctgtggag acggagactt gatggaaggt   480
gtctcaagcg aggcagcttc atacgcaggc ttgcaaaaac ttgataagtt ggttgttctt   540
tatgattcaa atgatatcaa cttggatggt gagacaaagg attcctttac agaaagtgtt   600
cgtgaccgtt acaatgccta cggttggcat actgccttgg ttgaaaatgg aacagacttg   660
gaagccatcc atgctgctat cgaaacagca aaagcttcag gcaagccatc tttgattgaa   720
gtgaagacgg ttattggata cggttctcca aacaaacaag gaactaatgc tgtacacggc   780
gcccctcttg gagcagatga aactgcatca actcgtcaag ccctcggttg ggactacgaa   840
ccatttgaaa ttccagaaca agtatatgct gatttcaaag aacatgttgc agaccgtggc   900
gcatcagctt atcaagcttg gactaaatta gttgcagatt ataaagaagc tcatccagaa   960
ctggctgcag aagtagaagc catcatcgac ggacgtgatc cagtcgaagt gactccagca   1020
gacttcccag ctttagaaaa tggtttttct caagcaactc gtaattcaag tcaagatgcc   1080
ttgaatgttg tggcagctaa attaccaacc tttctaggtg gatcagctga ccttgctcac   1140
tcaaacatga cttatatcaa gacggatgga cttcaagacg atgccaatcg cttgaatcgt   1200
aacattcagt ttggtgttcg tgaatttgca atgggaacaa tcttgaacgg gatggccctt   1260
catggtggac ttcgtgtata cggtggaact ttcttcgtct tctctgacta tgtgaaggca   1320

gctgtccgct tgtcagcctt acaaggactt cctgtgactt atgtctttac ccatgattca   1380
atcgcagttg gggaagatgg tccgactcat gaaccagttg agcatttagc aggtcttcgt   1440
gctatgccaa atctaaatgt tttccgtcca gcagatgcgc gtgaaacgca agcagcttgg   1500
taccttgcag tgacaagtga gaaaacacca actgcccttg tcttgacacg tcaaaatttg   1560
actgttgaag atggaacaga cttcgacaag gttgctaaag gtgcttatgt tgtatatgaa   1620
aatgcagccg actttgatac catcttgatt gcgacaggtt cagaggttaa tcttgctgtc   1680
tcagctgcta aagaattggc tagtcaaggc gaaaaaatcc gcgtagtcag catgccatct   1740
acagatgtct ttgataaaca agatgcagct tacaaggaag aaattcttcc aaatgcagtc   1800
cgccgtcgtg ttgcagtcga aatgggtgca agtcaaaact ggtacaaata tgttggtctc   1860
gatggtgccg ttctaggtat tgataccttc ggagcctctg ccccagcacc aaaagtattg   1920
gcagaatatg gctttactgt agaaaatctt gtaaaagttg ttcgaaactt gaaa         1974

<210>   4230
<211>   658
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transketolase, FRAMESHIFT (recP)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903883 (0.E+01)

<400>   4230
Met Ser Asn Leu Ser Val Asn Ala Ile Arg Phe Leu Gly Ile Asp Ala 
1               5                   10                  15      

Ile Asn Lys Ala Asn Ser Gly His Pro Gly Val Val Met Gly Ala Ala 
            20                  25                  30          

Pro Met Ala Tyr Ser Leu Phe Thr Lys Gln Leu His Ile Asn Pro Ala 
        35                  40                  45              

Gln Pro Asn Trp Ile Asn Arg Asp Arg Phe Ile Leu Ser Ala Gly His 
    50                  55                  60                  

Gly Ser Met Leu Leu Tyr Ala Leu Leu His Leu Ser Gly Phe Glu Asp 
65                  70                  75                  80  

Val Ser Met Asp Glu Ile Lys Ser Phe Arg Gln Trp Gly Ser Lys Thr 
                85                  90                  95      

Pro Gly His Pro Glu Phe Gly His Thr Ala Gly Ile Asp Ala Thr Thr 
            100                 105                 110         

Gly Pro Leu Gly Gln Gly Ile Ser Thr Ala Thr Gly Phe Ala Gln Ala 
        115                 120                 125             

Glu Arg Phe Leu Ala Ala Lys Tyr Asn Arg Glu Gly Tyr Asn Ile Phe 
    130                 135                 140                 

Asp His Tyr Thr Tyr Val Ile Cys Gly Asp Gly Asp Leu Met Glu Gly 
145                 150                 155                 160 

Val Ser Ser Glu Ala Ala Ser Tyr Ala Gly Leu Gln Lys Leu Asp Lys 
                165                 170                 175     

Leu Val Val Leu Tyr Asp Ser Asn Asp Ile Asn Leu Asp Gly Glu Thr 
            180                 185                 190         

Lys Asp Ser Phe Thr Glu Ser Val Arg Asp Arg Tyr Asn Ala Tyr Gly 
        195                 200                 205             

Trp His Thr Ala Leu Val Glu Asn Gly Thr Asp Leu Glu Ala Ile His 
    210                 215                 220                 

Ala Ala Ile Glu Thr Ala Lys Ala Ser Gly Lys Pro Ser Leu Ile Glu 
225                 230                 235                 240 

Val Lys Thr Val Ile Gly Tyr Gly Ser Pro Asn Lys Gln Gly Thr Asn 
                245                 250                 255     

Ala Val His Gly Ala Pro Leu Gly Ala Asp Glu Thr Ala Ser Thr Arg 
            260                 265                 270         

Gln Ala Leu Gly Trp Asp Tyr Glu Pro Phe Glu Ile Pro Glu Gln Val 
        275                 280                 285             

Tyr Ala Asp Phe Lys Glu His Val Ala Asp Arg Gly Ala Ser Ala Tyr 
    290                 295                 300                 

Gln Ala Trp Thr Lys Leu Val Ala Asp Tyr Lys Glu Ala His Pro Glu 
305                 310                 315                 320 

Leu Ala Ala Glu Val Glu Ala Ile Ile Asp Gly Arg Asp Pro Val Glu 
                325                 330                 335     

Val Thr Pro Ala Asp Phe Pro Ala Leu Glu Asn Gly Phe Ser Gln Ala 
            340                 345                 350         

Thr Arg Asn Ser Ser Gln Asp Ala Leu Asn Val Val Ala Ala Lys Leu 
        355                 360                 365             

Pro Thr Phe Leu Gly Gly Ser Ala Asp Leu Ala His Ser Asn Met Thr 
    370                 375                 380                 

Tyr Ile Lys Thr Asp Gly Leu Gln Asp Asp Ala Asn Arg Leu Asn Arg 
385                 390                 395                 400 

Asn Ile Gln Phe Gly Val Arg Glu Phe Ala Met Gly Thr Ile Leu Asn 
                405                 410                 415     

Gly Met Ala Leu His Gly Gly Leu Arg Val Tyr Gly Gly Thr Phe Phe 
            420                 425                 430         

Val Phe Ser Asp Tyr Val Lys Ala Ala Val Arg Leu Ser Ala Leu Gln 
        435                 440                 445             

Gly Leu Pro Val Thr Tyr Val Phe Thr His Asp Ser Ile Ala Val Gly 
    450                 455                 460                 

Glu Asp Gly Pro Thr His Glu Pro Val Glu His Leu Ala Gly Leu Arg 
465                 470                 475                 480 

Ala Met Pro Asn Leu Asn Val Phe Arg Pro Ala Asp Ala Arg Glu Thr 
                485                 490                 495     

Gln Ala Ala Trp Tyr Leu Ala Val Thr Ser Glu Lys Thr Pro Thr Ala 
            500                 505                 510         

Leu Val Leu Thr Arg Gln Asn Leu Thr Val Glu Asp Gly Thr Asp Phe 
        515                 520                 525             

Asp Lys Val Ala Lys Gly Ala Tyr Val Val Tyr Glu Asn Ala Ala Asp 
    530                 535                 540                 

Phe Asp Thr Ile Leu Ile Ala Thr Gly Ser Glu Val Asn Leu Ala Val 
545                 550                 555                 560 

Ser Ala Ala Lys Glu Leu Ala Ser Gln Gly Glu Lys Ile Arg Val Val 
                565                 570                 575     

Ser Met Pro Ser Thr Asp Val Phe Asp Lys Gln Asp Ala Ala Tyr Lys 
            580                 585                 590         

Glu Glu Ile Leu Pro Asn Ala Val Arg Arg Arg Val Ala Val Glu Met 
        595                 600                 605             

Gly Ala Ser Gln Asn Trp Tyr Lys Tyr Val Gly Leu Asp Gly Ala Val 
    610                 615                 620                 

Leu Gly Ile Asp Thr Phe Gly Ala Ser Ala Pro Ala Pro Lys Val Leu 
625                 630                 635                 640 

Ala Glu Tyr Gly Phe Thr Val Glu Asn Leu Val Lys Val Val Arg Asn 
                645                 650                 655     

Leu Lys 
        

<210>   4231
<211>   1089
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4231
atgccaaacg tcaaagaaat tacaagagag tcatggattt tagccacttt cccagagtgg   60
ggaacatggt tgaacgaaga aatcgaagaa gaagtcgtac ctgaaggcaa ctttgccatg   120
tggtggctag gcaactgtgg tacttggatt aagacaccag ctggtgctaa cgttgtcatg   180
gacctttggt caaaccgtgg aaaatcaacc aaaaaagtga aagatatggt tcgtgggcac   240
caaatggcaa atatggcagg tgttcgtaag ctgcaaccaa acttgcgtgt tcagccaatg   300
gttatcgatc catttgctat caacgaacta gactattact tagtttcaca cttccacagt   360
gatcatatcg acccatacac agctgcagca attctcaata atcctaagtt agagcatgtt   420
aagtttatcg gtccttacca ctgtggacga atctgggaag gatggggtgt tccaaaagaa   480
cgtatcatcg ttgttaaacc aggtgacact atcgaattaa aagatatgaa gattcatgca   540
gtagaatcat ttgaccgtac ttgcttggta actctcccag tgaacggtgc tgatgagaca   600
ggcggtgaac ttgctggctt ggctgttaca gatgaagaaa tggctcaaaa ggctgttaac   660
tatatctttg aaacaccagg tggaaccatc tatcatggtg cagattctca cttctcaaac   720
tattttgcaa aacatggtaa agactttaaa attgatgttg ctttgaataa ctatggtgaa   780
aatccggtag gtatccaaga caaaatgaca tctatcgacc ttcttcgtat ggcagaaaat   840
ctgcgtacca aagtcattat cccagttcac tatgatatct ggtctaactt catggcttct   900
actaatgaga ttctagaact ttggaaaatg cgaaaagatc gcttgcaata cgatttccat   960
ccatttatct gggaagttgg cggtaagtac acttatcctc aagatcaaca cttagtagaa   1020
taccatcatc cacgtggttt tgatgattgt tttgaacaag actctaacat tcaatttaaa   1080
gctttgcta                                                           1089

<210>   4232
<211>   363
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903884 (0.E+01)

<400>   4232
Met Pro Asn Val Lys Glu Ile Thr Arg Glu Ser Trp Ile Leu Ala Thr 
1               5                   10                  15      

Phe Pro Glu Trp Gly Thr Trp Leu Asn Glu Glu Ile Glu Glu Glu Val 
            20                  25                  30          

Val Pro Glu Gly Asn Phe Ala Met Trp Trp Leu Gly Asn Cys Gly Thr 
        35                  40                  45              

Trp Ile Lys Thr Pro Ala Gly Ala Asn Val Val Met Asp Leu Trp Ser 
    50                  55                  60                  

Asn Arg Gly Lys Ser Thr Lys Lys Val Lys Asp Met Val Arg Gly His 
65                  70                  75                  80  

Gln Met Ala Asn Met Ala Gly Val Arg Lys Leu Gln Pro Asn Leu Arg 
                85                  90                  95      

Val Gln Pro Met Val Ile Asp Pro Phe Ala Ile Asn Glu Leu Asp Tyr 
            100                 105                 110         

Tyr Leu Val Ser His Phe His Ser Asp His Ile Asp Pro Tyr Thr Ala 
        115                 120                 125             

Ala Ala Ile Leu Asn Asn Pro Lys Leu Glu His Val Lys Phe Ile Gly 
    130                 135                 140                 

Pro Tyr His Cys Gly Arg Ile Trp Glu Gly Trp Gly Val Pro Lys Glu 
145                 150                 155                 160 

Arg Ile Ile Val Val Lys Pro Gly Asp Thr Ile Glu Leu Lys Asp Met 
                165                 170                 175     

Lys Ile His Ala Val Glu Ser Phe Asp Arg Thr Cys Leu Val Thr Leu 
            180                 185                 190         

Pro Val Asn Gly Ala Asp Glu Thr Gly Gly Glu Leu Ala Gly Leu Ala 
        195                 200                 205             

Val Thr Asp Glu Glu Met Ala Gln Lys Ala Val Asn Tyr Ile Phe Glu 
    210                 215                 220                 

Thr Pro Gly Gly Thr Ile Tyr His Gly Ala Asp Ser His Phe Ser Asn 
225                 230                 235                 240 

Tyr Phe Ala Lys His Gly Lys Asp Phe Lys Ile Asp Val Ala Leu Asn 
                245                 250                 255     

Asn Tyr Gly Glu Asn Pro Val Gly Ile Gln Asp Lys Met Thr Ser Ile 
            260                 265                 270         

Asp Leu Leu Arg Met Ala Glu Asn Leu Arg Thr Lys Val Ile Ile Pro 
        275                 280                 285             

Val His Tyr Asp Ile Trp Ser Asn Phe Met Ala Ser Thr Asn Glu Ile 
    290                 295                 300                 

Leu Glu Leu Trp Lys Met Arg Lys Asp Arg Leu Gln Tyr Asp Phe His 
305                 310                 315                 320 

Pro Phe Ile Trp Glu Val Gly Gly Lys Tyr Thr Tyr Pro Gln Asp Gln 
                325                 330                 335     

His Leu Val Glu Tyr His His Pro Arg Gly Phe Asp Asp Cys Phe Glu 
            340                 345                 350         

Gln Asp Ser Asn Ile Gln Phe Lys Ala Leu Leu 
        355                 360             

<210>   4233
<211>   1671
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4233
atggtactgg ataaggcaag ttgtgatttg cttcaatatt tgatggatca agaaacgtcc   60
aaaacgatta tggcgatttc gaaagatttg aaagagtcaa gaaggaaaat ttattatcac   120
attgacaaaa tcaatgctgc tctgggtgac gaggcgcttc acatcattag tattccacga   180
attggtattc acttaacgga agagcagaga gatgcttgtt gtaaactatt atcggaagta   240
gattcgtacg attatatcat gagtgcgcat gaacgtatga tgataatgtt actatggata   300
ggtatttcta aagaacgtat tacgattgaa aaattgatag agttaacaga ggtatctagg   360
aatactgttc tcaatgattt gaatagtatt cgttatcaac taactttgga acaatatcag   420
gtgatcttgc aagtgagcaa gtcacaggga tacaaccttc atgcccaccc tcttaataaa   480
attcagtatc ttcaatcgct tctatatcat atttttatgg aagaaaatgc cacttttgta   540
tctattttag aagataagat gaaagagagg ttagatgatg agtgtttgct ttctgttgaa   600
atgaaccaat tttttaagga acaggttcct ttagttgaac aagatttagg gaagaaaata   660
aaccatcatg aaataacttt tatgttgcag gttctacctt atttgctgtt aagctgtcat   720
aatgttgaac agtatcaaga aagacatcag gatatagaga aagaattttc tttgataaga   780
aaaagaatag agtatcaggt gtctaagaaa ttaggagaac ggttgtttca aaagtttgaa   840
atttctttgt caggacttga agtttctctt gtagctgttc tcctcctctc ctatcgtaaa   900
gatttggata ttcatgcaga aagtgatgat tttcggcaat taaaacttgc tttagaagaa   960
tttatctggt attttgaatc acaaatccga atggagattg agaacaagga tgatttgtta   1020
cgaaatttga tgatccactg taaagccttg ttatttagaa agacttacgg tattttttct   1080
aaaaatcctc taacaaaaca aattcgatcc aagtatggag aattattttt agtcactaga   1140
aaatctgcgg aaattttaga aggagcatgg tttattcggc taacagacga tgatattgcc   1200
tatttgacga ttcatattgg aggattttta aaatatacac catcatctca aaaaaatatg   1260
aaaaaagttt atctcgtttg tgatgaaggt gttgcggttt cgagactttt gctgaaacaa   1320
tgcaaacttt attttccaaa tgagcaaatt gacactgtat ttacaacaga acaatttaag   1380
agtgtggaag atattgcaca agttgatgta gtgattacta ctaatgatga tttggatagc   1440
agatttccga ttttaagggt taatcctatc cttgaagcag aagatatttt gaaaatgcta   1500
gactatctta aacacaatat atttcgtaat aagagcaaaa gtttcagtga aaatctttct   1560
agtcttattt cgtcttatat tgtagacagc aagttggcta gtaagttcca agaagaggtt   1620
caaacactta taaatcaaga aatagtagtt caagcttttt tggaagatat t            1671

<210>   4234
<211>   557
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, BglG family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903885 (0.E+01)

<400>   4234
Met Val Leu Asp Lys Ala Ser Cys Asp Leu Leu Gln Tyr Leu Met Asp 
1               5                   10                  15      

Gln Glu Thr Ser Lys Thr Ile Met Ala Ile Ser Lys Asp Leu Lys Glu 
            20                  25                  30          

Ser Arg Arg Lys Ile Tyr Tyr His Ile Asp Lys Ile Asn Ala Ala Leu 
        35                  40                  45              

Gly Asp Glu Ala Leu His Ile Ile Ser Ile Pro Arg Ile Gly Ile His 
    50                  55                  60                  

Leu Thr Glu Glu Gln Arg Asp Ala Cys Cys Lys Leu Leu Ser Glu Val 
65                  70                  75                  80  

Asp Ser Tyr Asp Tyr Ile Met Ser Ala His Glu Arg Met Met Ile Met 
                85                  90                  95      

Leu Leu Trp Ile Gly Ile Ser Lys Glu Arg Ile Thr Ile Glu Lys Leu 
            100                 105                 110         

Ile Glu Leu Thr Glu Val Ser Arg Asn Thr Val Leu Asn Asp Leu Asn 
        115                 120                 125             

Ser Ile Arg Tyr Gln Leu Thr Leu Glu Gln Tyr Gln Val Ile Leu Gln 
    130                 135                 140                 

Val Ser Lys Ser Gln Gly Tyr Asn Leu His Ala His Pro Leu Asn Lys 
145                 150                 155                 160 

Ile Gln Tyr Leu Gln Ser Leu Leu Tyr His Ile Phe Met Glu Glu Asn 
                165                 170                 175     

Ala Thr Phe Val Ser Ile Leu Glu Asp Lys Met Lys Glu Arg Leu Asp 
            180                 185                 190         

Asp Glu Cys Leu Leu Ser Val Glu Met Asn Gln Phe Phe Lys Glu Gln 
        195                 200                 205             

Val Pro Leu Val Glu Gln Asp Leu Gly Lys Lys Ile Asn His His Glu 
    210                 215                 220                 

Ile Thr Phe Met Leu Gln Val Leu Pro Tyr Leu Leu Leu Ser Cys His 
225                 230                 235                 240 

Asn Val Glu Gln Tyr Gln Glu Arg His Gln Asp Ile Glu Lys Glu Phe 
                245                 250                 255     

Ser Leu Ile Arg Lys Arg Ile Glu Tyr Gln Val Ser Lys Lys Leu Gly 
            260                 265                 270         

Glu Arg Leu Phe Gln Lys Phe Glu Ile Ser Leu Ser Gly Leu Glu Val 
        275                 280                 285             

Ser Leu Val Ala Val Leu Leu Leu Ser Tyr Arg Lys Asp Leu Asp Ile 
    290                 295                 300                 

His Ala Glu Ser Asp Asp Phe Arg Gln Leu Lys Leu Ala Leu Glu Glu 
305                 310                 315                 320 

Phe Ile Trp Tyr Phe Glu Ser Gln Ile Arg Met Glu Ile Glu Asn Lys 
                325                 330                 335     

Asp Asp Leu Leu Arg Asn Leu Met Ile His Cys Lys Ala Leu Leu Phe 
            340                 345                 350         

Arg Lys Thr Tyr Gly Ile Phe Ser Lys Asn Pro Leu Thr Lys Gln Ile 
        355                 360                 365             

Arg Ser Lys Tyr Gly Glu Leu Phe Leu Val Thr Arg Lys Ser Ala Glu 
    370                 375                 380                 

Ile Leu Glu Gly Ala Trp Phe Ile Arg Leu Thr Asp Asp Asp Ile Ala 
385                 390                 395                 400 

Tyr Leu Thr Ile His Ile Gly Gly Phe Leu Lys Tyr Thr Pro Ser Ser 
                405                 410                 415     

Gln Lys Asn Met Lys Lys Val Tyr Leu Val Cys Asp Glu Gly Val Ala 
            420                 425                 430         

Val Ser Arg Leu Leu Leu Lys Gln Cys Lys Leu Tyr Phe Pro Asn Glu 
        435                 440                 445             

Gln Ile Asp Thr Val Phe Thr Thr Glu Gln Phe Lys Ser Val Glu Asp 
    450                 455                 460                 

Ile Ala Gln Val Asp Val Val Ile Thr Thr Asn Asp Asp Leu Asp Ser 
465                 470                 475                 480 

Arg Phe Pro Ile Leu Arg Val Asn Pro Ile Leu Glu Ala Glu Asp Ile 
                485                 490                 495     

Leu Lys Met Leu Asp Tyr Leu Lys His Asn Ile Phe Arg Asn Lys Ser 
            500                 505                 510         

Lys Ser Phe Ser Glu Asn Leu Ser Ser Leu Ile Ser Ser Tyr Ile Val 
        515                 520                 525             

Asp Ser Lys Leu Ala Ser Lys Phe Gln Glu Glu Val Gln Thr Leu Ile 
    530                 535                 540                 

Asn Gln Glu Ile Val Val Gln Ala Phe Leu Glu Asp Ile 
545                 550                 555         

<210>   4235
<211>   681
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4235
atgcgtaaac gagtctgtga tgccaatcaa tcattgccaa aacatggact tgtcaaattt   60
acctggggga atgtatctga agttaatcgc gaactcggtg tcattgttat caaaccatca   120
ggcgtggatt atgacgaatt gacacctgaa aacatggtag tgactgatct agatggtaag   180
atcctagaag gggatttaag accatcttcc gacctcccaa ctcatgtgca attatataag   240
acttggtcag aaattggtag tgtggttcac acccattcga cagaagctgt tggttgggct   300
caggcaggtc gtgatattcc tttctacgga acaacccatg cagattattt ctacggttca   360
atcccttgcg cccgtagttt gaccaaggac gaagtagaag tggcctatga aaaagatact   420
ggcctggtta tcgtagaaga gtttgaacat cgcggactta acccggttga agtaccagga   480
attgttgtac gcaatcacgg tccattcacc tggggcaaaa atccagagaa tgctgtttat   540
cactctgtcg tactagagga agtatcaaag atgaatcgct ttacagaaca aatcaatcca   600
agagttggac ctgctcccca gtacatacta gaaaaacact accaacgtaa acatggacca   660
aatgcttatt atggtcaaaa g                                             681

<210>   4236
<211>   227
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   L-ribulose 5-phosphate 4-epimerase AraD, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903886 (e-135)

<400>   4236
Met Arg Lys Arg Val Cys Asp Ala Asn Gln Ser Leu Pro Lys His Gly 
1               5                   10                  15      

Leu Val Lys Phe Thr Trp Gly Asn Val Ser Glu Val Asn Arg Glu Leu 
            20                  25                  30          

Gly Val Ile Val Ile Lys Pro Ser Gly Val Asp Tyr Asp Glu Leu Thr 
        35                  40                  45              

Pro Glu Asn Met Val Val Thr Asp Leu Asp Gly Lys Ile Leu Glu Gly 
    50                  55                  60                  

Asp Leu Arg Pro Ser Ser Asp Leu Pro Thr His Val Gln Leu Tyr Lys 
65                  70                  75                  80  

Thr Trp Ser Glu Ile Gly Ser Val Val His Thr His Ser Thr Glu Ala 
                85                  90                  95      

Val Gly Trp Ala Gln Ala Gly Arg Asp Ile Pro Phe Tyr Gly Thr Thr 
            100                 105                 110         

His Ala Asp Tyr Phe Tyr Gly Ser Ile Pro Cys Ala Arg Ser Leu Thr 
        115                 120                 125             

Lys Asp Glu Val Glu Val Ala Tyr Glu Lys Asp Thr Gly Leu Val Ile 
    130                 135                 140                 

Val Glu Glu Phe Glu His Arg Gly Leu Asn Pro Val Glu Val Pro Gly 
145                 150                 155                 160 

Ile Val Val Arg Asn His Gly Pro Phe Thr Trp Gly Lys Asn Pro Glu 
                165                 170                 175     

Asn Ala Val Tyr His Ser Val Val Leu Glu Glu Val Ser Lys Met Asn 
            180                 185                 190         

Arg Phe Thr Glu Gln Ile Asn Pro Arg Val Gly Pro Ala Pro Gln Tyr 
        195                 200                 205             

Ile Leu Glu Lys His Tyr Gln Arg Lys His Gly Pro Asn Ala Tyr Tyr 
    210                 215                 220                 

Gly Gln Lys 
225         

<210>   4237
<211>   861
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4237
atggtacgtc caattggaat ttatgaaaag gcaaccccaa cacactgtac ttggctagaa   60
cgtttaaatt ttgccaagga gttaggcttt gattttgtcg agatgtctat tgacgaacgt   120
gacgagcgtt tagcaagact tgactggagt aaggaagaac gcttggaagt tgtcaaagca   180
atctatgaaa ctggtgttcg tattccttct atctgttttt caggccatcg tcgctaccca   240
ttgggttcaa aagatccagt tctagaggaa aaatctctag aactcatgaa aaaatgtatc   300
gaattagctc aagacttggg agttcgtacg attcaattag ctggttacga tgtttactat   360
gaggaaaagt caccccagac acgccaacgt tttatcaaaa atttgagaaa agcctgtgac   420
tgggctgaag aagctcaggt ggtacttgct attgaaatta tggatgatcc tttcatcagt   480
agcatcgaaa aatatttggc tatagaaaaa gagattgact ctcccttcct ctttgtatat   540
ccagatattg gtaatgtgtc tgcatggcat aatgatatct atagtgagtt ttatcttggt   600
catcatgcca tcgcagctct ccatctcaag gatacttatg cagtgacaga aagttcaaag   660
ggccagttcc gagatgtacc tttcgggcaa ggttgtgtca aatgggaaga agctttcgat   720
attttaaagg aaaccaatta taatggacct ttcctaatcg aaatgtggtc tgaaaattgt   780
gaaacagtag aagaaacacg cgcagccatt caagaggcgc aagcttttct ctatccactc   840
attaagaaag caggtttgat g                                             861

<210>   4238
<211>   287
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hexulose-6-phosphate isomerase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903887 (e-168)

<400>   4238
Met Val Arg Pro Ile Gly Ile Tyr Glu Lys Ala Thr Pro Thr His Cys 
1               5                   10                  15      

Thr Trp Leu Glu Arg Leu Asn Phe Ala Lys Glu Leu Gly Phe Asp Phe 
            20                  25                  30          

Val Glu Met Ser Ile Asp Glu Arg Asp Glu Arg Leu Ala Arg Leu Asp 
        35                  40                  45              

Trp Ser Lys Glu Glu Arg Leu Glu Val Val Lys Ala Ile Tyr Glu Thr 
    50                  55                  60                  

Gly Val Arg Ile Pro Ser Ile Cys Phe Ser Gly His Arg Arg Tyr Pro 
65                  70                  75                  80  

Leu Gly Ser Lys Asp Pro Val Leu Glu Glu Lys Ser Leu Glu Leu Met 
                85                  90                  95      

Lys Lys Cys Ile Glu Leu Ala Gln Asp Leu Gly Val Arg Thr Ile Gln 
            100                 105                 110         

Leu Ala Gly Tyr Asp Val Tyr Tyr Glu Glu Lys Ser Pro Gln Thr Arg 
        115                 120                 125             

Gln Arg Phe Ile Lys Asn Leu Arg Lys Ala Cys Asp Trp Ala Glu Glu 
    130                 135                 140                 

Ala Gln Val Val Leu Ala Ile Glu Ile Met Asp Asp Pro Phe Ile Ser 
145                 150                 155                 160 

Ser Ile Glu Lys Tyr Leu Ala Ile Glu Lys Glu Ile Asp Ser Pro Phe 
                165                 170                 175     

Leu Phe Val Tyr Pro Asp Ile Gly Asn Val Ser Ala Trp His Asn Asp 
            180                 185                 190         

Ile Tyr Ser Glu Phe Tyr Leu Gly His His Ala Ile Ala Ala Leu His 
        195                 200                 205             

Leu Lys Asp Thr Tyr Ala Val Thr Glu Ser Ser Lys Gly Gln Phe Arg 
    210                 215                 220                 

Asp Val Pro Phe Gly Gln Gly Cys Val Lys Trp Glu Glu Ala Phe Asp 
225                 230                 235                 240 

Ile Leu Lys Glu Thr Asn Tyr Asn Gly Pro Phe Leu Ile Glu Met Trp 
                245                 250                 255     

Ser Glu Asn Cys Glu Thr Val Glu Glu Thr Arg Ala Ala Ile Gln Glu 
            260                 265                 270         

Ala Gln Ala Phe Leu Tyr Pro Leu Ile Lys Lys Ala Gly Leu Met 
        275                 280                 285         

<210>   4239
<211>   663
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4239
atgacaaaaa gaatacctaa tttacaagtt gcattagacc attcagactt gcaaggagcg   60
attaaagcag ctgtttctgt tggtcaggaa gtagatatta tcgaagctgg aactgtttgc   120
ttgcttcaag ttggaagtga actggctgaa gtcttgcgta gccttttccc agataagatt   180
attgtggcag acacaaaatg tgctgatgct ggtggaacag ttgctaaaaa taatgcggtt   240
cgtggagcag actggatgac ttgtatctgt tgtgcaacca tccctactat ggaagcagct   300
ctaaaggcta tcaagactga acgaggagaa cgaggcgaaa tccagatcga gctttatggc   360
gattggactt ttgaacaagc tcagctttgg ctagatgcag gtatctcaca agctatttat   420
caccaatctc gtgatgctct tcttgctggt gaaacttggg gtgaaaaaga ccttaataag   480
gttaaaaaac tcattgacat gggcttccgt gtatctgtaa caggtggtct agatgtagat   540
actctcaaac tctttgaagg tattgatgtc tttaccttta tcgcaggtcg tggaattaca   600
gaggctgtgg atccagcagg agcagcgcgt gccttcaagg atgaaatcaa acgaatttgg   660
ggg                                                                 663

<210>   4240
<211>   221
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hexulose-6-phosphate synthase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903888 (e-125)

<400>   4240
Met Thr Lys Arg Ile Pro Asn Leu Gln Val Ala Leu Asp His Ser Asp 
1               5                   10                  15      

Leu Gln Gly Ala Ile Lys Ala Ala Val Ser Val Gly Gln Glu Val Asp 
            20                  25                  30          

Ile Ile Glu Ala Gly Thr Val Cys Leu Leu Gln Val Gly Ser Glu Leu 
        35                  40                  45              

Ala Glu Val Leu Arg Ser Leu Phe Pro Asp Lys Ile Ile Val Ala Asp 
    50                  55                  60                  

Thr Lys Cys Ala Asp Ala Gly Gly Thr Val Ala Lys Asn Asn Ala Val 
65                  70                  75                  80  

Arg Gly Ala Asp Trp Met Thr Cys Ile Cys Cys Ala Thr Ile Pro Thr 
                85                  90                  95      

Met Glu Ala Ala Leu Lys Ala Ile Lys Thr Glu Arg Gly Glu Arg Gly 
            100                 105                 110         

Glu Ile Gln Ile Glu Leu Tyr Gly Asp Trp Thr Phe Glu Gln Ala Gln 
        115                 120                 125             

Leu Trp Leu Asp Ala Gly Ile Ser Gln Ala Ile Tyr His Gln Ser Arg 
    130                 135                 140                 

Asp Ala Leu Leu Ala Gly Glu Thr Trp Gly Glu Lys Asp Leu Asn Lys 
145                 150                 155                 160 

Val Lys Lys Leu Ile Asp Met Gly Phe Arg Val Ser Val Thr Gly Gly 
                165                 170                 175     

Leu Asp Val Asp Thr Leu Lys Leu Phe Glu Gly Ile Asp Val Phe Thr 
            180                 185                 190         

Phe Ile Ala Gly Arg Gly Ile Thr Glu Ala Val Asp Pro Ala Gly Ala 
        195                 200                 205             

Ala Arg Ala Phe Lys Asp Glu Ile Lys Arg Ile Trp Gly 
    210                 215                 220     

<210>   4241
<211>   483
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4241
atgaatttaa aacaagcttt aattgacaat gactcgatcc gactaggttt agaggctaac   60
aattggaaag aagcagtcaa ggtagcagta gatcccttaa ttgaaagtgg ggcaattttg   120
ccagagtatt acgatgctat cattgaatcg actgaagagt atgggcctta ctatatcttg   180
atgccaggta tggctatgcc ccacgctaga cctgaagcag gtgtgcaaag tgatgccttt   240
tcattgatta ccttacaaaa tcctgttgta ttttcagatg ggaaagaggt atctgttttg   300
ttggcactag cagcaacaag ttcaaaaatt cacacaagtg tagccattcc acaaattatt   360
gccctatttg aattagaaga ttctattgca cgtttacagg cttgccagac taaagaagat   420
gtcttggcta tgattgaaga atctaaggat agcccttatc tcgaaggatt ggatttggaa   480
agt                                                                 483

<210>   4242
<211>   161
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIA component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903889 (3.E-87)

<400>   4242
Met Asn Leu Lys Gln Ala Leu Ile Asp Asn Asp Ser Ile Arg Leu Gly 
1               5                   10                  15      

Leu Glu Ala Asn Asn Trp Lys Glu Ala Val Lys Val Ala Val Asp Pro 
            20                  25                  30          

Leu Ile Glu Ser Gly Ala Ile Leu Pro Glu Tyr Tyr Asp Ala Ile Ile 
        35                  40                  45              

Glu Ser Thr Glu Glu Tyr Gly Pro Tyr Tyr Ile Leu Met Pro Gly Met 

    50                  55                  60                  

Ala Met Pro His Ala Arg Pro Glu Ala Gly Val Gln Ser Asp Ala Phe 
65                  70                  75                  80  

Ser Leu Ile Thr Leu Gln Asn Pro Val Val Phe Ser Asp Gly Lys Glu 
                85                  90                  95      

Val Ser Val Leu Leu Ala Leu Ala Ala Thr Ser Ser Lys Ile His Thr 
            100                 105                 110         

Ser Val Ala Ile Pro Gln Ile Ile Ala Leu Phe Glu Leu Glu Asp Ser 
        115                 120                 125             

Ile Ala Arg Leu Gln Ala Cys Gln Thr Lys Glu Asp Val Leu Ala Met 
    130                 135                 140                 

Ile Glu Glu Ser Lys Asp Ser Pro Tyr Leu Glu Gly Leu Asp Leu Glu 
145                 150                 155                 160 

Ser 
    

<210>   4243
<211>   279
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4243
atggttaaag tattagcagc gtgcggaaat ggaatgggtt catcaatggt tatcaagatg   60
aaggttgaaa atgctctccg taagcttaat caaacagatt ttacagtcaa ttcatgcagt   120
gtcggtgaag ctaaaggttt agcagtagga tatgacatcg taatcgcttc tcttcatttg   180
attcaagaat tggaagggcg aactaatggg aagttaattg ggcttgataa cttgatggat   240
gataaagaaa tcaccgaaaa actcagtcaa gcactacag                          279

<210>   4244
<211>   93
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIB component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903890 (5.E-48)

<400>   4244
Met Val Lys Val Leu Ala Ala Cys Gly Asn Gly Met Gly Ser Ser Met 
1               5                   10                  15      

Val Ile Lys Met Lys Val Glu Asn Ala Leu Arg Lys Leu Asn Gln Thr 
            20                  25                  30          

Asp Phe Thr Val Asn Ser Cys Ser Val Gly Glu Ala Lys Gly Leu Ala 
        35                  40                  45              

Val Gly Tyr Asp Ile Val Ile Ala Ser Leu His Leu Ile Gln Glu Leu 
    50                  55                  60                  

Glu Gly Arg Thr Asn Gly Lys Leu Ile Gly Leu Asp Asn Leu Met Asp 
65                  70                  75                  80  

Asp Lys Glu Ile Thr Glu Lys Leu Ser Gln Ala Leu Gln 
                85                  90              

<210>   4245
<211>   1524
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4245
ttggtctttt tgtttgcgct ttcgcattat ataataaact tacaaaaaca attcaaaagg   60
agaacaatta tggaagtcgt ttcaagtgtt ctaaattggt tttctagcaa tattttgcag   120
aatcccgcat ttttcgtagg tttattggtg ttgataggat atgcactttt gaaaaaacct   180
gcccatgacg ttttttcagg gtttgttaaa gcaacagtag ggtatatgtt gcttaacgtg   240
ggtgctggtg gtttggttac aacctttcgt ccaatcttag cagctcttaa ctacaaattc   300
caaattggtg cagcggttat cgacccttac tttggacttg ctgcagcaaa caacaaaatt   360
gtagcagagt ttccagattt tgttggaact gcaactacag ctctattgat tggttttgga   420
ataaatatct tgctcgtagc tcttcgaaag attacgaagg taagaaccct ctttattact   480
ggtcacatca tggtacaaca agctgcaaca gtatctctta tggttctatt cttagtacca   540
caattgcgca atgcttacgg tacagcagcg attggtatca tctgtggact ttactgggca   600
gttagttcaa atatgactgt tgaggcaact caacgcttga ctggtggtgg cggatttgcg   660
attggtcacc aacagcaatt tgcaatctgg tttgtagata aagtagcagg acgctttggt   720
aagaaagaag aaagtttaga caatcttaaa ttacctaagt tcctctcaat cttccacgat   780
acagttgttg catctgctac cttgatgctc gtattcttcg gagccattct tttaatcttg   840
ggtccagaca ttatgtctaa taaagaagtc atcacttcag gaactctatt caatcctgct   900
aaacaagatt tctttatgta cattatccaa acagccttta ccttctcagt ttacttgttc   960
gttttgatgc aaggtgtccg aatgttcgta tctgagttga caaacgcctt ccaaggtatt   1020
tcaaacaaat tgttgccagg ttcattccca gcggttgacg ttgcagcttc ttatggattt   1080
ggttctccaa atgctgtctt gtcaggattt acctttggtt tgattggtca attgattaca   1140
attgttttgc tcatcgtctt taaaaatccg attcttatta ttacaggatt tgtaccagtg   1200
ttctttgaca atgcagccat tgcggtctac gctgataaac gcggcggatg gaaagcggct   1260
gttatccttt cctttatatc aggtgtcctt caagttgctc taggagctct ttgtgtggcc   1320
cttctcgatt tggcatctta tggtggctac catggaaata tcgactttga attcccatgg   1380
cttggatttg gatatatctt caaatacctt ggtattgttg gttatgtact tgtgtgtctc   1440
ttcttgcttg ttattcctca acttcaattt gccaaagcaa aagataaaga gaaatattac   1500
aacggtgaag ttcaagaaga agct                                          1524

<210>   4246
<211>   508
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, membrane component, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903891 (0.E+01)

<400>   4246
Met Val Phe Leu Phe Ala Leu Ser His Tyr Ile Ile Asn Leu Gln Lys 
1               5                   10                  15      

Gln Phe Lys Arg Arg Thr Ile Met Glu Val Val Ser Ser Val Leu Asn 
            20                  25                  30          

Trp Phe Ser Ser Asn Ile Leu Gln Asn Pro Ala Phe Phe Val Gly Leu 
        35                  40                  45              

Leu Val Leu Ile Gly Tyr Ala Leu Leu Lys Lys Pro Ala His Asp Val 
    50                  55                  60                  

Phe Ser Gly Phe Val Lys Ala Thr Val Gly Tyr Met Leu Leu Asn Val 
65                  70                  75                  80  

Gly Ala Gly Gly Leu Val Thr Thr Phe Arg Pro Ile Leu Ala Ala Leu 
                85                  90                  95      

Asn Tyr Lys Phe Gln Ile Gly Ala Ala Val Ile Asp Pro Tyr Phe Gly 
            100                 105                 110         

Leu Ala Ala Ala Asn Asn Lys Ile Val Ala Glu Phe Pro Asp Phe Val 
        115                 120                 125             

Gly Thr Ala Thr Thr Ala Leu Leu Ile Gly Phe Gly Ile Asn Ile Leu 
    130                 135                 140                 

Leu Val Ala Leu Arg Lys Ile Thr Lys Val Arg Thr Leu Phe Ile Thr 
145                 150                 155                 160 

Gly His Ile Met Val Gln Gln Ala Ala Thr Val Ser Leu Met Val Leu 
                165                 170                 175     

Phe Leu Val Pro Gln Leu Arg Asn Ala Tyr Gly Thr Ala Ala Ile Gly 
            180                 185                 190         

Ile Ile Cys Gly Leu Tyr Trp Ala Val Ser Ser Asn Met Thr Val Glu 
        195                 200                 205             


Ala Thr Gln Arg Leu Thr Gly Gly Gly Gly Phe Ala Ile Gly His Gln 
    210                 215                 220                 

Gln Gln Phe Ala Ile Trp Phe Val Asp Lys Val Ala Gly Arg Phe Gly 
225                 230                 235                 240 

Lys Lys Glu Glu Ser Leu Asp Asn Leu Lys Leu Pro Lys Phe Leu Ser 
                245                 250                 255     

Ile Phe His Asp Thr Val Val Ala Ser Ala Thr Leu Met Leu Val Phe 
            260                 265                 270         

Phe Gly Ala Ile Leu Leu Ile Leu Gly Pro Asp Ile Met Ser Asn Lys 
        275                 280                 285             

Glu Val Ile Thr Ser Gly Thr Leu Phe Asn Pro Ala Lys Gln Asp Phe 
    290                 295                 300                 

Phe Met Tyr Ile Ile Gln Thr Ala Phe Thr Phe Ser Val Tyr Leu Phe 
305                 310                 315                 320 

Val Leu Met Gln Gly Val Arg Met Phe Val Ser Glu Leu Thr Asn Ala 
                325                 330                 335     

Phe Gln Gly Ile Ser Asn Lys Leu Leu Pro Gly Ser Phe Pro Ala Val 
            340                 345                 350         

Asp Val Ala Ala Ser Tyr Gly Phe Gly Ser Pro Asn Ala Val Leu Ser 
        355                 360                 365             

Gly Phe Thr Phe Gly Leu Ile Gly Gln Leu Ile Thr Ile Val Leu Leu 
    370                 375                 380                 

Ile Val Phe Lys Asn Pro Ile Leu Ile Ile Thr Gly Phe Val Pro Val 
385                 390                 395                 400 

Phe Phe Asp Asn Ala Ala Ile Ala Val Tyr Ala Asp Lys Arg Gly Gly 
                405                 410                 415     

Trp Lys Ala Ala Val Ile Leu Ser Phe Ile Ser Gly Val Leu Gln Val 
            420                 425                 430         

Ala Leu Gly Ala Leu Cys Val Ala Leu Leu Asp Leu Ala Ser Tyr Gly 
        435                 440                 445             

Gly Tyr His Gly Asn Ile Asp Phe Glu Phe Pro Trp Leu Gly Phe Gly 
    450                 455                 460                 

Tyr Ile Phe Lys Tyr Leu Gly Ile Val Gly Tyr Val Leu Val Cys Leu 
465                 470                 475                 480 

Phe Leu Leu Val Ile Pro Gln Leu Gln Phe Ala Lys Ala Lys Asp Lys 
                485                 490                 495     

Glu Lys Tyr Tyr Asn Gly Glu Val Gln Glu Glu Ala 
            500                 505             

<210>   4247
<211>   621
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4247
atgttgaata agataagaga ctatttagac tttgctggtt tgcagtaccg taatcctgat   60
aaagcgggag cagagcgaga gaagatgctg gcattccgcc acaaaggaca agaggcccga   120
aaggttttta cagaactggc caaagccttt caagcaagcc atccagaatg gcaactccaa   180
cagactagcc agtggatgaa tcaggcccag cgtttgagac cacatttttg ggtttatcta   240
cagagagacg gacaagtgac agaacctatg atggccttac gtttgtatgg gacatctact   300
gactttggaa tttctttgga agtcagtttc atcgaacgta agaaggatga gcaaacactg   360
ggcaagcagg ccaaagtttt agacattcca accgttaaag ggatttatta tctaacctac   420
tctaatggtc aaagtcaacg gtgggaggcg aatgaagaaa agcgtcgtac tttacgcgag   480
aaggtgagaa gtcaagaagt tcgaaaagtt ttagtgaagg tagatgttcc tatgacagaa   540
aattcgtctg aagaagaaat cgtagaaggc ttattgaagt cttattctaa aattcttccc   600
tattatctag ctacgagaaa a                                             621

<210>   4248
<211>   207
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903892 (e-118)

<400>   4248
Met Leu Asn Lys Ile Arg Asp Tyr Leu Asp Phe Ala Gly Leu Gln Tyr 
1               5                   10                  15      

Arg Asn Pro Asp Lys Ala Gly Ala Glu Arg Glu Lys Met Leu Ala Phe 
            20                  25                  30          

Arg His Lys Gly Gln Glu Ala Arg Lys Val Phe Thr Glu Leu Ala Lys 
        35                  40                  45              

Ala Phe Gln Ala Ser His Pro Glu Trp Gln Leu Gln Gln Thr Ser Gln 
    50                  55                  60                  

Trp Met Asn Gln Ala Gln Arg Leu Arg Pro His Phe Trp Val Tyr Leu 
65                  70                  75                  80  

Gln Arg Asp Gly Gln Val Thr Glu Pro Met Met Ala Leu Arg Leu Tyr 
                85                  90                  95      

Gly Thr Ser Thr Asp Phe Gly Ile Ser Leu Glu Val Ser Phe Ile Glu 
            100                 105                 110         

Arg Lys Lys Asp Glu Gln Thr Leu Gly Lys Gln Ala Lys Val Leu Asp 
        115                 120                 125             

Ile Pro Thr Val Lys Gly Ile Tyr Tyr Leu Thr Tyr Ser Asn Gly Gln 
    130                 135                 140                 

Ser Gln Arg Trp Glu Ala Asn Glu Glu Lys Arg Arg Thr Leu Arg Glu 
145                 150                 155                 160 

Lys Val Arg Ser Gln Glu Val Arg Lys Val Leu Val Lys Val Asp Val 
                165                 170                 175     

Pro Met Thr Glu Asn Ser Ser Glu Glu Glu Ile Val Glu Gly Leu Leu 
            180                 185                 190         

Lys Ser Tyr Ser Lys Ile Leu Pro Tyr Tyr Leu Ala Thr Arg Lys 
        195                 200                 205         

<210>   4249
<211>   984
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4249
gtggtagtat ttacaggttc aactgttgaa gaagcaatcc agaaaggatt gaaagaatta   60
gatattccaa gaatgaaggc tcatatcaaa gtcatttcta gggagaaaaa aggctttctt   120
ggtctatttg gtaaaaaacc agcccaagtg gatattgaag cgattagtga aacgactgtt   180
gtcaaagcaa atcaacaggt agtaaaaggc gttccgaaaa aaatcaatga tttgaacgag   240
cctgtgaaga cggttagtga agaaaccgtt gaccttggtc atgtggttga tgctattaaa   300
aaaatagagg aagaaggtca aggtatttct gatgaagtca aggctgaaat cttaaaacat   360
gaaagacatg ccagcactat cttagaagaa actggtcaca ttgagatttt aaatgaactt   420
caaatcgagg aagcgatgag ggaagaagca ggcgctgatg accttgaaac tgagcaagac   480
caagctgaaa gtcaagaact agaagacttg ggcttgaaag ttgaaacgaa ctttgatatt   540
gaacaagtag ctacggaagt aatggcttat gttcaaacga ttattgatga catggatgtt   600
gaggctacac tttcaaatga ttataaccgt cgtagcatca atctacaaat tgacaccaac   660
gaaccaggtc gtattatcgg ctaccatggt aaagtcttga aggccttgca actgttggct   720
caaaattatc tttacaaccg ctattccaga accttctacg ttacaatcaa tgtcaatgat   780
tatgtcgaac accgtgcaga agtcttgcag acctatgcgc aaaaattggc gactcgtgtt   840
ttggaagaag ggcgcagtca taaaacagat ccaatgtcaa atagcgaacg caagattatc   900
catcgtatta tttcacgtat ggatggcgtg actagttact ctgaaggtga tgagccaaat   960
cgctatgttg ttgtagatac agaa                                          984

<210>   4250
<211>   328
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   jag protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903893 (0.E+01)

<400>   4250
Met Val Val Phe Thr Gly Ser Thr Val Glu Glu Ala Ile Gln Lys Gly 
1               5                   10                  15      

Leu Lys Glu Leu Asp Ile Pro Arg Met Lys Ala His Ile Lys Val Ile 
            20                  25                  30          

Ser Arg Glu Lys Lys Gly Phe Leu Gly Leu Phe Gly Lys Lys Pro Ala 
        35                  40                  45              

Gln Val Asp Ile Glu Ala Ile Ser Glu Thr Thr Val Val Lys Ala Asn 
    50                  55                  60                  

Gln Gln Val Val Lys Gly Val Pro Lys Lys Ile Asn Asp Leu Asn Glu 
65                  70                  75                  80  

Pro Val Lys Thr Val Ser Glu Glu Thr Val Asp Leu Gly His Val Val 
                85                  90                  95      

Asp Ala Ile Lys Lys Ile Glu Glu Glu Gly Gln Gly Ile Ser Asp Glu 
            100                 105                 110         

Val Lys Ala Glu Ile Leu Lys His Glu Arg His Ala Ser Thr Ile Leu 
        115                 120                 125             

Glu Glu Thr Gly His Ile Glu Ile Leu Asn Glu Leu Gln Ile Glu Glu 
    130                 135                 140                 

Ala Met Arg Glu Glu Ala Gly Ala Asp Asp Leu Glu Thr Glu Gln Asp 
145                 150                 155                 160 

Gln Ala Glu Ser Gln Glu Leu Glu Asp Leu Gly Leu Lys Val Glu Thr 
                165                 170                 175     

Asn Phe Asp Ile Glu Gln Val Ala Thr Glu Val Met Ala Tyr Val Gln 
            180                 185                 190         

Thr Ile Ile Asp Asp Met Asp Val Glu Ala Thr Leu Ser Asn Asp Tyr 
        195                 200                 205             

Asn Arg Arg Ser Ile Asn Leu Gln Ile Asp Thr Asn Glu Pro Gly Arg 
    210                 215                 220                 

Ile Ile Gly Tyr His Gly Lys Val Leu Lys Ala Leu Gln Leu Leu Ala 
225                 230                 235                 240 

Gln Asn Tyr Leu Tyr Asn Arg Tyr Ser Arg Thr Phe Tyr Val Thr Ile 
                245                 250                 255     

Asn Val Asn Asp Tyr Val Glu His Arg Ala Glu Val Leu Gln Thr Tyr 
            260                 265                 270         

Ala Gln Lys Leu Ala Thr Arg Val Leu Glu Glu Gly Arg Ser His Lys 
        275                 280                 285             

Thr Asp Pro Met Ser Asn Ser Glu Arg Lys Ile Ile His Arg Ile Ile 
    290                 295                 300                 

Ser Arg Met Asp Gly Val Thr Ser Tyr Ser Glu Gly Asp Glu Pro Asn 
305                 310                 315                 320 

Arg Tyr Val Val Val Asp Thr Glu 
                325             

<210>   4251
<211>   828
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4251
atgggagtga aaaagaaact aaagttgact agtttgctag gactgtctct gttaatcatg   60
acagcctgtg cgactaatgg ggtaactagc gatattacag ccgaatcggc tgatttttgg   120
agtaaattgg tttacttctt tgcggaaatc attcgctttt tatcgtttga tattagtatc   180
ggagtgggga ttattctctt tacggtcttg attcgtacag tcctcttgcc agtctttcag   240
gtgcaaatgg tggcttctag gaaaatgcag gaagctcagc cacgcattaa ggcgcttcga   300
gaacaatatc caggtcgaga tatggaaagc agaaccaaac tagagcagga aatgcgtaaa   360
gtatttaaag aaatgggtgt cagacagtca gactctcttt ggccgatttt gattcagatg   420
ccggttattt tggccctgtt ccaagcccta tcaagagttg actttttaaa gacaggtcat   480
ttcttatgga ttaaccttgg tagtgtggat acaacccttg ttcttccgat tttagcagca   540
gtattcacct ttttaagtac ttggttgtcc aacaaagctt tgtctgagcg aaatggcgct   600
acgactgcga tgatgtatgg gattccagtc ttgattttta tctttgcagt ttatgcgcca   660
ggtggagtcg ccctatactg gacagtgtct aatgcttatc aagtcttgca aacctatttc   720
ttgaataatc cattcaagat tatcgcagag cgcgaggccg tagtacaggc acaaaaagat   780
ttggaaaata gaaaaagaaa agccaagaaa aaggctcaga aaacgaaa                828

<210>   4252
<211>   276
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   inner membrane protein, 60 kDa
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903894 (e-152)

<400>   4252
Met Gly Val Lys Lys Lys Leu Lys Leu Thr Ser Leu Leu Gly Leu Ser 
1               5                   10                  15      

Leu Leu Ile Met Thr Ala Cys Ala Thr Asn Gly Val Thr Ser Asp Ile 
            20                  25                  30          

Thr Ala Glu Ser Ala Asp Phe Trp Ser Lys Leu Val Tyr Phe Phe Ala 
        35                  40                  45              

Glu Ile Ile Arg Phe Leu Ser Phe Asp Ile Ser Ile Gly Val Gly Ile 
    50                  55                  60                  

Ile Leu Phe Thr Val Leu Ile Arg Thr Val Leu Leu Pro Val Phe Gln 
65                  70                  75                  80  

Val Gln Met Val Ala Ser Arg Lys Met Gln Glu Ala Gln Pro Arg Ile 
                85                  90                  95      

Lys Ala Leu Arg Glu Gln Tyr Pro Gly Arg Asp Met Glu Ser Arg Thr 
            100                 105                 110         

Lys Leu Glu Gln Glu Met Arg Lys Val Phe Lys Glu Met Gly Val Arg 
        115                 120                 125             

Gln Ser Asp Ser Leu Trp Pro Ile Leu Ile Gln Met Pro Val Ile Leu 
    130                 135                 140                 

Ala Leu Phe Gln Ala Leu Ser Arg Val Asp Phe Leu Lys Thr Gly His 
145                 150                 155                 160 

Phe Leu Trp Ile Asn Leu Gly Ser Val Asp Thr Thr Leu Val Leu Pro 
                165                 170                 175     

Ile Leu Ala Ala Val Phe Thr Phe Leu Ser Thr Trp Leu Ser Asn Lys 
            180                 185                 190         

Ala Leu Ser Glu Arg Asn Gly Ala Thr Thr Ala Met Met Tyr Gly Ile 
        195                 200                 205             

Pro Val Leu Ile Phe Ile Phe Ala Val Tyr Ala Pro Gly Gly Val Ala 
    210                 215                 220                 

Leu Tyr Trp Thr Val Ser Asn Ala Tyr Gln Val Leu Gln Thr Tyr Phe 
225                 230                 235                 240 

Leu Asn Asn Pro Phe Lys Ile Ile Ala Glu Arg Glu Ala Val Val Gln 
                245                 250                 255     

Ala Gln Lys Asp Leu Glu Asn Arg Lys Arg Lys Ala Lys Lys Lys Ala 
            260                 265                 270         

Gln Lys Thr Lys 
        275     

<210>   4253
<211>   369
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4253
ttgaagaaaa actttcgtgt aaaaagagag aaagatttta aggcgatttt caaggagggg   60
acaagttttg ctaatcgcaa atttgtggtc taccaattag aaaaccagaa aaaccgtttt   120
cgagtaggtc tatcagttag caaaaaactg gggaatgccg tcactagaaa tcaaattaag   180
cgacggattc ggcatattat ccagaatgca aaagggagtc tggtagaaga tgtcgacttt   240
gttgtcattg ctcgaaaagg agtcgaaacc ttgggatacg cagagatgga gaaaaatcta   300
ctccatgtat taaaattatc aaagatttac cgggaaggaa atgggagtga aaaagaaact   360
aaagttgac                                                           369

<210>   4254
<211>   123
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribonuclease P protein component (rnpA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903895 (4.E-65)

<400>   4254
Met Lys Lys Asn Phe Arg Val Lys Arg Glu Lys Asp Phe Lys Ala Ile 
1               5                   10                  15      

Phe Lys Glu Gly Thr Ser Phe Ala Asn Arg Lys Phe Val Val Tyr Gln 
            20                  25                  30          

Leu Glu Asn Gln Lys Asn Arg Phe Arg Val Gly Leu Ser Val Ser Lys 
        35                  40                  45              

Lys Leu Gly Asn Ala Val Thr Arg Asn Gln Ile Lys Arg Arg Ile Arg 
    50                  55                  60                  

His Ile Ile Gln Asn Ala Lys Gly Ser Leu Val Glu Asp Val Asp Phe 
65                  70                  75                  80  

Val Val Ile Ala Arg Lys Gly Val Glu Thr Leu Gly Tyr Ala Glu Met 
                85                  90                  95      

Glu Lys Asn Leu Leu His Val Leu Lys Leu Ser Lys Ile Tyr Arg Glu 
            100                 105                 110         

Gly Asn Gly Ser Glu Lys Glu Thr Lys Val Asp 
        115                 120             

<210>   4255
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4255
gtgaaactaa aaaaatattc aatacaagga gttgggaaag ttatttttcc agcttctttt   60
tctgatgaaa ttgtccaaaa ccttgctatg attggctttt ttgaaaaata tggtataata   120
gtagtaatt                                                           129

<210>   4256
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4256
Met Lys Leu Lys Lys Tyr Ser Ile Gln Gly Val Gly Lys Val Ile Phe 
1               5                   10                  15      

Pro Ala Ser Phe Ser Asp Glu Ile Val Gln Asn Leu Ala Met Ile Gly 
            20                  25                  30          

Phe Phe Glu Lys Tyr Gly Ile Ile Val Val Ile 
        35                  40              

<210>   4257
<211>   1188
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4257
atgacaaaaa caattgcaat caatgcagga agttcaagtt tgaaatggca attatactta   60
atgccagaag aaaaagtatt ggcgaaaggt ttgattgaac gtatcggttt gaaagattca   120
atttcaactg taaaatttga cggccgttct gaacaacaaa ttttggatat tgaaaatcat   180
atacaagccg ttaaaatttt attggatgac ttgattcgtt tcgatattat caaggcttat   240
gacgagatta caggtgttgg acatcgtgtt gttgctggtg gagaatattt caaagaatca   300
acagttgttg agggagatgt tttagaaaaa gttgaagagt tgagtttgtt ggctcctcta   360
cacaacccgg ccaatgcagc aggtgttcgt gccttcaagg aattgttgcc agacattacc   420
agtgtagttg tttttgatac ttccttccac acaagtatgc cagagaaagc ttatcgctac   480
cctctaccaa caaaatatta cacagaaaac aaggttcgta aatacggtgc tcatggtaca   540
agtcaccagt ttgtagcagg agaagctgca aaactcttgg gacgtccatt agaagacttg   600
aagttaatta cctgtcatat tggtaacgga ggctcaatta cagctgtgaa agccggcaaa   660
tctgtagaca cttctatggg gttcactcct cttggtggta ttatgatggg aacgcgtaca   720
ggggatattg atccagctat cattccttat ttaatgcaat atacagagga ttttaacaca   780
ccagaagata tcagtcgtgt tcttaaccgt gaatcaggtc ttttgggagt ttctgctaat   840
tctagcgata tgcgcgatat agaagcagct gtagcagaag ggaatcacga ggctagcttg   900
gcttatgaaa tgtatgttga ccgtatccaa aaacatatcg gtcagtacct tgcagtgcta   960
aatggagcag atgccattgt tttcacagca ggtgtcggtg aaaatgcaga gagtttccgt   1020
cgtgatgtaa tctcagggat ttcgtggttt ggttgtgatg ttgatgatga aaagaatgtc   1080
tttggcgtta caggagacat ctcaacagag gcagctaaaa tccgtgtctt ggttattcca   1140
acagatgaag aattagtcat tgcccgtgac gttgaacgct tgaaaaaa                1188

<210>   4258
<211>   396
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetate kinase (ackA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903896 (0.E+01)

<400>   4258
Met Thr Lys Thr Ile Ala Ile Asn Ala Gly Ser Ser Ser Leu Lys Trp 
1               5                   10                  15      

Gln Leu Tyr Leu Met Pro Glu Glu Lys Val Leu Ala Lys Gly Leu Ile 
            20                  25                  30          

Glu Arg Ile Gly Leu Lys Asp Ser Ile Ser Thr Val Lys Phe Asp Gly 
        35                  40                  45              

Arg Ser Glu Gln Gln Ile Leu Asp Ile Glu Asn His Ile Gln Ala Val 
    50                  55                  60                  

Lys Ile Leu Leu Asp Asp Leu Ile Arg Phe Asp Ile Ile Lys Ala Tyr 
65                  70                  75                  80  

Asp Glu Ile Thr Gly Val Gly His Arg Val Val Ala Gly Gly Glu Tyr 
                85                  90                  95      

Phe Lys Glu Ser Thr Val Val Glu Gly Asp Val Leu Glu Lys Val Glu 
            100                 105                 110         

Glu Leu Ser Leu Leu Ala Pro Leu His Asn Pro Ala Asn Ala Ala Gly 
        115                 120                 125             

Val Arg Ala Phe Lys Glu Leu Leu Pro Asp Ile Thr Ser Val Val Val 
    130                 135                 140                 

Phe Asp Thr Ser Phe His Thr Ser Met Pro Glu Lys Ala Tyr Arg Tyr 
145                 150                 155                 160 

Pro Leu Pro Thr Lys Tyr Tyr Thr Glu Asn Lys Val Arg Lys Tyr Gly 
                165                 170                 175     

Ala His Gly Thr Ser His Gln Phe Val Ala Gly Glu Ala Ala Lys Leu 
            180                 185                 190         

Leu Gly Arg Pro Leu Glu Asp Leu Lys Leu Ile Thr Cys His Ile Gly 
        195                 200                 205             

Asn Gly Gly Ser Ile Thr Ala Val Lys Ala Gly Lys Ser Val Asp Thr 
    210                 215                 220                 

Ser Met Gly Phe Thr Pro Leu Gly Gly Ile Met Met Gly Thr Arg Thr 
225                 230                 235                 240 

Gly Asp Ile Asp Pro Ala Ile Ile Pro Tyr Leu Met Gln Tyr Thr Glu 
                245                 250                 255     

Asp Phe Asn Thr Pro Glu Asp Ile Ser Arg Val Leu Asn Arg Glu Ser 
            260                 265                 270         

Gly Leu Leu Gly Val Ser Ala Asn Ser Ser Asp Met Arg Asp Ile Glu 
        275                 280                 285             

Ala Ala Val Ala Glu Gly Asn His Glu Ala Ser Leu Ala Tyr Glu Met 
    290                 295                 300                 

Tyr Val Asp Arg Ile Gln Lys His Ile Gly Gln Tyr Leu Ala Val Leu 
305                 310                 315                 320 

Asn Gly Ala Asp Ala Ile Val Phe Thr Ala Gly Val Gly Glu Asn Ala 
                325                 330                 335     

Glu Ser Phe Arg Arg Asp Val Ile Ser Gly Ile Ser Trp Phe Gly Cys 
            340                 345                 350         

Asp Val Asp Asp Glu Lys Asn Val Phe Gly Val Thr Gly Asp Ile Ser 
        355                 360                 365             

Thr Glu Ala Ala Lys Ile Arg Val Leu Val Ile Pro Thr Asp Glu Glu 
    370                 375                 380                 

Leu Val Ile Ala Arg Asp Val Glu Arg Leu Lys Lys 
385                 390                 395     

<210>   4259
<211>   951
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4259
atggattttg aaaaaattga acaagcttat acctatttac tagagaatgt ccaagtcatc   60
caaagtgatt tggcgaccaa cttttatgac gccttggtgg agcaaaatag catctatctg   120
gatggtgaaa ctgagctaaa ccaggtcaag gagaacaatc aaacccttaa gcgtttagca   180
ctacgcaaag aagaatggct caagacctac cagtttctct tgatgaaggc tgggcaaaca   240
gaacccttgc aggccaatca ccagtttaca ccggatgcta ttgctttgct tttggtgttt   300
attgtggaag agttgtttaa agaggaggaa attactatcc tcgaaatggg ttctgggatg   360
ggaattctag gcgctatttt cttgacctcg cttactaaaa aggtggatta cttgggaatg   420
gaagtggatg atttgctgat tgatctggca gctagcatgg cagatgtaat tggtttgcag   480
gctggctttg tccaaggaga tgccgttcgc ccacaaatgc tcaaagaaag cgatgtggtc   540
atcagtgact tgcctgtcgg ctattatcct gatgatgccg ttgcgtcgcg ccatcaagtt   600
gcttctagcc aagaacatac ttacgcccat cacttgctca tggaacaagg gcttaagtac   660
ctcaagtcag acggatacgc tatttttcta gctccgagtg atttgttgac cagtcctcaa   720
agtgatttgt taaaagaatg gctgaaagaa gaggcgagtc tggttgctat gattagtctg   780
cctgaaaatc tctttgctaa tgccaaacaa tctaagacta tttttatctt acagaagaaa   840

aatgaaatag cagtagagcc ttttgtttat ccacttgcta gcttgcaaga tgcaagtgtt   900
ttaatgaaat ttaaagaaaa ttttcaaaaa tggactcaag gtactgaaat a            951

<210>   4260
<211>   317
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903897 (e-178)

<400>   4260
Met Asp Phe Glu Lys Ile Glu Gln Ala Tyr Thr Tyr Leu Leu Glu Asn 
1               5                   10                  15      

Val Gln Val Ile Gln Ser Asp Leu Ala Thr Asn Phe Tyr Asp Ala Leu 
            20                  25                  30          

Val Glu Gln Asn Ser Ile Tyr Leu Asp Gly Glu Thr Glu Leu Asn Gln 
        35                  40                  45              

Val Lys Glu Asn Asn Gln Thr Leu Lys Arg Leu Ala Leu Arg Lys Glu 
    50                  55                  60                  

Glu Trp Leu Lys Thr Tyr Gln Phe Leu Leu Met Lys Ala Gly Gln Thr 
65                  70                  75                  80  

Glu Pro Leu Gln Ala Asn His Gln Phe Thr Pro Asp Ala Ile Ala Leu 
                85                  90                  95      

Leu Leu Val Phe Ile Val Glu Glu Leu Phe Lys Glu Glu Glu Ile Thr 
            100                 105                 110         

Ile Leu Glu Met Gly Ser Gly Met Gly Ile Leu Gly Ala Ile Phe Leu 
        115                 120                 125             

Thr Ser Leu Thr Lys Lys Val Asp Tyr Leu Gly Met Glu Val Asp Asp 
    130                 135                 140                 

Leu Leu Ile Asp Leu Ala Ala Ser Met Ala Asp Val Ile Gly Leu Gln 
145                 150                 155                 160 

Ala Gly Phe Val Gln Gly Asp Ala Val Arg Pro Gln Met Leu Lys Glu 
                165                 170                 175     

Ser Asp Val Val Ile Ser Asp Leu Pro Val Gly Tyr Tyr Pro Asp Asp 
            180                 185                 190         

Ala Val Ala Ser Arg His Gln Val Ala Ser Ser Gln Glu His Thr Tyr 
        195                 200                 205             

Ala His His Leu Leu Met Glu Gln Gly Leu Lys Tyr Leu Lys Ser Asp 
    210                 215                 220                 

Gly Tyr Ala Ile Phe Leu Ala Pro Ser Asp Leu Leu Thr Ser Pro Gln 
225                 230                 235                 240 

Ser Asp Leu Leu Lys Glu Trp Leu Lys Glu Glu Ala Ser Leu Val Ala 
                245                 250                 255     

Met Ile Ser Leu Pro Glu Asn Leu Phe Ala Asn Ala Lys Gln Ser Lys 
            260                 265                 270         

Thr Ile Phe Ile Leu Gln Lys Lys Asn Glu Ile Ala Val Glu Pro Phe 
        275                 280                 285             

Val Tyr Pro Leu Ala Ser Leu Gln Asp Ala Ser Val Leu Met Lys Phe 
    290                 295                 300                 

Lys Glu Asn Phe Gln Lys Trp Thr Gln Gly Thr Glu Ile 
305                 310                 315         

<210>   4261
<211>   378
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4261
atgttggagc aagctcgttt gaaagtggag cagcaagcaa tcaagaatat ccagtttttg   60
gagcaagatt taccgaaaaa tcccttggag aaagagtttg attgccttgc tgttagtcgg   120
gttcttcatc atatgcctga tttggatgcg gctctctcac tgtttcatca acatttgaag   180
gaagatggga aactcatcat tgctgatttt accaagacag aagctaatca tcatggattt   240
gatttagctg aactggaaaa caagctaatt gagcatggtt tttcatctgt gcatagtcag   300
attctctata gtgctgaaga cctgtttcaa ggaaatcact cagaattctt tttaatagta   360
gcccaaaaat cactcgcc                                                 378

<210>   4262
<211>   126
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ubiquinone/menaquinone biosynthesis methlytransferase, putative, FRAMES

<400>   4262
Met Leu Glu Gln Ala Arg Leu Lys Val Glu Gln Gln Ala Ile Lys Asn 
1               5                   10                  15      

Ile Gln Phe Leu Glu Gln Asp Leu Pro Lys Asn Pro Leu Glu Lys Glu 
            20                  25                  30          

Phe Asp Cys Leu Ala Val Ser Arg Val Leu His His Met Pro Asp Leu 
        35                  40                  45              

Asp Ala Ala Leu Ser Leu Phe His Gln His Leu Lys Glu Asp Gly Lys 
    50                  55                  60                  

Leu Ile Ile Ala Asp Phe Thr Lys Thr Glu Ala Asn His His Gly Phe 
65                  70                  75                  80  

Asp Leu Ala Glu Leu Glu Asn Lys Leu Ile Glu His Gly Phe Ser Ser 
                85                  90                  95      

Val His Ser Gln Ile Leu Tyr Ser Ala Glu Asp Leu Phe Gln Gly Asn 
            100                 105                 110         

His Ser Glu Phe Phe Leu Ile Val Ala Gln Lys Ser Leu Ala 
        115                 120                 125     

<210>   4263
<211>   180
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4263
atgaaacatg attttaacca caaagcagaa actttcgatt cccctaaaaa tatcttcctc   60
gcaaacttgg tatgtcaagc agccgagaaa cagattgatc ttctatcaga caaagaaatt   120
ttagatttcg gtggtggcac gggtctatta gccttgcccc taacccctag ccaagcaggc   180

<210>   4264
<211>   60
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4264
Met Lys His Asp Phe Asn His Lys Ala Glu Thr Phe Asp Ser Pro Lys 
1               5                   10                  15      

Asn Ile Phe Leu Ala Asn Leu Val Cys Gln Ala Ala Glu Lys Gln Ile 
            20                  25                  30          

Asp Leu Leu Ser Asp Lys Glu Ile Leu Asp Phe Gly Gly Gly Thr Gly 
        35                  40                  45              

Leu Leu Ala Leu Pro Leu Thr Pro Ser Gln Ala Gly 
    50                  55                  60  

<210>   4265
<211>   411
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4265
gtgtggaaaa agaaaaaagt taaggcaggt gttctcctct acgcagtcac catagcagcc   60
atctttagtc ttttgttgca attttatttg aaccgacaag tcgcccacta tcaagactat   120
gctttgaata aagaaaaatt ggttgctttt gctatggcta aacgaaccaa agataaggtt   180
gagcaagaaa gtggggaaca gttttttaat ctaggtcagg taagctatca aaacaagaaa   240
actggcttag tgacgagggt tcgtacggat aagagccaat atgagtttct gtttccttca   300
gtcaaaatca aagaagagaa aagagataaa aaggaagagg tagcgaccga ttcaagcgaa   360
aaagtggaga agaaaaaatc agaagagaag cctgaaaaga aagagaattc a            411

<210>   4266
<211>   137
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903900 (5.E-74)

<400>   4266
Met Trp Lys Lys Lys Lys Val Lys Ala Gly Val Leu Leu Tyr Ala Val 
1               5                   10                  15      

Thr Ile Ala Ala Ile Phe Ser Leu Leu Leu Gln Phe Tyr Leu Asn Arg 
            20                  25                  30          

Gln Val Ala His Tyr Gln Asp Tyr Ala Leu Asn Lys Glu Lys Leu Val 
        35                  40                  45              

Ala Phe Ala Met Ala Lys Arg Thr Lys Asp Lys Val Glu Gln Glu Ser 
    50                  55                  60                  

Gly Glu Gln Phe Phe Asn Leu Gly Gln Val Ser Tyr Gln Asn Lys Lys 
65                  70                  75                  80  

Thr Gly Leu Val Thr Arg Val Arg Thr Asp Lys Ser Gln Tyr Glu Phe 
                85                  90                  95      

Leu Phe Pro Ser Val Lys Ile Lys Glu Glu Lys Arg Asp Lys Lys Glu 
            100                 105                 110         

Glu Val Ala Thr Asp Ser Ser Glu Lys Val Glu Lys Lys Lys Ser Glu 
        115                 120                 125             

Glu Lys Pro Glu Lys Lys Glu Asn Ser 
    130                 135         

<210>   4267
<211>   345
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4267
atgagtcagc tcctcatttc agaagttcgc taccagcaac aaagcgagca aaaggagtgg   60
ctcttgtttg tggaccaact tgaggtagaa ttagaccgtt cgcagttcga aaaagtagaa   120
ggcaatcgcc tatacatgaa gcaagatggc aaggacatcg ccatcggtaa gtcaaagtca   180
gatgatttcc gtaaaacgaa tgctcgtggt cgaggttatc agcctatggt ttatggactc   240
aaatctgtac ggattacaga ggacaatcaa ctggttcgct ttcatttcca gttccaaaaa   300
ggcttagaaa gggagttcat ctatcgtgtg gaaaaagaaa aaagt                   345

<210>   4268
<211>   115
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903901 (4.E-84)

<400>   4268
Met Ser Gln Leu Leu Ile Ser Glu Val Arg Tyr Gln Gln Gln Ser Glu 
1               5                   10                  15      

Gln Lys Glu Trp Leu Leu Phe Val Asp Gln Leu Glu Val Glu Leu Asp 
            20                  25                  30          

Arg Ser Gln Phe Glu Lys Val Glu Gly Asn Arg Leu Tyr Met Lys Gln 
        35                  40                  45              

Asp Gly Lys Asp Ile Ala Ile Gly Lys Ser Lys Ser Asp Asp Phe Arg 
    50                  55                  60                  

Lys Thr Asn Ala Arg Gly Arg Gly Tyr Gln Pro Met Val Tyr Gly Leu 
65                  70                  75                  80  

Lys Ser Val Arg Ile Thr Glu Asp Asn Gln Leu Val Arg Phe His Phe 
                85                  90                  95      

Gln Phe Gln Lys Gly Leu Glu Arg Glu Phe Ile Tyr Arg Val Glu Lys 
            100                 105                 110         

Glu Lys Ser 
        115 

<210>   4269
<211>   258
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4269
gtgattttac tggaagcagt agtcgctcta gctatctttg ccagcattgc gaccctcctt   60
ttgggacaaa ttcaaaaaaa taggcaagag gaagcaaaaa tcttgcaaaa ggaagaagtc   120
ttgagggtag ctaagatggc cctgcagacg gggcaaaatc aggtaagcat caacggagtt   180
gagattcagg tattttctag tgaaaaagga ttggaggtct accatggttc agaacagttg   240
ttggcaatca aagagcca                                                 258

<210>   4270
<211>   86
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside

<400>   4270
Met Ile Leu Leu Glu Ala Val Val Ala Leu Ala Ile Phe Ala Ser Ile 
1               5                   10                  15      

Ala Thr Leu Leu Leu Gly Gln Ile Gln Lys Asn Arg Gln Glu Glu Ala 
            20                  25                  30          

Lys Ile Leu Gln Lys Glu Glu Val Leu Arg Val Ala Lys Met Ala Leu 
        35                  40                  45              


Gln Thr Gly Gln Asn Gln Val Ser Ile Asn Gly Val Glu Ile Gln Val 
    50                  55                  60                  

Phe Ser Ser Glu Lys Gly Leu Glu Val Tyr His Gly Ser Glu Gln Leu 
65                  70                  75                  80  

Leu Ala Ile Lys Glu Pro 
                85      

<210>   4271
<211>   426
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4271
atggaggagc aaatcgtaaa gtcaatgatt aaggccttta ccatgctgga aagtctcttg   60
gttttgggac ttgtgagtat ccttgccttg ggcttgtccg gctctgtcca gtccactttt   120
tcagcggtag aggaacagat tttctttatg gagtttgaag aactctatcg ggaaacccaa   180
aaacgcagtg tagccagtca gcaaaagact agtctgaact tagatgggca gacgcttagc   240
aatggcagtc aaaagttgcc agtccctaaa ggaattcagg ccccatcagg ccaaagtatt   300
acatttgacc gagctggggg caattcgtcc ctggctaagg ttgaatttca gaccagtaaa   360
ggagcgattc gctatcaatt atatctagga aatggaaaaa ttaaacgcat taaggaaaca   420
aaaaat                                                              426

<210>   4272
<211>   142

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence protein CglD (cglD)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903902 (3.E-68)

<400>   4272
Met Glu Glu Gln Ile Val Lys Ser Met Ile Lys Ala Phe Thr Met Leu 
1               5                   10                  15      

Glu Ser Leu Leu Val Leu Gly Leu Val Ser Ile Leu Ala Leu Gly Leu 
            20                  25                  30          

Ser Gly Ser Val Gln Ser Thr Phe Ser Ala Val Glu Glu Gln Ile Phe 
        35                  40                  45              


Phe Met Glu Phe Glu Glu Leu Tyr Arg Glu Thr Gln Lys Arg Ser Val 
    50                  55                  60                  

Ala Ser Gln Gln Lys Thr Ser Leu Asn Leu Asp Gly Gln Thr Leu Ser 
65                  70                  75                  80  

Asn Gly Ser Gln Lys Leu Pro Val Pro Lys Gly Ile Gln Ala Pro Ser 
                85                  90                  95      

Gly Gln Ser Ile Thr Phe Asp Arg Ala Gly Gly Asn Ser Ser Leu Ala 
            100                 105                 110         

Lys Val Glu Phe Gln Thr Ser Lys Gly Ala Ile Arg Tyr Gln Leu Tyr 
        115                 120                 125             

Leu Gly Asn Gly Lys Ile Lys Arg Ile Lys Glu Thr Lys Asn 
    130                 135                 140         

<210>   4273
<211>   324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4273
atgaaaaaaa tgatgacatt cttgaaaaaa gctaaggtta aagcttttac attggtggag   60
atgttggtgg tcttgctgat tatcagcgtg cttttcttgc tctttgtacc taatctgacc   120
aagcaaaaag aagcagtcaa tgacaaagga aaagcagctg ttgttaaggt ggtggaaagc   180
caggcagaac tttatagctt agaaaagaat gaagatgcta gcctaagaaa gttacaagca   240
gatggacgca tcacggaaga acaggctaaa gcttataaag aatacaatga taaaaatgga   300
ggagcaaatc gtaaagtcaa tgat                                          324

<210>   4274
<211>   108
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence protein CglC (cglC)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903903 (6.E-55)

<400>   4274
Met Lys Lys Met Met Thr Phe Leu Lys Lys Ala Lys Val Lys Ala Phe 
1               5                   10                  15      

Thr Leu Val Glu Met Leu Val Val Leu Leu Ile Ile Ser Val Leu Phe 
            20                  25                  30          

Leu Leu Phe Val Pro Asn Leu Thr Lys Gln Lys Glu Ala Val Asn Asp 

        35                  40                  45              

Lys Gly Lys Ala Ala Val Val Lys Val Val Glu Ser Gln Ala Glu Leu 
    50                  55                  60                  

Tyr Ser Leu Glu Lys Asn Glu Asp Ala Ser Leu Arg Lys Leu Gln Ala 
65                  70                  75                  80  

Asp Gly Arg Ile Thr Glu Glu Gln Ala Lys Ala Tyr Lys Glu Tyr Asn 
                85                  90                  95      

Asp Lys Asn Gly Gly Ala Asn Arg Lys Val Asn Asp 
            100                 105             

<210>   4275
<211>   1041
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4275
atgagcaaat tgaccagctt cttaaagatg gacatatcac aagtcttcag gctgagacgg   60
aaaaaattag ctacagctaa gcaaaaaaat atcatcaccc tatttaacaa tctcttttct   120
agcggttttc atctggtgga gactatctcc tttttagata ggagtgcttt gttggacaag   180
cagtgtgtga cccagatgcg tgtgggcttg tctcagggga aatcattctc agaaatgatg   240
gaaagtttgg gatgttcaag tgctattgtc actcagttat ccctagctga agttcatggc   300
aatctccacc tgagtttggg aaagatagaa gaatatctgg acaatctggc taaggtcaag   360
aaaaaattga ttgaagtagc gacctatccc ttgattttgc tgggttttct tctcttaatt   420
atgctggggc tacggaatta cctgctccca caactggata gtagcaatat tgccacccaa   480
attatcggta atctgcccca aatttttcta ggcatggtag ggcttgtttc cgtgcttgcc   540
cttttagcac tcacttttta taaaagaagt tctaagatga gtgtcttttc tatcttagca   600
cgccttccct ttattggaat ctttgtgcag acctacttga cagcctatta tgcacgtgaa   660
tgggggaata tgatttcaca gggaatggag ttgacgcaga tttttcaaat gatgcaggaa   720
caaggttccc agctctttaa agaagtcggt caagatctgg ctcaaaccct gaaaaatggc   780
cgtgaatttt ctcagacgat aggaacctat cctttcttta ggaaggaatt gagtctcatc   840
atagagtatg gggaagttaa gtccaagctg ggtagtgagt tggaaatcta tgctgaaaaa   900
acttgggaag ccttttttac ccgagtcaac cgcaccatga atttggtgca gccactggtt   960
tttatctttg tggcactgat tatcgtttta ctttatgcgg caatgctcat gcccatgtat   1020
caaaatatgg aggtaaattt t                                             1041

<210>   4276
<211>   347
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence protein CglB (cglB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903904 (e-161)

<400>   4276
Met Ser Lys Leu Thr Ser Phe Leu Lys Met Asp Ile Ser Gln Val Phe 
1               5                   10                  15      

Arg Leu Arg Arg Lys Lys Leu Ala Thr Ala Lys Gln Lys Asn Ile Ile 
            20                  25                  30          

Thr Leu Phe Asn Asn Leu Phe Ser Ser Gly Phe His Leu Val Glu Thr 
        35                  40                  45              

Ile Ser Phe Leu Asp Arg Ser Ala Leu Leu Asp Lys Gln Cys Val Thr 
    50                  55                  60                  

Gln Met Arg Val Gly Leu Ser Gln Gly Lys Ser Phe Ser Glu Met Met 
65                  70                  75                  80  

Glu Ser Leu Gly Cys Ser Ser Ala Ile Val Thr Gln Leu Ser Leu Ala 
                85                  90                  95      

Glu Val His Gly Asn Leu His Leu Ser Leu Gly Lys Ile Glu Glu Tyr 
            100                 105                 110         

Leu Asp Asn Leu Ala Lys Val Lys Lys Lys Leu Ile Glu Val Ala Thr 
        115                 120                 125             

Tyr Pro Leu Ile Leu Leu Gly Phe Leu Leu Leu Ile Met Leu Gly Leu 
    130                 135                 140                 

Arg Asn Tyr Leu Leu Pro Gln Leu Asp Ser Ser Asn Ile Ala Thr Gln 
145                 150                 155                 160 

Ile Ile Gly Asn Leu Pro Gln Ile Phe Leu Gly Met Val Gly Leu Val 
                165                 170                 175     

Ser Val Leu Ala Leu Leu Ala Leu Thr Phe Tyr Lys Arg Ser Ser Lys 
            180                 185                 190         

Met Ser Val Phe Ser Ile Leu Ala Arg Leu Pro Phe Ile Gly Ile Phe 
        195                 200                 205             

Val Gln Thr Tyr Leu Thr Ala Tyr Tyr Ala Arg Glu Trp Gly Asn Met 
    210                 215                 220                 

Ile Ser Gln Gly Met Glu Leu Thr Gln Ile Phe Gln Met Met Gln Glu 
225                 230                 235                 240 

Gln Gly Ser Gln Leu Phe Lys Glu Val Gly Gln Asp Leu Ala Gln Thr 
                245                 250                 255     

Leu Lys Asn Gly Arg Glu Phe Ser Gln Thr Ile Gly Thr Tyr Pro Phe 
            260                 265                 270         

Phe Arg Lys Glu Leu Ser Leu Ile Ile Glu Tyr Gly Glu Val Lys Ser 
        275                 280                 285             

Lys Leu Gly Ser Glu Leu Glu Ile Tyr Ala Glu Lys Thr Trp Glu Ala 
    290                 295                 300                 

Phe Phe Thr Arg Val Asn Arg Thr Met Asn Leu Val Gln Pro Leu Val 
305                 310                 315                 320 

Phe Ile Phe Val Ala Leu Ile Ile Val Leu Leu Tyr Ala Ala Met Leu 
                325                 330                 335     

Met Pro Met Tyr Gln Asn Met Glu Val Asn Phe 
            340                 345         

<210>   4277
<211>   939
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4277
atggttcaag aaattgcaca agaaatcatt cgttcagctc ggaaaaaagg gacgcaggat   60
atctattttg tccctaagtt agacgcctat gagcttcata tgagggtagg agacgagcgc   120
tgtaaaattg gtagctatga ttttgaaaag tttgcagccg ttatcagtca ctttaagttt   180
gtggcgggta tgaatgtggg agaaaaaaga cgtagtcaac tgggttcctg tgattatgcc   240
tatgaccata agatagcgtc tctacgttta tctactgtag gcgattatcg ggggcatgag   300
agtttggtta tccgtttgtt gcacgatgag gagcaggacc tgcatttttg gtttcaggat   360
attgaagaat taggcaagca gtacaggcaa cggggactct atctttttgc tggtccggtt   420
gggagtggta agacgacctt gatgcatgaa ttgtccaagt cactctttaa aggacagcaa   480
gttatgtcca tcgaagatcc tgtcgaaatc aagcaggacg acatgcttca gttgcagttg   540
aacgaagcaa tcggcctaac ctatgaaaat ctaatcaaac tttccttgcg tcatcgacca   600
gatctcttga ttatcggaga aattcgtgac agcgagacgg cgcgtgcagt ggtcagagct   660
agtttgacag gtgcgacagt cttttcaacc attcacgcca agagtatccg aggtgtttat   720
gagcgtctgc tggagttggg tgtgagtgaa gaagaattgg cagttgttct gcaaggagtc   780
tgctaccaga gattaatcgg gggaggagga atcgttgact ttgcaagcag agattatcaa   840
gaacaccaag cagccaagtg gaatgagcaa attgaccagc ttcttaaaga tggacatatc   900
acaagtcttc aggctgagac ggaaaaaatt agctacagc                          939

<210>   4278
<211>   313
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence protein CglA FRAMESHIFT (cglA)
<223>   Cellular location: cytoplasm
<223>   Feature of note: similar to CT secretion
<223>   Similar to strain R6 sequence 15903905 (e-179)

<400>   4278
Met Val Gln Glu Ile Ala Gln Glu Ile Ile Arg Ser Ala Arg Lys Lys 
1               5                   10                  15      

Gly Thr Gln Asp Ile Tyr Phe Val Pro Lys Leu Asp Ala Tyr Glu Leu 
            20                  25                  30          

His Met Arg Val Gly Asp Glu Arg Cys Lys Ile Gly Ser Tyr Asp Phe 
        35                  40                  45              

Glu Lys Phe Ala Ala Val Ile Ser His Phe Lys Phe Val Ala Gly Met 
    50                  55                  60                  

Asn Val Gly Glu Lys Arg Arg Ser Gln Leu Gly Ser Cys Asp Tyr Ala 
65                  70                  75                  80  

Tyr Asp His Lys Ile Ala Ser Leu Arg Leu Ser Thr Val Gly Asp Tyr 
                85                  90                  95      

Arg Gly His Glu Ser Leu Val Ile Arg Leu Leu His Asp Glu Glu Gln 
            100                 105                 110         

Asp Leu His Phe Trp Phe Gln Asp Ile Glu Glu Leu Gly Lys Gln Tyr 
        115                 120                 125             

Arg Gln Arg Gly Leu Tyr Leu Phe Ala Gly Pro Val Gly Ser Gly Lys 
    130                 135                 140                 

Thr Thr Leu Met His Glu Leu Ser Lys Ser Leu Phe Lys Gly Gln Gln 
145                 150                 155                 160 

Val Met Ser Ile Glu Asp Pro Val Glu Ile Lys Gln Asp Asp Met Leu 
                165                 170                 175     

Gln Leu Gln Leu Asn Glu Ala Ile Gly Leu Thr Tyr Glu Asn Leu Ile 
            180                 185                 190         

Lys Leu Ser Leu Arg His Arg Pro Asp Leu Leu Ile Ile Gly Glu Ile 
        195                 200                 205             

Arg Asp Ser Glu Thr Ala Arg Ala Val Val Arg Ala Ser Leu Thr Gly 
    210                 215                 220                 

Ala Thr Val Phe Ser Thr Ile His Ala Lys Ser Ile Arg Gly Val Tyr 
225                 230                 235                 240 

Glu Arg Leu Leu Glu Leu Gly Val Ser Glu Glu Glu Leu Ala Val Val 
                245                 250                 255     

Leu Gln Gly Val Cys Tyr Gln Arg Leu Ile Gly Gly Gly Gly Ile Val 
            260                 265                 270         

Asp Phe Ala Ser Arg Asp Tyr Gln Glu His Gln Ala Ala Lys Trp Asn 
        275                 280                 285             

Glu Gln Ile Asp Gln Leu Leu Lys Asp Gly His Ile Thr Ser Leu Gln 
    290                 295                 300                 

Ala Glu Thr Glu Lys Ile Ser Tyr Ser 
305                 310             

<210>   4279
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4279
ttgaccagta ttatgatgct ctcaaatact acaaaacttg ctggtttaga ttggaacaag   60
aatcgcctct ttataaaagt agaagcgact                                    90

<210>   4280
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4280
Met Thr Ser Ile Met Met Leu Ser Asn Thr Thr Lys Leu Ala Gly Leu 
1               5                   10                  15      

Asp Trp Asn Lys Asn Arg Leu Phe Ile Lys Val Glu Ala Thr 
            20                  25                  30  

<210>   4281
<211>   369
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4281
atgaatatgt atcgtgttat agaaatgtac ggagattttg aaccgtggtg gttcttagaa   60
ggttgggaag aagatattgt agcaagtaga aaatttgacc agtattatga tgctctcaaa   120
tactacaaaa cttgctggtt tagattggaa caagaatcgc ctctttataa aagtagaagc   180
gacttgatga ccattttttg ggacccggaa gaccaacgct ggtgtgatga atgtgatgag   240
tatttacaac aataccattc tttggctctt ttgcaggatg agcaggttat cccagacgaa   300
aaactacgct caggctatga aaaacaaacc agtcaggaaa ggaatcgttc ttgccgtatg   360
aaattaaaa                                                           369

<210>   4282
<211>   123
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903906 (2.E-74)

<400>   4282
Met Asn Met Tyr Arg Val Ile Glu Met Tyr Gly Asp Phe Glu Pro Trp 
1               5                   10                  15      

Trp Phe Leu Glu Gly Trp Glu Glu Asp Ile Val Ala Ser Arg Lys Phe 
            20                  25                  30          

Asp Gln Tyr Tyr Asp Ala Leu Lys Tyr Tyr Lys Thr Cys Trp Phe Arg 
        35                  40                  45              

Leu Glu Gln Glu Ser Pro Leu Tyr Lys Ser Arg Ser Asp Leu Met Thr 
    50                  55                  60                  

Ile Phe Trp Asp Pro Glu Asp Gln Arg Trp Cys Asp Glu Cys Asp Glu 
65                  70                  75                  80  

Tyr Leu Gln Gln Tyr His Ser Leu Ala Leu Leu Gln Asp Glu Gln Val 
                85                  90                  95      

Ile Pro Asp Glu Lys Leu Arg Ser Gly Tyr Glu Lys Gln Thr Ser Gln 
            100                 105                 110         

Glu Arg Asn Arg Ser Cys Arg Met Lys Leu Lys 
        115                 120             

<210>   4283
<211>   1056
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4283
atgaaagcct atacttatgt taaaccagga cttgcttctt ttgttgatgt agacaaacca   60
gttattcgca agccaacaga cgctattgtg cgtattgtaa aaaccactat ttgtggaaca   120
gacctccata ttatcaaagg ggatgttcct acttgccaaa gtggtaccat tcttggccac   180
gaagggattg ggattgttga agaagttggg gaaggagttt ccaacttcaa aaaaggtgac   240
aaggtcttga tttcttgcgt ctgtgcctgt ggtaaatgct actactgtaa aaaaggaatt   300
tatgctcact gtgaagacga agggggctgg attttcggtc acttgattga tggtatgcag   360
gctgaatatc tacgtgtccc tcatgcagat aatactcttt accatactcc agaagacttg   420
tcagatgaag ctttggttat gctgtcagac attctgccta ctggatatga aattggtgtc   480
ttaaaaggga aagtagaacc tggttgcagc gtagccatta ttggttcagg tccagttgga   540
ttggctgctc ttttaacagc ccaattctat tcaccagcta aattgattat ggtagaccta   600
gacgataacc gcttggaaac tgccctatca ttcggtgcga ctcataaggt taattcttca   660
gaccctgaaa aagccattaa agaaatttat gatttgacag atggtcgtgg tgtggatgtc   720
gctatcgaag ctgttggtat tcctgcaaca tttgatttct gtcaaaagat tatcggtgta   780
gacggaacgg ttgccaactg tggtgtgcat ggtaaaccag ttgaattcga tttagataaa   840
ctttggattc gcaacatcaa tgtaacaact ggtttggtat ctacaaatac gactccacaa   900
ttgttgaaag cacttgaaag tcataagatt gaaccggaaa aattggtaac tcactatttc   960
aaactcagtg aaattgaaaa agcctacgaa gtcttcagta aggcagcaga ccaccatgcc   1020
attaaggtca ttatcgaaaa cgatatctca gaagcc                             1056

<210>   4284
<211>   352
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alcohol dehydrogenase, zinc-containing
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903907 (0.E+01)

<400>   4284
Met Lys Ala Tyr Thr Tyr Val Lys Pro Gly Leu Ala Ser Phe Val Asp 
1               5                   10                  15      

Val Asp Lys Pro Val Ile Arg Lys Pro Thr Asp Ala Ile Val Arg Ile 
            20                  25                  30          

Val Lys Thr Thr Ile Cys Gly Thr Asp Leu His Ile Ile Lys Gly Asp 
        35                  40                  45              

Val Pro Thr Cys Gln Ser Gly Thr Ile Leu Gly His Glu Gly Ile Gly 
    50                  55                  60                  

Ile Val Glu Glu Val Gly Glu Gly Val Ser Asn Phe Lys Lys Gly Asp 
65                  70                  75                  80  

Lys Val Leu Ile Ser Cys Val Cys Ala Cys Gly Lys Cys Tyr Tyr Cys 
                85                  90                  95      

Lys Lys Gly Ile Tyr Ala His Cys Glu Asp Glu Gly Gly Trp Ile Phe 
            100                 105                 110         

Gly His Leu Ile Asp Gly Met Gln Ala Glu Tyr Leu Arg Val Pro His 
        115                 120                 125             

Ala Asp Asn Thr Leu Tyr His Thr Pro Glu Asp Leu Ser Asp Glu Ala 
    130                 135                 140                 

Leu Val Met Leu Ser Asp Ile Leu Pro Thr Gly Tyr Glu Ile Gly Val 
145                 150                 155                 160 

Leu Lys Gly Lys Val Glu Pro Gly Cys Ser Val Ala Ile Ile Gly Ser 
                165                 170                 175     

Gly Pro Val Gly Leu Ala Ala Leu Leu Thr Ala Gln Phe Tyr Ser Pro 
            180                 185                 190         

Ala Lys Leu Ile Met Val Asp Leu Asp Asp Asn Arg Leu Glu Thr Ala 
        195                 200                 205             

Leu Ser Phe Gly Ala Thr His Lys Val Asn Ser Ser Asp Pro Glu Lys 
    210                 215                 220                 

Ala Ile Lys Glu Ile Tyr Asp Leu Thr Asp Gly Arg Gly Val Asp Val 
225                 230                 235                 240 

Ala Ile Glu Ala Val Gly Ile Pro Ala Thr Phe Asp Phe Cys Gln Lys 
                245                 250                 255     

Ile Ile Gly Val Asp Gly Thr Val Ala Asn Cys Gly Val His Gly Lys 
            260                 265                 270         

Pro Val Glu Phe Asp Leu Asp Lys Leu Trp Ile Arg Asn Ile Asn Val 
        275                 280                 285             

Thr Thr Gly Leu Val Ser Thr Asn Thr Thr Pro Gln Leu Leu Lys Ala 
    290                 295                 300                 

Leu Glu Ser His Lys Ile Glu Pro Glu Lys Leu Val Thr His Tyr Phe 
305                 310                 315                 320 

Lys Leu Ser Glu Ile Glu Lys Ala Tyr Glu Val Phe Ser Lys Ala Ala 
                325                 330                 335     

Asp His His Ala Ile Lys Val Ile Ile Glu Asn Asp Ile Ser Glu Ala 
            340                 345                 350         


<210>   4285
<211>   1149
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4285
atgcctaact atattaaagc ggatcagttt ttctacccac acggagttcg tcgaggtggt   60
tacttggaac ttgtggacgg caagtttggg aaacatgtag agcagattcc tgaaggggct   120
gaggtgattg actatacagg ttatagcatt gccccaggtc ttgtggatac tcatattcat   180
ggatatgcag gtgtagatgt gatggacaac aacattgaag gtacattgca tactatgagt   240
gaaggacttc ttagtaccgg tgttaccagt ttcttaccca caactttaac agccacttat   300
gagcaattgc ttgcagtcac tgaaaatctt ggaaaccatt ataaagaagc aacaggtgct   360
aagattcgtg ggatttatta tgaaggtcca tatttcacag aaacttttaa gggggcacaa   420
aatccaactt atatgagaga cccgggtgtt gaggagtttc attcttggca aaaagcggca   480
aatggcttgc ttaataaaat tgcccttgca ccagaacgtg atggggtgga agactttgtt   540
cgtacagtta cgggcgaagg tgtgacggtt gctcttggac attcaaacgc gacttttgat   600
gaagccaaaa aagcaatcga tgctggagcg agtgtttggg tgcatgccta caatggaatg   660
cgtgggttga ctcaccgtga attggggatg gttggagcca tgtaccaatt gccacatacc   720
tatgcagagt tgatctgtga tggtcaccac gtagatccaa aggcttgcga aattcttatc   780
aaacaaaaag gaacagaaaa catcgctctt atcacagact gtatgacagc tgggggattg   840
gaagacggag attatatgtt gggagaattc ccagttgtcg ttgcaaatgg aactgcacgc   900
ctcaaatcga caggtaactt ggcaggttct atcctcaaac tcaaagatgg tttgaagaat   960
gtggtcgaat ggggaattgc gaatccgcat gaagcagtca tgatggccag cttcaaccca   1020
gctaaatccg ttcacatcga tgacgtctgt ggccaaatcc gtgaaggcta cgacgctgac   1080
ttcatcgtat tagataaaga tttggaattg gtagcaacct acctagatgg cgtaaaacgt   1140
tatcaagca                                                           1149

<210>   4286
<211>   383
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   N-acetylglucosamine-6-phosphate deacetylase (nagA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903908 (0.E+01)

<400>   4286
Met Pro Asn Tyr Ile Lys Ala Asp Gln Phe Phe Tyr Pro His Gly Val 
1               5                   10                  15      

Arg Arg Gly Gly Tyr Leu Glu Leu Val Asp Gly Lys Phe Gly Lys His 
            20                  25                  30          

Val Glu Gln Ile Pro Glu Gly Ala Glu Val Ile Asp Tyr Thr Gly Tyr 
        35                  40                  45              

Ser Ile Ala Pro Gly Leu Val Asp Thr His Ile His Gly Tyr Ala Gly 
    50                  55                  60                  

Val Asp Val Met Asp Asn Asn Ile Glu Gly Thr Leu His Thr Met Ser 
65                  70                  75                  80  

Glu Gly Leu Leu Ser Thr Gly Val Thr Ser Phe Leu Pro Thr Thr Leu 
                85                  90                  95      

Thr Ala Thr Tyr Glu Gln Leu Leu Ala Val Thr Glu Asn Leu Gly Asn 
            100                 105                 110         

His Tyr Lys Glu Ala Thr Gly Ala Lys Ile Arg Gly Ile Tyr Tyr Glu 
        115                 120                 125             

Gly Pro Tyr Phe Thr Glu Thr Phe Lys Gly Ala Gln Asn Pro Thr Tyr 
    130                 135                 140                 

Met Arg Asp Pro Gly Val Glu Glu Phe His Ser Trp Gln Lys Ala Ala 
145                 150                 155                 160 

Asn Gly Leu Leu Asn Lys Ile Ala Leu Ala Pro Glu Arg Asp Gly Val 
                165                 170                 175     

Glu Asp Phe Val Arg Thr Val Thr Gly Glu Gly Val Thr Val Ala Leu 
            180                 185                 190         

Gly His Ser Asn Ala Thr Phe Asp Glu Ala Lys Lys Ala Ile Asp Ala 
        195                 200                 205             

Gly Ala Ser Val Trp Val His Ala Tyr Asn Gly Met Arg Gly Leu Thr 
    210                 215                 220                 

His Arg Glu Leu Gly Met Val Gly Ala Met Tyr Gln Leu Pro His Thr 
225                 230                 235                 240 

Tyr Ala Glu Leu Ile Cys Asp Gly His His Val Asp Pro Lys Ala Cys 
                245                 250                 255     

Glu Ile Leu Ile Lys Gln Lys Gly Thr Glu Asn Ile Ala Leu Ile Thr 
            260                 265                 270         

Asp Cys Met Thr Ala Gly Gly Leu Glu Asp Gly Asp Tyr Met Leu Gly 
        275                 280                 285             

Glu Phe Pro Val Val Val Ala Asn Gly Thr Ala Arg Leu Lys Ser Thr 
    290                 295                 300                 

Gly Asn Leu Ala Gly Ser Ile Leu Lys Leu Lys Asp Gly Leu Lys Asn 
305                 310                 315                 320 

Val Val Glu Trp Gly Ile Ala Asn Pro His Glu Ala Val Met Met Ala 
                325                 330                 335     


Ser Phe Asn Pro Ala Lys Ser Val His Ile Asp Asp Val Cys Gly Gln 
            340                 345                 350         

Ile Arg Glu Gly Tyr Asp Ala Asp Phe Ile Val Leu Asp Lys Asp Leu 
        355                 360                 365             

Glu Leu Val Ala Thr Tyr Leu Asp Gly Val Lys Arg Tyr Gln Ala 
    370                 375                 380             

<210>   4287
<211>   1815
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4287
atgcgcatta aatggttttc cttgattagg attataggtt tacttttggt actcttgtat   60
cacttctttc agacgatctt tcctggagga tttttcgggg tagatgtctt tttcacattt   120
tcaggtttcc tgattacagc tctactcatt gaagaatttt ctaagaacaa tgagattgat   180
ttgataggat tttttagaag acgcttttat cggattgtgc cacctgtggt tttgatggtc   240
ttggtgacca tgccttttac tttcttggtt cgccaagact atgttgctgg aattggtggc   300
cagattgcgg gcgtcttagg ctttatgacc aacttctatg aactcctaac aggtgggagt   360
tatgaatctc agttcattcc tcatttgttt gttcataatt ggagtttggc agttgaggtt   420
cactactata ttctttgggg attggcagtt tggttcttat ccaaacaagc taaatcaaat   480
ggtcagttga aggggatggt ctttctctta tctgctgttg ccttcttgat cagtttcttc   540
tccatgttta ttggtagttt tctagtgacc tcttattcct ctgtttattt ctccagttta   600
actcatgtct atccattctt tttaggaagt atgttagcaa ctattgtagg cgttcgtcag   660
acgacttccc tcgtcaagca gttggataaa atctgggatt tacgaaagac tttggtagtt   720
tttggaggag gctttggttt cctagttctt ttgactttct ttgtcaaatt cacttatctt   780
tttgcctatc ttatcggctt cttacttgcc agtcttgcag ctcttgccat gattctggcg   840
gcgcgtgtct tacatgaaaa gacacatcat atacaggagt cgaagattat cagcttttta   900
gcggatacta gctatgcggt ttatcttttc cattggcctt tctatatcat tttctcacag   960
ttgacatcaa atcttcttgc tgtattactg actctgattt gttcttatgg ctttgccagt   1020
ctgtcatttt atgtattgga accttggatt gcaggcaaga acacacctat tgtccaaacc   1080
cttcgtcccc tgccttatat tcacgcaatt cttgcagcag gtacaggaat cttgaccatc   1140
attgtctgca cggtgacctt gttggcacca caagtgggag cgtttgagac agacttgact   1200
gtcaatggct tgaagcaagc tgcaacaaat attggccaga ccaaggtgat ggcagaacgg   1260
gcagatgcaa acagtttggg aattgctgat ggcactatgt taattggtga ctcagtggct   1320
ttaagggcaa atacagcact acagacagct cttcctggag cacagattaa cgcgcaggtc   1380
agcgtaacaa ccaagaccgc aaatgaaatc atgctaaata atagccagaa taaattttta   1440
cctaagacgg tggtcattgc gactggggta aataatcctg agaattacaa ggatgactgg   1500
gacagtatcg tgaaaaatct tcctaaggga caccatatga ttttggtgac tccttatgag   1560
ggagataaga caaaagagac ctatgccatc gttgagaagg ctgctgccta tatgagagaa   1620
ttggcagaga agacacctta cattacgata gcagattgga atcaagttgc gaaagagcat   1680
ccagaaattt gggctggaac agaccaggtt catttcggga gtgagagtag cactatcgaa   1740
gcaggagcaa aattgtatgc agatacgatt gccacagctt tgcagacagc tcaagacaag   1800
ccggttaaat caaaa                                                    1815

<210>   4288
<211>   605
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903909 (0.E+01)

<400>   4288
Met Arg Ile Lys Trp Phe Ser Leu Ile Arg Ile Ile Gly Leu Leu Leu 
1               5                   10                  15      

Val Leu Leu Tyr His Phe Phe Gln Thr Ile Phe Pro Gly Gly Phe Phe 
            20                  25                  30          

Gly Val Asp Val Phe Phe Thr Phe Ser Gly Phe Leu Ile Thr Ala Leu 
        35                  40                  45              

Leu Ile Glu Glu Phe Ser Lys Asn Asn Glu Ile Asp Leu Ile Gly Phe 
    50                  55                  60                  

Phe Arg Arg Arg Phe Tyr Arg Ile Val Pro Pro Val Val Leu Met Val 
65                  70                  75                  80  

Leu Val Thr Met Pro Phe Thr Phe Leu Val Arg Gln Asp Tyr Val Ala 
                85                  90                  95      

Gly Ile Gly Gly Gln Ile Ala Gly Val Leu Gly Phe Met Thr Asn Phe 
            100                 105                 110         

Tyr Glu Leu Leu Thr Gly Gly Ser Tyr Glu Ser Gln Phe Ile Pro His 
        115                 120                 125             

Leu Phe Val His Asn Trp Ser Leu Ala Val Glu Val His Tyr Tyr Ile 
    130                 135                 140                 

Leu Trp Gly Leu Ala Val Trp Phe Leu Ser Lys Gln Ala Lys Ser Asn 
145                 150                 155                 160 

Gly Gln Leu Lys Gly Met Val Phe Leu Leu Ser Ala Val Ala Phe Leu 
                165                 170                 175     

Ile Ser Phe Phe Ser Met Phe Ile Gly Ser Phe Leu Val Thr Ser Tyr 
            180                 185                 190         

Ser Ser Val Tyr Phe Ser Ser Leu Thr His Val Tyr Pro Phe Phe Leu 
        195                 200                 205             

Gly Ser Met Leu Ala Thr Ile Val Gly Val Arg Gln Thr Thr Ser Leu 
    210                 215                 220                 

Val Lys Gln Leu Asp Lys Ile Trp Asp Leu Arg Lys Thr Leu Val Val 
225                 230                 235                 240 

Phe Gly Gly Gly Phe Gly Phe Leu Val Leu Leu Thr Phe Phe Val Lys 
                245                 250                 255     

Phe Thr Tyr Leu Phe Ala Tyr Leu Ile Gly Phe Leu Leu Ala Ser Leu 
            260                 265                 270         

Ala Ala Leu Ala Met Ile Leu Ala Ala Arg Val Leu His Glu Lys Thr 
        275                 280                 285             

His His Ile Gln Glu Ser Lys Ile Ile Ser Phe Leu Ala Asp Thr Ser 
    290                 295                 300                 

Tyr Ala Val Tyr Leu Phe His Trp Pro Phe Tyr Ile Ile Phe Ser Gln 
305                 310                 315                 320 

Leu Thr Ser Asn Leu Leu Ala Val Leu Leu Thr Leu Ile Cys Ser Tyr 
                325                 330                 335     

Gly Phe Ala Ser Leu Ser Phe Tyr Val Leu Glu Pro Trp Ile Ala Gly 
            340                 345                 350         

Lys Asn Thr Pro Ile Val Gln Thr Leu Arg Pro Leu Pro Tyr Ile His 
        355                 360                 365             

Ala Ile Leu Ala Ala Gly Thr Gly Ile Leu Thr Ile Ile Val Cys Thr 
    370                 375                 380                 

Val Thr Leu Leu Ala Pro Gln Val Gly Ala Phe Glu Thr Asp Leu Thr 
385                 390                 395                 400 

Val Asn Gly Leu Lys Gln Ala Ala Thr Asn Ile Gly Gln Thr Lys Val 
                405                 410                 415     

Met Ala Glu Arg Ala Asp Ala Asn Ser Leu Gly Ile Ala Asp Gly Thr 
            420                 425                 430         

Met Leu Ile Gly Asp Ser Val Ala Leu Arg Ala Asn Thr Ala Leu Gln 
        435                 440                 445             

Thr Ala Leu Pro Gly Ala Gln Ile Asn Ala Gln Val Ser Val Thr Thr 
    450                 455                 460                 

Lys Thr Ala Asn Glu Ile Met Leu Asn Asn Ser Gln Asn Lys Phe Leu 
465                 470                 475                 480 

Pro Lys Thr Val Val Ile Ala Thr Gly Val Asn Asn Pro Glu Asn Tyr 
                485                 490                 495     

Lys Asp Asp Trp Asp Ser Ile Val Lys Asn Leu Pro Lys Gly His His 
            500                 505                 510         

Met Ile Leu Val Thr Pro Tyr Glu Gly Asp Lys Thr Lys Glu Thr Tyr 
        515                 520                 525             

Ala Ile Val Glu Lys Ala Ala Ala Tyr Met Arg Glu Leu Ala Glu Lys 
    530                 535                 540                 

Thr Pro Tyr Ile Thr Ile Ala Asp Trp Asn Gln Val Ala Lys Glu His 
545                 550                 555                 560 

Pro Glu Ile Trp Ala Gly Thr Asp Gln Val His Phe Gly Ser Glu Ser 
                565                 570                 575     

Ser Thr Ile Glu Ala Gly Ala Lys Leu Tyr Ala Asp Thr Ile Ala Thr 
            580                 585                 590         

Ala Leu Gln Thr Ala Gln Asp Lys Pro Val Lys Ser Lys 
        595                 600                 605 

<210>   4289
<211>   1140
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4289
atgtcagatt caccaatcaa atatcgtttg attaagaaag aaaaacacac aggagctcgt   60
ctgggagaaa tcatcactcc ccacggtacc tttccgacac ctatgtttat gccagttggg   120
acacaagcca ctgtcaaaac tcagtcacct gaagaattga aggagatggg ttcgggaatt   180
atcctatcaa acacctatca tctctggctt cgccctggag atgaactcat tgcacgcgct   240
ggtggtctcc acaagttcat gaattgggac cagcctatct tgacagatag tggtggtttt   300
caggtttatt ctttagcaga tagccgtaat atcacagaag aaggagtaac ctttaaaaat   360
catctaaatg gttctaagat gttcctatcc ccagaaaaag ccatctctat tcagaataat   420
ctgggttcag acatcatgat gtcctttgat gaatgtcctc agttttatca accttatgac   480
tacgttaaga aatcgatcga gcgtaccagc cgttgggctg agcgtggttt gaaggctcac   540
cgtcgtccac atgaccaagg tttgtttgga attgtgcaag gtgcaggatt tgaagacctt   600
cgccgccaat cagctcatga tcttgtcagc atggatttct caggctactc tatcggtggt   660
ttggcagtgg gagaaaccca tgaagagatg aatgcggtct tggactttac aactcaactg   720
ctgcctgaaa ataaacctcg ttatctgatg ggtgtgggag cgccagatag cttgatcgat   780
ggggtcattc gtggggtgga tatgtttgac tgtgtcttac cgactcgaat tgctcgtaac   840
gggacttgta tgaccagtca aggacgtttg gttgtgaaaa atgcccagtt tgctgaggac   900
tttacgccac tggatcctga gtgtgattgc tacacatgta ataactatac acgcgcttac   960
cttcgtcacc tgctcaaggc tgatgaaacc tttggtatcc gcttgactag ctaccacaat   1020
ctttacttct tgcttaacct gatgaagcaa gtgcgacaag ccatcatgga tgacaatctc   1080
ttggaattcc gtgagtattt tgtggaaaaa tatggctata ataagtcagg acgtaatttc   1140

<210>   4290
<211>   380
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tRNA-guanine transglycosylase (tgt)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903910 (0.E+01)

<400>   4290
Met Ser Asp Ser Pro Ile Lys Tyr Arg Leu Ile Lys Lys Glu Lys His 
1               5                   10                  15      

Thr Gly Ala Arg Leu Gly Glu Ile Ile Thr Pro His Gly Thr Phe Pro 
            20                  25                  30          

Thr Pro Met Phe Met Pro Val Gly Thr Gln Ala Thr Val Lys Thr Gln 
        35                  40                  45              

Ser Pro Glu Glu Leu Lys Glu Met Gly Ser Gly Ile Ile Leu Ser Asn 
    50                  55                  60                  

Thr Tyr His Leu Trp Leu Arg Pro Gly Asp Glu Leu Ile Ala Arg Ala 
65                  70                  75                  80  

Gly Gly Leu His Lys Phe Met Asn Trp Asp Gln Pro Ile Leu Thr Asp 
                85                  90                  95      

Ser Gly Gly Phe Gln Val Tyr Ser Leu Ala Asp Ser Arg Asn Ile Thr 
            100                 105                 110         

Glu Glu Gly Val Thr Phe Lys Asn His Leu Asn Gly Ser Lys Met Phe 
        115                 120                 125             

Leu Ser Pro Glu Lys Ala Ile Ser Ile Gln Asn Asn Leu Gly Ser Asp 
    130                 135                 140                 

Ile Met Met Ser Phe Asp Glu Cys Pro Gln Phe Tyr Gln Pro Tyr Asp 
145                 150                 155                 160 

Tyr Val Lys Lys Ser Ile Glu Arg Thr Ser Arg Trp Ala Glu Arg Gly 
                165                 170                 175     

Leu Lys Ala His Arg Arg Pro His Asp Gln Gly Leu Phe Gly Ile Val 
            180                 185                 190         

Gln Gly Ala Gly Phe Glu Asp Leu Arg Arg Gln Ser Ala His Asp Leu 
        195                 200                 205             

Val Ser Met Asp Phe Ser Gly Tyr Ser Ile Gly Gly Leu Ala Val Gly 
    210                 215                 220                 

Glu Thr His Glu Glu Met Asn Ala Val Leu Asp Phe Thr Thr Gln Leu 
225                 230                 235                 240 

Leu Pro Glu Asn Lys Pro Arg Tyr Leu Met Gly Val Gly Ala Pro Asp 
                245                 250                 255     

Ser Leu Ile Asp Gly Val Ile Arg Gly Val Asp Met Phe Asp Cys Val 
            260                 265                 270         

Leu Pro Thr Arg Ile Ala Arg Asn Gly Thr Cys Met Thr Ser Gln Gly 
        275                 280                 285             

Arg Leu Val Val Lys Asn Ala Gln Phe Ala Glu Asp Phe Thr Pro Leu 
    290                 295                 300                 

Asp Pro Glu Cys Asp Cys Tyr Thr Cys Asn Asn Tyr Thr Arg Ala Tyr 
305                 310                 315                 320 

Leu Arg His Leu Leu Lys Ala Asp Glu Thr Phe Gly Ile Arg Leu Thr 
                325                 330                 335     

Ser Tyr His Asn Leu Tyr Phe Leu Leu Asn Leu Met Lys Gln Val Arg 
            340                 345                 350         

Gln Ala Ile Met Asp Asp Asn Leu Leu Glu Phe Arg Glu Tyr Phe Val 
        355                 360                 365             

Glu Lys Tyr Gly Tyr Asn Lys Ser Gly Arg Asn Phe 
    370                 375                 380 

<210>   4291
<211>   855
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4291
atgaactatc caaaaattga tttaaaaaca attcgtcagg agtcaaaaca ttttcaggct   60
gacacccccc gtctctttct cctctatatc cttcccagta tgctggtcat cttatctggt   120
tttcttaatc ccttatctcg gatccacggg actgttttag aacagccatt tttcagcata   180
cttggccaaa tacttcaaac ctacctcttt cctctactag tctcctttat cgggactatt   240
cttttgacca gttccgtcta tgcaacactg acactcatga aagattctaa aacggagcca   300
tctgtaaaaa acagcctagc tctctttgat gaggagcgct tttctcaaac ctttttgacc   360
ctacttctca aacgtttcta tctcttttta tggagtatcc ctaatttact tgggatttac   420
ctcctctttt atagtagctt tttagccaaa aaattcgtca ccctacatcc tgagtttcca   480
aatctagatc tctcatcagt tgaaaccgag cgtttcctca tggtctttgg actctacttt   540
cttgcaagtc tcatcttgat cattgtagga aatatcctct atattccaca gtattatgcc   600
tattcacagg tggaatttct tctctgttat agtctagacc taggacaggt cccaccaaga   660
cgaatcctaa aaactagccg ttcctttatg aagggctaca agttccagca ctttgtccta   720
gatttacagc ttcttccttg gtacttcctc aattggatta cctttggcat tgctagtttt   780
tcactcctac cttatatcca atgcactaaa attatgtttt accgagcagt attggcccga   840
aaacgtccaa aagct                                                    855

<210>   4292
<211>   285
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903911 (e-161)

<400>   4292
Met Asn Tyr Pro Lys Ile Asp Leu Lys Thr Ile Arg Gln Glu Ser Lys 
1               5                   10                  15      

His Phe Gln Ala Asp Thr Pro Arg Leu Phe Leu Leu Tyr Ile Leu Pro 
            20                  25                  30          

Ser Met Leu Val Ile Leu Ser Gly Phe Leu Asn Pro Leu Ser Arg Ile 
        35                  40                  45              

His Gly Thr Val Leu Glu Gln Pro Phe Phe Ser Ile Leu Gly Gln Ile 
    50                  55                  60                  

Leu Gln Thr Tyr Leu Phe Pro Leu Leu Val Ser Phe Ile Gly Thr Ile 
65                  70                  75                  80  

Leu Leu Thr Ser Ser Val Tyr Ala Thr Leu Thr Leu Met Lys Asp Ser 
                85                  90                  95      

Lys Thr Glu Pro Ser Val Lys Asn Ser Leu Ala Leu Phe Asp Glu Glu 
            100                 105                 110         

Arg Phe Ser Gln Thr Phe Leu Thr Leu Leu Leu Lys Arg Phe Tyr Leu 
        115                 120                 125             

Phe Leu Trp Ser Ile Pro Asn Leu Leu Gly Ile Tyr Leu Leu Phe Tyr 
    130                 135                 140                 

Ser Ser Phe Leu Ala Lys Lys Phe Val Thr Leu His Pro Glu Phe Pro 
145                 150                 155                 160 

Asn Leu Asp Leu Ser Ser Val Glu Thr Glu Arg Phe Leu Met Val Phe 
                165                 170                 175     

Gly Leu Tyr Phe Leu Ala Ser Leu Ile Leu Ile Ile Val Gly Asn Ile 
            180                 185                 190         

Leu Tyr Ile Pro Gln Tyr Tyr Ala Tyr Ser Gln Val Glu Phe Leu Leu 
        195                 200                 205             

Cys Tyr Ser Leu Asp Leu Gly Gln Val Pro Pro Arg Arg Ile Leu Lys 
    210                 215                 220                 

Thr Ser Arg Ser Phe Met Lys Gly Tyr Lys Phe Gln His Phe Val Leu 
225                 230                 235                 240 

Asp Leu Gln Leu Leu Pro Trp Tyr Phe Leu Asn Trp Ile Thr Phe Gly 
                245                 250                 255     

Ile Ala Ser Phe Ser Leu Leu Pro Tyr Ile Gln Cys Thr Lys Ile Met 
            260                 265                 270         


Phe Tyr Arg Ala Val Leu Ala Arg Lys Arg Pro Lys Ala 
        275                 280                 285 

<210>   4293
<211>   642
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4293
atgaaagtat tagtgacagg ttttgagccc tttggagggg aaaagggcaa tccagctttg   60
gaggccatta aaggtttacc agctgaaatc catggtgctg aggtccgttg gctagaggtg   120
ccgacagttt ttcacaaatc tgctcaagta ttggaagaag agatgaatcg ttatcaacct   180
gactttgtcc tttgtattgg gcaagctggt ggaagaacta gtttgacacc tgaacgagtg   240
accattaatc aagacgatgc atgcatttct gataacgaag ataatcaacc gattgaccgt   300
cccattcgcc cagatggtgc ttcggcctac tttagtagtt tgccgattaa agcgatggtt   360
caagctataa aaaaagaggg cttaccggcc tctgtttcca atacggcagg gacttttgtc   420
tgcagccatt tgatgtatca ggctctctat ttggtagaaa agaaatctcc atatgttaag   480
gcaggtttta tgcatattcc ttatatgatg gaacaggtgg tgaacagacc gactactcca   540
gctatgagtt tagtggatat tcggcgaggg atagaagcag caatcggcgc tataatagaa   600
catggagatc aggaactcaa gttggtaggc ggagaaactc at                      642

<210>   4294
<211>   214
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   pyrrolidone-carboxylate peptidase (pcp)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902806 (6.E-95)

<400>   4294
Met Lys Val Leu Val Thr Gly Phe Glu Pro Phe Gly Gly Glu Lys Gly 
1               5                   10                  15      

Asn Pro Ala Leu Glu Ala Ile Lys Gly Leu Pro Ala Glu Ile His Gly 
            20                  25                  30          

Ala Glu Val Arg Trp Leu Glu Val Pro Thr Val Phe His Lys Ser Ala 
        35                  40                  45              

Gln Val Leu Glu Glu Glu Met Asn Arg Tyr Gln Pro Asp Phe Val Leu 
    50                  55                  60                  

Cys Ile Gly Gln Ala Gly Gly Arg Thr Ser Leu Thr Pro Glu Arg Val 
65                  70                  75                  80  

Thr Ile Asn Gln Asp Asp Ala Cys Ile Ser Asp Asn Glu Asp Asn Gln 
                85                  90                  95      

Pro Ile Asp Arg Pro Ile Arg Pro Asp Gly Ala Ser Ala Tyr Phe Ser 
            100                 105                 110         

Ser Leu Pro Ile Lys Ala Met Val Gln Ala Ile Lys Lys Glu Gly Leu 
        115                 120                 125             

Pro Ala Ser Val Ser Asn Thr Ala Gly Thr Phe Val Cys Ser His Leu 
    130                 135                 140                 

Met Tyr Gln Ala Leu Tyr Leu Val Glu Lys Lys Ser Pro Tyr Val Lys 
145                 150                 155                 160 

Ala Gly Phe Met His Ile Pro Tyr Met Met Glu Gln Val Val Asn Arg 

                165                 170                 175     

Pro Thr Thr Pro Ala Met Ser Leu Val Asp Ile Arg Arg Gly Ile Glu 
            180                 185                 190         

Ala Ala Ile Gly Ala Ile Ile Glu His Gly Asp Gln Glu Leu Lys Leu 
        195                 200                 205             

Val Gly Gly Glu Thr His 
    210                 

<210>   4295
<211>   357
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4295
atgtcaatta ttttaacaac gatcgttgct ttggagcatt tttacatttt ttatttggaa   60
agtattgcca cgcaatcaga tgcgactagt cgtgtattta atatggaaaa ggaagaattg   120
gctcatccgt cagtaagttc attgttcaaa aatcaaggaa tttataaggc tctgctagga   180
gtctttctct tgtatgtcat ttatttctca cagaatttag aaattgtgac tatttttgtc   240
ttatttgtga ttggtgctgc gacttacggc tctttaacag cggataaaaa aattattttg   300
aaacaaggtg gatcagctat tttggccttg attagtattt tactctttaa atacact      357

<210>   4296
<211>   119
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903914 (3.E-49)

<400>   4296
Met Ser Ile Ile Leu Thr Thr Ile Val Ala Leu Glu His Phe Tyr Ile 
1               5                   10                  15      

Phe Tyr Leu Glu Ser Ile Ala Thr Gln Ser Asp Ala Thr Ser Arg Val 
            20                  25                  30          

Phe Asn Met Glu Lys Glu Glu Leu Ala His Pro Ser Val Ser Ser Leu 
        35                  40                  45              

Phe Lys Asn Gln Gly Ile Tyr Lys Ala Leu Leu Gly Val Phe Leu Leu 
    50                  55                  60                  

Tyr Val Ile Tyr Phe Ser Gln Asn Leu Glu Ile Val Thr Ile Phe Val 
65                  70                  75                  80  

Leu Phe Val Ile Gly Ala Ala Thr Tyr Gly Ser Leu Thr Ala Asp Lys 
                85                  90                  95      

Lys Ile Ile Leu Lys Gln Gly Gly Ser Ala Ile Leu Ala Leu Ile Ser 
            100                 105                 110         

Ile Leu Leu Phe Lys Tyr Thr 
        115                 

<210>   4297
<211>   423
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4297
atgctagaga ttcaagattt actgtatcaa ctccgcttgt ctgagcaagc gagtacgcaa   60
ttgtttgaaa aaaggcttgg gattagtttg acacggtatc agattttact gtttttgctg   120
gagcattctc cttgtaacca aatggcggtt caggagcgtt tgaaaattga tcaggctgct   180
ttgacacggc atttcaaaat tttggaaacg gaaggtttgg tggagcgtca tcgtaatcct   240
gaaaatcagc gggaagtgtt ggtagaggct gcgaagtatg ccaaggagca gttagtggtg   300
aatccccctc tgcaacatat cagggttaag gaagagatag aaagtatctt aacagagttt   360
gagagaacag aactcagccg tttattaaat aaattggttt tgggtattga aaatatagaa   420
att                                                                 423

<210>   4298
<211>   141
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   transcriptional regulator, MarR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903915 (6.E-58)

<400>   4298
Met Leu Glu Ile Gln Asp Leu Leu Tyr Gln Leu Arg Leu Ser Glu Gln 
1               5                   10                  15      

Ala Ser Thr Gln Leu Phe Glu Lys Arg Leu Gly Ile Ser Leu Thr Arg 
            20                  25                  30          

Tyr Gln Ile Leu Leu Phe Leu Leu Glu His Ser Pro Cys Asn Gln Met 
        35                  40                  45              

Ala Val Gln Glu Arg Leu Lys Ile Asp Gln Ala Ala Leu Thr Arg His 
    50                  55                  60                  

Phe Lys Ile Leu Glu Thr Glu Gly Leu Val Glu Arg His Arg Asn Pro 
65                  70                  75                  80  

Glu Asn Gln Arg Glu Val Leu Val Glu Ala Ala Lys Tyr Ala Lys Glu 
                85                  90                  95      

Gln Leu Val Val Asn Pro Pro Leu Gln His Ile Arg Val Lys Glu Glu 
            100                 105                 110         

Ile Glu Ser Ile Leu Thr Glu Phe Glu Arg Thr Glu Leu Ser Arg Leu 
        115                 120                 125             

Leu Asn Lys Leu Val Leu Gly Ile Glu Asn Ile Glu Ile 
    130                 135                 140     

<210>   4299
<211>   144
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4299
ttgaagtttc agataaaact gacgtggttt gaagagattt tcgaagagta tgacaaagaa   60
aaaacgaacg agaatcgctt tccatcacga aagctagatc tcattcgtca aaatgatgtt   120
atcaagtcgg gtttatccat tcat                                          144

<210>   4300
<211>   48
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4300
Met Lys Phe Gln Ile Lys Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu 
1               5                   10                  15      

Tyr Asp Lys Glu Lys Thr Asn Glu Asn Arg Phe Pro Ser Arg Lys Leu 
            20                  25                  30          

Asp Leu Ile Arg Gln Asn Asp Val Ile Lys Ser Gly Leu Ser Ile His 
        35                  40                  45              


<210>   4301
<211>   1110
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4301
atgaagaaaa gaatgttatt agcgtcaaca gtagccttgt catttgcccc agtattggca   60
actcaagcag aagaagttct ttggactgca cgtagtgttg agcaaatcca aaacgatttg   120
actaaaacgg acaacaaaac aagttatacc gtacagtatg gtgatacttt gagcaccatt   180
gcagaagcct tgggtgtaga tgtcacagtg cttgcgaatc tgaacaaaat cactaatatg   240
gacttgattt tcccagaaac tgttttgaca acgactgtca atgaagcaga agaagtaaca   300
gaagttgaaa tccaaacacc tcaagcagac tctagtgaag aagtgacaac tgcgacagca   360
gatttgacca ctaatcaagt gaccgttgat gatcaaactg ttcaggttgc agacctttct   420
caaccaattg cagaagttac aaagacagtg attgcttctg aagaagtggc accatctacg   480
ggcacttctg tcccagagga gcaaacgacc gaaacaactc gcccagttga agaagcaact   540
cctcaggaaa cgactccagc tgagaagcag gaaacacaag caagccctca agctgcatca   600
gcagtggaag taactacaac aagttcagaa gcaaaagaag tagcatcatc aaatggagct   660
acagcagcag tttctactta tcaaccagaa gagacgaaaa taatttcaac aacttacgag   720
gctccagctg cgcccgatta tgctggactt gcagtagcaa aatctgaaaa tgcaggtctt   780
caaccacaaa cagctgcctt taaagaagaa attgctaact tgtttggcat tacatccttt   840
agtggttatc gtccaggaga cagtggagat cacggaaaag gtttggctat cgactttatg   900
gtaccagaac gttcagaatt aggggataag attgcggaat atgctattca aaatatggcc   960
agccgtggca ttagttacat catctggaaa caacgtttct atgctccatt cgatagcaaa   1020
tatgggccag ctaacacttg gaacccaatg ccagaccgtg gtagtgtgac agaaaatcac   1080
tatgatcacg ttcacgtttc aatgaatgga                                    1110

<210>   4302
<211>   370
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   LysM domain protein, FRAMESHIFT
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903916 (0.E+01)

<400>   4302
Met Lys Lys Arg Met Leu Leu Ala Ser Thr Val Ala Leu Ser Phe Ala 
1               5                   10                  15      

Pro Val Leu Ala Thr Gln Ala Glu Glu Val Leu Trp Thr Ala Arg Ser 
            20                  25                  30          

Val Glu Gln Ile Gln Asn Asp Leu Thr Lys Thr Asp Asn Lys Thr Ser 
        35                  40                  45              

Tyr Thr Val Gln Tyr Gly Asp Thr Leu Ser Thr Ile Ala Glu Ala Leu 
    50                  55                  60                  

Gly Val Asp Val Thr Val Leu Ala Asn Leu Asn Lys Ile Thr Asn Met 
65                  70                  75                  80  

Asp Leu Ile Phe Pro Glu Thr Val Leu Thr Thr Thr Val Asn Glu Ala 
                85                  90                  95      

Glu Glu Val Thr Glu Val Glu Ile Gln Thr Pro Gln Ala Asp Ser Ser 
            100                 105                 110         

Glu Glu Val Thr Thr Ala Thr Ala Asp Leu Thr Thr Asn Gln Val Thr 
        115                 120                 125             

Val Asp Asp Gln Thr Val Gln Val Ala Asp Leu Ser Gln Pro Ile Ala 
    130                 135                 140                 

Glu Val Thr Lys Thr Val Ile Ala Ser Glu Glu Val Ala Pro Ser Thr 
145                 150                 155                 160 

Gly Thr Ser Val Pro Glu Glu Gln Thr Thr Glu Thr Thr Arg Pro Val 
                165                 170                 175     

Glu Glu Ala Thr Pro Gln Glu Thr Thr Pro Ala Glu Lys Gln Glu Thr 
            180                 185                 190         

Gln Ala Ser Pro Gln Ala Ala Ser Ala Val Glu Val Thr Thr Thr Ser 
        195                 200                 205             

Ser Glu Ala Lys Glu Val Ala Ser Ser Asn Gly Ala Thr Ala Ala Val 
    210                 215                 220                 

Ser Thr Tyr Gln Pro Glu Glu Thr Lys Ile Ile Ser Thr Thr Tyr Glu 
225                 230                 235                 240 

Ala Pro Ala Ala Pro Asp Tyr Ala Gly Leu Ala Val Ala Lys Ser Glu 
                245                 250                 255     

Asn Ala Gly Leu Gln Pro Gln Thr Ala Ala Phe Lys Glu Glu Ile Ala 
            260                 265                 270         

Asn Leu Phe Gly Ile Thr Ser Phe Ser Gly Tyr Arg Pro Gly Asp Ser 
        275                 280                 285             

Gly Asp His Gly Lys Gly Leu Ala Ile Asp Phe Met Val Pro Glu Arg 
    290                 295                 300                 

Ser Glu Leu Gly Asp Lys Ile Ala Glu Tyr Ala Ile Gln Asn Met Ala 
305                 310                 315                 320 

Ser Arg Gly Ile Ser Tyr Ile Ile Trp Lys Gln Arg Phe Tyr Ala Pro 
                325                 330                 335     

Phe Asp Ser Lys Tyr Gly Pro Ala Asn Thr Trp Asn Pro Met Pro Asp 
            340                 345                 350         

Arg Gly Ser Val Thr Glu Asn His Tyr Asp His Val His Val Ser Met 
        355                 360                 365             

Asn Gly 
    370 

<210>   4303
<211>   618
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4303
atgcaaaaaa cagcttttat ttgggattta gacgggactt tattggactc ttacgaagcg   60
attttatcag ggattgagga gacttttgct cagttttcta ttccttatga taaggagaag   120
gtgagagagt ttatcttcaa gtattcggtg caagatttgc ttgtgcgggt ggcagaagat   180
agaaatctgg atgttgaggt gctaaatcag gtgcgtgccc agagtctggc tgagaagaat   240
gctcaggtag ttttgatgcc aggtgcgcgt gaggtgctag cttgggcaga cgaatcagga   300
attcagcagt ttatatatac tcataagggg aacaacgctt ttaccattct caaggacttg   360
ggggtggaat cctattttac agagatttta accagtcaga gtggctttgt gcggaagcca   420
agtccagaag cggctaccta tctgctagat aagtatcagt tgaattctga taatacttat   480
tatatagggg atcggactct ggatgtggaa tttgcccaga atagtgggat tcaaagcatc   540
aactttttag agtctactta tgaagggaat cacaggattc aagcgttagc agatatttcc   600
cgtatttttg agactaag                                                 618

<210>   4304
<211>   206
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydrolase, haloacid dehalogenase-like family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903917 (e-115)

<400>   4304
Met Gln Lys Thr Ala Phe Ile Trp Asp Leu Asp Gly Thr Leu Leu Asp 
1               5                   10                  15      

Ser Tyr Glu Ala Ile Leu Ser Gly Ile Glu Glu Thr Phe Ala Gln Phe 
            20                  25                  30          

Ser Ile Pro Tyr Asp Lys Glu Lys Val Arg Glu Phe Ile Phe Lys Tyr 
        35                  40                  45              

Ser Val Gln Asp Leu Leu Val Arg Val Ala Glu Asp Arg Asn Leu Asp 
    50                  55                  60                  

Val Glu Val Leu Asn Gln Val Arg Ala Gln Ser Leu Ala Glu Lys Asn 
65                  70                  75                  80  

Ala Gln Val Val Leu Met Pro Gly Ala Arg Glu Val Leu Ala Trp Ala 
                85                  90                  95      

Asp Glu Ser Gly Ile Gln Gln Phe Ile Tyr Thr His Lys Gly Asn Asn 
            100                 105                 110         

Ala Phe Thr Ile Leu Lys Asp Leu Gly Val Glu Ser Tyr Phe Thr Glu 
        115                 120                 125             

Ile Leu Thr Ser Gln Ser Gly Phe Val Arg Lys Pro Ser Pro Glu Ala 
    130                 135                 140                 

Ala Thr Tyr Leu Leu Asp Lys Tyr Gln Leu Asn Ser Asp Asn Thr Tyr 
145                 150                 155                 160 

Tyr Ile Gly Asp Arg Thr Leu Asp Val Glu Phe Ala Gln Asn Ser Gly 
                165                 170                 175     

Ile Gln Ser Ile Asn Phe Leu Glu Ser Thr Tyr Glu Gly Asn His Arg 
            180                 185                 190         

Ile Gln Ala Leu Ala Asp Ile Ser Arg Ile Phe Glu Thr Lys 
        195                 200                 205     

<210>   4305
<211>   1233
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4305
atgggtgaaa actttttgca gatgctaatg ggaatggtgg acagttattt ggttgctcat   60
ttaggattga tagctatttc aggggtttca gtagctggta atattatcac catttatcag   120
gcgattttca tcgctctggg agctgctatt tccagtgtta tttcaaaaag catagggcag   180
aaagaccagt cgaagttggc ctatcatgtg actgaggcgt tgaagattac cttactatta   240
agtttccttt taggattttt gtccatcttc gctgggaaag agatgatagg acttttgggg   300
acggagaggg atgtagctga gagtggtgga ctgtatctat ctttggtagg cggatcgatt   360
gttctcttag gtttaatgac tagtctagga gccttgattc gtgcaacgca taatccacgt   420
ctgcctctct atgttagttt tttatccaat gccttgaata ttcttttttc aagtctagct   480
atttttgttc tggatatggg gatagctggt gttgcttggg ggacaattgt gtctcgtttg   540
gttggtcttg tgattttgtg gtcacaatta aaactgcctt atgggaagcc aacttttggt   600
ttagataagg aactgttgac cttggcttta ccagcagctg gagagcgact tatgatgagg   660
gctggagatg tagtgatcat tgccttggtc gtttcttttg ggacggaggc agttgctggg   720
aatgcaatcg gagaagtctt gacccagttt aactatatgc ctgcctttgg cgtcgctacg   780
gcaacggtca tgctgttggc ccgagcagtt ggagaggatg attggaaaag agttgctagt   840
ttgagtaaac aaaccttttg gctttctctg ttcctcatgt tgcccctgtc ctttagtata   900
tatgtcttgg gtgtaccatt aactcatctc tatacgactg attctctagc ggtggaggct   960
agtgttctag tgacactgtt ttcactactt gggaccccta tgacgacagg aacagtcatc   1020
tatacggcag tctggcaggg attaggaaat gcacgcctcc ctttttatgc gacaagtata   1080
ggaatgtggt gtatccgcat tgggacagga tatctgatgg ggattgtgct tggttggggc   1140
ttgcctggta tttgggcagg gtctctcttg gataatggtt ttcgctggtt atttctacgc   1200
tatcgttacc agcgctatat gagcttgaaa gga                                1233

<210>   4306
<211>   411
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MATE efflux family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903918 (0.E+01)

<400>   4306
Met Gly Glu Asn Phe Leu Gln Met Leu Met Gly Met Val Asp Ser Tyr 
1               5                   10                  15      

Leu Val Ala His Leu Gly Leu Ile Ala Ile Ser Gly Val Ser Val Ala 
            20                  25                  30          

Gly Asn Ile Ile Thr Ile Tyr Gln Ala Ile Phe Ile Ala Leu Gly Ala 
        35                  40                  45              

Ala Ile Ser Ser Val Ile Ser Lys Ser Ile Gly Gln Lys Asp Gln Ser 
    50                  55                  60                  

Lys Leu Ala Tyr His Val Thr Glu Ala Leu Lys Ile Thr Leu Leu Leu 
65                  70                  75                  80  

Ser Phe Leu Leu Gly Phe Leu Ser Ile Phe Ala Gly Lys Glu Met Ile 
                85                  90                  95      

Gly Leu Leu Gly Thr Glu Arg Asp Val Ala Glu Ser Gly Gly Leu Tyr 
            100                 105                 110         

Leu Ser Leu Val Gly Gly Ser Ile Val Leu Leu Gly Leu Met Thr Ser 
        115                 120                 125             

Leu Gly Ala Leu Ile Arg Ala Thr His Asn Pro Arg Leu Pro Leu Tyr 
    130                 135                 140                 

Val Ser Phe Leu Ser Asn Ala Leu Asn Ile Leu Phe Ser Ser Leu Ala 
145                 150                 155                 160 

Ile Phe Val Leu Asp Met Gly Ile Ala Gly Val Ala Trp Gly Thr Ile 
                165                 170                 175     

Val Ser Arg Leu Val Gly Leu Val Ile Leu Trp Ser Gln Leu Lys Leu 
            180                 185                 190         

Pro Tyr Gly Lys Pro Thr Phe Gly Leu Asp Lys Glu Leu Leu Thr Leu 
        195                 200                 205             

Ala Leu Pro Ala Ala Gly Glu Arg Leu Met Met Arg Ala Gly Asp Val 
    210                 215                 220                 

Val Ile Ile Ala Leu Val Val Ser Phe Gly Thr Glu Ala Val Ala Gly 
225                 230                 235                 240 

Asn Ala Ile Gly Glu Val Leu Thr Gln Phe Asn Tyr Met Pro Ala Phe 
                245                 250                 255     

Gly Val Ala Thr Ala Thr Val Met Leu Leu Ala Arg Ala Val Gly Glu 
            260                 265                 270         

Asp Asp Trp Lys Arg Val Ala Ser Leu Ser Lys Gln Thr Phe Trp Leu 
        275                 280                 285             

Ser Leu Phe Leu Met Leu Pro Leu Ser Phe Ser Ile Tyr Val Leu Gly 
    290                 295                 300                 

Val Pro Leu Thr His Leu Tyr Thr Thr Asp Ser Leu Ala Val Glu Ala 
305                 310                 315                 320 

Ser Val Leu Val Thr Leu Phe Ser Leu Leu Gly Thr Pro Met Thr Thr 
                325                 330                 335     

Gly Thr Val Ile Tyr Thr Ala Val Trp Gln Gly Leu Gly Asn Ala Arg 
            340                 345                 350         

Leu Pro Phe Tyr Ala Thr Ser Ile Gly Met Trp Cys Ile Arg Ile Gly 
        355                 360                 365             

Thr Gly Tyr Leu Met Gly Ile Val Leu Gly Trp Gly Leu Pro Gly Ile 
    370                 375                 380                 

Trp Ala Gly Ser Leu Leu Asp Asn Gly Phe Arg Trp Leu Phe Leu Arg 
385                 390                 395                 400 

Tyr Arg Tyr Gln Arg Tyr Met Ser Leu Lys Gly 
                405                 410     

<210>   4307
<211>   1482
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4307
atgacattag tttatcaatc aacgcgtgat gccaacaata cagtaactgc cagccaagca   60
attttgcaag gtttggcgac ggacggcggt ttgtttacac cggatactta tccaaaggta   120
gatttgaact ttgacaaatt gaaagatgct tcttaccagg aagttgctaa gctagttttg   180
tcagcatttt tagatgactt tacagttgag gagttggact actgtatcaa caatgcctac   240
gatagcaaat ttgatactcc agctattgca ccattagtga aattagatgg gcaatacaat   300
ttggaacttt tccatggttc aacgattgcc tttaaggata tggccttgtc tattttgcca   360
tactttatga cgactgctgc taagaaacat ggtttggaga acaagattgt tatcttgaca   420
gcgacatctg gtgacacggg gaaagctgct atggcggggt ttgcgaatgt gcctggtact   480
gagattatcg tcttttatcc aaaggatggt gtcagcaaga ttcaagagtt acaaatgacc   540
actcagactg gcgacaatac tcatgttatt gctattgatg gtaactttga cgatgcgcaa   600
acaaatgtga agcacatgtt taacgacgtg gctcttcgtg aaaaattgac taccaacaag   660
ttgcaatttt catcagctaa ctctatgaac attggtcgtc tggtgccaca aattgtttat   720
tatgtttatg cttacgctca attggttaag actggtgaaa ttgtagctgg tgaaaaggtt   780
aacttcacag taccaacagg aaactttgga aatatcttgg ctgcctttta tgccaaacaa   840
attggtttgc cagttggtaa attaatctgt gcttcaaatg acaacaatgt tttgacagac   900
ttctttaaaa cacgtgtcta tgacaaaaaa cgtgagttta aggtaacaac cagcccatct   960
atggatatct tggtatcttc aaacttggag cgcttgattt tccatctttt gggaaataat   1020
gctgaaaaga caactgaact tatgaatgcc ttgaacacgc aaggacaata taagttgaca   1080
gactttgatg cagagatttt ggacctcttt gcagctgaat atgcgactga ggaagaaacg   1140
gcagcagaga tcaagcgtgt ttgtgagtta gattcttata tcgaggaccc tcatacagct   1200
gttgcttcag cagtttataa aaaataccaa tcggccactg gagatgtaac taagacagtg   1260
attgcttcaa cagctagtcc atacaagttc ccagtagttg cagtagaagc tgtaactgga   1320
aaagcaggtt taacagactt tgaagccttg gctcaattac atgaaatctc aggcgttgca   1380
gtgccaccag cagttgatgg gcttgaaata gctccaattc gtcacaagac aacagtggca   1440
gctgctgaca tgcaagcagc ggttgaggct tatttaggac tt                      1482

<210>   4308
<211>   494
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   threonine synthase (thrC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903919 (0.E+01)

<400>   4308
Met Thr Leu Val Tyr Gln Ser Thr Arg Asp Ala Asn Asn Thr Val Thr 
1               5                   10                  15      

Ala Ser Gln Ala Ile Leu Gln Gly Leu Ala Thr Asp Gly Gly Leu Phe 
            20                  25                  30          

Thr Pro Asp Thr Tyr Pro Lys Val Asp Leu Asn Phe Asp Lys Leu Lys 
        35                  40                  45              

Asp Ala Ser Tyr Gln Glu Val Ala Lys Leu Val Leu Ser Ala Phe Leu 
    50                  55                  60                  

Asp Asp Phe Thr Val Glu Glu Leu Asp Tyr Cys Ile Asn Asn Ala Tyr 
65                  70                  75                  80  

Asp Ser Lys Phe Asp Thr Pro Ala Ile Ala Pro Leu Val Lys Leu Asp 
                85                  90                  95      

Gly Gln Tyr Asn Leu Glu Leu Phe His Gly Ser Thr Ile Ala Phe Lys 
            100                 105                 110         

Asp Met Ala Leu Ser Ile Leu Pro Tyr Phe Met Thr Thr Ala Ala Lys 
        115                 120                 125             

Lys His Gly Leu Glu Asn Lys Ile Val Ile Leu Thr Ala Thr Ser Gly 
    130                 135                 140                 

Asp Thr Gly Lys Ala Ala Met Ala Gly Phe Ala Asn Val Pro Gly Thr 
145                 150                 155                 160 

Glu Ile Ile Val Phe Tyr Pro Lys Asp Gly Val Ser Lys Ile Gln Glu 
                165                 170                 175     

Leu Gln Met Thr Thr Gln Thr Gly Asp Asn Thr His Val Ile Ala Ile 
            180                 185                 190         

Asp Gly Asn Phe Asp Asp Ala Gln Thr Asn Val Lys His Met Phe Asn 
        195                 200                 205             

Asp Val Ala Leu Arg Glu Lys Leu Thr Thr Asn Lys Leu Gln Phe Ser 
    210                 215                 220                 

Ser Ala Asn Ser Met Asn Ile Gly Arg Leu Val Pro Gln Ile Val Tyr 
225                 230                 235                 240 

Tyr Val Tyr Ala Tyr Ala Gln Leu Val Lys Thr Gly Glu Ile Val Ala 
                245                 250                 255     

Gly Glu Lys Val Asn Phe Thr Val Pro Thr Gly Asn Phe Gly Asn Ile 
            260                 265                 270         

Leu Ala Ala Phe Tyr Ala Lys Gln Ile Gly Leu Pro Val Gly Lys Leu 
        275                 280                 285             

Ile Cys Ala Ser Asn Asp Asn Asn Val Leu Thr Asp Phe Phe Lys Thr 
    290                 295                 300                 

Arg Val Tyr Asp Lys Lys Arg Glu Phe Lys Val Thr Thr Ser Pro Ser 
305                 310                 315                 320 

Met Asp Ile Leu Val Ser Ser Asn Leu Glu Arg Leu Ile Phe His Leu 
                325                 330                 335     

Leu Gly Asn Asn Ala Glu Lys Thr Thr Glu Leu Met Asn Ala Leu Asn 
            340                 345                 350         

Thr Gln Gly Gln Tyr Lys Leu Thr Asp Phe Asp Ala Glu Ile Leu Asp 
        355                 360                 365             

Leu Phe Ala Ala Glu Tyr Ala Thr Glu Glu Glu Thr Ala Ala Glu Ile 
    370                 375                 380                 

Lys Arg Val Cys Glu Leu Asp Ser Tyr Ile Glu Asp Pro His Thr Ala 
385                 390                 395                 400 

Val Ala Ser Ala Val Tyr Lys Lys Tyr Gln Ser Ala Thr Gly Asp Val 
                405                 410                 415     

Thr Lys Thr Val Ile Ala Ser Thr Ala Ser Pro Tyr Lys Phe Pro Val 
            420                 425                 430         

Val Ala Val Glu Ala Val Thr Gly Lys Ala Gly Leu Thr Asp Phe Glu 
        435                 440                 445             

Ala Leu Ala Gln Leu His Glu Ile Ser Gly Val Ala Val Pro Pro Ala 
    450                 455                 460                 

Val Asp Gly Leu Glu Ile Ala Pro Ile Arg His Lys Thr Thr Val Ala 
465                 470                 475                 480 

Ala Ala Asp Met Gln Ala Ala Val Glu Ala Tyr Leu Gly Leu 
                485                 490                 

<210>   4309
<211>   1275
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4309
atgtcttgtt ctatcgattt attaaaacat cggtatttga aaaatattaa agaaaatcct   60
gaattgtttg tcggaattga gttggagtat cctgttgcaa gtttagaagg ggatgctaca   120
gatgttgaag ttatgaagga tctatttcat tatttagttt ctactttgga tctcaccgta   180
gcaaaggtag atgattttgg caatctgatc cagttagtag atccgataag tcaggatgct   240
attttatttg aagtttccta tacaacgatt gagtttgcat ttggtaaggc tgaaacgatt   300
caagaggtcg aaaatcgttt caataattat atgaatgtaa ttcagagaaa gttagctgaa   360
tcaaatcatg ctattgttgg ctgtggtatc catcccaact gggataaaaa tgagaattgt   420
ccagtggctt atccacgcta tcagatgttg atggattatt tgaatttgag tagaaatatt   480
attaaatcag atttacatca tttccctgaa tatggtactt ttatctgtgg gagccaggtt   540
cagctggata tttcaaaaac caactactta cgggtgatta atgcttttac tcaaattgaa   600
gcggctaagg cttatttatt tgcaaactct gaattttcgg gtgcggattg ggatacgaaa   660
atttcaaggg atattttctg ggaagaatct atgcatggta tctatccaga gaatgttggg   720
gtcaatgcta gactccttaa tgatgaaact gatttttttg actatctaaa tcattctgcg   780
atttttactg cggaacgtga tgggcagacc tattattttt atcctattca ggctggggac   840
tatttggcta cgtccgaaat ccaagcattt gctctgaatg gggatgaggt tattatttac   900
ccccaagaga aggattttga aactcatcgt agttaccagt accaagattt aacgactcga   960
ggaacagttg agtttcgtag tgtgtgtaca cagccacttg ataggacttt tgcttctgca   1020
gcttttcact tgggattatt ggttaattta gacaagttag aagcttactt agaaacagca   1080
cctttcttta aagtatttgg ttatgattac aagtctttaa ggagacaatt ttctaagaaa   1140
aatcttacag atgaggaaga aactacgatt attgaatttt ccaaagactt actcctacta   1200
gctgaggagg gactagtggt gagaaataag gaagaaatga cctatttaca gcctttgaga   1260
gaagaattga gccta                                                    1275

<210>   4310
<211>   425
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903920 (0.E+01)

<400>   4310
Met Ser Cys Ser Ile Asp Leu Leu Lys His Arg Tyr Leu Lys Asn Ile 
1               5                   10                  15      

Lys Glu Asn Pro Glu Leu Phe Val Gly Ile Glu Leu Glu Tyr Pro Val 
            20                  25                  30          

Ala Ser Leu Glu Gly Asp Ala Thr Asp Val Glu Val Met Lys Asp Leu 
        35                  40                  45              

Phe His Tyr Leu Val Ser Thr Leu Asp Leu Thr Val Ala Lys Val Asp 
    50                  55                  60                  

Asp Phe Gly Asn Leu Ile Gln Leu Val Asp Pro Ile Ser Gln Asp Ala 
65                  70                  75                  80  

Ile Leu Phe Glu Val Ser Tyr Thr Thr Ile Glu Phe Ala Phe Gly Lys 
                85                  90                  95      

Ala Glu Thr Ile Gln Glu Val Glu Asn Arg Phe Asn Asn Tyr Met Asn 
            100                 105                 110         

Val Ile Gln Arg Lys Leu Ala Glu Ser Asn His Ala Ile Val Gly Cys 
        115                 120                 125             

Gly Ile His Pro Asn Trp Asp Lys Asn Glu Asn Cys Pro Val Ala Tyr 
    130                 135                 140                 

Pro Arg Tyr Gln Met Leu Met Asp Tyr Leu Asn Leu Ser Arg Asn Ile 
145                 150                 155                 160 

Ile Lys Ser Asp Leu His His Phe Pro Glu Tyr Gly Thr Phe Ile Cys 
                165                 170                 175     

Gly Ser Gln Val Gln Leu Asp Ile Ser Lys Thr Asn Tyr Leu Arg Val 
            180                 185                 190         

Ile Asn Ala Phe Thr Gln Ile Glu Ala Ala Lys Ala Tyr Leu Phe Ala 
        195                 200                 205             

Asn Ser Glu Phe Ser Gly Ala Asp Trp Asp Thr Lys Ile Ser Arg Asp 
    210                 215                 220                 

Ile Phe Trp Glu Glu Ser Met His Gly Ile Tyr Pro Glu Asn Val Gly 
225                 230                 235                 240 

Val Asn Ala Arg Leu Leu Asn Asp Glu Thr Asp Phe Phe Asp Tyr Leu 
                245                 250                 255     

Asn His Ser Ala Ile Phe Thr Ala Glu Arg Asp Gly Gln Thr Tyr Tyr 
            260                 265                 270         

Phe Tyr Pro Ile Gln Ala Gly Asp Tyr Leu Ala Thr Ser Glu Ile Gln 
        275                 280                 285             

Ala Phe Ala Leu Asn Gly Asp Glu Val Ile Ile Tyr Pro Gln Glu Lys 
    290                 295                 300                 

Asp Phe Glu Thr His Arg Ser Tyr Gln Tyr Gln Asp Leu Thr Thr Arg 
305                 310                 315                 320 

Gly Thr Val Glu Phe Arg Ser Val Cys Thr Gln Pro Leu Asp Arg Thr 
                325                 330                 335     

Phe Ala Ser Ala Ala Phe His Leu Gly Leu Leu Val Asn Leu Asp Lys 
            340                 345                 350         

Leu Glu Ala Tyr Leu Glu Thr Ala Pro Phe Phe Lys Val Phe Gly Tyr 
        355                 360                 365             

Asp Tyr Lys Ser Leu Arg Arg Gln Phe Ser Lys Lys Asn Leu Thr Asp 
    370                 375                 380                 

Glu Glu Glu Thr Thr Ile Ile Glu Phe Ser Lys Asp Leu Leu Leu Leu 
385                 390                 395                 400 

Ala Glu Glu Gly Leu Val Val Arg Asn Lys Glu Glu Met Thr Tyr Leu 
                405                 410                 415     

Gln Pro Leu Arg Glu Glu Leu Ser Leu 
            420                 425 

<210>   4311
<211>   432
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4311
atggacatct gggaaaagat gtacgaagaa gcacagaaac tatacaatcc acatgaagta   60
tcagactttg tttatgccaa tcatgttgta gctgcagtag aagcaggaga tggacaaata   120
tttacaggat tctgtatgga gggaacctgt ggtgttttcc atctctgcgc agaacgggcg   180
gccctcttca atatgtacca attttcagga caaactaagg ttaagaaagt attagccttt   240
cgagacaaac caccttatgg tggaagttca gccatgcctt gcggtgcttg tagagaattc   300
cttttagagc ttaatgctga aaataaagat gcagaattca tgatggacta taatataaga   360
aaaacagtta aagtcgcaga actaatccct tattggtggg gaaaagaacg tgcttctaag   420
tttaatgagc ga                                                       432

<210>   4312
<211>   144
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cytidine/deoxycytidylate deaminase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903921 (1.E-83)

<400>   4312
Met Asp Ile Trp Glu Lys Met Tyr Glu Glu Ala Gln Lys Leu Tyr Asn 
1               5                   10                  15      

Pro His Glu Val Ser Asp Phe Val Tyr Ala Asn His Val Val Ala Ala 
            20                  25                  30          

Val Glu Ala Gly Asp Gly Gln Ile Phe Thr Gly Phe Cys Met Glu Gly 
        35                  40                  45              

Thr Cys Gly Val Phe His Leu Cys Ala Glu Arg Ala Ala Leu Phe Asn 
    50                  55                  60                  

Met Tyr Gln Phe Ser Gly Gln Thr Lys Val Lys Lys Val Leu Ala Phe 
65                  70                  75                  80  

Arg Asp Lys Pro Pro Tyr Gly Gly Ser Ser Ala Met Pro Cys Gly Ala 
                85                  90                  95      

Cys Arg Glu Phe Leu Leu Glu Leu Asn Ala Glu Asn Lys Asp Ala Glu 
            100                 105                 110         

Phe Met Met Asp Tyr Asn Ile Arg Lys Thr Val Lys Val Ala Glu Leu 
        115                 120                 125             

Ile Pro Tyr Trp Trp Gly Lys Glu Arg Ala Ser Lys Phe Asn Glu Arg 
    130                 135                 140                 


<210>   4313
<211>   1458
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4313
atgtcaaaag atatccgcgt acgttacgca ccaagtccaa caggactact acacatcgga   60
aatgctcgta cagcattgtt taattacttg tatgcgcgcc atcatggtgg aacatttctc   120
atccgtatcg aagatactga ccgtaaacgc catgtcgagg atggtgaacg ttcacaactt   180
gaaaaccttc gctggttagg catggattgg gatgaaagtc cagaatcaca tgagaattat   240
cgccagtctg agcgtttgga cttgtatcaa aaatatattg accaactatt agctgaagga   300
aaagcctata aatcttacgt tacagaagaa gagttggcag ctgaacgcga acgccaagaa   360
gtagctggcg aaacaccacg ctacatcaat gaataccttg gtatgagtga agaagaaaaa   420
gcagcttaca tcgcagaacg tgaagcagca gggatcatcc caactgttcg tttggctgtc   480
aatgagtcag gtatctacaa gtggcatgat atggtcaaag gcgatatcga atttgaaggt   540
ggcaatatcg gtggtgactg ggttatccaa aagaaagacg gttacccaac ttacaacttt   600
gccgttgtta tcgatgacca cgatatgcaa atctctcatg ttatccgtgg agatgaccat   660
attgctaata caccaaaaca gcttatggtc tatgaagctc ttggttggga agctccagag   720
ttcggtcaca tgaccttgat tatcaactct gaaactggta agaagttatc taaacgtgat   780
actaatacac ttcaatttat cgaagattac cgaaagaaag gttaccttcc agaagcagtc   840
tttaacttta ttgctcttct tggttggaac ccaggtggtg aagatgagat tttctctcgt   900
gaagaattca ttaaactttt tgatgaaaac cgcctcagca agtcaccagc agcctttgat   960
cagaaaaaac tagactggat gagcaatgat tatatcaaga atgcagacct tgaaaccatc   1020
tttgaaatgg caaaaccatt cttagaggaa gcaggccgtt tgactgacaa ggctgaaaaa   1080
ttagttgagc tctataaacc acaaatgaaa tcagtagatg agattatccc attgacagat   1140
cttttcttct cagatttccc agaattgaca gaagcagagc gcgaagtcat gacgggtgaa   1200
acagttccaa cagttcttga agcattcaaa gcaaaacttg aagcgatgac agatgatgaa   1260
tttgtgacag aaaatatctt cccacaaatt aaagcagtcc aaaaagaaac aggtattaaa   1320
gggaaaaatc ttttcatgcc tattcgtatc gcagtttcag gcgaaatgca tgggccagaa   1380
ttaccagata caattttctt gcttggacgt gaaaaatcaa ttcagcatat cgaaaacatg   1440
ctaaaagaaa tctctaaa                                                 1458

<210>   4314
<211>   486
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamyl-tRNA synthetase (gltX)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903922 (0.E+01)

<400>   4314
Met Ser Lys Asp Ile Arg Val Arg Tyr Ala Pro Ser Pro Thr Gly Leu 
1               5                   10                  15      

Leu His Ile Gly Asn Ala Arg Thr Ala Leu Phe Asn Tyr Leu Tyr Ala 
            20                  25                  30          

Arg His His Gly Gly Thr Phe Leu Ile Arg Ile Glu Asp Thr Asp Arg 
        35                  40                  45              

Lys Arg His Val Glu Asp Gly Glu Arg Ser Gln Leu Glu Asn Leu Arg 
    50                  55                  60                  

Trp Leu Gly Met Asp Trp Asp Glu Ser Pro Glu Ser His Glu Asn Tyr 
65                  70                  75                  80  

Arg Gln Ser Glu Arg Leu Asp Leu Tyr Gln Lys Tyr Ile Asp Gln Leu 
                85                  90                  95      

Leu Ala Glu Gly Lys Ala Tyr Lys Ser Tyr Val Thr Glu Glu Glu Leu 
            100                 105                 110         

Ala Ala Glu Arg Glu Arg Gln Glu Val Ala Gly Glu Thr Pro Arg Tyr 
        115                 120                 125             

Ile Asn Glu Tyr Leu Gly Met Ser Glu Glu Glu Lys Ala Ala Tyr Ile 
    130                 135                 140                 

Ala Glu Arg Glu Ala Ala Gly Ile Ile Pro Thr Val Arg Leu Ala Val 
145                 150                 155                 160 

Asn Glu Ser Gly Ile Tyr Lys Trp His Asp Met Val Lys Gly Asp Ile 
                165                 170                 175     

Glu Phe Glu Gly Gly Asn Ile Gly Gly Asp Trp Val Ile Gln Lys Lys 
            180                 185                 190         

Asp Gly Tyr Pro Thr Tyr Asn Phe Ala Val Val Ile Asp Asp His Asp 
        195                 200                 205             

Met Gln Ile Ser His Val Ile Arg Gly Asp Asp His Ile Ala Asn Thr 
    210                 215                 220                 

Pro Lys Gln Leu Met Val Tyr Glu Ala Leu Gly Trp Glu Ala Pro Glu 
225                 230                 235                 240 

Phe Gly His Met Thr Leu Ile Ile Asn Ser Glu Thr Gly Lys Lys Leu 
                245                 250                 255     

Ser Lys Arg Asp Thr Asn Thr Leu Gln Phe Ile Glu Asp Tyr Arg Lys 
            260                 265                 270         

Lys Gly Tyr Leu Pro Glu Ala Val Phe Asn Phe Ile Ala Leu Leu Gly 
        275                 280                 285             

Trp Asn Pro Gly Gly Glu Asp Glu Ile Phe Ser Arg Glu Glu Phe Ile 
    290                 295                 300                 

Lys Leu Phe Asp Glu Asn Arg Leu Ser Lys Ser Pro Ala Ala Phe Asp 
305                 310                 315                 320 

Gln Lys Lys Leu Asp Trp Met Ser Asn Asp Tyr Ile Lys Asn Ala Asp 
                325                 330                 335     

Leu Glu Thr Ile Phe Glu Met Ala Lys Pro Phe Leu Glu Glu Ala Gly 
            340                 345                 350         

Arg Leu Thr Asp Lys Ala Glu Lys Leu Val Glu Leu Tyr Lys Pro Gln 
        355                 360                 365             

Met Lys Ser Val Asp Glu Ile Ile Pro Leu Thr Asp Leu Phe Phe Ser 
    370                 375                 380                 

Asp Phe Pro Glu Leu Thr Glu Ala Glu Arg Glu Val Met Thr Gly Glu 
385                 390                 395                 400 

Thr Val Pro Thr Val Leu Glu Ala Phe Lys Ala Lys Leu Glu Ala Met 
                405                 410                 415     

Thr Asp Asp Glu Phe Val Thr Glu Asn Ile Phe Pro Gln Ile Lys Ala 
            420                 425                 430         

Val Gln Lys Glu Thr Gly Ile Lys Gly Lys Asn Leu Phe Met Pro Ile 
        435                 440                 445             

Arg Ile Ala Val Ser Gly Glu Met His Gly Pro Glu Leu Pro Asp Thr 
    450                 455                 460                 

Ile Phe Leu Leu Gly Arg Glu Lys Ser Ile Gln His Ile Glu Asn Met 
465                 470                 475                 480 

Leu Lys Glu Ile Ser Lys 
                485     

<210>   4315
<211>   1347
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4315
atgtcacata ttaaatttga ttattcaaaa gttttagaca aatttgttgc accacatgaa   60
gtggaataca tgcaatcaca agtaacagca gcagatgaat taatccgtaa aggaactggt   120
gctggtagcg acttcttggg atggttggac cttcctgaaa aatacgaccg cgaagaattt   180
gaccgcatct tgaaagctgc tgagcaaatc aagtcagaca gcgatgtttt ggttgtgatc   240
ggtattggtg gatcttacct tggtgcaaaa gcagcaatcg acttcttgaa tcaccatttt   300
gctaacttgc aaacaaaaga agaacgcaaa gctccacaaa tcctttacgc aggaaactca   360
atctcatcta cttaccttgc tgacttggta gagtatgttg cagacaaaga cttctcagta   420
aacgtaattt ctaaatcagg tacaacaact gaaccagcga ttgctttccg tgtctttaaa   480
gaactcttgg ttaagaaata cggtcaagaa gaagctaaca aacgtatcta tgcaacaact   540
gaccgccaaa agggtgctgt taaggttgaa gcagacgcta acggttgggg aacatttgtt   600
gttccagatg atatcggtgg acgcttctca gtattgacag ccgttggttt gctttcaatc   660
gcagcatcag gagctgacat aaaagctctt atggaaggtg cgaatgcagc tcgcaaagac   720
tacacttcag acaaaatctc tgaaaacgaa gcttaccaat acgcagctgt tcgtaacatc   780
ctttatcgta aaggctatgc aactgagatc ttggtaaact atgagccatc acttcaatac   840
ttctcagaat ggtggaaaca attggctggt gaatcagaag gaaaagacca aaaaggtatc   900
tacccaactt cagccaactt ctcaactgac ttgcactcac ttggtcaatt tatccaagaa   960
ggaactcgta tcatgtttga aacagttgtc cgtgttgaca aacctcgtaa aaacgtgctt   1020
attcctactt tggaagaaga ccttgacgga cttggttacc ttcaaggaaa agacgttgac   1080
tttgtaaaca aaaaagcaac tgacggtgtt cttcttgccc acacagatgg tgatgtacca   1140
aacatgtatg tgactcttcc agagcaagac gctttcactc ttggttacac tatctacttc   1200
ttcgaattgg caattgccct ttcaggttac ttgaatgcta tcaacccatt tgaccaacca   1260
ggtgttgaag cttataaacg taacatgttt gcccttcttg gaaaaccagg atttgaagaa   1320
ttgagcaaag aacttaacgc acgtcta                                       1347

<210>   4316
<211>   449
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glucose-6-phosphate isomerase (pgi)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903923 (0.E+01)

<400>   4316
Met Ser His Ile Lys Phe Asp Tyr Ser Lys Val Leu Asp Lys Phe Val 
1               5                   10                  15      

Ala Pro His Glu Val Glu Tyr Met Gln Ser Gln Val Thr Ala Ala Asp 
            20                  25                  30          

Glu Leu Ile Arg Lys Gly Thr Gly Ala Gly Ser Asp Phe Leu Gly Trp 
        35                  40                  45              

Leu Asp Leu Pro Glu Lys Tyr Asp Arg Glu Glu Phe Asp Arg Ile Leu 
    50                  55                  60                  

Lys Ala Ala Glu Gln Ile Lys Ser Asp Ser Asp Val Leu Val Val Ile 
65                  70                  75                  80  

Gly Ile Gly Gly Ser Tyr Leu Gly Ala Lys Ala Ala Ile Asp Phe Leu 
                85                  90                  95      

Asn His His Phe Ala Asn Leu Gln Thr Lys Glu Glu Arg Lys Ala Pro 
            100                 105                 110         

Gln Ile Leu Tyr Ala Gly Asn Ser Ile Ser Ser Thr Tyr Leu Ala Asp 
        115                 120                 125             

Leu Val Glu Tyr Val Ala Asp Lys Asp Phe Ser Val Asn Val Ile Ser 
    130                 135                 140                 

Lys Ser Gly Thr Thr Thr Glu Pro Ala Ile Ala Phe Arg Val Phe Lys 
145                 150                 155                 160 

Glu Leu Leu Val Lys Lys Tyr Gly Gln Glu Glu Ala Asn Lys Arg Ile 
                165                 170                 175     

Tyr Ala Thr Thr Asp Arg Gln Lys Gly Ala Val Lys Val Glu Ala Asp 
            180                 185                 190         

Ala Asn Gly Trp Gly Thr Phe Val Val Pro Asp Asp Ile Gly Gly Arg 
        195                 200                 205             

Phe Ser Val Leu Thr Ala Val Gly Leu Leu Ser Ile Ala Ala Ser Gly 
    210                 215                 220                 

Ala Asp Ile Lys Ala Leu Met Glu Gly Ala Asn Ala Ala Arg Lys Asp 
225                 230                 235                 240 

Tyr Thr Ser Asp Lys Ile Ser Glu Asn Glu Ala Tyr Gln Tyr Ala Ala 
                245                 250                 255     

Val Arg Asn Ile Leu Tyr Arg Lys Gly Tyr Ala Thr Glu Ile Leu Val 
            260                 265                 270         

Asn Tyr Glu Pro Ser Leu Gln Tyr Phe Ser Glu Trp Trp Lys Gln Leu 
        275                 280                 285             

Ala Gly Glu Ser Glu Gly Lys Asp Gln Lys Gly Ile Tyr Pro Thr Ser 
    290                 295                 300                 

Ala Asn Phe Ser Thr Asp Leu His Ser Leu Gly Gln Phe Ile Gln Glu 
305                 310                 315                 320 

Gly Thr Arg Ile Met Phe Glu Thr Val Val Arg Val Asp Lys Pro Arg 
                325                 330                 335     

Lys Asn Val Leu Ile Pro Thr Leu Glu Glu Asp Leu Asp Gly Leu Gly 
            340                 345                 350         

Tyr Leu Gln Gly Lys Asp Val Asp Phe Val Asn Lys Lys Ala Thr Asp 
        355                 360                 365             

Gly Val Leu Leu Ala His Thr Asp Gly Asp Val Pro Asn Met Tyr Val 
    370                 375                 380                 

Thr Leu Pro Glu Gln Asp Ala Phe Thr Leu Gly Tyr Thr Ile Tyr Phe 
385                 390                 395                 400 

Phe Glu Leu Ala Ile Ala Leu Ser Gly Tyr Leu Asn Ala Ile Asn Pro 
                405                 410                 415     

Phe Asp Gln Pro Gly Val Glu Ala Tyr Lys Arg Asn Met Phe Ala Leu 
            420                 425                 430         

Leu Gly Lys Pro Gly Phe Glu Glu Leu Ser Lys Glu Leu Asn Ala Arg 
        435                 440                 445             

Leu 
    

<210>   4317
<211>   177
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4317
ttggaacatc tggtcgttct ttcttttatt ttttcaaaat ttttagaatg tggcatttta   60
cgcaaacgtt tgaattctga taaaaattgg agaaattcga caaaaaaact tgaaaaaaac   120
gaaggtaagc gttatgatag aaaagaagaa atattggagg aagaacatgt cacatat      177

<210>   4318
<211>   59
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903924 (8.E-31)

<400>   4318
Met Glu His Leu Val Val Leu Ser Phe Ile Phe Ser Lys Phe Leu Glu 
1               5                   10                  15      

Cys Gly Ile Leu Arg Lys Arg Leu Asn Ser Asp Lys Asn Trp Arg Asn 
            20                  25                  30          

Ser Thr Lys Lys Leu Glu Lys Asn Glu Gly Lys Arg Tyr Asp Arg Lys 
        35                  40                  45              

Glu Glu Ile Leu Glu Glu Glu His Val Thr Tyr 
    50                  55                  

<210>   4319
<211>   726
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4319
atgataggac tatcgttagc attcgaaagg agaggcatca tggctagaac ggttgtagga   60
gttgctgcaa atctatgtcc cgtagacgca gaaggcaaaa tcattcattc atctgtatct   120
tgtagattcg cagagatcat tcgtcaagtc ggtggtctcc ctttagtcat tcctgttggt   180
gatgagtcag ttgtacgtga ttatgtggaa atgattgaca aactcatttt gacaggaggc   240
caaaatgttc atcctcagtt ttatggagag aaaaagaccg tcgagagcga tgattacaat   300
ctggtccgtg acgaatttga attggcactc ttgaaggaag cgcttcgtca gaataaacca   360
attatggcaa tctgtcgcgg tgtccaactt gtcaatgttg cctttggtgg aaccctcaat   420
caagaaatcg aaggtcactg gcaaggacta cctttcggga catctcactc tattgagaca   480
gtagaaggaa gcgtggtggc taagctattt gggaaagaaa gtcaggtcaa ctcagtccat   540
cgtcaaagca ttaaagattt ggcacctaat ttccgtgtaa ctgctattga ttcaagagac   600
caaactattg aagcgattga gtctatcgac gagcaccgca ttatcggttt acagtggcat   660
ccagagtttc tggttaatga agaagatggc aatttagaat tatttgagta tttattgaat   720
gaactg                                                              726

<210>   4320
<211>   242
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glutamine amidotransferase, class-I
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903925 (e-137)

<400>   4320
Met Ile Gly Leu Ser Leu Ala Phe Glu Arg Arg Gly Ile Met Ala Arg 
1               5                   10                  15      

Thr Val Val Gly Val Ala Ala Asn Leu Cys Pro Val Asp Ala Glu Gly 
            20                  25                  30          

Lys Ile Ile His Ser Ser Val Ser Cys Arg Phe Ala Glu Ile Ile Arg 
        35                  40                  45              

Gln Val Gly Gly Leu Pro Leu Val Ile Pro Val Gly Asp Glu Ser Val 
    50                  55                  60                  

Val Arg Asp Tyr Val Glu Met Ile Asp Lys Leu Ile Leu Thr Gly Gly 
65                  70                  75                  80  

Gln Asn Val His Pro Gln Phe Tyr Gly Glu Lys Lys Thr Val Glu Ser 
                85                  90                  95      

Asp Asp Tyr Asn Leu Val Arg Asp Glu Phe Glu Leu Ala Leu Leu Lys 
            100                 105                 110         

Glu Ala Leu Arg Gln Asn Lys Pro Ile Met Ala Ile Cys Arg Gly Val 
        115                 120                 125             

Gln Leu Val Asn Val Ala Phe Gly Gly Thr Leu Asn Gln Glu Ile Glu 
    130                 135                 140                 

Gly His Trp Gln Gly Leu Pro Phe Gly Thr Ser His Ser Ile Glu Thr 
145                 150                 155                 160 

Val Glu Gly Ser Val Val Ala Lys Leu Phe Gly Lys Glu Ser Gln Val 
                165                 170                 175     

Asn Ser Val His Arg Gln Ser Ile Lys Asp Leu Ala Pro Asn Phe Arg 
            180                 185                 190         

Val Thr Ala Ile Asp Ser Arg Asp Gln Thr Ile Glu Ala Ile Glu Ser 
        195                 200                 205             

Ile Asp Glu His Arg Ile Ile Gly Leu Gln Trp His Pro Glu Phe Leu 
    210                 215                 220                 

Val Asn Glu Glu Asp Gly Asn Leu Glu Leu Phe Glu Tyr Leu Leu Asn 
225                 230                 235                 240 

Glu Leu 
        

<210>   4321
<211>   1809
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4321
ttggcagtag ctaactgcgc taaatataat ataaggagga gtaaaatgaa gacagttcaa   60
tttttttggc attattttaa ggtctacaag ttctcatttg tagttgtcat cctgatgatt   120
gttctggcga cttttgccca agccctcttt ccagtctttt ctggacaagc ggtgacgcag   180
ctagccaatt tagttcaagc ttatcaaaat ggcaatccag aacttgtatg gcaaagccta   240
tcaggaatca tggtcaatct tggcctgctg gttttggttc tatttatctc tagtgtaata   300
tacatgtgtc tcatgacgcg cgtgattgca gaatcgacca acgagatgcg caaaggcctc   360
tttggtaagc ttgctcagtt gacggtttct ttctttgacc gtcgacaaga tggcgatatc   420
ctgtctcatt ttaccagtga tttggataat atcctccaag cctttaacga aagcttgatt   480
caggtcatga gcaatattgt tttatacatt ggtctgattc ttgtcatgtt ttcgagaaat   540
gtgacgctgg ctctcatcac cattgccagc accccattgg ctttccttat gctgattttc   600
atcgtgaaaa tggcacgcaa atacaccaac ctccagcaga aagaggtagg gaagctcaac   660
gcctatatgg atgagagcat ctcaggccaa aaagccgtga ttgtgcaagg aattcaagag   720
gatatgatgg caggatttct tgaacaaaat gagcgcgtgc gcaaggcaac ctttaaagga   780
agaatgttct caggaattct tttccctgtc atgaatggga tgagcctgat taatacagcc   840
atcgtcatct ttgctggttc ggctgtactt ttgaatgata agtctattga aacaagtaca   900
gccctaggtt tgattgttat gtttgcacaa ttttcacagc agtactacca gcctattatc   960
caagttgcag cgagttgggg aagccttcag ttggccttta ctggagctga acgaattcag   1020
gaaatgtttg atgcagagga ggaaatccga cctgaaaagg ctccaacctt cactaagttg   1080
caagaaagtg ttgaaatcag tcatatcgtt ttttcatact tgcctgataa acctattttg   1140
aaagatgtca gcatttctgc ccctaaaggc cagatgacag cagttgttgg gccgacaggt   1200
tcaggaaaaa cgactattat gaacctcatc aatcgctttt atgatgttga tgctggtggt   1260
atttattttg atggtaaaga cattcgtggc tatgacttag atagtcttag aagcaaggtg   1320
ggaattgtat tgcaagattc ggtcttgttt agcggaacga ttagagacaa tatccgattt   1380
ggtgtgccag atgctagtca ggaaatggtt gaggtagcag caaaagcaac ccacattcac   1440
gactatatcg aaagtttgcc tgataagtac gatactctta ttgatgatga ccagagcatc   1500
ttttcaacag ggcagaagca attgatttca atcgctcgaa ccctgatgac agatccagaa   1560
gttctcattc tcgatgaagc aacttcaaac gtagatacgg tgacagaaag caagattcag   1620
catgccatgg aggtggttgt agcaggtaga actagtttcg tcattgccca ccgcttgaaa   1680
accattctca atgcagatca gattattgtc cttaaagatg gagaagtcat tgaacgtggt   1740
aaccaccatg aacttttgaa gctaggtggc ttttattcag aactctatca caatcaattt   1800
gttttcgaa                                                           1809

<210>   4322
<211>   603
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903926 (0.E+01)

<400>   4322
Met Ala Val Ala Asn Cys Ala Lys Tyr Asn Ile Arg Arg Ser Lys Met 
1               5                   10                  15      

Lys Thr Val Gln Phe Phe Trp His Tyr Phe Lys Val Tyr Lys Phe Ser 
            20                  25                  30          

Phe Val Val Val Ile Leu Met Ile Val Leu Ala Thr Phe Ala Gln Ala 
        35                  40                  45              

Leu Phe Pro Val Phe Ser Gly Gln Ala Val Thr Gln Leu Ala Asn Leu 
    50                  55                  60                  

Val Gln Ala Tyr Gln Asn Gly Asn Pro Glu Leu Val Trp Gln Ser Leu 
65                  70                  75                  80  

Ser Gly Ile Met Val Asn Leu Gly Leu Leu Val Leu Val Leu Phe Ile 
                85                  90                  95      

Ser Ser Val Ile Tyr Met Cys Leu Met Thr Arg Val Ile Ala Glu Ser 
            100                 105                 110         

Thr Asn Glu Met Arg Lys Gly Leu Phe Gly Lys Leu Ala Gln Leu Thr 
        115                 120                 125             

Val Ser Phe Phe Asp Arg Arg Gln Asp Gly Asp Ile Leu Ser His Phe 
    130                 135                 140                 

Thr Ser Asp Leu Asp Asn Ile Leu Gln Ala Phe Asn Glu Ser Leu Ile 
145                 150                 155                 160 

Gln Val Met Ser Asn Ile Val Leu Tyr Ile Gly Leu Ile Leu Val Met 
                165                 170                 175     

Phe Ser Arg Asn Val Thr Leu Ala Leu Ile Thr Ile Ala Ser Thr Pro 
            180                 185                 190         

Leu Ala Phe Leu Met Leu Ile Phe Ile Val Lys Met Ala Arg Lys Tyr 
        195                 200                 205             

Thr Asn Leu Gln Gln Lys Glu Val Gly Lys Leu Asn Ala Tyr Met Asp 
    210                 215                 220                 

Glu Ser Ile Ser Gly Gln Lys Ala Val Ile Val Gln Gly Ile Gln Glu 
225                 230                 235                 240 

Asp Met Met Ala Gly Phe Leu Glu Gln Asn Glu Arg Val Arg Lys Ala 
                245                 250                 255     

Thr Phe Lys Gly Arg Met Phe Ser Gly Ile Leu Phe Pro Val Met Asn 
            260                 265                 270         

Gly Met Ser Leu Ile Asn Thr Ala Ile Val Ile Phe Ala Gly Ser Ala 
        275                 280                 285             

Val Leu Leu Asn Asp Lys Ser Ile Glu Thr Ser Thr Ala Leu Gly Leu 
    290                 295                 300                 

Ile Val Met Phe Ala Gln Phe Ser Gln Gln Tyr Tyr Gln Pro Ile Ile 
305                 310                 315                 320 

Gln Val Ala Ala Ser Trp Gly Ser Leu Gln Leu Ala Phe Thr Gly Ala 
                325                 330                 335     

Glu Arg Ile Gln Glu Met Phe Asp Ala Glu Glu Glu Ile Arg Pro Glu 
            340                 345                 350         

Lys Ala Pro Thr Phe Thr Lys Leu Gln Glu Ser Val Glu Ile Ser His 
        355                 360                 365             

Ile Val Phe Ser Tyr Leu Pro Asp Lys Pro Ile Leu Lys Asp Val Ser 
    370                 375                 380                 

Ile Ser Ala Pro Lys Gly Gln Met Thr Ala Val Val Gly Pro Thr Gly 
385                 390                 395                 400 

Ser Gly Lys Thr Thr Ile Met Asn Leu Ile Asn Arg Phe Tyr Asp Val 
                405                 410                 415     

Asp Ala Gly Gly Ile Tyr Phe Asp Gly Lys Asp Ile Arg Gly Tyr Asp 
            420                 425                 430         

Leu Asp Ser Leu Arg Ser Lys Val Gly Ile Val Leu Gln Asp Ser Val 
        435                 440                 445             

Leu Phe Ser Gly Thr Ile Arg Asp Asn Ile Arg Phe Gly Val Pro Asp 
    450                 455                 460                 

Ala Ser Gln Glu Met Val Glu Val Ala Ala Lys Ala Thr His Ile His 
465                 470                 475                 480 

Asp Tyr Ile Glu Ser Leu Pro Asp Lys Tyr Asp Thr Leu Ile Asp Asp 
                485                 490                 495     

Asp Gln Ser Ile Phe Ser Thr Gly Gln Lys Gln Leu Ile Ser Ile Ala 
            500                 505                 510         

Arg Thr Leu Met Thr Asp Pro Glu Val Leu Ile Leu Asp Glu Ala Thr 
        515                 520                 525             

Ser Asn Val Asp Thr Val Thr Glu Ser Lys Ile Gln His Ala Met Glu 
    530                 535                 540                 

Val Val Val Ala Gly Arg Thr Ser Phe Val Ile Ala His Arg Leu Lys 
545                 550                 555                 560 

Thr Ile Leu Asn Ala Asp Gln Ile Ile Val Leu Lys Asp Gly Glu Val 
                565                 570                 575     

Ile Glu Arg Gly Asn His His Glu Leu Leu Lys Leu Gly Gly Phe Tyr 
            580                 585                 590         

Ser Glu Leu Tyr His Asn Gln Phe Val Phe Glu 
        595                 600             

<210>   4323
<211>   207
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4323
atggctgagt tcaactcggt catcacgacg gttactggga ttggggatcg tttaggggcg   60
gtcattttag ctgagattcg aaatattcat gcctttgata atcctgctca attacaagct   120
ttcgctggac tggattcttc tatttatcag tcagatcaga ttgatttagc aggaagaatg   180
gtcaaacgga gttcccctca tctgcgg                                       207

<210>   4324
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, IS116/IS110/IS902 family, degenerate

<400>   4324
Met Ala Glu Phe Asn Ser Val Ile Thr Thr Val Thr Gly Ile Gly Asp 
1               5                   10                  15      

Arg Leu Gly Ala Val Ile Leu Ala Glu Ile Arg Asn Ile His Ala Phe 
            20                  25                  30          

Asp Asn Pro Ala Gln Leu Gln Ala Phe Ala Gly Leu Asp Ser Ser Ile 
        35                  40                  45              

Tyr Gln Ser Asp Gln Ile Asp Leu Ala Gly Arg Met Val Lys Arg Ser 
    50                  55                  60                  

Ser Pro His Leu Arg 
65                  

<210>   4325
<211>   1638
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4325
atgacaggct tgatggttgc tagttcactt ctgcaaccgc gttatctgca ggaagtctta   60
ggcgccctcc ttactgggaa atatgaagct atttatagta tcggggcttg gttgattggt   120
gtggccgtag tcggtctagt tgctggtgga ctcaatgttg tcctcgcagc ctatattgcc   180
caaggagttt catccgacct tcgggaggat gccttccgta aaattcaaac cttttcttat   240
gctgatattg aacaatttaa tgcgggaaat ctagtcgttc gaatgacaaa tgatatcaac   300
cagattcaga acgttgtcat gatgaccttc caaattcttt tcagacttcc cctcttgttc   360
atcggttcgt ttatcctagc ggttcaaacc ttaccttctc tgtggtgggt gattgttctc   420
atggtagtct tgatttttgg tttgactgct gtcatgatgg gaatgatggg gcctcgtttt   480
gccaagtttc aaacccttct tgagcgcatc aatgccattg ccaaggaaaa tttacgtggc   540
gttcgtgtgg tcaagtcctt tgtccaagaa aaagagcaat ttgctaagtt tacagaggtc   600
tcagacgagc ttcttggtca aaacctttac attggttatg ccttttcagt agtggaaccc   660
tttatgatgt tggttggtta cggggcggtc ttcctctcta tttggctggt cgcgggaatg   720
gttcagtcgg atccgtctgt tgttggttcc atcgcttctt ttgttaatta cctaagccag   780
attatcttta ccattgttat ggttggattt ttgggaaatt ctgtcagccg tgccatgatt   840
tccatgcgtc gtattcgaga aattcttgac gcagagccag ctatgacctt caaggatatc   900
ccagatgaag agttggttgg aagtcttagc tttgaaaatg tgacctttac ctatccaatg   960
gacaaggaac cgatgctgaa agatgtgagc tttactattg aacctggtca aatggttggt   1020
gtagttggag cgactggtgc aggaaagtca accttggctc aattgattcc acgtctcttt   1080
gatccacagg acggggccat taaaatcggt ggcaaggata ttcgagaagt gagtgaagga   1140
accctgcgta aaacagtttc catcgttctc caacgtgcca ttctttttag tggaacgatt   1200
gcagataact tgagacaggg gaaggggaat gctactctat ttgaaatgga gcgcgcagcc   1260
aatattgccc aggctagtga attcattcat cgtatggaga aaacctttga aagtccagtt   1320
gaagaacggg gaaccaattt ctctggtgga caaaaacaaa ggatgtcgat tgcgcgtggg   1380
attgtcagca atccacgtat tctgattttt gatgattcga cctcagcctt ggatgccaaa   1440
tcagagcgct tggtgcaaga agctttgaat aaggacttga aggggacgac aaccattatt   1500
attgctcaaa aaattagctc ggttgtccat gcagacaaga tcttggttct aaatcaagga   1560
cgattgattg gtcaaggtac gcatgcagac ttggttgcca acaatgccgt ttaccgtgaa   1620
atctatgaaa cacagaaa                                                 1638

<210>   4326
<211>   546
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding/permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903928 (0.E+01)

<400>   4326
Met Thr Gly Leu Met Val Ala Ser Ser Leu Leu Gln Pro Arg Tyr Leu 
1               5                   10                  15      

Gln Glu Val Leu Gly Ala Leu Leu Thr Gly Lys Tyr Glu Ala Ile Tyr 
            20                  25                  30          

Ser Ile Gly Ala Trp Leu Ile Gly Val Ala Val Val Gly Leu Val Ala 
        35                  40                  45              

Gly Gly Leu Asn Val Val Leu Ala Ala Tyr Ile Ala Gln Gly Val Ser 
    50                  55                  60                  

Ser Asp Leu Arg Glu Asp Ala Phe Arg Lys Ile Gln Thr Phe Ser Tyr 
65                  70                  75                  80  

Ala Asp Ile Glu Gln Phe Asn Ala Gly Asn Leu Val Val Arg Met Thr 
                85                  90                  95      

Asn Asp Ile Asn Gln Ile Gln Asn Val Val Met Met Thr Phe Gln Ile 
            100                 105                 110         

Leu Phe Arg Leu Pro Leu Leu Phe Ile Gly Ser Phe Ile Leu Ala Val 
        115                 120                 125             

Gln Thr Leu Pro Ser Leu Trp Trp Val Ile Val Leu Met Val Val Leu 
    130                 135                 140                 

Ile Phe Gly Leu Thr Ala Val Met Met Gly Met Met Gly Pro Arg Phe 
145                 150                 155                 160 

Ala Lys Phe Gln Thr Leu Leu Glu Arg Ile Asn Ala Ile Ala Lys Glu 
                165                 170                 175     

Asn Leu Arg Gly Val Arg Val Val Lys Ser Phe Val Gln Glu Lys Glu 
            180                 185                 190         

Gln Phe Ala Lys Phe Thr Glu Val Ser Asp Glu Leu Leu Gly Gln Asn 
        195                 200                 205             

Leu Tyr Ile Gly Tyr Ala Phe Ser Val Val Glu Pro Phe Met Met Leu 
    210                 215                 220                 

Val Gly Tyr Gly Ala Val Phe Leu Ser Ile Trp Leu Val Ala Gly Met 
225                 230                 235                 240 

Val Gln Ser Asp Pro Ser Val Val Gly Ser Ile Ala Ser Phe Val Asn 
                245                 250                 255     

Tyr Leu Ser Gln Ile Ile Phe Thr Ile Val Met Val Gly Phe Leu Gly 
            260                 265                 270         

Asn Ser Val Ser Arg Ala Met Ile Ser Met Arg Arg Ile Arg Glu Ile 
        275                 280                 285             

Leu Asp Ala Glu Pro Ala Met Thr Phe Lys Asp Ile Pro Asp Glu Glu 
    290                 295                 300                 

Leu Val Gly Ser Leu Ser Phe Glu Asn Val Thr Phe Thr Tyr Pro Met 
305                 310                 315                 320 

Asp Lys Glu Pro Met Leu Lys Asp Val Ser Phe Thr Ile Glu Pro Gly 
                325                 330                 335     

Gln Met Val Gly Val Val Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu 
            340                 345                 350         

Ala Gln Leu Ile Pro Arg Leu Phe Asp Pro Gln Asp Gly Ala Ile Lys 
        355                 360                 365             

Ile Gly Gly Lys Asp Ile Arg Glu Val Ser Glu Gly Thr Leu Arg Lys 
    370                 375                 380                 

Thr Val Ser Ile Val Leu Gln Arg Ala Ile Leu Phe Ser Gly Thr Ile 
385                 390                 395                 400 

Ala Asp Asn Leu Arg Gln Gly Lys Gly Asn Ala Thr Leu Phe Glu Met 
                405                 410                 415     

Glu Arg Ala Ala Asn Ile Ala Gln Ala Ser Glu Phe Ile His Arg Met 
            420                 425                 430         

Glu Lys Thr Phe Glu Ser Pro Val Glu Glu Arg Gly Thr Asn Phe Ser 
        435                 440                 445             

Gly Gly Gln Lys Gln Arg Met Ser Ile Ala Arg Gly Ile Val Ser Asn 
    450                 455                 460                 

Pro Arg Ile Leu Ile Phe Asp Asp Ser Thr Ser Ala Leu Asp Ala Lys 
465                 470                 475                 480 

Ser Glu Arg Leu Val Gln Glu Ala Leu Asn Lys Asp Leu Lys Gly Thr 
                485                 490                 495     

Thr Thr Ile Ile Ile Ala Gln Lys Ile Ser Ser Val Val His Ala Asp 
            500                 505                 510         

Lys Ile Leu Val Leu Asn Gln Gly Arg Leu Ile Gly Gln Gly Thr His 
        515                 520                 525             

Ala Asp Leu Val Ala Asn Asn Ala Val Tyr Arg Glu Ile Tyr Glu Thr 
    530                 535                 540                 

Gln Lys 
545     

<210>   4327
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4327
ttgtcgctcc cttttgtcta ttttttaagg agaaagtatg ctgattcaga aaataaaaac   60
ctacaagtgg caggccctgg cttcgctcct gatgacaggc ttgatggttg c            111

<210>   4328
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein FRAMESHIFT

<400>   4328
Met Ser Leu Pro Phe Val Tyr Phe Leu Arg Arg Lys Tyr Ala Asp Ser 
1               5                   10                  15      

Glu Asn Lys Asn Leu Gln Val Ala Gly Pro Gly Phe Ala Pro Asp Asp 
            20                  25                  30          

Arg Leu Asp Gly Cys 
        35          

<210>   4329
<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4329
ttgccagcag accttttagc aagggcggat aagattttga ctcagctaga gaatcaagga   60
acagagagtc ctcctcccat gagacaaact agtgctgtca ctgaacagat ttcactcttt   120
gatagggcag aagagcatcc tatcctagca gaattagcta aactggatgt gtataatatg   180
acacctatgc aggttatgaa tgtcttagta gagttaaaac agaaacta                228

<210>   4330
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA mismatch repair protein hexa-related

<400>   4330
Met Pro Ala Asp Leu Leu Ala Arg Ala Asp Lys Ile Leu Thr Gln Leu 
1               5                   10                  15      

Glu Asn Gln Gly Thr Glu Ser Pro Pro Pro Met Arg Gln Thr Ser Ala 
            20                  25                  30          

Val Thr Glu Gln Ile Ser Leu Phe Asp Arg Ala Glu Glu His Pro Ile 
        35                  40                  45              

Leu Ala Glu Leu Ala Lys Leu Asp Val Tyr Asn Met Thr Pro Met Gln 
    50                  55                  60                  

Val Met Asn Val Leu Val Glu Leu Lys Gln Lys Leu 
65                  70                  75      

<210>   4331
<211>   2358
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4331
ttgctctcaa gacttatttt tgaaaaggag agacagaaaa tggcgataga aaagttatca   60
cccggcatgc aacagtatgt ggatattaaa aagcaatatc cagatgcttt tttgctcttt   120
cggatgggtg atttttatga attattttat gaggatgcgg tcaatgctgc gcagattctg   180
gaaatttcct taacgagtcg caacaagaat gccgacaatc cgatccctat ggcgggtgtt   240
ccctatcatt ctgcccaaca gtatatcgat gtcttgattg agcagggtta taaggtggct   300
atcgcagagc agatggaaga tcctaaacaa gcagttgggg ttgttaaacg agaggttgtt   360
caggtcatta cgccagggac agtggtcgat agcagtaagc cggacagtca gaataatttt   420
ttggtttcca tagaccgcga aggcaatcaa tttggcctag cttatatgga tttggtgacg   480
ggtgactttt atgtgacagg tcttttggat ttcacgctgg tttgtgggga aatccgtaac   540
ctcaaggctc gagaagtggt gttgggttat gacttgtctg aggaagaaga acaaatcctc   600
agccgccaga tgaatctggt actctcttat gaaaaagaaa gctttgaaga ccttcattta   660
ttggatttgc gattggcaac ggtggagcaa acggcatcta gtaagctgct ccagtatgtt   720
catcggactc agatgaggga attgaaccac ctcaaacctg ttatccgcta cgaaattaag   780
gatttcttgc agatggatta tgcgaccaag gctagtctgg atttggttga gaatgctcgc   840
tcaggtaaga aacaaggcag tcttttctgg cttttggatg aaaccaaaac ggctatgggg   900
atgcgtctct tgcgttcttg gattcatcgc cccttgattg ataaggaacg aatcgtccaa   960
cgtcaagaag tagtgcaggt ctttctcgac catttctttg agcgtagtga cttgacagac   1020
agtctcaagg gtgtttatga cattgagcgc ttggctagtc gtgtttcttt tggcaaaacc   1080
aatccaaagg atctcttgca gttggcgact accttgtcta gtgtgccacg gattcgtgcg   1140
attttagaag ggatggagca acctactcta gcctatctca tcgcacaact ggatgcaatc   1200
cctgagttgg agagtttgat tagcgcagcg attgctcctg aagctcctca tgtgattaca   1260
gatgggggaa ttatccggac tggatttgat gagactttag acaagtatcg ttgcgttctc   1320
agagaaggga ctagctggat tgctgagatt gaggctaagg agcgagaaaa ctctggtatc   1380
agcacgctca agattgacta caataaaaag gatggctact attttcatgt gaccaattcg   1440
caactaggaa atgtgccagc tcactttttc cgcaaggcga cgctgaaaaa ctcagaacgc   1500
tttggaaccg aagaattagc ccgtatcgag ggagatatgc ttgaggcgcg tgagaagtca   1560
gccaacctcg aatacgaaat atttatgcgc attcgtgaag aggtcggcaa gtacatccag   1620
cgtttacaag ctctagccca aggaattgcg acggttgatg tcttacagag tctggcggtt   1680
gtggctgaaa cccagcattt gattcgacct gagtttggtg acgattcaca aattgatatc   1740
cggaaagggc gccatgctgt cgttgaaaag gttatggggg ctcagaccta tattccaaat   1800
acgattcaga tggcagaaga taccagtatt caactggtta cagggccaaa catgagtggg   1860
aagtctacct atatgcgtca gttagccatg acggcggtta tggcccagct gggttcctat   1920
gttcctgctg aaagcgccca tttaccgatt tttgatgcga tttttacccg tatcggagca   1980
gcagatgact tggtttcggg tcagtcaacc tttatggtgg agatgatgga ggccaataat   2040
gccatttcgc atgcgaccaa gaactctctc attctctttg atgaattggg acgtggaact   2100
gcaacttatg acgggatggc tcttgctcag tccatcatcg aatatatcca tgagcacatc   2160
ggagctaaga ccctctttgc gacccactac catgagttga ctagtctgga gtctagttta   2220
caacacttgg tcaatgtcca cgtggcaact ttggagcagg atgggcaggt caccttcctt   2280
cacaagattg aaccgggacc agctgataaa tctacggtat ccatgttgcc aagattgctg   2340
gcttgccagc agaccttt                                                 2358

<210>   4332
<211>   786
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA mismatch repair protein HexA, FRAMESHIFT

<400>   4332
Met Leu Ser Arg Leu Ile Phe Glu Lys Glu Arg Gln Lys Met Ala Ile 
1               5                   10                  15      

Glu Lys Leu Ser Pro Gly Met Gln Gln Tyr Val Asp Ile Lys Lys Gln 
            20                  25                  30          

Tyr Pro Asp Ala Phe Leu Leu Phe Arg Met Gly Asp Phe Tyr Glu Leu 
        35                  40                  45              

Phe Tyr Glu Asp Ala Val Asn Ala Ala Gln Ile Leu Glu Ile Ser Leu 
    50                  55                  60                  

Thr Ser Arg Asn Lys Asn Ala Asp Asn Pro Ile Pro Met Ala Gly Val 
65                  70                  75                  80  

Pro Tyr His Ser Ala Gln Gln Tyr Ile Asp Val Leu Ile Glu Gln Gly 
                85                  90                  95      

Tyr Lys Val Ala Ile Ala Glu Gln Met Glu Asp Pro Lys Gln Ala Val 
            100                 105                 110         

Gly Val Val Lys Arg Glu Val Val Gln Val Ile Thr Pro Gly Thr Val 
        115                 120                 125             

Val Asp Ser Ser Lys Pro Asp Ser Gln Asn Asn Phe Leu Val Ser Ile 
    130                 135                 140                 

Asp Arg Glu Gly Asn Gln Phe Gly Leu Ala Tyr Met Asp Leu Val Thr 
145                 150                 155                 160 

Gly Asp Phe Tyr Val Thr Gly Leu Leu Asp Phe Thr Leu Val Cys Gly 
                165                 170                 175     

Glu Ile Arg Asn Leu Lys Ala Arg Glu Val Val Leu Gly Tyr Asp Leu 
            180                 185                 190         

Ser Glu Glu Glu Glu Gln Ile Leu Ser Arg Gln Met Asn Leu Val Leu 
        195                 200                 205             

Ser Tyr Glu Lys Glu Ser Phe Glu Asp Leu His Leu Leu Asp Leu Arg 
    210                 215                 220                 

Leu Ala Thr Val Glu Gln Thr Ala Ser Ser Lys Leu Leu Gln Tyr Val 
225                 230                 235                 240 

His Arg Thr Gln Met Arg Glu Leu Asn His Leu Lys Pro Val Ile Arg 
                245                 250                 255     

Tyr Glu Ile Lys Asp Phe Leu Gln Met Asp Tyr Ala Thr Lys Ala Ser 
            260                 265                 270         

Leu Asp Leu Val Glu Asn Ala Arg Ser Gly Lys Lys Gln Gly Ser Leu 
        275                 280                 285             

Phe Trp Leu Leu Asp Glu Thr Lys Thr Ala Met Gly Met Arg Leu Leu 
    290                 295                 300                 

Arg Ser Trp Ile His Arg Pro Leu Ile Asp Lys Glu Arg Ile Val Gln 
305                 310                 315                 320 

Arg Gln Glu Val Val Gln Val Phe Leu Asp His Phe Phe Glu Arg Ser 
                325                 330                 335     

Asp Leu Thr Asp Ser Leu Lys Gly Val Tyr Asp Ile Glu Arg Leu Ala 
            340                 345                 350         

Ser Arg Val Ser Phe Gly Lys Thr Asn Pro Lys Asp Leu Leu Gln Leu 
        355                 360                 365             

Ala Thr Thr Leu Ser Ser Val Pro Arg Ile Arg Ala Ile Leu Glu Gly 
    370                 375                 380                 

Met Glu Gln Pro Thr Leu Ala Tyr Leu Ile Ala Gln Leu Asp Ala Ile 
385                 390                 395                 400 

Pro Glu Leu Glu Ser Leu Ile Ser Ala Ala Ile Ala Pro Glu Ala Pro 
                405                 410                 415     

His Val Ile Thr Asp Gly Gly Ile Ile Arg Thr Gly Phe Asp Glu Thr 
            420                 425                 430         

Leu Asp Lys Tyr Arg Cys Val Leu Arg Glu Gly Thr Ser Trp Ile Ala 
        435                 440                 445             

Glu Ile Glu Ala Lys Glu Arg Glu Asn Ser Gly Ile Ser Thr Leu Lys 
    450                 455                 460                 

Ile Asp Tyr Asn Lys Lys Asp Gly Tyr Tyr Phe His Val Thr Asn Ser 
465                 470                 475                 480 

Gln Leu Gly Asn Val Pro Ala His Phe Phe Arg Lys Ala Thr Leu Lys 
                485                 490                 495     

Asn Ser Glu Arg Phe Gly Thr Glu Glu Leu Ala Arg Ile Glu Gly Asp 
            500                 505                 510         

Met Leu Glu Ala Arg Glu Lys Ser Ala Asn Leu Glu Tyr Glu Ile Phe 
        515                 520                 525             

Met Arg Ile Arg Glu Glu Val Gly Lys Tyr Ile Gln Arg Leu Gln Ala 
    530                 535                 540                 

Leu Ala Gln Gly Ile Ala Thr Val Asp Val Leu Gln Ser Leu Ala Val 
545                 550                 555                 560 

Val Ala Glu Thr Gln His Leu Ile Arg Pro Glu Phe Gly Asp Asp Ser 
                565                 570                 575     

Gln Ile Asp Ile Arg Lys Gly Arg His Ala Val Val Glu Lys Val Met 
            580                 585                 590         

Gly Ala Gln Thr Tyr Ile Pro Asn Thr Ile Gln Met Ala Glu Asp Thr 
        595                 600                 605             

Ser Ile Gln Leu Val Thr Gly Pro Asn Met Ser Gly Lys Ser Thr Tyr 
    610                 615                 620                 

Met Arg Gln Leu Ala Met Thr Ala Val Met Ala Gln Leu Gly Ser Tyr 
625                 630                 635                 640 

Val Pro Ala Glu Ser Ala His Leu Pro Ile Phe Asp Ala Ile Phe Thr 
                645                 650                 655     

Arg Ile Gly Ala Ala Asp Asp Leu Val Ser Gly Gln Ser Thr Phe Met 
            660                 665                 670         

Val Glu Met Met Glu Ala Asn Asn Ala Ile Ser His Ala Thr Lys Asn 
        675                 680                 685             

Ser Leu Ile Leu Phe Asp Glu Leu Gly Arg Gly Thr Ala Thr Tyr Asp 
    690                 695                 700                 

Gly Met Ala Leu Ala Gln Ser Ile Ile Glu Tyr Ile His Glu His Ile 
705                 710                 715                 720 

Gly Ala Lys Thr Leu Phe Ala Thr His Tyr His Glu Leu Thr Ser Leu 
                725                 730                 735     

Glu Ser Ser Leu Gln His Leu Val Asn Val His Val Ala Thr Leu Glu 
            740                 745                 750         

Gln Asp Gly Gln Val Thr Phe Leu His Lys Ile Glu Pro Gly Pro Ala 
        755                 760                 765             

Asp Lys Ser Thr Val Ser Met Leu Pro Arg Leu Leu Ala Cys Gln Gln 
    770                 775                 780                 

Thr Phe 
785     

<210>   4333
<211>   444
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4333
atgagaaaaa gagatcgtca tcagttaata aaaaaaatga ttactgagga gaaattaagt   60
acacaaaaag aaattcaaga tcggttggag gcgcacaatg tttgtgtgac gcagacaacc   120
ttgtctcgtg atttgcgcga aatcggcttg accaaggtca agaaaaatga tatggtgtat   180
tatgtactag taaatgagac agaaaagatt gatttggtgg aatttttgtc tcatcattta   240
gaaggtgttg caagagcaga gtttaccttg gtgcttcata ccaaattggg agaagcctct   300
gttttggcaa atattgtaga tgtaaacaag gatgaatgga ttttaggaac agttgctggt   360
gccaatacct tattggttat ttgtcgagat cagcacgttg ccaaactcat ggaagatcgt   420
ttgctagatt tgatgaaaga taag                                          444

<210>   4334
<211>   148
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional repressor, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903930 (1.E-80)

<400>   4334
Met Arg Lys Arg Asp Arg His Gln Leu Ile Lys Lys Met Ile Thr Glu 
1               5                   10                  15      

Glu Lys Leu Ser Thr Gln Lys Glu Ile Gln Asp Arg Leu Glu Ala His 
            20                  25                  30          


Asn Val Cys Val Thr Gln Thr Thr Leu Ser Arg Asp Leu Arg Glu Ile 
        35                  40                  45              

Gly Leu Thr Lys Val Lys Lys Asn Asp Met Val Tyr Tyr Val Leu Val 
    50                  55                  60                  

Asn Glu Thr Glu Lys Ile Asp Leu Val Glu Phe Leu Ser His His Leu 
65                  70                  75                  80  

Glu Gly Val Ala Arg Ala Glu Phe Thr Leu Val Leu His Thr Lys Leu 
                85                  90                  95      

Gly Glu Ala Ser Val Leu Ala Asn Ile Val Asp Val Asn Lys Asp Glu 
            100                 105                 110         

Trp Ile Leu Gly Thr Val Ala Gly Ala Asn Thr Leu Leu Val Ile Cys 
        115                 120                 125             

Arg Asp Gln His Val Ala Lys Leu Met Glu Asp Arg Leu Leu Asp Leu 
    130                 135                 140                 

Met Lys Asp Lys 
145             

<210>   4335
<211>   1689
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4335
atgaatacaa aagaattgat tgctagcgaa ttatctagca tcattgatag cctggaccaa   60
gaggctattt taaagttact ggaaacccct aaaaactcag aaatgggaga cattgctttc   120
cctgcttttt ctcttgcaaa agtcgaacgt aaagcaccac aaatgattgc ggctgaactg   180
gctgaaaaaa tgaacagcca agcctttgaa aaagttgtcg caacaggacc ttacgttaac   240
tttttccttg ataaatctgc catttctgct caagtattgc aagctgttac cactgaaaaa   300
gaacactatg ctgaccaaaa tattggtaaa caagaaaatg ttgttatcga catgtctagt   360
ccgaatatcg ctaaaccatt ttctattggc cacctgcgtt caactgttat cggagatagc   420
ttgtcacata ttttccaaaa aatcggttat caaacggtca aggtcaacca tttgggagac   480
tggggtaaac aatttgggat gttgattgtt gcctacaaaa aatggggcga cgaagaagct   540
gtaaaagctc atccaatcga tgaactcctt aaactctatg tccgcatcaa cgctgaagct   600
gaaaatgacc ctagcttgga tgaagaagcg cgcgaatggt tccgtaaact tgaaaatgga   660
gatgaggaag ctctcgctct ttggcaatgg ttccgcgatg aaagtttagt ggaatttaac   720
cgcctttaca atgaattgaa ggttgaattt gacagctata acggagaagc cttctacaat   780
gataagatgg atgcagttgt agacattctt tctgaaaaag gactacttct tgaatcagaa   840
ggtgcccaag ttgtgaatct tgagaaatat ggaattgaac atccagccct catcaagaag   900
tctgatggtg caactctcta tatcacacgt gacttggctg cagccctcta ccgtaaaaac   960
gaataccaat ttgctaaatc tatctatgtc gttggtcaag aacaatctgc ccactttaaa   1020
cagctcaaag ctgtcttgca agagatgggc tacgactgga gtgacgacat tactcacgtt   1080
ccttttggtt tggttacaaa agaagggaag aaactctcta ctcgtaaagg gaatgtcatc   1140
ttgctagagc ctactgttgc agaggctgtt agccgtgcca aggtccaaat cgaggctaaa   1200
aatcctgaac tagaaaacaa agaccaagta gcacatgctg ttgggattgg agccattaaa   1260
ttctatgacc tcaaaaccga ccgtacaaat ggatacgact tcgacctaga ggctatggta   1320
tccttcgagg gtgaaactgg accttacgtt caatatgcct acgctcgtat ccaatctatc   1380
ttacgcaaag ccgatttcaa accagaaaca gctggcaact atagcttgaa tgatactgaa   1440
agctgggaaa tcattaaact cattcaagac ttcccacgta ttatcaaccg tgcggcagat   1500
aactttgaac cttctatcat tgctaaattt gcaattagcc tggctcaatc ctttaacaaa   1560
tactatgcac atacacgtat cttggatgaa agcccagaac gcgacagccg tctagccctc   1620
agctacgcaa ccgcagtcgt tctcaaagaa gcccttcgct tgcttggagt agaagcgcca   1680
gagaagatg                                                           1689

<210>   4336
<211>   563
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   arginyl-tRNA synthetase (argS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903931 (0.E+01)

<400>   4336
Met Asn Thr Lys Glu Leu Ile Ala Ser Glu Leu Ser Ser Ile Ile Asp 
1               5                   10                  15      

Ser Leu Asp Gln Glu Ala Ile Leu Lys Leu Leu Glu Thr Pro Lys Asn 
            20                  25                  30          

Ser Glu Met Gly Asp Ile Ala Phe Pro Ala Phe Ser Leu Ala Lys Val 
        35                  40                  45              

Glu Arg Lys Ala Pro Gln Met Ile Ala Ala Glu Leu Ala Glu Lys Met 
    50                  55                  60                  

Asn Ser Gln Ala Phe Glu Lys Val Val Ala Thr Gly Pro Tyr Val Asn 
65                  70                  75                  80  

Phe Phe Leu Asp Lys Ser Ala Ile Ser Ala Gln Val Leu Gln Ala Val 
                85                  90                  95      

Thr Thr Glu Lys Glu His Tyr Ala Asp Gln Asn Ile Gly Lys Gln Glu 
            100                 105                 110         

Asn Val Val Ile Asp Met Ser Ser Pro Asn Ile Ala Lys Pro Phe Ser 
        115                 120                 125             

Ile Gly His Leu Arg Ser Thr Val Ile Gly Asp Ser Leu Ser His Ile 
    130                 135                 140                 

Phe Gln Lys Ile Gly Tyr Gln Thr Val Lys Val Asn His Leu Gly Asp 
145                 150                 155                 160 

Trp Gly Lys Gln Phe Gly Met Leu Ile Val Ala Tyr Lys Lys Trp Gly 
                165                 170                 175     

Asp Glu Glu Ala Val Lys Ala His Pro Ile Asp Glu Leu Leu Lys Leu 
            180                 185                 190         

Tyr Val Arg Ile Asn Ala Glu Ala Glu Asn Asp Pro Ser Leu Asp Glu 
        195                 200                 205             

Glu Ala Arg Glu Trp Phe Arg Lys Leu Glu Asn Gly Asp Glu Glu Ala 
    210                 215                 220                 

Leu Ala Leu Trp Gln Trp Phe Arg Asp Glu Ser Leu Val Glu Phe Asn 
225                 230                 235                 240 

Arg Leu Tyr Asn Glu Leu Lys Val Glu Phe Asp Ser Tyr Asn Gly Glu 
                245                 250                 255     

Ala Phe Tyr Asn Asp Lys Met Asp Ala Val Val Asp Ile Leu Ser Glu 
            260                 265                 270         

Lys Gly Leu Leu Leu Glu Ser Glu Gly Ala Gln Val Val Asn Leu Glu 
        275                 280                 285             

Lys Tyr Gly Ile Glu His Pro Ala Leu Ile Lys Lys Ser Asp Gly Ala 
    290                 295                 300                 

Thr Leu Tyr Ile Thr Arg Asp Leu Ala Ala Ala Leu Tyr Arg Lys Asn 
305                 310                 315                 320 

Glu Tyr Gln Phe Ala Lys Ser Ile Tyr Val Val Gly Gln Glu Gln Ser 
                325                 330                 335     

Ala His Phe Lys Gln Leu Lys Ala Val Leu Gln Glu Met Gly Tyr Asp 
            340                 345                 350         

Trp Ser Asp Asp Ile Thr His Val Pro Phe Gly Leu Val Thr Lys Glu 
        355                 360                 365             

Gly Lys Lys Leu Ser Thr Arg Lys Gly Asn Val Ile Leu Leu Glu Pro 
    370                 375                 380                 

Thr Val Ala Glu Ala Val Ser Arg Ala Lys Val Gln Ile Glu Ala Lys 
385                 390                 395                 400 

Asn Pro Glu Leu Glu Asn Lys Asp Gln Val Ala His Ala Val Gly Ile 
                405                 410                 415     

Gly Ala Ile Lys Phe Tyr Asp Leu Lys Thr Asp Arg Thr Asn Gly Tyr 
            420                 425                 430         

Asp Phe Asp Leu Glu Ala Met Val Ser Phe Glu Gly Glu Thr Gly Pro 
        435                 440                 445             

Tyr Val Gln Tyr Ala Tyr Ala Arg Ile Gln Ser Ile Leu Arg Lys Ala 
    450                 455                 460                 

Asp Phe Lys Pro Glu Thr Ala Gly Asn Tyr Ser Leu Asn Asp Thr Glu 
465                 470                 475                 480 

Ser Trp Glu Ile Ile Lys Leu Ile Gln Asp Phe Pro Arg Ile Ile Asn 
                485                 490                 495     

Arg Ala Ala Asp Asn Phe Glu Pro Ser Ile Ile Ala Lys Phe Ala Ile 
            500                 505                 510         

Ser Leu Ala Gln Ser Phe Asn Lys Tyr Tyr Ala His Thr Arg Ile Leu 
        515                 520                 525             

Asp Glu Ser Pro Glu Arg Asp Ser Arg Leu Ala Leu Ser Tyr Ala Thr 
    530                 535                 540                 

Ala Val Val Leu Lys Glu Ala Leu Arg Leu Leu Gly Val Glu Ala Pro 
545                 550                 555                 560 

Glu Lys Met 
            

<210>   4337
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4337
atgaaggctc aagcgattgt cacaagtcaa gggagaattg tttctttgga tatcgctgtg   60
aactattgtc atgatatgaa gttgttcaaa atgagtcgca gaaatatcgg acaagctggt   120
aaaatcttgg ctgacagtgg ttatcaaggg ctcatgaaga tatatcctca agcacaaact   180
ccacgtaaat ccagcaaact caagccacta acagttgaag ataaagccta taaccatgcg   240
ctatccaagg agagaagcaa ggttgagaac atctttgcca aagtaaaaac gtttaaaatg   300
atttcaacaa cctatcgaaa tcatcgtaaa cacttcggat tacgaatgaa tttgattgct   360
ggcattatca atcatgaact aggattc                                       387

<210>   4338
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfB FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903615 (2.E-66)

<400>   4338
Met Lys Ala Gln Ala Ile Val Thr Ser Gln Gly Arg Ile Val Ser Leu 
1               5                   10                  15      

Asp Ile Ala Val Asn Tyr Cys His Asp Met Lys Leu Phe Lys Met Ser 
            20                  25                  30          

Arg Arg Asn Ile Gly Gln Ala Gly Lys Ile Leu Ala Asp Ser Gly Tyr 
        35                  40                  45              

Gln Gly Leu Met Lys Ile Tyr Pro Gln Ala Gln Thr Pro Arg Lys Ser 
    50                  55                  60                  

Ser Lys Leu Lys Pro Leu Thr Val Glu Asp Lys Ala Tyr Asn His Ala 
65                  70                  75                  80  

Leu Ser Lys Glu Arg Ser Lys Val Glu Asn Ile Phe Ala Lys Val Lys 
                85                  90                  95      

Thr Phe Lys Met Ile Ser Thr Thr Tyr Arg Asn His Arg Lys His Phe 
            100                 105                 110         

Gly Leu Arg Met Asn Leu Ile Ala Gly Ile Ile Asn His Glu Leu Gly 
        115                 120                 125             

Phe 
    

<210>   4339
<211>   459
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4339
ttgataagaa ctctagagtt agctccccat attgaaggtg gctattttag acaaacaaaa   60
aaagcttcag acactataaa ccttgctggt aagggaaggg cgctttatac cagtatttat   120
ttcttattag aagaaacgaa tccttcacat tttcaccgat tgacagcaga tgaaatctgg   180
tattttcatg caggatcccc acttactgtt cacatgatta cagcagatgg tcactacgaa   240
gcagtcactt taggcctgga catatccaaa gggcaacaac ttcactactg tgttcctaag   300
ggcactattt ggggatcaac agttgataag gatgatgctc tggtttcttg tcttgttgct   360
cctggttttg aatttgagga ttttgaatta tttgaaaggg tagatctact ggcgacctat   420
ccagagcaca aggagatgat tgagcgtttg accagatac                          459

<210>   4340
<211>   153
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (Tranposase)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902886 (3.E-20)

<400>   4340
Met Ile Arg Thr Leu Glu Leu Ala Pro His Ile Glu Gly Gly Tyr Phe 
1               5                   10                  15      

Arg Gln Thr Lys Lys Ala Ser Asp Thr Ile Asn Leu Ala Gly Lys Gly 
            20                  25                  30          

Arg Ala Leu Tyr Thr Ser Ile Tyr Phe Leu Leu Glu Glu Thr Asn Pro 
        35                  40                  45              

Ser His Phe His Arg Leu Thr Ala Asp Glu Ile Trp Tyr Phe His Ala 
    50                  55                  60                  

Gly Ser Pro Leu Thr Val His Met Ile Thr Ala Asp Gly His Tyr Glu 
65                  70                  75                  80  

Ala Val Thr Leu Gly Leu Asp Ile Ser Lys Gly Gln Gln Leu His Tyr 
                85                  90                  95      

Cys Val Pro Lys Gly Thr Ile Trp Gly Ser Thr Val Asp Lys Asp Asp 
            100                 105                 110         

Ala Leu Val Ser Cys Leu Val Ala Pro Gly Phe Glu Phe Glu Asp Phe 
        115                 120                 125             

Glu Leu Phe Glu Arg Val Asp Leu Leu Ala Thr Tyr Pro Glu His Lys 
    130                 135                 140                 

Glu Met Ile Glu Arg Leu Thr Arg Tyr 
145                 150             

<210>   4341
<211>   705
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4341
atgacaaaac aagtcttatt agtggatgat gaagaacaca ttctgaaatt gcttgactac   60
catttaagta aggaaggctt ttctactcaa ttggtgacaa atggacggaa ggccttagct   120
ttggcagaaa cagaaccctt tgattttatc ttgcttgata tcatgttacc acaattagat   180
ggcatggaag tttgtaagcg gctgagagcc aaaggcgtca aaactccaat tatgatggtt   240
tctgcgaaaa gtgatgaatt tgataaggtt ttggccttgg aattaggggc tgatgactac   300
ctgaccaagc cttttagccc tagagaattg ctggcgcgtg tcaaggctgt cctcaggcga   360
actaaaggag aacaagaagg agatgattca gataatatcg ctgacgattc ttggctattt   420
gggaccttga aagtataccc tgagcgtcat gaagtctaca aggcgaataa gttactgagt   480
ttgaccccaa aagaatttga actcttgctc tatcttatga aacatcccaa catgacactg   540
actagagagc gtcttttgga acgtatctgg gggtatgact ttgggcagga aacacgtttg   600
gtggacgttc atattggtaa gttgagggaa aaaattgaag acaatcctaa agcccctcaa   660
tttattcgaa ccattcgggg ttatggttat aagttcaagg agtta                   705

<210>   4342
<211>   235
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   response regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903934 (e-134)

<400>   4342
Met Thr Lys Gln Val Leu Leu Val Asp Asp Glu Glu His Ile Leu Lys 
1               5                   10                  15      

Leu Leu Asp Tyr His Leu Ser Lys Glu Gly Phe Ser Thr Gln Leu Val 
            20                  25                  30          

Thr Asn Gly Arg Lys Ala Leu Ala Leu Ala Glu Thr Glu Pro Phe Asp 
        35                  40                  45              

Phe Ile Leu Leu Asp Ile Met Leu Pro Gln Leu Asp Gly Met Glu Val 
    50                  55                  60                  

Cys Lys Arg Leu Arg Ala Lys Gly Val Lys Thr Pro Ile Met Met Val 
65                  70                  75                  80  

Ser Ala Lys Ser Asp Glu Phe Asp Lys Val Leu Ala Leu Glu Leu Gly 
                85                  90                  95      

Ala Asp Asp Tyr Leu Thr Lys Pro Phe Ser Pro Arg Glu Leu Leu Ala 
            100                 105                 110         

Arg Val Lys Ala Val Leu Arg Arg Thr Lys Gly Glu Gln Glu Gly Asp 
        115                 120                 125             

Asp Ser Asp Asn Ile Ala Asp Asp Ser Trp Leu Phe Gly Thr Leu Lys 
    130                 135                 140                 

Val Tyr Pro Glu Arg His Glu Val Tyr Lys Ala Asn Lys Leu Leu Ser 
145                 150                 155                 160 

Leu Thr Pro Lys Glu Phe Glu Leu Leu Leu Tyr Leu Met Lys His Pro 
                165                 170                 175     

Asn Met Thr Leu Thr Arg Glu Arg Leu Leu Glu Arg Ile Trp Gly Tyr 
            180                 185                 190         

Asp Phe Gly Gln Glu Thr Arg Leu Val Asp Val His Ile Gly Lys Leu 
        195                 200                 205             

Arg Glu Lys Ile Glu Asp Asn Pro Lys Ala Pro Gln Phe Ile Arg Thr 
    210                 215                 220                 

Ile Arg Gly Tyr Gly Tyr Lys Phe Lys Glu Leu 
225                 230                 235 

<210>   4343
<211>   1329
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4343
atgaaacgct accttcaatt ttggctagtc aatctaagtg ttagcctcat tctgattgca   60
gggatggcat taacttggat cagtaaaggc atcggtctct ttcttctagc cctttctttg   120
ggactaggtg gctactggct cttttgcctt tggaaatggg aagttgcttt tgagaccttg   180

caccaacctc tcttgaccag tagtgaatac tttttagaaa aagggcaaga agacttaaag   240
tctttggctc agtatgtgtc tggcctaaaa accaaagtct cccaacagga tcagcaatac   300
aaggatctag ccgaaacaat ggaggttctt ctgtcgcacc taaccatggg gacgttttta   360
gtttccgctc aaggtcagat gttattatcc agtcgctctc tgcctcatta ttttcccgat   420
gtggacggcg acataagttc acttgatgac ctcaaacgga tggatattcg gaatttagtt   480
caccaagcct ttgatcaaaa aacaaggtta aaacaagaag taagtgggtt tcatgagggt   540
gacttgattt tagaagtgac agcagttccc gtttttagcc ccacccaatc tgtggaagct   600
gtgctcgtct tgctatatga tttaacaacg attagaactt atgaaaagtt aaatttagcc   660
tttgtctcaa atgcctccca tgaattgagg acaccagtta cttcgattaa gggctttgct   720
gaaaccatta aggggatgtc agctgaagaa gaagcgctca aggatgactt tctagacatt   780
atttacaaag aaagtttgcg tcttgagcat attgttgagc atcttcttac cttatctaag   840
gctcaacaaa tgcctataca atggacgacc ctttctttgg cagaatttgt acaggatttg   900
actcaaagct tgcaacctca gctcaagaag aaggatttac agctaaaggt gcaggtgcca   960
gatgatgtca ccctcgtatc agatagtcaa ttactttccc aaatcttact caatctttta   1020
tccaatgcca tccgttacac tgaacaaggg ggaaaaattg aggtcaagac ccaaaaggtg   1080
aacgaaggca ttaagatttc tgtatcagat acagggattg gtattagtca attagagcag   1140
gatcgtattt ttgaacgttt ttaccgagtt aataaaggtc gaagcagaca aactggtggc   1200
actggtcttg gccttgccat tgtcaaagaa ctcagtcaat tattaggtgg ccaagtcacg   1260
gtgacgagtc agcttggcag aggcagttgc ttcacgattt ttcttcctaa ccaatctttc   1320
gcacaggac                                                           1329

<210>   4344
<211>   443
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase PnpS (pnpS)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903935 (0.E+01)

<400>   4344
Met Lys Arg Tyr Leu Gln Phe Trp Leu Val Asn Leu Ser Val Ser Leu 
1               5                   10                  15      

Ile Leu Ile Ala Gly Met Ala Leu Thr Trp Ile Ser Lys Gly Ile Gly 
            20                  25                  30          

Leu Phe Leu Leu Ala Leu Ser Leu Gly Leu Gly Gly Tyr Trp Leu Phe 
        35                  40                  45              

Cys Leu Trp Lys Trp Glu Val Ala Phe Glu Thr Leu His Gln Pro Leu 
    50                  55                  60                  

Leu Thr Ser Ser Glu Tyr Phe Leu Glu Lys Gly Gln Glu Asp Leu Lys 
65                  70                  75                  80  

Ser Leu Ala Gln Tyr Val Ser Gly Leu Lys Thr Lys Val Ser Gln Gln 
                85                  90                  95      

Asp Gln Gln Tyr Lys Asp Leu Ala Glu Thr Met Glu Val Leu Leu Ser 
            100                 105                 110         

His Leu Thr Met Gly Thr Phe Leu Val Ser Ala Gln Gly Gln Met Leu 
        115                 120                 125             

Leu Ser Ser Arg Ser Leu Pro His Tyr Phe Pro Asp Val Asp Gly Asp 
    130                 135                 140                 

Ile Ser Ser Leu Asp Asp Leu Lys Arg Met Asp Ile Arg Asn Leu Val 
145                 150                 155                 160 

His Gln Ala Phe Asp Gln Lys Thr Arg Leu Lys Gln Glu Val Ser Gly 
                165                 170                 175     

Phe His Glu Gly Asp Leu Ile Leu Glu Val Thr Ala Val Pro Val Phe 
            180                 185                 190         

Ser Pro Thr Gln Ser Val Glu Ala Val Leu Val Leu Leu Tyr Asp Leu 
        195                 200                 205             

Thr Thr Ile Arg Thr Tyr Glu Lys Leu Asn Leu Ala Phe Val Ser Asn 
    210                 215                 220                 

Ala Ser His Glu Leu Arg Thr Pro Val Thr Ser Ile Lys Gly Phe Ala 
225                 230                 235                 240 

Glu Thr Ile Lys Gly Met Ser Ala Glu Glu Glu Ala Leu Lys Asp Asp 
                245                 250                 255     

Phe Leu Asp Ile Ile Tyr Lys Glu Ser Leu Arg Leu Glu His Ile Val 
            260                 265                 270         

Glu His Leu Leu Thr Leu Ser Lys Ala Gln Gln Met Pro Ile Gln Trp 
        275                 280                 285             

Thr Thr Leu Ser Leu Ala Glu Phe Val Gln Asp Leu Thr Gln Ser Leu 
    290                 295                 300                 

Gln Pro Gln Leu Lys Lys Lys Asp Leu Gln Leu Lys Val Gln Val Pro 
305                 310                 315                 320 

Asp Asp Val Thr Leu Val Ser Asp Ser Gln Leu Leu Ser Gln Ile Leu 
                325                 330                 335     

Leu Asn Leu Leu Ser Asn Ala Ile Arg Tyr Thr Glu Gln Gly Gly Lys 
            340                 345                 350         

Ile Glu Val Lys Thr Gln Lys Val Asn Glu Gly Ile Lys Ile Ser Val 
        355                 360                 365             

Ser Asp Thr Gly Ile Gly Ile Ser Gln Leu Glu Gln Asp Arg Ile Phe 
    370                 375                 380                 

Glu Arg Phe Tyr Arg Val Asn Lys Gly Arg Ser Arg Gln Thr Gly Gly 
385                 390                 395                 400 

Thr Gly Leu Gly Leu Ala Ile Val Lys Glu Leu Ser Gln Leu Leu Gly 
                405                 410                 415     

Gly Gln Val Thr Val Thr Ser Gln Leu Gly Arg Gly Ser Cys Phe Thr 
            420                 425                 430         

Ile Phe Leu Pro Asn Gln Ser Phe Ala Gln Asp 
        435                 440             

<210>   4345
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4345
gtgttggctt gtatattccg tggtttcggt tttagcttca ataaatttat tatctgtgac   60
cacttgttga ccttgtttgg agtggataaa gctgataaaa tcttgacc                108

<210>   4346
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4346
Met Leu Ala Cys Ile Phe Arg Gly Phe Gly Phe Ser Phe Asn Lys Phe 
1               5                   10                  15      

Ile Ile Cys Asp His Leu Leu Thr Leu Phe Gly Val Asp Lys Ala Asp 
            20                  25                  30          

Lys Ile Leu Thr 
        35      

<210>   4347
<211>   873
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4347
atgaaattca aaaaaatgct tactcttgca gccattggct tatcaggatt tgggcttgtt   60
gcctgtggca atcagtcagc tgcttccaaa cagtcagctt caggaacgat tgaggtgatt   120
tcacgagaaa atggctctgg gacacggggt gccttcacag aaatcacagg gattctcaaa   180
aaagacggtg ataaaaaaat tgacaacact gccaaaacag ctgtgattca aaatagtaca   240
gaaggtgttc tctcagcagt tcaagggaat gctaatgcta tcggctacat ctccttggga   300
tctttaacga aatctgtcaa ggctttagag attgatggtg tcaaggctag tcgagacaca   360
gttttagatg gtgaataccc tcttcaacgt cccttcaaca ttgtttggtc ttctaatctt   420
tccaagctag gtcaagattt tatcagcttt atccactcca aacaaggtca acaagtggtc   480
acagataata aatttattga agctaaaacc gaaaccacgg aatatacaag ccaacactta   540
tcaggcaagt tgtctgttgt aggttccact tcagtatctt ctttaatgga aaaattagca   600
gaagcttata aaaaagaaaa tccagaagtt acgattgata ttacctctaa tgggtcttca   660
gcaggtatta ccgctgttaa ggagaaaacc gctgatattg gtatggtttc tagggaatta   720
actcctgaag aaggtaagag tctcacccat gatgctattg ctttagacgg tattgctgtt   780
gtggtcaata atgacaataa ggcaagccaa gtcagtatgg ctgaacttgc agacgttttt   840
agtggcaaat taaccacctg ggacaagatt aaa                                873

<210>   4348
<211>   291
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate ABC transporter, phosphate-binding protein (pstS)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903936 (e-160)

<400>   4348
Met Lys Phe Lys Lys Met Leu Thr Leu Ala Ala Ile Gly Leu Ser Gly 
1               5                   10                  15      

Phe Gly Leu Val Ala Cys Gly Asn Gln Ser Ala Ala Ser Lys Gln Ser 
            20                  25                  30          

Ala Ser Gly Thr Ile Glu Val Ile Ser Arg Glu Asn Gly Ser Gly Thr 
        35                  40                  45              

Arg Gly Ala Phe Thr Glu Ile Thr Gly Ile Leu Lys Lys Asp Gly Asp 
    50                  55                  60                  

Lys Lys Ile Asp Asn Thr Ala Lys Thr Ala Val Ile Gln Asn Ser Thr 
65                  70                  75                  80  

Glu Gly Val Leu Ser Ala Val Gln Gly Asn Ala Asn Ala Ile Gly Tyr 
                85                  90                  95      

Ile Ser Leu Gly Ser Leu Thr Lys Ser Val Lys Ala Leu Glu Ile Asp 
            100                 105                 110         

Gly Val Lys Ala Ser Arg Asp Thr Val Leu Asp Gly Glu Tyr Pro Leu 
        115                 120                 125             

Gln Arg Pro Phe Asn Ile Val Trp Ser Ser Asn Leu Ser Lys Leu Gly 
    130                 135                 140                 

Gln Asp Phe Ile Ser Phe Ile His Ser Lys Gln Gly Gln Gln Val Val 
145                 150                 155                 160 

Thr Asp Asn Lys Phe Ile Glu Ala Lys Thr Glu Thr Thr Glu Tyr Thr 
                165                 170                 175     

Ser Gln His Leu Ser Gly Lys Leu Ser Val Val Gly Ser Thr Ser Val 
            180                 185                 190         

Ser Ser Leu Met Glu Lys Leu Ala Glu Ala Tyr Lys Lys Glu Asn Pro 
        195                 200                 205             

Glu Val Thr Ile Asp Ile Thr Ser Asn Gly Ser Ser Ala Gly Ile Thr 
    210                 215                 220                 

Ala Val Lys Glu Lys Thr Ala Asp Ile Gly Met Val Ser Arg Glu Leu 
225                 230                 235                 240 

Thr Pro Glu Glu Gly Lys Ser Leu Thr His Asp Ala Ile Ala Leu Asp 
                245                 250                 255     

Gly Ile Ala Val Val Val Asn Asn Asp Asn Lys Ala Ser Gln Val Ser 
            260                 265                 270         

Met Ala Glu Leu Ala Asp Val Phe Ser Gly Lys Leu Thr Thr Trp Asp 
        275                 280                 285             

Lys Ile Lys 
    290     

<210>   4349
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4349
ttgtcacatc ttgtcctttc tagtgaagaa agtaagggag atacgacacc tccctacttg   60
ccttctttat cttattgtac gatgaaacgt ctgcatctct ttagagattt atggagcaaa   120
cattttatt                                                           129

<210>   4350
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4350
Met Ser His Leu Val Leu Ser Ser Glu Glu Ser Lys Gly Asp Thr Thr 
1               5                   10                  15      

Pro Pro Tyr Leu Pro Ser Leu Ser Tyr Cys Thr Met Lys Arg Leu His 
            20                  25                  30          


Leu Phe Arg Asp Leu Trp Ser Lys His Phe Ile 
        35                  40              

<210>   4351
<211>   861
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4351
gtgacaaaac aagccttcaa agaagcagtt tttagggcaa tttttttcat gagtgcaaca   60
gtagctgttg tagctatttt gctaatctgt ttctttattt ttagtaatgg cttacctttc   120
atagctaact acggctttgc ccgtttttta ttaggcagtg attggtcgcc aacgaacatt   180
ccggcaagct atggtatttt accaatgatc gttggttcct tattaattac cttaggagcg   240
attgtgattg gggtgccaac aggcatcttg acatcggtgt ttatggttta ttattgtcca   300
aagcccgtct atggcttctt aaaatcagct atcaacttga tggcagccat tccatctatt   360
gtttatggtt ttttcggcct acaattattg gtgccttgga ttagaagctt tttaggaaat   420
ggcatgagtg tcctaaccgc ttcgttacta ttaggaataa tgattttgcc aaccattatc   480
agtttgtcag aatctgctat ccgaacagtt cccaaaacgt attattctgg tagcttggct   540
ctaggagcta gtcatgaacg gagtattttt agtgtcatct tgccagctgc gagatctggt   600
attttatcag cagttatttt aggaatcggt cgcgcagtag gtgaaaccat ggcagttatt   660
ttggtggcag gcaaccagcc gattattcca agtggactct tttcaggaac cagaacctta   720
acaaccaata ttgttctgga aatggcttac gcatcaggtc agcataggga agcccttatt   780
gcaacctcag cagttctctt tttccttatt ctcttgatta atgcctactt tgcctacttg   840
aaaggaaaat catcttatga g                                             861


<210>   4352
<211>   287
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate ABC transporter, permease protein (pstC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903937 (e-157)

<400>   4352
Met Thr Lys Gln Ala Phe Lys Glu Ala Val Phe Arg Ala Ile Phe Phe 
1               5                   10                  15      

Met Ser Ala Thr Val Ala Val Val Ala Ile Leu Leu Ile Cys Phe Phe 
            20                  25                  30          

Ile Phe Ser Asn Gly Leu Pro Phe Ile Ala Asn Tyr Gly Phe Ala Arg 
        35                  40                  45              

Phe Leu Leu Gly Ser Asp Trp Ser Pro Thr Asn Ile Pro Ala Ser Tyr 
    50                  55                  60                  

Gly Ile Leu Pro Met Ile Val Gly Ser Leu Leu Ile Thr Leu Gly Ala 
65                  70                  75                  80  

Ile Val Ile Gly Val Pro Thr Gly Ile Leu Thr Ser Val Phe Met Val 
                85                  90                  95      

Tyr Tyr Cys Pro Lys Pro Val Tyr Gly Phe Leu Lys Ser Ala Ile Asn 
            100                 105                 110         

Leu Met Ala Ala Ile Pro Ser Ile Val Tyr Gly Phe Phe Gly Leu Gln 
        115                 120                 125             

Leu Leu Val Pro Trp Ile Arg Ser Phe Leu Gly Asn Gly Met Ser Val 
    130                 135                 140                 

Leu Thr Ala Ser Leu Leu Leu Gly Ile Met Ile Leu Pro Thr Ile Ile 
145                 150                 155                 160 

Ser Leu Ser Glu Ser Ala Ile Arg Thr Val Pro Lys Thr Tyr Tyr Ser 
                165                 170                 175     

Gly Ser Leu Ala Leu Gly Ala Ser His Glu Arg Ser Ile Phe Ser Val 
            180                 185                 190         

Ile Leu Pro Ala Ala Arg Ser Gly Ile Leu Ser Ala Val Ile Leu Gly 
        195                 200                 205             

Ile Gly Arg Ala Val Gly Glu Thr Met Ala Val Ile Leu Val Ala Gly 
    210                 215                 220                 

Asn Gln Pro Ile Ile Pro Ser Gly Leu Phe Ser Gly Thr Arg Thr Leu 
225                 230                 235                 240 

Thr Thr Asn Ile Val Leu Glu Met Ala Tyr Ala Ser Gly Gln His Arg 
                245                 250                 255     

Glu Ala Leu Ile Ala Thr Ser Ala Val Leu Phe Phe Leu Ile Leu Leu 
            260                 265                 270         

Ile Asn Ala Tyr Phe Ala Tyr Leu Lys Gly Lys Ser Ser Tyr Glu 
        275                 280                 285         

<210>   4353
<211>   813
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4353
atgagtaaat acctgctaaa acttctcgtt tattgttttt cagctttaac ctttggctct   60
ctctttttaa tcattggttt tatcctcatc aaaggcttac ctcatctaag tctatccctc   120
ttttcttgga cttatacttc tgagaacatt tcccttatgc cagcgattat ttccaccgtt   180
attctggtct ttggtgctct tcttttagcc ttgcccatag ggatttttgc tggtttttat   240
cttgtggaat atacaaaaaa agattccctt tgtgttaaaa tcatgcgatt ggcctcagat   300
accttatctg ggattccttc cattgttttt ggtctgtttg gcatgctctt ctttgtagtc   360
ttcttaggtt ttcaatactc tctgttatca ggaatcttaa cctcagttat catggtgttg   420
ccagtcatta ttcgctcaac agaagaagcc cttttatctg ttagtgatag catgcgtcaa   480
gcaagttatg gacttggggc aggtaagtta cggactgttt ttagaattgt tctaccagtt   540
gccatgccag gtattttagc tggagtgata ctagctattg gccgtatcgt tggtgaaaca   600
gctgccctca tgtatacatt aggtacctct accaatacgc caagtagtct catgtcttca   660
ggccgttctc tagccctaca tatgtatatg ctgtcaagtg aggggctaca tgtcaatgaa   720
gcctatgcta ccggcgtgat tttgattatt actgttttaa tgataaatac tctatcaagc   780
ttattatctc gaaaacttgt gaaaggagct tcc                                813

<210>   4354
<211>   271
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate ABC transporter, permease protein (pstA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903938 (e-146)

<400>   4354
Met Ser Lys Tyr Leu Leu Lys Leu Leu Val Tyr Cys Phe Ser Ala Leu 
1               5                   10                  15      

Thr Phe Gly Ser Leu Phe Leu Ile Ile Gly Phe Ile Leu Ile Lys Gly 
            20                  25                  30          

Leu Pro His Leu Ser Leu Ser Leu Phe Ser Trp Thr Tyr Thr Ser Glu 
        35                  40                  45              

Asn Ile Ser Leu Met Pro Ala Ile Ile Ser Thr Val Ile Leu Val Phe 
    50                  55                  60                  

Gly Ala Leu Leu Leu Ala Leu Pro Ile Gly Ile Phe Ala Gly Phe Tyr 
65                  70                  75                  80  

Leu Val Glu Tyr Thr Lys Lys Asp Ser Leu Cys Val Lys Ile Met Arg 
                85                  90                  95      

Leu Ala Ser Asp Thr Leu Ser Gly Ile Pro Ser Ile Val Phe Gly Leu 
            100                 105                 110         

Phe Gly Met Leu Phe Phe Val Val Phe Leu Gly Phe Gln Tyr Ser Leu 
        115                 120                 125             

Leu Ser Gly Ile Leu Thr Ser Val Ile Met Val Leu Pro Val Ile Ile 
    130                 135                 140                 

Arg Ser Thr Glu Glu Ala Leu Leu Ser Val Ser Asp Ser Met Arg Gln 
145                 150                 155                 160 

Ala Ser Tyr Gly Leu Gly Ala Gly Lys Leu Arg Thr Val Phe Arg Ile 
                165                 170                 175     

Val Leu Pro Val Ala Met Pro Gly Ile Leu Ala Gly Val Ile Leu Ala 
            180                 185                 190         

Ile Gly Arg Ile Val Gly Glu Thr Ala Ala Leu Met Tyr Thr Leu Gly 
        195                 200                 205             

Thr Ser Thr Asn Thr Pro Ser Ser Leu Met Ser Ser Gly Arg Ser Leu 
    210                 215                 220                 

Ala Leu His Met Tyr Met Leu Ser Ser Glu Gly Leu His Val Asn Glu 
225                 230                 235                 240 

Ala Tyr Ala Thr Gly Val Ile Leu Ile Ile Thr Val Leu Met Ile Asn 
                245                 250                 255     

Thr Leu Ser Ser Leu Leu Ser Arg Lys Leu Val Lys Gly Ala Ser 
            260                 265                 270     

<210>   4355
<211>   750
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4355
atgggaacat tttcagtcag acacctagac ttattttacg gggattttca agccttaaaa   60
aatatttcga ttcaattacc agaaagacag attactgcct tgataggccc atctggttgt   120
ggcaaatcaa cttttctaaa aacccttaac cggatgaacg atttggttcc ttcttgccat   180
attgaaggcc aagtcctctt agatgagcaa gatatttata gtagcaaatt caaccttaat   240
cagctacgta agcgtgtagg gatggttttt caacagccta atccctttgc catgtctatc   300
tatgataacg tggcttatgg cccaaggaca catggtattc gagacaaaaa acaattagat   360
gccttagtgg agaaatcttt aaaaggggca gccatttggg aagaagtcaa agatgatctt   420
aaaaagagtg ccatgtcctt atctggcggt cagcagcaac gcctttgcat tgcgcgagct   480
ttagcagtag aacctgatat tctgttaatg gatgagccga cttcagcctt agaccctatc   540
tccactttaa aaattgaaga cctcattcag caactaaaaa aggattatac gattatcatt   600
gttacccata acatgcaaca agcttcacgt atttcagata aaactgcttt tttcttaaca   660
ggagaaattt gcgaatttgg agataccgtt gacgtgttta ccaatccaaa agatcagcgc   720
acagaagact atatttcagg acggttcgga                                    750

<210>   4356
<211>   250
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate ABC transporter, ATP-binding protein (pstB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903939 (e-143)

<400>   4356
Met Gly Thr Phe Ser Val Arg His Leu Asp Leu Phe Tyr Gly Asp Phe 
1               5                   10                  15      

Gln Ala Leu Lys Asn Ile Ser Ile Gln Leu Pro Glu Arg Gln Ile Thr 
            20                  25                  30          

Ala Leu Ile Gly Pro Ser Gly Cys Gly Lys Ser Thr Phe Leu Lys Thr 
        35                  40                  45              

Leu Asn Arg Met Asn Asp Leu Val Pro Ser Cys His Ile Glu Gly Gln 
    50                  55                  60                  

Val Leu Leu Asp Glu Gln Asp Ile Tyr Ser Ser Lys Phe Asn Leu Asn 
65                  70                  75                  80  

Gln Leu Arg Lys Arg Val Gly Met Val Phe Gln Gln Pro Asn Pro Phe 
                85                  90                  95      

Ala Met Ser Ile Tyr Asp Asn Val Ala Tyr Gly Pro Arg Thr His Gly 
            100                 105                 110         

Ile Arg Asp Lys Lys Gln Leu Asp Ala Leu Val Glu Lys Ser Leu Lys 
        115                 120                 125             

Gly Ala Ala Ile Trp Glu Glu Val Lys Asp Asp Leu Lys Lys Ser Ala 
    130                 135                 140                 

Met Ser Leu Ser Gly Gly Gln Gln Gln Arg Leu Cys Ile Ala Arg Ala 
145                 150                 155                 160 

Leu Ala Val Glu Pro Asp Ile Leu Leu Met Asp Glu Pro Thr Ser Ala 
                165                 170                 175     

Leu Asp Pro Ile Ser Thr Leu Lys Ile Glu Asp Leu Ile Gln Gln Leu 
            180                 185                 190         

Lys Lys Asp Tyr Thr Ile Ile Ile Val Thr His Asn Met Gln Gln Ala 
        195                 200                 205             

Ser Arg Ile Ser Asp Lys Thr Ala Phe Phe Leu Thr Gly Glu Ile Cys 
    210                 215                 220                 

Glu Phe Gly Asp Thr Val Asp Val Phe Thr Asn Pro Lys Asp Gln Arg 
225                 230                 235                 240 

Thr Glu Asp Tyr Ile Ser Gly Arg Phe Gly 
                245                 250 

<210>   4357
<211>   648
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4357
atgagaaatc aatttgactt agaattgcat gaattagaac aatccttttt aggactaggg   60
caacttgtcc ttgaaacagc ttcaaaagcc ttactggcct tagcctccaa agacaaggag   120
atggcagagc taattatcaa taaggatcat gctatcaacc aaggtcaaag cgctatcgaa   180
ttgacctgtg cccgtttgtt ggccttgcag cagccacaag tgtctgacct tcgatttgtg   240
attagcatca tgtcttcttg ttcagacctt gaacgtatgg gagaccatat ggcaggcatt   300
gccaaagctg ttttgcaact aaaagaaaat caactagccc ctgacgaaga acagttacac   360
caaatgggta aattatccct cagcatgcta gccgatttat tggttgcctt tcctttgcac   420
caagcctcaa aagctattag tattgctcaa aaagatgaac agattgacca atattattat   480
gccttatcaa aggaaatcat tggacttatg aaagaccaag aaacctcaat tcccaatgga   540
actcaatacc tttatatcat agggcatctg gaacgcttcg ctgattacat tgctaacatt   600
tgtgaacgcc tagtctacct agaaacagga gaactagtgg atttgaat                648

<210>   4358
<211>   216
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphate transport system regulatory protein PhoU (phoU)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903940 (e-118)

<400>   4358
Met Arg Asn Gln Phe Asp Leu Glu Leu His Glu Leu Glu Gln Ser Phe 
1               5                   10                  15      

Leu Gly Leu Gly Gln Leu Val Leu Glu Thr Ala Ser Lys Ala Leu Leu 
            20                  25                  30          

Ala Leu Ala Ser Lys Asp Lys Glu Met Ala Glu Leu Ile Ile Asn Lys 
        35                  40                  45              

Asp His Ala Ile Asn Gln Gly Gln Ser Ala Ile Glu Leu Thr Cys Ala 
    50                  55                  60                  

Arg Leu Leu Ala Leu Gln Gln Pro Gln Val Ser Asp Leu Arg Phe Val 
65                  70                  75                  80  

Ile Ser Ile Met Ser Ser Cys Ser Asp Leu Glu Arg Met Gly Asp His 
                85                  90                  95      

Met Ala Gly Ile Ala Lys Ala Val Leu Gln Leu Lys Glu Asn Gln Leu 
            100                 105                 110         

Ala Pro Asp Glu Glu Gln Leu His Gln Met Gly Lys Leu Ser Leu Ser 
        115                 120                 125             

Met Leu Ala Asp Leu Leu Val Ala Phe Pro Leu His Gln Ala Ser Lys 
    130                 135                 140                 

Ala Ile Ser Ile Ala Gln Lys Asp Glu Gln Ile Asp Gln Tyr Tyr Tyr 
145                 150                 155                 160 

Ala Leu Ser Lys Glu Ile Ile Gly Leu Met Lys Asp Gln Glu Thr Ser 
                165                 170                 175     

Ile Pro Asn Gly Thr Gln Tyr Leu Tyr Ile Ile Gly His Leu Glu Arg 
            180                 185                 190         

Phe Ala Asp Tyr Ile Ala Asn Ile Cys Glu Arg Leu Val Tyr Leu Glu 
        195                 200                 205             

Thr Gly Glu Leu Val Asp Leu Asn 
    210                 215     

<210>   4359
<211>   423
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4359
ttgaccaatt taagcagtgt agatagtgag gagttgtttc aattctatcg tgaacgaggg   60
aatgctgaaa actttatcaa agaaaggaaa gcaggattct ttggggataa gacagatagt   120
tcgaccatga ttaagaatga agtacgtatg atgatgggct gtctggctta taatctctac   180
ctctttttaa agcagctagc tggtgatgaa gtaaagtcct tgactatcaa gcgttttcga   240
cgtctcttcc ttcatattgc cggaaaatat gtctctactg ctagacgaca tattctcaaa   300
ttctcaagtc tatacgccta ttcaaaacag tttcaagcct tatttgatac aatctgccag   360
ataaatctga tactccctgt tccatataga gctagagggc aggggaaaac atgcctaaca   420
gaa                                                                 423

<210>   4360
<211>   141
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase, IS1380-Spn1 related, truncation ( )
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903941 (3.E-75)

<400>   4360
Met Thr Asn Leu Ser Ser Val Asp Ser Glu Glu Leu Phe Gln Phe Tyr 
1               5                   10                  15      

Arg Glu Arg Gly Asn Ala Glu Asn Phe Ile Lys Glu Arg Lys Ala Gly 
            20                  25                  30          

Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Met Ile Lys Asn Glu Val 
        35                  40                  45              

Arg Met Met Met Gly Cys Leu Ala Tyr Asn Leu Tyr Leu Phe Leu Lys 
    50                  55                  60                  

Gln Leu Ala Gly Asp Glu Val Lys Ser Leu Thr Ile Lys Arg Phe Arg 
65                  70                  75                  80  

Arg Leu Phe Leu His Ile Ala Gly Lys Tyr Val Ser Thr Ala Arg Arg 
                85                  90                  95      

His Ile Leu Lys Phe Ser Ser Leu Tyr Ala Tyr Ser Lys Gln Phe Gln 
            100                 105                 110         

Ala Leu Phe Asp Thr Ile Cys Gln Ile Asn Leu Ile Leu Pro Val Pro 
        115                 120                 125             

Tyr Arg Ala Arg Gly Gln Gly Lys Thr Cys Leu Thr Glu 
    130                 135                 140     

<210>   4361
<211>   516
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4361
gtgagaagaa atctgataga tagtttgatt cagtatatgc ttataataga ggtaaacaac   60
tcaggaagtt cttgtaggtt gcgagagttt ggcgaaaaaa ttaaaagatt acgtttggct   120
aaaaaaatca gtcgttcaga attttgtggt gatgagtctg aattaagtat ccgtcaatta   180
attagaattg aaaatggaga atccagacca atactaacaa agttaaaata tattgctgaa   240
cgtttggggg ttgaagatta caagttgatg ccaagttata tagagttgga taaggaatac   300
ctagaattga agtatttctt gatgaggact cctacatacg aagatgaaac tatcgcccaa   360
aagaaagaga gtgtttttga taagattttt gaagagtatt atgataggct acctgaggaa   420
gaaagattta tcatcccaaa ttattcatat ctggcactaa cgaactacac agttcaaaaa   480
ttaccagaaa agctagttga aatactgtcc ttctgg                             516

<210>   4362
<211>   172
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903942 (2.E-78)

<400>   4362
Met Arg Arg Asn Leu Ile Asp Ser Leu Ile Gln Tyr Met Leu Ile Ile 
1               5                   10                  15      

Glu Val Asn Asn Ser Gly Ser Ser Cys Arg Leu Arg Glu Phe Gly Glu 
            20                  25                  30          

Lys Ile Lys Arg Leu Arg Leu Ala Lys Lys Ile Ser Arg Ser Glu Phe 
        35                  40                  45              

Cys Gly Asp Glu Ser Glu Leu Ser Ile Arg Gln Leu Ile Arg Ile Glu 
    50                  55                  60                  

Asn Gly Glu Ser Arg Pro Ile Leu Thr Lys Leu Lys Tyr Ile Ala Glu 
65                  70                  75                  80  

Arg Leu Gly Val Glu Asp Tyr Lys Leu Met Pro Ser Tyr Ile Glu Leu 
                85                  90                  95      

Asp Lys Glu Tyr Leu Glu Leu Lys Tyr Phe Leu Met Arg Thr Pro Thr 
            100                 105                 110         

Tyr Glu Asp Glu Thr Ile Ala Gln Lys Lys Glu Ser Val Phe Asp Lys 
        115                 120                 125             

Ile Phe Glu Glu Tyr Tyr Asp Arg Leu Pro Glu Glu Glu Arg Phe Ile 
    130                 135                 140                 

Ile Pro Asn Tyr Ser Tyr Leu Ala Leu Thr Asn Tyr Thr Val Gln Lys 
145                 150                 155                 160 

Leu Pro Glu Lys Leu Val Glu Ile Leu Ser Phe Trp 
                165                 170         

<210>   4363
<211>   1014
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4363
atggaaaaac aaaccgtcgc cgtcttgggg cctggttctt ggggaaccgc cctttcacaa   60
gtcttaaatg acaatggaca cgaggtacgt atttggggaa atcttcccga gcaaatcaat   120
gaaattaata cacaccatac taataagcac tactttaaag atgtcgttct agacgaaaat   180
atcattgcct acaccgactt agcagaaaca ttgaaagatg tggatgcgat tttgtttgtt   240
gtcccaacaa aagtgacacg acttgttgcc cagcaagttg cacaaacctt ggaccataag   300
gttatcatca tgcacgcatc aaagggatta gaacctgata gccataaacg attatcaacc   360
attcttgaag aagaaattcc tgaacatctc cgtagtgata tcgtcgttgt ttcagggcct   420
agtcatgcag aagagaccat tgtgcgtgac ctaactttaa taactgctgc ttctaaagat   480
ttacaaacag ctcaatacgt tcagaagcta tttagtaatc actacttccg actttatacc   540
aatacggatg ttatcggggt tgaaactgct ggtgctctta aaaatattat tgctgtcggt   600
gctggagctt tacatggtct tggatttggt gataatgcta aggcagccat catcgctcga   660
ggtttagcag aaatcacccg cctaggggta gcactcgggg ccagtccatt gacctatagc   720
ggcttatctg gtgtgggaga tttgatcgta acgggaactt ccatccactc tcgtaactgg   780
agagctggag atgctctcgg acgaggagaa tccctagctg atatagaagc taatatgggc   840
atggtaatcg aaggaatttc aacgactcga gcagcctatg aactagccca agaacttgga   900
gtctatatgc ccattacaca ggctatttac caagttattt atcacggaac caatatcaaa   960
gatgccattt atgacatcat gaacaatgaa tttaaagcag aaaatgagtg gtct         1014

<210>   4364
<211>   338
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycerol-3-phosphate dehydrogenase (NAD(P)+) (gpsA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903943 (0.E+01)

<400>   4364
Met Glu Lys Gln Thr Val Ala Val Leu Gly Pro Gly Ser Trp Gly Thr 
1               5                   10                  15      

Ala Leu Ser Gln Val Leu Asn Asp Asn Gly His Glu Val Arg Ile Trp 
            20                  25                  30          

Gly Asn Leu Pro Glu Gln Ile Asn Glu Ile Asn Thr His His Thr Asn 
        35                  40                  45              

Lys His Tyr Phe Lys Asp Val Val Leu Asp Glu Asn Ile Ile Ala Tyr 
    50                  55                  60                  

Thr Asp Leu Ala Glu Thr Leu Lys Asp Val Asp Ala Ile Leu Phe Val 
65                  70                  75                  80  

Val Pro Thr Lys Val Thr Arg Leu Val Ala Gln Gln Val Ala Gln Thr 
                85                  90                  95      

Leu Asp His Lys Val Ile Ile Met His Ala Ser Lys Gly Leu Glu Pro 
            100                 105                 110         

Asp Ser His Lys Arg Leu Ser Thr Ile Leu Glu Glu Glu Ile Pro Glu 
        115                 120                 125             

His Leu Arg Ser Asp Ile Val Val Val Ser Gly Pro Ser His Ala Glu 
    130                 135                 140                 

Glu Thr Ile Val Arg Asp Leu Thr Leu Ile Thr Ala Ala Ser Lys Asp 
145                 150                 155                 160 

Leu Gln Thr Ala Gln Tyr Val Gln Lys Leu Phe Ser Asn His Tyr Phe 
                165                 170                 175     

Arg Leu Tyr Thr Asn Thr Asp Val Ile Gly Val Glu Thr Ala Gly Ala 
            180                 185                 190         

Leu Lys Asn Ile Ile Ala Val Gly Ala Gly Ala Leu His Gly Leu Gly 
        195                 200                 205             

Phe Gly Asp Asn Ala Lys Ala Ala Ile Ile Ala Arg Gly Leu Ala Glu 
    210                 215                 220                 

Ile Thr Arg Leu Gly Val Ala Leu Gly Ala Ser Pro Leu Thr Tyr Ser 
225                 230                 235                 240 

Gly Leu Ser Gly Val Gly Asp Leu Ile Val Thr Gly Thr Ser Ile His 
                245                 250                 255     

Ser Arg Asn Trp Arg Ala Gly Asp Ala Leu Gly Arg Gly Glu Ser Leu 
            260                 265                 270         

Ala Asp Ile Glu Ala Asn Met Gly Met Val Ile Glu Gly Ile Ser Thr 
        275                 280                 285             

Thr Arg Ala Ala Tyr Glu Leu Ala Gln Glu Leu Gly Val Tyr Met Pro 
    290                 295                 300                 

Ile Thr Gln Ala Ile Tyr Gln Val Ile Tyr His Gly Thr Asn Ile Lys 
305                 310                 315                 320 

Asp Ala Ile Tyr Asp Ile Met Asn Asn Glu Phe Lys Ala Glu Asn Glu 
                325                 330                 335     

Trp Ser 
        

<210>   4365
<211>   897
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4365
atgacatcaa aagttagaaa ggcagtcatc cctgctgctg gactaggaac tcgattttta   60
ccagcaacca aggcccttgc caaagaaatg ttgccaatcg tagacaaacc aactatccag   120
tttatcgtgg aagaagctct caaatcaggt attgaagata ttctagttgt cactggtaaa   180
tcaaaacgtt ctattgagga ccactttgat tcaaacttcg aattggaata taacctcaaa   240
gaaaaaggga aaacagatct tttgaagcta gttgataaaa caactgacat gcgtctgcat   300
tttatccgcc aaactcatcc acgcggtctc ggagatgctg ttttgcaagc caaggctttc   360
gtcggaaatg aaccttttgt cgttatgctt ggtgatgact tgatggatat cacagacgaa   420
aaggctgttc cacttaccaa acaactcatg gatgactacg agcgtaccca cgcgtctact   480
atcgctgtca tgccagtccc tcatgacgaa gtatctgctt acggggttat tgctccgcaa   540
ggcgaaggaa aagatggtct ttacagtgtt gaaacctttg ttgaaaaacc agctccagag   600
gacgctccta gcgaccttgc tattatcgga cgctacctcc tcacgcctga aatttttgag   660
attctcgaaa agcaagctcc aggtgcagga aatgaaattc agctgacaga tgcaatcgac   720
accctcaata aaacacaacg tgtatttgct cgtgagttca aaggggctcg ttacgatgtc   780
ggagacaagt ttggcttcat gaaaacatcc atcgactacg ccctcaaaca cccacaagtc   840
aaagatgatt tgaagaatta cctcatccaa cttggaaaag aattgactga gaaggaa      897

<210>   4366
<211>   299
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   UTP-glucose-1-phosphate uridylyltransferase (galU)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903944 (e-167)

<400>   4366
Met Thr Ser Lys Val Arg Lys Ala Val Ile Pro Ala Ala Gly Leu Gly 
1               5                   10                  15      

Thr Arg Phe Leu Pro Ala Thr Lys Ala Leu Ala Lys Glu Met Leu Pro 
            20                  25                  30          

Ile Val Asp Lys Pro Thr Ile Gln Phe Ile Val Glu Glu Ala Leu Lys 
        35                  40                  45              

Ser Gly Ile Glu Asp Ile Leu Val Val Thr Gly Lys Ser Lys Arg Ser 
    50                  55                  60                  

Ile Glu Asp His Phe Asp Ser Asn Phe Glu Leu Glu Tyr Asn Leu Lys 
65                  70                  75                  80  

Glu Lys Gly Lys Thr Asp Leu Leu Lys Leu Val Asp Lys Thr Thr Asp 
                85                  90                  95      

Met Arg Leu His Phe Ile Arg Gln Thr His Pro Arg Gly Leu Gly Asp 
            100                 105                 110         

Ala Val Leu Gln Ala Lys Ala Phe Val Gly Asn Glu Pro Phe Val Val 
        115                 120                 125             

Met Leu Gly Asp Asp Leu Met Asp Ile Thr Asp Glu Lys Ala Val Pro 
    130                 135                 140                 

Leu Thr Lys Gln Leu Met Asp Asp Tyr Glu Arg Thr His Ala Ser Thr 
145                 150                 155                 160 

Ile Ala Val Met Pro Val Pro His Asp Glu Val Ser Ala Tyr Gly Val 
                165                 170                 175     

Ile Ala Pro Gln Gly Glu Gly Lys Asp Gly Leu Tyr Ser Val Glu Thr 
            180                 185                 190         

Phe Val Glu Lys Pro Ala Pro Glu Asp Ala Pro Ser Asp Leu Ala Ile 
        195                 200                 205             

Ile Gly Arg Tyr Leu Leu Thr Pro Glu Ile Phe Glu Ile Leu Glu Lys 
    210                 215                 220                 

Gln Ala Pro Gly Ala Gly Asn Glu Ile Gln Leu Thr Asp Ala Ile Asp 
225                 230                 235                 240 

Thr Leu Asn Lys Thr Gln Arg Val Phe Ala Arg Glu Phe Lys Gly Ala 
                245                 250                 255     

Arg Tyr Asp Val Gly Asp Lys Phe Gly Phe Met Lys Thr Ser Ile Asp 
            260                 265                 270         

Tyr Ala Leu Lys His Pro Gln Val Lys Asp Asp Leu Lys Asn Tyr Leu 
        275                 280                 285             

Ile Gln Leu Gly Lys Glu Leu Thr Glu Lys Glu 
    290                 295                 

<210>   4367
<211>   966
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4367
ttgcggacac tatcaaagaa aaagattatg gagaacaaat ttgtagaatt tatcgaaaac   60
aataaaaaag taatcatttc atcagttgca gttggtgttg tattggtatt agggtttgga   120
tggtattcat ataaccaaca acaagcagaa caacaagcaa aaattgtaca attagaaaaa   180
gatagcaaat cagacaaaga acaagttgat aaactatttg aatcatttga tgcatcttca   240
gatgaatcta tttctaaatt aaaagaacta tctgaaactt cacttaaaac cgatgcaggt   300
aaagactatc ttaataacaa agtcaaagaa tcatctaaag caattgtaga ttttcatttg   360
caaaaaggtt tggcttatga tgttaaagat tcagatgaca aatttaaaga taaagcaact   420
cttgaaacaa atgtaaaaga aattacaaaa caaattgatt ttatcaaaaa agttgatgaa   480
acttttaaac aagagaattt ggaagaaact cttaaatctc taaatgatct tgttgataaa   540
tatcaaaaac aaatcgaact tttgaagaaa gaagaagaaa aagctgctga aaaagctgct   600
gaaaaagcaa aggaatcttc tagtcaaagt aattcttctg gtagtgcttc taatgagtct   660
tataatggat cttccaattc aaatgtagat tatagttcat ctgaacaaac taatggatat   720
tcaaataatt atggcggtca agattattct ggttcaggag atagttcaac aaatggtgga   780
tcatcagaac aatattcatc tagcaattca aacagcggag caaataatgt ctacagatat   840
aaaggcactg gtgctgacgg ctatcaaaga tactactaca aagatcataa taatggagat   900
gtgtatgatg acgatggaaa ttaccttggg aactttggtg gcggcattgc agaacctagt   960
caacgc                                                              966

<210>   4368
<211>   322
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Surface protein pspA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902165 (4.E-06)

<400>   4368
Met Arg Thr Leu Ser Lys Lys Lys Ile Met Glu Asn Lys Phe Val Glu 
1               5                   10                  15      

Phe Ile Glu Asn Asn Lys Lys Val Ile Ile Ser Ser Val Ala Val Gly 
            20                  25                  30          

Val Val Leu Val Leu Gly Phe Gly Trp Tyr Ser Tyr Asn Gln Gln Gln 
        35                  40                  45              

Ala Glu Gln Gln Ala Lys Ile Val Gln Leu Glu Lys Asp Ser Lys Ser 
    50                  55                  60                  

Asp Lys Glu Gln Val Asp Lys Leu Phe Glu Ser Phe Asp Ala Ser Ser 
65                  70                  75                  80  

Asp Glu Ser Ile Ser Lys Leu Lys Glu Leu Ser Glu Thr Ser Leu Lys 
                85                  90                  95      

Thr Asp Ala Gly Lys Asp Tyr Leu Asn Asn Lys Val Lys Glu Ser Ser 
            100                 105                 110         

Lys Ala Ile Val Asp Phe His Leu Gln Lys Gly Leu Ala Tyr Asp Val 
        115                 120                 125             

Lys Asp Ser Asp Asp Lys Phe Lys Asp Lys Ala Thr Leu Glu Thr Asn 
    130                 135                 140                 

Val Lys Glu Ile Thr Lys Gln Ile Asp Phe Ile Lys Lys Val Asp Glu 
145                 150                 155                 160 

Thr Phe Lys Gln Glu Asn Leu Glu Glu Thr Leu Lys Ser Leu Asn Asp 
                165                 170                 175     

Leu Val Asp Lys Tyr Gln Lys Gln Ile Glu Leu Leu Lys Lys Glu Glu 
            180                 185                 190         

Glu Lys Ala Ala Glu Lys Ala Ala Glu Lys Ala Lys Glu Ser Ser Ser 
        195                 200                 205             

Gln Ser Asn Ser Ser Gly Ser Ala Ser Asn Glu Ser Tyr Asn Gly Ser 
    210                 215                 220                 

Ser Asn Ser Asn Val Asp Tyr Ser Ser Ser Glu Gln Thr Asn Gly Tyr 
225                 230                 235                 240 

Ser Asn Asn Tyr Gly Gly Gln Asp Tyr Ser Gly Ser Gly Asp Ser Ser 
                245                 250                 255     

Thr Asn Gly Gly Ser Ser Glu Gln Tyr Ser Ser Ser Asn Ser Asn Ser 
            260                 265                 270         

Gly Ala Asn Asn Val Tyr Arg Tyr Lys Gly Thr Gly Ala Asp Gly Tyr 
        275                 280                 285             

Gln Arg Tyr Tyr Tyr Lys Asp His Asn Asn Gly Asp Val Tyr Asp Asp 
    290                 295                 300                 

Asp Gly Asn Tyr Leu Gly Asn Phe Gly Gly Gly Ile Ala Glu Pro Ser 
305                 310                 315                 320 

Gln Arg 
        

<210>   4369
<211>   183
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4369
atgaaaatca aagagcaaac taggaagcta gccgcaggtt gctcaaagca ctgctttgag   60
gttgtagata gaactgacga agtcagctca aaacatggtt ttgaggttgt agatgaaact   120
gacgaagtca gtaaccatac ctacggtaag gcgatgctga cgtggtttga atttgatttt   180
cat                                                                 183

<210>   4370
<211>   61
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4370
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Gly Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Asn His Thr Tyr 
        35                  40                  45              

Gly Lys Ala Met Leu Thr Trp Phe Glu Phe Asp Phe His 
    50                  55                  60      

<210>   4371
<211>   675
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4371
atgaaggaaa tctttgatag acgttaccct gtgacgagtt tcttcctctt agtgacggcc   60
ttggtatttt tactaatgtt ggtcactgca ggcggaaact ttgacagggc agatacatta   120

tttcgatttg gagccatgta tgggccagct attcgcctct ttcccgagca ggtttggcgt   180
ctcttgtctg ccatttttgt tcatattggg tgggaacatt tcattgttaa tatgctttca   240
ctttattatc ttggaaggca ggtagaggag attttcggtt ctaagcagtt tttctttctc   300
tatcttttat caggaatgat gggcaatctc tttgtttttg tatttagtcc taaatcctta   360
gcagcaggcg cctctacctc tctttatggg ctatttgccg cgattattgt tcttcgctat   420
gcaactcgca atccttatat ccaacagcta gggcaatcct atctgacact ttttgtggtt   480
aacattattg gaagtgttct gattccagga atcagcctag caggccatat cggtggtgca   540
gttggtggcg catttctagc agttatcttt ccagttagag gagaaaaacg gatgtataac   600
accagccaga gattaggagc ggtagtcttg ttcgtaggac tcgccatttt gcttttctac   660
aagggaatgg gattg                                                    675

<210>   4372
<211>   225
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903945 (e-126)

<400>   4372
Met Lys Glu Ile Phe Asp Arg Arg Tyr Pro Val Thr Ser Phe Phe Leu 
1               5                   10                  15      

Leu Val Thr Ala Leu Val Phe Leu Leu Met Leu Val Thr Ala Gly Gly 
            20                  25                  30          

Asn Phe Asp Arg Ala Asp Thr Leu Phe Arg Phe Gly Ala Met Tyr Gly 
        35                  40                  45              

Pro Ala Ile Arg Leu Phe Pro Glu Gln Val Trp Arg Leu Leu Ser Ala 
    50                  55                  60                  

Ile Phe Val His Ile Gly Trp Glu His Phe Ile Val Asn Met Leu Ser 
65                  70                  75                  80  

Leu Tyr Tyr Leu Gly Arg Gln Val Glu Glu Ile Phe Gly Ser Lys Gln 
                85                  90                  95      

Phe Phe Phe Leu Tyr Leu Leu Ser Gly Met Met Gly Asn Leu Phe Val 
            100                 105                 110         

Phe Val Phe Ser Pro Lys Ser Leu Ala Ala Gly Ala Ser Thr Ser Leu 
        115                 120                 125             

Tyr Gly Leu Phe Ala Ala Ile Ile Val Leu Arg Tyr Ala Thr Arg Asn 
    130                 135                 140                 

Pro Tyr Ile Gln Gln Leu Gly Gln Ser Tyr Leu Thr Leu Phe Val Val 
145                 150                 155                 160 

Asn Ile Ile Gly Ser Val Leu Ile Pro Gly Ile Ser Leu Ala Gly His 
                165                 170                 175     

Ile Gly Gly Ala Val Gly Gly Ala Phe Leu Ala Val Ile Phe Pro Val 
            180                 185                 190         

Arg Gly Glu Lys Arg Met Tyr Asn Thr Ser Gln Arg Leu Gly Ala Val 
        195                 200                 205             

Val Leu Phe Val Gly Leu Ala Ile Leu Leu Phe Tyr Lys Gly Met Gly 
    210                 215                 220                 

Leu 
225 

<210>   4373
<211>   537
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4373
atgaaatcgg aattacgcaa gcaagtcttg catgaaatga aggctatatc tcaagagcaa   60
aaacaggcta tagaccaagc tttaaccgag cggcttttac aacacccctt ttatcaagaa   120
gccaaggtca tcgcaaccta cctctctttt tctcatgagt ttcaaacgca ggaactgatt   180
gagcaggcgc tgaaggacgg caagaaggtt ttaataccca aaacttatcc caaggggcgc   240
atggactttg tggtctatga tccgcaacag ttggtaaaaa ctttctttgc cttactggag   300
ctacagggag atttggaagt ggtggatgca tctcagattg atttgattca tgttcctggt   360
ctggctttta cgacgaaagg atatcggata ggatacggtg gaggctatta tgaccgctat   420
ctggaacatt tttctggtcg tactttgagt acgatatatc cttgtcaaat tcaggacttt   480
atacctgaaa accatgatat tcctgttcag gaggtattaa ttgatgaagg aaatctt      537

<210>   4374
<211>   179
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   5-formyltetrahydrofolate cyclo-ligase family protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903946 (1.E-97)

<400>   4374
Met Lys Ser Glu Leu Arg Lys Gln Val Leu His Glu Met Lys Ala Ile 
1               5                   10                  15      

Ser Gln Glu Gln Lys Gln Ala Ile Asp Gln Ala Leu Thr Glu Arg Leu 
            20                  25                  30          

Leu Gln His Pro Phe Tyr Gln Glu Ala Lys Val Ile Ala Thr Tyr Leu 
        35                  40                  45              

Ser Phe Ser His Glu Phe Gln Thr Gln Glu Leu Ile Glu Gln Ala Leu 
    50                  55                  60                  

Lys Asp Gly Lys Lys Val Leu Ile Pro Lys Thr Tyr Pro Lys Gly Arg 
65                  70                  75                  80  

Met Asp Phe Val Val Tyr Asp Pro Gln Gln Leu Val Lys Thr Phe Phe 
                85                  90                  95      

Ala Leu Leu Glu Leu Gln Gly Asp Leu Glu Val Val Asp Ala Ser Gln 
            100                 105                 110         


Ile Asp Leu Ile His Val Pro Gly Leu Ala Phe Thr Thr Lys Gly Tyr 
        115                 120                 125             

Arg Ile Gly Tyr Gly Gly Gly Tyr Tyr Asp Arg Tyr Leu Glu His Phe 
    130                 135                 140                 

Ser Gly Arg Thr Leu Ser Thr Ile Tyr Pro Cys Gln Ile Gln Asp Phe 
145                 150                 155                 160 

Ile Pro Glu Asn His Asp Ile Pro Val Gln Glu Val Leu Ile Asp Glu 
                165                 170                 175     

Gly Asn Leu 
            

<210>   4375
<211>   1128
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4375
atgttagatt tgattcagac tagacgagat ttacaccaga ttccagagat tggcttggag   60
gagttcaaga ctcaggctta tttgctggat gtgattgaga aattgactac gggcaaggat   120
tttgttcaaa ttcgtacttg gcggacaggg attttggtct acctgcaggg aagtcagccg   180
gagcgaacca ttggttggcg gacagatatt gatggcctgc ctatcgtcga acaaacaggt   240
ctaccttttg cttctcaaca ccaaggtcgc atgcatgcct gtgtccatga ttttcatatg   300
accattgcct taggctgtct tgagcgcgcc cttgaggagc aacccaagaa taatctgctc   360
tttctatttc agcctgctga agaaaatgaa gctggtggta tgctcatgta tgaggacggt   420
gcttttggag attggttgcc agatcaattc tatggtctcc atgttcgtcc agatttgaaa   480
gtcggccaga ttgcgactaa tactcataca ctctttgcag gaacttgcga ggtgaagatc   540
cgtttcaaag gcaaaggtgg ccacgcagct tttcctcatg aagccaatga cgccttggtg   600
gcggctagtt actttgtgac ccaagtgcag tcagttgtta gccgcaatgt caacccaatc   660
gagggagcag tggtgacctt cggcgttttt caagctggaa ccaccaacaa tgtcatcaca   720
gacacagctt ttttacatgg aactattcgt gccttgacac aggacatgag tctcttggtg   780
caaaagaggg taaaaacagt tgcagaaggg gttgcagctg cctttgatat ggaagtcgaa   840
gtggaactca aacaaggtgg atacctacct gttgagaaca atccagcctt ggcgcgtgaa   900
ctgatggact tctttgacga aaaagacgga atcgagttga ttgatatcga acctgctatg   960
acaggcgagg actttggtta tctcctttca aaggttgatg gcgtgatgtt ttggctaggt   1020
atcgatagtc cctacgctct tcatcaccct caaatgagtc ctaaggaaga agtcttagct   1080
attggggtgg ctgcggtgtc tagtttcctg aaaaagaagg cagcagaa                1128


<210>   4376
<211>   376
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidase, M20/M25/M40 family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903947 (0.E+01)

<400>   4376
Met Leu Asp Leu Ile Gln Thr Arg Arg Asp Leu His Gln Ile Pro Glu 
1               5                   10                  15      

Ile Gly Leu Glu Glu Phe Lys Thr Gln Ala Tyr Leu Leu Asp Val Ile 
            20                  25                  30          

Glu Lys Leu Thr Thr Gly Lys Asp Phe Val Gln Ile Arg Thr Trp Arg 
        35                  40                  45              

Thr Gly Ile Leu Val Tyr Leu Gln Gly Ser Gln Pro Glu Arg Thr Ile 
    50                  55                  60                  

Gly Trp Arg Thr Asp Ile Asp Gly Leu Pro Ile Val Glu Gln Thr Gly 
65                  70                  75                  80  

Leu Pro Phe Ala Ser Gln His Gln Gly Arg Met His Ala Cys Val His 
                85                  90                  95      

Asp Phe His Met Thr Ile Ala Leu Gly Cys Leu Glu Arg Ala Leu Glu 
            100                 105                 110         

Glu Gln Pro Lys Asn Asn Leu Leu Phe Leu Phe Gln Pro Ala Glu Glu 
        115                 120                 125             

Asn Glu Ala Gly Gly Met Leu Met Tyr Glu Asp Gly Ala Phe Gly Asp 
    130                 135                 140                 

Trp Leu Pro Asp Gln Phe Tyr Gly Leu His Val Arg Pro Asp Leu Lys 
145                 150                 155                 160 

Val Gly Gln Ile Ala Thr Asn Thr His Thr Leu Phe Ala Gly Thr Cys 
                165                 170                 175     

Glu Val Lys Ile Arg Phe Lys Gly Lys Gly Gly His Ala Ala Phe Pro 
            180                 185                 190         

His Glu Ala Asn Asp Ala Leu Val Ala Ala Ser Tyr Phe Val Thr Gln 
        195                 200                 205             

Val Gln Ser Val Val Ser Arg Asn Val Asn Pro Ile Glu Gly Ala Val 
    210                 215                 220                 

Val Thr Phe Gly Val Phe Gln Ala Gly Thr Thr Asn Asn Val Ile Thr 
225                 230                 235                 240 

Asp Thr Ala Phe Leu His Gly Thr Ile Arg Ala Leu Thr Gln Asp Met 
                245                 250                 255     

Ser Leu Leu Val Gln Lys Arg Val Lys Thr Val Ala Glu Gly Val Ala 
            260                 265                 270         

Ala Ala Phe Asp Met Glu Val Glu Val Glu Leu Lys Gln Gly Gly Tyr 
        275                 280                 285             

Leu Pro Val Glu Asn Asn Pro Ala Leu Ala Arg Glu Leu Met Asp Phe 
    290                 295                 300                 

Phe Asp Glu Lys Asp Gly Ile Glu Leu Ile Asp Ile Glu Pro Ala Met 
305                 310                 315                 320 


Thr Gly Glu Asp Phe Gly Tyr Leu Leu Ser Lys Val Asp Gly Val Met 
                325                 330                 335     

Phe Trp Leu Gly Ile Asp Ser Pro Tyr Ala Leu His His Pro Gln Met 
            340                 345                 350         

Ser Pro Lys Glu Glu Val Leu Ala Ile Gly Val Ala Ala Val Ser Ser 
        355                 360                 365             

Phe Leu Lys Lys Lys Ala Ala Glu 
    370                 375     

<210>   4377
<211>   696
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4377
atgactgcta caaaaatgaa cgctcaagaa attatccaat ttatcgccaa tgctgaaaag   60
aaaaccagtg tcaaagtaac ctttgagggg caactcgcaa ctgctgtgcc tagctctgtt   120
gtcaaactag gaaatgtcct attcggagac tggaaggatg tggctccgct tcttgaaggt   180
ttggtagaaa atcaagatta tgttgtcgag caagatgctc gtaattctgc agttcctttg   240
ctagataagc gtgctatcaa cgctcgtatc gagccaggtg cgattatccg tgaccaggtg   300
gaaattggtg acaatgctgt tatcatgatg ggatctgtta tcaatatcgg tgctgaaatc   360
ggtgctggaa ccatgattga catgggtgcc atccttggtg gccgtgccat cgttggaaaa   420
aatagccacg ttggtgcagg tgcagttttg gcaggtgtga ttgagccagc tagtgctgaa   480
ccagtccgtg tcggagacaa tgttcttatc ggtgctaatg cagtggttat cgaaggagtc   540
caaatcggta gtggttcagt tgtcgcagca ggagctattg ttacccaaga tgtcccagaa   600
aacgtggtag tagcaggtgt tccagctcgt attatcaaag aaattgatgc ccaaactcaa   660
caaaaaacag cgctagagga tgcgcttcgt accttg                             696

<210>   4378
<211>   232
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase, putativ
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903948 (e-124)

<400>   4378
Met Thr Ala Thr Lys Met Asn Ala Gln Glu Ile Ile Gln Phe Ile Ala 
1               5                   10                  15      

Asn Ala Glu Lys Lys Thr Ser Val Lys Val Thr Phe Glu Gly Gln Leu 
            20                  25                  30          

Ala Thr Ala Val Pro Ser Ser Val Val Lys Leu Gly Asn Val Leu Phe 
        35                  40                  45              

Gly Asp Trp Lys Asp Val Ala Pro Leu Leu Glu Gly Leu Val Glu Asn 
    50                  55                  60                  

Gln Asp Tyr Val Val Glu Gln Asp Ala Arg Asn Ser Ala Val Pro Leu 
65                  70                  75                  80  

Leu Asp Lys Arg Ala Ile Asn Ala Arg Ile Glu Pro Gly Ala Ile Ile 
                85                  90                  95      

Arg Asp Gln Val Glu Ile Gly Asp Asn Ala Val Ile Met Met Gly Ser 
            100                 105                 110         

Val Ile Asn Ile Gly Ala Glu Ile Gly Ala Gly Thr Met Ile Asp Met 
        115                 120                 125             

Gly Ala Ile Leu Gly Gly Arg Ala Ile Val Gly Lys Asn Ser His Val 
    130                 135                 140                 

Gly Ala Gly Ala Val Leu Ala Gly Val Ile Glu Pro Ala Ser Ala Glu 
145                 150                 155                 160 

Pro Val Arg Val Gly Asp Asn Val Leu Ile Gly Ala Asn Ala Val Val 
                165                 170                 175     

Ile Glu Gly Val Gln Ile Gly Ser Gly Ser Val Val Ala Ala Gly Ala 
            180                 185                 190         

Ile Val Thr Gln Asp Val Pro Glu Asn Val Val Val Ala Gly Val Pro 
        195                 200                 205             

Ala Arg Ile Ile Lys Glu Ile Asp Ala Gln Thr Gln Gln Lys Thr Ala 
    210                 215                 220                 

Leu Glu Asp Ala Leu Arg Thr Leu 
225                 230         

<210>   4379
<211>   909
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4379
atgaatcagt atcagaaaaa gattgttaac ggaaaaattt attcgctcct atccggctta   60
atatggggaa tctgtggaat tttaggagag tacttcttta ctcattatca ggtgtcttcg   120
ggctggatta cctctatgcg tttgacactg gcagggagtc ttgtactcat ttggtctgca   180
atacaattaa aatcgcaagt gctagatatt tggcgagaca agaaaaatta cctgcccttt   240
ttagcctatg ctattttggg gattttttca gttcagtatt ttttctatct ctgtgtagaa   300
tactcaaatg ctacgacagc aactatttta cagtttatta gccctgtctt tatcctcttt   360
tacaatcgct tggtttatca aaaacgagcg tcaaaaagcg ctgttttcta tgttttggtt   420
gccatgctgg gtgtttgctt gatggcgaca aagggagacc tctctcagtt atccatgacg   480
ccgctagctc ttataacagg tttgctgagt gccatgggtg ttatgtttaa tgttatcttg   540
ccccaacctt ttgctaagcg ttatggtttt gttcctacgg ttgggtgggg gatgattttg   600
gcaggtttgt ttagcaatgt cctctcgccg gtttatcagc tttcctttac tcttgatatt   660
tggagtatct tgatttgcct cattatcgct ttctttggaa cggcttttgc ttttttcatt   720
tccatgaagg ctgtgtcctt ggtttctcct ttggtggttg ccgttatcag tgccagtgaa   780
cctctctctt ctgctctctt gagtgttttg ttcttaggat tagtagtgga ttggtccctc   840
cttctagcta tagccttgat tattttaccc atgatatttt tgtctataga agaagcgaaa   900
gaaagtaga                                                           909

<210>   4380
<211>   303
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903949 (e-170)

<400>   4380
Met Asn Gln Tyr Gln Lys Lys Ile Val Asn Gly Lys Ile Tyr Ser Leu 
1               5                   10                  15      

Leu Ser Gly Leu Ile Trp Gly Ile Cys Gly Ile Leu Gly Glu Tyr Phe 
            20                  25                  30          

Phe Thr His Tyr Gln Val Ser Ser Gly Trp Ile Thr Ser Met Arg Leu 
        35                  40                  45              

Thr Leu Ala Gly Ser Leu Val Leu Ile Trp Ser Ala Ile Gln Leu Lys 
    50                  55                  60                  

Ser Gln Val Leu Asp Ile Trp Arg Asp Lys Lys Asn Tyr Leu Pro Phe 
65                  70                  75                  80  

Leu Ala Tyr Ala Ile Leu Gly Ile Phe Ser Val Gln Tyr Phe Phe Tyr 
                85                  90                  95      

Leu Cys Val Glu Tyr Ser Asn Ala Thr Thr Ala Thr Ile Leu Gln Phe 
            100                 105                 110         

Ile Ser Pro Val Phe Ile Leu Phe Tyr Asn Arg Leu Val Tyr Gln Lys 
        115                 120                 125             

Arg Ala Ser Lys Ser Ala Val Phe Tyr Val Leu Val Ala Met Leu Gly 
    130                 135                 140                 

Val Cys Leu Met Ala Thr Lys Gly Asp Leu Ser Gln Leu Ser Met Thr 
145                 150                 155                 160 

Pro Leu Ala Leu Ile Thr Gly Leu Leu Ser Ala Met Gly Val Met Phe 
                165                 170                 175     

Asn Val Ile Leu Pro Gln Pro Phe Ala Lys Arg Tyr Gly Phe Val Pro 
            180                 185                 190         

Thr Val Gly Trp Gly Met Ile Leu Ala Gly Leu Phe Ser Asn Val Leu 
        195                 200                 205             

Ser Pro Val Tyr Gln Leu Ser Phe Thr Leu Asp Ile Trp Ser Ile Leu 
    210                 215                 220                 

Ile Cys Leu Ile Ile Ala Phe Phe Gly Thr Ala Phe Ala Phe Phe Ile 
225                 230                 235                 240 

Ser Met Lys Ala Val Ser Leu Val Ser Pro Leu Val Val Ala Val Ile 
                245                 250                 255     

Ser Ala Ser Glu Pro Leu Ser Ser Ala Leu Leu Ser Val Leu Phe Leu 
            260                 265                 270         

Gly Leu Val Val Asp Trp Ser Leu Leu Leu Ala Ile Ala Leu Ile Ile 
        275                 280                 285             

Leu Pro Met Ile Phe Leu Ser Ile Glu Glu Ala Lys Glu Ser Arg 
    290                 295                 300             

<210>   4381
<211>   2475
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4381
gtgaggaaat ccatgcaaaa tcaattaaat gaattaaaac gaaaaatgct ggaatttttc   60
cagcaaaaac aaaaaaataa aaaatcagct agacctggca agaaaggttc aagtaccaaa   120
aaatctaaaa ccttagataa gtcagtcatt ttcccagcta ttttactgag tataaaagcc   180
ttatttaact tactctttgt actcggtttt ctaggaggaa tgttgggagc tgggattgct   240
ttgggatacg gagtggcctt atttgacaag gttcgggtgc ctcagacaga agaattggtg   300
aatcaggtca aggacatctc ttctatttca gagattacct attcggacgg gacggtgatt   360
gcttccatag agagtgattt gttgcgcact tctatctcat ctgagcaaat ttcggaaaat   420
ctgaagaagg ctatcattgc gacagaagat gaacacttta aagaacataa gggtgtagta   480
cccaaggcgg tgattcgtgc gaccttgggg aaatttgtag gtttgggttc ctctagtggg   540
ggttcaacct tgacccagca actaattaaa cagcaggtgg ttggggatgc gccgaccttg   600
gctcgtaagg cggcagagat tgtggatgct cttgccttgg aacgcgccat gaataaagat   660
gagattttaa cgacctatct caatgtggct ccctttggcc gaaataataa gggacagaat   720
attgcagggg ctcggcaagc agctgaggga attttcggtg tagatgccag tcagttgact   780
gttcctcaag cagcattttt agcaggactt ccacagagtc ccattactta ctctccttat   840
gaaaatactg gggagttgaa gagtgatgaa gacctagaaa ttggcttaag acgggctaag   900
gcagttcttt acagtatgta tcgtacaggt gcattaagca aagacgagta ttctcagtac   960
aaggattatg accttaaaca ggacttttta ccatcgggca cggttacagg aatttcacga   1020
gactatttat actttacaac tttggcagaa gctcaagaac gtatgtatga ctatctagct   1080
cagagagaca atgtctccgc taaggagttg aaaaatgagg caactcagaa gttttatcga   1140
gatttggcag ccaaggaaat tgaaaatggt ggttataaga ttactactac catagatcag   1200
aaaattcatt ctgccatgca aagtgcggtt gctgattatg gctatctttt agacgatgga   1260
acaggtcgtg tagaagtagg gaatgtcttg atggataacc aaacaggtgc tattctaggc   1320
tttgtaggtg gtcgtaatta tcaagaaaat caaaataatc atgcctttga taccaaacgt   1380
tcgccagctt ctactaccaa gcccttgctg gcctacggta ttgctattga ccagggcttg   1440
atgggaagtg aaacgattct atctaactat ccaacaaact ttgctaatgg caatccgatt   1500
atgtatgcta atagcaaggg aacaggaatg atgaccttgg gagaagctct gaactattca   1560
tggaatatcc ctgcttactg gacctatcgt atgctccgtg aaaagggtgt tgatgtcaag   1620
ggttatatgg aaaagatggg ttacgagatt cctgagtacg gtattgagag cttgccaatg   1680
ggtggtggta ttgaagtcac agttgcccag cataccaatg gctatcagac cttagctaat   1740
aatggagttt atcatcagaa gcatgtgatt tcaaagattg aagcagcaga tggtagagtg   1800
gtgtatgagt atcaggataa accggttcaa gtctattcaa aagctactgc gacgattatg   1860
cagggattgc tacgagaagt tctatcctct cgtgtgacaa caaccttcaa gtctaacctg   1920
acttctttaa atcctactct ggctaatgca gattggattg ggaagactgg tacaaccaac   1980
caagacgaaa atatgtggct catgctttcg acacctagat taaccctagg tggctggatt   2040
gggcatgatg ataatcattc attgtcacgt agagcaggtt attctaataa ctctaattac   2100
atggctcatc tggtaaatgc gattcagcaa gcttccccaa gcatttgggg gaacgagcgc   2160
tttgctttag atcctagtgt agtgaaatcg gaagtcttga aatcaacagg tcaaaaacca   2220
gagaaggttt ctgttgaagg aaaagaagta gaggtcacag gttcgactgt taccagctat   2280
tgggctaata agtcaggagc gccagcgaca agttatcgct ttgctattgg cggaagtgat   2340
gcggattatc agaatgcttg gtctagtatt gtggggagtc taccaactcc atccagctcc   2400
agcagttcaa gtagtagttc tagcgatagc agtaactcaa gtactacacg accttcttct   2460
tcaagggcga gacga                                                    2475

<210>   4382
<211>   825
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   penicillin-binding protein 1B (pbp1B)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903950 (0.E+01)

<400>   4382
Met Arg Lys Ser Met Gln Asn Gln Leu Asn Glu Leu Lys Arg Lys Met 
1               5                   10                  15      

Leu Glu Phe Phe Gln Gln Lys Gln Lys Asn Lys Lys Ser Ala Arg Pro 
            20                  25                  30          

Gly Lys Lys Gly Ser Ser Thr Lys Lys Ser Lys Thr Leu Asp Lys Ser 
        35                  40                  45              

Val Ile Phe Pro Ala Ile Leu Leu Ser Ile Lys Ala Leu Phe Asn Leu 
    50                  55                  60                  

Leu Phe Val Leu Gly Phe Leu Gly Gly Met Leu Gly Ala Gly Ile Ala 
65                  70                  75                  80  

Leu Gly Tyr Gly Val Ala Leu Phe Asp Lys Val Arg Val Pro Gln Thr 
                85                  90                  95      

Glu Glu Leu Val Asn Gln Val Lys Asp Ile Ser Ser Ile Ser Glu Ile 
            100                 105                 110         

Thr Tyr Ser Asp Gly Thr Val Ile Ala Ser Ile Glu Ser Asp Leu Leu 
        115                 120                 125             

Arg Thr Ser Ile Ser Ser Glu Gln Ile Ser Glu Asn Leu Lys Lys Ala 
    130                 135                 140                 

Ile Ile Ala Thr Glu Asp Glu His Phe Lys Glu His Lys Gly Val Val 
145                 150                 155                 160 

Pro Lys Ala Val Ile Arg Ala Thr Leu Gly Lys Phe Val Gly Leu Gly 
                165                 170                 175     

Ser Ser Ser Gly Gly Ser Thr Leu Thr Gln Gln Leu Ile Lys Gln Gln 
            180                 185                 190         

Val Val Gly Asp Ala Pro Thr Leu Ala Arg Lys Ala Ala Glu Ile Val 
        195                 200                 205             

Asp Ala Leu Ala Leu Glu Arg Ala Met Asn Lys Asp Glu Ile Leu Thr 
    210                 215                 220                 

Thr Tyr Leu Asn Val Ala Pro Phe Gly Arg Asn Asn Lys Gly Gln Asn 
225                 230                 235                 240 

Ile Ala Gly Ala Arg Gln Ala Ala Glu Gly Ile Phe Gly Val Asp Ala 
                245                 250                 255     

Ser Gln Leu Thr Val Pro Gln Ala Ala Phe Leu Ala Gly Leu Pro Gln 
            260                 265                 270         

Ser Pro Ile Thr Tyr Ser Pro Tyr Glu Asn Thr Gly Glu Leu Lys Ser 
        275                 280                 285             

Asp Glu Asp Leu Glu Ile Gly Leu Arg Arg Ala Lys Ala Val Leu Tyr 
    290                 295                 300                 

Ser Met Tyr Arg Thr Gly Ala Leu Ser Lys Asp Glu Tyr Ser Gln Tyr 
305                 310                 315                 320 

Lys Asp Tyr Asp Leu Lys Gln Asp Phe Leu Pro Ser Gly Thr Val Thr 
                325                 330                 335     

Gly Ile Ser Arg Asp Tyr Leu Tyr Phe Thr Thr Leu Ala Glu Ala Gln 
            340                 345                 350         

Glu Arg Met Tyr Asp Tyr Leu Ala Gln Arg Asp Asn Val Ser Ala Lys 
        355                 360                 365             

Glu Leu Lys Asn Glu Ala Thr Gln Lys Phe Tyr Arg Asp Leu Ala Ala 
    370                 375                 380                 

Lys Glu Ile Glu Asn Gly Gly Tyr Lys Ile Thr Thr Thr Ile Asp Gln 
385                 390                 395                 400 

Lys Ile His Ser Ala Met Gln Ser Ala Val Ala Asp Tyr Gly Tyr Leu 
                405                 410                 415     

Leu Asp Asp Gly Thr Gly Arg Val Glu Val Gly Asn Val Leu Met Asp 
            420                 425                 430         

Asn Gln Thr Gly Ala Ile Leu Gly Phe Val Gly Gly Arg Asn Tyr Gln 
        435                 440                 445             

Glu Asn Gln Asn Asn His Ala Phe Asp Thr Lys Arg Ser Pro Ala Ser 
    450                 455                 460                 

Thr Thr Lys Pro Leu Leu Ala Tyr Gly Ile Ala Ile Asp Gln Gly Leu 
465                 470                 475                 480 

Met Gly Ser Glu Thr Ile Leu Ser Asn Tyr Pro Thr Asn Phe Ala Asn 
                485                 490                 495     

Gly Asn Pro Ile Met Tyr Ala Asn Ser Lys Gly Thr Gly Met Met Thr 
            500                 505                 510         

Leu Gly Glu Ala Leu Asn Tyr Ser Trp Asn Ile Pro Ala Tyr Trp Thr 
        515                 520                 525             

Tyr Arg Met Leu Arg Glu Lys Gly Val Asp Val Lys Gly Tyr Met Glu 
    530                 535                 540                 

Lys Met Gly Tyr Glu Ile Pro Glu Tyr Gly Ile Glu Ser Leu Pro Met 
545                 550                 555                 560 

Gly Gly Gly Ile Glu Val Thr Val Ala Gln His Thr Asn Gly Tyr Gln 
                565                 570                 575     

Thr Leu Ala Asn Asn Gly Val Tyr His Gln Lys His Val Ile Ser Lys 
            580                 585                 590         

Ile Glu Ala Ala Asp Gly Arg Val Val Tyr Glu Tyr Gln Asp Lys Pro 
        595                 600                 605             

Val Gln Val Tyr Ser Lys Ala Thr Ala Thr Ile Met Gln Gly Leu Leu 
    610                 615                 620                 

Arg Glu Val Leu Ser Ser Arg Val Thr Thr Thr Phe Lys Ser Asn Leu 
625                 630                 635                 640 

Thr Ser Leu Asn Pro Thr Leu Ala Asn Ala Asp Trp Ile Gly Lys Thr 
                645                 650                 655     

Gly Thr Thr Asn Gln Asp Glu Asn Met Trp Leu Met Leu Ser Thr Pro 
            660                 665                 670         

Arg Leu Thr Leu Gly Gly Trp Ile Gly His Asp Asp Asn His Ser Leu 
        675                 680                 685             

Ser Arg Arg Ala Gly Tyr Ser Asn Asn Ser Asn Tyr Met Ala His Leu 
    690                 695                 700                 

Val Asn Ala Ile Gln Gln Ala Ser Pro Ser Ile Trp Gly Asn Glu Arg 
705                 710                 715                 720 

Phe Ala Leu Asp Pro Ser Val Val Lys Ser Glu Val Leu Lys Ser Thr 
                725                 730                 735     

Gly Gln Lys Pro Glu Lys Val Ser Val Glu Gly Lys Glu Val Glu Val 
            740                 745                 750         

Thr Gly Ser Thr Val Thr Ser Tyr Trp Ala Asn Lys Ser Gly Ala Pro 
        755                 760                 765             

Ala Thr Ser Tyr Arg Phe Ala Ile Gly Gly Ser Asp Ala Asp Tyr Gln 
    770                 775                 780                 

Asn Ala Trp Ser Ser Ile Val Gly Ser Leu Pro Thr Pro Ser Ser Ser 
785                 790                 795                 800 

Ser Ser Ser Ser Ser Ser Ser Ser Asp Ser Ser Asn Ser Ser Thr Thr 
                805                 810                 815     

Arg Pro Ser Ser Ser Arg Ala Arg Arg 
            820                 825 

<210>   4383
<211>   1254
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4383
atgcacattt ttgatgagct aaaagagcgt ggtttgatat ttcaaacgac tgatgaagaa   60
gctttgcgta aagccctaga agaaggtcaa gtttcttatt atactggcta cgatccaact   120
gctgacagcc ttcacctagg ccaccttgtc gcaatcttga caagtcgtcg cttgcaacta   180
gcaggtcaca aaccttatgc gctcgttggc ggtgctacag gtctcatcgg agatccgtcc   240
ttcaaagatg ctgaacgtag tctccaaaca aaagacacag tagatggctg ggtcaagtct   300
atccaaggac aactttctcg ttttcttgac tttgaaaatg gcgaaaacaa ggctgtcatg   360
gtcaacaact acgactggtt tggcagcatc agcttcattg acttcctccg tgatattgga   420
aaatacttca cggtcaacta catgatgagt aaggaatctg ttaaaaaacg gatcgaaaca   480
ggaatttctt acactgagtt cgcttaccaa atcatgcaag ggtatgactt cttcgtcctt   540
aaccaagacc ataatgtcac tcttcaaatc ggtggttctg accagtgggg aaatatgaca   600
gctggtaccg aattgcttcg tcgtaaggcg gacaagactg gtcacgttat cactgttcca   660
ctaatcacag atgcaactgg taagaaattt ggtaaatcag aaggaaatgc cgtctggctc   720
aatcccgaaa agacttctcc atacgaaatg taccaattct ggatgaacgt gatggacgct   780
gacgctgttc gcttcttgaa aatctttact ttcttgtcac ttgatgagat tgaagatatt   840
cgtaaacaat ttgaagcagc gccacacgaa cgcttggctc aaaaagtctt ggctcgtgaa   900
gttgttacac ttgttcacgg agaagaagcc tacaaagaag cacttaacat cactgagcaa   960
ctctttgcag gaaacatcaa aaacctttct gtcaaagagc tcaaacaagg acttcgtggt   1020
gtgcccaact accaagtaca ggcagacgaa aacaacaata tcgtggaact gctcgtctca   1080
tctggtatag ttaactcaaa acgccaagcc cgtgaagacg tccaaaacgg agccatctac   1140
gtaaacggcg accgcatcca agagcttgac tatgtcttga gtgacgctga taagttagag   1200
aatgaactga ctgttatccg tcgtgggaag aaaaaatact ttgtattgac ttac         1254

<210>   4384
<211>   418
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tyrosyl-tRNA synthetase (tyrS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903951 (0.E+01)

<400>   4384
Met His Ile Phe Asp Glu Leu Lys Glu Arg Gly Leu Ile Phe Gln Thr 
1               5                   10                  15      

Thr Asp Glu Glu Ala Leu Arg Lys Ala Leu Glu Glu Gly Gln Val Ser 
            20                  25                  30          

Tyr Tyr Thr Gly Tyr Asp Pro Thr Ala Asp Ser Leu His Leu Gly His 
        35                  40                  45              

Leu Val Ala Ile Leu Thr Ser Arg Arg Leu Gln Leu Ala Gly His Lys 

    50                  55                  60                  

Pro Tyr Ala Leu Val Gly Gly Ala Thr Gly Leu Ile Gly Asp Pro Ser 
65                  70                  75                  80  

Phe Lys Asp Ala Glu Arg Ser Leu Gln Thr Lys Asp Thr Val Asp Gly 
                85                  90                  95      

Trp Val Lys Ser Ile Gln Gly Gln Leu Ser Arg Phe Leu Asp Phe Glu 
            100                 105                 110         

Asn Gly Glu Asn Lys Ala Val Met Val Asn Asn Tyr Asp Trp Phe Gly 
        115                 120                 125             

Ser Ile Ser Phe Ile Asp Phe Leu Arg Asp Ile Gly Lys Tyr Phe Thr 
    130                 135                 140                 

Val Asn Tyr Met Met Ser Lys Glu Ser Val Lys Lys Arg Ile Glu Thr 
145                 150                 155                 160 

Gly Ile Ser Tyr Thr Glu Phe Ala Tyr Gln Ile Met Gln Gly Tyr Asp 
                165                 170                 175     

Phe Phe Val Leu Asn Gln Asp His Asn Val Thr Leu Gln Ile Gly Gly 
            180                 185                 190         

Ser Asp Gln Trp Gly Asn Met Thr Ala Gly Thr Glu Leu Leu Arg Arg 
        195                 200                 205             

Lys Ala Asp Lys Thr Gly His Val Ile Thr Val Pro Leu Ile Thr Asp 
    210                 215                 220                 

Ala Thr Gly Lys Lys Phe Gly Lys Ser Glu Gly Asn Ala Val Trp Leu 
225                 230                 235                 240 

Asn Pro Glu Lys Thr Ser Pro Tyr Glu Met Tyr Gln Phe Trp Met Asn 
                245                 250                 255     

Val Met Asp Ala Asp Ala Val Arg Phe Leu Lys Ile Phe Thr Phe Leu 
            260                 265                 270         

Ser Leu Asp Glu Ile Glu Asp Ile Arg Lys Gln Phe Glu Ala Ala Pro 
        275                 280                 285             

His Glu Arg Leu Ala Gln Lys Val Leu Ala Arg Glu Val Val Thr Leu 
    290                 295                 300                 

Val His Gly Glu Glu Ala Tyr Lys Glu Ala Leu Asn Ile Thr Glu Gln 
305                 310                 315                 320 

Leu Phe Ala Gly Asn Ile Lys Asn Leu Ser Val Lys Glu Leu Lys Gln 
                325                 330                 335     

Gly Leu Arg Gly Val Pro Asn Tyr Gln Val Gln Ala Asp Glu Asn Asn 
            340                 345                 350         

Asn Ile Val Glu Leu Leu Val Ser Ser Gly Ile Val Asn Ser Lys Arg 
        355                 360                 365             

Gln Ala Arg Glu Asp Val Gln Asn Gly Ala Ile Tyr Val Asn Gly Asp 
    370                 375                 380                 

Arg Ile Gln Glu Leu Asp Tyr Val Leu Ser Asp Ala Asp Lys Leu Glu 
385                 390                 395                 400 

Asn Glu Leu Thr Val Ile Arg Arg Gly Lys Lys Lys Tyr Phe Val Leu 
                405                 410                 415     

Thr Tyr 
        

<210>   4385
<211>   2070
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4385
gtgaataata tgtcttttaa agtgctacat agaggatacc aacatatccg actatcatct   60
tctttttcac ttaccttgga tattcaagac tatcttcgtt ccttggcgag agatgaaaag   120
gggattgagt ctatccagtt ttacatggat caacagcact ttactctacg cataaaagaa   180
ggcttttctg tattagataa tgcagaagcc tttttaaaaa gaattgataa agggaaagtt   240
tctgagttga tgactcttcc cattcgtaga gaagagagtg cttattctat tgtttcaggt   300
gcagcggtta agcgtgtact ttttcgtagt tttgtgccgt atcctattcg ctatatatgg   360
acttgttatc aggctttggg ttatattaga gaagcctatc aaacactagc gcgtaaggaa   420
ctaacgatgg aagtcttgga ctgttcggct attttattgt ctttgtttat gaaccaatcc   480
aagacagcta gcaatatcat gtttatgctt gatttgggga atcatttaga tcagtggtcc   540
ttgaaaaaaa ctgcaacaga tttagaacag agtcttcttg caaaagagag cgatgtattc   600
ctagtacagg gcgatacggt tgttagtatc aagagttccg atgttcaaat aggagatgtc   660
ttgatcttat ctcaaggaaa tgaaattctg tttgatggac aagtagtttc aggtttaggt   720
atggtcaacg aaagttcctt gacaggagag agttttccag ttgaaaaaag agagtctgat   780
ttggtttgtg caaatacagt attagaaact ggagagttac gcattcgtgt aacagataat   840
cagatgaaca gccgtatttt acagctgatt gagttgatga agaaatctga agaaaacaag   900
aaaacgaaac aacgctattt catcaagatg gcggataaag tcgtcaaata taatttcttg   960
ggggctgggc tgacttacct attgacaggt tctttttcta aggctatttc tttcctattg   1020
gtcgatttct cctgcgcttt gaaaatctct actcctgtag cttatttgac agttatcaag   1080
gaagggttga accgtgaaat ggtgattaag gatggagatg ttctggagaa atatctggaa   1140
gttgatactt tcttgtttga taagacagga acaatcacaa ctagttatcc tatagttgaa   1200
aaggtgttac cttttggaga ctatagtgag gaagatattc tcagaatcag tgcctgtctt   1260
gaggaacaca tttatcatcc tattgctaat gccatcgtca agcaagctga gatagaggga   1320
attgaacatg aggaaatgca tgggaaactc caatatatcg caagcaaggg gatcaaatct   1380
catatagatg gccaaccagt tcttattggg aattatgtct tgatgcagga tgagcagatt   1440
catatcagtt cagaacaaaa tgctttaatt gaagagtaca agagtcacta caatctctta   1500
ttcttggctt atcaaaatga attgattgga atgttctgca ttcatactcc tttgagaaaa   1560
gaagcaaaaa cagccttgga taaacttaag gcacagggga aaaaattgat tctggcaaca   1620
ggagacacct tgattaggac agaggaatta gtcaaagatt tgccctttga tcaggtctat   1680
acagacttga aacctgatgg gaaatttgag ttagtagaga aactgcagaa agcaggtcac   1740
actattttga tggttggaga tggattgaat gactcagcgg ctttaactct atcagatatc   1800
ggtgtggtga tgaatgagag tgcagatatt tctaagcaga tgagtgatat cttattgtta   1860
gataatcgtt tggatttctt ccaagagttg gattcgttat catcatcttt gcaaacactc   1920
atcaagaaaa atattcagga taccgttgtc gtaaatagta gtttgattgg ctttggctta   1980
tttaattggt tcagtccttc aaatctctct atcttacata atctaacaac cttgcgcatt   2040
gtcctgcgta gcctgtctat taaaaataga                                    2070

<210>   4386
<211>   690
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cation-transporting ATPase, EI-E2 family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903952 (0.E+01)

<400>   4386
Met Asn Asn Met Ser Phe Lys Val Leu His Arg Gly Tyr Gln His Ile 
1               5                   10                  15      

Arg Leu Ser Ser Ser Phe Ser Leu Thr Leu Asp Ile Gln Asp Tyr Leu 
            20                  25                  30          

Arg Ser Leu Ala Arg Asp Glu Lys Gly Ile Glu Ser Ile Gln Phe Tyr 
        35                  40                  45              

Met Asp Gln Gln His Phe Thr Leu Arg Ile Lys Glu Gly Phe Ser Val 
    50                  55                  60                  

Leu Asp Asn Ala Glu Ala Phe Leu Lys Arg Ile Asp Lys Gly Lys Val 
65                  70                  75                  80  

Ser Glu Leu Met Thr Leu Pro Ile Arg Arg Glu Glu Ser Ala Tyr Ser 
                85                  90                  95      

Ile Val Ser Gly Ala Ala Val Lys Arg Val Leu Phe Arg Ser Phe Val 
            100                 105                 110         

Pro Tyr Pro Ile Arg Tyr Ile Trp Thr Cys Tyr Gln Ala Leu Gly Tyr 
        115                 120                 125             

Ile Arg Glu Ala Tyr Gln Thr Leu Ala Arg Lys Glu Leu Thr Met Glu 
    130                 135                 140                 

Val Leu Asp Cys Ser Ala Ile Leu Leu Ser Leu Phe Met Asn Gln Ser 
145                 150                 155                 160 

Lys Thr Ala Ser Asn Ile Met Phe Met Leu Asp Leu Gly Asn His Leu 
                165                 170                 175     

Asp Gln Trp Ser Leu Lys Lys Thr Ala Thr Asp Leu Glu Gln Ser Leu 
            180                 185                 190         

Leu Ala Lys Glu Ser Asp Val Phe Leu Val Gln Gly Asp Thr Val Val 
        195                 200                 205             

Ser Ile Lys Ser Ser Asp Val Gln Ile Gly Asp Val Leu Ile Leu Ser 
    210                 215                 220                 

Gln Gly Asn Glu Ile Leu Phe Asp Gly Gln Val Val Ser Gly Leu Gly 
225                 230                 235                 240 

Met Val Asn Glu Ser Ser Leu Thr Gly Glu Ser Phe Pro Val Glu Lys 
                245                 250                 255     

Arg Glu Ser Asp Leu Val Cys Ala Asn Thr Val Leu Glu Thr Gly Glu 
            260                 265                 270         

Leu Arg Ile Arg Val Thr Asp Asn Gln Met Asn Ser Arg Ile Leu Gln 
        275                 280                 285             

Leu Ile Glu Leu Met Lys Lys Ser Glu Glu Asn Lys Lys Thr Lys Gln 
    290                 295                 300                 

Arg Tyr Phe Ile Lys Met Ala Asp Lys Val Val Lys Tyr Asn Phe Leu 
305                 310                 315                 320 

Gly Ala Gly Leu Thr Tyr Leu Leu Thr Gly Ser Phe Ser Lys Ala Ile 
                325                 330                 335     

Ser Phe Leu Leu Val Asp Phe Ser Cys Ala Leu Lys Ile Ser Thr Pro 
            340                 345                 350         

Val Ala Tyr Leu Thr Val Ile Lys Glu Gly Leu Asn Arg Glu Met Val 
        355                 360                 365             

Ile Lys Asp Gly Asp Val Leu Glu Lys Tyr Leu Glu Val Asp Thr Phe 
    370                 375                 380                 

Leu Phe Asp Lys Thr Gly Thr Ile Thr Thr Ser Tyr Pro Ile Val Glu 
385                 390                 395                 400 

Lys Val Leu Pro Phe Gly Asp Tyr Ser Glu Glu Asp Ile Leu Arg Ile 
                405                 410                 415     

Ser Ala Cys Leu Glu Glu His Ile Tyr His Pro Ile Ala Asn Ala Ile 
            420                 425                 430         

Val Lys Gln Ala Glu Ile Glu Gly Ile Glu His Glu Glu Met His Gly 
        435                 440                 445             

Lys Leu Gln Tyr Ile Ala Ser Lys Gly Ile Lys Ser His Ile Asp Gly 
    450                 455                 460                 

Gln Pro Val Leu Ile Gly Asn Tyr Val Leu Met Gln Asp Glu Gln Ile 
465                 470                 475                 480 

His Ile Ser Ser Glu Gln Asn Ala Leu Ile Glu Glu Tyr Lys Ser His 
                485                 490                 495     

Tyr Asn Leu Leu Phe Leu Ala Tyr Gln Asn Glu Leu Ile Gly Met Phe 
            500                 505                 510         

Cys Ile His Thr Pro Leu Arg Lys Glu Ala Lys Thr Ala Leu Asp Lys 
        515                 520                 525             

Leu Lys Ala Gln Gly Lys Lys Leu Ile Leu Ala Thr Gly Asp Thr Leu 
    530                 535                 540                 

Ile Arg Thr Glu Glu Leu Val Lys Asp Leu Pro Phe Asp Gln Val Tyr 
545                 550                 555                 560 

Thr Asp Leu Lys Pro Asp Gly Lys Phe Glu Leu Val Glu Lys Leu Gln 
                565                 570                 575     

Lys Ala Gly His Thr Ile Leu Met Val Gly Asp Gly Leu Asn Asp Ser 
            580                 585                 590         

Ala Ala Leu Thr Leu Ser Asp Ile Gly Val Val Met Asn Glu Ser Ala 
        595                 600                 605             

Asp Ile Ser Lys Gln Met Ser Asp Ile Leu Leu Leu Asp Asn Arg Leu 
    610                 615                 620                 

Asp Phe Phe Gln Glu Leu Asp Ser Leu Ser Ser Ser Leu Gln Thr Leu 
625                 630                 635                 640 

Ile Lys Lys Asn Ile Gln Asp Thr Val Val Val Asn Ser Ser Leu Ile 
                645                 650                 655     

Gly Phe Gly Leu Phe Asn Trp Phe Ser Pro Ser Asn Leu Ser Ile Leu 
            660                 665                 670         

His Asn Leu Thr Thr Leu Arg Ile Val Leu Arg Ser Leu Ser Ile Lys 
        675                 680                 685             

Asn Arg 
    690 

<210>   4387
<211>   309
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4387
ttgctatata ataatgataa ggaggaaata agtatgttaa aagaagtatt aaccgttgca   60
aaagttgcga aaaaatcttc attatttttg ggtggtgtcg catttggtac ccttggtttg   120
aaaatcttag caagtaagga agctaaaaaa ggttattcta aagctttggc taaggcttac   180
aagttgaaag acgagctaga tgcatctgtt tctgttgtga agcaacatgg agacgatgtc   240
ttgcaagatg ccaaatattt gtacgagcaa gagaaaaaag aagagcaatt agatagcctt   300
ataggtgaa                                                           309

<210>   4388
<211>   103
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903953 (7.E-53)

<400>   4388
Met Leu Tyr Asn Asn Asp Lys Glu Glu Ile Ser Met Leu Lys Glu Val 
1               5                   10                  15      

Leu Thr Val Ala Lys Val Ala Lys Lys Ser Ser Leu Phe Leu Gly Gly 
            20                  25                  30          

Val Ala Phe Gly Thr Leu Gly Leu Lys Ile Leu Ala Ser Lys Glu Ala 
        35                  40                  45              

Lys Lys Gly Tyr Ser Lys Ala Leu Ala Lys Ala Tyr Lys Leu Lys Asp 
    50                  55                  60                  

Glu Leu Asp Ala Ser Val Ser Val Val Lys Gln His Gly Asp Asp Val 
65                  70                  75                  80  

Leu Gln Asp Ala Lys Tyr Leu Tyr Glu Gln Glu Lys Lys Glu Glu Gln 
                85                  90                  95      

Leu Asp Ser Leu Ile Gly Glu 
            100             

<210>   4389
<211>   845
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4389
atgaatacaa atctcaagcc caaacttcag cgttttgctt ctgcgactgc ctttgcctgt   60
cctatctgtc aagaaaatct gactctgtta gagactaatt tcaagtgctg caaccgtcat   120
tcttttgact tggcgaaatt tggctatgtc aatctagtcc ctcaaatcaa gcaatctgct   180
aactacgaca aggaaaattt tcaaaaccgt caacaaatcc tagaagccgg cttttaccaa   240
gctatcttag atgctgtatc tgacttgctt gcaagctcaa aaactaccac aacaattttg   300
gatatcggtt gtggtgaagg attctattct cgcaaactac aagaaagtca ctctgaaaaa   360
actttctatg cctttgacat ctccaaagat tcagtccaaa tcgctgctaa aagtgaaccc   420
aactgggcag tcaattggtt cgttggcgac ttggcacgac ttcctataaa gacgctaaca   480
tggatattct gcttgatatc ttctcacctg ccaactatgg agaatttcgt cgcgttttat   540
ccaaagacgg tatcttgata aaggttatcc caactgaaaa tcacctcaaa gaaatccgtc   600
aaagagtaca ggaccagctg acaaacaagg agtattctaa ccaagatatc aaggagcatt   660
tccaggaaca ctttaccatc ctatctagtc aaactgcctc tctgactaag actatcacag   720
cagaacaact ccaagcccta ctcagtatga ctcctctcct ctttcacgtt gaccagagca   780
aaattgactg gagcaaactg acagagatta ccatcgaagc agagattttg gttgggaaag   840
cattc                                                               845


<210>   4390
<400>   4390
000

<210>   4391
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4391
ttgccgtacg tatggttact gacttcgtca gtttcatcta caacctcaaa accatgtttt   60
gagctgactt cgtcagtttt atctgcaacc tcaaagctgt actttgagca acctacggct   120
agtttactct ttgattttca t                                             141

<210>   4392
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>

<223>   box element

<400>   4392
Met Pro Tyr Val Trp Leu Leu Thr Ser Ser Val Ser Ser Thr Thr Ser 
1               5                   10                  15      

Lys Pro Cys Phe Glu Leu Thr Ser Ser Val Leu Ser Ala Thr Ser Lys 
            20                  25                  30          

Leu Tyr Phe Glu Gln Pro Thr Ala Ser Leu Leu Phe Asp Phe His 
        35                  40                  45          

<210>   4393
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4393
atgttaaaaa aatatttttc aaaatataaa tggacggatt tattttggat tttatttgtt   60
attttgacct gcctctatat tggtaaccat gatttgttta ctctcaatca tcaagaattc   120
tcttttcgtg gtagcgtttg gggtctggta ctggccttat atcacttact attcattgat   180
aagtttgtta tatcgaatcg aaaa                                          204

<210>   4394
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (23S rRNA m1G745)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903954 (e-160)

<400>   4394
Met Leu Lys Lys Tyr Phe Ser Lys Tyr Lys Trp Thr Asp Leu Phe Trp 
1               5                   10                  15      

Ile Leu Phe Val Ile Leu Thr Cys Leu Tyr Ile Gly Asn His Asp Leu 
            20                  25                  30          

Phe Thr Leu Asn His Gln Glu Phe Ser Phe Arg Gly Ser Val Trp Gly 
        35                  40                  45              

Leu Val Leu Ala Leu Tyr His Leu Leu Phe Ile Asp Lys Phe Val Ile 
    50                  55                  60                  

Ser Asn Arg Lys 
65              

<210>   4395
<211>   570
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4395
atgaacaaat taatgaaatt tatttcggtt tttttgacgt caattgtgtt aattgtatca   60
gcgattccaa gtgtttcagc tgtatacgct tctgaacaag tatcacaaat tgaaacaaat   120
atggaacttc aacctgtcac ttctctaaca gaagaacaaa tcaatacact tgcaaacgaa   180
atccaatctt ttcatccaga cgtctcacaa caatggatca aagaagtaat taaccgacaa   240
ttacaaggcg attatacaat cccacctaca tactctccat ttagagcagt ttggcaaggt   300
attacagtta atcaaatggg tgctctatta gatactgcaa tagctttagc attaggagga   360
actactgcag gccttgcaaa tctaattaaa gtaaaaggaa aacatgcagc aaaaagtgct   420
attcgttcag caatttctag atatctaggt agttggtttg taaatgatgt tgctttagaa   480
ttcgctatga atttattatc accggggact tatttagcac aattatggga taaaaatgat   540
gccattccta acaacggaag gattaacttt                                    570

<210>   4396
<211>   190
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903956 (e-103)

<400>   4396
Met Asn Lys Leu Met Lys Phe Ile Ser Val Phe Leu Thr Ser Ile Val 
1               5                   10                  15      

Leu Ile Val Ser Ala Ile Pro Ser Val Ser Ala Val Tyr Ala Ser Glu 
            20                  25                  30          

Gln Val Ser Gln Ile Glu Thr Asn Met Glu Leu Gln Pro Val Thr Ser 
        35                  40                  45              

Leu Thr Glu Glu Gln Ile Asn Thr Leu Ala Asn Glu Ile Gln Ser Phe 
    50                  55                  60                  

His Pro Asp Val Ser Gln Gln Trp Ile Lys Glu Val Ile Asn Arg Gln 
65                  70                  75                  80  

Leu Gln Gly Asp Tyr Thr Ile Pro Pro Thr Tyr Ser Pro Phe Arg Ala 
                85                  90                  95      

Val Trp Gln Gly Ile Thr Val Asn Gln Met Gly Ala Leu Leu Asp Thr 
            100                 105                 110         

Ala Ile Ala Leu Ala Leu Gly Gly Thr Thr Ala Gly Leu Ala Asn Leu 
        115                 120                 125             

Ile Lys Val Lys Gly Lys His Ala Ala Lys Ser Ala Ile Arg Ser Ala 
    130                 135                 140                 

Ile Ser Arg Tyr Leu Gly Ser Trp Phe Val Asn Asp Val Ala Leu Glu 
145                 150                 155                 160 

Phe Ala Met Asn Leu Leu Ser Pro Gly Thr Tyr Leu Ala Gln Leu Trp 
                165                 170                 175     

Asp Lys Asn Asp Ala Ile Pro Asn Asn Gly Arg Ile Asn Phe 
            180                 185                 190 

<210>   4397
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4397
atgaaaatca aagagcaaac taggaagcta gccgcagttg ctcaaagcac tgctttgagg   60
ttgcagataa agctgacgtg gtttgaagag attttcgaag agtat                   105

<210>   4398
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4398
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Val Ala Gln Ser 
1               5                   10                  15      

Thr Ala Leu Arg Leu Gln Ile Lys Leu Thr Trp Phe Glu Glu Ile Phe 
            20                  25                  30          

Glu Glu Tyr 
        35  

<210>   4399
<211>   2256
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4399
atgttatcac tacaagaatt tgtacaaaat cgttacaata aaaccattgc agaatgtagc   60
aatgaagagc tttaccttgc tcttcttaac tacagcaagc ttgcaagcag ccaaaaacca   120
gtcaacactg gtaagaaaaa agtttactac atctcagctg agttcttgat tggtaaactc   180
ttgtcaaaca acttgattaa ccttggtctt tacgacgatg ttaaaaaaga acttgcagct   240
gcaggtaaag acttgatcga agttgaagaa gttgaattgg aaccatctct tggtaatggt   300
ggtttgggac gtttggctgc ctgctttatc gactcaattg ctactcttgg tttgaatggt   360
gacggtgttg gtcttaacta ccactttggt cttttccaac aagttcttaa aaacaaccaa   420
caagaaacaa ttccaaatgc atggttgaca gagcaaaact ggttggttcg ctcaagccgt   480
agctaccaag taccatttgc agactttact ttgacatcaa ctctttacga tattgatgtt   540
actggttatg aaacagcgac taaaaaccgc ttgcgtttgt ttgacttgga ttcagttgat   600
tcttctatta ttaaagatgg tatcaacttt gacaagacag atatcgctcg caacttaact   660
ctcttccttt acccagatga tagtgaccgt caaggtgaat tgctccgtat cttccaacaa   720
tacttcatgg tttcaaacgg tgcgcaattg atcatcgacg aagcaatcga aaaaggaagc   780
aacttgcatg accttgctga ctacgcagtt gtccaaatca acgatactca cccatcaatg   840
gtgattcctg aattgattcg tcttttgact gcacgtggta tcgatcttga cgaagcaatc   900
tcaattgttc gtagcatgac tgcctacact aaccacacaa tccttgctga agcgcttgaa   960
aaatggcctc ttgaattctt gcaagaagtg gttcctcact tggtaccaat catcgaagaa   1020
ttggaccgtc gtgtgaaggc agagtacaaa gatccagctg ttcaaatcat cgatgagagc   1080
ggacgtgttc acatggctca catggatatc cactacggat acagtgttaa cggggttgca   1140
gcactccata ctgaaatctt gaaaaattct gagttgaaag ccttctacga cctttaccca   1200
gaaaagttca acaacaaaac aaacggtatc actttccgtc gttggcttat gcatgctaac   1260
ccaagattgt ctcactactt ggatgagatt cttggagatg gttggcacca tgaagcagat   1320
gagcttgaaa aacttttgtc ttatgaagac aaagcagttg tcaaagaaaa attggaaagc   1380
atcaaggctc acaacaaacg taaattggct cgtcacttga aagaacacca aggtgtggaa   1440
atcaatccaa attctatctt tgatatccaa atcaaacgtc ttcacgagta caaacgccaa   1500
caaatgaacg ctttgtacgt gatccacaaa taccttgaca tcaaagctgg taacatccct   1560
gctcgtccaa tcacaatctt ctttggtggt aaagcagctc cagcctacac aatcgctcaa   1620
gacattatcc atttaatcct ttgcatgtca gaagttattg ctaacgatcc agcagtagct   1680
ccacacttgc aagtagttat ggttgaaaac tacaacgtta ctgcagcaag tttccttatc   1740
ccagcatgtg atatctcaga acaaatctca cttgcttcta aagaagcttc aggtactggt   1800
aacatgaaat tcatgttgaa cggagctttg acacttggta ctatggacgg tgctaacgtg   1860
gaaatcgctg agttggttgg agaagaaaac atctacatct tcggtgaaga ttcagaaact   1920
gttatcgacc tttacgcaaa agcagcttac aaatcaagcg aattctacgc tcgtgaagct   1980
atcaaaccat tggttgactt catcgttagt gatgcagttc ttgcagctgg aaacaaagag   2040
cgcttggaac gtttttacaa tgaattgatc aacaaagact ggttcatgac tcttcttgat   2100
ttggaagact acatcaaagt caaagagcaa atgcttgctg actacgaaga ccgtgacgca   2160
tggttggata aagtcatcgt taacatttct aaagcaggat tcttctcatc tgaccgtaca   2220
atcgctcagt ataacgaaga catctggcac ttgaac                             2256

<210>   4400
<211>   752
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycogen phosphorylase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903957 (0.E+01)

<400>   4400
Met Leu Ser Leu Gln Glu Phe Val Gln Asn Arg Tyr Asn Lys Thr Ile 
1               5                   10                  15      

Ala Glu Cys Ser Asn Glu Glu Leu Tyr Leu Ala Leu Leu Asn Tyr Ser 
            20                  25                  30          

Lys Leu Ala Ser Ser Gln Lys Pro Val Asn Thr Gly Lys Lys Lys Val 
        35                  40                  45              

Tyr Tyr Ile Ser Ala Glu Phe Leu Ile Gly Lys Leu Leu Ser Asn Asn 
    50                  55                  60                  

Leu Ile Asn Leu Gly Leu Tyr Asp Asp Val Lys Lys Glu Leu Ala Ala 
65                  70                  75                  80  

Ala Gly Lys Asp Leu Ile Glu Val Glu Glu Val Glu Leu Glu Pro Ser 
                85                  90                  95      

Leu Gly Asn Gly Gly Leu Gly Arg Leu Ala Ala Cys Phe Ile Asp Ser 
            100                 105                 110         

Ile Ala Thr Leu Gly Leu Asn Gly Asp Gly Val Gly Leu Asn Tyr His 
        115                 120                 125             

Phe Gly Leu Phe Gln Gln Val Leu Lys Asn Asn Gln Gln Glu Thr Ile 
    130                 135                 140                 

Pro Asn Ala Trp Leu Thr Glu Gln Asn Trp Leu Val Arg Ser Ser Arg 
145                 150                 155                 160 

Ser Tyr Gln Val Pro Phe Ala Asp Phe Thr Leu Thr Ser Thr Leu Tyr 
                165                 170                 175     

Asp Ile Asp Val Thr Gly Tyr Glu Thr Ala Thr Lys Asn Arg Leu Arg 
            180                 185                 190         

Leu Phe Asp Leu Asp Ser Val Asp Ser Ser Ile Ile Lys Asp Gly Ile 
        195                 200                 205             

Asn Phe Asp Lys Thr Asp Ile Ala Arg Asn Leu Thr Leu Phe Leu Tyr 
    210                 215                 220                 

Pro Asp Asp Ser Asp Arg Gln Gly Glu Leu Leu Arg Ile Phe Gln Gln 
225                 230                 235                 240 

Tyr Phe Met Val Ser Asn Gly Ala Gln Leu Ile Ile Asp Glu Ala Ile 
                245                 250                 255     

Glu Lys Gly Ser Asn Leu His Asp Leu Ala Asp Tyr Ala Val Val Gln 
            260                 265                 270         

Ile Asn Asp Thr His Pro Ser Met Val Ile Pro Glu Leu Ile Arg Leu 
        275                 280                 285             

Leu Thr Ala Arg Gly Ile Asp Leu Asp Glu Ala Ile Ser Ile Val Arg 
    290                 295                 300                 

Ser Met Thr Ala Tyr Thr Asn His Thr Ile Leu Ala Glu Ala Leu Glu 
305                 310                 315                 320 

Lys Trp Pro Leu Glu Phe Leu Gln Glu Val Val Pro His Leu Val Pro 
                325                 330                 335     

Ile Ile Glu Glu Leu Asp Arg Arg Val Lys Ala Glu Tyr Lys Asp Pro 
            340                 345                 350         

Ala Val Gln Ile Ile Asp Glu Ser Gly Arg Val His Met Ala His Met 
        355                 360                 365             

Asp Ile His Tyr Gly Tyr Ser Val Asn Gly Val Ala Ala Leu His Thr 
    370                 375                 380                 

Glu Ile Leu Lys Asn Ser Glu Leu Lys Ala Phe Tyr Asp Leu Tyr Pro 
385                 390                 395                 400 

Glu Lys Phe Asn Asn Lys Thr Asn Gly Ile Thr Phe Arg Arg Trp Leu 
                405                 410                 415     

Met His Ala Asn Pro Arg Leu Ser His Tyr Leu Asp Glu Ile Leu Gly 
            420                 425                 430         

Asp Gly Trp His His Glu Ala Asp Glu Leu Glu Lys Leu Leu Ser Tyr 
        435                 440                 445             

Glu Asp Lys Ala Val Val Lys Glu Lys Leu Glu Ser Ile Lys Ala His 
    450                 455                 460                 

Asn Lys Arg Lys Leu Ala Arg His Leu Lys Glu His Gln Gly Val Glu 
465                 470                 475                 480 

Ile Asn Pro Asn Ser Ile Phe Asp Ile Gln Ile Lys Arg Leu His Glu 
                485                 490                 495     

Tyr Lys Arg Gln Gln Met Asn Ala Leu Tyr Val Ile His Lys Tyr Leu 
            500                 505                 510         


Asp Ile Lys Ala Gly Asn Ile Pro Ala Arg Pro Ile Thr Ile Phe Phe 
        515                 520                 525             

Gly Gly Lys Ala Ala Pro Ala Tyr Thr Ile Ala Gln Asp Ile Ile His 
    530                 535                 540                 

Leu Ile Leu Cys Met Ser Glu Val Ile Ala Asn Asp Pro Ala Val Ala 
545                 550                 555                 560 

Pro His Leu Gln Val Val Met Val Glu Asn Tyr Asn Val Thr Ala Ala 
                565                 570                 575     

Ser Phe Leu Ile Pro Ala Cys Asp Ile Ser Glu Gln Ile Ser Leu Ala 
            580                 585                 590         

Ser Lys Glu Ala Ser Gly Thr Gly Asn Met Lys Phe Met Leu Asn Gly 
        595                 600                 605             

Ala Leu Thr Leu Gly Thr Met Asp Gly Ala Asn Val Glu Ile Ala Glu 
    610                 615                 620                 

Leu Val Gly Glu Glu Asn Ile Tyr Ile Phe Gly Glu Asp Ser Glu Thr 
625                 630                 635                 640 

Val Ile Asp Leu Tyr Ala Lys Ala Ala Tyr Lys Ser Ser Glu Phe Tyr 
                645                 650                 655     

Ala Arg Glu Ala Ile Lys Pro Leu Val Asp Phe Ile Val Ser Asp Ala 
            660                 665                 670         

Val Leu Ala Ala Gly Asn Lys Glu Arg Leu Glu Arg Phe Tyr Asn Glu 
        675                 680                 685             

Leu Ile Asn Lys Asp Trp Phe Met Thr Leu Leu Asp Leu Glu Asp Tyr 
    690                 695                 700                 

Ile Lys Val Lys Glu Gln Met Leu Ala Asp Tyr Glu Asp Arg Asp Ala 
705                 710                 715                 720 

Trp Leu Asp Lys Val Ile Val Asn Ile Ser Lys Ala Gly Phe Phe Ser 
                725                 730                 735     

Ser Asp Arg Thr Ile Ala Gln Tyr Asn Glu Asp Ile Trp His Leu Asn 
            740                 745                 750         


<210>   4401
<211>   1515
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4401
atgaaaaaac gtcaaagtgg tgtgttgatg cacatctctt ctcttccagg agcttacgga   60
atcggatcat ttggtcaaag tgcttacgac ttcgttgatt tcttggtccg tacaaaacaa   120
cgttactggc aaatccttcc attaggagca actagttacg gggattctcc ttaccaatct   180
ttctcagcct tcgcaggaaa cactcatttt atcgatttag atatcttggt ggagcaaggt   240
ttgttggaag caagtgacct tgaaggagtt gactttggta gcgatgcgtc tgaagttgac   300
tatgctaaaa tctactatgc acgtcgtcct cttttagaaa aagcggtgaa acgtttcttt   360
gaagtcggag atgttaaaga ttttgagaaa tttgctcaag acaaccaatc atggcttgag   420
ctctttgctg agtatatggc tatcaaagag tattttgaca atcttgcttg gactgaatgg   480
ccagatgcag atgctcgtgc tcgtaaagct tcagcacttg aaagctatcg tgagcaattg   540
gcagacaagt tggtttacca ccgtgtgact caatacttct tcttccaaca atggttgaaa   600
ttgaaagctt acgctaacga caaccacatc gaaatcgttg gggacatgcc aatctacgta   660
gcggaagatt caagtgatat gtgggcaaat ccacatctct tcaaaacaga tgtcaatggt   720
aaggctactt gtatcgcagg atgcccacca gatgagtttt ctgtaactgg tcagctttgg   780
ggtaatccaa tctatgactg ggaagcaatg gacaaagacg gctacaaatg gtggattgaa   840
cgcttgcgtg aaagcttcaa aatctacgat atcgttcgta tcgaccactt ccgtggcttc   900
gaatcttact gggaaatccc tgctggttcc gatacagcag cacctggtga gtgggtgaaa   960
ggtccaggtt acaagctttt tgcagccgtt aaggaagaac ttggtgagct aaacatcatc   1020
gcagaagacc ttggcttcat gacagatgaa gtgatcgaat tgcgtgaacg tactggcttc   1080
ccaggaatga agattcttca atttgccttc aacccagaag acgaaagcat tgatagccca   1140
cacttggcac ctgctaactc agttatgtac acaggaacac acgataacaa tacggttctt   1200
ggttggtacc gtaatgagat tgatgatgcg actcgtgagt acatggctcg ttacacgaac   1260
cgtaaagaat acgaaacagt ggtacacgct atgcttcgta cagtattttc atcagttagc   1320
tttatggcaa ttgcaactat gcaagattta ctagaattgg atgaggcagc tcgtatgaac   1380
ttcccatcta cccttggtgg aaactggtct tggcgtatga ctgaagatca attgacacca   1440
gctgtcgagg aaggtttgct tgacttgaca acaatttatc gccgaattaa tgaaaatttg   1500
gtagatttaa agaaa                                                    1515

<210>   4402
<211>   505
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   4-alpha-glucanotransferase (malQ)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903958 (0.E+01)

<400>   4402
Met Lys Lys Arg Gln Ser Gly Val Leu Met His Ile Ser Ser Leu Pro 
1               5                   10                  15      

Gly Ala Tyr Gly Ile Gly Ser Phe Gly Gln Ser Ala Tyr Asp Phe Val 
            20                  25                  30          

Asp Phe Leu Val Arg Thr Lys Gln Arg Tyr Trp Gln Ile Leu Pro Leu 
        35                  40                  45              

Gly Ala Thr Ser Tyr Gly Asp Ser Pro Tyr Gln Ser Phe Ser Ala Phe 
    50                  55                  60                  

Ala Gly Asn Thr His Phe Ile Asp Leu Asp Ile Leu Val Glu Gln Gly 
65                  70                  75                  80  

Leu Leu Glu Ala Ser Asp Leu Glu Gly Val Asp Phe Gly Ser Asp Ala 
                85                  90                  95      

Ser Glu Val Asp Tyr Ala Lys Ile Tyr Tyr Ala Arg Arg Pro Leu Leu 
            100                 105                 110         

Glu Lys Ala Val Lys Arg Phe Phe Glu Val Gly Asp Val Lys Asp Phe 
        115                 120                 125             

Glu Lys Phe Ala Gln Asp Asn Gln Ser Trp Leu Glu Leu Phe Ala Glu 
    130                 135                 140                 

Tyr Met Ala Ile Lys Glu Tyr Phe Asp Asn Leu Ala Trp Thr Glu Trp 
145                 150                 155                 160 

Pro Asp Ala Asp Ala Arg Ala Arg Lys Ala Ser Ala Leu Glu Ser Tyr 
                165                 170                 175     

Arg Glu Gln Leu Ala Asp Lys Leu Val Tyr His Arg Val Thr Gln Tyr 
            180                 185                 190         

Phe Phe Phe Gln Gln Trp Leu Lys Leu Lys Ala Tyr Ala Asn Asp Asn 
        195                 200                 205             

His Ile Glu Ile Val Gly Asp Met Pro Ile Tyr Val Ala Glu Asp Ser 
    210                 215                 220                 

Ser Asp Met Trp Ala Asn Pro His Leu Phe Lys Thr Asp Val Asn Gly 
225                 230                 235                 240 

Lys Ala Thr Cys Ile Ala Gly Cys Pro Pro Asp Glu Phe Ser Val Thr 
                245                 250                 255     

Gly Gln Leu Trp Gly Asn Pro Ile Tyr Asp Trp Glu Ala Met Asp Lys 
            260                 265                 270         

Asp Gly Tyr Lys Trp Trp Ile Glu Arg Leu Arg Glu Ser Phe Lys Ile 
        275                 280                 285             

Tyr Asp Ile Val Arg Ile Asp His Phe Arg Gly Phe Glu Ser Tyr Trp 
    290                 295                 300                 

Glu Ile Pro Ala Gly Ser Asp Thr Ala Ala Pro Gly Glu Trp Val Lys 
305                 310                 315                 320 

Gly Pro Gly Tyr Lys Leu Phe Ala Ala Val Lys Glu Glu Leu Gly Glu 
                325                 330                 335     

Leu Asn Ile Ile Ala Glu Asp Leu Gly Phe Met Thr Asp Glu Val Ile 
            340                 345                 350         

Glu Leu Arg Glu Arg Thr Gly Phe Pro Gly Met Lys Ile Leu Gln Phe 
        355                 360                 365             

Ala Phe Asn Pro Glu Asp Glu Ser Ile Asp Ser Pro His Leu Ala Pro 
    370                 375                 380                 

Ala Asn Ser Val Met Tyr Thr Gly Thr His Asp Asn Asn Thr Val Leu 
385                 390                 395                 400 

Gly Trp Tyr Arg Asn Glu Ile Asp Asp Ala Thr Arg Glu Tyr Met Ala 
                405                 410                 415     

Arg Tyr Thr Asn Arg Lys Glu Tyr Glu Thr Val Val His Ala Met Leu 
            420                 425                 430         

Arg Thr Val Phe Ser Ser Val Ser Phe Met Ala Ile Ala Thr Met Gln 
        435                 440                 445             

Asp Leu Leu Glu Leu Asp Glu Ala Ala Arg Met Asn Phe Pro Ser Thr 
    450                 455                 460                 

Leu Gly Gly Asn Trp Ser Trp Arg Met Thr Glu Asp Gln Leu Thr Pro 
465                 470                 475                 480 

Ala Val Glu Glu Gly Leu Leu Asp Leu Thr Thr Ile Tyr Arg Arg Ile 
                485                 490                 495     

Asn Glu Asn Leu Val Asp Leu Lys Lys 
            500                 505 

<210>   4403
<211>   1269
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4403
atgtcatcta aatttatgaa gagcgctgcg gtgcttggaa ctgctacact tgctagcttg   60
cttttggtag cttgcggaag caaaactgct gataagcctg ctgattctgg ttcatctgaa   120
gtcaaagaac tcactgtata tgtagacgag ggatataaga gctatattga agaggttgct   180
aaagcttatg aaaaagaagc tggagtaaaa gtcactctta aaactggtga tgctctagga   240
ggtcttgata aactttctct tgacaaccaa tctggtaatg tccctgatgt tatgatggct   300
ccatacgacc gtgtaggtag ccttggttct gacggacaac tttcagaagt gaaattgagc   360
gatggtgcta aaacagacga cacaactaaa tctcttgtaa cagctgctaa tggtaaagtt   420
tacggtgctc ctgccgttat cgagtcactt gttatgtact acaacaaaga cttggtgaaa   480
gatgctccaa aaacatttgc tgacttggaa aaccttgcta aagatagcaa atacgcattc   540
gctggtgaag atggtaaaac tactgccttc ctagctgact ggacaaactt ctactataca   600
tatggacttc ttgccggtaa cggtgcttac gtctttggcc aaaacggtaa agacgctaaa   660
gacatcggtc ttgcaaacga cggttctatc gtaggtatca actacgctaa atcttggtac   720
gaaaaatggc ctaaaggtat gcaagataca gaaggtgctg gaaacttaat ccaaactcaa   780
ttccaagaag gtaaaacagc tgctatcatc gacggacctt ggaaagctca agcctttaaa   840
gatgctaaag taaactacgg agttgcaact atcccaactc ttccaaatgg aaaagaatat   900
gctgcattcg gtggtggtaa agcttgggtc attcctcaag ccgttaagaa ccttgaagct   960
tctcaaaaat ttgtagactt ccttgttgca actgaacaac aaaaagtatt atatgataag   1020
actaacgaaa tcccagctaa tactgaggct cgttcatacg ctgaaggtaa aaacgatgag   1080
ttgacaacag ctgttatcaa acagttcaag aacactcaac cactgccaaa catctctcaa   1140
atgtctgcag tttgggatcc agcgaaaaat atgctctttg atgctgtaag tggtcaaaaa   1200
gatgctaaaa cagctgctaa cgatgctgta acattgatca aagaaacaat caaacaaaaa   1260
tttggtgaa                                                           1269

<210>   4404
<211>   423
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   maltose/maltodextrin ABC transporter, maltose/maltodextrin-binding prot
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15903959 (0.E+01)

<400>   4404
Met Ser Ser Lys Phe Met Lys Ser Ala Ala Val Leu Gly Thr Ala Thr 
1               5                   10                  15      

Leu Ala Ser Leu Leu Leu Val Ala Cys Gly Ser Lys Thr Ala Asp Lys 
            20                  25                  30          

Pro Ala Asp Ser Gly Ser Ser Glu Val Lys Glu Leu Thr Val Tyr Val 
        35                  40                  45              

Asp Glu Gly Tyr Lys Ser Tyr Ile Glu Glu Val Ala Lys Ala Tyr Glu 
    50                  55                  60                  

Lys Glu Ala Gly Val Lys Val Thr Leu Lys Thr Gly Asp Ala Leu Gly 
65                  70                  75                  80  

Gly Leu Asp Lys Leu Ser Leu Asp Asn Gln Ser Gly Asn Val Pro Asp 

                85                  90                  95      

Val Met Met Ala Pro Tyr Asp Arg Val Gly Ser Leu Gly Ser Asp Gly 
            100                 105                 110         

Gln Leu Ser Glu Val Lys Leu Ser Asp Gly Ala Lys Thr Asp Asp Thr 
        115                 120                 125             

Thr Lys Ser Leu Val Thr Ala Ala Asn Gly Lys Val Tyr Gly Ala Pro 
    130                 135                 140                 

Ala Val Ile Glu Ser Leu Val Met Tyr Tyr Asn Lys Asp Leu Val Lys 
145                 150                 155                 160 

Asp Ala Pro Lys Thr Phe Ala Asp Leu Glu Asn Leu Ala Lys Asp Ser 
                165                 170                 175     

Lys Tyr Ala Phe Ala Gly Glu Asp Gly Lys Thr Thr Ala Phe Leu Ala 
            180                 185                 190         

Asp Trp Thr Asn Phe Tyr Tyr Thr Tyr Gly Leu Leu Ala Gly Asn Gly 
        195                 200                 205             

Ala Tyr Val Phe Gly Gln Asn Gly Lys Asp Ala Lys Asp Ile Gly Leu 
    210                 215                 220                 

Ala Asn Asp Gly Ser Ile Val Gly Ile Asn Tyr Ala Lys Ser Trp Tyr 
225                 230                 235                 240 

Glu Lys Trp Pro Lys Gly Met Gln Asp Thr Glu Gly Ala Gly Asn Leu 
                245                 250                 255     

Ile Gln Thr Gln Phe Gln Glu Gly Lys Thr Ala Ala Ile Ile Asp Gly 
            260                 265                 270         

Pro Trp Lys Ala Gln Ala Phe Lys Asp Ala Lys Val Asn Tyr Gly Val 
        275                 280                 285             

Ala Thr Ile Pro Thr Leu Pro Asn Gly Lys Glu Tyr Ala Ala Phe Gly 
    290                 295                 300                 

Gly Gly Lys Ala Trp Val Ile Pro Gln Ala Val Lys Asn Leu Glu Ala 
305                 310                 315                 320 

Ser Gln Lys Phe Val Asp Phe Leu Val Ala Thr Glu Gln Gln Lys Val 
                325                 330                 335     

Leu Tyr Asp Lys Thr Asn Glu Ile Pro Ala Asn Thr Glu Ala Arg Ser 
            340                 345                 350         

Tyr Ala Glu Gly Lys Asn Asp Glu Leu Thr Thr Ala Val Ile Lys Gln 
        355                 360                 365             

Phe Lys Asn Thr Gln Pro Leu Pro Asn Ile Ser Gln Met Ser Ala Val 
    370                 375                 380                 

Trp Asp Pro Ala Lys Asn Met Leu Phe Asp Ala Val Ser Gly Gln Lys 
385                 390                 395                 400 

Asp Ala Lys Thr Ala Ala Asn Asp Ala Val Thr Leu Ile Lys Glu Thr 
                405                 410                 415     

Ile Lys Gln Lys Phe Gly Glu 
            420             

<210>   4405
<211>   1305
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4405
atgaaaggag ttaatatgga aaagcaacaa cctagtaaag cagccctgct gtctatcatt   60
cctgggttag gacagattta caataaacaa aaagccaaag gttttatctt ccttggtgta   120
accatcgtat ttgtccttta cttcctagca cttgcaaccc ctgaattgag caacctcatc   180
actcttggtg acaaaccagg tcgtgataat tccctcttta tgctgattcg tggtgccttc   240
catctaatct ttgtaatcgt ttatgtactc ttttatttct caaatatcaa agatgcacat   300
acgattgcaa aacgcattaa caatggaatt ccagttccac gcacactcaa agacatgatc   360
aaagggattt atgaaaatgg cttcccttac ctcttgatca ttccatctta tgttgccatg   420
accttcgcga ttatcttccc agttatcgta accttgatga tcgcctttac caactacgac   480
ttccaacact tgccaccaaa caagttgttg gactgggttg gtttgaccaa ctttacaaac   540
atttggagct tgagtacctt ccgttctgcc tttggttctg ttctttcttg gactatcatt   600
tgggctttgg cagcttctac tttacaaatc gtaattggta tcttcacagc tatcattgcc   660
aaccaaccat ttatcaaagg aaaacgtatc tttggtgtta ttttccttct tccttgggct   720
gtcccagcct tcatcactat cttgacattc tcaaacatgt ttaacgatag tgtcggtgct   780
atcaacactc aagtattgcc aatcttggct aaattccttc ctttccttga tggagctctt   840
attccttgga aaacagaccc aacttggact aagattgcct tgattatgat gcaaggttgg   900
ctcggattcc catacatcta cgttctgacc ttgggtatct tgcaatctat tcctaacgac   960
ctttacgaag cagcttatat tgacggtgcc aacgcttggc aaaaattccg caacatcact   1020
ttcccaatga ttttggctgt tgcggcacct actttgatta gccaatacac cttcaacttt   1080
aacaacttct ctatcatgta cctcttcaat ggtggaggac ctggtagtgt cggaggtgga   1140
gctggttcaa ccgatatctt gatctcatgg atctaccgtt tgacaacagg tacatctcct   1200
caatactcaa tggcggcagc tgttaccttg attatctcta tcattgtcat ctcaatctct   1260
atgatcgcat tcaagaaact acacgcattt gatatggagg acgtc                   1305

<210>   4406
<211>   435
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   maltodextrin ABC transporter, permease protein (malC)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903960 (0.E+01)

<400>   4406
Met Lys Gly Val Asn Met Glu Lys Gln Gln Pro Ser Lys Ala Ala Leu 
1               5                   10                  15      

Leu Ser Ile Ile Pro Gly Leu Gly Gln Ile Tyr Asn Lys Gln Lys Ala 
            20                  25                  30          

Lys Gly Phe Ile Phe Leu Gly Val Thr Ile Val Phe Val Leu Tyr Phe 
        35                  40                  45              

Leu Ala Leu Ala Thr Pro Glu Leu Ser Asn Leu Ile Thr Leu Gly Asp 
    50                  55                  60                  

Lys Pro Gly Arg Asp Asn Ser Leu Phe Met Leu Ile Arg Gly Ala Phe 
65                  70                  75                  80  

His Leu Ile Phe Val Ile Val Tyr Val Leu Phe Tyr Phe Ser Asn Ile 
                85                  90                  95      

Lys Asp Ala His Thr Ile Ala Lys Arg Ile Asn Asn Gly Ile Pro Val 
            100                 105                 110         

Pro Arg Thr Leu Lys Asp Met Ile Lys Gly Ile Tyr Glu Asn Gly Phe 
        115                 120                 125             

Pro Tyr Leu Leu Ile Ile Pro Ser Tyr Val Ala Met Thr Phe Ala Ile 
    130                 135                 140                 

Ile Phe Pro Val Ile Val Thr Leu Met Ile Ala Phe Thr Asn Tyr Asp 
145                 150                 155                 160 

Phe Gln His Leu Pro Pro Asn Lys Leu Leu Asp Trp Val Gly Leu Thr 
                165                 170                 175     

Asn Phe Thr Asn Ile Trp Ser Leu Ser Thr Phe Arg Ser Ala Phe Gly 
            180                 185                 190         

Ser Val Leu Ser Trp Thr Ile Ile Trp Ala Leu Ala Ala Ser Thr Leu 
        195                 200                 205             

Gln Ile Val Ile Gly Ile Phe Thr Ala Ile Ile Ala Asn Gln Pro Phe 
    210                 215                 220                 

Ile Lys Gly Lys Arg Ile Phe Gly Val Ile Phe Leu Leu Pro Trp Ala 
225                 230                 235                 240 

Val Pro Ala Phe Ile Thr Ile Leu Thr Phe Ser Asn Met Phe Asn Asp 
                245                 250                 255     

Ser Val Gly Ala Ile Asn Thr Gln Val Leu Pro Ile Leu Ala Lys Phe 
            260                 265                 270         

Leu Pro Phe Leu Asp Gly Ala Leu Ile Pro Trp Lys Thr Asp Pro Thr 
        275                 280                 285             

Trp Thr Lys Ile Ala Leu Ile Met Met Gln Gly Trp Leu Gly Phe Pro 
    290                 295                 300                 

Tyr Ile Tyr Val Leu Thr Leu Gly Ile Leu Gln Ser Ile Pro Asn Asp 
305                 310                 315                 320 

Leu Tyr Glu Ala Ala Tyr Ile Asp Gly Ala Asn Ala Trp Gln Lys Phe 
                325                 330                 335     

Arg Asn Ile Thr Phe Pro Met Ile Leu Ala Val Ala Ala Pro Thr Leu 
            340                 345                 350         

Ile Ser Gln Tyr Thr Phe Asn Phe Asn Asn Phe Ser Ile Met Tyr Leu 
        355                 360                 365             

Phe Asn Gly Gly Gly Pro Gly Ser Val Gly Gly Gly Ala Gly Ser Thr 
    370                 375                 380                 

Asp Ile Leu Ile Ser Trp Ile Tyr Arg Leu Thr Thr Gly Thr Ser Pro 
385                 390                 395                 400 

Gln Tyr Ser Met Ala Ala Ala Val Thr Leu Ile Ile Ser Ile Ile Val 
                405                 410                 415     

Ile Ser Ile Ser Met Ile Ala Phe Lys Lys Leu His Ala Phe Asp Met 
            420                 425                 430         

Glu Asp Val 
        435 

<210>   4407
<211>   861
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4407
ttgatatgga ggacgtctaa gatgaataac tcaattaaac tcaaacgtag actgactcaa   60
agccttactt acctttacct gattggtcta tcaattgtaa ttatctatcc actgttgatt   120
accattatgt cagcctttaa agcaggtaac gtctcagcct ttaaactaga tactaatatc   180
gacctcaatt ttgataactt taaaggcctc ttcactgaaa ccttgtacgg tacttggtac   240
ctcaacactt tgattatcgc cttaattacc atggctgttc aaacaagtat catcgtactt   300
gctggttatg cttacagccg ttacaacttc ttggctcgta aacaaagttt ggtcttcttc   360
ttgatcatcc aaatggtgcc aactatggcc gctttgacag ccttcttcgt tatggcgctt   420
atgttgaacg cccttaacca caactggttc ctcatcttcc tctacgttgg tggtggtatc   480
ccgatgaatg cttggctcat gaaaggctac ttcgatacag tgccaatgtc tttagacgaa   540
tctgcaaaac tagacggtgc aggacacttc cgccgcttct ggcaaattgt tctaccactt   600
gttcgcccaa tggttgccgt acaagctctc tgggccttca tgggaccttt cggggactac   660

atcctctcta gtttcttgct tcgtgagaaa gaatacttta ctgttgccgt aggtctccaa   720
accttcgtta acaatgcgaa aaacttgaag attgcctact tctcagcagg tgctatcctc   780
atcgcccttc caatctgtat tctcttcttc ttcctacaaa agaactttgt ttcaggactt   840
acaagtggtg gcgacaaggg a                                             861

<210>   4408
<211>   287
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   maltodextrin ABC transporter, permease protein (malD)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903961 (e-159)

<400>   4408
Met Ile Trp Arg Thr Ser Lys Met Asn Asn Ser Ile Lys Leu Lys Arg 
1               5                   10                  15      

Arg Leu Thr Gln Ser Leu Thr Tyr Leu Tyr Leu Ile Gly Leu Ser Ile 
            20                  25                  30          

Val Ile Ile Tyr Pro Leu Leu Ile Thr Ile Met Ser Ala Phe Lys Ala 
        35                  40                  45              

Gly Asn Val Ser Ala Phe Lys Leu Asp Thr Asn Ile Asp Leu Asn Phe 
    50                  55                  60                  

Asp Asn Phe Lys Gly Leu Phe Thr Glu Thr Leu Tyr Gly Thr Trp Tyr 
65                  70                  75                  80  

Leu Asn Thr Leu Ile Ile Ala Leu Ile Thr Met Ala Val Gln Thr Ser 
                85                  90                  95      

Ile Ile Val Leu Ala Gly Tyr Ala Tyr Ser Arg Tyr Asn Phe Leu Ala 
            100                 105                 110         

Arg Lys Gln Ser Leu Val Phe Phe Leu Ile Ile Gln Met Val Pro Thr 
        115                 120                 125             

Met Ala Ala Leu Thr Ala Phe Phe Val Met Ala Leu Met Leu Asn Ala 
    130                 135                 140                 

Leu Asn His Asn Trp Phe Leu Ile Phe Leu Tyr Val Gly Gly Gly Ile 
145                 150                 155                 160 

Pro Met Asn Ala Trp Leu Met Lys Gly Tyr Phe Asp Thr Val Pro Met 
                165                 170                 175     

Ser Leu Asp Glu Ser Ala Lys Leu Asp Gly Ala Gly His Phe Arg Arg 
            180                 185                 190         

Phe Trp Gln Ile Val Leu Pro Leu Val Arg Pro Met Val Ala Val Gln 
        195                 200                 205             

Ala Leu Trp Ala Phe Met Gly Pro Phe Gly Asp Tyr Ile Leu Ser Ser 
    210                 215                 220                 

Phe Leu Leu Arg Glu Lys Glu Tyr Phe Thr Val Ala Val Gly Leu Gln 
225                 230                 235                 240 

Thr Phe Val Asn Asn Ala Lys Asn Leu Lys Ile Ala Tyr Phe Ser Ala 
                245                 250                 255     

Gly Ala Ile Leu Ile Ala Leu Pro Ile Cys Ile Leu Phe Phe Phe Leu 
            260                 265                 270         

Gln Lys Asn Phe Val Ser Gly Leu Thr Ser Gly Gly Asp Lys Gly 
        275                 280                 285         

<210>   4409
<211>   798
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4409
atgcttccat atccattttc ctatttttca agtatttggg gggttcgtaa gcccctgtcc   60
aaacgtttcg agctcaactg gtttcaactt ctctttacca gtatcttcct tatcagcttg   120
tctatggtac ccattgctat ccaaaacagc tcccaggaga cctatccgct agaaactttt   180
atcgataatg tctatgaacc tctgacagat aaggttgtcc aggatctctc tgaacatgct   240
acaattgtcg atggcacatt aacttatact ggaacagcta gtcaagcccc ttctgttgtg   300
attggtccaa gtcaaatcaa ggaattacct aaggacttgc aactgcattt cgatacaaat   360
gagctagtca tcagcaagga aagcaaggaa ctgacccgca tctcttaccg agccattcag   420
actgagagtt tcaaaagcaa agacagcttg acccaagcaa tttctaaaga ctggtaccaa   480
caaaatcgtg tctatatcag cctcttccta gttctcggtg cgagcttcct ctttggtttg   540
aatttcttta tcgtctctct tggagctagc tttctccttt atatcaccaa aagatcacgc   600
ctcttttcat ttaatacctt taaagagtgc taccatttta tcttgaactg tttaggattg   660
ccgactctga ttacacttat tttgggatta tttggccaaa atatgacaac cctgattact   720
gtacaaaata ttctttttgt tctgtatctg gtcactatct tttataaaac acatttccgt   780
gatccaaatt accataaa                                                 798

<210>   4410
<211>   266
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   malA protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903962 (e-149)

<400>   4410
Met Leu Pro Tyr Pro Phe Ser Tyr Phe Ser Ser Ile Trp Gly Val Arg 
1               5                   10                  15      

Lys Pro Leu Ser Lys Arg Phe Glu Leu Asn Trp Phe Gln Leu Leu Phe 
            20                  25                  30          

Thr Ser Ile Phe Leu Ile Ser Leu Ser Met Val Pro Ile Ala Ile Gln 
        35                  40                  45              

Asn Ser Ser Gln Glu Thr Tyr Pro Leu Glu Thr Phe Ile Asp Asn Val 
    50                  55                  60                  

Tyr Glu Pro Leu Thr Asp Lys Val Val Gln Asp Leu Ser Glu His Ala 
65                  70                  75                  80  

Thr Ile Val Asp Gly Thr Leu Thr Tyr Thr Gly Thr Ala Ser Gln Ala 
                85                  90                  95      

Pro Ser Val Val Ile Gly Pro Ser Gln Ile Lys Glu Leu Pro Lys Asp 
            100                 105                 110         

Leu Gln Leu His Phe Asp Thr Asn Glu Leu Val Ile Ser Lys Glu Ser 
        115                 120                 125             

Lys Glu Leu Thr Arg Ile Ser Tyr Arg Ala Ile Gln Thr Glu Ser Phe 
    130                 135                 140                 

Lys Ser Lys Asp Ser Leu Thr Gln Ala Ile Ser Lys Asp Trp Tyr Gln 
145                 150                 155                 160 

Gln Asn Arg Val Tyr Ile Ser Leu Phe Leu Val Leu Gly Ala Ser Phe 
                165                 170                 175     

Leu Phe Gly Leu Asn Phe Phe Ile Val Ser Leu Gly Ala Ser Phe Leu 
            180                 185                 190         

Leu Tyr Ile Thr Lys Arg Ser Arg Leu Phe Ser Phe Asn Thr Phe Lys 
        195                 200                 205             

Glu Cys Tyr His Phe Ile Leu Asn Cys Leu Gly Leu Pro Thr Leu Ile 
    210                 215                 220                 

Thr Leu Ile Leu Gly Leu Phe Gly Gln Asn Met Thr Thr Leu Ile Thr 
225                 230                 235                 240 

Val Gln Asn Ile Leu Phe Val Leu Tyr Leu Val Thr Ile Phe Tyr Lys 
                245                 250                 255     

Thr His Phe Arg Asp Pro Asn Tyr His Lys 
            260                 265     

<210>   4411
<211>   984
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   4411
atgcccgtta cgattaaaga cgtggccaag gctgctggtg tttcgccttc aaccgtaacc   60
cgtgttattc aaaataaatc aaccattagc gacgaaacaa aaaaacgtgt tcgcaaagct   120
atgaaggaac tcaactacca cccaaacctc aacgctcgta gcttggtaag cagctatact   180
caggttatcg gattagttct tcctgatgac tcagacgcct tctaccagaa tcctttcttt   240
ccatcggttc tacgtggcat ctctcaagtc gcatctgaaa accactatgc cattcagata   300
gcaacaggga aagatgagaa ggagcgtctc aacgctattt cacaaatggt ctacggcaag   360
cgtgtagatg ggctaatttt tctctatgcc caagaagaag accctctcgt aaaactcgtc   420
gcagaagaac agttcccctt ccttatctta ggtaaatctc tatctccttt catcccactt   480
gtcgacaacg acaatgttca agctggtttt gatgcgactg aatatttcat caaaaaaggc   540
tgcaaacgca ttgcctttat cggaggaagt aaaaagctct tcgtgaccaa agaccgttta   600
acaggctatg aacaggcgct taaacattac aaacttacca ctgacaacaa tcgcatctac   660
tttgccgacg agtttctgga agaaaagggc tataaattta gcaagcgatt attcaagcac   720
gatccacaaa ttgatgctat catcacaacc gatagcctcc tagctgaagg tgtttgtaac   780
tatattgcca aacaccagct ggatgtccct gttctcagct ttgactcggt taatcccaag   840
ctcaacttgg cagcctatgt cgatatcaat agtttagagc ttggtcgtgt ttcccttgaa   900
actattctcc agattattaa tgataataaa aacaataaac aaatttgtta ccgtcaattg   960
atcgcccaca aaattatcga aaaa                                          984

<210>   4412
<211>   328
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   maltose operon transcriptional repressor (malR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903963 (0.E+01)

<400>   4412
Met Pro Val Thr Ile Lys Asp Val Ala Lys Ala Ala Gly Val Ser Pro 
1               5                   10                  15      

Ser Thr Val Thr Arg Val Ile Gln Asn Lys Ser Thr Ile Ser Asp Glu 
            20                  25                  30          

Thr Lys Lys Arg Val Arg Lys Ala Met Lys Glu Leu Asn Tyr His Pro 
        35                  40                  45              

Asn Leu Asn Ala Arg Ser Leu Val Ser Ser Tyr Thr Gln Val Ile Gly 
    50                  55                  60                  

Leu Val Leu Pro Asp Asp Ser Asp Ala Phe Tyr Gln Asn Pro Phe Phe 
65                  70                  75                  80  

Pro Ser Val Leu Arg Gly Ile Ser Gln Val Ala Ser Glu Asn His Tyr 
                85                  90                  95      

Ala Ile Gln Ile Ala Thr Gly Lys Asp Glu Lys Glu Arg Leu Asn Ala 
            100                 105                 110         

Ile Ser Gln Met Val Tyr Gly Lys Arg Val Asp Gly Leu Ile Phe Leu 
        115                 120                 125             

Tyr Ala Gln Glu Glu Asp Pro Leu Val Lys Leu Val Ala Glu Glu Gln 
    130                 135                 140                 

Phe Pro Phe Leu Ile Leu Gly Lys Ser Leu Ser Pro Phe Ile Pro Leu 
145                 150                 155                 160 

Val Asp Asn Asp Asn Val Gln Ala Gly Phe Asp Ala Thr Glu Tyr Phe 
                165                 170                 175     

Ile Lys Lys Gly Cys Lys Arg Ile Ala Phe Ile Gly Gly Ser Lys Lys 
            180                 185                 190         

Leu Phe Val Thr Lys Asp Arg Leu Thr Gly Tyr Glu Gln Ala Leu Lys 
        195                 200                 205             

His Tyr Lys Leu Thr Thr Asp Asn Asn Arg Ile Tyr Phe Ala Asp Glu 
    210                 215                 220                 

Phe Leu Glu Glu Lys Gly Tyr Lys Phe Ser Lys Arg Leu Phe Lys His 
225                 230                 235                 240 

Asp Pro Gln Ile Asp Ala Ile Ile Thr Thr Asp Ser Leu Leu Ala Glu 
                245                 250                 255     

Gly Val Cys Asn Tyr Ile Ala Lys His Gln Leu Asp Val Pro Val Leu 
            260                 265                 270         

Ser Phe Asp Ser Val Asn Pro Lys Leu Asn Leu Ala Ala Tyr Val Asp 
        275                 280                 285             

Ile Asn Ser Leu Glu Leu Gly Arg Val Ser Leu Glu Thr Ile Leu Gln 
    290                 295                 300                 

Ile Ile Asn Asp Asn Lys Asn Asn Lys Gln Ile Cys Tyr Arg Gln Leu 
305                 310                 315                 320 

Ile Ala His Lys Ile Ile Glu Lys 
                325             

<210>   4413
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4413
ttgaaaaaac ttgatactat gcgttttatt gtgggaagat ttacttcctt ttctactgaa   60
attgagtctt ttcccaagat ctttttatac tcaatgaaaa tcaaagtgca aactaggaag   120
ctagccgcag gttgctcaaa acactgtttt gaggttgtag atgaaactga cgaagtcagt   180
aaccatacct acggcaaggt gaagctgacg tggtttgaag agattttcga agagtat      237

<210>   4414
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4414
Met Lys Lys Leu Asp Thr Met Arg Phe Ile Val Gly Arg Phe Thr Ser 
1               5                   10                  15      

Phe Ser Thr Glu Ile Glu Ser Phe Pro Lys Ile Phe Leu Tyr Ser Met 

            20                  25                  30          

Lys Ile Lys Val Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys His 
        35                  40                  45              

Cys Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Asn His Thr Tyr 
    50                  55                  60                  

Gly Lys Val Lys Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr 
65                  70                  75                  

<210>   4415
<211>   939
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4415
atgaaacaaa caaaacgaat taagcggtgg cgctattatc tgcgccgctt tgcttatcag   60
ataaaaattt tacgtgtctt acaaagtatc tctcgagaaa agtatgatga gaagatttcg   120
gcctctctgg tctatggttt tttatcagca gtagcagtta atttcttttt ccaaccaggg   180
catgtgtatt cgagtggtgc aacaggtctg gcacagatta tctctgcctt gagtaatcac   240
tggtttggtt ttcatattcc gatttcgcta agcttctacg ccattaactt ccctttgatg   300
gtcttagctt ggtatcagat tggccataag ttcaccgtct ttacctttat cacggtatct   360
atgagttcct tctttatcca gtttgtccct gtggcaacct tgacagagga tcccattatc   420
aattcccttt ttgggggtgt tgttatgggt ttggggattg gttttgctct tcgaaacaat   480
atctccagtg gtgggacgga tatcgtcagc ctgactattc gtaagaaaac gggtaagaat   540
gtcggtagta tttctttctt ggtaaatgga actatcatgc tgatagcagg tttgaccttt   600
ggttggaaat acgctcttta ttctatgatt accatctttg tctctagccg tgtgacagac   660
gcagtcttta ctaagcaaaa gcgtatgcag gccatgattg tgacaaatca tccagagaag   720
gtaattgaaa aaatccataa aaaattgcac cgcggagcaa ccatgatcca cgatgcagaa   780
ggaacctata atcacgagag aaaggcagtt ttaatcactg tcattacacg tgcagagttt   840
aatgaattta aacagattat gacacaagtg gatccaagct cctttgtctc tgtctcggaa   900
aatgttcata ttctaggaag atttgttgag atagataat                          939

<210>   4416
<211>   313
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903964 (e-178)

<400>   4416
Met Lys Gln Thr Lys Arg Ile Lys Arg Trp Arg Tyr Tyr Leu Arg Arg 
1               5                   10                  15      

Phe Ala Tyr Gln Ile Lys Ile Leu Arg Val Leu Gln Ser Ile Ser Arg 
            20                  25                  30          

Glu Lys Tyr Asp Glu Lys Ile Ser Ala Ser Leu Val Tyr Gly Phe Leu 
        35                  40                  45              

Ser Ala Val Ala Val Asn Phe Phe Phe Gln Pro Gly His Val Tyr Ser 
    50                  55                  60                  

Ser Gly Ala Thr Gly Leu Ala Gln Ile Ile Ser Ala Leu Ser Asn His 
65                  70                  75                  80  

Trp Phe Gly Phe His Ile Pro Ile Ser Leu Ser Phe Tyr Ala Ile Asn 
                85                  90                  95      

Phe Pro Leu Met Val Leu Ala Trp Tyr Gln Ile Gly His Lys Phe Thr 
            100                 105                 110         

Val Phe Thr Phe Ile Thr Val Ser Met Ser Ser Phe Phe Ile Gln Phe 
        115                 120                 125             

Val Pro Val Ala Thr Leu Thr Glu Asp Pro Ile Ile Asn Ser Leu Phe 
    130                 135                 140                 

Gly Gly Val Val Met Gly Leu Gly Ile Gly Phe Ala Leu Arg Asn Asn 
145                 150                 155                 160 

Ile Ser Ser Gly Gly Thr Asp Ile Val Ser Leu Thr Ile Arg Lys Lys 
                165                 170                 175     

Thr Gly Lys Asn Val Gly Ser Ile Ser Phe Leu Val Asn Gly Thr Ile 
            180                 185                 190         

Met Leu Ile Ala Gly Leu Thr Phe Gly Trp Lys Tyr Ala Leu Tyr Ser 
        195                 200                 205             

Met Ile Thr Ile Phe Val Ser Ser Arg Val Thr Asp Ala Val Phe Thr 
    210                 215                 220                 

Lys Gln Lys Arg Met Gln Ala Met Ile Val Thr Asn His Pro Glu Lys 
225                 230                 235                 240 

Val Ile Glu Lys Ile His Lys Lys Leu His Arg Gly Ala Thr Met Ile 
                245                 250                 255     

His Asp Ala Glu Gly Thr Tyr Asn His Glu Arg Lys Ala Val Leu Ile 
            260                 265                 270         

Thr Val Ile Thr Arg Ala Glu Phe Asn Glu Phe Lys Gln Ile Met Thr 
        275                 280                 285             

Gln Val Asp Pro Ser Ser Phe Val Ser Val Ser Glu Asn Val His Ile 
    290                 295                 300                 

Leu Gly Arg Phe Val Glu Ile Asp Asn 
305                 310             

<210>   4417
<211>   1761
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4417
atgaaacgta gtatgtatgc tggtcgtgtt cgtgaggaac acatcggaca agaaataacc   60
ttgaaaggat gggttggccg tcgtcgtgac cttggtggtt tgatctttat cgatcttcgt   120
gaccgtgaag gaatcatgca gttggttatc aaccctgaaa aagtatctgc agaggttatg   180
gcaacagctg aaagccttcg tagcgaattt gttattgagg tgactggtca ggtcgctgcg   240
cgtgagcaag ccaatgataa gttgccaact ggtgcggttg agttaaacgt gacagctctt   300
attgtgctta acacagctaa gacaacacca tttgagatta aggatggcat tgaggcaaat   360
gacgatacac gtttgcgtta ccgttacctt gaccttcgtc gtccagaaat gttggaaaat   420
cttaaacttc gtgccaaggt gacccactct atccgcaact acttggatga gttggagttt   480
atcgacgtgg agacaccatt cctttctaag tcaacgcctg aaggggcgcg tgattattta   540
gtgccgtctc gtgttaataa ggggcatttt tacgctcttc ctcaaagtcc acaaatcacg   600
aaacagctct tgatgaatgc tggttttgac cgttactacc aaatcgttaa atgtttccgt   660
gacgaggact tgcgtggaga ccgccagcct gaatttactc aggtcgactt ggaaacgtcc   720
ttccttactg agcaagaaat ccaagatatt acagaaagct tgatcgcgcg cgtgatgaag   780
gaaacaaaag gcatcgaagt aacgctacca ttccctcgta tgaaatacga tgatgctatg   840
gctctttacg gttctgacaa gccagatact cgttttgaca tgttgcttca ggacttgaca   900
gaagtggtcc gaggtgtaga ctttaaagtc ttttcagaag cacctgctgt aaaagcgatt   960
gtggtcacag gagctgcgga caactattca cgtaaagaca tcgacaagat gacggaagta   1020
gccaaacagt atggtgccaa aggtcttgct tgggtcaagg tggttgatgg agaattaaac   1080
ggaccagttg ccaagttctt gactggtatc caagaagaat tgacaacagc gcttgttctt   1140
gaagataagg acttggttct ctttgtggcg gatacgcttg aagtggctaa tgcaacactg   1200
ggtgcccttc gtggacgtat tgctaaagag cttggcttga ttgataatga taagttcaac   1260
ttcctttggg tggttgactg gccgatgttt gaatggtctg aagaagaagg ccgctacatg   1320
agcgcccacc atcctttcac acttccacag gaagagactg ctcatgaatt agaaggtgat   1380
ttggctaagg ttcgtgccat tgcttacgat atcgtcttga acggttatga gcttggtggt   1440
ggtagccttc gtatcaacca aaaagacctt caagaacgca tgttcaaggc tcttggtttc   1500
tcaactgaag aagccaatga ccagtttggt ttccttcttg aagccatgga ctatggtttc   1560
ccaccacacg gtggtttggc tatcgggctt gaccgttttg tcatgttgct tgctggagaa   1620
gaaaatatcc gtgaagtcat tgcctttcct aagaacaaca aggcaactga cccaatgaca   1680
caagctccat caacagtcgc tctcaaacaa ctagaggaac tcagcttaca agtagaagaa   1740
gatgaaacaa acaaaacgaa t                                             1761

<210>   4418
<211>   587
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aspartyl-tRNA synthetase (aspS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903965 (0.E+01)

<400>   4418
Met Lys Arg Ser Met Tyr Ala Gly Arg Val Arg Glu Glu His Ile Gly 
1               5                   10                  15      

Gln Glu Ile Thr Leu Lys Gly Trp Val Gly Arg Arg Arg Asp Leu Gly 
            20                  25                  30          

Gly Leu Ile Phe Ile Asp Leu Arg Asp Arg Glu Gly Ile Met Gln Leu 
        35                  40                  45              

Val Ile Asn Pro Glu Lys Val Ser Ala Glu Val Met Ala Thr Ala Glu 
    50                  55                  60                  

Ser Leu Arg Ser Glu Phe Val Ile Glu Val Thr Gly Gln Val Ala Ala 
65                  70                  75                  80  

Arg Glu Gln Ala Asn Asp Lys Leu Pro Thr Gly Ala Val Glu Leu Asn 
                85                  90                  95      

Val Thr Ala Leu Ile Val Leu Asn Thr Ala Lys Thr Thr Pro Phe Glu 
            100                 105                 110         

Ile Lys Asp Gly Ile Glu Ala Asn Asp Asp Thr Arg Leu Arg Tyr Arg 
        115                 120                 125             

Tyr Leu Asp Leu Arg Arg Pro Glu Met Leu Glu Asn Leu Lys Leu Arg 
    130                 135                 140                 

Ala Lys Val Thr His Ser Ile Arg Asn Tyr Leu Asp Glu Leu Glu Phe 

145                 150                 155                 160 

Ile Asp Val Glu Thr Pro Phe Leu Ser Lys Ser Thr Pro Glu Gly Ala 
                165                 170                 175     

Arg Asp Tyr Leu Val Pro Ser Arg Val Asn Lys Gly His Phe Tyr Ala 
            180                 185                 190         

Leu Pro Gln Ser Pro Gln Ile Thr Lys Gln Leu Leu Met Asn Ala Gly 
        195                 200                 205             

Phe Asp Arg Tyr Tyr Gln Ile Val Lys Cys Phe Arg Asp Glu Asp Leu 
    210                 215                 220                 

Arg Gly Asp Arg Gln Pro Glu Phe Thr Gln Val Asp Leu Glu Thr Ser 
225                 230                 235                 240 

Phe Leu Thr Glu Gln Glu Ile Gln Asp Ile Thr Glu Ser Leu Ile Ala 
                245                 250                 255     

Arg Val Met Lys Glu Thr Lys Gly Ile Glu Val Thr Leu Pro Phe Pro 
            260                 265                 270         

Arg Met Lys Tyr Asp Asp Ala Met Ala Leu Tyr Gly Ser Asp Lys Pro 
        275                 280                 285             

Asp Thr Arg Phe Asp Met Leu Leu Gln Asp Leu Thr Glu Val Val Arg 
    290                 295                 300                 

Gly Val Asp Phe Lys Val Phe Ser Glu Ala Pro Ala Val Lys Ala Ile 
305                 310                 315                 320 

Val Val Thr Gly Ala Ala Asp Asn Tyr Ser Arg Lys Asp Ile Asp Lys 
                325                 330                 335     

Met Thr Glu Val Ala Lys Gln Tyr Gly Ala Lys Gly Leu Ala Trp Val 
            340                 345                 350         

Lys Val Val Asp Gly Glu Leu Asn Gly Pro Val Ala Lys Phe Leu Thr 
        355                 360                 365             

Gly Ile Gln Glu Glu Leu Thr Thr Ala Leu Val Leu Glu Asp Lys Asp 
    370                 375                 380                 

Leu Val Leu Phe Val Ala Asp Thr Leu Glu Val Ala Asn Ala Thr Leu 
385                 390                 395                 400 

Gly Ala Leu Arg Gly Arg Ile Ala Lys Glu Leu Gly Leu Ile Asp Asn 
                405                 410                 415     

Asp Lys Phe Asn Phe Leu Trp Val Val Asp Trp Pro Met Phe Glu Trp 
            420                 425                 430         

Ser Glu Glu Glu Gly Arg Tyr Met Ser Ala His His Pro Phe Thr Leu 
        435                 440                 445             

Pro Gln Glu Glu Thr Ala His Glu Leu Glu Gly Asp Leu Ala Lys Val 
    450                 455                 460                 

Arg Ala Ile Ala Tyr Asp Ile Val Leu Asn Gly Tyr Glu Leu Gly Gly 
465                 470                 475                 480 

Gly Ser Leu Arg Ile Asn Gln Lys Asp Leu Gln Glu Arg Met Phe Lys 
                485                 490                 495     

Ala Leu Gly Phe Ser Thr Glu Glu Ala Asn Asp Gln Phe Gly Phe Leu 
            500                 505                 510         

Leu Glu Ala Met Asp Tyr Gly Phe Pro Pro His Gly Gly Leu Ala Ile 
        515                 520                 525             

Gly Leu Asp Arg Phe Val Met Leu Leu Ala Gly Glu Glu Asn Ile Arg 
    530                 535                 540                 

Glu Val Ile Ala Phe Pro Lys Asn Asn Lys Ala Thr Asp Pro Met Thr 
545                 550                 555                 560 

Gln Ala Pro Ser Thr Val Ala Leu Lys Gln Leu Glu Glu Leu Ser Leu 
                565                 570                 575     

Gln Val Glu Glu Asp Glu Thr Asn Lys Thr Asn 
            580                 585         

<210>   4419
<211>   189
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4419
atgaaaatca aagagcaaac taggaagcta gccgcaggtt gctcaaaaca ctgttttgag   60
gttgtggata gaactgacga agtcagctca aaacatggtt ttgaggttgt agatgaaact   120
gacgaagtca gtaaccatac atacggtaag gcgacgctga cgtggtttga agagattttc   180
gaagagtat                                                           189

<210>   4420
<211>   63
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4420
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Gly Phe Glu Val Val Asp Glu Thr Asp Glu Val Ser Asn His Thr Tyr 
        35                  40                  45              

Gly Lys Ala Thr Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu Tyr 
    50                  55                  60              

<210>   4421
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4421
atgaacttca ccggactctt ttattttgaa tttttgcctg ctttacgctt ttcagcgatt   60
tcggctgcct ttcgaggcaa gacaatttcc gttatg                             96

<210>   4422
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4422
Met Asn Phe Thr Gly Leu Phe Tyr Phe Glu Phe Leu Pro Ala Leu Arg 
1               5                   10                  15      

Phe Ser Ala Ile Ser Ala Ala Phe Arg Gly Lys Thr Ile Ser Val Met 
            20                  25                  30          


<210>   4423
<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4423
atgaaacgag taattttatt agcagtgatt caggcagtcg ttctattttt catcattgga   60
gcgctagctt atgccttcaa aggcgatttc ttctataact atctagcagt tgtctttgct   120
cctattgcag gtgtactgcg ttttgggacg gcttacataa cggaaattgt cttgcctcga   180
aaggcagccg aaatcgctga aaagcgtaaa gcaggcaaaa attcaaaa                228

<210>   4424
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903966 (1.E-37)

<400>   4424
Met Lys Arg Val Ile Leu Leu Ala Val Ile Gln Ala Val Val Leu Phe 
1               5                   10                  15      

Phe Ile Ile Gly Ala Leu Ala Tyr Ala Phe Lys Gly Asp Phe Phe Tyr 
            20                  25                  30          

Asn Tyr Leu Ala Val Val Phe Ala Pro Ile Ala Gly Val Leu Arg Phe 
        35                  40                  45              

Gly Thr Ala Tyr Ile Thr Glu Ile Val Leu Pro Arg Lys Ala Ala Glu 
    50                  55                  60                  

Ile Ala Glu Lys Arg Lys Ala Gly Lys Asn Ser Lys 
65                  70                  75      

<210>   4425
<211>   639
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4425
atgaaattac ttaaaaacct tggctggatt cttctagccc ttctatcctt tttatttatc   60
tatggcttta ttcaggggct cgcgactgcg tcgcttgctt taggcgcttc accctatgct   120
gttactctac tctatgtggc cttggctgga gtatatgtgt acggcattta caaatggtat   180
cagaaggctc ctgttcatat tgagaagagc ggctttaatc gatttatttg gcttcctgtc   240
ttggtttggt tcttatctct ggtcgttcaa ttcttcttgc cagatgatcc ttcagtaaat   300

cagcaaatag cgacagactt gaccttgtct caaccacttt tctcattctt tgctgtggtt   360
atttttgctc ctttgacgga agagattgtt tttagaggga tgttagcacg ctatctcttt   420
cctaagcagg acaatagtaa acgaaccctg atttttcttc tggtatctag tcttctattt   480
gccttgattc attttccagg tgatgtgcaa caattttttg tctattttag ccttggtttt   540
agtttgggtt tggcttacat tagcagaaaa ggtctggtct acagtatttc tcttcacgct   600
ttgaataatt tagtcggctt tttgatgatt ctcatgcta                          639

<210>   4426
<211>   213
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903967 (e-118)

<400>   4426
Met Lys Leu Leu Lys Asn Leu Gly Trp Ile Leu Leu Ala Leu Leu Ser 
1               5                   10                  15      

Phe Leu Phe Ile Tyr Gly Phe Ile Gln Gly Leu Ala Thr Ala Ser Leu 
            20                  25                  30          

Ala Leu Gly Ala Ser Pro Tyr Ala Val Thr Leu Leu Tyr Val Ala Leu 
        35                  40                  45              

Ala Gly Val Tyr Val Tyr Gly Ile Tyr Lys Trp Tyr Gln Lys Ala Pro 
    50                  55                  60                  

Val His Ile Glu Lys Ser Gly Phe Asn Arg Phe Ile Trp Leu Pro Val 
65                  70                  75                  80  

Leu Val Trp Phe Leu Ser Leu Val Val Gln Phe Phe Leu Pro Asp Asp 
                85                  90                  95      

Pro Ser Val Asn Gln Gln Ile Ala Thr Asp Leu Thr Leu Ser Gln Pro 
            100                 105                 110         

Leu Phe Ser Phe Phe Ala Val Val Ile Phe Ala Pro Leu Thr Glu Glu 
        115                 120                 125             

Ile Val Phe Arg Gly Met Leu Ala Arg Tyr Leu Phe Pro Lys Gln Asp 
    130                 135                 140                 

Asn Ser Lys Arg Thr Leu Ile Phe Leu Leu Val Ser Ser Leu Leu Phe 
145                 150                 155                 160 

Ala Leu Ile His Phe Pro Gly Asp Val Gln Gln Phe Phe Val Tyr Phe 
                165                 170                 175     

Ser Leu Gly Phe Ser Leu Gly Leu Ala Tyr Ile Ser Arg Lys Gly Leu 
            180                 185                 190         

Val Tyr Ser Ile Ser Leu His Ala Leu Asn Asn Leu Val Gly Phe Leu 
        195                 200                 205             

Met Ile Leu Met Leu 
    210             

<210>   4427
<211>   678
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4427
ttgggcatgt ttgtagggat gtttaaggca cgtgtcgaat cccacgaaat tattttagat   60
gtaaaagcct tgatgccatg gatatcagct atttgtttac tgataggttt cattagtatg   120
tttttgactt tcaatttctt aaagaaaagc agaaaatttc attctttgta tcaagaggaa   180
atggatgacg atctgaatga aacctattat gtgcaaatgt atcggaatct tgagtttgga   240
accattgctt ttaatattac aggtgtagcg attccattgg ctatttttat ttcattaagt   300
gaggtgatta tattgcatac aaaccctcaa acatttttcc tttctttctt actctttgtg   360
gtattcttag tcgctcaaaa atctcttttt aaaaccattg cgattgttcg tcagtttgat   420
ttggaatttt tcgctacacc aaaggatgtc ttgaactata taaattctta tgatgaaggg   480
gagcgtcagg ctaatttgga acagagtttt cgaattttat tccaattaca ccaatatgtc   540
ttaccagcct tatatatttt tcttattatc atttctttct tgacaggaga gattcagtta   600
ctagctttct tgcttgtagg agccatccat gtttatatca atgtgatgca gttacctatg   660
gtaaaacgtt atttcaaa                                                 678


<210>   4428
<211>   226
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903968 (e-126)

<400>   4428
Met Gly Met Phe Val Gly Met Phe Lys Ala Arg Val Glu Ser His Glu 
1               5                   10                  15      

Ile Ile Leu Asp Val Lys Ala Leu Met Pro Trp Ile Ser Ala Ile Cys 
            20                  25                  30          

Leu Leu Ile Gly Phe Ile Ser Met Phe Leu Thr Phe Asn Phe Leu Lys 
        35                  40                  45              

Lys Ser Arg Lys Phe His Ser Leu Tyr Gln Glu Glu Met Asp Asp Asp 
    50                  55                  60                  

Leu Asn Glu Thr Tyr Tyr Val Gln Met Tyr Arg Asn Leu Glu Phe Gly 
65                  70                  75                  80  

Thr Ile Ala Phe Asn Ile Thr Gly Val Ala Ile Pro Leu Ala Ile Phe 
                85                  90                  95      

Ile Ser Leu Ser Glu Val Ile Ile Leu His Thr Asn Pro Gln Thr Phe 
            100                 105                 110         

Phe Leu Ser Phe Leu Leu Phe Val Val Phe Leu Val Ala Gln Lys Ser 
        115                 120                 125             

Leu Phe Lys Thr Ile Ala Ile Val Arg Gln Phe Asp Leu Glu Phe Phe 
    130                 135                 140                 

Ala Thr Pro Lys Asp Val Leu Asn Tyr Ile Asn Ser Tyr Asp Glu Gly 
145                 150                 155                 160 

Glu Arg Gln Ala Asn Leu Glu Gln Ser Phe Arg Ile Leu Phe Gln Leu 
                165                 170                 175     

His Gln Tyr Val Leu Pro Ala Leu Tyr Ile Phe Leu Ile Ile Ile Ser 
            180                 185                 190         

Phe Leu Thr Gly Glu Ile Gln Leu Leu Ala Phe Leu Leu Val Gly Ala 
        195                 200                 205             

Ile His Val Tyr Ile Asn Val Met Gln Leu Pro Met Val Lys Arg Tyr 
    210                 215                 220                 

Phe Lys 
225     

<210>   4429
<211>   198
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4429
gtgatgaaca agtataaagt gatttattat gtagtggtca tagctttatt agtcagcgta   60
tttctactga ttgggatgga cctaagctgg tttaatccct atcaaagcga ccaatttgtt   120
tgggtctact ttgctctcat cccagtaatt gaatggattg aaaagaaatc caaaaatcta   180
gcaagtgaaa aaggagaa                                                 198

<210>   4430
<211>   66
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903969 (1.E-34)

<400>   4430
Met Met Asn Lys Tyr Lys Val Ile Tyr Tyr Val Val Val Ile Ala Leu 
1               5                   10                  15      

Leu Val Ser Val Phe Leu Leu Ile Gly Met Asp Leu Ser Trp Phe Asn 
            20                  25                  30          

Pro Tyr Gln Ser Asp Gln Phe Val Trp Val Tyr Phe Ala Leu Ile Pro 
        35                  40                  45              

Val Ile Glu Trp Ile Glu Lys Lys Ser Lys Asn Leu Ala Ser Glu Lys 
    50                  55                  60                  


Gly Glu 
65      

<210>   4431
<211>   213
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4431
gtgtgtaaca tgcaactaaa aaatcgtcta aaagagcttc gagctcgcga tggtctcaat   60
caaaccgacc tagccaaact ggcaggggtt tccagacaga ccattagcct actagaacgg   120
gatgagtaca ccccatccat tatcattgcc ctgaaaatat ctcaaatttt caacgaaaca   180
gtcgaatcgg tatttcgttt ggaggaggac gag                                213

<210>   4432
<211>   71
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903970 (1.E-34)

<400>   4432
Met Cys Asn Met Gln Leu Lys Asn Arg Leu Lys Glu Leu Arg Ala Arg 
1               5                   10                  15      

Asp Gly Leu Asn Gln Thr Asp Leu Ala Lys Leu Ala Gly Val Ser Arg 
            20                  25                  30          

Gln Thr Ile Ser Leu Leu Glu Arg Asp Glu Tyr Thr Pro Ser Ile Ile 
        35                  40                  45              

Ile Ala Leu Lys Ile Ser Gln Ile Phe Asn Glu Thr Val Glu Ser Val 
    50                  55                  60                  

Phe Arg Leu Glu Glu Asp Glu 
65                  70      

<210>   4433
<211>   465
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4433
atgatagata aagtggtcag gaacctactc ctgacctttt tcttttgcaa aatgacaaaa   60
atcataattt ttttgacaac tatacttgtc aaaaagaaaa agatatgtta caatgaattc   120
aagttaagaa ataggaagca gaaaggagtt ataatgtggg tactaggatt tatactattt   180
atgattttct tttattctaa taattctaaa aaaatcaaga aactagagaa taaaatcaaa   240
agacttgagc gaaaagagaa aggaaacgca gaaatgtcga gattattaca agaaatgatt   300
ggaaaggaac caattataac gggagtgtat attgggccag ataactggga agttgtggat   360
gttgatgagg aatgggtaaa gctacgacgt gtagataata cgggaaaaga aaaattcaag   420
ttgcaacgta ttgaggatat ccaaaccgtt gaatttgacg gagag                   465

<210>   4434
<211>   155
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903971 (2.E-76)

<400>   4434
Met Ile Asp Lys Val Val Arg Asn Leu Leu Leu Thr Phe Phe Phe Cys 
1               5                   10                  15      

Lys Met Thr Lys Ile Ile Ile Phe Leu Thr Thr Ile Leu Val Lys Lys 
            20                  25                  30          

Lys Lys Ile Cys Tyr Asn Glu Phe Lys Leu Arg Asn Arg Lys Gln Lys 
        35                  40                  45              

Gly Val Ile Met Trp Val Leu Gly Phe Ile Leu Phe Met Ile Phe Phe 
    50                  55                  60                  

Tyr Ser Asn Asn Ser Lys Lys Ile Lys Lys Leu Glu Asn Lys Ile Lys 
65                  70                  75                  80  

Arg Leu Glu Arg Lys Glu Lys Gly Asn Ala Glu Met Ser Arg Leu Leu 
                85                  90                  95      

Gln Glu Met Ile Gly Lys Glu Pro Ile Ile Thr Gly Val Tyr Ile Gly 
            100                 105                 110         

Pro Asp Asn Trp Glu Val Val Asp Val Asp Glu Glu Trp Val Lys Leu 
        115                 120                 125             

Arg Arg Val Asp Asn Thr Gly Lys Glu Lys Phe Lys Leu Gln Arg Ile 
    130                 135                 140                 

Glu Asp Ile Gln Thr Val Glu Phe Asp Gly Glu 
145                 150                 155 

<210>   4435
<211>   216
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   4435
gtggatagaa ctgacgaagt cagctcaaaa catggttttg aggttgtgga tagaactgac   60
gaagtcagct caaaacatgg ttttgaggtt gtggatagaa ctgacgaagt cagctcaaaa   120
catggttttg aggttgtaga tgaaactgac gaagtcagta accataccta cggcaaggtg   180
aagctgacgt ggtttgaaga gattttagaa gagtat                             216

<210>   4436
<211>   72
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4436
Met Asp Arg Thr Asp Glu Val Ser Ser Lys His Gly Phe Glu Val Val 
1               5                   10                  15      

Asp Arg Thr Asp Glu Val Ser Ser Lys His Gly Phe Glu Val Val Asp 
            20                  25                  30          

Arg Thr Asp Glu Val Ser Ser Lys His Gly Phe Glu Val Val Asp Glu 
        35                  40                  45              

Thr Asp Glu Val Ser Asn His Thr Tyr Gly Lys Val Lys Leu Thr Trp 
    50                  55                  60                  

Phe Glu Glu Ile Leu Glu Glu Tyr 
65                  70          

<210>   4437
<211>   1287
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4437
atgaaattac aaaaaccaaa aggaacgcag gatattttac ctgctgagtc tgctaagtgg   60
cagtacgttg agggctttgc ccgtgagatt ttcaaacgct acaactatgc agaagtgcgc   120
acgcctattt ttgagcatta cgaggttatc agtcgctctg tcggagatac aacggatatc   180
gtaaccaagg aaatgtacga tttttatgac aagggtgacc gtcatattac cctccgtcca   240
gaaggaactg cacccgttgt ccgttcctat gtggaaaata aacttttcgc cccagaagtg   300
caaaagccaa gcaagttcta ctacatggga cctatgttcc gttatgagcg tccacaggca   360
gggcgcttgc gccaattcca ccagattggt gttgagtgtt ttggctctag caatccagct   420
accgatgtgg aaacaatcgc tatggcagcc cattttttga aggaaatcgg tattcaaggt   480
gtcaaattgc acctcaacac tcttggaaat cctgagagcc gtgcagccta ccgccaagcc   540
ttgattgact atttgacacc gctcaaggag accttgtcta aggatagcca acgtcgcttg   600
gaggaaaatc ctcttcgtgt cttggactct aaggaaaaag aagacaaggt ggcagtagag   660
aatgcgccgt ctatcttgga ctttcttgat gaagaaagcc aagctcattt tgatgctgtg   720
cgtcagatgt tggaaaatct tggagtagat tacatcatcg ataccaatat ggtgcgtggt   780
ctggactact acaaccacac cattttcgag tttatcacag agattgaggg caatgacctg   840
accgtctgtg cgggtggtcg ctacgatggt ttggttgctt actttggagg ccctgaaact   900
gctggatttg gttttggact tggtgtagag cgcctgcttc tcatccttga aaagcaaggt   960
gtgaccctcc ctatcgaaaa cgccctagat gtctatatcg cagtcttggg cgaaggggca   1020
aatatcaagg ccttggaatt ggtacaggct cttcgccaac aaggtttcaa agcagagcgt   1080
gattacctca accgtaaact aaaagctcag ttcaagtcag ccgatgtctt tgcggctaag   1140
accctcatca ccctaggaga gagcgaagtc gaaagcggac aagtgacggt caagaacaac   1200
caaacccgag aagaagtgca agtgtcactt gagacaatca gccaaaactt ctcagaaatc   1260
tttgaaaaac taggatttta tactcaa                                       1287

<210>   4438
<211>   429
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   histidyl-tRNA synthetase (hisS)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903972 (0.E+01)

<400>   4438
Met Lys Leu Gln Lys Pro Lys Gly Thr Gln Asp Ile Leu Pro Ala Glu 
1               5                   10                  15      

Ser Ala Lys Trp Gln Tyr Val Glu Gly Phe Ala Arg Glu Ile Phe Lys 
            20                  25                  30          

Arg Tyr Asn Tyr Ala Glu Val Arg Thr Pro Ile Phe Glu His Tyr Glu 
        35                  40                  45              

Val Ile Ser Arg Ser Val Gly Asp Thr Thr Asp Ile Val Thr Lys Glu 
    50                  55                  60                  

Met Tyr Asp Phe Tyr Asp Lys Gly Asp Arg His Ile Thr Leu Arg Pro 
65                  70                  75                  80  

Glu Gly Thr Ala Pro Val Val Arg Ser Tyr Val Glu Asn Lys Leu Phe 
                85                  90                  95      

Ala Pro Glu Val Gln Lys Pro Ser Lys Phe Tyr Tyr Met Gly Pro Met 
            100                 105                 110         

Phe Arg Tyr Glu Arg Pro Gln Ala Gly Arg Leu Arg Gln Phe His Gln 
        115                 120                 125             

Ile Gly Val Glu Cys Phe Gly Ser Ser Asn Pro Ala Thr Asp Val Glu 
    130                 135                 140                 

Thr Ile Ala Met Ala Ala His Phe Leu Lys Glu Ile Gly Ile Gln Gly 
145                 150                 155                 160 

Val Lys Leu His Leu Asn Thr Leu Gly Asn Pro Glu Ser Arg Ala Ala 
                165                 170                 175     

Tyr Arg Gln Ala Leu Ile Asp Tyr Leu Thr Pro Leu Lys Glu Thr Leu 
            180                 185                 190         

Ser Lys Asp Ser Gln Arg Arg Leu Glu Glu Asn Pro Leu Arg Val Leu 
        195                 200                 205             

Asp Ser Lys Glu Lys Glu Asp Lys Val Ala Val Glu Asn Ala Pro Ser 
    210                 215                 220                 

Ile Leu Asp Phe Leu Asp Glu Glu Ser Gln Ala His Phe Asp Ala Val 
225                 230                 235                 240 

Arg Gln Met Leu Glu Asn Leu Gly Val Asp Tyr Ile Ile Asp Thr Asn 
                245                 250                 255     

Met Val Arg Gly Leu Asp Tyr Tyr Asn His Thr Ile Phe Glu Phe Ile 
            260                 265                 270         

Thr Glu Ile Glu Gly Asn Asp Leu Thr Val Cys Ala Gly Gly Arg Tyr 
        275                 280                 285             

Asp Gly Leu Val Ala Tyr Phe Gly Gly Pro Glu Thr Ala Gly Phe Gly 
    290                 295                 300                 

Phe Gly Leu Gly Val Glu Arg Leu Leu Leu Ile Leu Glu Lys Gln Gly 
305                 310                 315                 320 

Val Thr Leu Pro Ile Glu Asn Ala Leu Asp Val Tyr Ile Ala Val Leu 
                325                 330                 335     

Gly Glu Gly Ala Asn Ile Lys Ala Leu Glu Leu Val Gln Ala Leu Arg 
            340                 345                 350         

Gln Gln Gly Phe Lys Ala Glu Arg Asp Tyr Leu Asn Arg Lys Leu Lys 
        355                 360                 365             

Ala Gln Phe Lys Ser Ala Asp Val Phe Ala Ala Lys Thr Leu Ile Thr 
    370                 375                 380                 

Leu Gly Glu Ser Glu Val Glu Ser Gly Gln Val Thr Val Lys Asn Asn 
385                 390                 395                 400 

Gln Thr Arg Glu Glu Val Gln Val Ser Leu Glu Thr Ile Ser Gln Asn 
                405                 410                 415     

Phe Ser Glu Ile Phe Glu Lys Leu Gly Phe Tyr Thr Gln 
            420                 425                 

<210>   4439
<211>   1245
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4439
atgaaactat tgtttagaaa tccagcttat agaattttga ctttatcacg cttcttcaat   60
gcttttggtg tttcgatttt caacctggtc tttatcgtct atgcatcgac cttgtcacaa   120
gcatcttttg ctgttgctat ggcgaatatt gtcatgattc ttccgaccct ctttacagtt   180
tttgcaggga ttcgggcaga ttacacgagg gacaaggtca aatggatggt ctatagcggt   240
ttgtttcagg cggttctatt ttttctagca gccctagttg ttcagcaagc tagtctcttt   300
gccttttcta gcctgtgttt gatcaatgtc attagtgata tcatcagtga ttttgcaggt   360
ggcctgcgta tgcctcttat taaggaaaaa gtagctgaag atgatctgat ggaggcttat   420
tctttttcac agttcatcac ctatatttca gctattggtg gtcaagcttt cggagtctgg   480
ctcttagctc tatcggtcaa caatttttct ctcgttgcgg gaatcaatgc ctgctttttc   540
ctagtatcag ccactatcct ctttttagga aaaagcaaat tgagcctgtc aatgtcatct   600
gctgatggtg aaaacttaaa aaatgagaag ctttctatca aagaccagtt cctaacaatt   660
taccgaaatt tacgtctcgt ttttcttaaa agtggacaga aaaactttgg ttttatgctc   720
tttgctgtct tgcttattaa ttccttgggt ggcgctttgg gtggaattta taatatcttc   780
tttttgagcc attctctctt gaatttttct tatacagagg cactatttat caatcaattc   840
tgtgttttag tatcagtcat catcagtagc cttacgggca atgattattt tgggaagcag   900
tccttgccta gattgatgat gtgggagacc gtaggactta gtctagttgg tttggctaat   960
ttattcaatc aagtcgtgct tggtttgcta tttctcttct ttactctgta tgtgtctggt   1020
aaagttcaac caaagattag tgccatgctc atgaaaaatc tagctccaga ggttctagct   1080
cgtactagta attttttagg tctattgttt accttatcca tacctgtggg aacagcttgt   1140
ttttcactag tagccgtatg gaatatacag ttgacttgga tgctatttgt tggtctttcc   1200
ttgctagcta tttttttgac aattcttaat ctcaaaaatg atatc                   1245

<210>   4440
<211>   415
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903973 (0.E+01)

<400>   4440
Met Lys Leu Leu Phe Arg Asn Pro Ala Tyr Arg Ile Leu Thr Leu Ser 
1               5                   10                  15      

Arg Phe Phe Asn Ala Phe Gly Val Ser Ile Phe Asn Leu Val Phe Ile 
            20                  25                  30          

Val Tyr Ala Ser Thr Leu Ser Gln Ala Ser Phe Ala Val Ala Met Ala 
        35                  40                  45              

Asn Ile Val Met Ile Leu Pro Thr Leu Phe Thr Val Phe Ala Gly Ile 
    50                  55                  60                  

Arg Ala Asp Tyr Thr Arg Asp Lys Val Lys Trp Met Val Tyr Ser Gly 
65                  70                  75                  80  

Leu Phe Gln Ala Val Leu Phe Phe Leu Ala Ala Leu Val Val Gln Gln 
                85                  90                  95      

Ala Ser Leu Phe Ala Phe Ser Ser Leu Cys Leu Ile Asn Val Ile Ser 
            100                 105                 110         

Asp Ile Ile Ser Asp Phe Ala Gly Gly Leu Arg Met Pro Leu Ile Lys 
        115                 120                 125             

Glu Lys Val Ala Glu Asp Asp Leu Met Glu Ala Tyr Ser Phe Ser Gln 
    130                 135                 140                 

Phe Ile Thr Tyr Ile Ser Ala Ile Gly Gly Gln Ala Phe Gly Val Trp 
145                 150                 155                 160 

Leu Leu Ala Leu Ser Val Asn Asn Phe Ser Leu Val Ala Gly Ile Asn 
                165                 170                 175     

Ala Cys Phe Phe Leu Val Ser Ala Thr Ile Leu Phe Leu Gly Lys Ser 
            180                 185                 190         

Lys Leu Ser Leu Ser Met Ser Ser Ala Asp Gly Glu Asn Leu Lys Asn 
        195                 200                 205             

Glu Lys Leu Ser Ile Lys Asp Gln Phe Leu Thr Ile Tyr Arg Asn Leu 
    210                 215                 220                 

Arg Leu Val Phe Leu Lys Ser Gly Gln Lys Asn Phe Gly Phe Met Leu 
225                 230                 235                 240 

Phe Ala Val Leu Leu Ile Asn Ser Leu Gly Gly Ala Leu Gly Gly Ile 
                245                 250                 255     

Tyr Asn Ile Phe Phe Leu Ser His Ser Leu Leu Asn Phe Ser Tyr Thr 
            260                 265                 270         

Glu Ala Leu Phe Ile Asn Gln Phe Cys Val Leu Val Ser Val Ile Ile 
        275                 280                 285             

Ser Ser Leu Thr Gly Asn Asp Tyr Phe Gly Lys Gln Ser Leu Pro Arg 
    290                 295                 300                 

Leu Met Met Trp Glu Thr Val Gly Leu Ser Leu Val Gly Leu Ala Asn 
305                 310                 315                 320 

Leu Phe Asn Gln Val Val Leu Gly Leu Leu Phe Leu Phe Phe Thr Leu 
                325                 330                 335     

Tyr Val Ser Gly Lys Val Gln Pro Lys Ile Ser Ala Met Leu Met Lys 
            340                 345                 350         

Asn Leu Ala Pro Glu Val Leu Ala Arg Thr Ser Asn Phe Leu Gly Leu 
        355                 360                 365             

Leu Phe Thr Leu Ser Ile Pro Val Gly Thr Ala Cys Phe Ser Leu Val 
    370                 375                 380                 

Ala Val Trp Asn Ile Gln Leu Thr Trp Met Leu Phe Val Gly Leu Ser 
385                 390                 395                 400 

Leu Leu Ala Ile Phe Leu Thr Ile Leu Asn Leu Lys Asn Asp Ile 
                405                 410                 415 

<210>   4441
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4441
ttgccagaca tttccattag aaaatcagat ttacgtacca tttctcgtac atatctagta   60
aaaagagaaa cagataaaaa tggagaactg actgaaaata aattgagttc a            111

<210>   4442
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4442
Met Pro Asp Ile Ser Ile Arg Lys Ser Asp Leu Arg Thr Ile Ser Arg 
1               5                   10                  15      

Thr Tyr Leu Val Lys Arg Glu Thr Asp Lys Asn Gly Glu Leu Thr Glu 
            20                  25                  30          

Asn Lys Leu Ser Ser 
        35          

<210>   4443
<211>   483
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4443
atgaagagca tagatgaaag ggtagactta acagcagagg aaggaaaagt ccttcatgat   60
tatttgtttt ctaccgagat ctggggaatc tatgaactca atttattttc agtcagttct   120
ccatttttat ctgtttctct ttttactaga tatgtacgag aaatggtacg taaatctgat   180
tttctaatgg aaatgtctgg caatcgaaac ctttttcata ctatactatt gaatggcttt   240
ttagctagta ttgagtgtga agaatttacc aatgcctatt attttaaacg tgttatcgaa   300
gagcatttct acaaggaaaa tgagacctat ttccgaattg tttatctgtg ggcagaaggt   360
ctccttgata gcaagcaagg tagagtcaag gaaggccaga aaaagatgga ggatgctgtc   420
cgtatttttg agatgcttgg ctgtaataaa tctgccgaat actatagaaa aactcccgat   480
tct                                                                 483

<210>   4444
<211>   161
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   rgg protein, putative

<400>   4444
Met Lys Ser Ile Asp Glu Arg Val Asp Leu Thr Ala Glu Glu Gly Lys 
1               5                   10                  15      

Val Leu His Asp Tyr Leu Phe Ser Thr Glu Ile Trp Gly Ile Tyr Glu 
            20                  25                  30          

Leu Asn Leu Phe Ser Val Ser Ser Pro Phe Leu Ser Val Ser Leu Phe 
        35                  40                  45              

Thr Arg Tyr Val Arg Glu Met Val Arg Lys Ser Asp Phe Leu Met Glu 
    50                  55                  60                  

Met Ser Gly Asn Arg Asn Leu Phe His Thr Ile Leu Leu Asn Gly Phe 
65                  70                  75                  80  

Leu Ala Ser Ile Glu Cys Glu Glu Phe Thr Asn Ala Tyr Tyr Phe Lys 
                85                  90                  95      

Arg Val Ile Glu Glu His Phe Tyr Lys Glu Asn Glu Thr Tyr Phe Arg 
            100                 105                 110         

Ile Val Tyr Leu Trp Ala Glu Gly Leu Leu Asp Ser Lys Gln Gly Arg 
        115                 120                 125             

Val Lys Glu Gly Gln Lys Lys Met Glu Asp Ala Val Arg Ile Phe Glu 
    130                 135                 140                 

Met Leu Gly Cys Asn Lys Ser Ala Glu Tyr Tyr Arg Lys Thr Pro Asp 
145                 150                 155                 160 

Ser 
    

<210>   4445
<211>   848
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4445
atggagcaga ttggaaaagt ctttagacaa ttacgagagt caagaaatat ctcactgaga   60
caagcaaccg gaggacaatt ttcgccgtct atgttgtccc gttttgaaac aggtcagagt   120
gagctttcgg tggaaaagtt tctatttgct ctggaaaata tatctgccag tgtggaggag   180
atcctctttc tggcaagagg tttccagtat gatacagatt ctgagttgag aaaagaaatt   240
acagatgtct tggaaccaaa gaatatagca cctcttgagg acttatatcg cagggagtat   300
aaaagcatgc ccattctcac aacaaacaga aacatattct aaatgccatt attatcaagt   360
cttatatgaa gagcatagat gaaagggtag acttaacagc agaggaagga aaagtccttc   420
atgattattt gttttctacc gagatctggg gaatctatga actcaattta ttttcagtca   480
gttctccatt tttatctgtt tctcttttta ctagatatgt acgagaaatg gtacgtaaat   540
ctgattttct aatggaaatg tctggcaatc gaaacctttt tcatactata ctattgaatg   600
gctttttagc tagtattgag tgtgaagaat ttaccaatgc ctattatttt aaacgtgtta   660
tcgaagagca tttctacaag gaaaatgaga cctatttccg aattgtttat ctgtgggcag   720
aaggtctcct tgatagcaag caaggtagag tcaaggaagg ccagaaaaag atggaggatg   780
ctgtccgtat ttttgagatg cttggctgta ataaatctgc cgaatactat agaaaaactc   840
ccgattct                                                            848

<210>   4446
<211>   113
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, FRAMESHIFT

<400>   4446
Met Glu Gln Ile Gly Lys Val Phe Arg Gln Leu Arg Glu Ser Arg Asn 
1               5                   10                  15      

Ile Ser Leu Arg Gln Ala Thr Gly Gly Gln Phe Ser Pro Ser Met Leu 
            20                  25                  30          

Ser Arg Phe Glu Thr Gly Gln Ser Glu Leu Ser Val Glu Lys Phe Leu 
        35                  40                  45              

Phe Ala Leu Glu Asn Ile Ser Ala Ser Val Glu Glu Ile Leu Phe Leu 
    50                  55                  60                  

Ala Arg Gly Phe Gln Tyr Asp Thr Asp Ser Glu Leu Arg Lys Glu Ile 
65                  70                  75                  80  

Thr Asp Val Leu Glu Pro Lys Asn Ile Ala Pro Leu Glu Asp Leu Tyr 
                85                  90                  95      

Arg Arg Glu Tyr Lys Ser Met Pro Ile Leu Thr Thr Asn Arg Asn Ile 
            100                 105                 110         


Phe 
    

<210>   4447
<211>   132
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4447
gtgataaata tcctctattt tctcataatt ctgacaattt ggcaagtttt tgatgaattt   60
tctgaaaaat atgataaaat gaagaaaata cggaatcaag gggaagtcta tggagcagat   120
tggaaaagtc tt                                                       132

<210>   4448
<211>   44
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   4448
Met Ile Asn Ile Leu Tyr Phe Leu Ile Ile Leu Thr Ile Trp Gln Val 
1               5                   10                  15      

Phe Asp Glu Phe Ser Glu Lys Tyr Asp Lys Met Lys Lys Ile Arg Asn 
            20                  25                  30          

Gln Gly Glu Val Tyr Gly Ala Asp Trp Lys Ser Leu 
        35                  40                  

<210>   4449
<211>   339
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4449
atgagagacg atatcaaaat caatgaccgt gctttggcct tgcaagacca aattatcgaa   60
aaactagaga aagtttttga tacagatgtg gaattggatg tttacaatct aggtctgatt   120
tatgaaatca atctggatga aacggggctc tgcaagattg tcatgacctt caccgatact   180
gcctgtgatt gcgccgaaag cctgcctatt gaaatcgtgg caggtctgaa acaaatcgag   240
ggtatcaaag atatcaaggt tgaagttacc tggtcgcctg cttggaaaat cacacgaatc   300
agtcgctatg gccgtattgc ccttggacta ccacctcgt                          339

<210>   4450
<211>   113
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903975 (2.E-61)

<400>   4450
Met Arg Asp Asp Ile Lys Ile Asn Asp Arg Ala Leu Ala Leu Gln Asp 
1               5                   10                  15      

Gln Ile Ile Glu Lys Leu Glu Lys Val Phe Asp Thr Asp Val Glu Leu 
            20                  25                  30          

Asp Val Tyr Asn Leu Gly Leu Ile Tyr Glu Ile Asn Leu Asp Glu Thr 
        35                  40                  45              

Gly Leu Cys Lys Ile Val Met Thr Phe Thr Asp Thr Ala Cys Asp Cys 
    50                  55                  60                  

Ala Glu Ser Leu Pro Ile Glu Ile Val Ala Gly Leu Lys Gln Ile Glu 
65                  70                  75                  80  

Gly Ile Lys Asp Ile Lys Val Glu Val Thr Trp Ser Pro Ala Trp Lys 
                85                  90                  95      

Ile Thr Arg Ile Ser Arg Tyr Gly Arg Ile Ala Leu Gly Leu Pro Pro 
            100                 105                 110         

Arg 
    

<210>   4451
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4451
atgaaaatca aagggcaaac tagaaaacta gccgcaggtt gctcaaaaca ctgttttgaa   60
gttatggata gaactgacga agtcagctca aaacactgtt ttgaggttgt ggatagaact   120
gacgaagtca gctcaaaaca ctgttttgag gttgtggata gaactgacga agtcagccca   180
aaacactgtt ttgaggttgt ggatagaact gacgaagtca gtaaccatac ctacggcaag   240
gcgacgttga cg                                                       252

<210>   4452
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4452
Met Lys Ile Lys Gly Gln Thr Arg Lys Leu Ala Ala Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Met Asp Arg Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Cys Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys 
        35                  40                  45              

Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Pro Lys His Cys Phe 
    50                  55                  60                  

Glu Val Val Asp Arg Thr Asp Glu Val Ser Asn His Thr Tyr Gly Lys 
65                  70                  75                  80  

Ala Thr Leu Thr 
                

<210>   4453
<211>   1701
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4453
atgactgaat tagataaacg tcaccgcagt agcatttatg acagcatggt taaatcacct   60
aaccgtgcta tgcttcgtgc gactggtatg acagataagg actttgaaac atcgattgtg   120
ggagtgattt cgacttgggc ggaaaataca ccatgtaaca ttcacttgca tgatttcggg   180
aaactggcta aagaaggtgt caaatctgca ggcgcttggc ctgtacagtt tggaaccatt   240
accgtagcgg acgggatcgc tatgggaacg cctggtatgc gtttctctct aacatctcgt   300
gacatcatcg cggactccat cgaggcggct atgagtggtc acaacgtgga tgccttcgtc   360
gctatcggtg gctgtgacaa gaacatgcct ggatctatga ttgctattgc taatatggat   420
atcccagcta ttttcgccta tggtggaact attgcaccgg gaaatcttga tggtaaagat   480
atcgacttgg tttctgtctt tgaaggtatc ggaaaatgga accacggtga catgacagct   540
gaggacgtga aacgtcttga atgtaatgcc tgccctggcc ctggtggttg tggtggtatg   600
tatactgcta ataccatggc aactgctatc gaagttctag ggatgagttt gccagggtca   660
tcctctcacc cagctgaatc agctgataag aaagaagata tcgaagcagc aggacgtgct   720
gttgttaaga tgttggaact tggtctcaaa ccatcagata tcttgactcg tgaagccttt   780
gaagatgcta tcactgtaac gatggctctc ggtggttcta caaacgccac tcttcacttg   840
ctcgccattg cccatgccgc aaatgttgac ttgtcacttg aggacttcaa tacgattcaa   900
gaacgtgtgc ctcacttggc cgacttgaaa ccatctggtc agtatgtctt ccaagacctc   960
tacgaagtcg gtggtgtccc tgcggttatg aagtatttgt tggcaaatgg tttccttcac   1020
ggagatcgca tcacatgtac tggtaagact gtagctgaaa acttggctga ctttgcagac   1080
ttgactccag gccaaaaagt tatcatgcca cttgaaaatc caaaacgtgc ggatggtccg   1140
cttatcatct tgaacgggaa ccttgctcct gacggtgcag ttgccaaggt atcaggtgtt   1200
aaagtgcgtc gtcacgttgg gccagctaag gtctttgact cagaagaaga tgcgattcag   1260
gccgttctga cagatgaaat cgttgatggc gatgtagtcg ttgttcgttt tgttggacct   1320
aaaggtggtc ctggtatgcc tgagatgcta tcactttctt caatgattgt tggtaaaggt   1380
cagggagata aggtggccct cttgacggac ggacgtttct ctggtggtac ttatggtctg   1440
gttgttggac atatcgctcc tgaagctcag gatggtggac caattgccta tctccgtacc   1500
ggcgatatcg ttacggttga ccaagatacc aaagaaattt ctatggccgt atccgaagaa   1560
gaacttgaaa aacgcaaggc agaaacaacc ttgccaccac tttacagccg tggtgtcctc   1620
ggtaaatatg cccacatcgt atcatctgct tcacgcggag ccgtgacaga cttctggaat   1680
atggacaagt caggtaaaaa a                                             1701

<210>   4454
<211>   567
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dihydroxy-acid dehydratase (ilvD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903976 (0.E+01)

<400>   4454
Met Thr Glu Leu Asp Lys Arg His Arg Ser Ser Ile Tyr Asp Ser Met 
1               5                   10                  15      

Val Lys Ser Pro Asn Arg Ala Met Leu Arg Ala Thr Gly Met Thr Asp 
            20                  25                  30          

Lys Asp Phe Glu Thr Ser Ile Val Gly Val Ile Ser Thr Trp Ala Glu 
        35                  40                  45              

Asn Thr Pro Cys Asn Ile His Leu His Asp Phe Gly Lys Leu Ala Lys 
    50                  55                  60                  

Glu Gly Val Lys Ser Ala Gly Ala Trp Pro Val Gln Phe Gly Thr Ile 
65                  70                  75                  80  

Thr Val Ala Asp Gly Ile Ala Met Gly Thr Pro Gly Met Arg Phe Ser 
                85                  90                  95      

Leu Thr Ser Arg Asp Ile Ile Ala Asp Ser Ile Glu Ala Ala Met Ser 
            100                 105                 110         

Gly His Asn Val Asp Ala Phe Val Ala Ile Gly Gly Cys Asp Lys Asn 
        115                 120                 125             

Met Pro Gly Ser Met Ile Ala Ile Ala Asn Met Asp Ile Pro Ala Ile 
    130                 135                 140                 

Phe Ala Tyr Gly Gly Thr Ile Ala Pro Gly Asn Leu Asp Gly Lys Asp 
145                 150                 155                 160 

Ile Asp Leu Val Ser Val Phe Glu Gly Ile Gly Lys Trp Asn His Gly 
                165                 170                 175     

Asp Met Thr Ala Glu Asp Val Lys Arg Leu Glu Cys Asn Ala Cys Pro 
            180                 185                 190         

Gly Pro Gly Gly Cys Gly Gly Met Tyr Thr Ala Asn Thr Met Ala Thr 
        195                 200                 205             

Ala Ile Glu Val Leu Gly Met Ser Leu Pro Gly Ser Ser Ser His Pro 
    210                 215                 220                 

Ala Glu Ser Ala Asp Lys Lys Glu Asp Ile Glu Ala Ala Gly Arg Ala 
225                 230                 235                 240 

Val Val Lys Met Leu Glu Leu Gly Leu Lys Pro Ser Asp Ile Leu Thr 
                245                 250                 255     

Arg Glu Ala Phe Glu Asp Ala Ile Thr Val Thr Met Ala Leu Gly Gly 
            260                 265                 270         

Ser Thr Asn Ala Thr Leu His Leu Leu Ala Ile Ala His Ala Ala Asn 
        275                 280                 285             

Val Asp Leu Ser Leu Glu Asp Phe Asn Thr Ile Gln Glu Arg Val Pro 
    290                 295                 300                 

His Leu Ala Asp Leu Lys Pro Ser Gly Gln Tyr Val Phe Gln Asp Leu 
305                 310                 315                 320 

Tyr Glu Val Gly Gly Val Pro Ala Val Met Lys Tyr Leu Leu Ala Asn 
                325                 330                 335     

Gly Phe Leu His Gly Asp Arg Ile Thr Cys Thr Gly Lys Thr Val Ala 
            340                 345                 350         

Glu Asn Leu Ala Asp Phe Ala Asp Leu Thr Pro Gly Gln Lys Val Ile 
        355                 360                 365             

Met Pro Leu Glu Asn Pro Lys Arg Ala Asp Gly Pro Leu Ile Ile Leu 
    370                 375                 380                 

Asn Gly Asn Leu Ala Pro Asp Gly Ala Val Ala Lys Val Ser Gly Val 
385                 390                 395                 400 

Lys Val Arg Arg His Val Gly Pro Ala Lys Val Phe Asp Ser Glu Glu 
                405                 410                 415     

Asp Ala Ile Gln Ala Val Leu Thr Asp Glu Ile Val Asp Gly Asp Val 
            420                 425                 430         

Val Val Val Arg Phe Val Gly Pro Lys Gly Gly Pro Gly Met Pro Glu 
        435                 440                 445             

Met Leu Ser Leu Ser Ser Met Ile Val Gly Lys Gly Gln Gly Asp Lys 
    450                 455                 460                 

Val Ala Leu Leu Thr Asp Gly Arg Phe Ser Gly Gly Thr Tyr Gly Leu 
465                 470                 475                 480 

Val Val Gly His Ile Ala Pro Glu Ala Gln Asp Gly Gly Pro Ile Ala 
                485                 490                 495     

Tyr Leu Arg Thr Gly Asp Ile Val Thr Val Asp Gln Asp Thr Lys Glu 
            500                 505                 510         

Ile Ser Met Ala Val Ser Glu Glu Glu Leu Glu Lys Arg Lys Ala Glu 
        515                 520                 525             

Thr Thr Leu Pro Pro Leu Tyr Ser Arg Gly Val Leu Gly Lys Tyr Ala 
    530                 535                 540                 

His Ile Val Ser Ser Ala Ser Arg Gly Ala Val Thr Asp Phe Trp Asn 
545                 550                 555                 560 

Met Asp Lys Ser Gly Lys Lys 
                565         

<210>   4455
<211>   930
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4455
atgatgagaa gtacgaaaga attacggcat gtatatagag acttcctttt agaggctaat   60
caaagtgatt ctgatatagt agtcttagaa gccgatttgt caagttcgat ggctactaat   120
aatcttgaaa aggactttgg agaccgttat gtgaatgttg ggattatgga agcagaaatg   180
gtcggccttg cagcaggctt gtctattcag gggtttagac cttatcttca tacatttggt   240
ccttttgctt cacgaagagt atttgatcaa ttatttattt ctcttggata cgcacaattg   300
gatgccactg tgattggatc agatgcagga gtaacggcag agatgaatgg tggaacacat   360
atgccatttg aagaaattgg attgttacgt ttaattccta aatcaatcat tttcgaagca   420
actgatgata tccaatttcg tgaaatattg aaccagacat tagacttaaa aggactaaaa   480
tatattcgaa caattagaaa agctccagtt cctgtgtatc aaggtggaga agatttttct   540
aaaggctaca ttgagttaag gcatggtgaa gatcttgtaa tcgttgcttc tggcataatg   600
gttgctccaa gtattcgagt tgcagatgaa ctgtctaaat taggttattc agtaggtgtg   660
atagatttat ttagaatcaa accgatacca gaacagataa aaacaatgtt aagtggaaaa   720
actatattta ctgtagaaaa ccacaatcag ataggtggaa ttggcagtgc tttatgtgaa   780
ttattctctg atgatggaat aacaaaaatt catcggatgg gtgttcaaga aagattcggt   840
caagtaggga aaatggatta tcttcttaat gagtatggtt tgagtgaatc gaatataaaa   900
gagaaggttc tagaaattta taatgcaaga                                    930

<210>   4456
<211>   310
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transketolase, C-terminal subunit
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903977 (e-172)

<400>   4456
Met Met Arg Ser Thr Lys Glu Leu Arg His Val Tyr Arg Asp Phe Leu 
1               5                   10                  15      

Leu Glu Ala Asn Gln Ser Asp Ser Asp Ile Val Val Leu Glu Ala Asp 
            20                  25                  30          

Leu Ser Ser Ser Met Ala Thr Asn Asn Leu Glu Lys Asp Phe Gly Asp 
        35                  40                  45              

Arg Tyr Val Asn Val Gly Ile Met Glu Ala Glu Met Val Gly Leu Ala 
    50                  55                  60                  

Ala Gly Leu Ser Ile Gln Gly Phe Arg Pro Tyr Leu His Thr Phe Gly 
65                  70                  75                  80  

Pro Phe Ala Ser Arg Arg Val Phe Asp Gln Leu Phe Ile Ser Leu Gly 
                85                  90                  95      

Tyr Ala Gln Leu Asp Ala Thr Val Ile Gly Ser Asp Ala Gly Val Thr 
            100                 105                 110         

Ala Glu Met Asn Gly Gly Thr His Met Pro Phe Glu Glu Ile Gly Leu 
        115                 120                 125             


Leu Arg Leu Ile Pro Lys Ser Ile Ile Phe Glu Ala Thr Asp Asp Ile 
    130                 135                 140                 

Gln Phe Arg Glu Ile Leu Asn Gln Thr Leu Asp Leu Lys Gly Leu Lys 
145                 150                 155                 160 

Tyr Ile Arg Thr Ile Arg Lys Ala Pro Val Pro Val Tyr Gln Gly Gly 
                165                 170                 175     

Glu Asp Phe Ser Lys Gly Tyr Ile Glu Leu Arg His Gly Glu Asp Leu 
            180                 185                 190         

Val Ile Val Ala Ser Gly Ile Met Val Ala Pro Ser Ile Arg Val Ala 
        195                 200                 205             

Asp Glu Leu Ser Lys Leu Gly Tyr Ser Val Gly Val Ile Asp Leu Phe 
    210                 215                 220                 

Arg Ile Lys Pro Ile Pro Glu Gln Ile Lys Thr Met Leu Ser Gly Lys 
225                 230                 235                 240 

Thr Ile Phe Thr Val Glu Asn His Asn Gln Ile Gly Gly Ile Gly Ser 
                245                 250                 255     

Ala Leu Cys Glu Leu Phe Ser Asp Asp Gly Ile Thr Lys Ile His Arg 
            260                 265                 270         

Met Gly Val Gln Glu Arg Phe Gly Gln Val Gly Lys Met Asp Tyr Leu 
        275                 280                 285             

Leu Asn Glu Tyr Gly Leu Ser Glu Ser Asn Ile Lys Glu Lys Val Leu 
    290                 295                 300                 

Glu Ile Tyr Asn Ala Arg 
305                 310 

<210>   4457
<211>   855
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4457
atgattttaa gtaaaaatag agaagatggg ttaagaaaat ttgcgactaa catccgatta   60
aatactctta gaacattgaa tcatcttgga ttcggacatt acggaggaag tctgtctatc   120
gtagaagttt tagcggtgct ttatggtgaa ataatgccaa tgactccaga aatatttgca   180
gcacgagata gagattattt catattatca aaaggtcacg gaggaccagc tctatacagt   240
acactctatt tgaatggttt ctttgacaaa gaattcttat attctttaaa tacaaatgga   300
accaaattac cgtctcatcc tgatagaaat ctaacgccag gcatagatat gacaacgggc   360
tctttaggac aaggaattag tgttgcaact ggacttgcat atggtcagag aataagaaag   420
agtccctttt atacttacgc tattgttgga gatggtgagt taaatgaggg acaatgttgg   480
gaggctatac agtttgcttc tcatcaacag ttatccaact taattgtatt tgttgatgat   540
aacaaaaaac aattagatgg ttttacaaag gatatttgta atccaggtga tttcgtagaa   600
aaattttcag catttggatt tgaatccatt agggtcaagg gttcagatat tagagaaatt   660
tatgaaggga ttgtccaatt aaaacagtca aataattcat cacctaagtg cattgtatta   720
gatactatta aaggtcaagg ggttcaagag ctggaagaaa tgaaatccaa tcatcatctt   780
cgccctactg tagaggagaa acaaatgtta acttcagttg tagaaagatt aagtcaggaa   840
ttggaggaaa cagaa                                                    855

<210>   4458
<211>   285
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transketolase, N-terminal subunit
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903978 (e-165)

<400>   4458
Met Ile Leu Ser Lys Asn Arg Glu Asp Gly Leu Arg Lys Phe Ala Thr 
1               5                   10                  15      

Asn Ile Arg Leu Asn Thr Leu Arg Thr Leu Asn His Leu Gly Phe Gly 
            20                  25                  30          

His Tyr Gly Gly Ser Leu Ser Ile Val Glu Val Leu Ala Val Leu Tyr 
        35                  40                  45              

Gly Glu Ile Met Pro Met Thr Pro Glu Ile Phe Ala Ala Arg Asp Arg 
    50                  55                  60                  

Asp Tyr Phe Ile Leu Ser Lys Gly His Gly Gly Pro Ala Leu Tyr Ser 
65                  70                  75                  80  

Thr Leu Tyr Leu Asn Gly Phe Phe Asp Lys Glu Phe Leu Tyr Ser Leu 
                85                  90                  95      

Asn Thr Asn Gly Thr Lys Leu Pro Ser His Pro Asp Arg Asn Leu Thr 
            100                 105                 110         

Pro Gly Ile Asp Met Thr Thr Gly Ser Leu Gly Gln Gly Ile Ser Val 
        115                 120                 125             

Ala Thr Gly Leu Ala Tyr Gly Gln Arg Ile Arg Lys Ser Pro Phe Tyr 
    130                 135                 140                 

Thr Tyr Ala Ile Val Gly Asp Gly Glu Leu Asn Glu Gly Gln Cys Trp 
145                 150                 155                 160 

Glu Ala Ile Gln Phe Ala Ser His Gln Gln Leu Ser Asn Leu Ile Val 
                165                 170                 175     

Phe Val Asp Asp Asn Lys Lys Gln Leu Asp Gly Phe Thr Lys Asp Ile 
            180                 185                 190         

Cys Asn Pro Gly Asp Phe Val Glu Lys Phe Ser Ala Phe Gly Phe Glu 
        195                 200                 205             

Ser Ile Arg Val Lys Gly Ser Asp Ile Arg Glu Ile Tyr Glu Gly Ile 
    210                 215                 220                 

Val Gln Leu Lys Gln Ser Asn Asn Ser Ser Pro Lys Cys Ile Val Leu 
225                 230                 235                 240 

Asp Thr Ile Lys Gly Gln Gly Val Gln Glu Leu Glu Glu Met Lys Ser 
                245                 250                 255     

Asn His His Leu Arg Pro Thr Val Glu Glu Lys Gln Met Leu Thr Ser 
            260                 265                 270         

Val Val Glu Arg Leu Ser Gln Glu Leu Glu Glu Thr Glu 
        275                 280                 285 

<210>   4459
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4459
atgatgaagt tcatattgga tattgttagt acaccagcta ttttagtagc tttaattgca   60
atcttaggat tagttcttca gaagaagaaa ttacctgata ttattaaagg tggaattaag   120
acctttgttg gtttcttagt tgtatctggt ggtgcaggaa ttgtacaaaa ttctttaaat   180
ccatttggta ccatgtttga gcatgctttt catttatctg gcgttgtgcc gaataatgaa   240
gcaattgtag ctgtagcttt aacaacatat ggctcagcta ctgcaatgat tatgtttgca   300
ggcatggtgt tcaatatctt aatcgctcgt tttactcgat ttaaatatat ttttttaaca   360
gggcaccaca ctctatatat ggcatgtatg attgcggtca ttttatcagt tgctggcttt   420
actagcttgc ctctcatctt actaggagga ttagcactcg gtattattat gagtatttcc   480
ccagcatttg tgcaaaaata tatggttcaa ttaactggaa atgacaaggt agctttaggt   540
catttcagtt ctttgggata ttggttgagt ggttttactg gtagccttat cggtgacaaa   600
tcaaaatcaa cagaggacat taaatttcca aagagtttag cttttttacg tgatagtact   660
gttagtatta ctttatccat ggcagttatt tacattattg tagctatctt tgcagggtca   720
gaatatatag aaaaagaaat cagtagtggt acaagtggtc tagtttatgc tttacaatta   780
gcaggtcaat ttgcagcagg ggtatttgtt attttagcag gtgttcgcct tattttgggc   840
gaaattgttc cagcctttaa aggtatttca gagcgtcttg tacctaattc aaaacctgct   900
ttggattgtc cgattgttta tacttatgca cccaatgcag ttctaattgg atttatctct   960
agttttgttg gtggtttagt aagtatggta attatgattg cttcaggaac ggttgttatc   1020
ttaccaggtg ttgtgcctca tttcttctgt ggagcgactg caggtgtcat tgggaatgca   1080
tctggtggtg ttcgtggagc cactattgga gcatttttac aaggtatttt aatcagtttt   1140
cttccagtct ttttaatgcc agttttggga ggacttggtt tccaaggatc aactttctca   1200
gatgcagatt ttggtctatc aggaattatt ttaggaatgt taaatcaatt tggctcacaa   1260
gcaggcattg tgattggtct tgttcttatt ctagcagtta tgtttggagt atcctttatt   1320
aaaaagccat ctgcaacgga ggaa                                          1344

<210>   4460
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIC component, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903979 (0.E+01)

<400>   4460

Met Met Lys Phe Ile Leu Asp Ile Val Ser Thr Pro Ala Ile Leu Val 
1               5                   10                  15      

Ala Leu Ile Ala Ile Leu Gly Leu Val Leu Gln Lys Lys Lys Leu Pro 
            20                  25                  30          

Asp Ile Ile Lys Gly Gly Ile Lys Thr Phe Val Gly Phe Leu Val Val 
        35                  40                  45              

Ser Gly Gly Ala Gly Ile Val Gln Asn Ser Leu Asn Pro Phe Gly Thr 
    50                  55                  60                  

Met Phe Glu His Ala Phe His Leu Ser Gly Val Val Pro Asn Asn Glu 
65                  70                  75                  80  

Ala Ile Val Ala Val Ala Leu Thr Thr Tyr Gly Ser Ala Thr Ala Met 
                85                  90                  95      

Ile Met Phe Ala Gly Met Val Phe Asn Ile Leu Ile Ala Arg Phe Thr 
            100                 105                 110         

Arg Phe Lys Tyr Ile Phe Leu Thr Gly His His Thr Leu Tyr Met Ala 
        115                 120                 125             

Cys Met Ile Ala Val Ile Leu Ser Val Ala Gly Phe Thr Ser Leu Pro 
    130                 135                 140                 

Leu Ile Leu Leu Gly Gly Leu Ala Leu Gly Ile Ile Met Ser Ile Ser 
145                 150                 155                 160 

Pro Ala Phe Val Gln Lys Tyr Met Val Gln Leu Thr Gly Asn Asp Lys 
                165                 170                 175     

Val Ala Leu Gly His Phe Ser Ser Leu Gly Tyr Trp Leu Ser Gly Phe 
            180                 185                 190         

Thr Gly Ser Leu Ile Gly Asp Lys Ser Lys Ser Thr Glu Asp Ile Lys 
        195                 200                 205             

Phe Pro Lys Ser Leu Ala Phe Leu Arg Asp Ser Thr Val Ser Ile Thr 
    210                 215                 220                 

Leu Ser Met Ala Val Ile Tyr Ile Ile Val Ala Ile Phe Ala Gly Ser 
225                 230                 235                 240 

Glu Tyr Ile Glu Lys Glu Ile Ser Ser Gly Thr Ser Gly Leu Val Tyr 
                245                 250                 255     

Ala Leu Gln Leu Ala Gly Gln Phe Ala Ala Gly Val Phe Val Ile Leu 
            260                 265                 270         

Ala Gly Val Arg Leu Ile Leu Gly Glu Ile Val Pro Ala Phe Lys Gly 
        275                 280                 285             

Ile Ser Glu Arg Leu Val Pro Asn Ser Lys Pro Ala Leu Asp Cys Pro 
    290                 295                 300                 

Ile Val Tyr Thr Tyr Ala Pro Asn Ala Val Leu Ile Gly Phe Ile Ser 
305                 310                 315                 320 

Ser Phe Val Gly Gly Leu Val Ser Met Val Ile Met Ile Ala Ser Gly 
                325                 330                 335     

Thr Val Val Ile Leu Pro Gly Val Val Pro His Phe Phe Cys Gly Ala 
            340                 345                 350         

Thr Ala Gly Val Ile Gly Asn Ala Ser Gly Gly Val Arg Gly Ala Thr 
        355                 360                 365             

Ile Gly Ala Phe Leu Gln Gly Ile Leu Ile Ser Phe Leu Pro Val Phe 
    370                 375                 380                 

Leu Met Pro Val Leu Gly Gly Leu Gly Phe Gln Gly Ser Thr Phe Ser 
385                 390                 395                 400 

Asp Ala Asp Phe Gly Leu Ser Gly Ile Ile Leu Gly Met Leu Asn Gln 
                405                 410                 415     

Phe Gly Ser Gln Ala Gly Ile Val Ile Gly Leu Val Leu Ile Leu Ala 
            420                 425                 430         

Val Met Phe Gly Val Ser Phe Ile Lys Lys Pro Ser Ala Thr Glu Glu 
        435                 440                 445             


<210>   4461
<211>   282
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4461
atgttaaaaa ttggtacagc ttgtggttca ggattaggtt caagttttat ggtacagatg   60
aatattgaat ctgtattgag tgatttgaat gtttcggatg tagaagttga acattatgat   120
ttaggtggag cagatccaaa tgcagctgat atttggattg ttggtcgtga tctagctgat   180
tcagctagtc atcttggaga tgttcgtatc ttaaatagta ttattgatat ggatgaacta   240
cgagaattaa ttactaaact ttgtgaagaa aaaggactta ta                      282

<210>   4462
<211>   94
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIB component, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903980 (1.E-49)

<400>   4462
Met Leu Lys Ile Gly Thr Ala Cys Gly Ser Gly Leu Gly Ser Ser Phe 
1               5                   10                  15      

Met Val Gln Met Asn Ile Glu Ser Val Leu Ser Asp Leu Asn Val Ser 
            20                  25                  30          

Asp Val Glu Val Glu His Tyr Asp Leu Gly Gly Ala Asp Pro Asn Ala 
        35                  40                  45              

Ala Asp Ile Trp Ile Val Gly Arg Asp Leu Ala Asp Ser Ala Ser His 
    50                  55                  60                  

Leu Gly Asp Val Arg Ile Leu Asn Ser Ile Ile Asp Met Asp Glu Leu 
65                  70                  75                  80  

Arg Glu Leu Ile Thr Lys Leu Cys Glu Glu Lys Gly Leu Ile 
                85                  90                  

<210>   4463
<211>   2028
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4463
atgtttgatt atagagcact agttattttg atgactttga tggatcattg tgagctatca   60
ttatatgaat tatctgttaa ggtgagctta cctataaagg aagtcaaaga aggaatagat   120
tatttagtgc cttatctagc taataaaggg atagtgctgg ataaaaagca aggtcgctat   180
agtttatcaa atcgtacgaa gcagtctttg acagatatta ttaagtcgga tgaattggtt   240
ttaccaaagt cgactcgctt agctttaatc tatctttaca ctttttgccg attagatttt   300
atatcgaata gtcattacca agactttttg aaagtaagta agaatacaac cttatctgat   360
attcaatcat taagaaagat tatgttagat aatgatttgg agctagggta cagtagagca   420
aaaggttata ctttacacgg ttcagagtgg aataagcacc gcttagcttt tcaaatggtt   480
agtgagttgc tggaatcctc catagggatt tggggtttgg attatgtttt atccagttgg   540

gggtattcat taacttatga tttgattgat caggtagtta aagattatta tgagaagcta   600
cagctagtac ctattgttaa tcaattaaaa gtttaccttt tcggtttagt attcattctg   660
tgtaggtatc aaagggatgt tgaaagagta tgtctttcag agacattagt atctcctgtt   720
attcaagata taaccactat tttattggat acagtggttg atttgggaat tatagatacg   780
gtgttttctg aggatgatta tcgctatatc accgttttat tatcaagttg ctttgaaggt   840
gaagtagatg ttgctccggt ttactttaat caattaacag aggctattat aagtagaatg   900
gaagatattt ctttgttaca ttttaaacaa agggaaggat tgagagaaaa tcttcgccgc   960
caccttatac cggcttacta tagattaaag ttcggcctac ctagttcaaa tgaatatgta   1020
ttgcatgtta aagaacatta tcctgattta tttgaattag tcaaagattc tttgatgccc   1080
ttgatggacg ctattgacaa tcccatacct gatagtgaaa cagcatattt tgttatccat   1140
ttcggaggtt atttaaagaa agcagatact ttgcctcaaa aatggtataa agcagcaatc   1200
atttgtccta atggtgttag ttcttcattg atgttaaaag agaatctatt agcattattt   1260
cctcaaattg agtttatagg aacctcaaag attgatgatt tacaggtgaa agctagtagt   1320
gactatgata tggttttttc taccataaag gtggagacag aaaagccaaa ttatctagtt   1380
tcggttatga tgactgaaga gcaagcaata caactagtag aactagtgtt aaaagatttt   1440
ccgaatttag agtatggaga ttttgagatt gaacaaatcc tgaatattgt caaaagatat   1500
ggaattatta cacaagaatt ggaattaaga ttggcgttaa agaattatct ttaccaaaaa   1560
aatgatagaa aggaaattgt accagtgcta gaacaactta ttaccaaaga aacctatcag   1620
gttagttcgc aaaaattagg atggaaggag gcgattcgtt tagcagctaa accgcttttg   1680
gatcaagata agataactga gaactaccct gaggcaatga ttcaaaaagt agaagagttt   1740
ggacctttta ttaatttagg gaagggagta gcaattcctc acgctcggcc agatgaaggt   1800
gtgaatgaaa taggaatgtc aatgttagtt ttggaagaac cgatttattt attggataat   1860
ccagaacaag aggtaagatt gttgatttgt attgcagcca ttgataatga gagtcattta   1920
aaggctttgt cacatttaac aacaatttta agagataaaa atcatgttca aactttaata   1980
tcatcaaaaa actatgatga cattaaaatg ataattaaac aggaggat                2028

<210>   4464
<211>   676
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, BglG family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903981 (0.E+01)

<400>   4464
Met Phe Asp Tyr Arg Ala Leu Val Ile Leu Met Thr Leu Met Asp His 
1               5                   10                  15      

Cys Glu Leu Ser Leu Tyr Glu Leu Ser Val Lys Val Ser Leu Pro Ile 
            20                  25                  30          

Lys Glu Val Lys Glu Gly Ile Asp Tyr Leu Val Pro Tyr Leu Ala Asn 
        35                  40                  45              

Lys Gly Ile Val Leu Asp Lys Lys Gln Gly Arg Tyr Ser Leu Ser Asn 
    50                  55                  60                  

Arg Thr Lys Gln Ser Leu Thr Asp Ile Ile Lys Ser Asp Glu Leu Val 
65                  70                  75                  80  

Leu Pro Lys Ser Thr Arg Leu Ala Leu Ile Tyr Leu Tyr Thr Phe Cys 
                85                  90                  95      

Arg Leu Asp Phe Ile Ser Asn Ser His Tyr Gln Asp Phe Leu Lys Val 
            100                 105                 110         

Ser Lys Asn Thr Thr Leu Ser Asp Ile Gln Ser Leu Arg Lys Ile Met 
        115                 120                 125             

Leu Asp Asn Asp Leu Glu Leu Gly Tyr Ser Arg Ala Lys Gly Tyr Thr 
    130                 135                 140                 

Leu His Gly Ser Glu Trp Asn Lys His Arg Leu Ala Phe Gln Met Val 
145                 150                 155                 160 

Ser Glu Leu Leu Glu Ser Ser Ile Gly Ile Trp Gly Leu Asp Tyr Val 
                165                 170                 175     

Leu Ser Ser Trp Gly Tyr Ser Leu Thr Tyr Asp Leu Ile Asp Gln Val 
            180                 185                 190         

Val Lys Asp Tyr Tyr Glu Lys Leu Gln Leu Val Pro Ile Val Asn Gln 
        195                 200                 205             

Leu Lys Val Tyr Leu Phe Gly Leu Val Phe Ile Leu Cys Arg Tyr Gln 
    210                 215                 220                 

Arg Asp Val Glu Arg Val Cys Leu Ser Glu Thr Leu Val Ser Pro Val 
225                 230                 235                 240 

Ile Gln Asp Ile Thr Thr Ile Leu Leu Asp Thr Val Val Asp Leu Gly 
                245                 250                 255     

Ile Ile Asp Thr Val Phe Ser Glu Asp Asp Tyr Arg Tyr Ile Thr Val 
            260                 265                 270         

Leu Leu Ser Ser Cys Phe Glu Gly Glu Val Asp Val Ala Pro Val Tyr 
        275                 280                 285             

Phe Asn Gln Leu Thr Glu Ala Ile Ile Ser Arg Met Glu Asp Ile Ser 
    290                 295                 300                 

Leu Leu His Phe Lys Gln Arg Glu Gly Leu Arg Glu Asn Leu Arg Arg 
305                 310                 315                 320 

His Leu Ile Pro Ala Tyr Tyr Arg Leu Lys Phe Gly Leu Pro Ser Ser 
                325                 330                 335     

Asn Glu Tyr Val Leu His Val Lys Glu His Tyr Pro Asp Leu Phe Glu 
            340                 345                 350         

Leu Val Lys Asp Ser Leu Met Pro Leu Met Asp Ala Ile Asp Asn Pro 
        355                 360                 365             

Ile Pro Asp Ser Glu Thr Ala Tyr Phe Val Ile His Phe Gly Gly Tyr 
    370                 375                 380                 

Leu Lys Lys Ala Asp Thr Leu Pro Gln Lys Trp Tyr Lys Ala Ala Ile 
385                 390                 395                 400 

Ile Cys Pro Asn Gly Val Ser Ser Ser Leu Met Leu Lys Glu Asn Leu 
                405                 410                 415     

Leu Ala Leu Phe Pro Gln Ile Glu Phe Ile Gly Thr Ser Lys Ile Asp 
            420                 425                 430         

Asp Leu Gln Val Lys Ala Ser Ser Asp Tyr Asp Met Val Phe Ser Thr 
        435                 440                 445             

Ile Lys Val Glu Thr Glu Lys Pro Asn Tyr Leu Val Ser Val Met Met 
    450                 455                 460                 

Thr Glu Glu Gln Ala Ile Gln Leu Val Glu Leu Val Leu Lys Asp Phe 
465                 470                 475                 480 

Pro Asn Leu Glu Tyr Gly Asp Phe Glu Ile Glu Gln Ile Leu Asn Ile 
                485                 490                 495     


Val Lys Arg Tyr Gly Ile Ile Thr Gln Glu Leu Glu Leu Arg Leu Ala 
            500                 505                 510         

Leu Lys Asn Tyr Leu Tyr Gln Lys Asn Asp Arg Lys Glu Ile Val Pro 
        515                 520                 525             

Val Leu Glu Gln Leu Ile Thr Lys Glu Thr Tyr Gln Val Ser Ser Gln 
    530                 535                 540                 

Lys Leu Gly Trp Lys Glu Ala Ile Arg Leu Ala Ala Lys Pro Leu Leu 
545                 550                 555                 560 

Asp Gln Asp Lys Ile Thr Glu Asn Tyr Pro Glu Ala Met Ile Gln Lys 
                565                 570                 575     

Val Glu Glu Phe Gly Pro Phe Ile Asn Leu Gly Lys Gly Val Ala Ile 
            580                 585                 590         

Pro His Ala Arg Pro Asp Glu Gly Val Asn Glu Ile Gly Met Ser Met 
        595                 600                 605             

Leu Val Leu Glu Glu Pro Ile Tyr Leu Leu Asp Asn Pro Glu Gln Glu 
    610                 615                 620                 

Val Arg Leu Leu Ile Cys Ile Ala Ala Ile Asp Asn Glu Ser His Leu 
625                 630                 635                 640 

Lys Ala Leu Ser His Leu Thr Thr Ile Leu Arg Asp Lys Asn His Val 
                645                 650                 655     

Gln Thr Leu Ile Ser Ser Lys Asn Tyr Asp Asp Ile Lys Met Ile Ile 
            660                 665                 670         

Lys Gln Glu Asp 
        675     

<210>   4465
<211>   1005
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4465
atgactgaaa aactaatcaa ttcaaaacca aatggtgtat tcgcattgat tctcattgag   60
ttgacaatcg tacttggtat ctttatattt ataatggggg ttggttcgga aaacattttt   120
ggaattatta tcggaccttt actaatcgta attgcaggtc tagctcatgc tggtttaaaa   180
gttgtcaaac ctcaagaagc tctggttctg acactctttg gtaactatac aggtaccatc   240
aaagaacctg gcttttactt tgtcaatccc ttcagcgtag cagtcaaccc tgcaaaccac   300
actcgacttg gacaaagtgg tgatgttagc acaaaatctc cttttttagg agctaaatca   360
tcaaatgaca atgatgtaaa tcttgaaatt ggcaagaaac agatttccct caaagtcatg   420
accttgagca attctcgtca aaaaatcaat gattgcttag gaaaccctgt agaaatcggt   480
atcgcggtaa cttggagagt tgtcgatacc gctaaggcag tcttcaacgt tgataactac   540
aaagaatatc tttcattgca atgtgatagc gccctccgta atattgtccg catctatcct   600
tacgatgtgt ctcctaatgt ggatactacg ggtgatgggc aagcagatga aggtagtctc   660
cgtggctcta gcgaaattgt tgctaaccgt attcgtgaag aaatccaaag tcgtgttgag   720
gatgctggct tggaaatcct tgaagcacgt atcacttacc tagcttatgc tccagaaatt   780
gctgccgtta tgcttcaacg ccaacaagca tctgccatta ttgatgcacg gaagatgatt   840
gtagatggtg ctgtaggaat ggttgaaatg gcactagaac ggctcaatga aggggaattg   900
gtagaacttg acgaagaacg aaaagctgcc atggtttcaa atctccttgt cgttctttgt   960
ggcaatcatg atgcacaacc aattgtcaac acaggaagcc tttac                   1005

<210>   4466
<211>   335
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903982 (0.E+01)

<400>   4466
Met Thr Glu Lys Leu Ile Asn Ser Lys Pro Asn Gly Val Phe Ala Leu 
1               5                   10                  15      

Ile Leu Ile Glu Leu Thr Ile Val Leu Gly Ile Phe Ile Phe Ile Met 
            20                  25                  30          

Gly Val Gly Ser Glu Asn Ile Phe Gly Ile Ile Ile Gly Pro Leu Leu 
        35                  40                  45              

Ile Val Ile Ala Gly Leu Ala His Ala Gly Leu Lys Val Val Lys Pro 
    50                  55                  60                  

Gln Glu Ala Leu Val Leu Thr Leu Phe Gly Asn Tyr Thr Gly Thr Ile 
65                  70                  75                  80  

Lys Glu Pro Gly Phe Tyr Phe Val Asn Pro Phe Ser Val Ala Val Asn 
                85                  90                  95      

Pro Ala Asn His Thr Arg Leu Gly Gln Ser Gly Asp Val Ser Thr Lys 
            100                 105                 110         

Ser Pro Phe Leu Gly Ala Lys Ser Ser Asn Asp Asn Asp Val Asn Leu 
        115                 120                 125             

Glu Ile Gly Lys Lys Gln Ile Ser Leu Lys Val Met Thr Leu Ser Asn 
    130                 135                 140                 

Ser Arg Gln Lys Ile Asn Asp Cys Leu Gly Asn Pro Val Glu Ile Gly 
145                 150                 155                 160 

Ile Ala Val Thr Trp Arg Val Val Asp Thr Ala Lys Ala Val Phe Asn 
                165                 170                 175     

Val Asp Asn Tyr Lys Glu Tyr Leu Ser Leu Gln Cys Asp Ser Ala Leu 
            180                 185                 190         

Arg Asn Ile Val Arg Ile Tyr Pro Tyr Asp Val Ser Pro Asn Val Asp 
        195                 200                 205             

Thr Thr Gly Asp Gly Gln Ala Asp Glu Gly Ser Leu Arg Gly Ser Ser 
    210                 215                 220                 

Glu Ile Val Ala Asn Arg Ile Arg Glu Glu Ile Gln Ser Arg Val Glu 
225                 230                 235                 240 

Asp Ala Gly Leu Glu Ile Leu Glu Ala Arg Ile Thr Tyr Leu Ala Tyr 
                245                 250                 255     

Ala Pro Glu Ile Ala Ala Val Met Leu Gln Arg Gln Gln Ala Ser Ala 
            260                 265                 270         

Ile Ile Asp Ala Arg Lys Met Ile Val Asp Gly Ala Val Gly Met Val 
        275                 280                 285             

Glu Met Ala Leu Glu Arg Leu Asn Glu Gly Glu Leu Val Glu Leu Asp 
    290                 295                 300                 

Glu Glu Arg Lys Ala Ala Met Val Ser Asn Leu Leu Val Val Leu Cys 
305                 310                 315                 320 

Gly Asn His Asp Ala Gln Pro Ile Val Asn Thr Gly Ser Leu Tyr 
                325                 330                 335 

<210>   4467
<211>   198
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4467
atggctgaag ctaaaaaaaa gcagatcccc cttcgactct caacaaagtt atacgctgca   60
ctcgcatcat gggcagaaga cgactttcgt tcagtcaatg ggcaaatcga atatctcctc   120
acagagtgtg tcaagcaacg gaagaaagac ggaaaatacg tatcagaaac cattgacgaa   180
ccatttgaga ttgatatt                                                 198

<210>   4468
<211>   66
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903983 (7.E-34)

<400>   4468
Met Ala Glu Ala Lys Lys Lys Gln Ile Pro Leu Arg Leu Ser Thr Lys 
1               5                   10                  15      

Leu Tyr Ala Ala Leu Ala Ser Trp Ala Glu Asp Asp Phe Arg Ser Val 
            20                  25                  30          

Asn Gly Gln Ile Glu Tyr Leu Leu Thr Glu Cys Val Lys Gln Arg Lys 
        35                  40                  45              

Lys Asp Gly Lys Tyr Val Ser Glu Thr Ile Asp Glu Pro Phe Glu Ile 
    50                  55                  60                  

Asp Ile 
65      

<210>   4469
<211>   180
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4469
atggcagtac ctgcacgtcg cacttcaaaa gcgaagaaaa acaaacgtcg tacacactac   60
aaagtaacag ctccatctgt aaactttgac gaaactactg gagattactc acgttctcac   120
cgtgtatcac ttaaaggata ctacaaagga cgtaaaatca ctaaagctgc atcagctgaa   180

<210>   4470
<211>   60
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L32 (rpmF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903984 (5.E-30)

<400>   4470
Met Ala Val Pro Ala Arg Arg Thr Ser Lys Ala Lys Lys Asn Lys Arg 
1               5                   10                  15      

Arg Thr His Tyr Lys Val Thr Ala Pro Ser Val Asn Phe Asp Glu Thr 
            20                  25                  30          

Thr Gly Asp Tyr Ser Arg Ser His Arg Val Ser Leu Lys Gly Tyr Tyr 
        35                  40                  45              

Lys Gly Arg Lys Ile Thr Lys Ala Ala Ser Ala Glu 
    50                  55                  60  

<210>   4471
<211>   147
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4471
atgcgcgtaa atattacact tgaacacaaa gaatctggtg aacgcttgta ccttacttct   60
aaaaacaaac gtaacactcc agaccgcctt caattgaaga aatactcacc aaaacttcgc   120
aaacacgttg tgtttacaga ggttaaa                                       147

<210>   4472
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L33 (rpmG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903985 (4.E-24)

<400>   4472
Met Arg Val Asn Ile Thr Leu Glu His Lys Glu Ser Gly Glu Arg Leu 
1               5                   10                  15      

Tyr Leu Thr Ser Lys Asn Lys Arg Asn Thr Pro Asp Arg Leu Gln Leu 
            20                  25                  30          

Lys Lys Tyr Ser Pro Lys Leu Arg Lys His Val Val Phe Thr Glu Val 
        35                  40                  45              

Lys 
    

<210>   4473
<211>   1863
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4473
atgaaaaaaa ctacaatatt atcattaact acagctgcgg ttattttagc agcatatgtc   60
cctaatgaac caatcctagc agatactcct agttcggaag taatcaaaga gactaaagtt   120
ggaagtatta ttcaacaaaa taatatcaaa tataaggttc taactgtaga aggtaacata   180
ggaactgttc aagtgggtaa tggagttact cctgtagagt ttgaagctgg tcaagatgga   240
aaaccattca cgattcctac aaaaatcaca gtaggtgata aagtatttac cgttactgaa   300
gtagctagtc aagcttttag ttattatcca gatgaaacag gtagaattgt ctactatcct   360
agctctatta ctatcccatc aagcataaaa aaaatacaaa aaaaaggctt ccatggaagt   420
aaagctaaaa ctattatttt tgacaaaggc agtcagctgg agaaaattga agatagagct   480
tttgattttt ctgaattaga agagattgaa ttgcctgcat ctctagaata tattggaaca   540
agtgcatttt cttttagtca aaaattgaaa aagctaacct tttcctcaag ttcaaaatta   600
gaattaatat cacatgaggc ttttgctaat ttatcaaatt tagagaaact aacattacca   660
aaatcggtta aaacattagg aagtaatcta tttagactca ctactagctt aaaacatgtt   720
gatgttgaag aaggaaatga atcgtttgcc tcagttgatg gtgttttgtt ttcaaaagat   780
aaaacccaat taatttatta tccaagtcaa aaaaatgacg aaagttataa aacgcctaag   840
gagacaaaag aacttgcatc atattcgttt aataaaaatt cttacttgaa aaaactcgaa   900
ttgaatgaag gtttagaaaa aatcggtact tttgcatttg cagatgcgat taaacttgaa   960
gaaattagct taccaaatag tttagaaact attgaacgtt tagcctttta cggtaattta   1020
gaattaaaag aacttatatt accagataat gttaaaaatt ttggtaaaca cgttatgaac   1080
ggtttaccaa aattaaaaag tttaacaatt ggtaataata tcaactcatt gccgtccttc   1140
ttcctaagtg gcgtcttaga ttcattaaag gaaattcata ttaagaataa aagtacagag   1200
ttttctgtga aaaaagatac atttgcaatt cctgaaactg ttaagttcta tgtaacatca   1260
gaacatataa aagatgttct taaatcaaat ttatctacta gtaatgatat cattgttgaa   1320
aaagtagata atataaaaca agaaactgat gtagctaaac ctaaaaagaa ttctaatcag   1380
ggagtagttg gttgggttaa agacaaaggt ttatggtatt acttaaacga atcaggttca   1440
atggctactg gttgggttaa agacaaaggt ttatggtatt acttaaacga atcaggttca   1500
atggctactg gttgggttaa agacaaaggc ttatggtact acttaaatga atcaggttca   1560
atggctactg gttgggttaa agacaaaggc ttatggtatt acttaaacga atcaggttca   1620
atggctactg gttgggttaa agacaaaggc ttatggtact acttaaatga atcaggttca   1680
atggctactg gttgggttaa agacaaaggc ttatggtatt acttaaatga atcaggttca   1740
atggctactg gttgggttac agtttctggt aaatggtact atacctataa ttcaggagat   1800
ttattagtaa acacgactac acccgatggc tatcgagtca atgctaacgg tgagtgggta   1860
gga                                                                 1863

<210>   4474
<211>   621
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline binding protein PcpA (pcpA)
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15903986 (0.E+01)

<400>   4474
Met Lys Lys Thr Thr Ile Leu Ser Leu Thr Thr Ala Ala Val Ile Leu 
1               5                   10                  15      

Ala Ala Tyr Val Pro Asn Glu Pro Ile Leu Ala Asp Thr Pro Ser Ser 
            20                  25                  30          

Glu Val Ile Lys Glu Thr Lys Val Gly Ser Ile Ile Gln Gln Asn Asn 
        35                  40                  45              

Ile Lys Tyr Lys Val Leu Thr Val Glu Gly Asn Ile Gly Thr Val Gln 
    50                  55                  60                  

Val Gly Asn Gly Val Thr Pro Val Glu Phe Glu Ala Gly Gln Asp Gly 
65                  70                  75                  80  

Lys Pro Phe Thr Ile Pro Thr Lys Ile Thr Val Gly Asp Lys Val Phe 
                85                  90                  95      

Thr Val Thr Glu Val Ala Ser Gln Ala Phe Ser Tyr Tyr Pro Asp Glu 
            100                 105                 110         

Thr Gly Arg Ile Val Tyr Tyr Pro Ser Ser Ile Thr Ile Pro Ser Ser 
        115                 120                 125             

Ile Lys Lys Ile Gln Lys Lys Gly Phe His Gly Ser Lys Ala Lys Thr 
    130                 135                 140                 

Ile Ile Phe Asp Lys Gly Ser Gln Leu Glu Lys Ile Glu Asp Arg Ala 
145                 150                 155                 160 

Phe Asp Phe Ser Glu Leu Glu Glu Ile Glu Leu Pro Ala Ser Leu Glu 
                165                 170                 175     

Tyr Ile Gly Thr Ser Ala Phe Ser Phe Ser Gln Lys Leu Lys Lys Leu 
            180                 185                 190         

Thr Phe Ser Ser Ser Ser Lys Leu Glu Leu Ile Ser His Glu Ala Phe 
        195                 200                 205             

Ala Asn Leu Ser Asn Leu Glu Lys Leu Thr Leu Pro Lys Ser Val Lys 
    210                 215                 220                 

Thr Leu Gly Ser Asn Leu Phe Arg Leu Thr Thr Ser Leu Lys His Val 
225                 230                 235                 240 

Asp Val Glu Glu Gly Asn Glu Ser Phe Ala Ser Val Asp Gly Val Leu 
                245                 250                 255     

Phe Ser Lys Asp Lys Thr Gln Leu Ile Tyr Tyr Pro Ser Gln Lys Asn 
            260                 265                 270         

Asp Glu Ser Tyr Lys Thr Pro Lys Glu Thr Lys Glu Leu Ala Ser Tyr 
        275                 280                 285             

Ser Phe Asn Lys Asn Ser Tyr Leu Lys Lys Leu Glu Leu Asn Glu Gly 
    290                 295                 300                 

Leu Glu Lys Ile Gly Thr Phe Ala Phe Ala Asp Ala Ile Lys Leu Glu 
305                 310                 315                 320 

Glu Ile Ser Leu Pro Asn Ser Leu Glu Thr Ile Glu Arg Leu Ala Phe 
                325                 330                 335     


Tyr Gly Asn Leu Glu Leu Lys Glu Leu Ile Leu Pro Asp Asn Val Lys 
            340                 345                 350         

Asn Phe Gly Lys His Val Met Asn Gly Leu Pro Lys Leu Lys Ser Leu 
        355                 360                 365             

Thr Ile Gly Asn Asn Ile Asn Ser Leu Pro Ser Phe Phe Leu Ser Gly 
    370                 375                 380                 

Val Leu Asp Ser Leu Lys Glu Ile His Ile Lys Asn Lys Ser Thr Glu 
385                 390                 395                 400 

Phe Ser Val Lys Lys Asp Thr Phe Ala Ile Pro Glu Thr Val Lys Phe 
                405                 410                 415     

Tyr Val Thr Ser Glu His Ile Lys Asp Val Leu Lys Ser Asn Leu Ser 
            420                 425                 430         

Thr Ser Asn Asp Ile Ile Val Glu Lys Val Asp Asn Ile Lys Gln Glu 
        435                 440                 445             

Thr Asp Val Ala Lys Pro Lys Lys Asn Ser Asn Gln Gly Val Val Gly 
    450                 455                 460                 

Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn Glu Ser Gly Ser 
465                 470                 475                 480 

Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn 
                485                 490                 495     

Glu Ser Gly Ser Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp 
            500                 505                 510         

Tyr Tyr Leu Asn Glu Ser Gly Ser Met Ala Thr Gly Trp Val Lys Asp 
        515                 520                 525             

Lys Gly Leu Trp Tyr Tyr Leu Asn Glu Ser Gly Ser Met Ala Thr Gly 
    530                 535                 540                 

Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn Glu Ser Gly Ser 
545                 550                 555                 560 

Met Ala Thr Gly Trp Val Lys Asp Lys Gly Leu Trp Tyr Tyr Leu Asn 
                565                 570                 575     

Glu Ser Gly Ser Met Ala Thr Gly Trp Val Thr Val Ser Gly Lys Trp 
            580                 585                 590         

Tyr Tyr Thr Tyr Asn Ser Gly Asp Leu Leu Val Asn Thr Thr Thr Pro 
        595                 600                 605             

Asp Gly Tyr Arg Val Asn Ala Asn Gly Glu Trp Val Gly 
    610                 615                 620     

<210>   4475
<211>   180
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4475
atggacttaa aatttgaagg ggttgattta gaatacaaaa aagctaaaaa caatcttcca   60
gagtctttct gggaaaccta ctcagcattt gcaaatacaa atggcgggaa aataattctc   120
gggatagatg aaaaaaacat tgacacctac caaagagtca atagactccc tgcgaaatta   180

<210>   4476
<211>   60
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein, fusion

<400>   4476
Met Asp Leu Lys Phe Glu Gly Val Asp Leu Glu Tyr Lys Lys Ala Lys 
1               5                   10                  15      

Asn Asn Leu Pro Glu Ser Phe Trp Glu Thr Tyr Ser Ala Phe Ala Asn 
            20                  25                  30          

Thr Asn Gly Gly Lys Ile Ile Leu Gly Ile Asp Glu Lys Asn Ile Asp 
        35                  40                  45              

Thr Tyr Gln Arg Val Asn Arg Leu Pro Ala Lys Leu 
    50                  55                  60  

<210>   4477
<211>   348
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4477
aattatgaag caagtaaaca attaactgat acacgattta agcgtcttgt tggtgttcag   60
cgcacgactt ttaaagagat gttagctgta ttaaaaacag cttatcaact taaacacgca   120
aaaggtggac gaaaacctaa attaagccta gaataccgca cttatgaaga aattgcggct   180
gattttggta ttcacgaaag caacttaatc cgtcggagcc aatgggttga agtaactctt   240
gttcaaagtg gtgttacgat ttcaagaact cctcttagtt ctgaggacac ggtaatgatt   300
gatgcgacgg aagtaaaaat caatcgccct aaaaaaagaa ttagcgaa                348

<210>   4478
<211>   116
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA, truncation FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903987 (3.E-56)

<400>   4478
Asn Tyr Glu Ala Ser Lys Gln Leu Thr Asp Thr Arg Phe Lys Arg Leu 
1               5                   10                  15      

Val Gly Val Gln Arg Thr Thr Phe Lys Glu Met Leu Ala Val Leu Lys 
            20                  25                  30          

Thr Ala Tyr Gln Leu Lys His Ala Lys Gly Gly Arg Lys Pro Lys Leu 
        35                  40                  45              

Ser Leu Glu Tyr Arg Thr Tyr Glu Glu Ile Ala Ala Asp Phe Gly Ile 
    50                  55                  60                  

His Glu Ser Asn Leu Ile Arg Arg Ser Gln Trp Val Glu Val Thr Leu 
65                  70                  75                  80  

Val Gln Ser Gly Val Thr Ile Ser Arg Thr Pro Leu Ser Ser Glu Asp 
                85                  90                  95      

Thr Val Met Ile Asp Ala Thr Glu Val Lys Ile Asn Arg Pro Lys Lys 
            100                 105                 110         

Arg Ile Ser Glu 
        115     

<210>   4479
<211>   387
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4479
atgaaggctc aagcgattgt cacaagtcaa gggagaattg tttctttgga tatcactgtg   60
aactattgtc atgatatgaa gttgttcaaa atgagttgca gaaatatcgg acaagctggt   120
aaaatcttgg ctgacagtgg ttatcaaggg ctcatgaaga tatgtcctca agcacaaact   180
tcacgtaaat ccagcaaact caagccacta acagctgaag ataaagccta taaccatgcg   240
ctatctaagg agagaagcaa ggttgagaac atctttgcca aagtaaaaac gtttaaaatg   300
ttttcaacaa cctatcgaaa tcatcgtaaa cgcttcggat tacgaatgaa tttgattgct   360
ggtattatca atcatgaact aggattc                                       387

<210>   4480
<211>   129
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfB FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903038 (2.E-67)

<400>   4480
Met Lys Ala Gln Ala Ile Val Thr Ser Gln Gly Arg Ile Val Ser Leu 
1               5                   10                  15      

Asp Ile Thr Val Asn Tyr Cys His Asp Met Lys Leu Phe Lys Met Ser 
            20                  25                  30          

Cys Arg Asn Ile Gly Gln Ala Gly Lys Ile Leu Ala Asp Ser Gly Tyr 
        35                  40                  45              

Gln Gly Leu Met Lys Ile Cys Pro Gln Ala Gln Thr Ser Arg Lys Ser 
    50                  55                  60                  

Ser Lys Leu Lys Pro Leu Thr Ala Glu Asp Lys Ala Tyr Asn His Ala 
65                  70                  75                  80  

Leu Ser Lys Glu Arg Ser Lys Val Glu Asn Ile Phe Ala Lys Val Lys 
                85                  90                  95      

Thr Phe Lys Met Phe Ser Thr Thr Tyr Arg Asn His Arg Lys Arg Phe 
            100                 105                 110         

Gly Leu Arg Met Asn Leu Ile Ala Gly Ile Ile Asn His Glu Leu Gly 
        115                 120                 125             

Phe 
    

<210>   4481
<211>   324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4481
gtgattttat ggagttttga ttttgcaaat gatcatgctc acgcattttt catggataat   60
gttgagtgga gtcatgcaga ttcttacttt cgtagctttg ttagtgacga tgttgaagaa   120
cgttacacag aaaatgtcta tctggatagc ctaagtgtca aacaaaaatt taagtttatt   180
ttcgacttcg gtgatgaatg gcgttttgaa tgccaagtgc tgagagaaat cgagacagag   240
gacgaagaag cttatctcgt acgttcggtt ggaacgtcgc cagaacaata tccagattat   300
gatggttttg actatgaaga atgg                                          324

<210>   4482
<211>   108
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903989 (8.E-63)

<400>   4482
Met Ile Leu Trp Ser Phe Asp Phe Ala Asn Asp His Ala His Ala Phe 
1               5                   10                  15      

Phe Met Asp Asn Val Glu Trp Ser His Ala Asp Ser Tyr Phe Arg Ser 
            20                  25                  30          

Phe Val Ser Asp Asp Val Glu Glu Arg Tyr Thr Glu Asn Val Tyr Leu 
        35                  40                  45              

Asp Ser Leu Ser Val Lys Gln Lys Phe Lys Phe Ile Phe Asp Phe Gly 
    50                  55                  60                  

Asp Glu Trp Arg Phe Glu Cys Gln Val Leu Arg Glu Ile Glu Thr Glu 
65                  70                  75                  80  

Asp Glu Glu Ala Tyr Leu Val Arg Ser Val Gly Thr Ser Pro Glu Gln 
                85                  90                  95      

Tyr Pro Asp Tyr Asp Gly Phe Asp Tyr Glu Glu Trp 
            100                 105             

<210>   4483
<211>   207
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4483
gtgaaacaga agaattatct ggtttcaaat gctacagtta gacaaactta tgataaaata   60
gcagaaagtg aatgtttcct aagagcaatt ggaggtatta tgctacactt aaaattagta   120
aaacaagaaa tagaagctga aaagccagca tctgtagaag cttggatcat ttccgtcaaa   180
tttaaaaaag gttgctaccg acatata                                       207

<210>   4484
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4484
Met Lys Gln Lys Asn Tyr Leu Val Ser Asn Ala Thr Val Arg Gln Thr 
1               5                   10                  15      

Tyr Asp Lys Ile Ala Glu Ser Glu Cys Phe Leu Arg Ala Ile Gly Gly 
            20                  25                  30          

Ile Met Leu His Leu Lys Leu Val Lys Gln Glu Ile Glu Ala Glu Lys 
        35                  40                  45              

Pro Ala Ser Val Glu Ala Trp Ile Ile Ser Val Lys Phe Lys Lys Gly 
    50                  55                  60                  

Cys Tyr Arg His Ile 
65                  

<210>   4485
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4485
ttgaaaccag ataattcttc tgtttcacgc gaaacaccct gcgccaagca aggtgttctt   60
gtttttatac tcaatgaaaa tcaaagagca aac                                93

<210>   4486
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4486
Met Lys Pro Asp Asn Ser Ser Val Ser Arg Glu Thr Pro Cys Ala Lys 
1               5                   10                  15      

Gln Gly Val Leu Val Phe Ile Leu Asn Glu Asn Gln Arg Ala Asn 
            20                  25                  30      

<210>   4487
<211>   1878
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4487
atggtaagat ttacaggact tagtctcaaa caaacgcaag ctattgaggt tttaaaaggt   60
cacatttctc taccagatgt ggaagtggct gtcactcagt ctgaccaagc atctatctct   120
atcgagggtg aggaaggtca ctatcaattg acctaccgca aacctcacca actttatcgt   180
gccttgtcct tgttggtaac agttctagca gaagctgata aagtagagat tgaggaacaa   240
gcagcttacg aagatttggc ttacatggtt gactgttctc gaaatgcggt gctgaatgtg   300
gcttctgcca agcagatgat tgagatattg gctctcatgg gctactcaac ctttgagctt   360
tacatggaag acacttacca gattgaaggg cagccttact ttggctattt ccgtggagct   420
tattcagcag aggagttgca ggaaatcgaa gcctatgccc aacagtttga cgtgaccttt   480
gtaccatgca tccagacctt ggcccacttg tcggcctttg tcaaatgggg tgtcaaggaa   540
gtgcaggagc tccgtgatgt agaggacatt cttctcattg gcgaagaaaa ggtttatgac   600
ttgattgatg gcatgtttgc cacgttgtct aaactgaaga ctcgcaaggt caatatcggg   660
atggacgaag cccacttggt tggtttggga cgctacctga ttctgaacgg tgttgtggat   720
cgtagtctcc tcatgtgcca acacttggag cgcgtgctgg atattgctga caaatatggt   780
ttccactgcc agatgtggag tgatatgttc ttcaaactca tgtcagcgga tggccagtac   840
gaccgtgatg tggaaattcc agaggaaact cgtgtctacc tagaccgtct caaagaccgt   900
gtgactctgg tttactggga ttattatcag gatagcgagg aaaaatacaa ccgtaatttc   960
cgcaatcatc acaagattag ccatgacctt gcatttgcag ggggagcttg gaagtggatt   1020
ggctttacac ctcacaacca ttttagccgt ctagtggcta tcgaggctaa taaagcctgc   1080
cgtgccaatc agattaaaga agtcatcgta acgggttggg gagacaatgg tggtgaaact   1140
gcccagttct ctatcctacc aagcttgcaa atctgggcag aactcagcta tcgcaatgac   1200
ctagatggtt tgtctgcgca cttcaagacc aatactggtc taacggttga ggattttatg   1260
cagattgacc ttgccaacct cttaccagac ctaccaggca atctcagcgg tatcaatccc   1320
aaccgctatg ttttttatca ggatattctt tgtccgattc ttgatcaaca catgacacct   1380
gaacaggaca aaccgcactt cgctcaggct gctgagacgc ttgctaacat taaagaaaaa   1440
gctggaaact atgcctatct ctttgaaact caggcccagt tgaatgctat tttaagtagc   1500
aaagtagatg tgggacgacg cattcgtcag gcctaccaag cggatgataa agaaagttta   1560
caacaaatcg ccagacaaga attaccagaa cttagaagcc aaattgaaga cttccatgcc   1620
ctctttagcc accaatggct gaaagaaaac aaggtctttg gtttggatac agttgacatc   1680
cgtatgggcg gactcttgca acgcatcaaa cgagcagaaa gccgtatcga ggtttatctg   1740
gctggtcagc ttgaccgcat cgacgagctg gaagttgaaa tcctaccatt tactgacttc   1800
tacgcagaca aggatttcgc agcaactaca gccaaccagt ggcataccat tgcgacagcg   1860
tcgacgattt atacgact                                                 1878


<210>   4488
<211>   626
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl hydrolase-related protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903990 (0.E+01)

<400>   4488
Met Val Arg Phe Thr Gly Leu Ser Leu Lys Gln Thr Gln Ala Ile Glu 
1               5                   10                  15      

Val Leu Lys Gly His Ile Ser Leu Pro Asp Val Glu Val Ala Val Thr 
            20                  25                  30          

Gln Ser Asp Gln Ala Ser Ile Ser Ile Glu Gly Glu Glu Gly His Tyr 
        35                  40                  45              

Gln Leu Thr Tyr Arg Lys Pro His Gln Leu Tyr Arg Ala Leu Ser Leu 
    50                  55                  60                  

Leu Val Thr Val Leu Ala Glu Ala Asp Lys Val Glu Ile Glu Glu Gln 
65                  70                  75                  80  

Ala Ala Tyr Glu Asp Leu Ala Tyr Met Val Asp Cys Ser Arg Asn Ala 
                85                  90                  95      

Val Leu Asn Val Ala Ser Ala Lys Gln Met Ile Glu Ile Leu Ala Leu 
            100                 105                 110         

Met Gly Tyr Ser Thr Phe Glu Leu Tyr Met Glu Asp Thr Tyr Gln Ile 
        115                 120                 125             

Glu Gly Gln Pro Tyr Phe Gly Tyr Phe Arg Gly Ala Tyr Ser Ala Glu 
    130                 135                 140                 

Glu Leu Gln Glu Ile Glu Ala Tyr Ala Gln Gln Phe Asp Val Thr Phe 
145                 150                 155                 160 

Val Pro Cys Ile Gln Thr Leu Ala His Leu Ser Ala Phe Val Lys Trp 
                165                 170                 175     

Gly Val Lys Glu Val Gln Glu Leu Arg Asp Val Glu Asp Ile Leu Leu 
            180                 185                 190         

Ile Gly Glu Glu Lys Val Tyr Asp Leu Ile Asp Gly Met Phe Ala Thr 
        195                 200                 205             

Leu Ser Lys Leu Lys Thr Arg Lys Val Asn Ile Gly Met Asp Glu Ala 
    210                 215                 220                 

His Leu Val Gly Leu Gly Arg Tyr Leu Ile Leu Asn Gly Val Val Asp 
225                 230                 235                 240 

Arg Ser Leu Leu Met Cys Gln His Leu Glu Arg Val Leu Asp Ile Ala 
                245                 250                 255     

Asp Lys Tyr Gly Phe His Cys Gln Met Trp Ser Asp Met Phe Phe Lys 
            260                 265                 270         

Leu Met Ser Ala Asp Gly Gln Tyr Asp Arg Asp Val Glu Ile Pro Glu 
        275                 280                 285             

Glu Thr Arg Val Tyr Leu Asp Arg Leu Lys Asp Arg Val Thr Leu Val 
    290                 295                 300                 

Tyr Trp Asp Tyr Tyr Gln Asp Ser Glu Glu Lys Tyr Asn Arg Asn Phe 
305                 310                 315                 320 

Arg Asn His His Lys Ile Ser His Asp Leu Ala Phe Ala Gly Gly Ala 
                325                 330                 335     

Trp Lys Trp Ile Gly Phe Thr Pro His Asn His Phe Ser Arg Leu Val 
            340                 345                 350         

Ala Ile Glu Ala Asn Lys Ala Cys Arg Ala Asn Gln Ile Lys Glu Val 
        355                 360                 365             

Ile Val Thr Gly Trp Gly Asp Asn Gly Gly Glu Thr Ala Gln Phe Ser 
    370                 375                 380                 

Ile Leu Pro Ser Leu Gln Ile Trp Ala Glu Leu Ser Tyr Arg Asn Asp 
385                 390                 395                 400 

Leu Asp Gly Leu Ser Ala His Phe Lys Thr Asn Thr Gly Leu Thr Val 
                405                 410                 415     

Glu Asp Phe Met Gln Ile Asp Leu Ala Asn Leu Leu Pro Asp Leu Pro 
            420                 425                 430         

Gly Asn Leu Ser Gly Ile Asn Pro Asn Arg Tyr Val Phe Tyr Gln Asp 
        435                 440                 445             

Ile Leu Cys Pro Ile Leu Asp Gln His Met Thr Pro Glu Gln Asp Lys 
    450                 455                 460                 

Pro His Phe Ala Gln Ala Ala Glu Thr Leu Ala Asn Ile Lys Glu Lys 
465                 470                 475                 480 

Ala Gly Asn Tyr Ala Tyr Leu Phe Glu Thr Gln Ala Gln Leu Asn Ala 
                485                 490                 495     

Ile Leu Ser Ser Lys Val Asp Val Gly Arg Arg Ile Arg Gln Ala Tyr 
            500                 505                 510         

Gln Ala Asp Asp Lys Glu Ser Leu Gln Gln Ile Ala Arg Gln Glu Leu 
        515                 520                 525             

Pro Glu Leu Arg Ser Gln Ile Glu Asp Phe His Ala Leu Phe Ser His 
    530                 535                 540                 

Gln Trp Leu Lys Glu Asn Lys Val Phe Gly Leu Asp Thr Val Asp Ile 
545                 550                 555                 560 

Arg Met Gly Gly Leu Leu Gln Arg Ile Lys Arg Ala Glu Ser Arg Ile 
                565                 570                 575     

Glu Val Tyr Leu Ala Gly Gln Leu Asp Arg Ile Asp Glu Leu Glu Val 
            580                 585                 590         

Glu Ile Leu Pro Phe Thr Asp Phe Tyr Ala Asp Lys Asp Phe Ala Ala 
        595                 600                 605             

Thr Thr Ala Asn Gln Trp His Thr Ile Ala Thr Ala Ser Thr Ile Tyr 
    610                 615                 620                 

Thr Thr 
625     

<210>   4489
<211>   867
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4489
atgaccattg caacgattga tatcggaggg actgggatta agtttgccag tctgactcct   60
gatgggaaaa tactggataa gacaagtatt tcaacgcctg aaaacttgga ggatttacta   120
gcgtggctag atcaacgctt gtcagaacag gattacagtg ggattgctat gagcgttcca   180
ggtgcagtca atcaagagac aggtgtgatt gatggcttca gtgcggtgcc ctacatccat   240
ggcttttctt ggtatgaggc gcttagctct tatcagctac ctgtccattt agaaaatgat   300
gccaactgcg ttggactcag tgaactacta gctcatccag agcttgaaaa tgcagcctgt   360
gtcgtgattg ggacagggat tggcggagcc atgattatca atggtagact tcatcgaggt   420
cgccacggtc tgggtggaga atttggctac atgacaaccc ttgcccctgc tgaaaaactt   480
aataactggt cgcaactagc atcaactggg aatatggtac gatacgtgat tgaaaaatct   540
ggtcatactg attgggacgg tcgcaagatt taccaagagg ccgcagctgg taatatcctt   600
tgtcaagaag ccattgagcg catgaaccgc aatctggcgc aaggcttgct caatatccag   660
tatctgatcg atccaggtgt catcagtctg ggtggctcta tcagtcaaaa tccagatttt   720
atccaaggtg tcaagaaggc tgttgaagac tttgtcgatg cctacgaaga atacacggtc   780
gcaccagtta tccaggcctg cacctatcac gcagatgcca atctctacgg tgctcttgtc   840
aactggctac aggaggaaaa gcaatgg                                       867

<210>   4490
<211>   289
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ROK family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903991 (e-167)

<400>   4490
Met Thr Ile Ala Thr Ile Asp Ile Gly Gly Thr Gly Ile Lys Phe Ala 
1               5                   10                  15      

Ser Leu Thr Pro Asp Gly Lys Ile Leu Asp Lys Thr Ser Ile Ser Thr 
            20                  25                  30          

Pro Glu Asn Leu Glu Asp Leu Leu Ala Trp Leu Asp Gln Arg Leu Ser 
        35                  40                  45              

Glu Gln Asp Tyr Ser Gly Ile Ala Met Ser Val Pro Gly Ala Val Asn 
    50                  55                  60                  

Gln Glu Thr Gly Val Ile Asp Gly Phe Ser Ala Val Pro Tyr Ile His 
65                  70                  75                  80  

Gly Phe Ser Trp Tyr Glu Ala Leu Ser Ser Tyr Gln Leu Pro Val His 
                85                  90                  95      

Leu Glu Asn Asp Ala Asn Cys Val Gly Leu Ser Glu Leu Leu Ala His 
            100                 105                 110         

Pro Glu Leu Glu Asn Ala Ala Cys Val Val Ile Gly Thr Gly Ile Gly 
        115                 120                 125             

Gly Ala Met Ile Ile Asn Gly Arg Leu His Arg Gly Arg His Gly Leu 
    130                 135                 140                 

Gly Gly Glu Phe Gly Tyr Met Thr Thr Leu Ala Pro Ala Glu Lys Leu 
145                 150                 155                 160 

Asn Asn Trp Ser Gln Leu Ala Ser Thr Gly Asn Met Val Arg Tyr Val 
                165                 170                 175     

Ile Glu Lys Ser Gly His Thr Asp Trp Asp Gly Arg Lys Ile Tyr Gln 
            180                 185                 190         

Glu Ala Ala Ala Gly Asn Ile Leu Cys Gln Glu Ala Ile Glu Arg Met 
        195                 200                 205             


Asn Arg Asn Leu Ala Gln Gly Leu Leu Asn Ile Gln Tyr Leu Ile Asp 
    210                 215                 220                 

Pro Gly Val Ile Ser Leu Gly Gly Ser Ile Ser Gln Asn Pro Asp Phe 
225                 230                 235                 240 

Ile Gln Gly Val Lys Lys Ala Val Glu Asp Phe Val Asp Ala Tyr Glu 
                245                 250                 255     

Glu Tyr Thr Val Ala Pro Val Ile Gln Ala Cys Thr Tyr His Ala Asp 
            260                 265                 270         

Ala Asn Leu Tyr Gly Ala Leu Val Asn Trp Leu Gln Glu Glu Lys Gln 
        275                 280                 285             

Trp 
    

<210>   4491
<211>   2658
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4491
atgaggtttt acttcatgga aaatgttgtt gtacatatta tctcacatag tcactgggat   60
cgtgagtggt acttgccttt tgaaagccat cgtatgcagt tggtggaatt gtttgacaat   120
ctctttgatc tctttgaaaa tgaccctgag ttcaagagtt tccacttgga tggacaaact   180
attgtccttg atgactactt acaaattcgc cctgaaaatc gcgacaaggt ccaacgctac   240
attgacgagg gcaaacttaa aattggtccc ttttacatct tgcaggatga ctacttgatc   300
tccagtgaag ccaatgtccg caataccttg attggtcaac aagaagctgc caaatggggt   360
aaatcaaccc agattggcta ctttccagat acctttggaa atatgggaca agcgcctcaa   420
attcttcaaa aatcaggcat tcacgtggcg gcctttggtc gtggtgtgaa gccgattgga   480
tttgacaacc aagtccttga agatgagcag tttacgtctc agttttcaga aatgtactgg   540
cagggtgtgg atggtagtcg tgttttaggt attctctttg ccaactggta cagtaacggg   600
aatgaaattc cagttgacaa agatgaggcc ttgaccttct ggaaacaaaa attgtcagat   660
gtgcgtgcct acgcttcgac caaccaatgg ttgatgatga acggctgtga ccaccagcct   720
gtacagaaaa atctgagcga agccattcgt gtggcaaatg aactcttccc ggatgtaatc   780
tttgttcata gttcttttga tgaatatgtt caagctgtag aaggtgcgct tcctgaacac   840
ttatcaactg ttacaggcga gttgaccagt caggaaacag atggctggta cacacttgcc   900
aacacttctt catcccgcat ttacctaaaa caagccttcc aagaaaatag caacctccta   960
gagcaagtgg tagaaccctt gactattatc actggtggac acaaccacaa ggaccagttg   1020
acctatgctt ggaaaacact tttgcagaat gcgccacatg atagtatctg tggctgtagc   1080
gtggacgaag ttcaccgcga gatggaaacg cgttttgcca aggtcaacca agtaggaaac   1140
tttgttaaaa gtaacttgct caacgagtgg aagggtaaaa ttgctacgga taaggctcaa   1200
agtgactatc tctttactgt cattaacaca ggcttgcatg ataaggtcga tactgtcagc   1260
acagtgattg atgtggcgac ttgtgatttc aaggaattgc acccaacaga aggctacaaa   1320
aagatggctg ctcttatctt gccaagttac cgtgtggagg acttggatgg tcgtcctgta   1380
gaggctacaa tcgaagacct cggagctaat tttgagtata atttaccaaa agacaagttc   1440
cgccaagctc gtattgctcg tcaagtgcgc gtgaccattc cagttcacct agcgccgctt   1500
tcttggacaa ccttccaatt gctggaagga aaacaagaac accgtgaggg tatttaccaa   1560
aacggagtga ttgatacacc attcgtaacg gtgagtgtgg atgacaacat cacagtctat   1620
gacaagacaa ctcacgaagc ctatgaagac tttatccgct ttgaagaccg tggggacatc   1680
ggaaacgagt atatctattt ccaaccaaaa ggaacagagc caatctttgc agagcttaag   1740
ggccacgagg tcttggaaaa cacagcttgc tatgctaaaa tcttgctcaa acatgaattg   1800
accgtgcctg tcagtgcgga tgaaaagcta gaagaagagc aacaaggtat catcgagttt   1860
atgaagcgtg aggctggacg gtcagaagaa ttgacaaaca ttcctctgga aactgagttg   1920
actgtcttcg ttgacaatcc acaaatccgc ttcaagactc gctttactaa cactgccaag   1980
gatcaccgta tccgtctctt ggtcaagact cataacacgc gtccaagcaa tgattctgaa   2040
agtatctatg aggtggtgac acgaccaaac aaaccagctg cttcatggga aaaccctgaa   2100
aatcctcaac accaacaagc ttttgtcagt ctgtatgacg atgaaaaagg ggtgactgta   2160
tccaacaagg gattgaatga atacgaaatc cttggggata acaccattgc cgtgaccatt   2220
ttgcgtgcat caggtgagct aggtgactgg ggctacttcc caacgccaga agcacaatgc   2280
ttgcgggagt ttgaagtcga gtttgcactt gaatgccacc aagcccaaga acgcttctca   2340
gcctatcgtc gtgccaaagc cttgcagaca ccgtttacca gccttcagct tgctagacag   2400
gaaggaagcg tggttgcgac tggtagcctc ttgagccatt ctgttctcag cataccgcaa   2460
gtttgtccaa cagcctttaa ggtagctgaa aatgaagaag gctatgtgct tcgttactac   2520
aatatgtgta gtgaaaatgt acgtgtgcca gaaagtcaac atctcttcct tgacctactt   2580
gaacgaccat acccagttca ttcaggacta ttggctccac aagagattcg tacagaattc   2640
atcaaaaaag aagaaatt                                                 2658

<210>   4492
<211>   886
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15903992 (0.E+01)

<400>   4492
Met Arg Phe Tyr Phe Met Glu Asn Val Val Val His Ile Ile Ser His 
1               5                   10                  15      

Ser His Trp Asp Arg Glu Trp Tyr Leu Pro Phe Glu Ser His Arg Met 
            20                  25                  30          

Gln Leu Val Glu Leu Phe Asp Asn Leu Phe Asp Leu Phe Glu Asn Asp 
        35                  40                  45              

Pro Glu Phe Lys Ser Phe His Leu Asp Gly Gln Thr Ile Val Leu Asp 
    50                  55                  60                  

Asp Tyr Leu Gln Ile Arg Pro Glu Asn Arg Asp Lys Val Gln Arg Tyr 
65                  70                  75                  80  

Ile Asp Glu Gly Lys Leu Lys Ile Gly Pro Phe Tyr Ile Leu Gln Asp 
                85                  90                  95      

Asp Tyr Leu Ile Ser Ser Glu Ala Asn Val Arg Asn Thr Leu Ile Gly 
            100                 105                 110         

Gln Gln Glu Ala Ala Lys Trp Gly Lys Ser Thr Gln Ile Gly Tyr Phe 
        115                 120                 125             

Pro Asp Thr Phe Gly Asn Met Gly Gln Ala Pro Gln Ile Leu Gln Lys 
    130                 135                 140                 

Ser Gly Ile His Val Ala Ala Phe Gly Arg Gly Val Lys Pro Ile Gly 
145                 150                 155                 160 

Phe Asp Asn Gln Val Leu Glu Asp Glu Gln Phe Thr Ser Gln Phe Ser 
                165                 170                 175     

Glu Met Tyr Trp Gln Gly Val Asp Gly Ser Arg Val Leu Gly Ile Leu 
            180                 185                 190         

Phe Ala Asn Trp Tyr Ser Asn Gly Asn Glu Ile Pro Val Asp Lys Asp 
        195                 200                 205             

Glu Ala Leu Thr Phe Trp Lys Gln Lys Leu Ser Asp Val Arg Ala Tyr 
    210                 215                 220                 

Ala Ser Thr Asn Gln Trp Leu Met Met Asn Gly Cys Asp His Gln Pro 
225                 230                 235                 240 

Val Gln Lys Asn Leu Ser Glu Ala Ile Arg Val Ala Asn Glu Leu Phe 
                245                 250                 255     

Pro Asp Val Ile Phe Val His Ser Ser Phe Asp Glu Tyr Val Gln Ala 
            260                 265                 270         

Val Glu Gly Ala Leu Pro Glu His Leu Ser Thr Val Thr Gly Glu Leu 
        275                 280                 285             

Thr Ser Gln Glu Thr Asp Gly Trp Tyr Thr Leu Ala Asn Thr Ser Ser 
    290                 295                 300                 

Ser Arg Ile Tyr Leu Lys Gln Ala Phe Gln Glu Asn Ser Asn Leu Leu 
305                 310                 315                 320 

Glu Gln Val Val Glu Pro Leu Thr Ile Ile Thr Gly Gly His Asn His 
                325                 330                 335     

Lys Asp Gln Leu Thr Tyr Ala Trp Lys Thr Leu Leu Gln Asn Ala Pro 
            340                 345                 350         

His Asp Ser Ile Cys Gly Cys Ser Val Asp Glu Val His Arg Glu Met 
        355                 360                 365             

Glu Thr Arg Phe Ala Lys Val Asn Gln Val Gly Asn Phe Val Lys Ser 
    370                 375                 380                 

Asn Leu Leu Asn Glu Trp Lys Gly Lys Ile Ala Thr Asp Lys Ala Gln 
385                 390                 395                 400 

Ser Asp Tyr Leu Phe Thr Val Ile Asn Thr Gly Leu His Asp Lys Val 
                405                 410                 415     

Asp Thr Val Ser Thr Val Ile Asp Val Ala Thr Cys Asp Phe Lys Glu 
            420                 425                 430         

Leu His Pro Thr Glu Gly Tyr Lys Lys Met Ala Ala Leu Ile Leu Pro 
        435                 440                 445             

Ser Tyr Arg Val Glu Asp Leu Asp Gly Arg Pro Val Glu Ala Thr Ile 
    450                 455                 460                 

Glu Asp Leu Gly Ala Asn Phe Glu Tyr Asn Leu Pro Lys Asp Lys Phe 
465                 470                 475                 480 

Arg Gln Ala Arg Ile Ala Arg Gln Val Arg Val Thr Ile Pro Val His 
                485                 490                 495     

Leu Ala Pro Leu Ser Trp Thr Thr Phe Gln Leu Leu Glu Gly Lys Gln 
            500                 505                 510         

Glu His Arg Glu Gly Ile Tyr Gln Asn Gly Val Ile Asp Thr Pro Phe 
        515                 520                 525             

Val Thr Val Ser Val Asp Asp Asn Ile Thr Val Tyr Asp Lys Thr Thr 
    530                 535                 540                 

His Glu Ala Tyr Glu Asp Phe Ile Arg Phe Glu Asp Arg Gly Asp Ile 
545                 550                 555                 560 

Gly Asn Glu Tyr Ile Tyr Phe Gln Pro Lys Gly Thr Glu Pro Ile Phe 
                565                 570                 575     

Ala Glu Leu Lys Gly His Glu Val Leu Glu Asn Thr Ala Cys Tyr Ala 
            580                 585                 590         

Lys Ile Leu Leu Lys His Glu Leu Thr Val Pro Val Ser Ala Asp Glu 
        595                 600                 605             

Lys Leu Glu Glu Glu Gln Gln Gly Ile Ile Glu Phe Met Lys Arg Glu 
    610                 615                 620                 

Ala Gly Arg Ser Glu Glu Leu Thr Asn Ile Pro Leu Glu Thr Glu Leu 
625                 630                 635                 640 

Thr Val Phe Val Asp Asn Pro Gln Ile Arg Phe Lys Thr Arg Phe Thr 
                645                 650                 655     

Asn Thr Ala Lys Asp His Arg Ile Arg Leu Leu Val Lys Thr His Asn 
            660                 665                 670         

Thr Arg Pro Ser Asn Asp Ser Glu Ser Ile Tyr Glu Val Val Thr Arg 
        675                 680                 685             

Pro Asn Lys Pro Ala Ala Ser Trp Glu Asn Pro Glu Asn Pro Gln His 
    690                 695                 700                 

Gln Gln Ala Phe Val Ser Leu Tyr Asp Asp Glu Lys Gly Val Thr Val 
705                 710                 715                 720 

Ser Asn Lys Gly Leu Asn Glu Tyr Glu Ile Leu Gly Asp Asn Thr Ile 
                725                 730                 735     

Ala Val Thr Ile Leu Arg Ala Ser Gly Glu Leu Gly Asp Trp Gly Tyr 
            740                 745                 750         

Phe Pro Thr Pro Glu Ala Gln Cys Leu Arg Glu Phe Glu Val Glu Phe 
        755                 760                 765             

Ala Leu Glu Cys His Gln Ala Gln Glu Arg Phe Ser Ala Tyr Arg Arg 
    770                 775                 780                 

Ala Lys Ala Leu Gln Thr Pro Phe Thr Ser Leu Gln Leu Ala Arg Gln 
785                 790                 795                 800 

Glu Gly Ser Val Val Ala Thr Gly Ser Leu Leu Ser His Ser Val Leu 
                805                 810                 815     

Ser Ile Pro Gln Val Cys Pro Thr Ala Phe Lys Val Ala Glu Asn Glu 
            820                 825                 830         

Glu Gly Tyr Val Leu Arg Tyr Tyr Asn Met Cys Ser Glu Asn Val Arg 
        835                 840                 845             

Val Pro Glu Ser Gln His Leu Phe Leu Asp Leu Leu Glu Arg Pro Tyr 
    850                 855                 860                 

Pro Val His Ser Gly Leu Leu Ala Pro Gln Glu Ile Arg Thr Glu Phe 
865                 870                 875                 880 

Ile Lys Lys Glu Glu Ile 
                885     

<210>   4493
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4493
atgtattttc tgtctcaaaa gctatatact gaacatgaaa cttgtttgaa agaggtaaaa   60
tttaaaatgg tttattcgaa agaaattgtc agagagtggc tagatgaagt agcagagcgg   120
gctaaggact atccagagtg ggtggatgtt ttcgagcgtt gctacaccga taccttggac   180
aatacggttg aaatcttaga agatggttca acttttgtct tgactgggga tattcctgcc   240
atgtggcttc gagattcgac agcccaactc agaccctacc ttcatgtagc taaaagagat   300
gccctcctgc gtcagaccat tgcaggtttg gtcaaacgtc agatgacctt ggtactcaag   360
gatccctatg ctaactcctt caacattgag gagaactgga aagggcacca cgagactgac   420
cacacagacc ttaacggctg gatctgggag cgcaagtatg aggtggattc gctttgctat   480
cctttgcagt tggcttatct cctctggaaa gagactggcg agactagtca gtttgatgag   540
atttttgtcg cagcgactaa ggaaattctc catctgtgga cggtggaaca agaccacaag   600
aactctcctt atcgttttgt ccgagatacg gaccgtaagg aagacacctt ggtaaatgat   660
ggctttggac ctgactttgc agtgacaggt atgacttggt cagcttttcg tccgagtgat   720
gactgttgcc agtatagtta cttgattccg tcaaatatgt ttgctgtagt agtcttgggt   780
tatgtgcaag aaatcttcgc agcattaaac ctagctgata gccagagtgt tattgctgat   840
gccaagcgtc ttcaggatga aatccaagaa ggaatcaaaa actacgctta caccaccaac   900
agcaagggcg aaaagattta cgcttttgaa gtggatggcc taggaaatgc cagcatcatg   960
gatgatccaa atgtaccaag tctactagct gcgccctatc tgggctactg ttcggtcgat   1020
gatgaagtgt atcaagctac tcgtcgtacc attttgagct ctgaaaatcc atacttctac   1080
caaggagaat acgcaagcgg tctcggcagt tctcatacct tctatcgcta tatctggcca   1140
atcgcccttt ctatccaagg cttgacaaca agagataagg cagagaaaaa attcttgctg   1200
gatcagctgg ttgcctgcga tggtggtaca ggtgtcatgc acgaaagctt tcatgtagat   1260
gatccgaccc tctactctcg tgaatggttc tcctgggcta acatgatgtt ctgtgagttg   1320
gtcttggatt acttggatat tcgc                                          1344

<210>   4494
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903993 (0.E+01)

<400>   4494
Met Tyr Phe Leu Ser Gln Lys Leu Tyr Thr Glu His Glu Thr Cys Leu 
1               5                   10                  15      

Lys Glu Val Lys Phe Lys Met Val Tyr Ser Lys Glu Ile Val Arg Glu 
            20                  25                  30          

Trp Leu Asp Glu Val Ala Glu Arg Ala Lys Asp Tyr Pro Glu Trp Val 
        35                  40                  45              

Asp Val Phe Glu Arg Cys Tyr Thr Asp Thr Leu Asp Asn Thr Val Glu 
    50                  55                  60                  

Ile Leu Glu Asp Gly Ser Thr Phe Val Leu Thr Gly Asp Ile Pro Ala 
65                  70                  75                  80  

Met Trp Leu Arg Asp Ser Thr Ala Gln Leu Arg Pro Tyr Leu His Val 
                85                  90                  95      

Ala Lys Arg Asp Ala Leu Leu Arg Gln Thr Ile Ala Gly Leu Val Lys 
            100                 105                 110         

Arg Gln Met Thr Leu Val Leu Lys Asp Pro Tyr Ala Asn Ser Phe Asn 
        115                 120                 125             

Ile Glu Glu Asn Trp Lys Gly His His Glu Thr Asp His Thr Asp Leu 
    130                 135                 140                 

Asn Gly Trp Ile Trp Glu Arg Lys Tyr Glu Val Asp Ser Leu Cys Tyr 
145                 150                 155                 160 

Pro Leu Gln Leu Ala Tyr Leu Leu Trp Lys Glu Thr Gly Glu Thr Ser 
                165                 170                 175     

Gln Phe Asp Glu Ile Phe Val Ala Ala Thr Lys Glu Ile Leu His Leu 
            180                 185                 190         

Trp Thr Val Glu Gln Asp His Lys Asn Ser Pro Tyr Arg Phe Val Arg 
        195                 200                 205             

Asp Thr Asp Arg Lys Glu Asp Thr Leu Val Asn Asp Gly Phe Gly Pro 
    210                 215                 220                 

Asp Phe Ala Val Thr Gly Met Thr Trp Ser Ala Phe Arg Pro Ser Asp 
225                 230                 235                 240 

Asp Cys Cys Gln Tyr Ser Tyr Leu Ile Pro Ser Asn Met Phe Ala Val 
                245                 250                 255     

Val Val Leu Gly Tyr Val Gln Glu Ile Phe Ala Ala Leu Asn Leu Ala 
            260                 265                 270         

Asp Ser Gln Ser Val Ile Ala Asp Ala Lys Arg Leu Gln Asp Glu Ile 
        275                 280                 285             

Gln Glu Gly Ile Lys Asn Tyr Ala Tyr Thr Thr Asn Ser Lys Gly Glu 
    290                 295                 300                 

Lys Ile Tyr Ala Phe Glu Val Asp Gly Leu Gly Asn Ala Ser Ile Met 
305                 310                 315                 320 

Asp Asp Pro Asn Val Pro Ser Leu Leu Ala Ala Pro Tyr Leu Gly Tyr 
                325                 330                 335     


Cys Ser Val Asp Asp Glu Val Tyr Gln Ala Thr Arg Arg Thr Ile Leu 
            340                 345                 350         

Ser Ser Glu Asn Pro Tyr Phe Tyr Gln Gly Glu Tyr Ala Ser Gly Leu 
        355                 360                 365             

Gly Ser Ser His Thr Phe Tyr Arg Tyr Ile Trp Pro Ile Ala Leu Ser 
    370                 375                 380                 

Ile Gln Gly Leu Thr Thr Arg Asp Lys Ala Glu Lys Lys Phe Leu Leu 
385                 390                 395                 400 

Asp Gln Leu Val Ala Cys Asp Gly Gly Thr Gly Val Met His Glu Ser 
                405                 410                 415     

Phe His Val Asp Asp Pro Thr Leu Tyr Ser Arg Glu Trp Phe Ser Trp 
            420                 425                 430         

Ala Asn Met Met Phe Cys Glu Leu Val Leu Asp Tyr Leu Asp Ile Arg 
        435                 440                 445             


<210>   4495
<211>   2082
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4495
atgaaaccac tacttgaaac catcgatacc cgctttggaa ctaccaacaa gcatgccttt   60
tctcggggaa ataccctgcc atacacaggc gtgccttttg ggatgaatta ctttgtgccc   120
cagaccagtg accaggatgg atcttggttt tttgatccac atctgcctat ctttcagggg   180
attcgattaa ctcaccagcc cagtccttgg attggggact actcttggct ccttctgaca   240
cctgtcacca gtcaactggg gggagacagc ctctttcacc gccagtcttc ttatgatata   300
gataaagctt gcttccagcc tcactatttg aagctctttt ctctgcgtta tcagattgaa   360
acccagctca caccgacttg ctatggtgct tctattcgtt tgaatcaaaa gcaaggcaaa   420
gccctctccc tctatcttca cgcagcagat gaactgacag tagagcaagt agataagcgg   480
actcttgccc tgcgacaaga aggtaaaact gaaactaaca aaaattcgct aacgatgttc   540
actgccctgc aaatgaacac ggatattctt gctatcagcc aagaagctgg agactggcga   600
attgacttag caagtagtca aaccgagatg caactagcca cttctttcat ctctccttct   660
caagctctaa tcaatctacc tcaagaagat tttgatagct gtaaatcaag tgcccaagtg   720
gattgggaaa atctcctcca tcgttttgac attatagaga caggagaggc tgaccgaacc   780
ttctttgacc actgcctcta cagactcttc ctcttcccac agacttttta tgagattaat   840
gaatcagggc aagccatcca catggatctg gctactggta ctgtcaagcc tggtgtcctc   900
tttagcaaca atggtttctg ggataccttc cgcaccacct tccccctctt tgcccttatc   960
ataccggagc actatcaacg ctttttagaa ggtttcctca atagctaccg cgatactggt   1020
ttccttccaa aatggctggc tccagatgaa cggggtatga tgccaggtac acttttagac   1080
ggtattatcg cagatagcgc ctgcaaggac atgacccccg acctagaagg agaactcttc   1140
caagccatgc tcgaaacagc cagcaaagcc gaccctctcg gcatcaatgg ccgccacgga   1200
ctagcccaat accaagaact aggttacctc tctaccgacc accacgaaag tgttagccat   1260
actctagact atgcctatag tgacttttgt atcgccagct gtgccaaaaa actagagaac   1320
atagaaatcg ctgaaaccta caaggctgct tcacaaaatt accgccagct atttgacgct   1380
gagacaggtt acatgcgagc acgagacaat caaggaaact ttcaccctga cttctctcct   1440
tatagttggg ggcgagacta cgctgaatgc tctgccattc aagctacttt aggcgttctc   1500
cacgacatcc ctggcttaat ccaactgatg ggtggaaaag aaacctttag caactatctt   1560
ttgaaagcct gtcaagatgc tcccctcttt gaaacaacag gctatggtta cgaaattcac   1620
gaaatgagcg agatggctac tgctcctttt ggacaaatag ccatttccaa ccagcctagt   1680
ttccacattc cttatctctt ccgttacagc gattaccctg actacactgc ccttcttatc   1740
aagacgctcc gtcagaaagc ttttcaccca agttgggaag cctatcctgg agatgaagac   1800
aatggtagtc tctctgcttg gtacatctgg tcagctctcg gattttatcc aacctgtcca   1860
ggaaaaccaa gctatgacct cggaatccct ctctttgacc atctacgagt ctacctcgct   1920
aaagaagata aatggctgga tatccatact aaacaaaacc acaaccattt taactttgtc   1980
aaagaatgcc gactggacaa aacactcgta tcaactattc aacaccaaga cctcttaaaa   2040
gctgaacaac taactttcac cctcagctgg ttaccaagtc ac                      2082

<210>   4496
<211>   694
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   antigen, cell wall surface anchor family
<223>   Cellular location: cytoplasm
<223>   Feature of note: antigen
<223>   Similar to strain R6 sequence 15903994 (0.E+01)

<400>   4496
Met Lys Pro Leu Leu Glu Thr Ile Asp Thr Arg Phe Gly Thr Thr Asn 
1               5                   10                  15      

Lys His Ala Phe Ser Arg Gly Asn Thr Leu Pro Tyr Thr Gly Val Pro 
            20                  25                  30          

Phe Gly Met Asn Tyr Phe Val Pro Gln Thr Ser Asp Gln Asp Gly Ser 
        35                  40                  45              

Trp Phe Phe Asp Pro His Leu Pro Ile Phe Gln Gly Ile Arg Leu Thr 
    50                  55                  60                  

His Gln Pro Ser Pro Trp Ile Gly Asp Tyr Ser Trp Leu Leu Leu Thr 
65                  70                  75                  80  

Pro Val Thr Ser Gln Leu Gly Gly Asp Ser Leu Phe His Arg Gln Ser 
                85                  90                  95      

Ser Tyr Asp Ile Asp Lys Ala Cys Phe Gln Pro His Tyr Leu Lys Leu 
            100                 105                 110         

Phe Ser Leu Arg Tyr Gln Ile Glu Thr Gln Leu Thr Pro Thr Cys Tyr 
        115                 120                 125             

Gly Ala Ser Ile Arg Leu Asn Gln Lys Gln Gly Lys Ala Leu Ser Leu 
    130                 135                 140                 

Tyr Leu His Ala Ala Asp Glu Leu Thr Val Glu Gln Val Asp Lys Arg 
145                 150                 155                 160 

Thr Leu Ala Leu Arg Gln Glu Gly Lys Thr Glu Thr Asn Lys Asn Ser 
                165                 170                 175     

Leu Thr Met Phe Thr Ala Leu Gln Met Asn Thr Asp Ile Leu Ala Ile 
            180                 185                 190         

Ser Gln Glu Ala Gly Asp Trp Arg Ile Asp Leu Ala Ser Ser Gln Thr 
        195                 200                 205             

Glu Met Gln Leu Ala Thr Ser Phe Ile Ser Pro Ser Gln Ala Leu Ile 
    210                 215                 220                 

Asn Leu Pro Gln Glu Asp Phe Asp Ser Cys Lys Ser Ser Ala Gln Val 
225                 230                 235                 240 

Asp Trp Glu Asn Leu Leu His Arg Phe Asp Ile Ile Glu Thr Gly Glu 
                245                 250                 255     

Ala Asp Arg Thr Phe Phe Asp His Cys Leu Tyr Arg Leu Phe Leu Phe 
            260                 265                 270         

Pro Gln Thr Phe Tyr Glu Ile Asn Glu Ser Gly Gln Ala Ile His Met 
        275                 280                 285             

Asp Leu Ala Thr Gly Thr Val Lys Pro Gly Val Leu Phe Ser Asn Asn 
    290                 295                 300                 

Gly Phe Trp Asp Thr Phe Arg Thr Thr Phe Pro Leu Phe Ala Leu Ile 
305                 310                 315                 320 

Ile Pro Glu His Tyr Gln Arg Phe Leu Glu Gly Phe Leu Asn Ser Tyr 
                325                 330                 335     

Arg Asp Thr Gly Phe Leu Pro Lys Trp Leu Ala Pro Asp Glu Arg Gly 
            340                 345                 350         

Met Met Pro Gly Thr Leu Leu Asp Gly Ile Ile Ala Asp Ser Ala Cys 
        355                 360                 365             

Lys Asp Met Thr Pro Asp Leu Glu Gly Glu Leu Phe Gln Ala Met Leu 
    370                 375                 380                 

Glu Thr Ala Ser Lys Ala Asp Pro Leu Gly Ile Asn Gly Arg His Gly 
385                 390                 395                 400 

Leu Ala Gln Tyr Gln Glu Leu Gly Tyr Leu Ser Thr Asp His His Glu 
                405                 410                 415     

Ser Val Ser His Thr Leu Asp Tyr Ala Tyr Ser Asp Phe Cys Ile Ala 
            420                 425                 430         

Ser Cys Ala Lys Lys Leu Glu Asn Ile Glu Ile Ala Glu Thr Tyr Lys 
        435                 440                 445             

Ala Ala Ser Gln Asn Tyr Arg Gln Leu Phe Asp Ala Glu Thr Gly Tyr 
    450                 455                 460                 

Met Arg Ala Arg Asp Asn Gln Gly Asn Phe His Pro Asp Phe Ser Pro 
465                 470                 475                 480 

Tyr Ser Trp Gly Arg Asp Tyr Ala Glu Cys Ser Ala Ile Gln Ala Thr 
                485                 490                 495     

Leu Gly Val Leu His Asp Ile Pro Gly Leu Ile Gln Leu Met Gly Gly 
            500                 505                 510         

Lys Glu Thr Phe Ser Asn Tyr Leu Leu Lys Ala Cys Gln Asp Ala Pro 
        515                 520                 525             

Leu Phe Glu Thr Thr Gly Tyr Gly Tyr Glu Ile His Glu Met Ser Glu 
    530                 535                 540                 

Met Ala Thr Ala Pro Phe Gly Gln Ile Ala Ile Ser Asn Gln Pro Ser 
545                 550                 555                 560 

Phe His Ile Pro Tyr Leu Phe Arg Tyr Ser Asp Tyr Pro Asp Tyr Thr 
                565                 570                 575     

Ala Leu Leu Ile Lys Thr Leu Arg Gln Lys Ala Phe His Pro Ser Trp 
            580                 585                 590         

Glu Ala Tyr Pro Gly Asp Glu Asp Asn Gly Ser Leu Ser Ala Trp Tyr 
        595                 600                 605             

Ile Trp Ser Ala Leu Gly Phe Tyr Pro Thr Cys Pro Gly Lys Pro Ser 
    610                 615                 620                 

Tyr Asp Leu Gly Ile Pro Leu Phe Asp His Leu Arg Val Tyr Leu Ala 
625                 630                 635                 640 

Lys Glu Asp Lys Trp Leu Asp Ile His Thr Lys Gln Asn His Asn His 
                645                 650                 655     

Phe Asn Phe Val Lys Glu Cys Arg Leu Asp Lys Thr Leu Val Ser Thr 
            660                 665                 670         

Ile Gln His Gln Asp Leu Leu Lys Ala Glu Gln Leu Thr Phe Thr Leu 
        675                 680                 685             

Ser Trp Leu Pro Ser His 
    690                 

<210>   4497
<211>   1677
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4497
atgaagaaaa tcaaaccgca tggaccgtta ccaagtcaga ctcagctagc ttatctggga   60
gatgaactag cagcttttat ccacttcggt cctaatacct tttatgacca agaatggggg   120
actggacagg aggatcctga gcgctttaac ccgagtcagt tggatgcgcg tgagtgggtt   180
cgtgtgctca aggaaacggg cttcaaaaag ttgattttgg tggtcaagca ccacgatggc   240
tttgtccttt atccgacagc tcacacagat tattcggtta aggtcagtcc ttggaggaga   300
ggaaagggcg acttgctcct tgaagtatcc caagctgcca cagagtttga tatggatatg   360
ggggtctacc tgtcaccgtg ggatgcccat agtcccctct atcatgtgga ccgagaagcg   420
gactacaatg cctattatct ggctcagttg aaggaaatct tatcaaatcc taactatggg   480
aatgctggta agttcgctga ggtttggatg gatggtgcca gaggagaggg cgcgcaaaag   540
gttaattatg aatttgaaaa atggtttgaa accattcgtg acctgcaggg cgattgcttg   600
attttttcaa cagaaggcac cagtatccgc tggattggca atgaacgagg gtatgcaggt   660
gatccactgt ggcaaaaggt gaatcctgat aaactaggaa cagaagcaga gctgaactat   720
cttcagcacg gggatccctc gggcacgatt ttttcaatcg gagaggcaga tgtttccatc   780
cgtccaggct ggttctacca tgaggatcag gatcctaagt ctctcgagga gttggtcgaa   840
atctactttc actcagtagg gcgaggaact ccactcttgc ttaatattcc gccgaatcaa   900
gctgggctct ttgatgcaaa ggatattgaa cgactttatg aatttgcgac ctatcgcaat   960
gagctctata aagaagattt ggctctggga gctgaggtat ctggtccagc tctttccgca   1020
gactttgctt gtcgccattt gacagacggc cttgagacca gctcttgggc aagcgatgca   1080
gacttgccca tccagttaga actcgactta ggttctccta aaacttttga tgtaattgag   1140
ttaagagaag atttgaagct agggcaacga atcgctgctt ttcatgtgca agtagaggtg   1200
gatggtgtct ggcaggagtt tggttcgggt catactgttg gttacaaacg tctcttacga   1260
ggagcagttg ttgaggcaca gaagatacgt gtagtcatta cagaatcaca ggctttgcct   1320
ttgttgacca agatttccct ttataaaact cctggattat caaaaaaaga agttgttcag   1380
gaactagcat ttgcagaaaa aagcctagct gtggcaaagg gagaaaatgc ctattttaca   1440
gttaagcgca gagaatgtag tggtccttta gaagctaaga tttcgattca accggggaca   1500
ggtgtccatg gtgtcgccta tcaggatgag attcaagtcc ttgcgtttca aactggtgag   1560
actgaaaaaa gtctgacgct accaaccttg tatttcgcag gagataaaac cttggatttc   1620
tatctgaacc taacggtgga tggtcagctt gtggatcaac ttcaagtcca agtttca      1677

<210>   4498
<211>   559
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15903995 (0.E+01)

<400>   4498
Met Lys Lys Ile Lys Pro His Gly Pro Leu Pro Ser Gln Thr Gln Leu 
1               5                   10                  15      

Ala Tyr Leu Gly Asp Glu Leu Ala Ala Phe Ile His Phe Gly Pro Asn 
            20                  25                  30          

Thr Phe Tyr Asp Gln Glu Trp Gly Thr Gly Gln Glu Asp Pro Glu Arg 
        35                  40                  45              

Phe Asn Pro Ser Gln Leu Asp Ala Arg Glu Trp Val Arg Val Leu Lys 
    50                  55                  60                  

Glu Thr Gly Phe Lys Lys Leu Ile Leu Val Val Lys His His Asp Gly 
65                  70                  75                  80  

Phe Val Leu Tyr Pro Thr Ala His Thr Asp Tyr Ser Val Lys Val Ser 
                85                  90                  95      

Pro Trp Arg Arg Gly Lys Gly Asp Leu Leu Leu Glu Val Ser Gln Ala 
            100                 105                 110         

Ala Thr Glu Phe Asp Met Asp Met Gly Val Tyr Leu Ser Pro Trp Asp 
        115                 120                 125             

Ala His Ser Pro Leu Tyr His Val Asp Arg Glu Ala Asp Tyr Asn Ala 
    130                 135                 140                 

Tyr Tyr Leu Ala Gln Leu Lys Glu Ile Leu Ser Asn Pro Asn Tyr Gly 
145                 150                 155                 160 

Asn Ala Gly Lys Phe Ala Glu Val Trp Met Asp Gly Ala Arg Gly Glu 
                165                 170                 175     

Gly Ala Gln Lys Val Asn Tyr Glu Phe Glu Lys Trp Phe Glu Thr Ile 
            180                 185                 190         

Arg Asp Leu Gln Gly Asp Cys Leu Ile Phe Ser Thr Glu Gly Thr Ser 
        195                 200                 205             

Ile Arg Trp Ile Gly Asn Glu Arg Gly Tyr Ala Gly Asp Pro Leu Trp 
    210                 215                 220                 

Gln Lys Val Asn Pro Asp Lys Leu Gly Thr Glu Ala Glu Leu Asn Tyr 
225                 230                 235                 240 

Leu Gln His Gly Asp Pro Ser Gly Thr Ile Phe Ser Ile Gly Glu Ala 
                245                 250                 255     

Asp Val Ser Ile Arg Pro Gly Trp Phe Tyr His Glu Asp Gln Asp Pro 
            260                 265                 270         

Lys Ser Leu Glu Glu Leu Val Glu Ile Tyr Phe His Ser Val Gly Arg 
        275                 280                 285             

Gly Thr Pro Leu Leu Leu Asn Ile Pro Pro Asn Gln Ala Gly Leu Phe 

    290                 295                 300                 

Asp Ala Lys Asp Ile Glu Arg Leu Tyr Glu Phe Ala Thr Tyr Arg Asn 
305                 310                 315                 320 

Glu Leu Tyr Lys Glu Asp Leu Ala Leu Gly Ala Glu Val Ser Gly Pro 
                325                 330                 335     

Ala Leu Ser Ala Asp Phe Ala Cys Arg His Leu Thr Asp Gly Leu Glu 
            340                 345                 350         

Thr Ser Ser Trp Ala Ser Asp Ala Asp Leu Pro Ile Gln Leu Glu Leu 
        355                 360                 365             

Asp Leu Gly Ser Pro Lys Thr Phe Asp Val Ile Glu Leu Arg Glu Asp 
    370                 375                 380                 

Leu Lys Leu Gly Gln Arg Ile Ala Ala Phe His Val Gln Val Glu Val 
385                 390                 395                 400 

Asp Gly Val Trp Gln Glu Phe Gly Ser Gly His Thr Val Gly Tyr Lys 
                405                 410                 415     

Arg Leu Leu Arg Gly Ala Val Val Glu Ala Gln Lys Ile Arg Val Val 
            420                 425                 430         

Ile Thr Glu Ser Gln Ala Leu Pro Leu Leu Thr Lys Ile Ser Leu Tyr 
        435                 440                 445             

Lys Thr Pro Gly Leu Ser Lys Lys Glu Val Val Gln Glu Leu Ala Phe 
    450                 455                 460                 

Ala Glu Lys Ser Leu Ala Val Ala Lys Gly Glu Asn Ala Tyr Phe Thr 
465                 470                 475                 480 

Val Lys Arg Arg Glu Cys Ser Gly Pro Leu Glu Ala Lys Ile Ser Ile 
                485                 490                 495     

Gln Pro Gly Thr Gly Val His Gly Val Ala Tyr Gln Asp Glu Ile Gln 
            500                 505                 510         

Val Leu Ala Phe Gln Thr Gly Glu Thr Glu Lys Ser Leu Thr Leu Pro 
        515                 520                 525             

Thr Leu Tyr Phe Ala Gly Asp Lys Thr Leu Asp Phe Tyr Leu Asn Leu 
    530                 535                 540                 

Thr Val Asp Gly Gln Leu Val Asp Gln Leu Gln Val Gln Val Ser 
545                 550                 555                 

<210>   4499
<211>   222
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4499
atgcttctcc aaaatctatc ttcaaaagaa tgttgcatct ttttatcctt tcacacaaac   60
atttctcttt atacagatcc aagtgataac cagatgataa ttggacactt tttgatcatt   120
tgtatatttt ttgaaaaatt ttttaaaaaa attttatatc ctttttatag aagtttatgc   180
atttgtatct atgtattcta tcctatgtta tgtataataa ca                      222

<210>   4500
<211>   74
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   4500
Met Leu Leu Gln Asn Leu Ser Ser Lys Glu Cys Cys Ile Phe Leu Ser 
1               5                   10                  15      

Phe His Thr Asn Ile Ser Leu Tyr Thr Asp Pro Ser Asp Asn Gln Met 
            20                  25                  30          

Ile Ile Gly His Phe Leu Ile Ile Cys Ile Phe Phe Glu Lys Phe Phe 
        35                  40                  45              

Lys Lys Ile Leu Tyr Pro Phe Tyr Arg Ser Leu Cys Ile Cys Ile Tyr 
    50                  55                  60                  

Val Phe Tyr Pro Met Leu Cys Ile Ile Thr 
65                  70                  

<210>   4501
<211>   1227
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4501
atgtcttcac atccaattca ggtcttctca gaaattggga aactgaaaaa agttatgttg   60
caccgtccag gcaaggagtt agaaaacttg ttgccggact atcttgaaag gcttcttttt   120
gatgatattc ctttcttgga agatgctcaa aaagaacatg atgcatttgc ccaagctctt   180
cgcgatgaag gaattgaggt tctctaccta gaacaactcg ctgctgaatc attgacctct   240
ccagaaatcc gcgatcaatt tatcgaggaa tacttagacg aagccaacat ccgtgatcgt   300
caaaccaagg ttgctattcg tgaattgctt cacggcatca aggacaacca agaattggtt   360
gaaaaaacaa tggctgggat tcaaaaagtt gaattgccag aaattcctga cgaagctaaa   420
gatctaactg acttagttga atcagagtat ccatttgcaa ttgacccgat gccaaacctc   480
tatttcactc gcgacccatt tgcaacaatt ggaaacgccg tatcgcttaa ccacatgttt   540
gcagacactc gtaaccgtga aacactctac ggtaagtata tcttcaaata ccacccaatc   600
tatggcggaa aagtggattt ggtctacaac cgtgaagaag atacgcgtat cgaaggtgga   660
gacgagttag ttctttctaa agacgtcctt gcagtaggta tctctcaacg tacagacgca   720
gcttctatcg aaaaactttt ggtcaacatc ttcaagaaaa atgttggctt caagaaagtt   780
ttggcctttg aatttgctaa caaccgtaaa ttcatgcact tggatactgt cttcactatg   840
gtagactatg acaagttcac tattcaccca gaaatcgaag gcgaccttca cgtttactca   900
gttacttacg aaaacgaaaa acttaaaatc gttgaagaga aaggtgactt agctgaactt   960
cttgctcaaa accttggtgt agaaaaagtt catttgattc gttgcggtgg tggcaatatc   1020
gtagcagctg cgcgtgaaca atggaacgac ggttctaaca ctttgaccat cgcacctggt   1080
gtggtagttg tttatgaccg caataccgtg accaataaga ttttggaaga atacgggctt   1140
cgcttgatta agattcgcgg aagtgaattg gttcggggcc gtggtggacc tcgttgtatg   1200
tctatgccat ttgaacgtga agaagtg                                       1227

<210>   4502
<211>   409
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   arginine deiminase (arcA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903996 (e-139)

<400>   4502
Met Ser Ser His Pro Ile Gln Val Phe Ser Glu Ile Gly Lys Leu Lys 
1               5                   10                  15      

Lys Val Met Leu His Arg Pro Gly Lys Glu Leu Glu Asn Leu Leu Pro 
            20                  25                  30          

Asp Tyr Leu Glu Arg Leu Leu Phe Asp Asp Ile Pro Phe Leu Glu Asp 
        35                  40                  45              

Ala Gln Lys Glu His Asp Ala Phe Ala Gln Ala Leu Arg Asp Glu Gly 
    50                  55                  60                  

Ile Glu Val Leu Tyr Leu Glu Gln Leu Ala Ala Glu Ser Leu Thr Ser 
65                  70                  75                  80  

Pro Glu Ile Arg Asp Gln Phe Ile Glu Glu Tyr Leu Asp Glu Ala Asn 
                85                  90                  95      

Ile Arg Asp Arg Gln Thr Lys Val Ala Ile Arg Glu Leu Leu His Gly 
            100                 105                 110         

Ile Lys Asp Asn Gln Glu Leu Val Glu Lys Thr Met Ala Gly Ile Gln 
        115                 120                 125             

Lys Val Glu Leu Pro Glu Ile Pro Asp Glu Ala Lys Asp Leu Thr Asp 
    130                 135                 140                 

Leu Val Glu Ser Glu Tyr Pro Phe Ala Ile Asp Pro Met Pro Asn Leu 
145                 150                 155                 160 

Tyr Phe Thr Arg Asp Pro Phe Ala Thr Ile Gly Asn Ala Val Ser Leu 
                165                 170                 175     

Asn His Met Phe Ala Asp Thr Arg Asn Arg Glu Thr Leu Tyr Gly Lys 
            180                 185                 190         

Tyr Ile Phe Lys Tyr His Pro Ile Tyr Gly Gly Lys Val Asp Leu Val 
        195                 200                 205             

Tyr Asn Arg Glu Glu Asp Thr Arg Ile Glu Gly Gly Asp Glu Leu Val 
    210                 215                 220                 

Leu Ser Lys Asp Val Leu Ala Val Gly Ile Ser Gln Arg Thr Asp Ala 
225                 230                 235                 240 

Ala Ser Ile Glu Lys Leu Leu Val Asn Ile Phe Lys Lys Asn Val Gly 
                245                 250                 255     

Phe Lys Lys Val Leu Ala Phe Glu Phe Ala Asn Asn Arg Lys Phe Met 
            260                 265                 270         

His Leu Asp Thr Val Phe Thr Met Val Asp Tyr Asp Lys Phe Thr Ile 
        275                 280                 285             

His Pro Glu Ile Glu Gly Asp Leu His Val Tyr Ser Val Thr Tyr Glu 
    290                 295                 300                 

Asn Glu Lys Leu Lys Ile Val Glu Glu Lys Gly Asp Leu Ala Glu Leu 
305                 310                 315                 320 

Leu Ala Gln Asn Leu Gly Val Glu Lys Val His Leu Ile Arg Cys Gly 
                325                 330                 335     

Gly Gly Asn Ile Val Ala Ala Ala Arg Glu Gln Trp Asn Asp Gly Ser 
            340                 345                 350         

Asn Thr Leu Thr Ile Ala Pro Gly Val Val Val Val Tyr Asp Arg Asn 
        355                 360                 365             

Thr Val Thr Asn Lys Ile Leu Glu Glu Tyr Gly Leu Arg Leu Ile Lys 
    370                 375                 380                 

Ile Arg Gly Ser Glu Leu Val Arg Gly Arg Gly Gly Pro Arg Cys Met 
385                 390                 395                 400 

Ser Met Pro Phe Glu Arg Glu Glu Val 
                405                 

<210>   4503
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4503
ttgtcatttt attatttcct ctttctattt tttacatttt ctattgacga atatcgaaca   60
gcgattacac ttcttcacgt tcaaatggca                                    90

<210>   4504
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4504
Met Ser Phe Tyr Tyr Phe Leu Phe Leu Phe Phe Thr Phe Ser Ile Asp 
1               5                   10                  15      

Glu Tyr Arg Thr Ala Ile Thr Leu Leu His Val Gln Met Ala 
            20                  25                  30  

<210>   4505
<211>   1014
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4505
atgacaaatt cagtattcca aggacgcagc ttcttagcag aaaaagactt tacccgtgca   60
gagttagaat accttattgg tctttcagct cacttgaaag atttgaaaaa acgcaatatt   120
caacaccact accttgctgg caagaatatc gctctcctat ttgaaaaaac atctactcgt   180
actcgtgcag cctttacaac tgcggctatc gaccttggtg ctcacccaga atacctcgga   240
gcaaatgata ttcagttggg taaaaaagaa tctactgaag atactgctaa agtattggga   300
cgtatgtttg acgggattga attccgcgga ttcagccaac gtatggttga agaattggca   360
gaattctcag gcgttccagt atggaacggt ctaactgacg aatggcaccc aactcaaatg   420
ctcgctgact acttgactgt tcaagaaaac ttcggtcgct tggaaggctt gacattggta   480
tactgtggtg atggacgtaa caacgttgcc aacagcttgc tcgtaacagg tgctatcctt   540
ggtgtcaatg ttcacatctt ctcaccaaaa gaactcttcc cagaaaaaga aatcgttgaa   600
ttggcagaag gatttgctaa agaaagtggc gcacatgttc tcatcactga agatgctgat   660
gaagcagtta aagatgcaga cgttctttac acagacgttt gggtatcaat gggtgaagaa   720
gacaaattcg cagaacgtgt agctcttctt aaaccttacc aagtcaatat ggacttagtt   780
aaaaaagcag gcaatgaaaa cttgatcttc ctacactgct tgccagcatt ccacgatact   840
cacactgttt atggtaaaga cgttgctgaa aaatttggtg tagaagaaat ggaagtaaca   900
gacgaagtct tccgcagcaa gtacgctcgc cacttcgatc aagcagaaaa ccgtatgcac   960
actatcaaag ctgttatggc tgctacactt ggtaaccttt atattcctaa agta         1014

<210>   4506
<211>   338
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ornithine carbamoyltransferase (argF)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15903998 (0.E+01)

<400>   4506
Met Thr Asn Ser Val Phe Gln Gly Arg Ser Phe Leu Ala Glu Lys Asp 
1               5                   10                  15      

Phe Thr Arg Ala Glu Leu Glu Tyr Leu Ile Gly Leu Ser Ala His Leu 
            20                  25                  30          

Lys Asp Leu Lys Lys Arg Asn Ile Gln His His Tyr Leu Ala Gly Lys 
        35                  40                  45              

Asn Ile Ala Leu Leu Phe Glu Lys Thr Ser Thr Arg Thr Arg Ala Ala 
    50                  55                  60                  

Phe Thr Thr Ala Ala Ile Asp Leu Gly Ala His Pro Glu Tyr Leu Gly 
65                  70                  75                  80  

Ala Asn Asp Ile Gln Leu Gly Lys Lys Glu Ser Thr Glu Asp Thr Ala 
                85                  90                  95      

Lys Val Leu Gly Arg Met Phe Asp Gly Ile Glu Phe Arg Gly Phe Ser 
            100                 105                 110         

Gln Arg Met Val Glu Glu Leu Ala Glu Phe Ser Gly Val Pro Val Trp 
        115                 120                 125             

Asn Gly Leu Thr Asp Glu Trp His Pro Thr Gln Met Leu Ala Asp Tyr 
    130                 135                 140                 

Leu Thr Val Gln Glu Asn Phe Gly Arg Leu Glu Gly Leu Thr Leu Val 
145                 150                 155                 160 

Tyr Cys Gly Asp Gly Arg Asn Asn Val Ala Asn Ser Leu Leu Val Thr 
                165                 170                 175     

Gly Ala Ile Leu Gly Val Asn Val His Ile Phe Ser Pro Lys Glu Leu 
            180                 185                 190         

Phe Pro Glu Lys Glu Ile Val Glu Leu Ala Glu Gly Phe Ala Lys Glu 
        195                 200                 205             

Ser Gly Ala His Val Leu Ile Thr Glu Asp Ala Asp Glu Ala Val Lys 
    210                 215                 220                 

Asp Ala Asp Val Leu Tyr Thr Asp Val Trp Val Ser Met Gly Glu Glu 
225                 230                 235                 240 

Asp Lys Phe Ala Glu Arg Val Ala Leu Leu Lys Pro Tyr Gln Val Asn 
                245                 250                 255     

Met Asp Leu Val Lys Lys Ala Gly Asn Glu Asn Leu Ile Phe Leu His 
            260                 265                 270         

Cys Leu Pro Ala Phe His Asp Thr His Thr Val Tyr Gly Lys Asp Val 
        275                 280                 285             

Ala Glu Lys Phe Gly Val Glu Glu Met Glu Val Thr Asp Glu Val Phe 
    290                 295                 300                 

Arg Ser Lys Tyr Ala Arg His Phe Asp Gln Ala Glu Asn Arg Met His 
305                 310                 315                 320 

Thr Ile Lys Ala Val Met Ala Ala Thr Leu Gly Asn Leu Tyr Ile Pro 
                325                 330                 335     

Lys Val 
        

<210>   4507
<211>   945
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4507
atggcaaatc gtaaaattgt agtagctttg ggaggaaatg cgattctttc ttctgaccca   60
tcagcaaagg ctcaacaaga agctttagtt gaaacagcta agcatcttgt aaaattgatt   120
aaaaatggag atgatctgat tatcactcac ggtaatggac ctcaagttgg gaatctcttg   180
ctccaacatt tggcatcaga ctctgaaaag aaccctgcct tcccactcga ctcacttgtc   240
gctatgacag aaggtagcat cggtttctgg ttgaaaaatg ctttgcaaaa tgctctcttg   300
gatgaaggca tcgaaaaaaa tgttgcctct gttgtaacgc aagttgtcgt agataaaaat   360
gatccagctt ttgttaactt gagtaaacca atcggtcctt tctattcaga agaagaagca   420
aaagcagaag ccgaaaaaag cggagcgact ttcaaggaag atgctggccg tggctggcgt   480
aaggtcgttg cctcaccaaa acctgttgac atcaaagaaa ttgaaaccat ccgtactctt   540
ttaaataatg gtcaagtcgt cgtagctgca ggtggtggcg gtattcccgt cgtcaaagaa   600
aacaatggac atttgactgg tgtcgaagcg gttattgata aagacttcgc ttcccaacgt   660
ttggcagaat tggttgatgc agacctcttc atcgttttga caggtgtaga ttatgtattt   720
gttaactaca acaagccaaa ccaggaaaaa ttggaacatg tgaatgttgc ccagctggaa   780
gaatatatca aacaagatca gtttgcacca ggtagcatgc ttccaaaagt agaagcagct   840
atcgcttttg tcaatggtcg tccagaagga aaagcagtta ttacttccct tgaaaatcta   900
ggcgccttga ttgaatctga aagcggaaca attattgaaa aagga                   945

<210>   4508
<211>   315
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   carbamate kinase (arcC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903999 (e-177)

<400>   4508
Met Ala Asn Arg Lys Ile Val Val Ala Leu Gly Gly Asn Ala Ile Leu 
1               5                   10                  15      

Ser Ser Asp Pro Ser Ala Lys Ala Gln Gln Glu Ala Leu Val Glu Thr 
            20                  25                  30          

Ala Lys His Leu Val Lys Leu Ile Lys Asn Gly Asp Asp Leu Ile Ile 
        35                  40                  45              

Thr His Gly Asn Gly Pro Gln Val Gly Asn Leu Leu Leu Gln His Leu 
    50                  55                  60                  

Ala Ser Asp Ser Glu Lys Asn Pro Ala Phe Pro Leu Asp Ser Leu Val 
65                  70                  75                  80  

Ala Met Thr Glu Gly Ser Ile Gly Phe Trp Leu Lys Asn Ala Leu Gln 
                85                  90                  95      

Asn Ala Leu Leu Asp Glu Gly Ile Glu Lys Asn Val Ala Ser Val Val 
            100                 105                 110         

Thr Gln Val Val Val Asp Lys Asn Asp Pro Ala Phe Val Asn Leu Ser 
        115                 120                 125             

Lys Pro Ile Gly Pro Phe Tyr Ser Glu Glu Glu Ala Lys Ala Glu Ala 
    130                 135                 140                 

Glu Lys Ser Gly Ala Thr Phe Lys Glu Asp Ala Gly Arg Gly Trp Arg 
145                 150                 155                 160 

Lys Val Val Ala Ser Pro Lys Pro Val Asp Ile Lys Glu Ile Glu Thr 
                165                 170                 175     

Ile Arg Thr Leu Leu Asn Asn Gly Gln Val Val Val Ala Ala Gly Gly 
            180                 185                 190         

Gly Gly Ile Pro Val Val Lys Glu Asn Asn Gly His Leu Thr Gly Val 
        195                 200                 205             

Glu Ala Val Ile Asp Lys Asp Phe Ala Ser Gln Arg Leu Ala Glu Leu 
    210                 215                 220                 

Val Asp Ala Asp Leu Phe Ile Val Leu Thr Gly Val Asp Tyr Val Phe 
225                 230                 235                 240 

Val Asn Tyr Asn Lys Pro Asn Gln Glu Lys Leu Glu His Val Asn Val 
                245                 250                 255     

Ala Gln Leu Glu Glu Tyr Ile Lys Gln Asp Gln Phe Ala Pro Gly Ser 
            260                 265                 270         

Met Leu Pro Lys Val Glu Ala Ala Ile Ala Phe Val Asn Gly Arg Pro 
        275                 280                 285             

Glu Gly Lys Ala Val Ile Thr Ser Leu Glu Asn Leu Gly Ala Leu Ile 
    290                 295                 300                 

Glu Ser Glu Ser Gly Thr Ile Ile Glu Lys Gly 
305                 310                 315 

<210>   4509
<211>   1509
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4509
atgagtgaaa aagctaaaaa agggtttaag atgccttcat cttacaccgt attattgata   60
atcattgcta ttatggcagt gctaacttgg tttatccctg cgggggcctt tatagaaggt   120
atttacgaga ctcagcctca aaatccacaa gggatttggg atgtcctcat ggcaccgatt   180
cgggctatgc taggtactca tccagaggaa ggttcgctca ttaaagaaac gagcgcagcg   240
attgatgtag ccttcttcat ccttatggtt ggtggtttcc ttggcattgt caacaaaact   300
ggtgctcttg acgtagggat tgcctctatc gtgaagaagt ataagggccg cgaaaaaatg   360
ttaattttgg tactgatgcc tttgtttgcc ctcggtggta caacttatgg tatgggtgaa   420
gaaacaatgg ccttctatcc actccttgtg ccagttatga tggccgttgg ttttgatagc   480
ctgactggtg ttgcaattat tttgctcggt tctcaaatcg gctgtttggc atctactctg   540
aatccatttg cgacaggtat tgcttcagcg actgcgggag ttggtacagg ggacggtatc   600
gtacttcgtc tgatcttctg ggttaccttg actgctctta gtacttggtt tgtttaccgt   660
tatgcggata agattcaaaa agatccgact aagtcactgg tttatagtac tcgcaaagaa   720
gatttgaaac actttaacgt agaagaatct tcatctgtag aatctacact tagcagcaaa   780
caaaaatcag ttctcttctt atttgtgttg acattcatct tgatggtatt gagcttcatt   840
ccatggacag accttggcgt taccattttt gatgacttta atacttggtt gactggtctt   900
ccagttattg gtaatattgt cggttcatct acttctgcac taggtacttg gtacttccca   960
gaaggcgcaa tgctctttgc ctttatgggt atcctgattg gtgttattta tggtcttaaa   1020
gaagataaga ttatctcttc cttcatgaat ggtgctgctg acttgctcag tgttgccttg   1080
atcgtagcga ttgctcgtgg tattcaagtt atcatgaacg acggtatgat taccgataca   1140
atcctcaact ggggtaaaga aggcttgagc ggtctatctt cacaagtctt tatcgttgta   1200
acttatatct tctatctacc tatgtcattc ttgatcccat cttcatctgg tcttgccagc   1260
gcaactatgg gtatcatggc tccacttgga gaatttgtaa atgtccgtcc tagcttgatt   1320
atcactgctt accaatctgc ttcaggtgtc ttgaacttga ttgcaccaac atctggtatt   1380
gtgatgggag ctcttgcact tggacgtatc aacattggta cttggtggaa attcatgggc   1440
aaactcgtag tcgctattat tgtagtgacc atcgcccttc ttctccttgg aaccttcctt   1500
ccattccta                                                           1509

<210>   4510
<211>   503
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904000 (0.E+01)

<400>   4510
Met Ser Glu Lys Ala Lys Lys Gly Phe Lys Met Pro Ser Ser Tyr Thr 
1               5                   10                  15      

Val Leu Leu Ile Ile Ile Ala Ile Met Ala Val Leu Thr Trp Phe Ile 
            20                  25                  30          

Pro Ala Gly Ala Phe Ile Glu Gly Ile Tyr Glu Thr Gln Pro Gln Asn 
        35                  40                  45              

Pro Gln Gly Ile Trp Asp Val Leu Met Ala Pro Ile Arg Ala Met Leu 
    50                  55                  60                  

Gly Thr His Pro Glu Glu Gly Ser Leu Ile Lys Glu Thr Ser Ala Ala 
65                  70                  75                  80  

Ile Asp Val Ala Phe Phe Ile Leu Met Val Gly Gly Phe Leu Gly Ile 
                85                  90                  95      

Val Asn Lys Thr Gly Ala Leu Asp Val Gly Ile Ala Ser Ile Val Lys 
            100                 105                 110         

Lys Tyr Lys Gly Arg Glu Lys Met Leu Ile Leu Val Leu Met Pro Leu 
        115                 120                 125             

Phe Ala Leu Gly Gly Thr Thr Tyr Gly Met Gly Glu Glu Thr Met Ala 
    130                 135                 140                 

Phe Tyr Pro Leu Leu Val Pro Val Met Met Ala Val Gly Phe Asp Ser 
145                 150                 155                 160 

Leu Thr Gly Val Ala Ile Ile Leu Leu Gly Ser Gln Ile Gly Cys Leu 
                165                 170                 175     

Ala Ser Thr Leu Asn Pro Phe Ala Thr Gly Ile Ala Ser Ala Thr Ala 
            180                 185                 190         

Gly Val Gly Thr Gly Asp Gly Ile Val Leu Arg Leu Ile Phe Trp Val 
        195                 200                 205             

Thr Leu Thr Ala Leu Ser Thr Trp Phe Val Tyr Arg Tyr Ala Asp Lys 
    210                 215                 220                 


Ile Gln Lys Asp Pro Thr Lys Ser Leu Val Tyr Ser Thr Arg Lys Glu 
225                 230                 235                 240 

Asp Leu Lys His Phe Asn Val Glu Glu Ser Ser Ser Val Glu Ser Thr 
                245                 250                 255     

Leu Ser Ser Lys Gln Lys Ser Val Leu Phe Leu Phe Val Leu Thr Phe 
            260                 265                 270         

Ile Leu Met Val Leu Ser Phe Ile Pro Trp Thr Asp Leu Gly Val Thr 
        275                 280                 285             

Ile Phe Asp Asp Phe Asn Thr Trp Leu Thr Gly Leu Pro Val Ile Gly 
    290                 295                 300                 

Asn Ile Val Gly Ser Ser Thr Ser Ala Leu Gly Thr Trp Tyr Phe Pro 
305                 310                 315                 320 

Glu Gly Ala Met Leu Phe Ala Phe Met Gly Ile Leu Ile Gly Val Ile 
                325                 330                 335     

Tyr Gly Leu Lys Glu Asp Lys Ile Ile Ser Ser Phe Met Asn Gly Ala 
            340                 345                 350         

Ala Asp Leu Leu Ser Val Ala Leu Ile Val Ala Ile Ala Arg Gly Ile 
        355                 360                 365             

Gln Val Ile Met Asn Asp Gly Met Ile Thr Asp Thr Ile Leu Asn Trp 
    370                 375                 380                 

Gly Lys Glu Gly Leu Ser Gly Leu Ser Ser Gln Val Phe Ile Val Val 
385                 390                 395                 400 

Thr Tyr Ile Phe Tyr Leu Pro Met Ser Phe Leu Ile Pro Ser Ser Ser 
                405                 410                 415     

Gly Leu Ala Ser Ala Thr Met Gly Ile Met Ala Pro Leu Gly Glu Phe 
            420                 425                 430         

Val Asn Val Arg Pro Ser Leu Ile Ile Thr Ala Tyr Gln Ser Ala Ser 
        435                 440                 445             

Gly Val Leu Asn Leu Ile Ala Pro Thr Ser Gly Ile Val Met Gly Ala 
    450                 455                 460                 

Leu Ala Leu Gly Arg Ile Asn Ile Gly Thr Trp Trp Lys Phe Met Gly 
465                 470                 475                 480 

Lys Leu Val Val Ala Ile Ile Val Val Thr Ile Ala Leu Leu Leu Leu 
                485                 490                 495     

Gly Thr Phe Leu Pro Phe Leu 
            500             

<210>   4511
<211>   1329
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4511
atgaaaatag atataacaaa tcaagttaaa gatgaatttc ttatatcatt aaaaaccttg   60
atttcctatc cttcagtact caatgaagga gaaaatggaa caccttttgg acaagcaatc   120
caagatgtcc tagaaaaaac tttagagatt tgtcgagaca taggtttcac tacctatctt   180
gaccctaaag gttattacgg atatgcagaa atcggtcagg gagcagagct tctggccatt   240
ctctgtcatt tggatgttgt tccatcaggt gatgaagcag attggcagac accgccattt   300
gaagcaacta tcaaagacgg ctgggtattc ggacgtggtg tccaagatga taaaggccct   360
tcgctcgcag ctctctatgc agtaaaaagc ttgctggacc aaggtattca gttcaaaaag   420
cgcgtacgct ttatctttgg taccgatgag gaaaccctct ggcgctgcat ggcacgctac   480
aataccatcg aagaacaggc cagtatgggc tttgcacctg actcatcttt tcctctgacc   540
tatgctgaaa aagggcttct acaggtcaaa cttcatggcc ctggatcgga tcaactagag   600
cttgaagtag gaggcgcctt taacgttgta ccagacaagg ccaactacca aggtctcctc   660
tatgaacagg tttgtaacgg tctcaaagaa gctggttatg attaccaaac cactgaacaa   720
accgtaacgg ttctcggagt gccaaagcat gctaaggatg ctagtcaagg tatcaatgct   780
gtcatccgac tagctaccat tcttgctcct ctccaagaac accctgctct cagttttctt   840
gcaacacaag caggtcaaga cggcacagga agacaaatct ttggtgatat agcagatgaa   900
ccttctggtc acctatcctt taatgtcgca ggtctcatga tcaatcatga acgttctgaa   960
atccgtattg acattcggac tcctgtctta gctgacaagg aagaactagt agagttgctt   1020
acaagatgtg cacaaaacta ccaactccgc tacgaagagt ttgactatct agcgcctcta   1080
tacgtcgcag aagacagtaa actcgttagc acactgatgc aaatctacca agaaaagact   1140
ggcgataaca gtcctgctat ttcatccggt ggtgccactt ttgctcgcac catgccaaat   1200
tgtgtagcct tcggcgcctt attcccagga gcgaagcaga cagaacatca ggcaaatgaa   1260
tgtgccgttc tagaagattt gtaccgtgct atggatattt atgccgaagc cgtctatcga   1320
cttgcaact                                                           1329

<210>   4512
<211>   443
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidase, M20/M25/M40 family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904001 (0.E+01)

<400>   4512
Met Lys Ile Asp Ile Thr Asn Gln Val Lys Asp Glu Phe Leu Ile Ser 
1               5                   10                  15      

Leu Lys Thr Leu Ile Ser Tyr Pro Ser Val Leu Asn Glu Gly Glu Asn 
            20                  25                  30          

Gly Thr Pro Phe Gly Gln Ala Ile Gln Asp Val Leu Glu Lys Thr Leu 
        35                  40                  45              

Glu Ile Cys Arg Asp Ile Gly Phe Thr Thr Tyr Leu Asp Pro Lys Gly 
    50                  55                  60                  

Tyr Tyr Gly Tyr Ala Glu Ile Gly Gln Gly Ala Glu Leu Leu Ala Ile 
65                  70                  75                  80  

Leu Cys His Leu Asp Val Val Pro Ser Gly Asp Glu Ala Asp Trp Gln 
                85                  90                  95      

Thr Pro Pro Phe Glu Ala Thr Ile Lys Asp Gly Trp Val Phe Gly Arg 
            100                 105                 110         

Gly Val Gln Asp Asp Lys Gly Pro Ser Leu Ala Ala Leu Tyr Ala Val 
        115                 120                 125             

Lys Ser Leu Leu Asp Gln Gly Ile Gln Phe Lys Lys Arg Val Arg Phe 
    130                 135                 140                 

Ile Phe Gly Thr Asp Glu Glu Thr Leu Trp Arg Cys Met Ala Arg Tyr 
145                 150                 155                 160 

Asn Thr Ile Glu Glu Gln Ala Ser Met Gly Phe Ala Pro Asp Ser Ser 
                165                 170                 175     

Phe Pro Leu Thr Tyr Ala Glu Lys Gly Leu Leu Gln Val Lys Leu His 
            180                 185                 190         

Gly Pro Gly Ser Asp Gln Leu Glu Leu Glu Val Gly Gly Ala Phe Asn 
        195                 200                 205             

Val Val Pro Asp Lys Ala Asn Tyr Gln Gly Leu Leu Tyr Glu Gln Val 
    210                 215                 220                 

Cys Asn Gly Leu Lys Glu Ala Gly Tyr Asp Tyr Gln Thr Thr Glu Gln 
225                 230                 235                 240 

Thr Val Thr Val Leu Gly Val Pro Lys His Ala Lys Asp Ala Ser Gln 
                245                 250                 255     


Gly Ile Asn Ala Val Ile Arg Leu Ala Thr Ile Leu Ala Pro Leu Gln 
            260                 265                 270         

Glu His Pro Ala Leu Ser Phe Leu Ala Thr Gln Ala Gly Gln Asp Gly 
        275                 280                 285             

Thr Gly Arg Gln Ile Phe Gly Asp Ile Ala Asp Glu Pro Ser Gly His 
    290                 295                 300                 

Leu Ser Phe Asn Val Ala Gly Leu Met Ile Asn His Glu Arg Ser Glu 
305                 310                 315                 320 

Ile Arg Ile Asp Ile Arg Thr Pro Val Leu Ala Asp Lys Glu Glu Leu 
                325                 330                 335     

Val Glu Leu Leu Thr Arg Cys Ala Gln Asn Tyr Gln Leu Arg Tyr Glu 
            340                 345                 350         

Glu Phe Asp Tyr Leu Ala Pro Leu Tyr Val Ala Glu Asp Ser Lys Leu 
        355                 360                 365             

Val Ser Thr Leu Met Gln Ile Tyr Gln Glu Lys Thr Gly Asp Asn Ser 
    370                 375                 380                 

Pro Ala Ile Ser Ser Gly Gly Ala Thr Phe Ala Arg Thr Met Pro Asn 
385                 390                 395                 400 

Cys Val Ala Phe Gly Ala Leu Phe Pro Gly Ala Lys Gln Thr Glu His 
                405                 410                 415     

Gln Ala Asn Glu Cys Ala Val Leu Glu Asp Leu Tyr Arg Ala Met Asp 
            420                 425                 430         

Ile Tyr Ala Glu Ala Val Tyr Arg Leu Ala Thr 
        435                 440             

<210>   4513
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4513
ttggggtgtt ttattatgaa attgagttat gaagataaag ttcagatcta tgaactaaga   60
aagcaaggac aaagcttcaa acagctttca aaaagatttg gtgtggatgt ttctggtcta   120
aagtcatctg aatctttgag a                                             141

<210>   4514
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, hypothetical protein, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902399 (2.E-09)

<400>   4514
Met Gly Cys Phe Ile Met Lys Leu Ser Tyr Glu Asp Lys Val Gln Ile 
1               5                   10                  15      

Tyr Glu Leu Arg Lys Gln Gly Gln Ser Phe Lys Gln Leu Ser Lys Arg 
            20                  25                  30          

Phe Gly Val Asp Val Ser Gly Leu Lys Ser Ser Glu Ser Leu Arg 
        35                  40                  45          

<210>   4515
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4515
ttgaaggctg cttatgtttt tcctaagatt ttttcaaaaa tatatttatc agatagcggt   60
ttgtcttctt cttcagcttg gtttttgtat                                    90

<210>   4516
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4516
Met Lys Ala Ala Tyr Val Phe Pro Lys Ile Phe Ser Lys Ile Tyr Leu 
1               5                   10                  15      

Ser Asp Ser Gly Leu Ser Ser Ser Ser Ala Trp Phe Leu Tyr 
            20                  25                  30  

<210>   4517
<211>   96
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4517
atgaaggatt tgttccttat gtttcaaatt aatacaaaaa ccaagctgaa gaagaagaca   60
aaccgctatc tgataaatat atttttgaaa aaatct                             96

<210>   4518
<211>   32
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4518
Met Lys Asp Leu Phe Leu Met Phe Gln Ile Asn Thr Lys Thr Lys Leu 
1               5                   10                  15      

Lys Lys Lys Thr Asn Arg Tyr Leu Ile Asn Ile Phe Leu Lys Lys Ser 
            20                  25                  30          


<210>   4519
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4519
atgatgggag atgggatgaa agaatttcaa tttgagagaa agcagcgttt ttctttgagg   60
ccatatgcaa taggagcttg ttcggtcttg ctaggaacga gtttattttt tgctggtatg   120
ggtgctcagc ctgtacagga tacagaaacg agttcagcac taatttcaag tcattatttg   180
gatgagcagg atttatctga aaagctgaaa tctgagttgc aatggtttga attagaaaac   240
aagcttttga acttatggga gcat                                          264

<210>   4520
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein

<400>   4520
Met Met Gly Asp Gly Met Lys Glu Phe Gln Phe Glu Arg Lys Gln Arg 
1               5                   10                  15      

Phe Ser Leu Arg Pro Tyr Ala Ile Gly Ala Cys Ser Val Leu Leu Gly 
            20                  25                  30          

Thr Ser Leu Phe Phe Ala Gly Met Gly Ala Gln Pro Val Gln Asp Thr 
        35                  40                  45              

Glu Thr Ser Ser Ala Leu Ile Ser Ser His Tyr Leu Asp Glu Gln Asp 
    50                  55                  60                  

Leu Ser Glu Lys Leu Lys Ser Glu Leu Gln Trp Phe Glu Leu Glu Asn 
65                  70                  75                  80  

Lys Leu Leu Asn Leu Trp Glu His 
                85              

<210>   4521
<211>   183
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4521
atgttactga cttcgtcagt tctatctgca acctcaaaac agtgttttga gctgacttcg   60
tcagttctat ctgcaacctc aaaacggtgt tttgagcaac ctgtggctag tttcctaatt   120
tgctctttga ttttcattga gtacaaagag cttggtaaca ggctcttttt gtattgcgtt   180
tat                                                                 183

<210>   4522
<211>   61
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4522
Met Leu Leu Thr Ser Ser Val Leu Ser Ala Thr Ser Lys Gln Cys Phe 
1               5                   10                  15      

Glu Leu Thr Ser Ser Val Leu Ser Ala Thr Ser Lys Arg Cys Phe Glu 
            20                  25                  30          

Gln Pro Val Ala Ser Phe Leu Ile Cys Ser Leu Ile Phe Ile Glu Tyr 
        35                  40                  45              

Lys Glu Leu Gly Asn Arg Leu Phe Leu Tyr Cys Val Tyr 
    50                  55                  60      

<210>   4523
<211>   165
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4523
ttgtactcaa tgaaaatcaa agagcaaatt aggaaactag ccacaggttg ctcaaaacac   60
cgttttgagg ttgcagatag aactgacgaa gtcagctcaa aacactgttt tgaggttgca   120
gatagaactg acgaagtcag taacatctat acggcaaggc gacgc                   165

<210>   4524
<211>   55
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4524
Met Tyr Ser Met Lys Ile Lys Glu Gln Ile Arg Lys Leu Ala Thr Gly 
1               5                   10                  15      

Cys Ser Lys His Arg Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser 
            20                  25                  30          

Ser Lys His Cys Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser Asn 
        35                  40                  45              

Ile Tyr Thr Ala Arg Arg Arg 
    50                  55  

<210>   4525
<211>   897
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4525
atggcaatat ttttcatgat ttttctgatt gtttgtgtgc tcctattggt gatagtcaca   60
ctgagtacag tttatgtggt tcgtcagcag tcggtggcga ttattgaacg ctttgggaaa   120
taccaaaagg ttgctaatag cggtattcat attcgcttgc cttttgggat tgactcgatt   180
gcagcacgga ttcagttgcg cttgttgcaa agtgatattg tggttgagac taagaccaag   240
gacaatgtgt tcgttatgat gaatgtagcg actcagtacc gtgtcaacga gcagagcgtg   300
acagatgctt actataaact catacgtcca gaatctcaga ttaaatctta tatcgaagat   360
gctcttcgct cttctgttcc aaaattaacc ttggatgaat tgtttgagaa aaaagatgag   420
attgcccttg aagttcaaca ccaagtagca gaagaaatga ccacttacgg ctacattatc   480
gtgaaaacct tgattaccaa ggtcgaacca gatgcagaag ttaagcaatc catgaatgaa   540
atcaatgcgg cgcaacgtaa gcgggtcgca gcacaagaat tggcggaagc tgacaagatt   600
aaaattgtca ctgcagctga agcagaagca gaaaaagacc gccttcatgg tgtggggatt   660
gcccaacaac gtaaggcgat tgtggatgga ttggcagagt ctatcaccga actcaaggaa   720
gccaatgttg gcatgacaga agaacaaatc atgtctatcc tcttgaccaa ccagtatttg   780
gataccttga atacctttgc ctctaaagga aatcaaacta tctttttacc aaatactcca   840
aatggtgtgg atgatatccg aacacaaatc ttgtcagccc ttcgcgctga gaagaaa      897

<210>   4526
<211>   299
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   SPFH domain/Band 7 family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904003 (e-149)

<400>   4526
Met Ala Ile Phe Phe Met Ile Phe Leu Ile Val Cys Val Leu Leu Leu 
1               5                   10                  15      

Val Ile Val Thr Leu Ser Thr Val Tyr Val Val Arg Gln Gln Ser Val 
            20                  25                  30          

Ala Ile Ile Glu Arg Phe Gly Lys Tyr Gln Lys Val Ala Asn Ser Gly 
        35                  40                  45              

Ile His Ile Arg Leu Pro Phe Gly Ile Asp Ser Ile Ala Ala Arg Ile 

    50                  55                  60                  

Gln Leu Arg Leu Leu Gln Ser Asp Ile Val Val Glu Thr Lys Thr Lys 
65                  70                  75                  80  

Asp Asn Val Phe Val Met Met Asn Val Ala Thr Gln Tyr Arg Val Asn 
                85                  90                  95      

Glu Gln Ser Val Thr Asp Ala Tyr Tyr Lys Leu Ile Arg Pro Glu Ser 
            100                 105                 110         

Gln Ile Lys Ser Tyr Ile Glu Asp Ala Leu Arg Ser Ser Val Pro Lys 
        115                 120                 125             

Leu Thr Leu Asp Glu Leu Phe Glu Lys Lys Asp Glu Ile Ala Leu Glu 
    130                 135                 140                 

Val Gln His Gln Val Ala Glu Glu Met Thr Thr Tyr Gly Tyr Ile Ile 
145                 150                 155                 160 

Val Lys Thr Leu Ile Thr Lys Val Glu Pro Asp Ala Glu Val Lys Gln 
                165                 170                 175     

Ser Met Asn Glu Ile Asn Ala Ala Gln Arg Lys Arg Val Ala Ala Gln 
            180                 185                 190         

Glu Leu Ala Glu Ala Asp Lys Ile Lys Ile Val Thr Ala Ala Glu Ala 
        195                 200                 205             

Glu Ala Glu Lys Asp Arg Leu His Gly Val Gly Ile Ala Gln Gln Arg 
    210                 215                 220                 

Lys Ala Ile Val Asp Gly Leu Ala Glu Ser Ile Thr Glu Leu Lys Glu 
225                 230                 235                 240 

Ala Asn Val Gly Met Thr Glu Glu Gln Ile Met Ser Ile Leu Leu Thr 
                245                 250                 255     

Asn Gln Tyr Leu Asp Thr Leu Asn Thr Phe Ala Ser Lys Gly Asn Gln 
            260                 265                 270         

Thr Ile Phe Leu Pro Asn Thr Pro Asn Gly Val Asp Asp Ile Arg Thr 
        275                 280                 285             

Gln Ile Leu Ser Ala Leu Arg Ala Glu Lys Lys 
    290                 295                 

<210>   4527
<211>   1149
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4527
atggctatat tttatgttcc ggcagtcaac cttattggaa aaggtgttgt aaatgaagtg   60
ggtccttata tcaaggaact tggctataaa aaggcacttt tggtgacaga taagtacatc   120
gaaggcagtg atattttacc taagacttta aaaccactgg atacagaagg aatcgaatat   180
gtcatcttta gcgatgtaga gccaaaccct acttgtaaaa atgtcacaga tggggtagct   240
gctttgcaag aacatggctg tgactttatc atcagtcttg gcgggggttc tccacaggat   300
gcagctagtt gtatttctat catggctaca aatggtggaa aaccacagga ttatgaaggg   360
cttcataagt ctgctaaaaa aggcttgcca gttgtggcta tcaatacaac ggcaggtaca   420
tcagcagaaa ttaccattaa ctatgtgatt actgatgaag aacgcaaggt taagatggta   480
atggttgaca agaatagcct tgctcttatc tctgttaatg accctgaact catgctttcc   540
aaacctaaag gcctgactgc tgctactggt atggatgctc tgactcatgc tgttgaagct   600
ttggtaacac ctggtgctta tgatgtaacc aagaaactgt ctattggtgc tattgagctt   660
atcaaggaat atcttcctcg tgctgtagaa aatggacatg atattgaagc gcgtgaaggt   720
atggtcaatg ccatcttcct tggtggtatg agctttaata atgctggtct tggctatgtt   780
cactcaatgg ctcaccaact cggtgcagta tataatttgc cacatggcgt gtgctgtgcc   840
atgttgctac cagttataga acgtgaaaat gctaaacgtg taccagaagc tttccgcaat   900
gttgccaaag ccttgggact tcatgtagaa ggtaaatcag atcaagaatg tgccgattat   960
gcgattgctg agattgagaa gctttctgag acagtaggta ttcctaagaa actgactgaa   1020
cttggtattg aagaaaaaga tttcgacttt gaataccttt ctaagaatgc cttgattgat   1080
gcctgcgcac caggaaatcc atttatgcca accttagaag aaacgattgc cttttataaa   1140
gagttattt                                                           1149

<210>   4528
<211>   383
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   alcohol dehydrogenase, iron-containing
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904004 (0.E+01)

<400>   4528
Met Ala Ile Phe Tyr Val Pro Ala Val Asn Leu Ile Gly Lys Gly Val 
1               5                   10                  15      

Val Asn Glu Val Gly Pro Tyr Ile Lys Glu Leu Gly Tyr Lys Lys Ala 
            20                  25                  30          

Leu Leu Val Thr Asp Lys Tyr Ile Glu Gly Ser Asp Ile Leu Pro Lys 
        35                  40                  45              

Thr Leu Lys Pro Leu Asp Thr Glu Gly Ile Glu Tyr Val Ile Phe Ser 
    50                  55                  60                  

Asp Val Glu Pro Asn Pro Thr Cys Lys Asn Val Thr Asp Gly Val Ala 
65                  70                  75                  80  

Ala Leu Gln Glu His Gly Cys Asp Phe Ile Ile Ser Leu Gly Gly Gly 
                85                  90                  95      

Ser Pro Gln Asp Ala Ala Ser Cys Ile Ser Ile Met Ala Thr Asn Gly 
            100                 105                 110         

Gly Lys Pro Gln Asp Tyr Glu Gly Leu His Lys Ser Ala Lys Lys Gly 
        115                 120                 125             

Leu Pro Val Val Ala Ile Asn Thr Thr Ala Gly Thr Ser Ala Glu Ile 
    130                 135                 140                 

Thr Ile Asn Tyr Val Ile Thr Asp Glu Glu Arg Lys Val Lys Met Val 
145                 150                 155                 160 

Met Val Asp Lys Asn Ser Leu Ala Leu Ile Ser Val Asn Asp Pro Glu 
                165                 170                 175     

Leu Met Leu Ser Lys Pro Lys Gly Leu Thr Ala Ala Thr Gly Met Asp 
            180                 185                 190         

Ala Leu Thr His Ala Val Glu Ala Leu Val Thr Pro Gly Ala Tyr Asp 
        195                 200                 205             

Val Thr Lys Lys Leu Ser Ile Gly Ala Ile Glu Leu Ile Lys Glu Tyr 
    210                 215                 220                 

Leu Pro Arg Ala Val Glu Asn Gly His Asp Ile Glu Ala Arg Glu Gly 
225                 230                 235                 240 

Met Val Asn Ala Ile Phe Leu Gly Gly Met Ser Phe Asn Asn Ala Gly 
                245                 250                 255     

Leu Gly Tyr Val His Ser Met Ala His Gln Leu Gly Ala Val Tyr Asn 
            260                 265                 270         

Leu Pro His Gly Val Cys Cys Ala Met Leu Leu Pro Val Ile Glu Arg 
        275                 280                 285             

Glu Asn Ala Lys Arg Val Pro Glu Ala Phe Arg Asn Val Ala Lys Ala 
    290                 295                 300                 

Leu Gly Leu His Val Glu Gly Lys Ser Asp Gln Glu Cys Ala Asp Tyr 
305                 310                 315                 320 

Ala Ile Ala Glu Ile Glu Lys Leu Ser Glu Thr Val Gly Ile Pro Lys 
                325                 330                 335     

Lys Leu Thr Glu Leu Gly Ile Glu Glu Lys Asp Phe Asp Phe Glu Tyr 
            340                 345                 350         

Leu Ser Lys Asn Ala Leu Ile Asp Ala Cys Ala Pro Gly Asn Pro Phe 
        355                 360                 365             

Met Pro Thr Leu Glu Glu Thr Ile Ala Phe Tyr Lys Glu Leu Phe 
    370                 375                 380             

<210>   4529
<211>   1764
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4529
atgattcaac atccacgtat tgggattcgt ccgactattg atggtcgtcg tcaaggtgta   60
cgcgaatcac ttgaagtgca aacaatgaac atggctaaaa gtgtggcaga tttgatttca   120
agcacattga aatatccaga tggggaacct gtggaatgcg tgatttctcc atctactatt   180
ggccgtgtac cagaggctgc agcttcccat gagttgttta aaaaatcaaa tgtttgcgca   240
acaattacag ttacaccatg ctggtgttat ggtagtgaaa ctatggatat gtctccagat   300
attcctcatg ctatttgggg atttaatggg acagaacgcc caggagctgt ctatcttgca   360
gctgtactag cttcacatgc tcaaaaaggg attccagcct ttgggattta tggaagagat   420
gttcaggaag ctagtgacac agatattcca gaagatgtca aagaaaaact tttacgctat   480
gcgcgtgcag ctcttgcaac tggcttgatg agagacactg cttacctatc aatgggtagt   540
gtttcgatgg ggattggtgg ttctattgta aatccggatt tcttccaaga atacttagga   600
atgcgaaatg aatcggtaga tatgacggag ttcacgcgcc gtatggaccg tggtatttac   660
gaccctgaag agttcgaacg tgcgctcaaa tgggtgaaag aaaacgtaaa agaaggattc   720
gaccataacc gtgaagacct tgttttaagc cgtgaagaaa aagatagaca atgggaattt   780
gttattaaga tgttcatgat tggacgtgac ttaatggttg gtaacccaag acttgctgaa   840
cttggttttg aggaagaagc ggttggtcac catgctttag tagctggttt ccaaggtcaa   900
cgtcagtgga cagaccattt tccaaatggg gactttatgg aaactttcct caatactcag   960
tttgactgga atggtattcg aaaaccattt gtatttgcga cagagaatga ttcactaaat   1020
ggtgtgtcta tgctctttaa ttatctatta acaaatactc cacaaatctt tgctgatgtg   1080
cgtacttatt ggagcccaga ggctgttaaa cgtgtaacgg gacatacttt agagggtcgt   1140
gctgcagctg gcttcttaca tctaatcaac tctggttctt gtacattgga tggtacaggt   1200
caagctactc gagatggcaa acctattatg aaaccattct gggagttgga agaaagtgaa   1260
gtgcaggcta tgcttgaaaa tacagacttc ccaccagcaa accgcgaata cttccgtgga   1320
ggaggattct caactcgttt cttgacgaag ggggatatgc cagtaacaat ggtacgtctc   1380
aatcttctaa aaggggttgg tccagtgcta caaattgcag aaggttacac acttgaactt   1440
cctgaagatg ttcaccatac tttagataat cgtacagatc caggatggcc aactacttgg   1500
tttgctccac gtttgacagg aaaaggtgct ttcaagtctg tctatgacgt catgaataat   1560
tggggagcta atcacggagc cataacatat ggacacattg gagcagactt gattaccttg   1620
gcttctatgt tgagaattcc tgtcaatatg cataatgtac ctgaggaaga tatctttaga   1680
cctaaaaatt ggtccttatt tggaacagaa gatctagaat cagcagacta tcgtgcatgt   1740
cagttgttgg ggccactaca taaa                                          1764

<210>   4530
<211>   588
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   L-fucose isomerase (fucI)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904005 (0.E+01)

<400>   4530
Met Ile Gln His Pro Arg Ile Gly Ile Arg Pro Thr Ile Asp Gly Arg 
1               5                   10                  15      

Arg Gln Gly Val Arg Glu Ser Leu Glu Val Gln Thr Met Asn Met Ala 
            20                  25                  30          

Lys Ser Val Ala Asp Leu Ile Ser Ser Thr Leu Lys Tyr Pro Asp Gly 
        35                  40                  45              

Glu Pro Val Glu Cys Val Ile Ser Pro Ser Thr Ile Gly Arg Val Pro 
    50                  55                  60                  

Glu Ala Ala Ala Ser His Glu Leu Phe Lys Lys Ser Asn Val Cys Ala 
65                  70                  75                  80  

Thr Ile Thr Val Thr Pro Cys Trp Cys Tyr Gly Ser Glu Thr Met Asp 
                85                  90                  95      

Met Ser Pro Asp Ile Pro His Ala Ile Trp Gly Phe Asn Gly Thr Glu 
            100                 105                 110         

Arg Pro Gly Ala Val Tyr Leu Ala Ala Val Leu Ala Ser His Ala Gln 
        115                 120                 125             

Lys Gly Ile Pro Ala Phe Gly Ile Tyr Gly Arg Asp Val Gln Glu Ala 
    130                 135                 140                 

Ser Asp Thr Asp Ile Pro Glu Asp Val Lys Glu Lys Leu Leu Arg Tyr 
145                 150                 155                 160 

Ala Arg Ala Ala Leu Ala Thr Gly Leu Met Arg Asp Thr Ala Tyr Leu 
                165                 170                 175     

Ser Met Gly Ser Val Ser Met Gly Ile Gly Gly Ser Ile Val Asn Pro 
            180                 185                 190         

Asp Phe Phe Gln Glu Tyr Leu Gly Met Arg Asn Glu Ser Val Asp Met 
        195                 200                 205             

Thr Glu Phe Thr Arg Arg Met Asp Arg Gly Ile Tyr Asp Pro Glu Glu 
    210                 215                 220                 

Phe Glu Arg Ala Leu Lys Trp Val Lys Glu Asn Val Lys Glu Gly Phe 
225                 230                 235                 240 

Asp His Asn Arg Glu Asp Leu Val Leu Ser Arg Glu Glu Lys Asp Arg 
                245                 250                 255     

Gln Trp Glu Phe Val Ile Lys Met Phe Met Ile Gly Arg Asp Leu Met 
            260                 265                 270         

Val Gly Asn Pro Arg Leu Ala Glu Leu Gly Phe Glu Glu Glu Ala Val 
        275                 280                 285             

Gly His His Ala Leu Val Ala Gly Phe Gln Gly Gln Arg Gln Trp Thr 
    290                 295                 300                 

Asp His Phe Pro Asn Gly Asp Phe Met Glu Thr Phe Leu Asn Thr Gln 
305                 310                 315                 320 

Phe Asp Trp Asn Gly Ile Arg Lys Pro Phe Val Phe Ala Thr Glu Asn 
                325                 330                 335     

Asp Ser Leu Asn Gly Val Ser Met Leu Phe Asn Tyr Leu Leu Thr Asn 
            340                 345                 350         

Thr Pro Gln Ile Phe Ala Asp Val Arg Thr Tyr Trp Ser Pro Glu Ala 
        355                 360                 365             

Val Lys Arg Val Thr Gly His Thr Leu Glu Gly Arg Ala Ala Ala Gly 
    370                 375                 380                 

Phe Leu His Leu Ile Asn Ser Gly Ser Cys Thr Leu Asp Gly Thr Gly 
385                 390                 395                 400 

Gln Ala Thr Arg Asp Gly Lys Pro Ile Met Lys Pro Phe Trp Glu Leu 
                405                 410                 415     

Glu Glu Ser Glu Val Gln Ala Met Leu Glu Asn Thr Asp Phe Pro Pro 
            420                 425                 430         

Ala Asn Arg Glu Tyr Phe Arg Gly Gly Gly Phe Ser Thr Arg Phe Leu 
        435                 440                 445             

Thr Lys Gly Asp Met Pro Val Thr Met Val Arg Leu Asn Leu Leu Lys 
    450                 455                 460                 

Gly Val Gly Pro Val Leu Gln Ile Ala Glu Gly Tyr Thr Leu Glu Leu 
465                 470                 475                 480 

Pro Glu Asp Val His His Thr Leu Asp Asn Arg Thr Asp Pro Gly Trp 
                485                 490                 495     

Pro Thr Thr Trp Phe Ala Pro Arg Leu Thr Gly Lys Gly Ala Phe Lys 
            500                 505                 510         

Ser Val Tyr Asp Val Met Asn Asn Trp Gly Ala Asn His Gly Ala Ile 
        515                 520                 525             

Thr Tyr Gly His Ile Gly Ala Asp Leu Ile Thr Leu Ala Ser Met Leu 
    530                 535                 540                 

Arg Ile Pro Val Asn Met His Asn Val Pro Glu Glu Asp Ile Phe Arg 
545                 550                 555                 560 

Pro Lys Asn Trp Ser Leu Phe Gly Thr Glu Asp Leu Glu Ser Ala Asp 
                565                 570                 575     

Tyr Arg Ala Cys Gln Leu Leu Gly Pro Leu His Lys 
            580                 585             

<210>   4531
<211>   3114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4531
atgaataaag aaaaaataaa aagaaaatta atcacaatat tgtttgtatg tattgggatg   60
ttatgttttg gattgttagc aggagttaag gctgataatc gtgttcaaat gagaacgacg   120
attaataatg aatcgccatt gttgctttct ccgttgtatg gcaatgataa tggtaacgga   180
ttatggtggg ggaacacatt gaagggagca tgggaagcta ttcctgaaga tgtaaagcca   240
tatgcagcga ttgaacttca tcctgcaaaa gtctgtaaac caacaagttg tattccacga   300
gatacgaaag aattgagaga atggtatgtc aagatgttgg aggaagctca aagtctaaac   360
attccagttt tcttggttat tatgtcggct ggagagcgta atacagttcc tccagagtgg   420
ttagatgaac aattccaaaa gtatagtgtg ttaaaaggtg ttttaaatat tgagaattat   480
tggatttaca ataaccagtt agctccgcat agtgctaaat atttggaagt ttgtgccaaa   540
tatggagcgc attttatctg gcatgatcat gaaaaatggt tctgggaaac tattatgaat   600
gatccgacat tctttgaagc gagtcaaaaa tatcataaaa atttggtgtt ggcaactaaa   660
aatacgccaa taagagatga tgcgggtaca gattctatcg ttagtggatt ttggttgagt   720
ggcttatgtg ataactgggg ctcatcaaca gatacatgga aatggtggga aaaacattat   780
acaaacacat ttgaaactgg aagagctagg gatatgagat cctatgcatc ggaaccagaa   840
tcaatgattg ctatggaaat gatgaatgta tatactgggg gaggcacagt ttataatttc   900
gaatgtgccg cgtatacatt tatgacaaat gatgtaccaa ctccagcatt tactaaaggt   960
attattcctt tctttagaca tgctatacaa aatccagctc caagtaagga agaagttgta   1020
aatagaacaa aagctgtatt ttggaatgga gaaggtagga ttagttcatt aaacggattt   1080
tatcaaggac tttattcgaa tgatgaaaca atgcctttat ataataatgg gagatatcat   1140
attcttcctg taatacatga gaaaattgat aaggaaaaga tttcatctat attccctaat   1200
gcaaaaattt tgactaaaaa tagtgaggaa ttgtctagta aagtcaacta tttaaactcg   1260
ctttatccaa aactttatga aggagatggg tatgctcagc gtgtaggtaa ttcctggtat   1320
atttataata gtaatgctaa tatcaataaa aatcagcaag taatgttgcc tatgtatact   1380
aataatacaa agtcgttatc gttagatttg acgccacata cttacgctgt tgttaaagaa   1440
aatccaaata atttacatat tttattgaat aattacagga cagataagac agctatgtgg   1500
gcattatcag gaaattttga tgcatcaaaa agttggaaga aagaagaatt agagttagcg   1560
aactggataa gcaaaaatta ttccatcaat cctgtagata atgactttag gacaacaaca   1620
cttacattaa aagggcatac tggtcataaa cctcagataa atataagtgg cgataaaaat   1680
cattatactt atacagaaaa ttgggatgag aatacccatg tttataccat tacggttaat   1740
cataatggaa tggtagagat gtctataaat actgagggga caggtccagt ctctttccca   1800
acaccagata aatttaatga tggtaatttg aatatagcat atgcaaaacc aacaacacaa   1860
agttctgtag attacaatgg agaccctaat agagctgtgg atggtaacag aaatggtaat   1920
tttaactctg gttcggtaac acacactagg gcagataatc cctcttggtg ggaagtcgat   1980
ttgaaaaaaa tggataaagt tgggcttgtt aaaatttata atcgcacaga tgctgagact   2040
caacgtctat ctaattttga tgtgattcta tatgacaata atagaaacga agttgctaag   2100
aaacatgtta ataatttgtc gggtgaatct gttagtctag atttcaaaga aaaaggagca   2160
aggtatatta aagttaaatt actaacgagt ggagtgcctt tgagtttagc agaagtagag   2220
gtttttagag aatcagatgg taagcaatct gaagaggata tagataaaat aacagaagat   2280
aaagtagtct ctacaaataa ggtagctact caaagttcaa ccaattatga gggtgtagct   2340
gctttagcag ttgatggtaa taaagatgga gattacggac atcattcggt gactcatact   2400
aaggcagatt ctaacgcttg gtggcaggtc gatctgggag aagagtttac ggtttctaaa   2460
gttgatattt ataatagaac agatgccgaa cctcagcgtt tatctaattt tgatgttatt   2520
tttctatctt catcaggaga agaagttttt agaagacatt ttgataaagt agttgatggt   2580
ttgttatctt taaaagtacc ttctgtaggg gctaagctag tcaaaataga attaaaatca   2640
gcagctattc cgttaagttt agcggaagtt gaagtctatg gttcaaagag aactccgaag   2700
aaactttcta atattgcatt aacaaaagaa actcgacaga gttcaacgga ttacaatggt   2760
ttttctcgtc tagcagttga tggaaataaa aacggagatt atggtcatca ttcagtgact   2820
cataccaaag aagattctcc ttcatggtgg gagatagatt tagcacaaac cgaagaatta   2880
gaaaagttaa ttatttataa tagaacagat gctgaaattc agagattatc aaattttgat   2940
attattatat atgattcaaa tgattatgaa gtttttacac aacatattga cagtttagaa   3000
agcaataatc tatccataga cttaaaagga ctgaagggaa aaaaggttag aatttctttg   3060
agaagcgcag gaattccttt aagtttagca gaggtagagg tttatactta taag         3114

<210>   4532
<211>   1038
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fucolectin-related protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15904006 (0.E+01)

<400>   4532
Met Asn Lys Glu Lys Ile Lys Arg Lys Leu Ile Thr Ile Leu Phe Val 
1               5                   10                  15      

Cys Ile Gly Met Leu Cys Phe Gly Leu Leu Ala Gly Val Lys Ala Asp 
            20                  25                  30          

Asn Arg Val Gln Met Arg Thr Thr Ile Asn Asn Glu Ser Pro Leu Leu 
        35                  40                  45              

Leu Ser Pro Leu Tyr Gly Asn Asp Asn Gly Asn Gly Leu Trp Trp Gly 
    50                  55                  60                  

Asn Thr Leu Lys Gly Ala Trp Glu Ala Ile Pro Glu Asp Val Lys Pro 
65                  70                  75                  80  

Tyr Ala Ala Ile Glu Leu His Pro Ala Lys Val Cys Lys Pro Thr Ser 
                85                  90                  95      

Cys Ile Pro Arg Asp Thr Lys Glu Leu Arg Glu Trp Tyr Val Lys Met 
            100                 105                 110         

Leu Glu Glu Ala Gln Ser Leu Asn Ile Pro Val Phe Leu Val Ile Met 
        115                 120                 125             

Ser Ala Gly Glu Arg Asn Thr Val Pro Pro Glu Trp Leu Asp Glu Gln 
    130                 135                 140                 

Phe Gln Lys Tyr Ser Val Leu Lys Gly Val Leu Asn Ile Glu Asn Tyr 
145                 150                 155                 160 

Trp Ile Tyr Asn Asn Gln Leu Ala Pro His Ser Ala Lys Tyr Leu Glu 
                165                 170                 175     

Val Cys Ala Lys Tyr Gly Ala His Phe Ile Trp His Asp His Glu Lys 
            180                 185                 190         

Trp Phe Trp Glu Thr Ile Met Asn Asp Pro Thr Phe Phe Glu Ala Ser 
        195                 200                 205             

Gln Lys Tyr His Lys Asn Leu Val Leu Ala Thr Lys Asn Thr Pro Ile 
    210                 215                 220                 

Arg Asp Asp Ala Gly Thr Asp Ser Ile Val Ser Gly Phe Trp Leu Ser 
225                 230                 235                 240 

Gly Leu Cys Asp Asn Trp Gly Ser Ser Thr Asp Thr Trp Lys Trp Trp 
                245                 250                 255     

Glu Lys His Tyr Thr Asn Thr Phe Glu Thr Gly Arg Ala Arg Asp Met 
            260                 265                 270         

Arg Ser Tyr Ala Ser Glu Pro Glu Ser Met Ile Ala Met Glu Met Met 
        275                 280                 285             

Asn Val Tyr Thr Gly Gly Gly Thr Val Tyr Asn Phe Glu Cys Ala Ala 
    290                 295                 300                 

Tyr Thr Phe Met Thr Asn Asp Val Pro Thr Pro Ala Phe Thr Lys Gly 
305                 310                 315                 320 

Ile Ile Pro Phe Phe Arg His Ala Ile Gln Asn Pro Ala Pro Ser Lys 
                325                 330                 335     

Glu Glu Val Val Asn Arg Thr Lys Ala Val Phe Trp Asn Gly Glu Gly 
            340                 345                 350         

Arg Ile Ser Ser Leu Asn Gly Phe Tyr Gln Gly Leu Tyr Ser Asn Asp 
        355                 360                 365             

Glu Thr Met Pro Leu Tyr Asn Asn Gly Arg Tyr His Ile Leu Pro Val 
    370                 375                 380                 

Ile His Glu Lys Ile Asp Lys Glu Lys Ile Ser Ser Ile Phe Pro Asn 
385                 390                 395                 400 

Ala Lys Ile Leu Thr Lys Asn Ser Glu Glu Leu Ser Ser Lys Val Asn 
                405                 410                 415     

Tyr Leu Asn Ser Leu Tyr Pro Lys Leu Tyr Glu Gly Asp Gly Tyr Ala 
            420                 425                 430         

Gln Arg Val Gly Asn Ser Trp Tyr Ile Tyr Asn Ser Asn Ala Asn Ile 
        435                 440                 445             

Asn Lys Asn Gln Gln Val Met Leu Pro Met Tyr Thr Asn Asn Thr Lys 
    450                 455                 460                 

Ser Leu Ser Leu Asp Leu Thr Pro His Thr Tyr Ala Val Val Lys Glu 
465                 470                 475                 480 

Asn Pro Asn Asn Leu His Ile Leu Leu Asn Asn Tyr Arg Thr Asp Lys 
                485                 490                 495     

Thr Ala Met Trp Ala Leu Ser Gly Asn Phe Asp Ala Ser Lys Ser Trp 
            500                 505                 510         

Lys Lys Glu Glu Leu Glu Leu Ala Asn Trp Ile Ser Lys Asn Tyr Ser 
        515                 520                 525             

Ile Asn Pro Val Asp Asn Asp Phe Arg Thr Thr Thr Leu Thr Leu Lys 
    530                 535                 540                 

Gly His Thr Gly His Lys Pro Gln Ile Asn Ile Ser Gly Asp Lys Asn 
545                 550                 555                 560 

His Tyr Thr Tyr Thr Glu Asn Trp Asp Glu Asn Thr His Val Tyr Thr 
                565                 570                 575     

Ile Thr Val Asn His Asn Gly Met Val Glu Met Ser Ile Asn Thr Glu 
            580                 585                 590         

Gly Thr Gly Pro Val Ser Phe Pro Thr Pro Asp Lys Phe Asn Asp Gly 
        595                 600                 605             

Asn Leu Asn Ile Ala Tyr Ala Lys Pro Thr Thr Gln Ser Ser Val Asp 
    610                 615                 620                 

Tyr Asn Gly Asp Pro Asn Arg Ala Val Asp Gly Asn Arg Asn Gly Asn 
625                 630                 635                 640 

Phe Asn Ser Gly Ser Val Thr His Thr Arg Ala Asp Asn Pro Ser Trp 
                645                 650                 655     

Trp Glu Val Asp Leu Lys Lys Met Asp Lys Val Gly Leu Val Lys Ile 
            660                 665                 670         

Tyr Asn Arg Thr Asp Ala Glu Thr Gln Arg Leu Ser Asn Phe Asp Val 
        675                 680                 685             

Ile Leu Tyr Asp Asn Asn Arg Asn Glu Val Ala Lys Lys His Val Asn 
    690                 695                 700                 

Asn Leu Ser Gly Glu Ser Val Ser Leu Asp Phe Lys Glu Lys Gly Ala 
705                 710                 715                 720 

Arg Tyr Ile Lys Val Lys Leu Leu Thr Ser Gly Val Pro Leu Ser Leu 
                725                 730                 735     

Ala Glu Val Glu Val Phe Arg Glu Ser Asp Gly Lys Gln Ser Glu Glu 
            740                 745                 750         

Asp Ile Asp Lys Ile Thr Glu Asp Lys Val Val Ser Thr Asn Lys Val 
        755                 760                 765             

Ala Thr Gln Ser Ser Thr Asn Tyr Glu Gly Val Ala Ala Leu Ala Val 
    770                 775                 780                 

Asp Gly Asn Lys Asp Gly Asp Tyr Gly His His Ser Val Thr His Thr 
785                 790                 795                 800 

Lys Ala Asp Ser Asn Ala Trp Trp Gln Val Asp Leu Gly Glu Glu Phe 
                805                 810                 815     

Thr Val Ser Lys Val Asp Ile Tyr Asn Arg Thr Asp Ala Glu Pro Gln 
            820                 825                 830         

Arg Leu Ser Asn Phe Asp Val Ile Phe Leu Ser Ser Ser Gly Glu Glu 
        835                 840                 845             

Val Phe Arg Arg His Phe Asp Lys Val Val Asp Gly Leu Leu Ser Leu 
    850                 855                 860                 

Lys Val Pro Ser Val Gly Ala Lys Leu Val Lys Ile Glu Leu Lys Ser 
865                 870                 875                 880 

Ala Ala Ile Pro Leu Ser Leu Ala Glu Val Glu Val Tyr Gly Ser Lys 
                885                 890                 895     

Arg Thr Pro Lys Lys Leu Ser Asn Ile Ala Leu Thr Lys Glu Thr Arg 
            900                 905                 910         

Gln Ser Ser Thr Asp Tyr Asn Gly Phe Ser Arg Leu Ala Val Asp Gly 
        915                 920                 925             

Asn Lys Asn Gly Asp Tyr Gly His His Ser Val Thr His Thr Lys Glu 
    930                 935                 940                 

Asp Ser Pro Ser Trp Trp Glu Ile Asp Leu Ala Gln Thr Glu Glu Leu 
945                 950                 955                 960 

Glu Lys Leu Ile Ile Tyr Asn Arg Thr Asp Ala Glu Ile Gln Arg Leu 
                965                 970                 975     

Ser Asn Phe Asp Ile Ile Ile Tyr Asp Ser Asn Asp Tyr Glu Val Phe 
            980                 985                 990         

Thr Gln His Ile Asp Ser Leu Glu Ser Asn Asn Leu Ser Ile Asp Leu 
        995                 1000                1005            

Lys Gly Leu Lys Gly Lys Lys Val Arg Ile Ser Leu Arg Ser Ala Gly 
    1010                1015                1020                

Ile Pro Leu Ser Leu Ala Glu Val Glu Val Tyr Thr Tyr Lys 
1025                1030                1035            

<210>   4533
<211>   2292
<212>   DNA
<213>   Streptococcus pneumoniae


<400>   4533
gtgaaattat ggtataagaa agctgccgca aattggaatg aagccttgcc gattgggaac   60
ggtcatttag gtggtatgat ttatggttca gctacaaaag aatgtattca actaaacgat   120
gagactattt ggtatagagg aaagtcagat agaaataatc cagactcact attgcatctt   180
aaaaaaattc gggaatatct tttagatgga gaaattcaga aagccgaaga attgataaag   240
ttaacagtgt ttgctacccc aagagatcaa agccactatg aattacttgg ggaactttac   300
attgagcata tagatattca gtcttgtgct ctttcattgt atgaaagaga gctagattta   360
gatacagcta tttctaatgt tgtgtttgag cctaatagtt gtaatttaca aataaaaaga   420
gaatatttta cgagttttaa taagaatatt ttatgttgcc gtatagtgtc atcagttcaa   480
aacacattaa atttaaacat taatttgggt agaaataaac ggtttaatga cgaagtatct   540
aaactggatt caagtacaat tttaatgtcg gcctctgctg gaggtagaaa aggtgttcag   600
tttaaagtag tatgtcattc taaggttacg gatggtgaag taagtgtatt gggagagaca   660
atagttattc ggaatgctac agaggtattt ctttatctca aatcaatgac ggattattgg   720
ggaaatatag atatttcttc tcttcaggga gaatttagta gtattgatta ctttacagaa   780
aaagatgaac atgtaaaaaa atatcaggag caatttaata gagttgattt taaactagac   840
tatagtaaag gttgtcttag cattccaacg aatctacttc ttgaaaacac taaaaagtat   900
agtaactact tgactaactt gttatttcat tatggaagat atctgttaat atcgtctagt   960
caaccgaatg gtttacctgc caatcttcaa ggaatatggt gtgatgaatt aaatccaatt   1020
tggggttcta aatatacgat taatattaat actcaaatga attattggat ggtaggtcca   1080
tgtgatttac cagaagtaga atatccatta tttgatatgc tcgaaagaat gagagaaccg   1140
ggaagactaa ccgctaagaa aatgtatgga gctagaggtt ttacagcaca tcataatacg   1200
gatggttttg gcgatacggc tccccaatct catgccatgg gggctgcaat ttgggtatta   1260
actattccat ggttatgtac tcatatttgg gaacactatt tatatttcca agatgagcgt   1320
attcttacgg aacattttga aatgataaaa gaagcatttc ttttctttga agattattta   1380
tttgaggtgg atggctactt gatgacaggt ccaagtgtct caccggaaaa taaatatcgc   1440
ttaaaaaatg gtattgaagg aaatgcttgt ctatcatcta caattgataa tcaaattcta   1500
agatattttt gtgattcatg cattggcatt gcaaaacaat taggagacaa ttcggatttt   1560
attagtcgtg tgaaggagtt aaaaaagaaa ctacctaaaa caaaaatagg tagtaatggg   1620
caaatccaag aatggttaga agattatgaa gaagtagagc ctgggcatag acacatttca   1680
cctctatttg ggctttatcc ttataatgag attgatattc ataaaactcc ggaattagca   1740
gaagcagcta aaatcactat caataggaga ttatcaaacg ctaatttttt atcttcacag   1800
gagagggagc aagcgattaa taattggtta gtaagtggtt tgcatgctag tacacaaaca   1860
ggttggagtg ctgcatggct gattcatttt tttgcgagac tatatcaagg tgaacctgct   1920
tataaccaga ttaatggttt gttaaataat gcgactcttg gcaatttatt tcttgaccat   1980
ccaccatttc aaattgatgg taatttaggt ttggtgagtg gaatttgtga attattagta   2040
cagagccatc ataattggtt atcactaatt ccagctttac cttctgcttg gtcagaagga   2100
gaagtgaaag gtttcagagt aagaggagga tataaggtat cgtttgcttg gaaaaatggg   2160
gatataacat tcctaaaatt ggaaggagga aacaaagatc aaaaagtaag agtaagaata   2220
tatggcaaaa atactgatgt acaaaatatt gaattggtat ttaattcaga aaaaattatt   2280
gagttaaatt tt                                                       2292

<210>   4534
<211>   764
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904007 (0.E+01)

<400>   4534
Met Lys Leu Trp Tyr Lys Lys Ala Ala Ala Asn Trp Asn Glu Ala Leu 
1               5                   10                  15      

Pro Ile Gly Asn Gly His Leu Gly Gly Met Ile Tyr Gly Ser Ala Thr 
            20                  25                  30          

Lys Glu Cys Ile Gln Leu Asn Asp Glu Thr Ile Trp Tyr Arg Gly Lys 
        35                  40                  45              

Ser Asp Arg Asn Asn Pro Asp Ser Leu Leu His Leu Lys Lys Ile Arg 
    50                  55                  60                  

Glu Tyr Leu Leu Asp Gly Glu Ile Gln Lys Ala Glu Glu Leu Ile Lys 
65                  70                  75                  80  

Leu Thr Val Phe Ala Thr Pro Arg Asp Gln Ser His Tyr Glu Leu Leu 
                85                  90                  95      

Gly Glu Leu Tyr Ile Glu His Ile Asp Ile Gln Ser Cys Ala Leu Ser 
            100                 105                 110         

Leu Tyr Glu Arg Glu Leu Asp Leu Asp Thr Ala Ile Ser Asn Val Val 
        115                 120                 125             


Phe Glu Pro Asn Ser Cys Asn Leu Gln Ile Lys Arg Glu Tyr Phe Thr 
    130                 135                 140                 

Ser Phe Asn Lys Asn Ile Leu Cys Cys Arg Ile Val Ser Ser Val Gln 
145                 150                 155                 160 

Asn Thr Leu Asn Leu Asn Ile Asn Leu Gly Arg Asn Lys Arg Phe Asn 
                165                 170                 175     

Asp Glu Val Ser Lys Leu Asp Ser Ser Thr Ile Leu Met Ser Ala Ser 
            180                 185                 190         

Ala Gly Gly Arg Lys Gly Val Gln Phe Lys Val Val Cys His Ser Lys 
        195                 200                 205             

Val Thr Asp Gly Glu Val Ser Val Leu Gly Glu Thr Ile Val Ile Arg 
    210                 215                 220                 

Asn Ala Thr Glu Val Phe Leu Tyr Leu Lys Ser Met Thr Asp Tyr Trp 
225                 230                 235                 240 

Gly Asn Ile Asp Ile Ser Ser Leu Gln Gly Glu Phe Ser Ser Ile Asp 
                245                 250                 255     

Tyr Phe Thr Glu Lys Asp Glu His Val Lys Lys Tyr Gln Glu Gln Phe 
            260                 265                 270         

Asn Arg Val Asp Phe Lys Leu Asp Tyr Ser Lys Gly Cys Leu Ser Ile 
        275                 280                 285             

Pro Thr Asn Leu Leu Leu Glu Asn Thr Lys Lys Tyr Ser Asn Tyr Leu 
    290                 295                 300                 

Thr Asn Leu Leu Phe His Tyr Gly Arg Tyr Leu Leu Ile Ser Ser Ser 
305                 310                 315                 320 

Gln Pro Asn Gly Leu Pro Ala Asn Leu Gln Gly Ile Trp Cys Asp Glu 
                325                 330                 335     

Leu Asn Pro Ile Trp Gly Ser Lys Tyr Thr Ile Asn Ile Asn Thr Gln 
            340                 345                 350         

Met Asn Tyr Trp Met Val Gly Pro Cys Asp Leu Pro Glu Val Glu Tyr 
        355                 360                 365             

Pro Leu Phe Asp Met Leu Glu Arg Met Arg Glu Pro Gly Arg Leu Thr 
    370                 375                 380                 

Ala Lys Lys Met Tyr Gly Ala Arg Gly Phe Thr Ala His His Asn Thr 
385                 390                 395                 400 

Asp Gly Phe Gly Asp Thr Ala Pro Gln Ser His Ala Met Gly Ala Ala 
                405                 410                 415     

Ile Trp Val Leu Thr Ile Pro Trp Leu Cys Thr His Ile Trp Glu His 
            420                 425                 430         

Tyr Leu Tyr Phe Gln Asp Glu Arg Ile Leu Thr Glu His Phe Glu Met 
        435                 440                 445             

Ile Lys Glu Ala Phe Leu Phe Phe Glu Asp Tyr Leu Phe Glu Val Asp 
    450                 455                 460                 

Gly Tyr Leu Met Thr Gly Pro Ser Val Ser Pro Glu Asn Lys Tyr Arg 
465                 470                 475                 480 

Leu Lys Asn Gly Ile Glu Gly Asn Ala Cys Leu Ser Ser Thr Ile Asp 
                485                 490                 495     

Asn Gln Ile Leu Arg Tyr Phe Cys Asp Ser Cys Ile Gly Ile Ala Lys 
            500                 505                 510         

Gln Leu Gly Asp Asn Ser Asp Phe Ile Ser Arg Val Lys Glu Leu Lys 
        515                 520                 525             

Lys Lys Leu Pro Lys Thr Lys Ile Gly Ser Asn Gly Gln Ile Gln Glu 
    530                 535                 540                 

Trp Leu Glu Asp Tyr Glu Glu Val Glu Pro Gly His Arg His Ile Ser 
545                 550                 555                 560 

Pro Leu Phe Gly Leu Tyr Pro Tyr Asn Glu Ile Asp Ile His Lys Thr 
                565                 570                 575     

Pro Glu Leu Ala Glu Ala Ala Lys Ile Thr Ile Asn Arg Arg Leu Ser 
            580                 585                 590         

Asn Ala Asn Phe Leu Ser Ser Gln Glu Arg Glu Gln Ala Ile Asn Asn 
        595                 600                 605             

Trp Leu Val Ser Gly Leu His Ala Ser Thr Gln Thr Gly Trp Ser Ala 
    610                 615                 620                 

Ala Trp Leu Ile His Phe Phe Ala Arg Leu Tyr Gln Gly Glu Pro Ala 
625                 630                 635                 640 

Tyr Asn Gln Ile Asn Gly Leu Leu Asn Asn Ala Thr Leu Gly Asn Leu 
                645                 650                 655     

Phe Leu Asp His Pro Pro Phe Gln Ile Asp Gly Asn Leu Gly Leu Val 
            660                 665                 670         

Ser Gly Ile Cys Glu Leu Leu Val Gln Ser His His Asn Trp Leu Ser 
        675                 680                 685             

Leu Ile Pro Ala Leu Pro Ser Ala Trp Ser Glu Gly Glu Val Lys Gly 
    690                 695                 700                 

Phe Arg Val Arg Gly Gly Tyr Lys Val Ser Phe Ala Trp Lys Asn Gly 
705                 710                 715                 720 

Asp Ile Thr Phe Leu Lys Leu Glu Gly Gly Asn Lys Asp Gln Lys Val 
                725                 730                 735     

Arg Val Arg Ile Tyr Gly Lys Asn Thr Asp Val Gln Asn Ile Glu Leu 
            740                 745                 750         

Val Phe Asn Ser Glu Lys Ile Ile Glu Leu Asn Phe 
        755                 760                 

<210>   4535
<211>   798
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4535
atgatgaata ataaagtaac taaagttgaa cttaaaaaag ttttcaaacg aagttttatg   60
tatggttctt catggaacta tgagagaatg cagaacctag gttttctata tacaattctt   120
ccagtattga aaaaactata cccagacaaa gattcagctt ctcctgcaat gaaacgtcac   180
cttgagtttt tcaatactca tcaaacagcg gcaccattta ttcttggagt tacttccgct   240
atggaagaac aagaaggaaa tgaaggtgca gcttcaatta ctggtattaa agttggcttg   300
atggggccac tggctggtct aggagatagt ttgttctggc tgacactagt tcctatctgt   360
tttagtattg gtgcgtctta ttctaaagac ggcggtgctt taggtatctt tatcgcctta   420
atattgttta atattattaa tattcctgtt aaatatttcg gtttgaaata tgggtatact   480
aagggttcta gtcttatcca agaaaataat acaaaaggaa cattgaatcg cgttacgagt   540
atggcgacag cattagggct agtactagtg ggtggtttga ttccatcaat ggttggtatt   600
aattttggat tagaatttaa gcagggggaa cttgttattt ctgttcaaga aatgattaca   660
aaattaattc caggatttat ccctatggct ttgactttat taatgtgtaa attaattaga   720
aaaggaaaga atccggttgt actaatcttt agtgttatgg ctattggagt tattctagtt   780
gttttaggaa ttttgaag                                                 798

<210>   4536
<211>   266
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IID component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904008 (e-150)

<400>   4536
Met Met Asn Asn Lys Val Thr Lys Val Glu Leu Lys Lys Val Phe Lys 
1               5                   10                  15      

Arg Ser Phe Met Tyr Gly Ser Ser Trp Asn Tyr Glu Arg Met Gln Asn 
            20                  25                  30          

Leu Gly Phe Leu Tyr Thr Ile Leu Pro Val Leu Lys Lys Leu Tyr Pro 
        35                  40                  45              

Asp Lys Asp Ser Ala Ser Pro Ala Met Lys Arg His Leu Glu Phe Phe 
    50                  55                  60                  

Asn Thr His Gln Thr Ala Ala Pro Phe Ile Leu Gly Val Thr Ser Ala 
65                  70                  75                  80  

Met Glu Glu Gln Glu Gly Asn Glu Gly Ala Ala Ser Ile Thr Gly Ile 
                85                  90                  95      

Lys Val Gly Leu Met Gly Pro Leu Ala Gly Leu Gly Asp Ser Leu Phe 
            100                 105                 110         

Trp Leu Thr Leu Val Pro Ile Cys Phe Ser Ile Gly Ala Ser Tyr Ser 
        115                 120                 125             

Lys Asp Gly Gly Ala Leu Gly Ile Phe Ile Ala Leu Ile Leu Phe Asn 
    130                 135                 140                 

Ile Ile Asn Ile Pro Val Lys Tyr Phe Gly Leu Lys Tyr Gly Tyr Thr 
145                 150                 155                 160 

Lys Gly Ser Ser Leu Ile Gln Glu Asn Asn Thr Lys Gly Thr Leu Asn 
                165                 170                 175     

Arg Val Thr Ser Met Ala Thr Ala Leu Gly Leu Val Leu Val Gly Gly 
            180                 185                 190         

Leu Ile Pro Ser Met Val Gly Ile Asn Phe Gly Leu Glu Phe Lys Gln 
        195                 200                 205             

Gly Glu Leu Val Ile Ser Val Gln Glu Met Ile Thr Lys Leu Ile Pro 
    210                 215                 220                 

Gly Phe Ile Pro Met Ala Leu Thr Leu Leu Met Cys Lys Leu Ile Arg 
225                 230                 235                 240 

Lys Gly Lys Asn Pro Val Val Leu Ile Phe Ser Val Met Ala Ile Gly 
                245                 250                 255     

Val Ile Leu Val Val Leu Gly Ile Leu Lys 
            260                 265     

<210>   4537
<211>   771
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4537
atgctattca cacaagcatt actggtgaca ttagttggga ttattgccac tattgactat   60
aatggaccgt tatttatgat tcaccgtccg ttagttacaa gtgcaatggt tggcttagta   120
ttaggagatt tcacccaagg tgttcttatt ggttcagctc ttgaattaac ttggctcggt   180
gtaacaggta ttggaggtta tactccacca gatactattt caggtgcgat tattggtact   240
gcatttggta ttttatctgg tcaaggagaa actgctggta tcgctatagc agttccaatt   300
gcagttgcta cccaacagtt ggatgttctt gcaaaaactt tagatgttta ttttgtgaaa   360
aaagctgata atgatgctaa aaacggagat tattcaaaga tcggttttta tcattattca   420
agtttggttt taatcacgtt atttaaaatt gtaccaattt tcctagctat tatgcttgga   480
ggggaatatg tggcagactt gtttgctaag gttccaccaa tcgttatgca gggacttaac   540
tctgcaggtg ctttactacc ttcaattggt tttggtatgc ttttaaatat gatgctcaag   600
aaaaatatgt gggtattctt gttgattgga ttcatttgtt ctgtgtatgg aggaatgtca   660
accattggga tctcactagt tggtattgcg gtagcatact tctacgatat gattggaagc   720
aaaccacaag aaacaacttc aagtagtgat gttgaggagg atcttgatct a            771

<210>   4538
<211>   257
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIC component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904009 (e-144)

<400>   4538
Met Leu Phe Thr Gln Ala Leu Leu Val Thr Leu Val Gly Ile Ile Ala 
1               5                   10                  15      

Thr Ile Asp Tyr Asn Gly Pro Leu Phe Met Ile His Arg Pro Leu Val 
            20                  25                  30          

Thr Ser Ala Met Val Gly Leu Val Leu Gly Asp Phe Thr Gln Gly Val 
        35                  40                  45              

Leu Ile Gly Ser Ala Leu Glu Leu Thr Trp Leu Gly Val Thr Gly Ile 
    50                  55                  60                  

Gly Gly Tyr Thr Pro Pro Asp Thr Ile Ser Gly Ala Ile Ile Gly Thr 
65                  70                  75                  80  

Ala Phe Gly Ile Leu Ser Gly Gln Gly Glu Thr Ala Gly Ile Ala Ile 
                85                  90                  95      

Ala Val Pro Ile Ala Val Ala Thr Gln Gln Leu Asp Val Leu Ala Lys 
            100                 105                 110         

Thr Leu Asp Val Tyr Phe Val Lys Lys Ala Asp Asn Asp Ala Lys Asn 
        115                 120                 125             

Gly Asp Tyr Ser Lys Ile Gly Phe Tyr His Tyr Ser Ser Leu Val Leu 
    130                 135                 140                 

Ile Thr Leu Phe Lys Ile Val Pro Ile Phe Leu Ala Ile Met Leu Gly 
145                 150                 155                 160 

Gly Glu Tyr Val Ala Asp Leu Phe Ala Lys Val Pro Pro Ile Val Met 
                165                 170                 175     

Gln Gly Leu Asn Ser Ala Gly Ala Leu Leu Pro Ser Ile Gly Phe Gly 
            180                 185                 190         

Met Leu Leu Asn Met Met Leu Lys Lys Asn Met Trp Val Phe Leu Leu 
        195                 200                 205             

Ile Gly Phe Ile Cys Ser Val Tyr Gly Gly Met Ser Thr Ile Gly Ile 
    210                 215                 220                 

Ser Leu Val Gly Ile Ala Val Ala Tyr Phe Tyr Asp Met Ile Gly Ser 
225                 230                 235                 240 

Lys Pro Gln Glu Thr Thr Ser Ser Ser Asp Val Glu Glu Asp Leu Asp 
                245                 250                 255     

Leu 
    

<210>   4539
<211>   468
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4539
atgtctatag agtttgttcg tattgatgac cgtctggtac atggtcaagt tgtcactacg   60
tggctaaaaa agtatgatat tgagcaagtt atcattgtta atgatcgcat ctcagaagat   120
aaaacacgac aatctatttt aaagatttct gcaccggtag gtttaaaaat tgttttcttt   180
agtgtaaaac ggtttgtgga agttttaaac tctgtgccaa taaaaaagag aacaatgctg   240
atatatacaa atccaaaaga tgtgtatgat tctattgaag gaaatttaaa attggagtac   300
ctcaatgtag gacagatgag taaaacggag gaaaatgaaa aggtaacggg aggtgtagct   360
ctaggtgaag aagacaaata ttattttaag aaaatagttg ataagggaac gagagttgaa   420
attcaaatgg ttcctaatga taaagttaca atgttggaaa aattttta                468

<210>   4540
<211>   156
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIB component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904010 (1.E-84)

<400>   4540
Met Ser Ile Glu Phe Val Arg Ile Asp Asp Arg Leu Val His Gly Gln 
1               5                   10                  15      

Val Val Thr Thr Trp Leu Lys Lys Tyr Asp Ile Glu Gln Val Ile Ile 
            20                  25                  30          

Val Asn Asp Arg Ile Ser Glu Asp Lys Thr Arg Gln Ser Ile Leu Lys 
        35                  40                  45              

Ile Ser Ala Pro Val Gly Leu Lys Ile Val Phe Phe Ser Val Lys Arg 
    50                  55                  60                  

Phe Val Glu Val Leu Asn Ser Val Pro Ile Lys Lys Arg Thr Met Leu 
65                  70                  75                  80  

Ile Tyr Thr Asn Pro Lys Asp Val Tyr Asp Ser Ile Glu Gly Asn Leu 
                85                  90                  95      

Lys Leu Glu Tyr Leu Asn Val Gly Gln Met Ser Lys Thr Glu Glu Asn 
            100                 105                 110         

Glu Lys Val Thr Gly Gly Val Ala Leu Gly Glu Glu Asp Lys Tyr Tyr 
        115                 120                 125             

Phe Lys Lys Ile Val Asp Lys Gly Thr Arg Val Glu Ile Gln Met Val 
    130                 135                 140                 

Pro Asn Asp Lys Val Thr Met Leu Glu Lys Phe Leu 
145                 150                 155     

<210>   4541
<211>   444
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4541
ttgttgaaag agaaaatgtt caatagagga attttagttg ccagtcatgg taattttgct   60
agcggagctc tcatgaccgc agaaatgttt gttggtgaga caacaaatga tagagttagg   120
acattaggtt tgatgcctgg agagaatatt gtagagtttg agcattattt taaaaatcaa   180
gtggatgaac tgttagactc aaatcaagag gttatcgttt tgactgactt gattggagga   240
agtcctaata atgtggcttt gtcacggttt ttaaatttgg attcagttga tattgtaaca   300
gggtttaata tccctctcct agtggaatta atatcaagtt atgattcaaa aatcaattta   360
gaagaaattg ttcacaatgc tcaaaatagt ttgtttaatg ttaaacaaca acttaacgta   420
gaggaggaag aagatttatg tcta                                          444

<210>   4542
<211>   148
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIA component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904011 (3.E-77)

<400>   4542
Met Leu Lys Glu Lys Met Phe Asn Arg Gly Ile Leu Val Ala Ser His 
1               5                   10                  15      

Gly Asn Phe Ala Ser Gly Ala Leu Met Thr Ala Glu Met Phe Val Gly 
            20                  25                  30          

Glu Thr Thr Asn Asp Arg Val Arg Thr Leu Gly Leu Met Pro Gly Glu 
        35                  40                  45              

Asn Ile Val Glu Phe Glu His Tyr Phe Lys Asn Gln Val Asp Glu Leu 
    50                  55                  60                  

Leu Asp Ser Asn Gln Glu Val Ile Val Leu Thr Asp Leu Ile Gly Gly 
65                  70                  75                  80  

Ser Pro Asn Asn Val Ala Leu Ser Arg Phe Leu Asn Leu Asp Ser Val 
                85                  90                  95      

Asp Ile Val Thr Gly Phe Asn Ile Pro Leu Leu Val Glu Leu Ile Ser 
            100                 105                 110         

Ser Tyr Asp Ser Lys Ile Asn Leu Glu Glu Ile Val His Asn Ala Gln 
        115                 120                 125             

Asn Ser Leu Phe Asn Val Lys Gln Gln Leu Asn Val Glu Glu Glu Glu 
    130                 135                 140                 

Asp Leu Cys Leu 
145             

<210>   4543
<211>   441
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4543
atgttaaaac atataccgaa aaatatttct ccagatttat tgaagacttt aatggaaatg   60
ggacatggag atgaaatagt attagctgac gcgaattatc cttctgcctc atgtgcaaat   120
aagctaattc gttgtgatgg tgtaaatatt ccagaattat tagattccat tctgtattta   180
atgccattag atagttacgt cgatagttca attcagttta tgaacgttgt ttcgggtgat   240
gatattccta agatatgggg tacctataga cagatgattg aaggtcatgg tacagatctt   300
aaaacgatta cttatcttag aagagaagac ttttatgaac gtagtaagaa agcttatgct   360
attgttgcta caggagaaac ttcactttat gctaatatta tccttaagaa aggagtagtt   420
gttgaaagag aaaatgttca a                                             441

<210>   4544
<211>   147
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fucose operon FucU protein (fucU)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904012 (1.E-81)

<400>   4544
Met Leu Lys His Ile Pro Lys Asn Ile Ser Pro Asp Leu Leu Lys Thr 
1               5                   10                  15      

Leu Met Glu Met Gly His Gly Asp Glu Ile Val Leu Ala Asp Ala Asn 
            20                  25                  30          

Tyr Pro Ser Ala Ser Cys Ala Asn Lys Leu Ile Arg Cys Asp Gly Val 
        35                  40                  45              

Asn Ile Pro Glu Leu Leu Asp Ser Ile Leu Tyr Leu Met Pro Leu Asp 
    50                  55                  60                  

Ser Tyr Val Asp Ser Ser Ile Gln Phe Met Asn Val Val Ser Gly Asp 
65                  70                  75                  80  

Asp Ile Pro Lys Ile Trp Gly Thr Tyr Arg Gln Met Ile Glu Gly His 
                85                  90                  95      

Gly Thr Asp Leu Lys Thr Ile Thr Tyr Leu Arg Arg Glu Asp Phe Tyr 
            100                 105                 110         

Glu Arg Ser Lys Lys Ala Tyr Ala Ile Val Ala Thr Gly Glu Thr Ser 
        115                 120                 125             

Leu Tyr Ala Asn Ile Ile Leu Lys Lys Gly Val Val Val Glu Arg Glu 
    130                 135                 140                 

Asn Val Gln 
145         

<210>   4545
<211>   636
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4545
atgtcagatg taaaacaaga attaattaaa tatggtaaga agctagtaga aacagatttg   60
acgaaaggaa caggtgggaa tctcagcgtt ttcgatcgtg aaaaacaatt gatggcaatt   120
accccgtcgg gtattgattt ctttgaaatc aaagaatccg atattgtagt gatggatatt   180
aatggaaatg ttgtagaggg agaacgcttg ccatctagcg aatggtatat gcatttgatt   240
caatatcaaa ctcgtgatga tatcgatgca attatccatg ctcatacaac ttatgcaaca   300
gtattagctt gtctcagaga accacttcca gcgagtcatt atatgattgc agtggcaggg   360
aaagatgttc gggtagctga gtatgcaaca tatggcacga aagaattggc tgtgaatgca   420
gctaaagcaa tggaaggtcg tagagcagtt ttactagcga atcatggaat tttagcaggt   480
gcacaaaatt tattgaatgc atttaatatt gttgaagaag ttgaatattg tgcaaaaatt   540
tattgtttag ctaagaattt tggagagcca gtagttcttc ctgatgagga gatggaattg   600
atggcagaaa aatttaaaac atacggtcag agaaaa                             636

<210>   4546
<211>   212
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   L-fuculose phosphate aldolase (fucA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904013 (e-120)

<400>   4546
Met Ser Asp Val Lys Gln Glu Leu Ile Lys Tyr Gly Lys Lys Leu Val 
1               5                   10                  15      

Glu Thr Asp Leu Thr Lys Gly Thr Gly Gly Asn Leu Ser Val Phe Asp 
            20                  25                  30          

Arg Glu Lys Gln Leu Met Ala Ile Thr Pro Ser Gly Ile Asp Phe Phe 
        35                  40                  45              

Glu Ile Lys Glu Ser Asp Ile Val Val Met Asp Ile Asn Gly Asn Val 
    50                  55                  60                  

Val Glu Gly Glu Arg Leu Pro Ser Ser Glu Trp Tyr Met His Leu Ile 
65                  70                  75                  80  

Gln Tyr Gln Thr Arg Asp Asp Ile Asp Ala Ile Ile His Ala His Thr 
                85                  90                  95      

Thr Tyr Ala Thr Val Leu Ala Cys Leu Arg Glu Pro Leu Pro Ala Ser 
            100                 105                 110         

His Tyr Met Ile Ala Val Ala Gly Lys Asp Val Arg Val Ala Glu Tyr 
        115                 120                 125             

Ala Thr Tyr Gly Thr Lys Glu Leu Ala Val Asn Ala Ala Lys Ala Met 
    130                 135                 140                 

Glu Gly Arg Arg Ala Val Leu Leu Ala Asn His Gly Ile Leu Ala Gly 
145                 150                 155                 160 

Ala Gln Asn Leu Leu Asn Ala Phe Asn Ile Val Glu Glu Val Glu Tyr 
                165                 170                 175     

Cys Ala Lys Ile Tyr Cys Leu Ala Lys Asn Phe Gly Glu Pro Val Val 
            180                 185                 190         

Leu Pro Asp Glu Glu Met Glu Leu Met Ala Glu Lys Phe Lys Thr Tyr 
        195                 200                 205             

Gly Gln Arg Lys 
    210         

<210>   4547
<211>   1401
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4547
atggaagcgg ttttagcaat agatttaggt gcgacttctg gaagagcaat cgttggttac   60
ctttctgaaa ataaactagt aatggaagaa ataaatcgct tttctaatct acctattaga   120
gtaaaagggc atttatcttg ggatattgac tttctactag ctaaaattct tgaaagtatc   180
cgcttggcta atactagtta caagatttta tctatcggta ttgacacatg gggagttgat   240
tttggactga ttgataatga aggtaagctg ttattacaac ctgttcatta tcgtgatgaa   300
agaacaaagg gagtgttaaa ggaaatatct gaaatgactg aattagaaaa actgtattca   360
gagacaggaa atcagattat ggagataaat accttgtttc aactctttaa ggcacgtcaa   420
gaatctcctg actctttcta taagaccaat aagattcttt taatgccaga tttgtttaat   480
tatctcttga caggtaagtt tgctacagaa aaaagcattg cttcaacaac tcaattattt   540
gatcctagga gtcaaaattg gaatcagaat atcttaaaac tatttgaatt ggattcatct   600
ttacttcctg aaattgtttc agagggaaat gttcttggaa ggataaaaga ggagtatggt   660
ttaggcgata ttcctgttgt gaatgtttgt agtcatgata cagcaagcgc gattgtctca   720
gtacctaaga cagaaggtag tttatttatt tcatcaggta cttggtcttt ggttggagtg   780
gaacttactt caccgattct tactaccgaa tccttcagtt atggatttac aaatgaagtc   840
ggtaaagatg gagtgattac atttctgaag aattgtacag ggttgtggat catagaggaa   900
ctaagacgtt catttgaacg aagagggaaa gcctattctt ttgatgatat taggacaatg   960
gtggagaaag aaaaagaaaa tcttcctctg attgatactg aatcaactga atttgcaaca   1020
gaatctgata tgcacaagac tttgacagaa tatctagctt atcatcatga aactagagag   1080
tggacagatg gacaactatt taagattgtt tatgaaagcc tagctgaaac gtataggaaa   1140
gcgatagagt tactagaaga actaactcat aaggtttata agaggatata tgtgattgga   1200
ggaggtgcta gagccagtta ctttaaccaa atgattgctg atagaactgg taaagaggtt   1260
cttacaggtt tgactgaggc tacagctgtg gggaatattg ttgtgcagct catagctatg   1320
ggacaattaa aagggatgga agaggctcac catgttattg aggagtttct acaattagag   1380
agttattact cccaaaagaa t                                             1401

<210>   4548
<211>   467
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   L-fuculose kinase fucK, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904014 (0.E+01)

<400>   4548
Met Glu Ala Val Leu Ala Ile Asp Leu Gly Ala Thr Ser Gly Arg Ala 
1               5                   10                  15      

Ile Val Gly Tyr Leu Ser Glu Asn Lys Leu Val Met Glu Glu Ile Asn 
            20                  25                  30          

Arg Phe Ser Asn Leu Pro Ile Arg Val Lys Gly His Leu Ser Trp Asp 
        35                  40                  45              

Ile Asp Phe Leu Leu Ala Lys Ile Leu Glu Ser Ile Arg Leu Ala Asn 
    50                  55                  60                  

Thr Ser Tyr Lys Ile Leu Ser Ile Gly Ile Asp Thr Trp Gly Val Asp 
65                  70                  75                  80  

Phe Gly Leu Ile Asp Asn Glu Gly Lys Leu Leu Leu Gln Pro Val His 
                85                  90                  95      

Tyr Arg Asp Glu Arg Thr Lys Gly Val Leu Lys Glu Ile Ser Glu Met 
            100                 105                 110         

Thr Glu Leu Glu Lys Leu Tyr Ser Glu Thr Gly Asn Gln Ile Met Glu 
        115                 120                 125             

Ile Asn Thr Leu Phe Gln Leu Phe Lys Ala Arg Gln Glu Ser Pro Asp 
    130                 135                 140                 

Ser Phe Tyr Lys Thr Asn Lys Ile Leu Leu Met Pro Asp Leu Phe Asn 
145                 150                 155                 160 

Tyr Leu Leu Thr Gly Lys Phe Ala Thr Glu Lys Ser Ile Ala Ser Thr 
                165                 170                 175     

Thr Gln Leu Phe Asp Pro Arg Ser Gln Asn Trp Asn Gln Asn Ile Leu 
            180                 185                 190         

Lys Leu Phe Glu Leu Asp Ser Ser Leu Leu Pro Glu Ile Val Ser Glu 
        195                 200                 205             

Gly Asn Val Leu Gly Arg Ile Lys Glu Glu Tyr Gly Leu Gly Asp Ile 
    210                 215                 220                 

Pro Val Val Asn Val Cys Ser His Asp Thr Ala Ser Ala Ile Val Ser 
225                 230                 235                 240 

Val Pro Lys Thr Glu Gly Ser Leu Phe Ile Ser Ser Gly Thr Trp Ser 
                245                 250                 255     

Leu Val Gly Val Glu Leu Thr Ser Pro Ile Leu Thr Thr Glu Ser Phe 
            260                 265                 270         

Ser Tyr Gly Phe Thr Asn Glu Val Gly Lys Asp Gly Val Ile Thr Phe 
        275                 280                 285             

Leu Lys Asn Cys Thr Gly Leu Trp Ile Ile Glu Glu Leu Arg Arg Ser 
    290                 295                 300                 

Phe Glu Arg Arg Gly Lys Ala Tyr Ser Phe Asp Asp Ile Arg Thr Met 
305                 310                 315                 320 

Val Glu Lys Glu Lys Glu Asn Leu Pro Leu Ile Asp Thr Glu Ser Thr 
                325                 330                 335     

Glu Phe Ala Thr Glu Ser Asp Met His Lys Thr Leu Thr Glu Tyr Leu 
            340                 345                 350         

Ala Tyr His His Glu Thr Arg Glu Trp Thr Asp Gly Gln Leu Phe Lys 
        355                 360                 365             

Ile Val Tyr Glu Ser Leu Ala Glu Thr Tyr Arg Lys Ala Ile Glu Leu 
    370                 375                 380                 

Leu Glu Glu Leu Thr His Lys Val Tyr Lys Arg Ile Tyr Val Ile Gly 
385                 390                 395                 400 

Gly Gly Ala Arg Ala Ser Tyr Phe Asn Gln Met Ile Ala Asp Arg Thr 
                405                 410                 415     

Gly Lys Glu Val Leu Thr Gly Leu Thr Glu Ala Thr Ala Val Gly Asn 
            420                 425                 430         

Ile Val Val Gln Leu Ile Ala Met Gly Gln Leu Lys Gly Met Glu Glu 
        435                 440                 445             

Ala His His Val Ile Glu Glu Phe Leu Gln Leu Glu Ser Tyr Tyr Ser 
    450                 455                 460                 

Gln Lys Asn 
465         

<210>   4549
<211>   771
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4549
atgataaaag atgaacgtgt acttgaattg attgaaatta tcaaaaagaa aaaaagaatt   60
gccgtaaaag agctggcaga aatcactttc tccagcacaa gtaccttacg tcgtgattta   120
attttcttag aaaatcaagg tcttatcaaa agaaagcacg gatacgtgac cctgtcctct   180
atgaacacaa ttgaactttc tcatcaaata cgtgaaggag aaagtactag gcaaaaaaga   240
ctaatcgcta gtctcgctaa agactttatt cggtctggta tgtgtatcta tctagattct   300
agtactactg tctacgaact ctgtccctat ctttctgaac ttgataattt gattattttt   360
acaaatggtt tacatactgc acaaacccta tctgaaactg ttaaagatag ctccaaaatc   420
tttatcacat ctggcgaggt caaacatcaa tcctgttccg tggtcaacta tgataaggaa   480
aattctttat tagatcattt taatatcgat ttagcatttt gttcagcaag aggtattgat   540
gaccaatatg tttatgaagc ttctctcagc caagctattt caaaaaagaa tattattgac   600
aaagcccatg aaaccatctt actgattgat agttctaaat tttacaagac tggatttttt   660
aaaattaatc ccctctccaa atacacaacc tttatttcag acaccgtgcc agatcaaaaa   720
ttattagacg cagtcgaatt atttgatgga gaatgggttt ctgatattca a            771

<210>   4550
<211>   257
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fucose operon repressor, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904015 (e-143)

<400>   4550
Met Ile Lys Asp Glu Arg Val Leu Glu Leu Ile Glu Ile Ile Lys Lys 
1               5                   10                  15      

Lys Lys Arg Ile Ala Val Lys Glu Leu Ala Glu Ile Thr Phe Ser Ser 
            20                  25                  30          

Thr Ser Thr Leu Arg Arg Asp Leu Ile Phe Leu Glu Asn Gln Gly Leu 
        35                  40                  45              


Ile Lys Arg Lys His Gly Tyr Val Thr Leu Ser Ser Met Asn Thr Ile 
    50                  55                  60                  

Glu Leu Ser His Gln Ile Arg Glu Gly Glu Ser Thr Arg Gln Lys Arg 
65                  70                  75                  80  

Leu Ile Ala Ser Leu Ala Lys Asp Phe Ile Arg Ser Gly Met Cys Ile 
                85                  90                  95      

Tyr Leu Asp Ser Ser Thr Thr Val Tyr Glu Leu Cys Pro Tyr Leu Ser 
            100                 105                 110         

Glu Leu Asp Asn Leu Ile Ile Phe Thr Asn Gly Leu His Thr Ala Gln 
        115                 120                 125             

Thr Leu Ser Glu Thr Val Lys Asp Ser Ser Lys Ile Phe Ile Thr Ser 
    130                 135                 140                 

Gly Glu Val Lys His Gln Ser Cys Ser Val Val Asn Tyr Asp Lys Glu 
145                 150                 155                 160 

Asn Ser Leu Leu Asp His Phe Asn Ile Asp Leu Ala Phe Cys Ser Ala 
                165                 170                 175     

Arg Gly Ile Asp Asp Gln Tyr Val Tyr Glu Ala Ser Leu Ser Gln Ala 
            180                 185                 190         

Ile Ser Lys Lys Asn Ile Ile Asp Lys Ala His Glu Thr Ile Leu Leu 
        195                 200                 205             

Ile Asp Ser Ser Lys Phe Tyr Lys Thr Gly Phe Phe Lys Ile Asn Pro 
    210                 215                 220                 

Leu Ser Lys Tyr Thr Thr Phe Ile Ser Asp Thr Val Pro Asp Gln Lys 
225                 230                 235                 240 

Leu Leu Asp Ala Val Glu Leu Phe Asp Gly Glu Trp Val Ser Asp Ile 
                245                 250                 255     

Gln 
    

<210>   4551
<211>   1503
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4551
gtgaaaaaaa ttagcttatt actagccagt ctatgtgcct tgtttttagt ggcttgttcc   60
aatcaaaaac aggcagatgg taaactcaat atcgtgacaa ccttttaccc tgtctatgaa   120
tttaccaagc aagtcgcagg agatacggct aatgtagaac tcctaatcgg tgctgggaca   180
gaacctcatg aatacgaacc atctgccaag gcagttgcca aaatccaaga tgcagatacc   240
ttcgtttatg aaaatgaaaa catggaaaca tgggtaccta aattgctaga taccttggat   300
aagaaaaaag tgaaaaccat caaggcgaca ggcgatatgt tgctcttgcc aggtggcgag   360
gaagaagagg gagaccatga ccatggagaa gaaggtcatc accatgagtt tgacccccat   420
gtttggttat caccagttcg tgccattaaa ctagtagagc acatccgcga cagcttgtca   480
gcagattatc ctgataaaaa agagaccttt gagaagaatg cagctgccta tatcgaaaaa   540
ttgcaagcct tggataaggc ttacgcagaa ggtttgtctc aagcaaaaca aaagagcttt   600
gtgactcaac acgcagcctt taactatctt gccttggact atggactcaa acaagtcgca   660
atctcaggac tttctccaga tgcagagcca tcagctgctc gcttggcaga attgacagag   720
tatgtcaaga aaaataaaat cgcctatatc tattttgaag aaaatgcctc acaagccctt   780
gctaacacac tttcaaaaga agcaggtgtc aaaactgatg tcctcaatcc tttagaaagt   840
ctgacagaag aggacaccaa ggctggagaa aactacattt ccgtgatgga gaaaaacctc   900
aaggctttga aacaaacaac agaccaagaa ggcccagcaa ttgaacctga aaaggcagag   960
gataccaaga cagtccaaaa tggttacttc gaggatgcag ctgtcaagga ccgcaccttg   1020
agtgactatg caggtaactg gcaatcagtt tatcctttcc ttgaagacgg cacgtttgac   1080
caagtctttg actacaaggc taagttgact ggtaagatga cccaggctga gtacaaggct   1140
tactatacaa aaggctatca tacagatgtg actaagatta acattactga taatactatg   1200
gaatttgttc aaggtggaca aagcaagaaa tacacttaca agtatgtcgg taagaaaatt   1260
ttgacttaca agaaaggcaa tcgtggcgtg cgtttcctct ttgaagccac agatgctgac   1320
gctggacaat tcaagtatgt tcagtttagt gaccacaatg ttgccccagt taaggcagaa   1380
catttccata tcttctttgg aggcacaagc caagaagccc tctttgaaga aatggacaac   1440
tggccaacct actacccaga taacctatct ggccaagaaa tcgcccaaga aatgttggcg   1500
cat                                                                 1503

<210>   4552
<211>   501
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   zinc ABC transporter, zinc-binding adhesion liprotein (adcA)
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15904016 (0.E+01)

<400>   4552
Met Lys Lys Ile Ser Leu Leu Leu Ala Ser Leu Cys Ala Leu Phe Leu 
1               5                   10                  15      

Val Ala Cys Ser Asn Gln Lys Gln Ala Asp Gly Lys Leu Asn Ile Val 
            20                  25                  30          

Thr Thr Phe Tyr Pro Val Tyr Glu Phe Thr Lys Gln Val Ala Gly Asp 
        35                  40                  45              

Thr Ala Asn Val Glu Leu Leu Ile Gly Ala Gly Thr Glu Pro His Glu 
    50                  55                  60                  

Tyr Glu Pro Ser Ala Lys Ala Val Ala Lys Ile Gln Asp Ala Asp Thr 
65                  70                  75                  80  

Phe Val Tyr Glu Asn Glu Asn Met Glu Thr Trp Val Pro Lys Leu Leu 
                85                  90                  95      

Asp Thr Leu Asp Lys Lys Lys Val Lys Thr Ile Lys Ala Thr Gly Asp 
            100                 105                 110         

Met Leu Leu Leu Pro Gly Gly Glu Glu Glu Glu Gly Asp His Asp His 
        115                 120                 125             

Gly Glu Glu Gly His His His Glu Phe Asp Pro His Val Trp Leu Ser 
    130                 135                 140                 

Pro Val Arg Ala Ile Lys Leu Val Glu His Ile Arg Asp Ser Leu Ser 
145                 150                 155                 160 

Ala Asp Tyr Pro Asp Lys Lys Glu Thr Phe Glu Lys Asn Ala Ala Ala 
                165                 170                 175     

Tyr Ile Glu Lys Leu Gln Ala Leu Asp Lys Ala Tyr Ala Glu Gly Leu 
            180                 185                 190         

Ser Gln Ala Lys Gln Lys Ser Phe Val Thr Gln His Ala Ala Phe Asn 
        195                 200                 205             

Tyr Leu Ala Leu Asp Tyr Gly Leu Lys Gln Val Ala Ile Ser Gly Leu 
    210                 215                 220                 

Ser Pro Asp Ala Glu Pro Ser Ala Ala Arg Leu Ala Glu Leu Thr Glu 
225                 230                 235                 240 

Tyr Val Lys Lys Asn Lys Ile Ala Tyr Ile Tyr Phe Glu Glu Asn Ala 
                245                 250                 255     

Ser Gln Ala Leu Ala Asn Thr Leu Ser Lys Glu Ala Gly Val Lys Thr 
            260                 265                 270         

Asp Val Leu Asn Pro Leu Glu Ser Leu Thr Glu Glu Asp Thr Lys Ala 
        275                 280                 285             

Gly Glu Asn Tyr Ile Ser Val Met Glu Lys Asn Leu Lys Ala Leu Lys 
    290                 295                 300                 

Gln Thr Thr Asp Gln Glu Gly Pro Ala Ile Glu Pro Glu Lys Ala Glu 
305                 310                 315                 320 

Asp Thr Lys Thr Val Gln Asn Gly Tyr Phe Glu Asp Ala Ala Val Lys 
                325                 330                 335     

Asp Arg Thr Leu Ser Asp Tyr Ala Gly Asn Trp Gln Ser Val Tyr Pro 
            340                 345                 350         

Phe Leu Glu Asp Gly Thr Phe Asp Gln Val Phe Asp Tyr Lys Ala Lys 
        355                 360                 365             

Leu Thr Gly Lys Met Thr Gln Ala Glu Tyr Lys Ala Tyr Tyr Thr Lys 
    370                 375                 380                 

Gly Tyr His Thr Asp Val Thr Lys Ile Asn Ile Thr Asp Asn Thr Met 
385                 390                 395                 400 

Glu Phe Val Gln Gly Gly Gln Ser Lys Lys Tyr Thr Tyr Lys Tyr Val 
                405                 410                 415     

Gly Lys Lys Ile Leu Thr Tyr Lys Lys Gly Asn Arg Gly Val Arg Phe 
            420                 425                 430         

Leu Phe Glu Ala Thr Asp Ala Asp Ala Gly Gln Phe Lys Tyr Val Gln 
        435                 440                 445             

Phe Ser Asp His Asn Val Ala Pro Val Lys Ala Glu His Phe His Ile 
    450                 455                 460                 

Phe Phe Gly Gly Thr Ser Gln Glu Ala Leu Phe Glu Glu Met Asp Asn 
465                 470                 475                 480 

Trp Pro Thr Tyr Tyr Pro Asp Asn Leu Ser Gly Gln Glu Ile Ala Gln 
                485                 490                 495     

Glu Met Leu Ala His 
            500     

<210>   4553
<211>   804
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4553
atgcttagtt tattatctta cgactttata caacgcgcct ttttggcggt tattgctatg   60
agtcttttct caccggtatt gggaaccttc ctcatcttgc gtcgtcagag tttgatgagt   120
gataccctta gccacgtctc actttcaggt gtagcctttg gtctggtttt ggggatttct   180
ccaactgttt ctactattgc cattgtcttg attgcggcgg tctttctgga gtatctccgt   240
acggtttaca agagctttat ggaaatcggg acagctatcc tcatgtcaac aggtctggct   300
gtttctctga ttgtcatgag caagggtaaa agctcgagtt caatgagttt ggaccaatat   360
ctctttggtt cgatcgtgac tatcagtgaa gaacaggtca tttccctctt tgtcattgcg   420
gcggttgttt tgattttgac ctttctcttt cttcgtccta tgtatatctt aacttttgac   480
gaagatacgg cctttgtgga tggcttgcca gttcgtacca tgtccattct ttttaacatg   540
gtgacagggg tggctattgc ccttatgatt cctgcagcag gagctcttct ggtatcgacc   600
attatggtct tgccagctag tattgccctg cgtctgggga aaaactttaa atcggttatg   660
ctgcttgcca gtgcgattgg ctttttggga atggtagcag gactttacat ttcctactat   720
gcagaaacac ctgcaagtgc aagtattacc attatttttg taactgtctt tatactaatc   780
agtttagtaa gacgttttat caaa                                          804

<210>   4554
<211>   268
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   zinc ABC transporter, permease protein (adcB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904017 (e-140)

<400>   4554
Met Leu Ser Leu Leu Ser Tyr Asp Phe Ile Gln Arg Ala Phe Leu Ala 
1               5                   10                  15      

Val Ile Ala Met Ser Leu Phe Ser Pro Val Leu Gly Thr Phe Leu Ile 
            20                  25                  30          

Leu Arg Arg Gln Ser Leu Met Ser Asp Thr Leu Ser His Val Ser Leu 
        35                  40                  45              

Ser Gly Val Ala Phe Gly Leu Val Leu Gly Ile Ser Pro Thr Val Ser 
    50                  55                  60                  

Thr Ile Ala Ile Val Leu Ile Ala Ala Val Phe Leu Glu Tyr Leu Arg 
65                  70                  75                  80  

Thr Val Tyr Lys Ser Phe Met Glu Ile Gly Thr Ala Ile Leu Met Ser 
                85                  90                  95      

Thr Gly Leu Ala Val Ser Leu Ile Val Met Ser Lys Gly Lys Ser Ser 
            100                 105                 110         

Ser Ser Met Ser Leu Asp Gln Tyr Leu Phe Gly Ser Ile Val Thr Ile 
        115                 120                 125             

Ser Glu Glu Gln Val Ile Ser Leu Phe Val Ile Ala Ala Val Val Leu 
    130                 135                 140                 

Ile Leu Thr Phe Leu Phe Leu Arg Pro Met Tyr Ile Leu Thr Phe Asp 
145                 150                 155                 160 

Glu Asp Thr Ala Phe Val Asp Gly Leu Pro Val Arg Thr Met Ser Ile 
                165                 170                 175     

Leu Phe Asn Met Val Thr Gly Val Ala Ile Ala Leu Met Ile Pro Ala 
            180                 185                 190         

Ala Gly Ala Leu Leu Val Ser Thr Ile Met Val Leu Pro Ala Ser Ile 
        195                 200                 205             

Ala Leu Arg Leu Gly Lys Asn Phe Lys Ser Val Met Leu Leu Ala Ser 
    210                 215                 220                 

Ala Ile Gly Phe Leu Gly Met Val Ala Gly Leu Tyr Ile Ser Tyr Tyr 
225                 230                 235                 240 

Ala Glu Thr Pro Ala Ser Ala Ser Ile Thr Ile Ile Phe Val Thr Val 
                245                 250                 255     

Phe Ile Leu Ile Ser Leu Val Arg Arg Phe Ile Lys 
            260                 265             

<210>   4555
<211>   702
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4555
atgagatata ttacggtaga ggatttgtcc ttctattatg ataaggagcc tgttcttgaa   60
catatcaatt attgtgttga tagtggggaa tttgttacct tgactgggga aaatggagcg   120
gctaagacga cgctcatcaa ggctagtctt ggaattctgc aaccacgcat tggaaaggtg   180
gctatttcaa agacaaatac gcaaggtaag aaattgagaa tagcctatct tcctcaacaa   240
attgccagtt ttaatgctgg ttttccaagt acggtctatg aatttgtcaa gtcgggtcgc   300
tatccgagaa aaggctggtt ccgtcgtttg aatgctcatg atgaggagca tatcaaggct   360
agtctggact cagttggcat gtgggaacat cgagacaaac gcttggggtc tctatctggg   420
ggacaaaagc agcgagcggt aattgcgcgt atgtttgctt ctgaccctga tgtgtttatc   480
ctagacgagc cgacaacggg gatggatgca ggaagtaaaa atgaatttta cgaactcatg   540
caccacagcg cccatcatca tggcaaggct gttttgatga ttacccatga ccctgaagaa   600
gttaaggatt atgcggatcg caatattcat ctagtccgta accaagactc gccatggcgt   660
tgtttcaatg ttcatgagaa tggccaggag gtgggccatg ct                      702

<210>   4556
<211>   234
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   zinc ABC transporter, ATP-binding protein (adcC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904018 (e-138)

<400>   4556
Met Arg Tyr Ile Thr Val Glu Asp Leu Ser Phe Tyr Tyr Asp Lys Glu 
1               5                   10                  15      

Pro Val Leu Glu His Ile Asn Tyr Cys Val Asp Ser Gly Glu Phe Val 
            20                  25                  30          

Thr Leu Thr Gly Glu Asn Gly Ala Ala Lys Thr Thr Leu Ile Lys Ala 
        35                  40                  45              

Ser Leu Gly Ile Leu Gln Pro Arg Ile Gly Lys Val Ala Ile Ser Lys 
    50                  55                  60                  

Thr Asn Thr Gln Gly Lys Lys Leu Arg Ile Ala Tyr Leu Pro Gln Gln 
65                  70                  75                  80  

Ile Ala Ser Phe Asn Ala Gly Phe Pro Ser Thr Val Tyr Glu Phe Val 
                85                  90                  95      

Lys Ser Gly Arg Tyr Pro Arg Lys Gly Trp Phe Arg Arg Leu Asn Ala 
            100                 105                 110         

His Asp Glu Glu His Ile Lys Ala Ser Leu Asp Ser Val Gly Met Trp 
        115                 120                 125             

Glu His Arg Asp Lys Arg Leu Gly Ser Leu Ser Gly Gly Gln Lys Gln 
    130                 135                 140                 

Arg Ala Val Ile Ala Arg Met Phe Ala Ser Asp Pro Asp Val Phe Ile 
145                 150                 155                 160 

Leu Asp Glu Pro Thr Thr Gly Met Asp Ala Gly Ser Lys Asn Glu Phe 
                165                 170                 175     

Tyr Glu Leu Met His His Ser Ala His His His Gly Lys Ala Val Leu 
            180                 185                 190         

Met Ile Thr His Asp Pro Glu Glu Val Lys Asp Tyr Ala Asp Arg Asn 
        195                 200                 205             

Ile His Leu Val Arg Asn Gln Asp Ser Pro Trp Arg Cys Phe Asn Val 
    210                 215                 220                 

His Glu Asn Gly Gln Glu Val Gly His Ala 
225                 230                 

<210>   4557
<211>   498
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4557
atgtcaaaga atagtatttt tctcttaaaa aagagaagtc taaaaggaaa ggagtcagat   60
atgagacagc tagcaaagga tatcaatgct tttttgaatg aggtgatttt gcaggcggaa   120
aatcagcatg aaatcctaat aggtcattgc actagcgagg tggccctgac caatactcag   180
gagcatatcc ttatgctctt gtcagaggaa tctttaacaa attcagaatt ggcccgtcgt   240
ctcaatgtca gtcaggcggc agttaccaag gccattaagt ctttggtcaa ggaagggatg   300
ttggaaacat ctaaagattc taaagatgcg cgtgtgattt tttatcagtt gactgacttg   360
gctcgtccaa tcgctgagga gcaccaccat caccatgagc atacactttt aacctatgaa   420
caagtggcga ctcagtttac tccaaatgaa caaaaagtga ttcagcggtt tttgactgct   480
ttagtaggag aaatcaaa                                                 498

<210>   4558
<211>   166
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   adc operon repressor AdcR (adcR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904019 (8.E-79)

<400>   4558
Met Ser Lys Asn Ser Ile Phe Leu Leu Lys Lys Arg Ser Leu Lys Gly 
1               5                   10                  15      

Lys Glu Ser Asp Met Arg Gln Leu Ala Lys Asp Ile Asn Ala Phe Leu 
            20                  25                  30          

Asn Glu Val Ile Leu Gln Ala Glu Asn Gln His Glu Ile Leu Ile Gly 
        35                  40                  45              

His Cys Thr Ser Glu Val Ala Leu Thr Asn Thr Gln Glu His Ile Leu 
    50                  55                  60                  

Met Leu Leu Ser Glu Glu Ser Leu Thr Asn Ser Glu Leu Ala Arg Arg 
65                  70                  75                  80  

Leu Asn Val Ser Gln Ala Ala Val Thr Lys Ala Ile Lys Ser Leu Val 
                85                  90                  95      

Lys Glu Gly Met Leu Glu Thr Ser Lys Asp Ser Lys Asp Ala Arg Val 
            100                 105                 110         

Ile Phe Tyr Gln Leu Thr Asp Leu Ala Arg Pro Ile Ala Glu Glu His 
        115                 120                 125             

His His His His Glu His Thr Leu Leu Thr Tyr Glu Gln Val Ala Thr 
    130                 135                 140                 

Gln Phe Thr Pro Asn Glu Gln Lys Val Ile Gln Arg Phe Leu Thr Ala 
145                 150                 155                 160 

Leu Val Gly Glu Ile Lys 
                165     

<210>   4559
<211>   1248
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4559
atgatcttcg gaccggtctt gatcgctggt ttgttggttt ttctgctcat tttcttttat   60
cctactgaga tgcatcataa tctaggagct gaaaagcgtt cagcagtggc tactactatc   120
gatagtttta aggagcgaag tcaaaaagtc agagcactat ctgatccaaa tgtgcgtttt   180
gttcccttct ttggctctag tgaatggctt cgttttgacg gtgctcatcc tgcggtatta   240
gctgagaaat acaatcgttc ctaccgtcct tatcttttag gacagggggg agctgcatcg   300
cttaaccaat attttggaat gcaacagatg ttaccacagc tggagaataa acaagttgtg   360
tatgttatct cacctcagtg gttcagtaaa aatggctatg atccagcagc cttccagcag   420
tattttaatg gagaccagtt gactagtttt ctgaaacatc aatctgggga tcaggctagt   480
caatatgcag cgactcgctt actgcaacag ttcccaaacg tagctatgaa ggacctggtt   540
cagaagttgg caagtaaaga agaattgtcg acagcagaca atgaaatgat tgaattattg   600
gctcgtttta atgaacgcca agcttccttt tttggtcagt tttcggttag aggctatgtt   660
aactacgata agcatgtagc taagtattta aaaatcttgc cagaccagtt ttcttatcag   720
gcaatagaag atgttgtcaa agcagatgct gaaaaaaata cttccaataa tgagatggga   780
atggaaaatt atttctataa tgagcagatc aagaaggatt tgaagaaatt aaaggattct   840
cagaaaagct ttacctatct caagtcgcca gagtataatg acttgcagtt ggttttaaca   900
cagttttcta aatctaaggt aaacccgatt tttatcattc cacctgttaa taaaaaatgg   960
atgaactatg ctggtctacg agaggatatg taccaacaaa cggtgcagaa gattcgctac   1020
cagttagaaa gtcaaggttt taccaatata gcagattttt ctaaggacgg cggggagcct   1080
ttctttatga aggacaccat tcaccttggt tggttgggtt ggttggcttt tgacaaggca   1140
gttgatcctt tcctatccaa tcccacacca gctccgactt accatctgaa tgagcgcttt   1200
ttcagcaaag attgggcgac ttatgatgga gatgtcaaag aatttcaa                1248

<210>   4560
<211>   416
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dltD protein (dltD)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15904020 (0.E+01)

<400>   4560
Met Ile Phe Gly Pro Val Leu Ile Ala Gly Leu Leu Val Phe Leu Leu 
1               5                   10                  15      

Ile Phe Phe Tyr Pro Thr Glu Met His His Asn Leu Gly Ala Glu Lys 
            20                  25                  30          

Arg Ser Ala Val Ala Thr Thr Ile Asp Ser Phe Lys Glu Arg Ser Gln 
        35                  40                  45              

Lys Val Arg Ala Leu Ser Asp Pro Asn Val Arg Phe Val Pro Phe Phe 
    50                  55                  60                  

Gly Ser Ser Glu Trp Leu Arg Phe Asp Gly Ala His Pro Ala Val Leu 
65                  70                  75                  80  

Ala Glu Lys Tyr Asn Arg Ser Tyr Arg Pro Tyr Leu Leu Gly Gln Gly 
                85                  90                  95      

Gly Ala Ala Ser Leu Asn Gln Tyr Phe Gly Met Gln Gln Met Leu Pro 
            100                 105                 110         

Gln Leu Glu Asn Lys Gln Val Val Tyr Val Ile Ser Pro Gln Trp Phe 
        115                 120                 125             

Ser Lys Asn Gly Tyr Asp Pro Ala Ala Phe Gln Gln Tyr Phe Asn Gly 
    130                 135                 140                 

Asp Gln Leu Thr Ser Phe Leu Lys His Gln Ser Gly Asp Gln Ala Ser 
145                 150                 155                 160 

Gln Tyr Ala Ala Thr Arg Leu Leu Gln Gln Phe Pro Asn Val Ala Met 
                165                 170                 175     

Lys Asp Leu Val Gln Lys Leu Ala Ser Lys Glu Glu Leu Ser Thr Ala 
            180                 185                 190         

Asp Asn Glu Met Ile Glu Leu Leu Ala Arg Phe Asn Glu Arg Gln Ala 
        195                 200                 205             

Ser Phe Phe Gly Gln Phe Ser Val Arg Gly Tyr Val Asn Tyr Asp Lys 
    210                 215                 220                 

His Val Ala Lys Tyr Leu Lys Ile Leu Pro Asp Gln Phe Ser Tyr Gln 
225                 230                 235                 240 

Ala Ile Glu Asp Val Val Lys Ala Asp Ala Glu Lys Asn Thr Ser Asn 
                245                 250                 255     

Asn Glu Met Gly Met Glu Asn Tyr Phe Tyr Asn Glu Gln Ile Lys Lys 
            260                 265                 270         

Asp Leu Lys Lys Leu Lys Asp Ser Gln Lys Ser Phe Thr Tyr Leu Lys 
        275                 280                 285             

Ser Pro Glu Tyr Asn Asp Leu Gln Leu Val Leu Thr Gln Phe Ser Lys 
    290                 295                 300                 

Ser Lys Val Asn Pro Ile Phe Ile Ile Pro Pro Val Asn Lys Lys Trp 
305                 310                 315                 320 

Met Asn Tyr Ala Gly Leu Arg Glu Asp Met Tyr Gln Gln Thr Val Gln 
                325                 330                 335     

Lys Ile Arg Tyr Gln Leu Glu Ser Gln Gly Phe Thr Asn Ile Ala Asp 
            340                 345                 350         

Phe Ser Lys Asp Gly Gly Glu Pro Phe Phe Met Lys Asp Thr Ile His 
        355                 360                 365             

Leu Gly Trp Leu Gly Trp Leu Ala Phe Asp Lys Ala Val Asp Pro Phe 
    370                 375                 380                 

Leu Ser Asn Pro Thr Pro Ala Pro Thr Tyr His Leu Asn Glu Arg Phe 
385                 390                 395                 400 

Phe Ser Lys Asp Trp Ala Thr Tyr Asp Gly Asp Val Lys Glu Phe Gln 
                405                 410                 415     


<210>   4561
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4561
atggatatca aatcagaagt tattgaaatt attgatgagt tgtttatgga agatgtttct   60
gacatgatgg atgaagatct ttttgatgca ggtgtcttgg atagtatggg aacggttgag   120
ttgattgtgg agattgagaa ccgttttgac attcgtgtcc ctgtaacaga gtttggtcgt   180
gacgactgga atacagctaa taaaatcata gctggtattg tggagctaca aaatgct      237

<210>   4562
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   D-alanyl carrier protein (dltC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904021 (1.E-40)

<400>   4562
Met Asp Ile Lys Ser Glu Val Ile Glu Ile Ile Asp Glu Leu Phe Met 
1               5                   10                  15      

Glu Asp Val Ser Asp Met Met Asp Glu Asp Leu Phe Asp Ala Gly Val 
            20                  25                  30          

Leu Asp Ser Met Gly Thr Val Glu Leu Ile Val Glu Ile Glu Asn Arg 
        35                  40                  45              

Phe Asp Ile Arg Val Pro Val Thr Glu Phe Gly Arg Asp Asp Trp Asn 
    50                  55                  60                  

Thr Ala Asn Lys Ile Ile Ala Gly Ile Val Glu Leu Gln Asn Ala 
65                  70                  75                  

<210>   4563
<211>   1242
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4563
atgatggagt tttttcaaca gcttcctcat ttagagccat atggcaatcc tcagtatttt   60
gtttatgtga ttgctgcaac cttgcccatc tttataggtc tctttttcaa gaaacgcttt   120
gcctggtatg aagtgttggt aagtctcttc tttattgtca ccatgttggt gggtggaaag   180
accaatcaac tagctgcctt gggtatttac ctttgctggg aaatattgct cctgcttttc   240
tacaagcatt atcgaaaaag caaggatggc aagtgggtct tctacttagt tagttttctg   300
tccctacttc cgattatctt tgtcaaggtg caaccagcta tcaatggaac gcagtctttg   360
cttgggttct tgggaatttc ttacctgacc tttcgttcgg ttggaattgt catcgagctg   420
agagatggag tgattaagga ttttaccctc tgggaattcc tccgtttcct tctcttcatg   480
ccaactttct cgagtggtcc aatcgatcgc tttaagcgat ttaatgaaaa ttatcaggct   540
attcctgagc gagatgagtt gatggatatg ctggatgaat ctgtccgcta tatcatgtgg   600
ggctttttgt ataagtttat cctagctcat gttttaggag agaccttact acctcctctg   660
aagaatttag ccttgcagtc aggtggcttc tttaatctct atgccttggc agttatgtat   720
acttttggtc tggaactctt ctttgacttt gcaggttatt ctatgtttgc tttggccatc   780
tcaaacttga tgggaatccg tagccctatc aactttaaca agcccttttt atcaagggat   840
ttaaaggagt tttggaatcg ctggcatatg agtctgtcct tctggttccg tgactttgtc   900
tttatgcgaa tggtgatggt gttaaccaga aagaaagtct ttaaaaatcg taatgtaacc   960
tcaagcatgg cctacattgt aaatatgctg attatgggat tttggcatgg tgtgacctgg   1020
tactatatcg cctatggact ctttcatgga ctaggcttgg tcatcaatga tgcctgggtt   1080
cgcaagaaaa aaacgctcaa taaggaacgg aaaaaagcag ggaaggctgc cctacctgag   1140
aatcgctgga ttcagttgct tggcatggtt gtcactttcc atgttgtcat gttgtcattc   1200
ttaatctttt ctggattctt gaataatcta tggtttaaaa aa                      1242

<210>   4564
<211>   414
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   dltB protein (dltB)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904022 (0.E+01)

<400>   4564
Met Met Glu Phe Phe Gln Gln Leu Pro His Leu Glu Pro Tyr Gly Asn 
1               5                   10                  15      

Pro Gln Tyr Phe Val Tyr Val Ile Ala Ala Thr Leu Pro Ile Phe Ile 
            20                  25                  30          

Gly Leu Phe Phe Lys Lys Arg Phe Ala Trp Tyr Glu Val Leu Val Ser 
        35                  40                  45              

Leu Phe Phe Ile Val Thr Met Leu Val Gly Gly Lys Thr Asn Gln Leu 
    50                  55                  60                  

Ala Ala Leu Gly Ile Tyr Leu Cys Trp Glu Ile Leu Leu Leu Leu Phe 
65                  70                  75                  80  

Tyr Lys His Tyr Arg Lys Ser Lys Asp Gly Lys Trp Val Phe Tyr Leu 
                85                  90                  95      

Val Ser Phe Leu Ser Leu Leu Pro Ile Ile Phe Val Lys Val Gln Pro 
            100                 105                 110         

Ala Ile Asn Gly Thr Gln Ser Leu Leu Gly Phe Leu Gly Ile Ser Tyr 
        115                 120                 125             

Leu Thr Phe Arg Ser Val Gly Ile Val Ile Glu Leu Arg Asp Gly Val 
    130                 135                 140                 

Ile Lys Asp Phe Thr Leu Trp Glu Phe Leu Arg Phe Leu Leu Phe Met 
145                 150                 155                 160 

Pro Thr Phe Ser Ser Gly Pro Ile Asp Arg Phe Lys Arg Phe Asn Glu 
                165                 170                 175     

Asn Tyr Gln Ala Ile Pro Glu Arg Asp Glu Leu Met Asp Met Leu Asp 
            180                 185                 190         

Glu Ser Val Arg Tyr Ile Met Trp Gly Phe Leu Tyr Lys Phe Ile Leu 
        195                 200                 205             

Ala His Val Leu Gly Glu Thr Leu Leu Pro Pro Leu Lys Asn Leu Ala 
    210                 215                 220                 

Leu Gln Ser Gly Gly Phe Phe Asn Leu Tyr Ala Leu Ala Val Met Tyr 
225                 230                 235                 240 

Thr Phe Gly Leu Glu Leu Phe Phe Asp Phe Ala Gly Tyr Ser Met Phe 
                245                 250                 255     

Ala Leu Ala Ile Ser Asn Leu Met Gly Ile Arg Ser Pro Ile Asn Phe 
            260                 265                 270         

Asn Lys Pro Phe Leu Ser Arg Asp Leu Lys Glu Phe Trp Asn Arg Trp 
        275                 280                 285             

His Met Ser Leu Ser Phe Trp Phe Arg Asp Phe Val Phe Met Arg Met 
    290                 295                 300                 

Val Met Val Leu Thr Arg Lys Lys Val Phe Lys Asn Arg Asn Val Thr 
305                 310                 315                 320 

Ser Ser Met Ala Tyr Ile Val Asn Met Leu Ile Met Gly Phe Trp His 
                325                 330                 335     

Gly Val Thr Trp Tyr Tyr Ile Ala Tyr Gly Leu Phe His Gly Leu Gly 
            340                 345                 350         

Leu Val Ile Asn Asp Ala Trp Val Arg Lys Lys Lys Thr Leu Asn Lys 
        355                 360                 365             

Glu Arg Lys Lys Ala Gly Lys Ala Ala Leu Pro Glu Asn Arg Trp Ile 
    370                 375                 380                 

Gln Leu Leu Gly Met Val Val Thr Phe His Val Val Met Leu Ser Phe 
385                 390                 395                 400 

Leu Ile Phe Ser Gly Phe Leu Asn Asn Leu Trp Phe Lys Lys 
                405                 410                 

<210>   4565
<211>   1548
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4565
gtgtcaaata aaccaatagc agatatgatt gaaaccattg agcattttgc tcagacacag   60
cctagctatc ctgtctataa tgttttgggg caggaacaca cttatggcga tttaaaggct   120
gattcggata gtttggctgc agtcattgac caactaggct tgcctgagaa gtctcctgtg   180
gttgtttttg gtggccaaga atatgaaatg ttggcaacct ttgtagcgct gactaagtca   240
ggtcatgcct acattccaat tgatagccat tcggccttgg agcgagtttc agctatttta   300
gaagtagcag agccaagctt gattattgcc atttcagcct ttcccttgga gcaggtttct   360
acaccaatga taaatctagc tcaggttcaa gaagcctttg cccaagggaa taactatgaa   420
atcacgcatc cagtcaaggg agatgataat tactacatta tctttacttc tggtacgact   480
ggtaagccta agggagtgca gatttcacat gataatctcc tcagctttac aaactggatg   540
attacggata aggaatttgc gacaccgagt cgtccgcaaa tgctggcaca gccaccttat   600
tcttttgact tgtctgtcat gtattgggca ccgaccttgg cacttggtgg tacgcttttc   660
actcttcctt cagtcatcac tcaggacttt aagcaactct ttgcggctat cttttcattg   720
ccaatcgcta tctggacatc aacaccatcc tttgcagata tggccatgtt gtctgaatac   780
ttcaacagtg agaaaatgcc tggaatcacg catttctact ttgatggtga agaattgacg   840
gtcaaaacag ctcaaaaact gcgcgagcgt ttcccaaatg cccgtatcat caatgcttac   900
ggcccaacag aagcgacagt agctctgtca gcagttgccg tgacagacga gatgttagcg   960
actctcaaac gcctaccaat cggctatacc aaggctgatt ctccaacctt tatcattgac   1020
gaggaaggaa ataaactgcc aaatggtgag cagggagaaa tcattgtttc tgggccagct   1080
gtttcaaaag gttatatgaa caatcctgaa aaaacagcag aagccttctt tgagtttgaa   1140
gatctgccag cctatcacac aggcgatgtg ggaaccatga cagatgaggg cttgcttctc   1200
tacggcggac gcatggactt ccagattaag tttaacggtt accgcattga gttagaagat   1260
gtctctcaaa acctcaacaa gtctcgcttt atcgaatctg ctgtcgcagt accgcgctat   1320
aacaaggacc acaaggtaca aaatctattg gcttatgtca tcttaaaaga cggtgttcgt   1380
gagcagtttg agcgagatat cgatattacc aaggccatca aggaagacct gacagacatc   1440
atgatgtcct atatgatgcc atctaaattc ctttaccgag acagtttgcc actaactcca   1500
aatggaaaga ttgacatcaa aggattgatt aacgaggtga ataagaga                1548

<210>   4566
<211>   516
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   D-alanine-activating enzyme (dltA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904023 (0.E+01)

<400>   4566
Met Ser Asn Lys Pro Ile Ala Asp Met Ile Glu Thr Ile Glu His Phe 
1               5                   10                  15      

Ala Gln Thr Gln Pro Ser Tyr Pro Val Tyr Asn Val Leu Gly Gln Glu 
            20                  25                  30          

His Thr Tyr Gly Asp Leu Lys Ala Asp Ser Asp Ser Leu Ala Ala Val 
        35                  40                  45              

Ile Asp Gln Leu Gly Leu Pro Glu Lys Ser Pro Val Val Val Phe Gly 
    50                  55                  60                  

Gly Gln Glu Tyr Glu Met Leu Ala Thr Phe Val Ala Leu Thr Lys Ser 
65                  70                  75                  80  

Gly His Ala Tyr Ile Pro Ile Asp Ser His Ser Ala Leu Glu Arg Val 
                85                  90                  95      

Ser Ala Ile Leu Glu Val Ala Glu Pro Ser Leu Ile Ile Ala Ile Ser 
            100                 105                 110         

Ala Phe Pro Leu Glu Gln Val Ser Thr Pro Met Ile Asn Leu Ala Gln 
        115                 120                 125             

Val Gln Glu Ala Phe Ala Gln Gly Asn Asn Tyr Glu Ile Thr His Pro 
    130                 135                 140                 

Val Lys Gly Asp Asp Asn Tyr Tyr Ile Ile Phe Thr Ser Gly Thr Thr 
145                 150                 155                 160 

Gly Lys Pro Lys Gly Val Gln Ile Ser His Asp Asn Leu Leu Ser Phe 
                165                 170                 175     

Thr Asn Trp Met Ile Thr Asp Lys Glu Phe Ala Thr Pro Ser Arg Pro 
            180                 185                 190         

Gln Met Leu Ala Gln Pro Pro Tyr Ser Phe Asp Leu Ser Val Met Tyr 
        195                 200                 205             

Trp Ala Pro Thr Leu Ala Leu Gly Gly Thr Leu Phe Thr Leu Pro Ser 
    210                 215                 220                 

Val Ile Thr Gln Asp Phe Lys Gln Leu Phe Ala Ala Ile Phe Ser Leu 
225                 230                 235                 240 

Pro Ile Ala Ile Trp Thr Ser Thr Pro Ser Phe Ala Asp Met Ala Met 
                245                 250                 255     

Leu Ser Glu Tyr Phe Asn Ser Glu Lys Met Pro Gly Ile Thr His Phe 
            260                 265                 270         

Tyr Phe Asp Gly Glu Glu Leu Thr Val Lys Thr Ala Gln Lys Leu Arg 
        275                 280                 285             

Glu Arg Phe Pro Asn Ala Arg Ile Ile Asn Ala Tyr Gly Pro Thr Glu 
    290                 295                 300                 

Ala Thr Val Ala Leu Ser Ala Val Ala Val Thr Asp Glu Met Leu Ala 
305                 310                 315                 320 

Thr Leu Lys Arg Leu Pro Ile Gly Tyr Thr Lys Ala Asp Ser Pro Thr 
                325                 330                 335     

Phe Ile Ile Asp Glu Glu Gly Asn Lys Leu Pro Asn Gly Glu Gln Gly 
            340                 345                 350         

Glu Ile Ile Val Ser Gly Pro Ala Val Ser Lys Gly Tyr Met Asn Asn 
        355                 360                 365             

Pro Glu Lys Thr Ala Glu Ala Phe Phe Glu Phe Glu Asp Leu Pro Ala 
    370                 375                 380                 

Tyr His Thr Gly Asp Val Gly Thr Met Thr Asp Glu Gly Leu Leu Leu 
385                 390                 395                 400 

Tyr Gly Gly Arg Met Asp Phe Gln Ile Lys Phe Asn Gly Tyr Arg Ile 
                405                 410                 415     

Glu Leu Glu Asp Val Ser Gln Asn Leu Asn Lys Ser Arg Phe Ile Glu 
            420                 425                 430         

Ser Ala Val Ala Val Pro Arg Tyr Asn Lys Asp His Lys Val Gln Asn 
        435                 440                 445             

Leu Leu Ala Tyr Val Ile Leu Lys Asp Gly Val Arg Glu Gln Phe Glu 
    450                 455                 460                 

Arg Asp Ile Asp Ile Thr Lys Ala Ile Lys Glu Asp Leu Thr Asp Ile 
465                 470                 475                 480 

Met Met Ser Tyr Met Met Pro Ser Lys Phe Leu Tyr Arg Asp Ser Leu 
                485                 490                 495     

Pro Leu Thr Pro Asn Gly Lys Ile Asp Ile Lys Gly Leu Ile Asn Glu 
            500                 505                 510         

Val Asn Lys Arg 
        515     

<210>   4567
<211>   132
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4567
ttgatgaaac agagaaaaga attgtacctc tttcttggtc ggacagcctt gtattttctt   60
atctttctag ggctgcttta cttctttagc tatcttggtc agggtcaagg aagctttatc   120
tataatgaat tt                                                       132

<210>   4568
<211>   44
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane

<400>   4568
Met Met Lys Gln Arg Lys Glu Leu Tyr Leu Phe Leu Gly Arg Thr Ala 
1               5                   10                  15      

Leu Tyr Phe Leu Ile Phe Leu Gly Leu Leu Tyr Phe Phe Ser Tyr Leu 
            20                  25                  30          

Gly Gln Gly Gln Gly Ser Phe Ile Tyr Asn Glu Phe 
        35                  40                  

<210>   4569
<211>   306
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4569
gtgacactga ctattctata ttttccaaac gcacagatgt ttttattatt ttcagcttta   60
gttggtatgt tatcgcaact aaaagaagtt cctgaaagtg tatttcttca ggaaacagta   120
gaggaaaatc atttagttaa tgtctattcc gttcttgaag tgatttctac attagcattt   180
tcagtatttg ttttgctaat gagctatatt actgagagtt ttggtattag catcagtttt   240
tggctatcag ccatttgtct gatgatagaa gctattttaa tttatatcag acgagattat   300
tttaaa                                                              306

<210>   4570
<211>   102
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, interruption
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904024 (2.E-51)

<400>   4570
Met Thr Leu Thr Ile Leu Tyr Phe Pro Asn Ala Gln Met Phe Leu Leu 
1               5                   10                  15      

Phe Ser Ala Leu Val Gly Met Leu Ser Gln Leu Lys Glu Val Pro Glu 
            20                  25                  30          

Ser Val Phe Leu Gln Glu Thr Val Glu Glu Asn His Leu Val Asn Val 
        35                  40                  45              

Tyr Ser Val Leu Glu Val Ile Ser Thr Leu Ala Phe Ser Val Phe Val 
    50                  55                  60                  

Leu Leu Met Ser Tyr Ile Thr Glu Ser Phe Gly Ile Ser Ile Ser Phe 
65                  70                  75                  80  

Trp Leu Ser Ala Ile Cys Leu Met Ile Glu Ala Ile Leu Ile Tyr Ile 
                85                  90                  95      

Arg Arg Asp Tyr Phe Lys 
            100         

<210>   4571
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4571
atgaacagtt taccaaatca tcacttccaa aacaagtctt tttaccaact atctttcgat   60
ggaggtcatt taacccagta tggtggtctt atcttttttc aggaactttt ttcccagttg   120
aaactaaaag agcggatttc taagtattta gtaacgaatg accaacgccg ctactgtcgt   180
tattcggatt cagatatcct tgtccagttc ctctttcaac tgttaacagg ttatggaacg   240
gactatgctt gtaaagaatt gtcagctgat gcctactttc caaaattgtt ggaaggaggg   300
cagcttgctt cacagccaac cttatcccgt tttctttcca gaactgacga ggaaacagtc   360
catagtttgc gatgcctcaa ccttgaattg gtcgaattct ttttacagtt tcaccagcta   420
aaccaactca ttgtagatat cgattctacc catttcacaa cttatggcaa gcaagaaggt   480
gttgcttata acgcccacta tcgtgctcat ggctatcatc ctctttatgc tttcgagggg   540
aagacaggtt attgtttcaa tgcccagctt cgtcctggta atcgttattg ttctgaagag   600
gcagacagct ttatcacacc tgttttagaa cggtttaatc aacttctctt tcgaatggat   660
agtggctttg cgaccccaaa attatacgat ttaattgaaa aaacagggca atactacctc   720
ataaaactca agaaaaatac tgttctgagc cgtcttggag acctttccct cccttgccca   780
caggatgagg acttaaccat cttgccccac tccgcctact cagaaactct ctatcaagca   840
ggatcttggt cgcacaagcg tcgtgtctgc cagttctctg aacgaaaaga aggaaacttg   900
ttctacgatg ttatttctct cgttacaaat atgacgagtg gaacaagcca agaccagttt   960
cagctttatc gtggacgtgg tcaagccgag aatttcatca aggagatgaa ggagggattt   1020
tttggcgata aaacggatag ttcaacctta atcaaaaacg aagttcgtat gatgatgagc   1080
tgtatcgcct acaatctcta tctttttctc aaacatctag ctggaggtga cttccaaact   1140
ttaacaatca aacgcttccg ccatcttttt cttcacgtgg tgggaaaatg tgttcgaaca   1200
ggacgcaagc agctcctcaa attgtctagt ctctatgcct attccgaatt gttttcagca   1260
ctttattcta ggattagaaa agtcaacctg aatcttcctg ttccttatga accacctaga   1320
agaaaagcgt cgttaatgat gcat                                          1344

<210>   4572
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1380-Spn1, transposase
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903941 (2.E-46)

<400>   4572
Met Asn Ser Leu Pro Asn His His Phe Gln Asn Lys Ser Phe Tyr Gln 
1               5                   10                  15      

Leu Ser Phe Asp Gly Gly His Leu Thr Gln Tyr Gly Gly Leu Ile Phe 
            20                  25                  30          

Phe Gln Glu Leu Phe Ser Gln Leu Lys Leu Lys Glu Arg Ile Ser Lys 
        35                  40                  45              

Tyr Leu Val Thr Asn Asp Gln Arg Arg Tyr Cys Arg Tyr Ser Asp Ser 
    50                  55                  60                  

Asp Ile Leu Val Gln Phe Leu Phe Gln Leu Leu Thr Gly Tyr Gly Thr 
65                  70                  75                  80  

Asp Tyr Ala Cys Lys Glu Leu Ser Ala Asp Ala Tyr Phe Pro Lys Leu 
                85                  90                  95      

Leu Glu Gly Gly Gln Leu Ala Ser Gln Pro Thr Leu Ser Arg Phe Leu 
            100                 105                 110         

Ser Arg Thr Asp Glu Glu Thr Val His Ser Leu Arg Cys Leu Asn Leu 
        115                 120                 125             

Glu Leu Val Glu Phe Phe Leu Gln Phe His Gln Leu Asn Gln Leu Ile 
    130                 135                 140                 

Val Asp Ile Asp Ser Thr His Phe Thr Thr Tyr Gly Lys Gln Glu Gly 
145                 150                 155                 160 

Val Ala Tyr Asn Ala His Tyr Arg Ala His Gly Tyr His Pro Leu Tyr 
                165                 170                 175     

Ala Phe Glu Gly Lys Thr Gly Tyr Cys Phe Asn Ala Gln Leu Arg Pro 
            180                 185                 190         

Gly Asn Arg Tyr Cys Ser Glu Glu Ala Asp Ser Phe Ile Thr Pro Val 
        195                 200                 205             

Leu Glu Arg Phe Asn Gln Leu Leu Phe Arg Met Asp Ser Gly Phe Ala 
    210                 215                 220                 

Thr Pro Lys Leu Tyr Asp Leu Ile Glu Lys Thr Gly Gln Tyr Tyr Leu 
225                 230                 235                 240 

Ile Lys Leu Lys Lys Asn Thr Val Leu Ser Arg Leu Gly Asp Leu Ser 
                245                 250                 255     

Leu Pro Cys Pro Gln Asp Glu Asp Leu Thr Ile Leu Pro His Ser Ala 
            260                 265                 270         

Tyr Ser Glu Thr Leu Tyr Gln Ala Gly Ser Trp Ser His Lys Arg Arg 
        275                 280                 285             

Val Cys Gln Phe Ser Glu Arg Lys Glu Gly Asn Leu Phe Tyr Asp Val 
    290                 295                 300                 

Ile Ser Leu Val Thr Asn Met Thr Ser Gly Thr Ser Gln Asp Gln Phe 
305                 310                 315                 320 

Gln Leu Tyr Arg Gly Arg Gly Gln Ala Glu Asn Phe Ile Lys Glu Met 
                325                 330                 335     

Lys Glu Gly Phe Phe Gly Asp Lys Thr Asp Ser Ser Thr Leu Ile Lys 
            340                 345                 350         

Asn Glu Val Arg Met Met Met Ser Cys Ile Ala Tyr Asn Leu Tyr Leu 
        355                 360                 365             

Phe Leu Lys His Leu Ala Gly Gly Asp Phe Gln Thr Leu Thr Ile Lys 
    370                 375                 380                 

Arg Phe Arg His Leu Phe Leu His Val Val Gly Lys Cys Val Arg Thr 
385                 390                 395                 400 

Gly Arg Lys Gln Leu Leu Lys Leu Ser Ser Leu Tyr Ala Tyr Ser Glu 
                405                 410                 415     

Leu Phe Ser Ala Leu Tyr Ser Arg Ile Arg Lys Val Asn Leu Asn Leu 
            420                 425                 430         

Pro Val Pro Tyr Glu Pro Pro Arg Arg Lys Ala Ser Leu Met Met His 
        435                 440                 445             


<210>   4573
<211>   384
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4573
ttgaagaaac taacacagag gaaatggagt atagacctaa caagacgtat tgagcaactg   60
aatttgtcta ttcgaggatg gataaactat tgctcattgg gaaatatgaa aagtatagtc   120
gccagcatag atgagcgctt gcgtactcgc ctacgagtga ttatctggaa gcaatggaag   180
aagaaatcga gacgattatg gggattgctt aagttaggag ttcctaaatg gatagcagat   240
aaggtatctg gctggggcga ccattatcaa ttagtagctc agaagtcggt acttaaacgt   300
gctatatcaa aaccagtcct ggaaaaacgt ggactggttt cgtgtttgga ttattacctt   360
gaacgacatg cgttaaaagt tagt                                          384

<210>   4574
<211>   128
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   maturase-related protein-related

<400>   4574
Met Lys Lys Leu Thr Gln Arg Lys Trp Ser Ile Asp Leu Thr Arg Arg 
1               5                   10                  15      

Ile Glu Gln Leu Asn Leu Ser Ile Arg Gly Trp Ile Asn Tyr Cys Ser 
            20                  25                  30          

Leu Gly Asn Met Lys Ser Ile Val Ala Ser Ile Asp Glu Arg Leu Arg 
        35                  40                  45              


Thr Arg Leu Arg Val Ile Ile Trp Lys Gln Trp Lys Lys Lys Ser Arg 
    50                  55                  60                  

Arg Leu Trp Gly Leu Leu Lys Leu Gly Val Pro Lys Trp Ile Ala Asp 
65                  70                  75                  80  

Lys Val Ser Gly Trp Gly Asp His Tyr Gln Leu Val Ala Gln Lys Ser 
                85                  90                  95      

Val Leu Lys Arg Ala Ile Ser Lys Pro Val Leu Glu Lys Arg Gly Leu 
            100                 105                 110         

Val Ser Cys Leu Asp Tyr Tyr Leu Glu Arg His Ala Leu Lys Val Ser 
        115                 120                 125             


<210>   4575
<211>   447
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4575
gtggatagtg gattagacct agagaaattt ttcgatacag ttcctcaaga tagattgatg   60
tccttagtac ataacattat cgaagacgga gatacggaat ccttgattcg taagtatctt   120
cattcaggtg ttatcattaa tggtcaacgt tataaaacac tagttggtac accacaggga   180
ggaaatttat ctcctctctt atccaatatc atgcttaatg aattggacaa ggaattagaa   240
aagaggggac ttcgatttgt gcgctacgca gatgattgtg tgattacggt cggaagcgag   300
gcagcctcta agcgtgtgat gtattcagtc agtcgtttta ttgagaaacg gctaggtttg   360
aaagtaaaca tgaccaagag agttgaaata tctaggtttt gggttctgga aattatcaga   420
tggttggaaa agccgtccac atcaaga                                       447

<210>   4576
<211>   149
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   maturase-related protein

<400>   4576
Met Asp Ser Gly Leu Asp Leu Glu Lys Phe Phe Asp Thr Val Pro Gln 
1               5                   10                  15      

Asp Arg Leu Met Ser Leu Val His Asn Ile Ile Glu Asp Gly Asp Thr 
            20                  25                  30          

Glu Ser Leu Ile Arg Lys Tyr Leu His Ser Gly Val Ile Ile Asn Gly 
        35                  40                  45              

Gln Arg Tyr Lys Thr Leu Val Gly Thr Pro Gln Gly Gly Asn Leu Ser 
    50                  55                  60                  

Pro Leu Leu Ser Asn Ile Met Leu Asn Glu Leu Asp Lys Glu Leu Glu 
65                  70                  75                  80  

Lys Arg Gly Leu Arg Phe Val Arg Tyr Ala Asp Asp Cys Val Ile Thr 
                85                  90                  95      

Val Gly Ser Glu Ala Ala Ser Lys Arg Val Met Tyr Ser Val Ser Arg 
            100                 105                 110         

Phe Ile Glu Lys Arg Leu Gly Leu Lys Val Asn Met Thr Lys Arg Val 
        115                 120                 125             

Glu Ile Ser Arg Phe Trp Val Leu Glu Ile Ile Arg Trp Leu Glu Lys 
    130                 135                 140                 

Pro Ser Thr Ser Arg 
145                 

<210>   4577
<211>   411
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4577
atgtcaaaac tgctagataa gatattatca cgcgaaaata tgctggaagc ctacaatcaa   60
gtaaaatcca ataaaggctc agctgggatt gatggaatga ctatcgaaga gatggataat   120
tatctcagac aaaactggcg cttgactaag gaactgataa aacagagaaa atataagcct   180
caaccagttc ttagagttga gatacctaaa ccagacggag gcatccgtca actaggaatt   240
ccaacagtta tggatagaat gattcaacag gccattgtcc aagtcatgag ccccatttgt   300
gaaccccatt tctcagatac gagttatggt ttcagaccaa ataggtcatg tgaaaaagcc   360
atcatgaagc tcttagaata cttaaatgac ggctatgagt ggatagtgga t            411

<210>   4578
<211>   137
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   group II intron, maturase FRAMESHIFT

<400>   4578
Met Ser Lys Leu Leu Asp Lys Ile Leu Ser Arg Glu Asn Met Leu Glu 
1               5                   10                  15      

Ala Tyr Asn Gln Val Lys Ser Asn Lys Gly Ser Ala Gly Ile Asp Gly 
            20                  25                  30          

Met Thr Ile Glu Glu Met Asp Asn Tyr Leu Arg Gln Asn Trp Arg Leu 
        35                  40                  45              

Thr Lys Glu Leu Ile Lys Gln Arg Lys Tyr Lys Pro Gln Pro Val Leu 
    50                  55                  60                  

Arg Val Glu Ile Pro Lys Pro Asp Gly Gly Ile Arg Gln Leu Gly Ile 
65                  70                  75                  80  

Pro Thr Val Met Asp Arg Met Ile Gln Gln Ala Ile Val Gln Val Met 
                85                  90                  95      

Ser Pro Ile Cys Glu Pro His Phe Ser Asp Thr Ser Tyr Gly Phe Arg 
            100                 105                 110         

Pro Asn Arg Ser Cys Glu Lys Ala Ile Met Lys Leu Leu Glu Tyr Leu 
        115                 120                 125             

Asn Asp Gly Tyr Glu Trp Ile Val Asp 
    130                 135         

<210>   4579
<211>   585
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4579
ttgtttgttt ttgctgatga tagcttatcg gcaaactcta aagttgtatc tggtgaggct   60
cagtttgaga atggctcatc agtgcggttc ggagatacgc aagtaaatat tttaagcgat   120

gaagttcttg aggttgtcaa tccagatgga agtgtagaca ctattgaacg acgtgctgac   180
ggcgtctata tcaatggggc attttatatg gcttatcaaa agaatgaaat cgacctaaat   240
atatctttta gatcatacga tcctaatgtt tggaattacg tcaacacaat acatgggaat   300
aaacaagcta acacattcgc taacttcatg actggtgctg gaatcagtta tatgattggt   360
aggataggtg ctttattggg gggtccatgg ggtgcaataa ttggtggagc atattttggt   420
atacaagctt atcagtctta cttggattca caaagcccat atccatacta cataacaagt   480
acttatatcc atgttgctca aagaaaatgg aagtttatca ctgaatacta tagaaactca   540
aactatactg ggtatgtaaa aaccgtaaca acctacgtga atttc                   585

<210>   4580
<211>   195
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904024 (e-149)

<400>   4580
Met Phe Val Phe Ala Asp Asp Ser Leu Ser Ala Asn Ser Lys Val Val 
1               5                   10                  15      

Ser Gly Glu Ala Gln Phe Glu Asn Gly Ser Ser Val Arg Phe Gly Asp 
            20                  25                  30          

Thr Gln Val Asn Ile Leu Ser Asp Glu Val Leu Glu Val Val Asn Pro 
        35                  40                  45              

Asp Gly Ser Val Asp Thr Ile Glu Arg Arg Ala Asp Gly Val Tyr Ile 
    50                  55                  60                  

Asn Gly Ala Phe Tyr Met Ala Tyr Gln Lys Asn Glu Ile Asp Leu Asn 
65                  70                  75                  80  

Ile Ser Phe Arg Ser Tyr Asp Pro Asn Val Trp Asn Tyr Val Asn Thr 
                85                  90                  95      

Ile His Gly Asn Lys Gln Ala Asn Thr Phe Ala Asn Phe Met Thr Gly 
            100                 105                 110         

Ala Gly Ile Ser Tyr Met Ile Gly Arg Ile Gly Ala Leu Leu Gly Gly 
        115                 120                 125             

Pro Trp Gly Ala Ile Ile Gly Gly Ala Tyr Phe Gly Ile Gln Ala Tyr 
    130                 135                 140                 

Gln Ser Tyr Leu Asp Ser Gln Ser Pro Tyr Pro Tyr Tyr Ile Thr Ser 
145                 150                 155                 160 

Thr Tyr Ile His Val Ala Gln Arg Lys Trp Lys Phe Ile Thr Glu Tyr 
                165                 170                 175     

Tyr Arg Asn Ser Asn Tyr Thr Gly Tyr Val Lys Thr Val Thr Thr Tyr 
            180                 185                 190         

Val Asn Phe 
        195 

<210>   4581
<211>   201
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4581
gtgccgaaat ggtcaaatcc tgattatgtc aacgaattag acccaaaaat cgttgatatg   60
ctagtagaat ttcacaagtc acaaggcact ttggaaactc ccgaggcgca agcagaaatc   120
gcccaaaaac gtgaagaaat cgagcaaagg agagctgagc ttgagggtaa aaaacaagag   180
cttttgaacc gcttgaacaa a                                             201

<210>   4582
<211>   67
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904028 (6.E-35)

<400>   4582
Met Pro Lys Trp Ser Asn Pro Asp Tyr Val Asn Glu Leu Asp Pro Lys 
1               5                   10                  15      

Ile Val Asp Met Leu Val Glu Phe His Lys Ser Gln Gly Thr Leu Glu 
            20                  25                  30          

Thr Pro Glu Ala Gln Ala Glu Ile Ala Gln Lys Arg Glu Glu Ile Glu 
        35                  40                  45              

Gln Arg Arg Ala Glu Leu Glu Gly Lys Lys Gln Glu Leu Leu Asn Arg 
    50                  55                  60                  

Leu Asn Lys 
65          

<210>   4583
<211>   123
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4583
gtgcttgata tgatgcgttt tattatgaga agatttactt cattttttgc tgaaattggg   60
ctcttgccca agctctatca acataattgt tttctaatac tcaatgaaaa tcaaagagca   120
aac                                                                 123

<210>   4584
<211>   41
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4584
Met Leu Asp Met Met Arg Phe Ile Met Arg Arg Phe Thr Ser Phe Phe 
1               5                   10                  15      

Ala Glu Ile Gly Leu Leu Pro Lys Leu Tyr Gln His Asn Cys Phe Leu 
            20                  25                  30          

Ile Leu Asn Glu Asn Gln Arg Ala Asn 
        35                  40      

<210>   4585
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4585
gtggagggca gcattccttg tcgcccgtcc cttcttttta atggagacag aaagatgatg   60
aatgaattat ttggagaatt tctagggact ttaatcctga ttcttctagg aaatggtgtt   120
gttgcaggtg tggttcttcc taaaaccaag agcaatagct caggttggat tgtgattact   180
atgggttggg ggattgcagt tgcggttgca gtctttgtat ctggcaagct cagtccagct   240
tatttaaacc cagctgtgac catcggtgtg gccttaaaag gtggtttgcc ttgggcttcc   300
gttttgcctt atatcttagc ccagttcgca ggggccatgc tgggtcagat tttggtttgg   360
ttgcaattca aacctcacta tgaggcagaa gaaaatgcag gcaatatcct ggcaaccttc   420
agtactggac cagccatcaa ggatactgta tcaaacttga ttagcgaaat ccttggaact   480
tttgttttgg tgttgacaat ctttgctttg ggtctttacg actttcaggc aggtatcgga   540
acctttgcag tgggaacttt gattgtcggt atcggtctat cactaggtgg gacaacaggt   600
tatgccttga acccagctcg tgaccttgga cctcgtatca tgcacagcat cttgccaatt   660
ccaaacaagg gagacggaga ctggtcttac gcttggattc ctgttgtagg ccctgttatc   720
ggagcagcct tggcagtgct tgtattctca cttttc                             756

<210>   4586
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycerol uptake facilitator protein (glpF)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904029 (e-132)

<400>   4586
Met Glu Gly Ser Ile Pro Cys Arg Pro Ser Leu Leu Phe Asn Gly Asp 
1               5                   10                  15      

Arg Lys Met Met Asn Glu Leu Phe Gly Glu Phe Leu Gly Thr Leu Ile 
            20                  25                  30          

Leu Ile Leu Leu Gly Asn Gly Val Val Ala Gly Val Val Leu Pro Lys 
        35                  40                  45              

Thr Lys Ser Asn Ser Ser Gly Trp Ile Val Ile Thr Met Gly Trp Gly 
    50                  55                  60                  

Ile Ala Val Ala Val Ala Val Phe Val Ser Gly Lys Leu Ser Pro Ala 
65                  70                  75                  80  

Tyr Leu Asn Pro Ala Val Thr Ile Gly Val Ala Leu Lys Gly Gly Leu 
                85                  90                  95      

Pro Trp Ala Ser Val Leu Pro Tyr Ile Leu Ala Gln Phe Ala Gly Ala 
            100                 105                 110         

Met Leu Gly Gln Ile Leu Val Trp Leu Gln Phe Lys Pro His Tyr Glu 
        115                 120                 125             

Ala Glu Glu Asn Ala Gly Asn Ile Leu Ala Thr Phe Ser Thr Gly Pro 
    130                 135                 140                 

Ala Ile Lys Asp Thr Val Ser Asn Leu Ile Ser Glu Ile Leu Gly Thr 
145                 150                 155                 160 

Phe Val Leu Val Leu Thr Ile Phe Ala Leu Gly Leu Tyr Asp Phe Gln 
                165                 170                 175     

Ala Gly Ile Gly Thr Phe Ala Val Gly Thr Leu Ile Val Gly Ile Gly 
            180                 185                 190         

Leu Ser Leu Gly Gly Thr Thr Gly Tyr Ala Leu Asn Pro Ala Arg Asp 
        195                 200                 205             

Leu Gly Pro Arg Ile Met His Ser Ile Leu Pro Ile Pro Asn Lys Gly 
    210                 215                 220                 

Asp Gly Asp Trp Ser Tyr Ala Trp Ile Pro Val Val Gly Pro Val Ile 
225                 230                 235                 240 

Gly Ala Ala Leu Ala Val Leu Val Phe Ser Leu Phe 
                245                 250         

<210>   4587
<211>   1824
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4587
atggaatttt caaagaaaac acgtgaattg tcaattaaaa aaatgcagga acgtaccctg   60
gacctcttga ttatcggtgg aggaatcaca ggagctggtg tagccttgca ggcggcagct   120
agcggtcttg agactggttt gattgaaatg caagactttg cagaaggaac atctagtcgt   180
tcaacaaaat tggttcacgg aggacttcgt tacctcaaac aatttgacgt agaagtggtc   240
tcagatacgg tttctgaacg tgcagtggtt caacaaatcg ctccacacat tccaaaatca   300
gatccaatgc tcttaccagt ttacgatgaa gatggagcaa cctttagcct cttccgtctt   360
aaagtagcca tggacttgta cgacctcttg gcaggtgtta gcaacacacc agctgcgaac   420
aaggttttga gcaaggatca agtcttggaa cgccagccaa acttgaagaa ggaaggcttg   480
gtaggaggtg gagtgtatct tgacttccgt aacaacgatg cgcgtctcgt gattgaaaac   540
atcaaacgtg ccaaccaaga cggtgccctc attgccaacc acgtgaaggc agaaggcttc   600
ctctttgacg aaagtggcaa gattacaggt gttgtagctc gtgatctctt gacagaccaa   660
gtgtttgaaa tcaaggcccg tctggttatt aatacaacag gtccttggag tgataaagta   720
cgtaatttgt ctaataaggg aacgcaattc tcacaaatgc gcccaactaa gggagttcac   780
ttggtagtag attcaagcaa aatcaaggtt tcacagccag tttacttcga cacaggtttg   840
ggtgacggtc gtatggtctt tgttctccca cgtgaaaaca agacttactt tggtacaact   900

gatacagact acacaggtga tttggagcat ccaaaagtaa ctcaagaaga tgtagattat   960
ctacttggca ttgtcaacaa ccgcttccca gaatccaaca tcaccattga tgatatcgaa   1020
agcagctggg caggtcttcg tccattgatt gcagggaaca gtgcctctga ctataatggt   1080
ggaaataacg gtaccatcag tgatgaaagc tttgacaact tgattgcgac tgttgaatct   1140
tatctctcca aagaaaaaac acgtgaagat gttgagtctg ctgtcagcaa gcttgaaagt   1200
agcacatctg agaaacattt ggatccatct gcagtttctc gtgggtctag cttggaccgt   1260
gatgacaatg gtctcttgac tcttgctggt ggtaaaatca cagactaccg taagatggct   1320
gaaggagcta tggagcgcgt ggttgacatc ctcaaagcag aatttgaccg tagctttaaa   1380
ttgatcaatt ctaaaactta ccctgtttca ggtggagaat tgaacccagc aaatgtggat   1440
tcagaaatcg aagcctttgc gcaacttgga gtatcacgtg gtttggatag caaggaagct   1500
cactatctgg caaatcttta cggttcaaat gcaccgaaag tctttgcact tgctcacagc   1560
ttggaacaag cgccaggact cagcttggca gatactttgt cccttcacta tgcaatgcgc   1620
aatgagttga ctcttagccc agttgacttc cttcttcgtc gtaccaatca catgctcttt   1680
atgcgtgata gcttggatag tatcgttgag ccaattttgg atgaaatggg acgattctat   1740
gactggacag aagaagaaaa agcaacttac cgtgctgatg tcgaagcagc tctcgctaac   1800
aacgatttag cagaattaaa aaat                                          1824

<210>   4588
<211>   608
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein (Glycerol-3-phosphate dehydrogenase)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15904031 (0.E+01)

<400>   4588
Met Glu Phe Ser Lys Lys Thr Arg Glu Leu Ser Ile Lys Lys Met Gln 
1               5                   10                  15      

Glu Arg Thr Leu Asp Leu Leu Ile Ile Gly Gly Gly Ile Thr Gly Ala 
            20                  25                  30          

Gly Val Ala Leu Gln Ala Ala Ala Ser Gly Leu Glu Thr Gly Leu Ile 
        35                  40                  45              

Glu Met Gln Asp Phe Ala Glu Gly Thr Ser Ser Arg Ser Thr Lys Leu 
    50                  55                  60                  

Val His Gly Gly Leu Arg Tyr Leu Lys Gln Phe Asp Val Glu Val Val 
65                  70                  75                  80  

Ser Asp Thr Val Ser Glu Arg Ala Val Val Gln Gln Ile Ala Pro His 
                85                  90                  95      

Ile Pro Lys Ser Asp Pro Met Leu Leu Pro Val Tyr Asp Glu Asp Gly 
            100                 105                 110         

Ala Thr Phe Ser Leu Phe Arg Leu Lys Val Ala Met Asp Leu Tyr Asp 
        115                 120                 125             

Leu Leu Ala Gly Val Ser Asn Thr Pro Ala Ala Asn Lys Val Leu Ser 
    130                 135                 140                 

Lys Asp Gln Val Leu Glu Arg Gln Pro Asn Leu Lys Lys Glu Gly Leu 
145                 150                 155                 160 

Val Gly Gly Gly Val Tyr Leu Asp Phe Arg Asn Asn Asp Ala Arg Leu 
                165                 170                 175     

Val Ile Glu Asn Ile Lys Arg Ala Asn Gln Asp Gly Ala Leu Ile Ala 
            180                 185                 190         

Asn His Val Lys Ala Glu Gly Phe Leu Phe Asp Glu Ser Gly Lys Ile 
        195                 200                 205             

Thr Gly Val Val Ala Arg Asp Leu Leu Thr Asp Gln Val Phe Glu Ile 
    210                 215                 220                 

Lys Ala Arg Leu Val Ile Asn Thr Thr Gly Pro Trp Ser Asp Lys Val 
225                 230                 235                 240 

Arg Asn Leu Ser Asn Lys Gly Thr Gln Phe Ser Gln Met Arg Pro Thr 
                245                 250                 255     

Lys Gly Val His Leu Val Val Asp Ser Ser Lys Ile Lys Val Ser Gln 
            260                 265                 270         

Pro Val Tyr Phe Asp Thr Gly Leu Gly Asp Gly Arg Met Val Phe Val 
        275                 280                 285             

Leu Pro Arg Glu Asn Lys Thr Tyr Phe Gly Thr Thr Asp Thr Asp Tyr 
    290                 295                 300                 

Thr Gly Asp Leu Glu His Pro Lys Val Thr Gln Glu Asp Val Asp Tyr 
305                 310                 315                 320 

Leu Leu Gly Ile Val Asn Asn Arg Phe Pro Glu Ser Asn Ile Thr Ile 
                325                 330                 335     

Asp Asp Ile Glu Ser Ser Trp Ala Gly Leu Arg Pro Leu Ile Ala Gly 
            340                 345                 350         

Asn Ser Ala Ser Asp Tyr Asn Gly Gly Asn Asn Gly Thr Ile Ser Asp 
        355                 360                 365             

Glu Ser Phe Asp Asn Leu Ile Ala Thr Val Glu Ser Tyr Leu Ser Lys 
    370                 375                 380                 

Glu Lys Thr Arg Glu Asp Val Glu Ser Ala Val Ser Lys Leu Glu Ser 
385                 390                 395                 400 

Ser Thr Ser Glu Lys His Leu Asp Pro Ser Ala Val Ser Arg Gly Ser 
                405                 410                 415     

Ser Leu Asp Arg Asp Asp Asn Gly Leu Leu Thr Leu Ala Gly Gly Lys 

            420                 425                 430         

Ile Thr Asp Tyr Arg Lys Met Ala Glu Gly Ala Met Glu Arg Val Val 
        435                 440                 445             

Asp Ile Leu Lys Ala Glu Phe Asp Arg Ser Phe Lys Leu Ile Asn Ser 
    450                 455                 460                 

Lys Thr Tyr Pro Val Ser Gly Gly Glu Leu Asn Pro Ala Asn Val Asp 
465                 470                 475                 480 

Ser Glu Ile Glu Ala Phe Ala Gln Leu Gly Val Ser Arg Gly Leu Asp 
                485                 490                 495     

Ser Lys Glu Ala His Tyr Leu Ala Asn Leu Tyr Gly Ser Asn Ala Pro 
            500                 505                 510         

Lys Val Phe Ala Leu Ala His Ser Leu Glu Gln Ala Pro Gly Leu Ser 
        515                 520                 525             

Leu Ala Asp Thr Leu Ser Leu His Tyr Ala Met Arg Asn Glu Leu Thr 
    530                 535                 540                 

Leu Ser Pro Val Asp Phe Leu Leu Arg Arg Thr Asn His Met Leu Phe 
545                 550                 555                 560 

Met Arg Asp Ser Leu Asp Ser Ile Val Glu Pro Ile Leu Asp Glu Met 
                565                 570                 575     

Gly Arg Phe Tyr Asp Trp Thr Glu Glu Glu Lys Ala Thr Tyr Arg Ala 
            580                 585                 590         

Asp Val Glu Ala Ala Leu Ala Asn Asn Asp Leu Ala Glu Leu Lys Asn 
        595                 600                 605             


<210>   4589
<211>   1506
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4589
atgtcacaag aaaaatacat catggccatt gaccagggaa ctacaagttc tcgtgccatc   60
attttcaaca aaaaagggga aaaggttagc tcgagtcaaa aagagtttac ccagattttc   120
cctcaggcag gttgggttga gcacaatgcc aatgaaattt ggaactctgt tcagtcagtt   180
attgcgggtg ctttcatcga aagtggtgtc aagccaaatc aaatcgaggc aatcgggatt   240
accaaccaac gtgaaacaac ggttgtctgg gataagaaaa caggacttcc tatctacaat   300
gctatcgttt ggcagtcacg ccagacagca cctttggctg agcaactaaa aagccaaggt   360
tatgtggaaa aattccatga aaagactggt ttgattattg atgcttactt ctctgctacc   420
aaggttcgtt ggattttgga tcatgtagaa ggtgctcaag agcgagcaga aaaaggggaa   480
ttgctctttg gtactatcga tacttggttg gtttggaaat tgactgacgg tgcggctcac   540
gtgactgact actcaaatgc agctcgtacc atgctttata acattaaaga actcaaatgg   600
gatgatgaga ttttggaaat ccttaacatt ccgaaggcta tacttccaga agttcgttct   660
aactccgaaa tctacggcaa gacagctcca ttccatttct acggtggaga ggtgccaatc   720
tcaggtatgg ctggggacca acaagcagcc ctctttggac agttggcttt tgagccaggt   780
atggttaaga atacttatgg aacaggctct ttcatcatca tgaatactgg ggaagagatg   840
cagttgtctg aaaacaacct cttgacaacc attggttacg gaatcaacgg taaggtttat   900
tatgccttgg aaggttctat cttcatcgca ggaagtgcta ttcagtggct tcgtgacggt   960
cttcgcatgg ttgaaaattc accagaatct gaaaaatacg ctcgtgattc tcacaacaac   1020
gatgaagttt atgtcgttcc agcctttaca ggtctaggcg ctccatactg gaaccaaaat   1080
gctcgtggtt ccgtctttgg tttgactcgt ggaacaagca aagaagactt tatcaaggcg   1140
actttgcaat ctattgctta tcaagtgcgt gatatcatcg acaccatgca agtggatact   1200
cagaccgcca ttcaagtact gaaggtggat ggtggtgcag ccatgaacaa cttcctcatg   1260
cagttccagg cggatatttt aggcattgac attgcacgtg ctaaaaacct ggaaacaaca   1320
gctctaggag cggccttcct agcaggtttg tcagtagggt actggaaaga cttggacgag   1380
ttgaaactct tgaacgagac aggagaactc tttgagccat ctatgaacga atctcgcaag   1440
gaacaactct acaagggctg gaagaaggct gtgaaagcaa ctcaagtctt tgcggaagta   1500
gacgac                                                              1506

<210>   4590
<211>   502
<212>   PRT

<213>   Streptococcus pneumoniae

<220>
<223>   glycerol kinase (gplK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904032 (0.E+01)

<400>   4590
Met Ser Gln Glu Lys Tyr Ile Met Ala Ile Asp Gln Gly Thr Thr Ser 
1               5                   10                  15      

Ser Arg Ala Ile Ile Phe Asn Lys Lys Gly Glu Lys Val Ser Ser Ser 
            20                  25                  30          

Gln Lys Glu Phe Thr Gln Ile Phe Pro Gln Ala Gly Trp Val Glu His 
        35                  40                  45              

Asn Ala Asn Glu Ile Trp Asn Ser Val Gln Ser Val Ile Ala Gly Ala 
    50                  55                  60                  

Phe Ile Glu Ser Gly Val Lys Pro Asn Gln Ile Glu Ala Ile Gly Ile 
65                  70                  75                  80  

Thr Asn Gln Arg Glu Thr Thr Val Val Trp Asp Lys Lys Thr Gly Leu 
                85                  90                  95      

Pro Ile Tyr Asn Ala Ile Val Trp Gln Ser Arg Gln Thr Ala Pro Leu 
            100                 105                 110         

Ala Glu Gln Leu Lys Ser Gln Gly Tyr Val Glu Lys Phe His Glu Lys 
        115                 120                 125             

Thr Gly Leu Ile Ile Asp Ala Tyr Phe Ser Ala Thr Lys Val Arg Trp 
    130                 135                 140                 

Ile Leu Asp His Val Glu Gly Ala Gln Glu Arg Ala Glu Lys Gly Glu 
145                 150                 155                 160 

Leu Leu Phe Gly Thr Ile Asp Thr Trp Leu Val Trp Lys Leu Thr Asp 
                165                 170                 175     

Gly Ala Ala His Val Thr Asp Tyr Ser Asn Ala Ala Arg Thr Met Leu 
            180                 185                 190         

Tyr Asn Ile Lys Glu Leu Lys Trp Asp Asp Glu Ile Leu Glu Ile Leu 
        195                 200                 205             

Asn Ile Pro Lys Ala Ile Leu Pro Glu Val Arg Ser Asn Ser Glu Ile 
    210                 215                 220                 

Tyr Gly Lys Thr Ala Pro Phe His Phe Tyr Gly Gly Glu Val Pro Ile 
225                 230                 235                 240 

Ser Gly Met Ala Gly Asp Gln Gln Ala Ala Leu Phe Gly Gln Leu Ala 
                245                 250                 255     

Phe Glu Pro Gly Met Val Lys Asn Thr Tyr Gly Thr Gly Ser Phe Ile 
            260                 265                 270         

Ile Met Asn Thr Gly Glu Glu Met Gln Leu Ser Glu Asn Asn Leu Leu 
        275                 280                 285             

Thr Thr Ile Gly Tyr Gly Ile Asn Gly Lys Val Tyr Tyr Ala Leu Glu 
    290                 295                 300                 

Gly Ser Ile Phe Ile Ala Gly Ser Ala Ile Gln Trp Leu Arg Asp Gly 
305                 310                 315                 320 

Leu Arg Met Val Glu Asn Ser Pro Glu Ser Glu Lys Tyr Ala Arg Asp 
                325                 330                 335     

Ser His Asn Asn Asp Glu Val Tyr Val Val Pro Ala Phe Thr Gly Leu 
            340                 345                 350         

Gly Ala Pro Tyr Trp Asn Gln Asn Ala Arg Gly Ser Val Phe Gly Leu 
        355                 360                 365             

Thr Arg Gly Thr Ser Lys Glu Asp Phe Ile Lys Ala Thr Leu Gln Ser 
    370                 375                 380                 

Ile Ala Tyr Gln Val Arg Asp Ile Ile Asp Thr Met Gln Val Asp Thr 
385                 390                 395                 400 

Gln Thr Ala Ile Gln Val Leu Lys Val Asp Gly Gly Ala Ala Met Asn 
                405                 410                 415     

Asn Phe Leu Met Gln Phe Gln Ala Asp Ile Leu Gly Ile Asp Ile Ala 
            420                 425                 430         

Arg Ala Lys Asn Leu Glu Thr Thr Ala Leu Gly Ala Ala Phe Leu Ala 
        435                 440                 445             

Gly Leu Ser Val Gly Tyr Trp Lys Asp Leu Asp Glu Leu Lys Leu Leu 
    450                 455                 460                 

Asn Glu Thr Gly Glu Leu Phe Glu Pro Ser Met Asn Glu Ser Arg Lys 
465                 470                 475                 480 

Glu Gln Leu Tyr Lys Gly Trp Lys Lys Ala Val Lys Ala Thr Gln Val 
                485                 490                 495     

Phe Ala Glu Val Asp Asp 
            500         

<210>   4591
<211>   1425
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4591
atgtatttag gagatttgat ggagaaagcc gagtgtggtc aattttcaat actttccttt   60
ctattacaag agtctcagac gaccgtcaag gctgtaatgg aagaaacagg attttcaaaa   120
gcaaccctaa ccaaatatgt caccctgctc aatgacaagg ctttggatag tggcttagag   180

ctggctattc actcagaaga tgaaaatctg cgtctgtcta tcggtgcagc taccaagggg   240
agagatattc ggagcttgtt tttggagagt gctgttaaat accagatttt ggtttatctt   300
ctctaccacc aacagttttt agcccatcag ctggctcaag aattggtgat tagcgaggct   360
acgcttggtc gtcacttggc tggtttaaat cagattttgt cagaatttga tttatccatc   420
caaaatggcc gttggcgagg tccagagcat cagattcact atttctattt ctgtcttttc   480
cgaaaggtct ggtcgagtca ggaatgggaa ggtcacatgc agaaaccaga gagaaaacag   540
gagattgcca atttagagga aatctgcggt gcaagtttgt ctgcggggca gaaattggac   600
ttggttctct gggctcacat cagtcaacaa cgtcttcggg tcaatgcttg tcagtttcaa   660
gtcatagaag agaaaatgcg agggtatttt gacaatatct tttatcttcg tttgctgaga   720
aaggttccgt ccttttttgc tgggcaacat attccactag gagttgagga tggtgagatg   780
atgatattct tctcttttct cctatctcat cgcattcttc ctcttcatac tatggagtat   840
attcttggtt ttggagggca gttggcagat ttactgacgc aattgattca agaaatgaag   900
aaggaggaac tattggggga ttatacagag gaccatgtca cctatgaact cagtcagctt   960
tgtgctcaag tctatctcta taagggctat attttacagg atcgctacaa gtaccagtta   1020
gagaatcgtc atccatattt actgatggaa catgatttta aagagacagc agaggagatt   1080
tttcatgctc tacctgcttt tcaacagggg acagatttag ataagaagat tctctgggaa   1140
tggctccagt taatcgaata tatggctgaa aacggtggcc agcatatgcg gattggtctg   1200
gatttgacat ctggttttct tgtcttttca aggatggcag ccattttgaa acggtatttg   1260
gaatacaatc gttttattac cattgaagct tatgacccta gtcggcatta tgatttgctg   1320
gttaccaata acccgattca taagaaggaa cagacaccag tctattattt aaaaaatgac   1380
ttggatatgg aggatttggt agcgattcgc cagttattat tcact                   1425

<210>   4592
<211>   475
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: outside
<223>   Feature of note: similar to TeNT
<223>   Similar to strain R6 sequence 15904033 (0.E+01)

<400>   4592
Met Tyr Leu Gly Asp Leu Met Glu Lys Ala Glu Cys Gly Gln Phe Ser 
1               5                   10                  15      

Ile Leu Ser Phe Leu Leu Gln Glu Ser Gln Thr Thr Val Lys Ala Val 
            20                  25                  30          

Met Glu Glu Thr Gly Phe Ser Lys Ala Thr Leu Thr Lys Tyr Val Thr 
        35                  40                  45              

Leu Leu Asn Asp Lys Ala Leu Asp Ser Gly Leu Glu Leu Ala Ile His 
    50                  55                  60                  

Ser Glu Asp Glu Asn Leu Arg Leu Ser Ile Gly Ala Ala Thr Lys Gly 
65                  70                  75                  80  

Arg Asp Ile Arg Ser Leu Phe Leu Glu Ser Ala Val Lys Tyr Gln Ile 
                85                  90                  95      

Leu Val Tyr Leu Leu Tyr His Gln Gln Phe Leu Ala His Gln Leu Ala 
            100                 105                 110         

Gln Glu Leu Val Ile Ser Glu Ala Thr Leu Gly Arg His Leu Ala Gly 
        115                 120                 125             

Leu Asn Gln Ile Leu Ser Glu Phe Asp Leu Ser Ile Gln Asn Gly Arg 
    130                 135                 140                 

Trp Arg Gly Pro Glu His Gln Ile His Tyr Phe Tyr Phe Cys Leu Phe 
145                 150                 155                 160 

Arg Lys Val Trp Ser Ser Gln Glu Trp Glu Gly His Met Gln Lys Pro 
                165                 170                 175     

Glu Arg Lys Gln Glu Ile Ala Asn Leu Glu Glu Ile Cys Gly Ala Ser 
            180                 185                 190         

Leu Ser Ala Gly Gln Lys Leu Asp Leu Val Leu Trp Ala His Ile Ser 
        195                 200                 205             

Gln Gln Arg Leu Arg Val Asn Ala Cys Gln Phe Gln Val Ile Glu Glu 
    210                 215                 220                 

Lys Met Arg Gly Tyr Phe Asp Asn Ile Phe Tyr Leu Arg Leu Leu Arg 
225                 230                 235                 240 

Lys Val Pro Ser Phe Phe Ala Gly Gln His Ile Pro Leu Gly Val Glu 
                245                 250                 255     

Asp Gly Glu Met Met Ile Phe Phe Ser Phe Leu Leu Ser His Arg Ile 
            260                 265                 270         

Leu Pro Leu His Thr Met Glu Tyr Ile Leu Gly Phe Gly Gly Gln Leu 
        275                 280                 285             

Ala Asp Leu Leu Thr Gln Leu Ile Gln Glu Met Lys Lys Glu Glu Leu 
    290                 295                 300                 

Leu Gly Asp Tyr Thr Glu Asp His Val Thr Tyr Glu Leu Ser Gln Leu 
305                 310                 315                 320 

Cys Ala Gln Val Tyr Leu Tyr Lys Gly Tyr Ile Leu Gln Asp Arg Tyr 
                325                 330                 335     

Lys Tyr Gln Leu Glu Asn Arg His Pro Tyr Leu Leu Met Glu His Asp 
            340                 345                 350         

Phe Lys Glu Thr Ala Glu Glu Ile Phe His Ala Leu Pro Ala Phe Gln 
        355                 360                 365             

Gln Gly Thr Asp Leu Asp Lys Lys Ile Leu Trp Glu Trp Leu Gln Leu 
    370                 375                 380                 

Ile Glu Tyr Met Ala Glu Asn Gly Gly Gln His Met Arg Ile Gly Leu 
385                 390                 395                 400 

Asp Leu Thr Ser Gly Phe Leu Val Phe Ser Arg Met Ala Ala Ile Leu 
                405                 410                 415     

Lys Arg Tyr Leu Glu Tyr Asn Arg Phe Ile Thr Ile Glu Ala Tyr Asp 
            420                 425                 430         

Pro Ser Arg His Tyr Asp Leu Leu Val Thr Asn Asn Pro Ile His Lys 
        435                 440                 445             

Lys Glu Gln Thr Pro Val Tyr Tyr Leu Lys Asn Asp Leu Asp Met Glu 
    450                 455                 460                 

Asp Leu Val Ala Ile Arg Gln Leu Leu Phe Thr 
465                 470                 475 

<210>   4593
<211>   870
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4593
atggataaaa ttattaaaac tatatcagaa agcggagcct ttcgtgcttt tgtccttgat   60
agcactgaaa ccgtccgcac tgctcaagaa aaacatcaaa cccaagctag ctcaactgta   120
gcgcttggtc gaactcttat cgctagccag attctcgcag ccaatgaaaa aggaaatacc   180
aaacttacag ttaaggtgtt gggatctagc tctctaggtg ctattatcac cgtcgctgat   240
accaagggga acgtcaaagg ctatgttcaa aatcctggtg ttgacatcaa aaagactgcg   300
actggtgaag tcctagtcgg accttttgtt ggaaatggtc aattcctcgt tatcacagac   360
tacggtactg gaaatcctta caactctata actcccctca tctctggaga aatcggtgaa   420
gaccttgcct tttaccttac tgaaagccaa caaacgcctt cagcggtcgg cctcaatgtc   480
cttttggacg aggaagacaa ggtcaaggtt gcaggtggtt tcctagttca agtcttgcca   540
ggagccaaga aagaagagat tgctcgcttt gaaaaacgca tccaagaaat gccagctatc   600
tctactcttc tcgaaagcga cgaccatatc gaagccctcc tcaaggctat ctacggggac   660
gaagcctaca agcgtctttc tgaagaagaa atccgtttcc aatgtgactg tagccatgaa   720
cgctttatga acgctcttgc cagccttcca agctcagact tacaggaaat gaaagaggaa   780
gaccacgggg cagaaatcac ttgtcaattc tgccaaacta cttacaactt tgatgaaaag   840
gacctggagg aactcattcg tgacaaatct                                    870

<210>   4594
<211>   290
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   chaperonin, 33 kDa (hslO)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904034 (e-163)

<400>   4594
Met Asp Lys Ile Ile Lys Thr Ile Ser Glu Ser Gly Ala Phe Arg Ala 
1               5                   10                  15      

Phe Val Leu Asp Ser Thr Glu Thr Val Arg Thr Ala Gln Glu Lys His 
            20                  25                  30          

Gln Thr Gln Ala Ser Ser Thr Val Ala Leu Gly Arg Thr Leu Ile Ala 
        35                  40                  45              

Ser Gln Ile Leu Ala Ala Asn Glu Lys Gly Asn Thr Lys Leu Thr Val 
    50                  55                  60                  

Lys Val Leu Gly Ser Ser Ser Leu Gly Ala Ile Ile Thr Val Ala Asp 
65                  70                  75                  80  

Thr Lys Gly Asn Val Lys Gly Tyr Val Gln Asn Pro Gly Val Asp Ile 
                85                  90                  95      

Lys Lys Thr Ala Thr Gly Glu Val Leu Val Gly Pro Phe Val Gly Asn 
            100                 105                 110         

Gly Gln Phe Leu Val Ile Thr Asp Tyr Gly Thr Gly Asn Pro Tyr Asn 
        115                 120                 125             

Ser Ile Thr Pro Leu Ile Ser Gly Glu Ile Gly Glu Asp Leu Ala Phe 
    130                 135                 140                 

Tyr Leu Thr Glu Ser Gln Gln Thr Pro Ser Ala Val Gly Leu Asn Val 
145                 150                 155                 160 

Leu Leu Asp Glu Glu Asp Lys Val Lys Val Ala Gly Gly Phe Leu Val 
                165                 170                 175     


Gln Val Leu Pro Gly Ala Lys Lys Glu Glu Ile Ala Arg Phe Glu Lys 
            180                 185                 190         

Arg Ile Gln Glu Met Pro Ala Ile Ser Thr Leu Leu Glu Ser Asp Asp 
        195                 200                 205             

His Ile Glu Ala Leu Leu Lys Ala Ile Tyr Gly Asp Glu Ala Tyr Lys 
    210                 215                 220                 

Arg Leu Ser Glu Glu Glu Ile Arg Phe Gln Cys Asp Cys Ser His Glu 
225                 230                 235                 240 

Arg Phe Met Asn Ala Leu Ala Ser Leu Pro Ser Ser Asp Leu Gln Glu 
                245                 250                 255     

Met Lys Glu Glu Asp His Gly Ala Glu Ile Thr Cys Gln Phe Cys Gln 
            260                 265                 270         

Thr Thr Tyr Asn Phe Asp Glu Lys Asp Leu Glu Glu Leu Ile Arg Asp 
        275                 280                 285             

Lys Ser 
    290 

<210>   4595
<211>   1008
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4595
ttgatgaaaa ggacctggag gaactcattc gtgacaaatc ttaatacacc ttttatgatt   60
ggcaatattg agattcccaa tcgtaccgtt ttagcgccta tggctggcgt gaccaactca   120
gcctttcgta ctatcgcaaa ggagctcgga gctggactcg ttgtaatgga aatggtctct   180
gacaagggaa tccaatacaa caacgaaaaa accctgcaca tgcttcatat cgatgagggc   240
gaaaaccctg tctctatcca actttttggt agcgatgaag acagcctagc acgcgcagca   300
gaattcatcc aagaaaacac caagaccgat atcgtcgata tcaacatggg ctgccctgtc   360
aacaaaatcg tgaagaacga agctggtgct atgtggctca aggatccaga caagatttac   420
tccatcatca acaaggtcca gtctgtcctt gatatcccac ttactgtcaa aatgcgtacc   480
ggctgggcgg acccatctct tgcagtagaa aatgctctcg ctgctgaagc tgcaggtgtt   540
tctgccctcg ccatgcatgg ccgtacccgt gaacaaatgt atactggcca cgcagacctt   600
gagacccttt acaaggttgc ccaagctcta accaagattc cattcatcgc caacggtgat   660
atccgtactg tccaagaagc caagcaacgc atcgaagaag ttggtgctga cgcagtcatg   720
attggccgag ctgccatggg aaatccttac ctcttcaacc aaatcaacca ttactttgaa   780
acaggagaaa tcctacctga tttgaccttt gaagacaaga tgaagatcgc ctacgaacac   840
ttgaaacgat tgattaacct caaaggagaa aacgtcgcag ttcgtgaatt ccgcggtctc   900
gctcctcact atctccgtgg aacatctggc gctgccaaac tccgtggagc catttcgcaa   960
gccagcaccc tggcagagat tgaaaccctc ttgcaattgg agaaggct                1008

<210>   4596
<211>   336
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   TIM-barrel protein, putative, NifR3 family
<223>   Similar to strain R6 sequence 15904035 (e-179)

<400>   4596
Met Met Lys Arg Thr Trp Arg Asn Ser Phe Val Thr Asn Leu Asn Thr 
1               5                   10                  15      

Pro Phe Met Ile Gly Asn Ile Glu Ile Pro Asn Arg Thr Val Leu Ala 
            20                  25                  30          

Pro Met Ala Gly Val Thr Asn Ser Ala Phe Arg Thr Ile Ala Lys Glu 
        35                  40                  45              

Leu Gly Ala Gly Leu Val Val Met Glu Met Val Ser Asp Lys Gly Ile 
    50                  55                  60                  

Gln Tyr Asn Asn Glu Lys Thr Leu His Met Leu His Ile Asp Glu Gly 
65                  70                  75                  80  

Glu Asn Pro Val Ser Ile Gln Leu Phe Gly Ser Asp Glu Asp Ser Leu 
                85                  90                  95      

Ala Arg Ala Ala Glu Phe Ile Gln Glu Asn Thr Lys Thr Asp Ile Val 
            100                 105                 110         

Asp Ile Asn Met Gly Cys Pro Val Asn Lys Ile Val Lys Asn Glu Ala 
        115                 120                 125             

Gly Ala Met Trp Leu Lys Asp Pro Asp Lys Ile Tyr Ser Ile Ile Asn 
    130                 135                 140                 

Lys Val Gln Ser Val Leu Asp Ile Pro Leu Thr Val Lys Met Arg Thr 
145                 150                 155                 160 

Gly Trp Ala Asp Pro Ser Leu Ala Val Glu Asn Ala Leu Ala Ala Glu 
                165                 170                 175     

Ala Ala Gly Val Ser Ala Leu Ala Met His Gly Arg Thr Arg Glu Gln 
            180                 185                 190         

Met Tyr Thr Gly His Ala Asp Leu Glu Thr Leu Tyr Lys Val Ala Gln 
        195                 200                 205             

Ala Leu Thr Lys Ile Pro Phe Ile Ala Asn Gly Asp Ile Arg Thr Val 
    210                 215                 220                 

Gln Glu Ala Lys Gln Arg Ile Glu Glu Val Gly Ala Asp Ala Val Met 
225                 230                 235                 240 

Ile Gly Arg Ala Ala Met Gly Asn Pro Tyr Leu Phe Asn Gln Ile Asn 
                245                 250                 255     

His Tyr Phe Glu Thr Gly Glu Ile Leu Pro Asp Leu Thr Phe Glu Asp 
            260                 265                 270         

Lys Met Lys Ile Ala Tyr Glu His Leu Lys Arg Leu Ile Asn Leu Lys 
        275                 280                 285             

Gly Glu Asn Val Ala Val Arg Glu Phe Arg Gly Leu Ala Pro His Tyr 
    290                 295                 300                 

Leu Arg Gly Thr Ser Gly Ala Ala Lys Leu Arg Gly Ala Ile Ser Gln 
305                 310                 315                 320 

Ala Ser Thr Leu Ala Glu Ile Glu Thr Leu Leu Gln Leu Glu Lys Ala 
                325                 330                 335     


<210>   4597
<211>   2079
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4597
atgtttgcat caaaaagcga aagaaaagta cattattcaa ttcgtaaatt tagtgttgga   60
gtagctagtg tagttgttgc cagtcttgtt atgggaagtg tggttcatgc gacagagaac   120
gagggagcta cccaagtacc cacttcttct aatagggcaa atgaaagtca ggcagaacaa   180
ggagaacaac ctaaaaaact cgattcagaa cgagataagg caaggaaaga ggtcgaggaa   240
tatgtaaaaa aaatagtggg tgagagctat gcaaaatcaa ctaaaaagcg acatacaatt   300
actgtagctc tagttaacga gttgaacaac attaagaacg agtatttgaa taaaatagtt   360
gaatcaacct cagaaagcca actacagata ctgatgatgg agagtcgatc aaaagtagat   420
gaagctgtgt ctaagtttga aaaggactca tcttcttcgt caagttcaga ctcttccact   480
aaaccggaag cttcagatac agcgaagcca aacaagccga cagaaccagg agaaaaggta   540
gcagaagcta agaagaaggt tgaagaagct gagaaaaaag ccaaggatca aaaagaagaa   600
gatcgtcgta actacccaac cattacttac aaaacgcttg aacttgaaat tgctgagtcc   660
gatgtggaag ttaaaaaagc ggagcttgaa ctagtaaaag tgaaagctaa cgaacctcga   720
gacgagcaaa aaattaagca agcagaagcg gaagttgaga gtaaacaagc tgaggctaca   780
aggttaaaaa aaatcaagac agatcgtgaa gaagcagaag aagaagctaa acgaagagca   840
gatgctaaag agcaaggtaa accaaagggg cgggcaaaac gaggagttcc tggagagcta   900
gcaacacctg ataaaaaaga aaatgatgcg aagtcttcag attctagcgt aggtgaagaa   960
actcttccaa gcccatccct gaaaccagaa aaaaaggtag cagaagctga gaagaaggtt   1020
gaagaagcta agaaaaaagc cgaggatcaa aaagaagaag atcgccgtaa ctacccaacc   1080
aatacttaca aaacgcttga acttgaaatt gctgagtccg atgtggaagt taaaaaagcg   1140
gagcttgaac tagtaaaaga ggaagctaag gaacctcgaa acgaggaaaa agttaagcaa   1200
gcaaaagcgg aagttgagag taaaaaagct gaggctacaa ggttagaaaa aatcaagaca   1260
gatcgtaaaa aagcagaaga agaagctaaa cgaaaagcag cagaagaaga taaagttaaa   1320
gaaaaaccag ctgaacaacc acaaccagcg ccggctccaa aagcagaaaa accagctcca   1380
gctccaaaac cagagaatcc agctgaacaa ccaaaagcag aaaaaccagc tgatcaacaa   1440
gctgaagaag actatgctcg tagatcagaa gaagaatata atcgcttgac tcaacagcaa   1500
ccgccaaaaa ctgaaaaacc agcacaacca tctactccaa aaacaggctg gaaacaagaa   1560
aacggtatgt ggtacttcta caatactgat ggttcaatgg cgacaggatg gctccaaaac   1620
aatggctcat ggtactacct caacagcaat ggcgctatgg cgacaggatg gctccaaaac   1680
aatggttcat ggtactatct aaacgctaat ggttcaatgg caacaggatg gctccaaaac   1740
aatggttcat ggtactacct aaacgctaat ggttcaatgg cgacaggatg gctccaatac   1800
aatggctcat ggtactacct aaacgctaat ggttcaatgg cgacaggatg gctccaatac   1860
aatggctcat ggtactacct aaacgctaat ggtgatatgg cgacaggttg ggtgaaagat   1920
ggagatacct ggtactatct tgaagcatca ggtgctatga aagcaagcca atggttcaaa   1980
gtatcagata aatggtacta tgtcaatggc tcaggtgccc ttgcagtcaa cacaactgta   2040
gatggctatg gagtcaatgc caatggtgaa tgggtaaac                          2079

<210>   4598
<211>   693
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline binding protein A (cbpA)
<223>   Cellular location: outside
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15904036 (0.E+01)

<400>   4598
Met Phe Ala Ser Lys Ser Glu Arg Lys Val His Tyr Ser Ile Arg Lys 
1               5                   10                  15      

Phe Ser Val Gly Val Ala Ser Val Val Val Ala Ser Leu Val Met Gly 
            20                  25                  30          

Ser Val Val His Ala Thr Glu Asn Glu Gly Ala Thr Gln Val Pro Thr 
        35                  40                  45              

Ser Ser Asn Arg Ala Asn Glu Ser Gln Ala Glu Gln Gly Glu Gln Pro 
    50                  55                  60                  

Lys Lys Leu Asp Ser Glu Arg Asp Lys Ala Arg Lys Glu Val Glu Glu 
65                  70                  75                  80  

Tyr Val Lys Lys Ile Val Gly Glu Ser Tyr Ala Lys Ser Thr Lys Lys 
                85                  90                  95      

Arg His Thr Ile Thr Val Ala Leu Val Asn Glu Leu Asn Asn Ile Lys 
            100                 105                 110         

Asn Glu Tyr Leu Asn Lys Ile Val Glu Ser Thr Ser Glu Ser Gln Leu 
        115                 120                 125             

Gln Ile Leu Met Met Glu Ser Arg Ser Lys Val Asp Glu Ala Val Ser 
    130                 135                 140                 

Lys Phe Glu Lys Asp Ser Ser Ser Ser Ser Ser Ser Asp Ser Ser Thr 
145                 150                 155                 160 

Lys Pro Glu Ala Ser Asp Thr Ala Lys Pro Asn Lys Pro Thr Glu Pro 
                165                 170                 175     

Gly Glu Lys Val Ala Glu Ala Lys Lys Lys Val Glu Glu Ala Glu Lys 
            180                 185                 190         

Lys Ala Lys Asp Gln Lys Glu Glu Asp Arg Arg Asn Tyr Pro Thr Ile 
        195                 200                 205             

Thr Tyr Lys Thr Leu Glu Leu Glu Ile Ala Glu Ser Asp Val Glu Val 
    210                 215                 220                 

Lys Lys Ala Glu Leu Glu Leu Val Lys Val Lys Ala Asn Glu Pro Arg 
225                 230                 235                 240 

Asp Glu Gln Lys Ile Lys Gln Ala Glu Ala Glu Val Glu Ser Lys Gln 
                245                 250                 255     

Ala Glu Ala Thr Arg Leu Lys Lys Ile Lys Thr Asp Arg Glu Glu Ala 
            260                 265                 270         

Glu Glu Glu Ala Lys Arg Arg Ala Asp Ala Lys Glu Gln Gly Lys Pro 
        275                 280                 285             

Lys Gly Arg Ala Lys Arg Gly Val Pro Gly Glu Leu Ala Thr Pro Asp 
    290                 295                 300                 

Lys Lys Glu Asn Asp Ala Lys Ser Ser Asp Ser Ser Val Gly Glu Glu 
305                 310                 315                 320 

Thr Leu Pro Ser Pro Ser Leu Lys Pro Glu Lys Lys Val Ala Glu Ala 
                325                 330                 335     

Glu Lys Lys Val Glu Glu Ala Lys Lys Lys Ala Glu Asp Gln Lys Glu 
            340                 345                 350         

Glu Asp Arg Arg Asn Tyr Pro Thr Asn Thr Tyr Lys Thr Leu Glu Leu 
        355                 360                 365             

Glu Ile Ala Glu Ser Asp Val Glu Val Lys Lys Ala Glu Leu Glu Leu 
    370                 375                 380                 

Val Lys Glu Glu Ala Lys Glu Pro Arg Asn Glu Glu Lys Val Lys Gln 
385                 390                 395                 400 

Ala Lys Ala Glu Val Glu Ser Lys Lys Ala Glu Ala Thr Arg Leu Glu 
                405                 410                 415     

Lys Ile Lys Thr Asp Arg Lys Lys Ala Glu Glu Glu Ala Lys Arg Lys 
            420                 425                 430         

Ala Ala Glu Glu Asp Lys Val Lys Glu Lys Pro Ala Glu Gln Pro Gln 
        435                 440                 445             

Pro Ala Pro Ala Pro Lys Ala Glu Lys Pro Ala Pro Ala Pro Lys Pro 
    450                 455                 460                 

Glu Asn Pro Ala Glu Gln Pro Lys Ala Glu Lys Pro Ala Asp Gln Gln 
465                 470                 475                 480 

Ala Glu Glu Asp Tyr Ala Arg Arg Ser Glu Glu Glu Tyr Asn Arg Leu 
                485                 490                 495     

Thr Gln Gln Gln Pro Pro Lys Thr Glu Lys Pro Ala Gln Pro Ser Thr 
            500                 505                 510         

Pro Lys Thr Gly Trp Lys Gln Glu Asn Gly Met Trp Tyr Phe Tyr Asn 
        515                 520                 525             

Thr Asp Gly Ser Met Ala Thr Gly Trp Leu Gln Asn Asn Gly Ser Trp 
    530                 535                 540                 

Tyr Tyr Leu Asn Ser Asn Gly Ala Met Ala Thr Gly Trp Leu Gln Asn 
545                 550                 555                 560 

Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser Met Ala Thr Gly 
                565                 570                 575     

Trp Leu Gln Asn Asn Gly Ser Trp Tyr Tyr Leu Asn Ala Asn Gly Ser 
            580                 585                 590         

Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp Tyr Tyr Leu Asn 
        595                 600                 605             

Ala Asn Gly Ser Met Ala Thr Gly Trp Leu Gln Tyr Asn Gly Ser Trp 
    610                 615                 620                 

Tyr Tyr Leu Asn Ala Asn Gly Asp Met Ala Thr Gly Trp Val Lys Asp 
625                 630                 635                 640 

Gly Asp Thr Trp Tyr Tyr Leu Glu Ala Ser Gly Ala Met Lys Ala Ser 
                645                 650                 655     

Gln Trp Phe Lys Val Ser Asp Lys Trp Tyr Tyr Val Asn Gly Ser Gly 
            660                 665                 670         

Ala Leu Ala Val Asn Thr Thr Val Asp Gly Tyr Gly Val Asn Ala Asn 
        675                 680                 685             

Gly Glu Trp Val Asn 
    690             

<210>   4599
<211>   525
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4599
atggtattag cgattatttt agtaacattc tttattcgat tgattttttt aaagcgttcg   60
atagagaatg agaaacgaat ccttagcaat ggcgggaaag aatttggagt tgagaataca   120
aaacgattaa ctatggctca tattgttttt tatctctctt gcttggttga ggcaatggtg   180
cacaagacaa tttttgatgg catgggcatg gttggtttag tcttgcttat tttttctatg   240
ctgatgttga tgttggtgat tcacttgttg ggagatattt ggacagtgaa gcttatgctt   300
gtcaataatc acaaatatgt agatcatatc ttgtttagga cagtaaaaca ccctaattac   360
tttttaaata ttcttcctga gttgattggc ttgaccttgt tgagtcatgc ttatgtgact   420
tttgttttag tttttccagt ttatgcagtt attttgtatc gacgaatagc tgaagaggaa   480
aagctattac atgaagttat aatcccaaat ggaagcataa agaga                   525

<210>   4600
<211>   175
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904037 (2.E-96)

<400>   4600
Met Val Leu Ala Ile Ile Leu Val Thr Phe Phe Ile Arg Leu Ile Phe 
1               5                   10                  15      

Leu Lys Arg Ser Ile Glu Asn Glu Lys Arg Ile Leu Ser Asn Gly Gly 
            20                  25                  30          

Lys Glu Phe Gly Val Glu Asn Thr Lys Arg Leu Thr Met Ala His Ile 
        35                  40                  45              

Val Phe Tyr Leu Ser Cys Leu Val Glu Ala Met Val His Lys Thr Ile 
    50                  55                  60                  

Phe Asp Gly Met Gly Met Val Gly Leu Val Leu Leu Ile Phe Ser Met 
65                  70                  75                  80  

Leu Met Leu Met Leu Val Ile His Leu Leu Gly Asp Ile Trp Thr Val 
                85                  90                  95      

Lys Leu Met Leu Val Asn Asn His Lys Tyr Val Asp His Ile Leu Phe 
            100                 105                 110         

Arg Thr Val Lys His Pro Asn Tyr Phe Leu Asn Ile Leu Pro Glu Leu 
        115                 120                 125             

Ile Gly Leu Thr Leu Leu Ser His Ala Tyr Val Thr Phe Val Leu Val 
    130                 135                 140                 

Phe Pro Val Tyr Ala Val Ile Leu Tyr Arg Arg Ile Ala Glu Glu Glu 
145                 150                 155                 160 

Lys Leu Leu His Glu Val Ile Ile Pro Asn Gly Ser Ile Lys Arg 
                165                 170                 175 

<210>   4601
<211>   1329
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4601
atgataaaaa atcctaaatt attaaccaag tcttttttaa gaagttttgc aattctaggt   60
ggtgttggtc tagtcattca tatagctatt tatttgacct ttccttttta ttatattcaa   120
ctggaggggg aaaagtttaa tgagagcgca agagtgttta cggagtattt aaagactaag   180
acatctgatg aaattccaag cttactccag tcttattcaa agtccttgac catatctgct   240
caccttaaaa gagatattgt agataagcgg ctccctcttg tgcatgactt ggatattaaa   300
gatggaaagc tatcaaatta tatcgtgatg ttagatatgt ctgttagtac agcagatggt   360
aaacaggtaa ccgtgcaatt tgttcacggg gtggatgtct acaaagaagc aaagaatatt   420
ttgcttttgt atctcccata tacatttttg gttacaattg ctttttcctt tgttttttct   480
tatttttata ctaaacgctt gctcaatcct cttttttaca tttcagaagt gactagtaaa   540
atgcaagatt tggatgacaa tattcgtttt gatgaaagta ggaaagatga agttggtgaa   600
gttggaaaac agattaatgg tatgtatgag cacttgttga aggttattta tgagttggaa   660
agtcgtaatg agcaaattgt aaaattgcaa aatcaaaagg tttcctttgt ccgcggagca   720
tcacatgagt tgaaaacccc tttagccagt cttagaatta tcctagagaa tatgcagcat   780
aatattggag attacaaaga tcatccaaaa tatattgcaa agagtataaa taagattgac   840
cagatgagcc acttattaga agaagtactg gagtcttcta aattccaaga gtggacagag   900
tgtcgtgaga ccttgactgt taagccagtt ttagtagata ttttatcacg ttatcaagaa   960
ttagctcatt caataggtgt tacaattgaa aatcaattga cagatgctac cagggtcgtc   1020
atgagtctta gggcattgga taaggttttg acaaacctga ttagtaatgc aattaaatat   1080
tcagataaaa atgggcgtgt aatcatatcc gagcaagatg gctatctctc tatcaaaaat   1140
acatgtgcgc ctctaagtga ccaagaacta gaacatttat ttgatatatt ctatcattct   1200
caaatcgtga cagataagga tgaaagttcc ggtttgggtc tttacattgt gaataatatt   1260
ttagaaagct atcaaatgga ttatagtttt ctcccttatg aacacggtat ggaatttaag   1320
attagcttg                                                           1329

<210>   4602
<211>   443
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904038 (0.E+01)

<400>   4602
Met Ile Lys Asn Pro Lys Leu Leu Thr Lys Ser Phe Leu Arg Ser Phe 
1               5                   10                  15      

Ala Ile Leu Gly Gly Val Gly Leu Val Ile His Ile Ala Ile Tyr Leu 
            20                  25                  30          

Thr Phe Pro Phe Tyr Tyr Ile Gln Leu Glu Gly Glu Lys Phe Asn Glu 
        35                  40                  45              

Ser Ala Arg Val Phe Thr Glu Tyr Leu Lys Thr Lys Thr Ser Asp Glu 
    50                  55                  60                  

Ile Pro Ser Leu Leu Gln Ser Tyr Ser Lys Ser Leu Thr Ile Ser Ala 
65                  70                  75                  80  

His Leu Lys Arg Asp Ile Val Asp Lys Arg Leu Pro Leu Val His Asp 
                85                  90                  95      

Leu Asp Ile Lys Asp Gly Lys Leu Ser Asn Tyr Ile Val Met Leu Asp 
            100                 105                 110         

Met Ser Val Ser Thr Ala Asp Gly Lys Gln Val Thr Val Gln Phe Val 
        115                 120                 125             

His Gly Val Asp Val Tyr Lys Glu Ala Lys Asn Ile Leu Leu Leu Tyr 
    130                 135                 140                 

Leu Pro Tyr Thr Phe Leu Val Thr Ile Ala Phe Ser Phe Val Phe Ser 
145                 150                 155                 160 

Tyr Phe Tyr Thr Lys Arg Leu Leu Asn Pro Leu Phe Tyr Ile Ser Glu 
                165                 170                 175     

Val Thr Ser Lys Met Gln Asp Leu Asp Asp Asn Ile Arg Phe Asp Glu 
            180                 185                 190         

Ser Arg Lys Asp Glu Val Gly Glu Val Gly Lys Gln Ile Asn Gly Met 
        195                 200                 205             

Tyr Glu His Leu Leu Lys Val Ile Tyr Glu Leu Glu Ser Arg Asn Glu 
    210                 215                 220                 

Gln Ile Val Lys Leu Gln Asn Gln Lys Val Ser Phe Val Arg Gly Ala 
225                 230                 235                 240 

Ser His Glu Leu Lys Thr Pro Leu Ala Ser Leu Arg Ile Ile Leu Glu 
                245                 250                 255     

Asn Met Gln His Asn Ile Gly Asp Tyr Lys Asp His Pro Lys Tyr Ile 
            260                 265                 270         

Ala Lys Ser Ile Asn Lys Ile Asp Gln Met Ser His Leu Leu Glu Glu 
        275                 280                 285             

Val Leu Glu Ser Ser Lys Phe Gln Glu Trp Thr Glu Cys Arg Glu Thr 
    290                 295                 300                 

Leu Thr Val Lys Pro Val Leu Val Asp Ile Leu Ser Arg Tyr Gln Glu 
305                 310                 315                 320 

Leu Ala His Ser Ile Gly Val Thr Ile Glu Asn Gln Leu Thr Asp Ala 
                325                 330                 335     

Thr Arg Val Val Met Ser Leu Arg Ala Leu Asp Lys Val Leu Thr Asn 
            340                 345                 350         

Leu Ile Ser Asn Ala Ile Lys Tyr Ser Asp Lys Asn Gly Arg Val Ile 
        355                 360                 365             

Ile Ser Glu Gln Asp Gly Tyr Leu Ser Ile Lys Asn Thr Cys Ala Pro 
    370                 375                 380                 

Leu Ser Asp Gln Glu Leu Glu His Leu Phe Asp Ile Phe Tyr His Ser 
385                 390                 395                 400 

Gln Ile Val Thr Asp Lys Asp Glu Ser Ser Gly Leu Gly Leu Tyr Ile 
                405                 410                 415     

Val Asn Asn Ile Leu Glu Ser Tyr Gln Met Asp Tyr Ser Phe Leu Pro 
            420                 425                 430         

Tyr Glu His Gly Met Glu Phe Lys Ile Ser Leu 
        435                 440             

<210>   4603
<211>   651
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4603
atgaacattt tagttgcaga tgacgaggaa atgattagag aaggaattgc agcatttctg   60
acagaagagg gttatcatgt cattatggct aaggatggac aagaggtctt ggaaaaattt   120
caagatctcc ctatccatct catggtactg gatttaatga tgcctaggaa gagtggtttt   180
gaagtgttaa aagaaatcaa tcaaaagcac gatattcctg tcatcgtctt gagtgctctg   240
ggagatgaaa ctactcagtc acaggtattt gatctctatg ctgatgatca tgtgacaaaa   300
cctttttctt tggtactgct tgtcaagcgt attaaggcgc ttatcagacg ttactacgtc   360
atagaggatc tttggcgata tcaggatgta acagtggatt ttacctctta caaagcacat   420
tataaaaatg aagaaattga tctcaaacca aaggaattac tggtactaaa gtgtttgatt   480
cagcataaaa atcaagtttt aagtagagag cagatattgg aagaaatttc aaaagatgta   540
gctgatttac cttgtgatag ggtcgttgat gtctatattc gtactcttcg caaaaaatta   600
gctttagatt gtatcgtgac tgtgaaaaat gttgggtata agattagctt a            651

<210>   4604
<211>   217
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904039 (e-121)

<400>   4604
Met Asn Ile Leu Val Ala Asp Asp Glu Glu Met Ile Arg Glu Gly Ile 
1               5                   10                  15      

Ala Ala Phe Leu Thr Glu Glu Gly Tyr His Val Ile Met Ala Lys Asp 
            20                  25                  30          

Gly Gln Glu Val Leu Glu Lys Phe Gln Asp Leu Pro Ile His Leu Met 
        35                  40                  45              

Val Leu Asp Leu Met Met Pro Arg Lys Ser Gly Phe Glu Val Leu Lys 
    50                  55                  60                  

Glu Ile Asn Gln Lys His Asp Ile Pro Val Ile Val Leu Ser Ala Leu 
65                  70                  75                  80  

Gly Asp Glu Thr Thr Gln Ser Gln Val Phe Asp Leu Tyr Ala Asp Asp 
                85                  90                  95      

His Val Thr Lys Pro Phe Ser Leu Val Leu Leu Val Lys Arg Ile Lys 
            100                 105                 110         

Ala Leu Ile Arg Arg Tyr Tyr Val Ile Glu Asp Leu Trp Arg Tyr Gln 
        115                 120                 125             

Asp Val Thr Val Asp Phe Thr Ser Tyr Lys Ala His Tyr Lys Asn Glu 
    130                 135                 140                 

Glu Ile Asp Leu Lys Pro Lys Glu Leu Leu Val Leu Lys Cys Leu Ile 
145                 150                 155                 160 

Gln His Lys Asn Gln Val Leu Ser Arg Glu Gln Ile Leu Glu Glu Ile 
                165                 170                 175     

Ser Lys Asp Val Ala Asp Leu Pro Cys Asp Arg Val Val Asp Val Tyr 
            180                 185                 190         

Ile Arg Thr Leu Arg Lys Lys Leu Ala Leu Asp Cys Ile Val Thr Val 
        195                 200                 205             

Lys Asn Val Gly Tyr Lys Ile Ser Leu 
    210                 215         

<210>   4605
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4605
atgatgaaaa ccacggatcg tttagaagct ataggtttta gtttcatact cttcgaaaat   60
ctcttcaaac cacgtcagct ctatctgcaa cctcaaacca gtgttttgag caacctgcgg   120
ctagctgcc                                                           129

<210>   4606
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4606
Met Met Lys Thr Thr Asp Arg Leu Glu Ala Ile Gly Phe Ser Phe Ile 
1               5                   10                  15      

Leu Phe Glu Asn Leu Phe Lys Pro Arg Gln Leu Tyr Leu Gln Pro Gln 
            20                  25                  30          

Thr Ser Val Leu Ser Asn Leu Arg Leu Ala Ala 
        35                  40              

<210>   4607
<211>   2430
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4607
atgaactatt caaaagcatt gaatgaatgt atcgaaagtg cctacatggt tgctggacat   60
tttggagctc gttatctaga gtcgtggcac ttgttgattg ccatgtctaa tcacagttat   120
agtgtagcag gggcaacttt aaatgattat ccgtatgaga tggaccgttt agaagaggtg   180
gctttggaac tgactgaaac ggactatagc caggatgaaa cctttacgga attgccgttc   240
tcccgtcgtt tgcaggttct ttttgatgaa gcagagtatg tagcgtcagt ggtccatgct   300
aaggtactag ggacagagca cgtcctctat gcgattttgc atgatagcaa tgccttggcg   360
actcgtatct tggagagggc tggtttttct tatgaagaca agaaagatca ggtcaagatt   420
gctgctcttc gtcgaaattt agaagaacgg gcaggctgga ctcgtgaaga tctcaaggct   480
ttacgccaac gccatcgtac agtagctgac aagcaaaatt ctatggccaa tatgatgggc   540
atgccgcaga ctcctagtgg tggtctcgag gattatacgc atgatttgac agagcaagcg   600
cgttctggca agttagaacc agtcatcggt cgggacaagg aaatctcacg tatgattcaa   660
atcttgagcc ggaagactaa gaacaaccct gtcttggttg gggatgctgg tgtcgggaaa   720
acagctctgg cgcttggtct tgcccagcgt attgctagtg gtgacgtgcc tgcggaaatg   780
gctaagatgc gcgtgttaga acttgatttg atgaatgtcg ttgcagggac acgcttccgt   840
ggtgactttg aagaacgcat gaataatatc atcaaggata ttgaagaaga tggccaagtc   900
atcctcttta tcgatgaact ccacaccatc atgggttctg gtagcgggat tgattcgact   960
ctggatgcgg ccaatatctt gaaaccagcc ttggcgcgtg gaactttgag aacggttggt   1020
gccactactc aggaagaata tcaaaaacat atcgaaaaag atgcggcact ttctcgtcgt   1080
ttcgctaaag tgacgattga agaaccaagt gtggcagata gtatgactat tttacaaggt   1140
ttgaaggcga cttatgagaa acatcaccgt gtacaaatca cagatgaagc ggttgaaaca   1200
gcggttaaga tggctcatcg ttatttaacc agtcgtcact tgccagactc tgctatcgat   1260
ctcttggatg aggcggcagc aacagtgcaa aataaggcaa agcatgtaaa agcagacgat   1320
tcagatttga gtccagctga caaggccctg atggatggca agtggaaaca ggcagcccag   1380
ctaatcgcaa aagaagagga agtacctgtc tacaaagact tggtgacaga gtctgatatt   1440
ttgaccacct tgagtcgctt gtcaggaatc ccagttcaaa aactgactca aacggatgct   1500
aagaagtatt taaatcttga agcagaactc cataaacggg ttatcggtca agatcaagct   1560
gtttcaagca ttagccgtgc cattcgccgc aaccagtcag ggattcgcag tcataagcgt   1620
ccgattggtt cctttatgtt cctagggcct acaggtgtcg ggaaaactga attagccaag   1680
gctctggcag aagttctttt tgacgacgaa tcagccctta tccgctttga tatgagtgag   1740
tatatggaga aatttgcagc tagtcgtctc aacggagctc ctccaggcta tgtaggatat   1800
gaagaaggtg gggagttgac agagaaggtt cgcaataaac cctattccgt tctcctcttt   1860
gatgaggtag agaaggccca cccagatatc tttaatgttc tcttgcaggt tctggatgac   1920
ggtgtcttga cagatagcaa gggacgcaag gtcgattttt caaataccat tatcattatg   1980
acatcgaatc taggtgcgac tgcccttcgt gatgataaga ctgttggttt tggggctaag   2040
gatattcgtt ttgaccagga aaatatggaa aaacgcatgt ttgaagaact gaaaaaagct   2100
tatagaccgg aattcatcaa ccgtattgat gagaaggtgg tcttccatag cctatctagt   2160
gatcatatgc aggaagtggt gaagattatg gtcaagcctt tagtggcaag tttgactgaa   2220
aaaggcattg acttgaaatt acaagcttca gctctgaaat tgttagcaaa tcaaggatat   2280
gacccagaga tgggagctcg cccacttcgc agaaccctgc aaacagaagt ggaggacaag   2340
ttggcagaac ttcttctcaa gggagattta gtggcaggca gcacacttaa gattggtgtc   2400
aaagcaggcc agttaaaatt tgatattgca                                    2430

<210>   4608
<211>   810
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ATP-dependent Clp protease, ATP-binding subunit
<223>   Cellular location: cytoplasm
<223>   Feature of note: RGD motif
<223>   Similar to strain R6 sequence 15904041 (0.E+01)

<400>   4608
Met Asn Tyr Ser Lys Ala Leu Asn Glu Cys Ile Glu Ser Ala Tyr Met 
1               5                   10                  15      

Val Ala Gly His Phe Gly Ala Arg Tyr Leu Glu Ser Trp His Leu Leu 
            20                  25                  30          

Ile Ala Met Ser Asn His Ser Tyr Ser Val Ala Gly Ala Thr Leu Asn 
        35                  40                  45              

Asp Tyr Pro Tyr Glu Met Asp Arg Leu Glu Glu Val Ala Leu Glu Leu 
    50                  55                  60                  

Thr Glu Thr Asp Tyr Ser Gln Asp Glu Thr Phe Thr Glu Leu Pro Phe 
65                  70                  75                  80  

Ser Arg Arg Leu Gln Val Leu Phe Asp Glu Ala Glu Tyr Val Ala Ser 
                85                  90                  95      

Val Val His Ala Lys Val Leu Gly Thr Glu His Val Leu Tyr Ala Ile 
            100                 105                 110         

Leu His Asp Ser Asn Ala Leu Ala Thr Arg Ile Leu Glu Arg Ala Gly 
        115                 120                 125             

Phe Ser Tyr Glu Asp Lys Lys Asp Gln Val Lys Ile Ala Ala Leu Arg 
    130                 135                 140                 

Arg Asn Leu Glu Glu Arg Ala Gly Trp Thr Arg Glu Asp Leu Lys Ala 
145                 150                 155                 160 

Leu Arg Gln Arg His Arg Thr Val Ala Asp Lys Gln Asn Ser Met Ala 
                165                 170                 175     

Asn Met Met Gly Met Pro Gln Thr Pro Ser Gly Gly Leu Glu Asp Tyr 
            180                 185                 190         

Thr His Asp Leu Thr Glu Gln Ala Arg Ser Gly Lys Leu Glu Pro Val 
        195                 200                 205             

Ile Gly Arg Asp Lys Glu Ile Ser Arg Met Ile Gln Ile Leu Ser Arg 
    210                 215                 220                 

Lys Thr Lys Asn Asn Pro Val Leu Val Gly Asp Ala Gly Val Gly Lys 
225                 230                 235                 240 

Thr Ala Leu Ala Leu Gly Leu Ala Gln Arg Ile Ala Ser Gly Asp Val 
                245                 250                 255     

Pro Ala Glu Met Ala Lys Met Arg Val Leu Glu Leu Asp Leu Met Asn 
            260                 265                 270         

Val Val Ala Gly Thr Arg Phe Arg Gly Asp Phe Glu Glu Arg Met Asn 
        275                 280                 285             

Asn Ile Ile Lys Asp Ile Glu Glu Asp Gly Gln Val Ile Leu Phe Ile 
    290                 295                 300                 

Asp Glu Leu His Thr Ile Met Gly Ser Gly Ser Gly Ile Asp Ser Thr 
305                 310                 315                 320 

Leu Asp Ala Ala Asn Ile Leu Lys Pro Ala Leu Ala Arg Gly Thr Leu 
                325                 330                 335     

Arg Thr Val Gly Ala Thr Thr Gln Glu Glu Tyr Gln Lys His Ile Glu 
            340                 345                 350         

Lys Asp Ala Ala Leu Ser Arg Arg Phe Ala Lys Val Thr Ile Glu Glu 
        355                 360                 365             

Pro Ser Val Ala Asp Ser Met Thr Ile Leu Gln Gly Leu Lys Ala Thr 
    370                 375                 380                 

Tyr Glu Lys His His Arg Val Gln Ile Thr Asp Glu Ala Val Glu Thr 
385                 390                 395                 400 

Ala Val Lys Met Ala His Arg Tyr Leu Thr Ser Arg His Leu Pro Asp 
                405                 410                 415     

Ser Ala Ile Asp Leu Leu Asp Glu Ala Ala Ala Thr Val Gln Asn Lys 
            420                 425                 430         

Ala Lys His Val Lys Ala Asp Asp Ser Asp Leu Ser Pro Ala Asp Lys 
        435                 440                 445             

Ala Leu Met Asp Gly Lys Trp Lys Gln Ala Ala Gln Leu Ile Ala Lys 
    450                 455                 460                 

Glu Glu Glu Val Pro Val Tyr Lys Asp Leu Val Thr Glu Ser Asp Ile 
465                 470                 475                 480 

Leu Thr Thr Leu Ser Arg Leu Ser Gly Ile Pro Val Gln Lys Leu Thr 
                485                 490                 495     

Gln Thr Asp Ala Lys Lys Tyr Leu Asn Leu Glu Ala Glu Leu His Lys 
            500                 505                 510         

Arg Val Ile Gly Gln Asp Gln Ala Val Ser Ser Ile Ser Arg Ala Ile 
        515                 520                 525             

Arg Arg Asn Gln Ser Gly Ile Arg Ser His Lys Arg Pro Ile Gly Ser 
    530                 535                 540                 

Phe Met Phe Leu Gly Pro Thr Gly Val Gly Lys Thr Glu Leu Ala Lys 
545                 550                 555                 560 

Ala Leu Ala Glu Val Leu Phe Asp Asp Glu Ser Ala Leu Ile Arg Phe 
                565                 570                 575     

Asp Met Ser Glu Tyr Met Glu Lys Phe Ala Ala Ser Arg Leu Asn Gly 
            580                 585                 590         

Ala Pro Pro Gly Tyr Val Gly Tyr Glu Glu Gly Gly Glu Leu Thr Glu 
        595                 600                 605             

Lys Val Arg Asn Lys Pro Tyr Ser Val Leu Leu Phe Asp Glu Val Glu 
    610                 615                 620                 

Lys Ala His Pro Asp Ile Phe Asn Val Leu Leu Gln Val Leu Asp Asp 
625                 630                 635                 640 

Gly Val Leu Thr Asp Ser Lys Gly Arg Lys Val Asp Phe Ser Asn Thr 
                645                 650                 655     

Ile Ile Ile Met Thr Ser Asn Leu Gly Ala Thr Ala Leu Arg Asp Asp 
            660                 665                 670         

Lys Thr Val Gly Phe Gly Ala Lys Asp Ile Arg Phe Asp Gln Glu Asn 
        675                 680                 685             

Met Glu Lys Arg Met Phe Glu Glu Leu Lys Lys Ala Tyr Arg Pro Glu 
    690                 695                 700                 

Phe Ile Asn Arg Ile Asp Glu Lys Val Val Phe His Ser Leu Ser Ser 
705                 710                 715                 720 

Asp His Met Gln Glu Val Val Lys Ile Met Val Lys Pro Leu Val Ala 
                725                 730                 735     

Ser Leu Thr Glu Lys Gly Ile Asp Leu Lys Leu Gln Ala Ser Ala Leu 
            740                 745                 750         

Lys Leu Leu Ala Asn Gln Gly Tyr Asp Pro Glu Met Gly Ala Arg Pro 
        755                 760                 765             

Leu Arg Arg Thr Leu Gln Thr Glu Val Glu Asp Lys Leu Ala Glu Leu 
    770                 775                 780                 

Leu Leu Lys Gly Asp Leu Val Ala Gly Ser Thr Leu Lys Ile Gly Val 
785                 790                 795                 800 

Lys Ala Gly Gln Leu Lys Phe Asp Ile Ala 
                805                 810 

<210>   4609
<211>   456
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4609
atgagattta aaaatacatc ggatcatatt gaggcctaca tcaaggcgat tttagatcaa   60
tctggtatcg tggagttgca acggagtcag ttggcagata cctttcaggt tgttcctagt   120
cagattaact acgtgatcaa gacacgcttt acggaaagta gaggctactt ggttgaaagt   180
aagcgtggtg gcggaggcta cattcgtata ggacggattg agttttctag tcatcatgaa   240
atgctccggg agctgcttta ctcgattggt gagcgagtca gtcaagaaat ttatgaggat   300
attctccagc ttttggttga gcaggaattg atgaccaagc aggagatgaa tttgctagaa   360
tcagtagctt tggatcgcgt tttaggagaa gaagctccag ttgttcgagc aaacatgcta   420
cgtcagatca tacaagaggt agatagaaaa gggaag                             456

<210>   4610
<211>   152
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator CtsR (ctsR)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904042 (2.E-80)

<400>   4610
Met Arg Phe Lys Asn Thr Ser Asp His Ile Glu Ala Tyr Ile Lys Ala 
1               5                   10                  15      

Ile Leu Asp Gln Ser Gly Ile Val Glu Leu Gln Arg Ser Gln Leu Ala 
            20                  25                  30          

Asp Thr Phe Gln Val Val Pro Ser Gln Ile Asn Tyr Val Ile Lys Thr 
        35                  40                  45              

Arg Phe Thr Glu Ser Arg Gly Tyr Leu Val Glu Ser Lys Arg Gly Gly 
    50                  55                  60                  

Gly Gly Tyr Ile Arg Ile Gly Arg Ile Glu Phe Ser Ser His His Glu 
65                  70                  75                  80  

Met Leu Arg Glu Leu Leu Tyr Ser Ile Gly Glu Arg Val Ser Gln Glu 
                85                  90                  95      

Ile Tyr Glu Asp Ile Leu Gln Leu Leu Val Glu Gln Glu Leu Met Thr 
            100                 105                 110         

Lys Gln Glu Met Asn Leu Leu Glu Ser Val Ala Leu Asp Arg Val Leu 
        115                 120                 125             

Gly Glu Glu Ala Pro Val Val Arg Ala Asn Met Leu Arg Gln Ile Ile 
    130                 135                 140                 

Gln Glu Val Asp Arg Lys Gly Lys 
145                 150         

<210>   4611
<211>   726
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4611
atgacagaaa ttagactaga gcacgtcagt tatgcctatg gtcaggagag gattttagag   60
gatatcaacc tacaggtgac ttcaggcgaa gtggtttcca tcctaggccc aagtggtgtt   120
ggaaagacca ccctctttaa tctaatcgct gggattttag aagttcagtc agggagaatt   180
gtccttgatg gtgaagaaaa tcccaagggg cgcgtgagtt atatgttgca aaaggatctg   240
ctcttggagc acaagacggt gcttggaaat atcattctgc ccctcttgat tcaaaaggtg   300
gataaggcag aagctatttc ccgagcggat aaaattcttg cgaccttcca gctgacagct   360
gtaagagaca agtatcctca tgaacttagc ggtgggatgc gccagcgtgt agccttactc   420
cggacctacc tttttgggca caagctcttt ctcttagatg aggcctttag cgccttggat   480
gagatgacaa agatggaact ccacgcttgg tatcttgaga ttcacaagca gttgcagcta   540
acaaccctga tcatcacgca tagtattgag gaggccctca atctcagcga ccgtatctat   600
atcttgaaaa atcgccctgg gcagattgtt tcagaaatta aactagattg gtctgaagat   660
gaggacaagg aagtccaaaa gattgcctac aaacgtcaaa ttttggcgga attaggctta   720
gataag                                                              726

<210>   4612
<211>   242
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904043 (e-134)

<400>   4612
Met Thr Glu Ile Arg Leu Glu His Val Ser Tyr Ala Tyr Gly Gln Glu 
1               5                   10                  15      

Arg Ile Leu Glu Asp Ile Asn Leu Gln Val Thr Ser Gly Glu Val Val 
            20                  25                  30          

Ser Ile Leu Gly Pro Ser Gly Val Gly Lys Thr Thr Leu Phe Asn Leu 
        35                  40                  45              

Ile Ala Gly Ile Leu Glu Val Gln Ser Gly Arg Ile Val Leu Asp Gly 
    50                  55                  60                  

Glu Glu Asn Pro Lys Gly Arg Val Ser Tyr Met Leu Gln Lys Asp Leu 
65                  70                  75                  80  

Leu Leu Glu His Lys Thr Val Leu Gly Asn Ile Ile Leu Pro Leu Leu 
                85                  90                  95      

Ile Gln Lys Val Asp Lys Ala Glu Ala Ile Ser Arg Ala Asp Lys Ile 
            100                 105                 110         

Leu Ala Thr Phe Gln Leu Thr Ala Val Arg Asp Lys Tyr Pro His Glu 
        115                 120                 125             

Leu Ser Gly Gly Met Arg Gln Arg Val Ala Leu Leu Arg Thr Tyr Leu 
    130                 135                 140                 

Phe Gly His Lys Leu Phe Leu Leu Asp Glu Ala Phe Ser Ala Leu Asp 
145                 150                 155                 160 

Glu Met Thr Lys Met Glu Leu His Ala Trp Tyr Leu Glu Ile His Lys 
                165                 170                 175     

Gln Leu Gln Leu Thr Thr Leu Ile Ile Thr His Ser Ile Glu Glu Ala 
            180                 185                 190         

Leu Asn Leu Ser Asp Arg Ile Tyr Ile Leu Lys Asn Arg Pro Gly Gln 
        195                 200                 205             

Ile Val Ser Glu Ile Lys Leu Asp Trp Ser Glu Asp Glu Asp Lys Glu 
    210                 215                 220                 

Val Gln Lys Ile Ala Tyr Lys Arg Gln Ile Leu Ala Glu Leu Gly Leu 
225                 230                 235                 240 

Asp Lys 
        

<210>   4613
<211>   1005
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4613
atgaagaaaa catggaaagt gtttttaacg cttgtaacag ctcttgtagc tgttgtgctt   60
gtggcctgtg gtcaaggaac tgcttctaaa gacaacaaag aggcagaact taagaaggtt   120
gactttatcc tagactggac accaaatacc aaccacacag ggctttatgt tgccaaggaa   180
aaaggttatt tcaaagaagc tggagtggat gttgatttga aattgccacc agaagaaagt   240
tcttctgact tggttatcaa cggaaaggca ccatttgcag tgtatttcca agactacatg   300
gctaagaaat tggaaaaagg agcaggaatc actgccgttg cagctattgt tgaacacaat   360
acatcaggaa tcatctctcg taaatctgat aatgtaagca gtccaaaaga cttggttggt   420
aagaaatatg ggacatggaa tgacccaact gaacttgcta tgttgaaaac cttggtagaa   480
tctcaaggtg gagactttga gaaggttgaa aaagtaccaa ataacgactc aaactcaatc   540
acaccgattg ccaatggcgt ctttgatact gcttggattt actacggttg ggatggtatc   600
cttgctaaat ctcaaggtgt agatgctaac ttcatgtact tgaaagacta tgtcaaggag   660
tttgactact attcaccagt tatcatcgca aacaacgact atctgaaaga taacaaagaa   720
gaagctcgca aagtcatcca agccatcaaa aaaggctacc aatatgccat ggaacatcca   780
gaagaagctg cagatattct catcaagaat gcacctgaac tcaaggaaaa acgtgacttt   840
gtcatcgaat ctcaaaaata cttgtcaaaa gaatacgcaa gcgacaagga aaaatggggt   900
caatttgacg cagctcgctg gaatgctttc tacaaatggg ataaagaaaa tggtatcctt   960
aaagaagact tgacagacaa aggcttcacc aacgaatttg tgaaa                   1005

<210>   4614
<211>   335
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, substrate-binding protein, putative
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15904044 (0.E+01)

<400>   4614
Met Lys Lys Thr Trp Lys Val Phe Leu Thr Leu Val Thr Ala Leu Val 
1               5                   10                  15      

Ala Val Val Leu Val Ala Cys Gly Gln Gly Thr Ala Ser Lys Asp Asn 
            20                  25                  30          

Lys Glu Ala Glu Leu Lys Lys Val Asp Phe Ile Leu Asp Trp Thr Pro 
        35                  40                  45              

Asn Thr Asn His Thr Gly Leu Tyr Val Ala Lys Glu Lys Gly Tyr Phe 
    50                  55                  60                  

Lys Glu Ala Gly Val Asp Val Asp Leu Lys Leu Pro Pro Glu Glu Ser 
65                  70                  75                  80  

Ser Ser Asp Leu Val Ile Asn Gly Lys Ala Pro Phe Ala Val Tyr Phe 
                85                  90                  95      

Gln Asp Tyr Met Ala Lys Lys Leu Glu Lys Gly Ala Gly Ile Thr Ala 
            100                 105                 110         

Val Ala Ala Ile Val Glu His Asn Thr Ser Gly Ile Ile Ser Arg Lys 
        115                 120                 125             

Ser Asp Asn Val Ser Ser Pro Lys Asp Leu Val Gly Lys Lys Tyr Gly 
    130                 135                 140                 

Thr Trp Asn Asp Pro Thr Glu Leu Ala Met Leu Lys Thr Leu Val Glu 
145                 150                 155                 160 

Ser Gln Gly Gly Asp Phe Glu Lys Val Glu Lys Val Pro Asn Asn Asp 
                165                 170                 175     

Ser Asn Ser Ile Thr Pro Ile Ala Asn Gly Val Phe Asp Thr Ala Trp 
            180                 185                 190         

Ile Tyr Tyr Gly Trp Asp Gly Ile Leu Ala Lys Ser Gln Gly Val Asp 

        195                 200                 205             

Ala Asn Phe Met Tyr Leu Lys Asp Tyr Val Lys Glu Phe Asp Tyr Tyr 
    210                 215                 220                 

Ser Pro Val Ile Ile Ala Asn Asn Asp Tyr Leu Lys Asp Asn Lys Glu 
225                 230                 235                 240 

Glu Ala Arg Lys Val Ile Gln Ala Ile Lys Lys Gly Tyr Gln Tyr Ala 
                245                 250                 255     

Met Glu His Pro Glu Glu Ala Ala Asp Ile Leu Ile Lys Asn Ala Pro 
            260                 265                 270         

Glu Leu Lys Glu Lys Arg Asp Phe Val Ile Glu Ser Gln Lys Tyr Leu 
        275                 280                 285             

Ser Lys Glu Tyr Ala Ser Asp Lys Glu Lys Trp Gly Gln Phe Asp Ala 
    290                 295                 300                 

Ala Arg Trp Asn Ala Phe Tyr Lys Trp Asp Lys Glu Asn Gly Ile Leu 
305                 310                 315                 320 

Lys Glu Asp Leu Thr Asp Lys Gly Phe Thr Asn Glu Phe Val Lys 
                325                 330                 335 

<210>   4615
<211>   747
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4615
ttgagaagta tactgagacg acacattagt ctattgggct ttctcggagt attgtcaatc   60
tggcagttag caggttttct taaacttctc cccaagttta tcctgccgac acctcttgaa   120
attctccagc cctttgttcg tgacagagaa tttctctggc accatagctg ggcgaccttg   180
agagtggctt tactggggct gattttggga gttttgattg cctgtcttat ggctgtgctc   240
atggatagtt tgacttggct caatgacctg atttacccta tgatggtggt cattcagacc   300
attccgacca ttgccatagc tcctatcctg gtcttgtggc taggttatgg gattttgccc   360
aagattgtct tgattatctt aacgacaacc tttcccatca tcgttagtat tttggacggt   420
tttaggcatt gcgacaagga tatgctgacc ttgtttagtc tgatgcgggc caagccttgg   480
caaatcctgt ggcattttaa aatcccagtt agcctgcctt acttttatgc aggtctgagg   540
gtcagtgtct cctacgcctt tatcacaact gtggtatctg agtggttggg aggttttgaa   600
ggtcttggtg tttatatgat tcagtctaaa aaactgtttc agtatgatac catgtttgcc   660
attattattc tggtgtcgat tatcagtctt ttgggtatga agctggtcga tatcagtgaa   720
aaatatgtga ttaaatggaa acgttcg                                       747

<210>   4616
<211>   249
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904045 (e-140)

<400>   4616
Met Arg Ser Ile Leu Arg Arg His Ile Ser Leu Leu Gly Phe Leu Gly 
1               5                   10                  15      

Val Leu Ser Ile Trp Gln Leu Ala Gly Phe Leu Lys Leu Leu Pro Lys 
            20                  25                  30          

Phe Ile Leu Pro Thr Pro Leu Glu Ile Leu Gln Pro Phe Val Arg Asp 
        35                  40                  45              

Arg Glu Phe Leu Trp His His Ser Trp Ala Thr Leu Arg Val Ala Leu 
    50                  55                  60                  

Leu Gly Leu Ile Leu Gly Val Leu Ile Ala Cys Leu Met Ala Val Leu 
65                  70                  75                  80  

Met Asp Ser Leu Thr Trp Leu Asn Asp Leu Ile Tyr Pro Met Met Val 
                85                  90                  95      

Val Ile Gln Thr Ile Pro Thr Ile Ala Ile Ala Pro Ile Leu Val Leu 
            100                 105                 110         

Trp Leu Gly Tyr Gly Ile Leu Pro Lys Ile Val Leu Ile Ile Leu Thr 
        115                 120                 125             

Thr Thr Phe Pro Ile Ile Val Ser Ile Leu Asp Gly Phe Arg His Cys 
    130                 135                 140                 

Asp Lys Asp Met Leu Thr Leu Phe Ser Leu Met Arg Ala Lys Pro Trp 
145                 150                 155                 160 

Gln Ile Leu Trp His Phe Lys Ile Pro Val Ser Leu Pro Tyr Phe Tyr 
                165                 170                 175     

Ala Gly Leu Arg Val Ser Val Ser Tyr Ala Phe Ile Thr Thr Val Val 
            180                 185                 190         

Ser Glu Trp Leu Gly Gly Phe Glu Gly Leu Gly Val Tyr Met Ile Gln 
        195                 200                 205             

Ser Lys Lys Leu Phe Gln Tyr Asp Thr Met Phe Ala Ile Ile Ile Leu 
    210                 215                 220                 

Val Ser Ile Ile Ser Leu Leu Gly Met Lys Leu Val Asp Ile Ser Glu 
225                 230                 235                 240 

Lys Tyr Val Ile Lys Trp Lys Arg Ser 
                245                 

<210>   4617
<211>   270
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4617
ttgcaagttt tacccctagt acaggggatt gatcggatag ctgttattga tcaggtcatt   60
gcttatctgc aaactcaaga agtgacgatg gtagtgacac catttgaaac ggtcttggaa   120
ggggagtttg atgagcttat gcgcattcta aaagaagcgc tggaagtggc agggcaggag   180
gcagacaatg tctttgccaa tgtcaaaata aatgtaggag agattttaag tattgatgag   240
aaacttgaga agtatactga gacgacacat                                    270

<210>   4618
<211>   90
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15904046 (4.E-48)

<400>   4618
Met Gln Val Leu Pro Leu Val Gln Gly Ile Asp Arg Ile Ala Val Ile 
1               5                   10                  15      

Asp Gln Val Ile Ala Tyr Leu Gln Thr Gln Glu Val Thr Met Val Val 
            20                  25                  30          

Thr Pro Phe Glu Thr Val Leu Glu Gly Glu Phe Asp Glu Leu Met Arg 
        35                  40                  45              

Ile Leu Lys Glu Ala Leu Glu Val Ala Gly Gln Glu Ala Asp Asn Val 
    50                  55                  60                  

Phe Ala Asn Val Lys Ile Asn Val Gly Glu Ile Leu Ser Ile Asp Glu 
65                  70                  75                  80  

Lys Leu Glu Lys Tyr Thr Glu Thr Thr His 
                85                  90  

<210>   4619
<211>   108
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4619
atgatagcgc aaaataagaa aaatgtcaag gaaactgctt acagaaaaga gcaggaaatt   60
tctcctactc caattttcta tactcgttct ccatcactgt ttactctg                108

<210>   4620
<211>   36
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4620
Met Ile Ala Gln Asn Lys Lys Asn Val Lys Glu Thr Ala Tyr Arg Lys 
1               5                   10                  15      

Glu Gln Glu Ile Ser Pro Thr Pro Ile Phe Tyr Thr Arg Ser Pro Ser 
            20                  25                  30          

Leu Phe Thr Leu 
        35      

<210>   4621
<211>   1344
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4621
atgaaaattt taccgtttat agcaagagga acaagttatt acttgaagat gtcagttaaa   60
aagcttgttc cttttttagt agtaggattg atgctagcag ctggtgatag tgtctatgcc   120
tattccagag gaaatggatc gattgcgcgt ggggatgatt atcctgctta ttataaaaat   180
gggagccagg agattgatca gtggcgcatg tattctcgtc agtgtacttc ttttgtagcc   240
tttcgtttga gtaatgtcaa tggttttgaa attccggcag cttatggaaa tgcgaatgaa   300
tggggacatc gtgctcgtcg ggaaggttat cgtgtagata atacaccgac gattggttcc   360
attacttggt ctactgcagg aacttatggt catgttgcct gggtgtcaaa tgtaatggga   420
gatcagattg agattgagga atataactat ggttatacag aatcctataa taaacgagtt   480
ataaaagcaa acacgatgac aggatttatt cattttaaag atttggatgg tggcagtgtt   540
gggaatagtc aatcctcaac ttcaacaggc ggaactcatt attttaagac caagtctgct   600
attaaaactg aacctctagc tagcggaact gtgattgatt actattatcc tggggagaag   660
gttcattatg atcagatact tgaaaaagac ggctataagt ggttgagtta tactgcctat   720
aatggaagct atcgttatgt tcaattggag gctgtgaata aaaatcctct aggtaattct   780
gttctttctt caacaggtgg aactcattat tttaagacca agtctgctat caaaactgaa   840
cccctagtta gtgcaactgt gattgattac tattatcctg gagagaaggt tcattatgat   900
caaattctcg aaaaagacgg ctacaagtgg ttgagttata cggcttataa cggaagtcgt   960
cgctatatac agctagaggg agtgacttct tcacaaaatt atcagaatca atcaggaaac   1020
atctctagct atggatccca tagtagttca actgtcggtt ggaagaaaat aaatggtagt   1080
tggtatcatt tcaaatcaaa tggttctaaa tcaacaggat ggctgaaaga cggttctagc   1140
tggtattatt tgaaattatc tggtgaaatg cagacaggat ggttaaagga aaatggtttg   1200
tggtattatc tgggtagttc aggggcaatg aaaacaggct ggtaccaggt ctctggtaag   1260
tggtattatt cttactcttc aggcgcctta gctgttaata cgacggtgga tggctacaga   1320
gtaaacagtg atggagaacg agta                                          1344

<210>   4622
<211>   448
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline binding protein D (cbpD)
<223>   Cellular location: membrane
<223>   Feature of note: WYY motif, RGD motif
<223>   Similar to strain R6 sequence 15904047 (0.E+01)

<400>   4622
Met Lys Ile Leu Pro Phe Ile Ala Arg Gly Thr Ser Tyr Tyr Leu Lys 
1               5                   10                  15      

Met Ser Val Lys Lys Leu Val Pro Phe Leu Val Val Gly Leu Met Leu 
            20                  25                  30          

Ala Ala Gly Asp Ser Val Tyr Ala Tyr Ser Arg Gly Asn Gly Ser Ile 
        35                  40                  45              

Ala Arg Gly Asp Asp Tyr Pro Ala Tyr Tyr Lys Asn Gly Ser Gln Glu 
    50                  55                  60                  

Ile Asp Gln Trp Arg Met Tyr Ser Arg Gln Cys Thr Ser Phe Val Ala 
65                  70                  75                  80  

Phe Arg Leu Ser Asn Val Asn Gly Phe Glu Ile Pro Ala Ala Tyr Gly 
                85                  90                  95      

Asn Ala Asn Glu Trp Gly His Arg Ala Arg Arg Glu Gly Tyr Arg Val 
            100                 105                 110         

Asp Asn Thr Pro Thr Ile Gly Ser Ile Thr Trp Ser Thr Ala Gly Thr 
        115                 120                 125             

Tyr Gly His Val Ala Trp Val Ser Asn Val Met Gly Asp Gln Ile Glu 
    130                 135                 140                 

Ile Glu Glu Tyr Asn Tyr Gly Tyr Thr Glu Ser Tyr Asn Lys Arg Val 
145                 150                 155                 160 

Ile Lys Ala Asn Thr Met Thr Gly Phe Ile His Phe Lys Asp Leu Asp 
                165                 170                 175     

Gly Gly Ser Val Gly Asn Ser Gln Ser Ser Thr Ser Thr Gly Gly Thr 
            180                 185                 190         

His Tyr Phe Lys Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Ala Ser 
        195                 200                 205             

Gly Thr Val Ile Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp 
    210                 215                 220                 

Gln Ile Leu Glu Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr 
225                 230                 235                 240 

Asn Gly Ser Tyr Arg Tyr Val Gln Leu Glu Ala Val Asn Lys Asn Pro 
                245                 250                 255     

Leu Gly Asn Ser Val Leu Ser Ser Thr Gly Gly Thr His Tyr Phe Lys 
            260                 265                 270         

Thr Lys Ser Ala Ile Lys Thr Glu Pro Leu Val Ser Ala Thr Val Ile 
        275                 280                 285             


Asp Tyr Tyr Tyr Pro Gly Glu Lys Val His Tyr Asp Gln Ile Leu Glu 
    290                 295                 300                 

Lys Asp Gly Tyr Lys Trp Leu Ser Tyr Thr Ala Tyr Asn Gly Ser Arg 
305                 310                 315                 320 

Arg Tyr Ile Gln Leu Glu Gly Val Thr Ser Ser Gln Asn Tyr Gln Asn 
                325                 330                 335     

Gln Ser Gly Asn Ile Ser Ser Tyr Gly Ser His Ser Ser Ser Thr Val 
            340                 345                 350         

Gly Trp Lys Lys Ile Asn Gly Ser Trp Tyr His Phe Lys Ser Asn Gly 
        355                 360                 365             

Ser Lys Ser Thr Gly Trp Leu Lys Asp Gly Ser Ser Trp Tyr Tyr Leu 
    370                 375                 380                 

Lys Leu Ser Gly Glu Met Gln Thr Gly Trp Leu Lys Glu Asn Gly Leu 
385                 390                 395                 400 

Trp Tyr Tyr Leu Gly Ser Ser Gly Ala Met Lys Thr Gly Trp Tyr Gln 
                405                 410                 415     

Val Ser Gly Lys Trp Tyr Tyr Ser Tyr Ser Ser Gly Ala Leu Ala Val 
            420                 425                 430         

Asn Thr Thr Val Asp Gly Tyr Arg Val Asn Ser Asp Gly Glu Arg Val 
        435                 440                 445             


<210>   4623
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4623
atgtcagatg catttacaga tgtagccaag atgaaaaaaa tcaaagaaga aatcaaggca   60
catgagggac aagtcgtaga aatgactttg gagaatggtc gtaagcgcca aaaaaataga   120
ttgggtaagc taattgaagt ttatccatct ctatttattg tggagtttgg ggatgtggaa   180
ggagataaac aagttaatgt ttacgttgaa tcctttactt actcagatat tcttacagaa   240
aagaatttga ttcattatct tgac                                          264

<210>   4624
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904048 (2.E-46)

<400>   4624
Met Ser Asp Ala Phe Thr Asp Val Ala Lys Met Lys Lys Ile Lys Glu 
1               5                   10                  15      

Glu Ile Lys Ala His Glu Gly Gln Val Val Glu Met Thr Leu Glu Asn 
            20                  25                  30          

Gly Arg Lys Arg Gln Lys Asn Arg Leu Gly Lys Leu Ile Glu Val Tyr 
        35                  40                  45              

Pro Ser Leu Phe Ile Val Glu Phe Gly Asp Val Glu Gly Asp Lys Gln 
    50                  55                  60                  

Val Asn Val Tyr Val Glu Ser Phe Thr Tyr Ser Asp Ile Leu Thr Glu 
65                  70                  75                  80  

Lys Asn Leu Ile His Tyr Leu Asp 
                85              

<210>   4625
<211>   1350
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4625
atggcagaag tagaagagtt acgagtacaa cctcaagata tcttagctga gcaatccgtt   60
ttaggggcta tctttattga tgagagtaaa cttgtttttg tgcgagaata cattgagtct   120
cgggactttt ttaagtatgc ccatcgtttg attttccaag ccatggtcga tttatccgat   180
cgtggtgatg ccatagatgc aacaacggtt cgtactatcc ttgataatca aggtgattta   240
cagaatattg gtggcttgtc ttacttggtt gagattgtta attctgtgcc aacttctgct   300
aatgcggagt attatgctaa gattgttgca gaaaaagcaa tgctacgtcg tttaattgcc   360
aagttgacag agtctgtcaa ccaagcttac gaagcgtcac aaccagctga tgaaattatt   420
gctcaggcag aaaaagggtt gattgatgtc agtgaaaatg caaatcgaag cgggtttaag   480
aacattcgag atgtgttgaa tctcaacttt ggaaatctgg aagctcgctc gcaacaaacg   540
accgatatta caggtattgc gacaggttat cgtgatttgg atcatatgac aacaggactt   600
catgaggagg agttgattat cttagcagct cgtccagcag ttggtaagac agcatttgcc   660
ttgaatatcg ctcagaacat tgggactaag ttggacaaaa cggttgctat tttttcactc   720
gaaatgggtg cggaaagctt ggtagatcgt atgttagctg cagaaggctt agtggagtca   780
cattctatcc gtacagggca attgacagat gaggagtggc aaaaatatac tattgctcag   840
ggtaatctag ctaacgccag tatctatatc gatgatacgc caggtattcg gattacagag   900
attcgttctc gttctcgtaa attggctcaa gaaactggaa atcttggttt gattttgata   960
gactatttgc aacttatcac gggaactggt cgagaaaatc gtcaacaaga agtttctgaa   1020
atttctcgtc agttgaaaat actagccaag gaattgaagg ttccagtaat cgctctgagt   1080
cagctttctc gtggtgtaga acaacgtcag gacaagagac cggtcttgtc tgatattcgt   1140
gaatctgggt ctattgagca ggacgctgat atcgtagctt ttctctatcg cgatgactac   1200
tatgaacgtg gtggtgaaga agaggagggt atcccaaata ataaggtgga agttattatc   1260
gagaaaaacc gtagtggagc tcgtggaaca gtggaattga ttttccaaaa agaatacaat   1320
aaattttcaa gtatctcaaa gagggaggca                                    1350

<210>   4626
<211>   450
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   replicative DNA helicase (dnaC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904049 (0.E+01)

<400>   4626
Met Ala Glu Val Glu Glu Leu Arg Val Gln Pro Gln Asp Ile Leu Ala 
1               5                   10                  15      

Glu Gln Ser Val Leu Gly Ala Ile Phe Ile Asp Glu Ser Lys Leu Val 
            20                  25                  30          


Phe Val Arg Glu Tyr Ile Glu Ser Arg Asp Phe Phe Lys Tyr Ala His 
        35                  40                  45              

Arg Leu Ile Phe Gln Ala Met Val Asp Leu Ser Asp Arg Gly Asp Ala 
    50                  55                  60                  

Ile Asp Ala Thr Thr Val Arg Thr Ile Leu Asp Asn Gln Gly Asp Leu 
65                  70                  75                  80  

Gln Asn Ile Gly Gly Leu Ser Tyr Leu Val Glu Ile Val Asn Ser Val 
                85                  90                  95      

Pro Thr Ser Ala Asn Ala Glu Tyr Tyr Ala Lys Ile Val Ala Glu Lys 
            100                 105                 110         

Ala Met Leu Arg Arg Leu Ile Ala Lys Leu Thr Glu Ser Val Asn Gln 
        115                 120                 125             

Ala Tyr Glu Ala Ser Gln Pro Ala Asp Glu Ile Ile Ala Gln Ala Glu 
    130                 135                 140                 

Lys Gly Leu Ile Asp Val Ser Glu Asn Ala Asn Arg Ser Gly Phe Lys 
145                 150                 155                 160 

Asn Ile Arg Asp Val Leu Asn Leu Asn Phe Gly Asn Leu Glu Ala Arg 
                165                 170                 175     

Ser Gln Gln Thr Thr Asp Ile Thr Gly Ile Ala Thr Gly Tyr Arg Asp 
            180                 185                 190         

Leu Asp His Met Thr Thr Gly Leu His Glu Glu Glu Leu Ile Ile Leu 
        195                 200                 205             

Ala Ala Arg Pro Ala Val Gly Lys Thr Ala Phe Ala Leu Asn Ile Ala 
    210                 215                 220                 

Gln Asn Ile Gly Thr Lys Leu Asp Lys Thr Val Ala Ile Phe Ser Leu 
225                 230                 235                 240 

Glu Met Gly Ala Glu Ser Leu Val Asp Arg Met Leu Ala Ala Glu Gly 
                245                 250                 255     

Leu Val Glu Ser His Ser Ile Arg Thr Gly Gln Leu Thr Asp Glu Glu 
            260                 265                 270         

Trp Gln Lys Tyr Thr Ile Ala Gln Gly Asn Leu Ala Asn Ala Ser Ile 
        275                 280                 285             

Tyr Ile Asp Asp Thr Pro Gly Ile Arg Ile Thr Glu Ile Arg Ser Arg 
    290                 295                 300                 

Ser Arg Lys Leu Ala Gln Glu Thr Gly Asn Leu Gly Leu Ile Leu Ile 
305                 310                 315                 320 

Asp Tyr Leu Gln Leu Ile Thr Gly Thr Gly Arg Glu Asn Arg Gln Gln 
                325                 330                 335     

Glu Val Ser Glu Ile Ser Arg Gln Leu Lys Ile Leu Ala Lys Glu Leu 
            340                 345                 350         

Lys Val Pro Val Ile Ala Leu Ser Gln Leu Ser Arg Gly Val Glu Gln 
        355                 360                 365             

Arg Gln Asp Lys Arg Pro Val Leu Ser Asp Ile Arg Glu Ser Gly Ser 
    370                 375                 380                 

Ile Glu Gln Asp Ala Asp Ile Val Ala Phe Leu Tyr Arg Asp Asp Tyr 
385                 390                 395                 400 

Tyr Glu Arg Gly Gly Glu Glu Glu Glu Gly Ile Pro Asn Asn Lys Val 
                405                 410                 415     

Glu Val Ile Ile Glu Lys Asn Arg Ser Gly Ala Arg Gly Thr Val Glu 
            420                 425                 430         

Leu Ile Phe Gln Lys Glu Tyr Asn Lys Phe Ser Ser Ile Ser Lys Arg 
        435                 440                 445             

Glu Ala 
    450 

<210>   4627
<211>   450
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4627
atgaaagtaa tctttttagc agatgttaaa ggaaaaggta aaaaaggcga aattaaggaa   60
gtaccaacag ggtatgcgca aaactttctt atcaaaaaga atctagccaa agaagcgact   120
gctcaagctg taggtgaact tcgtggtaaa caaaaatcgg aagaaaaagc tcacgctgag   180
atgattgcag aaggaaaagc aattaaagca caacttgaag cagaagaaac tgttgtagaa   240
tttgttgaaa aagttggtcc agatggtcgt acctttggtt ctattaccaa taagaagatt   300
gcagaagaat tgcaaaagca atttggaatt aagattgata aacgtcatat tcaagtacaa   360
gctccgattc gagcggttgg tttgattgat gtgccagtga aaatctatca agatatcaca   420
agtgtaatca atcttcgtgt gaaagaagga                                    450

<210>   4628
<211>   150
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L9 (rplI)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904050 (3.E-80)

<400>   4628
Met Lys Val Ile Phe Leu Ala Asp Val Lys Gly Lys Gly Lys Lys Gly 
1               5                   10                  15      

Glu Ile Lys Glu Val Pro Thr Gly Tyr Ala Gln Asn Phe Leu Ile Lys 
            20                  25                  30          

Lys Asn Leu Ala Lys Glu Ala Thr Ala Gln Ala Val Gly Glu Leu Arg 
        35                  40                  45              

Gly Lys Gln Lys Ser Glu Glu Lys Ala His Ala Glu Met Ile Ala Glu 
    50                  55                  60                  

Gly Lys Ala Ile Lys Ala Gln Leu Glu Ala Glu Glu Thr Val Val Glu 
65                  70                  75                  80  

Phe Val Glu Lys Val Gly Pro Asp Gly Arg Thr Phe Gly Ser Ile Thr 
                85                  90                  95      

Asn Lys Lys Ile Ala Glu Glu Leu Gln Lys Gln Phe Gly Ile Lys Ile 
            100                 105                 110         

Asp Lys Arg His Ile Gln Val Gln Ala Pro Ile Arg Ala Val Gly Leu 
        115                 120                 125             

Ile Asp Val Pro Val Lys Ile Tyr Gln Asp Ile Thr Ser Val Ile Asn 
    130                 135                 140                 

Leu Arg Val Lys Glu Gly 
145                 150 

<210>   4629
<211>   1971
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4629
atgaaaaaat tttatgtaag tccaattttt cctattctag taggattgat tgcgtttgga   60
gtcttatcca ctttcattat ttttgttaat aataatctgt tgacggtttt aattttgttt   120
ctttttgtag gaggctatgt ttttttattt aagaaactga gagtgcatta tacaaggagt   180
gatgtagaac agatacagta tgtaaaccac caagcggaag aaagtttgac agctctattg   240
gaacagatgc ctgtaggtgt tatgaaattg aatttatctt ctggagaggt tgagtggttt   300
aatccctatg ctgaattgat tttgaccaag gaagatggtg attttgattt agaagctgtt   360
caaacgatta tcaaggcttc agtaggaaat ccgtctactt atgccaagct tggtgagaag   420
cgttatgctg ttcatatgga tgcttcttcc ggtgttttgt attttgtaga tgtatccagg   480
gaacaagcca taacagatga attggtaaca agtagaccag tgattgggat tgtctctgtg   540
gataattatg atgatttgga ggatgaaact tctgagtcag atattagtca aatcaatagt   600
tttgtagcta attttatatc agagttttca gaaaaacaca tgatgttttc tcgtcgggta   660
agtatggatc gattttatct atttactgac tacacggtgc ttgagggctt gatgaatgat   720
aaattttctg ttattgatgc tttcagagaa gagtcgaaac agagacagtt gcccttgacc   780
ttaagtatgg gattttctta tggcgatgga aatcatgatg agatagggaa agttgctttg   840
ctcaatttga acttggctga agtacgtggt ggcgaccagg tggttgttaa ggaaaacgac   900
gaaacgaaaa atccagttta ttttggtggt gggtctgctg cttcaatcaa gcgtacacgg   960
actcgtacgc gcgctatgat gacagctatt tcagataaga ttcggagtgt agatcaggtt   1020
tttgtagtcg gtcacaaaaa tttagacatg gatgctttgg gctctgctgt aggtatgcag   1080
ttgttcgcca gcaatgtgat tgaaaatagc tatgctcttt atgatgaaga acaaatgtct   1140
ccagatattg aacgagctgt ttcattcata gaaaaagaag gagttacgaa gttgttgtct   1200
gttaaggatg caatggggat ggtgaccaat cgttctttgt tgattcttgt agaccattca   1260
aagacagcct taacattatc aaaagaattt tatgatttat ttacccaaac cattgttatt   1320
gaccaccata gaagggatca ggattttcca gataatgcgg ttattactta tatcgaaagt   1380
ggtgcaagta gtgccagtga gttggtaacg gaattgattc agttccagaa ttctaagaaa   1440
aatcgtttga gtcgtatgca agcaagtgtc ttgatggctg gtatgatgtt ggatactaaa   1500
aatttcacct cgcgagtaac tagtcggaca tttgatgttg ctagctatct cagaacgcgc   1560
ggaagtgata gtattgctat ccaggaaatc gctgcgacag attttgaaga atatcgtgag   1620
gtcaatgaac ttattttaca ggggcgtaaa ttaggttcag atgtactaat agcagaggct   1680
aaggacatga aatgctatga tacagttgtt attagtaagg cagcagatgc catgttagcc   1740
atgtcaggta ttgaagcgag ttttgttctt gcgaagaata cacaaggatt tatctctatc   1800
tcagctcgaa gtcgtagtaa actgaatgta caacggatta tggaagagtt aggcggtgga   1860
ggccacttta atttggcagc agctcaaatt aaagatgtaa ccttgtcaga agcaggtgaa   1920
aaactgacag aaattgtatt aaatgaaatg aaggaaaagg agaaagaaga a            1971

<210>   4630
<211>   657
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DHH subfamily 1 protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904051 (0.E+01)

<400>   4630
Met Lys Lys Phe Tyr Val Ser Pro Ile Phe Pro Ile Leu Val Gly Leu 
1               5                   10                  15      

Ile Ala Phe Gly Val Leu Ser Thr Phe Ile Ile Phe Val Asn Asn Asn 
            20                  25                  30          

Leu Leu Thr Val Leu Ile Leu Phe Leu Phe Val Gly Gly Tyr Val Phe 
        35                  40                  45              

Leu Phe Lys Lys Leu Arg Val His Tyr Thr Arg Ser Asp Val Glu Gln 
    50                  55                  60                  

Ile Gln Tyr Val Asn His Gln Ala Glu Glu Ser Leu Thr Ala Leu Leu 
65                  70                  75                  80  

Glu Gln Met Pro Val Gly Val Met Lys Leu Asn Leu Ser Ser Gly Glu 
                85                  90                  95      

Val Glu Trp Phe Asn Pro Tyr Ala Glu Leu Ile Leu Thr Lys Glu Asp 
            100                 105                 110         

Gly Asp Phe Asp Leu Glu Ala Val Gln Thr Ile Ile Lys Ala Ser Val 
        115                 120                 125             

Gly Asn Pro Ser Thr Tyr Ala Lys Leu Gly Glu Lys Arg Tyr Ala Val 
    130                 135                 140                 

His Met Asp Ala Ser Ser Gly Val Leu Tyr Phe Val Asp Val Ser Arg 
145                 150                 155                 160 

Glu Gln Ala Ile Thr Asp Glu Leu Val Thr Ser Arg Pro Val Ile Gly 
                165                 170                 175     

Ile Val Ser Val Asp Asn Tyr Asp Asp Leu Glu Asp Glu Thr Ser Glu 
            180                 185                 190         

Ser Asp Ile Ser Gln Ile Asn Ser Phe Val Ala Asn Phe Ile Ser Glu 
        195                 200                 205             

Phe Ser Glu Lys His Met Met Phe Ser Arg Arg Val Ser Met Asp Arg 
    210                 215                 220                 

Phe Tyr Leu Phe Thr Asp Tyr Thr Val Leu Glu Gly Leu Met Asn Asp 
225                 230                 235                 240 

Lys Phe Ser Val Ile Asp Ala Phe Arg Glu Glu Ser Lys Gln Arg Gln 
                245                 250                 255     

Leu Pro Leu Thr Leu Ser Met Gly Phe Ser Tyr Gly Asp Gly Asn His 
            260                 265                 270         

Asp Glu Ile Gly Lys Val Ala Leu Leu Asn Leu Asn Leu Ala Glu Val 
        275                 280                 285             

Arg Gly Gly Asp Gln Val Val Val Lys Glu Asn Asp Glu Thr Lys Asn 
    290                 295                 300                 

Pro Val Tyr Phe Gly Gly Gly Ser Ala Ala Ser Ile Lys Arg Thr Arg 
305                 310                 315                 320 

Thr Arg Thr Arg Ala Met Met Thr Ala Ile Ser Asp Lys Ile Arg Ser 
                325                 330                 335     

Val Asp Gln Val Phe Val Val Gly His Lys Asn Leu Asp Met Asp Ala 
            340                 345                 350         

Leu Gly Ser Ala Val Gly Met Gln Leu Phe Ala Ser Asn Val Ile Glu 
        355                 360                 365             

Asn Ser Tyr Ala Leu Tyr Asp Glu Glu Gln Met Ser Pro Asp Ile Glu 
    370                 375                 380                 

Arg Ala Val Ser Phe Ile Glu Lys Glu Gly Val Thr Lys Leu Leu Ser 
385                 390                 395                 400 

Val Lys Asp Ala Met Gly Met Val Thr Asn Arg Ser Leu Leu Ile Leu 
                405                 410                 415     

Val Asp His Ser Lys Thr Ala Leu Thr Leu Ser Lys Glu Phe Tyr Asp 
            420                 425                 430         

Leu Phe Thr Gln Thr Ile Val Ile Asp His His Arg Arg Asp Gln Asp 
        435                 440                 445             

Phe Pro Asp Asn Ala Val Ile Thr Tyr Ile Glu Ser Gly Ala Ser Ser 
    450                 455                 460                 

Ala Ser Glu Leu Val Thr Glu Leu Ile Gln Phe Gln Asn Ser Lys Lys 
465                 470                 475                 480 

Asn Arg Leu Ser Arg Met Gln Ala Ser Val Leu Met Ala Gly Met Met 
                485                 490                 495     

Leu Asp Thr Lys Asn Phe Thr Ser Arg Val Thr Ser Arg Thr Phe Asp 
            500                 505                 510         

Val Ala Ser Tyr Leu Arg Thr Arg Gly Ser Asp Ser Ile Ala Ile Gln 
        515                 520                 525             

Glu Ile Ala Ala Thr Asp Phe Glu Glu Tyr Arg Glu Val Asn Glu Leu 
    530                 535                 540                 

Ile Leu Gln Gly Arg Lys Leu Gly Ser Asp Val Leu Ile Ala Glu Ala 
545                 550                 555                 560 

Lys Asp Met Lys Cys Tyr Asp Thr Val Val Ile Ser Lys Ala Ala Asp 
                565                 570                 575     

Ala Met Leu Ala Met Ser Gly Ile Glu Ala Ser Phe Val Leu Ala Lys 
            580                 585                 590         

Asn Thr Gln Gly Phe Ile Ser Ile Ser Ala Arg Ser Arg Ser Lys Leu 
        595                 600                 605             

Asn Val Gln Arg Ile Met Glu Glu Leu Gly Gly Gly Gly His Phe Asn 
    610                 615                 620                 

Leu Ala Ala Ala Gln Ile Lys Asp Val Thr Leu Ser Glu Ala Gly Glu 
625                 630                 635                 640 

Lys Leu Thr Glu Ile Val Leu Asn Glu Met Lys Glu Lys Glu Lys Glu 
                645                 650                 655     

Glu 
    

<210>   4631
<211>   546
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4631
atgattaaat atagtatccg tggtgaaaac ctagaagtaa cagaagcaat tcgtgattat   60
gtagtttcta aactcgaaaa gatcgaaaag tacttccaac cagaacaaga gttggatgcc   120
cgaattaact taaaagttta tcgtgaaaaa acggctaaag tggaagtaac gattccgctt   180
ggatctatta ctctccgcgc agaagatgta tctcaagata tgtatggttc aattgacctt   240
gtaactgata aaattgaacg tcagattcgt aaaaataaaa caaaaatcga gcgtaaaaat   300
aaaaataagg tagcaactgg tcaattattt acagatgctt tggtggaaga ttcaaatatt   360
gtccagtcta aagttgttcg ttcaaaacaa attgatttaa aaccaatgga tttggaagaa   420
gcaattctac aaatggattt attggggcat gatttcttta tctatgtgga tgttgaagat   480
cagacaacca atgtgattta tcgtcgtgag gatggcgaaa ttggtttgtt agaggttaaa   540
gaatct                                                              546

<210>   4632
<211>   182
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal subunit interface protein (yfiA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904052 (1.E-98)

<400>   4632
Met Ile Lys Tyr Ser Ile Arg Gly Glu Asn Leu Glu Val Thr Glu Ala 
1               5                   10                  15      

Ile Arg Asp Tyr Val Val Ser Lys Leu Glu Lys Ile Glu Lys Tyr Phe 
            20                  25                  30          

Gln Pro Glu Gln Glu Leu Asp Ala Arg Ile Asn Leu Lys Val Tyr Arg 
        35                  40                  45              

Glu Lys Thr Ala Lys Val Glu Val Thr Ile Pro Leu Gly Ser Ile Thr 
    50                  55                  60                  

Leu Arg Ala Glu Asp Val Ser Gln Asp Met Tyr Gly Ser Ile Asp Leu 
65                  70                  75                  80  

Val Thr Asp Lys Ile Glu Arg Gln Ile Arg Lys Asn Lys Thr Lys Ile 
                85                  90                  95      

Glu Arg Lys Asn Lys Asn Lys Val Ala Thr Gly Gln Leu Phe Thr Asp 
            100                 105                 110         

Ala Leu Val Glu Asp Ser Asn Ile Val Gln Ser Lys Val Val Arg Ser 
        115                 120                 125             

Lys Gln Ile Asp Leu Lys Pro Met Asp Leu Glu Glu Ala Ile Leu Gln 
    130                 135                 140                 

Met Asp Leu Leu Gly His Asp Phe Phe Ile Tyr Val Asp Val Glu Asp 
145                 150                 155                 160 

Gln Thr Thr Asn Val Ile Tyr Arg Arg Glu Asp Gly Glu Ile Gly Leu 
                165                 170                 175     

Leu Glu Val Lys Glu Ser 
            180         

<210>   4633
<211>   660
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4633
atgaagtgct tgttatgtgg gcagactatg aagactgttt taacttttag tagtctctta   60
cttctgagga atgatgactc ttgtctttgt tcagactgtg attctacttt tgaaagaatt   120
ggggaagaga actgtccaaa ttgtatgaaa acagagttgt caacaaagtg tcaagattgt   180
caactttggt gtaaagaggg agttgaagtc agtcatagag cgatttttac ttacaatcaa   240
gctatgaagg attttttcag tcggtataag tttgatggag acttcctgtt aagaaaagtt   300
ttcgcttcat ttttaagtga ggagttgaaa aagtacaaag agtatcaatt tgttgtaatt   360
cccctaagtc ctgatagata tgctaataga ggatttaatc aggttgaggg cttggtagag   420
gcagcaggct ttgagtatct ggatttatta gagaaaagag aagagagagc cagttcttct   480
aaaaatcgtt cagagcgctt ggggacagaa cttcctttct ttattaaaag tggagtcact   540
attcctaaaa aaatcctact tatagatgat atctatacta caggagcaac tataaatcgt   600
gttaagaaac tgttggaaga agctggtgct aaggatgtaa aaacattttc ccttgtaaga   660

<210>   4634
<211>   220
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence protein ComF, putative
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15904053 (e-126)

<400>   4634
Met Lys Cys Leu Leu Cys Gly Gln Thr Met Lys Thr Val Leu Thr Phe 
1               5                   10                  15      

Ser Ser Leu Leu Leu Leu Arg Asn Asp Asp Ser Cys Leu Cys Ser Asp 
            20                  25                  30          

Cys Asp Ser Thr Phe Glu Arg Ile Gly Glu Glu Asn Cys Pro Asn Cys 
        35                  40                  45              

Met Lys Thr Glu Leu Ser Thr Lys Cys Gln Asp Cys Gln Leu Trp Cys 
    50                  55                  60                  

Lys Glu Gly Val Glu Val Ser His Arg Ala Ile Phe Thr Tyr Asn Gln 
65                  70                  75                  80  

Ala Met Lys Asp Phe Phe Ser Arg Tyr Lys Phe Asp Gly Asp Phe Leu 
                85                  90                  95      

Leu Arg Lys Val Phe Ala Ser Phe Leu Ser Glu Glu Leu Lys Lys Tyr 
            100                 105                 110         

Lys Glu Tyr Gln Phe Val Val Ile Pro Leu Ser Pro Asp Arg Tyr Ala 
        115                 120                 125             

Asn Arg Gly Phe Asn Gln Val Glu Gly Leu Val Glu Ala Ala Gly Phe 
    130                 135                 140                 

Glu Tyr Leu Asp Leu Leu Glu Lys Arg Glu Glu Arg Ala Ser Ser Ser 
145                 150                 155                 160 

Lys Asn Arg Ser Glu Arg Leu Gly Thr Glu Leu Pro Phe Phe Ile Lys 
                165                 170                 175     

Ser Gly Val Thr Ile Pro Lys Lys Ile Leu Leu Ile Asp Asp Ile Tyr 
            180                 185                 190         

Thr Thr Gly Ala Thr Ile Asn Arg Val Lys Lys Leu Leu Glu Glu Ala 
        195                 200                 205             

Gly Ala Lys Asp Val Lys Thr Phe Ser Leu Val Arg 
    210                 215                 220 

<210>   4635
<211>   1296
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4635
atgaaagtaa atttagatta tctcggtcgt ttatttactg agaatgaatt aacagaagaa   60
gaacgtcagt tggcggagaa acttccagca atgagaaagg agaaggggaa acttttctgt   120
caacgctgta atagtactat tctagaagaa tggtatttgc ccatcggtgc ttactattgt   180
cgagagtgct tgctgatgaa gcgagtcaga agtgatcaaa ctttatacta ttttccgcag   240
gaggattttc caaagcaaga tgttctcaaa tggcgcggcc aattaactcc ttttcaagag   300
aaggtgtcag agggattgct tcaagtagta gacaagcaaa agccaacctt agttcatgcg   360
gtaacaggag ctggaaagac agaaatgatt tatcaagtag tggctaaagt gatcaatgcg   420
ggtggtgcag tgtgtttggc tagtcctcgc atagatgttt gtttggagct gtacaagcgc   480
ctgcaacagg atttttcttg cgggatagct ttgctacatg gagaatcgga accttatttt   540
cgaacaccac tagttgttgc aacaacccat cagttattga agttttatca agcttttgat   600
ttgctgatag tggatgaagt agatgctttt ccttatgttg ataatcccat gctttaccac   660
gctgtcaaga atagtgtaaa ggagaatgga ttgagaatct ttttaacagc gacttcgacc   720
aatgagttag ataaaaaggt ccgtttagga gaactaaaaa gactgaattt accgagacgg   780
tttcatggaa atccgttgat tattccaaaa ccaatttggt tatcggattt taatcgctac   840
ttagacaaga atcgtttgtc accaaagtta aagtcctata ttgagaagca gagaaagaca   900
gcttatccgt tactcatttt tgcttcagaa attaagaaag gggagcagtt agcagaaatc   960
ttacaggagc aatttccaaa tgagaaaatt ggctttgtat cttctgtaac agaggatcga   1020
ttagagcaag tacaagcttt tcgagatgga gaactgacaa tacttatcag tacgacaatc   1080
ttggagcgcg gagttacctt cccttgtgtg gatgttttcg tagtagaggc caatcatcgt   1140
ttgtttacca agtctagttt gattcagatt ggtggacgag ttggacgaag catggataga   1200
ccgacaggag atttgctttt cttccatgat gggttaaatg cttcaatcaa gaaggcgatt   1260
aaggaaattc agatgatgaa taaggaggct ggtcta                             1296

<210>   4636
<211>   432
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   helicase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904054 (0.E+01)

<400>   4636
Met Lys Val Asn Leu Asp Tyr Leu Gly Arg Leu Phe Thr Glu Asn Glu 
1               5                   10                  15      

Leu Thr Glu Glu Glu Arg Gln Leu Ala Glu Lys Leu Pro Ala Met Arg 
            20                  25                  30          

Lys Glu Lys Gly Lys Leu Phe Cys Gln Arg Cys Asn Ser Thr Ile Leu 
        35                  40                  45              

Glu Glu Trp Tyr Leu Pro Ile Gly Ala Tyr Tyr Cys Arg Glu Cys Leu 
    50                  55                  60                  

Leu Met Lys Arg Val Arg Ser Asp Gln Thr Leu Tyr Tyr Phe Pro Gln 
65                  70                  75                  80  

Glu Asp Phe Pro Lys Gln Asp Val Leu Lys Trp Arg Gly Gln Leu Thr 
                85                  90                  95      

Pro Phe Gln Glu Lys Val Ser Glu Gly Leu Leu Gln Val Val Asp Lys 
            100                 105                 110         

Gln Lys Pro Thr Leu Val His Ala Val Thr Gly Ala Gly Lys Thr Glu 
        115                 120                 125             


Met Ile Tyr Gln Val Val Ala Lys Val Ile Asn Ala Gly Gly Ala Val 
    130                 135                 140                 

Cys Leu Ala Ser Pro Arg Ile Asp Val Cys Leu Glu Leu Tyr Lys Arg 
145                 150                 155                 160 

Leu Gln Gln Asp Phe Ser Cys Gly Ile Ala Leu Leu His Gly Glu Ser 
                165                 170                 175     

Glu Pro Tyr Phe Arg Thr Pro Leu Val Val Ala Thr Thr His Gln Leu 
            180                 185                 190         

Leu Lys Phe Tyr Gln Ala Phe Asp Leu Leu Ile Val Asp Glu Val Asp 
        195                 200                 205             

Ala Phe Pro Tyr Val Asp Asn Pro Met Leu Tyr His Ala Val Lys Asn 
    210                 215                 220                 

Ser Val Lys Glu Asn Gly Leu Arg Ile Phe Leu Thr Ala Thr Ser Thr 
225                 230                 235                 240 

Asn Glu Leu Asp Lys Lys Val Arg Leu Gly Glu Leu Lys Arg Leu Asn 
                245                 250                 255     

Leu Pro Arg Arg Phe His Gly Asn Pro Leu Ile Ile Pro Lys Pro Ile 
            260                 265                 270         

Trp Leu Ser Asp Phe Asn Arg Tyr Leu Asp Lys Asn Arg Leu Ser Pro 
        275                 280                 285             

Lys Leu Lys Ser Tyr Ile Glu Lys Gln Arg Lys Thr Ala Tyr Pro Leu 
    290                 295                 300                 

Leu Ile Phe Ala Ser Glu Ile Lys Lys Gly Glu Gln Leu Ala Glu Ile 
305                 310                 315                 320 

Leu Gln Glu Gln Phe Pro Asn Glu Lys Ile Gly Phe Val Ser Ser Val 
                325                 330                 335     

Thr Glu Asp Arg Leu Glu Gln Val Gln Ala Phe Arg Asp Gly Glu Leu 
            340                 345                 350         

Thr Ile Leu Ile Ser Thr Thr Ile Leu Glu Arg Gly Val Thr Phe Pro 
        355                 360                 365             

Cys Val Asp Val Phe Val Val Glu Ala Asn His Arg Leu Phe Thr Lys 
    370                 375                 380                 

Ser Ser Leu Ile Gln Ile Gly Gly Arg Val Gly Arg Ser Met Asp Arg 
385                 390                 395                 400 

Pro Thr Gly Asp Leu Leu Phe Phe His Asp Gly Leu Asn Ala Ser Ile 
                405                 410                 415     

Lys Lys Ala Ile Lys Glu Ile Gln Met Met Asn Lys Glu Ala Gly Leu 
            420                 425                 430         


<210>   4637
<211>   633
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4637
atggaattta ggacaattaa agaggacggt caagtccaag aagaaatcaa aaaatctcgc   60
tttatctgcc atgccaagcg tgtttatagc gaagaagagg ctcgtgactt cattactgcc   120
atcaaaaaag aacactacaa agcgacacat aactgctctg ccttcattat tggagaacgt   180
agtgaaatta aacgtacaag tgatgatggt gagcctagtg gtactgctgg tgttcccatg   240
cttggggtac tagaaaatca caatctcacc aatgtctgtg tggtcgtgac acgctacttt   300
ggtggtatta aactaggcgc tggaggacta attcgtgctt acgccggcag tgtcgcctta   360
gctgtcaaag aaattggtat tattgaaata aaagaacagg ctggcattgc tattcaaatg   420
tcttatgctc agtaccaaga gtacagtaac ttccttaaag aacatggtct catggagctg   480
gatacaaact ttacagatca agtcgatacg atgatttatg ttgataaaga agaaaaagaa   540
actattaaag ctgcacttgt ggagtttttt aatggaaaag tcactttaac tgaccaaggt   600
ttacgagagg ttgaagttcc tgtaaactta gtg                                633

<210>   4638
<211>   211
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904055 (e-118)

<400>   4638
Met Glu Phe Arg Thr Ile Lys Glu Asp Gly Gln Val Gln Glu Glu Ile 
1               5                   10                  15      

Lys Lys Ser Arg Phe Ile Cys His Ala Lys Arg Val Tyr Ser Glu Glu 
            20                  25                  30          

Glu Ala Arg Asp Phe Ile Thr Ala Ile Lys Lys Glu His Tyr Lys Ala 
        35                  40                  45              

Thr His Asn Cys Ser Ala Phe Ile Ile Gly Glu Arg Ser Glu Ile Lys 
    50                  55                  60                  

Arg Thr Ser Asp Asp Gly Glu Pro Ser Gly Thr Ala Gly Val Pro Met 
65                  70                  75                  80  

Leu Gly Val Leu Glu Asn His Asn Leu Thr Asn Val Cys Val Val Val 
                85                  90                  95      

Thr Arg Tyr Phe Gly Gly Ile Lys Leu Gly Ala Gly Gly Leu Ile Arg 
            100                 105                 110         

Ala Tyr Ala Gly Ser Val Ala Leu Ala Val Lys Glu Ile Gly Ile Ile 
        115                 120                 125             

Glu Ile Lys Glu Gln Ala Gly Ile Ala Ile Gln Met Ser Tyr Ala Gln 
    130                 135                 140                 

Tyr Gln Glu Tyr Ser Asn Phe Leu Lys Glu His Gly Leu Met Glu Leu 
145                 150                 155                 160 

Asp Thr Asn Phe Thr Asp Gln Val Asp Thr Met Ile Tyr Val Asp Lys 
                165                 170                 175     

Glu Glu Lys Glu Thr Ile Lys Ala Ala Leu Val Glu Phe Phe Asn Gly 
            180                 185                 190         

Lys Val Thr Leu Thr Asp Gln Gly Leu Arg Glu Val Glu Val Pro Val 
        195                 200                 205             

Asn Leu Val 
    210     

<210>   4639
<211>   918
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4639
atgtctattt ataacaacat tactgaatta atcggtcaaa caccgattgt taaacttaac   60
aacatcgtgc cagaaggtgc tgcagacgtc tatataaagc ttgaagcatt taatcctggt   120
tcatctgtaa aagaccgtat tgcccttagc atgattgaaa aagctgaaca agatggtatt   180
ctgaaacctg gttctactat tgttgaagca acaagtggaa acaccggtat tggactttca   240
tgggtaggtg ctgctaaagg gtataaagtc gtcatcgtta tgcctgaaac tatgagtgta   300
gaacgacgta aaattatcca agcttatggt gctgaactcg tcctaactcc tggtagcgag   360
ggaatgaaag gtgctattgc taaggctcaa gaaatcgctg ctgaacgtga tggtttcctt   420
cctcttcaat ttgacaatcc agctaatcca gaagtacacg aaagaacaac aggagctgag   480
atactagctg ctttcggtaa agatggatta gatgcctttg ttgctggagt aggtactggt   540
ggaacgattt ctggtgtttc tcatgcactc aaatcagaaa attctaacat tcaagttttt   600
gcagtagaag cagatgaatc tgctattcta tctggtgaaa aacctggtcc tcacaaaatt   660
caaggtatct cagctggatt tattcctgat acacttgata ctaaagccta tgatggtatc   720
gttcgtgtaa catcagatga cgctcttgca ctcggacgtg aaattggtgg aaaagaaggc   780
ttccttgtag ggatttcctc agctgcagct atctacggag ccatcgaggt tgccaaaaaa   840
ttaggtacag gtaaaaaagt ccttgcccta gcaccagata acggtgaacg ttatctctct   900
acagcacttt atgaattg                                                 918

<210>   4640
<211>   306
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cysteine synthase (cysM)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904056 (e-170)

<400>   4640
Met Ser Ile Tyr Asn Asn Ile Thr Glu Leu Ile Gly Gln Thr Pro Ile 
1               5                   10                  15      

Val Lys Leu Asn Asn Ile Val Pro Glu Gly Ala Ala Asp Val Tyr Ile 
            20                  25                  30          

Lys Leu Glu Ala Phe Asn Pro Gly Ser Ser Val Lys Asp Arg Ile Ala 
        35                  40                  45              

Leu Ser Met Ile Glu Lys Ala Glu Gln Asp Gly Ile Leu Lys Pro Gly 
    50                  55                  60                  

Ser Thr Ile Val Glu Ala Thr Ser Gly Asn Thr Gly Ile Gly Leu Ser 
65                  70                  75                  80  

Trp Val Gly Ala Ala Lys Gly Tyr Lys Val Val Ile Val Met Pro Glu 
                85                  90                  95      

Thr Met Ser Val Glu Arg Arg Lys Ile Ile Gln Ala Tyr Gly Ala Glu 
            100                 105                 110         

Leu Val Leu Thr Pro Gly Ser Glu Gly Met Lys Gly Ala Ile Ala Lys 
        115                 120                 125             

Ala Gln Glu Ile Ala Ala Glu Arg Asp Gly Phe Leu Pro Leu Gln Phe 
    130                 135                 140                 

Asp Asn Pro Ala Asn Pro Glu Val His Glu Arg Thr Thr Gly Ala Glu 
145                 150                 155                 160 

Ile Leu Ala Ala Phe Gly Lys Asp Gly Leu Asp Ala Phe Val Ala Gly 
                165                 170                 175     

Val Gly Thr Gly Gly Thr Ile Ser Gly Val Ser His Ala Leu Lys Ser 
            180                 185                 190         

Glu Asn Ser Asn Ile Gln Val Phe Ala Val Glu Ala Asp Glu Ser Ala 
        195                 200                 205             

Ile Leu Ser Gly Glu Lys Pro Gly Pro His Lys Ile Gln Gly Ile Ser 
    210                 215                 220                 

Ala Gly Phe Ile Pro Asp Thr Leu Asp Thr Lys Ala Tyr Asp Gly Ile 
225                 230                 235                 240 

Val Arg Val Thr Ser Asp Asp Ala Leu Ala Leu Gly Arg Glu Ile Gly 
                245                 250                 255     

Gly Lys Glu Gly Phe Leu Val Gly Ile Ser Ser Ala Ala Ala Ile Tyr 
            260                 265                 270         

Gly Ala Ile Glu Val Ala Lys Lys Leu Gly Thr Gly Lys Lys Val Leu 
        275                 280                 285             

Ala Leu Ala Pro Asp Asn Gly Glu Arg Tyr Leu Ser Thr Ala Leu Tyr 
    290                 295                 300                 

Glu Leu 
305     

<210>   4641
<211>   396
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4641
gtgaaagctc ctattcctaa agccccttta gcgcataact ttggctcagc ttctattatc   60
gctcacacca tccatcagaa gtttaatctg aaggtaccca attatcgcca agaagaagat   120
tgggctagga tgggtttacc aatcacacgt aaggaaatct ctaattggca tatcaagacg   180
agtcaatact atttggagcc cctttataac ctcttgcgag agagactatt gactcagccc   240
ttacttcatg cggatgaaac ttcttatagg gtgctagaga gtgatagtca gctgacttac   300
tattggactt ttttgtctgg gaaagctgag aaacaaggga ttacgcttta ccatcatgtt   360
ctaatcgatt tgttcatatc ttatttcaat ccatta                             396

<210>   4642
<211>   132
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf3, degenerate

<400>   4642
Met Lys Ala Pro Ile Pro Lys Ala Pro Leu Ala His Asn Phe Gly Ser 
1               5                   10                  15      

Ala Ser Ile Ile Ala His Thr Ile His Gln Lys Phe Asn Leu Lys Val 
            20                  25                  30          

Pro Asn Tyr Arg Gln Glu Glu Asp Trp Ala Arg Met Gly Leu Pro Ile 
        35                  40                  45              

Thr Arg Lys Glu Ile Ser Asn Trp His Ile Lys Thr Ser Gln Tyr Tyr 
    50                  55                  60                  

Leu Glu Pro Leu Tyr Asn Leu Leu Arg Glu Arg Leu Leu Thr Gln Pro 
65                  70                  75                  80  

Leu Leu His Ala Asp Glu Thr Ser Tyr Arg Val Leu Glu Ser Asp Ser 
                85                  90                  95      

Gln Leu Thr Tyr Tyr Trp Thr Phe Leu Ser Gly Lys Ala Glu Lys Gln 
            100                 105                 110         

Gly Ile Thr Leu Tyr His His Val Leu Ile Asp Leu Phe Ile Ser Tyr 
        115                 120                 125             

Phe Asn Pro Leu 
    130         

<210>   4643
<211>   243
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4643
atggacaatg ctatatggca taaatcaagt accttaaaga ttccgactaa tattggcttt   60
gcatttattc ctccatacac accagagatg aaccccattg aacaagtgtg gaaagagatt   120
cgtaaacgtg gatttaagaa taaagccttt cgaactttgg aagatgtcat acaaggactg   180
gagaaggagg tgataaagtc catcgttaat cggagacgga ctagaatgct ttttgaaaac   240
aga                                                                 243

<210>   4644
<211>   81
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase family protein, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902688 (6.E-40)

<400>   4644
Met Asp Asn Ala Ile Trp His Lys Ser Ser Thr Leu Lys Ile Pro Thr 
1               5                   10                  15      

Asn Ile Gly Phe Ala Phe Ile Pro Pro Tyr Thr Pro Glu Met Asn Pro 
            20                  25                  30          

Ile Glu Gln Val Trp Lys Glu Ile Arg Lys Arg Gly Phe Lys Asn Lys 
        35                  40                  45              

Ala Phe Arg Thr Leu Glu Asp Val Ile Gln Gly Leu Glu Lys Glu Val 
    50                  55                  60                  

Ile Lys Ser Ile Val Asn Arg Arg Arg Thr Arg Met Leu Phe Glu Asn 
65                  70                  75                  80  

Arg 
    

<210>   4645
<211>   321
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4645
atgataattc aactaagtga tttaggtcaa gttcaccttg tttgtggcaa gacagatatg   60
aggcagggaa tagactcatt agcctatgta gttaaaaccc actttgaatt ggatcctttc   120
tccgatcaag tctttctctt ttgtggtgga cgtaaagacc gctttaaagt tctttactgg   180
gatggtcaag gattttggat attatataaa cgctttgaga acggaaaact gacttggtcc   240
agtacagaaa aggatgtcaa agctctcgca cctgaacaag tagattggct gatgaagggc   300
ttttctatca ctccccaaat a                                             321

<210>   4646
<211>   107
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf2, interruption
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904060 (0.E+01)

<400>   4646
Met Ile Ile Gln Leu Ser Asp Leu Gly Gln Val His Leu Val Cys Gly 
1               5                   10                  15      

Lys Thr Asp Met Arg Gln Gly Ile Asp Ser Leu Ala Tyr Val Val Lys 
            20                  25                  30          

Thr His Phe Glu Leu Asp Pro Phe Ser Asp Gln Val Phe Leu Phe Cys 
        35                  40                  45              

Gly Gly Arg Lys Asp Arg Phe Lys Val Leu Tyr Trp Asp Gly Gln Gly 
    50                  55                  60                  

Phe Trp Ile Leu Tyr Lys Arg Phe Glu Asn Gly Lys Leu Thr Trp Ser 
65                  70                  75                  80  

Ser Thr Glu Lys Asp Val Lys Ala Leu Ala Pro Glu Gln Val Asp Trp 
                85                  90                  95      

Leu Met Lys Gly Phe Ser Ile Thr Pro Gln Ile 
            100                 105         

<210>   4647
<211>   1038
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4647
atggcagaaa ttacagctaa acttgtaaaa gagttgcgtg aaaaatctgg tgccggtgtt   60
atggacgcta aaaaagcgct tgtagaaaca gacggtgaca tcgaaaaagc gattgaattg   120
cttcgtgaaa aaggtatggc taaggcagct aagaaagctg accgtgttgc tgcagaaggt   180
ttgactggtg tttatgttaa cggtaatgtt gcagcagtta ttgaagtaaa cgctgaaact   240
gacttcgttg caaaaaacgc tcaattcgtt gaattggtaa atactacagc taaagtcatt   300
gctgaaggaa aacctgctaa caacgaagaa gctcttgctt tgataatgcc ttcaggtgaa   360
actcttgaag ctgcatacgt atctgcaaca gcaactatcg gagagaaaat ctcattccgt   420
cgctttgcat tgattgaaaa aacagacgca caacactttg gagcatacca acataacggt   480
ggacgtatcg gtgttatttc agttgttgaa ggtggagacg aagcacttgc taaacaattg   540
tcaatgcaca tcgcagcgat gaaaccaaca gttctttctt acaaagaatt ggatgagcaa   600
ttcgttaaag atgagttggc acaattgaat cacgttatcg accaagacaa cgaaagccgt   660
gcaatggtta ataaaccagc tcttccacac ttgaagtatg gatcaaaagc tcaattaact   720
gatgatgtta ttgctcaagc tgaagctgac atcaaagctg aattggctgc agaaggcaaa   780
ccagaaaaaa tctgggacaa aattattcca ggtaaaatgg atcgcttcat gcttgataac   840
actaaagttg accaagctta cacacttctt gcacaagttt acatcatgga tgacagcaag   900
acagttgaag cataccttga atcagttaac gcttcggtag ttgagtttgc tcgctttgaa   960
gttggtgaag gtatcgagaa agctgcaaac gacttcgaag ctgaagttgc agctacaatg   1020
gcagcagcct tgaataac                                                 1038

<210>   4648
<211>   346
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   translation elongation factor TS (tsf)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903342 (1.E-38)

<400>   4648
Met Ala Glu Ile Thr Ala Lys Leu Val Lys Glu Leu Arg Glu Lys Ser 
1               5                   10                  15      

Gly Ala Gly Val Met Asp Ala Lys Lys Ala Leu Val Glu Thr Asp Gly 
            20                  25                  30          

Asp Ile Glu Lys Ala Ile Glu Leu Leu Arg Glu Lys Gly Met Ala Lys 
        35                  40                  45              

Ala Ala Lys Lys Ala Asp Arg Val Ala Ala Glu Gly Leu Thr Gly Val 
    50                  55                  60                  

Tyr Val Asn Gly Asn Val Ala Ala Val Ile Glu Val Asn Ala Glu Thr 
65                  70                  75                  80  

Asp Phe Val Ala Lys Asn Ala Gln Phe Val Glu Leu Val Asn Thr Thr 
                85                  90                  95      

Ala Lys Val Ile Ala Glu Gly Lys Pro Ala Asn Asn Glu Glu Ala Leu 
            100                 105                 110         

Ala Leu Ile Met Pro Ser Gly Glu Thr Leu Glu Ala Ala Tyr Val Ser 
        115                 120                 125             

Ala Thr Ala Thr Ile Gly Glu Lys Ile Ser Phe Arg Arg Phe Ala Leu 
    130                 135                 140                 

Ile Glu Lys Thr Asp Ala Gln His Phe Gly Ala Tyr Gln His Asn Gly 
145                 150                 155                 160 

Gly Arg Ile Gly Val Ile Ser Val Val Glu Gly Gly Asp Glu Ala Leu 
                165                 170                 175     

Ala Lys Gln Leu Ser Met His Ile Ala Ala Met Lys Pro Thr Val Leu 
            180                 185                 190         

Ser Tyr Lys Glu Leu Asp Glu Gln Phe Val Lys Asp Glu Leu Ala Gln 
        195                 200                 205             

Leu Asn His Val Ile Asp Gln Asp Asn Glu Ser Arg Ala Met Val Asn 
    210                 215                 220                 

Lys Pro Ala Leu Pro His Leu Lys Tyr Gly Ser Lys Ala Gln Leu Thr 
225                 230                 235                 240 

Asp Asp Val Ile Ala Gln Ala Glu Ala Asp Ile Lys Ala Glu Leu Ala 
                245                 250                 255     

Ala Glu Gly Lys Pro Glu Lys Ile Trp Asp Lys Ile Ile Pro Gly Lys 
            260                 265                 270         

Met Asp Arg Phe Met Leu Asp Asn Thr Lys Val Asp Gln Ala Tyr Thr 
        275                 280                 285             

Leu Leu Ala Gln Val Tyr Ile Met Asp Asp Ser Lys Thr Val Glu Ala 
    290                 295                 300                 

Tyr Leu Glu Ser Val Asn Ala Ser Val Val Glu Phe Ala Arg Phe Glu 
305                 310                 315                 320 

Val Gly Glu Gly Ile Glu Lys Ala Ala Asn Asp Phe Glu Ala Glu Val 
                325                 330                 335     

Ala Ala Thr Met Ala Ala Ala Leu Asn Asn 
            340                 345     

<210>   4649
<211>   861
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4649
ttgatgaatt gtgaagcagt tgcccttggg tcgttttgcg agttgaagtc aagaagagga   60
aaaaaacaaa aaggagaaat actcatggca gtaatttcaa tgaaacaact tcttgaggct   120
ggtgtacact ttggtcacca aactcgtcgc tggaatccta agatggctaa gtacatcttt   180
actgaacgta acggaatcca cgttatcgac ttgcaacaaa ctgtaaaata cgctgaccaa   240
gcatacgact tcatgcgtga tgcagcagct aacgatgcag ttgtattgtt cgttggtact   300
aagaaacaag cagctgatgc agttgctgaa gaagcagtac gttcaggtca atacttcatc   360
aaccaccgtt ggttgggtgg aactcttaca aactggggaa caatccaaaa acgtatcgct   420
cgtttgaaag aaattaaacg tatggaagaa gatggaactt tcgaagttct tcctaagaaa   480
gaagttgcac ttcttaacaa acaacgtgcg cgtcttgaaa aattcttggg cggtatcgaa   540
gatatgcctc gtatcccaga tgtgatgtac gtagttgacc cacataaaga gcaaatcgct   600
gttaaagaag ctaaaaaatt gggaatccca gttgtagcga tggttgacac caatactgat   660
ccagatgata tcgatgtaat catcccagct aacgatgacg ctatccgtgc tgttaaattg   720
atcacagcta aattggctga cgctattatc gaaggacgtc aaggtgagga tgcagtagca   780
gttgaagcag aatttgcagc tttagaaact caagcagatt caattgaaga aatcgttgaa   840
gttgtagaag gcgacaacgc t                                             861

<210>   4650
<211>   287
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S2 (rpsB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904061 (e-144)

<400>   4650
Met Met Asn Cys Glu Ala Val Ala Leu Gly Ser Phe Cys Glu Leu Lys 
1               5                   10                  15      

Ser Arg Arg Gly Lys Lys Gln Lys Gly Glu Ile Leu Met Ala Val Ile 
            20                  25                  30          

Ser Met Lys Gln Leu Leu Glu Ala Gly Val His Phe Gly His Gln Thr 
        35                  40                  45              

Arg Arg Trp Asn Pro Lys Met Ala Lys Tyr Ile Phe Thr Glu Arg Asn 
    50                  55                  60                  

Gly Ile His Val Ile Asp Leu Gln Gln Thr Val Lys Tyr Ala Asp Gln 
65                  70                  75                  80  

Ala Tyr Asp Phe Met Arg Asp Ala Ala Ala Asn Asp Ala Val Val Leu 
                85                  90                  95      

Phe Val Gly Thr Lys Lys Gln Ala Ala Asp Ala Val Ala Glu Glu Ala 
            100                 105                 110         

Val Arg Ser Gly Gln Tyr Phe Ile Asn His Arg Trp Leu Gly Gly Thr 
        115                 120                 125             

Leu Thr Asn Trp Gly Thr Ile Gln Lys Arg Ile Ala Arg Leu Lys Glu 
    130                 135                 140                 

Ile Lys Arg Met Glu Glu Asp Gly Thr Phe Glu Val Leu Pro Lys Lys 
145                 150                 155                 160 

Glu Val Ala Leu Leu Asn Lys Gln Arg Ala Arg Leu Glu Lys Phe Leu 
                165                 170                 175     

Gly Gly Ile Glu Asp Met Pro Arg Ile Pro Asp Val Met Tyr Val Val 
            180                 185                 190         

Asp Pro His Lys Glu Gln Ile Ala Val Lys Glu Ala Lys Lys Leu Gly 
        195                 200                 205             

Ile Pro Val Val Ala Met Val Asp Thr Asn Thr Asp Pro Asp Asp Ile 
    210                 215                 220                 

Asp Val Ile Ile Pro Ala Asn Asp Asp Ala Ile Arg Ala Val Lys Leu 
225                 230                 235                 240 

Ile Thr Ala Lys Leu Ala Asp Ala Ile Ile Glu Gly Arg Gln Gly Glu 
                245                 250                 255     

Asp Ala Val Ala Val Glu Ala Glu Phe Ala Ala Leu Glu Thr Gln Ala 
            260                 265                 270         

Asp Ser Ile Glu Glu Ile Val Glu Val Val Glu Gly Asp Asn Ala 
        275                 280                 285         

<210>   4651
<211>   1176
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4651
atgaagaaaa aaatcttagc gtcactttta ttaagtacag taatggtttc tcaagtagct   60
gttttaacaa ctgcgcatgc agaaacgact gatgacaaaa ttgctgctca agataataaa   120
attagtaact taacagcaca acaacaagaa gcccaaaaac aagttgacca aattcaggag   180
caagtatcag ctattcaagc tgagcagtct aacttgcaag ctgaaaatga tagattacaa   240
gcagaatcta agaaactcga gggtgagatt acagaacttt ctaaaaacat tgtttctcgt   300
aaccaatcgt tggaaaaaca agctcgtagt gctcaaacaa atggagccgt aactagctat   360
atcaatacca ttgtaaactc aaaatcaatt acagaagcta tttcacgtgt tgctgcaatg   420
agtgaaatcg tatctgcaaa caacaaaatg ttagaacaac aaaaggcaga taaaaaagct   480
atttctgaaa aacaagtagc aaataatgat gctatcaata ctgtaattgc taatcaacaa   540
aaattggctg atgatgctca agcattgact acgaaacagg cagaactaaa agctgctgaa   600
ttaagtcttg ctgctgagaa agcgacagct gaaggggaaa aagcaagtct attagagcaa   660
aaagcagcag ctgaggcaga ggctcgtgca gctgcggtag cagaagcagc ttataaagaa   720
aaacgagcta gccaacaaca atcagtactt gcttcagcaa acactaactt aacagctcaa   780
gtgcaagcag tatctgaatc tgcagcagca cctgtccgtg caaaagttcg tccaacatac   840
agtacaaacg cttcaagtta tccaattgga gaatgtacat ggggagtaaa aacattggca   900
ccttgggctg gagactactg gggtaatgga gcacagtggg ctacaagtgc agcagcagca   960
ggtttccgta caggttcaac acctcaagtt ggagcaattg catgttggaa tgatggtgga   1020
tatggtcacg tagcggttgt tacagctgtt gaatcaacaa cacgtatcca agtatcagaa   1080
tcaaattatg caggtaatcg tacaattgga aatcaccgtg gatggttcaa tccaacaaca   1140
acttctgaag gttttgttac atatatttat gcagat                             1176

<210>   4652
<211>   392
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   secreted 45 kd protein (usp45)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15904062 (0.E+01)

<400>   4652
Met Lys Lys Lys Ile Leu Ala Ser Leu Leu Leu Ser Thr Val Met Val 
1               5                   10                  15      

Ser Gln Val Ala Val Leu Thr Thr Ala His Ala Glu Thr Thr Asp Asp 
            20                  25                  30          

Lys Ile Ala Ala Gln Asp Asn Lys Ile Ser Asn Leu Thr Ala Gln Gln 
        35                  40                  45              

Gln Glu Ala Gln Lys Gln Val Asp Gln Ile Gln Glu Gln Val Ser Ala 
    50                  55                  60                  

Ile Gln Ala Glu Gln Ser Asn Leu Gln Ala Glu Asn Asp Arg Leu Gln 
65                  70                  75                  80  

Ala Glu Ser Lys Lys Leu Glu Gly Glu Ile Thr Glu Leu Ser Lys Asn 
                85                  90                  95      

Ile Val Ser Arg Asn Gln Ser Leu Glu Lys Gln Ala Arg Ser Ala Gln 
            100                 105                 110         

Thr Asn Gly Ala Val Thr Ser Tyr Ile Asn Thr Ile Val Asn Ser Lys 
        115                 120                 125             

Ser Ile Thr Glu Ala Ile Ser Arg Val Ala Ala Met Ser Glu Ile Val 
    130                 135                 140                 

Ser Ala Asn Asn Lys Met Leu Glu Gln Gln Lys Ala Asp Lys Lys Ala 
145                 150                 155                 160 

Ile Ser Glu Lys Gln Val Ala Asn Asn Asp Ala Ile Asn Thr Val Ile 
                165                 170                 175     

Ala Asn Gln Gln Lys Leu Ala Asp Asp Ala Gln Ala Leu Thr Thr Lys 
            180                 185                 190         

Gln Ala Glu Leu Lys Ala Ala Glu Leu Ser Leu Ala Ala Glu Lys Ala 
        195                 200                 205             

Thr Ala Glu Gly Glu Lys Ala Ser Leu Leu Glu Gln Lys Ala Ala Ala 
    210                 215                 220                 

Glu Ala Glu Ala Arg Ala Ala Ala Val Ala Glu Ala Ala Tyr Lys Glu 
225                 230                 235                 240 

Lys Arg Ala Ser Gln Gln Gln Ser Val Leu Ala Ser Ala Asn Thr Asn 
                245                 250                 255     

Leu Thr Ala Gln Val Gln Ala Val Ser Glu Ser Ala Ala Ala Pro Val 
            260                 265                 270         

Arg Ala Lys Val Arg Pro Thr Tyr Ser Thr Asn Ala Ser Ser Tyr Pro 
        275                 280                 285             

Ile Gly Glu Cys Thr Trp Gly Val Lys Thr Leu Ala Pro Trp Ala Gly 
    290                 295                 300                 

Asp Tyr Trp Gly Asn Gly Ala Gln Trp Ala Thr Ser Ala Ala Ala Ala 
305                 310                 315                 320 

Gly Phe Arg Thr Gly Ser Thr Pro Gln Val Gly Ala Ile Ala Cys Trp 
                325                 330                 335     

Asn Asp Gly Gly Tyr Gly His Val Ala Val Val Thr Ala Val Glu Ser 
            340                 345                 350         

Thr Thr Arg Ile Gln Val Ser Glu Ser Asn Tyr Ala Gly Asn Arg Thr 
        355                 360                 365             

Ile Gly Asn His Arg Gly Trp Phe Asn Pro Thr Thr Thr Ser Glu Gly 
    370                 375                 380                 

Phe Val Thr Tyr Ile Tyr Ala Asp 
385                 390         

<210>   4653
<211>   492
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4653
atgagacagt tgaagcgagt tggagtattt ttattgcttc ctttctttgt tctaattgac   60
gcccatatta gccagcttct gggctcattt ttcccccatg tacatttggc tagtcatttt   120
ctttttctat ttctcttatt tgagacgata gaagtatcag agtatctcta cctagtctat   180
tgttttgtta taggcttggt ttatgatgtt tactttttcc atctaatagg gattacaact   240
ctcttattta tcttattggg agccttcctt cataaattga atagtgttat tttgttgaat   300
cgttggacaa gaatgctagc tatgattgtg ctgacattcc tgtttgaaat gggtagttat   360
cttttggctt ttatggtagg gttgacagta gatagcatgt cgatttttat agtctatagc   420
ttggtaccga cgatgatttt aaatttttta tggattactg tttttcaatt tatttttgaa   480
aaatattatc ta                                                       492

<210>   4654
<211>   164
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   rod shpae-determining protein MreD, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904063 (4.E-91)

<400>   4654
Met Arg Gln Leu Lys Arg Val Gly Val Phe Leu Leu Leu Pro Phe Phe 
1               5                   10                  15      

Val Leu Ile Asp Ala His Ile Ser Gln Leu Leu Gly Ser Phe Phe Pro 
            20                  25                  30          

His Val His Leu Ala Ser His Phe Leu Phe Leu Phe Leu Leu Phe Glu 
        35                  40                  45              

Thr Ile Glu Val Ser Glu Tyr Leu Tyr Leu Val Tyr Cys Phe Val Ile 
    50                  55                  60                  

Gly Leu Val Tyr Asp Val Tyr Phe Phe His Leu Ile Gly Ile Thr Thr 
65                  70                  75                  80  

Leu Leu Phe Ile Leu Leu Gly Ala Phe Leu His Lys Leu Asn Ser Val 
                85                  90                  95      

Ile Leu Leu Asn Arg Trp Thr Arg Met Leu Ala Met Ile Val Leu Thr 
            100                 105                 110         

Phe Leu Phe Glu Met Gly Ser Tyr Leu Leu Ala Phe Met Val Gly Leu 
        115                 120                 125             

Thr Val Asp Ser Met Ser Ile Phe Ile Val Tyr Ser Leu Val Pro Thr 
    130                 135                 140                 

Met Ile Leu Asn Phe Leu Trp Ile Thr Val Phe Gln Phe Ile Phe Glu 
145                 150                 155                 160 

Lys Tyr Tyr Leu 
                

<210>   4655
<211>   816
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4655
atgaaccgtt ttaaaaaatc aaaatatgtc attattgttt ttgtcactgt tctgcttgtg   60
tcagctctct tagcgacgac ttattcaagt acaattgtga caaaattagg agatggaatc   120
tcattggttg atagagttgt acaaaaacct tttcagtggt ttgattctgt caaatcagat   180
ttggctcatt tgacacgaac atataatgaa aatgaaagtt tgaagaaaca gctttaccaa   240
ttagaagtta aatcaaatga ggtggaaagt ttaaagacag aaaatgaaca actgcgccaa   300
ttgcttgata tgaagtctaa attgcaagcc acaaagactt tagcagcaga tgttattatg   360
cgttctccgg tatcttggaa gcaggagttg accttagatg caggtagatc aaaaggtgct   420
tctgagaaca tgttagctat tgcaaatggt ggcttgattg ggagtgtttc aaaagtagag   480
gagaactcta ctatagtcaa ccttctgaca aatacggaaa atgctgataa gatttctgtt   540
aaaattcaac atggctctac tacaatttat ggaattatta ttggctatga caaggaaaat   600
gacgttctta aaattagcca attaaatagt aatagcgata ttagtgcggg agataaggtg   660
actactggtg gattaggaaa ctttaacgtt gctgatattc ctgttggtga agtggttgcc   720
acaacgcata gtacagacta tttgacacga gaagtaactg ttaaattgag tgcagatact   780
cataatgtag atgtgataga attagtgggg aattca                             816

<210>   4656
<211>   272
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   rod shape-determining protein MreC (mreC)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15904064 (e-149)

<400>   4656
Met Asn Arg Phe Lys Lys Ser Lys Tyr Val Ile Ile Val Phe Val Thr 
1               5                   10                  15      

Val Leu Leu Val Ser Ala Leu Leu Ala Thr Thr Tyr Ser Ser Thr Ile 
            20                  25                  30          

Val Thr Lys Leu Gly Asp Gly Ile Ser Leu Val Asp Arg Val Val Gln 
        35                  40                  45              

Lys Pro Phe Gln Trp Phe Asp Ser Val Lys Ser Asp Leu Ala His Leu 
    50                  55                  60                  

Thr Arg Thr Tyr Asn Glu Asn Glu Ser Leu Lys Lys Gln Leu Tyr Gln 
65                  70                  75                  80  

Leu Glu Val Lys Ser Asn Glu Val Glu Ser Leu Lys Thr Glu Asn Glu 
                85                  90                  95      

Gln Leu Arg Gln Leu Leu Asp Met Lys Ser Lys Leu Gln Ala Thr Lys 
            100                 105                 110         

Thr Leu Ala Ala Asp Val Ile Met Arg Ser Pro Val Ser Trp Lys Gln 
        115                 120                 125             

Glu Leu Thr Leu Asp Ala Gly Arg Ser Lys Gly Ala Ser Glu Asn Met 
    130                 135                 140                 

Leu Ala Ile Ala Asn Gly Gly Leu Ile Gly Ser Val Ser Lys Val Glu 
145                 150                 155                 160 

Glu Asn Ser Thr Ile Val Asn Leu Leu Thr Asn Thr Glu Asn Ala Asp 
                165                 170                 175     

Lys Ile Ser Val Lys Ile Gln His Gly Ser Thr Thr Ile Tyr Gly Ile 
            180                 185                 190         

Ile Ile Gly Tyr Asp Lys Glu Asn Asp Val Leu Lys Ile Ser Gln Leu 
        195                 200                 205             

Asn Ser Asn Ser Asp Ile Ser Ala Gly Asp Lys Val Thr Thr Gly Gly 
    210                 215                 220                 

Leu Gly Asn Phe Asn Val Ala Asp Ile Pro Val Gly Glu Val Val Ala 
225                 230                 235                 240 

Thr Thr His Ser Thr Asp Tyr Leu Thr Arg Glu Val Thr Val Lys Leu 
                245                 250                 255     

Ser Ala Asp Thr His Asn Val Asp Val Ile Glu Leu Val Gly Asn Ser 
            260                 265                 270         


<210>   4657
<211>   792
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4657
atggatagta tgattttagg gcgttatatc ccaggggatt cgattgttca ccgattggat   60
ccacgtagca aattgcttgc tatgatgcta ctgattttga ttgtgttttg ggctaataac   120
cccttgacga atctgattct ttttatagcg acagggatat ttattgcctt gtcaggagta   180
tctctttcat tttttattca gggcttgaag tctatgtttt tcttgattgc cttcacaact   240
atttttcaac tatttttcat ttctaatggg aatgttttat ttgagttttc gtttgtgaga   300
atcacggatt atgctttgca acaagctggg attatttttt gtcgctttgt attgattatt   360
ttcttttcaa ctttgttaac cttaacaacc atgcctttaa gtttggcatc agctgtcgaa   420
gctttattag cacctttaaa gcgtgtgaaa gttccagttc atgaaattgg attgatgctg   480
tctatgagtt tgcgttttgt cccaaccttg atggatgata cgactcggat tatgaatgca   540
cagaaagctc gtggagtgga ttttggagaa ggaagcatcg ttcaaaaagt aaaggcgatg   600
attcccattt tgattcctct ttttgcgaca agtttaaaac gtgcagattc cttggctatc   660
gctatggaag cgcgtggcta tcagggtgga aaaggcagaa gtcaataccg acaattgaaa   720
tggactctaa aggatacgct gaccattctt gttattctcg tacttggttg ttgtttattt   780
ttcttaaaat ct                                                       792

<210>   4658
<211>   264
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein (ABC transporter)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904065 (e-145)

<400>   4658
Met Asp Ser Met Ile Leu Gly Arg Tyr Ile Pro Gly Asp Ser Ile Val 
1               5                   10                  15      

His Arg Leu Asp Pro Arg Ser Lys Leu Leu Ala Met Met Leu Leu Ile 
            20                  25                  30          

Leu Ile Val Phe Trp Ala Asn Asn Pro Leu Thr Asn Leu Ile Leu Phe 
        35                  40                  45              

Ile Ala Thr Gly Ile Phe Ile Ala Leu Ser Gly Val Ser Leu Ser Phe 
    50                  55                  60                  

Phe Ile Gln Gly Leu Lys Ser Met Phe Phe Leu Ile Ala Phe Thr Thr 
65                  70                  75                  80  

Ile Phe Gln Leu Phe Phe Ile Ser Asn Gly Asn Val Leu Phe Glu Phe 
                85                  90                  95      


Ser Phe Val Arg Ile Thr Asp Tyr Ala Leu Gln Gln Ala Gly Ile Ile 
            100                 105                 110         

Phe Cys Arg Phe Val Leu Ile Ile Phe Phe Ser Thr Leu Leu Thr Leu 
        115                 120                 125             

Thr Thr Met Pro Leu Ser Leu Ala Ser Ala Val Glu Ala Leu Leu Ala 
    130                 135                 140                 

Pro Leu Lys Arg Val Lys Val Pro Val His Glu Ile Gly Leu Met Leu 
145                 150                 155                 160 

Ser Met Ser Leu Arg Phe Val Pro Thr Leu Met Asp Asp Thr Thr Arg 
                165                 170                 175     

Ile Met Asn Ala Gln Lys Ala Arg Gly Val Asp Phe Gly Glu Gly Ser 
            180                 185                 190         

Ile Val Gln Lys Val Lys Ala Met Ile Pro Ile Leu Ile Pro Leu Phe 
        195                 200                 205             

Ala Thr Ser Leu Lys Arg Ala Asp Ser Leu Ala Ile Ala Met Glu Ala 
    210                 215                 220                 

Arg Gly Tyr Gln Gly Gly Lys Gly Arg Ser Gln Tyr Arg Gln Leu Lys 
225                 230                 235                 240 

Trp Thr Leu Lys Asp Thr Leu Thr Ile Leu Val Ile Leu Val Leu Gly 
                245                 250                 255     

Cys Cys Leu Phe Phe Leu Lys Ser 
            260                 

<210>   4659
<211>   837
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4659
atgggaattg ctctagaaaa tgtgaatttt acatatcaag aaggtactcc cttagcttca   60
gcagctttgt cggatgtttc tttgacgatt gaagatggct cttatacagc tttaattggg   120
cacacaggta gtggtaaatc aactatttta caactcttaa atggtttatt ggtgccaagt   180
caagggagtg tgagggtttt tgatacctta atcacctcga cttctaaaaa taaagatatt   240
cgtcaaatta gaaaacaggt tggcttggta tttcagtttg ctgaaaatca gatttttgaa   300
gaaacggttt tgaaggacgt tgcttttgga ccgcaaaatt ttggagtttc tgaagaagat   360
gctgtgaaga ctgcgcgtga gaaactggct ctggttggaa ttgatgaatc actttttgat   420
cgtagtccgt ttgagctgtc agggggacaa atgagacgtg ttgccattgc aggcatactt   480
gccatggagc cagctatatt agtcttagat gagccaacag ctggtctaga tcctctaggg   540
agaaaagagt tgatgaccct gttcaaaaaa ctccaccagt cagggatgac catcgtcttg   600
gtaacgcatt tgatggatga tgttgctgaa tatgcgaatc aagtctatgt aatggaaaag   660

ggacgtttag taaagggggg caaaccaagt gatgtctttc aagacgttgt ttttatggaa   720
gaagttcagt tgggagtacc taaaattacg gccttttgta aacgattggc tgatagaggc   780
gtgtcattta aacgattacc gattaagata gaggagttca aggagtcgct aaatgga      837

<210>   4660
<211>   279
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904066 (e-154)

<400>   4660
Met Gly Ile Ala Leu Glu Asn Val Asn Phe Thr Tyr Gln Glu Gly Thr 
1               5                   10                  15      

Pro Leu Ala Ser Ala Ala Leu Ser Asp Val Ser Leu Thr Ile Glu Asp 
            20                  25                  30          

Gly Ser Tyr Thr Ala Leu Ile Gly His Thr Gly Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Leu Gln Leu Leu Asn Gly Leu Leu Val Pro Ser Gln Gly Ser Val 
    50                  55                  60                  

Arg Val Phe Asp Thr Leu Ile Thr Ser Thr Ser Lys Asn Lys Asp Ile 
65                  70                  75                  80  

Arg Gln Ile Arg Lys Gln Val Gly Leu Val Phe Gln Phe Ala Glu Asn 
                85                  90                  95      

Gln Ile Phe Glu Glu Thr Val Leu Lys Asp Val Ala Phe Gly Pro Gln 
            100                 105                 110         

Asn Phe Gly Val Ser Glu Glu Asp Ala Val Lys Thr Ala Arg Glu Lys 
        115                 120                 125             

Leu Ala Leu Val Gly Ile Asp Glu Ser Leu Phe Asp Arg Ser Pro Phe 
    130                 135                 140                 

Glu Leu Ser Gly Gly Gln Met Arg Arg Val Ala Ile Ala Gly Ile Leu 
145                 150                 155                 160 

Ala Met Glu Pro Ala Ile Leu Val Leu Asp Glu Pro Thr Ala Gly Leu 
                165                 170                 175     

Asp Pro Leu Gly Arg Lys Glu Leu Met Thr Leu Phe Lys Lys Leu His 
            180                 185                 190         

Gln Ser Gly Met Thr Ile Val Leu Val Thr His Leu Met Asp Asp Val 
        195                 200                 205             

Ala Glu Tyr Ala Asn Gln Val Tyr Val Met Glu Lys Gly Arg Leu Val 
    210                 215                 220                 

Lys Gly Gly Lys Pro Ser Asp Val Phe Gln Asp Val Val Phe Met Glu 
225                 230                 235                 240 

Glu Val Gln Leu Gly Val Pro Lys Ile Thr Ala Phe Cys Lys Arg Leu 
                245                 250                 255     

Ala Asp Arg Gly Val Ser Phe Lys Arg Leu Pro Ile Lys Ile Glu Glu 
            260                 265                 270         

Phe Lys Glu Ser Leu Asn Gly 
        275                 

<210>   4661
<211>   825
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4661
atgaaatcaa taattgatgt aaaaaatctt tcttttcgct ataaagaaaa tcagaactac   60
tacgatgtga aggatattac gtttcacgtg aaacgtggag aatggctttc gattgtaggg   120
cataatggta gtggtaaatc aacgacggtt cgattaattg atggcttact ggaagcagaa   180
tccggagaga ttgtaattga tggccaacgt ttgactgagg aaaatgtttg gaatatacgt   240
cgtcaaatcg gtatggtttt tcaaaatcca gacaatcaat ttgttggagc gactgttgaa   300
gatgatgttg cttttggttt ggaaaatcag ggactttctc gtcaagaaat gaaaaagaga   360
gtggaagaag ctctggcttt agttggcatg ttggacttta aaaagagaga gccagcgcgt   420
ctatcaggtg gccaaaagca acgtgtggcc attgcaggtg ttgtagccct aagaccagct   480
attttaatct tagatgaagc aacgagtatg ttggatcctg aggggcgtag agaacttatt   540
gggacagtaa aaggaattcg aaaagactat gatatgacgg tcatttctat tacccatgat   600
ttggaagaag tcgccatgag tgatcgcgta ttggtcatga aaaaagggga aattgaatca   660
actagtagtc caagggagct tttctctcga aatgatttag atcaaattgg attagacgat   720
ccttttgcta atcaattaaa aaaatctttg agccagaatg gctatgattt acctgaaaat   780
tatttgacag aaagtgagct agaggataag ctatgggaat tgctc                   825

<210>   4662
<211>   275
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904067 (e-155)

<400>   4662
Met Lys Ser Ile Ile Asp Val Lys Asn Leu Ser Phe Arg Tyr Lys Glu 
1               5                   10                  15      


Asn Gln Asn Tyr Tyr Asp Val Lys Asp Ile Thr Phe His Val Lys Arg 
            20                  25                  30          

Gly Glu Trp Leu Ser Ile Val Gly His Asn Gly Ser Gly Lys Ser Thr 
        35                  40                  45              

Thr Val Arg Leu Ile Asp Gly Leu Leu Glu Ala Glu Ser Gly Glu Ile 
    50                  55                  60                  

Val Ile Asp Gly Gln Arg Leu Thr Glu Glu Asn Val Trp Asn Ile Arg 
65                  70                  75                  80  

Arg Gln Ile Gly Met Val Phe Gln Asn Pro Asp Asn Gln Phe Val Gly 
                85                  90                  95      

Ala Thr Val Glu Asp Asp Val Ala Phe Gly Leu Glu Asn Gln Gly Leu 
            100                 105                 110         

Ser Arg Gln Glu Met Lys Lys Arg Val Glu Glu Ala Leu Ala Leu Val 
        115                 120                 125             

Gly Met Leu Asp Phe Lys Lys Arg Glu Pro Ala Arg Leu Ser Gly Gly 
    130                 135                 140                 

Gln Lys Gln Arg Val Ala Ile Ala Gly Val Val Ala Leu Arg Pro Ala 
145                 150                 155                 160 

Ile Leu Ile Leu Asp Glu Ala Thr Ser Met Leu Asp Pro Glu Gly Arg 
                165                 170                 175     

Arg Glu Leu Ile Gly Thr Val Lys Gly Ile Arg Lys Asp Tyr Asp Met 
            180                 185                 190         

Thr Val Ile Ser Ile Thr His Asp Leu Glu Glu Val Ala Met Ser Asp 
        195                 200                 205             

Arg Val Leu Val Met Lys Lys Gly Glu Ile Glu Ser Thr Ser Ser Pro 
    210                 215                 220                 

Arg Glu Leu Phe Ser Arg Asn Asp Leu Asp Gln Ile Gly Leu Asp Asp 
225                 230                 235                 240 

Pro Phe Ala Asn Gln Leu Lys Lys Ser Leu Ser Gln Asn Gly Tyr Asp 
                245                 250                 255     

Leu Pro Glu Asn Tyr Leu Thr Glu Ser Glu Leu Glu Asp Lys Leu Trp 
            260                 265                 270         

Glu Leu Leu 
        275 

<210>   4663
<211>   543
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4663
atgaaaaaag aacaaattcc caatctctta acaataggtc gaattctctt tatacctatt   60
tttatcttta ttttaacgat aggaaattcg atagagagtc atatagttgc agctattatc   120
tttgctgttg ccagtattac cgactattta gatggatatt tagctcgtaa atggaatgtg   180
gtcagtaatt ttggtaaatt tgcagatcct atggcggata agttactagt tatgtcggct   240
tttattatgt tgattgagtt aggtatggct ccggcttgga ttgttgcagt gattatctgt   300
cgtgagttag ctgtgacagg tttaaggctt ttattggttg aaactggtgg aacaatttta   360
gcagcagcaa tgcctggaaa aattaaaact tttagtcaga tgtttgccat tattttcttg   420
ctattacatt ggactttgct tggtcaagtt ctactttatg tagccttatt tttcactatc   480
tactctggct atgactattt caagggtagt gcctatgtat ttaaagggac atttggttcg   540
aaa                                                                 543

<210>   4664
<211>   181
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (pgs
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904068 (1.E-99)

<400>   4664
Met Lys Lys Glu Gln Ile Pro Asn Leu Leu Thr Ile Gly Arg Ile Leu 
1               5                   10                  15      

Phe Ile Pro Ile Phe Ile Phe Ile Leu Thr Ile Gly Asn Ser Ile Glu 
            20                  25                  30          

Ser His Ile Val Ala Ala Ile Ile Phe Ala Val Ala Ser Ile Thr Asp 
        35                  40                  45              

Tyr Leu Asp Gly Tyr Leu Ala Arg Lys Trp Asn Val Val Ser Asn Phe 
    50                  55                  60                  

Gly Lys Phe Ala Asp Pro Met Ala Asp Lys Leu Leu Val Met Ser Ala 
65                  70                  75                  80  

Phe Ile Met Leu Ile Glu Leu Gly Met Ala Pro Ala Trp Ile Val Ala 
                85                  90                  95      

Val Ile Ile Cys Arg Glu Leu Ala Val Thr Gly Leu Arg Leu Leu Leu 
            100                 105                 110         

Val Glu Thr Gly Gly Thr Ile Leu Ala Ala Ala Met Pro Gly Lys Ile 
        115                 120                 125             

Lys Thr Phe Ser Gln Met Phe Ala Ile Ile Phe Leu Leu Leu His Trp 
    130                 135                 140                 

Thr Leu Leu Gly Gln Val Leu Leu Tyr Val Ala Leu Phe Phe Thr Ile 
145                 150                 155                 160 

Tyr Ser Gly Tyr Asp Tyr Phe Lys Gly Ser Ala Tyr Val Phe Lys Gly 
                165                 170                 175     

Thr Phe Gly Ser Lys 
            180     

<210>   4665
<211>   828
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4665
atgacaagta tgagaaaaaa aacaattgga gaggttttac gattagctag aatcaatcag   60
ggattgagtt tagatgaatt gcagaaaaag acagaaatcc agttagatat gttggaagca   120
atggaagcag acgatttcga tcaacttcca agtccttttt acacgcgttc tttcttgaaa   180
aaatatgcat gggctgttga gttagatgac caaattgttt tggatgctta tgattctggg   240
agtatgatta cttatgagga agtagatgtt gatgaagatg agttgacagg tcgtagacgt   300
tcaagtaaga aaaagaagaa aaaaacatca tttttacctt tattttattt tatccttttt   360
gctttatcga ttttaatttt tgtgacttat tatgtttgga actatattca aactcaacca   420
gaggagcctt ctctttctaa ttacagtgtg gttcaatcaa caagttcaac tagctctgtt   480
ccccactcct caagtagtag ttcttctagt atagaatcag ctataagtgt atcaggcgaa   540
ggaaatcatg tagaaatcgc ttataagaca agtaaggaaa cagttaaatt gcaattggca   600
gtttcagatg ttacaagttg ggtcagtgtt tcagaaagcg aacttgaggg cggtgtaacc   660
ttatcgccaa agaagaaaag tgcagaagca acagttgcaa ctaaaagtcc tgtaacaatt   720
acgttaggtg ttgtaaaagg tgttgatttg acagtagata atcagactgt tgatttatcg   780
aaattaacag ctcagactgg acaaatcact gtaaccttta ctaaaaat                828

<210>   4666
<211>   276
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904069 (e-152)

<400>   4666
Met Thr Ser Met Arg Lys Lys Thr Ile Gly Glu Val Leu Arg Leu Ala 
1               5                   10                  15      

Arg Ile Asn Gln Gly Leu Ser Leu Asp Glu Leu Gln Lys Lys Thr Glu 
            20                  25                  30          

Ile Gln Leu Asp Met Leu Glu Ala Met Glu Ala Asp Asp Phe Asp Gln 
        35                  40                  45              

Leu Pro Ser Pro Phe Tyr Thr Arg Ser Phe Leu Lys Lys Tyr Ala Trp 
    50                  55                  60                  

Ala Val Glu Leu Asp Asp Gln Ile Val Leu Asp Ala Tyr Asp Ser Gly 
65                  70                  75                  80  

Ser Met Ile Thr Tyr Glu Glu Val Asp Val Asp Glu Asp Glu Leu Thr 
                85                  90                  95      

Gly Arg Arg Arg Ser Ser Lys Lys Lys Lys Lys Lys Thr Ser Phe Leu 
            100                 105                 110         

Pro Leu Phe Tyr Phe Ile Leu Phe Ala Leu Ser Ile Leu Ile Phe Val 
        115                 120                 125             

Thr Tyr Tyr Val Trp Asn Tyr Ile Gln Thr Gln Pro Glu Glu Pro Ser 
    130                 135                 140                 

Leu Ser Asn Tyr Ser Val Val Gln Ser Thr Ser Ser Thr Ser Ser Val 
145                 150                 155                 160 

Pro His Ser Ser Ser Ser Ser Ser Ser Ser Ile Glu Ser Ala Ile Ser 
                165                 170                 175     

Val Ser Gly Glu Gly Asn His Val Glu Ile Ala Tyr Lys Thr Ser Lys 
            180                 185                 190         

Glu Thr Val Lys Leu Gln Leu Ala Val Ser Asp Val Thr Ser Trp Val 
        195                 200                 205             

Ser Val Ser Glu Ser Glu Leu Glu Gly Gly Val Thr Leu Ser Pro Lys 
    210                 215                 220                 

Lys Lys Ser Ala Glu Ala Thr Val Ala Thr Lys Ser Pro Val Thr Ile 
225                 230                 235                 240 

Thr Leu Gly Val Val Lys Gly Val Asp Leu Thr Val Asp Asn Gln Thr 
                245                 250                 255     

Val Asp Leu Ser Lys Leu Thr Ala Gln Thr Gly Gln Ile Thr Val Thr 
            260                 265                 270         

Phe Thr Lys Asn 
        275     

<210>   4667
<211>   1281
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4667
atgacaaagg ttgtttttga agaaaaatac tatccagctg taaaagaaat ggtttatcga   60
actcgtttgg ccaacggatt gacagttgct cttttgccta aaaaggaatt taaagaggtt   120
tacgggagtg tcactgtaca gtttggttcg gtagatacgt ttgtcacaga agttgacgga   180
gatgtaaaac aatatcctgg aggaattgct cattttcttg aacataaatt atttgagaga   240
gaagattcta gtgatttgat gtcggctttt acgagtctag gtgcagatag taatgccttt   300
acaagcttta caaaaacaaa ctatcttttt tcagcaacgg attatttttt agaaaattta   360
gatttacttg atgaattggt aacatcagca cactttactg aagcttccat tctgacagag   420
caggatatta ttcagcaaga acgagaaatg taccaagatg atccagattc gtgtttattc   480
ttttcaactt tagcgaattt gtatcctggt acacctttag caactgatat agttggaagt   540
gaggagtcca tttcccaaat caatctaact aatttgcaag aaaattttac aaagttttac   600
aaacctgtaa acatgtctct gtttttagtt ggtaattttg atgtggagcg agtacaggac   660
tattttgaaa gcaaagaact gaaagattca gattttcagg aagtagcaag agaaaagttg   720
tttttacagc ctgtaaagcc aacagatagt atgagaatgg aagtatcttc tcccaaacta   780
gcgattggag ttagaggtaa gcgagaagtt tctgaagcgg attgctatcg acatcatatt   840
ttattaaaat tattgtttgc aatgatgttt ggttggactt cggatcgttt tcaaaaatgt   900
tatgaatcag gtaaaattga tgcgtcctta tctctggaag ttgaaataac aagtcgcttt   960
cattttgtca tgttgacaat ggatacgaaa gagccagttg ctttgtctca tcaatttagg   1020
aaggctattc gtaattttac aaaggattta gatattacag aggaacattt agatattatc   1080
aaaagagaga tgtttggcga atttttcagt agcatgaact ctcttgaatt tattgcaacg   1140
caatatgatg cttttgaaaa tggtgagata atttttgatt tgccgaaaat tttacaggaa   1200
attactttag aggatgtcct tgatgctgga catcatttaa tagatgatgg tgacatagtt   1260
gattttacaa tattcccatc g                                             1281

<210>   4668
<211>   427
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidase, M16 family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904070 (0.E+01)

<400>   4668
Met Thr Lys Val Val Phe Glu Glu Lys Tyr Tyr Pro Ala Val Lys Glu 
1               5                   10                  15      

Met Val Tyr Arg Thr Arg Leu Ala Asn Gly Leu Thr Val Ala Leu Leu 
            20                  25                  30          

Pro Lys Lys Glu Phe Lys Glu Val Tyr Gly Ser Val Thr Val Gln Phe 
        35                  40                  45              

Gly Ser Val Asp Thr Phe Val Thr Glu Val Asp Gly Asp Val Lys Gln 
    50                  55                  60                  

Tyr Pro Gly Gly Ile Ala His Phe Leu Glu His Lys Leu Phe Glu Arg 
65                  70                  75                  80  

Glu Asp Ser Ser Asp Leu Met Ser Ala Phe Thr Ser Leu Gly Ala Asp 
                85                  90                  95      

Ser Asn Ala Phe Thr Ser Phe Thr Lys Thr Asn Tyr Leu Phe Ser Ala 
            100                 105                 110         

Thr Asp Tyr Phe Leu Glu Asn Leu Asp Leu Leu Asp Glu Leu Val Thr 
        115                 120                 125             

Ser Ala His Phe Thr Glu Ala Ser Ile Leu Thr Glu Gln Asp Ile Ile 
    130                 135                 140                 

Gln Gln Glu Arg Glu Met Tyr Gln Asp Asp Pro Asp Ser Cys Leu Phe 
145                 150                 155                 160 

Phe Ser Thr Leu Ala Asn Leu Tyr Pro Gly Thr Pro Leu Ala Thr Asp 
                165                 170                 175     

Ile Val Gly Ser Glu Glu Ser Ile Ser Gln Ile Asn Leu Thr Asn Leu 
            180                 185                 190         

Gln Glu Asn Phe Thr Lys Phe Tyr Lys Pro Val Asn Met Ser Leu Phe 
        195                 200                 205             

Leu Val Gly Asn Phe Asp Val Glu Arg Val Gln Asp Tyr Phe Glu Ser 
    210                 215                 220                 

Lys Glu Leu Lys Asp Ser Asp Phe Gln Glu Val Ala Arg Glu Lys Leu 
225                 230                 235                 240 

Phe Leu Gln Pro Val Lys Pro Thr Asp Ser Met Arg Met Glu Val Ser 
                245                 250                 255     

Ser Pro Lys Leu Ala Ile Gly Val Arg Gly Lys Arg Glu Val Ser Glu 
            260                 265                 270         

Ala Asp Cys Tyr Arg His His Ile Leu Leu Lys Leu Leu Phe Ala Met 
        275                 280                 285             

Met Phe Gly Trp Thr Ser Asp Arg Phe Gln Lys Cys Tyr Glu Ser Gly 
    290                 295                 300                 

Lys Ile Asp Ala Ser Leu Ser Leu Glu Val Glu Ile Thr Ser Arg Phe 
305                 310                 315                 320 

His Phe Val Met Leu Thr Met Asp Thr Lys Glu Pro Val Ala Leu Ser 
                325                 330                 335     

His Gln Phe Arg Lys Ala Ile Arg Asn Phe Thr Lys Asp Leu Asp Ile 
            340                 345                 350         

Thr Glu Glu His Leu Asp Ile Ile Lys Arg Glu Met Phe Gly Glu Phe 
        355                 360                 365             

Phe Ser Ser Met Asn Ser Leu Glu Phe Ile Ala Thr Gln Tyr Asp Ala 
    370                 375                 380                 

Phe Glu Asn Gly Glu Ile Ile Phe Asp Leu Pro Lys Ile Leu Gln Glu 
385                 390                 395                 400 

Ile Thr Leu Glu Asp Val Leu Asp Ala Gly His His Leu Ile Asp Asp 
                405                 410                 415     

Gly Asp Ile Val Asp Phe Thr Ile Phe Pro Ser 
            420                 425         

<210>   4669
<211>   1248
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4669
atggagttag tgcatggaat ttcaacacat tttatccaat caaaaaagtt taaaacaaac   60
aaaattaccg tgcgttttac cgctccatta tcccttgata cgattgcagg tcacatgttg   120
agtgcaagta tgctagagac tgctaatcag atgtacccca cttctcaaga tttgaggaga   180
cacttggcca gtctatacgg tacagatatg tcaaccaatt gtttcagaag agggcaaagc   240
cacattatag aattgacatt tacctatgtt cgtgatgagt ttttaagtag gaaaaacgtg   300
ctaacctctc agattttgga acttgtaaaa gaaactcttt tttcacccgt agtagttgat   360
aatgggtttg atccggcctt atttgaaatt gagaaaaaac aattgctagc aagtttagca   420
gctgatatgg atgattcttt ttattttgca cataaagaat tggataaatt gttttttcat   480
gatgaacgtc ttcaattgga atatagtgat ttacgaaatc gtattttagc tgaaactcca   540
caaagttctt attcttgttt ccaagaattt ttagccaatg atcgaataga tttctttttc   600
ctaggtgatt ttaatgaggt tgaaattcaa aatgtattag aatcatttgg ctttaaaggt   660
cgaaaaggag atgtgaaggt tcagtattgt caaccttatt ctaatatcct tcaggaaggt   720
atggttcgga aaaatgtggg acaatccatt ttggaattag gttatcatta ctgttctaaa   780
tatggtgatg agcaacattt acccatgatt gtaatgaatg gtttacttgg tggatttgct   840
cactctaagc tctttacaaa tgtccgtgaa aatgctggat tagcttatac catttcaagt   900
gagcttgatt tatttagtgg attcttgagg atgtatgctg gtatcaatcg agaaaatcgt   960
aaccaggctc gtaaaatgat gaataatcaa ctgcttgatt taaaaaaagg ttattttaca   1020
gagtttgagt taaatcagac caaggaaatg attcgttggt cgttgttact ttctcaagat   1080
aatcaatctt cattgattga acgtgcttat caaaatgcct tatttggaaa atcttcagca   1140
gactttaaaa gttggattgc aaagcttgaa caaattgaca aagatgctat ttgtagagta   1200
gctaataatg tgaaactaca agcgatttac tttatggaag gaatagaa                1248

<210>   4670
<211>   416
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904071 (0.E+01)

<400>   4670
Met Glu Leu Val His Gly Ile Ser Thr His Phe Ile Gln Ser Lys Lys 
1               5                   10                  15      

Phe Lys Thr Asn Lys Ile Thr Val Arg Phe Thr Ala Pro Leu Ser Leu 
            20                  25                  30          

Asp Thr Ile Ala Gly His Met Leu Ser Ala Ser Met Leu Glu Thr Ala 
        35                  40                  45              

Asn Gln Met Tyr Pro Thr Ser Gln Asp Leu Arg Arg His Leu Ala Ser 
    50                  55                  60                  

Leu Tyr Gly Thr Asp Met Ser Thr Asn Cys Phe Arg Arg Gly Gln Ser 
65                  70                  75                  80  

His Ile Ile Glu Leu Thr Phe Thr Tyr Val Arg Asp Glu Phe Leu Ser 
                85                  90                  95      

Arg Lys Asn Val Leu Thr Ser Gln Ile Leu Glu Leu Val Lys Glu Thr 
            100                 105                 110         


Leu Phe Ser Pro Val Val Val Asp Asn Gly Phe Asp Pro Ala Leu Phe 
        115                 120                 125             

Glu Ile Glu Lys Lys Gln Leu Leu Ala Ser Leu Ala Ala Asp Met Asp 
    130                 135                 140                 

Asp Ser Phe Tyr Phe Ala His Lys Glu Leu Asp Lys Leu Phe Phe His 
145                 150                 155                 160 

Asp Glu Arg Leu Gln Leu Glu Tyr Ser Asp Leu Arg Asn Arg Ile Leu 
                165                 170                 175     

Ala Glu Thr Pro Gln Ser Ser Tyr Ser Cys Phe Gln Glu Phe Leu Ala 
            180                 185                 190         

Asn Asp Arg Ile Asp Phe Phe Phe Leu Gly Asp Phe Asn Glu Val Glu 
        195                 200                 205             

Ile Gln Asn Val Leu Glu Ser Phe Gly Phe Lys Gly Arg Lys Gly Asp 
    210                 215                 220                 

Val Lys Val Gln Tyr Cys Gln Pro Tyr Ser Asn Ile Leu Gln Glu Gly 
225                 230                 235                 240 

Met Val Arg Lys Asn Val Gly Gln Ser Ile Leu Glu Leu Gly Tyr His 
                245                 250                 255     

Tyr Cys Ser Lys Tyr Gly Asp Glu Gln His Leu Pro Met Ile Val Met 
            260                 265                 270         

Asn Gly Leu Leu Gly Gly Phe Ala His Ser Lys Leu Phe Thr Asn Val 
        275                 280                 285             

Arg Glu Asn Ala Gly Leu Ala Tyr Thr Ile Ser Ser Glu Leu Asp Leu 
    290                 295                 300                 

Phe Ser Gly Phe Leu Arg Met Tyr Ala Gly Ile Asn Arg Glu Asn Arg 
305                 310                 315                 320 

Asn Gln Ala Arg Lys Met Met Asn Asn Gln Leu Leu Asp Leu Lys Lys 
                325                 330                 335     

Gly Tyr Phe Thr Glu Phe Glu Leu Asn Gln Thr Lys Glu Met Ile Arg 
            340                 345                 350         

Trp Ser Leu Leu Leu Ser Gln Asp Asn Gln Ser Ser Leu Ile Glu Arg 
        355                 360                 365             

Ala Tyr Gln Asn Ala Leu Phe Gly Lys Ser Ser Ala Asp Phe Lys Ser 
    370                 375                 380                 

Trp Ile Ala Lys Leu Glu Gln Ile Asp Lys Asp Ala Ile Cys Arg Val 
385                 390                 395                 400 

Ala Asn Asn Val Lys Leu Gln Ala Ile Tyr Phe Met Glu Gly Ile Glu 
                405                 410                 415     


<210>   4671
<211>   366
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4671
atggaataca aattatttga agaatttatt accctccaag cactattcaa agaacttgga   60
attacacata gcggaggagc tattaaatca tttctctctg aacattctgt ttactttaat   120
agggaattag agagccgtcg tggaaaaaaa cttcgtattg gcgataaagt tgacatccct   180
gacatgaaca ttgacatctt gttgacacaa cctacttctg aagaacaaga tgaataccaa   240
gctgataaag ttgaaaaaga acggatcgct aaacttgtca aaaagatgaa taagggagtt   300
aaaaaagaca aatcgaaacc tgcttcatca cctaaaagcc aacaagctcc acgattccct   360
ggtaga                                                              366

<210>   4672
<211>   122
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904072 (2.E-65)

<400>   4672
Met Glu Tyr Lys Leu Phe Glu Glu Phe Ile Thr Leu Gln Ala Leu Phe 
1               5                   10                  15      

Lys Glu Leu Gly Ile Thr His Ser Gly Gly Ala Ile Lys Ser Phe Leu 
            20                  25                  30          

Ser Glu His Ser Val Tyr Phe Asn Arg Glu Leu Glu Ser Arg Arg Gly 
        35                  40                  45              

Lys Lys Leu Arg Ile Gly Asp Lys Val Asp Ile Pro Asp Met Asn Ile 
    50                  55                  60                  

Asp Ile Leu Leu Thr Gln Pro Thr Ser Glu Glu Gln Asp Glu Tyr Gln 
65                  70                  75                  80  

Ala Asp Lys Val Glu Lys Glu Arg Ile Ala Lys Leu Val Lys Lys Met 
                85                  90                  95      

Asn Lys Gly Val Lys Lys Asp Lys Ser Lys Pro Ala Ser Ser Pro Lys 
            100                 105                 110         

Ser Gln Gln Ala Pro Arg Phe Pro Gly Arg 
        115                 120         

<210>   4673
<211>   1095
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4673
atgtggctac aacatctatc tctcaagact tttcgtaatt acaaagaaac gaaaatagac   60
tttaatccta aattgaatgt ctttttggga cgtaatgcac aaggaaaaac aaacatgtta   120
gaggctatct attttttagc cttaacgcgt agtcatcgaa ctcgaacaga taaaaatctc   180
attcattttg atgaggaaca acttcatctt tcaggtctcg ttcagaaaaa aactggatcc   240
attcccctag aaatcgaact aacacaaaaa ggtcgtgtaa caaaagttaa tcacttaaaa   300
caggcacgcc tttcagatta tgtaggacac atgaatgttg tcttatttgc tcctgaagat   360
ttacaactaa ttaaaggagc accttcgatt cgacgaaaat tcattgatat ggaacttggg   420
caaattaagc caatctattt atctgactta accaattata accacatcct aaagcaaaga   480
aacacttacc taaaatcagc tcaaaaaata gatgaaacat tcctttctgt gttagatgat   540
cagctagttg attatggatg tcgtgtaatg aatcaccgct tagatttcat aaaaaaacta   600
gaatcatttg ggcgtaagaa acattttgaa ctctctaatc agatcgaaga gttgtcaata   660
tcctatcaat cttctgtcaa tataactgac aaacaaaact tatccgaatc tttcaaaatt   720
gctttagaaa aaagtagatc cagagattta tttaaaaaga atactggtgt cggtcctcat   780
cgagatgaca tttcttttta tataaatggg atggatgcta gtttcggaag ccaaggtcaa   840
catcgtagtc tcgtcctctc gataaaatta gcagaaatcg aattaatgga aagcattacc   900
acagaatctc ctatattact gcttgacgat gtgatgagtg aacttgacaa cactagacag   960
ttaaaattat tagaaacgat ttctcaatca atccaaacct ttatcacaac aacaagctta   1020
gaccatcttc aaaatctgcc agaaaatcta agtatcttca ctattcagga tggtaaagct   1080
gctgtaaatg gaaat                                                    1095

<210>   4674
<211>   365
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   recF protein (recF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904073 (0.E+01)

<400>   4674
Met Trp Leu Gln His Leu Ser Leu Lys Thr Phe Arg Asn Tyr Lys Glu 
1               5                   10                  15      

Thr Lys Ile Asp Phe Asn Pro Lys Leu Asn Val Phe Leu Gly Arg Asn 
            20                  25                  30          

Ala Gln Gly Lys Thr Asn Met Leu Glu Ala Ile Tyr Phe Leu Ala Leu 
        35                  40                  45              

Thr Arg Ser His Arg Thr Arg Thr Asp Lys Asn Leu Ile His Phe Asp 
    50                  55                  60                  

Glu Glu Gln Leu His Leu Ser Gly Leu Val Gln Lys Lys Thr Gly Ser 
65                  70                  75                  80  

Ile Pro Leu Glu Ile Glu Leu Thr Gln Lys Gly Arg Val Thr Lys Val 
                85                  90                  95      

Asn His Leu Lys Gln Ala Arg Leu Ser Asp Tyr Val Gly His Met Asn 
            100                 105                 110         

Val Val Leu Phe Ala Pro Glu Asp Leu Gln Leu Ile Lys Gly Ala Pro 
        115                 120                 125             

Ser Ile Arg Arg Lys Phe Ile Asp Met Glu Leu Gly Gln Ile Lys Pro 
    130                 135                 140                 

Ile Tyr Leu Ser Asp Leu Thr Asn Tyr Asn His Ile Leu Lys Gln Arg 
145                 150                 155                 160 

Asn Thr Tyr Leu Lys Ser Ala Gln Lys Ile Asp Glu Thr Phe Leu Ser 
                165                 170                 175     

Val Leu Asp Asp Gln Leu Val Asp Tyr Gly Cys Arg Val Met Asn His 
            180                 185                 190         

Arg Leu Asp Phe Ile Lys Lys Leu Glu Ser Phe Gly Arg Lys Lys His 
        195                 200                 205             

Phe Glu Leu Ser Asn Gln Ile Glu Glu Leu Ser Ile Ser Tyr Gln Ser 
    210                 215                 220                 

Ser Val Asn Ile Thr Asp Lys Gln Asn Leu Ser Glu Ser Phe Lys Ile 
225                 230                 235                 240 

Ala Leu Glu Lys Ser Arg Ser Arg Asp Leu Phe Lys Lys Asn Thr Gly 
                245                 250                 255     

Val Gly Pro His Arg Asp Asp Ile Ser Phe Tyr Ile Asn Gly Met Asp 
            260                 265                 270         

Ala Ser Phe Gly Ser Gln Gly Gln His Arg Ser Leu Val Leu Ser Ile 
        275                 280                 285             

Lys Leu Ala Glu Ile Glu Leu Met Glu Ser Ile Thr Thr Glu Ser Pro 
    290                 295                 300                 

Ile Leu Leu Leu Asp Asp Val Met Ser Glu Leu Asp Asn Thr Arg Gln 
305                 310                 315                 320 

Leu Lys Leu Leu Glu Thr Ile Ser Gln Ser Ile Gln Thr Phe Ile Thr 
                325                 330                 335     

Thr Thr Ser Leu Asp His Leu Gln Asn Leu Pro Glu Asn Leu Ser Ile 
            340                 345                 350         

Phe Thr Ile Gln Asp Gly Lys Ala Ala Val Asn Gly Asn 
        355                 360                 365 

<210>   4675
<211>   1476
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4675
atgtctaatt gggacactaa atttttgaaa aaaggtttta cctttgatga tgtattgctt   60
attccagctg aaagtcatgt gttgcctaac gatgcagatt taacaactaa attggcagat   120
aatttgactt taaatatccc aattattacc gctgccatgg acacagttac agagagtcaa   180
atggccattg ctattgctcg tgcaggcggt ctcggagtta tccataaaaa catgtcaatt   240
gctcaacaag cagacgaggt tcgtaaggta aaacgttctg aaaatggagt tattattgat   300
ccgttcttct tgacgcctga acatacaatt gctgaagcag atgagcttat gggtcgttac   360
cgcatcagtg gtgttccagt tgttgaaaca cttgaaaatc gtaaattggt tggtattttg   420
acaaaccgag atcttcgttt tatttcagat tataatcaac caatttcaaa ccatatgact   480
agtgaaaatc ttgttactgc tcctgtgggt acggatcttg caacggctga gagtattctt   540

caagagcatc gtattgaaaa acttccgttg gtcgatgaag aaggcagtct ttctggtttg   600
atcactatca aagatattga aaaagttatt gagtttccaa atgcggctaa agatgagttt   660
ggtcgtcttc tagttgcagg tgcagtaggt gttacttcag atacatttga acgtgcagag   720
gctctttttg aggcaggagc ggatgcgatt gttattgata ctgcacatgg tcattctgca   780
ggtgtcttgc gtaaaattgc cgagattcgt gctcatttcc cagatcggac tttgattgct   840
ggaaatattg ctactgctga aggtgcacgt gccctttatg aagcgggtgt agacgttgtt   900
aaggttggta ttggaccagg ttctatctgt actactcgtg tgattgctgg tgttggtgtt   960
ccgcaagtaa cagctatcta cgatgctgca gctgttgcgc gcgaatatgg taaaacgatt   1020
attgctgacg gtgggatcaa gtattctgga gatattgtaa aagcacttgc tgcaggtgga   1080
aatgctgtta tgcttggatc tatgtttgct ggaactgatg aagctccagg cgaaactgaa   1140
atcttccaag gacgtaaatt caagacttac cgtggtatgg gatcaattgc tgctatgaag   1200
aaaggttcaa gcgaccgtta tttccaaggt tctgtcaatg aagcaaacaa gcttgttcca   1260
gaaggaattg aaggtcgtgt tgcttataaa ggagcggcag ctgatattgt tttccaaatg   1320
attggtggta ttcgctctgg tatgggttac tgtggtgcag ctaaccttaa agaactacac   1380
gataatgctc aatttattga aatgtctggt gctggtttga aagaaagcca tcctcatgat   1440
gtgcaaatta ctaatgaggc accaaattat tctatg                             1476

<210>   4676
<211>   492
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   inosine-5'-monophosphate dehydrogenase (guaB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904074 (0.E+01)

<400>   4676
Met Ser Asn Trp Asp Thr Lys Phe Leu Lys Lys Gly Phe Thr Phe Asp 
1               5                   10                  15      

Asp Val Leu Leu Ile Pro Ala Glu Ser His Val Leu Pro Asn Asp Ala 
            20                  25                  30          

Asp Leu Thr Thr Lys Leu Ala Asp Asn Leu Thr Leu Asn Ile Pro Ile 
        35                  40                  45              

Ile Thr Ala Ala Met Asp Thr Val Thr Glu Ser Gln Met Ala Ile Ala 
    50                  55                  60                  

Ile Ala Arg Ala Gly Gly Leu Gly Val Ile His Lys Asn Met Ser Ile 
65                  70                  75                  80  

Ala Gln Gln Ala Asp Glu Val Arg Lys Val Lys Arg Ser Glu Asn Gly 
                85                  90                  95      

Val Ile Ile Asp Pro Phe Phe Leu Thr Pro Glu His Thr Ile Ala Glu 
            100                 105                 110         

Ala Asp Glu Leu Met Gly Arg Tyr Arg Ile Ser Gly Val Pro Val Val 
        115                 120                 125             

Glu Thr Leu Glu Asn Arg Lys Leu Val Gly Ile Leu Thr Asn Arg Asp 
    130                 135                 140                 

Leu Arg Phe Ile Ser Asp Tyr Asn Gln Pro Ile Ser Asn His Met Thr 
145                 150                 155                 160 

Ser Glu Asn Leu Val Thr Ala Pro Val Gly Thr Asp Leu Ala Thr Ala 
                165                 170                 175     

Glu Ser Ile Leu Gln Glu His Arg Ile Glu Lys Leu Pro Leu Val Asp 
            180                 185                 190         

Glu Glu Gly Ser Leu Ser Gly Leu Ile Thr Ile Lys Asp Ile Glu Lys 
        195                 200                 205             

Val Ile Glu Phe Pro Asn Ala Ala Lys Asp Glu Phe Gly Arg Leu Leu 
    210                 215                 220                 

Val Ala Gly Ala Val Gly Val Thr Ser Asp Thr Phe Glu Arg Ala Glu 
225                 230                 235                 240 

Ala Leu Phe Glu Ala Gly Ala Asp Ala Ile Val Ile Asp Thr Ala His 
                245                 250                 255     

Gly His Ser Ala Gly Val Leu Arg Lys Ile Ala Glu Ile Arg Ala His 
            260                 265                 270         

Phe Pro Asp Arg Thr Leu Ile Ala Gly Asn Ile Ala Thr Ala Glu Gly 
        275                 280                 285             

Ala Arg Ala Leu Tyr Glu Ala Gly Val Asp Val Val Lys Val Gly Ile 
    290                 295                 300                 

Gly Pro Gly Ser Ile Cys Thr Thr Arg Val Ile Ala Gly Val Gly Val 
305                 310                 315                 320 

Pro Gln Val Thr Ala Ile Tyr Asp Ala Ala Ala Val Ala Arg Glu Tyr 
                325                 330                 335     

Gly Lys Thr Ile Ile Ala Asp Gly Gly Ile Lys Tyr Ser Gly Asp Ile 
            340                 345                 350         

Val Lys Ala Leu Ala Ala Gly Gly Asn Ala Val Met Leu Gly Ser Met 
        355                 360                 365             

Phe Ala Gly Thr Asp Glu Ala Pro Gly Glu Thr Glu Ile Phe Gln Gly 
    370                 375                 380                 

Arg Lys Phe Lys Thr Tyr Arg Gly Met Gly Ser Ile Ala Ala Met Lys 
385                 390                 395                 400 

Lys Gly Ser Ser Asp Arg Tyr Phe Gln Gly Ser Val Asn Glu Ala Asn 
                405                 410                 415     

Lys Leu Val Pro Glu Gly Ile Glu Gly Arg Val Ala Tyr Lys Gly Ala 
            420                 425                 430         

Ala Ala Asp Ile Val Phe Gln Met Ile Gly Gly Ile Arg Ser Gly Met 
        435                 440                 445             

Gly Tyr Cys Gly Ala Ala Asn Leu Lys Glu Leu His Asp Asn Ala Gln 
    450                 455                 460                 

Phe Ile Glu Met Ser Gly Ala Gly Leu Lys Glu Ser His Pro His Asp 
465                 470                 475                 480 

Val Gln Ile Thr Asn Glu Ala Pro Asn Tyr Ser Met 
                485                 490         

<210>   4677
<211>   1023
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4677
atgactaaac ccattatttt aacaggagac cgtccaacag gaaaattgca tattggacat   60
tatgttggaa gtctcaaaaa tcgagtatta ttacaggaag aggataagta tgatatgttt   120
gtgttcttgg ctgaccaaca agccttgaca gatcatgcca aagatcctca aaccattgta   180
gagtctatcg gaaatgtggc tttggattat cttgcagttg gattggatcc aaataagtca   240
actattttta ttcaaagcca gattccagag ttggctgagt tgtctatgta ttatatgaat   300
ctagtttcgt tagcacgttt ggagcgaaat ccaacagtca agacagagat ttctcagaaa   360
ggatttggag aaagcattcc gacaggattc ttggtctatc caatcgctca agcagctgat   420
atcacagctt tcaaggctaa ttatgttcct gttgggacag atcagaaacc aatgattgag   480
caaactcgtg aaattgttcg ttcttttaac aatgcatata actgtgatgt cttggtagag   540
ccggaaggta tttatccaga aaatgagaga gcagggcgtt tgcctggttt agatggaaat   600
gctaaaatgt ctaaatcact aaataatggt atttatttag ctgatgatgc ggatactttg   660
cgtaaaaaag taatgagtat gtatacagat ccagatcata tccgcgttga ggatccaggt   720
aagattgagg gaaatatggt tttccattat ctagatgttt ttggtcgtcc agaagatgct   780
caagaaattg ctgatatgaa agaacgttat caacgaggtg gtcttggtga tgtgaagacc   840
aagcgttatc tacttgaaat attagaacgt gaactgggtc ctattcgtga gcgccgtatt   900
gaatttgcta aggatatggg agaagtttat aatatgattc aaaaaggtag tgaaagagcg   960
cgtgaagttg cgggtcaaac cctatctgag gtaaaagggg caatgggact tcattacttt   1020
aac                                                                 1023

<210>   4678
<211>   341
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   tryptophanyl-tRNA synthetase (trps)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904075 (0.E+01)

<400>   4678
Met Thr Lys Pro Ile Ile Leu Thr Gly Asp Arg Pro Thr Gly Lys Leu 
1               5                   10                  15      

His Ile Gly His Tyr Val Gly Ser Leu Lys Asn Arg Val Leu Leu Gln 
            20                  25                  30          

Glu Glu Asp Lys Tyr Asp Met Phe Val Phe Leu Ala Asp Gln Gln Ala 
        35                  40                  45              

Leu Thr Asp His Ala Lys Asp Pro Gln Thr Ile Val Glu Ser Ile Gly 
    50                  55                  60                  

Asn Val Ala Leu Asp Tyr Leu Ala Val Gly Leu Asp Pro Asn Lys Ser 
65                  70                  75                  80  

Thr Ile Phe Ile Gln Ser Gln Ile Pro Glu Leu Ala Glu Leu Ser Met 
                85                  90                  95      

Tyr Tyr Met Asn Leu Val Ser Leu Ala Arg Leu Glu Arg Asn Pro Thr 
            100                 105                 110         

Val Lys Thr Glu Ile Ser Gln Lys Gly Phe Gly Glu Ser Ile Pro Thr 
        115                 120                 125             

Gly Phe Leu Val Tyr Pro Ile Ala Gln Ala Ala Asp Ile Thr Ala Phe 
    130                 135                 140                 

Lys Ala Asn Tyr Val Pro Val Gly Thr Asp Gln Lys Pro Met Ile Glu 
145                 150                 155                 160 

Gln Thr Arg Glu Ile Val Arg Ser Phe Asn Asn Ala Tyr Asn Cys Asp 
                165                 170                 175     

Val Leu Val Glu Pro Glu Gly Ile Tyr Pro Glu Asn Glu Arg Ala Gly 
            180                 185                 190         

Arg Leu Pro Gly Leu Asp Gly Asn Ala Lys Met Ser Lys Ser Leu Asn 
        195                 200                 205             

Asn Gly Ile Tyr Leu Ala Asp Asp Ala Asp Thr Leu Arg Lys Lys Val 
    210                 215                 220                 

Met Ser Met Tyr Thr Asp Pro Asp His Ile Arg Val Glu Asp Pro Gly 
225                 230                 235                 240 

Lys Ile Glu Gly Asn Met Val Phe His Tyr Leu Asp Val Phe Gly Arg 
                245                 250                 255     

Pro Glu Asp Ala Gln Glu Ile Ala Asp Met Lys Glu Arg Tyr Gln Arg 
            260                 265                 270         

Gly Gly Leu Gly Asp Val Lys Thr Lys Arg Tyr Leu Leu Glu Ile Leu 
        275                 280                 285             

Glu Arg Glu Leu Gly Pro Ile Arg Glu Arg Arg Ile Glu Phe Ala Lys 
    290                 295                 300                 

Asp Met Gly Glu Val Tyr Asn Met Ile Gln Lys Gly Ser Glu Arg Ala 
305                 310                 315                 320 

Arg Glu Val Ala Gly Gln Thr Leu Ser Glu Val Lys Gly Ala Met Gly 
                325                 330                 335     

Leu His Tyr Phe Asn 
            340     

<210>   4679
<211>   1620
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4679
ttgcttacag tatctgatgt ttcactacgt tttagtgatc gcaaactttt tgatgatgtc   60
aatatcaaat ttacagaagg aaatacttac ggattaatcg gtgctaatgg tgccggaaaa   120
tcaacctttt taaaaatttt agctggagat atcgaaccta ctactggtca catctctctt   180
ggtccagatg aacgtctctc tgttcttcgt caaaatcact ttgactacga agatgaacgt   240
gccattgatg tcgttatcat gggaaatgaa aaactttata gcatcatgaa agagaaagat   300
gctatctaca tgaaggaaga tttctcagac gaggacgggg ttcgtgctgc cgaactcgaa   360
ggagagtttg ccgaacttgg aggttgggaa gcagagagtg aagcctctca actacttcaa   420
aacctaaaca ttccagaaga attacactac caaaacatga gcgaattggc caacggtgaa   480
aaagtaaagg ttctcctcgc caaagcactt tttggtaaac cagatgttct tctcttggac   540
gagcctacta acggtttgga tatccaatcg attacttggt tagaagactt cttgattgac   600
tttgataaca cagttatcgt agtatcccac gaccgtcact tcttaaacaa agtttgtact   660
cacatggccg accttgactt tggaaaaatc aaactctatg tcggaaacta cgacttctgg   720
aaggaatctt ctgagcttgc tgctaaattg ctagcagacc gtaatgctaa agcagaagaa   780
aaaattaaac aattgcaaga atttgttgct cgtttctctg ccaatgcttc taagtcaagg   840
caggcaacat cacgtaagaa aatgcttgat aagattgagc tagaagagat tgtgccatct   900
agtcgtaaat atccatttat caactttaaa gcggaacgtg agattggtaa tgatctcttg   960
acagtagaaa atttaactgt aaagattgat ggtgaaacta tcttggataa tattagtttc   1020
atcttgcgtc cagatgataa gacagcactt attggacaaa atgatattca aacgactgca   1080
ttaattcgtg caatcatggg agatattgac tatgaaggaa ctgtcaagtg gggagttaca   1140
actagtcaat cttacctacc aaaagataac tcagctgatt ttgcaggagg agaatcaatt   1200
cttgactggt tgcgtcaatt cgcaagtaaa gaagaagatg acaatacttt cctacgtggc   1260
ttcctcggcc gtatgctctt ctctggagat gaagttaaca aacctgtaaa tgtcttgtca   1320
gggggagaaa aagttcgtgt catgctttca aaactcatgc tcttaaaatc aaatgtcctt   1380
gtacttgatg atccaacaaa tcacttggac ttggaatcta tctcaagctt gaatgatgga   1440
ttgaaaaact ttaaagaatc aatcatcttt gccagccatg accacgaatt tattcaaact   1500
ttggctaacc atatcattgt cttatctaaa aatggcgtca ttgaccgtat cgatgaaacc   1560
tacgatgaat tcctagaaaa tgcagaagta caagcaaaag ttaaagaact ttggaaagac   1620

<210>   4680
<211>   540
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, ATP-binding protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904076 (0.E+01)

<400>   4680
Met Leu Thr Val Ser Asp Val Ser Leu Arg Phe Ser Asp Arg Lys Leu 
1               5                   10                  15      

Phe Asp Asp Val Asn Ile Lys Phe Thr Glu Gly Asn Thr Tyr Gly Leu 
            20                  25                  30          

Ile Gly Ala Asn Gly Ala Gly Lys Ser Thr Phe Leu Lys Ile Leu Ala 
        35                  40                  45              

Gly Asp Ile Glu Pro Thr Thr Gly His Ile Ser Leu Gly Pro Asp Glu 
    50                  55                  60                  

Arg Leu Ser Val Leu Arg Gln Asn His Phe Asp Tyr Glu Asp Glu Arg 
65                  70                  75                  80  

Ala Ile Asp Val Val Ile Met Gly Asn Glu Lys Leu Tyr Ser Ile Met 
                85                  90                  95      

Lys Glu Lys Asp Ala Ile Tyr Met Lys Glu Asp Phe Ser Asp Glu Asp 
            100                 105                 110         

Gly Val Arg Ala Ala Glu Leu Glu Gly Glu Phe Ala Glu Leu Gly Gly 
        115                 120                 125             

Trp Glu Ala Glu Ser Glu Ala Ser Gln Leu Leu Gln Asn Leu Asn Ile 
    130                 135                 140                 

Pro Glu Glu Leu His Tyr Gln Asn Met Ser Glu Leu Ala Asn Gly Glu 
145                 150                 155                 160 

Lys Val Lys Val Leu Leu Ala Lys Ala Leu Phe Gly Lys Pro Asp Val 
                165                 170                 175     

Leu Leu Leu Asp Glu Pro Thr Asn Gly Leu Asp Ile Gln Ser Ile Thr 
            180                 185                 190         

Trp Leu Glu Asp Phe Leu Ile Asp Phe Asp Asn Thr Val Ile Val Val 
        195                 200                 205             

Ser His Asp Arg His Phe Leu Asn Lys Val Cys Thr His Met Ala Asp 
    210                 215                 220                 

Leu Asp Phe Gly Lys Ile Lys Leu Tyr Val Gly Asn Tyr Asp Phe Trp 
225                 230                 235                 240 

Lys Glu Ser Ser Glu Leu Ala Ala Lys Leu Leu Ala Asp Arg Asn Ala 
                245                 250                 255     

Lys Ala Glu Glu Lys Ile Lys Gln Leu Gln Glu Phe Val Ala Arg Phe 
            260                 265                 270         

Ser Ala Asn Ala Ser Lys Ser Arg Gln Ala Thr Ser Arg Lys Lys Met 
        275                 280                 285             

Leu Asp Lys Ile Glu Leu Glu Glu Ile Val Pro Ser Ser Arg Lys Tyr 
    290                 295                 300                 

Pro Phe Ile Asn Phe Lys Ala Glu Arg Glu Ile Gly Asn Asp Leu Leu 
305                 310                 315                 320 

Thr Val Glu Asn Leu Thr Val Lys Ile Asp Gly Glu Thr Ile Leu Asp 
                325                 330                 335     

Asn Ile Ser Phe Ile Leu Arg Pro Asp Asp Lys Thr Ala Leu Ile Gly 
            340                 345                 350         

Gln Asn Asp Ile Gln Thr Thr Ala Leu Ile Arg Ala Ile Met Gly Asp 
        355                 360                 365             

Ile Asp Tyr Glu Gly Thr Val Lys Trp Gly Val Thr Thr Ser Gln Ser 
    370                 375                 380                 

Tyr Leu Pro Lys Asp Asn Ser Ala Asp Phe Ala Gly Gly Glu Ser Ile 
385                 390                 395                 400 

Leu Asp Trp Leu Arg Gln Phe Ala Ser Lys Glu Glu Asp Asp Asn Thr 
                405                 410                 415     

Phe Leu Arg Gly Phe Leu Gly Arg Met Leu Phe Ser Gly Asp Glu Val 
            420                 425                 430         

Asn Lys Pro Val Asn Val Leu Ser Gly Gly Glu Lys Val Arg Val Met 
        435                 440                 445             

Leu Ser Lys Leu Met Leu Leu Lys Ser Asn Val Leu Val Leu Asp Asp 
    450                 455                 460                 

Pro Thr Asn His Leu Asp Leu Glu Ser Ile Ser Ser Leu Asn Asp Gly 
465                 470                 475                 480 

Leu Lys Asn Phe Lys Glu Ser Ile Ile Phe Ala Ser His Asp His Glu 
                485                 490                 495     

Phe Ile Gln Thr Leu Ala Asn His Ile Ile Val Leu Ser Lys Asn Gly 
            500                 505                 510         

Val Ile Asp Arg Ile Asp Glu Thr Tyr Asp Glu Phe Leu Glu Asn Ala 
        515                 520                 525             

Glu Val Gln Ala Lys Val Lys Glu Leu Trp Lys Asp 
    530                 535                 540 

<210>   4681
<211>   2550
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4681
atgaaatcat ttttaaaaac atatcgaacc tattttattt ctttcatcat tcctgtagtg   60
attatgtctg gagtatatct atctcaaagt atctactgga atagcgacaa ctctcctcta   120
ttaggagatg gctttcatca atacgttatt tttgatgtag ccttacgaaa tatcctacat   180
ggaaatagta atctgtttta cacctttaca agtggtctag ggctaaactt ctatgcccta   240
tctagttatt acttgggtag ttttctcgcg cctctggttt acttttttga tctaacgaat   300
atgccagatg ctatctatct gacaactctc ttaaaatttg gattgattgg tctgtcaacc   360
ttttttagtt tgaataaatt gtttcaatct atccctcaga ttttaaaact agccttatct   420
acttcctatg ctctgatgag tttcactgtc agtcaattag agataaaaac ctggctagat   480
gtttttatct tgattccttt aattataact ggtttacatc tactgataac tgaaaagaaa   540
ctcctattgt actttacaag tctgtcaatc ttatttattc aaaattatta ttttggatat   600
atgacagtat tgtttcttat tttctggtat ctctgtcaaa tttcgtggga ctttaagact   660
cgaaaatcat ctgttcttga tttcatagtt atctcctttt tagctggtat ggctagtttg   720
attatgactc ttcccactct atttgattta cagacacatg gggaaaaatt gactgaagtt   780
acaaagtttc aaactgaaag tagctggtat cttgatctct ttgctaagca attcattggt   840
tcctttgaca caacaaagta tggggccatc ccaatgattt ttgttggact atttcccttt   900
attttgacca ttttattttt tacgctgaaa tctattaagt ttcacgtgaa actcatatat   960
gtaatattct ttgcatttct aattgcaagc ttttacatag aagctcttga cttattttgg   1020
caaggcatgc atactccaaa catgttttta catcgctatg cttggatttt ctctaccttg   1080
ttaatttaca cagcagcaga agtcttaaag cgtctgaaag aacttaaagt ctggaatttt   1140
ttagtttcgc tttttcttgt agtagcagga tttttagcta ccatctatct aaaatcgcat   1200
tattcttttt taacagattt gaatattctg cttactcttg aatttttggt tgtctattct   1260
cttttactcc ttgcagttat caaaaagttt atatctgtga atctatttgc cattctaatc   1320
tctttattta tactggttga aatgagttta aatgcttcat ctcaaatgga cggaattgct   1380
aaggaatggg gatttgcttc tcgaagtgct tatagtcgag atatcccagc tatggaatct   1440
ttctcaacat atattggaaa tcaatttact cgtactgaaa aactacaaac tcagacagga   1500
aatgacagta tgaaattcaa ctacaatgga atctctcaat tttcatctgt tcgaaatcgt   1560
tcatcaagct ctactttaga taaacttggt tttaaatcct ctgggactaa tctcaatctc   1620
cgatatgcaa ataatagtat tttggctgat agtttatttg gtatccagta caatatctca   1680
gacagtccta ttgataagta tggctttaaa gatatctatc aaaaagataa tcttacccta   1740
tatgaaaatc aatactctct tccgattgca gttgcgagtc aatctgttta caatgatgtc   1800
aagttcaatg aacatacctt ggataatcag gcctcatttt taaatcaact tgctaacgtc   1860
aattttgatt atttttctcc aataccttat gaaaaaacag aaaaaataga aaatactaat   1920
gatttgatta gtgtcacaag ttcttcaaat gaagatgcag caatccagta tcaaattgaa   1980
gttccagaaa acagccaagt ttatctctct ttcataaacc ttcacttttc taacgataaa   2040

caaaagaagg ttgacatcct tgtaaatggt gaaaaaaaga cttttacaac tgataatgtc   2100
ttctccttct ttaatctagg atatactaaa gagaaaaaaa ctttcaatat caatgttagt   2160
ttccctggaa attcacaagt atcatttgaa tctcctacct tctatcgttt agataccaaa   2220
actttcaccg aggcaattca aaaaattaaa gaacaacctg tcacagtatc aacttctaaa   2280
aacaaggttt ttgctacata tgatgtccaa caagatacat ctattttctt caccattcct   2340
tatgacaaag gttggtctgc ctaccaagat ggtaagaaaa tagaaattaa acaagctcaa   2400
actggattta tgaaagttga cattcccaag gggaaaggaa ctattacact ttccttcatt   2460
cccaatggtt ttattactgg agcaatctgt tcctttactt ctctcttact atttggaatc   2520
tataatcaca gacgaaagtc atctaaggca                                    2550

<210>   4682
<211>   850
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904077 (0.E+01)

<400>   4682
Met Lys Ser Phe Leu Lys Thr Tyr Arg Thr Tyr Phe Ile Ser Phe Ile 
1               5                   10                  15      

Ile Pro Val Val Ile Met Ser Gly Val Tyr Leu Ser Gln Ser Ile Tyr 
            20                  25                  30          

Trp Asn Ser Asp Asn Ser Pro Leu Leu Gly Asp Gly Phe His Gln Tyr 
        35                  40                  45              

Val Ile Phe Asp Val Ala Leu Arg Asn Ile Leu His Gly Asn Ser Asn 
    50                  55                  60                  

Leu Phe Tyr Thr Phe Thr Ser Gly Leu Gly Leu Asn Phe Tyr Ala Leu 
65                  70                  75                  80  

Ser Ser Tyr Tyr Leu Gly Ser Phe Leu Ala Pro Leu Val Tyr Phe Phe 
                85                  90                  95      

Asp Leu Thr Asn Met Pro Asp Ala Ile Tyr Leu Thr Thr Leu Leu Lys 
            100                 105                 110         

Phe Gly Leu Ile Gly Leu Ser Thr Phe Phe Ser Leu Asn Lys Leu Phe 
        115                 120                 125             

Gln Ser Ile Pro Gln Ile Leu Lys Leu Ala Leu Ser Thr Ser Tyr Ala 
    130                 135                 140                 

Leu Met Ser Phe Thr Val Ser Gln Leu Glu Ile Lys Thr Trp Leu Asp 
145                 150                 155                 160 

Val Phe Ile Leu Ile Pro Leu Ile Ile Thr Gly Leu His Leu Leu Ile 
                165                 170                 175     

Thr Glu Lys Lys Leu Leu Leu Tyr Phe Thr Ser Leu Ser Ile Leu Phe 
            180                 185                 190         

Ile Gln Asn Tyr Tyr Phe Gly Tyr Met Thr Val Leu Phe Leu Ile Phe 
        195                 200                 205             


Trp Tyr Leu Cys Gln Ile Ser Trp Asp Phe Lys Thr Arg Lys Ser Ser 
    210                 215                 220                 

Val Leu Asp Phe Ile Val Ile Ser Phe Leu Ala Gly Met Ala Ser Leu 
225                 230                 235                 240 

Ile Met Thr Leu Pro Thr Leu Phe Asp Leu Gln Thr His Gly Glu Lys 
                245                 250                 255     

Leu Thr Glu Val Thr Lys Phe Gln Thr Glu Ser Ser Trp Tyr Leu Asp 
            260                 265                 270         

Leu Phe Ala Lys Gln Phe Ile Gly Ser Phe Asp Thr Thr Lys Tyr Gly 
        275                 280                 285             

Ala Ile Pro Met Ile Phe Val Gly Leu Phe Pro Phe Ile Leu Thr Ile 
    290                 295                 300                 

Leu Phe Phe Thr Leu Lys Ser Ile Lys Phe His Val Lys Leu Ile Tyr 
305                 310                 315                 320 

Val Ile Phe Phe Ala Phe Leu Ile Ala Ser Phe Tyr Ile Glu Ala Leu 
                325                 330                 335     

Asp Leu Phe Trp Gln Gly Met His Thr Pro Asn Met Phe Leu His Arg 
            340                 345                 350         

Tyr Ala Trp Ile Phe Ser Thr Leu Leu Ile Tyr Thr Ala Ala Glu Val 
        355                 360                 365             

Leu Lys Arg Leu Lys Glu Leu Lys Val Trp Asn Phe Leu Val Ser Leu 
    370                 375                 380                 

Phe Leu Val Val Ala Gly Phe Leu Ala Thr Ile Tyr Leu Lys Ser His 
385                 390                 395                 400 

Tyr Ser Phe Leu Thr Asp Leu Asn Ile Leu Leu Thr Leu Glu Phe Leu 
                405                 410                 415     

Val Val Tyr Ser Leu Leu Leu Leu Ala Val Ile Lys Lys Phe Ile Ser 
            420                 425                 430         

Val Asn Leu Phe Ala Ile Leu Ile Ser Leu Phe Ile Leu Val Glu Met 
        435                 440                 445             

Ser Leu Asn Ala Ser Ser Gln Met Asp Gly Ile Ala Lys Glu Trp Gly 
    450                 455                 460                 

Phe Ala Ser Arg Ser Ala Tyr Ser Arg Asp Ile Pro Ala Met Glu Ser 
465                 470                 475                 480 

Phe Ser Thr Tyr Ile Gly Asn Gln Phe Thr Arg Thr Glu Lys Leu Gln 
                485                 490                 495     

Thr Gln Thr Gly Asn Asp Ser Met Lys Phe Asn Tyr Asn Gly Ile Ser 
            500                 505                 510         

Gln Phe Ser Ser Val Arg Asn Arg Ser Ser Ser Ser Thr Leu Asp Lys 
        515                 520                 525             

Leu Gly Phe Lys Ser Ser Gly Thr Asn Leu Asn Leu Arg Tyr Ala Asn 
    530                 535                 540                 


Asn Ser Ile Leu Ala Asp Ser Leu Phe Gly Ile Gln Tyr Asn Ile Ser 
545                 550                 555                 560 

Asp Ser Pro Ile Asp Lys Tyr Gly Phe Lys Asp Ile Tyr Gln Lys Asp 
                565                 570                 575     

Asn Leu Thr Leu Tyr Glu Asn Gln Tyr Ser Leu Pro Ile Ala Val Ala 
            580                 585                 590         

Ser Gln Ser Val Tyr Asn Asp Val Lys Phe Asn Glu His Thr Leu Asp 
        595                 600                 605             

Asn Gln Ala Ser Phe Leu Asn Gln Leu Ala Asn Val Asn Phe Asp Tyr 
    610                 615                 620                 

Phe Ser Pro Ile Pro Tyr Glu Lys Thr Glu Lys Ile Glu Asn Thr Asn 
625                 630                 635                 640 

Asp Leu Ile Ser Val Thr Ser Ser Ser Asn Glu Asp Ala Ala Ile Gln 
                645                 650                 655     

Tyr Gln Ile Glu Val Pro Glu Asn Ser Gln Val Tyr Leu Ser Phe Ile 
            660                 665                 670         

Asn Leu His Phe Ser Asn Asp Lys Gln Lys Lys Val Asp Ile Leu Val 
        675                 680                 685             

Asn Gly Glu Lys Lys Thr Phe Thr Thr Asp Asn Val Phe Ser Phe Phe 
    690                 695                 700                 

Asn Leu Gly Tyr Thr Lys Glu Lys Lys Thr Phe Asn Ile Asn Val Ser 
705                 710                 715                 720 

Phe Pro Gly Asn Ser Gln Val Ser Phe Glu Ser Pro Thr Phe Tyr Arg 
                725                 730                 735     

Leu Asp Thr Lys Thr Phe Thr Glu Ala Ile Gln Lys Ile Lys Glu Gln 
            740                 745                 750         

Pro Val Thr Val Ser Thr Ser Lys Asn Lys Val Phe Ala Thr Tyr Asp 
        755                 760                 765             

Val Gln Gln Asp Thr Ser Ile Phe Phe Thr Ile Pro Tyr Asp Lys Gly 
    770                 775                 780                 

Trp Ser Ala Tyr Gln Asp Gly Lys Lys Ile Glu Ile Lys Gln Ala Gln 
785                 790                 795                 800 

Thr Gly Phe Met Lys Val Asp Ile Pro Lys Gly Lys Gly Thr Ile Thr 
                805                 810                 815     

Leu Ser Phe Ile Pro Asn Gly Phe Ile Thr Gly Ala Ile Cys Ser Phe 
            820                 825                 830         

Thr Ser Leu Leu Leu Phe Gly Ile Tyr Asn His Arg Arg Lys Ser Ser 
        835                 840                 845             

Lys Ala 
    850 

<210>   4683
<211>   677
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4683
ttggcagatg gatctgggaa actagcagaa ggtggaacaa agttaacttc tggattggaa   60
gatttacaga caggacttgc ttctttagga caaggactag gtaatgctag tgatcaactc   120
aaatcagtat caacagaatc taaaaatgca gagattttgt caaatccact caatctttca   180
aaaacagaca atgatcaagt tcctgtaaat ggaatcgcaa tagctcctta tatgatatca   240
gttgctcttt ttttgcagca atatcaacaa atatgatatt tgcgaaattg ccttcaggac   300
gtcatccaga gagccgttgg gcttggttga aatcttgagc tgaaataaat ggtattatag   360
ctgttttggc aggaattttg gtatatggag gagttcagct tattggttta actgctaatc   420
atgagatgag aatatttatt ctcatcatcc taacaagttt agtattcatg tctatggtga   480
ccactttagc aacgtggaat agccgtatag gagctttttt ctcacttatt ttgcttttac   540
tacagttagc atcaagtgca ggtacttatc cacttgcttt gacaaatgat ttctttagat   600
ctattaatcc ctggttacca atgagctatt cagtttcggg attacgacaa acaatctcta   660
tcaacaagtc attttcc                                                  677


<210>   4684
<400>   4684
000

<210>   4685
<211>   765
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4685
atgatcggga tttctcttat tccagatctg tacaatatca tatttttgtc atcaatgtgg   60
gatccatatg ggcaattgtc tgacttacct gtggcagttg taaataatga taaagaggct   120
tcctataatg gtaatactat ggcaatagga aaagacatgg tgtccaattt aaaagaaaat   180
aaaaccttgg attttcattt tgtagatgaa gaggaaggaa agaagggatt ggaagatggc   240
gattactata tggtagtgac tttaccaagt gatttatctg aaaaaacaac tacattatcc   300
aatattcaat cgacagcagc ttatcaatca ttgacaagtg agcaacaaac tgagataagt   360
gattctgtat ctcaaaattc aactgatagt attcaatcgg ctcagtcaat tgtagcttta   420
gtacaagatt tacagggaag tttagaaaac ttacaaaatc aatcttctaa tctttcgact   480
ttaaaaaatc aatctaatca agtatcacct attacttcta cttctttgat aggattgtca   540
agtggattaa cagagataca aggagatgtt actagcaaat tagttcctgc cagtcagtcg   600
attgcatcag gtgtaaacgc atatactaca ggtgttgata aagtttctca gggcgcaagt   660
caactaagtg aaaaaaatgc caccttgaca ggtagtttgg ataaactagt ttcaggctca   720
aacaccttga cacaaaaatc ttctagattg acagcaggag ttggt                   765

<210>   4686
<211>   255
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Feature of note: similar to toxin Deinococcus
<223>   Similar to strain R6 sequence 15904080 (e-139)

<400>   4686
Met Ile Gly Ile Ser Leu Ile Pro Asp Leu Tyr Asn Ile Ile Phe Leu 
1               5                   10                  15      

Ser Ser Met Trp Asp Pro Tyr Gly Gln Leu Ser Asp Leu Pro Val Ala 
            20                  25                  30          

Val Val Asn Asn Asp Lys Glu Ala Ser Tyr Asn Gly Asn Thr Met Ala 
        35                  40                  45              

Ile Gly Lys Asp Met Val Ser Asn Leu Lys Glu Asn Lys Thr Leu Asp 
    50                  55                  60                  

Phe His Phe Val Asp Glu Glu Glu Gly Lys Lys Gly Leu Glu Asp Gly 
65                  70                  75                  80  

Asp Tyr Tyr Met Val Val Thr Leu Pro Ser Asp Leu Ser Glu Lys Thr 
                85                  90                  95      

Thr Thr Leu Ser Asn Ile Gln Ser Thr Ala Ala Tyr Gln Ser Leu Thr 
            100                 105                 110         

Ser Glu Gln Gln Thr Glu Ile Ser Asp Ser Val Ser Gln Asn Ser Thr 
        115                 120                 125             

Asp Ser Ile Gln Ser Ala Gln Ser Ile Val Ala Leu Val Gln Asp Leu 
    130                 135                 140                 

Gln Gly Ser Leu Glu Asn Leu Gln Asn Gln Ser Ser Asn Leu Ser Thr 
145                 150                 155                 160 

Leu Lys Asn Gln Ser Asn Gln Val Ser Pro Ile Thr Ser Thr Ser Leu 
                165                 170                 175     

Ile Gly Leu Ser Ser Gly Leu Thr Glu Ile Gln Gly Asp Val Thr Ser 
            180                 185                 190         

Lys Leu Val Pro Ala Ser Gln Ser Ile Ala Ser Gly Val Asn Ala Tyr 
        195                 200                 205             

Thr Thr Gly Val Asp Lys Val Ser Gln Gly Ala Ser Gln Leu Ser Glu 
    210                 215                 220                 

Lys Asn Ala Thr Leu Thr Gly Ser Leu Asp Lys Leu Val Ser Gly Ser 
225                 230                 235                 240 

Asn Thr Leu Thr Gln Lys Ser Ser Arg Leu Thr Ala Gly Val Gly 
                245                 250                 255 

<210>   4687
<211>   540
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4687
atgcaagaaa gtaacaaacg cttaaaaaca aagcgaacta ttgaaaatgc tatggtacaa   60
ttactgatgg aacagccatt tgataaaatt tctactgtca aattagtaga aaaagccgga   120
attagtcgtt ccagcttcta tactcactat aaggataagt atgatatgat tgagcactat   180
caaagcaagc tattccatac atttgaatat atttttcaaa aacatgctca tcacaaaaga   240
gacgctattt tagaagtttt tgaatatcta gagtcagaac cacttctggc tgcccttctt   300
tctgaaaatg ggactaaaga aatccaaaat ttcttacgaa ataaacttca tatcatgctt   360
agtacagatt tacaaaagcg atttatgcaa ctgaatctaa ataccactga attagaatat   420
agtagcatct atctaactca tgcacttttt ggtgtctgcc aaacttggat tgcacatgga   480
aaaaaagaaa gttctcaaga aataacagac ttccttatga aaatgcttgg tgatacaaat   540

<210>   4688
<211>   180
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, TetR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904081 (e-102)

<400>   4688
Met Gln Glu Ser Asn Lys Arg Leu Lys Thr Lys Arg Thr Ile Glu Asn 
1               5                   10                  15      

Ala Met Val Gln Leu Leu Met Glu Gln Pro Phe Asp Lys Ile Ser Thr 
            20                  25                  30          

Val Lys Leu Val Glu Lys Ala Gly Ile Ser Arg Ser Ser Phe Tyr Thr 
        35                  40                  45              

His Tyr Lys Asp Lys Tyr Asp Met Ile Glu His Tyr Gln Ser Lys Leu 
    50                  55                  60                  

Phe His Thr Phe Glu Tyr Ile Phe Gln Lys His Ala His His Lys Arg 
65                  70                  75                  80  

Asp Ala Ile Leu Glu Val Phe Glu Tyr Leu Glu Ser Glu Pro Leu Leu 
                85                  90                  95      

Ala Ala Leu Leu Ser Glu Asn Gly Thr Lys Glu Ile Gln Asn Phe Leu 
            100                 105                 110         

Arg Asn Lys Leu His Ile Met Leu Ser Thr Asp Leu Gln Lys Arg Phe 
        115                 120                 125             

Met Gln Leu Asn Leu Asn Thr Thr Glu Leu Glu Tyr Ser Ser Ile Tyr 
    130                 135                 140                 

Leu Thr His Ala Leu Phe Gly Val Cys Gln Thr Trp Ile Ala His Gly 
145                 150                 155                 160 

Lys Lys Glu Ser Ser Gln Glu Ile Thr Asp Phe Leu Met Lys Met Leu 
                165                 170                 175     

Gly Asp Thr Asn 
            180 

<210>   4689
<211>   750
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4689
atgaaagttt taattttaga agatgttatt gaacatcaag tgagactaga gagaatattg   60
gatgaaattt cgaaagaatc gaatattcca atatcataca agacaacggg aaaagtccgt   120
gaatttgaag aatacattga aaatgatgaa gtaaatcagc tttatttcct agatatcgat   180
attcatggaa ttgagaaaaa gggatttgaa gtggctcagc tcattcgtca ttacaatcct   240
tacgctatta tcgtctttat cactagtcga tcagagtttg cgactctaac ctataaatac   300
caggtatcag ccctagattt tgttgataag gatatcaatg atgagatgtt taagaagaga   360
attgagcaaa atatcttcta cacgaagagt atgttacttg aaaatgaaga tgttgtagat   420
tatttcgact acaattacaa gggaaatgat ttaaaaattc cttaccatga tattttgtat   480
attgaaacaa caggggtatc tcataaattg cgcattattg gtaagaattt tgcaaaagag   540
ttttatggta ccatgacaga tattcaggaa aaggacaaac atactcagcg attttattct   600
cctcacaagt catttttggt aaatataggt aatatcagag aaattgatcg aaaaaactta   660
gaaattgttt tctatgaaga ccatcgttgt cctatttcaa gattaaaaat tagaaaatta   720
aaagatattt tagagaaaaa atctcaaaag                                    750

<210>   4690
<211>   250
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   response regulator ComE (comE)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904082 (e-144)

<400>   4690
Met Lys Val Leu Ile Leu Glu Asp Val Ile Glu His Gln Val Arg Leu 
1               5                   10                  15      

Glu Arg Ile Leu Asp Glu Ile Ser Lys Glu Ser Asn Ile Pro Ile Ser 
            20                  25                  30          

Tyr Lys Thr Thr Gly Lys Val Arg Glu Phe Glu Glu Tyr Ile Glu Asn 
        35                  40                  45              

Asp Glu Val Asn Gln Leu Tyr Phe Leu Asp Ile Asp Ile His Gly Ile 
    50                  55                  60                  

Glu Lys Lys Gly Phe Glu Val Ala Gln Leu Ile Arg His Tyr Asn Pro 
65                  70                  75                  80  

Tyr Ala Ile Ile Val Phe Ile Thr Ser Arg Ser Glu Phe Ala Thr Leu 
                85                  90                  95      

Thr Tyr Lys Tyr Gln Val Ser Ala Leu Asp Phe Val Asp Lys Asp Ile 
            100                 105                 110         

Asn Asp Glu Met Phe Lys Lys Arg Ile Glu Gln Asn Ile Phe Tyr Thr 
        115                 120                 125             

Lys Ser Met Leu Leu Glu Asn Glu Asp Val Val Asp Tyr Phe Asp Tyr 
    130                 135                 140                 

Asn Tyr Lys Gly Asn Asp Leu Lys Ile Pro Tyr His Asp Ile Leu Tyr 
145                 150                 155                 160 

Ile Glu Thr Thr Gly Val Ser His Lys Leu Arg Ile Ile Gly Lys Asn 
                165                 170                 175     

Phe Ala Lys Glu Phe Tyr Gly Thr Met Thr Asp Ile Gln Glu Lys Asp 
            180                 185                 190         

Lys His Thr Gln Arg Phe Tyr Ser Pro His Lys Ser Phe Leu Val Asn 
        195                 200                 205             

Ile Gly Asn Ile Arg Glu Ile Asp Arg Lys Asn Leu Glu Ile Val Phe 
    210                 215                 220                 

Tyr Glu Asp His Arg Cys Pro Ile Ser Arg Leu Lys Ile Arg Lys Leu 
225                 230                 235                 240 

Lys Asp Ile Leu Glu Lys Lys Ser Gln Lys 
                245                 250 

<210>   4691
<211>   1323
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4691
atggatttac ttggatttgg gacagttatt gttcattttt taattattag tcacagttac   60
cgtttaattt gtaaaggtcg aataaataga aaagaattat acgtttttgg tgcttataca   120
ttactaactg aaatagtact tgaattttcc ttttatcttc tatatttaga taaaataggg   180
attgaaagat ttttatttcc tttgggctta tattcctatt ttcgatggat gaaacagtat   240
gagagggata gaggactatt cctaagttta ctactatctc ttttatatga gagcactcat   300
aactttctgt ccgtaatttt ctcctctata acaggagata attttgtttt acaatatcat   360
ttcccattct ttttcgttgt gacggtgtta acctattttg ttacattaaa aatcatttac   420
tatttccatt tggaactagc ctattttgac aaggactacc tttatccttt cttgaaaaaa   480
gtattttttg ctttactatt gctacatatt gtatctttcg tttcagatat ggtaagtacg   540
attaaacatt tgaatagttt tggaagtatt ttgtcatcta ttgtctttat ctctctcctt   600
ttgaccttct ttgcaatgaa ttctcataaa gttcaaatgg agaaagagat tgctttgaag   660
cagaagaaat ttgaacagaa acatttacag aattacacag atgaaattgt tggtctgtat   720
aatgaaatcc gtggttttcg acatgattat gctggaatgc ttgtcagcat gcagatggca   780
attgacagtg gtaatttaca ggaaattgac agaatttaca atgaagtttt agtcaaagca   840
aatcataaat tgcgttcaga taagtacact tactttgatt tgaacaacat agaagactca   900
gctttacgaa gtttggttgc tcagtcaatt gtctatgctc gaaataatgg tgtagagttt   960
acactggaag taaaagatac gattaccaag cttccaattg aactattgga tttggttcgt   1020
atcatgagcg ttttattgaa taatgctgtc gaaggatcgg ctgatagcta taaaaagcag   1080
atggaagtag cagttattaa gatggaaact gaaacagtta ttgtgattca gaattcatgt   1140
aaaatgacga tgactccttc aggagatcta tttgccttag gattctccac taagggaaga   1200
aatcgcggag tcggattaaa taatgtgaaa gaactactag ataagtacaa caatattatt   1260
ttagaaacag agatggaagg cagtacattt agacaaatca ttagatttaa gagggaattt   1320
gaa                                                                 1323

<210>   4692
<211>   441
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   putative sensor histidine kinase ComD (comD)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904083 (0.E+01)

<400>   4692
Met Asp Leu Leu Gly Phe Gly Thr Val Ile Val His Phe Leu Ile Ile 
1               5                   10                  15      

Ser His Ser Tyr Arg Leu Ile Cys Lys Gly Arg Ile Asn Arg Lys Glu 
            20                  25                  30          

Leu Tyr Val Phe Gly Ala Tyr Thr Leu Leu Thr Glu Ile Val Leu Glu 
        35                  40                  45              

Phe Ser Phe Tyr Leu Leu Tyr Leu Asp Lys Ile Gly Ile Glu Arg Phe 
    50                  55                  60                  

Leu Phe Pro Leu Gly Leu Tyr Ser Tyr Phe Arg Trp Met Lys Gln Tyr 
65                  70                  75                  80  

Glu Arg Asp Arg Gly Leu Phe Leu Ser Leu Leu Leu Ser Leu Leu Tyr 
                85                  90                  95      

Glu Ser Thr His Asn Phe Leu Ser Val Ile Phe Ser Ser Ile Thr Gly 
            100                 105                 110         

Asp Asn Phe Val Leu Gln Tyr His Phe Pro Phe Phe Phe Val Val Thr 
        115                 120                 125             

Val Leu Thr Tyr Phe Val Thr Leu Lys Ile Ile Tyr Tyr Phe His Leu 
    130                 135                 140                 

Glu Leu Ala Tyr Phe Asp Lys Asp Tyr Leu Tyr Pro Phe Leu Lys Lys 
145                 150                 155                 160 

Val Phe Phe Ala Leu Leu Leu Leu His Ile Val Ser Phe Val Ser Asp 
                165                 170                 175     

Met Val Ser Thr Ile Lys His Leu Asn Ser Phe Gly Ser Ile Leu Ser 
            180                 185                 190         

Ser Ile Val Phe Ile Ser Leu Leu Leu Thr Phe Phe Ala Met Asn Ser 
        195                 200                 205             

His Lys Val Gln Met Glu Lys Glu Ile Ala Leu Lys Gln Lys Lys Phe 
    210                 215                 220                 

Glu Gln Lys His Leu Gln Asn Tyr Thr Asp Glu Ile Val Gly Leu Tyr 
225                 230                 235                 240 

Asn Glu Ile Arg Gly Phe Arg His Asp Tyr Ala Gly Met Leu Val Ser 
                245                 250                 255     

Met Gln Met Ala Ile Asp Ser Gly Asn Leu Gln Glu Ile Asp Arg Ile 
            260                 265                 270         

Tyr Asn Glu Val Leu Val Lys Ala Asn His Lys Leu Arg Ser Asp Lys 
        275                 280                 285             

Tyr Thr Tyr Phe Asp Leu Asn Asn Ile Glu Asp Ser Ala Leu Arg Ser 
    290                 295                 300                 

Leu Val Ala Gln Ser Ile Val Tyr Ala Arg Asn Asn Gly Val Glu Phe 
305                 310                 315                 320 

Thr Leu Glu Val Lys Asp Thr Ile Thr Lys Leu Pro Ile Glu Leu Leu 
                325                 330                 335     

Asp Leu Val Arg Ile Met Ser Val Leu Leu Asn Asn Ala Val Glu Gly 
            340                 345                 350         

Ser Ala Asp Ser Tyr Lys Lys Gln Met Glu Val Ala Val Ile Lys Met 
        355                 360                 365             

Glu Thr Glu Thr Val Ile Val Ile Gln Asn Ser Cys Lys Met Thr Met 
    370                 375                 380                 

Thr Pro Ser Gly Asp Leu Phe Ala Leu Gly Phe Ser Thr Lys Gly Arg 
385                 390                 395                 400 

Asn Arg Gly Val Gly Leu Asn Asn Val Lys Glu Leu Leu Asp Lys Tyr 
                405                 410                 415     

Asn Asn Ile Ile Leu Glu Thr Glu Met Glu Gly Ser Thr Phe Arg Gln 
            420                 425                 430         

Ile Ile Arg Phe Lys Arg Glu Phe Glu 
        435                 440     

<210>   4693
<211>   123
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4693
atgaaaaaca cagttaaatt ggaacagttt gtagctttga aggaaaaaga cttacaaaag   60
attaaaggtg gggagatgag gatttcaaga atcatccttg attttctttt cctacgaaaa   120
aag                                                                 123

<210>   4694
<211>   41
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence stimulating peptide 2 (comC2)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904084 (3.E-14)

<400>   4694
Met Lys Asn Thr Val Lys Leu Glu Gln Phe Val Ala Leu Lys Glu Lys 
1               5                   10                  15      

Asp Leu Gln Lys Ile Lys Gly Gly Glu Met Arg Ile Ser Arg Ile Ile 
            20                  25                  30          

Leu Asp Phe Leu Phe Leu Arg Lys Lys 
        35                  40      

<210>   4695
<211>   477
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4695
atgaaaatta aagttgtaac agttgggaaa ctgaaagaaa agtatttaaa agatggtatc   60
gcagagtatt caaaacgaat ttctagattt gctaagtttg aaatgattga gttatcagat   120
gaaaaaacac cagataaggc cagtgaatca gaaaatcaaa agattttaga aatagaaggt   180
cagagaattt tatcaaaaat tgctgaccgt gatttcgtta ttgtgttagc cattgaaggg   240
aaaactttct tctcagaaga atttagtaag cagttagaag aaacttctat aaaaggattt   300
tctactctta cttttattat tgggggaagt ttaggattat catcatctgt aaaaaataga   360
gccaatcttt ctgtcagttt tggtcgccta accttacccc atcagttaat gagactagtt   420
cttgttgaac aaatctatcg cgcttttacg attcagcagg gattccccta ccataaa      477

<210>   4696
<211>   159
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904085 (7.E-85)

<400>   4696
Met Lys Ile Lys Val Val Thr Val Gly Lys Leu Lys Glu Lys Tyr Leu 
1               5                   10                  15      

Lys Asp Gly Ile Ala Glu Tyr Ser Lys Arg Ile Ser Arg Phe Ala Lys 
            20                  25                  30          

Phe Glu Met Ile Glu Leu Ser Asp Glu Lys Thr Pro Asp Lys Ala Ser 
        35                  40                  45              

Glu Ser Glu Asn Gln Lys Ile Leu Glu Ile Glu Gly Gln Arg Ile Leu 
    50                  55                  60                  

Ser Lys Ile Ala Asp Arg Asp Phe Val Ile Val Leu Ala Ile Glu Gly 
65                  70                  75                  80  

Lys Thr Phe Phe Ser Glu Glu Phe Ser Lys Gln Leu Glu Glu Thr Ser 
                85                  90                  95      

Ile Lys Gly Phe Ser Thr Leu Thr Phe Ile Ile Gly Gly Ser Leu Gly 
            100                 105                 110         

Leu Ser Ser Ser Val Lys Asn Arg Ala Asn Leu Ser Val Ser Phe Gly 
        115                 120                 125             

Arg Leu Thr Leu Pro His Gln Leu Met Arg Leu Val Leu Val Glu Gln 
    130                 135                 140                 

Ile Tyr Arg Ala Phe Thr Ile Gln Gln Gly Phe Pro Tyr His Lys 
145                 150                 155                 

<210>   4697
<211>   1191
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4697
atggaggcaa atatgaaaca tctaaaaaca ttttacaaaa aatggtttca attattagtc   60
gttatcgtca ttagcttttt tagtggagcc ttgggtagtt tttcaataac tcaactaact   120
caaaaaagta gtgtaaacaa ctctaacaac aatagtacta ttacacaaac tgcctataag   180

aacgaaaatt caacaacaca ggctgttaac aaagtaaaag atgctgttgt ttctgttatt   240
acttattcgg caaacagaca aaatagcgta tttggcaatg atgatactga cacagattct   300
cagcgaatct ctagtgaagg atctggagtt atttataaaa agaatgataa agaagcttac   360
atcgtcacca acaatcacgt tattaatggc gccagcaaag tagatattcg attgtcagat   420
gggactaaag tacctggaga aattgtcgga gctgacactt tctctgatat tgctgtcgtc   480
aaaatctctt cagaaaaagt gacaacagta gctgagtttg gtgattctag taagttaact   540
gtaggagaaa ctgctattgc catcggtagc ccgttaggtt ctgaatatgc aaatactgtc   600
actcaaggta tcgtatccag tctcaataga aatgtatcct taaaatcgga agatggacaa   660
gctatttcta caaaagccat ccaaactgat actgctatta acccaggtaa ctctggcggc   720
ccactgatca atattcaagg gcaggttatc ggaattacct caagtaaaat tgctacaaat   780
ggaggaacat ctgtagaagg tcttggtttc gcaattcctg caaatgatgc tatcaatatt   840
attgaacagt tagaaaaaaa cggaaaagtg acgcgtccag ctttgggaat ccagatggtt   900
aatttatcta atgtgagtac aagcgacatc agaagactca atattccaag taatgttaca   960
tctggtgtaa ttgttcgttc ggtacaaagt aatatgcctg ccaatggtca ccttgaaaaa   1020
tacgatgtaa ttacaaaagt agatgacaaa gagattgctt catcaacaga cttacaaagt   1080
gctctttaca accattctat cggagacacc attaagataa cctactatcg taacgggaaa   1140
gaagaaacta cctctatcaa acttaacaag agttcaggtg atttagaatc t            1191

<210>   4698
<211>   397
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   serine protease
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15904086 (0.E+01)

<400>   4698
Met Glu Ala Asn Met Lys His Leu Lys Thr Phe Tyr Lys Lys Trp Phe 
1               5                   10                  15      

Gln Leu Leu Val Val Ile Val Ile Ser Phe Phe Ser Gly Ala Leu Gly 
            20                  25                  30          

Ser Phe Ser Ile Thr Gln Leu Thr Gln Lys Ser Ser Val Asn Asn Ser 
        35                  40                  45              

Asn Asn Asn Ser Thr Ile Thr Gln Thr Ala Tyr Lys Asn Glu Asn Ser 
    50                  55                  60                  

Thr Thr Gln Ala Val Asn Lys Val Lys Asp Ala Val Val Ser Val Ile 
65                  70                  75                  80  

Thr Tyr Ser Ala Asn Arg Gln Asn Ser Val Phe Gly Asn Asp Asp Thr 
                85                  90                  95      

Asp Thr Asp Ser Gln Arg Ile Ser Ser Glu Gly Ser Gly Val Ile Tyr 
            100                 105                 110         

Lys Lys Asn Asp Lys Glu Ala Tyr Ile Val Thr Asn Asn His Val Ile 
        115                 120                 125             

Asn Gly Ala Ser Lys Val Asp Ile Arg Leu Ser Asp Gly Thr Lys Val 
    130                 135                 140                 

Pro Gly Glu Ile Val Gly Ala Asp Thr Phe Ser Asp Ile Ala Val Val 
145                 150                 155                 160 

Lys Ile Ser Ser Glu Lys Val Thr Thr Val Ala Glu Phe Gly Asp Ser 
                165                 170                 175     

Ser Lys Leu Thr Val Gly Glu Thr Ala Ile Ala Ile Gly Ser Pro Leu 
            180                 185                 190         

Gly Ser Glu Tyr Ala Asn Thr Val Thr Gln Gly Ile Val Ser Ser Leu 
        195                 200                 205             

Asn Arg Asn Val Ser Leu Lys Ser Glu Asp Gly Gln Ala Ile Ser Thr 
    210                 215                 220                 

Lys Ala Ile Gln Thr Asp Thr Ala Ile Asn Pro Gly Asn Ser Gly Gly 
225                 230                 235                 240 

Pro Leu Ile Asn Ile Gln Gly Gln Val Ile Gly Ile Thr Ser Ser Lys 
                245                 250                 255     

Ile Ala Thr Asn Gly Gly Thr Ser Val Glu Gly Leu Gly Phe Ala Ile 
            260                 265                 270         

Pro Ala Asn Asp Ala Ile Asn Ile Ile Glu Gln Leu Glu Lys Asn Gly 
        275                 280                 285             

Lys Val Thr Arg Pro Ala Leu Gly Ile Gln Met Val Asn Leu Ser Asn 
    290                 295                 300                 

Val Ser Thr Ser Asp Ile Arg Arg Leu Asn Ile Pro Ser Asn Val Thr 
305                 310                 315                 320 

Ser Gly Val Ile Val Arg Ser Val Gln Ser Asn Met Pro Ala Asn Gly 
                325                 330                 335     

His Leu Glu Lys Tyr Asp Val Ile Thr Lys Val Asp Asp Lys Glu Ile 
            340                 345                 350         

Ala Ser Ser Thr Asp Leu Gln Ser Ala Leu Tyr Asn His Ser Ile Gly 
        355                 360                 365             

Asp Thr Ile Lys Ile Thr Tyr Tyr Arg Asn Gly Lys Glu Glu Thr Thr 
    370                 375                 380                 

Ser Ile Lys Leu Asn Lys Ser Ser Gly Asp Leu Glu Ser 
385                 390                 395         

<210>   4699
<211>   756
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4699
atggaaaaat ttgaaatgat ttctatcaca gatatacaaa aaaatcccta tcaaccccga   60
aaagaatttg atagagaaaa actagatgaa ctagcacagt ctatcaaaga aaatggggtc   120
attcaaccga ttattgttcg tcaatctcct gttattggtt atgaaatcct tgcaggagag   180
agacgctatc gggcttcact tttagctggt ctacggtcta tcccagctgt tgttaaacag   240
atttcagacc aagagatgat ggtccagtcc attattgaaa atttacagag agaaaattta   300
aacccaatag aagaagcacg cgcctatgaa tctctcgtag agaaaggatt cacccatgct   360
gaaattgcag ataagatggg caagtctcgt ccatatatca gcaactccat tcgtttactt   420
tccttgccag aacagattct ttcagaagta gaaaatggca aactatcaca agcccatgcg   480
cgttccctag ttgggttaaa taaggaacaa caagactatt tctttcaacg gattatagaa   540
gaagatattt ctgtaaggaa attagaagct cttctgacag agaaaaaaca aaagaaacag   600
caaaaaacta atcatttcat acaaaatgaa gaaaaacagt taagaaaact actcggatta   660
gatgtagaaa ttaaactatc taaaaaagac agtggaaaaa tcattatttc tttttcaaat   720
caagaagaat atagtagaat tatcaacagc ctgaaa                             756

<210>   4700
<211>   252
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   spspoJ protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15904087 (e-138)

<400>   4700
Met Glu Lys Phe Glu Met Ile Ser Ile Thr Asp Ile Gln Lys Asn Pro 
1               5                   10                  15      

Tyr Gln Pro Arg Lys Glu Phe Asp Arg Glu Lys Leu Asp Glu Leu Ala 
            20                  25                  30          

Gln Ser Ile Lys Glu Asn Gly Val Ile Gln Pro Ile Ile Val Arg Gln 
        35                  40                  45              

Ser Pro Val Ile Gly Tyr Glu Ile Leu Ala Gly Glu Arg Arg Tyr Arg 
    50                  55                  60                  

Ala Ser Leu Leu Ala Gly Leu Arg Ser Ile Pro Ala Val Val Lys Gln 
65                  70                  75                  80  

Ile Ser Asp Gln Glu Met Met Val Gln Ser Ile Ile Glu Asn Leu Gln 
                85                  90                  95      

Arg Glu Asn Leu Asn Pro Ile Glu Glu Ala Arg Ala Tyr Glu Ser Leu 
            100                 105                 110         

Val Glu Lys Gly Phe Thr His Ala Glu Ile Ala Asp Lys Met Gly Lys 
        115                 120                 125             

Ser Arg Pro Tyr Ile Ser Asn Ser Ile Arg Leu Leu Ser Leu Pro Glu 
    130                 135                 140                 

Gln Ile Leu Ser Glu Val Glu Asn Gly Lys Leu Ser Gln Ala His Ala 
145                 150                 155                 160 

Arg Ser Leu Val Gly Leu Asn Lys Glu Gln Gln Asp Tyr Phe Phe Gln 
                165                 170                 175     

Arg Ile Ile Glu Glu Asp Ile Ser Val Arg Lys Leu Glu Ala Leu Leu 
            180                 185                 190         

Thr Glu Lys Lys Gln Lys Lys Gln Gln Lys Thr Asn His Phe Ile Gln 
        195                 200                 205             

Asn Glu Glu Lys Gln Leu Arg Lys Leu Leu Gly Leu Asp Val Glu Ile 
    210                 215                 220                 

Lys Leu Ser Lys Lys Asp Ser Gly Lys Ile Ile Ile Ser Phe Ser Asn 
225                 230                 235                 240 

Gln Glu Glu Tyr Ser Arg Ile Ile Asn Ser Leu Lys 
                245                 250         

<210>   4701
<211>   1359
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4701
ttgaaagaaa aacaattttg gaatcgtata ttagaatttg cacaagaaag actgactcga   60
tccatgtatg atttctatgc tattcaagct gaactcatca aggtagagga aaatgttgcc   120
actatatttc tacctcgctc tgaaatggaa atggtctggg aaaaacaact aaaagatatt   180
attgtagtag ctggttttga aatttatgac gctgaaataa ctccccacta tattttcacc   240
aaacctcaag atacgactag ctcacaagtt gaagaagcta caaatttaac tctttataac   300
tatagtccaa agttagtatc tattccttat tcagatacgg gattaaaaga aaagtatacc   360
tttgataact ttattcaagg ggatggaaat gtttgggctg tatcagccgc tttagctgtc   420
tctgaagatt tggctctgac ctataaccct ctttttatct atggaggacc aggccttggt   480
aagactcact tattaaacgc tattggaaat gaaattctaa aaaatattcc taatgcgcgt   540
gttaaatata tccctgccga aagctttatt aatgactttc ttgatcacct aagacttggg   600
gaaatggaaa agtttaaaaa gacctatcgt agtcttgatc ttttgttaat cgatgatatc   660
cagtcactca gcggaaaaaa agtcgcaact caggaagaat ttttcaatac ctttaacgcc   720
cttcatgaca agcaaaaaca gattgtccta acgagtgatc gtagtccaaa acatctagaa   780
gggctcgagg agaggcttgt cacgcgtttt agttggggat tgacacaaac tatcaccccc   840
cctgactttg aaacacgtat tgccatttta caaagtaaga cggaacattt aggctacaat   900
ttccaaagtg atactctaga atacctagct gggcaatttg attcaaatgt tcgagatctt   960
gagggagcca tcaacgacat cactttaatt gccagagtaa aaaaaatcaa ggatatcact   1020
attgatattg ctgcagaagc cattagagcc cgcaaacaag atgttagcca aatgctcgtc   1080
atcccaattg ataaaatcca aactgaagtt ggtaactttt atggtgttag tatcaaagaa   1140
atgaagggaa gtagacgcct tcaaaatatt gttttggccc gtcaagtagc catgtattta   1200
tctagagaac taacagataa tagtcttcca aaaattggga aggaatttgg gggaaaagat   1260
cataccacag tcattcatgc ccatgccaaa ataaaatctt tgattgatca agacgataat   1320
ttacgtttag aaattgaatc aatcaaaaag aaaatcaaa                          1359

<210>   4702
<211>   453
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   chromosomal replication initiator protein DnaA (dnaA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902045 (0.E+01)

<400>   4702
Met Lys Glu Lys Gln Phe Trp Asn Arg Ile Leu Glu Phe Ala Gln Glu 
1               5                   10                  15      

Arg Leu Thr Arg Ser Met Tyr Asp Phe Tyr Ala Ile Gln Ala Glu Leu 
            20                  25                  30          

Ile Lys Val Glu Glu Asn Val Ala Thr Ile Phe Leu Pro Arg Ser Glu 
        35                  40                  45              

Met Glu Met Val Trp Glu Lys Gln Leu Lys Asp Ile Ile Val Val Ala 
    50                  55                  60                  

Gly Phe Glu Ile Tyr Asp Ala Glu Ile Thr Pro His Tyr Ile Phe Thr 
65                  70                  75                  80  

Lys Pro Gln Asp Thr Thr Ser Ser Gln Val Glu Glu Ala Thr Asn Leu 
                85                  90                  95      

Thr Leu Tyr Asn Tyr Ser Pro Lys Leu Val Ser Ile Pro Tyr Ser Asp 
            100                 105                 110         

Thr Gly Leu Lys Glu Lys Tyr Thr Phe Asp Asn Phe Ile Gln Gly Asp 
        115                 120                 125             

Gly Asn Val Trp Ala Val Ser Ala Ala Leu Ala Val Ser Glu Asp Leu 
    130                 135                 140                 

Ala Leu Thr Tyr Asn Pro Leu Phe Ile Tyr Gly Gly Pro Gly Leu Gly 
145                 150                 155                 160 

Lys Thr His Leu Leu Asn Ala Ile Gly Asn Glu Ile Leu Lys Asn Ile 
                165                 170                 175     

Pro Asn Ala Arg Val Lys Tyr Ile Pro Ala Glu Ser Phe Ile Asn Asp 
            180                 185                 190         


Phe Leu Asp His Leu Arg Leu Gly Glu Met Glu Lys Phe Lys Lys Thr 
        195                 200                 205             

Tyr Arg Ser Leu Asp Leu Leu Leu Ile Asp Asp Ile Gln Ser Leu Ser 
    210                 215                 220                 

Gly Lys Lys Val Ala Thr Gln Glu Glu Phe Phe Asn Thr Phe Asn Ala 
225                 230                 235                 240 

Leu His Asp Lys Gln Lys Gln Ile Val Leu Thr Ser Asp Arg Ser Pro 
                245                 250                 255     

Lys His Leu Glu Gly Leu Glu Glu Arg Leu Val Thr Arg Phe Ser Trp 
            260                 265                 270         

Gly Leu Thr Gln Thr Ile Thr Pro Pro Asp Phe Glu Thr Arg Ile Ala 
        275                 280                 285             

Ile Leu Gln Ser Lys Thr Glu His Leu Gly Tyr Asn Phe Gln Ser Asp 
    290                 295                 300                 

Thr Leu Glu Tyr Leu Ala Gly Gln Phe Asp Ser Asn Val Arg Asp Leu 
305                 310                 315                 320 

Glu Gly Ala Ile Asn Asp Ile Thr Leu Ile Ala Arg Val Lys Lys Ile 
                325                 330                 335     

Lys Asp Ile Thr Ile Asp Ile Ala Ala Glu Ala Ile Arg Ala Arg Lys 
            340                 345                 350         

Gln Asp Val Ser Gln Met Leu Val Ile Pro Ile Asp Lys Ile Gln Thr 
        355                 360                 365             

Glu Val Gly Asn Phe Tyr Gly Val Ser Ile Lys Glu Met Lys Gly Ser 
    370                 375                 380                 

Arg Arg Leu Gln Asn Ile Val Leu Ala Arg Gln Val Ala Met Tyr Leu 
385                 390                 395                 400 

Ser Arg Glu Leu Thr Asp Asn Ser Leu Pro Lys Ile Gly Lys Glu Phe 
                405                 410                 415     

Gly Gly Lys Asp His Thr Thr Val Ile His Ala His Ala Lys Ile Lys 
            420                 425                 430         

Ser Leu Ile Asp Gln Asp Asp Asn Leu Arg Leu Glu Ile Glu Ser Ile 
        435                 440                 445             

Lys Lys Lys Ile Lys 
    450             

<210>   4703
<211>   1134
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4703
atgattcatt tttcaattaa taaaaattta tttctacaag cattaaatac tactaagaga   60
gctattagtt ctaaaaatgc cattcctatt ttatcaacag taaaaattga cgtgaccaat   120
gaaggtatta ctttaattgg ttcaaatggt caaatttcaa ttgaaaattt tatttctcaa   180
aaaaatgaag atgctggttt gttaattact tctttaggtt cgatccttct tgaagcttct   240
ttctttatca atgtagtatc tagtttacct gatgtaactc ttgattttaa agaaattgaa   300
caaaatcaaa ttgttttaac cagtggcaaa tcagaaatta ccctaaaagg aaaagatagc   360
gaacaatatc cacgaatcca agaaatttca gcaagcactc ctttaatact tgaaacaaaa   420
ttactcaaga aaattattaa tgaaacagcc tttgctgcaa gtacacaaga gagtcgtccg   480
attttaacag gtgtccactt cgtattgagt caacacaaag agttaaaaac agttgcaaca   540
gactctcatc gcctaagcca gaaaaaattg actcttgaaa aaaatagtga tgattttgat   600
gtcgtaattc ctagccgttc tctacgcgaa ttttcagcgg tatttacaga tgatatcgaa   660
actgtagaga ttttctttgc caataaccaa atcctcttta gaagcgaaaa tattagcttc   720
tatactcgtc tcctagaagg aaactatcct gatacagatc gcttgattcc aacagacttt   780
aacactacta ttacttttaa tgtggtaaac ttacgccagt caatggagcg tgcccgtctt   840
ttatcaagtg cgactcaaaa tggtactgtg aaacttgaaa ttaaggatgg ggttgttagc   900
gcccatgttc actctccaga agttggtaaa gtaaacgaag aaatcgatac tgatcaggtt   960
actggtgaag atttgaccat tagtttcaac ccaacttact tgattgattc tcttaaagct   1020
ttaaatagcg aaaaggtgac tattagcttt atctcagctg ttcgtccatt tactcttgtg   1080
ccagcagata ctgacgaaga cttcatgcag ctcattacac cagttcgtac aaat         1134

<210>   4704
<211>   378
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA polymerase III, beta subunit (dnaN)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902046 (0.E+01)

<400>   4704
Met Ile His Phe Ser Ile Asn Lys Asn Leu Phe Leu Gln Ala Leu Asn 
1               5                   10                  15      

Thr Thr Lys Arg Ala Ile Ser Ser Lys Asn Ala Ile Pro Ile Leu Ser 
            20                  25                  30          

Thr Val Lys Ile Asp Val Thr Asn Glu Gly Ile Thr Leu Ile Gly Ser 
        35                  40                  45              

Asn Gly Gln Ile Ser Ile Glu Asn Phe Ile Ser Gln Lys Asn Glu Asp 
    50                  55                  60                  

Ala Gly Leu Leu Ile Thr Ser Leu Gly Ser Ile Leu Leu Glu Ala Ser 
65                  70                  75                  80  

Phe Phe Ile Asn Val Val Ser Ser Leu Pro Asp Val Thr Leu Asp Phe 
                85                  90                  95      

Lys Glu Ile Glu Gln Asn Gln Ile Val Leu Thr Ser Gly Lys Ser Glu 
            100                 105                 110         

Ile Thr Leu Lys Gly Lys Asp Ser Glu Gln Tyr Pro Arg Ile Gln Glu 
        115                 120                 125             

Ile Ser Ala Ser Thr Pro Leu Ile Leu Glu Thr Lys Leu Leu Lys Lys 
    130                 135                 140                 

Ile Ile Asn Glu Thr Ala Phe Ala Ala Ser Thr Gln Glu Ser Arg Pro 
145                 150                 155                 160 

Ile Leu Thr Gly Val His Phe Val Leu Ser Gln His Lys Glu Leu Lys 
                165                 170                 175     

Thr Val Ala Thr Asp Ser His Arg Leu Ser Gln Lys Lys Leu Thr Leu 
            180                 185                 190         

Glu Lys Asn Ser Asp Asp Phe Asp Val Val Ile Pro Ser Arg Ser Leu 
        195                 200                 205             

Arg Glu Phe Ser Ala Val Phe Thr Asp Asp Ile Glu Thr Val Glu Ile 
    210                 215                 220                 

Phe Phe Ala Asn Asn Gln Ile Leu Phe Arg Ser Glu Asn Ile Ser Phe 
225                 230                 235                 240 

Tyr Thr Arg Leu Leu Glu Gly Asn Tyr Pro Asp Thr Asp Arg Leu Ile 
                245                 250                 255     

Pro Thr Asp Phe Asn Thr Thr Ile Thr Phe Asn Val Val Asn Leu Arg 
            260                 265                 270         

Gln Ser Met Glu Arg Ala Arg Leu Leu Ser Ser Ala Thr Gln Asn Gly 
        275                 280                 285             

Thr Val Lys Leu Glu Ile Lys Asp Gly Val Val Ser Ala His Val His 
    290                 295                 300                 

Ser Pro Glu Val Gly Lys Val Asn Glu Glu Ile Asp Thr Asp Gln Val 
305                 310                 315                 320 

Thr Gly Glu Asp Leu Thr Ile Ser Phe Asn Pro Thr Tyr Leu Ile Asp 
                325                 330                 335     

Ser Leu Lys Ala Leu Asn Ser Glu Lys Val Thr Ile Ser Phe Ile Ser 
            340                 345                 350         

Ala Val Arg Pro Phe Thr Leu Val Pro Ala Asp Thr Asp Glu Asp Phe 
        355                 360                 365             

Met Gln Leu Ile Thr Pro Val Arg Thr Asn 
    370                 375             

<210>   4705
<211>   246
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4705
ttgagcctgg ctcgcctctt ttatgatata atcgaaaaag aaaaggagag tagtatgtat   60
caagttggaa attttgttga gatgaaaaaa tcacacgctt gtacaatcaa gtcgactggt   120
aaaaaggcta atcgttggga aattacacgt gtaggagcag atatcaaaat aaaatgtagt   180
aattgtgagc atgttgtcat gatggggcga tatgattttg agcgaaaaat gaataaaatt   240
attgac                                                              246

<210>   4706
<211>   82
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902047 (5.E-34)

<400>   4706
Met Ser Leu Ala Arg Leu Phe Tyr Asp Ile Ile Glu Lys Glu Lys Glu 
1               5                   10                  15      

Ser Ser Met Tyr Gln Val Gly Asn Phe Val Glu Met Lys Lys Ser His 
            20                  25                  30          

Ala Cys Thr Ile Lys Ser Thr Gly Lys Lys Ala Asn Arg Trp Glu Ile 
        35                  40                  45              

Thr Arg Val Gly Ala Asp Ile Lys Ile Lys Cys Ser Asn Cys Glu His 
    50                  55                  60                  

Val Val Met Met Gly Arg Tyr Asp Phe Glu Arg Lys Met Asn Lys Ile 
65                  70                  75                  80  

Ile Asp 
        

<210>   4707
<211>   1122
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4707
atgagaaata tggctttgac agcaggtatc gttggtttgc caaacgttgg taaatcaaca   60
ctatttaatg caattacaaa agcaggagca gaggcagcaa actacccatt tgcgacgatt   120
gatccaaatg ttggaatggt ggaagttcca gatgaacgcc tacaaaaact aactgaaatg   180
ataactccta aaaagacagt tcccacaaca tttgaattta cagatattgc agggattgta   240
aaaggagctt caaaaggaga ggggctaggg aataaattct tggccaatat tcgtgaagta   300
gatgcgattg ttcacgtagt tcgtgctttt gatgatgaaa atgtaatgcg cgagcaagga   360
cgtgaagacg cctttgtaga tccacttgca gatattgata ccattaatct ggaattgatt   420
cttgctgact tagaatcagt gaacaaacga tatgcgcgtg tagaaaagat ggcacgtacg   480
caaaaagata aagaatcagt agcagaattc aatgttcttc aaaagattaa accagtccta   540
gaagacggga aatcagctcg taccattgaa tttacagatg aggaacaaaa ggttgtcaaa   600
ggtcttttcc ttttgacgac taaaccagtt ctttatgtag ctaatgtgga cgaggatgtg   660
gtttcagaac ctgactctat cgactatgtc aaacaaattc gtgaatttgc agcgacagaa   720
aatgctgaag tagtcgttat ttctgcgcgt gctgaggaag aaatttctga attgaatgat   780
gaagataaaa aagagtttct tgaagccatt ggtttgacag aatcaggtgt agataagttg   840
acgcgtgcag cttaccactt gcttggattg ggaacttact tcacagctgg tgaaaaagaa   900
gttcgcgctt ggactttcaa acgtggtatg aaggctcctc aagcagctgg tattatccac   960
tcagactttg aaaaaggctt tattcgtgca gtaaccatgt catatgaaga tctagtgaaa   1020
tacggatctg aaaaggccgt aaaagaagct ggacgcttgc gtgaagaagg aaaagaatat   1080
atcgttcaag atggcgatat catggaattc cgctttaatg tc                      1122

<210>   4708
<211>   374
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   GTP-binding protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902048 (0.E+01)

<400>   4708
Met Arg Asn Met Ala Leu Thr Ala Gly Ile Val Gly Leu Pro Asn Val 
1               5                   10                  15      

Gly Lys Ser Thr Leu Phe Asn Ala Ile Thr Lys Ala Gly Ala Glu Ala 
            20                  25                  30          

Ala Asn Tyr Pro Phe Ala Thr Ile Asp Pro Asn Val Gly Met Val Glu 
        35                  40                  45              

Val Pro Asp Glu Arg Leu Gln Lys Leu Thr Glu Met Ile Thr Pro Lys 
    50                  55                  60                  

Lys Thr Val Pro Thr Thr Phe Glu Phe Thr Asp Ile Ala Gly Ile Val 
65                  70                  75                  80  

Lys Gly Ala Ser Lys Gly Glu Gly Leu Gly Asn Lys Phe Leu Ala Asn 
                85                  90                  95      

Ile Arg Glu Val Asp Ala Ile Val His Val Val Arg Ala Phe Asp Asp 
            100                 105                 110         

Glu Asn Val Met Arg Glu Gln Gly Arg Glu Asp Ala Phe Val Asp Pro 
        115                 120                 125             

Leu Ala Asp Ile Asp Thr Ile Asn Leu Glu Leu Ile Leu Ala Asp Leu 
    130                 135                 140                 

Glu Ser Val Asn Lys Arg Tyr Ala Arg Val Glu Lys Met Ala Arg Thr 
145                 150                 155                 160 

Gln Lys Asp Lys Glu Ser Val Ala Glu Phe Asn Val Leu Gln Lys Ile 
                165                 170                 175     

Lys Pro Val Leu Glu Asp Gly Lys Ser Ala Arg Thr Ile Glu Phe Thr 
            180                 185                 190         

Asp Glu Glu Gln Lys Val Val Lys Gly Leu Phe Leu Leu Thr Thr Lys 
        195                 200                 205             

Pro Val Leu Tyr Val Ala Asn Val Asp Glu Asp Val Val Ser Glu Pro 
    210                 215                 220                 

Asp Ser Ile Asp Tyr Val Lys Gln Ile Arg Glu Phe Ala Ala Thr Glu 
225                 230                 235                 240 

Asn Ala Glu Val Val Val Ile Ser Ala Arg Ala Glu Glu Glu Ile Ser 
                245                 250                 255     

Glu Leu Asn Asp Glu Asp Lys Lys Glu Phe Leu Glu Ala Ile Gly Leu 
            260                 265                 270         

Thr Glu Ser Gly Val Asp Lys Leu Thr Arg Ala Ala Tyr His Leu Leu 
        275                 280                 285             

Gly Leu Gly Thr Tyr Phe Thr Ala Gly Glu Lys Glu Val Arg Ala Trp 
    290                 295                 300                 

Thr Phe Lys Arg Gly Met Lys Ala Pro Gln Ala Ala Gly Ile Ile His 
305                 310                 315                 320 

Ser Asp Phe Glu Lys Gly Phe Ile Arg Ala Val Thr Met Ser Tyr Glu 
                325                 330                 335     

Asp Leu Val Lys Tyr Gly Ser Glu Lys Ala Val Lys Glu Ala Gly Arg 
            340                 345                 350         

Leu Arg Glu Glu Gly Lys Glu Tyr Ile Val Gln Asp Gly Asp Ile Met 
        355                 360                 365             

Glu Phe Arg Phe Asn Val 
    370                 

<210>   4709
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4709
atgaccaaat tacttgtagg cttgggaaat ccaggggata aatattttga aacaaaacac   60
aatgttggtt ttatgttgat tgatcaacta gcgaagaaac agaatgtcac ttttacacac   120
gataagatat ttcaagctga cctagcatcc tttttcctaa atggagaaaa aatttatctg   180
gttaaaccaa cgacctttat gaatgaaagt ggaaaagcag ttcatgcttt attaacttac   240
tatggtttgg atattgacga tttacttatc atttacgatg atcttgacat ggaagttggg   300
aaaattcgtt taagagcaaa aggctcagca ggtggtcata atggtatcaa gtctattatt   360
caacatatag gaactcaggt ctttaaccgt gttaagattg gaattggaag acctaaaaat   420
ggtatgtcag ttgttcatca tgttttgagt aagtttgaca gggatgatta tatcggtatt   480
ttacagtctg ttgacaaagt tgacgattct gtaaactact atttacaaga gaaaaatttt   540
gagaaaacaa tgcagaggta taacgga                                       567

<210>   4710
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   peptidyl-tRNA hydrolase (pth)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902049 (e-107)

<400>   4710
Met Thr Lys Leu Leu Val Gly Leu Gly Asn Pro Gly Asp Lys Tyr Phe 
1               5                   10                  15      

Glu Thr Lys His Asn Val Gly Phe Met Leu Ile Asp Gln Leu Ala Lys 
            20                  25                  30          

Lys Gln Asn Val Thr Phe Thr His Asp Lys Ile Phe Gln Ala Asp Leu 
        35                  40                  45              

Ala Ser Phe Phe Leu Asn Gly Glu Lys Ile Tyr Leu Val Lys Pro Thr 
    50                  55                  60                  

Thr Phe Met Asn Glu Ser Gly Lys Ala Val His Ala Leu Leu Thr Tyr 
65                  70                  75                  80  

Tyr Gly Leu Asp Ile Asp Asp Leu Leu Ile Ile Tyr Asp Asp Leu Asp 
                85                  90                  95      

Met Glu Val Gly Lys Ile Arg Leu Arg Ala Lys Gly Ser Ala Gly Gly 
            100                 105                 110         

His Asn Gly Ile Lys Ser Ile Ile Gln His Ile Gly Thr Gln Val Phe 
        115                 120                 125             

Asn Arg Val Lys Ile Gly Ile Gly Arg Pro Lys Asn Gly Met Ser Val 
    130                 135                 140                 

Val His His Val Leu Ser Lys Phe Asp Arg Asp Asp Tyr Ile Gly Ile 
145                 150                 155                 160 

Leu Gln Ser Val Asp Lys Val Asp Asp Ser Val Asn Tyr Tyr Leu Gln 
                165                 170                 175     

Glu Lys Asn Phe Glu Lys Thr Met Gln Arg Tyr Asn Gly 
            180                 185                 

<210>   4711
<211>   3507
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4711
atggtgacct tattagattt attctcagaa aatgatcaga ttaaaaaatg gcatcaaaat   60
ttaacagata agaaaagaca actaatactt ggtttatcaa catctactaa ggctcttgca   120
attgcaagca gtttagaaaa agaagatagg attgtgttat tgacgtcaac ttatggagaa   180
gcagaaggac ttgttagtga tcttatttct atcttgggtg aggaactcgt ctatccattt   240
ttggtagatg atgctcctat ggtggagttt ttgatgtctt cacaggaaaa aattatttca   300
cgggttgaag ccttgcgttt tttgactgat tcatctaaga aagggatttt agtttgtaat   360
atcgcagcaa gtcgattgat tttaccgtct cccaatgcat tcaaagatag tattgtaaaa   420
atctcagttg gtgaagaata tgatcaacac gcgtttatcc atcagttaaa ggaaaatggc   480
tatcgaaaag ttactcaagt acaaactcag ggcgaattta gtcttcgagg agatatttta   540
gatatttttg aaatatccca gttagaacct tgtcgaattg agttttttgg tgatgaaatt   600
gatggtatca ggtcatttga agtagaaaca caattatcga aagaaaataa gacagaactc   660
actatctttc cagctagtga tatgcttttg agagaaaagg attatcaacg aggacagtca   720
gctttagaaa aacaaatttc aaaaacttta tcacctattt tgaaatcata cctagaagaa   780
attctttcaa gttttcacca aaaacaaagt catgcagact ctcggaagtt tttatctttg   840
tgctatgata agacatggac tgtctttgat tatattgaaa aagatactcc aatattcttt   900
gatgattatc aaaaattgat gaatcagtat gaagtctttg aaagagactt agcgcagtac   960
tttacagaag aattacagaa tagtaaagca ttttctgata tgcagtattt ttctgatatt   1020
gaacaaatct ataaaaaaca aagtccagtg acctttttct ctaatcttca aaagggttta   1080
ggaaatctca aatttgacaa aatttatcaa ttcaatcaat atcctatgca ggaatttttc   1140
aatcagtttt cttttctaaa agaagaaatt gaacgatata aaaaaatgga ttacaccatt   1200
attctgcagt ctagcaattc aatgggaagt aaaacattgg aggatatgtt agaggaatat   1260
cagattaaat tggattctag agataagaca aatatctgta aagaatctgt aaacttaata   1320
gagggtaatc tcagacatgg ttttcatttt gtagatgaaa agattttatt gataactgaa   1380
catgagattt ttcaaaagaa attaaagcgt cgttttcgaa gacaacatgt ttcaaatgca   1440
gagagattaa aagattacaa tgaacttgaa aaaggggact atgttgtcca tcatatccat   1500
gggattggtc aatatctagg aattgaaacc attgaaatca agggaattca tcgcgattat   1560
gtcagtgtcc aataccaaaa tggtgatcaa atttctatcc ccgtggaaca gattcatcta   1620
ctgtccaaat atatttcaag tgatggtaaa gctccaaaac tcaataaatt aaatgacggt   1680
cattttaaaa aggccaagca aaaggttaag aaccaggtag aggatatagc tgatgattta   1740
atcaaactct actctgaacg tagtcagttg aagggttttg ctttctcagc tgatgatgat   1800
gatcaagatg cctttgatga tgctttccct tatgttgaaa cggatgatca acttcgtagt   1860
attgaggaaa tcaagaggga tatgcaggct tctcagccaa tggatcgact tttagttggg   1920
gatgttggtt ttggaaagac tgaagttgct atgcgtgcag cctttaaagc agtcaatgat   1980
cacaaacagg ttgtcattct agttccgacg acggttttag cgcaacagca ctatacgaat   2040
tttaaggaac gattccaaaa ttttgcagtt aatattgatg tgttgagtcg ctttagaagt   2100
aaaaaagagc agactgcaac acttgaaaaa ttgaaaaacg gtcaagtcga tattttgatt   2160
ggaacacatc gtgttttgtc aaaagatgtt gtgtttgctg atttgggctt gatgattatt   2220
gatgaggaac agcgatttgg tgtcaagcat aaggaaactt tgaaagaact gaagaaacaa   2280
gtggatgtcc taaccttgac cgctacgcca atccctcgta ccctccatat gtctatgctg   2340
ggaatcagag atttatctgt tattgaaact ccgccgacta atcgctatcc tgttcagacc   2400
tatgttttgg aaaagaatga tagtgtcatt cgtgatgctg tcttgcgtga aatggagcgt   2460
ggaggtcaag tttattatct ttacaacaaa gttgacacaa ttgttcagaa ggtttcagaa   2520
ttacaggagt tgattccgga ggcttcgatt ggatatgttc atggtcgaat gagtgaagtc   2580
cagttggaaa atactctatt agactttatt gagggacaat acgatatctt ggtgacgact   2640
actattattg agacaggggt ggacattcca aatgctaata ctttatttat tgaaaatgcg   2700
gaccatatgg gcttgtcaac cttatatcag ttaagaggaa gagtcggtcg tagtaatcgt   2760
attgcttatg cttatctcat gtatcgtcca gaaaaatcaa tcagtgaagt ctctgaaaag   2820
agattagaag cgattaaagg atttacagaa ttgggctctg gctttaagat tgcaatgcga   2880
gatctttcga ttcgtggagc aggaaatctt ttaggaaaat cccagtctgg tttcattgat   2940
tctgttggtt ttgaattgta ttcgcagtta ttagaggaag ctattgctaa acgaaacggt   3000
aatgctaacg ctaacacaag aaccaaaggg aatgctgagt tgattttgca aattgatgcc   3060
tatcttcctg atacttatat ttctgatcaa cgacataaga ttgaaattta caagaaaatt   3120
cgtcaaattg acaaccgtgt caattatgaa gagttacaag aggagttgat agaccgtttt   3180
ggagaatacc cagatgtagt agcctatctg ttagagattg gtttggtcaa atcatacttg   3240
gacaaggtct ttgttcaacg tgtggaaaga aaagataata aaattacaat tcaatttgaa   3300
aaagtcactc aacgactgtt tttagctcaa gattatttta aagctttatc cgtaacgaac   3360
ttaaaagcag gcatcgctga gaataaggga ttaatggagc ttgtatttga tgtccaaaat   3420
aagaaagatt atgaaatttt agaaggtttg ctgatttttg gagaaagttt attagagata   3480
aaagagtcta aggaagaaaa ttccatt                                       3507

<210>   4712
<211>   1169
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcription-repair coupling factor (mfd)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902050 (0.E+01)

<400>   4712
Met Val Thr Leu Leu Asp Leu Phe Ser Glu Asn Asp Gln Ile Lys Lys 
1               5                   10                  15      

Trp His Gln Asn Leu Thr Asp Lys Lys Arg Gln Leu Ile Leu Gly Leu 
            20                  25                  30          

Ser Thr Ser Thr Lys Ala Leu Ala Ile Ala Ser Ser Leu Glu Lys Glu 
        35                  40                  45              

Asp Arg Ile Val Leu Leu Thr Ser Thr Tyr Gly Glu Ala Glu Gly Leu 
    50                  55                  60                  

Val Ser Asp Leu Ile Ser Ile Leu Gly Glu Glu Leu Val Tyr Pro Phe 
65                  70                  75                  80  

Leu Val Asp Asp Ala Pro Met Val Glu Phe Leu Met Ser Ser Gln Glu 
                85                  90                  95      

Lys Ile Ile Ser Arg Val Glu Ala Leu Arg Phe Leu Thr Asp Ser Ser 
            100                 105                 110         

Lys Lys Gly Ile Leu Val Cys Asn Ile Ala Ala Ser Arg Leu Ile Leu 
        115                 120                 125             

Pro Ser Pro Asn Ala Phe Lys Asp Ser Ile Val Lys Ile Ser Val Gly 
    130                 135                 140                 

Glu Glu Tyr Asp Gln His Ala Phe Ile His Gln Leu Lys Glu Asn Gly 
145                 150                 155                 160 

Tyr Arg Lys Val Thr Gln Val Gln Thr Gln Gly Glu Phe Ser Leu Arg 
                165                 170                 175     

Gly Asp Ile Leu Asp Ile Phe Glu Ile Ser Gln Leu Glu Pro Cys Arg 
            180                 185                 190         

Ile Glu Phe Phe Gly Asp Glu Ile Asp Gly Ile Arg Ser Phe Glu Val 
        195                 200                 205             

Glu Thr Gln Leu Ser Lys Glu Asn Lys Thr Glu Leu Thr Ile Phe Pro 
    210                 215                 220                 

Ala Ser Asp Met Leu Leu Arg Glu Lys Asp Tyr Gln Arg Gly Gln Ser 
225                 230                 235                 240 

Ala Leu Glu Lys Gln Ile Ser Lys Thr Leu Ser Pro Ile Leu Lys Ser 
                245                 250                 255     

Tyr Leu Glu Glu Ile Leu Ser Ser Phe His Gln Lys Gln Ser His Ala 
            260                 265                 270         

Asp Ser Arg Lys Phe Leu Ser Leu Cys Tyr Asp Lys Thr Trp Thr Val 
        275                 280                 285             

Phe Asp Tyr Ile Glu Lys Asp Thr Pro Ile Phe Phe Asp Asp Tyr Gln 
    290                 295                 300                 

Lys Leu Met Asn Gln Tyr Glu Val Phe Glu Arg Asp Leu Ala Gln Tyr 
305                 310                 315                 320 

Phe Thr Glu Glu Leu Gln Asn Ser Lys Ala Phe Ser Asp Met Gln Tyr 
                325                 330                 335     

Phe Ser Asp Ile Glu Gln Ile Tyr Lys Lys Gln Ser Pro Val Thr Phe 
            340                 345                 350         

Phe Ser Asn Leu Gln Lys Gly Leu Gly Asn Leu Lys Phe Asp Lys Ile 
        355                 360                 365             

Tyr Gln Phe Asn Gln Tyr Pro Met Gln Glu Phe Phe Asn Gln Phe Ser 
    370                 375                 380                 

Phe Leu Lys Glu Glu Ile Glu Arg Tyr Lys Lys Met Asp Tyr Thr Ile 
385                 390                 395                 400 

Ile Leu Gln Ser Ser Asn Ser Met Gly Ser Lys Thr Leu Glu Asp Met 
                405                 410                 415     

Leu Glu Glu Tyr Gln Ile Lys Leu Asp Ser Arg Asp Lys Thr Asn Ile 
            420                 425                 430         

Cys Lys Glu Ser Val Asn Leu Ile Glu Gly Asn Leu Arg His Gly Phe 
        435                 440                 445             

His Phe Val Asp Glu Lys Ile Leu Leu Ile Thr Glu His Glu Ile Phe 
    450                 455                 460                 

Gln Lys Lys Leu Lys Arg Arg Phe Arg Arg Gln His Val Ser Asn Ala 
465                 470                 475                 480 

Glu Arg Leu Lys Asp Tyr Asn Glu Leu Glu Lys Gly Asp Tyr Val Val 
                485                 490                 495     

His His Ile His Gly Ile Gly Gln Tyr Leu Gly Ile Glu Thr Ile Glu 
            500                 505                 510         

Ile Lys Gly Ile His Arg Asp Tyr Val Ser Val Gln Tyr Gln Asn Gly 
        515                 520                 525             

Asp Gln Ile Ser Ile Pro Val Glu Gln Ile His Leu Leu Ser Lys Tyr 
    530                 535                 540                 

Ile Ser Ser Asp Gly Lys Ala Pro Lys Leu Asn Lys Leu Asn Asp Gly 
545                 550                 555                 560 

His Phe Lys Lys Ala Lys Gln Lys Val Lys Asn Gln Val Glu Asp Ile 
                565                 570                 575     

Ala Asp Asp Leu Ile Lys Leu Tyr Ser Glu Arg Ser Gln Leu Lys Gly 
            580                 585                 590         

Phe Ala Phe Ser Ala Asp Asp Asp Asp Gln Asp Ala Phe Asp Asp Ala 
        595                 600                 605             

Phe Pro Tyr Val Glu Thr Asp Asp Gln Leu Arg Ser Ile Glu Glu Ile 
    610                 615                 620                 

Lys Arg Asp Met Gln Ala Ser Gln Pro Met Asp Arg Leu Leu Val Gly 
625                 630                 635                 640 

Asp Val Gly Phe Gly Lys Thr Glu Val Ala Met Arg Ala Ala Phe Lys 
                645                 650                 655     

Ala Val Asn Asp His Lys Gln Val Val Ile Leu Val Pro Thr Thr Val 
            660                 665                 670         

Leu Ala Gln Gln His Tyr Thr Asn Phe Lys Glu Arg Phe Gln Asn Phe 
        675                 680                 685             

Ala Val Asn Ile Asp Val Leu Ser Arg Phe Arg Ser Lys Lys Glu Gln 
    690                 695                 700                 

Thr Ala Thr Leu Glu Lys Leu Lys Asn Gly Gln Val Asp Ile Leu Ile 
705                 710                 715                 720 

Gly Thr His Arg Val Leu Ser Lys Asp Val Val Phe Ala Asp Leu Gly 
                725                 730                 735     

Leu Met Ile Ile Asp Glu Glu Gln Arg Phe Gly Val Lys His Lys Glu 
            740                 745                 750         

Thr Leu Lys Glu Leu Lys Lys Gln Val Asp Val Leu Thr Leu Thr Ala 
        755                 760                 765             

Thr Pro Ile Pro Arg Thr Leu His Met Ser Met Leu Gly Ile Arg Asp 
    770                 775                 780                 

Leu Ser Val Ile Glu Thr Pro Pro Thr Asn Arg Tyr Pro Val Gln Thr 
785                 790                 795                 800 

Tyr Val Leu Glu Lys Asn Asp Ser Val Ile Arg Asp Ala Val Leu Arg 
                805                 810                 815     

Glu Met Glu Arg Gly Gly Gln Val Tyr Tyr Leu Tyr Asn Lys Val Asp 
            820                 825                 830         

Thr Ile Val Gln Lys Val Ser Glu Leu Gln Glu Leu Ile Pro Glu Ala 
        835                 840                 845             

Ser Ile Gly Tyr Val His Gly Arg Met Ser Glu Val Gln Leu Glu Asn 
    850                 855                 860                 

Thr Leu Leu Asp Phe Ile Glu Gly Gln Tyr Asp Ile Leu Val Thr Thr 
865                 870                 875                 880 

Thr Ile Ile Glu Thr Gly Val Asp Ile Pro Asn Ala Asn Thr Leu Phe 
                885                 890                 895     

Ile Glu Asn Ala Asp His Met Gly Leu Ser Thr Leu Tyr Gln Leu Arg 
            900                 905                 910         

Gly Arg Val Gly Arg Ser Asn Arg Ile Ala Tyr Ala Tyr Leu Met Tyr 
        915                 920                 925             

Arg Pro Glu Lys Ser Ile Ser Glu Val Ser Glu Lys Arg Leu Glu Ala 
    930                 935                 940                 

Ile Lys Gly Phe Thr Glu Leu Gly Ser Gly Phe Lys Ile Ala Met Arg 
945                 950                 955                 960 

Asp Leu Ser Ile Arg Gly Ala Gly Asn Leu Leu Gly Lys Ser Gln Ser 
                965                 970                 975     

Gly Phe Ile Asp Ser Val Gly Phe Glu Leu Tyr Ser Gln Leu Leu Glu 
            980                 985                 990         

Glu Ala Ile Ala Lys Arg Asn Gly Asn Ala Asn Ala Asn Thr Arg Thr 
        995                 1000                1005            

Lys Gly Asn Ala Glu Leu Ile Leu Gln Ile Asp Ala Tyr Leu Pro Asp 
    1010                1015                1020                

Thr Tyr Ile Ser Asp Gln Arg His Lys Ile Glu Ile Tyr Lys Lys Ile 
1025                1030                1035                1040

Arg Gln Ile Asp Asn Arg Val Asn Tyr Glu Glu Leu Gln Glu Glu Leu 
                1045                1050                1055    

Ile Asp Arg Phe Gly Glu Tyr Pro Asp Val Val Ala Tyr Leu Leu Glu 
            1060                1065                1070        

Ile Gly Leu Val Lys Ser Tyr Leu Asp Lys Val Phe Val Gln Arg Val 
        1075                1080                1085            

Glu Arg Lys Asp Asn Lys Ile Thr Ile Gln Phe Glu Lys Val Thr Gln 
    1090                1095                1100                

Arg Leu Phe Leu Ala Gln Asp Tyr Phe Lys Ala Leu Ser Val Thr Asn 
1105                1110                1115                1120

Leu Lys Ala Gly Ile Ala Glu Asn Lys Gly Leu Met Glu Leu Val Phe 
                1125                1130                1135    

Asp Val Gln Asn Lys Lys Asp Tyr Glu Ile Leu Glu Gly Leu Leu Ile 
            1140                1145                1150        

Phe Gly Glu Ser Leu Leu Glu Ile Lys Glu Ser Lys Glu Glu Asn Ser 
        1155                1160                1165            

Ile 
    

<210>   4713
<211>   264
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4713
atgagattag ataaatattt aaaagtatcg cgaattatca agcgtcgtac agtcgcaaag   60
gaagtagcag ataaaggtag aatcaaggtt aatggaatct tggccaaaag ttcaacggac   120
ttgaaagtta atgaccaagt tgaaattcgc tttggcaata agttgctgct tgtaaaagta   180
ctagagatga aagatagtac aaaaaaagaa gatgcagcag gaatgtatga aattatcagt   240
gaaacacggg tagaagaaaa tgtc                                          264

<210>   4714
<211>   88
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   S4 domain protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902051 (7.E-44)

<400>   4714
Met Arg Leu Asp Lys Tyr Leu Lys Val Ser Arg Ile Ile Lys Arg Arg 
1               5                   10                  15      

Thr Val Ala Lys Glu Val Ala Asp Lys Gly Arg Ile Lys Val Asn Gly 
            20                  25                  30          

Ile Leu Ala Lys Ser Ser Thr Asp Leu Lys Val Asn Asp Gln Val Glu 
        35                  40                  45              

Ile Arg Phe Gly Asn Lys Leu Leu Leu Val Lys Val Leu Glu Met Lys 
    50                  55                  60                  

Asp Ser Thr Lys Lys Glu Asp Ala Ala Gly Met Tyr Glu Ile Ile Ser 
65                  70                  75                  80  

Glu Thr Arg Val Glu Glu Asn Val 
                85              

<210>   4715
<211>   366
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4715
atgtctaaaa atattgtaca attgaataat tcttttattc aaaatgaata ccaacgtcgt   60
cgctacctga tgaaagaacg acaaaaacgg aatcgtttta tgggaggggt attgattttg   120
attatgctat tatttatctt gccaactttt aatttagcgc agagttatca gcaattactc   180
caaagacgtc agcaattagc agacttgcaa actcagtatc aaactttgag tgatgaaaag   240
gataaggaga cagcatttgc taccaagttg aaagatgaag attatgctgc taaatataca   300
cgagcgaagt actattattc taagtcgagg gaaaaagttt atacgattcc tgacttgctt   360
caaagg                                                              366

<210>   4716
<211>   122
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902052 (8.E-66)

<400>   4716
Met Ser Lys Asn Ile Val Gln Leu Asn Asn Ser Phe Ile Gln Asn Glu 
1               5                   10                  15      

Tyr Gln Arg Arg Arg Tyr Leu Met Lys Glu Arg Gln Lys Arg Asn Arg 
            20                  25                  30          

Phe Met Gly Gly Val Leu Ile Leu Ile Met Leu Leu Phe Ile Leu Pro 
        35                  40                  45              

Thr Phe Asn Leu Ala Gln Ser Tyr Gln Gln Leu Leu Gln Arg Arg Gln 
    50                  55                  60                  

Gln Leu Ala Asp Leu Gln Thr Gln Tyr Gln Thr Leu Ser Asp Glu Lys 
65                  70                  75                  80  

Asp Lys Glu Thr Ala Phe Ala Thr Lys Leu Lys Asp Glu Asp Tyr Ala 
                85                  90                  95      

Ala Lys Tyr Thr Arg Ala Lys Tyr Tyr Tyr Ser Lys Ser Arg Glu Lys 
            100                 105                 110         

Val Tyr Thr Ile Pro Asp Leu Leu Gln Arg 
        115                 120         

<210>   4717
<211>   120
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4717
atggaaaatt tattagacgt aatagagcaa tttttgagtt tgtcagatga aaagctggaa   60
gaattggctg ataaaaatca attattgcgt ttacaagaag aaaaggaaag gaagaatgcg   120

<210>   4718
<211>   40
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4718
Met Glu Asn Leu Leu Asp Val Ile Glu Gln Phe Leu Ser Leu Ser Asp 
1               5                   10                  15      

Glu Lys Leu Glu Glu Leu Ala Asp Lys Asn Gln Leu Leu Arg Leu Gln 
            20                  25                  30          

Glu Glu Lys Glu Arg Lys Asn Ala 
        35                  40  

<210>   4719
<211>   1266
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4719
atgcgtaaat tcttaattat tttgttgcta ccaagttttt tgaccatttc aaaagtcgtt   60
agcacagaaa aagaagtcgt ctatacttcg aaagaaattt attacctttc acaatctgac   120
tttggtattt attttagaga aaaattaagt tctcccatgg tttatggaga ggttcctgtt   180
tatgcgaatg aagatttagt agtggaatct gggaaattga ctcccaaaac aagttttcaa   240
ataaccgagt ggcgcttaaa taaacaagga attccagtat ttaagctatc aaatcatcaa   300
tttatagctg cggacaaacg atttttatat gatcaatcag aggtaactcc aacaataaaa   360
aaagtatggt tagaatctga ctttaaactg tacaatagtc cttatgattt aaaagaagtg   420
aaatcatcct tatcagctta ttcgcaagta tcaatcgaca agaccatgtt tgtagaagga   480
agagaatttc tacatattga tcaggctgga tgggtagcta aagaatcaac ttctgaagaa   540
gataatcgga tgagtaaagt tcaagaaatg ttatctgaaa aatatcagaa agattctttc   600
tctatttatg ttaagcaact gactactgga aaagaagctg gtatcaatca agatgaaaag   660
atgtatgcag ccagcgtttt gaaactctct tatctctatt atacgcaaga aaaaataaat   720
gagggtcttt atcagttaga tacgactgta aaatacgtat ctgcagtcaa tgattttcca   780
ggttcttata aaccagaggg aagtggtagt cttcctaaaa aagaagataa taaagaatat   840
tctttaaagg atttaattac gaaagtatca aaagaatctg ataatgtagc tcataatcta   900
ttgggatatt acatttcaaa ccaatctgat gccacattca aatccaagat gtctgccatt   960
atgggagatg attgggatcc aaaagaaaaa ttgatttctt ctaagatggc cgggaagttt   1020
atggaagcta tttataatca aaatggattt gtgctagagt ctttgactaa aacagatttt   1080
gatagtcagc gaattgccaa aggtgtttct gttaaagtag ctcataaaat tggagatgcg   1140
gatgaattta agcatgatac gggtgttgtc tatgcagatt ctccatttat tctttctatt   1200
ttcactaaga attctgatta tgatacgatt tctaagatag ccaaggatgt ttatgaggtt   1260
ctaaaa                                                              1266

<210>   4720
<211>   422
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902053 (0.E+01)

<400>   4720
Met Arg Lys Phe Leu Ile Ile Leu Leu Leu Pro Ser Phe Leu Thr Ile 
1               5                   10                  15      

Ser Lys Val Val Ser Thr Glu Lys Glu Val Val Tyr Thr Ser Lys Glu 
            20                  25                  30          

Ile Tyr Tyr Leu Ser Gln Ser Asp Phe Gly Ile Tyr Phe Arg Glu Lys 
        35                  40                  45              

Leu Ser Ser Pro Met Val Tyr Gly Glu Val Pro Val Tyr Ala Asn Glu 
    50                  55                  60                  

Asp Leu Val Val Glu Ser Gly Lys Leu Thr Pro Lys Thr Ser Phe Gln 
65                  70                  75                  80  

Ile Thr Glu Trp Arg Leu Asn Lys Gln Gly Ile Pro Val Phe Lys Leu 
                85                  90                  95      

Ser Asn His Gln Phe Ile Ala Ala Asp Lys Arg Phe Leu Tyr Asp Gln 
            100                 105                 110         

Ser Glu Val Thr Pro Thr Ile Lys Lys Val Trp Leu Glu Ser Asp Phe 
        115                 120                 125             

Lys Leu Tyr Asn Ser Pro Tyr Asp Leu Lys Glu Val Lys Ser Ser Leu 
    130                 135                 140                 

Ser Ala Tyr Ser Gln Val Ser Ile Asp Lys Thr Met Phe Val Glu Gly 
145                 150                 155                 160 

Arg Glu Phe Leu His Ile Asp Gln Ala Gly Trp Val Ala Lys Glu Ser 
                165                 170                 175     

Thr Ser Glu Glu Asp Asn Arg Met Ser Lys Val Gln Glu Met Leu Ser 
            180                 185                 190         

Glu Lys Tyr Gln Lys Asp Ser Phe Ser Ile Tyr Val Lys Gln Leu Thr 
        195                 200                 205             

Thr Gly Lys Glu Ala Gly Ile Asn Gln Asp Glu Lys Met Tyr Ala Ala 
    210                 215                 220                 

Ser Val Leu Lys Leu Ser Tyr Leu Tyr Tyr Thr Gln Glu Lys Ile Asn 
225                 230                 235                 240 

Glu Gly Leu Tyr Gln Leu Asp Thr Thr Val Lys Tyr Val Ser Ala Val 
                245                 250                 255     

Asn Asp Phe Pro Gly Ser Tyr Lys Pro Glu Gly Ser Gly Ser Leu Pro 
            260                 265                 270         

Lys Lys Glu Asp Asn Lys Glu Tyr Ser Leu Lys Asp Leu Ile Thr Lys 
        275                 280                 285             

Val Ser Lys Glu Ser Asp Asn Val Ala His Asn Leu Leu Gly Tyr Tyr 
    290                 295                 300                 

Ile Ser Asn Gln Ser Asp Ala Thr Phe Lys Ser Lys Met Ser Ala Ile 
305                 310                 315                 320 

Met Gly Asp Asp Trp Asp Pro Lys Glu Lys Leu Ile Ser Ser Lys Met 
                325                 330                 335     

Ala Gly Lys Phe Met Glu Ala Ile Tyr Asn Gln Asn Gly Phe Val Leu 
            340                 345                 350         

Glu Ser Leu Thr Lys Thr Asp Phe Asp Ser Gln Arg Ile Ala Lys Gly 
        355                 360                 365             

Val Ser Val Lys Val Ala His Lys Ile Gly Asp Ala Asp Glu Phe Lys 
    370                 375                 380                 

His Asp Thr Gly Val Val Tyr Ala Asp Ser Pro Phe Ile Leu Ser Ile 
385                 390                 395                 400 

Phe Thr Lys Asn Ser Asp Tyr Asp Thr Ile Ser Lys Ile Ala Lys Asp 
                405                 410                 415     

Val Tyr Glu Val Leu Lys 
            420         

<210>   4721
<211>   1275
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4721
atgagggaac cagatttttt aaatcatttt ctcaagaagg gatatttcaa aaagcatgct   60
aaggcggttc tagctctttc tggtggatta gattccatgt ttctatttaa ggtattgtct   120
acttatcaaa aagagttaga gattgaattg attctagctc atgtgaatca taagcagaga   180
attgaatcag attgggaaga aaaggaatta aggaagttgg ctgctgaagc agagcttcct   240
atttatatca gcaatttttc aggagaattt tcagaagcgc gtgcacgaaa ttttcgttat   300
gatttttttc aagaggtcat gaaaaagaca ggtgcgacag ctttagtcac tgcccaccat   360
gctgatgatc aggtggaaac gatttttatg cgcttgattc gaggaactcg cttgcgctat   420
ctatcaggaa ttaaggagaa gcaagtagtc ggagagatag aaatcattcg tcccttcttg   480
cattttcaga aaaaagactt tccatcaatt tttcactttg aagatacatc aaatcaggag   540
aatcattatt ttcgaaatcg tattcgaaat tcttacttac cagaattgga aaaagaaaat   600
cctcgattta gggatgcaat cttaggcatt ggcaatgaaa ttttagatta tgatttggca   660
atagctgaat tatctaacaa tattaatgtg gaagatttac agcagttatt ttcttactct   720
gagtctacac aaagagtttt acttcaaact tatctgaatc gttttccaga tttgaatctt   780
acaaaagctc agtttgctga agttcagcag attttaaaat ctaaaagcca gtatcgtcat   840
ccgattaaaa atggctatga attgataaaa gagtaccaac agtttcagat ttgtaaaatc   900
agtccgcagg ctgatgaaaa ggaagatgaa cttgtgttac actatcaaaa tcaggtagct   960
tatcaaggat atttattttc ttttggactt ccattagaag gtgaattaat tcaacaaata   1020
cctgtttcac gtgaaacatc catacacatt cgtcatcgaa aaacaggaga tgttttgatt   1080
aaaaatgggc atagaaaaaa actcagacgt ttatttattg atttgaaaat ccctatggaa   1140
aagagaaact ctgctcttat tattgagcaa tttggtgaaa ttgtctcaat tttgggaatt   1200
gcgaccaata atttgagtaa aaaaacgaaa aatgatataa tgaacactgt actttatata   1260
gaaaaaatag atagg                                                    1275

<210>   4722
<211>   425
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   MesJ/Ycf62 family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902054 (0.E+01)

<400>   4722
Met Arg Glu Pro Asp Phe Leu Asn His Phe Leu Lys Lys Gly Tyr Phe 
1               5                   10                  15      

Lys Lys His Ala Lys Ala Val Leu Ala Leu Ser Gly Gly Leu Asp Ser 
            20                  25                  30          

Met Phe Leu Phe Lys Val Leu Ser Thr Tyr Gln Lys Glu Leu Glu Ile 
        35                  40                  45              

Glu Leu Ile Leu Ala His Val Asn His Lys Gln Arg Ile Glu Ser Asp 
    50                  55                  60                  

Trp Glu Glu Lys Glu Leu Arg Lys Leu Ala Ala Glu Ala Glu Leu Pro 
65                  70                  75                  80  

Ile Tyr Ile Ser Asn Phe Ser Gly Glu Phe Ser Glu Ala Arg Ala Arg 
                85                  90                  95      

Asn Phe Arg Tyr Asp Phe Phe Gln Glu Val Met Lys Lys Thr Gly Ala 
            100                 105                 110         

Thr Ala Leu Val Thr Ala His His Ala Asp Asp Gln Val Glu Thr Ile 
        115                 120                 125             

Phe Met Arg Leu Ile Arg Gly Thr Arg Leu Arg Tyr Leu Ser Gly Ile 
    130                 135                 140                 

Lys Glu Lys Gln Val Val Gly Glu Ile Glu Ile Ile Arg Pro Phe Leu 
145                 150                 155                 160 

His Phe Gln Lys Lys Asp Phe Pro Ser Ile Phe His Phe Glu Asp Thr 
                165                 170                 175     

Ser Asn Gln Glu Asn His Tyr Phe Arg Asn Arg Ile Arg Asn Ser Tyr 
            180                 185                 190         

Leu Pro Glu Leu Glu Lys Glu Asn Pro Arg Phe Arg Asp Ala Ile Leu 
        195                 200                 205             

Gly Ile Gly Asn Glu Ile Leu Asp Tyr Asp Leu Ala Ile Ala Glu Leu 
    210                 215                 220                 

Ser Asn Asn Ile Asn Val Glu Asp Leu Gln Gln Leu Phe Ser Tyr Ser 
225                 230                 235                 240 

Glu Ser Thr Gln Arg Val Leu Leu Gln Thr Tyr Leu Asn Arg Phe Pro 
                245                 250                 255     

Asp Leu Asn Leu Thr Lys Ala Gln Phe Ala Glu Val Gln Gln Ile Leu 
            260                 265                 270         

Lys Ser Lys Ser Gln Tyr Arg His Pro Ile Lys Asn Gly Tyr Glu Leu 
        275                 280                 285             

Ile Lys Glu Tyr Gln Gln Phe Gln Ile Cys Lys Ile Ser Pro Gln Ala 
    290                 295                 300                 

Asp Glu Lys Glu Asp Glu Leu Val Leu His Tyr Gln Asn Gln Val Ala 
305                 310                 315                 320 

Tyr Gln Gly Tyr Leu Phe Ser Phe Gly Leu Pro Leu Glu Gly Glu Leu 
                325                 330                 335     

Ile Gln Gln Ile Pro Val Ser Arg Glu Thr Ser Ile His Ile Arg His 
            340                 345                 350         

Arg Lys Thr Gly Asp Val Leu Ile Lys Asn Gly His Arg Lys Lys Leu 
        355                 360                 365             

Arg Arg Leu Phe Ile Asp Leu Lys Ile Pro Met Glu Lys Arg Asn Ser 
    370                 375                 380                 

Ala Leu Ile Ile Glu Gln Phe Gly Glu Ile Val Ser Ile Leu Gly Ile 
385                 390                 395                 400 

Ala Thr Asn Asn Leu Ser Lys Lys Thr Lys Asn Asp Ile Met Asn Thr 
                405                 410                 415     

Val Leu Tyr Ile Glu Lys Ile Asp Arg 
            420                 425 

<210>   4723
<211>   540
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4723
atgttagaaa acgatattaa aaaagtcctc gtttcacacg atgaaattac agaagcagct   60
aaaaaactag gtgctcaatt aactaaagac tatgcaggaa aaaatccaat cttagttggg   120
attttaaaag gatctattcc ttttatggct gaattggtca aacatattga tacacatatt   180
gaaatggact tcatgatggt ttctagctac catggtggaa cagcaagtag tggtgttatc   240
aatattaaac aagatgtgac tcaagatatc aaaggaagac atgttctatt tgtagaagat   300
atcattgata caggtcaaac tttgaagaat ttgcgagata tgtttaaaga aagagaagca   360
gcttctgtta aaattgcaac cttgttggat aaaccagaag gacgtgttgt agaaattgag   420
gcagactata cttgctttac tatcccaaat gagtttgtag taggttatgg tttagactac   480
aaagaaaatt atcgtaatct tccttatatt ggagtattga aagaggaagt gtattcaaat   540

<210>   4724
<211>   180
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypoxanthine-guanine phosphoribosyltransferase (hpt)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902055 (e-101)

<400>   4724
Met Leu Glu Asn Asp Ile Lys Lys Val Leu Val Ser His Asp Glu Ile 
1               5                   10                  15      

Thr Glu Ala Ala Lys Lys Leu Gly Ala Gln Leu Thr Lys Asp Tyr Ala 
            20                  25                  30          

Gly Lys Asn Pro Ile Leu Val Gly Ile Leu Lys Gly Ser Ile Pro Phe 
        35                  40                  45              

Met Ala Glu Leu Val Lys His Ile Asp Thr His Ile Glu Met Asp Phe 
    50                  55                  60                  

Met Met Val Ser Ser Tyr His Gly Gly Thr Ala Ser Ser Gly Val Ile 
65                  70                  75                  80  

Asn Ile Lys Gln Asp Val Thr Gln Asp Ile Lys Gly Arg His Val Leu 
                85                  90                  95      

Phe Val Glu Asp Ile Ile Asp Thr Gly Gln Thr Leu Lys Asn Leu Arg 
            100                 105                 110         

Asp Met Phe Lys Glu Arg Glu Ala Ala Ser Val Lys Ile Ala Thr Leu 
        115                 120                 125             

Leu Asp Lys Pro Glu Gly Arg Val Val Glu Ile Glu Ala Asp Tyr Thr 
    130                 135                 140                 

Cys Phe Thr Ile Pro Asn Glu Phe Val Val Gly Tyr Gly Leu Asp Tyr 
145                 150                 155                 160 

Lys Glu Asn Tyr Arg Asn Leu Pro Tyr Ile Gly Val Leu Lys Glu Glu 
                165                 170                 175     

Val Tyr Ser Asn 
            180 

<210>   4725
<211>   1956
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4725
atgaaaaaac aaaataatgg tttaattaaa aatccttttc tatggttatt atttatcttt   60
ttccttgtga caggattcca gtatttctat tctgggaata actcaggagg aagtcagcaa   120
atcaactata ctgagttggt acaagaaatt accgatggta atgtaaaaga attaacttac   180
caaccaaatg gtagtgttat cgaagtttct ggtgtctata aaaatcctaa aacaagtaaa   240
gaagaaacag gtattcagtt tttcacgcca tctgttacta aggtagagaa atttaccagc   300
actattcttc ctgcagatac taccgtatca gaattgcaaa aacttgctac tgaccataaa   360
gcagaagtaa ctgttaagca tgaaagttca agtggtatat ggattaatct actcgtatcc   420
attgtgccat ttggaattct attcttcttc ctattctcta tgatgggaaa tatgggagga   480
ggcaatggcc gtaatccaat gagttttgga cgtagtaagg ctaaagcagc aaataaagaa   540
gatattaaag taagattttc agatgttgct ggagctgagg aagaaaaaca agaactagtt   600
gaagttgttg agttcttaaa agatccaaaa cgattcacaa aacttggagc ccgtattcca   660
gcaggtgttc ttttggaggg acctccgggg acaggtaaaa ctttgcttgc taaggcagtc   720
gctggagaag caggtgttcc attctttagt atctcaggtt ctgactttgt agaaatgttt   780
gtcggagttg gagctagtcg tgttcgctct ctttttgagg atgccaaaaa agcagcacca   840
gctatcatct ttatcgatga aattgatgct gttggacgtc aacgtggagt cggtctcggc   900
ggaggtaatg acgaacgtga acaaaccttg aaccaacttt tgattgagat ggatggtttt   960
gagggaaatg aagggattat cgtcatcgct gcgacaaacc gttcagatgt acttgaccct   1020
gcccttttgc gtccaggacg ttttgataga aaagtattgg ttggtcgtcc tgatgttaaa   1080
ggtcgtgaag caatcttgaa agttcacgct aagaataagc ctttagcaga agatgttgat   1140
ttgaaattag tggctcaaca aactccaggc tttgttggtg ctgatttaga gaatgtcttg   1200
aatgaagcag ctttagttgc tgctcgtcgc aataaatcga taattgatgc ttcagatatt   1260
gatgaagcag aagatagagt tattgctgga ccttctaaga aagataagac agtttcacaa   1320
aaagaacgag aattggttgc ttaccatgag gcaggacata ccattgttgg tctagtcttg   1380
tcgaatgctc gcgttgtcca taaggttaca attgtaccac gcggccgtgc aggcggatac   1440
atgattgcac ttcctaaaga ggatcaaatg cttctatcta aagaagatat gaaagagcaa   1500
ttggctggct taatgggtgg acgtgtagct gaagaaatta tctttaatgt ccaaaccaca   1560
ggagcttcaa acgactttga acaagcgaca caaatggcac gtgcaatggt tacagagtac   1620
ggtatgagtg aaaaacttgg cccagtacaa tatgaaggaa accatgctat gcttggtgca   1680
cagagtcctc aaaaatcaat ttcagaacaa acagcttatg aaattgatga agaggttcgt   1740
tcattattaa atgaggcacg aaataaagct gctgaaatta ttcagtcaaa tcgtgaaact   1800
cacaagttaa ttgcagaagc attattgaaa tacgaaacat tggatagtac acaaattaaa   1860
gctctttacg aaacaggaaa gatgcctgaa gcagtagaag aggaatctca tgcactatcc   1920
tatgatgaag taaagtcaaa aatgaatgac gaaaaa                             1956

<210>   4726
<211>   652
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell division protein FtsH (ftsH)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902056 (0.E+01)

<400>   4726
Met Lys Lys Gln Asn Asn Gly Leu Ile Lys Asn Pro Phe Leu Trp Leu 
1               5                   10                  15      

Leu Phe Ile Phe Phe Leu Val Thr Gly Phe Gln Tyr Phe Tyr Ser Gly 
            20                  25                  30          

Asn Asn Ser Gly Gly Ser Gln Gln Ile Asn Tyr Thr Glu Leu Val Gln 
        35                  40                  45              

Glu Ile Thr Asp Gly Asn Val Lys Glu Leu Thr Tyr Gln Pro Asn Gly 
    50                  55                  60                  

Ser Val Ile Glu Val Ser Gly Val Tyr Lys Asn Pro Lys Thr Ser Lys 
65                  70                  75                  80  

Glu Glu Thr Gly Ile Gln Phe Phe Thr Pro Ser Val Thr Lys Val Glu 
                85                  90                  95      

Lys Phe Thr Ser Thr Ile Leu Pro Ala Asp Thr Thr Val Ser Glu Leu 
            100                 105                 110         

Gln Lys Leu Ala Thr Asp His Lys Ala Glu Val Thr Val Lys His Glu 
        115                 120                 125             

Ser Ser Ser Gly Ile Trp Ile Asn Leu Leu Val Ser Ile Val Pro Phe 
    130                 135                 140                 

Gly Ile Leu Phe Phe Phe Leu Phe Ser Met Met Gly Asn Met Gly Gly 
145                 150                 155                 160 

Gly Asn Gly Arg Asn Pro Met Ser Phe Gly Arg Ser Lys Ala Lys Ala 
                165                 170                 175     

Ala Asn Lys Glu Asp Ile Lys Val Arg Phe Ser Asp Val Ala Gly Ala 
            180                 185                 190         

Glu Glu Glu Lys Gln Glu Leu Val Glu Val Val Glu Phe Leu Lys Asp 
        195                 200                 205             

Pro Lys Arg Phe Thr Lys Leu Gly Ala Arg Ile Pro Ala Gly Val Leu 
    210                 215                 220                 

Leu Glu Gly Pro Pro Gly Thr Gly Lys Thr Leu Leu Ala Lys Ala Val 
225                 230                 235                 240 

Ala Gly Glu Ala Gly Val Pro Phe Phe Ser Ile Ser Gly Ser Asp Phe 
                245                 250                 255     

Val Glu Met Phe Val Gly Val Gly Ala Ser Arg Val Arg Ser Leu Phe 
            260                 265                 270         

Glu Asp Ala Lys Lys Ala Ala Pro Ala Ile Ile Phe Ile Asp Glu Ile 
        275                 280                 285             

Asp Ala Val Gly Arg Gln Arg Gly Val Gly Leu Gly Gly Gly Asn Asp 
    290                 295                 300                 

Glu Arg Glu Gln Thr Leu Asn Gln Leu Leu Ile Glu Met Asp Gly Phe 
305                 310                 315                 320 

Glu Gly Asn Glu Gly Ile Ile Val Ile Ala Ala Thr Asn Arg Ser Asp 
                325                 330                 335     

Val Leu Asp Pro Ala Leu Leu Arg Pro Gly Arg Phe Asp Arg Lys Val 
            340                 345                 350         

Leu Val Gly Arg Pro Asp Val Lys Gly Arg Glu Ala Ile Leu Lys Val 
        355                 360                 365             

His Ala Lys Asn Lys Pro Leu Ala Glu Asp Val Asp Leu Lys Leu Val 
    370                 375                 380                 

Ala Gln Gln Thr Pro Gly Phe Val Gly Ala Asp Leu Glu Asn Val Leu 
385                 390                 395                 400 

Asn Glu Ala Ala Leu Val Ala Ala Arg Arg Asn Lys Ser Ile Ile Asp 
                405                 410                 415     

Ala Ser Asp Ile Asp Glu Ala Glu Asp Arg Val Ile Ala Gly Pro Ser 
            420                 425                 430         

Lys Lys Asp Lys Thr Val Ser Gln Lys Glu Arg Glu Leu Val Ala Tyr 
        435                 440                 445             

His Glu Ala Gly His Thr Ile Val Gly Leu Val Leu Ser Asn Ala Arg 
    450                 455                 460                 

Val Val His Lys Val Thr Ile Val Pro Arg Gly Arg Ala Gly Gly Tyr 
465                 470                 475                 480 

Met Ile Ala Leu Pro Lys Glu Asp Gln Met Leu Leu Ser Lys Glu Asp 
                485                 490                 495     

Met Lys Glu Gln Leu Ala Gly Leu Met Gly Gly Arg Val Ala Glu Glu 
            500                 505                 510         

Ile Ile Phe Asn Val Gln Thr Thr Gly Ala Ser Asn Asp Phe Glu Gln 
        515                 520                 525             

Ala Thr Gln Met Ala Arg Ala Met Val Thr Glu Tyr Gly Met Ser Glu 
    530                 535                 540                 

Lys Leu Gly Pro Val Gln Tyr Glu Gly Asn His Ala Met Leu Gly Ala 
545                 550                 555                 560 

Gln Ser Pro Gln Lys Ser Ile Ser Glu Gln Thr Ala Tyr Glu Ile Asp 
                565                 570                 575     

Glu Glu Val Arg Ser Leu Leu Asn Glu Ala Arg Asn Lys Ala Ala Glu 
            580                 585                 590         

Ile Ile Gln Ser Asn Arg Glu Thr His Lys Leu Ile Ala Glu Ala Leu 
        595                 600                 605             

Leu Lys Tyr Glu Thr Leu Asp Ser Thr Gln Ile Lys Ala Leu Tyr Glu 
    610                 615                 620                 

Thr Gly Lys Met Pro Glu Ala Val Glu Glu Glu Ser His Ala Leu Ser 
625                 630                 635                 640 

Tyr Asp Glu Val Lys Ser Lys Met Asn Asp Glu Lys 
                645                 650         


<210>   4727
<211>   477
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4727
atgattaaag aattgtatga agaagtccaa gggactgtgt ataagtgtag aaatgaatat   60
taccttcatt tatgggaatt gtcggattgg gagcaagaag gcatgctctg cttacatgaa   120
ttgattagta gagaagaagg actggtagac gatattccac gtttaaggaa atatttcaag   180
accaagtttc gaaatcgaat tttagactat atccgtaaac aggaaagtca gaagcgtaga   240
tacgataaag aaccctatga agaagtgggt gagatcagtc atcgtataag tgaggggggt   300
ctctggctag atgattatta tctctttcat gaaacactaa gagattatag aaacaaacaa   360
agtaaagaga aacaagaaga actagaacgc gtcttaagca atgaacgatt tcgagggcgt   420
caaagagtat taagagactt acgcattgtg tttaaggagt ttactatccg tacccac      477

<210>   4728
<211>   159
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator ComX1 (comX1)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903862 (e-100)

<400>   4728
Met Ile Lys Glu Leu Tyr Glu Glu Val Gln Gly Thr Val Tyr Lys Cys 
1               5                   10                  15      

Arg Asn Glu Tyr Tyr Leu His Leu Trp Glu Leu Ser Asp Trp Glu Gln 
            20                  25                  30          

Glu Gly Met Leu Cys Leu His Glu Leu Ile Ser Arg Glu Glu Gly Leu 
        35                  40                  45              

Val Asp Asp Ile Pro Arg Leu Arg Lys Tyr Phe Lys Thr Lys Phe Arg 
    50                  55                  60                  

Asn Arg Ile Leu Asp Tyr Ile Arg Lys Gln Glu Ser Gln Lys Arg Arg 
65                  70                  75                  80  

Tyr Asp Lys Glu Pro Tyr Glu Glu Val Gly Glu Ile Ser His Arg Ile 
                85                  90                  95      

Ser Glu Gly Gly Leu Trp Leu Asp Asp Tyr Tyr Leu Phe His Glu Thr 
            100                 105                 110         

Leu Arg Asp Tyr Arg Asn Lys Gln Ser Lys Glu Lys Gln Glu Glu Leu 
        115                 120                 125             

Glu Arg Val Leu Ser Asn Glu Arg Phe Arg Gly Arg Gln Arg Val Leu 
    130                 135                 140                 

Arg Asp Leu Arg Ile Val Phe Lys Glu Phe Thr Ile Arg Thr His 
145                 150                 155                 

<210>   4729
<211>   171
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4729
ttggttttgt tccttttact tggtggttta gctctcctgt tttctctttt agctttaacc   60
agccataaat ggtattacgt gagatttgga aaacgtgtga tgcttctgtt atactaccta   120
ttcgctcaca ataagagaga acttttttac gaaaatctat tgaatatgcc a            171

<210>   4730
<211>   57
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4730
Met Val Leu Phe Leu Leu Leu Gly Gly Leu Ala Leu Leu Phe Ser Leu 
1               5                   10                  15      

Leu Ala Leu Thr Ser His Lys Trp Tyr Tyr Val Arg Phe Gly Lys Arg 
            20                  25                  30          

Val Met Leu Leu Leu Tyr Tyr Leu Phe Ala His Asn Lys Arg Glu Leu 
        35                  40                  45              

Phe Tyr Glu Asn Leu Leu Asn Met Pro 
    50                  55          

<210>   4731
<211>   414
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4731
atgtggtata atcttcttat ggcatattca atagattttc gtaaaaaagt tctctcttat   60
tgtgagcgaa taggtagtat aacagaagca tcacacgttt tccaaatctc acgtaatacc   120
atttatggct ggttaaagct aaaagagaaa acaggagagc taaaccacca agtaaaagga   180
acaaaaccaa gaaaagttga tagagataga cttaaaaact atcttactga caatccagac   240
gcttatttga ctgaaatagc ttctgaattt ggctgtcatc caactaccat ccactatacg   300
ctcaaagcta tgggctacac tcgaaaaaag aaccacacct actatgaaca agacccagaa   360
aaagtagcct tatttcttaa gaattttaat agtttaaagc acctagcacc tgtt         414

<210>   4732
<211>   138
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1 FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902942 (8.E-63)

<400>   4732
Met Trp Tyr Asn Leu Leu Met Ala Tyr Ser Ile Asp Phe Arg Lys Lys 
1               5                   10                  15      

Val Leu Ser Tyr Cys Glu Arg Ile Gly Ser Ile Thr Glu Ala Ser His 
            20                  25                  30          

Val Phe Gln Ile Ser Arg Asn Thr Ile Tyr Gly Trp Leu Lys Leu Lys 
        35                  40                  45              

Glu Lys Thr Gly Glu Leu Asn His Gln Val Lys Gly Thr Lys Pro Arg 
    50                  55                  60                  

Lys Val Asp Arg Asp Arg Leu Lys Asn Tyr Leu Thr Asp Asn Pro Asp 
65                  70                  75                  80  

Ala Tyr Leu Thr Glu Ile Ala Ser Glu Phe Gly Cys His Pro Thr Thr 
                85                  90                  95      

Ile His Tyr Thr Leu Lys Ala Met Gly Tyr Thr Arg Lys Lys Asn His 
            100                 105                 110         

Thr Tyr Tyr Glu Gln Asp Pro Glu Lys Val Ala Leu Phe Leu Lys Asn 
        115                 120                 125             

Phe Asn Ser Leu Lys His Leu Ala Pro Val 
    130                 135             

<210>   4733
<211>   336
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4733
ttggttgcag gtctaacaaa tggtgaatta atcgctccaa tgacttacga agagacgatg   60
acgagcgact tttttgaagc ttggtttcag aattttctct taccaacatt aaacacacca   120
tcggttatta ttatggataa tgtaagattc catagaatgg ggaagctaga acttttatgc   180
gaagagtttg ggcataaact tttacctctt cctccctact cgcctgagta caatcctatt   240
gagaaaacat gggctcatat caaaaagcac ctcaaaaagg tattaccaag ttgcaatacc   300
ttttacgagg cttttttatc ctgctcttgt ttcaat                             336

<210>   4734
<211>   112
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf2
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903870 (5.E-62)

<400>   4734
Met Val Ala Gly Leu Thr Asn Gly Glu Leu Ile Ala Pro Met Thr Tyr 
1               5                   10                  15      

Glu Glu Thr Met Thr Ser Asp Phe Phe Glu Ala Trp Phe Gln Asn Phe 
            20                  25                  30          

Leu Leu Pro Thr Leu Asn Thr Pro Ser Val Ile Ile Met Asp Asn Val 
        35                  40                  45              

Arg Phe His Arg Met Gly Lys Leu Glu Leu Leu Cys Glu Glu Phe Gly 
    50                  55                  60                  

His Lys Leu Leu Pro Leu Pro Pro Tyr Ser Pro Glu Tyr Asn Pro Ile 
65                  70                  75                  80  

Glu Lys Thr Trp Ala His Ile Lys Lys His Leu Lys Lys Val Leu Pro 
                85                  90                  95      

Ser Cys Asn Thr Phe Tyr Glu Ala Phe Leu Ser Cys Ser Cys Phe Asn 
            100                 105                 110         


<210>   4735
<211>   132
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4735
atgggctcat atcaaaaagc acctcaaaaa ggtattacca agttgcaata ccttttacga   60
ggctttttta tcctgctctt gtttcaattg actatattag aggcgagaca tttttcggtt   120
ctttgtcaac tg                                                       132

<210>   4736
<211>   44
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4736
Met Gly Ser Tyr Gln Lys Ala Pro Gln Lys Gly Ile Thr Lys Leu Gln 
1               5                   10                  15      

Tyr Leu Leu Arg Gly Phe Phe Ile Leu Leu Leu Phe Gln Leu Thr Ile 
            20                  25                  30          

Leu Glu Ala Arg His Phe Ser Val Leu Cys Gln Leu 
        35                  40                  

<210>   4737
<211>   204
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4737
ttgtttaaaa ccttcctcaa agataaagag aaaatcgtca acgcccttca attaccttat   60
tccaacgcca aactggaagc caccaataat ctcatcaaac ttatcaagca caatgccttt   120
ggttttagga actttgaaaa cttcaaaaaa gaaaggacga aatttgtcct ttctagatct   180
tcgctttctt caacccacta cagt                                          204

<210>   4738
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   4738
Met Phe Lys Thr Phe Leu Lys Asp Lys Glu Lys Ile Val Asn Ala Leu 
1               5                   10                  15      

Gln Leu Pro Tyr Ser Asn Ala Lys Leu Glu Ala Thr Asn Asn Leu Ile 
            20                  25                  30          

Lys Leu Ile Lys His Asn Ala Phe Gly Phe Arg Asn Phe Glu Asn Phe 
        35                  40                  45              

Lys Lys Glu Arg Thr Lys Phe Val Leu Ser Arg Ser Ser Leu Ser Ser 
    50                  55                  60                  

Thr His Tyr Ser 
65              

<210>   4739
<211>   348
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4739
atgcacttga ctaataaaga aattctagat aaacttttga gctattccga agactttaaa   60
caccactata atctctatca gctcttgctt ttccacctct gtttcagact ttgtttaaaa   120
ccttcctcaa agataaagag aaaatcgtca acgcccttca attaccttat tccaacgcca   180
aactggaagc caccaataat ctcatcaaac ttatcaagca caatgccttt ggttttagga   240
actttgaaaa cttcaaaaaa gaaaggacga aatttgtcct ttctagatct tcgctttctt   300
caacccacta cagttgacaa agaaccgaaa aatgtctcgc ctctaata                348

<210>   4740
<211>   116
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase

<400>   4740
Met His Leu Thr Asn Lys Glu Ile Leu Asp Lys Leu Leu Ser Tyr Ser 
1               5                   10                  15      

Glu Asp Phe Lys His His Tyr Asn Leu Tyr Gln Leu Leu Leu Phe His 
            20                  25                  30          

Leu Cys Phe Arg Leu Cys Leu Lys Pro Ser Ser Lys Ile Lys Arg Lys 
        35                  40                  45              

Ser Ser Thr Pro Phe Asn Tyr Leu Ile Pro Thr Pro Asn Trp Lys Pro 
    50                  55                  60                  

Pro Ile Ile Ser Ser Asn Leu Ser Ser Thr Met Pro Leu Val Leu Gly 
65                  70                  75                  80  

Thr Leu Lys Thr Ser Lys Lys Lys Gly Arg Asn Leu Ser Phe Leu Asp 
                85                  90                  95      

Leu Arg Phe Leu Gln Pro Thr Thr Val Asp Lys Glu Pro Lys Asn Val 
            100                 105                 110         

Ser Pro Leu Ile 
        115     

<210>   4741
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4741
atgagcttta ttgctcagga ctttgataaa ctcaatatca taactgttct tgagagcaga   60
acacaagcca tcatccgaaa tcccatgaat acaaggctat caagcgctac tggaagctca   120
ttcaacaaga tagtcagaaa c                                             141

<210>   4742
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transposase-related

<400>   4742
Met Ser Phe Ile Ala Gln Asp Phe Asp Lys Leu Asn Ile Ile Thr Val 
1               5                   10                  15      

Leu Glu Ser Arg Thr Gln Ala Ile Ile Arg Asn Pro Met Asn Thr Arg 
            20                  25                  30          

Leu Ser Ser Ala Thr Gly Ser Ser Phe Asn Lys Ile Val Arg Asn 
        35                  40                  45          

<210>   4743
<211>   744
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4743
atggagctcg ctgagacttc tatcgtcaag aagaatcatc aaattccttg tatcatcaac   60
caaaagattg ctcagaagct aattaaaaag acttctatga ccgacattga tcatcagttg   120
tctatttcaa cttcaactgt cattcgcaag aacaatgatt ttcactttga gcatgatttt   180
tcgcgtcttc ctgagattat gtcctaggac gttgaaacag tccggggagt gactgtttca   240
atcgggagat ggagatgagc tttattgctc aggactttga taaactcaat atcataactg   300
ttcttgagag cagaacacaa gccatcatcc gaaatcccat gaatacaagg ctatcaagcg   360
ctactggaag ctcattcaac aagatagtca gaaactgagt gataaacgat tttatcgccc   420
tacttttcgt atgcacttga ctaataaaga aattctagat aaacttttga gctattccga   480
agactttaaa caccactata atctctatca gctcttgctt ttccacctct gtttcagact   540
ttgtttaaaa ccttcctcaa agataaagag aaaatcgtca acgcccttca attaccttat   600
tccaacgcca aactggaagc caccaataat ctcatcaaac ttatcaagca caatgccttt   660
ggttttagga actttgaaaa cttcaaaaaa gaaaggacga aatttgtcct ttctagatct   720
tcgctttctt caacccacta cagt                                          744

<210>   4744
<211>   68
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase, degenerate FRAMESHIFT

<400>   4744
Met Glu Leu Ala Glu Thr Ser Ile Val Lys Lys Asn His Gln Ile Pro 
1               5                   10                  15      

Cys Ile Ile Asn Gln Lys Ile Ala Gln Lys Leu Ile Lys Lys Thr Ser 
            20                  25                  30          

Met Thr Asp Ile Asp His Gln Leu Ser Ile Ser Thr Ser Thr Val Ile 
        35                  40                  45              

Arg Lys Asn Asn Asp Phe His Phe Glu His Asp Phe Ser Arg Leu Pro 
    50                  55                  60                  

Glu Ile Met Ser 
65              

<210>   4745
<211>   240
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4745
ttgattatgt tacaaaaaat ttatgagcag atggctaatt tctatgatag tattgaagaa   60
gagtatggtc ctacatttgg tgataatttt gactgggaac atgttcattt taaattttta   120
atttattatt tagtgagata tggcattggt tgtcgtaagg attttattgt ttaccattat   180
cgtgttgctt atcgtttgta tcttgaaaaa ttggtaatga atcggggttt tatttcttgt   240

<210>   4746
<211>   80
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902064 (6.E-46)

<400>   4746
Met Ile Met Leu Gln Lys Ile Tyr Glu Gln Met Ala Asn Phe Tyr Asp 
1               5                   10                  15      

Ser Ile Glu Glu Glu Tyr Gly Pro Thr Phe Gly Asp Asn Phe Asp Trp 
            20                  25                  30          

Glu His Val His Phe Lys Phe Leu Ile Tyr Tyr Leu Val Arg Tyr Gly 
        35                  40                  45              

Ile Gly Cys Arg Lys Asp Phe Ile Val Tyr His Tyr Arg Val Ala Tyr 
    50                  55                  60                  

Arg Leu Tyr Leu Glu Lys Leu Val Met Asn Arg Gly Phe Ile Ser Cys 
65                  70                  75                  80  


<210>   4747
<211>   1326
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4747
atgtatgtga gaaaggaaga gcctgatggc tcagacaaga ttatgacttc agttgttgtt   60
gtaggtaccc aatggggtga tgaaggtaaa gggaagatta cagacttcct ttcagcgaat   120
gcagaagtga ttgcacgtta ccaaggtggt gataatgctg gtcacacgat tgtgattgac   180
ggtaagaaat ttaagttgca cttgattcca tctgggattt tcttccctga aaaaatatct   240
gtcattggga atggtatggt tgtaaatcct aaatctcttg taaaagagtt gagctatctt   300
catgaggaag gtgtaacaac tgataacttg cgtatttctg atcgtgcgca tgttattttg   360
ccttatcata tcgagttgga tcgcttgcaa gaagaagcta agggcgacaa taagattggt   420
acgacaatta agggaattgg tccagcttat atggacaagg ctgctcgtgt tggaattcgt   480
attgcagatc ttttagataa agatattttc cgtgagcgtt tagaacgtaa ccttgctgaa   540
aagaatcgtc tttttgaaaa attgtatgac agtaaagcga ttgttttcga tgatattttt   600
gaagaatatt acgaatatgg tcaacaaatc aagaaatacg tgatagatac atctgttatc   660
ttgaatgatg cgcttgataa tggcaaacgt gtgctttttg aaggtgcaca aggtgttatg   720
ctagatatcg accaaggtac ttatccattt gttacgtcat caaaccctgt agctggtggt   780
gtgacaattg gttctggtgt cggtccaagc aagattgaca aggttgtagg tgtatgtaaa   840
gcttatacga gtcgtgtagg agatggtcct ttcccaactg agttgtttga tgaagtggga   900
gaacgtatcc gtgaagtggg tcatgaatat ggtacaacaa ctggtcgtcc acgtcgtgta   960
ggttggtttg actcagttgt gatgcgtcat agccgtcgtg tttctggtat tactaacctt   1020
tctttgaact ctattgatgt tttgagcggt ttggatactg tgaaaatctg tgtggcctat   1080
gatcttgacg gtcaacgtat tgactactat ccagctagtc ttgaacaatt gaaacgttgc   1140
aagcctatct atgaagagtt gccaggttgg tcagaagata ttaccggagt tcgcaatttg   1200
gaagatcttc ctgagaatgc gcgtaactat gttcgtcgtg tgagtgaatt ggttggcgtt   1260
cgtatttcta ctttctcagt aggtcctggt cgtgaacaaa caaatatttt agaaagtgtt   1320
tggtcc                                                              1326

<210>   4748
<211>   442
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   adenylosuccinate synthetase (purA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902065 (0.E+01)

<400>   4748
Met Tyr Val Arg Lys Glu Glu Pro Asp Gly Ser Asp Lys Ile Met Thr 
1               5                   10                  15      

Ser Val Val Val Val Gly Thr Gln Trp Gly Asp Glu Gly Lys Gly Lys 
            20                  25                  30          

Ile Thr Asp Phe Leu Ser Ala Asn Ala Glu Val Ile Ala Arg Tyr Gln 
        35                  40                  45              

Gly Gly Asp Asn Ala Gly His Thr Ile Val Ile Asp Gly Lys Lys Phe 
    50                  55                  60                  

Lys Leu His Leu Ile Pro Ser Gly Ile Phe Phe Pro Glu Lys Ile Ser 
65                  70                  75                  80  

Val Ile Gly Asn Gly Met Val Val Asn Pro Lys Ser Leu Val Lys Glu 
                85                  90                  95      

Leu Ser Tyr Leu His Glu Glu Gly Val Thr Thr Asp Asn Leu Arg Ile 
            100                 105                 110         

Ser Asp Arg Ala His Val Ile Leu Pro Tyr His Ile Glu Leu Asp Arg 
        115                 120                 125             

Leu Gln Glu Glu Ala Lys Gly Asp Asn Lys Ile Gly Thr Thr Ile Lys 
    130                 135                 140                 

Gly Ile Gly Pro Ala Tyr Met Asp Lys Ala Ala Arg Val Gly Ile Arg 
145                 150                 155                 160 

Ile Ala Asp Leu Leu Asp Lys Asp Ile Phe Arg Glu Arg Leu Glu Arg 
                165                 170                 175     

Asn Leu Ala Glu Lys Asn Arg Leu Phe Glu Lys Leu Tyr Asp Ser Lys 
            180                 185                 190         

Ala Ile Val Phe Asp Asp Ile Phe Glu Glu Tyr Tyr Glu Tyr Gly Gln 
        195                 200                 205             

Gln Ile Lys Lys Tyr Val Ile Asp Thr Ser Val Ile Leu Asn Asp Ala 
    210                 215                 220                 

Leu Asp Asn Gly Lys Arg Val Leu Phe Glu Gly Ala Gln Gly Val Met 
225                 230                 235                 240 

Leu Asp Ile Asp Gln Gly Thr Tyr Pro Phe Val Thr Ser Ser Asn Pro 
                245                 250                 255     

Val Ala Gly Gly Val Thr Ile Gly Ser Gly Val Gly Pro Ser Lys Ile 
            260                 265                 270         

Asp Lys Val Val Gly Val Cys Lys Ala Tyr Thr Ser Arg Val Gly Asp 
        275                 280                 285             

Gly Pro Phe Pro Thr Glu Leu Phe Asp Glu Val Gly Glu Arg Ile Arg 
    290                 295                 300                 

Glu Val Gly His Glu Tyr Gly Thr Thr Thr Gly Arg Pro Arg Arg Val 
305                 310                 315                 320 

Gly Trp Phe Asp Ser Val Val Met Arg His Ser Arg Arg Val Ser Gly 
                325                 330                 335     

Ile Thr Asn Leu Ser Leu Asn Ser Ile Asp Val Leu Ser Gly Leu Asp 
            340                 345                 350         

Thr Val Lys Ile Cys Val Ala Tyr Asp Leu Asp Gly Gln Arg Ile Asp 
        355                 360                 365             

Tyr Tyr Pro Ala Ser Leu Glu Gln Leu Lys Arg Cys Lys Pro Ile Tyr 
    370                 375                 380                 

Glu Glu Leu Pro Gly Trp Ser Glu Asp Ile Thr Gly Val Arg Asn Leu 
385                 390                 395                 400 

Glu Asp Leu Pro Glu Asn Ala Arg Asn Tyr Val Arg Arg Val Ser Glu 
                405                 410                 415     

Leu Val Gly Val Arg Ile Ser Thr Phe Ser Val Gly Pro Gly Arg Glu 
            420                 425                 430         

Gln Thr Asn Ile Leu Glu Ser Val Trp Ser 
        435                 440         

<210>   4749
<211>   465
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4749
atgtattata cgcttgaaga aaaagaagtc tttatgaggg aggctttgag agaggctgag   60
attgctcttg aacacgatga aattccaatt ggttgtgtga ttgtcaaaga tggggaaatc   120
attggtcgtg ggcataatgc gcgtgaggaa ttacagcgag cggttatgca tgcggaaatt   180
atggctatag aggatgcgaa cttgagtgag gagagctggc gcttgctgga ttgcacactt   240
tttgtgacca ttgaaccttg tgtcatgtgt agtggagcga ttgggcttgc ccgcattcca   300
aatgtggtct atggggctaa aaaccagaaa tttggcgctg ctgggagttt gtacaatatc   360
ttgacagatg agcgtctcaa tcatcgtgtg gaggttgaaa taggaatttt ggaagatgaa   420
tgcgcagcta tcatgcagga tttttttaga aatagacgga aaaaa                   465

<210>   4750
<211>   155
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cytidine/deoxycytidylate deaminase family protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902066 (8.E-86)

<400>   4750
Met Tyr Tyr Thr Leu Glu Glu Lys Glu Val Phe Met Arg Glu Ala Leu 
1               5                   10                  15      

Arg Glu Ala Glu Ile Ala Leu Glu His Asp Glu Ile Pro Ile Gly Cys 
            20                  25                  30          

Val Ile Val Lys Asp Gly Glu Ile Ile Gly Arg Gly His Asn Ala Arg 
        35                  40                  45              

Glu Glu Leu Gln Arg Ala Val Met His Ala Glu Ile Met Ala Ile Glu 
    50                  55                  60                  

Asp Ala Asn Leu Ser Glu Glu Ser Trp Arg Leu Leu Asp Cys Thr Leu 
65                  70                  75                  80  

Phe Val Thr Ile Glu Pro Cys Val Met Cys Ser Gly Ala Ile Gly Leu 
                85                  90                  95      

Ala Arg Ile Pro Asn Val Val Tyr Gly Ala Lys Asn Gln Lys Phe Gly 
            100                 105                 110         

Ala Ala Gly Ser Leu Tyr Asn Ile Leu Thr Asp Glu Arg Leu Asn His 
        115                 120                 125             

Arg Val Glu Val Glu Ile Gly Ile Leu Glu Asp Glu Cys Ala Ala Ile 
    130                 135                 140                 

Met Gln Asp Phe Phe Arg Asn Arg Arg Lys Lys 
145                 150                 155 

<210>   4751
<211>   441
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4751
atgaaaattc gtggttttga attggtttcg agttttacag atgaaaattt attgcccaag   60
cgtgagacag cgcatgcggc tggttacgac ttaaaggttg ctgtgcgtac agttgttgcg   120
ccaggagaga ttgtcttggt tccgacaggg gttaaggctt atatgcagcc gactgaggtt   180
ctctacctct atgatcgttc ttcaaatcct cgtaagaagg gcttggtttt aattaactca   240
gttggagtca ttgatgggga ttattatgga aatcctggaa atgaagggca tatttttgcg   300
cagatgaaga atatcacaga ccaagaggtt gttcttgaag ttggggagcg tattgtccag   360
gctgtttttg ctactttctt aattgcagat ggagatgcag ctgatggcgt tcgaactggt   420
ggatttggat cgacagggca c                                             441

<210>   4752
<211>   147
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   deoxyuridine 5'triphosphate nucleotidohydrolase, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902067 (2.E-81)

<400>   4752
Met Lys Ile Arg Gly Phe Glu Leu Val Ser Ser Phe Thr Asp Glu Asn 
1               5                   10                  15      

Leu Leu Pro Lys Arg Glu Thr Ala His Ala Ala Gly Tyr Asp Leu Lys 
            20                  25                  30          

Val Ala Val Arg Thr Val Val Ala Pro Gly Glu Ile Val Leu Val Pro 
        35                  40                  45              

Thr Gly Val Lys Ala Tyr Met Gln Pro Thr Glu Val Leu Tyr Leu Tyr 
    50                  55                  60                  

Asp Arg Ser Ser Asn Pro Arg Lys Lys Gly Leu Val Leu Ile Asn Ser 
65                  70                  75                  80  

Val Gly Val Ile Asp Gly Asp Tyr Tyr Gly Asn Pro Gly Asn Glu Gly 
                85                  90                  95      

His Ile Phe Ala Gln Met Lys Asn Ile Thr Asp Gln Glu Val Val Leu 
            100                 105                 110         

Glu Val Gly Glu Arg Ile Val Gln Ala Val Phe Ala Thr Phe Leu Ile 
        115                 120                 125             

Ala Asp Gly Asp Ala Ala Asp Gly Val Arg Thr Gly Gly Phe Gly Ser 
    130                 135                 140                 

Thr Gly His 
145         

<210>   4753
<211>   555
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4753
atggcgttcg aactggtgga tttggatcga cagggcacta gaatgaagat tatctttgta   60
cgtcatgggg agccagatta ccgtgagtta gaggagcgtt cttatatagg atttgggata   120
gatttggcac ccttgtctga gatgggacgg cagcaagtcc agaaattgag caaaaatcct   180
ttactctcgt cagctgaaat aatcgtatct tctgcagtca caagagcttt agaaacggct   240
tcgtatgtgg tctgtgctac gggtcttcct ttaagagtag agcctttatt acatgaatgg   300
caggtctata aaacaggaat agaaaacttt gaaacagcta gaagactgtt tttagaaaac   360
aagggggagt tgcttcctaa tagtcctatt caatatgaga cagctacgga aatgaagtct   420
cggtttctag aatgtatgtc taagtatcga gaacatcaga ctgtggtagt tgttgctcat   480
cgaatgctca tgcgccagtt tgtgccaaat gagaagattg atttttgcca agtgattgag   540
tgtgagttag agata                                                    555

<210>   4754
<211>   185
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902068 (7.E-96)

<400>   4754
Met Ala Phe Glu Leu Val Asp Leu Asp Arg Gln Gly Thr Arg Met Lys 
1               5                   10                  15      

Ile Ile Phe Val Arg His Gly Glu Pro Asp Tyr Arg Glu Leu Glu Glu 
            20                  25                  30          

Arg Ser Tyr Ile Gly Phe Gly Ile Asp Leu Ala Pro Leu Ser Glu Met 
        35                  40                  45              

Gly Arg Gln Gln Val Gln Lys Leu Ser Lys Asn Pro Leu Leu Ser Ser 
    50                  55                  60                  

Ala Glu Ile Ile Val Ser Ser Ala Val Thr Arg Ala Leu Glu Thr Ala 
65                  70                  75                  80  

Ser Tyr Val Val Cys Ala Thr Gly Leu Pro Leu Arg Val Glu Pro Leu 
                85                  90                  95      

Leu His Glu Trp Gln Val Tyr Lys Thr Gly Ile Glu Asn Phe Glu Thr 
            100                 105                 110         

Ala Arg Arg Leu Phe Leu Glu Asn Lys Gly Glu Leu Leu Pro Asn Ser 
        115                 120                 125             

Pro Ile Gln Tyr Glu Thr Ala Thr Glu Met Lys Ser Arg Phe Leu Glu 
    130                 135                 140                 

Cys Met Ser Lys Tyr Arg Glu His Gln Thr Val Val Val Val Ala His 
145                 150                 155                 160 

Arg Met Leu Met Arg Gln Phe Val Pro Asn Glu Lys Ile Asp Phe Cys 
                165                 170                 175     

Gln Val Ile Glu Cys Glu Leu Glu Ile 
            180                 185 

<210>   4755
<211>   1191
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4755
atgaaactag ctgaggtgac ttccatcaat gtcaatcgaa ccaagacgga gatggaggaa   60
ttcaaccgtg tgcttggagg cggagtggta ccaggaagtc tcgtccttat cggtggggat   120
cctgggattg ggaaatcaac tcttctccta caagtctcaa cccagttgtc ccaagtgggg   180
acagttctct atgtcagtgg ggaggagtct gcccagcaga ttaaactacg tgcagagcgc   240
ttaggtgata ttgatagtga gttttatctc tatgcagaga ccaatatgca gagtgttcgt   300
gcagaagtgg agcgtatcca gccagacttt ctcattattg attccatcca gaccatcatg   360
tctcctgaga tttcaggggt gcaggggtct gtttctcagg tgcgtgaagt gaccgctgaa   420
ctcatgcagt tggccaagac caataacatt gccatcttta tcgtaggtca tgtgaccaaa   480
gaaggaacct tggctgggcc tcgtatgttg gagcatatgg tggatacggt gctttacttt   540
gaaggggagc gtcaccacac ctttcgtatt ttgagagcgg tcaaaaatcg ttttggttcc   600
actaatgaga ttgggatttt tgagatgcag tcgggcggct tggttgaggt actcaatccg   660
agtcaagttt tcctagaaga gcgtttggat ggggcgactg gttcctccat cgttgtaacc   720
atggaaggga cgcgtccgat tttggcggag gttcaggctt tggtaacacc gaccatgttt   780
ggaaatgcca agcgtactac gacaggactt gattttaacc gtgctagctt gattatggct   840
gttttggaaa aacgggcagg gcttctcttg caaaatcagg atgcctatct caaatctgct   900
ggtggtgtta aattggatga acctgcgatt gacttggctg ttgcagttgc tattgcttcg   960
agctacaaag acaagccaac taatcctcag gaatgttttg tcggagaact gggcttgaca   1020
ggagagattc ggcgcgtgaa tcgtattgag caacgcatca acgaagctgc taaactgggc   1080
tttactaaga tttatgtacc taagaattcc ttgacaggaa tcactctgcc taaggaaatt   1140
caggtcattg gcgtgacaac gattcaggaa gtcttgaaaa aggtctttgc a            1191

<210>   4756
<211>   397
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA repair protein RadA, POINT MUTATION (radA)

<400>   4756
Met Lys Leu Ala Glu Val Thr Ser Ile Asn Val Asn Arg Thr Lys Thr 
1               5                   10                  15      

Glu Met Glu Glu Phe Asn Arg Val Leu Gly Gly Gly Val Val Pro Gly 
            20                  25                  30          

Ser Leu Val Leu Ile Gly Gly Asp Pro Gly Ile Gly Lys Ser Thr Leu 
        35                  40                  45              

Leu Leu Gln Val Ser Thr Gln Leu Ser Gln Val Gly Thr Val Leu Tyr 
    50                  55                  60                  

Val Ser Gly Glu Glu Ser Ala Gln Gln Ile Lys Leu Arg Ala Glu Arg 
65                  70                  75                  80  

Leu Gly Asp Ile Asp Ser Glu Phe Tyr Leu Tyr Ala Glu Thr Asn Met 
                85                  90                  95      

Gln Ser Val Arg Ala Glu Val Glu Arg Ile Gln Pro Asp Phe Leu Ile 
            100                 105                 110         

Ile Asp Ser Ile Gln Thr Ile Met Ser Pro Glu Ile Ser Gly Val Gln 
        115                 120                 125             

Gly Ser Val Ser Gln Val Arg Glu Val Thr Ala Glu Leu Met Gln Leu 
    130                 135                 140                 

Ala Lys Thr Asn Asn Ile Ala Ile Phe Ile Val Gly His Val Thr Lys 
145                 150                 155                 160 

Glu Gly Thr Leu Ala Gly Pro Arg Met Leu Glu His Met Val Asp Thr 
                165                 170                 175     

Val Leu Tyr Phe Glu Gly Glu Arg His His Thr Phe Arg Ile Leu Arg 
            180                 185                 190         

Ala Val Lys Asn Arg Phe Gly Ser Thr Asn Glu Ile Gly Ile Phe Glu 
        195                 200                 205             

Met Gln Ser Gly Gly Leu Val Glu Val Leu Asn Pro Ser Gln Val Phe 
    210                 215                 220                 

Leu Glu Glu Arg Leu Asp Gly Ala Thr Gly Ser Ser Ile Val Val Thr 
225                 230                 235                 240 

Met Glu Gly Thr Arg Pro Ile Leu Ala Glu Val Gln Ala Leu Val Thr 
                245                 250                 255     

Pro Thr Met Phe Gly Asn Ala Lys Arg Thr Thr Thr Gly Leu Asp Phe 
            260                 265                 270         


Asn Arg Ala Ser Leu Ile Met Ala Val Leu Glu Lys Arg Ala Gly Leu 
        275                 280                 285             

Leu Leu Gln Asn Gln Asp Ala Tyr Leu Lys Ser Ala Gly Gly Val Lys 
    290                 295                 300                 

Leu Asp Glu Pro Ala Ile Asp Leu Ala Val Ala Val Ala Ile Ala Ser 
305                 310                 315                 320 

Ser Tyr Lys Asp Lys Pro Thr Asn Pro Gln Glu Cys Phe Val Gly Glu 
                325                 330                 335     

Leu Gly Leu Thr Gly Glu Ile Arg Arg Val Asn Arg Ile Glu Gln Arg 
            340                 345                 350         

Ile Asn Glu Ala Ala Lys Leu Gly Phe Thr Lys Ile Tyr Val Pro Lys 
        355                 360                 365             

Asn Ser Leu Thr Gly Ile Thr Leu Pro Lys Glu Ile Gln Val Ile Gly 
    370                 375                 380                 

Val Thr Thr Ile Gln Glu Val Leu Lys Lys Val Phe Ala 
385                 390                 395         

<210>   4757
<211>   564
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4757
gtgacaaatt ctcttaaaaa tgataagata ggagaaatat ttgactatca aattttcaag   60
gagggaatcg tgtcgtattt tgaacagttt atgcaagcca atcaggctta tgttgcccta   120
catgggcagt taaatctgcc acttaaacct aaaaccagag tagccattgt gacctgtatg   180
gactcacgtt tgcacgttgc gcaagctcta ggtttggcac ttggggatgc tcatattttg   240
cggaatgcag gtggtcgagt gactgaggat atgattcgtt ctctagttat ttcccagcaa   300
caaatgggga caagagaaat tgtggtattg catcatacag actgtggtgc tcagaccttt   360
gaaaatgaac cttttcagga gtatttgaag gaagaattgg gtgtcgatgt gtcagaccag   420
gacttcttgc ccttccaaga tatagaagag agtgtacgcg aggatatgca actgcttatc   480
gagtctcccc taataccaga cgatgtcatt atctctggtg ccatttacaa tgttgataca   540
ggaagtatga cagtcgtaga atta                                          564

<210>   4758
<211>   188
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902070 (3.E-90)

<400>   4758
Met Thr Asn Ser Leu Lys Asn Asp Lys Ile Gly Glu Ile Phe Asp Tyr 
1               5                   10                  15      

Gln Ile Phe Lys Glu Gly Ile Val Ser Tyr Phe Glu Gln Phe Met Gln 
            20                  25                  30          

Ala Asn Gln Ala Tyr Val Ala Leu His Gly Gln Leu Asn Leu Pro Leu 
        35                  40                  45              

Lys Pro Lys Thr Arg Val Ala Ile Val Thr Cys Met Asp Ser Arg Leu 
    50                  55                  60                  

His Val Ala Gln Ala Leu Gly Leu Ala Leu Gly Asp Ala His Ile Leu 
65                  70                  75                  80  

Arg Asn Ala Gly Gly Arg Val Thr Glu Asp Met Ile Arg Ser Leu Val 
                85                  90                  95      

Ile Ser Gln Gln Gln Met Gly Thr Arg Glu Ile Val Val Leu His His 
            100                 105                 110         

Thr Asp Cys Gly Ala Gln Thr Phe Glu Asn Glu Pro Phe Gln Glu Tyr 
        115                 120                 125             

Leu Lys Glu Glu Leu Gly Val Asp Val Ser Asp Gln Asp Phe Leu Pro 
    130                 135                 140                 

Phe Gln Asp Ile Glu Glu Ser Val Arg Glu Asp Met Gln Leu Leu Ile 
145                 150                 155                 160 

Glu Ser Pro Leu Ile Pro Asp Asp Val Ile Ile Ser Gly Ala Ile Tyr 
                165                 170                 175     

Asn Val Asp Thr Gly Ser Met Thr Val Val Glu Leu 
            180                 185             


<210>   4759
<211>   207
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4759
atgaagaaaa gcaatatttt atttattttt attttattgc tatgtattgg tttacagtat   60
gaaaccatct actatacgga cggttcgagg tcaggtgcgg aatatggact aatgggagtt   120
tctatctttc tagctctctt ttacatgatt ccggctcttt attttctctt ccgtattggg   180
aaaaatggga attgccaaag aaggttt                                       207

<210>   4760
<211>   69
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902071 (3.E-30)

<400>   4760
Met Lys Lys Ser Asn Ile Leu Phe Ile Phe Ile Leu Leu Leu Cys Ile 
1               5                   10                  15      

Gly Leu Gln Tyr Glu Thr Ile Tyr Tyr Thr Asp Gly Ser Arg Ser Gly 
            20                  25                  30          

Ala Glu Tyr Gly Leu Met Gly Val Ser Ile Phe Leu Ala Leu Phe Tyr 
        35                  40                  45              

Met Ile Pro Ala Leu Tyr Phe Leu Phe Arg Ile Gly Lys Asn Gly Asn 
    50                  55                  60                  

Cys Gln Arg Arg Phe 
65                  

<210>   4761
<211>   621
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4761
ttgccaaaga aggttttgat tctgtcttta ttgggaggga tgttcctttc aggctggttg   60
tctagttttg ctaatactta tatccatgat ttactggggg ttcttttccc agatagtcca   120
tttttaaatg cctttgaaag tgctattgcg gctcctttgg tagaagaacc cttgaaatta   180
ttgtcacttg tttttgtttt ggctttgatt cctgtgcgaa aattaaaatc tttgttttta   240
cttggaattg cttccggttt gggattccaa atgattaagg atattggtta tattcgtacg   300
gatttgccag agggctttga ctttactatt tcgcgaattt tagagcgtat catctcagga   360
attgcctctc actggacttt ttcaggtcta gctgtagtag gtgtttactt gctttacaga   420
gcctataaag gacagaaggt tggcaagaaa cagggcctta tttttctagg tttagccttg   480
ggaactcact tcttgtttaa ctctcctttt gtggagttgg aaacagagtt gcctttagcg   540
attccagtgg ttacggctat tgctctctat ggtttttatc atgcttattg ctttgttgag   600
aaacacaatg agttgatgac c                                             621

<210>   4762
<211>   207
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902071 (7.E-81)

<400>   4762
Met Pro Lys Lys Val Leu Ile Leu Ser Leu Leu Gly Gly Met Phe Leu 
1               5                   10                  15      

Ser Gly Trp Leu Ser Ser Phe Ala Asn Thr Tyr Ile His Asp Leu Leu 
            20                  25                  30          

Gly Val Leu Phe Pro Asp Ser Pro Phe Leu Asn Ala Phe Glu Ser Ala 
        35                  40                  45              

Ile Ala Ala Pro Leu Val Glu Glu Pro Leu Lys Leu Leu Ser Leu Val 
    50                  55                  60                  

Phe Val Leu Ala Leu Ile Pro Val Arg Lys Leu Lys Ser Leu Phe Leu 
65                  70                  75                  80  

Leu Gly Ile Ala Ser Gly Leu Gly Phe Gln Met Ile Lys Asp Ile Gly 
                85                  90                  95      

Tyr Ile Arg Thr Asp Leu Pro Glu Gly Phe Asp Phe Thr Ile Ser Arg 
            100                 105                 110         

Ile Leu Glu Arg Ile Ile Ser Gly Ile Ala Ser His Trp Thr Phe Ser 
        115                 120                 125             

Gly Leu Ala Val Val Gly Val Tyr Leu Leu Tyr Arg Ala Tyr Lys Gly 
    130                 135                 140                 

Gln Lys Val Gly Lys Lys Gln Gly Leu Ile Phe Leu Gly Leu Ala Leu 
145                 150                 155                 160 

Gly Thr His Phe Leu Phe Asn Ser Pro Phe Val Glu Leu Glu Thr Glu 
                165                 170                 175     

Leu Pro Leu Ala Ile Pro Val Val Thr Ala Ile Ala Leu Tyr Gly Phe 
            180                 185                 190         

Tyr His Ala Tyr Cys Phe Val Glu Lys His Asn Glu Leu Met Thr 
        195                 200                 205         

<210>   4763
<211>   966
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4763
atgtcttttt ctgatttaaa gctgtttgcc ctttcttcta ataaagaatt ggcagaacgt   60
gtggcgcagg agattgggat agagttgggg aaatcaagtg ttcgccaatt ttcagatgga   120
gagattcagg tcaacattga agaatcaatc cgtgggaaac acgtctttat cttacaatca   180
actagttcgc ctgtaaatga caatctgctt gaaattttga ttatggtaga tgctttgaag   240
cgtgcgagtg cagaatctgt caatgttgtc atgccttact atgggtatgc acgtcaggat   300
agaaaggcga gagcgcgtga gccaatcact tcaaaacttg tcgcaaatat gcttgaagta   360
gctggagtgg atcgtttatt gaccatcgac ttgcatgctg cgcaaattca aggattcttt   420
gatattcctg tggatcattt gatgggtgct cctctgattg cagattattt tgagcgtcgt   480
ggtatggttg gttctgacta tgtggttgtc agcccggacc atggaggggt gactcgtgct   540
cgtaagttgg cagaattttt gaaaacatct atcgctatta ttgataaacg tcgtagcgtt   600
gataagatga atactagtga agttatgaat atcatcggta aggttgaagg caagacttgt   660
atcttgattg atgatatgat tgataccgct ggaacgattt gtcatgcggc agatgctctt   720
gcggaagctg gtgctgttga agtctatgca agctgtacgc acccagttct ttctggtcct   780
gctacggaca atatccaaaa atcagctatt aagaaattgg ttgttttgga taccatctat   840
ctgccagaag agcgtttgat tgataagatt gagcagattt caatcgctca tctcctaggg   900
gatgctatcg tacgtattca tgaaaaacga ccactttctc cacttttcga tattgagaaa   960
aaaatt                                                              966

<210>   4764
<211>   322
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribose-phosphate pyrophosphokinase (prsA)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902072 (e-179)

<400>   4764
Met Ser Phe Ser Asp Leu Lys Leu Phe Ala Leu Ser Ser Asn Lys Glu 
1               5                   10                  15      

Leu Ala Glu Arg Val Ala Gln Glu Ile Gly Ile Glu Leu Gly Lys Ser 
            20                  25                  30          

Ser Val Arg Gln Phe Ser Asp Gly Glu Ile Gln Val Asn Ile Glu Glu 
        35                  40                  45              

Ser Ile Arg Gly Lys His Val Phe Ile Leu Gln Ser Thr Ser Ser Pro 
    50                  55                  60                  

Val Asn Asp Asn Leu Leu Glu Ile Leu Ile Met Val Asp Ala Leu Lys 
65                  70                  75                  80  

Arg Ala Ser Ala Glu Ser Val Asn Val Val Met Pro Tyr Tyr Gly Tyr 
                85                  90                  95      

Ala Arg Gln Asp Arg Lys Ala Arg Ala Arg Glu Pro Ile Thr Ser Lys 
            100                 105                 110         

Leu Val Ala Asn Met Leu Glu Val Ala Gly Val Asp Arg Leu Leu Thr 
        115                 120                 125             

Ile Asp Leu His Ala Ala Gln Ile Gln Gly Phe Phe Asp Ile Pro Val 
    130                 135                 140                 

Asp His Leu Met Gly Ala Pro Leu Ile Ala Asp Tyr Phe Glu Arg Arg 
145                 150                 155                 160 

Gly Met Val Gly Ser Asp Tyr Val Val Val Ser Pro Asp His Gly Gly 
                165                 170                 175     

Val Thr Arg Ala Arg Lys Leu Ala Glu Phe Leu Lys Thr Ser Ile Ala 
            180                 185                 190         

Ile Ile Asp Lys Arg Arg Ser Val Asp Lys Met Asn Thr Ser Glu Val 
        195                 200                 205             

Met Asn Ile Ile Gly Lys Val Glu Gly Lys Thr Cys Ile Leu Ile Asp 
    210                 215                 220                 

Asp Met Ile Asp Thr Ala Gly Thr Ile Cys His Ala Ala Asp Ala Leu 
225                 230                 235                 240 

Ala Glu Ala Gly Ala Val Glu Val Tyr Ala Ser Cys Thr His Pro Val 
                245                 250                 255     

Leu Ser Gly Pro Ala Thr Asp Asn Ile Gln Lys Ser Ala Ile Lys Lys 
            260                 265                 270         

Leu Val Val Leu Asp Thr Ile Tyr Leu Pro Glu Glu Arg Leu Ile Asp 
        275                 280                 285             

Lys Ile Glu Gln Ile Ser Ile Ala His Leu Leu Gly Asp Ala Ile Val 
    290                 295                 300                 

Arg Ile His Glu Lys Arg Pro Leu Ser Pro Leu Phe Asp Ile Glu Lys 
305                 310                 315                 320 

Lys Ile 
        

<210>   4765
<211>   231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4765
atgtttagtc aactacatat gcgagaagaa caagtcttgt tagcacagga ctatgccttg   60
gaaactgcta gggctgaagg ccttgaacaa ggactagagc gtgggaaagt tgaaggaagg   120
gcagaaagga aactttttgc cttcctagac atagtacgcc aaggtcttct gacttctgag   180
gttgccagcc agcaattagg tatgtcagta tctgaatttg aggcactgtt g            231

<210>   4766
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902074 (2.E-36)

<400>   4766
Met Phe Ser Gln Leu His Met Arg Glu Glu Gln Val Leu Leu Ala Gln 
1               5                   10                  15      

Asp Tyr Ala Leu Glu Thr Ala Arg Ala Glu Gly Leu Glu Gln Gly Leu 
            20                  25                  30          

Glu Arg Gly Lys Val Glu Gly Arg Ala Glu Arg Lys Leu Phe Ala Phe 
        35                  40                  45              

Leu Asp Ile Val Arg Gln Gly Leu Leu Thr Ser Glu Val Ala Ser Gln 
    50                  55                  60                  

Gln Leu Gly Met Ser Val Ser Glu Phe Glu Ala Leu Leu 
65                  70                  75          

<210>   4767
<211>   312
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4767
ttgattgcta agaaaatatt cagcaatcca gaaatcactt gtcaatttat tcgcgatatg   60
ctggacttgc cagcaaaaaa tgtgaccatt ttggagggaa gcgatattca cgtattactc   120
tccatgcctt actcggtgca ggatttttat accagtatag acgtcttggc ggagttggat   180
aacggtactc aagtaattat tgagattcaa gtccatcatc agaatttttt catcaatcac   240
ttgtgggctt acctgtgcag tcaggttaat caaaatcttg aaaaaattcg tcagcgagaa   300
ggtgatactc ac                                                       312

<210>   4768
<211>   104
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902075 (1.E-56)

<400>   4768
Met Ile Ala Lys Lys Ile Phe Ser Asn Pro Glu Ile Thr Cys Gln Phe 
1               5                   10                  15      

Ile Arg Asp Met Leu Asp Leu Pro Ala Lys Asn Val Thr Ile Leu Glu 
            20                  25                  30          

Gly Ser Asp Ile His Val Leu Leu Ser Met Pro Tyr Ser Val Gln Asp 
        35                  40                  45              

Phe Tyr Thr Ser Ile Asp Val Leu Ala Glu Leu Asp Asn Gly Thr Gln 
    50                  55                  60                  

Val Ile Ile Glu Ile Gln Val His His Gln Asn Phe Phe Ile Asn His 
65                  70                  75                  80  

Leu Trp Ala Tyr Leu Cys Ser Gln Val Asn Gln Asn Leu Glu Lys Ile 
                85                  90                  95      

Arg Gln Arg Glu Gly Asp Thr His 
            100                 

<210>   4769
<211>   2631
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4769
atggataaga aaaaattatt attgattgat gggtcttctg tagcttttcg ggcgtttttt   60
gcgctgtatc agcagttgga ccgttttaag aatgtggctg gtttgcatac caatgcgatt   120
tatggttttc agttgatgtt gagtcattta ttggagcggg ttgagccgag tcatattttg   180
gtggcttttg atgcgggaaa gacgaccttc cggacagaga tgtatgcgga ctataagggt   240
ggtcgggcca agactcctga tgagtttcgt gagcaatttc ctttcattcg tgagttgctg   300
gatcatatgg ggattcgtca ctatgatctg gctcagtatg aggcggatga catcattggg   360
acgctggata agctagcaga gcaggatggt tttgatatta ctattgtcag tggggacaag   420
gatttgattc agctgacgga tgagcatacg gtggttgaaa tttccaagaa aggtgtggct   480
gagtttgagg cctttacgcc agattacctc atggaagaaa tgggcctcac accagctcag   540
tttatcgatc tcaaggcgct catgggtgat aagtcggata atatccctgg ggtgaccaaa   600
gtcggtgaaa agacgggtat taagctcttg ctggagcatg gttcgcttga ggggatttat   660
gaaaatattg atggaatgaa gacttctaag atgaaggaaa atctcatcaa tgacaaggaa   720
caggcctttt tgtctaaaac actagcgacc attgatacca aggcaccgat tgcgattggt   780
ttagaggact tggtctatag tggtccagat gttgaaaatc ttgggaaatt ctacgatgag   840
atgggcttca aacagctaaa gcaggcttta aatgtgtcgt cagctgatgt gtctgagagt   900
ttggatttta ctattgttga ccaaatcagt caagatatgc tgagtgaaga gtctatcttc   960
cactttgagc tttttggtga gaattaccat acggataatt tggttggatt tgtctggtct   1020
tgtggggata agctctatgc cacagacaag cttgagctgt tgcaagaccc gattttcaag   1080
gatttcttag aaaaaacatc tctgagagtt tatgacttta agaaggttaa agttcttttg   1140
caacgttttg gtgtggattt gcaggcgcct gcttttgaca tccgtttggc taaatacctc   1200
ctttcgactg tggaggacaa tgaaattgcg accatcgcta gtctttatgg tcagacttac   1260
ttggttgatg atgaaacttt ctacggtaag ggtgttaaaa aggccattcc tgaacgtgag   1320
aaattcttgg aacacttagc ttgtaaactt gctgttttgg tagaaacaga gcctatttta   1380
cttgaaaaac tcagcgaaaa tgggcaatta gagcttcttt atgatatgga gcaacctctg   1440
gcttttgtcc ttgccaagat ggaaattgct gggattatgg tcaagaaaga gaccttgctt   1500
gagatgcagg ctgaaaatga gcttgtcatt gaaaaactga ctcaagagat ttacgagctg   1560
gctggtgagg agtttaatgt caactcgcct aagcagttgg gcgtgcttct ctttgagaaa   1620
ttgggacttc ctctagaata cactaagaaa accaagacag gttattcgac agcagtggat   1680
gttttagagc gtctcgctcc tattgctccg attgttaaga aaatcctgga ttaccgtcaa   1740
attgctaaga ttcaatctac ttatgtaatt ggcttgcagg actggatttt ggctgatgga   1800
aagattcata ctcgctatgt gcaggatttg acccagaccg ggcgtttgtc tagtgtggat   1860
ccaaacttgc aaaatattcc tgcccgattg gaacaggggc gcttgattcg gaaggctttt   1920
gtgccagagt gggaggatag tgtgctactc agctctgact attcacagat tgaattgcgc   1980
gttttggcgc atatttctaa ggatgagcac ttgattaagg ccttccaaga gggggcagat   2040
atccatactt cgacagccat gcgggtcttt ggcattgagc gtcctgatga tgtgactgca   2100
aacgaccgtc gcaatgccaa ggcagttaac tttggagtgg tttatgggat ttcagacttt   2160
ggcttgtcta ataatttggg aattagtcgt aaggaagcca aagcctacat tgatacctac   2220
tttgaacgtt ttccaggtat taaaaactac atggatgaag tggtgcggga ggcgcgtgat   2280
aagggctatg tagagaccct ctttaagcgt cgccgtgagt tgccagatat caattcgcgc   2340
aacttcaata ttcgtggttt tgcggagcga actgctatca actcacctat ccagggttcg   2400
gcagcagata ttctcaagat tgccatgatt cagctggata aagccttggt tgcaggtggt   2460
tatcagacta agatgctgtt acaagtgcac gatgaaatcg tccttgaagt gcctaaatct   2520
gaattggtag agatgaaaaa attggtgaaa caaaccatgg aagaagccat tcaactcagt   2580
gttcctctta tcgcagatga gaatgaaggg gcaacctggt acgaggctaa a            2631

<210>   4770
<211>   877
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA polymerase I (polA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902076 (0.E+01)

<400>   4770
Met Asp Lys Lys Lys Leu Leu Leu Ile Asp Gly Ser Ser Val Ala Phe 
1               5                   10                  15      

Arg Ala Phe Phe Ala Leu Tyr Gln Gln Leu Asp Arg Phe Lys Asn Val 
            20                  25                  30          

Ala Gly Leu His Thr Asn Ala Ile Tyr Gly Phe Gln Leu Met Leu Ser 
        35                  40                  45              

His Leu Leu Glu Arg Val Glu Pro Ser His Ile Leu Val Ala Phe Asp 
    50                  55                  60                  

Ala Gly Lys Thr Thr Phe Arg Thr Glu Met Tyr Ala Asp Tyr Lys Gly 
65                  70                  75                  80  

Gly Arg Ala Lys Thr Pro Asp Glu Phe Arg Glu Gln Phe Pro Phe Ile 
                85                  90                  95      

Arg Glu Leu Leu Asp His Met Gly Ile Arg His Tyr Asp Leu Ala Gln 
            100                 105                 110         

Tyr Glu Ala Asp Asp Ile Ile Gly Thr Leu Asp Lys Leu Ala Glu Gln 
        115                 120                 125             

Asp Gly Phe Asp Ile Thr Ile Val Ser Gly Asp Lys Asp Leu Ile Gln 
    130                 135                 140                 

Leu Thr Asp Glu His Thr Val Val Glu Ile Ser Lys Lys Gly Val Ala 
145                 150                 155                 160 

Glu Phe Glu Ala Phe Thr Pro Asp Tyr Leu Met Glu Glu Met Gly Leu 
                165                 170                 175     

Thr Pro Ala Gln Phe Ile Asp Leu Lys Ala Leu Met Gly Asp Lys Ser 
            180                 185                 190         

Asp Asn Ile Pro Gly Val Thr Lys Val Gly Glu Lys Thr Gly Ile Lys 
        195                 200                 205             

Leu Leu Leu Glu His Gly Ser Leu Glu Gly Ile Tyr Glu Asn Ile Asp 
    210                 215                 220                 

Gly Met Lys Thr Ser Lys Met Lys Glu Asn Leu Ile Asn Asp Lys Glu 
225                 230                 235                 240 

Gln Ala Phe Leu Ser Lys Thr Leu Ala Thr Ile Asp Thr Lys Ala Pro 
                245                 250                 255     

Ile Ala Ile Gly Leu Glu Asp Leu Val Tyr Ser Gly Pro Asp Val Glu 
            260                 265                 270         

Asn Leu Gly Lys Phe Tyr Asp Glu Met Gly Phe Lys Gln Leu Lys Gln 
        275                 280                 285             

Ala Leu Asn Val Ser Ser Ala Asp Val Ser Glu Ser Leu Asp Phe Thr 
    290                 295                 300                 

Ile Val Asp Gln Ile Ser Gln Asp Met Leu Ser Glu Glu Ser Ile Phe 
305                 310                 315                 320 

His Phe Glu Leu Phe Gly Glu Asn Tyr His Thr Asp Asn Leu Val Gly 
                325                 330                 335     

Phe Val Trp Ser Cys Gly Asp Lys Leu Tyr Ala Thr Asp Lys Leu Glu 
            340                 345                 350         

Leu Leu Gln Asp Pro Ile Phe Lys Asp Phe Leu Glu Lys Thr Ser Leu 
        355                 360                 365             

Arg Val Tyr Asp Phe Lys Lys Val Lys Val Leu Leu Gln Arg Phe Gly 
    370                 375                 380                 

Val Asp Leu Gln Ala Pro Ala Phe Asp Ile Arg Leu Ala Lys Tyr Leu 
385                 390                 395                 400 

Leu Ser Thr Val Glu Asp Asn Glu Ile Ala Thr Ile Ala Ser Leu Tyr 
                405                 410                 415     

Gly Gln Thr Tyr Leu Val Asp Asp Glu Thr Phe Tyr Gly Lys Gly Val 
            420                 425                 430         

Lys Lys Ala Ile Pro Glu Arg Glu Lys Phe Leu Glu His Leu Ala Cys 
        435                 440                 445             

Lys Leu Ala Val Leu Val Glu Thr Glu Pro Ile Leu Leu Glu Lys Leu 
    450                 455                 460                 

Ser Glu Asn Gly Gln Leu Glu Leu Leu Tyr Asp Met Glu Gln Pro Leu 
465                 470                 475                 480 

Ala Phe Val Leu Ala Lys Met Glu Ile Ala Gly Ile Met Val Lys Lys 
                485                 490                 495     

Glu Thr Leu Leu Glu Met Gln Ala Glu Asn Glu Leu Val Ile Glu Lys 
            500                 505                 510         

Leu Thr Gln Glu Ile Tyr Glu Leu Ala Gly Glu Glu Phe Asn Val Asn 
        515                 520                 525             

Ser Pro Lys Gln Leu Gly Val Leu Leu Phe Glu Lys Leu Gly Leu Pro 
    530                 535                 540                 

Leu Glu Tyr Thr Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ala Val Asp 
545                 550                 555                 560 

Val Leu Glu Arg Leu Ala Pro Ile Ala Pro Ile Val Lys Lys Ile Leu 
                565                 570                 575     

Asp Tyr Arg Gln Ile Ala Lys Ile Gln Ser Thr Tyr Val Ile Gly Leu 
            580                 585                 590         

Gln Asp Trp Ile Leu Ala Asp Gly Lys Ile His Thr Arg Tyr Val Gln 
        595                 600                 605             

Asp Leu Thr Gln Thr Gly Arg Leu Ser Ser Val Asp Pro Asn Leu Gln 
    610                 615                 620                 

Asn Ile Pro Ala Arg Leu Glu Gln Gly Arg Leu Ile Arg Lys Ala Phe 
625                 630                 635                 640 

Val Pro Glu Trp Glu Asp Ser Val Leu Leu Ser Ser Asp Tyr Ser Gln 
                645                 650                 655     

Ile Glu Leu Arg Val Leu Ala His Ile Ser Lys Asp Glu His Leu Ile 
            660                 665                 670         

Lys Ala Phe Gln Glu Gly Ala Asp Ile His Thr Ser Thr Ala Met Arg 
        675                 680                 685             

Val Phe Gly Ile Glu Arg Pro Asp Asp Val Thr Ala Asn Asp Arg Arg 
    690                 695                 700                 

Asn Ala Lys Ala Val Asn Phe Gly Val Val Tyr Gly Ile Ser Asp Phe 
705                 710                 715                 720 

Gly Leu Ser Asn Asn Leu Gly Ile Ser Arg Lys Glu Ala Lys Ala Tyr 
                725                 730                 735     

Ile Asp Thr Tyr Phe Glu Arg Phe Pro Gly Ile Lys Asn Tyr Met Asp 
            740                 745                 750         

Glu Val Val Arg Glu Ala Arg Asp Lys Gly Tyr Val Glu Thr Leu Phe 
        755                 760                 765             

Lys Arg Arg Arg Glu Leu Pro Asp Ile Asn Ser Arg Asn Phe Asn Ile 
    770                 775                 780                 

Arg Gly Phe Ala Glu Arg Thr Ala Ile Asn Ser Pro Ile Gln Gly Ser 
785                 790                 795                 800 

Ala Ala Asp Ile Leu Lys Ile Ala Met Ile Gln Leu Asp Lys Ala Leu 
                805                 810                 815     

Val Ala Gly Gly Tyr Gln Thr Lys Met Leu Leu Gln Val His Asp Glu 
            820                 825                 830         

Ile Val Leu Glu Val Pro Lys Ser Glu Leu Val Glu Met Lys Lys Leu 
        835                 840                 845             

Val Lys Gln Thr Met Glu Glu Ala Ile Gln Leu Ser Val Pro Leu Ile 
    850                 855                 860                 

Ala Asp Glu Asn Glu Gly Ala Thr Trp Tyr Glu Ala Lys 
865                 870                 875         

<210>   4771
<211>   192
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4771
atgagtcaag aatttatcaa tccaagtgat ggcgtgattc gtcagtatct cgcaacgagt   60
aaaacccttg ctgtggtggg tttgtctgac cgtgaagaaa caaccagcaa tcgagtaaca   120
aaggaaatgc aggctcgggg ctataaaatc atcccagtca attcccaagg cggcaggtgg   180
cgaaatcttg gg                                                       192

<210>   4772
<211>   64
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902077 (2.E-79)

<400>   4772
Met Ser Gln Glu Phe Ile Asn Pro Ser Asp Gly Val Ile Arg Gln Tyr 
1               5                   10                  15      

Leu Ala Thr Ser Lys Thr Leu Ala Val Val Gly Leu Ser Asp Arg Glu 
            20                  25                  30          

Glu Thr Thr Ser Asn Arg Val Thr Lys Glu Met Gln Ala Arg Gly Tyr 
        35                  40                  45              

Lys Ile Ile Pro Val Asn Ser Gln Gly Gly Arg Trp Arg Asn Leu Gly 
    50                  55                  60                  


<210>   4773
<211>   291
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4773
gtgttatact caatgaaaat caaagagcaa actaggaaac tagccacggg ctgctcaaaa   60
cactgttttg aggttgcaga tagaactgac gaagtcagct caaaacactg ttttgaggtt   120
gtagatacga ctgacgaagt cagctcaaaa caccgttttg aggttgcaga tagaactgac   180
gaagtcagct caaacaccgt tttgaggttg cagatagaac tgacgaagtc agtaacatat   240
acctacggca aggcgacgtt gacgtggttt gaagagattt tcgaagagta t            291

<210>   4774
<211>   97
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4774
Met Leu Tyr Ser Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Thr 
1               5                   10                  15      

Gly Cys Ser Lys His Cys Phe Glu Val Ala Asp Arg Thr Asp Glu Val 
            20                  25                  30          

Ser Ser Lys His Cys Phe Glu Val Val Asp Thr Thr Asp Glu Val Ser 
        35                  40                  45              

Ser Lys His Arg Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser Ser 
    50                  55                  60                  

Asn Thr Val Leu Arg Leu Gln Ile Glu Leu Thr Lys Ser Val Thr Tyr 
65                  70                  75                  80  

Thr Tyr Gly Lys Ala Thr Leu Thr Trp Phe Glu Glu Ile Phe Glu Glu 
                85                  90                  95      

Tyr 
    

<210>   4775
<211>   1020
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4775
ttggaggttt ttatgtcatt tctatcaaaa aatggagcag gtatcttggc ctgccttctc   60
atttccatcc tatcttggta cttaggagga ttcttccctg tggttggcgc gcccgttttt   120
gccattttca taggcatgct cctacatccc tttctctcgt cctataaaca actggatgct   180
ggtttgacct ttagttccaa gaagttgctc caatatgccg ttgtcttgct tggttttggt   240
ctcaatatct cgcaggtctt cgcagttggc caatcttcac tccctgtcat cctgtccact   300
atctcaatag ctctgattat tgcctacctc ttccagcgtt tctttgccct ggatacaaaa   360
ctggctacct tggttggagt aggttcttct atctgtgggg gttctgccat tgcagcgaca   420
gcgcccgtta ttgatgctaa ggaaaaggaa gtagcccaag ccatttccgt tatctttttc   480
ttcaatgtct tggctgcgct catctttcca accctcggca cctggcttca tctatccaat   540
gaaggcttcg ccctctttgc agggactgcg gtcaacgaca cttcctctgt aacggctgcc   600
gccagcgctt gggacagtct ttaccaaagc aataccctcg agtctgcaac cattgttaaa   660
ctcacacgta ctttggccat tatccctatc acgctctttc tatcctactg gcaaagtcgc   720
caacaagaaa acaagcaaag cctgcaactg aaaaaagtct tcccactttt tatcctttac   780
tttatccttg cctctctcct cactacacta ctcacctctc taggtgtgtc cagtagtttc   840
tttactcctc tcaaagaact ctctaaattc cttattgtca tggccatgag tgctatcggt   900
ctcaaaacca atctggtcgc tatggtcaaa tccagtggaa aatccattct tcttggagcc   960
atctgctgga ttgccatcat cctcaccact cttggtatgc agacccttat cggcattttc   1020

<210>   4776
<211>   340
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   membrane protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902078 (0.E+01)

<400>   4776
Met Glu Val Phe Met Ser Phe Leu Ser Lys Asn Gly Ala Gly Ile Leu 
1               5                   10                  15      

Ala Cys Leu Leu Ile Ser Ile Leu Ser Trp Tyr Leu Gly Gly Phe Phe 
            20                  25                  30          

Pro Val Val Gly Ala Pro Val Phe Ala Ile Phe Ile Gly Met Leu Leu 
        35                  40                  45              

His Pro Phe Leu Ser Ser Tyr Lys Gln Leu Asp Ala Gly Leu Thr Phe 
    50                  55                  60                  

Ser Ser Lys Lys Leu Leu Gln Tyr Ala Val Val Leu Leu Gly Phe Gly 
65                  70                  75                  80  

Leu Asn Ile Ser Gln Val Phe Ala Val Gly Gln Ser Ser Leu Pro Val 
                85                  90                  95      

Ile Leu Ser Thr Ile Ser Ile Ala Leu Ile Ile Ala Tyr Leu Phe Gln 
            100                 105                 110         

Arg Phe Phe Ala Leu Asp Thr Lys Leu Ala Thr Leu Val Gly Val Gly 
        115                 120                 125             

Ser Ser Ile Cys Gly Gly Ser Ala Ile Ala Ala Thr Ala Pro Val Ile 
    130                 135                 140                 

Asp Ala Lys Glu Lys Glu Val Ala Gln Ala Ile Ser Val Ile Phe Phe 
145                 150                 155                 160 

Phe Asn Val Leu Ala Ala Leu Ile Phe Pro Thr Leu Gly Thr Trp Leu 
                165                 170                 175     

His Leu Ser Asn Glu Gly Phe Ala Leu Phe Ala Gly Thr Ala Val Asn 
            180                 185                 190         

Asp Thr Ser Ser Val Thr Ala Ala Ala Ser Ala Trp Asp Ser Leu Tyr 
        195                 200                 205             

Gln Ser Asn Thr Leu Glu Ser Ala Thr Ile Val Lys Leu Thr Arg Thr 
    210                 215                 220                 

Leu Ala Ile Ile Pro Ile Thr Leu Phe Leu Ser Tyr Trp Gln Ser Arg 
225                 230                 235                 240 

Gln Gln Glu Asn Lys Gln Ser Leu Gln Leu Lys Lys Val Phe Pro Leu 
                245                 250                 255     

Phe Ile Leu Tyr Phe Ile Leu Ala Ser Leu Leu Thr Thr Leu Leu Thr 
            260                 265                 270         

Ser Leu Gly Val Ser Ser Ser Phe Phe Thr Pro Leu Lys Glu Leu Ser 
        275                 280                 285             

Lys Phe Leu Ile Val Met Ala Met Ser Ala Ile Gly Leu Lys Thr Asn 
    290                 295                 300                 

Leu Val Ala Met Val Lys Ser Ser Gly Lys Ser Ile Leu Leu Gly Ala 
305                 310                 315                 320 

Ile Cys Trp Ile Ala Ile Ile Leu Thr Thr Leu Gly Met Gln Thr Leu 
                325                 330                 335     

Ile Gly Ile Phe 
            340 

<210>   4777
<211>   1166
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4777
atggacttaa ctaagcgctt taataaacag ttagataaaa ttcaagtttc gttgattcgt   60
cagtttgacc aggctatttc ggagattcct ggggtcttgc gtttgacctt gggggaacct   120
gattttacaa cgccagacca tgtcaaggag gcgggcaagc gagcgattga tcagaaccaa   180
tcctactata cagggatgag tggtctgctg actctacgtc aggcagccag tgactttgtt   240
aaggaaaagt accaactgga ctatgctcct gaaaatgaaa tcttggttac aattggggcg   300
acagaggctt tatctgcgac tttgacggct attttggaag agggagacaa ggtacttttg   360
ccagctcctg cttatccagg ctatgaaccg attgttaact tagttggggc agaaattgtt   420
gagattgata cgactgaaaa tggttttgtc ttgactcctg agatgttgga gaaggccatt   480
ttggagcagg gtgataagct caaggcggtt attctcaact atccagccaa tccgacagga   540
attacctaca gtcgagagca gttagaggcc ttggcagctg ttttacgcaa gtacgaaatt   600
tttgttgtct gtgatgaggt ttactcagaa ttgacctaca caggcgaagc catgtgtctc   660
taggaacgat gttgagagac caggctatta ttatcaatgg tttgtctaaa tcgcatgcca   720
tgacaggttg gcgtttgggg ctgattttcg ctcctgcgac cttcacagcc cagttaatca   780
agagtcacca gtacttggtc actgccgcaa ataccatggc gcaacatgct gcggtagaag   840
ccttgacggc tggtaaaaac gatgcggagc ccatgaagaa ggaatatatc caacgtcggg   900
actatatcat cgaaaaaatg actgctcttg gttttgagat tatcaaacca gacggtgcct   960
tctatatttt tgctaaaatt ccagcgggct acaatcaaga ctcctttgct tttctgaagg   1020
attttgctca gaagaaggcc gttgccttta tccctggtgc agcctttgga cgttacgggg   1080
aaggctacgt ccgcctatct tatgcagcca gcatggagac tatcaaagaa gccatgaaac   1140
gacttgagga gtacatgaga gaagca                                        1166


<210>   4778
<400>   4778
000

<210>   4779
<211>   714
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4779
ttgcttgatt ccaggcttga gcgaaatggt ctccaaagtc tcaaaatcaa tagcttgaaa   60
ttgattgagc agatagggga tattgggatt gagatgacaa cgtctcttat cctcatgata   120
atgctctgga cagaggcagg ctccatattt gaaagaaaag tcaaaagcct gaccaacccg   180
atggcagaag acacactcat taaaattgag gctgattcca aatcgagtca aaatttgaat   240
ttcaaaaata ttggtcaaaa cctgataatc caagcctgct tccatcaact ccaaagtctt   300
ttgcaaaaaa gcaaacaagg gagcatcctg ctgattgtcc tgcaaactag catctgcaag   360
agctgccaca taggtcgcat aggccatgac aaagaggtca ctattaatct tgggaaaagt   420
catgacctca tgatagtctt cgatgtaact gagtccgtca tcattgattc gcaagagaaa   480
tcgtgccagc accaagggct gaataacagg cgccagctta gactgaccag cgtgtttgac   540
aaaaaacatg cgtttgccaa cctgctctgt aaaaattttg acgagcttgt catcctcacg   600
aaaattgcga ttgtaaagca ccaagccttg actcgtgata gactgaatca tgcttctctc   660
atgtactcct caagtcgttt catggcttct ttgatagtct ccatgctggc tgca         714

<210>   4780
<211>   238
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4780
Met Leu Asp Ser Arg Leu Glu Arg Asn Gly Leu Gln Ser Leu Lys Ile 
1               5                   10                  15      

Asn Ser Leu Lys Leu Ile Glu Gln Ile Gly Asp Ile Gly Ile Glu Met 
            20                  25                  30          

Thr Thr Ser Leu Ile Leu Met Ile Met Leu Trp Thr Glu Ala Gly Ser 
        35                  40                  45              

Ile Phe Glu Arg Lys Val Lys Ser Leu Thr Asn Pro Met Ala Glu Asp 
    50                  55                  60                  

Thr Leu Ile Lys Ile Glu Ala Asp Ser Lys Ser Ser Gln Asn Leu Asn 
65                  70                  75                  80  

Phe Lys Asn Ile Gly Gln Asn Leu Ile Ile Gln Ala Cys Phe His Gln 
                85                  90                  95      

Leu Gln Ser Leu Leu Gln Lys Ser Lys Gln Gly Ser Ile Leu Leu Ile 
            100                 105                 110         

Val Leu Gln Thr Ser Ile Cys Lys Ser Cys His Ile Gly Arg Ile Gly 
        115                 120                 125             

His Asp Lys Glu Val Thr Ile Asn Leu Gly Lys Ser His Asp Leu Met 
    130                 135                 140                 

Ile Val Phe Asp Val Thr Glu Ser Val Ile Ile Asp Ser Gln Glu Lys 
145                 150                 155                 160 

Ser Cys Gln His Gln Gly Leu Asn Asn Arg Arg Gln Leu Arg Leu Thr 
                165                 170                 175     

Ser Val Phe Asp Lys Lys His Ala Phe Ala Asn Leu Leu Cys Lys Asn 
            180                 185                 190         

Phe Asp Glu Leu Val Ile Leu Thr Lys Ile Ala Ile Val Lys His Gln 
        195                 200                 205             

Ala Leu Thr Arg Asp Arg Leu Asn His Ala Ser Leu Met Tyr Ser Ser 
    210                 215                 220                 

Ser Arg Phe Met Ala Ser Leu Ile Val Ser Met Leu Ala Ala 
225                 230                 235             

<210>   4781
<211>   768
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4781
atgattcagt ctatcacgag tcaaggcttg gtgctttaca atcgcaattt tcgtgaggat   60
gacaagctcg tcaaaatttt tacagagcag gttggcaaac gcatgttttt tgtcaaacac   120
gctggtcagt ctaagctggc gcctgttatt cagcccttgg tgctggcacg atttctcttg   180
cgaatcaatg atgacggact cagttacatc gaagactatc atgaggtcat gacttttccc   240
aagattaata gtgacctctt tgtcatggcc tatgcgacct atgtggcagc tcttgcagat   300
gctagtttgc aggacaatca gcaggatgct cccttgtttg cttttttgca aaagactttg   360
gagttgatgg aagcaggctt ggattatcag gttttgacca atatttttga aattcaaatt   420
ttgactcgat ttggaatcag cctcaatttt aatgagtgtg tcttctgcca tcgggttggt   480
caggcttttg acttttcttt caaatatgga gcctgcctct gtccagagca ttatcatgag   540
gataagagac gttgtcatct caatcccaat atcccctatc tgctcaatca atttcaagct   600
attgattttg agactttgga gaccatttcg ctcaagcctg gaatcaagca agagctacgc   660
caatttatgg atcaattata tgaagagtac gttgggattc acctaaaatc aaagaaattt   720
attgattccc tagcagactg gggacaatta ctaaaagagg aaaagaaa                768

<210>   4782
<211>   256
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902080 (e-148)

<400>   4782
Met Ile Gln Ser Ile Thr Ser Gln Gly Leu Val Leu Tyr Asn Arg Asn 
1               5                   10                  15      

Phe Arg Glu Asp Asp Lys Leu Val Lys Ile Phe Thr Glu Gln Val Gly 
            20                  25                  30          

Lys Arg Met Phe Phe Val Lys His Ala Gly Gln Ser Lys Leu Ala Pro 
        35                  40                  45              

Val Ile Gln Pro Leu Val Leu Ala Arg Phe Leu Leu Arg Ile Asn Asp 
    50                  55                  60                  

Asp Gly Leu Ser Tyr Ile Glu Asp Tyr His Glu Val Met Thr Phe Pro 
65                  70                  75                  80  

Lys Ile Asn Ser Asp Leu Phe Val Met Ala Tyr Ala Thr Tyr Val Ala 
                85                  90                  95      

Ala Leu Ala Asp Ala Ser Leu Gln Asp Asn Gln Gln Asp Ala Pro Leu 
            100                 105                 110         

Phe Ala Phe Leu Gln Lys Thr Leu Glu Leu Met Glu Ala Gly Leu Asp 
        115                 120                 125             

Tyr Gln Val Leu Thr Asn Ile Phe Glu Ile Gln Ile Leu Thr Arg Phe 
    130                 135                 140                 

Gly Ile Ser Leu Asn Phe Asn Glu Cys Val Phe Cys His Arg Val Gly 
145                 150                 155                 160 


Gln Ala Phe Asp Phe Ser Phe Lys Tyr Gly Ala Cys Leu Cys Pro Glu 
                165                 170                 175     

His Tyr His Glu Asp Lys Arg Arg Cys His Leu Asn Pro Asn Ile Pro 
            180                 185                 190         

Tyr Leu Leu Asn Gln Phe Gln Ala Ile Asp Phe Glu Thr Leu Glu Thr 
        195                 200                 205             

Ile Ser Leu Lys Pro Gly Ile Lys Gln Glu Leu Arg Gln Phe Met Asp 
    210                 215                 220                 

Gln Leu Tyr Glu Glu Tyr Val Gly Ile His Leu Lys Ser Lys Lys Phe 
225                 230                 235                 240 

Ile Asp Ser Leu Ala Asp Trp Gly Gln Leu Leu Lys Glu Glu Lys Lys 
                245                 250                 255     


<210>   4783
<211>   990
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4783
atgaaaaaaa tcgcagtaga tgccatgggg ggcgattacg cacctcaggc cattgttgag   60
ggtgtcaatc aagccctatc tgacttttca gatatcgagg ttcaacttta cggagatgaa   120
gctaaaatca agcaatatct gacagcgaca gagcgcgtca gcattatcca tacggatgag   180
aagattgatt cggatgatga acctacgaga gctattcgga ataagaaaaa tgccagtatg   240
gtattggcag ccaaggctgt caaagatggt gaagcagacg ctgtcctttc ggctgggaat   300
acaggtgcct tgttggcagc aggattcttc atcgtgggtc gtatcaagaa tatcgaccgt   360
cctggactca tgtctacctt gcctaccgtt gatggaaaag gttttgacat gctagacctt   420
ggtgccaatg cagaaaatac agcccagcac ctccatcaat atgcggttct aggttccttc   480
tatgctaaaa atgtccgtgg cattgcgcaa ccacgcgttg gtttgctcaa caacggaaca   540
gagagtagca agggcgaccc gcttcgtaag gaaacttatg aattactggc ggctgatgaa   600
agtttgaact ttatcggaaa cgtggaagcg cgtgatttga tgaatggcgt tgcagatgtt   660
gttgtggcag atggtttcac gggaaacgct gtgctcaaat ccatcgaagg gacagctatg   720
ggaatcatgg gcttgctcaa gacagctatt acaggtggtg gtcttcgagc gaaactaggt   780
gccctccttc tcaaggacag cctcagtggt ttgaaaaaac agctcaatta ttcagatgtt   840
ggtggagcgg tcttgtttgg tgttaaggca cctgttgtca agactcatgg ctcaagcgat   900
gccaaggctg tttatagtac gattcgtcag atccgtacca tgctagaaac agacgtggtt   960
gcccagactg cgcgtgaatt ttcaggagaa                                    990

<210>   4784
<211>   330
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   fatty acid/phospholipid synthesis protein PlsX (plsX)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902081 (0.E+01)

<400>   4784
Met Lys Lys Ile Ala Val Asp Ala Met Gly Gly Asp Tyr Ala Pro Gln 
1               5                   10                  15      

Ala Ile Val Glu Gly Val Asn Gln Ala Leu Ser Asp Phe Ser Asp Ile 
            20                  25                  30          

Glu Val Gln Leu Tyr Gly Asp Glu Ala Lys Ile Lys Gln Tyr Leu Thr 
        35                  40                  45              

Ala Thr Glu Arg Val Ser Ile Ile His Thr Asp Glu Lys Ile Asp Ser 
    50                  55                  60                  

Asp Asp Glu Pro Thr Arg Ala Ile Arg Asn Lys Lys Asn Ala Ser Met 
65                  70                  75                  80  

Val Leu Ala Ala Lys Ala Val Lys Asp Gly Glu Ala Asp Ala Val Leu 
                85                  90                  95      

Ser Ala Gly Asn Thr Gly Ala Leu Leu Ala Ala Gly Phe Phe Ile Val 
            100                 105                 110         

Gly Arg Ile Lys Asn Ile Asp Arg Pro Gly Leu Met Ser Thr Leu Pro 
        115                 120                 125             

Thr Val Asp Gly Lys Gly Phe Asp Met Leu Asp Leu Gly Ala Asn Ala 
    130                 135                 140                 

Glu Asn Thr Ala Gln His Leu His Gln Tyr Ala Val Leu Gly Ser Phe 
145                 150                 155                 160 

Tyr Ala Lys Asn Val Arg Gly Ile Ala Gln Pro Arg Val Gly Leu Leu 
                165                 170                 175     

Asn Asn Gly Thr Glu Ser Ser Lys Gly Asp Pro Leu Arg Lys Glu Thr 

            180                 185                 190         

Tyr Glu Leu Leu Ala Ala Asp Glu Ser Leu Asn Phe Ile Gly Asn Val 
        195                 200                 205             

Glu Ala Arg Asp Leu Met Asn Gly Val Ala Asp Val Val Val Ala Asp 
    210                 215                 220                 

Gly Phe Thr Gly Asn Ala Val Leu Lys Ser Ile Glu Gly Thr Ala Met 
225                 230                 235                 240 

Gly Ile Met Gly Leu Leu Lys Thr Ala Ile Thr Gly Gly Gly Leu Arg 
                245                 250                 255     

Ala Lys Leu Gly Ala Leu Leu Leu Lys Asp Ser Leu Ser Gly Leu Lys 
            260                 265                 270         

Lys Gln Leu Asn Tyr Ser Asp Val Gly Gly Ala Val Leu Phe Gly Val 
        275                 280                 285             

Lys Ala Pro Val Val Lys Thr His Gly Ser Ser Asp Ala Lys Ala Val 
    290                 295                 300                 

Tyr Ser Thr Ile Arg Gln Ile Arg Thr Met Leu Glu Thr Asp Val Val 
305                 310                 315                 320 

Ala Gln Thr Ala Arg Glu Phe Ser Gly Glu 
                325                 330 

<210>   4785
<211>   231
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4785
atgacagaaa aagaaatttt tgaccgtatt gtgaccatta tccaagagcg acagggagag   60
gactttgtcg tgacagaatc cttgagtctg aaagacgatt tggatgcgga ttctgttgac   120
ttgatggagt ttatcttgac tctggaagat gaatttagta tcgaaatcag cgatgaagaa   180
attgaccaac tccaaaacgt aggagatgtg gttaaaatca ttcaaggaaa a            231

<210>   4786
<211>   77
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acyl carrier protein, putative
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902082 (3.E-38)

<400>   4786
Met Thr Glu Lys Glu Ile Phe Asp Arg Ile Val Thr Ile Ile Gln Glu 
1               5                   10                  15      

Arg Gln Gly Glu Asp Phe Val Val Thr Glu Ser Leu Ser Leu Lys Asp 
            20                  25                  30          

Asp Leu Asp Ala Asp Ser Val Asp Leu Met Glu Phe Ile Leu Thr Leu 
        35                  40                  45              

Glu Asp Glu Phe Ser Ile Glu Ile Ser Asp Glu Glu Ile Asp Gln Leu 
    50                  55                  60                  

Gln Asn Val Gly Asp Val Val Lys Ile Ile Gln Gly Lys 
65                  70                  75          

<210>   4787
<211>   291
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4787
atgagaaata tcggacaagc tggtaaaatc ttggctgaca gtggttatca agggctcatg   60
aagatatatc ctcaagcaca aactccacgt aaatccagca aactcaagcc gctaacagtt   120
gaagataaag cctgtaatca tgcgctatct aaggagataa gcaaggttga gaatatcttt   180
gccaaagtaa aaacgtttaa aatgttttca acaacctatc gaaatcatcg taaacgcttc   240
ggattacgaa tgaatttgat tgctggtatt atcaatcatg aactaggatt c            291

<210>   4788
<211>   97
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902083 (1.E-51)

<400>   4788
Met Arg Asn Ile Gly Gln Ala Gly Lys Ile Leu Ala Asp Ser Gly Tyr 
1               5                   10                  15      

Gln Gly Leu Met Lys Ile Tyr Pro Gln Ala Gln Thr Pro Arg Lys Ser 
            20                  25                  30          

Ser Lys Leu Lys Pro Leu Thr Val Glu Asp Lys Ala Cys Asn His Ala 
        35                  40                  45              

Leu Ser Lys Glu Ile Ser Lys Val Glu Asn Ile Phe Ala Lys Val Lys 
    50                  55                  60                  

Thr Phe Lys Met Phe Ser Thr Thr Tyr Arg Asn His Arg Lys Arg Phe 
65                  70                  75                  80  

Gly Leu Arg Met Asn Leu Ile Ala Gly Ile Ile Asn His Glu Leu Gly 
                85                  90                  95      

Phe 
    

<210>   4789
<211>   123
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4789
ttgtcttgtt acaaacttga caagtttagt ataacagtat ctattaattt ttttcatcca   60
aatcttgaat tggcatcgaa acgtcttgaa ttagcttttt tgtttcaaaa tcatctctat   120
ttt                                                                 123

<210>   4790
<211>   41
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4790
Met Ser Cys Tyr Lys Leu Asp Lys Phe Ser Ile Thr Val Ser Ile Asn 
1               5                   10                  15      

Phe Phe His Pro Asn Leu Glu Leu Ala Ser Lys Arg Leu Glu Leu Ala 
            20                  25                  30          

Phe Leu Phe Gln Asn His Leu Tyr Phe 
        35                  40      

<210>   4791
<211>   228
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4791
atgaatacaa aaacgatgtc acaatttgaa attatggata ctgagatgct tgcttgcgtt   60
gaaggtggcg gatgcaattg gggagatttt gccaaagcag gtgttggagg aggagcagca   120
cgaggtcttc agctaggaat taaaacaaga acatggcaag gtgcagcaac tggtgctgtg   180
ggaggagcta tacttggagg tgtggcctat gcagcgacat gttggtgg                228

<210>   4792
<211>   76
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   bacteriocin BlpU (blpU)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902084 (2.E-41)

<400>   4792
Met Asn Thr Lys Thr Met Ser Gln Phe Glu Ile Met Asp Thr Glu Met 
1               5                   10                  15      

Leu Ala Cys Val Glu Gly Gly Gly Cys Asn Trp Gly Asp Phe Ala Lys 
            20                  25                  30          

Ala Gly Val Gly Gly Gly Ala Ala Arg Gly Leu Gln Leu Gly Ile Lys 
        35                  40                  45              

Thr Arg Thr Trp Gln Gly Ala Ala Thr Gly Ala Val Gly Gly Ala Ile 
    50                  55                  60                  

Leu Gly Gly Val Ala Tyr Ala Ala Thr Cys Trp Trp 
65                  70                  75      

<210>   4793
<211>   2178
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4793
ttgagtatta gggaaaagga gatgaatatg aaatttggga aacgtcatta tcgtccgcag   60
gtggatcaga tggactgcgg tgtagcttca ttagccatgg tttttggcta ctatggtagt   120
tattattttt tggctcactt gcgagaattg gctaagacga ccatggatgg gacgacggct   180
ttgggcttgg tcaaggtggc agaggagatt ggttttgaga cgcgagccat taaggcagat   240
atgacgcttt ttgacttgcc ggatttaact tttccttttg ttgcccatgt gcttaaggaa   300
gggaaattgc tccactacta tgtggtgact gggcaggata aggatagcat tcatattgcc   360
gatccagatc ccggggtgaa gttgactaaa ctgccacgtg agcgttttga ggaagaatgg   420
acaggagtga ctctttttat ggcacctagt ccagactata agcctcataa ggaacaaaaa   480
aatggtctgc tctcttttat ccctatatta gtgaagcagc gtggcttgat tgccaatatc   540
gttttggcaa cactcttggt aaccgtgatt aacattgtgg gttcttatta tctgcagtct   600
atcattgata cctatgtgcc agatcagatg cgttcgacac tagggattat ttctattggg   660
ctagtcatcg tctacatctt ccagcaaatc ttgtcttacg ctcaggagta tctcttgctt   720
gttttggggc aacgcttgtc gattgacgtg attttgtcct atatcaagca tgtttttcac   780
ctccctatgt ccttctttgc gacacgcagg acaggggaga tcgtgtctcg ttttacagat   840
gctaacagta tcatcgatgc gctggcttcg accatccttt cgattttcct agatgtgtca   900
acggttgtca ttatttccct tgttctattt tcacaaaata ccaatctctt tttcatgact   960
ttattggcgc ttcctatcta cacagtgatt atctttgcct ttatgaagcc gtttgaaaag   1020
atgaatcggg ataccatgga agccaatgcg gttctgtctt cttctatcat tgaggacatc   1080
aacggtattg agactatcaa gtccttgacc agtgaaagtc agcgttacca aaaaattgac   1140
aaggaatttg tggattatct gaagaaatcc tttacctata gtcgagcaga gagtcagcaa   1200
aaggctctga aaaaggttgc ccatctcttg cttaatgtcg gcattctctg gatgggggct   1260
gttctggtca tggatggcaa gatgagtttg gggcagttga ttacctataa taccttgctg   1320
gtttacttta ctaatccttt ggaaaatatc atcaatctgc aaaccaagct tcagacagcg   1380
caggttgcca ataaccgtct aaatgaagtg tatctagtag cttctgagtt tgaggagaag   1440
aaaacagttg aggatttgag cttgatgaag ggagatatga ccttcaagca ggttcattac   1500
aagtatggct atggtcgaga tgtcttatcg gatatcaatt taaccgttcc ccaagggtct   1560
aaggtggctt ttgtggggat ttcagggtca ggtaagacga ctttggccaa gatgatggtt   1620
aatttttacg acccaagtca aggggagatt agtctgggta gtgtcaatct caatcagatt   1680
gataaaaaag ccctgcgcca gtacatcaac tatctgtctc aacagcccta tgtctttaac   1740
ggaacgattt tggagaatct tcttttggga gccaaggagg ggacgacaca ggaagatatc   1800
ttacgggcgg tcgaattggc agagattcga gaggatatcg agcgcatgcc actgaattac   1860
cagacagaat tgacttcgga tggggcaggg atttcaggtg gtcaacgtca gagaatcgct   1920
ttggcgcgtg ctctcttgac agatgcgccg gtcttgattt tggatgaggc gactagcagt   1980
ttggatattt tgacagagaa gcggattgtc gataatctca ttgctttgga caagaccttg   2040
attttcattg ctcaccgctt gactattgct gagcggacag agaaggtagt tgtcttggat   2100
cagggcaaga ttgtcgaaga aggaaagcat gctgatttgc ttgcacaggg tggcttttac   2160
gcccatttgg tcaatagc                                                 2178

<210>   4794
<211>   726
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence factor transporting ATP-binding/permease protein ComA (comA)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902087 (0.E+01)

<400>   4794
Met Ser Ile Arg Glu Lys Glu Met Asn Met Lys Phe Gly Lys Arg His 
1               5                   10                  15      

Tyr Arg Pro Gln Val Asp Gln Met Asp Cys Gly Val Ala Ser Leu Ala 
            20                  25                  30          

Met Val Phe Gly Tyr Tyr Gly Ser Tyr Tyr Phe Leu Ala His Leu Arg 
        35                  40                  45              

Glu Leu Ala Lys Thr Thr Met Asp Gly Thr Thr Ala Leu Gly Leu Val 
    50                  55                  60                  

Lys Val Ala Glu Glu Ile Gly Phe Glu Thr Arg Ala Ile Lys Ala Asp 
65                  70                  75                  80  

Met Thr Leu Phe Asp Leu Pro Asp Leu Thr Phe Pro Phe Val Ala His 
                85                  90                  95      

Val Leu Lys Glu Gly Lys Leu Leu His Tyr Tyr Val Val Thr Gly Gln 
            100                 105                 110         

Asp Lys Asp Ser Ile His Ile Ala Asp Pro Asp Pro Gly Val Lys Leu 
        115                 120                 125             

Thr Lys Leu Pro Arg Glu Arg Phe Glu Glu Glu Trp Thr Gly Val Thr 
    130                 135                 140                 

Leu Phe Met Ala Pro Ser Pro Asp Tyr Lys Pro His Lys Glu Gln Lys 
145                 150                 155                 160 

Asn Gly Leu Leu Ser Phe Ile Pro Ile Leu Val Lys Gln Arg Gly Leu 
                165                 170                 175     

Ile Ala Asn Ile Val Leu Ala Thr Leu Leu Val Thr Val Ile Asn Ile 
            180                 185                 190         

Val Gly Ser Tyr Tyr Leu Gln Ser Ile Ile Asp Thr Tyr Val Pro Asp 
        195                 200                 205             

Gln Met Arg Ser Thr Leu Gly Ile Ile Ser Ile Gly Leu Val Ile Val 
    210                 215                 220                 

Tyr Ile Phe Gln Gln Ile Leu Ser Tyr Ala Gln Glu Tyr Leu Leu Leu 
225                 230                 235                 240 

Val Leu Gly Gln Arg Leu Ser Ile Asp Val Ile Leu Ser Tyr Ile Lys 
                245                 250                 255     

His Val Phe His Leu Pro Met Ser Phe Phe Ala Thr Arg Arg Thr Gly 
            260                 265                 270         

Glu Ile Val Ser Arg Phe Thr Asp Ala Asn Ser Ile Ile Asp Ala Leu 
        275                 280                 285             

Ala Ser Thr Ile Leu Ser Ile Phe Leu Asp Val Ser Thr Val Val Ile 
    290                 295                 300                 

Ile Ser Leu Val Leu Phe Ser Gln Asn Thr Asn Leu Phe Phe Met Thr 
305                 310                 315                 320 

Leu Leu Ala Leu Pro Ile Tyr Thr Val Ile Ile Phe Ala Phe Met Lys 
                325                 330                 335     

Pro Phe Glu Lys Met Asn Arg Asp Thr Met Glu Ala Asn Ala Val Leu 
            340                 345                 350         

Ser Ser Ser Ile Ile Glu Asp Ile Asn Gly Ile Glu Thr Ile Lys Ser 
        355                 360                 365             

Leu Thr Ser Glu Ser Gln Arg Tyr Gln Lys Ile Asp Lys Glu Phe Val 
    370                 375                 380                 

Asp Tyr Leu Lys Lys Ser Phe Thr Tyr Ser Arg Ala Glu Ser Gln Gln 
385                 390                 395                 400 

Lys Ala Leu Lys Lys Val Ala His Leu Leu Leu Asn Val Gly Ile Leu 
                405                 410                 415     

Trp Met Gly Ala Val Leu Val Met Asp Gly Lys Met Ser Leu Gly Gln 
            420                 425                 430         

Leu Ile Thr Tyr Asn Thr Leu Leu Val Tyr Phe Thr Asn Pro Leu Glu 
        435                 440                 445             

Asn Ile Ile Asn Leu Gln Thr Lys Leu Gln Thr Ala Gln Val Ala Asn 
    450                 455                 460                 

Asn Arg Leu Asn Glu Val Tyr Leu Val Ala Ser Glu Phe Glu Glu Lys 
465                 470                 475                 480 

Lys Thr Val Glu Asp Leu Ser Leu Met Lys Gly Asp Met Thr Phe Lys 
                485                 490                 495     

Gln Val His Tyr Lys Tyr Gly Tyr Gly Arg Asp Val Leu Ser Asp Ile 
            500                 505                 510         

Asn Leu Thr Val Pro Gln Gly Ser Lys Val Ala Phe Val Gly Ile Ser 
        515                 520                 525             

Gly Ser Gly Lys Thr Thr Leu Ala Lys Met Met Val Asn Phe Tyr Asp 
    530                 535                 540                 

Pro Ser Gln Gly Glu Ile Ser Leu Gly Ser Val Asn Leu Asn Gln Ile 
545                 550                 555                 560 

Asp Lys Lys Ala Leu Arg Gln Tyr Ile Asn Tyr Leu Ser Gln Gln Pro 
                565                 570                 575     

Tyr Val Phe Asn Gly Thr Ile Leu Glu Asn Leu Leu Leu Gly Ala Lys 
            580                 585                 590         

Glu Gly Thr Thr Gln Glu Asp Ile Leu Arg Ala Val Glu Leu Ala Glu 
        595                 600                 605             

Ile Arg Glu Asp Ile Glu Arg Met Pro Leu Asn Tyr Gln Thr Glu Leu 
    610                 615                 620                 

Thr Ser Asp Gly Ala Gly Ile Ser Gly Gly Gln Arg Gln Arg Ile Ala 
625                 630                 635                 640 

Leu Ala Arg Ala Leu Leu Thr Asp Ala Pro Val Leu Ile Leu Asp Glu 
                645                 650                 655     

Ala Thr Ser Ser Leu Asp Ile Leu Thr Glu Lys Arg Ile Val Asp Asn 
            660                 665                 670         

Leu Ile Ala Leu Asp Lys Thr Leu Ile Phe Ile Ala His Arg Leu Thr 
        675                 680                 685             

Ile Ala Glu Arg Thr Glu Lys Val Val Val Leu Asp Gln Gly Lys Ile 
    690                 695                 700                 

Val Glu Glu Gly Lys His Ala Asp Leu Leu Ala Gln Gly Gly Phe Tyr 
705                 710                 715                 720 

Ala His Leu Val Asn Ser 
                725     

<210>   4795
<211>   1347
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4795
atgaaaccag aatttttaga aagtgcggag ttttataatc gtcgttacca taatttttcc   60
agtagtgtga ttgtacccat ggcccttctg cttgtgtttt tacttggctt tgcaactgtt   120
gcagagaagg agatgagttt gtccactaga gctactgtcg aacctagtcg tatccttgca   180
aatatccagt caactagcaa caatcgtatt cttgtcaatc atttggaaga aaataagctg   240
gttaagaagg gggatctttt ggttcaatac caagaagggg cagagggtgt ccaagcggag   300
tcctatgcca gtcagttgga catgctaaag gatcaaaaaa agcaattgga gtatctgcaa   360
aagagcctgc aagaagggga gaaccacttt ccagaggagg ataagtttgg ctaccaagcc   420
acctttcgcg actacatcag tcaagcaggc agtcttaggg ctagtacatc gcaacaaaat   480
gagaccatcg cgtcccagaa tgcagcagct agccaaaccc aagccgaaat cggcaacctc   540
atcagtcaaa cagaggctaa aattcgcgat taccagacag ctaagtcagc tattgaaaca   600
ggtgcttcct tggccggtca gaatctagcc tactctcttt accagtccta caagtctcag   660
ggcgaggaaa atccccaaac taaggttcag gcagttgcac aggttgaagc acagatttct   720
cagttagaat ctagtcttgc tacttaccgt gtccagtatg caggttcagg tacccagcaa   780
gcctatgcgt cagggttaag cagtcaattg gaatccctta aatcccaaca cttggcaaag   840
gttggtcagg aattgaccct tctagcccag aaaattttgg aggcagagtc aggtaagaag   900
gtacagggaa atcttttaga caaggggaaa gttacggcga gtgaggatgg ggtgcttcat   960
cttaatcctg agaccagtga ttctagcatg gttgcagaag gtgccctact agcccaactt   1020
tatccatctt tggaaagaga agggaaagcc aaactcacag cttatctaag ttcaaaatat   1080
gtagcaagaa tcaaggtcgg tgattctgtt cgctatacta cgactcatga tgccgggaat   1140
caacttttcc tagattctac tattacaagt attgatgcga cagctactaa gactgagaaa   1200
gggaatttct ttaaaatcga ggcggagact aatctaactt cggagcaggc tgaaaaactt   1260
aggtacgggg tggaaggccg cttgcagatg attacgggca agaaaagtta cctacgttat   1320
tatttggatc aatttttgaa caaagag                                       1347

<210>   4796
<211>   449
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence factor transport protein ComB (comB)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902088 (0.E+01)

<400>   4796
Met Lys Pro Glu Phe Leu Glu Ser Ala Glu Phe Tyr Asn Arg Arg Tyr 
1               5                   10                  15      

His Asn Phe Ser Ser Ser Val Ile Val Pro Met Ala Leu Leu Leu Val 
            20                  25                  30          

Phe Leu Leu Gly Phe Ala Thr Val Ala Glu Lys Glu Met Ser Leu Ser 
        35                  40                  45              

Thr Arg Ala Thr Val Glu Pro Ser Arg Ile Leu Ala Asn Ile Gln Ser 
    50                  55                  60                  

Thr Ser Asn Asn Arg Ile Leu Val Asn His Leu Glu Glu Asn Lys Leu 
65                  70                  75                  80  

Val Lys Lys Gly Asp Leu Leu Val Gln Tyr Gln Glu Gly Ala Glu Gly 
                85                  90                  95      

Val Gln Ala Glu Ser Tyr Ala Ser Gln Leu Asp Met Leu Lys Asp Gln 
            100                 105                 110         

Lys Lys Gln Leu Glu Tyr Leu Gln Lys Ser Leu Gln Glu Gly Glu Asn 
        115                 120                 125             

His Phe Pro Glu Glu Asp Lys Phe Gly Tyr Gln Ala Thr Phe Arg Asp 
    130                 135                 140                 

Tyr Ile Ser Gln Ala Gly Ser Leu Arg Ala Ser Thr Ser Gln Gln Asn 
145                 150                 155                 160 

Glu Thr Ile Ala Ser Gln Asn Ala Ala Ala Ser Gln Thr Gln Ala Glu 
                165                 170                 175     

Ile Gly Asn Leu Ile Ser Gln Thr Glu Ala Lys Ile Arg Asp Tyr Gln 
            180                 185                 190         

Thr Ala Lys Ser Ala Ile Glu Thr Gly Ala Ser Leu Ala Gly Gln Asn 
        195                 200                 205             

Leu Ala Tyr Ser Leu Tyr Gln Ser Tyr Lys Ser Gln Gly Glu Glu Asn 
    210                 215                 220                 

Pro Gln Thr Lys Val Gln Ala Val Ala Gln Val Glu Ala Gln Ile Ser 
225                 230                 235                 240 

Gln Leu Glu Ser Ser Leu Ala Thr Tyr Arg Val Gln Tyr Ala Gly Ser 
                245                 250                 255     

Gly Thr Gln Gln Ala Tyr Ala Ser Gly Leu Ser Ser Gln Leu Glu Ser 
            260                 265                 270         

Leu Lys Ser Gln His Leu Ala Lys Val Gly Gln Glu Leu Thr Leu Leu 
        275                 280                 285             

Ala Gln Lys Ile Leu Glu Ala Glu Ser Gly Lys Lys Val Gln Gly Asn 
    290                 295                 300                 

Leu Leu Asp Lys Gly Lys Val Thr Ala Ser Glu Asp Gly Val Leu His 
305                 310                 315                 320 

Leu Asn Pro Glu Thr Ser Asp Ser Ser Met Val Ala Glu Gly Ala Leu 
                325                 330                 335     

Leu Ala Gln Leu Tyr Pro Ser Leu Glu Arg Glu Gly Lys Ala Lys Leu 
            340                 345                 350         

Thr Ala Tyr Leu Ser Ser Lys Tyr Val Ala Arg Ile Lys Val Gly Asp 
        355                 360                 365             

Ser Val Arg Tyr Thr Thr Thr His Asp Ala Gly Asn Gln Leu Phe Leu 
    370                 375                 380                 

Asp Ser Thr Ile Thr Ser Ile Asp Ala Thr Ala Thr Lys Thr Glu Lys 
385                 390                 395                 400 

Gly Asn Phe Phe Lys Ile Glu Ala Glu Thr Asn Leu Thr Ser Glu Gln 
                405                 410                 415     

Ala Glu Lys Leu Arg Tyr Gly Val Glu Gly Arg Leu Gln Met Ile Thr 
            420                 425                 430         

Gly Lys Lys Ser Tyr Leu Arg Tyr Tyr Leu Asp Gln Phe Leu Asn Lys 
        435                 440                 445             

Glu 
    

<210>   4797
<211>   747
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4797
gtggtaaaat gtgctcaagt aatacgaaag gcgaacttta aaatgtcaaa acaattgatc   60
tattcgggaa aagctaaaga tatctataca actgaggatg aaaatcttat tatttcaact   120
tacaaggacc aggcgactgc tttcaacggt gtcaagaagg agcagattgc aggtaaggga   180
gtcttgaata atcagatctc atcttttatt tttgagaaat taaatgtggc tggtgtggcg   240
actcactttg tggagaaact ttcagacacg gaacaactca ataaaaaggt taagattatt   300
cctttggaag tcgtgctccg caactatact gctggttcct tttcaaaacg ttttggtgtg   360
gatgagggaa tcgccttgga gactccgatt gtcgaatttt actacaaaaa tgatgatttg   420
gatgatccat ttatcaatga tgagcatgtg aaattcctac agattgcggg tgaccagcag   480
attgcctact tgaaggaaga aacgcgtcgt atcaatgaac tattgaaagt ctggtttgct   540
gagattgggc ttaaattgat tgactttaag ctagagttcg gttttgacaa ggatggcaag   600
attatcttgg cagacgaatt ttcaccagat aactgccgct tgtgggacgc tgatggcaac   660
cacatggata aggatgtttt ccgtagagga ttgggagaac taaccgacgt ttatgagatt   720
gtttgggaaa agttgcagga attgaaa                                       747

<210>   4798
<211>   249
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902089 (e-133)

<400>   4798
Met Val Lys Cys Ala Gln Val Ile Arg Lys Ala Asn Phe Lys Met Ser 
1               5                   10                  15      

Lys Gln Leu Ile Tyr Ser Gly Lys Ala Lys Asp Ile Tyr Thr Thr Glu 
            20                  25                  30          

Asp Glu Asn Leu Ile Ile Ser Thr Tyr Lys Asp Gln Ala Thr Ala Phe 
        35                  40                  45              

Asn Gly Val Lys Lys Glu Gln Ile Ala Gly Lys Gly Val Leu Asn Asn 
    50                  55                  60                  

Gln Ile Ser Ser Phe Ile Phe Glu Lys Leu Asn Val Ala Gly Val Ala 
65                  70                  75                  80  

Thr His Phe Val Glu Lys Leu Ser Asp Thr Glu Gln Leu Asn Lys Lys 
                85                  90                  95      

Val Lys Ile Ile Pro Leu Glu Val Val Leu Arg Asn Tyr Thr Ala Gly 
            100                 105                 110         

Ser Phe Ser Lys Arg Phe Gly Val Asp Glu Gly Ile Ala Leu Glu Thr 
        115                 120                 125             

Pro Ile Val Glu Phe Tyr Tyr Lys Asn Asp Asp Leu Asp Asp Pro Phe 
    130                 135                 140                 

Ile Asn Asp Glu His Val Lys Phe Leu Gln Ile Ala Gly Asp Gln Gln 
145                 150                 155                 160 

Ile Ala Tyr Leu Lys Glu Glu Thr Arg Arg Ile Asn Glu Leu Leu Lys 
                165                 170                 175     

Val Trp Phe Ala Glu Ile Gly Leu Lys Leu Ile Asp Phe Lys Leu Glu 
            180                 185                 190         

Phe Gly Phe Asp Lys Asp Gly Lys Ile Ile Leu Ala Asp Glu Phe Ser 
        195                 200                 205             

Pro Asp Asn Cys Arg Leu Trp Asp Ala Asp Gly Asn His Met Asp Lys 
    210                 215                 220                 

Asp Val Phe Arg Arg Gly Leu Gly Glu Leu Thr Asp Val Tyr Glu Ile 
225                 230                 235                 240 

Val Trp Glu Lys Leu Gln Glu Leu Lys 
                245                 

<210>   4799
<211>   3726
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4799
ttgatggata aacgtatttt tgttgaaaaa aaggctgatt ttcaggtcaa gtcagagagt   60
ttggttagag agctccagca caacttggga ctgtcaagct tgaaaagtat tcgtattgtg   120
caagtatatg atgtatttga cttggctgag gacttgtttg cacctgcaga gaagcacatt   180
ttctctgagc aggtaaccga ccatgtttta gatgaagtat ctgtgcaggc ggatcttgct   240
aactatgctt tctttgccat tgaaagtctg ccagggcagt ttgaccagcg tgcagcttcg   300
tcacaggaag ccttgctttt gttgggaagt tcgagtgacg tgacagtcaa cacagcccaa   360
ctttacttgg tgaataaaga tattgatgcg actgagttgg aagctgtcaa aaactacctg   420
ctcaatccag ttgattctcg tttcaaggat atcacgacag ggattgccaa gcaggagttt   480
tcagagtcag acaagaccat tcccaaattg actttctttg aaagctatgc agcagaagac   540
tttgctcgct acaaggccga acaagggatg gccatggaag tggatgattt gctctttatc   600
caagactact ttaagtcaat cgggcgcgtg ccaactgaga ctgaactcaa ggttttggac   660
acttactggt ctgaccactg ccgtcatacg acttttgaga cagagttgaa acacatcgac   720
ttttcagctt ctaaatttca aaagcaattg cagtcaacct atgacaagta tattgccatg   780
cgcgaggaat taggtcggtc tgaaaaacca caaaccttga tggatatggc gactattttc   840
ggtcgttatg agcgtgctaa tggacgattg gatgatatgg aagtctctga cgaaatcaat   900
gcctgctcag ttgaaattga agtggacgtt gatggtgtca aggaaccttg gctcctcatg   960
tttaaaaacg aaacccacaa ccatccaaca gaaattgagc catttggtgg agcggctacc   1020
tgtattggtg gagctattcg tgatccgttg tcaggccgtt cctatgttta ccaagccatg   1080
cgtatttcag gtgctggtga tattacagca ccgatttcgg aaactcgcgc tgggaaattg   1140
ccacaacaag tcatttctaa aacagcagct catggttatt cttcatatgg taaccagatt   1200
gggcttgcaa caacctacgt tcgtgaatac ttccacccag gctttgtagc taaacgtatg   1260
gaacttggtg ccgttgttgg tgcgactccc aagggcaatg ttgtccgtga aaaacctgaa   1320
gcaggtgatg tgatcatcct tctcggaggc aaaacaggtc gtgatggtgt cggtggtgcg   1380
acgggctctt ctaaggttca aacagttgag tctgtagaga ctgctggtgc tgaggttcaa   1440
aaaggaaatg ccatcgaaga acgcaagatt cagcgcctct tccgtaatgg caatgtcact   1500
cgtctgatca agaagtccaa tgactttggg gcaggcggtg tctgtgtggc tatcggtgaa   1560
ttggcagacg gtcttgaaat cgacctcaac aaggtgcctc ttaaatacca gggcttgaat   1620
ggtacagaaa ttgccatctc tgaatcacaa gaacggatgg cggtcgtggt tcgtcctgaa   1680
gatgtggatg ccttcgttgc cgaatgtaac aaagaaaata ttgatgctgt tgtggtggcg   1740
acagtaactg aaaaaccaaa tcttgtcatg cactggaatg gtgagacaat cgttgacttg   1800
gagcgtcgtt tccttgacac caatggtgtg cgcgtggttg tcgatgccaa agttgtggac   1860
aaggatgtca aactcccaga agagcgtcaa acatctgctg aaacactgga atcagatacc   1920
cttacggttc tatctgacct caaccatgca agtcaaaaag gattacagac tatctttgac   1980
tgctctgttg gacgctcaac ggttaatcac ccacttggtg gtcgttacca actcacacca   2040
actgaggcat ctgtgcagaa attgccagtt caacacggtg tgactcatac tgcgtcggtc   2100
attgctcaag gtttcaaccc atatgtagct gaatggtctc cataccacgg tgctgcttat   2160
gcggttatcg aagcaactgc tcgtttggtg gctgctggtg ccaactggtt caaggctcgt   2220
ttctcttacc aagagtattt cgagcgtatg gataaacaag cagagcgttt cggtcagcca   2280
gtagctgctc ttctaggttc tattgaagca caaattcagc ttggcttgcc atctatcggt   2340
ggtaaggact ccatgtctgg tacctttgaa gaattgaccg ttccgccaac cttggctgcc   2400
tttggggtga cgacggcaga tagccgtaag gtgctctctc cagaatttaa agctgttggg   2460
gaaaatatct actacatccc aggtcaagcc ctctctgcag agattgattt tgacttgatt   2520
aagaaaaatt ttgctcagtt tgaagccatc caagctgacc ataaagtgac atctgcatca   2580
gctgtcaaat acggtggtgt agttgaaagt ttggctcttg ctacctttgg aaactatatt   2640
ggtgcagagg tgaccttgcc tgaacttgaa acagctttga cagctcaatt aggcggcttt   2700
gtcttcacat ctcctgaaga aattgctgga gtagagaagg ttggacaaac gaaagcagac   2760
tttacactga ctgtcaacgg tgtgaagcta gatggacaca agcttgacag tgcatttcaa   2820
gggacattgg aagaagttta cccaacagaa tttacccaag cgaaagaact agaagaagta   2880
ccagctgtgg catcagatgt tgtgattaaa gccaaagaaa aggttgaaaa acctgtggtt   2940
tacatcccag tctttccagg aaccaactca gaatatgatt cagctaaggc cttcgaaaaa   3000
gaaggtgcag aggtcaattt ggtgccattc gtgaccttga atgaagaagc tattgtcaag   3060
tcagttgaaa ctatggttga caatatcgac aagactaata ttctcttctt tgctggtgga   3120
ttctcggctg cggatgaacc agatggttca gctaagttta tcgtcaatat cctgcttaat   3180
gaaaaagtgc gtgtggctat tgatagcttt atcgcccgtg gtggtttgat tatcggtatt   3240
tgtaatggat tccaagcctt agtcaaatcg ggtctcctac cctacggaaa ctttgaagct   3300
gctaacagta ctagcccaac cctcttctac aatgatgcca accaacacgt ggccaagatg   3360
gtggaaactc gcattgccaa taccaactca ccatggttgg ttggtgtgca agtgggcgat   3420
atccacgcta ttcctgtttc gcacggtgaa gggaagtttg tcgtgacggc tgaggaattt   3480
gcagagctcc gtgacaatgg acaaattttc agccaatacg ttgactttaa cggtaaacca   3540
agtatggatt ctaagtacaa tccgaatggt tctgtccatg ccatcgaagg aattaccagc   3600
aagaatggtc aaatcatcgg taagatgggc cactcagaac gttatgagga tggtcttttc   3660
caaaatatcc caggcaataa agaccaacac ctgttcgcat cagcggttaa acatttcact   3720
ggaaaa                                                              3726

<210>   4800
<211>   1242
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoribosylformylglycinamidine synthase, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902090 (0.E+01)

<400>   4800
Met Met Asp Lys Arg Ile Phe Val Glu Lys Lys Ala Asp Phe Gln Val 
1               5                   10                  15      

Lys Ser Glu Ser Leu Val Arg Glu Leu Gln His Asn Leu Gly Leu Ser 
            20                  25                  30          

Ser Leu Lys Ser Ile Arg Ile Val Gln Val Tyr Asp Val Phe Asp Leu 
        35                  40                  45              

Ala Glu Asp Leu Phe Ala Pro Ala Glu Lys His Ile Phe Ser Glu Gln 
    50                  55                  60                  

Val Thr Asp His Val Leu Asp Glu Val Ser Val Gln Ala Asp Leu Ala 
65                  70                  75                  80  

Asn Tyr Ala Phe Phe Ala Ile Glu Ser Leu Pro Gly Gln Phe Asp Gln 
                85                  90                  95      

Arg Ala Ala Ser Ser Gln Glu Ala Leu Leu Leu Leu Gly Ser Ser Ser 
            100                 105                 110         

Asp Val Thr Val Asn Thr Ala Gln Leu Tyr Leu Val Asn Lys Asp Ile 
        115                 120                 125             

Asp Ala Thr Glu Leu Glu Ala Val Lys Asn Tyr Leu Leu Asn Pro Val 
    130                 135                 140                 

Asp Ser Arg Phe Lys Asp Ile Thr Thr Gly Ile Ala Lys Gln Glu Phe 
145                 150                 155                 160 

Ser Glu Ser Asp Lys Thr Ile Pro Lys Leu Thr Phe Phe Glu Ser Tyr 
                165                 170                 175     

Ala Ala Glu Asp Phe Ala Arg Tyr Lys Ala Glu Gln Gly Met Ala Met 
            180                 185                 190         

Glu Val Asp Asp Leu Leu Phe Ile Gln Asp Tyr Phe Lys Ser Ile Gly 
        195                 200                 205             

Arg Val Pro Thr Glu Thr Glu Leu Lys Val Leu Asp Thr Tyr Trp Ser 
    210                 215                 220                 

Asp His Cys Arg His Thr Thr Phe Glu Thr Glu Leu Lys His Ile Asp 
225                 230                 235                 240 

Phe Ser Ala Ser Lys Phe Gln Lys Gln Leu Gln Ser Thr Tyr Asp Lys 
                245                 250                 255     

Tyr Ile Ala Met Arg Glu Glu Leu Gly Arg Ser Glu Lys Pro Gln Thr 
            260                 265                 270         

Leu Met Asp Met Ala Thr Ile Phe Gly Arg Tyr Glu Arg Ala Asn Gly 
        275                 280                 285             

Arg Leu Asp Asp Met Glu Val Ser Asp Glu Ile Asn Ala Cys Ser Val 
    290                 295                 300                 

Glu Ile Glu Val Asp Val Asp Gly Val Lys Glu Pro Trp Leu Leu Met 
305                 310                 315                 320 

Phe Lys Asn Glu Thr His Asn His Pro Thr Glu Ile Glu Pro Phe Gly 
                325                 330                 335     

Gly Ala Ala Thr Cys Ile Gly Gly Ala Ile Arg Asp Pro Leu Ser Gly 
            340                 345                 350         

Arg Ser Tyr Val Tyr Gln Ala Met Arg Ile Ser Gly Ala Gly Asp Ile 
        355                 360                 365             

Thr Ala Pro Ile Ser Glu Thr Arg Ala Gly Lys Leu Pro Gln Gln Val 
    370                 375                 380                 

Ile Ser Lys Thr Ala Ala His Gly Tyr Ser Ser Tyr Gly Asn Gln Ile 
385                 390                 395                 400 

Gly Leu Ala Thr Thr Tyr Val Arg Glu Tyr Phe His Pro Gly Phe Val 
                405                 410                 415     

Ala Lys Arg Met Glu Leu Gly Ala Val Val Gly Ala Thr Pro Lys Gly 
            420                 425                 430         

Asn Val Val Arg Glu Lys Pro Glu Ala Gly Asp Val Ile Ile Leu Leu 
        435                 440                 445             

Gly Gly Lys Thr Gly Arg Asp Gly Val Gly Gly Ala Thr Gly Ser Ser 
    450                 455                 460                 

Lys Val Gln Thr Val Glu Ser Val Glu Thr Ala Gly Ala Glu Val Gln 
465                 470                 475                 480 

Lys Gly Asn Ala Ile Glu Glu Arg Lys Ile Gln Arg Leu Phe Arg Asn 
                485                 490                 495     

Gly Asn Val Thr Arg Leu Ile Lys Lys Ser Asn Asp Phe Gly Ala Gly 
            500                 505                 510         

Gly Val Cys Val Ala Ile Gly Glu Leu Ala Asp Gly Leu Glu Ile Asp 
        515                 520                 525             

Leu Asn Lys Val Pro Leu Lys Tyr Gln Gly Leu Asn Gly Thr Glu Ile 
    530                 535                 540                 

Ala Ile Ser Glu Ser Gln Glu Arg Met Ala Val Val Val Arg Pro Glu 
545                 550                 555                 560 

Asp Val Asp Ala Phe Val Ala Glu Cys Asn Lys Glu Asn Ile Asp Ala 
                565                 570                 575     

Val Val Val Ala Thr Val Thr Glu Lys Pro Asn Leu Val Met His Trp 
            580                 585                 590         

Asn Gly Glu Thr Ile Val Asp Leu Glu Arg Arg Phe Leu Asp Thr Asn 
        595                 600                 605             

Gly Val Arg Val Val Val Asp Ala Lys Val Val Asp Lys Asp Val Lys 
    610                 615                 620                 

Leu Pro Glu Glu Arg Gln Thr Ser Ala Glu Thr Leu Glu Ser Asp Thr 
625                 630                 635                 640 

Leu Thr Val Leu Ser Asp Leu Asn His Ala Ser Gln Lys Gly Leu Gln 
                645                 650                 655     

Thr Ile Phe Asp Cys Ser Val Gly Arg Ser Thr Val Asn His Pro Leu 
            660                 665                 670         

Gly Gly Arg Tyr Gln Leu Thr Pro Thr Glu Ala Ser Val Gln Lys Leu 
        675                 680                 685             

Pro Val Gln His Gly Val Thr His Thr Ala Ser Val Ile Ala Gln Gly 
    690                 695                 700                 

Phe Asn Pro Tyr Val Ala Glu Trp Ser Pro Tyr His Gly Ala Ala Tyr 
705                 710                 715                 720 

Ala Val Ile Glu Ala Thr Ala Arg Leu Val Ala Ala Gly Ala Asn Trp 
                725                 730                 735     

Phe Lys Ala Arg Phe Ser Tyr Gln Glu Tyr Phe Glu Arg Met Asp Lys 
            740                 745                 750         

Gln Ala Glu Arg Phe Gly Gln Pro Val Ala Ala Leu Leu Gly Ser Ile 
        755                 760                 765             

Glu Ala Gln Ile Gln Leu Gly Leu Pro Ser Ile Gly Gly Lys Asp Ser 
    770                 775                 780                 

Met Ser Gly Thr Phe Glu Glu Leu Thr Val Pro Pro Thr Leu Ala Ala 
785                 790                 795                 800 

Phe Gly Val Thr Thr Ala Asp Ser Arg Lys Val Leu Ser Pro Glu Phe 
                805                 810                 815     

Lys Ala Val Gly Glu Asn Ile Tyr Tyr Ile Pro Gly Gln Ala Leu Ser 
            820                 825                 830         

Ala Glu Ile Asp Phe Asp Leu Ile Lys Lys Asn Phe Ala Gln Phe Glu 
        835                 840                 845             

Ala Ile Gln Ala Asp His Lys Val Thr Ser Ala Ser Ala Val Lys Tyr 
    850                 855                 860                 

Gly Gly Val Val Glu Ser Leu Ala Leu Ala Thr Phe Gly Asn Tyr Ile 
865                 870                 875                 880 

Gly Ala Glu Val Thr Leu Pro Glu Leu Glu Thr Ala Leu Thr Ala Gln 
                885                 890                 895     

Leu Gly Gly Phe Val Phe Thr Ser Pro Glu Glu Ile Ala Gly Val Glu 
            900                 905                 910         

Lys Val Gly Gln Thr Lys Ala Asp Phe Thr Leu Thr Val Asn Gly Val 
        915                 920                 925             

Lys Leu Asp Gly His Lys Leu Asp Ser Ala Phe Gln Gly Thr Leu Glu 
    930                 935                 940                 

Glu Val Tyr Pro Thr Glu Phe Thr Gln Ala Lys Glu Leu Glu Glu Val 
945                 950                 955                 960 

Pro Ala Val Ala Ser Asp Val Val Ile Lys Ala Lys Glu Lys Val Glu 
                965                 970                 975     

Lys Pro Val Val Tyr Ile Pro Val Phe Pro Gly Thr Asn Ser Glu Tyr 
            980                 985                 990         

Asp Ser Ala Lys Ala Phe Glu Lys Glu Gly Ala Glu Val Asn Leu Val 
        995                 1000                1005            

Pro Phe Val Thr Leu Asn Glu Glu Ala Ile Val Lys Ser Val Glu Thr 
    1010                1015                1020                

Met Val Asp Asn Ile Asp Lys Thr Asn Ile Leu Phe Phe Ala Gly Gly 
1025                1030                1035                1040

Phe Ser Ala Ala Asp Glu Pro Asp Gly Ser Ala Lys Phe Ile Val Asn 
                1045                1050                1055    

Ile Leu Leu Asn Glu Lys Val Arg Val Ala Ile Asp Ser Phe Ile Ala 
            1060                1065                1070        

Arg Gly Gly Leu Ile Ile Gly Ile Cys Asn Gly Phe Gln Ala Leu Val 
        1075                1080                1085            

Lys Ser Gly Leu Leu Pro Tyr Gly Asn Phe Glu Ala Ala Asn Ser Thr 
    1090                1095                1100                

Ser Pro Thr Leu Phe Tyr Asn Asp Ala Asn Gln His Val Ala Lys Met 
1105                1110                1115                1120

Val Glu Thr Arg Ile Ala Asn Thr Asn Ser Pro Trp Leu Val Gly Val 
                1125                1130                1135    

Gln Val Gly Asp Ile His Ala Ile Pro Val Ser His Gly Glu Gly Lys 
            1140                1145                1150        

Phe Val Val Thr Ala Glu Glu Phe Ala Glu Leu Arg Asp Asn Gly Gln 
        1155                1160                1165            

Ile Phe Ser Gln Tyr Val Asp Phe Asn Gly Lys Pro Ser Met Asp Ser 
    1170                1175                1180                

Lys Tyr Asn Pro Asn Gly Ser Val His Ala Ile Glu Gly Ile Thr Ser 
1185                1190                1195                1200

Lys Asn Gly Gln Ile Ile Gly Lys Met Gly His Ser Glu Arg Tyr Glu 
                1205                1210                1215    

Asp Gly Leu Phe Gln Asn Ile Pro Gly Asn Lys Asp Gln His Leu Phe 
            1220                1225                1230        

Ala Ser Ala Val Lys His Phe Thr Gly Lys 
        1235                1240        

<210>   4801
<211>   1440
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4801
atgacatacg aagtaaaatc tcttaatgaa gaatgtggtg ttttcggtat ttggggacat   60
ccagatgctg ctaagttgac ctattttgga ctccacagtc ttcaacaccg tggtcaggag   120
ggggcaggaa tcctctccaa tgatcaagga caactgaagc gccatcgtga catggggctt   180
ttatcagaag ttttcagaaa tccagctaat ttggataaat tgacaggagc tggtgcgatt   240
gggcatgtgc gttatgcgac tgctggcgaa gcttctgtag ataacatcca gcccttcctc   300
ttccgttttc acgatatgca gtttggtttg gctcataatg gaaatctgac caatgcagcc   360
tctctcaaga aagaactgga acaaagagga gcaattttca gcgcgacttc ggactctgaa   420
atcttggctc acctcattcg tcgcagtcat aatcctagcc tgatgggcaa aatcaaggaa   480
gcgctcagcc ttgtcaaagg tggttttgcc tatatcttgc tgtttgagga caagttgatt   540
gcggctcttg acccaaatgg attccgaccg ctttcgattg gtaaaatggc taatggagca   600
gttgttgtat cttctgaaac ctgtgctttt gaggtcattg gtgccgagtg gattcgtgat   660
ttgaagccag gtgagattgt gatcattgat gacgagggca ttcagtatga cagctataca   720
gatgataccc agttggcggt ttgttctatg gagtatatct actttgctcg ccctgattct   780
aatatccacg gtgtcaatgt ccatacggca cgtaagagaa tgggagcgca attggcgcga   840
gaatttaagc atgaggcaga tattgtagtt ggtgtgccca attcttccct aagcgcggct   900
atgggatttg cggaagaatc aggcttacca aatgaaatgg gtctgatcaa aaaccaatac   960
acccagcgaa cttttatcca accgactcaa gaattgcggg agcaaggagt gcggatgaaa   1020
ctgtctgctg tttcgggtgt tgtcaaaggc aaacgtgtgg tcatggtgga tgattccatt   1080
gtacgtggaa caacctctcg tcgtatcgtt cagctcttga aagaagcggg tgcgactgag   1140
gttcacgttg ccattggaag tcctgcacta gcgtatccat gtttctacgg gattgatatc   1200
cagacccgtc aggagctgat tgcagccaat catacggtcg aagaaactcg ccaaatcatt   1260
ggtgcggaca gtctgactta tctttcaatt gatggcttga ttgagtcgat tggtatcgaa   1320
acagatgcgc cgaacggtgg tctctgtgtc gcttactttg acggtgacta cccaacgcct   1380
ctttatgact acgaagaaga ctatcgtaga agtttggaag aaaagaccag tttttacaag   1440

<210>   4802
<211>   480
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   amidophosphoribosyltransferase (purF)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902091 (0.E+01)

<400>   4802
Met Thr Tyr Glu Val Lys Ser Leu Asn Glu Glu Cys Gly Val Phe Gly 
1               5                   10                  15      

Ile Trp Gly His Pro Asp Ala Ala Lys Leu Thr Tyr Phe Gly Leu His 
            20                  25                  30          

Ser Leu Gln His Arg Gly Gln Glu Gly Ala Gly Ile Leu Ser Asn Asp 
        35                  40                  45              

Gln Gly Gln Leu Lys Arg His Arg Asp Met Gly Leu Leu Ser Glu Val 
    50                  55                  60                  

Phe Arg Asn Pro Ala Asn Leu Asp Lys Leu Thr Gly Ala Gly Ala Ile 
65                  70                  75                  80  

Gly His Val Arg Tyr Ala Thr Ala Gly Glu Ala Ser Val Asp Asn Ile 
                85                  90                  95      

Gln Pro Phe Leu Phe Arg Phe His Asp Met Gln Phe Gly Leu Ala His 
            100                 105                 110         

Asn Gly Asn Leu Thr Asn Ala Ala Ser Leu Lys Lys Glu Leu Glu Gln 
        115                 120                 125             

Arg Gly Ala Ile Phe Ser Ala Thr Ser Asp Ser Glu Ile Leu Ala His 
    130                 135                 140                 

Leu Ile Arg Arg Ser His Asn Pro Ser Leu Met Gly Lys Ile Lys Glu 
145                 150                 155                 160 

Ala Leu Ser Leu Val Lys Gly Gly Phe Ala Tyr Ile Leu Leu Phe Glu 
                165                 170                 175     

Asp Lys Leu Ile Ala Ala Leu Asp Pro Asn Gly Phe Arg Pro Leu Ser 
            180                 185                 190         

Ile Gly Lys Met Ala Asn Gly Ala Val Val Val Ser Ser Glu Thr Cys 
        195                 200                 205             

Ala Phe Glu Val Ile Gly Ala Glu Trp Ile Arg Asp Leu Lys Pro Gly 
    210                 215                 220                 

Glu Ile Val Ile Ile Asp Asp Glu Gly Ile Gln Tyr Asp Ser Tyr Thr 
225                 230                 235                 240 

Asp Asp Thr Gln Leu Ala Val Cys Ser Met Glu Tyr Ile Tyr Phe Ala 
                245                 250                 255     

Arg Pro Asp Ser Asn Ile His Gly Val Asn Val His Thr Ala Arg Lys 
            260                 265                 270         

Arg Met Gly Ala Gln Leu Ala Arg Glu Phe Lys His Glu Ala Asp Ile 
        275                 280                 285             

Val Val Gly Val Pro Asn Ser Ser Leu Ser Ala Ala Met Gly Phe Ala 
    290                 295                 300                 

Glu Glu Ser Gly Leu Pro Asn Glu Met Gly Leu Ile Lys Asn Gln Tyr 
305                 310                 315                 320 

Thr Gln Arg Thr Phe Ile Gln Pro Thr Gln Glu Leu Arg Glu Gln Gly 
                325                 330                 335     

Val Arg Met Lys Leu Ser Ala Val Ser Gly Val Val Lys Gly Lys Arg 
            340                 345                 350         

Val Val Met Val Asp Asp Ser Ile Val Arg Gly Thr Thr Ser Arg Arg 
        355                 360                 365             

Ile Val Gln Leu Leu Lys Glu Ala Gly Ala Thr Glu Val His Val Ala 
    370                 375                 380                 

Ile Gly Ser Pro Ala Leu Ala Tyr Pro Cys Phe Tyr Gly Ile Asp Ile 
385                 390                 395                 400 

Gln Thr Arg Gln Glu Leu Ile Ala Ala Asn His Thr Val Glu Glu Thr 
                405                 410                 415     

Arg Gln Ile Ile Gly Ala Asp Ser Leu Thr Tyr Leu Ser Ile Asp Gly 
            420                 425                 430         

Leu Ile Glu Ser Ile Gly Ile Glu Thr Asp Ala Pro Asn Gly Gly Leu 
        435                 440                 445             

Cys Val Ala Tyr Phe Asp Gly Asp Tyr Pro Thr Pro Leu Tyr Asp Tyr 
    450                 455                 460                 

Glu Glu Asp Tyr Arg Arg Ser Leu Glu Glu Lys Thr Ser Phe Tyr Lys 
465                 470                 475                 480 


<210>   4803
<211>   1077
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4803
atggtttatc taaaaatacg tcgcagtctt tctcaaaaaa agaaaaggaa aaataaaatg   60

gcaaataaaa atgcgtacgc tcaatctggt gtggatgttg aagcgggtta tgaagttgtt   120
gaacggatta aaaagcacgt ggcccgtacg gagcgtgcag gtgtcatggg agctcttggt   180
ggctttggtg gtatgtttga cctttccaag actggggtta aagaacccgt cttgatttca   240
gggactgacg gtgtcggaac caagctcatg ttggctatca agtacgacaa gcacgatacc   300
atcgggcagg actgtgtggc catgtgtgtc aacgacatca ttgctgcagg tgcggaaccc   360
ctctattttc tcgactacgt agcgacaggg aagaatgaac cagctaagct agaacaagtg   420
gttgctggtg tggcagaagg ttgtgtgcag gctggtgctg ccctcatcgg tggggaaacg   480
gctgaaatgc cgggcatgta cggcgaagac gactatgact tggctggttt tgcggtcggt   540
gtggctgaaa aatctcaaat cattgacggt tcaaaggtgg tagagggaga tgttcttctc   600
ggacttgctt caagtgggat tcactcaaat ggttactctt tggttcgtcg tgtctttgcg   660
gattacacag gtgaggaagt cctaccagaa ttggaaggca agaaacttaa ggaagttcta   720
cttgagccga ctcgtatcta tgtcaaggct gtcttgccgc tcatcaaaga agagttggtc   780
aacggcattg cccacatcac aggtggtggc tttatcgaaa atgtccctcg tatgtttgca   840
gatgacctag ctgctgaaat tgatgaaagt aaagttccag tgcttccaat tttcaaaacc   900
cttgaaaaat acggtcagat taaacacgaa gaaatgtttg aaatcttcaa tatgggtgtg   960
ggacttatgt tggcggtcag ccctgaaaat gtagagcgtg taaaagaatt gttggatgaa   1020
gcagtctatg aaattggtcg catcgtcaag aaagaaaacg aaagtgtcat tatcaaa      1077

<210>   4804
<211>   359
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoribosylformylglycinamide cyclo-ligase (purM)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902092 (0.E+01)

<400>   4804
Met Val Tyr Leu Lys Ile Arg Arg Ser Leu Ser Gln Lys Lys Lys Arg 
1               5                   10                  15      

Lys Asn Lys Met Ala Asn Lys Asn Ala Tyr Ala Gln Ser Gly Val Asp 
            20                  25                  30          

Val Glu Ala Gly Tyr Glu Val Val Glu Arg Ile Lys Lys His Val Ala 
        35                  40                  45              

Arg Thr Glu Arg Ala Gly Val Met Gly Ala Leu Gly Gly Phe Gly Gly 
    50                  55                  60                  

Met Phe Asp Leu Ser Lys Thr Gly Val Lys Glu Pro Val Leu Ile Ser 
65                  70                  75                  80  

Gly Thr Asp Gly Val Gly Thr Lys Leu Met Leu Ala Ile Lys Tyr Asp 
                85                  90                  95      

Lys His Asp Thr Ile Gly Gln Asp Cys Val Ala Met Cys Val Asn Asp 
            100                 105                 110         

Ile Ile Ala Ala Gly Ala Glu Pro Leu Tyr Phe Leu Asp Tyr Val Ala 
        115                 120                 125             

Thr Gly Lys Asn Glu Pro Ala Lys Leu Glu Gln Val Val Ala Gly Val 
    130                 135                 140                 

Ala Glu Gly Cys Val Gln Ala Gly Ala Ala Leu Ile Gly Gly Glu Thr 
145                 150                 155                 160 

Ala Glu Met Pro Gly Met Tyr Gly Glu Asp Asp Tyr Asp Leu Ala Gly 
                165                 170                 175     

Phe Ala Val Gly Val Ala Glu Lys Ser Gln Ile Ile Asp Gly Ser Lys 
            180                 185                 190         

Val Val Glu Gly Asp Val Leu Leu Gly Leu Ala Ser Ser Gly Ile His 
        195                 200                 205             

Ser Asn Gly Tyr Ser Leu Val Arg Arg Val Phe Ala Asp Tyr Thr Gly 
    210                 215                 220                 

Glu Glu Val Leu Pro Glu Leu Glu Gly Lys Lys Leu Lys Glu Val Leu 
225                 230                 235                 240 

Leu Glu Pro Thr Arg Ile Tyr Val Lys Ala Val Leu Pro Leu Ile Lys 
                245                 250                 255     

Glu Glu Leu Val Asn Gly Ile Ala His Ile Thr Gly Gly Gly Phe Ile 
            260                 265                 270         

Glu Asn Val Pro Arg Met Phe Ala Asp Asp Leu Ala Ala Glu Ile Asp 
        275                 280                 285             

Glu Ser Lys Val Pro Val Leu Pro Ile Phe Lys Thr Leu Glu Lys Tyr 
    290                 295                 300                 

Gly Gln Ile Lys His Glu Glu Met Phe Glu Ile Phe Asn Met Gly Val 
305                 310                 315                 320 

Gly Leu Met Leu Ala Val Ser Pro Glu Asn Val Glu Arg Val Lys Glu 
                325                 330                 335     

Leu Leu Asp Glu Ala Val Tyr Glu Ile Gly Arg Ile Val Lys Lys Glu 
            340                 345                 350         

Asn Glu Ser Val Ile Ile Lys 
        355                 

<210>   4805
<211>   543
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4805
atgaaaaaaa tagcggtttt tgcctctggt aatggctcaa attttcaggt gattgccgaa   60
gaatttccag tggagtttgt cttttcagac catcgtgatg cctatgtgct tgagcgtgca   120
aagcagctcg gcgttctgtc ctatgctttt gaactcaagg agtttgagag caaggcagac   180
tacgaagcag cccttgtcga actcttggaa gaacaccaga ttgacttggt ttgcctagca   240
ggctacatga aaatcgttgg accaacctta ttgtcggctt atgaaggtcg gattgtcaac   300
attcatccag cctacttgcc agaatttcca ggagctcatg ggattgagga tgcttggaat   360
gctggcgtgg gtcagtctgg tgtgaccatt cactgggtgg attcgggtgt ggatacaggc   420
caggtcatca aacaggttcg tgtgccacga ctagctgatg ataccattga cagatttgaa   480
gctcgcatcc atgaagcaga gtacaggctg tatccggaag tagtgaaggc tctatttaca   540
gat                                                                 543

<210>   4806
<211>   181
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoribosylglycinamide formyltransferase (purN)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902093 (e-102)

<400>   4806
Met Lys Lys Ile Ala Val Phe Ala Ser Gly Asn Gly Ser Asn Phe Gln 
1               5                   10                  15      

Val Ile Ala Glu Glu Phe Pro Val Glu Phe Val Phe Ser Asp His Arg 
            20                  25                  30          

Asp Ala Tyr Val Leu Glu Arg Ala Lys Gln Leu Gly Val Leu Ser Tyr 
        35                  40                  45              

Ala Phe Glu Leu Lys Glu Phe Glu Ser Lys Ala Asp Tyr Glu Ala Ala 
    50                  55                  60                  

Leu Val Glu Leu Leu Glu Glu His Gln Ile Asp Leu Val Cys Leu Ala 
65                  70                  75                  80  

Gly Tyr Met Lys Ile Val Gly Pro Thr Leu Leu Ser Ala Tyr Glu Gly 
                85                  90                  95      

Arg Ile Val Asn Ile His Pro Ala Tyr Leu Pro Glu Phe Pro Gly Ala 
            100                 105                 110         

His Gly Ile Glu Asp Ala Trp Asn Ala Gly Val Gly Gln Ser Gly Val 
        115                 120                 125             

Thr Ile His Trp Val Asp Ser Gly Val Asp Thr Gly Gln Val Ile Lys 
    130                 135                 140                 

Gln Val Arg Val Pro Arg Leu Ala Asp Asp Thr Ile Asp Arg Phe Glu 
145                 150                 155                 160 

Ala Arg Ile His Glu Ala Glu Tyr Arg Leu Tyr Pro Glu Val Val Lys 
                165                 170                 175     

Ala Leu Phe Thr Asp 
            180     

<210>   4807
<211>   507
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4807
atgttagaat ctaaaaaaac aactcgatat gtattttatg tctatctgat gttattaact   60
tggggaatct tatttaagtt tgaaacaaat cctgaattta tagcattttt cttagctcca   120
aggtatatca attggattcc attttcagaa ccactaatag tcgatggaaa aattgttttt   180
gctgaaatgt tatttaatct gattttcttt attccattag gtgtttgttt ccctttgata   240
aaaactaatt tatctagttt aagaatagtc gggacaggtt tcttgattag tttattgttt   300
gagtgcttac agtatatttt agcaataggt ataacagata taacggattt gactttaaat   360
acgctaggtg tctgtgtagg cttactgatt tatcaaattt ttataagagt gttcaaatca   420
cagactagaa aatggatcaa tatcttaggt atgcttagcc ttggttttgc ttatcttgtt   480
ttactgttac tgcatttact tagtgtt                                       507

<210>   4808
<211>   169
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   vanZ protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902094 (1.E-92)

<400>   4808
Met Leu Glu Ser Lys Lys Thr Thr Arg Tyr Val Phe Tyr Val Tyr Leu 
1               5                   10                  15      

Met Leu Leu Thr Trp Gly Ile Leu Phe Lys Phe Glu Thr Asn Pro Glu 
            20                  25                  30          

Phe Ile Ala Phe Phe Leu Ala Pro Arg Tyr Ile Asn Trp Ile Pro Phe 
        35                  40                  45              

Ser Glu Pro Leu Ile Val Asp Gly Lys Ile Val Phe Ala Glu Met Leu 
    50                  55                  60                  

Phe Asn Leu Ile Phe Phe Ile Pro Leu Gly Val Cys Phe Pro Leu Ile 
65                  70                  75                  80  

Lys Thr Asn Leu Ser Ser Leu Arg Ile Val Gly Thr Gly Phe Leu Ile 
                85                  90                  95      

Ser Leu Leu Phe Glu Cys Leu Gln Tyr Ile Leu Ala Ile Gly Ile Thr 
            100                 105                 110         

Asp Ile Thr Asp Leu Thr Leu Asn Thr Leu Gly Val Cys Val Gly Leu 
        115                 120                 125             

Leu Ile Tyr Gln Ile Phe Ile Arg Val Phe Lys Ser Gln Thr Arg Lys 
    130                 135                 140                 

Trp Ile Asn Ile Leu Gly Met Leu Ser Leu Gly Phe Ala Tyr Leu Val 
145                 150                 155                 160 

Leu Leu Leu Leu His Leu Leu Ser Val 
                165                 

<210>   4809
<211>   1545
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4809
atgactaaac gcgtcttaat cagcgtctca gacaaagcgg gcattgttga atttgcccaa   60
gaactcaaaa aacttggttg ggagattatc tcaacaggtg gaactaaggt tgcccttgat   120
aatgctgggg tggataccat tgctatcgat gatgtgactg gtttcccaga aatgatggac   180
ggtcgtgtga agaccctcca cccaaatatc cacggagggc ttctcgctcg tcgtgacttg   240
gatagccact tggaagcggc taaggacaac aagattgagc tcattgacct tgtggtggtc   300
aacctttacc catttaagga aactatcctt aaaccagatg tgacttatgc tgatgcagtt   360
gaaaatatcg atattggtgg gccatctatg cttcgttcag cagcgaaaaa tcatgccagt   420
gttacagttg tggtagatcc tgctgactac gctgtggttt tggatgaatt ggcagcaaac   480
ggcgaaacct cttatgaaac tcgccaacgt ttagcagcca aagtatttcg tcacacagcg   540
gcttatgacg ccttgattgc agaatacttc acagctcaag tgggtgaaag caagcctgaa   600
aaactcactt tgacttatga cctcaagcaa ccaatgcgtt acggtgagaa tcctcaacaa   660
gacgcggact tttaccagaa agctttgcct acagactact ccattgcttc agccaaacag   720
ctcaacggga aagaattgtc atttaataat atccgtgatg cagatgctgc tatccgtatc   780
atccgtgact tcaaagatag tccaaccgtt gtggctctca aacacatgaa tccatgtgga   840
attggtcaag ctgatgacat cgagactgct tgggactacg cttatgagtc tgacccagtg   900
tctatctttg gtgggattgt cgtcctcaac cgtgaggtgg atgctgcgac agctgagaag   960
atgcacggcg ttttcctcga aatcatcatt gcaccaagct atacggatga agcgctagcc   1020
attttgatca ataaaaagaa aaacttgcgt atccttgcct tgccatttaa tgctcaagag   1080
gctagcgaag tggaagcaga atacacaggt gtagtcggtg gacttctcgt gcaaaatcaa   1140
gacgtggtca aggaaagccc agctgactgg caagtggtga ctaaacgtca gccaactgag   1200
acagaagcga ctgctcttga gttcgcttgg aaggctatca agtacgtcaa atcaaatggt   1260
attatcgtga ccaacgacca catgacactt ggtgttggtc caggtcaaac caaccgtgtg   1320
gcttctgttc gccttgccat tgaccaagcc aaagatcgtc tggacggggc ggtccttgct   1380
tcagatgcct tcttcccatt tgcggataac gtggaagaaa tcgccaaagc aggaattaag   1440
gccatcatcc agcccggtgg ctctgtccgt gaccaagaat ccatcgaagc agcggataaa   1500
tacggcttga ctatggtctt tacaggtgtg agacatttta gacat                   1545

<210>   4810
<211>   515
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydr
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902095 (0.E+01)

<400>   4810
Met Thr Lys Arg Val Leu Ile Ser Val Ser Asp Lys Ala Gly Ile Val 
1               5                   10                  15      

Glu Phe Ala Gln Glu Leu Lys Lys Leu Gly Trp Glu Ile Ile Ser Thr 
            20                  25                  30          

Gly Gly Thr Lys Val Ala Leu Asp Asn Ala Gly Val Asp Thr Ile Ala 
        35                  40                  45              

Ile Asp Asp Val Thr Gly Phe Pro Glu Met Met Asp Gly Arg Val Lys 
    50                  55                  60                  

Thr Leu His Pro Asn Ile His Gly Gly Leu Leu Ala Arg Arg Asp Leu 
65                  70                  75                  80  

Asp Ser His Leu Glu Ala Ala Lys Asp Asn Lys Ile Glu Leu Ile Asp 
                85                  90                  95      

Leu Val Val Val Asn Leu Tyr Pro Phe Lys Glu Thr Ile Leu Lys Pro 
            100                 105                 110         

Asp Val Thr Tyr Ala Asp Ala Val Glu Asn Ile Asp Ile Gly Gly Pro 
        115                 120                 125             

Ser Met Leu Arg Ser Ala Ala Lys Asn His Ala Ser Val Thr Val Val 
    130                 135                 140                 

Val Asp Pro Ala Asp Tyr Ala Val Val Leu Asp Glu Leu Ala Ala Asn 
145                 150                 155                 160 

Gly Glu Thr Ser Tyr Glu Thr Arg Gln Arg Leu Ala Ala Lys Val Phe 
                165                 170                 175     

Arg His Thr Ala Ala Tyr Asp Ala Leu Ile Ala Glu Tyr Phe Thr Ala 
            180                 185                 190         

Gln Val Gly Glu Ser Lys Pro Glu Lys Leu Thr Leu Thr Tyr Asp Leu 
        195                 200                 205             

Lys Gln Pro Met Arg Tyr Gly Glu Asn Pro Gln Gln Asp Ala Asp Phe 
    210                 215                 220                 

Tyr Gln Lys Ala Leu Pro Thr Asp Tyr Ser Ile Ala Ser Ala Lys Gln 
225                 230                 235                 240 

Leu Asn Gly Lys Glu Leu Ser Phe Asn Asn Ile Arg Asp Ala Asp Ala 
                245                 250                 255     

Ala Ile Arg Ile Ile Arg Asp Phe Lys Asp Ser Pro Thr Val Val Ala 
            260                 265                 270         

Leu Lys His Met Asn Pro Cys Gly Ile Gly Gln Ala Asp Asp Ile Glu 
        275                 280                 285             

Thr Ala Trp Asp Tyr Ala Tyr Glu Ser Asp Pro Val Ser Ile Phe Gly 
    290                 295                 300                 

Gly Ile Val Val Leu Asn Arg Glu Val Asp Ala Ala Thr Ala Glu Lys 
305                 310                 315                 320 

Met His Gly Val Phe Leu Glu Ile Ile Ile Ala Pro Ser Tyr Thr Asp 
                325                 330                 335     

Glu Ala Leu Ala Ile Leu Ile Asn Lys Lys Lys Asn Leu Arg Ile Leu 
            340                 345                 350         

Ala Leu Pro Phe Asn Ala Gln Glu Ala Ser Glu Val Glu Ala Glu Tyr 
        355                 360                 365             

Thr Gly Val Val Gly Gly Leu Leu Val Gln Asn Gln Asp Val Val Lys 
    370                 375                 380                 

Glu Ser Pro Ala Asp Trp Gln Val Val Thr Lys Arg Gln Pro Thr Glu 
385                 390                 395                 400 

Thr Glu Ala Thr Ala Leu Glu Phe Ala Trp Lys Ala Ile Lys Tyr Val 
                405                 410                 415     

Lys Ser Asn Gly Ile Ile Val Thr Asn Asp His Met Thr Leu Gly Val 
            420                 425                 430         

Gly Pro Gly Gln Thr Asn Arg Val Ala Ser Val Arg Leu Ala Ile Asp 
        435                 440                 445             

Gln Ala Lys Asp Arg Leu Asp Gly Ala Val Leu Ala Ser Asp Ala Phe 
    450                 455                 460                 

Phe Pro Phe Ala Asp Asn Val Glu Glu Ile Ala Lys Ala Gly Ile Lys 
465                 470                 475                 480 

Ala Ile Ile Gln Pro Gly Gly Ser Val Arg Asp Gln Glu Ser Ile Glu 
                485                 490                 495     

Ala Ala Asp Lys Tyr Gly Leu Thr Met Val Phe Thr Gly Val Arg His 
            500                 505                 510         

Phe Arg His 
        515 

<210>   4811
<211>   1260
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4811
atgaaactgc ttgttgtcgg ttctggtggt cgtgagcatg cgattgctaa aaagttactt   60
gaatcaaaag acgtggaaaa agtctttgta gctcctggga atgatgggat gactctggat   120
ggtttggaat tggtaaatat ctctatttcc gaacattata aattgattga cttcgcaaag   180
accaatgatg ttgcttggac ctttatcggt ccagatgatg cccttgctgc tggtatcgtg   240
gatgatttta accaagctgg acttaaggcc tttggtccga ctagggctgc agcggagctg   300
gagtggtcca aggatttcgc caaggaaatc atggtcaaat acggcgttcc gacagcaaca   360
tatggcacat tttcagattt cgaggaagcc aaagcctata tcgaaaagca tggtgcgcct   420
atcgtagtca aggcggatgg cttggcactt gggaagggtg tcgtcgttgc tgagacggtt   480

gagcaagcgg tcgaagccgc tcatgagatg cttttggaca ataaatttgg tgactcaggt   540
gcgcgcgtgg ttattgagga attccttgaa ggagaggaat tttcactctt tgcctttgtc   600
aatggtgata agttctacat catgccaacg gctcaggacc acaaacgtgc ctatgatggc   660
gacaaagggc ctaacacggg tggtatgggt gcctatgcgc cagtcccaca cttaccacag   720
agtgtagttg atacagcggt tgacaccatt gtcaagccag ttctagaagg ggtgattaaa   780
gaaggtcgcc cttatctggg agttctttac gcagggctta tcctgacagc tgatggaccg   840
aaagtcattg agttcaacgc tcggttcgga gatccagaaa ctcagattat cttgcctcgc   900
ttgacctctg actttgctca aaatatcaca gatatcctgg atagcaagga gccaaatatc   960
atgtggacgg acaagggtgt gactctgggt gtggttgtcg catccaaggg ctacccgcta   1020
gactatgaaa ggggcgttga gttgccagcc aagacagaag gcgatgtcat cacctactat   1080
gcaggggcta agtttgcgga aaatagcaga gcactgctct caaacggcgg acgagtttat   1140
atgctcgtta ccacagcaga taccgtcaaa gaagcccaag ccagcatata ccaagaacta   1200
taccaacaaa aaatagaagg actcttctac cgaacagata tcggaagcaa ggcaattaag   1260

<210>   4812
<211>   420
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoribosylamine--glycine ligase (purD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902096 (0.E+01)

<400>   4812
Met Lys Leu Leu Val Val Gly Ser Gly Gly Arg Glu His Ala Ile Ala 
1               5                   10                  15      

Lys Lys Leu Leu Glu Ser Lys Asp Val Glu Lys Val Phe Val Ala Pro 
            20                  25                  30          

Gly Asn Asp Gly Met Thr Leu Asp Gly Leu Glu Leu Val Asn Ile Ser 
        35                  40                  45              

Ile Ser Glu His Tyr Lys Leu Ile Asp Phe Ala Lys Thr Asn Asp Val 
    50                  55                  60                  

Ala Trp Thr Phe Ile Gly Pro Asp Asp Ala Leu Ala Ala Gly Ile Val 
65                  70                  75                  80  

Asp Asp Phe Asn Gln Ala Gly Leu Lys Ala Phe Gly Pro Thr Arg Ala 
                85                  90                  95      

Ala Ala Glu Leu Glu Trp Ser Lys Asp Phe Ala Lys Glu Ile Met Val 
            100                 105                 110         

Lys Tyr Gly Val Pro Thr Ala Thr Tyr Gly Thr Phe Ser Asp Phe Glu 
        115                 120                 125             

Glu Ala Lys Ala Tyr Ile Glu Lys His Gly Ala Pro Ile Val Val Lys 
    130                 135                 140                 

Ala Asp Gly Leu Ala Leu Gly Lys Gly Val Val Val Ala Glu Thr Val 
145                 150                 155                 160 

Glu Gln Ala Val Glu Ala Ala His Glu Met Leu Leu Asp Asn Lys Phe 
                165                 170                 175     

Gly Asp Ser Gly Ala Arg Val Val Ile Glu Glu Phe Leu Glu Gly Glu 
            180                 185                 190         

Glu Phe Ser Leu Phe Ala Phe Val Asn Gly Asp Lys Phe Tyr Ile Met 
        195                 200                 205             

Pro Thr Ala Gln Asp His Lys Arg Ala Tyr Asp Gly Asp Lys Gly Pro 
    210                 215                 220                 

Asn Thr Gly Gly Met Gly Ala Tyr Ala Pro Val Pro His Leu Pro Gln 
225                 230                 235                 240 

Ser Val Val Asp Thr Ala Val Asp Thr Ile Val Lys Pro Val Leu Glu 
                245                 250                 255     

Gly Val Ile Lys Glu Gly Arg Pro Tyr Leu Gly Val Leu Tyr Ala Gly 
            260                 265                 270         

Leu Ile Leu Thr Ala Asp Gly Pro Lys Val Ile Glu Phe Asn Ala Arg 
        275                 280                 285             

Phe Gly Asp Pro Glu Thr Gln Ile Ile Leu Pro Arg Leu Thr Ser Asp 
    290                 295                 300                 

Phe Ala Gln Asn Ile Thr Asp Ile Leu Asp Ser Lys Glu Pro Asn Ile 
305                 310                 315                 320 

Met Trp Thr Asp Lys Gly Val Thr Leu Gly Val Val Val Ala Ser Lys 
                325                 330                 335     

Gly Tyr Pro Leu Asp Tyr Glu Arg Gly Val Glu Leu Pro Ala Lys Thr 
            340                 345                 350         

Glu Gly Asp Val Ile Thr Tyr Tyr Ala Gly Ala Lys Phe Ala Glu Asn 
        355                 360                 365             

Ser Arg Ala Leu Leu Ser Asn Gly Gly Arg Val Tyr Met Leu Val Thr 
    370                 375                 380                 

Thr Ala Asp Thr Val Lys Glu Ala Gln Ala Ser Ile Tyr Gln Glu Leu 
385                 390                 395                 400 

Tyr Gln Gln Lys Ile Glu Gly Leu Phe Tyr Arg Thr Asp Ile Gly Ser 
                405                 410                 415     

Lys Ala Ile Lys 
            420 

<210>   4813
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4813
gtgaaagaac gattggatga taatccaatc gttcagggaa attggaagac cttgggtttc   60
caatttaggc atgagacacc tttggtggct gctgccgtcc ctcacaagct aagg         114


<210>   4814
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4814
Met Lys Glu Arg Leu Asp Asp Asn Pro Ile Val Gln Gly Asn Trp Lys 
1               5                   10                  15      

Thr Leu Gly Phe Gln Phe Arg His Glu Thr Pro Leu Val Ala Ala Ala 
            20                  25                  30          

Val Pro His Lys Leu Arg 
        35              

<210>   4815
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4815
atgatgatgg aaattactgg tttcatttct tctccttttt cctctttttc aacaatcacc   60
ttagcttgtg agggacggca gcagccacca aaggtgtctc atgcc                   105

<210>   4816
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4816
Met Met Met Glu Ile Thr Gly Phe Ile Ser Ser Pro Phe Ser Ser Phe 
1               5                   10                  15      

Ser Thr Ile Thr Leu Ala Cys Glu Gly Arg Gln Gln Pro Pro Lys Val 
            20                  25                  30          

Ser His Ala 
        35  

<210>   4817
<211>   486
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4817
atgaaaccag taatttccat catcatgggc tcaaaatccg actgggcaac catgcaaaaa   60
acagcagaag tcctagaccg cttcggtgta gcctacgaaa agaaagttgt ttccgcacac   120
cgtacaccag acctcatgtt caaacatgca gaagaagccc gtagtcgtgg catcaagatc   180
atcatcgcag gtgctggtgg cgcagcgcat ttgccaggca tggtagctgc caaaacaacc   240
cttccagtca ttggtgtgcc agtcaagtct cgtgctctta gtggagtgga ttcactctat   300
tctatcgttc agatgccggg tggggtgcct gttgcgacca tggctatcgg tgaagctgga   360
gcgactaacg cagctctctt tgccctccgt ctcctctctg tagaagataa gtccattgcg   420
gatgcacttg ccaactttgc tgaagaacaa ggaaaaatcg cagaggagtc gtcaaatgag   480
ctcatc                                                              486

<210>   4818
<211>   162
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoribosylaminoimidazole carboxylase, catalytic subunit (purE)
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902097 (3.E-86)

<400>   4818
Met Lys Pro Val Ile Ser Ile Ile Met Gly Ser Lys Ser Asp Trp Ala 
1               5                   10                  15      

Thr Met Gln Lys Thr Ala Glu Val Leu Asp Arg Phe Gly Val Ala Tyr 
            20                  25                  30          


Glu Lys Lys Val Val Ser Ala His Arg Thr Pro Asp Leu Met Phe Lys 
        35                  40                  45              

His Ala Glu Glu Ala Arg Ser Arg Gly Ile Lys Ile Ile Ile Ala Gly 
    50                  55                  60                  

Ala Gly Gly Ala Ala His Leu Pro Gly Met Val Ala Ala Lys Thr Thr 
65                  70                  75                  80  

Leu Pro Val Ile Gly Val Pro Val Lys Ser Arg Ala Leu Ser Gly Val 
                85                  90                  95      

Asp Ser Leu Tyr Ser Ile Val Gln Met Pro Gly Gly Val Pro Val Ala 
            100                 105                 110         

Thr Met Ala Ile Gly Glu Ala Gly Ala Thr Asn Ala Ala Leu Phe Ala 
        115                 120                 125             

Leu Arg Leu Leu Ser Val Glu Asp Lys Ser Ile Ala Asp Ala Leu Ala 
    130                 135                 140                 

Asn Phe Ala Glu Glu Gln Gly Lys Ile Ala Glu Glu Ser Ser Asn Glu 
145                 150                 155                 160 

Leu Ile 
        

<210>   4819
<211>   1089
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4819
atgagctcat ctaaaacaat cggaattatc ggtggcggtc aactgggtca gatgatggcc   60
atttctgcta tctacatggg ccacaaggtt atcgcgctgg atcctgcggc ggattgcccg   120
gtctctcgtg tggcggaaat cattgtggca ccttataacg atgtagacgc cctccgtcag   180
ttggcagacc gttgcgatgt cctcacttat gagtttgaaa atgtcgacgc tgacggtttg   240
gatgccgtta tcaaggatgg acaactccct caaggaacag atctgctccg catttcgcaa   300
aatcgtattt ttgaaaagga ctttttgtca aacaaggctc aagtcactgt ggcaccctac   360
aaggtcgtga cttctagcct agacttggca gatatcgact tgtcgaaaaa ctatgtcctc   420
aagactgcga ctggtggcta cgatggtcat ggacaaaagg ttattcgttc agaagcagac   480
ttggaagcag cctatgcgct agcagactca gcagactgcg tcttggaaga atttgtcaac   540
tttgaccttg agatttctgt catcgtgtca ggaaatggca aggaggtgac gtttttccca   600
gttcaggaaa atatccaccg caacaatatc ctgtctaaga ccatcgtacc agcccgcatt   660
tctgaaagtc tagtagacaa ggctaaagct atggcagtgc gaatcgcaga acaactcaac   720
ttgtctggaa ctctctgtgt ggaaatgttt gcgacagctg atgacatcat tgtcaatgaa   780
atcgccccac gaccacataa ctctgggcac tattctattg aagcctgtga tttctctcag   840
tttgacaccc atattctggg tgttctcgga gcaccattac cagtcatcaa actccatgcg   900
ccagccgtta tgcttaatgt cctcggtcag catgtcgagg ctgctgaaaa atatgtcaca   960
gaaaatccaa gcgcccacct ccacatgtat ggtaaaatag aagcaaagca taatcgtaag   1020
atgggacatg tgactttgtt tagtgatgtg ccggatagtg tggaagagtt tggggaaggg   1080
attgatttt                                                           1089

<210>   4820
<211>   363
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphoribosylaminoimidazole carboxylase, ATPase subunit (purK)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902098 (0.E+01)

<400>   4820
Met Ser Ser Ser Lys Thr Ile Gly Ile Ile Gly Gly Gly Gln Leu Gly 

1               5                   10                  15      

Gln Met Met Ala Ile Ser Ala Ile Tyr Met Gly His Lys Val Ile Ala 
            20                  25                  30          

Leu Asp Pro Ala Ala Asp Cys Pro Val Ser Arg Val Ala Glu Ile Ile 
        35                  40                  45              

Val Ala Pro Tyr Asn Asp Val Asp Ala Leu Arg Gln Leu Ala Asp Arg 
    50                  55                  60                  

Cys Asp Val Leu Thr Tyr Glu Phe Glu Asn Val Asp Ala Asp Gly Leu 
65                  70                  75                  80  

Asp Ala Val Ile Lys Asp Gly Gln Leu Pro Gln Gly Thr Asp Leu Leu 
                85                  90                  95      

Arg Ile Ser Gln Asn Arg Ile Phe Glu Lys Asp Phe Leu Ser Asn Lys 
            100                 105                 110         

Ala Gln Val Thr Val Ala Pro Tyr Lys Val Val Thr Ser Ser Leu Asp 
        115                 120                 125             

Leu Ala Asp Ile Asp Leu Ser Lys Asn Tyr Val Leu Lys Thr Ala Thr 
    130                 135                 140                 

Gly Gly Tyr Asp Gly His Gly Gln Lys Val Ile Arg Ser Glu Ala Asp 
145                 150                 155                 160 

Leu Glu Ala Ala Tyr Ala Leu Ala Asp Ser Ala Asp Cys Val Leu Glu 
                165                 170                 175     

Glu Phe Val Asn Phe Asp Leu Glu Ile Ser Val Ile Val Ser Gly Asn 
            180                 185                 190         

Gly Lys Glu Val Thr Phe Phe Pro Val Gln Glu Asn Ile His Arg Asn 
        195                 200                 205             

Asn Ile Leu Ser Lys Thr Ile Val Pro Ala Arg Ile Ser Glu Ser Leu 
    210                 215                 220                 

Val Asp Lys Ala Lys Ala Met Ala Val Arg Ile Ala Glu Gln Leu Asn 
225                 230                 235                 240 

Leu Ser Gly Thr Leu Cys Val Glu Met Phe Ala Thr Ala Asp Asp Ile 
                245                 250                 255     

Ile Val Asn Glu Ile Ala Pro Arg Pro His Asn Ser Gly His Tyr Ser 
            260                 265                 270         

Ile Glu Ala Cys Asp Phe Ser Gln Phe Asp Thr His Ile Leu Gly Val 
        275                 280                 285             

Leu Gly Ala Pro Leu Pro Val Ile Lys Leu His Ala Pro Ala Val Met 
    290                 295                 300                 

Leu Asn Val Leu Gly Gln His Val Glu Ala Ala Glu Lys Tyr Val Thr 
305                 310                 315                 320 

Glu Asn Pro Ser Ala His Leu His Met Tyr Gly Lys Ile Glu Ala Lys 
                325                 330                 335     

His Asn Arg Lys Met Gly His Val Thr Leu Phe Ser Asp Val Pro Asp 
            340                 345                 350         

Ser Val Glu Glu Phe Gly Glu Gly Ile Asp Phe 
        355                 360             

<210>   4821
<211>   225
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4821
atgatacaaa ttatcgttaa tacatttatt gaaaagtata agactggagc agttgttgaa   60
gtgttgtatg ccagtgctga ccaagataag gtacaagcta aatatgaaga actagctgca   120
caataccccg aaaattattt agctatctat aatgtaccgc tggatacgga tttgaataca   180
ctagatcatt acccgtctgt gtttattgga aaagaggagt ttgag                   225

<210>   4822
<211>   75
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902099 (1.E-36)

<400>   4822
Met Ile Gln Ile Ile Val Asn Thr Phe Ile Glu Lys Tyr Lys Thr Gly 
1               5                   10                  15      

Ala Val Val Glu Val Leu Tyr Ala Ser Ala Asp Gln Asp Lys Val Gln 
            20                  25                  30          

Ala Lys Tyr Glu Glu Leu Ala Ala Gln Tyr Pro Glu Asn Tyr Leu Ala 
        35                  40                  45              

Ile Tyr Asn Val Pro Leu Asp Thr Asp Leu Asn Thr Leu Asp His Tyr 
    50                  55                  60                  

Pro Ser Val Phe Ile Gly Lys Glu Glu Phe Glu 
65                  70                  75  

<210>   4823
<211>   1296
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4823
atgatcaacc gttactctcg ccctgagatg gcgaatattt ggagtgaaga aaataaatac   60
cgtgcttggc ttgaggtgga aatcctctct gacgaggcat gggctgagtt gggggaaatc   120
cctaaggaag atgtggcttt gattcgcaag aaggcggact ttgacatcga ccgtattttg   180
gaaattgagc aggagacgcg ccacgatgtg gtggctttca cgcgtgcggt ttctgagact   240
cttggtgaag agcgcaagtg ggttcactat gggttaactt ctactgacgt ggtggatact   300
gcttatggtt acctctacaa gcaggccaac gacatcatcc gtcgtgacct tgaaaacttc   360
actaatatca tcgctgacaa ggccaaggag cacaagttca ccatcatgat ggggcgtact   420
catggtgtgc acgctgagcc gacaaccttt ggtcttaaat tagcaacttg gtacagcgaa   480
atgaaacgca atatcgagcg cttcgagcat gcggctgctg gtgtagaagc tggtaagatt   540

tctggtgcgg ttgggaactt tgccaatatc ccaccatttg tagaggagta tgtctgcgat   600
aaacttggca tccgtgccca agaaatctct acacaagtcc ttcctcgtga ccttcacgct   660
gagtactttg cggttcttgc cagcattgcg acttcaatcg aacgtatggc gactgagatt   720
cgtggtctac aaaaatctga gcaacgcgaa gtagaagagt tctttgctaa agggcaaaaa   780
gggtcttcag caatgcctca caaacgcaac ccaatcggtt ctgaaaatat gactggtctg   840
gcgcgtgtca ttcgtggtca catgattacg gcttatgaaa acgtcgctct ctggcatgaa   900
cgcgatattt ctcactcatc agctgagcgt atcatcacac cagatacgac cattttgatt   960
gactacatgc tcaaccgttt tggaaatatc gtcaagaact tgacagtctt cccagaaaat   1020
atgatccgaa acatgaactc gacttttggt cttatcttta gccaacgggc tatgttgaca   1080
ttgattgaaa aaggcatgac ccgtgagcaa gcctatgact tggtgcaacc aaaaacagcc   1140
tactcttggg acaaccaagt agactttaaa ccacttcttg aggcagattc agaagtaaca   1200
tcacgtctca cacaagaaga aatcgatgaa atcttcaacc cagtttatta caccaaacga   1260
gtggatgata tctttgaacg tcttggacta ggtgat                             1296

<210>   4824
<211>   432
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   adenylosuccinate lyase (purB)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902100 (0.E+01)

<400>   4824
Met Ile Asn Arg Tyr Ser Arg Pro Glu Met Ala Asn Ile Trp Ser Glu 
1               5                   10                  15      

Glu Asn Lys Tyr Arg Ala Trp Leu Glu Val Glu Ile Leu Ser Asp Glu 
            20                  25                  30          

Ala Trp Ala Glu Leu Gly Glu Ile Pro Lys Glu Asp Val Ala Leu Ile 
        35                  40                  45              

Arg Lys Lys Ala Asp Phe Asp Ile Asp Arg Ile Leu Glu Ile Glu Gln 
    50                  55                  60                  

Glu Thr Arg His Asp Val Val Ala Phe Thr Arg Ala Val Ser Glu Thr 
65                  70                  75                  80  

Leu Gly Glu Glu Arg Lys Trp Val His Tyr Gly Leu Thr Ser Thr Asp 
                85                  90                  95      

Val Val Asp Thr Ala Tyr Gly Tyr Leu Tyr Lys Gln Ala Asn Asp Ile 
            100                 105                 110         

Ile Arg Arg Asp Leu Glu Asn Phe Thr Asn Ile Ile Ala Asp Lys Ala 
        115                 120                 125             

Lys Glu His Lys Phe Thr Ile Met Met Gly Arg Thr His Gly Val His 
    130                 135                 140                 

Ala Glu Pro Thr Thr Phe Gly Leu Lys Leu Ala Thr Trp Tyr Ser Glu 
145                 150                 155                 160 

Met Lys Arg Asn Ile Glu Arg Phe Glu His Ala Ala Ala Gly Val Glu 
                165                 170                 175     

Ala Gly Lys Ile Ser Gly Ala Val Gly Asn Phe Ala Asn Ile Pro Pro 
            180                 185                 190         

Phe Val Glu Glu Tyr Val Cys Asp Lys Leu Gly Ile Arg Ala Gln Glu 
        195                 200                 205             

Ile Ser Thr Gln Val Leu Pro Arg Asp Leu His Ala Glu Tyr Phe Ala 
    210                 215                 220                 

Val Leu Ala Ser Ile Ala Thr Ser Ile Glu Arg Met Ala Thr Glu Ile 
225                 230                 235                 240 

Arg Gly Leu Gln Lys Ser Glu Gln Arg Glu Val Glu Glu Phe Phe Ala 
                245                 250                 255     

Lys Gly Gln Lys Gly Ser Ser Ala Met Pro His Lys Arg Asn Pro Ile 
            260                 265                 270         

Gly Ser Glu Asn Met Thr Gly Leu Ala Arg Val Ile Arg Gly His Met 
        275                 280                 285             

Ile Thr Ala Tyr Glu Asn Val Ala Leu Trp His Glu Arg Asp Ile Ser 
    290                 295                 300                 

His Ser Ser Ala Glu Arg Ile Ile Thr Pro Asp Thr Thr Ile Leu Ile 
305                 310                 315                 320 

Asp Tyr Met Leu Asn Arg Phe Gly Asn Ile Val Lys Asn Leu Thr Val 
                325                 330                 335     

Phe Pro Glu Asn Met Ile Arg Asn Met Asn Ser Thr Phe Gly Leu Ile 
            340                 345                 350         

Phe Ser Gln Arg Ala Met Leu Thr Leu Ile Glu Lys Gly Met Thr Arg 
        355                 360                 365             

Glu Gln Ala Tyr Asp Leu Val Gln Pro Lys Thr Ala Tyr Ser Trp Asp 
    370                 375                 380                 

Asn Gln Val Asp Phe Lys Pro Leu Leu Glu Ala Asp Ser Glu Val Thr 
385                 390                 395                 400 

Ser Arg Leu Thr Gln Glu Glu Ile Asp Glu Ile Phe Asn Pro Val Tyr 
                405                 410                 415     

Tyr Thr Lys Arg Val Asp Asp Ile Phe Glu Arg Leu Gly Leu Gly Asp 
            420                 425                 430         


<210>   4825
<211>   3987
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4825
ttgatttata taatcgctat caatataaca atgcaatcag gaggttttgc aatgaaacat   60
gaaaaacaac agcgtttttc tattcgtaaa tacgctgtag gagcagcttc tgttctaatt   120
ggatttgcct tccaagcaca gactgttgca gccgatggag ttactcctac tactacagaa   180
aaccaaccga ccatccatac ggtttctgat tcccctcaat catccgaaaa tcggactgag   240
gaaacaccta aagcagtgct tcaaccagaa gctccaaaaa ctgtagaaac agaaactcca   300
gctactgata aggtagctag tcttccaaaa acagaagaaa aaccacaaga ggaagttagt   360
tcaactccta gtgataaagc agaagtggta actccaactt ctgctgaaaa agaaactgct   420
aataaaaagg cagaagaagc tagccctaaa aaggaagaag cgaaagaggt tgattctaaa   480
gagtcaaata cagacaagac tgacaaggat aaaccagcta aaaaagatga agcgaaagca   540
gaggctgaca aaccggcaac agaggcagga aaggaacgtg ctgcaactgt aaatgaaaaa   600
ctagcgaaaa agaaaattgt ttctattgat gctggacgta aatatttctc accagaacag   660
ctcaaggaaa tcatcgataa agcgaaacat tatggctaca ctgatttaca cctattagtc   720
ggaaatgatg gactccgttt catgttggac gatatgagca tcacagctaa cggcaagacc   780
tatgccagtg acgatgtcaa acgcgccatt gaaaaaggta caaatgatta ttacaacgat   840
ccaaacggca atcacttaac agaaagtcaa atgacagatc tgattaacta tgccaaagat   900
aaaggtatcg gtctcattcc gacagtaaat agtcctggac acatggatgc gattctcaat   960
gccatgaaag aattgggaat ccaaaaccct aactttagct attttgggaa gaaatcagcc   1020
cgtactgtcg atcttgacaa cgaacaagct gtcgctttta caaaagccct tatcgacaag   1080
tatgctgctt atttcgcgaa aaagactgaa atcttcaaca tcggacttga tgaatatgcc   1140
aatgatgcga cagatgctaa aggttggagt gtgcttcaag ctgataaata ctatccaaac   1200
gaaggctacc ctgtaaaagg ctatgaaaaa tttattgcct acgccaatga cctcgctcgt   1260
attgtaaaat cgcacggtct caaaccaatg gcttttaacg acggtatcta ctacaatagc   1320
gacacaagct ttggtagttt tgacaaagac atcatcgttt ctatgtggac tggtggttgg   1380
ggaggctacg atgtcgcttc ttctaaacta ctagctgaaa aaggtcacca aatccttaat   1440
accaatgatg cttggtacta cgttcttgga cgaaacgctg atggccaagg ctggtacaat   1500
ctcgatcagg ggctcaatgg tattaaaaac acaccaatca cttctgtacc aaaaacagaa   1560
ggagctgata tcccaatcat cggtggtatg gtagctgctt gggctgacac tccatctgca   1620
cgttattcac catcacgcct cttcaaactc atgcgtcatt ttgcaaatgc caacgctgaa   1680
tacttcgcag ctgattatga atctgcagag caagcactta acgaggtacc aaaagacctg   1740
aaccgttata ctgcagaaag cgtcacggcc gtaaaagaag ctgaaaaagc tattcgctct   1800
ctcgatagca accttagccg tgcccaacaa gatacgattg atcaagccat tgctaaactt   1860
caagaaactg tcaacaactt gaccctcacg cctgaagctc aaaaagaaga agaagctaaa   1920
cgtgaggttg aaaaacttgc caaaaacaag gtaatctcaa tcgatgctgg acgcaaatac   1980
tttactctga accagctcaa acgcatcgta gacaaggcca gtgagctcgg atattctgat   2040
gtccatctcc ttctaggaaa tgacggactt cgctttctac tcgatgatat gaccattact   2100
gccaacggaa aaacctatgc tagtgatgac gttaaaaaag ctattatcga aggaactaaa   2160
gcttactacg acgatccaaa cggtactgca ctaacacagg cagaagtaac agagctaatt   2220
gaatacgcta aatctaagga catcggtctc atcccagcta ttaacagtcc aggtcacatg   2280
gatgctatgc tggttgccat ggaaaaatta ggtattaaaa atcctcaagc ccactttgat   2340
aaagtttcaa aaacaactat ggacttgaaa aacgaagaag cgatgaactt tgtaaaagcc   2400
ctcatcggta aatacatgga cttctttgca ggtaaaacaa agattttcaa ctttggtact   2460
gacgaatacg ccaacgatgc gactagtgcc caaggctggt actacctcaa gtggtatcaa   2520
ctctatggca aatttgccga atatgccaac accctcgcag ctatggccaa agaaagaggg   2580
cttcaaccaa tggccttcaa cgatggcttc tactatgaag acaaggacga tgttcagttt   2640
gacaaagatg tcttgatttc ttactggtct aaaggctggt ggggatataa cctcgcatca   2700
cctcaatacc tagcaagcaa aggctataaa ttcttgaata ccaacggtga ctggtactac   2760
attcttggtc aaaaaccaga agatggtggt ggtttcctca agaaagctat tgagaatact   2820
ggaaaaacac cattcaatca actagcttct accaaatatc ctgaagtaga tcttccaaca   2880
gtcggaagta tgctttcaat ctgggcagat agaccaagcg ctgaatacaa ggaagaggaa   2940
atctttgaac tcatgactgc ctttgcagac cacaacaaag actactttcg tgctaattat   3000
aatgctctcc gcgaagaatt agctaaaatt cctacaaact tagaaggata tagtaaagaa   3060
agtcttgagg cccttgacgc agctaaaaca gctctaaatt acaacctcaa ccgtaataaa   3120
caagctgagc ttgacacgct tgtagccaac ctaaaagccg ctcttcaagg cctcaaacca   3180
gctgtaactc attcaggaag cctagatgaa aatgaagtgg ctgccaatgt tgaaaccaga   3240
ccagaactca tcacaagaac tgaagaaatt ccatttgaag ttatcaagaa agaaaatcct   3300
aacctcccag ccggtcagga aaatattatc acagcaggag tcaaaggtga acgaactcat   3360
tacatctctg tactcactga aaatggaaaa acaacagaaa cagtccttga tagccaggta   3420
accaaagaag ttataaacca agtggttgaa gttggcgctc ctgtaactca caagggtgat   3480
gaaagtggtc ttgcaccaac tactgaggta aaacctagac tggatatcca agaagaagaa   3540
attccattta ccacagtgac ttgtgaaaat ccactcttac tcaaaggaaa aacacaagtc   3600
attactaagg gcgtcaatgg acatcgtagc aacttctact ctgtgagcac ttctgccgat   3660
ggtaaggaag tgaaaacact tgtaaatagt gtcgtagcac aggaagccgt tactcaaata   3720
gtcgaagtcg gaactatggt aacacatgta ggcgatgaaa acggacaagc cgctattgct   3780
gaagaaaaac caaaactaga aatcccaagc caaccagctc catcaactgc tcctgctgag   3840
gaaagcaaag ttcttcctca agatccagct cctgtggtaa cagagaaaaa acttcctgaa   3900
acaggaactc acgattctgc aggactagta gtcgcaggac tcatgtccac actagcagcc   3960
tatggactca ctaaaagaaa agaagac                                       3987

<210>   4826
<211>   1329
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   beta-N-acetylhexosaminidase (strH)
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15902101 (0.E+01)

<400>   4826
Met Ile Tyr Ile Ile Ala Ile Asn Ile Thr Met Gln Ser Gly Gly Phe 
1               5                   10                  15      

Ala Met Lys His Glu Lys Gln Gln Arg Phe Ser Ile Arg Lys Tyr Ala 
            20                  25                  30          

Val Gly Ala Ala Ser Val Leu Ile Gly Phe Ala Phe Gln Ala Gln Thr 
        35                  40                  45              

Val Ala Ala Asp Gly Val Thr Pro Thr Thr Thr Glu Asn Gln Pro Thr 
    50                  55                  60                  

Ile His Thr Val Ser Asp Ser Pro Gln Ser Ser Glu Asn Arg Thr Glu 
65                  70                  75                  80  

Glu Thr Pro Lys Ala Val Leu Gln Pro Glu Ala Pro Lys Thr Val Glu 
                85                  90                  95      

Thr Glu Thr Pro Ala Thr Asp Lys Val Ala Ser Leu Pro Lys Thr Glu 
            100                 105                 110         

Glu Lys Pro Gln Glu Glu Val Ser Ser Thr Pro Ser Asp Lys Ala Glu 
        115                 120                 125             

Val Val Thr Pro Thr Ser Ala Glu Lys Glu Thr Ala Asn Lys Lys Ala 
    130                 135                 140                 

Glu Glu Ala Ser Pro Lys Lys Glu Glu Ala Lys Glu Val Asp Ser Lys 
145                 150                 155                 160 

Glu Ser Asn Thr Asp Lys Thr Asp Lys Asp Lys Pro Ala Lys Lys Asp 
                165                 170                 175     

Glu Ala Lys Ala Glu Ala Asp Lys Pro Ala Thr Glu Ala Gly Lys Glu 
            180                 185                 190         

Arg Ala Ala Thr Val Asn Glu Lys Leu Ala Lys Lys Lys Ile Val Ser 
        195                 200                 205             

Ile Asp Ala Gly Arg Lys Tyr Phe Ser Pro Glu Gln Leu Lys Glu Ile 
    210                 215                 220                 

Ile Asp Lys Ala Lys His Tyr Gly Tyr Thr Asp Leu His Leu Leu Val 
225                 230                 235                 240 

Gly Asn Asp Gly Leu Arg Phe Met Leu Asp Asp Met Ser Ile Thr Ala 
                245                 250                 255     

Asn Gly Lys Thr Tyr Ala Ser Asp Asp Val Lys Arg Ala Ile Glu Lys 
            260                 265                 270         

Gly Thr Asn Asp Tyr Tyr Asn Asp Pro Asn Gly Asn His Leu Thr Glu 
        275                 280                 285             

Ser Gln Met Thr Asp Leu Ile Asn Tyr Ala Lys Asp Lys Gly Ile Gly 
    290                 295                 300                 

Leu Ile Pro Thr Val Asn Ser Pro Gly His Met Asp Ala Ile Leu Asn 
305                 310                 315                 320 

Ala Met Lys Glu Leu Gly Ile Gln Asn Pro Asn Phe Ser Tyr Phe Gly 
                325                 330                 335     

Lys Lys Ser Ala Arg Thr Val Asp Leu Asp Asn Glu Gln Ala Val Ala 
            340                 345                 350         

Phe Thr Lys Ala Leu Ile Asp Lys Tyr Ala Ala Tyr Phe Ala Lys Lys 
        355                 360                 365             

Thr Glu Ile Phe Asn Ile Gly Leu Asp Glu Tyr Ala Asn Asp Ala Thr 
    370                 375                 380                 

Asp Ala Lys Gly Trp Ser Val Leu Gln Ala Asp Lys Tyr Tyr Pro Asn 
385                 390                 395                 400 

Glu Gly Tyr Pro Val Lys Gly Tyr Glu Lys Phe Ile Ala Tyr Ala Asn 
                405                 410                 415     

Asp Leu Ala Arg Ile Val Lys Ser His Gly Leu Lys Pro Met Ala Phe 
            420                 425                 430         

Asn Asp Gly Ile Tyr Tyr Asn Ser Asp Thr Ser Phe Gly Ser Phe Asp 
        435                 440                 445             

Lys Asp Ile Ile Val Ser Met Trp Thr Gly Gly Trp Gly Gly Tyr Asp 
    450                 455                 460                 

Val Ala Ser Ser Lys Leu Leu Ala Glu Lys Gly His Gln Ile Leu Asn 
465                 470                 475                 480 

Thr Asn Asp Ala Trp Tyr Tyr Val Leu Gly Arg Asn Ala Asp Gly Gln 
                485                 490                 495     

Gly Trp Tyr Asn Leu Asp Gln Gly Leu Asn Gly Ile Lys Asn Thr Pro 
            500                 505                 510         

Ile Thr Ser Val Pro Lys Thr Glu Gly Ala Asp Ile Pro Ile Ile Gly 
        515                 520                 525             

Gly Met Val Ala Ala Trp Ala Asp Thr Pro Ser Ala Arg Tyr Ser Pro 
    530                 535                 540                 

Ser Arg Leu Phe Lys Leu Met Arg His Phe Ala Asn Ala Asn Ala Glu 
545                 550                 555                 560 

Tyr Phe Ala Ala Asp Tyr Glu Ser Ala Glu Gln Ala Leu Asn Glu Val 
                565                 570                 575     

Pro Lys Asp Leu Asn Arg Tyr Thr Ala Glu Ser Val Thr Ala Val Lys 
            580                 585                 590         

Glu Ala Glu Lys Ala Ile Arg Ser Leu Asp Ser Asn Leu Ser Arg Ala 
        595                 600                 605             

Gln Gln Asp Thr Ile Asp Gln Ala Ile Ala Lys Leu Gln Glu Thr Val 
    610                 615                 620                 

Asn Asn Leu Thr Leu Thr Pro Glu Ala Gln Lys Glu Glu Glu Ala Lys 
625                 630                 635                 640 

Arg Glu Val Glu Lys Leu Ala Lys Asn Lys Val Ile Ser Ile Asp Ala 
                645                 650                 655     

Gly Arg Lys Tyr Phe Thr Leu Asn Gln Leu Lys Arg Ile Val Asp Lys 
            660                 665                 670         

Ala Ser Glu Leu Gly Tyr Ser Asp Val His Leu Leu Leu Gly Asn Asp 
        675                 680                 685             

Gly Leu Arg Phe Leu Leu Asp Asp Met Thr Ile Thr Ala Asn Gly Lys 
    690                 695                 700                 

Thr Tyr Ala Ser Asp Asp Val Lys Lys Ala Ile Ile Glu Gly Thr Lys 
705                 710                 715                 720 

Ala Tyr Tyr Asp Asp Pro Asn Gly Thr Ala Leu Thr Gln Ala Glu Val 
                725                 730                 735     

Thr Glu Leu Ile Glu Tyr Ala Lys Ser Lys Asp Ile Gly Leu Ile Pro 
            740                 745                 750         

Ala Ile Asn Ser Pro Gly His Met Asp Ala Met Leu Val Ala Met Glu 
        755                 760                 765             

Lys Leu Gly Ile Lys Asn Pro Gln Ala His Phe Asp Lys Val Ser Lys 
    770                 775                 780                 

Thr Thr Met Asp Leu Lys Asn Glu Glu Ala Met Asn Phe Val Lys Ala 
785                 790                 795                 800 

Leu Ile Gly Lys Tyr Met Asp Phe Phe Ala Gly Lys Thr Lys Ile Phe 
                805                 810                 815     

Asn Phe Gly Thr Asp Glu Tyr Ala Asn Asp Ala Thr Ser Ala Gln Gly 
            820                 825                 830         

Trp Tyr Tyr Leu Lys Trp Tyr Gln Leu Tyr Gly Lys Phe Ala Glu Tyr 
        835                 840                 845             

Ala Asn Thr Leu Ala Ala Met Ala Lys Glu Arg Gly Leu Gln Pro Met 
    850                 855                 860                 

Ala Phe Asn Asp Gly Phe Tyr Tyr Glu Asp Lys Asp Asp Val Gln Phe 
865                 870                 875                 880 

Asp Lys Asp Val Leu Ile Ser Tyr Trp Ser Lys Gly Trp Trp Gly Tyr 
                885                 890                 895     

Asn Leu Ala Ser Pro Gln Tyr Leu Ala Ser Lys Gly Tyr Lys Phe Leu 
            900                 905                 910         

Asn Thr Asn Gly Asp Trp Tyr Tyr Ile Leu Gly Gln Lys Pro Glu Asp 
        915                 920                 925             

Gly Gly Gly Phe Leu Lys Lys Ala Ile Glu Asn Thr Gly Lys Thr Pro 
    930                 935                 940                 

Phe Asn Gln Leu Ala Ser Thr Lys Tyr Pro Glu Val Asp Leu Pro Thr 
945                 950                 955                 960 

Val Gly Ser Met Leu Ser Ile Trp Ala Asp Arg Pro Ser Ala Glu Tyr 
                965                 970                 975     

Lys Glu Glu Glu Ile Phe Glu Leu Met Thr Ala Phe Ala Asp His Asn 
            980                 985                 990         

Lys Asp Tyr Phe Arg Ala Asn Tyr Asn Ala Leu Arg Glu Glu Leu Ala 
        995                 1000                1005            

Lys Ile Pro Thr Asn Leu Glu Gly Tyr Ser Lys Glu Ser Leu Glu Ala 
    1010                1015                1020                

Leu Asp Ala Ala Lys Thr Ala Leu Asn Tyr Asn Leu Asn Arg Asn Lys 
1025                1030                1035                1040

Gln Ala Glu Leu Asp Thr Leu Val Ala Asn Leu Lys Ala Ala Leu Gln 
                1045                1050                1055    

Gly Leu Lys Pro Ala Val Thr His Ser Gly Ser Leu Asp Glu Asn Glu 
            1060                1065                1070        

Val Ala Ala Asn Val Glu Thr Arg Pro Glu Leu Ile Thr Arg Thr Glu 
        1075                1080                1085            

Glu Ile Pro Phe Glu Val Ile Lys Lys Glu Asn Pro Asn Leu Pro Ala 
    1090                1095                1100                

Gly Gln Glu Asn Ile Ile Thr Ala Gly Val Lys Gly Glu Arg Thr His 
1105                1110                1115                1120

Tyr Ile Ser Val Leu Thr Glu Asn Gly Lys Thr Thr Glu Thr Val Leu 
                1125                1130                1135    

Asp Ser Gln Val Thr Lys Glu Val Ile Asn Gln Val Val Glu Val Gly 
            1140                1145                1150        

Ala Pro Val Thr His Lys Gly Asp Glu Ser Gly Leu Ala Pro Thr Thr 
        1155                1160                1165            

Glu Val Lys Pro Arg Leu Asp Ile Gln Glu Glu Glu Ile Pro Phe Thr 
    1170                1175                1180                

Thr Val Thr Cys Glu Asn Pro Leu Leu Leu Lys Gly Lys Thr Gln Val 
1185                1190                1195                1200

Ile Thr Lys Gly Val Asn Gly His Arg Ser Asn Phe Tyr Ser Val Ser 
                1205                1210                1215    

Thr Ser Ala Asp Gly Lys Glu Val Lys Thr Leu Val Asn Ser Val Val 
            1220                1225                1230        

Ala Gln Glu Ala Val Thr Gln Ile Val Glu Val Gly Thr Met Val Thr 
        1235                1240                1245            

His Val Gly Asp Glu Asn Gly Gln Ala Ala Ile Ala Glu Glu Lys Pro 
    1250                1255                1260                

Lys Leu Glu Ile Pro Ser Gln Pro Ala Pro Ser Thr Ala Pro Ala Glu 
1265                1270                1275                1280

Glu Ser Lys Val Leu Pro Gln Asp Pro Ala Pro Val Val Thr Glu Lys 
                1285                1290                1295    

Lys Leu Pro Glu Thr Gly Thr His Asp Ser Ala Gly Leu Val Val Ala 
            1300                1305                1310        

Gly Leu Met Ser Thr Leu Ala Ala Tyr Gly Leu Thr Lys Arg Lys Glu 
        1315                1320                1325            

Asp 
    

<210>   4827
<211>   714
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4827
atggcaattc ccaaatatca atacataaaa gacgaattaa aaaataaaat catctctggg   60
cagtttagca gtggagataa attttacact gaagcagaac tcatttcaat gtacgatgtc   120
agctctatca cagttgttcg cgccttaaac gaccttgcca aagatggcta tattgtccgc   180
caacaaggaa aaggaacctt cgtttcacgt gcacgcaaac acaagcttgt agagttttca   240
gatattgaac tcttcaatgc taaagatgat aaggtaactg ttctttcaat tgaacgcgga   300
aacaagcttg tttacttgga aaaattgggt ctacgcggcg atcaattcta ctacaagatt   360
gaacgtatcc gcgaatcaaa cggtgtcgtt tatatctacc atacatccta catcccagaa   420
caatatatca acgcaaatta tccaaacctt gaatactata gttctatcta taatcgtttc   480
aagttagact accacattca catgaatgat gaacactttg aagaaatcaa cgaaatagtc   540
tttccaactc cagaacatgc agcttcagtc ctcggagtcg atgaacaatt ccctactgtc   600
ctacaaacta aaatcaccaa actcgaatca actggccaag ttttagaata cagtgaaact   660
tacaaacgat ctgattacta caagattaaa tttatctcat gtgaccgtga tcac         714

<210>   4828
<211>   238
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   transcriptional regulator, GntR family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902102 (e-137)

<400>   4828
Met Ala Ile Pro Lys Tyr Gln Tyr Ile Lys Asp Glu Leu Lys Asn Lys 
1               5                   10                  15      

Ile Ile Ser Gly Gln Phe Ser Ser Gly Asp Lys Phe Tyr Thr Glu Ala 
            20                  25                  30          

Glu Leu Ile Ser Met Tyr Asp Val Ser Ser Ile Thr Val Val Arg Ala 
        35                  40                  45              

Leu Asn Asp Leu Ala Lys Asp Gly Tyr Ile Val Arg Gln Gln Gly Lys 
    50                  55                  60                  

Gly Thr Phe Val Ser Arg Ala Arg Lys His Lys Leu Val Glu Phe Ser 
65                  70                  75                  80  

Asp Ile Glu Leu Phe Asn Ala Lys Asp Asp Lys Val Thr Val Leu Ser 
                85                  90                  95      

Ile Glu Arg Gly Asn Lys Leu Val Tyr Leu Glu Lys Leu Gly Leu Arg 
            100                 105                 110         

Gly Asp Gln Phe Tyr Tyr Lys Ile Glu Arg Ile Arg Glu Ser Asn Gly 
        115                 120                 125             

Val Val Tyr Ile Tyr His Thr Ser Tyr Ile Pro Glu Gln Tyr Ile Asn 
    130                 135                 140                 

Ala Asn Tyr Pro Asn Leu Glu Tyr Tyr Ser Ser Ile Tyr Asn Arg Phe 
145                 150                 155                 160 

Lys Leu Asp Tyr His Ile His Met Asn Asp Glu His Phe Glu Glu Ile 
                165                 170                 175     

Asn Glu Ile Val Phe Pro Thr Pro Glu His Ala Ala Ser Val Leu Gly 
            180                 185                 190         

Val Asp Glu Gln Phe Pro Thr Val Leu Gln Thr Lys Ile Thr Lys Leu 
        195                 200                 205             

Glu Ser Thr Gly Gln Val Leu Glu Tyr Ser Glu Thr Tyr Lys Arg Ser 
    210                 215                 220                 

Asp Tyr Tyr Lys Ile Lys Phe Ile Ser Cys Asp Arg Asp His 
225                 230                 235             

<210>   4829
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4829
ttgggaattg ccatattttt acctctattt tccttcttcc atagaaaatt ttaccataaa   60
agcgaaaaaa atagtagtct tttgaataaa aaattagaa                          99

<210>   4830
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4830
Met Gly Ile Ala Ile Phe Leu Pro Leu Phe Ser Phe Phe His Arg Lys 
1               5                   10                  15      

Phe Tyr His Lys Ser Glu Lys Asn Ser Ser Leu Leu Asn Lys Lys Leu 
            20                  25                  30          

Glu 
    

<210>   4831
<211>   1785
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4831
atgacacgat ttgagatacg agatgatttc tatctcgatg gaaaatcatt taagatttta   60
tctggtgcca ttcattattt tagggttcct ccagaggatt ggtatcattc gctctataac   120
ttgaaggctc ttggttttaa tacggtagag acttatgttg cttggaattt acacgagcct   180
tgtgaaggtg agtttcattt tgaaggtgat ctggatttag agaaatttct ccaaatagcg   240
caggatttgg gtctctacgc aattgtgcgt ccgtctccat ttatctgtgc ggaatgggaa   300
ttcggtggct taccagcttg gctcttgacc aagaacatgc gaattcgctc atccgaccca   360
gcatatatcg aggcagttgg tcgctactat gatcagttat tgccaagact ggtgcctcgt   420
ttgttggaca atggtggcaa tattctcatg atgcaggttg aaaatgagta tggttcttac   480
ggagaagata aggcttacct gagagcgatt cgacagctaa tggaagagtg tggcgtaacc   540
tgtcccctct ttacatcaga tggtccatgg cgagctactc tgaaagctgg aaccttaatt   600
gaagaggacc tctttgtaac aggaaacttt ggttctaagg caccttacaa cttttcgcag   660
atgcaggaat tctttgatga acatggtaag aaatggccac tcatgtgtat ggagttctgg   720
gatggttggt tcaatcgctg gaaagaaccg attatcacac gggatcctaa ggaattggca   780
gatgcagttc gagaggtttt ggaacaaggc tctatcaatc tttacatgtt ccacggtggt   840
acaaactttg gtttcatgaa tggttgctca gctcgaggaa ctttggacct gccacaagtt   900
acgtcttatg attacgatgc ccttctggat gaagaaggaa atccaactgc taaatatctt   960
gcagtcaaga agatgatggc aacacatttt tcagagtatc cgcagttgga accactctac   1020
aaagagagta tggagttgga tgctattcca ctagttgaaa aagtttcttt gtttgaaacc   1080
ttagatagct tgtcaagtcc tgtagaaagt ctctatcctc aaaagatgga ggagctggga   1140
caaagttatg gctacctact ttatcgaaca gaaacaaact gggatgcaga agaagaaaga   1200
cttcgtatca ttgatggtcg agatagggcc cagctgtatg tcgatggtca gtgggttaaa   1260
actcaatatc agacagagat tggggaagat attttttatc aaggtaaaaa gaaagggcta   1320
tctaggttag atatcttgat agaaaatatg gggcgtgtca actatgggca taagttctta   1380
gcggatacgc aacgtaaggg aattcggaca ggggtctgta aggatctgca tttcttacta   1440
aactggaaac actatccact cccactagac aatcctgaga aaattgattt ttcaaaagga   1500
tggactcaag gacaaccagc cttttacgct tatgacttta cagtcgaaga gccaaaagat   1560
acttacctag acttgtctga gtttggtaag ggggttgcct ttgtcaatgg gcagaatcta   1620
ggacgttttt ggaacgttgg cccaactctc tcactttata tccctcatag ctatctcaag   1680
gaaggtgcca accgcatcat tatctttgaa acagaaggtc aatataaaga agagattcat   1740
ttaactcgta aacctacact aaaacatata aagggggaaa actta                   1785

<210>   4832
<211>   595
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   beta-galactosidase (bga)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902103 (0.E+01)

<400>   4832
Met Thr Arg Phe Glu Ile Arg Asp Asp Phe Tyr Leu Asp Gly Lys Ser 
1               5                   10                  15      

Phe Lys Ile Leu Ser Gly Ala Ile His Tyr Phe Arg Val Pro Pro Glu 
            20                  25                  30          

Asp Trp Tyr His Ser Leu Tyr Asn Leu Lys Ala Leu Gly Phe Asn Thr 
        35                  40                  45              

Val Glu Thr Tyr Val Ala Trp Asn Leu His Glu Pro Cys Glu Gly Glu 
    50                  55                  60                  

Phe His Phe Glu Gly Asp Leu Asp Leu Glu Lys Phe Leu Gln Ile Ala 
65                  70                  75                  80  

Gln Asp Leu Gly Leu Tyr Ala Ile Val Arg Pro Ser Pro Phe Ile Cys 
                85                  90                  95      

Ala Glu Trp Glu Phe Gly Gly Leu Pro Ala Trp Leu Leu Thr Lys Asn 
            100                 105                 110         

Met Arg Ile Arg Ser Ser Asp Pro Ala Tyr Ile Glu Ala Val Gly Arg 
        115                 120                 125             

Tyr Tyr Asp Gln Leu Leu Pro Arg Leu Val Pro Arg Leu Leu Asp Asn 
    130                 135                 140                 

Gly Gly Asn Ile Leu Met Met Gln Val Glu Asn Glu Tyr Gly Ser Tyr 
145                 150                 155                 160 

Gly Glu Asp Lys Ala Tyr Leu Arg Ala Ile Arg Gln Leu Met Glu Glu 
                165                 170                 175     

Cys Gly Val Thr Cys Pro Leu Phe Thr Ser Asp Gly Pro Trp Arg Ala 
            180                 185                 190         

Thr Leu Lys Ala Gly Thr Leu Ile Glu Glu Asp Leu Phe Val Thr Gly 
        195                 200                 205             

Asn Phe Gly Ser Lys Ala Pro Tyr Asn Phe Ser Gln Met Gln Glu Phe 
    210                 215                 220                 

Phe Asp Glu His Gly Lys Lys Trp Pro Leu Met Cys Met Glu Phe Trp 
225                 230                 235                 240 

Asp Gly Trp Phe Asn Arg Trp Lys Glu Pro Ile Ile Thr Arg Asp Pro 
                245                 250                 255     

Lys Glu Leu Ala Asp Ala Val Arg Glu Val Leu Glu Gln Gly Ser Ile 
            260                 265                 270         

Asn Leu Tyr Met Phe His Gly Gly Thr Asn Phe Gly Phe Met Asn Gly 
        275                 280                 285             

Cys Ser Ala Arg Gly Thr Leu Asp Leu Pro Gln Val Thr Ser Tyr Asp 
    290                 295                 300                 

Tyr Asp Ala Leu Leu Asp Glu Glu Gly Asn Pro Thr Ala Lys Tyr Leu 
305                 310                 315                 320 

Ala Val Lys Lys Met Met Ala Thr His Phe Ser Glu Tyr Pro Gln Leu 
                325                 330                 335     

Glu Pro Leu Tyr Lys Glu Ser Met Glu Leu Asp Ala Ile Pro Leu Val 
            340                 345                 350         

Glu Lys Val Ser Leu Phe Glu Thr Leu Asp Ser Leu Ser Ser Pro Val 
        355                 360                 365             

Glu Ser Leu Tyr Pro Gln Lys Met Glu Glu Leu Gly Gln Ser Tyr Gly 
    370                 375                 380                 

Tyr Leu Leu Tyr Arg Thr Glu Thr Asn Trp Asp Ala Glu Glu Glu Arg 
385                 390                 395                 400 

Leu Arg Ile Ile Asp Gly Arg Asp Arg Ala Gln Leu Tyr Val Asp Gly 
                405                 410                 415     

Gln Trp Val Lys Thr Gln Tyr Gln Thr Glu Ile Gly Glu Asp Ile Phe 
            420                 425                 430         

Tyr Gln Gly Lys Lys Lys Gly Leu Ser Arg Leu Asp Ile Leu Ile Glu 
        435                 440                 445             

Asn Met Gly Arg Val Asn Tyr Gly His Lys Phe Leu Ala Asp Thr Gln 
    450                 455                 460                 

Arg Lys Gly Ile Arg Thr Gly Val Cys Lys Asp Leu His Phe Leu Leu 
465                 470                 475                 480 

Asn Trp Lys His Tyr Pro Leu Pro Leu Asp Asn Pro Glu Lys Ile Asp 
                485                 490                 495     

Phe Ser Lys Gly Trp Thr Gln Gly Gln Pro Ala Phe Tyr Ala Tyr Asp 
            500                 505                 510         

Phe Thr Val Glu Glu Pro Lys Asp Thr Tyr Leu Asp Leu Ser Glu Phe 
        515                 520                 525             

Gly Lys Gly Val Ala Phe Val Asn Gly Gln Asn Leu Gly Arg Phe Trp 
    530                 535                 540                 

Asn Val Gly Pro Thr Leu Ser Leu Tyr Ile Pro His Ser Tyr Leu Lys 
545                 550                 555                 560 

Glu Gly Ala Asn Arg Ile Ile Ile Phe Glu Thr Glu Gly Gln Tyr Lys 
                565                 570                 575     

Glu Glu Ile His Leu Thr Arg Lys Pro Thr Leu Lys His Ile Lys Gly 
            580                 585                 590         

Glu Asn Leu 
        595 

<210>   4833
<211>   474
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4833
atgacaattg taggatgccg tattgatgga cgtttgatcc acggacaagt agccaatctt   60
tgggctggaa aactaaatgt ttcacgcatt atggttgtag acgacgaagt tgtcaacaac   120
gatattgaaa agagtggttt gaaacttgcg acaccaccag gtgtgaaatt gagtattttg   180
ccagttgaga aagctgcagc caatattctt ggtggcaaat acgatagcca acgtctcttt   240
atcgtggctc gtaaaccaga ccgcttcctt ggtttggtag aagcaggtgt accacttgaa   300
acccttaatg ttgggaatat gtctcaaaca ccagaaactc gttctattac acgttctatc   360
aacgtagtag acaaggatgt ggaagacttc cacaaactgg cagaaaaagg tgttaaactt   420
actgctcaga tggttccaaa tgatccaatt tcagactttt tgagcttatt aaaa         474

<210>   4834
<211>   158
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIB component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902104 (1.E-85)

<400>   4834
Met Thr Ile Val Gly Cys Arg Ile Asp Gly Arg Leu Ile His Gly Gln 
1               5                   10                  15      

Val Ala Asn Leu Trp Ala Gly Lys Leu Asn Val Ser Arg Ile Met Val 
            20                  25                  30          

Val Asp Asp Glu Val Val Asn Asn Asp Ile Glu Lys Ser Gly Leu Lys 
        35                  40                  45              

Leu Ala Thr Pro Pro Gly Val Lys Leu Ser Ile Leu Pro Val Glu Lys 
    50                  55                  60                  

Ala Ala Ala Asn Ile Leu Gly Gly Lys Tyr Asp Ser Gln Arg Leu Phe 
65                  70                  75                  80  

Ile Val Ala Arg Lys Pro Asp Arg Phe Leu Gly Leu Val Glu Ala Gly 
                85                  90                  95      

Val Pro Leu Glu Thr Leu Asn Val Gly Asn Met Ser Gln Thr Pro Glu 
            100                 105                 110         

Thr Arg Ser Ile Thr Arg Ser Ile Asn Val Val Asp Lys Asp Val Glu 
        115                 120                 125             

Asp Phe His Lys Leu Ala Glu Lys Gly Val Lys Leu Thr Ala Gln Met 
    130                 135                 140                 

Val Pro Asn Asp Pro Ile Ser Asp Phe Leu Ser Leu Leu Lys 
145                 150                 155             

<210>   4835
<211>   903
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4835
atgatacaat ggtggcaaat tttacttctc actttgtact cagcttatca aatctgtgat   60
gagttgacga tcgtttcatc tgcaggttcc cctgtatttg ctggtttcat tactggttta   120
atcatgggag atgtgactac tggtttactt atcggtggta acttgcaact gttcgttctt   180
ggggttggta ccttcggtgg tgcttctcgt atcgacgcaa cttctggtgc ggttcttgcg   240
acagccttct ctgtttcaca aggaattgat gcaccgcttg ccattactac aatcgctgta   300
ccagtagcag ctctcttgac ttacttcgac gttcttggtc gtatgactac taccttcttc   360
gctcaccgtg tggatgctgc aatcgaacgc tttgactata aaggtattga acgcaactac   420
ttgcttggtg cgattccgtg ggctctatct cgtgcccttc cagtcttctt tgcccttgct   480
tttggtggtg cctttgtaca atcagtagta gacttcgttg aagcctacaa atgggttgca   540
gatggcttga cacttgcagg acgtatgctt ccaggtcttg gatttgcaat cttgcttcgt   600
taccttccag ttaaacgtaa ccttcactac cttgctatgg gatttggttt gacagctatg   660
ttgactgttc tttactcata tgtaacaggt cttggtggcg ctgttgctgg tatcgtaggt   720
actcttcctg ctgaagttgc tgaaaaaatt ggtttcgtga acaacttcaa aggtttgtct   780
atgattggta tttctatcgt aggtattttc cttgcagtgc ttcacttcaa aaatagccaa   840
aaagtagctg tagcagcacc ttctacacca tcagaaagtg gggaaatcga agatgacgaa   900
ttc                                                                 903

<210>   4836
<211>   301
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIC component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902105 (e-169)

<400>   4836
Met Ile Gln Trp Trp Gln Ile Leu Leu Leu Thr Leu Tyr Ser Ala Tyr 
1               5                   10                  15      

Gln Ile Cys Asp Glu Leu Thr Ile Val Ser Ser Ala Gly Ser Pro Val 
            20                  25                  30          

Phe Ala Gly Phe Ile Thr Gly Leu Ile Met Gly Asp Val Thr Thr Gly 
        35                  40                  45              

Leu Leu Ile Gly Gly Asn Leu Gln Leu Phe Val Leu Gly Val Gly Thr 
    50                  55                  60                  

Phe Gly Gly Ala Ser Arg Ile Asp Ala Thr Ser Gly Ala Val Leu Ala 
65                  70                  75                  80  

Thr Ala Phe Ser Val Ser Gln Gly Ile Asp Ala Pro Leu Ala Ile Thr 
                85                  90                  95      

Thr Ile Ala Val Pro Val Ala Ala Leu Leu Thr Tyr Phe Asp Val Leu 
            100                 105                 110         

Gly Arg Met Thr Thr Thr Phe Phe Ala His Arg Val Asp Ala Ala Ile 
        115                 120                 125             

Glu Arg Phe Asp Tyr Lys Gly Ile Glu Arg Asn Tyr Leu Leu Gly Ala 
    130                 135                 140                 

Ile Pro Trp Ala Leu Ser Arg Ala Leu Pro Val Phe Phe Ala Leu Ala 
145                 150                 155                 160 

Phe Gly Gly Ala Phe Val Gln Ser Val Val Asp Phe Val Glu Ala Tyr 
                165                 170                 175     

Lys Trp Val Ala Asp Gly Leu Thr Leu Ala Gly Arg Met Leu Pro Gly 
            180                 185                 190         

Leu Gly Phe Ala Ile Leu Leu Arg Tyr Leu Pro Val Lys Arg Asn Leu 
        195                 200                 205             

His Tyr Leu Ala Met Gly Phe Gly Leu Thr Ala Met Leu Thr Val Leu 
    210                 215                 220                 

Tyr Ser Tyr Val Thr Gly Leu Gly Gly Ala Val Ala Gly Ile Val Gly 
225                 230                 235                 240 

Thr Leu Pro Ala Glu Val Ala Glu Lys Ile Gly Phe Val Asn Asn Phe 
                245                 250                 255     

Lys Gly Leu Ser Met Ile Gly Ile Ser Ile Val Gly Ile Phe Leu Ala 
            260                 265                 270         

Val Leu His Phe Lys Asn Ser Gln Lys Val Ala Val Ala Ala Pro Ser 
        275                 280                 285             

Thr Pro Ser Glu Ser Gly Glu Ile Glu Asp Asp Glu Phe 
    290                 295                 300     

<210>   4837
<211>   828
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4837
gtggggaaat cgaagatgac gaattctaat tacaaactta caaaagaaga ttttaatcaa   60
atcaacaaac gtagcttgtt tactttccaa ttaggttgga actacgaacg tatgcaagct   120
tctggttacc tttacatgat cttgcctcag ttgcgtaaaa tgtatggtga tggaactcct   180
gaattgaaag aaatgatgaa agttcatact caattcttca atacttcacc attcttccat   240
accattatcg ctggttttga ccttgccatg gaagaaaaag atggtgtagg ttcaaaagac   300
gccgttaacg gtatcaagac aggtttgatg ggaccattcg ctcctcttgg ggatacaatc   360
tttggttcac ttgtacctgc tatcatgggg tcagtcgcag caactatggc tatcgctggc   420
caaccttggg ggatcttcct ttggattgca gttgcagtag cgtatgacat cttccgttgg   480
aaacagttgg aatttgctta caaagaaggg gttaacctta tcaacaacat gcaaagtacc   540
ttgacagctt tgattgacgc tgcatctgta cttggtgtct tcatgatggg tgctcttgta   600
gcaacagtga ttaactttga aatttcttac aagttgccaa tcggtgaaaa gatgattgat   660
ttccaagaca tcttgaacca aatcttccca cgtttgcttc cagcaatctt tactgccttt   720
atcttctggt tgcttggtaa gaaaggtatg aactctacta aagctatcgg tattattatc   780
gtacttgctt tggctctttc tgcccttggt cactttgcac ttggaatg                828

<210>   4838
<211>   276
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IID component
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902106 (e-155)

<400>   4838
Met Gly Lys Ser Lys Met Thr Asn Ser Asn Tyr Lys Leu Thr Lys Glu 
1               5                   10                  15      

Asp Phe Asn Gln Ile Asn Lys Arg Ser Leu Phe Thr Phe Gln Leu Gly 
            20                  25                  30          

Trp Asn Tyr Glu Arg Met Gln Ala Ser Gly Tyr Leu Tyr Met Ile Leu 
        35                  40                  45              

Pro Gln Leu Arg Lys Met Tyr Gly Asp Gly Thr Pro Glu Leu Lys Glu 
    50                  55                  60                  

Met Met Lys Val His Thr Gln Phe Phe Asn Thr Ser Pro Phe Phe His 
65                  70                  75                  80  

Thr Ile Ile Ala Gly Phe Asp Leu Ala Met Glu Glu Lys Asp Gly Val 
                85                  90                  95      

Gly Ser Lys Asp Ala Val Asn Gly Ile Lys Thr Gly Leu Met Gly Pro 
            100                 105                 110         

Phe Ala Pro Leu Gly Asp Thr Ile Phe Gly Ser Leu Val Pro Ala Ile 
        115                 120                 125             

Met Gly Ser Val Ala Ala Thr Met Ala Ile Ala Gly Gln Pro Trp Gly 
    130                 135                 140                 

Ile Phe Leu Trp Ile Ala Val Ala Val Ala Tyr Asp Ile Phe Arg Trp 
145                 150                 155                 160 

Lys Gln Leu Glu Phe Ala Tyr Lys Glu Gly Val Asn Leu Ile Asn Asn 
                165                 170                 175     

Met Gln Ser Thr Leu Thr Ala Leu Ile Asp Ala Ala Ser Val Leu Gly 
            180                 185                 190         

Val Phe Met Met Gly Ala Leu Val Ala Thr Val Ile Asn Phe Glu Ile 
        195                 200                 205             

Ser Tyr Lys Leu Pro Ile Gly Glu Lys Met Ile Asp Phe Gln Asp Ile 
    210                 215                 220                 

Leu Asn Gln Ile Phe Pro Arg Leu Leu Pro Ala Ile Phe Thr Ala Phe 
225                 230                 235                 240 

Ile Phe Trp Leu Leu Gly Lys Lys Gly Met Asn Ser Thr Lys Ala Ile 
                245                 250                 255     

Gly Ile Ile Ile Val Leu Ala Leu Ala Leu Ser Ala Leu Gly His Phe 
            260                 265                 270         

Ala Leu Gly Met 
        275     

<210>   4839
<211>   402
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4839
atgactaaat cattaatttt ggtgagccat ggtcgcttct gtgaggagct tagaggtagc   60
acagaaatga ttatgggccc acaagacaac atttacacag tagctcttct tccagaagat   120
ggcccagaag aatttactgc taaatttgaa gctgttattg aaggattgga tgatttccta   180
gtctttgcgg atcttctcgg tgggacacct tgtaatgtgg tgagtcgctt gatcatggaa   240
ggtcgtgata ttgaccttta cgcagggatg aatcttccaa tggtgattga atttatcaat   300
gcgagcctta caggcgcaga tgcggactac aagagccgtg ctgcagaaag cattgtgaaa   360
gttaatgacc tgttagcggg cttcgatgat gacgaagatg aa                      402

<210>   4840
<211>   134
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   PTS system, IIA component
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902107 (1.E-73)

<400>   4840
Met Thr Lys Ser Leu Ile Leu Val Ser His Gly Arg Phe Cys Glu Glu 
1               5                   10                  15      

Leu Arg Gly Ser Thr Glu Met Ile Met Gly Pro Gln Asp Asn Ile Tyr 
            20                  25                  30          

Thr Val Ala Leu Leu Pro Glu Asp Gly Pro Glu Glu Phe Thr Ala Lys 
        35                  40                  45              

Phe Glu Ala Val Ile Glu Gly Leu Asp Asp Phe Leu Val Phe Ala Asp 
    50                  55                  60                  

Leu Leu Gly Gly Thr Pro Cys Asn Val Val Ser Arg Leu Ile Met Glu 
65                  70                  75                  80  

Gly Arg Asp Ile Asp Leu Tyr Ala Gly Met Asn Leu Pro Met Val Ile 
                85                  90                  95      

Glu Phe Ile Asn Ala Ser Leu Thr Gly Ala Asp Ala Asp Tyr Lys Ser 
            100                 105                 110         

Arg Ala Ala Glu Ser Ile Val Lys Val Asn Asp Leu Leu Ala Gly Phe 
        115                 120                 125             

Asp Asp Asp Glu Asp Glu 
    130                 

<210>   4841
<211>   1164
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4841
atgctacatt atacaaaaga agacttgctc gaattgggtg cagaaatcac tacgcgtgaa   60
atctaccaac agcctgatgt atggagagaa gcttttgaat tttatcaagc aaaacgtgaa   120
gaaattgcag ccttcctaca agaaatcgct gataaacatg actatattaa ggttatcttg   180
acaggtgctg ggacttctgc ttatgtggga gataccttgc taccttattt taaggaagtc   240
tatgacgaac gcaaatggaa tttcaatgct attgcgacaa cagatatcgt tgccaatcca   300
gcaacctatt tgaaaaaaga tgtggcaact gtccttgtgt cttttgctcg tagtgggaat   360
tcgcctgaaa gtttggcgac tgttgatttg gccaaatcct tggtggatga gctttatcaa   420
gtgacgatta cttgtgcagc agatggtaaa ttggctcttc aagctcacgg tgatgatcgt   480
aatctcttgc tcttgcaacc agctgtctct aatgatgctg gatttgccat gacttctagc   540
tttacgtcta tgatgttgac aactctcttg gtctttgatc ctacagaatt tgctgttaag   600
tctgaacgtt ttgaagttgt atctagtctt gcccgtaaag ttttagacaa ggcagaagat   660
gtcaaagagc tcgttgattt agactttaac cgtgtcatct atctaggcgc tggtcctttc   720
tttggacttg ctcatgaagc tcagctcaag attttggaat taactgctgg tcaagttgcg   780
accatgtatg aaagcccagt tggcttccgt cacggtccaa aatctcttat caacgacaat   840
acagttgttt tggtctttgg tacaacgaca gactacactc gtaagtacga cttggacttg   900
gttcgtgaag ttgctggtga ccagattgct cgtcgtgttg tgcttttgag tgatcaagct   960
tttggtcttg aaaatgtcaa agaagtggcc cttggttgtg gcggtgtctt gaatgatatt   1020
taccgtgtct tcccttacat cgtttatgcc caactctttg ctttattgac ttcactcaag   1080
gtagaaaata aaccagatac accgtctcct acaggtacag taaaccgtgt agtacaaggt   1140
gtcataattc acgaatatca aaag                                          1164

<210>   4842
<211>   388
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sugar isomerase domain protein AgaS (agaS)
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902108 (0.E+01)

<400>   4842
Met Leu His Tyr Thr Lys Glu Asp Leu Leu Glu Leu Gly Ala Glu Ile 
1               5                   10                  15      

Thr Thr Arg Glu Ile Tyr Gln Gln Pro Asp Val Trp Arg Glu Ala Phe 
            20                  25                  30          

Glu Phe Tyr Gln Ala Lys Arg Glu Glu Ile Ala Ala Phe Leu Gln Glu 
        35                  40                  45              

Ile Ala Asp Lys His Asp Tyr Ile Lys Val Ile Leu Thr Gly Ala Gly 
    50                  55                  60                  

Thr Ser Ala Tyr Val Gly Asp Thr Leu Leu Pro Tyr Phe Lys Glu Val 
65                  70                  75                  80  

Tyr Asp Glu Arg Lys Trp Asn Phe Asn Ala Ile Ala Thr Thr Asp Ile 
                85                  90                  95      

Val Ala Asn Pro Ala Thr Tyr Leu Lys Lys Asp Val Ala Thr Val Leu 
            100                 105                 110         

Val Ser Phe Ala Arg Ser Gly Asn Ser Pro Glu Ser Leu Ala Thr Val 
        115                 120                 125             

Asp Leu Ala Lys Ser Leu Val Asp Glu Leu Tyr Gln Val Thr Ile Thr 
    130                 135                 140                 

Cys Ala Ala Asp Gly Lys Leu Ala Leu Gln Ala His Gly Asp Asp Arg 
145                 150                 155                 160 

Asn Leu Leu Leu Leu Gln Pro Ala Val Ser Asn Asp Ala Gly Phe Ala 
                165                 170                 175     

Met Thr Ser Ser Phe Thr Ser Met Met Leu Thr Thr Leu Leu Val Phe 
            180                 185                 190         

Asp Pro Thr Glu Phe Ala Val Lys Ser Glu Arg Phe Glu Val Val Ser 
        195                 200                 205             

Ser Leu Ala Arg Lys Val Leu Asp Lys Ala Glu Asp Val Lys Glu Leu 
    210                 215                 220                 

Val Asp Leu Asp Phe Asn Arg Val Ile Tyr Leu Gly Ala Gly Pro Phe 
225                 230                 235                 240 

Phe Gly Leu Ala His Glu Ala Gln Leu Lys Ile Leu Glu Leu Thr Ala 
                245                 250                 255     

Gly Gln Val Ala Thr Met Tyr Glu Ser Pro Val Gly Phe Arg His Gly 
            260                 265                 270         

Pro Lys Ser Leu Ile Asn Asp Asn Thr Val Val Leu Val Phe Gly Thr 
        275                 280                 285             

Thr Thr Asp Tyr Thr Arg Lys Tyr Asp Leu Asp Leu Val Arg Glu Val 
    290                 295                 300                 

Ala Gly Asp Gln Ile Ala Arg Arg Val Val Leu Leu Ser Asp Gln Ala 
305                 310                 315                 320 

Phe Gly Leu Glu Asn Val Lys Glu Val Ala Leu Gly Cys Gly Gly Val 
                325                 330                 335     

Leu Asn Asp Ile Tyr Arg Val Phe Pro Tyr Ile Val Tyr Ala Gln Leu 
            340                 345                 350         

Phe Ala Leu Leu Thr Ser Leu Lys Val Glu Asn Lys Pro Asp Thr Pro 
        355                 360                 365             

Ser Pro Thr Gly Thr Val Asn Arg Val Val Gln Gly Val Ile Ile His 
    370                 375                 380                 

Glu Tyr Gln Lys 
385             

<210>   4843
<211>   1035
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4843
atgaaagcat acacagagcg tgtatttgga aatgttgagg gtgaggatgt cttggcctat   60
cgatttgaga cagacggtgg ctaccaactt gaggttatga cttatggtgc gactatcttg   120
cgctatgtcg cacctgacaa ggctggaaat tttgccaatg ttatcttggg atttgatgac   180
tttgatagtt atgtaggcaa tagtcccaag catggagcaa gtgtaggtcc tgtagcgggt   240
cgtattgcag gtgcgacctt tgagctcaat ggtaagacct atgaccttga ggttaataat   300
gctagcaact gtaatcacag tggttcaact ggttgggatt ccagcttgtt tgaagttgaa   360
gaagtaagcg atcatggctt gactctctac acagagcgta cagatgggac aggagggttc   420
cctggaaatc tcaagatttg gatcagttat cacttggaag aaactggtgc ctatgaaatc   480
agctacaagg taacgaccga tcaggatacg ctggtcaatc caaccaacca cagctatttc   540
aacttgtctg gtgatttcac gcagacgatt gaccgtcatg tcttccaact aaacacagag   600
ggcatttact caatcgctcc tgacggtgtt cctgccaaaa ctccagaagc caaccgtgat   660
gtggtcaaac acgtctacaa tggtaccttg ttgaaggata tctttgcaga agaagatgag   720
caaatccagc tggcatcagg tttggatcat ccatttgccc ttcctgcagg ccatgacaat   780
gctggattcc tttatgacca aaattcaggt cgcttcctgc ttttcaagac agaagctcct   840
tgctttgtgg tctacacagc aaactttgtg gatgaaagtg tcatcatagg aggtcagcca   900
atgctacagc acaatgggat tgctcttgaa gcgcaagctt taccagatgc cattcacagt   960
gaccttaaag gccaagtcat tcttaaagct ggtcaaacct tcaccagtaa gacacgttat   1020
gaacttgttg tgaag                                                    1035

<210>   4844
<211>   345
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   aldose 1-epimerase (galM)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902109 (0.E+01)

<400>   4844
Met Lys Ala Tyr Thr Glu Arg Val Phe Gly Asn Val Glu Gly Glu Asp 
1               5                   10                  15      

Val Leu Ala Tyr Arg Phe Glu Thr Asp Gly Gly Tyr Gln Leu Glu Val 
            20                  25                  30          

Met Thr Tyr Gly Ala Thr Ile Leu Arg Tyr Val Ala Pro Asp Lys Ala 
        35                  40                  45              

Gly Asn Phe Ala Asn Val Ile Leu Gly Phe Asp Asp Phe Asp Ser Tyr 
    50                  55                  60                  

Val Gly Asn Ser Pro Lys His Gly Ala Ser Val Gly Pro Val Ala Gly 
65                  70                  75                  80  

Arg Ile Ala Gly Ala Thr Phe Glu Leu Asn Gly Lys Thr Tyr Asp Leu 
                85                  90                  95      

Glu Val Asn Asn Ala Ser Asn Cys Asn His Ser Gly Ser Thr Gly Trp 
            100                 105                 110         

Asp Ser Ser Leu Phe Glu Val Glu Glu Val Ser Asp His Gly Leu Thr 
        115                 120                 125             

Leu Tyr Thr Glu Arg Thr Asp Gly Thr Gly Gly Phe Pro Gly Asn Leu 
    130                 135                 140                 

Lys Ile Trp Ile Ser Tyr His Leu Glu Glu Thr Gly Ala Tyr Glu Ile 
145                 150                 155                 160 

Ser Tyr Lys Val Thr Thr Asp Gln Asp Thr Leu Val Asn Pro Thr Asn 
                165                 170                 175     

His Ser Tyr Phe Asn Leu Ser Gly Asp Phe Thr Gln Thr Ile Asp Arg 
            180                 185                 190         

His Val Phe Gln Leu Asn Thr Glu Gly Ile Tyr Ser Ile Ala Pro Asp 
        195                 200                 205             

Gly Val Pro Ala Lys Thr Pro Glu Ala Asn Arg Asp Val Val Lys His 
    210                 215                 220                 

Val Tyr Asn Gly Thr Leu Leu Lys Asp Ile Phe Ala Glu Glu Asp Glu 
225                 230                 235                 240 

Gln Ile Gln Leu Ala Ser Gly Leu Asp His Pro Phe Ala Leu Pro Ala 
                245                 250                 255     

Gly His Asp Asn Ala Gly Phe Leu Tyr Asp Gln Asn Ser Gly Arg Phe 
            260                 265                 270         

Leu Leu Phe Lys Thr Glu Ala Pro Cys Phe Val Val Tyr Thr Ala Asn 
        275                 280                 285             

Phe Val Asp Glu Ser Val Ile Ile Gly Gly Gln Pro Met Leu Gln His 
    290                 295                 300                 

Asn Gly Ile Ala Leu Glu Ala Gln Ala Leu Pro Asp Ala Ile His Ser 
305                 310                 315                 320 

Asp Leu Lys Gly Gln Val Ile Leu Lys Ala Gly Gln Thr Phe Thr Ser 
                325                 330                 335     

Lys Thr Arg Tyr Glu Leu Val Val Lys 
            340                 345 

<210>   4845
<211>   258
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4845
ttggctttga ccttggctgg agcagttttg acaaatgatg tttttgcgaa cgacagactt   60
gtggcaacac aaactactga tggtaaaaat gaaaatgtat tgacctcaga ggtgctaaaa   120
ccttctagtg gcaatgtttt ggttggaatc aaaggagaat ttgtggctcc tcatcaacaa   180
tctattttgg atgccatcaa tgctatctgt aaagaagcgg ctgacgaagg tttggtagat   240
aagtatgtcc ctatcaaa                                                 258

<210>   4846
<211>   86
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside

<400>   4846
Met Ala Leu Thr Leu Ala Gly Ala Val Leu Thr Asn Asp Val Phe Ala 
1               5                   10                  15      

Asn Asp Arg Leu Val Ala Thr Gln Thr Thr Asp Gly Lys Asn Glu Asn 
            20                  25                  30          

Val Leu Thr Ser Glu Val Leu Lys Pro Ser Ser Gly Asn Val Leu Val 
        35                  40                  45              

Gly Ile Lys Gly Glu Phe Val Ala Pro His Gln Gln Ser Ile Leu Asp 
    50                  55                  60                  

Ala Ile Asn Ala Ile Cys Lys Glu Ala Ala Asp Glu Gly Leu Val Asp 
65                  70                  75                  80  

Lys Tyr Val Pro Ile Lys 
                85      

<210>   4847
<211>   195
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4847
atggatcata cccgtctttc tagcaaagat ctttggagtg cctttccaac ttctaatagt   60
ataatgggag aaaatttggc atggaatcat gacggttttc taaaagctat tgaacaatgg   120
cgtgctgaaa aagcagatta tgtggagaaa aaaatagtgg ttcagacaac gggaaatctg   180
gtcactatga gtcgc                                                    195

<210>   4848
<211>   65

<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4848
Met Asp His Thr Arg Leu Ser Ser Lys Asp Leu Trp Ser Ala Phe Pro 
1               5                   10                  15      

Thr Ser Asn Ser Ile Met Gly Glu Asn Leu Ala Trp Asn His Asp Gly 
            20                  25                  30          

Phe Leu Lys Ala Ile Glu Gln Trp Arg Ala Glu Lys Ala Asp Tyr Val 
        35                  40                  45              

Glu Lys Lys Ile Val Val Gln Thr Thr Gly Asn Leu Val Thr Met Ser 
    50                  55                  60                  

Arg 
65  

<210>   4849
<211>   633
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4849
atggggatgg cagcttttaa aaatcctaac aatcaataca aagctattac aattgctcaa   60
actctaggtg atgatgcttc ttcagaggaa ttggctggta gatatggttc tgctgttcag   120
tgtacagaag tgactgcctc aaacctttca acagttaaaa ctaaagctac ggttgtagaa   180
aaaccactga aagattttag agcgtctacg tctgatcagt ctggttgggt ggaatctaat   240
ggtaaatggt atttctatga gtctggtgat gtgaagacag gttgggtgaa aacagatggt   300
aaatggtact atttgaatga cttaggtgtc atgcagactg gatttgtaaa attttctggt   360
agctggtatt acttgagcaa ttcaggtgct atgtttacag gctggggaac agatggtagc   420
agatggttct actttgacgg ctcaggagct atgaagacag gctggtacaa ggaaaatggc   480
acttggtatt accttgacga agcaggtatc atgaagacag gttggtttaa agtcggacca   540
cactggtact atgcctacgg ttcaggagct ttggctgtga gcacaacaac accagatggt   600
taccgtgtaa atggtaatgg tgaatgggta aac                                633

<210>   4850
<211>   211
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   choline binding protein I (cbpI)
<223>   Cellular location: cytoplasm
<223>   Feature of note: WYY motif
<223>   Similar to strain R6 sequence 15903986 (7.E-51)

<400>   4850
Met Gly Met Ala Ala Phe Lys Asn Pro Asn Asn Gln Tyr Lys Ala Ile 
1               5                   10                  15      

Thr Ile Ala Gln Thr Leu Gly Asp Asp Ala Ser Ser Glu Glu Leu Ala 
            20                  25                  30          

Gly Arg Tyr Gly Ser Ala Val Gln Cys Thr Glu Val Thr Ala Ser Asn 
        35                  40                  45              

Leu Ser Thr Val Lys Thr Lys Ala Thr Val Val Glu Lys Pro Leu Lys 
    50                  55                  60                  

Asp Phe Arg Ala Ser Thr Ser Asp Gln Ser Gly Trp Val Glu Ser Asn 
65                  70                  75                  80  

Gly Lys Trp Tyr Phe Tyr Glu Ser Gly Asp Val Lys Thr Gly Trp Val 
                85                  90                  95      

Lys Thr Asp Gly Lys Trp Tyr Tyr Leu Asn Asp Leu Gly Val Met Gln 
            100                 105                 110         

Thr Gly Phe Val Lys Phe Ser Gly Ser Trp Tyr Tyr Leu Ser Asn Ser 
        115                 120                 125             

Gly Ala Met Phe Thr Gly Trp Gly Thr Asp Gly Ser Arg Trp Phe Tyr 
    130                 135                 140                 

Phe Asp Gly Ser Gly Ala Met Lys Thr Gly Trp Tyr Lys Glu Asn Gly 
145                 150                 155                 160 

Thr Trp Tyr Tyr Leu Asp Glu Ala Gly Ile Met Lys Thr Gly Trp Phe 
                165                 170                 175     

Lys Val Gly Pro His Trp Tyr Tyr Ala Tyr Gly Ser Gly Ala Leu Ala 
            180                 185                 190         

Val Ser Thr Thr Thr Pro Asp Gly Tyr Arg Val Asn Gly Asn Gly Glu 
        195                 200                 205             

Trp Val Asn 
    210     

<210>   4851
<211>   114
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4851
ttgaggcgac aagaatccaa tctttataaa tcaaaagagg ccaatgttcg ccatcaacct   60
ctttcttatc gttcattctt tttgctaagt aagatgaatg ctttacctat ggcc         114

<210>   4852
<211>   38
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4852
Met Arg Arg Gln Glu Ser Asn Leu Tyr Lys Ser Lys Glu Ala Asn Val 
1               5                   10                  15      

Arg His Gln Pro Leu Ser Tyr Arg Ser Phe Phe Leu Leu Ser Lys Met 
            20                  25                  30          

Asn Ala Leu Pro Met Ala 
        35              

<210>   4853
<211>   99
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4853
atgaacgata agaaagaggt tgatggcgaa cattggcctc ttttgattta taaagattgg   60
attcttgtcg cctcaatttc agacttttct attgtaagc                          99

<210>   4854
<211>   33
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4854
Met Asn Asp Lys Lys Glu Val Asp Gly Glu His Trp Pro Leu Leu Ile 
1               5                   10                  15      

Tyr Lys Asp Trp Ile Leu Val Ala Ser Ile Ser Asp Phe Ser Ile Val 
            20                  25                  30          

Ser 
    

<210>   4855
<211>   5568
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4855
atgagccgaa aaagcattgg tgagaaacgc catagtttct cgatgagaaa gttgtcagtg   60
ggattggtat cagttactgt atctagtttc tttttgatga gtcaagggat tcaatcggta   120
tcggccgata atatggaaag tccaattcat tataagtata tgaccgaggg taaattgaca   180
gacgaggaaa aatccttgct ggtagaggcc cttccacaac tggctgaaga atcagatgat   240
acttattact tggtttatag atctcaacag tttttaccga atacaggttt taacccaact   300
gttggtactt tcctttttac tgcaggattg agcttgttag ttttattggt ttctaaaagg   360
gaaaatggaa agaaacgact tgttcatttt ctgctgttga ctagcatggg agttcaattg   420
ttgccggcca gtgcttttgg gttgaccagc cagattttat ctgcctataa tagtcagctt   480
tctatcggag tcggggaaca tttaccagag cctctgaaaa tcgaaggtta tcaatatatt   540
ggttatatca aaactaagaa acaggataat acagagcttt caaggacagt tgatgggaaa   600
tactctgctc aaagagatag tcaaccaaac tctacaaaaa catcagatgt agttcattca   660
gctgatttag aatggaacca aggacagggg aaggttagtt tacaaggtga agcatcaggg   720
gatgatggac tttcagaaaa atcttctata gcagcagaca atctatcttc taatgattca   780
ttcgcaagtc aagttgagca gaatccggat cacaaaggag aatctgtagt tcgaccaaca   840
gtgccagaac aaggaaatcc tgtgtctgct acaacggtgc agagtgcgga agaggaagta   900
ttggcgacga caaatgatcg accagagtat aaacttccat tggaaaccaa aggcacgcaa   960
gaacccggtc atgagggtga agccgcagtc cgtgaagact taccagtcta cactaagcca   1020
ctagaaacca aaggtacaca aggacccgga catgaaggtg aagctgcagt tcgcgaggaa   1080
gaaccagctt acacagaacc gttagcaacg aaaggcacgc aagagccagg tcatgagggc   1140
aaagctacag tccgcgaaga gactctagag tacacggaac cggtagcgac aaaaggcaca   1200
caagaacccg aacatgaggg cgaagcggca gtagaagaag aacttccggc tttagaggtc   1260
actacacgaa atagaacgga aatccagaat attccttata caacagaaga aattcaggat   1320
ccaacacttc tgaaaaatcg tcgtaagatt gaacgacaag ggcaagcagg gacacgtaca   1380
attcaatatg aagactacat cgtaaatggt aatgtcgtag aaactaaaga agtgtcacga   1440
actgaagtag ctccggtcaa cgaagtcgtt aaagtaggaa cacttgtgaa agttaaacct   1500
acagtagaaa ttacaaactt aacaaaagtt gagaacaaaa aatctataac tgtaagttat   1560
aacttaatag acactacctc agcatatgtt tctgcaaaaa cgcaagtttt ccatggagac   1620
aagctagtta aagaggtgga tatagaaaat cctgccaaag agcaagtaat atcaggttta   1680
gattactaca caccgtatac agttaaaaca cacctaactt ataatttggg tgaaaataat   1740
gaggaaaata ctgaaacatc aactcaagat ttccaattag agtataagaa aatagagatt   1800
aaagatattg attcagtaga attatacggt aaagaaaatg atcgttatcg tagatattta   1860
agtctaagtg aagcgccgac tgatacggct aaatactttg taaaagtgaa atcagatcgc   1920
ttcaaagaaa tgtacctacc tgtaaaatct attacagaaa atacggatgg aacgtataaa   1980
gtgacggtag ccgttgatca acttgtcgaa gaaggtacag acggttacaa agatgattac   2040
acatttactg tagctaaatc taaagcagag caaccaggag tttacacatc ctttaaacag   2100
ctggtaacag ccatgcaaag caatctgtct ggtgtctata cattggcttc agatatgacc   2160
gcagatgagg tgagcttagg cgataagcag acaagttatc tcacaggtgc atttacaggg   2220
agcttgatcg gttctgatgg aacaaaatcg tatgccattt atgatttgaa gaaaccatta   2280
tttgatacat taaatggtgc tacagttaga gatttggata ttaaaactgt ttctgctgat   2340
agtaaagaaa atgtcgcagc gctggcgaag gcagcgaata gcgcgaatat taataatgtt   2400
gcagtagaag gaaaaatctc aggtgcgaaa tctgttgcgg gattagtagc gagcgcaaca   2460
aatacagtga tagaaaacag ctcgtttaca gggaaactta tcgcaaatca ccaggacagt   2520
aataaaaatg atactggagg aatagtaggt aatataacag gaaatagttc gagagttaat   2580
aaagttaggg tagatgcctt aatctctact aatgcacgca ataataacca aacagctgga   2640
gggatagtag gtagattaga aaatggtgca ttgatatcta attcggttgc tactggagaa   2700
atacgaaatg gtcaaggata ttctagagtc ggaggaatag taggatctac gtggcaaaac   2760
ggtcgagtaa ataatgttgt gagtaacgta gatgttggag atggttatgt tatcaccggt   2820
gatcaatacg cagcagcaga tgtgaaaaat gcaagtacat cagttgataa tagaaaagca   2880
gacagattcg ctacaaaatt atcaaaagac caaatagacg cgaaagttgc tgattatgga   2940
atcacagtaa ctcttgatga tactgggcaa gatttaaaac gtaatctaag agaagttgat   3000
tatacaagac taaataaagc agaagctgaa agaaaagtag cttatagcaa catagaaaaa   3060
ctgatgccat tctacaataa agacctagta gttcactatg gtaacaaagt agcgacaaca   3120
gataaacttt acactacaga attgttagat gttgtgccga tgaaagatga tgaagtagta   3180
acggatatta ataataagaa aaattcaata aataaagtta tgttacattt caaagataat   3240
acagtagaat acctagatgt aacattcaaa gaaaacttca taaacagtca agtaatcgaa   3300
tacaatgtta caggaaaaga atatatattc acaccagaag catttgtttc agactataca   3360
gcgataacga ataacgtact aagcgacttg caaaatgtaa cacttaactc agaagctact   3420
aaaaaagtac taggagcagc gaatgatgca gccttagata acctatactt agatagacaa   3480
tttgaagaag ttaaagctaa tatagcagaa cacctaagaa aagtattagc gatggataaa   3540
tcaatcaata ctacaggaga cggtgtagtt gaatacgtaa gtgagaaaat caaaaataac   3600
aaagaagcat ttatgctagg tcttacttat atgaaccgtt ggtacgatat taattatggt   3660
aaaatgaata caaaagattt atctacgtac aagtttgact ttaacggaaa taatgagact   3720
tcaacgttgg atactattgt cgcattagga aatagtggac tagataacct gagagcttca   3780
aatactgtag gtttatatgc gaataaactt gcatcggtaa aaggagaaga ttcagtcttt   3840
gacttcgtag aagcgtatag aaaactgttc ttaccaaaca aaacaaataa cgagtggttt   3900
aaagaaaata caaaggcata tatagtcgaa atgaagtctg atattgcaga agtacgagaa   3960
aaacaagaat caccaacagc cgatagaaaa tattcattag gagtttacga tagaatatca   4020
gcaccaagtt gggggcataa gagtatgtta ttaccactac taactttacc tgaagaatct   4080
gtgtatattt catcgaatat gtctacactt gcattcggtt cgtatgaaag atatcgtgat   4140
agtgtggatg gagttattct ttcaggagat gctttacgaa cttatgtaag aaatagagtt   4200
gatatagcag cgaaaaggca tagagaccat tatgatattt ggtacaatct tcttgacagt   4260
gcttcaaaag aaaaactttt ccgttctgtg atagtttatg atggattcaa tgtaaaagat   4320
gagacaggaa gaacttattg ggcaaggtta acggataaaa acatcggctc tattaaagaa   4380
ttcttcggac ctgttgggaa atggtatgag tataatagta gtgcaggagc gtatgcgaat   4440
ggaagtttaa cgcactttgt gttagataga ttattagatg cttatggaac gtcggtttat   4500
actcatgaaa tggttcataa ttctgattct gcaatctact ttgaaggaaa tggtagacgt   4560
gaaggattgg gagcggagtt atacgcactt ggtttactgc aatctgtaga tagtgtaaat   4620
tctcatattt tagctttaaa tacgttatat aaagcagaaa aagatgattt gaatagattg   4680
catacatata atccggtgga acgtttcgat tcggatgagg cgcttcaaag ttatatgcat   4740
ggatcatatg atgtaatgta tacacttgat gcgatggaag caaaagcgat attagctcaa   4800
aataatgatg ttaagaaaaa atggtttaga aaaatagaaa attattacgt tcgtgatact   4860
agacataata aagatacaca tgcaggaaat aaagtccgtc cattaacaga tgaagaagta   4920
gctaacttaa catcgttaaa ctcattaatc gacaacgaca tcataaatag acgtagctat   4980
gatgatagta gagaatataa acgaaatggc tactatacta taagtatgtt ctctcctgta   5040
tacgcagcgc taagcaattc gaaaggtgct cctggagata ttatgtttag aaaaatagct   5100
tatgaattac ttgcggaaaa aggttatcac aaaggattcc taccttatgt ttctaatcag   5160
tacggagcag aagcatttgc cagcggaagc aaaacattct catcatggca tggaagagat   5220
gttgctttag tgacagatga tttagtattt aagaaagtat tcaatggtga gtactcatca   5280
tgggctgatt tcaaaaaagc aatgtttaaa caacgtatag ataaacaaga taatctgaaa   5340
ccaataacaa ttcaatacga attaggtaat cctaatagta caaaagaagt aactataaca   5400
acggctgcac aaatgcaaca attaattaat gaagcggctg cgaaagatat tactaatata   5460
gatcgtgcaa cgagtcatac cccagcaagt tgggtgcatt tattaaaaca aaaaatctat   5520
aatgcatatc ttcgcactac agatgacttt agaaattcta tatataaa                5568

<210>   4856
<211>   1856
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   immunoglobulin A1 protease (iga)
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15903086 (0.E+01)

<400>   4856
Met Ser Arg Lys Ser Ile Gly Glu Lys Arg His Ser Phe Ser Met Arg 
1               5                   10                  15      

Lys Leu Ser Val Gly Leu Val Ser Val Thr Val Ser Ser Phe Phe Leu 
            20                  25                  30          

Met Ser Gln Gly Ile Gln Ser Val Ser Ala Asp Asn Met Glu Ser Pro 
        35                  40                  45              

Ile His Tyr Lys Tyr Met Thr Glu Gly Lys Leu Thr Asp Glu Glu Lys 
    50                  55                  60                  

Ser Leu Leu Val Glu Ala Leu Pro Gln Leu Ala Glu Glu Ser Asp Asp 
65                  70                  75                  80  

Thr Tyr Tyr Leu Val Tyr Arg Ser Gln Gln Phe Leu Pro Asn Thr Gly 
                85                  90                  95      

Phe Asn Pro Thr Val Gly Thr Phe Leu Phe Thr Ala Gly Leu Ser Leu 
            100                 105                 110         

Leu Val Leu Leu Val Ser Lys Arg Glu Asn Gly Lys Lys Arg Leu Val 
        115                 120                 125             

His Phe Leu Leu Leu Thr Ser Met Gly Val Gln Leu Leu Pro Ala Ser 
    130                 135                 140                 

Ala Phe Gly Leu Thr Ser Gln Ile Leu Ser Ala Tyr Asn Ser Gln Leu 
145                 150                 155                 160 

Ser Ile Gly Val Gly Glu His Leu Pro Glu Pro Leu Lys Ile Glu Gly 
                165                 170                 175     

Tyr Gln Tyr Ile Gly Tyr Ile Lys Thr Lys Lys Gln Asp Asn Thr Glu 
            180                 185                 190         

Leu Ser Arg Thr Val Asp Gly Lys Tyr Ser Ala Gln Arg Asp Ser Gln 
        195                 200                 205             

Pro Asn Ser Thr Lys Thr Ser Asp Val Val His Ser Ala Asp Leu Glu 
    210                 215                 220                 

Trp Asn Gln Gly Gln Gly Lys Val Ser Leu Gln Gly Glu Ala Ser Gly 
225                 230                 235                 240 

Asp Asp Gly Leu Ser Glu Lys Ser Ser Ile Ala Ala Asp Asn Leu Ser 
                245                 250                 255     

Ser Asn Asp Ser Phe Ala Ser Gln Val Glu Gln Asn Pro Asp His Lys 
            260                 265                 270         

Gly Glu Ser Val Val Arg Pro Thr Val Pro Glu Gln Gly Asn Pro Val 
        275                 280                 285             

Ser Ala Thr Thr Val Gln Ser Ala Glu Glu Glu Val Leu Ala Thr Thr 
    290                 295                 300                 

Asn Asp Arg Pro Glu Tyr Lys Leu Pro Leu Glu Thr Lys Gly Thr Gln 
305                 310                 315                 320 

Glu Pro Gly His Glu Gly Glu Ala Ala Val Arg Glu Asp Leu Pro Val 
                325                 330                 335     

Tyr Thr Lys Pro Leu Glu Thr Lys Gly Thr Gln Gly Pro Gly His Glu 
            340                 345                 350         

Gly Glu Ala Ala Val Arg Glu Glu Glu Pro Ala Tyr Thr Glu Pro Leu 
        355                 360                 365             

Ala Thr Lys Gly Thr Gln Glu Pro Gly His Glu Gly Lys Ala Thr Val 
    370                 375                 380                 

Arg Glu Glu Thr Leu Glu Tyr Thr Glu Pro Val Ala Thr Lys Gly Thr 
385                 390                 395                 400 

Gln Glu Pro Glu His Glu Gly Glu Ala Ala Val Glu Glu Glu Leu Pro 
                405                 410                 415     

Ala Leu Glu Val Thr Thr Arg Asn Arg Thr Glu Ile Gln Asn Ile Pro 
            420                 425                 430         

Tyr Thr Thr Glu Glu Ile Gln Asp Pro Thr Leu Leu Lys Asn Arg Arg 
        435                 440                 445             

Lys Ile Glu Arg Gln Gly Gln Ala Gly Thr Arg Thr Ile Gln Tyr Glu 
    450                 455                 460                 

Asp Tyr Ile Val Asn Gly Asn Val Val Glu Thr Lys Glu Val Ser Arg 
465                 470                 475                 480 

Thr Glu Val Ala Pro Val Asn Glu Val Val Lys Val Gly Thr Leu Val 
                485                 490                 495     

Lys Val Lys Pro Thr Val Glu Ile Thr Asn Leu Thr Lys Val Glu Asn 
            500                 505                 510         

Lys Lys Ser Ile Thr Val Ser Tyr Asn Leu Ile Asp Thr Thr Ser Ala 
        515                 520                 525             

Tyr Val Ser Ala Lys Thr Gln Val Phe His Gly Asp Lys Leu Val Lys 
    530                 535                 540                 

Glu Val Asp Ile Glu Asn Pro Ala Lys Glu Gln Val Ile Ser Gly Leu 
545                 550                 555                 560 

Asp Tyr Tyr Thr Pro Tyr Thr Val Lys Thr His Leu Thr Tyr Asn Leu 
                565                 570                 575     

Gly Glu Asn Asn Glu Glu Asn Thr Glu Thr Ser Thr Gln Asp Phe Gln 
            580                 585                 590         

Leu Glu Tyr Lys Lys Ile Glu Ile Lys Asp Ile Asp Ser Val Glu Leu 
        595                 600                 605             

Tyr Gly Lys Glu Asn Asp Arg Tyr Arg Arg Tyr Leu Ser Leu Ser Glu 
    610                 615                 620                 

Ala Pro Thr Asp Thr Ala Lys Tyr Phe Val Lys Val Lys Ser Asp Arg 
625                 630                 635                 640 

Phe Lys Glu Met Tyr Leu Pro Val Lys Ser Ile Thr Glu Asn Thr Asp 
                645                 650                 655     

Gly Thr Tyr Lys Val Thr Val Ala Val Asp Gln Leu Val Glu Glu Gly 
            660                 665                 670         

Thr Asp Gly Tyr Lys Asp Asp Tyr Thr Phe Thr Val Ala Lys Ser Lys 
        675                 680                 685             

Ala Glu Gln Pro Gly Val Tyr Thr Ser Phe Lys Gln Leu Val Thr Ala 
    690                 695                 700                 

Met Gln Ser Asn Leu Ser Gly Val Tyr Thr Leu Ala Ser Asp Met Thr 
705                 710                 715                 720 

Ala Asp Glu Val Ser Leu Gly Asp Lys Gln Thr Ser Tyr Leu Thr Gly 
                725                 730                 735     

Ala Phe Thr Gly Ser Leu Ile Gly Ser Asp Gly Thr Lys Ser Tyr Ala 
            740                 745                 750         

Ile Tyr Asp Leu Lys Lys Pro Leu Phe Asp Thr Leu Asn Gly Ala Thr 
        755                 760                 765             

Val Arg Asp Leu Asp Ile Lys Thr Val Ser Ala Asp Ser Lys Glu Asn 
    770                 775                 780                 

Val Ala Ala Leu Ala Lys Ala Ala Asn Ser Ala Asn Ile Asn Asn Val 
785                 790                 795                 800 

Ala Val Glu Gly Lys Ile Ser Gly Ala Lys Ser Val Ala Gly Leu Val 
                805                 810                 815     

Ala Ser Ala Thr Asn Thr Val Ile Glu Asn Ser Ser Phe Thr Gly Lys 
            820                 825                 830         

Leu Ile Ala Asn His Gln Asp Ser Asn Lys Asn Asp Thr Gly Gly Ile 
        835                 840                 845             

Val Gly Asn Ile Thr Gly Asn Ser Ser Arg Val Asn Lys Val Arg Val 
    850                 855                 860                 

Asp Ala Leu Ile Ser Thr Asn Ala Arg Asn Asn Asn Gln Thr Ala Gly 
865                 870                 875                 880 

Gly Ile Val Gly Arg Leu Glu Asn Gly Ala Leu Ile Ser Asn Ser Val 
                885                 890                 895     

Ala Thr Gly Glu Ile Arg Asn Gly Gln Gly Tyr Ser Arg Val Gly Gly 
            900                 905                 910         

Ile Val Gly Ser Thr Trp Gln Asn Gly Arg Val Asn Asn Val Val Ser 
        915                 920                 925             

Asn Val Asp Val Gly Asp Gly Tyr Val Ile Thr Gly Asp Gln Tyr Ala 
    930                 935                 940                 

Ala Ala Asp Val Lys Asn Ala Ser Thr Ser Val Asp Asn Arg Lys Ala 
945                 950                 955                 960 

Asp Arg Phe Ala Thr Lys Leu Ser Lys Asp Gln Ile Asp Ala Lys Val 
                965                 970                 975     

Ala Asp Tyr Gly Ile Thr Val Thr Leu Asp Asp Thr Gly Gln Asp Leu 
            980                 985                 990         

Lys Arg Asn Leu Arg Glu Val Asp Tyr Thr Arg Leu Asn Lys Ala Glu 
        995                 1000                1005            

Ala Glu Arg Lys Val Ala Tyr Ser Asn Ile Glu Lys Leu Met Pro Phe 
    1010                1015                1020                

Tyr Asn Lys Asp Leu Val Val His Tyr Gly Asn Lys Val Ala Thr Thr 
1025                1030                1035                1040

Asp Lys Leu Tyr Thr Thr Glu Leu Leu Asp Val Val Pro Met Lys Asp 
                1045                1050                1055    

Asp Glu Val Val Thr Asp Ile Asn Asn Lys Lys Asn Ser Ile Asn Lys 
            1060                1065                1070        

Val Met Leu His Phe Lys Asp Asn Thr Val Glu Tyr Leu Asp Val Thr 
        1075                1080                1085            

Phe Lys Glu Asn Phe Ile Asn Ser Gln Val Ile Glu Tyr Asn Val Thr 
    1090                1095                1100                

Gly Lys Glu Tyr Ile Phe Thr Pro Glu Ala Phe Val Ser Asp Tyr Thr 
1105                1110                1115                1120

Ala Ile Thr Asn Asn Val Leu Ser Asp Leu Gln Asn Val Thr Leu Asn 
                1125                1130                1135    

Ser Glu Ala Thr Lys Lys Val Leu Gly Ala Ala Asn Asp Ala Ala Leu 
            1140                1145                1150        

Asp Asn Leu Tyr Leu Asp Arg Gln Phe Glu Glu Val Lys Ala Asn Ile 
        1155                1160                1165            

Ala Glu His Leu Arg Lys Val Leu Ala Met Asp Lys Ser Ile Asn Thr 
    1170                1175                1180                

Thr Gly Asp Gly Val Val Glu Tyr Val Ser Glu Lys Ile Lys Asn Asn 
1185                1190                1195                1200

Lys Glu Ala Phe Met Leu Gly Leu Thr Tyr Met Asn Arg Trp Tyr Asp 
                1205                1210                1215    

Ile Asn Tyr Gly Lys Met Asn Thr Lys Asp Leu Ser Thr Tyr Lys Phe 
            1220                1225                1230        

Asp Phe Asn Gly Asn Asn Glu Thr Ser Thr Leu Asp Thr Ile Val Ala 
        1235                1240                1245            

Leu Gly Asn Ser Gly Leu Asp Asn Leu Arg Ala Ser Asn Thr Val Gly 
    1250                1255                1260                

Leu Tyr Ala Asn Lys Leu Ala Ser Val Lys Gly Glu Asp Ser Val Phe 
1265                1270                1275                1280

Asp Phe Val Glu Ala Tyr Arg Lys Leu Phe Leu Pro Asn Lys Thr Asn 
                1285                1290                1295    

Asn Glu Trp Phe Lys Glu Asn Thr Lys Ala Tyr Ile Val Glu Met Lys 
            1300                1305                1310        

Ser Asp Ile Ala Glu Val Arg Glu Lys Gln Glu Ser Pro Thr Ala Asp 
        1315                1320                1325            

Arg Lys Tyr Ser Leu Gly Val Tyr Asp Arg Ile Ser Ala Pro Ser Trp 
    1330                1335                1340                

Gly His Lys Ser Met Leu Leu Pro Leu Leu Thr Leu Pro Glu Glu Ser 
1345                1350                1355                1360

Val Tyr Ile Ser Ser Asn Met Ser Thr Leu Ala Phe Gly Ser Tyr Glu 
                1365                1370                1375    

Arg Tyr Arg Asp Ser Val Asp Gly Val Ile Leu Ser Gly Asp Ala Leu 
            1380                1385                1390        

Arg Thr Tyr Val Arg Asn Arg Val Asp Ile Ala Ala Lys Arg His Arg 
        1395                1400                1405            

Asp His Tyr Asp Ile Trp Tyr Asn Leu Leu Asp Ser Ala Ser Lys Glu 
    1410                1415                1420                

Lys Leu Phe Arg Ser Val Ile Val Tyr Asp Gly Phe Asn Val Lys Asp 
1425                1430                1435                1440

Glu Thr Gly Arg Thr Tyr Trp Ala Arg Leu Thr Asp Lys Asn Ile Gly 
                1445                1450                1455    

Ser Ile Lys Glu Phe Phe Gly Pro Val Gly Lys Trp Tyr Glu Tyr Asn 
            1460                1465                1470        

Ser Ser Ala Gly Ala Tyr Ala Asn Gly Ser Leu Thr His Phe Val Leu 
        1475                1480                1485            

Asp Arg Leu Leu Asp Ala Tyr Gly Thr Ser Val Tyr Thr His Glu Met 
    1490                1495                1500                

Val His Asn Ser Asp Ser Ala Ile Tyr Phe Glu Gly Asn Gly Arg Arg 
1505                1510                1515                1520

Glu Gly Leu Gly Ala Glu Leu Tyr Ala Leu Gly Leu Leu Gln Ser Val 
                1525                1530                1535    

Asp Ser Val Asn Ser His Ile Leu Ala Leu Asn Thr Leu Tyr Lys Ala 
            1540                1545                1550        

Glu Lys Asp Asp Leu Asn Arg Leu His Thr Tyr Asn Pro Val Glu Arg 
        1555                1560                1565            

Phe Asp Ser Asp Glu Ala Leu Gln Ser Tyr Met His Gly Ser Tyr Asp 
    1570                1575                1580                

Val Met Tyr Thr Leu Asp Ala Met Glu Ala Lys Ala Ile Leu Ala Gln 
1585                1590                1595                1600

Asn Asn Asp Val Lys Lys Lys Trp Phe Arg Lys Ile Glu Asn Tyr Tyr 
                1605                1610                1615    

Val Arg Asp Thr Arg His Asn Lys Asp Thr His Ala Gly Asn Lys Val 
            1620                1625                1630        

Arg Pro Leu Thr Asp Glu Glu Val Ala Asn Leu Thr Ser Leu Asn Ser 
        1635                1640                1645            

Leu Ile Asp Asn Asp Ile Ile Asn Arg Arg Ser Tyr Asp Asp Ser Arg 
    1650                1655                1660                

Glu Tyr Lys Arg Asn Gly Tyr Tyr Thr Ile Ser Met Phe Ser Pro Val 
1665                1670                1675                1680

Tyr Ala Ala Leu Ser Asn Ser Lys Gly Ala Pro Gly Asp Ile Met Phe 
                1685                1690                1695    

Arg Lys Ile Ala Tyr Glu Leu Leu Ala Glu Lys Gly Tyr His Lys Gly 
            1700                1705                1710        

Phe Leu Pro Tyr Val Ser Asn Gln Tyr Gly Ala Glu Ala Phe Ala Ser 
        1715                1720                1725            

Gly Ser Lys Thr Phe Ser Ser Trp His Gly Arg Asp Val Ala Leu Val 
    1730                1735                1740                

Thr Asp Asp Leu Val Phe Lys Lys Val Phe Asn Gly Glu Tyr Ser Ser 
1745                1750                1755                1760

Trp Ala Asp Phe Lys Lys Ala Met Phe Lys Gln Arg Ile Asp Lys Gln 
                1765                1770                1775    

Asp Asn Leu Lys Pro Ile Thr Ile Gln Tyr Glu Leu Gly Asn Pro Asn 
            1780                1785                1790        

Ser Thr Lys Glu Val Thr Ile Thr Thr Ala Ala Gln Met Gln Gln Leu 
        1795                1800                1805            

Ile Asn Glu Ala Ala Ala Lys Asp Ile Thr Asn Ile Asp Arg Ala Thr 
    1810                1815                1820                

Ser His Thr Pro Ala Ser Trp Val His Leu Leu Lys Gln Lys Ile Tyr 
1825                1830                1835                1840

Asn Ala Tyr Leu Arg Thr Thr Asp Asp Phe Arg Asn Ser Ile Tyr Lys 
                1845                1850                1855    


<210>   4857
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4857
atgcagattg caggaatcat cttcaactca tcaacgacca atggtgacaa ggtggatttc   60
aatcccacag aaaatgttga tttgagaaat aactttgcta gtctagtaaa a            111

<210>   4858
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4858
Met Gln Ile Ala Gly Ile Ile Phe Asn Ser Ser Thr Thr Asn Gly Asp 
1               5                   10                  15      

Lys Val Asp Phe Asn Pro Thr Glu Asn Val Asp Leu Arg Asn Asn Phe 
            20                  25                  30          

Ala Ser Leu Val Lys 
        35          

<210>   4859
<211>   852
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4859
atgacatatg aataccagag ccacatttat ttagcagagg cagttttaaa tgtgaaggat   60
ttggtcagtc aaacagtttt ttatcagcag attattggtt tagaaatcct atctcaaacg   120
gatacagagg tcgttctggg acttggagga aaagccttgg tacacttgat tcaagcacaa   180
gagggtggag aagtaaggga acattatggt ctttaccatc tggctattct tttgccgaca   240
cgaaaggctt tggcggatgt cttgaagcac ctgacggatt tacagattcc tcttgttggc   300
ggtgcagatc acggttacag tgaggccctt tacttagagg acttggaggg aaatggcatt   360
gaactctatc gagataagcc agtttccaca tgggatattc gagaagatgg acgtattatc   420
ggggtgactg aagtccttgc ggctcaggat atctatgagt tgggggaaag agtagagcct   480
tttatcctag cagagggtac gagaatgggg catattcatc tttctgtcaa ggatagtcga   540
aagtccagac agttttatca aacggtgtta gggctcgagg ataaattcag tgtgcctagt   600
gctagttgga tcgcagctgg ggactaccat catcatttag cagtcaacga atggggagga   660
aaaggtctgg atccgcgtaa acaagtccta ccaggtttag cctactatgt catcgaagtc   720
gcacataaag aagaactgtt aacgattgcc caacgagcac aagaagttga cgcaccaatc   780
aaatggatga catcgatcca attggaaatc acagactcag atggcatcgt gacccgtatt   840
cgtttagcta ga                                                       852

<210>   4860
<211>   284
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902110 (e-149)

<400>   4860
Met Thr Tyr Glu Tyr Gln Ser His Ile Tyr Leu Ala Glu Ala Val Leu 
1               5                   10                  15      

Asn Val Lys Asp Leu Val Ser Gln Thr Val Phe Tyr Gln Gln Ile Ile 
            20                  25                  30          

Gly Leu Glu Ile Leu Ser Gln Thr Asp Thr Glu Val Val Leu Gly Leu 
        35                  40                  45              

Gly Gly Lys Ala Leu Val His Leu Ile Gln Ala Gln Glu Gly Gly Glu 
    50                  55                  60                  

Val Arg Glu His Tyr Gly Leu Tyr His Leu Ala Ile Leu Leu Pro Thr 
65                  70                  75                  80  

Arg Lys Ala Leu Ala Asp Val Leu Lys His Leu Thr Asp Leu Gln Ile 
                85                  90                  95      

Pro Leu Val Gly Gly Ala Asp His Gly Tyr Ser Glu Ala Leu Tyr Leu 
            100                 105                 110         

Glu Asp Leu Glu Gly Asn Gly Ile Glu Leu Tyr Arg Asp Lys Pro Val 
        115                 120                 125             

Ser Thr Trp Asp Ile Arg Glu Asp Gly Arg Ile Ile Gly Val Thr Glu 
    130                 135                 140                 

Val Leu Ala Ala Gln Asp Ile Tyr Glu Leu Gly Glu Arg Val Glu Pro 
145                 150                 155                 160 

Phe Ile Leu Ala Glu Gly Thr Arg Met Gly His Ile His Leu Ser Val 
                165                 170                 175     

Lys Asp Ser Arg Lys Ser Arg Gln Phe Tyr Gln Thr Val Leu Gly Leu 
            180                 185                 190         

Glu Asp Lys Phe Ser Val Pro Ser Ala Ser Trp Ile Ala Ala Gly Asp 
        195                 200                 205             

Tyr His His His Leu Ala Val Asn Glu Trp Gly Gly Lys Gly Leu Asp 
    210                 215                 220                 

Pro Arg Lys Gln Val Leu Pro Gly Leu Ala Tyr Tyr Val Ile Glu Val 
225                 230                 235                 240 

Ala His Lys Glu Glu Leu Leu Thr Ile Ala Gln Arg Ala Gln Glu Val 
                245                 250                 255     

Asp Ala Pro Ile Lys Trp Met Thr Ser Ile Gln Leu Glu Ile Thr Asp 
            260                 265                 270         

Ser Asp Gly Ile Val Thr Arg Ile Arg Leu Ala Arg 
        275                 280                 

<210>   4861
<211>   660
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4861
atggtatgtg atgaaggtag agcatcaatt gtagaaagtg ctccttattc tagtcagata   60
cgtggaaaat ttgatatgat agtagggaat aaggagaaga ataatatgac tagcgaatac   120
cagaaaatga tagcaggaga gttttaccgt ccatcagacc cagaactgag agccttagct   180
caggcttctc gccaaaaaca ggccgccttt aacaaggaag agaacccctt gaagggagcc   240
gaaatcatca agacttggtt tgcctcaacc gggaaaaatc tttacatcaa cactcgcttg   300
atggtggact acggtgtcaa catccatcta ggggaaaatt tttattctaa ttggaacttg   360
accatgctgg atatctgtcc cattcgtatc ggggacaatg ctatgattgg tcctaattgt   420
cagtttttga cacccctcca tccactagat ccacaggaac gcaattcagg tatcgagtac   480
ggaaagccta tcacaatcgg agataatttc tggactggtg gtggcgtcat tgtccttcct   540
ggagtgacac tgggaaataa tgtcgttgca ggagcagggg cagtaattac caaatctttt   600
ggcgacaacg ttgtcctagc tggcaatcct gcgcgcgtga ttaaggaaat acctgttaaa   660

<210>   4862
<211>   220
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   acetyltransferase, CysE/LacA/LpxA/NodL family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903948 (1.E-11)

<400>   4862
Met Val Cys Asp Glu Gly Arg Ala Ser Ile Val Glu Ser Ala Pro Tyr 
1               5                   10                  15      

Ser Ser Gln Ile Arg Gly Lys Phe Asp Met Ile Val Gly Asn Lys Glu 
            20                  25                  30          

Lys Asn Asn Met Thr Ser Glu Tyr Gln Lys Met Ile Ala Gly Glu Phe 
        35                  40                  45              

Tyr Arg Pro Ser Asp Pro Glu Leu Arg Ala Leu Ala Gln Ala Ser Arg 
    50                  55                  60                  

Gln Lys Gln Ala Ala Phe Asn Lys Glu Glu Asn Pro Leu Lys Gly Ala 
65                  70                  75                  80  

Glu Ile Ile Lys Thr Trp Phe Ala Ser Thr Gly Lys Asn Leu Tyr Ile 
                85                  90                  95      

Asn Thr Arg Leu Met Val Asp Tyr Gly Val Asn Ile His Leu Gly Glu 
            100                 105                 110         

Asn Phe Tyr Ser Asn Trp Asn Leu Thr Met Leu Asp Ile Cys Pro Ile 
        115                 120                 125             

Arg Ile Gly Asp Asn Ala Met Ile Gly Pro Asn Cys Gln Phe Leu Thr 
    130                 135                 140                 

Pro Leu His Pro Leu Asp Pro Gln Glu Arg Asn Ser Gly Ile Glu Tyr 
145                 150                 155                 160 

Gly Lys Pro Ile Thr Ile Gly Asp Asn Phe Trp Thr Gly Gly Gly Val 
                165                 170                 175     

Ile Val Leu Pro Gly Val Thr Leu Gly Asn Asn Val Val Ala Gly Ala 
            180                 185                 190         

Gly Ala Val Ile Thr Lys Ser Phe Gly Asp Asn Val Val Leu Ala Gly 
        195                 200                 205             

Asn Pro Ala Arg Val Ile Lys Glu Ile Pro Val Lys 
    210                 215                 220 

<210>   4863
<211>   762
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4863
atgattcaga aacatgcgat tcctatttta gagtttgatg acaatcctca ggcggttatc   60
atgcccaatc acgaggggct ggacttgcag ttgccaaaga agtgtgttta tgcattttta   120
ggtgaggaga ttgaccgcta tgcgagggaa gtaggggcga actgtgttgg cgaatttgtt   180
tctgccacca agacctatcc agtttatgtc gtgaactaca aggacgagga ggtctgtctg   240
gctcaggctc ctgttggctc cgctccagca gcccagttta tggattggtt gattggctat   300
ggtgtggagc agattatctc tactgggacc tgtggtgtcc tagctgatat agaggaaaat   360
gcctttctag tccctgttcg cgctctgcga gatgaaggag ccagttacca ctatgtggca   420
ccttgtcgtt atatggaaat gcagccagag gctattgctg ctattgagga agttttggaa   480
gacagaggga ttccttatga agaagtcatg acctggacga cagacggttt ttaccgagaa   540
acggctgaaa aggtggctta tcgtaaggaa gaaggctgtg ctgttgtgga gatggagtgt   600
tctgctcttg cggcagtagc tcaattgcgt ggggttctct ggggtgaatt gttgttcaca   660
gcagattctc tagcggactt ggaccagtac gacagtcgtg actggggctc ggaagctttt   720
aataaggcgc tagaactgag tttagcaagt gttcaccacc tt                      762

<210>   4864
<211>   254
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   phosphorylase, Pnp/Udp family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902112 (e-135)

<400>   4864
Met Ile Gln Lys His Ala Ile Pro Ile Leu Glu Phe Asp Asp Asn Pro 
1               5                   10                  15      

Gln Ala Val Ile Met Pro Asn His Glu Gly Leu Asp Leu Gln Leu Pro 
            20                  25                  30          

Lys Lys Cys Val Tyr Ala Phe Leu Gly Glu Glu Ile Asp Arg Tyr Ala 
        35                  40                  45              

Arg Glu Val Gly Ala Asn Cys Val Gly Glu Phe Val Ser Ala Thr Lys 
    50                  55                  60                  

Thr Tyr Pro Val Tyr Val Val Asn Tyr Lys Asp Glu Glu Val Cys Leu 
65                  70                  75                  80  

Ala Gln Ala Pro Val Gly Ser Ala Pro Ala Ala Gln Phe Met Asp Trp 
                85                  90                  95      

Leu Ile Gly Tyr Gly Val Glu Gln Ile Ile Ser Thr Gly Thr Cys Gly 
            100                 105                 110         

Val Leu Ala Asp Ile Glu Glu Asn Ala Phe Leu Val Pro Val Arg Ala 
        115                 120                 125             

Leu Arg Asp Glu Gly Ala Ser Tyr His Tyr Val Ala Pro Cys Arg Tyr 
    130                 135                 140                 

Met Glu Met Gln Pro Glu Ala Ile Ala Ala Ile Glu Glu Val Leu Glu 
145                 150                 155                 160 

Asp Arg Gly Ile Pro Tyr Glu Glu Val Met Thr Trp Thr Thr Asp Gly 
                165                 170                 175     

Phe Tyr Arg Glu Thr Ala Glu Lys Val Ala Tyr Arg Lys Glu Glu Gly 
            180                 185                 190         

Cys Ala Val Val Glu Met Glu Cys Ser Ala Leu Ala Ala Val Ala Gln 
        195                 200                 205             

Leu Arg Gly Val Leu Trp Gly Glu Leu Leu Phe Thr Ala Asp Ser Leu 
    210                 215                 220                 

Ala Asp Leu Asp Gln Tyr Asp Ser Arg Asp Trp Gly Ser Glu Ala Phe 
225                 230                 235                 240 

Asn Lys Ala Leu Glu Leu Ser Leu Ala Ser Val His His Leu 
                245                 250                 

<210>   4865
<211>   90
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4865
ttgatagatg tgactatagg tcaaaaaagc aagacaggag cttttaacgc cagctactct   60
atatgctttt caggagaaaa tttctctttt                                    90

<210>   4866
<211>   30
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4866
Met Ile Asp Val Thr Ile Gly Gln Lys Ser Lys Thr Gly Ala Phe Asn 
1               5                   10                  15      

Ala Ser Tyr Ser Ile Cys Phe Ser Gly Glu Asn Phe Ser Phe 
            20                  25                  30  

<210>   4867
<211>   156
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4867
ttgacctata gtcacatcta tcaagtattg ttcttgccta agctatcaat aaaaaggtgg   60
cattttttag gcttggtgtt agtagatttt gccttatcct atctaagtca tttcgaactt   120
tttatggtac aatggaaaca tgttattcaa attatc                             156

<210>   4868
<211>   52
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902113 (3.E-26)

<400>   4868
Met Thr Tyr Ser His Ile Tyr Gln Val Leu Phe Leu Pro Lys Leu Ser 
1               5                   10                  15      

Ile Lys Arg Trp His Phe Leu Gly Leu Val Leu Val Asp Phe Ala Leu 
            20                  25                  30          

Ser Tyr Leu Ser His Phe Glu Leu Phe Met Val Gln Trp Lys His Val 
        35                  40                  45              

Ile Gln Ile Ile 
    50          

<210>   4869
<211>   1377
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4869
atgttattca aattatctaa ggaaaaaata gagctaggct tatctcgttt atcgccagcc   60
cgtcgtattt ttttgagttt tgccttggtc attttactag gctctcttct tttgagcttg   120
ccctttgtcc aagttgaaag ctcacgagcg acttattttg atcatctttt cactgctgtc   180
tctgcagtct gtgtgacggg tctctcaacc cttccagtag ctcacaccta taatatctgg   240
ggtcaaataa tctgtttgct cttgattcag atcggtggtc tagggctcat gacctttatt   300
ggggttttct atatccagag caagcaaaag cttagtcttc gtagccgtgc aactattcag   360
gatagtttta gttatggaga aactcgatct ttgagaaagt ttgtctattc tatttttctc   420
acgacctttt tggttgagag cttgggagct attttgctta gttttcgcct tattcctcaa   480
cttggctggg gacgtggtct ttttagttcc atttttctag cgatctcagc cttctgtaat   540
gccggttttg ataatttagg gagcaccagt ttatttgctt ttcagaccga tttactggtc   600
aatctggtga ttgcaggctt gattattaca ggcggccttg gttttatggt ctggtttgat   660
ttggctggtc atgtaggaag aaagaaaaaa ggacgtctgc actttcatac gaagcttgta   720
ctattattga ctataggttt gttgttattt ggaacagcaa ctactctctt tcttgagtgg   780
aacaatgctg gaacgattgg caatctccct gttgccgata aggttttagt tagctttttt   840
caaacagtga cgatgcgaac agctggcttt tctacgatag attatactca ggctcatcct   900
gtgactcttt tgatttatat cttacagatg tttctaggtg gggcacctgg aggaacagct   960
gggggactca agattacgac attttttgtc ctcttggtct ttgcacgaag tgagcttcta   1020
ggcttgcctc atgccaatgt tgcgagacga acgatcgcgc cgcgaacggt tcaaaaatcc   1080
tttagtgtct ttattatctt tttgatgagc ttcttgatag gattgattct gctagggata   1140
acagccaaag gcaatcctcc ctttatccac ctcgtatttg aaaccatttc agctcttagt   1200
acagttggtg taacggcaaa tctgactcct gaccttggga aattggctct cagtgttatc   1260
atgccactta tgtttatggg acgaattggt cccttgacct tgtttgttag cttggcagat   1320
taccatccag aaaagaaaga tatgattcac tatatgaaag cagatattag tattggt      1377

<210>   4870
<211>   459
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   potassium uptake protein, Trk family
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902114 (0.E+01)

<400>   4870
Met Leu Phe Lys Leu Ser Lys Glu Lys Ile Glu Leu Gly Leu Ser Arg 
1               5                   10                  15      

Leu Ser Pro Ala Arg Arg Ile Phe Leu Ser Phe Ala Leu Val Ile Leu 
            20                  25                  30          

Leu Gly Ser Leu Leu Leu Ser Leu Pro Phe Val Gln Val Glu Ser Ser 
        35                  40                  45              

Arg Ala Thr Tyr Phe Asp His Leu Phe Thr Ala Val Ser Ala Val Cys 
    50                  55                  60                  

Val Thr Gly Leu Ser Thr Leu Pro Val Ala His Thr Tyr Asn Ile Trp 
65                  70                  75                  80  

Gly Gln Ile Ile Cys Leu Leu Leu Ile Gln Ile Gly Gly Leu Gly Leu 
                85                  90                  95      

Met Thr Phe Ile Gly Val Phe Tyr Ile Gln Ser Lys Gln Lys Leu Ser 
            100                 105                 110         

Leu Arg Ser Arg Ala Thr Ile Gln Asp Ser Phe Ser Tyr Gly Glu Thr 
        115                 120                 125             

Arg Ser Leu Arg Lys Phe Val Tyr Ser Ile Phe Leu Thr Thr Phe Leu 
    130                 135                 140                 

Val Glu Ser Leu Gly Ala Ile Leu Leu Ser Phe Arg Leu Ile Pro Gln 
145                 150                 155                 160 

Leu Gly Trp Gly Arg Gly Leu Phe Ser Ser Ile Phe Leu Ala Ile Ser 
                165                 170                 175     

Ala Phe Cys Asn Ala Gly Phe Asp Asn Leu Gly Ser Thr Ser Leu Phe 
            180                 185                 190         

Ala Phe Gln Thr Asp Leu Leu Val Asn Leu Val Ile Ala Gly Leu Ile 
        195                 200                 205             

Ile Thr Gly Gly Leu Gly Phe Met Val Trp Phe Asp Leu Ala Gly His 
    210                 215                 220                 

Val Gly Arg Lys Lys Lys Gly Arg Leu His Phe His Thr Lys Leu Val 
225                 230                 235                 240 

Leu Leu Leu Thr Ile Gly Leu Leu Leu Phe Gly Thr Ala Thr Thr Leu 
                245                 250                 255     

Phe Leu Glu Trp Asn Asn Ala Gly Thr Ile Gly Asn Leu Pro Val Ala 
            260                 265                 270         

Asp Lys Val Leu Val Ser Phe Phe Gln Thr Val Thr Met Arg Thr Ala 
        275                 280                 285             

Gly Phe Ser Thr Ile Asp Tyr Thr Gln Ala His Pro Val Thr Leu Leu 
    290                 295                 300                 

Ile Tyr Ile Leu Gln Met Phe Leu Gly Gly Ala Pro Gly Gly Thr Ala 
305                 310                 315                 320 

Gly Gly Leu Lys Ile Thr Thr Phe Phe Val Leu Leu Val Phe Ala Arg 
                325                 330                 335     

Ser Glu Leu Leu Gly Leu Pro His Ala Asn Val Ala Arg Arg Thr Ile 
            340                 345                 350         

Ala Pro Arg Thr Val Gln Lys Ser Phe Ser Val Phe Ile Ile Phe Leu 
        355                 360                 365             

Met Ser Phe Leu Ile Gly Leu Ile Leu Leu Gly Ile Thr Ala Lys Gly 
    370                 375                 380                 

Asn Pro Pro Phe Ile His Leu Val Phe Glu Thr Ile Ser Ala Leu Ser 
385                 390                 395                 400 

Thr Val Gly Val Thr Ala Asn Leu Thr Pro Asp Leu Gly Lys Leu Ala 
                405                 410                 415     

Leu Ser Val Ile Met Pro Leu Met Phe Met Gly Arg Ile Gly Pro Leu 
            420                 425                 430         

Thr Leu Phe Val Ser Leu Ala Asp Tyr His Pro Glu Lys Lys Asp Met 
        435                 440                 445             

Ile His Tyr Met Lys Ala Asp Ile Ser Ile Gly 
    450                 455                 

<210>   4871
<211>   663
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4871
atgtcagatc gtacgattgg aattttgggc ttgggaattt ttgggagcag tgtcctagct   60
gccctagcca agcaggatat gaatattatc gctattgatg accacgcaga gcgcatcaat   120
cagtttgagc cagttttggc gcgtggagtg attggtgaca tcacagatga agaattattg   180
agatcagcag ggattgatac ctgcgatacc gttgtagtcg cgacaggtga aaatctggag   240
tcgagtgtgc ttgcggttat gcactgtaag agtttggggg taccgactgt tattgctaag   300
gtcaaaagtc agaccgctaa gaaagtgcta gaaaagattg gagctgactc ggttatctcg   360
ccagagtatg aaatggggca gtctctagca cagaccattc ttttccataa tagtgttgat   420
gtctttcagt tggataaaaa tgtgtctatc gtggagatga aaattcctca gtcttgggca   480
ggtcaaagtc tgagtaaatt agacctccgt ggcaaataca atctgaatat tttgggtttc   540
cgagagcagg aaaattcccc attggatgtt gaatttggac cagatgacct cttgaaagca   600
gatacctata ttttggcagt catcaacaac cagtatttgg ataccctagt agcattgaat   660
tcg                                                                 663

<210>   4872
<211>   221
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   potassium uptake protein, Trk family
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902115 (e-121)

<400>   4872
Met Ser Asp Arg Thr Ile Gly Ile Leu Gly Leu Gly Ile Phe Gly Ser 
1               5                   10                  15      

Ser Val Leu Ala Ala Leu Ala Lys Gln Asp Met Asn Ile Ile Ala Ile 
            20                  25                  30          

Asp Asp His Ala Glu Arg Ile Asn Gln Phe Glu Pro Val Leu Ala Arg 
        35                  40                  45              

Gly Val Ile Gly Asp Ile Thr Asp Glu Glu Leu Leu Arg Ser Ala Gly 
    50                  55                  60                  

Ile Asp Thr Cys Asp Thr Val Val Val Ala Thr Gly Glu Asn Leu Glu 
65                  70                  75                  80  

Ser Ser Val Leu Ala Val Met His Cys Lys Ser Leu Gly Val Pro Thr 
                85                  90                  95      

Val Ile Ala Lys Val Lys Ser Gln Thr Ala Lys Lys Val Leu Glu Lys 
            100                 105                 110         

Ile Gly Ala Asp Ser Val Ile Ser Pro Glu Tyr Glu Met Gly Gln Ser 
        115                 120                 125             

Leu Ala Gln Thr Ile Leu Phe His Asn Ser Val Asp Val Phe Gln Leu 
    130                 135                 140                 

Asp Lys Asn Val Ser Ile Val Glu Met Lys Ile Pro Gln Ser Trp Ala 
145                 150                 155                 160 

Gly Gln Ser Leu Ser Lys Leu Asp Leu Arg Gly Lys Tyr Asn Leu Asn 
                165                 170                 175     

Ile Leu Gly Phe Arg Glu Gln Glu Asn Ser Pro Leu Asp Val Glu Phe 
            180                 185                 190         

Gly Pro Asp Asp Leu Leu Lys Ala Asp Thr Tyr Ile Leu Ala Val Ile 
        195                 200                 205             

Asn Asn Gln Tyr Leu Asp Thr Leu Val Ala Leu Asn Ser 
    210                 215                 220     

<210>   4873
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4873
ttgatgccta agatggcaaa tagagacaga agccccttgt cttctagtaa aagttcttca   60
aaggctggac tttatggtaa aatagaaaga agtgacaaga gagag                   105

<210>   4874
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4874
Met Met Pro Lys Met Ala Asn Arg Asp Arg Ser Pro Leu Ser Ser Ser 
1               5                   10                  15      

Lys Ser Ser Ser Lys Ala Gly Leu Tyr Gly Lys Ile Glu Arg Ser Asp 
            20                  25                  30          

Lys Arg Glu 
        35  

<210>   4875
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4875
atgaaaatca aagatcaaac taggaaacta gctacgggct gctcaaaaca ctgttttgag   60
gttgcagata gaactgacga agtcagtaac atctatacgg caaggcgacg t            111

<210>   4876
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4876
Met Lys Ile Lys Asp Gln Thr Arg Lys Leu Ala Thr Gly Cys Ser Lys 
1               5                   10                  15      

His Cys Phe Glu Val Ala Asp Arg Thr Asp Glu Val Ser Asn Ile Tyr 
            20                  25                  30          

Thr Ala Arg Arg Arg 
        35          

<210>   4877
<211>   537
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4877
atgaagttat tgtctatcgc aatttctagc tataatgcag cagcctatct tcattactgt   60
gtggagtcgc tagtgattgg tggtgagcaa gttgggattt tgattatcaa tgacgggtct   120
caggatcaga ctcaggaaat cgctgagtgt ttagctagca agtatcctaa tatcgttaga   180
gccatctatc aggaaaataa atgccatggc ggtgcggtca atcgtggctt ggtagaggct   240
tctgggcgct attttaaagt agttgacagt gatgactggg tggatcctcg tgcctacttg   300
aaaattcttg aaaccttgca ggaacttgag agcaaaggtc aagaggtgga tgtctttgtg   360
accaattttg tctatgaaaa ggaagggcag tctcgtaaga agagtatgag ttacgattca   420
gtcttgcctg ttcggcagat ttttggctgg gaccaggtcg gaaatttctc caaaggccag   480
tataccatga tgcactcgct gatttatcgg acagatttgt tgcgtgctag ccagttc      537

<210>   4878
<211>   179
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase, family 2 POINT MUTATION

<400>   4878
Met Lys Leu Leu Ser Ile Ala Ile Ser Ser Tyr Asn Ala Ala Ala Tyr 
1               5                   10                  15      

Leu His Tyr Cys Val Glu Ser Leu Val Ile Gly Gly Glu Gln Val Gly 
            20                  25                  30          

Ile Leu Ile Ile Asn Asp Gly Ser Gln Asp Gln Thr Gln Glu Ile Ala 
        35                  40                  45              

Glu Cys Leu Ala Ser Lys Tyr Pro Asn Ile Val Arg Ala Ile Tyr Gln 
    50                  55                  60                  

Glu Asn Lys Cys His Gly Gly Ala Val Asn Arg Gly Leu Val Glu Ala 
65                  70                  75                  80  

Ser Gly Arg Tyr Phe Lys Val Val Asp Ser Asp Asp Trp Val Asp Pro 
                85                  90                  95      

Arg Ala Tyr Leu Lys Ile Leu Glu Thr Leu Gln Glu Leu Glu Ser Lys 
            100                 105                 110         

Gly Gln Glu Val Asp Val Phe Val Thr Asn Phe Val Tyr Glu Lys Glu 
        115                 120                 125             

Gly Gln Ser Arg Lys Lys Ser Met Ser Tyr Asp Ser Val Leu Pro Val 
    130                 135                 140                 

Arg Gln Ile Phe Gly Trp Asp Gln Val Gly Asn Phe Ser Lys Gly Gln 
145                 150                 155                 160 

Tyr Thr Met Met His Ser Leu Ile Tyr Arg Thr Asp Leu Leu Arg Ala 
                165                 170                 175     

Ser Gln Phe 

            

<210>   4879
<211>   408
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4879
atgtactatc tgcctgtcga tttctatcgt tatttgattg ggcgtgagga ccagtctgtc   60
aatgagcaag tgatgattaa gtgcattgac cagcaactca aggtcaatcg actcttgata   120
gaccaacttg atttgtccca agtgagtcat cccaaaatgc gagaatatct gctgaatcat   180
attgaactca cgacggtgat ttccagtacc ctgctcaacc gatctggaac agcggagcat   240
ctggcaaaaa aacgccaatt gtggacctat attcagcaga aaaatccaga agtctttcag   300
gctattcgta agaccatgtt gagccgtttg accaaacatt ctgtcttgcc agatcgcaaa   360
ctgtccaatg tcgtctatca aatcaccaaa tctgtttatg gatttaat                408

<210>   4880
<211>   136
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4880
Met Tyr Tyr Leu Pro Val Asp Phe Tyr Arg Tyr Leu Ile Gly Arg Glu 
1               5                   10                  15      

Asp Gln Ser Val Asn Glu Gln Val Met Ile Lys Cys Ile Asp Gln Gln 
            20                  25                  30          

Leu Lys Val Asn Arg Leu Leu Ile Asp Gln Leu Asp Leu Ser Gln Val 
        35                  40                  45              

Ser His Pro Lys Met Arg Glu Tyr Leu Leu Asn His Ile Glu Leu Thr 
    50                  55                  60                  

Thr Val Ile Ser Ser Thr Leu Leu Asn Arg Ser Gly Thr Ala Glu His 
65                  70                  75                  80  

Leu Ala Lys Lys Arg Gln Leu Trp Thr Tyr Ile Gln Gln Lys Asn Pro 
                85                  90                  95      

Glu Val Phe Gln Ala Ile Arg Lys Thr Met Leu Ser Arg Leu Thr Lys 
            100                 105                 110         

His Ser Val Leu Pro Asp Arg Lys Leu Ser Asn Val Val Tyr Gln Ile 
        115                 120                 125             

Thr Lys Ser Val Tyr Gly Phe Asn 
    130                 135     

<210>   4881
<211>   567
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4881
ttgatagacg acattggaca gtttgcgatc tggcaagaca gaatgtttgg tcaaacggct   60
caacatggtc ttacgaatag cctgaaagac ttctggattt ttctgctgaa tataggtcca   120
caattggcgt ttttttgcca gatgctccgc tgttccagat cggttgagca gggtactgga   180
aatcaccgtc gtgagttcaa tatgattcag cagatattct cgcattttgg gatgactcac   240
ttgggacaaa tcaagttggt ctatcaagag tcgattgacc ttgagttgct ggtcaatgca   300
cttaatcatc acttgctcat tgacagactg gtcctcacgc ccaatcaaat aacgatagaa   360
atcgacaggc agatagtaca tggtcttgac ctgctgaagg ggcgtaaaga caaagagatt   420
atcgacataa aaagtatgtt caggcagtta gaactggcta gcacgcaaca aatctgtccg   480
ataaatcagc gagtgcatca tggtatactg gcctttggag aaatttccga cctggtccca   540
gccaaaaatc tgccgaacag gcaagac                                       567

<210>   4882
<211>   189
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4882
Met Ile Asp Asp Ile Gly Gln Phe Ala Ile Trp Gln Asp Arg Met Phe 
1               5                   10                  15      

Gly Gln Thr Ala Gln His Gly Leu Thr Asn Ser Leu Lys Asp Phe Trp 
            20                  25                  30          

Ile Phe Leu Leu Asn Ile Gly Pro Gln Leu Ala Phe Phe Cys Gln Met 
        35                  40                  45              

Leu Arg Cys Ser Arg Ser Val Glu Gln Gly Thr Gly Asn His Arg Arg 
    50                  55                  60                  

Glu Phe Asn Met Ile Gln Gln Ile Phe Ser His Phe Gly Met Thr His 
65                  70                  75                  80  

Leu Gly Gln Ile Lys Leu Val Tyr Gln Glu Ser Ile Asp Leu Glu Leu 
                85                  90                  95      

Leu Val Asn Ala Leu Asn His His Leu Leu Ile Asp Arg Leu Val Leu 
            100                 105                 110         

Thr Pro Asn Gln Ile Thr Ile Glu Ile Asp Arg Gln Ile Val His Gly 
        115                 120                 125             

Leu Asp Leu Leu Lys Gly Arg Lys Asp Lys Glu Ile Ile Asp Ile Lys 
    130                 135                 140                 

Ser Met Phe Arg Gln Leu Glu Leu Ala Ser Thr Gln Gln Ile Cys Pro 
145                 150                 155                 160 

Ile Asn Gln Arg Val His His Gly Ile Leu Ala Phe Gly Glu Ile Ser 
                165                 170                 175     

Asp Leu Val Pro Ala Lys Asn Leu Pro Asn Arg Gln Asp 
            180                 185                 

<210>   4883
<211>   2571
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4883
atgaaattca atccaaatca aagatatact cgttggtcta ttcgccgtct cagtgtcggt   60
gttgcctcag ttgttgtggc tagtggcttc tttgtcctag ttggtcagcc aagttctgta   120
cgtgccgatg ggctcaatcc aaccccaggt caagtcttac ctgaagagac atcgggaacg   180
aaagagggtg acttatcaga aaaaccagga gacaccgttc tcactcaagc gaaacctgag   240
ggcgttactg gaaatacgaa ttcacttccg acacctacag aaagaactga agtgagcgag   300
gaaacaagcc cttctagtct ggatacactt tttgaaaaag atgaagaagc tcaaaaaaat   360
ccagagctaa cagatgtctt aaaagaaact gtagatacag ctgatgtgga tgggacacaa   420
gcaagtccag cagaaactac tcctgaacaa gtaaaaggtg gagtgaaaga aaatacaaaa   480
gacagcatcg atgttcctgc tgcttatctt gaaaaagctg aagggaaagg tcctttcact   540
gccggtgtaa accaagtaat tccttatgaa ctattcgctg gtgatggtat gttaactcgt   600
ctattactaa aagcttcgga taatgctcct tggtctgaca atggtactgc taaaaatcct   660
gctttacctc ctcttgaagg attaacaaaa gggaaatact tctatgaagt agacttaaat   720
ggcaatactg ttggtaaaca aggtcaagct ttaattgatc aacttcgcgc taatggtact   780
caaacttata aagctactgt taaagtttac ggaaataaag acggtaaagc tgacttgact   840
aatctagttg ctactaaaaa tgtagacatc aacatcaatg gattagttgc taaagaaaca   900
gttcaaaaag ccgttgcaga caacgttaaa gacagtatcg atgttccagc agcctaccta   960
gaaaaagcca agggtgaagg tccattcaca gcaggtgtca accatgtgat tccatacgaa   1020
ctcttcgcag gtgatggcat gttgactcgt ctcttgctca aggcatctga caaggcacca   1080
tggtcagata acggcgacgc taaaaaccca gccctatctc cactaggcga aaacgtgaag   1140
accaaaggtc aatacttcta tcaagtagcc ttggacggaa atgtagctgg caaagaaaaa   1200
caagcgctca ttgaccagtt ccgagcaaat ggtactcaaa cttacagcgc tacagtcaat   1260
gtctatggta acaaagacgg taaaccagac ttggacaaca tcgtagcaac taaaaaagtc   1320
actattaaca taaacggttt aatttctaaa gaaacagttc aaaaagccgt tgcagacaac   1380
gttaaagaca gtatcgatgt tccagcagcc tacctagaaa aagccaaggg tgaaggtcca   1440
ttcacagcag gtgtcaacca tgtgattcca tacgaactct tcgcaggtga tggtatgttg   1500
actcgtctct tgctcaaggc atctgacaag gcaccatggt cagataacgg tgacgctaaa   1560
aacccagccc tatctccact aggtgaaaac gtgaagacca aaggtcaata cttctatcaa   1620
ttagccttgg acggaaatgt agctggcaaa gaaaaacaag cgctcattga ccagttccga   1680
gcaaacggta ctcaaactta cagcgctaca gtcaatgtct atggtaacaa agacggtaaa   1740
ccagacttgg acaacatcgt agcaactaaa aaagtcacta ttaacataaa cggtttaatt   1800
tctaaagaaa cagttcaaaa agccgttgca gacaacgtta aggacagtat cgatgttcca   1860
gcagcctacc tagaaaaggc caagggtgaa ggtccattca cagcaggtgt caaccatgtg   1920
attccatacg aactcttcgc aggtgatggc atgttgactc gtctcttgct caaggcatct   1980
gacaaggcac catggtcaga taacggcgac gctaaaaacc cagctctatc tccactaggt   2040
gaaaacgtga agaccaaagg tcaatacttc tatcaagtag ccttggacgg aaatgtagct   2100
ggcaaagaaa aacaagcgct cattgaccag ttccgagcaa acggtactca aacttacagc   2160
gctacagtca atgtctatgg taacaaagac ggtaaaccag acttggacaa catcgtagca   2220
actaaaaaag tcactattaa gataaatgtt aaagaaacat cagacacagc aaatggttca   2280
ttatcacctt ctaactctgg ttctggcgtg actccgatga atcacaatca tgctacaggt   2340
actacagata gcatgcctgc tgacaccatg acaagttcta ccaacacgat ggcaggtgaa   2400
aacatggctg cttctgctaa caagatgtct gatacgatga tgtcagagga taaagctatg   2460
ctaccaaata ctggtgagac tcaaacatca atggcaagta ttggtttcct tgggcttgcg   2520
cttgcaggtt tactcggtgg tctaggtttg aaaaacaaaa aagaagaaaa c            2571

<210>   4884
<211>   857
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   cell wall surface anchor family protein
<223>   Cellular location: Peptidoglycan-bound (LPXTG)
<223>   Similar to strain R6 sequence 15902119 (0.E+01)

<400>   4884
Met Lys Phe Asn Pro Asn Gln Arg Tyr Thr Arg Trp Ser Ile Arg Arg 
1               5                   10                  15      

Leu Ser Val Gly Val Ala Ser Val Val Val Ala Ser Gly Phe Phe Val 
            20                  25                  30          

Leu Val Gly Gln Pro Ser Ser Val Arg Ala Asp Gly Leu Asn Pro Thr 
        35                  40                  45              

Pro Gly Gln Val Leu Pro Glu Glu Thr Ser Gly Thr Lys Glu Gly Asp 
    50                  55                  60                  

Leu Ser Glu Lys Pro Gly Asp Thr Val Leu Thr Gln Ala Lys Pro Glu 
65                  70                  75                  80  

Gly Val Thr Gly Asn Thr Asn Ser Leu Pro Thr Pro Thr Glu Arg Thr 
                85                  90                  95      

Glu Val Ser Glu Glu Thr Ser Pro Ser Ser Leu Asp Thr Leu Phe Glu 
            100                 105                 110         

Lys Asp Glu Glu Ala Gln Lys Asn Pro Glu Leu Thr Asp Val Leu Lys 
        115                 120                 125             

Glu Thr Val Asp Thr Ala Asp Val Asp Gly Thr Gln Ala Ser Pro Ala 
    130                 135                 140                 

Glu Thr Thr Pro Glu Gln Val Lys Gly Gly Val Lys Glu Asn Thr Lys 
145                 150                 155                 160 

Asp Ser Ile Asp Val Pro Ala Ala Tyr Leu Glu Lys Ala Glu Gly Lys 
                165                 170                 175     

Gly Pro Phe Thr Ala Gly Val Asn Gln Val Ile Pro Tyr Glu Leu Phe 
            180                 185                 190         

Ala Gly Asp Gly Met Leu Thr Arg Leu Leu Leu Lys Ala Ser Asp Asn 
        195                 200                 205             

Ala Pro Trp Ser Asp Asn Gly Thr Ala Lys Asn Pro Ala Leu Pro Pro 
    210                 215                 220                 

Leu Glu Gly Leu Thr Lys Gly Lys Tyr Phe Tyr Glu Val Asp Leu Asn 
225                 230                 235                 240 

Gly Asn Thr Val Gly Lys Gln Gly Gln Ala Leu Ile Asp Gln Leu Arg 
                245                 250                 255     

Ala Asn Gly Thr Gln Thr Tyr Lys Ala Thr Val Lys Val Tyr Gly Asn 
            260                 265                 270         

Lys Asp Gly Lys Ala Asp Leu Thr Asn Leu Val Ala Thr Lys Asn Val 
        275                 280                 285             

Asp Ile Asn Ile Asn Gly Leu Val Ala Lys Glu Thr Val Gln Lys Ala 
    290                 295                 300                 

Val Ala Asp Asn Val Lys Asp Ser Ile Asp Val Pro Ala Ala Tyr Leu 
305                 310                 315                 320 

Glu Lys Ala Lys Gly Glu Gly Pro Phe Thr Ala Gly Val Asn His Val 
                325                 330                 335     

Ile Pro Tyr Glu Leu Phe Ala Gly Asp Gly Met Leu Thr Arg Leu Leu 
            340                 345                 350         

Leu Lys Ala Ser Asp Lys Ala Pro Trp Ser Asp Asn Gly Asp Ala Lys 
        355                 360                 365             

Asn Pro Ala Leu Ser Pro Leu Gly Glu Asn Val Lys Thr Lys Gly Gln 
    370                 375                 380                 

Tyr Phe Tyr Gln Val Ala Leu Asp Gly Asn Val Ala Gly Lys Glu Lys 
385                 390                 395                 400 

Gln Ala Leu Ile Asp Gln Phe Arg Ala Asn Gly Thr Gln Thr Tyr Ser 
                405                 410                 415     

Ala Thr Val Asn Val Tyr Gly Asn Lys Asp Gly Lys Pro Asp Leu Asp 
            420                 425                 430         

Asn Ile Val Ala Thr Lys Lys Val Thr Ile Asn Ile Asn Gly Leu Ile 
        435                 440                 445             

Ser Lys Glu Thr Val Gln Lys Ala Val Ala Asp Asn Val Lys Asp Ser 
    450                 455                 460                 

Ile Asp Val Pro Ala Ala Tyr Leu Glu Lys Ala Lys Gly Glu Gly Pro 
465                 470                 475                 480 

Phe Thr Ala Gly Val Asn His Val Ile Pro Tyr Glu Leu Phe Ala Gly 
                485                 490                 495     

Asp Gly Met Leu Thr Arg Leu Leu Leu Lys Ala Ser Asp Lys Ala Pro 
            500                 505                 510         

Trp Ser Asp Asn Gly Asp Ala Lys Asn Pro Ala Leu Ser Pro Leu Gly 
        515                 520                 525             

Glu Asn Val Lys Thr Lys Gly Gln Tyr Phe Tyr Gln Leu Ala Leu Asp 
    530                 535                 540                 

Gly Asn Val Ala Gly Lys Glu Lys Gln Ala Leu Ile Asp Gln Phe Arg 
545                 550                 555                 560 

Ala Asn Gly Thr Gln Thr Tyr Ser Ala Thr Val Asn Val Tyr Gly Asn 
                565                 570                 575     

Lys Asp Gly Lys Pro Asp Leu Asp Asn Ile Val Ala Thr Lys Lys Val 
            580                 585                 590         

Thr Ile Asn Ile Asn Gly Leu Ile Ser Lys Glu Thr Val Gln Lys Ala 
        595                 600                 605             

Val Ala Asp Asn Val Lys Asp Ser Ile Asp Val Pro Ala Ala Tyr Leu 
    610                 615                 620                 

Glu Lys Ala Lys Gly Glu Gly Pro Phe Thr Ala Gly Val Asn His Val 
625                 630                 635                 640 

Ile Pro Tyr Glu Leu Phe Ala Gly Asp Gly Met Leu Thr Arg Leu Leu 
                645                 650                 655     

Leu Lys Ala Ser Asp Lys Ala Pro Trp Ser Asp Asn Gly Asp Ala Lys 
            660                 665                 670         

Asn Pro Ala Leu Ser Pro Leu Gly Glu Asn Val Lys Thr Lys Gly Gln 
        675                 680                 685             

Tyr Phe Tyr Gln Val Ala Leu Asp Gly Asn Val Ala Gly Lys Glu Lys 
    690                 695                 700                 

Gln Ala Leu Ile Asp Gln Phe Arg Ala Asn Gly Thr Gln Thr Tyr Ser 
705                 710                 715                 720 

Ala Thr Val Asn Val Tyr Gly Asn Lys Asp Gly Lys Pro Asp Leu Asp 
                725                 730                 735     

Asn Ile Val Ala Thr Lys Lys Val Thr Ile Lys Ile Asn Val Lys Glu 
            740                 745                 750         

Thr Ser Asp Thr Ala Asn Gly Ser Leu Ser Pro Ser Asn Ser Gly Ser 
        755                 760                 765             

Gly Val Thr Pro Met Asn His Asn His Ala Thr Gly Thr Thr Asp Ser 
    770                 775                 780                 

Met Pro Ala Asp Thr Met Thr Ser Ser Thr Asn Thr Met Ala Gly Glu 
785                 790                 795                 800 

Asn Met Ala Ala Ser Ala Asn Lys Met Ser Asp Thr Met Met Ser Glu 
                805                 810                 815     

Asp Lys Ala Met Leu Pro Asn Thr Gly Glu Thr Gln Thr Ser Met Ala 
            820                 825                 830         

Ser Ile Gly Phe Leu Gly Leu Ala Leu Ala Gly Leu Leu Gly Gly Leu 
        835                 840                 845             

Gly Leu Lys Asn Lys Lys Glu Glu Asn 
    850                 855         

<210>   4885
<211>   696
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4885
atgggaaaga caattttact cgttgacgac gaggtagaaa tcacagatat tcatcagaga   60
tacttaattc aggcaggtta tcaggtcttg gtagcccatg atggactgga agcgctagag   120
ctgttcaaga aaaaaccgat tgatttgatt atcacagatg tcatgatgcc tcggatggat   180
ggttatgatt taatcagtga ggttcaatac ttatcaccag agcagccttt cctatttatt   240
actgctaaga ccagtgaaca ggacaagatt tacggcctga gcttgggagc agatgatttt   300
attgctaagc cttttagccc acgtgagctg gttttgcgtg tccacaatat tttgcgccgc   360
cttcatcgtg ggggcgaaac agagctgatt tcccttggca atctaaaaat gaatcatagt   420
agtcatgaag ttcaaatagg agaagaaatg ctggatttaa ctgttaaatc atttgaattg   480
ctgtggattt tagctagtaa tccagagcga gttttctcca agacagacct ctatgaaaag   540
atctggaaag aagactacgt ggatgacacc aataccttga atgtgcatat ccatgctctt   600
cgacaggagc tggcaaaata tagtagtgac caaactccca ctattaagac agtttggggg   660
ttgggatata agatagagaa accgagagga caaaca                             696

<210>   4886
<211>   232
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   DNA-binding response regulator
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902120 (e-130)

<400>   4886
Met Gly Lys Thr Ile Leu Leu Val Asp Asp Glu Val Glu Ile Thr Asp 
1               5                   10                  15      

Ile His Gln Arg Tyr Leu Ile Gln Ala Gly Tyr Gln Val Leu Val Ala 
            20                  25                  30          

His Asp Gly Leu Glu Ala Leu Glu Leu Phe Lys Lys Lys Pro Ile Asp 
        35                  40                  45              

Leu Ile Ile Thr Asp Val Met Met Pro Arg Met Asp Gly Tyr Asp Leu 
    50                  55                  60                  

Ile Ser Glu Val Gln Tyr Leu Ser Pro Glu Gln Pro Phe Leu Phe Ile 
65                  70                  75                  80  

Thr Ala Lys Thr Ser Glu Gln Asp Lys Ile Tyr Gly Leu Ser Leu Gly 
                85                  90                  95      

Ala Asp Asp Phe Ile Ala Lys Pro Phe Ser Pro Arg Glu Leu Val Leu 
            100                 105                 110         

Arg Val His Asn Ile Leu Arg Arg Leu His Arg Gly Gly Glu Thr Glu 
        115                 120                 125             

Leu Ile Ser Leu Gly Asn Leu Lys Met Asn His Ser Ser His Glu Val 
    130                 135                 140                 

Gln Ile Gly Glu Glu Met Leu Asp Leu Thr Val Lys Ser Phe Glu Leu 
145                 150                 155                 160 

Leu Trp Ile Leu Ala Ser Asn Pro Glu Arg Val Phe Ser Lys Thr Asp 
                165                 170                 175     

Leu Tyr Glu Lys Ile Trp Lys Glu Asp Tyr Val Asp Asp Thr Asn Thr 
            180                 185                 190         

Leu Asn Val His Ile His Ala Leu Arg Gln Glu Leu Ala Lys Tyr Ser 
        195                 200                 205             

Ser Asp Gln Thr Pro Thr Ile Lys Thr Val Trp Gly Leu Gly Tyr Lys 
    210                 215                 220                 

Ile Glu Lys Pro Arg Gly Gln Thr 
225                 230         

<210>   4887
<211>   1050
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4887
atgaaactaa aaagttatat tttggttgga tatattattt caaccctctt aaccattttg   60
gttgtttttt gggctgttca aaaaatgctg attgcgaaag gcgagattta ctttttgctt   120
gggatgacca tcgttgccag ccttgtcggt gctgggatta gtctctttct cctattgcca   180
gtctttacgt cgttgggcaa actcaaggag catgccaagc gggtagcggc caaggatttt   240
ccttcaaatt tggaggttca aggtcctgta gaatttcagc aattagggca aacttttaat   300
gagatgtccc atgatttgca ggtaagcttt gattccttgg aagaaagcga acgagaaaag   360
ggcttgatga ttgcccagtt gtcgcatgat attaagactc ctatcacttc gatccaagcg   420
acggtagaag ggattttgga tgggattatc aaggagtcgg agcaagctca ttatctagca   480
accattggac gccagacgga gaggctcaat aaactggttg aggagttgaa ttttttgacc   540
ctaaacacag ctagaaatca ggtggaaact accagtaaag acagtatttt tctggacaag   600
ctcttaattg agtgcatgag tgaatttcag tttttgattg agcaggagag aagagatgtc   660
cacttgcagg taatcccaga gtctgcccgg attgagggag attatgctaa gctttctcgt   720
atcttggtga atctggtcga taacgctttt aaatattctg ctccaggaac caagctggaa   780
gtggtggcta agctggagaa ggaccagctt tcaatcagtg tgaccgatga agggcagggt   840
attgccccag aggatttgga aaatattttc aaacgccttt atcgtgtcga aacttcgcgt   900
aacatgaaga caggtggtca tggattagga cttgcgattg cgcgtgaatt ggcccatcaa   960
ttgggtgggg aaatcacagt cagcagccag tacggtctag gaagtacctt taccctcgtt   1020
ctcaacctct ctggtagtga aaataaagcc                                    1050

<210>   4888
<211>   350
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   sensor histidine kinase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902121 (0.E+01)

<400>   4888
Met Lys Leu Lys Ser Tyr Ile Leu Val Gly Tyr Ile Ile Ser Thr Leu 
1               5                   10                  15      

Leu Thr Ile Leu Val Val Phe Trp Ala Val Gln Lys Met Leu Ile Ala 
            20                  25                  30          

Lys Gly Glu Ile Tyr Phe Leu Leu Gly Met Thr Ile Val Ala Ser Leu 
        35                  40                  45              

Val Gly Ala Gly Ile Ser Leu Phe Leu Leu Leu Pro Val Phe Thr Ser 
    50                  55                  60                  

Leu Gly Lys Leu Lys Glu His Ala Lys Arg Val Ala Ala Lys Asp Phe 
65                  70                  75                  80  

Pro Ser Asn Leu Glu Val Gln Gly Pro Val Glu Phe Gln Gln Leu Gly 
                85                  90                  95      

Gln Thr Phe Asn Glu Met Ser His Asp Leu Gln Val Ser Phe Asp Ser 
            100                 105                 110         

Leu Glu Glu Ser Glu Arg Glu Lys Gly Leu Met Ile Ala Gln Leu Ser 
        115                 120                 125             

His Asp Ile Lys Thr Pro Ile Thr Ser Ile Gln Ala Thr Val Glu Gly 
    130                 135                 140                 

Ile Leu Asp Gly Ile Ile Lys Glu Ser Glu Gln Ala His Tyr Leu Ala 
145                 150                 155                 160 

Thr Ile Gly Arg Gln Thr Glu Arg Leu Asn Lys Leu Val Glu Glu Leu 
                165                 170                 175     

Asn Phe Leu Thr Leu Asn Thr Ala Arg Asn Gln Val Glu Thr Thr Ser 
            180                 185                 190         

Lys Asp Ser Ile Phe Leu Asp Lys Leu Leu Ile Glu Cys Met Ser Glu 
        195                 200                 205             

Phe Gln Phe Leu Ile Glu Gln Glu Arg Arg Asp Val His Leu Gln Val 
    210                 215                 220                 

Ile Pro Glu Ser Ala Arg Ile Glu Gly Asp Tyr Ala Lys Leu Ser Arg 
225                 230                 235                 240 

Ile Leu Val Asn Leu Val Asp Asn Ala Phe Lys Tyr Ser Ala Pro Gly 
                245                 250                 255     

Thr Lys Leu Glu Val Val Ala Lys Leu Glu Lys Asp Gln Leu Ser Ile 
            260                 265                 270         

Ser Val Thr Asp Glu Gly Gln Gly Ile Ala Pro Glu Asp Leu Glu Asn 
        275                 280                 285             

Ile Phe Lys Arg Leu Tyr Arg Val Glu Thr Ser Arg Asn Met Lys Thr 
    290                 295                 300                 

Gly Gly His Gly Leu Gly Leu Ala Ile Ala Arg Glu Leu Ala His Gln 
305                 310                 315                 320 

Leu Gly Gly Glu Ile Thr Val Ser Ser Gln Tyr Gly Leu Gly Ser Thr 
                325                 330                 335     

Phe Thr Leu Val Leu Asn Leu Ser Gly Ser Glu Asn Lys Ala 
            340                 345                 350 

<210>   4889
<211>   609
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4889
atgtcacgtt atacaggacc atcttggaaa caagctcgtc gtcttggcct ttcacttaca   60
ggtacaggta aagaattggc acgtcgtaac tacgtaccag gacaacacgg accaaacaac   120
cgttctaaat tgtcagaata cggtttgcaa ttggctgaaa aacaaaaact tcgtttcact   180
tacggtgtag gtgaaaaaca attccgtaac ttgttcgtac aagctacaaa aatcaaaggc   240
ggaatcctag gtttcaactt tatgcttctt ttggaacgtc gtttggataa cgttgtttac   300
cgtcttggtc tcgcgactac tcgtcgtcaa gctcgtcaat tcgtaaacca cggtcacatc   360
cttgttgacg ggaaacgcgt tgatatccca tcataccgcg taactccagg tcaagtgatc   420
tcagttcgtg aaaaatcatt gaaagttcca gcaatccttg aagcagtaga agctactctt   480
ggacgtccag cattcgtatc attcgacgct gaaaaattgg aaggttcatt gactcgcttg   540
ccagaacgcg acgaaatcaa cccagaaatc aacgaagcac ttgtcgttga attctacaac   600
aaaatgttg                                                           609

<210>   4890
<211>   203
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein S4 (rpsD)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902122 (e-114)

<400>   4890
Met Ser Arg Tyr Thr Gly Pro Ser Trp Lys Gln Ala Arg Arg Leu Gly 
1               5                   10                  15      

Leu Ser Leu Thr Gly Thr Gly Lys Glu Leu Ala Arg Arg Asn Tyr Val 
            20                  25                  30          

Pro Gly Gln His Gly Pro Asn Asn Arg Ser Lys Leu Ser Glu Tyr Gly 
        35                  40                  45              

Leu Gln Leu Ala Glu Lys Gln Lys Leu Arg Phe Thr Tyr Gly Val Gly 
    50                  55                  60                  

Glu Lys Gln Phe Arg Asn Leu Phe Val Gln Ala Thr Lys Ile Lys Gly 
65                  70                  75                  80  

Gly Ile Leu Gly Phe Asn Phe Met Leu Leu Leu Glu Arg Arg Leu Asp 
                85                  90                  95      

Asn Val Val Tyr Arg Leu Gly Leu Ala Thr Thr Arg Arg Gln Ala Arg 
            100                 105                 110         

Gln Phe Val Asn His Gly His Ile Leu Val Asp Gly Lys Arg Val Asp 
        115                 120                 125             

Ile Pro Ser Tyr Arg Val Thr Pro Gly Gln Val Ile Ser Val Arg Glu 
    130                 135                 140                 

Lys Ser Leu Lys Val Pro Ala Ile Leu Glu Ala Val Glu Ala Thr Leu 
145                 150                 155                 160 

Gly Arg Pro Ala Phe Val Ser Phe Asp Ala Glu Lys Leu Glu Gly Ser 
                165                 170                 175     

Leu Thr Arg Leu Pro Glu Arg Asp Glu Ile Asn Pro Glu Ile Asn Glu 
            180                 185                 190         

Ala Leu Val Val Glu Phe Tyr Asn Lys Met Leu 
        195                 200             

<210>   4891
<211>   138
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4891
atgaaatcaa ctaaagaaga aatccaaacc atcaaaacac ttttaaaaga ctctcgtaca   60
gctaaatatc ataaacgcct tcaaatcgtt ctattttgtc tgatgggcaa atcttataaa   120
gagattatag aactttta                                                 138

<210>   4892
<211>   46
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4892
Met Lys Ser Thr Lys Glu Glu Ile Gln Thr Ile Lys Thr Leu Leu Lys 
1               5                   10                  15      

Asp Ser Arg Thr Ala Lys Tyr His Lys Arg Leu Gln Ile Val Leu Phe 
            20                  25                  30          

Cys Leu Met Gly Lys Ser Tyr Lys Glu Ile Ile Glu Leu Leu 
        35                  40                  45      

<210>   4893
<211>   267
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4893
ttgagatcat tgacaggtgt atcgaatcct accacagatt cagcacgtct ggttttggca   60
gaggctaata aagcttttgc agatgatagt ttgacagagc aaggtttacg tgatatcttg   120
caaacagtca aagatgccat tgcttcccta gagtccatta aggaaagcca gtcagcaact   180
aaggatggag gacaaacagc gggcaaagaa acagcaggag aagatgagtc tgcaaatcaa   240
actcaagaaa ttagccaagg aattaag                                       267

<210>   4894
<211>   89
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902124 (1.E-44)

<400>   4894
Met Arg Ser Leu Thr Gly Val Ser Asn Pro Thr Thr Asp Ser Ala Arg 
1               5                   10                  15      

Leu Val Leu Ala Glu Ala Asn Lys Ala Phe Ala Asp Asp Ser Leu Thr 
            20                  25                  30          

Glu Gln Gly Leu Arg Asp Ile Leu Gln Thr Val Lys Asp Ala Ile Ala 
        35                  40                  45              

Ser Leu Glu Ser Ile Lys Glu Ser Gln Ser Ala Thr Lys Asp Gly Gly 
    50                  55                  60                  

Gln Thr Ala Gly Lys Glu Thr Ala Gly Glu Asp Glu Ser Ala Asn Gln 
65                  70                  75                  80  

Thr Gln Glu Ile Ser Gln Gly Ile Lys 
                85                  

<210>   4895
<211>   93
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4895
ttgttcttgg cagatgaaaa aggctctgag catactgcag cagagttgat tgataatctt   60
aaagaggtta ttgctaagtt gaaagcaaac gcc                                93

<210>   4896
<211>   31
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4896
Met Phe Leu Ala Asp Glu Lys Gly Ser Glu His Thr Ala Ala Glu Leu 
1               5                   10                  15      

Ile Asp Asn Leu Lys Glu Val Ile Ala Lys Leu Lys Ala Asn Ala 
            20                  25                  30      

<210>   4897
<211>   957
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4897
atggatatca aaataaaaag ggaggaaatt atgaaaaagt tttcaaaaac attgagagac   60
aactggatct ttctcttgat ggttttgcca ggggcactct ggttgattct attcttttac   120
attccagtat ttgggaacgt ggttgccttc aaagactacc acatgaccag taatggtttc   180
atagatagta tcataaatag taaatgggtc ggactcgata attttagatt cttatttagt   240
tcaagagacg cctttattat cacacgaaat actgtcctct acaatcttgg ctttatcttt   300
ctaggtttag ttgtatctgt agggattgcc attatcctca gcgagctccg ttctaagaga   360
atggtgaaga tttttcaaac ttctatgttg ttcccttact tcttgtcttg ggttatcatc   420
agtttcttta cagatgcctt cctaaatatt gataaagggg tgttcaatca tctattggaa   480
agtcttggtc tcaaagaagt caatttctac gctgacctgg gcatctggcc ctatctccta   540
cttttcctag gtatttggaa aggctttgga tatagcagtg tcatgtacta tgcgacgatc   600
atgggaattg atccaaccta ctacgaagca gcgacagtgg acggagctag caagtggcaa   660
cgtattcgca acgtaaccat tcctcagttg actccgcttg taactgtatt gaccatcctt   720
gcagtcggaa atatcttccg cgcagacttc ggtctcttct atcaaatccc acacaatgct   780
ggtcagcttt acaatgtaac caacgttttg gacgtatatg tctttaatgg tttgactcag   840
acagcagata tcggtatggc tgcagcagcc ggtctttacc aatccgttgt tggtttgatt   900
ctggttatcc tatcaaactt gcttgcaaga cgagtcgatc caaactcagc tttgttc      957

<210>   4898
<211>   319
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902125 (0.E+01)

<400>   4898
Met Asp Ile Lys Ile Lys Arg Glu Glu Ile Met Lys Lys Phe Ser Lys 
1               5                   10                  15      

Thr Leu Arg Asp Asn Trp Ile Phe Leu Leu Met Val Leu Pro Gly Ala 
            20                  25                  30          

Leu Trp Leu Ile Leu Phe Phe Tyr Ile Pro Val Phe Gly Asn Val Val 
        35                  40                  45              

Ala Phe Lys Asp Tyr His Met Thr Ser Asn Gly Phe Ile Asp Ser Ile 
    50                  55                  60                  

Ile Asn Ser Lys Trp Val Gly Leu Asp Asn Phe Arg Phe Leu Phe Ser 
65                  70                  75                  80  

Ser Arg Asp Ala Phe Ile Ile Thr Arg Asn Thr Val Leu Tyr Asn Leu 
                85                  90                  95      

Gly Phe Ile Phe Leu Gly Leu Val Val Ser Val Gly Ile Ala Ile Ile 
            100                 105                 110         

Leu Ser Glu Leu Arg Ser Lys Arg Met Val Lys Ile Phe Gln Thr Ser 
        115                 120                 125             

Met Leu Phe Pro Tyr Phe Leu Ser Trp Val Ile Ile Ser Phe Phe Thr 
    130                 135                 140                 

Asp Ala Phe Leu Asn Ile Asp Lys Gly Val Phe Asn His Leu Leu Glu 
145                 150                 155                 160 

Ser Leu Gly Leu Lys Glu Val Asn Phe Tyr Ala Asp Leu Gly Ile Trp 
                165                 170                 175     

Pro Tyr Leu Leu Leu Phe Leu Gly Ile Trp Lys Gly Phe Gly Tyr Ser 
            180                 185                 190         

Ser Val Met Tyr Tyr Ala Thr Ile Met Gly Ile Asp Pro Thr Tyr Tyr 
        195                 200                 205             

Glu Ala Ala Thr Val Asp Gly Ala Ser Lys Trp Gln Arg Ile Arg Asn 
    210                 215                 220                 

Val Thr Ile Pro Gln Leu Thr Pro Leu Val Thr Val Leu Thr Ile Leu 
225                 230                 235                 240 

Ala Val Gly Asn Ile Phe Arg Ala Asp Phe Gly Leu Phe Tyr Gln Ile 
                245                 250                 255     

Pro His Asn Ala Gly Gln Leu Tyr Asn Val Thr Asn Val Leu Asp Val 
            260                 265                 270         

Tyr Val Phe Asn Gly Leu Thr Gln Thr Ala Asp Ile Gly Met Ala Ala 
        275                 280                 285             

Ala Ala Gly Leu Tyr Gln Ser Val Val Gly Leu Ile Leu Val Ile Leu 
    290                 295                 300                 

Ser Asn Leu Leu Ala Arg Arg Val Asp Pro Asn Ser Ala Leu Phe 
305                 310                 315                 

<210>   4899
<211>   972
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4899
ttgcaagacg agtcgatcca aactcagctt tgttctagaa aggaggagaa tatggcaaaa   60
aagaaaatta aaaaagaaaa aattgataat gtcggcattc actccttcag taagaaagca   120
gatatcttct tcagtatcat ttcgggtttg attgccctct cttgtatcct accttttgta   180
ttcgttatca ttatttcagt gacagacgag aaaagcctcc tccaatacgg ctatagcttc   240
ttcccatccc aatttggctt agacggtttt gagtttttgg cacagtttaa ggataaaatc   300
ctacaagccc tcttcatctc tgtctttgta accgtagttg ggacattgac aaatgtcttt   360
atcacaacaa cctatgccta cgctatttca cggacaacct ttaagtatcg cagattcttt   420
accatcttcg tccttctcag tatgttgttc aacgctggtt tggtaccagg ttatatcatg   480
gtgacccgtg tacttcagct tggtgacact gtttgggcct tgattgttcc aatgcttctc   540
tcaccattta acatcatctt gatgcgttcc ttcttcaaga agaccattcc agaagccatt   600
ctagaatcgg ctcgtatcga tggtgccagt gaggcccgga ttttcttcca aatctgtttg   660
ccattgtcac taccaggtat cgcaaccatc acgctcttaa cagctcttgg tttctggaat   720
gactggttca acgcccttct ttacatcaag agtgacaact tgtatccatt gcaatatttg   780
ctcatgcaaa tccaacaaaa tatggactac attgccaaag cggtcggctt gattggtcaa   840
ctgggagttg ctctaccgaa agaaacaggt cgtatggcca tggttgtggt tgcaaccctt   900
ccaatcgcga ttttgtatcc atttttccaa cgctactttg taaaaggttt gactatcggt   960
ggtgtgaaag aa                                                       972

<210>   4900
<211>   324
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, permease protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902126 (e-172)

<400>   4900
Met Gln Asp Glu Ser Ile Gln Thr Gln Leu Cys Ser Arg Lys Glu Glu 
1               5                   10                  15      

Asn Met Ala Lys Lys Lys Ile Lys Lys Glu Lys Ile Asp Asn Val Gly 
            20                  25                  30          

Ile His Ser Phe Ser Lys Lys Ala Asp Ile Phe Phe Ser Ile Ile Ser 
        35                  40                  45              

Gly Leu Ile Ala Leu Ser Cys Ile Leu Pro Phe Val Phe Val Ile Ile 
    50                  55                  60                  

Ile Ser Val Thr Asp Glu Lys Ser Leu Leu Gln Tyr Gly Tyr Ser Phe 
65                  70                  75                  80  

Phe Pro Ser Gln Phe Gly Leu Asp Gly Phe Glu Phe Leu Ala Gln Phe 
                85                  90                  95      

Lys Asp Lys Ile Leu Gln Ala Leu Phe Ile Ser Val Phe Val Thr Val 
            100                 105                 110         

Val Gly Thr Leu Thr Asn Val Phe Ile Thr Thr Thr Tyr Ala Tyr Ala 
        115                 120                 125             

Ile Ser Arg Thr Thr Phe Lys Tyr Arg Arg Phe Phe Thr Ile Phe Val 
    130                 135                 140                 

Leu Leu Ser Met Leu Phe Asn Ala Gly Leu Val Pro Gly Tyr Ile Met 
145                 150                 155                 160 

Val Thr Arg Val Leu Gln Leu Gly Asp Thr Val Trp Ala Leu Ile Val 
                165                 170                 175     

Pro Met Leu Leu Ser Pro Phe Asn Ile Ile Leu Met Arg Ser Phe Phe 
            180                 185                 190         

Lys Lys Thr Ile Pro Glu Ala Ile Leu Glu Ser Ala Arg Ile Asp Gly 
        195                 200                 205             

Ala Ser Glu Ala Arg Ile Phe Phe Gln Ile Cys Leu Pro Leu Ser Leu 
    210                 215                 220                 

Pro Gly Ile Ala Thr Ile Thr Leu Leu Thr Ala Leu Gly Phe Trp Asn 
225                 230                 235                 240 

Asp Trp Phe Asn Ala Leu Leu Tyr Ile Lys Ser Asp Asn Leu Tyr Pro 
                245                 250                 255     

Leu Gln Tyr Leu Leu Met Gln Ile Gln Gln Asn Met Asp Tyr Ile Ala 
            260                 265                 270         

Lys Ala Val Gly Leu Ile Gly Gln Leu Gly Val Ala Leu Pro Lys Glu 
        275                 280                 285             

Thr Gly Arg Met Ala Met Val Val Val Ala Thr Leu Pro Ile Ala Ile 
    290                 295                 300                 

Leu Tyr Pro Phe Phe Gln Arg Tyr Phe Val Lys Gly Leu Thr Ile Gly 
305                 310                 315                 320 

Gly Val Lys Glu 
                

<210>   4901
<211>   1473
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4901
atgaaaaact ggaaaaaata tgcttttgca tctgctagtg tagtcgctct ggctgcaggt   60
cttgctgctt gtggaaattt gacaggtaac agcaaaaaag ctgctgattc aggtgacaaa   120
cctgttatca aaatgtacca aatcggtgac aaaccagaca acttggatga attgttagca   180
aatgccaaca aaatcattga agaaaaagtt ggtgccaaat tggatatcca ataccttggc   240
tggggtgact atggtaagaa aatgtcagtt atcacatcat ctggtgaaaa ctatgatatt   300
gcctttgcag ataactatat tgtaaatgct caaaaaggtg cttacgctga cttgacagaa   360
ttgtacaaaa aagaaggtaa agacctttac aaagcacttg acccagctta catcaagggt   420
aatactgtaa atggtaagat ttacgctgtt ccagttgcag ccaacgttgc atcatctcaa   480
aactttgcct tcaacggaac tctccttgct aaatatggta tcgatatttc aggtgttact   540
tcttacgaaa ctcttgagcc agtcttgaaa caaatcaaag aaaaagctcc agacgtagta   600
ccatttgcta ttggtaaagt tttcatccca tctgataatt ttgactaccc agtagcaaac   660
ggtcttccat tcgttatcga ccttgaaggc gatactacta aagttgtaaa ccgttacgaa   720
gtgcctcgtt tcaaagaaca cttgaagact cttcacaaat tctatgaagc tggctacatt   780
ccaaaagacg tcgcaacaag cgatacttcc tttgaccttc aacaagatac ttggttcgtt   840
cgtgaagaaa cagtaggacc agctgactac ggtaacagct tgctttcacg tgttgccaac   900
aaagatatcc aaatcaaacc aattactaac ttcatcaaga aaaaccaaac aacacaagtt   960
gctaactttg tcatctcaaa caactctaag aacaaagaaa aatcaatgga aatcttgaac   1020
ctcttgaata cgaacccaga actcttgaac ggtcttgttt acggtccaga aggcaagaac   1080
tgggaaaaaa ttgaaggtaa agaaaaccgt gttcgcgttc ttgatggcta caaaggaaac   1140
actcacatgg gtggatggaa cactggtaac aactggatcc tttacatcaa cgaaaacgtt   1200
acagaccaac aaatcgaaaa ttctaagaaa gaattggcag aagctaaaga atctccagcg   1260
cttggattta tcttcaatac tgacaatgtg aaatctgaaa tctcagctat tgctaacaca   1320
atgcaacaat ttgatacagc tatcaacact ggtactgtag acccagataa agcgattcca   1380
gaattgatgg aaaaattgaa atctgaaggt gcctacgaaa aagtattgaa cgaaatgcaa   1440
aaacaatacg atgaattctt gaaaaacaaa aaa                                1473

<210>   4902
<211>   491
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ABC transporter, substrate-binding protein
<223>   Cellular location: lipoprotein
<223>   Similar to strain R6 sequence 15902127 (0.E+01)

<400>   4902
Met Lys Asn Trp Lys Lys Tyr Ala Phe Ala Ser Ala Ser Val Val Ala 
1               5                   10                  15      

Leu Ala Ala Gly Leu Ala Ala Cys Gly Asn Leu Thr Gly Asn Ser Lys 
            20                  25                  30          

Lys Ala Ala Asp Ser Gly Asp Lys Pro Val Ile Lys Met Tyr Gln Ile 
        35                  40                  45              

Gly Asp Lys Pro Asp Asn Leu Asp Glu Leu Leu Ala Asn Ala Asn Lys 
    50                  55                  60                  

Ile Ile Glu Glu Lys Val Gly Ala Lys Leu Asp Ile Gln Tyr Leu Gly 
65                  70                  75                  80  

Trp Gly Asp Tyr Gly Lys Lys Met Ser Val Ile Thr Ser Ser Gly Glu 
                85                  90                  95      

Asn Tyr Asp Ile Ala Phe Ala Asp Asn Tyr Ile Val Asn Ala Gln Lys 
            100                 105                 110         

Gly Ala Tyr Ala Asp Leu Thr Glu Leu Tyr Lys Lys Glu Gly Lys Asp 
        115                 120                 125             

Leu Tyr Lys Ala Leu Asp Pro Ala Tyr Ile Lys Gly Asn Thr Val Asn 
    130                 135                 140                 

Gly Lys Ile Tyr Ala Val Pro Val Ala Ala Asn Val Ala Ser Ser Gln 
145                 150                 155                 160 

Asn Phe Ala Phe Asn Gly Thr Leu Leu Ala Lys Tyr Gly Ile Asp Ile 
                165                 170                 175     

Ser Gly Val Thr Ser Tyr Glu Thr Leu Glu Pro Val Leu Lys Gln Ile 
            180                 185                 190         

Lys Glu Lys Ala Pro Asp Val Val Pro Phe Ala Ile Gly Lys Val Phe 
        195                 200                 205             

Ile Pro Ser Asp Asn Phe Asp Tyr Pro Val Ala Asn Gly Leu Pro Phe 
    210                 215                 220                 

Val Ile Asp Leu Glu Gly Asp Thr Thr Lys Val Val Asn Arg Tyr Glu 
225                 230                 235                 240 

Val Pro Arg Phe Lys Glu His Leu Lys Thr Leu His Lys Phe Tyr Glu 
                245                 250                 255     

Ala Gly Tyr Ile Pro Lys Asp Val Ala Thr Ser Asp Thr Ser Phe Asp 
            260                 265                 270         

Leu Gln Gln Asp Thr Trp Phe Val Arg Glu Glu Thr Val Gly Pro Ala 
        275                 280                 285             

Asp Tyr Gly Asn Ser Leu Leu Ser Arg Val Ala Asn Lys Asp Ile Gln 
    290                 295                 300                 

Ile Lys Pro Ile Thr Asn Phe Ile Lys Lys Asn Gln Thr Thr Gln Val 
305                 310                 315                 320 

Ala Asn Phe Val Ile Ser Asn Asn Ser Lys Asn Lys Glu Lys Ser Met 
                325                 330                 335     

Glu Ile Leu Asn Leu Leu Asn Thr Asn Pro Glu Leu Leu Asn Gly Leu 
            340                 345                 350         

Val Tyr Gly Pro Glu Gly Lys Asn Trp Glu Lys Ile Glu Gly Lys Glu 
        355                 360                 365             

Asn Arg Val Arg Val Leu Asp Gly Tyr Lys Gly Asn Thr His Met Gly 
    370                 375                 380                 

Gly Trp Asn Thr Gly Asn Asn Trp Ile Leu Tyr Ile Asn Glu Asn Val 
385                 390                 395                 400 

Thr Asp Gln Gln Ile Glu Asn Ser Lys Lys Glu Leu Ala Glu Ala Lys 
                405                 410                 415     

Glu Ser Pro Ala Leu Gly Phe Ile Phe Asn Thr Asp Asn Val Lys Ser 
            420                 425                 430         

Glu Ile Ser Ala Ile Ala Asn Thr Met Gln Gln Phe Asp Thr Ala Ile 
        435                 440                 445             

Asn Thr Gly Thr Val Asp Pro Asp Lys Ala Ile Pro Glu Leu Met Glu 
    450                 455                 460                 

Lys Leu Lys Ser Glu Gly Ala Tyr Glu Lys Val Leu Asn Glu Met Gln 
465                 470                 475                 480 

Lys Gln Tyr Asp Glu Phe Leu Lys Asn Lys Lys 
                485                 490     

<210>   4903
<211>   111
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4903
atggttaaaa taaggacaag agaaaacatg gatatctata tccttgtgcc aaaaaaacca   60
ctgccctccc cagaccaacc tgaggaaagc agtgattctt attttaggag t            111

<210>   4904
<211>   37
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4904
Met Val Lys Ile Arg Thr Arg Glu Asn Met Asp Ile Tyr Ile Leu Val 
1               5                   10                  15      

Pro Lys Lys Pro Leu Pro Ser Pro Asp Gln Pro Glu Glu Ser Ser Asp 
            20                  25                  30          

Ser Tyr Phe Arg Ser 
        35          

<210>   4905
<211>   105
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4905
atgttttctc ttgtccttat tttaaccatt caagaaattt cgagaaccct ctacaatttc   60
cagtcaaata aattgcattc gttttctcaa gcaggtatac tagtg                   105

<210>   4906
<211>   35
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein

<400>   4906
Met Phe Ser Leu Val Leu Ile Leu Thr Ile Gln Glu Ile Ser Arg Thr 
1               5                   10                  15      

Leu Tyr Asn Phe Gln Ser Asn Lys Leu His Ser Phe Ser Gln Ala Gly 
            20                  25                  30          

Ile Leu Val 
        35  

<210>   4907
<211>   984
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4907
atggcaaaag atattcgtgt cttactttac tacctttata ctccaattga aaatgcagag   60
caatttgctg cagaccactt ggctttctgt aaatcaatcg gccttaaagg ccgtatccta   120
gtcgctgacg agggaattaa cggaacagtt tcaggtgact atgaaacaac tcaaaaatac   180
atggactacg ttcacagcct tccaggaatg gaagaactct ggttcaagat tgacgaagaa   240
aatgaacaag ccttcaagaa gatgtttgtt cgctacaaga aagaaattgt ccaccttggt   300
ttggaagaca acgactttga caatgacatc aacccacttg aaacaacagg tgcttacttg   360
tctccaaaag agttcaaaga agcgcttctt gataaagata ccgttgtcct tgacacacgt   420
aacgattatg agtacgacct aggacatttc cgtggagcta ttcgcccaga tattcgcaac   480
ttccgtgagt taccacaatg ggtccgtgat aacaaggaaa aattcatgga caagcgtgtc   540
gtggtttact gtacaggtgg cgttcgctgt gagaaattct caggctggat ggtccgtgaa   600
ggctacaaag atgtcggcca attgcacgga ggaatcgcaa cttacggtaa agacccagaa   660
gttcaaggtg agctttggga tgggaaaatg tacgtctttg acgagcgtat tgccgttgat   720
gtcaaccatg tcaacccaac tatcgtaggg aaagactggt ttgatggaac accatgtgaa   780
cgttatgtca actgtggaaa tccattctgt aaccgtcgta tcttgacatc agaagaaaat   840
gaagacaagt accttcgtgg atgctcacac gagtgccgtg ttcacccacg taaccgctat   900
gtttcaaaaa atgaattgac acaagctgaa gttatcgagc gcctagccgc tatcggtgaa   960
agcttggatc aagcagctac tgta                                          984

<210>   4908
<211>   328
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902128 (0.E+01)

<400>   4908
Met Ala Lys Asp Ile Arg Val Leu Leu Tyr Tyr Leu Tyr Thr Pro Ile 
1               5                   10                  15      

Glu Asn Ala Glu Gln Phe Ala Ala Asp His Leu Ala Phe Cys Lys Ser 
            20                  25                  30          

Ile Gly Leu Lys Gly Arg Ile Leu Val Ala Asp Glu Gly Ile Asn Gly 
        35                  40                  45              

Thr Val Ser Gly Asp Tyr Glu Thr Thr Gln Lys Tyr Met Asp Tyr Val 
    50                  55                  60                  

His Ser Leu Pro Gly Met Glu Glu Leu Trp Phe Lys Ile Asp Glu Glu 
65                  70                  75                  80  

Asn Glu Gln Ala Phe Lys Lys Met Phe Val Arg Tyr Lys Lys Glu Ile 
                85                  90                  95      

Val His Leu Gly Leu Glu Asp Asn Asp Phe Asp Asn Asp Ile Asn Pro 
            100                 105                 110         

Leu Glu Thr Thr Gly Ala Tyr Leu Ser Pro Lys Glu Phe Lys Glu Ala 
        115                 120                 125             

Leu Leu Asp Lys Asp Thr Val Val Leu Asp Thr Arg Asn Asp Tyr Glu 
    130                 135                 140                 

Tyr Asp Leu Gly His Phe Arg Gly Ala Ile Arg Pro Asp Ile Arg Asn 
145                 150                 155                 160 

Phe Arg Glu Leu Pro Gln Trp Val Arg Asp Asn Lys Glu Lys Phe Met 
                165                 170                 175     

Asp Lys Arg Val Val Val Tyr Cys Thr Gly Gly Val Arg Cys Glu Lys 
            180                 185                 190         

Phe Ser Gly Trp Met Val Arg Glu Gly Tyr Lys Asp Val Gly Gln Leu 
        195                 200                 205             

His Gly Gly Ile Ala Thr Tyr Gly Lys Asp Pro Glu Val Gln Gly Glu 
    210                 215                 220                 

Leu Trp Asp Gly Lys Met Tyr Val Phe Asp Glu Arg Ile Ala Val Asp 
225                 230                 235                 240 

Val Asn His Val Asn Pro Thr Ile Val Gly Lys Asp Trp Phe Asp Gly 
                245                 250                 255     

Thr Pro Cys Glu Arg Tyr Val Asn Cys Gly Asn Pro Phe Cys Asn Arg 
            260                 265                 270         

Arg Ile Leu Thr Ser Glu Glu Asn Glu Asp Lys Tyr Leu Arg Gly Cys 
        275                 280                 285             

Ser His Glu Cys Arg Val His Pro Arg Asn Arg Tyr Val Ser Lys Asn 
    290                 295                 300                 

Glu Leu Thr Gln Ala Glu Val Ile Glu Arg Leu Ala Ala Ile Gly Glu 
305                 310                 315                 320 

Ser Leu Asp Gln Ala Ala Thr Val 
                325             

<210>   4909
<211>   951
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4909
ttgaagagat tttcgaagag tataaagttt gtttttgtat ctttcagaaa aataaggtat   60
actgtatgta aacgatttca aaggagtcca gttatggcga aaacattttt tattccaaat   120
aaacagagca ttttaggaga acaagagatt ttgaatgcca agtcgatctt ggccttgcta   180
gacggtttgg agtcacatag ctatgatgta gtctatctcc gtcagcctct taatcgtctc   240
gaatatatcg agtgtgcgat agtggggcaa tcacaatttc tctttaaggt cagttatgct   300
gatggtcaaa aggcttaccg tgtcgatctt cctgacctac taacaaagac agactggcag   360
attatcaagt catttttaga tgctttgctt gcttatacag ggactgatat tgaagggcta   420
gatggttttg attttgaagc ttatttccaa gcaagtattc aagcctatct agcagaccct   480
gtagctcgtt ttacgatttg ccaaggaatt tttaatccta ttttctttag tcgtgagaac   540
ttgaaaagct ttttagaggc agatggcttg gctcagtttg aagcgcgtgt gcgtgcggtt   600
caagagacag atgcctactt tgcgagagtt tccttctatc aggatggaga aggaaaagtg   660
catggcgttt accatctagc tcaaggagtc aagacagttt taccgagaga accgtttgtt   720
cctgcagcct atattgagca attggtggat aaggaagtcc agtgggagat tgacttggtt   780
caaatcacag gagatggctc taaaccagaa gactatgaag ccattgctcg cttggactat   840
gcaaaattct tagaggtatt acccccatct ttttaccacc aactagacgc caatcaaata   900
gaagtgcaac ccatattaga caaagatttt aaaacattag cacaagaaaa g            951

<210>   4910
<211>   317
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902129 (e-163)

<400>   4910
Met Lys Arg Phe Ser Lys Ser Ile Lys Phe Val Phe Val Ser Phe Arg 
1               5                   10                  15      

Lys Ile Arg Tyr Thr Val Cys Lys Arg Phe Gln Arg Ser Pro Val Met 
            20                  25                  30          

Ala Lys Thr Phe Phe Ile Pro Asn Lys Gln Ser Ile Leu Gly Glu Gln 
        35                  40                  45              

Glu Ile Leu Asn Ala Lys Ser Ile Leu Ala Leu Leu Asp Gly Leu Glu 
    50                  55                  60                  

Ser His Ser Tyr Asp Val Val Tyr Leu Arg Gln Pro Leu Asn Arg Leu 
65                  70                  75                  80  

Glu Tyr Ile Glu Cys Ala Ile Val Gly Gln Ser Gln Phe Leu Phe Lys 
                85                  90                  95      

Val Ser Tyr Ala Asp Gly Gln Lys Ala Tyr Arg Val Asp Leu Pro Asp 
            100                 105                 110         

Leu Leu Thr Lys Thr Asp Trp Gln Ile Ile Lys Ser Phe Leu Asp Ala 
        115                 120                 125             

Leu Leu Ala Tyr Thr Gly Thr Asp Ile Glu Gly Leu Asp Gly Phe Asp 
    130                 135                 140                 

Phe Glu Ala Tyr Phe Gln Ala Ser Ile Gln Ala Tyr Leu Ala Asp Pro 
145                 150                 155                 160 

Val Ala Arg Phe Thr Ile Cys Gln Gly Ile Phe Asn Pro Ile Phe Phe 
                165                 170                 175     

Ser Arg Glu Asn Leu Lys Ser Phe Leu Glu Ala Asp Gly Leu Ala Gln 
            180                 185                 190         

Phe Glu Ala Arg Val Arg Ala Val Gln Glu Thr Asp Ala Tyr Phe Ala 
        195                 200                 205             

Arg Val Ser Phe Tyr Gln Asp Gly Glu Gly Lys Val His Gly Val Tyr 
    210                 215                 220                 

His Leu Ala Gln Gly Val Lys Thr Val Leu Pro Arg Glu Pro Phe Val 
225                 230                 235                 240 

Pro Ala Ala Tyr Ile Glu Gln Leu Val Asp Lys Glu Val Gln Trp Glu 
                245                 250                 255     

Ile Asp Leu Val Gln Ile Thr Gly Asp Gly Ser Lys Pro Glu Asp Tyr 
            260                 265                 270         

Glu Ala Ile Ala Arg Leu Asp Tyr Ala Lys Phe Leu Glu Val Leu Pro 
        275                 280                 285             

Pro Ser Phe Tyr His Gln Leu Asp Ala Asn Gln Ile Glu Val Gln Pro 
    290                 295                 300                 

Ile Leu Asp Lys Asp Phe Lys Thr Leu Ala Gln Glu Lys 
305                 310                 315         

<210>   4911
<211>   1062
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4911
atgaaacaag aatggtttga aagtaatgat tttgtaaaaa caacaagcaa gaacaagcct   60
gaagagcaag ctcaagaggt tgcagacaag gctgaagaaa cgatagccga tctcgataca   120
ccaattgaaa aaaatactca gttagaggag gaagtccctc aagctgaagt cgaattggaa   180
agccagcaag aagagaaaat tgaagctcct gaagacagtg aagcgagaac agaaatagaa   240
gaaaagaagg catctaattc tactgaagaa gagccagacc tttctaaaga aacagaaaaa   300
gtcactatag ctgaagagag ccaagaagct cttcctcagc aaaaagcaac cacgaaagag   360
ccacttctta tcagtaaatc tttagaaagt ccttatatcc ccgaccaagc tccaaaatct   420
agggataaat ggaaagagca agtgcttgat ttttggtctt ggctagtgga agcgatcaaa   480
tctcctacaa gtaagttgga aacaagtatc acacacagtt acacagcctt tctcttgctc   540
attctgtttt ctgcatcttc ctttttcttt agtatctatc acatcaaaca tgcttactat   600
ggacatatag caagcattaa cagtcgcttc cctgagcagc tagctccttt aactcttttt   660
tctatcatct ctatcctagt agcgacaaca ctcttcttct tttcattcct cttgggtagt   720
ttcgttgtga gacgatttat ccaccaggaa aaggactgga cgctagacaa ggttctccaa   780
caatatagtc aactcttggc aattccaatc ttcctcactg ctattgctag tttctttgct   840
ttctttgata gcctacgatt tacagccctc ttgtgtgtga ttagcattgg aatcattctg   900
cttgccagtc tccatatcat tacaagacca agtcaagcaa gtgaaaccga ctccttctat   960
caattattct tgtctgtcct tgtgaacgga gttattatcc tcctcttctt tgtagctgaa   1020
gtggcactga ttggagatta tcttcgtatc ttggcctttc tt                      1062

<210>   4912
<211>   354
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902130 (0.E+01)

<400>   4912
Met Lys Gln Glu Trp Phe Glu Ser Asn Asp Phe Val Lys Thr Thr Ser 
1               5                   10                  15      

Lys Asn Lys Pro Glu Glu Gln Ala Gln Glu Val Ala Asp Lys Ala Glu 
            20                  25                  30          

Glu Thr Ile Ala Asp Leu Asp Thr Pro Ile Glu Lys Asn Thr Gln Leu 
        35                  40                  45              

Glu Glu Glu Val Pro Gln Ala Glu Val Glu Leu Glu Ser Gln Gln Glu 
    50                  55                  60                  

Glu Lys Ile Glu Ala Pro Glu Asp Ser Glu Ala Arg Thr Glu Ile Glu 
65                  70                  75                  80  

Glu Lys Lys Ala Ser Asn Ser Thr Glu Glu Glu Pro Asp Leu Ser Lys 
                85                  90                  95      

Glu Thr Glu Lys Val Thr Ile Ala Glu Glu Ser Gln Glu Ala Leu Pro 
            100                 105                 110         

Gln Gln Lys Ala Thr Thr Lys Glu Pro Leu Leu Ile Ser Lys Ser Leu 
        115                 120                 125             

Glu Ser Pro Tyr Ile Pro Asp Gln Ala Pro Lys Ser Arg Asp Lys Trp 
    130                 135                 140                 

Lys Glu Gln Val Leu Asp Phe Trp Ser Trp Leu Val Glu Ala Ile Lys 
145                 150                 155                 160 

Ser Pro Thr Ser Lys Leu Glu Thr Ser Ile Thr His Ser Tyr Thr Ala 
                165                 170                 175     

Phe Leu Leu Leu Ile Leu Phe Ser Ala Ser Ser Phe Phe Phe Ser Ile 
            180                 185                 190         

Tyr His Ile Lys His Ala Tyr Tyr Gly His Ile Ala Ser Ile Asn Ser 
        195                 200                 205             

Arg Phe Pro Glu Gln Leu Ala Pro Leu Thr Leu Phe Ser Ile Ile Ser 
    210                 215                 220                 

Ile Leu Val Ala Thr Thr Leu Phe Phe Phe Ser Phe Leu Leu Gly Ser 
225                 230                 235                 240 

Phe Val Val Arg Arg Phe Ile His Gln Glu Lys Asp Trp Thr Leu Asp 
                245                 250                 255     

Lys Val Leu Gln Gln Tyr Ser Gln Leu Leu Ala Ile Pro Ile Phe Leu 
            260                 265                 270         

Thr Ala Ile Ala Ser Phe Phe Ala Phe Phe Asp Ser Leu Arg Phe Thr 
        275                 280                 285             

Ala Leu Leu Cys Val Ile Ser Ile Gly Ile Ile Leu Leu Ala Ser Leu 
    290                 295                 300                 

His Ile Ile Thr Arg Pro Ser Gln Ala Ser Glu Thr Asp Ser Phe Tyr 
305                 310                 315                 320 

Gln Leu Phe Leu Ser Val Leu Val Asn Gly Val Ile Ile Leu Leu Phe 
                325                 330                 335     

Phe Val Ala Glu Val Ala Leu Ile Gly Asp Tyr Leu Arg Ile Leu Ala 
            340                 345                 350         

Phe Leu 
        

<210>   4913
<211>   909
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4913
atgcgtaaat ggacaaaagg atttctcatc tttggtgtgg tgactaccgt tatcggcttt   60
atcctgcttt ttgtaggtat ccaatctgac gggattaaga gcctactttc catgtccaaa   120
gaacctgtct atgatagccg tacggaaaag ctaacctttg gcaaggaagt cgaaaaccta   180
gaaattactc tccaccaaca cacgctcacc atcacagact ctttcgatga tcaaatccac   240
atttcttacc atccatctct ttctgctcac catgatctta tcaccaatca gaacgataga   300
actctgagtc tcactgataa gaaactgtct gaaactccgt ttctctcttc tggaattggt   360
gggattcttc atatcgcaag tagctactct agtcgttttg aagaagttat tctccgacta   420
ccaaaaggga gaactctaaa agggatcaac atctcagcca atcgcggaca aaccaccatc   480
ataaatgcta gccttgaaaa tgcgaccctc aatacaaaca gctatatcct ccgaattgaa   540
ggaagtcgta tcaaaaacag taaactcaca acgcccaata tcgttaatat ctttgataca   600
gttcttacag atagtcagct agagtcaaca gagaatcact tccacgctga aaatatccaa   660
gtccatggca aggttgaact gactgccaaa gattatctca gaatcatcct agaccagaaa   720
gaaagccaac gaattaactg ggacatctca agcaactatg gttctatctt ccaattcaca   780
agagaaaagc ctgaatcaag aggtacggaa ttaagcaacc cttacaaaac tgaaaaaacc   840
gatgtcaagg atcaactcat tgcgagatct gatgataata ttgatctaat atccacacca   900
agcagacgt                                                           909

<210>   4914
<211>   303
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: outside
<223>   Similar to strain R6 sequence 15902131 (e-172)

<400>   4914
Met Arg Lys Trp Thr Lys Gly Phe Leu Ile Phe Gly Val Val Thr Thr 
1               5                   10                  15      

Val Ile Gly Phe Ile Leu Leu Phe Val Gly Ile Gln Ser Asp Gly Ile 
            20                  25                  30          

Lys Ser Leu Leu Ser Met Ser Lys Glu Pro Val Tyr Asp Ser Arg Thr 
        35                  40                  45              

Glu Lys Leu Thr Phe Gly Lys Glu Val Glu Asn Leu Glu Ile Thr Leu 
    50                  55                  60                  

His Gln His Thr Leu Thr Ile Thr Asp Ser Phe Asp Asp Gln Ile His 
65                  70                  75                  80  

Ile Ser Tyr His Pro Ser Leu Ser Ala His His Asp Leu Ile Thr Asn 
                85                  90                  95      

Gln Asn Asp Arg Thr Leu Ser Leu Thr Asp Lys Lys Leu Ser Glu Thr 
            100                 105                 110         

Pro Phe Leu Ser Ser Gly Ile Gly Gly Ile Leu His Ile Ala Ser Ser 
        115                 120                 125             

Tyr Ser Ser Arg Phe Glu Glu Val Ile Leu Arg Leu Pro Lys Gly Arg 
    130                 135                 140                 

Thr Leu Lys Gly Ile Asn Ile Ser Ala Asn Arg Gly Gln Thr Thr Ile 
145                 150                 155                 160 

Ile Asn Ala Ser Leu Glu Asn Ala Thr Leu Asn Thr Asn Ser Tyr Ile 
                165                 170                 175     

Leu Arg Ile Glu Gly Ser Arg Ile Lys Asn Ser Lys Leu Thr Thr Pro 
            180                 185                 190         

Asn Ile Val Asn Ile Phe Asp Thr Val Leu Thr Asp Ser Gln Leu Glu 
        195                 200                 205             

Ser Thr Glu Asn His Phe His Ala Glu Asn Ile Gln Val His Gly Lys 
    210                 215                 220                 

Val Glu Leu Thr Ala Lys Asp Tyr Leu Arg Ile Ile Leu Asp Gln Lys 
225                 230                 235                 240 

Glu Ser Gln Arg Ile Asn Trp Asp Ile Ser Ser Asn Tyr Gly Ser Ile 
                245                 250                 255     

Phe Gln Phe Thr Arg Glu Lys Pro Glu Ser Arg Gly Thr Glu Leu Ser 
            260                 265                 270         

Asn Pro Tyr Lys Thr Glu Lys Thr Asp Val Lys Asp Gln Leu Ile Ala 
        275                 280                 285             


Arg Ser Asp Asp Asn Ile Asp Leu Ile Ser Thr Pro Ser Arg Arg 
    290                 295                 300             

<210>   4915
<211>   591
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4915
atgacaagaa ctgaatacct gactcagcta gaactctatc tcaagaaact acctgaagct   60
gaccgtatcg aagccatgga ctatttcaga gagctctttg acgatgctgg agtcgaagga   120
gaagaagaac tcatcgctag tttgggaact cccaaagaag cggcccacga agttctatcc   180
aatcttctcg ataaaaaaat caatgaagca cccgctcaaa aaaataaccg acaaatttta   240
catatcgcct tgttagccct ccttgcagca cctatcggca ttcctctggg aatcgccatc   300
ctcgtgaccc tgttcgcaat tcttgtagcc gctttgactg tcattctggc tttctttgca   360
gtttccatac tgggtatcat cggcggattc ctatttttag ttgaaagttt cactgtcctc   420
gcccaagcca aatcagcctt tatcttgatt tttggttctg gtttactggc tatcggtgct   480
tcttcgctag ttttacttgg catttcctat gcaactcgct tcttcggtct actcattgtt   540
cgtctggtac aatttgttct taaaaaagga aagagaggta atcagcatgc g            591

<210>   4916
<211>   197
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902132 (e-103)

<400>   4916
Met Thr Arg Thr Glu Tyr Leu Thr Gln Leu Glu Leu Tyr Leu Lys Lys 
1               5                   10                  15      

Leu Pro Glu Ala Asp Arg Ile Glu Ala Met Asp Tyr Phe Arg Glu Leu 
            20                  25                  30          

Phe Asp Asp Ala Gly Val Glu Gly Glu Glu Glu Leu Ile Ala Ser Leu 
        35                  40                  45              

Gly Thr Pro Lys Glu Ala Ala His Glu Val Leu Ser Asn Leu Leu Asp 
    50                  55                  60                  

Lys Lys Ile Asn Glu Ala Pro Ala Gln Lys Asn Asn Arg Gln Ile Leu 
65                  70                  75                  80  

His Ile Ala Leu Leu Ala Leu Leu Ala Ala Pro Ile Gly Ile Pro Leu 
                85                  90                  95      

Gly Ile Ala Ile Leu Val Thr Leu Phe Ala Ile Leu Val Ala Ala Leu 
            100                 105                 110         

Thr Val Ile Leu Ala Phe Phe Ala Val Ser Ile Leu Gly Ile Ile Gly 
        115                 120                 125             

Gly Phe Leu Phe Leu Val Glu Ser Phe Thr Val Leu Ala Gln Ala Lys 
    130                 135                 140                 

Ser Ala Phe Ile Leu Ile Phe Gly Ser Gly Leu Leu Ala Ile Gly Ala 
145                 150                 155                 160 

Ser Ser Leu Val Leu Leu Gly Ile Ser Tyr Ala Thr Arg Phe Phe Gly 
                165                 170                 175     

Leu Leu Ile Val Arg Leu Val Gln Phe Val Leu Lys Lys Gly Lys Arg 
            180                 185                 190         

Gly Asn Gln His Ala 
        195         

<210>   4917
<211>   324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4917
atgtactttc caacatcctc tgccttgatt gaatttctca tcttggctgt actggagcag   60
ggtgattctt atggttatga gattagccaa accattaagc tgatcgctaa tatcaaagaa   120
tccacactct atcccattct caaaaaattg gaaggcaata gctttctgac aacctattct   180
agagagttcc aaggtcgcat gcgcaaatac tactccttga caaacggtgg tatagagcag   240
ctcttgaccc taaaagatga atgggcactc tatacagaca ccatcaatgg catcatagaa   300
gggagtatcc gccatgacaa gaac                                          324

<210>   4918
<211>   108
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902133 (7.E-58)

<400>   4918
Met Tyr Phe Pro Thr Ser Ser Ala Leu Ile Glu Phe Leu Ile Leu Ala 
1               5                   10                  15      

Val Leu Glu Gln Gly Asp Ser Tyr Gly Tyr Glu Ile Ser Gln Thr Ile 
            20                  25                  30          

Lys Leu Ile Ala Asn Ile Lys Glu Ser Thr Leu Tyr Pro Ile Leu Lys 
        35                  40                  45              

Lys Leu Glu Gly Asn Ser Phe Leu Thr Thr Tyr Ser Arg Glu Phe Gln 
    50                  55                  60                  

Gly Arg Met Arg Lys Tyr Tyr Ser Leu Thr Asn Gly Gly Ile Glu Gln 
65                  70                  75                  80  

Leu Leu Thr Leu Lys Asp Glu Trp Ala Leu Tyr Thr Asp Thr Ile Asn 
                85                  90                  95      

Gly Ile Ile Glu Gly Ser Ile Arg His Asp Lys Asn 
            100                 105             

<210>   4919
<211>   1164
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4919
atgaaaaagc aatcactctt ttttgttcca ggtattatcc tgattggtgt ttccttgcga   60
actcctttta ctgttttacc cattattttg ggaaatattt cgcaaggtct ggaggtagaa   120
gttagttcgc ttggtgtctt gaccagcctg cctctcctta tgtttaccct cttttcacca   180
ttttctaccc aactggctca gaaaatcggc ttggagcatc tcttcaccta cagcctcttc   240
ttcttgacca tcggctcact tattcgacta atcaatctgc ccctgctcta tctaggaacc   300
ttgatggttg gggcaagtgt cgcagtcatc aatgtcctgc ttcctagtct tatccaagcc   360
aatcaaccaa agaaaattgg ttttctgacc accttatatg taacgtctat ggggattgca   420
acggctctgg cttcctatct agctgtgccc attacacaag ccagttcttg gaaaggactt   480
atccttctcc tcacgttact ctgtctagca acttttttgg tctggctccc aaatcaccgc   540
tataatcata gactagctcc acaaaccaaa caaaaaagtc aaataaaggt catgcgtaat   600
aaacaggttt gggcaattat tatcttttca ggttttcaat ccttgatctt ttacaccgtc   660
atgacctggt tacctaccat gtctatccat gcaggtctat ccagtcacga agctggcttg   720
ctgacttcta tcttatctct gattagcatt cctttttcaa tgaccatccc aagcctgaca   780
accagtttat ctactcgcaa ccgtcagctc atgctcactc tggtttcact agctggtgtg   840
gtcggcattt ccatgctctt tttcccaatc aataatttca tttactggct tgccatccat   900
ctcctcatcg gaaccgcaac cagtgccctc ttcccttatc tcatggtcaa cttttcactc   960
aagacaagcg cccctgaaaa gacagcccaa ttgtccggcc tatctcaaac aggaggctat   1020
atcctagcag cctttgggcc aaccctcttt ggttacagtt ttgacctgtt ccactcttgg   1080
gtaccatctg tagctgccct cttgctcatc gatatcctga tgactgtggc cctctttaca   1140
gtggacagag cggataagat cctt                                          1164

<210>   4920
<211>   388
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902134 (0.E+01)

<400>   4920
Met Lys Lys Gln Ser Leu Phe Phe Val Pro Gly Ile Ile Leu Ile Gly 
1               5                   10                  15      

Val Ser Leu Arg Thr Pro Phe Thr Val Leu Pro Ile Ile Leu Gly Asn 
            20                  25                  30          

Ile Ser Gln Gly Leu Glu Val Glu Val Ser Ser Leu Gly Val Leu Thr 
        35                  40                  45              

Ser Leu Pro Leu Leu Met Phe Thr Leu Phe Ser Pro Phe Ser Thr Gln 
    50                  55                  60                  

Leu Ala Gln Lys Ile Gly Leu Glu His Leu Phe Thr Tyr Ser Leu Phe 
65                  70                  75                  80  

Phe Leu Thr Ile Gly Ser Leu Ile Arg Leu Ile Asn Leu Pro Leu Leu 
                85                  90                  95      

Tyr Leu Gly Thr Leu Met Val Gly Ala Ser Val Ala Val Ile Asn Val 
            100                 105                 110         

Leu Leu Pro Ser Leu Ile Gln Ala Asn Gln Pro Lys Lys Ile Gly Phe 
        115                 120                 125             

Leu Thr Thr Leu Tyr Val Thr Ser Met Gly Ile Ala Thr Ala Leu Ala 
    130                 135                 140                 

Ser Tyr Leu Ala Val Pro Ile Thr Gln Ala Ser Ser Trp Lys Gly Leu 
145                 150                 155                 160 

Ile Leu Leu Leu Thr Leu Leu Cys Leu Ala Thr Phe Leu Val Trp Leu 
                165                 170                 175     

Pro Asn His Arg Tyr Asn His Arg Leu Ala Pro Gln Thr Lys Gln Lys 
            180                 185                 190         

Ser Gln Ile Lys Val Met Arg Asn Lys Gln Val Trp Ala Ile Ile Ile 
        195                 200                 205             

Phe Ser Gly Phe Gln Ser Leu Ile Phe Tyr Thr Val Met Thr Trp Leu 
    210                 215                 220                 

Pro Thr Met Ser Ile His Ala Gly Leu Ser Ser His Glu Ala Gly Leu 
225                 230                 235                 240 

Leu Thr Ser Ile Leu Ser Leu Ile Ser Ile Pro Phe Ser Met Thr Ile 
                245                 250                 255     

Pro Ser Leu Thr Thr Ser Leu Ser Thr Arg Asn Arg Gln Leu Met Leu 
            260                 265                 270         

Thr Leu Val Ser Leu Ala Gly Val Val Gly Ile Ser Met Leu Phe Phe 
        275                 280                 285             

Pro Ile Asn Asn Phe Ile Tyr Trp Leu Ala Ile His Leu Leu Ile Gly 
    290                 295                 300                 

Thr Ala Thr Ser Ala Leu Phe Pro Tyr Leu Met Val Asn Phe Ser Leu 
305                 310                 315                 320 

Lys Thr Ser Ala Pro Glu Lys Thr Ala Gln Leu Ser Gly Leu Ser Gln 
                325                 330                 335     

Thr Gly Gly Tyr Ile Leu Ala Ala Phe Gly Pro Thr Leu Phe Gly Tyr 
            340                 345                 350         

Ser Phe Asp Leu Phe His Ser Trp Val Pro Ser Val Ala Ala Leu Leu 
        355                 360                 365             

Leu Ile Asp Ile Leu Met Thr Val Ala Leu Phe Thr Val Asp Arg Ala 
    370                 375                 380                 

Asp Lys Ile Leu 
385             

<210>   4921
<211>   1062
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4921
gtgactcaaa atgttgaaag tcttctcgta tccattgtaa tcagtgcata caatgaagaa   60
aaatatctgc ctggtctaat tgaagactta aaaaatcaaa cctatcctaa agaggatatt   120
gaaattctat ttataaatgc tatgtccaca gatgggacca cagctatcat tcagcaattt   180
ataaaggaag atacagagtt taactcaatt agattgtata acaatcctaa gaaaaatcaa   240
gctagtggtt ttaacctggg agttaaacat tctgtagggg accttatttt aaaaattgat   300
gctcattcaa aagttactga gacttttgta atgaacaatg tggctattat tcaacaaggt   360
gaatttgtct gtggggggcc tagaccgacg attgtcgaag gaaaaggaaa atgggcagag   420
accttgcatc ttgttgagga aaatatgttt ggcagtagca ttgccaatta tcgaaatagt   480
tctgaggata gatatgtttc ttctattttt catggaatgt ataaacgaga ggttttccag   540
aaggttggtt tagtaaatga gcaacttggc cgaactgaag ataatgatat tcattataga   600
attcgagaat atggttataa aatccgctat agcccaagta ttctatctta tcagtatatt   660
cgaccaacat tcaagaaaat gctgcatcaa aagtattcaa atggtttgtg gattggcttg   720
acaagtcatg ttcagtttaa gtgtttatca ttatttcact atgttccttg tttatttgtt   780
ttgagtcttg tgtttagtct agcattgtta ccgatcacat tcgtattcat aactttacta   840
ttaggtgcct attttctact tttgtcatta ctcactttgc tgactttatt aaaacataaa   900
aatggatttc taattgtgat gccctttatt ttattttcca ttcactttgc ttatggcctt   960
gggacgattg taggtttaat tagaggattt aaatggaaga aggagtacaa gagaacaata   1020
atttatttgg ataaaataag ccaaataaat caaaatatgc ta                      1062

<210>   4922
<211>   354
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   glycosyl transferase
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902135 (0.E+01)

<400>   4922
Met Thr Gln Asn Val Glu Ser Leu Leu Val Ser Ile Val Ile Ser Ala 
1               5                   10                  15      

Tyr Asn Glu Glu Lys Tyr Leu Pro Gly Leu Ile Glu Asp Leu Lys Asn 
            20                  25                  30          

Gln Thr Tyr Pro Lys Glu Asp Ile Glu Ile Leu Phe Ile Asn Ala Met 
        35                  40                  45              

Ser Thr Asp Gly Thr Thr Ala Ile Ile Gln Gln Phe Ile Lys Glu Asp 
    50                  55                  60                  

Thr Glu Phe Asn Ser Ile Arg Leu Tyr Asn Asn Pro Lys Lys Asn Gln 
65                  70                  75                  80  

Ala Ser Gly Phe Asn Leu Gly Val Lys His Ser Val Gly Asp Leu Ile 
                85                  90                  95      

Leu Lys Ile Asp Ala His Ser Lys Val Thr Glu Thr Phe Val Met Asn 
            100                 105                 110         

Asn Val Ala Ile Ile Gln Gln Gly Glu Phe Val Cys Gly Gly Pro Arg 
        115                 120                 125             

Pro Thr Ile Val Glu Gly Lys Gly Lys Trp Ala Glu Thr Leu His Leu 
    130                 135                 140                 

Val Glu Glu Asn Met Phe Gly Ser Ser Ile Ala Asn Tyr Arg Asn Ser 
145                 150                 155                 160 

Ser Glu Asp Arg Tyr Val Ser Ser Ile Phe His Gly Met Tyr Lys Arg 
                165                 170                 175     

Glu Val Phe Gln Lys Val Gly Leu Val Asn Glu Gln Leu Gly Arg Thr 
            180                 185                 190         

Glu Asp Asn Asp Ile His Tyr Arg Ile Arg Glu Tyr Gly Tyr Lys Ile 
        195                 200                 205             

Arg Tyr Ser Pro Ser Ile Leu Ser Tyr Gln Tyr Ile Arg Pro Thr Phe 
    210                 215                 220                 

Lys Lys Met Leu His Gln Lys Tyr Ser Asn Gly Leu Trp Ile Gly Leu 
225                 230                 235                 240 


Thr Ser His Val Gln Phe Lys Cys Leu Ser Leu Phe His Tyr Val Pro 
                245                 250                 255     

Cys Leu Phe Val Leu Ser Leu Val Phe Ser Leu Ala Leu Leu Pro Ile 
            260                 265                 270         

Thr Phe Val Phe Ile Thr Leu Leu Leu Gly Ala Tyr Phe Leu Leu Leu 
        275                 280                 285             

Ser Leu Leu Thr Leu Leu Thr Leu Leu Lys His Lys Asn Gly Phe Leu 
    290                 295                 300                 

Ile Val Met Pro Phe Ile Leu Phe Ser Ile His Phe Ala Tyr Gly Leu 
305                 310                 315                 320 

Gly Thr Ile Val Gly Leu Ile Arg Gly Phe Lys Trp Lys Lys Glu Tyr 
                325                 330                 335     

Lys Arg Thr Ile Ile Tyr Leu Asp Lys Ile Ser Gln Ile Asn Gln Asn 
            340                 345                 350         

Met Leu 
        

<210>   4923
<211>   1848
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4923
atgaataaaa aactaacaga ttatgtgatt gatctggtgg aaattttaaa taaacaacaa   60
aagcaggttt tctggggaat atttgatatt ttcagtatgg tggtttccat cattgtatct   120
tatattttat tttatgggct gattaatcca gcacctgttg actacattat ctatacgagt   180
ttggccttcc tgttctatca attgatgatt ggtttttggg ggttgaacgc gagcattagt   240
cgttacagca agattacgga tttcatgaaa atcttttttg gtgtgactgc tagcagtgtc   300
ttgtcatata gtatctgtta tgccttcttg ccactcttct ccatccgttt catcattctc   360
tttatcttgt tgagtacctt cttgatttta ttgccacgga ttacttggca gttaatctac   420
tccagacgca aaaaaggtag tggtgatgga gaacaccgtc ggaccttctt gattggtgcc   480
ggtgatggtg gggctctttt tatggatagt taccaacatc caaccagtga attagaactg   540
gtcggtattt tggataagga ttctaagaaa aagggtcaaa aacttggtgg tattcctgtt   600
ttgggctctt atgacaatct gcctgaatta gccaaacgcc atcaaatcga gcgtgtcatc   660
gttgcgattc cgtcgctgga tccgtcagaa tatgagcgta tcttgcagat gtgtaataag   720
ctgggtgtca aatgttacaa gatgcctaag gttgaaactg ttgttcaggg ccttcaccaa   780
gcaggtactg gcttccaaaa aattgatatt acggaccttt tgggtcgtca ggaaatccgt   840
cttgacgaat cgcgtctggg tgcagaactg acaggtaaga ccatcttagt cacaggagct   900
ggaggttcaa tcggttctga aatctgtcgt caagttagtc gcttcaatcc tgaacgcatt   960
gtcttgctcg gtcatgggga aaactcaatc taccttgttt atcatgaatt gattcgtaag   1020
ttccaaggga ttgattatgt acctgtgatt gcggacattc aagactatga tcgtttgttg   1080
caagtctttg agcagtacaa acctgctatt gtttatcatg cggcagccca caagcatgtt   1140
cctatgatgg agcgcaatcc aaaagaagcc ttcaaaaaca atatccgtgg aacttacaat   1200
gttgctaagg ctgttgatga agctaaagtg tctaagatgg ttatgatttc gacagataag   1260
gcagtcaatc caccaaatgt tatgggagca accaagcgcg tggcggagtt gattgtcact   1320
ggctttaacc aacgtagcca atcaacctac tgtgcagttc gttttgggaa tgttcttggt   1380
agccgtggta gtgtcattcc agtctttgaa cgtcagattg ctgaaggtgg gcctgtaacg   1440
gtgacagact tccgtatgac ccgttacttt atgaccattc cagaagctag ccgtctggtt   1500
atccatgctg gtgcttatgc caaagatggg gaagtcttta tccttgatat gggcaaacca   1560
gtcaagattt atgacttggc caagaagatg gtgcttctaa gtggccacac tgaaagtgaa   1620
attccaatcg ttgaagttgg aatccgccca ggtgaaaaac tctacgaaga actcttggta   1680
tcaaccgaac tcgttgataa tcaagttatg gataagattt tcgttggtaa ggttaatgtc   1740
atgcctttag aatccatcaa tcaaaagatt ggagagttcc gcactctcag tggagatgag   1800
ttgaagcaag ctattatcgc ctttgctaat caaacaaccc acattgaa                1848

<210>   4924
<211>   616
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   capsular polysaccharide biosynthesis protein, putative
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902136 (0.E+01)

<400>   4924
Met Asn Lys Lys Leu Thr Asp Tyr Val Ile Asp Leu Val Glu Ile Leu 
1               5                   10                  15      

Asn Lys Gln Gln Lys Gln Val Phe Trp Gly Ile Phe Asp Ile Phe Ser 
            20                  25                  30          

Met Val Val Ser Ile Ile Val Ser Tyr Ile Leu Phe Tyr Gly Leu Ile 
        35                  40                  45              

Asn Pro Ala Pro Val Asp Tyr Ile Ile Tyr Thr Ser Leu Ala Phe Leu 
    50                  55                  60                  

Phe Tyr Gln Leu Met Ile Gly Phe Trp Gly Leu Asn Ala Ser Ile Ser 
65                  70                  75                  80  

Arg Tyr Ser Lys Ile Thr Asp Phe Met Lys Ile Phe Phe Gly Val Thr 
                85                  90                  95      

Ala Ser Ser Val Leu Ser Tyr Ser Ile Cys Tyr Ala Phe Leu Pro Leu 
            100                 105                 110         

Phe Ser Ile Arg Phe Ile Ile Leu Phe Ile Leu Leu Ser Thr Phe Leu 
        115                 120                 125             

Ile Leu Leu Pro Arg Ile Thr Trp Gln Leu Ile Tyr Ser Arg Arg Lys 
    130                 135                 140                 

Lys Gly Ser Gly Asp Gly Glu His Arg Arg Thr Phe Leu Ile Gly Ala 
145                 150                 155                 160 

Gly Asp Gly Gly Ala Leu Phe Met Asp Ser Tyr Gln His Pro Thr Ser 
                165                 170                 175     

Glu Leu Glu Leu Val Gly Ile Leu Asp Lys Asp Ser Lys Lys Lys Gly 
            180                 185                 190         

Gln Lys Leu Gly Gly Ile Pro Val Leu Gly Ser Tyr Asp Asn Leu Pro 
        195                 200                 205             

Glu Leu Ala Lys Arg His Gln Ile Glu Arg Val Ile Val Ala Ile Pro 
    210                 215                 220                 

Ser Leu Asp Pro Ser Glu Tyr Glu Arg Ile Leu Gln Met Cys Asn Lys 
225                 230                 235                 240 

Leu Gly Val Lys Cys Tyr Lys Met Pro Lys Val Glu Thr Val Val Gln 
                245                 250                 255     

Gly Leu His Gln Ala Gly Thr Gly Phe Gln Lys Ile Asp Ile Thr Asp 
            260                 265                 270         

Leu Leu Gly Arg Gln Glu Ile Arg Leu Asp Glu Ser Arg Leu Gly Ala 
        275                 280                 285             

Glu Leu Thr Gly Lys Thr Ile Leu Val Thr Gly Ala Gly Gly Ser Ile 
    290                 295                 300                 

Gly Ser Glu Ile Cys Arg Gln Val Ser Arg Phe Asn Pro Glu Arg Ile 
305                 310                 315                 320 

Val Leu Leu Gly His Gly Glu Asn Ser Ile Tyr Leu Val Tyr His Glu 
                325                 330                 335     

Leu Ile Arg Lys Phe Gln Gly Ile Asp Tyr Val Pro Val Ile Ala Asp 
            340                 345                 350         

Ile Gln Asp Tyr Asp Arg Leu Leu Gln Val Phe Glu Gln Tyr Lys Pro 
        355                 360                 365             

Ala Ile Val Tyr His Ala Ala Ala His Lys His Val Pro Met Met Glu 
    370                 375                 380                 

Arg Asn Pro Lys Glu Ala Phe Lys Asn Asn Ile Arg Gly Thr Tyr Asn 
385                 390                 395                 400 

Val Ala Lys Ala Val Asp Glu Ala Lys Val Ser Lys Met Val Met Ile 
                405                 410                 415     

Ser Thr Asp Lys Ala Val Asn Pro Pro Asn Val Met Gly Ala Thr Lys 
            420                 425                 430         

Arg Val Ala Glu Leu Ile Val Thr Gly Phe Asn Gln Arg Ser Gln Ser 
        435                 440                 445             

Thr Tyr Cys Ala Val Arg Phe Gly Asn Val Leu Gly Ser Arg Gly Ser 
    450                 455                 460                 

Val Ile Pro Val Phe Glu Arg Gln Ile Ala Glu Gly Gly Pro Val Thr 
465                 470                 475                 480 

Val Thr Asp Phe Arg Met Thr Arg Tyr Phe Met Thr Ile Pro Glu Ala 
                485                 490                 495     

Ser Arg Leu Val Ile His Ala Gly Ala Tyr Ala Lys Asp Gly Glu Val 
            500                 505                 510         

Phe Ile Leu Asp Met Gly Lys Pro Val Lys Ile Tyr Asp Leu Ala Lys 
        515                 520                 525             

Lys Met Val Leu Leu Ser Gly His Thr Glu Ser Glu Ile Pro Ile Val 
    530                 535                 540                 

Glu Val Gly Ile Arg Pro Gly Glu Lys Leu Tyr Glu Glu Leu Leu Val 
545                 550                 555                 560 

Ser Thr Glu Leu Val Asp Asn Gln Val Met Asp Lys Ile Phe Val Gly 
                565                 570                 575     

Lys Val Asn Val Met Pro Leu Glu Ser Ile Asn Gln Lys Ile Gly Glu 
            580                 585                 590         

Phe Arg Thr Leu Ser Gly Asp Glu Leu Lys Gln Ala Ile Ile Ala Phe 
        595                 600                 605             

Ala Asn Gln Thr Thr His Ile Glu 
    610                 615     

<210>   4925
<211>   300
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4925
atgaaaatca aagagcaaac taggaaacta gctgcgggca gctcaaaaca ctgttttaag   60
gttgtagatg gaactgacga agtcagctca aaacactgtt ttaaggttgt ggatggaact   120
gacgaagtca gctcaaaaca ctgttttgag gttgtggata gaactgacga agtcagctca   180
aaacactgtt ttgaggttgt ggatagaact gacgaagtca gctcaaaaca ctgttttgag   240
gttgtggata gaactgacga agtcagtaac catatacggc aaggcgacgt tgacgtggtt   300

<210>   4926
<211>   100
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   box element

<400>   4926
Met Lys Ile Lys Glu Gln Thr Arg Lys Leu Ala Ala Gly Ser Ser Lys 
1               5                   10                  15      

His Cys Phe Lys Val Val Asp Gly Thr Asp Glu Val Ser Ser Lys His 
            20                  25                  30          

Cys Phe Lys Val Val Asp Gly Thr Asp Glu Val Ser Ser Lys His Cys 
        35                  40                  45              

Phe Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys Phe 
    50                  55                  60                  

Glu Val Val Asp Arg Thr Asp Glu Val Ser Ser Lys His Cys Phe Glu 
65                  70                  75                  80  

Val Val Asp Arg Thr Asp Glu Val Ser Asn His Ile Arg Gln Gly Asp 
                85                  90                  95      

Val Asp Val Val 
            100 

<210>   4927
<211>   630
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4927
atgacctcta tcacagcgat ttttttcgat ttggatggaa ccctcgttga tagttctatc   60
gggattcaca atgcctttac ctataccttt aaagagctgg gggtgcctag ccctgatgcc   120
aaaactattc gtggttttat gggaccacct ctcgaaagta gttttgcgac ctgcctgtcc   180
aaagaccaaa tttctgaagc cgtgcagata tatcgttctt actataaggc aaaaggcatc   240
tatgaagctc aactctttcc tcagattata gacttgcttg aggagttatc gagcagttat   300
ccactctaca tcaccacgac aaaggataca tctactgctc aagacatggc aaaaaacttg   360
gaaatccatc atttctttga tggcatttat ggttctagcc ctgaagcacc ccataaggca   420
gatgtcattc accaagcctt gcagacacat caactagcac cagaacaagc catcatcatc   480
ggagatacca agtttgatat gctgggagct cgagaaacag gtattcagaa attggccatc   540
acttggggat ttggagagca agcagatcta ctaaactatc aacctgatta tatcgctcac   600
aaacccttag aagttttggc gtattttcaa                                    630

<210>   4928
<211>   210
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hydrolase, haloacid dehalogenase-like family
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902137 (e-119)

<400>   4928
Met Thr Ser Ile Thr Ala Ile Phe Phe Asp Leu Asp Gly Thr Leu Val 
1               5                   10                  15      

Asp Ser Ser Ile Gly Ile His Asn Ala Phe Thr Tyr Thr Phe Lys Glu 
            20                  25                  30          

Leu Gly Val Pro Ser Pro Asp Ala Lys Thr Ile Arg Gly Phe Met Gly 
        35                  40                  45              

Pro Pro Leu Glu Ser Ser Phe Ala Thr Cys Leu Ser Lys Asp Gln Ile 
    50                  55                  60                  

Ser Glu Ala Val Gln Ile Tyr Arg Ser Tyr Tyr Lys Ala Lys Gly Ile 
65                  70                  75                  80  

Tyr Glu Ala Gln Leu Phe Pro Gln Ile Ile Asp Leu Leu Glu Glu Leu 
                85                  90                  95      

Ser Ser Ser Tyr Pro Leu Tyr Ile Thr Thr Thr Lys Asp Thr Ser Thr 
            100                 105                 110         

Ala Gln Asp Met Ala Lys Asn Leu Glu Ile His His Phe Phe Asp Gly 
        115                 120                 125             

Ile Tyr Gly Ser Ser Pro Glu Ala Pro His Lys Ala Asp Val Ile His 
    130                 135                 140                 

Gln Ala Leu Gln Thr His Gln Leu Ala Pro Glu Gln Ala Ile Ile Ile 
145                 150                 155                 160 

Gly Asp Thr Lys Phe Asp Met Leu Gly Ala Arg Glu Thr Gly Ile Gln 
                165                 170                 175     

Lys Leu Ala Ile Thr Trp Gly Phe Gly Glu Gln Ala Asp Leu Leu Asn 
            180                 185                 190         

Tyr Gln Pro Asp Tyr Ile Ala His Lys Pro Leu Glu Val Leu Ala Tyr 
        195                 200                 205             

Phe Gln 
    210 

<210>   4929
<211>   450
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4929
ttggatttcc tctttgctgc tggtgccttt ggactagtca tcgcaaacaa tgcctccatc   60
tcaggtgctg agggtgggtg tcaagctgaa gttggttcag cctctgctat gagtgctgcc   120
gccttgactc tggctgcagg tggaacacct tatcaggcca gtcaagctat tgcctttgtc   180
attaaaaata tgctaggcct catctgtgac cctgttgcag gtttggtcga agttccctgt   240
gtcaaacgta atgccatggg agctagcttt gctttcatcg cagcagacat ggccttggca   300
ggtatcgaat ctaaaatccc tgtggatgaa gtgatcgatg ccatgtacca agtaggagca   360
agcatgccaa ctgcctttcg tgaaacagct gaaggtggac tcgctaccac ccctactggt   420
cgtcgcctcc aaaaagaaat tttcggagaa                                    450

<210>   4930
<211>   150
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   L-serine dehydratase, iron-sulfur-dependent, alpha subunit, END OVERLAP
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15902138 (e-161)

<400>   4930
Met Asp Phe Leu Phe Ala Ala Gly Ala Phe Gly Leu Val Ile Ala Asn 
1               5                   10                  15      

Asn Ala Ser Ile Ser Gly Ala Glu Gly Gly Cys Gln Ala Glu Val Gly 
            20                  25                  30          

Ser Ala Ser Ala Met Ser Ala Ala Ala Leu Thr Leu Ala Ala Gly Gly 
        35                  40                  45              

Thr Pro Tyr Gln Ala Ser Gln Ala Ile Ala Phe Val Ile Lys Asn Met 
    50                  55                  60                  

Leu Gly Leu Ile Cys Asp Pro Val Ala Gly Leu Val Glu Val Pro Cys 
65                  70                  75                  80  

Val Lys Arg Asn Ala Met Gly Ala Ser Phe Ala Phe Ile Ala Ala Asp 
                85                  90                  95      

Met Ala Leu Ala Gly Ile Glu Ser Lys Ile Pro Val Asp Glu Val Ile 
            100                 105                 110         

Asp Ala Met Tyr Gln Val Gly Ala Ser Met Pro Thr Ala Phe Arg Glu 
        115                 120                 125             

Thr Ala Glu Gly Gly Leu Ala Thr Thr Pro Thr Gly Arg Arg Leu Gln 
    130                 135                 140                 

Lys Glu Ile Phe Gly Glu 
145                 150 

<210>   4931
<211>   141
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4931
atccgtcgga gccaatgggt tgaagtaact cttgttcaaa gtggttttac gatttcaaga   60
actcctctca gttctgagga cacggtaatg attgatgcga cggaagtaca aatcaatcgc   120
cctaaaaaaa gaattagcga a                                             141

<210>   4932
<211>   47
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1381, transposase OrfA, truncation FRAMESHIFT
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903933 (2.E-86)

<400>   4932
Ile Arg Arg Ser Gln Trp Val Glu Val Thr Leu Val Gln Ser Gly Phe 
1               5                   10                  15      

Thr Ile Ser Arg Thr Pro Leu Ser Ser Glu Asp Thr Val Met Ile Asp 
            20                  25                  30          

Ala Thr Glu Val Gln Ile Asn Arg Pro Lys Lys Arg Ile Ser Glu 
        35                  40                  45          

<210>   4933
<211>   831
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4933
atgtctaatt catttgtcaa gttgttagtc tctcaattat ttgcaaattt agcagatatt   60
ttctttagag taacaatcat tgctaacata tacattattt caaaatcagt aattgccaca   120
tcactagttc ctatcttaat aggaatatcc tcttttgttg cgagtctttt agttccgttg   180
gttactaaaa ggttagcgct aaatagggtt ttatctttat ctcaatttgg aaagactata   240
ttattggcga tactggtagg aatgtttacc gtaatgcaat ccgtagcgcc tttggtgacc   300
tatctatttg ttgttgcaat ttccatacta gatggttttg cagcacccgt ttcctatgct   360
attgtgccac gctatgcgac cgatttgggt aaggctaatt cagccttatc aatgactggt   420
gaagctgttc aattgatagg ttggggatta ggtggactct tgtttgcaac aattggtctg   480
ttacctacca cgtgtatcaa tttagtcttg tatatcattt ctagctttct gatgttattt   540
cttcctaacg ctgaagtgga ggtgttagag tcagaaacta atcttgaaat tttgctcaaa   600
ggttggaagt tagttgctag aaatcctaga ttaagacttt ttgtatcagc aaatttattg   660
gaaatttttt caaatacgat ttgggtttct tccattatac ttgtttttgt aacggagtta   720
ttaaataaaa cggaaagtta ctggggatat tctaatacag catactctat tggtattata   780
attagtggct taattgcttt taggctatct gaaaagttcc ttgctgctaa a            831

<210>   4934
<211>   277
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein, interruption
<223>   Cellular location: membrane
<223>   Similar to strain R6 sequence 15904027 (e-113)

<400>   4934
Met Ser Asn Ser Phe Val Lys Leu Leu Val Ser Gln Leu Phe Ala Asn 
1               5                   10                  15      

Leu Ala Asp Ile Phe Phe Arg Val Thr Ile Ile Ala Asn Ile Tyr Ile 
            20                  25                  30          

Ile Ser Lys Ser Val Ile Ala Thr Ser Leu Val Pro Ile Leu Ile Gly 
        35                  40                  45              

Ile Ser Ser Phe Val Ala Ser Leu Leu Val Pro Leu Val Thr Lys Arg 
    50                  55                  60                  

Leu Ala Leu Asn Arg Val Leu Ser Leu Ser Gln Phe Gly Lys Thr Ile 
65                  70                  75                  80  

Leu Leu Ala Ile Leu Val Gly Met Phe Thr Val Met Gln Ser Val Ala 
                85                  90                  95      

Pro Leu Val Thr Tyr Leu Phe Val Val Ala Ile Ser Ile Leu Asp Gly 
            100                 105                 110         

Phe Ala Ala Pro Val Ser Tyr Ala Ile Val Pro Arg Tyr Ala Thr Asp 
        115                 120                 125             

Leu Gly Lys Ala Asn Ser Ala Leu Ser Met Thr Gly Glu Ala Val Gln 
    130                 135                 140                 

Leu Ile Gly Trp Gly Leu Gly Gly Leu Leu Phe Ala Thr Ile Gly Leu 
145                 150                 155                 160 

Leu Pro Thr Thr Cys Ile Asn Leu Val Leu Tyr Ile Ile Ser Ser Phe 
                165                 170                 175     

Leu Met Leu Phe Leu Pro Asn Ala Glu Val Glu Val Leu Glu Ser Glu 
            180                 185                 190         

Thr Asn Leu Glu Ile Leu Leu Lys Gly Trp Lys Leu Val Ala Arg Asn 
        195                 200                 205             

Pro Arg Leu Arg Leu Phe Val Ser Ala Asn Leu Leu Glu Ile Phe Ser 
    210                 215                 220                 

Asn Thr Ile Trp Val Ser Ser Ile Ile Leu Val Phe Val Thr Glu Leu 
225                 230                 235                 240 

Leu Asn Lys Thr Glu Ser Tyr Trp Gly Tyr Ser Asn Thr Ala Tyr Ser 
                245                 250                 255     

Ile Gly Ile Ile Ile Ser Gly Leu Ile Ala Phe Arg Leu Ser Glu Lys 
            260                 265                 270         

Phe Leu Ala Ala Lys 
        275         

<210>   4935
<211>   252
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4935
atgaaactaa cttatgatga taaagttcag atctatgaac ttagaaaaca aggatatagc   60
ttagagaagc tttcaaataa atttgggata aacaattcta atattaggta catgattaaa   120
ttgattgatc gttacggaat agagttcgtc aaaaaaggaa aaaatcgtta ctattctcct   180
gatttaaaac aagaaatgat taatcccaaa tcattcatac ctctctcaac tagatgtaac   240
ttacaaaacc cc                                                       252

<210>   4936
<211>   84
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS3-Spn1, hypothetical protein, interruption
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903492 (4.E-82)

<400>   4936
Met Lys Leu Thr Tyr Asp Asp Lys Val Gln Ile Tyr Glu Leu Arg Lys 
1               5                   10                  15      

Gln Gly Tyr Ser Leu Glu Lys Leu Ser Asn Lys Phe Gly Ile Asn Asn 
            20                  25                  30          

Ser Asn Ile Arg Tyr Met Ile Lys Leu Ile Asp Arg Tyr Gly Ile Glu 
        35                  40                  45              

Phe Val Lys Lys Gly Lys Asn Arg Tyr Tyr Ser Pro Asp Leu Lys Gln 
    50                  55                  60                  

Glu Met Ile Asn Pro Lys Ser Phe Ile Pro Leu Ser Thr Arg Cys Asn 
65                  70                  75                  80  

Leu Gln Asn Pro 
                

<210>   4937
<211>   186
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4937
aatgaaaatc acaacaggct cattcataga tggttaccta agcctaaggg aactaagaaa   60
acgactacca aggaagtcgc attcatcgaa aagtagatta acaactatcc taaaaaatgc   120
ttgaactaca agtcccccag agaagacttc tggatgacta acttgaactt gaaatttagc   180
aataat                                                              186


<210>   4938
<400>   4938
000

<210>   4939
<211>   243
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4939
atggggtgga attttcgtgt cgtaaatcta ctatctctac attcccaaac aaaaaacccc   60
agcataagca gggcatctaa gcatttaatt caaagtaaaa tacaaaccaa acgacatagg   120
tcacgaggag gagaaaaagc gagtagagag tcacaaaggt cattttccac aagaacttgg   180
tttgtcgtcg ttccagtttg gcaaatagaa gattccccgc ataaacgcaa gcaacaaaaa   240
caa                                                                 243

<210>   4940
<211>   81
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence-induced protein Ccs1 (ccs1)
<223>   Cellular location: cytoplasm

<400>   4940
Met Gly Trp Asn Phe Arg Val Val Asn Leu Leu Ser Leu His Ser Gln 
1               5                   10                  15      

Thr Lys Asn Pro Ser Ile Ser Arg Ala Ser Lys His Leu Ile Gln Ser 
            20                  25                  30          

Lys Ile Gln Thr Lys Arg His Arg Ser Arg Gly Gly Glu Lys Ala Ser 
        35                  40                  45              


Arg Glu Ser Gln Arg Ser Phe Ser Thr Arg Thr Trp Phe Val Val Val 
    50                  55                  60                  

Pro Val Trp Gln Ile Glu Asp Ser Pro His Lys Arg Lys Gln Gln Lys 
65                  70                  75                  80  

Gln 
    

<210>   4941
<211>   324
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4941
gtggatagta attatttctc agatgacctg gcttttcata gctttagtat gcgcgaagac   60
acaacaggtg aggtattggc gattaccaac aatggacagg aaaaccatct ggttaagatg   120
gcattcttgg aattaaaaaa tacagagaaa ccagcaaaga caaggttcgc aagccatggt   180
tggagttttt cggcaacaag ccctttaccc agcaaccgca acgagccatt acccaagcaa   240
atcaactgct ggactacaag agctggtccg aggaggacag gaaaatgttt agtcaactac   300
atatgcgaga agaacaagtc ttgt                                          324

<210>   4942
<211>   108
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   competence-induced protein Ccs16 (ccs16)
<223>   Cellular location: cytoplasm

<400>   4942
Met Asp Ser Asn Tyr Phe Ser Asp Asp Leu Ala Phe His Ser Phe Ser 
1               5                   10                  15      

Met Arg Glu Asp Thr Thr Gly Glu Val Leu Ala Ile Thr Asn Asn Gly 
            20                  25                  30          

Gln Glu Asn His Leu Val Lys Met Ala Phe Leu Glu Leu Lys Asn Thr 
        35                  40                  45              

Glu Lys Pro Ala Lys Thr Arg Phe Ala Ser His Gly Trp Ser Phe Ser 
    50                  55                  60                  

Ala Thr Ser Pro Leu Pro Ser Asn Arg Asn Glu Pro Leu Pro Lys Gln 
65                  70                  75                  80  

Ile Asn Cys Trp Thr Thr Arg Ala Gly Pro Arg Arg Thr Gly Lys Cys 
                85                  90                  95      

Leu Val Asn Tyr Ile Cys Glu Lys Asn Lys Ser Cys 
            100                 105             

<210>   4943
<211>   174
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4943
atgtggtata atccttttat ggcatattca atagattttc gtaaaaaagt tctctcttat   60
tgtgagcgaa caggtagtat aacagaagca tcacacgttt tccaaatctc acgtaatacc   120
atttatggct ggttaaagct aaaagagaaa acaggagagc taaaccacca agta         174

<210>   4944
<211>   58
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS630-Spn1, transposase Orf1, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902123 (2.E-31)

<400>   4944
Met Trp Tyr Asn Pro Phe Met Ala Tyr Ser Ile Asp Phe Arg Lys Lys 
1               5                   10                  15      

Val Leu Ser Tyr Cys Glu Arg Thr Gly Ser Ile Thr Glu Ala Ser His 
            20                  25                  30          

Val Phe Gln Ile Ser Arg Asn Thr Ile Tyr Gly Trp Leu Lys Leu Lys 
        35                  40                  45              

Glu Lys Thr Gly Glu Leu Asn His Gln Val 
    50                  55              

<210>   4945
<211>   874
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4945
atggcagacg aactaattag tattgtagtt ccaatctaca acgttgagaa ttatttgcga   60
atgtgtttgg atagcattca gaatcagacg tatcaaaatt ttgagtgttt attaatcaat   120
gatggctctc cagatcattc atccaaaata tgtgaagaat ttgtagagaa agattctcgt   180
ttcaaatatt ttgagaaagc aaacggcggt ctttcatcag ctcgtaacct aggtattgaa   240
tgttcggggg ggggcgtaca ttacttttgt agactctgat gattggttgg aacatgatgc   300
tttagaccga ttatatggtg ctttgaaaaa ggaaaacgca gatattagta tcgggcgtta   360
taattcttat gatgaaacac gctatgtgta tatgacttat gttacggatc cagatgattc   420
tctagaagtg atagaaggta aagcaattat ggatagggaa ggtgtcgaag aagtcagaaa   480
tgggaactgg actgtagctg tcttgaagtt attcaagaga gagttactac aagatttacc   540
atttcctata ggaaaaattg cagaggatac ttactggaca tggaaggtac ttctaagagc   600
ttcgaggata gtctatttga atcgttgtgt ttactggtac cgtgttggtt tatctgatac   660
tttatcgaat acatggagtg aaaagcgtat gtatgatgaa attggggcta gggaagaaaa   720
gatagctatt ttagcaagtt cagactatga cttgaccaat catattttga tttataaaaa   780
tagattacaa agagtgatag caaaattaga agaacaaaat atgcagttca cagagattta   840
cagaagaatg atggaaaaat tgtctttact tccg                               874


<210>   4946
<400>   4946
000


<210>   4947
<211>   201
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4947
atgaatactt attgtaatat aaatgaaaca atgctgagtg aggtttatgg aggtaattcc   60
ggaggagcag ctgtagttgc tgctttaggt tgtgcagcgg gtggagtgaa atatgggaga   120
cttctaggac catggggcgc tgcaatagga ggaattggag gagcagtggt ttgtggatat   180
ttagcctata ccgctacatc a                                             201

<210>   4948
<211>   67
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   blpN protein (blpN)
<223>   Cellular location: membrane

<400>   4948
Met Asn Thr Tyr Cys Asn Ile Asn Glu Thr Met Leu Ser Glu Val Tyr 
1               5                   10                  15      

Gly Gly Asn Ser Gly Gly Ala Ala Val Val Ala Ala Leu Gly Cys Ala 
            20                  25                  30          

Ala Gly Gly Val Lys Tyr Gly Arg Leu Leu Gly Pro Trp Gly Ala Ala 
        35                  40                  45              

Ile Gly Gly Ile Gly Gly Ala Val Val Cys Gly Tyr Leu Ala Tyr Thr 
    50                  55                  60                  

Ala Thr Ser 
65          

<210>   4949
<211>   129
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4949
tctagtataa atagcgagaa atatctatcc tatcttctag aatgtcttcc aaacgaggaa   60
actctcgtaa acaaagaggt tttagaggtc tatttaccgt ggactaaagt tgtacaagaa   120
aagtgcaaa                                                           129

<210>   4950
<211>   43
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS66 family element, Orf3, internal deletion
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902370 (2.E-19)

<400>   4950
Ser Ser Ile Asn Ser Glu Lys Tyr Leu Ser Tyr Leu Leu Glu Cys Leu 
1               5                   10                  15      

Pro Asn Glu Glu Thr Leu Val Asn Lys Glu Val Leu Glu Val Tyr Leu 
            20                  25                  30          

Pro Trp Thr Lys Val Val Gln Glu Lys Cys Lys 
        35                  40              

<210>   4951
<211>   156
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4951
atgtcgtata gtagaagtgt attattctag tttcaatata ctatagtagc tcagaagtcg   60
gtacttaaac gtgctatatc aaaaccagtc ctggaaaaac gtggactggt ttcgtgtttg   120
gattattacc ttgaacgaca tgcgttaaaa gttagt                             156


<210>   4952
<400>   4952
000

<210>   4953
<211>   86
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4953
gtgctatatc aaaaccagtc cttgaaaaac gtggactggt ttcgtgtttg gattattacc   60
ttgaacgaca tgcgttaaaa gttagt                                        86


<210>   4954
<400>   4954
000

<210>   4955
<211>   618
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4955
atggcacaaa agactcatag tttatcatac acaaagtgga ggtgttctat catattgtgt   60
tcacccctaa gtatagacga aaagtcatct ataatcaata tagaagtagt ttagacgaaa   120
tatttcatcg cttgtgtagt tataaaggtg ttgaaatgat cgagggtcac ttaatgccag   180
accatgtaca catgttagtc agtattccgt cgaggctaag tgtttcaagt tttatggggt   240
atttaaaagg caaaagtgca ctcatgatgt ttgacaaaca cgccaatctc aagtacaagt   300
ttgggaatcg gcatttctgg gaggaaggtt attatgtaag tccagtaggg cttaatgaag   360
ccacaattaa gaaatatagt caagattaaa gaaattatcg agtggatgat ttcttcatga   420
gtatgaaaat ttgagaacga gtaaagtatg atatatagta aaatgaaata agaacaggac   480
aaaatcgatc aggacagtca aatcgatttt taacaatgtt ttagaagcag aggtgtacta   540
ttccagtttc aatctactat agcactagat aaattgagtg taaaagaata tgaggatccc   600
tttagggata gtggtaag                                                 618


<210>   4956
<400>   4956
000

<210>   4957
<211>   349
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4957
atggctccga tgacctataa agatacgatg acgagtgact ttttcgaagc ttgcttccaa   60
aaattcttac tacctacttt agatacacca tcccttatca ttatggacaa tgcaaggttt   120
cacagaatga acatgtgtaa ggagcagggc atagactgtt accacttcct acctattcac   180
ccgagtataa tcccattgag aaaatatggg cttacatcaa aaacatctca gaataatatt   240
gtcaaattac gatgcttttc ttgaggcact tttgtcctat tcttgtttca gccgactata   300
ctccgttatt gggcagctac ggaacagtcg atgggacgat ggggggaca               349


<210>   4958
<400>   4958
000

<210>   4959
<211>   237
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4959
atgaatgaac gttaccagtg tttaaaaact aaagaatatc aggcactttt atcttccaag   60
ggtagacaaa ttttcgctaa acgtaagatt gatatgaaat ctgtctttgg gcagataaag   120
gtttgtttgg gttataagag atgtcatctg agaggtaagc gtcaagtgag aattgacatg   180
ggattcgtac tcatggccaa caacctgctg aaatataata agagaaagag gcaaaat      237

<210>   4960
<211>   79
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved domain protein (50S Ribosomal protein)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902920 (3.E-24)

<400>   4960
Met Asn Glu Arg Tyr Gln Cys Leu Lys Thr Lys Glu Tyr Gln Ala Leu 
1               5                   10                  15      

Leu Ser Ser Lys Gly Arg Gln Ile Phe Ala Lys Arg Lys Ile Asp Met 
            20                  25                  30          

Lys Ser Val Phe Gly Gln Ile Lys Val Cys Leu Gly Tyr Lys Arg Cys 
        35                  40                  45              

His Leu Arg Gly Lys Arg Gln Val Arg Ile Asp Met Gly Phe Val Leu 
    50                  55                  60                  

Met Ala Asn Asn Leu Leu Lys Tyr Asn Lys Arg Lys Arg Gln Asn 
65                  70                  75                  

<210>   4961
<211>   147
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4961
gtgcgagtaa aaatcaatct caaatgctcc tcttgtggca gtatcaatta cctaaccagt   60
aaaaattcaa aaacccatcc agacaagatt gaggttttaa agtattgtcc caaggaaaga   120
aaagtaaccc tacatcttga atctaag                                       147

<210>   4962
<211>   49
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L33 (rpmG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903669 (8.E-80)

<400>   4962
Met Arg Val Lys Ile Asn Leu Lys Cys Ser Ser Cys Gly Ser Ile Asn 
1               5                   10                  15      

Tyr Leu Thr Ser Lys Asn Ser Lys Thr His Pro Asp Lys Ile Glu Val 
            20                  25                  30          

Leu Lys Tyr Cys Pro Lys Glu Arg Lys Val Thr Leu His Leu Glu Ser 
        35                  40                  45              

Lys 
    

<210>   4963
<211>   219
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4963
ttgctgctct tttacgttgg caggctgaac ggtcagaagt atcattgtat atcatttgta   60
tcatggcata taaagtatcg ctctatttta ttgatgattt taaaatcgct cttatcatgg   120
cgagccattc aaatttgctc cacaaatgag gaaagtacca ttttaggcta ttcagttgtc   180
aaagggcaaa taaaaaatct cactcatttt caaactcta                          219

<210>   4964
<211>   73
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4964
Met Leu Leu Phe Tyr Val Gly Arg Leu Asn Gly Gln Lys Tyr His Cys 
1               5                   10                  15      

Ile Ser Phe Val Ser Trp His Ile Lys Tyr Arg Ser Ile Leu Leu Met 
            20                  25                  30          

Ile Leu Lys Ser Leu Leu Ser Trp Arg Ala Ile Gln Ile Cys Ser Thr 
        35                  40                  45              

Asn Glu Glu Ser Thr Ile Leu Gly Tyr Ser Val Val Lys Gly Gln Ile 
    50                  55                  60                  

Lys Asn Leu Thr His Phe Gln Thr Leu 
65                  70              

<210>   4965
<211>   309
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4965
atgatagagg cacagggttt cttagtggat aagcaaacaa gatgcattca ttaccatagc   60
aagctggata ttattgcttt acaatgctat gattgtaaaa agtattatgc ttgttatcgg   120
tgtcatgatt cattagaaca tcaccctttt gagccgtatc ccttatcttt gatacaggat   180
aagcctattt tatgtggtgt ttgtctaaaa ctactaacat ataagcaata taaagaaagc   240
ttaagttgcc ccttttgttt ttctcgcttt aatccaggtt gccaaaatca taaggaacgc   300
tattttaaa                                                           309

<210>   4966
<211>   103
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   conserved hypothetical protein
<223>   Cellular location: cytoplasm

<400>   4966
Met Ile Glu Ala Gln Gly Phe Leu Val Asp Lys Gln Thr Arg Cys Ile 
1               5                   10                  15      

His Tyr His Ser Lys Leu Asp Ile Ile Ala Leu Gln Cys Tyr Asp Cys 
            20                  25                  30          

Lys Lys Tyr Tyr Ala Cys Tyr Arg Cys His Asp Ser Leu Glu His His 
        35                  40                  45              

Pro Phe Glu Pro Tyr Pro Leu Ser Leu Ile Gln Asp Lys Pro Ile Leu 
    50                  55                  60                  

Cys Gly Val Cys Leu Lys Leu Leu Thr Tyr Lys Gln Tyr Lys Glu Ser 
65                  70                  75                  80  

Leu Ser Cys Pro Phe Cys Phe Ser Arg Phe Asn Pro Gly Cys Gln Asn 
                85                  90                  95      

His Lys Glu Arg Tyr Phe Lys 
            100             

<210>   4967
<211>   150
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4967
atggcactaa aaaaagcaag cctagcttgt gcggtttgtg gttcgagaaa ctattcaatc   60
aagatcagcg gaaacctcaa gcctacacga ctagaagtaa ataaattttg taagcattgt   120
ggcaagtaca ctacacacag agaaacgaga                                    150

<210>   4968
<211>   50
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   ribosomal protein L33 (rpmG)
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15903864 (2.E-25)

<400>   4968
Met Ala Leu Lys Lys Ala Ser Leu Ala Cys Ala Val Cys Gly Ser Arg 
1               5                   10                  15      

Asn Tyr Ser Ile Lys Ile Ser Gly Asn Leu Lys Pro Thr Arg Leu Glu 
            20                  25                  30          

Val Asn Lys Phe Cys Lys His Cys Gly Lys Tyr Thr Thr His Arg Glu 
        35                  40                  45              

Thr Arg 
    50  

<210>   4969
<211>   282
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4969
atggaacaat tacattttat cacaaaatta ctagacatta aagaccctaa tgtccagatt   60
ttaaacatca tcaataagga tacacacaag gaaatcatcg ccaaactgga ctacgacgcc   120
ccatcttgcc ctgagtgcgg aaaccaattg aagaaatatg actttcaaaa accttctaaa   180
attccttatc ttgaaacgac tggtatgcct acaagaattc tccttagaaa gcgtcgattc   240
aagtgctatc actgttcaaa aatgatggtc gctgaaactt ct                      282

<210>   4970
<211>   94
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   IS1167, transposase, truncation
<223>   Cellular location: cytoplasm
<223>   Similar to strain R6 sequence 15902073 (2.E-52)

<400>   4970
Met Glu Gln Leu His Phe Ile Thr Lys Leu Leu Asp Ile Lys Asp Pro 
1               5                   10                  15      

Asn Val Gln Ile Leu Asn Ile Ile Asn Lys Asp Thr His Lys Glu Ile 
            20                  25                  30          

Ile Ala Lys Leu Asp Tyr Asp Ala Pro Ser Cys Pro Glu Cys Gly Asn 
        35                  40                  45              

Gln Leu Lys Lys Tyr Asp Phe Gln Lys Pro Ser Lys Ile Pro Tyr Leu 
    50                  55                  60                  

Glu Thr Thr Gly Met Pro Thr Arg Ile Leu Leu Arg Lys Arg Arg Phe 
65                  70                  75                  80  

Lys Cys Tyr His Cys Ser Lys Met Met Val Ala Glu Thr Ser 
                85                  90                  

<210>   4971
<211>   1341
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4971
atgaaggaga tttttatggc taaaaaaggt accctaacag gtttgctcct gtttggaata   60
ttttttggtg cggggaactt gatttttccg ccttctctag gtgctctatc tggagaacat   120
tttcttcctg ccatcgcagg ttttgtcttt tcaggcgttg gtatcgccgt cttgaccctt   180
attattggaa cgctaaatcc taaaggatat atctacgaga tttcaacgaa gatagcgcct   240
tggtttgcga ctctttacct ctcagttctt tacttgtcaa tcggtccatt ctttgctacc   300
ccacgtactg ctacaacagc ttacgaagta gggattagcc cccttttgtc ggatgcaaat   360
aaaggacttg gcttgattgt atttacggtt ctgtattttg cggcagccta tttgatttcg   420
cttaatccat caaaaatctt agaccgcatt ggacgtattt taacgccagt ctttgcaatt   480
ttgattgtta tcttggtcgt tctgggagct atcaaatatg gtggaacaag tcctcaagct   540
gcttcagctg cttatcaagc ttctgccttt ggtacaggtt tcctagaagg ttacaatacc   600
ttggacgccc ttgcctcagt ggcctttagc gtaatcgcag ttcaaacctt gaaacaactt   660
ggattttcaa gtaagaaaga atacatttca actatttggg ttgttggtat cgttgttgcc   720
cttgccttca gcgctcttta catcggttta ggttttcttg gaaatcattt cccagtacca   780
gctgaagcga tgaagggtgg aacaccaggt gtttacatct tgtcacaagc cactcaagaa   840
atctttggct caacagctca actcttcctt gcagctatgg ttaccgtaac ctgcttcaca   900
acgactgttg gtttgattgt gtcaacagct gagttcttta atgagcgctt cccacaaatc   960
agctacaagg tttatgcgac agcctttacc ttgattggat ttgctattgc caatttgggt   1020
cttgatgcga ttatcaagta ctcaattcca gtactggtta tcttgtaccc aatcacgatt   1080
gctatcgtta tgattgtcat tgtcaacaaa tttgttgccc tttcaaaacc aggtatgcag   1140
ttgacaattg ctgtggttac agttattgcc attgcaagcg tactaggaag ctcgtttaag   1200
gttgagtttc ttgcaaatct tgttagcgtt cttccttttg ccaaggcatc tctcccatgg   1260
ttggtgccag ccattgttgg aatcttgctc tcattggttc taccaaacaa gcaagaaagc   1320
gatgtttttg aaatggaata a                                             1341

<210>   4972
<211>   446
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   branched-chain amino acid transport system II carrier protein
        (brnQ)

<400>   4972
Met Lys Glu Ile Phe Met Ala Lys Lys Gly Thr Leu Thr Gly Leu Leu 
1               5                   10                  15      

Leu Phe Gly Ile Phe Phe Gly Ala Gly Asn Leu Ile Phe Pro Pro Ser 
            20                  25                  30          

Leu Gly Ala Leu Ser Gly Glu His Phe Leu Pro Ala Ile Ala Gly Phe 
        35                  40                  45              

Val Phe Ser Gly Val Gly Ile Ala Val Leu Thr Leu Ile Ile Gly Thr 
    50                  55                  60                  

Leu Asn Pro Lys Gly Tyr Ile Tyr Glu Ile Ser Thr Lys Ile Ala Pro 
65                  70                  75                  80  

Trp Phe Ala Thr Leu Tyr Leu Ser Val Leu Tyr Leu Ser Ile Gly Pro 
                85                  90                  95      

Phe Phe Ala Thr Pro Arg Thr Ala Thr Thr Ala Tyr Glu Val Gly Ile 
            100                 105                 110         

Ser Pro Leu Leu Ser Asp Ala Asn Lys Gly Leu Gly Leu Ile Val Phe 
        115                 120                 125             

Thr Val Leu Tyr Phe Ala Ala Ala Tyr Leu Ile Ser Leu Asn Pro Ser 
    130                 135                 140                 

Lys Ile Leu Asp Arg Ile Gly Arg Ile Leu Thr Pro Val Phe Ala Ile 
145                 150                 155                 160 

Leu Ile Val Ile Leu Val Val Leu Gly Ala Ile Lys Tyr Gly Gly Thr 
                165                 170                 175     

Ser Pro Gln Ala Ala Ser Ala Ala Tyr Gln Ala Ser Ala Phe Gly Thr 
            180                 185                 190         

Gly Phe Leu Glu Gly Tyr Asn Thr Leu Asp Ala Leu Ala Ser Val Ala 
        195                 200                 205             

Phe Ser Val Ile Ala Val Gln Thr Leu Lys Gln Leu Gly Phe Ser Ser 
    210                 215                 220                 

Lys Lys Glu Tyr Ile Ser Thr Ile Trp Val Val Gly Ile Val Val Ala 
225                 230                 235                 240 

Leu Ala Phe Ser Ala Leu Tyr Ile Gly Leu Gly Phe Leu Gly Asn His 
                245                 250                 255     

Phe Pro Val Pro Ala Glu Ala Met Lys Gly Gly Thr Pro Gly Val Tyr 
            260                 265                 270         

Ile Leu Ser Gln Ala Thr Gln Glu Ile Phe Gly Ser Thr Ala Gln Leu 
        275                 280                 285             

Phe Leu Ala Ala Met Val Thr Val Thr Cys Phe Thr Thr Thr Val Gly 
    290                 295                 300                 

Leu Ile Val Ser Thr Ala Glu Phe Phe Asn Glu Arg Phe Pro Gln Ile 
305                 310                 315                 320 

Ser Tyr Lys Val Tyr Ala Thr Ala Phe Thr Leu Ile Gly Phe Ala Ile 
                325                 330                 335     

Ala Asn Leu Gly Leu Asp Ala Ile Ile Lys Tyr Ser Ile Pro Val Leu 
            340                 345                 350         

Val Ile Leu Tyr Pro Ile Thr Ile Ala Ile Val Met Ile Val Ile Val 
        355                 360                 365             

Asn Lys Phe Val Ala Leu Ser Lys Pro Gly Met Gln Leu Thr Ile Ala 
    370                 375                 380                 

Val Val Thr Val Ile Ala Ile Ala Ser Val Leu Gly Ser Ser Phe Lys 
385                 390                 395                 400 

Val Glu Phe Leu Ala Asn Leu Val Ser Val Leu Pro Phe Ala Lys Ala 
                405                 410                 415     

Ser Leu Pro Trp Leu Val Pro Ala Ile Val Gly Ile Leu Leu Ser Leu 
            420                 425                 430         

Val Leu Pro Asn Lys Gln Glu Ser Asp Val Phe Glu Met Glu 
        435                 440                 445     

<210>   4973
<211>   1161
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4973
atgaagaaaa aatttgccct atcgtttgtg gcgcttgcaa gtgtagcact tcttgcagcc   60
tgtggagaag tgaagtctgg agcagtcaac actgctggta actcagtaga ggaaaagaca   120
attaaaatcg ggtttaactt tgaagaatca ggttctttag ctgcatacgg aacagctgaa   180
caaaaaggtg cccaattggc tgttgatgaa atcaatgccg caggtggtat cgatggaaaa   240
caaatcgaag tagtcgataa agataataag tctgaaacag ctgaggctgc ttcagttaca   300
actaaccttg taacccaatc taaagtatca gcagtcgtag gacctgcgac atctggtgcg   360
actgcagctg cggtagcgaa cgctacaaaa gcaggtgttc cattgatctc accaagtgcg   420
actcaagatg gattgactaa aggtcaagat tacctcttta ttggaacttt ccaagatagc   480
ttccaaggaa aaattatctc aaactatgtt tctgaaaaat taaatgctaa gaaagttgtt   540
ctttacactg acaatgccag tgactatgct aaagggattg caaaatcttt ccgcgagtca   600
tacaagggtg aaatcgttgc agatgaaact ttcgtagcag gtgacacaga cttccaagca   660
gcccttacaa aaatgaaagg gaaagacttt gatgctatcg ttgttcctgg ttactataat   720
gaggctggta aaattgtaaa ccaagcgcgt ggcatgggaa ttgacaaacc aatcgttggt   780
ggtgatggat tcaacggtga ggagtttgta caacaagcaa ctgctgaaaa agcatcaaac   840
atctacttta tctcaggctt ctcaactact gtagaagttt cagctaaagc taaagccttc   900
cttgacgctt accgtgctaa gtacaatgaa gagccttcaa catttgcagc cttggcttat   960
gattcagttc accttgtagc aaacgcagca aaaggtgcta aaaattcagg tgaaatcaag   1020
aataaccttg ctaaaacaaa agattttgaa ggtgtaactg gtcaaacaag cttcgatgca   1080
gaccacaaca cagtcaaaac tgcttacatg atgaccatga acaatggtaa agttgaagca   1140
gcagaagttg taaaaccata a                                             1161

<210>   4974
<211>   386
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   branched-chain amino acid ABC transporter, amino acid-binding
        protein (livJ)

<400>   4974
Met Lys Lys Lys Phe Ala Leu Ser Phe Val Ala Leu Ala Ser Val Ala 
1               5                   10                  15      

Leu Leu Ala Ala Cys Gly Glu Val Lys Ser Gly Ala Val Asn Thr Ala 
            20                  25                  30          

Gly Asn Ser Val Glu Glu Lys Thr Ile Lys Ile Gly Phe Asn Phe Glu 
        35                  40                  45              

Glu Ser Gly Ser Leu Ala Ala Tyr Gly Thr Ala Glu Gln Lys Gly Ala 
    50                  55                  60                  

Gln Leu Ala Val Asp Glu Ile Asn Ala Ala Gly Gly Ile Asp Gly Lys 
65                  70                  75                  80  

Gln Ile Glu Val Val Asp Lys Asp Asn Lys Ser Glu Thr Ala Glu Ala 
                85                  90                  95      

Ala Ser Val Thr Thr Asn Leu Val Thr Gln Ser Lys Val Ser Ala Val 
            100                 105                 110         

Val Gly Pro Ala Thr Ser Gly Ala Thr Ala Ala Ala Val Ala Asn Ala 
        115                 120                 125             

Thr Lys Ala Gly Val Pro Leu Ile Ser Pro Ser Ala Thr Gln Asp Gly 
    130                 135                 140                 

Leu Thr Lys Gly Gln Asp Tyr Leu Phe Ile Gly Thr Phe Gln Asp Ser 
145                 150                 155                 160 

Phe Gln Gly Lys Ile Ile Ser Asn Tyr Val Ser Glu Lys Leu Asn Ala 
                165                 170                 175     

Lys Lys Val Val Leu Tyr Thr Asp Asn Ala Ser Asp Tyr Ala Lys Gly 
            180                 185                 190         

Ile Ala Lys Ser Phe Arg Glu Ser Tyr Lys Gly Glu Ile Val Ala Asp 
        195                 200                 205             

Glu Thr Phe Val Ala Gly Asp Thr Asp Phe Gln Ala Ala Leu Thr Lys 
    210                 215                 220                 

Met Lys Gly Lys Asp Phe Asp Ala Ile Val Val Pro Gly Tyr Tyr Asn 
225                 230                 235                 240 

Glu Ala Gly Lys Ile Val Asn Gln Ala Arg Gly Met Gly Ile Asp Lys 
                245                 250                 255     

Pro Ile Val Gly Gly Asp Gly Phe Asn Gly Glu Glu Phe Val Gln Gln 
            260                 265                 270         

Ala Thr Ala Glu Lys Ala Ser Asn Ile Tyr Phe Ile Ser Gly Phe Ser 
        275                 280                 285             

Thr Thr Val Glu Val Ser Ala Lys Ala Lys Ala Phe Leu Asp Ala Tyr 
    290                 295                 300                 

Arg Ala Lys Tyr Asn Glu Glu Pro Ser Thr Phe Ala Ala Leu Ala Tyr 
305                 310                 315                 320 

Asp Ser Val His Leu Val Ala Asn Ala Ala Lys Gly Ala Lys Asn Ser 
                325                 330                 335     

Gly Glu Ile Lys Asn Asn Leu Ala Lys Thr Lys Asp Phe Glu Gly Val 
            340                 345                 350         

Thr Gly Gln Thr Ser Phe Asp Ala Asp His Asn Thr Val Lys Thr Ala 
        355                 360                 365             

Tyr Met Met Thr Met Asn Asn Gly Lys Val Glu Ala Ala Glu Val Val 
    370                 375                 380                 

Lys Pro 
385     

<210>   4975
<211>   1260
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4975
atgaaagtct ttcagcatgt aaatatcgtg acttgtgatc aagatttcca tgtttatctt   60
gatggaatct tagcagtcaa ggattctcaa atcgtctatg tcggtcaaga taagccagcg   120
tttttagagc aagctgagca gattatagac tatcagggag cttggattat gcctggtttg   180
gtcaattgtc acacccattc tgcaatgaca ggtctgagag ggatccgaga tgacagcaat   240
ctccatgaat ggctcaatga ctatatttgg ccagcagaat ctgagtttac tcccgacatg   300
actaccaatg cggtcaaaga agccctgaca gagatgctcc agtcaggaac aacaaccttt   360
aacgatatgt ataatcccaa tggtgtggat atccagcaaa tttatcaggt ggtgaaaact   420
tccaagatgc gttgttattt ttctccgact ctcttttctt cagagacaga aacaactgct   480
gagactataa gtagaactcg atccatcata gacgaaatct taaaatataa aaatccaaat   540
ttcaaggtta tggtagcacc tcattctccg tatagctgca gtagagactt gctggaagcg   600
agtttggaaa tggcaaaaga gctaaatatt ccgctccatg tccatgtggc ggagaccaag   660
gaggagtcag gaattatcct caaacgatac ggcaaacgcc cccttgcttt tcttgaagaa   720
ctgggttatt tagatcatcc gtccgtattt gctcacgggg tcgaattaaa cgagagagaa   780
attgaacgct tggcatcttc tcaagtggct atcgcccaca atcctatcag taacctcaaa   840
ctggcatcag gaattgctcc aattatccag ctccaaaaag cgggagtagc agtcggaatt   900
gcgactgact cggttgcttc caataacaat ctagatatgt ttgaggaagg aaggactgca   960
gctcttcttc agaagatgaa aagtggggat gccagccagt ttccaatcga aacagctctc   1020
aaggtactga caatcgaagg ggctaaggtc cttggaatgg aaaatcagat aggaagtctg   1080
gaagtcggca agcaagcaga ttttctggtc attcaaccac aagggaaaat tcatctccaa   1140
cctcaggaaa atatgctgtc tcacctggtt tatgcagtta aatctagtga tgtagatgat   1200
gtttatatcg ccggagaaca ggttgttaag caaggtcaag tcctgacagt agaactttaa   1260

<210>   4976
<211>   419
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   Atz/Trz family protein

<400>   4976
Met Lys Val Phe Gln His Val Asn Ile Val Thr Cys Asp Gln Asp Phe 
1               5                   10                  15      

His Val Tyr Leu Asp Gly Ile Leu Ala Val Lys Asp Ser Gln Ile Val 
            20                  25                  30          

Tyr Val Gly Gln Asp Lys Pro Ala Phe Leu Glu Gln Ala Glu Gln Ile 
        35                  40                  45              

Ile Asp Tyr Gln Gly Ala Trp Ile Met Pro Gly Leu Val Asn Cys His 
    50                  55                  60                  

Thr His Ser Ala Met Thr Gly Leu Arg Gly Ile Arg Asp Asp Ser Asn 
65                  70                  75                  80  

Leu His Glu Trp Leu Asn Asp Tyr Ile Trp Pro Ala Glu Ser Glu Phe 
                85                  90                  95      

Thr Pro Asp Met Thr Thr Asn Ala Val Lys Glu Ala Leu Thr Glu Met 
            100                 105                 110         

Leu Gln Ser Gly Thr Thr Thr Phe Asn Asp Met Tyr Asn Pro Asn Gly 
        115                 120                 125             

Val Asp Ile Gln Gln Ile Tyr Gln Val Val Lys Thr Ser Lys Met Arg 
    130                 135                 140                 

Cys Tyr Phe Ser Pro Thr Leu Phe Ser Ser Glu Thr Glu Thr Thr Ala 
145                 150                 155                 160 

Glu Thr Ile Ser Arg Thr Arg Ser Ile Ile Asp Glu Ile Leu Lys Tyr 
                165                 170                 175     

Lys Asn Pro Asn Phe Lys Val Met Val Ala Pro His Ser Pro Tyr Ser 
            180                 185                 190         

Cys Ser Arg Asp Leu Leu Glu Ala Ser Leu Glu Met Ala Lys Glu Leu 
        195                 200                 205             

Asn Ile Pro Leu His Val His Val Ala Glu Thr Lys Glu Glu Ser Gly 
    210                 215                 220                 

Ile Ile Leu Lys Arg Tyr Gly Lys Arg Pro Leu Ala Phe Leu Glu Glu 
225                 230                 235                 240 

Leu Gly Tyr Leu Asp His Pro Ser Val Phe Ala His Gly Val Glu Leu 
                245                 250                 255     

Asn Glu Arg Glu Ile Glu Arg Leu Ala Ser Ser Gln Val Ala Ile Ala 
            260                 265                 270         

His Asn Pro Ile Ser Asn Leu Lys Leu Ala Ser Gly Ile Ala Pro Ile 
        275                 280                 285             

Ile Gln Leu Gln Lys Ala Gly Val Ala Val Gly Ile Ala Thr Asp Ser 
    290                 295                 300                 

Val Ala Ser Asn Asn Asn Leu Asp Met Phe Glu Glu Gly Arg Thr Ala 
305                 310                 315                 320 

Ala Leu Leu Gln Lys Met Lys Ser Gly Asp Ala Ser Gln Phe Pro Ile 
                325                 330                 335     

Glu Thr Ala Leu Lys Val Leu Thr Ile Glu Gly Ala Lys Val Leu Gly 
            340                 345                 350         

Met Glu Asn Gln Ile Gly Ser Leu Glu Val Gly Lys Gln Ala Asp Phe 
        355                 360                 365             

Leu Val Ile Gln Pro Gln Gly Lys Ile His Leu Gln Pro Gln Glu Asn 
    370                 375                 380                 

Met Leu Ser His Leu Val Tyr Ala Val Lys Ser Ser Asp Val Asp Asp 
385                 390                 395                 400 

Val Tyr Ile Ala Gly Glu Gln Val Val Lys Gln Gly Gln Val Leu Thr 
                405                 410                 415     

Val Glu Leu 
            

<210>   4977
<211>   849
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4977
atgaatacaa atctcaagcc caaacttcag cgttttgctt ctgcgactgc ctttgcctgt   60
cctatctgtc aagaaaatct gactctgtta gagactaatt tcaagtgctg caaccgtcat   120
tcttttgact tggcgaaatt tggctatgtc aatctagtcc ctcaaatcaa gcaatctgct   180
aactacgaca aggaaaattt tcaaaaccgt caacaaatcc tagaagccgg cttttaccaa   240
gctatcttag atgctgtatc tgacttgctt gcaagctcaa aaactaccac aacaattttg   300
gatatcggtt gtggtgaagg attctattct cgcaaactac aagaaagtca ctctgaaaaa   360
actttctatg cctttgacat ctccaaagat tcagtccaaa tcgctgctaa aagtgaaccc   420
aactgggcag tcaattggtt cgttggcgac ttggcacgac ttcctataaa agacgctaac   480
atggatattc tgcttgatat cttctcacct gccaactatg gagaatttcg tcgcgtttta   540
tccaaagacg gtatcttgat aaaggttatc ccaactgaaa atcacctcaa agaaatccgt   600
caaagagtac aggaccagct gacaaacaag gagtattcta accaagatat caaggagcat   660
ttccaggaac actttaccat cctatctagt caaactgcct ctctgactaa gactatcaca   720
gcagaacaac tccaagccct actcagtatg actcctctcc tctttcacgt tgaccagagc   780
aaaattgact ggagcaaact gacagagatt accatcgaag cagagatttt ggttgggaaa   840
gcattctaa                                                           849

<210>   4978
<211>   282
<212>   PRT
<213>   Streptococcus pneumoniae

<220>
<223>   rRNA (guanine-N1-)-methyltransferase (rrmA)

<400>   4978
Met Asn Thr Asn Leu Lys Pro Lys Leu Gln Arg Phe Ala Ser Ala Thr 
1               5                   10                  15      

Ala Phe Ala Cys Pro Ile Cys Gln Glu Asn Leu Thr Leu Leu Glu Thr 
            20                  25                  30          

Asn Phe Lys Cys Cys Asn Arg His Ser Phe Asp Leu Ala Lys Phe Gly 
        35                  40                  45              

Tyr Val Asn Leu Val Pro Gln Ile Lys Gln Ser Ala Asn Tyr Asp Lys 
    50                  55                  60                  

Glu Asn Phe Gln Asn Arg Gln Gln Ile Leu Glu Ala Gly Phe Tyr Gln 
65                  70                  75                  80  

Ala Ile Leu Asp Ala Val Ser Asp Leu Leu Ala Ser Ser Lys Thr Thr 
                85                  90                  95      

Thr Thr Ile Leu Asp Ile Gly Cys Gly Glu Gly Phe Tyr Ser Arg Lys 
            100                 105                 110         

Leu Gln Glu Ser His Ser Glu Lys Thr Phe Tyr Ala Phe Asp Ile Ser 
        115                 120                 125             

Lys Asp Ser Val Gln Ile Ala Ala Lys Ser Glu Pro Asn Trp Ala Val 
    130                 135                 140                 

Asn Trp Phe Val Gly Asp Leu Ala Arg Leu Pro Ile Lys Asp Ala Asn 
145                 150                 155                 160 

Met Asp Ile Leu Leu Asp Ile Phe Ser Pro Ala Asn Tyr Gly Glu Phe 
                165                 170                 175     

Arg Arg Val Leu Ser Lys Asp Gly Ile Leu Ile Lys Val Ile Pro Thr 
            180                 185                 190         

Glu Asn His Leu Lys Glu Ile Arg Gln Arg Val Gln Asp Gln Leu Thr 
        195                 200                 205             

Asn Lys Glu Tyr Ser Asn Gln Asp Ile Lys Glu His Phe Gln Glu His 
    210                 215                 220                 

Phe Thr Ile Leu Ser Ser Gln Thr Ala Ser Leu Thr Lys Thr Ile Thr 
225                 230                 235                 240 

Ala Glu Gln Leu Gln Ala Leu Leu Ser Met Thr Pro Leu Leu Phe His 
                245                 250                 255     

Val Asp Gln Ser Lys Ile Asp Trp Ser Lys Leu Thr Glu Ile Thr Ile 
            260                 265                 270         

Glu Ala Glu Ile Leu Val Gly Lys Ala Phe 
        275                 280         

<210>   4979
<211>   2162598
<212>   DNA
<213>   Streptococcus pneumoniae

<400>   4979
tggaatccgc ccaggtgaaa aactctacga agaactcttg gtatcaaccg aactcgttga   60
taatcaagtt atggataaga ttttcgttgg taaggttaat gtcatgcctt tagaatccat   120
caatcaaaag attggagagt tccgcactct cagtggagat gagttgaagc aagctattat   180
cgcctttgct aatcaaacaa cccacattga ataaaaaaga aaaacgcata gtatcaagtt   240
acacaacctt ggtaatatgc gttttattat gtagagactt atactcttcg aaaatctctt   300
caaaccacgt caacgtcgcc ttgccgtata tggttactga cttcgtcagt tctatccaca   360
acctcaaaac agtgttttga gctgacttcg tcagttctat ccacaacctc aaaacagtgt   420
tttgagctga cttcgtcagt tctatccaca acctcaaaac agtgttttga gctgacttcg   480
tcagttccat ccacaacctt aaaacagtgt tttgagctga cttcgtcagt tccatctaca   540
accttaaaac agtgttttga gctgcccgca gctagtttcc tagtttgctc tttgattttc   600
attgagtatt acttcatttt cttctgaaat ggaattgtta cccagtctat gctattgaaa   660
atacgccaaa acttctaagg gtttgtgagc gatataatca ggttgatagt ttagtagatc   720
tgcttgctct ccaaatcccc aagtgatggc caatttctga atacctgttt ctcgagctcc   780
cagcatatca aacttggtat ctccgatgat gatggcttgt tctggtgcta gttgatgtgt   840
ctgcaaggct tggtgaatga catctgcctt atggggtgct tcagggctag aaccataaat   900
gccatcaaag aaatgatgga tttccaagtt ttttgccatg tcttgagcag tagatgtatc   960
ctttgtcgtg gtgatgtaga gtggataact gctcgataac tcctcaagca agtctataat   1020
ctgaggaaag agttgagctt catagatgcc ttttgcctta tagtaagaac gatatatctg   1080
cacggcttca gaaatttggt ctttggacag gcaggtcgca aaactacttt cgagaggtgg   1140
tcccataaaa ccacgaatag ttttggcatc agggctaggc acccccagct ctttaaaggt   1200
ataggtaaag gcattgtgaa tcccgataga actatcaacg agggttccat ccaaatcgaa   1260
aaaaatcgct gtgatagagg tcatggtttc tcctatttga taagcttatt ctccgaaaat   1320
ttctttttgg aggcgacgac cagtaggggt ggtagcgagt ccaccttcag ctgtttcacg   1380
aaaggcagtt ggcatgcttg ctcctacttg gtacatggca tcgatcactt catccacagg   1440
gattttagat tcgatacctg ccaaggccat gtctgctgcg atgaaagcaa agctagctcc   1500
catggcatta cgtttgacac agggaacttc gaccaaacct gcaacagggt cacagatgag   1560
gcctagcata tttttaatga caaaggcaat agcttgactg gcctgataag gtgttccacc   1620
tgcagccaga gtcaaggcgg cagcactcat agcagaggct gaaccaactt cagcttgaca   1680
cccaccctca gcacctgaga tggaggcatt gtttgcgatg actagtccaa aggcaccagc   1740
agcaaagagg aaatccaatt gttgctcgtg gctgaggtct aatttttcaa tagcagcagt   1800
gagaacggat ggcagacagc cagcacttcc agcggttgga gtggcacaga ccaagcccat   1860
tttggcattg tgttcattga ctgcgatggc atttcgggca gccgagagaa tcgtataatc   1920
tgacagagtt tttccgtttt cgatgtagtg atccaatttg gcagcatctc cacctgtcag   1980
gccactacga gatttatttt cattgaggcc aagttggaca gaggctttca taacttccag   2040
attgcgttcc atgagaagga agacttcttc acgttcgcga ccggtcaatt caaactctgt   2100
tgtaatcatg agttctgcga catttccttg aaagtccaga tctgcttgct cgaccaattc   2160
tttgatagaa taaaacatgc ttcctcctat ttaaagaaat tgacattgtg gagatgaggg   2220
atttttcgaa tttcttcgat agcctcatca cagttgcgac tgtcaacttc gataatcata   2280
atggcttttt caccagcttt ttcacgagtg acattcatct gggcgatatt gataccatag   2340
cgggaaagcg cctctgtaac aagggcaatc atacctggaa tatcttgatg aacgatgatg   2400
atagtcggtg tattcatatt gagagagacg gcaaaaccat tgagttcggt tacctgaata   2460
tttcctccac cgatagaaat accagtcacg ctgatggtct tgtgggcatt tttaacagta   2520
attttagtgg tgttagggtg aggggcattg ctgtctttct gaatggtcca gacaatcttg   2580
ataccacgct tgtgggcaat ttccagacta tttggaattt caggatcatc tgtatccatt   2640
cctaaaatac ctgcaacaag ggctaggtct gttccgtgac cacgataggt cttggcaaat   2700
gagttaaaaa gttggaattc aacttctgtc ggagtatcat caaaaatgga agagacaatc   2760
ttcccaatac gaacagcacc agcggtatgg ctactagatg ggccaatcat aactggtccg   2820
atgatatcaa agacagattg aaaacgaagt gatttcatca gtttcccctt ataaaaattc   2880
ttatctctat tatatcaaag aatgaggggc ttggctttaa ttgtggatga aaacctttct   2940
aatacctcaa atagcataaa aatagtatct tttatgacaa aaaacacctt atttagggaa   3000
ataaaaaata attttgtaat atttctacat aaaagtgtca agaaacggta atatttaaag   3060
ggtatgatag aactatagaa agaaggagaa ttttcgaata tgaaatcaat aactaaaaag   3120
attaaagcaa ctcttgcagg agtagctgcc ttgtttgcag tatttgctcc atcatttgta   3180
tctgctcaag aatcatcaac ttacactgtt aaagaaggtg atacactttc agaaatcgct   3240
gaaactcaca acacaacagt tgaaaaattg gcagaaaaca accacattga taacattcat   3300
ttgatttatg ttgatcaaga gttggttatc gatggccctg tagcgcctgt tgcaacacca   3360
gcgccagcta cttatgcggc accagccgct caagatgaaa ctgtttcagc tccagtagca   3420
gaaactccag tagtaagtga aacagttgtt tcaactgtaa gcggatctga agcagaagcc   3480
aaagaatgga tcgctcaaaa agaatcaggt ggtagctata cagctacaaa tggacgttat   3540
atcggacgtt accaattaac agattcatac ctgaacggtg actactcagc tgaaaaccaa   3600
gaacgtgtag cagatgccta cgttgcagga cgttacggtt catggactgc tgctaaaaac   3660
ttctggctta acaatggctg gtattaagaa ctaacgaaca aataatatgt aaagagtcga   3720
ggaaatccct cggctttttt atctttcctt cgcttggtaa tagatctcta cttctttttt   3780
gagatgagac agcatagaag tttcctcggt tagctccaga agggagaacc ctttttggat   3840
aagtttagaa tcgtctgtac aaatcccaat agggacatag cagatagcca gcctatcgta   3900
acttttctta ttcttggcgt cctccagtaa agtatagcag atttgcttac acatgttttt   3960
atcttgattg tatagataga gtgtggaaag gttgagcagg attgctattc gcaagtcata   4020
taaacgttga tagtttttat agacttctaa gcgttgcaag attttctcgg attattgaca   4080
aataaacgga cattctgata gacgattgcc ctagcggctt agtgtaaact ttacaaattt   4140
ggcttgtaat ttttttataa aattcacttc agatacttga cagttattat attttcgctt   4200
atgcttatta tatagataaa aggacgggat aggagtttaa aaatttgaaa gcgctatcca   4260
tattgtttat tggactgatt cttgagtaat agttagagtt tgcttaatac tactctggtt   4320
gttcaaggac ctgatacaga agcgcaccat tctcccggtt aagagtaagt tcgttgttaa   4380
aaaatgaaat gagatagaag gaaggtgagt ccaatggact acgatacttg ttgataaatt   4440
actatagctg tttttacgga acagctctcg ataataggag aaataaatca tgagaaaatt   4500
agttaaaatt ggtgttgcat ctttaatggt atgtggtata cttgctacta caaatgcttt   4560
agcagtatgg gttgagggtg gtcaatggaa ctatggagta ggttggacag gaacttttgg   4620
atattctgat tacttacatt ctactcgata tcatacagca actgttagac atgggggtag   4680
aacctctaag gattatgcaa aacctgaggc atgggctaga gcttccctca ccaagattcc   4740
gccaacagga atggaatatt tctatggatt tgagtaaaat tcttccctct cctatttgga   4800
gagggaaaac tgtagtggag gcacttttat gaaaaaaatc agtaatttct gtatgttact   4860
cctgcttctg tgtaccactt tttttgtttt taatgtaaac tatacacgag aagtggttcg   4920
gattcaagaa atgggaaaga ctgtagattc tttggatttg tatttgaaag atattaacga   4980
acctgcagcg tctgttcttc gattttttga ggatgtatca aaggagtata aagtctccat   5040
catcaaaaca gacagtggtg atgaggtggt caagtctggt gtttttgata aagatacctt   5100
cccctaccaa gagtttggga tttcttctct tgattttacc acagatggtg aaggagtcta   5160
tagtaataaa gaaatttcca ataaacttgg tacgattccg acctttctaa aagccaaacc   5220
tattcagctt atgacttttc aaacctatat caaggataca tctcgtagtt taaatggtcg   5280
ctatacgata acttctacac aagagatgga caaggatagg attgtacaga aatggagcga   5340
ttttttcaag atagaccagg ctaccttgct agagccgacc tacaaaagtg cagtggaagt   5400
cataaatcga gatttgcttt tatctgccat tgtttttgtc ttggctattt tgcttcttgt   5460
gttagtgaca gtgtatcaac cgatgatgga gatgaaaaga gttggggtac aaaaattact   5520
tggttttcaa gatagggctg ttttagctga tgttgtaaaa ggcaaccttt acctcctcct   5580
aggtggggct cttgtgatca atctaggcgt gtttttcttg cttgattata agccaaaaga   5640
tttgtttcct atgctgtggt tgtctcattt tttgctgttg cagctttatc tctttatcag   5700
ttggttgact tacctcttaa tccaaaaaat gacaatcagc tctctgctga aaggtttttc   5760
atctttcaaa tttggtctta tcttcaatta tgtgatgaaa atagggacaa ctattttact   5820
gacggcctta ctgattgggg tgggcagaag tttagaacaa gaaaacaaag aacttgctta   5880
tcagcaacag tgggtaagtc aaggtaatta cctgacctta gaaaccttca aactcaatga   5940
taatctgtgg caagaagagc tagcagggtc agggaaatct acagattatt tctatcgatt   6000
ttatcaggat ttggtagaaa aaacgcaggc gggctatgtg cagagtagca gtcttcctgt   6060
aaaaaatttt gtccaatcag aacagattca gcaatatcag ttaacagata cggtggatgt   6120
ttactatgcc aatcgcaatt ttctaaagag caagggattc aagctaccaa ataccggtat   6180
taaaaaagtt attttgatgc cagcaagtac gaaaggtgaa gaagataaaa atcagctctt   6240
ggggaagtta attgcctttc attcgatgaa gtatgaagag cagcaaaaac gaacgataga   6300
ggagatggat gtcgagattg cctattatga aggagattgg tcatttttcc catatagtga   6360
taagcgaaag gaaaatctct ccaatccaat tattagcttg gtcaatgatt ctgatatgat   6420
gtgggatgag aaagcctccc tgtcaacaac tggcttaaat aatccgatta aaattgaaaa   6480
tacggttcaa catcaaaaag agattacaga gttagttgag aaattgtcag atggaaatta   6540
tttaaaattt tcatctattc aagccattca acaagagaaa gtggattctt atcgagatgc   6600
tgttcggaat tttaacctac tctttgcttt gtttggtctc cttagcatga tgatttccta   6660
cttcttacta gtaacaactt tcttattgaa gcgcagggat atcattacca agaagtttat   6720
ggggtggaaa ctggtcgatc gctaccgtcc tctcctcgtt ctgctcttgc tgggctatag   6780
tttccctctt ctagtcttga ttttctttgc ccatgcgttc ttaccacttc tactgtttgc   6840
aggttttaca tgtctggata tactatttgt gctaggctta gcttctagga tggagaaaag   6900
aagtctagta gagttattga aagggggcat cttatgattg agttgaaaaa tattaccaaa   6960
accattgggg gaaaagtgat tttggataac ttatctctca ggattgatca gggggatttg   7020
gtagctattg ttggtaagag tggtagtggg aagtcgacct tgttaaattt attgggtttg   7080
atagatggtg attatagcgg acggtatgag atttttggtc agacaaatct agcggttaat   7140
tctgctaagt cgcaaacaat aatccgtgaa catatctctt atctgtttca aaattttgcc   7200
ctgattgatg atgaaacggt cgagtacaat ctcatgctgg cgctgaaata tgtgaaattg   7260
cctaagaaag acaagctcaa aaaggtggaa gagattttag agagagtagg tttatcagct   7320
actttgcatc aaagggtctc cgagttgtct gggggcgaac aacaacgaat tgcagttgct   7380
agagccatct taaaacccag ccagctgatt ttagccgatg aaccgacagg ttctctggat   7440
cctgaaaata gagatttggt cttgaagttt ctcttagaga tgaatcgaga ggggaaaaca   7500
gtcattatcg tgacccacga tgcttatgta gcccaacaat gtcatcgaat cattgaatta   7560
ggcgagggaa aatgagttcg ttcagcttca tttgaccgac tgaatactca tatttttcag   7620
agagaaatag cataaatagg cctaggaatg atatttttat gtcattttcc tgggtttttc   7680
tgttttaaat tgaaaaaaat tacaatttag gcttgacaaa ggatgcatat agatgtattg   7740
tttatacaaa taaaaggaat aaacataaag taggctttat tatgaataag atgaagaagg   7800
tgttgatgac gatgtttggt ttagtgatgc tccccctact atttgcttgt agcaacaatc   7860
aatcggctgg aattgaagcc atcaagtcca aaggaaaatt ggttgtagcc ctcaatccgg   7920
attttgctcc atttgaatac caaaaagtgg ttgatgggaa aaatcagatt gtgggttcag   7980
atatcgaatt agccaaggct atcgcaacaa aactaggtgt cgaattggaa ctatctccca   8040
tgagttttga taatgtactg gctagtgttc aatcaggaaa agccgacctt gccatatcag   8100
gtgtttctaa gacagatgaa cggagcaagg tgtttgactt ttccattccc tactatactg   8160
caaaaaataa actcattgtc aaaaaatctg acttgactac ttatcagtct gtaaacgact   8220
tggcgcagaa aaaggttgga gcgcagaaag gttcgattca agagacgatg gcgaaagatt   8280
tgctacaaaa ttcttccctc gtatctctgc ctaaaaatgg gaatttaatc acagatttaa   8340
aatcaggaca agtggatgcc gttatctttg aagaacctgt ttccaaggga tttgtggaaa   8400
ataatcctga tttagcaatc gcagacctca attttgaaaa agagcaagat gattcctacg   8460
cggtagccat gaaaaaagat agcaagaaat tgaaagaggc agtcgataaa accattcaaa   8520
agttgaagga gtctggggaa ttagacaaac tcattgagga tgcctttaaa gcatccattg   8580
aaaaatagaa agaaggaaaa gaacatgagt aaagaaaaag taattttggc ctattctggc   8640
ggtttggaca catcagttgc tattacctgg ttaaagaaag actatgatgt tgtttcagtt   8700
tgtatggatg tgggtgaagg gaaagactta gatttcatcc atgataaggc tcttaaggtt   8760
tgggcagtag aatcttatgt cattgatgtt aaggacgaat ttgctacaga ttatgtgcta   8820
gtggctcatc agtcacatgc ctattatgaa caaaagtatc tcttggtatc tgccttgagc   8880
cgccctctga tttctaaaaa attggttgaa atagcgcatc agataggagc gactacaatt   8940
gctcatggtt gtaccggtaa ggggaatgac caagtcgaat accagattgc agtcgctaag   9000
aaagcgaatg aagctaaaaa gtgatggagt gatgggttca gaataagagg ttggtagatt   9060
atcagcctct ttcttgtcgt tgaaaaagtg agatatattg acttttgaaa aaaatgtcat   9120
aattgagttg ggataaacgt aaaagtcata ctttctcgtt aaatcgttcg gcgattctat   9180
gaaaaggtcg aggagctccc tcgacttttt ttataatttc tttggttgat aatgggtctc   9240
tacttctttt ttgagatgag acagcataga agtttcctcg gtcagctcca gaagggagaa   9300
ccctttttgg ataagtttag aatcgtctgt acaaatccca atacggacat agcagatagc   9360
aagcctatcg tagcttttct tattcttggc gtcctccagt aaagtgtagc agatttgctt   9420
acacatgttt ttatcttgat tgtatagata gagtgtggaa aggtttagca ggattgctat   9480
tcgcaagtca tataaatgtt gatagttttt atagacttct aagcgttgca agattttctc   9540
ggattattga caaataaacg gatattctga tagacgattg ccctagcggc ttagtgtaaa   9600
ctttacaaat ttggcttgta atttttttat aaaattcact tcagttactt gacagttatt   9660
atattttcac ttattatata gataaaagga tgggatagga gtttaaaaat ttgaaagcgc   9720
tatccataat cataacgcat aattttctcc ttttcgtgaa aaaagttaac gtaattttga   9780
aatgagctta ataagaggta tgatgtaggt agaaaataaa gataggagaa aaagtatgaa   9840
taaaaaaata ttttgtattc tagtatgtat tatatcattg attagtctag ctataatctt   9900
tccatggggc tggtcgatat aatgtaaggg agcttgagtt gttagtggag gataaaatgt   9960
taagagtaat agtagttatt caatctttag taataatact gcttgctgtt gctttattat   10020
tatctcggaa aaactttgat tcgttaaatg ttgttcttat aatgatgatc gtatcacaat   10080
tgttgttatt agtatatttg ataaaatcag ggaatcagtg attagctgtt atttgaatta   10140
agtaaactgt taagcttcaa gcagtaactg gttttaaata tttaaaataa gataaaggaa   10200
ggaagtctaa tttaggtaac taaacaaagc ctgcgatcac ttgttaggaa accatcctaa   10260
ccatgcttaa taaaaaagga gaaaataaat ggaactcgta ttaccaaata attatgttgc   10320
tcttgagcaa gaagagatga tgtatcttga tgggggtggt gttggtcgta actggtggaa   10380
tagtagaggt agttttgcaa cagttctgga tgtagatttg gccatctata gtggtggtgc   10440
aacaatttat tctgcttatg cgataaaaaa agctatctca gctaatagag gggctattac   10500
gagaacatta cgtagtttaa taattaaaca tgtaggtagt gcagctggcc atttagtcaa   10560
tactgcacta aacgttgcac taactgttac tggattttca ctaggtggag caatcgcata   10620
tggggctgat tgggctgacg gtagcttaga tggttatatt tttgcttaaa atgaaacatt   10680
tttttgcagg aattggtgaa ataaactttg taagttattt attgtatata tgtgtaggaa   10740
tagccccttt ttttcacgta tatataatag gttctgaaat gaattttgtg aaaatagtgt   10800
tatctatttt gggagttata tttgtaagta tgttaactat tgctcgaatt tatcggactt   10860
ttctataaag aatagtttgg acttgaactg tatctaaaaa cagaggttgg tagattatca   10920
gcctctttct tgtcgttgaa aagagtgaga tatattgact tttgaaaaaa atgtcataat   10980
tgagttggga taaacctaaa agtaataata tagtagattg aatctggaat agtccgttat   11040
gactgttaaa atatttctag aaattaattt gactttccta atcgatttgt tcacatcttg   11100
tttcaatcta ctatactttc tcgttaaacc gttcggtaat tcatggtgac atggacacat   11160
agtagtaagc acactatgtg gcttggcaga tctaaaaact gttcccttgc gataagccta   11220
ataagcacaa catagggagt tagagaagcc gactctaatc aaccactttg ggcagtagtg   11280
gtaactgccc cgtgcttttt attttgagaa aatatggagt ttgtcgttga aattacttga   11340
ttgtattttg gattatcaag aaagattcaa tggaaaaaca tgtcaagtat caacgaatta   11400
taagtattta gagattttca aagtgaattt ttgcttgact gatttacatc atttatttga   11460
cttacacaaa atcacacgag attatgctag tcaaacaaaa cctgctattc aagatggtgt   11520
ttttatttta gaagatttta gaaatatcct atgtacaatg atgtaatcga aaggatatct   11580
ttatgtgagt ttatcggcga tatcttctat atctaagcta gcaagttgtt gcatcgtagc   11640
taaggattta tctaaaaata ctatgaaatt ggacgtcata ttttttgagg ataaaaataa   11700
aagatccgca gttttaggtt tacgaagaga caaaagcgga gtatttaaac cagttactct   11760
acattttaca agcgctaaga aatatgctaa agttcgtaaa acagatgtga aagaaatgaa   11820
atggctataa agattgtccg caggcttaag cttgcgtttt ttgttgttta acgaaattaa   11880
aaaacaagct ctctcatcgg aaatgttttt ataggaatga aggaagatga tgctatgttt   11940
aaaaagagaa tcgaaaaggg caaaagtagt atctttatct attttttgga gtagaagctt   12000
atgatataga aatttgtaat aaaaatgtaa tataaaacat ttgacaaata tttacggggg   12060
gagtatactt aatataatta tagtctaaaa atgactatca gaaaagaggt aaatttagat   12120
gaataagaaa aaaatgattt taacaagtct agccagcgtc gctatcttag gggctggttt   12180
tgttacgtct cagcctactt ttgtaagagc agaagaatct ccacaagttg tcgaaaaatc   12240
ttcattagag aagaaatatg aggaagcaaa agcaaaagct gatactgcca agaaagatta   12300
cgaaacggct aaaaagaaag cagaagacgc tcagaaaaag tatgaagatg atcagaagag   12360
aactgaggag aaagctcgaa aagaagcaga agcatctcaa aaattgaatg atgtggcgct   12420
tgttgttcaa aatgcatata aagagtaccg agaagttcaa aatcaacgta gtaaatataa   12480
atctgacgct gaatatcaga aaaaattaac agaggtcgac tctaaaatag agaaggctag   12540
gaaagagcaa caggacttgc aaaataaatt taatgaagta agagcagttg tagttcctga   12600
accaaatgcg ttggctgaga ctaagaaaaa agcagaagaa gctaaagcag aagaaaaagt   12660
agctaagaga aaatatgatt atgcaactct aaaggtagca ctagcgaaga aagaagtaga   12720
ggctaaggaa cttgaaattg aaaaacttca atatgaaatt tctactttgg aacaagaagt   12780
tgctactgct caacatcaag tagataattt gaaaaaactt cttgctggtg cggatcctga   12840
tgatggcaca gaagttatag aagctaaatt aaaaaaagga gaagctgagc taaacgctaa   12900
acaagctgag ttagcaaaaa aacaaacaga acttgaaaaa cttcttgaca gccttgatcc   12960
tgaaggtaag actcaggatg aattagataa agaagcagaa gaagctgagt tggataaaaa   13020
agctgatgaa cttcaaaata aagttgctga tttagaaaaa gaaattagta accttgaaat   13080
attacttgga ggggctgatc ctgaagatga tactgctgct cttcaaaata aattagctgc   13140
taaaaaagct gagttagcaa aaaaacaaac agaacttgaa aaacttcttg acagccttga   13200
tcctgaaggt aagactcagg atgaattaga taaagaagca gaagaagctg agttggataa   13260
aaaagctgat gaacttcaaa ataaagttgc tgatttagaa aaagaaatta gtaaccttga   13320
aatattactt ggaggggctg attctgaaga tgatactgct gctcttcaaa ataaattagc   13380
tactaaaaaa gctgaattgg aaaaaactca aaaagaatta gatgcagctc ttaatgagtt   13440
aggccctgat ggagatgaag aagaaactcc agcgccggct cctcaaccag agcaaccagc   13500
tcctgcacca aaaccagagc aaccagctcc agctccaaaa ccagagcaac cagctcctgc   13560
accaaaacca gagcaaccag ctccagctcc aaaaccagag caaccagctc cagctccaaa   13620
accagagcaa ccagctaagc cggagaaacc agctgaagag cctactcaac cagaaaaacc   13680
agccactcca aaaacaggct ggaaacaaga aaacggtatg tggtatttct acaatactga   13740
tggttcaatg gcaataggtt ggctccaaaa caacggttca tggtactacc taaacgctaa   13800
cggcgctatg gcaacaggtt gggtgaaaga tggagatacc tggtactatc ttgaagcatc   13860
aggtgctatg aaagcaagcc aatggttcaa agtatcagat aaatggtact atgtcaacag   13920
caatggcgct atggcgacag gctggctcca atacaatggc tcatggtact acctcaacgc   13980
taatggtgat atggcgacag gatggctcca atacaacggt tcatggtatt acctcaacgc   14040
taatggtgat atggcgacag gatgggctaa agtcaacggt tcatggtact acctaaacgc   14100
taacggtgct atggctacag gttgggctaa agtcaacggt tcatggtact acctaaacgc   14160
taacggttca atggcaacag gttgggtgaa agatggagat acctggtact atcttgaagc   14220
atcaggtgct atgaaagcaa gccaatggtt caaagtatca gataaatggt actatgtcaa   14280
tggcttaggt gcccttgcag tcaacacaac tgtagatggc tataaagtca atgccaatgg   14340
tgaatgggtt taagccgatt aaattaaatc atgttaagaa catttgacat tttaattttg   14400
aaacaaagat aaggttcgat tgaatagatt tatgttcgta ttctttaggt acctatctta   14460
tgatttcagg aaatgtcatt aaaaaaacga ctcattttct ctaacttgaa aaatagatta   14520
gagaaaatgg gttgttttat ttattatagt tatttgaatg aagataagaa gaaggtatac   14580
tcacatcatt cacataatct gtatattgac tataagtttt aaaaaacaat ttttaagctc   14640
ttccttgtct tctctaacca agcgtgttat aatgaatact gctcaagcga ccttcaatcg   14700
tgaagcacac acgaccttca atcgtgaata aacgaataga tgggagactt accatgagtg   14760
ataactctaa aacacgtgtt gtcgtgggga tgagtggtgg tgttgattcg tcggtgacgg   14820
ctcttttgct caaggagcag ggctacgatg tgatcggtat cttcatgaag aactgggatg   14880
acacagatga aaacggcgtc tgtacggcga ccgaagatta caaggatgtg gttgcggtgg   14940
cagaccagat tggcattccc tactactctg tcaattttga aaaagagtac tgggaccgcg   15000
tttttgagta tttcctagcg gaataccgtg cagggcgcac gccaaatccg gacgttatgt   15060
gcaacaagga aatcaagttc aaggcctttt tggactatgc cataaccttg ggggcagact   15120
atgtagcgac tgggcattat gctcgagtgg cgcgtgatga ggatggtacc gttcacatgc   15180
ttcgtggcgt ggacaatggc aaggatcaga cctatttcct cagccaactt tcgcaagaac   15240
aacttcaaaa aaccatgttc ccactaggac atttggaaaa gcctgaagta cgcagactag   15300
cagaagaagc aggcctttcg actgctaaga agaaagactc gacagggatt tgctttatcg   15360
gagaaaagaa ctttaaaaac tttctcagca actacctgcc agctcagcct ggtcgcatga   15420
tgactgtgga tggtcgcgat atgggcgagc atgcaggtct tatgtactat acaatcggtc   15480
agcgtggcgg actcggtatc ggtgggcaac acggcggtga caatgcccct tggttcgttg   15540
tcggaaaaga tctaagcaag aatattctct atgtaggaca aggattctac catgattcgc   15600
tcatgtcaac tagcctagaa gccagtcaag tccactttac tcgtgaaatg ccagaagagt   15660
ttacgctaga atgtacggct aaattccgtt accgtcagcc tgactctaag gtgaccgttc   15720
atgtcaaagg agaaaagaca gaggtcatct ttgcggaacc acaacgcgcg attacaccag   15780
gacaggcagt tgtcttttac gatggcgaag agtgtctagg tggcggtttg attgacaatg   15840
cttaccgcga tggacaagtt tgtcagtaca tttagattga caaattttct caatttgcta   15900
caataataac agcaatagaa atgatggtca aagctcatgg atgttgcagg cttttttgtc   15960
ctgcacttct ttgtagtttt gactgttttt gtgtcgttta agggaaagga caagaatgac   16020
tcaacaagac tttcggacaa aagtagacaa tacggttttt ggtgttcggg ctacagcctt   16080
gattgtccaa aatcacaagc ttctagttac caaagacaag ggcaagtatt acactattgg   16140
aggtgcgatt caagtcaatg aaagcacgga agacgcggta gtccgtgaag tgaaggaaga   16200
actgggtgtc aaagctcaag ctgggcagct agcttttgtg gttgaaaatc gttttgaagt   16260
ggacggcgtt tcctatcaca atatcgagtt tcattatctg gtggatttgc ttgaagatgc   16320
cccgttgacc atgcaggaag atgagaaaag gcagccctgt gagtggattg acttggataa   16380
gctccagaat atccagctag ttccagtctt tttaaaaaca gccctaccag attgggaagg   16440
ccaactaaga cacattcatc ttgaggaata ggagagaaac atgacttatc attttactga   16500
agaatacgat attattgtaa ttggtgcggg acacgctggg gttgaggctt ccttggccgc   16560
tagccgtatg ggctgtaagg tcctgcttgc gaccatcaat attgaaatgc tggctttcat   16620
gccttgtaat ccctctatcg gtggttctgc caaggggatt gtcgtgcgtg aagtcgatgc   16680
cctcggtggc gagatggcca aaaccattga caagacttac atccagatga agatgctaaa   16740
cacagggaag gggccagctg tccgtgccct tcgtgcgcag gctgacaagg aactttactc   16800
taaggagatg cgcaagacgg ttgaaaacca agaaaatctg acccttcgtc aaaccatgat   16860
tgatgagatt ttggtggaag atggcaaggt tgtcggtgtg cgtacagcca cccatcaaga   16920
atatgctgct aaggctgtta ttgtgacgac agggactgct ctccgtgggg aaattatcat   16980
cggagacctc aagtactcat caggtcctaa ccacagcttg gcttctatta acctagctga   17040
caatctcaag gaactgggtc tcgaaatcgg tcgtttcaag acaggaaccc ctccacgtgt   17100
caaggcttct tctatcaatt acgatgtgac agaaattcag ccaggagacg aagtgcctaa   17160
tcatttctca tacacttcac gtgatgagga ttatgtcaag gaccaagtac catgctggtt   17220
gacctatacc aatggtacca gtcatgagat tatccaaaac aacctccacc gtgcgcctat   17280
gtttacaggt gtggtcaagg gagtggggcc tcgttactgt ccgtcgattg aagacaagat   17340
tgtgcgcttt gcggacaagg aacgtcacca actcttcctt gagccagaag ggcgcaatac   17400
tgaggaagtc tatgtgcaag gactttcaac cagtctgcct gaggatgtcc agcgtgactt   17460
ggtgcattcc atcaaaggtt tggaaaatgc agagatgatg cggacaggtt atgctattga   17520
gtatgatatg gtcttgcctc atcagttgcg tgcgactttg gaaaccaaga aaatctcagg   17580
tctcttcact gctggtcaga caaatggaac atcaggttac gaagaggcag caggccaagg   17640
gattatcgcg ggtatcaatg cggctctgaa aatccaaggc aagcctgaat tgattttgaa   17700
gcgcagtgat ggttatatcg gggtgatgat cgacgacttg gtgaccaagg gaaccattga   17760
accctaccgt ctcttgacca gtcgtgctga ataccgtctc attcttcgtc atgacaatgc   17820
tgatatgcgc ttgactgaga tgggacgcga gattggcctt gtggacgatg aacgctgggc   17880
tcgttttgaa atcaagaaaa atcaatttga taatgagatg aagcgcctag acagtatcaa   17940
actcaagcca gtcaaggaaa ccaatgccaa ggttgaggag atgggcttca aacccttgac   18000
cgatgcagtg acagccaagg aattccttcg ccgtccagaa gtttcttacc aagatgtggt   18060
ggccttcatc ggaccagctg cagaagactt ggatgacaag attatcgaat tgattgaaac   18120
agaaatcaag tatgaaggct atatttccaa agccatggac caggttgcca agatgaaacg   18180
catggaagaa aaacgcattc cggccaatat cgactgggat gacattgatt ctatcgcaac   18240
cgaagcccgt cagaagttca aactcatcaa tccagaaacc atcggccaag ccagccgtat   18300
ttcgggagta aacccagcag atatttctat tttgatggtg tatctggaag gtaaaaatcg   18360
tagtatttct aaaactcttc aaaaatcaaa atgatacgtc gtcggcttct tacgaatgag   18420
ttcaaagctt ggctttgatt catctccagc ctcccatagt ttcccgaact atgggagcta   18480
actcaagtta tgctttcgct tagccttcta gtctgatttc gatttttatt gatactcttc   18540
gaaaatctct tcaaaccgcg tcaacgtcgc cttgccgtag gtatggctac tgacttcgtc   18600
agttctatct acaacctcaa agcagtgctt tgagcaacct acggctagct tcctagtttg   18660
ctctttgatt ttcattgagt atgagtttta atctcaaaag aaagcataga gaaaaacagc   18720
tccgaggacg gggctgtttt cttgctttat tcttcatctg gtgtgaggat catcgggatg   18780
atgatcggtt cacgttcggt attttcatag aggaaggggc gaatagcgtt gacaatggca   18840
ccattgacag attgcacgct agcatcctta tttttcagtg cgatacgaat ggcattgaag   18900
aggatacgct ggctttggcg aatcaagtcg ccagactctc tcatgtagac aaagcctcgg   18960
ctgaggatgt ctggaccaga tagaatcatc tgcgatttga agtcaacagt tgcaactgcc   19020
agaacgacac cgtcttcaga tagatcgcga cgatctttga ggacagctgc gccaatttca   19080
ccgatacgat ttccatcgac atagatatct tgggcgttga aatgacctgc gatacgagct   19140
gagtcagcag taagggcaag cacatcgcca ttgctcatga taaagatatt gtccttctca   19200
acaccagtat ccactgctag tccagcgtgg actttttgca tgcggtattc accgtggaca   19260
ggcatgaagt attttggctt aatcaagcag agcatgagtt tttgctcttg ctgaccaccg   19320
tgtccagatg tatggatatt gttcacttta ccgtggataa cttcgacacc agcttcagaa   19380
atgatgttaa tcagcttgtt gacactagta gtgtttccag ggatgggact agaagagaag   19440
ataacggtat cacctggttg taattgtact tgacggtggg ttccgttggc gatacgagag   19500
agggctgcca taggctcacc ctgactacct gtacagagga taagaacttc tcctgcagga   19560
taatctttga tttcatttgg ctcgataaag gttcccttag gagctttgat gtagccaaga   19620
tcgattccgt tgacaatggc cttttccata gaacgaccaa agaccgcaat cttgcgtcca   19680
gtcttaacag cagcttctgt tgcctgctgg agacggaaga tatttgaggc aaaggatgca   19740
aagatgatac gtccttcaat accttggata atcttcataa tggactgacc aacgactttt   19800
tcagagttgg taaaggttgg tacttccgca tttgtcgagt cagacaggag acagagcacg   19860
ccttcttcac caagcgcagc catacgatgc aagtccgcag gttctccaac tggagtaaag   19920
tcgaacttaa agtcacccgt acagacgatt ttcccttgag gagtatgaat gacaatcccc   19980
aaaggctctg gaatagagtg agtcgttcta aagaaagttg ccttgagatt tttaaaggtc   20040
aactcggtgt tgtggttgat ttcgtaaagt ttggcgttgc gcaagaggcc gtgttcttcg   20100
agtttcccac ggatcaaagc caaggcaagc ggtccagcat aaatagggac atttgcttgc   20160
ttgagtagga acggaatccc accaatgtgg tcctcgtgtc cgtgtgtgat taaaacagcc   20220
ttgacgcggt cgatattgtc cacgatgtaa gagtagtcag gaatgacata gtcgatacca   20280
agcaagtcat cttctgggaa tttaatccca gcatcgacga tgataatctc gtcttggtat   20340
tcaattccgt aagtgttttt cccgatttct cctagaccac cgatggcaaa aacgccgact   20400
tcttcaggtt taagagtgta ggccatatta gaactccgta atttcgaagg cgccagtttc   20460
tttttcgtaa tcgagcaatt tgtcagacaa gagttcgata tactcgatat tgtactctgg   20520
gcgattttct tcgacaagtt ggcgagcagt gatacggccc tcaagttctg agctggcatc   20580
gatgtctagg taaagcgtgc gtgttgtttc acggcgtggg ctacgttctt ttgtttcttg   20640
ataaaaaact ttgtaaatca tatagttcct ttctatttac aggtcagctt attccaaact   20700
tttagcagat atttgcttga tttcattcca ttttgtgtct agattgacct tgattcgtta   20760
caattatttc aattatacca caaaatgaaa aattagtaaa agacggaaac gagaaagtta   20820
ggggacgatt tctttggtaa gcgttttcaa aaataaagaa aatgtattat gttgataacg   20880
gaagtgaaat ttattgcttg tcataattcc atatagattt taagtcaagg aggttgccct   20940
atgtataact tatttgcttt tgctatcgga gctcgcttgg tagcttttat tgtttttgtt   21000
gcttgcgttt atgcggggaa tcttctattt gccaaactgg aacgacgaca aaccaagttc   21060
ttgtggaaaa tgacctttgt gactctctac tcgctttttc tcctcctcgt gacctatgtc   21120
gtttggtttg tattttactt tgaattaaat gcttagatgc cctgcttatg ctggggtttt   21180
ttgtttggga atgtagagat agtagattta cgacacgaaa attccacccc atctatcaag   21240
atgaggtggt ctttgcattt ttctaacatg acatgacaat ggaattttca aagcttatta   21300
tttttatggg agtcattgtt ctgatcaaaa atagagttga agcataaaaa taaaacaata   21360
caaacagata aatcgaatgg taaagggatg gtagtaatgt tcaaatcatt gagaatgctg   21420
agcaaactgt aagagatgaa gacaataaaa tttatccttc taaaaatgtg tttcttatct   21480
agcatgactt accaaacttt ttacgaaggt cttttccaat ggtataacct gccataaata   21540
aagcgatacc aacaccgaca ccaaagccac ccttgatttc ttgcaattcc ttattagaaa   21600
tttcacgata attgttcaaa tctttcatca tattaatctc ctcctaaaaa ataaccagct   21660
gccaaaccag aacctataag tgctgttcca cctgcaatag ccttccaaga tactgctact   21720
ccaaagataa ccaagggagc gagaccgcca tcaatatctg ataattcatt ttcagataag   21780
gataaaaatt gattgtcaag aatgtcaaaa tttgtcattg aactttcctc cttttttctt   21840
gttcactttt atattcggaa aagaaaagga aaagtgagca tttttttaaa ttatttttag   21900
ttaagtgagg gcactcttgt ctgggggcaa agaaaattcc catgtgccag cttttgtagt   21960
ataatagtaa gcagacaaaa agataggaat gtgttatgaa agtattagct tttgatacgt   22020
ccagcaaggc tctttctctg gctattttag aggataagca ggttcttgcc gagacgacga   22080
ttaatattaa gaaaaatcac agtattactc ttatgcctgc catcgatttt ttgatggcaa   22140
gtttggattg gacacccaag gatttggacc gaatcgtggt agctgaaggg ccgggtagct   22200
atacaggctt gcgaattgcg gtagcaactg ctaagacctt agctcacacc ctgaacatcg   22260
agttggttgg tatgtcgagt ctcttggctc tggtgcccca tcaacaagaa ggtttgtttg   22320
tccccttgat ggatgcgcgt cgcaataatg tttatgcagg attttatgaa aatgccaaac   22380
ctgtcatggc agaagcgcac ctatcttttg aagaggtgct agaaaaagtc aagggtacta   22440
gtcaggtaac ctttgtcgga gaagttggcc cctttgttga gcagattcaa aaacacttgc   22500
caaggactga ttacaaagaa acattgccca atgcagctaa tctagctctt ttggcctggg   22560
acaaggaagc agactccttg catgattttg tgccgaatta cctcaaacga gtcgaggctg   22620
aggaaaactg gctcaagaac cataccgagt ctggcgagtc ttacattaaa cgcctatgat   22680
agaaatcaag cgaattcaac aacagcctga cctagctcaa gccatctacg ctgttatggc   22740
agctgtttac ctagtcagtc cttggactct ggagcaaatc caagcagatc tgtcccaaga   22800
ccagacttgg tatgcattgg cttatgatgg ggcagaagtg attggatttc tagctgtgca   22860
ggagaatctt tttgaagcag aagtcctgca aatcgctgtc aaaggagctt atcagggtca   22920
ggggattgcg tcagccttgt ttgctcaatt gccgacagac aaggaaattt tcctcgaagt   22980
cagacagtca aatcaacgag cgcaagcatt ttacaagaaa gaaaagatga cagttatcgc   23040
tgagcgaaag gcctactacc atgacccagt cgaggacgcc attatcatga agagagaaat   23100
agatgaagga tagatatatt ttagcatttg agacatcctg tgatgagacc agtgtcgccg   23160
tcttgaaaaa cgacgatgag ctcttgtcca atgtcattgc tagtcaaatt gagagtcaca   23220
aacgttttgg tggcgtagtg cccgaagtag ccagtcgtca ccatgtcgag gtcattacag   23280
cctgtatcga ggaggcattg gcagaagcag ggattaccga agaggacgtg acagctgttg   23340
cggttaccta cggaccaggc ttggtcggag ccttgctagt tggtttgtca gctgccaagg   23400
cctttgcttg ggctcacgga cttccactga ttcctgttaa tcacatggct gggcacctca   23460
tggcagctca gagtgtggag cctttggagt ttcccttgct agccctcttg gtcagcggcg   23520
gacacacaga gttggtttat gtttcggagg caggagatta taagattgtt ggggaaaccc   23580
gtgatgatgc ggttggtgag gcttatgata aggtcggccg tgtcatgggc ttgacctatc   23640
ctgcaggtcg tgagattgac gagctggctc atcaggggca ggatatttat gatttccccc   23700
gtgccatgat taaggaagat aatctggagt tctccttctc aggtttgaaa tctgccttta   23760
tcaatcttca tcacaatgcc gagcaaaagg gagaaagcct gtctacagaa gatttgtgtg   23820
cttccttcca agcagcagtt atggacattc tcatggcaaa aaccaagaag gctttggaga   23880
aatatcctgt taaaatccta gttgtggcag gtggtgtggc agccaataaa ggtctcagag   23940
aacgcctagc agccgaaatc acagatgtca aggttatcat cccccctctg cgactctgcg   24000
gagacaatgc aggtatgatt gcctatgcca gcgtcagcga gtggaacaaa gaaaacttcg   24060
caggctggga cctcaatgcc aaaccaagtc ttgcctttga taccatggaa taaagagtgg   24120
ctctttgtca agtgtagtgg gtaggcgaaa agctgcaatc tggagagtac gaaattcgta   24180
ctctcttttt tgatgttcaa agtcatcaaa atccgttttt taaaattgtt aaagttccgg   24240
aaaccaaagg ctttgcgctt gataatctta atcaaattat tggtcgcttc aagtttagcg   24300
ttggaataag gcagcttaag tgcgttgata atcttatctc tatcccttaa aaaagtccaa   24360
aagaccgttt gaaaaagcgg atgaaccgtt ggcagttctt gctcaatcaa tccaaagaaa   24420
tggtcggcat tcttctcttg aaaatgaaag agcaggagtt gatagagttc gtagtgaacc   24480
tgtaatccct cagagtaaga aagcagctta tctcgtactt cccgatgggt taagtgcatt   24540
cgaaacgtgg gctgatagaa tcgtttctga cagagcttga agctatactg gtgtagtaaa   24600
tcagtccagt ggactgattt agcccgagcc tagaaacgaa aaagcgaggg ttccaaaagc   24660
gcttgagcgc ccgatactcc aaggattttc ggtcaaattg gttcatgatt tggattcgta   24720
ctcggttcat agctcggctc agatgttgga caatgtggaa gcggtcaaga acaatcttcg   24780
cctttggaaa gagttgctta gcgagccgat aataagggct gtacatgtcc atggtgatga   24840
cctcgaccag ctcccgaacc tctctctgat agcgttggaa atggtttcga atcaccgcat   24900
gagttcgccc gtctaaaatt gcgaggatgg atttggactc aaaatcttgg gcaatgaagc   24960
tcattttgct ctttttgaag ctatactcat cccaactcat aacttttggc aacttggtcc   25020
aatcggtttc aaacttaaat tccctcagtt ttcggatgac ggtggaagtt gagaccgcca   25080
atctgtgggc aatctcagtc atagactgct tttcaaggag gagctgagcg attttttgtc   25140
tcaccatgtt ggaaatctgg caatttttct tgacaatgga tgtttgagaa acgaccacct   25200
taaggcaatt cttgcactga aagcggcgct ttttgagatg cagtaccgtg ggtaaaccct   25260
gacagtcgag aagcggaatt ttagaggctt tctggaagtc gtatttgatc atcttccctt   25320
gacaatgagg acaaggagga gcgggggaat ccaactttgc ctgaacgact agatgggttt   25380
ggtatttcag aacagacaag attttgatat ttttgtcttc caatccgagc aaatctgtgg   25440
tattcttaag ttgttccata tgaacccttt ctaatgagtt ggttagacgc ttttcattat   25500
aggtcatatg gggctttttt tctacaagaa acgaccctat aattcctggg gtgggattac   25560
ccactacaga aattatagag ccaaaacatt ccaaagtctt gtctgactct ggaatgtttt   25620
ctgttcacag ttgttttgta actgcctaat aagtaaccgc gctataacga ggtatctacc   25680
gagattgtca attctccagt atactgttat aaaaaacaaa actggaggat ttttttatgt   25740
ccccccatcg tcccatcgac tgttccgtag ctgcccaata acggagtata gtcggctgaa   25800
acaagaatag gacaaaagtg cctcaagaaa agcatcgtaa tttgacaata ttattctgag   25860
atgtttttga tgtaagccca tattttctca atgggattat actcgggtga ataggtagga   25920
agtggtaaca gtctatgccc tgctccttac acatgttcat tctgtgaaac cttgcattgt   25980
ccataatgat aagggatggt gtatctaaag taggtagtaa gaatttttgg aagcaagctt   26040
cgaaaaagtc actcgtcatc gtatctttat aggtcatcgg agccatagta tattgaaaca   26100
aaaaagggca ttagtacttc tataacagta tcgcaatctc tggtgtgcgt tgtctcgatc   26160
ttaattcaaa taattatatc ttcttccaga gagactaact gcctgctcaa ggctcgatca   26220
tattcgagat aaaaataggt ctcaacccct gtctcataaa tataaatagg agtcaggtag   26280
cttaagtgat tcaattcttt aaggaaccga tttacttttt ctgggtcttg ttcgcagtag   26340
gtacggctct tttttagact atatcccata gcctttagag cgtaatgaat agttgttgga   26400
ggacagttga attcagcagc tatttcagtc aaataagcat cgggatgagt ttcaatatag   26460
atttttaatt tatctctatc aattttttca attaatagtg gaagttttct tgaagttagt   26520
gtattgaaac gtttttatac agtgctaaaa tttgaagtgt agtgcagatg gatttgtaat   26580
agtattatag caattctttg gagaaggtcg agacaagata aaataggtat ctttgagata   26640
taagcatgat ttactataaa attattgagt tattcataaa aatttctcta tcaaatatca   26700
taatgcgtcg tttaaggaga tggttacaat gcaatatagt tgtggaaaaa taaatattaa   26760
tatccctgat ggatatggag acattaagga tatagtgttt tcggctcata ttatagttag   26820
gtataataat ggacattgtg gaggtataga tccgcatata attggacttt gtaaaaagca   26880
gatcagaagg atgtctctat atcctatttt gataattgta tctagagatt caaaggttat   26940
tgatgattat aaaaatttag atattgccta tgttgattgt actcaatgtt caaataattt   27000
tgaaactgcc ttacacgtta aaaatatttt aaaattatta aaaatccaac ttatacactg   27060
tcatggctac tcaactaatt attttttata tatgttaaaa aaacttgaca agaatggatt   27120
tggaaaggtt aagacagtga taacatgcca tggatgggtt gaatataact taaaaaagaa   27180
attcttgact tattttgatt tttggacata ttctatggga gatgctttta tttgtgtatc   27240
tgaaactatg aaaaaaaaga ttggagagta taataaaaaa taagaagata gttgcaataa   27300
ataacggaat taatgtatca aatagcgatt tagatgtagt aggtgttcaa gactttaaaa   27360
aagaattttg tattccaaat aacaaaaaat catttgttat gttggaaggt tggatccaga   27420
aaaaaggccg gatagattcc ttgaatttgc agaaaaatta tttttagtca gagaagatgt   27480
gatttttatt atggctggaa atggtagtat gtgggctgct ttgaaagaaa aaatttgcca   27540
tttgaaatgt agagataatt tcaggttact tggtgaaatc tatccagcta ctatagttta   27600
ccaaatatcg gatttattgt atattccttc tgatacagaa ggaataccta tgtgtgtttt   27660
agagtcaatg tcacaaggaa ctccggtttt agctagtaat gttggcgggt taagtgaaat   27720
tattgaacat agggttgatg gatttttatt tgagaaggaa gatgttgagg gagtgtgtgc   27780
ttgtgctaat tttttactca atgattctga gtatttgaaa tatataggtg agaatagtaa   27840
atcaaaaata agaaaacatt tttctgtgca aaaaatgttt gtagaaacca tgagagtata   27900
tgatgaatta ttagagaaga gtagtcatgg ataggaatat agatcaagaa ttagtaagta   27960
ttataatacc aacacataat aggtatgaat ctctgattag agctgtgaaa agttgtttac   28020
atcaaagtta taaaaatatc gaagttataa ttattgatga taattatagt aatgtaaatt   28080
taagaaataa aattatccat caatttggct ataccaatca tagaattaag ttaattttaa   28140
gtaatgaaga tttaggtgca actaatgcca gaaacatagg tatcaaaaat tctagaggta   28200
agtatatatc atttttagac gatgatgatg aatatatgcc agatcgaatt ttaaagttga   28260
tggcttgttt taaaaagagt agaatgaaga atttagcttt agtttgtagt tatggaataa   28320
taatttatcc aaatggtaca cgagaagagg agaagaccga ttttgttgga aatcccttgt   28380
ttgttcaaat ggttcacaat atagcaggta cgtcattttg gttgtgtaaa aaagaggtgc   28440
tagaattaat taatggtttt gagaaaatag attcacatca ggacggtgtt gttttattaa   28500
aactacttgt tcaaggatac caaattgata tagtgcgaga attcttggtg aattactacg   28560
ctcacagtaa agaaaacggt atcactggag tgacacaaaa aacaattaat gcagatgaag   28620
aatattataa ttactgtagg aaatatttta atttattgag tttcaacgag agaatattgg   28680
ttacaaagaa atattattct ttaaacataa agcggttact attaatagga gacaaatgca   28740
aggctttaaa agtaatcaag aaggcaagag aagaaaaaat ttttaacgaa tttctttttt   28800
gaaatatatg ttattatatc attttggttt tttctattgt atatatgaaa actatgttca   28860
attaaaattt agaaagtgag aaactattgt gtatactatt ataaaatcaa atataaaaaa   28920
atttagttta ttaacgatat ttattgttgc tggtcaatta ttgctaattt atgcagcaac   28980
tattaatgct ctggtgttga atgaattaat tgcgatgaat ttagagcggt ttttgaaatt   29040
gtcaatctac caaatgattg tctggtgtgg gataatattc cttgactggg tagtgaaaaa   29100
ttatcaggtt gaagtgatcc aagagtttaa tctagagatt cgaaatagag ttgccacaga   29160
catctctaac tctacctatc aagaatttca tagtaaatca tcaggaacat atctttcgtg   29220
gctaaataat gatgttcaga ctttaaatga tcaggcgttt aaacaacttt ttttagtaat   29280
aaaaggaatt tctggtacta tatttgcagt tgtgactctt aatcactatc attggtcatt   29340
gactgtagcc accttgtttt cattaatgat tatgctactt gtaccaaaaa tctttgcatc   29400
gaaaatgcga gaagttagtc taaatttaac taaccaaaat gaagcttttt taaaatctag   29460
tgagactata ttgaatggat ttgatgtgtt agcgtccttg aatcttttat atgtattgcc   29520
taagaaaatt aaagaagcag gaattttatt aaagatggtt atacaaagaa agacaactgt   29580
agaaacgtta gcaggcgcta ttagcttctt tctcaatatt ttttttcaga tatctctcgt   29640
ttttttaaca ggctatcttg caataaaagg aatagtgaaa attggtacta ttgaagcaat   29700
aggagcacta acaggtgtta tttttacagc gctaggtgaa ttaggaggtc aattatcctc   29760
tattattggt acgaagccta tttttttaaa attgtattca attaatccaa ttgagtcaaa   29820
taaaatgaat gatatcgaac caaatgaggt gaatagagat tttccgttat atgaagcaaa   29880
aaatatttgc tataagtatg gagataaaga aatattaaaa aacttaaatt tttgttttca   29940
acgtaatgaa aagtatttaa ttttaggtga aagtggaagc gggaaatcta cattattaaa   30000
attattgaat ggctttttga gagattatag tggagaattg cgattctgcg gggatgatat   30060
aaaaaaaacc tcctatttaa atatggtttc gaatgttcta tatgtagatc aaaaagctta   30120
tttgtttgaa ggtacgatta gagataatat tttattggaa gaaaattata ctgatgaaga   30180
aatactacag tctttagagc aagttggttt gagtgtaaaa gattttccta ataacatttt   30240
agattattat gttggtgatg atgggagatt actgtcagga gggcagaaac aaaaaattac   30300
tttagctaga gggctaatta gaaataagaa aatagtatta attgacgagg gaacttctgc   30360
tatcgatagg agaacttcgt tagcgattga acgtaagata ttagatagag aggatttgac   30420
tgtcattatt gttacccatg ctccgcatcc ggaacttaaa caatatttta ctaagatata   30480
tcaatttcca aaggatttta tttaagaata taggggaggg aaacatgaga ttctattgtg   30540
aagcttatga ggtaattact gaagagaaaa aagtatcatt tttttatgta gatgagaaac   30600
ccttaaggta tctgttattt gactatatat ttctactagt tctagctaaa aaaaaatatc   30660
ccaatcttat gaactgcacc ccaaaagtta gatttattct gtctaacttt tggggtgcag   30720
ttcattttgc atagttttgg cattcatcct agatatccat ataaaatgtc tgagattgtt   30780
gaaatgtcta aaaaaatatc agatctaaac gataaaaaag aatttcacaa aaagaactgt   30840
gagttgaggt ttcaagatag tgttcttgat aacataaata gtgtcccggg tacaactcat   30900
ttatttagtt gtttaaatat tcaaacatta gtaaaaatta ttttatatat ttttcgatac   30960
aacagttgta tgaaaatatt taattttaga gataaagagc ttatcttttt taataagatt   31020
gtaaatgggc tgatacaaaa tattgaggag aatttagagg atgatattga aaggatattg   31080
aaatatttat atatatgttt atttaacgaa atattcatta ttaagaataa ggtgaatttt   31140
tttgatgatg tggaatttaa tcagacactt agtgagtttt tagataaatt gtagagggaa   31200
tggttatgag taacaatact aagtatatct ttttatctcc acatttagat gacgcaattt   31260
tttcctgtgg tgattatatt tcaaaattaa cttcagaagg agaaattgta cttgttatta   31320
ctatattttc tggttaccct ttgagccaac agctacagcc ctctgctaag caatttcata   31380
agttgtgtaa ccttgggaaa tatccgattg aagaaaggaa gaaagaagac aggttagctt   31440
gtgaacgtct acaatgtgat tttagacact tatcgtacta tgaatgtctc tataggaaag   31500
atagaaatgg caattttcta taccgtcata tctatagtga attaaaaaat gaggacacat   31560
taaagaatga tatcataaaa gagctgttaa tgcatttaga cgacaaatgt gtcgtatatt   31620
gtccgctttc acttggtgac catgttgctc atgtttttgt gaatagtatt ggaagggcgc   31680
ttgaatttat gcgttataaa gtaatatatt atgaggactt cccatatgta agtgatagta   31740
gtatggttag ttatatggga aaaactaaag aattaaaaat gtatcaagag gaacttgatg   31800
aaaaaaatta tattgataga atatcatcaa tattgtgcta taaatctcag attttgataa   31860
tctggaaatc agttgaaaaa cttttaaaca atattaaaga gttgtattta aggaatgggg   31920
cagcttattc tattagattt tggattaaga aataaggaag tagttttatg aatatagcag   31980
taattggttt ggggcatgtt gggctggcct acgcgttact atttgcatct aaatataaag   32040
ttgttgcata tgatatagat tctgtaaaaa taaataattt aaaaaagggc attcttccat   32100
ctaaaaatga agagcttatg aagttttttt gcgagaataa cttaaatatt actttttttg   32160
atacattttc tgaaattaaa aataatattg attattatat tattgcgctt ccgacagatt   32220
atgatgagaa aattggtagt tttaatacat atgaaatcga acaaacggta tcgaagattc   32280
tgagggtaaa acctaatgga aagattattt taaagtcaac agttccgatc ggcttttcaa   32340
acaaattaaa aaggctgttt gatacaaaaa atatcatttt tgtccctgaa tttttgagag   32400
aaggttgttc tatatatgat aatttatatc caagtcgcat agttgttgga gatgagacag   32460
ttgaaggaag aaaaattgca gagttgttcc tttcgattag tactcatagt actgccaata   32520
ttaaaaatgt tatgttagtt tctcctactg aagcagaagc aattaagctt ttttctaaca   32580
cattcttagc tctccgtgtt gcttttttaa tgaactagat tcttttgctg agaggagaag   32640
cttaaatgct gaagttgtaa taaaaggtgt ttgtttagat ccaagaattg gaaattttta   32700
taataatcct tcttttggat ttggaggata ttgtcttccc aaagatacta aacaattaaa   32760
aaaagaattt atagaaataa atgccccagt gatagaagcg attgatattt caaacacaaa   32820
tagaaaacag ttcatagtta aacaaatatt ggaacgaaag ccaaagatag taggaatata   32880
taaattgggg atgaaatata attcagataa ttacaaagag tcagctattt taagtataat   32940
taatgaacta ttgattgtcg gtataaaaat tttagtatat gaaccaaatt taaacgttag   33000
tatagataac gtaattattg aaaagaattt tgaactattt acaaaacaaa gtgatctaat   33060
tgttgcaaat agatgggata ggggccttga agcttataaa gataaagttt acacaagggg   33120
gatctggata agagattaac tattgatatt aaaaaggcaa taatttataa aatttgtaca   33180
aaaaaatgtt aaattttcac attttcatag tatactgttt aatagaaagt aggttctttg   33240
taaccgctcc attataaaat cctttcactc ttccggtata ctattaggaa aaacataact   33300
ggaggatatt ttgagctcac acctcatcgt tccagtggct gttccccaag ctcgtgtact   33360
gcccaaaaaa gttagacatt ctatttagaa cgaggattga gttctgtatt gtacaaggct   33420
cggtcctttt agagtcagct taaggctggc ttttttattt tttctaacta tcagaatatt   33480
ttgacaaatg attgtaaata atgatataat atgcaaaagc taggaggtgg tcagatgatt   33540
gagagaatgg aactggggga attttacaag gaattacgtt tggcgagaaa gctcaagcag   33600
tcagatgtgg cttgtgaggg tctaacagct tctcagttgt ccaagtttga actagggcag   33660
tctatgctgt ctgcggataa gttgattcta gctatccaag gtataaatgt gacctttgat   33720
gagtttgggc acaagctcaa caactatcaa gaatctccac atatgcgaat cggtcgaaag   33780
gttgtgaatc gctttgccca tcaggatata gctgctttag agcagctatt ggaggaagtc   33840
gatcaagaac agatggcgca gacctatcgt cgtttgaatg ccatcgtgat taaagatgcc   33900
atccattcac taaataaaag ctacccacta gcagaggagg atagcgagtt tttgaccacc   33960
tatctctatg ctatcgagtc ttggacctgg tttgaactct atctcttttg caataccatg   34020
cccttcttga gcaatcaaga tctgattttt ttatcaacct ccttactcga aaaatccaaa   34080
gaatttaaag agttagtaca caatcgattg tatatgaagc aaggactctt aaatatctta   34140
tcagaactca tggagcgaaa acttttctcc tacatcccaa tcttcgaagc cgagttggag   34200
aggatgttac gaccgtatga tgtttttgaa aaagtatcgt ggcaattttt aaagaagatg   34260
agtgtctttc ttcaaacaaa gggaagcaat caaaaagaga ttgaacgctt tatccaatct   34320
ctgcaggtat tagaaaatcc acaattaata gccctttttg aattgcgttt tcagcaatat   34380
aaagaactta tagattagtt agaaatggca aaataataat aatctcagca acgattttca   34440
ataatgttaa aatttgtttc ttcatatttc tccactcctc attagtagta actttattat   34500
accagagaag taatcaaatt caccaaaatc gcaaatctga aatttctata agaaaaaata   34560
tcaaatatgc gattttctaa aataagccaa tgttcgtgtt atactgtact tgtaaagcac   34620
ttgaagcaaa tcctaggtcg cagaagtggt ttacaaatga agataattga aggagtgtaa   34680
aagatgttaa atttacaatt tgcagaaaca atggaattga cagaagctga gttgcaagat   34740
gttagaggag gcaacctcgt aaattctatg ggaggtggtg gaagaagtgg tatatctggt   34800
tggggcgtcc caggaattta ccctggttgg ggcaatcaag ggatgagtcc taatcgtgga   34860
gcttttgatt ggactataga tttagcagat ggattgtttg gccgccgtag aagataggct   34920
cttataggag ataataggat gaagaaaatg aaagaagtga aatttcacct agcaactggc   34980
ttgttgattt tgacttatta cctcattttt aatgtcacat cagacttaga ttttatggtt   35040
gctttgtctg ataatatgta ctatgtgttc caagttttat tggtacttat tctgggaact   35100
atagctacaa ttgcttttgt caaaagtgaa cattggaaag agtgtggtcg tttccagttt   35160
cgttggtctt acctgggtgt tttccttctt tcttttttct tattgttcgt gtgggcaaat   35220
ctaacaacct atatctttcc tcgtacccag aatggaagta cagtcgtaga agtagccacc   35280
aatttaacag gaattagcta ttttgttacg cgaatacttt atactagtat tatcgcacct   35340
gtatcagaag aggttgtttg tcgtggtctt ttgatgacaa gtttatctaa agttaagaga   35400
tactatcttg atgttcttgt ttccgctgcc atatttggcg ctatgcatgt tttgcagtat   35460
ggttggataa cgacagattt cataaagtat tttggaatgg gcttgatatt ttgtatgatg   35520
tttcgctaca cccgatccat ctattgggct atagctctgc atgcttcatg gaatagtttc   35580
ttactcattg ttactttatt ggtatttgga tattagaaag gtgatatatg aaaaagataa   35640
tctcacaccg ctactttatt atagtttttc tactagttat tgctgaccag aagttcagtg   35700
ttctagtttt acgcagcgac cttgttactg ggctatctga ctttgcctat tatctgtcgg   35760
atatgatgtt gaattttctt gtggttttat ttgctcttat tgctatgatt tggtcgggga   35820
aatggcagaa aatcaatagt agaaagttta aaggatccta tcttttctat tccttcctag   35880
ctctgcttgc ttttgttgtt tggaatttcg ttaccttttt tcttttccca cctactcgaa   35940
atgaaatttc ttatcaacat gctgctccga cttttacagg ggctacagca tttttgatgt   36000
atttttttta tcctgtgatt gcaggtccca tttttgaaga catgatttat cgtggattag   36060
tgatgactgc tctggaaaaa ggaaagaaat gggggctaga tgtacttggt tccgctgttt   36120
tatttggggt ctcgcacatt agtaatcacg gttgggtctt gacagacttt gtcttctata   36180
tgggtggagg tcttatattt gcagtcttat ttagaatgac aaagtcaatt tattggccta   36240
ttggactgca tatagtctac aatggcattg gtcagctttt gatgttactg taattttggt   36300
tgttagtagt atcgcggtct atccttgggg aaagattccc atttgaactt aagaaggagt   36360
tgtgatgaaa gtatttcttc aaaatagaga ttttaggcaa ttaactatca accagtggat   36420
ttcaacgctt ggggatacga ttttttatct ggccttcctg aattatgtgg cagatgcatc   36480
ttttgcccct ttggcgattt tactcatcac gatttcagaa accctgcccc aagttctaca   36540
aatctttctg ggagttttgg cggattttca acatcatcgt gtcttgaaat acacagtcat   36600
tagttttgca aaatttttgc tttactctat agtgtcttta tcactttcag ggcagtcttt   36660
ctccttgttg ctagtagcat ttatttgtct gattaacctc ttgtctgaca cattgagtta   36720
tttttcaggc gccatgctca ctccgatttt cattagaatt attgggcaag accatctggc   36780
agaagctatt ggctttaaac agtcaactgt tagtttagtg aaaacaatca gtaatatcct   36840
aggaggagtc ttactaggca ttctatccat ccagtttatt tccttactga acgctcttac   36900
ctttttaatc gcatttttag gtatcctctt cataaaaact gacctcttga aagtagaaaa   36960
aacgattagc tatcaagaag gactctctgt aaaatccttt tgccagcatt tgctccaatc   37020
atcgaaattg atatggaata tgaataaggt gctcttggtt ttgtttatta tctctactag   37080
tcaagcagtg ataaatgtta cggttcctat ttccactcta tttttaagga accagccctt   37140
tttgaattta caaactggtc aatctcttgc cttgttagcc acactagaat tatcagccct   37200
gattgtcgga agccttgtaa gtggctatct gcaacatacc atttccataa aaacagctct   37260
ctatgcctca cttgtcatcc agttgcttct tctagtagga tttgccacag ttcgttttga   37320
ctggattctc atctttagta ccttggatgc ctttttcgca ggtgttctct ctcctagatt   37380
gcaagaactc gtttttaaac aaatacctga ggagtcaatg ggagcagttc aatcctctat   37440
cggtgccatt acggttgttt tacctagctt atttacaata gctttggtaa ccattgctac   37500
tagctttgga actctggcag ttagctttgt tttattgcta tttcttctag ttgcctttgt   37560
tatgcttctg aatattcgtg aaagtattta gtggagaatt tctataatat atgtttgaga   37620
ctggattgcc agtcttttta tgatggtcaa aatcaacaga cttttttctc ttttctgaat   37680
gtgttataat agactgaatc taaaatagta cgaaacaatt gctaaaacat ttatagaaat   37740
taattttact ttcccaatcg atttgttctc atcttatttc aatctgctat ataatagtcc   37800
atgctgtggt tggattcttt tcagcctact tgtactcttc gaaactctct tcaaaccacg   37860
tcagcttcac tttgccgtag gtatggttac tgacttcgtc agttctatcc acaacctcaa   37920
aacggtgttt tgagctgact tcgtcagttc tatccacaac ctcaaaacag tgttttgagc   37980
tgacttcatc agttctatct gcaacctcaa aacagtgttt tgagcaacct gcggctagtt   38040
tcctagtttg ctctttgatt ttcattgagt attattaaga caatatgagg agaaagatga   38100
aagaaaaagg attttaggag ggggcgcagg cagccatgcc aacggctctt ggctatgtca   38160
gtatcggcct ggcctgtgga attatcggtg cgccctatgt gacacctgtt gagatgggct   38220
tgatgagtct ctttgtttat gctgggagtg cccagtttgc catgttggca ctgattgtgg   38280
ttcaagctcc tgtggcagct attgctatga cggtttttct aatcaacttg cgtctctttt   38340
tgttgagttt acacgcatcg acttatttcc gtcataccag tctttggtac aatatcggta   38400
tgtctagtat cttgacagat gagacctatg gcgttttgat gggtgaattg gcccatacag   38460
acaaggtaaa tcctatgtgg atgcacggaa acaatcttaa cagctatgtg gcttggtttg   38520
tggggacagt agtcggaacg gctctgggtg gcctgctacc aaatccagaa atctttggct   38580
tggattttgc cctggttggg atgtttattg gtatttttgc ttcgcaattt cagattatgc   38640
aaagacggat tcctgtccgc aatctgctca ttatcctagc agttgttgcg gtgtccttct   38700
ttttgctctt gacagtgatg tctcagtcac tagctgttct gtttgcgacg ctacttggtt   38760
gtagcatggg ggtggtttta gatggtcagt aagtatcttt tattagcagt tattttctct   38820
ggcttggtga cttggattcc ccgtatgatt cccttcatct tggtcaagta taagggcctg   38880
cctgcgattg ttgagcgttt tttgaagttt ttgcctgttt ccattatctt tgccctgatt   38940
ctttcaagcg tagtgacagg taaggttggc agtcttcctc aaatcaaatg actggacttc   39000
ttagccgtct ttccaacagc ttgggtagcc tttcgctacc gcaatctagt cggaacagtt   39060
ctctttggag tggtcttgat tgccatcttg cgtttggtct tttaaattac ccataaaaaa   39120
aacttatcac agagatagat atcatataat ggcgtaaatg ctctttttct gttaagatta   39180
taaggtattc tattttggag gaaatgacat gaaaaaaatc gttaaatact catctcttgc   39240
agcccttgct cttgttgctg caggtgtgct tgcggcttgc tcagggggtg ctaagaaaga   39300
aggagaagca gctagcaaga aagaaatcat cgttgcaacc aatggatcac caaagccatt   39360
tatctatgaa gaaaatggcg aattgactgg ttacgagatt gaagtcgttc gcgctatctt   39420
taaagattct gacaaatatg atgtcaagtt tgaaaagaca gaatggtcag gtgtctttgc   39480
tggtcttgac gctgatcgtt acaatatggc tgtcaacaat cttagctaca ctaaagaacg   39540
tgcggagaaa tacctctatg ccgcaccaat tgcccaaaat cctaatgtcc ttgtcgtgaa   39600
gaaagatgac tctagtatca agtctctcga tgatatcggt ggaaaatcga cggaagtcgt   39660
tcaagccact acatcagcta agcagttaga agcatacaat gctgaacaca cggacaaccc   39720
aactatcctt aactatacta aggcagactt gcaacaaatc atggtacgtt tgagcgatgg   39780
acaatttgac tataagattt ttgataaaat cggtgttgaa acagtgatca agaaccaagg   39840
tttggacaac ttgaaagtta tcgaacttcc aagcgaccaa caaccgtacg tttacccact   39900
tcttgctcag ggtcaagatg agttgaaatc gtttgtagac aaacgcatca aagaacttta   39960
taaagatgga actcttgaaa aattgtctaa acaattcttc ggagacactt atctaccggc   40020
agaagctgat attaaataat ttcttgaaat catccattct gagtaaggtg ggtggtttct   40080
cagtttttag ggatatagtt ttaaactata tatctgacta tctaataaca atttgtgaaa   40140
tcaaacaaat tgtgagatac tagtacggta ttatttttaa ggagaaagaa tcatgaaaat   40200
caaaaaatgg cttggtctag cagcccttgc tacagtcgca ggtttggctc ttgcagcttg   40260
cggaaactca gaaaagaaag cagacaatgc aacaactatc aaaatcgcaa ctgttaaccg   40320
tagcggttct gaagaaaaac gttgggacaa aatccaagaa ttggttaaaa aagacggaat   40380
taccttggaa tttacagagt tcacagacta ctcacaacca aacaaagcaa ctgctgatgg   40440
cgaagtagat ttgaacgctt tccaacacta taacttcttg aacaactgga acaaagaaaa   40500
cggaaaagac cttgtagcga ttgcagatac ttacatctct ccaatccgcc tttactcagg   40560
tttgaatgga agtgccaaca agtacactaa agtagaagac atcccagcaa acggagaaat   40620
cgctgtaccg aatgacgcta caaacgaaag ccgtgcgctt tatttgcttc aatcagctgg   40680
cttgattaaa ttggatgttt ctggaactgc tcttgcaaca gttgccaaca tcaaagaaaa   40740
tccaaagaac ttgaaaatca ctgaattgga cgctagccaa acagctcgtt cattgtcatc   40800
agttgacgct gccgttgtaa acaatacctt cgttacagaa gcaaaattgg actacaagaa   40860
atcacttttc aaagaacaag ctgatgaaaa ctcaaaacaa tggtacaaca tcattgttgc   40920
aaaaaaagat tgggaaacat cacctaaggc tgatgctatc aagaaagtaa tcgcagctta   40980
ccacacagat gacgtgaaaa aagttatcga agaatcatca gatggtttgg atcaaccagt   41040
ttggtaataa gaaacaggga ggtgggagag aaaattccac ctcttgcttt tgtatagagt   41100
atagattgta aagaagacta ttcgttcata gaaaggtaga gagaatatgg tttttcctag   41160
cgaacaagaa cagattgaaa aatttgaaaa ggatcatgta gcccagcatt attttgaggt   41220
tttgcgtacc ttgatttcta agaaatcagt ctttgcccag caggttggac tcaaggaagt   41280
cgcaaattat ctgggtgaga ttttcaagcg tgttggagct gaagtggaga ttgatgagag   41340
ctatacagcg ccctttgtca tggcacattt caagagttcg cgtccagatg ccaagacctt   41400
gattttctat aaccactatg acactgtgcc agcggatggg gatcaggtct ggacagagga   41460
tccttttacg ctttcggtcc gcaatggctt catgtatggg cgtggggttg atgacgacaa   41520
gggtcatatc acagctcgct tgagtgcttt gagaaaatat atgcagcacc atgatgattt   41580
acctgtcaat atcagcttta tcatggaggg agcggaggaa tcggcttcaa cagacctaga   41640
taagtatttg gaaaagcatg cagacaaact ccgtggggcg gatttgttgg tctgggaaca   41700
agggaccaaa aatgccttgg aacagctgga aatttctggt ggcaataagg ggattgtgac   41760
ctttgatgcc aaggtaaaaa gcgctgatgt ggatatccac tcgagttatg gtggtgttgt   41820
ggaatcagct ccttggtatc tcctccaagc cttacagtct cttcgtgctg cggatggccg   41880
tatcttggtt gaaggcttgt acgaagaagt acaagagccc aatgaacgag aaatggcctt   41940
gctagaaact tatggtcaac gaaacccaga ggaagttagt cggatttatg gattggagtt   42000
gcctctctta caggaggagc ggatggcctt tctaaaacgt ttctttttcg atccagcgct   42060
taatatcgaa ggaatccagt ctggttatca aggtcagggt gttaagacta ttttacctgc   42120
agaagccagt gccaagctag aggttcgtct ggttccgggc ctagaaccgc atgatgttct   42180
ggaaaaaatt cggaaacagc tagacaaaaa tggctttgat aaggtagaat tatactatac   42240
cttgggagag atgagctatc gaagcgatat gagcgcacca gccattctca atgtgatcga   42300
gttggccaag aaattctatc cacagggcgt ttcagtcttg ccgacgacag cggggacagg   42360
acctatgcat acggtctttg atgccctaga ggtaccaatg gttgcattcg gtctaggaaa   42420
tgccaatagc cgagaccacg gtggagatga aaatgtgcga atcgctgatt attacaccca   42480
tatcgaatta gtagaggagc tgattagaag ctatgagtag agatattatc aagttagatc   42540
agatcgatgt gacttttcac caaaagaaga gaaccatcac agcggttaag gatgtgacca   42600
ttcacatcca agaaggggat atctacggaa tcgttggata ttctggagca ggaaaatcaa   42660
cccttgtacg ggtgattaat ctcttgcaaa aaccatctgc agggaaaatt accattgacg   42720
acgatgtgat ttttgacggc aaggtgacct tgacggcaga gcagttgcgt cgtaaacgtc   42780
aagatatcgg aatgattttc cagcatttta acctgatgag ccaaaagaca gcagaggaga   42840
atgtagcctt tgcccttaaa cactctgaac tcagcaagga agaaaagaag gctaaagtag   42900
ctaagttgtt ggacttggtt ggtttggcag atcgtgctga aaactaccct tcacaactat   42960
ctggagggca aaaacagcgt gtggcaattg cgcgtgcctt ggccaatgat ccaaaaatct   43020
tgatttcaga cgagtcaact tctgcccttg atccgaagac aaccaagcag attttggcct   43080
tgttgcaaga tttgaaccaa aaattaggct tgactgttgt cttgattacg catgaaatgc   43140
agattgtcaa agacattgcc aaccgtgttg cagttatgca ggatgggcat ttgattgaag   43200
agggtagtgt gcttgaaatc ttctcaaacc ctaaacaacc tttgactcaa gactttatct   43260
caacagctac aggtattgac gaagccatgg tcaaaatcga gaagcaagaa atcgtggaac   43320
acttgtctga aaacagtctc ttggtgcaac tcaagtacgc tggagcttca acagacgagc   43380
cacttttgaa tgaattgtac aagcattacc aagtaatggc taatattctc tatgggaata   43440
tcgaaattct cgatggtact cctgttggag aattggtggt ggttttgtca ggtgaaaaag   43500
cagcgttggc aggtgcccaa gaagccattc gtcaagcagg tgtacaacta aaagtattga   43560
agggagtaca gtaagatgga atcattgatt caaacctatt taccaaatgt ctataagatg   43620
ggttgggctg gtcaggcagg ctggggaacg gctatctact taactcttta tatgacagtt   43680
ctttccttca ttatcggagg cttcttgggg ctagtggcag gtctctttct cgtcttgaca   43740
gcgccaggtg gtgtcttgga gaataaagtc gtattctgga ttttagacaa aattacctca   43800
atttttcgtg cggttccctt tatcatcctc ttggcaatct tgtcaccact ttctcacttg   43860
attgttaaaa caagtatcgg gccaaatgca gcccttgtcc cactttcttt tgcagtcttt   43920
gccttctttg cccgtcaggt gcaggttgtc ttggctgaat tggatggcgg tgtcattgag   43980
gcggctcaag cgagcggagc gactttctgg gacatcgtgg gtgtttacct atcagaaggt   44040
cttccagatt tgatccgtgt gacgactgtg accttgattt cccttgttgg ggaaacagct   44100
atggccggtg cggttggagc tggtggtatc ggtaacgtag ccatcgctta tggatttaac   44160
cgctacaatc acgatgtgac catcttggca accattatta tcattttgat tatctttgca   44220
atccaattct tgggagattt cttgactaag aaattgagcc ataaataaaa aagagccgcg   44280
tggctctttt taactgatca gattttctgg gcaaattttt tactcaaggc ttgtccaatc   44340
aaggcaccca ctagggctcc gatgacaata cttgcgataa atagaaggac agttccaggg   44400
tttggagcga ccatgatacg gtcgatatat tcttgggatt ttcctcttgc cagaagagta   44460
gccatatagg ctttgggcgc aatccacata agcaagattg gtcctgttgt actaaaggcg   44520
aaaataatga aagaaaggaa gttctttgtt ttgtccttgt attttcctaa atgagctact   44580
ccatctgcta ggaggccaca gataattcca ggaaggaagg aaccagcacc gtgtttagtt   44640
cccaagaaaa agagggcaat gacaaggccg atagtggtaa tggctccaaa gcgcggaact   44700
tttgcgacta ggatcatata gacgctaccg ccgacaaggg cagtaaaggc aggcgcataa   44760
aacatgtttc cagtttggtc aaagagattg cccaaaagga caccaatccc catgcagagg   44820
aagtaaagaa ctgcaaaaag cagtgtagtt aagatagatt tcttcatgaa ttgtctcctg   44880
ataatttttt cacaattctc attttatcat ggtttggtgg gattgtaaat ggatactaga   44940
agtttttgaa aacgcttgaa atatgatata atggtttcat agttattttt aggggaatat   45000
catgggtaga tttttagact ttgtctttaa tcgtttcttt ttagggatga ttgcgacagc   45060
cttcttttgg ctattaactt tagcaggagg gattatcctt ggtctagcgc cggctagtgc   45120
caccttgatg agcttatatg cagaacatgg ttatagcttt cgggaataca gtttgaagga   45180
ggcttggtct ctttacaagc aaaattttgt ctcaagcaac ctgattttct atagcttttt   45240
aggtgtgggt ctagttttga cctatggttt gtatctcttg gtgcaattgc ctcatcagac   45300
cattgttcat ttgattgcga cccttttgaa tgtcctagta gttgccctga tctttttggc   45360
ttatacagta tctttaaaat tacaagttta ttttgccttg tcctatcgaa atagtctcaa   45420
attatccttg attggcatct ttatgagtct agcagctgtg gctaaggttc tccttgggac   45480
tgtgctactt gtagcaattg gttattatat gcctgccctg ctattttttg taggaattgg   45540
gatgtggcat ttctttatca gtgatatgtt ggaacctgtc tatgaaatca tccatgaaaa   45600
attggcgaca aaatagaatg aagcagtttt ggctacatac gcttctaaga acctatagtt   45660
cagtgatgat cattatcatt gcgagttttg caatcttact ctcttacgct gactgggatt   45720
cacgtgaaaa ggaagcccag agagtagccc agcgtgtaac tgctagaaca gtgagtgaaa   45780
ttgaatatta ccatagagag tcaacccaga tagctcaggc tttagttgaa aatcaagctc   45840
gtatcgaggg aatctataaa tactttagcc ttagcatgcc agactatttt tactggcaat   45900
tagagcggaa agcttcgcct tatatatcag tctctctgta tgaaaatgtt gatgacctct   45960
atgttcgaaa tgattttgta actggggtgg ccattgcttt tcaagattac aaggaagtct   46020
atgtttctac taaagacaaa cgtagtggag aaaaaatcag ggctgaggat ttcaaaccag   46080
caggaaatag ttttgccatt ccagtgtcag atccagtgtc agatcaagac ttaggagtga   46140
tttacatctc cttggatcct gctgttttat accatgccat tgataatact agaggtcata   46200
ctccgatggc agtaacagtg acctcacctt ttgatacgga gatttttcat atgggtgaga   46260
cagttgataa ggagagtgaa aattggctag ttggcttaac ttctcatgga tatcaggttc   46320
aggtggcagt tcctaaaaac tttgttttac aaggaacagt gactagctct gctttgattg   46380
tgggtttgag ccttctcttt attgtcattc tttatctgac tttgaggcag acttttgcta   46440
attaccaaaa gcaggtagtg gatttagtag aatccattca agtcattgct caaggcgaag   46500
aggggcgtcg gattgacatt tccgagaaag atcaggaatt actcctaatc gcggagacga   46560
ccaatgatat gttggatcga ttggaaaaga atatccatga tatttaccag ttagagctta   46620
gtcaaaaaga tgccaatatg cgagccttgc aggcgcaaat caatcctcat tttatgtata   46680
atacgctgga gttcttgcgc atgtatgcag ttatgcagag tcaagatgag ttggcagata   46740
tcatttatga attcagtagt ctcttgcgta acaatatttc cgacgaaaga gagaccctcc   46800
tcaaacagga attagaattt tgccgtaaat acagctatct ctgcatggtt cgctatccca   46860
agtccattgc ctatggtttc aagatagatc cagagttaga gaatatgaag attcccaagt   46920
ttaccttgca accgctggta gaaaactatt tcgcgcatgg tgttgaccac aggcggacag   46980
ataatgtgat tagcatcaag gctcttaaac aggatggttt tgtggaaatt ttggtggtcg   47040
ataatggtag aggaatgtcg gctgaaaagt tggcaaatat ccgagaaaaa ttaagtcaga   47100
gatattttga acaccaagcc agctacagtg atcaaaggca gtctatcggg attgtcaatg   47160
tacacgagcg ttttgtgctc tattttggag accgctatgc cattactata gagtctgcag   47220
agcaagccgg tgttcagtat cgtattacaa ttcaagatga gtagaaaggg agaaaatgta   47280
taaagtatta ttagtagatg atgagtacat ggtgacagaa ggtctgaagc gtttgattcc   47340
ctttgataag tgggatatgg aggtcgtcgc aacagccagt catgccgatg aagctctaga   47400
atatgttcag gaaaatcctg tcgatgtcat catttccgat gtcaatatgc cagacaaaac   47460
agggcttgat atgattcggg agatgaaaga gatcttacca gatgctgcct atatcctgct   47520
ctcaggttat caggagtttg attatgtaaa aagagcaatg aaccttagtg tggtggacta   47580
tttggtcaag cctgttgata aggtagagct gggaaatctg ctggagaaga ttgcaggtca   47640
gctcggcgag agagggaaga aaagtcagac tcttagtcaa gaattagacg aggctggatt   47700
tgttagttat ttaggggata aggagaattg gtggataggt ctatccaagg aaaaacaagg   47760
ttccttcacc attccctact atgtcttggg tcaagactgg cagattttca tttctggcca   47820
ccccctagat ggtttagtcg ttacaccttt tgaagctcct tatcaagaac actttgaacg   47880
ctggaagctg aatgctgaga aaaccctctt ttacggttct gtaaatctgc agcagtctga   47940
gagtctcttt gcctattacg aaccgattta tagggttatc attcagggaa atctcaatca   48000
aatcgtagaa gagttaaatc tcttggagaa ggtagttctt gaaaatacac ctcgtgtttc   48060
gattactaaa cagcttttta tccagtttgt catggatgtt ttccatttat ttgaacatct   48120
caaagctgat gatatgacgg acattgtcaa aaccattcat gctattcaat ccttcgatga   48180
attggtttct tatatcaagg aaactctgat cagctttttc ggtcaatacc gtatgaatga   48240
aaatgtggtc agtgtgctgg aagtcattgg tcgtgattac caaaaagagc tttccctcaa   48300
ggatatcagt aaggccctct ttatcaatcc tgtctatcta gggcagttga ttaagcgtga   48360
aaccgattcg acctttgcag agttactaaa caaacaacgt attaaggctg cccagcagct   48420
cttgctttca actagtgaca gtatcgaaga tatttgttat gctgttggtt acagtaacct   48480
tggatatttc tataaagttt tccgaaaatt gtgcggaaaa tcgccaaaag cctaccgaaa   48540
acaggtagaa actatactat aagatttgta ttcctttaca aaaggtgcta taatattatc   48600
aggaggtcct atcatgaaaa agaaaccaat ttatctatgg gttttgctaa tcttgtctgc   48660
ccttatttca gttccgtctc tgtttggaat tgtgagtccc ttgcctagta aagaagccct   48720
tcgtgctgct cagaaacaag ttgcaggggt caatgctcag caattagaag accagcttaa   48780
ttatacctat agagtagcag aagcatctca ttctattttt aatgttgctt tgattgtgct   48840
atctactatt ttagtggtcg tagcgattgt cttccttgtt cgtaaaaatt tgcaatatgc   48900
aaactatact tacgttggct atgttttgtt agctattatt ggttcgattt atggctatgt   48960
tggtttacaa gacgctgtgc agttggttca agatgagagc atgcgtttga cagtgagtat   49020
tggttcaaaa gctgttagca ttttctatat cgtcatcaat gttctcttcc tagcccttgt   49080
cttctataag atgtggcgac aacagaaagc cttggcagaa gaagaggaaa cagaagagct   49140
tacctaagta ttgacaaaaa agaactatca agatacaatc ttggtagttg ttttttgatt   49200
atagataaaa tcatggaggt acatatgaag acaatttctt tagtttatat tagtttgagt   49260
ggcaacactg aaagttttgt gacgcgcttg aaagactatc tcttgtccca gtacaaaggg   49320
attgaggttc aaaagattca tatcaaggat ttggtcaagg aaggcaaaaa tttctatgaa   49380
atggaccatc cctatgtcgc ttttttgccg acctatctcg aaggtgggaa tggcgtggat   49440
aacggagatg ttgagatttt gacgacaccg gtgggagatt ttattgccta tggtaacaat   49500
gctagtaagt gttttggtgt ggttgggtca ggaaatcgta actttaataa ccaatactgc   49560
ctaacagcca agcaatacag tcaacgcttt ggcttccctg tattggctga ctttgaaatg   49620
cgaggcatgc tggaagatat caaacatgtc gcagctatta tcgcagattt gtatgagttg   49680
gaaaaggaga attaatactc aatgaaaatc aaagagcaaa ctaggaagct agtcgcaggt   49740
tgctcaaagc acagctttga ggttgcagat agagctgacg tggtttgaag agattctcga   49800
atagtataaa gttcttataa gaggtggttg aagttgttca actgtttttt gagtataaac   49860
agtctttaag aacgtaaaaa agcataagtt caggtcttca aaaccttgtt cttatgcttt   49920
ttatcataga aatatttgct gaattttctc ttgaaatgaa accttatctt catctcgcgc   49980
ttgtccctta ccctgctttt ccgattgcga gtgcgtagat aaagaagatg gcgaagccaa   50040
agaggaaaat caatcccgca atggcaaggt gtttgagcca agaaggaaga tttttgtttt   50100
cacgcgttac caaggcgtaa ttcaaaagag caaagaaagg tgttgtcagg aaagagccaa   50160
tcatggcaaa gcggagcatg gttgaaacct gaccagcgaa gaacttgata atgacgatac   50220
cgatgatagc agtgatggtc atccagatgt tcaaagattt acgattgtcc tctttttgac   50280
tgattagcag tcggagagat tcctgattaa cgcgagaata gccatcgata acagttataa   50340
ctgttccaaa gatacagagg aaggcaataa aggtaatcaa gtaacgggac cattcgccaa   50400
gaacagaggc atacatgccc acgaattgag agatgtattt ggctgaagca gcttcaaccg   50460
cctgccctgt aggatactga atcagtgctc ccagtgccac aaagaagacg gctaggatag   50520
ctgttccaat ataaccagtg ttaaagtcaa acagagcgtc ttctgtgtta aagttgacgg   50580
tctttctctt ttcagctgac caaagtgaat tgatggctga aatttcaata ggagccggca   50640
tccatcctag gagggagacg atgaagggca gagctgccat ttgccaaggt gtcttctcga   50700
caaaatcaga actgtattct ggatgcttga ccgccgcaat gataactgca agaacagtcg   50760
caatggttaa ggcagacata atccatttga ccatgccgtc taaaagtttg tagcctccaa   50820
agagtagcat agcccaaatg attgcaacga gaatgaggga ccactgagta atgctaagtc   50880
caatcattgg gaaggcactg gcgatgatag ctgagcacag aatggcaaca ccagccgtgt   50940
tgaccatagc cgaaaagaca ttgaggataa agaaaatcca gagatagagt tttccttttt   51000
cggcataacc ttcaaccaaa gtctttccag tatcagctgt gtattcagca ccaaaacgga   51060
aaaatggata tttaaagaca ttggctaaga tgaccaagag aagtagagac caaccgtaag   51120
aaccgccagc ttgagttgag gatacaatgt gggaacctcc aacagcggca gttgccatta   51180
ggattccagg tcccattgct tttagcttgc ttgcccaggt tgattgattt aaggaaatag   51240
cttgcgacat gataaatact cctttttgaa ttttcagaat aatctgtata tgtaatctat   51300
attctacaaa aaattttgga aaaatgcaag aatattttga aaaaagatag aaaatttaca   51360
aagaaaatct gaaataactg ttatgatata gcagattgaa actagaatag tacacctttg   51420
cttctaaaac attgttagaa atcgatttga ctgtcctgat cgatttatcc tgttcttatt   51480
tcatttcact atagtaaggt gcagcaggat aaagaaaaac cgagaagttt ctttctcgga   51540
tttgcttatt atgaggttcc tattttctat gctccaagag ttgattgatg tgatctactt   51600
ttttagcctc tcttttatag agaatagccc agatgatgag atagacaatc gcaaactcga   51660
taatgagctg gaggtagaaa atccagtgga aagggaacca accagcaaga gttgctagtg   51720
ggacaaagcc agccagcata aggaagaaat gagtcagagt ggcacgaagc atgctccagt   51780
cacggctaaa taagcggttg ccaaagttga agagcatacc gatggttgcc cagataagtg   51840
tgcagtagag caagaccagg gcaccgtgaa cctgatgctg atccatcact tggcctatga   51900
gagagtaggg atttagtggt gcgtaggtat ttggtgcata aatgagtgaa aagaggatag   51960
agaggatgag gccgataaga acaccggtag ctgcatcgtg aaatacttgt tttttcatag   52020
ttctaatttc tccttgatgg tttttagata acggcgtgaa gagtaggtga agctttcgtt   52080
tttcaagaaa atttctacca gaccgtttgg cgtgagcttg aggtgagaga tggaatcgat   52140
attgatgatt tctgattggg aaatttggat aaaattggtt ggcaagagtt taagaacctg   52200
atagagtcgc aaatcaatgc tgtaggtctg actcgcggtt tctgctagaa ccttccgatt   52260
ctcgatatag aagcgctgaa tcttgccaat ctcaactaga tagacctgat catcgatttt   52320
tcctttgatt ttttctcttt ggtccagatt ttctgcgaac tcgatgactt tctggacttt   52380
ttcggtttct tgaggtgctt ggacaatcag cttttcctcc tcgtaagtct cactaatctg   52440
tagttctact ttcatagttt tctctccttt tcagttatac aaggttgtga tcacttcctg   52500
tatatcctta ttaaacacta ttttatagcc catggcaagg aaccttgtct atgtggaggg   52560
attgggctcc tatgtggtgg agcttttctg ttctttctga aatatggtat aatagcacta   52620
atcaatttct aggaaaatag atacggaaag gggctgaaag aactagggga acagttggaa   52680
ttagaaagtg ataggtatga aaagtggcgt tgaagctgaa taagtttata aagcgtttga   52740
atgaagaaat ggaaagtaaa taagttgacg atgaattaca aaatagattt tatctacaat   52800
ttgtatcttt caaatcattg atttgaattt tagatttaat catgttacaa ttaaaactga   52860
aatcaaatag aagaggaaaa tgcaaacgtg ggcacactat tagcaacaag attaaaaaat   52920
agacggaaag aattaaaaat gtctcagcga gaactagctg aaggtatctg taaacagggg   52980
caaatcagtc gattagagag cggagagttt acccctggag cggatttcct gaatgccctt   53040
gctaagaagt taaaagtcag tatggattat ttttttgatg agcaggttgt agagaaagtt   53100
gaggagttat cagaatttaa gaaattagca cagacattta ttacaaatcg caattatgag   53160
tctttgaaat atatatatga attggagaat gtaaaagctc accgcctatc tttagcagat   53220
aaaatctaca tggaatggat aaaatctctg atagattttt atttttacgg acagaaagaa   53280
gatgcgattg tacgattaga gggggtatta tcacagttaa gtgtatctga tttgaactat   53340
ctccaagttt caaacaccct attcaatttt tattatgata ttggagattt aggtcgtttc   53400
aataaaattc gtgaaaaact agagtatcaa gtaaatcacc tcaatttgag tacaatcgaa   53460
gagttagaac tatctattaa gtttaactac aacgtttgtc gttatctatg gttacagaaa   53520
aatattgaag aagctattac taaaattaca gctactataa aacaatgtaa ggcttacaga   53580
acgaattatc ttttggctga tttgtactta ttgatgggaa atgtaagtga aaatttttct   53640
tctaaaagtt cggtgaaaga atattttgag acggcatatt ttctatacaa acttgaggag   53700
aacatgtcaa tgactctgaa agttgagcat tacattgcag atataacaga ataatgaata   53760
cggtgttcaa gtgagcatcg tttttcaaac ctagttcaga tacaaaaaag tatcaaacaa   53820
aaaaaaataa aaaaacatta taaaaacaat tgacaagcta attttgaagt gataaaataa   53880
atgcaagaaa acaaaaggag aggtatatga gaagtttgtt taagaaaata gttgctgtat   53940
tagttattgg cttaattctg ttaggaattg cgagaacacc tcaagttcat aagatggcta   54000
gagggattga tcctggtcct gcgaatttta tttagaaatc aatttctact aattgagtat   54060
taatgggtaa aaagattgta tggataagaa aaatttactt gtattggtta ctggttcggt   54120
aggtgccagt aatgtagata catacttata ttacataaaa aaattctata atgttaaagt   54180
gatactttct gaaaattcta aaaaatttat aagtaaggaa ttaattagtt atttttgtga   54240
taaagtttat gatgaaatat ttgttgaaga ggtagttccg cacgtttttc tgccatatga   54300
atctgactta cttcttattt taccagctac ggcaaatgtg attggcaaaa ttgctaatgg   54360
tattgctgat gatttagtta cagcaactgt tttaaacttt aataaaaaaa taattttttg   54420
tcccaatatg aactctacta tgtgggacaa tcacatagtt caaagaaatg tatcaattct   54480
aaaggagttg ggacatatat ttttatttga gtctaaaaaa acatatgagg taggattgcg   54540
taaagcaata gattcaacat gttcaatgtt acaaccacag tcgttagtaa aagaacttat   54600
caaattagaa aatattgtcc ttgaagaggg acattaaaaa ctactgagaa tattaatgag   54660
gggaaaaaat ggaaaattca tcaatcgatg tagatatgct gttggaagaa ttgacacaag   54720
aagcaatggt cgttgttgct gttgataagg actgttaatt taaacttatg gcaatatatg   54780
aaaggttact ggatgtttta aattatgcag gcagtagcct tttattatat acaaatggat   54840
aaagtaagga taatacaatg attaataaaa aaatacaaca agttgttttg gaatcattac   54900
agaatttttt gaatgggaac ttcatttcgc cttgtgtagt ctatgatttt ggcttgctgg   54960
aaactgtact tgatgaattt aaaaatcaaa ttcctgtaac attcaattac caactttttt   55020
atgccgttaa agcaaattca aatgagaaga tacttgaatt cttagtagat aaaattgatg   55080
gagttgatgt ggcgtcatta tctgaattag atgtggctaa aaaatttttc ccaccaactc   55140
aaatttctgt taatggtccc gcattttctt atgaaacttt atataatctg attaaaaaac   55200
aatataaagt tgatattaac tttttggaac atcttcaaca attttcccca aaagaatctg   55260
ttggaataag agtaacggag ccagatgaac ttaataatcg tatgagtcga tttggaataa   55320
atatttgcag tgataattgg actagtaatt tacaaaatcc tttaattaca cgactgcatt   55380
ttcattttgg agaaaaagat gataaattta ttgttaagtt agataaaata ttatttaagt   55440
tacaagaaat taataaactt agagaggtta gagaaataaa tcttggaggc ggttttatga   55500
aattatttat ggaaaatcgt ttgaaagaat tttttctatc acttatggaa atctataaaa   55560
agtacgatat tgatagtact gtgactacaa taatagaacc aggtagtgca attacttcat   55620
tttctgccta tatgattact agcccagtta atgttagtga ggtgaatgag cagcaggtta   55680
tcacgttaga cacatcaata tacaccaata cattatggtt tgttccgcat attattacaa   55740
cgttaaattc aagtagtaaa gagcgttata gtactattct ctatggtaat acctgttatg   55800
aacatgacaa gtataaaatg aaagtttcgc ttccaaggtt aactcaaaat agcagtatag   55860
tgttttttcc tgtaggagct tatataaaaa gcaatcattc aaatttacat cgtaatgatt   55920
ttatgcggga ggtatatttg tggacaaaaa acttgacata ttagataaag ttaaggaata   55980
tttaggaaat aaaactactc aaattctgga taatcaatat aaagaatttt tgaaacttaa   56040
tgatataagg cgagcgtttg gtatttcaga aaaagtatta aacaattctt ttaattttac   56100
gagtaaagaa tttaatgatt taattaataa cgaaaattat ttattcgaat atgcatgtag   56160
aattagagag gaatggagaa aaaaatgctt taatcattct tatcgttttc tatgctcacc   56220
tataattaca gatgattttc ttaacacgaa gacattgaga agtagccaaa ttgaatataa   56280
atatgagcga tatttatcga aaagttcgat aggcgataga gcggttgatg gctttgtttc   56340
cttcaatact ttaacagcta atggtatgtc tgctattaaa ctatgtcttg agatattaaa   56400
ctctattttc ttcaagaaga agattgattt attatattca accggatatt atgaaacaag   56460
atttttatta aataatcttg ctaaatcagg tattagttgc tatgaggtaa gtaattgtga   56520
attggataaa gataaatttt ataatgtatt catgatggaa cccaatcgag ccgatttaac   56580
attacaaaaa actgatttca agatagtaga atattttgtt aagtataaaa ataattcaat   56640
aaaagtcgtt attttagata tttcatatca aggttctaat tttaaattag tagaattttt   56700
agagaaattt aaatttgcga atgtaattat ttttgtggta cgatctttga taaaattaga   56760
tcaaatggga ttagaattga caaatggggg aataatagaa gtgtttattc ctaatcattt   56820
gagaaagttg aaaaatttta ttgaagagga attcaataaa tttagaaatt ctcacggagc   56880
taatctaagc ctctatgaat actgtttgct tgataattct ttaactttaa aaaatgattg   56940
gaactattct gatttagtta tgaaatttac gagtaatttt tatgctgata taaaagactt   57000
gttcatggaa aattctgata ttgaaatcat ccatgaagag ggagtacctt ttgtattttt   57060
agatttaata ggtgaaggta aaaaagaata tgaaatgttt tttcaatggt taaacttctt   57120
ttacaaacag cttggaatca cattgtatgc tagaaatagt tttgggtttc ggaatctaac   57180
agtagagtat tttggaatta ttgggacaga aagatatata tttaagattt gtccaggtgt   57240
ttataaaggg ttaagttatt atttgatgaa atttttatta aaatcttttt caaatgaata   57300
tttaaaaact actgatgagg ttaatagatg aaaaatttga taaagttgct aataattaga   57360
ttgattgtta acttagcaga cagtgtattt tatatagtag cattgtggca cgttagcaat   57420
aattattctt cgagcatgtt cttaggaata tttattgcag taaattatct accggatttg   57480
ttactaatct tttttggacc agttattgac agagtaaatc cgcaaaaaat tcttataata   57540
tcaattttgg ttcaattagc agtggctgta atatttttat tattattaaa ccaaatatca   57600
ttttgggtga taatgagtct agtgtttatt tcagtaatgg ctagctccat aagttacgtg   57660
atagaagatg tgttgattcc tcaagtggta gaatatgata agattgtatt tgcaaattct   57720
ctttttagta tttcgtataa agtattagat tctattttta attcattcgc atcattttta   57780
caggtggcag taggatttat tttattggtt aagatagata taggcatatt tttacttgct   57840
ctatttatat tgttgttgtt aaaatttaga actagcaatg cgaatataga aaacttctct   57900
ttcaaatatt acaagagaga agtgttgcaa ggtacaaagt ttattttaaa taataaatta   57960
ttatttaaaa ccagtatttc tttaacgctt ataaactttt tttattcatt tcagacagta   58020
gttgtaccga ttttttctat tcgatatttt gatggtccga ttttttatgg tattttttta   58080
actattgctg gtttgggtgg tatattggga aatatgctag cgccaatcgt aataaaatat   58140
ttaaaatcga atcaaattgt tggtgtattt ctttttttga acggctcaag ttggttagta   58200
gcaattgtta taaaagacta tactttatca cttattttat ttttcgtttg ttttatgtct   58260
aaaggagtct tcaatattat ttttaattcg ttgtaccaac aaatacctcc acatcaactt   58320
cttggtaggg taaatactac cattgattct attatttctt ttggaatgcc aattggtagt   58380
ttagttgcag gaacgcttat tgatttgaat attgaattag tgttaattgc tattagcata   58440
ccttattttt tgttttctta tattttttat acggataatg gattgaaaga atttagtata   58500
tattagaaat gtttatgttc attcaaaagc ataatgacta taactgaaaa agaaaagtga   58560
tatctttaag gttgttcttc ttggtggtga gattcgtgag acaacccaag cttttgtcgg   58620
aaagattacc aatgctttga tggataggat gtactttagc aagatgtttt tagtggtaac   58680
ggtatcgtgg atggacgtgt aataacctct tctttcgagg agtattttac taaaaaacta   58740
gccttggagc gttccccaga aacggactta ctcattgact cttcaaagat ttggggagaa   58800
gattttgctt catctgttcc ttgaaaaaag tcacagcagt catcacagac gatagtactg   58860
aacaaaacta tgaagagtta gaaatttata cgcaggtgat tgtataaagg atctggaaat   58920
agataagaag ttgattagta ttgacctagg tggtacaaat attaagatta ctgttctttc   58980
aaatgacggt gagattgaaa ctttgtggag tattacaaca gatacaagtg agaaaggttc   59040
tcaaattata tcggacatca tcagttctat taaaaataaa ttgaccgaac ggaatattcc   59100
tgatagcgac cttcttggaa tcggtatggg aagttgctca tcatactttc cttgtaaatc   59160
ataggggcta taaactctcc gtctacttgt cctgcaacaa ttgaagtctg ctcaaaacgc   59220
cgtccgctaa tcttttcata gactttctcc cttttaggag cctagctttc tagtttgttc   59280
tttgattttt attgagtata ccactatttt actccctctg gcaagggact ttgtctatgt   59340
ggagggattg ggctcctatg tggtggagct tttctgttct ttctgaaata tggtataata   59400
gcactaatca atttctagga aaatagatac agaaaggggc tgaaagatgt ctcatattat   59460
tgaattgcca gagatgctgg caaaccaaat cgcggctgga gaggtcattg aacgtcctgc   59520
cagtgtggtc aaagagttgg tagaaaatgc cattgacgcg ggctctagtc agattatcat   59580
tgagattgag gaagctggtc tcaagaaggt tcaaatcacg gataacggtc atggaattgc   59640
ccacgatgag gtggagttgg ccctgcgtcg ccatgcgacc agtaagataa aaaatcaagc   59700
agatctcttt cggattcgga cgcttggttt tcgtggtgaa gccttgcctt ctattgcgtc   59760
tgttagtgtc ttgactctgt taacggcggt ggatggtgct agtcatggaa ccaagttagt   59820
cgcgcgtggg ggtgaagttg aggaagtcat cccagcgact agtcctgtgg gaaccaaggt   59880
ttgtgtggag gatctctttt tcaacacgcc tgcccgtctc aagtatatga agagccagca   59940
agcggagttg tctcatatca ttgatattgt caaccgtctg ggcttggccc atcctgagat   60000
ttcttttagc ttgattagtg atggcaagga aatgacgcgg acagcaggga ctggtcaatt   60060
gcgccaagca atcgcaggga tttacggttt ggtcagtgcc aagaagatga ttgaaattga   60120
gaactctgac ctagatttcg aaatttcagg ttttgtgtcc ttgcctgagt tgactcgggc   60180
taaccgcaat tatatcagcc tcttcatcaa tggccgttat attaagaact tcctgctcaa   60240
tcgtgctatt ttggatggtt ttggaagcaa gcttatggtt ggacgttttc cactggctgt   60300
cattcacatc catatcgacc cttatctagc ggatgtcaat gtgcatccaa ctaagcaaga   60360
ggtgcggatt tccaaggaaa aagaactgat gactctggtt tcagaagcta ttgcaaatag   60420
tctcaaggaa caaaccttga ttccagatgc cttggaaaat cttgccaaat cgaccgtgcg   60480
caatcgtgag aaggtggagc aaactattct cccactcaaa gaaaatacgc tctactatga   60540
gaaaactgag ccgtcaagac ctagtcaaac tgaagtagct gattatcagg tagaattgac   60600
tgatgaaggg caggatttga ccctgtttgc caaggaaacc ttggaccgat tgaccaagcc   60660
agcaaaactg cattttgcag agagaaagcc tgctaactac gaccagctag accatccaga   60720
gttagatctt gctagcatcg ataaggctta tgacaaactg gagcgagaag aagcatccag   60780
cttcccagag ttggagtttt tcggacaaat gcacgggact tatctctttg cccaagggcg   60840
agatggactt tacatcatag atcagcacgc tgctcaggaa cgggtcaagt acgaggagta   60900
ccgtgaaagc attggcaatg ttgaccaaag ccagcagcaa ctcctagtgc cctatatctt   60960
tgaatttcct gcggatgatg ccctgcgtct caaggaaaga atgcctctct tagaggaagt   61020
gggcgtcttt ctagcagagt acggagaaaa tcaatttatt ctacgtgaac atcctatttg   61080
gatggcagaa gaagagattg aatcaggcat ctatgagatg tgcgacatgc tccttttgac   61140
caaggaagtt tctatcaaga aataccgagc agagctggct atcatgatgt cttgcaagcg   61200
atctatcaag gccaatcatc gtattgatga tcattcagct agacaactcc tctatcagct   61260
ttctcaatgt gacaatccct ataactgtcc tcacggacgt cctgttttgg tgcattttac   61320
caagtcggat atggaaaaga tgttccgacg tattcaggaa aatcacacca gtctccgtga   61380
gttggggaaa tattaaaagt ataaaaaagt ctgggaaaaa ttttcaaaat caaaaaaacg   61440
cataaaatca ggtgttcaaa aaccttgatt ttatgcgttt tatcatggaa atagttactt   61500
cattttttcc taattctttt cgaaactctt tttaaacgac gtcagtttta tcagtaatct   61560
caaaacagtg ttttgagcta attttgccag ttttgtctgt aacatcgaag ttgtgtttta   61620
ccactctgcg actggtttcc tagtttgctc tatgattttc acagagcatt aaattgcgat   61680
tttgccaagt ttctttattc gtctaaaagt agagtctgtt ctatgcgtct aatgtacgaa   61740
tcaggttgac catttcaata gctccttgtg cacactcaga acccttattt cctgctttag   61800
taccagctcg ttctatggct tgttcaattg tatctgtcgt tagcacacca aacataacag   61860
gaatttcgct atttaaactg atttgggcga ttcccttaga tacctcgcta catacataat   61920
cataatgact tgtattccct ctaatgacag ctcccaagca gataattgca tcatattttt   61980
tactttttgc catttttgat gcaatcagtg gtatttcaaa agctcctgga acccaggcta   62040
cctctatatc tttctcgttt acattctctc ttttgagatt atctagtgct ccagataata   62100
attttgaagt tataaattca ttaaatctcg ctacaacaat acctatttta atattgtttg   62160
ctactaaatt accttcataa gtgttcattt atttttcctc catatttaaa atgtgaccca   62220
ttcgattttt ctttgtttct aaataaaaac tatcgtaagg attggcttct atttcgattg   62280
atattctact ggaaatggta attccatatt tttctaactg ttcaaccttg tcaggattat   62340
ttgtcagtaa atgaagtgac tgaagtccca gatctttaag catttttgct ccaatatgat   62400
attctcttaa atcaccttca aagcctaatg caagattggc atcaagcgta tccatgcctt   62460
gatcttgtaa atgataggct tttaatttat tgataagtcc aattcctcgt ccctcctgtc   62520
gcaagtaaag taagacaccc gaaccattct caacaatcat tttcatagcc ttatcgaatt   62580
gctgtccaca atcgcaacgt aaagagccta aaacatctcc tgttaaacat tcggagtgga   62640
cccgacataa tacattggct tcatcctcta tatttcccat aataagagca agatgatgtt   62700
ccccatttag tttatctata tagctaattg ctttgaaatt accgtatcta gtaggcatat   62760
tgacagttga aactcgttct accagctgat catatacttt tctatattct tgtaattctt   62820
tgatggtaat tagtggaatg ttgtgttttt tcgagaactg aattaaatca tctgttctca   62880
tcattttgcc atcatgattc attatttcac aacataggcc acactctttt agtccagcta   62940
attttaataa atcaacagtt gcttctgtgt gtccatttct ttctaggaca ccaccttttt   63000
ttgcaattaa aggaaacatg tgtcctggcc tgcgaaaatc agagggtgtt atatcttcag   63060
ctacacacat acgtgcggtc agtcctcttt cctcggcaga aatacctgtg gtcgtttctt   63120
tataatcaat tgaaactgta aaagcagtct tatgattatc tgtattgttt tcaaccatag   63180
gtgaaagcat taattgatta gctaaacttt cgctcatagg catacaaatt aatcctttgg   63240
cataagtagc cataaaatta acattttctg ttgtagctgc ttgtgcagaa caaattaagt   63300
ctccttcatt ttctctatcc ttgtcgtcta taacaagaac aagtcgtccc ttctgcaatg   63360
cttctaatgc ttcttgtatt tttcgatatt ccattgactg attatccttt ctgctaaaat   63420
ccattttgat ataatagttc cttagatatt tctgattttg gagagttatc catcagtttt   63480
tgcacatatt tacctaagat atcattttca agatttactg tactcccgac ttgtttactc   63540
ttaagaatgg tttgttccaa ggtatgaggg ataacagata ctgaaaagtt tactttggag   63600
actttagcga cagtcagact aatgccgtca attgtaatag atcctttttc aactattaaa   63660
tctaaaattt ctttttgtgt gttgatttga taccatacag cattatcatc tttttttatt   63720
gacgagattt ttcctgtacc atcaatgtgt cctgtaacga cgtgaccccc aagtcgaccg   63780
ttgacagata aggctctttc tagattcacc tcacttccat gttttaatag agtaagagct   63840
gttcgactcc atgtttcatt cattacatca actgtaaagg attgatgatt gaaatgagta   63900
actgtaagac agataccatt tactgctata ctatcgccta aatggatatc cgttaatatt   63960
tttgaggctt taattgatag tttacaatta cgagagtctt tctgtattct ttcaactttt   64020
ccgatttctt caattattcc tgtgaacatg gataaatcac ttcactttct atgagatagt   64080
catttcctat ttgagaaaat gcataaggtt tcaatctaat agcgtcattt ggcaaagaaa   64140
taccttcacc tccgacagga aacttggcac tacctccaaa aacttttggt gcaatatata   64200
ttttcagctc atcaacaatt tgttgttcca aagcactcca attcattaga ctgccccctt   64260
ctagaactag gctatcaatc tgcatgtttc ctagatgttg cattaaactc gataagtcta   64320
tatgattgcc ttttttcttt atggaaagta tttcacagcc atgattttga tatagcttca   64380
ttttattttt gtcttcagag gaagtggcaa tgtaagtttt aatatcattt gctgttttta   64440
cgattttaga ggtaagagga gttcgtaaat gtgtatcgca tatgatacgg ataggatttt   64500
tcccttcctc caatctacat gtcagcaaag gatcgtcttg aataacagta ttgactccca   64560
ccataattgc actaacatgg tgtcgtaact gatgcacatg ctttcttgct tcttcttcag   64620
taatccattt ggattgattt gttttagtgg ctatttttcc atccattgac attgcatatt   64680
tcataaaaac atagggtaca tgctgggtaa tatactttct aaaacttttt attaagttaa   64740
gacactcatt ttctaaaatt ccaacagtaa cttgaagatt attttcctca agtatcttta   64800
ctccttttcc agatacaata ggattacagt ctaggcttcc aatgactact cttgtaatac   64860
cactatcgat tatagcatct atacagggag gtgttttccc gaagtgacaa cagggttcaa   64920
gtgttacata aagcgtcgct ccgacagggg attctctaca gtttttaaga gcatttctct   64980
cagcatgtgg gccaccaaaa aactcatgat aaccttgtcc gataatgtga ttatctttta   65040
caataactgc gccgaccata ggattgggat tgacgtaacc agcccctttt tgtgccagtt   65100
ttattgctaa tttcatatat tttgaatcgc tcatctcgct acctccaaaa aaatatacct   65160
tgaatagggg actactcaag gcatacaaaa gaaaacttat gcgattaaca aaaatgctct   65220
gaaatgacaa gtaatcattt cagagcacgc aaaaagcaca aatatacttt tatcttcttt   65280
catccagact atactgtcgg ctttggaatt tcaccaaatc atgcctttcg gctcgtgggc   65340
tataccaccg gtagggaatt tcaccctgcc ctgaagatag ttattcaatt acagatgatt   65400
atagtactta attttgaata tgtcaacaga taaataccga ttgtttttga tatactgtat   65460
ttgtgataat cgattctcgc tcctcggata aagaaaatat gatatactag ataaacgaaa   65520
taagagagaa ggaatactat gtacgcatat ttaaaaggaa tcattaccaa aattactgcc   65580
aaatacattg ttcttgaaac caatggtatt ggttatatcc tgcatgtggc caatccttat   65640
gcctattcag gtcaggttaa tcaggaggct cagatttatg tgcatcaggt tgtgcgtgag   65700
gacgcccatt tgctttatgg atttcgctca gaggatgaga aaaagctctt tcttagtctg   65760
atttcggtct ctgggattgg tcctgtatca gctcttgcta ttatcgctgc tgatgacaat   65820
gctggcttgg ttcaagccat tgaaaccaag aacatcacct acttgaccaa gttccctaaa   65880
attggcaaga aaacagccca gcagatggtg ctggacttgg aaggcaaggt agtagttgca   65940
ggagatgacc ttcctgccaa ggtcgcagtg caagcaagtg ctgaaaacca agaattggaa   66000
gaagctatgg aagccatgtt ggctctgggc tacaaggcaa cagagctcaa gaaaatcaag   66060
aaattctttg aaggaacgac agatacagct gagaactata tcaagtcggc ccttaaaatg   66120
ttggtcaaat aggagcagag aatgacaaaa cgttgttcgt gggtcaagat gaccaacccg   66180
ctctacatcg cctatcatga tgaggagtgg ggccagcccc tccatgatga ccaagtattg   66240
tttgagttgt tgtgtatgga aacctatcag gcaggcctgt cttgggaaac ggtactcaac   66300
aaacgccaag ctttccgaga agtctttcat agctatcaaa ttcactcagt cgcagagatg   66360
actgacactg aattggaagc catgctggag aatccagcta tcattcgaaa tagagccaag   66420
ctttttgcta cacgcgctaa cgcccaagcc tttctacagt tacaggcaga gtacggctct   66480
tttgatgcct atctttggtc ttttgttgag gggaaaactg tcgttaacga tgttcctgat   66540
tatcgccaag cgccagctaa aacaccctta tctgagaaat tagccaaaga tctcaaaaaa   66600
cgaggcttca agttcacagg cccagtcgcc gtattgtctt ttctacaggc tgcagggcta   66660
gttgatgacc acgagaatga ttgtgagtgg aaaggtctta aatgatgtct aacaaaaata   66720
aggaaattct gatttttgcg attctctata cagtcctctt tatgtttgat ggcgttaaat   66780
tgctggcttc tttaatgcca tctgccattg caaattatct tgtttatgta gttttagctc   66840
tatatggctc cttcttgttc aaggatagat tgatccaaca atggaaggag attagaaaga   66900
ctaaaagaaa attcttcttt ggagtcttaa caggatggct ctttctcatt ctgatgactg   66960
ttgtctttga atttgtatca gagatgttga agcagtttgt gggactagat ggacaaggtc   67020
taaatcagtc taatattcaa agtacctttc aagaacaacc actactgata gctgtttttg   67080
cttgtgtcat tggacctctg gtagaagaat tatttttccg tcaggtctta ttgcattact   67140
tgcaggaacg gttgtcaggt ttactaagca ttattctggt aggacttgtt tttgctctga   67200
ctcatatgca cagtttggct ctatcagagt ggattggtgc agttggttac ttaggtggag   67260
gccttgcctt ttctattatt tatgtgaaag aaaaagagaa tatctactat cccctacttg   67320
ttcacatgtt aagcaacagc ctctccttaa tcattttagc tatcagtata gtaaaatgaa   67380
atgagaacag gacaaatcga tttctaacaa tgttttagaa gtagaggtgt actattctag   67440
tttcaatata ctgtaatatg tgatgaaaat gccagtaatg ataccgagaa aaaagctgag   67500
aaacttttcc cagctttatt tgttatagtc aaagagaatg acttgttcct gtgcatctac   67560
atgagcatgg accccaaagg gtacaattgc tcttggagtt gcgtggccga cattcagatt   67620
atagacaatc gggatattgc tgtcaatgat atccaatagt gcctctttat agtcgtcatg   67680
gaaagtttca tccataggtt ttccgaccaa gagtccattg atgaccgcga atatgccagt   67740
gtcctttaaa gttagcaaca tctttttgaa gtcttctggc ttaggctttt cttcgcttgt   67800
ttcgagcaag aggattttcc cttcccagtc tgacaagtca gggaaaagtt tgtatttttg   67860
gcagagttcc gtgctatctg cgtatcgaga gttgtcaaag atatcgtaga gggattcgag   67920
gcaaccaccg aggattttcc cctcgaactg ggcacttcct tgcaacaagt caaaacctgt   67980
atttgtatga ctgacacgag gtgttcccag ggccgtggga ctaaaatcag ttcgttcctc   68040
ataccaaacg tcactagggc ggatttctga aattcttccc gtctcaatca attctttaaa   68100
gtagtgaagg ctataggcta gcatttcttt gtctaattca caaatgtctg ctaaaaagga   68160
ttgaccataa aaagtcttga ttcctaattt atgcaacatg aggtggttca tggttgtatc   68220
cgagaagcca agaaaaattt tttgcttgat aaccttttgg agttggtcat tttcaaaaag   68280
ataaggtagc aagcgatagg tatcgtctcc accgatggca cataggatca tgtcgatgct   68340
atcatcagaa aaggcatgaa tcaaatcctc tgcacgagct tcaggatggt ccttgataaa   68400
gtctaatcct tttaacgaat ggggcaaaaa gatgggattg agtcccagat ccttgagacg   68460
ttggataccc aagtccactt cgtgtttgac aaaatcctct ccgataatgc cactagataa   68520
actaacaata ccaatagtag aaaccatatc tcatcctcct agaaatagat tgagcctatt   68580
ttatcacaaa atataagaga aagctatgtg ggatttcaga agaatacttt taatactctt   68640
cgaaaatctc ttcaaaccac gtcagtttta tctgcaacct caaagctgtg ctttgagcaa   68700
cctgcagcta gcttcctagt ttgctctttg attttcattg aatataactc aaaaaagtaa   68760
gtgaaaaagc aaccgcacct gcagttgctt ttatcgtttt cttattcttg atagcgtgtt   68820
ggtcctgcac ttgcactacg gatattcaag cgtttcttga gatagaagcg aagggctagg   68880
agggctgctc caataatagc tagtggcaat ggatccagta ctgggttaag gctagctggt   68940
aggaagcttg ttgcaaagaa gacaagcaac caaaggaaca tagaagctag gataactagt   69000
acagatttcc agaaaggtgg acgttgactg cgatccatat ctggtccata gtattggtaa   69060
acaaagtagt acatcaagta gaaggcaaat ccaccaacca gtccaactaa tagaagagta   69120
atcaatccat agccgaaagc ttggtctgcc gcaaagaagg ttgtgagggc gctgacaagg   69180
gcaaagaggc tagtgatgaa aagagctgag tccataatca tcagttttgg gtcatcattt   69240
tcttttggat gctctttttc gtactgctct ttgacagtga agctatgagc ccaatgagtt   69300
ggtgcgccgt atagggaacg ggcagttgta cctttagatt gctcctcaag gatttgggga   69360
atgacttcct caaaaatagt ctggatttca gcgtctgttt tcccatcttt gatgaattgt   69420
tgggtagcaa tgtggacaaa ctcttggttt ttcttagtta atttttgtag atcaatttga   69480
gacataggaa ctcctcttag aaccattttt tatggatgag atagagagtg agcgagacac   69540
tcatagcaaa ggcgataaag acgattaacc agaaggcatt tggctctccg tttaggggga   69600
tttcattatc cttaaagttc atcccgtagg cagaaaagac catggttggg atggacatga   69660
cgatggtcac aagggccaag gttttcatga tgttgttctg gttgttagaa atgatagagg   69720
caaaggtctc tgtcatagaa tgcaagacgt ttccataaat atctgccatc tcgatggcct   69780
gttgggtttc aatcagggtg tcttcaagca ggtcttcgtc ctcaaggtat ttcttgatat   69840
tgctggttga actggtcaat ttcttaatca cgcgctcatt tgttttgagg gaggccttga   69900
aatagacgat agttttttcc aattccatga gctcaatcaa ttcttcatta cgagttgatt   69960
gatgcagttg actttcgatt tgttcactct tgcggtcgat tgaacgaagg gctgttaggt   70020
aaagctctgc attgcgataa agaatttgaa agataaaacg tgaacgcatg aaggtataga   70080
aattacgcaa tcgacggttg ataaagacat caaggacagg tagtggttcc aaacacgtag   70140
tgataatggt ttcctcagtg atgataatac caagcgggat ggttacgtag taggtgcggt   70200
tatttctttc ctccgtgacc ggcacgtcta cgataatcag ggtatactcg tcttcaatgg   70260
taatacgaga catttcttcc gcatcgagcg gtgctcgaag gtcagcaata tcaatatcga   70320
aggtgttggc gatttcgagt gattcatttt gagtcggatt gacgagattg atccaagtac   70380
ccggttcaag cgtatcgatc tctttaaatt cagttgttgt agagagaaaa acttgtttca   70440
tatcccttat cctttctcat ttttcagatt ttttcacact gtactattat actacaaaat   70500
cggccttttg ggtaatagaa tctcactttt tttggtataa tggtaagcaa taatggacta   70560
gaaagaacaa agatgcaaga taaaattgtc attcatgggg cgcgtgccca taatttaaaa   70620
aatattgatg tggagattcc gcgagacaag ttggttgtcg tgactggctt gtcaggttca   70680
gggaagtcca gtctggcttt tgatactctc tatgcggagg gacaacgtcg ctatgtagag   70740
agtttgtccg cctacgctcg tcagttcttg ggaaatatgg aaaaaccaga tgtagatgcc   70800
attgatggtc tcagcccagc tatttccatc gaccagaaaa cgactagtaa aaatcctcgc   70860
tcgacggtgg gaacgacgac tgaaatcaat gactatctgc gtctcctcta cgcacgtgtg   70920
gggacgcctt actgtatcaa cggacatgga gctatcaatg cttcttctgt ggagcaaatc   70980
gttgataagg ttttggagtt acctgaacgc cagcgcttgc agatcttggc tcctgtcatc   71040
cgcaagaaaa aaggccaaca taagagtgtt atcgagaagg ttcagaaaga cgggtatgtt   71100
cgtgtccgtg tggatgggga agtctatgat gtgaccgaag tgccagagtt gtctaagagc   71160
aagcaacaca atatcgatgt cgtggttgac cgtattgtta tcaaggaggg cattcgtagt   71220
cgtctctttg attccattga ggctgccctt cgtattgcag aaggttatgt cattatcgac   71280
accatggacg actcggagtt gttgttctct gagcattatg cctgtccagt ttgtggtttt   71340
actgtcccag agttagagcc tcgtctcttt tctttcaatg ctccttttgg ctcttgtagt   71400
gagtgtgacg gcttgggcat caagctggag gtggatactg atttggtagt gccagatgct   71460
agcaaaacct tacgtgaggg agcgctagca ccttggaatc ctatctcatc caactactat   71520
ccaaacatgt tagagcaggc catgaaagtc tttggagtgg ctatggataa gccttttgag   71580
gacctgtcag aagaagataa gaacttgatt ctctatgggt cagatggtaa ggaattccat   71640
ttccactatg agaatgaatt tggtggcgtg cgcgatatcg acattccgtt tgagggagtt   71700
atcaataata tcaaacgtcg ttaccatgaa accaatagcg attacactcg cactcagatg   71760
cgtctctaca tgaatgagct gacctgcgga acctgtcaag gctatcgtct caatgaccag   71820
gccttgtctg tccgtgtggg cggccagcaa gggccacata ttggagaaat ctcagacctg   71880
tctatcgctg accacttgga cttggtgagc cagttaactt tgtctgaaaa tgaagccatc   71940
attgctcgtc ccattctcaa ggaaatcaag gatcgtttga ccttccttaa taatgtgggt   72000
cttaactatc taaccctgtc acgttcagca ggaacccttt caggtgggga aagtcagcgc   72060
attcgtttgg caacccagat tggttccaac ctatcaggtg tcctctatat cctagacgag   72120
ccgtcaatcg gtcttcacca gagggacaat gatcgcctga ttgccagtct gaaaaagatg   72180
cgtgacttgg gcaatactct tatcgtggtg gaacacgacg aagataccat gcgtgaggct   72240
gattatctga ttgacgttgg tcctggtgcc ggtgtttttg gtggtgagat tgttgcagca   72300
ggtacaccta agcaagtggc tcgcaacagc aagtctatca caggtcagta cttgtcaggc   72360
aaacgtgtca tcccagtacc agaagagcgc cgtgtcggaa atggtcgttt tattgaagtg   72420
ataggagcgc gtgagaacaa cttgcaaaat gtcacggctc gctttccact aggaaaattt   72480
atcgcagtga caggtgtgtc gggttcaggg aaatcgactc taatcaacag cattctcaaa   72540
aaagccattg cccagaagct caaccgtaat tcagacaaac ctggtaagtt taagactatt   72600
acagggattg agcatgtcga ccgtttgatt gatattgacc agagccctat cggacggacg   72660
ccgaggtcta acccagctac ctatacagga gtttttgacg atatacgtga cctttttgct   72720
cagacaaatg aagccaagat tcgaggctac aagaaggggc gcttcagttt caacgtcaag   72780
ggaggtcgct gtgaagcttg ctcaggtgac gggattatca agattgagat gcacttcttg   72840
ccagatgttt atgtggcttg tgaagtttgc cacggaaccc gctataacag tgaaacccta   72900
gaagttcact acaaggaaaa gaatatttcg caggtcttgg atatgacggt caacgatgcg   72960
gtagaatttt tccaacacat tccgaaaatt caacgcaaac tccagaccat caaggatgta   73020
gggctaggct atgtgacctt gggacagcca gctaccaccc tttctggggg agaagcccaa   73080
cgtatgaagt tagctagcga actccacaaa cgatcgacag gaaaatcttt ctacattctg   73140
gatgagccga cgacagggct tcatacagag gacattgctc gcctgctcaa ggttttagct   73200
cgctttgtag acgatggcaa tacagtcctc gtcatcgagc acaatctgga tgttatcaag   73260
acggcagacc atatcattga cttgggacct gagggcggtg tcggtggtgg aaccatcatc   73320
gtaacaggaa ctccagaaga agtagctgcc aacgaagcca gctatacagg acactatttg   73380
aaaggaaagt tacatcatga ataaacgcgt acaagcattt ctagctaaaa tgcaagaaaa   73440
agaactagat ggtatcatca tcaacaatct taaaaacgtc tattatttga ctggtttttg   73500
gggctcaaac ggaacagtct ttatcagtcg tgaccgtcag gtcttagtga cagactctcg   73560
ctatatcatc gcagctaagc aagaaaccag tggttttgag attgtggctg atcgtgatga   73620
attggctgtc attgcaggaa ttgttaagga catgggcttg actcgtatcg gttttgaaga   73680
tgagatttca gtgtcttatt accaccgtat gcaggcagct tttgcaggtt tgaacttgct   73740
tccacaaact cagtttgtgg aaggtcttcg tatgattaag gatgaggcag agattgcagc   73800
gattcgcaag gcttgttcta tctcagacca agctttccgc gatgcgcttg actttatcaa   73860
accaggaaaa actgaaattg agattgccaa cttccttgat ttccgcatgc gtgagttggg   73920
agcatctggc ttatcttttg atacgatcct agctagcggt atcaattctt ctaaacccca   73980
tgcccatcca atgcacaaac cagtggagtt gggagaagcc atcaccatgg acttcggctg   74040
tctctatgac cactatgtca gtgatatgac ccggactatc tatctagggc atgttagcga   74100
tgagcaggca gagatttaca atacggttct aaaagctaac caagccttga ttgaccaagc   74160
taaggcaggc ttaggtttcc gtgactttga caaaatccct cgtgatatta tcattgaggc   74220
aggttatggt gactacttta ctcacggcat tggccacggt attggtctgg atatccatga   74280
ggaaccctac tttagtcaga cttctacaga aactattaag acaggtatgg ccttgaccga   74340
tgaaccaggt atctatatcg aaggcaaata tggcgttcgt atcgaggatg atatcctgat   74400
tacagagaca ggttgtgaat tattgaccct agctccaaaa gagttgatag tcatttagtt   74460
gtttgtcaag aaaaaagtac gaaaatgacg aaaaaagtca aaaaaaatta aaaataggtc   74520
gcaagtcgga tgttttttat ggtataatag actaaactga tagtaacatg tagcgaaagg   74580
ggtaggtaca tgattaaaat ttatacagtc tcaagttgta ctagctgtaa aaaagcaaaa   74640
acctggctca atgcccacca gttaagttat aaagaacaaa accttggtaa agaaggaatt   74700
acgagagaag aattactgga tattctaacc aaaacagata acggaatagc cagcatcgtt   74760
tcgtctaaaa atcgctatgc caaagccctt ggagtggata ttgaagattt gagtgtcaat   74820
gaagttctca atctgattat ggaaacaccg agaattttaa agagcccaat ccttgtagat   74880
gaaaaacgcc tgcaagttgg ctacaaggaa gacgatattc gtgccttcct accacgctct   74940
gtccgtaatg tagaaaatgc agaagcacgt ttgcgtgcag ctctataaac atcaaggctg   75000
ggagcacttc ccagtcttat tctattttaa tttcaaaaag aaagaagaaa gaaatgaaaa   75060
aaatagttct tgttagtcta gctttccttt ttgtcctggt tggttgcgga cagaaaaaag   75120
aaactggacc agctacaaaa acagaaaaag atacgcttca gtcggcattg ccagttattg   75180
aaaatgctga gaagaataca gttgtaacta agactttggt cttgcccaag tcagatgatg   75240
gtagccagca gacacaaaca attacttaca aagacaagac ttttttgagt ctagctatcc   75300
aacaaaaacg tccagtctct gatgagttga agacttatat tgaccaacat ggagtggagg   75360
aaactcaaaa agctcttctt gaagcggagg agaaggataa gtctatcatt gaagctcgta   75420
aattggcagg tttcaaactt gaaacaaaac tattgagcgc aacggaactt caaacaacga   75480
ctagttttga ttttcaagtt ctggatgtca agaaggcttc ccagttggaa catctgaaga   75540
atattggttt ggaaaatctt ttgaaaaatg aaccaagcaa atatatttca gatagattgg   75600
caaatggcgc gacagaacaa tagaaaatcc aaataaatag actgcctgaa ttgtagaagg   75660
taaggaatta tgctataatg gtactattct aaggaaagag ggtgttagaa tgggatttac   75720
tgaagaaaca gtacgtttta aattggacga ttccaataaa aaagaaatta gcgaaacttt   75780
gacagatgtt tatgcttcgt tgaacgataa gggttacaac ccaattaacc aaatcgtagg   75840
ttacgtattg agtggagacc ctgcctacgt tcctcgttat aataatgcac gaaatcaaat   75900
ccgtaagtat gagcgtgatg aaatcgttga ggaattggtt cgctactacc tcaaaggaca   75960
aggagtcgat ctataaccta tgagaattat gggattggac gtcggttcaa aaacggtagg   76020
ggtggcgatt agcgatccgc ttggttttac agctcaaggg cttgaaatca tccagataaa   76080
tgaagaacaa ggccaatttg gttttgaccg cgttaaggaa ttggttgata cttacaaggt   76140
ggaacgattt gtagtgggct tgcctaaaaa catgaacaat acaagtggac cgcgcgtaga   76200
agctagtcaa gctacggagc aaagctagaa gagttttttg gtttaccagt agactatcag   76260
gatgaacgct tgacaacagt ggctgctgag cgcatgttga ttgaacaagc agatatcagt   76320
cgcaataagc gcaagaaagt cattgataag ttagcagctc agctgatttt acaaaattat   76380
ttagatagaa aattttaata taaaggagag gctatgtcac acgatcataa ccacgaccac   76440
gaagaacgtg aactaatcac actagtagat gagcaaggaa atgaaacctt gtttgaaatc   76500
cttttgacaa ttgatggaaa agaagaattt ggtaaaaact atgttcttct agtaccagtt   76560
aacgcagaag aagacgaaga cggacaagtt gaaatccaag cttactcatt catcgaaaac   76620
gaagatggaa cagaaggcga attgcaacca atcccagaag actcagaaga cgaatggaac   76680
atgattgaag aagtcttcaa cagctttatg gaggagtgat acagtctggg agactgtatc   76740
agcccaactc ccagaaatgg ggaagagttg gaacgtccag tgaacatttt taccccaact   76800
cccagaaatg gggaagagtt ggaacgtcca gtggatgttt ttagcccata ttcacattca   76860
tagtagctag ttattagcta accaggtaag aggtcgggac gaaaatcctg gccttgtttt   76920
tattagtaac catactttaa tgcgataatt gattggactt ttgtcaagga gatgtgtatg   76980
tttgaagtag aagaatggct ccatagtcgg attggtttga attttcgatc aggtttgggt   77040
cgaatgcagc aagcggtgga tttgttagga aatcctgagc agtcttaccc tattatccac   77100
gtaacaggga ctaatgggaa aggatctacc attgctttta tgagggaatt atttatgggg   77160
catggcaaaa aagttgcgac ctttacctcc cctcatatcg tctctatcaa tgaccgaatc   77220
tgcattaatg ggcagcctat agcagacgca gactttatcc gtttgactga tcaggtcaag   77280
gagatggaga aaacgcttct gcaaactcct gcccagttgt ccttttttga attgctgacc   77340
ttggttgctt ttctttattt tagggagcag gaggtggatt tggttttatt agaagtggga   77400
attggtggct tacttgacac gaccaatgtg gtaactggag agtttgctgt catcacctcc   77460
attgggcttg accatcaaga aaccttgggt gatagtctag aagcaattgc agagcagaaa   77520
gctggtattt tcaaggctgg taagaaggca gtgattgcga aattgcctcc agaagctagg   77580
cttgcctgtc agaaaaaagc cgaatcttta gctgttaacc tttatcaggc aggtcaagat   77640
tttttaatgc tgaatggtga tttttcaagc tctttactaa atctttcaca gctgaacata   77700
ggcttagaag gagtctatca gcaggagaat gcagccttgg cgttgcaaac ttttcttctt   77760
tttatgagag aaagaaagga agctgttgat gaacaggctg taagaaaggc cttggaacag   77820
acccattggg ctggtcgctt ggagcgtatt cgcccacaga tttatttgga tggtgctcat   77880
aacctccctg ccttgactcg cttggctgag tttatcaaag aaaaagagca ggaaggctat   77940
cgacctcaaa tcctctttgg atccttgaaa cgtaaggatt atcaagggat gttgggttat   78000
ctgactgaaa aattgcctca ggtggaactc aaggtgaccg gctttgacta tcagggggct   78060
ttggacgaaa gggatgtgac aggttacgat atagtttctt cttaccgaga atttatcagc   78120
gattttgaag aaagggcaga cgctcaagac ttgctgttcg ttacagggtc tctctatttt   78180
atctcagaag tacggggcta cctgctggac cgtgagcaga taaattgact ccattttttg   78240
aacttgttat actaggggaa ttgctggtta gagaaaattt ctctaaattg gtagcagaaa   78300
ggaaattcat catgaaatta aaaagattca cactttctct tgcttctcta gcaagtttta   78360
gtctcttagt agcttgttca caaagagctc aacaggttca acagcctgtt gctcagcagc   78420
aggtccaaca acctgctcaa cagaatacca atactgcaaa tgcaggaggt aaccaaaatc   78480
aagcggctcc agtacaaaac caacctgttg ctcaaccgac cgatattgat gggacttata   78540
ctggtcagga tgacggagac cgtatcactt tagtggtaac tggaacgact ggtacatgga   78600
ctgagctcga atctgacggg gatcagaaag tcaaacaggt tacattggat tcagcaaatc   78660
aacgcatgat tattggcgat gatgtcaaaa tttacactgt aaacggtaat caaatcgtcg   78720
tagatgatat ggatagagac ccatcggacc aaatcgtttt aactaaataa gactatgcaa   78780
gtagaaaggg ctggattttt cagccttttt acttttacct agaaaataat cataaatact   78840
tgccttctac cgaatacctg cgttatacta gtatcaatta cttgttttta gcattcaaac   78900
tatcaaggag gggatatgaa atataggaaa tttcaattat tgatgtccaa gtatggcttt   78960
agtctttcga ttatgctact tgaactttgt cttgtttttg gtctctttct ttatttagga   79020
cgcatggctc ccattttatg gattactgtc ctcattctac tgagtatcat cacaatcatt   79080
tcgatagtca accgtaatac gactcctgag aataaggtaa cctggttgtt agtagccttt   79140
gtgccagtat ttggtccctt gctctatctg atgtttggtg aaaggcgatt gtccaaaaaa   79200
gaaatcaaac aactgaagaa gctaggctct atgcatttcc aagaagcaaa tagccagcta   79260
ctaaaagaga aattaaaaga aagtgacaag gcagcttatg gagtcatcaa gtccttattg   79320
agtatggata ccaatgctga catctatgat caaactgcct ctacattttt tcctaacgga   79380
gaagctatgt ggaaaaagat ggtagaagat cttaaaaagg ctgagaaatt tattttcttg   79440
gaatattaca ttatagaaga aggtttgatg tggaatcgca tactagatat actagagcaa   79500
aaggtagctc agggtgtaga ggttaagatg ctctatgatg atatcggctg tatggctact   79560
ttaacaggag attatgcaca tcgacttcgt cagctgggca tcgaggccca taaattcaat   79620
aaagttattc ctcgtttgac agtggcttat aataacagag atcatagaaa aatattgatt   79680
gttgatggtc agatagccta tactggtggg gtcaatctgg cagatgagta cattaaccac   79740
gtcgagagat ttggttattg gaaggatagt ggaattcgct tagacggact agcagtaaaa   79800
gctctgacac gcttattttt gaccacttgg tacattaatc gaggagaaat tagtgatttt   79860
gatcaatatc atttagaaaa tcattctatc ccgagtgacg gtttaaccat tccatacgga   79920
agtggaccca agccaatttt tcgagcgcag gtagggaaaa aagtttatca gagtttaatc   79980
aatcaagcaa cagaatcggt ctatattacg acaccttatt tgattataga ttatgattta   80040
acagagacaa tcaaaaatgc agctatgaga ggggtcgatg ttcgaattat caccccttac   80100
ataccagata agaagttcat tcagttagtc acgagaggag cttatcccga ccttctttct   80160
gctggtgttc ggatttatga gtatagtcca ggttttattc atagtaagca gatgttggta   80220
gacgaagatt ttgcggtggt ggggacaatc aatctcgact accggagctt ggtacaccat   80280
tatgaaaatg cagtcttact ctataaaact ccttctataa gggaaatcgc ccgagatttt   80340
cgaaatatat ttgcagattc tcaggaagtc tatcctcatt ctatcaaaac gagctggtat   80400
caaaagcttg taaaagaaat cgcccagcta ttcgccccta tcttataaga aatctaggac   80460
ttaggataca aaccagacct atttttcttg tcttttacga atagaaagaa agaggagggg   80520
aattcatgct aactaaggaa gaagtgaatg atatgattga gttcaaacag acacatttac   80580
accgctttcg ggaaattgaa acctttgtga aactatgcaa aaaatcactc aaacagccat   80640
cgcaagctga caatcctagg actttttgat atactaagac agataaattg aacaggagaa   80700
acgatatgag tgtgtatggt agagtagaag aagttcataa ggagaatcgt gaacctctag   80760
aataccaaat cgaacaagaa tcgcatcatc gtgaatcaag tcgtcttcct ttggtgaaaa   80820
ttttactatg gagtacgctt gtaacgggga taactctagg agtaccgcta ttactcgact   80880
taatgagtgc acaagaagtg caggattttt atgcaggttg ggcgcttcat cagacaggga   80940
agatttacag cgactattat ggaagtcaag gtttgcttta ttatttgctg acttacgtga   81000
gtcagggcgg atttttcttt gccatctttg agtggttagc cttggtagca ggaggatttt   81060
tcctttttag atcagcggac accttgacag agcaaggaga ccaagctgga catctggtga   81120
ctatttttta catgctagtt acaggtcttg cttttggtgg aggctatgcg actcttttag   81180
cgcttccttt cttattcgca gcctttagtt tagttgcggc ttacctaagc aatccaagcc   81240
atgataaggg atttgtacgg attgggctag ctttggcagg cggatttttc tttgctccct   81300
tatcatcgct cctgtttatt gctgtagtga gtttaggctt gttggtcttt aaccttgggc   81360
atagacgctt tgcgcatggg ttttatcagt ttcttgcagt ggctttaggt ttttcacttg   81420
tcttttatcc aactgcctac tatagtgctg caacaggaag ttttggggat gcgattagtg   81480
gtattcgtta tcctattgac agtattcgct ttgattttac ttctaaaatt ttagagaata   81540
tgttttttta tggcttgttg tcccttggtt tgggatttgt ggtttgtatc tttttaggtc   81600
tctttcaatc caaacccttt aaactatacg tcatttcggt tcctgcaagt cttgtggtaa   81660
ttttaggttt gattttactt ttcttttcac aagagcctct gcacgcttct tatttgatgg   81720
tcgtcttccc tgttttccta cttttattgg taaccaatat taagagtcaa cagagggggc   81780
gtagtgctag aagaagccga agagaaacgc cagttagcct atggagtcgt ttcttcaaag   81840
gaaatctata tctgctagtt tttgggtttg tctatctttt gtctgttcct tttttgatga   81900
agtttgtcct ttatccagta ccttatcaag aacgtaatcg tcttgctgat ttggtaaaag   81960
aggagacaaa tacggaagat gctatctcat gcatgggatg atactgcgac tctttatcgt   82020
aagagtgagc gcttgtcgcc atcggcgatt ttgtccccgt tgcactatac agcaactgag   82080
gaaaatcgta ataagttact taatgacttg aaagaaaaac aacctaaggt gattgtggta   82140
aatgataagg tggtagtctg gtctgaagtg gaaacactct taaaagaaaa ttaccaacaa   82200
gtaaagactg attactcaga gtttaaagtc tataaaatta aataaccaaa tcaatatctt   82260
gtgtattttt aaaaatttta ggatttttaa cacaagatat tgatttttct ttttagagtg   82320
gtataatact ttttagaaag aacattttag aaaagagcat gcatatgatt gcactagaag   82380
aaaaaattac aattttgcca actctcttcg tcgagaaacg agatgggaga cgtgttgtat   82440
ttgatgtgga caagattgac aaggctctcc acaaggcggc tgacaaggtt atggatgtga   82500
cacccctggt tgaaaaatgc ctcaatgatc tgactgagcg aattattaca gaaattcata   82560
gtcgctttcc acagggaatt aagatttacg aaattcaaaa tatcgtagaa catgaactcc   82620
ttgaagccaa agaatatgcg ctggctgagg agtatattac ttatcggaca cagagggatt   82680
ttgagcgctc aaaagcgacg gatatcaact ttagtattca taaacttctc aacaaagacc   82740
agacagttgt caatgaaaac gctaataaag acagtgatgt ctttaacact cagcgtgatt   82800
tgacagcagg gattgttggg aaatcaatcg gactgcaaat gcttcctaag cacgtagcca   82860
atgcccacca aaagggggat atccactatc acgatttgga ctacagtccc tataccccta   82920
tgaccaactg ctgtttgatt gattttaagg gtatgttgga aaatggtttt aagattggaa   82980
atgcagaggt agagagtccc aagtctatcc agactgcgac agcacagatt tctcaaatca   83040
ttgccaacgt tgcttctagc cagtacggtg gctgttcagc tgaccgtatc gatgaaattt   83100
tggcgcctta tgcagagaag aattatcaaa aacatctcaa agatgcagaa gagtgggtat   83160
tgcctgaaaa acaggaagat tacgcttgga agaaagcgca aaaggacatc tacgatgcca   83220
tgcaatctct tgagtatgaa atcaatactc tcttcacttc aaatggacaa acacctttta   83280
cttcgttagg ttttggtctg ggaaccagtc gttttgaacg agaaattcaa aaagctattt   83340
taaacattcg catcaagggt cttggttcag aacaccgtac ggctatcttt cctaaactta   83400
tctttacgct taaaagaggc ctcaacttag aggaaggaac tcccaactat gacatcaagc   83460
agttggctct agagtgtgca accaagcgga tgtatccaga cgtcttgtct tatgataaga   83520
ttgttgattt gacaggttct ttcaaggtgc ctatgggctg ccgttctttc cttcaagggt   83580
ggaaggatga aaatggtgta gaagtcaatt caggtcgcat gaatctgggt gttgtgacgg   83640
ttaatctgcc tcgtattgct cttgagtctg aaggtgatat gaataagttc tgggaaatct   83700
tcaacgagcg aatgaatatc gcagaagatg ctcttgttta ccgtgtcgaa cgcactaaag   83760
aggcgacacc agcgaatgct cctattcttt atcagtacgg tgcttttggc catcgtctag   83820
gtaaagaaga aagtgttgac cagctcttta agaatcgtcg tgcgaccgtt tcgctgggct   83880
atatcggctt gtatgaagta gcgacagttt tctttggtaa cagctgggaa agtaatccag   83940
atgctaagga attcacgcta gacatcattc acgatatgaa acgccgtgta gaagagtggt   84000
cagaccaata tggctaccat ttctctatct actcaacacc atccgaaagt ctgacagacc   84060
gtttctgccg actagatata gacaagtttg gctctattcc tgatatcaca gacaaggaat   84120
actacaccaa ctctttccac tacgatgttc gtaaaaatcc aacaccgttt gaaaaattgg   84180
actttgagaa agtctatccg gaagcaggtg cgtcaggtgg tttcatccat tattgtgagt   84240
atccagtcct tcagcaaaat ccaaaggcct tggaagctgt ctgggattat gcttatgacc   84300
gtgtaggcta tctaggcacc aatactccga ttgaccgttg ctacaagtgt gactttgaag   84360
gggattttga accaactgag agagggtttg cttgtccaaa ctgtggcaat agcgacccta   84420
aaacagtaga tgtggtgaaa cgaacttgtg gctacctagg taatcctcaa gcaagaccga   84480
tggtcaacgg gcgtcacaag gaaatcgctg cgcgtgtcaa acatatgaat ggttcaacga   84540
ttaaaatagc tgggcatcaa gtaacaaatt agaaagaaat gaaatgggaa aatatcaact   84600
agacgataag gggcgcgcac aagtgacccg ttatcacgag aaacactcta aaggtggagc   84660
tggtaagaaa gaacgcttgc ttagcttcag agaacaattt ttaaacaaga acaagaaaaa   84720
ataaaagtga gagccagctc tcgcttttct catagtggga ggtaaggatg gaattacgca   84780
gaccaagatt agcggataag aaagctgttt tagatatgat gacagagttt gaaaaatttc   84840
agtcgcctca cgacggcggt ttctgggata cagagaactt tgtgtatgaa gactggttag   84900
aaagcaatca ggaacaggaa atggggatta atctgcctga aggatgggtt tctgcaattc   84960
agttagtggc tttttctgag aaaggtcaag cagttggatt tcttaatctc cggttgcgcc   85020
tcagtaactt tctactagaa gaaggtggcc acattggcta ctccattcgt ccatctgaaa   85080
gaggcaaggg ttatgcaaaa gagactctcc gtcagggctt gcaagttgct aaggaaaaga   85140
acatcaagaa agctctggtg acctgtagtg tgaataatcc tgctagcaga gcagtcattc   85200
tagcaaatgg tggaatattt gaggatgctc gcaatggagt cgagcgttat tggatagagg   85260
tagcgaatga ataatccaaa accacaagaa tggaaaagcg aggaacttag tcaaggtcgt   85320
atcattgact acaaggcctt taactttgtg gacggcgaag gcgtgcgcaa ctctctctat   85380
gtatcaggct gtatgtttca ctgcgaggga tgttataatg ttgcgacttg gtcttttaat   85440
gctggcattc cctatacagc agaattagaa gagcagatta tggcagacct tgcccaaccc   85500
tatgttcaag gcttgacttt gctgggaggg gagccttttc tcaatactgg gattctcttg   85560
ccacttgtta agcggattcg gaaggaattg ccagacaagg acatctggtc ctggaccggc   85620
tacacttggg aagaaatgat gttggaaact ccagataaac tggaattctt gtcactgatt   85680
gacattcttg tcgatggaag atatgatcga actaagagaa atcttatgct ccagtttcga   85740
ggttcatcta accaacgaat tatcgatgtg caaaaatcgc tcaaaagtgg gcaagtagtg   85800
atttgggaca agctcaatga cggaaaagaa agctatgaac aggtgaagag agaatgaaga   85860
aaaaggactt agtagaccaa ctagtctcag agatcgagac ggggaaagtc aggacactgg   85920
gaatatacgg tcatggagct tcaggtaaat caacctttgc acaggaattg taccaagctt   85980
tagattctac tacagtaaat ttgctagaga cagatcctta tatcacctca ggacgccatc   86040
tggtagtacc caaggacgcg ccgaatcaaa aggtgacagc cagtctgcca gtggcgcatg   86100
aactggagag tttgcagaga gatatccttg cttgcaggcg ggtatggatg tcttgacaat   86160
tgaagaacct tggaaggcta gtgaggtctt gtctggagcc aaaccaattt tgattgtcga   86220
agggatgtct gttggctttc tacccaagga actctttgaa aaaaccatct gtttctacac   86280
ggatgaggag accgaattaa agcgacgcct tgctagagat acgactgtga gaaatcgcga   86340
tgcatccttt atattggcta gccatcagat gagacgggag cagtatctgc gatactataa   86400
agaaactgag tctaaggcgg atatcttagt ggaccaatca gaagataaat ttgatgtcaa   86460
gaggacttaa cttatgtata gaagaaatat agaagaaaat ccctaatttt agaaagaaaa   86520
agtaggaaaa cagtttcatc ccaaaaaaac gaaaaaacag caacaaatcc cttgcaatcg   86580
caggggcttt gtgttattct attatggtgc tgtaaattac agccttagtt ttgatgcaag   86640
aggttgcgac acgctcggtt gcattgccac gcaacaccgc gtcggttttc ttgtggagct   86700
agcctattat cttaaataga cgaaaaggag aaaaagatgg caaacaaaaa aatccgtatc   86760
cgtttgaaag cttacgaaca ccgtacgctt gacacagcgg ctgcaaaaat cgtagaatca   86820
gctactcgta caggtgcaca agttgcgggt ccaatcccac ttccaactga acgtagcctc   86880
tacacaatca ttcgtgcgac tcacaaatac aaagactctc gcgaacaatt tgaaatgcgt   86940
acacacaaac gtttgatcga tatcgttaac ccaactcaaa aaacagttga tgccttgatg   87000
aaattggatc ttccaagtgg tgtaaacgta gaaatcaaac tttaatctaa aatataaaag   87060
agcagaggct ggtgtttcaa tctaattgaa cacgggctaa actcggtgtg aaaaagataa   87120
acttcctagt gtctgctaga cactgcgtca gtttcctatt ttcacgttga gtttgacgcc   87180
ctttgtatct tagacttgag cataaaaaac gctcgttaaa aactttttga ataaaaaata   87240
tagaaaagga actattttct catgacaaaa ggaatcttag ggaaaaaagt gggaatgact   87300
caaatcttca ctgaagctgg cgaattgatc cctgtaacag ttattgaagc aactccaaac   87360
gttgttcttc aagttaaaac tgttgaaaca gacggataca acgctatcca agttggtttc   87420
gatgacaaac gcgaagtatt gagcaacaaa cctgctaaag gacatgtagc gaaagctaac   87480
acggctccta agcgcttcat tcgtgaattc aaaaacgttg aaggcttgga agttggtgct   87540
gaaattacag ttgaaacatt cgcagctgga gacgttgttg acgtaacggg tacttctaaa   87600
ggtaaaggtt tccaaggtgt tatcaaacgc cacggacaat cacgtggacc aatggctcac   87660
ggttctcgtt accaccgtcg tccaggttct atggggcctg ttgcacctaa ccgcgtattc   87720
aaaggtaaaa accttgcagg acgtatgggt ggcgaccgcg taacaattca aaaccttgaa   87780
gttgtacaag ttgttccaga aaagaacgtt atccttatca aaggtaacgt accaggtgct   87840
aagaaatctc ttatcactat caaatcagca gttaaagctg gtaaataata aagaaagggg   87900
aaatcagtca caatggcaaa cgtaacatta tttgaccaaa ctggtaaaga agctggccaa   87960
gttgttctta gcgatgcagt atttggtatc gaaccaaatg aatcagttgt gtttgatgta   88020
atcatcagcc aacgcgcaag ccttcgtcaa ggaacacacg ctgttaaaaa ccgctctgca   88080
gtatcaggtg gtggacgcaa accatggcgt caaaaaggaa ctggacgtgc tcgtcaaggt   88140
tctatccgct caccacaatg gcgtggtggt ggtgttgtct tcggaccaac tccacgttca   88200
tacggctaca aacttccaca aaaagttcgt cgcctagctc ttaaatcagt ttactctgaa   88260
aaagttgctg aaaacaaatt cgtagctgta gacgctcttt catttacagc tccaaaaact   88320
gctgaatttg caaaagttct tgcagcattg agcatcgatt ctaaagttct tgttatcctt   88380
gaagaaggaa atgaattcgc agctctttca gctcgtaacc ttccaaacgt gaaagttgca   88440
actgctacaa ctgcaagtgt tcttgacatc gcaaatagcg acaaacttct tgtcacacaa   88500
gcagctatct ctaaaatcga ggaggttctt gcataatgaa tttgtatgat gttatcaaaa   88560
aacctgtcat cactgaaagc tcaatggctc aacttgaagc aggaaaatat gtatttgaag   88620
ttgacactcg tgcacacaaa cttttgatca agcaagctgt tgaagctgct ttcgaaggtg   88680
ttaaagttgc caatgttaac acaatcaacg taaaaccaaa agctaaacgt gttggacgtt   88740
acactggttt tactaacaaa actaaaaaag ctatcatcac acttacagct gattctaaag   88800
caatcgagtt gtttgctgct gaagctgaat aatctaagga ggaaatatcg tgggaattcg   88860
tgtttataaa ccaacaacaa acggtcgccg taatatgact tctttggatt tcgctgaaat   88920
cacaacaagc actcctgaaa aatcattgct tgttgcattg aagagcaagg ctggtcgtaa   88980
caacaacggt cgtatcacag ttcgtcacca aggtggtgga cacaaacgtt tctaccgttt   89040
ggttgacttc aaacgtaata aagacaacgt tgaagcagtt gttaaaacaa tcgagtacga   89100
tccaaaccgt tctgcaaaca tcgctcttgt acactacact gacggtgtga aagcatacat   89160
catcgctcca aaaggtcttg aagtaggtca acgtatcgtt tcaggtccag aagcagatat   89220
caaagtcgga aacgctcttc cacttgctaa catcccagtt ggtactttga ttcacaacat   89280
cgagttgaaa ccaggtcgtg gtggtgaatt ggtacgtgct gctggtgcat ctgctcaagt   89340
attgggttct gaaggtaaat atgttcttgt tcgtcttcaa tcaggtgaag ttcgtatgat   89400
tcttggaact tgccgtgcta cagttggtgt tgtcggaaac gaacaacatg gacttgtaaa   89460
ccttggtaaa gcaggacgta gccgttggaa aggtatccgc ccaacagttc gtggttctgt   89520
aatgaaccct aacgatcacc cacacggtgg tggtgaaggt aaagcaccag ttggtcgtaa   89580
agcaccatct actccatggg gcaaacctgc tcttggtctt aaaactcgta acaagaaagc   89640
gaaatctgac aaacttatcg ttcgtcgtcg caacgagaaa taatattaaa ctagtcgctt   89700
aagcaactag taaatccgcc agctcggtag cgctccatag gagtgcaagc cgctgtggta   89760
caacatttaa aggagaaaat ataaaaatgg gacgcagtct taaaaaagga cctttcgtcg   89820
atgagcattt gatgaaaaaa gttgaagctc aagctaacga cgaaaagaaa aaagttatta   89880
aaacttggtc acgtcgttca acgatcttcc caagtttcat tggttacact attgcagttt   89940
atgacggacg taaacacgta cctgtttaca tccaagaaga catggtaggc cacaaacttg   90000
gtgaatttgc accaactcgt acttacaaag gtcacgctgc agacgacaag aaaacacgta   90060
gaaaataagg agaacataaa tggcagaaat tacttcagct aaagcaatgg ctcgtacagt   90120
acgtgtttca cctcgtaaat cacgtcttgt tcttgataac atccgtggta aaagcgtagc   90180
cgatgcaatc gcaatcttga cattcactcc aaacaaagct gctgaaatca tcttgaaagt   90240
tttgaactca gctgtagcta acgctgaaaa caactttggt ttggataaag ctaacttggt   90300
agtatctgaa gcattcgcaa acgaaggacc aactatgaaa cgtttccgtc cacgtgcgaa   90360
aggttcagct tcaccaatca acaaacgtac agctcacatc actgtagctg ttgcagaaaa   90420
ataaggaggt aaaatcgtgg gtcaaaaagt acatccaatt ggtatgcgtg tcggcatcat   90480
ccgtgattgg gatgccaaat ggtatgctga aaaagaatac gcggattacc ttcatgaaga   90540
tcttgcaatc cgtaaattcg ttcaaaaaga acttgctgac gcagcagttt caactattga   90600
aatcgaacgc gcagtaaaca aagttaacgt ttcacttcac actgctaaac caggtatggt   90660
tatcggtaaa ggtggtgcta acgttgatgc actccgtgca aaacttaaca aattgactgg   90720
aaaacaagta cacatcaaca tcatcgaaat caaacaacct gatttggatg ctcaccttgt   90780
aggtgaagga attgctcgtc aattggagca acgtgttgct ttccgtcgtg cacaaaaaca   90840
agcaatccaa cgtgcaatgc gtgctggagc taaaggaatc aaaactcaag tatcaggtcg   90900
tttgaacggt gcagatatcg cccgtgctga aggatactct gaaggaactg ttccgcttca   90960
cacacttcgt gcagatatcg attacgcttg ggaagaagca gatactacat acggtaaact   91020
tggtgttaaa gtatggatct accgtggtga agttcttcca gctcgtaaaa acactaaagg   91080
aggtaaataa ccaatgttag tacctaaacg tgttaaacac cgtcgtgagt tccgtggaaa   91140
aatgcgcggt gaagcaaaag gtggaaaaga agtagcattc ggtgaatacg gtcttcaagc   91200
tacaactagc cactggatca ctaaccgcca aatcgaagct gctcgtatcg ccatgactcg   91260
ttacatgaaa cgtggtggta aagtttggat taaaatcttc ccacacaaat catacactgc   91320
taaagctatc ggtgtgcgta tgggatctgg taaaggggca cctgaaggtt gggtagcacc   91380
agttaaacgt ggtaaagtga tgttcgaaat cgctggtgta tctgaagaga ttgcacgtga   91440
agcgcttcga cttgctagcc acaaattgcc agttaaatgt aaattcgtaa aacgtgaagc   91500
agaataagga gaaggcatga aacttaatga agtaaaagaa tttgttaaag aacttcgtgg   91560
tctttctcaa gaagaactcg cgaagcgcga aaacgaattg aaaaaagaat tgtttgaact   91620
tcgtttccaa gctgctactg gtcaattgga acaaacagct cgcttgaaag aagttaaaaa   91680
acaaatcgct cgcatcaaaa cagttcaatc tgaagcgaaa taatagacta gggaaggaga   91740
aatttcaatg gaacgcaata atcgtaaagt tcttgttgga cgtgttgtat ctgacaaaat   91800
ggacaagaca atcacagttg tagttgaaac aaaacgtaac cacccagtct atggtaaacg   91860
tattaactac tctaaaaaat acaaagctca tgatgaaaac aatgttgcca aagaaggcga   91920
tatcgtacgt atcatggaaa ctcgcccgct ttcagctaca aaacgtttcc gtcttgtaga   91980
agttgttgaa gaagcggtca tcatctaatc aaacctgaaa ggagaaaact gaaatgattc   92040
aaacagaaac tcgtttgaaa gtcgcagaca acagcggtgc tcgcgaaatc ttgactatca   92100
aagttcttgg tggttcagga cgtaaatttg caaacatcgg tgatgttatc gtggcatctg   92160
taaaacaagc tactcctggt ggtgcggtta aaaaaggtga cgttgttaaa gcagttatcg   92220
ttcgtactaa atcaggtgct cgtcgtgctg atggttcata catcaaattt gacgaaaacg   92280
cagcagttat catccgtgaa gacaaaactc ctcgcggaac acgtatcttt ggcccagttg   92340
cacgtgaatt gcgtgaaggt ggcttcatga agatcgtgtc acttgctcca gaagtacttt   92400
aatttttagg aacaaactag tcccctagct tcaagctagg gtgcccttat gggcgtaaga   92460
aaaatcaagg agaaacctaa tgtttgtaaa aaaaggcgac aaagttcgcg taatcgctgg   92520
taaagataag ggaacagaag ctgttgtcct tactgccctt ccaaaagtaa acaaagttat   92580
cgttgaaggt gttaacattg ttaagaaaca ccaacgtcca actaacgagc ttcctcaagg   92640
tggtatcatc gagaaagaag cagctatcca cgtatcaaac gttcaagttt tggacaaaaa   92700
tggtgtagct ggtcgtgttg gatacaaatt tgtagacggt aaaaaagttc gctacaacaa   92760
aaaatcaggc gaagtgcttg attaatcacg aaggaaagga gaagtataat ggcaaatcgt   92820
ttaaaagaaa aatatcttaa tgaagtagtt cctgctttga cagaacaatt caactactca   92880
tcagtgatgg ctgtgcctaa agtagataag attgttttga acatgggtgt tggtgaagct   92940
gtatcaaacg ctaaaagcct tgaaaaagct gctgaagaat tggcacttat ctcaggtcaa   93000
aaaccactta tcactaaagc taaaaaatca atcgccggct tccgtcttcg tgaaggtgtt   93060
gcgatcggtg caaaagttac ccttcgtggt gaacgtatgt acgaattctt ggataaattg   93120
gtatcagttt cacttccacg tgtacgtgac ttccacggtg tcccaacaaa atcatttgat   93180
ggacgcggga actacacact tggtgtgaaa gaacaattaa tcttcccaga aatcaacttc   93240
gatgacgttg acaaaactcg tggtcttgac atcgttatcg taacaactgc taacactgac   93300
gaagagtcac gtgcattgct tacaggcctt ggaatgcctt ttgcaaaata atataggagg   93360
taaatctaat ggctaaaaaa tcaatggtag ctagagaggc taaacgccaa aaaattgttg   93420
accgttatgc tgaaaaacgt gctgcattaa aggcggcagg ggactacgaa ggtttatcta   93480
aattacctcg caacgcctca ccgactcgtt tacataatcg ttgtagggtt acggggcgcc   93540
cacattcagt ttaccgcaaa tttggtctga gtcgtatcgc ttttcgcgaa cttgcgcata   93600
aaggtcaaat tcctggtgta acaaaagcat cttggtaatt taagatatca agagcgtcaa   93660
aactccaagt aaaaatagga aacttgacga agaaactaaa gtttctagga aagtttatct   93720
ttttcacaca gagtttagcc cgggttcaat tgggcttgcc aatttgaaca cgagctacag   93780
ctttggcaaa aaagaccaat ttgctttgga gcattgcttc tgcattaaat tgtctatttt   93840
tgctcgtgct gttacgctct ttgtatcatg tattaactag caagtgcaac ttgcaaacta   93900
ctagtaagag gagaaaaaca aaatggttat gactgaccca atcgcagact tcctaactcg   93960
tattcgtaat gctaaccaag ctaaacacga agtacttgaa gtacctgcat caaacatcaa   94020
aaaagggatt gctgaaatcc ttaaacgcga aggttttgta aaaaacgttg aaatcattga   94080
agatgacaaa caaggcgtca tccgtgtatt tcttaaatac ggaccaaatg gtgagaaagt   94140
tatcactaac ttgaaacgtg tttctaaacc aggacttcgt gtctacaaaa aacgtgaaga   94200
ccttccaaaa gttcttaacg gacttggaat tgccatcctt tcaacttctg aaggtttgct   94260
tactgataaa gaagcacgcc aaaagaatgt tggtggtgag gttatcgctt acgtttggta   94320
aaatcaagat acaaagctcg taaagaacaa agcaaaatta ggaagttgga gaagtttgtt   94380
tacaaacaag ccaacttatc tattttgcac agttcttaga gcgtgttcag ttcagctctt   94440
gaactaaata agtatctgaa ccccgtgaaa actggccgtt ctggcctgac aatttaacag   94500
gagaaaataa acatgtcacg tattggtaat aaagttatcg tgttgcctgc tggtgttgaa   94560
ctcgctaaca atgacaacgt tgtaactgta aaaggatcta aaggagaact tactcgtgag   94620
ttctcaaaag atattgaaat ccgtgtggaa ggtactgaaa taactcttca ccgtccaaac   94680
gattcaaaag aaatgaaaac tatccacgga actactcgtg cccttttgaa caacatggtt   94740
gttggtgtat cagaaggatt caagaaagaa cttgaaatgc gtggggttgg ttaccgtgca   94800
cagcttcaag gatctaaact tgttttggct gttggtaaat ctcatccaga cgaagttgaa   94860
gctccagaag gaattacttt tgaacttcca aacccaacaa caatcgttgt tagcggaatt   94920
tcaaaagaag tagttggtca aacagctgct tacgtacgta gccttcgttc accagaacca   94980
tataaaggta aaggtatccg ttacgttggt gaattcgttc gccgtaaaga aggtaaaaca   95040
ggtaaataat gttgagtggt tgatcatcaa ccaccaacct attttccaac tttgtgcata   95100
gcacacgatt taaaactaaa gaggtgaaaa ctgtgatttc aaaaccagat aaaaacaaac   95160
tccgccaaaa acgccaccgt cgcgttcgcg gaaaactctc tggaactgct gatcgcccac   95220
gtttgaacgt attccgttct aatacaggca tctacgctca agtgattgat gacgtagcgg   95280
gtgtaacgct cgcaagtgct tcaactcttg ataaagaagt ttcaaaagga actaaaactg   95340
aacaagccgt tgctgtcggt aaactcgttg cagaacgtgc aaacgctaaa ggtatttcag   95400
aagtggtgtt cgaccgcggt ggatatctat atcacggacg tgtgaaagct ttggctgatg   95460
cagctcgtga aaacggattg aaattctaat aggaggacac tagaaaatgg catttaaaga   95520
caatgcagtt gaattagaag aacgcgtagt tgctgtcaac cgtgttacaa aagttgttaa   95580
aggtggacgt cgtcttcgtt tcgcagctct tgttgttgtt ggtgaccaca atggtcgcgt   95640
aggatttggt actggtaaag ctcaagaagt tccagaagca atccgtaaag cagtagatga   95700
tgctaagaaa aacttgatcg aagttcctat ggttggaaca acaatcccac acgaagttct   95760
ttcagaattc ggtggagcta aagtattgtt gaaacctgct gtagaaggtt ctggagttgc   95820
cgctggtggt gcagttcgtg ccgttgtgga attggcaggt gtggcagata ttacatctaa   95880
atcacttggt tctaacactc caatcaacat tgttcgtgca actgttgaag gtttgaaaca   95940
attgaaacgc gctgaagaaa ttgctgccct tcgtggtatt tcagtttctg atttggcata   96000
agaaagggga taaaatggct caaattaaaa ttactttgac taagtctcca atcggacgca   96060
ttccatcaca acgtaaaact gttgtagcac ttggacttgg caaattgaac agctctgtta   96120
ttaaagaaga taacgctgct atccgtggta tgatcacagc agtatctcac ttagtaacag   96180
ttgaagaagt aaactaatga agttttaggg gatgtgcact gtaccatccc ctaaaactag   96240
atatagtcat ctatgatgac atcgtatagg cgagttgatg ggggagacaa ccttttctcc   96300
cttatcggcg ctagcatttt acaaaagagg agaaaataaa aatgaaactt catgaattga   96360
aacctgcaga aggttctcgt aaagtacgta accgcgttgg tcgtggtact tcatcaggta   96420
acggtaaaac atctggtcgt ggtcaaaaag gtcaaaaagc tcgtagcggt ggcggagttc   96480
gccttggttt tgaaggtgga caaactccat tgttccgtcg tcttccaaaa cgtggattca   96540
ctaacatcaa cgctaaagaa tacgcaattg tgaaccttga ccaattgaac gtctttgaag   96600
atggtgctga agtaactcca gttgttctta tcgaagcagg aattgttaaa gctgaaaagt   96660
caggtattaa aattcttggt aacggtgagt tgactaagaa attgactgtg aaagcagcta   96720
aattctctaa atcagctgaa gaagctatca ctgctaaagg tggttcagta gaagtcatct   96780
aagagaggtg acctatgttt tttaaattat taagagaagc tcttaaagtc aagcaggttc   96840
gatcaaaaat tttatttaca atttttatcg ttttggtctt tcgtatcgga actagcatta   96900
cagttcctgg tgtgaatgcc aatagcttga atgctttaag tggattatcc ttcttaaaca   96960
tgttgagctt ggtgtcgggg aatgccctaa aaaacttttc gatttttgcc ctaggagtta   97020
gtccctatat caccgcttct attgttgtcc aactcttgca aatggatatt ttacccaagt   97080
ttgtagagtg gggtaaacaa ggggaagtag gtcgaagaaa attgaatcaa gctactcgtt   97140
atattgctct agttctcgct tttgtgcaat ctatcgggat tacagctggt tttaatacct   97200
tggctggagc tcaattgatt aaaactgctt taactccaca agtttttctg acgattggta   97260
tcatcttaac agctggtagt atgattgtca cttggttggg tgagcaaatt acagataagg   97320
gatacggaaa cggtgtttcc atgattatct ttgccgggat tgtttcctca attccagaga   97380
tgattcaggg catctatgtg gactactttg tgaacgtccc aagtagccgt atcacttcat   97440
ctatcatttt cgtaatcatt ttgattatta ctgtattgtt gattatttac tttacaactt   97500
atgttcaaca agcagaatac aaaattccaa tccaatatac taaggttgca caaggtgctc   97560
catctagctc ttaccttccg ttaaaagtaa accctgctgg agttatccct gttatctttg   97620
ccagttcgat tactgcagcg cctgcggcta ttcttcagtt tttgagtgcc acaggtcatg   97680
attgggcttg ggtaagggta gcacaagaga tgttggcaac tacttctcca actggtattg   97740
ccatgtatgc tttgttgatt attctcttta cattcttcta tacgtttgta cagattaatc   97800
ctgaaaaagc agcagagagc ctacaaaaga gtggtgccta tatccatgga gttcgtcctg   97860
gtaaaggtac agaagaatat atgtctaaac ttcttcgtcg tcttgcaact gttggttccc   97920
tcttccttgg tgtgatttcc attttaccga ttgcagctaa agatgtattt ggtctttctg   97980
atgttgttgc ctttggtgga acaagtctct tgatcattat ctctacaggt atcgaaggaa   98040
tcaagcaatt ggaaggttac ctattgaaac gtaagtatgt tggtttcatg gacagaacag   98100
aataaaagta tttactgaat cagtaaatac tgagggagtg gaggtttaaa ctctgacatt   98160
tgtaagagtt ggatctcccc tcttctattt tgtttttaaa tcggggtgaa aagacttttt   98220
gcttctattt aaaaataaaa taaggagatc aaatcatgaa tcttttgatt atgggcttac   98280
ctggtgcagg taagggaact caagcagcaa aaatcgtaga acaattccat gttgcacata   98340
tctcaacagg tgatatgttc cgcgctgcaa tggcaaatca aactgaaatg ggtgttcttg   98400
ctaagtcata tattgacaag ggtgaattgg ttcctgacga agttacaaat ggaatcgtaa   98460
aagaacgcct ttcacaagat gatattaaag aaacaggatt cttattggat ggttacccac   98520
gtacaattga acaagctcat gccttggaca aaacattggc tgaacttggc attgaactag   98580
aaggtgttat caatattgaa gtgaaccctg acagcctttt ggaacgtttg agtgggcgta   98640
tcatccaccg cgtaactgga gaaactttcc acaaggtctt taacccacca gttgactata   98700
aagaagaaga ttactaccaa cgtgaagatg ataagcctga gacagtaaaa cgtcgtttgg   98760
atgttaatat tgctcaagga gaaccaatca ttgctcacta ccgtgccaaa ggtttggttc   98820
atgacatcga aggtaatcaa gatatcaatg atgtcttctc agatattgaa aaagtattga   98880
caaatttgaa ataaagcgtt tttcacactt gcaaaaatcc gctacaaatg ttatactgag   98940
atagtctgac ttataattgt tgtctctgtg tctagaggca tcgaatcgaa atttatggag   99000
gtgcttttgc gtggcaaaag acgatgtgat tgaagttgaa ggcaaagtag ttgatacaat   99060
gccgaatgca atgtttacgg ttgaacttga aaatggacat cagattttag caacagtttc   99120
tggtaaaatt cgtaaaaact atattcgtat tttagcggga gatcgtgtta ctgtcgaaat   99180
gagtccatat gacttgacac gtggacgtat cacttaccgc tttaaataat cgaaaaactt   99240
ggagggataa gaaatgaaag taagaccatc ggtcaaacca atttgcgaat actgtaaagt   99300
tattcgtcgt aatggtcgtg ttatggtaat ttgcccagca aatccaaaac acaaacaacg   99360
tcaaggataa gatagaaagg agaaaacatg gctcgtattg ctggagttga tattccaaat   99420
gacaaacgcg tagtaatctc attgacttat gtttatggta tcggacttgc aacatctaag   99480
aaaattttgg ctgctgctgg aatctcagaa gatgttcgtg tacgtgatct tacatcagat   99540
caagaagatg ctatccgtcg tgaagtggat gcaatcaaag ttgaaggtga ccttcgtcgt   99600
gaagtaaact tgaacatcaa acgtttgatg gaaatcggtt cataccgtgg tatccgtcac   99660
cgtcgtggac ttcctgtccg tggacaaaac actaaaaaca acgcccgcac tcgtaaaggt   99720
aaagctgttg cgattgctgg taagaaaaaa taatatagga ggtaaaagtc ttggctaaac   99780
caacacgtaa acgtcgtgtg aaaaagaata tcgaatctgg tattgctcat attcacgcta   99840
catttaataa cactattgtt atgattactg atgtgcatgg taatgcaatt gcttggtcat   99900
cagctggtgc tcttggtttc aaaggttctc gtaaatctac accattcgct gctcaaatgg   99960
cttctgaagc tgctgctaaa tctgcacaag aacacggtct taaatcagtt gaagttactg   100020
taaaaggtcc aggttctggt cgtgagtcag ctattcgtgc gcttgctgcc gctggtcttg   100080
aagtaacagc aattcgtgat gtgactccag tgccacacaa tggtgctcgt cctccaaaac   100140
gtcgccgtgt ataatcatcg cattacactg cttttcgttt aagagggagt aactaaatga   100200
tcgagtttga aaaaccaaat ataacaaaaa ttgatgaaaa taaagattat ggcaagtttg   100260
taatcgaacc acttgaacgt ggctacggta caactcttgg taactctctt cgtcgtgtac   100320
ttctagcttc tctaccagga gcagctgtga catctatcaa cattgatggt gtgttacatg   100380
agtttgacac agttccaggt gttcgtgaag acgtgatgca aatcattctg aacattaaag   100440
gaattgcagt gaaatcgtac gttgaagacg aaaaaatcat cgaactggat gttgaaggtc   100500
ctgctgaagt aacagctggt gacattttga cagatagcga tattgaaatt gtaaatccag   100560
atcattatct ctttacaatc ggtgaaggtt cttctctaaa agcgactatg actgttaaca   100620
gtggtcgtgg atatgtacct gctgatgaaa ataaaaagga taatgcacca gttggaacac   100680
ttgctgtaga ttctatttat acaccagtta caaaagtcaa ctatcaagtg gaacctgctc   100740
gtgtaggtag caatgatggt ttcgacaaat taacccttga aatcttgaca aatggaacaa   100800
ttattccaga agatgcttta gggctttcag cacgtatttt gacagaacat cttgatttgt   100860
ttacaaatct tactgagatt gctaagtcaa ctgaagtgat gaaagaagct gatactgaat   100920
ctgacgaccg tattttagat cgtacgattg aggaactgga cttgtctgtg cgttcataca   100980
actgtttaaa acgtgccggt atcaatactg tgcatgattt gacagaaaaa tctgaagcag   101040
agatgatgaa agtacgaaat cttggacgca agagtttgga agaagtgaaa ctcaaactca   101100
ttgatttggg tcttggatta aaagataaat aaaggaggaa tacatggctt accgtaaact   101160
aggacgcact agctcacaac gtaaagcaat gcttcgcgat ttgacaactg accttttgat   101220
caacgaatca atcgtgacaa ctgaagctcg tgctaaagaa atccgtaaaa ctgttgaaaa   101280
aatgattact ctaggtaaac gtggtgattt gcatgcacgt cgtcaagcag ctgctttcgt   101340
acgtaatgaa atcgcatctg aaaactatga tgaagcaact gataagtaca cttctactac   101400
agcacttcaa aaattgttct cagaaatcgc acctcgttat gctgaacgta acggtggata   101460
cactcgtatc cttaaaactg aatcacgtcg tggtgatgca gcgccaatgg cgatcatcga   101520
attagtataa aatcatcaat tttgttgagt gttatgatga tggagtcttg tgctcttagt   101580
ctagctctgg tctaccgcta ggatttcggt cctagcggga acactcatca taagttggga   101640
tagtagacgc ttgtttacga aattgttttt ttcttaagaa caacttcgta agcaggcgtt   101700
tttgagtatt ttcgttagaa ttatgctata ctatttgaaa agaatcctgt ttaatgttaa   101760
ggtttcttat tttaagaaga attggagttt acttatgaaa gccattataa ctgttgttgg   101820
taaagataaa tctggaattg ttgcaggtgt ttctggtaaa attgcagaat taggattgaa   101880
tattgacgat atctctcaaa ctgtcttgga tgaatatttt acgatgatgg ctgttgtatc   101940
tagtgatgaa aagcaagatt ttacctatct tcgtaatgaa tttgaagctt ttgggcaaac   102000
tttgaatgta aaaatcaata ttcagagtgc agcgattttc gaagctatgt ataatatcta   102060
ggaggtcatc atggatatta gacaagttac tgaaaccatc gccatgattg aggagcaaaa   102120
cttcgatatt agaaccatta ccatggggat ttctcttttg gactgtatcg atccagatat   102180
caatcgtgct gcggagaaaa tctatcaaaa aattacgaca aaggcggcta atttagtagc   102240
tgttggtgat gaaattgcgg ctgagttggg aattcctatc gttaataagc gtgtatcggt   102300
gacacctatt tctctgattg gggcagcgac agatgcgacg gactacgtgg ttctggcaaa   102360
agcgcttgat aaggctgcga aagagattgg tgtggacttt attggtggtt tttctgcctt   102420
agtacaaaaa ggttatcaaa agggagatga gattctcatc aattccattc ctcgcgcttt   102480
ggctgagacg gataaggtct gctcgtcagt caatatcggc tcaaccaagt ctggtattaa   102540
tatgacggct gtggcagata tgggacgaat tatcaaggaa acagcaaatc tttcagatat   102600
gggagtggcc aagttggttg tattcgctaa tgctgttgag gacaatccat ttatggcggg   102660
tgcctttcat ggtgttgggg aagcagatgt tatcatcaat gtcggagttt ctggtcctgg   102720
tgttgtgaaa cgtgctttgg aaaaagttcg tggacagagc tttgatgtag tagccgaaac   102780
agttaagaaa actgccttta aaatcactcg tatcggtcaa ttggttggtc aaatggccag   102840
tgagagactg ggtgtggagt ttggtattgt ggacttgagt ttggcaccaa cccctgcggt   102900
tggagactct gtggcacgtg tccttgagga aatggggcta gaaacagttg gcacgcatgg   102960
aacgacggct gccttggccc tcttgaacga ccaagttaaa aagggtggag tgatggcctg   103020
caaccaagtc ggtggtttat ctggtgcctt tatccctgtt tctgaggatg aaggaatgat   103080
tgctgcagtg caaaatggct ctcttaattt agaaaaacta gaagctatga cggctatctg   103140
ttctgttgga ttggatatga ttgccatccc agaagatacg cctgctgaaa ctattgcggc   103200
tatgattgcg gatgaagcag caatcggtgt tatcaacatg aaaacaacag ctgttcgtat   103260
cattcccaaa ggaaaagaag gcgatatgat tgagtttggt ggtctattag gaactgcacc   103320
cgttatgaag gttaatgggg cttcgtctgt cgacttcatc tctcgcggtg gacaaatccc   103380
agcaccaatt catagtttta aaaattaaga aaataggaga aattttaagt tctatttaag   103440
attagacgtg tatactataa tcattaaata aagacctcct aatattattt gaaacagata   103500
acactgaatt agtttgaatt tgattttcat ctaatatctt tatttaatga actcctaaac   103560
tttttcataa taatctcctt caaaagtcgc ctgtatgggt ggcttttatt ttatcattca   103620
tgatataata gaagcaaacg gaggacggaa aatggtaaaa gtacgattgt atttggtacg   103680
tcatggcaag accatgttta acacgattgg tcgcgcgcaa ggttggagcg atactccctt   103740
aactgctgaa ggtgaacgag ggattcaaga gttaggaatc ggtttgcgag aatctgatct   103800
acagtttgag cgtgcttatt cgagtgattc tggtcgtacc attcagacca tgggaattat   103860
ccttgaagaa cttggcttgc agggggaaat cccttatcgc atggacaagc gtatcagaga   103920
atggtgtttc ggtagttttg atggagccta tgatggcgat cttttcatgg gcattattcc   103980
tcgtatcttt aatgtggacc acgttcacca attgtcttat gctgaactgg ctgagggctt   104040
ggtagaggtc gatacagctg gttgggctga aggctgggaa aaactcagtg gccgaatcaa   104100
ggaaggcttt gaaatgattg caaaagaaat ggaagatcaa ggtggaggta acgcccttgt   104160
tgtcagccat ggaatgacta ttggaaccat tgtttatctg attaatggca tgcatccgca   104220
tggtctggat aatggtagcg tgacaatcct tgaatatgag gacggccagt ttagggttga   104280
agttgtcggt gaccgtagtt accgagagct aggacgtgag aagatggaag aaggctctat   104340
ttaatcagtc tagacttgct tgccatgagc tagggatttg ataagaatat caagataaga   104400
aaaaacagcc gagggcactc ctttcggctg tttttgatgt ggaaaactaa agtgtaatgc   104460
tattgctttt agagattttc ataaacaaga gcaaggaacc tactgttaga acagtcagga   104520
tagttgacaa ggttgcggct acaccgtaat ttcctctgag aacctctgta taaatagcta   104580
cagtcattgt tcttgttttg acattgtaga ggaggataga agtagagagt tttgaaatca   104640
ttgtgactca agataagatg gctccagaaa tgataccaga tagcatcatt ggagttgtaa   104700
tcttagcaaa ggtattgaga cgactacttc ctaagctttc agcagcttct tcaatacttg   104760
gtgctatttg ttgtaagcta gcaacagatg agcgaatagt ataaggtaat cttctggcag   104820
atagagacat aatcaagatg aaagcagtcc ctgtaatcat aagaaatcca cttccaaata   104880
gaccagtatt gaaggaagaa atgaaggcaa tccctagaac ggttcctggt acaatataag   104940
gtaccatact gaggctgtca attaagtttg taaacaaatt ccgttttcta acggctaggt   105000
aggagataaa tgtcgcaaat agaacaacta gaactaaggc aatcaaaggg atacgaatgg   105060
tattgaaaat agcagatccc atacgatgga aagctacctt gtaactgttt ggagaataac   105120
ctttaacaga taccatacct gatgttttta ggaaagaggt ataaattaag tagatttgag   105180
gtaaaacaga gataaagata attccgtaga ctgttgcata aatggcagcc atttttcctt   105240
ttgtagtttt tttaggctca attggatgga gcagattcat gctgaaactg tagcggtttg   105300
caatgtgttt ttggataagg aaaattgcca aggcaatgat aatcgccata attgcaaaag   105360
cagaatttcc tccaacctcg ctaataaatt gggtataaat caggacaggg aaagtccgat   105420
acccttcgcc aatcaacata ggcgttccaa agtctgagaa tgctctcata aatacaagca   105480
aggagctgct agtaaggttg gaactaggag aggtaaaaca accgttacga taggtttaaa   105540
tccgaaggac cccatgcttt cagctgcttc aagtagagaa ttgtcaatac tgttcattgt   105600
tccagcaaca tatagaaata ccagtgggaa tagttgcagt gtaaagacaa gtacaattcc   105660
tttgaatcaa taaatatcga tagctggaag ataaagggca tttgtcaaaa atttagtgat   105720
gacctcattt cgtcctagca agagaaccca ggagtaggct cctacgaaag gagctgacat   105780
ggaagcaatg ataatcaata tttgtagaaa tttcttcccc ttgaagtcat acatagagaa   105840
gagataagct aatagggttc ctacaactaa ggaagtgata gtagcggtaa tggaaacctt   105900
gaaactgttg actagtgtct cagagtagta ggctttacta aagaaagtga caaaattagc   105960
tagtgagaat tgtccttcat gtataagtgc ttgcttgagc acggtaacga taggataaac   106020
gagaaagata ggataggtaa gaaagaggaa gaaagaggaa actgtccaaa tatttagttt   106080
tttacgttcc atggttgact ccttttatca ggttttggga accatctgca gaaaagatgt   106140
ttaatttttg cgtattgatt cgtagacgaa tacgattgcc tttttgtaga tcttcttcaa   106200
aagttgattc ttcactaact tgaatttttg aggcaaaacc tgtctcaatg aaataatccg   106260
tatttagtcc aagatagacg ctatctctaa tagttccttc aatatctcca gattcatctt   106320
tgataaactc ttcgggacga atgcttacat gaatagcttg ctcctcaacc tgatcaagag   106380
ctggcattcg aagggcatag ccatctgaaa agacgatata agcgccgtcg ctccgttttt   106440
caagattggc agggataata tttgtgcgtc cgataaaggt tgccacaaac tcattagctg   106500
gtttatgata gagttctttt ggtcggccga tttgttggat caccccatct ttcataacag   106560
caatttggtc tgaaatagcc atggcttctt cttggtcgtg ggttacataa acagttgtaa   106620
ttcccacttc gtgttggatt tctcggatgg cttgacgcat atccaagcga agtttggcct   106680
ccagattact aagtggctcg tccatgagga gaacacttgg attaaccgct aaggcgcatg   106740
ccaaggtgac acgttgttgt tgtccaccac tgagtttatc gggctttcga tccgcatatt   106800
gagcaatttg catgagttca agatacttgt tggtctgttg aatcaattct tcttttggaa   106860
ccttcttttg cataagacca aaagcaacgt tgtctcggac agtcaaatgt gggaaaatag   106920
cgtagttttg gaaaaccatc ccgatattgc gtttgctggg ttccatatta ttgatttttg   106980
tatcatcgaa gtaaaattct ccaccttcga tactgttgaa acctgcaatc atacgaagaa   107040
gggtcgtttt cccacatcct gaagctccaa gaagggtaaa gagacttcct tttggaattg   107100
taatgttcaa attctcaata acagggacat cgtggtagat ttttttggcg ttaataattt   107160
tgatctcact catagtgaac ctcttttact gtttagattg gatatctgta aagacttcgt   107220
tgtatttctt aacgatatct gatttattct tgatgacata atcataatct tcagtgagtg   107280
ttttgatttt gtcaattggt ttcatgtttt cgcttgtttt agcattttta cgaacaggac   107340
ggttagtagt ggttgtacca agtgtatctt gtacttcttg agagataata aaatcgataa   107400
atttcttggc attttccata tttttagatt ttttaacgat agcagcacta gcaggtagga   107460
agacggttcc ttcttttgga tagactacct taatgttagc tccgtcattt aagagtttaa   107520
ctgctggatc ttcataagag agaccaacag ccatttctcc atcagcgact actttataga   107580
cactagatga acttgaaccg attttaccat caataagtgt gaaaagatct tttacataag   107640
accaagcctt atcatctttg taaccacctt gagcttgtag catatttgtt aattgagcaa   107700
aggcgctaga agagtttgct gggtcagcag ttgcgatttt tccttttagt tcaggtttga   107760
aaagatcgtt atatccttcg atgttcatgc ctttagttaa atcagggttg acgattaaaa   107820
cactaccatc tagtgtataa ggagtagagt agccagttgt gttttgatat tctttgataa   107880
cattatcatt ttcttttgaa gtatagtttt caaagagttc tccgtgggta gtatattgtg   107940
tataagaacc accaaagata acatcagcta caggaacttc tttttctgac tctagttttt   108000
tgaaaagttc tccagtacca gcttgaatca gttctacttt gataccatat ttttcttcaa   108060
aggcaggaat agttgctcca attaagccct ctgagtttgg tgaataaacg actagcgaac   108120
cgccgtctcc tttatcagat gaactgtcat cggcagattc attagaagaa caagcagcat   108180
aatacatcca tttctttttc atgatggata cctccgttgt gttatttaag tttattttaa   108240
aacaatgtaa gcgtttttaa aacatacaat tctattctat agtgtattga atctataaca   108300
gtacactttg actgctaaaa tatttctata aattaatttg actttcctga tagagatgtt   108360
cacatcttat ttcaattcac tatattagag taaaattctc tacaaaaaga agaatagcct   108420
attttactat tcttctgagt gatttcaatt cctttgggga aatatggaga tactttttaa   108480
atcctgacaa atggttgttt ctttttctaa atcggtgata ctgtatcgga gaatgcgcgt   108540
gaggtcacaa aggctgcgat agagcttcta tggagaattt ctttttggag agatttttta   108600
aaggaatgag acatccgcta cctccttgga aggttttttt gtgataagta tagcagttta   108660
aaaattctag agcaaggtaa aatagaaaag gtttggctaa aattttttag ctaaaccttt   108720
tgaaaagtta agtatgtatt atagatgctt gttatctgca aatagctaga gcatttcaag   108780
gaaataaact agaaataaca attaatatgg tggttcagaa ataccttttg ataatcaata   108840
agatcttcag gatgaagtgc gttgattcca tccatttcat atttccgatt taataaacga   108900
tatttgtttt caccaaattg atgaaaaggg agtagttgaa cttggtcgat atttaatgag   108960
ttaaatagag tagcgaattt ttctgcatcc tctaaactat tgttaaaatt aggaataact   109020
gggattctta aaacgatagt tttattttgt gaaaaagcat aatgaatgtt tttaataatc   109080
atttgattaa aaaccccagt cactttttta tgttttatag aattataatg ttttaggtct   109140
gtgtagataa aatccacata ttgaattaaa tcaataaatt tttcatgatc aacaaaggca   109200
gtagtttcaa tggcagtgtg tatgtgatgt tctttagctg attttaagat ggctttagca   109260
aattcaaact gagcaaatat ttcacctcct gataaagtta aacctccacc ggattcttcg   109320
taaaattctt tgtcttttaa tacctctgta ataatttctt ctacagtctt ttcttcaccg   109380
actaaggtga atttctctcg ttgagcatct ttcatttttt caggtttcat tctttgagat   109440
tcaggattag aacaccatgg acagcgcaga ggacatcctt ttaaaaaaac agttgtacga   109500
atacccggac cgtcatgaat tgaaaagtgt tgaatattaa aaataattcc tttagatatt   109560
tccataagag ttcctcctct tcataagtct atcctatcac aaaaacgaaa gaaaaacaat   109620
tacgaacgaa aggttaattt gttgtttttt gctttttatt ttggtagaat aaaacggagg   109680
tgtaaaatga aaagattgga acaaattatt aaattagtat cagaatatga aaagatcgac   109740
gttaatacat tatcggaaaa attaaatgta tcgaaagtaa cgattagaaa agatttagat   109800
aaattagagt caaaaggttt attacacaga gagcatggat atgctgtatt aaatagtgga   109860
gatgacttaa atgtacgttt gtcaattaat tatgaaacta agagaaaaat tgttcaggaa   109920
gcagtaaaat tggtgtcaga taatgaaaca ataatgatag aatctggatc gacctgtgct   109980
ttacttgctg aggaaatttg caagcaaaaa agaaatgtta cgattgtaac aaattcgttt   110040
tttatagcaa attttgtgag agcttatgat tcatgtcgtg ttattgttct tggtggtgag   110100
tttcagaaag attcacaggt gactgtagga cctttattaa aagaaatgat acagactttt   110160
catgtgtgtc aagcttttgt tgggacagat ggttacgata aagagatggg ctttaccgga   110220
aaagatttaa tgcgcagtga ggtagttcaa tatatttcag cagtgtcgga taaagtcatt   110280
gtcctaactg actcaagtaa atttgataaa agaggtacag taagaagatt tgctttaagt   110340
caagtctatg aagtaataac agacgaaaaa ctttctaaac aaaatatagc tacattagaa   110400
aatgctggga taatggttaa ggtagtttcg taagaggtta agtgtatgaa tcaagatagg   110460
aataaactgc tttctaaaat tgcttatctg tattatattg aaaacttaaa tcagtcacaa   110520
atagcagcaa aattaggaat ttatagaacc tctattagta gaatgttaac agaagcaagg   110580
aatgtaggaa ttgttaaaat tgaaatagag aattttgata ccaatatgtt taagttggaa   110640
aattatgtaa aagaaaaata cagtttggaa agtttagaaa ttattccaaa tgaatttgat   110700
gatactccaa caattttatc tgaaagaatt tctcaagttg cagcaggcgt ccttaggaat   110760
ctaattgatg ataatatgaa aattggcttt tcttggggga aaagtttaag taatttagta   110820
gatttaattc acagtaaaag tgtccgaaat gttcacttct atcctctagc aggtggtcct   110880
agtcacatac acgctaaata ccatgtgaat acactgattt atgaaatgtc tagaaaattt   110940
catggagagt gtacatttat gaatgcaacg attgtgcaag aaaataaatt gttagcagat   111000
ggtattttgc aatcaagata ttttgaaaat ttgaaaaata gttggaaaga tttagatata   111060
gctgtagtcg gaattggtga ttttagcaat aaagggaaac atcaatggtt agacatgctt   111120
acagaggatg actttaaaga attgaccaaa gttaaaactg taggagaaat ttgttgtcga   111180
ttttttgatt caaaaggtaa agaagtctat gaaaacttac aggaaagaac gatagcaatc   111240
tctttggaag atttaaaaaa tattcctcaa agtttagctg ttgcttacgg tgatacgaaa   111300
gtatcttcga ttctttctgt cttgcgtgct aatttagtaa atcatttgat tacagacaaa   111360
aatacaattt taaaagtttt ggaagaagat ggggatttga cttttagaga gattctaggt   111420
gagtgaaaat gatagactga ttcagtttat cgtttttctt tttagttgat tgcacatttg   111480
tgcttatata aacaaaaata gtttatctgt tgtttttgga ttgacaactt tattatgtag   111540
ttgtattcta tagttacaaa agaaaatttt aaaatttcaa atgaaaaaag ctttttacat   111600
agtgaaatga ggaggaattt atggaaatga ttgttccaga tcaaattatc atgggtttaa   111660
ttttatatgc tggtgatgcg aaacaacata tttataaagc gttagattac ataaaaaatg   111720
gtacatgtga acggtgtgaa gaagaaatac agttagctga tgcagcctta ttagaagctc   111780
ataatctaca aacaaaattt ttggcacagg aagcgtctgg tacaaagaca gaaattacag   111840
ctctctttgt tcattcacaa gatcatctca tgaccagtat gacggagatt aatttaatca   111900
aagaaattat tagtttgaga aaagaacttc ataaaaaata atactagagt attatcattg   111960
ttattaacat agaggaggaa aacataatgg tgaagattgg tttgttttgt gcagcaggtt   112020
tttctactgg tatgcttgta aataatatga aaattgcagc gcaatctagt ggagttgagg   112080
cagaaataga ggcgttttct cagtctaaat tagcggatta tgcgccaaat atagatgttg   112140
cactattggg tccacaagtt gcttatacat tagataaatc aaaagaaatt tgtgataagt   112200
gtgatgttcc gatagctgtt attccgatga tggactatgg tatgttagat gggaaaaaag   112260
tattagattt ggccctatct ttgattagtg ggtaagaaaa ggagatttat tatgtcaaag   112320
atggatgttc agaaaatcat tgcaccgatg atgaagtttg tgaatatgcg tggcattata   112380
gctctaaaag atgggatgtt agcaattttg ccattgacag tagttggtag tttgttcttg   112440
attatgggac aattgccgtt cgaaggatta aataagagca ttgctagtgt ttttggagct   112500
aattggacag agccgtttat gcaagtatat tcaggaactt ttgctattat gggtctaatt   112560
tcttgttttt caattgccta ttcttatgct aagaatagcg gagtagaggc tttaccagct   112620
ggagttctat ctgtatctgc attctttatt ttgctaagat catcttatat ccctaaacaa   112680
ggtgaggcga ttggggacgc tattagtaaa gtttggtttg gaggccaagg aattatcggt   112740
gctatcatta taggtttggt agtaggaagt atttatacct tctttataaa gagaaaaatt   112800
gttattaaga tgccagaaca agttccacaa gctattgcca aacagtttga agcaatgatt   112860
ccagcatttg taattttctt atcttctatg attgtatata ttttagcgaa gtcattgact   112920
aatggcggaa cattcataga aatgatttat tctgctattc aagttccgtt gcaaggttta   112980
actggatctt tgtatggtgc tattggaatt gcattcttta tatcattttt gtggtggttt   113040
ggtgttcatg ggcaatcggt agtaaatgga gtagtgacag ctctgctttt atctaatctt   113100
gatgctaata aagctatgtt agcctctgct aatctatcat tagaaaatgg tgcacatatt   113160
gttactcaac aatttttaga ttcattttta attctatcag gttcagggat tacgtttggt   113220
cttgtagttg ccatgctttt tgcagcaaaa tcaaaacaat accaagcctt aggaaaagtt   113280
gcagcttttc cagcaatatt taacgtaaat gagccagttg tatttggatt tccgattgtc   113340
atgaatccag ttatgtttgt acctttcatt cttgttcctg tacttgcagc tgtgatagta   113400
tatggagcta ttgcaacagg tttcatgcag ccattctcag gggtaacatt gccttggagt   113460
acaccagcta ttttatcagg atttttggtg ggtggatggc aaggagttat tactcagctg   113520
gtgatattag cgatgtctac attggtttat tttccattct ttaaagtaca ggatcgttta   113580
gcttaccaaa atgaaatcaa acaatcttag aggtatttgt gtgttactgt taaactcaca   113640
catttgtgct aaaaattaga gagttaaaat ttttctagtt aaaagcttga aaatttctat   113700
aaaaatcggt attatatttt cgaaagaaat aaaaatattt tcgaaagaaa ggtgcttacg   113760
atggtaaata cagaagtagc aagaacaaca atcaagacag aatattttgg cagccttact   113820
gaaaggatga acaaatatcg agaagatgtt ttaaataaaa aaccttatat tgatgctgag   113880
agagcagttc tagcaacacg cgcctatgaa cgatacaagg aacaacctaa tgtcctaaaa   113940
cgtgcatata tgctgaaaga aattttggaa aatatgacta tctatattga agaagaatct   114000
atgattgcgg gaaatcaagc ttcttccaat aaagatgctc ctatttttcc ggaatatacg   114060
ctagaatttg ttctcaatga gttggatctt tttgaaaagc gtgatggaga tgttttctat   114120
attacagaag aaacaaaaga acaacttaga agtattgctc cgttttggga aaataataat   114180
ttacgtgcta gagctggtgc cttattacct gaagaagtgt ctgtttatat ggaaacagga   114240
ttcttcggta tggaaggtaa gatgaattct ggagatgctc acttagcagt taactatcag   114300
aaacttttgc aatttggttt aagaggtttt gaagagcggg ctcgtaaagc aaaagtagct   114360
ctagatttaa cagatccagc aagtattgat aaatatcatt tttacgactc tatatttatc   114420
gtaatcgatg ctattaaagt atatgcaaag cgctttgttg ctcttgctaa aagtttagcc   114480
gaaaatgcaa atcctaaacg taagaaagaa ttacttgaga ttgcagatat ttgctctaga   114540
gtcccatatg aaccggcaac tacttttgca gaagctattc aatcagtttg gtttattcaa   114600
tgtattttac aaattgaatc taatggccac tctctttcat atggccgttt tgatcaatat   114660
atgtatccat atatgaaggc tgatttagaa agtggtaaag aaacagaaga tagcattgtt   114720
gaacgtctga caaatctttg gattaagaca attacaatta ataaggttcg cagtcaatca   114780
catacatttt cttcagcagg aagtccttta tatcaaaatg ttacaattgg tggacagact   114840
cgagataaga aggatgctgt taacccatta tcttatttgg tattaaaatc agttgcacaa   114900
acccatctac cgcaacctaa tctaactgta cgttaccatg caggtttaga tgctcgtttc   114960
atgaatgagt gtattgaagt gatgaaactt ggttttggta tgcctgcatt taataatgat   115020
gagattatta ttccttcttt tattgcaaaa ggagtattgg aagatgatgc ttatgattac   115080
agtgccattg gatgtgttga aacggcagtt ccagggaaat ggggctatcg ttgcacaggt   115140
atgagttata tgaacttccc taaggttcta cttatcacga tgaatgatgg aattgatccg   115200
gcttcgggta aacggtttgc accaagcttt ggtcgtttta aggatatgaa gaacttttct   115260
gaattagaaa atgcttggga taaaacacta agatatttga cacgaatgag tgttattgtt   115320
gaaaattcta ttgatttatc attggaacga gaagttcctg atattctatg ttcagcattg   115380
actgatgatt gtattggtcg tggaaaacac cttaaagaag gtggagcagt atatgattat   115440
atatcaggat tgcaagttgg aattgcaaat ttgtcggatt cattagctgc aattaaaaaa   115500
ttggtgtttg aggaagaacg tataagccca agtcagcttt ggcatgcact ggaaacagat   115560
tatgccggag aagaaggtaa ggtcattcaa gaaatgttga ttcatgatgc acctaagtat   115620
ggtaatgatg atgattatgc tgacaaattg gttactgctg cttatgacat ttatgttgat   115680
gaaattgcta aatatcctaa tacacgttat ggaagagggc ctattggagg aattcgttat   115740
tcaggaacat cttctatctc agccaacgta gggcagggac gtggaacatt agcaactcca   115800
gatggacgca acgcgggtac accgttagca gagggttgtt caccatcaca taatatggat   115860
caacacggcc ctacatctgt tttaaaatct gtttcaaaat taccaacaga tgaaatcgta   115920
ggtggggttc tcttaaatca gaaagtaaat cctcaaacgt tagccaaaga agaagataaa   115980
ttaaaactaa ttgctttgtt acgaacattc tttaatcgtt tacatgggta ccatattcaa   116040
tacaatgttg tttccagaga gacgctgatt gacgctcaga aacatcctga aaaacacaga   116100
gacttaattg ttcgtgttgc aggatactct gcattcttca atgttctttc taaggcaacc   116160
caagatgaca ttataggacg tactgagcat actttgtaaa ataaagaggt tctttttatg   116220
gaatttatgc ttgacacatt aaatttagat gagattaaaa agtggtctga aattttgccg   116280
ctagctgggg taacttcaaa tcccactatt gcaaaaagag agggttctat taattttttt   116340
gaacgaatca aagatgtaag agaattgatt ggctctacac cctctattca tgttcaggtg   116400
atttctcaag attttgaagg catcttaaag gatgctcata aaattcgaag acaagcagga   116460
gatgatatat ttatcaaagt acctgttact ccagctggat tacgtgcaat aaaggcgcta   116520
aaaaaagagg gctaccatat cactgcaaca gctatttata cagttattca gggattatta   116580
gctatcgaag caggagcgga ttacctagct ccatattata atagaatgga aaatctgaac   116640
attgattcaa attctgtcat tcgtcaatta gctcttgcta ttgatagaca gaactctcct   116700
agtaagattt tagctgcatc ctttaaaaat gtagcacaag taaataatgc tttagctgca   116760
ggtgcgcatg ctgttacagc aggagcggat gtttttgaat cagctttcgc catgccatct   116820
atccaaaagg cggttgatga tttttctgac gattggtttg ttattcaaaa tagtcgttcc   116880
atttagatag agaggaaata catatgagaa tttttgctag tccttctaga tatattcagg   116940
gggaaaatgc cttgtttgaa aatgccaaat caattttgga tttgggaaat tgccctattc   117000
tattatgcga tcagttggtt tatgatattg ttggaaaacg atttgaagat tacctacata   117060
ggtatggttt ccatattgtt ctggcgctat ttaatggtga agcttctgac aatgaaatca   117120
atcgagttgt tgccttggct gagaaagaaa attgtgatag tattatcggt cttggtgggg   117180
gaaagacgat tgatagcgca aaagctattg cagatttgat tgaaaagcct gttattattg   117240
ctccaacaat tgcatcgacc gacgcacctg tatctgcttt atctgttatt tatacagatg   117300
aaggtgcatt tgatcattat ctattttatt ctaaaaatcc agatttagtt ttggttgata   117360
caaaagttat ttcacaagcc cctaagcgtt tattagcgtc tggtattgca gatggtttag   117420
caacttgggt tgaggcgcgt gcggttatgc aggcaaatgg aaaaactatg ttgggacaac   117480
agcaaacatt ggctggagtt gcaattgcga agaaatgtga agaaacgctg tttgcagatg   117540
gtttacaggc tatggcagct tgtgaagcta aagtggtgac accagcatta gaaaatattg   117600
ttgaagctaa tactttattg agtggtctag gttttgaaag tggaggatta gctgcggcgc   117660
atgcaattca taatggtttt actgcattga caggtgacat tcatcattta acacatggtg   117720
aaaaagtagc ttatggaact ttagtacaac tattattgga aaatagacct aaagaagaac   117780
ttgataagta tattgagttt tacaaaaaaa ttggtatgcc aacaactcta aaagaaatgc   117840
atttggatca agttggatat gatgatttaa taaaagttgg taaacaagca actatggagg   117900
gtgagacaat tcatcagatg ccgtttaaga tttcgccttc agatgttgct caagctatta   117960
tcgctgtaga tgcctatgta aattcaaaat aaacaataag gactactgtt ttccaaatgg   118020
tagtctttta ttgatccctg tattgaattc tatagaagat tgaaatagga tgagaacaaa   118080
tcgattggga aagtaaaatt aatttctata aatgttttag caattgtttc gtactatttc   118140
agattcagtc tactatatgt tcttcataaa tcaaaaagcg acataggttg tcggctattt   118200
attgtgaata cattaattag cattccagtt ttatcttcgg tctaaaataa gtattttgtg   118260
ctatacgaga taagcttctt gacttactcc ttgatttact gcataacaat gggataaaaa   118320
gtgggagata gagcaattca tagtcatcaa aattaatgag atacagtata cagtttttcc   118380
tttaaacaca tttcaaattc cctcaaaaat ggtataatag taacatcaca aaattggaga   118440
gagaccatga gtttttacaa tcataaagaa attgagccta agtggcaggg ctactgggca   118500
gaacatcata catttaagac aggaacagat acatcaaaac ctaagtttta tgcgcttgat   118560
atgttccctt atccgtctgg agctggtctg cacgtaggac acccagaagg ttatactgca   118620
accgatatcc tcagtcgtta caaacgtgcg caaggctaca atgtccttca cccaatgggt   118680
tgggatgctt ttggtttgcc tgcagagcaa tacgctatgg atactggtaa tgacccagca   118740
gaatttacag cggaaaacat tgccaacttc aaacgtcaaa ttaatgcgct tggattttct   118800
tatgactggg atcgtgaagt caacacaaca gatccaaact actacaagtg gactcaatgg   118860
attttcacca agctttacga aaaaggcttg gcctatgaag ctgaagtgcc agtaaactgg   118920
gttgaggaat tgggaactgc cattgccaat gaagaagtgc ttcctgacgg aacttctgag   118980
cgtggaggct atccagttgt ccgcaaacca atgcgccaat ggatgctcaa aatcacggct   119040
tacgcagagc gcttgctcaa tgacttagat gaactagatt ggtcagagtc tatcaaggat   119100
atgcaacgca actggattgg taaatcaact ggtgccaatg taactttcaa agtaaaagga   119160
acagacaagg aatttacagt ctttactact cgtccggaca cacttttcgg tgcgactttc   119220
actgtcttgg ctcctgaaca tgaattagta gacgctatca caagttcaga gcaagcagaa   119280
gctgtagcag actataaaca ccaagccagc cttaagtctg acttggctcg tacagacctt   119340
gctaaagaaa aaacaggggt ttggactggt gcttatgcca tcaaccctgt caatggtaag   119400
gaaatgccaa tctggattgc agactatgtc cttgctagtt atggaacagg tgcggttatg   119460
gctgtgcctg cccacgacca acgtgactgg gaatttgcca aacaatttga ccttccaatc   119520
gtcgaagtac ttgaaggtgg aaatgtcgaa gaagctgcct acacagagga tggcctgcat   119580
gtcaattcag acttcctaga tggattgaac aaagaagacg ctattgccaa gattgtggct   119640
tggttggaag aaaaaggctg tggtcaggag aaggttacct accgtctccg cgactggctc   119700
tttagccgtc aacgttactg gggtgagcca attccaatca ttcattggga agatggaact   119760
tcaacagctg ttcctgaaac tgaattgccg cttgtcttgc ctgtaaccaa ggatatccgt   119820
ccttcaggta ctggtgaaag tccactagct aacttgacag attggcttga agtgactcgt   119880
gaagatggtg tcaaaggtcg tcgtgaaacc aacactatgc cacaatgggc tggttcaagc   119940
tggtactacc tccgctatat tgacccgcac aatactgaga aattggctga tgaggacctc   120000
ctcaaacaat ggttgccagt agatatctac gtgggtggtg cggaacatgc tgtacttcac   120060
ttgctttatg ctcgtttctg gcataaattc ctctatgacc tcggtgttgt tccgactaag   120120
gaaccattcc aaaaactctt taaccaaggg atgattttgg gaacaagcta ccgtgaccac   120180
cgtggtgctc ttgtggcaac cgacaaggtt gaaaaacgtg atggttcctt cttccatgta   120240
gaaacagggg aagagttgga gcaagcgcca gccaagatgt ctaaatcgct caagaacgtt   120300
gttaacccag acgatgtggt ggaacaatac ggtgccgata cccttcgtgt ttatgaaatg   120360
tttatgggac cactcgatgc ttcgattgct tggtcagaag aaggtttgga aggaagccgt   120420
aagttccttg accgagttta ccgtttgatt acaagtaaag aaatccttgc ggaaaacaat   120480
ggtgctcttg acaaggttta caacgaaaca gtcaaagctg ttactgagca aattgagtct   120540
ctcaaattca acacagctat tgcccaactt atggtctttg tcaatgctgc taacaaggaa   120600
gataagcttt atgttgacta tgccaaaggc tttattcaat tgattgcacc atttgcacct   120660
cacttggcag aagaactctg gcaaacagtc gcagaaacag gtgagtcaat ctcttatgta   120720
gcttggccaa cttgggacga aagcaaattg gttgaagatg aaattgaaat tgtcgtccaa   120780
atcaaaggaa aagttcgtgc caaactcatg gttgctaaag atctatcacg tgaagaatta   120840
caagaaatcg ctttagctga tgaaaaagtc aaagcagaaa ttgacggtaa ggaaatcgtg   120900
aaagtaattg cggtaccgaa taaactcgtt aatatcgtcg ttaaataacg agtttattag   120960
ctctatctgc caccttcaat agtccactgg actattgaag ccaactaaat tagttaacat   121020
tgttgtgaaa taagatagga gtccttcaga gtagaatctg gaggattttt tgaatcttct   121080
tatgaaagta tgatatacta tgggcaacta taaagtttga aaagtgaaat aaggagaata   121140
agatgccagt aaatgaatat ggtcaaatga ttggggagtc aatggaagct tatactccag   121200
gtgaattgcc ttcttttgat ttcttagaag ggcgttatgc taggatagag gctctttcag   121260
tggaaaagca tgcggaggat ttattagctg tttatggccc tgatacgcct cgggagatgt   121320
ggacctacct ctttcaggag tcagtagcag acatggagga actggtcagc cttttaaatc   121380
agatgttggc tcgtaaggac cgtttttatt atgcaatcat agacaaggca actggtaagg   121440
ctttgggaac tttttccctc atgcgaattg atcagaataa ccgagtaata gaagtgggag   121500
ctgtcacttt ttctccagag ctcaggggga cacggatagg aacagaagcc cagtatctct   121560
tggcttgcta tgtctttgag gagcttaact atcgtcgcta tgagtggaaa tgcgatgctc   121620
ttaacctgcc atccagacga gcagcggaac gtttgggatt tatttatgaa ggaaccttcc   121680
gtcaggcagt ggtttataag gggcgtacaa gagatacgga ttggttgtct atgattgata   121740
aggactggcc tcaagtcaaa gctcgattgg aaatatggtt gcgtcctgaa aactttgata   121800
aaaatggacg acagcacaag agcttgagag aactttaaga ggtgttgaga tgattactat   121860
taaaaagcaa gaaattgtca agctagagga tgttttgcat ctctatcagg ctgtcggttg   121920
gacaaactat acccatcaaa cagagatgct ggagcaggcc ttatctcatt cattagtaat   121980
ttatctggca cttgatggtg atgctgtggt gggcttgatt cgtttggttg gagatggttt   122040
ttcatcagtt tttgtacagg atttgattgt tttgcctagc tatcagcgtc aagggattgg   122100
tagctccttg atgaaagagg ctttaggaaa ttttaaagag gcctatcaag tccagctggc   122160
gacagaagag acagaaaaaa acgtgggatt ttatcgttct atgggctttg aaatcttatc   122220
cacctatgac tgtacaggaa tgatttggat aaacagagaa aaataaaaaa acttgtttgt   122280
tcttaagcaa agtttaagga tggtctagta tcatatagtc attaaataaa gacctcctaa   122340
ctttatttaa taaaatccta aacttttttc atcacaatct cctaatgaag ccacccaatc   122400
aggtggcttt tttgcggtac gacgggcatg tcgtatatct gaggtgtaag tcctcagcct   122460
gactatcgtg aggtagcagg gagaggaagg gatagcgaaa tcgtggctct acgaacagga   122520
acgtgatagt aaggcgtata tagcggataa ggaggcttca aactctaaag tccaaaaagg   122580
tagtcgtaac ctatatgtgt aaatcacgag agtaattgaa ttcggactaa ggtttgtgtg   122640
aaaaagataa atctttctag agtctaaaga ctctgcgtca gatttcctat tttcactgta   122700
accttttaac gtcctcatat cttgtataaa cgaggaaaga tgtacgactt atcccgtgag   122760
gtttcatgag cgctgaaagc gtagtaacaa cgaatcatga gaagtcagcc gagcccatag   122820
tagtgaggaa acttccgtaa tggaagtgga gcgaaggggt gaatactcaa acagtctggg   122880
gagagactgt ttgaggtctg tcgctagaaa gagaaaacga cagatcgaag taatcctact   122940
tcacttgtgt ctgtaaaatg agtggtctga tagaactgga ctttgacacg taatgactag   123000
atgaaggttc accaatataa gatgtccctc aggcaccaaa ataagaaagg aatacgcaca   123060
tgtcaaaact gctagataag atattatcac gcgaaaatat gctggaagcc tacaatcaag   123120
taaaatccaa taaaggctca gctgggattg atggaatgac tatcgaagag atggataatt   123180
atctcagaca aaactggcgc ttgactaagg aactgataaa acagagaaaa tataagcctc   123240
aaccagttct tagagttgag atacctaaac cagacggagg catccgtcaa ctaggaattc   123300
caacagttat ggatagaatg attcaacagg ccattgtcca agtcatgagc cccatttgtg   123360
aaccccattt ctcagatacg agttatggtt tcagaccaaa taggtcatgt gaaaaagcca   123420
tcatgaagct cttagaatac ttaaatgacg gctatgagtg gatagtggat tagacctaga   123480
gaaatttttc gatacagttc ctcaagatag attgatgtcc ttagtacata acattatcga   123540
agacggagat acggaatcct tgattcgtaa gtatcttcat tcaggtgtta tcattaatgg   123600
tcaacgttat aaaacactag ttggtacacc acagggagga aatttatctc ctctcttatc   123660
caatatcatg cttaatgaat tggacaagga attagaaaag aggggacttc gatttgtgcg   123720
ctacgcagat gattgtgtga ttacggtcgg aagcgaggca gcctctaagc gtgtgatgta   123780
ttcagtcagt cgttttattg agaaacggct aggtttgaaa gtaaacatga ccaagagagt   123840
tgaaatatct aggttttggg ttctggaaat tatcagatgg ttggaaaagc cgtccacatc   123900
aagatagtgt tcggagattt aagtttaaat tgaagaaact aacacagagg aaatggagta   123960
tagacctaac aagacgtatt gagcaactga atttgtctat tcgaggatgg ataaactatt   124020
gctcattggg aaatatgaaa agtatagtcg ccagcataga tgagcgcttg cgtactcgcc   124080
tacgagtgat tatctggaag caatggaaga agaaatcgag acgattatgg ggattgctta   124140
agttaggagt tcctaaatgg atagcagata aggtatctgg ctggggcgac cattatcaat   124200
tagtagctca gaagtcggta cttaaacgtg ctatatcaaa accagtcctg gaaaaacgtg   124260
gactggtttc gtgtttggat tattaccttg aacgacatgc gttaaaagtt agttgaaccg   124320
ccgtatgcca aacggcacgt acggtggtgt gagaggggct agagattatc ccctactcga   124380
ttggtgaggt gctggtgata gaaatttttt gcaaaatagt aaaattttag aaaagttaag   124440
ctagttttaa gtttcgtctt gtatcatgta gttattaaat aaagacctcc taactttatt   124500
taataaaatc ctaaactttt ctttttcata ataatctccc ttaactccac cgaatcaggt   124560
ggagtttttt agctctattt caggattttt gggactattc taaaaataat ttttcgatat   124620
ttttcggtat ttttcggatt ttggtcgggg aattggcggg gactttttga gattttggcg   124680
gggatttttt tagcgaatat gactaagaaa taggtctgtg gtcgcttcag ctagttcaaa   124740
ctcaatttga ttgtaagtga ctgttaattg aaggactgga actactgtaa taatgatttt   124800
gcttgtctag tagtggcgta ttaaatgaga agtgacatgt aagattgtct cttcgtttac   124860
gaaatcaaaa tttctatgaa attgatagaa tccctaacgt tctcttaatc ttaaccgtct   124920
tgtcgtacag cggttgaaga aaatgtaaag ttttgacaaa attcgtgaac tatgggataa   124980
taaaaaggaa ttgagtacta gttctatatc ataggctaga aaagacccca agctcacgac   125040
caaataagct tgaggtcttt tttgacacta tttgtccttg tttagccatt tatcgactat   125100
acgaagaacg acaccgacca caattggtcc gataatagtt ttgagtacta attccatcat   125160
gggctatctc acctcctttc gtaggcggtg tagaagtgcc gtataatatt ataccacata   125220
agtgctaaac ttaggagtca cccaatcagg tggctttttt gtttgtggct tgtttttttt   125280
gatataatag agccatgagt agaattttag ataatgagat gatgggtgat gaggagttag   125340
tagaacgcac gctccgtcct cagtatttac gtgaatatat tggtcaggat aaggttaagg   125400
atcaacttca gatctttatc gaagccgcta aaatgcggga tgaagcgctg gatcatgtgc   125460
tcttatttgg ccctccaggg cttgggaaaa caaccatggc ttttgtcatt gccaatgaac   125520
tgggagtcaa tctcaagcaa acgtctggtc ctgttatcga aaaagcgggt gatttggtag   125580
cgattttgaa tgatttagag cctggagatg tcctctttat tgacgagatt catcgcttac   125640
ccatgtcagt ggaagaagtg ctttatagtg ccatggagga cttctacatc gatattatga   125700
ttggggctgg tgaaggcagt cgcagtgttc atttggagtt gcctcctttt accttgattg   125760
gtgcgacgac tcgggctggt atgctctcaa atccactacg ggcacgtttt gggattacag   125820
gtcatatgga gtattatgct catgctgact tgacagaaat tgtcgagcgg acggcagata   125880
tttttgagat ggaaatcacc catgaggcag catctgagtt ggccctacgt agtcgtggaa   125940
cccctcgtat tgccaatcgt ctcctcaagc gcgtgcgcga ttttgcccag ataatgggga   126000
atggggttat cgatgatgtt attaccgata aggctttgac tatgctggat gttgaccatg   126060
aaggtttgga ctatgtggat caaaaaatcc ttcgcaccat gattgagatg tacagtggag   126120
gacctgttgg tctaggaact ctttctgtga atatcgccga agagcgtgag acagttgaag   126180
acatgtatga gccttacttg attcaaaaag gttttatcat gcggacacgg tctggacggg   126240
tggcgactgc taaggcatat gagcacttag gttatgaata cagtgaaaaa taagcaagaa   126300
atcttagagg cttttagaga aagtccagat atgatggcca ttctgacgat catccgagac   126360
cttggtttga aagactcgtg gttggcagca ggttctgtca gaaatttcat ctggaatctt   126420
ttgtcagaca aatccccttt tgatcatgaa acagatatag atgtgatttt ctttgatcca   126480
gatttttctt atgaggaaac cttattactg gagaaaaagc tgagagagga ttttcctcag   126540
taccagtggg aattgaaaaa tcaggtctat atgcatcagc acagtcctca cactgcttcc   126600
tataccagtt ctcgtgatgc tatgagtaag tatccagaac ggtgtacggc agttggactg   126660
cgcttgaatg aagaattaga ttttgaactc tatgtacctt atggtttgga ggatattttg   126720
aattttcaag ttcgtccaac tcctcatttc ttagaaaatg aagaccgaat ggaactctat   126780
caaacacgtt tatccaagaa aaattggcag gagaaatgga aaaatttgat ttttaaaaat   126840
acttaaggaa actttaagct agggagtgta cactaagttc ataagttaag aagaccttaa   126900
cttaaactcc taaaactttt tcataataat ctccctataa aaataaagtc gcccaatcag   126960
gcggcttatt tttttgaaaa atgggcttgg tgcctgagaa taaatagctt agtgatagaa   127020
gaaaatgggg aaatatggta taatgaaacg atagattttt gaataggaat aagatcatgt   127080
ttggattttt taagaaagat aaggctgtgg aagtagaggt tccgacacag gttcctgctc   127140
atatcggcat catcatggat ggcaatggcc gttgggctaa aaaacgtatg caaccgcgag   127200
tttttggaca taaggcgggc atggaagcat tgcaaaccgt gaccaaggca gccaacaaac   127260
tgggcgtcaa ggttattacg gtctatgctt tttctacgga aaactggacc cgtccagatc   127320
aggaagtcaa gtttatcatg aacttgccag tagagtttta tgataattat gtcccggaac   127380
tacatgcgaa taatgttaag attcaaatga ttggggagac agaccgcctg cctaagcaaa   127440
cctttgaagc tttaaccaag gctgaggaat tgactaagaa caacacagga ttgattctta   127500
attttgctct taactatggt ggacgtgctg agattacaca ggcgcttaag ttgatttccc   127560
aggatgtttt agatgccaaa atcaacccag gtgacatcac agaggaattg attggtaact   127620
atctctttac tcagcatttg cctaaggact tacgagaccc agacttgatt atccgtacta   127680
gtggagaatt acgtttgagc aatttccttc catggcaggg agcctatagt gagctttatt   127740
ttacggacac cttatggcct gattttgacg aagcggcctt gcaggaagct attcttgcct   127800
ataatcgtcg tcatcgccga tttggaggag tttaggagga aatatgaccc aggatttaca   127860
gaaaagaacc ttgtttgcag ggattgccct ggctattttc ctaccaattt taatgattgg   127920
gggcctcttg cttcagatag caatcggaat catagccatg ctagccatgc atgaactttt   127980
gaagatgaga ggtctagaga ccatgacgat ggagggcctc ttgaccctct ttgcaacctt   128040
tgcattgacc attcccttgg agaattacct gacttttttg ccagttgatg ggaatgtggt   128100
tgcctatagt gttttgattt caatcatgtt aggaacgacc gtttttagca agtcttatac   128160
gattgaggat gcggttttcc ctcttgctat gagcttctac gtgggctttg gatttaatgc   128220
tttactagat gctcgtgttg caggtttgga caaggctctc ttagccttgt gtatcgtctg   128280
ggcgacagac agtggtgcct atcttgttgg gatgaactat gggaaacgaa agttagcacc   128340
aagggtatcg cctaataaaa cccttgaggg tgccttgggt ggtattttag gagcaatttt   128400
agtaaccatt atccttatga tagttgacag tacagttgct cttccatatg gaatttacaa   128460
gatgtcagtc tttgctattt tctttagcat tgctggacaa tttggtgatt tactagaaag   128520
ttcgatcaaa cgtcattttg gtgttaagga ttctgggaaa tttatccctg gacatggtgg   128580
tgttttggat cgtttcgata gtatgttgct tgtatttcca atcatgcact tatttggact   128640
cttttaatca aaagacggag gaaacgctat gctcggaatt ttaaccttta ttctggtttt   128700
cgggattatt gtagtggtgc acgagttcgg tcacttctac tttgccaaga aatcagggat   128760
tttagtacgt gaatttgcca tcggtatggg acctaaaatt tttgctcaca ttggcaagga   128820
tggaacggcc tataccattc gaatcttgcc tctgggtggc tatgtccgca tggccggttg   128880
gggtgatgat acaactgaaa tcaagacagg aacgcctgtt agtttgacac ttgctgatga   128940
tggtaaggtt aaacgcatca atctctcagg taaaaaattg gatcaaacag ccctccctat   129000
gcaggtgacc cagtttgatt ttgaagacaa gctctttatc aaaggattgg ttctggaaga   129060
agaaaaaaca tttgcagtgg atcacgatgc aacggttgtg gaagcagatg gtactgaggt   129120
tcggattgca cctttagatg ttcaatatca aaatgcgact atctggggca aactgattac   129180
caattttgca ggtcctatga acaattttat cttaggtgtc gttgtttttt gggttttaat   129240
ctttatgcag ggtggtgtca gagatgttga taccaatcag ttccatatca tgccccaagg   129300
tgccttggcc aaggtaggag taccagaaat ggcacaaatt accaagattg gctcacatga   129360
ggttagcaac tgggaaagct tgatccaagc tgtggaaaca gaaaccaaag ataagacggc   129420
accgactttg gatgtgacta tttctgaaaa ggggagtgac aaacaagtca ctgttacacc   129480
caaagatagt caaggtcgtt accttctagg tgttcaaccg ggggttaagt cagattttct   129540
atccatgttt gtaggtggtt ttacaactgc tgctgactca gctctccgaa ttctctcagc   129600
tctgaaaaat ctgattttcc aaccagattt gaacaagttg ggtggacctg ttgctatctt   129660
taaggcaagt agtgatgctg ctaaaaatgg aattgaaaat atcttgtact tcttggcaat   129720
gatttccatc aatattggga tttttaatct tattccgatt ccagccttgg atggtggtaa   129780
gattgtgctc aatatcctag aagccatccg ccgcaaacca ttgaaacaag aaattgaaac   129840
ctatgtcacc ttggccggag tggtcatcat ggttgtcttg atgattgctg tgacttggaa   129900
tgacattatg cgactctttt ttagataatc gaggaatatt atgaaacaaa gtaaaatgcc   129960
tatcccaacg cttcgcgaaa tgccaagcga tgctcaagtt atcagccatg ctcttatgtt   130020
gcgtgctggt tatgttcgcc aagtttcagc aggtgtttat tcttatctac cacttgccaa   130080
ccgtgtgatt gaaaaagcta aaaacatcat gcgccaagaa ttcgaaaaga ttggtgctgt   130140
tgagatgttg gctccagccc ttcttagtgc agaattgtgg cgtgaatcag gtcgttacga   130200
aacctatggt gaagaccttt acaaactaaa aaaccgtgaa aaatcagact ttatcttagg   130260
tccaactcac gaagaaacct ttacagctat tgtccgtgat tctgttaaat cttacaagca   130320
attgccactc aacctttatc aaattcagcc caagtatcgt gatgaaaaac gcccgcgtaa   130380
tggacttctt cgtacacgtg agtttatcat gaaggatgct tatagtttcc acgctaacta   130440
tgatagtttg gatagtgttt atgatgagta caaagcagcc tatgagcgta ttttcactcg   130500
tagtggttta gacttcaagg ctattattgg tgacggtgga gccatgggtg gtaaggatag   130560
ccaagaattt atggccatta catctgctcg tacagacctt gaccgctggg ttgtcttgga   130620
caagtcagtt gcctcatttg acgaaattcc tgcagaagtg caagaagaaa tcaaggcaga   130680
attgctcaaa tggatagtct ctggtgaaga taccattgct tactcaagtg agtctagcta   130740
tgcagctaac ttagaaatgg caacaaacga gtacaaacca agcaaccgtg ttgtcgctga   130800
agaagaagtt actcgtgttg caacgccaga tgttaaatca attgatgaag ttgcagcctt   130860
cctcaatgtt ccagaagaac aaacgattaa aaccctcttc tacattgcag atggtgagct   130920
tgttgcagcc cttctagttg gaaatgacca actcaacgaa gtcaagttga aaaatcactt   130980
gggagcagat ttctttgacg ttgctagcga agaagaagtg gcgaatgttg ttcaagcagg   131040
atttggttca cttggaccag ttggtttgcc agagaatatt aaaattattg cagatcgtaa   131100
ggtacaagat gttcgcaatg cagttgtcgg tgctaacgaa gatgactacc acttgactgg   131160
tgtgaaccca ggccgtgatt ttactgcaga atatgtggat atccgtgaag ttcgtgaggg   131220
tgaaatttcc ccagatggac aaggtgtcct taactttgcg cgtggtattg agatcggtca   131280
tattttcaaa ctcggaactc gctattcagc aagcatggga gcagatgtct tggatgaaaa   131340
tggtcgtgct gtgccaatca tcatgggatg ttacggtatc ggtgtcagcc gtcttctttc   131400
agcagtgatg gagcaacacg ctcgcctctt tgttaacaaa acgccaaaag gtgaataccg   131460
ttacgcttgg ggaatcaatt tccctaaaga attggcacca tttgatgtgc atttgattac   131520
tgtcaatgtc aaggatgaag aagcgcaagc cttgacagaa aaacttgaag caagcttgat   131580
gggagctggt tatgaagtct tgacagatga ccgtaacgaa cgtgtcggtg ttaaatttag   131640
cgatagtgac ttgattggtc ttccaatccg tatcactgtt ggtaaaaaag cggccgatgg   131700
cattgtagaa gttaagatca aggcaactgg tgacaccatt gaggttcatg cagataacgt   131760
gcttgaaacg cttgaaatcc taagcaagaa ataaaaacta taatcagaag aaaaacaagg   131820
aaaaaatgta actagttttt accttgtttt ttctgtataa tgggagaaat gagtagataa   131880
agaggtaaat gtatgctaag atttccaaag gattttgtct ggggatcctc tacttctgga   131940
ccgcagacag aaggacgtgt agctggtgac ggtaagggag acaatctctg ggattactgg   132000
ttccaagtgg agccaaatcg ttactataat gggattggtt cagataagac atcgactttt   132060
tatgaaaatt gggagcggga tattgagctt ttgttagaga ctggtcacac agcctttcgg   132120
acttctattc agtggtcacg gatttttcca caaggctgtg gaaaagtcaa cactcaaggt   132180
gtggattttt atcgtaaggt ctttgaggct attaaggcta aaggaattcg tctgttagtc   132240
aatctctatc attttgattt accttttgcc cttcaagagg atggtgatgg ttgggaaaat   132300
aaggcgacag tctcagccta tgaagactat gctcgttttt gttttgagac ttatggagat   132360
ttagtggatc aatggattac ctttaacgag cccatcgttc ctgtagaatt tggttatttt   132420
tatgatgccc attatccaca taaggtggat gcagaggcag ctgttaaggt agcctatcat   132480
acacaattgg ccagcagccg ggctgttaag gcttgccatg aacttttgcc tgattccaag   132540
attgggattg tcctcaactt gacaccggct tatccacgta gccagcatcc tgctgatgtc   132600
aaggcagctc gtattgcggc cctttttcag gcccaatctt tcttagatcc atctgtcttg   132660
gggacttatc cacaggagtt ggtagaaatc ttgcatgaac acggtctttt acctgatgct   132720
acagaggaag agttggaact cattcgtgat aatacggtgg acttccttgg tgtgaactac   132780
tatcaacctt tgcgtgttat ggctcctcga tttgctaagc atccagagag tccactctta   132840
ccagaacatt tttacgagcc ttatgtgatg cctggacgta aaatcaattc tcaccgtggt   132900
tgggagattt atgagcaagg gatttatgac atcgcccaaa atatcaagga aaattatggc   132960
aatattgagt ggatgttgac tgagaatggt atgggtgttg aaggggaaga aaaattccgt   133020
caagatggaa tgattcaaga tgattaccgt attgactttg taaaaggtca tcttcgtgaa   133080
cttcaccgtg ccattgaaga tggtgccaac tgtaagggct acttgatttg gacctttatt   133140
gactgctggt catggctcaa cagctataaa aatcgctatg gtttggtcga attagacttg   133200
gaaacgcaag aacgtcgtct gaagaaatca ggccactggt tcaaagaatt aagcgataat   133260
aatggatttt aaaaaggact ctgactgatt atcccaatcg gtcagagttt ttatgcttac   133320
aggagcttaa tttgaactat accaattttt actcttgaca agtgaaagaa acaagtatat   133380
actgtttttg ctgattctat aaaagatgaa ttagactata ccaattttaa ggagaaagca   133440
cagcttgcct gtgtcgtata tactatgtgt ggaattgttg gtgttgttgg aaacacaaat   133500
gcaactgata ttttgattca agggcttgaa aagcttgaat accgtggcta tgattctgcg   133560
ggaatttttg tcctagatgg tgctgataac catttggtga aggcggttgg tcgtattgca   133620
gaattgtctg ccaagacagc tggtgttgag ggaacaactg gtatcggaca tactcgttgg   133680
gctactcacg gaaaaccaac tgaggacaat gctcacccac accgctctga gacggaacgt   133740
tttgtcttgg tgcataatgg ggtgattgag aactatcttg aaatcaagga agaatacctt   133800
gcaggtcacc acttcaaggg gcagacagat actgaaatag ccgttcattt gattggaaaa   133860
tttgcggaag aagaagggct ctcagttctt gaagccttca aaaaagccct tcacatcatc   133920
cgtggttctt atgcctttgc cttggttgac tcacaagatc ctgaagtcat ctacgtagct   133980
aaaaataaat caccactttt gattggtctt ggagaaggct ataacatggt ctgctcagac   134040
gccatggcta tgattcgtga aactaaccaa tacatggaaa tccatgacca agagttggta   134100
atcgtcaagg ctgatagtgt ggaagttcaa gactatgatg gaaatcgtcg tgagcgtgct   134160
agctacactg ctgaacttga cttgtcagat atcggtaagg gaacttaccc ttactacatg   134220
ctcaaggaaa ttgacgagca accaactgtt atgcggaaac tcatccaagc ctacacagat   134280
gaggctggtc aagttgtcgt agacccagat atcattaagg ctgttcaaga cgcagaccgc   134340
atctacatcc ttgcagctgg aacatcttac catgcaggat ttgcttctaa gaaaatgttg   134400
gaagaattga cagatacacc agttgaactt ggaatctcat ctgagtgggg ctacggtatg   134460
ccacttctca gcaagaaacc actcttcatc tttatcagcc aatctggtga aacagcggat   134520
agtcgtcaag ttttggtcaa ggctaatgaa atgggaattc caagcttaac agtgacaaac   134580
gttccaggtt caaccctctc acgtgaagcc aactatacca tgctccttca cgcaggtcct   134640
gaaattgccg tggcatcaac taaagcctat acagcgcaaa tcgcagccct tgccttcctt   134700
gcaaaagcag tcggagaagc aaatggtaat gctaaagcgc aagcctttga cctggttcat   134760
gaattgtcaa tcgtagctca gtctatcgaa tcaactcttt cagagaaaga aaccattgaa   134820
gtcaaggttc gtgaacttct tgaaacaact cgtaacgcct tttacatcgg acgtggtcaa   134880
gattactacg tagccatgga agcaagtctc aaactcaaag agatttctta tatccagtgt   134940
gaaggctttg ctgcaggaga actcaagcac ggaaccattg ccttgattga agaaggaacg   135000
cctgttttgg ctctcttgtc agatccagtt cttgccaatc atactcgtgg aaatatccaa   135060
gaggtcgcag cccgtggtgc caaagtcctc actatcgcag aagagaatgt agccaaagat   135120
accgacgata tcgtccttac gaccgtacat ccatacctct caccaatttc aatggtcgta   135180
ccaacgcaat tagtcgctta ctttgcaacc ctccaccgtg gcctcgatgt ggacaaacca   135240
cgtaaccttg ccaagtcagt aacggtagaa taagctaaaa aagtctagtt atctaggctt   135300
tttctaatga gcaaatcggt tgcttgtact caagattcgt gttagaataa tttttcaaat   135360
tgaagtacag agatagataa ggagaatcac aatggtagaa ttgggaattt caacatttgg   135420
ggaaataacg gagcttgaag ggactggaca aacttacagt catgctgaac gcattcgcca   135480
gttggtggca gagattgagc tggctgacaa ggttggtttg gatgtatatg ggattggtga   135540
gcaccatcgg gcggattttg cagtatcagc cccagagatt gttctggccg ctggggcagt   135600
caataccaag aaaatccgtt tgaccagtgc agtcagcatt ctgtcaagca tggacccgat   135660
tcgtttgttc caacagtatg ccactatcga tgctttgtca aatggacgat cggagattat   135720
ggctggaagg ggctctttca cggaatcttt ccctctgttt ggttatgact tgaaagacta   135780
cgactctctt tttgatgaga aattagactt gcttcagtta gtcaatgaaa agaccaagtt   135840
agactggcaa ggtcgattga ctcaaacgat tgctggtaaa gaagtttatc ctcgtccagt   135900
tcaggacaaa ttgcccttgt ggatagctac aggtggtcat gtcgaatcaa cagtgaagat   135960
tgctcaggct ggtctaccga ttgtatatgc tattattggt ggtaatccac gttattttaa   136020
aaagttgatt caggcttatc gtgagattgg aagcgaagcg ggccatgctg acaaagactt   136080
gaaagtggga gcccattctt gggggtggat tgcggaagat ggtgagcagg cggtgaaaga   136140
ttatttccat ccgactaagc aagtggtgga tgctatttcc aaagaccgtc cgcactggca   136200
ggaattgcgt tatgagcaat atttggagca ggtagggcca aatggcgcca tgtttgttgg   136260
caatccagat caggtggccg aaaaattgat tcgcatgata gaggatttag gattggaccg   136320
cttcatgctt catctaccgc ttggttctat gcctcatgac caggttctga gagctattga   136380
actcttcgga acacaagttg cacccaaagt acgagcttat tttgctatga aagaggctta   136440
ataaaaaatc ctaatcaagt ttattaggac aacaaatatt gtacaaaaat taatcccccg   136500
agctataatg cttgggggat ttttctatag gagggctagt ttagttctct tttttatttt   136560
ttagtaagaa accgagacca aggagcgcaa ggaggctgat tcctgcaaat aggagtttgt   136620
tttcgttttt gattcctgta tttggaagtt cagcttgttt atctggggtt gcaggtatat   136680
tttccttgct agagttttct accgattcgt ttcgaaccgc ttcttttaca gatgatgctt   136740
gtgcttcttg tgctggttgt tcagcttgtg aatcagctgt agcttggcta ggtttatttt   136800
ccgcatcagc tactttggca tctggtttag tagaatcagg tctagcttct ggagctgggt   136860
cttgatgtgc agggtgagaa gcttcatttt gatgttcagg cttggaaggg gttgagtctg   136920
gtttctcttc tgcagttgac tcatggctag ttccattttg agagactcga agaacagtag   136980
ctgtaagggc attcaatttc aagccttttt cagtccattc aagtcctttc gggttggcaa   137040
ttccgactgg tcctgcttgg ttttcatctg ccaaaacttc cgcatttctt agatgtgcaa   137100
aggcagttcc caaattaaat tcgcgagctt tttcatccgc attgacaaag actgcgtaga   137160
tatcgccgtt tggagcagtg atttggtagc caatcactac atcctctttt tccacaccat   137220
tttggcctgg gacagtgatg aggtggacac ggtctttgat atcttgaaga ctcttaagtc   137280
ggaaggcatc tgtagattga cgaagggcaa tcaaaccttt catatagtca cggctcttga   137340
cattttcagg ataagcttta ccatctgtag ccttagtcca gtcaaacttg ttgactgcat   137400
cactagaatc gtaagagtca tggatgaagt aaggatagtc aaatgggttg ccgtccttat   137460
cacgcaacaa gtgagatttg tttggaacct tatcctctgc tactggagtc ttgtaggctg   137520
ggtcacggaa ttgtttagta cgtccatatt cctgaccgga gtggataaat ggagttcctt   137580
gagctgtcaa gaccatgaga tttccaagtc gtaaacgacg gtggatttca gcatagttct   137640
cagccttgct tgggtctttt ttgatagact gggcaatgat gtcaaagagg gtcaagttat   137700
catgggctgc gatgtattgg atgacatctc cagggctgtc agcttcaaag ttagttggtt   137760
gagcaatgag atttttaaag atggtgttga catcacgctt gccacctgtg ataaaggcag   137820
gttgaccttc gtttggataa ccagatttga ggttgttacg gatgtcatct gaaaagacag   137880
cgacagtatc ggtatgtttc atccaatctt ggtcagcagc tttagtaggc atgttttcat   137940
caccggcata ggttctccaa ccttcaccaa gcatgatgag gtttggattg agggcgcgtg   138000
cagccttgta agcttcttcg atagaagcgg cgtcatggtc tcccatcata tcgaaacgga   138060
agccatccac tttgtaggta tcaactaggt atttgataga gtcaattagg agccgtttgg   138120
tcatatggtg ggttgtcccc aagcgtccac caccaaagct agttcgaggt gtgccatcgg   138180
catccataaa gtggtagtag tttggttcca aatcttcaaa gagatcgact ttggctgtgt   138240
ggttataaac gacatctagg atagctccca taccacgttt gtggatttcg ttgatgaggt   138300
ttttaaattc tgcgattcgt ttttctggat tcttaggatc gcttgagtac ataccagtca   138360
aggagaagta gttttgaggg tcatatcccc agttgtagtt gctgttgctt gaagcgtagt   138420
cagacaagcg ttcatggttt ttcaattcat tgacaaagta gtaagacaag actggaagga   138480
gctggatatg ggttacaccc aagtctttga gatagtctag tttttcaatg aaggcttcaa   138540
aagtcccaaa tggtttggtc aagtcttttg caatggcagg atctgaagtg aaatcacgca   138600
catgagcttc gtagataacg gcgtcttcac gagtcttgaa attgtgaatc ttaccataag   138660
tcaagtcttg aggtccgagt ttagctggat ctacaaaggc ggctttagcc actttatggg   138720
catcgtcaat cttggaatcg tcgctattcc aagcagcaag agatttagcg taaggatcga   138780
gtgcaagaac agttttacct tgacgctcga tttggtattg ataatagtag ccagtgaaat   138840
ctgtgattcc gagtttgttt gtgctgtcta gagtttgttt ccaagttcct ctttcccctt   138900
tttcaagagc gacagttcca actactttgt cagggtcatt cttgtcgtag acaacaacag   138960
aaaccttatc agcacttggt gaccaaaggg tcaaatcaac ttgttttcct tcttctttta   139020
ggtcagctcc cagtttgcca tcatagctgt atgtctcatc tttcaggcgc cagcttgttt   139080
tggtagtgaa ttggtcggaa ttgtagctaa cagtataagg atgttttgtg tcagagaaat   139140
ctccgctgta ggtcactttc ttaccagctt catcgattgc aacatcggta atagttacct   139200
tgtttcctag gtgattagtg atgttggagt gtttgaggat atcttctttt ttagcaccga   139260
caagtgttga aaagctactt tcaatgctag aagtgcctac gtgttgggct cctgtcatac   139320
ggatatcatg gacatagtat ggatttgtgt aaatcgattc atcatcgtct tttaggaaaa   139380
tttggctatg atttttcaaa tctgtgaact tataattttc tttacggatt ttcacgtcgt   139440
ctccttgttt gctctcatct agtaataaaa atccaaattc tcttgcggct tcattaagag   139500
gaatgtcgat atagcggcca tatttgcctg tagccgtaaa gtctgttccg tcaggccatt   139560
gagcgctact tggatttttc acatctcccc agtaccagag agatttcttg tcatagttgc   139620
catctgtgcg gtagtagttg acgcgaacag ttcctgcagg ctgtggctcg taagagaaaa   139680
ccttgtaatc ttggtctaac caagcttcgt tcatttttgg aactagtttt tctacagatt   139740
tatcgccggt tagatttttt ccagctgtat tgttgatgag gaagctaatt ttcttggctt   139800
gttctccctt taatttgaca tctaggtaat agccgtagtc atctttcttg gcatccttga   139860
aggacaaagc tccgtttggc cagttttcag atggtttttc aacatcgtcc caagtccata   139920
gtccttgagc atccttgttt tcttcaggaa gttttttgac atggatacgg aagtagttat   139980
cttcgatggg ctcttctgcc ttagtttcag ttgttactgg actagtagaa gtagttggct   140040
cacttgaacg atcttgtcca gtttgtggtg ctggatcggc tgggcttgca gcaggttttt   140100
cttctgtttt ctctagggaa gcgtttgcat ttccaggtga agaaatatca ctttcgttct   140160
taccagagcc agctgctgta tcagtaagag gttgggcaag ggtggttgta tttctgttgt   140220
tgggttcgtt agtggttggt gtactttcgt cggatgagat agttggtgta gccatggcaa   140280
gcaagacaag gcttgcgccg ataaggacag aaccagttcc atttttgagg gaacggatgc   140340
tgtagaccat ttttttctca gtgtgagatg gtgtttttct cataatgatt ctccaatcaa   140400
taaatttcta tatcagtata gcatgtagta aaacaatatg caagcgtttt ctttgatttg   140460
tgaaagaaat tcttactttt gagaagtttt ccgtactatt ttatatatca gtataaatga   140520
cggagataaa aatgtcacgt aagccaagcc gtgttattag gaagatgatg tgttctcagc   140580
tatttttatt cagaaattga tctctaacat taccaataaa aaagaaaaat atcttgacaa   140640
gcaagggaaa attttgttac aataatagac ggtacttttt acttttggtc tctcaagagt   140700
gtacagggac gtgctgacaa atgttgcaaa agtacacaca gatgatatct gtcaccaagt   140760
gtatcatcac caaaaataaa aaaacacagg agaatgtaga tgcctacaat taaccaattg   140820
gttcgcaaac cgcgtaaatc aaaagtagaa aaatctaaat caccagcttt gaacgttggt   140880
tacaatagtc ataaaaaagt tcaaacaaac gtttcttcac cacaaaaacg tggtgttgca   140940
actcgtgttg gaacaatgac acctaaaaaa cctaactcag cccttcgtaa attcgctcgt   141000
gtacgtttga gcaaccttat cgaagttact gcctacatcc caggtatcgg acacaacttg   141060
caagagcaca gcgtggtgct tcttcgcggt ggacgtgtaa aagaccttcc aggggtacgt   141120
taccatatcg tccgtggtgc acttgatact gcaggtgtta acgatcgtaa acaaggccgt   141180
tctaaatacg gtactaaacg tccaaaagca taaggaaagg ggataaagag aaatgagtcg   141240
taaaaataga gctccaaaac gtgacgtatt gccagatccg ctatacaatt cacaactagt   141300
tactcgtctt atcaaccgcg ttatgcttga tggtaaacgt ggtactgctg cttcaatcgt   141360
ttacggtgct tttgagcaaa tcaaagaagc tactggcaac gatgcacttg aagtatttga   141420
aacagctatg gaaaacatca tgcctgtact tgaagtacgt gcacgtcgtg ttggtggttc   141480
taactaccaa gtcccagtta aagttcgtcc agaacgtcgt acaacacttg gacttcgttg   141540
gttggtaaca atcgctcgtc ttcgtggtga acacacaatg caagaccgtc ttgcaaaaga   141600
aatcttggat gctgctaaca acactggtgc agcagttaag aaacgtgaag atactcaccg   141660
tatggctgaa gctaaccgtg cattcgcaca cttccgttgg taagatagga tgcgaaagcg   141720
ttaagaaagt cccagagaaa atagggaatc gaagcaggtt gcggttgcaa ccaatgagat   141780
tcatcttttt ctccagactt ttagcttgag ctcaactaaa tcatgatgct aggaacggta   141840
aggatgcaag gtaaaaatag gaaactgacg cagtattcga cgaatacaag gagttttatc   141900
tttttcacgc agcatcccgt tccagctcac atcggctaac taactttagc ccgggttcaa   141960
attagctaaa tcgattagta ttagctataa ctcagcttac catctcgtaa gttgaaacca   142020
acaatagcat gaaaacattg agaacgggta ggtcctgcct atccgttttt attaaaatcg   142080
tgttataata gaatagaaat caaaaataaa taggagaaac aaacctcatg gcacgcgaat   142140
tttcacttga aaaaactcgt aatatcggta tcatggctca cgtcgatgcc ggtaaaacaa   142200
caactactga gcgtattctt tactacactg gtaaaatcca caaaatcggt gaaactcacg   142260
aaggtgcgtc acaaatggac tggatggagc aagagcaaga acgtggtatc acgatcacat   142320
ctgctgcgac gacagctcaa tggaacaacc accgcgtaaa catcatcgac acaccaggac   142380
acgtggactt cacaatcgaa gtacaacgtt ctcttcgtgt attggatggt gcggttaccg   142440
ttcttgactc acaatcaggt gttgagcctc aaactgaaac agtttggcgt caagcaactg   142500
agtacggagt tccacgtatc gtatttgcca acaaaatgga caaaatcggt gctgacttcc   142560
tttactctgt aagcacactt cacgatcgtc ttcaagcaaa tgcacaccca atccaattgc   142620
caatcggttc tgaagatgac ttccgtggta tcattgactt gatcaagatg aaagctgaaa   142680
tctatactaa cgaccttggt acggatatcc ttgaagaaga catcccagct gaataccttg   142740
accaagctca agaataccgt gaaaaattga ttgaagcagt tgctgaaact gacgaagaat   142800
tgatgatgaa atacctcgaa ggtgaagaaa tcactaacga agaattgaaa gctggtatcc   142860
gtaaagcgac tatcaacgtt gaattcttcc cagtattgtg tggttcagcc ttcaaaaaca   142920
aaggtgttca attgatgctt gatgcggtta tcgactacct tccaagccca cttgacatcc   142980
cagcaatcaa aggtattaac ccagatacag acgctgaaga aattcgtcca gcatctgacg   143040
aagagccatt tgcagctctt gccttcaaga tcatgactga cccattcgta ggtcgtttga   143100
cattcttccg tgtttactca ggtgttcttc aatcaggttc atacgtattg aatacttcta   143160
aaggtaaacg tgaacgtatc ggacgtatcc ttcaaatgca cgctaacagc cgtcaagaaa   143220
tcgacactgt ttactcaggt gatatcgctg ctgccgttgg tttgaaagat actacaactg   143280
gtgactcatt gacagatgaa aaagctaaaa tcatccttga gtcaatcaac gttccagaac   143340
cagttatcca attgatggtt gagccaaaat ctaaagctga ccaagacaag atgggtatcg   143400
cccttcaaaa attggctgaa gaagatccaa cattccgcgt tgaaacaaac gttgaaactg   143460
gtgaaacagt tatctcaggt atgggtgaac ttcaccttga cgtccttgtt gatcgtatgc   143520
gtcgtgagtt caaagttgaa gcgaacgtag gtgctcctca agtatcttac cgtgaaacat   143580
tccgcgcttc tactcaagca cgtggattct tcaaacgtca gtctggtggt aaaggtcaat   143640
tcggtgatgt atggattgaa tttactccaa acgaagaagg taaaggattc gaattcgaaa   143700
acgcaatcgt cggtggtgtg gttcctcgtg aatttatccc agcggttgaa aaaggtttgg   143760
tagaatctat ggctaacggt gttcttgcag gttacccaat ggttgacgtt aaagctaagc   143820
tttatgatgg ttcatatcac gatgtcgact catctgaaac tgccttcaag attgcggctt   143880
cactttccct taaagaagct gctaaatcag cacaaccagc tatccttgaa ccaatgatgc   143940
ttgtaacaat cactgttcca gaagaaaacc ttggtgatgt tatgggtcac gtaactgctc   144000
gtcgtggacg tgtagatggt atggaagcac acggtaacag ccaaatcgtt cgtgcttacg   144060
ttccacttgc tgaaatgttc ggttacgcaa cagttcttcg ttctgcatct caaggacgtg   144120
gtacattcat gatggtattt gaccactacg aagatgtacc taagtcagta caagaagaaa   144180
ttattaagaa aaataaaggt gaagactaat ccgtcctcac tctagaagga agtcacttag   144240
tggcttcctt ttgtctttag aaaatacctc taaatatggt aaaatagtag aagaataatg   144300
tgaggaaaat gaatgtcaaa tagttttgaa attttgatga atcaattggg gatgcctgct   144360
gaaatgagac aggctcctgc tttagcacag gccaatattg agcgagttgt ggttcataaa   144420
attagtaagg tatgggagtt tcatttcgta ttttctaata ttttaccgat tgaaatcttt   144480
ttagaattaa agaaaggttt gagcgaagaa ttttctaaga caggcaataa agctgttttt   144540
gaaattaagg ctcggtctca agaattttca aatcagctct tgcagtccta ctatagggag   144600
gctttctctg aaggtccatg tgctagtcaa ggttttaagt ccctttatca aaatttgcaa   144660
gttcgtgctg agggtaatca gctatttatt gaaggatctg aagcgattga taaggaacat   144720
tttaagaaga atcatcttcc taatttagcc aaacaacttg aaaagtttgg ttttccaact   144780
tttaactgtc aagtcgagaa gaatgatgtc ctgacccaag agcaggaaga ggcctttcat   144840
gctgaaaatg agcagattgt tcaagctgcc aatgaggaag cgctccgtgc tatggaacaa   144900
ctggagcaga tggcacctcc tccagcggaa gagaaaccag cctttgattt tcaagcgaaa   144960
aaagctgcag ctaaacccaa gctggataag gcggagatta ctcctatgat cgaagtgacg   145020
acagaggaaa atcgtctggt atttgaaggg gttgtttttg atgtggagca aaaagtgact   145080
agaacaggtc gtgttttaat caactttaaa atgacggact atacttcaag tttttctatg   145140
caaaagtggg ttaaaaacga ggaagaggcc cagaagtttg acctcatcaa gaagaattct   145200
tggctccgag ttcgagggaa tgtggagatg aataacttca cacgcgattt gactatgaac   145260
gtacaggatc tgcaggaagt tgttcactat gagcggaagg atttgatgcc agaaggtgag   145320
cgtcgggttg agtttcatgc tcatactaac atgtcgacta tggatgcttt gccagaggtc   145380
gaagagattg ttgcaacagc tgctaagtgg ggacacaagg cggttgctat cacggaccat   145440
gggaatgtcc agtcctttcc acatggctat aaggcggcta agaaagcggg aatccagctg   145500
atctatggga tggaagccaa tatcgtggag gaccgtgtcc ctatcgtcta taacgaagtg   145560
gagatggact tgtcagaagc aacctacgtg gtctttgacg tggaaacgac gggactttca   145620
gctatctata atgacttgat tcaggttgcg gcttctaaga tgtacaaggg gaatgttatt   145680
gctgaatttg atgaatttat caatcctggg catcccttgt cagcctttac tacagagtta   145740
actggaatta cagatgatca tgtcaaaaat gccaaaccac tagaacaagt tttgcaagaa   145800
ttccaagaat tttgcaagga tacggtccta gttgcccaca atgctacctt tgacgttggc   145860
tttatgaatg ctaattatga gcggcatgat cttccaaaga ttagtcagcc agttattgat   145920
acgctggagt ttgctagaaa cctctatcct gagtataaac gccatggttt ggggcctttg   145980
accaagcgtt ttggtgtggc cttggaacat caccacatgg ccaactacga tgcggaagcg   146040
actggtcgtc tgcttttcat ctttatcaaa gaggtagcag aaaaacatgg tgtgaccgat   146100
ttagctagac tcaacattga tctaatcagt ccagattctt acaaaaaagc tcggatcaag   146160
catgcgacca tctatgtcaa gaatcaggta ggtctaaaaa atatctttaa gctggtttcc   146220
ttgtctaata ccaagtattt tgaaggagtg ccacggattc cgagaacggt tctagatgcc   146280
catcgagagg gcttgatttt aggttcagcc tgttcagagg gtgaagtttt tgacgtggtc   146340
gtttctcaag gtgtggatgc ggcggttgag gtggccaagt attatgattt tatcgaggtc   146400
atgccaccgg ctatctatgc acccttgatt gccaaagagc aggtcaagga tatggaggaa   146460
ctccagacca ttatcaagag tttgatagag gttggagacc gccttggcaa gcctgttctg   146520
gctacgggaa atgttcacta tatcgaaccg gaagaagaga tttatcgtga aattatcgtc   146580
cgtagtttgg gacagggtgc gatgattaat cgaactatcg gtcatggtga acatgcccaa   146640
ccagcaccac ttccaaaggc tcattttcga acgactaatg agatgttgga tgaatttgcc   146700
tttttgggag aggaactggc tcgtaaactg gttattgaaa acaccaatgc cttggcagaa   146760
atatttgaat ccgttgaagt cgttaagggt gacttgtata cgcctttcat cgacaaggct   146820
gaagaaacag ttgctgagtt gacctataag aaagcttttg agatttatgg aaatccgctg   146880
ccagatattg ttgatttgcg gattgaaaaa gaattaacat ccatactggg gaatggattt   146940
gctgtgattt atctggcatc gcagatgctg gtgcaacgtt ctaatgaacg gggttatttg   147000
gttggttctc gtgggtctgt cggatctagt ttcgttgcga ccatgattgg gattacggag   147060
gtcaatcctc tctctcctca ctatgtctgt ggtcagtgtc agtacagtga gtttatcaca   147120
gatggttcgt acggttcagg atttgatatg ccccataagg actgtccaaa ctgtggtcac   147180
aaactcagta aaaacggaca ggatattccg tttgagacct tccttggttt tgatggggat   147240
aaggttcctg atattgactt gaacttctcg ggagaagatc agcctagcgc ccacttggat   147300
gtgcgtgata tctttggtga agaatatgcc ttccgtgcgg gaacggttgg tacggtagct   147360
gccaagactg cctatggatt tgtcaaaggt tacgagcgag attatggcaa gttttatcgt   147420
gatgcagaag tagaacgcct cgctcaagga gcggcgggtg tcaagcggac aacaggccaa   147480
cacccggggg gaatcgttgt tattccgaac tacatggatg tctacgattt tacgcctgtc   147540
cagtatccag cagatgatgt cacggctgaa tggcagacca ctcactttaa cttccacgat   147600
atcgatgaga acgtcctcaa actcgatgta ctgggacatg atgatccgac tatgattcga   147660
aaacttcagg atttgtctgg tattgaccct aataaaattc ctatggatga cgaaggcgtg   147720
atggcactct tttctgggac tgatgtgcta ggggtaacac ctgaacaaat tggaacgcct   147780
acgggtatgt tggggattcc agagtttgga acaaatttcg tacgtggaat ggtagacgaa   147840
acccatccga caacctttgc ggaattgctt cagctgtctg gtctgtccca cggtactgat   147900
gtttggttgg ggaatgctca ggatctgatt aagcaaggaa tagcggacct atcgactgtt   147960
atcggttgtc gggacgacat catggtttac ctcatgcatg cgggtctgga acctaagatg   148020
gcctttacca ttatggaacg ggtacgtaag ggtttgtggc taaagatttc agaagaggag   148080
agaaatggct atatcgaagc aatgaaggct aataaggtgc cagagtggta tatcgaatcc   148140
tgtgggaaaa ttaagtacat gttccctaag gcccatgcgg cagcctacgt tatgatggcc   148200
ttgcgtgtag cttacttcaa ggttcaccat cctatttatt actactgtgc ttacttctcc   148260
attcgtgcta aggcttttga tatcaagacc atgggtgcgg gcttggaggt catcaagcgc   148320
agaatggaag aaatctctga aaaacggaag aacaatgaag cctctaatgt ggaaatcgat   148380
ctctatacaa ctcttgagat tgtcaatgag atgtgggaac gaggtttcaa gtttggtaaa   148440
ttagatctct actgtagtca ggcgacagag ttcctcatcg acggggatac ccttatccca   148500
ccatttgtag caatggatgg tctgggagag aacgttgcca agcaactggt gcgggcgcgt   148560
gaagagggag aattcctctc taaaacagaa ctacgcaagc gtggtggact ctcatcaacc   148620
ttggttgaaa agatggatga gatgggtatt cttggaaata tgccagagga taaccagttg   148680
agtttgtttg atgagttgtt ttaaaaaatt gcttaataat ctattaaaag aggctaacgt   148740
atatccaata gatttacatt agctttcttt tttgttaaaa tagtctatgg aaagagggtg   148800
agagtatgtc aaagatgagt ataagcatcc gtctggatag tgaggttaag gagcaggccc   148860
aacaggtgtt tagtaatctg ggaatggata tgacaacagc tattaatatt ttccttcgtc   148920
aggcaattca atatcaggga ttaccttttg atgttagact agacgaaaat cggaagttgc   148980
tccaagcgtt aacggattta gaccaaaatc gtaatatgag ccagtctttt gaatcagtct   149040
cagatttgat ggaggactta cgtgcttaag attcgttatc ataaacagtt taaaaaagat   149100
tttaagttgg ctatgaagcg tggtttgaag gcagaattat tagaagaagt tttgaatttt   149160
ctggttcaag aaaaagaaca tcctgccaga aatcgtgatc attcattgac ggcatccaag   149220
cattttcaag gagttcgtga atgccatacc cagccagatt ggcttttggt ttataaagta   149280
gacaagtcgg aattgatttt aaatttgctg aggacaggca gtcacagtga tttattttaa   149340
tctattttaa gggggttctc atgaaactaa gaatatttgc ggaagataag ccggctaaga   149400
aggtatttga atatcaatta gaacttgctg atcgtacaat tcttctatcg acagcactct   149460
tgtcaggtgc tattgcttta gcaggaatct tttctgcttt gaaagaaaaa taaaaataga   149520
aaagagaaaa cagaatggtt ttaccaaatt ttaaagaaaa tctagaaaaa tatgcgaaat   149580
tgttggttgc gaacggaatt aacgtgcaac ctggtcacac tttggctctc tctattgatg   149640
tggagcaacg tgaattggca catctaatcg tgaaagaagc ttatgccttg ggtgcgcatg   149700
aggtcatcgt tcagtggaca gatgatgtga ttaaccgtga gaaattcctc catgccccga   149760
tggagcgttt ggacaatgtg ccagaataca agattgctga gatgaactat ctcttggaga   149820
ataaggctag ccgtcttgga gttcgttcat ctgatccagg tgccttgaac ggagtggacg   149880
ctgacaagct ttcagcttct gctaaagcta tgggacttgc catgaagcct atgcgtatcg   149940
caactcaatc taacaaggtt agctggactg tagcagctgc agcaggactt gagtgggcta   150000
agaaagtctt cccaaatgct gcgagcgacg aagaagcagt tgatttcctt tgggaccaaa   150060
ttttcaaaac ttgccgtgtc tacgaagcag atcctgttaa ggcttgggag gaacatgcag   150120
ccattctcaa gagcaaggcc gatatgctta ataaggagca attttcagcc cttcactaca   150180
cagcgccagg aacagattta acacttggtt tgccaaagaa ccacgtttgg gaatcagctg   150240
gtgctgtcaa tgcacagggc gaagaattct tgccaaatat gccaacagaa gaggtcttca   150300
cagcgcctga cttccgtcgt gcagatggtt atgtcacttc tacaaaaccg cttagctaca   150360
acggaaatat cattgaaggc attaaggtga cctttaagga tggacaaatc gtagatatca   150420
ctgctgagaa gggtgatcag gttatgaaag accttgtctt tgaaaatgcg ggtgcgcgtg   150480
ccttgggtga atgtgccttg gtaccagatc caagtccaat ttctcagtca ggcattacct   150540
tctttaacac ccttttcgat gaaaatgcgt caaaccactt ggctatcggt gcagcctatg   150600
cgactagcgt tgttgatgga gcggagatga gcgaagagga gcttgaagct gcagggctta   150660
accgttcaga tgttcacgta gactttatga ttggttctaa ccaaatggat atcgatggta   150720
ttcgtgagga tggaacgcgg gtacctcttt tccgtaatgg gaattgggca aattaaggag   150780
ataatatgtt aggaagtatg ttcgttggtc tcctagtggg atttttagca ggtgctatga   150840
ccaatcgtgg agagcgaatg ggatgttttg gaaaaatgtt tctcggttgg atcggagcct   150900
ttctaggtca cttgctcttt ggaacttggg ggccagtttt atcaggaaca gctattatcc   150960
cagcgatttt aggagccatg attgttttag ctattttttg gagacgagga agttaatttc   151020
ctaaatctga tactcaatga aaatcaaaga gcaaactagg aaactagccg caggatgctc   151080
aaagcactgc tttgaggttg cagatagaac tgacgaagtc agctcaaaac actgttttga   151140
ggttgcagat agaactgacg aagtcagtaa catatatacg gcaaggcgac gttgacgcgg   151200
tttgaagaga tttttgaaga gtatgaaacg aaaaggaggt tggtcattgt actagcctcc   151260
ttttgatatg atataatagt tctatgagat tagataaatt tttagttgcc tgtgcggtgg   151320
gaagtcggac tgaggtcaaa aacttgctca aggctgggcg cgtgactgta aatggtaaaa   151380
aagaaaaatc agctaaattg cagattgatg aaaaaataga tgagattcgc tttgatgggc   151440
aagtgttgga gtatgaagag tttgtctact acatgatgaa caagcccaaa ggagttatct   151500
cagcgactga ggatcccaag cacagaaccg ttctggactt gttggatgac ttggcgcgga   151560
gtaaggaagt tttcccagta ggacgcttgg atattgacac gcatggtctt ttgctcttga   151620
ccaatgatgg tcagctggct catgttcttc tttcgcccaa gcgtcatgtg gacaagactt   151680
atctggcaca agtcaaggga atcatgaccc aagaagatgt ggagacattt gctgagggta   151740
ttcctctcaa agactttacc tgtcaacccg ctatactgga gcttgtatcc atagatacag   151800
aaaagaatca aagccaaatc cgtgtgacca ttgcagaagg gaagtttcat cagatcaagc   151860
gtatggtggg ctactgtggc aaggaagtgg tggacttgca acgattgact atgggaactt   151920
tagtattaga tgagaaccta gaacgagggg aatggcgtcg cttgaccaag gaagaattag   151980
aaattctccg cgctaatatt atttaattta gtttaatact caatgaaaat caaagagcaa   152040
actaggaaac tagccgcagg ctgtacttga gtacggcaag gcgacgttga cgtggtttga   152100
atttgatttt cgaagagtat aaattcgaaa aaggtgaggg acaatgtcct cgccttttat   152160
gttttttagt tgcttccttt gtgaaaagag ttataataga ctgtagaata aaaggaggaa   152220
tctatgaacg cgattcaaga atcatttact gataaactat ttgccaacta tgaagcaaat   152280
gtaaaatacc aagcgattga aaatgctgcc agccacaacg gaatttttgc agctctggaa   152340
cgtcgccaaa gccatgtaga caacacacct gttttctcat tggatttaac caaggacaag   152400
gtcactaacc agaaagcgtc tggtcgttgc tggatgtttg cggctctcaa caccttccgc   152460
cacaaactca tctcgcaata caaattggag aactttgagt tgtcacaagc ccacactttc   152520
ttctgggata agtatgagaa atcaaactgg ttcttggagc aagtcattgc gacttcagac   152580
caagaattga ctagccgcaa gttagcttct tactccaaac acctcaacaa gatggcggtc   152640
aatgggatat ggtcgtttcc ctctttgaaa aatacggtgt cgtgcctaag tcagtttatc   152700
ctgagtctgt ttcatctagc agcagtcgtg agctaaatgc gatccttaat aaattgcttc   152760
gtcaagatgc tcaaatcttg cgtgacttgc ttgtttctgg tgcagatcaa gcgactgttc   152820
aagctaagaa agaagacctc ttgcaagaaa tctttaactt tcttgctatg tcattaggac   152880
ttccaccacg caagtttgac tttgcttatc gcgataaaga taacaactac aaaagtgaaa   152940
aaggaatcac accacaagag ttttacaaga aatatgtcaa tcttccttta gaagactacg   153000
tttctgttat caatgctcca actgctgata aaccttacgg aaaatcttac acagttgaga   153060
tgttggggaa tgtggttggt agccgtgcag ttcgctacat caacgttcca atggagcgct   153120
tgaaagaatt ggcgattgcc caaatgcaag caggtgagac tgtttggttt ggttctgatg   153180
tcggccagct cagcaaccgt aaggctggca tccttgcgac agatgtttat gactttgaat   153240
caagcatgga cattaaactt actcaagaca aggctggacg tttggactat agtgaaagct   153300
tgatgaccca cgccatggtc ttgacaggtg ttgacttgga cgaaaatggt aaatcaacca   153360
agtggaaggt tgaaaactca tggggagaca aggtcggtac agatggttac tttgttgcct   153420
cagacgcttg gatggacgaa tacacatacc aaatcgttgt tcgtaaggaa ttgctgacag   153480
cagaagaaca agctgcctat ggagcagaac caatcgtact tgcaccatgg gatccaatgg   153540
gagccttggc tgaataaaag catagaaaaa aggaatcaga ttttagaacc tggttccttt   153600
ttagttgctt gattacatga tgtgaagaac atgtgccaca atacccactg cgaagagggc   153660
aaggataata gtgattggag atactttttt cttaagtaag tacatgcaaa gtaaagtaag   153720
gagtagtcct gataatccag gaatcaacat atccaagttt tgttggaaag tagtaacttt   153780
ttcaggagtt tgagacaatc cttgtcctac ttgtgcgaat gcttcttgga tacctttaga   153840
cccttctggc aatttatccc aatggatata agccttttca tctagttgaa ctttagaaac   153900
atcgaaagca aatttaatat ttacccagcg ttgaacaagg acagcaagaa tgaacatccc   153960
aaggatagaa gctcctttag tgatatcttg aaggatacca ccagacatat ctttagtgat   154020
ttctgatcca gccttgtatc caatctcttg aacataccac aagaatgaca tacgaatcaa   154080
gttccatgca acaaagaaga ggagtggccc caagatattg ccagtaaggg caagtgaagc   154140
accgagagat ccaaggattg ggcgtactgt aaaccagaat actgggtcac cgataccagc   154200
aagaggtccc atcataccga ttttaacccc ttggatagca gcgtcatcga tttccacacc   154260
gttagcacgt tcttcttcaa gcgcaagagt aacccccatg actggagcag ctacgtatgg   154320
atgagtgttg aagaactcaa ggtgacgctc aagagcagcg atttgatctt cttttttagt   154380
atagagtttt ttgatagctg gaatgagtgt ataagcccag cccaagtttt gcatccgttc   154440
aaagttccaa gacccttgta agaaggttga acgccaccaa acttttttac gatctgattt   154500
agttaattga agtttttcag tcatgatgtt ttcagtcctt tcttatctta gtagtcttct   154560
aggatatcgc cgattgggtc gttagaagtt gcggctcctc cgccaccatt tccaccagtt   154620
ttagaaaggt gaaggtagat aagagcgata gcaacgccga tagcaccgaa tccgattaga   154680
gtaatatctg acacagcagc gagaacgaaa ccaagagcga agaatggcca tacttcacga   154740
gttgccatca tgttgataac catggcgtaa ccaacggcaa cgaccatacc accaccgata   154800
gccataccat ctttgagcca gtctggcatg gcactaagga tactttgtac agtttcagtt   154860
ggtaccataa ggagaagagc tgcaggaagc gcgatacgaa gtccttggaa aagtagcgcg   154920
atgaaatgcg cacgctccac agcgccgaag tcaccttttt tagcggcagc atctgcagta   154980
tgaaccaaac caactgaaat tgtacgaaca atcattgtca agaaaagtcc agctacagca   155040
agagggatag caaccgcttg ggcaacaccg ataccagtct tggtaaagtc accaccaaga   155100
accatgataa tggcagcagc gacagaagca agtgcagcat caggagcgat agcagcaccg   155160
atatttgacc aaccaagggc aatcatttga agcgatccac cgaggataat ccctgcttcc   155220
aagtgacctg ttacaagccc aataagggta caggctacaa gtggttggtg aaattggaac   155280
tggtcgagga tgccttcaag acctgcaaag aaggctacaa cgactactaa aaccatagaa   155340
ataatagaca tgtttaaaat cctttcataa ataatggctt atttgacatt ggctttgtta   155400
atcaagtcaa acaaatcttt tttagaatca tttggtactt tacggacatc aaattcaaca   155460
cccaagtcac gcattttttc aaatgtagca acgtcttctt tgtccataga caaaacggta   155520
ttgaccaatg ttttacctgt tgagtgagcc atagaaccaa cattaagagt cttgattggc   155580
acgccgcctt cgatggcacg aagggcatct tgaggtgttt caaacaagat aagggcatgt   155640
gtttctccaa aacgtgggtc ttttgaaatc tcaatcagtt tttgaattgg aaccacgtta   155700
gccttgacat tacctggagc tgcttgttta atcaattctt tacgaaggtc gtctttagcc   155760
acgttatctg aagcaacgat gatacgattt gcttttgaat ctggagtcca agcagttgca   155820
acctgaccgt gaagtagacg tgtgtcaaga cgggcaagat tgattttcaa tttaccgtct   155880
ccgataacag ttccttctgg gatagcagtt tgggcaactg gagcagctgc agcgcttgca   155940
acttcttcga ctggatttag ctcttctgga agagctttga tgccatcttt ggcttcttta   156000
atgatattag cagcgacttt ttctacacct gcagcagcgt ccatgaggcg ctctgtgtag   156060
gcttgaatca acatcggtaa gttaagtcct gtgatgatgg caaacttacg ctcaggattt   156120
tctcccatca cgcgactagc ttggttaaat ggagaaccac tccaaaggtc agccaaaact   156180
agaacctcat cttctgcgtc aaatgcagca acagcgttat taaacttagc gtatagatca   156240
tcaggacctt catttggcat aaaggtcaca acttgaacct tttcttgttc accaaagatc   156300
atagatcctg actgatgaat acccgcagca aattcgccgt ggctcgcaat aatgattccg   156360
atactcatta ttgtcattcc tccttttttg ttttagtttt catttaagaa aactttaaga   156420
ctgtttaagt ataaaccgtt ttcataaaaa aagcaactat ttatcataaa aaattaaaaa   156480
atttttattt ttgtatgttg atatgttgag tttttgagga gtaatcttga attcttattt   156540
aaaatttaat ataaaaaagt tggaagaagc ttccaacttt taaaataggt ttctattaga   156600
ttagtgggtg aagtcgagta ccatacgtcc ttggatttgg cctttttcca tttcgtcgaa   156660
aatggcaaca gcatcttcta ctggacgttt ttgaacaact gggactacca gaccttctgc   156720
accaaattgg aaggcttctt ctaagtcttt acgagttccg acaagagaac cgatgacttg   156780
gattccatcg aggactgttt taacgatgct gagttccatc atttcagaag gaagaccaac   156840
agcgacgacg cgaccaccag cacgaatgga gtcaacagcc tggttgaagg caactttaga   156900
cacagcagtt acgacagctg aatgagctcc tccatcagtt ttttctttaa tgagtccagc   156960
tacatcttca acttcgaggc cgttaatcac aatgtcagcg cctacttctt ttgcaagggc   157020
aagtttgtca ttgttgatat cgactgcgat aacatgagca ttgaatactt ttttagcgta   157080
ttgaacagcg aggttaccaa gtccaccagc accgtaaaga acaacccatt ggcctggttc   157140
aacttttgct tctttgatag ctttataggt tgttactcca gcacatgtga tagaagaagc   157200
ttgggctgga tcaagtccgt caggaacttt gacagcatag tcagcagtta cgatacattg   157260
ttcagccata ccaccgtcta ctgagtagcc agcatttttc actgtacggc aaagggtttc   157320
gcgaccagtt gtacagtatt cgcaagtgcc acatccttca aagaaccaag caacgctgac   157380
gcggtcaccg actttaaggc ttttcacatc tggagcaatc tctttaacga taccgatacc   157440
ttcgtgccca agaacacgtc ctgggacttg accaaagtca ccatgagcaa cgtggaggtc   157500
ggtgtggcaa acgccacagt attcaacttc tacaagtgct tccccagttt caagtggacg   157560
gagtactttt tcttcaatag caacaccagt gctttctgga tttacaacaa cagctttcat   157620
agctatcctc cttgatattg accgagaaca gggacaacgg gactggattg attttttgtc   157680
aacagagtcg agtgtgacga gctctcttgt atttatatgt gaagtatatc acaaaagaaa   157740
gccttttcca aggttttgga gacaaaaagt agaacaatcg attaactggt tgatgagact   157800
gtgaaaagag cacaaagacc agcttgcaag ctggtcatac tcttcgaaaa tctcttcaaa   157860
ccacgtcagc ttcatctaca acctcaaagc agtgctttga gcaacctacg gctagcttcc   157920
taagtttgct ctttgattct cattgagtat cagtataggt tataagaata agtcttgtag   157980
ggttttggca accccatctt ggtcgttggt aagggaaatt tgctcatctg cataagggag   158040
tagctctgga ttggcatttt tcatggcata acccttccca gcaaaagcga gcatttcggt   158100
atcattgtgt tcatctccaa aggcaatcaa atcttttttg tcacgattca ttatcttgag   158160
caagtagtcc aaagcaaagg ccttgttgac accttttggg gtacattcaa ggatattgag   158220
cggacctccc caggtattga tagaaagttg atgctggtag aaggcgttca tttcttttgc   158280
caaggaatat ttgtcactgg ctctagtctg caagaggata cagttagggt ccttggtcac   158340
caattcaggc tggaattgat cttcaggctg gaaagcttct acaccaaata gtttgggatt   158400
ggcaatttct tcattgggat ttgtaatgta gaatttttta cgatattctc cagcgataaa   158460
atcggcttga atgtcctctg aacgttgaac catatctagc agatattttt tgtctacagt   158520
caaacacttt tcaaaatccc aaacttggtc tggtaaatga gtaagggatc cgttgaagtt   158580
aatcatagga gtgtctaagc ccagttcacg gtaaaaatct tttgacatac ggtaagggcg   158640
acctgtcgta ataataacct gatggccttt ttcagcaact tttttgatgg ttcttttggt   158700
aaagtcagaa atttgactgt ctgagttgag cagggttcca tccaggtcaa ctgcaataat   158760
ttttttcgtc atatggacct ttctagtgtg ttttcagata agatgtcttc tattataaca   158820
gaaagcaggc agaaaagcag attccaaaca aaaaatgaaa ttggattaat ttcttaaaca   158880
aatcaaacaa agacattgaa aaagtgaatg ataaatgata taattctatt attgttcgta   158940
aaaattaaaa ggagattgat gatggacaaa ttatttaaac taaaagagaa cggtacagac   159000
gttcgtacag aggttctcgc tggtttaaca actttctttg caatgagcta tattctcttt   159060
gtaaacccac aaatactttc acaaacagga atgcctgctc agggcgtctt cctagcgacg   159120
attattggtg cagtagcggg taccttgatg atggcttttt atgctaactt accttatgcc   159180
caagcgccag gtatgggact caatgccttc tttaccttta cagttgtatt cgggcttggt   159240
tattcttggc aagaagccct agctatggtc ttcatctgtg ggattatttc attgattatt   159300
accttgacaa atgttcgtaa aatgatcatt gaatcgattc ccaatgctct tcgctcagct   159360
atttcagctg gtatcggtgt cttccttgcc tatgtaggga ttaagaatgc tggacttttg   159420
aaattcacga ttgatccagg caactatact gttgtaggag aaggggctga caaagctcaa   159480
gcaacgattg cagcaaactc ttcagcagtt ccaggattgg tcagctttaa taatccagct   159540
gttttagtgg ctcttgcagg acttgccatt actatcttct ttgtcatcaa agggattaaa   159600
gggggaatta ttctctctat cttgacaaca actgttcttg ctattgcagt tggtttggtt   159660
gatttgtcta gtatcgattt tgctaataac catgttggtg cagcttttga agatttgaag   159720
acaatctttg gtgcagctct tggttcagaa ggattgggag ctttggtttc agatacagct   159780
cgcttgcctg aaactctgat ggccattctt gccttctcat tgacagatat ttttgacaca   159840
attggtacct tgatcggtac aggtgaaaaa gttggtatcg tagcgacaaa tggtgaaaat   159900
caccaatcag ccaaattgga taaggctctt tactctgatt tgattggaac gacagtcggt   159960
gccattgcag gtacttcaaa cgtaacgact tatgttgagt ctgctgctgg tatcggtgca   160020
ggtggacgta ctggtttgac agccttggtt gtagctatct gttttgcgat ttcaagcttc   160080
tttagcccac ttctagcgat cgtaccaaca gcggctacag ctccaatctt gattatcgtt   160140
gggattatga tgcttggtag cttgaaaaat atccattggg atgatatgtc tgaagcagtt   160200
cctgccttct tcacatctat ctttatggga ttcagctact ctatcactca agggattgca   160260
gttggtttct tgacttacac tttgactaag cttgttaaag gtcaagttaa agatgttcat   160320
gtcatgattt ggattttgga tgccttgttt atccttaact acatcagcat ggccttataa   160380
tagaatgacc cagggggatt tccccccttt tttaatacaa aggagatagg tgatgaaaga   160440
gaaaaatatg tggaaagaat tgttgaatcg tgcaggctgg attttggtct ttttacttgc   160500
cgtcctttta tatcaggttc ccctagtggt tacctctatt ttgactttaa aagaagtagc   160560
cctgctacag tcagggctga tagttgctgg cctttcaatt gtggttctgg ctctatttat   160620
tatgggagct cgtaaaacca agttagctag ttttaatttt tcttttttta gagctaaaga   160680
tttggcacgt ttgggcttga gttatctagt tattgtcggg tcaaatatac ttggttccat   160740
tttattgcaa ctgtcaaatg agacgacaac agctaaccag tctcagatta atgatatggt   160800
tcaaaatagt tcgttgattt ccagtttctt cttgctagcc ttgcttgctc cgatttgtga   160860
ggaaatcttg tgtcgtggga ttgttcctaa aaagattttc cgaggcaagg agaacttggg   160920
atttgtagtc ggtacgattg tgtttgcttt attgcatcaa ccaagtaatt taccttcttt   160980
attgatttat ggaggtatgt cgacagttct atcttggaca gcctacaaga cccaacgttt   161040
ggaaatgtcg atcttgcttc acatgattgt taatgggatt gctttctgtt tgttggctct   161100
tgtggtgatt atgagtcgga cattaggaat ttctgtttaa aagtttttat gtaggaaccg   161160
acctctttct accagggaaa gatgaatgca atcgtgtcca tctttttctt tttatggtaa   161220
aatagaaaaa taatatgatg aaaatccttg agggagtgac cgatatgtca agtaaagcca   161280
atcatgcaaa gacagttatt tgcggaatta tcaatgtaac cccagactcc ttttcggacg   161340
gtggtcaatt ttttgctctt gagcaggcgc tccagcaggc tcgtaaattg atagcagaag   161400
gagccagtat gctagatatc ggcggagaat cgactcggcc gggaagtagc tatgttgaga   161460
tagaagagga aatccagcgt gttgttccag tgatcaaagc gattcgcaag gaaagtgatg   161520
tcctcatctc tattgatact tggaagagtc aagtagcaga ggctgctttg gctgctggtg   161580
ccgatctagt caatgatatc actggtctta tgggtgatga gaaaatggct tatgtggtag   161640
ctgaagcgag agcgaaagtg gtcatcatgt ttaacccagt tatggctcga cctcagcatc   161700
ctagttcgct tatcttccct cattttggtt ttggtcaaac ctttacagaa aaagagttag   161760
ctgactttga aacattgcca atcgaagact tgatggtggc tttctttgaa cgagcactag   161820
cgagagcggc agaagctggt attgcaccag aaaatatcct gttggatcca ggaattggct   161880
ttggtctgac caagaaagaa aatctgcttc ttttacggga cctggataaa ctacatcaga   161940
agggctatcc aatctttctc ggagtgtcgc gcaagcgatt tgtcatcaat atcctagagg   162000
agaatggttt tgaagtcaat cctgagacag agcttggttt ccgaaatcgg gacacggctt   162060
cggctcatgt aactagtatc gctgcgagac agggtgtaga agtggtgcgc gtgcatgacg   162120
tagctagtca caggatggca gttgaaattg cctctgccat tcgtctggct gatgaagcgg   162180
aaaatttaga tttaaaacaa tataaataag atgaaagaaa ttgaaaacaa tcagtggatt   162240
gctaactacc ggacggatca accgcatttt ggcttggaac gaatggtgga actgttagct   162300
ttgcgtggca atccccatct caaactcaag gtcctccata tcggagggac taacggcaag   162360
ggctcgacta ttgctttttt gaaaaagatg ctagaaaagc tagggttgag agttggcgtg   162420
tttagctcgc cctatctcat tcattacaca gaccagatta gcatcaatgg ggaatcgatc   162480
tcagaagcga ggctagaagc tctcatggca gactatcagt ctttgctgga gggagaagcg   162540
gtcgccaatt tacagggcac aaccgagttt gagattatca cagccctggc ctatgactac   162600
tttgcctcag agcaagtaga tgtggccatc atggaagttg gcatgggtgg acttttggat   162660
agtaccaatg tctgtcagcc cattttgaca ggaattacaa ctattggctt ggatcatgtg   162720
gctctacttg gtgacacctt ggaggtcata gcagagcaga aggcaggtat tatcaaacaa   162780
gggatgccct tggtaacagg gcgtattgct ccagaagcct tggctgtgat tgaccgcatt   162840
gcggaaggga aagatgcgcc gagacttgcc tacgggacag attatcaggt tcgtcatcaa   162900
gaaagtgtgg tgacagggga agtctttgac tatacaagtg ctgtcagaca aggtcgcttc   162960
cagactagcc tgcttggttt gtaccaaata gagaatgctg ggatggccat agctttactt   163020
gatacttttt gtcaagaaga tggtcgagag ctagcaagca atgattttct tggtcaagcc   163080
ttggaagaaa caagttggcc agggcgtttg gaaatcgtgt caagagatcc cttgatgatt   163140
ttggatggag cccacaatcc ccatgctatc aaggccttgt tggtaacctt gcaagaacgt   163200
tttgcggatt atcataagga aatcctcttc acttgtatca aaaccaaggc cttggaggat   163260
atgttggact tgctgggagc catgccagtt accgagctta ctctaacaca ttttgcggat   163320
agtcgggcga cggatgaaaa cgtgctgaaa gaggcagcta agtctagaaa tctcagctac   163380
caagattggc atgattttct agagcagaat ttgacagata aaaaagaaga gaaacaaaca   163440
gttaggattg tcacaggttc cttgtatttc ttgagccaag tgagggccta tctgatggag   163500
aggaagaacg agaatggata cacaaaagat tgaagcggct gtaaaaatga ttatcgaggc   163560
tgtaggagag gacgctaatc gcgagggctt gcaggaaaca cctgctcgtg tagcccgtat   163620
gtatcaagag attttttcag gtcttggtca aacagcagag gaacatttgt caaaatcctt   163680
tgaaattatt gacgataata tggtggtaga aaaggatatc tttttccata ccatgtgtga   163740
acaccacttc ttgccatttt atggtagagc gcacattgcc tacattccag atggtcgtgt   163800
ggcaggcttg tctaagctag cccgtacggt tgaagtttat tcgaaaaaac cacaaattca   163860
agaacgtttg aatatcgaag tggccgatgc cttgatggac tatctaggtg ctaaaggagc   163920
ctttgttgtc attgaggcgg aacatatgtg tatgagtatg cgtggtgtta gaaaaccagg   163980
cactgcaacc ttgacgacag tagctcgtgg tctatttgaa acagataagg atctccgtga   164040
ccaagcttat cgtttaatgg ggctataaaa agaatccgct tcaagcggat ttttctagaa   164100
aggaatcatt atggatcaac tgcagattaa ggatttggaa atgtttgcct atcatggtct   164160
ttttcctagt gagaaagaat tggggcagaa atttgtcgtt tcagccatcc tatcctatga   164220
tatgaccaag gcagctacag acttggattt aacagcctct gtccattacg gagaattgtg   164280
tcagcagtgg acgacttggt ttcaggaaac gagtgaagat ttgattgaaa cggtagccta   164340
taaactggtg gaacgtacct ttgagtttta tcctcttgtc caagaaatga agttggaact   164400
gaaaaaacct tgggcaccgg tgcatttgtc actagatact tgctcggtaa ccattcatcg   164460
ccgcaagcaa cgagccttta tcgccctagg aagcaatatg ggagataaac aagcaaactt   164520
gaagcaagcc attgacaaac tgcgagctcg tggcatccat attctcaaag agtccagtgt   164580
cttagcgacg gagccttggg gtggagtgga gcaggatagc tttgccaatc aagtggttga   164640
ggtggaaacc tggctaccag cacaagactt gttagaaacc ttgttagcca ttgagtcaga   164700
gctgggacgg gtgagagaag tgcattgggg acctcgtttg attgatttgg acttgctctt   164760
tgtggaggac cagatccttt atacagacga cctcatattg cctcatcctt acatagcgga   164820
acgccttttt gtccttgagt ccttacagga aattgcgcct cattttatcc atccgatatt   164880
aaaacaaccg atccgcaact tgtatgatgc tttgaaaaaa tagaaaaact ctagttttca   164940
gttacttgca actgaaggct agagttttta tactcttcga aaatctcttc aaaccacgtc   165000
agcgtcgcct taccgtactc aagtacagct tgcggctagc ttcctagttt gctctttgat   165060
tttcattgag tattaaaata ggtcattttc ttctgggagg aggatagttt ctctaccgtc   165120
catgtctaaa accagtactc ttgggggata acgagggtcg aaaggatggt taaagtcaaa   165180
atcaatggct gtagggaggt gttgacttga aaagtggaag gtaatctttc cttggttatt   165240
aagcaattga aactcgagtt cttcttccaa ttcaaagaca ttttttaaga aatggtcgat   165300
gatataccaa aaagagtcaa tgatgtcatc aggcaagctg gtaacaatac caaaactagc   165360
agatcgcatg tgggtattgg taaaagccat atctctgtcc cctttctttt cccttatcat   165420
acagcaaata ggattaaaaa tcaagaaaag gtgatttttt gaaaaggatt ttagttacag   165480
ggagaaatag ggaaaaaatt cctaaaaatc taccgaagtt aataggtaaa ttcccaaatt   165540
aacttgatta tataactttc agttactttg agaagttacc gaaaaatatt tttcatatct   165600
attgactttt aggggtaaaa tttggtatga tagtaggcgg tattgtttac cccatttgaa   165660
aggccccgga accttccaaa tacttttcga tgggaaggaa cacccatcac cgtaaacaaa   165720
aatcgaacta tatataggag aaatcatgaa caaaacaaca tttatggcta aaccaggcca   165780
agttgaacgt aaatggtacg tagttgacgc aactgatgta ccacttggac gtctttctgc   165840
agtagttgct agcgtacttc gcggaaaaaa caaaccaaca tttacaccac acactgatac   165900
aggtgacttc gtgattgtta tcaatgctga aaaagttaaa ttgactggta aaaaagcaac   165960
tgataaaatc tactacactc actcaaacca cccaggtgga ttgaaacaaa tctctgcagg   166020
tgaacttcgt tctaaaaatg cagtacgttt gattgagaaa tcagttaaag gtatgcttcc   166080
acacaataca cttggacgcg ctcaaggtat gaagttgaaa gtatttgttg gagctgagca   166140
cactcacgct gcacaacaac cagaagttct tgacatttca ggacttatct aaggaaagga   166200
acaataaagt atgtcacaag cacaatatgc aggtactgga cgtcgtaaaa acgctgttgc   166260
acgcgttcgc cttgttccag gaactggtaa aatcactgtt aacaaaaaag atgttgaaga   166320
gtacatccca cacgctgacc ttcgtcttgt catcaaccaa ccattcgcag ttacttcaac   166380
tgtaggttca tacgacgttt tcgttaacgt tataggtggt ggatacgctg gtcaatcagg   166440
agctatccgt cacggtatcg ctcgtgccct tcttcaagta gacccagact tccgcgattc   166500
attgaaacgc gcaggacttc ttacacgtga ctcacgtaaa gttgaacgta agaaaccagg   166560
tcttaagaaa gctcgtaaag catcacaatt tagtaaacgt taattcgaaa gaattactat   166620
acttatacag agcacctttc ggggtgttct ttttttatac tttcttacta aattggtgca   166680
attgacacag ttgttgcgac tttagtcgct tacaaatgtg gctgcaacct gacatggtca   166740
gttgcctcaa aacgttaatc aatacgatta tatcaacgtt tcaaagcact caagggttta   166800
ccctatgggt gcttttttct atactttcta aaaaagttta ccctaaaatt tgccctaaaa   166860
ttaccctact tatttttaag atgttggtag gcaacttgtc cagcagataa tggaactatg   166920
tttgaagtat taacataagt cttagttgta acggtatcgc tatgagttaa tgcttcagaa   166980
atggcttcta agctcattcc tgctttttta gcaagtgtcg ctcctgtatg tcgtaattta   167040
tgcggtgtag cgtgtgtcag ttctttatgt cggctttcta atgcttttca ttttattgtt   167100
cagatagtcg gcatgtaaag gcttgttgat gtttcctttt gtgtcgatat atgtaaaaac   167160
aaattgttct ggattactga ggatgccaaa ctttgctagt tcatatcttt gttgtttttc   167220
ccaagaggta agaagttgaa gtaaatcatt agaaatagag aaaaatagga tagcaaaagc   167280
tctatttcag gagaaaatga agcaaatatt tccataataa aacgcatatt atcaaggttg   167340
ttcaatacct gatactatgc gcttttctga ttttaaagac tgattgctca gtctcttttt   167400
cattataatt cagttacaat ttaatcttat ttgagaaagt gggtgatgct attctctaat   167460
aagactatga tattaatttt tgatagtact tccagaaatt atagatcccc tttcatcccc   167520
aatttctatt ttcaagtgtc cgtattatat agcgtattcg aaattcacta tatcttgtta   167580
ggatttgggt agaatcattg ataacagact gttgcaaatc taattagctg tatgatttat   167640
atttatctat ttttctagta accaatctat aatgcttttc ttctcgattc cattgtaatt   167700
ggctgttggc tgaatcgtat ccattgttaa tagatattta gggaattgat ctttaatggc   167760
ttctagtggt ctaagttctc tttctagtgt ttctggagca agtgttgttt cactgacctg   167820
ataataagcg tagtggccaa gatcagttac aacaacaaaa tcaacctcat acttatctaa   167880
attaccaaca tatacttgtg aatatctacg tctcaattcc aaatatacca tattttccaa   167940
gatatgccta atgtcttctt tctggtctgg taataagaga tgtcgtaaac ctaaatcaac   168000
gggataatat ttttctaaac gttgcaataa tgctctacct tttacatcaa aacgtggaac   168060
ggaataaaaa agtaaactat ctgtcaaagt tgtcaaataa ttttccaaag tattatggga   168120
tattgaaaca ttttggctga ctagggtatt gcgaatctta tttgttgata ttaagctacc   168180
tgtactactg agaagggttc ggacaatgcg ctcaataata gtaggatttg gttttcccaa   168240
tctagtgaca atatcattta acagtatgga gttatatatt cctctgagat agtcaatttt   168300
ttcatcgtaa gatgatgttt gcaataagta agggaaagca ctaaagagat aattgttaaa   168360
aatttctgtt gtattcagat tctctgtgag agattgacct gatagatatt cttcaaatga   168420
caaaggaaga acctctatct caacataccg accagtcaag tttgttgcta attggctact   168480
cataaagtag gcgttagatc cagtcaaata gaggtctaca tttgctaaga tgaatagact   168540
atctgctacc agttcaaatt tttcaacata ttgaatttca tctaaaaaga tatagtatgt   168600
tttcttgcta actaattgat cttttatata agcgaataat gtttgaaaat gtcgcagatc   168660
atagtaactc aaatcttcga aattgatgaa tataatctga tcctcgtcta ccccagttgc   168720
tagtaactcc tctttataga gttgaaaaag cacagattta ccagctcgtc taactccact   168780
cacaactttg atgattggtc ggtcacgatg ttttcttaaa aaatctaaat aatgtggtct   168840
tttgatatag ttcataatag ttacctcaaa gatagtataa tacaaataga tgttattttc   168900
aaatatttag aaataatatt taatttgttt tattatttct aagtgtttag aaatatagta   168960
aaatgaacca aaaatagtac acaatgtggt ataatcttct tatggcatat tcaatagatt   169020
ttcgtaaaaa agttctctct tattgtgagc gaacaggtag tataacagaa gcatcacacg   169080
ttttccaaat ctcacgtaat accatttatg gctggttaaa gctaaaagag aaaacaggag   169140
agctaaacca ccaagtaaaa ggaacaaaac caagaaaagt tgatagagat agacttaaaa   169200
actatcttac tgacaatcca gatgcttatt tgactgaaat agcttctgaa tttggctgtc   169260
atccaactac catccactat gcgctcaaag ctatgggcta cactcgaaaa aaagaaccac   169320
acctactatg aacaagaccc agaaaaagta gccttatttc ttaagaattt taatagttta   169380
aagcacctaa cacctgttta gattgacgaa acaggattcg atacttattt ttatcgagaa   169440
tatggtcgct cattaaaagg tcagttaata agaggcaaag tatctggaag aagatatcag   169500
aggatttctt tggttgcagg tctaacaaat ggtgagttaa tcgctccaat gacttacgaa   169560
gagacgatga cgagcgactt ttttgaagct tggtttcaga agtttctctt accaacatta   169620
accacaccat cggttattat tatggataat gcaagattcc atagaatggg gaagctagaa   169680
ctcttgtgtg aagagtttgg gtataaactt ttacctcttc ctccctactc acctgagtac   169740
aatcctattg agaaaacatg ggctcatatc aaaaagcacc tcaaaaaggt attaccaagt   169800
tgcaatacct tttatgaggc tcttttgtcc tgctcttgtt tcaattgact ataaatcgct   169860
ataagaaaaa atcattttat tggtataaag aagtgattga aagtaatggc gaaacgttag   169920
ataattagtt cataaaaaac aagtttagat cctcatctaa acttgttttt ttaaaattga   169980
aggatgattt tggaggatat aagatgacat tgactattca tgtatattat aaaggtgatg   170040
gagatagtgc aataaagttt gcaagagaaa tgcttgatag tggccttgtt aaagaaatta   170100
gaaatcaaaa aggtaacttg aaatacgaat attttttacc aattgaaaaa gagggaacta   170160
ttctccttat tgatcagtgg ataaatcaag aaactttaga taaacattat caatcaaaga   170220
caatgcagaa aatcttagat ttaagaaaaa aatatcactt gcagatgcaa gttgaacgtt   170280
atatagaaga tgattctggg atgccagaaa gcgataagtc gtttatagac acagggaatt   170340
agaattattg tgagagtttt tgtagtttga aagtattgaa aatcgtaaag atatcattac   170400
gagaatacaa gaagatattg ttctatttcc attaaaaatt acttctttcc ttaacaataa   170460
ggaaaaagaa tgcgttttca tcttttggtt taaggtttat aataagagta tcaaagtcag   170520
gaggaaaaaa gatgactact tttaaagatg gatttttatg gggtggtgct gttgctgctc   170580
atcaacttga aggtggatgg caagaaggtg gcaagggaat tagtgttgct gatgttatga   170640
ctgctggtcg tcatggagta gctcgtgaaa ttactttggg agttttagag ggtaaatatt   170700
atccaaatca tgaggcgata gatttttatc accgttataa agaagatata gcactttttg   170760
ctgaaatggg attcaagtgc ttccgtacct ctattgcatg gacacgtatc tttccaaaag   170820
gtgatgagtt agagccgaat gaagaaggat tacagtttta tgataatctt tttgatgaat   170880
gcttaaagaa tggtattgaa cctgtcatca ctctatctca ttttgaaatg ccttatcact   170940
tagtgaccga atatggtggt tggaaaaata ggaaattgat tgatttcttt gctcgttttg   171000
cagaagtcgt atttaaacgt tacaaagata aggttaaata ttggatgact ttcaatgaaa   171060
tcaataatca agcgaattat caggaagatt ttgcaccatt tactaactca ggtattgtat   171120
atgaggaagg tgataataga gaagcaatta tgtatcaagc agcacattac gaattagttg   171180
cttctgcacg agctgtaaaa attggtcatg agattaatcc agattttcaa ataggttgta   171240
tgattgcgat gtgtccaatt tatccagtta cttgcaatcc taaggatatc ttaatggcaa   171300
tgaaagctat gcagaagcgt tattattttg ctgatgtgca tgttttaggt aaatatcctg   171360
agcatatttt caagtattgg gaacgaaaag gtatttcagt tgattttact gcccaggata   171420
aagaagattt acttggtggg actgtagatt acattggttt cagttactat atgtcctttg   171480
ctatcgactc tcatcgtgaa aataatcctt attttgatta tcttgaaaca gaagatttag   171540
tgaaaaataa ttatgttaag gcttctgaat gggagtggca aattgatcca gaaggtttgc   171600
gttatgcgtt aaattggttt acagaccact atcacttacc actctttatt gttgaaaatg   171660
gttttggagc tatagatcaa gttgcagcag atggtatggt acatgatgat tatagaattg   171720
aatatctagg tgcccatatt cgtgaaatga aaaaggctgt agttgaagat ggtgttgatt   171780
taatgggtta tactccatgg ggatgtattg atttggtttc agctggtacc ggtgaaatgc   171840
ggaaacgtta tggctttatt tatgtagata aagatgataa tgggaaggga agttataatc   171900
gttccccgaa aaaatctttt ggctggtata aggaagttat ttcatctaac ggtgaatcag   171960
tagaatagta taaacaaact gagattattc tcagtttgtt tagcatattg aggtgacata   172020
tgattggaag tattgcagca attttaacaa catttgcatt tttaccacaa gtttttcgtg   172080
tagttaagac aaaggacaca ggatctattg ctctaggtat gtatgttatg caagttattg   172140
gtattgcatt gtggcttgct catggtattc gtataggaga cttgcctttg attttagcaa   172200
atagtgtttc atttctactc tcaggaataa ttttatttta taaattgaag tataaataat   172260
ttttttccat atcatttagg aaaatgaggg aattgtcatt ggaaacgctt tattttataa   172320
taaaaataga taacaaataa gccaacttag cacagctttg attggattta agaaaaggag   172380
aaaatattat ggcaaaagct ttaattattt gtgcagcagg aatgtcttca tcacttatgg   172440
cacagaaaac aacagagttt ctaaaaggaa aagggaaaga tattgtagtt gatgctatta   172500
gtgctactga aggagggaaa gctatcgcag cagcagcttt tgatttgtat cttgtcagtc   172560
ctcaaacaaa aatgtacttt aagcaatttg aagaggctgg ttctaaagca ggaaaaccag   172620
ttgtacaaat acctcctcaa gcctatattc ctattccaat gggaattgaa aaaatggcta   172680
atttgattct tgagaatatt tgatgaacac atgaaatgtc aataaatatt taggttaaga   172740
taaattgttt tgagtttgat ataaactgat ttaagtgtat aatatgcttc aatatatgaa   172800
aacatacgtt ttaggaggga atgaatgtgt taaacattaa agagaaagat atccttcaat   172860
ttttaataaa aaataaggaa cgttttgtta caagcaaaga actggcagaa tatttatcct   172920
gttcagatag aactgtccgt aatgtactga aattaattga gaagacaatg attattcaag   172980
gagtccggtt gatttcaaaa caaggtcaag ggtatcaaat attttttgag aatcaaggcg   173040
cttaccagga gtttagacaa acttatgaac tggaagaaga ctatacgaaa actgcggttt   173100
caaaaggtga tgatcgttta gtatttatct taaataaatt attatttgag caagttccag   173160
ttctttttga tgatttagct gatgaacttt acgttagtcg ttcaacatta tctcatgatt   173220
tcagaaagat acgagtgatg ttatcagagt ataatttgtc cattgagagt agggcgaata   173280
aaggagttta tgtctcaggc gaggaacgtg ataaacgacg ttttatcata aattatttcc   173340
tagagaatca attttttaaa acaatacatt gctatgtaaa atttaacttt tttgatcaaa   173400
ctgttccatt agaagaattt gctagaattg ttttggatga atgccaagag gccaacctaa   173460
aactatctga ttttgtacta cagaatttag tagttcacat agcattgtct gtgattcgtt   173520
taaaatccgg atttgaaata aaaaatatag actgtcagat gactgatgat gcaatagaga   173580
gaaaggttgc ccaaagaatt ctttctaaag taagagaagt aacaaatcag gaatttccag   173640
ttcaggaaat agactacatt actttgcatt tgttagctaa gagtcaacaa tgtcaaaaaa   173700
atcagaagaa tatttctgaa gaagttttaa aaaaatcttt atttaaaaca tttcagaatt   173760
taggattaga tgatatgtat aacttttctt cagatttcca actaattgaa ggattgataa   173820
ctcatctaat gacactacaa gtacgtttag aaagccggat taccttaaat aaccctttgg   173880
tagatgaaat taaacagaat tatagtgata tattctttat gactagagaa attcttgcaa   173940
atatggacaa gttcttggag tggacaatat cagatgatga agtagcatat gtaagtcttc   174000
actttttagc tgctatggaa cgtagcaaag agagtactaa gtttaatatt cttgctattt   174060
gtgcaacagg atttggtgca gcccaaatgt taagaaatcg tttggaaacg gagtttggga   174120
agcgagtaga agttgttgat gtaataggct actatgaatt gaatcaagaa aaacttaaag   174180
gaatagattt tatagtgtca gctattgatt tatcaaatct atattttcaa atcccagttt   174240
ttaaagttag tgtgtttctt aagagtgatg agatggaaat gattagaaaa gctatggatt   174300
agatgcaagt ttctagttat gtacaatcat caaagattaa caaatttgaa aacaacggct   174360
ttagacagta ttttagtaaa gaaaactttt taatatgtac tgaatcagac aaggtaaatt   174420
tacttgaaaa gatggttgag agtttatctg ttggtgaatc aaatgagttt gaacaatctt   174480
tactttatgg aattaaacag cgcgaagaat taagttcagt tgttttttct gaaaaaattg   174540
cagttccgca tcctattcag ccctttggta cagagggaaa ggtttcggtt gcaatttgta   174600
aagattcgtt actctgggat aatcaaagtt cacatgtcca gctagtattt cttctatctc   174660
catcaatata tgggaacgaa ggtttggcaa ctgtgactaa aaagatagtc tctctgacag   174720
agaatgatga attgcaaaat cagctaatat cttgcaataa ctttgaagat tttattaaca   174780
tatttgagaa gataaaatag gaggtttata tgaatcaaga ggaactgcag gttgcagcat   174840
ttgaaattat cctgcattcg ggaaatgcaa ggtcagaaat acatgaagca tttgcaaaaa   174900
tgagagaagg tagttttgat gatgcagaaa gtaaattaaa tcaatcaaat gagataattc   174960
ttgaagcgca tcatgcacaa accaaactct tgcaagaata cgcaagtgga gtggaaatta   175020
aaattgaaat tatcatggta catgctcaag atcatttaat gaccactatg acattattag   175080
aagtagcaaa ggaaatgtta gctctttata agaaagttaa ctaaatatgt gttgttatat   175140
aaggaggaaa tgatatggat aaaaaagaac gacaaaagat tgaacaacaa cgtcgagaga   175200
tggctctaac taatactttt ttcaatcgat atcttcttct acgttattca atagcactct   175260
tcttttttgg gaatatttat tggcttttga gtcagtttat tagtccctcg cctattatta   175320
ttttccccat tatgctcata gtattttcta ttttagcaac tgttgaacaa tttaaacttt   175380
atggaaatag gaaagaaaag ttgggaataa cactaatgtt tgttagaata caaatgctta   175440
tttcaatagg attacttgtt ttaacttgga caagttggtt taagaatctt tttccgattt   175500
ttgaaaataa ccaagtagca cgtttatttg tttttgtagt tcttctatta ggtttagttc   175560
tgagtttgtt agacattaga agaattaaaa aaatttataa acgaacagat aaggcttatc   175620
aacaatttgt ccaattggaa aagaactcac ttagtttata atcctgatct agtataattt   175680
gtatttgaaa ctagtcttta gaaagtaaaa attattatgt tttattaagg aggtctattt   175740
atggatcaac aaaacgggtt gtttggtttt cttgaaaacc atgttatggg accaatgggc   175800
aaacttgctc agtttaaagt agtacgtgct atcacggctg caggtatggc tgctgtacca   175860
tttactattg taggatcaat gtttttggta ttcagtattt tgccacaagc tttctcattt   175920
tggccaattg tggcagatat tttctctgct tcatttgata aattcacatc actttacatg   175980
gttgcaaact atgcgactat gggttctcta tctctttatt tcgttctatc acttgcatat   176040
gaattgacaa aaatttatgc agaggaagaa gaactcaata tgaatcctct taatggtgcc   176100
ttgcttgcct tgatggcttt tgtcatgaca gtaccgcaaa tcatttttga tggtggaatg   176160
atgaagactg tgacaagtct aaaagaaggt gcagtaattg cagatggatg ggcaatggga   176220
aatgtagtcg cacgttttgg gacaacaggg atttttaccg caatcattat ggcaattgtg   176280
actgttctta tttatcgtat gtgtgttaaa cataattggg ttattaaaat gcctgaagct   176340
gttccagaag gagtttctcg tggatttacc gctttggttc cgggatttgt tgttgcattt   176400
gttgttatct ttatcaacgg tcttcttgta gcaatgggaa cagatatttt taaagtcatt   176460
gcaattccat ttggttttgt atccaatctg actaattcgt ggattggttt aatgattatt   176520
tatctattga ctcaactact ttggattgta ggtatccacg gtgcgaacat tgtttttgca   176580
tttgttagtc caattgctct tgctaacatg gctgaaaatg ctgctggcgg gcacttcgct   176640
gttgcaggtg aattttctaa tatgtttgta attgcaggtg gttctggtgc aactttagga   176700
ctatgtttat atattgcttt tgcctctaaa tctgaacagc ttaaagcaat aggacgagca   176760
tctgtagttc cagccttatt taatattaat gaaccattaa tttttggatt acctattatc   176820
tataatccag ccttggctat accatttatt ttagcaccaa tggttactgc tactatttat   176880
tacgtagcga attctctaaa ctttattaag ccaattatcg cacaggttcc atggccaact   176940
ccagtaggga ttggagcttt cttagggaca gcagatcttc gagctgtatt agttgctcta   177000
gtatgtgcat ttgcagcatt cctagtctat cttccattca tccgtgtata tgatcaaaaa   177060
ttggtgaaag aagagcaagg tatctaataa gtaaaaaagt atactcgatg atagaatcca   177120
tatagtttaa ataatgagtg ttaatattag cagtgaagag gtctttttaa gatattcttc   177180
tctgcttttt catatttttt cgctatgtag ggtatgaagc aaaatagaaa gtagttcgaa   177240
tagttgataa acagggaact gctgttattt aaaaaaacaa taaagtaaag tatgttatcg   177300
tagaatacga tacaatagta aaaaagcaaa aagaatgcgt tttatatttg ggtttgaggc   177360
ttataaaata ggataagcgt gctgaaaact tagatatgac aaacaaaata aaatttttaa   177420
aagctacaga gaaacatggt ataatgtatc taaaggaggt agcatatgtc cttagatata   177480
gataaagaaa agatgacaat catgggaata gcttttgaaa accgatccgt ttttaagagt   177540
gtttggtatg ctttaagtac aaatatgatt gaaggatggc gacctacggt tagtgatgtt   177600
gaaaaattac gagatgaagc tcttgctctg gggatgactt aatgaagcgc aactgttatg   177660
aatcttatga ctatgttgat ccggataatt tatataccga tccgggttct tcagttctaa   177720
gaaataagca ggaaggaaaa aagcacgtga gcttgaatat cgtatgattg ctagtaagag   177780
tttgaaatta tttatcaatc ctatcttagt taatagttta aaagtagttt gtttcacaac   177840
tgcataagct tagaaaagtt gaaaagtgat aactctttaa taaactcttg gtttgttaaa   177900
agatattttg tccactgcat tttttcaatt gactattatt tgtcatagat ataacagata   177960
gaacattgca ttcagaataa tgaaaaacgc atcaaaaatg gtgcgttctg tttttatgct   178020
accataaaag gaggaaaaca aattgaaaat ttttaaggga gagttttatc gaatctctgt   178080
attaacagac aagctagtaa ggttagaata ctctcaaact ggaagttttg aggatagaac   178140
gacacaactt atctataata gagattttgg ccaaatttcg ttagattata tcgagacatc   178200
aaacgtacta gatattatga cggactattt tcatctgcac tttaataaag gagaatttaa   178260
cgccgaaaat ttatttatag aattaaaagg aaattttgcc gtatatggta gtcgctggta   178320
ttttggtgaa tctattgaaa cgttaaaagg aacagctcgg actctggata aggcagatgg   178380
agcaatctcg ttagaagatg gaattattag ccgaaatggt atagccttat tggatgattc   178440
tcaaggattt atttgggatg aacaatctgg ttatattgag agagaaaatc aaattgacct   178500
gtatttcttt gcctatgggc atgattatag aggagcaatc agagattttt accatttgac   178560
tggttcaaca cccttgttgc caagatatgc tttaggcaat tggtggagta gatattggcc   178620
ttatacgtcg gatgaatact tggatttaat agacagattt gaaacagaga aaattccatt   178680
atctatcggt gtgttagata tggattggca tataactgac attccagctc gctttggaag   178740
tggctggaca ggatatagtt ggaatagaaa cttaatacca aatccagaac agttattgca   178800
acaacttcat gatagaaagc taaaactctc cttaaatgtc catcctgctg atgggatacg   178860
ggcttatgaa gaagcttatc ctcaaatcgc aaaacggttg gggttaaatg tagaactaga   178920
agaacctgct atttttgatt tttttaatcc ctcttttagg gaagcctact ttaaagatgt   178980
tcattatgaa ctagaaaagc agggagtaga tttttggtgg attgactggc aacaagggac   179040
acaaggtatg ctagatccac tttggctttt aaaccattat cactatcagg atagttgtaa   179100
aaatgcagaa ggtggtttga ttttatcaag atatgcaggt cctggtagtc accgctaccc   179160
tgttggtttt tcaggggata ctattattag ttggaattcc ttaagatttc aaccctattt   179220
tacagcgaca gcatctaata tcggttatag ttggtggagt catgatatcg gtggacatat   179280
gttgggggat tatgacgaag agctacaaac tagatggcta cagtttggtg tttttagtcc   179340
gattactcga ttacatagtt ctagaagtcc ttttaatagt aaagaacctt ggtttttttc   179400
agaaacaaca tctaagatta tgaagaaata ccttcgtttg agacatcaga tgattcccta   179460
tctatatacc atgaatgtac agacacatga ggaaggtgcc ccattaatca gtccaatcta   179520
ttatttctat ccagagaatg atgagagcta taatgttcca aaccaatact tttttggaac   179580
agaactgatg gtggctccca ttgtagaaaa gatggatttg acattccaat ctgcaaaagt   179640
agatgtatgg ttccctgaag gtgaatggta tgacttcttt tcagagaaaa aatacacagg   179700
tggtgtgaag ttaagtgttt atagggacat ctcgactacg cctgtgtttg caaaaagtgg   179760
tgcaatcatt cccttggttg gttctgagat aggtatgggt gttgatttac ctgaagttgt   179820
agattggtat gtattcccag gaaaacaaca ttcttttgaa atgcttgaag atcaaaatgg   179880
tcaaagatat aaaacaagat tatcaatcga ttgggaaatg ggaatggtag agttagcatt   179940
acaaggagat tctagtatcg ttccaagcaa tagaaaacat agaattcatt ttaaaggaac   180000
gaatgtgtct ataattgaat tgccaaataa gaatgataca gctaaatttg aatggaaaga   180060
taataaaagg acatctttaa atgacgaagt ttttagacta ctaaagacag cttctcttcc   180120
atatgaatta aaagatagat tgttaaatca attcatcaat gcgaaaaact ctcatgactt   180180
aatgaatatc ttgcatcatc aggataagga attgagaggg cgtttgttgg aaatgatatt   180240
tactagccaa aactaattga aataattaga aagtcatttg tttagtgtat atgaagattc   180300
tgtatggtat tcgttatcac tggtcacatt gaaattgtga aataagcacc tacaacatag   180360
actttacaac acttcatgtt tcatatcatg gggtgttttt ctatttaagt caaagcccat   180420
caaaaaatct cactattcat caggttaaag gaaacctaat catagtgaga ttgtgaatta   180480
tagtagagtt tgtatcgcct cttcaatttg ttttgggtct gtttttgaag aaaagcgttc   180540
aaagacttgc ccatctcgac cgatgagaaa cttagcgaaa ttccattcga ctcgttttcc   180600
tagtgggccg gatttctggt cttgtaacca gacatagaga gggtctgctt ccttaccgtt   180660
gaccttaatc ttggcaaaac gtgggaaggt ggtttgaaaa tgtaggctac agaaggcgtt   180720
gatttcctct gcgctgccgg gtgcttgtcc cataaactga ttgcaaggga aatccaatat   180780
ttcgaagccc tgatcttgat agcgttcata gagttcttga agtccctggt actggggcgt   180840
taaaccacat ccagtagcag tgttgacaat caagagaact ttgccacgat agctatccaa   180900
gggagttgct tggttgtttt ggttcaaaac ggaaaaatca taaagtgaag tcatgagggc   180960
ctcttttctt tttctacatt gtaacagttt ttactttttt cgtcgagtcg gatggaagat   181020
attgttgaag aataagcctt caatatgata gaaaccgttt acaaataact ttaaaaatgg   181080
tatgatttaa ttaaaccggt ttacttagtt gctataaatc tctaatttga gatttagttc   181140
ctattgattt tacaatatgt ttattggagt gtatacatgc aaacaaaaac aaagaagctc   181200
attgtgagtt tgtcttcact tgttttatca ggatttttat taaaccatta tatgacaatt   181260
ggagcggaag aaacgactac gaataccatt cagcaaagcc agaaggaagt tcagtatcag   181320
caaagggata caaaaaattt agttgaaaat ggtgattttg gtcagacgga ggacggaagc   181380
agtccgtgga caggaagcaa agctcagggg tggtcagctt gggtagacca gaagaatagt   181440
gcagatgcct caactcgagt cattgaggct aaggatgggg ctatcactat ctcaagccat   181500
gagaaattaa gggcagcgct tcaccgtatg gttcctattg aagctaagaa aaagtataaa   181560
ctgcgtttca agattaaaac agataataaa atcgggattg ccaaagttcg tatcattgag   181620
gaaagtggta aggacaagcg attgtggaat tctgcaacga cgtcaggaac aaaggactgg   181680
cagaccattg aagcagacta tagcccgact ttagatgttg ataaaatcaa gctggagtta   181740
ttctatgaaa caggaactgg gactgtttcc tttaaggata ttgagctggt agaggtagca   181800
gaccagcttt ctgaggattc tcaaacagat aaacagcttg aggaaaagat tgatttacca   181860
attggaaaaa aacatgtttt ttctcttgcg gactatactt ataaggtaga aaatcctgac   181920
gttgcttcag tcaaaaatgg aattttagaa cctcttaagg aagggacaac caatgtcatt   181980
gtcagtaaag atggcaagga agtgaaaaag attcctttga agattctggc ctctgttaag   182040
gatgcataca cagaccgttt ggatgactgg aatggcatca tcgctgggaa tcaatactat   182100
gattctaaaa atgaacagat ggccaaatta aaccaggaat tggaaggaaa ggtagctgat   182160
agcctatcca gtatttcaag tcaggcggac cgcacctatt tgtgggaaaa attttcaaat   182220
tataaaacgt ctgcaaatct gactgccact tatcggaaat tggaggagat ggccaagcaa   182280
gtgaccaatc cttcttctcg ttattatcaa gatgaaactg tcgttcgaac agtcagggat   182340
tccatggaat ggatgcataa acatgtctac aatagtgaaa agagcattgt tgggaactgg   182400
tgggattatg aaatcggtac acctcgtgcc atcaacaata ccttgtctct gatgaaagaa   182460
tacttctctg atgaggaaat taaaaaatat acagatgtga ttgaaaaatt tgtaccagat   182520
cccgaacatt tccgaaagac gactgataac ccattcaagg ctctaggtgg aaacttagtt   182580
gatatgggaa gggtaaaagt aatagctggt ttactgcgta aggatgatca agaaatttct   182640
tctaccattc gctcgattga gcaagtgttc aagttggtag accaaggtga aggtttttat   182700
caagatggat cctatatcga ccacaccaat gttgcctata cgggtgctta tgggaatgtt   182760
ttgattgatg gcctgtctca actgttgcca gtcattcaaa agaccaagaa tccaatcgat   182820
aaagataaaa tgcaaaccat gtaccactgg attgataaat cgtttgctcc tttgctggtg   182880
aatggagagt tgatggatat gagtcgtgga cgctcgatca gtcgtgcaaa tagcgagggg   182940
cacgtggccg cagtagaagt actaagaggg attcaccgaa tagcggatat gtctgaagga   183000
gaaaccaaac aatgtttgca gagtcttgtg aagaccattg ttcaatcgga tagttattat   183060
gatgtcttta agaatttgaa gacttataag gatatcagtt tgatgcaatc cttgttaagt   183120
gatgcaggag tcgcaagtgt tccaagacca agttacctat ctgcctttaa caagatggat   183180
aaaacagcca tgtacaatgc agagaaaggg tttggatttg gcttgtcact cttttccagt   183240
cgtaccttga attacgaaca catgaacaag gaaaataaac gtggttggta tacgagtgat   183300
gggatgttct atctttacaa tggcgatttg agtcactata gcgatggcta ctggccaaca   183360
gttaatccat ataagatgcc tggtacaaca gagacggatg ctaagagagc ggatagcgat   183420
acaggtaaag ttttaccgtc tgctttcgtt ggaacgagca aactagatga tgccaatgcg   183480
acagcaacca tggatttcac caactggaat caaacattga ctgctcataa gagctggttt   183540
atgctaaagg ataagatcgc ctttttagga agcaatatcc aaaacacttc aacagatact   183600
gctgcaacta caattgacca gagaaaactg gaatcaggta atccatataa agtctatgtc   183660
aatgataaag aagcctccct tacagaacaa gaaaaggatt atcctgaaac ccaaagtgtc   183720
tttttagaat cgttcgattc gaaaaagaat attggttact ttttctttaa gaagagttca   183780
atcagtatga gtaaggcttt gcaaaaggga gcctggaagg atatcaatga aggacagtca   183840
gacaaggaag ttgaaaatga atttcttacg attagtcagg ctcataagca aaatagagat   183900
tcttatggct atatgctcat tcctaacgtg gatcgtgcca ccttcaatca aatgataaaa   183960
gagttagaaa gtagcctcat cgaaaataac gaaacccttc agtctgttta tgatgctaaa   184020
caaggagttt ggggcattgt gaaatatgat gattctgtct ctactatttc caaccaattc   184080
caagttttga aacgtggagt ctataccatt cgaaaagaag gggatgaata taagattgcc   184140
tactataatc ctgaaaccca ggaatcagct ccagatcagg aagtctttaa aaagctagag   184200
caagcagctc agccacaagt acagaattca aaagaaaagg aaaaatctga agaggaaaag   184260
aaccattcgg atcaaaagaa tctccctcag acaggagaag gtcagtcaat cttggcaagt   184320
ctagggttct tgctacttgg ggcattttat ctattccgta gaggaaagaa caactaattt   184380
gttcatcatc tagatgaatt acatgaaact gtggaaaata gaaaaaatcc gaagaaggcc   184440
aaatatcttc ggatttttct tttaaaaaag gataagttga tacttatcct tttttacttc   184500
attattatgt gactatagcg ttttgaaact agaatagaac gttataactg ctaaaagatt   184560
tctataaatt catttgattt tcctaatcaa tttgttcgta tcctatttca ctccactata   184620
ttagtccgtc tcgctccgtg aggtgcgaga caaaacaacc acccgctata cgggtgcgcg   184680
tcgaaggtta taccaaaaaa actccaaacg cgatacaata aaggtgttca atccaattgt   184740
aaagcgaaag gagaaaaaat atggcacaaa agactcatag tttatcatac acaaagtgga   184800
ggtgttctat catattgtgt tcacccctaa gtatagacga aaagtcatct ataatcaata   184860
tagaagtagt ttagacgaaa tatttcatcg cttgtgtagt tataaaggtg ttgaaatgat   184920
cgagggtcac ttaatgccag accatgtaca catgttagtc agtattccgt cgaggctaag   184980
tgtttcaagt tttatggggt atttaaaagg caaaagtgca ctcatgatgt ttgacaaaca   185040
cgccaatctc aagtacaagt ttgggaatcg gcatttctgg gaggaaggtt attatgtaag   185100
tccagtaggg cttaatgaag ccacaattaa gaaatatagt caagattaaa gaaattatcg   185160
agtggatgat ttcttcatga gtatgaaaat ttgagaacga gtaaagtatg atatatagta   185220
aaatgaaata agaacaggac aaaatcgatc aggacagtca aatcgatttt taacaatgtt   185280
ttagaagcag aggtgtacta ttccagtttc aatctactat agcactagat aaattgagtg   185340
taaaagaata tgaggatccc tttagggata gtggtaagta ataccaaagt ctcttaaaga   185400
ggcaagtgac gagtcaagag caataaggct tgaacaacgt gaaagccagc gtctttaggc   185460
gctggctgat gatttgggct tatagctctg agataaacca cccgttagac gggtagttat   185520
gattttatct gagtgtaata tactgttggg caatctcgct gatgcggtca aagttgcctt   185580
gggaagcgag tttattgagt tcgccaccaa ttccaacggc atctgcacca gcagcgaacc   185640
attgagggat gttgtttagg ccgactcctc cggttaccat tacggaaact tgtgggatcg   185700
gtgccttgac tgcagagata tatgctggac tgagagtact acctgggaag agtttgatga   185760
tttcactacc ggcttcaagt gcagtcgtga tctctgtgag ggtaatacag cctggaatgt   185820
acggtgtgct gtagagattg cacattttcg cagtttcagc atggaaagat ggagaaacaa   185880
cgtaatttgc tccagctaga atggcatctc tagcagttac ggcatcaagc acagtacctg   185940
caccgataca aacactctga tcgtcctgat acaagtctac aagttccttg atgatttgtc   186000
ctgcatactg attggtatag gcgatttcaa tagctttgat accgcccttg atacaagcaa   186060
tcgaggcttg tagtccttct tcctttgtat ttcctcgaat aacagcgaca attttttgtt   186120
tttttagttc aataatcgta tctgatttgg tcatgtaatt ctcctaacga atgatatctt   186180
gtgcatttgc cagtaaattt tcaatactag ttgaggaagt ggagagatgg tctcctggaa   186240
gagtgcattt gagagttgcg ctcgcaactg caaagtcaat ggtagttttt agggaggaat   186300
gatggagtag ttggtaaagg gcaccagata taaaggcatc cccgctacca attcgttgat   186360
agactgcagt ttttagttgg acagactctt caaatagttc ttctagagca taggcttgat   186420
agacattttt gtcttgctca tcactagagc ggagggtatg gaaaatggcc ttgaaaccat   186480
aggcttcttt taaaagtcgc atgcgatttt ccacctcttc taggctagca ctgtctcttg   186540
gaaacatctc tagattttgg tcatcaatca tgagaggatc aataccgaag caatagtcag   186600
taaaacgtgc aaacttagaa aattcatact tggcttctag gactgaaatc atctttgttc   186660
tcagattgag atccattgaa acgacaattc ctcggcgctt ggcttcttcc aagagtagga   186720
gaaggatcgc acggacctct tgaccgatag ctacggtgat tccactaaaa tgaaaatggc   186780
taatcccctg aaagagagaa tccatatcta gcatgtttgg ccgaatctgg ctgatactcg   186840
tatgcttacg atcgtagaaa acttcacttt gacgacaacc aaagccgttc tccaaatagt   186900
agaggccgat tcgatcgcca agccgacaga ttgaactggt atcgatttgg tgctgtttca   186960
agaatgtgag aaaacgatct ccaatctcgt tggcagggag tgcggtaaaa actttcgttg   187020
agatacccag ggcttgcaaa ttacaagcga tgttaatttc tgatccgcca aaataagtcg   187080
aactggcaac atgatcgccg atactggtgg catctaatgg tgaaattcga attaatggtt   187140
cgccaaacag taatattttc gtcatccatt agttcctttc tggtttagaa tagctttact   187200
tggctaatac ttctttcaaa taagcagcaa cttcatcatc ttggcagttt tcaaagaagt   187260
attcttggaa gtatttgcca gagatggtgt ctttgaggaa gtcttggtcg attattttaa   187320
ggatggtcat caaatcattg tgggtgattt gtttcacctc gtttaagata cgagcgttgc   187380
gttgttcagg gattacacgt tctcttgggt agccaccgcc catttcttca gcaaataagc   187440
gttcaaacat caatttgagg gtcagttctg ccccccagcc aaatcctttg gcataaggga   187500
tagacaaggc gttaccacca ttgatttgag aataaaggta agcgtcagtt gggtccactg   187560
ctagaccaca gacaacacca gggaagctgt ttaaagcaag catagcccct acacccgtac   187620
cacagccggt aacaacaaag tcaactgcct ttgtatttaa aaggatggca gccattagtc   187680
cgttctgcac ataagttaat tgactttctc cttcttctcc acgcatacca tagttaaata   187740
attggtagcc ttttttatct gtcgcttctt ttagactatc gtaaataatg tgattcttgc   187800
tagcttgact attttcattg attaatgcga ttttcataag atcttctttc tatttttact   187860
caggttgttt tccgatgtag gctaagatac cgccatctac atataggatg tggccattga   187920
caaaattgct ggcatcacta gcgagaaaga cagcagggcc catcaaatct tcagtatttc   187980
cccaacgtgc agcaggtgtt tttgcaatga tgaactggtc aaatgggtgg cgagaaccat   188040
cttcttgcaa ttcacgaaga ggtgctgttt gaggagtggc aatataaccc ggtccaattc   188100
cgttacattg gatattggct ccaccgtatt cagacgcaat gttgcgggtc aacattttca   188160
agcccccttt agcagcagca taagcgctaa ctgtttcacg tcccagttcg ctcatcatcg   188220
aacaaatatt gataatcttt ccatgccctt tctttatcat agaaggaata actgcctttg   188280
aaacgataaa tggtgcgttt aagtcaatat cgatgacctt acggaaatca gcggcgctca   188340
tttcgcacat tggaactcgg cggataatac cagcgttatt aacgaggatg tcaatgacac   188400
caacctcttg ttcgatttgc ttgaccatgg cttggatacc gtcctcgtct gtcacgtcac   188460
agacatatcc atgggcttgg atgccaactt cacgataagc ttcaatccct ttattgacca   188520
gatcttgatt gatatcgtta aagacaatag tagcgccggc ttcagcgtag gatttggcaa   188580
tagcaaatcc aattccataa gaagcgccgg tgatgagagc aatttttcct tttaaagaaa   188640
actgctcaat tgagaatgat gtatttgtca tttgatactt cctttcaaat ttgttaagac   188700
ttctctataa ccaaattata ttctagtaaa ccggttttgt caataaataa atatttttat   188760
ttataaaaag gtttgttttc ctaaaaaaac ggaagatttt gaaatttctg tctattaaac   188820
tggttaaaaa gataatgaaa gcgctaatat ttttttaaaa aaactattga caagataaaa   188880
ataaaggatt acaatgggga atataaagta aaccggtaaa cctaaaaaga aaggagaaaa   188940
gatgaaaatt gtacttgtag ggcatggaca ttttgctaca gggatttata gttctttaca   189000
attgattgca ggtaatcaag aaaatgtgga ggcgattgac tttgtggaag gaatgtcagc   189060
agatgaactc aagcaaaaaa tcttacttgc aatttcaaat gaagaagaag ttttaatcct   189120
aagtgatctc ttgggaggat cgccattcaa ggtttcttct accataatgg gagaaaatcc   189180
agccaagaca atgaatgttc tctcgggttt gaacttagcc atgttaatgg aagcagtctt   189240
tgctagaatg gctcatagct ttgatgaggt tgttaataaa tcagtagtgg cggcccaggg   189300
cggagtcgta aatggtaaag aattgttttc aacggatgca gaggaagagg aagaagattt   189360
cgaatcgggt atttaaaggg taaaagaatg ataaaaaagg ttacgattga aaaaataaaa   189420
tcgcctgagc gcttcttaga agtaccactt ctgacgaaag aagaagtcgg ccaggcaatc   189480
gataaggtta ttcggcagtt agaactcaac cttgactatt tcaaggaaga tttcccgacg   189540
ccagctacct ttgataatgt ctatccaatc atggataaca cggaatggac caatggtttc   189600
tggacaggag aactgtggtt ggcttatgaa tacagtcaac aggatgcatt taaaaacatc   189660
gctcataaaa atgttctttc tttcctggat cgtgtcaata agagagtaga attggatcac   189720
catgatctcg gcttcttgta cacaccgtct tgtatggctg aatataagat aaatggagat   189780
ggagaggcta gagaagcaac cttgaaagct gcagataagt tgattgaacg ctatcaagaa   189840
aaaggtggtt ttattcaagc ttggggagac ttgggcaaga aagagcatta ccgtttgatt   189900
atcgactgct tgctcaatat ccaactctta ttctttgctt atcaagaaac aggcgatcaa   189960
aaatactacg atattgcaga aagccatttc tatgcttcag ctaataatgt aatccgtgat   190020
gacgcttcgt ccttccacac cttctatttt gatcctgaga caggtcaacc ctttaaaggt   190080
gtaacgagac aagggtatag tgatgattca tgctgggcac gtggtcaatc atggggagtc   190140
tatggtattc ctttgactta tcgtcactta aaagacgagt cctgctttga cttgtttaag   190200
ggtgtgacca attatttctt gaatcgtctg ccaaaagatc atgtgtccta ttgggatttg   190260
atttttaatg atggtagtga tcaatcacga gattcttcag caacagctat cgccgtctgt   190320
gggattcatg aaatgctaaa acatctccca gaggtggatg ctgacaaaga tatttataaa   190380
catgctatgc atgccatgct tcgttccttg atcgaacatt atgcaaatga tcaatttacc   190440
cctggtggga caagtctcct ccacggtgtg tactcatggc attcaggtaa aggagtggat   190500
gaaggcaata tctggggtga ctactattac ctagaagccc ttatccgttt ctacaaagac   190560
tggaacctat attggtagga ggagaaatat gacaatgcca aatattatta tgacccgtat   190620
cgatgaacgg ttgattcatg gacaaggaca actttgggta aaatacctag gttgtaatac   190680
ggtcattgtt gccaatgacg aagtaagcac ggacaagatg caacaaactc tgatgaaaac   190740
agttgtgcca gactcagttg ccatgcgttt cttccctttg caaaaggtga ttgatatcat   190800
tcacaaggct aatcctgctc aaacgatctt tatcgttgta aaggatgtga aggacgcttt   190860
aaccttggta gaaggtggtg tcactatcaa agaaatcaat attgggaaca ttcacaatgc   190920
ccctggtaaa gagcaagtga cacgctccat cttcctgggt gaagaggaca aggcggccct   190980
caaggaattg agccaaactc atcaagtaac atttaatacg aaaacaactc caacaggaaa   191040
tgatggagct gttcaagtca acattatgga ctatatttaa aagaggagat cgttatgtcg   191100
attaatgtat ttcaagcgat tttaattgga ttatggacag ctttctgttt tagtggaatg   191160
ctgttaggaa tttacaccaa tagatgtatt gttctgtcat ttggtgtcgg aattattcta   191220
ggtgatctgc ctactgctct tgcaatggga gctattggtg aattggctta tatgggattc   191280
ggtgttggtg ctggaggtac tgttccacca aacccaatcg gacctggtat ctttggtacc   191340
ttgatggcta tcactagtgc tggtaaagtc agtccagaag cggctcttgc cctctctact   191400
ccgattgctg tggcgattca attcttacaa actttcgcct acactgtacg tgctggtgcg   191460
cctgaaacag ctatgaagca cttgaaaaac cataatttga agaaatttaa gttcactcta   191520
aatgcaacaa tttggttgtt tgcctttatt ggatttacct tgggttgctt gggtgccctt   191580
tcaatggata ccttgttgaa actcgtagac tacattccac cggtattact tacaggtttg   191640
acagttgctg gtaaaatgct cccagctatc ggttttgcga tgatcttgtc agtgatggct   191700
aagaaagagt tgattccctt tgtcttgttg ggatatgttt gtgcagctta tctaaacatc   191760
ccaacaattg gtattgcaat tgtaggtact atctttgctt tgattgaatt ttataacaag   191820
ccaaaaacag cggatcatgt ggtagaggag gaagcacacg atgactggat ctaacaaatt   191880
aacaaaacgt gattatctta aaacgtcttt gcgggcattc ttttgtcaaa atggatttaa   191940
ctatagtaac tatcaagggt tgggatatgc caatgtgatg tatcctgctt tgaaaaaaca   192000
ctatggagag gatcaggaag gtttctacca agccttggaa gaaaactgtg aattctataa   192060
taccaaccca cacttcctgc cttttattac cagcttgcat cttgtaatgt tggaaaatgg   192120
ccgtccggca aaagaaacac gtagcatcaa gatggccttg atgggaccat tggcaggtat   192180
tggggattct ctttctcaat tctgtttagc tccattgttc tcaaccatcg cagcttcgtt   192240
tgctcaagaa ggcttggttg tcggtccaat cttgttcttc cttgcgatga atacgatttt   192300
aacagcgatt aaattgtcaa ctggtctgta tggatacaaa ctaggaacaa ctgtgattga   192360
taaactaagc gaacagatgg caacgatttc tcgtattgcc aatattatcg gtgtaaccgt   192420
aattgctggt ttggcagcga catctgttaa gattatggtg ccgattacct ttgctgcagg   192480
ggaagttaaa gcagacgcta aacaaagtat cgtaagtatt cagggaatgc ttgataaggt   192540
tgctccagct cttctaccag ccctatttac acttttagtt tactacttga tcaaagaaaa   192600
gaaatggaca acatataaac tcgttatttt aacagttatc atcggaatta tcggaagctg   192660
gcttaagatt atagcttaat ggatacaaca ttgttttatg gaatagtgat tgtcttggca   192720
gtgagtcccc ttttactgtc aagctttcat tctattcgtc agcaaaagtt gcttcgcaaa   192780
cagatggagc aacgacaaga gtatttagct tctttaacat ttggtgatga agtgttgtta   192840
ttgtctggaa ttcatggaaa aatcatttct atccaagatg acttggtctc cttgcagatt   192900
gcaaaaggtg tggtcatcca tgtagaaaag gaaagtgtaa tgggaaagac aaaagaactg   192960
ctttttaagt agttcttttt ctggtaatag ataatgaaag aagaaagaag acaatttttt   193020
gaaagagtcg atggaaatca atgtcgtgat tatatcttgt cgcactgttc aaaagactat   193080
gagaaagtca agagttccct tgaacgcttg atggacaatc gttttatgtt tgatagtcct   193140
tgggatatgg agccttgttc aaaaatccat caaatccagc cgatggtatg ggatcaagta   193200
tttgaagatg atccagaatg gtcttatatg ctcaatcgac aagaatatct cttgcagttt   193260
atgatagggt atctggtaga aggagataag gactatattc aaaagtgcaa gttctttcta   193320
tttgattgga ttgagcaggt gagagaattt tctcctcaat ccttgatgac tagaaccttg   193380
gatacgggta ttcgttcctt tacttggttg aaactactct tgctcctctt gaaatttgac   193440
ttgctagagg agaaagaact agagaaaatt ttggtcagtc tagaaaagca gattgacttt   193500
atgaaaagct actatcgcgc caagtacacc cttagtaact gggggatttt acaaacaatt   193560
ccgatgcttg ctatctatca tttcttttca gataagatgg atctagaaga agcttaccat   193620
tttgcttcag aggagttgaa acagcaaatt gagacacaga ttttaggaga tggaagccag   193680
tttgaacagt cgattctcta tcatgtagag gtttataaag ccttgctgga tttgtgtctc   193740
ttgcttccag acttgcaaga tagttaccaa gagttgctgg aaaagatggc gacctatatt   193800
caaatgatga caggcttaga tggacggact ttggcttttg gtgatagcga ttctacagaa   193860
acgacagaaa ttttgagcct gtctgctgtg gttttgaacc aggaagacct tcttaacggt   193920
ctggatgtta aagttgattt gcttagcctc ttgttcctgg ggcgagaaaa ggtcaagcga   193980
ctgcaggaat ttgaaaagag agcttggcag cctaagtcca tgatctttga agactctgga   194040
catgtctgca ttaaggatga acatcgttat ctatttttca aaaatggtcc gctaggaagt   194100
gcccatagtc atagtgacga gaatagtttt tgcttacagt atcaaggcca acctattttc   194160
atagatgctg ggcgttattc ttatcgggag atatatgaac gttatctctt aaagagtgct   194220
tggagtcatt cgacctgcat tgtagatggg aaagctccgg aaagaatcac gggatcctgg   194280
gaatatgaat actatcctca ctccctgttt tgtcaccata aagaaaggga gggagtgcat   194340
tatattgagg gggcttattg gtcagcagaa cctgatttgc cttatcttca caggagaaaa   194400
atcctcatgt tggtagagga tgtctggctc ttggtagatg acatcaggtg tcaaggtcaa   194460
catgaggtgt tgactcagtt tatccttgac aaggatgtga cctatcaaga tgggaaaatc   194520
aatcagttga gactatggag tgaagttgat tttgatttgg aagataccat catttctcct   194580
aaatccccaa ttattcaccc caaatctaaa aaccatccag aatccttgcc ttagcttaga   194640
tcctggatgg tttctttttt cacccaatgg gtgtttttta ctagacaaaa aagagtttcc   194700
cctttatggt ataagtgtag aaaaaaacac aaaaagaaag gaaactcaca tgaacagttt   194760
accaaatcat cacttccaaa acaagtcttt ttaccaacta tctttcgatg gaggtcattt   194820
aacccagtat ggtggtctta tcttttttca ggaacttttt tcccagttga aactaaaaga   194880
gcggatttct aagtatttag taacgaatga ccaacgccgc tactgtcgtt attcggattc   194940
agatatcctt gtccagttcc tctttcaact gttaacaggt tatggaacgg actatgcttg   195000
taaagaattg tcagctgatg cctactttcc aaaattattg gaaggagggc agcttgcttc   195060
acagccaacc ttatcccgtt ttctttccag aactgacgag gaaacagtcc atagtttgcg   195120
atgcctcaac cttgaattgg tcgaattctt tttacagttt caccagctaa accaactcat   195180
tgtagatatc gattctaccc atttcacaac ttatggcaag caagaaggtg ttgcttataa   195240
cgcccactat cgtgctcatg gctatcatcc tctttatgct ttcgagggga agacaggtta   195300
ttgtttcaat gcccagcttc gtcctggtaa tcgttattgt tctgaagagg cagacagctt   195360
tatcacacct gttttagaac ggtttaatca acttctcttt cgaatggata gtggctttgc   195420
gaccccaaaa ttatacgatt taattgaaaa aacagggcaa tactacctca taaaactcaa   195480
gaaaaatact gttctgagcc gtcttggaga cctttccctc ccttgcccac aggatgagga   195540
cttaaccatc ttgccccact ccgcctactc agaaactctc tatcaagcag gatcttggtc   195600
gcacaagcgt cgtgtctgcc agttctctga acgaaaagaa ggaaacttgt tctacgatgt   195660
tatttctctc gttacaaata tgacgagtgg aacaagccaa gaccagtttc agctttatcg   195720
tggacgtggt caagccgaga atttcatcaa ggagatgaag gagggatttt ttggcgataa   195780
aacggatagt tcaaccttaa tcaaaaacga agttcgtatg atgatgagct gtatcgccta   195840
caatctctat ctttttctca aacatctagc tggaggtgac ttccaaactt taacaatcaa   195900
acgcttccgc catctttttc ttcacgtggt aggaaaatgt gttcgaacag gacgcaagca   195960
gctcctcaaa ttgtctagtc tctatgccta ttccgaattg ttttcagcac tttattctag   196020
gattagaaaa gtcaacctga atcttcctgt tccttatgaa ccacctagaa gaaaagcgtc   196080
gttaatgatg cattaaagaa cagtcgagat gaaaaaatcg tgtgacgaac caagggagga   196140
gtctgccctt ttgaggaaat ctagcgagga aaaacgatac tggaacagca gaaagtaaaa   196200
ctgacctcat gaggaggaag aaagtggctc atgaggtcag gggttttgta agttacatct   196260
agttgagaga ggtatgaatg atttgggtaa atacaatgag cttgaaagaa gtagcaaact   196320
caccaagcgc caattctttg agaatcagat gctggattat accatcattg cgcatgagag   196380
ttttgaaatc atccgtcatt ctgtctacca gacagatgat cgtgaagtgg aaaatgctct   196440
ggcttttgaa gtgaaaaatg atgaaacaga caagctgatt ctgttattaa gcgaggatat   196500
tggtgtaggt gaaaaattgt gcctcgttga cggaacaaaa atgcgtggaa aatgtttagt   196560
atatgataaa ataaatgaga gaatgattcg cttgcagtgc tagaaatagg cattttgaat   196620
agtgaatatg ttataataag tattagtagg aggtgtttta gattggagaa gaaactgacc   196680
ataaaagaca ttgcggaaat ggctcagacc tcgaaaacaa ccgtgtcatt ttacctaaac   196740
gggaaatatg aaaaaatgtc ccaagagaca cgtgaaaaga ttgaaaaagt tattcatgaa   196800
acaaattaca aaccgagcat tgttgcgcgt agcttaaact ccaaacgaac aaaattaatc   196860
ggtgttttga ttggtgatat taccaacagt ttctcaaacc aaattgttaa gggaattgag   196920
gatatcgcca gccagaatgg ctaccaggta atgataggaa atagtaatta cagccaagag   196980
agtgaggacc ggtatattga aagcatgctt ctcttgggag tagacggctt tattattcag   197040
ccgacctcta atttccgaaa atattctcgt atcatcgatg agaaaaagaa gaaaatggtc   197100
ttttttgata gtcagctcta tgaacaccgg actagctggg ttaaaaccaa taactatgat   197160
gccgtttatg acatgaccca gtcctgtatc gaaaaaggtt atgaacattt tctcttgatt   197220
acagcggata cgagtcgttt gagtactcgg attgagcggg caagtggttt tgtggatgct   197280
ttaacagatg ctaatatgcg tcacgccagt ctaaccattg aagataagca tacgaatttg   197340
gaacaaatta aggaattttt acaaaaagaa atcgatcccg atgaaaaaac tctggtattt   197400
atccctaact gttgggccct acctctagtc tttaccgtta tcaaagagtt gaattataac   197460
ttgccacaag ttgggttgat tggttttgac aatacggagt ggacttgctt ttcttctcca   197520
agtgtttcga cgctggttca gccctccttt gaggaaggac aacaggctac aaagattttg   197580
attgaccaga ttgaaggtcg caatcaagaa gaaaggcaac aagtcttgga ttgtagtgtg   197640
aattggaaag agtcgacttt ctaaaatgaa ggaaaatgac ttgcaatctc tgttaagaaa   197700
taaaataatc ccacctagaa caagctaggt gggattattt gcctatgaaa tgagaaatta   197760
tgggagcaag ctcctaaatc aactgttttt gatctacttc tttaactact tgataaaagt   197820
tatagaagta ggccaaactt gaaatgatgg ttacgactag gaatattgaa aatttccatt   197880
ggacagggtt ggttaaaagt tgtggaaagg atatgaggag aaagaagagg gctgcgttga   197940
ggacaggtat ccgttttgat tgtattttct caagtccttt attgagcgca ggaagaaaga   198000
ggagtaggag tagtaaaact gtatgagaaa tagctcctga agtaagggcg aagaaaagga   198060
aaatactgat aaaaacatga atgatcagta gtctagctag tgatttcata aggcacctcc   198120
taatcctggt cttttttagc tcttgcaata cgaagtgagt cgacaatatg tatcatcact   198180
ccgaaaaaga aagctcccag tatagtttta aaaatatgtt ttgtatttag aagagaactg   198240
ataaaatttg gattttcact tgttagggta tcaatgagtg gaattataaa aaatatcact   198300
gttccataaa tcgaacctgc tttcagacca ggataacgta actgtttctt ttcttttttc   198360
atgagtttcc tcctaatcct catcttgatt tttcttagtt tttgcaatgc gacgggagat   198420
gaggaactgt atgctcgctc cgaagaaaat agaaccgaga atacttgata caccatttct   198480
tatagtgaga agagaatgaa aatagtcctg accttcatct atgagtatcc tgagaagagg   198540
agttataaaa aacatccata gaccaaagaa caaacctgct ttcagacctg ggtagtgtag   198600
ttgcttgctt tctttctcat tcagcatatc tggttcaatg actgtgatgc ctgttttttt   198660
catttggtag gtgacatagc cagaagcgat gagggcaatc actaaaatca gaggaggata   198720
gattagagcc acttcttgag ggtatttata ggccagaagg agtggaataa gatttccgaa   198780
aatcatcaga taaaagagga tgataaagac ttggttccca atactatcgg cctcacgccg   198840
tttgtattcg tcaaggggac cagaaatacc gtatgtgcgt ttgatcagtt tttcagtgaa   198900
ggtttctttt ttcatgagtt tgctcctttt ttaaaaatct tcctcccaaa agagactgtt   198960
gaggtcagtt tggaggctgc gggcgagatt gagacagagt tccaaggttg gattgtactt   199020
gtcgttttca atcatattga tagtctgtct cgagacaccg atatccttgg cgagttcgag   199080
ctgggaaata cccaattcct tgcgaaattc tttcacacga ttcatctgtt ctcctttctg   199140
atttatgtcg tatatatttg actatattat agtcttttaa acataaagtg tcaagtattt   199200
ttgacatatt ttttgaagaa atagtagtct ccttgtccta tttgtctgac aagtgcaagc   199260
tggtcggatt tgtggtaaaa tagataagat atgacaaaag aatttcatca tgtaacggtc   199320
ttactccacg aaacgattga tatgcttgac gtaaagcctg atggtatcta cgttgatgcg   199380
actttgggcg gagcaggaca tagcgagtat ttattaagta aattaagtga aaaaggccat   199440
ctctatgcct ttgaccagga tcagaatgcc attgacaatg cgcaaaaacg cttggcacct   199500
tacattgaga agggaatggt gacctttatc aaggacaact tccgtcattt acaggcatgt   199560
ttgcgcgaag ctggtgttca ggaaattgat ggaatttgtt atgacttggg agtgtctagt   199620
cctcaattag accagcgtga gcgtggtttt tcttataaaa aggatgcgcc actggacatg   199680
cggatgaatc aggatgctag cctgacagcc tatgaagtgg tgaacaatta tgactatcat   199740
gacttggttc gtattttctt caagtatgga gaggacaaat tctctaaaca gattgcgcgt   199800
aagattgagc aagcgcgtga agtgaagccg attgagacaa cgactgagtt agcagagatt   199860
atcaagttgg tcaaacctgc caaggaactc aagaagaagg ggcatcctgc taagcagatt   199920
ttccaggcta ttcgaattga agtcaatgat gaactgggag cggcagatga gtccatccag   199980
caggctatgg atatgttggc tctggatggt agaatttcag tgattacctt tcattcctta   200040
gaagaccgct tgaccaagca attgttcaag gaagcttcaa cagttgaagt tccaaaaggc   200100
ttgcctttca tcccagatga tctcaagccc aagatggaat tggtgtcccg taagccaatc   200160
ttgccaagtg cggaagagtt agaagccaat aaccgctcgc actcagccaa gttgcgcgtg   200220
gtcagaaaaa ttcacaagta agagggaaaa agatggcaga aaaaatggaa aaaacaggtc   200280
aaatactaca gatgcaactt aaacggtttt cgcgtgtgga aaaagctttt tacttttcca   200340
ttgctgtaac cactcttatt gtagccatta gtattatttt tatgcagacc aagctcttgc   200400
aagtgcagaa tgatttgaca aaaatcaatg cgcagataga ggaaaagaag accgaattgg   200460
acgatgccaa gcaagaggtc aatgaactat tacgtgcaga acgtttgaaa gaaattgcca   200520
attcacacga tttgcaatta aacaatgaaa atattagaat agcggagtaa gatatgaagt   200580
ggacaaaaag agtaatccgt tatgcgacca aaaatcggaa atcgccggct gaaaacagac   200640
gcagagttgg aaaaagtctg agtttattat ctgtctttgt ttttgccatt tttttagtca   200700
attttgcggt cattattggg acaggcactc gctttggaac agatttagcg aaggaagcta   200760
agaaggttca tcaaaccacc cgtacagttc ctgccaaacg tgggactatt tatgaccgaa   200820
atggagtccc gattgctgag gatgcaacct cctataatgt ctatgcggtc attgatgaga   200880
actataagtc agcaacgggt aagattcttt acgtagaaaa aacacaattt aacaaggttg   200940
cagaggtctt tcataagtat ctggacatgg aagaatccta tgtaagagag caactctcgc   201000
aacctaatct caagcaagtt tcctttggag caaagggaaa tgggattacc tatgccaata   201060
tgatgtctat caaaaaagaa ttggaagctg cagaggtcaa ggggattgat tttacaacca   201120
gtcccaatcg tagttaccca aacggacaat ttgcttctag ttttatcggt ctagctcagc   201180
tccatgaaaa tgaagatgga agcaagagct tgctgggaac ctctggaatg gagagttcct   201240
tgaacagtat tcttgcaggg acagacggca ttattaccta tgaaaaggat cgtctgggta   201300
atattgtacc cggaacagaa caagtttccc aacgaacgat ggacggtaag gatgtttata   201360
caaccatttc cagccccctc cagtccttta tggaaaccca gatggatgct tttcaagaga   201420
aggtaaaagg aaagtacatg acagcgactt tggtcagtgc taaaacaggg gaaattctgg   201480
caacaacgca acgaccgacc tttgatgcag atacaaaaga aggcattaca gaggactttg   201540
tttggcgtga tatcctttac caaagtaact atgagccagg ttccactatg aaagtgatga   201600
tgttggctgc tgctattgat aataatacct ttccaggagg agaagtcttt aatagtagtg   201660
agttaaaaat tgcagatgcc acgattcgag attgggacgt taatgaagga ttgactggtg   201720
gcagaacgat gactttttct caaggttttg cacactcaag taacgttggg atgaccctcc   201780
ttgagcaaaa gatgggagat gctacctggc ttgattatct taatcgtttt aaatttggag   201840
ttccgacccg tttcggtttg acggatgagt atgctggtca gcttcctgcg gataatattg   201900
tcaacattgc gcaaagctca tttggacaag ggatttcagt gacccagacg caaatgattc   201960
gtgcctttac agctattgct aatgacggtg tcatgctgga gcctaaattt attagtgcca   202020
tttatgatcc aaatgatcaa actgctcgga aatctcaaaa agaaattgtg ggaaatcctg   202080
tttctaaaga tgcagctagt ctaactcgga ctaacatggt tttggtaggg acggatccgg   202140
tttatggaac catgtataac cacagcacag gcaagccaac tgtaactgtt cctgggcaaa   202200
atgtagccct caagtctggt acggctcaga ttgctgacga gaaaaatggt ggttatctag   202260
tcgggttaac cgactatatt ttctcggctg tatcgatgag tccggctgaa aatcctgatt   202320
ttatcttgta tgtgacggtc caacaacctg aacattattc aggtattcag ttgggagaat   202380
ttgccaatcc tatcttggag cgggcttcag ctatgaaaga ctctctcaat cttcaaacaa   202440
cagctaaggc tttagagcaa gtaagtcaac aaagtcctta tcctatgcct agtgtcaagg   202500
atatttcacc tggtgattta gcagaagaat tgcgtcgcaa tcttgtacaa cccatcgttg   202560
tgggaacagg aacgaagatt aaaaacagtt ctgctgaaga agggaagaat cttgccccga   202620
accagcaagt ccttatctta tctgataaag cagaggaggt tccagatatg tatggttgga   202680
caaaggagac tgctgagacc cttgctaagt ggctcaatat agaacttgaa tttcaaggtt   202740
cgggctctac tgtgcagaag caagatgttc gtgctaacac agctatcaag gacattaaaa   202800
aaattacatt aactttagga gactaatatg tttatttcca tcagtgctgg aattgtgaca   202860
tttttactaa ctttagtaga aattccggcc tttatccaat tttatagaaa ggcgcaaatt   202920
acaggccagc agatgcatga ggatgtcaaa cagcatcagg caaaagctgg gactcctaca   202980
atgggaggtt tggttttctt gattacttct gttttggttg ctttcttttt cgccctattt   203040
agtagccaat tcagcaataa tgtgggaatg attttgttca tcttggtctt gtatggcttg   203100
gtcggatttt tagatgactt tctcaaggtc tttcgtaaaa tcaatgaggg gcttaatcct   203160
aagcaaaaat tagctcttca gcttctaggt ggagttatct tctatctttt ctatgagcgc   203220
ggtggcgata tcctgtctgt ctttggttat ccagttcatt tgggattttt ctatattttc   203280
ttcgctcttt tctggctagt cggtttttca aacgcagtaa acttgacaga cggtgttgac   203340
ggtttagcta gtatttccgt tgtgattagt ttgtctgcct atggagttat tgcctatgtg   203400
caaggtcaga tggatattct tctagtgatt cttgccatga ttggtggttt gctcggtttc   203460
ttcatcttta accataagcc tgccaaggtc tttatgggtg atgtgggaag tttggcccta   203520
ggtgggatgc tggcagctat ctctatggct ctccaccaag aatggactct cttgattatc   203580
ggaattgtgt atgtttttga aacaacttct gttatgatgc aagtcagtta tttcaaactg   203640
acaggtggta aacgtatttt ccgtatgacg cctgtacatc accattttga gcttggggga   203700
ttgtctggta aaggaaatcc ttggagcgag tggaaggttg acttcttctt ttggggagtg   203760
ggacttctag caagtctcct gaccctagca attttatatt tgatgtaaga atggcaccct   203820
gatgtttcag ggtgtttttg tgtttaaata cacaatgaaa atcaaagaac aaactagaaa   203880
gctaacttta ggctgctcaa aatatagtag attgaaacta gaatagtaca catctacttc   203940
taaaatattg ttagaaatcg atttgactgt cctgattgat ttgtcctgtt cttatttcgt   204000
tttaatatac agttttgaga tggttgatag aactgacgaa gtcagctcaa aacacggttt   204060
tgaggttgta gataaggaga agctgatgtg gtttgaagag gttttcgaag agtgtaaaaa   204120
aatattggtc agttaaagtc aaaactcttg accttttctg accaatgtag tatattatga   204180
acgtaaggta aatgaaagcc ttactagaac acttatttaa agtaaaatag aaagaggtgg   204240
gtctatgttt catctagaaa tcttcagaag taaagatagt ctactcctgc ttgaaaaaga   204300
aaaaccagaa atagtacgta gggtagcgat ctagctagtc taaatttttt aaaacaatgg   204360
tcaaagatag tcaatatcag taatcataac taagtaaaca aaaagaggta aagaatatga   204420
ataacaactt taataatttt aataacatgg atgatttatt taaccaattg atgggtggta   204480
tgcgaggata cagttctgaa aatcgccgtt acttaattaa tggacgcgaa gtcacacctg   204540
aggaatttgc tcactatcgt gcgactggtc aattaccagg aaatgcagaa actgatgtgc   204600
aaatgccaca acaggcatca ggtatgaaac aaggcggtgt ccttgcaaaa ctaggtcgaa   204660
acttaacagc agaagcgcgt gagggcaagt tggatcctgt tatcggacga aacaaggaaa   204720
ttcaagaaac atctgaaatc ctctcacgcc gcaccaagaa caatcctgtt ttggtcggag   204780
atgcaggtgt tggtaagaca gcagttgtcg aaggtctagc gcaagccatt gtgaacggag   204840
atgttcctgc tgctatcaag aacaaggaaa ttatttctat tgatatctca ggtcttgagg   204900
ctggtactca ataccgtggt agctttgaag aaaatgtcca aaacttagtc aatgaagtga   204960
aagaagcagg gaatattatc ctcttctttg atgaaattca ccaaattctt ggtgctggta   205020
gcactggtgg agacagtggt tctaaaggac ttgcggatat tctcaagcca gctctctctc   205080
gtggagaatt gacagtgatt ggggcaacaa ctcaagacga ataccgtaac accatcttga   205140
agaatgctgc tcttgctcgt cgtttcaacg aagtgaaggt caatgctcct tcggcagaga   205200
atacttttaa aattcttcaa ggaattcgtg acctctatca acaacaccac aatgtcatct   205260
tgccagacga agtcttgaaa gcagcggtgg attattctgt tcaatacatt cctcaacgta   205320
gcttgccaga taaggctatt gaccttgtcg atgtaacggc tgctcacttg gcggctcaac   205380
atccagtaac agatgtgcat gctgttgaac gagaaatcga aacggaaaaa gacaagcaag   205440
aaaaagcagt tgaagcagaa gattttgaag cagctctaaa ctataaaaca cgcattgcag   205500
aattggaaag gaaaatcgaa aaccacacag aagatatgaa agtgactgca agtgtcaacg   205560
atgtggctga atctgtggaa cgaatgacag gtatcccagt atcgcaaatg gaagcttcag   205620
atatcgaacg tttgaaagat atggctcatc gcttgcaaga caaggtgatt ggtcaagata   205680
aggccgtaga agttgtagct cgtgctatcc gtcgtaaccg tgctggtttt gatgaaggaa   205740
atcgcccaat cggcaacttc ctctttgtag ggtctactgg ggttggtaag acggagcttg   205800
ctaagcaatt ggcactcgat atgtttggaa cccaggatgc gattatccgt ttagatatgt   205860
ctgaatacag tgaccgcaca gctgtttcta agctaattgg tacaacagca ggctatgtgg   205920
gttatgatga caatagcaat accttaacag aacgtgttcg tcgcaatcca tactctatca   205980
ttctcttgga tgaaattgaa aaggctgacc ctcaagttat tacccttctc ctccaagttc   206040
tagatgatgg tcgtttgaca gatggtcaag gaaatacagt aaacttcaag aacactgtca   206100
ttattgcgac ctcaaatgct ggatttggct atgaagccaa cttgacagaa gatgcggata   206160
aaccagaatt gatggaccgt ttgaaaccct tcttccgtcc agaattcctc aaccgcttta   206220
atgcagtcat cgagttctca cacttgacta aggaagacct ttctaagatt gtagatttga   206280
tgttggctga agttaaccaa accttggcta agaaagacat tgacttggta gtcagtcaag   206340
cggctaaaga ttatatcaca gaagaaggtt acgacgaagt catgggggtt cgtcctctcc   206400
gtcgcgtggt tgaacaagaa attcgtgata aggtgacaga cttccacttg gatcatttag   206460
atgctaaaca tctggaagca gatatggaag atggcgtttt ggttattcgt gagaaagtct   206520
aagacagaat tttgaggata aaaaagaagg agccagctga aaaaaactgg ttccttttta   206580
ggtacgacag gcatgtcgta tagtagaagt gtattattct agtttcaata tactatagta   206640
gctcagaagt cggtacttaa acgtgctata tcaaaaccag tcctggaaaa acgtggactg   206700
gtttcgtgtt tggattatta ccttgaacga catgcgttaa aagttagttg aaccgccgta   206760
tgccgaatgg tacgtacggt ggtgtgagag gggctagaga ttatccccta ctcgatttta   206820
aatcacatga cgttcaaagg catcatctga aatcccttgt tccaagatga gttttgccca   206880
ttctttagca gagaagaggc tgtggtcctt gtagtttccg caagattcga tggttgtccc   206940
tgggacatct tcccaagtag tagtttcagc gatttccttg agcgaatcct tgataacagc   207000
tgcgatttta gcactggtgt gacgtcccca cataatcatg tggaagcctg tgcggcaacc   207060
aaatggtgaa cagtcaatca tgccgtcaat gcgggtacgg atgagtttgg ctaagaggtg   207120
ctcgatagtg tgaaggccgg cagtagggat agagtcttcg tttggttgca ccaagcgaat   207180
atcataattg gagatgatgt ctccttttgg tcctgtttct tccccaatca agcgaacata   207240
gggtgctttg acaatggtgt ggtcaagttc aaaactttcg acaataactt cttttgacat   207300
ggtaaatcct ttcagttttc ttctctcatt atatcataaa ggttgctcct gagacagaga   207360
gaaaacctct ccgaggctgg agaggttgaa atctttactt acgatataag cggtcgtatt   207420
ggtagtatgg gtcaaaggtt acgttgatac ccagtttacg aaggacattc ttgtcttcat   207480
cagtcaagat gatggttgag tgggcttcgc ttcctttgag gttgccgagt tcttccatag   207540
cgcgggcagc atcaggattt tctgtagctg tgatagcaag tgcaatcagg atttcatttg   207600
aatgaaggcg tggattgcgg ctaccgagat gatcgatttt aagaccttgg attggcttaa   207660
caacttcagg ctcgattagt tttacttctt tagcgatgtc agctgatttt ttgatggcgt   207720
tgatcaaggc agcggctgta ggaccaaaga gttctgagtt cttaccagtg atgatttccc   207780
catttggcaa ttcaaaggct agggctggtc caccagtttc ttctgctttt tggcgcgcaa   207840
cgacagcaac cttacggtct gcaggtgtga taccgaggtc gttcatgagc aactcaattt   207900
tcttgacggc agcttcgcca actttttcag ctttgaagtc aagaactgtt tgatagtaac   207960
ggcggatgat ttcttgttta gaagcttcga cagcggcctc gtcatctgta atagcgaaac   208020
caaccatgtt gacacccata tctgtcggtg aagcgtatgg tgattttccg agaatacgtt   208080
ccaacatgcg tttgagcact gggaagattt cgatatcacg gttgtagttg acagtggttt   208140
ctccataggt ttgaagatgg aaggggtcaa tcatgttgac atcatcaagg tcagctgtgg   208200
cagcttcata agccaagtta actggatgat gaaggggaag attccaaaca gggaaggttt   208260
caaatttagc gtagccagat ttgatgccat tgatttggtc gtggtacata ttggacatac   208320
acgttgccaa ttttccagaa ccaggtccag gagcggttac gacaatcaag ttgcgactgg   208380
ttttgatgta gtcgtttttg cccatgcctt ctggggaaat gatgtgatcc atatccgtcg   208440
gatatccttt gattggataa tgaagataag aatcaattcc gtttttctca agttgattgc   208500
ggaaggcatc tgcagcgggt tggccagcgt attgtgtaat gacaacggaa ccaacaaaaa   208560
tccctaattc attgaattta tcaatcaaac gaagaacttc ttggtcataa gaaatgccta   208620
agtcgccacg tgctttggaa tgttcaatgt tgctagcatt aatggcaatc acaacctcaa   208680
cctgctcttt caattcttgc aagagcttga ttttgttgtc aggttcataa ccaggaagga   208740
cacgagcagc gtggaaatct tctaacattt taccgccaaa ctctaagtag agcttgccgt   208800
caaattggtt aatgcgctcc aaaatatggt cgcgttgtaa attcaaatat tgttcagaac   208860
taaaagcttg ttttttcatt tttttacctc tggactctat tataataaaa aattggaagt   208920
taggaaacta cggagctaaa aaagaaatta aaaagattaa gcaaacgctt gcacaaaatt   208980
ttaaaaagtg ctatcataga ctatagatta tgaaaataat gaggtaaaca gatgcaagaa   209040
aaatggtggc acaatgccgt agtctatcaa gtctatccaa agagttttat ggatagtaat   209100
ggagatggag ttggtgattt gccaggtatt accagtaagt tggactatct agctaagcta   209160
ggaatcacag caatttggct ttctcccgtt tatgacagcc ctatggatga taatggctat   209220
gatattgctg attatcaagc gattgcggct atttttggaa ccatggagga catggatcag   209280
ctgattgcag aagctaagaa gcgtgacatt cgtatcatca tggacttggt ggtcaatcat   209340
acctcagatg aacatgcttg gtttgtcgaa gcctgtgaaa atactgacag ccctgagcga   209400
gactactata tctggcgcga tgaacccaat gacctagatt ctatctttag tgggtctgct   209460
tgggaatacg atgaaaagtc aggtcaatac tatctccact ttttcagcaa gaaacagccg   209520
gatctcaact gggaaaatga aaaacttcgc cagaaaattt atgagatgat gaacttctgg   209580
attgataaag gtattggtgg tttccgtatg gatgttattg acatgattgg caaaattcct   209640
gacgagaagg tagtcaataa tggtcctatg ctccatccct atctcaagga aatgaatcag   209700
gcgacctttg gagataagga tctcttgaca gtaggggaga cttggggagc aactccagag   209760
attgccaagt tctactctga tccaaagggg caagaattgt ctatggtctt ccagtttgaa   209820
catatcggtc ttcagtatca ggaaggtcag cctaaatggc actatcaaaa agagctgaat   209880
atcgctaagt taaaagaaat cttcaacaaa tggcagacag agttaggagt tgaggacggc   209940
tggaattccc tcttctggaa caaccatgac ctccctcgta ttgtctcaat ctggggaaat   210000
gaccaagaat accgcgaaaa atctgccaaa gcctttgcaa tcttacttca tctcatgaga   210060
ggaactcctt atatctacca aggtgaggag attgggatga ccaactatcc gtttgaaaca   210120
ctggatcaag tagaagatat tgaatctctc aactatgcgc gtgaggctct tgaaaaaggt   210180
gttccgattg aagaaatcat ggacagtatc cgtgttattg gacgtgacaa tgcccgtacc   210240
cctatgcaat gggacgagag caaaaacgct ggtttctcaa caggtcaacc ttggttggcg   210300
gttaatccaa attacgagat gatcaatgtc caagaagcgc tggcaaatcc agattctatt   210360
ttctatacct atcagaaact ggtccaaatt cgcaaggaga atagctggct agttcgagct   210420
gactttgaat tgcttgatac ggctgataag gtctttgctt atatacgtaa ggatggcgac   210480
cgtcgcttcc tagttgtggc taacttgtcc aatgaagagc aagacttgac agtagaagga   210540
aaagtcaaat ctgtcttgat tgaaaacact gcggctaaag aagtacttga aaaacaggtc   210600
ttggctccat gggatgcttt ctgtgtggaa ttactataaa tattttttgc agaaaaattt   210660
aaaattgaaa tcgtataaaa acaagggagg actgtataaa agacagaaat cctttgtttt   210720
ttataaccaa agtttataaa ctttcattct tgaaattcaa ttaactttac aaattcccac   210780
tattaaggag aaagaagatg aacataaaga agcgtgtcct tagtgcaggc ctgacttttg   210840
catctgcttt gcttttaccc aaatcattca tacctctctc aactagatgt aacttacaaa   210900
acccctgacc tcatgagcca ctttcttcct cctcatgagg tcagttttac tttctgctgt   210960
tccagtatcg tttttcctcg ctagatttcc tcaaaagggc agactcctcc cttggtgcgt   211020
cacacgattt tttcatctcg actgttcttt aatgcatcat taacgacgct tttcttctag   211080
gtggttcata aggaacagga agattcaggt tgacttttct aatcctagaa taaagtgctg   211140
aaaacaattc ggaataggca tagagactag acaatttgag gagctgcttg cgtcctgttc   211200
gaacacattt tcccaccacg tgaagaaaaa gatggcggaa gcgtttgatt gttaaagttt   211260
ggaagtcacc tccagctaga tgtttgagaa aaagatagag attgtaggcg atacagctca   211320
tcatcatacg aacttcgttt ttgattaagg ttgaactatc cgttttatcg ccaaaaaatc   211380
cctccttcat ctccttgatg aaattctcgg cttgaccacg tccacgataa agctgaaact   211440
ggtcttggct tgttccactc gtcatatttg taacgagaga aataacatcg tagaacaagt   211500
ttccttcttt tcgttcagag aactggcaga cacgacgctt gtgcgaccaa gatcctgctt   211560
gatagagagt ttctgagtag gcggagtggg gcaagatggt taagtcctca tcctgtgggc   211620
aagggaggga aaggtctcca agacggctca gaacagtatt tttcttgagt tttatgaggt   211680
agtattgccc tgttttttca attaaatcgt ataattttgg ggtcgcaaag ccactatcca   211740
ttcgaaagag aagttgatta aaccgttcta aaacaggtgt gataaagctg tctgcctctt   211800
cagaacaata acgattacca ggacgaagct gggcattgaa acaataacct gtcttcccct   211860
cgaaagcata aagaggatga tagccatgag cacgatagtg ggcgttataa gcaacacctt   211920
cttgcttgcc ataagttgtg aaatgggtag aatcgatatc tacaatgagt tggtttagct   211980
ggtgaaactg taaaaagaat tcgaccaatt caaggttgag gcatcgcaaa ctatggactg   212040
tttcctcgtc agttctggaa agaaaacggg ataaggttgg ctgtgaagca agctgccctc   212100
cttccaacaa ttttggaaag taggcatcag ctgacaattc tttacaagca tagtccgttc   212160
cataacctgt taacagttga aagaggaact ggacaaggat atctgaatcc gaataacgac   212220
agtagcggcg ttggtcattc gttactaaat acttagaaat ccgctctttt agtttcaact   212280
gggaaaaaag ttcctgaaaa aagataagac caccatactg ggttaaatga cctccatcga   212340
aagatagttg gtaaaaagac ttgttttgga agtgatgatt tggtaaactg ttcatgtgag   212400
tttcctttct ttttgtgttt ttttctacac ttataccata aaggggaaac tcttttttgt   212460
ctagtaaaaa acacccattg ggtgaaaaaa gaaaccatcc aggatctaag ctaaggcaag   212520
gattctggat ggtttttaga tttggggtga ataattgggg ttttagctgc ttgcggccaa   212580
tcaggttcag atacaaaaac ttactcatca acctttagtg gaaatccaac tacatttaac   212640
tatctattag actattacgc tgataatata gtcaattgaa acaagaacaa gacaaaagag   212700
cctcataaaa ggtattgcaa cttggtaata cctttttgag gtgctttttg atatgagccc   212760
atgttttctc aataggattg tactcaggtg agtagggagg aagaggtaaa agtttatacc   212820
caaactcttc acacaagagt tctaacttac ccattctatg gaatcttgca ttatccataa   212880
taataaccga tggtgtgttt aatgttggta agagaaattt ctgaaaccaa gcttcaaaaa   212940
agtcgctcgt catcgtctct tcgtaagtta ttggagcgat taactcacca tttgttagac   213000
ctgcaaccaa agaaatcctc tgatatcttc ttccagatac tttgcctctt cttaactgac   213060
cttttaatga gcgaccatat tctcgataaa aataagtatc gaatcctgtt tcatcaatct   213120
aaacaggtgc taggtgcttt aaactattaa aattcttaag aaataaggct actttttctg   213180
ggttttgttc atagtaggtg tggttctttt tttcgagtgt agcccatagc tttgagcgca   213240
tagtggatgg tagttggatg acagccaaat tcagaagcta tttcagtcaa ataagcgtct   213300
ggattgtcag taagatagtt tttaagtcta tctctatcaa cttttcttgg ttttgttcct   213360
tttacttggt ggtttagctc tcctgttttc tcttttagct ttaaccagcc ataaatggta   213420
ttacgtgata tttggaaaac gtgtgatgct tctgttatac tacctgttcg ctcacaataa   213480
gagagaactt ttttacgaaa atctattgaa tatgccataa gaagattata ccacattgtg   213540
tactatatta gattgaaact agaatagtac acctctgctt ctaaaacatt gttagaaatc   213600
gatttgactg tcctgaacga tttgttctgt tcttatttca ttttactata tttttgtttc   213660
gcgggaagtc tactaagata cttaaagatg cagatagtaa aaataaaggt gtagacatta   213720
ccgtaaaaaa gtgatataat cgtataatgt tcaatgtata ggtattaatc atgagtagac   213780
gttttaaaaa atcacgttca cagaaagtga agcgaagtgt taatatagtt ttgctgacta   213840
tttatttatt gttagtttgt tttttattgt tcttaatctt taagtacaat atccttgctt   213900
ttagatatct taatctagtg gtaactgcgt tagtcctact agttgccttg gtagggctac   213960
tcttgattat ctataaaaaa gctgaaaagt ttactatttt tctgttggtg ttctctatcc   214020
ttgtcagctc tgtgtcgctc tttgcagtac agcagtttgt tggactgacc aatcgtttaa   214080
atgcgacttc taattactca gaatattcaa tcagtgtcgc tgttttagca gatagtgaga   214140
tcgaaaatgt tacgcaactg acgagtgtga cagcaccgac tgggactaat aatgaaaata   214200
ttcagaaatt actagctgat atcaagtcaa gtcagaatac cgatttgacg gtcaaccaga   214260
gttcgtctta cttggcagct tacaagagtt tgattgcagg ggagactaag gccattgtcc   214320
taaatagtgt ctttgaaaac atcatcgagt cagagtatcc agactacgca tcgaagataa   214380
aaaagattta tactaaggga ttcactaaaa aagtagaagc tcctaagacg tctaagagtc   214440
agtctttcaa tatctatgtt agtggaattg acacctatgg tcctattagt tcggtgtcgc   214500
gatcagatgt caacatcctg atgactgtca atcgagatac caagaaaatc ctcttgacca   214560
caacgccacg tgatgcctat gtaccaatcg cagatggtgg aaataatcaa aaagataaat   214620
tgactcatgc gggcatttat ggagttgatt cgtccattca caccttagaa aatctctatg   214680
gagtggatat caattactat gtgcgattga acttcacttc gtttttgaaa ttgattgatt   214740
tgttgggtgg aattgatgtt tataatgatc aagaatttac tgcccatacg aatggaaagt   214800
attaccctgc aggcaatgtt catcttgatt cagaacaggc tctcggtttt gttcgtgagc   214860
gctactccct agcagatggc gatcgtgacc gcgggcgcca tcaacaaaag gtgattgtgg   214920
ctatccttca aaaattaacg tcaaccgaag tgctgaaaaa ttatagtacg atcattaata   214980
gcttgcaaga ttctatccaa acaaatatgc cacttgagac catgataaat ttggtcaatg   215040
ctcagttaga aagtggaggg aattataaag taaattctca agatttaaaa gggacaggtc   215100
ggatggatct tccttcttat gcaatgccag acagtaacct ctatgtgatg gaaatagatg   215160
atagtagttt agctgtagtt aaagcagcta tacaggatgt gatggagggt agatgaaatg   215220
atagacatcc attcgcatat cgtttttgat gtagatgacg gtcccaagtc aagagaggaa   215280
agcaaggctc tcttggcaga atcctacaga cagggggtgc gaaccattgt ttctacctct   215340
caccgtcgca agggcatgtt tgaaactccg gaagagaaga tagcagaaaa ctttcttcag   215400
gttcgggaaa tagctaagga agtggcgagt gacttggtca ttgcttacgg ggctgaaatt   215460
tattacacac cagatgttct ggataagctg gaaaaaaagc ggattccgac cctcaatgat   215520
agtcgttatg ccttgataga gtttagtatg aacactcctt atcgcgatat tcatagcgcc   215580
ttgagcaaga tcttgatgtt gggaattact ccagtcattg cccacattga gcgctatgat   215640
gctcttgaaa ataatgaaaa acgcgttcga gaactgatcg atatgggctg ttacacgcaa   215700
gtaaatagtt cacatgtcct caaacccaaa ctttttggcg aacgttataa attcatgaaa   215760
aaaagagctc agtatttttt agagcaggat ttggttcatg tcattgcaag tgatatgcac   215820
aatctagacg gtagacctcc tcatatggca gaagcatatg accttgttac ccaaaaatac   215880
ggagaagcga aggctcagga actttttata gacaatcctc gaaaaattgt aatggatcaa   215940
ctaatttagg agaaatgatg aaagaacaaa atacgataga aatcgatgta tttcaattag   216000
ttaaaagctt gtggaaacgc aagctaatga ttttaatagt ggcacttgtg acaggtgcgg   216060
gggcttttgc atatagcact tttattgtta agccagaata tacgagtacc acgcgaattt   216120
acgtagtgaa tcgcaatcaa ggagacaagc cggggttgac aaatcaggat ttgcaggcag   216180
gaacttatct ggtaaaagac taccgtgaga ttatcctttc gcaggatgtt ttggaggaag   216240
ttgtttctga tttgaaacta gatttgacgc caaaaggttt ggctaataaa attaaagtga   216300
cagtaccagt tgatacccgt attgtctcta tttcagttaa tgatcgagtt cctgaagagg   216360
caagccgtat cgctaactct ttgagagaag tagctgctca aaaaattatc agtattactc   216420
gtgtttctga cgtgacaaca ctggaggagg caaggccggc gatatccccg tcttcgccaa   216480
atattaaacg caatacacta attggttttt tggcaggggt gattggaact agtgttatag   216540
ttcttcatct tgaacttttg gatactcgtg tgaaacgtcc ggaagatatc gaaaatacat   216600
tgcagatgac acttttggga gttgtgccaa acttgggtaa gttgaaatag gagagaagga   216660
tgccgacatt agaaatagca caaaaaaaac tggagttcat taagaaggca gaagaatatt   216720
acaatgcctt gtgtacaaat atacagttga gcggagataa actaaaagta atttccgtta   216780
cttctgttaa ccctggggaa ggaaaaacaa ctacttccat aaatatagca tggtcgtttg   216840
cgcgtgcagg ctataaaact cttttgatcg atggcgatac tcgaaattca gttatgttag   216900
gagtttttaa atctcgtgaa aaaattacag ggctaacaga atttttatct gggacagctg   216960
atttatctca cggtttatgt gatacaaata ttgaaaattt atttgtagtt caatcgggat   217020
ctgtatcacc aaaccctaca gccttgttac aaagtaaaaa ttttaatgat atgattgaaa   217080
cattgcgtaa atattttgat tatatcatta ttgatacacc gcctattgga attgttattg   217140
atgcggcaat tatcactcaa aagtgtgatg cgtccatctt ggtaacagca acaggtgagg   217200
cgaataaacg tgatatccaa aaagcgaaac aacaattaaa acaaacaggg aaactgttcc   217260
taggagttgt tttaaataaa ttggatatct cggttaataa gtatggagtt tacggttcct   217320
atggaaatta tggtaaaaaa taaaatgaat atagtatgga aggggactac aatataactc   217380
tggcattctt acagagcata cttatcagtt tattagctta tgtactgatt gcaatttcag   217440
aaaccgatat gtcttcaaat aatattcggt ctatttggaa gaataattga actggacctt   217500
ctaattcatt attgagaact catatattac tgaaacaaat aaattttgtt tagatggaga   217560
aaagttttat ctgacgtaga ggataaaaga attatatttc tgaaaatcat tgagtgacca   217620
aatatatatt gagtttctgt agttgcatgt actgcctgat ttaatttgtc aaatggaaat   217680
agaatgaaaa atggaaatag aatttatagt tggaggttgt ttatgtacgg tataataaaa   217740
cgattaggtg atatattatt atctttaata gggataataa tattgtgtcc ggtttttatg   217800
ataattgcaa ttgcgattaa acttgattca gaaggtccgg ttatatttaa gcaaaaacgc   217860
tttggtattc ataaagaata cttctatatt ttgaaattta ggtctatgaa aatagatgca   217920
cctaaaaatg tggcgcctcg aaacttatat aatccagagc aatggattac aaaagtaggg   217980
gctttcttgc gaaaaacatc tttggatgaa ctaccacaat tgtttaatat tcttgttggt   218040
aatatgagta ttgtaggtcc tagaccagcg ggtataaatg aactagattt gattgcagag   218100
agagataagt atggagcaaa tgatatcttg ccagggttaa ctggatgggc acaaattaac   218160
gggcgtgata ctttgtctgt tgagatgaag acggagttag atggctacta tgttaaacat   218220
ctgtctttga taatggatat tagatgtata gttaagacaa taccttacgt actgaaacga   218280
aaaggtattg tagagggtag tggtaagaaa gaaagttaaa ttggacaatg aaaatactat   218340
ttgtttgcca acattataag ccagaaccat tcaggttgtc agatatttgt gaagatttag   218400
ttcgaaaagg gcatgaagtc tctgttttgg ctgggattcc taattaccct gaagggaaga   218460
tatatgcaga ttatcgtcat aataaaaaaa gacgtgagat tatagaaggt gttacgatat   218520
atcgttctta tacaatccct agaaaaaaaa gtgttgtatt tcgattgttg aattatttta   218580
gctttgcaat tagttctact ttaggagttt tattggggag gtataaaacg aaagatggat   218640
cgaattttga ctgtgtattc gttaaccaat tgtctccagt tatgatggca tgggctggta   218700
tggcttataa aaaaaaatat aagaaaccga tgtttctata ttgtatggat gtttggccag   218760

atagtttaac cgtaggtgga gtgaaacaag atggcttgat tttcaagctg tttaaattta   218820
tctcaaaaaa agtttaccga gctagtgatt atatatttgt cactagtcca tcatttaaaa   218880
attattttgt gaagcaattt gacatatccg aacaaaagat tacatatttg ccacaatatg   218940
cagaagatct ttttatccct gatgaatcta tagttaataa agaaagtgtt gacctaactt   219000
ttgctggtaa tattggcaaa gcacaaaatt tggaaactat tttgaaagct gccagtttga   219060
tagagaagaa taccaattta cccaagaaaa ttcattttca ttttgttgga gatggtacgg   219120
aattgttaag catgaaagca ttagctcatg aattggagtt aaagaatatt tccttctatg   219180
gaagacgttc tttggaggaa atgccatcct tctataaaaa atcagatgct atgttagttt   219240
ctttaatagg agactcgata gtttctcgta ctatacctgg gaaggtacaa tcttatatgg   219300
cggcaggcaa accaattata ggtgcaattt caggagatgc taaaataatt gtagaagaag   219360
caaattgtgg atatgttagt cccgaacgag atgtaaaaca attggcaaaa aatatttgta   219420
aatttagtat gttatctatt aagagacaaa gagagttagg aaagaaagct cgttgttact   219480
atgaaaatca cttttcaaaa gagcagttta tgctcgaact ggagacatgt ttagagaggg   219540
aaagtaagaa agaataattt aatgagagta ctgtttatac tatctgataa tatatatcta   219600
actccttact tcaattttta taaagaatta ttgaagaaac tgtctattag ttacgatgtt   219660
atatattggg ataagaatat taacgagatt attacaaaac aaaactacta tcgtatttct   219720
ttttctggta aaggaaaatt aagtaagata ttaggttatg taaaattcag aaaagaaatt   219780
aaaaagaagc taaaagaaaa tgattatgat atgatattgc cgttacatag tattgtgtct   219840
ttcattttag tagattttct tctcttttca tttaaaaata gatatattta tgatattcgt   219900
gattacagtt atgaaaaatt tttggtttat cgtttggttc agaaacaatt ggtgaaaaat   219960
tctttaatga atatcgtttc ttcagacggc tataaatttt ttttaccaat gggagagtat   220020
tttactaccc ataacctacc caatatgata gaattaaacg aggtaaagca gttaaaaaat   220080
aatagtacgt ttccaattca actttcctac attggtttaa ttcgttttca agaacaaaat   220140
aaaaaaataa tcgatttttt tgcaaatgac agtcgatttc agttgaattt tataggtact   220200
aatgcaggag aattaaggga attttgtcaa gaaaaaaata tcagcaatgt taacttggtg   220260
gacacattcc agcctaaaga taccatgtct ttttataaga atacagatgt tgttttgaat   220320
ttatacggga atcacactcc cttactagac tatgctttgt ctaataaact ctactttgct   220380
gcattgttgt ataaacctat tttagtttgt gaagatactt atatggaaaa agtgtcaata   220440
gagaatggtt ttggtttcgt tttacctatg aaggatgaat cggaaaaaga ttgtttggct   220500
ttgtatattc aaaaccttga caggaaacag ctaattaaga attgtgataa cttcatggac   220560
agaattagtt tagaaaaaca aaaaacagaa atagaattag agaagcgaat cttaagctta   220620
aggaagaaga atgattaaag tattacatct atttacaaca ctagatagtg gtggagtaga   220680
aagttttcta ttcaactatt attctcacat tgatagaaaa aaaattcaat ttgattttat   220740
tgtgcctgga aaagaacaag gatttttaga ggataaaatg aaagaattgg gtgcaaaggt   220800
ttatcatgtg cctctattaa ggaaaaagcc tctacatcag tttctctctc ttgctagaat   220860
aataaagaaa ggagattatg atatagttca ttgccatggc tataaatctg caattggtct   220920
gatcttatct aaaataattg gttgtaaaat tagaattatt catagtcata tggcttatgt   220980
aacagaaaac agttttcaaa aagtattgcg taaattagta acaattttgg taaaaatctt   221040
agcaactcat tggtttgcat gtggggaaga ttcggctaag tggttatatg gagagaaagc   221100
gtataaagac ggaaaaattg aaattatttt taatgcaatt gatttgaaaa agtatcaatt   221160
tttgtcagat gttagagaaa aatgtcgtag agaattagat gtgtcaaata agttcgtatt   221220
aggaaatata gctcgcctat cagatcaaaa aaaccaaagt tatttattta acgttttaaa   221280
agaactcatt ttaatcaaac caaatgttat tttactccta gttggtaatg gtgaggatga   221340
gcagaaatta aaacagaaag ctttagaact aaatctgacc ccatatgtgc tatttttagg   221400
gagaaggact gatatttctg atttattatc tgcgatggat gtttttttgc ttccgtctaa   221460
atatgagggg ttgcctgttt ctctagtaga ggctcaggca tcgggattac aaattttatc   221520
gtcagataca gtgacgcaag aagtagatgt gaccaaaaac attagttact tacctatcaa   221580
cgaagagtct gtgttgctat ggaaagataa agtactgtct ttaacatctg aggaatgcaa   221640
tcgttttgaa ataaataaca gtatgacaga tggactctat gatatttgtt atcaagctag   221700
taaattattg aatcgttatc aagaaatgtg tgtaataaag gagatataga tgcagacaaa   221760
gtatatttgt agagtgacac tagtgacatt aagttttata tttgctttct gttacttgtt   221820
ctggactctc gataattgga ataatggttt tcttatatct aattatgttc cgtctatatt   221880
tatatgggtt tgctttctaa ttatttttca aattactggt tttattttac aaaaagttag   221940
tatatatgat ttttctgtat ggtatctgat tttatcttat ttttttatgt ttggattaat   222000
tttcaatgag tatatggggt ttcaaacaac tctgctgtgg agccctagta acttctataa   222060
taatgaagaa ttatttcatt catatatttt tataatttgg attttgtttt gttattctgt   222120
aggctattta tttttttata gtgatggaaa ggtacattat cattcagaag tacaaaatta   222180
tcaggaaaat gaagagaaaa ttttgtacaa tgcgggtagg attttaacag gagtgggctt   222240
tatttctagg gtaataactg attctaaaac agtactagca gttagagcgg cgaatagcta   222300
ttcagcatat tcagaggcag ctagttcagg aataatagat gatttaggag tacttatgct   222360
tcctggtgtg ttctccttgt tttattcaga taagctgtcc cgagttataa agcgtactat   222420
tttttgggta atgttgtttt acctaatttt gataatgatc ctaacaggaa gtcgtaaaat   222480
ccaggtgttt tcaatcttgg cgttggtttt agtatacaca caatctttag ggattacttt   222540
ttcgaagaaa agagtacttg tatttttaat agtaactgta tttctattaa atgtattagt   222600
tgttattagg gggcaccgtt tcgacttgaa tactataggt atatacttat ttgattcctt   222660
ttcttcatta gattttgtaa agaatatact aggggaagta ttttcagagt cgggactgac   222720
cagcctaaca gtagcttctg ctgtaactgt tgtgcctagt agcattccat atgaatatgg   222780
gatgacattt ctacgcacta tcctatcaat ttttcctatt ggatggttag ttggtgattt   222840
ttttgataaa gcatcagcga cggttgttat taataaattt ttggggttac ctgtaggctc   222900
ttcttttgtg gaagaattat tttggaactt tggttactat ggtggtgttt tttggagttt   222960
tgttttggga atatttagtg gatggcgatt aaatttcaga gcttttcaaa caagtaaaat   223020
ctcaaaagtt atttattttt cggtaatttc tcaactattg cttttagtga gaagtagttc   223080
aatagatgtt tatcgtccta ttatgtatag tttgattatg atatttattt ttaggaggtt   223140
gaaaaaatag tggtgaaaaa aattatgtta catggtgcaa cggattatgg ttcaagtaat   223200
tacggtgatt atctttacgg tgagattgtc tatgatttat tagaatctaa aggatatgaa   223260
gtttcttttt ataatccatc agatttcttt caaatgtact tgaaagaata tcgccaaaaa   223320
caaagtttta ctaaaaaaca agcagatgct attttgtata tcccgggagg atattttggg   223380
gaagggcata atgcacgttt tcgtgataat ttaatccaat ttaaacgatt tttacctttg   223440
ggaatttggg cttcatattt taaaaagcct ataggagtat taggtattgg tgcagggcct   223500
aataacgatt ctttgatgaa ttatggtata aagagaatta ttaatcatgc tcaatttatt   223560
acagttcgtg atcgagaatc atttgattct ttgaagcatt tgtcgccttc ggctccagtg   223620
catgaaacct ttgatttaat tatttcaagt aaattaagag aagaaaaaac agagcagctg   223680
tgtcaattga aaagagaagc taaagataag aagataattc ttgttcacta taatcattcc   223740
aaaaaagctc ttgaaaaatt tgcggaatca attagtcttt ttctagaaaa caatcctaac   223800
tattatgttg tagtaacttc ggattccatt ctaccttatg aagatgctta ttatcaggaa   223860
tttagaaaat tagttagaac tgaggattgt tttcaattca agtatcattc tcctgcagaa   223920
atgacatcat tgttgaaaat ggtagatgtg gttttaactt gtaaattaca tgttggggta   223980
gtggcaacat gttttaataa atctgtgatt gccattgcat gccatccaga aaaaacagca   224040
cgttattatg gagcaattgg agagttacaa cgttgtgaat ctttatttga ttcaagtgtt   224100
aatagtattg taaagaaact tgaaactttt catctaaaac cgataacaat accttcagaa   224160
ttggtgttga aagcgagaag tagtttggac tatttagatc tttttttgga aggactagtt   224220
cgtgaaagtt gatagaattt catttataaa aaatacaagt tctctctata ttctgaatat   224280
tgttaaatta ctatttcctt tattaacact cccgtatttg acaagggtgc tttcgctaga   224340
cgcgtatgga atggttattt atgttaaagc gttaatagct tatgttcaac tggtgattga   224400
ttttggtttc atgatatcag ctacaaaaaa tattgtaaat gcttgtacta ctccctcaaa   224460
gattggaagg atagttggag atactctagt tgaaaaaata tttttatcta tcatttcgat   224520
tctaatttac accatattga tgtggcaaat cccaataatg agagagaata ttcttttttc   224580
agttttttat ttgttagcta cagtgaccaa tatttttatc tttgactttt tatttcgtgg   224640
aattgaaaag atgcatgcag ttgcaattcc ttatattatt tctaaaacta tcattacaat   224700
tttgacattt attgtagtaa aagatgattc ttctatttta tggattccta tattggaagg   224760
aattgggaat ttagttgctg cagtagtttc ttatagattc cttcattatt atggaattaa   224820
attatcattt tcttatctgt ctgtttgggt taaagattta aaggaatcct ctatttattt   224880
tttatccaat tttgcaacta ctatttttgg cgtctttacg acagtcattt cgggttttta   224940
tttacaaagt caagagatag ccttttgggg gatagcaatg caactgcttt cagcagcaaa   225000
atcattgtat aatcctatag cgaatagttt atatccgcat atgatacgta ctaaagatat   225060
acaatcggtt aagagtatta atcggattat gtttattcct attatctttg gagttttgat   225120
agttttattc ttttcaaatc aaattctttc tataattggt ggtgaaaaat ataccgtttc   225180
agcagatttt cttaagtact tattacccgc ttttgttgct agtttttatt ctatgattta   225240
cggatggcct gtcttaggag ctattgataa agtgaaagaa actacaatga caactatatt   225300
agcttcgatt gtccaaactt tgggattagg aatatttatc ttgtctgata attttagttt   225360
agtaacatta gctatttgtt caagtatgtc tgaggtggtg ttatggatta gccgttatct   225420
aatttatttt aagaaccgtt cattatttgt taggagtaag taaatatatg aaaaaagtag   225480
ttgtagtatt tggaactcgt ccagaagcca tcaagatgtg tcctttggtc aaagagttaa   225540
gaacacgtaa gaatattgaa acattagttt gcgttacggg ccaacaccgt caaatgttgg   225600
atcaggtctt ggacacattt gggattattc ccgattttga tttgtctatt atgaaagata   225660
aacaaacttt atttgatgtg accattggca ttttggaagg aatgaaggct attttagagt   225720
cagaaaaacc tgatttggtg ttagttcatg gggatacaag tacgaccttc gctagttcac   225780
tggcggcctt ttatttacag attccaattg gtcatgttga agctggtttg cgcacttacg   225840
atatctattc accatatcct gaagagttta atcgtcaagc agttggggtt ttggctcagt   225900
atcattttac accaacacaa ctttcaaaag ataatctttt aagagaagga aaaactccag   225960
agagcatatt tgtgacaggt aatacggcga ttgatgcttt acaaactaca attcaagagg   226020
actatacgca tcctgagtta gaatggatag gagaaagcag gtttattcta attacagctc   226080
atcgtcgtga aaatcttggt gaaccgatga gacatatgtt tagagcaatt agaaggatta   226140
ttgaagaata ttcagatgtc aaggctattt atcctatcca tatgaatcct cgtgttcgcc   226200
aaattgctga ggaagaacta agtggctgtg aacgtatcaa gatgatcgaa cctttagaag   226260
tattagattt tcacaatttt ttatcaagaa gttatttaat tttaacagat agtggtggta   226320
ttcaggaaga ggctccaagt ttaggaaaac ctgttttggt tatgagagat acaactgaac   226380
gtccagaggg aattgaagca gggactttga aacttgtagg tgctgatgaa aataatattt   226440
ataggcattt taaagaatta ttagaaaatg attcagttta tcaagcaatg agtcaagctt   226500
caaatccata tggagatgga acggcttgta agaaaattgc agacatacta gaaggagaag   226560
tgtaatatat gtcacaattt acaggaaaaa ctctcctaat tacaggaggg acaggttcat   226620
ttgggaatgc ggttctcaag cgttttttag aaacagatgt ctcagagatt cgtatatttt   226680
cgcgagatga aaagaaacaa gatgatatgc gtcatgagtt tcaggtaaaa gtaccagaag   226740
tggctgggaa aatccgtttt taccttggag atgtgcgtga cttagcttcg gtaaaaaatg   226800
ctatgcatgg tgtggattat gtttttcacg ctgctgctct taaacaagta ccttcttgtg   226860
aatttttccc tgtagaagcg gtaaaaacta acattttggg aacggagaat gtcctcactg   226920
cggctatcga agctggtgta aagcaagtta tctgtctttc tacagataag gcggcttatc   226980
ctgtcaatgc tatgggaaca tccaaggcta tgatggaaaa gattgctgtt gctaagtcca   227040
ggacggtaaa tcctgagcat acaaagatat gtgtgactcg ctatgggaat gttctgtgta   227100
gccgtggatc tgtcgttcct ctttggattg agcaaattaa gcaaggaaat gctcttacaa   227160
ttactgaacc tagcatgaca cgttttgtga tgacattgga agaagcagta gacttggttt   227220
tatttgcatt tgaagaaggg aaatctggag atatactagt tcagaaagca ccagcatgta   227280
cgattgaagt gttggctaag gctgtatcag aaatttttgc ctcagaacaa gatattaaga   227340
ttataggtat tagacacgga gaaaaaaggt atgaaacact attaactaac gaagagtgcg   227400
caaatgcaat tgatttgggt gatttttata gagttcctag tgataatcgt aatcttaact   227460
atgataagta tttcaaagat ggtagtacga atagaaattt gttgacagaa ttcaatagta   227520
ataataccga tttgatggat gtagagcaag ttaaaagaaa gttgctagaa ttagatgaaa   227580
tacagacagc aattcgtgat atggtagcag acgaagagat gtaaaatctt ttaagataca   227640
ttaaaattat caaggatata taatgtatca tgtattgtcg agagagttaa ctattaaaac   227700
agcatataaa ataaggaggg ggcatgatta aaaatatttt aatcacagga gcgaaaggat   227760
ttgtaggaaa aaatcttatc tgtactctgg aagctttgaa agatggacga gataggactc   227820
gtcctaattt agagattgga gagatttttc agtatgatcg tgatacagat ccgattttat   227880
tagatgaata ttgtaagaag gccgatttcg tattccattt agctggtgtc aatcgtccac   227940
agaatcctga tgaattcatg gagggaaatt acggtttttc aagtagatta ttggagattt   228000
tagaaaagta tgaaaacact tgtcctgttc tactctcaag ttctactcaa gctagtttag   228060
aaggccgatt ttcaaactct atatatggac aatctaagct agcaggggaa gaactcttct   228120
ttgaatatgg aaagaaaacg ggagcacctg tcttagttta ccgtttcccg aatctttatg   228180
ggaagtggtg ccgtcctaac tacaattctg ctgtagcaac tttctgttat aatctagctc   228240
acgatttacc tattcaagta aatgatccaa gtgtagaatt ggagttgctg tatattgatg   228300
atttgataca agagtgtcta actgcattgg aaggaaatcc tcatcgttgt aatctagatg   228360
gattacaaat cttacctagc ccatcaggaa actactgcta cgtaccaacg actcatcgtg   228420
caaccttagg agagattgtc tctctattag aaacatttaa aaaacagcct gatagtttag   228480
ttatgcctga aattcctcag ggatcgttta aaaagaaatt gtattctacc tacctatctt   228540
atttaccagt agataagttt aagtttcctc taaaaatgaa tatagatgaa cgaggtagtt   228600
ttacggaatt attaaaaaca gaaaatacgg gtcaattttc tgttaatatt tctaaacctg   228660
gcattaccaa agggcaacat tggcatcatt ctaagtggga atttttcatg gttgtttctg   228720
gtcgtgcttt aatacaagag cgtaggatag ggctggatga aaacggtcaa gagtatccta   228780
ttctgaactt tgaagtgtcg ggcgataaga ttgaagcaat acatatgata ccgggctatg   228840
cacataatat tattaatctt tctgatacag aaaatctaat tactgtcatg tgggctaatg   228900
agtcatttga tcctagacat ccagatactt tttttgaaca agtggagaaa taaatgaaaa   228960
ttaagacaga ttatagtgat attcacttta aagataatgg caaacttaag ttattgatta   229020
ttgtgggaac acgtccagag attatacgtc taagtagtgt tatcactaaa tgtcgaaagt   229080
attttgatgt tattttggca catactggac aaaactatga ttacaattta aatggtattt   229140
tctttgataa tttagggtta gacactccgg acgtatacat ggatgctgtt ggagatgatc   229200
ttggtgctac tgtagggaat attattaata cttcatacaa attgatgaat caaattaaac   229260
cagatgcttt attgatttta ggggatacaa attcttgttt atcagctatt gctgccaagc   229320
gtttacatat tccaattttt catatggagg ctggcaatcg ctgtaaagat gagtgcctac   229380
cggaagagac taatcgtcgg attgttgatg ttatttcaga tgttaactta gcatactctg   229440
aacatgcacg taagtattta catgagtgtg gtttacctaa agagcgcaca tatgtaactg   229500
gttctcctat ggcagaagtg ttacataaaa atttatctgc tattgagtct tcagatatcc   229560
atgaacgttt gggattgaaa aaaggaggtt atatcttact ttcagctcac cgtgaggaaa   229620
atattgatac agataaaaat tttatttctc tctttacagc aattaatcaa ttagctgaaa   229680
agtataatat gccaatctta tattcttgcc atcctagatc aaagaaaagg ctacaagaga   229740
gcggttttaa actagataaa cgtgtgattc agcatgagcc actaggattc catgactata   229800
attgtttaca gatgaatgca tttgttgtag tatctgattc gggaacttta ccggaagaaa   229860
gtagtttctt tactagtcaa ggttatcctt ttcccgctgt atgtattcgt acaagtacag   229920
aacgtcctga gtccttagat aaggcaggat ttattttggc aggcattgat gaaaattctc   229980
ttcttcaagc agttgaaact gctgttagct tggcacaaga tgaggatttt ggattaccgg   230040
ttccggatta tgttgaggaa aatgtctcta ctaaagttgt taagataata cagagctata   230100
cagggatagt ggataaaata gtttggagga aaagctgaat tgtatatttt taataaatca   230160
aaacgagatg attaattctt agtagaacaa gagtaaaatt gaacgtattt gatggaaatg   230220
tcttacttga tagtcgaggg atagccattc tatcggattt ttggcttgtt tttgcgcttc   230280
atgtttgata gaataaaggg ctctttgtca actgtagtgg gttgaagaaa agctaagctt   230340
gagaaaggac aaatttcgtc ctttcttttt tgatgttcag agcgataaaa atccgttttt   230400
tgaagttttc aaagtttcga aagtaaccgc ccaataacga agtctattga aaaatctcca   230460
gactagagaa ctcatatata gttcctaatc tggagatttc ttatttgcac ttttcttgta   230520
caactttagt ccacggtaaa taggcctcta aaacctcttt gtttacgaga gtttcctcgt   230580
ttggaagaca ttctagaaga taggatagat atttctcgct atttataatg gattgtaata   230640
agatatgaac aaatcgatta ggaaaggaaa attgatttat agaaatattt tagcagtcga   230700
tgcgtactgt tatagattca acgcactata attgatgacg tttagctgtt tccaacaaac   230760
tcataataat agctcttgct ttagctcctt caaaactttg agaaaataac caccctcgct   230820
tttttaaaaa taaccaccct cgttttttta aactgagctt aggctaaaag agtccactgg   230880
actcttttac tccgtcccat aaccaatgat ttaatggcgc gttcagctag attattggaa   230940
aggaccagat gtccgtcttt taaaatggtc ttaaaggttt cttcatactt gaggctgtat   231000
tcaattgccc ttcctagttt tgaacccgat aaaactgact gacgacggca ccaagcaaag   231060
aagtcttcca gtaggggttg gagatgttct tgacgtttct gtagccgttc atcagctggc   231120
aaagcctccc agtctctttc caaggaaaat aactgatcac aataggctaa acctttagct   231180
cctaaggatg atttatctgc ttgcttgggg ggcacttcaa aaaacttcct tctcacatgc   231240
gcccaacatc caacaagtgc agcttcttcc agttgacgat aagcttctag ctgttcgcag   231300
tttaccaagc ttagcgtcgc cttactccta aaccttggac tgctatcgca taggcagaac   231360
tagaggacta aagtcctaag ttactgccgc aacatatcac aatgaacata gccagaataa   231420
tctcctagga attcttgtac tactgaacca cttcgacact gatcatggtg gtaaagcgta   231480
atcccttgtt tctctgcttt acctgacaaa aaagtccaat agtaggtcag atggctatca   231540
ctctctagaa cccgatagga ggtttcatcc gcatgaagta agggctgagt caatagtctc   231600
tctcgcaaga ggttataaag gggctttagg aataggagct ttcacaagct tatccagatg   231660
attatctttt actcgttatg gacaatgcta tatggcataa atcaagtacc ttaaagattc   231720
cgactaatat tggctttgca tttattcctc catacacacc agagatgaac cccattgaac   231780
aagtgtggaa agagattcgt aaacgtggat ttaagaataa agcctttcga actttggaag   231840
atgtcatgaa tcaacttcaa gatgttatac aaggactgga gaaggaggtg ataaagtcca   231900
tcgttaatcg gagatggact agagtgcttt ttgaaagcag atgagtataa aaagaaagtc   231960
ctcatttcaa tagaaatcac gactttctga tggatttata gtaaaatgaa ataataacag   232020
gacaaatcga tcaggacagt aaaatcgatt tctaacaatg ttttagaagc agaggtgtac   232080
tattctagtt tcaatctact atatttttgg agtgatagaa aagcctttca tcagccaatc   232140
tacttgttca ggtgcgagag ctttgacatc cttttctgta ctgggccaag tcagtctgcc   232200
gttctcaaag cgtttatata gtagccaaaa tccttgacca tcccagtaaa ggactttaaa   232260
gcggtcttta cgtccaccac aaaagagaaa gatttgaccg gagaaaggat ccaattcaaa   232320
gtgggtttta acgagataag ccagtgaatc gattccttgt ctcatatcag ttttcccaca   232380
cacgagatag acctgcccta ggctagatag atgaattgtc atagagcaac accttatcca   232440
aaagctgttc tatcatttcg agattgagag attgaaaaaa acttacttca agcttgccaa   232500
tacgaatttt aagtagaata tcatttctct ttttagaatc aaaacgacga gattgtggaa   232560
tctctacagg aacaataggt tgtggcatta aaatatcctc caatatttac tttactaata   232620
gtatacagga ggagctccat gaatgataga taccttgtta tgacgcgctt acgatattca   232680
tattttttgc aaagatgttg tttgaaaaat aattttcaaa aattctgaaa attctgttga   232740
caactttctg aaaagagtct ataatggaga gaaagtttta aaggagaaaa tgatgaaaag   232800
ttcaaaacta tttgcccttg cgggcgtgac attattggcg gcgactactt tagctgcatg   232860
ctctggatca ggttcaagca ctaaaggtga gaagacattc tcatacattt atgagacaga   232920
ccctgataac ctcaactatt tgacaactgc taaggctgcg acacaaatat taccagtaac   232980
gtggttgatg gtttgctaga aaatgatcgc tacgggaact ttgtgccgtc tatggctgag   233040
gattggtctg tatccaagga tggattgact tacacttata ctatccgtaa ggatgcaaaa   233100
tggtatactt ctgaaggtga agaatacgcg gcagtcaaag ctcaagactt tgtaacagga   233160
ttaaaatatg ctgctgataa aaaatcagat gctctttacc ttgttcaaga atcaatcaaa   233220
gggttggatg cctatgtaaa aggggaaatc aaagatttct cacaagtagg aattaaggct   233280
ctggatgaac agacagttca gtacactttg aacaaaccag aaagcttctg gaattctaag   233340
acaaccatgg gtgtgcttgc gccagttaat gaagagtttt tgaattcaaa aggagatgat   233400
tttgccaaag ctacggatcc aagtagtctc ttgtataacg gtccttattt gttgaaatcc   233460
attgtgacca aatcctctgt tgaatttgcg aaaaatccga actactggga taaggacaat   233520
gtgcatgttg acaaagttaa attgtcattc tgggatggtc aagataccag caaacctgca   233580
gaaaacttta aagatggtag ccttacagca gctcgtctct atccaacaag tgcaagtttc   233640
gcagaacttg agaagagtat gaaggacaat attgtctata ctcaacaaga ctctattacg   233700
tatctagttg gtacaaatat tgaccgtcag tcctataaat acacatctaa gaccagcgac   233760
gaacaaaagg catcgactaa aaaggctctc ttaaacaagg atttccgtca ggctattgcc   233820
tttggatttg accgtacagc ctatgcctct cagttgaatg gacaaactgg agcaagtaaa   233880
atcttgcgta atctctttgt gccaccaaca tttgttcaag cagatggtaa aaactttggc   233940
gatatggtca aagagaaatt ggtcacttat ggggatgaat ggaaggatgt taatcttgca   234000
gattctcagg atggtcttta caatccagaa aaagccaagg ctgaatttgc taaagctaaa   234060
tcagccttac aagcagaagg agtccaattc ccaattcatt tggatatgcc agttgaccaa   234120
acagcaacta caaaagttca gcgcgtccaa tctatgaaac aatccttgga agcaacttta   234180
ggagctgata atgtcattat tgatattcaa caactacaaa aagacgaagt aaacaatatt   234240
acatattttg ctgaaaatgc tgctggcgaa gactgggatt tatcagataa tgtcggttgg   234300
ggtccagact ttgccgatcc atcaacctac cttgatatta tcaaaccttc tgtaggagaa   234360
agtactaaaa catatttagg gtttgactca ggggaagata atgtagctgc taaaaaagta   234420
ggtctatatg actacgaaaa attggttact gaggctggtg atgagactac agatgttgct   234480
aaacgctatg ataaatacgc tgcagcccaa gcttggttga cagatagtgc tttgattatt   234540
ccaactacat ctcgtacagg gcgtccaatc ttgtctaaga tggtaccatt tacaatacca   234600
tttgcattgt caggaaataa aggtacaagt gaaccagtct tgtataaata cttggaactt   234660
caagacaagg cagtcactgt agatgaatac caaaaagctc aggaaaaatg gatgaaagaa   234720
aaagaagagt ctaataaaaa ggctcaagaa gatctcgcaa aacatgtgaa ataactgttg   234780
caaaatataa gaaaggattt agtatttccc ttgaatgctg aatccttttt tacatttgta   234840
aagaaagatt ctaaaatgta cggaccccca aaagttggag cctctttttg tcagaataga   234900
gaaaattttt gttaatttta cttgtttcct attgctttct cagctattat ttgttatatt   234960
aaaagtataa ttatttttta tttatcagag ttaagcattg cactttcaga ggaaggagta   235020
ttttttaaaa agaaaatgta aacgtttgct caaaaatgaa aggatttaga agtttatgaa   235080
taaaggatta tttgaaaaac gttgtaaata tagtattcgg aaattttcat taggtgttgc   235140
ttctgttatg attggagctg cattctttgg gacaagtccg gttcttgcag atagcgtgca   235200
gtctggttcc acggcgaact taccagctga tttagctact gctcttgcaa cagcaaaaga   235260
gaatgatggg cgtgattttg aagcgcctaa ggtgggagaa gaccaaggtt ctccagaagt   235320
tacagatgga cctaagacag aagaagaact attagcactt gaaaaagaaa aaccggctga   235380
agaaaaacca aaagaggata aacctgcagc tgctaaacct gaaacaccta agacggtaac   235440
ccctgaatgg caaacggtag cgaataaaga gcaacaggga acagtcacta tccgagaaga   235500
aaaaggtgtc cgctacaacc aactatcctc aactgctcaa aatgataacg caggcaaacc   235560
agccctgttt gaaaagaagg gcttgaccgt tgatgccaat ggaaatgcaa ctgttgattt   235620
aaccttcaaa gatgattctg aaaagggcaa atcacgcttt ggtgtctttt tgaaatttaa   235680
agataccaag aataatgttt ttgtcggtta tgacaaggat ggctggttct gggagtataa   235740
atctccaaca actagcactt ggtatagagg tagtcgtgtt gctgctcctg aaacaggatc   235800
aacaaaccgt ctctctatca ctctcaagtc agacggtcag ctaaatgcca gcaataatga   235860
tgtcaatctc tttgacacag tgactctacc agctgcggtc aatgaccatc ttaaaaatga   235920
gaagaagatt cttctcaagg cgggctctta tgacgatgag cgaacagttg ttagcgttaa   235980
aacggataac caagaggggg taaaaacaga ggatacccct gctgaaaaag aaacaggtcc   236040
tgaagttgat gatagcaagg tgacttatga cacgattcag tctaaggtcc tcaaagcagt   236100
gattgaccaa gccttccctc gtgtcaagga atacagcttg aacgggcata ctttgccagg   236160
acaggtgcaa cagttcaacc aagtctttat caataaccac cgaatcaccc ctgaagtcac   236220
ttataagaaa atcaatgaga caacagcaga gtacttgatg aagcttcgcg atgatgctca   236280
cttaatcaat gcggaaatga cagtacgctt gcaagttgta gacaatcaat tgcactttga   236340
tgtgactaag attgtcaacc acaatcaagt cactccaggt caaaagattg atgacgaaag   236400
caaactactt tcttctatta gtttcctcgg caatgcttta gtctctgttt ctagtaatca   236460
aactggtgct aagtttgatg gggcaaccat gtcaaacaat acgcatgtca gcggagatga   236520
tcatatcgat gtaaccaatc caatgaagga tttggctaag ggttacatgt atggatttgt   236580
ttctacagat aagcttgctg ctggtgtttg gagtaactct caaaacagct atggtggtgg   236640
ttcgaatgac tggactcgtt tgacagctta taaagaaaca gtcggaaatg ccaactatgt   236700
aggaatccac agctctgaat ggcaatggga aaaagcttat aagggcattg ttttcccaga   236760
atacacgaag gaacttccaa gtgctaaggt tgttatcact gaagatgcca atgcagacaa   236820
gaacgttgat tggcaagatg gtgccattgc ttatcgtagc attatgaaca atcctcaagg   236880
ttgggaaaaa gttaaggata tcacagctta ccgtatcgcg atgaactttg gttctcaagc   236940
acaaaaccca ttccttatga ccttggatgg tatcaagaaa atcaatctcc atacagatgg   237000
tcttgggcaa ggtgttctcc ttaaaggata tggtagcgaa ggccatgact ctggtcactt   237060
gaactatgct gatattggta agcgtatcgg tggtgtcgaa gacttcaaga ccctaattga   237120
gaaggctaag aaatatggag ctcatctagg tatccacgtt aacgcttcag aaacttatcc   237180
tgagtctaaa tacttcaatg aaaaaattct ccgtaagaat ccagatggaa gctatagcta   237240
tggttggaac tggctagatc aaggtatcaa cattgatgct gcctatgacc tagctcatgg   237300
tcgtttggca cgttgggaag atttgaagaa aaaacttggt gacggtctcg actttatcta   237360
tgtggacgtt tggggtaatg gtcaatcagg tgataacggt gcctgggcta cccacgttct   237420
tgctaaagaa attaacaaac aaggctggcg ctttgcgatc gagtggggcc atggtggtga   237480
gtacgactct accttccatc actgggcagc tgacttgacc tacggtggct acaccaataa   237540
aggtatcaac agtgccatca cccgctttat ccgtaaccac caaaaagatg cttgggtagg   237600
ggactacaga agttatggtg gtgcagccaa ctatccactg ctaggtggct acagcatgaa   237660
agactttgaa ggctggcagg gaagaagtga ctacaatggc tatgtaacca acttatttgc   237720
ccatgacgtc atgactaagt acttccaaca cttcactgta agtaaatggg aaaatggtac   237780
accggtgact atgaccgata acggtagcac ctataaatgg actccagaaa tgcgagtgga   237840
attggtagat gctgacaata ataaagtagt tgtaactcgt aagtcaaatg atgtcaatag   237900
tccacaatat cgcgaacgta cagtaacgct caacggacgt gtcatccaag atggttcagc   237960
ttacttgact ccttggaact gggatgcaaa tggtaagaaa ctttctactg ataaggaaaa   238020
gatgtactac ttcaatacgc aggccggtgc aacaacttgg acccttccaa gcgattgggc   238080
aaagagcaag gtttaccttt acaagctaac tgaccaaggt aagacagaag agcaagaact   238140
aactgtaaaa gatggtaaaa ttaccctaga tcttctagca aatcaaccat acgttctcta   238200
tcgttcgaaa caaactaatc ctgaaatgtc atggagtgaa ggcatgcaca tctatgacca   238260
aggatttaat agcggtacct tgaaacattg gaccatttca ggcgatgctt ctaaggcaga   238320
aattgtcaag tctcaagggg caaacgatat gcttcgtatt caaggaaaca aagaaaaagt   238380
tagtctcact cagaaattaa ctggcttgaa accaaatacc aagtatgccg tttatgttgg   238440
tgtagataac cgtagtaatg ccaaggcaag tatcactgtg aatactggtg aaaaagaagt   238500
gactacttat accaataagt ctctcgcgct caactatgtt aaggcctacg cccacaatac   238560
acgtcgtgac aatgctacag ttgacgatac aagttacttc caaaacatgt acgccttctt   238620
tacaactgga gcggacgtct caaatgttac tctgacattg agtcgtgaag ctggtgatca   238680
agcaacttac tttgatgaaa ttcgtacctt tgaaaacaat tcaagcatgt acggagacaa   238740
gcatgataca ggtaaaggca ccttcaagca agactttgaa aatgttgctc agggtatctt   238800
cccatttgta gtgggtggtg tcgaaggtgt tgaagataac cgcactcact tgtctgaaaa   238860
acacaatcca tatacacaac gtggttggaa tggtaagaaa gtcgatgatg ttatcgaagg   238920
aaattggtca ctcaagacaa atggactagt gagccgtcgt aacttggttt accaaaccat   238980
cccacaaaac ttccgttttg aagcaggtaa gacctaccgt gtaacctttg aatacgaagc   239040
aggatcagac aatacctatg cttttgtagt cggtaaggga gaattccagt caggtcgtcg   239100
tggtactcaa gcaagcaact tggaaatgca tgaattgcca aatacttgga cagattctaa   239160
gaaagccaag aaggcaacct tccttgtgac aggtgcagaa acaggcgata cttgggtagg   239220
tatctactca actggaaatg caagtaatac tcgtggtgat tctggtggaa atgccaactt   239280
ccgtggttat aacgacttca tgatggataa tcttcaaatc gaagaaatta ccctaacagg   239340
taagatgttg acagaaaatg ctctgaagaa ctacttgcca acggttgcca tgactaacta   239400
caccaaagag tctatggatg ctttgaaaga ggcggtcttt aacctcagtc aggccgatga   239460
tgatatcagt gtggaagaag cgcgtgcaga gattgccaag attgaagctt tgaagaatgc   239520
tttggttcag aagaagacgg ctttggtagc agatgacttt gcaagtctta cagctcctgc   239580
tcaggctcaa gaaggtcttg caaatgcctt tgatggcaat gtgtctagtc tatggcatac   239640
atcttggaat ggtggagatg taggcaagcc tgcaactatg gtcttgaaag aaccaactga   239700
aatcacagga cttcgctatg ttccgcgtgg atcaggttca aatggtaact tgcgagatgt   239760
gaaacttgtt gtgacagatg agtctggcaa ggagcatacc tttactgcaa ctgattggcc   239820
aaataacaac aaaccaaaag atattgactt tggtaagaca atcaaggcta agaaaattgt   239880
ccttactggt accaagacat acggagatgg tggagataaa taccaatctg cagcggaact   239940
tatctttact cgtccacagg tagcagaaac acctcttgac ttgtcaggct atgaagcagc   240000
tttggttaag gctcagaaat taacagacaa agacaatcaa gaggaagtag ctagcgttca   240060
ggcaagcatg aaatatgcga cggataacca tctcttgacg gaaagaatgg tggaatactt   240120
tgcagattat ctcaaccaat taaaagattc tgctacgaaa ccagatgctc caactgtaga   240180
gaaacctgag tttaaactta gatctttagc ttccgagcaa ggtaagacgc cagattataa   240240
gcaagaaata gctagaccag aaacacctga acaaatcttg ccagcaacag gtgagagtca   240300
atctgacaca gccctcatcc tagcaagtgt tagtctagcc ctatctgctc tctttgtagt   240360
aaaaacgaag aaagactagt atttagtaaa acctcttaac aagattacgg aagcagtctc   240420
tatcttttcc aatgaggttt atagtacaga aaaagcctga gaagatgtct tctcaggctt   240480
ttgttaagca cataaataca atagtgctat gacaaaatca cccagaaaaa tctgggtgat   240540
aaatgttatg gttgtgctgg ttgaggattc tgattttgtt gatcaggggt tgtatttgat   240600
tgttgcgtat tattgttagg attggtagtc gtactattat ttgtgcttgg agtggttgag   240660
ctagactgtg aagttgaact atctgatgat gagcttgaac tttcagttga tgggggttgt   240720
tgtggagcag gtgagttcca cgtagaacga gcaccatttt taaatacgaa ttctccattt   240780
ctgtagagcc cctctggtat attccaatct tctggattgc ttccttcaga caggtaggtc   240840
atcatagagc ggtaaacttt ggcagcgacc gtaaggccat tgcctacaag tggtgtcaga   240900
cggttagaat agcctgtcca tacagccatt gaatatttac gcgtatagcc agcaaatagt   240960
tcatcaggtg ctacaaattg agaggtcttg atgtggtttt caatttcctc gtctgtatag   241020
ttagaggttc ctgttttacc agcctgaggg agccaagcaa gataggcatt tcgtccagtt   241080
ccataagtca agactgtttt catcatgtcg gtcatcatat aggctgtcgt ttccttcatg   241140
gcacgagttc cgacattaga gaactctttt tcactcccat cactaaagac gactttatgg   241200
atatacattg gtttatagta agttccacca tttgcaaagg cagcgtaagc agcagccatc   241260
ttttcactac ttgctccata ttttttgtct gattcggttg tgttacttga aatggcattt   241320
gagtagtgaa tacttgggta gtcgattcct agaccattta ggaaagtctt ggcgcggttg   241380
agtccgacct tgtttagagt ttccacggct gggacgtttc gcgattgttg cagggcgtat   241440
tgcaaggtga tgttgccaaa gtagccccta tcccagttat aaacaggagt atttgtccca   241500
gggtagttat agggctcatc gtgaacgata gtagcagttg aatcgtagac accgtactcc   241560
aaggcaggag catagtctgt gatcggtttc atagttgatc cccagtcgcg gtttgtttct   241620
actgcttggt taattccgaa ggaaacatta cttgactgat ggcgtgctcc tagctgggca   241680
atgactttac cgttagaaac atcaacaatg gtagaagcga cttgcaattc atcgtctgga   241740
taggcaacgt attcgtctgt attgtaaata tcccacagat gtttttgagc ttcttggtct   241800
acatttgtgt agacatccat cccagttgtg agtaggttat agcctgtttc ttcttcaact   241860
tgattgatga cttccttgag gtaattatcc atgtaagcag ggtaattact tgctgatttg   241920
agactttgta gtccatcagt aattggtgta ttgactgctt tctcatactg ttcagcagag   241980
atgtagcctt gatttttcat ttcagataag accaagtttc ggcggtcttg ggctgcttct   242040
ggatgtgaat aggggtcata ttggtttggt gcctgaggca ttccagccag caaggctaac   242100
tgaggtaaac ttaaattatt gaggtcttta ccatagtagt tttgagctgc tgtctgcatt   242160
ccatagttcc cattagacat gtagacctta tttatatagt aggtcaagat ttcttgcttg   242220
gttgcttttt gttctaactg aatcgctaac caagcttcct gagccttacg agaaatagtc   242280
tggtcggaag tcgaagttga aaagtaagtc aacttaatca actgttgggt gagagttgat   242340
ccaccttgga gggaattgct ttgcagattg cgcaagaaag ctcccaggat acggatggta   242400
tcaatccccc tgtggtcgaa gaagcgatgg tcttcgatag aaacgattgc cttaaccaaa   242460
tctgtgggaa tatcattagc ttgggcattg acgcggcgtt cagaacccaa gtcagcaatg   242520
agttgatttt tattgtcgta gattttacta gaagttgttg caactagttt actctcggat   242580
aggctaggag ccttgctaac gtagtagaaa aaaactcctc cgcctaagac aatggctgcg   242640
ataaccaagc ttaagaagct aatgctcaga tacttgatta ggcgcagaat cgttggtttg   242700
ttcatcttgt tttaccacct aataaatgtt ctttgataac attgagataa ggaatttgag   242760
ggaaggcacc agccttgatt tcatatccat attctcgaat atattcaagt ggcattgatt   242820
tttgtccctt atcttgatga tagaagcgaa tcaaatcgaa tgccggcaat aagtaggttt   242880
cttgctgaga agaaaagtga agaaggacaa agcagattcc ttgttgggca aggacttgtt   242940
ccatatgctg aatctgatgt ggatgaaaat ttttcatcgg aatcgcacgt ttttgttttg   243000
tttccttgac ttcaaagtcg atgtaatatc cattataaac gccagaatag tccgtcgttg   243060
aagcttgtcg aaaataggct tcaacaatct tggcacgact tcgttgtgga tagtccactt   243120
gtacgatttg aataggagtt ggtttcttat gtataacagc caagccctga gacaaatagt   243180
agtcgttggt agcattgatc atcttttcaa aagacattcc tcgatttgcg aaatttttgg   243240
gttgagaaag agatgtttgt cttttttgtg atgaaacttt atgtggatag ttgaccataa   243300
ttctccttat tggtacaata acatcacttt attataccat aatttgcaca gaaagggtta   243360
aaaatggcta cagctttggt tttaggctat tctgcttttg atttgggttt attttctgat   243420
aaggatcctc gtcttaaatt gattaaaaaa gcgatacgta aagatttaga ggctatggca   243480
gcagatgggg tgtcttggct tgtgtttaca gggagtttgg gttttgaata ttgggtttta   243540
gaggttgctc aggagatgaa aactgaatac ggtttccagt tggccaccat ttttgctttt   243600
gaaacccatg gggaaaattg gaatgaaggc aatcagatga aactgagtcg ctttaagcag   243660
gtagactttg tcaaatatgc ctatcctcgc tatgaacaca aggggcagtt aagagattac   243720
cagcagtttt tgctggaaaa cacgactagt tcctatcttt tttatgatga agaaaatgaa   243780
acaaaactag cttattttta ccaaaagatg aaaaatcaag aggactattt tataaagaga   243840
ttaacatttg atgaattaaa tgaacttgct gaaaattttt ccgaaaattg aagctttgac   243900
cttgattttt gtttgccttt ttttatataa taatactagc aagcgagaat ggagagagac   243960
atggcaagta ttattttttc agcgaaagat atttttgaac aagagtttgg acgtgaggtc   244020
cgtggctata ataaagtaga agttgacgag tttttagacg atgtcatcaa ggactatgaa   244080
acctatgctg ccttggtcaa gtcacttcgt caggaaattg cggatttgaa ggaagaatta   244140
actcgtaaac cgaaaccttc accagttcaa gcagaacccc ttgaagcggc aattacaagt   244200
tctatgacga attttgatat tttgaaacgc ctgaatagat tggaaaaaga agtttttggt   244260
aaacaaattt tagataactc agatttttaa gtagttattt gagatgtgca atttttggat   244320
aatcgcgtga ggagaattgt ttctcatgag gaaagtccat gctagcacag gctgtgatgc   244380
ctgtagtgtt tgtgctaggc gaaaccataa gcctagggac gagaaatcgt tacggcagtt   244440
gaaatggcta agtccttgga taggccagag taggcttgaa agtgccacag tgacggagtc   244500
tttctggaaa cagagagagt ggaacgcggt aaacccctca agctagcaac ccaaattttg   244560
gtcggggcat ggagtacgcg gaaacgaacg tagtattctg actgctatca gctagagctg   244620
ttagtggtag acagatgatt atcgaaggaa gtggtcctag tcacttctgg aacaaaacat   244680
ggcttataga aaattgcata taggttgggg ctgagaaatt ttctcaacct cattttttaa   244740
agtggacata tagaaaggtc ttgcaagact gtaacatgaa aaaagaattt aatttaattg   244800
caactgtggc agcagggctt gaggctgtcg ttggtcgtga agtgcgagag ttgggctacg   244860
attgtcaggt tgaaaatgga cgtgttcgtt ttcaaggaga cgtgagagct attatcgaaa   244920
ccaacctttg gcttcgggca gcagatcgta tcaaaattat cgtaggaacg ttcccagcta   244980
agacttttga agagctattt cagggagttt tcgctttgga ttgggaaaat tatttaccac   245040
ttggagctcg gttcccgatt tcaaaagcta aatgtgttaa gtccaaactt cacaatgagc   245100
ccagtgttca ggctatttct aagaaagctg ttgtcaagaa attgcagaaa cactatgctc   245160
gcccagaagg ggttcctctg atggagaatg gcccagagtt taagattgag gtctctattc   245220
tcaaagatgt ggcaactgtc atgattgata cgaccgggtc tagcctcttt aaacgtggtt   245280
atcgtaccga aaaaggtggc gctcctatca aggaaaatat ggcagcagcc attttacaac   245340
tttctaactg gtatccagac aagcctttga ttgatccgac ctgtggttcg gggactttct   245400
gtattgaggc agttatgatt gctagaaaga tggcgccagg tcttcgtcgc tcttttgcat   245460
ttgaggaatg gaactggatc agcgatcgct tgattcaaga agtgcgcaca gaagcggcta   245520
aaaaagtaga ccgtgagctt gagctggata tcatgggctg tgatattgat gctcgcatgg   245580
tggaaattgc taaggccaat gctcaggtag ctggtgttgc aggagacatt acttttaagc   245640
agatgcgcgt gcaggattta cgttccgata aaatcaatgg agtaatcatt tccaatccgc   245700
cttatggtga acgtttgtca gatgatgcag gggtgaccaa gctctatgct gagatggggc   245760
aagtatttgc accgctgaaa acttggagca aatttatcct gactagtgat gaagcttttg   245820
aaagcaagta tggtagccaa gcagataaga agcgtaagtt atacaacgga accttgaaag   245880
tggatctata tcaatatttt ggtcagcgtg tcaaacggca agaggtaaaa tagaaaggga   245940
tactcatgag taaaaaaaga cgaaatcgtc ataaaaaaga aggtcaagaa ccgcaatttg   246000
attttgatga agcaaaagag ctaacagttg gtcaagctat tcgtaaaaat gaagaagtgg   246060
aatcaggagt cttgcctgag gattccattt tggacaagta tgttaagcaa cacagagatg   246120
aaattgaggc ggataagttt gcgactcgtc aatacaaaaa agaggagttc gttgaaactc   246180
agagtctgga tgatttaatt caagagatgc gtgaggctgt agagaagtca gaagcttctt   246240
cggaggaagt tccatcttct gaagacatct tactaccctt gcctctggac gatgaggagc   246300
aaggcttgga tcctctattg ctagatgatg aaaatccaac agaaatgact gaagaagtgg   246360
aagaggagca aaacctttct cgtctggatc aagaggactc agaaaagaaa agtaaaaaag   246420
gctttatttt gaccgttttg gcgcttgtat cagtaattat ttgtgtcagt gcttattatg   246480
tctaccgtca agtggctcgt tcgactaagg aaattgaaac ttctcaatca actacagcca   246540
atcaatcgga tgtggatgat tttaatacac tttatgacgc cttttacaca gatagcaata   246600
aaacggcttt gaaaaatagc cagtttgata aactgagtca actcaagact ttacttgata   246660
agctggaagg tagtcgtgaa catacgcttg ccaaatctaa atatgatagt ctagcaacgc   246720
aaatcaaggc tattcaagat gtcaatgctc aatttgagaa accagctatt gtggatggtg   246780
tgttggatac caatgccaaa gccaaatcgg atgctaaatt tacggatatt aaaactggaa   246840
atacggagct tgataaagtg ctagataagg ctatcagtct tggtaagagc cagcaaacaa   246900
gtacttctag ctcaagttca agtcaaacta gcagctcaag ttcaagtcaa gcaagttcaa   246960
atacgactag tgagccaaaa ccaagtagtt caaatgagac tagaagtagt cgcagtgaag   247020
tcaatatggg tctctcgagt gcaggggttg ctgttcaaag aagtgccagt cgtgttgcct   247080
ataatcagtc tgctattgat gatagtaata actctgcctg ggattttgcg gatggtgtct   247140
tggaacaaat tctagcgact tcacgttcac gtggctatat cactggagac caatatatcc   247200
ttgaacgtgt caatatcgtt aacggcaatg gttattacaa cctctacaag ccagatggaa   247260
cctatctctt tacccttaac tgtaagacag gctactttgt cggaaatggc gctggtcatg   247320
cggatgactt agattactaa gcagtcgtta caaaattctt tcttttcaaa agtaaaaatg   247380
ataaaataaa acaaatgaaa caagaggagt gtcaaatgac aaaagctaac tttggtgtcg   247440
taggtatggc cgtaatgggt cgtaaccttg cccttaatat tgaatctcgt ggttacacag   247500
ttgctatcta caaccgtagt aaagaaaaaa cggaagatgt gattgcttgc catcctgaaa   247560
agaactttgt accaagctat gacgttgaaa gttttgtaaa ctcaatcgaa aaacctcgtc   247620
gtatcatgct gatggttcaa gctggacctg gtacagatgc tactatccaa gcccttcttc   247680
cacaccttga caagggtgat atcttgattg acggaggaaa tactttctac aaagatacca   247740
tccgtcgtaa tgaagaattg gcaaactctg gtatcaactt tatcggtact ggggtttctg   247800
gtggtgaaaa aggtgccctt gaaggtcctt ctatcatgcc tggtggacaa aaagaagcct   247860
acgaattggt tgcggatgtt cttgaagaaa tctcagctaa agcaccagaa gatggcaaac   247920
catgtgtgac ttacatcggt cctgatggag ctggtcacta tgtgaaaatg gttcacaatg   247980
gtattgagta cggtgatatg caattgatcg cagaaagcta tgacttgatg caacacttgc   248040
taggcctttc tgcagaagat atggctgaaa tctttactga gtggaacaag ggtgaattag   248100
acagctactt gattgaaatc acagctgata tcttgagccg taaagacgat gaaggccaag   248160
atggaccaat cgtagactac atccttgatg ctgcaggtaa caagggaact ggtaaatgga   248220
ctagccaatc atctcttgac cttggtgtac cattgtcact gattactgag tcagtgtttg   248280
cacgctacat ttcaacttac aaagaagaac gtgtacatgc tagcaaggtg cttccaaaac   248340
cagctgcctt caactttgaa ggagacaagg ctgaattgat tgaaaagatc cgtcaagccc   248400
tttacttctc aaaaatcatt tcatacgcac aaggatttgc tcaattgcgt gtagcctcta   248460
aagaaaacaa ctggaacttg ccatttgcag atatcgcatc tatctggcgt gatggctgta   248520
tcatccgttc tcgtttcttg caaaagatta cagatgctta caaccgcgat gcagatcttg   248580
ccaaccttct tttggacgag tacttcttgg atgttactgc taagtaccaa caagcagtac   248640
gtgatatcgt agctcttgcg gttcaagcag gtgtgccagt gccaactttc tcagcagcta   248700
ttacttactt tgatagctac cgttcagctg accttccagc taacttgatc caagcacaac   248760
gtgactactt tggtgctcac acttaccaac gtaaagacaa agaaggaacc ttccactact   248820
cttggtatga cgaaaaataa gtaggtcagc catggggaaa cggattttat tacttgagaa   248880
agaacgaaat ctagctcatt ttttaagttt ggaactccag aaagagcagt atcgggttga   248940
tctggtagag gaggggcaaa aagccctctc catggctctt cagacagact atgatttgat   249000
gttattgaac gttaatctgg gagatatgat ggctcaggat tttgcagaaa aattgagccg   249060
aactaaacct gcctcagtca tcatgatttt agatcattgg gaagacttgc aagaagagct   249120
ggaagttgtt cagcgttttg cagtttcata catctataag ccagtcctta tcgaaaatct   249180
ggtagcgcgt atttcggcga tcttccgagg tcgggacttc attgatcaac actgcagtct   249240
gatgaaagtt ccaaggacct accgcaatct taggatagat gttgaacatc acacggttta   249300
tcgtggtgaa gagatgattg ctctgacacg ccgtgagtat gaccttttgg cgacacttat   249360
gggaagcaag aaagtattga ctcgtgagca attgttggaa agtgtttgga agtatgaaag   249420
tgcgaccgag acaaatatcg tagatgtcta tatccgctat ctacggagca agcttgatgt   249480
taaaggccaa aaaagctaca ttaaaactgt gcgtggtgtt ggatatacca tgcaagaata   249540
gaaaagcagt tgcagttgtg taactgcttt tttgaggagt ttttatatat tgacatacaa   249600
tctagttttt actacaatcg ttttaggagg atatataaaa tgaagctttt gaaaaaaatg   249660
atgcaagtcg cattagcagt ctttttcttt ggtttgctag ctacaaatac ggtatttgcg   249720
aataccacag gtggccgatt tgttgataag gataatagaa aatattatgt aaaagatgat   249780
cataaagcaa tctattggca taaaatagac ggtaaaactt actattttgg tgatattgga   249840
gagatggttg tcggttggca atacttagaa attcctggaa caggttatcg tgataattta   249900
ttcgataacc aaccagttaa tgaaattggc cttcaggaga agtggtacta ttttggacaa   249960
gatggtgctt tgctagaaca aacagataaa caagtactag aggcaaaaac gtctgaaaat   250020
acaggaaaag tatacggtga acaatatcct ctatctgctg aaaagagaac ttattatttt   250080
gataataatt atgctgtaaa gacaggctgg atttatgaag agggtcattg gtattattta   250140
aataagctag gaaattttgg cgatgattct tacaatccac taccaattgg tgaagttgct   250200
aagggttgga ctcaagattt tcatgttact attgacattg atagaagcaa acctgctcca   250260
tggtactacc tagatgcttc aggtaagatg cttacagatt ggcaaaaagt aaacggaaaa   250320
tggtattatt ttggctcctc tggttctatg gcaacaggtt ggaaatatgt acgaggcaaa   250380
tggtattact tagataataa aaatggtgat atgaaaacag gatggcaata ccttggtaac   250440
aagtggtact acctccgttc atcaggagct atggtaactg gctggtatca agatggttca   250500
acttggtact atttagatcc ttctaatgga gatatgaaaa taggttggac aaaagtaaat   250560
ggaaaatggt attatctcaa ttcaaatgga gcaatggtta caggtagcca aactatcgat   250620
ggtaaagttt ataatttcgc ctcatctggt gagtggattt aatattggag ggtatataga   250680
tgaaaatttt gaaaaaaact atgcaagttg gactgacagt atttttcttt ggtttgctag   250740
ggaccagtac agtatttgca gatgattctg aaggatggca gtttgtccaa gaaaacggaa   250800
gaacctacta caaaaagggg gacctcaaag aaacctactg gcgagtgatt gatggtaagt   250860
actattattt tgattctcta tctggagaga tggttgtcgg ctggcaatat atcccgtttc   250920
catctaaagg tagtacaatt ggtccttacc caaatggtat cagattagaa ggttttccaa   250980
agtcagagtg gtactacttc gataaaaatg gagtgctaca agagtttgtt ggttggaaaa   251040
cattagagat taaaactaaa gacagtgttg gaagaaagta cggggaaaaa cgtgaagatt   251100
cagaagataa agaagagaag cgttattata cgaactatta ctttaatcaa aatcattctt   251160
tagagacagg ttggctttat gatcagtcta actggtatta tctagctaag acggaaatta   251220
atggagaaaa ctaccttggt ggtgaaagac gtgcggggtg gataaacgat gattcgactt   251280
ggtactacct agatccaaca actggtatta tgcaaacagg ttggcaatat ctaggtaata   251340
agtggtacta cctccgttcc tcaggagcaa tggccactgg ctggtatcag gaaggtacca   251400
cttggtatta tttagaccac ccaaatggcg atatgaaaac aggttggcaa aaccttggga   251460
acaaatggta ctatctccgt tcatcaggag ctatggcaac tggttggtat caagatggtt   251520
caacttggta ctacctaaat gcaggtaatg gagacatgaa gacaggttgg ttccaggtca   251580
atggcaactg gtactatgct tatagctcag gtgctttggc agtgaatacg accgtagatg   251640
gctattctgt caactataat ggcgaatggg ttcggtaatg acagggcgct tataattata   251700
ttagaacact cgcttaatca aagaagtgac tttgttgtac ttgacctgac gattggggag   251760
attaaaagca tgtgaaatct acacatgctt tttcgttagt tatgagtgtt gaacttgact   251820
aaccattgac aaaagataag agcaattaaa ataagataca aaaatatcaa tgctaactgc   251880
accgaaacgc ccgatgctat ggatagggct aatagggaga gcagggacgg ggcgagaatg   251940
tccactgtgc tcagagcaga gcccaccgtc cccatcttgt cactggggat atgggcaaag   252000
acagctgctt gtaggcgagg gctgagaatg ccgataatcg tagaactgat gaaactggtc   252060
atgaaaatta cgatataggc ttgacaaagg atactagtta ttagagtcaa tagggaaatc   252120
tcacagaaaa ccaagaggtg cgtgaaacgg atatttttaa atagattact gctggtcata   252180
ttgccaagga tagctccaca agacatgatg atggagagca gggcgaggag ttgcccaatg   252240
ctcagttgtg ctagtgtctg ttggatgaag cggagggcaa tcagccgagg ggacacatcc   252300
aagatggcaa tcatactggt cgtcagaaac agtagtatga cggtatcttt taacctcagg   252360
agcacagcca gcgactgttt aagatgttga aaatatttct taaaactcag tgctgtatgt   252420
gacatttcaa ttcttttttc aacctcatac aaggtatgtc gaataacata caggcccaaa   252480
aaggcaatga caaaagtcag agtgttgata agggaaatag tttgaatact tataacattg   252540
ataaggaatg cgccagccag attggcgaca atacggacaa ccctcatcag agactgcctg   252600
aaccccatgg catcatgcag gtcgtcctta attacactga tgtagagggc gttcatcatg   252660
taggcagaca ggtagctcaa ggtgtcagag atgaggttga tgatgacaat cataatgact   252720
gaaactaatg aaaagggcga caagacgaga aatactgtca aaatagcgta gagcaggatt   252780
ttgattttgg caatccagag tgcgtgtttg actctatttt cttgaaaatc tcctagaatc   252840
ccgagaaaga gttgcgatag taggggaacc atctctgaaa tggaaatcag taaaatcgct   252900
agcggagcga aattgtactg agccacataa ttgataatgg cgaggtagaa aatactgtcg   252960
ccgaatgatg aaaaacagct gtttagcagc aactgtctat atatgttgtt tgtccaaaat   253020
aatttcatac ttttctcctt atgtctgcac atcgaatggg aatttattat ttaatagaca   253080
ccaatatacc ccatgcttcc tattccgaag tcaaacaaat ctgctttacc actatctcct   253140
tgaaacatca gtaaaccgtg atcatctcgt tcagaacatg ctaaaattac ctgttggatt   253200
tttttcatca gtaatttgtt ttgattgtag acagtggttt gtagtaagct agttattccg   253260
tggcaatatc ctgtcatcat ttttagatga tggttaaaaa caaattcttg atatttacta   253320
ataatatctt tgtttccgtc acaatcgtac atacaaagat ataagattat tccggaaatt   253380
cctttgcacc aagaaagttg taaatttcct aaattttcag tattagaagt aactttttct   253440
aataattttt ttaattcagt atggaatgta tggagatcat tataaaacat agaaggttct   253500
aagactttag aataggcaaa taaagcatat gcaattccac aatatccatg agcaaagcta   253560
tagtctaaaa tgctttcttt ggctgtatct ctttgtagga aataatgata aatttcccct   253620
atactattgt ggatgaaaat tttaagagta ttgtcattgg taaattgata gtattttatt   253680
aatgataata ggacaccaga ttttcccaat gcaaagtcta tttcctctag agtatcataa   253740
ttctctatta attttttagc ggtgacgttt gctaattgta gatagtattg atttttactg   253800
atagaaaata aatgtaggag taaccataga tagcctgcat caccaaatag cagtgagtat   253860
tgatattcat atgtgtgtgt cgttctaatt gtcactgcct tcttgatgat agagagtatt   253920
ttagaatcca gttctggggg gtacaattta tttagaggaa acagtagtcc agctattccg   253980
tgttggaatg ataaattact tacgaaattt ccaaattctg ttgaagaagt gatccttcct   254040
tcagaattta cagttttatc tagtaaaaat tgtagaacac tattacattc tgttttgtaa   254100
tcatatttat gttcctctat ttttttaatt ttgactaaat tatttgtttg acttaaattt   254160
agtagacatt gtaaccaaaa tagttgctca tctgtgagct gaccttgagt atgtgatagt   254220
tctagtaatt gaataggatc ctttagttag attcaatcaa tctataacac aacaacataa   254280
taatactttt aggataactt atcaaatatt atagtaaaat gagataataa caggataaat   254340
cgatcaggac agtcaaatcg atttctaaca atattttaga agtagaggtg tactattcta   254400
gtttcaatct actatagtat atatttttac atcttgaatt gtcaaattaa gtgcataact   254460
ttcccgtagc atacttcata aggcgttttc cacttaagaa attttcgtgg tcgattattt   254520
agaacctgta ttcacaaaaa aatgttaagc tagagttatg atacgcaaag catatgatac   254580
tgatttaaac gatcaagaat gggcgaagat tgaaccctat ttctccaaac accgcaccta   254640
taaatggccg aaacgagtac ttgttaatga gactttgtac gtcactaaaa caggttgtca   254700
atggcgcatg ctccctcacg actttcctct ttacttaatg gtatggagtt tctttcgtcg   254760
ttctatgacg acaggttggt tccaggtcaa tggcagatgg tactacgctt atagcgctca   254820
ggtgccttgg cagtgaatac gaccgtagat ggctattctg tcaactataa tggcgaatgg   254880
gttcaataat gaaagaagcg attgtgaatg gaaacaatcg ctttttttgt gaaaatataa   254940
taaaatagat aggaaagaat taatacttgt atgaaaaata agacgttttt tcgtctagta   255000
aaaggaaaaa atgacaaaaa aagttggtgt cggtcaggca catagtaaga taattttaat   255060
aggggaacat gcggtcgttt acggttatcc tgccatttcc ctgcctcttt tggaggtgga   255120
ggtgacctgt aaggtagttc ctgcagagag tccttggcgc ctttatgagg aggatacctt   255180
gtccatggcg gtttatgcct cactggagta tttgaatatc acagaagcct gcattcgttg   255240
tgagattgac tcggctatcc ctgagaaacg ggggatgggt tcgtcagcgg ctatcagcat   255300
agcggccatt cgtgcagtat ttgactacta tcaggctgat ctgcctcatg atgtactaga   255360
aatcttggtc aatcgagctg aaatgattgc ccatatgaat cctagtggtt tggatgctaa   255420
gacctgtctt agtgaccaac ctattcgctt tatcaagaac gtaggattta cagaacttga   255480
gatggattta tccgcctatt tggtgattgc cgatacgggt gtttatggtc atactcgtga   255540
agccatccaa gtggttcaaa ataagggcaa ggatgcccta ccgtttttgc atgccttggg   255600
agaattaacc cagcaagcag aagttgcgat ttcacaaaaa gatgctgaag gactgggaca   255660
aatcctcagt caagcgcatt tacatttaaa agaaattgga gtcagtagcc ctgaggcaga   255720
ctttttggtt gaaacgactc ttagccatgg tgctctgggt gccaagatga gcggtggtgg   255780
gctaggaggt tgtatcatag ccttggtaac caatttgaca cacgcacaag aactagcaga   255840
aagattagaa gagaaaggag ctgttcagac atggatagag agcctgtaac agtacgttcc   255900
tacgcaaata ttgctattat caaatattgg ggaaagaaaa aagaaaaaga gatggtgcct   255960
gctactagca gtatttctct aactttggaa aatatgtata cagagacgac cttgtcgcct   256020
ttaccagcca atgtaacagc tgacgaattt tacatcaatg gtcagctaca aaatgaggtc   256080
gagcatgcca agatgagtaa gattattgac cgttatcgtc cagctggtga gggctttgtc   256140
cgtatcgata ctcaaaacaa tatgcctacg gcagcgggtc tgtcctcaag ttctagtggt   256200
ttgtccgccc tggtcaaggc ttgtaatgct tatttcaagc ttggattgga tagaagtcag   256260
ttggcacagg aagccaaatt tgcctcaggt tcttcttctc ggagttttta tggaccacta   256320
ggagcctggg ataaggatag tggagaaatt taccctgtag agacagactt gaaactagct   256380
atgattatgt tggtgctaga ggacaagaaa aaaccaatct ctagccgtga cgggatgaaa   256440
ctttgtgtgg aaacctcgac gactttcgac gactgggttc gtcagtctga gaaggactat   256500
caggatatgc tgatttatct caaggaaaat gattttgcca agattggaga attaacggag   256560
aaaaatgccc tggctatgca tgctacgaca aagactgcta gtccagcctt ttcttatctg   256620
acggatgcct cttatgaggc tatggccttt gttcgccagc ttcgtgagaa aggagaggcc   256680
tgctacttta ccatggatgc tggtcccaat gttaaggtct tctgtcagga gaaagacttg   256740
gagcatttat cagaaatttt cggtcatcgt tatcgcttga ttgtgtcaaa aacaaaggat   256800
ttgagtcaag atgattgctg ttaaaacttg cggaaaactc tattgggcag gtgaatatgc   256860
tattttagag ccagggcagt tagctttgat aaaggatatt cccatctata tgagggctga   256920
gattgctttt tctgacagct accgtatcta ttcagatatg tttgatttcg cagtggactt   256980
aaggcctaat cctgactata gcttgattca agaaacgatt gctttgatgg gagacttcct   257040
cgctgttcgt ggtcagaatt taagaccttt ttctctagaa atctgtggca aaatggaacg   257100
agaagggaaa aagtttggtc taggttctag tggcagcgtc gttgtcttgg ttgtcaaggc   257160
tttactggct ctgtatgatg tttctgttga tcaggagctc ttgttcaagc tgactagcgc   257220
tgtcttgctt aagcgaggag acaatggttc catgggcgac cttgcctgta ttgtggcaga   257280
ggatttggtt ctctaccagt catttgatcg ccagaaggtg gctgcttggt tagaagaaga   257340
aaacttggcg acagttctgg agcgtgattg gggcttttca atttcacaag tgaaaccaac   257400
tttagaatgt gatttcttag tgggatggac caaggaagtg gctgtatcga gtcacatggt   257460
ccagcaaatc aagcaaaata tcaatcaaaa ttttttaact tcctcaaaag aaacggtgac   257520
ttctctggta gaagccttgg aacaggggaa atcagaaaag attatcgatc aagtagaagt   257580
agccagcaag cttttagaag gcttgagtac agatatttac acgcctttgc ttagacagtt   257640
gaaagaagcc agtcaagatt tgcagaccgt tgccaagagt agtggtgctg gtggtggtga   257700
ctgtggcatc gccctgagtt ttgatgcgca atcaaccaaa accttaaaaa atcgttgggc   257760
cgatctgggg attgagctct tatatcaaga aaggatagga catgacgaca aatcgtaagg   257820
acgagcatat cctctatgcc cttgagcaga aaagttccta taatagcttt gatgaggtgg   257880
agctgattca ttcttccttg cctctttaca atctggatga aatcgatctt tcgacagagt   257940
ttgctggtcg aaagtgggac tttccttttt atatcaatgc catgactggt ggaagtaata   258000
agggaagaga aatcaatcaa aagctggctc aggtggcgga atcctgtggt attttatttg   258060
taacgggttc ttatagcgca gccctcaaaa atccaacgga tgattctttt tctgtcaagt   258120
ctagtcatcc caatctcctc cttggaacca atattggatt ggacaagcct gtcgagttag   258180
gacttcagac tgtagaagag atgaatcctg ttctattgca agtgcatgtc aatgtcatgc   258240
aggaattact catgcccgag ggagaaagga agtttagaag ctggcaatcg catctagcag   258300
attatagcaa gcaaattccc gttcctattg tcctcaagga agtgggcttt ggaatggatg   258360
ccaagacaat cgaaagagcc tatgaattcg gtgttcgtac agtggaccta tcgggtcgtg   258420
gtggcaccag ctttgcctat atcgaaaacc gtcgtagtgg ccagcgtgat tacctcaatc   258480
aatggggtca gtctaccatg caggcccttc tcaatgccca agaatggaaa gataaggtcg   258540
aactcttggt tagtggaggg gttcggaatc cgctggatat gattaagtgc ttggtttttg   258600
gtgctaaggc tgtgggattg tcacgaaccg ttctggaatt ggttgaaacc tacacagttg   258660
aagaagtgat tggcattgtc caaggctgga aagcagatct acgcttgatt atgtgttccc   258720
ttaactgtgc caccatagca gatctacaaa aagtagacta tcttctttat ggaaaattaa   258780
aagaagcaaa ggatcagatg aaaaaggcgt aaccagcgcc ttttttccat cctcagactg   258840
aggtgacttt tttgaattgt gataaaatag aagggagagg atgaacctat gagaaaattt   258900
aaaatctttt tatttatcga agcctgtctt ctgacaggag ctctgatttt gatggtatca   258960
gagcattttt cgcgttttct gctgatacta ttcctctttt tgcttttgat tcgctactac   259020
actggtaaag agggaaataa tcttctttta gtagcggcaa ccattctctt ctttttcatc   259080
gttatgctca atccttttgt gattctagct atttttgttg cggttatcta tagcctcttt   259140
cttctttacc cgatgatgaa ccaggaaaaa gagcagacca atttggtttt tgaagaggtc   259200
gtgacggtta agaaggagaa aaatcgttgg tttggaaatc ttcatcattt ttcaagctac   259260
cagacttgcc aattcgatga tatcaatctc tttcgcttca tgggcaagga cactattcat   259320
ctggagaggg tcatcttaac caatcatgac aatgtcatta tcctcagaaa gatggtagga   259380
acgaccaaaa tcatcgtacc tgtagatgtg gaagtcagtc tcagcgttaa ctgtctctat   259440
ggggatttga tttttttcaa ccagcccaag cgagccctcc gcaatgaaca ctatcatcaa   259500
gaaacaaaag actatctcaa gagtaacaag agtgtcaaga ttttcttgac cactatgatt   259560
ggtgatgtgg aggtggttag aggatgaaaa aacaagccta tgtcattatt gctctcacct   259620
ccttcctatt tgtctttttt ttctcccaca gcttgctgga aatacttgat tttgactggt   259680
ctatcttttt gcacgatgtc gaaaaaacag aaaaatttgt ctttttattg ttggttttca   259740
gcatgtccat gacctgtctc ttagccctgt tttggcgagg gatcgaagag ctttctctaa   259800
gaaaaatgca ggctaatctc aagcgtttat tagcagggca agaagtggtt caggttgcag   259860
atccagattt ggatgccagt ttcaagtcct tatcaggtaa acttaacctt ttgacagagg   259920
ctcttcaaaa agctgaaaat cagagccttg ctcaggaaga ggaaatcatc gagaaggaac   259980
ggaagcgaat tgctcgggat ttgcacgata cagtcagtca ggagttgttt gcggcccaca   260040
tgattttatc gggtatcagt cagcaggctt tgaaattgga tagagaaaag atgcagaccc   260100
agttgcagag tgtcacagct attttagaaa cagcccagaa ggatttgcgg gttttgctct   260160
tgcatttgcg accagttgaa ctggagcaga agagcttgat agaagggatt caaattcttt   260220
taaaagagct tgaggacaag agtgatctta gggttagtct caagcagaat atgacgaaat   260280
tgcctaagaa aatcgaggag catatcttcc gtatcctgca agagttgatt agcaataccc   260340
tccgccatgc ccaggcatct tgcctagatg tctacctcta tcagacagat gttgaattgc   260400
aactgaaggt ggtggacaat gggattggtt tccagttagg gagcttagac gacttgagtt   260460
atggactgcg aaatatcaag gagcgggttg aagatatggc tggaacagtt caactcttga   260520
cagctcccaa gcaagggctg gcggttgata tccgtattcc cctgttagat aaggaatgat   260580
aaaggagtaa agatgaaaat tttactagta gatgaccatg aaatggtccg attgggcttg   260640
aaaagctact ttgacctcca agacgatgta gaagttgtgg gtgaggcgtc caacgggtct   260700
caagggattg acttggcctt ggaactgcgt ccagatgtca ttgtcatgga tattgtcatg   260760
cctgagatga atgggattga cgcgacctta gcaatcctta aagaatggcc tgaagccaag   260820
attttgattg tgacctctta tttggacaat gaaaaaatca tgccagtctt agatgctggt   260880
gccaaaggct atatgctcaa gacttctagt gcagatgaat tgcttcatgc cgtcagtaag   260940
gtagctgctg gcgagctggc cattgagcaa gaggttagca agaaggttga ataccaccgc   261000
aatcatatgg aacttcatga agaattgact gcgcgtgagc gagatgttct ccaactcatc   261060
gccaagggct acgaaaatca gcgcatcgca gatgacctct ttatctctct caagacggtc   261120
aagacccacg tgtccaatat tcttgccaaa cttgaagtca gcgatcgtac ccaggcggct   261180
gtctatgcct ttcagcacca tttggtgggg caagaggagt tttagatgag tttagcagat   261240
ttacttgagg agctagaagc agcaaaagac tctaaaaaag caaggtccat ggaagcctat   261300
atgcgccatc aattttcttt tctaggtatt gcggtgcctg aaagaaataa actctataaa   261360
atattttcca gaagcgaaaa aaacaaagat tatcgattgg gattttgcag acacttgctg   261420
ggaaaaggat cctagaaaat accaatatgt ggctgctaac tatttgaaag caatgcagtc   261480
ttatctaaag gaaaccgatt tgcctaagct agagcagtta gtcgtgacaa aatccttgtg   261540
ggacacggta gatatcctag atcgagtagt agggagtttg gtgtatgaac accctgaact   261600
agaagaaata atcttaatac tcttcgaaaa tctcttcaaa ccacgtcagc tctatctgca   261660
acctcaaaac agtgttttga gcaacctgcg gctagcttcc tagtttgctc tttgattttc   261720
attgagtata aaatggagcc tatcagataa tatctggctg agacgtgtcg ctattgacca   261780
ccagttgtta agaaaagaga agaccaatac tcaattaatg gaaaagattc tccttcataa   261840
cttgaaccaa acagaatttt ttatcaataa agccattggc tggactctgc gagactactc   261900
caaaacgaat cccacttggg taacatgctt tattgagaaa aacaaggaaa gaatggctga   261960
acttagtatc aaagaagcaa gcaagtacct ctagcgtgat tgaaaagcgc agtcattaat   262020
tgaaaagttt acctgtttat gtgataatgg agggtattta aagaaggtgg tagatttctt   262080
gattctatag tagattaaga aatttagaat agtacgctat aattacatta ggaggataca   262140
ataatgaaga aaactgttta taaaaaattg ggtatttcaa ttattgcgag tactttattg   262200
gctagccagt tatcgacagt atctgctttg agtgttattt ctagtacagg tgaagaatat   262260
gaggtaagtg agacactaga aaaaggtcca gagtctaatg attcttcatt atctgagatt   262320
tcaccaacgt atggttcata ctaccaaaag caatcagaag tattatcggt aatgatgatt   262380
tgattaaaat tgataatact ttacagtatc cgtattcgac ttcagctatg gttttatcta   262440
agtattatgg agtagccgat ggaatgaatg tagaagggag gggaagtgcg aattttatta   262500
aagataatgt gttaattaca gcggctcaca actactacag acatgactat gggaaagaag   262560
cggatgatat ttatgttctt ccggctgtta gtccaagtca agaaccattt ggaaagatca   262620
aagtaaagga agttcgttat ttgaaggaat ttagaaattt aaattctaag gatgcaaggg   262680
aatatgactt ggctttatta attctagaag agcccattgg tgcaaaatta gggactttgg   262740
gtcttcctac tagtcaaaaa aatttgacag gaataactgt gactatcaca ggctatccat   262800
catataattt taaaattcat caaatgtata cagataaaaa acaagtttta agtgatgatg   262860
gcatgttctt ggattaccaa gttgatactt tagaggggtc tagtggatct acagtttatg   262920
atgctagtca ccgtgtagta ggagtgcata ctttaggaga tggagctaat caaattaaca   262980
gtgcagttaa attaaatgaa cgaaatttgc catttattta ttcggttctt aaaggttact   263040
ctcttgaagg atggaagaaa ataaatggta gttggtacca ttatagacaa catgataaac   263100
aaacgggttg gcaggagata aatgatactt ggtattattt agacagttcc ggtaagatgc   263160
ttacagattg gcaaaaagta aatggaaaat ggtattatct caattcaaat ggagcaatgg   263220
ttacaggtag ccaaactatc gatggtaaag tttataactt cgcttcatct ggtgagtgga   263280
tttaatgttg gaggatatat aaaatgaagc ttttgaaaaa aatgatgcaa atcgcactag   263340
ccacattttt cttcggtttg ttagcgacaa atacagtatt tgcagatgat tctgaaggat   263400
ggcagtttgt ccaagaaaat ggtagaacct actacaaaaa gggggatcta aaagaaacct   263460
actggagagt gatagatggg aagtactatt attttgatcc tttatccgga gagatggttg   263520
tcggctggca atatatacct gctccacaca agggggttac gattggtcct tctccaagaa   263580
tagagattgc tcttagacca gattggtttt attttggtca agatggtgta ttacaagaat   263640
ttgttggcaa gcaagtttta gaagcaaaaa ctgctacgaa taccaacaaa catcatgggg   263700
aagaatatga tagccaagca gagaaacgag tctattattt tgaagatcag cgtagttatc   263760
atactttaaa aactggttgg atttatgaag agggtcattg gtattattta cagaaggatg   263820
gtggctttga ttcgcgcatc aacagattga cggttggaga gctagcacgt ggttgggtta   263880
aggattaccc tcttacgtat gatgaagaga agctaaaagc agctccatgg tactatctaa   263940
atccagcaac tggcattatg caaacaggtt ggcaatatct aggtaataga tggtactacc   264000
tccattcgtc aggagctatg gcaactggct ggtataagga aggctcaact tggtactatc   264060
tagatgctga aaatggtgat atgagaactg gctggcaaaa ccttgggaac aaatggtact   264120
atctccgttc atcaggagct atggcaactg gttggtatca ggaaagttcg acttggtact   264180
atctaaatgc aagtaatgga gatatgaaaa caggctggtt ccaagtcaat ggtaactggt   264240
actatgccta tgattcaggt gctttagctg ttaataccac agtaggtggt tactacttaa   264300
actataatgg tgaatgggtt aagtaatgaa ggctaattgt aaactgtgat ggatacttaa   264360
ctttgtataa taggtggata aaagtcttca caatcaaaaa acgcatagta tcaaggtttt   264420
tctgtactgc cctcaaacag ttagacaatt aatttatccg aaggatttag ttctgtattg   264480
cacagggcta agtcctttta gttttacctt aattcgttta ttgttgtagt aatcaatata   264540
gtctataatg gcttgttcca attgcttaag cgactgaaac gacttctcat aaccgtaaaa   264600
catttccgat ttcagaatcc caaagaagga ctccatcata ctattgtctg ggctgtttcc   264660
cttacgtgac atggatgctt gaattccctt actctctagg aaccgatgat aagaatcgtg   264720
ttggtattgc cagccttggt cactatggag aatcgtattc tcgtagtgct tctctgtgaa   264780
tgcctgttcc aacattgttt gtacttgttc taagttgggt gaagttgaaa gattataggc   264840
gataatttcg ctattaaagc catctaaaac tggtgataag taaagctttt gagtacttgc   264900
tggaatggca aattctgtca catctgtgta gcacttttcc attgttttag agccttcaaa   264960
ttggccttga atgagattct ctgccttctt gccaacgtct tttatgagaa gaatattttc   265020
gtttctgtcg cgttttagct tgtaaattga gtactttcat caagccttga attcttttat   265080
gatttaccag ataaccacga tttcttagtt ctaaatgaac ccggcgataa gtataatttc   265140
ccttgtgttc gataaaaatg gattgaattt cagctttaag ctcttagtcc ttatctggtt   265200
tatctagctg tttcaagtga tagtagtagg tcgaacgagc tagtttaatg acttttagaa   265260
gaagagctaa cgaaaattca gtcattaatt cttgaacaat ttctgtcttt cttctttctc   265320
ctccttcaat cggagttctc ttaacttttt taggatggca ttctccgctc tcaggtactc   265380
attttctgct tgaagacgtt ctaattctgt cctctcttca ggtctcgttt ttggcttacg   265440
tcccatttta ggtactctcc ctcttgtttt ctcaacaata gtatacccgt ttttcctgta   265500
ttgtgctagc cagttaagaa gtatcgtacg acttgggaga ccgtattcaa gagaaactct   265560
atctttagtc cagccttcat gtcagacttt attactcatt tcttgtttta aatcaggaga   265620
atagtaacga ttttttcctt ttttgacgaa ctctattccg taacgatcaa tcaatttaat   265680
catgtaccta atattagaat tgcttatccc aaatttattt gaaagcttct ctaagctata   265740
tccttgtttt ctaagttcat agatctgaac tttatcatca taagttagtt tcataataaa   265800
aacaccccaa aagttagatt ttttctgtct aacttttggg gtgtagttca tgtacacctg   265860
atatgatgcg ttttataatt tttaagcctt tttgcccagc ctcgtcaaaa gtaatgtttt   265920
gacacaaaat ctgtgacaaa actttagttt taaaggtttt taactttgta tatactagtt   265980
ttaagaaaag gaggatgatc taatggaaga aaaagtatca ttgaaagtca gggttcaaaa   266040
actagggaca tcgctttcaa atatggttat gcccaatatt ggagcattta ttgcttgggg   266100
agtattgact gccctcttta tcgctgatgg ctatctgcca aatgaacagt tagctactgt   266160
tgttggtcct atgttaacgt atttattgcc aatcctgatt ggttacacag gtggatatat   266220
gatccatggc caacgtggtg ccgttgtagg agctattgct actgttggtg caatcacagg   266280
ttctagtgtt cctatgttta tcggagctat ggtaatgggc ccactgggag gatggactat   266340
caagaaattt gatgagaagt tccaggaaaa aattcgtccc ggatttgaaa tgttagttaa   266400
taacttctca gctggtctcg ttggttttgc attattgctt ttggctttct acgcaatcgg   266460
tccagtcgta tcgactctta ctggagctgt tgggaatggt gttgaggcta ttgtcaatgc   266520
tcgcctcctt cctatggcta atattatcat cgaaccggct aaagtccttt tcctcaataa   266580
tgccctcaat catggcattt ttactcctct gggagtagaa caggtagctc aagctggtaa   266640
gtcaattctc ttcctattgg aagctaatcc tggaccaggt ctgggaattc tattagctta   266700
tgctgtattc ggtaaaggtt ctgctaaatc ttcttcttgg ggggcaatgg ttattcattt   266760
cttcggaggg attcatgaaa tttactttcc ttatgttatg atgaagccta ctctattttt   266820
agctgctatg gcaggaggta tctctggaac ttttactttt caactcttag acgctggtct   266880
taaatctcca gcttcaccag gttctattat tgcgattata gctacggcgc caaaaggtgt   266940
ttggccccat ctaaatgttc ttttaggtgt tttagtggca gcagttgttt ctttccttgt   267000
agcagccctt attcttcatg cagacaagtc aactgaggat tcgctcgaag ctgctcaggc   267060
ggctacccaa gcagctaagg ctcagtctaa aggtcagtta gtatcaactt ctgttgatgc   267120
agttgtttcg acagactcag tggaaaaaat cattttcgcc tgcgatgctg gtatgggaag   267180
ctctgctatg ggagctagta ttcttcgaga taaggttaaa aaagcaggtc tagagattcc   267240
agtatctaat caggcaatct caaatttgct tgatacacca aaaacattaa ttgttactca   267300
ggaagaactg acaccaagag ctaaagacaa gagtccaagt gctattcatg tttctgttga   267360
taatttctta gcgtcctctc gttatgatga aattgtagct tcattaacag gagcttctcc   267420
aatagcagaa attgaaggag atataccaac ttcagcacca gtagatagtc aggaaagtga   267480
ccttaaccat attgatgctg tagtagttgc ttatggtaaa gcacagggaa ctgcaactat   267540
gggctgtgaa acgattcggg ctatttttag aaacaagaat attcgtattc cagtttctac   267600
tgccaaaatt tcagaattag gtgaatttaa ttctaaaaac ataatgattg taacaactat   267660
ttctttacag gcagaagtgc agcaagcagc accgaattct caatttctta ttgtggatag   267720
tttagtaaca acaccagaat atgacaaaat ggctgctaga atgtacaaat agaactagag   267780
gtttctaaat tacgaatgct attaaccaaa cgagaagaac aattattgaa ggctttccta   267840
catgtaggga agctttcaat gcaagatatg actgaaatct tacaggtttc atctagaaca   267900
atttatcgaa ctttatcaga tttgacagat agcatggagc aatatggaat cgaaataacg   267960
aagcatggga aatactatat tttgactgga gagttggatg atttgccgac agaacttgaa   268020
gtgttagttg agtatagtcc ccaagaaaga caagagttga ttacctatcg ccttctgact   268080
gagagtggtt ttgtcaccaa tgaagcattg caagagtgca cgaaagtcag taatgtaact   268140
attattcagg atatttcaga tattgataag cgtcttttag actttgatct gaaaattgaa   268200
cgacaaaaag gttatcggat ttctggtgat tcagttggta agagaagatt tttggctatt   268260
ttactgacaa actgtatctc agtagcagat ttttcaaccg gtaattttgg gagctttgat   268320
attttagaag cagatagaac tgggctggcc agtcagattg ttaataagca actgtcaggt   268380
tttccagata tggatgctag gatgaagatg ttttttgcga tcttgttatc tcttataggt   268440
caggagcaaa acattgaaaa ttcacctaat actagtaagc aggctttgga aatttctcaa   268500
aaaatttttc aagcttactc taagcagact gcacaatttt atagtattca ggaaattatc   268560
tattttgcga gcatcttgga tgaattaatc attaaacgtc aggacaatcc gctctttacg   268620
gagaaatttg atggtgaatt tttctacaat atttcaaatc tgattgatac ggtttccatg   268680
tataccaaga ttgacttttt taaggacaag gttttattca attttctttt ccatcatatt   268740
cggctcagtt taggcgtccc tatccttttt cagggtgaaa atttgccaga atctatccag   268800
attttagttg aaaggaataa atttctttat acagtcatca gtcttttagt gaatgatatt   268860
tttccgaaat atcttcatac agagtatgag tatggcatga ttgccctaca ttttatctct   268920
agcttaggcc gtagtccaga gatttatcca gtccgtgttt tgcttttaac ggatgaacgt   268980
cgggtcacta gagatttatt agtcagtaaa attaagagtg ttgctccttt tgtagagttg   269040
atagatattc aatctctagt agattaccac agtattgatc tcagtcagta tgattatatt   269100
ttatctacca agccgctgac taatcaggaa atcgatgtaa tttctagttt tccaaccgtc   269160
aaagaattgc ttgaattaca ggaacgactt cagtatgtac aggcacatcg tacaattgtc   269220
gcgcgtgatg ctatcgctcc agagaaaagt tatgacttgc aagattattt aatatctagt   269280
agtcagcttt tgagtcaatt cgagttggtt caattggaga ataatcaatc atttgagcac   269340
acggtagaac aaatcatcca atatcagaag aatgtgagtg acagagctta cctaacaaga   269400
aaattgttat ctcacttcca gaatagtcct atggctattc ctaatactgg tctggtgctt   269460
ttacatagtc agtctagcaa agtaacaaca aatagtttta ctatgtttga actcaaacta   269520
cctatctccg cattgtcaat gaaacgagag gaagaagagg tcaaaaggtg tctgctaatg   269580
ctaatgtcta aagaagctag cgaggaagct agagatttaa tgacagctat tagtcagtcg   269640
attattgaaa atcatcttta tacagagatt tacaagacgg gaaatcaatc cattatttat   269700
cagatgctaa atactatttt taacgaaaaa attaagaaat tggagaacta atatgaaact   269760
tgaaaaacat ttgattaagc ttaataaaca attttctaac aaggaggaag ctatttgtta   269820
ttgtgggcaa gttctttatg agggtggata tgttaatgaa gactatattg aagccatgat   269880
tgagcgagat aaagagctat ctgtttacat gggtaacttt atcgccatac cgcatggaac   269940
agatgcagca aaaaatgatg tcctcaagtc tggtattaca gtcgttcaag tccctagagg   270000
ggttgatttt gggaatgtat ctaaccctca agtggcaacg gttctttttg gtattgctgg   270060
tattggtaat gaacacttag aaattattca gaaaatttct atcttctgtg cagatgtaga   270120
taatgttctt aaactagcag atgctcagtc aaaagaggaa gtattgcgct tatttgatgc   270180
tgttgaataa ttgaatttag tcatttgtca tctagtatat atgtccctca aataggaaaa   270240
ggagaaattg aatgaaacat tctgttcatt ttggtgccgg taatatcggt cgtggtttta   270300
taggtgaaat tctatttaaa aatggtttcc atattgattt tgtggatgtc aataatcaga   270360
taattcatgc tctgaatgaa aagggcaagt atgaaattga aattgcacag aaaggacagt   270420
ctcgtataga agtaactaat gtggctggca ttaatagcaa agaacatcct gagcaagtca   270480
ttgaagcgat tcaaaagacg gatattatta ctactgcaat cggacctaat atactccctt   270540
ttatcgccga acttctagcc aaaggaatcg aagctcgccg agttgcagga aatacacagg   270600
cattggatgt tatggcctgt gaaaatatga ttggcgggtc tcaatttctt tatcaagaag   270660
tcaagaaata tttaagtccg gaaggtttga catttgctga taactacata ggttttccaa   270720
atgctgcagt agacaggatt gttccagcac aaagtcacga agattccctt tttgttgtgg   270780
tcgagccctt taatgaatgg gtcgtggaaa ccaagcgtct taaaaatcca gatttacgtc   270840
taaaagatgt gcattatgaa gaagatttag aaccctttat tgagcgaaaa cttttttcag   270900
tcaattctgg acatgcaact tcagcttaca ttggtgcgca ttatggtgcc aagacaattt   270960
tggaagctct tcaaaatcct aatattaaat ctcggattga atctgtatta gctgaaattc   271020
ggagtctctt gattgccaaa tggaactttg ataaaaaaga attggagaat tatcacaaag   271080
tcattataga acgacttgaa aaccctttca tagtggacga ggttagtcgc gtagctcgta   271140
ctccaatccg aaaattaggc tataatgaac gattcatccg gccgatacgt gaattgaaag   271200
aactcagttt gtcatataaa aacctactta aaacagttgg ctatgtcttt gactatcgcg   271260
atgtaaatga tgaagaaagt attcgattag gtgaattgtt ggctaaacaa tcagtcaaag   271320
atgttgttat acaagttaca ggtttagacg accaagaatt gattgagcaa attgtagagt   271380
atatttaatc tttttcgaaa atctcttcaa atcaggttag catcgctttg tcttaggcat   271440
atgttgttct atctacaacc tcaaagcagt gctttgagct gactccgtca gtcttatctg   271500
caatctcaaa acactgtttg agttatctgc ggtaatcttt ctagcttgtc tttgattttt   271560
gttgttattt ataaggtaaa agaagctgga caaaaagtct tcaaaatcgg gaaaaggcag   271620
cctatcgggt gttcaaaaat cttgatagga tgtcctttat tatggaaagc cttattggat   271680
tttctcctca gattgagttt ttgatcagct ttatgagata ggtcttgcta gagatgtagc   271740
ccatcatgtt atttttatgg acagtgggaa aattgttgaa aaaaataatg cccatcaatt   271800
ctttagtcgt ccaagagaag aacgaaccaa gcaattttgg aacgaattct ttcgaatgcg   271860
atctatatag taaaatgaaa caagaacagg acaaatcgat caggacagtc aaatcgattt   271920
ctaaaaatgt tttagaagta gaggtgtact attctagttt caatctacta tataactgaa   271980
aaattagata aattagtttt ggaaaatgac taaccaaaag atatccaaag tagtctaaaa   272040
ttgtctatac tttatgagtg ttttagttag gaaaaaggct tgttgtctat aattgtctgc   272100
attagtctag attttattta tagaaaatgt tataatagac tgtatttaaa aaattttaag   272160
gagaaatgac agaatgtctg tatcatttga aaacaaagaa acaaaccgtg gtgtcttgac   272220
tttcactatc tctcaagacc aaatcaaacc agaattggac cgtgtcttca agtcagtgaa   272280
gaaatctctt aatgttccag gtttccgtaa aggtcacctt ccacgcccta tcttcgacca   272340
aaaatttggt gaagaagctc tttatcaaga tgcaatgaac gcacttttgc caaacgctta   272400
tgaagcagct gtaaaagaag ctggtcttga agtggttgcc caaccaaaaa ttgacgtaac   272460
ttcaatggaa aaaggtcaag actgggttat cactgctgaa gtcgttacaa aacctgaagt   272520
aaaattgggt gactacaaaa accttgaagt atcagttgat gtagaaaaag aagtaactga   272580
cgctgatgtc gaagagcgta tcgaacgcga acgcaacaac ctggctgaat tggttatcaa   272640
ggaagctgct gctgaaaacg gcgacactgt tgtgatcgac ttcgttggtt ctatcgacgg   272700
tgttgaattt gacggtggaa aaggtgaaaa cttctcactt ggacttggtt caggtcaatt   272760
catccctggt ttcgaagacc aattggtagg tcactcagct ggcgaaaccg ttgatgttat   272820
cgtaacattc ccagaagact accaagcaga agaccttgca ggtaaagaag ctaaattcgt   272880
gacaactatc cacgaagtaa aagctaaaga agttccggct cttgacgatg aacttgcaaa   272940
agacattgat gaagaagttg aaacacttgc tgacttgaaa gaaaaataca gcaaagaatt   273000
ggctgctgct aaagaagaag cttacaaaga tgcagttgaa ggtgcagcaa ttgatacagc   273060
tgtagaaaat gctgaaatcg tagaacttcc agaagaaatg atccatgaag aagttcaccg   273120
ttcagtaaat gaattccttg ggaatttgca acgtcaaggg atcaaccctg acatgtactt   273180
ccaaatcact ggaactactc aagaagacct tcacaaccaa taccaagcag aagctgagtc   273240
acgtactaag actaaccttg ttatcgaagc agttgccaaa gctgaaggat ttgatgcttc   273300
agaagaagaa atccaaaaag aagttgagca attggcagca gactacaaca tggaagttgc   273360
acaagttcaa aacttgcttt cagctgacat gttgaaacat gatatcacta tcaaaaaagc   273420
tgttgaattg atcacaagca cagcaacagt aaaataatct taataaacag aaaacccacc   273480
tgaattggtg ggttttctga tgcactattt tccaaaaatc tctttgaggt ctgtgtctgt   273540
aatcccaatc atggctggga tgcggtccca gttttcttcg gttaggatgt aggattgttc   273600
agaggcactt gatgtgactg tttcagagac agcttgttgc ttttcttcaa cattctccag   273660
tagatcactg aagcgttcaa tcagataggt ttttcgggca gttccgatgt gttgggtagc   273720
atagtcgaag gcttgtaatt cgcctagtaa gatgagtttg cttttggcac gtgtaatggc   273780
tgtgtagatg agatttcgct ccagcatacg tcggctagca ctagtaatcg gtaggatgac   273840
aactgggaac tcacttccct gagacttatg aatactcatg gcataggcca agcgaatctt   273900
gtaccattcg ttacgggggt aagagacttc attaccatca aaatcaatga caatctcgtc   273960
ttgtttcgat tcggtgtatt taccaggaat caggtctgtg atagctccta aatccccatt   274020
aaagacattg atttcagcat cgttaaccaa atgaatgacc ctgtctctct tacgatagtg   274080
acactgagga gcttcaaaac tgagttgatc tttttgtggg ggattgagca ggtcttgcat   274140
gagctgattg atagcatcaa tccctgccgt ccctcggtac ataggagcca gaacttggat   274200
atcacgggcg ggaataccat ttctgagggc ggcacctaag attttttcaa tggtggcagg   274260
aatatggcca ctagcaattt caaagtagga acggtcagct tttttttggg tgaaatcagc   274320
tggcaagatg ccctgtcgaa tctgactagc tagggtgacg atggttgatt ctttgctttg   274380
tcgataaatt ttttccaagc gagtctgagg aatcaaagga atatgaagta gatccgctag   274440
aacctgtcca ggactgacag aaggtagctg atcactgtca cctacgatga ggatcttact   274500
gttagaagag atattggaga agagttgatt ggccagccaa gtatctacca tagagaattc   274560
atccacgatg ataaagtcag catctaggta atcttccaga tgactggtat catcgtcacc   274620
tgtcattccc aagtggcgat gtatggtcgc gctaggcaaa cctgtcaatt cattcatgcg   274680
acgagcagct cgaccagttg gagcagcaag aagaatgggc agattgcttt tcttcctgaa   274740
gtcaagtcct tctaaaaggg cataaacagc aatgattcca ttgataacag ttgtcttacc   274800
agtaccaggc ccacctgtca ggataaagac cttattctgg atagcatcac agatagcctg   274860
tttttgaatg ttatcatact caattcccag ttcttgctcg acagtagtga tatgtttttg   274920
aatggtttct aaatcatgac tcttctgttt tcctttttca aggatacgaa ccaagtgact   274980
gcggatgcct tcctcagcga aaaagaggct gttgtcaaag atcttggtat caatctgctg   275040
aaccttgtct tcttcgatca ggtaggagag ctcttgggca acttggctgg ggtctagttc   275100
cacgggacgg gaagactcaa ggagagtaag ggtttgttcc agcaaatccc gtgcttcaac   275160
ataggtgtcc cctgtttcca tacaggcctg aaaaagactg tgaactagac cggcgcggaa   275220
gcgttcagga gcctgacttt cgatgcctag ttcctcagct agttggtcag caatggtaaa   275280
gcccaaaccc ttgatatcct caaccagctg gtagggataa ttttcaacca catcaagggt   275340
ttcttccttg taaaagtctt gaatctgaaa ggctagtttg ttgggaatgc cgtagttggc   275400
tagtttggcc aaaatcatct ccgttccgta gttgagacgg agagtggaga cgaaagcctc   275460
gcgatttttg gcagagagtc ctgcgatgcc ttctaacttt tctgggtgtt gcaaaatttc   275520
gtcaatggta ttttcgccat aggtatccac gattttctga gctgtcttga gaccaatccc   275580
cttgaaatgg ctacttgaaa agtacttgac caagccctta ctagttggtt ttgcgcgatc   275640
ataacgactg atttgcagtt gttctccata cttggagtgc tggacaattt gcccccaaaa   275700
agtatagtct tcgccctcaa ttacatcagc catggttcct gtgacaatga tttcaaaatc   275760
atcaaaatcc tctgcgtccg tatcgtcgat ttctaggagg aggatgcgat aaaaattgct   275820
gggattttca aaaataatcc gttcaatagt tcctgaaaaa taaacttcca taaaattcct   275880
ttgcatgaat aggtgagagt tgggattgtt tttattttat actcttcgaa aatatcttca   275940
aaccacgtca gcttccatct gcaacctcaa aacagtattt tgagctgact tcgtcagttc   276000
tatccacaac ctcaaaacac tgttttaagc agcctacggc tagcttccta gtttgttctt   276060
tgattttcat tgagtatttg taaataaaca atcacttctc acgatagaag aagaggctga   276120
gattggtgat tctctgcctc ttaggtttct taaaatgttc cgatacgggt gattggccat   276180
aagcggaatt tagcttcccc tgtgatatct tttgctttga aggtacctac gtggcggctg   276240
tcgctcgaaa ccaagcggtc atctccgagg agaaggtatt ctccttctgg aacagtaaag   276300
ctaaagttgg tgttgtagtt gacatcaact gtgaaggctt gagctttttg agcgatactt   276360
ctaaagaaag ttcctttatt tccttcaaag cccttgcctg agtaagtgct ttggagtttg   276420
tcatccttga agcgtttgat atagtctgct agataaggct cgtccgtttc tttgtcattg   276480
atgtagagtt tatcattttc gtaacgaatg gtgtcgccag gcattccaat cacgcgcttg   276540
acgatgtcct tattgccatc ttcctcatgg gccaccacga tatcaaaacg gtcaatagga   276600
aggtgtttta caacgaagag aatttcgcca tccgctaggg tcggatccat ggaatgtcct   276660
tctacgcgaa cattgctcca aaaaaagata cgacttaaag ctagtaatga cagaattagg   276720
aggaacaatc cccactcttt taagaaattt ttaaatgaat tcataactta cctttctaag   276780
cgttttttcg ctttttcagt gtttttaaag tgcaatttgg cgcagaagct gagtccctgc   276840
ataccatagg cttgcaaaat ctggctagcc accttgtcag aagccgttcc agctccactt   276900
gggagctgat aacccagttc tcgtcccaaa ttttcaagat tttccagaaa gagatcacgc   276960
gcaatgacag aagaaactgc gacagacaag tatttgccct cagccttttc ttctaagctg   277020
ataggattgc tgaaacgatt ggcctcttgt gccaagtact tgtcataatt tttagcactg   277080
gtaaaggcat caatcacaat tttctcaggc tgaacacctt tttgaaggag gagatagata   277140
gcctgattat ggagggcaac cttaaccgaa acagcgttgt agcggtctcc gatgacctcg   277200
ttgtacttgc tgggtgagag aaggagtgcc tggtgctgaa ttttttcctt gagaatagga   277260
gtaatctgac ggatcttttg gtcggtcaga gtcttagaat cccccacacc gagttttcgt   277320
aaaaagtcgt gctggtcagg tgtgacaaag gcagccacaa ctgcaagccc accaaagtag   277380
gaaccatttc ccacctcatc tgtcccaatt aaaggaagat tttgtccgct ggtttgctct   277440
acagcttgat agccaaagaa actggcgtat ttttcagccc cttcaccctg aagcaagatt   277500
tttccagaag tatagataga aaccgttgct tgaggtagtt tcaaaaagta gcggatatag   277560
ggattcttgc taggagccag actggtttga tagtgttcaa gaaaagcctg aatatccttt   277620
tcgcttggtg tgagtgtgat acttgccata gtttctattg taccacaaaa gcagtaaaat   277680
ttgtaaaaac tgacaaaatt agcgaatttt ggtataatat cgtgaggtga attttatggc   277740
aaatctaaat cgattcaaat ttacattcgg gaaaaaatcg ttaaccttga caagcgaaca   277800
tgacaacctt tttatggagg aaatcgctaa ggttgcgaca gaaaaatacc aagcaattaa   277860
agaacaaatg cctagcgcag atgatgaaac aatcgctctt ttgttggcag tcaactgttt   277920
atcaactcag ctcagccgtg agattgaatt tgacgataag gagcaagagc tagaagaact   277980
ccgtcacaag cttgtgactt gtaagcaaga acagagcaag attgaggatt ccttatgatt   278040
tcattccttc ttctattggt cttggtttgg ggattttata tcggctatcg gagaggcctg   278100
ctcttacagg tttattacct gatttcagcc atggcatcgg cttttatggc tggccagttt   278160
tataaggggc ttggagagca attccattta ttgctccctt atgcaaattc gcaggaaggt   278220
caggggactt tctttttccc atcggatcaa ctctttcagc tggataaggt cttttatgca   278280
ggtatcggct acttgcttgt atttgggatt gtctatagca ttggtcgttt acttggtctt   278340
ctcttacact tgattcctag caaaaaactg ggtggtaagt tgttccaagt ttcagcaggt   278400
atcttgtcca tgttggtgac cttatttgtc ttgcaaatgg ccttgacaat cttggcgacc   278460
atccccatgg cagttataca aaatcctctt gaaaagagta tcgtcgcaaa acacatcatc   278520
cagagcatac cggtaacaac cagttggctc aaacaaatct gggtgacaaa tttaatcgga   278580
taaaaagggc aggagttttc ctagcccttt gtttacagat ttgactcgaa tctatcagaa   278640
tgtaaaaagc taccacacct agacattcaa agacaaggaa ataaagatga ataagaaaat   278700
attagaaaca ttagagttcg ataaggtcaa ggccttgttt gagcctcatt tgttgaccga   278760
gcagggcttg gagcaattga gacaactggc tccgactgcc aaagcagata aaatcaaaca   278820
ggcttttgct gagatgaagg aaatgcaggc tcttttcgtc gagcaaccgc attttactat   278880
tctctcaact aaggaaattg caggagtctg caagaggttg gagatgggag cggatctcaa   278940
tatcgaggag ttcctactct tgaaacgcgt gcttcttgcc agccgagaac ttcaaaattt   279000
ttacaccaat ctggaaaatg tcagcttgga agaattagcc ctttggtttg agaaattaca   279060
tgattttccg caattacaag gaaatcttca ggcctttaat gatgcgggtt tcattgaaaa   279120
ttttgccagt gaagaattgg cgcgaatccg tcgaaaaata catgatagcg agagtcaggt   279180
acgcgatgtt ttacaagact tgctcaagca aaaagcgcag ctgttgacgg aaggaattgt   279240
tgctagcaga aatggccgtc aggttttacc agtcaaaaac acctaccgca ataagattgc   279300
aggtgtcgtt catgatattt ctgctagtgg aaacaccgtc tatatcgaac cccgtgaggt   279360
agtcaaactg agcgaagaaa ttgctagtct gcgagcagat gagcgctatg aaatgcttcg   279420
cattctccaa gaaatttctg agcgtgtccg ccctcatgcg gctgagattg ctaatgacgc   279480
ttggattatc ggtcatctgg acttgattcg tgccaaggtt cgatttatcc aagaaagaca   279540
agcagtcgtg cctcagctgt cagaaaatca agagattcaa ctgctccatg tctgccatcc   279600
tttggtcaaa aatgccgtcg caaatgatgt ctattttggt caagatttaa cagctattgt   279660
cattacaggt cccaatacag gtgggaagac catcatgctc aaaactctgg gcttgacaca   279720
ggtcatggcc cagtcaggat tgccgatttt agcagacaag ggaagtcgtg ttggtatttt   279780
tgaagaaatc tttgctgata ttggagatga gcagtctatt gagcagagct tgtctacctt   279840
ctctagtcat atgaccaata tcgtggatat tcttggcaag gtcaaccaac attcactctt   279900
acttttggat gagttggggg ctggtactga tccccaagag ggagcagccc ttgccatggc   279960
tattctggag gaccttcgcc tgcgtcaaat caagaccatg gcgacgaccc actatccaga   280020
actcaaggcc tacggtattg agacagcctt tgtgcaaaat gccagtatgg agtttgatac   280080
tgcaactctt cgcccgacct atcgctttat gcagggtgtt cctggccgaa gtaatgcctt   280140
tgaaattgcc aaacgtctag gcctatctga agttatcgta ggagatgcca gtcagcagat   280200
cgatcaggac aatgacgtca atcgtatcat tgagcaatta gaagagcaga cgctggaaag   280260
ccgcaaacgt ttggacaata tccgtgaggt ggagcaagaa aatctcaaga tgaaccgtgc   280320
gctaaaaaaa ctctacaacg agcttaatcg tgaaaaggaa accgagctta acaaggcgcg   280380
tgaacaggct gctgagattg tggatatggc cctaagtgaa agtgaccaga ttctcaaaaa   280440
tctccacagt aaatcccaac tcaagcccca cgaaatcatt gaagccaagg ccaagttgaa   280500
aaaattggct cctgaaaaag tggacttgtc taaaaataag gtccttcaaa aggccaagaa   280560
aaaacgagct ccaaaggtgg gagatgatat cgtggttctc agttatggtc agcgtggtac   280620
cttgaccagt caactcaagg acggtcgctg ggaagcccaa gttggcttga ttaagatgac   280680
cttggaagag aaagagtttg atcttgttca agcccagcaa gaaaaaccag tcaagaagaa   280740
acaggtcaat gttgtgaaac gaacttctgg gcgaggacct caagctagac tggatcttcg   280800
aggcaagcgc tatgaagaag ccatgaatga gctagatacc ttcatcgacc aagccttgct   280860
taacaatatg gctcaagttg atatcatcca tggtatcgga acaggagtca tccgtgaagg   280920
agttaccaaa tacttgcaaa gaaacaaaca tgtcaagagt ttcggctatg ccccacaaaa   280980
tgctggaggc agtggtgcga ctattgtcac ttttaaagga tagcagtatt ctggacttta   281040
taaagtaaaa actgttgaac taatttttac taataaacac attgacaaaa gccaacattt   281100
tttgtaaaat tagaatcaat taaataccaa caccgaatga agtttaatag aagtggggaa   281160
tcgtttgatt ttccatgact gtaaatggac ggaactctgg agagaccgta aaggcaccga   281220
aggggcaagg caggcaactg ctcaaactct caggtaaaag gacagagcta ggatagaccg   281280
ctttttagca tttatctaag cattccagag tacatgtatc ttgcatgtgc tctttctttt   281340
ggggttgaaa cgataggaga aggaaatgtt agaattgctt aaatcaatcg atgcttttgc   281400
ttggggaccg cccctcttga ttttattggt cggaacaggg atttacctaa ctattcggct   281460
aggactcttg caggttttgc gtctacccaa ggcctttcag cttattttta tccaggataa   281520
gggacatggt gatgtatcca gttttgcagc tctgtgtaca gccttggcat caactgttgg   281580
aacaggaaat atcataggag ttgcgacggc tatcaaggtt ggtggaccag gagctctatt   281640
ttggatgtgg atggcggctt tctttggaat ggctaccaag tatgcggaag gactcttggc   281700
catcaaatac cgcaccaagg acgaccatgg tgcagtagcg ggaggtccca tgcattatat   281760
ccttctaggg atgggagaaa agtggcgacc acttgctgtt ttgtttgcag tagcaggagt   281820
attggttgct ctcttgggaa tcggaacctt cacccaagtc aactcgattg cagaatctat   281880
ccaaaataca acgacgattt cgccagccat cacagctctc gtcttgtctg tctttgtagc   281940
gattgcagtc tttggtggac tcaagtctat ttctaaggtt tcaactactg ttgttccttt   282000
tatggccatc atttatatct taggaactct tacagttatt ttctttaata tcggaaaaat   282060
ccctggcaca atcgctttag tctttacctc agcttttagt ccccttgctg cggtaggtgg   282120
atttgctggt gctagcgttc ggatggctat tcaaaatggt gtggcgcgtg gtgtgttctc   282180
aaacgaatct ggtctgggtt ctgctcctat tgcagctgca gctgccaaga caaatgaacc   282240
agtagagcaa ggtttgattt ccatgacagg aacctttatt gataccctca tcatttgtac   282300
tctaactggt ttgaccatct tggtaactgg agtttggagc ggtgacttga atggggttgc   282360
cttgactcag tcagctttct caacaaactt ttcacacttt gggcctgctc tcttgaccat   282420
cttccttgta ctttttgcct ttacaacgat tctaggttgg aactattacg gagaacgctg   282480
ttttgagttc ctctttgggg ttcgctttat ctggctctac cgtgtggttt ttgtgctcat   282540
ggtcttgtta ggaggattta tcgagttgga tatggtctgg attatcgcag atatcgttaa   282600
cgccttgatg gctctgccaa acttgattgc cctcttggtc ttgtcgccag tcgttattgc   282660
tgaaactaaa aagtattttg acaaataatg gaatcacaca gctcgtgtga tttttttgcc   282720
tataaataat ttttatcagc ctgatatata atatatatta tacaagtgat tggaagtgtg   282780
ataaactaat ataacaacga aaatcttatg agagaataaa gctttatctt agataaactt   282840
aggaatcagg attttataag attttccaat aatattagtg tcaataataa gaaaagaggt   282900
atcttatgac aacatttact atccatacag tagagtcagc accagcagaa gtgaaagaaa   282960
ttcttgaaac agtagaaaaa gacaacaatg gctatattcc caacctaatc ggtctcttgg   283020
ccaatgcccc gactgtttta gaagcctacc aaattgtctc atctatccac cgtcgcaaca   283080
gcctgacacc cgttgagcgt gaagtggtgc aaatcacggc agccgtgacc aatggttgtg   283140
ccttctgtgt cgcaggtcac acagcctttt ccatcaaaca aatccagatg aatgatgact   283200
tgattcaagc tcttcgcaat cgtactccaa ttgaaacaga tcctaaattg gataccctag   283260
ctaagtttac cttggcagtt atcaatacca agggtcgtgt aggagatgaa gccttgtctg   283320
agtttttaga agctggctac actcaacaaa atgccttgga tgtggttttt ggtgtcagcc   283380
tagcaatcct ctgtaactat gccaacaact tagctaatac accaattaat ccagaattgc   283440
aaccttatgc ctaattcata tctgagtaaa atgaagtctg aaataagcgg acttcgtttt   283500
tttaaatcct catttaagcg cttttatgtt atactgaaac taacatgatt attggaggtt   283560
aggatgaaaa aactcccctt agtattttca ggttgtttgc taggtttggc aggagctgga   283620
aatcttattt tagatacgtt gccggttcta tcccatcttt ttagtctgat tggtttggtt   283680
ttatggattt actttctaat tctgcatctc tttaattgga aagaaaccaa gcaagaattg   283740
accaagcccc ctcttttgtc aggaatggca acctttccta tggctgggat gattttatcg   283800
acctatgtct ttcgcgtatt ctcttatctt cctttggtag cacaagggat ttggtggttt   283860
tcatttctct tggatttgac cttgattgct ggttttacca tcaagtttgc ttgtccaggg   283920
cggagggttc atgccactcc aagctggacg gttctctatg tggggatagc agtggctgcc   283980
ttgacctatc ctctggtagg tattatcgaa attgcctatg cgaccttgag ttttggtttt   284040
ctcttgacct tctatctcta tccccttatt tatagcgatt taaagaaaca tccactccca   284100
ctagccttgc ttggacaaga aggaatctac tgtgctcctt tctctctact cttggcttct   284160
ctagttcgag taggaggaac cagcctgccg acttgggtct tgattgtcat gattttggct   284220
tctcaatcct tctttttctt tgttttaact cgtctgccca acattttaaa acaaggtttt   284280
caaccagcct tctcagccct caccttccca accattatca cagcgacctc gctcaagatg   284340
gctcagggaa ttttgaaact tccatttctg gattacctgg tattggctga aaccattata   284400
tgcctaacta ttttattctt tgtactaggt gcttatctga tttggttacg aaaaaaggtc   284460
tagctagaaa tagctaaacc ttatttttta tggtttgatg acttcagctc cacccatgta   284520
tggacgaagt gcttctggga tggtcacaga accatcttca ttttggtaat tttcaagaat   284580
tgcagccact gtacgtccaa ctgcaagtcc agaaccgttc aaggtatgaa ggagtttcac   284640
cttgccatct gcttcatcac ggtaacggat ttgggcacga cgggcttgga aatcttctgt   284700
gtttgaacag cttgagattt cacggtaatt gttttgtgct ggaatccaca cttccaagtc   284760
gtaagtcttc gcagctgaga agcccatatc tccagtagag agagcaacga cacggtatgg   284820
aaggttgagt ttttgaagaa tgttttcagc gttggctgtc attttttcca attcttcgta   284880
agattcttct ggtttggcaa atttgaccat ttcaaccttg tggaattggt gcaaacggat   284940
caagccacgc gtatcacgac cggcagaacc agcctcagaa cggaatgacg gactcatggc   285000
agtgaagtag attggaagat ctttgccgtc taagatttca tcacggtagt agtttgtcag   285060
aggaacttca gcagttggaa tcaagacaaa gttggtatcg ctgagttcaa aagtatcttc   285120
cttaaatttt ggatactgac cagtaccaaa catagaatca tggttgacta tgtaaggtgt   285180
gatgacttca gtatagcctt cttttccatg ttcatccaac ataaagttgt agatagcacg   285240
ttccaaacga gcaccgaggc ctttatagaa gaggaagcga gcgcctgtta ccttaccacc   285300
gcgttcccag tcaaggatac caaggtcttc accgagatcc cagtgagctt taggttcgaa   285360
gtcaaactcg cgtggagtac cccaacggcg aacttccaca ttgtcgtctt cgtcagcccc   285420
aacaggaacg ctgtcagctg ggatatttgg aagagtcgtt gtaaattctg tcaatttagc   285480
atcgatttct gccaattcag catccaaggc tttaacctca gcagatagat tttgcatggc   285540
agcaatcttg tcatctgtat tttccttgtt gcgcttagct tgggcaatct cagcagaaac   285600
tgtgttacgt tctgctttga gagtttcaac cttgaccaag atgttacgac gtttagcatc   285660
gatttctttc atttcattca agacagcagc atctacacca cgtgtagcta atttttctgc   285720
gacagcttca aaatctgtac gaatacgttt gatatctaac ataagaactc ctttatgaaa   285780
aaagcaccct gacaaaacgt tggagtggca gggccacggt tccatccaac ttcacaggtg   285840
tgcacttgat tgtgtatgta attgtcacta acggtagaat ttcacctatc cctcctatct   285900
gctcgcagta cccgcagact ttctgaaaga agaagataac ctacttatcc gttgctatga   285960
ttatactaaa gtttctactt ttttgcaaat agatttttaa atttttggct aattgtctga   286020
atcagggtcg gaagtttgac gaccttgtca ttgcctagtt tttcgcgtgc aattttgaga   286080
atggcacctg agtcttttga agcaaagagg aattttcctt tgtctgtaaa gacttcgaag   286140
tggcggctga ttttgcgtcc agtgacattg gctccaatct gattgatatg gctccaagga   286200
atctggataa attgttcgac attgacatct gggtaaaatt ccaaagcctg atctccgaca   286260
aggaatttcc caactttccc agcgatagag aggtaggaag tgcctgtcgt actgaggagt   286320
actgttttgt taagtgattg ggccatgctt agtcttcctt actttctcca aaaaaggcat   286380
tgtagagggc tttaattgct gctttctctt ggtctttatt gacaacaaac ataatagaaa   286440
cttcactaga accttgagac atcatctgga tgttgatttt gttttcagat agagcgcgtg   286500
tcgcagtagc agtcactccg atatggctct tcattttttc accaacaatc ataatgatag   286560
aaaggtcgtg ttcgatttct gcatgatcta ctttagcctt ttgaaccaac tgacgcagga   286620
tttcttcttc cttgatggga gttagttggc gagaacggag aatgatagaa agatcgtcga   286680
tacctgttgg catatgttcc caaccgatgt taagttcttc caggatttgc agaaccttgc   286740
ggccaaatcc aacctcacgg ttcatgaggt atttcgacat gttaatgctg acaaagcctg   286800
agtcaccagc aattcccaca actggaaatt catcattact gtgttttaga acgatacgag   286860
tacctggatg gtcagggttg ttggtattct tgataaccag aggaattttt ccacggtagg   286920
caggaagaag agcctcgtca tgaaggactg agaagcctgc ataggccaac tcgcgcattt   286980
cacggtaggt caactcagga atcgagtgtg gttggtggat aataccaggg tgggctgcaa   287040
agataccatc aacgtccgta aagttttcat agaggtcagc tttgacacca gcagcaatga   287100
tagaacctgt aatatcagaa cctccacgtg agaaagtaca gatttgattt tccttagtga   287160
caccaaagaa accaggaatg acaaggactt cattggtgtt tgtcaattct tcaatcttgt   287220
cataacttga tggaatgatg cgagcgtgac caggttcact tgtgaccaca atcccagctt   287280
ctctagggtg catatagcgt gcatcgatac cattttggtt aaagtaggca gcaatcaatt   287340
tggcattgtt attttcaccg gctgctagga aagtatcgta gagaaattca ttttcttcaa   287400
taggaagagt ggccaaggcg tgaatgcttt tagaaatttt ttctagcaca gctggtttta   287460
gtcccaattc actaaccata gcagcatagc ggtcgataat ccagctttgg ttcttgctaa   287520
tatcgttacc cgcaacatag tcgcggtagt atttaatcag ggcatccgta accttagtat   287580
cttcagcatt gcgtttacca ggcgcagaaa cgactacaaa acgacgctct gaatcgcttt   287640
tgacgatgtt taaaactttt tctaattgac tagcagaggc aagagaacta cctccaaatt   287700
taacaacttt cataagaact cctaaagtaa gtattttata cgattatagc agaaagaaag   287760
gcttttttca atgaagaaaa taagatgctt tctagcctaa agcgagcctt tcttatcggc   287820
tgagacactt tcagtcgatt ttttcttgct ttctgctcct aaaaaagata tactttgaca   287880
gtgaaataat ttaacactca atgaaaatca aagagcaaac taagaagcta gacgaagtca   287940
gctcaaaata ctgttttgag gttgcagatg gaagctgacg cggtttaaag agattttcga   288000
agagtataaa ctgcttataa aataaaaagg agccctgatg gaacacatta tttatcaact   288060
tgaagaggac ttggcaatcc ttaccttgaa ccgtcctgag gtcgcaaatg gttttcatat   288120
tcccatgtgt gaggagattt tagaagctct gactttggca gaagaaaatc cagctgtgca   288180
ttttatctta atcaatgcca atggaaaggt cttctcagtt gggggagatt tggtagagat   288240
gaagcgggca gtggatgagg atgatattcc atcattgaca aaaatcgcag agttggtcaa   288300
tacgatttct tataaaatca agcaaatagc caaacctgtt ttaatggaag ttgacggtgc   288360
tgttgcaggt gccgcagcga atatggctgt tgcggcagat ttctgtttgg cgacggataa   288420
ggctaagttt atccaagcct ttgttggtgt tggtttggct ccagatgcag gggggattca   288480
tctcttgagc cgcagtatcg gtgtgacgcg tgctgctcaa ttagctatga caggagaggc   288540
tttaacggca gaaaaagccc tagaatgggg gttggtttac cgcgtttctg aagctgaaaa   288600
acttgaaaag acgagagaac agcttcttaa aaaattaaga cgtgcttcaa gtaattccta   288660
tgctgccatt aagaagttgg tttgggagag ccaatttaaa gactggcagg gttacgctac   288720
tttagaactg aacctacaga aatccttagc tcaaacagag gatttcaaag aaggagtgcg   288780
agctcattcg gagagaagaa gacctaaatt tacaggaaaa taaaaaatac ttgcatcatt   288840
ctttgaattt tgatataatt ctttctgtca aatgttttga ttgtaaaagt tttttgaaga   288900
aggagggata tgaaaaatgg actaccaacg aatcaatgaa tatttaacat ctatatttaa   288960
caatgtcctt gtaattgagg aagtgaactt gagaggtagt cgttttaagg atatctccat   289020
caaagaaatg catacgattg atgtcatcgg taaggctcca gacgtgactc caagtcaagt   289080
gtcaaaagag ttgatggtaa ctcttggaac tgttacgaca agtttgaaca atttagagcg   289140
taagggctac attgagcgag ttcggtcaga acaggatcgt cgtgtggtgc atctgcattt   289200
gacaaagaag ggtcgcttga ttcatagact gcataaacgc ttccacaagg ccatggtaga   289260
aaaaattatt gatggcatga gcgaggaaga aattgctgtc atgggtaaag gtttgactaa   289320
tctttaccaa tttttggagg atttgaaata atggcttttg caaaaataag tcaggttgct   289380
cattatgtgc cagagcaagt ggttacaaat cacgacttgg ctcagattat ggataccaat   289440
gatgagtgga tttcaagtcg aacgggaata cgacaaaggc atatttcaag aacagaatct   289500
accagtgatt tggctacaga ggttgctaag aaactgatgg caaaagctgg aataacagga   289560
gaagaactgg attttatcat cctagctacc attactccag attcgatgat gccctctaca   289620
gctgctcgtg ttcaagctaa tattggtgct aataaagcct ttgcttttga cttaaccgcg   289680
gcttgcagtg gatttgtatt tgctctttca actgctgaaa agtttatcgc ttctggtcgc   289740
tttcaaaaag gcttggtgat tggtagtgaa accctctcta aggcagtcga ttggtcggat   289800
cgatcaacag ctgtgttgtt tggagatggt gctggtggtg tcttgttaga agctagcgag   289860
caagagcatt tcttagctga gagtctcaat agcgatggaa gtcgcagcga gtgtttaact   289920
tatgggcatt caggtttaca ttctccattt tcagatcaag aaagtgcaga ttcgtttttg   289980
aagatggatg gacgcacagt ctttgatttt gccattcgag atgtagccaa gtctatcaag   290040
cagactattg atgaatctcc tatagaggtg acagacttgg attatctgct acttcatcaa   290100
gccaatgacc gtattttgga taagatggct agaaaaattg gtgttgaccg agccaaactt   290160
ccagccaata tgatggaata tggcaatacc agtgcagcca gtatcccgat tttactttca   290220
gagtgtgtag aacaaggtct catcccttta gatggtagcc agactgttct tctatcaggc   290280
ttcggtggag gcttgacctg gggcacgctc attcttacaa tttaggtaat catgtggtga   290340
acacattgtt ataaaaaaac tatttatttt aaaggagtcc tatcatggca gtatttgaaa   290400
aagtacaaga aattatcgtt gaagaacttg gaaaagacgc atcagaagta acacttgaat   290460
caacttttga tgatttggac gcagattcat tggacttgtt ccaagtaatc tcagaaatcg   290520
aagatgcttt tgatatccaa atcgaagcag aaaatgactt gaaaacagtt ggtgacttgg   290580
ttgcttacgt tgaagagcaa gcaaaataag cagaatatta gtagaaggag tagggagaaa   290640
cccactccct cttgtttagg taatagtttg actgtcaaat tatggtgaaa tcgaactatt   290700
acgtaagcaa ggaaggttgg aggcactatg aaaacgcgta ttacagaatt attgaagatt   290760
gattatccta ttttccaagg agggatggcc tgggttgctg atggtgattt ggcaggggct   290820
gtttccaagg ctggaggatt aggaattatc ggtgggggaa atgccccgaa agaagttgtc   290880
aaggccaata ttgataaaat caaatcattg actgataaac cctttggggt caacatcatg   290940
ctcttatctc cctttgtgga agacatcgtg gatctcgtta ttgaagaagg tgttaaagtt   291000
gtcacaacag gagcaggaaa tccaagcaag tatatggaac gtttccatga agctgggata   291060
atcgttattc ctgttgttcc tagtgtcgct ttagctaaac gcatggaaaa aatcggtgca   291120
gacgctgtta ttgcagaagg aatggaagct ggggggcata tcggtaaatt aacaaccatg   291180
accttggtgc gacaggtagc cacagctata tctattcctg ttattgctgc aggaggaatt   291240
gcggatggtg aaggtgctgc ggctggcttt atgctaggtg cagaggctgt acaggtgggg   291300
acacggtttg tagttgcaaa agagtcgaat gcccatccaa actacaagga gaaaatttta   291360
aaagcaaggg atattgatac tacgatttca gctcagcact ttggtcatgc tgttcgtgct   291420
attaaaaatc agttgactag agattttgaa ctggctgaaa aagatgcctt taagcaagaa   291480
gatcctgatt tagaaatctt tgaacaaatg ggagcaggtg ctctagccaa agcagttgtt   291540
cacggtgatg tggatggtgg ctctgttatg gcaggtcaaa tcgcagggct tgtttctaaa   291600
gaagaaacag ctgaagaaat cctaaaagat ttgtattacg gagccgctaa gaaaattcaa   291660
gaagaagcct ctcgctggac aggagttgta agaaatgact aaaacagcct ttttatttgc   291720
tggtcaaggt gcccagtatc tagggatggg acgggatttc tatgatcagt atccgattgt   291780
taaagaaacg attgatcgag cgagccaggt gctcggttat gatttgcgtt atctcatcga   291840
tacggaagaa gacaaactca atcagacccg ctatacgcaa ccagccattc tagcgacttc   291900
ggttgctatc taccgtttat tgcaagaaaa gggctatcag cctgatatgg ttgctggttt   291960
gtctcttgga gaatactctg ccttggtggc aagtggcgcc ttggattttg aagatgcggt   292020
tgccttggta gctaagcgtg gagcctatat ggaagaagcg gctcctgctg actctggcaa   292080
gatggtagca gttctcaata cgccagtaga ggtcattgaa gaagcctgtc aaaaagcttc   292140
tgaacttgga gtggttactc cagccaacta taacacacct gcacaaatcg tcattgctgg   292200
agaagtggtt gcagttgatc gagcggttga acttttgcaa gaagcaggtg ccaaacgctt   292260
gattcctctt aaggtgtcag gtccctttca caccgctctc cttgaacctg ctagccagaa   292320
actagctgaa actctagctc aggtaagttt ttcagatttt acttgtcccc tagtcggcaa   292380
tacagaagct gctgtgatgc aaaaagagga cattgctcag ctcttgacgc gtcaggtcaa   292440
ggaacccgtt cgtttctatg aaagtattgg ggtcatgcaa gaagcaggca taagcaactt   292500
tatcgagatt ggaccgggga aagtcttgtc aggttttgtt aaaaaaattg atcaaactgc   292560
tcacttagct catgtggaag atcaagcgag tttagtagca cttttagaaa aatagactaa   292620
aataagtaga agttttgaaa ggaaaaaaat gaaactagaa cataaaaata tctttattac   292680
aggttcgagt cgtggaattg gtcttgccat cgcccacaag tttgctcaag caggagccaa   292740
cattgtctta aacagtcgtg gggcaatctc agaagaattg ctcgctgagt tttcaaacta   292800
tggtatcaag gtggttccca tttcaggaga tgtatcagat tttgcagacg ctaagcgtat   292860
gattgatcaa gctattgcag aactgggttc agtagatgtt ttggtcaaca atgcagggat   292920
tacccaagat actcttatgc tcaagatgac agaagcagat tttgaaaaag tgctcaaggt   292980
caatctgact ggtgccttta atatgacaca atcagtcttg aaaccgatga tgaaagccag   293040
agaaggtgct atcattaata tgtctagtgt tgttggtttg atggggaata ttggtcaagc   293100
taattatgct gcttctaagg ctggcttgat tggctttacc aagtctgtgg cacgcgaggt   293160
cgctagtcgg aatatacgag tcaatgtgat tgctccagga atgattgagt ctgatatgac   293220
cgctatcctg tcagataaga ttaaggaagc tacactagct cagattccga tgaaagaatt   293280
tgggcaggca gagcaggttg cagatttgac agtattttta gcaggccaag attatctaac   293340
tggacaagtg gttgccattg atggtggctt aagtatgtag cgaaagctag aggtgaaaag   293400
aatgaaacta aatcgagtag tggtaacagg ttatggagta acatctccaa tcggaaatac   293460
accagaagaa ttttggaata gtttagcaac tgggaaaatc ggcattggtg gcattacaaa   293520
atttgatcat agtgactttg atgtgcataa tgcggcagaa atccaagatt ttccgttcga   293580
taaatacttt gtaaaaaaag ataccaaccg ttttgataac tattctttat atgccttgta   293640
tgcagcccaa gaggctgtaa atcatgccaa tcttgatgta gaggctctta atagggatcg   293700
ttttggtgtt atcgttgcat ctggtattgg tggaatcaag gaaattgaag atcaggtact   293760
tcgccttcat gaaaaaggac ccaaacgtgt caaaccaatg actcttccaa aagctttacc   293820
aaatatggct tctgggaatg tagccatgcg ttttggtgca aacggtgttt gtaaatctat   293880
caatactgcc tgctcttcat caaatgatgc gattggggat gccttccgct ccattaagtt   293940
tggtttccaa gatgtgatgt tggtgggagg aacagaagct tctatcacac cttttgccat   294000
cgctggtttc caagccttaa cagctctctc tactacagag gatccaactc gtgcttcgat   294060
cccatttgat aaggatcgca atgggtttgt tatgggtgaa ggttcaggga tgttggttct   294120
agaaagtctt gaacacgctg aaaaacgtgg agctactatc ctggctgaag tggttggtta   294180
cggaaatact tgtgatgcct accacatgac ttctccacat ccagaaggtc agggagctat   294240
caaggccatc aaactagcct tggaagaagc tgagatttct ccagagcaag tagcctatgt   294300
caatgctcac ggaacgtcaa ctcctgccaa tgaaaaagga gaaagtggtg ctatcgtagc   294360
tgttcttggt aaggaagtac ctgtatcatc aaccaagtct tttacaggac atttgctggg   294420
ggctgcgggt gcagtagaag ctatcgtcac catcgaagct atgcgtcata actttgtacc   294480
aatgacagct gggacaagtg aagtatcaga ttatatcgaa gctaatgtcg tttatggaca   294540
aggcttggag aaagaaattc catacgctat ttcaaatact tttggttttg gaggccacaa   294600
tgcagttctt gctttcaaac gttgggagaa tagataagta tgaatttaaa cgatattaaa   294660
gacttgatga ctcaatttga ccagtcaagt ttgagagaat tttcttataa aaatgggacg   294720
gatgagttgc agtttagcaa gaatgaagca agacctgtgc ctgaagttgc aactcaagtc   294780
gctccagcac ccgttctagc aacaccgagt ccagtagctc ctacatctgc tccagcagag   294840
actgtagcag aagaagttcc agctccagct gaagcaagtg tggctactga gggaaatctt   294900
gtagagagtc cacttgttgg agtggtttac ttggctgctg gaccagataa acctgccttc   294960
gttacagttg gtgatagtgt caaaaaaggt caaacattgg taattatcga agccatgaaa   295020
gtcatgaatg aaatcccagc tcctaaggat ggtgtggtaa cggaaattct cgtctctaac   295080
gaagaaatgg ttgagtttgg taaaggattg gtacgtatca aatgatcgat attcaaggaa   295140
tcaaagaagc tcttccccac cgttatccta tgcttctagt ggaccgtgtc ttggaagtga   295200
gcgaggatac cattgttgct atcaaaaatg tgaccatcaa cgagcctttc tttaacggcc   295260
actttcctca atacccagtt atgccaggtg ttgtgattat ggaagccttg gcgcaaactg   295320
ccggtgtgtt ggagttatca aaacctgaaa ataaaggaaa actggtcttt tacgctggta   295380
tggacaaggt taagttcaag aagcaagttg taccaggcga ccaattggtt atgacagcga   295440
cttttgtaaa acgtcgtggc accatagctg tggttgaagc aaaggctgaa gtggatggca   295500
agcttgcagc cagtggtacc cttacttttg caattgggaa ctaaggaggt tctccatgtt   295560
tcgaaaaatt ttaattgcca atcgtggtga aattgcggtt cgtattatcc gtgcggcacg   295620
tgaattgggg attgcgacgg tagcggttta ttcaactgct gataaggaag ctcttcatac   295680
gcttttggca gatgaagcag tttgtattgg tcctggcaag gcaacagagt cttatctcaa   295740
tattaatgca gttctatcag ctgcagtctt gactgaggca gaagctattc accctggttt   295800
tggatttctc agtgaaaatt ccaaatttgc gaccatgtgt gaagaagtag gtatcaagtt   295860
tatcggtcca tctggtcatg ttatggatat gatgggggat aagatcaatg cgcgtgctca   295920
gatgattaaa gcaggtgtgc ctgttatacc aggttcagat ggagaagtgc ataactctga   295980
agaagctttg attgttgctg aaaaaattgg ctatcctgtt atgctcaagg cttcagcagg   296040
tggaggtggt aaagggattc gtaaggttga aaaaccagat gacctcgttt ctgcctttga   296100
aactgcctct agtgaggcca aggccaatta tggcaatggt gccatgtaca tagaacgggt   296160
tatctatcca gctcggcaca ttgaggttca aatcctaggt gatgagcatg gacatgtgat   296220
tcacttgggt gaacgggatt gttctcttca aaggaataac caaaaggttt tggaagaaag   296280
tccctcgatt gcaatcggaa aaacgctgcg tcatgaaata ggtgctgctg ctgttcgagc   296340
ggcagagttt gttggctatg agaatgcagg aaccattgaa tttcttcttg atgaagcaag   296400
tagcaatttc tatttcatgg agatgaatac tcgtgttcag gtagaacatc cagtaacaga   296460
gtttgtttca ggtgttgata tcgttaagga acagatttgc attgcggcag gtcagccttt   296520
gtctgttaag caagaagata ttgtcctacg cggtcatgcc atcgagtgtc gtatcaatgc   296580
agaaaaccca gcctttaact ttgctccaag tccaggtaag attactaatc tctatctgcc   296640
aagtggtgga gttggcttgc gcgtggattc agcagtttat ccaggttata ccattccgcc   296700
ttattatgat agtatgattg ccaaaatcat agtacacggc gaaaatcgtt ttgacgcctt   296760
gatgaaaatg caacgtgccc tctatgaatt agaaattgaa ggagtgcaga ccaatgcaga   296820
tttccagctt gacctcattt cagatcgcaa tgtcattgct ggggattatg atacttcctt   296880
cttgatggaa accttcttac ctaaatatca agaaaaagaa taaaatgact ttaagagttt   296940
aaaccgaaaa ggggaatcaa tggctctatt tagtaaaaaa gataagtata ttcgaatcaa   297000
tcccaatcgt tcggttaggg aaaaacctca agctaagcca gaggttccag atgaattatt   297060
ttcccagtgt ccaggctgta agcataccat ctatcagaag gatctgggaa gtgaacgtat   297120
ctgtccgcac tgtagctata cctttcgtat ttctgcccaa gaacgcttgg ctttgacgat   297180
tgatatggga accttcaaag aattgtttac agggattgaa agcaaggatc ccttgcattt   297240
ccctggttac caaaagaaac tggcatctat gcgtgaaaaa acaggtctgc atgaagccgt   297300
tgtgacagga actgctctta ttaaaggtca gactgtggct cttgggatta tggattctaa   297360
ctttatcatg gcttctatgg gtacggttgt aggtgaaaaa atcactcgtt tgtttgagta   297420
tgcgactgtc gaaaaattgc cagttgtcct attcacagcc tctggtggag cccgtatgca   297480
ggaaggaatc atgagtctca tgcagatggc taagatctct gcggcggtta aacgccattc   297540
aaatgctggt ctcttttacc tgaccatttt gacagatcca acgactggtg gtgtgacagc   297600
ttctttcgct atggaaggcg atatcattct ggctgaacca cagagcttgg ttggttttgc   297660
tgggcgtcgt gtgattgaaa atacggttcg tgaaagcttg cctgaggatt tccaaaaggc   297720
agaattccta ttagaacatg gctttgtgga tgctattgtc aaaagaagag acttaccaga   297780
tacgattgct agcctagtca gattgcatgg agggagtcct agatgaatat tgcaaaaata   297840
gtcagagaag cgcgtgagca gagtcgcttg acaaccttgg actttgcgac aggcattttt   297900
gatgaattta tccaattaca tggtgaccgt tcttttcgtg atgatggtgc agttgttggt   297960
ggtattggtt ggcttggaga ccaagctgta acagtggttg gtatccaaaa aggcaagagt   298020
ttgcaagaca acctcaaacg gaattttggc caaccacatc cagaaggcta ccgaaaggca   298080
ctgcggttga tgaaacaggc tgagaaattt ggccgtccag ttgtgacctt tatcaataca   298140
gcaggtgctt atcctggtgt cggagcggaa gaacgtggtc aaggggaagc tatcgctcgc   298200
aatctcatgg aaatgagtga cctgaaagtt cctattatcg ccattattat cggtgaaggt   298260
ggttcaggcg gggctctggc tctagctgtc gcggaccgtg tctggatgct ggaaaattct   298320
atctatgcca ttctcagtcc agaaggcttt gcttccattt tatggaagga cggtactcgc   298380
gctatggaag cagcagaact gatgaaaatc acttcgcatg aactgttaga aatggacgtg   298440
gtggataagg tgatttctga aataggactt tctagtaaag aactgattaa gagtgtcaaa   298500
aaagaactcc aaacggagct ggctagactt tcacaaaaac cgctagaaga gttgctggaa   298560
gaacgctatc aacgatttag aaaatactaa gaatgactaa atgagactag aaaggtctca   298620
ttttttatgg aaaaatgtaa ttcaggtcga aaaattgcca gttgaggaga tgggctataa   298680
aatagacaaa aaaagaaata tactataaat gtgagcctac aacaatctat tttaagaagg   298740
tacttgcaat gacaggtaca aatacattta cagttctttc aactgaggac ttggagcaaa   298800
cttcaggtgg tcttgctgtt tgggaagatg gatatagtag atggttatat tatagagaat   298860
ttgctcccta tatgaggcaa ggggcactta attcttatat agatgcttgg aagtacggct   298920
tccgagcagg gtaatctttc aaaaaagtac gatgagaaac acaaaaaaac taagacaatt   298980
tggaatattt ttgcttatta ttttactatc tacctattta ccacaaacaa ttggattgta   299040
tgtgacgatc attttagggt taggagctga tgtctattct cttattttaa caatgggatt   299100
agtgggaagt ttccttctat taatttggag gttaaaaaag aaaaagatgc tctttatctt   299160
tgagaaaaag agctggaact ggtcatttgt cttctactta tttgcaactt atgtggttta   299220
tcagattctc ggtaattttt gggcacgcta tgctcatttg attaatcata ggaatattca   299280
tgatgagtat tttaccgtgc ttttttcaaa tggacaacca acctttttat cgactatctt   299340
atcttttgtc ctgcctgtaa tcatcggtcc tgtttttgag gagactcttg atagagggta   299400
ttttatgaat accttctttc cctagtccaa gtactatttg gatgttatcc tatctgctat   299460
catctttggg attagccatt tgatactatc tcacagagat ccaattagtt tattatatta   299520
tagtctgatt ggtttctttt ttgcccttgt ttatcgttct accgacaatc tgagattaac   299580
gattctctgc catagttttt ttaactttct caatcatgca aaacctatct ggatttttgt   299640
ttacaattat atctattatc atttttttag atagtgggag gcaaagaaaa aagtgtttga   299700
tatctatcaa acactttttc tttttattgt tggctctata atatttgtag tgggtaaatc   299760
ccctatagat attatggagc ctattttatt gtagaaaaaa agtcccatat gacctataat   299820
gaaaagcgac aaaacaactc attagaaaga ttcatatgga acaattacat tttatcacaa   299880
aattactaga cattaaagac cctaatatcc agattttaga catcatcaat aaggatacac   299940
acaaggaaat catcgccaaa ctggactacg acgccccatc ttgccctgag tgcggaaacc   300000
aattgaagaa atatgacttt caaaaacctt ctaaaattcc ttatcttgaa acgactggta   300060
tgcctactag aattctcctt agaaagcgtc gattcaagtg ctatcactgt tcaaaaatga   300120
tggtcgctga aacttctatc gtcaagaaaa atcaccaaat ccctcgtatc atcaaccaaa   300180
agattgctca aaagttgatt gaaaagattt ctatgactga tattgcccat cagctttcca   300240
tctcaacttc aactgttatt cgtaagctca atgattttca ctttaaacat gatttttctt   300300
gtcttcctga gattatgtct tgggatgagt atgcttttac aaagggaaag atgagcttca   300360
ttgcgcaaga ttttaacaat ctcaatatca tcactgttct tgagggtaga acacaagcta   300420
tcattcgaaa tcactttctt cgctacgata gagttgtccg atgtcgcgtc aaaattatta   300480
ctatggatat gtttagccct tactatgact tggctaaaca gcttcgcttt caaattccta   300540
ggctcaggct gaaacagtct cccagactgt ttcactcccg aatgctaaaa tcgttcttga   300600
tcgctttcac attgtacaac atcttagccg tgccatgagt cgtgtgcgtg tccaaatcat   300660
gaatcagttt catcgaaaat cccatgaata caaggatatc aagcgctact ggaaactcat   300720
tcaacaggat agccgtagac tgagtgataa gcgattttat cgtcctactt ttcgtatgca   300780
cttaaccaat aaagagattt tagacaagct tttgagccat tcacaagact tgaaacacca   300840
ctatcagctc tatcagctct tgctgtttca cttccagaat aaggaaccag agaaattttt   300900
cggacttatt gaggacaatc ttaagcaggc tcatcctatt tttcagactg tctttaaaac   300960
cttcctcaaa gataaagaaa agattgtcaa cgcccttcaa ctacactatt ctaatgccaa   301020
actggaagcg accaataatc tcatcaaact tatcaagcgc aatgcctttg gttttcgaaa   301080
ctttgaaaac ttcaaaaaac ggatttttat cgctttgaac atcaaaaaag aaaggacgaa   301140
atttgtcctt tctcgagctt agcttttttt caacccacta cagttgacaa agagccttat   301200
tgttcttctg ttacaaactg gctgagcagt ccattgataa aacgggcaga tttttgatcg   301260
gagaagtcct ttgcaagctc gatagcttca ttaacagcaa ccagctgagg agtgtcaaat   301320
gaagtgattt caaagactcc caagcgaagg aggtttctct ccacgagcgt taagcgttca   301380
atggtccaac ctgcttttaa atgctgagtg atttgcttat ctagttcttc ctttttagct   301440
tgaacaccag aaacgaggtc tatcaaaaag gctggaagtt gtacatccgt atcttcacga   301500
tcatgagtat aggcgaaacg acaagcagtt tcgacatccg taccgaactc aaggctcatg   301560
agagcttgaa aagcgcattt acggagttgg cgtctagatt ctaatagtgg actagtcatt   301620
gaggaagtcc tcgtcaaata gatctttcaa ttctggtttt ggtgttttat ctgggacgat   301680
acctgcaacg tgaatattga tagcagcgag ttctacatca gccatattac ggacggcatc   301740
tttgacagct ttctggatag caaccgctac cttaggaact tttactccgt actcaaggta   301800
gagatagata tctgctgtga gttcttcgtc cacgttttta agataaatgc cacggccgag   301860
tgaaagtttt gaaagggtat cagacactga tctgtttgaa aaagagtgaa caccctctac   301920
ctttgcagta gcgatagcaa tgattttttc aagtacacgt ggggcgataa cgatttcgcc   301980
aagttgttct tcaattccca tagaatgacc tctttctaga gattaggcac gagaaacgta   302040
agttccttct gcagtgttga taacgagttt ttgtcctgct tcgatgaagt ctggaacgtt   302100
tacgacaagt ccagtttcca tcgttgctgg tttaccagaa cctgtaacag tagcaccttt   302160
gatagatggt tgagtttcag caactgtcaa ctcaacagta gtaggaacgg tgacaccgat   302220
cacttcagtt ccgtagaatt ggattttcac atcagagttt tcaaggatgt aaagcaattc   302280
gttttcaaca ttgactacag ggatttcgta ttggtcataa gtttctgtat tcatgaagta   302340
tgctgtgtca tccattttgt acaagtattg agctgggaca gtctcgataa tagcttgttc   302400
aaatttttcc tctggacggt agcttgtgtc aaatgtagaa ccagtacgga catcacgcaa   302460
tttcatacgc atgatcgtgt ttcctttacc tggtttgtgg tgactagctt ccaaaacgcg   302520
aatcaatttg ccgtcagctg tttcaaaggt cataccagct tttaatttac ttgcttcaat   302580
catgttttta cctctttaat aaatattatt actcttcatt ttaccataaa atactctgga   302640
aataaagcca aaatagttat tgggagttgg tagagaagaa aaaaccaacc ttagggctgg   302700
ttttgttctg tctagttttc tttcaacttc gccaattcct gtgcaagtag tttaagggca   302760
acttgtgggt tggcttggcc tttggttgcc ttcataagga atcctgtaaa ggccttgtcg   302820
gcgttacgtt tgcctgactt gaagtcggca acagcagctt cgttatcggc aaagacttgg   302880
tggatgattg ggatcaagat agctggatct gaaatttgaa ccatacctgc tttttccacg   302940
tattcacgcg cgccaccgcc atttttagct agatggacaa agactttctt ggcaatctta   303000
gatgaaatag taccgtcttc gatgatggca atcatttcaa ccaagttttc tggtgtcaat   303060
tcgatttgtt ccagtgtttt accttcagca ttcaagaact gagcgacttc cccttggagc   303120
cagttagaga cttgtttggc atcaccacct agggcaacag ctttttcaaa gaagtcagaa   303180
gtgactttat tagcagtcaa ctgactagca tcgtagtctg ataaaccaag gtcagataca   303240
taacgcgcac gacgttcttt tggaaactct ggcaactcag tccgcatttc ctcaatccac   303300
tcgtcagaaa tttcaaagag gggtaggtct ggttctggga agtagcggta gtcagcagcc   303360
ccttccttga cacgcatgag gatggttgct ttattcgctt catcgtaacg gcgtgtttct   303420
tggcggattt gaccacctga gcgaagaatt tcagcctggc gttggacttc gtattcaaga   303480
cctttacgaa cgtttgagaa ggagttgagg ttcttcaatt cagtcttggt accgaatttc   303540
tcttgaccat aaggacgaag ggagatgttg gcatccacac gcatcgaacc ttcctccatc   303600
ttaacgtcag aaatgccagc gtactggata acttccttga gggctgtcag ataagcatag   303660
gcttcttcag gagaacgcat atctgcctca gatacaatct caatcaaggg aaccccttgg   303720
cggttgaggt caacataaga gtagccatct gtaccatggg tgtttttacc agcgtcttcc   303780
tctaggtggg cacgttcgat accgattttc ttggtcgtac cgtcttctag tttgacttca   303840
atccagccat tatatccgat tggttcatca aactgagaaa tttggtaggc tttggggtta   303900
tcaggataga agtagttctt gcggtcaaag tgcatctttt tgtggatgtc catgttgagg   303960
gcaagagcag ccttgatacc ggcatcaaca acccctttat tgagaactgg tagaactcct   304020
gggaaagacc agtcaatcac gttagtgttg gcattttggt catttccaaa gtgggcagaa   304080
gtaggtgaga agatttttga attggtgttg agctctacgt ggacttcaag tccgatgact   304140
gtttcaaagt tcattagttg tcacctccaa aaatcacggg ttgttgtttg tggtagtctg   304200
ttgttgcttc aaaagcagca gcagcttggt aaatggtttc ctcagagtac ttgggaccaa   304260
tcaattggag tccgacaggt agaccttgag agaatccagc aggaatcgaa attccaggca   304320
gtcctgccaa gtttacaggt atggtcaata ggtcggctaa gtacatggca actgggtcat   304380
ggttgagaga atccaagtca taggcaacac ttggagcagt tggacccaaa atcaaatcgt   304440
aatccgcgaa gactttttcg aaatcttgaa tgatgagggt acggacttga ccagcctttt   304500
tgtagtaggc atcatagtaa cctgatgaaa gactgaaagt acccagcatg atacgacgtt   304560
ttacctcttc accaaaacct tggcttcggc tgtttacata gatttcatca aggttggttg   304620
catcttctgc gcgatagccg taacggatac cgtcgaagcg ttgcaagttt gatgaagctt   304680
ctgatgaagc gatgatgtaa taaacggcaa caccgtattt agagtgagga aggctgactt   304740
cttcgacgat agcacccaat ttttcaaagt gtttggccgc gtttaagatt gtttccttaa   304800
cctctggatc aattccttcg cctaggtatt ccttaggcaa agcgattttc atacccttga   304860
tgtcttggcc gatttttgaa gtaaagtcgg cgatgcggac aggagcagaa gtagagtctt   304920
tagcatcttc gctggcaata gcgttgagca agagggcatt ttccttaaca gtaggagcaa   304980
aaggtccaat ctggtctaat gagctaccaa aggcaatgag accgaaacgt gaaactgttc   305040
cgtaggttgg tttgagacca acgattccgt tgaaggcagc aggttggcgg atggaaccac   305100
cagtatcaga accaagtgac aagcgaactt gtcctgaggc tacagctgcg gcagaaccac   305160
ttgatgaccc accaggaacc ttgctgtggt tccaagcgtt tttagttgct ccgtagtgtg   305220
aagtttcacc tgaaccaccc atagcaaatt cgtccatgtt ggtctttcca acgacaatca   305280
tgcccttggt ttttgcattg gcaacagctg tcgcatcaaa gattggctca tagttgtaga   305340
gcatttttga ggcagcagtt gtgagaatac cgtctgtaga gatgttatcc ttaacagcaa   305400
gtggaattcc tgaaaggaca ttgtcagcat caattccagc ttcatcaatg gctttagctt   305460
gaacaagagc ttgctcctca gcgatggtga caaatgaatt gagggcttcc tcacgagact   305520
tgatattttc aagtgttgct tgggtcaatt ctgttgcaga aatttcctta gagacaagga   305580
gattgtgcaa ctcttcaata gttttattgt taaaagtcat taggcatctc ctccattgtc   305640
taggatagct ggcaccttga tatagtagtt gtctttttca ggtacgtttt taaacaagcg   305700
atcacggtct attccttctt cggccacatc agggcggagt acagtcttgc ggtcagccat   305760
agtcgtagta ggtgcgacac cagttgtgtc aacttcgccc agcaattcaa ccatgtcaac   305820
aatcttagac aaggtggtcg caaaggcagc agtttcttct tcagagaatc ttaattttga   305880
aagattggca acgtgtgtta cctcttcttg cgtaattttc atcttgcatc ctttcgtgaa   305940
atgatgattt ttagtctgtt ctattttacc atattttcct ataaataagg gagggggaag   306000
tgaaaagaaa tagaaattga aaaaaatgct aaaatccgat ataatggagt gttgaaagga   306060
atggtaaaat ccaatgtaaa aatcattctc agctattgaa acaagaaaaa tagagaatca   306120
aagaaagaga acttatgaat attcaagaag aaattaagaa acgtcgtacc tttgccatta   306180
tctcccaccc ggacgcgggg aaaacaacca tcactgagca gttactctac tttgggggtg   306240
agattcgtga ggctggtacg gtaaaaggga agaaaacagg gacttttgct aaatctgact   306300
ggatggatat cgagaagcaa cgtgggattt ctgttacttc atctgttatg caatttgact   306360
acgacggcaa gcgcgtgaat atcttagaca cgccagggca cgaggacttc tcagaagata   306420
cctatcgtac cttgatggcg gtggatgctg cggtcatggt cgtggactct gccaagggga   306480
tcgaggctca aaccaagaaa ttgtttgagg ttgtgaaaca tcgtggcatt ccagtcttta   306540
cctttatgaa caagctggac cgtgacggtc gtgagccttt ggatctcttg caagaattgg   306600
aagaaatctt gggcattgct agctacccta tgaactggcc tatcgggatg gggaaagcct   306660
ttgagggctt gtatgacctc tataaccaac gtttagagct ttacaaaggg gatgagcgtt   306720
ttgccagtct agaagacggg gacaaactct ttggtagcaa tcctttctac gagcaagtca   306780
aggatgacat tgagctttta aatgaagccg ggaatgagtt ttcagaggaa gctattctgg   306840
ctggagaatt gacgcctgtc tttttcggtt cagccctgac aaactttggt gtgcagacct   306900
tccttgaaac cttcctcaag tttgctccag aaccacatgg tcacaagaaa acagacggtg   306960
aaattgtgga tccttatgac aaggatttct caggctttgt ctttaaaatc caagccaaca   307020
tggaccctcg tcaccgtgac cgtattgcct ttgtccgtat cgtatctggc gaatttgagc   307080
gcggcatgag tgtcaatctc cctcgtactg gtaagggggc taaactatct aatgttaccc   307140
agtttatggc ggagagtcgt gagaatgtga ccaatgccgt ggcaggtgat attatcgggg   307200
tttacgatac cggtacttat caggttgggg ataccttgac ggttggaaaa aacaagtttg   307260
aatttgaacc cctgccaacc tttacacctg agattttcat gaaagtttct gctaagaatg   307320
ttatgaagca aaaatccttc cacaagggga ttgagcaatt ggtgcaagaa ggagccgttc   307380
agctttataa gaattaccaa acaggtgagt acatgctagg cgctgtaggt caactccagt   307440
ttgaagtctt taaacaccgc atggaaggcg agtacaatgc ggaagtagtt atgaacccaa   307500
tgggtaaaaa gaccgttcgt tggatcaagc ctgaggactt ggatgaacgg atgtcgtcaa   307560
gtcgcaatat cttagccaaa gaccgttttg accaaccagt ctttctcttt gaaaatgact   307620
ttgccctccg ctggtttgcg gacaagtatc cagacgtaga gttagaggag aagatgtgac   307680
tcagtaccaa caattggaac taaagttcca aattgttgga cgctagtcgc tatttggcga   307740
actagctaac tgcctcacta actacgtttg gcaaatgaaa tcgatttgta aaactccgtg   307800
tcgtaatgta aaaattgtaa accgtaatgg gacttcatct aaaatctcca ctggtatggt   307860
tttacgaacg aataggcgaa aataatggtt acgtagaaac atatgatggg aaacatatga   307920
tgggaataat atgatgggaa taaaaagaaa tgagataaaa agtgaaagaa gagaaaaaag   307980
cgattgtctt aggtgcagat aatgcttata tggataaagt tgaaacaaca ataaaatctc   308040
tttgtgttca tcattataat cttaagtttt atgtttttaa tgatgacctt ccgcgagaat   308100
ggttccaatt gatggaaaaa agactagaga ctttgaatag tgagattgtg aatgtttaga   308160
ttgacagtaa tattctgaaa ggttatcgtc tcccctttga gggactttca tatgcggctt   308220
ttttaggtat tttattccaa agtatgtaag cgagtctcgt gtactgtatt tggattcaga   308280
tattgttgta agaaaatcga tagatgagct gtgggatttg gacttgacgg ctataccctt   308340
agctgcagtt agagatgatt tttatacaca taattttaat tctggtgttc tgttaatcaa   308400
cgatggcatg tggagagcag aaaatgtcac gcaagacctg atttaagaca caaataaaaa   308460
atcttccaat tcccttgcaa aaaacaagaa aatgtgataa catagtacgg tatgtggtgc   308520
tagcacatcc gctatattag atctaatagg aggaaaacac aatggctaaa gtatgttact   308580
ttacaggtcg taagactgta tcaggaaaca accgttcaca cgcgatgaac caaacaaaac   308640
gtgccgtaaa accaaacctt caaaaagtta ctgttcttat cgatggtaaa cctaaaaaag   308700
tttgggcttc agctcgtgct ttgaaatcag gtaaagttga acgcgtttaa taataaaagc   308760
aaaggagacc ttagggtctt ttttctttta ttgtgggtat aacatcgttt gaaaaataga   308820
gtaaatatcc gctgatacat cattctgctt ttacacttgg gctgaaatat gataaaatag   308880
agtatcaact agttgaggta aaaaggatga ctgtaaaaat taatacaaaa gatggtcaaa   308940
tcgaactaac agatgaagtg attgcaaccg tcgtaggtgg agcagcaact gagatttttg   309000
gtgtggtcgg tatggctagt aaaaatgccc tcaaagataa tttccaagcc ctgctaggta   309060
aggaaaatta ttctaaaggt gtcgtcgtaa aggcagccga agatggcagt attgcagttg   309120
atgtatatac cgtgttaagc tacggaacaa agattagtga agtgtcaaaa aacattcaag   309180
agcgtgttgc ctttagcttg gaaaaccagc ttggaattac tgctcagact gtaaatgtct   309240
acattcaaaa tatcaaagtt gtaggagaat aaccgtgtca aaaattacta ctagcttatt   309300
tcaagaaatg gtgcaggctg catcaactcg cttgaataag caagctgaat atgtcaattc   309360
attaaacgtc tttccagttc cagatggaga tactgggaca aatatgggaa tgaccattga   309420
aaatggtgct aaagaagttg cagacaagcc agcttctaca gttggagaag tagcgagcat   309480
tcttgccaaa gggcttttga tgggtgcgcg tgggaactca ggagtgatta cgtctcagct   309540
tttccgtgga ttttcccaag ctatcaagga taaagacgag ttaacaggtc aagacttggc   309600
tctggccttc caatcaggtg tggaagttgc ctataaggca gtgatgaaac ctgttgaagg   309660
aacgatttta acagtttctc gtggagctgc tatcggtgct aagaaaaaag ctgagcaaac   309720
agatgacgct gttgaagtca tgcgcgcagc cttggaaggt gctaaaacag ctctagctaa   309780
aacaccagac atgcttccag tattgaaaga agttggcgtt gtggactcag gtggtcaagg   309840
attggtcttc atctacgaag gtttcctttc agcccttact ggcgaatata ttgcatctga   309900
ggactttgta gcgactcctg ccaacatgag tgagatgatc aatgtagagc atcataagtc   309960
tgtagctggt cacgtagcga ctgaggacat cacgtttggt tactgtactg aaatcatggt   310020
agctcttaag caaggtccaa cctatgctaa agattttgac tacgatgaat tccgtaacta   310080
cttggatgag cttggagatt ctctccttgt tgttaacgat gatgaaattg tcaaagtcca   310140
tgttcataca gaagatccag gacttgttat gcaagaaggt ctcaaatatg gtagcttggt   310200
caaggtaaaa gttgacaata tgcgtaacca acacgaagca caggttgaga aagaagctac   310260
tcaagttatc aagtcggctg aagaaaaaga gtatgctttg attgctgtgg tggctggtaa   310320
aggtctagca gatatcttct gttctcaagg cgtggattat gttatcgaag gcggtcaaac   310380
catgaaccct tcaacagaag actttatcaa ggctgttgaa caggttaatg cccgtaacat   310440
catcttcttg ccaaacaaca agaacatctt catggcagct caatctgcgg cagaagtttt   310500
ggagcaacca gcggtagtgg tagaggctcg cactcttcct caaggtatga caagtcttct   310560
tgcctttgat ccaagcaagt ccattgaaga aaaccaagag cgtatgacag ctgctcttag   310620
cgatgtcgtt agcggaagcg tcacaacagc cgtgcgtgat acaacgatcg atggcttaga   310680
aatccatgaa aacgataatt taggtatggt ggatggaaaa attcttgtgt caaaccctga   310740
tatgcaccaa acattgactg aaaccttgaa acatatgttg gatgaagaca gtgaaatcgt   310800
aaccttctat gtaggtgaag acggaagcga agaacttgcc aatgaaatcg ctcaagaaat   310860
cgtagaagaa ttcgaagacg ttgaagtcga gattcaccaa ggtcaacaac ctgtttaccc   310920
atacctattt agtgtggaat aagattaatg aaggactgag aaatcagttc ttttttcttt   310980
ttagtaaatg aaatcggtat ctttttaata aaaacaaaaa taacattcat aaataaacgt   311040
taaaatagaa aattcagaaa atttcttctt ttatcttgaa aaattttgaa aaaatggtat   311100
gatagtaaca agttattttt aagaggaaag aaaggggaat aatggagaaa atcagtttag   311160
aatctcctaa gacggggtcg gacctagttt tggaaacact tcgtgattta ggagttgata   311220
ccatctttgg ttatcctggt ggtgcggttt tgccttttta tgatgcgata tataatttta   311280
aaggcattcg ccacattcta gggcgccatg agcaaggttg tttgcatgaa gctgaaggtt   311340
atgccaaatc aactggaaag ttgggtgttg ccgtcgtcac tagtggacca ggagcaacaa   311400
atgccattac agggattgcg gatgccatga gcgatagcgt tccccttttg gtctttacag   311460
gtcaggtggc gcgagcaggg attgggaagg atgcctttca ggaggcagac atcgtgggaa   311520
ttaccatgcc aatcactaag tacaattacc aagttcgtga gacagctgat attccgcgta   311580
tcattacgga agctgtccat atcgcaacta caggccgtcc agggccagtt gtaattgacc   311640
taccaaaaga catatctgct ttagaaacag acttcattta ttcaccagaa gtgaatttac   311700
caagttatca gccgactctt gagccgaatg atatgcaaat caagaaaatc ttgaagcaat   311760
tgtccaaggc taaaaagcca gtcttgttag ctggtggtgg aattagttat gctgaggctg   311820
ctacggaact aaatgaattt gcagaacgct atcaaattcc agtggtaacc agtcttttgg   311880
gacaaggaac gattgcaacg agtcacccac tctttcttgg aatgggaggc atgcacgggt   311940
cattcgcagc aaatattgct atgacggaag cggactttat gattagtatt ggttctcgtt   312000
tcgatgaccg tttgacgggg aatcctaaga ctttcgctaa gaatgctaag gttgcccaca   312060
ttgatattga cccagctgag attggcaaga ttatcagtgc agacattcct gtagttggag   312120
atgctaagaa ggccttgcaa atgttgctag cagaaccaac agttcacaac aacactgaaa   312180
agtggattga gaaagtcact aaagacaaga atcgtgttcg ttcttatgat aagaaagagc   312240
gtgtggttca accgcaagca gttattgaac gaattggtga attgacgaat ggagatgcca   312300
ttgtggtaac agacgttggt caacaccaaa tgtggacagc tcagtattat ccctaccaaa   312360
atgaacgtca gttagtgact tcaggtggtt tgggaacaat gggctttgga attccagcag   312420
caatcggtgc taaaattgct aacccagata aggaagtagt cttgtttgtt ggggatggtg   312480
gtttccaaat gaccaaccag gagttggcta ttttgaatat ttacaaggtg ccaatcaagg   312540
tggttatgct gaacaatcat tcacttggaa tggttcgcca gtggcaggaa tccttctatg   312600
aaggcagaac atcagagtcg gtctttgata cccttcctga tttccaattg atggcgcagg   312660
cttatggtat taaaaactat aagtttgaca atcctgagac cttggctcaa gaccttgaag   312720
tcatcactga ggatgttcct atgctaattg aggtagatat ttctcgtaag gaacaggtgt   312780
taccaatggt accggctggt aagagtaatc atgagatgtt gggggtgcag ttccatgcgt   312840
agaatgttaa cagcaaaact acaaaatcgt tcaggagtcc tcaatcgctt tacaggtgtc   312900
ctatctcgtc gtcaggttaa tattgaaagc atctctgttg gagcaacaga agatccgaat   312960
gtatcgcgta tcactattat tattgatgtt gcttctcatg atgaagtgga gcaaatcatc   313020
aaacagctca atcgtcagat tgatgtgatt cgcattcgag atattacaga caagcctcat   313080
ttggagcgcg aggtgatttt ggttaagatg tcagcgccag ctgagaagag agctgagatt   313140
ttagcgatta ttcaaccttt ccgtgcaaca gtagtagacg tagcgccaag ctcgattacc   313200
attcagatga cgggaaatgc agaaaagagc gaagccctat tgcgagtcat tcgcccatac   313260
ggtattcgca atattgctcg aacgggtgca actggattta cccgcgatta aaaatccaac   313320
ttaaatttat taaaccagcc taaaaggcaa taaataatag aaaagagaga aaagctatga   313380
cagttcaaat ggaatatgaa aaagatgtta aagtagcagc acttgacggt aaaaaaatcg   313440
ccgttatcgg ttatggttca caagggcatg cgcatgctca aaacttgcgt gattcaggtc   313500
gtgacgttat tatcggtgta cgtccaggta aatcttttga taaagcaaaa gaagatggat   313560
ttgatactta cacagtagca gaagctacta agttggctga tgttatcatg atcttggcgc   313620
cagacgaaat tcaacaagaa ttgtacgaag cagaaatcgc tccaaacttg gaagctggaa   313680
acgcagttgg atttgcccat ggtttcaaca tccactttga atttatcaaa gttcctgcgg   313740
atgtagatgt cttcatgtgt gctcctaaag gaccaggaca cttggtacgt cgtacttacg   313800
aagaaggatt tggtgttcca gctctttatg cagtatacca agatgcaaca ggaaatgcta   313860
aaaacattgc tatggactgg tgtaaaggtg ttggagcggc tcgtgtaggt cttcttgaaa   313920
caacttacaa agaagaaact gaagaagatt tgtttggtga acaagctgta ctttgtggtg   313980
gtttgactgc ccttatcgaa gcaggtttcg aagtcttgac agaagcaggt tacgctccag   314040
aattggctta ctttgaagtt cttcacgaaa tgaaattgat cgttgacttg atctacgaag   314100
gtggattcaa gaaaatgcgt caatctattt caaacactgc tgaatacggt gactatgtat   314160
caggtccacg tgtaatcact gaacaagtta aagaaaatat gaaggctgtc ttggcagaca   314220
tccaaaatgg taaatttgca aatgactttg taaatgacta taaagctgga cgtccaaaat   314280
tgactgctta ccgtgaacaa gcagctaacc ttgaaattga aaaagttggt gcagaattgc   314340
gtaaagcaat gccattcgtt ggtaaaaacg acgatgatgc attcaaaatc tataactaat   314400
tagaaatata tagcgctgga gatgatttta tgaaaaagat tatgagaaaa attgcatcgt   314460
tattattggt tctagttgta taatgtaatt acaccgtcgg taatagtgct agcagaccaa   314520
aataaagcag attggtcgta tgatgaaaat gctgtaatta acatttatga tgatgctaat   314580
tttgaagatg gtaggttgca tatgaacttt gaacaattct tcaaattggc acaaatagct   314640
agagaagaag gtcttgaaat tcattctccg tttgagagag ctggtgcgac taaatctgct   314700
cgttatatag cgaaatggat tttgagaaat aaaaaacatt aacaaatata gttggtaaat   314760
cattaggacc taaatcagct gttagattcg gagaagcttt atcctatatt gaaggtcctc   314820
ttcgcagaat aaatgagacg atagatggcg gtttatatca aatagagcaa attattgcat   314880
ctggattgaa agaatcgggt ttaaatgact ggactgcgaa aactttagct tcagctattc   314940
gtgggatatt agatgtactt atttaggggt tgaaatcata tgaatattac caatttgttt   315000
tctatcaaga caggatgtga tgaaactgat aggcaactgc aaaaactatt ttttcagttg   315060
gatttacaat tgggagaatt gacagatcaa ctaagaaaat tagattctaa ttttgttcct   315120
cgtagtcaat ttgtagacac gttggatttg aatgatgtag aatataaaga aattttaaac   315180
tattttatct tccatcgtaa tgatagtgaa gaaagtttgg tagaatggtt atatgattgg   315240
atttccacaa atcgttatga acttcctaaa gagttttcga ttcgtatggc tcataaatac   315300
catgaaagtg ttactgaagt tttcggagat gaataactaa aaaacagtca ttagtgactg   315360
ttttttatag aaaaagaggt tttatatgtt aagttcaaaa gatataatca aggctcacaa   315420
ggtcttgaac ggtgtggttg tgaatactcc actggattac gatcattatt tatcggagaa   315480
gtatggtgct aagatttatt tgaaaaaaga aaatgcccag cgtgttcgct cctttaaaat   315540
tcgtggtgcc tattatgcca tttcccagct cagcaaggaa gaacgtgaac gtggggtagt   315600
ctgcgcttct gcgggaaatc atgcgcaggg agtagcctat acttgtaatg aaatgaaaat   315660
tcctgctact atctttatgc ccattactac gccacaacaa aagattggtc aggttcgctt   315720
ttttggtggg gattttgtaa ctattaaact agttggagat acctttgatg cctcagccaa   315780
agcagctcaa gaatttacag tctctgaaaa tcgtaccttt attgatcctt ttgatgatgc   315840
tcatgttcaa gcaggtcaag gaacagttgc ttatgagatt ttagaagaag ctcgaaaaga   315900
atcgattgat tttgatgctg tcttggttcc tgttggtggt ggcggtctca ttgccggggt   315960
ttctacctat atcaaggaaa caagtccaga gattgaggtt atcggagtag aggcgaatgg   316020
agcgcgttcc atgaaagctg cctttgaggc tggaggtcca gtaaaactca aggaaattga   316080
taaatttgct gatgggattg ctgtgcaaaa ggtaggtcag ttgacctatg aagcaactcg   316140
tcaacatatt aaaactttgg taggtgtcga tgagggattg atttctgaaa ccttgattga   316200
cctttactct aagcaaggga tagtcgcaga acctgctgga gcggctagta tcgcctcttt   316260
agaggtttta gctgaatata ttaaggggaa aaccatttgt tgtatcattt ctggaggaaa   316320
taatgatatc aaccgtatgc cagaaatgga agagcgtgcc ttgatttatg atggtatcaa   316380
acattacttt gtggtcaatt tcccacaacg tccaggagct ttgcgtgagt ttgtaaatga   316440
tatcctgggg ccaaatgatg atatcacacg ttttgagtat atcaaacgag ctagcaaggg   316500
aacaggccca gtattaattg ggatcgcttt agcagataag catgattatg caggtttgat   316560
tcgtagaatg gaaggttttg atccagctta tattaactta aatggtaatg aaacgcttta   316620
taatatgctt gtctgaggac taataaaaaa atatcatacc ttcattttga tttcctatct   316680
attgacaagc atagtcacac tgtctttaat actcttcgaa aatctcttca aaccacgtta   316740
gctctatctg caacctcaaa acagtgtttt gagcaacttg cggctagctt cctagtttgc   316800
tctttgattt tcattgagta taaggtatga tttgatttct ttttgttgac aaatatacta   316860
tattaaaaag atatataagt aattaactga gcttatctgt cttgtcatct ctattaagga   316920
tggtttagat aatcgggtgt ctgcttctag gctagcacct caatatccaa aggagtgatg   316980
aatttgaagg acataaggaa tacctatctc tcagatgatt tattgaggaa gaaagatagg   317040
agtttttgag ctagtgaagg cttggatttc taaaggttag aactatcatc ttcagttctt   317100
aaatcgaaga aataagctat cttacggaaa tagagaagca ttttttaaga acttgaataa   317160
tttcgcacct taagagggta ataatacagt atttttatta gcaaatattt atggtgtaga   317220
ggctagcaaa acctatatat tatcggattt aaaaaggaag taagaaaatt ctgaactaat   317280
tattttcgtt gaatatatgt tttttttatt gacaaaagta gtaaaaacgt atacaattaa   317340
atattataaa gaagaaaata ggagaaaaac atggctaagt caaactttga aaaagtagaa   317400
tcagttgttg gctgggttcg tgataagaaa atcacaggct accgtatctc taaagaaacg   317460
aatgcgcgtg aaatgtctat cattgctctg gcgcagggtc gtgcaaaagt aaaaaatatt   317520
tcatttgaaa cagccctagg cctaattgat ttctatgaaa aaaattatga aaaatttgaa   317580
gattaatctt tggataacgg cggattcttg accttcaagt agtagagata gagaatctgc   317640
cttttcattt tgaggacagc aaaaagactg cacggttgat gcagcctttt ctttttattt   317700
gagatagcgt tgaaggaact cttttgttcg gtcttcttta ggattggtga agaggtcttc   317760
tggtttacct tcttcagcga tcacgccctt atccataaag ataacacggt gagagacatc   317820
acgggcaaat tccatttcat gggttacgac aatcatggtc aagccttcct gagccaggtc   317880
ctgcatgatt ttgaggactt ctccaaccat ttctggatcg agagctgatg ttggttcatc   317940
aaagagaata gcgtccggat tcatggagag ggcacgagcg atggccacac gttgtttttg   318000
accacctgag agttgttttg gtttggcttg ccagtagcgt tctcccatgc cgaccttttc   318060
caggttttct ttggcaatct tttcagcttc tgtgcgttcg cgttttagga cagttgtctg   318120
agcgacgatt gtgttttcaa gaacattgag attttcaaag aggttaaagg attggaaaac   318180
catccccaac ttttcacggt attgcgtgag gtcatagcct ttttcgagga cgttttgtcc   318240
atgataaagg atttgtccat cagttggtgt ttcaagtagg ttaatggagc gtaggaaggt   318300
cgattttccg cttccagagc ttccgatgat agagatgacc tctcccttgt ggacagtgag   318360
tgaaatgtct tttagcactt cgttttgtcc ataggatttt ttgaggtgtt taatttcaag   318420
gattgcttgt gtcattattt caaatcctcc gtttgcattt ggttagcacc tgtagtgtag   318480
gtatccatgt ccattctgcg ctcgataaag cgtaggatac gtgttacggt gaaggtgagg   318540
acaaagtaaa tcacggcgat gattgtaaat gtctggaagt attgataggt ttgtgttgcc   318600
acggtatttc ctgagaaata aagttcgaca acagagataa cgttcaatac agatgtatct   318660
ttgatattga tgacaaattc attaccagtt gcaggtagga tgttacggac tacctgaggt   318720
aggacaatct tacgcatggt ctggttatgg gtcataccaa gagcagtcgc agcttcaaat   318780
tgtcccttgt caactgctag gataccacca cggacgattt cagtcatgta ggcaccggta   318840
ttgattgaaa cgatgaagat agcagccagt gtacggtcaa ggttgatccc gaaagcttgg   318900
gcagttccat agtagataac catcgattga acaatcattg gcgtaccacg gaaaatttca   318960
atgtagacat tgagaaccca gccgactagt ttttgtaggc cgtaaatgac tttgttttca   319020
gagagaggag cagtacggaa gacaccaatg gcaagtccaa taatgagacc tatgatggtt   319080
ccgacgatag agattaaaag agtgatacca gcaccacgca agagttgttg ccagttttca   319140
gaaagaattt tagcaacttg gctaaagaaa ctactgctag tctcttcagt tgttgtagct   319200
tcggcaggtt gttccttgat catacgatcc atcaaggcaa cttggtcatc ttttgaaatg   319260
gtttcaatgc tggcattgat ttggctaata cgattgtcat ttttacgaag cccgatagcg   319320
atagctgtat cttcttcccc agttttgaaa ccaggttcta cttgaatcat cttgaactta   319380
gagttcgcag cttcagcagt cagtgcttct ggacgttcag aaacataagc atcaatgaca   319440
ccagcctcaa gagcttgtcg catttgagcg aagtctccca tggctgtttc ttttttagca   319500
cctgggattt gtgcaatcaa gttataaagg tagacccctt gttgagaagt gatttttgca   319560
ccgttaaagt catccaaaga tttagcactt gcgtaggcag aatctttttt gacaagcaaa   319620
actggttcgc tagtatagta actgctcgaa aaggcaattt cttgtttgcg ttctgcagtt   319680
ggactcatac ctgcgataat catgtcaatc ttaccagaag taagggcagg gactagacct   319740
tcccacttgg ttttaacaac caaaggttct ttacctaagt ccttagcgat tttcttggcg   319800
atttgaacat cgtatccgtt ggcatactga ttggtcccat cgattttgac agctccgttg   319860
ctatcatcat cctgggtcca gttaaaggga gcatatgctg cttccatacc gatgcgtaaa   319920
tattcatcgg cttgagcaac attgacaagt cctagcatca gcaagagact tgtgaaaata   319980
gataagtata tttttctcat gatttctcct attctgatct attaaaaaat aactgtctcc   320040
tattttatcg aaaaatgcgt aatttttcaa cataagtaag tctttactta cgaaaaaatg   320100
ctataatgat aagaaagata aaaagggggc ttagttgatg aaaaaaactt ttttcttact   320160
ggtgttaggc ttgttttgcc ttcttccact ctctgttttt gccattgatt tcaagataaa   320220
ctcttatcaa ggggatttgt atattcatgc agacaatacg gcagagttta gacagaagat   320280
agtttaccag tttgaggagg actttaaggg ccaaatcgtg ggacttggac gtgctggtaa   320340
gatgcctagc gggtttgaca ttgaccctca tccaaagatt caggccgcga aaaacggtgc   320400
agaactagca gatgtgacta gcgaagtaac agaagaagcg gatggttata ctgtgagagt   320460
ctataatcca ggtcaggagg gcgacatagt tgaagttgac ctcgtctgga acttaaaaaa   320520
tttacttttc ctttatgatg atatcgctga attaaattgg caacctctga cagatagttc   320580
agagtctatt gaaaagtttg aatttcatgt aaggggagac aagggggctg aaaaactctt   320640
tttccataca gggaaacttt ttagagaggg aacgattgaa aagagtaacc ttgattatac   320700
tatccgttta gacaatcttc cggctaagcg tggagttgag ttgcatgcct attggcctcg   320760
gaccgatttt gctagcgcta gggatcaggg attgaaaggg aatcgtttag aagagtttaa   320820
taagatagaa gactcgattg ttagagaaaa agatcagagt aaacaactcg ttacttgggt   320880
cctcccttcg atcctttcca tctccttgtt attgagtgtc tgcttctatt ttatttatag   320940
aagaaagacc actccttcag tcaaatatgc caaaaatcat cgtctctatg aaccaccaat   321000
ggaattagag cctatggttt tatcagaagc agtctactcg acctccttgg aggaagtgag   321060
tcccttggtc aagggagctg gaaaattcac ctttgatcaa cttattcaag ctaccttgct   321120
agatgtgata gaccgtggga atgtctctat catttcagaa ggagatgcag ttggtttgag   321180
gctagtaaaa gaagatggtt tgtcaagctt tgagaaagac tgcctaaatc tagctttttc   321240
aggtaaaaaa gaagaaactc tttccaattt gtttgcggat tacaaggtat ctgatagtct   321300
ttatcgtaga gccaaagttt ctgatgaaaa acggattcaa gcaagagggc ttcaactcaa   321360
atcttctttt gaagaggtat tgaaccagat gcaagaagga gtgagaaaac gagtttcctt   321420
ctgggggctc ccagattatt atcgtccttt aactggtggg gaaaaggcct tgcaagtggg   321480
tatgggtgcc ttgactatcc tgcccctatt tatcggattt ggtttgttct tgtacagttt   321540
agacgttcat ggctatcttt acctcccttt gccaatactt ggttttctag ggttagtttt   321600
gtctgttttc tattattgga agcttcgact agataatcgt gatggtgttc taaatgaagc   321660
gggagctgag gtctactatc tctggaccag ttttgaaaat atgttgcgtg agattgcacg   321720
attggatcag gctgaactgg aaagtattgt ggtctggaat cgcctcttgg tctatgcgac   321780
cttatttggc tatgcggaca aggttagtca tttgatgaag gttcatcaga ttcaagtgga   321840
aaatccagat atcaatctct atgtagctta tggctggcac agtacgtttt atcattcaac   321900
agcacaaatg agccattatg ctagtgtcgc aaatacagca agcacctact ctgtatcttc   321960
tggaagtgga agttctggtg gtggcttctc tggaggcgga ggtggcggca gtatcggtgc   322020
cttttaaaga gagctaccat agactgaaaa agtatgatat aatggaagat agaaaaaaga   322080
caaactataa gaaaagtcaa tagttttatc taaactattt cttatttcaa tttgatgatt   322140
tggcgatgat tttagagcac ggcaaaaagc ccttgaaaaa gtccattttt tcaaaggtaa   322200
tcctgtgtta atttcagaaa ttacatcact ttttgttcgt caaatggcag ctctttttta   322260
ggatataaaa cagggttcgg ataagttttt ttgcaaggtg gatgatggct acattgtaat   322320
gttttcctta ttctaactta gtcttaagat aggccttaga agcaggtgaa aagcgagggc   322380
atgctttggc agcttgtatg agtgcccacc gcagatgagg ggaaccccgt ttgaccattc   322440
ttccagctaa atcaatctga cctgactgat aaatagaaga atccagtcca gcgaaagctt   322500
gtaattgagc aggattatca aaggcatgaa tatttcgaat ctcggctaaa atgaccgccc   322560
taaacgatcc ccaatcccag taaccgtcgt gatgaccgag ttgaactcag ccatcgagtc   322620
attgatacat gtttccgcct tgtcaatgag cctcttgtaa tgcttgatga tttcgaattc   322680
acgagcagga gatgttgttc cgatagaacg aggtgcgact gagaggatat cctgaatttt   322740
agaagcggtc aatcgcttaa tttctatcag cttatcaaat cctgcctcaa tccttttctg   322800
aggattaggg tagcgtgtca agagttggta ggtatattct gaatgctttc caacgatttt   322860
atccaactca ggaaagatga tatcaagaca acgagtgtat tgtactttcc aatcagactg   322920
tttttcttga gacgatgaat atgtctagcc agtattttta ggtctacttg ccgattatcg   322980
tgttgaaatt gttcacgatt ggggtcagaa agaagtttaa gagcgatgcc atgagcgtct   323040
ttcttatccg ttttagtctt gcgaagtgat aatgatttgg caaattcctt gatgagcaaa   323100
ggattgtagg tgtaaacttt atatccttgt tcatgcagga agttcagtag attaaaggca   323160
taatgtccag tatcttcaag agcgatgaga cagtcttggt tgatctgtcg aatagacaga   323220
tctaagagtt caaaaccagc tttattattt gaaaaagtga gtggtttaag aacagttttt   323280
cctggaacat tcaaggctgt aacatcgtgt ttatttttag cgatatcaat gcctacataa   323340
agcatgggag tacctccaga tatagtattt caagtctact tggttatcca cgaatttttt   323400
gccttgttac cttagacgag atcaaacgtc tatgcgttat caaactcatt accaattgaa   323460
acaaaagctg tggttagagc ctttcggaaa tcgtcaagcg attggaggaa atgaactaat   323520
ccatagtggc ttattccaag tataccactt gggctttggc agtagctaac tgcgctaaat   323580
ataatatagg gagtaatcta tgtatcttat tgaaatttta aaatctatct tcttcggaat   323640
tgttgaagga attacggaat ggttgccgat ttccagtaca ggtcacttga ttttagcaga   323700
ggaattcatc caataccaaa atcaaaatga agcctttatg tccatgttta atgtcgtgat   323760
tcagcttggt gctattttag cagttatggt gatttatttt aacaagctca atccttttaa   323820
accgaccaag gacaaacagg aagttcgtaa gacttggaga ctatggttga aggtcttgat   323880
tgctacttta cctttacttg gtgtctttaa atttgatgat tggtttgata cccacttcca   323940
taacatggtt tcagttgctc tcatgttgat tatctacggg gttgccttca tctatttgga   324000
aaagcgcaat aaagcgcgtg ctatcgagcc aagtgtaaca gagttggaca agcttcctta   324060
tacgaccgct ttctatatcg gactcttcca agttcttgct cttttaccag ggactagccg   324120
ttcaggtgca acgattgtcg gtggtttgtt aaatggaacc agtcgttcag ttgtgacaga   324180
atttaccttc tatcttggga ttcctgttat gtttggagct agtgccttaa agattttcaa   324240
atttgtgaaa gccggagaac tcttgagctt tgggcaattg tttttgctct tggtcgcgat   324300
gggagtagct tttgcggtca gcatggtggc tattcgcttc ttgaccagct atgtgaaaaa   324360
acacgacttc accctttttg gtaaataccg tatcgtgctt ggtagtgttt tgctacttta   324420
cagttttgtc cgtttatttg tataagaaaa accttgaagg ggcaactctt caaggtttta   324480
tactcttcga aaatctcttc aaaccgcgtc agctttatct gcaacctcaa aacagtgttt   324540
tgagcagcct gcggctagcc tcctagtttg ctctttgatt ttcattgagc tttaaaatcc   324600
agtcatggta atccccaata ggcggacacc tctttctttc ttgcttaatt cttcatagag   324660
ttgcagggct atttggctta tctgactagc atcttgtgtt ttttgagcaa gactttttcg   324720
tttggtaaga gttgaaaagt cctcgtagcg gattttcaaa atgacaattt ttccagcttt   324780
ttcttgttga tgtagattga gagcgacttt ttctgataga agagtcagct cttttttgat   324840
atcttcctca gcaaggagaa tcttcccgta ggttttctcc ttgccgattg atttacggat   324900
gcgattggat ttgactggag agttgtgaat gccacgagcc tttcgataca gatcatagcc   324960
tagtctacca aaacggtcta ttagggttac ctcaggaact tcaagtaaat cagcaccagt   325020
aaaaacgccc atttgatgaa gacgttctac tgtctttttt cctactccat gaaatttgga   325080
aatatccatt tgtttgagaa aatcctcagc ctgttcaggt agaatcactg tcaaaccatg   325140
tggtttttga taatcactcg ccattttagc taagaatttg ttgtaagaaa cgcctgcgga   325200
agcagttaga tggagttctt gccagatatc tttttgaatg aggcgagcaa ttttgaccgc   325260
tgacttgata ccgagtttat tttctgtcac atccaaatag gcttcgtcaa tgctcatggg   325320
ttcaatcaaa tctgtatagc gcttaaaaat agctcgaatc tggagtccca cagacttgta   325380
tttctcataa ttccctgaga taaagacagc ctggggacaa cgttcataag cttccttgga   325440
actcatggca gaatggacac caaaagctct tgcctcataa ctacaggtag aaacgactcc   325500
ccgtccacct gtttgccgag ggtcgcttcc aataatgaca ggttttcctc tgagtttagg   325560
attatccctg atttccactg cagcaaaaaa ggcatccatg tcaatatgga tgatttttct   325620
tgacaaatca tttaacaaag gaaaaatcaa catgcctagc acctttttat actcttcgaa   325680
aatctcttca aaccacgtca gctctatctg caacctcaaa acagtgtttt gagcaatctg   325740
cggctagctt cctagtttgc ttttcgattt ccattgagtg ttactgctta ttttctttta   325800
ttataccctt ttttctgaaa aaaagaaaaa aggactttat tttttcaaaa atataataca   325860
gtttgaaata aaatatagac tgttttagaa aagaaagtgt aaaaataggg aattttcact   325920
tgttgaaatc ggttactata tggtatactt gtcttatgaa tgtaacagat gactgttact   325980
agaaaaaaga ggacattaat atggttgtta agacagttgt tgaagcacaa gatatttttg   326040
acaaagcttg ggaaggcttc aaaggcgtag attggaaaga aaaagcaagt gtatcacgat   326100
ttgtacaagc taactacaca ccttatgatg gagacgaaag cttccttgca ggaccaacag   326160
agcgttcact tcacatcaag aaaattgtag aagaaactaa agcacactac gaagaaactc   326220
gtttcccaat ggacactcgt ccaacatcta tcgctgatat ccctgctgga tttatcgaca   326280
aagaaaatga agttatcttc ggtatccaaa acgatgaact cttcaaattg aacttcatgc   326340
caaaaggtgg tatccgtatg gctgaaacta ctttgaaaga aaatggatac gaaccagacc   326400
cagctgttca cgaaatcttc actaaatatg taacaacagt taacgacggt attttccgtg   326460
cctacacttc aaatattcgt cgcgctcgtc acgcacacac tgtaactggt cttccagatg   326520
catactcacg cggacgtatc atcggtgttt acgcacgtct tgctctttac ggtgcagact   326580
acttgatgca agaaaaagta aatgactgga atgcaatcaa agaaatcgat gaagaaacaa   326640
tccgtcttcg tgaagaagta aaccttcaat accaagcatt gcaacaagtt gttcgcctgg   326700
gtgaccttta cggggttgat gttcgcaaac cagcgatgaa cgtgaaagaa gcaatccaat   326760
gggttaacat tgctttcatg gctgtctgcc gtgtgattaa cggtgctgct acatctctag   326820
gtcgtgtacc aatcgtattg gacatctttg cagaacgtga ccttgctcgt ggtacattta   326880
ctgaatcaga aatccaagaa ttcgttgatg atttcgttat gaaacttcgt acagttaaat   326940
ttgctcgtac aaaagcttat gaccaattgt actcaggtga cccaaccttt atcacaactt   327000
ctatggctgg tatgggtaac gacggtcgtc accgtgttac taagatggac taccgtttct   327060
tgaacactct tgacaacatc ggtaactcac cagaaccaaa cttgacagtt ctttggactg   327120
acaaattgcc atacaacttc cgtcgctact gtatgcacat gagccacaaa cactcttcta   327180
tccaatacga aggtgtaaca acaatggcta aagacggata tggtgaaatg agctgtatct   327240
catgctgtgt gtctccactt gatccagaaa atgaagaaca acgccacaac atccagtact   327300
tcggtgctcg tgtaaacgtt cttaaagccc ttcttactgg tttgaatggt ggttacgacg   327360
atgttcacaa agactacaaa gtatttgata tcgaaccaat ccgtgacgaa gttcttgaat   327420
ttgaatcagt taaagcgaac tttgaaaaat ctcttgactg gttgactgac acttacgtag   327480
atgccttgaa catcatccac tacatgactg ataggtacaa ctacgaagct gttcaaatgg   327540
ccttcttgcc aactaaacaa cgtgccaaca tgggattcgg tatctgtgga tttgctaaca   327600
ctgttgatac attgtcagct atcaaatacg ctacagttaa accaatccgt gacgaagatg   327660
gctacatcta cgattacgaa acaatcggtg actacccacg ctggggtgaa gatgacccac   327720
gttcaaacga attggcagaa tggttgatcg aagcttacac aactcgtcta cgtagccaca   327780
aactatacaa agacgcagaa gctacagtat cacttttgac aatcacatct aacgttgctt   327840
actctaaaca aactggtaac tcaccagttc acaaaggtgt atacctcaac gaagatggtt   327900
ctgtgaactt gtctaaactt gaattcttct caccaggtgc taacccatct aacaaagcta   327960
aaggtggttg gttgcaaaac ttgaactcac tttctagcct tgactttagt tatgcagctg   328020
acggtatctc attgactaca caagtatcac ctcgcgctct tggtaagact cgtgatgaac   328080
aagttgataa cttggtaaca attcttgatg gttacttcga aaacggtgga caacacgtta   328140
acttgaacgt tatggacttg aacgatgttt acgaaaaaat catgtcaggc gaagacgtta   328200
tcgtacgtat ctctggatac tgtgtaaaca ctaaatacct cactccagaa caaaaaactg   328260
aattgacaca acgtgtcttc cacgaagttc tttcaatgga tgacgccttg gatgcattga   328320
gctaatcaag ttcttgaata ataaaaagga accctcggtc aaacgactga gggttttgtg   328380
cttgggatag tatgagcaat tccttcggcg caatatgcaa tgtttttggg ctctttgtca   328440
actgtagtgg gttgaaaaaa agctaagctt gagaaaggac aaatttcgtc ctttcttttt   328500
tgatgttcag ggcgataaaa atccgttttt tgaagttttc aaagttccga aaaccaaagg   328560
cattgcgctt gatgtctttg atgagtttgt tagtggcctc aagtttagcg ttagaataag   328620
gcaattcaat ggcgttagtg atgtagtttt tatagcaaat aaatgtgctc aaagtggttt   328680
taaaggtgcg gttgagatga ggtaacgtgt cttgaattaa gccccaaaac tggtcagtat   328740
tcttctcttg tagatgaaat aggagtagtt gatacaggtc atagtaatct ttaagttcag   328800
gtactagagt aaagattttc ttcagacact ccctaggagt taaggtctct ctgaaagttc   328860
tagcatagaa aggcttaaga gagagtttcc gactatcttt taggataaat ttccagtaat   328920
atttaagagc tctgtattcc agagatttat catcaaattg cttcatgatg ttgattctag   328980
tctgattaag agccctgctc atgtgttgga caatgtggaa acgatcgaga acaattttag   329040
cattgggaaa taatttctta atgagaggga tataacttcc agacatatca acagtgacga   329100
ctttaacttt ttttctagct tctttcgagt acttgaagaa atgatttcgg atggttgttt   329160
gacgtctgtt atcaagaatg gtcatgattt tcttagtgtt gaaatcctga gcaatgaaag   329220
ccaatttccc cttctggtag gagaattcat cccaggagag gatttcaggc aaagtggtgt   329280
aatcctcttg gaaatgaaat tgcttgagct tacgatagac ggtagaggta gaggtagagg   329340
tagagatggc taatttagaa gcgatatgtg taagagcctc tctgttgagt aggagttggg   329400
caattttctg tctcaccatt tccgagattt ggcaattttt ctgaacgaga gttgtttcag   329460
ctacagtgac tttccgacag gacttgcatt gaaatcgtct ctttttcaaa tgaatgaggc   329520
tagggaaacc accaatctcg ataaaaggga ttttagaagg cttttggaag tcgtatttga   329580
tttgttttcc tttacagtgt ttacatttag gtgggtgata atcaagtgta gcgaagactt   329640
cgatatgggt atcgtgctga atggctttat ttaaggtgat gtttttgtct tttattccga   329700
tgagtaatgt ggtatgattg atgtgttcca taagatactt tctaatgagt tgtttaggcg   329760
cttttcatta taagtcttat gggacttttt tgatactcaa aaagccctat aatctccaca   329820
gtgggattta cccactacag aaattataga gccagaaaaa acacttttgt tcactagcag   329880
aaactagaga gcagaagtgt ttttctgttc agatttaccc aaaactggga aatatgggga   329940
taagaataga gatggcttag gaagcccctt tttgtgtgta gacagtacga tgaacttata   330000
acaaatagtg agccttttta gcaatcattg cgacccgttt gtcaaaagcc tcttttcgga   330060
tatctacaat tgtctgatag atgagacgct gttggctaac atgcaaatct aaggcaatcg   330120
tcaaaaagtg atgtttccct ttgggatact gctttttaac gtaaggcagg tattctttcg   330180
ttgtaataat aatcaatggc tctgtcaaat gctcctctga aggaggagga ctaattagaa   330240
tattgtatcc tgtaacagag gcaactttgt cagtaaaatt ccgtaaaata atggacttta   330300
ttaagtttac atctgcttga ttatttaaaa tgataaaaat cgggatagca ggtagtgagg   330360
aaaagatggt ttctgtcaag tagagtgaga aaaggtacag ccgatgctgg tcgataactc   330420
cttcaatctt ctgctcagtc atccactctt gaacaattgc tttcgaaata tgatacagtg   330480
gcttgtcgct ttcaatccca taatgttcgt aataattata atagggaact agattttgta   330540
aaccaaacaa aaacgttctt gttaagaaag tcagtgctgt taaaaaagaa agagaattcg   330600
aaatgtcatt tcctaagata ttcttgaact tggatagtag atgctttcct cttgtatgct   330660
gaagaatcag ttgaatagta tgagtctttt tttcttgatt ccatttgtcc ttggaaaacg   330720
aagaattagc agaacaataa accaaaaaga tataatccag ttcttcctga gtaaaagtca   330780
tgttggcatg tggctctaag taagtttggc aatgttccat caaaatcgga tacataaaga   330840
ggttttttaa tttttcaaac tctttggact cagggaactc aagtggaaat tcccgacgtt   330900
tccaagtgag tgccactagt atgctaaaat gaacatactc gtcaggtgtg atttctaaca   330960
gttcatgact gagttgagaa ttagactgca caatcatatg tgtgacccaa tccatacttc   331020
catcattcaa atcataaatc tcaataccaa aatgaaactg gaggagtgca attaaaaaac   331080
gaatgcgata ttcaggacca actacttgat ttttcacaag gtccaaacct actgaacgta   331140
gtaacaagcc acacttttgt cgtacgcggt agcctgttgc gatggaaata tactcttttt   331200
gtgtaaattc gttaaagctt tgattacctt gtagtagaaa gaagcggagt atttttaaaa   331260
tagttgattg gttataaagc tgatggaagt aataattcgt ttgatgagaa tggtgttcga   331320
ttaattgaac ttgttgcgta tctaaattaa atgtcaactc ttcctcgaat gtttcttgta   331380
attcctgcaa aatgcttagg agacttttag attgtaatga agttaaagta gacagttcat   331440
ctagttcaat agaccgaata tccaataata tatttaaaat ggtaatttta tctgtaattc   331500
ttttttcaat gtatttgttt agcatagtta ccgaatctta gttgcatata gataatttta   331560
attattataa tacaaaagaa actaattgtc ttgtcaaaaa ggttgtggaa tttccgactt   331620
tattgataaa acagcatgta ataaaaggca ttttaaagat agtaatgagt attggtggag   331680
ttttatggct tatttttttt attagaaaat atttttttat caaatattgt cgttctataa   331740
aaaaatatgt gataaaaata tctattgtga tggaagttgt tttaatttat actaggatag   331800
ttaatagtaa tactatacta tactatattg tatacaagtg tgtcattgcc aggttgagaa   331860
gatagctata acgcactttt atacgctttt gctacgtttg ttagtgaacg gattaactca   331920
gtgagataaa ttttatcaga acataagtaa tccgtttctt cgtgtataca gattgaaagt   331980
acctatgaat catagaagga ttaacttgtt ctatgaataa tgcttaacag ggagacacac   332040
atgaaaaaag taagaaagat atttcagaag gcagttgcag gactgtgctg tatatctcag   332100
ttgacagctt tttcttcgat agttgcttta gcagaaacgc ctgaaaccag tccagcgata   332160
ggaaaagtag tgattaagga gacaggcgaa ggaggagcgc ttctaggaga tgccgtcttt   332220
gagttgaaaa acaatacgga tggcacaact gtttcgcaaa ggacagaggc gcaaacagga   332280
gaagcgatat tttcaaacat aaaacctggg acatacacct tgacagaagc ccaacctcca   332340
gttggttata aaccctctac taaacaatgg actgttgaag ttgagaagaa tggtcggacg   332400
actgtccaag gtgaacaggt agaaaatcga gaagaggctc tatctgacca gtatccacaa   332460
acagggactt atccagatgt tcaaacacct tatcagatta ttaaggtaga tggttcggaa   332520
aaaaacggac agcacaaggc gttgaatccg aatccatatg aacgtgtgat tccagaaggt   332580
acactttcaa agagaattta tcaagtgaat aatttggatg ataaccaata tggaatcgaa   332640
ttgacggtta gtgggaaaac agtgtatgaa caaaaagata agtctgtgcc gctggatgtc   332700
gttatcttgc tcgataactc aaatagtatg agtaacattc gaaacaagaa tgctcgacgt   332760
gcggaaagag ctggtgaggc gacacgttct cttattgata aaattacatc tgattcagaa   332820
aatagggtag cgcttgtgac ttatgcttcc actatctttg atgggaccga gtttacagta   332880
gaaaaagggg tagcagataa aaacggaaag cgattgaatg attctctttt ttggaattat   332940
gatcagacga gttttacaac caataccaaa gattatagtt atttaaagct gactaatgat   333000
aagaatgaca ttgtagaatt aaaaaataag gtacctaccg aggcagaaga ccatgatgga   333060
aatagattga tgtaccaatt cggtgccact tttactcaga aagctttgat gaaggcagat   333120
gagattttga cacaacaagc gagacaaaat agtcaaaaag tcattttcca tattacggat   333180
ggtgtcccaa ctatgtcgta tccgattaat tttaatcatg ctacgtttgc tccatcatat   333240
caaaatcaac taaatgcatt ttttagtaaa tctcctaata aagatggaat actattaagt   333300
gattttatta cgcaagcaac tagtggagaa catacaattg tacgcggaga tgggcaaagt   333360
taccagatgt ttacagataa gacagtttat gaaaaaggtg ctcctgcagc tttcccagtt   333420
aaacctgaaa aatattctga aatgaaggcg gctggttatg cagttatagg cgatccaatt   333480
aatggtggat atatttggct taattggaga gagagtattc tggcttatcc gtttaattct   333540
aatactgcta aaattaccaa tcatggtgac cctacaagat ggtactataa cgggaatatt   333600
gctcctgatg ggtatgatgt ctttacggta ggtattggta ttaacggaga tcctggtacg   333660
gatgaagcaa cggctactag ttttatgcaa agtatttcta gtaaacctga aaactatacc   333720
aatgttactg acacgacaaa aatattggaa cagttgaatc gttatttcca caccatcgta   333780
actgaaaaga aatcaattga gaatggtacg attacagatc cgatgggtga gttaattgat   333840
ttgcaattgg gcacagatgg aagatttgat ccagcagatt acactttaac tgcaaacgat   333900
ggtagtcgct tggagaatgg acaagctgta ggtggtccac aaaatgatgg tggtttgtta   333960
aaaaatgcaa aagtgctcta tgatacgact gagaaaagga ttcgtgtaac aggtctgtac   334020
cttggaacgg atgaaaaagt tacgttgacc tacaatgttc gtttgaatga tgagtttgta   334080
agcaataaat tttatgatac caatggtcga acaaccttac atcctaagga agtagaacag   334140
aacacagtgc gcgacttccc gattcctaag attcgtgatg tgcggaagta tccagaaatc   334200
acaatttcaa aagagaaaaa acttggtgac attgagttta ttaaggtcaa taaaaatgat   334260
aaaaaaccac tgagaggtgc ggtctttagt cttcaaaaac aacatccgga ttatccagat   334320
atttatggag ctattgatca aaatggcact tatcaaaatg tgagaacagg tgaagatggt   334380
aagttgacct ttaaaaatct gtcagatggg aaatatcgat tatttgaaaa ttctgaacca   334440
gctggttata aacccgttca aaataagcct atcgttgcct tccaaatagt aaatggagaa   334500
gtcagagatg tgacttcaat cgttccacaa gatataccag cgggttacga gtttacgaat   334560
gataagcact atattaccaa tgaacctatt cctccaaaga gagaatatcc tcgaactggt   334620
ggtatcggaa tgttgccatt ctatctgata ggttgcatga tgatgggagg agttctatta   334680
tacacacgga aacatccgta aagtgtagaa atgataatat ctatgttctg aacgatactt   334740
ttaagaagta gcactcaaga agagatttaa gtttacttgg tgaaacctgt tttattcgta   334800
agtaaactat cattgaaagg ggagatgttt tcgaaaactt gcacagaaaa aggattatta   334860
ttgtcatgtg taattcatta cattgctcac agttgatttt aagagatatg aataaggaga   334920
aatcatgaaa tcaatcaaca aatttttaac aatgcttgct gccttattac tgacagcgag   334980
tagcctgttt tcagctgcaa cagtttttgc ggctgggacg acaacaacat ctgttaccgt   335040
tcataaacta ttggcaacag atggggatat ggataaaatt gcaaatgagt tagaaacagg   335100
taactatgct ggtaataaag tgggtgttct acctgcaaat gcaaaagaaa ttgccggtgt   335160
tatgttcgtt tggacaaata ctaataatga aattattgat gaaaatggcc aaactctagg   335220
agtgaatatt gatccacaaa catttaaact ctcaggggca atgccggcaa ctgcaatgaa   335280
aaaattaaca gaagctgaag gagctaaatt taacacggca aatttaccag ctgctaagta   335340
taaaatttat gaaattcaca gtttatcaac ttatgtcggt gaagatggag caaccttaac   335400
aggttctaaa gcagttccaa ttgaaattga attaccattg aacgatgttg tggatgcgca   335460
tgtgtatcca aaaaatacag aagcaaagcc aaaaattgat aaagatttca aaggtaaagc   335520
aaatccagat acaccacgtg tagataaaga tacacctgtg aaccaccaag ttggagatgt   335580
tgtagagtac gaaattgtta caaaaattcc agcacttgct aattatgcaa cagcaaactg   335640
gagcgataga atgactgaag gtttggcatt caacaaaggt acagtgaaag taactgttga   335700
tgatgttgca cttgaagcag gtgattatgc tctaacagaa gtagcaactg gttttgattt   335760
gaaattaaca gatgctggtt tagctaaagt gaatgaccaa aacgctgaaa aaactgtgaa   335820
aatcacttat tcggcaacat tgaatgacaa agcaattgta gaagtaccag aatctaatga   335880
tgtaacattt aactatggta ataatccaga tcacgggaat actccaaagc cgaataagcc   335940
aaatgaaaac ggcgatttga cattgaccaa gacatgggtt gatgctacag gtgcaccaat   336000
tccggctgga gctgaagcaa cgttcgattt ggttaatgct cagactggta aagttgtaca   336060
aactgtaact ttgacaacag acaaaaatac agttactgtt aacggattgg ataaaaatac   336120
agaatataaa ttcgttgaac gtagtataaa agggtattca gcagattatc aagaaatcac   336180
tacagctgga gaaattgctg tcaagaactg gaaagacgaa aatccaaaac cacttgatcc   336240
aacagagcca aaagttgtta catatggtaa aaagtttgtc aaagttaatg ataaagataa   336300
tcgtttagct ggggcagaat ttgtaattgc aaatgctgat aatgctggtc aatatttagc   336360
acgtaaagca gataaagtga gtcaagaaga gaagcagttg gttgttacaa caaaggatgc   336420
tttagataga gcagttgctg cttataacgc tcttactgca caacaacaaa ctcagcaaga   336480
aaaagagaaa gttgacaaag ctcaagctgc ttataatgct gctgtgattg ctgccaacaa   336540
tgcatttgaa tgggtggcag ataaggacaa tgaaaatgtt gtgaaattag tttctgatgc   336600
acaaggtcgc tttgaaatta caggccttct tgcaggtaca tattacttag aagaaacaaa   336660
acagcctgct ggttatgcat tactaactag ccgtcagaaa tttgaagtca ctgcaacttc   336720
ttattcagcg actggacaag gcattgagta tactgctggt tcaggtaaag atgacgctac   336780
aaaagtagtc aacaaaaaaa tcactatccc acaaacgggt ggtattggta caattatctt   336840
tgctgtagcg ggggctgcga ttatgggtat tgcagtgtac gcatatgtta aaaacaacaa   336900
agatgaggat caacttgctt aagtaagaga gaaaggagcc attgatgaca atgcagaaaa   336960
tgcagaaaat gattagtcgt atcttctttg ttatggctct gtgtttttct cttgtatggg   337020
gtgcacatgc agtccaagcg caagaagatc acacgttggt cttgcaattg gagaactatc   337080
aggaggtggt tagtcaattg ccatctcgtg atggtcatcg gttgcaagta tggaagttgg   337140
atgattcgta ttcctatgat gatcgggtgc aaattgtaag agacttgcat tcgtgggatg   337200
agaataaact ttcttctttc aaaaagactt cgtttgagat gaccttcctt gagaatcaga   337260
ttgaagtatc tcatattcca aatggtcttt actatgttcg ctctattatc cagacggatg   337320
cggtttctta tccagctgaa tttctttttg aaatgacaga tcaaacggta gagcctttgg   337380
tcattgtagc gaaaaaaaca gatacaatga caacaaaggt gaagctgata aaggtggatc   337440
aagaccacaa tcgcttggag ggtgtcggct ttaaattggt atcagtagca agagatgttt   337500
ctgaaaaaga ggttcccttg attggagaat accgttacag ttcttctggt caagtaggga   337560
gaactctcta tactgataaa aatggagaga tttttgtgac aaatcttcct cttgggaact   337620
atcgtttcaa ggaggtggag ccactggcag gctatgctgt tacgacgctg gatacggatg   337680
tccagctggt agatcatcag ctggtgacga ttacggttgt caatcagaaa ttaccacgtg   337740
gcaatgttga ctttatgaag gtggatggtc ggaccaatac ctctcttcaa ggggcaatgt   337800
tcaaagtcat gaaagaagaa agcggacact atactcctgt tcttcaaaat ggtaaggaag   337860
tagttgtaac atcagggaaa gatggtcgtt tccgagtgga aggtctagag tatgggacat   337920
actatttatg ggagctccaa gctccaactg gttatgttca attaacatcg cctgtttcct   337980
ttacaatcgg gaaagatact cgtaaggaac tggtaacagt ggttaaaaat aacaagcgac   338040
cacggattga tgtgccagat acaggggaag aaaccttgta tatcttgatg cttgttgcca   338100
ttttgttgtt tggtagtggt tattatctta cgaaaaaacc aaataactga tattcaatgt   338160
acatcattat gaaaaagata gcaggctgaa gggaagacca gagtactctg aggtgatgtt   338220
aatcaggaat catggtgatg tggcatgaat cacaataacg gatatgaggc tgggcagatt   338280
gtgccagcct cattgtgggt tattgtttgt aaaacgatag gactggtctg gtaatcattt   338340
taggaatgga caggactggg attctgattt aaaatggatg gtgaatcaga aagaaatgag   338400
attttctcgt ttctcttagc agataggatt gtctgttagg aaaagcgata aaatgatgag   338460
tttgaagata aagggatgct gataaaaatg gtaaaaacaa aaaagcaaaa acgaaataat   338520
ctcctattag gagtggtatt tttcattgga atggcggtaa tggcgtatcc gctggtgtct   338580
cgcttgtatt atcgagtgga atcaaatcaa caaattgctg actttgataa ggaaaaagca   338640
acgttggatg aggctgacat tgatgaacga atgaaattgg cacaagcctt caatgactct   338700
ttgaataatg tagtgagtgg cgatccttgg tcggaagaaa tgaagaaaaa agggcgagca   338760
gagtatgcac gtatgttaga aatccatgag cggatggggc atgtggaaat ccccgttatt   338820
gacgtggatt tgccggttta tgctggtact gctgaagagg tattgcagca aggggctggg   338880
catctagagg gaacttctct gccgatcgga ggcaattcga cccatgcggt gattacggca   338940
catacaggtt tgccaacagc taagatgttt acggatttga ccaaacttaa agttggggat   339000
aagttttatg tgcacaatat caaggaagtg atggcctatc aagtggatca agtaaaggtg   339060
attgagccga cgaactttga tgatttattg attgtaccag gtcatgatta tgtgaccttg   339120
ctgacttgta cgccatacat gatcaatacc catcgtctat tggttcgggg gcatcggata   339180
ccgtacgtag cagaggttga ggaagaattt attgcagcaa acaaactcag tcatctctat   339240
cgctacctgt tttatgtggc agttggtttg attgtgattc ttttatggat tattcgacgc   339300
ttgcgcaaga agaaaaaaca accggaaaag gctttgaagg cgctgaaagc agcaaggaag   339360
gaagtgaagg tggaggatgg acaacagtag acgttcacga aaaaaaggca caaaaaagaa   339420
gaaacatccg ctgatccttc ttctgatttt cttagtagga ttcgccgttg cgatatatcc   339480
attggtgtct cgttattatt atcgtattga gtcaaacgag gttattaaag agtttgatga   339540
gacggtttcc cagatggata aggcagaact tgaggagcgt tggcgcttgg ctcaagcctt   339600
caatgcgacc ttgaaaccat ctgaaattct tgatcctttt acagagcaag agaaaaagaa   339660
aggcgtctca gaatatgcca atatgctaaa ggtccatgag cggattggct atgtggaaat   339720
tcctgcgatt gatcaggaaa ttccgatgta tgtcggaacg agtgaggaca ttcttcagaa   339780
aggggcaggg ctgttagaag gggcttcgct gcctgttgga ggtgaaaata cccatacagt   339840
gatcactgct cacagaggat tgccaacggc agaattgttc agtcaattgg ataagatgaa   339900
aaaaggggat atcttttatc ttcacgtttt agatcaggtg ttggcctacc aagtggatca   339960
gatagtgacg gtggagccga atgactttga gcctgtcttg attcaacatg gggaagatta   340020
tgcgaccttg ttgacttgta caccgtatat gattaacagt catcgtctgt tggtacgtgg   340080
gaagcggatt ccgtatacgg caccaattgc agagcggaat cgagcggtga gagagcgtgg   340140
gcaattctgg ttgtggttat tactaggagc gatggcggtc atccttctct tgctgtatcg   340200
cgtgtatcgt aatcgacgga ttgtcaaagg actagaaaag caattggagg ggcgtcatgt   340260
caaggactaa actacgagcc ttattgggat acttgttgat gttggtagcc tgtttgattc   340320
ctatttattg ttttggacag atggtgttgc agtctcttgg acaggtgaaa ggtcatgcta   340380
catttgtgaa atccatgaca actgaaatgt accaagaaca acagaaccat tctctcgcct   340440
acaatcaacg cttggcttcg caaaatcgca ttgtagatcc ttttttggcg gagggatatg   340500
aggtcaatta ccaagtgtct gacgaccctg atgcagtcta tggttacttg tctattccaa   340560
gtttggaaat catggagccg gtttatttgg gagcagatta tcatcattta gggatgggct   340620
tggctcatgt ggatggtaca ccgctgcctc tggatggtac agggattcgc tcagtgattg   340680
ctgggcaccg tgcagagcca agccatgtct ttttccgcca tttggatcag ctaaaagttg   340740
gagatgctct ttattatgat aatggccagg aaattgtaga atatcagatg atggacacag   340800
agattatttt accgtcggaa tgggaaaaat tagaatcggt tagctctaaa aatatcatga   340860
ccttgataac ctgcgatccg attcctacct ttaataaacg cttattagtg aattttgaac   340920
gagtcgctgt ttatcaaaaa tcagatccac aaacagctgc agttgcgagg gttgctttta   340980
cgaaagaagg acaatctgta tcgcgtgttg caacctctca atggttgtac cgtgggctag   341040
tggtactggc atttctggga atcctgtttg ttttgtggaa gctagcacgt ttactacgag   341100
ggaaataaaa agaaatgaaa ggaaagctaa ggctgttcct ttttccggct ctttgtcaac   341160
tgtagtgggt tgaaaaaaag ctaagctcga gaaaggacaa attttgtcct ttcttttttg   341220
atattcagag cgataaaaat ccgttttttg aagttttcaa agtttcgaaa accaaaggca   341280
ttgcgcttga taagtttgat gagattattg gtcgcttcca gtttggcatt agaatagtgt   341340
agttgaaggg cgttgataac cttttcttta tctttgagga aggttttaaa gacagtctga   341400
aaaataggat gaacctgctt aagattgtcc tcgataagtt cgaaaaattt ctccggttcc   341460
ttattctgaa agtgaaacag caagagttga tagagctgat agtgatgttt caagtcttgt   341520
gaatagctca aaagcttgtc taaaatctct ttattggtta aatgcatacg aaaagtaggg   341580
cgataaaaat gtttatcgct gagtttacgg ctatcctgtt gaatgagttt ccagtagcgc   341640
ttgatagcct tgtattcatg ggattttcga tgaaactgat tcatgatttg gacacgcaca   341700
cgactcatag cacggctaag atgttgtaca atgtgaaagc gatcaagaac gattttagca   341760
cacgggaaaa gttgtctagc taagtcatag taaggactaa acatatccat agtaataatt   341820
ttgacgcgac atcggacggc tctatcatat ttaagaaagt gatctcggat gacagcttgt   341880
gttctacctt caagaacagt gatgatatcg agcttttcaa aatcttgcgc aataaagctc   341940
atctccatct cccgattgaa acagtcactc cccggactgt ttcaacgtcc caggacataa   342000
tctcaggaag acgcgaaaaa tcatgctcaa agtgagaatc attgagcttg cgaatgacag   342060
ttgaagttga aatggccagc tgatgagcaa tatcggtcat agaaatcttc tcaatcaact   342120
tttgcgcaat tttttggttg ataatacgag gaatttgatg attcttcttg acgatagaag   342180
tttcagcgac catcattttt gaacagtgat agcacttgaa acggcgtttt ctaaggagaa   342240
ttctagaagg cataccagtt gtttcgaggt aagggatctt agacggtttt tgaaagtcat   342300
atttcttcaa ttggtttccg cactcagggc aagatggggc gtcgtagtcc agtttggcga   342360
tgatttcctt gtgtgtatcc ttattgatga tgtctaaaat ctggatatta gggtctttaa   342420
tgtctagtaa ttttgtgata aaatgtaatt gttccatatg attctttcta atgagttgtt   342480
ttgtcgcttt tcattatagg tcatatggga ctttttttct acacaaaaat aggctccata   342540
atatccatag gggatttacc cactacaaat attatagagc cataaaagca tcaacatctt   342600
gtgtggcacg taaaccatga tattctaaga cataaccacc gacacagata attgttaaag   342660
tcagattttc ctgaattaat tccttattta gggcttggaa gaccggtttc attttatcca   342720
tgtttgtatt tctccatcaa tttttgaaca ttggttaact tagcaggttt atttaatgaa   342780
atcacatatt tatgagttgg agtatgctct tgaaaggcat acttcaagct aattttttga   342840
aaacgggtta gttctttgga gtctagcaac ttttctacat cttggtttgt taaataagaa   342900
tagtcttcaa aaataacttt tcgcaaatag cgaaaccaat ggcttgcgtt gaattgtgat   342960
tgtttggatg cctgtatcat ataatcgtac caatccattg tcttcctcct ataaaattta   343020
gtttatatta ttgtagttta tattcaaaaa tgtagttttt cttaattagc tcgtatctat   343080
aggatgatac tgaaaatctt cttgttgctt taaatcacaa tcgaaaaatt ctgtttttca   343140
tcttagaaaa gaatgtttag aaatgtaaaa tgaacctttt ttcttatccg aaaaccttac   343200
taaagtatat aatttaggaa gtcaatcctg tatgataatg tttgtactat cgtcgagttt   343260
ttgcttgatt gcctaacgag ataaatttta gaagaatttt cggtgtgatt tgacaagctt   343320
ctgactggaa ggatagttac actagtattg tttattaaaa tgagcagata gagaaaattt   343380
ggaatctatt tgcttattat caatcgtttt tttagcttat ttgtcttaga ttggtataga   343440
actgagctat ggattaatac tcttgtatct tatcctgttc ctaaatatgt tggtagaaaa   343500
atgaagcagt tgttacgagt gtctgtattg gaaaaaattt tgtctataga attctttaaa   343560
tgatatgaag gctaggaatg ccaaagcact gacatatttc gtttgaatct catccgctct   343620
ctttacttgt atttgtagaa atgctatcag taatatattc gcgaacacta tgatttacaa   343680
cagtgtggtc gtacatcttt gtaactttat tatacaacaa ccatttacag gtgtaaagtt   343740
gagcagtgtc tttagtaaat ttagggattt gttttgtcat agttttgata cctgtattcg   343800
ttgtttcatg agcatttgac gtttcttttc atgtaggcat ttcaacaatt agaatgatat   343860
ttttccgagg atgaacttat atattgtgac tttttagagt tatgatgcct cttgatttga   343920
ctatcgctat caatttcatc cacttttaca gtttcatggt tttatgaacc gaaacatcta   343980
ggtacaggtt ttagcatcaa ttgattgttt ttgagccata tgaagttgaa acgtggagat   344040
gcttttcttg tgataacgcc ctattcaaag aggaataacc gtttttggag agagttcagt   344100
actatgtggc gctaaatact atatgtaaaa catatattaa acaagattta actaaggaga   344160
attgtaaaaa caaaaatgag aatttcatat aaagtttatt ctaggagtat gtatcttgaa   344220
taaaaattgt tatttaagtt ctgggggtta tgatgaatgt ttttataata ataaaatgca   344280
gctagaagaa aagttatttt aatataaatc actcaacata gcgagaaggc ggtttcctat   344340
atggaagtcg tcttgttttc atattgtcta aatacgagat atctactaca ggttatagtt   344400
gatttaaaca ggtctataga tttctaatat attaaggtga aataatatct tgtaatacat   344460
tgctatgttc tatgaaaaaa gcgacgatag ctaatgcaca agctcctata cttccacgat   344520
gtttgttgta aggtaaaatt tcaatttcta tattacgagt aaagggaacg aagtggagct   344580
ggtcttggat tttatccctg acttcatgag tgaaaggttg ataattaagc aattgactgt   344640
tgatatagat tttatcagca ggattgatga ggaggagatt tgcaatagaa gtggctaata   344700
aattgactcc tttatcaatt tgttgacgta aagcggagtc gcctaaatta taagccgtta   344760
aaagggtgtc taaatgaatg tctttttcag tctttacaag gctttttagt acagttagtt   344820
gggaattttt aaataataat tgggcgtgtt tgattaacca agcatccgaa atatatgttt   344880
gtaaacaacc tttttttccg cattcacaat attgcccatt caattcgaca atggtgtgtc   344940
caatttctcc gatataagga tttttagagg ctcctatttt ttcttttgtg aaaaaggaag   345000
tgtaaatacc taatccagcg tgtaggaaaa taaagttatc gggggtattg tgtggattaa   345060
aaaggtattg tcctatagcc atacaatcga tattattttt tacaataaaa ggaaaattga   345120
atcttttaat tacatttaat aaattaaaag attcccatat ggggttgttt gtaatgatac   345180
ttccggagtc tttgttataa tgtccaggta ttgataagcc aaatccaagt aattttgttt   345240
ccaaagggac gtactctata gctgttttta tcatattggt aatggtggaa ttgatttctg   345300
aaataggata atcttcattc aaaatttctg tctcgaaaag agttttccct tgtaagtcac   345360
atagactgag aaagatacct aggacgttta tttcaatacc tccaacaaca tacggaatat   345420
tatctgtgat agaaatagtt tttctacgtc ttccagatcc ggaaaactcg ctaaattcat   345480
caccagtttc gtatatgagg gactgttcgc ttagctcttt tatgatgtta gtcgttgttg   345540
ctggagtaag tcctgtttca ttaacaatat ctgtacggga tgttgctgga tttcgatata   345600
gaaactccag tatagtggct ctattttgta aaaaggctga ttgttttgta atcatttgtt   345660
tcctcctttg gtttatttta tattaaacat aagaaaaaat caattaaaat tattattcta   345720
tacaaagaaa aaaatattgt aaaaacaaca aaaaatatat tgacaacgct ttctgttagt   345780
ggtatattta atttataaaa aataaaaaaa ggagttccgg tgatgaacaa tattttagcg   345840
tttttagaaa caaaagtcgc tccgtttggt gaaaaagttg gcaaccaacg gcatttgaaa   345900
gctattcgtg aaggatttat gatggcaatg cctttgattt tagtcggctc tttatttctt   345960
attctaatca gttggcctca agaggctttt acaaattggc tgaatagtgt tggattgcta   346020
agtatcttga caactatgaa tcagtcaaca gtagcgatta tctccttggt cgcttgtttc   346080
ggtattgcct acaggttgtc ggaaggatat ggtacagatg gtccgtcggc agggatcata   346140
gccttatcca gttttgtatt gatggcacct cgtttttcga gtatggttta tgataaaaat   346200
ggggagcagg tcaagcagtt atttggcggc gcaataccat tttctagcct gaatgcatct   346260
tctttgttta tggcgattac tattggattg gttacagcag agatttatcg tatgtttatc   346320
cagcgcggaa ttacgataaa aatgccaagt ggtgtcccag atgtagtaag taaatcattt   346380
tcagctcttt tatctggttt tactactttt gttttgtggg ctttggtctt aaaaggtctt   346440
gaagcggcag gagttgcagg aggtctcaac ggactcctag gtgcaattgt tggaacaccg   346500
cttaagttaa ttgcaggaac gcttccaggt atgattctat gtgttattgt aaactcattc   346560
ttttggttct gtggagttaa tgggggacaa gttttaaatg cttttgtaga cccagtttgg   346620
ttacaattta ctacagaaaa ccaagaagct gtggctgcag gacaaacact ccaacacatt   346680
attacattac cgtttaaaga tttatttgta tttattggtg gcggtggagc gactattggt   346740
cttgcgattt gtctcttcct atttagtaag agtcgtgcga ataaaacatt aggtaagcta   346800
gctattatac cgtctatttt taatatcaat acagctattc tatttacgtt tccaacagtt   346860
ttaaatccga ttatgctgat tccgtttatt gctactccta caatcaatgc cttgattacc   346920
tatgtatcaa tggctgtagg attagtaccc tatacaacag gtgtaatcct tccgtggaca   346980
atgccaccga ttataggagg cttccttgca acaggggcta gttggcgagg agctctatta   347040
caagttgttt tgattttggt ttctgtagca atttattatc cattcttcaa aattgcagat   347100
aaacgcaatc ttgaaaaaga aaaagctact gttggaggga aataagatgg ttatcagagt   347160
atttgatcaa cagaaaaata cttattctag ctttgcctta gaggaattaa gttactatat   347220
gaatcgggtc tttaagacta acatagagct tgtcgaggag aaggaagcgg atatttttgt   347280
aggattagtc aataaagagg acagaaaaga ccatgttctt atctcattag acaagggtaa   347340
ggggagaatt gagtctaata caattgtagg tttacttatt ggaatttacc gaatgtttca   347400
tgaatttggg gttgtgtata ctagaccagg gcgcagacat gactttgttc cagagttacg   347460
atttgaagat tttttagata aacagctatc tatagatgaa acagccagtt actatcatag   347520
gggagtatgt atagagggag cggattcatt tgaaaatata ctagatttca ttgattggct   347580
acctaagatt gggatgaaca gttttttcat ccagtttgaa aatccttact cttttttgaa   347640
acgttggtat gaacatgaat ttaatccata tctaaataaa gaacaatttt caaatgaatt   347700
agtacaagaa ttgagtgata ggttggataa agaattgcaa aaaagaggtc ttattcatca   347760
tcgtgttggt catggatgga caggtgaagt tttaggttac tcttcaaaat ttggctggga   347820
atcaggtctt agtatttcag aggagaagaa accctatgtc gctgaaataa acgggaaacg   347880
agaattgttt aatacggctc cgattttaac cagcctggat ttttcaaatc cagatgtagc   347940
tgataagatg gtagaaatta tcaaggatta tgccaagaaa agacctgatg ttaactactt   348000
acatgtatgg ttgtcggatg ctcgtaataa tatttgtgaa tgcgaaaact gtagacaaga   348060
attggtttcg gatcagtata ttcgtattct caatcaattg gatagggctt taacgagtga   348120
gggattagat acaaagattt gttttctgct ttatcatgag ttgttatggg cacctcagaa   348180
agaaaaatta gataatcctg aacgctttac catgatgttt gcaccgatta caagaacatt   348240
tgaaatgagt tatgcagatg tagattttga caattccata cctacgccta aaccttatat   348300
gcgtaataaa attatacttc cgaattctct tgaggaaaat ttatcttatc tttttgagtg   348360
gcaaaaagca tttaaaggag atagtttcgt atatgactat cctttagggc gtgctcatta   348420
tggcgattta ggctatatga aaattagtca aactatttac agagatgtat cttatctttc   348480
caacctacat ttgaacgggt acatttcgtg tcaagaatta cgtgccggat tccctcataa   348540
ttttcctaat tatgtcatgg gggaaatgct ctggaagaag acaagaagtt atgaagaatt   348600
gattgaagaa tacttttctg ctttgtatgg ggaaaattgg cagtctgttg ttgaatattt   348660
agaaaaatta tccatttatt cctcttgtga ttattttaat gcaattggca gccgtcaaag   348720
tgatgtttta gcgaatcatt attatatagc ttacaatcta gctgataatt ttttaccaat   348780
tattgaggaa aatatttcta agttattaaa tagtcaaaag gatgaatgga aacagctcag   348840
ttatcatcgt gaatatgttg ttaagatggc gaaggcttta tatcttcaag caactggaaa   348900
aacaaggcaa gctcaagatg aatggagaaa tgtgttgaat tatatccgtg ggcacgaatt   348960
gctatttcaa tctaatttgg atgtttatcg tgtaattgaa gtagcaaaaa attacgctgg   349020
tttccactta taaatcataa gtatagaaaa tgaactaagg tattcagaga agattgatcc   349080
taaatattat gaaatttaag gatttttaag atatttaggg tcaactttct atttatatcg   349140
tagcgaagtc attttaataa tgatgtgtaa aagatggatc aagattgagg aggaagaaag   349200
atgaaatcaa aagaagaaat aaatatgctt ggttttacaa ttgtcgctta cgcaggagat   349260
gcaaggtcag atttgatgga tgctttggcg tttgcgagag atggatattt tgaacaggca   349320
agagaattgg ttgagtctgc aaacgactca atagtgtctg cccatcgaga acagactaat   349380
ttattagcgg aggaggcata tggagataat tttgaagtga gctttattat gattcatggt   349440
caagatactt tgatgacaac gatgctattg tatgatcagg taaagttttt tattgatgaa   349500
tatgaacgaa ttcgaaagat tgaagaacat attggtttgc aatgaggatt agtcatggaa   349560
aatttacagg ttaaagcctt accgaaggag tttttattag gaactgctac cgctgcttat   349620
caagtagagg gtgcaactag ggtagatggc aaaggaataa atatgtggga tgtttatttg   349680
caagaaaata gtccgttctt accagatcca gctagtgatt tttattatcg ttacgaagag   349740
gatatagctt tggcggcaga acatggtttg caggctttgc gtttatctat ttcttgggtt   349800
cgtatatttc ctgatataga tggggatgct aatgtattag ctgttcatta ttaccataga   349860
gtttttcagt cttgcttaaa acataatgtg attccgtttg tttctttaca tcattttgat   349920
tcgcctcaga aaatgttaga aacaggggat tggttgaaca gagagaatat tgatcgtttc   349980
atacgatatg ctcgcttttg tttccaagaa tttacagaag tcaagcattg gtttacaatc   350040
aatgaactga tgtctcttgc tgcaggtcaa tatataggag gtcagtttcc tccaaatcat   350100
cattttcaat tatctgaagc aattcaagcg aatcataata tgttgttggc gcatgctctt   350160
gcagtcctcg aatttcatca attagggatt gagggaaagg taggttgtat tcatgcttta   350220
aagccaggct atcctattga tgggcaaaaa gaaaatattt tggcagctaa acggtatgat   350280
gtttataata ataaatttct attagatgga acttttttgg gctactacag tgaggacacg   350340
ctttttcact tgaatcaaat attggaagct aataattcta gctttattat tgaagatggt   350400
gatttagaaa ttatgaagag agctgcacct cttaatacga tgtttgggat gaattattat   350460
cgttcagaat ttattcgtga atacaaaggt gaaaatagac aagaatttaa ttcaacagga   350520
ataaaaggac agtcttcttt taaattaaat gctctaggtg aatttgtaaa aaaacctggt   350580
attccgacaa cagattggga ttggaatatt tatcctcaag ggttatttga tatgttgctt   350640
cgtatcaaag aagaatatcc tcaacatccg gtcatttatt taactgaaaa tggtacagcc   350700
cttaaagaag ttaagccaga gggcgagaat gatattattg atgacagtaa gagaatccgt   350760
tatattgagc aacatttaca caaagtttta gaggctcgag atagaggagt caatattcaa   350820
ggctatttta tatggtcttt gcaagatcaa ttttcttggg cgaatggcta caataagcga   350880
tatggtcttt tctttgttga ttatgaaaca cagaagagat atattaagaa aagtgctctt   350940
tgggtaaaag ggctaaaacg gaattaaggt tagcgatttg actgatgttt aatatgtttt   351000
aaatatgagg ttgaattttt tataggagga gttttatgga taagctagtc gctgccattg   351060
aaaagcaaca agggaaattt gaaaaaattt ctactaataa ctatatgatg gctattaaag   351120
atggattcat tgctactatg cctttaatta tgttttcaag ctttttgatg attattatta   351180
tgattcctaa aaatttcgga gtagagttac cgagtccagc tattgtctgg atgagaaaag   351240
tgtatatgtt aaccatggga gttttgggta ttattgtttc agggactgtt ggaaagtcat   351300
tagttggaaa tgttaacaga aaaatgcctc acggaaaggt aataaatgat atttctgcaa   351360
tgttggcagc catatgtagt tatctggtat taactgtaac gcttgtagtt gatgagaaga   351420
cgggatctac aagtttgtcg acaaactatt taggatctca aggattgata acttcgtttg   351480
tcagtgcctt tattactgta aatgtttacc gattctgtat taagcgagac attactattc   351540
atttacctaa ggaagttcct ggggctatat cacaagcttt tagagatatt ttcccttttt   351600
cttttgtttt acttattagt ggtttgttag atattgtatc tcggtttagt ttagatgttc   351660
cttttgccca agtatttcaa caactattga ctcctatttt taagggggca gaatcatatc   351720
ctgctatgat gttgatttgg tttatgtgtg ctttgctttg gtttgttgga attcatggac   351780
catctattgt cttacctgct gttacagctt tgcaactgag caatatggaa gagaatgctc   351840
aacttcttgc aaatgggcag ttcccttatc attctttaac acctaatttc gggaattata   351900
tcgctgctat tggaggaacg ggggctacct ttgttgtacc atttattttg attttcttta   351960
tgcggtctaa acaattaaaa tcggtaggta aagctacaat tactcctgtt ttatttgcgg   352020
taaatgaacc tcttctattt ggtatgcctg ttattttgaa tccctatctt tttgtccctt   352080
ttttgatgac tccaccagtg aatgtatttc taggaaaggt ctttattgat ttctttggaa   352140
tgaatggatt ttatatccag ttaccttgga cctttcctgg tcccttggga ttgttaattg   352200
gaacgaattt tcaacttatc tcctttgtat ttttatcttt gattttagtt gtcgacatat   352260
tgatttattt gccattctgt agagcgtatg atagacagtt actggtgaaa gaagatattg   352320
caagctcaaa tgatattatt ttagaggagg atacaagtga aataattcct ggtgagatag   352380
atgaaataaa aagtaaggag ttgaaagtac tggttctttg tgcagggtct ggaacaagtg   352440
cgcaattagc caatgcaatt aacgaggggg ctaacttaac agaggttaga gtgattgcga   352500
attcaggagc gtacggagct cattatgata ttatgggtgt ttatgattta attattctgg   352560
ccccacaagt tcggagttat tatagagaga tgaaggtgga tgcagaaaga ttaggtattc   352620
agatagttgc taccagagga atggaatata ttcatttaac aaagagtcca agtaaagcct   352680
tacaatttgt attggagcat taccaagctg tgtagtaagt ttttccatct tttatttgag   352740
taaagatttt gtttacagat aggcttggat ttaaaaacgt tccccctttt ttaatataag   352800
aatccctctt tcacaattgt aaaaagaggg attttgtatt ttatctctta gaccaagttc   352860
tcttcataaa gagaaggagg attgggtaaa tctccaagcg ccctgcaatc attgcaaagg   352920
ataggagaat ttttgagatg ggactaaaga ttgagaaact agaagtggtt cctagaatag   352980
gcccgatatt attgaaacag ctaaagacag cgctggtcac gaccagaaaa tcattgctat   353040
ctaggctgac aataaagata agcgctagca aaatcatagc atagatgaca aagtacttga   353100
gaatcttatg ctgggtatct ttgtcaatca ccgttttatt aacatggagg gtcaaaacac   353160
ggtggggcga taggattgac aaaatttggt ttttggcaat ttttgaaagg atgaggcctc   353220
gaataatctt gagtccacct gcagttgatc cagcagagcc accgattgcc atgaggaaaa   353280
ggaggataaa ctgggagaag aggggccagt tggtaatatc tccatatcca aaaccagttg   353340
ttgtaatgat gttggaaacc tggaagaagg tcatttcaaa gctctttgaa aaccctgggt   353400
agaggtagag ggtgttgagg ctaatcaagc ctgtagaaac cagtacaatg accaagtaag   353460
ccctaagctc ttcatctcca aagaaggcct tgatgcgacg gagcatgagg tagtagtaga   353520
ggttgaaatt tactccaaaa accagaactc cgatactgac cagataggta atcagtgagc   353580
tgccatagtg ggcaattccg tcgttataga cggtaaagcc tccagttccc gctgtcccca   353640
tagcaataac aaaactatcg tagagaggca taccggctag ataatagatg atgacaaaga   353700
gggagaagag agctagataa aggagataga gaatctgggc agtgtttttt agtttggata   353760
caaccttgcc aaaaacagga cctggaacct cagccttcat cacctctagg tggctatttt   353820
tggcattgtc cataatagca agtgcaaaaa caagcactcc catccctcca atcaagtggg   353880
taaaacttcg ccagaagagg agggaacggc tgagaaccga aacgtcgttc aaaatacttg   353940
ctccagtagt tgtaaatcca gaactaattt caaaaaaggc atcaataagg ctggggattt   354000
gcccagaaaa gacaaagggg agaccaccaa agaaagacca aaggatccaa cagagggcaa   354060
cgatcaagac tccctccttg gcataaatcc gttgattttt tggcttctgt aaactccctg   354120
aaccgcctaa caatacgaga atccctatgg tcgaaaagag ggctgtaaag acttggctcg   354180
attcacggta atagacagca atcgcaacag gaaccaaaag aagaacagct tcaatcaaaa   354240
gtaattttga aaggaggtaa cgaatcatac ttttattcat ttcttacctc gcgatcaagt   354300
cataaatctt ggtgatgttt ggcaacaagg ttgttactag gagcttgtct ccaacttcca   354360
acatatcctc cccagttggg aaaatagtct tgccctttcg aataatggct gcaataagaa   354420
cccctttttt caatttcagt tgagaaagag gtttggcagt cattttattg gcttccttga   354480
tatggaattg cagggtttcg atttggccat tggctagatg gtgcatagct tgaaggtctg   354540
aatactgggc attaactcga ccacgaataa agtgcataat cgtatctaca gcgatgcttt   354600
taggtgtgat gatacttgaa aaatcaggcg cattgataat ctcgaggaga ctggtacgat   354660
tgaccttagt aatatttttc tgtacaccta ccctgtcaag gaacatagat gtaatcagat   354720
tttcctcatc gactcctgtt agagtcgcaa cggcatcata gtgttgagca ctttcttcca   354780
gcaggatatc ttttgcggtt ccatctcctt gaacgatgta gagatttggg aatttctcgc   354840
taaagaagct ggcgatttca ggattgattt caatgacttt tgtatcgata cgactatctt   354900
tgagaatacc aagtagataa taggcaattc tacctgcccc aacgatgaga aggctcttca   354960
cggcgcgtga tttaaaataa ttatggaaga gtatcatatc gacacggtta ccagtgacaa   355020
agattctatc tttatcctgt acagtcatgt caccgcttgg aatgataatt tgatgatccc   355080
tctctatcgc acagacaatg acattaccaa attttttacg aaaatcagaa atgggcattt   355140
ggcaaagacc gctggtggac ttgacgacaa attccatgag gctaacgcgt ccaccagcaa   355200
agcgttcgac agacagggcg ttggggaagt caatgatatt cgcgatagcg cgggcagcca   355260
agagctcagg attaacgata agagaaaaac cgagaatatt cttttccttg aaataagagt   355320
tagaatattc agggttccgc acccgaacga tagtttcttt agctcccatt ttcttggcta   355380
gaactgctgc aatcatgttg acttcatcgt gctcagtcag ggcgataaag atatcacaat   355440
cttggacgct ggcttgctca agaatggcaa aatcggcccc gttaccaagg ataccaatga   355500
tatcaaagcg actgacaata tgattgagaa cagcttcgtc ttgctcaatc agcaaaacat   355560
catgcttttc tgcaaccaag gagcgacaga gggcaaaacc aacttttccc cctccgacaa   355620
ggataatttt cataataaaa cctacttttt catgatgtaa ctatcatacc ctttttcaag   355680
aaaaaatgca cctactagct aataacaaga gtttttagtg aaaattcgct ataaggtaaa   355740
actataccct aaccaattga aatagctatt agcgactttc tctgaaatat ggtatgataa   355800
aggatataca aggagataaa atgaataata atttactggt attacaatca gactttggtc   355860
tggttgatgg tgcggtatcg gctatgattg gagtggcttt agaagagtct ccaaccttaa   355920
aaatacatca cttgacgcac gatatcacgc cttataatat ttttgagggg agctatcgtc   355980
tctttcagac ggtggattac tggcctgagg gaacgacgtt tgtatcggtt gtcgatccag   356040
gtgtcggttc gaaacgtaag agtgtagttg ccaagactgc aaaaaatcaa tacattgtca   356100
cgccagataa tgggacgctt tcctttatca agaaacacgt tggcattgta gccattcgtg   356160
agatttctga ggtggccaat aggcgtcaaa acacagagca ttcttatacc ttccacggtc   356220
gtgatgtcta tgcctatact ggtgctaaac tggccagtgg tcacattact tttgaggaag   356280
tagggccaga gctcagtgtg gaacagattg tagagcttcc agtcgtagcg accatcatag   356340
aagatcatct ggtgaaggga gccattgata ttctggatgt gcgtttcggt tcgctttgga   356400
cctctatcac acgggaagaa ttttacaagc tggaaccaga atttggtgat cgttttgaag   356460
tgaccatcta tcatgctgat atgctggtct atcaaaatca ggttgtctat ggcaaatcat   356520
ttgcagatgt gagaattggg caacccatcc tttacatcaa ctctctctat cgtttaggtt   356580
tggctatcaa ccaaggttcc tttgccaagg cctataatgt aggtgtcggt tcatcttgga   356640
ccattgaaat aaagaaaata gaaggataaa ataggagaat agtatggaaa tcaaatttac   356700
aattaaacaa gttgttgctg tcggaattgg cgctgccctc tttgtcgtca tcgggatgat   356760
caacattcca acccctgttc caaatacaag catccagctt cagtatgcgg tacaagcgct   356820
actttctatt atttttggac cgattatcgg tttgcttgtc gggttgattg gtcatgcaat   356880
caaggactct cttgttggtt atggtctatg gtggacttgg attatcgcta gcggactctt   356940
tggtttagtt gtgggacttt ttagaaagta cgttcgcgtg atcaatggtg tttttgactg   357000
gaaagatatt cttattttta atctcattca actacttgca aatgcccttg tttggggtgt   357060
cttggcacca cttggagatg ttgtgattta tcaagaagcg gcagaaaaag tatttgcaca   357120
agggattgtt gcgggaattg ccaatggtgt atctgtagct attgcaggaa ctcttctctt   357180
acttgcctat gcaggaaccc aaactcgtgc aggaagtttg aaaaaggact aatactcaat   357240
gaaaatcaaa gagcaaacta ggaagctagc cgcaggttgc tcaaaacagt gttttgagat   357300
tgtggataga actgacgaag tcgactcaaa acatggtttt gaggttgtag atgaaactga   357360
cgaagtcagt aaccatacct acggcaaggc gaagctgacg tggtttgaag agattttcga   357420
agagtataaa atgatgggga aggctgggca actagtcttt ttcgatgttt atagattagt   357480
taggcaagta agctaggata ggaatctttt tggcgctaag attttaagag gagagactgc   357540
aagaagggct tgatttatga taaaatagaa gtctaagaag cgaatgaaga gagtaagatg   357600
aaagaagcta taattgagtg gaaggatttc tctttccggt atgaaacaca acaagaaccg   357660
accttgcaag ggatagactt gaccatttac aagggagaga aagtcttaat tgttggacca   357720
tctgggtcag gtaaatctac cttgggtcag tgtttgaatg ggattattcc caatatttac   357780
aagggtcaga catatggaga atttttgata aagggtcaag tagcctttga tatgagcatc   357840
tatgataagt ctcatctggt tagcacagtt ttgcaggata cagatgggca gtttattggc   357900
ttgtctgtgg cagaagattt ggcgtttgct ctggaaaatg atgtgacagc cctagatgag   357960
atgaaaggtc gtgtttataa atgggctgaa aagctggacc ttcttccttt actggatcag   358020
cgtcctcagg atttgtcagg tggacaaaag cagcgagtca gtctggctgg tgtcttgatt   358080
gatgaaagtc cgattctctt gtttgatgag ccactcgcca atctagatcc caagtcaggt   358140
caggatatta tcgaattgat tgaccagatt cataaggaag aggggacgac gactcttatt   358200
atcgagcacc gtttggagga cgttctgcat cgccctgtgg atcggattgt cttgataaac   358260
gatggtcgta tcctttttaa tgggagccct gaccagttgc ttgcgactga tttattgact   358320
caaaatggaa ttcgagaacc cctttatcta acgactctcc gtcaattagg tgtggactta   358380
gtcaaggaag aacaattagc gaatctggat aacttgtcta tctcaaaagg tcaggttcag   358440
ttgcagaatg aactggcaaa agaaacccca gcattgcagt cactctttag actagaggaa   358500
gtatcttttt cttatgatga tagaccgatt ttaaaatccc tacatttaga tattaaaaag   358560
ggtgaaaaga ttgctattgt cggaaaaaat ggagcaggga aatcaactct agccaaggct   358620
ataagtagct ttattcagac ggaaggacgc tatctttggg aaaaacagga tataaaaggc   358680
gattctgttg cagagcgggc ggaacgagta ggatatgtgc tacaaaatcc taatcaaatg   358740
atttcaacca atatgatttt tgatgaggtg gctctagggc tccgtttgcg aggtgtggat   358800
gagaaggaaa ttgaaacgag agtatatgaa accttgaaaa tctgtggact ttatgaattc   358860
cgtaattggc ctatttctgc cctgtcattt ggtcagaaaa aacgtgtcac cattgcttca   358920
attttggtct taggagctga aattattctc ctagatgaac cgactgcagg tcaagatcag   358980
aagaactata ctgagattat ggaatttctc gaagagttac atcaaaaagg gcataccatt   359040
gtcatgatta cccatgatat gcaattgatg ctggattatt cagaccgggt ccttgtcatg   359100
gtggatggag aattgattgc cgatactgtt ccagccagtc tgttgagcga tcctgagctg   359160
ttagtaaaag ccaatctaaa agaaacctcc atctttaact tggctaagaa actagatgtg   359220
gatccactgg atttaacggc attttacaaa gaaaggagag agggatgcaa gctaaattaa   359280
tcggttacca gcatagagat actgtgattc atcgcttgtc aggagctggg aaacttctct   359340
ttttcattct ggtatcattg gcggccatga ttagctatga taccagaatg ctcttgctga   359400
ttgccatctt ttcagtcttt ctcctctatt tatcagaaat tcgctttaaa gatgtttcct   359460
ttgtagccgt ttttgcgacg atatttgccg ttttaaacgt tttgatggtc tatctctttt   359520
ctcccgagta tggggttgga ctttatggag agagaagtgt gatttggcag ggaatcggtg   359580
tctacactct aaccagccag gagctctttt atctgctaaa tttggccatt aagtatcttt   359640
gcaccattcc tctggctatt atctttttga tgacaaccca tcctagtcag tttgcttcca   359700
gtttaaatca aattggtgtg ccctataaga ttgcttattc tgtcagcctg accttgcgct   359760
atattccaga tttgcaggaa gaattcttta ctatcaagat gtctcaggag gcgcgtggga   359820
tggaattatc caagaaagct tctcttatgc aacgaatcaa aggcaatctg ctcattatta   359880
cgcccttgat ttttagctcg ctagaacgca ttgataccat tgcgactgcc atggagttcg   359940
ccgctttggg aaagagaaaa aacgcacatg gtatagttat caggccttga aaaaaggaga   360000
ctatattacc ttgctcttgg caaccttgtt tttagtagtt agtttactac ttatcttgca   360060
gaatcaggga cgattttaca acccttggaa atagcttgaa aaaattgaaa aaatcaagtc   360120
atttctattg acaatgattc tgaaagtgtt atactaagaa agtagtttcg ctgatttact   360180
tcaaacctgt tgtgaggtaa gttaacgatg ccttaaccac gctgtttgct gagcttgact   360240
ccgggcagtg tggctatttt tttgcaatgg tgaaaggaag caagtcatga caaatcacat   360300
tgtattattt gaacctcaaa ttccacaaaa tacgggcaat atcgcgcgta cttgcgctgc   360360
gaccaattct cccctccaca tcatcaagcc tatgggcttt cctattgatg accgcaagat   360420
gaagcgggct ggattggatt actgggataa gctagagatt tatttttacg agagtttgga   360480
agatttcata tctcagatga agggaaaact ctatctgatt tcgaaattcg cggaaaaagt   360540
ctattctgag gtggatttat cgactgacga ggaccattat tttctctttg gacgtgaaga   360600
caagggctta cctgaagatt ttatgcgaga acatcctgag aaggctctcc gtattcccat   360660
gaatgatgaa catgtccgca gtctcaatgt gtctaatacc gtctgcatga ttgtctatga   360720
ggctcttcgc cagcagaact ttgcaggtct tgagctcgtc catacctatg aagtggataa   360780
attgaaataa aaaatgaaaa tgaacaaaat gcttgcgctt gcaagcgttt tttgttatga   360840
taaaagagtc ttcagggcag ggtgaaattc ccgaccggcg gtgactttaa ctaggaaatg   360900
atcttttcct tttatacttt gttgacaagc tttgcctaac cagaagttat gcctacagct   360960
tgtcgcctag tctaaaagaa aaatctctat ttccttctct ttaaagaagt ccgtgagcgc   361020
aagctgatgt ggtgagattc cacaaccgac agtatagtct ggatgggaga agacgaaaga   361080
atagccttgt ctgttttgat agatttatag ccggattgta accacttgct ttgtttttct   361140
ttaatagagt aagagggaac ttttgggata taaaaagtga gaatagatag aggaatcctt   361200
tccaacttct tctgatttta tagaaaattg gaggaacctg ttatgacaaa cacacgtcga   361260
ctttcgacca ttgcaattct atcagccatc tcatttgtgc tgatgtactt tgactttccg   361320
cttttaccag cggcatcttt cctcaagatc gaatttagta tcttgccagt ccttgtgggt   361380
ctggtggtca tggatttgcc tgctgctcta ggagtgctct tgcttcgctc actcttgaaa   361440
ttgcttctta acagccaagg agtgaatact tacattggtt tgccgatgaa tatcgtagct   361500
ttgggagttt ttgtcatcgt atttgctttg atttggaaaa aggaacggac aacccttcgt   361560
ttcctactag gctctctagc tggaactatt ggtttaacct tggccatgtt ggttctcaac   361620
tatgtttatg ctgttccttt gtacgctaag tttgctaact ttgatattgg aaaaattttg   361680
ggactttcca actacctaat gaccatggta ttacctttta acttgattga aggtgttatc   361740
ttttccgttt cattctggtt gttgtatgtt ctcttgaaac caaccttaaa acattatgag   361800
agataaacaa acatttttaa tgaagggcag ttttgccctt ttacttttcg ttattcttgg   361860
ctacatggtc aaattttacc ctgaaatgtt ggtcaatttt gaccaatcga ttcagactgc   361920
cattcgagga gacttaccag attatttgac tattcttttt cgagccctca cacgtctgat   361980
tgatatccca gtgattatca cttgggttgt cattacagct tttgtctttt atcgtaagcg   362040
atggaagata gaaagtttct tcatgctggg aaatctggct ttggcaggtc ttttaatcgt   362100
gacctttaaa aatatctacc agcgcccacg accagctatt ttacatctgg tggaggagaa   362160
gggattttcc ttcccaagtg ggcattctct agctgtaacg ctgatggtag ggactttgat   362220
tgttattctt agtcagcgga ttaaagatca ggtctggaga aaaatcgtac aaatcgtcct   362280
tggcctctac ctagtcagtg tgctggtatc aagagtctat ctgggagttc attacccatc   362340
agacgtcctt gccagtctct gtgtgggctt gggagtcctg tttatcgagt ttccctttta   362400
tgacaagctc cgcttccaat ggcgatttaa aggcaaacag aagtgagtat cgaattccct   362460
tgaggagaaa gaaatgaaag tcaatatagc agatcttcat ctgactcaac tatatttatc   362520
agaaaagaag ttgcaagata ttcagatgct ttaccagtcg gcagaaacaa tccaagtcga   362580
tccaatcagt attcttgcct ttggagattg tttgctgatt acagatgggc atcacagggc   362640
ttatcaggct ttattggcag gtcgggatac gatttctgct gagtgggata gagatggtgg   362700
tgatgaacta tatcatctct atgcgcaagc ttgcgaggaa agaaagattt actctgtttt   362760
tgatttagaa gatcgtatcc tagctcaaga tgggtatgaa gcaaaatggt ataactggtg   362820
tgatggtttt aatcaagcag caactctttt gttgaaaagg tagtgcattg tgttttgttc   362880
cttattataa ggtcaatcat tgtgaggaag cttttgcttg gtatcaggat gtgaacttgg   362940
tttacctcgt agatggggtg aagcttcctt acagtcaagc cgaccttgga agccatgtat   363000
tcctatttgg atcggcatgg tgagcttttt tggattgaag tcaaggagaa gggagaatgg   363060
tttccaattg gggatattac actatctcag gataatctcc ccattgtgat tgggaattcc   363120
gcttaccaac atcgaggact tggaaaaaag attctaagtg ctttgattga attggctcga   363180
gtaaaaggat ggaaagaatt gagagtcaag aaaatctaca cctacaatca tgcttctagg   363240
aggtgtttca agtcgcttgg atttgtggaa aatggagcaa cagaaaaagg aatgagtttt   363300
atattggaat tagtctaatc ctgccacttt ctccccctta acctttgact attccgcaaa   363360
attatcgtaa aataaagagt aaatgataaa atgaggtcag agtctgttcg ctctggcgat   363420
agtagtataa atgaggagaa acgctttgga attagaagta tttgctgggc aagaaaaaag   363480
tgaactatct atgattgagg tagcgcgtgc tatcttggaa cttcgtggtc gcgatcatga   363540
gatgcatttt agcgatcttg taaacgaaat tcaaaactac cttggaacat caaacagcga   363600
tatccgcgaa gctttgcctt tgttctacac agagttgaac tttgacggta gcttcatctc   363660
acttggggac aacaaatggg gtcttcgttc atggtatggt gtggacgaaa tcgacgaaga   363720
aatcatcgct cttgaagaaa atgacgacga tgaagtagca ccaaaagcta agaaaaaacg   363780
tgtcaatgcc tttatggatg gtgattcaga tgccattgac tacaatgcag atgatccaga   363840
agacgaagat gcatacgaag cagatccagc tctttcatac gatgatgaaa atccagatga   363900
tgaaaaaaat gaagtggaag cttatgatgc agaaatcaac gaaatcgctc cagatgactt   363960
gggagaagat gtggatctca acgaagacga cgacgagttt tcagatgacg atgctgaaac   364020
cagcgaggaa taagagttag ctattgacaa ttatcctatt tttaggtatc atattgtttg   364080
ggcacctctt ttagaggtcg gggctcccta gttcttaggg agctattttt gttttttcaa   364140
gaagttatct tcttgtattt tatactcaat gaaaatcaaa gagcaagcta ggaaactagc   364200
cgtaggctgc tcaaaacact gttttgaggt tgtagataag actgacaaag tcaggaacac   364260
atatctacgg caaggcgacg ttgacgcggt ttgaagagat tttcgaagag tattagttgt   364320
gaatctggtg cagtcgtccc agattattct tattagtagg gtcttgtttt ctatatcccc   364380
tcgtagttaa caagaccttg agcattttag aaagaggaat ctatgtctac gaaatatatt   364440
tttgtaactg gtggtgtggt atcgtccatt gggaaaggga ttgtggcagc gagtctaggc   364500
cgtctcttga aaaatcgtgg tctcaaagta accattcaaa agtttgaccc ttatatcaat   364560
attgatccgg gaaccatgag tccttaccag cacggggaag tttttgtgac agatgacgga   364620
gctgagacag atttggactt gggtcactat gaacgtttca tcgatatcaa tctcaacaaa   364680
tattccaacg tgacaactgg gaaaatttac agtgaagttc ttcgtaaaga acgccgtgga   364740
gaataccttg gggcaactgt tcaagtcatt cctcatatca cagatgcttt gaaagaaaaa   364800
atcaagcgtg ccgctctaac gaccgactct gatgtcatta tcacagaggt tggtggaaca   364860
gtaggagata tcgagtcctt gccattccta gaggctcttc gtcagatgaa ggcagatgtg   364920
ggtgcggata atgtcatgta tatccataca accttgcttc cttacctcaa ggctgctggt   364980
gaaatgaaaa ccaaaccaac ccaacactct gtcaaagaat tgcgtggctt gggaatccaa   365040
ccaaatatgt tggttattcg tacagaagag ccagctggtc aaggaattaa aaataaactg   365100
gcccagttct gtgatgtggc accagaagcc gttatcgaat cgttggatgt tgaacacctt   365160
taccaaattc cactgaactt gcaggcacaa gggatggacc aaattgtttg tgatcatttg   365220
aaattagacg caccagcagc ggatatgaca gaatggtcag ccatggtgga caaggtcatg   365280
aacctcaaga aacaagttaa gatttccctt gttggtaagt atgtggagtt gcaagatgcc   365340
tatatctcag tggtcgaagc cttgaaacac tctggctatg tcaatgatgc agaagttaaa   365400
atcaattggg tcaatgccaa tgatgtgaca gcagagaatg tagcagaact cttgtctgat   365460
gcggacggga tcatcgtacc aggtggtttt ggtcaacgtg gtacagaagg gaaaatccaa   365520
gccatccgct atgcgcgtga aaatgatgtt ccaatgttgg gagtctgctt gggaatgcag   365580
ttgacatgta tcgagtttgc tcgtcacgtt ttaggtcttg aaggtgccaa ttctgcagag   365640
cttgcaccag aaacaaaata ccctatcatt gatatcatgc gtgatcagat tgatattgag   365700
gatatgggtg gaacccttcg tttgggactt tatccgtcta agttgaaacg tggctctaag   365760
gctgctgctg cttatcacaa tcaagaagtg gtgcaacgcc gtcaccgtca ccgttatgag   365820
tttaataatg ccttccgtga gcagtttgag gcagcaggtt ttgtcttttc aggagtttct   365880
ccagacaatc gtttggtaga aatcgtggaa attcctgaaa ataaattctt tgtagcttgt   365940
cagtatcacc ctgaactgtc aagccgtcca aaccgaccag aagaactcta cactgccttt   366000
gttactgcag cagttgagaa cagcaattag caaaatcaga acctttgaga aaaatctcag   366060
aggttttttg catacgatga tattgcagta tatctgaggt aggggtcctc tgtatgtacc   366120
tgctaccgtt gaaatcaata gcgactccct cttgccctgt gctagtgaat ggatttatca   366180
gtatattgaa atgaaataaa atttgaacaa attaattcgg aaagccaaat caatttctag   366240
caaagtttta ggaactggat tgtatagtga attgaaataa gatgtgaaca tctctatcag   366300
gaaagtcaaa ttaatttata gaaatatttt agcagtcaag atgtactgtt atagattcaa   366360
tacattatac ttttttaatt taatccacta tagtaaaatg aaataataac aggacaaatc   366420
gatcaggaca gtcaaatcga tttctaacaa tgttttagaa atagaggtgt actattctag   366480
tttcaatata ctatcccaaa tcattcatac ctctctcaac tagatgtaac ttacaaaacc   366540
cctgacctca tgagccactt tcttcctcct catgaggtca gttttacttt ctgctgttcc   366600
agtatcgttt ttcctcgcta gatttcctca aaagggcaga ctcctccctt ggtgcgtcac   366660
acgatttttt catctcgact gttctttaat gcatcattaa cgacgctttt cttctaggtg   366720
gttcataagg aacaggaaga ttcaggttga cttttctaat cctagaataa agtgctgaaa   366780
acaattcgga ataggcatag agactagaca atttgaggag ctgcttgcgt cctgttcgaa   366840
cacattttcc caccacgtga agaaaaagat ggcggaagcg tttgattgtt aaagtttgga   366900
agtcacctcc agctagatgt ttgagaaaaa gatagagatt gtaggcgata cagctcatca   366960
tcatacgaac ttcgtttttg attaaggttg aactatccgt tttatcgcca aaaaatccct   367020
ccttcatctc cttgatgaaa ttctcggctt gaccacgtcc acgataaagc tgaaactggt   367080
cttggcttgt tccactcgtc atatttgtaa cgagagaaat aacatcgtag aacaagtttc   367140
cttcttttcg ttcagagaac tggcagacac gacgcttgtg cgaccaagat cctgcttgat   367200
agagagtttc tgagtaggcg gagtggggca agatggttaa gtcctcatcc tgtgggcaag   367260
ggagggaaag gtctccaaga cggctcagaa cagtattttt cttgagtttt atgaggtagt   367320
attgccctgt tttttcaatt aaatcgtata attttggggt cgcaaagcca ctatccattc   367380
gaaagagaag ttgattaaac cgttctaaaa caggtgtgat aaagctgtct gcctcttcag   367440
aacaataacg attaccagga cgaagctggg cattgaaaca ataacctgtc ttcccctcga   367500
aagcataaag aggatgatag ccatgagcac gatagtgggc gttataagca acaccttctt   367560
gcttgccata agttgtgaaa tgggtagaat cgatatctac aatgagttgg tttagctggt   367620
gaaactgtaa aaagaattcg accaattcaa ggttgaggca tcgcaaacta tggactgttt   367680
cctcgtcagt tctggaaaga aaacgggata aggttggctg tgaagcaagc tgccctcctt   367740
ccaacaattt tggaaagtag gcatcagctg acaattcttt acaagcatag tccgttccat   367800
aacctgttaa cagttgaaag aggaactgga caaggatatc tgaatccgaa taacgacagt   367860
agcggcgttg gtcattcgtt actaaatact tagaaatccg ctcttttagt ttcaactggg   367920
aaaaaagttc ctgaaaaaag ataagaccac catactgggt taaatgacct ccatcgaaag   367980
atagttggta aaaagacttg ttttggaagt gatgatttgg taaactgttc atgtgagttt   368040
cctttctttt tgtgtttttt tctacactta taccataaag gggaaactct tttttgtcta   368100
gtaaaaaaca cccattgggt gaaaaaagaa accatccagg atctaagcta aggcaaggat   368160
tctggatggt ttttagattt ggggtgaata attggggact atatatctgc agaatactct   368220
ttcagtttca ttcatcctag tcttgcttag gaaaaagtaa aaagccatcc aattatgatg   368280
gatagcttct tggttcttag atttgttctg caaaaacctt ttcagcaagg ttcatagcgt   368340
ggtctgatac acgagtgtag tgtgagatga tgtcgataaa gttgacccca gcttgtgttg   368400
aacattcgcc tttgttgagg cgtttgatgt gggtttttct gagaacacgt tctatcttat   368460
tgattgcttc atgacgttct acaagactgc gtgctttttc aatatcattg ttttccacac   368520
tatccagagc atctttgata aagtcactag tttggcggta aacttcctct aattctttca   368580
aggcggcatc agaaaattca acatttttcc gttgaagata gtcagtcaga ttgagtagag   368640
cctccgtgtg gtctccaatc cgttccaaat cacgggagga atcaaggata ttggtaagca   368700
cttcactttc tttttggctg agagcttcgc ttgaaagggc aatgagataa cgtgttaatt   368760
gctcatcgat ggtgttaatt gcttcttcgg ttttatgccc tttttcagca actttttcat   368820
ccaagtcaat gatgtactta taggaaaggt caaaggcttt agcagcgtag tttcctaagt   368880
gcaagagctc tttcttagca tttcctagag cgatagatgg ggcctgtttg atgaaatgtt   368940
catcaagata taagggttcg tatttgacaa cctcgtcctc tccaggaata atcttggtta   369000
caaagtaagc cagagctccg ataaatggaa attggacaat ggtgttggta atattaaagg   369060
ttccgtgagc aaaggcgatg gtcatttccg gtgctagatt tagcgtagct tcaaaccaat   369120
gaatcaggac agtaaaagga actagaaaaa taacgcagac aactgttccg ataacgttga   369180
aggcaacatg agctcctgct acccgtttag ctgcaatatt agcccctaaa gaggcaatga   369240
tggctgtaat ggttgtcccg atattgtcac caaatagaac tggcaaagct ccctgtagat   369300
caattagatt gccggcgtag aggttttgta aaatcccaat ggtagccgaa gaagcttgaa   369360
ttagcaaggt caagccagta ccgacaaaga cacccaaaac aggattctta cttagctcaa   369420
tcatatagtc cttaaagacc tgtaaatcct tgagtggagc cattgcgccg ctcatgagat   369480
tgagggcaaa aaagatacca ccgacaccaa agaggatgcg tccgatatta ttgactgtcc   369540
gatttttcgt aaaaaaaaga cagacggcac cgataaagag cataggtagg gcatagttac   369600
ctaatttaaa accgatgaga aaggatgtga cagttgtccc aatattagca cccatgacaa   369660
tcccgatagc ctgacgtaag gttaagagac cggcactgac caggccgact gtgataactg   369720
ttacaccaga actagactga attagagcag tcatcccaat accaaccaga actccaaaga   369780
aaggattact agtatatttg tcaatgtaaa aacgaaggcg atctccagca gcttgttgta   369840
aaccgtctcc catggtcttg atgctatata agaatagccc cagaccacct aaaaagtgaa   369900
ataaaatttc ctgccaatta atggacattt ctttttcctc cgaaaaataa tcgcggaata   369960
tctcctattc tattttaaag gataaaagta aatctaacaa gtgttaatgt caagtttgta   370020
aaagaaaatt ataattgata agtgtattat ttttaagagt ttttaacctt attttagatt   370080
tgtgcaaaca gttattggtt tttgtctaaa aatgttttag gataaaaatg tgattatcat   370140
ggttctagag tttgataaaa aactacagaa tataaagcgc tttcttgaaa acaacaaaat   370200
caatctttta ggaggagaaa atgaagaatc cattttttga aagacgttgt cgttacagta   370260
ttcgtaagtt atcagtagga gcctgctcgc tgatgattgg tgctgtttta tttgctggtc   370320
cagccttggc tgaagaaact gcagttcctg aaaatagcgg agctaataca gagcttgttt   370380
caggagagag tgagcattcg accaatgaag ctgataagca gaatgaaggg gaacatgcta   370440
gagaaaacaa gctagaaaag gcagaaggag tagcgatagc atctgaaact gcttcgccag   370500
caagcaatga agctgcaact actgaaactg cagaagcagc tagcgcagct aaaccagagg   370560
aaaaagcaag tgaggtggtt gcagaaacac catctgcaga agcaaaacct aagtctgaca   370620
aggaaacaga agcaaagccc gaagcaacta accaagggga tgagtctaaa ccagcagcag   370680
aagctaataa gactgaaaaa gaagtccagc cagatgtccc taaaaataca gaaaaaacat   370740
taaaaccaaa ggaaatcaaa tttaattctt gggaagaatt gttaaaatgg gaaccaggtg   370800
ctcgtgaaga tgatgctatt aaccgcggat ctgttgtcct cgcttcacgt cggacaggtc   370860
atttagtcaa tgaaaaagct agcaaggaag caaaagttca agccttatca aacaccaatt   370920
ctaaagcaaa agaccatgct tctgttggtg gagaagagtt caaggcctat gcttttgact   370980
attggcaata tctagattca atggtcttct gggaaggtct cgtaccaact cctgacgtta   371040
ttgatgcagg tcaccgtaac ggggttcctg tatacggtac actcttcttc aactggtcta   371100
atagtattgc agatcaagaa agatttgctg aagctttgaa gcaagacgca gatggtagct   371160
tcccaattgc ccgtaaattg gtagacatgg ccaagtatta tggctatgat ggctatttca   371220
tcaaccaaga aacaactgga gatttggtta aacctcttgg agaaaagatg cgccagttta   371280
tgctctatag caaggaatat gctgctaagg taaaccatcc aatcaagtat tcttggtacg   371340
atgccatgac ctataactat ggacgttatc atcaagatgg tttgggagaa tacaactacc   371400
aattcatgca accagaagga gataaggttc cggcagataa cttctttgct aactttaact   371460
gggataaggc taaaaatgat tacactattg caactgccaa ctggattggt cgtaatcctt   371520
atgatgtatt tgcaggtttg gaattgcaac agggtggttc ctacaagaca aaggttaagt   371580
ggaatgacat tttagacgaa aatgggaaat tgcgcctttc tcttggttta tttgccccag   371640
ataccattac aagtttagga aaaactggtg aagattatca taaaaatgaa gatatcttct   371700
ttacaggtta tcaaggagac cctactggcc aaaaaccagg tgacaaagat tggtatggta   371760
ttgctaacct agttgcggac cgtacgccag cggtaggtaa tacttttact acttctttta   371820
atacaggtca tggtaaaaaa tggttcgtag atggtaaggt ttctaaggat tctgagtgga   371880
attatcgttc agtatcaggt gttcttccaa catggcgctg gtggcagact tcaacagggg   371940
aaaaacttcg tgcagaatat gattttacag atgcctataa tggcggaaat tcccttaaat   372000
tctctggtga tgtagccggt aagacagatc aggatgtgag actttattct actaagttag   372060
aagtaactga gaagaccaaa cttcgtgttg cccacaaggg aggaaaaggt tctaaagttt   372120
atatggcatt ctctacaact ccagactaca aattcgatga tgcagatgca tggaaagagc   372180
taaccctttc tgacaactgg acaaatgaag aatttgatct tagctcacta gcgggtaaaa   372240
ccatctatgc agtcaaacta tttttcgagc atgaaggtgc tgtaaaagat tatcagttta   372300
acctaggaca attaactatc tcggacaatc accaagagcc acaatcgccg acaagctttt   372360
ctgtagtgaa acaatctctt aaaaatgccc aagaagcgga agcagttgtg caatttaaag   372420
gcaacaagga tgcagatttc tatgaagttt atgaaaaaga tggagacagc tggaaattac   372480
taactggctc atcttctaca actatttatc taccaaaagt tagccgctca gcaagtgctc   372540
agggtacaac tcaagaactg aaggttgtag cagtcggtaa aaatggagtt cgttcagaag   372600
ctgcaaccac aacctttgat tggggtatga ctgtaaaaga taccagccta ccaaaaccac   372660
tagctgaaaa tatcgttcca ggtgcaacag ttattgatag tactttccct aagactgaag   372720
gtggagaagg tattgaaggt atgttgaacg gtaccattac tagcttgtca gataaatggt   372780
cttcagctca gttgagtggt agtgtggata ttcgtttgac caagccacgt accgttgtta   372840
gatgggtcat ggatcatgca ggagctggtg gtgagtctgt taacgatggc ttgatgaaca   372900
ctaaagactt tgacctttat tataaagatg cagatggtga gtggaagcta gctaaggaag   372960
tccgtggtaa caaagcacac gtgacagata tcactcttga taaaccaatc actgctcaag   373020
actggcgctt gaatgttgtc acttctgaca atggaactcc atggaaggct attcgtatct   373080
ataactggaa aatgtatgaa aagcttgata ctgagagtgt caatattccg atggccaagg   373140
ctgcagcccg ttctctaggc aataacaagg tacaagttgg ctttgcagat gtaccggctg   373200
gagcaactat taccgtttat gataatccaa attctcaaac tccgctcgca accttgaaga   373260
gcgaagttgg aggagaccta gcaagtgcac cattggattt gacaaatcaa tctggtcttc   373320
tttattatcg tacccagttg ccaggcaagg aaattagtaa tgtcctagca gtttccgttc   373380
caaaagatga cagaagaatc aagtcagtca gcctagaaac aggacctaag aaaacaagct   373440
acgccgaagg ggaggatttg gaccttagag gtggtgttct tcgagttcag tatgaaggag   373500
gaactgagga cgaactcatt cgcctaactc acgcaggtgt atcagtatca ggttttgata   373560
cgcatcataa gggagaacag aatcttactc tccaatattt gggacaaccg gtaaatgcta   373620
atttgtcagt gactgtcact ggccaagacg aagcaagtcc gaaaactatt ttgggaattg   373680
aagtaagtca ggaaccgaaa aaagattacc tagttggtga tagcttagac ttgtctgaag   373740
gacgctttgc agtggcttat agcaatgaca ccatggaaga acattccttt actgatgagg   373800
gagttgaaat ttctggttac gatgctcaaa agactggtcg tcaaaccttg acgcttcatt   373860
accaaggcca tgaagttagc tttgatgttt tggtatctcc aaaagcagca ttgaacgatg   373920
agtacctcaa acaaaaatta gcagaagttg aagctgctaa gaacaaggtg gtctataact   373980
ttgcttcatc agaagtaaaa gaagccttct tgaaagcaat tgaagcggcc gaacaagtgt   374040
tgaaagacca tgaaactagc acccaagatc aagtcaatga ccgacttaat aaattgacag   374100
aagctcataa agctctgaat ggtcaagaga aatttacgga agaaaagaca gagcttgatc   374160
gcttaacagg tgaggttcaa gaactcttgg ctgccaaacc aaaccatcct tcaggttctg   374220
ccctagctcc gcttcttgag aaaaacaagg ccttggttga aaaagtagat ttgagtccag   374280
aagagcttac aacagcgaaa cagagtctaa aagatctggt tgctttattg aaagaagaca   374340
agccagcagt cttttctgat agtaaaacag gtgttgaagt acacttctca aataaagaga   374400
agactgtcat caagggtttg aaagtagagc gtgttcaagc aagtgctgaa gagaagaaat   374460
actttgctgg agaagatgct catgtctttg aaatagaagg tttggatgaa aaaggtcaag   374520
atgttgatct ctcttatgct tctattgtga aaatcccaat tgaaaaagat aagaaagtta   374580
agaaagtatt tttcttacct gaaggcaaag aggcagtaga attggctttt gaacaaacgg   374640
atagtcatgt tatctttaca gcacctcact ttactcatta tgcctttgtt tatgaatctg   374700
ctgaaaaacc acaacctgct aaaccagcac cacaaaacac agtccttcca aaacctactt   374760
atcaaccgac ttctgatcaa caaaaggctc ctaaattgga agttcaagag gaaaaggttg   374820
cctttcatcg tcaagagcat gaaaatactg agatgctagt tggggaacaa cgagtcatca   374880
tacagggacg agatggactg ttaagacatg tctttgaagt tgatgaaaac ggtcagcgtc   374940
gtcttcgttc aacagaagtc atccaagaag cgattccaga aattgttgaa attggaacaa   375000
aagtaaaaac agtaccagca gtagtagcta cacaggaaaa accagctcaa aatacagcag   375060
ttaaatcaga agaagcaagc aaacaattgc caaatacagg aacagctgat gctaatgaag   375120
ccctaatagc aggcttagcc agccttggtc ttgctagttt agccttgacc ttgagacgga   375180
aaagagaaga taaagattaa atatcgaaaa atcttgtgaa atctttcctt atatttccaa   375240
agtgtgatat aatagtttcg aataaaataa ataaaggagt ttttgtaaca tggcaaaact   375300
tactgttaaa gacgttgact tgaaaggtaa aaaagtcctc gttcgtgttg acttcaacgt   375360
accattgaaa gatggcgtaa tcactaacga taaccgtatc acagcagctc ttccaactat   375420
taagtacatc atcgaacaag gtggacgtgc aattcttttc tctcaccttg gacgtgtgaa   375480
agaagaagct gataaagctg gtaaatcact tgctcctgta gcagctgact tggcagcaaa   375540
acttggtcaa gatgttgttt tcccaggtgt cactcgtggt gctgaattag aagcggcaat   375600
caacgctctt gaagatggac aagttctctt ggttgaaaac actcgttacg aagatgttga   375660
cggcaagaaa gaatctaaaa acgatcctga acttggtaaa tactgggcat cacttggaga   375720
tggtatcttc gtaaacgatg cattcggtac agctcaccgt gcacacgcat ctaacgttgg   375780
tatctcagca aacgttgaaa aagcagttgc tggtttcctt cttgaaaacg aaattgccta   375840
catccaagaa gcagttgaaa ctccagaacg tccattcgtg gctatccttg gtggttcaaa   375900
agtttcagac aagatcggtg ttatcgaaaa cttgcttgaa aaagctgata acgtccttat   375960
cggtggtggg atgacttaca cattctacaa agcacaaggt atcgaaatcg gtaactcact   376020
tgtagaagaa gacaaattgg atgttgcgaa agctcttctt gaaaaagcaa atggtaaatt   376080
gatcttgcca gttgactcaa aagaagctaa cgcatttgct ggttacactg aagtgcgtga   376140
cactgaaggt gaagcagttt ctgaaggctt ccttggtctt gacatcggtc caaaatctat   376200
cgccaaattt gacgaagctt tgactggtgc caaaacagtc gtatggaacg gacctatggg   376260
tgtatttgaa aacccagatt tccaagctgg tacaatcggt gtgatggacg ctatcgtgaa   376320
acaaccagga gttaaatcaa tcatcggtgg tggtgactca gctgccgcag cgattaacct   376380
tggccgtgca gacaagttct catggattag tacgggtggt ggagcatcaa tggaacttct   376440
tgaaggtaag gttcttccag gacttgcagc cttgacagaa aaataagatt ttataaataa   376500
atcaaagaag agagggatga aagttcctct tttcttttgc ttaaaataaa aacgcttcct   376560
ctcaactatt actcataaaa atcaccgatt tatgataaaa tggaaataga aagttgagat   376620
tatgagttat tttaaaaaat ataaattcga taaatcccag ttcaaacttg gtatgcgaac   376680
ctttaaaaca ggtattgctg tttttctagt tctcttgatt tttggctttt ttggctggaa   376740
aggtcttcaa attggtgctt tgacagccgt ttttagcctg agggagagtt ttgatgagag   376800
tgttcatttt gggacttcgc gtattctagg aaatagtatc ggtggactct atgccttggt   376860
cttcttctta ttaaatacct ttttccacga agccttttgg gtgaccttgg tagttgttcc   376920
aatctgcacc atgttaacca ttatgacaaa tgtagccatg aataacaaag caggggttat   376980
tggtggtgta gcagctatgt taatcattac cctatcaatt ccaagtggtg agacaatttt   377040
gtacgtgttt gtgcgtgtat tagaaacgtt tatgggagtt tttgtcgcaa ttatcgtaaa   377100
ttacgatatt gatcgtattc gtctcttttt agagaaaaaa gaaaaataat gttacatttt   377160
ataacattat caattgacgt ttgtcttttt ttagactata atagacagaa agaaggaaat   377220
tgtaaatgaa ggaaaaagaa tttcgccgaa atatggctgt ttttcctatc ggcagtgtta   377280
tgaagttgac cgatctatcg gcgcgtcaga ttcgttatta tgaagatcaa gagttgatca   377340
agcccgatcg aaacgaagga aatcgtcgca tgtattcctt gaatgacatg gatcgtctgc   377400
ttgaaatcaa agattatatc tctgaaggtt ataatatcgc tgccattaag aaaaaatatg   377460
ctgaacgtga agcgaaatcc aagaaagcgg ttagtcagac tgaagtacgt cgtgcacttc   377520
acaatgaact cctccaacag gggcgttttg cttcagtaca gtcacctttt ggtcgcggtt   377580
aggcaaccgc aagtagtcat agattaagga gaaaacttat gccaatcaca gctgcagata   377640
ttcgtcgtga agtcaaggaa aaaaatgtta cctttattcg tcttatgttc tcagatattt   377700
tgggaaccat gaaaaacgtc gaaattcctg ctacagatga acagttagat aaggtcttgt   377760
cgaacaaggt tatgtttgat ggatcttcta ttgaaggttt tgtacgtatc aatgagtcgg   377820
atatgtactt gtacccggac ttggatacat ggacagtctt cccttgggga gatgaaaatg   377880
gaagtgttgc aggtctgatc tgtgatgtct atacaacaga aggtgaacca tttgcgggtg   377940
accctcgtgg taatttgaaa cgagctcttc gtcacatgga agaagttgga ttcaaatcct   378000
tcaaccttgg tccagagcca gaattcttcc tatttaagtt ggatgaaaat ggggacccaa   378060
cacttgaagt gaatgacaag ggtggctact ttgacttggc acctactgac cttgcggaca   378120
acacacgtcg tgagattgtg aatgtcttga ccaaaatggg atttgaagta gaagcgagtc   378180
accacgaggt tgcggttgga cagcatgaga ttgactttaa gtacgatgaa gttctccgtg   378240
cttgtgataa gattcaaatc tttaagcttg ttgttaaaac cattgctcgc aaacacggac   378300
tttacgcaac atttatggcg aagccaaaat ttggtattgc tggatcaggt atgcactgta   378360
atatgtcctt gtttgatgca gaaggaaata acgccttctt tgatccaaat gatccaaaag   378420
gaatgcagtt gtcagaaaca gcttaccatt tcctaggcgg tttgatcaag catgcttaca   378480
actatactgc catcatgaac ccaacagtta actcatacaa acgtttggtt ccaggttatg   378540
aagcgcctgt ttacattgct tgggctggtc gtaaccgttc gccacttgtg cgcgtacctg   378600
cttcacgtgg tatgggaact cgtcttgagt tgcgttcagt ggatccaatg gcgaaccctt   378660
acgttgctat ggctgttctt ttggaagttg gtttgtatgg tattgaaaat aaaatcgaag   378720
caccagctcc tatcgaagaa aatatctaca tcatgacagc agaagagcgc aaggaagctg   378780
gtattacaga ccttccatca actcttcaca acgctttgaa agctttgaca gaagatgaag   378840
tggttaaagc tgctctcgga gatcacatct atactagctt ccttgaagcc aaacgaatcg   378900
aatgggcaag ttatgcaacc ttcgtttcac aatgggaaat tgataattat ttagaccttt   378960
actaatacta atatagaaga aagattgcct gtgggtaaac agtcacacag cagtctaagc   379020
catcaaatac ctataaccct taaaatagcg atttcggtcg ctatttattt ttcgaaaaat   379080
cctcttgact cttttgcgaa ttagatttat catcagacgt gtagaagaaa attaaggagt   379140
cactatggaa aaattcaatt tcaaaaacaa tatcgggcaa gaaaacaagt tacttcaaat   379200
cgaaatctac aagtttacta acttttgcaa gcttcaaaat tacacatctg taaatatttt   379260
ttcgaaagat atatttgaag ccatagtaaa ttgagactag aatagtacac tacatctgct   379320
aaaaatttct agaaactaat ttaactttcc taatcgattt gtttacatct tatttcaatc   379380
tactatatta tctcaataaa tgatgatggc gactgttttg tttgtgcttg tcgatttttg   379440
aatcctgatc gagcggaaga atatttctgc cgaggttgcc aaggggaaaa tcctgaagat   379500
attgaatttt atgatgaaca attacaggca gaaaaggtgg aggatttgaa tattcgattg   379560
gaagtaaaaa attgaattat ctacaatctc atcaacaata aacctatttc aaccccatta   379620
tctataggcg tatttttacg cctttttata tacttgaagc acataagaaa cattatggga   379680
agtttgctga tggaagcact caagaaattg atgttcctta tgatattcct gatacttggg   379740
agtgggtgag gataaaatca atttattgga attttgggca aaataagcca gagaaatcct   379800
ttaggtatat agatacgtct agtattgata gaaaaaagaa cataatcaac tacaaaaatc   379860
tacaatatct ttcacctgaa caagcgcctt cccgtgctag aaaattagtt tcgcagaata   379920
gtgtcttatt ttcaacagtt agaccatatc taaaaaatat tgctgtagtt agagaactta   379980
aagagtattt gatagctagt acagcattta ttgttttgga tactttactt aacgaaacat   380040
atttgaaata ttatttatta tcagataatt ttatcaatcg tgttaataat aaatctactg   380100
gaacaagtta tcctgcaatc aatgattata attttaatct attattaatt gctctccccc   380160
cactatccga acaacaacga atagtagaag caatcgaatc agctttagaa aaagtagatg   380220
aatatgctga aagttataat agactagaac agctagataa agaatttcca gataaactaa   380280
aaaaatctat tcttcaatat gctatgcaag gaaaattagt tgaacaagac ccaaatgatg   380340
aatcagtcga agttttactt gaaaaaatac gagcagaaaa acaaaaactc tttgaagaag   380400
gcaagattaa aaagaaagat ttggacattt ctattgtttc ccaaggagat gataactctt   380460
attatgagga agtaccttgt gaaataccag aaagttggga atgggtgagg ttaaacgata   380520
taacctccta cattcaaaga gggaagtctc caaaatattc aaatattcct atataccctg   380580
tgattgctca gaaatgtaat caatggtctg gcttttctat tgacttagca agatttattg   380640
atcccgaaac agttcatagt taccagaaag aaagattact aagagatggt gatttaatgt   380700
ggaattcaac aggtctaggt acgttaggac gattagctat ttaccatgaa aataaaaatc   380760
cttatggctg ggctgttgca gatagccatg ttacagttat aagagtctta tcgggggtta   380820
ttaattgcca tttcatctat aattttcttt cctctcctat tgttcagtca gttattgaag   380880
aaaaagcgtc gggtagtaca aaacaaaaag aattattaac gaaaactata aaagaatatt   380940
taatccccct cccacccctt cctgaacaat ccagaatcgt tgataaaatc gaacaatttt   381000
tcgcccatat tgacgcacta atttagtata atagttttac gtgcggtgga atttctatca   381060
aacataagat aggagtttta cgttgaaaga ttttgaatta catttgaaga aagctggttt   381120
agctgaaaat actgtgcgtt cgtaccttta tggtgttcga tttttcttgg agaattacga   381180
actcaaaatg gaagatttat ttgaatacaa aggatattta ttagacaatt ttaaacctaa   381240
aactgtcaat ttgcgactac aaggagtaaa taaatatctg gcttttattg gtcatgatga   381300
tttgaaatta aaatttgtca aagtacagca aaaaccgttt ttagaagatg tcattagcca   381360
tgctgattac ctttttctta aacgtagttt gaaaaaagat ggtattttaa aatggcattt   381420
tgtcgtttgg tttttaggtg caactggggc tcgtgtaagt gaacttatta aactaaaagt   381480
agagcatgta gaaatcggtt attttgacat ttactcaaaa ggtggtaaaa ttcgtagact   381540
gtacattcct aaaaaattaa gaaatagttg tcttagttgg ttagaatcag aaaatcgccg   381600
aagtggttat ttatttttga ataaatttaa cgaaccaatt acagcaagag gagttgctca   381660
acagttaaaa aattatgctg ataaatacaa aatgaatcct aaagtaattt accctcattc   381720
ttttaggcat ttatttgcta agaatttttt agcgaagtat aatgatattg ccttgcttgc   381780
agatttgatg ggacacgaaa gtatagaaac tactcgaatt tatctaagga aaacagctac   381840
tgaacaacaa aatattgtag ataaaattgt taattggtaa aaaataacag gtggtcaaac   381900
tgactacctg ctatttttgt gattatggct cttattatgg gaatatacct atgaattggg   381960
ttgttataaa aataaaagat attttttcaa taaatacagg tctttcttac aagaagggcg   382020
atttaagcat taataataaa ggtgttagaa ttatacgtgg tggtaatatt aagcctttag   382080
aattttctct gttggataat gattactaca ttgatacaca attcatctcc tctgagcaag   382140
tttatttaaa acataatcag ctaataacac ctgtatcaac ctctttagaa catattggaa   382200
agtttgcaag aatcgataaa gactatgatg gtgttgtggc tggtggattt attttccaat   382260
taacaccatt cgaaagttca gagattattt caaaatttct attatttaac ttgtcctctc   382320
cgttatttta taaacaattg aaagcaataa ctaaactatc aggtcaagct ttatataata   382380
ttcctaaaac tacactgagc gagctattaa ttccgttagc tccttttgag gaacaggaac   382440
ttattactca aaaagttgag aaactttttg aaaaagtaaa tcaactttga aaatgattct   382500
tttcatctct tcatgattag aaatagggat taataattcg gagatactgg tactatttaa   382560
tgttttccct ttgatagcat cttttgaatc acctaaagta gagataagtg gcaaaaatat   382620
cattaagtaa tctctgataa tattttcttt attagcatag gggaatatcg atataatggc   382680
ttcattatga gtggcaggaa tatccaatat ggcaactttt ccaatagata atttaaaact   382740
cattaataaa gttcctttag gtgaaatgtc tattttcttt gattttaatg ctaatttaga   382800
aatagattct ctcgcattag ttacataacc agatataggc atatctgata tagataccca   382860
aggtatttca gttccccaaa aagtagcttc actgcgtgga ggagtttttc ctattctgaa   382920
gttaactagg ctagcaaatt taatatatct ccatgcttct gggatttcat atataggata   382980
agaggttgtt tcgtctttgt tcccataata agagttatca tctccttggg aaacaataga   383040
aatgtccaaa tctttctttt taatcttgcc ttcttcaaag agtttttgtt tttctgctcg   383100
tattttttca agtaaaactt cgactgattc atcatttggg tcttgttcaa ctaattttcc   383160
ttgcatagca tattgaagaa tagatttttt tagtttatct ggaaattctt tatctagctg   383220
ttctagtcta ttataacttt cagcatattc atctactttt tctaaagctg attcgattgc   383280
ttctactatt cgttgttgtt cggatagtgg ggggagaggg ataagaatag aagcaacttt   383340
atcactattc aagtttttca caacagctcc actaattaga gatagaaatt gagaataaac   383400
tacatttgat gaaagaatat agaataggta atctttattt aatgagtttt catagttcga   383460
aatagccaac catccatcgt gtattgcacc atcaacattc aaaatataag gtctaccaaa   383520
actcatagaa ttagttaaca aaaatgtacc tttttttaca aatctagttt tgttaagccc   383580
tgattttttg attttttctt taacattatt tatatacttt tcaccctttt cagtatcacc   383640
tatttttatc caatttattc catctacttc agaagtaaga taatctttga ttggtcgtgg   383700
agagccacct ctgacaattt caaccaatgt agaaaacctc acccactccc aagtatcagg   383760
aatatcataa ggaacatcaa tttcttgagt gcttccatca gcaaacttcc cataatgttt   383820
cccatcatca ccacgaaata tctcagtttc ctttttatct cgtttgattt ttccttcact   383880
gataagtttt tctttttcag ctttaattct ctttaataat tcacttgcag gttcgtcatt   383940
gggattttgc ggcactaatt tcccttccat cgctctttgg agaatacttg ctttaagttg   384000
ttctggtgtc attatttgtc ctccaacaac tgcaaaatat cagctaatac attatcaatc   384060
ttatgattta aagttgctct ttccgcttga taattctgaa tcaactcaaa gggatttaag   384120
atttcctctt cctcttttgg aaagtcacac tggtctaaat tataattcaa ctcagccaat   384180
tcactaggtg taaatgattt agatttgtag aacttacctt ccagaatctc ttcacgattt   384240
tcccaccagt cacgaacagg attgaagtgt tctgacttca tcggcttagt tttcgagaaa   384300
tttttataac catctggcat atctaaacga taaaaccaag tttcttctgt tttctttgtt   384360
ttatcaaaga aaagaatgtt cgtatggatt cctgtatacg gtgcaaagac actatgaggc   384420
aacctaataa tcgtatgcaa gttgaactca tctaccagtt tttgtttcaa gcgagttttt   384480
acaccttcac caaatagaaa accatcaggt aaaataactc caacacgacc attttctttc   384540
aaacgataca taatgacagc cataaataaa tcagctgttt cagaactccg taattctgct   384600
ggaaagttat tttttattgt ttctaattct gaccctccaa aaggtggatt catcataata   384660
atgtcaaatt tttcatcatc cgtatattca cgaacatttt tctccaaagt atttccatga   384720
acaattttag ggtcatcaat ttcgtgaaga aacagatttg taactgctaa aagatgagga   384780
aatgctttct tttcaatacc aaaaacagct gtattatatt ttttggtatc ttcactagtt   384840
ttacgttgac tacttaaacg gttcagagtc gaagtcaaga agcctcctgt tccgcaagca   384900
aggtctgcca ttgattctcc aagttttggg tcaagaactt cggcaataaa atcagtcgct   384960
gcacgtggcg tataaaattc tcctgagttc ccagcatttt gaatatcttt aagaattttt   385020
tcgtaaatat cattaaacga atgacgatct tcagggctat tgaaatcaac ttcatcaata   385080
acattgatga cttggcgtaa caagacgcca tttttcatat agttgttcgc atcttcaaaa   385140
gctgatttaa caatcgtttt tcgaataggc atatttgaag ttatttcaag ctctttcaac   385200
tctttgaata acttgttatt gacaaaatca agtaattcat cgcctgtcaa tacccgttcc   385260
ccattttgag catgagccca atttcgccat tttaattcct ctgggataat tgactcatac   385320
tcgtcttctt ctaattccca aaccatttca cggctatcat aaatttttaa gaataataac   385380
caagacattt gctcaatacg ttgagcatca ccattaacac cagcatcgtt tcgagtgata   385440
tcttgaattc tttttacaaa tgatgtaatt gacatacttt cctttcatta agctactgta   385500
aatagctctt gctccaattc tttaattgct tgtaaatatc gttttttatc tccaaaataa   385560
gtattgatga ttttgaaggt tccaccatat atctgaaatt ctggaagttt taatgtttca   385620
atgctttcga gttctccaat acctttatcc atgtatttgt tcagtaaaat ttccaaaaca   385680
gcacgcgctt cctcactata tttatataaa tatccgcttt gtttgagttt attgatacgt   385740
tccgttttgg ttaattcttt ttgaccatag gcaagtttta ggagtaaatc aaaatcatcg   385800
atttcttgtt ctgatattcc ctccgactct cgaatagcat ctagataaac tcctttttta   385860
taaagttcgt ctaagataag cttcttctta tctgccgtat gccaaactgt gataaaatcg   385920
ttcaaagtgg cgtagctacc taagatattc tttcgagtgt agtcggtcag gctttcggta   385980
atcagtttcc cgttttcatc caatacttga acagtagaat taagaatggt aacctgcttg   386040
tctgtaacga tatatttttc tactgggtca ccttcctcat ctacgaaacc gggcgtagaa   386100
ccactgactg ttttcgcacc tgtttctagc accttcactg gatcaccatc aaaatcaggg   386160
tcagcaaaca aattggtaac atttcgaaaa tcaataatcg taaaaaattc tttccccttt   386220
tgaggataaa gacgtgtgcc acgaccaata atttgtttaa attcagtcat ggattggata   386280
ttagagtcta aaacaatcaa acgacatgtt ttagcattaa ctcctgtcgt taataattta   386340
gacgttgtta caatagcggg aaaattagaa ttgacatcca taaagttatc cagttgagct   386400
tttccttcag cgttgtcacc agttacttgc atgacataac gatagtcttc ttggactaag   386460
tctagattct cttttacaag tgcagcacgc attcgctcgg catggtcaat atcaacacaa   386520
aaaacaattg ttttatcaaa tcgtgcattg ttttgcttca tataatcaga aacaaacttg   386580
gcaactcttt gcgttctatc atcaatgaca atggttttat caaaatcttt cctgccgtag   386640
tacctatctt ctattaattg tccgttagca tcaacttttc cagtttctgg acgataacca   386700
tccacatcca catctaaatt aaccctcata acacgatatg gagccaaaaa accatcctcg   386760
attccctgtt ttaaactata agtatagatt ggctcaccaa agtattccgt attggaagca   386820
ttcttggttt ctttaagagt agcggtcatc ccaatctgtg tcgcagaact gaaataatca   386880
attaccttac gccagttact gttttcctta gctgaaccac ggtgcgcttc atcaattacg   386940
attaaatcaa agaagtcttt gtcaaatttt tgataatgtg tttcagttcc atcttcacca   387000
gttagttgct gataaagccc tagataaatt tcaaaagaat ttaatttttc aggagcagtc   387060
aaaagttttg gtgtaatttt cgtcattacc ttttcgaatg gcctaaagtc ttcagccatc   387120
gtttggtcta ctaagatgtt tctatctgct aagaataaaa ctcgtttagc caaaccagct   387180
tttcgaaggc gatgaataat ttgaaaagcc atgaacgttt tccccgttcc tgttgccatc   387240
acaaacatta ctcgtttttg tcctctggca actgtttcaa tagtacggtt gatagctatt   387300
tgctgataat agcgtggcgt tttcattgag aaggcgtctg tatagtatgg agttgagata   387360
gcttctgtaa tttcgtacgt caatcctttt tccttcgtca tacgagaaaa taattcttca   387420
cgagtaggga attcgtctaa ctccagctca cgttcttctc tcgtgatacg gtcgtgttca   387480
ataaagccat caccattcga agaataaaca aatggaacat ctaaaatctc tccatattca   387540
atagcttgtt gtaatcctgc tcgaacgctg tgtttattat cctttgcctc aacaattgca   387600
attcgagttc caaattggta atacagtgaa tagtctgatt tttttccttc tttacgacga   387660
gccttatctc ctctaacttc aattcgacca tcagtgaagt attcttcgta agcgatatgc   387720
tcaccatttt tccatccttt ggatacaata gcaggagtga tgaaatttgc tttaatatcc   387780
tcctcactca tttctttctt agactttata aactcaacca tattgaaccc tccgcattct   387840
aaaaatctac ttctccataa aataaactat cagaacaaat tatacttcta ttatatcaca   387900
cttataaaaa tactctgcta aattgttgaa aataagtatg caatatactt tcgcatcgcg   387960
tcagattatc tccgcataac accgctattt ttcgctgttt tcggcaggcg acttattatc   388020
attctataag cactttcagt cgggctggtg atctattttt caaaaataaa taatcacatt   388080
taaacatttt gaaagtataa aatatctaca tcagccgttc aaaaactggc gtaaattttg   388140
ccataatatt ttcgtttaaa taaagatttt tttatgccaa acggatttta acaatgcgga   388200
tgcttcctat tttatttctc tttttagctc tactaccgtt tttctcaaag tttgtcactg   388260
gaggtagttc tttcagttgg aaagtgtttt tgattttcat aatagattgg gttttattga   388320
tagtttttgc gattcagatt tcttatattt tttggagatt gagtcaaaag tggaaagaat   388380
tatctaataa ataacgccag gcatgttttc taattttggg gtaagacaat gaatagcaga   388440
gtagaatttc ggattttcac cattgttgat ttggacaagg aagaagaaca tttacatgag   388500
atgcatttga aaggttggag gtatagaacg agtcgttttg gtttgttcta ttttgaccaa   388560
tgtcaaccag acgatgtcat ctaccgtatc tatgattcta gatttcttaa aaaagtataa   388620
gcatgaactg caagatttta gagatagagg ttgggaattg ataggagcag gttcttgttc   388680
gattcttcgt aaatcgtctt ctgatttact tccagaggat caagtctata tgagtaaagg   388740
gctcaaatgg gaagttatgc gatctagact tcgttcctgt acagctactt tctcaggtgg   388800
tcttgttgtt tgtatgagtt tgtttagaga ggatctttct atgtctttct ttcttatttt   388860
tgttttatat gcttttctga tttcttatct aatttatggt tatttcagac taaaaaggaa   388920
ataccgagta gatgaatagc aaggttctag gtcttcagat tgatttttag cactcttgat   388980
aaaagagtgc taattttttg agtttttgtc ttgacattct cttctaaggg tgtataatag   389040
aatcatgagt tagcacttgg atgcattgag tgctaattga tcagacagag aggagtgatg   389100
agatggttac agagcgtcag caggatattt taaatctgat tattgacatc tttaccaaaa   389160
cgcacgaacc tgtcggatca aaagccttgc aagagtctat taactctagc agtgcaacca   389220
ttcgtaatga catggcggaa ctagaaaaac aagggttgct tgagaaggct catacttcaa   389280
gtggtcggat gccaagtgtt gctggttttc agtactatgt gaaacactca ctggattttg   389340
accggctggc tgaaaatgag gtatatgaga ttgtcaaagc ctttgatcag gaattcttca   389400
aattggagga tattctgcaa gaggctgcta acttactaac agacctgagt ggctgtacgg   389460
tagtggcact ggatgttgag ccgagcaggc aacgtttgac agcctttgat atcgttgttt   389520
tggggcaaca tacagccttg gcggtattta ccctagacga gtcgcgaacg gttactagtc   389580
agtttctgat tccaaggaac ttcttgcagg aggatttgct gaaactgaag agcatcattc   389640
aggaacgttt cctcggtcac accgttttag atattcacta caagattcgg acggagattc   389700
cgcagattat ccagcgttac tttacaacaa cggataatgt catcgatctc tttgaacaca   389760
tctttaagga aatgttcaac gaaaacattg tgatggcggg caaggtccat ctcttgaatt   389820
ttgccaatct agcagcctat cagttctttg accaaccgca aaaggtggcc ttggagattc   389880
gtgaggggtt gcgtgaggat cagatgcaaa atgttcgtgt tgcagacggt caagagtcct   389940
gtttagctga cctagcggta atcagtagta agttcctcat tccttatcgg ggagttggaa   390000
ttctagccat tatcggtcca gttaatctgg attaccaaca gctaatcaat caagtcaatg   390060
tggtcaaccg tgttttgacc atgaagttga cagattttta ccgctacctc agcagtaatc   390120
attacgaagt acattaagat tgaaatcatt aaaggaggcg aacatggccc aagatataaa   390180
aaatgaagaa gtagaagaag ttcaagaaga ggaagttgtg aaaacagctg aagaaacaac   390240
tcctgaaaag tctgagttgg acttggcaaa tgaacgtgca gatgagttcg aaaacaaata   390300
tcttcgcgct catgcagaaa tgcaaaatat ccaacgccgt gccaatgaag aacgtcaaaa   390360
cttgcaacgt tatcgtagcc aggacttggc aaaagcaatc ttaccatctc ttgacaacct   390420
tgagcgtgca cttgcagttg aaggtttgac agatgatgtg aagaagggct tggggatggt   390480
gcaagaaagc ttgattcacg ctttgaaaga agaaggaatt gaagaaatcg cagcagatgg   390540
cgaatttgac cataactacc atatggccat ccaaactctc ccagcagacg atgaacaccc   390600
agtagatacc atcgctcaag tctttcaaaa aggctacaaa ctccatgacc gcatcctacg   390660
cccagcaatg gtagtggtgt ataactaaga tataaagccc gtaaaaagct cgcagtaaaa   390720
ataggagatt gacgaagtgt tcgatgaaca caagaaaatc tatctttttt actcagagct   390780
tagggcgtgt tcgattcggc aattctgacg gtagctaaag caactcgtca gaaaacggca   390840
atcgctatgg cgtttgccta gcttccttac taactcgtcg tcgaaataaa atcgatttcg   390900
actcctcgtg tcgcaattta cataatagaa aacttgtccg aaacgacaat aaactatgaa   390960
gaaagataaa atatgtttgg ctttgtaata gtgagcgaag cgaaccaaac acgatactct   391020
tcgccgtggc gctatttgcg caaattttga gaccttaggc tcaaagttta gtcaaagaga   391080
ttgacgaagt caagctctga cggcgtcgcc actgtcgcca cttaagaaga gtatcaaaaa   391140
gaaaaataga aaattaacta acaaggagaa aaacacatgt ctaaaattat cggtattgac   391200
ttaggtacaa caaactcagc agttgcagtt cttgaaggaa ctgaaagcaa aatcatcgca   391260
aacccagaag gaaaccgcac aactccatct gtagtctcat tcaaaaacgg agaaatcatc   391320
gttggtgatg ctgcaaaacg tcaagcagtt acaaacccag atacagttat ctctatcaaa   391380
tctaagatgg gaacttctga aaaagtttct gcaaatggaa aagaatacac tccacaagaa   391440
atctcagcta tgatccttca atacttgaaa ggctacgctg aagactacct tggtgagaaa   391500
gtaaccaaag ctgttatcac agttccggct tacttcaacg acgctcaacg tcaagcaaca   391560
aaagacgctg gtaaaattgc tggtcttgaa gtagaacgta ttgttaacga accaactgca   391620
gcagctcttg cttatggttt ggacaagact gacaaagaag aaaaaatctt ggtatttgac   391680
cttggtggtg gtacattcga cgtctctatc cttgaattgg gtgacggtgt cttcgacgta   391740
ttgtcaactg caggggacaa caaacttggt ggtgacgact ttgaccaaaa aatcattgac   391800
cacttggtag cagaattcaa gaaagaaaac ggtatcgact tgtctactga caagatggca   391860
atgcaacgtt tgaaagatgc ggctgaaaaa gcgaagaaag acctttctgg tgtaacttca   391920
acacaaatca gcttgccatt tatcactgca ggtgaggctg gacctcttca cttggaaatg   391980
actttgactc gtgcgaaatt tgacgatttg actcgtgacc ttgttgaacg tacaaaagtt   392040
ccagttcgtc aagccctttc agatgcaggt ttgagcttgt cagaaatcga cgaagttatc   392100
cttgttggtg gttcaactcg tatccctgcc gttgttgaag ctgttaaagc tgaaactggt   392160
aaagaaccaa acaaatcagt aaaccctgat gaagtagttg ctatgggtgc ggctatccaa   392220
ggtggtgtga ttactggtga tgtcaaggac gttgtccttc ttgatgtaac gccattgtca   392280
cttggtatcg aaacaatggg tggagtattt acaaaactta tcgatcgcaa cactacaatc   392340
ccaacatcta aatcacaagt cttctcaaca gcagcagaca accaaccagc cgttgatatc   392400
cacgttcttc aaggtgaacg cccaatggca gcagataaca agactcttgg acgcttccaa   392460
ttgactgata tcccagctgc acctcgtgga attcctcaaa tcgaagtaac atttgacatc   392520
gacaagaacg gtatcgtgtc tgttaaggcc aaagaccttg gaactcaaaa agaacaaact   392580
attgtcatcc aatcgaactc aggtttgact gacgaagaaa tcgaccgcat gatgaaagat   392640
gcagaagcaa acgctgaagc cgataagaaa cgtaaagaag aagtagacct tcgtaatgaa   392700
gtagaccaag caatctttgc gactgaaaag acaatcaagg aaactgaagg taaaggcttc   392760
gacgcagaac gtgacgctgc ccaagctgcc cttgatgacc ttaagaaagc tcaagaagac   392820
aacaacttgg acgacatgaa aacaaaactt gaagcattga acgaaaaagc tcaaggactt   392880
gctgttaaac tctacgaaca agccgcagca gcgcaacaag ctcaagaagg agcagaaggc   392940
gcacaagcaa cagggaacgc aggcgatgac gtcgtagacg gagagtttac ggaaaagtaa   393000
gatgagtgta ttggatgaag agtatctaaa aaatacacga aaagtttata atgatttttg   393060
taatcaagct gataactata gaacatcaaa agattttatt gataatattc caatagaata   393120
tttagctaga tatagagaat tatattagct gaacatgata gttgtatcaa aaatgatgaa   393180
gcggtaagga attttgttac ctcagtattg ttgtctgcat ttgtatcggc gatggtacca   393240
gctatgatat cattagaaat acaaacatat aaatttgtaa taccgttcat aattggtatg   393300
atttggacag tagttgtatt tcttatgatc aattggaatt atataggcaa atactaagaa   393360
gagacaaaaa tatataaata tttctgtact tataggatat ttaaaatcaa aataaagtta   393420
atttacttat ttgcagaggt tgcaacccag cctctgtttt tcgataaaaa gggacggaat   393480
ctcatttgtt tgggttttgt ctcatcaata gaaaggaaca aagagtgttc gtaactgaac   393540
acgggtttca gaatttctta ctaaatataa aagaaaggaa ttgaacccga cctaaatggt   393600
ggttcgattc agaacatcaa tagaaaggaa taagggtgtt cgtaactgaa cacgggctat   393660
ggactgtgcc aaaaagatag ttttttctag gacgtaagcg tccgtcgtca aaactcctag   393720
atggctgtgt ccgtttgacg ccctttgtat cttgaattat gaacaatact gaattttatg   393780
atcgtctggg ggtatccaaa aacgcttcgg cagacgaaat caaaaaggct tatcgtaagc   393840
tttccaaaaa atatcaccca gatatcaaca aggagcctgg tgctgaggac aagtacaagg   393900
aagttcaaga agcctatgag actttgagtg acgaccaaaa acgtgctgcc tatgaccagt   393960
atggtgctgc aggcgccaat ggtggttttg gtggagctgg tggtttcggc ggtttcaatg   394020
gggcaggtgg cttcggtggt tttgaggata ttttctcaag tttcttcggc ggaggcggtt   394080
cttcgcgcaa tccaaacgct cctcgccaag gagatgatct ccagtatcgt gtcaatttga   394140
cctttgaaga agctatcttc ggaactgaga aggaagttaa gtatcatcgt gaagctggct   394200
gtcgtacatg taatggatct ggtgctaagc cagggacaag tccagtcact tgtggacgct   394260
gtcatggcgc tggtgtcatt aacgtcgata cgcagactcc tcttggtatg atgcgtcgcc   394320
aagtaacctg tgatgtctgt cacggtcgag gaaaagaaat caaatatcca tgtacaacct   394380
gtcatggaac aggtcatgag aaacaagctc atagcgtaca tgtgaaaatc cctgctggtg   394440
tggaaacagg tcaacaaatt cgcctcgctg gtcaaggtga agcaggcttt aacggtggac   394500
cttatggtga cttgtatgta gtagtttctg tggaagctag cgacaagttt gaacgtgaag   394560
gaacgactat cttctacaat ctcaacctca actttgtcca agcggctctt ggtgatacag   394620
tagatattcc aactgttcac ggtgatgttg aattggttat tccagaggga actcagactg   394680
gtaagaagtt ccgcctacgt agtaaggggg caccgagcct tcgtggcggt gcagttggtg   394740
accaatacgt tactgttaat gtcgtaacac cgacaggctt gaacgaccgc caaaaagtag   394800
ccttgaaaga attcgcggct gctggtgact tgaaagtaaa tccaaagaaa aaaggcttct   394860
ttgaccatat taaagatgcc tttgatggag aataatactc ttcgaaaatc tcttcaaacc   394920
acgtcagcgt tgccttgccg tatatatgtg actgacttcg tcagtcgtat ctacaacctc   394980
aaaacagtgt tttgagcagc ccgtggctag tttcctagtt tgctttttac tttatagatt   395040
ttttaagact ttcctaagta atgacggacg gtagtgacct ccttcgaagt tccataccta   395100
aactttgaac ctaagtttta aagtttccgg acagctgaaa ccaagctgtt tcaggtgttt   395160
tcattacggc agaaagtctt cgatttagtt gtgaaatggt gaatgatact cttcaaaaat   395220
ttcttcaaac cacgtcagcg tcggcttgtc atgggtatgg ttactgactt cgtcagttct   395280
atccacaacc tcaaaacagt gtttgagctg acttcgtcag ttctatccac aaccttaaaa   395340
cggtgttttg agcagtctgt gcctagcttt ctagtttgct ttttgatttt tattgagtat   395400
gaattaccta aattatgatg catagttgat gggatatata taatagattg aaatagaata   395460
tgaacaaatt gataagagga ttttaaagta atctctaaca atgctttaga aactatggtg   395520
tgctattcta aattcaattc actataactt gtttacgttt taaaaaagag ccgtcgggct   395580
ctttttactt atcttcagtt ccctgcattt cttttatcac agctagtcta gtctggatat   395640
ccttttccaa gaccttaaac ttgtaagtca agtcttcttg gtattccttg ataagttctt   395700
tttgctggtt aatgatttgc aggctgtttt ggataatatc cacatcgtcc ttgatagctt   395760
gaacgcggtc agtggtattc aagacttcat ctgtgatggt ttggcgattt tttgtaacca   395820
gataacttcc ggctgcagct cctgcaaata gcagtaggtt ggataatttc atagcaactc   395880
cttaagcgtt tttgatggtt tcagcgactt gagcaagttt gtcaaagtct ggttcgtggg   395940
cgataaaatc aatcttgagg tcatcgtcag cactgtagcg aggcacaagg tgaacgtgag   396000
tatgaaaaac tgtttgacca gcgacttctt cacagttgga aatgatattc ataccagcag   396060
ccttagtgac tttcatgact ttttgagcta cttttggtac ttgggcaaag agttggctgg   396120
cgctcgtagc atccatctcc aaaagattgc gatagtgttc ttttggcacg accaaggtgt   396180
gtcctagtgt tacttgagag atatcaagaa aggcaaggac ctgctcatct tcatatactt   396240
ttgaagcagg aatttcccct gcgatgattt tacaaaaaat gcaatctgac ataaaatcta   396300
cctctactgt actgaatttt gatataatat agctacatta taccagattt ggagaaaata   396360
tgttagaaat taaaaacctg acaggtggct atgttcatgt tcctgttttg aaagatgtgt   396420
cctttactgt tgaaagtggg cagttggtcg gtttgattgg tctcaatggt gctgggaaat   396480
caacgacgat caatgagatt atcggtctgt tggcacctta tagtggctcc atcaatatca   396540
atggcctgac tctgcaagga gatgcgacta gctaccgcaa gcagattggc tacattcctg   396600
agacgcctag tctgtatgag gaattgaccc tcagagagca tatcgaaacg gttgctatgg   396660
cttacggtat tgagcaaaaa gtggctttcg aacgagtaga gcccttgtta aaaatgttcc   396720
gtttggaaca gaaattagac tggttccctg ttcatttttc aaaagggatg aagcagaagg   396780
tcatgattat ctgtgctttt gtggtggatc caagtctttt catcgtggat gagcctttcc   396840
ttggtcttga tccgctggct atttctgatt tgattcagct tttggaagtg gagaagcaaa   396900
agggcaagtc tattctcatg agtacccacg tgctggattc ggcggagaag atgtgtgatg   396960
cctttgtcat tcttcacaag ggagaggtgc gttccaaagg caatctcctg caactacgtg   397020
aagcctttga tatgcctgag gctagtttga atgatattta cttggctctg accaaagagg   397080
aggatctatg aaagacttgt ttttaaagag aaagcaggcc tttcgtaagg agtgtcttgg   397140
ttatctgcgc tatgtgctca atgaccactt tgtcttgttc ctgcttgtcc tgttgggctt   397200
tctagcctac cagtacagtc aactcttaca acattttcct gaaaatcatt ggcctatcct   397260
tttgtttgta ggaattacgt ctgttttact tttactttgg ggaggaactg ccacctatat   397320
ggaggctcca gacaagctct ttctcttagt tggagaagag gaaattaagc tccatctcaa   397380
gcgtcaaact ggcatttccc tagtcttttg gctctttgta cagacccttt tcttgctgtt   397440
atttgcgcct ttatttttag caatgggtta tggcttgcca gtttttctgc tctatgtgct   397500
tttattgggg gtaggaaaat atttccactt ttgtcaaaag gccagcaaat ttttcactga   397560
aactggactg gactgggact atgttatttc tcaagaaagc aagcgtaagc aagtcttgct   397620
tcgtttcttt gccctcttta cgcaggtcaa gggaatttca aacagcgtta agcgtcgtgc   397680
ctatctggac tttattttaa aggctgttca gaaggtgcct gggaagattt ggcaaaatct   397740
ctatctgcgt tcttatctgc gaaatggcga cctctttgct ctcagtcttc gtcttctctt   397800
gctttccttg ctggcgcagg tttttatcga gcaagcttgg attgcgacag cagtggtagt   397860
tctctttaac tacctcttgc tcttccagtt gctggccctc tatcatgcct ttgactacca   397920
gtatttgacc caactctttc cgctggacaa ggggcaaaag gaaaaaggct tacaggaggt   397980
agttcgagga ttgaccagtt ttgttttact tgtggaatta gttgttgggt tgattacctt   398040
ccaagaaaaa ctagcccttc tagccttact aggagctggt ttggttttac tagtcttgta   398100
tttgccttat caggtaaaac gtcagatgca ggactaacat tgctgatacg acactaaaaa   398160
agaagttgag ttcagtctgt ctcaacttct tttttgttac tacaggataa tggttggtcc   398220
gtagagactt atactcttcg aaaatctctt caaaccacgt cagcgtcgtc ttaccgtact   398280
caagtacagc ttgcggctag cttcctagtt tgctctttga ttttcattga gtattaactt   398340
ggtcttgact tggtcaaagt ggaagcggtc ataggcccgc caagcggcgc gagttggagc   398400
atctggatca agagcgctga gtcccatgag aagactggaa gtctggtaaa atttttctag   398460
ttcaatcaag aatcgattat ccactgtttc agccttggct agaaaaccaa gaatagagtt   398520
taattgctcc tgaaagcgga cgtcgtcagc gcttgcctgt ttgcatgctt ggtaggcttt   398580
gtttaagtca gtaatcaaag tatgagctct tttgatgggg tctgtatctg tcatgggaat   398640
gcctccttta atctgggtgc cagtcttact tctggcaact gtgttttgat actgttagtt   398700
tatcactttt aattcttttt ttttattcaa atctttaatt gtcattgaaa tgtcttgaat   398760
tgcgctgagt gaattttatg ataaaatagt tgtaagctca tcatgatgtt gtagaaaata   398820
atccttttag gagttttcaa agactgttta ggattgggtg tgcttgggct agaccttttc   398880
tgttattctt ttcttaggag gagaatccaa tgaaatatat gattattcag acgcagaaaa   398940
cagtctataa agtaaacatc gacgatatct actatatcca aacacatcca actaaagccc   399000
ataccgtaca gattgttaca gaagaagcta gttttaatat gcttcaaaat ttaagtaatc   399060
ttgagaacca atgtggggaa accttgatga gatgtcatcg aaattgtttg gttaatcttg   399120
ataaattaaa atcgattgat tttcaagaaa gaatcctttt tctcggagaa gaaggtcaat   399180
acgctgtcaa gtatgccaga cgtcgctata gagaaattcg tcaaaaatgg ttgaaagagg   399240
gagagtaaga agatgagaat atttgtttta gaggatgatt tttcccaaca gactagaatt   399300
gaaacgacga ttgagaaact tttgaaagca catcatatca ttcctagctc ttttgaggta   399360
tttggcaagc cggaccaact gctggctgaa gtgcatgaga agggggccca tcagctattc   399420
tttttggata ttgagattcg aaatgaagag atgaagggac tggaagtggc tagaaagatt   399480
cgggatcggg atccttatgc cctgattgtc tttgtgacga ctcactcgga gtttatgccc   399540
ctgtcttttc gctaccaagt gtctgctttg gactacattg ataaggcctt gtcagcagag   399600
gagtttgaat ctcggatcga gacagccctc ctctatgcca atagtcaaga tagtaaaagt   399660
ctggcggaag attgctttta ctttaaatca aaatttgccc aatttcagta tccttttaaa   399720
gaggtttact atctcgaaac gtcgcccaga gcccatcgtg ttattctcta taccaagaca   399780
gacaggctgg aatttacagc gagtttagag gaggttttca agcaggagcc ccgtctcttg   399840
cagtgccacc gctcttttct catcaatcct gcaaatgtgg tgcatttgga taagaaagaa   399900
aaactgcttt tctttcccaa tggtggaagt tgtctaatcg cccgttataa ggtcagggaa   399960
gtgtctgagg ccatcaataa attacactga gctaggagaa tttatgaaca ttgcttggat   400020
attgttgtat acacttgtta ctaatggact agaaattgtc atcttcttta aggtggatgg   400080
aattgatctt actttcgaga ggatttttaa ggcctttctt ttgaagatac tgttggcctt   400140
tgtttttgtg atgattagct atatagtagg aaatgtttac ctatcttatt ttatggaacc   400200
cttgtacggc ataggcttat ctttcttatt attgagaggg cttcctaaaa aactcctttt   400260
cttttatggt ctctttccaa tgatattggt gaatctcttt tatagaggag tctcctattt   400320
tgtgcttcca tttttgggac aagggcaagt atatgatggc tactcattta ctgggttatg   400380
tataataatt ttcaatttct tcatttctct agcttttttg aaatggttgg actacgattt   400440
tactagcttg agaaaggaga ttctcgataa agcctttcaa aagtccctga ctcagattaa   400500
ctggataatg ggtggctact atctagtcat ggaaagtctg tctttttttg aatatgaaca   400560
aagtattcaa tcaaagactg ttcgccatct catcctagtc ttttacctac tcttttttat   400620
gggggttatc aagaaattgg atacctattt gaaggaaaaa ctctatgaga gattggaaca   400680
agagcaggcc ctgcgctata gagatatgga acgctatagt cggcatatag aggagcttta   400740
caaggaagta cggagctttc gtcatgatta taccaacctc ttgactagct tacgtctggg   400800
cattgaagag gaggatatgg agcagataaa agaggtctat ggctccgtct taaaggattc   400860
cagtcagaaa ttgcagaaca ataaatatga cctgggcaga ttggtaaata ttcgtgataa   400920
agccctcaaa agtcttctag cagggaaatt tttaaaagcc agagataaga acattgtctt   400980
taatgtcgaa gttcctgagg agattcaggt cgaggggatg agtctacttg attttctaac   401040
cattgtgtct atcctttgtg acaatgctat tgaagccagt gtggaagcta gtcaacctca   401100
tgtttcaatc gcctttttaa aaaatggagc acaggagacc tttatcatcg aaaactccat   401160
caaagaagag ggcatcgata tttctgaaat cttctccttt ggagccagtt ctaaagggga   401220
ggagagagga gttggtctct ataccgtcat gaagattgtg gaaagccatc ctaataccag   401280
tctaaatacc acctgtcaaa atcaagtctt tcgtcaggta cttactgtga tacatacaga   401340
atgatgaaaa ataagaccga gagtacttgt ttctcggtct tattttttta tagttgtatt   401400
ggatgatgaa gttcttatgt gatgtaatga gcatatctat taatgttata taataaatct   401460
tcccacaatc ctccacctgt aatttgattg agttcggtag ttgttagttc ttgaaatgaa   401520
gttaggtttt gtttcttatc catgttatga ttctcctttt tgataagata ataaatagtt   401580
atagagtgtt atctgaaaat taatcagaat gtgttaaaat tttatctttg aaataatcaa   401640
aatatgtttt ctttgtagtt acactagtga cgcgaccttg taagccatat tggatgagtt   401700
tactatcctc gttagatagt tttgcaagag cggttaattt aaagagattt ccttgctctg   401760
ttctggtagg agtttgatca attgtctgaa gttggccgat gatggtggtg ccgtgatttc   401820
caatcttctc cagttttaat cttacagttt gtcctttatc tagtagaggt agatagtcag   401880
aagatacgta gtaagtgatt agtacttctc ttgtatctgt gatgacaggg aatatttgag   401940
caatttctgt accagttgga attctatttt taccttcaaa ttcgctgttc agatgaacga   402000
tacctttact tggggaggtt aaggtattgt tttccaaacg ctgtgtggct tgatctagtt   402060
gtacttttaa ttctgttaat tgattctcca cagttagttg ttgctgtgag gctgtctgta   402120
aaaactgagt gcggagtact tcaattttgg ttgctaaact gttatcataa gttgctacac   402180
ttccgatacc agcttgctga attttgaggc ttgcgataga tgattcaaga cctgcaatac   402240
tttgattaat ttgagataaa aatggctcct ctgcagttcc ttgtgtttgt ccttgtgagg   402300
ctacaagata acgattcaaa attgactggt gcggattgcc agttggtaag cgtgctctgt   402360
tatttatgat agcatctctc aactcttgat attctccaat ttgttgttga acttttgtaa   402420
tttcttgttc aatagctgat gaactgctat tggaaagatt agcttgattt gaaacttcgg   402480
tgttagtctt tgtgataccc agttcaatat catgggattg tttagtaaaa ttcataaagg   402540
tattatggta gccaaattca tcctcgccag aaaaaagatc agtcgctttt tctaagcttt   402600
gtttcaaaat tccaagtcct tctttttgct tctcaagtct ttgtaattga gttgctaagg   402660
cagttttctg actttcttcc attgtttcag agtatttgat gagtaagtcc cctttttcaa   402720
ctacttgatt tgccactaaa tgattagcta ggataggatt atcactggtt gactgaatgg   402780
aggcaatgac acttgtaggg gcgatttctc cttgggaagt aacagtaatt tcttttgtgg   402840
caacaaggga gaaaatcaag atgaaagtaa atagtaatga aagaggtata attaacactg   402900
tcgcatagtt atggtaacgt ctctgataaa actcgacgct tctaaaaaga ttaggattca   402960
tgacattctc cttatttatt gaatagatga tggtagaaac cttgcgcctg cattaactct   403020
tggtgactac caacttcaat gattttcccc tggtcaagaa caatgacacg gttggttcgt   403080
tcggctatac tgagacgatg ggctacaaag agaatggttt tatcagttag agacataaga   403140
ttatctataa cctttttctc agtcaagaca tcaagaccgc tagtagcttc atctagtatt   403200
aaaacaggag atttagttaa aagagcacga gcgagagcga ttcgttgctt ctgtcctcct   403260
gatagaccag ctccatcaga gagctgagtt tgatagccca taggcattct ttcaatgtct   403320
tgacggattt cagctacttc acaagctttt agaatatctt cttgactaat catatgatta   403380
ccgcccaagg ttaagttttc caaaatagag ccattaaaga tataggcttg ttggggtagg   403440
taattaatat gacggcgcaa gactttttta tcaatgtttt taatatcctg atgattgatg   403500
gaaatatgcc ctttgtaggg ttcaaagaaa ttgacaatca ttttggctaa agttgtttta   403560
ccagaaccac taactccaac taggctaacc ttatctcctt gtttaatcgt gagattaata   403620
tctgttaagg tatctcatcc aaaaccatac ttataagaaa ggtcatcaaa ttcaatatcg   403680
cccatcaaaa aatgtgaatg aacagggttt tcttgaactt gaaattcaga ttcgactaga   403740
tagacttcgt tcaaacggtt attagcgacc ttcgcagatt ggagtttggt ttggaggttg   403800
ataatatttt ccataggagt tgtaaagtaa gaaaaaagtg tgttaaaggt aatcagctga   403860
ccgatagaaa ttttacttga catgactaat tgagcgccaa accataggat aaggatattc   403920
agaactaatt ttgttccctg ctttaaactc gtttgtaaaa tagaatattt actgagctta   403980
aaggattttt ccaaataatc tacaaattcg ctgtctatat tttgatagcg attttcttca   404040
ctcgtgagcg actttatagt ttcaatcccg ttgatatctt cgataatggc agagctaacc   404100
atagaattac tttgcatgac atcatggttc attttttcga aaggtttcat aaaagaaaag   404160
atgatgaaca tgtatatagg aatggaaata agagaaagaa ggaagagatt agggttttgt   404220
gccagtaaga cgcctcctac aagaatcaga atagaaacat ccagaaaaag agaaagaatg   404280
gtagaagcca aggcatctat aatagagtta gcatctgtga atcgtgaaat gatttctcct   404340
gtacgacgtg tcgcaaagaa agacatggga agttcaaaaa tatggcgaat ataggataaa   404400
atcacatcaa tacttaatct ctgactcaga acggttagga gataatctct ggagaagctc   404460
atgacttgtt ggaggatata ggtgataacc agaccaactg agatgattcc taaagttgat   404520
ttcatctgat ttggaatgta ttcatccaag attccttgga gatagtaaga accacctata   404580
ttgataatag tgaccaataa gcttgagaga acaatgtaag caatgagaga tttttgtttg   404640
aaaatcagag gaaggaagct tgcttagtag accattcttt ttatctttat ggggttgata   404700
gctgggtttg gtagctagaa aaatagctac tccagtccat tcatagaaaa agcgttcttt   404760
tgacatttta gtgattttta cagaagggtc aggatcacca ataatcagat agtctttctt   404820
tgtttgatag acaacatagt aatgttggag ttttccttct ttgttaacgt gaacgataaa   404880
tggatagggg acatcactca tgtcaaagag cgttttatct gcttgaacag gtcttgtttc   404940
aaagcccatt tcatcagcgg cttttacaat gccaagagca gtcgtccctt ctttattggt   405000
ctttgcaagt tctctcaagt gagctagaga aaaatctgaa ccatagaatt tagcaatcga   405060
ggctaaggca gcgacaccac agtctctcgc atctatttga ggaacaaatg tacgtttata   405120
agaagtcatt ggcaattcct ttcatatagt ggataggtct attatgtcat aaaactaagt   405180
tcatatttta tgaaatcttg aatagtcatt aaaacttcct gaatggtaaa aaagtgatta   405240
gaaattattt tttttaaaca tttagaggtg gcttgaaata aaaaagctaa ttcaagacgt   405300
ttcgatgaca attcaagatc tggatgaaaa attttaaaaa acgatgatat actaaactta   405360
tcaaagttac aacaagacaa aaataaaaaa agaaaaaagg agtatttgtc atgaatacaa   405420
aaatgatgga acaattttct gttatggata atgaagaact cgaaatagtt agtggaggaa   405480
gaggcaattt aggatctgca atcggtggtt gtattggagc agtactatta gctgctgcga   405540
ctggtccgat aactggggga gcagcaacac ttatttgtgt aggttcagga attatgtcct   405600
ctttgtaaga ttatgattct taaatatagt attattatcg ctattaattt actgtcttat   405660
ttacttactt acaaaatatc aaagttatct aagaatgatg agaataagat agttagcaaa   405720
attttaatta tattatcaat cgtttatgta atcgttgatg ctttacttag ttgatggatt   405780
ggtaggaata aaaaacttaa ctataaacta ttatttacta atattttttg ctttctgcaa   405840
gttaataaat agtatagtaa aactttttat tgcaaggaga ataacgaaat taagatattt   405900
tagatactca agattattga aatcttagac taaaaaatag gtactgctac ctttaagaag   405960
atagtagacg tatatacttt tttaagaaaa tcaaaaagat actataaaaa atctatttgt   406020
ttattgaatt taagactttg gtaacaaatt gaaaataaaa aggaggtatt catcatgaat   406080
acaaaaatgt tgtcacagtt agaggttatg gatactgaaa tgcttgcgaa agttgaaggg   406140
gggtatagct ccactgattg tcaaaatgca ctgattacag gagtcactac gggaattata   406200
actggtggaa ctggagcagg tttggccact ttaggagtag ctggacttgc tggtgcattt   406260
gttggagcac acattggtgc aattgggggt ggattaacat gcttaggagg tatggttggt   406320
gataaattgg gactaagttg gtaagactta tagtaaaatt atgaggattc tattctgatt   406380
tattttagtt ttttaaaaaa ggagtatttg tcatggatac aaaaatgatg tcacaatttt   406440
ctgttatgga tactgaaatg cttgcttgcg ttgaaggtgg cggatgcaat tggggagatt   406500
ttgccaaagc aggtgttgga ggaggagcag caagaggtct tcaactaggc attaaaacag   406560
gaacatggca aggtgcagca actggtgctg cgggtggagc tatacttgga ggtgtagcct   406620
atgcagcaac atgttggtgg taattatgga ttttaaaagt tttattattg gtttagtagt   406680
tggtatattt ggtccttata tggatgactt aattagaaaa atattttcaa aatcttccaa   406740
aaaggatacg gatagtactc tctaaaaaat aaatttctcc cctgtatttg ctagcttaat   406800
ttacagggga gtttctttaa tattgtttcg cctgtcaaaa tgatatgtga tagcaggatg   406860
aaaagtctac aaacaagttg gtatcaatac aatataaaga ggaaagtatg tttttcatgc   406920
ttgctttttt aatttttaca attcaagagg ttttgatgac catttatgat ttgagtgatc   406980
caaggtcaaa ataagtgcta tactagcagt gtaaatgttc ttgctcaact aagataaatc   407040
gcacatttag gaggaaatct tatgaagaaa aaaatactga ttattttcgt tctgtatcta   407100
atcatgtcca tctttctata tccgcttagg gagagtgctt ggtatcagct attttatacc   407160
atagcctatg tgattgcagt tatgatctat tttgctatca ataaaaagaa aggagaaaag   407220
aaatgaaaac ttttcttgct aaaaaacgga acatcttcct tgcgagattg ttcttaggtc   407280
agttgccctt gcttgtttct acttatctat ttctatctcg tcagttttta aatttttccg   407340
tagttttcca atttctttta gtagttatta acttggcttc tattttggtt actgtttatc   407400
tcactaggga aatgaggata agagagtttg aagatgatga tttggttagt cctagaacca   407460
atcaacttat gttcatcggc ttgacaggtt ttatgtctat tatttgtttg tatagaggta   407520
tcacagcagg agaatcctac caacaaataa tcgcttatat tggcgctgtt ctctgcttaa   407580
tcatcatgct tctgctcatg tggggcttga agtattataa aaagtagagc ttaatgaagt   407640
ataaaagaaa agggtaagtg tttttgcaat acttaccctt ttataataga ttccctgcga   407700
aacaaaatat ggtatagtat agtagattga aactagaata gtacgcctct acttctaaaa   407760
cattgttaga aatcgatttg actgtcctga tcgatttatc ctgttcttat ttcattttac   407820
tatagttcta tgaattatga agcaagtaaa caactaactg atgcacgatt taagcgtctt   407880
gttggtgttc agcgcacgac ttttgaagag atgctagctg tattaaaaac agcttatcaa   407940
cttaaacacg caaaaggtgg acgaaaacct aaattaagcc tagaagacct tcttatggcc   408000
actcttcaat atgtgcgaga ataccgcact tatgaagaaa ttgcggctga ttttggtgtt   408060
cacgaaagca acttactccg tcggagccaa tgggttgaag taactcttgt tcaaagtggt   408120
gttacgattt caagaactcc tctcagttct gaggacacgg taatgattga tgcgacggaa   408180
gtaaaaatca atcgccctaa aaaaagaatt agcgaatgat tctggtaaaa agaaatttca   408240
cgctatgaag actcaagcga ttgtcacaag tcaagggaga attgtttctt tggatatcac   408300
tgtgaactat tgtcatgata tgaagttgtt caaaatgagt cgcagaaata tcggacaagc   408360
tggtaaaatc ttggctgaca gtggttatca agggctcatg aagatatatc ctcaagcaca   408420
aacttcacgt aaatccagca aactcaaacc gctaacagtt gaagataaag cctgtaacca   408480
tgcgctatct aaggagagaa gcaaggttga gaacatcttt gccaaagtaa aaacgtttaa   408540
aatgttttca acaacctatc gaagtcatcg taaacgcttc ggattacgaa tgaatttgag   408600
tgctggtatt atcaatcatg aactaggatt ctagttttgc aggaagtcta atgtaatttt   408660
tgcaattcaa gacgtttcga tgactattca aaatctggat gaaaaatttt aaaaaacgat   408720
gatatactaa acttgtcaaa gttacaacaa gacaaaaatt aaaaataaaa aagagtattt   408780
gtcatggata caaaaattat ggaacaattt catgaaatgg atataactat gttatctagt   408840
attgaaggag gcaagaataa ttggcaaact aatgtcttag aaggtggtgg tgctgctttt   408900
ggtggctggg ggctagggac agctatttgt gctgcgagtg gtgttggagc accatttatg   408960
ggagcatgtg gatacatagg agctaaattt ggtgtggatc tttgggcagg agtaacaggg   409020
gcaacgggtg gattttaata aaaggagact tgtatgaata cttattgtaa tataaatgaa   409080
acaatgctga gtgaggttta tggaggtaat tccggaggag cagctgtagt tgctgcttta   409140
ggttgtgcag cgggtggagt gaaatatggg agacttctag gaccatgggg cgctgcaata   409200
ggaggaattg gaggagcagt ggtttgtgga tatttagcct ataccgctac atcataaaaa   409260
tgaaagctaa attttatgaa ggctatattc tttattattc tcttcgcttt tcaaacctat   409320
cttatttatc tatccataag tatctccgat aaaaaacaaa agactattga attaacatca   409380
ttgaattgtt ttgtcatatt atttctaatc tatgataaat taatttttct ctttattgcc   409440
tatgtttttt tgataatttt tatattaaac ttgttccgta actgaaaagt gatacactat   409500
atggatacaa aaatgatgtc acaatttgca gttatggata atgaaatgct tgcttgcgtt   409560
gaaggtggag atattgattg gggaagaaaa attagttgtg cagcaggggt tgcatatggc   409620
gcaattgatg ggtgtgcaac aacggtttga catttctatt gggaccattt gctataggaa   409680
taggtgtaac tggtgctgca ggtggagcta tacttggagg tgtagcctat gcagcaatat   409740
gttggtggta attatggatt ttaaaagttt tattattggt ttagtagttg gtatatttgg   409800
tccttatatg gatgacttaa ttagaaaaat attttcaaaa tcttccaaaa aggatacgga   409860
tagtactctc taaaaaataa atttctcccc tgtatttgct agcttaattt acaggggagt   409920
ttctttaata ttgtttcgcc tgtcaaaatg atatgtgata gcaggatgaa aagtctacaa   409980
acaagttggt atcaatacaa tataaagagg aaagtatgtt tttaatgctt actttttaaa   410040
ttttttaaca attcaagatg tttcgatgac aattcaagat ttggatgaaa aattttaaaa   410100
aacaatgata tactaaactt gtcaaagttg caacgggtgc tgctacatta tgttaaaaat   410160
cgctcttgat tgataagctg gatttgttag gaaaggagta aataattatg gataagaaaa   410220
agatagtttc gactataata tgtatagtat ttcttgtagt gtcagtagat aattttttta   410280
gagacttaac cccgttactg ttcattttaa atattattgg cctgtcttgc ttttcagtgc   410340
taacatacat taaaataaaa gagatactct taaatataag taaatgatga tttggttagt   410400
cctagaacca atcaacttat gtttatcggc ttggcagatt ttatgtttgt catttgtttg   410460
tatagaggta tttcagaaac agaattctat caacaactaa tcgcttatat aggtgtattc   410520
tctgcttgtt tatcacgctt ctgctcatgt ggggcttgaa gtattataaa aagtagcttt   410580
ctatcctttt ctgacaggat atttgagtag aaggctctat taaattgtta gtgaaataaa   410640
tgaatggagg tatttaatat gaaatacaga ttattttttg ttattttctt gagtagtgtg   410700
ttggatattc ttttagggac atttttacaa atctctatcg tatctattgg gtggcttgtt   410760
ctttacagtg gtttgtttga agcaggagtt ttccttcttg ctaataaagg ggtggcggta   410820
aaaatcaagg aagtagatat tcgaaatcgc tttaaattta tttttggaaa aaccttatgg   410880
tttcaaattc ttttgctcat ctttttgata atcaaacttt atcttggttt ggatgcgagg   410940
ttgattttat tctatggaca tattttcatt gtctttaatg ccttaatgta tctattatct   411000
agtagtcagg ttagccttaa aaaaaacaaa ctgtcttctt aatcttacag cagtagagcc   411060
tgacaaggtg aggtcatagt agggaggatt tctatgaaaa agtatcaact tctattcaaa   411120
ataagtgcag tcttctctta cttatttttc gtatttagtc tttctcagct gacgcttatc   411180
gtccaaaact attggcaatt ttcttctcag ataggcaatt tattctggat tcaaaatatc   411240
ttgagtttac tttttattgg agtcatgatt gtggttcttg ttaagacagg ccatggttat   411300
ctcttccgca ttccaagaaa aaaatggctt tggtattcga ttttgacagt attagtgcta   411360
gtgttccaga tctcttttaa cgttcagaca gctaaacatg ttcagtcaac tgcggaaggt   411420
tgggctgtat tgattggtta tagtgggact aactttgcag agctaggtat ttatatagcc   411480
ctgttctttc tggttccact gatggaagaa ttgatttata gaggattact gcaacatgct   411540
ttctttaagc attcgcgatt tggtcttgat ttgcttcttc cttctatttt atttgctctc   411600
cctcattttt caagcctgcc tagtctgtta gatatcttcg tctttgcaac agttggaatc   411660
atctttgctg gtttgacccg ctataccaag agcatttatc catcctatgc ggtgcatgtg   411720
atcaataata ttgtagcgac cttcccgttt ttgctcactt ttctacatag ggtcttgggg   411780
taaaaaaaca aaaggcttgc ttttcagcca tagaggaggt catcatgtat aaacacttat   411840
ttttcctaga ttccaaaact ttagatcggt tgacacccta tattctagtc ttggcttctg   411900
acaccattgc ttttaatgtt tttgtgctaa cctttgtatc tgcggtggtt tttaatttcc   411960
taaattccat gctagcttta atggctatat tcataggggc tggctatgtg gtcggatttt   412020
ggttactaat actcaatgaa aatcaaagag caaactagga aactagccgc aggctgtact   412080
tgagtacggc aaggcgacgt tgacgtggtt tgaatttgat tttcgaagag tataaaatgg   412140
tttgttttgg aaaggctaga actaaagaat gacgtgtagg aagtctgttt gttgaggagg   412200
ataattttat ggagtttttt gataaatttc atgccttgtg ttttggattt ttagtactaa   412260
taattgtcat tacagttcct tatacgatta accatggggg tttttttcaa aatgaatctg   412320
cattgattct tgtaagtctt cttgtaacct cgctgagtgt tgcttatgct agaaagtttg   412380
aaatgatttc ttttgggatg ttaagcaaga aacaactttt gcttttcatt gcaatctttc   412440
ttctaagtgt acttgagacg ctggtttata ttcatttctt cgctgtttct tctggctcag   412500
gggtccaaca cttggcggaa gtcagcagag gaatttccct gtctttgatt ttgactacct   412560
cagtttttgg ccccatccag gaggaactca ttttcagagg acttcttcaa ggtgcggttt   412620
ttgacaattc ttggttaggg cttgtgctaa cttcctctct cttttctttc atgcatggac   412680
cttctaatgt cccttcgttt attttttatc tacttggggg tttgttgctg ggctttgctt   412740
ataaaaagag tcaaaaccta tgggtttcta ctctagtcca tatgctttac aacagttggc   412800
cactcttata ttatttataa aaattatgaa aaggtaagca gaagacggtg cttacctttt   412860
tcaagctata atgataccca agccaatcca gaggcttttc tttgagaatc gggttagagt   412920
ggttgacgaa taggccaaaa actagtagaa tagtaaggaa actttatacg gaggaaagaa   412980
atggatttgg gtgataatga gctaacactg actcccatac ctgggaaaag tggcaaggct   413040
tatatgggta gctatcctga tgggaagcgc atctttgtaa aaatgaacac ctctccaatc   413100
ctacctggtc tagctagaga acaaattgct ccacaattat tatggagtcg tcgtttggca   413160
gatgggcgtg atatgtgtgc tcaagaatgg ttgacaggca agatattgac cccctatgat   413220
atgaatcgta agcaaatcgt caatatttta acccgtcttc atcgctcacg tccgttgatg   413280
acacaattga gtcgtttggg ctatgccatg gaaacacctg tagatttact acagtcttgg   413340
caggaaacgg ctccagatgc tttgcgtaaa aatcatttta tcagtgaagt gatggctgat   413400
ttacgtcaga ctattccagg atttagagag gaccatgcga ccattgtcca tggagatgta   413460
cgacatagta attggattga gacagatagt ggcttgattt atttagtaga ttgggattcg   413520
gttcgcttga ccgatcgcat gtttgatgtg gcccatatgc tctgccatta tatttcagaa   413580
catcagtgga aggaatggtt gacctactac ggttacaagt acaatcaaac ggtattaagt   413640
aaattgtatt ggtatggtca attgtcttat ttgagtcaga tttccaagta ttatatgaac   413700
caagatttag aaaatgtcaa tcgggagatt catggtttgc gtcatttccg agacaagtat   413760
ggaaagagaa gatgagagtt agaaatcgta aaggggcaac agaattacta gaggcaaatc   413820
cccagtatgt ggtcctcaat cccttggaag ccaaggcaaa atggcgggac ttgtttggca   413880
atgataatcc cattcatgtg gaagttggaa gtggaaaggg tgcctttgtt tcaggtatgg   413940
ccaagcaaaa ccctgacatc aactatatcg ggattgatat tcaaaagtct gttttgagct   414000
acgctttgga caaggtgctt gaagttggag tgcctaacat caagctcttg tgggtagatg   414060
gttctgactt aactgactac tttgaagacg gtgagattga tcgcttgtat ctgaactttt   414120
cagatccatg gccgaaaaaa cgccatgaaa agcgtcgttt gacctacaag accttcttgg   414180
ataccttcaa acgtatcttg cctgaaaatg gagaaattca tttcaagacg gataaccgtg   414240
gcttgtttga gtacagttta gtgagctttt ctcaatatgg catgaaactc aatggtgtct   414300
ggttagattt gcatgccagt gattttgaag gcaatgtcat gacagaatac gagcaaaaat   414360
tctcaaacaa ggggcaagtt atctaccgag ttgaggcaga attttaagag ataacctaaa   414420
attaggctgt acaagtgctt ttgctttaca taagttggca aacgtgctat actgatagta   414480
agaatatgaa aagtgaggcg gggaaatatc ttcgcctctt gcttatgagg aggtggacgc   414540
aatcgcaaca atcgtagaat tagtcagaga agttgtagaa cctgtcatag aagctccttt   414600
tgaactcgtg gatatcgagt atggaaagat tggcagtgac atgattctca gtatttttgt   414660
agataaaccc gaagaattac cttgaacgac acggcagact tgacagaaat tatcagtcct   414720
gtcctagaca ccatcaagcc agatcccttc ccagaacaat atttcctaga aattaccagt   414780
ccaggtttgg aacgtccttt gaaaaccaag gatgccgtcg ctggagcggt tggaaaatac   414840
atccatgtcg ggctctacca agccatcgat aagcaaaagg tctttgaagg aaccttgttg   414900
gccttcgaag aggacgagtt gactatggaa tatatggaca agacgcgtaa gaaaaccgtc   414960
caaattccat acagtttagt atcaaaagca cgtttagcag ttaaattata gaaaaagaaa   415020
ggatagcttt tgaggattca aaagtgaaga aaacatgagt aaagaaatgc tagaggcctt   415080
ccgcattttg gaagaagaca agggaatcaa aaaagaagat atcatcgacg cagtagtaga   415140
gtcgcttcgt tccgcttatc gcagacgcta tggtcagtca gacagcgtag ctattgactt   415200
caacgaaaaa acaggtgact ttacagttta tactgtccgt gaagttgttg atgaagtatt   415260
tgatagccgt ttggaaatca gcttgaaaga tgctcttgcc attaattcag cttatgaact   415320
tggagacaaa atcaagtttg aagaagcacc agctgagttt ggtcgtgtag cagcccaatc   415380
tgccaaacaa accatcatgg aaaaaatgcg caagcaaaca cgtgccatca cttacaatac   415440
ttacaaagaa catgagcaag aaatcatgtc tggtacagta gaacgctttg acaaccgctt   415500
tatctatgtc aaccttggta gcatcgaagc ccaattgtca aaacaagacc aaattcctgg   415560
agaagttttt gcttctcatg atcgtatcga agtttatgtt tacaaggttg aagacaaccc   415620
tcgtggtgtg aacgtctttg ttagccgtag tcatccagaa atgatcaaac gtttaatgga   415680
gcaagaaatt ccagaagttt atgatggaac tgttgaaatc atgagcgtgg ctcgtgaagc   415740
aggtgaccgt acgaaggttg ctgttcgtag ccacaatcca aacgtggatg ctatcggtac   415800
aatcgttgga cgtggtggtg ctaatatcaa gaagattact agcaaattcc acccagctcg   415860
ttacgatgct aaaaatgacc gcatggtacc aatcgaagaa aatatcgatg ttatcgagtg   415920
ggtagcagat ccagctgaat ttatctacaa tgccatcgct cctgctgagg ttgaccaagt   415980
tatctttgat gaaaacgaca gcaaacgtgc cttggtggtt gttccagata acaagctttc   416040
tcttgccatt ggtcgtcgtg gacaaaacgt gcgcttggcg gctcacttga ctggttaccg   416100
tatcgatatc aagtctgcta gcgaatttga agccatggaa gacgctgctt cagtagagtt   416160
ggaagtagaa aacgatactg tagaagaata aaagctgcta gaggagggaa agatgaaaac   416220
aagaaaaatc cctttgcgca agtctgttgt gtctaacgaa gtgattgata agcgtgattt   416280
gctccgcatt gtcaagaaca aggaaggaca agtctttatt gatcctacgg gcaaggccaa   416340
tggccgcggc gcttatatca aactagacaa tgcagaagcc ctagaggcga aaaagaagaa   416400
ggtctttaac cgcagcttta gcatggaagt ggaagaaagc ttttatgacg agttgatcgc   416460
ttatgtggat cacaaagtga aaagaagaga gttgggactt gaataagcaa aagataagta   416520
atctcttggg gcttgctcag cgagcagggc gcatcatatc gggtgaagaa ttggtggtca   416580
aggccattca agacggcaag gccaagttgg tctttctagc tcatgatgct ggacccaatc   416640
tgaccaagaa gattcaagat aaaagtcatt attatcaagt agaaattgta accgtgtttt   416700
caacactgga attaagcata gcagtcggga aatcgagaaa ggttttggct gtaacagatg   416760
ctggatttac aaagaaaatg aggtctctta tggaatagaa gaggaggaca tgatttgtct   416820
aagaaaagat tgtacgaaat cgcaaaagaa cttggaaaag aaagtaaaga agttgtagcg   416880
cgtgcaaaag agttgggctt ggatgtgaaa agccactcat caagtgtgga agaagctgtc   416940
gctgcaaaaa ttgctgccag ctttaagcct gcagctgctc cgaaagtaga agcaaaacct   417000
gcagccccaa aagtaagtgc agaaaagaaa gccgaaaaat ctgagccagc taaaccagct   417060
gtagctaagg aagaggcaaa acctgcagcc ccaaaagcaa gtgcagaaaa gaaagccgaa   417120
aagtctgaac cagtaaaacc agctgtagcc aaggaagagg caaaaccagc tgagccagtc   417180
actccgaaaa cagaaaaagt agcggctaaa ccgcaaagtc gtaatttcaa ggctgagcgt   417240
gaagcacgtg ctaaagagca ggcagagcga cgcaagcaaa ataagggcaa taaccgtgac   417300
caacaacaaa acggaaaccg tcagaaaaac gacggccgta atggtggaaa acaaggtcaa   417360
agcaaccgcg acaatcgtcg ctttaatgac caagctaaga agcagcaagg tcagcaaaaa   417420
cgtagaaatg agcgccgtca gcaagaggat aaacgttcaa atcaagcggc tccacgtatt   417480
gactttaaag cccgtgcagc agccctaaaa gcagagcaaa atgcagagta cgctcgttca   417540
agtgaggaac gcttcaagca gtatcaggct gctaaagaag ccttggctca agctaacaaa   417600
cgcaaggaac cagaggaaat ctttgaagaa gcggctaagt tagctgaaca agcacagcaa   417660
gttcaagcag tggttgaagt cgtccctgag aaaaaagaac ctgcagtgga tacacgtcgt   417720
aaaaaacaag ctcgaccaga caaaaatcgt gacgattatg atcatgaaga agatggtcct   417780
agaaaacaac aaaagaatcg aagtagtcaa aatcaagtga gaaatcaaaa gaatagtaac   417840
tggaataaca acaaaaagaa caaaaaaggc aataacaaga acaaccgtaa tcagactcca   417900
aaacctgtta cggagcgtaa attccatgaa ttgccaacag aatttgaata tacagatggt   417960
atgaccgttg cggaaatcgc aaaacgtatc aaacgtgaac cagctgaaat tgttaagaaa   418020
cttttcatga tgggtgtcat ggccacacaa aaccaatcct tggatgggga aacaattgaa   418080
ctcctcatgg tggattacgg tatcgaagcc aaacaaaagg ttgaagtgga taatgctgac   418140
atcgaacgtt tctttgtcga agatggttat ctcaatgaag atgaattggt tgagcgtcca   418200
ccagttgtta ctatcatggg acacgttgac cacggtaaaa caaccctttt ggatactctt   418260
cgtaactcac gtgttgcgac aggtgaagca ggtggtatta ctcagcatat cggtgcctac   418320
caaatcgtgg aaaatggtaa gaagattacc ttccttgata caccaggaca cgcggccttt   418380
acatcaatgc gtgcgcgtgg tgcttctgtt accgatatta cgatcttggt cgtagcggca   418440
gatgacgggg ttatgcctca gactattgaa gccatcaacc actcaaaagc agctaacgtt   418500
ccaatcatcg tagctattaa caagattgat aaaccaggtg ctaacccaga acgcgttatc   418560
ggtgaattgg cagagcatgg tgtgatgtca actgcttggg gtggagattc tgaatttgtt   418620
gaaatttcgg ctaaattcaa ccaaaatatc gaagaattgt tggaaacagt ccttcttgtg   418680
gctgaaatcc aagaactcaa agcagaccca acagttcgtg cgatcggtac ggttatcgaa   418740
gcgcgcttgg ataaaggaaa aggtgcggtc gcaacccttc ttgtacaaca aggtaccttg   418800
aatgttcaag acccaatcgt tgtcggaaat accttcggtc gtgtccgtgc tatgaccaac   418860
gaccttggtc gtcgtgttaa agttgctgga ccatcaacac cagtctctat cacaggtttg   418920
aacgaagcac cgatggcggg tgaccacttt gccgtttacg aggatgaaaa atctgcgcgt   418980
gcagcaggtg aagagcgtgc caaacgtgcc ctcatgaaac aacgtcaagc tacccaacgt   419040
gttagccttg aaaacctctt tgataccctt aaagctgggg aactcaaatc tgttaatgtt   419100
atcatcaagg ctgatgtaca aggttctgtt gaagcccttt ctgcctcact tcaaaagatt   419160
gacgtggaag gtgtcaaagt gactatcgtc cactcagcgg tcggtgctat caacgaatca   419220
gacgtgaccc ttgccgaagc ttcaaatgcc tttatcgttg gtttcaacgt acgccctaca   419280
ccacaagctc gtcaacaagc agaagctgac gatgtggaaa tccgtcttca cagcattatc   419340
tacaaggtta tcgaagagat ggaagaagct atgaaaggga tgcttgatcc agaatttgaa   419400
gaaaaagtta ttggtgaagc ggttatccgt gaaaccttca aggtgtctaa agtgggaact   419460
atcggtggat ttatggttat caacggtaag gttgcccgtg actctaaagt ccgtgttatc   419520
cgtgatggtg tcgttatcta tgatggtgaa ctcgcaagct tgaaacacta taaagacgac   419580
gtgaaagaag tgacaaacgg tcgtgaaggt ggattgatga tcgacggcta caatgatatt   419640
aagatggatg atgtgattga ggcgtatgtc atggaagaaa tcaagagata agattttttg   419700
ctcctttctt aggtggtgag ggacgcaagc aaaccgatgg tttcattgct tatttttgag   419760
cctagggtct caaaaatccc ctgtgatggg actgataaat cagttccatc actttcacca   419820
cggcgaaaga agcagatgac ttcaaattga acttcgtttc aatttaaact gaaaatcaag   419880
aagtttaaaa tagctaggtc tgctggccta gcttttggtt caaagtagag aaaggaatat   419940
catggcaaat catttccgta cagatcgtgt gggcatggaa atcaagcgtg aagtcaatga   420000
gattttgcaa aagaaagtcc gtgatccacg tgtccaaggt gtgaccatca tagatgttca   420060
gatgctgggt gacttgtctg ttgccaaggt ttattacacc attttgagta accttgcttc   420120
ggataaccaa aaagcccaaa tcgggcttga aaaagcaact ggtaccatca aacgtgaact   420180
tggtcgcaat ttgaaattgt acaaaatccc agatttgacc ttcgtcaaag acgagtccat   420240
cgagtatgga aacaagattg acgagatgct acgcaatctg gataagaact aaagaagagg   420300
ggttgcccct cttttttggt ggaggaaaat aggttgaatt tgaaatggaa aaatattctt   420360
ttataataga ttgaaactag aatagtacgc ctctacttct aaaatattgt tagaaatcga   420420
tttgactgtc ctgatcgatt tgtcctgttc ttgtttcatt ttaatataaa aaagggattc   420480
tgtatttttt aatgttatct aattagaaaa tgcttttttt gtaggaaata taatatgata   420540
aggtgcaaaa aagaaataag gagtttgtat atggctgaac aagacttagc tatgcaagta   420600
ttgcaacaag tggtgaaact acctgttgtt aaggttgatc gttcgaaatt tttagtggat   420660
aagttttcca aagaattgga tccaaaagat attcctacct tattggaaca aggtccaacg   420720
actcttctat ctcaagaaat attagatcgt gtagctaatg cttgtattcg ggacaatgta   420780
ttattagcga gtgggacttc tgttttggca ggattacctg gagggcttgc tatggcaatt   420840
accattccag ctgatgtggc tcaattttat gctttctctc tgaaattggc tcaagaatta   420900
ggttatattt atggttatga ggatctttgg gcttcacgag aggagttgag tgaagatgct   420960
caaaataccc tcttgcttta tctaggcgta atgttagggg tgaatggaac cgctgctttg   421020
ctacgtgttg gtagtataac aattgccaaa caggtaatga aaatagtgcc taataaagct   421080
ttaacaaaga cgctttggta ccctattttg aaaaaagtct taaaaatatt tggtgtgaat   421140
cttaccaagg gagggttggc caaaggaatg gggaaattta ttcctatctt gggtggtatc   421200
atttcaggtg gtttaacctt tgcaactatg aaaccaatgg gggaaagctt gcagaaagaa   421260
ttatccaagc tagtcaacta tagtgaagtt caatatcaag aagatgttga aacaatccga   421320
aaagaggctg aaatcatcaa aggagagtaa tatgaatcct atcaaagctt ttgctaaaat   421380
ttatggtaat tactttttga ccgtgcaagg tgtaaaagtg atgaaaacga taaagaaagc   421440
tgaccatgtc gttgttggtc tggggaaact ttttattgcc gacaagttaa tggatacggc   421500
tcggtggctc attaagccag aggagagaga atgaaatttt tttggtcttc ttgctattct   421560
ttttatcaaa ccgattattg ggattgtgaa attcttttgg atgatcatct cttttgcagt   421620
ccaattgctg ttttacaaga tagtgtttaa gatattggat tggctcttta aacttatcta   421680
gatggtaatc caagttgcag agaactagca ggaactccac tgctagtttt ttattctctt   421740
tccatatggt ataatataag cagtaaaatc attttatact cttcgaaaat ctcttcaaac   421800
cacgtcagct tcaccttgca gtatatatgt tactgacttc gtcagttcta tccacaacct   421860
caaaacggtg ttttgagctg acttcgtcag ttctatctac aacctcaaaa cactgttttg   421920
agcaacctgc ggctagcttc ctagtttgct ctttgatttt cattgagtat tagaacatac   421980
aatggaggtc gtcatggaca atatcatcga tgtgtcaatt cctgttgcag aagtggtgga   422040
caagcatcca gaagtcttgg aaattctagt ggagttgggt tttaaacccc ttgccaatcc   422100
cttaatgcgc aatacagttg gtcgtaaagt atcacttaaa cagggttcta agctagcagg   422160
aactcctatg gacaagattg tacgcacact ggaagcgaat ggctacgaag tgattggatt   422220
agactaatga cagatgaacg gattcatatc ctacgggata ttttgttaga attgcacaat   422280
ggcgcctctc ctgagtcggt tcaagatcgc tttgatgcga cctttacggg cgtgtcagcc   422340
atcgagattt cccttatgga gcacgagctg atgaactcgg attcgggcgt cacttttgaa   422400
gatgttatgg aactctgtga tgtccatgcc aatcttttta aaaatgctat caaaggtgtc   422460
gaagtttcag atactgagca tccaggtcac ccagttcgtg tcttcaaaga agaaaatctg   422520
gctctccgtg cggccttgat tcgcattcgt agattgttag atacctatga gtctatggaa   422580
gacgaggaaa tgctggcgga gatgcgtaag ggtttggtgc gtcagatggg acttgtgggt   422640
caatttgaca tccattacca acgtaaggaa gaactcttct ttcctatcat ggagcgctat   422700
ggacacgatt cacctcccaa agttatgtgg ggagtggatg atcagattag ggaactcttt   422760
caaacagctc taacgacagc caagtcacta ccagaagtgt caattagcag tgtaaaggaa   422820
gcttttgaag cttttgcgac agagtttgaa agtatgattt tcaaggaaga gtccatcctc   422880
ctcatgattc tccttgagtc ttttactcag gatgactggc ttcagattgc ggaggagagc   422940
gatgcctatg gctatgccat catccgtccg tcagagaaat gggtgccaga acgacagagc   423000
tttattgagg aaaagattgc agaggagcct gtacagctag atacggcaga aggtcaagtt   423060
caacaagtca tagatacgcc agaaggccat tttaccatta cctttacccc taaggaaaag   423120
gaagctgtgc tggaccgcca tagtcaacag gcttttggta atggctatct ttcagtcgag   423180
caggccaatc tcatcctcaa tcatctccct atggagatta cctttgtcaa taaagaagat   423240
attttccagt attacaatga caatacgcca gctgatgaga tgattttcaa acggacgccg   423300
tcccaagtcg ggcgcaatgt cgaactctgc catccgccta agtacttgga caaggtcaaa   423360
actatcatga aggggcttcg tgagggaagc aaagacaagt atgaaatgtg gttcaagtct   423420
gagtcgcgag gtaagtttgt ccacatcacc tatgctgcag tacacgatga agacggagaa   423480
ttccaaggag tgttggagta tgttcaggat atccagccct accgtgagat tgatacggac   423540
tattttcgtg gattagaata aggagaaaaa atgagttacg aacaagaatt tatgaaggaa   423600
tttgaagctt gggtcaatac ccaaatcatg attaacgaca tggcgcacaa ggaaagccaa   423660
aaagtttacg aagaagacca ggacgagcgt gccaaagatg ccatgattcg ctacgagagt   423720
cgcttggatg cttatcagtt cttgcttggt aagtttgaaa acttcaaagt aggcaaggga   423780
ttccatgatt tgccagaagg cttgtttggt gagcgaaatt attaaacgag aaagattctt   423840
gatttttcac taaaatcttg atagaatgtt tatgttaaat ccttgtcaga gcagggattt   423900
tttattgaaa ggattttatc atgtcaaaga aactcaatcg taaaaaacaa ttacgaaatg   423960
gcctccgtcg cgcaggtgcc ttttcaagta cggtgactaa ggttgtagat gagacaaaaa   424020
aagtcgtgaa gcgtgcagaa cagtcagcaa gcgcagctgg taaggctgtt tctaaaaaag   424080
ttgaacaagc agtagaagct accaaagagc aagctcaaaa agtagctaat tctgtagaag   424140
attttgcagc aaatttgggt ggacttccac ttgatcgtgc caagactttc tatgatgaag   424200
gaatcaagtc tgcttcagat ttcaaaaact ggactgaaaa agaactcctt gccttgaaag   424260
gaatcggccc agctaccatc aagaaattga aagaaaatgg catcaagttc aagtaatttt   424320
tcttgagcct tgcatttccg aaaaaatctt gctacaatag agccattaga ggtgttttga   424380
atcccacatt ttacagaaag tggcggcgct gagaagtcca caaatgtgtc aaaactggtt   424440
gctaatggat gaaaaattga aataaaagtg tctttttgct ttaaagacga gagttgcggg   424500
caactgcccg aaattgggtg gtaccgcgga taaacacatt cgtccctgtc atgtagatgg   424560
cagggctttt cttttacgtc ttagtcaaag ggggttgtta tgaagcaatc ttttaacaca   424620
agtaaactat attatggttt tcctgttttt attttaggat atcaagatta gaattttggc   424680
tataacatca cgacctgtag ttcctcttat agtctaggag attgggttgt gattggagtc   424740
gttgcgagag agaatgccgc agagcagatc aaacagtatc aaaaatttac tgtgaatatt   424800
tctgatgaaa cttctatgct tgcgatggag caggctggtt ttatcagtca tcaggagaaa   424860
ttggaacgtt tgggagtgca ttatgaaatt tctgaacgaa ctcagactcc tattttagac   424920
gcctgtccac ttgttttaga ttgtcgggta gataggattg ttgaggaaga cggtatttgc   424980
cacatctttg ccaagattct tgagcgactt gttgccccag aactcctgga tgaaaaggga   425040
cattttaaaa atcaactgtt tgccccaacc tatttcatgg gagatggata tcagcgcgtt   425100
tatcgctatc tggacaagcg tgtagatatg aagggcagtt tcatcaaaaa agcgaggaag   425160
aaggatggca agaactgagc tgccagataa aatcgaaaca gaacgtctcg ttttacgagt   425220
ccgcacagtg gtggatgctg aggatatcca tacctacgct agtttgccag aggtcgccta   425280
tccagcaggt tttcctccag tcaagatctt ggaagatgag atttattatc tggagcacat   425340
tcttccggag cgtactcaaa aggaaaatct cccagctggc tatgggattg tcgtcaaagg   425400
aaccgataaa gtcattggtt ctgttgactt caaccatctt catgcggatg atgtgctaga   425460
gcttggctat accttgcacc cagactattg gggtcgaggt tatgttccag aagcagcgtg   425520
ttccttgatt gatctagctt ttaaagaact tggtcttcac aagattgaac taacttgctt   425580
tggatataac cttcaaagtc aacgagtctc ggaaaagctt ggctttaccc tcgaagctcg   425640
cataagagac cgcaaagatg ctcaaggcaa ctgctgtgat gatttgagat atggcttgct   425700
gaggagtgag tgggaggtga tttgatgcat cttttcatca ttggtgctcc agcatcagga   425760
aaaatgacca ttggtcaaga attatctcga ctgacggatg ctaccctatt ttataaccat   425820
caagccattg attttgcact agagatctat caggattata ccgaggagat gtgggaattt   425880
gttcgtggaa ttaccttttc tttccttgga gcaagtgcaa gaaatcagcg atcagtaatt   425940
ttaacagacg taattgattt ttcaaatcag taccagctga tgtatttaaa gcaaattcag   426000
gatttattgg ataactttca tcaagagatt ctgtttgttg aattggaaac aagtcttgaa   426060
gagtgcatac gtcgaaatcg aacggagaat cgattaaagc acaaaccctt aaaacgacat   426120
attgaggtat ctgaaagaga aattttagag accgctgaaa cacttcaatt aaattcccaa   426180
catcaaccga atgagttgca ccactacttt aaaataaata atacgaattt gtctgcagaa   426240
gaagctgcta agcaaattca aaataaaata aacaaaatag agaaaggaca cacacatgtc   426300
taaagaactt tcacctaaat acaatccagc cgaggttgag gctggtcgtt accaaaaatg   426360
gcttgatgcg gatgttttca agccttcagg cgatcaaaag gctaagcctt attcaatcgt   426420
gattccacca ccaaacgtaa ctgggaaact tcaccttggt cacgcttggg atacgacttt   426480
gcaggatatc atcatccgtc aaaaacgcat gcaaggcttt gatacccttt ggcttccagg   426540
tatggaccac gctggtattg cgactcaggc taaggttgag gagcgcttac gtggtgaggg   426600
tattacgcgt tatgacctag gtcgtgagtc tttcttgacg aaggtctggg aatggaaaga   426660
cgaatatgcc actaccatca aggaacaatg gggcaagatg gggctttctg tagactattc   426720
tcgtgagcgt ttcactcttg atgaaggttt gtcaaaagct gttcgtaagg tctttgtgaa   426780
cctttacaag aaaggctgga tctatcgtgg tgagtttatc atcaactggg acccagcagc   426840
tcgcacagcc ctttctgata ttgaggtgat tcacaaggat gtagaaggtg ccttctacca   426900
catgaattac atgctggaag atggttcacg cgcccttgaa gttgctacaa ctcgtcctga   426960
gactatgttt ggggacgttg cggttgcggt taatccagaa gacccgcgct acaaggactt   427020
gattggtaaa aacgtcatcc ttccaatcgc taataaactc atcccaatcg ttggagatga   427080
gcacgcagat cctgagcttg gtactggtgt cgtgaaaatc acacctgccc acgatccaaa   427140
tgacttcttg gttggccaac gtcataactt gccacaagtc aacgtcatga acgacgacgg   427200
aactatgaat gagcttgcct ttgaattttc aggcatggat cgttttgaag ctcgtaaggc   427260
agtcgttgct aagttggaag aaatcggtgc ccttgtcaaa atcgaaaaac gtgtccacag   427320
tgttggtcac tcagaacgta caggtgtcgt agttgagcca cgcttgtcta ctcaatggtt   427380
cgtcaagatg gaccaattgg ctaagaacgc cattgctaac caagacacag aggacaaggt   427440
cgaattctac ccacctcgtt tcaacgatac cttccttcaa tggatggaaa atgtccacga   427500
ctgggttatc tctcgtcagc tttggtgggg tcaccaaatc cctgcctggt acaatgctga   427560
tggtgaaatg tatgtcggcg aagaagctcc agaaggtgac ggatggactc aggacgaaga   427620
cgtcttggat acttggttca gttctgccct ctggccattt tcaaccatgg gctggcctga   427680
agtcgactca gaagacttta aacgttattt cccaacttca accttggtaa caggttacga   427740
catcatcttc ttctgggtgt ctcgtatgat cttccagtcc ttggaattta ctggtcgtca   427800
gccattccaa aacgtgctta tccacggtct catccgtgac gagcaaggac gcaagatgtc   427860
taaatctctc ggtaacggga ttgacccaat ggatgtcatc gagaaatacg gtgctgatgc   427920
ccttcgttgg ttcctttcaa acggttccgc accaggtcaa gacgttcgtt tctcttacga   427980
gaaaatggat gcttcatgga actttattaa caaaatttgg aacatttctc gctatatcct   428040
catgaacaat gaaggtttga cgctggatgt ggcgcatgac aatgtcacaa aagttgcaac   428100
aggtgaggct ggtaatgtga cggaccgctg gattctccac aatctcaacg aaaccattgc   428160
aaaagttact gaaaactttg ataagttcga gtttggtgtg gctggtcata tcctttacaa   428220
cttcatctgg gaagaatttg ccaactggta tgttgagttg accaaggaag ttctatacag   428280
cgacaatgaa gacgataagg tcattactcg atctgttctc ctctatacgc tggacaagat   428340
ccttcgtctc cttcacccaa tcatgccatt cgtgacagag gaaatctttg gacaaatctc   428400
agaaggttct atcgtgacag ctgcataccc aactgttaat ctagcctttg aagaccttgc   428460
ggctcacact ggtgtggaaa gtctcaaaga cttgattcgt gctgttcgga atgcgcgtgc   428520
ggaagtaaat gtagcaccaa gcaagcctat caccatcctt gttaagacaa gcgatagcga   428580
cttggaagcc ttctttaaca gcaatgtcaa ctatatcaaa cgctttacaa atccagaaca   428640
cttggaaatc gcatcaacca tccctgcacc tgaactggct atgtcaagtg tcatcacagg   428700
agcagaaatc tacctgccac tggccgatct cctcaatgtt gaagaagaac tggcccgtct   428760
cgacaaggaa cttgctaaat ggcaaaaaga actggacatg gttggtaaga aactctctaa   428820
cgaacgcttc gtagccaacg ccaaaccaga agtcgtccaa aaagaatgcg acaaacaagc   428880
tgactaccaa gctaaatatg acgcgaccgt cgcacgtatt gatgagatga agaagttggt   428940
gaaatgatgt taaaaaccta accctatcgg gttgggtttt acatttgata atgttataat   429000
aaaaaggaga aactttagga gaatactatg gggaaaattg ttgctattga tttatttaac   429060
ggtgcaggtg gcactacaag tggccttaaa aaatcaggca tagatgttca agttgctgtt   429120
gaaattgatt ccgtagctgt taaaacttat aagttaaata atcctgaggt gtctgtaata   429180
gatatggagt aaataaaact tcaattttac aagctttata tggttctcca gccaataaaa   429240
gtgtgtctga atattggttt agtacaaatg ttgatcaaat agatgaagtg gatgggaaac   429300
aatgtttaat ctattcatat tataacatta aagcttctag aaatgtagaa gttcttaaag   429360
gccgttctgg aacaaaaaaa ggattagatt attgggaacc atatgctcct caaaaacaat   429420
atgagatgga aagattaccc aaaaataaat atattggaag ttcttcgaca gacagatggg   429480
atggcattga aaaaaatgtt gtcttttgtg attgtaaaga atatgtttct gcttttgatt   429540
tatttttcta tcactataat tttaaaaaaa tttctactca acgtagtaaa caagatttta   429600
taagattacg atctaagcca gttgctgata ttttaaagaa taatacaagt agctatacgc   429660
gttataaaaa ggaaatggtt atagataatg ttaaagttga tgataaagtt tgtgaaatta   429720
ttagtgaaat aatggatgaa tcttatacag acattcaaat tttaacacat aagttgtatt   429780
caaaaggtga tgatataaaa gcttccaaaa ctatttggat gaaaaaatct ggaaaagaat   429840
attccgaggc ttttgcagga acaggtgagg ctagaattat tttgttagta aatgatatag   429900
taaatgcgca atcaaattca ttaatattaa tagatgaacc tgaaatctca cttcatccga   429960
gtgcaatcta taaatttaaa gagtttttac ttcaagagtg tttaaataaa aaacatcaaa   430020
ttattatcac tacacattct acacaactta taaaagattt tcctagagaa gccgtgaaac   430080
ttttagtgaa aaacggagaa aaggtagatg ttattgaaaa tattgattat caggatgcat   430140
tttttgaatt aggtgatgtg tatcattcta ggaagatgat ttatgttgaa gatagactag   430200
ctaaatatat tctagagttt gttatcactc attcaggtag tgagaatctt aaacagaatt   430260
tagtagtgag atatattcct ggtggagcaa atcaaataat ttgtaataat attttaaact   430320
catcgtattt agattccgat aaccattatt tttggcttga tggagatcaa aacactaatg   430380
ttagtgaatc aaataattta atgaactatc ttgaaaatgg tgttgttata tcagataaaa   430440
ttcctgaatc agataataaa aatcttgatg atattataaa attgataacg ggatgtccaa   430500
ttaaatttaa tgtttcaggt aataaagggc aaaaaaataa tattgaatta attgcgaaac   430560
aaagaagctt tatagattat tgggctaaat acgtttctta tcttcctttc ccaaccccag   430620
agtttttttt agctaatttg tgtaacagcg tagataggga aggttatgat ttttctaaag   430680
atggcaacgg aaaagaatat tttagaaaaa aaactcaagt agcgttagga atagagaata   430740
taacttctga agatattttc caggagcaaa gaagagctgt ttcaaaaata cagccagaat   430800
catcaatgtt tcagtgtatt aaagaaaaat tagaggcatt gttctaattc cttagattag   430860
gtactacata acaaattttt taaattcaaa cccgcaccaa aaacaacatt gcaactttct   430920
tctcaggtaa tgtgttggga tttgaacaga ccaacgagtt catagtggtg tatgccaatg   430980
actttgataa gtctacgcgt cagacttatt agttcattta tccagatata tctcgataat   431040
catattattt agtcaaagaa catcccatat gagggcatga aatgctaagt ttagcttgct   431100
cactattaag atgaagtata tatatttcat agaacctatt gtgaaggatt tttataattt   431160
tcgccaattc catacctatt tcacaattta ccgatgacac agaaaaacaa ttgaaaggat   431220
atttctatgc aaccaactta caacattgac aatccaaact tgtcttatga agcgaagcgt   431280
gatttatggc ggataggttt tggtctgcag aaagttgaca atctagtgcc atcagcgtat   431340
atggaatctt tggctgagaa acagtcccgg ggtgaactga cttatgagca ggtttatgag   431400
gatgcaacgg cttatcatca taccattgat gcgagtacag aggaggcaga cttggtttct   431460
ctacgtattg tagaactatt gtctcgaaga ggctttagct tcagtcctgc gatcttactt   431520
gctattcata aggagttgtt tcaagatata tttgaaccct cgattccggt aggtcaattt   431580
cgtcagacta atatcacaaa gaatgaacct gttttgaatg gtgaaagtgt tgtgtactct   431640
gattactcca tgattcaaat gaccttggat tatgatttta atcaggaaaa acaagttgca   431700
tatgcgacac taacccaggc ggatatggtt aaaaaaatcc agcattttat ttcaggaatc   431760
tggcagattc atccatttcg cgaaggaaac actcggacgg taacggtatt tttgattcag   431820
tatcttcgtg agtttggttt tgatattgat aatacaccat ttcagcaaca ttccaagtat   431880
tttcgtgatg ccttagtgtt agataatgca aagattttac agcgacgtcc tgagttttta   431940
acagcttttt ttgaaaatct cttgctcggt ggtcaaaatg atttgtcttc agaaaaaatg   432000
tatctagatt tagacctcga tctttcataa tcctaatact gagtaaacat tgaattttag   432060
gaaaaaatga agtaaatatt ctcacaagaa aacgtatatc atcaaagttt ggctctttgt   432120
caattgtagt gggttgaaga aaagctaagt tcgagaaagg acaaatttcg tcctttcttt   432180
tttgatgttc agagcgataa aaatccgttt ttttgaagtt ttcaaagttt cgaaaaccaa   432240
aggcattgcg cttgataagt ttgatgagat tattggtcgc ttccagtttg gcattagaat   432300
agtgtagttg aagggcgttg ataacctttt ctttatcttt gaggaaggtt ttaaagacag   432360
tctgaaaaat aggatgaacc tgcttaagat tgtcctcgat aagttcgaaa aatttctccg   432420
gttccttatt ctgaaagtga aacagcaaga gttgatagag ctgatagtga tgtttcaagt   432480
cttgtgaata gctcaaaagc ttgtctaaaa tctctttatt ggttaaatgc atacgaaaag   432540
tagggcgata aaaatgttta tcgctgagtt tacggctatc ctgttgaatg agtttccagt   432600
agcgcttgat agccttgtat tcatgggatt ttcgatgaaa ctgattcatg atttggacac   432660
gcacacgact catagcacgg ctaagatgtt gtacaatatg aaagcgatca agaacgattt   432720
tagcattcgg gagtgaaaca gtctgggaga ctgtttcagc ctgagcctag aaatttgaaa   432780
gcgaagctgt ttagctaagt catagtaagg actaaacata tccatagtaa taattttgac   432840
gcgacatcgg acggctctat catatttaag aaagtgatct cggatgacag cttgtgttct   432900
accctcaaga acagtgatga tatcgagctt ttcaaaatct tgcgcaataa agctcatctc   432960
catctcccga ttgaaacagt cactccccgg actgtttcaa cgtcccaaga cataatctta   433020
ggcagatttc taaaattaca ctcaaagtgg aagtcattga gctttcgaat gacagttgaa   433080
gttgaaatgg ccagctgatg ggcaatatcg gtcatagaaa tcttttcaat taacttttgc   433140
gcaatctttt ggttgataat acgaggaatt tggtgatttt tcttgacgat agaagtttca   433200
gcgaccatca ttttcaagca atgatagcac ttaaaacgac gttttctaag gagaattcta   433260
gtaggcatac cagtcgtttc aaggtaagga attttatagg gtctttaatg tctagtaatt   433320
ttgtgataaa atgtaattgt tccatatgat tctttctaat gagttgtttt gtcgcttttc   433380
attatagatc ttatgggact ttttttctac ccaaaatagg ctccataata tccataggga   433440
atttacccac tacaaatatt atagagccca aagttttagg tcgcttgata atatgcgttt   433500
tttgaatttt atagactgct cgtttaaact ctatttactt cgtaccttct ggagcgagac   433560
ggaatattag tcacatacaa aatgagtact attaggattt tattttcatg tacaatttca   433620
gccagtcttg ttataatcag cctataggaa tcaaggaggt gactcttatg gctgtttttg   433680
tgtctttgga tggaattgtg gtagaagtcc ttgatgtctt ttcttctttt aatggggata   433740
gtgagttttt cttgtgtata gcattttgaa tctggaatag gacgccatga ctgctaaaag   433800
atttctataa attaatttga ttttcctaat caatttgttc atatcttatt tcattccact   433860
ataaacgtct taaagacaag agtcagtttg ttatggaacg ctctcagttc gaggagatgt   433920
tccaacttca aagtagtcgc ttgacgacgc aagaaaaatt acaattgttt acctctgtgt   433980
ttgctggccg ttatgatgtt tatgctaaga attttatcaa tgaacaaggg aaaattcagt   434040
attttccttc ctatgattat ggttggaagc agttgccacc tgaaaaacgg agtttccaga   434100
cattgacgaa ctccgttttg aaatctcatt ttcgtgggga ggcagctatc ggtatctttc   434160
ctatgcactt agatgatagc tgttattttt tggtactgga tttggatgaa ggagattgga   434220
aagaagctgg tttaaccatt cgaagaatag ccagggaacg ccagatggaa gcccatttag   434280
agatttctcg ttcgggtcac ggactccata tttggttctt ctttgaggaa gcgattccga   434340
gtcgagaggc tcgcttgttt ggaaagaaac tgatagaact ggcaatgcag gaaagtatgc   434400
aactgtcctt tgattctttt gatcgcatgt ttccaaatca ggatgtcctt cctaaggggg   434460
gatttggaaa tttgattgcc ttgccttttc aaggagaagc ttaccatcaa gggcgaacgg   434520
tctttgtgga tgaacagttt cagccttatg aagaccaatg gaggtatcta caagaaattc   434580
agaggatttc aactgctaaa gtggcactgt taatccaaga ggagttaggc aagcaagaat   434640
tggataagga gttgaaggtc gttttatcca atatgatcca acttgaaaaa tcgtctgtga   434700
catccaaggc acttttttct tgaaaaatat ggcttccttt tctaatcccg aattttatag   434760
tagattgaaa ctagaatagt acacctctgc ttctaaaaca ttgttagaaa tcgatttgac   434820
tttcctgatc gatttgtcct gttattattt cattttacta tatttaaagc aggctatgcg   434880
acagccaacc tatcaaattc ctgagagaat gtatttattt ggagaatccg atcattattt   434940
atggttgcca agaggtttgc tgtatccatt gcaagataaa tttaagcagg tatctgtgga   435000
agataggaga aaggtacaaa ggtctattag cgtggaattt aagggagaac tcacttttga   435060
gcaagagtta gccctgtcag atatgacttc taaagaaaat ggtttacttc atgcggagac   435120
tggttttggg aagaccgttt taggtgctgc tcttatctct gaacggaaaa caaaaacaat   435180
tattctagtc cataataagc aactcttaga ccaatggcta gatcgcttaa actgcttttt   435240
gactttcgaa gaggaggagg ctatccgtta tacggcatca ggtcgtgaaa aggtaatcgg   435300
ctatgttggg cagtacggtg ggactaagaa atggctgagt aaactggttg atgtcgttat   435360
gattcaatct ctatttaagt tggaaaatag tcaaagtctt ttggatgagt atgagatgat   435420
gattgtggat gagtgtcatc atgtctctgc cttgatgttt gaaaaagttg ttgctcagtt   435480
tagagggaag tatctttacg gtttgacggc tacgcctgag cgtaagaatg gtcatgagcc   435540
tattgttttt cagagaattg gtgagatact ccatactgct gataagaggg aaacggattt   435600
taaacggcaa ttgcaattaa gattcacttc ttttggtcat ttggaaattg aaaagaccaa   435660
agcaagtaat tttatacagc ttagtgattg gattgctact gactcagtga ggaatcagat   435720
gattctcaag gatattctag cccaagtggc agaaggacgg aatatcttgg ttttagttaa   435780
tcgaattcaa cagatagatg tctttgaaaa attattgaaa gagaaagagg ttgatgactg   435840
ttacattatt agcggaaaaa ccaaagtccg agagagaacg agtttactgg agacgttaga   435900
acagttagat aaagggtttg ttttgttgtc tactggaaaa tacattggcg aaggttttga   435960
cttacctcag ttggacacgc ttatcttggc agcacccttt tcttggaaaa ataatttgat   436020
tcagtatgca ggtcggattc atagaaacta caaggataag tctttggtgc gtattttcga   436080
ttatgtggat attcatgttc cttatttaga aaagatgttt cagaaacgac aagtagctta   436140
tcgaaagatg gattatcgtg tcatcgaggg tgaggagaaa caattcgttt atgttgatag   436200
tagatatgag aaggtgttga gagaggactt agcaggggaa agacaggaat gtctgcttat   436260
tttaccttat gtgcaccaga caaaactgat gaattttcta aaagaattta ggattagtca   436320
aattgagata tgtataccag agacggttgc aaataaagca tggctagacc agttgaagag   436380
ccagaaaatt aaagtgtctt ttactcaatc aaaaatagta acgcctattc ttttggtgaa   436440
taagactatt gtttggtatg gtgcaatgcc attattaggg aaggtagatg agatgaccat   436500
attacgtttg gaatcagcta gtatagtttc tgaactagtg gcaggtttac gatagagaaa   436560
atttttaaaa atttctatgt atgattttca tttctttagt gagactgttg ccattatcac   436620
attcgaatca cacaaaataa aaaaattttt ataagtactt gacaaataga ttgaaatatc   436680
ataaaataaa aacggttaca gagttattaa ttatttaagc ttcatgtcac cattaaaaat   436740
tgaaataaaa ggatgttatc actaatacaa gtgagcagga acctatttaa tcacatcaga   436800
agaagtttct tgatgttttt aagtaggttc cttttatttt aaaagggaaa ttttatgatc   436860
ataaaacgaa tactaaacca caatgccgta attgcgcaaa gtaaaaaaga tatcgatatt   436920
cttctttttg gaaggggaat agcttttgga agaaaaactg gagataaagt aaatccaatt   436980
gatattgaga aaagtttttt tctcaaaaat agagataata tgacccgttt tacagagatg   437040
tttattaacg ttcctttgga gttggtgtac atcaccgaaa aaataattaa cctaggtaaa   437100
ataacattgg gtaataattt tgatgaaatt atctatatta atttaacgga tcatatttct   437160
tcgagcatag aacgttataa agaagggatt attatttcga atcccctacg ctgggaaata   437220
tcgaaatatt ataaagaaga atttgaactt gggaaaaggg ctttacaaat aataaaaaaa   437280
gagttaggta ttgaacttcc aattgacgaa gctgcattca tagcgctaca ttttgttaat   437340
gctaatttag aaaataattt tcaagagtcg tataaaatca ctgaaataat tatgggaatt   437400
gagaaaatca ttcaagattt ctattgtact gagtttaacc aagattctat tgattattat   437460
agattcataa ctcatataaa attatttgcc catcgcttgg ttgaaaatac aacttattgt   437520
gacgatgatg atgaagactt gttagcatta atgaaaaata aatatcctag agaatatgaa   437580
tgtggtgaac aggtagcaat gtttatacaa acggagtaca attatttgct gacttctagt   437640
gaattagttt atttgatggc tcatattcgt cgcttaacaa aaaatttaga ttaatagaat   437700
aggagaatac catgagttat aaagatacgg tacaaaaaat cctcgatgta attggaggtg   437760
aaaaaaatgt caatagagtt acccattgtg taacacgttt aagattagaa ttaaaagatg   437820
aaaatttagt caatgatgat gatgtgaaga agataccagg tgtaataggt attatgaaaa   437880
agaatggaca atatcaaatt atacttggta atgatgtagc taattattat aaagaattcg   437940
ttaaacttgg caattttgaa tccgattcag ttgttcaagg gcacaaaggg aatattttag   438000
aaagaatcat tgagtatatc gctggttcca tgactccaat cattccagca atgttagggg   438060
gaggtatgtt gaaagtcttg gtaatcattt taccaatgct tggtatattg caatcagatt   438120
ctcagactat tgcttttttg acattttttg gggatgctcc atattatttc ttaccgctgt   438180
tattagctta ttctgcatca caaaaattaa aagtaacatc tacattagct atgtctgtag   438240
caggtgtact tctccatcca aattttgttc aaatggtgca atcagggaat cctcttagtt   438300
tatttggtgc acctgtgaca ccagctagtt atggttcatc agtcgttcca attcttatta   438360
tggtttggtt gatgaaatat attgaaaaaa taattgctaa attaacacta gctattacta   438420
agagtttttt gcaacctacg ctagtattat tagtatcaag ctgtattgcc ttagttgtag   438480
tcggacctat tggagtaatt gttggtgaag gattatcaaa tctagttggg caaatgtatg   438540
gtgtagctgg atggcttaca ttagctattc ttggtgctat tatgccattt attgttatga   438600
ctggaatgca ttgggctttt gcacctattt ttttggcggc atctattgct actccagacg   438660
tattaattct tccagcaatg ttagggtcaa acttagctca aggggctgct tcgatggctg   438720
ttgcattaaa gagtaaaaat aataatacaa aacaaattgc ttttgcagca ggtttctcag   438780
ccttacttgc agggattacc gaacctgcat tatatggtgt gactttaaaa tataaaaaac   438840
cgctttatgc agctatgatt ggtggtggat tagcgggatt atttgcaggt cttactagtg   438900
ttaaagcata tctatttgct gtcccatctt tgatagcgtt gcctcaattt atttattctg   438960
atgtgccatc aaatattgta aatgctttaa ttgtggcggt catttcggtt gttattacct   439020
ttgtattagc ttatatattt ggaatcgatg aagaagagag ttctagcaat ttagaagttg   439080
aagctggagt ttcaaataaa aaaatgatat tttctcctat atcaggagaa atcattccgt   439140
taagcgatgt ccaggataaa acattttcag ataaactaat tggagacgga gtagcgatta   439200
tcccaagtga aggtaaggtt tatgcaccat ttgatgggaa aattacaaat atttttccga   439260
ctaagcacgc aattggattg aagagtgatg agggtgttga gttactaatt catattggat   439320
tagatactgt tgagctaaaa ggtcaaggtt ttattagtca tgtagaagaa ggagacagag   439380
ttttcaaaaa tcagttgatt tttgaaatgg acttgaattt aatcaagact aaaggctacg   439440
aaacagttac accagtaatt gtaacgaata ccaatgattt tctagatgta ttagtattac   439500
ctaataatca gacaatcgag cattctaagg aattactggt aatattataa tggaggaaag   439560
ttatgaccat ttttccagat gattttcttt ggggtggagc tgttgcagct aatcaagtag   439620
agggagcata taatgaagat ggtaagggct tatcagttca ggatgtgtta cccaaaggtg   439680
gattaggaga agcaacagaa aatcctacag aagataactt aaaattgata ggtattgatt   439740
tttatcataa atataaggaa gatatatcct tgttttctga aatgggcttt aatgtttttc   439800
gtacttctat tgcatggagt agaatttttc caaaaggaga tgaggaagaa cctaacgaag   439860
ctgggttgaa atattatgat gaattgtttg atgaactaca tgctcacggg atagaaccac   439920
ttgtaactct ttcacactat gagactccat tatatttagc aagaaaatat catggatggg   439980
ttgataggag aatgattcat ttttatgaaa aatttgctcg aacagtttta gaaaggtata   440040
aagataaagt taaatattgg cttacattta acgaagtaaa ctctgttttg gaattaccat   440100
ttactagtgg aggaatagat atacctaagg agaatctttc gaaacaagaa ttatatcaag   440160
ctatacatca tgaattagtc gcctcaagtt tggttacaaa aattgctcgt gagattaatt   440220
cagagtttaa ggtgggatgt atggtattag ctatgccagc ttatccaatg actccaaatc   440280
caaaagatgt atgggcgact catgagtatg agaatctaaa ttatctattt tcagatgtgc   440340
atgttagagg ttattatccg aattatgcaa aaagatattt taaggaaaat gacattaaca   440400
tagagtttgc agctgaagat gcagagttat taaaaaatta taccgtagat tttttatcct   440460
ttagctatta catgagtgtg actcaatctg ctcttccaac acagtataat tcaggagaag   440520
ggaatattat tggtggttta gtaaatcctt atttagagtc ttcagagtgg ggatggcaaa   440580
ttgatccaat tggactacgt ataattttaa atagatatta tgaccgttat caaatcccat   440640
tatttatagt agaaaatgga ttaggtgcta aagatcaact aataaaagat gaacttaata   440700
acttaaccgt ccaagatgat tatagaattc agtatatgaa agaacattta ttgcaagttg   440760
ctgaagctct acaggatggt gttgaaatta tgggctatac gtcttgggga tgtattgact   440820
gtgtttctat gtccactgca caactttcta aaaggtacgg tctcatttat gttgatcgaa   440880
acgatgatgg aagtggtaca ttaaatcgat ataagaaaat gtcttttact tggtataaag   440940
aagtgattga atcaaatgga gaatccttat tcaaatagtt ttttattgat gactagctat   441000
tatcacggtt aaggtggcat ttcattaaat atggaataaa gaagtttgga agacattaaa   441060
ttctaaactt ctttatttta taggggagtg tcaattaatt taattttgtt acaaaaatta   441120
taaatagtta atttagataa attgtttata taaatttaga taagaataag ctaacaagca   441180
gaagtaagat aggtcttgca agaatggtaa aaatctgata aactaagtag taattgaata   441240
ggaatctgaa agactagtag cccaagggaa gtatatcagg gaggagagcc gtgactgcaa   441300
gctctctata tgaaagctgg gtgaattcac ttgcgcatgg atttagaaat gaaggtctga   441360
cttgtcagat gaaaacggat ggtaccgcgt gtcaacgctc cgagtggagt ttttggcatg   441420
tggttttctt tttatctacg agagactgat ggaggaaata tgtcaactat tgaagaacaa   441480
ttaaaagcgc ttcgcgaaga aacgctggct agcttgaagc agattactgc tggaaatgaa   441540
aaagagatgc aagatttgcg tgtctctgtc cttggtaaaa agggttcgct cactgaaatc   441600
ctcaaaggga tgaaagatgt ttctgctgag atgcgtccaa tcatcgggaa acacgtcaat   441660
gaagctcgtg atgtcttgac tgctgctttt gaagaaacag ctaagctctt ggaagaaaag   441720
aaagtcgcgg ctcaactggc tagcgagagt atagatgtga cgcttccagg tcgtccagtt   441780
gcgactggtc accgtcacgt tttgacacaa accagtgaag aaatcgaaga tatcttcatc   441840
ggtatgggtt atcaagtcgt ggatggtttt gaagtggagc aagactacta taactttgaa   441900
cgtatgaacc ttccaaaaga ccacccagct cgtgatatgc aggatacttt ctatatcact   441960
gaagaaatct tgctccgtac ccacacgtct ccagttcagg cgcgtgctat ggatgcccat   442020
gatttttcta aaggtccttt gaagatgatc tcgccagggc gtgtcttccg tcgcgatacg   442080
gacgatgcga cccacagtca ccaattccac caaatcgaag gcttggtagt tgggaaaaat   442140
atctctatgg ctgatcttca aggaacgctt cagttgattg tccaaaaaat gtttggtgaa   442200
gagcgtcaaa ttcgtttgcg tccatcttac ttcccattca cagagccatc tgttgaggtg   442260
gatgtttctt gcttcaagtg tggtggagaa ggctgtaatg tatgtaagaa aacaggttgg   442320
atcgaaatta tgggggccgg tatggttcac ccacgtgtcc ttgaaatgag tggtatcgat   442380
gcgactgtat actctggctt tgcctttggt cttggacaag agcgtgtagc tatgctccgt   442440
tatggaatca acgatatccg tggattctac caaggagatg tccgcttctc agaacagttt   442500
aaataatgat tagaaaagta gaaatggcag atgttgaggt gttggctaaa attgccaaac   442560
aaacctttcg tgaaaccttt gcgtatgata atacggaaga gcagttacag gaatactttg   442620
aagaggctta tagtctgaaa actttgtcaa ctgagttggg aaatcctgac tctgaaacct   442680
atttcattat gcatgaggag gagatagctg gttttctcaa agtcaactgg ggaagtgctc   442740
aaactgagag agaattagag gacgcttttg aaattcaacg tctctatgtg ctacaaaaat   442800
tccaaggatt tggactaggt aagcaactgt ttgaattcgc acttgaactt gctacaaaaa   442860
atagtttttc ttgggcttgg ctaggtgttt gggagcataa tacaaaagct caagcgtttt   442920
ataaccgata tggttttgaa aaatttagcc aacatcattt tatggttggt caaaaagtag   442980
atacggattg gttactgaga aagaaattaa ggtaagaaga ggattcttct attgaaatga   443040
taggaaagga aaagaactag agtgacaact gtcattctgg agaactaaat tatgcttgta   443100
tcttataaat ggttaaaaga attggtggac attgatgtgc catcacaaga gttggctgaa   443160
aaaatgtcaa ctacagggat cgaggtagag ggtgtcgaat caccagctgc tggtctctca   443220
aaaattgtcg tcggtgaggt cttgtcttgc gaagatgtgc cagagactca cctccatgtt   443280
tgtcagatta acgttggcga agaagaagag cgtcagatcg tttgtggtgc cccaaatgtg   443340
cgtgctggga tcaaggtcat ggtggctctt ccaggagctc gtatcgctga taactacaaa   443400
atcaaaaaag gaaaaatccg tggtttggag tcacttggaa tgatctgttc acttggtgaa   443460
ttgggaattt ctgactcagt tgtgcctaag gaattcgcag atggcatcca aatcttgcct   443520
gaagatgccg tgccaggtga ggaagtcttt tcttacctag acttggatga tgaaatcatc   443580
gaactttcca tcacaccaaa ccgtgcagat gccctttcta tgtgtggagt ggctcacgaa   443640
gtggcagcca tctatgacaa ggcagtcaac tttaaaaaat ttactctaac agaaactaat   443700
gaagctgcgg cagatgccct ttctgtcagc attgagacag acaaggcgcc ttactatgca   443760
gctcgtatct tggacaatgt gactatcgca ccaagtccac aatggttgca aaaccttctc   443820
atgaacgaag gcatccgtcc catcaataac gttgtagacg tgacaaacta catcctgctc   443880
tactttggtc aacctatgca tgcttttgac ttggacacat ttgaagggac tgacatccgt   443940
gtgcgtgaag cgcgtgatgg tgaaaaatta gtgaccctgg acggtgaaga acgagacttg   444000
gctgagacag acctcgtgat tacagttgct gacaaaccag tagcccttgc cggtgttatg   444060
ggtggtcagg ctacagaaat ttctgaaaaa tctagtcgtg ttatccttga agctgctgtt   444120
tttaatggca aatctatccg taagacaagt ggtcgcctga accttcgttc tgagtcatct   444180
tctcgctttg aaaaaggaat taatgtggca acagttaatg aagcccttga tgcggcagct   444240
agcatgattg cagagcttgc aggcgcgacg gtgcgtaagg gtatcgtttc agcgggtgag   444300
cttgatacct ctgatgtgga agtttcttca acccttgctg atgttaaccg tgtcctcgga   444360
actgagctgt cttatgctga tgtagaagac gtcttccgtc gtcttggctt tggtctttct   444420
ggaaatgcag acagctttac agtcagcgta ccacgtcgtc gttgggatat cacaatcgaa   444480
gctgatctct ttgaagaaat cgctcgtatc tatggatatg accgcttgcc aaccagcctt   444540
ccaaaagacg atggtacagc tggtgaattg actgtgatac aaaaactccg ccgtcaagtt   444600
cgtaccattg ctgaaggagc aggtttgaca gaaatcatca cctatgctct gacaactcct   444660
gaaaaagcag ttgagttcac agctcaacca agtaacctta ctgaactcat gtggccaatg   444720
actgtggatc gttcagtcct ccgtcaaaat atgatttcag ggatccttga taccgttgcc   444780
tacaacgtgg ctcgtaagaa taaaaacttg gccctttatg agattggaaa agtctttgaa   444840
caaacaggta atccaaaaga agaacttcca aatgagatca acagctttgc ctttgccttg   444900
acaggcttgg ttgctgaaaa agatttccaa acagcagcag ttccagttga tttcttctat   444960
gctaagggaa tccttgaagc cctatttact cgtttgggac tccaagtaac ctatacagca   445020
acatctgaaa tcgttagcct tcatccaggt cgtacagccg tgatttcact cggtgaccaa   445080
gttcttggtt tccttggcca agtgcatcca gtcactgcca aggcttacga tattccagaa   445140
acgtatgtag ctgagcttaa cctttcagcc atcgaagggg cgctccaacc tgctgttcca   445200
tttgtggaaa tcaccaaatt cccagcagtc agccgtgacg ttgcccttct cctcaaggca   445260
gaagtgactc accaagaagt tgtagatgct atccaagctg ccggcgtgaa acgtttgaca   445320
gatatcaaac tctttgacgt cttctcaggt gaaaaactgg gacttggtat gaagtcaatg   445380
gcttatagct tgaccttcca aaatccagaa gacagcttaa cggacgaaga agtcgcacgc   445440
tatatggaaa aaatccaagc gtctctcgaa gaaaaagtca atgcagaagt gcgttaaacg   445500
atagtaggat acaaattccc cctctagttt atgaacatta gaggggtgat tttatataaa   445560
ataattaaaa tgtgatttct gtaaaaatac atctatgatc agagttttga aaacttacaa   445620
tgtctaaatc tttaacatag tagtggtttt taggcaataa aatatgatct attgttgcat   445680
taaaaagttt tggactttgg ctattccaag ttcctctttc aaaaggtggc agtgcattta   445740
atgcgtccct atgagagctt atttttgcaa gtgctccatg acgcatagtt gcattaaaat   445800
cacctgcaat aatagccttt ggatattttg aagccaattg attatgaatg atgtttaagt   445860
cttgcttcca gatttccatt aaacctggca gaggaggcgc agtatgcaag gcaatgatat   445920
ctggtatatt ttgttttctc gaatgtaata caattgtccc gaaccgtgtt gtatgaaaag   445980
ttttagcttc tgtatagaaa ccataacttt tcttgacaat cacagtcaca ggagctattc   446040
cactattggt aggtggagaa gtgaaaatat catagttggc catagaaagt ccaacttgat   446100
gaaacaatag tttgattctc tggttttctt gctcacctct gatattggta gctagttcag   446160
ggaatatagc catatcggcg tcaaaatggc taaaaattcg ctcaatatgt tgtgcttcta   446220
tttgattagc gacgttccaa gttactaatt ttaaggtttt agtcttattt gatgcagaag   446280
aaagggtttt atctgttccg aataatagta atatgagcga tagtaagagc aaaatgccag   446340
agtaaaaccg tatttgttta tttttcttgt aaaaagatag gaaaaaaaat aagaaactta   446400
aaatagcagc catagttgca gtagctaagg ggaaggcata aatctgtgcc aagataggtt   446460
gggtagatag ccaaatgtta agattagaag atgggaaaaa agaataagtt atgataggga   446520
tagaaaagag aatgaccgaa agggcagaga gaaatgtttt aatcattgtg tgagtacctc   446580
aatttgcaat ggttgctcgg agctaatgtg actttgtgac tttacttgat tgatattctt   446640
tttcttgtct tcctcataga ttaagtacaa cccaagtaaa aaaagtccaa tttaagattg   446700
aaatgattaa aaggcacaga aatgcaagac aattatacta caaaaggcaa acatttgaca   446760
atcgatagcc gtcgcttaat cgaacgatgg aaaaaagaag gaaaatcaaa tagagaaatt   446820
gcctctctac ttggaaaagc tcctcaaact atccacactg aaatcaagcg tgggacagtc   446880
cgacaatgtc ttggaaaagg gcgcttcaaa gagatttatt ctgccgacta cgctcaacag   446940
tcttaagaaa ctaaaggaaa agattctcca ctatacataa ccaaaaacat aaccaaaaat   447000
tttcgcctga aatgatggtg atggctaaag gggttaacgt gggaatttca accatttact   447060
attggattca tcgtggaaaa ttggggttaa gcaagcagga actgctttat cctagaaaag   447120
gaaaatcgct taagaaatag gctagcacca actttaaacc cactggtcaa tctatcgaat   447180
cataattcgc tcattttttt aaaaatacat agacgtaaaa aaaagagggt taagtgatga   447240
agaatagtgc tattgggagt aattggaagg atgtccatct gagctcttta gcaaggagga   447300
aatccttgaa agtgatatgc gagtggctat catgagcgag ttgattgagg ctaggtatga   447360
acaaggaatc agtcagaaaa agctggaaga agtcagtgga ataagccagc ctgtcatagc   447420
taggatggag acaggaaaga ctagtcctca gttggataca gtcttaaaag tcctagccag   447480
tttaggaaag acactagcaa tcgtcccact tgaacaggga aaaagttgac tagaatcagt   447540
tatagtcttt tctaataaca ggtcatagtc acttataaga attactaata acatgtttta   447600
gtattctaat tggaatatag ctgtaaagta agaattacaa aggatttgag acgtttgctt   447660
caagtctttt tcttttgtcc gaaacagata tatagtttca aactatatca aaccctaatt   447720
ttttacaatt atacagacgc tttcttttct gttaagatag tttcaacaac aaattttgga   447780
ggacacatca tgtcaactac aatcatcggt ttccctcgtt tgggcgaatt ccgtgaatta   447840
aaatttacaa ctgaaaaata ctttagaaaa gaaatctcag aagaagaact tttagcagca   447900
gcaaaagact tgcgtgctaa acactggaac attgtcaaag aaaaaggcat cactgaaatt   447960
ccatcaaatg acttttctca ctatgataac ttcctagatg cggctttcct tttcaacgtg   448020
gtgcctgcat ccgttcaaaa cttggacttg tctgaccttg agcgctactt cgctttggga   448080
cgtggttacc agggagaaaa aggggacgtt cgcgcccttc caatgaagaa atggttcaac   448140
actaactacc actacatcgt tcctaaattt gaaaaagaca ctcaagtaaa attggctggt   448200
cacaagattt tcgatgagtt ccaagaagcc aaagaacttg gattgaacac tcgtcctgtt   448260
cttgtaggtc ccttcacttt ccttcaattg tcagactttg aagaaggcgt gaaagcagac   448320
gacttcgtag atagcttagt ggctgcttac caagaagttt ttgctaaatt ggctgaactt   448380
ggtgcgactc gcatccaatt ggatgaagcg gctcttgtaa aagacttgac agctgaagaa   448440
aaagctctct tcttgaacct ttacaacaaa ctcttggctg acaaaaaagg tcttgaagtc   448500
ttgcttcaaa cttatttcgg tgatgttcgt gacgtatacg ctgaccttgt aaacttacca   448560
gtagatgcta tcggtcttga ctttgttgaa ggtaagaaaa ctcttgaact cgttaaaggt   448620
ggcttcccag ctgacaagac tctctatgta ggtattgtca atggtaaaaa catctggcgc   448680
aacaactacg aaaagagctt ggctgttctt gagcaaattc cagctgaaaa catcgttttg   448740
acaagctctt gctcacttct tcatgtgcca tttacaactg ctaatgaaga atttgaacca   448800
gcactcttga accactttgc ctttgcagtt gaaaaattgg atgaaatccg tgacttggat   448860
gctatccgaa atggtcaagg ttcagaagct cttgcagcca acaaagaact ctttgcgact   448920
gagcgtgttg gtgaaaatgc tgaacttcgt gcgcgtatcg ctggcttgac agacgcagac   448980
tacactcgtt tgccagcctt tgcagaacgt gaagctatcc aagaagaagc tttcaaactt   449040
ccagctcttc caacaacaac gattggttca ttccctcaaa caaaagaagt tcgtgccaaa   449100
cgtttggctt accgtaaagg tgaattgtct caaaaagagt acgacgcttt ccttgctgaa   449160
acgattgacg aatggatcaa gtggcaagaa gatattgact ttgatgtcct tgttcacggt   449220
gaatttgagc gtaatgacat ggttgagtac ttcggtcaaa acttgtcagg atacctcttc   449280
tctaaaaatg gatgggtaca atcatacggt atgcgtgggg taaaaccacc aatcatctgg   449340
ggtgatgtca ctcgtcttaa ccctatcact gttaaatggt ctagctatgc acaaagtcgt   449400
acaaacaaac ctgttaaagg tatgttgact ggacctgtta ccatccttaa ctggtcattc   449460
ccacgtgaag acatctctat caaggattca actctccaaa tcgcccttgc tatcaaggat   449520
gaagtacttg accttgaagc tgctggtgtg aaaatcatcc aaatcgacga ggctgctctt   449580
cgtgaaaaat tgccactccg ccgtagcgac tggtacgaag actaccttga ctgggctatt   449640
cctgccttcc gcttggtaca ctcaacagta gcgccagaca cacaaatcca cactcacatg   449700
tgttactcag aatttacaga tatcatccca gctatcgata acatggatgc agacgttatt   449760
tcctttgaag ctaaccgttc aaaccttgaa atcttggacg aactcaaagc gaaaaacttc   449820
caaacagaag tgggacctgg ggtttacgat atccactcac ctcgtgtacc aaatgaaggc   449880
gaaatcgaca acacaatcga agccatcctt gctaaagtgc caagcaagaa agtttggatc   449940
aaccctgact gtggtttgaa aacacgtggt atcccagaaa caaaagaaag cttgatccgc   450000
cttgttgaag cagctaaagc tgcgcgtgag aaattgtaag attggatttc tctccataca   450060
gtggttgttc aaaaagaaat caactagaaa aggttattac atatgtcacg ccaaacaccg   450120
tcactctcat ttgaagtgtt ccctccaaac ccagccgtgg gtaatgataa cattatttca   450180
gccttgcagg atatgcagga gttggctccc cattttatca gtgtaactgc cagcaataat   450240
aaatttaata tcaaggaaac gacggttcgt ttggctgact ttatccaaaa tgatttggcg   450300
attccgacca ttgcccactt gccagctatt tatctaacta aggacaaggt tgctgaaact   450360
attgctgact tggacaaagt tggggtgcag aaaatcttgg ctcttcgtgg ggatattatt   450420
ccagacgtgg aaccacaaaa ggatttccgc tatgcaaccg acttgattga gtttatcaag   450480
gaacaaaccc ctcactttga tattattgga gcttgctatc cagaagggca tccagattcg   450540
ccaaatcaga tttcagatat tcaaaatctt aagaagaaag tggatgcagg ctgttcgagc   450600
ctcgtaactc agctcttctt tgacaatgag cgcttctatg attttcagga caagtgtatc   450660
ttggctggga ttgatgttcc cattcatgca ggaattatgc caattctgaa tcgaaatcag   450720
gctctccgac tcttgaagac ttgtgagaat atccatcttc cacgcaaatt taaagccatc   450780
ttagacaagt atgagcatga ccctgagtcg ctcagagcag caggacttgc ctatgcagtg   450840
gaccaaatcg tggacttggt aactcaggat gttgccggtg tgcatctcta tacgatgaat   450900
aatgctgata cagcaaaata catccatcaa gcaacccatg ccttgtttaa tcaccagtct   450960
ctaggataat aaaagcaaac cattcttctc aggtgagggg aatggttcct ttttaatggt   451020
aaagacctca ctttttaaga aaaatatgat aaaataaatt ctgtacgtac ttgatacaaa   451080
gatgaaggta ttaaataata caatgcattt aaactgtaag atttaacgac acgagtgagt   451140
caaatcgatg ttatttgacg agagagttag taaagcattt agctaatcgc ccgatagcga   451200
ttagcgtgaa agctttagat actttagtat taaacctttc taatgatgta tcttgaaaac   451260
tgaacttgcc tacaactctg tggaaaaaga taaatctccc taggagtagt cgctccgtcg   451320
ttcgatttcc tatcttcctt tgagttgctt gacggcttgg tatcttgatg acttgaattt   451380
tggtctcatt tcttaggaaa aaagataagc ttcctagcac tcgtcgagtg cgacgtcacc   451440
ttcctatttt tctacagaaa tgttcggcaa gccgaaccgt ccaaaatatc ttgtgtaatt   451500
gaacacggcc gaaaagctgt gtaaaaaaga taaactgtct tgtcttcatc gaagacttcg   451560
tcagtttcct atttttactt tgcttttgac gtccttggta tcttgatctt tgtaggcaag   451620
gcgtataatt tcatcaatcc aaaggggatt aaaatggcaa aacaagtgtt tcaaacgact   451680
tttgcgggtc gtgagttaat tgtagagact ggtcaggttg ctaagcaagc aaatggatct   451740
gttgtcgtac gttacggtga gtcaactgtc ttgactgctg ccgttatgtc taagaaaatg   451800
gcaactgggg atttcttccc actccaagtc aactacgaag aaaaaatgta tgcggctggg   451860
aagtttcctg gtggctttat gaaacgtgaa ggacgtcctt caacagatgc gaccttgaca   451920
gcgcgtttga ttgaccgtcc gattcgtcct atgtttgcgg aaggtttccg taatgaagtc   451980
caagtcatca atacagtgct ttcttatgat gaaaatgcat ctgcaccaat ggctgctatg   452040
tttggttcat ctttggcact gtctatttca gatattccat ttgacggacc aattgctggg   452100
gtacaagtgg gatatgtaga tggccaaatc atcatcaacc caagtcaaga acaagcagag   452160
caatctcttc ttgaattgac agtagctgga accaagcacg ctatcaacat ggtagagtct   452220
ggtgccaaag aattgtcaga agaaatcatg ttggaagcgc tccttaaagg gcacgaagct   452280
gtcaaagaat tgattgcctt ccaagaagaa atcgttgctg ctgtcggtaa agaaaaagca   452340
gaagtggaat tgcttcacgt ggatgctgaa ttgcaagctg aaatcattgc agcctacaac   452400
agtgacctcc aaaaggcagt tcaagtagaa gagaaattgg cccgtgaagc tgcgactcaa   452460
gtagtgaaag accaagtgac tgccgtttac gaagaaaaat atgcggacca cgaagaattt   452520
gaccgtatta tgcgtgatgt ggctgaaatc ttggaacaaa tggaacacgc agaagtgcga   452580
cgtttaatta cagaagacaa ggtgcgtcct gatggtcgta aggtcgatga aatccgtcct   452640
ttggatgcgg ttgttgactt ccttcctcgt gtacatggtt caggtctctt tactcgtggg   452700
caaactcaag ctctttcagt cttgaccttg gctccgatgg gagaaactca aatcattgat   452760
ggtttggatc cagagtacaa gaaacgcttt atgcaccact ataacttccc tcaatattct   452820
gtaggggaaa caggtcgtta cggtgcgcca ggtcgtcgtg aaatcggtca cggtgccctt   452880
ggtgagcgtg ctcttgctca agtcttgcca agcttggaag aattccccta cgctatccgt   452940
ctagtagcag aagttttgga atcaaacggt tcttcatctc aagcttctat ctgtgcggga   453000
actcttgccc ttatggctgg tggtgtgcca atcaaggcgc cagtagctgg tattgctatg   453060
gggcttatct cagatggaaa taactacaca gtattgacag atatccaagg tttggaagat   453120
cactttggag atatggactt caaggttgca ggtactcgtg atgggattac agcccttcaa   453180
atggatatca agattcaagg gattactgca gaaatcttga cggaggctct tgctcaagcc   453240
aagaaagcgc gttttgaaat ccttgatgtc attgaagcaa ccattccaga agttcgtcca   453300
gaattggctc caactgctcc gaaaattgat acgatcaaga ttgatgtgga caagattaag   453360
attgtcatcg gtaagggtgg agaaaccatc gacaagatta tcgctgaaac aggtgttaag   453420
attgatatag acgaagaagg aaatgtgtct atctactcta gtgaccaaga tgctattaac   453480
cgtgccaaag aaattattgc tggtttggtt cgtgaagcca aagtggatga agtttaccgt   453540
gctaaagtcg ttcgtatcga gaaatttggt gcctttgtta acctctttga taagacagat   453600
gcccttgttc atatctctga gatggcttgg actcgtacca atcgtgtaga ggatttggta   453660
gaaatcgggg atgaagttga tgttaaggtt atcaaaattg atgaaaaagg ccgtatcgat   453720
gcctctatga aggctcttct acctcgtccg ccaaaacctg agcatgatga aaaaggtgaa   453780
aagtctgagc gccctcaccg cccacgtcat caaaaggatt acaaacctaa gaaagaattt   453840
acagaaacat caaaagattc agaataagaa aaggagaaat gtatggggtg gtggcgcgaa   453900
accattgata ttgtaaaaga aaatgatcca gcggcccgca ccactttgga ggttttgctg   453960
acttatccag gtgtcaaggc cttggcggcc caccgtctct cgcattttct ctggaagcac   454020
ggcttcaaac tattagctcg tatgtacagt cagttttggc gcttttggac tcagattgag   454080
attcatccag gagcccagat tgattcaggt gtttttattg accatggttc tggtctggtg   454140
attggagaga cagcgattgt tgaaaaaggc gttcttctct atcacggagt gactctcggg   454200
ggaacaggga aagactgtgg caaacgccat ccgactgtac gaaagggagc cctcatatca   454260
gcccatgccc aagttatcgg gcctgtggaa attggtgaaa atgccaaggt cggtgctgca   454320
gcagttgtcg tagcagatgt acctagtgac gtgacggttg tcggtattcc ggccaagatt   454380
gtccgtcttc atggtaagaa agatgagcct gtcattcacg aagtcgaaga aaaacgagag   454440
tattatgtca ataaactcga gcaggctaaa gatgccagtc acagatcgtc tggtttgtag   454500
aggataccta tatgattcaa gcaagaaaca agttaagcca agaggagcta tctgaggcga   454560
aaaaagtaat taactgttgc caaaactatg acggtaccta tcgcgatccc tatctctcta   454620
acatgcttaa ttttgaccca aacatgcccg cctttttcct ttattatgaa aaaggcgaac   454680
ttgttggttt attaactgtc tatgcagatg accaagatgt agaagtgacg atactggttc   454740
atccaggtca tcgccgtcag gggattgcgc gtgcattgtt tactagtttt gagagagaaa   454800
cagcttcttt ccccattcgg tcagtcactt ttcagacaga acgtattttt ttagagaatc   454860
atcctgactt tgccagtaac tggggactaa tcgaggatga agagacagaa acttggttag   454920
gtaaggatag aagaccttat ccgttagcaa atgtttccca tcttgaagtt ttgttagcag   454980
atagttcgta tcaggatcaa attagtcaat taaaatttca ggcattttca gaggaacatg   455040
aatcgagaga agttgtggat agatatgtcg ctgaagctct gaaagatcca gaaagccgac   455100
tatatatttt attaaaagct ggtcaggtta ttggaacttg tacggttgat ttatcgacta   455160
atacgaatta cctctacggt ttagcaatat tggaacctga acgtggaaaa ggctatggaa   455220
gctacttagc aaaatccctc gtcaaccaac taattgagca aaatgacaag gaatttcaga   455280
ttgcagtgga agatagcaat gtaggtgcca aacgtttgta tgaaaaaatt ggctttgtca   455340
aacagactca ggtggtttat ctgaatgaga aaggagcaag ggattccgaa gtgtagagat   455400
attcggactg aaatttactt gaacttttag tgatgaaact aattgttctt ggatttcagc   455460
tttcctgatt atgatttatg attaaaatct atgacaccat gtctcgtgat ttgcgagaat   455520
ttgtcccgat tgaggacggc aagatcaaga tgtatgtttg tgggccaacg gtgtacaact   455580
atatccacgt aggaaacgcc cgttcgacgg tagcttttga tacgattcgt cgctattttg   455640
agtaccgtgg gtataaggtt gcctatattt ccaattttac agatgtggat gataagatta   455700
tcaaccgtgc cagggaagaa ggtatcacgc ctcaggaggt tgcggataag tacatcgctg   455760
cctttcgtga ggatgtgacg gcattgggcg tgaaacctgc gactcgccat ccgcgtgtag   455820
tggagtttat ggcagacatc atccgttttg tggaagactt gatcgagaaa ggctttgcct   455880
atgagagtca aggggatgtc tatttccgtg tagaaaaatc ccacaactat gctaaattgg   455940
ctaataaaac cttggaagat ttggagctag gtgcttcagg tcgtaccgat gaagaaacgg   456000
ctcgtaagga aaatcctgta gactttgctc tatggaaatc ttccaaacca ggtgagattt   456060
cttgggatag tccttgggga cctggacgtc cgggttggca tattgagtgt tcagtcatgt   456120
cgacagagat tttaggtgat accattgata tccacggtgg tggagctgac ctagagtttc   456180
cacaccacac caatgaaatt gcccagtctg aagctaaaac aggcaaggct tttgctaact   456240
actggatgca caatggcttt gtcaatatcg acaatgtcaa aatgtctaag tccttgggta   456300
acttcattac ggtacacgat gcccttaaaa ctcttgatgg gcaagtactt cgtttcttct   456360
ttgcgaccca gcactaccgt aagcctatca acttcacgga aaaggcagtt cgcgatgccg   456420
agaccaatct caagtatctc aagaatactt acgaacaacc atttacagga aatgtggatg   456480
cccaagagtt acaaaacttt aaagataagt ttgtagcagc tatggatgaa gattttaatg   456540
ctgccaacgg tatcacagtt gtctttgaaa tggccaaatg gatcaactca gggaactatg   456600
atgcaagtgt caagcaagct cttgcagata tgttagaaat ttttggaatt gtctttgttg   456660
aggaagtttt ggatgcagag attgaagact tgattcaaaa acgccaagag gcgcgtgcca   456720
atcgtgactt tgcgacagca gaccaaatcc gtgaccaatt ggttactcaa ggaattaagc   456780
tccttgatac caaggatgga gtgaggtgga cacgtgattg atgtcaatct cattaacggg   456840
attgcgctag cctttgaggg ggatgcggtg tattctatgt atattcgccg tcacctcatc   456900
ctcaaaggta tgaccaaacc caataaactc catcaagaag caactaagta cgtgtcagcc   456960
aaggctcagg ctcgcctgat tgctctcatg ttggaggagc aggtcctaac ggaaaaagaa   457020
gaagaaatct acaaacgtgg ccgcaatacc aatagccaca caaaggctaa aaatgcagat   457080
gtcgtgactt atcgtatgtc cacgggattt gaagcggtta tgggctatct ccatatgact   457140
gagaatctgg aacgtcttga gagtttggtt tcatggtgca tccaaaaagt ggagggctag   457200
aacatgaggg caaaagaact acaagactgg tttcctgagg ctcggatttc agaccaacca   457260
gtagagaaag agggctatct cacgctccct ttagcttctc agcagtggat tttgctggag   457320
gaagctgggc tcagcgagcg tgaaaagcag ttggttgccc ttttgaccca gcaggagcag   457380
gctcgttcgc taaacccttg gtattcctat ctggttgagg gcaagggaca ggcaccgcaa   457440
gtttttaaaa agattcagtt ggtttattgc catctttctt attttcagca ggaaaatctg   457500
gcttcttggc tagatatgat gcggactctt tttccgaatt gtcagacagt gctacaggtc   457560
ggagctcagg attatgtttt cgtgcttcaa caagacaaat acacttctgt aagagatatt   457620
ttaagtgata cgattgaagc ggttgagtat gactttggac ttcgtctttc tatcatgttg   457680
ggtcaggttt ggtctcagac gggacatcaa gccctatcag acttaatcaa agctgagcgg   457740
gatttgttca agacatggtg gcgtcagggt caccaaggtg ttcatacttt ttctcagctc   457800
tatctttgga gtatgggaga aagactcgtg gacttgaagc caatcaagga atgtctacac   457860
cagatgattt tggatcaaga tcagattcag gaaatcattc tctctctttg ggaaaatagt   457920
gctgttctca ctaaaacagc ccagcaactc tatctgcacc gcaattctct ccaatacaag   457980
attgataaat gggaagagtt gacagggctt cagttgaaag agttgaccga cctgaccttg   458040
tgttatcaat tgattttagg ttctttgtca actatagttg gtttgtaaag aagttaatat   458100
ttggagaaga ggattgccat cttctccatt tttatgtgca gagttatagt ggcttgatgc   458160
tgggaaagta cactgtgact gctaaaacat tcctagaagc tgctttgatt tccctaatct   458220
atttatgcaa attttatgtt attttactat aacagttgtt gctaagccaa ataatagtgg   458280
ggaagttcat ttagacgtaa gcattgaaga taatcaggga ggtagtgggt ataatttcag   458340
ttctgtttca agtagctcac aaacagctaa atatgaagga actgtttata ataacaattc   458400
atcattatat ataacgattg ataaaacgtc tgatgcaaca gctcttttga aattaaagtt   458460
gaataatgtt gataatcaac ctgctactga agttcctagt tcaggaatta ctgtaaaatt   458520
aaatgctaaa gataatgctg gaaactggac aagtgcttcg aataaaaaag aagtaacagt   458580
aaaaattgtt tctgctaaac cgacatatcc agacaaaatc ttagtgaaaa atcctgataa   458640
tataaaagat acagaaaaaa tgccattatt gaaaaattga aagaggcaaa taaaaatcat   458700
ccagcaggag ctccaacctt tgctaaaggt gaaggagagc atgcaaatga tattgtagca   458760
acttattcag atggtacaac ttattatgta ccgttaaatg atgtgacaaa atatgcgagg   458820
tagtggctgt accactcact tattcacctc cccgtgattt gtagtagtga taggttttct   458880
cactattatt ataaaacaaa ataaagatca caacactttt tcattctgtg ttgtgccttg   458940
agtgaaacga aaggaatgaa ttataaatat gaaaagtata gtcactagca tagatgagcg   459000
cttgcgtact cgcctacgag tgattatctg gaagcaatgg aagaagaaat cgagacgatt   459060
atggggattg cttaagttag gggttcctaa atggatagca gataaggtat ctggctgggg   459120
cgaccactat caattatagt aaaatgaaat aagaatagga cgaattgttc aggacagtca   459180
aatcgatttc taacaatatt ttagaagtag aggtgtacta ttctagtttc aatctactat   459240
agtagctcag aagtcggtac ttaaacgtgc tatatcaaaa ccagtccttg aaaaacgtgg   459300
actggtttcg tgtttggatt attaccttga acgacatgcg ttaaaagtta gttgaaccgc   459360
cgtatgccga acggcacgta tggtggtgtg agaggggcta gagattatcc cctactcgat   459420
attttttttt cgtatttcat aaatatttca tatttgggtt ttataatagt cttacaaata   459480
tggaggtgac aaatgaatcc aatccaaaga tcttgggctt atgtcagcag aaagcgactg   459540
agaagtttta ttttatttct gattttattg gtcttattgg ccggaatttc agcctgtttg   459600
actctgatga agtccaacaa aacagtagaa agcaatcttt ataaatcact caatacatct   459660
ttttctatta agaagataga gaatggtcag acattcaagt tgtcagacct agcatctgta   459720
agcaagatta aggggctgga aaatgtctct cctgaacttg agacggtcgc aaaactaaaa   459780
gacaaggaag cagtgactgg cgagcagagc gtggagcgtg atgatttatc agctgcagac   459840
aataacttgg ttagcttaac ggctcttgag gattcatcca aggatgtaac ctttaccagt   459900
tcggctttca atctaaaaga agggcgacac cttcaaaaag gggattccaa gaaaatcctt   459960
atccacgaag aattggctaa gaagaacggt ctttcgcttc atgacaagat tggcttggat   460020
gctggtcagt ctgaatctgg aaaaggacaa acagtagagt ttgagattat cggcatcttt   460080
tctggtaaaa aacaagagaa attcacaggc ttgtcttctg acttcagtga aaatcaagtc   460140
tttacagact atgaaagtag ccaaaccctt ttgggcaata gtgaagctca agtcagtgca   460200
gcacgcttct atgtagaaaa tcctaaggaa atggacggac tcatgaagca ggtagaaaac   460260
ttggccttgg aaaatcaagg ctaccaagtc gaaaaggaaa acaaggcttt tgaacaaatc   460320
aaagactcag ttgcaacttt ccaaaccttc ctgaccatct tcctttatgg gatgttgata   460380
gcaggagctg gagccttaat tctggttttg tctctctggt tgagagaacg ggtctatgaa   460440
gtggggattt tacttgcact tggaaaaggc aagagctcga tcttcctaca attctgttta   460500
gaggtagttt tggtatctct tggagctttg cttccagcat ttgttgcagg aaacgcaatc   460560
acaacttacc tactccaaac tctactagca agtggagatc aggcaagctt acaagataca   460620
ctagccaaag caagcagttt atcaactagc atcttatctt ttgcagaatc ctatgttttt   460680
ctagttctgc ttagttgctt atctgtagcc ctttgtttcc tattcttatt tagaaaatca   460740
ccgaaagaaa ttttatcatc tattagttaa gaaggagaaa tcatgacttt attacaatta   460800
caagatgtta cctaccgtta taagaatact gctgaagcag tcctatatca gatcaattat   460860
aattttgaac ccggaaaatt ttacagtatt attggggagt caggagcagg aaaatccaca   460920
ctcttgtccc tacttgctgg tctagatagt cctgttgaag gttctatcct ttttcaagga   460980
gaggatattc gtaagaaggg ctattcttac catcgcatgc accatatttc cctggtcttt   461040
caaaattata acttgataga ttatctttct ccgctggaaa atatccgatt ggtcaacaaa   461100
aaggcaagca agaatacact tcttgagctt ggtttggatg aaagccagat caagcggaat   461160
gttctccagt tatcaggtgg tcaacagcaa cgtgttgcca ttgctcgcag tttggtctca   461220
gaagctccag ttattctagc tgatgagcca acaggaaatc tggatcctaa aactgctgga   461280
gatattgtcg aactactcaa atcacttgcc cagaaaacag gtaaatgtgt gattgtcgta   461340
actcacagta aagaagtggc acaagcgtca gatattacac ttgaattaaa ggataagaaa   461400
ctgactgaaa cgcgcaatac tagtaaataa tttgagctta ttttaataga atgattaaaa   461460
caaaatctag aaagggaatc tatgttacac aacgcatttg cctatgttac aaggaagttt   461520
ttcaaatcga ttgtcatctt cctgattatt ctcctcatgg cgagcttgag tttggtcggc   461580
ttgtcaatca agggagctac tgccaaggct tctcaggaga cctttaaaaa tatcaccaat   461640
agcttctcca tgcaaatcaa tcgtcgcgtc aaccaaggaa cgcctcgtgg tgctgggaat   461700
atcaagggtg aagacatcaa aaaaatcacc gaaaacaagg ccattgagtc ttatgtcaaa   461760
cgtatcaacg ctatcggaga tttgactgga tatgacctga ttgaaacgcc agaaaccaag   461820
aagaatctca ctgctgatcg tgccaagcgt tttggaagta gcttgatgat tacaggtgtc   461880
aatgactcct ctaaagaaga caagtttgtc tctggttctt ataaactagt cgaaggagag   461940
cacttaacca acgacgacaa ggataaaatc ctcttgcaca aggacttggc agccaaacac   462000
ggctggaaag taggggacaa ggttaaactg gactctaata tctacgatgc agataatgaa   462060
aaaggagcca aggaaacagt tgaagtgaca atcaagggac tctttgatgg tcataataag   462120
tcagcagtaa cctactcaca agaactttac gaaaacacag ctattacaga cattcacact   462180
gctgcaaaac tttatggata cacagaagac acagccattt atggggacgc aaccttcttt   462240
gtaacagcag acaagaactt ggatgatgtt atgaaagagt tgaatggcat cagtggtatc   462300
aactggaaga gctacacact cgtcaagagc tcctctaact acccagctct tgagcaatct   462360
atctctggta tgtacaagat ggccaacctc ctcttctggg gtagcttgag cttctcagtt   462420
ctcctccttg ccctcttgct cagcctttgg atcaacgccc gtcgcaagga agtgggaatt   462480
ctcctctcta tcggcctcaa gcaggcaagt atcttgggtc aattcatcac cgaatctatc   462540
ttgattgcta tccctgctct agtttctgct tacttcctag ctaattacac tgcccgtgca   462600
attggaaaca ctgtccttgc caatgtgact tcaggtgttg ccaaacaggc tagtaaggcg   462660
gctcaagcct ctaaccttgg tggtggtgca gaagtagatg gctttagcaa gaccttgtcg   462720
agcctagaca tttccattca gacatcagac tttatcatca tttttgtcct tgccttggtt   462780
ctagtggttc tcgttatggc gcttgcttca agcaatctcc ttagaaaaca accaaaagag   462840
ctcttgctgg atggtgaata aatttgaaaa aatgagtcta gaataaagat tgcatcttgt   462900
gtttctattc aagaatagtg gataggaatg gctatttaac aattcaaaat aaatccgaaa   462960
gcagtggtga aaatcattgc tttcagttgc tttctttgta ctttagtgct taaatataat   463020
atactaaagt tatggaattt atgagaaagg aatttcacaa cgttttatct agtggtcagt   463080
tgcttgcaga caaaaggcca gcaagagact ataatagaaa atagggtagg tatttattct   463140
aagaaaaata aaaaatagag agcagttaaa gtatgaaaat tttaattgta gaagatgaag   463200
agatgatccg tgagggggtc agtgattatt tgacggattg tggctatgaa actattgagg   463260
cagcggacgg tcaggaagct ctggagcaat tttctagcta tgaggtggcc ctggttttac   463320
tggatatcca gatgcccaag ctcaacggct tagaagtcct agctgagatt cgtaaaacca   463380
gtcaggttcc tgtcttgatg ttgacagctt ttcaagatga ggaatacaag atgagtgcct   463440
ttgcctcttt ggcagatggc tatctggaaa aacctttctc cctctccctt ttaaaagtga   463500
gggtggacgc gattttcaag cgctactacg atacaggacg aatcttttct tacaaggata   463560
ccaaggtgga ctttgaaagc tacagtgcaa gcctcgcagg tcaagaagtg cctatcaatg   463620
ccaaagagtt ggaaattctg gactatctag tgaaaaatga aggccgggcc ttgactcgat   463680
ctcagattat cgatgccgtc tggaaagcga cagatgaggt tccctttgac cgtgttattg   463740
atgtttatat caaggaattg cggaaaaagc tagacttgga ttgtatcctc actgtgcgca   463800
atgttggtta taaattggag cgaaaatgaa acgaacaggt ttatttgcaa agatatttat   463860
ctataccttc tcgatattta gtgttctggt tatctgcctt catttagcta tttattttct   463920
ttttccttcg acttatctga gtcatcgtca ggaaaccatt ggtcaaaagg caacagccat   463980
tgcccagtcc ctagaaggga aagataggca gagtatcgag caagtgttag acttgtattc   464040
ccagactagt gatatcaagg ggaccgtcaa aggtgagatg accgaggaca agttagaagt   464100
caaggacagt cttcctctgg acacagaccg ccagacaacc tctctcttta ttgaggagcg   464160
cgaggtgaaa acgcaagacg gtggtactat gattctccag tttctagctt ccatggattt   464220
acaaaaggaa gcggagcaaa tcagtctcca gtttcttccc tataccttgc tggcctcctt   464280
tctgatttcc cttttggtgg cctacatcta cgctcggact attgttgcac cgattttgga   464340
aatcaagcgg gtgacccgtc ggatgatgga cctggattcc caagtgcgat tgcgcgtgga   464400
ttctaaggat gagataggta atctcaagga acaaatcaat agcctctacc agcatctctt   464460
gactgttatt gcggacttgc atgaaaagaa tgaagccatt ctccagctgg agaagatgaa   464520
ggtcgaattc ctacgaggag cttctcatga attgaaaaca ccgctggcta gtttgaaaat   464580
cctaatcgaa aatatgagag agaatatcgg tcgttataag gatagagacc agtatctggg   464640
agttgccttg gggattgtgg atgaactcaa tcaccatgtt ctgcagatac tttccctctc   464700
ttctgtgcag gaattgcgag atgataggga aacaattgac ctcctccaga tgacgcaaaa   464760
tctggtcaaa gattatgcct tgctagccaa ggaaagagag ctccagatag acaatagttt   464820
gacccatcag caggcttatc taaacccatc agttatgaag ttgattcttt ctaatctcat   464880
cagcaatgcc attaagcact ctgttccagg tggcttagtt cgaattggag aaagagaagg   464940
agaacttttt atcgaaaata gctgtagctc agaggaacaa gaaaaactag cccagtcttt   465000
ttctgacaat gccagtcgca aggtcaaggg gtctggtatg gggctctttg tggttaagag   465060
tctattagaa catgaaaaat tagcttatcg tttcgagatg gaggagaata gtttaacctt   465120
ctttatagat tttccaaaag tcgtccaaga ctagggagag aaagggttta catagatgga   465180
gttagaagaa aatcaatcga aactgcggga aaaactagat ttttttggca aaaagtgata   465240
aaatgaacaa tgtaaatggg atgacccata aaaatataca ggaggcctga taaaatggca   465300
atcgtttcag cagaaaaatt tgtccaagca gcccgtgaca acggttatgc agttggtgga   465360
tttaacacaa acaaccttga gtggactcaa gctatcttgc gcgcagcaga agctaaaaaa   465420
gctccagttt tgatccaaac ttcaatgggt gctgctaaat acatgggtgg ttacaaagtt   465480
gctcgcaact tgatcgctaa ccttgttgaa tcaatgggta tcactgtacc agtagctatc   465540
caccttgacc acggtcacta cgaagatgca cttgagtgta tcgaagttgg ttatacttca   465600
atcatgtttg acggttcaca ccttccagtt gaagaaaacc ttaaattggc taaagaagtt   465660
gttgaaaaag cacacgctaa aggtatctca gtagaagctg aagttggtac tatcggtggt   465720
gaagaagatg gaatcatcgg taaaggtgaa ttggctccaa tcgaagacgc taaagcaatg   465780
gttgaaactg gtatcgactt cttggcagct ggtatcggta acatccacgg tccttaccca   465840
gtaaactggg aaggtcttga ccttgaccac ttgcaaaaat tgacagaagc tcttccagga   465900
ttcccaatcg tattgcacgg tggatcaggt attcctgatg agcaaatcca agcagctatc   465960
aaacttggtg ttgccaaagt taacgttaac acagaatgcc aaatcgcatt cgctaacgca   466020
actcgtaaat ttgctcgtga ctacgaagca aacgaagcag aatacgacaa gaaaaaactc   466080
ttcgacccac gtaaattctt ggctgacggt gtaaaagcta tccaagcatc ggttgaagaa   466140
cgtatcgacg tattcggttc agaaggtaaa gcataatcta gctgaataat acagataaaa   466200
cctgcctgtg agggtgggtt ttttgatttc aagctactcg ttttagtata gtaaactgaa   466260
tctagactag cacaatgctg cttctatagc gttttgaaac tagaatagga taacataact   466320
gctaaaagat ttctataaat tcatttgatt ttcctaatca atttgttcgt atcctatttc   466380
actccactat aaaatagtct tatcaattga tttgaatgcc aaaattccat cgttcctgtc   466440
ttatttcatt tggctataaa aaactctcct gggaaatccc aggagagtat gattacttat   466500
ttgaacttga atccttcgta aataagctct gtttttggat tttgtttctt aatctgtttg   466560
gcaagtgcct tcatcataga aataggacca cacatataga cggttgcatg ttcgggcact   466620
tctttttgtt caaaattaag atagccgtct ttcgtactgt cgattagatg gagttcaaaa   466680
ttaggatttt tctgagcata gttacggagt aaatctaggt agactgcatt ttcatctcca   466740
cggaagctat agtagaagtg aacctgttta tctaaaatag gatgttcacg gatgtaagag   466800
atgaaggggg tgatcccaat acctccagca atccaaacct gattttctcg tccttcttct   466860
atgatcatgt gtccgtaagc tctgtctagg gttactttgc tgccggcttg aagattatca   466920
tagatattct tggtatggtc gcctgaagtt ttaacagtaa agtaaagagt ttgaccatga   466980
cctcctgaga tagaaaaggg atgcggagca ctttcaaagc cttcttggaa aatctttaga   467040
aaggcaaatt gtcctgattg atagttgaaa ggtctgctaa gatggatttg aatttctcta   467100
gtatcgtgat ttaagcgttt gagatgggta attttcccta gataggggaa ggaaatcttt   467160
tgatatagaa aaatgatata aaaaccagct agtaagccta aaagggcata gctaccaaca   467220
agaaaactta gaagattaaa tgtaaggaga cgattgccca ttatcatgta gatgtgaaag   467280
agtcctaaaa tataggctag gtaaaccagg cggtgaatcc atcgccaagc ttcgtattgg   467340
atgtatttgc ctaaataggc gacaaggatg atgctggcaa agatatagat ggcaagattg   467400
ccaaactgag cagctaagcg agagccccac aaaccgccca tactaaagtt atgaaagatt   467460
agtaggatga ttgagagaaa ggctgtgaat ttgtggacgg tgtagacctt ctccaaactg   467520
tgaaaccagc tttctagtag tgggagacga gtggctagga taaaagtcag agataggctt   467580
gttaaagcta gtcctggaat catgaattgg ggagaagtgt tcatccaagt caaaagagtc   467640
aagataaaac tagctatgat aaagagtagt cctttgactg atttcataga aaattccatt   467700
tcatttagat ttcgatttgt tgtaaataaa tttgttacat tttatcatag aaaatgtatg   467760
gtgtcaaatt gaggtctata aatatctact ctcatcaaaa aactctccaa ttgaactgga   467820
gagtggctgt ttatactcaa tgaaaatcaa agagcaaact aggaagctag ccgcaagttg   467880
ctcaaaacac tgttttgagg ttgcagatag agctgacgtg gtttgaagag attttcgaag   467940
agtgttattc tgcagcttgt tgccaacgtt tggctagcat atgagacagg ctagaaattg   468000
ctaggttaaa gctgaagtag atgagggcaa tcaggatgta aagactgaag acctgctctg   468060
gttcgaaata acggcccatg agaatttggc tggctccaaa gagttcttgt agggcgataa   468120
cagagtagag gagactggta tccttaatca cggtaacaaa ctgagaaatg atggctggta   468180
gcattttgcg gatggcttgt gggagaatga tgtagtagag gatttgggct gaggtgaagc   468240
cttgtgacat tcctgcttcg tactgtccct tgtctacggc attgagaccg cctcgaataa   468300
tctcagccaa ggctgctgat gtaaagagag taaaggctgt aatacctgct ggtgtggatt   468360
tcattttgaa caccaaaaag atagtaaaaa tccagagaag gttgggaacg ttgcgcacaa   468420
actcgatata aatactggaa ataatgcgta agacaggatt tttgccattt ctcgtgacag   468480
ctagcaccgt accgatgata gtagagagga tgatggcaat cagagaaata tagagggtca   468540
agccaaatcc tttaaagata aagactaggt tatctggggt taaaacttct aaaatagatt   468600
ccatagtaac ctcctaaagt gaataggctt ttttgttggc ttgctccatc ttgcgaccaa   468660
actgggcaac agggaagcat agagcaaagt agagaagagc agcacctaaa aaggctggta   468720
tatagtttcc gttgagagcc gaccaagact tagtcacaaa catcaagtct actccagaga   468780
tgatagctac agtagaggtg ttcttgatga ggttaacaat ttggttggtc aatggaggga   468840
gaatgatgcg gaaggcctga ggcaagataa tcaagcgcat ggcactgata taggtaaaac   468900
cttgcgacaa ggcggcctcc atctgaccac taggaataga ctgaatccct gaacgaataa   468960
cctcagcgat ataagcgccg tgatagagtc ccacgcagag aacggctgtc caataaattg   469020
gaatcatgat gatatggtca ctgataagag gtaggccata aaaaacaata acaaactgca   469080
ccaagagggg agtattttgg taaaattcaa caaagatgcg agctaaaatg cgtaaaattg   469140
gacgtttact ggttgacatg gcaccaaaga agatgcccaa aaccatagcg aggataaagg   469200
aaccaaccgc tagggcaagg gtgaagagga aaccattgaa aaattgtcca aaatcctgaa   469260
aataggctgt ccaagatgat aaatctgtca tggggtgtcc tccttaatct gcagtatggc   469320
tagatggttt gagcttgtaa cggtcataaa gtttctgcaa actaccatcc ttgctccatt   469380
tagtaaccaa gttatcaaga tagtcgttga gctctgtatt tgatttcttg gtaacaatac   469440
cgtagtcaga tggcttgaaa ctatcatcta gtagtgctgt ccgtttacta gtgtagccag   469500
atagaataga gcggtcaacg gaaaaggtat cgatacgatg agcgtgcagg gaagtaatca   469560
attctgggta ggaaccaagt tcgacgaatt taaacttcag acctttcttt ttacccagtt   469620
cagtaatcag gcgttgggtg atagaacctt gggcgactcc gatggttttg ccgtttaggt   469680
cctcaatctt tttgattttg gcagatttat tgaccaaaaa tccagaagcg tctgtgtagt   469740
agggactggt aaagttgtag agttttttgc gttcgtccgt gatggtaaag gtcgcgatat   469800
ccatatcgac ctgttcattg tctagaaggg ggccgcgggt ttgtgctgta accggcacat   469860
agcgaatctt gaccttgagt tcatcagcta ccatcttggc caagtcggtt tcgataccag   469920
aataagtacc ggtcttggga tctttgtaac caaaattggg aacgtcttgt ttgacaccga   469980
caaccagttc gcctcttttt tgaatgtctg cgatacttgt atcagcctgg actggtttgg   470040
cagcagcaag gccgaaaagg ctaatcaata atgctgataa aaagaatttt ttttcatagg   470100
cgcctcctta tttgactttg tcactttcgt ggttgataat tttgctgagg aattgttggg   470160
cacgaggttc gcttggattg tcaaaaaagt tatcgacatc tgtcgtatct actaaaactt   470220
ctccgtcggc cataaagata atgcggtccg caacctctcg agcaaagccc atttcgtggg   470280
taacgatgat catgttcatc ccatcatgcg ccagtttctg cataactgct agaacatctc   470340
cgatagtctc aggatcaaga gcagatgttg gttcatcaaa gaggaggagt tccggatgca   470400
tagcaagacc acgagcgatg gcgatccgct gtttttgtcc accagatagc atggcgggat   470460
aggaatcttt cttgtcccac atatttacaa attccagata tttttgggcg gttttttcag   470520
cttctttttt atcaattcct agaacttcaa tgggtgcaag cgttacgttt tctaacacag   470580
ctttgtgtgg ataaaggtta aaatgttgaa aaaccatgcc gacttccttg cgaagaggta   470640
ccaaatcttt ctggctggca ccagcaactt ggtgcccatt gactaggaga cttcctttgt   470700
caacagtctc taaaccattg atcgtacgga taagagtgga cttcccagag ccagaaggtc   470760
caagcaggac aacaacttgt cctttttcaa aacggagatt gatgttgcgg aatgcgtggt   470820
agtctccgta atatttttcg acgtttttaa attctactaa agccatgaga gatctctatt   470880
gtgttatatt ttataacacg gttctacaat aaaagaatgt tcttgtcaaa tcatatctga   470940
aaaaattcac tatagtgaaa taagaacagg aaaaatcgat cgggacagtc aaatcgattt   471000
ctaacaatat tttagaagta gaggtgtact attctagttt caatatacta taaaatgtta   471060
taaaaaagca atctggatag agaaaacgtc taaatcatgt tataatgaag caatagaatt   471120
cttagaaaga gtggatgtct ttttgataac acctacttat gaatggcagt ttgccctgca   471180
ggtagaagat gcggatttta caaagatagc caagaaggct ggactgggtc ctgaggtggc   471240
tcggttattg tttgagagag ggattcagaa ccaagaaagt ctgaagaagt ttttagaacc   471300
ttccttggag gacttacatg atgcttatct gctccatgat atggacaagg cagtggagcg   471360
gattcgtcag gctattgaag aaggggaaaa tattcttgtt tatggagact atgatgcgga   471420
tggcatgact tcggcttcta ttgtgaagga aagtttggaa caacttggtg ctgagtgccg   471480
agtttacctg ccaaatcgtt ttaccgatgg ctatggccct aatgctagtg tttataaata   471540
ctttatcgag caagaaggga tttccttgat tgtgacggtg gacaatgggg ttgctggtca   471600
tgaggctatt gcattggctc agtctatggg agtagatgtc attgtgacag accatcattc   471660
catgcctgaa accctgccag atgcttatgc tattgtccat cctgaacatc cagatgcgga   471720
ttatcctttt aaatatttgg ctggttgtgg agttgctttc aagttggctt gtgccctgtt   471780
agaagaagtg caagtggaat tgcttgattt ggtcgctatt ggaactattg cagatatggt   471840
gagtctgacg gatgaaaatc gtatcttagt tcaatatggt ctggaaatgt tgggtcatac   471900
ccagcgcatt ggtctgcaag aaatgctgga catggctggg attgctgcca acgaagtaac   471960
agaagaaacg gttggtttcc agattgctcc tcgtttgaat gccttgggtc gcttggatga   472020
tcccaatcct gccattgatt tgttgactgg atttgatgat gaggaagcgc atgagattgc   472080
ccttatgatt caccagaaaa acgaagagcg caaggaaatc gttcagtcta tctatgaaga   472140
agccaagacc atggtggatc ctgagaagaa ggttcaggtc ttggccaagg aaggctggaa   472200
tcctggggtt ctaggaatcg tggctggtcg tttattggaa gaattgggac agacagtcat   472260
tgttcttaat atagaagacg gtcgtgccaa gggcagtgct cgtagtgtgg aagcggtcga   472320
tatttttgaa gctctggatc cccatcgaga cctcttcatc gcctttggag gtcatgcagg   472380
tgcagcgggt atgacgctgg aagttgagca actctcagat ttatctcagg ttttggaaga   472440
ttatgttcgt gaaaaaggtg cagatgctgg tggcaagaat aagttaaacc tagatgaaga   472500
gttggatttg gaggcactta gcttggaaac ggtcaaaagt tttgaacgtt tagctccttt   472560
tggaatggat aatcagaaac ctatttttta tatcaagaat tttcaggtcg aaagtgctcg   472620
tactatgggg gcaggtaatg cccatctaaa gctgaaaatt tccaagggtg aggcgagttt   472680
tgaagtggta gcctttggtc aaggcagatg ggcgacagag ttttctcaaa ccaagaatct   472740
agagttagcg gttaaattgt ctgtcaacca atggaatggc caaactgccc tccagttgat   472800
gatggtggat gcgcgagtgg aaggtgttca actttttaac attcgtggaa aaaatgcagt   472860
cttgccagaa ggtgttccag tcttggattt tcctggagaa ctgccaaatc ttgcggctag   472920
tgaagctgtt gtcgtaaaaa acattccaga ggatattact cagctgaaga ccatttttca   472980
ggaacagcat ttctctgctg tctatttcaa aaatgatatt gacaaggctt attatctgac   473040
aggttatggg actagagatc agtttgccaa attgtacaag actatttacc agttcccaga   473100
gtttgatatt cgctacaagc tgaaagattt ggctgcatat cttaatattc aacaaatctt   473160
gctggtcaag atgattcaag tatttgaaga actaggcttt gtgacgataa aagatggtgt   473220
gatgacagtc aataaagagg cgccaaagcg ggagatagga gaaagtcaaa tttaccaaaa   473280
tctcaaacaa accgttaaag accaagaaat gatggcgctg ggtacggtgc aagaaattta   473340
tgattttttg atggaaaaag agtagaagtt aggaaagagt tgggaaatca actctttttt   473400
gaaaacagac cttcattttg aaaatcatca aaaaaatggt ataatggtag gaaaagattc   473460
ggctgaaagt atcagaactt ttagaataag agggtagaat tgccctataa tcaagataaa   473520
ctaagatttt ggaggaaaaa tgagtaatat cagtttaaca acacttggtg gtgtgcgtga   473580
gaatggaaaa aatatgtaca ttgctgaaat tggagagtcc atttttgttt tgaatgtagg   473640
gttaaaatat cctgaaaatg aacaattagg ggtcgatgtg gtgattccaa acatggatta   473700
cctttttgaa aatagcgacc gtattgctgg ggttttcttg acccacgggc atgcggatgc   473760
cattggtgct ctaccgtatc tcttggcaga ggctaaagtt cctgtatttg ggtctgagtt   473820
gaccattgag ttggcaaagc tctttgtcaa aggaaatgat gccgttaaga aatttaatga   473880
tttccatgtc attgatgaga atacggagat tgattttggt gggacagtgg tttccttctt   473940
ccctacgact tactccgttc cagagagtct gggaattgtc ttgaagacat cggaaggaag   474000
catcgtttat acaggtgact tcaaatttga ccaaacggct agtgaatctt atgcaactga   474060
ttttgctcgt ttggcagaga ttggtcgtga cggcgtcctg gctctcctca gtgattcggc   474120
caatgcagac agcaatattc aggtggctag tgaaagtgaa gttagggatg aaattaccca   474180
aactattgct gactgggaag gtcgtatcat cgttgcagct gtttccagta atctttctcg   474240
tattcagcag atttttgacg ctgcggataa aacaggtcga cgtatcgtct tgacaggatt   474300
tgatattgaa aatatcgtcc gcacagcgat tcgtcttaag aagttgtctt tagccaacga   474360
aattcttttg attaagccta aagatatgtc tcgctttgaa gaccatgagt tgattattct   474420
tgagacaggt cgtatgggtg agcctatcaa tggacttcgt aagatgtcga ttggtcgcca   474480
tcgttatgta gaaatcaagg atggggacct agtctatatt gctacggctc cgtctattgc   474540
taaagaagcc tttgttgcgc gtgtggaaaa tatgatttat caggcaggtg gggttgtcaa   474600
attgattacc caaagtttac atgtatcagg gcacggaaat gtgcgtgatt tgcagctgat   474660
gatcaatctt ttgcaaccta agtacctctt ccctgtccaa ggggagtatc gtgagttgga   474720
tgctcacgct aaggctgcca tggcagttgg gatgttgcca gaacgcatct tcattcctaa   474780
aaaggggacg accatggctt acgagaatgg agactttgtt ccagctggat cggtttcagc   474840
aggagatatc ttgattgatg ggaatgccat tggtgatgtt ggaaatgttg ttcttcgtga   474900
ccgtaaggtc ttgtcagagg atggaatttt catcgtggct attacagtca accgtcgtga   474960
gaagaaaatt gtggctaggg ctcgtgttca cacgcgtgga tttgtttatc tcaagaagag   475020
tcgcgatatt ctccgtgaaa gttcagaatt gattaaccaa acggtagaag agtatcttca   475080
aggagatgac tttgactggg cagatctcaa aggtaaggtt cgtgacaatc tgaccaagta   475140
cctctttgat caaaccaagc gtcgcccagc cattttacca gtagtcatgg aagcaaaata   475200
atcgttgaaa taaacagaga gaaagtcgag tttcggcttt ttcttataga aaaatagaag   475260
gagaaaatca tggcagtgat gaaaatcgag tattactcac aagtattgga tatggagtgg   475320
ggggtgaatg tcctctaccc tgatgccaat cgagtggaag aaccagagtg tgaagatatt   475380
cccgtcttgt accttttgca cgggatgtct ggaaatcata atagttggct taagcggacc   475440
aatgtagaac gcttgcttcg aggaactaat ctcatcgttg ttatgcccaa taccagcaat   475500
ggttggtaca ccgataccca gtatggtttt gactactaca cggctctagc agaggaattg   475560
ccacaggttc tgaaacgctt cttccctaat atgacgagca agcgtgaaaa gacctttatc   475620
gctggtcttt ctatgggagg ctacggctgc ttcaaactgg ctcttacgac aaatcgtttt   475680
tctcatgcag ctagtttttc aggtgccctc agctttcaaa acttttctcc tgaaagtcaa   475740
aatctgggaa gtccagccta ctggagaggt gtttttggag agattagaga ctggacaact   475800
agtccctatt ctcttgaaag tctggctaaa aaatcggata aaaagaccaa actttgggcg   475860
tggtgtggcg aacaggattt cttgtacgaa gccaataatc tcgcagtgaa aaatctcaaa   475920
aaactaggtt ttgatgtgac ctatagccat agcgctggaa ctcacgagtg gtactactgg   475980
gaaaaacaat tggaagtttt tttaacaacc ctaccaattg atttcaaatt agaagagaga   476040
ctgacttagt ttgaacttca gcataggggg agtagaacta aaataaaata tgttttcact   476100
agacttttca aacgaaagta gtagaatagt aataaaatac tggaggaaag agagtaggaa   476160
atgtaccgtt atcaaattgg cattcccaca ttagaatatg atcagtttgt caaagaacat   476220
gaattagcca atgtattaca aagtagtgct tgggaggaag ttaagtctaa ttggcaacat   476280
gagaagtttg gtgtttacag ggaagaaaaa ttactggcga cagctagtat tttgattaga   476340
actcttccgc taggctataa aatgttttac atcccaagag gacctatatt ggattatggg   476400
gataaagaac tcttgaattt tgccattcag tctattaagt cctatgctcg cagtaagaga   476460
gcggtttttg tgacttttga cccaagtatt tgcctatctc aaagtttaat caatcaggaa   476520
aagacagaat ttcctgaaaa tctggctatt attgatagtt tgcaacaaat gggagtaagg   476580
tggtcaggaa aaacggagga aatgggagac accattcaac ctcgtattca ggcgaaaata   476640
tacaaggaaa attttgaaga agataaactt tccaagtcaa caaaacaggc tattcgaaca   476700
gcacgaaaca aagggcttga gattcaatat ggtggactgg aactattaga ttcattttcg   476760
gagttgatga aaaaaactga gaagcgaaaa gagattcatt tgaggaatga agcctattat   476820
aaaaaattgt tagataattt taaggacaag gcctatatca ccttggccac cttggatgtt   476880
tctaaacgtt cgcaagagtt agaagaacag ttagcgaaaa atagagcctt ggaagagacc   476940
tttactgagt cgactcgaac ttcaaaagta gaagcgcaga agaaggaaaa agaacgtttg   477000
ttagaggaat tgaccttctt gcaggaatat atagatgtag gtcaagcgag agttccttta   477060
gcggctactt tgagtttgga atttggtact acctctgtca atatatatgc tggtatggat   477120
gatgatttta aacgttacaa tgcaccaatt ttaacttggt atgaaacggc tcgctatgcc   477180
tttgaacgag gtatgatctg gcaaaattta ggtggtgttg aaaactctct caatggtgga   477240
ctttatcatt ttaaggaaaa atttaatcca acgattgaag aatacttggg tgaatttaca   477300
atgcccactc atcctctcta tcctctgtta agacttgctc ttgatttccg taaaacatta   477360
agaaaaaaac atagaaagta agtatatggc actaacaaca ctcacgaaag aagagtttca   477420
gacttattct gatcaggttt cttctcgttc ctttatgcaa tctgtccaga tgggggattt   477480
gctagaaaaa agaggggctc gaattgttta tcttgctttg aaacaagaag gagaaattca   477540
agttgcagct ctggtttata gcctgcccat gctgggtggt ctgcatatgg aactcaattc   477600
ggggccgatt tatacccaac aagatgctct tccagttttt tatgcagagt taaaagaata   477660
tgccaagcaa aatggtgtat tagagttgct tgtaaaaccc tatgaaactt atcaaacttt   477720
tgatagccaa ggtaatccaa tagatgctga gaaaaaaagt attattcaag atttgactga   477780
tttaggttat caatttgatg gcttaacaac aggttaccca ggtggagaac cagattggtt   477840
atactataaa gatttaactg aattaactga aaagagtttg cttaaaagtt ttagcaaaaa   477900
gggtaaaccc ttggtgaaaa aggctgaaac ctttggcatt cggttgaaaa agttaaaacg   477960
tgaagaacta tcgattttta agaatataac aaaagaaacc tctgaacgta gagaatatag   478020
tgataaaagt ttagaatatt atgagcattt ttatgatact tttggagaac aagcggagtt   478080
tctcatagca agcttaaatt tttcggacta tatgagcaaa ttgcaaggtg aacaaagtaa   478140
actagaagaa aacttggaca agttgcgact tgatttgagt aaaaatcctc attctgagaa   478200
aaaacaaaat caactgagag aatattctag tcaatttgaa acgtttgaag ttcgaaaagc   478260
agaagcgcga gacttgattg aaaaatatgg agaagaagat attgttttag ctgggagttt   478320
atttgtttat atgcctcagg aaacgactta tctctttagt ggttcctaca ctgagtttaa   478380
taagttctat gcccctgcac tgcttcaaaa atatgttatg ttggaaagca taaaacgtgg   478440
aatacctaaa tacaacttcc taggcattca agggattttt gatggaagtg atggtgtttt   478500
gcgttttaaa cagaatttta atggctatat tgtacgcaaa gcaggtactt tccgttacca   478560
tccatcgcct ttaaaataca aagctatcca gttactcaaa aaaatagtag gacgttaaga   478620
tgaaaaagtc agtatttaga tttcttttag cttcttttag taaaataatt cttatttgct   478680
agaaaggtgg agagacatgc gctggctttt tcgtttgata ggggctttct tttcttttgt   478740
gtggcgtttg ttttggcgtc tggtttggat agttgtgctc ttatgtgtgc ttgctttcgg   478800
acttctctgg tatctgaacg gagattttca aggagcgcta aagcaagcag aacggtcagt   478860
aaaaattggt caacaaagta ttgaccaatg ggagaaaaca gggcaactgc ctaagttaag   478920
ccagacagat agtcaccagc attctgaagg aaggtgggca caggcctctg ctcgtattta   478980
cctggatccg cagatggatt cacgctttca agaggcttat ttagaagcaa tccagaactg   479040
gaatcaaact ggtgctttta actttgaact cgtgactgag tctagtaagg cggatattac   479100
ggctacggag atgaacgacg gaggcactcc tgtggcagga gaggcggaaa gtcaaactaa   479160
tctcttaaca gggcaattct tgtccgtaac ggtgcggttg aatcattatt atttgtccaa   479220
tccatactat ggctactcct atgaacgcct tgtccatacg gcagaacatg agttaggtca   479280
tgcgattggc ttggaccata cagatgagaa gtctgtcatg caaccagcag gttcctttta   479340
tggtatccag gaagaggatg ttgcaaacct ccgaaaaata tatgagacta gtgagtaggg   479400
tactatcttt ccctactttt tttgctataa tggaactatg aacaacttga ttaaatcaaa   479460
actagagctc ttgccgacca gccctggttg ctacattcat aaggataaaa atggcaccat   479520
tatctatgta ggaaaggcta aaaatctgcg taatcgagta cggtcctatt ttcgtggaag   479580
tcatgatacc aagacagagg ctctggtgtc tgaaattgtg gattttgaat ttattgttac   479640
ggagtctaat attgaggcac ttctcctaga aatcaacctg atcaaggaaa acaagcccaa   479700
gtacaatatc atgctcaagg atgacaagtc ctatcctttc atcaaaatca ccaatgagcg   479760
ctatccacgc ttgattatca ctcgtcaggt caaaaaggac ggaggtcttt attttggacc   479820
ctatcccgat gtgggggcag ccaatgaaat caagcggttg ctggatcgga tattcccttt   479880
tcgtaagtgt accaacccgc cctctaaggt ctgtttttat taccatatcg gccagtgtat   479940
ggcccacacc atctgtaaga aggatgaggc ttatttcaag tctatggccc aggaggtgtc   480000
tgattttctg aaaggtcagg atgacaaaat catcgatgat ctcaagagta aaatggcagt   480060
agcagcacaa agtatggagt ttgaacgtgc ggcggaatac cgtgacctga ttcaggctat   480120
tggaacgctt cgaaccaagc aacgggtcat ggcgaaagat ttgcaaaatc gcgatgtctt   480180
tggctactat gtggataagg gctggatgtg tgtgcaggtt ttctttgtcc gtcagggtaa   480240
gctcatcgag cgcgatgtca atctcttccc ctacttcaat gatccagatg aggatttttt   480300
gacctatgta ggacaattct atcaagaaaa atctcatcta gttcccaatg aggtactgat   480360
tccgcaggat attgacgaag aagctgtcaa ggctttggtg gattccaaga ttcttaagcc   480420
tcaacgtgga gagaaaaaac aactggtcaa tctagccata aaaaatgctc gtgttagtct   480480
agagcagaag ttcaatctgc tagaaaaatc tgtcgaaaag actcaaggag ctattgaaaa   480540
tctagggcgt ttgctccaaa tcccgacccc agtacgtatc gagtccttcg ataactctaa   480600
tatcatggga actagccctg tttcggctat ggtggtcttt gtcaacggta aaccgagtaa   480660
gaaggattac cgtaagtaca agataaaaac ggttgttgga ccagacgact atgccagcat   480720
gagagaggtc attcgcagac gctatggtcg agtacagcgt gaggctttga ctcctccaga   480780
tttgattgtg attgatgggg ggcaaggtca agtcaatatc gctaagcagg ttatccaaga   480840
ggaactgggc ttggatattc caattgctgg gctgcaaaag aatgataagc accaaaccca   480900
tgaattgctc tttggagatc cgcttgaggt ggtggatttg tctcgcaatt ctcaggaatt   480960
tttcctcctc caacgcatcc aagatgaggt gcaccgcttt gctatcactt tccaccgcca   481020
actgcgctcc aaaaattctt tctcatctca attggatggg attgacggtc tgggacctaa   481080
acgcaagcag aatcttatga agcatttcaa gtctttgacc aaaatcaagg aagccagtgt   481140
ggatgagatt gtcgaagttg gggtacctag agtcgttgca gaggctgtgc aaagaaagtt   481200
gaacccgcag ggagaagcct tgcctcaagt agcagaagaa agagtagatt accaaacgga   481260
aggaaaccac aatgaaccat aaaatcgcaa ttttatcaga tgttcatggc aatgcgacgg   481320
cgctagaagc agtgattgca gatgctaaaa atcaaggggc cagtgaatat tggcttctgg   481380
gagatatttt tcttcctggt ccaggcgcaa atgacttagt cgccctgcta aaggaccttc   481440
ctatcacagc aagtgttcga ggcaattggg atgatcgtgt ccttgaggct ttagatgggc   481500
aatatggctt agaagaccca caggaagttc agctcttgcg tatgacacag tatttgatgg   481560
agcgaatgga tcctgcaacg attgtctggc tacgaagctt gcctttgctg gaaaagaaag   481620
aaattgacgg attgcgcttt tctatctctc ataatttacc tgacaaaaac tatggtggtg   481680
acttgctagt tgagaatgat acagagaaat ttgaccaact gctagatgcg gaaacggacg   481740
tggcagttta tggtcatgtt cacaagcagt tgcttcgtta tggaagtcaa gggcaacaaa   481800
tcatcaatcc agggtcgatt ggcatgccct attttaattg ggaggcgtta aaaaatcacc   481860
gttcccagta tgccgtgata gaagttgaag atggggaatt actcaatatc caatttcgta   481920
aagttgctta tgattacgaa gctgagttag aattggccaa gtccaagggg cttcccttta   481980
tcgaaatgta tgaagaactg cgtcgtgacg ataactatca ggggcacaat ctggaattat   482040
tagccagctt aatagaaaag catgggtatg tagaggatgt gaagaatttt tttgattttt   482100
tgtaagagtt tcctaaaata gccaatgcaa actaaaaaag cgatttgctg gtccaatcgc   482160
ttttagtata tcttatactc aatgaaaatc aaagagcaaa ctaggaagct agccgtaggt   482220
tgctcaaagc acagctttga ggttgcagat aaagctgacg tggtttgaag agattttcga   482280
agagtgttat tgtaactgag attgatctgg gaggtaagaa ccacctagat aggtattgct   482340
gagtttttca agggttccgt cttgatagag ttctttgagc gctttatcaa attgctcttt   482400
aaactctttt tggtcgcttg agaaaatgat ataattgctg gggctatctg cagaaggtaa   482460
atcaacgact gagaggtcta aaccacggtc cttgataatc ttttgaacgg ataccttgtc   482520
aaaaactagg aaatcaaact ctccgttagc aaggtctagg attcgtttac caatatcctc   482580
accagaaaaa ttaattgtag cgggattatc agtgtgtttc tgattccagt tattgatgaa   482640
ttgagcgtta gaagttccgg tatcctcttg tgttgtttta ccagcgatct ggtcaagaga   482700
agtcaaagga tttttcttgt tgctgacaag gacgagggga ttgttggaaa ttggaagcga   482760
gtaaaggtat ttttcagcac gctcttttgt gtaactcaag ttattggccg cagcctgata   482820
gtgaccagaa tcaagtcctg ggaagatgct ctcccaggcg gttctttgga attgaatctc   482880
gtagtcgctg agtttttcat ctactgcctt taaaacttcg atatcaaagc ctgtcagatt   482940
gcccttgtct tcgtagtcaa atggtggcac gtcgccagct gtagcaagga cgattgtctt   483000
ttgagcgcta gtctctttgg gtgtagcttg attctcacag gcaaccaaaa atggtaggat   483060
agctagtaat aggctaaatt ttttcatact gtctccattc aaatgtaaag tacttgctag   483120
tttatcagaa actttcctga taaaccaata tatatctttt atgtctgtga tagaaaaact   483180
taatcatgaa aaatccctgc aagctctttc aaattatggt agaatggaag cagtagaatt   483240
agaaaaggaa atcgattatg aaatttcttg aattaaataa aaaacgtcat gcgactaagc   483300
attttactga taagcttgtt gatcccaaag atgtgcgtac ggctatcgaa attgcaacct   483360
tggcgccaag cgcccacaac agccagcctt ggaaatttgt ggtggtacgt gagaaaaatg   483420
ctgaactggc aaagttagct tatggttcca attttgaaca ggtatcatca gcgcctgtaa   483480
ccattgcctt gtttacagat acggacttag ccaaacgtgc tcgtaagatt gcccgtgttg   483540
gtggtgctaa taacttttct gaagagcaac ttcaatattt tatgaaaaat ctgccagctg   483600
agtttgcccg ttacagtgag caacaagtca gcgactacct agctctcaat gcaggtttgg   483660
ttgccatgaa cttggttctt gcattgacag accaaggaat tggttctaac attattcttg   483720
gttttgacaa atcaaaagtt aatgaagttt tggaaatcga agaccgtttc cgcccagaac   483780
tcttgatcac agtgggttat acagacgaaa aattggaacc aagctaccgc ttgccagtag   483840
atgaaatcat cgagaaaaga tagaaagaag aaaaaatgac agcaattgat tttacagcag   483900
aagtagaaaa acgcaaagaa gacctcttgg ctgacttgtt tagccttttg gaaatcaatt   483960
cagaacgtga tgacagcaag gctgatgccc agcatccatt tgggcctggt ccagtaaaag   484020
ccttggagaa attccttgaa atcgcagacc gcgatggcta cccaactaag aatgttgata   484080
actatgcagg acattttgag tttggtgatg gagaagaagt tctcggaatc tttgcccata   484140
tggatgtggt gcctgctggt agcggttggg acacagaccc ttacacacca actatcaaag   484200
atggtcgcct ttatgcgcgc ggggcttcgg acgataaggg tcctacaaca gcttgttact   484260
atggtttgaa aatcatcaaa gaattgggtc ttccaacttc taagaaagtt cgcttcatcg   484320
ttggaacaga cgaagaatca ggctgggcag acatggacta ctactttgag cacgtaggac   484380
ttgccaaacc agatttcggt ttctcaccag atgctgaatt tccaatcatc aatggtgaaa   484440
aaggaaatat cacggaatac ctccactttg caggagaaaa tacaggtgtt gcccgtcttc   484500
acagctttac aggtggttta cgtgaaaata tggtaccaga atcagcaaca gcagtcgttt   484560
caggtgactt ggctgacttg caagctaaac tagatgcctt tgttgcagaa cacaaactta   484620
gaggagaact ccaagaagaa gctggcaaat acaaggtgac gatcattggt aaatcagccc   484680
acggtgctat gcctgcttca ggtgtcaatg gcgcaactta ccttgccctc ttcctcagcc   484740
agtttggctt tgctggtcca gccaaagact accttgacat cgcaggtaaa attctcttga   484800
acgatcatga gggtgaaaat cttaagattg ctcatgtgga tgaaaagatg ggtgctcttt   484860
ctatgaatgc cggcgtcttc cacttcgatg aaacaagtgc tgataatacc attgccctca   484920
acatccgcta tccaaaagga acaagtccag aacaaatcaa gtcaatcctt gaaaacttgc   484980
cagttgtttc tgttagcctg tctgaacacg gtcacacgcc tcactatgtg ccaatggaag   485040
atccacttgt gcaaaccttg ttgaatatct atgaaaaaca aactggcttt aaaggtcatg   485100
aacaagtcat cggtggtgga acctttggtc gcttgctaga acgcggagtt gcctacggtg   485160
ctatgttccc agactcgatt gataccatgc accaagccaa tgaatttatc gccttggatg   485220
atcttttccg agcagcagca atttatgccg aagctattta cgaattgatc aaataaaacg   485280
atagaagtct gagatcttat gcttggactt ctttttggag ggaaagtaga tgtctcaaat   485340
cgaaagaatc aaacaggcta tcatggcgga ttcgcagaat gccagctata cagagcgtgg   485400
cattgagcct ctctttgcag cgccaaaaac tgctcgcatc aatatcatcg gtcaggctcc   485460
gggacttaaa actcaagaag caggccttta ctggaaagat aaaagtggtg accgcttgcg   485520
ggactggcta ggtgtggatg aagatacctt ttacaattca ggttattttg ctgttttgcc   485580
tatggatttc tactttccag gacatggcaa gtcgggtgat cttccgcctc gtacaggttt   485640
tgcagaaaaa tggcatccgc aggtcttaca ggaattgcct gatattcagt taaccctctt   485700
gattgggcaa tatgcccaag cctactattt acaggagaaa atcagtggga aggtaacgga   485760
gagggtgaaa cactataaag actatctgcc agcctatttt ccgctagttc acccatcacc   485820
acgaaatcaa atctggatgg ccaaaaatcc ttggtttgag gcagaagtag tgccagattt   485880
gaaaaaaaga attaaaacca ttttatagtc aatgaaaatc aaagagcaaa ctaggaagct   485940
agtcgtaggc tgctcaaagt acagctttga agttgcagat aaaactgacg aagtcggtaa   486000
catacgcacg gtaaggcgac gctgacgtgg tttgaagaga ttttcgaaga gtattagaag   486060
aaaaagaatg aaagaaatag cctttgacgc attttaccag ctttaccaaa acgaccagct   486120
ttctttagtg gatgtgagag aagtggatga gtttgcagct cttcatttag aaggtgccca   486180
caacctaccg cttagtcaat tggctgatag ttatgattaa ttggacaaag atcgcttgca   486240
ttatattatt tgcaaatctg gaatgagatc ggcgcgtgct tgccaattcc tattagaaca   486300
aggttataat gttatcaatg tccagggtgg catgttagcc tttgaagaac tttaaaattt   486360
tgcatttctc ctacttggtg tggactgggt aggagagttt tatttttaga taattcttat   486420
ttttaagaaa attgaaaaca tttaatattt gcctcgtgat gcttttttca gactcctaat   486480
cgtggtatac taggtcagta ttttataaat atgaaggaga tttttatggc taaaaaaggt   486540
accctaacag gtttgctcct gtttggaata ttttttggtg cggggaactt gatttttccg   486600
ccttctctag gtgctctatc tggagaacat tttcttcctg ccatcgcagg ttttgtcttt   486660
tcaggcgttg gtatcgccgt cttgaccctt attattggaa cgctaaatcc taaaggatat   486720
atctacgaga tttcaacgaa gatagcgcct tggtttgcga ctctttacct ctcagttctt   486780
tacttgtcaa tcggtccatt ctttgctacc ccacgtactg ctacaacagc ttacgaagta   486840
gggattagcc cccttttgtc ggatgcaaat aaaggacttg gcttgattgt atttacggtt   486900
ctgtattttg cggcagccta tttgatttcg cttaatccat caaaaatctt agaccgcatt   486960
ggacgtattt taacgccagt ctttgcaatt ttgattgtta tcttggtcgt tctgggagct   487020
atcaaatatg gtggaacaag tcctcaagct gcttcactgc ttatcaagct tctgcctttg   487080
gtacaggttt cctagaaggt tacaatacct tggacgccct tgcctcagtg gcctttagcg   487140
taatcgcagt tcaaaccttg aaacaacttg gattttcaag taagaaagaa tacatttcaa   487200
ctatttgggt tgttggtatc gttgttgccc ttgccttcag cgctctttac atcggtttag   487260
gttttcttgg aaatcatttc ccagtaccag ctgaagcgat gaagggtgga acaccaggtg   487320
tttacatctt gtcacaagcc actcaagaaa tctttggctc aacagctcaa ctcttccttg   487380
cagctatggt taccgtaacc tgcttcacaa cgactgttgg tttgattgtg tcaacagctg   487440
agttctttaa tgagcgcttc ccacaaatca gctacaaggt ttatgcgaca gcctttacct   487500
tgattggatt tgctattgcc aatttgggtc ttgatgcgat tatcaagtac tcaattccag   487560
tactggttat cttgtaccca atcacgattg ctatcgttat gattgtcatt gtcaacaaat   487620
ttgttgccct ttcaaaacca ggtatgcagt tgacaattgc tgtggttaca gttattgcca   487680
ttgcaagcgt actaggaagc tcgttaaggt tgagtttctt gcaaatcttg ttagcgttct   487740
tccttttgcc aaggcatctc tcccatggtt ggtgccagcc attgttggaa tcttgctctc   487800
attggttcta ccaaacaagc aagaaagcga tgtttttgaa atggaataat cacttaaatc   487860
acttttgtag ccaagtctac aggagtgatt ttcttttttt atccgatgat aaatgtgtta   487920
taataggtag cgaaagaggt gaagaaatga atcaaacagt agaatatatc aaagaactga   487980
cagccattgc gtcgccaaca ggctttactc gtgagattgc ggactattta gtcaagactc   488040
tagaaggttt tggttaccag ccggttcgca catccaaggg cggtgtcaat gtaactatta   488100
aaggtcaaaa tgatgagcaa catcgctatg tgactgccca tgtagatacg cttggtgcta   488160
ttgtccgtgc tgtcaaacca gacggccgtc tcaaaatgga ccgtatcggt ggctttcctt   488220
ggaacatgat tgaaggagaa aactgtacca ttcatgtggc tagcacaggt gaaaaagtat   488280
caggaaccat cctcatccac caaacttctt gccatgtcta taaggatgca ggaactgcag   488340
aacgcacgca agacaatatg gaagtgcgtt tggacgccaa agtaactagt gaaaaagaaa   488400
ctcgtgctct tggcattgag gtcggtgatt ttatcagttt tgacccacga actgtcgtga   488460
cagagacagg ttttatcaag tctcgccatt tggatgacaa ggtcagtgcg gcgattttgc   488520
tcaatctcct tcgcatttat aaggaagaga agattgaatt gcccgtaaca actcattttg   488580
ctttttcagt ctttgaagaa gtgggacacg gtgcaaactc taacattcct gctcaggtag   488640
tagaatatct ggctgtggat atgggagcca tgggagatga ccagcaaaca gacgaatata   488700
cagtgtctat ctgtgtcaag gatgcttctg gaccttatca ctatgacttc cgtcaacatt   488760
tggtggcttt ggcgaaagag caagatattc catttaagct ggatatctat ccattttatg   488820
gttcggacgc ttcagcggct atgtctgcag gggcagaagt caaacacgcc cttctcggtg   488880
ctggtataga gtctagccat tcctatgagc gtacccatat tgactcggtg atcgcaacag   488940
aacgaatggt cgatgcttat cttaagagca cgttggtgga ctaatatgtg ccttatttgt   489000
cagagaattg acctcatcaa gaaggaagaa aatccttact ttgtcaaaga gttggaaaca   489060
ggctatcttg tggttggaga ccaccagtat tttgaaggct atagtctctt tctagccaag   489120
gagcatgtca gcgaattgca ccatttgaaa aaggagacaa gactccgttt tctagaagaa   489180
atgagtttag tccaagaggc agttgccaag gcctttgctg ctgagaaaat gaatatcgaa   489240
ctgctaggaa atggcgatgc tcatcttcat tggcatctgt ttccacgacg gacaggtgat   489300
atgaatggtc atggtctcaa gggtcgtgga ccagtctggt gggttccctt tgaagaaatg   489360
acagcagaaa cctgccaagc aaaaccggat gagattaaaa gattagtcaa acgtttatcg   489420
tcagaagtag ataaactatt agaaataaag gagtagaaat gaagaaaaga tacctagtct   489480
tgacagcttt gctagccttg agtctagcag cttgttcaca agaaaaaaca aaaaatgaag   489540
atggagaaac taagacagaa cagacagcca aagctgatgg aacagtcggt agtaagtctc   489600
aaggagctgc ccagaagaaa gcagaagtgg tcaataaagg tgattactac agcattcaag   489660
ggaaatacga tgaaatcatc gtagccaaca aacactatcc attgtctaaa gactataatc   489720
caggggaaaa tccaacagcc aaggcagagt tggtcaaact catcaaagcg atgcaagagg   489780
caggtttccc tattagtgat cattacagtg gttttagaag ttatgaaact cagaccaagc   489840
tctatcaaga ttatgtcaac caagatggaa aggcagcagc tgaccgttac tctgcccgtc   489900
ctggctatag cgaacaccag acaggcttgg cctttgatgt gattgggact gatggtgatt   489960
tggtgacaga agaaaaagca gcccaatggc tcttggatca tgcagctgat tatggctttg   490020
ttgtccgtta tctcaaaggc aaggaaaagg aaacaggcta tatggctgaa gaatggcacc   490080
tgcgttatgt aggaaaagaa gctaaagaaa ttgctgcaag tggtctcagt ttggaagaat   490140
actatggctt tgaaggcgga gactacgtcg attaatactc ttcgaaaatc tcttcaaacc   490200
acgtcagcgt cgccttacct actgactgcg tcggttctat tcacaacctc aaaacagtgt   490260
tttgagctga cttcgtcagt tttatctgca acctcaaagc tgtactttga gcagcctgcg   490320
gctagcttcc tagtttgctc tttgattttc attgagtaca aaaagtaaac ttttctcttg   490380
caattccaga taaatagtgt ataatggatg ggtatgtgaa aaacatactt gtgggaggta   490440
aaaatctcta attaccgcca aaaccacaaa ggaggattta aaaatggcta aaaaagtcga   490500
aaaacttgta aaattgcaaa tccctgctgg taaagctaca ccagctccac cggttggacc   490560
tgctcttggt caagctggta tcaacatcat gggattcaca aaagagttca acgctcgtac   490620
agctgaccaa gctggtatga tcattccagt tgttatctca gtttacgaag ataaatcatt   490680
tactttcgtt acgaaaacac caccagctgc tgttcttttg aaaaaagctg caggtgttga   490740
aaaaggatca ggtacaccta ataaaactaa agttgctaca gttactcgtg cacaagtaca   490800
agaaattgca gaaactaaga tgccagattt gaacgcagca aacgtagagt ctgcaatgcg   490860
tatgatcgaa ggtactgctc gttctatggg attcactgtt gttgactaat caataacaca   490920
gtagaaaatc tcacagcagt ctattagttg cttttcatac taggcaagtg actgaggctt   490980
gtacttgggt acagcaaggg agcttaaggc cgtagaagag aaaaatagta gactgaaaac   491040
ccgcaagact tcatcatttc gagaagtgac gtgggagatg aaaatcgatt gaaccactta   491100
caaggagaat agaaaatggc taaaaaaagc aaacaacttc gtgctgctct tgagaaaatc   491160
gacagcacaa aagcatacag tgtagaagaa gctgtagcac ttgcaaaaga aactaacttt   491220
gcaaaatttg atgcaactgt agaagttgct tacaacttga acatcgacgt taaaaaagct   491280
gaccaacaaa tccgtggagc aatggtattg ccaaacggta ctggtaaaac ttcacgtgtt   491340
cttgttttcg cacgtggtgc aaaagctgaa gaagcaaaag ctgctggtgc agactttgtt   491400
ggtgaagatg accttgttgc taaaatcaac gacggttggt tggacttcga cgtagttatc   491460
gctacacctg atatgatggc tcttgttgga cgtcttggac gtgtccttgg accacgtaac   491520
ttgatgccaa accctaaaac tggtactgta acaatggatg ttgctaaagc agttgaagag   491580
tctaaaggtg gtaaaatcac ttaccgtgct gaccgtgcag gtaacgttca agcaatcatc   491640
ggtaaagtat catttgaagc tgaaaaattg gttgaaaact ttaaagcttt caacgaaaca   491700
atccaaaaag caaaaccagc tacagctaaa ggaacttacg taacaaactt gactatcaca   491760
actactcaag gtgttggtat caaagttgac gtaaactcac tttaatcagt agttaaagta   491820
atgtaaaaaa gttgaagacg ctatgtctca actttttttg atgtacgacg ggcatgttgt   491880
atagtagatg tgtactattc tagtttcaat ctactatagt agctcagaag tcggtactta   491940
aacgtgctat atcaaaacca gtccttgaaa aacgtggact ggtttcgtgt ttggattatt   492000
accttgaacg acatgcgtta aaagttagtt gaaccgccgt atgccgaacg gcacgtacgg   492060
tggtgtgaga ggggctagag attatcccct actcgatttc gaaatctagt ggaatgaatc   492120
tggaatagtc catcgagctt tctaatactc ttcgaaaatc tcttcaaacc acgtcaacgt   492180
cgccttgccg tgcgtatggt tactgacttc gtcagttcta tccacaacct caaaacagtg   492240
ttttgagctg actacgtcag ttccatctac aacctcaaaa cagtgttttg agcaacctgc   492300
ggctagtttc ctagtttgct ctttggtttt cattgagtat aacacattgt tagaagttgg   492360
tttaaatttc ctaatcagtt tgttcacatt taccttcgat atattatatc ccatagttaa   492420
ggttggtcat acagatgatt atagtcatgg agccgtaaaa cttagtgttt ctttagttga   492480
caaagatgcc atgaaaaaaa tatttgtaac tgtaatagga tattttgaaa taaatataga   492540
tgaaaatatc accgatattc tatacgtaaa tggtactgct attctttatc tttatttacg   492600
ttcaattgtt tcaatagttt cggcaattga tagcagtgaa gcaatgttgc tacctatcat   492660
taatgtttta gagttactag ataaatctca accttttgaa gaagaataat ttattagctc   492720
actaaattga gggtaaggaa aagtaaaagc agtaagaaaa atgtcttgca ttatacagca   492780
accttttggg aatgagtgga tggattgaat aaaatttgat taagagtgga tgatttatct   492840
gtagattatt attggacagt tagtcttgaa gtagtctaag aattaggtta taatcagtag   492900
aagccttgct aataatgagg aggttagttt atgtatagta gactgaatct aaaatagtac   492960
gaaacaattg ctaaaacatt tatagaaatt aattttactt tcccaatcga tttgttctca   493020
tcttatttca atccgctata tattatggta tcgaatcttc atcagaatga taaaattaat   493080
caattgatat ctgattacaa acagaatatg aaagcttttt atatcactat tgaaaaattt   493140
atacgagatg atgaaagcct taagtgttat tttataaagg ttatttcaag tcgttccaag   493200
gtaacaagtc tagatcagat tgaagctgat aaaacgatac aaagaaaata ttcaagtgag   493260
ctaaaaaaat ttattggatt ttataatgag attatttgtg aggaaaatag tttcctacat   493320
gtacgaaaga ggtggtcgag ttggtttagg tagtcgatgc gtgagttgat aattctcagg   493380
gtatggactt ctttttcatg aatgaggtaa aagagcaggt attgtttaga gacaatcatt   493440
ctgagcatat tttctggata gagggagtat ccgattttat gatcaaagtt aataccgccc   493500
tctggtgaga agatgagtag gttggtaatt taaactatta aacagaattt ttgattaaaa   493560
gtattatttc atgagagaaa tcctaatttc acaatccata ggcaaacgct tgcatttcgt   493620
tttttattgg actataatag gttggtataa agccttctgt agtaataaaa tgtagaaggt   493680
gtagaaagta aggatttaga atatttgtag ttaaaaacac aatgttgcta ttccttacga   493740
tagggagata gatatggcaa tgatagaagt ggaacatctt cagaaaaatt ttgtgaagac   493800
tgttaaggaa ccgggcttga agggggcttt gcgctccttt attcatcctg aaaagcagac   493860
ctttgaagcg gtcaaggatt tgacctttga ggttccaaaa gggcagattt taggatttat   493920
cggggcaaat ggtgctggga agtcgacaac cattaaaatg ctgacaggaa ttttgaaacc   493980
aacatctggt ttttgtcgga ttaacggcaa gattccccag gacaatcggc aagattatgt   494040
caaagatatt ggcgtagtct ttggacaacg cacccagcta tggtgggatt tggctctgca   494100
agagacctac actgtcttaa aagagattta tgatgtgcca gactcgctct ttcataagcg   494160
tatggacttt ttgaatgaag tcttggattt gaaggacttt atcaaggatc ccgtgcggac   494220
tctttcactg ggacaacgga tgcgggcgga tattgcggcc tccttgctcc acaatcccaa   494280
ggttcttttt ttagatgagc cgaccattgg tttggacgtt tcggttaagg ataatattcg   494340
tcgggcaatt actcagatca atcaagagga agaaactacc attcttttga ccactcacga   494400
tttgagtgat attgagcaac tttgtgatcg gattttcatg attgacaagg ggcaagagat   494460
ttttgatgga acggtgagcc aactcaagga gacctttggt aagatgaaga ctctctcttt   494520
tgaactgcta ccaggtcaaa gtcatctcgt ctctcactat gacggtctgt ctgatatgac   494580
cattgataga caaggaaaca gcctcaacat tgaatttgat agttctcgct accagtcagc   494640
tgacattatc aagcaaaccc tgtctgattt tgaaatccgc gatttgaaga tggtggatac   494700
ggatattgag gatattatcc gtcgcttcta ccgaaaggag ctctaggatg atcaaattgt   494760
ggagacgtta taaacccttt atcaatgcag gggttcagga gttgattact taccgagtca   494820
actttattct ctatcggatt ggcgatgtca tgggggcttt tgtggccttt tatctctgga   494880
aggctgtctt tgattcttcg caagagtctt tgattcaggg cttcagtatg gcggatatca   494940
ccctctacat catcatgagt tttgtgacca atcttctgac tagatccgat tcgtccttta   495000
tgattgggga ggaggtcaag gatggctcca ttatcatgcg tttgttgcga ccagtgcatt   495060
ttgcggcctc ctatcttttc accgagcttg gttccaagtg gttgattttt atcagcgttg   495120
gccttccatt tttaagtgtc attgtcttga tgaaaatcat atcgggtcaa ggtattgtag   495180
aggtgctagg attaactgtc atttatcttt ttagcttaac gctcgcctat ctgattaact   495240
ttttctttaa tatttgcttt ggattttcag cctttgtgtt taaaaatctt tggggttcca   495300
acctacttaa gacttccata gtggctttta tgtcggggag tttgattccc ttggcatttt   495360
ttccaaaggt tgtttcagat attctctcct ttttgccttt ttcatccttg atttatactc   495420
cagttatgat cattgttgga aaatacgatg ccagtcagat tcttcaggca ctccttttgc   495480
agttcttctg gctcttagtg atggtgggat tgtctcagtt aatttggaaa cgggtccagt   495540
cctttatcac cattcaagga ggttagtatg aaaaaatatc aacgaatgca tctgattttt   495600
atcagacaat acatcaaaca aatcatggaa tataaggtag attttgtggt tggtgtcttg   495660
ggagtctttc tgactcaagg cttgaatctc ttgtttctca atgtcatctt tcaacatatt   495720
ccattcctag aaggctggac ctttcaagag atagctttca tttatggatt ttccttgatt   495780
cccaagggaa tggaccatct cttttttgac aatctctggg cactagggca acgcctagtc   495840
cgaaaagggg agtttgacaa gtatctgact cgtcccatca atcctctctt tcacatccta   495900
gttgaaacct ttcagattga tgccttgggt gaactcttag tcggtggtat tttattggga   495960
acaacagtga ccagcattgt ttggactctt ccaaaattcc tgcttttcct agtttgtatt   496020
ccttttgcga ccttgattta tacttctctt aaaatcgcaa cagccagtat cgccttttgg   496080
actaagcagt caggcgccat gatttacatc ttctatatgt tcaatgactt tgctaagtat   496140
ccgatttcta tttacaattc tcttcttcgt tggttgatta gctttatcgt gcctttcgcc   496200
tttacagcct actatccagc tagctatttc ttacaggaaa aggatgtgtt ctttaacgta   496260
ggaggtttga tgttgatttc tctggttttc tttgttattt cccttaaact ttgggataag   496320
ggcttagatt cctacgaaag tgcgggttcg taaaagctaa agtaagacta aaatcaagaa   496380
agaaacttat gatgtttgta attgaagaag tcaaggatga aaatcaaaaa aaggcagttg   496440
tcgctgaggt tttgaaggat ttgccagaat ggtttggaat cccagaaagc acacaagcct   496500
atatagaagg aaccacgaca ctgcaagttt ggaccgccta tcaggagagt gatttgacta   496560
gatttgtaag cttatcctat tcgagtgaag attgtgcaga gattgattgt ctcggcgtaa   496620
aaaagcttat caaggtagaa aaattgggag ccaattgctt gctactttag agagtgaagc   496680
tcgtaaaaaa gttggttatc tgcaggtcaa aacagtggca gaaggttcta ataaagatta   496740
tgatcgaaca aatgactttt atcgaggtct tggctttaaa aagttagaga tttttcctca   496800
actatggaat ccgcaaaatc cttgtcagat tttgattaaa aagcttgaat aatattactt   496860
gacatctatt ctcagagtgc tatactgtaa gtgtaatcgc cgatttagct tagttggtag   496920
agcaaggcac tcgtaaagcc taggttatag gtagataaac gactgaggat ttgaaaaaat   496980
agataggtag aagataaccg ttaagcctta ctcttagcgg ttatttatat tgtttaatag   497040
cgctaatatt ttatcaatta tgcctgtttt cgtgtttctg gtagttgttc aagtttattg   497100
ctactatttt tgatggtatg aatgtgctta taatgtatcc cggttaacga aagttttgga   497160
cttatactct tcgaaaatct cttcaaacca cgtcaacgtc gccttgccgt gcgtatggtt   497220
actgacttcg tcagttctat ccacaacctc aaaacagtgt tttgagctga ctacgtcagt   497280
tccatctaca acctcaaaac actgttttga gcaatctgcg gctagtttcc tagtttgctc   497340
tttgattttc attgagtact aatcttattt tttaatgtgt gctaaaaaat aaattaacta   497400
atgttaattt ttttgactta aattttttta aatgatatac tgtttttata gagagataac   497460
aattatatat aaatgtacta ctctatttcc tagataatac ttagtaaaac tttttataac   497520
aaaggctagc aaagttaaag tttattatct attggaagtt atataaatat gtaaggaatt   497580
aaaatgaaaa aaagtacagt attgtcatta accacagctg cagttatttt agcagcctat   497640
gcccctaatg aggtagtctt agcagacaca tctagctctg aagatgcttt aaacatctct   497700
gataaagaaa aagtagcaga aaataaagag aaacatgaaa atatccatag tgctatggaa   497760
acttcacagg attttaaaga gaagaaaaca gcagtcatta aggaaaaaga agttgttagt   497820
aaaaatcctg tgatagacaa taacactagc aatgaagaag caaaaatcaa agaagaaaat   497880
tccaataaat cccaaggaga ttatacggac tcatttgtga ataaaaacac agaaaatccc   497940
aaaaaagaag ataaagttgt ctatattgct gaatttaaag ataaagaatc tggagaaaaa   498000
gcaatcaagg aactatccag tcttaagaat acaaaagttt tatatactta tgatagaatt   498060
tttaacggta gtgccataga aacaactcca gataacttgg acaaaattaa acaaatagaa   498120
ggtatttcat cggttgaaag ggcacaaaaa gtccaaccca tgatgaatca tgccagaaag   498180
gaaattggag ttgaggaagc tattgattac ctaaagtcta tcaatgctcc gtttgggaaa   498240
aattttgatg gtagaggtat ggtcatttca aatatcgata ctggaacaga ttatagacat   498300
aaggctatga gaatcgatga tgatgccaaa gcctcaatga gatttaaaaa agaagactta   498360
aaaggcactg ataaaaatta ttggttgagt gataaaatcc ctcatgcgtt caattattat   498420
aatggtggca aaatcactgt agaaaaatat gatgatggaa gggattattt tgacccacat   498480
gggatgcata ttgcagggat tcttgctgga aatgatactg aacaagacat caaaaacttt   498540
aacggcatag atggaattgc acctaatgca caaattttct cttacaaaat gtattctgac   498600
gcaggatctg ggtttgcggg tgatgaaaca atgtttcatg ctattgaaga ttctatcaaa   498660
cacaacgttg atgttgtttc ggtatcatct ggttttacag gaacaggtct tgtaggtgag   498720
aaatattggc aagctattcg ggcattaaga aaagcaggca ttccaatggt tgtcgctacg   498780
ggtaactatg cgacttctgc ttcaagttct tcatgggatt tagtagcaaa taatcatctg   498840
aaaatgaccg acactggaaa tgtaacacga actgcagcac atgaagatgc gatagcggtc   498900
gcttctgcta aaaatcaaac agttgagttt gataaagtta acataggtgg agaaagtttt   498960
aaatacagaa atataggggc ctttttcgat aagagtaaaa tcacaacaaa tgaagatgga   499020
acaaaagctc ctagtaaatt aaaatttgta tatataggca aggggcaaga ccaagatttg   499080
ataggtttgg atcttagggg caaaattgca gtaatggata gaatttatac aaaggattta   499140
aaaaatgctt ttaaaaaagc tatggataag ggtgcacgcg ccattatggt tgtaaatact   499200
gtaaattact acaatagaga taattggaca gagcttccag ctatgggata tgaagcggat   499260
gaaggtacta aaagtcaagt gttttcaatt tcaggagatg atggtgtaaa gctatggaac   499320
atgattaatc ctgataaaaa aactgaagtc aaaagaaata ataaagaaga ttttaaagat   499380
aaattggagc aatactatcc aattgatatg gaaagtttta attccaacaa accgaatgta   499440
ggtgacgaaa aagagattga ctttaagttt gcacctgaca cagacaaaga actctataaa   499500
gaagatatca tcgttccagc aggatctaca tcttgggggc caagaataga tttactttta   499560
aaacccgatg tttcagcacc tggtaaaaat attaaatcca cgcttaatgt tattaatggc   499620
aaatcaactt atggctatat gtcaggaact agtatggcga ctccaatcgt ggcagcttct   499680
actgttttga ttagaccgaa attaaaggaa atgcttgaaa gacctgtatt gaaaaatctt   499740
aagggagatg acaaaataga tcttacaagt cttacaaaaa ttgccctaca aaatactgcg   499800
cgacctatga tggatgcaac ttcttggaaa gaaaaaagtc aatactttgc atcacctaga   499860
caacagggag caggcctaat taatgtggcc aatgctttga gaaatgaagt tgtagcaact   499920
ttcaaaaaca ctgattctaa aggtttggta aactcatatg gttccatttc tcttaaagaa   499980
ataaaaggtg ataaaaaata ctttacaatc aagcttcaca atacatcaaa cagacctttg   500040
acttttaaag tttcagcatc agcgataact acagattctc taactgacag attaaaactt   500100
gatgaaacat ataaagatga aaaatctcca gatggtaagc aaattgttcc agaaattcac   500160
ccagaaaaag tcaaaggagc aaatatcaca tttgagcatg atactttcac tataggcgca   500220
aattctagct ttgatttgaa tgcggttata aatgttggag aggccaaaaa caaaaataaa   500280
tttgtagaat catttattca ttttgagtca gtggaagaaa tggaagctct aaactccaac   500340
gggaagaaaa taaacttcca accttctttg tcgatgcctc taatgggatt tgctgggaat   500400
tggaaccacg aaccaatcct tgataaatgg gcttgggaag aagggtcaag atcaaaaaca   500460
ctgggaggtt atgatgatga tggtaaaccg aaaattccag gaaccttaaa taagggaatt   500520
ggtggagaac atggtataga taaatttaat ccagcaggag ttatacaaaa tagaaaagat   500580
aaaaatacaa catccctgga tcaaaatcca gaattatttg ctttcaataa cgaagggatc   500640
aacgctccat catcaagtgg ttctaagatt gctaacattt atcctttaga ttcaaatgga   500700
aatcctcaag atgctcaact tgaaagagga ttaacacctt ctccacttgt attaagaagt   500760
gcagaagaag gattgatttc aatagtaaat acaaataaag agggagaaaa tcaaagagac   500820
ttaaaagtca tttcgagaga acactttatt agaggaattt taaattctaa aagcaatgat   500880
gcaaagggaa tcaaatcatc taaactaaaa gtttggggtg acttgaagtg ggatggactc   500940
atctataatc ctagaggtag agaagaaaat gcaccagaaa gtaaggataa tcaagatcct   501000
gctactaaga taagaggtca atttgaaccg attgcggaag gtcaatattt ctataaattt   501060
aaatatagat taactaaaga ttacccatgg caggtttcct atattcctgt aaaaattgat   501120
aacaccgccc ctaagattgt ttcggttgat ttttcaaatc ctgaaaaaat taagttgatt   501180
acaaaggata cttatcataa ggtaaaagat cagtataaga atgaaacgct atttgcgaga   501240
gatcaaaaag aacatcctga aaaatttgac gagattgcga acgaagtttg gtatgctggc   501300
gccgctcttg ttaatgaaga tggagaggtt gaaaaaaatc ttgaagtaac ttacgcaggt   501360
gagggtcaag gaagaaatag aaaacttgat aaagacggaa ataccattta tgaaattaaa   501420
ggtgcgggag atttaagggg aaaaatcatt gaagtcattg cattagatgg ttctagcaat   501480
ttcacaaaga ttcatagaat taaatttgct aatcaggctg atgaaaaggg gatgatttcc   501540
tattatctag tagatcctga tcaagattca tctaaatatc aaaagcttgg cgagattgca   501600
gaatctaaat ttaaaaattt aggaaatgga aaagagggta gtctaaaaaa agatacaact   501660
ggggtagaac atcatcatca agaaaatgaa gagtctatta aagaaaaatc tagttttact   501720
attgatagaa atatttcaac aattagagac tttgaaaata aagacttaaa gaaactcatt   501780
aaaaagaaat ttagagaagt tgatgatttt acaagtgaaa ctggtaagag aatggaggaa   501840
tacgattata aatacgatga taaaggaaat ataatagcct acgatgatgg gactgatcta   501900
gaatatgaaa ctgagaaact tgacgaaatc aaatcaaaaa tttatggtgt tctaagtccg   501960
tctaaagatg gacactttga aattcttgga aagataagta atgtttctaa aaatgccaag   502020
gtatattatg ggaataacta taaatctata gaaatcaaag cgaccaagta tgatttccac   502080
tcaaaaacga tgacatttga tctatacgct aatattaatg atattgtgga tggattagct   502140
tttgcaggag atatgagatt atttgttaaa gataatgatc agaaaaaagc tgaaattaaa   502200
attagaatgc ctgaaaaaat taaggaaact aaatcagaat atccctatgt atcaagttat   502260
gggaatgtca tagaattagg ggaaggagat ctttcaaaaa acaaaccaga caatttaact   502320
aaaatggaat ctggtaaaat ctattctgat tcagaaaaac aacaatatct gttaaaggat   502380
aatatcattc taagaaaagg ctatgcacta aaagtgacta cctataatcc tggaaaaacg   502440
gatatgttag aaggaaatgg agtctatagc aaggaagata tagcaaaaat acaaaaggcc   502500
aatcctaatc taagagccct ttcagaaaca acaatttatg ctgatagtag aaatgttgaa   502560
gatggaagaa gtacccaatc tgtattaatg tcggctttgg acggctttaa cattataagg   502620
tatcaagtgt ttacatttaa aatgaacgat aaaggggaag ctatcgataa agacggaaat   502680
cttgtgacag attcttctaa acttgtatta tttggtaagg atgataaaga atacactgga   502740
gaggataagt tcaatgtaga agctataaaa gaagatggct ccatgttatt tattgatacc   502800
aaaccagtaa acctttcaat ggataagaac tactttaatc catctaaatc taataaaatt   502860
tatgtacgaa atccagaatt ttatttaaga ggtaagattt ctgataaggg tggttttaac   502920
tgggaattga gagttaatga atcggttgta gataattatt taatctacgg agatttacac   502980
attgataaca ctagagattt taatattaag ctgaatgtta aagacggtga catcatggac   503040
tggggaatga aagactataa agcaaacgga tttccagata aggtaacaga tatggatgga   503100
aatgtttatc ttcaaactgg ctatagcgat ttgaatgcta aagcagttgg agtccactat   503160
cagtttttat atgataatgt taaacccgaa gtaaacattg atcctaaggg aaatactagt   503220
atcgaatatg ctgatggaaa atctgtagtc tttaacatca atgataaaag aaataatgga   503280
ttcgatggtg agattcaaga acaacatatt tatataaatg gaaaagaata tacatcattt   503340
aatgatatta aacaaataat agacaagaca ctaaacatta agattgttgt aaaagatttt   503400
gcaagaaata caaccgtaaa agaattcatt ttaaataaag atacgggaga ggtaagtgaa   503460
ttaaaacctc atagggtaac tgtgaccatt caaaatggaa aagaaatgag ttcaacgata   503520
gtgtcggaag aagattttat tttacctgtt tataagggtg aattagaaaa aggataccaa   503580
tttgatggtt gggaaatttc tggtttcgaa ggtaaaaaag acgctggcta tgttattaat   503640
ctatcaaaag atacctttat aaaacctgta ttcaagaaaa tagaggagaa aaaggaggaa   503700
gaaaataaac ctacttttga tgtatcgaaa aagaaagata acccacaagt aaaccatagt   503760
caattaaatg aaagtcacag aaaagaggat ttacaaagag aagagcattc acaaaaatct   503820
gattcaacta aggatgttac agctacagtt cttgataaaa acaatatcag tagtaaatca   503880
actactaaca atcctaataa gttgccaaaa actggaacag caagcggagc ccagacacta   503940
ttagctgccg gaataatgtt tatagtagga atttttcttg gattgaagaa aaaaaatcaa   504000
gattaagata aaagctatag aaaaaaatgg tttatgtact gagattagat agtgaggtga   504060
tgacatagtt ttgtgaaaat agccatttat aactcaatta tttagtttac tttactttac   504120
tagtgatact atttggagtt attaatggac ttagtttata taactaatga attgattgaa   504180
agggttagta ttgacaatat tggtcatatt gactagaaaa tagagtctat caaaatttaa   504240
aggctaatag aggtgatgag acaatttcgg ctctttgtca actgtagtgg gttgaagtca   504300
gctaagctcg agaaaggaca aattttgtcc tttctttttt gatattcaga gcgataaaaa   504360
tccgtttttt gaagttttca aagtttcgaa aaccaaaggc attgcgcttg ataagtttga   504420
tgagattatt ggtcgcttcc agtttggcat tagaatagtg tagttgaagg gcattgacaa   504480
tcttctcttt atctttgagg aaggttttag aggatgaact tgattcagat tgtcctcaat   504540
gagtccgaaa aatttgtcag gctccttatt ctgaaagtga aaaagcaaga gttgatagag   504600
attatagtgg tgtttcaagt cttctgaata gctcaaaagt ttatctatag tagattgaaa   504660
ctagaatagt acacctctgc ttctaaaaca ttgttagaaa tcgatttgac tgtcctgaat   504720
gatttgtcct gttattattt cattttacta taaatccacg tttacgaatc tctttccaca   504780
cttgttcaat ggggttcatc tctggtgtgt atggaggaat aaatgcaaaa ccaatattag   504840
tcggaatctt taaggtactt gatttatgcc atatagcatt gtccataacg agtaaaagat   504900
aatcatctgg ataagcttgt gaaagctcct attcctaaag cccctttata acctcttgcg   504960
agagagacta ttgactcagc ccttacttca tgcggatgaa acttcttatc gggttctaga   505020
gagtcatagc catctgacct actattggac ctttttgtct gggaaagttg agaatcaagc   505080
aatcacgctg taccatcatg atcagagtcg gagtggttcg gtagtacaag aattcctagg   505140
agattattct ggctatgttc attgtgatat gttgcggcag taacttagga ctttagtcct   505200
ctagttctgc ctatgcgata gcagtccaag gtttaggagc aaggcgacgc taagcttggt   505260
aaactgcgaa ccgctagaag cttatcgtca actggaagaa gctgaacttg ttggatgttg   505320
ggcgcatgtg agaaggaaat tttttgaagc gacccccaag caagcagata aatcatcctt   505380
aggagctaaa ggtttagctt attgtgatca gttattttcc ttggaaatag actgggaggc   505440
tttgccagct gatgaacgac tacagaaacg tcaagaacat ctccagcccc taatggaaga   505500
cttctttgct tggtgccgcc gtcagtcagt tttagcaggt tcaaaactag gaagggcaat   505560
tgaatacagc ctcaagtatg aagaaacctt taagactatt ttgaaagacg gacatctggt   505620
cctttccaat aatctagctg aacgcgccat taaatcattg gttatgggac ggagtaaaag   505680
agtccagtgg actcttttag cctgagctca gtttaaaaaa gcgagggtgg ttattttctc   505740
aaagttttga aggagctaaa gcaagagcta ttgttatgag cttgttggaa acagctaaac   505800
gtcatcaatt atagtgcgtt gaatctataa cagtacgcat cgactgctaa aacatttcta   505860
taaatcaatt ttcctttcct aatcgatttg ttcatatctt atttcaatcc attataaata   505920
gcgagaaata tctatcctat cttctagaat gtcttccaaa cgaggaaact ctcgtaaaca   505980
aagaggtttt agaggtttat ttaccatgga ctaaagttgt acaagaaaag tgcaaataag   506040
aaatctccag attaggaact atccgtgagt tcactaatct ggagattttt caatagactt   506100
cgttattggg cggttacgat atgatcactg acttcgtcag tcttatctac aacctcaaaa   506160
cagtgttttg agcaacctgc gactagcttc ctagtttact ctttgatttt cattgaatat   506220
tagaacagaa aaaatgcttg gagtatttgt ttgtgtgttt atttttatat aacaaactat   506280
aaacaaaata aaaatataaa aaaagagaca aaaaagaaca gaaagtaatt gacaacggtt   506340
tcatatagtg ttatacttat ggcataaagt taatggaaag aagggaaaaa cttatggtat   506400
tagattattt ctttgacaaa aaccttgtgt tttgcttaga agcggatagt caagaacaac   506460
tctttgatca ggttgcaact ttattggaag aacgagaaat tgtcactcca acttatcgtg   506520
aagccttgat cacgcgtgaa aagtcatttc caactggttt agatatggaa tttctaggaa   506580
aggacttgcc aaatgtagcg attcctcaca cagatattgt tcataatcta gctgagaaag   506640
tggtggttgt tcgattagaa aaaccaataa cttttcacaa tatgatagct cctgataagg   506700
aagtagaagt atccctactc ttctttatca ttaataattc aagttcaagt caaacgaaca   506760
ttcttgctca gttaatggac ttcttcacag gaaatggtca tcttgaagac ctatcaaaaa   506820
tttctgaacc agaagccctt tatacttaca ttgctgaagc aaccgcttaa tcttgtctat   506880
taaaaaataa aatcggagga aatctaaatg attaaaattc ttgctgcctg cggtgcaggt   506940
gttaactcaa gtcaccaaat taaaagtgct ctagaagaag aactttcaaa ccgtggttat   507000
gatgttcact gtgatgcagt catggtgaaa gatgtaaacg aagaccttat gaaaggttac   507060
gatatcttta caccaatcgc tgcaacagac cttggttttg aaccaggtat cccagttatc   507120
gaagctgggc caatcttatt ccgtatccca gcaatgagcg ctccagtatt tgacaatatt   507180
gaagcagcta ttaaagaaca cggattaagc taattctaat ttgttaacat tcatataaca   507240
tcaaaaaggg aggaactgtt atggatgcaa tctttgacct aatcggaaag gttttcaatc   507300
ccatcttaga aatgggtgga cctgtcatca tgttaatcat tttgacagta ttggctttac   507360
tttttggagt gaaattctcc aaagcgcttg aaggtggtat caaacttgcc atcgctctta   507420
caggtatcgg tgctatcatc ggtatgctaa acactgcttt ctcagcatca ctagcaaaat   507480
tcgttgaaaa cactggtatc caattgagta ttaccgacgt tggttgggca ccacttgcta   507540
caatcacttg gggttctgct tggacactat acttcttgct catcatgttg attgtcaaca   507600
tagtgatgct agctatgaag aaaacagata cacttgatgt cgatatcttt gatatctggc   507660
acttgtctat cacaggtctc ttgattaaat ggtatgctga taacaatggt gtgagtcaag   507720
gggtttcact ctttattgct acagcagcta tcgtccttgt cggtgtgttg aaaattatca   507780
actctgactt gatgaaacct acatttgatg accttcttaa cgccccaagt tcatcaccaa   507840
tgacatcaac tcacatgaac tacatgatga acccagttat catggttttg gataagattt   507900
ttgaaaaatt cttcccaggc cttgataaat atgactttga tgctgctaaa ttgaacaaga   507960
aaatcggttt ctggggatct aaattcttca tcggtttcat ccttggtatc gttatcggta   508020
ttatgggaac tccacatcca attgcaggtg ttgcagatgc agataaatgg cgtcttgtta   508080
tcaaaggatg gttgtctctt ggtttgactg ccggtgtatc tttggaactc ttctcactta   508140
tcggttcatg gttcatcgca gccgtagaac cactatcaca aggtattaca aacgttgcta   508200
ctaaacgtct tcaaggacgt aaattcaata tcggtcttga ctggccattc atcgctggtc   508260
gtgctgaaat ctgggcttgt gccaacgtac ttgcaccaat catgttgatt gaagcagtgc   508320
ttctttcaaa agttggaaat ggtatcttgc cacttgcagg tatcatcgct atgggtgtta   508380
ctccagctct cttggttgta actcgtggta aattgctccg tatgattatc ttcggaacac   508440
tcttgttgcc actcttcctt ctttcaggta cacttattgc accatttgca acagaacttg   508500
ctaaaggtgt aggtgccttc ccagaaggtg tgagccaaac tcaattgatt actcactcta   508560
ctcttgaagg accaatcgaa aaacttcttg gttggacaat tggtaacact acaactggtg   508620
atatcaaagc aatccttggt gcagtagtct tccttgtatt ctatatcggt atctttgctt   508680
ggtacagaaa acaaatgatc aaacgtaacg aagagtacgc agcaaaagca aaataatgcg   508740
ctcctataaa atataaactc aatgaaaatc aaagagcaaa ctaggaagct agccgcaggt   508800
tgctcaaaac acagttttga ggttgtagat aagactgacg aagtcagctc aaaacatggt   508860
tttgaggttg tagatgaaac tgacgaagtc agctcaaaac atggttttga ggttgtagat   508920
gaaactgacg aagtcagctc aaaacatggt tttgaggttg tagatgaaac tgacgaagtc   508980
agtaatcata tctacggcaa ggcgacactg acgaagtttg aattggattt tcgcagagtg   509040
taaattgttg aaactaggtt gtcataccat gtataccact tgggctttgg tagtagctaa   509100
ctgcactaaa tataatataa ggagggtttt atggggaaag gccattggaa tcggaaaaga   509160
gtttatagca ttcgtaagtt tgctgtggga gcttgctcag taatgattgg gacttgtgca   509220
gttttattag gaggaaatat agctggagaa tctgtagttt atgcggatga aacacttatt   509280
actcatactg ctgagaaacc taaagaggaa aaaatgatag tagaagaaaa ggctgataaa   509340
gctttggaaa ctaaaaatat agttgaaagg acagaacaaa gtgaacctag ttcaactgag   509400
gctattgcat ctgagaagaa agaagatgaa gccgtaactc caaaagagga aaaagtgtct   509460
gctaaaccgg aagaaaaagc tccaaggata gaatcacaag cttcaaatca agaaaaaccg   509520
ctcaaggaag atgctaaagc tgtaacaaat gaagaagtga atcaaatgat tgaagacagg   509580
aaagtggatt ttaatcaaaa ttggtacttt aaactcaatg caaattctaa ggaagccatt   509640
aaacctgatg cagacgtatc tacgtggaaa aaattagatt taccgtatga ctggagtatc   509700
tttaacgatt tcgatcatga atctcctgca caaaatgaag gtggacagct caacggtggg   509760
gaagcttggt atcgcaagac tttcaaacta gatgaaaaag acctcaagaa aaatgttcgc   509820
cttacttttg atggcgtcta catggattct caagtttatg tcaatggtca gttagtgggg   509880
cattatccaa atggttataa ccagttctca tatgatatca ccaaatacct tcaaaaagat   509940
ggtcgtgaga atgtgattgc tgtccatgca gtcaacaaac agccaagtag ccgttggtat   510000
tcaggaagtg gtatctatcg tgatgtgact ttacaagtga cagataaggt gcatgttgag   510060
aaaaatggga caactatttt aacaccaaaa cttgaagaac aacaacatgg caaggttgaa   510120
actcatgtga ccagcaaaat cgtcaatacg gacgacaaag accatgaact tgtagccgaa   510180
tatcaaatcg ttgaacgagg tggtcatgct gtaacaggct tagttcgtac agcgagtcgt   510240
accttaaaag cacatgaatc aacaagccta gatgcgattt tagaagttga aagaccaaaa   510300
ctctggactg ttttaaatga caaacctgcc ttgtacgaat tgattacgcg tgtttaccgt   510360
gacggtcaat tggttgatgc taagaaggat ttgtttggtt accgttacta tcactggact   510420
ccaaatgaag gtttctcttt gaatggtgaa cgtattaaat tccatggagt atccttgcac   510480
cacgaccatg gggcgcttgg agcagaagaa aactataaag cagaatatcg ccgtctcaaa   510540
caaatgaagg agatgggagt taactccatc cgtacaaccc acaaccctgc tagtgagcaa   510600
accttgcaaa tcgcagcaga actaggttta ctcgttcagg aagaggcctt tgatacgtgg   510660
tatggtggca agaaacctta tgactatgga cgtttctttg aaaaagatgc cactcaccca   510720
gaagctcgaa aaggtgaaaa atggtctgat tttgacctac gtaccatggt cgaaagaggc   510780
aaaaacaacc ctgctatctt catgtggtca attggtaatg aaataggtga agctaatggt   510840
gatgcccact ctttagcaac tgttaaacgt ttggttaagg ttatcaagga tgttgataag   510900
actcgctatg ttaccatggg agcagataaa ttccgtttcg gtaatggtag cggagggcat   510960
gagaaaattg ctgatgaact cgatgctgtt ggatttaact attctgaaga taattacaaa   511020
gcccttagag ctaagcatcc aaaatggttg atttatggat cagaaacatc ttcagctacc   511080
cgtacacgtg gaagttacta tcgccctgaa cgtgaattga aacatagcaa tggacctgag   511140
cgtaattatg aacagtcaga ttatggaaat gatcgtgtgg gttgggggaa aacagcaacc   511200
gcttcatgga cttttgaccg tgacaacgct ggctatgctg gacagtttat ctggacaggt   511260
acggactata ttggtgaacc tacaccatgg cacaaccaaa atcaaactcc tgttaagagc   511320
tcttactttg gtatcgtaga tacagccggc attccaaaac atgacttcta tctctaccaa   511380
agccaatggg tttctgttaa gaagaaaccg atggtacacc ttcttcctca ctggaactgg   511440
gaaaacaaag aattagcatc caaagtagct gactcagaag gtaagattcc agttcgtgct   511500
tattcgaatg cttctagtgt agaattgttc ttgaatggaa aatctcttgg tcttaagact   511560
ttcaataaaa aacaaaccag cgatgggcgg acttaccaag aaggtgcaaa tgctaatgaa   511620
ctttatcttg aatggaaagt tgcctatcaa ccaggtacct tggaagcaat tgctcgtgat   511680
gaatctggca aggaaattgc tcgagataag attacgactg ctggtaagcc agcggcagtt   511740
cgtcttatta aggaagacca tgcgattgca gcagatggaa aagacttgac ttacatctac   511800
tatgaaattg ttgacagcca ggggaatgtg gttccaactg ctaataatct ggttcgcttc   511860
caattgcatg gccaaggtca actggtcggt gtagataacg gagaacaagc cagccgtgaa   511920
cgctataagg cgcaagcaga tggttcttgg attcgtaaag catttaatgg taaaggtgtt   511980
gccattgtca aatcaactga acaagcaggg aaattcaccc tgactgccca ctctgatctc   512040
ttgaaatcga accaagtcac tgtctttact ggtaagaaag aaggacaaga gaagactgtt   512100
ttggggacag aagtgccaaa agtacagacc attattggag aggcacctga aatgcctacc   512160
actgttccgt ttgtatacag tgatggtagc cgtgcagaac gtcctgtaac ctggtcttca   512220
gtagatgtga gcaagcctgg tattgtaacg gtgaaaggta tggctgacgg acgagaagta   512280
gaagctcgtg tagaagtgat tgctcttaaa tcagagctac cagttgtgaa acgtattgct   512340
ccaaatactg acttgaattc tgtagacaaa tctgtttcct atgttttgat tgatggaagt   512400
gttgaagagt atgaagtgga caagtgggag attgccgaag aagataaagc taagttagca   512460
attccaggtt ctcgtattca agcgaccggt tatttagaag gtcaaccaat tcatgcaacc   512520
cttgtggtag aagaaggcaa tcctgcggca cctgcagtac caactgtaac ggttggtggt   512580
gaggcagtaa caggtcttac tagtcaaaaa ccaatgcaat accgcactct tgcttatgga   512640
gctaagttgc cagaagtcac agcaagtgct aaaaatgcag ctgttacagt tcttcaagca   512700
agcgcagcaa acggcatgcg tgcgagcatc tttattcagc ctaaagatgg tggccctctt   512760
caaacctatg caattcaatt ccttgaagaa gcgccaaaaa ttgctcactt gagcttgcaa   512820
gtggaaaaag ctgacagtct caaagaagac caaactgtca aattgtcggt tcgagctcac   512880
tatcaagatg gaacgcaagc tgtattacca gctgataaag taaccttctc tacaagtggt   512940
gaaggggaag tcgcaattcg taaaggaatg cttgagttgc ataagccagg agcagtcact   513000
ctgaacgctg aatatgaggg agctaaagac caagttgaac tcactatcca agccaatact   513060
gagaagaaga ttgcgcaatc catccgtcct gtaaatgtag tgacagattt gcatcaggaa   513120
ccaagtcttc cagcaacagt aacagttgag tatgacaaag gtttccctaa aactcataaa   513180
gtcacttggc aagctattcc gaaagaaaaa ctagactcct atcaaacatt tgaagtacta   513240
ggtaaagttg aaggaattga ccttgaagcg cgtgcaaaag tctctgtaga aggtatcgtt   513300
tcagttgaag aagtcagtgt gacaactcca atcgcagaag caccacaatt accagaaagt   513360
gttcggacat atgattcaaa tggtcacgtt tcatcagcta aggttgcatg ggatgcgatt   513420
cgtccagagc aatacgctaa ggaaggtgtc tttacagtta atggtcgctt agaaggtacg   513480
caattaacaa ctaaacttca tgttcgcgta tctgctcaaa ctgagcaagg tgcaaacatt   513540
tctgaccaat ggaccggttc agaattgcca cttgcctttg cttcagactc aaatccaagc   513600
gacccagttt caaatgttaa tgacaagctc atttcctaca ataaccaacc agccaatcgt   513660
tggacaaact ggaatcgtac taatccagaa gcttcagtcg gtgttctgtt tggagattca   513720
ggtatcttga gcaaacgctc cgttgataat ctaagtgtcg gattccatga agaccatgga   513780
gttggtgtac cgaagtctta tgtgattgag tattatgttg gtaagactgt cccaacagct   513840
cctaaaaacc ctagttttgt tggtaatgag gaccatgtct ttaatgattc tgccaactgg   513900
aaaccagtta ctaatctaaa agcccctgct caactcaagg ctggagaaat gaaccacttt   513960
agctttgata aagttgaaac ctatgctgtt cgtattcgca tggttaaagc agataacaag   514020
cgtggaacgt ctatcacaga ggtacaaatc tttgcgaaac aagttgcggc agccaagcaa   514080
ggacaaacaa gaatccaagt tgacggcaaa gacttagcaa acttcaaccc tgatttgaca   514140
gactactacc ttgagtctgt agatggaaaa gttccggcag tcacagcaag tgttagcaac   514200
aatggtctcg ctaccgtcgt tccaagcgtt cgtgaaggtg agccagttcg tgtcatcgcg   514260
aaagctgaaa atggcgacat cttaggagaa taccgtctgc acttcactaa ggataagagc   514320
ttactttctc ataaaccagt tgctgcggtt aaacaagctc gcttgctaca agtaggtcaa   514380
gcacttgaat tgccgactaa ggttccagtt tacttcacag gtaaagacgg ctacgaaaca   514440
aaagacctga cagttgaatg ggaagaagtt ccagcggaaa atctgacaaa agcaggtcaa   514500
tttactgttc gaggccgtgt ccttggtagt aaccttgttg ctgagatcac tgtacgagtg   514560
acagacaaac ttggtgagac tctttcagat aaccctaact atgatgaaaa cagtaaccag   514620
gcctttgctt cagcaaccaa tgatattgac aaaaactctc atgaccgcgt tgactatctc   514680
aatgacggag atcattcaga aaatcgtcgt tggacaaact ggtcaccaac accatcttct   514740
aatccagaag tatcagcggg tgtgattttc cgtgaaaatg gtaagattgt agaacggact   514800
gttacacaag gaaaagttca gttctttgca gatagtggta cggatgcacc atctaaactc   514860
gttttagaac gctatgtcgg tccagagttt gaagtgccaa cctactattc aaactaccaa   514920
gcctacgacg cagaccatcc attcaacaat ccagaaaatt gggaagctgt tccttatcgt   514980
gcggataaag acattgcagc tggtgatgaa atcaacgtaa catttaaagc tatcaaagcc   515040
aaagctatga gatggcgtat ggagcgtaaa gcagataaga gcggtgttgc gatgattgag   515100
atgaccttcc ttgcaccaag tgaattgcct caagaaagca ctcaatcaaa gattcttgta   515160
gatggaaaag aacttgctga tttcgctgaa aatcgtcaag actatcaaat tacctataaa   515220
ggtcaacggc caaaagtctc agttgaagaa aacaatcaag tagcttcaac tgtggtagat   515280
agtggagaag atagctttcc agtacttgtt cgcctcgttt cagaaagtgg aaaacaagtc   515340
aaggaatacc gtatccactt gactaaggaa aaaccagttt ctgagaagac agttgctgct   515400
gtacaagaag atcttccaaa aatcgaattt gttgaaaaag atttggcata caagacagtt   515460
gagaaaaaag attcaacact gtatctaggt gaaactcgtg tagaacaaga aggaaaagtt   515520
ggaaaagaac gtatctttac agcgattaat cctgatggaa gtaaggaaga aaaactccgt   515580
gaagtggtag aagttccgac agaccgcatc gtcttggttg gaaccaaacc agtagctcaa   515640
gaagctaaaa aaccacaagt gtcagaaaaa gcagatacaa aaccaattga ttcaagtgaa   515700
gctagtcaaa ctaataaagc ccagttacca agtacaggta gtgcggcaag ccaagcagca   515760
gtagcagcag gtttaactct tctaggtttg agtgcaggat tagtagttac taaaggtaaa   515820
aaagaagact agaaattttg ataccttctt tatcattaaa gaccaaagaa aaactcttgt   515880
cctaaataga agataaagag cctgagacaa aatagttctc aaccacaaaa aagctagata   515940
tttccaattg tggaactcta gctttttaat tttgagtcat tctcttattg tatagtagat   516000
tgaaactaga atagtacact tttacttcta aaacattgtt agaaatcgat ttgattgtcc   516060
ttatcgattt gtcctgttct tatttcattt tactatattt taggaggtta ttggccataa   516120
gtaccaatcc catgtcaatt ctcacttgac gcttccctct cagattacat ctcttgtaac   516180
ccaaagaagc ctttatctgc ccaaagacag gttccacatc aatcttgcgt tgagcgaaaa   516240
tctgtctacc ttggggagat aaaagcgcct gacattcttt agctttcaag ttttgatagc   516300
gttcgttcat atacagtccc ttttgagggg ctgattcagg ttcgtcggcg tagtaaacct   516360
tgatttcttg ttgaaagtct gtctgtgttt tctgatattt ggtatggtga aaacgataat   516420
accagccatc aggatgtgtg tagctatcct ccttgtcatt atagtgccaa ttcgctaagt   516480
ttttagctga ctctttatac cctctctttt gtttcttatc aaacatggca tatttaatca   516540
gaaggggagt gatttcttct tgaaaataga cctgtatctg ttcttgaagt ttggcggaga   516600
atttctctgt cgttttcttc cacacaaaac tatacttgtt ggcattggct tcaatcttag   516660
ttctgtcaat aaacaaacaa tctaaggtca ctaactcttc catttttcaa tttttcgacc   516720
agagaaaatc ccttgtgaat aggcaaatag aagagtagat acaagcattt tagggtgata   516780
agacgggcga tcaaaggcat gataggaggt gtagaagtga cgttcctcca aggtattcac   516840
cactttttca atagtaaaaa cgagatgatc ttgtggtaag aaggaactga tttctagtgg   516900
taaagttgtt tgatttgtgt tatagtgaat atgcatggga tagcctttct aaatggttta   516960
ttgggcaatt ctattttacc aagactatcg taaccatcca aaaaagcaac ggcaaatccg   517020
ttgccttttt ggatataaga gactattgtc ccagactctt ttctttgtat aaaattgtat   517080
agtgttattg tctatactat tttgtagaga aagcaaaaat ccctagaaaa tgcttaggga   517140
ttcgactatt tcattaagaa caattcaaca atcatttcta tatacatgat aagggttaat   517200
aagaatcctg cacgccagaa gaatttgata aatttagggt agtaaaagct gcgttttttc   517260
aaaaggaaga aaaagacgag aataatggct aggatcgaga gggctagccc cagtctaggg   517320
aggaaattat gggtaaaggt tttagctgta atcaagtaat actcaaatac caagactgga   517380
aaagccaaat ccgcaaagtt tcgtcctagt ttttttaatc taaaaagttt ggttaggata   517440
atgcagacga ctaaggtcag tatcaataat aaaatagatg ctaatttcat taaaatcata   517500
cccatattgt atcataaaaa aaggctaatg gaaacgagaa acagaggaat ttataggaaa   517560
gtcaggcttt tgagattgtg ggtgattttt gttataatga aagtcatgaa atcttataat   517620
accttgaatg attattatcg aaaactcttt ggagaaaaga cttttaaagt ccctattgat   517680
gcgggatttg attgtcccaa tcgtgatggg actgtggctc atgggggctg tactttttgt   517740
acggtttctg gttctggaga tgccattgtg gcaccggatg cgcctatccg tgagcaattt   517800
tataaggaaa ttgactttat gcaccgcaag tggccggatg ttcggaagta tctggtttat   517860
tttcaaaatt ttaccaacac ccatgaaaag gtggaagtta ttcgagagcg ttatgaacag   517920
gctatcaatg agccaggtgt ggtaggaatc aatattggaa cgcgcccaga ctgtttacca   517980
gacgaaacca tcgaatattt ggctgagtta tcggagtgca tgcatgtgac ggttgaattg   518040
ggcttgcaaa ctacttatga agcaacctct gacctgatta accgtgcgca ttcttatgaa   518100
ttgtaggtgg aaacggtcaa gcgtttgaga aagtatccaa aaattgagat tgtttcccat   518160
ttgatcaatg gtttgcctgg tgaaacccat gagatgatgg ttgaaaatgt ccgccgttgt   518220
gtcacggata acgatattca agggattaaa ctgcatttgc tccatcttat gacaaatact   518280
cgtatgcaac gagattacca tgaggggcgt ttacaattga tgagtcagga cgaatatgtc   518340
agggtcatct gtgaccaact ggaaattatt cccaaacata tcgtcatcca tcgaattaca   518400
ggagatgcgc ctagggatat gctgcttggt cctatgtgga gcctcaataa atgggaagtc   518460
ctcaacagca ttgagatgga gatgcgacgt cgtggaagtg ttcaaggatg caaggctgta   518520
aaacaggagt ttgaaaatga aaagaccact tgagatggca catgattttt tggctgaggt   518580
cgtgacaaaa gaggatgtcg tagtggatgc gactatggga aatggtcatg acacgctttt   518640
tttagccaag ctagccaagc aagtctatgc ctttgatatt cagaagcaag ccttggaaaa   518700
gacccaagag cgtttgcatc aggctgactt gacaaatgcc cagttaatct tgcaaggcca   518760
tgagacactg gaccagtttg tgataaaagc taaggcaggg atttttaatc tgggctattt   518820
gccggcagct gataagtctg tcatcacccg accgcagaca acgattgagg cattagaaaa   518880
gctatgtggc ttacttgtca aaggtggacg aattgctatt atgatttact atggtcatga   518940
aggaggcgat ctcgagagag atgctgtctt ggattttgtg atccagttga accaacaaga   519000
gtacacagct gccatttacc gaactttaaa ccaagtcaac aacccgccgt ttttagtgat   519060
gattgaaaaa ttagagagat acagacatgg ataaacaata cttacacgaa aagctggatg   519120
ccatgcgcca gaattttgtt gaatcaaccc accacgaacg agcgatgggc gtgctagacc   519180
aagcgcatat gagcaaaaaa atgcttaaaa tcaagaaaaa attagttgct cttgaaatgg   519240
aacggtgcca gagaaaaatt gagcacaaag actgttccaa gattgaccaa aaaatcaaag   519300
agcagaagga gatatttgaa tcctgttgta aaaaagatta aggaggacgt gcgtggaatt   519360
actgatttac ctcatcctat ttttactggt tttgattgtc tcaagtacaa ccaataagct   519420
cctgcccttt ttgcctctcc ctttggtgca aattcttttg ggaattgtga ttggtctctt   519480
tttacccaat actgactttc accttaatac ggagttgttt ttggcactgg ttatcggacc   519540
cttgcttttc cgagaggctg aagaagcaga tgttacggct attttaaaac actggcgaat   519600
cattgtttat ctcatatttc cagtgatttt tatctcgacc ctgagtttgg gtggcttggc   519660
ccatcttctt tggttcagcc ttcccttggc agcttgcttg gctgttgggg cagcccttgg   519720
tcctacggac ttggtggcct ttgcctctct ttcggagcgt tttagctttc ctaagcgcgt   519780
gtccaatatt cttaagggcg aaggactctt gaatgatgct tctggtttgg tggcttttca   519840
ggtagctttg acagcttgga caactggagc tttttctctg gggcaagcta gcagttcgct   519900
catcttttca atcctaggcg gttttttaat tggattttta acagccatga ccaaccgctt   519960
cctccatacc ttcttgctaa gtgtgcgcgc aacggatatt gccagtgaac ttttattaga   520020
attgagtttg cctctagtga ccttctttct ggcagaagaa gttcatgttt caggtattat   520080
tgccgtcgta gttgctggaa ttttaaaggc aagtcgcttc aagaaaatca cgctcctcga   520140
agcccaagtg gatacggtga ccgagacggt ctggcataca gtgaccttta tgctcaacgg   520200
ttctgtcttt gtgattttag ggatggagtt ggaaatgata gcagaaccta tcttgaccaa   520260
tccaatctat aatcctctac ttttattgct atctcttatc gcccttacct ttgtcctttt   520320
tgtcattcgt tttattatga tctatggcta ttatgcctat agaacccgac gcctcaagaa   520380
aaagctaaat aagtatatga aggacatgtt tctcttgacc ttttcaggtg ttaagggaac   520440
ggtgtcgatt gctacgattc tcttgatacc aagtaattag aacaggagta tcctcttttg   520500
cttttccttg ttgcaggtgt gacgcttgtt agctttttaa caggtctctt ggtcttgcct   520560
catctttctg atgaagagga agaaagcaag gattatctta tgcatatcgc cattttgaat   520620
gaagtaacgc tagagttgga aaaagagttg gaagacacca gaaataaact tcccctctat   520680
gcggctattg acaattatca tggacgtatt gaaaatctca ttttaagcca agaaaaccag   520740
gatgatcaag aagactgggc tgctttgaaa ctcttgattc ttagtattga aagtgatggt   520800
ttggaacagg cctatgaaga ggggaacatt agcaatcgtg cttaccgagt ttaccaacgt   520860
tatctgaaaa atatagaaca aggaatcaat cgtaaacttg cctcaagact gacctattat   520920
tttcttgttt ccttgaggat tttacgtttt ctccttcatg aagtttttac tctcggaaag   520980
accttccgta gctggaagaa caaggagcaa agccgtctcc gtgctcttga ttatgaccaa   521040
attgcagagc tctatcttgc caatacagag atgattattg aaagtttgga aaacctgaag   521100
ggagtctaca gacgctcttt gattagtttt atgcaggagt ctcgtcttcg agaaacagct   521160
attatcagca gtggtgcctt tgtcgaacgg gttatcaatc gtgtcaaacc caacaatatc   521220
gatgaaatgc tgagaggcta ttatctggag cgcaagttga ttttcgaata cgaagaaaaa   521280
cgattgatta cgactaagta tgccaagaaa ttacgacaaa atgtaaataa cttagagaac   521340
tattccttga aggaagctgc caatacccta ccgtatgata tggtggaatt ggtaagaaga   521400
aattagttaa tactcttcga aaatctcttc aaaccacgtc agcgtcgcct taccgtatgt   521460
atgtgactga cttcgtcagt cttatctaca acctcaaaac agtgttttga gcagcttgcg   521520
gctagctttc tagtttgctc tttgattttc attgagtata agattataag tgaaggagta   521580
tgacatgaaa aagtggtgga aagagctgat agacaaacct ttattaaaag cttttttgca   521640
ttattatcaa gcatcagata gtgagttgac cagtgtcgca gtagcctact attggttgat   521700
ttcgattttc cccctgcttt tggtggtggt caatatcctc ccctattttc agattcctgt   521760
gggagaattt ttgggcttta tgaaagacgt cctgccccca agcctctatg aaggtgtgga   521820
aaaaatagcc agagaagtct tgacgcaacc ttcaacaggt ttattgagtt tttctgtttt   521880
atcggcgtta tggagttttt caaaatctat gaatttcttg caaaaagctt ttaacaaggc   521940
ttatggcgtc gaaaagagtc gtggacttat ttcccatcag atgctaagtc tcctagtcag   522000
ttttggcttg cagctcctct ttgcgtttgc cttgtttttg atcttatttg gtcagatgat   522060
tttggcttta cttgctcatt attggacaaa agatggcatt atctatcagg ctttacaagg   522120
gttggcaggt cctctgattt acgccctcct ctttgctatc ttggtcatgc tttattattt   522180
tcttcccaat ctatctaaca ggaaaattag ctatacccta ccaggcagtg cctttgttct   522240
cttagtgatt ttaggtttac taactctgtt ctctagttat ctcaattact atgtccatca   522300
tttggtggat gtccgaattt taggttccgt tcttcttgtt gttatgatgt tttggtttat   522360
cttgattgct aaaattgtta tcctaggcgc ggtgatcaat gccagtatgc agagtttgaa   522420
agatccggtc tttaaaaaag actaactatt tatccattac aaaagcgcat agtatcaagg   522480
ctttatagaa tcttgatact atgcgctttt gtgctttgac agttttttgt atagtttttg   522540
tccaagattt ctaaatcatc tgattaaatt cctattttcc cctatcattg tccctgtttt   522600
ttcgaaaatg gaaggagtat aataaatcta tcaataaaat gataggagga actttatggg   522660
tcatattttc ttttttctaa gtgtcttttt ggcagggatt ctatccttct tttctccttg   522720
tatcttacct ttgttaccgg tctatacagg agtgttacta gatgataagg atggtgctca   522780
ggcttctagc ggcaaatttt caatctcagt tactagttta ttacgaactc tggcctttat   522840
agcaggaatt tcctttatat ttattttgtt gggctatgga gctggttttt taggcgattt   522900
gctttatgct tcttggttcc aatatcttac tggggcaatt attatccttc ttggtttgca   522960
ccaaatggag attctacact ttaaggggct ttataaggaa aagaggctac aactgcaagg   523020
acaggggcaa aatggtaagg gctatagtca ggcattttta ttgggcttga cctttagttt   523080
tgcttggacg ccttgcgtgg ggccggttct ggggtctgtt ttggccttgg cggcttcagg   523140
tggttcagga gcttggcagg gagctggtct catgttggtg tatacgctgg gcttggcgct   523200
accattcttg cttctagctc tgacctctag ttatgttttg aaacatttcc gaaaacttca   523260
tccctatctc ggaatcctca aaaaagtggg tggttttctc attattgtga tgggcttctt   523320
ggttctgttt ggaaatgctt caattttaag tcaattattt gaataaaatg gaaaggaata   523380
tcaatatgaa aaaatggcaa acatgtgttc ttggagcagg ttcgctcctt tgtttgacgg   523440
cttgttcagg caagtccgtg actagtgaac accaaacgaa agatgaaatg aagacggagc   523500
agacagctag taaaacaagc gcagctaaag ggaaagaggt ggctgatttt gaattgatgg   523560
gagtagatgg caagacctac cgtttatctg attacaaggg caagaaagtc tatctcaaat   523620
tctgggcttc ttggtgttcc atctgtctgg ctagtcttcc agatacggat gagattgcta   523680
aagaagctgg tgatgactat gtggtcttga cagtagtgtc accaggacat aagggagagc   523740
aatctgaagc ggactttaag aattggtata agggattgga ttataaaaat ctcccagtcc   523800
tagttgaccc atcaggcaaa cttttggaaa cttatggtgt ccgttcttac ccaacccaag   523860
cctttataga caaagaaggc aagctggtca aaacacatcc aggattcatg gaaaaagatg   523920
caattttgca aactttgaag gaattagcct aggaggcgtc ttatgaatga taagttaaaa   523980
atcttcttgt tgctaggagt attttttcta gccataaccg gtttctatgt tctattgata   524040
cgaaatgcag ggcagacaga tgcctcgcaa attgaaaagg cggcagttag ccaaggagga   524100
aaagcagtga aaaaaacaga aattagtaaa gacgcagact tgcacgaaat ttatctagct   524160
ggaggttgtt tctggggagt ggaggaatat ttctcacgtg ttcccggggt gacggatgcc   524220
gtttcaggct atgcaaatgg tagaggagaa acaaccaagt acgaattgat taaccaaaca   524280
ggtcatgcag aaaccgtcca tgtcacctat gatgccaagc aaatttctct caaggaaatc   524340
ctgcttcact atttccgcat tatcaatcca accagcaaaa ataaacaagg aaatgatgtg   524400
gggacccagt accgtactgg tgtttattac acagatgaca aggatttgga agtgattaac   524460
caagtctttg atgaggtggc taagaaatac gatcaacctc tagcagttga aaaggaaaac   524520
ttgaagaatt ttgtggtggc tgaggattac catcaagact atctcaagaa aaatccaaat   524580
ggctactgcc atatcaatgt taatcaggcg gcctatcctg tcattgatgc cagcaaatat   524640
ccaaaaccaa gtgatgagga attgaaaaag accctgtcac ctgaggagta tgcagttacc   524700
caggaaaatc aaacagaacg agctttctca aaccgttact gggataaatt tgaatccggt   524760
atctatgtgg atatagcaac tggggaacct ctcttttcat caaaagacaa atttgagtct   524820
ggttgtggct ggcctagttt tacccaaccc atcagtccag atgttgtcac ctacaaggaa   524880
gataagtcct acaatatgac gcgtatggaa gtgcggagcc gagtaggaga ttctcacctt   524940
gggcatgtct ttacggatgg tccacaggac aagggcggct tacgttactg tatcaatagc   525000
ctctctatcc gctttattcc caaagaccaa atggaagaaa aaggctacgc ttatttacta   525060
gattatgttg attaatactc ttcgaaaatc tcttcaaacc acgtcagcgt cgccttaccg   525120
tatgtagggt tactgacttc gtcagtttta tctacaacct caaagctata ctttgagctg   525180
acttcgtcag ttttatttac aacctcaaag cggtactttg agaaacctgt ggctatcttc   525240
ctagtttact ttttgatttt tattgagtat aagaggtctt tcctaagcag ttagaggaga   525300
attttgctat actgatacta gtaagtggta aaggagcaga gcatgaccta cacaatctta   525360
atcgtagaag atgaatatct ggtaagacaa ggtttgacta aactggtcaa tgtagcagcc   525420
tacgatatgg aaatcatcgg tcaggctgaa aatggaaggc aggcttggga attgatccaa   525480
aagcaggtgc cagatatcat tttaaccgat atcaacatgc ctcatctaaa tggcatccag   525540
ttggccagtc tggtacgaga aacctatcct caggttcatt tggtcttttt aacaggttac   525600
gatgattttg attatgcctt gtctgctgtc aaactaggtg tggacgacta cctgctcaaa   525660
cccttttctc gtcaggatat tgaggaaatg ttggggaaaa tcaaacaaaa actagacaag   525720
gaagagaaag aagagcagtt acaagattta ttgactaata ggtttgaagg aaacatggcc   525780
cagaaaatcc agtctcatct ggctgatagc caatttagtt taaagtcttt agccagtgac   525840
ttaggtttta gtccgaccta tctgagttcc ttgattaaga aagagttggg cttgcctttt   525900
caggattatc tggtgagaga acgtgttaaa caagccaagc tcttgctttt aactacagat   525960
ctgaagattt atgagatcgc agagaaggtt ggttttgaag atatgaacta ttttacccaa   526020
cgttttaagc agattgcagg tgtgacacct cgtcagttta agaagggaga agaccgatga   526080
agcgttcttc tcttttagtt agaatggtta tttccatctt tctggtcttt ctcattctcc   526140
tagctctggt tggaactttc tactatcaat caagttcttc agccattgag gccaccattg   526200
agggcaacag ccaaacgacc atcagccaga ctagccactt tattcagtct tatatcaaaa   526260
aactagaaac cacctcgact ggtttgaccc agcagacgga tgttctggcc tatgctgaga   526320
atcccagtca agacaaggtc gagggaatcc gagatttgtt tttgaccatc ttgaagtcag   526380
ataaggactt gaaaactgtt gtgctggtga ccaaatctgg tcaggtcatt tctacagatg   526440
acagtgtgca gatgaaaact tcctctgata tgatggctga ggattggtac caaaaggcca   526500
ttcatcaggg agctatgcct gttttgactc cagctcgtaa atcagatagt cagtgggtca   526560
tttctgtcac tcaagaactt gttgatgcaa agggagccaa tcttggtgtg cttcgtttgg   526620
atatttctta tgaaactctg gaagcctatc tcaatcaact ccagttgggg cagcagggct   526680
ttgccttcat tatcaatgaa aaccatgaat ttgtctacca tcctcaacac acagtttata   526740
gttcgtctag caaaatggag gctatgaaac cctacatcga tacaggtcag ggttatactc   526800
ctggtcacaa atcctacgtc agtcaagaga agattgcagg aactgattgg acggtgcttg   526860
gcgtgtcatc attggaaaag ttagaccagg ttcggagtca gctcttgtgg accttgcttg   526920
gggccagtgt cacatctctt cttgtctgtc tctgcttagt gtggttcagt cttaaacgct   526980
ggattgctcc tttgaaggat ttgagagaaa ccatgttgga aattgcttct ggtgctcaaa   527040
atcttcgtgc caaggaagtt ggtgcctatg aactgagaga agtaactcgc caatttaatg   527100
ctatgttgga tcagattgat cagttgatgg tagctattcg tagccaggaa gaaacgaccc   527160
gtcagtacca acttcaagcc ctttcgagcc agattaatcc acatttcctc tataacactt   527220
tggacaccat catctggatg gctgaatttc atgatagtca gcgagtggtg caggtgacca   527280
agtccttggc aacctatttc cgcttggcgc tcaatcaagg caaggacttg atttgtctct   527340
ctgacgaaat caatcatgtc cgccagtatc tctttatcca gaaacaacgc tatggagata   527400
agctggaata cgaaattaat gaaaatgttg cctttgataa tttagtctta cccaagctgg   527460
tcctacaacc ccttgtagaa aatgctcttt accatggcat taaggaaaag gaaggtcagg   527520
gccatattaa actttctgtc cagaaacagg attcgggatt ggtcatccgt attgaggatg   527580
atggcgttgg cttccaagat gctggtgata gtagtcaaag tcaactcaaa cgtgggggag   527640
ttggtcttca aaatgtcgat caacggctca aacttcattt tggagccaat taccatatga   527700
agattgattc tagaccccaa aaagggacga aagttgaaat atatataaat agaatagaaa   527760
ctagctaact cccagtcaat tctgggagtt ttatgcgtaa ttgggcaaac tttctaggtt   527820
gtctatcttg ctaaaaacaa gaaaaaacgg tatgatagaa gagtgacaac agaggtaaca   527880
gagatgaacg agacacagat tcaaagagaa acacgtcagg tagtggaaga tgttttagaa   527940
aagaccaatt tgaagcaggg ggcccttttt gttttaggtc tatcttctag tgaggtgcta   528000
ggtggtcata ttgggaaaga atccagtcaa gagattggtg agctgatagt ggagactatc   528060
ttggatattc taggtagtag aggtatccat ttagcagttc aaggttgtga gcatgtcaat   528120
cgggctctcg ttgttgaacg tcaggtggca gagcagtttg gtctggaaat tgtcagtgtc   528180
catcctactc ttcatgcagg aggttcgggg cagttggcag cctttaagtt tatgcaggat   528240
ccagttgagg ttgaatttat caaggctcat gctggattgg atatcggaga cactgcaatt   528300
ggcatgcatg tcaagcatgt tcaggttccg attcgcccta ttttgagaga gattggtcat   528360
gcccatgtaa cggcactggc tagtcgtcca aaattaatcg gaggtgcgcg tgcgcactat   528420
ccgcaagatg ctattaggaa gttttgagaa tgaataaagg agataaaagt gtttaaaaaa   528480
gaccgttttt caattcgtaa gattaaggga gttgtaggct ctgtatttct tggaagcctt   528540
ttgatggctc cttctgtagt ggacgcagcc acctatcact atgtaaataa agagattatt   528600
tcacaagaag ctaaagattt aattcagaca ggaaagcctg acaggaatga agttgtatat   528660
ggtttggtgt atcaaaaaga tcagttgcct caaacaggga cagaagcatc tgttttgaca   528720
gcttttggtt tgctgactgt tgggagcttg cttttaatct acaagagaaa gaaaattgct   528780
agcgtctttc tagttggagc tatgggattg gtagttcttc ctagtgcagg ggctgtagac   528840
ccagttgcga ccctagcgct ggctagtcga gagggtgttg ttgaaatgga gggctatcgc   528900
tatgttggtt atctatcagg tgacatcctc aaaacgcttg gcttggacac tgttttagaa   528960
gaaacctcag caaaacctgg agaggtgact gtggtcgaag ttgagactcc tcaatcaata   529020
acaaatcagg agcaagctag gacagaaaac caagtagtag agacagagga agctccaaaa   529080
gaagaagcac ctaaaacaga agaaagtcca aaggaagaac caaaatcgga ggtaaaacct   529140
actgacgaca cccttcctaa agtagaagag gggaaagaag attcagcaga accagctcca   529200
gttgaagaag taggtggaga agttgagtca aaaccagagg aaaaagtagc agttaagcca   529260
gaaagtcaac catcagacaa accagctgag gaatcaaaag ttgaacaagc aggtgaacca   529320
gtcgcgccaa gagaagacga aaaggcacca gtcgagccag aaaagcaacc agaagctcct   529380
gaagaagaga aggctgtaga ggaaacaccg aaacaagaag agtcaactcc agataccaag   529440
gctgaagaaa ctgtagaacc aaaagaggag actgttaatc aatctattga acaaccaaaa   529500
gttgaaacgc ctgctgtaga aaaacaaaca gaaccaacag aggaaccaaa agttgaacaa   529560
gcaggtgaac cagtcgcgcc aagagaagac gaacaggcac caacggcacc agttgagcca   529620
gaaaagcaac cagaagttcc tgaagaagag aaggctgtag aggaaacacc gaaaccagaa   529680
gataaaataa agggtattgg tactaaagaa ccagttgata aaagtgagtt aaataatcaa   529740
attgataaag ctagttcagt ttctcctact gattattcta cagcaagtta caatgctctt   529800
ggacctgttt tagaaactgc aaaaggtgtc tatgcttcag agcctgtaaa acagcctgag   529860
gtaaatagcg agacaaataa acttaaaacg gctattgacg ctctaaacgt tgataaaact   529920
gaattaaaca atacgattgc agatgcaaaa acaaaggtaa aagaacatta cagtgataga   529980
agttggcaaa acctccaaac tgaagttaca aaggctgaaa aagttgcagc taatacagat   530040
gctaaacaaa gtgaagttaa cgaagctgtt gaaaaattaa ctgcaactat tgaaaaattg   530100
gttgaattat ctgaaaagcc aatattaaca ttgactagta ccgataagaa aatattggaa   530160
cgtgaagctg ttgctaagta tactctagaa aatcaaaaca aaacaaaaat caaatcaatc   530220
acagctgaat tgaaaaaagg agaagaagtt attaatactg tagtccttac agatgacaag   530280
gtaacaacag aaactataag cgctgcattt aagaacctag agtactacaa agaatacacc   530340
ctatctacaa ctatgattta cgacagaggt aacggtgaag aaactgaaac tctagaaaat   530400
caaaatattc aattagatct taaaaaagtt gagcttaaaa atattaaacg tacagattta   530460
atcaaatacg aaaatggaaa agaaactaat gaatcactga taacaactat tcctgatgat   530520
aagagcaatt attatttaaa aataacttca aataatcaga aaactacatt actagctgtt   530580
aaaaatatag aagaaactac ggttaacgga acacctgtat ataaagttac agcaatcgca   530640
gacaatttag tctctagaac tgctgataat aaatttgaag aagaatacgt tcactatatt   530700
gaaaaaccta aagtccacga agataatgta tattataatt tcaaagaatt agtggaagct   530760
attcaaaacg atccttcaaa agaatatcgt ctgggacaat caatgagcgc tagaaatgtt   530820
gttcctaatg gaaaatcata tatcactaaa gaattcacag gaaaactttt aagttctgaa   530880
ggaaaacaat ttgctattac tgaattggaa catccattat ttaatgtgat aacaaacgca   530940
acgataaata atgtgaattt tgaaaatgta gagatagaac gttctggtca agataatatt   531000
gcatcattag ccaatactat gaaaggttct tcagttatta caaatgtcaa aattacaggc   531060
acactttcag gtcgtaataa tgttgctgga tttgtaaata atatgaatga tggaactcgt   531120
attgaaaatg ttgctttctt tggcaaacta cactctacaa gtggaaatgg ctctcataca   531180
gggggaattg caggtacaaa ctatagagga attgttagaa aagcatatgt tgatgctact   531240
attacaggaa acaaaacacg cgccagcttg ttagttccta aagtagatta tggattaact   531300
ctagaccatc ttattggtac aaaagctctc ctaactgagt cggttgtaaa aggtaaaata   531360
gatgtttcaa atccagtaga agttggagca atagcaagta agacttggcc tgtaggtacg   531420
gtaagtaatt ctgtcagcta tgctaagatt atccgtggag aggagttatt cggctctaac   531480
gacgttgatg attctgatta tgctagtgct catataaaag atttatatgc ggtagaggga   531540
tattcgtcag gtaatagatc atttaggaaa tctaaaacat ttactaaatt aactaaagaa   531600
caagctgatg ctaaagttac tactttcaat attactgctg ataaattaga aagtgatcta   531660
tctcctcttg caaaacttaa tgaagaaaaa gcctattcta gtattcaaga ttataacgct   531720
gaatataacc aagcctataa aaatcttgaa aaattaatac cattctacaa taaagattat   531780
attgtatatc aaggtaataa attaaataaa gaacaccatc taaatactaa agaagttctt   531840
tctgttaccg cgatgaacaa caatgagttt atcacaaacc tagatgaagc taataaaatt   531900
attgttcact atgcggacgg tacaaaagat tactttaact tgtcttctag cagtgaaggt   531960
ttaagtaatg taaaagaata tactataact gacttaggaa ttaaatatac acctaatatc   532020
gttcaaaaag ataacactac tcttgttaat gatataaaat ctattttaga atcagtagag   532080
cttcagtctc aaacgatgta tcagcatcta aatcgattag gtgactatag agttaatgca   532140
atcaaagatt tatatttaga agaaagcttc acagatgtta aagaaaactt aacaaaccta   532200
atcacaaaat tagttcaaaa cgaagaacat caactaaatg attctccagc tgctcgtcaa   532260
atgattcgtg ataaagtcga gaaaaacaaa gcagctttat tactaggttt aacttaccta   532320
aatcgttact atggagttaa atttggtgat gttaatatta aagaattaat gctattcaaa   532380
ccagatttct atggtgaaaa agttagcgta ttagacagat taattgaaat cggttctaaa   532440
gagaacaaca ttaaaggttc acgtacattc gacgcattcg gtcaagtatt ggctaaatat   532500
actaaatcag gtaatttaga tgcattttta aattataata gacaattgtt cacaaatata   532560
gacaatatga acgattggtt tattgatgct acagaagacc atgtctacat cgcagaacgc   532620
gcttctgagg tcgaagaaat taaaaattct aaacatcgtg cattcgataa tttaaaacga   532680
agtcacctta gaaatactat actcccacta ctgaatattg ataaagcaca tctttattta   532740
atttcaaatt ataatgcaat tgcctttggt agtgcagagc gattaggtaa aaaatcatta   532800
gaagatatta aagatatcgt taacaaagct gcagatggtt atagaaacta ttatgatttc   532860
tggtatcgtc tagcgtctga taacgttaaa caacgactac taagagatgc tgttattcct   532920
atttgggaag gttataacgc tcctggtgga tgggttgaaa aatatggccg ctataatacc   532980
gacaaagtat atactcctct tagagaattc tttggtccta tggataagta ttataattat   533040
aatggaacag gagcttatgc tgctatatat cctaactctg atgatattag aactgatgta   533100
aaatatgttc atttagaaat ggttggtgaa tacggtattt cagtttacac acatgaaaca   533160
acacacgtca acgaccgtgc gatttactta ggtggctttg gacaccgtga aggtactgat   533220
gctgaagcat atgctcaggg tatgctacaa actcctgtta ctggtagtgg atttgatgag   533280
tttggttctt taggtattaa tatggtattt aaacgcaaaa atgatgggaa tcagtggtat   533340
attacagatc caaaaactct aaaaacacga gaagatatta atagatatat gaagggttat   533400
aatgacactt taactcttct tgatgaaatt gaggctgaat ctgtgatttc tcaacaaaat   533460
aaagatttaa atagtgcatg gttcaaaaaa atagatagag aataccgtga taacaataaa   533520
ttaaatcaat gggataaaat tcgaaatcta agtcaagaag agaaaaatga attaaatatt   533580
caatctgtta atgatttagt tgatcaacaa ttaatgacta atcgcaatcc aggtaatggt   533640
atctataaac ccgaagcaat tagctataac gatcaatcac cttatgtagg tgttagaatg   533700
atgaccggta tctacggagg taatactagt aaaggtgctc ctggagctgt ttcattcaaa   533760
cataatgctt ttagattatg gggttactac ggatacgaaa atgggttctt aggttatgct   533820
tcaaataaat ataaacaaca atctaaaaca gatggtgagt ctgttctaag tgatgaatat   533880
attatcaaga aaatatctaa caatacattt aatactattg aagaatttaa aaaagcttac   533940
ttcaaagaag ttaaagataa agcaacgaaa ggattaacaa cattcgaagt aaatggttct   534000
tccgtttcat catacgatga tttactgaca ttgtttaaag aagctgttaa aaaagatgcc   534060
gaaactctta aacaagaagc aaacggtaat aaaacagtat ctatgaataa tacagttaaa   534120
ttaaaagaag ctgtttataa gaaacttctt caacaaacaa atagctttaa aacttcaatc   534180
tttaaataat tgaaatctct catctgcttt gcggatgagg gttttcttat tttatgctat   534240
acttaaggta tgcatagaaa aacagtgatt gattttagga ctttggggga gagatatacc   534300
tttacccagc ctattaaaga gttgaaaacg agaaatgtag aagaagtggc agatttgctg   534360
gcacaagtgg aaagctacca agagcaaggt tattatgtgg tggggtatgt cagctacgag   534420
gctgcacctg cttttgagga aaaattagca gttcacaagg atcccctact gggagagtac   534480
ctgctttact ttactgttca tgatatcgta gaaacttccc ctattcctct gacttatgag   534540
gatattgatt tgccctcaaa ttggcaggaa gtaacgtctg cagcagacta tgaaaaggcc   534600
attgcccaaa ttcaccatca tttacggcag ggagatacct atcaggtcaa ctacaccgtc   534660
caacttaagc aaaagttaaa tgccaatcct tttgccatct acaatcgtat ggtggtagag   534720
caggaggcgg gctacaatgc ctatgtggaa catgacgaga tgacagtgat ttccatgagc   534780
ccagagctct tttttgagca aaatgatcgc gagttgacaa cacgaccaat gaaggggacg   534840
actcagcgtg gggtaactga ccaagaagat cttgaacagg ccagttggtt ggaacaggat   534900
cccaaaaatc gctctgaaaa tatgatgatt gtggacctct tgcgcaatga tatgaaccgt   534960
atttctgaag ttgggagcga gcacgtggag cgtctgtgtc aggtagagca gtattcaact   535020
gtttggcaga tgacttcgac catcaagagt cagttgcgag aggatgtgga ccttgttgaa   535080
atcttccgct cactctttcc ttgtggttcc ataacgggtg caccgaaaat tgcgacaatg   535140
gagattatca aggacttgga gcctcaaccg cgtggagtct actgtggaac gattggtctc   535200
ttgcttccaa atggacgacg gatttttaat gtggccattc gtaccattca acttcacaaa   535260
ggtcaagcca tttatggagt tggcggaggg attacttggg atagcacatg ggaatctgaa   535320
taccgagagg ttcatcaaaa ggcagcagtt ctctatcgta aacaagctcg cttccaatta   535380
attacaactg gaaaaatcag ccaaaaacaa ctgatgtttg aagaacaaca tctggaaagg   535440
ctgagaaaag ctagtcgtta ttttgctttt ccttttgatg cagaagactt gggacacaag   535500
attgaggaag agtgtcagga ttgtgaagct aatcgagatt accgcttgcg aatcagcctt   535560
agcaaatctg gagagataga agtcaatcgt caagtattaa cccctctcag tacaagcttt   535620
tgtcaggccc aagtctgtct tcaggaagct gctttgaatc aatcctttac ctactttaaa   535680
accactcacc gaccgcattt gagcctagga gaacaagaga agatttacca caataagtca   535740
ggagaactgc ttgaaacctc tataggaaat ttggttctga aaatcgctgg aaaactctac   535800
acaccgccta tccgacttgg aatcttgcca ggaatttacc gtcagcattt gctagaaaca   535860
ggacaggtag aagagaaagt cttgaccttg gcagatttaa cccaagcaga agctatttac   535920
ggctgtaatg cagtgagagg cttgtatgaa ttaagccttg aggagaacta gatgaaatta   535980
atatttttgc atgggttagg gcagtcagca gagtcttgga aagaagttcg gaatctactg   536040
acagattatc cttctgaggc tatcgagtta tttccttctg gagttagtaa ctatcaacaa   536100
gctaaagagc gagtttatca gcacctagct caagagacag aaccttttgt tttgattgga   536160
ttgtccttag gtgctgccct gacactagaa ctttccagtt acgatttacc aaatcttcga   536220
gctttgattc tgtcaggatg cccgcttaaa ttagcaggga atatcctatt ttatcttcaa   536280
ttgctgattt ttaaactact tcccaaaaga gtatttgaaa aacagggagc agacaagact   536340
cttatggtcg gagtttctga ggagttgaag acacttgatt taacggatat agcaggaact   536400
tacccttatc caaccttact aatttgtggc agcaaagata aaccgaatct tagttctatg   536460
aaagctctcc atagactgtt aacagattcg cagtttcaga tcattcctga tggccctcat   536520
gtcttgaata aggcaaaacc aaaggagttt gtagaaaaga ccagaagttt ccttgaattg   536580
ctgaaataag tttgataaaa taatattgaa atcgatatca taattatggg agaaagaaat   536640
gaataaacgt ctattttcaa aaatgagtct ggtgacgttg ccaattttag ccttgttttc   536700
acaatcagtt ttggcggaag aaaacatcca tttttcgagc tgtaaggaag cttgggcgaa   536760
tggctattcg gatattcacg agggagaacc tggttattct gccaagttag accgtgatca   536820
tgatggtgtg gcttgcgaat tgaaaaatgc tcctaagggt gcttttaaag caaaacagtc   536880
aacggctatt caaatcaaca caagttcagc aacaacaagt ggttgggtta agcaggacgg   536940
cgcttggtac tactttgatg gaaatggaaa tctagtgaaa aatgcatggc agggaagcta   537000
ttacctgaaa gctgatggta aaatggcaca gagtgaatgg atttatgact cttcttatca   537060
agcttggtat tatttgaaat cagatggttc ttatgcaaaa aatgcatggc aaggagctta   537120
ttaccttaaa tcaaacggta aaatggcaca aggtgagtgg gtttatgatt cttcttacca   537180
agcatggtat tacttgaaat cagatggttc atatgctcgc aatgcatggc aaggaaacta   537240
ctatttgaaa tcagatggta aaatggctaa aggtgaatgg gtttatgatg ccacctatca   537300
agcttggtat tatttgacat cagatggttc ttatgcttac agtacatggc aaggaaatta   537360
ctatctaaaa tcggatggta aaatggctgt caatgaatgg gttgatggtg gacgttatta   537420
tgttggcgct gacggagttt ggaaggaagt tcaagcaagt acagcttctt ctagtaatga   537480
tagcaatagt gaatattctg ctgctttagg aaaggcaaaa agttataatt cgttattcca   537540
catgtcaaaa aaacgtatgt atagacaatt aacttctgat tttgataaat tttcaaatga   537600
tgcagctcaa tatgccattg atcatttaga tgattaacag atactggtag gcgaaaaaat   537660
tccttataat tcattcacgc aaacctttgc ataagtgaat ggattttgat atactagtac   537720
tgtaagcatt ttcaattact acacaatgaa aaaggagaat atgatgagtc aaaagattat   537780
tgggattgac cttggtggaa cttctatcaa atttgcaatc ttaacaacag caggagaaat   537840
ccaaggaaaa tggtcaatca agaccaacat tttggatgag ggaagtcata tcgttgatga   537900
tatgattgag tctattcaac atcgtttgga cttgcttgga ttggcagcag cggacttcca   537960
aggcattgga atgggatcac caggtgtggt tgaccgtgac aaagggactg ttatcggtgc   538020
ctacaacttg aactggaaaa cccttcaacc aatcaaacaa aagattgaaa aagctttggg   538080
cattccattt ttcatcgata atgatgccaa cgtagcagct cttggtgagc gctggatggg   538140
tgctggagat aaccaaccag acgttgtctt tataacactc ggtactggtg ttggtggtgg   538200
tattgtcgca gaaggcaaat tgcttcatgg tgttgctggt gcagcaggtg aacttggtca   538260
tatcactgtt gactttgacc aaccaatctc atgtacttgt ggtaaaaaag gctgccttga   538320
gacagttgct tcagcaacag ggattgtcaa cttgactcgt cgctatgccg atgaatacga   538380
aggcgatgca gccttgaaac gcttgattga taacggagaa gaagtaactg ctaagactgt   538440
ctttgatctc gcaaaagaag gagacgacct tgctttgatt gtttaccgta acttctcacg   538500
ttacttggga atcgcttgtg ctaacattgg ttcaatccta aacccatcaa caatcgtcat   538560
cggtggtggt gtgtcagctg cgggagaatt ccttctacaa ggtgttcaaa aagtttacga   538620
tgaaaatagt ttcccacaag tacgcacatc tactaaatta gctcttgcaa ctctaggaaa   538680
tgacgctgga gttatcggag cagcatcact tgtattgcaa taagataatg agagaggaaa   538740
atgctaacct agagttagta atgttcctct tttatttttt atgctatact agttaggaca   538800
atgaatgagg tgaaacgaaa tgacaaaagc agatacgatt tttaaagaga atattgaacg   538860
cattctaaag gaaggtgttt tctcagagca ggctcgtcct aagtacaagg atgggactgt   538920
tgctaattcc aagtatgtaa ctggtgcctt ttccgagtac gacttatcta aaggagaatt   538980
tcctatcaca accttgcgtc ccattgcaat caaatccgcc atcaaagaag ttctctggat   539040
ttaccaagac cagtcaaata gcttagaagt gcttaatgac aagtacaatg ttcactactg   539100
gaatgactgg gaagttggag acacgggaac cattggtgag cgctatggtg ccgttgttaa   539160
gaaacacgac attatcaata agcttctcaa acagttggaa accaatcctt ggaaccgccg   539220
caatattatt tcgctctggg attaccaagc tttcgaagaa acagatgggc tgctcccgtg   539280
cgcctttcag accatgtttg atgttcggcg tgttgatggg gaaatctatc tggatgcgac   539340
cttgacccag cgctccaatg atatgctggt ggcccaccac atcaacgcta tgcagtatgt   539400
ggctttgcag atgatgattg ccaaacattt tggctggaag gttgggaagt tcttctactt   539460
catcaacaac ctccatatct atgataatca atttgaacaa gctcaggaat tgctccgtcg   539520
ggagccgtca aactgccaac cacgcttggt tttaaatgtt cctgatggga ctaatttctt   539580
tgatatcaaa gcagaagatt ttgagttggt ggattatgac cctgttaagc cacagttgaa   539640
gtttgaccta gctatttaaa agaatagaaa aaagaagttg agaataatcc caacttcttt   539700
tgtttcttaa cgtgatacgc ggcgacgagc tgctttttta cggttttctt cgatgaaagc   539760
tgctttttgc tcttctggtt cgattacttt ctttttaaat gcgtatactg cacctgcaac   539820
ggcagcgaca gttcctgcga cacctgttac aagaccttta gcgaatcctt tagccatgag   539880
tcttcctcct ttatattctc aatcagccag cctcctcaag aggtcacatt tttctgactg   539940
acctttttgt gttataataa tagtaacgaa aaaatgggaa tttttcaagg aaaaaagatg   540000
aaaacaaaaa taattgtgat tgttggaccg actgctgttg gaaagacggc tctagctatt   540060
gaagttgcaa agcgttttaa tggcgaagtg gttagtggag atagccagca agtctatcga   540120
ggacttgata ttgggacggc caaggctagt ccagaagagc aggcagctgt tcctcatcat   540180
ttaatcgatg ttagagagat aaccgagtct tactcggctt ttgattttgt ttcagaagct   540240
aagatgacta ttgagggtat tcacaaccgt ggcaagctag ccattatcgc cggtgggact   540300
ggactttata tccagagctt gctagaaggt taccacctag gtggggagac tcctcatgag   540360
gagattttag cttatcgagc tagtttggag ccatattcag atgaggaatt agcccatttg   540420
gtggatcaag caggccttga gattccccag tttaatcgtc gtcgtgctat gcgtgcctta   540480
gaaattgccc attttggtca ggatttggaa aatcaagaga ccttgtatga accgctgatt   540540
atctgcttgg atgatgaacg tagtcaactt tatgagcgta tcaaccaccg agtggatttg   540600
atgtttgagg ctgggctttt ggatgaggcc aagtggctgt ttgaccattc ccctaatgta   540660
caggctgcta aaggaattgg ctataaggaa ctctttcctt atttccgtgg agagcagacc   540720
ttggaggaag ctagtgagag tcttaaacag gcgactcgtc gttttgccaa gcgtcagctg   540780
acctggttcc gtaatcgcat gcaggtcacc ttttatcaga ttggagaatc tggtgtacaa   540840
gaccgcattt taagccagat agaggagttt ttagatgatt gaaacggaga aaaaagagga   540900
gcgagtcctg ctgattggtg tggaattgca gggtatggac agttttgacc tctccatgga   540960
agaattggct agtttagcga aaacggcagg ggcagtcgtt gtagatagct acagacaaaa   541020
acgtgaaaaa tatgattcca agaccttcgt cggctctggt aagttggaag agattgcgct   541080
tatggtggat gcagaagaaa tcactactgt catcgtcaac aatcgtctga ccccaaggca   541140
gaatgtcaat ctagaggaag ttctcggtgt taaggtcatt gaccgtatgc agttgatttt   541200
ggatatcttt gccatgcggg ctcgaagcca tgaagggaag ctccaagtcc acctagccca   541260
actcaaatac cttttgcctc gcttggttgg tcaggggatt atgctcagcc gtcaggcagg   541320
gggaattggt tcccgtggtc ctggtgaaag ccagctggag ctgaaccgtc gtagcgttcg   541380
caatcaaatc acggatatcg agcgccagct caaggtggtt gagaaaaatc gtgcgactgt   541440
cagagaaaaa cgtttggagt ctagcacttt taagattggt ttgattggtt atactaatgc   541500
tgggaaatca actatcatga acatcttgac cagtaagacc cagtatgaag cagatgagct   541560
ctttgcgact ctggatgcga caaccaagag tattcatctg ggaggcaatc tccaagtaac   541620
tttgacagat accgttggct ttatccaaga tttgccgaca gagttggtgt ccagtttcaa   541680
gtcaaccttg gaagaaagca agcatgtgga ccttctggtt catgttatcg atgctagcaa   541740
tccttaccac gaggagcatg aaaaaacggt tctctccatc atgaaagacc tggacatgga   541800
agatattcct cacttgacgc tttataataa agcggatttg gtggaggatt tcacgcctac   541860
ccaaacgcca tataccctca tttctgccaa gtctgaggac agtcgtgaaa acttgcaagc   541920
attattgcta gataagatta aggaaatttt tgaagcattt accctgcgag tgcctttttc   541980
aaagtcctac aagattcatg atttagagag tgttgcaatt ctggaagaac gtgattatca   542040
ggaagacggc gaagtgatta caggctacat ttccgagaaa aataaatgga ggttagaaga   542100
attttatgac tgatattaaa actttggctc taaagtatgg aggttataca agtctggaca   542160
aggtctatct ggatcagctt ctagctggta aaacagatca ggagcagtta acacttatta   542220
cacctccgcc aagtgttgtt aatgcctact ttgcagaact ctatcagaaa aagagtcctc   542280
aggctgcgac ggattatttt gcagaactca gtcaggaact gaatctttac aatactgagc   542340
caagtttcac cctagaaaat aagcctttta ttcggcttaa tctgtctggt aaatcctttg   542400
gtttttgtta tgagagtgac ggccttggtc ggattttctt tgaaaatgag gagaaaatct   542460
cggatgactt gctctttgaa attgcgcaaa ttttccccca tcaattagtc tttgaagagt   542520
ctggtaagat ttacatgaag cctgtcgagg acgaggaagt tatcagccta gaaagtctca   542580
cagctttgac tgatttggaa agattggctg atggtcgaaa acgtctcaaa ggctacagcc   542640
aagaggattt attgcaagaa gctgctgctt tttctggcaa acgctatttc cgatcggaaa   542700
accgcacagc catgttatat attgattaat tagaaagtat cgaatggata ttcaattttt   542760
aggaacgggg gctggtcagc cctctaaagc ccgcaacgtt tcaagtctcg ccctgaaact   542820
tttggatgag attaacgaag tttggctctt tgactgtgga gaaggtacgc aaaatcgcat   542880
tctggaaacc acaattcgac cacgtaaggt cagcaaaatc tttattaccc atctgcatgg   542940
agaccacatt tttggtttgc caggtttcct ttctagccgt gcctttcagg ccaatgaaga   543000
gcagacagat ttggaaatct acggacctca aggaatcaag tcatttgtct taaccagcct   543060
tcgtgtgtca ggttctcgtc tgccctaccg cattcatttc catgagtttg accaagattc   543120
tctgggtaaa attcttgaaa ccgataaatt cactgtgtat gcagaggagc tggaccacac   543180
tattttctgt gttggctatc gtgtcatgca aaaggatcta gaagggacgc tggatgctga   543240
aaaactcaag gctgctggtg ttccgttcgg cccgcttttt ggtaaaatca aaaacggcca   543300
ggatcttgtt ttggaagacg gaactgaaat caaggcagca gactatatct cagcgccacg   543360
tccaggtaag attatcacta ttttaggaga cactcgaaaa acgggtgcca gtgtgcgtct   543420
ggctgtcaat gcagatgtcc tagttcatga gtccacttat ggcaagggtg atgaaaaaat   543480
tgctcgtaac catggtcact caactaatat gcaagctgca caagtagcgg tagaagcagg   543540
tgccaaacgc ctcctactca accatatcag tgcccgtttc ctctcaaaag atattagcaa   543600
actcaagaaa gacgctgcca caatttttga aaatgtccat gtggtcaaag acttggaaga   543660
agtggaaatc tagcagtcac agaaaggata agtatgccta ctattctcat taccggagct   543720
agcggtggtc tagctcaaga aatggtcaaa ctcctgccca atgaccaact catcttgctt   543780
ggtagaaata aggaaaaatt agcccaactc tacggaaatt attcccatgc agaattgatt   543840
gaaattgata ttaccgacga ttcagcccta gaagctctgg taactgatct ttatctccgc   543900
tatggcaaga ttgatgtctt gattaacaac gctggttacg ggatttttga gggatttgac   543960
cagattgctg ataaagatat tcaccagatg tttgaggtca atacctttgc cctgatgaat   544020
ctgtctcgtc accttgcggc tcgtatgaag gaaagcagca aagggcatat catcaacatc   544080
gtcagcatgg caggtctaat agctactggc aagtctagtc tttactcagc gaccaagttt   544140
gcggctattg gtttttcaaa tgctctgcga ctcgaactta tgccctatgg agtctatgtg   544200
acaacagtca atccaggacc aatccgtaca ggatttttcg accaagccga cccagatgga   544260
acttatctta aatcggttga tcgcttcctg ctagaaccag atgcagtggc taaaaagatt   544320
gtcaagatta taggaaaaaa caaacgagaa ctcaatctcc cgattttgtt gaacctagcc   544380
cataagtttt atactctctt tcccaagcta gctgataagt tggcagggga aacttttaat   544440
tataagtaaa aagaaccaat gtgcaggttg ttgctagcct acatattggt tcttatcatt   544500
tctcaactat caaactgaac ttcttctagg agatagtcta taaagcgttc gcccatctta   544560
gataggctgg ttttctcatg ctggatatag accagctcga tcgggtcatc aatatccagt   544620
gggatagaaa cgatattgtc tccgtttagg ttgctgttca aaatccctgt cgcaatggta   544680
taaccatcca aaccaatcaa gagattaaag agggtggcac ggtcactgac cacaatggat   544740
ttcttgtggt gttcttgaga aagaatctct tctgaaaagt agaaggagtt gtgcgtccct   544800
tggtcatagc tgaggtaagg gaaattctcc aaatcagaca gtttcacctt gtctttcttt   544860
gccagagggt tggtcttgct gacaaagata tgcggttgcg ctgtgaagag atggtgggct   544920
agcaggtgat tgtcatccag catcttggtt aaaacatcac ggttgtaact gtttaagaag   544980
aggaccccga cctcactgcg gaagttcttg acgtcgtcga taatctccca agtccgagtt   545040
tcacgaagga agagttcgta tttctccata tcgcttttct tgagcaaaga gacaaaggca   545100
ttgaccacaa aggcatagtg ttgagacgaa acgctaaaga gttcgcggtg ggcgacagga   545160
tttttatagc gttcctccag aagctgggtc tgctcgacaa cctgacgggc ataagagaga   545220
aactccatgc catcacgggt caaggtgatt cccttgggat tgcggataaa gatctcaatg   545280
cccatttcat tttccaaatc tcgcactgca ttggagagac ttggctgagt gataaagagt   545340
tgcttggctg cctcattcat ggagccagtt tcgacgattt tgataatata atgtaattgt   545400
tgaattctca tgtttttatt gtaccatact tgccttagaa tcgctaaaga agataggaaa   545460
ataaggagca ttgtgtgagt ctcttcttga aaaaaacaca aaattttgct agaatgagtc   545520
ttatgaaaac attctatgat gtgcagcaat tcctcaaacg atttggtatt attgtttaca   545580
tgggaaaacg cttatatgat attgaactga tgaagttgga actatctcgg atttacgatg   545640
cagggttgat ggataaatta gactatctag aggcagaagc agttcttcgc agagagcaca   545700
aggtagaatt ggattatatt gagaaaaatg gagaaaagaa ctaatggtta cttggatttt   545760
gtgggcactt atactagcaa tgttggcgtg gatgggcttt aactatcttc gtattcgccg   545820
tgcggctaaa attgtggaca atgaggagtt tgaagccttg attcgtacgg gtcaattgat   545880
tgatttgcgc gacccagcag aattccacag aaaacatatc cttggtgcac gcaatattcc   545940
ttcaagtcag ttgaaaacta gtcttgcagc ccttcgtaaa gataaacctg tccttctcta   546000
cgaaaaccaa cgtgcgcaac gagttacaaa tgcagctctt tacttgaaaa aacaaggttt   546060
ttctgagatt tatatccttt cttatggctt ggattcttgg aaagggaaag tgaagactag   546120
ctaaccttat ttccaaatta gtcgaatgat aggatgaagc tattgtttta tagtataatt   546180
aatttgtata aaatttaagg agttcttaga acataaaaga aaagaagaaa aatccacttt   546240
ttgtgggtat cttgtcgatt attcttggtt tgttatttcc aattgtaggc ctgattttgg   546300
gtatcatagg attggtcttg gctatttcat accaaaaaga gtcacaatta gactataaaa   546360
tagaaaagat tcttaatatc ttaggaattg tgatttctgt agttaactgg attgtagcaa   546420
tcgccttaat ttttcggtaa ataaaagaaa aaagctttag ttttaaagct ttttttgttt   546480
tatcgactca tctctaaata gtttttaatg atttgtaact ctttttggtt caaagggcgg   546540
tagttacctt ctgctaaatc tgggttcaat gtgaagtccc caaattggat tcttttgagg   546600
ctagtcacct taacaccaac cgagaggaac attttcttga tttgatgaaa ttttccttct   546660
gaaatggtga tagaggcttg actgagggag ggacttgcag atagaatctc tagttttgcg   546720
ggtttacaga cagtgtcatc taaaaagaca attccttttt gaaaggtttg gatatggtca   546780
ggtgttagaa gtccattaac ctcaacttgg taagtcttat cgacatgata ttggggatgg   546840
aggagctgaa agcccaaggg accgttatcg gtcaagagga ggagtcccgt tgtatctcgg   546900
tccagtcggc caacggcata gagcttgtca gactggatgt tagatggaag caggtccatg   546960
acggtcggaa gttccttgtc tttgttggct gtaacggcac cagcaggttt atgaagcata   547020
agataggtgt gttcatagcc ttgaatgatt cgatcctgaa aaaggagttc ttgtagtcct   547080
gtatcgatat tttgagctag ggagcgggct gggcaaccat cgactagaat ttcccctctg   547140
aggagtgctt gcttcatggc ctttcggctg attttttctt gagctaataa attatctaaa   547200
cgcatactgt gcctatctta tcataagtcg ctcgctttga aaaggcttga cgtgaaaaga   547260
aaagcagagt gaaaacattt acacttgctt gagttatgtt atttatttga aattatggta   547320
taatcgttca gttagaaaat aaattttgaa tattatagag gaaatcatga caaaattaag   547380
agaagatatc cgtaacattg cgattatcgc ccacgttgac cacggtaaaa caaccctggt   547440
tgacgaatta ttgaaacaat cagaaacgct tgatgcacgg actgaattgg cagagcgtgc   547500
tatggactca aacgatatcg aaaaagagcg tggaattacc atccttgcta aaaatactgc   547560
cgttgcttac aacggaactc gtatcaacat tatggacaca ccaggacacg cggactttgg   547620
tggagaagtt gagcgtatca tgaaaatggt tgacggtgtt gtcttggtcg tagatgccta   547680
tgaaggaacc atgccacaaa ctcgtttcgt attgaaaaaa gccttggaac aagaccttgt   547740
cccaatcgtg gttgttaaca aaatcgataa gccatcagct cgtccagcag aagtagtgga   547800
tgaagtcttg gaacttttca tcgagcttgg tgcagatgac gaccagcttg atttcccagt   547860
ggtttatgct tcagcgatca acggaacttc ttcattgtca gatgatccag ctgaccaaga   547920
agcgactatg gcaccaatct ttgacacgat tatcgaccat atcccagctc cagtagataa   547980
ctcagatgag cctttgcagt tccaagtgtc acttttggac tacaatgact tcgttggacg   548040
tatcggtatc ggtcgtgtct tccgtggtac agttaaggtt ggggaccaag ttaccctttc   548100
taaacttgac ggtacaacta aaaacttccg tgttacaaaa ctcttcggtt tctttggttt   548160
ggaacgtcgt gaaatccaag aagccaaagc gggtgacttg attgccgttt caggtatgga   548220
agacatcttt gtcggtgaaa ccatcactcc gacagatgca gtagaagctc ttccaatcct   548280
acacatcgat gagccaactc ttcaaatgac tttcttggtc aacaactcac catttgctgg   548340
taaagaaggt aaatgggtaa cttctcgtaa ggtggaagaa cgcttgcagg cagaattgca   548400
aacagacgtt tcccttcgtg ttgacccaac tgattcacca gataaatgga ctgtttcagg   548460
acgtggagaa ttgcacttgt caatccttat cgaaacaatg cgtcgtgagg gctatgaact   548520
tcaagtatct cgtccagaag ttatcgtaaa agaaatcgac ggtattaaat gtgaaccatt   548580
tgaacgtgta caaatcgaca ctccagaaga ataccaaggg tctgttatcc aaagcctttc   548640
tgaacgtaaa ggtgaaatgt tggatatgat ttcaactggt aatggtcaaa ctcgtttggt   548700
cttccttgtt ccagcgcgtg gtttgattgg atactcaact gagttcttat caatgactcg   548760
tggttacggt atcatgaacc ataccttcga ccaatacttg ccattgattc caggggaaat   548820
tggtggacgt caccgtggtg cccttgtttc tatcgatgct ggtaaggcta caacttactc   548880
aatcatgtct atcgaagaac gtggtacgat ctttgtcaac ccaggtactg aggtttatga   548940
aggaatgatc atcggtgaaa actctcgtga aaatgacttg acagttaaca tcacgaaggc   549000
aaaacaaatg accaacgttc gttcagctac taaggaccaa acagctgtta tcaagacgcc   549060
tcgtatcttg acacttgaag agtctcttga gttcttgaac gacgatgagt acatggaagt   549120
aacgcctgag tctatccgtt tgcgtaaaca aatccttaac aaagcagagc gtgagaaagc   549180
taacaagaag aaaaaatcag ctgaataaga gctagaaaga gagaaagatg gtctatttag   549240
tcctaggaat tttactgctc ctactctatg tatttgcgac accagaaagc attaaaggga   549300
ctgtcaatat cgtcgctatg gtatgtattt tagtggcact cttgatttta ttggttctat   549360
cttttctgaa aatttttcaa ttaccaacag aaatattcct agcaatagcc atgttgatcc   549420
tagcttactt tagtgttaga gacatcacac tcatgccagt caaaaaaagt aaaagaagat   549480
aaaaaagaga gtttcggctc tctttttgct aggaatttta caatagtttg aattgctttt   549540
tagttaacac catctctttt acttgtatag tatgaatggg aaaaacttga ataaaattcg   549600
ttaatggcat ctattttata tttggttagt actggttgca tattattttg aaataaaact   549660
actatataat attattcaca gaggtaatat agtaaaatat ctaaaaaatt cgattttttc   549720
cttgacaaca aataataaaa aagttattct tatcacataa gaaagcggtt tcaataaaag   549780
agagaggagg atttattttg ttgcattgtt gctcaaggtg tgcttttttt gaaagaaaaa   549840
ataaaatgaa aacgaaaaaa catagattac ttgctctagc tcttatttca agttttacat   549900
tattgggagc tgcatcagct gctgtataat atccagatgg aggagtatgg acatatggag   549960
aaggttcagg aggtggttag gctttttcaa attactatca tggtaaaaaa tatcattatt   550020
catctatcgt gagcagatgg gatggtcatt ctgataaagg agaagctcct gctggaaaac   550080
ctcctatgca tggatttgga ctaaatgggg agaacaagta gcattttact gtgattatga   550140
ctaatcgttc attgatttaa atcgttcccc ttgtaagaaa ttacaggggg aattttgttt   550200
acaaggagtc tactatgaag aaactattca tattattatc aacttttttt ctcagcttct   550260
tccttgcttg gattattgtc ttacgtgcgc cacaatattt atatgcaagc tatgattccg   550320
tttctttact tcgtgtcaaa aaagatactc aggaaccgac gcgtgaggta tttgaacagg   550380
aattggagaa ttttgcaaac tcagaacaga gtttaatagc tagaagaatt gtagagccga   550440
gtaaggatgg gacgactcac tttacttatg caacttatgg tcagggaact ttaccaaaag   550500
aattccaaga agctagccaa gaaagtcgtg aacgtagtga tccgctaaat agttatctcc   550560
ttttgtcagg ctccttgacg aaagaaaagc ttgccgataa attaggagat ttgggttata   550620
aagcaagtgc tgaccgaaag ataccgccct attttcttgc ttttcgaata ttactaaatc   550680
cccttatttt aattagttta gcaatatttg gcttatcttt ctttgcttta gtgattatca   550740
ctcggattaa ggaaatgaga gcagcaggta taaaactctt ttctggtcag actctcttat   550800
ccatcatggg gcattcttta tctactgata tcaaatggct ccttctatca gccctccttt   550860
ccttcctagg tgggggagtc gttcttttta gtcaaggttt gttttatcct atcttgttag   550920
ccacctatgg ttttgggatt agtttctatc tgttgttttt attggcgatt tcaattttac   550980
taatgctcct ttacctaatg agtttgagtt acaaagcatt agttcccgtt attaagggaa   551040
gattacccct taaacgcttg atggctttaa ccctattgtg tcagttagta gctgttttta   551100
cagtaggcta cgctgttaag acaggtttga cgtcttacca acgattgaaa gaacttgaaa   551160
tttcaaaaca agcatggcag gacagagcag actattacca gatttccttt ggcttaggtg   551220
atagaggaaa agatacagaa aatcagagca agtggtatgc ctttgccaag gaagcaatcg   551280
aagaagaaca agctctttat gtaaaggata atctgctcca ttttgccaat ccacaaggaa   551340
aaaatgaaca gggagagaca ctggatacct atagttcaga tgctaatacg ctctatgtta   551400
gtcccagtta tttggacaag gaaaaggtcg tggtagatgc tgagaccaaa cagaagttag   551460
cccatctcca aaaaggtgag tttatcctct tgctcccaga acatttgcgc tctcgagaag   551520
cagaacttaa gaaagttttt gaagaaagat tgagttatta tggaaaatct ggtgaggagg   551580
caagtgctcc tttggattat gagatgaaag cgcacgttag ttatctttca atgggagaaa   551640
agcggtttgt ttataataac ggtgagaatc ccgtatctac tcagtatttg actgatccga   551700
ttttagtggt attcacgccg acttctacag gtgatagttt tatatcctta tctagttggt   551760
ctatcaatgc tggaaaacaa ctctttatca aaggatatga gagtgggcta gaactcttga   551820
agaaagctgg aatttatgag caagtatcct atcttaaaga aggaagaagt gtttatctaa   551880
ctcgttataa tgaagttcaa actgaaacag caactttaat cttaggagct attgttggaa   551940
tagccagttc cttgttactc ttttattctg tcaatcttct atatttcgag caattccgcc   552000
gagatatctt gattaaacga atttcaggtt tacgattttt tgaaacacat gctcagtata   552060
tggttagcca atttgctagt tttgtatttg gtgctagtct ctttatttta agcagtcgag   552120
acttggtgat tggcttgctc actttattgg tctttctagc tagtgcagtt ttgacgcttt   552180
accgtcaagc gcagaaagaa tctcgtgttt ctatgacaat tatgaaagga aaataggatg   552240
attgaactaa agaatatatc taaaaaattt ggaagccgtc agctattttc agatatgaat   552300
cttcattttg aaggtgggaa aatttatgcc ttaatcggta caagtggctg tggtaagaca   552360
acactcttga atatgattgg acgattggag ccatatgaca aagggcaaat catctatgat   552420
ggcacttctc ttaaggacat caagccttct gttttcttta gagattactt aggatactta   552480
tttcaagatt ttggcttaat tgaaagccaa accgtcaaag agaatctcaa tctgggttta   552540
gttggtaaaa agttgaagga aaaagagaaa atctctttga tgaaacaagc tctaaaccgt   552600
gtaaacctct cttatttgga tttgaagcaa cctatatttg agttatcagg aggagaagca   552660
caacgtgttg cactagcgaa gataatttta aaggatccac ctttgatcct cgcagatgaa   552720
ccaaccgctt ccttagaccc caaaaactct gaggaattac tttccatcct agaatcttta   552780
aaaaatccga atcggaccat tattattgcg acccataatc ctctgatttg ggagcaagtg   552840
gatcaggtca ttcgagttac cgatttatca catagatgat atggtaagat tcagttagaa   552900
gaaagagtca caaacacact ttgtggcttt tttatttcca taaaaatggt aaaatagtag   552960
gagtagaaat ggagttcgag acatgaaagt aatagatcaa tttaaaaata agaaagtcct   553020
tgttttaggt ttggccaagt ctggtgaatc tgcagctcgt ttgttggaca agctaggtgc   553080
cattgtgaca gtaaatgatg ggaaaccttt cgaggacaat ccagctgccc aaagtttgct   553140
ggaagaaggg atcaaggtca ttacaggtgg ccatcctttg gaactcttgg atgaagagtt   553200
tgcccttatg gtgaaaaatc caggtatccc ctacaacaat cccatgattg aaaaggcttt   553260
ggccaaggga attccagtct tgactgaggt ggaattggct tatttgattt cagaagcacc   553320
gattattggt atcacaggat cgaacggtaa gacaaccaca acgactatga ttggggaagt   553380
tttgactgct gctggccaac atggtctttt atcagggaat atcggctatc cagctagtca   553440
ggttgctcaa atagcatcag ataaggacac gcttgttatg gaactttctt ctttccaact   553500
catgggtgtt caagaattcc atccagagat tgcggttatt accaacctca tgccaactca   553560
tatcgactac catgggtcat tttcggaata tgtagcagcc aagtggaata tccagaacaa   553620
gatgacagca gctgatttcc ttgtcttgaa ctttaatcaa gacttggcaa aagacttgac   553680
ttccaagaca gaagccactg ttgtaccatt ttcaacactt gaaaaggttg atggagctta   553740
tctggaagat ggtcaactct acttccgtgg tgaagtagtc atggcagcga atgaaatcgg   553800
tgttccaggt agccacaatg tggaaaatgc ccttgcgact attgctgtag ccaagcttcg   553860
tgatgtggac aatcaaacca tcaaggaaac tctttcagcc ttcggtggtg tcaaacaccg   553920
tctccagttt gtggatgaca tcaagggtgt taaattctat aacgacagta aatcaactaa   553980
tatcttggct actcaaaaag ccttgtcagg atttgacaac agcaaggtcg tcttgattgc   554040
aggtggtttg gaccgtggca atgagtttga cgaattggtg ccagacatta ctggactcaa   554100
gaagatggtc atcctgggtc aatctgcaga acgtgtcaaa cgggcagcag acaaggctgg   554160
tgtcgcttat gtggaggcga cagatattgc agatgcgacc cgcaaggcct atgagcttgc   554220
gactcaagga gatgtggttc ttcttagtcc tgccaatgct agctgggata tgtatgctaa   554280
ctttgaagta cgtggcgacc tctttatcga cacagtagcg gagttaaaag aataatatga   554340
aaaaaattgt ctttacaggt ggggggacgg ttggacacgt taccctcaat cttttgttaa   554400
tgcccaagtt catcgaagat ggttgggaag tccactatat cggggacaag tgtggtatcg   554460
aacaccaaga aatccttaag tcaggtttgg atgtcacctt ccattctatt gcgactggaa   554520
aattgcgtcg ctatttctct tggcaaaata tgctggacgt cttcaaagtt ggttggggaa   554580
ttgtccaatc gctctttatc atgttgcgac tgcgtccaca gacccttttt tcaaaggggg   554640
gctttgtctc agtaccgcct gttatcgctg cgcgtgtgtc aggagtgcct gtctttattc   554700
acgaatctga cctgtctatg ggcttggcca ataaaatcgc ctataaattt gcgactaaga   554760
tgtattcaac ctttgaacaa gcttcgagtt tggctaaggt tgagcatgtg ggagcggtga   554820
ccaaggtttc ggacaaaaac actccagaac cagatgaatt ggtggatatt caaacccact   554880
ttaatcccaa attgccaact gtattgtttg ttggcggttc tgcaggcgct cgtgtcttta   554940
accaattggt gacagaccat aagaaagaac taacagagcg ctacaatatt atcaatctaa   555000
ctggagattc tagtctgaat gagttgaggc aaaatctttt tcgtgttgac tatgtgaccg   555060
atctctatca acccttgatg gaattggctg atattgttgt gacacgaggt ggtgccaata   555120
cgatttttga gctcttggcg atagcaaaat tgcatgtcat tgtgccgctt ggtcgtgaag   555180
ctagtcgtgg tgaccagatt gaaaatgcag cttactttgt taagaaaggc tatgcagaag   555240
accttcaaga aagcgatttg accttggata gtttggaaga gaagctttct cacttactaa   555300
gtcacaagga agattaccaa gctaagatga aagcttctaa ggaattgaaa tctctagcag   555360
atttttatca attgttgaaa aaagatttat cataaggaaa gtaaatgtca aaagataaga   555420
aaaatgagga caaagaaacc ctcgaagaat tgaaagagtt atcagaatgg cagaaacgaa   555480
accaagaata tctaaaaaag aaggctgaag aagaggcggc tctagctgag gagaaggaaa   555540
aggaaagaca agctcgaatg ggagaagaat ctgagaagtc agaggataaa caggaccagg   555600
agagtgaaac agaccaggaa gattcagaat cagctaagga agagtctgaa gaaaaagtag   555660
catcctcaga ggctgacaaa gagaaagaag agaaagaaga accagagtct aaagagaagg   555720
aggaacagga taaaaagctt gctaaaaagg ctacaaagga aaaaccagcc aaagcaaaga   555780
ttcctggtat ccatatcttg cgagccttca cgattttatt tccaagtctg cttctattgt   555840
ttgtctctgc ctacttgctc agtccttatg cgaccatgaa agatattcgt gttgagggaa   555900
cggtgcaaac tacagctgat gatattcgac aggcttcagg cattcaggat tcggattata   555960
cgattaacct tctgctagac aaggcaaaat atgaaaagca gattaagtct aactattggg   556020
ttgaatcagc tcaacttgtc tatcaatttc caactaagtt cactattaag gtcaaggaat   556080
atgatattgt ggcctactat atttctggtg aaaatcatta tcctattctt tccagtggtc   556140
agcttgagac tagttctgtg agtctgaaca gtttaccaga aacttattta tcagttctct   556200
ttaatgatag tgaacaaatc aaagtttttg tctcagaact tgctcaaatt agcccagaac   556260
tcaaggcggc tatccaaaag gtggaattag ccccaagcaa ggtgacatcc gatttaattc   556320
gattgaccat gaatgattcg gacgaagtct tggttcctct atctgaaatg agtaagaaac   556380
tgccatatta cagtaagatt aagcctcaat tgtcagaacc gagtgtggtc gacatggaag   556440
ctggaatcta cagctacact gtggcggata aattaattat ggaagctgag gaaaaagcca   556500
aacaagaggc caaggaagct gagaaaaaac aagaagaaga acagaaaaaa caagaggaag   556560
agagcaatcg aaaccaaacg acccagcgtt catcgcgtcg ctaggtttac cttttctctt   556620
atagttcttt agtgaccatg tttttacgtt taatatttga catctgtttt tctttatgtt   556680
acatctgcaa tgtaatcgat tacaaaataa tttttgatga agaaggtaac acatatgtca   556740
gatgaagtat tcttatttga agaaattgaa gaaatcgtag cccctacaga tggtgaattt   556800
ttgggggaag ttttacttgg aactggggta gttctcttaa ttggagtagc ctgttgttaa   556860
aaagataggg agtgataatc atgcaagata actttttatt tgaggaaatt gaagaaattt   556920
cagtaccagt taatgatttt tcagctggac ttgcaacagg tatcggattt ggtttagcaa   556980
tccttgctct tgctggttgt tgaagtttgt tcatttacta acatcaagct ttttcaattt   557040
cattttagac agtcatttaa attttccgta ttagtcttgc agcaagagat taatagaatt   557100
agtcattatt ttattgattg cggactgagg gactagagta tgttttactt aacccctctt   557160
ttatttatta aaggttaggt ttgttatgag aattgttgat aagattaaga tattacctac   557220
tccttatgag ggacactatc atttatatat accatccagt aagaaacatg tattagttgg   557280
gaaacaggaa aaaaatggtt agagcaacta ataggtcaag aatttaccat atcggactta   557340
ttagtgttag tagggaagaa atatttttaa aatatcttgg gactttaata taacattatc   557400
tgaaaaatta aactataaaa gatttaataa gaattttgaa aaaatcctat cttgttgtca   557460
ttatatttgc aacgatacat gaaattagtc atgcaataat tgctaataat tatcaaattg   557520
agatcccaaa ttgtggaata atgctacttt tgtttaattt ggcttttttt gtagatttaa   557580
gtggggtgca attcctaaaa aataaaaaac aatttttgaa aattatgtta gcaggaattg   557640
cttcaaattc gattttatca cttacaggtt tacttgtttt attgttcaca tcgtataaat   557700
tgcttggact cttatttttt atcattaact taggtatgat ttttattaat tcaattcctt   557760
tttttcagta tgatagtggt attattttaa gatacttgaa ttctaacaat aataacttga   557820
attttcaata tatagttcaa cttttaatag catttgttat tatttatttt cctttgagtc   557880
aactattaca gtttttgaca cccaatatta ttgttcgtag tataggaggg gtggttgttt   557940
ctatactgct ttctatatta tatatgatag gaaggacgaa atatgttcta cgtaaatagt   558000
tatgtttttg cttataaaaa agaaggtata atgtatttac gtggtcggag tatgcgggaa   558060
atagctatag aacctcaaat ttcgcaagaa tttatcaacg atctatttaa tagttgtaag   558120
gaactattag agatagaaga agtattaggc agtaaactaa catttgaact ataaatgaac   558180
aaattttaat ttcggatgag atagatattg atagtagata ttctagaact aaaggttact   558240
attcgttatt ttataatgaa gagtataata aaatacagaa taaaacagta ttagtattag   558300
gagcaggagt cttaggatgt tatatatctc taagtctaag tatgtatgga gtgaggaaac   558360
ttattgtcgc tgattacgat ataatagaac catcaaattt aaataggcaa attctttata   558420
cagagtcgga tgttggtaag gagaagatta atgttctttc tgaaaaaata cacaagtata   558480
attcagatgt tcaggtagta cctatttcta ttaaagtttc ttcagtagaa gaattagaaa   558540
aaattgttgc ggaatatggg agtatagatt ttatcgttaa agcaattgat acgcccattg   558600
atattataaa aattgtcaat caatttgctg tatcgcataa gatatcctac atatcaggag   558660
ggtttaatgg atgctatctt attattgata atatatatat ccctaccatc ggttcttgct   558720
ttggttgtcg gaatataaac aaagatataa ataagtacac tttatctgat aagacaaagt   558780
ggccgactac accagagatg cctgctattt tgggagggat aatgactaat ttaataatta   558840
aaatatttct gggatgttat aatgaaatcc taatagataa cgcttacgtt tataatatga   558900
gaaatcatgc tctaagtcaa gaaaaatatg ttctggaaaa cggagaatgt ccaatttgta   558960
aaaaaataat aaagtgaaag ataacaatat tagagcgaaa acatttattc gttcagtttg   559020
tttttgctta ttatcaggag gagtagcttt tttatctgct attgggcagt tcactgttat   559080
agaaacacaa ttaatagtat tgttcttggg tattattttt gctatatatt atgcttacta   559140
caataaaaat attcaaacat cattggaaaa tatagtatgg cttttttcat cgtttgagat   559200
tttatttttg cttgttaatt ttagaacatt tattcagtta ccagtggata tttttattgg   559260
tatgataata tttttaatgc tgtggatatt tattatgtta ggtatagtgt gtcttagtta   559320
ttatataact ttattattta gcaaggaggc ttagtatgtt taaaaaaata ggtataatga   559380
gcatttgcat atatataatt attttatact gcttgagaat gtatcgtatt atcaataata   559440
ttgaaacaat cttgctaacg gttatatgct taatgttatt gtttttttta agacgtttat   559500
ttgataaaga taagtaaata gatgttaagt aaaaatgtag aatataaagg aggtgcaatg   559560
agtatgattg aagttagcca tttatcaaaa agttttggtg ataaaatagc tttaaataat   559620
ataagcttca ctgttaaaga aggttagatt tttggatttt tagaaccatc tggttctgga   559680
aagaccacaa cgattaatat tctgactggg cagttccttg ccgataaagg acaatctatt   559740
attttgggac aaaaatctca aaatttaaca agcggtgaat taaagagaat tggattggtt   559800
agcgatacaa gtggatttta tgagaaaatg tctctgtata acaatcttct tttttatagt   559860
aaattttata atattagtaa atcacgtgtt gataatttgt taaagcgagt aggattatat   559920
gatagtcgca agatggtagc aggaaaatta tccactggaa tgaggcaacg aatgctttta   559980
gcacgagctc ttatcaacaa ccccgctgta ctctttctgg atgaaccgac ctcaggtcta   560040
gatcccacaa cttctcgaac aattcatgag ttaattttag aattgaaaac agcagggaca   560100
acgatttttc taacgactca tgatatgaat gaagcaactc ttttatgtga ttatgttgcc   560160
ttattaaata aagggaaatt agttgagcaa ggagctcctt ctgaactcat tcaaagatat   560220
aataaagata aaaagattaa ggttacagat tataatggga atcagataac ttttgatttt   560280
acatcactag aacaggtatc tcagactgat ctggaaaata ttttttcaat tcattcatgt   560340
gagcctactt tagaagatat ttttatcaca ttaacaggag gaaagctaaa tgcttaaacg   560400
gtttctggct ttggtatggt tgcgttgtca aatcatcctt tccaataaga gtattttatt   560460
gcaagtttta gtgccttttg ctttcacata tttttataaa tatcttatgg aaacacaggg   560520
gaaggtcaac gatcaacagg cattagttct tttgatgatg tgtttacctt tttctttttc   560580
tttggctgtt ggaagtccta taactattat cttgtctgaa gaaaaagaaa agtacaattt   560640
acaaactctt ctgttgagtg gtgttaaagg ctccgaatac attttatcaa ctatgtttct   560700
tccttttttg ctaacttttg tgattatggg aactactcct cttattttag gagttacaat   560760
tgtacatact tttaattata ttacaatcgt tcttctaacc tctttatcca tcattttatt   560820
ctatttattg ataggtttaa ccgcgaagag ccaagtagta gctcaggtta tcagtcttcc   560880
tgctatgatt ttagttgctt tcttaccgat gctatctggt ttggataaga cagttgcgaa   560940
gataacagat tatagtttta tgggactatt tactaagttt ttcacaaaat gggaggaatt   561000
ttcatggaat aaaactctaa ttcctaatct aacactactt atttggattg ttcttctatt   561060
aactttaatt acgataacta ttaggaaaaa gaaaatttct taattgagtt attttaatga   561120
ttataaacac aagtgggaag gaaaaaatga actgatcttt ttgacagcaa ttctacagaa   561180
tagtcttatt gctatatttt gatttgagtg tacgaaaaaa gaaaaataac aatagtgctc   561240
atactaattg cagaagtttt gggtgataag ataactgata aattgcaata aaaaatgcaa   561300
catttttaaa tctcctctat aagtgcttca aaaagtgctt caaaacctgt cttgtaatcc   561360
aagtattttt ggggacggtg attaataagc tagcaaagca tcattaagga ttttttcggt   561420
aattgttgcc aaatcggttt aagaaaatac tcacgaagaa gtccattcgc attctcatta   561480
cttccccttt gccaagatga ataggcatcc gcaaaataaa acagaattcc catttgttca   561540
attaaagggt aacaagcaaa ctctttttct ctgtccgaag tgaaagtctt taactattct   561600
tttggaaaga gtcttgtgag gtgttcaata gcagtcaaca tggatttagc tgtttttact   561660
tgacaagtgc tagtagaaat aatagaatag taaaaaacct ttaaagcagt ccagagaggc   561720
agctaaggtt agacggtgaa agggtggaga ctacccattt ttcgtggaac cttgctgttg   561780
gcaggttcct tttttcgtgg cttctgttgg ccagactctc tcactagtaa aggtaaaagg   561840
agaaacctat gcgagaacat cgtccaatca ttgctcttga ttttcctagt tttgaggcgg   561900
tcaaggaatt tttagctctt ttcccagcag aagaaagcct ttatctcaag gtagggatgg   561960
agctttatta cgcagcgggg cctgagattg tgtcctactt aaaaggtttg ggtcatagtg   562020
tctttttgga tctcaaactt catgacattc ctaatacagt caagtcagcc atgaagatct   562080
tgtctcagct tggtgtcgat atgactaatg tccatgcggc tggtggtgta gagatgatga   562140
aggcggcgcg tgaaggtctt gggagtcaag ccaaattgat cgctgtaact cagctcacat   562200
caacgtcaga agctcagatg caggagtttc aaaatatcca aaccagtctg caagagtctg   562260
tgattcacta tgccaagaag acagctgaag ctggcttgga tggtgttgtt tgctcggctc   562320
aggaagtaca agtcatcaag caggctacca atccagattt tatctgtctg acaccaggga   562380
ttcgtccagc tggtgttgca gttggagatc aaaaacgagt catgacacct gctgatgcct   562440
atcaaatcgg cagtgactat atcgtagtgg gacgtcccat tacccaagct gaggatcctg   562500
ttgcagctta tcatgccatc aaggatgaat ggacacagga ctggaattaa agaactagat   562560
tagaaaaata aaaggagaat accatgacac ttgctaaaga tatcgctagc cacctcttga   562620
aaatccaagc cgtttacctc aaaccagagg aacccttcac ttgggcatct ggtatcaagt   562680
caccgattta cactgataat cgtgtgacac tagcctatcc agaaactcgt accctaattg   562740
aaaatggttt tgtggaagct atcaaagaag cctttcctga agtagaagtg attgcaggaa   562800
ctgcaacagc agggattcca cacggagcca ttattgctga taagatggac ttgccttttg   562860
cctacatccg tagtaaacca aaagaccacg gagctggtaa tcaaatcgaa ggtcgcgtag   562920
ctcaaggtca aaaaatggta gtggttgaag accttatttc aacgggtggt tcagttcttg   562980
aagctgtagc agcagccaag cgagaaggag cagatgtact tggagttgta gcgattttca   563040
gctaccaatt gccaaaagca gataagaact ttgcagatgc tggtgttaaa cttgtgacgc   563100
tttcaaacta tagcgagctt atccatctag cccaagaaga aggttacatc acgccagagg   563160
gccttgatct tctaaaacgc tttaaagaag accaagaaaa ttggcaagaa ggttaggtca   563220
gtaagataaa gagagacgag gctaccgagt ctcttttacc attttattta aaatatgaca   563280
atattttaaa taaaataatt gacaacgctt tcttttgttg atataatgaa aatgtaatat   563340
gtatcaaatt gatcaatcaa ctatcttgtt tatcacttct taagaggacg atgtcatgaa   563400
aagaagaaaa atatattcct tttttgcgta gttacaaatg catctagttt gtttctccct   563460
acagttttag ctagacagat tggagattat gatttaacgt cgccgcgttg gggttcggat   563520
acaactagtg agcttgagaa agaaaactcc tctgctggaa ttaataataa tgacagcact   563580
ggtggcggta aaaggttaaa tacctctatt cgtagcgcct atagtgggtc agatattacc   563640
ccggtatatt cattggggtc tggctctagg attgtcatgt actataatgg aggtggtgac   563700
aattatattg gttctggtac tagattagct atggcgccac aatttggaaa tcatgtaaga   563760
attcatactt caggttcttg gaatccagat tcttattaac ttacttgtca gagtaagcct   563820
taaagatggt tgattgtggg tgtagcatga aaaaagaatg ctacacccta tttttattat   563880
aaggaggagt aaggatggaa tttttcattt gtaatcttgt acgagtcgtt caatcacctc   563940
gattttatat gtctttattt ttgacccttc tttgcatgag tttaggaaat ttccttgctt   564000
tcaatggtat ttataaaatt gaaggtttat cgattttttt tgccgcttct tctattcgag   564060
gattttcacc gattagccta gtagctgcac ttatctgtac actgccctat tctagtcaga   564120
taatagagga tgctgagagt cattttctaa cagcacaatt gtgtcgaatt tctaaaaaga   564180
agtatctggc tattgtgggt agtactgtaa ttatttcttc ttttctagtc ttttttctcc   564240
cctatttatt attattagga attaatcttt tagtgactcc ttatcaggaa atttatattg   564300
gagattatag tggtgcctta aaagaattat ttgattccaa tcagtttctc tatagtcttg   564360
taacgactct ctggtatgga gtttggggcg ctgtgttctc tatttttgga ctagctagtg   564420
ctttgctagt gaagaaaaaa ataggagcta ttttcatccc agttgcctat atgatggttg   564480
gtggtatttt ttgggctatt ttagggctat cttacttaga acctgtgaca acgctagctt   564540
tgggatatca gaaagatatc agtctttcct tagttagtgc tcatcttgct tttattttat   564600
ttgttagttg tttggttgtt tatggtacat tttttctaca ttcagaggac tatgtataat   564660
gaaacaattt gttcaatttt ataaaaaaga tttcttagca gtattggttt attttatatt   564720
actgctatcc tgtgttttat ctagtacagt atatttattg cgctgtcgcc aatattcaat   564780
ccatccaaat gtattagaat ggatcttagt tttacttcaa gatatgacga ctggagtata   564840
ttgctttccg ttcacatata tattgttctt tttttatttg atgaataact attttaatag   564900
gttggagtgt cgcattcgtc tgaaatcaat taagcacttt accagtttta gtttcaaatt   564960
agcagctctt agtacgggga tttggacggc gactttattt ttattgattt ttctaattgc   565020
atttagtaat ggttttagct tctctttgga gataaaggag gttgattttt taagagaatt   565080
ttatggtata agtattgcaa acaatgctag tttctttata ggattttttt tctcttatat   565140
agcatactat ttctttttat ccttacttac tattagcagt ttttcttggt ttaaaaaatc   565200
aaacatgagc ttagtatttc tgtttacttt tttatttgta gaatccttat tctggattta   565260
tcagttggac aatgggataa ttggattatt gccaattttt cagtatatgg taaattccaa   565320
tccgtatgca ttgatttatt ggcttacatt actatctatc ataattccat tgactgtatt   565380
ttctgttcat agaaactgga ggagagtgta aaagttggaa atgggaaagt taagtagtca   565440
catgtggagg ttgaatcaga taatctatac caagtacttt tggggttatg ttcttttttg   565500
gatattgatt tgtttaggat tatggtattg gttagaagga aatgatagac ttgttataga   565560
aattttaaaa gggcctaatc tgagtcaaaa ctctttttta gtcttatcta tatggttgct   565620
tcattggttt attattcata cattttttct agcagttgta tatcgtagaa gagcatccga   565680
tttctttatg gaagtgattc gattttcttc tattaagctc tggattaggt atcagatttg   565740
gacctgtttt ctttatggac tcattttaat catggtaaaa gttctagtga ttcaatttat   565800
gttacagtta ccaaactggg atataggagt tttgtttata gttgattctt tgaatgcttg   565860
tgtgttagtc ttgttttgct ttatgttata cgcactagga gcgaatgtac aaatgaactt   565920
tgcttgcgtt agtttctttt tactcatgat tgtgtttggt ggtctatttg taggaaatcg   565980
aactaattat ctattttata ttttgaatcg agggaatgga gatataggac gagatttatt   566040
tcttcagttg ctatttttag tctttctttt tcaaagcatt ttctatttca ctcgtcaaaa   566100
gaggaggttt atagaatgaa tgaaataatt acattaaaaa atattgagtt gaaattaaaa   566160
aagacatgtg tttttcaaaa ccttaacttt agttgtaaac agggggaaat tataggaatt   566220
actggtgcga atggctcagg gaaaagtgta ttgtttaaat taatagctgg tttatatagt   566280
ccgtcttatg gagaagtgtt aatcaatggg gaaaatattg ttcctgagag aaaaattcca   566340
gctaatttgg gagctttgat tgaagaacct ggttttataa attattatag tggctttaag   566400
aatttacaat atttggcaag catacgagga gtagttggta atcaggaaat caatgataca   566460
ctgaaaatag ttggtctata tgagcaaaaa gaccagaaag ttaaaactta ttcgctaggt   566520
atgaggaaaa agctagggat tgctcaagca attatggaga atccctctat tcttttacta   566580
gatgaaccta tgaatgcctt ggataaatca agtgtagaaa atatgagaac attgtttaga   566640
aagctctcta gtgaaaaagg gacaacaatt ttgattgcta gtcatagtga agaggatatt   566700
cgtatcttat gtgataaagt atatgcaata gaagataaag tatgtacact gtgttcagat   566760
tgaacatctt agatagactc aggatgttat aggtaaaatc ttaaaaaggg attggagctt   566820
aaaatccagt tccttttaag agttaatgac taatcaactt ttccaccttc aacaaccagg   566880
tcatctgctt tagcagcgtc accgtaggtt gggtgaagtg tcttttcata ggccttgtgg   566940
aagaagtttt ccttgcctaa tttttcaata tctttattga tgaagtctag caattcttgg   567000
ttgccttttt gaactgctgc cgcaatggta tcgggatcac cgagggaagt aattcctact   567060
tcaaatcctt tattttcaag cgcccaagct agaacttccg tattgtcagt tgaaaaggca   567120
tctccacgtc cgtcaagaag agcttggtaa gagtcactgt attggtcgta tttttggagt   567180
ttgatttctg gatgattctt ttcaaaataa gtctcagcag tcgttccttt tgtgacaatt   567240
aaggttttac cttcaagttg tttgacgtct gtaatgagac cagtcttagg tgatacgaca   567300
cccagagaaa ctttcatata tggaagggca aaatcaactt gtttcttacg ttcgtcagtt   567360
actgtaaagt tagcaagagt aatatctacc ttgtttgaaa tcaagtattc cgcacggttg   567420
gcagcatcga ctgaaatgta tttaaccttg acaccaaggt cttgagctag ttggttccct   567480
agttcaatat cgtagcgtag ccttggtaag aaccatcatt gtcaacgtag ccaaacggtt   567540
ttttatctcc aaacacggcg attcgcagtt caccgctttt tttgatttca tcgatagtgc   567600
gagctttggc agttgttttt ccagaggatg aaccagcgtt tccacctgag ctacaagcag   567660
tgataaagat aagggcaaag gcaagtgcta aaacagttaa gagtggtttg aatagtttca   567720
taagaatctc ctttatagat atgagccgaa ttggctaaag tcaaagacgt ttaaaaattc   567780
ctgggctcgt ttggtttgcg gattggtaaa gaaggcttga gctgttcctt cttcagcgat   567840
tttcccttgg tcgaggaaga taatccggtc agtaatggct tgggcaaact gcatttcgtg   567900
ggttactaaa atcatggtac ggccttcttg ggccaaatca ttgataagtt ccagcacctc   567960
acgcaccatt tctggatcca gcgaagcagt cacctcgtca aaaaggatga tttctggatg   568020
cattaggagg gcacggacaa ttgcaacacg ttgcttctgt ccaccagata attgacgggc   568080
aaagctatgt tgtttatcca gcaaaccgac acgctctagt aattgcaaag cttcttccgt   568140
tacttctttc ttgtcccttc cttgagcttt gatagggcct aggatgaggt tttgtaagac   568200
atccagatgg ggaaagagtt cataactttg aaagaccatg ccaatctttt ggcgaactag   568260
gtgaaaatct tttttatttt caacgataga ctgaccatcc agaagaatat ctccaccttg   568320
aatactttct aagccgttga ggcaacgaag gagggtactt ttcccacaac cagatggccc   568380
taggatgaca acaacttccc cttttttgat ttctagagaa agtccttgga ggatgggatt   568440
gtctccgaag gattttttta gttccttgat ttctaagata gtttcagaca tttagtttct   568500
ccaatgtttt tctaagtgag tggatagttt ggaaataggg tagcaaactg cgaaatataa   568560
gattagaatg gttccataaa tccaaaatga agcagttggg atggtcaggc gattgctatc   568620
gatgatttgt tgtccaactt tggtcacttc cacaacccca atcaaaacaa ctaatgaagt   568680
ggttttaatc atccgagtga caagattgat agcctgcggt agcagtcttc ttaagacttg   568740
tgggatgatg atgtggtagt aaagttgaac attagtcaag ccgagtgcct gtccactttc   568800
aaactgatgt ttagggagag aagtgatagc tccacgtacc aagtctccca tttcagctgt   568860
tccccagagg gtaaaaacga taatagctga agtctcacct gagatattga tattaaagtt   568920
tcgagccaag ccaaagtaaa cgatgaagag tagcaccagc tggggcatga tacggataaa   568980
ttccagatac aatcgtgtta aaaatcgtat gattctagaa tgggaggtca tgatgattcc   569040
catgactgtt ctgaacatca tggataagag gacagacagg atggatatcc caatcgtaac   569100
gcccaatccc tgtaagattc tcaggagatt atttccttga aagagtactt ggattcccga   569160
atcctgcatg gcggagcctc ctttctatcc agctaaagac cagtgagatg ggtagcagca   569220
tgattagata agcaactacc aacatagcta gcgcaatgtc tgtctcatag tagagaccaa   569280
tcaaatcctt ggcgacgtac atgaggtcgg ccaaagccac tgctgagaaa acagaggttt   569340
ccttgataag gaaaatgaca ttggcactaa aggaggggag tgccaccgct gttgcttgcg   569400
gaagaaccac atagtaaaag acctgtagag gtgtcagacc aatagcgagg ccaatctcct   569460
gctgggtttg actgatggct tccagcccac ttcggaaaga ttctgccata taggagcctc   569520
ctaaaaagac aagcccaagc gttgcacaga cttctgaaga taggacaatc ccgattcggg   569580
gaagaccgaa gtagagaaag aagagttgaa tcaaaagggg cgtattacgt gacaattcaa   569640
tgtaggctgt cgctacttgc gccaaaacaa ggattcgata atgtcggatg atactaacga   569700
ttaaaccgag cagaaaggat cccaaaattc cccaaactgc aatatgcaag gtcagaaaga   569760
atgccttttg atatagtggt agatattgtt caacaatgga tcaatccaaa aatagaacct   569820
cccatctaga aataatacag ttattgtagc acttaaaatc ttctttggat aatatctatt   569880
ttttattgcc gttataagga tttttatcat agacataaaa tttctgaaat ttccaaacaa   569940
aatattttaa aagttttgaa aaagagttaa gatatttttg taatacacaa agtaaacgct   570000
tacttattaa ggaggacatt ttatgtcata caaaacaagc aatgcagaag gtcatgtaga   570060
tttcatcaat acctatgatt tggagccaat ggcgcaacaa gttattccta aagcagcatt   570120
tggctatatc gctagtgggg cgggagatac tttcacttct ttccagtgat tttagcgtca   570180
ggttcttttt agtttttaaa gattatccgt gaatttcttg cttatttatg ataaaatggg   570240
agtgtcgcaa aaaatgactc atcgtattca attttgagta aaactaggag gatcccatgt   570300
ctacagaaca tatggaagaa ctaaatgacc agcagatcgt tcgccgtgaa aaaatggctg   570360
cgctccgcga acaaggaatc gatcctttcg gaaaacgttt tgaacgtact gcaaattcac   570420
aagaattaaa agataaatat gccaacctcg ataaagaaca attacacgat aaaaacgaaa   570480
cagctactat cgcaggacgc ttgataacca aacgtggtaa aggaaaagtt ggttttgccc   570540
accttcaaga ccgcgaaggc cagattcaga tctacgttcg taaggatgct gtcggtgaag   570600
aaaactacga aatcttcaaa aaagcagacc ttggtgactt ccttggtgtc gaaggtgaag   570660
tgatgcgtac ggatatggga gaactctcta tcaaggcaac ccacatcaca cacttgtcta   570720
aggctcttcg tcctcttcct gagaaattcc atggtttgac agacgttgaa acaatttacc   570780
gtaaacgtta ccttgacttg atttctaatc gtgaaagctt tgaacgcttt gtcactcgtt   570840
caaaaatcat ctctgaaatc cgtcgttacc ttgaccaaaa aggattcctt gaagtggaaa   570900
cacctgttct tcataatgaa gccggtggtg ctgctgcccg tccatttatc acccaccaca   570960
atgcccaaaa cattgacatg gtgcttcgta tcgcgactga gcttcactta aaacgcctta   571020
tcgtgggtgg tatggaacgt gtctatgaaa ttggccgtat cttccgtaac gaaggaatgg   571080
acgctactca taaccctgag ttcacttcta tcgaagttta ccaagcttat gcagacttcc   571140
aagacatcat ggacttgact gaaggcatta tccaacacgc tgctaaatca gtcaaaggtg   571200
atggcccagt caactaccaa ggtactgaaa tcaagattaa cgaaccattt aagcgtgttc   571260
atatggtgga tgctatcaga gaaattactg gtgtcgattt ctggcaagac atgactttgg   571320
aagaagctaa agctatcgct gctgagaaga aagttccagt tgagaaacac tacactgagg   571380
ttggtcacat catcaatgcc ttctttgaag agtttgttga agaaacttta atccaaccaa   571440
cctttgtcta tggacatcca gtagctgtat ctccactcgc taagaaaaat cctgaagacc   571500
aacgctttac tgaccgtttc gagctcttta tcatgactaa ggagtacggt aatgccttta   571560
ctgagttgaa cgacccaatc gaccaactta gccgttttga agcccaagct aaagccaaag   571620
aacttggtga tgatgaagcg acaggaatcg actatgacta cattgaagct cttgaatacg   571680
gtatgccacc aacaggtggt ttgggaatcg gtatcgaccg tctctgcatg ctcctcactg   571740
atacaacaac tatccgtgat gtattgctct tcccaacaat gaaataaatt cttatcctct   571800
gggtcttatc agaggatttt ttgattcaaa aagagactga atttaaggag aaaatgaagt   571860
gtagtatatt gaaattgaaa tagtacactt tgatttctaa gacattgtta gaaattggtt   571920
taaattccct aagcaatttg tgcatgtttt atttcatttt acgatagtac gctgaaactt   571980
ttcaaaaagt actagaaatt gacttggatt ccccaattga tttgttcaga ttcactataa   572040
ataaaaaatt aataagtggg ataggaagtt agcgtcaact aggatagtat cttgcttaaa   572100
cagtatatat gggattgata taagtccata ggtcctatta gaggatgttc tggtgtctta   572160
ttcacttgtt ttttatagta ttagtagata gaatcagcaa ataaaaaccc aaatcattca   572220
tacctctctc aactagatgt aacttacaaa acccctgacc tcatgagcca ctttcttcct   572280
cctcatgagg tcagttttac tttctgctgt tccagtatcg tttttcctcg ctagatttcc   572340
tcaaaagggc agactcctcc cttggtgcgt cacacgattt tttcatctcg actgttcttt   572400
aatgcatcat taacgacgct tttcttctag gtggttcata aggaacagga agattcaggt   572460
tgacttttct aatcctagaa taaagtgctg aaaacaattc ggaataggca tagagactag   572520
acaatttgag gagctgcttg cgtcctgttc gaacacattt tcccaccacg tgaagaaaaa   572580
gatggcggaa gcgtttgatt gttaaagttt ggaagtcacc tccagctaga tgtttgagaa   572640
aaagatagag attgtaggcg atacagctca tcatcatacg aacttcgttt ttgattaagg   572700
ttgaactatc cgttttatcg ccaaaaaatc cctccttcat ctccttgatg aaattctcgg   572760
cttgaccacg tccacgataa agctgaaact ggtcttggct tgttccactc gtcatatttg   572820
taacgagaga aataacatcg tagaacaagt ttccttcttt tcgttcagag aactggcaga   572880
cacgacgctt gtgcgaccaa gatcctgctt gatagagagt ttctgagtag gcggagtggg   572940
gcaagatggt taagtcctca tcctgtgggc aagggaggga aaggtctcca agacggctca   573000
gaacagtatt tttcttgagt tttatgaggt agtattgccc tgttttttca attaaatcgt   573060
ataattttgg ggtcgcaaag ccactatcca ttcgaaagag aagttgatta aaccgttcta   573120
aaacaggtgt gataaagctg tctgcctctt cagaacaata acgattacca ggacgaagct   573180
gggcattgaa acaataacct gtcttcccct cgaaagcata aagaggatga tagccatgag   573240
cacgatagtg ggcgttataa gcaacacctt cttgcttgcc ataagttgtg aaatgggtag   573300
aatcgatatc tacaatgagt tggtttagct ggtgaaactg taaaaagaat tcgaccaatt   573360
caaggttgag gcatcgcaaa ctatggactg tttcctcgtc agttctggaa agaaaacggg   573420
ataaggttgg ctgtgaagca agctgccctc cttccaacaa ttttggaaag taggcatcag   573480
ctgacaattc tttacaagca tagtccgttc cataacctgt taacagttga aagaggaact   573540
ggacaaggat atctgaatcc gaataacgac agtagcggcg ttggtcattc gttactaaat   573600
acttagaaat ccgctctttt agtttcaact gggaaaaaag ttcctgaaaa aagataagac   573660
caccatactg ggttaaatga cctccatcga aagatagttg gtaaaaagac ttgttttgga   573720
agtgatgatt tggtaaactg ttcatgtgag tttcctttct ttttgtgttt ttttctacac   573780
ttataccata aaggggaaac tcttttttgt ctagtaaaaa acacccattg ggtgaaaaaa   573840
gaaaccatcc aggatctaag ctaaggcaag gattctggat ggtttttaga tttggggtga   573900
ataattgggg aaaaagtagt tcaaatgcct ggcagcaaaa aatctcaacg attcacttaa   573960
tatagactaa ggtttagagt ttaaggaaag tagggctagt atattgtatg aaaaaataag   574020
atggttttta agcaaaactc ttgaaaatga ttgaaaaaag agttattata gttgtatagt   574080
aaaaagcaaa cgcttactta atcgaggagg acagtttatg tcatacaaaa caagcaatgc   574140
agaaggtcat gtagacttca tcaataccta tgatttggag ccaatggcgc aacaagttat   574200
tcctaaagca gcatttggct atatcgctag tggggcggaa gatactttca ctttaagaga   574260
gaatatccgt gcctttaacc acaagctcat cgttcctcat acactttgca atgtagaaaa   574320
tccaagtaca gagattgaat ttgcaggtga aaaactatct tctccaatca ttatggcacc   574380
tgttgcggct cataaattgg caaatgaaca gggggaagtg gcgactgcgc gtggtgtgca   574440
tgagtttggt tctctttata caaccagttc ttactctact gttgaccttc cagagatttc   574500
tgaagccctc caagggacac ctcattggtt tcaattttac tttagtaagg atgacggtat   574560
caaccgccac atcatggacc gtgtgaaggc tgaaggttat aaagcgattg tcttgacggc   574620
agatgctact gtagggggga atcgtgaagt ggataagcgt aatggttttg tcttcccagt   574680
tggcatgccg attgttgaag aatacctgcc agaaggtgct ggtaaatcaa tggactttgt   574740
ttacaaatca gctaaacaac gcttgtctcc acgcgatgta gaatttatcg ctgaatactc   574800
tggtcttcct gtgtatgtca agggaccaca atgccgtgag gacgttgaac gttcgcttgc   574860
tgcaggagct tctggtatct gggtaaccaa ccacggtggt cgtcaaatcg acggtggacc   574920
agctgccttt gactcgcttc aagaagtggc agaagcagtt gatagacgtg tgccgattgt   574980
ctttgactct ggtgttcgtc gtggtcaaca cgtctttaaa gccttggcat caggagcaga   575040
cttggttgct attggacgcc ctgtcatcta tggcttggct ctcggtggta gtgtcggtgt   575100
gcgtcaagtc tttgaacact tgaatgcgga attgaagaca gttatgcaat tgtctggaac   575160
tcagaccatt gaagatgtca aacacttcaa gctccgtcac aatccataca acccaacctt   575220
cccagttgac cctcgtgact taaaattgta ttgataaaac agattgcctc cactgaatgt   575280
ggaggttttt cttcgtgtat tggaagaata aattgctatc gaaaactata gtaaaatgaa   575340
ataagaatag gacaaatcaa tcaggacagt caaatcgatt tctaacaatg ttttataagt   575400
agaggtgtac tattctagtt tcaatatatt atatataaag atatttttcg gtcaaatatc   575460
ttgctagggc tttcattttt tgctatactg gttcagtagt taaataatag agacatttgg   575520
ggtgctttag gctgagataa tacccattga acctgataca gttaagactg gcgaagggaa   575580
atgtgaacag ttttttcgta tggtgaaatg aacggtctaa tcttgtaagt caactctaat   575640
tcttgattgt aattggagtt ttttgtttat ataaactgga taggcttgtt tagttagctc   575700
tctgcaaatg ctctcgatgt gctttaaaag gatcaagtgg aattacgatt ttgcttgata   575760
tttcttggtg ttttattaat tactaacaag taaagagagg agaagtaaat atggaaacac   575820
aagactatgc atttcagcca ggtttgactg ttggagaatt attaaaaagc agtcagaagg   575880
attggcaggc tgcaatcaat catcgttttg ttaaggaact ttttgcgggg acaattgaga   575940
ataaggtctt aaaggactat ctgattcaag attatcactt ctttgatgcc ttcttatcca   576000
tgctgggtgc ctgcgtagct cacgcagata aacttgaatc caagcttcgt tttgccaagc   576060
aactaggctt tcttgaagca gatgaagatg gttatttcca aaaggctttt aaagagttaa   576120
aagtagcaga gaatgactat ctagaagtga ctttgcaccc tgtaacaaaa gcctttcagg   576180
atctaatgta ttcggcggtg gcttcatcag actatgccca tcttttggtc atgctggtca   576240
ttgcagaagg tctctattta gactggggtt ctaaagattt ggctttacct gaagtctata   576300
ttcattcgga atggatcaat ctccacagag gtcctttctt tgcagagtgg gttcaatttc   576360
tggttgacga actcaatcgt gtcggtaaaa atcgagaaga tttgacagaa cttcagcaac   576420
gctggaatca agcagtcgct ttagaattag ctttttttga tattggttac gatgtctaga   576480
gaaggctcat gatatttaca aatttgatga ggtaagactc ttcgaaaatc tcttcaaacc   576540
acgtcagttc tatccacaac ctcaaaacag tgttttgagc aacctgcggt tagcctccta   576600
gtttgctctt tgattttcat tgagtataaa tcattcaatg taaatgaaaa aaattctcaa   576660
ctaaagataa atcgaaatta gtagatcgta taaagtgaaa aggaaggatt tcaatatgac   576720
aagtttaaaa ttattaaaag aaaaagcacc attggtcatt tgtataacca atgatgtagt   576780
aaaaaatttc acagcaaatg gattagtagc actgggcgcc tcaccagcca tgagtgagtt   576840
tccagcagat ttagaggatt tgttaaagta tgctggtggt ttattaataa acataggaac   576900
attgacagat gaaaattgga aattatacca agctgctctg aaaattgcag agaaatataa   576960
tgtcccagca gttttagatc ctgtagcctg tggagcagga gaatatagaa aaaaagtagc   577020
agatgatcta atcaacaatt ataaactagc agcgattaga ggaaatgctg gcgagattgc   577080
ctctttagta ggaatagatg tggcatctaa aggagtagat agtgcgggcg tagataatat   577140
tgacgaaatt gctctagcag caaatgagaa gttcaatatt ccaatagtag taacaggtga   577200
agtggatgcc attgctgtta atggagaagt ggtaatgatt cataatggta gtgctatgat   577260
gccgaaagtc attgggacag gatgcttatt aggagctgta gtagcaagct ttatcggact   577320
agaaaaaggt caagaattga aatcattaaa aacagcagtg ttggtttaca atatcgctgg   577380
agaaatagca gaaaaacgtc caaatggaca tcttcctggg acatttaaag ttgaatttat   577440
aaatgcctta tacgagatta cagatgaaga tgtaaaggaa ttcaaaagag tgaagtaaga   577500
tgtttcataa agaattacta aaactatatt ttatttgtgg aacgactact tgccaaggaa   577560
aaaatctata tacagtcgtt gaggaagcct taaaaggtgg tataacctta tttcaatttc   577620
gagaaaaagg tgagggtgct ttagaaggct tagaaaaact tgagctagct atccaaatta   577680
aagaactttg taaaaaatac aatgttccat ttatcgttaa tgacgatata gatttagcaa   577740
tggaaattga cgccgatggc gtacatgtag gtcaagatga tattggtgtt gatgaaatta   577800
gaaaattgat gccagataaa ataattggtc tttctataag aaacgaagaa gaatttcaac   577860
aatcaaaagt tgaatatgta gattatgtag gtgttgggcc tgtatttggt acccagtcaa   577920
aggatgatgc tggtggtact ataggttatg aaggtcttga attgatgaga aaactattgc   577980
cacaaatgcc tttagttgca attggtggga tacagacgaa acatattaaa gacattataa   578040
agaccaatat ggatggcgtt tcaatcattt cggcaatatc gtatgcaaaa aatatagaaa   578100
aaactgttcg ggaaatgagt gaacaataga tatctatcct tggattctaa gtaagtagga   578160
ttttcctttt ttaaaaagct atgtccagat tcagcttgaa tggctaattc atcaaacagg   578220
tcatttgttt tttgcaaaag aaagatctgc tgtctttgtg agtgcaaggc tgtatttcca   578280
gttcaatttc ttgaactagt ataaaatgtg tgttataata atcacataat taaataataa   578340
agacatttgg ggtgctttag gctgagatga tacccattga acctgataca gttaagactg   578400
gcgaagggaa atgtgaaatg tttttttcgt atgtcgaaaa gaactgtcta atcttgtaag   578460
ctgaactcta atttgtatct gtaattagag ttttttcttt tacgaaactg gatgaagatg   578520
atatagtaga ttgaaataag atgcgaacaa atcaattaga aaattcaaat taatttctag   578580
aaatatttta gtgttcttgt gtactgttct aaattcagtc tgctatacaa agtatttagg   578640
tcggtcttct tgagtgcctc acttttcttt aaaaaaagga gttttttatg ttgaaaaaat   578700
ggcagttaaa agatgttatc ttgcttgctt tcttgtctat cttttttggt ggggttttcg   578760
ttggttcagg atatgtgtat aatattctca gtctactctt aacacctctt ggtttgcagg   578820
cctttgccaa tgaaatcctc ttcggtctct ggtgtatggc tgcgcccatt gctgccatct   578880
ttgttccgag agtcggaagt gcaacgattg gagaagtgct agctgcgctt gctgaagtcc   578940
tttatggtag ccaatttggt ctaggagctc ttttgtctgg ctttgttcaa ggtttgggaa   579000
gtgaatttgg ttttatcgta actaagaatc gctatgaaag ttggctctct ctaactgcta   579060
atagtattgg gattacgctt gttagctttg tctatgaata cattaagtta ggttactacg   579120
ccttttccct tccgtttgtc ctttccttgc ttgtggtacg ttttatttct gtttatttct   579180
tctgtaccat cttggttcgt gccattgtca aactctatca tcagtttgca actggaggaa   579240
aagcatagat gggtctggaa ctacgagcga ttcagtcccc aatcttctct gagccgtttg   579300
attttacttt tcatgcgcaa gcctttacct tgttagttgg gagtagtggg tctggaaaat   579360
ccagcctctt tcaaatgatt gcccaagtta gttctcttcc ctatagcggt caagtcctga   579420
tagatgggag cgaggtcagt cagctttcta tcgtcgaacg tgtccagacg gttggtattc   579480
tcttgcaaaa tcctaatcat caatttacca tggagagctt gtttgaggag ttggttttta   579540
ccatggaaaa tatcggctat caccttcagg aaattgattc taaaatagca gaggttgtcc   579600
agcaatgtcg ttgcaaggac atcttgcacc gtctcatcca tcacttatca ggtggggaaa   579660
agcaaaaagc agcgctggct gtcctctttg ccatgaatcc tagggtctat ctcttggatg   579720
agcccttcgc ttccattgac cgcaagagca gaatcgagat attggagatt ctaaaagagt   579780
tggtctatga tgggaagaca gttattttgt gcgaccatga tttatctgac tataaagcct   579840
atatcgacca tatggtggag ctaagagacg gaaaactaag ggaagtgttt caaatccctt   579900
cctatgagat gacacaggtt gcttcaaagg aagttgcttc tagcccggaa ctattccata   579960
tgaaccgtgt gactggtgag cttggtaatc gccccctctt ttcaattgct gatttcacat   580020
tctatcaagg gatttcctgt atcctgggtg acaatggtgt cgggaaatca accctctttc   580080
ggtctattct tcaatttcaa aagtataagg ggagcattac ttggaagggt tcggtcctga   580140
aaaagaaaaa gagtttgtat cgtgatctga ctggtgttgt tcaggaagct gagaagcagt   580200
ttatccgagt cagtctgcga gaggagcttc aattagatgg acctgattct gaaagaaatc   580260
agcggatttt tcaagcttta cgatattttg atttggagca ggcagtcgat aagagtccct   580320
atcaattaag tggtggtcag caaaaaattc ttcagctcct gaccatcttg accagtaagg   580380
cttccgtgat cttgctagat gaaccttttg caggtttgga tgatagagcc tgccattatt   580440
tttgcaagtg gattgtggag gagaggaatc aaggaagaag ttttctgctc attagtcatc   580500
gtttagaccc tttgatttct gtggttgatt attggattga gatgactagt cagggtcttc   580560
ggcatgtgaa agaagtgacc attaccaaac cacttacatc tcagagtagc aatacccaag   580620
gggaggtgag atagtatggt caaagtagca acccagacac cgattatcag tctcttcttg   580680
ctgattttat ccttggaaac atctttcatt ccttcgattg ctctgactct ttcggtagtc   580740
gcattttgta ttctctttat gctctattac cgtcgattta aaatgttagc ttggatgatc   580800
atacttgcca ttttaccatc ttttgccaac tactgggcag ttcagttaca cggagatgct   580860
tcacaggcag tcatgcttgg aacgagggcc tttgtgacag tttgtatcgg ccttgtcttt   580920
gtttcctctg tttcactaaa agagcttctc ttgtacttgg ctcaaaaggg gctatcacgc   580980
tcttggtcct atgccttgat tgtggtattc aattcttttc ctctcattca gcaagaaatc   581040
aagtccctca aagaagcttg cctattacgt ggtcaagaac tacatttttg gtcgcccttg   581100
atttacagta aggttctgat gacagtcttt aggtggcgcc atctttacct gagagctcta   581160
tctgctcacg gatatgacga acatgcacag ttgaagaata gctatcggac tttttatatt   581220
cctaaaaaaa caaaattaat ctacctgctt ttctttttat tgcttcaaac cagtctattt   581280
ttataaagga gttattatgg aatttacaga tattgcgatg gaattatcca agaaagcttg   581340
gcaggcttcc tttcatcatc cctttatttt acaattacaa gaggggaatt tagaacctgc   581400
cattttccgc tattacctga ttcaggatgc ctactatctg aaggctttct cagaaatcta   581460
tcatcttttg gctgataaga cttcaaacca agagatgaaa agactcttga aacaaaatgc   581520
tcagggttta gtggagggtg agttatttat tcgccaacaa tttttcaagg aattggaaat   581580
cagcgaccag gaaatggagc aacatccaat cgctccaacc tgttatcatt acatttctca   581640
tatttatagg caatttgcag aaccgaactt agccatcgct tttgcaagct tgcttccttg   581700
tccttggtta taccatgata taggcaaatc acttaatctt aaaccatcac caaatcctct   581760
ctatcaacaa tggattgaaa cttatattac ggatgagtta gagcaacaga tcagagagga   581820
gggagcactg gtcaatcagc tctatcgaga aagtgacgag acagacaagc aaaaaatgct   581880
agatgccttc cacatcagtg ttcatatgga agccaagttt tgggaaatgg cctaccaaca   581940
ccagacatgg aagagcgatt tacagtcttt agaaaaagga gaagaataga agcatgagaa   582000
agcaccaatt acaagttcac aaattaacca ttttatctat gatgattgcc cttgatgtag   582060
tccttacacc tatctttcga attgagggaa tggcaccgat gtccagtgta gtcaatattc   582120
tagcaggaat catgatggga cctgtttatg ccttggctat ggctacagtc acagccttta   582180
tccgtatgac gactcaaggg attccgcctt tagctctcac aggagcgact tttggagccc   582240
ttctagcagg tctcttttat aagtacggtc gaaaatttca ctattctgct ctaggagaga   582300
ttttgggaac aggtattatt ggttccattg tttcctatcc tgttatggta ctctttacag   582360
gatcagctgc taagcttagc tggtttatct acacgcctcg atttttcgga gcaaccttga   582420
ttggtacagc gatttccttt attgcctttc gatttttaat caagcaggaa ttctttaaaa   582480
aagtgcaggg atatttcttt agtgaaagga tagactgatg caggaattta caaatccctt   582540
tcctataggc tctagttccc tcattcactg cattaccaat gagatttctt gtgagatgct   582600
ggcaaatggg attttggctc tgggatgcaa acctgtcatg gcagatgatt cccgtgaagt   582660
tcttgatttt actaagcaaa gtcaggctct cttcatcaat ttggggcatt tgtcagctga   582720
gaaggaaaaa gcaatccgca tggcagcttc gtatgcaaac caatcttctc tcccgatggt   582780
agtagatgcg gttggcgtaa cgacttcatc cattcgtaag agcttagtta aagacctttt   582840
agactataga cctacggtcc ttaaaggaaa catgtcagaa attcgaagtc ttgttggatt   582900
aaagcaccac ggcgttgggg tcgatgcgag tgctaaagat caagaaacgg aggatttgct   582960
tcaagtcttg aaagactggt gtcagaccta tcctggtatg tctttcttag tcacaggtcc   583020
caaggacctc gtcgtttcga aaaatcaggt cgctgtactg ggaaatggct gtactgaatt   583080
agactggata acagggacag gagacttggt tggagcctta acagctgttt ttctcagcca   583140
aggaaagact ggttttgaag cttcttgctt agcagtctct tatctcaata tcgctgctga   583200
gaaaatagtt gttcaaggaa tgggattgga agaatttcgt taccaagtac tcaatcagct   583260
ttcgctccta agaagagatg aaaattggct agataccatc aaaggagagg tttatgaata   583320
gagaagcact tagactatat ctggtaacca atcgctatca agattccgtg gaaagctttc   583380
ttgcaaaagt tgagacggcc tgccgttcag gggttaccat agtccaattg cgagaaaaaa   583440
atctcacaac caatcaatat tatcaactgg caaaacaagt caaggaaata acagatgctt   583500
atcaggtacc cttgataatc gatgatcggt tggatgtttg tcttgcggtt gatgcagcag   583560
gtctgcatat cggagatgat gaattaccag tttcggtagc tcgcaaagtc ttgggtcctg   583620
aaaaaatcct cggtgtcacc gctaaaacgg ttaaaagagc tctggaagcg gagaaatcag   583680
gtgcagatta cttgggtaca ggagccattt tcccaaccac caccaaggaa aatgcgccca   583740
ttactctgat atcgaccttg aaaacaattt gccaaacggt tgccattcca gtagttgcta   583800
ttggaggctt gacttcggag aatattgatc agcttatggg cactggcata gctggtgtag   583860
ctgttgtacg tgatttgatg caagcagaag atattgaggc aaaaacgcaa gcctttttaa   583920
aaaagttgca taacattctt tcctaattaa tactcaatga aaatcaaaga gtaaactaga   583980
aagctagtcg caggttgctc aaagtactgc cttgaggttt tagataagac tgacgaagtc   584040
agctcaaaac agtgttttga ggctgcagat ggaagctgac gtagtttgaa gagattttcg   584100
aagagtataa aaactctcta attcccttaa agtgggaact agagagtttt ttttcttaat   584160
ctttaaaagt tgtatggttg actggaccag aaccatgacc gagttgaggg gcatcttgaa   584220
tagcttttgt gataaaggcc ttggccttat caactgcctg gtaaagactc ttgcccttgg   584280
ctagttcagc agtaatcact gcagcaaagg tacatccagt accatgggtg tgacaggttt   584340
gaattcgtgg gctttcccag acaaattgtt cattcttggt aaagaggaaa tctttagcac   584400
cacctttgag atgtccgcct ttgataacca cagactgagg accaaattct tttaaaatca   584460
ggcgaccagc acgctgcatg tcttcggggt catggattga aaaaccaaca atctcttctg   584520
cttcaggaag atttggcgta ataatagttg ctagaggtag taagtttgtt ttgagatagt   584580
ctctagcatt tgagtcaatc aaggcatctc cacttgtagc aaccataaca ggatcaagga   584640
catagggaca atccagtttt ttaagatagg gttggatgat ttccatgatt tcagtagtag   584700
ccaacattcc agtttttaca gcctgaggtg gaatatcaga aaagacactc tccaattggg   584760
ctttcaacat ttgaggagaa acgtgctcga ttagctgaac acctctggta ttttgagcga   584820
caagactggt tacaacagcc attccataga catctctcgc ttggaatgac tttaaatctg   584880
ccataatgcc agcaccacca ctagggtcag tccctgcaat ggtcaaagca acgggtaaat   584940
aagtcatcta aaacctccca accaactgaa gtttgtattc ttaagaacaa gctagtctgt   585000
tttagaaagg caatagaaga ctgctagtcc ccattatcat ttccacttcc atcagctagc   585060
attacctaga ttgagtcaga gggatctaac agtcgttaat ctcagcttta cgcaccccta   585120
gtggttgttt tcttttttct ttagtatagc atatttttat tgtttatata gtaatatttg   585180
actgcaaatc gtttttcaaa tgattaaaat tctatttttc gaagaaaata ttatttctat   585240
aattgacaaa tgtagatttt aagagtatac tgatgagtgt aattgacaaa tgtagatttt   585300
ggaggtatgg taatgcagat ttcagatgca gaatggcagg tcatgaagat tatttggatg   585360
cagggggagc agaccagtac agatttgatt agggttttgg cagagcggtt tgactggtcc   585420
aagtccacgg ttcagacact tttggctcgt ctggttgata aagagtgttt gactcggaaa   585480
aaagaaggca agtcctttgt ttattcagcc cttttaactc tagaccaaag tcgggattta   585540
cttgtccaag atatcaaaga caaggtttgt tcccgtagga ttaggaattt gttggctgac   585600
ttgattgtag aatgtgaatt tactcagact gacttggaag acttggaagc tgtgatttca   585660
gagaagaaat caagtgctgt aacagaagta agatgtaatt gtatgtaaag gagacgtcat   585720
gttaaatagt attgtaacca ttatttgtat tgcccttatc gcgtttatct tgttttggtt   585780
tttcaaaaag cctgaaaaat ctggacaaaa agcccagcaa aaaaacggat accaagagat   585840
tcgagtggaa gtcatgggag gctatactcc tgagttgatt gtcctcaaga aatcagtgcc   585900
agcacgcatt gtctttgacc gcaaggatcc ttcaccatgt ctggatcaaa ttgtttttcc   585960
agattttggt gtacatgcga acctgccaat gggggaagag tatgtagtgg aaatcacgcc   586020
tgaacaggct ggagagtttg gctttgcttg tggtatgaac atgatgcacg gcaagatgat   586080
tgtagagtag gtggagacta tgacagaaat tgtgaaagca agcttagaaa atggcattca   586140
aaaaatccgt atccgagctg aaaaaggcta tcatccagcc catatccagc ttcaaaaggg   586200
aattccagct gagattacct ttcatcgtgc tactccttca aactgttata aggaaattct   586260
gtttgaagaa gaaggtatct tggaaccaat cggcgtagat gaggagaaag tcattcgttt   586320
tacgcctcaa gaattagggc gacatgaatt ttcttgtggc atgaagatgc aaaagggaag   586380
ctatacagtc gttgagaaga ctcgaaaatc tctatctctc ctgcaacgtt tttggattac   586440
tagtatcttt actgtgcctc ttgtgattct catgattggg atgttgacag gtagcattag   586500
tcatcaagtc atgcattggg gaacctttct agcaacaacg cctattatgt tagttgcagg   586560
taagccatat atccagagtg cttgggccag ttttaaaaag cacaatgcca acatggatac   586620
cttggttgcg ctgggaactc tagtggctta tttctatagc ctagttgctc tctttgctgg   586680
tctccctgtt tacttcgaaa gtgctggatt tatcctcttt ttcgttcttt tgggagcagt   586740
ttttgaggaa aaaatgagaa aaaatacgtc ccaagctgtg gagaaattac tggacttgca   586800
agctaaaacc gcagaagtct tgagtgatga tagttatgtc caagttcctt tggaacaagt   586860
caaggtaggc gacctgattc gagtgcgtcc cggtgaaaag attgctgttg atggtgtcgt   586920
agtagaaggt gtctctagta ttgacgaatc catggtgaca ggtgagagtc tgcctgtgga   586980
caagacagtt ggagatactg tcattggctc aaccatcaat catagtggaa cgcttgtctt   587040
tagagcagaa aaagttggct cagagactgt tttggctcag attgtggatt ttgtgaagaa   587100
agctcagaca agtcgtgcgc cgattcagga cttgacggat aagatttcag ggatttttgt   587160
cccagtagtt gtcattttag gaatcatgac cttttgggtt tggttcgtct tgctcaggga   587220
tagtgtggtt gtgcttggag ctagctttgt gtcctctctt ctctacggag tggcggtttt   587280
gattatcgcc tgtccttgtg ccttgggact tgcaacaccg acagccctta tggtggggac   587340
aggacgtagt gccaagatgg gggttctcct caaaaatgga actgtcttac aggaaatcca   587400
gaaagttcaa acccttgtct ttgataagac cgggactttg acggaaggga aacctgtggt   587460
aacagatgtc atcggcgacg aagtagaagt gtttgggttg gcagcctcct tggaagatgc   587520
ttctcaacac ccactggctg aggctatcgt taagcgagcg agtgaagctg gacttgagtt   587580
tcaaactgtt gaaaattttc agtccttgca cgggaaaggt gtttcagggc gaatcaatgg   587640
aaaacaagtt ttacttggaa atgctaaaat gctggatggc atggatattt ctaatactta   587700
tcaagataaa ctagaagaac tagaaaaaga agctaagaca gttgtgttct tagctgttga   587760
caatgaaatc aaaggcttgc ttgctttgca agatattcct aaggaaaatg ctaagctagc   587820
catcagtcag ctaaaaaaac gtggtctccg aacagtcatg ctgacaggag acaatgctgg   587880
tgtggcgcgt gctattgcag atcaaatcgg aattgaagag gtcattgcag gcgtcttgcc   587940
agaagaaaaa gcccatgaaa tccataaact gcaacagtca gggaaagtag cctttgttgg   588000
ggacggtatc aatgacgctc ctgcccttag tgtagcagat gtggggattg ctatgggagc   588060
tggaacagat atcgccatcg agtcagcaga tttggtgttg acaaccaata atcttttagg   588120
agtggttcgt gcctttgata tgagtaagaa aacctttcat cgaattctac tcaatctttt   588180
ctgggctttt atctacaatg ttgtcggaat tccgattgca gcaggagtct tttcaggtgt   588240
tggactggct ctcaacccag aattggcagg tctagccatg gcctttagtt ctgtatctgt   588300
tctgaccagt tcccttctgt taaattttag taaaatagac taaaagtaat gactagattt   588360
ctttgttata aaacagaaat gacagaactt tcaaaactgt attagaatag agaatagaga   588420
gttttgagca gatttttaga aaagtcagca taaatatgat acagtggaat agtaaaaatt   588480
tggagaacgt ttccaattct atgtaatcgt attctccaag tttaaaaaaa ttgaaggaga   588540
gttatcatta tgactcaagg gaaaattact gcatctgcag caatgcttaa cgtattgaaa   588600
acatggggcg tagatacaat ctacggtatc ccatcaggaa cactcagctc attgatggac   588660
gctttggctg aagacaaaga tatccgtttc ttacaagttc gccacgaaga gacaggtgct   588720
cttgcagcgg ttatgcaagc taaattcggc ggctcaatcg gggttgcagt tggttcaggt   588780
ggtccaggtg cgactcactt gattaacggt gtttacgatg cagctatgga taacactcca   588840
ttcctagcga tccttggatc acgtccagtt aacgaattga acatggatgc tttccaagag   588900
cttaaccaaa acccaatgta caacggtatc gctgtttaca acaaacgtgt agcttacgct   588960
gagcaattgc caaaagtaat tgacgaagcc tgccgtgctg cagtttctaa aaaaggtcca   589020
gctgttgttg aaattccagt aaacttcggt ttccaagaaa tcgatgaaaa ctcatactac   589080
ggttcaggtt catacgaacg ctcattcatc gctcctgctt tgaacgaagt tgaaatcgac   589140
aaagctgttg aaatcttgaa caatgctgaa cgcccagtta tctatgctgg atttggtggt   589200
gttaaagctg gtgaagtgat tactgaattg tcacgtaaaa tcaaagcacc aatcatcaca   589260
actggtaaaa actttgaagc tttcgaatgg aactatgaag gtttgacagg ttctgcttac   589320
cgtgttggtt ggaaaccagc caacgaagtg gtctttgaag cagacacagt tcttttcctt   589380
ggttcaaact tcccatttgc tgaagtttac gaagcattca agaacactga aaaattcatc   589440
caagtcgata tcgaccctta caaacttggt aaacgtcatg cccttgacgc ttcaatcctt   589500
ggtgatgctg gtcaagcagc taaagctatc cttgacaaag taaacccagt tgaatcaact   589560
ccatggtggc gtgcaaacgt taagaacaac caaaactggc gtgattacat gaacaaactc   589620
gaaggtaaaa ctgagggtga attgcaattg tatcaagttt acaatgcaat caacaaacat   589680
gctgatcaag acgctatcta ctcaatcgac gtaggtaaca ctactcaaac atctactcgt   589740
caccttcaca tgacacctaa gaacatgtgg cgtacatctc cactctttgc gacaatgggt   589800
attgcccttc ctggtggtat cgctgctaag aaagacaatc cagatcgcca agtatggaac   589860
atcatgggtg acggagcatt caacatgtgc tacccagacg ttatcacaaa cgttcaatac   589920
gaccttccag ttatcaacct tgtcttctca aatgctgagt acggcttcat caagaacaaa   589980
tacgaagata caaacaaaca cttgtttggt gtagacttca caaacgctga ctacgctaaa   590040
attgcggaag ctcaaggagc tgttggattc acagttgacc gtatcgaaga catcgatgca   590100
gttgttgcag aagctgttaa attgaacaaa gaaggtaaaa ctgttgtcat cgatgctcgc   590160
atcactcaac accgtccact tccagtagaa gtacttgaat tggatccaaa acttcactca   590220
gaagaagcta tcaaagcctt caaggaaaaa tacgaagcag aagaactcgt accattccgt   590280
ctcttcttgg aagaagaagg attgcaatca cgcgcaatta aataattcct ctcgccgaaa   590340
atcaaatatg aaacttgtag actttattct ttgattttca tagagcagaa ctttaaaaga   590400
tcggagcaat ccggtctttt tatggaggag agtaaatgaa tttaaatcaa ttagatatta   590460
tcgtttcaaa tgttccccaa gtctgtgctg acttggagca tatcttggat aaaaaggcag   590520
attatgctaa tgatggtttt gctcagttta cgattggtag tcactgcctt atgttgtcac   590580
aaaatcattt ggttcctttg gaaaactttc agtcaggaat cattattcat atcgaggttg   590640
aggatgtaga ccagaactac aaacggttga acgagcttgg tataaaggtt ttacacggac   590700
caactgtaac cgattgggga acagagtcct tattagttca aggacctgct ggtctagtgc   590760
ttgattttta tcgtatgaaa taggtcgcgt agtcatttga cgttaacctt agctattttt   590820
aaaatagaaa ttgagaatat gaactattga aagatcggag caatccggtc tttttatata   590880
aagaaattgc atataatact catctgcttt caaaaagcat tctagtccat ctccgattaa   590940
cgatggactt tatcacctcc ttctccaatc cttgtatgac atcttggagt tgattcatga   591000
catcttccaa aattcgaaag gctttattct taaatccacg tttacgaatc tctttccaca   591060
cttgttcaat ggggttcatc tctggtgtgt atggaggaat aaatgcaaaa ccaatattag   591120
tcggaatctt taaggtactt gatttatgcc atatagcatt gtccataacg agtaaaagga   591180
taagcttgtg aaagctcttc taaaaaggcg ttcatccact cagtattaca tctaccagct   591240
attaagaaaa atgattcgcc tgtataggca tcaacagctc cataacaata gcgaaattct   591300
cgtatatagt gactatggat atgtggacct actcctattg gagcccaaca agatcccagt   591360
ttactgattc taccgaaacc agcttcagct tggtacatca agcaaacctt acgaaaacgt   591420
ctactatatt taaaacgctt tcttgccttc ttggattgag attttatttt tagacgcaac   591480
aatggtttga gcgtctgctt tcttaggatg ttctggacgt ggcgtaatat ttcgccaacc   591540
atggcgcttc aacagttgat agaaggcatc acgtgtgtag gaacgaccta actccttttt   591600
ataagcctga aataaggcat caattgtaac aaattctcct gcctctgtag ccttcaaatg   591660
gcgggcaaga aaggctttct cttcctcaac tgtcatatat gcatggttac gaccaccacg   591720
tgtttcttga aggagagagt cgagtccgaa ctcctcatat ttttttacat ttcgccaaat   591780
cgttgtttga ttacagtcta tagtgtattg aatctataac agtacacctt ggctgctaaa   591840
atatttctat aaattaattt gactttcctg atagagttgt tcacatctta tttcaaacta   591900
ctataaaagt tctataatct ctttataaga tttgcccatc agacgaaata tagtagattg   591960
aaactagaat agtacacccc tacttctaaa acattgttag aaatcgattt gactgtcctg   592020
atcgatttgt actgttctta tttcatttta ctatagaacg atttgaaggc gtttatgata   592080
tttagctgta cgagagtctt ttaaaagtgt tttgatggtt tggatttctt ctttagttga   592140
tttcatatca ctattatata atgctttttg attttagttt agtattatcg tagaaaatgg   592200
actcggtgct atggatacac cggatgagaa tggttatgta gcagatgact atcggattac   592260
ttacttagag gcccacatca aggccatgcg agatgccatt taccaagacg gggttgactt   592320
gcttggttat acgacttggg gctgtatcga tccggtttca gctggcacag gggaaatgaa   592380
taagcgctat ggctttatct atgtagatcg agataatgta ggaaacggag ctctcaaacg   592440
tagcaagaag aagtccttct attggtacaa ggatgtcatt tatagcaatg gtgcaagcat   592500
cgggtagagc acatttgttt actattttta taaaatcttc tccctgcttt ataagatgta   592560
aaaaagagtt caattcgaac tctttttttg ctataatgag gggagaaaaa tcagacagga   592620
gatcgacatg tcagaaccat tatttttaca atcagttatg caagaaaaaa tctggggtgg   592680
agccaagcta cgtgatgagt ttggctacga catcccaagt gaaaaaatcg gagaatattg   592740
ggccatctca gcccatccaa atggagtctc taaagttgcc aatggtcgtt acgagggaac   592800
agatcttgct actttgtatg cggaacaccg tgaattattt ggcaatcgtc cagaacctgt   592860
atttccactt ttgaccaaga tcctcgatgc caacgactgg ctcagtgtcc aagttcaccc   592920
agacgatgct tatggactcg agcatgaagg cgaactcgga aaaacagaat gctggtacat   592980
tatcgcagcg gatgaaggtt cagagattat ctacggtcac aatgccaagt caaaagaaga   593040
actccgccag caaatcgagg acaagaactg ggatgacttg ttgaccaaag tccctgttaa   593100
ggctggagat ttcttctatg taccaagcgg gactatgcac gctatcgggg cgggtatctt   593160
aatccttgaa acccagcagt ctagcgatac cacctatcgc gtctatgact ttgaccgcaa   593220
ggatgacaaa ggcaacttgc gtgaacttca tcttgaaaaa tccatcgatg tcttgaacat   593280
tggtgagcca gcaaatagcc gtcctgtaac tgttaaagca gatgatttgc gttccactct   593340
ccttgtatct aatgatttct tcgcagttta caagtgggaa attactggaa aagttgactt   593400
tgaaaagaca gctgactaca gcttattgag tgtcttggct ggtcaaggtc agctaactgt   593460
tgacgggaaa aattatccaa ttcaaaaagg cagccacttt atcctaccaa gtgatgttga   593520
agcttggact ctggaagggc aaggtttgga attgattgtt agccatccat aaaaagaaag   593580
ggcctgagtt cactactcaa gtcctttttg attacataaa ttgggcaatg aagaccacaa   593640
tgatgatgat tggaatgacg aaacgaagaa acgaagaagg aagagccaga cttggaacag   593700
tccttgtttc catgctcttt catcgagatg gagttcctcc attgcaagag cctttttaaa   593760
gatatagcct gtaaaaagtg aaaggtagag agctccaaat ggcatgagga gattggaaac   593820
caagaagtcc atagcgtcaa agaaggtctt accaaaaatg tgaacatccg ccatgacacc   593880
gtaagatagg gctgaaggaa tgccaaagac aaaggtcaaa attcctaaaa taacactcca   593940
tttggcacgt ttgctgttat cctggttggt gatattgtct acattgattt ccagcatcac   594000
gacagaaaaa gtgactgtcg caaaaaggaa gagcaagagg aagaggacgt agaaaatggt   594060
tccaaaaggc atcttgtcaa agagttgagg caagacgata aagagcaggc tgggtccccc   594120
ttcagactgg atattgaagg gggatcgagc ttggaaaatg gctagacctg ccatgatgga   594180
tatcgagata ttcatggcta cgatggagat tcctgactgg actagattgg ttttcttgtc   594240
taagtaagaa gcataggtca acatgactgt aacccctagt gagagggcaa agaaagattg   594300
tcccagagca tagaggagac cagtgctagt cagttttgaa aagtctggtt tgaggaagta   594360
aagaacccct tccatggcat ttggcaaact gagagagcga ccgatgataa aaacaaagac   594420
gataaagagc aggggcatca tgactttcga agctctttca atcccttttt gaaccccacg   594480
tgatacaatg aagatattca ataggataaa ggccgcttga gctcctaggg caatggctgg   594540
atttgaaatg attgaagtaa ataactgagc ataatcaccc gttccaccaa gttggaacaa   594600
tttcccaaac tcaataccta gatagactag aatccatcct ccgataacac tgtaaaaaga   594660
taagaggata aagagggcaa aggcgccaat ccaaccgata aagttgtact tgttattctt   594720
gcccagtttt ccaaaggttt tgatagcgga aacgccagca ctacggccaa gggcaaactc   594780
agccagcagg agagggaaac cgattaaaat agtggaaatg agaaagatta gtaaaaagcc   594840
tccaccgcca ttagcagcag tcatgtaggg aaacttccaa acggaaccaa gcccgatggc   594900
cagccagcag atgctagaat aaaaccaagt ttcgaccccc attgtgattt ttctgacata   594960
gttaaactct gatctccttt ttcaaaataa gaaaaagcta cttgagttgt caaatagcct   595020
tctgtttgat tgatagactt gactatccta tcatgttttc taaggtctgt caagaaaatc   595080
attttcaagt tttcacacct ttctcaaaaa agttaaaaaa ttttctcaaa aacgcttgac   595140
tctgacctaa ggcgaggggt tatactatca ttgtaaggag gaaatcatgt accatataaa   595200
agaagctgcg cagctttcag gtgtctctgt caagaccctg catcactatg acaagatagg   595260
actcttggtc cccttaaagt cggaaaacgg ctatcgaacc tacagtcaag aggatttgga   595320
acgccttcag gtcattcttt actacaaata tctaggcttt tctttagaga aaatagcaga   595380
gctgttaaag gaagaaagga cagatttatt gccccatttg actaggcagt tggactatct   595440
aactcgcgaa aggcaacatc tggatacctt gatttccacc ttgcaaaaaa ctattcaaga   595500
acaaaaagga gaaagaaaaa tgaccattga ggaaaaattc acgggattta gctatcaaga   595560
caatcaaaaa taccaccaag aagcggtaga gaaatatggt caagaagtca tgggacaagc   595620
gctcgaacgc caaaaaggtc acgaagacga ggctacggcc gcctttaacc aagtctttca   595680
aactttggca caaaatcttc aagttggttt acctgcaaca gcaaccgaaa accaggagca   595740
agcagccaag ctcttgcaag ccattcgcac ttatggattt gactgctcta ttgaggtatt   595800
cggtcatatc ggtaaaggtt acgtctacaa cccagagttt aaggaaaaca ttgacaagtt   595860
tggttctgaa acagcccagt acacgtcaga tgccattgcg gtttacgttc agacaaatgc   595920
agaataaata ggctaggaat ttcctagcct attttttact tcaaatcata aagccagtcg   595980
tcaccgtttt tgtagtaaaa gaattcactg agatcttctt ctagaaacac acgaagcata   596040
tcagacatat catcggttgc aagttttaga tgagaaagat tttcaaagtc ctcccaccaa   596100
actttccctt cgtctgaaga ctggagttca ccagtaaagt gttctgtctt gtaaaaaagg   596160
acgacataac gataatcctt gtcgtcatac cagtttttga taccacagag ttggggtttg   596220
gaaatgatca gaccagtttc ttctttcact tcacgaatga cagcatcgac aaaggattcg   596280
ccacgttcaa catgaccacc aggaaaagta atgccagacc agtcgggatt aactcggtct   596340
tggaccagga ccttatctcc gtttttaatc atacacatgt taacaaattc gactgcctct   596400
cttctgttca ttcttcacaa cctttaatct ttaatcataa tgcagacttc ccgccaccca   596460
gccggtacag agggcagaag tgatgttaaa gccacccgtg tgggcattga tatccataac   596520
ttcgcctgca aagtggaggc caggtaccag cttactttca agggttttag gattgatttc   596580
cttgagactg actccaccct tggtaacaaa ggactttgca agggacattt ttccagttac   596640
aggaatttta agttctttaa tggactggac aagttgttct cgttcctttt cagtcagttg   596700
tttgactttt tcaggatatc cttgtacaaa aaattcggcc aagcgttctg gtaacaaggt   596760
ttttaaagcg tttttcaagg atttttcccg attttcttct agaaatgtaa ccaagtcctt   596820
ctcagaaagt tgaggcaaaa catcgagtga gagaacctcc ccacctttga caaagctaga   596880
catgcgtagg gcagcaggac ctgacaaacc aaagtgggta aagagtaaat catgagtgat   596940
gacatgctta ccataactta gggtcacatc gtccagagaa ataccttgta aggctttatg   597000
tggaaaatct gttaataaag gactttcagc agcctcaaga tcggtgatgg tatgcttaaa   597060
atggcgagca atctcgtgac caaaaccagt cgaaccagtc gaaggataag acttaccacc   597120
tgttgtgaca atgagtttct cacaagtgaa ggtttgatcc gctgacttaa ggacaaactg   597180
gtcatctact tttttaacag aaacgatttc tatttgagta gcaacttgac cacctagttc   597240
ggtgattttc ttttccaaag cttcgataat agtccgagac ttgtcactgg ctggaaagac   597300
gcgtccgtgg tcttcgacct taagtttaac accattttct gtaaaaaagt tgatgatgtc   597360
atgattatcg aactgggaga aaacactgta aagaaagcgt ccgtttccag gaattccagc   597420
tagcaggttg tctaagctac cattgttggt cacattgcaa cgtcccccac cagtcccagc   597480
taattttttt ccaagtttcc gatttttttc gatgaggagg gttttctgtc cataaaagct   597540
actggaaatc gtagccatca taccagcagg tcccccaccg atgacaatag tatcaaaatg   597600
tttcatagct ctattgtacc acaaaaaaac aagagatgat ggtcacctct tgtcaagaat   597660
gcaattaatc aatttcatag cccatcagca aaccgccctc ttctgcatag aaactgcaga   597720
gaccagaggt tggtagaatt ttaatatccg cttgtgggaa ggtttcacgg attcgctctg   597780
agagctgttg acaacatttt tcgttattgc gttgggccat gacaatacgg ccaccagcat   597840
atccagcttt tactaactca tcataggcag cttgaactga tttctttgat ccccttgctt   597900
tttgtagcaa ttcgagagtc ccagtttcac tagcttttcc gaccatacga atgttgagaa   597960
ggccaacgac cgtaccgata agcttgctca aacggccgtt cttcaccaag ttatcgactt   598020
tggctaggac aaagagcaac ttagtttttt cttgataggc ggtgatagct tcaaccactt   598080
cttcaaaaga caagccctgg tcaatcaagt cattcaattt ttctacgagt aggtcaactt   598140
caccaccagc agataaacta tcaatcacat gaatcttagt gtcaggatgg tcttccagat   598200
aaatattctt tgctagttga gcactattgt gactgccaga aagggtacct gtgatggtta   598260
ctaggaaaat gtttttggca ccttcaaatg ctcgcaaata gtcatctggg cttggacaag   598320
ccgattttga agcttctgca gttgcataca tggtttccat catttggtca atatcgagac   598380
tggcgtcatc aacaaagacc tgatcagcta cttgaatggt taaggggaca cttacaaagg   598440
ttgtgttaat agctggtgtt ggcagttgac gataatcaca accagagtca gcaataatct   598500
tccaagtcat agaaattctc catctttgtc agttatacat tgacaaaggt tctgtctttt   598560
tttacaatta tatcatgaaa acccttgaaa caaaagcatc atccgtctgt tgtgacaagt   598620
agaaagaaaa tgttatgtct gaacgtagaa tctctgaaaa gtctcttgaa aatctcagaa   598680
aatcaaacca agaatccaat ttattaacca gagaagccat tgaaacagcc ctcttgcaac   598740
tcttggaaaa aaaggaactg accaagatta gtatttctga attggtcaaa cgtgcaggtg   598800
tttcgcgtgc ggccttttat cgcaattatg actccaaaga ggaaatttta gagagcgtct   598860
ttaaacgaac tgtccacaat attatggaac agctgcatca ttacgattta aagacagacc   598920
tttatttggt ttgggttcac cttttccggg aggccagaaa ggaagctaga gtaattcaat   598980
tggccttgga ttaccatctg gaaaaaatct ttgtccaagc catgcaggaa tttctagaaa   599040
aataccatgg gaaatcaaaa ggtgtcagct cttatcttca ttccttctgg agctcagcca   599100
tcgtctctgt ccttctaaaa tggatcaagg atggcatgaa ggtaccagct gaaaagattg   599160
cagatttagg tttaccattt tttaaaaaat agagaaaaag gagaaaagag atgactgaaa   599220
aaagactggc ctgggatgag tattttgcag cccaagctct actaattgcg aatcgttcca   599280
cttgtaaacg tgctaaagtg ggcgcgattc tggtaaaaga taataaggtt atttccactg   599340
gttacaatgg ttcggtgtca gggactgagc attgtattga tcacgaatgt ttggtcattg   599400
aaggccactg cgttcgcacc cttcacgctg aggtcaatgc tatccttcaa ggtgctgagc   599460
gtggtgttcc caaaggcttt acagcctatg taacccattt tccttgtctc aactgtacaa   599520
aacaattgct tcaggtcggc tgcaagcgcg tggtttatat caaccagtac cgaatggacg   599580
actacgccca atacctttat caagaaaaag ggacagaatt gacccattta ccacttgaga   599640
cagtacagac agctcttaaa gaggctgatc taatgtaaaa attatcaaaa ataaatggtt   599700
tagaaagatt tttaaaccgt tttttggtat aataagaaga ataaattgaa agaaggaatt   599760
ccaaaaatgg gaaaaattga agttattaat cacccactga ttcaacacaa attgtcaatc   599820
ttgcgtcgta cagatacttc tacaaaagct tttcgtgagc tagtagatga gattgcaatg   599880
ttgatggggt atgaagtact tcgtgatctt ccactagaag atgtggaaat cgaaacacca   599940
attacaaaaa cagttcaaaa acaattggca ggtaagaaat tggccatcgt cccaatcttg   600000
cgtgcaggta tcgggatggt tgatggtctc ttgaacttgg ttccagctgc taaagttggc   600060
cacatcggta tgtaccgtga tgaagaaaca cttcaaccag ttgaatactt ggtgaaattg   600120
cctgaggaca ttgaccaacg tcaaattttt gtagtagacc caatgttggc aacaggtggc   600180
tcagcaatct tggctgttga ttctcttaaa aaacgtggcg catcaaatat caaatttgtc   600240
tgccttgtat ctgctccaga gggtgtaaaa gcccttcaag aagctcatcc agatgtagaa   600300
atctttacag cagccttgga tgaacgtttg aacgaacacg gttatatcgt tccaggtctt   600360
ggagatgctg gagaccgctt gttcggtaca aaataagatc gaaaagaaga atgacttgga   600420
aaagtatttc cagtcacgaa aggaggttgg gtttttgttt ctgtctaatg aaagcagagc   600480
aaaaatttga ccttttttga ccaagatatt ataatagtct tatcttcagt catttgacca   600540
acaaaattaa aactcaaaag gagaaatgaa tgattcctgt agttattgaa caaacaagcc   600600
gtggagaacg ttcttacgat atttactcac gtcttctcaa agaccgcatc attatgctga   600660
caggtccggt tgaagacaat atggctaact ctgttattgc ccaattgctt ttcttggatg   600720
cccaagatag tacaaaagat atttaccttt atgtcaatac accaggtggt tctgtttcag   600780
ctggtttggc aatcgtagat accatgaact ttatcaaggc agatgtccaa accattgtta   600840
tgggaatggc tgcatctatg gggactgtca tcgcatcaag tggagcaaaa ggcaaacgtt   600900
tcatgcttcc aaatgctgaa tacatgattc accaaccaat gggtggtaca ggtggtggta   600960
cccaacaaac tgatatggct atcgctgcag aacacttgct caaaactcgt aataccttgg   601020
aaaaaatctt ggctgaaaat tcaggtcagt caatggaaaa agtccatgca gatgcagaac   601080
gtgataactg gatgagcgcc caggaaacac ttgaatatgg ctttattgat gaaattatgg   601140
ccaacaattc attgaactaa tgatgataga aggcaaactc gactgggttt gctttttttg   601200
gtataatagg gagagatttc ttagaaagag gatttatcat gtttgaaaaa gtcaatcgct   601260
ctggcttgat tatctatctt tactataatc gtgatgccaa aaaactgcag gattatggag   601320
atattaccta tcattccaag aaacatcgtt acttacaact ctatgttcca actcaagaag   601380
tggagcaatt ggtcggacgc ttgagcaagg aaaaatttat taaaaaagtt agggtttgtc   601440
atatccaaga gttggaaaca ccctttgtgg gcaatcttta tcgataggaa aacgttatca   601500
tcgaaaaagt tcaaggaaaa cattgacaat tttctgataa ttcggtatat tcttaacaga   601560
ctatttaaga aataaggaga caaaaagatg aagaaaaaat ttgccctatc gtttgtggcg   601620
cttgcaagtg tagcacttct tgcagcctgt ggagaagtga agtctggagc agtcaacact   601680
gctggtaact cagtagagga aaagacaatt aaaatcgggt ttaactttga agaatcaggt   601740
tctttagctg catacggaac agctgaacaa aaaggtgccc aattggctgt tgatgaaatc   601800
aatgccgcag tggtatcgat ggaaaacaaa tcgaagtagt cgataaagat aataagtctg   601860
aaacagctga ggctgcttca gttacaacta accttgtaac ccaatctaaa gtatcagcag   601920
tcgtaggacc tgcgacatct ggtgcgactg cagctgcggt agcgaacgct acaaaagcag   601980
gtgttccatt gatctcacca agtgcgactc aagatggatt gactaaaggt caagattacc   602040
tctttattgg aactttccaa gatagcttcc aaggaaaaat tatctcaaac tatgtttctg   602100
aaaaattaaa tgctaagaaa gttgttcttt acactgacaa tgccagtgac tatgctaaag   602160
ggattgcaaa atctttccgc gagtcataca agggtgaaat cgttgcagat gaaactttcg   602220
tagcaggtga cacagacttc caagcagccc ttacaaaaat gaaagggaaa gactttgatg   602280
ctatcgttgt tcctggttac tataatgagg ctggtaaaat tgtaaaccaa gcgcgtggca   602340
tgggaattga caaaccaatc gttggtggtg atggattcaa cggtgaggag tttgtacaac   602400
aagcaactgc tgaaaaagca tcaaacatct actttatctc aggcttctca actactgtag   602460
aagtttcagc taaagctaaa gccttccttg acgcttaccg tgctaagtac aatgaagagc   602520
cttcaacatt tgcagccttg gcttatgatt cagttcacct tgtagcaaac gcagcaaaag   602580
gtgctaaaaa ttcaggtgaa atcaagaata accttgctaa aacaaaagat tttgaaggtg   602640
taactggtca aacaagcttc gatgcagacc acaacacagt caaaactgct tacatgatga   602700
ccatgaacaa tggtaaagtt gaagcagcag aagttgtaaa accataatag aaaaatgttg   602760
aaatagggaa tgagcctttg actcactccc tgtttcgata tttaatactc ttcgaaaatc   602820
tcttcaaact gcgtcaacgt cgccttggat tatatatgtg actgacttcg tcagtcttat   602880
ctacaacctc aaagcagtgc tttgagcaac ctgcggctag tttcctagtt tgctctttga   602940
ttttcattga gtataagaac ctatcaaaaa gtgagggaaa accctcggaa ttataaatag   603000
aaagagtgaa tcttatgctc caacaactcg taaatggttt gattctaggt agtgtttacg   603060
cgctgttagc cctaggatat accatggttt acggaattat caagctcatc aacttcgccc   603120
atggtgatat ttatatgatg ggagccttta tcggttattt cttgatcaat tctttccaaa   603180
tgaatttctt tgtagcgctt attgtagcta tgctagcgac agctattctt ggtgtcgtga   603240
ttgagtttct tgcttaccga cctttgcgcc actctactcg tattgctgtt ttgattacgg   603300
ctattggggt ttctttccta ttggagtatg gaatggtcta tctggttggt gccaataccc   603360
gtgccttccc tcaagcgatt caaacagttc gatatgattt gggaccaatt agcttaacaa   603420
atgtgcagtt aatgattttg gccatttcct tgattttgat gattttgtta caagtcattg   603480
tccaaaagac taagatgggg aaagccatgc gtgcagtatc agtagatagc gacgcggcgc   603540
aattgatggg gatcaatgta aaccgtacga ttagctttac cttcgctttg ggttctgctc   603600
ttgcgggtgc ggctggtgtt ctgattgctc tttattataa ctctcttgag cctttgatgg   603660
gggttactcc aggtcttaaa tctttcgttg ccgcagtact tggtggtatc ggaattattc   603720
ctggtgcggc tcttggtggc tttgtgattg gtctattgga aacctttgcg actgcctttg   603780
ggatgtcaga tttccgtgat gccattgttt atggaatctt gttgttgatc ttgattgtcc   603840
gcccagctgg tatccttggt aagaatgtga aagagaaggt gtaaacgatg aaggaaaatt   603900
taaaagttaa tattctatgg ttactccttt tgttagctgg ctatagcttg attagtgtac   603960
tggtttcagt cggagtactt aatctattct atgtacagat tttacaacaa attggaatta   604020
atattatttt ggctgttggt ctcaacttaa tcgttggttt ttcaggacaa ttttcacttg   604080
gtcatgctgg tttcatggcg attggtgcct atgcagcagc tattattggt tctaaatcac   604140
caacctacgg tgccttcttt ggagctatgc ttgtaggggc tttgctttca ggagcagttg   604200
ccttacttgt cggcattcca accttgcgct tgaaggggga ctatcttgcg gtagcaactc   604260
tgggtgtttc tgaaattatc cgtatcttta tcatcaatgg tggaagcctt acaaatggtg   604320
cggcaggtat cttagggatt cctaacttta caacttggca aatggtttac ttctttgtcg   604380
tgattacaac cattgcaacc ttgaacttct tgcgtagccc aattggtcgt tcaaccctct   604440
ctgttcgtga agatgaaatc gctgctgagt cagttggggt taatacgact aaaattaaaa   604500
tcatcgcttt tgtctttggt gccattactg caagtattgc tgggtcactt caggcaggat   604560
ttatcgggtc tgttgtaccg aaagattaca ccttcatcaa ctcaatcaac gttttgatta   604620
ttgttgtatt tggtggactc ggttccatta caggtgcgat tgtttcggct attgttctgg   604680
gaattttgaa tatgcttctc caagatgttg ctagtgtgcg tatgattatt tacgctttgg   604740
ccttggtatt ggtaatgatt ttcagaccag gtggactcct tggaacatgg gaactgagcc   604800
tatcacgttt ctttaaaaaa tctaagaagg aggaacaaaa ctaatggcat tacttgaagt   604860
aaaacagtta accaaacatt ttggtggtct aacagctgtt ggagatgtga ctcttgaatt   604920
gaacgaaggg gaactggttg gattaatcgg tccaaacgga gctgggaaaa ccaccctttt   604980
caaccttttg accggtgttt atgaaccaag cgagggaaca gtaaccctag atggtcacct   605040
tttgaatggg aaatcacctt ataagattgc ctctttggga cttggacgta ctttccaaaa   605100
tatccgtctc tttaaagatt taacagtttt agataatgtt ttgattgctt ttggaaacca   605160
tcacaaacag catgttttta ctagtttctt acgcttacca gctttttaca agagtgaaaa   605220
agaattaaag gctaaagctt tggaattgtt gaaaatcttt gatttagatg gtgatgcaga   605280
gactcttgct aaaaatcttt cctacggaca acaacgtcgt ttggaaattg ttcgtgccct   605340
tgctacggaa cctaaaattc tcttcttaga tgaaccagca gcaggtatga acccacagga   605400
aacagccgaa ttgactgagt taattcgtcg tatcaaagat gagtttaaga ttacaatcat   605460
gttgattgaa cacgatatga atctggtcat ggaagtaaca gaacgtatct acgtacttga   605520
atatggccgt ttaatcgctc aaggaactcc agacgaaatt aagaccaata aacgcgttat   605580
cgaagcttat ctaggaggtg aagcctaatg tctatgttaa aagttgaaaa tctttctgtg   605640
cattacggta tgatccaagc agttcgtgat gtaagctttg aagttaatga aggagaagtt   605700
gtttccctta tcggtgccaa cggtgcaggt aagacaacta ttcttcgcac cttgtcaggt   605760
ttggttcgac caagttcagg aaagattgaa tttttaggtc aagaaatcca aaaaatgcca   605820
gctcagaaaa tcgtggcaag tggtctttca caagttccag aaggacgcca cgtctttcct   605880
ggcttgactg ttatggaaaa tcttgaaatg ggagctttct taaagaaaaa tcgtgaagaa   605940
aatcaagcta acttgaagaa ggttttctca cgctttcctc gtcttgaaga acggaagaac   606000
caagatgcag ccactctttc agggggggaa caacaaatgc ttgccatggg acgcgccctc   606060
atgtcaacac caaaacttct tcttttagat gaaccatcaa tgggacttgc cccaatcttt   606120
atccaagaaa tttttgatat cattcaagat attcagaagc aaggaacaac ggtcctcttg   606180
attgaacaaa atgccaataa agcacttgca atctctgacc gaggatatgt actggaaaca   606240
gggagaatcg tcctatcagg aacaggaaaa gaactcgctt catcagaaga agtcagaaaa   606300
gcatatctag gtggctaaaa caatccagtg gattgtttta gtcggcagat ggagattacg   606360
aagtaatcat caatatagtc cgggggacct ttttagtcgg tagattgaga ttgcaaacaa   606420
atctgcatct acattgaaag cttaatttct aataattgaa aaaatcgaat gaaaaatttc   606480
ttaccttcat tcacagagct cgatttcaga gctctttttg ctagcttatt catacttttc   606540
tgaatttcga aaaagaaatg taagcgtttg atagatttac aaaaagattg tataataggg   606600
ataagaatag aaaaggagaa gtctcatggc agttaaagat tttatgaccc gcaaggtagt   606660
ttatattagt ccagatataa cagtatctca tgcagcagat ttgatgagag agcaaggttt   606720
gcaccgtctg cctgttatcg aaaatgatca attagttggt ttggtgactg agggaaccat   606780
tgcacaagca agtccatcta aagcaacaag tctttctatc tatgagatga attatcttct   606840
gaataagaca aaagtaaaag atgtcatgat tcgcgatgtt gtcactgtct caggctatgc   606900
tagtctagaa gatgcaactt atctgatgtt gaaaaataag attagtattc tccctgtcgt   606960
agataaccat caagtatacg gagttattac tgaccgtgac gttttccaag cctttcttga   607020
aattgcaggt tatggcgaag aagggattcg tgtacgcttt gttacagaag atgaagttgg   607080
tgttcttgga aaaattgttt ctttgattgt agaagaaaat ttgaatatct cccatacagt   607140
caatattccg cgtaaggatg gtaaggtgat tatcgaagtg caaatcgatg gatcaattga   607200
tttaccagcc ttgaaagaaa aatttgaagc aaatggtatt caagtggaag aaatcgctcg   607260
cacttcagca aaagtcttgt aagaagggaa gcccaaaggc ttcttttttc atgaaaaggg   607320
gattagagca aaagatggaa agaaatgata aaatatgcta taatgaaata atgtaaaaaa   607380
ggagtattta tggacatttc agtaattcgt cagaaaattg acgcaaatcg tgaaaaatta   607440
gcttctttca gggggtctct ttgacctcga agggctagag gaagagattg ccatcttgga   607500
aaacaagatg acagaacctg atttttggaa cgataatatt gcggcccaaa aaacgtcgca   607560
agaattaaat gaattaaaaa acacttacaa taccttccat aagatggaag agttgcagga   607620
tgaagtcgaa attttattgg attttttggc tgaagacgag tcagtgcatg atgaactggt   607680
agcgcagtta gccgaacttg ataagataat gaccagctac gagatgactc tactcttgtc   607740
agaaccttat gaccacaaca atgccatctt ggaaatccat ccaggttctg gtggtactga   607800
ggcgcaggac tggggtgata tgttgcttcg tatgtatact cgttatggta atgctaaagg   607860
ctttaaagtg gaagtgttgg attaccaagc aggtgatgag gctggtatta agtcggtaac   607920
tttatcattt gaagggccta atgcctatgg tctcctcaag tcagaaatgg gtgttcaccg   607980
cttagtgcga atctcaccat ttgactctgc caaacgtcgc catacctctt tcacatctgt   608040
agaagtgatg ccagaattgg atgatactat tgaagtggaa atccgtgaag atgatatcaa   608100
gatggatacc ttccgttcag gtggtgccgg tggacaaaac gtcaataagg tttcaacagg   608160
tgtacgttta acccacattc caactggaat tgttgtccaa tcaacagtag atcgtaccca   608220
gtatggaaat agagatcgtg ccatgaagat gttgcaggct aagctctatc aaatggagca   608280
agataagaag gctgcggagg tagattctct caaaggtgag aaaaaggaga tcacttgggg   608340
aagccaaatc cgttcttatg tcttcacgcc ttatactatg gtaaaagatc accgaactag   608400
ctttgaggtt gctcaggtag ataaggttat ggatggggac ctagatggtt ttatcgatgc   608460
ttatctcaag tggcgaatta gctaagatag aaaggaactc acatgtcaat tattgaaatg   608520
agagatgtcg ttaaaaaata cgacaacgga acaactgctc tacgcggtgt ttcggttagc   608580
gttcaaccgg gggaatttgc ttacatcgta ggaccttcag gagcagggaa gtcaactttt   608640
attcgttctc tgtatcgtga agtaaaaatc gataaaggaa gcctatcagt tgctggtttt   608700
aatctggtta agatcaaaaa gaaagatgtc ccgcttctac gtcgtagtgt tggggttgtc   608760
ttccaggatt ataaattgtt accaaagaaa actgtctatg aaaatattgc ttacgctatg   608820
gaagtaatcg gggaaaatcg ccgtaatatc aaaagacgag tgatggaagt tttggacttg   608880
gttggattga agcataaggt tcgttctttc ccaaatgaac tctcaggtgg ggagcaacag   608940
cggattgcga ttgcgcgtgc aattgtaaat aatcccaaag tattgatagc tgatgagcca   609000
acaggaaatc tggatccgga taattcatgg gaaattatga atctcttgga acggattaac   609060
ctacaaggaa caactatttt gatggcgact cataatagcc agattgtaaa taccttgcgc   609120
caccgtgtca ttgccattga aaatggccgt gtcgttcgtg acgaatcaaa aggagagtat   609180
ggatacgatg attagtagat tttttcgcca tttatttgaa gccttaaaaa gtttgaaacg   609240
aaatggttgg atgacagtag ctgctgtcag ttcagtcatg attactttga ccttggtggc   609300
aatatttgca tctgttattt tcaatacagc gaaactagct acagatattg aaaataatgt   609360
ccgtgtagta gtttatatcc gaaaggatgt ggaagataat agtcagacaa ttgaaaaaga   609420
aggtcaaact gttacaaata atgactacca caaggtatat gattctttga agaacatgtc   609480
tacggttaaa agtgttacct tttcaagtaa agaagaacaa tatgaaaaat taaccgagat   609540
aatgggagat aactggaaaa tctttgaagg agatgccaat cctctctatg atgcctatat   609600
tgtagaggca aacactccaa atgatgtaaa aactatagcc gaagatgcta aaaaaattga   609660
aggtgtctct gaggttcaag atggcggtgc caatacagaa agactcttca agttagcttc   609720
atttatccgt gtttggggac tagggattgc tgctttgtta atttttatcg cagttttctt   609780
gatttcaaat accattcgta ttaccattat ttcccgcagt cgcgaaattc aaatcatgcg   609840
cttggtcgga gctaaaaaca gttatatccg tggaccgttc ttgttagaag gagcctttat   609900
cggtttattg ggagctatcg caccatctgt tttggtcttt attgtttatc aaattgttta   609960
ccaatctgtc aacaaatcgt tggtagggca aaatctatcc atgattagtc cagatttatt   610020
tagtccgttg atgattgccc tactatttgt gattggggtt ttcattggtt cattgggatc   610080
aggaatatcc atgcgccgat tcttgaagat ttaggtaaaa tagctgcttt tatgaggaga   610140
ttgtaaaatc tccttttttg ctacaagagt ttttgaaaag agatgcgcag aagaaaagag   610200
cttccaaaga agtcccccag agaagacttc ttgatggcta atttgaactt gaaatttggc   610260
gcactagaaa ttttttagaa aaaagtgtaa tttttttata aaagccttta caaaaaaaat   610320
taaagtggta taattaaatc atagaaagtg caaacgtttt cgtaaaacgt ttgcctaaat   610380
aaaaataaag gagatttgaa tgatgaaaga tacattcaaa aatgtcttgt ctttcgaatt   610440
ttggcaaaaa ttcggtaagg ctttgatggt agttatcgcg gttatgccgg ctgctggttt   610500
gatgatttca atcggtaagt ctatcgtgat gattaaccca acctttgcac cacttgtcat   610560
cacaggtgga attcttgagc aaatcggttg gggggttatc ggtaaccttc acattttgtt   610620
tgccctagcc attggaggaa gctgggctaa agaacgtgct ggtggtgctt tcgccgctgg   610680
tcttgccttc atcttgatta accgtatcac tggtacaatc tttggtgtat caggcgatat   610740
gttgaaaaat ccagatgcta tggtaactac tttctttggt ggttcaatca aagttgctga   610800
ttactttatc agtgttcttg aagctccagc cttgaacatg ggggtattcg tagggattat   610860
ctcaggtttt gtaggggcaa ctgcttacaa caaatactac aacttccgta aacttcctga   610920
tgcactttca ttcttcaacg ggaaacgttt cgtaccattt gtagttattc ttcgttcagc   610980
aatcgctgca attctacttg ctgctttctg gccagtagtt caaacaggta tcaataactt   611040
cggtatctgg attgccaact cacaagaaac tgctccaatt cttgcaccat tcttgtatgg   611100
tactttggaa cgtttgctct tgccatttgg tcttcaccac atgttgacta tcccaatgaa   611160
ctacacagct cttggtggta cttatgacat tttaactggt gcagctaaag gtactcaagt   611220
attcggtcaa gacccactat ggcttgcatg ggtaacagac cttgtaaacc ttaaaggtac   611280
tgatgctagt caatatcaac acttgttaga tacagtacat ccagctcgtt tcaaagttgg   611340
acaaatgatc ggttcattcg gtatcttgat gggtgtgatt gttgctatct accgtaatgt   611400
tgatgctgac aagaaacata aatacaaagg tatgatgatt gcaacagctc ttgcaacatt   611460
cttgacaggg gttactgaac caatcgaata catgttcatg ttcatcgcaa cacctatgta   611520
tcttgtttac tcacttgttc aaggtgctgc cttcgctatg gctgacgtcg taaacctacg   611580
tatgcactca ttcggttcaa tcgagttctt gactcgtaca cctattgcaa tcagtgctgg   611640
tattggtatg gatatcgtta acttcgtttg ggtaactgtt ctctttgctg taatcatgta   611700
ctttatcgca aacttcatga ttcaaaaatt caactacgca actccagggc gcaacggaaa   611760
ctacgaaact gctgaaggtt cagaagaaac cagcagcgaa gtgaaagttg cagcaggctc   611820
tcaagctgta aacattatca accttcttgg tggacgtgta aacatcgttg atgttgatgc   611880
atgtatgact cgtcttcgtg taactgttaa agatgcagat aaagtaggaa atgcagagca   611940
atggaaagca gaaggagcta tgggtcttgt catgaaagga caaggggttc aagctatcta   612000
cggtccaaaa gctgacattt tgaaatctga tatccaagat atccttgatt caggtgaaat   612060
cattcctgaa actcttccaa gccaaatgac tgaagcacaa caaaacactg ttcacttcaa   612120
agatcttact gaggaagttt actcagtagc agacggtcaa gttgttgctt tggaacaagt   612180
aaaggatcca gtatttgctc aaaaaatgat gggtgatgga tttgcagtag aacctgcaaa   612240
tggaaacatt gtatctccag tttcaggtac tgtgtcaagc atcttcccaa caaaacatgc   612300
ttttggtatt gtgacggaag caggtcttga agtattggtt cacattggtt tggacacagt   612360
aagtcttgaa ggtaaaccat ttacagttca tgttgctgaa ggacaaaaag ttgcagcagg   612420
agatctcctt gtcacagctg acttggatgc tatccgtgca gcaggacgtg aaacttcaac   612480
agtagttgtc ttcacaaatg gtgatgcaat taaatcagtt aagttagaaa aaacaggttc   612540
tcttgcagct aaaacagcag ttgctaaagt agaattgtaa tatacttgag gttggaagct   612600
gtattccaac ctcttatttt gggagaaaag aatgaaattt ttaacactca atactcacag   612660
ttggatggag aaagaagcag aggaaaaatt ccagattttg cttgaagata ttcttgaaaa   612720
ggactatgat ttgatttgtt ttcaagaaat caatcaggag atgacctcgt cagaggtgga   612780
ggttaatgac ctttatcaag ctttgccagc agctgagcct attcaccaag accattatgt   612840
tagactcttg gttgaaaagt tgtctgagca agggaaaaat tactactgga cctgggccta   612900
taaccatatc ggctataacc gctaccacga aggtgtggct atcttgtcta aaacacctat   612960
tgaagccaga gaaattttgg tttcagatgt ggatgatcca acagactatc atactcgccg   613020
tgttgcccta gctgaaactg tagtcgatgg caaggagcta gcagttgcca gtgttcatct   613080
ctcttggtgg gataaaggtt tccaagaaga atgggcacga tttgaggctg tcttgaaaaa   613140
attgaacaag ccacttttac tagctggaga tttcaacaat ccggctggac aggaaggtta   613200
ccaagctatt ttagctagtc cattaggctt acaagacgca tttgaagttg ctcaagagaa   613260
aagtggtagc tatactgttc cgcctgaaat tgatggctgg aaagggaaca ctgaacccct   613320
tcgaatcgat tatgtcttta ctaccaaaga gttagcggtg gaaaatttac atgtcgtatt   613380
tgatggtaac aagagtccac aagtgagtga tcactatggc ttgaatgcta tattaaactg   613440
gaaataataa ctgaaaagag gttggaacta taaaattcca gccttttctt actagagaag   613500
ctactggaaa tagcctaaat aagtgagact actgtaatgg aataaaatat ggtataattg   613560
ataaggtaga tagaatcgag gatgttatgt catttacgaa atttcaattt aaaaactata   613620
ttagagaagc cttgaaggag ttaaaattta caactccaac agaggtgcaa gacaagttga   613680
ttcctattgt tttggcaggt cgtgacctag taggagaatc aaaaacaggt tcaggtaaga   613740
ctcatacttt cttgttaccg attttccagc aattagatga agctagcgat agtgtacaag   613800
cagtgattac tgcaccgagt cgtgagttgg ctactcaaat ttaccaagta gcgcgtcaga   613860
tttcagctca ctcagatgtc gaagttcgtg tggttaatta tgtgggtggt acggataagg   613920
ctcgccagat tgagaaattg gcaagcaatc agcctcatat tgttattgga acaccaggcc   613980
gtatctacga cttggttaaa tctggtgatt tagctattca taaagccaag acatttgttg   614040
ttgatgaagc agatatgacc ttggatatgg gattcttgga aactgttgat aagattgctg   614100
gcagtcttcc aaaagacttg caattcatgg tcttctcagc gactatccca caaaaactgc   614160
aaccattctt gaaaaaatac ttatcaaatc ctgttatgga gaaaattaag accaaaacgg   614220
ttatttctga caccattgat aattggttga tttcgaccaa gggacatgat aagaatgctc   614280
aaatttacca gttgactcag ttgatgcagc cgtatttggc aatgattttt gttaacacta   614340
aaacgcgtgc tgatgaattg cattcatatc tgactgctca aggcttgaag gttgcaaaaa   614400
tccatggcga tattgcccct cgtgaacgca agcgaatcat gaatcaggtg caaaatctgg   614460
attttgagta tattgtcgca acagatttgg cagcgcgtgg gattgacatt gaaggtgtca   614520
gccatgtcat caatgatgcc attccgcaag acttatcttt ttttgttcat cgtgttggtc   614580
gtactggacg aaatggccta ccaggtacag ctattaccct ttatcagcca agtgatgact   614640
cggatatccg tgagttggag aaattgggaa tcaagtttag tcctaagatg gtcaaagacg   614700
gggaatttca agatacctat gaccgtgatc gtcgtgccaa ccgtgagaaa aaacaagata   614760
aacttgatat cgaaatgatt ggtttggtta aaaagaaaaa gaaaaaagtc aaaccgggtt   614820
ataagaagaa aattcaatgg gcggttgatg aaaagcgccg taaaaccaag cgtgctgaaa   614880
atcgcgctcg cggtcgtgca gagcgtaaag ctaaacgcca aacattttaa tagaaattgt   614940
tggagtattg agctccaact tttttattta tgagaacgaa ctatctaaac cgaaacacta   615000
cattaaagac tgcaaattgc gattaaaaat ggtataatga taaagttata tagtcccgat   615060
aagatggtag gtatttatta cgaagagttt tcctatcagt actttgtaac tctataacaa   615120
tattttttaa ggggggacat ttttatgtca gagcgtaaat tattcacgtc tgaatctgta   615180
tctgaggggc atccggataa gattgcagac caaatttcag atgcgatttt ggatgctatt   615240
ttagcaaagg atccagaggc gcacgttgct gctgaaacag ctgtatatac tggttctgtc   615300
cacgtttttg gtgaaatttc tacaaatgcc tatgtggata ttaaccgtgt ggttcgtgat   615360
accattgcag agattggtta taccaataca gaatatggat tttctgctga gacggtggga   615420
gtacacccat ctttggtgga acaatctcct gacatcgctc aaggtgttaa cgaagccttg   615480
gaggttcgtg gaaatgctga tcaagatcca ctggacttga ttggagcagg tgaccaaggg   615540
ctcatgtttg gatttgcagt agatgaaaca gaagagctta tgccattgcc aattgcactc   615600
agtcataaat tggttcgtcg tctggcagaa cttcgtaagt ctggagaaat tagctatctc   615660
cgtccagatg caaaatcaca agttacagtt gagtacgatg aaaatgaccg tccggtacgt   615720
gtagatacag tcgttatttc tactcagcat gatccagagg ccactaatga acaaatccat   615780
caagatgtga ttgacaaggt catcaaagaa gttattccat cttcttatct tgatgataag   615840
acaaaattct ttatcaatcc gacaggtcgt tttgtaatcg gtggtcctca aggggactca   615900
ggtttgactg gtcgtaagat tattgtagat acttatggtg gctactctcg tcatggtggt   615960
ggtgccttct ctggtaaaga tgcgactaag gtggatcgtt cagcctctta tgcggctcgc   616020
tatattgcca agaatatcgt tgcagcagac cttgctaaga aggcagaagt gcagttggcc   616080
tatgctatcg gtgttgcgca acctgtttct gttcgtatcg atactttcgg tacaggaaca   616140
gtagctgaaa gtcaacttga aaaagcggct cgtcaaatct ttgaccttcg ccctgcaggg   616200
attatccaaa tgctggacct caagcgtcca atttaccgtc aaacatcggc ttacggtcac   616260
atgggacgta cagatattga tcttccatgg gaacgtttgg ataaggtaga tgctttgaaa   616320
gaagcagtaa aataagattt taagagggga acgtcctctc ttttttatag tttttaacta   616380
tactgggata ctgttctgaa aatccatttt gcgaaagtag agatttacat gtatagtaga   616440
ttgaaactag aatagtacac ctcaacttct aaaacattgt tagcaatcaa tttgactgtc   616500
ctgatcgatt tctcctgttc ttgtttcatt ttactatatt tctttaaaaa tgataaaggt   616560
taagatttct cctcgtaata gataatcttg gggatatttc aatccaaagt tttattcgtt   616620
atcacttgac tattgcaagg ttttctagag caacagagtc atggaatgga ctcatggttg   616680
agatttctcc ttgttgcttg gacttcattc aaaagtctgt tacccaagcc ttgttcaaac   616740
ttctaataca ctagctgttt ccatagcatg acttctgtac tagactttct tttccgaata   616800
aatagataga accacagaat ctagtaaacc tagaattaaa attatggtat aatattagca   616860
ataaaagaaa tctggaggat tagaatcatg gtatcaacga aaacacaaat tgctggtttt   616920
gagtttgaca attgcttgat gaatgcagca ggtgtggctt gtatgacgat agaggagtta   616980
gaagaggtca aaaactcagc ggcaggaacc tttgttacta agacagcgac cttggacttc   617040
cgtcagggga atcctgagcc acgctaccaa gatgttccac ttggttccat caactctatg   617100
ggcttgccaa ataatggctt agactattat ttggattatc ttttagattt gcaggaaaaa   617160
gagtcgaacc gaactttctt cttatctctg gtcggcatgt ctccagagga aacccatact   617220
attttgaaaa aagtccaaga gagtgatttt cgtggtctga ctgagctaaa tctttcctgt   617280
ccaaatgttc caggtaaacc tcagattgcc tatgattttg agacaacaga ccggattttg   617340
gcagaagtgt ttgcttactt caccaaacct cttggaatta aattgccacc ttattttgat   617400
attgttcact ttgaccaagc ggcagctatt ttcaacaaat atccgctcaa gtttgtcaac   617460
tgcgttaact ctatcggaaa cggcctctat atagaagacg aatctgtcgt tattcggcct   617520
aagaatggtt ttggtggaat tggtggagaa tacatcaaac cgactgcttt agccaatgtt   617580
cacgcctttt atcaacgttt aaatcctcaa atccaaatta tcggaacagg tggcgttctg   617640
actggtcgag atgcctttga acacatcctc tgtggagcaa gtatggtgca ggtgggaacg   617700
acccttcaca aagaaggcgt cagtgctttt gaccgcatta ccaatgaact gaaagcaatc   617760
atggtggaaa aaggctacga gagcttagaa gatttccgtg ggaaattgcg ctatattgac   617820
taaattaaat cgaaaaatct gaagaaagga gagacgatgc tagccattga agaaagtcag   617880
aagttgactt tatcaaattt accgagcctg agcctattta cagggacaga tcagggtcag   617940
tttgaagtga tgaagagtca aatgttgaaa cagattgggt atgattctgc tgacctcaac   618000
tttgcctact ttgatatgaa agaagtagtt tacaaggatg tggaactgga gttggtcagc   618060
cttcctttct ttgcggatga gaaaatcgtg atattagatt attttatgga tatcacgact   618120
gctaagaaac gctttttgac agatgatgag cttaagtcat ttgaggaata ccttgacaat   618180
ccttctccaa caaccaagtt gataatcttt gcagaaggaa agctggatag caaaagacgg   618240
ttagtcaaat tacttaagcg tgatgccaag gccttcgatg cagtagaagt aaaagaacaa   618300
gaattgcgcc agtacttcca aaagtggagt cagaaacaag gtctgcagtt taccaatcat   618360
tcttttgaaa atctcctcat caagtcgggg tttcaattta gcgaaatcca gaaaaatctt   618420
ctctttttac agtcctataa ggcgaattct gttattgagg aagaggatat tgttaacgca   618480
attcccaaga ccttgcagga caatattttt gatttaactc agtttattct gactaaaaag   618540
atggatcagg cgcgcgattt ggtgagagac ttgaccttgc aaggggaaga tgaaatcaaa   618600
ctgattgcag tcatgctggg acaatttcgg acttttactc aggtgaagat tttggcggag   618660
tctggccaaa cagaatcgca gattgcaagt agtttaggta gttatctggg acgtaaccca   618720
aatccttatc aaatcaagtt tgcattaaga gattcgagag gactttcttt gagctttttg   618780
aagcaagcta tttcctattt gattgagaca gactatcaga ttaagacagg tctttatgaa   618840
aaaggtttcc tttttgaaaa ggcactctta cagattgcta gtcaggtcaa ttgacatttg   618900
ttgaaactac aacccgcgtc aggactatct tgtcgtgggt ttcttgctga tttgcttatt   618960
ttattagaaa gtatgtcagt gatttcctta tctataagca aaaaacttga aaaaagtgaa   619020
tgtttgcgtt atcattttca tatagaaaga aaaagaggta ttacagatgg ctattatctt   619080
accagaactt ccatatgcat acgacgcttt ggaaccatac atcgatgcgg aaacaatgca   619140
tttgcaccat gacaaacacc atcaaactta tgtcaacaat gccaatgcag ctttagaaaa   619200
acaccctgaa atcggtgaag accttgaagc cttgcttgct gatgtagaat ctatcccagc   619260
tgatatccgt caagcactta tcaacaatgg tggcggacac ttgaaccacg ctcttttctg   619320
ggaattgatg actcccgaga aaacagctcc ttcagcagaa ctggcagcag caatcgatgc   619380
aacatttggt tcatttgaag aattccaagc agccttcact gcagcagcaa caactcgttt   619440
tggttcaggt tgggcatggt tggttgtcaa caaagaaggg aaacttgaag tgacttcaac   619500
agcaaaccaa gacacaccaa tctcagaagg taaaaaacca atcttgggct tggacgtttg   619560
ggaacatgct tactacgtga aataccgcaa cgtgcgtcct gactacatca aagctttctt   619620
ttcagtaatc aactggaata aagtagatga attgtacgca gctgctaaat aatgatagtt   619680
ggagggaaga attgttcttc tctttttagg ttataagatt ctggtctgac aaaatcgtca   619740
gacttttttc atttttatga gaaacgtgct aactgctaga aattatggta gaataaagta   619800
ttaagtaatc gtgaaaaaag gatatctatg cgaaaagaaa ttgcacctga attatacaac   619860
tataacaagt ttcctggtcc ggagttccat ttacacgggg acaaggtcga aacggaaggg   619920
atagcttttt ccttggttga aaatatcaag gatgcctttg atgtgacgac ttttaatcag   619980
cgtttttcag aagtattaac caagtttgat tatatcgtgg gggactggag caacgaacag   620040
cttcgcctac gaggttttta caaggatgac cgaacagaag aaaaacttga aaaaatcagt   620100
cgtttacaag actacctttt agagtattgt agttatggtt gtgcctattt tgtcttagaa   620160
aatgaagccc ctaagcgagc atcatttgac aagaaaatgc gtaagacgga agaagaaaca   620220
ccttctagaa aaggaaagaa accgactcaa actaaacgaa agtcgaatgc agataagaaa   620280
aatagacgtc gtcagaaaga cgacaaggga caacgtcatt ttgtcattcg tcagaagtga   620340
gtagagaata aggagaagaa atgaaaccct caattcatag tttggtacat caaaccatgc   620400
aggaatgggt attggagcag ggagaaaaga aattccgtgc agatcaaatc tgggaatggc   620460
tctaccgtaa acgtgtgcag tcatttgaag aaatgaccaa cctttccaag gatttgattg   620520
ctaagctcaa tgaccagttt gtggtcaatc ccttgaaaca acgtattgtg caagagtctg   620580
ctgatggtac agtcaaatat ctctttgaat tgcccgacgg tatgttaatt gagactgtac   620640
tcatgcgtca acactatggt ttatctgtct gtgtgaccac tcaggtcggc tgtaatatcg   620700
gttgtacctt ctgtgcctct ggtttgatta agaagcaacg tgacctcaat aacggtgaaa   620760
tcgtagcgca aatcatgctg gttcagaaat actttgatga gcgtggtcag gatgaacgca   620820
tcagccatat cgttgtcatg ggaatcggtg agccctttga taattacaac aatgtcttga   620880
atttctttcg tactatcaat gatgataaag gaatggctat cggtgctcgt cacatcacgg   620940
tttcaacctc aggtttggct cataaaattc gtgactttgc tgatgaaggg gttcaggtca   621000
atcttgccgt gtctcttcac gcacctaaca atgaacttcg ttcaagtatc atgaagatta   621060
accgtgcctt tccgattgaa aaactctttg ctgctattga atactacatt gagacaacaa   621120
accgtcgtgt aacctttgaa tatatcatgc ttaatgaagt caacgacggt gtagaacaag   621180
ccttggaatt gactgaattg ctcaagaaca tcaagaaatt gtcttatgta aacttgattc   621240
cttataaccc agttagtgag catgaccaat atagccgtag tcccaaagag tgcgtgttgg   621300
ctttctatga tacgcttaag aaaaaagggg tcaactgtgt ggttcgtcaa gagcatggta   621360
cagatattga cgcagcttgt ggacaattgc gctctaacac aatgaaacgt gaccgccaga   621420
aggcagtcgc agcggtaaat ccttaatgat gaagaagact tataatcata ttttggtctg   621480
gggagtcatt ttctatagca tttgcattgt ctgtttttgc tttactcctc aagaacaatc   621540
taccgtggga gtgggaactc caggtattca gcatcttgga cgcctggttt ttcttttgac   621600
tcctttcaat tctctctgga aactgggcga agtgagtgac attggacaat tatgttggat   621660
ttttttacaa aatatcctca atgtcttctt gttttttcct ctgattttcc aactccttta   621720
tctatttcca aatttgcgga aaacaaaaaa ggtccttctt tttagttttc ttgtgagtct   621780
tggaatcgag tgtacgcaat taatcttgga ctttttcttt gatttcaatc gcgtctttga   621840
gattgatgat ttgtggacca acactttggg tggctatctg gcttggctcc tttataaacg   621900
attacataaa aacaaggtaa ggaattaaaa tgagtatttt agaagttaaa aatctgagtc   621960
acggttttgg tgaccgtgca atttttgaag atgtgtcctt ccgtctcctc aagggagaac   622020
atatcggcct ggtcggtgcc aatggtgaag gaaaatcaac ctttatgagt atcgtgactg   622080
gtaaaatgct gccagatgaa ggaaaggttg agtggtccaa atatgtgacg gctggttact   622140
tggatcagca ctctgtcctt gctgaaagac agtcggtgcg tgatgttctc cgtacggctt   622200
ttgatgagct tttcaaagct gaagctcgta tcaatgacct ctatatgaaa atggctgaag   622260
acggcgcgga tgttgatgct ctcatggaag aagtaggaga acttcaagac cgtctggaga   622320
gtcgtgattt ctataccttg gatgctaaga ttgacgaagt agcgcgtgct cttggtgtta   622380
tggactttgg catggatacg gatgtaactt ctttgtcagg tgggcaaaga accaaggtgc   622440
ttttggcaaa acttctcctt gaaaagcctg atatcttgct gttggacgag ccgaccaact   622500
acttggatgc tgagcatatt gattggctca agcgctatct ccaaaactat gagaatgcct   622560
ttgttctcat ttcgcacgat attccattcc tcaatgacgt tattaatatt gtctatcatg   622620
tggaaaatca acagctgacg cgttactctg gtgactacta ccagttccaa gaagtttatg   622680
ctatgaagaa atctcagcta gaggcagcct acgaacgcca gcagaaagag attgcagacc   622740
tcaaggactt tgtggctcgt aataaagccc gtgttgcaac tcgtaatatg gctatgtctc   622800
gtcaaaagaa attggataag atggatatta tcgaactcca aagtgagaaa ccaaaaccat   622860
cctttgattt caaaccagct cgtacaccag ggcgctttat cttccaagcc aagaacttgc   622920
aaattggtta cgaccgtcct cttactaagc ctttaaatct taccttcgaa cgcaatcaaa   622980
aggttgcgat tattggtgct aatggtattg gaaaaacaac tctcttgaag agtctcttgg   623040
gcattatctc gccaatcgct ggggaagtgg agcgtggaga ttatttagaa cttggttatt   623100
ttgagcagga agtagaaggc ggtaatcgcc aaactcctct tgaagctgtc tggaatgcct   623160
ttcctgccct taatcaagca gaagtccgtg cagcccttgc ccgttgtggt ttgacaacca   623220
aacatattga aagccagatt caagtattat cagggggaga gcaagccaag gttcgtttct   623280
gtctcttgat gaatcgtgaa aacaacgttt tagtgctgga cgagccgacc aaccatttgg   623340
atgtggatgc aaaggatgag ctcaaacgcg ctctcaaaga atatagggga tctatcctta   623400
tggtctgcca cgagccagac ttttatgaag gctggataga ccaaatatgg gattttaata   623460
atttaactta agaatgagag taaaagaaat acagtaccga atgtggatac tgtatttttt   623520
tggtttttaa gatttaaaat cgtagtcttt caccacttcg atgctgtcga ttgtgatagc   623580
agtagttggc ttgtcttttt catctttttc ggccttagca atcttatcca caacatccat   623640
accgtcaatc acttgaccaa agactgggtg tttgccatct agactagggt ttccaccttc   623700
tttgtaggct tcaataattt tctgtggata cttgcttgta gggagtttag aagaggtatc   623760
tgtagagttt tggttgatga agaactggct gccattggtg tttggttgac cagtattagc   623820
catagcaaga gcaccacgga tgttatacaa ataaggagta atctcgttct tgaaaccagt   623880
tcctttgtct ttagtcttat ccttgtcatg ccagatggac tgaccacctg taccgtcccc   623940
ttttggatct ccagtttgga ccataaagcc atcgatgaca cggtggaagg taataccgtt   624000
atagtagcct tctttggcgt gagtgaggaa attttcaacc gctagaggag cgagtttagg   624060
gaagagttta atgcgaatat caccttggct tgtgtggaaa atcacttcgg cttcatcttc   624120
agcaacttcc ttagatagtt gtgggaaatt ggcgttttcg tttgttaaag catcgtttaa   624180
ctccttggca gattgggcag ctactttgga actttcttca gcagcaagac tggaatcaac   624240
ataatcatca ccacgcagac tgcgttggac gctgctacac ccagctaggg ctacagtaga   624300
cagtaaaaga agggttgcta gttttttcat tctgatcctc tcaaaaattc atttataacc   624360
attgcaccct aaaaggaagt ggatttcaaa tattagtagt ttacagaact ggcttagata   624420
atagttggga tttcatcatc atcttgaaaa tcttcaactt cttccccagt aaatggtttc   624480
tgaaaagaac ttagtataaa acgggcaatt ggttcaacaa ttaggaaatt tagaggaaga   624540
gctgcaataa agtttacgaa ccaggcgctt agataggtat tgggtgtgat agcaatgcca   624600
ttgtaaaaaa agtccataga aggacatgaa agtgaccagc taattcttct tctgaaaaat   624660
gctcatgaag ggcttgatcc aggtcgcaag atttcatttt agaaagtcca gtaactccct   624720
tcttcttcag gatattcttt ttcatggtat tatttagatg gtcaagtgag tcaaaagaag   624780
tttcgacaag agcataccct ttttctacca gagtttttag atgtttaggg gcatcaatac   624840
cataagtgta ctcaaagtat tttggaaacc agatcttaag aaagctcgta aagctagcca   624900
gttctctaaa cgctaagaac tagctacaac acagcattta caacacttca tggttcacac   624960
catggggtgt tttttaatga ttttaagcaa aattcacact taattgaaag ttatttaaat   625020
tagatgaaaa tttatttttt gaaaaagtgg gaaaacattg attctaagcg aattttgaat   625080
catattcgaa tgggagtttt taaaatcatg tttcagtggt aaaagtacca aactggattc   625140
tccatagtaa aatgatatct cctgctagtg aatcatctac taataagtcc atatttcgct   625200
tgggaacggg cttgggactt agaagccaag tatccaactc tcgttcaggc gatatgaagg   625260
gtttgacttg gtgttcttta taaaattttt ctaaaatagt attcacggat agcatctttc   625320
aaacatttat ttcctattct aacaaatttc taaatacttt aagaaattta tagtctgtca   625380
agtttttttc ttgacacatg ccagaaatct gctataatag aacatgtgct aaatagctca   625440
gctatttcac cgaaataaaa aattaaagaa atgagacttt aaaaatggca gttaaaatcc   625500
gtttgactcg tatgggttct aagaaaaaac ctttctaccg tatcaacgta gcagattcac   625560
gttcaccacg tgacggacgt ttcatcgaaa cagttggaac ttacaaccca cttgttgctg   625620
aaaaccaagt aactttgaaa gaagaccgcg ttcttgcatg gttggctaat ggagctcaac   625680
cttcagacac agtacgtaac atcctttcaa aagaaggcgt attgaaaaaa ttccacgatt   625740
ctaaattttc aaaataagtt taaagtaggt tgacagatgg atacgattga aaatctcatt   625800
attgcgattg tgaaaccctt aatttcacaa ccagatgcct taactatcaa gattgaggat   625860
acaccagaat ttttggaata tcatttgaat cttgatcaaa gcgatgtggg tcgtgtaatc   625920
ggtcgtaagg gtcgcactat ttctgcgata agaacgattg tctactctgt cccaactgaa   625980
tacaaaaaag taagaatcgt tattgacgaa aaataagaag ggcgggacgg atgtctcgct   626040
tttttgtgtg gaatagaaga tatagtaaaa tgaaacaaga acaggacaaa tcgatcagga   626100
cagtcaaatc gatttctaac aatgttttag aagtaaaggt gtactattct agtttcaata   626160
tactataaaa gattgaacgt ttaggcaatt ccaagactac ttaatcgaac attaacagca   626220
gtctcggact gatgaaggtc tctttatgaa gttagtggag gaagtcggag aagtagtcga   626280
ggttttgaat aggcgctctg gtcgaaaaga agggatagga ttcgaacgag gaacttgcca   626340
gagaactggc tgatatcatt tactacaccg tcgcaatcgt agctattaat catattgacc   626400
ttaccaagac tgtctttgag aaagacaaaa ccgcagccat taattaccaa cataaacata   626460
atttggaagg attattgaag ggaaagtaga gatattgtcc ccttcctcca acttgagaaa   626520
atccttggaa cgtgataaaa taaaggataa ggatttttaa taattcatta tatagaatca   626580
gtggatttct ttatgaagag gtttgaagta tctacagaaa ttggtagcct ctctgttact   626640
tatcaaaagc aaaagaaagt gctagtttgt ttaaacggag caggtttgct accaagttat   626700
gaaaattttt cacttatact tgaaaaacct cctcctacaa ttggttattt gacaattgat   626760
tttccgaaca caggtaggag tccgattcat gaccaagctg gaaaaaatct agataatctt   626820
gcagatgcgg tttatgaagt acttgaagaa ttaggaattt ctgaatatat actttgtgca   626880
catagttgga gtggaatttt agcttgcaaa ttactcgaga aaccaattaa gcgtcagact   626940
ttagtagcaa ttgaaccgac aactaaaaaa gtcatgtttg ctgatttttc agaaaatcct   627000
tatccagaaa tggaagagca gatgaggctg attgacgagt gtggtcctga actttatttt   627060
aagaacttaa ctcaagcaac atttagtcct gaaacgaata aaaaaatctg ggaattaatg   627120
caagaaaaag gcttagagtt ggaaaatcaa gatccagaat ttcagatatc tggagagatt   627180
actgaggaag attttgagga tgtatctata gaagctcata ttcctgtatt tgttttttgt   627240
cagccttata gagaaaaaga gtacagagaa tcagaatatt ggacttccaa tactaaactc   627300
attttaggag ggaatcacca ttatttacaa tggtcagaat cggaaaaaat tgcggctatt   627360
attcgagaat tgttagaata agatggaaaa aaggagatta caggagacaa gatgaactac   627420
tttaatgttg ggaaaatcgt taatacgcag ggattacagg gggagatgcg agtcttgtct   627480
gtgacggatt ttgcagaaga acggtttaaa aaaggagctg agctggtttt gtttgatgaa   627540
aaagatcagt ttgtccaaac agtgaccatc gctagccacc gtaaacagaa gaactttgac   627600
attattaaat tcaaagatat gtaccatatc aatactatcg aaaagtacaa gggatacagt   627660
ctcaaggtcg ctgaggaaga tttgaatgac ctagacgatg gtgaatttta ctatcacgag   627720
attatcggtt tggaagtcta tgagggtgat agcttggttg gaaccatcaa ggaaatcctg   627780
caaccaggtg ctaatgatgt ctgggtggtc aaacgaaaag gcaaacgtga tttgctttta   627840
ccttatatcc caccagtggt tctcaatgtt gatattccaa gtaaacgggt cgatgtggaa   627900
atcttagaag ggttagacga tgaagattga tattttaacc ctctttccag agatgttttc   627960
tccactggag cactcaatcg ttggaaaggc tcgagaaaaa gggctcttgg atatccagta   628020
tcataatttt cgagaaaatg ctgaaaaggc ccgtcatgta gatgatgagc cctacggagg   628080
cggtcagggc atgttgctca gagcacaacc tattttcgat tcctttgatg ctattgaaaa   628140
gaaaaatccg cgcgttattc tccttgatcc tgctggaaag cagtttgatc aggcttatgc   628200
tgaagatttg gctcaagagg aagagctaat ctttatctgt gggcactatg agggttatga   628260
tgagcgcatt aagaccttgg taacagatga gatttcccta ggtgactatg tcctcactgg   628320
tggagaattg gcagctatga ccatgattga tgctacagtt cgcctgattc cagaagtgat   628380
tggcaaggag tctagccacc aagatgatag tttttcttca ggtcttttag aatatcctca   628440
gtacacacgt ccctatgatt atcgaggcat ggtcgtgcca gatgtattga tgagtggcca   628500
ccatgaaaag attcgtcagt ggcgattgta cgagagttta aagaaaacct acgagcgcag   628560
accggattta cttgaacatt atcaactgac agtagaagaa gaaaaaatgc tggcagaaat   628620
caaagaaaac aaagaataaa ggagaaacct atgcaagtaa tcaaacgtaa tggcgaaatt   628680
gctgaattta atccagataa gatttaccaa gccatcttga aggcagccca aactgtttat   628740
gttttgacag atgatttgcg tcaaaatctt gctcaagtca ctaagaaggt agttttggat   628800
ttacaagaag ccaaggtgga acgtgcgact atcagtatga ttcaatctat ggttgaacat   628860
cgtttattgg gcgcaggtta cattaccatt gcagaacact acatttccta tcgtttacaa   628920
cgtgacttgg aaagaagtgg ttatggagat catatcgcag ttcatttaca ttttgaacaa   628980
attcgctaag aaaaaagagt gggatgaagc aactacatct cactctttct taaatctatt   629040
tttttgggct gtttggacag ttgaggggac aaatcgcagg cgttgaatat cgcttatacg   629100
gataatccgg ctcacatttt tggaaaaatt tttcacgata atttgctggc cttgctgatc   629160
atatttgatg atgtcacctg taaagcttgt ctcagacaag ataaggtgaa cagcggtttg   629220
tttctggata gcctcttcaa tagtggctgt aagggagttg gtttcagtct ggtcaggttg   629280
gtcatatcca tttaaaaaat catgtatttt atttagaact tgctggaatt tatgtctcat   629340
attggcctcc cttcttttat atcaatatta tataaaattt tcctaaaatc tacaagattt   629400
tacgaataaa ctaatgaaac taaaaaagga gaagaaaatg gcagaattta catttgaaat   629460
cgaagagcac ttgttgactc tttctgaaaa cgaaaaaggt tggaccaagg aaattaaccg   629520
tgtgagcttt aatggtgccc ctgcaaagtt tgatattcgt gcttggagtc cagaccatac   629580
taaaatgggc aaagggatta ctctctcaaa tgaagaattt caaacgatgg tggatgcctt   629640
taaaggcaac taatactctt cgaaaatctc ttcaaaccgc gtcagctttg ccttgccgta   629700
tgtatggtta ctgacttcgt cagtttcatc cacaacctca aaacagtgtt ttgagcagcc   629760
tgcggctagc ttcctagttt gctctttgat tttcattgag tataagtttt caaaataaaa   629820
gaaaaggata ttgagtcatg ataactcgat atcctttttt agttagtaaa gtaagcctga   629880
tttttaaggc gttgaagtag gggacggcta ataaaactaa tagctagaag tttgccaagg   629940
tctggaatga taaagggaag aacccccaca gcaagagctt tttcaaatgc cattccagct   630000
aggaaatgca agctgagaat cccgccgaca aagacaaggg catcacccaa gaggtttgca   630060
agaaaaatct taacaacacc actcttgctg ttggttagag aggaagtaag tccagagtaa   630120
acgagataaa accaaagata gcctgcagta gggccaacta aagcctgaaa accagctcca   630180
cctcctgcaa agacaggaag accgatagca cctagaagaa gatagagtcc agcagaaagt   630240
acagcctctc tcggtctaaa gacagtagca atcaagccga ttgcaaagtt ttgcagagtg   630300
aagggaacag gtccaattgg aagactgatt tgtgccaaag cagcaatgag agcagcccca   630360
atagcaggga tagcataaac gtgagctttt ttcaaaatag ttaacctctt ttctaatgta   630420
tagtaactat tatactcata taggagtcga tgtcaaccat tttttaaaaa caaggtaaca   630480
aaaactgtaa cagccgattt tcgtgactag tcaagttgga taattttttt gttgattcga   630540
aaatcattaa aaaagaagca gacatattta tatcagcttc ttttgtttcg attaacgcat   630600
ggttacaaat tcttcagatg cagttgggtg aattgccaca gttgcatcaa agtcagcctt   630660
ggttgctccc attttgatag caacggcaaa tccctgaatc atttcatcaa cgccgtagcc   630720
aattccatga agtccgacaa ctttttcttc tgaaccagct gttatgagtt tgaaacggga   630780
ttcttgacgg ttgcaagtgc aagcagagta catagatgca aagcttgatt tataaacctt   630840
gatttggtct tgaccgtatt ctttaatagc ttgctcttct gtcaaaccaa cagttccgat   630900
agcagggtgt gaaaagacaa cagttggaat agttgagtaa tccatttttg cagtagtttt   630960
tccgttaaag agacgttcag atagggtacg tccggccttg attgcaactg gagtcagttc   631020
tttctcgccc gttacatcac ctagagcata gattccctca acaacagtat tttggtattc   631080
atccacttgg ataaagccac gttcgttcag agtcactcca gctttttcaa gttgcaagcc   631140
cttaacgttt ggacggcgac ctgtagccca gataacttgg ctagctgtgt gactagtacc   631200
atcttcgaaa tgaatggtaa tgccgtcagt agttttttct aacttgacag ggactttgtg   631260
agtgtgaagt ggtaagtttg ttctttccat ttccttgacc aaaccttcaa cgatgtagga   631320
atcaaaacca cgtaaaggac gatcgcggcg aacaaagaga tctgtcttga caccaaaagt   631380
gtggagtacg ccagctaatt caacggcgat ataaccagcg cctagaatgg caattgactc   631440
tggaagttct tcccaggcaa atacatcatc agaagagcca cctagctcag caccaggaat   631500
attaggaata cttggatggg cacctgtagc aatcacgata tgtttagcac gaatcagttc   631560
accatttacg cttacagtat gagaatctac aaattcagca tgaccttcaa tcaagtctac   631620
accgttgcgt ttaaaactac catcataaga agaacgagcg cgatcaatgt aggcttcacg   631680
attgcgacgt agggttgcaa agtcaaagtt aagatcagta gtcttaaagc cgtagtcttc   631740
tccaaattga tggaaagtct cagcgatttg cgccccgtac cacatgattt ttttaggaac   631800
acaaccgacg ttgacacagg ttccacctaa tttcttttcc tcaataacgg ctgctttggc   631860
tccatgttca ccagcacggt tcatggtagc gattcctccg ctacctccac cgatagcaat   631920
gatatcatat tctctcattg aaaactcctt tgtaatcttt taaatagtag agcgtctttt   631980
ttgatagtta tattttattc tttttttgat ttgattgcaa aaatctgcta cgcacaaaaa   632040
attgcaaaaa agcttgccaa ataagtcaag atagtgtatt atatatctag tacaatagaa   632100
aagcaaaatt ccgaacgatt gtttaatcct gaactgtatt gtttgctgga gggaaatttg   632160
gtataatagc aaagtattgt aaaaaagaaa aggagtttca ttatgaagaa aaagaatggt   632220
aaagctaaaa agtggcaact gtatgcagca atcggtgctg cgagtgtagt tgtattgggt   632280
gctgggggga ttttactctt tagacaacct tctcagactg ctctaaaaga tgagcctact   632340
catcttgttg ttgccaagga aggaagcgtg gcctcctctg ttttattgtc agggacagta   632400
acagcaaaaa atgaacaata tgtttatttt gatgctagta agggtgattt agatgaaatc   632460
cttgtttctg tgggcgataa ggtcagcgaa gggcaggctt tagtcaagta cagtagttca   632520
gaagcgcagg cggcctatga ttcagctagt cgagcagtag ctagggcaga tcgtcatatc   632580
aatgaactca atcaagcacg aaatgaagcc gcttcagctc cggctccaca gttaccagcg   632640
ccagtaggag gagaagatgc aacggtgcaa agcccaactc cagtggctgg aaattctgtt   632700
gcttctattg acgctcaatt gggtgatgcc cgtgatgcgc gtgcagatgc tgcggcgcaa   632760
ttaagcaagg ctcaaagtca attggatgca acaactgttc tcagtaccct agagggaact   632820
gtggtcgaag tcaatagcaa tgtttctaaa tctccaacag gggcgagtca agttatggtt   632880
catattgtca gcaatgaaaa tttacaagtc aagggagaat tgtctgagta caatctagcc   632940
aacctttctg taggtcaaga agtaagcttt acttctaaag tgtatcctga taaaaaatgg   633000
actgggaaat taagctatat ttctgactat cctaaaaaca atggtgaagc agctagtcca   633060
gcagccggga ataatacagg ttctaaatac ccttatacta ttgatgtgac aggcgaggtt   633120
ggtgatttga aacaaggttt ttctgtcaac attgaggtta aaagcaaaac taaggctatt   633180
cttgttcctg ttagcagtct agtaatggat gatagtaaaa attatgtctg gattgtggat   633240
gaacaacaaa aggctaaaaa agttgaggtt tcattgggaa atgctgacgc agaaaatcaa   633300
gaaatcactt ctggtttaac gaacggtgct aaggtcatca gtaatccaac atcttccttg   633360
gaagaaggaa aagaggtgaa ggctgatgaa gcaactaatt agtctaaaaa atatcttcag   633420
aagttaccgt aatggtgacc aagaactgca ggttctcaaa aatatcaatc tagaagtgaa   633480
tgagggtgaa tttgtagcca tcatgggacc atctgggtct ggtaagtcca ctctgatgaa   633540
tacgattggc atgttggata caccaaccag tggagaatat tatcttgaag gtcaagaagt   633600
ggctgggctt ggtgaaaaac aactagctaa ggtccgtaac caacaaatcg gttttgtctt   633660
tcagcagttc tttcttctat cgaagctcaa tgctctgcaa aatgtagaat tgcccttgat   633720
ttacgcagga gtttcgtctt caaaacgtcg caagttggct gaggaatatt tagacaaggt   633780
tgaattgaca gaacgtagtc accatttacc ttcagaatta tctggtggtc aaaagcaacg   633840
tgtagccatt gcgcgtgcct tggtaaacaa tccttctatt atcctagcgg atgaaccgac   633900
aggagccttg gataccaaaa caggtaacca aattatgcaa ttattggttg atttgaataa   633960
agaaggaaaa accattatca tggtaacgca tgagcctgag attgctgcct atgccaaacg   634020
tcagattgtc attcgggatg gggtcatttc gtctgacagt gctcagttag gaaaggagga   634080
aaactaagat gcagaatctg aaatttgcct tttcatctat catggctcac aagatgcgtt   634140
ctttgcttac tatgattggg attattatcg gtgtttcatc agttgttgtg attatggctt   634200
tgggtgattc cctatctcgt caagtcaata aagatatgac taaatctcag aaaaatatta   634260
gcgtcttttt ctctcctaaa aaaagtaaag acgggtcttt tactcagaaa caatcagctt   634320
ttacggtttc tggaaaggaa gaggaagttc ctgttgaacc gccaaaaccg caagaatcct   634380
gggtccaaga ggcagctaaa ctgaagggag tggatagtta ctatgtaacc aattcaacga   634440
atgccatctt gacctatcaa gataaaaagg ttgagaatgc taatttgaca ggtggaaaca   634500
gaacttacat ggacgctgtt aagaatgaaa ttattgcagg tcgtagtctg agagagcaag   634560
atttcaaaga gtttgcaagt gtcattttgc tagatgagga attgtccatt agtttatttg   634620
aatctcctca agaggctatt aacaaggttg tagaagtcaa tggatttagt taccgggtca   634680
ttggggttta tactagtccg gaggctaaaa gatcaaaaat atatgggttt ggtggcttgc   634740
ctattactac caatatctcc cttgctgcga attttaatgt agatgaaata gctaatattg   634800
tctttcgagt gaatgatacc agtttaaccc caactctggg tccagaactg gcacgaaaaa   634860
tgacagagct tgcaggctta caacagggag aataccaggt ggcagatgag tccgttgtat   634920
ttgcagaaat tcaacaatcg tttagtttta tgacgacgat tattagttcc atcgcaggga   634980
tttctctctt tgttggagga actggtgtca tgaacatcat gctggtttcg gtgacagagc   635040
gcactcgtga gattggtctt cgtaaggctt tgggtgcaac acgtgccaat attttaattc   635100
agtttttgat tgaatccatg attttgacct tgttaggtgg cttaattggc ttgacaattg   635160
caagtggttt aactgcctta gcaggtttgt tactgcaagg tttaatagaa ggtatagaag   635220
ttggagtatc aatcccagtc gccctattta gtcttgcagt ttcggctagt gttggtatga   635280
tttttggagt cttgccagcc aacaaggcat cgaaacttga tccaattgaa gcccttcgtt   635340
atgaatgaga tcaacaagat ggacactcgt ctatcttgtt tttgtatgga tttccctatt   635400
gaaattcatt aaaaatgtga tataatgaag tgttagaaaa acaggtttca tttgcctgga   635460
aaggaaaaat tatgtctgaa aaaaattttt atattacaac gccgatttac tatccatctg   635520
ggaaacttca tatcggttct gcctacacaa ctatcgcatg tgatgtccta gcacgttaca   635580
aacgcctgat gggctacgat gtattttatc tgacaggtct tgatgaacat ggtcagaaaa   635640
tccagcagaa agcggaagaa gctggtatta cacctcaagc ctatgttgat ggaatggcgg   635700
ttggagttaa agaactctgg caattactag atatctcata cgataaattt atccgtacaa   635760
ctgatgacta ccatgaaaaa gttgtcgcac aagtctttga acgcttactt gctcaagatg   635820
atatctactt gggtgaatac tctggttggt attcagtatc agacgaagaa ttctttacag   635880
aaagccagct ggcagaagtt ttccgtgatg aagctggaaa tgtgactggt ggtattgctc   635940
catcaggtca tgaggttgaa tgggtttctg aagaatcata cttccttcgc cttagcaaat   636000
accaagaccg tttggtcgaa tttttcaaag ctcatcctga atttatcacg ccagatggtc   636060
gccttaatga aatgctacgc aacttcatcg agccaggctt ggaagatttg gcggtatctc   636120
gtacaacctt tacatgggga gtgcctgtcc catcaaatcc aaaacacgtt gtctacgttt   636180
ggattgatgc ccttcttaac tatgcgacag ctcttggcta cgctcaagac gaacatggta   636240
actttgacaa gttctggaat ggaacagtct tccatatggt aggaaaagat atccttcgct   636300
tccactctat ctactggcca atccttctta tgatgttgga tgttaaatta cctgatcgtt   636360
tgattgccca tggttggttt gtcatgaaag acggaaaaat gtctaagtca aaagggaatg   636420
tcgtttaccc tgaaatgttg gtagagcgtt atggactaga tccacttcgt tactacctca   636480
tgcgtaacct tccagttggt tcagacggaa cctttactcc tgaagactat gtcggccgta   636540
tcaactatga attggctaat gaccttggga acctccttaa ccgtacggtt tccatgatta   636600
ataagtactt tgatggacaa atccctgcct atgtagaagg tgtgactgaa tttgatcatg   636660
ttcttgctga ggttgcagaa caatcaatcg cagacttcca tacacacatg gaagcagttg   636720
actatccacg tgcgcttgaa gcagtctgga ctctgatctc tcgtaccaat aaatacatcg   636780
atgagaccgc accatgggtc ttggccaagg atgaagctct tcgtgaccaa ttggcaagtg   636840
tcatgagcca cttggcagcc agcattcgtg tagttgctca cttgattgaa ccatttatga   636900
tggaaactag tcgtgcagtt ttgactcaac ttggtttgga agaagtttct agtcttgaaa   636960
acttgagttt ggctgacttc ccagcagatg tgactgtagt tgccaaagga acacctatct   637020
ttccacgtct aaatatggaa gaagaaatcg cctatatcaa ggaacaaatg gaaggcaata   637080
aaccagcagt cgaaaaagaa tggaatccgg acgaagttga gctcaaacta aacaaggatg   637140
aaatcaagtt tgaagacttt gacaaggttg aaatccgtgt cgcagaagtc aaagaagtgt   637200
ctaaagtaga aggttcagat aagttgcttc aattccgctt ggatgctggt gatggagaag   637260
atcgtcagat tctttcagga attgcaaaat actatccaaa tgaacaagaa ttggtcggca   637320
agaaagttca aatcgttgct aacctcaaac cacgtaaaat gatgaaaaaa tatgtcagcc   637380
agggtatgat tctctcagct gaacatgatg gcaaattaac ccttctcaca gttgatccag   637440
ctgtaccaaa tggaagtgtg attgggtaaa agtagacagg actagttcag gctagttctg   637500
tttttttatt tatactcaat gaaaatcaaa gagcaaacta ggaagctagc cgcaggttgc   637560
tcaaaacact gttttgaggt tgtagacgaa actgacgaag tcagctcaaa acatgttttt   637620
gaggttgtag atgaaactga cgaagtcagc tcaaaacact gttttgaggt tgtagatgaa   637680
actgacgaag tcagctcaaa acactgtttt gaggttgtag atgaaactga cgaagtcagc   637740
tcaaaacatg tttttgaggt tgtagatgaa actgacgaag tcagtaacca tacatacggt   637800
agggcgacgc tgacgtggtt tgaagagatt ttcgaagagt attaactatt atgctttaca   637860
aactagtgta gaagtgatat actataggtg aagtcactag taggtattac aaaatagatt   637920
agaagggaga agtgatgaaa gaaactcagc tattaaaagg tgttcttgaa ggttgtgtct   637980
tggatatgat tggtcaaaaa gagcggtatg gttatgagtt ggttcagact ttgcgagagg   638040
ctggatttga tactatcgtt ccaggaacta tttatccttt gttgcaaaag ttagaaaaaa   638100
atcaatggat aagaggcgac atgcgcccgt cgccagatgg tccagatcgg aagtattttt   638160
cattaatgaa agaaggagaa gagcgtgtct cagtcttttg gcaacaatgg gacgatttga   638220
gtcaaaaagt agaagggatt aagaatgggg gttaaaccat gaagaaaatg aagtattacg   638280
aagaaacaag cgctttgcta catgagtttt ctgaggagaa tcaaaagtat tttgaggagt   638340
tgtgggaaag ttttaatctt gctggatttc tctatgatga agactatctc agagagcaga   638400
tctatttgat gatgctagat ttctcagaag cagaacgaga tggcatgagt gcagaggatt   638460
atctaggtaa gaatcctaaa aaaataatga aagagattct caagggagca cctcgcagtt   638520
ctatcaaaga gtcccttttg acgccaattc ttgtcctggc ggtattacgt tattatcaac   638580
tactaagtga tttttctaaa ggtcctctct taacagtcaa tttgctcaca tttttagggc   638640
aacttcttat ttttctgatt ggatttggac ttgtggccac aattttacga agaagtttag   638700
tccaagattc tcctaaaatg aaaattggca cttacattgt tgttgggact atagttcttc   638760
tagttgtttt aggatatgta ggaatggcaa gcttcataca agaaggagcc ttttatattc   638820
cggctccctg ggatagtttg tctgtcttta cgatttcgct agttatcggt atttggaatt   638880
ggaaagaagc ggtctttcgt ccatttgtca gtatgattat tgcccatctt gtggtgggtt   638940
ctctgctccg ttattatgag tggatgggaa tttcaaatgt tttccttaca aaagttattc   639000
ctttagctgt cctctttatt ggaatctttg tcttgttccg tgggtttaag aagataaaat   639060
ggagtgaagt atagtcaaaa agtcgttgca aagcggtttt ttgttataat gaagggaaga   639120
atgttagaaa ttaaaggaga aaaatttgat gagatacata actcttggtc aagatgacaa   639180
agaattatca gaaattgttc tcggaatgat gagaataaaa gataaatctg taaaagaagt   639240
tgaagagctt gtagaaacag cactttctgt tggaatcaat gccttcgact tggctgatat   639300
ttatggtcgt ggtcgttgtg aagaactgtt aggtcttgtc ctaaaaaatc gtccagattt   639360
aagagaaaag atgtggattc agtccaaatg tggcattcgc attgaagaat ttacctattt   639420
tgatttttct aaggactata ttataaaatc agtagacggt attttgcaaa gattgaagat   639480
tgatcatcta gatagcttgc tccttcatcg accagatgct ttgatggaat ctgaccaagt   639540
agcagaagcc tttaatctcc tttataaaca aggtaaagtt cgagattttg gagtttctaa   639600
tcaaaatcct atgatgatgg agttgcttaa aaaagatgtc aagcagccgt tagctgttaa   639660
tcagctacaa ttgagtgcgg cttttactcc aggatttgaa tcagcttttc atgttaatat   639720
ggaagatagt caagcagcta tgcgagatgg cagcattttt gaatattgcc aattacacga   639780
tgtggtcatt caagcatggt ctgtcttaca attcgggtat tttaaaggga attttgttgg   639840
aaatgagaaa tttcaagctt taaatcaagt acttgatcgt ttagctatta aatatggagt   639900
aacctcttca actattgcca tttcttggat attgcgttat ccagcaaaaa tgcaggcagt   639960
cgtaggtaca acaaatccta agcacttgag agaagttagc cgagcggcaa actttagctt   640020
aacaagaaaa gaatggtatg aaatttatct tgctgcaggg aataatttgc cgtaagtagt   640080
agcaggtttg aataactcac attcaaaaag ccgtataaag cggttttttg ctataattaa   640140
atgaagaatg tagaattaaa ggagaaaaac atgacatttg aagagatcct gcctgggtta   640200
aaggctaaga gaaaatatgt acgaactggt tggggaggtg cggaaaacta tgtccaactc   640260
tttgatacca tcgagcaaaa tgggcttgca cttgaaatga caccttattt cctaatcaac   640320
gtttctggcg aaggagaagg tttttccatg tggagcccga cagtttgtga tgttttggca   640380
acggattggg tagaagtgca tgactaaacg tgtactcatt acaggagtga gttcagggat   640440
cggattggct caagctcgcc tctttttaga gaagggctat caagtttatg gagttgacca   640500
aggtgaaaag ccactcttag agggtgattt tcgcttttta cagagagatt tgaccttgga   640560
cttggaacct atttttgact ggtgccctca ggtggatgtt ttgtgtaata ctgctggagt   640620
tttggatgat tacaaaccac tgttggaaca aacggcgcag gacattcaag agatttttga   640680
aatcaactac attattccag tagagttgac tcggtattat ttgacacaaa tgctggaaaa   640740
taaaaaggga atcatcatca atatgtgttc cattgcttct agcctagcag gtggaggtgg   640800
tcacgcctat acttcatcca agcatgcctt ggctggcttc accaagcagt tggctctaga   640860
ctatgctgaa gctgggattc aggtctttgg tatcgctcca ggagcagtca agacagctat   640920
gaccgctgcg gattttgaac caggtggttt ggctgactgg gtggctagtg aaaccccaat   640980
caagcgctgg attgagccag aggaaatagc agagcttagt ctttttttag caagtggaaa   641040
agcgagcgcc atgcaaggac aaatcttgac aatagatggt ggctggtctt tgaagtagga   641100
ggagttggat ggaaatcaaa aatcactttg gggtctactg tgtttgcttt gaaaatggaa   641160
agttactttg cattgaaaaa acgagaggcc cttatcaaca tcggtatgat ctacctggag   641220
gcagtcagca acttggtgaa ggactgacgg aaacgctgac tagagaagtt atggaagaga   641280
cgggatttac tgttagaagc tactctaatc ctcgaatcta cgatgttttc gtcagggaag   641340
agttaaaaaa ttttatggtt caccatgtca tagccttgta tgatgttgaa atgaatgaga   641400
gtgcacctca agttacgatt tcggaagctg tgtctgatgg tgcgaatgat tcacttggat   641460
atatttggat ggatattcaa gagattacag aagaaaatgc atcgccatta gtcttgaagg   641520
ttaagtctga attattagga tttccagaac tggacaagac ttcttacatg aattggaagg   641580
tgaatgatga gaaatcaact tgcccttagt ggcgaaaaaa ttcttgaaaa aatttatcct   641640
caactatttc accacgtcgg catgattcgt ggggaatact tattgagaga gctcaatcaa   641700
aatatactat tacaaagttg tcaggaattt gtgaaagatt atcttgatac tatttgctcc   641760
ttttacttag gtaaggaagt ttggtatcgt tttactgaat taacgaatac agaagccaat   641820
tgtttagtgg ggactaaaga gttttttgac gaagggcatc ccttgtttgg ctatagagga   641880
actaggcgtt tactggcgtg tttggatgaa tttcaggctg aagcacatgt cgttacagaa   641940
gtttatcaaa ccaaccccaa tctatctgtt atctttcctt ttgtcaatga tgccgaccaa   642000
ttaaaacaag ctattacagt attgcgtcag cagggtttta ctgggaaagt cggaacgatg   642060
attgaattac cgtcagcgta ttttgactta tctagtatac tggaaacggg catttcaaag   642120
attgtagttg gaatgaatga tttgacttcc tttgtttttg cgactatgag aaacagtcaa   642180
tggcatgata tggaaagtcc aataatgtta gatatgctaa gagatatgca ggataaagca   642240
agaaagaaca agattgattt tgctgtagca ggctatctga atacttcttt catacaaaaa   642300
atgaatcagt tgggtatcaa gtgcattatc cactacagtt ctattccaga gatttttgat   642360
ttagagattg accatccaga tcatcttaaa cacataaaag aagaaagtaa aaaattacaa   642420
aggagcaccc atgataccgc aagaaatgtg gaataaatac aagcaaatca atcctttgat   642480
cggagatgaa atcgatgcct gggcttttgg agttgaacca gaccttttag cggatttggt   642540
gtttaaagga gaaaagacag caacagcatc agcctatgac ctctatgtgc tagaagacga   642600
accacttccc caagtaggga ccttcgatgt cattttagat agtcaaaatc aggctgtctg   642660
cattgtcgaa attacaaagg tttctgttaa acccttcaat cgagtgtcag ctgaccatgc   642720
ctataaggaa ggtgagggaa acaagacact tgtctattgg cgccaggttc atgaggattt   642780
tttcagagac tgcttgggtg aagcaggatt gacttttaca cctgaaagca aggttgtttt   642840
agaagaattt cgcaaggtct acccactgta gactattaga aggaagaaag ttttggaaat   642900
cgctgtccaa tccttttttc tgaagcaaaa tatgatataa taagtttgtt tgaagaagag   642960
cagcagctct taaacttaga ataggagaaa actatgcaag cagttgaaca ttttattaag   643020
caatttgttc ctgaacatta tgatttattt ttagatttga gtcgtgagac caagactttt   643080
tctgggaaag tgaccatcac tggtcaagca cagagtgacc gcatctccct ccaccaaaaa   643140
gatttggaaa tcacctctgt agaagttgca ggtcaagctc gtccatttac agttgaccat   643200
gacaatgaag cccttcatat cgaattggct gaggctggtc aagttgaatt ggttcttgcc   643260
ttttctggta aaattacaga caacatgaca gggatttacc cttcttatta tacagttgat   643320
ggagtcaaga aggaggtctt gtctactcag ttcgagagcc attttgcgcg cgaagctttc   643380
ccatgtgtgg atgagcctga agccaaagca acttttgacc tctctcttcg ctttgaccaa   643440
gcagaaggtg aattggcctt gtcaaacatg ccagaaatcg atgttgaaaa ccgtaaggaa   643500
acaggtatct ggaagtttga gacaacacct cgcatgtctt cttacttgtt ggcctttgtt   643560
gctggtgatt tgcaaggggt gaccgctaaa actaaaaatg gtaccctggt aggtgtctac   643620
tcaaccaaag cacatccact ttcaaatctt gatttctcac tggatatcgc tgttcgctct   643680
atcgagtttt acgaagatta ctatggagtt aagtacccaa ttcctcaatc tctccacatc   643740
gcccttcctg acttctcagc tggtgctatg gaaaactggg gtcttgtgac ctaccgtgaa   643800
gtttacttgg ttgtcgatga gaactctaca tttgctagcc gtcaacaagt tgcccttgtt   643860
gtggcccatg aattggctca ccaatggttt gggaacctcg tgactatgaa atggtgggat   643920
gacctttggc tcaatgaaag tttcgctaat atgatggaat acgtctgtgt ggataccatc   643980
gaaccaagct ggaatatctt tgaagatttc caaacaggtg gagtacctct tgctcttgaa   644040
cgtgacgcta ctgatggcgt tcagtctgtc cacgtcgaag ttaaacatcc agatgaaatc   644100
aatacactct ttgacggcgc tatcgtctat gccaaaggaa gccgtctcat gcacatgctt   644160
cgccgttggc taggagatgc tgattttgct aaaggtttgc acgcctactt tgaaaaacac   644220
caatacagca acaccattgg tagtgacctt tgggatgccc ttggtcaagc gtcaggacgt   644280
gatgtcgcag ccttcatgga ttcttggttg gaacagcctg gttacccagt tcttactgtt   644340
aaagttgaaa atgatgtctt gaagatttca caaaaacaat tcttcatcgg tgagaacgaa   644400
gacaagaacc gtctctgggt ggtgcccctc aatagcaact ggaaaggctt gcctgataca   644460
ctcgaaactg aaagtatcga aatccctggc tacgcagctc ttcttgctga aaatgaagga   644520
gctcttcgtc tcaacactga aaatactgcc cactatatta ccgactatca aggagacttg   644580
ttagcagctg ttcttgctga gctagagaca cttgataaca caagcaaact gcaaattgtt   644640
caagaacgtc gtttgttggc tgaggcaggg cacatttctt atgcagactt gcttccagtt   644700
cttgataaac ttgctaagga agagtcttat ctggtggttt cagctgtttc tcaagtgatt   644760
tcagcccttg agcgctttat tgatgaagga acggatgctg aaacagcctt caaaggactg   644820
gttgctaaat tggctcgtca taactatgac cgtcttggtt ttgaagctaa agacggagaa   644880
tcagatgagg atgaattggt tcgtcagctg gctgtttcga tgatgattcg ctcaaatgat   644940
gcagaagcta gtcaagtcgc tagccaaatc ttcgcaacac acaaggagaa tcttgcagga   645000
ctcccagcag ctattcgctc acaagttctg attaatgaga tgaaacatca tgagactaaa   645060
gacttgttag cactttatct tgatacttat actcacgcaa cagatgctgt ctttaaacgc   645120
cagttggcag cagctcttgc atacagtaca gatgcggata atatccaaaa cctgattact   645180
tcttggaagg acaaatttgt ggtcaaacca caggacttgt ctgcttggta ttaccaattc   645240
ctagctcatc aagcaactca gaaaacagct tggtcttggg cgcgtgaaaa ctgggcttgg   645300
attaaggcag cccttggagg agatatgagc tttgatagct ttgttatcct tcctgctcat   645360
gtatttaaga ctcagcaacg cttggcggaa tacaaggagt tctttgaacc gcaactttct   645420
gaccttgctc ttagccgtaa catcggtatg ggaatcaagg aaattgcagc gcgtgttgac   645480
ttgattagcc gtgaaaaagc tgcagtcgaa gcagttgttc ttcaatacgg aaatgcataa   645540
ataagcctaa aataaaaaga aaactcagct atctcatgta aaatgcagag agttgagttt   645600
tttttaaggc aaatttggta taatagtttt aataaggagg agtttctcat gataaaaatc   645660
ttattggttg aggatgacct aggtctgtca aattcagtat ttgacttttt agacgatttt   645720
gcggatgtta tgcaggtatt tgatggagaa gaaggtctct acgaagctga gagtggtgtc   645780
tatgacttga ttttgctgga tttgatgttg ccagaaaaaa atggtttcca agtcttaaaa   645840
gaattgcgtg aaaagggaat tacgacacca gttctgatta tgactgccaa ggaaagtttg   645900
gatgacaagg gacatggatt tgaactggga gcggatgatt atctgaccaa acctttctac   645960
ctagaagaac ttaaaatgcg gattcaggcc cttctcaaac gttcagggaa gtttaatgaa   646020
aacaccttga cttatgggaa tatcgtggtt aatttatcaa ccaataccgt taaagttgaa   646080
gatactcctg tcgaattgct ggggaaagag ttcgatttac tagtttattt ccttcaaaat   646140
caaaatgtga ttttgcctaa gacgcagatt tttgaccgtc tatggggatt tgatagtgat   646200
acaacgattt cggttgtcga agtctatgtt tcaaaagtcc gtaagaaatt aaagggaacc   646260
acttttgcag agaatttgca aactttgcgt agtgttgggt atcttttaaa agatgttcag   646320
taaacttaaa aaaacatggt atgcggatga ctttagttat tttatccgca acttcggtgt   646380
cttcaccctg attttttcta caatgactct gattatttta caagtcatgc attcgagtct   646440
ttatacttcg gtggacgata agcttcatgg actgagtgaa aatcctcaag cagttattca   646500
gctggctata aatagggcaa cagaagagat taaagattta gaaaatgcta gggcggacgc   646560
tagtaaagta gaaataaaac ctaatgtcag ttccaatacg gaagtcattc tctttgataa   646620
agactttact caacttcttt ctggaaatcg atttttgggc ttggataaga ttaagttaga   646680
aaagaaagaa ctaggacata tctaccagat tcaggttttt aatagctatg ggcaggaaga   646740
aatctatcgt gtgattttga tggagaccaa tattagttcg gtttcaacca atatcaagta   646800
tgctgctgtc ttgattaata ccagtcagtt ggaacaggct agtcaaaagc atgagcaatt   646860
gattgtggtc gtgatggcta gtttctggat tttgtcttta cttgccagtc tctatctagc   646920
tagggtcagt gttaggcccc tgcttgagag tatgcagaag caacagtctt ttgtggaaaa   646980
tgccagtcat gagttacgaa ctccactcgc agttttgcaa aatcgcttag agaccctttt   647040
tcgtaagcca gaagctacca ttatggatgt gagcgaaagc attgcatcga gtttggaaga   647100
agtccgaaat atgcgttttt taacgacaag cttgctgaac ttagctcgga gagatgatgg   647160
gattaagccg gagcttgcag aagttccaac tagctttttt aatacaactt tcacaaacta   647220
cgagatgatt gcttcggaaa ataatcgtgt cttccgtttt gaaaatcgta tccatcgaac   647280
aattgtcaca gatcagcttc ttctgaaaca actgatgacc attcttttcg ataatgccgt   647340
caagtatact gaggaggatg gtgaaattga ttttcttatc tcggcgaccg atcgcaatct   647400
ttatttactt gtttctgata atggaatcgg tatttcgaca gaagataaaa agaaaatttt   647460
tgaccgtttt tatcgagtag acaaggctag aacccggcaa aaaggtggtt ttggtttagg   647520
attatcccta gccaagcaaa ttgtagatgc tctaaaagga actgttactg tcaaagataa   647580
taaacccaag ggaacaatct ttgaagtgaa gattgccatt cagacaccat ctaaaaagaa   647640
aaaataaaaa tatcgctcca attggggcga tattttggat ttatcttcta cgttttcgtt   647700
tgataataga ccgttgaact tttaaaacaa gtaagctgaa tccgattgct gcggcaaagg   647760
caagagcagt tgataatttt aatgctaaaa agataaaact aaagatagca atacagatac   647820
aaaaaacagc gatattaata aaaaatagga tttccttgag attggcatca gattgcgctt   647880
caggtgtata agcttggtaa tgaggaagct gctggtttaa ttcttcttga tagtctacct   647940
cataggattg taattttctt acgggcatga ttctctcctt aacagtacat acctatttta   648000
tcattttttc ggcagagaat tattacagaa aggttacaaa aagaataaag tcccttttca   648060
ttttcaaagc atggctgatt ttggagaaat gtggtataat ttttcttatg gaaaagattg   648120
tcattacagc aactgctgaa agtattgaac aagttgaaca actactcgaa gctggcgtag   648180
accgtatcta tgtcggtgag aaagattttg gtcttcgtct gccaacgacc tttagttatg   648240
accaattacg tgaaatcgct aagttggttc atgatgctgg taaggaattg atcgttgcgg   648300
tcaatgctct catgcaccaa gatatgatgg accgtatcaa gcctttctta aacttcttgg   648360
aagaaatcaa gacagactat attacgattg gggatgcagg cgtcttttac gtagttaacc   648420
gcgatggtta ttcatttaag accatctacg atgcttcaac catggtaact agcagtcgtc   648480
agattaactt ctggggacaa aaggctggcg catctgaggc tgttttggcg cgtgaaattc   648540
catcagctga acttttcaaa atgccagaga ttttggaaat tcctgctgaa gttttggttt   648600
acggtgctag cgtcatccat cattctaaac gtccactctt gcaaaactac tataacttta   648660
cacatatcga tgatgaaaag acgcataaac gtgacctctt cttggctgag ccaagtgatc   648720
cagagagcca ctattccatt tttgaagata atcatgggac ccatatcttt gccaacaatg   648780
accttgattt gatgatcaaa ttaacagaat tggtggagca tggctttact cgctggaaac   648840
tagaagggct ctacactcct ggtcagaact ttgttgagat tgcaaaactc tttatccaag   648900
cgcgtagctt gattcaagag ggcaacttta gtcatgctca agccttcttg ctggatgaag   648960
aagttcgtaa acttcaccct aaaaaccgtt tccttgatac aggattttat gactacgatc   649020
ctgacatggt tagataaaat acatgattcg ttgagagaag gaagatgcaa acatttcttc   649080
tctcaatttt tcgtatttct tcactatttt acaaaaatca gcaggctaga atgctctatt   649140
cgatgggatt tttaagaaaa gtagtgttct tgagtttgaa aattatccta tgtttgcagg   649200
tgccaaatgg cccttttttt ggtataattt tttataatga aaacgattgg taatcgctat   649260
gttgtggtgg atttagaggc aactagcaca ggtagtaagg ctaaaattat ccaagtggga   649320
attgtcgtga ttgaggacgg agaaatcgtc gatcactata cgacggatgt caatccacat   649380
gaacccttgg atgctcatat caaagaactg acaggattga cagaccaacg tctggcgcaa   649440
gcacctgatt tttcgcaagt tgccagaaaa atatttgact tggtggagga tgggattttt   649500
gtagcccata atgttcagtt tgatgctaat ctcttggcgg aaaatttatt ttttgaaggc   649560
tatgagctaa gaaaccctcg tgttgatacg gtcgaattgg cccaggtctt tttccctgaa   649620
ctggaaaaat atagcttgcc gattttgtgt cgagaattag gaattcctct taaacacgca   649680
cacacagccc tttcagatgc ccaagctaca gcagaattac ttcttttttt acggaaaaag   649740
atgacccagc ttcctaaagg tctcttggaa cgcttgctgg aaatggctga cgctctccta   649800
tatgagtcct acctggttat tgaggaaact tatcgcaacc aatctatcct gagttctcca   649860
gacttggtcc aagttcaagg tctatatttt aagaaaacgg aagcttctct ggagccacga   649920
aaactatctc aagacttttc taaaaatatt tctctgttga accttgaagt gagggaggaa   649980
caagaaagtt ttgctaaaga ggttggcttg ctattgaaag atgaacctgt ctctctgatt   650040
caagcgccga cagggattgg gaaaacctat ggctatctct tacccgcttt atctcaatcc   650100
aaagagcgac aaattgttct tagtgttccg acaaagattc ttcaaaatca aatcatggaa   650160
gaagaaggta aacgcctcaa ggaagtgttc catacagata ttcatagctt aaagggacca   650220
caaaattatc tgaagttgga tgccttttat cattccttgc aggaaaatga tgaaaatcgc   650280
ttatttagac gctttaaaat gcaagtcttg gtctggctta ctgagacaga gacaggagat   650340
ttggatgaaa tcgggcaact ctaccgttac caacattttc tagcagacct tcgtcatgat   650400
gggaatttat catcccagag cttatttgtg acggaagatt tttggaaacg tagtcaagaa   650460
agggcagaga cttgcaagct tttagtgact aatcatgcct atctcgtaac cagacttgaa   650520
gataatcctg aatttgtcag tgaccgttta ctgattattg atgaagtcca aaagattttg   650580
ttagctctag aaaatctgct tcaagagacc tacgatatac aatctattat cgatttaatt   650640
gataaggctt tagtaggaga agaaaacagg gttcaacaac ggatactaga aagtattcgc   650700
tttgagtgtc tctacttgat agaacaattt cagtctggca aatctaggaa aaatatctta   650760
gattctctgg acaatctcca tcagtatttt tcagaattgg aagtagaaga ctttgatgag   650820
ctggttcgct attttacagc tgaaggtgat tactggcttg aagtaactga aacgagtcaa   650880
aagaaaattc agatttcttc tacaaaatca ggccgtactc ttctgtcctc tttacttcct   650940
gagagttgcc aagtcttggg agtatcggct actcttgaga ttagtcagag ggtttctttg   651000
gcagaccttt taggctatcc tgaagctaaa tttgtcaaga ttgaatctcg gggaaaacag   651060
gaacaagaag tggtcatggt caaagatttc cctctggtaa cagaaacctc cttagaagtc   651120
tatgccagag aggtagctgc tttactagtg gaaattcaag ctttccagca accgattttg   651180
gttctcttta ccgctaaaga catgcttcta gcagtatcgg atttacttac agttagccac   651240
ttggcccagt ataaaaatgg ggatgttcat cagctaaaga aacgctttga aaaaggtgaa   651300
caacaaatct tgcttggtgc agcaagtttc tgggagggag ttgatttttc aagccatcct   651360
tctgtgattc aagttgtacc gaggcttcct ttccaaaatc ctcaagaacc cttgacgaaa   651420
aagattaatc aagaactgaa tcaagaaggg aaaaatgcct tttatgatta tcaattgcca   651480
atggccatta ttcgtttaaa acaggctttg ggaagaagta tgagacgtga ataccaacgt   651540
tccttaactc ttattttgga taggagaatc gtcggaaaac gatacggcaa acaaatagta   651600
gcatctctag cagaagaagc gactgttaaa accatctctc gatccgaagt tgacgaggct   651660
attgatagat tttttaatga gctttgataa atagtattgt atgaaagtat aaggttagta   651720
tatatgaaac gttctctcga ctcaagagtc gattacagtt tgctcttgcc agtatttttt   651780
ctactggtca tcggtgtggt ggctatctat atagccgtta gtcatgatta tcccaataat   651840
attctgccca ttttagggca gcaggtcgcc tggattgcct tggggcttgt gattggtttt   651900
gtggtcatgc tctttaatac agaatttctt tggaaggtga ccccctttct atatatttta   651960
ggcttgggac ttatgatctt gccgattgta ttttataatc caagcttagt tgcatcaacg   652020
ggtgccaaaa actgggtatc aataaatgga attaccctat tccaaccgtc agaatttatg   652080
aagatatcct atatcctcat gttggctcgt gtcattgtcc aatttacaaa gaaacataag   652140
gaatggagac gcacggttcc gctggacttt ttgttaattt tctggatgat tctctttacc   652200
attccagtcc tagttctttt agcacttcaa agtgacttgg ggacggcttt ggtttttgta   652260
gccattttct caggaatcgt tttattatca ggggtttctt ggaaaattat tatcccagta   652320
tttgtgactg ctgtaacagg agttgctggt ttcttagcta tctttattag caaggacgga   652380
cgagcttttc ttcaccagat tggaatgccg acctaccaaa ttaatcggat tttggcttgg   652440
ctcaatccct ttgagtttgc ccaaacaacg acttaccagc aggctcaagg gcagattgcc   652500
attgggagtg gtggcttatt tggtcaggga tttaatgctt cgaatctgct tatcccagtt   652560
cgagagtcag atatgatttt tacggttatt gcagaagatt ttggctttat tggctctgtc   652620
ctggttattg ccctctatct catgttgatt taccgtatgt tgaagattac tcttaaatca   652680
aataaccagt tctacactta tatttccaca ggtttgatta tgatgttgct cttccacatc   652740
tttgagaata tcggtgctgt gactggacta cttcctttga cggggattcc cttgcctttc   652800
atttcgcaag ggggatcagc tattatcagt aatctgattg gtgttggttt gcttttatcg   652860
atgagttacc agactaatct agctgaagaa aagagcggaa aagtcccatt caaacggaaa   652920
aaggttgtat taaaacaaat taaataagga gaaaatcatg gtaaaagtag cagttatatt   652980
agctcagggc tttgaagaaa ttgaagcctt gacagttgta gatgtcttgc gtcgagccaa   653040
tatcacatgt gatatggttg gttttgaaga gcaagtaacg ggttcgcatg caatccaagt   653100
aagagcagat catgtctttg atggagattt atcagactat gatatgattg ttcttcctgg   653160
aggtatgcct ggttctgcac atttacgtga taatcagacc ttgattcaag aattgcaaag   653220
cttcgagcaa gaagggaaga aactagcagc catttgtgcg gcaccaattg ccctcaatca   653280
agcagagata ttgaaaaata agcgatacac ttgttatgac ggcgttcaag agcaaatcct   653340
tgatggtcac tacgtcaagg aaacagtagt ggtagatggt cagttgacaa ccagtcgggg   653400
tccttcaaca gcccttgcct ttgcctacga gttggtggag caactaggag gggacgcaga   653460
gagtttacga acaggaatgc tctatcgaga tgtctttggt aaaaatcagt aaaacgggag   653520
ttattctctc gttttttatg tggaaaactc agggaaatca tcgctttttt cataaaaaaa   653580
tgctataatg aagggtatga aatatcacga ttacatctgg gatttaggtg gaactttact   653640
ggataattat gaaacttcaa cagctgcatt tgttgaaaca ttggcactgt atggtatcac   653700
acaagaccat gacagtgtct atcaagcttt aaaggtttct actccttttg cgattgagac   653760
attcgctccc aatttagaga attttttaga aaagtacaag gaaaatgaag ccagagagct   653820
tgaacacccg attttatttg aaggagtttc tgacctattg gaagacattt caaatcaagg   653880
tggccgtcat tttttggtct ctcatcgaaa tgatcaggtt ttggaaattt tagaaaaaac   653940
ctctatagca gcttatttta cagaagtggt gacttctagc tcaggcttta agagaaagcc   654000
aaatcccgaa tccatgcttt atttaagaga aaagtatcag attagctctg gtcttgtcat   654060
tggtgatcgg ccgattgata tcgaagcagg tcaagctgca ggacttgata cccacttgtt   654120
taccagtatc gtgaatttaa gacaagtatt agacatataa gaaaaaggaa taagatgaca   654180
gaagaaatca aaaatctgca ggcacaggat tatgatgcca gtcaaattca agttttagag   654240
ggcttagagg ctgttcgtat gcgtccaggg atgtacattg gatcaacctc aaaagaaggt   654300
cttcaccatc tagtctggga aattgttgat aactcaattg acgaggcctt ggcaggattt   654360
gccagccata ttcaagtttt tattgagcca gatgattcga ttactgttgt ggatgatggg   654420
cgtggtatcc cagtcgatat tcaggaaaaa acaggccgtc ctgctgttga gaccgtcttt   654480
acagtccttc acgctggagg aaagttcggc ggtggtggat acaaggtttc aggtggtctt   654540
cacggggtgg ggtcgtcagt agttaatgcc ctttccactc aattagacgt tcatgttcac   654600
aaaaatggta agattcatta ccaagaatac cgtcgtggtc atgttgtcgc agatcttgaa   654660
atagttggag atacggataa aacaggaaca actgttcact tcacaccgga cccaaaaatc   654720
ttcactgaaa caacaatctt tgattttgat aaattaaata aacggattca agagttggcc   654780
tttctaaatc gcggtcttca aatttcaatt acagataagc gccaaggttt ggaacaaacc   654840
aagcattatc attatgaagg tgggattgct agttacgttg aatatatcaa cgagaacaag   654900
gatgtaatct ttgatacacc aatctataca gacggtgaga tggatgatat cacagttgag   654960
gtagccatgc agtacacaac tggttaccat gaaaatgtca tgagtttcgc caataatatt   655020
catacccatg aaggtggaac acatgaacaa ggtttccgta cagccttgac acgtgttatc   655080
aacgattatg ctcgtaaaaa taagttactg aaagacaatg aagataattt aacaggggaa   655140
gatgttcgcg aaggcttaac tgcagttatc tcagttaaac acccaaatcc acagtttgaa   655200
ggacaaacca agaccaaatt gggaaatagc gaagtggtca agattaccaa tcgcctcttc   655260
agtgaagctt tctccgattt cctcatggaa aatccacaga ttgccaaacg tatcgtagaa   655320
aaaggaattt tggctgccaa ggctcgtgtg gctgccaagc gtgcgcgtga agtcacacgt   655380
aaaaaatctg gtttggaaat ttccaacctt ccagggaaac tagcagactg ttcttctaat   655440
aaccctgctg aaacagaact cttcatcgtc gaaggagact cagctggtgg atcagccaaa   655500
tctggtcgta accgtgagtt tcaggctatc cttccaattc gcggtaagat tttgaacgtt   655560
gaaaaagcaa gtatggataa gattctagcc aacgaagaaa ttcgtagtct tttcacagcc   655620
atgggaacag gatttggcgc agaatttgat gtttcgaaag cccgttacca aaaactcgtt   655680
ttgatgaccg atgccgatgt cgatggagcc cacattcgta cccttctttt aaccttgatt   655740
tatcgttata tgaaaccaat cctagaagct ggttatgttt atattgccca accaccaatc   655800
tatggtgtca aggttggaag cgagattaaa gaatatatcc agccgggtgc agatcaagaa   655860
atcaaactcc aagaagcttt agcccgttat agtgaaggtc gtaccaaacc gactattcag   655920
cgttataagg ggctaggtga aatggacgat catcagctgt gggaaacaac catggatccc   655980
gaacatcgct tgatggctag agtttctgta gatgatgctg cagaagcaga taaaatcttt   656040
gatatgttga tgggggatcg agtagagcct cgtcgtgagt ttatcgaaga aaatgctgtc   656100
tatagtacac ttgatgtcta aaaaataggg agaagtagtt cccttggtct aaaaaatatg   656160
atataatcgt tacgattgtt tcaagtaaaa aaggagtttg atatgtctaa tggacaacta   656220
atttatttaa tggttgcaat tgcagtcatt ttagttctgg cttatgtagt ggcaatcttt   656280
ctacgtaagc gaaacgaggg gagattagag gcgctagaag aaaaaaaaga agaactatac   656340
aatcttccag taaatgatga agtagaagct gtaaaaaata tgcacttgat tggacaaagt   656400
caagtggctt tccgtgaatg gaatcaaaaa tgggtcgatt tatctctcaa ctcttttgcc   656460
gatattgaaa ataatctctt tgaagcagaa ggctataacc attcatttcg ttttctcaag   656520
gccagtcatc aaattgacca aattgagagt caaattactt tgattgaaga agatattgcg   656580
gcaattcgca atgctttggc agacttagag aagcaagaat ctaaaaatag tggtcgtgtt   656640
cttcatgctt tggatttatt tgaggaactt cagcatagag ttgctgaaaa ttcagaacag   656700
tatggtcaag ccttggatga aattgaaaaa caattagaaa atatccaatc tgaattttca   656760
caatttgtaa ccttgaattc atcgggtgac cctgtggaag ccgcagtgat tttggataat   656820
acagaaaatc acattttggc cttaagtcat attgtggatc gtgttccagc cttggttacg   656880
acgctttcta cagaattgcc agatcaatta caggatttgg aagccggtta tcgtaaacta   656940
attgatgcta attatcattt tgttgaaacg gatattgaag cgcgtttcca cttgctttat   657000
gaagcattca agaaaaacca agagaatatt cgtcagttgg aattggataa tgccgaatat   657060
gagaatggac aggcacaaga ggaaatcaat gccttgtatg atatttttac tcgagaaatt   657120
gctgctcaga aagtagtgga aaatctactt gcaactcttc caacttatct tcaacatatg   657180
aaagagaata atactttatt gggagaagat attgcacgtt tgaacaagac ctatttactt   657240
cctgagacag ctgcaagcca tgttcgtcgt attcagacag aattagagag ttttgaggca   657300
gctattgttg aggtaacttc aaatcaagaa gaaccaaccc aagcttattc agttcttgaa   657360
gaaaatcttg aggatttaca aactcaacta aaagatattg aagatgagca aatttcagtt   657420
agtgagcgcc tgacacaaat tgagaaagat gatattaatg cacgtcaaaa ggccaatgtt   657480
tatgtcaatc gtctccatac tatcaagcga tacatggaaa aacgcaatct gccaggtatt   657540
ccacaaactt tcttgaagtt attctttacg gcaagcaata ataccgagga tttaatggtt   657600
gagttagaac aaaaaatgat taacattgaa tctgttaccc gagttcttga aattgcaacg   657660
aatgatatgg aagctttaga aacggaaact tataatattg tacaatatgc aactttgaca   657720
gagcaactct tgcaatattc taaccgctat cgctcatttg atgaacgcat tcaagaagca   657780
tttaacgaag ctttagatat ttttgaaaaa gaatttgatt atcacgcttc atttgacaag   657840
atttctcaag cattggaagt ggcagagcct ggtgtaacca atcgctttgt tacctcatat   657900
gagaaaacac gtgaaacgat tcgtttttaa taaaagaaaa agattttatt gtgtgaggag   657960
cagaatcaaa tctttttcta tagttgtggg gagatttact tcattttctc ctgagattga   658020
gtttttgccc agccgattta tccactacct caaaacagtg ttttatactc ttcgaaaatc   658080
ttttcaaatc acgtcagcgt cgccttaccg tactcaagta cagcctgagg ctagcttctt   658140
agtttgcttt ttgattttca tttagtatta aagtgatttc gccagtctta tctgcagctt   658200
caaatctgta ctttgagtaa cttggtaacc gtccaataac gaagtctatt gaaaaatctc   658260
cagactagag aactcacgga tagttcctaa tctggagatt tcttatttgc acttttcttg   658320
tacaacttta gtccacggta aatagacctc taaaacctct ttgtttacga gagtttcctc   658380
gtttggaaga cattctagaa gataggatag atatttctcg ctatttatac tagactaaaa   658440
tcaaaaagca ttatataata gtgatatgaa atcaactaaa gaagaaatcc aaaccatcaa   658500
aacactttta aaagactctc gtacagctaa atatcataaa cgccttcaaa tcgttctata   658560
gtaaaatgaa ataagaacag tacaaatcga tcaggacagt caaattgatt tctaacaatg   658620
ttttagaagt agaggtgtac tattctagtt tcaatctatt atatttcgtc tgatgggcaa   658680
atcttataaa gagattatag aacttttata gtagattgaa ataagatgtg aacaactcta   658740
tcaggaaagt caaattaatt tatagaaata ttttagcagc caaggtgtac tgttatagat   658800
tcaatacact atagactgta atcaaacaac gatttggcga aatgtaaaaa aatatgagga   658860
gttcggactc gactctctcc ttcaagaaac acgtggtggt cgtaaccatg catatatgac   658920
agttgaggaa aagaaagtct ttcttgcccg ccatttgaag gctgcagagg caggagaatt   658980
tgttacaatt gatgccttat ttcaggctta taaaaaggag ttaggtcgtt cctacacacg   659040
tgatgccttc tatcaactgt tgaagtgcca tggttggcga aatattatgc cacgtccaga   659100
acatcctaag aaagcagacg ctcaaaccat tgtcgcgtct aaaaataaaa tctcaattca   659160
agaagaaaag aaagcgcttt aaaaccagta gacgttttcg taaggttcgc ttgatgtacc   659220
aagatgaggc tggtttcggt agaatcagta aactgggatc ttgttgggct ccaataggag   659280
taggtccaca tatccatagt cactatatac gagaatttcg ctattgttat ggagctgttg   659340
atgcccatac aggcgaatca tttttcttaa tagctggtag atgtaatact gagtggatga   659400
acgccttttt agaagagctt tcacaagctt atccagatga ttatctttta ctcgttatgg   659460
acaatgctat atggcataaa tcaagtacct taaagattcc gactaatatt ggttttacct   659520
ttattcctcc atacacacca gagatgaacc ccattgaaca agtgtggaaa gagattcgta   659580
aacgtggatt taagaataaa gcctttcaaa ctttggaaga tgtcatgaat caactccaag   659640
atgttataca aggattggag aaggaggtga taaagtccat cgttaatcgg agatggacta   659700
gaatgctttt tgaaaacaga tgagtataaa aagaaagtcc tcatttcaat agaaatcacg   659760
actttctgat ggatttatag taaaatgaaa taagaacagg acaaatcgat caggacagtc   659820
aaatcgattt ctaacaatgt tttagaagca gaggtgtact attctagttt caatctacta   659880
tatttttgga gtgatagaaa agcccttcat aagctagtct acttgttcag gtgcgagagc   659940
tttgacatct ttttctgtac ttagccaagt cagttttccg ttctcaaagc gtttatatag   660000
tagccaaaat ccttgaccat cccagtaaag ggctttaaag cggtctttac gtccaccaca   660060
aaagagaaag acttgaccgg agaaagaatc caattcaaag tgggttttaa ctacataggc   660120
taatgagtct attccctgcc tcatatctgt cttgccacaa acaaggtgaa cttgacctaa   660180
atcacttagt tgaattatca tagtacaata cctttcctcc gataattatt ttttatctag   660240
tatactggaa gttggggaat taggatagat accttgttat gacgcgctta cgtaacttgt   660300
aactagctgc ctagtttgat ctttgcttct tcattgatta gcagtagatt tcaaaatgat   660360
aaaaacgcat agtatcaggt attgaaatgt actgccccaa aagttagaca gaaaaaatct   660420
aacttttggg gtgtttttgt tatgaaatta agttatgatg ataaagttca gatctatgaa   660480
cttagaaaac aaggatatag cttagagaag ctttcaaata aatttgggat aaataattct   660540
aatcttaggt atatgattaa attgattgat cgttacggaa tagagttcgt caaaaaagga   660600
aaaaatcgtt actattttcc tgatttaaaa caagaaatga ttaataaagt cttacatgaa   660660
ggctgaacta aagatagagt ttctcttgaa tacggtctcc caagtcgtac gatacttctt   660720
aactggctag cacaatacag aaaaaacggg tatactattg ttgagaaaac aagagggaga   660780
gtacctaaaa tgggacgtaa gccaaaaaag agacctgaag agagaacaga attagaacgt   660840
cttcaagcag aaaatgagta cctgagagcg gagaatgcta tcctaaaaaa gttaagagaa   660900
ctccgatgga aggaggaaaa agagaaagaa gaaagacaga aattgttcaa gaattaatga   660960
ctgagttttc gttagatctt cttctaaaag ccattaaact agctcgttgg acctactact   661020
atcacttgaa acagctagac aaaccagata aggaccaaga gcttaaagct gaaattcaat   661080
ccatttttat cgaacacaag ggaaattatg gttatcgtcg gatttattta gaactaagaa   661140
atcgtggtta tctggtaaat cataaaagag ttcaaggctt gatgaaagta ctcaatttac   661200
aagctaaaat gcgacagaaa cgaaaataaa ggagacgttg gtaagaaggc agagaatctc   661260
attcaaggcc aatttgaagg ctctaaaaca atggaaaagt gctacacaga tgtgacagaa   661320
tttgccattc cagcaagtac tcaaaagctt tacttatcac cagttttaga tggctttaat   661380
agcgaaatta ttgcttttaa tctttcgact tcacccaact tagaacaagt acaaacaatg   661440
ttagaacagg cattcaaaga gaagcactac gagaatacga ttctccatag tgaccaaggc   661500
tggcaatatc aacacgattc ttatcatcgg ttcctagaga gtaagggaat tcaagcatct   661560
atgtcacgca agggcaacag ccaagacaac ggtatgatgg aatctttctt tggcatttta   661620
aaatccgaaa tgttttatgg ctatgagaaa acatttaaat cacttaacca attggaacaa   661680
gccattatag actatattga ttactacaac aacaaacgaa ttaaggtaaa actaaaagga   661740
cttagtcctg tgcagtacag aactaaatcc tttggataaa ttaattgtct aactttttgg   661800
ggtcagtaca aaactcttgc tactatgcgt tttattattg aaagacttat tggactttct   661860
ctcaaatcga gtttttactc aattttctta cttgattggg attgaaattc caattaattt   661920
ctctgagtag agtgtcttga tattggcttc atcaacagag gccttatcaa ttttacgttt   661980
caagaaaaat tcttgaatgg tttcgatttc aggctcacga atagcacggt gtttgtttga   662040
gatgaggatt tcatagtgaa gcggagcttg ggtaaaaata acatctgtat tccctgcaga   662100
ataaacctca acaagggttg catcggtact ttctagctga ctttttacaa gttgcgagtg   662160
tgagtttgtc gtattgataa gcttcataat atttcctccg attttctaat tctattatag   662220
cactttttga ataaagtcgc ttgatttata ctcaatgaaa atcaaagagc aaactaggaa   662280
gctagccgca ggctatactt gagtacggta aggcgacgct gacgtggttt gaattttatt   662340
ttcgaagagt attagccaat cttatgctgt tttttccaag attcaatggc ccatttatgg   662400
ctaccacgtt taaggttttt gatagcctcg tcaataggga accaggcaat atgattaaag   662460
ttttctagtg gcttttgtac ttctttgaaa ggagttgctt catagaggta ggcaggattg   662520
tagtagtagg tatcacgatg acgagaatag aaatattcgt cagcttgtcc gtaataggta   662580
ccaatttctg ctgtgaaacc aagctcttca atcaactcat gctttagggc ttcctgatga   662640
ttttcacctg cttcaatttc tccacatggt aggaaccaag caccatttgg ttcttgaaca   662700
agaacaattt gtttttgttc aggattaggg ataactgcat atacgccata gcgagcaata   662760
tagtctgtat tcactttttt tctccgaaag ttgggtttgc cattgcattt tcctcattat   662820
ctagtatcgt tattattata gtgaaatgaa ccaaaaatag tacacaatgt ggtataatct   662880
tcttatggca tattcaatag attttcgtaa aaaagttctc tcttattgtg agcgaacagg   662940
tagtataaca gaagcatcac acgttttcca aatctcacgt aataccattt atggctggtt   663000
aaagctaaaa gagaaaacag gagagctaaa ccaccaagta aaaggaataa aaccaagaaa   663060
ggttgataga gatagactta aaaactatct tactgacaat ccagacgctt atttgactga   663120
aatagcttct gaatttggct gtcatccaac taccatccac tatgcgctca aagctatggg   663180
ctacactcga aaaaaaaaag aactacacct actatgaaca agacccagaa aaagtagcct   663240
tatttcttaa gaattttaat agtttaaagc acctagcacc tgtttagatt gacgaaacag   663300
gattcgatac ttatttttat cgagaatatg gtcgctcatt aaaaggtcag ttaagaagag   663360
gcaaagtatc tggaagaaga tatcagagaa tttctttggt tgcaggtcta acaaatgaat   663420
ggtgagttaa tcgctccaat gacttacgaa gagacgatga cgagcgactt ttttgaagct   663480
tggtttcaga agtttctctt accaacatta accacaccat cggttattat tatggataat   663540
gcaagattcc atagaatggg taagttagaa ctcttgtgtg aagagtttgg gtataaactt   663600
ttacctcttc ctccctactc acctgagtac aatcctattg agaaaacatg ggctcatatc   663660
aaaaagcacc tcaaaaaggt attaccaagt tgcaatacct tttatgaggc tcttttgtct   663720
tgttcttgtt tcaattgact atagcagatt gaaataagat gagaacaaat cgattgggaa   663780
agtaaaatta atttctataa atgttttagc aattgtttcg tactatttca gattcagtct   663840
actatatatc ataatggaca aagggcaagc tgtcaagaaa ttacagttat tttagtaaaa   663900
aaagaagcag aaaaatttca ttttctactc cttttttata ggatttattt ttctttttca   663960
gaacttttaa cttcagcttt tttggcagat ttaatctgaa tgtttccctt gctagtcata   664020
actgctttga gatctttttc gcttggattt tcaaggtagt agtcagtgat tgtgtcctca   664080
atatagtctt gaatagtccg acgaagtggg cgtgctccca tttttggatc ataacctagg   664140
tcaaccaact tttccttgac cttatcagtt acatccaaac gaatgttgtt gctagagagg   664200
cgcttgttaa catctgctag catgagctcg acaatctgaa ggaggttatc cttgctgaga   664260
gccttaaatt cgataatgcc atcaaaacgg ttcataaact ctgggctaaa gaagttaccg   664320
agttcaccga ggacagaatt ggtacgtcct tctctagcag caccaaatcc aacgctagct   664380
tcggtctttc ctgtacctgc atttgaggtc atgataatga tggcatcctt gaagctaacg   664440
gtgcgtcctt gcccgtctgt caaacgacca tcgtccaaga cttgaagaaa catgtgcata   664500
acatctgggt gagctttttc cacttcatcg agaaggatga gagaatatgg attgtggcga   664560
actttttcag ttaattgacc agcctcatca tagccaacat aacctggagg agcgccgacc   664620
aacttagcca cactatgttt ttccatgtat tcactcatat caaagcgaat catactatca   664680
gcagaaccaa aaagttcgat agccagttgt ttggaaagtt ctgtcttacc gacaccagtt   664740
ggcccaacga agaggaagct tccgattggg cggttagggg taccaagtcc gacacgatta   664800
cggcgaatag ccttggcaat cttatcgact gcatcatctt gaccaataac atgagacttg   664860
agatcttcgg ctagatggat gagttgagat tgttctttct ctttcaaatc accaacaggg   664920
atattggttt tctgctcgat aatgtgctca atagttttct cgctgatgct aggagtatcc   664980
tggtctgtga tctttttctt ttgcatttcc ttatacttgg caatctggtc gcggaagtag   665040
gccgccttct caaaatcttc ttctcgtgta gcttgagact tgagattttc agcctcaatc   665100
aagcgctgat caattacttt aggatccaca aaattcaagg tcaagttcat cttagaacca   665160
gcttcatcta ggaggtcaat ggccttgtca ggcaagaagc gatcttggat gtagcgattg   665220
gaaagagttg cagctgcttc aatcgcagca tctgtatatt gaacgtggtg gtaatcttcg   665280
tatttctttt gaatcccttt gagaatagtg attgtttcgt ccaccgttgg ttcatcgact   665340
ttaacaggct gcatacgacg ctcgagggca gcatcctttt caatgatacg gtattcattg   665400
agggtagtag caccgactag ttgcagttct ccacgagcaa gggctggctt gaggatattt   665460
cctgcgtcca tattaccatc actcgcagaa ccagcaccaa caatttcatg gatttcatcg   665520
ataaagagga tgatgtcttc acgtttgcga atttcttcca tgagtttttg catgcgttct   665580
tcaaattgtc ctcgaatccc cgttccttga actaagctaa ccacatccag acggatgact   665640
tgtttacctt ggagtttatg tggcacatcg ccatcgacaa ttttctgagc tagaccttcg   665700
acaacggccg tttttccgac accaggttca ccgataagga caggattatt cttggttcta   665760
cgattgagaa tctcgatgac acggataatc tcatcgtcgc gcccaataac ggggtcaatg   665820
tctccacgac gggcaatttc agttacatta ataccaaatt cttccagcag gcctttttct   665880
tggctaggtg gcggagtttg agcagatcca cgattttggg aaccataacc gccgtttcca   665940
ccgtaacctc cacctgattg ggttggggga ataggaggag tattgctaga aggtctgaaa   666000
ttgtttagat cattgaagaa atcaccaaag ggatcgaagt cacgattgtt cagatccgtc   666060
atacctttga agaggctatt gttaggatct gttttgataa tcttatagca gttttgacag   666120
aggtcaattt gtttttgttt tccattgaga ttggtgtaaa gatgaattgt tgagtcgtta   666180
attttacagt tttgacaaag catacatcta cctcatttct ttctttagcc tgacttgttt   666240
aaaggtcaaa aatagtcaaa ttctatactc tcattataac aggattgggg tgtaaagcaa   666300
gtaaaaagat tgaagctttg agaagttgtt acaatgaaaa tttttgtgaa tttggactat   666360
aaaaaaatcc tatttgtgag acaaaaagga ttttacttag acatgcaggg acaatcccag   666420
cttgttttag attagtagag aagttcgtaa atttccattg cgattaagtc aatgctatca   666480
aacgtatacg tttcgcgatc ttctacgtca cgaagggtaa agattgggcc gttttcttcg   666540
tcgtggctgt acgcaacttc tgcaacaaca actccttcgc gttcaaaatt acgttttaaa   666600
tttccgccat cgtttgccat tgcttcaagg cggttgatga ttctaaccaa atgtgattcc   666660
attttgattc tccttcattt cttatcgtta ctattttacc ataaaggagg ccaacttgac   666720
tagaaaaaac taagatttct cgctaattct gctagtttaa atatttttaa ataaattgga   666780
taaaaaattt aaattttaat tcaaaacatg ttataatcat acagtattct attttagaaa   666840
gcagtgtgac tatgaatttt tcttttttac ctaagtattt accttatttt aactatgggg   666900
ctgttgtgac gattcttatt tctatctgtg ttatcttttt gggaactatt ttgggtgttg   666960
tcttggcttt tgggcaacgt tcaaagttta aaccgcttgt ttggttggcc aacttgtacg   667020
tttggatttt ccgtgggaca ccgatgatgg ttcaaattat gattgccttt gctcttatgc   667080
atatcaatgc tccgactatt cagattggaa ttttaggtgt tgatttttcg cgtctgattc   667140
cagggatttt gattatctct atgaatagtg gtgcttatgt ttcggagact gttcgtgccg   667200
gaatcaatgc ggttccaaaa ggtcagctag aagcggctta ttcgctaggg attcgtccta   667260
aaaatgcgat gcgttatgtg attttgccac aagcagtcaa aaatatcttg ccagcattgg   667320
ggaacgaatt tatcaccatt atcaaggaca gctccctctt atcagctatt ggggtcatgg   667380
agttgtggaa tggggctaca acagtttcta caacaaccta tctaccttta acaccacttt   667440
tatttgcagc attttactac ttgattatga cctctattct gacagtagcc ttgaaagctt   667500
ttgaaaaaca tatgggacaa ggagataaga aataatgaca gaaaccttga taaaaattga   667560
aaatttacat aaatcctttg gaaagaatga agtattgaag ggcatcaacc tcgagattaa   667620
aagaggagaa gttgtcgtta tcatcggtcc ttcagggagc gggaaatcta ccttgcttcg   667680
ctctatgaat ttgttggaag aagcaaccaa ggggaaggtt atctttgagg gagtcgatat   667740
tacggacaag aagaatgacc tgtttgccat gcgtgagaag atgggcatgg tttttcaaca   667800
attcaatctc tttcctaata tgactgtgat ggaaaatatc accttgtccc ctatcaagac   667860
caaaggtgac agtaaggccg ttgcagagaa aagagctcag gaacttttgg aaaaagttgg   667920
tttgccagat aaggcagacg cttatccaca gagtttgtca ggtggccagc aacagcggat   667980
tgccatcgcg cgtgggttgg ctatggaacc agatgttttg ctctttgacg agccaacttc   668040
agccctagat cctgagatgg ttggagaagt tctggctgtt atgcaagatc tagccaagtc   668100
aggaatgacc atggttatcg taacacatga gatgggattt gcccgtgagg tggcagatcg   668160
tgtcatcttt atggcagacg gtgtggttgt tgaagacgga acacctgagc agatttttga   668220
acaaacccaa ggacaaagga ctaaagactt cttgagtaag gttttataag ttagctttgt   668280
ttagctattt gtagccagct ttaaacgtta aagagaagat tagtgaaaag ctcaaccaga   668340
gctttttctt atagtttaaa gctataggat tgcctaggaa agaagtgtta gagctacatt   668400
gtattttttg gtataattaa agatatttgt aagaaaagag aagtgatatg acacagatta   668460
ttgatgggaa agctttagcg gccaaattgc aggggcagtt ggctgaaaag actgcaaaat   668520
taaaggaaga aacaggtcta gtgcctggtt tggtagtgat tttggttggg gacaatccag   668580
ccagccaagt ctacgttcgc aacaaggaga ggtcagccct tgcggctggt ttccgtagcg   668640
aagtagtacg ggttccagag accattactc aagaggaatt gttagacctg attgctaaat   668700
acaatcagga tccagcttgg catgggattt tggttcagtt gccattacca aaacacattg   668760
atgaagaggc ggttctattg gctattgacc cagaaaagga tgtggatggt ttccatcctc   668820
taaacatggg gcgtctttgg tctggtcatc cagtcatgat tccttcgaca ccggcaggaa   668880
ttatggaaat gttccatgaa tatgggattg acttggaagg taaaaatgca gtcgtcatcg   668940
gtcgatccaa tattgtcgga aaacctatgg cccagcttct tttggcaaag aatgcaacag   669000
taaccttgac tcactcacgt actcataatc tttccaaggt ggctgcaaaa gcagatattc   669060
tggttgttgc aatcggtcgt gccaagtttg tgactgctga ctttgtcaaa ccaggtgcgg   669120
tagtcattga cgttgggatg aaccgcgatg aaaatggtaa gctctgtggg gatgttgatt   669180
atgaggcggt tgccccactt gctagccaca ttacgccagt ccctggaggt gtcggtccta   669240
tgaccattac tatgctgatg gagcaaacct atcaggcagc acttaggaca ttggatagaa   669300
aataagataa aaattttctg aggaaagtgt attttctata gctatatcta aaatgataga   669360
aatgaatatt aaattttaga aataagttta taaaaggagg tttgcgcctc ctttttgttg   669420
tataatggag tgaggtgatt agatgatttt aaaaatttat aatggggaat atagtttaca   669480
atgggatgga atatactact tagcactaat tgattatcca aatattcaag agtgggaatt   669540
agaaaaaatt gctaaattta tagcttacga aaaacttcat aaacgtcaaa caagtattga   669600
gtgtgctgat tcttgtttaa aaaaagaaat tttagattac atctgtcagc atccctttct   669660
gccaccattt actcctacag ataaaagagt agcctcgact tatgacctac ataagaggtt   669720
agtgacttca gactactgta gtcatactac gactatagat gcagcgattt ctatttttaa   669780
aactggtcgt cttttatctg ctgtgaaagc ctttgggcga gatgctgagg agttggtttt   669840
ggatagtcga aatgctgcat ctgatccgat agattatttt gactatgtca tgttagggtg   669900
gtcaaataca agttctggtt atcgattggc gatggagcgt ttattaggtc gagctccttc   669960
agagaaagaa ttacaagaca agtttattcc tggagtaagt tttcatttta tctatacaga   670020
tttgattaaa gttcctggtt atatttttga tggttaccat gctgtaaaaa ttaaggacat   670080
gcttaattta ttaagtgagt tgtatatttg cattattcca actcataata agagccaatt   670140
tgaaaatatt attccaacca aaatacaaga tagggtgtat tatcttgact atgctggaga   670200
agacttagaa gagtggacta agaaagtcta tcaagttgtt ttaaaacaat cagataaagg   670260
atagttgagg aaaaaacgat gaaagtgatt gatcaaacct tactagaaaa agtcattatt   670320
gaacgttctt gtacaagtca taaaggagac tacggtcgtc tgctgttgct tggtgggact   670380
tatccttatg gtggtgccat catcatggct gctttagcag ctgtaaaaag cggtgcagga   670440
ttggtaaccg ttggaacgga cagggaaaat atccctgctc tacacagcca tttgcctgag   670500
gctatggcct tttctctgca agatcagtaa ttgttacaag agcaattgga gaaggcagaa   670560
gttgtcttgc tggggcctgg tttacgagac gatacgtttg gagaaaatct tgtaaaacag   670620
gtctttgcta gcttaaaaaa gaatcagatt ttgattgtag atggaggggc cttaaccatc   670680
cttgctagga caagtttgtt gtttccatct aaccagctta tcttaactcc ccaccaaaaa   670740
gaatgggaaa aactgtctgg tattgctatt gaaaagcaaa acgaaggtac aacatctagt   670800
gccctgactt ctttccctca aggaacaatt ttggtagaga aaggtccagc tactcgtatt   670860
tggcaagttg gccagtctga ttattaccag ttaaaggttg gcggtcccta tcaggcgact   670920
ggtggtatgg gtgatacact ggctggaatg attgcaggat ttgcaggcca atttcgacag   670980
gccagtctct acgaacgtgt ggcagtagca acccatcttc attcagccat agcccaagaa   671040
ctatctcaag aaaattatgt ggtcttgccg acggaaatta gtaattgtct tcctaaagta   671100
atgaaaagat atgtctaaaa tagttagaca aaaaatgttg ataatttgta tcattattct   671160
taattcacaa aaaacgaacg tttagtattc ttcttgctaa gaaactaaat ttgttcgttt   671220
ttttactctt gtaaatctat ttttgttaga gttgatttgg tttacatccg tacttaaatt   671280
gatttgttag agctctactt ttattaaaaa aattcaattt caaggataaa taagcagtat   671340
tctaaaggta cttttagatg aaataaaagc ctttacatgg tataatagag gtagctcttt   671400
aatggaggtg tttgagtgga aaatctgaag aaaatggcag gtatcacggc tgctgaattt   671460
atcaaggatg ggatggttgt agggctagga acaggttcta ctgcctatta ttttgtcgaa   671520
gaaatcggtc gtcgaatcaa ggaagaaggc ttgcagatta cagctgtgac gacttctagt   671580
gtgaccagta aacaggctga agggctcaat atcccgctca agtctattga ccaagtagac   671640
tttgtcgatg tgacagtcga cggggcggat gaagtggata gtcagtttaa tggaatcaaa   671700
ggcggtggtg gtgcccttct catggaaaag gtggtcgcaa caccatcaaa agaatacatt   671760
tgggtggtgg atgaaagcaa gctggtcgaa aaactaggtg cttttaaatt gccagtagaa   671820
gtggttcagt atggtgcaga gcaggtcttt cgtcattttg aacgagctgg ctacaaacca   671880
agtttccgtg aaaaagacgg ccaacgtttt gtgaccgata tgcagaattt tatcattgac   671940
ctcgccttgg atgtcattga aaatccaatt gcttttggac aagaattgga ccatgtcgtt   672000
ggtgttgtgg agcatggttt attcaaccaa atggtggata aggtaatcgt tgctggacga   672060
gatggagttc agatttcaac ttcaaaaaaa ggaaaataga agggggcata agatgtctaa   672120
atttaatcgt attcatttgg tggtactgga ttctgtagga atcggtgcag caccagatgc   672180
taataacttt gtcaatgcag gggttccaga tggagcttct gacacactgg gacacatttc   672240
aaaaacagtt ggtttgaatg tcccaaacat ggctaaaata ggtcttggaa atattcctcg   672300
tgaaactcct cttaagactg tagcagctga aagcaatcca actggatatg caacaaaatt   672360
agaggaagta tctcttggta aggatactat gactggacac tgggaaatca tgggactcaa   672420
cattactgag cctttcgata ctttctggaa cggattccca gaagaaatcc tgacaaaaat   672480
cgaagaattc tcaggacgca aggttattcg tgaagccaac aaaccttatt caggaacggc   672540
tgttatctat gattttggac cacgtcagat ggaaactgga gagttgatta tctatacttc   672600
agctgaccct gttttgcaga ttgctgccca cgaagacatt attcctttgg atgaattgta   672660
ccgtatctgt gaatacgctc gttcgattac ccttgagcgt cctgcccttc ttggtcgcat   672720
cattgctcgc ccttatgtag gtgaaccagg taacttcact cgtacggcaa accgtcgtga   672780
cttggctgta tctccatttt tcccaactgt tttggataaa ttgaatgagg ctggtatcga   672840
tacttatgct gtgggtaaaa tcaacgatat ctttaacggt gctggtatca accatgacat   672900
gggtcacaac aagtcaaata gtcatggaat tgatacacta ttgaagacta tgggacttgc   672960
tgagtttgaa aaaggattct cattcacaaa cctagttgac tttgatgccc tttacggcca   673020
tcgtcgtaat gctcacggtt accgtgattg cttgcatgag tttgatgaac gcttacctga   673080
aattatcgca gctatgagag agaatgacct tctcttgatt actgcggacc atggaaatga   673140
cccaacgtat gcaggaacgg atcacactcg ggaatatatt ccattgttgg cctatagccc   673200
tgcctttaaa ggaaatggtc tcattccagt aggacatttt gcagatattt cagcgactgt   673260
tgccgataac tttggtgtgg aaactgctat gattggggaa agtttcttag ataaattggt   673320
ataagatgac gcgctatgct ttgctggtga gaggtatcaa tgttggtggt aagaataagg   673380
tcgtcatggc ggagcttcgt caagaattga caaacttggg actggaaaag gttgagagct   673440
acatcaatag tggcaatatt ttctttactt cgatagattc caaagcccaa ttggttgaaa   673500
agctagagac tttctttgca gtccattatc catttattca gagcttttct ttactgagtc   673560
tagaggactt tgaggcggaa cttgaaaatc taccagcttg gtggagcaga gacttggcac   673620
gaaaagattt tctcttttac actgagggtt tggatgtgga ccaagtcatc gcgacagttg   673680
aaagtttaga gctgaaagat gaagtgcttt attttggaaa acttgggatt ttctggggga   673740
aattttctga agaatcctat tctaagactg cctatcataa gtacttgctg aaggtgcctt   673800
tctaccgcca cattactatt cgtaatgcta aaacctttga caaaattggt caaatgctaa   673860
aaaaataata aaggagacac acaatgacat ttttaaacaa aatccatgaa actgctactt   673920
tcctgaaaga aaagggaatt gcagcccctg agttcggtct aatccttgga tcaggacttg   673980
gagaattggc agaagaaatc gaaaatccag ttgtagtaga ctatgctgag attccaaact   674040
ggggccgttc aacagtagtc ggtcatgctg gtaaattggt atatggtgaa ctggcaggtc   674100
gcaaggtctt ggctcttcaa gggcgtttcc atttctatga agggaatcct ctggaagtgg   674160
tgactttccc agttcgtgtg atgaaagttc ttggatgtga aggtgttatt gtaaccaatg   674220
cagctggcgg tatcggattt ggtcctggta ccttgatggc tatctcagac catatcaaca   674280
tgacggggca aaatccattg atgggtgaaa acttggatga ctttggccca cgtttcccag   674340
atatgtctag ggcctacaca ccagaatacc gtgccactgc ccatgaagtg gctaaaaaac   674400
ttaatatcaa gcttgatgaa ggtgtctata tcggagttac tggtccgact tatgaaacac   674460
cagcagaaat tcgttcctat aagacactgg gagcagatgc agttggtatg tctacggttc   674520
ctgaagttat cgtggcagcc cactctggct tgaaagttct gggaatttca tgtatcacta   674580
actttgcggc cggtttccaa gaagaactca atcacgaaga agttgtagaa gtgactgaac   674640
gtgttaaagg tgatttcaaa ggcttgctta aagcgattct tgctgaattg taagaaaaaa   674700
gatttaaaag ggggagtgcc tctgtttttt caggattgac tgcctatccg gattaaagaa   674760
gaaacagagg aatactatga gcttcttcct gctcttataa ctgaaagaag cggaagaata   674820
ggtatgtctg atctgatagc cagcattgtg aaagacaaga ttctaggata ctagcattag   674880
cttcctagcc aagcagacta gtatgataag gagagatgag aatgaattga ctttctgaat   674940
ttctcagtct tatcatatat agcacaatga gatttcgctt gagtctgctt gtaaataaac   675000
gaaaagaaag ataagaaata atgaaaattg gtcaacgaat tatgcgcttt ggcataaaaa   675060
attaagtatc ggagttgtat ctgttgtagt cggctttgat ttctagctcc agctggaatt   675120
tcagccaatg aagtaaagca agatgtaaca tctgaagtgg taataggtgt gctagattct   675180
aaggaggaat tgaaagagtc agaaaatgat gctccaaaac tagaaactcc tcttagagag   675240
gagccaagac tagctcctca aacgcttccg gaagcaagtg aagttcttga aaacaaaagg   675300
gaagagtcaa aagtagagat aacataacca gctcaagcgg atgatatccg caaggttgtt   675360
ggggaattag ccaaggatat aagtattact aagttgtata tgacaggtca ttctcttgga   675420
tgttacctag ctcagattgc agcggttgaa gcttaccaaa aatatcctga tttttataac   675480
catgtattga ggaaagtgac aactttcagt gctcctaaag tgattacttc cagaactgtt   675540
tggaatgcta agaatggttt ctgggatgtt ggtttggaaa gtcgtaaatt agctgttagt   675600
ggaaaaatta agcattatgt ggttgataat gacaatgttg tgactccctt gattcataat   675660
aatcgtgata ttgttacatt tacaggtaat tcacgcttta aacaccgttc tcgtggctat   675720
tttgaaagtc caatgaatga tattcctaac tttaatattg gtaaacaagc taccttggat   675780
aaacatggtt atcgtgatcc gaaattggat aaagtgcgat tctttaagaa acaggctctg   675840
cctcgatctt ctagtcaacc aagcgctgaa ccaatggaaa atattgcctc aggaaaacag   675900
gttactcaaa gttcgacagc tttcggagga gatgctagaa gagctgtgga tggcaaagtc   675960
gatggtaact atggtcacaa ttctgtcact catacaaact tccaatctaa gccttggtgg   676020
caagtagatt tggctaaaga agaaaccatt cgccaaatca atatttacaa ccgaacagac   676080
actgcccagg atagattggc aaactttgat gtcattcttt tagacagttc tggtaaagaa   676140
attgagtgaa aacgtataac atctcctaaa gatgtgtcag cacaaattac gattaaccat   676200
aaaaaagcgc gctatgttcg gattgagcta gaaggctata atgccctcag tcttgcagaa   676260
gttgaagttt tctgctttat agctacgaat gctgaaacgg cgacacaagt ttctaagcca   676320
gttcaaccaa tcagtcagac tcctgtgaag gataaaacat tgacaattca acacagtgga   676380
gcttacattg cccgctactc cataacttgg gaagaagttc cagtagataa agatggaaac   676440
caagttgttc gtagtcattc ttgggaagga agcggtcgca accagactgc aggttttgtc   676500
ctcaacctcc caatcaaaga aaatatgaga aatctgcgag ttaagattga gaaaaagacg   676560
ggcctactat ggaatagatg gcaaacaatc tatgaaaaca gaccaatttt agctcaaccc   676620
caccgtaaaa ttacccattg gggtacgaca ttgaattcca aggtgagtga cgatgatgtc   676680
ttgtaatctg atggtagaat gacagttagt ttgtctagtt tataagaaag tactacctga   676740
gcttgaatag gactcaggta gctctctatg aaagaacaaa attaatactc aatgaaaatc   676800
aaagagcaaa ctaagaaact agccgcaggt tgctcaaagc actgctttga ggttgtagat   676860
aagactgacg aagtcagtca catatataat ccaaggcgac gttgacgtgg tttgaagaga   676920
ttttcgaaga gtataaacag aaaggtagag cgcgtgttct aatttgaaca cgagtagaaa   676980
acttttctaa aaacaaaaac gaaaggatgg gtaaactgta ttcgctgaac tgaatacggg   677040
cgactctcct ctaaatcaaa attaagaaag gaattgaccc caccctaaaa gtagtgggaa   677100
aaagatagtt gatctagcga gcatcgctca ctgcgcccaa ctcctatttt cccttcgctt   677160
tttgatgggt ttggtatctt tctcaatata aaatataaaa taaagaaagg tagagcgtgt   677220
gttttgattt gaacacgagc ggaaaactcg gaaaatagat aatctgactg aaaaatcagg   677280
atttctcgtc aggttcctaa ttttcagtcg ttttcttctc gctctttgta tcataaatta   677340
tgtctatcca tattgctgct cagcagggtg aaattgctga taaaattctt cttcctgggg   677400
atcctcttcg tgctaagttt attgcggaga atttccttga tgatgctgtt tgttttaacg   677460
aagtgcgtaa catgtttggt tacactggta cttacaaggg tcactgtgta tctgtcatgg   677520
gaactgggat gggaatgcca tctatttcga tttatgcgcg tgagttaatc gtagactacg   677580
gtgtgaagaa attgattcgt gtgggaactg caggttcttt gaatgaagag gttcatgttc   677640
gtgaattagt tttggcgcag gcggctgcaa ccaactcaaa catcgttcgt aatgactggc   677700
cacagtacga ttttccacaa attgctagct ttgatttgct tgataaagcc taccatatcg   677760
ccaaaaaact tggtatgact actcacgttg ggaacgtttt gtcatctgat gtcttttact   677820
caaattactt tgaaaagaat atcgagcttg gtaaatgggg agtcaaggct gtggaaatgg   677880
aagcagcagc tctttactat cttgctgccc aataccatgt tgatgcgcta gctatcatga   677940
ccatctctga tagcttggtc aatccagacg aagacacaac tgcagaagaa cgtcaaaata   678000
ccttcactga tatgatgaag gttggtttgg aaaccttgat tgcagaataa ttatagccaa   678060
aaaggggctc tttgtcaact gtagtgggtt gaaaaaaagc taagcttgag aaaggacaaa   678120
tttcgtcctt tcttttttga tattcagggc gataaaaatc cgttttttga agttttcaaa   678180
gttccgaaaa ccaaaggcat tgcgcttgat aagtttgatg agattattgg tcgcttccag   678240
tttggcatta gaatagtgta gttgaagggc gttgacgatt ttctctttgt tctttagaaa   678300
ggttttaaag acagtctgaa aaagaggatg aacctgcttc agattgtcct caatgagtcc   678360
gaaaaatttc tcagggtctt tgttctgaaa gtgaaaaagt aagagttgat agatctgata   678420
gtggtgtttc aagtcttctg aatagcttaa aatcttgtca agaatttctt tatttgttaa   678480
gtgcatgcga aaagtagggc gataaaaacg tttatcgctc aatttacgac tatcctgttg   678540
gatgagtttc cagtaacgct tgatagcctt gtattcatga gattttcgtt caaactgatt   678600
cataatttga acacgaaaac gactcatggc acggctgaga tgttggataa tatggaaacg   678660
atctagaacg attttagcac acggaaaaag ctgtttagcc aagtcatagt aaggactaaa   678720
catatccatc gtaatgattt tcacttgaca acgaacggct ctatcgtagc gaagaaagtg   678780
atttcggatg acagcttgtg ttctgccttc aagaacagtg ataatattaa gattatcaaa   678840
atcttgcgca atgaaactca tctttccctt agtgaaggca tactcatccc aagacataat   678900
ctttggaagc cgagaaaaat catgctcaaa gtgaaagtca ttgagcttgc gaatgacagt   678960
tgaagttgaa atggccagct gatgggcaat atcagtcata gaaatttttt caattaactt   679020
ttgagcaatt ttttggttga tgatacgagg gatttggtga tttttcttta ccaggggagt   679080
ctcagcaacc atcatttttg aagagtgata gcacttgaaa cggcgttttc taaggagaat   679140
tctagaaggc ataccagttg tttcgaggta agggatctta gacggttttt gaaagtcatg   679200
tttcttcatt agacttccac aatcagggca agatggagcc tcataatcca gcttagcgat   679260
aatttctttg tgggtatcca tattgatgat atctagaatc ttgatgtttg ggtctttaat   679320
atcgagcagt tttgtgataa aatgtaattg ttccatatga ttctttctaa tgagttgttt   679380
tgtcgctttt cattataggt catatgggac tttttttcta cacaaaaata ggctccataa   679440
tatctatagt ggatttaccc actacaaata ttatagagcc caaaaaggaa gccctttatg   679500
aattgtagga cttccttttc ttatccagaa attgatctag ctctctctga tttcgaagaa   679560
tagtgacttt atgtgaatat tcttggcaaa gtttttggta attttctttt tgagttttgc   679620
tacgcccatc ccaaagaatc catctgataa actcccactc aaagcgttca gggcaatcta   679680
ccgccatact ttctctgact tttccacggt atttaagata acgcttaaag gctctaaaga   679740
gacaggtcaa tggcgaaaaa ttgagaaaga tgatttggtc agcttcttgc attcgttctt   679800
ggtagtagca ccaagaataa ttaccatcga tgacccaagc tttatgcttg gtgagaaagt   679860
tttttatctc ggttaacatc cattcgcagt cactgtcttg ccaaccaggt tgaaattgga   679920
gtgtgtccat gtgcagtttt ggaatggagt agtagttaga taacttttct gctatagttg   679980
acttaccaga accagaatat ccgataattg cgattttcat tttctacctt ttcctatttg   680040
gagacaaaaa aacagcctct atggactgtt tcttatttaa caagtttagc tgaaagacga   680100
gctttatcgc ggcttgcttt gtttttgtga atcaaacctt tagtttctgc tttatcgata   680160
gctgagctag cagcacggaa aagttcttca gatgggtttg cttcgaaagc ttttatagca   680220
gtacgcatag ctgatttttg agctgagttc ttttcgtttt gtttaacgtt caattcagcg   680280
cgtttgatag ctgatttaat gtttgccaat gttcttacct ccatatttac taactatacc   680340
attatatatg aaaacttacg ttttgacaag ggaaaattac ttttttaagt aaatttcatc   680400
gatttcatgg ttcttgcttt tatgaagaat cacttctgca cgatttctgg ttggttcaat   680460
ataattttgc agatttgtga gattgatact gatccagacc tgatgggcaa aggactccac   680520
ttccccaatc ggcatctgag taaaacgata atagtagcta tcagggtcgt tttgggctag   680580
actcagcatt ttcaagaaac ggtccagata ccaactttca atatcatcca ctccagcatc   680640
tacatagatg gaaaagtcaa agaagtcagt gatatagaga cgatcgtttt gtggattttg   680700
aaagacattg attccctcaa caattacaaa atcagcagct ttgacacttt gtttctcttc   680760
gggtacgatg tcgtaaactt catgagaata gacaggaata tctacatctt gtccattttt   680820
gatgcggtcc aagaagttga gaagagcttc catatcatag ctttcaggaa atcctttacg   680880
atttaaaatc ccctgctcaa tcaaggtttg attgggatag agaaaaccat cagttgtaac   680940
caactcaacc gtagcatctg taaacgtacg ggacagtagg atttgaagta ggcgactggt   681000
tgtggatttt ccaacggcaa cactcccaga aaccccaata ataaaaggtt gagatttact   681060
ttcacgttgg aggaaaattc cttttgaaaa ggctaaatct tccttagttc gcttgtaaat   681120
ctgaatcaaa tgagccaagg ggagatagat atctgtaacg tcttggagac tgatttggtc   681180
attaaaactc ttgatagatt ccaattcttc ttctgtcaaa ggaggtgttg tctttcgatg   681240
taaagattgc caagtctggc ggctgatttt ttcaaaatgt aaaaattcgt tggtcatttg   681300
ttttccccta gatattttgt ctatcatacc ataaaaagct aaaaaaataa agcggtttct   681360
tgaatgtggt aagtcaatgg tatatagtat aagtgatcaa tttattgatg aaataggaga   681420
tagattctac tgatttataa gcttataaag ggggcttttt agttcacaac ttataggagg   681480
tgtactatga aaatcttaaa acgttacata ttggaactct gttttatttt aagttttgct   681540
ttacctttta taaaaggaac caatgcagat aatggtagat gctttgtgga aacctattac   681600
ggttttactt ttttgatgga acatgctatt gtaacagctg tctttatttg ttcgttctta   681660
attgctttct tactaaaaaa cgatggacga aatggattgc tgcgggtagt tattgctttt   681720
tagtcctacg gattgcgaca gagggttatt tcttccacat gtcactagaa gatttgatac   681780
gactttggac aagtttggaa atcctgacat aaacgtatca gttgggcttt tatctaaaca   681840
ttttgttagg aattttgttg ataataaagt attttaaggt taagcaatag aaataataat   681900
ctgcctgatt atagatgata aactttttgt ttttatctgg actgtgatat ttatagttct   681960
aaatggttta ttatttataa gtgttgaaag agattgaaga aaatggcttc gtgacttgct   682020
ttcttcggtc tttttcgttt tattatcaat ttgtaaacga tttacaattt gagtcaaatt   682080
atggtaaaat agtgtcatga gtaaaatgta ctatgcagaa aatcctgacg ctgctcacga   682140
cattcatgag ttgagagtgg acttgttggg agaaaaaatg acttttttga cagatgcggg   682200
tgtttttagc aagaaaatgg ttgactttgg aagtcaactc ttgctcaagt gtctggatgt   682260
caaccaagga gagacagtcc tagatgtagg ctgtggttat ggtccattag gtttgtcctt   682320
ggtcaaggtt tacggagttc aggcgaccat ggttgatatt aacactcgtg ccctggattt   682380
agctcagaga aatgctgaaa aaaataatgc aaaagcgacg atatttcaat ctaatattta   682440
tgcaagagtt caagggcgat ttgaccatgt catttccaat cctcctatcc gtgcgggcaa   682500
gcaagtcgtt catgaaatca tcgagaaaag taaagatttc ttggaaattg gtggagattt   682560
gaccatcgtc atccagaaaa aacaaggagc tccaagtgcc aagtctaaga tggaagatgt   682620
gtttggcaat tgtgaaatcc ttaaaaaaga caagggatac tatatcctta gaagtgtgaa   682680
agaatgagag cagttgattt aatccaaaaa aaacgagacg gtcaagaact gacttcaagt   682740
gaaattgaat ggctgataga aggctatgta tcaggaactg ttcctgatta tcagatgtct   682800
gcctttgcta tggctgttta ttttaaagga atgacgactc gagaaatctc tgatttaacg   682860
atgaatatgg ttaagactgg gcaagagttt gacctgtcag ccattgatgg tgtgaaagtt   682920
gacaagcatt ctactggtgg tgtcggcgat aaggtaacct tgattttagc tcctcttgtt   682980
gctagcttcg gtgtgcctgt agcaaaaatg agtggtcgtg gtcttggcca tacaggcgga   683040
acaattgata aattggagtc cattaagggc tatcaagtag aacgtagtca agaggatttt   683100
attcgtcagg ttcaggatat tggagtatct gtcattgggc aatcagacca gctggtcaaa   683160
gcagataagc ttctctatgc ccttcgtgat gtgaccgcaa ctgtcgacac gattcctttg   683220
attgcgagtt cggtgatgag caagaaaatt gcggcagggg cggatgctat tttgctagac   683280
gtgactgtcg gtgagggtgc cttcatgaag acggttgatg aggcgcgtga gttggctcaa   683340
actatggtag atcttggtaa ggttgttgga cggaagacag tagcagtgat tacggatatg   683400
agccagcctt tgggacgagc gattggaaat cgtctggaaa tccttgaagc attggagatt   683460
ttgcaaggtc aaggacgtca ggatattacc cactttattt gtgaattggc tcaaattatg   683520
cttggtttgg caaatgttaa caaaactgtt gaagaagttc accaacatct tgagaatggt   683580
caagcactgg ctaagtttga ggaaatggtg caagcccaag gtggagactt ggaagacctc   683640
tatcgtcctg taaatgtagc tcatgtggtg gaaatccctg ctcaggaaac gggtgtcatt   683700
tcagctcttc cagctatgga ctttggtctt tatgccatga ggctgggtgc tggtcgtgca   683760
gttaagtctg atgccttgga ctatgaaaca ggaattgttt ttgaaaagaa gattggagac   683820
tccgttcaaa agggtgaaat tgttgcaaaa gtatacacaa atgaaaaaat tccacctcaa   683880
ctagttacag atttccaaaa atgtgttaaa ataagtgatg aagtgaaaaa aatccgtgaa   683940
attgtagaaa tcatctccta aatggaggga aaaccgaaat gaaattaaat aaatatatag   684000
atcatacgct tttaaaacaa gatgcaaaga aaaaacaaat tgatagtttg ttgtctgagg   684060
ctagagagta tgactttgcc agtgtttgcg ttaatccgac ctgggttgaa catgctaaaa   684120
aaggacttga aggcacagat gttaaggttt gcacagtagt aggtttccct ttgggagcaa   684180
caacttcagc cgtgaaagca tttgagacaa aagaagctat ccaaaatggt gcagatgaga   684240
ttgatatggt gatcaatgtt ggagctctca aatcaggtaa tttagccttg gttgagtcag   684300
atattcgcgc agtagtggaa gcaagtggtg ataagttagt gaaagtcatt attgaagctt   684360
gccttctgac agaccaagaa aaagttgttg tttgccaatt ggcccaaaaa gctggggctg   684420
actttgtcaa aacatctact ggcttttcaa ctggtggtgc tacgatagca gatgttacat   684480
taatgcgtga aacagttgga tctgatatgg gtgtcaaggc cgccggtgga gctcgttctt   684540
atgcagatgc tcttgccttt gtcgaagcag gtgcgacccg tatcggaacg tcagctgggg   684600
tagctatttt aaaaggagaa ttggcagatg gcgactactg agttgattga actggcaatt   684660
gaaaccagca aacatgccta tgtcccctat tctcactttc ctatcggagc agttttagta   684720
gctaaagacg gaagtgttta cacgggagtg aatattgaaa atgctagcta tcctttgacc   684780
aattgcggtg agagaacagc tatttttaag gctatatctg aaggccaaag agaattttca   684840
gaattgattg tctatggtca aactgaaaaa ccgatctcgc catgtggtgc ttgtcgccaa   684900
gtgatggctg aattttttga acaagatcta aaagtgacct tagtcgcaaa agataaatcg   684960
acggtcgaga tgacggtcgg ggaattactt ccatactctt ttacagactt aaactagtct   685020
gagtcgctct ctgagtggca cggtccttgt ggccaaccaa tccatacttg caacatcgtt   685080
gcacatctta tttaggaggt tcagtaatga acaagaaaca atggctaggt cttggcctag   685140
ttgcagtggc agcagttgga cttgctgcat gtggtaaccg ctcttctcgt aacgcagctt   685200
catcttctga tgtgaagaca aaagcagcaa tcgtcactga tactggtggt gttgatgaca   685260
aatcattcaa ccaatcagct tgggaaggtt tgcaggcttg gggtaaagaa cacaatcttt   685320
caaaagataa cggtttcact tacttccaat caacaagtga agctgactac gctaacaact   685380
tgcaacaagc ggctggaagt tacaacctaa tcttcggtgt tggttttgcc cttaataatg   685440
cagttaaaga tgcagcaaaa gaacacactg acttgaacta tgtcttgatt gatgatgtga   685500
ttaaagacca aaagaatgtt gcgagcgtaa ctttcgctga taatgagtca ggttaccttg   685560
caggtgtggc tgcagcaaaa acaactaaga caaaacaagt tggttttgta ggtggtatcg   685620
aatctgaagt tatctctcgt tttgaagcag gattcaaggc tggtgttgcg tcagtagacc   685680
catctatcaa agtccaagtt gactacgctg gttcatttgg tgatgcggct aaaggtaaaa   685740
caattgcagc cgcacaatac gcagccggtg cagatattgt ttaccaagta gctggtggta   685800
caggtgcagg tgtctttgca gaggcaaaat ctctcaacga aagccgtcct gaaaatgaaa   685860
aagtttgggt tatcggtgtt gatcgtgacc aagaagcaga aggtaaatac acttctaaag   685920
atggcaaaga atcaaacttt gttcttgtat ctactttgaa acaagttggt acaactgtaa   685980
aagatatttc taacaaggca gaaagaggag aattccctgg cggtcaagtg atcgtttact   686040
cattgaagga taaaggggtt gacttggcag taacaaacct ttcagaagaa ggtaaaaaag   686100
ctgtcgaaga tgcaaaagct aaaatccttg atggaagcgt aaaagttcct gaaaaataat   686160
ggatggaagt catttcttag gaagcggcca agggccgctt ttttaagagt tgagacaaag   686220
tcattttgtc taagtaaagc ttgctactag acaaactagc aagttttatt gaaataaaat   686280
aagactctga aaggaagagc acatggcaca cgaaaatgtc attgagatgc gtgatattac   686340
caaggtgttt ggtggatttg ttgccaacga caaaatcaac ttgcacctac gaaaaggtga   686400
aattcatgca cttttaggag aaaatggggc tggtaagtcc acgctaatga acatgttagc   686460
aggccttctt gaaccaacta gtggtgaaat cgcggtcaac ggtcaagttg tcaatctcga   686520
ctccccatct aaagcagcta gcttgggaat cgggatggtt caccagcact ttatgttggt   686580
tgaagccttc acagtggctg aaaacatcat tttaggtagt gaattgacta aaaatggtgt   686640
gctagatatc gctggagcta gcaaagaaat caaggctctt tctgaacgtt atggcttagc   686700
tgttgaccct tctgccaagg tagcagatat ctcagttgga gcccaacaac gtgtagaaat   686760
tttaaaaaca ctttatcggg gggctgatat ccttatcttt gacgaaccaa cggctgtttt   686820
gactccatca gaaattgatg agttgatggc tattatgaaa aatcttgtca aagaaggaaa   686880
atcaattatc ttgattaccc acaaattgga tgaaattcga gcagtttctg accgtgttac   686940
agttatccgt cgtgggaaat caattgaaac cgttgaaatt gcaggggcta ccaatgctga   687000
tttggcggaa atgatggtag gacgttctgt ttcctttaaa acagagaagc aagcctctaa   687060
accaaaagaa gtggttttgt ctatcaaaga tttggtggtc aatgaaaacc gtggtgttcc   687120
agctgttaaa aatctgtcct tggatgttcg tgctggagag attgttggta ttgcggggat   687180
tgatggaaat ggtcagtctg aactgattca agccattaca ggtcttcgta aggttgaatc   687240
tggtagcatt gagctaaaag gagattcaat tgtaggcttg cacccacgtc agattacaga   687300
actaagtgtt gggcacgttc cagaagaccg tcaccgtgat ggcttgattt tggaaatgat   687360
gatatctgaa aatattgccc ttcaaaccta ctataaagaa ccacatagta aaaatggaat   687420
tttgaattat tcaaatatta cttcttatgc taaaaagctg atggaagagt ttgatgttcg   687480
cgctgccagt gaattagttc ctgcagctgc actctcagga ggaaatcaac aaaaagcaat   687540
tattgctcgt gaaattgatc gagatcctga tctccttatc gttagccagc caactcgtgg   687600
gttggatgtc ggtgccattg agtatatcca caaacgcttg attgaagagc gtgataatgg   687660
caaggctgtc cttgttgtca gctttgaatt ggatgagatt ttaaacgtct cagaccgtat   687720
tgccgttatc cacgatggta agattcaagg tattgtatca ccagaaacaa ccaataaaca   687780
agaacttggt gtcttgatgg ctggtggaaa cttgggaaag gagaagagtg atgtctaaaa   687840
aattacaaca aatttcggtt cccttgattt ctgtattcct aggaatttta ctcggagcca   687900
ttgtcatgtg gatcttcggt tatgatgcta tttggggcta cgaagaattg ttctatacag   687960
cctttggcag tctgcgtggg attggagaaa tcttccgtgc tatgggtcct ctggtcttga   688020
ttggtcttgg ttttgccgtt gccagtcgag ctggtttctt taacgtcgga cttcctggtc   688080
aggctttggc aggttggatt ctcagtggtt ggtttgccct gtcgcatcca gatatgcccc   688140
gtcccttgat gattctagca accatcgtga ttgccttgat tgctggtggg attgtcggag   688200
cgattccagg tattcttagg gcctatctag ggacgtcaga ggttattgta accatcatga   688260
tgaactacat tgtcttgtat gtagggaatg cctttatcca tgctttccct aaagacttca   688320
tgcaaagtac agattcgacc attcgtgttg gggctaatgc aacctatcag acaccttggt   688380
tggctgagtt gactggtaac tcacggatga atattggtat tttctttgcc atcattgccg   688440
ttgcagttat ttggttcatg ctcaagaaaa caactcttgg ttttgaaatc cgtgcagttg   688500
gtcttaatcc acatgcttca gaatatgctg gtatttctgc caagcggact attatcctat   688560
ctatgattat ttcaggtgcc ttggcaggtc ttggtggagc tgttgaaggt ttgggaacct   688620
tccagaacgt ctatgttcaa ggttcgtcat tagctatcgg atttaacgga atggcggtta   688680
gtttgcttgc ggccaactca ccaattggta tactctttgc agccttccta tttggcgttc   688740
tccaagttgg ggctcctggt atgaatgcgg cgcaggtacc atctgagctt gtcagcattg   688800
taacagcgtc tattatcttc tttgtcagtg ttcattacct tatcgaacgc tttgtcaaac   688860
cgaaaaaaca agttaaagga ggtaagtaaa gatgtctatt ataaccttgc tccccctctt   688920
ggtgtcttct atgctgattt actcagcacc tctcatcttt acaagtatcg gtggtgtttt   688980
ctctgaacgt ggtggtgtgg taaacgttgg ccttgaagga attatggtta tgggtgcctt   689040
ttctggagtt gtctttaacc ttgaatttgc agaacaattt ggagcagcaa ctccatggct   689100
atccttgctt gtagcaggat tggttggtag tgttttctct atcatccacg cagcagcgac   689160
ggttcatttc cgtgcagacc atgttgtcag cggtacggta ttgaacttga tggcgcctgc   689220
cttggctgtt ttcttagtta aagttcttta taacaaagga caaaccgaca acctaagtca   689280
aacttttgga cgctttgatt tcccagtctt ggcaaatatc ccagtgattg gtgatatctt   689340
cttcaagtca actagtctac ttggttatct ggcgattgcc ttctcattcc ttgcttggtt   689400
tattctcttt aagactcaat ttggtcttcg tctccgctct gtcggtgaac atcctcaagc   689460
agcggatacc ttgggaatca acgtctacaa gatgagatat ttaggggtta ttatttcagg   689520
ttttctaggt ggaattggcg gagcgattta tgcgcaatca atctcagtta acttctcagt   689580
gacaactatt gttggacctg gatttatcgc ccttgctgcg atgatctttg ggaaatggaa   689640
tccaatcggt gctatgcttt ctagtctctt ctttggactt tcacaaagtt tggctgttat   689700
cggttctcaa ttgccgttcc tacaaggagt gccagcggtt tatcttcaaa ttgcacctta   689760
tgttttgaca attcttgtct tagcagcctt ctttggaaaa gcagtcgcac caaaagcaga   689820
tggtatcaac tacatcaaat caaaataagc atacaaaaaa acgtcagtcc aatgactgaa   689880
ctacacccca aaagttagac agaaaaaatc taacttttgg ggtgttttta ttatgaaatt   689940
aagttatgat gataaagttc agatctatga acttagaaaa caaggatata gcttagagaa   690000
gctttcaaat aaatttggga taaacaattc taatcttagg tatatgatta aattgattga   690060
tcgttacgga atagagttcg tcaaaaaagg aaaaaatcgt tactattctc ctgatttaaa   690120
acaagaaatg attaataaag tctgacatga aggctggact aaagatagag tttctcttga   690180
atacggtctc ccaagtcgta cgatacttct taactggcta gcacaataca ggaaaaacgg   690240
gtatactatt gttgagaaac caagagggag agtacctgag agcggagaat gccatcctaa   690300
aaaagttaag agaactccga ttgaaggagg aaaaagagaa agaagaaaga cagaaattgt   690360
ttaagaatta atgactgagt tttcgttaga tcttctttta aaagtcatta aactagctcg   690420
ttcgacctac tactatcact tgaaacagct agataaacca gataaggacc aagagcttaa   690480
agctgaaatt caatccattt ttatcgaaca caaaggaaat tatgcttatc gtcggattta   690540
tttagaacta agaaatcgtg gttatctggt aaatcataaa agagttcaag gcttgatgaa   690600
agtactcaat ttacaagcta aaacgcgaca gaaacgaaaa tattcttctc ataaaggaga   690660
cgttggcaag aaggcagaga atctcattca aggccaattt gaaggctcta aaacaatgga   690720
acagtgctac acagatgtga cagaatttgc cattccagta agtacttaaa agctttactt   690780
atcaccagtt ttagatggct ttaatagcga aattatcgcc tataatcttt caacttcacc   690840
caacttagaa caagtacaaa caatgttgga acaggcattc acagagaagc actacgagaa   690900
tacgattctc catagtgacc aaggctggca ataccaacac gattcttatc atcggttcct   690960
agagagtaag ggaattcaag catccatgtc acgtaagggc aacagccaag acaacggtag   691020
gatggaatct ttctttggca ttttaaaatc cgaaatgttt tatggctatg agaaaacatt   691080
taaatcactt aatcaattgg aacaagccat tatagactat attgattact acaacaacaa   691140
acgaattaag gtaaaactaa aaggacttag tcctgtgcag tacagaacta aatcctttgg   691200
ataaattatt tgtctaactg tttgggggca gtacagaact ggcattttat tttttaggat   691260
cttgatgggt taggttcaat ccccaaggga ccaaattttc agttttattt ttgatacgag   691320
ctatattgtc cttatgacga atgataatca aactagcaag tgctaagata atagcgatga   691380
agagagagtc atagttactc aggataaaac caaaaagtgg aaagagcaga accccgataa   691440
cagccgcaat cgatgctgtg acactagaca gtgaaatcat actgccaaga tagagagctc   691500
caaagaagat aatcgcaagg tagagacaga agataggcgc aaatccgaaa atcactccag   691560
cactggttgc gacagcctta ccacctttaa atcctgcaaa gatagggaag gtatggccga   691620
taacagccaa aagtccaaag atgagaggag aaacgccttg tagatgaaaa ataatcggaa   691680
gcagcgttgc tagggttcct ttgaaaaagt caatcacaaa ggttgccata ccagctttct   691740
tacctaaaat gcggaaggtg ttggtcgttc cagtgttacc agaaccatgc tcgcgtagat   691800
tgatttgaaa gaatacttgt ccaatccaga gaccagatgg aatcgaaccc agcagatagg   691860
ctaggattaa taaaactatt gtaatcatac tcctattata tcatgaattg ggaaagaaaa   691920
gcagagaatc tctgctgaaa ttgtcacatc ggagaaagaa aaattttgca aaatccttgg   691980
aaaacctgta gaatagtaaa gatgaacgaa taggaggttc cttgtgtcaa aaaaggaaat   692040
caatattaac aattataatg atgatgctat tcaggtgcta gaagggttgg atgcggtccg   692100
aaaacgtcca gggatgtata ttggatcgac cgatggcgct ggtcttcatc acctagtttg   692160
ggaaatcgtt gataatgcag tcgatgaagc cttgtctggg tttggtgatc gtattgatgt   692220
aactatcaat aaagacggta gtctaacggt tcaagaccat ggacgtggga tgccgacagg   692280
tatgcacgct atgggaattc caactgttga ggttatcttt accattcttc atgccggagg   692340
gaaattcggt caaggtggct ataagacatc aggtggactt cacggagtgg gttcttccgt   692400
tgttaacgcc ctttctagct ggttagaagt tgaaattacc cgtgatggcg cagtttacaa   692460
gcaacgtttc gaaaatggtg gaaaacctgt cacgactttg aagaaaatcg gtacagcacc   692520
caagtctaaa acaggcacca aagttacttt tatgcctgac gcgactatat tttctacgac   692580
agatttcaag tacaatacca tttcagagcg ccttaatgaa tcagcctttc tcttgaaaaa   692640
tgtgaccttg tctttaacgg acaagcgaac aaatgaagcg attgagttcc actatgagaa   692700
tggagtacaa gattttgttt cttatctcaa cgaagataag gaaatcttga cgccagttct   692760
ttactttgaa ggggaagaca atggttttca agtggaagta gccctccagt acaatgacgg   692820
attctcagat aacattctat cttttgtcaa taacgttcgc accaaggacg gtggaacgca   692880
cgagacagga ctcaagtctg ccattaccaa ggtcatgaat gactatgcac gtaaaacagg   692940
tcttctcaag gaaaaagata aaaaccttga aggttcagac tatcgtgagg gactagcggc   693000
cgttctttct atcttagttc ctgaagaaca cttgcagttt gaaggacaga ccaaggataa   693060
actaggaagc cccctagctc gcccagttgt ggatggaata gtggctgata agttgacctt   693120
tttccttatg gaaaatgggg aattagcttc taacctcatc cgcaaggcta tcaaggcccg   693180
tgatgctcgt gaagcagcac gtaaggcgcg tgatgagagc cgaaatggga agaaaaacaa   693240
gaaagataag ggcttgttgt ctgggaaatt gaccccagcc caatctaaga atcctgctaa   693300
gaatgaactc tatctagttg agggggactc tgccggtggt tctgccaaac aaggtcgtga   693360
ccgcaagttc caggctattc tacctcttcg tggtaaggtt gtcaatacag ccaaggccaa   693420
gatggcggat atcctcaaaa atgaagagat caataccatg atttatacca ttggtgcggg   693480
tgttggagca gacttctcta ttgaagatgc caactatgat aagatcatta tcatgaccga   693540
tgcggatacc gacggtgccc atatccagac cttgctcttg acatttttct accgttacat   693600
gcgtccgcta gtcgaggcag gtcatgtcta tattgccctc ccacctcttt acaagatgtc   693660
caaaggtaaa ggcaagaaag aagaagtggc ctacgcttgg acggacggag aactagaaga   693720
actccgtaaa cagttcggta aaggcgctac cctccaacga tacaaaggac ttggtgagat   693780
gaatgcggac cagctctggg aaacaaccat gaacccagaa acacgtaccc tcatccgtgt   693840
cacaattgaa gatttagcgc gcgccgaacg ccgcgtcaat gttctcatgg gagataaggt   693900
agaaccacgc cgtaaatgga ttgaagataa tgtcaagttt acgctagaag aaacgacagt   693960
gttttaatga aagaaaataa tatgttagta aactggaaat tagagtcgga tgtgaatgac   694020
tatgtgaaaa agcagtttga aaatcttggt ttgaaaaaat tgcaggatta ttaatgaaga   694080
atctgctatg agtgcttatc tcaaagaggc gcttaaggga gcggctaaga cacaaactaa   694140
gactaatttt ggaaaaccag attttcatat tgaaaaatac aaacaggata gtttggttac   694200
ttatcgtaac tgaacacggg aggaattccc gtaaaatatc ttttactgca taaaaaccta   694260
ctctacattc tttgaaagga gttgaacacg ccctagatac tgtgtgaaaa agataaattc   694320
tcttgtgagt ttgcttactt caagaatttt ctattttcac ttggtatttt atgggctttg   694380
tatcttatgt ctaacattca aaacatgtcc ctggaggaca tcatgggaga gcgctttggt   694440
cgctactcca agtacattat tcaagaccgg gctttgccag atattcgtga tgggttgaag   694500
ccggttcagc gccgtattct ttattctatg aataaggata gcaatacttt tgacaagagc   694560
taccgtaagt cggccaagtc agtcgggaac atcatgggga atttccaccc acacggggat   694620
tcttctatct atgatgccat ggttcgtatg tcacagaact ggaaaaatcg tgagattcta   694680
gttgaaatgc acggtaataa cggttctatg gacggagatc ctcctgcggc tatgcgttat   694740
actgaggcac gtttgtctga aattgcaggc taccttcttc aggatatcga gaaaaagaca   694800
gttccttttg catggaactt tgacgatacg gagaaagaac caacggtctt gccagcagcc   694860
tttccaaacc tcttggtcaa tggttcgact gggatttcgg ctggttatgc cacagacatt   694920
cctccccata atttagctga ggtcatagat gctgcagttt acatgattga ccacccaact   694980
gcaaagattg ataaactcat ggaattcttg cctggaccag acttccctac aggggctatt   695040
attcagggtc gtgatgaaat caagaaagct tatgagactg ggaaagggcg cgtggttgtt   695100
cgttccaaga ctgaaattga aaagctaaaa ggtggtaagg aacaaatcgt tattattgag   695160
attccttatg aaatcaataa ggccaatcta gtcaagaaaa tcgatgatgt tcgtgttaat   695220
aacaaggtag ctgggattgc tgaggttcgt gatgagtctg accgtgatgg tcttcgtatc   695280
gctatcgaac ttaagaaaga cgctaatact gagcttgttc tcaactactt atttaagtac   695340
accgacctac aaatcaacta caactttaat atggtggcga ttgacaattt cacacctcgt   695400
caggttggga ttgttccaat cctgtctagc tatatcgctc accgtcgaga agtgattttg   695460
gcgcgttcac gctttgacaa agaaaaggct gagaaacgtc tccatatcgt cgaaggtttg   695520
attcgtgtga tttcgatttt ggatgaagtc attgctctta tccgtgcttc tgagaataag   695580
gcggacgcca aggaaaacct caaagttagc tatgatttta cggaagaaca ggctgaggct   695640
atcgtaactt tgcaactgta ccgtttgacc aataccgatg tggttgtctt gcaggaagaa   695700
gaagcagagc ttcgtgagaa gattgctatg ctggcggcta ttatcggtga tgaaaggact   695760
atgtacaatc tcatgaagaa agaacttcgt gaggtcaaga agaaatttgc aactcctcgt   695820
ttgagttctt tagaagacac tgcgaaagca attgagattg atacagctag tcttatcgct   695880
gaggaagata cctacgtcag cgtgaccaag gcaggttaca tcaagcgtac cagtccacgt   695940
tcctttgcgg cttccacctt ggaagaaatt ggcaagcgtg atgatgaccg tttgattttt   696000
gttcaatctg ccaagacaac ccagcacctc ttgatgttca caagtcttgg aaatgtcatc   696060
tacagaccaa tccatgagtt ggcagatatt cgttggaagg acatcggaga gcatctgagc   696120
caaaccatca caaactttga aacgaatgaa gaaatccttt atgtggaagt actggatcag   696180
tttgacgatg cgacaaccta ctttgcagtg actcgccttg gtcaaatcaa acgggtagag   696240
cgaaaagaat tcactccatg gcggacctat agatctaagt ctgtcaagta tgctaagctc   696300
aaagacgata cagatcagat tgtagcagtg gctccgatta aactagatga tgttgtcttg   696360
gttagtcaaa atggttatgc cctgcgtttc aatatcgaag aggttccggt tgtcggtgct   696420
aaggcagcag gtgtcaaggc tatgaatttg aaagaagatg atgtcctcca atctggcttt   696480
atctgtaata cttcgtcctt ctacctcttg acccagcgtg gaagcttgaa acgtgtttcc   696540
attgaggaaa ttctagcaac cagccgtgcc aaacgaggat tacaagtctt gcgtgagttg   696600
aaaaacaaac cgcatcgtgt cttcttggca ggagcagttg cagagcaagg atttgttggc   696660
gatttcttca gtacggaagt ggatgtgaac gaccaaactc tgcttgtcca atccaataaa   696720
ggaacaatct atgaaagccg attgcaagac ttgaacttgt cagaacgcac tagcaatgga   696780
agcttcattt ctgacacgat ttcagatgaa gaagtttttg acgcttatct tcaggaagta   696840
gttactgaag ataaataagt gaaatgaaga atcagttcta agagttggtt tttattggag   696900
aaattttctg aaaattacaa aatatacttg ctattttaga aaaatagtgt agaatataag   696960
aaataggttt ttagaataag gagtggaata tgacagtaac gattgattgg gaaaacctcg   697020
gtttttccta tatgaaatta ccttatcgct atcttgctca tttcaaaaat ggacaatggg   697080
atcaaggaga gcttacagag gatgcaactt tgcatatttc agagtcttct ccaagtcttc   697140
actatggaca acaagcattt gaaggtttga aagcttatcg tactaaggat ggcagtgttc   697200
aactgttccg tcctgatgaa aatgctaaac gtctgcaacg tacatgtgac cgtctcttga   697260
tgccacaagt tccgacagac atgtttgtag aagcttgtaa agcagttgtc cgtgcgaatg   697320
aagaatacgt accaccatac ggaacaggtg gaaccttata tcttcgccct cttttgattg   697380
gtgtcggaga tattatcggg gtaaaaccgg cagaagagta cattttcacc atctttgcta   697440
tgccagttgg aaattacttt aaaggtggtt tggtcccaac caacttcttg attcaggatg   697500
agtacgaccg tgcagcacca aatggtacag gtgcggctaa ggttggtgga aactatgctg   697560
caagtctctt accaggaaaa atggccaagt cacgtcattt ctcagatgtt atctatctgg   697620
acccatcaac tcatacaaag attgaagaag tcggatcagc taacttcttt ggaattacag   697680
ctgataatga atttgtaaca ccattgagtc catctatctt gccatctatt accaagtatt   697740
ccttgcttta tttggcagaa catcgcttgg gattaactcc tattgagggt gatgttccaa   697800
ttgataatct tgaccgtttt gtagaggcag gtgcctgtgg tacagcagcg gttatttctc   697860
caattggagg tattcaacat ggtgatgatt tccatgtatt ctatagtgaa acagaagtag   697920
gtcctgtgac gcgtaaatta tataatgaat tgacgggtat tcagtttggc gatattgaag   697980
cgccagaagg ttggattgta aaagtagatt aaaataaacc aaaggagatt ctttatgaaa   698040
tagaaaaagt ggctcttaac agcaggagtg gtcctgagca cgtcagctat tttagtggct   698100
tgtggaaaaa ctgataaaga agcagatgca ccgacaacat tttcttatgt ctatgcagta   698160
gatccagcat cattgggcta cagtatagcg actcgaacat cgaggacaga cgttattgga   698220
aatgttattg atggtttgat ggaaaatgat aaatacggca atgttgctcc ttctcaaaaa   698280
gactatgatt tgaacagtac aggatgggct ccaagctatc aagatccagc gtctcacttg   698340
aatattatag atccaaaatc tggttctgcc atgaaacacc ttggtattac gaaaggaaaa   698400
gataaggatg ttgtagctaa acctggtttg gataaatata agaaattgtt agaagatgct   698460
gtttctgaga ccactgacct agagaaaaga tatgaaaaat atgccaaagc tcaagcttgg   698520
tcgacagata gttcattatt gatgccaaca gcttcatctg gtggttctcc agttgtaagt   698580
aacgtagtac cattctcaaa accatactca caagttggta ttaaggggga tccatatatc   698640
tttaaaggaa tgaaattgca aaaagatatt gttacaacaa aagaatataa cgaggttttt   698700
aaaaaatggc aaaaagaaaa attggaatcc aatagcaaat accaaaaaga actagaaaaa   698760
cacattaaat aaggaatggt attgatcttg ataaaatttt aaaaatactg tcattttgaa   698820
tataaaggag tttgatatgg agtggattag attaatagga atagcaatca ttgttgtggg   698880
ttttatttta aaatttgata caattgcaac agtagtctta gctggtttgg ttacagcttt   698940
agtttcaggt gtttctctcg ttgaattttt ggagattttg ggaaaagaat ttagcaatca   699000
gcgagtgctc acgattttta tggttacctt gcctcttgtg gggctgtcag aaacctttgg   699060
actcaagcaa cgatcaatcg atttgattcg aaagattaaa ggtctgacag ttggaaactt   699120
ctatacagtt tatttcttta ttcgagagtt agctggtttc ttttcaattc gtctaggagg   699180
acaccctcag tttgtcagac ctttggttca acctatggga gaagcagctg cagagtctca   699240
attaggtaga aagttaacag aggttgaaga tgagacaata aaagcgcgtg cggctgcgaa   699300
tgaaaatttt ggaaatttct ttgctcaaaa tacgtttgta ggtgctgggg gagtcctctt   699360
gataggggga acattagatc agttaggcta tgaaagcaat tatgcaggga ttgcttctac   699420
atctattatt gttgctgtta taacacttat tgtagtgggg atttataatt atttatttga   699480
taaaaaattg atatcaaaaa agactagggg aggagaacaa aaatgacaga gttggcaaag   699540
caactattag agttgaccta tattgtgatt ggttgtcaat ttctccatac agcctattgt   699600
agttataaag ataaaacaaa cccagttcga cttgggacat ctgcattttg gactctattg   699660
tctattacgt ttataggtgg ttcctatatg ccaaatatga gtattggtat tattgtaatc   699720
ctattatcgc tgttaacatt gtttaagcaa gtccgtatcg gaaccttgcc atccttagat   699780
gaaatgaaag ccaatattga atctaacagg ttgaaaaata aaatttttat tccagttatg   699840
ctgatggcaa tacttgcgtt ggtcttagcg caaatgattc cagaatttag caagatttcg   699900
attagccttg ccgccttgtt tgctacaatt tctgttcttg tgattaccaa tagtcaccct   699960
aagagtctgt tatcagaaaa taatcgaatg actcagcaag tttcaacaag tgggattgtt   700020
cctcaattat taggggcttt gggggctatt tttactgtag caggtgttgg tgatgttatc   700080
tctcatctga ttagcggtat tgttccttca gatagtcgct ttataggagt tttggcctat   700140
gttcttggaa tggttctatt cacaatgatt atgggaaatg cttttgcagc attcaccgtt   700200
attacagcag gtgttggagt tccctttgta tttgctctgg gagctaatcc aattgtggct   700260
ggtgctcttg ccatgacagc aggttattgt gggaccttat tgaccccaat ggctgctaat   700320
tttaacgctc taccagcagc attgatggat atgaaagatc agaatggcgt tataaaggct   700380
caagcaggtg ttgctctagt aatgattgtt attcacatat tcttaatgta ctttctcgca   700440
ttttagtaaa ggaaaataaa atgaaaatat tggttacagg ttttaatcct tttggaggtg   700500
aaaagattaa tccagctttg gaggctgtaa aattattacc atctgagatt aatggggctg   700560
aagttcgctg ggtagaaatt ccaacggttt tttataagtc gtcagaagtt ttagaggcag   700620
aaatattacg atatcaacca gatgctgtac tttgtattgg acaagcaggc ggcaggaccg   700680
gcttaacacc tgaacgagtg gctattaatc aagatgatgc tcgcatacct gataacgaag   700740
gcaatcaacc aattgataca ccgattcgta ttgatggagc atcggcctat tttagtagtt   700800
tacctatcaa agcgatggta caagctatca aaaaacaggg acttccggca gttgtatcca   700860
atagtgcagg aacctttgtt tgcaatcatt tgatgtacca agctctttat ttagtggata   700920
aaaaattccc taatatgaga gcaggtttca tgcatattcc atatatgatg gaacaagtag   700980
taaataagcc gaatactgca ggaatgagtc tatgtgatat tgtaagaggc atagaggtag   701040
ctattgaagc tattgtagac tacaaagata aggatttgca gttagtaggc ggtgagactc   701100
actgataacc taaaaaggat agtcaattat gcttgtttac taactattaa ctatgctaaa   701160
tcaattgagg ttgtttacat aaaactctat atcagagaag cctgatatag agttttttct   701220
tgctagtttt aggatttttt tgtaaaatag aaaaagtgaa gagaggtatg aaatgagcaa   701280
gaaagataaa aaaatcgaaa ttcaagtagc ggatgccaaa gttaatgttg gtaaagacag   701340
ttttgaaggt tatacattga ctatcggtaa aaaagttatc ggagaaattg ccgaattaga   701400
cggacaattt gccattataa agaatgggaa tgtcgatagt ttttataaaa aattggaaaa   701460
agctgtggaa attttgattg aaaattataa tttagcaaaa taagtcttgt ttttttgaaa   701520
ttttcatgat ataatagtcc atgttgattg taggagagat agcgaagagg ctaaacgcgg   701580
cggactgtaa atccgctcct tcgggttcgg gggttcgaat ccctctctct ccatttcatt   701640
aatggggtat agccaagcgg taaggcaagg gactttgact ccctcatgcg ttggttcgaa   701700
tccagctacc ccagttctta ggtaataatc aagatagaaa gcaaaatatc ttagggtatt   701760
ttatttttat aattgaaaga cgtgaatgat atgaacatgt ccttgcgggt gcttaggaaa   701820
aaaattataa gtatgtcaag tttaagaaaa acttgattgt tggaggattt tttagatgaa   701880
cgaatttgaa gatttgctaa atagcgttag tcaagttgag actggtgatg ttgttagtgc   701940
tgaagtattg acagttgatg cgactcaagc taacgttgca atctctggaa ctggtgttga   702000
aggtgtcttg actcttcgcg aattgacaaa cgatcgtgat gcagatatca atgactttgt   702060
taaagtagga gaagtattgg atgttcttgt acttcgtcaa gtagttggta aagatactga   702120
tacagttaca taccttgtat ctaaaaaacg ccttgaagct cgcaaagcat gggacaaact   702180
tgttggtcgc gaagaagaag ttgttactgt taaaggaacg cgtgccgtta aaggtggact   702240
ttcagtagaa tttgaaggtg ttcgtggatt tatcccagct tcaatgttgg atactcgttt   702300
cgtacgtaac gctgagcgtt ttgtaggtca agaatttgat actaaaatca aagaagttaa   702360
cgctaaagaa aaccgcttca tcctttcacg tcgtgaagtt gttgaagcag ctactgcagc   702420
agctcgcgct gaagtattcg gtaaattggc tgttggtgat gttgtaactg gtaaagttgc   702480
tcgtatcaca agcttcggcg ctttcgtcga ccttggtggt gttgacggat tggttcactt   702540
gactgaattg tcacatgaac gtaatgtatc accaaaatca gttgtaactg ttggtgaaga   702600
aattgaagtg aaaatccttg atcttaacga agaagaagga cgtgtatcac tttcacttaa   702660
agcaacagta ccaggaccat gggatggcgt tgagcaaaaa ttggctaaag gtgatgtagt   702720
agaaggaaca gttaaacgtt tgactgactt cggtgcattt gttgaagtat tgccaggtat   702780
cgatggactt gttcacgtat cacaaatttc acacaaacgg attgaaaatc caaaagaagc   702840
tcttaaagtt ggtcaagaag ttcaagttaa agttcttgaa gttaacgcag atgcagaacg   702900
cgtgtcactt tctattaaag ctcttgaaga acgtccagcc caagaagaag gacaaaaaga   702960
agaaaaacgt gctgctcgtc cacgtcgtcc aagacgtcaa gaaaagcgtg atttcgaact   703020
tccagaaaca caaacaggat tttcaatggc tgatttgttt ggtgatatcg aactttaatc   703080
aaattgaaaa ttcacaaaat cctttgttta ctaaacaagg gatttttctg gctctttgtc   703140
aactgtagtg ggttgaagaa aagctaagct cgagaaagga caaattttgt cctttctttt   703200
ttgatattca gagcgataaa aatccgtttt ttgaagtttt caaagttccg aaaaccaaag   703260
gcattgcgct tgataagttt gatgagatta ttggtcgctt ccagtttggc gttagaatag   703320
tgtagttgaa gggtgttgac aagcttttct ttatctttga ggaaggtttt aaagacagtc   703380
tgaaaaatag gatgaacctg cttaagattg tcctcaataa gtccgaaaaa tttctccggt   703440
tccttattct gaaagtgaaa cagcaagagt tgatagagct gatagtggtg tttcaagtct   703500
tccgaataac tcaaaagctt gtttaaaatc tctttattgg ttaagtgcat acgaaaagta   703560
ggacgataaa atcgcttatc actcagttta cgactatcct gttgtatgag cttccagtag   703620
cgcttgatag ccttgtattc atgagacttt cgatgaaact gattcatgat ttggacatgc   703680
acacgactca tagcacggct aagatgttgt acaatatgaa agcgatcaag aacgatttta   703740
gcattcggga gtgaaacagt ctgggagact gtttcagcct gagcctagaa atttgaaagc   703800
gaagttgtct agctaagtca tagtaagggc taaacatatc catagtaatg attttgacgc   703860
gacatcggac ggctctatca tatttaagaa agtgatctcg gatgatagct tgtgttctac   703920
cttcaagaac agtgatgata tcgagcttgt caaaatcttg cgcaataaag ctcatcttca   703980
tctcccgatt gaaacagtca ctccccggac tgtttcaacg tcccaggaca taatctcagg   704040
aagacgcgaa aaatcatgct caaagtgaga atcattgagc tttcgaatga cagttgaagt   704100
tgaaatggcc agctgatgag caatatcggt catagaaatc ttctcaatca acttttgcgc   704160
aattttttgg ttgataatac gaggaatttg gtgatttttc ttgacgatag aagtttcagc   704220
gaccatcatt tttgaacagt gatagcactt gaaacgacgc tttctaagta gaattctagt   704280
aggcatacca gttgtctcaa ggtaaggaat cttagacggt ttttgaaagt catatttctt   704340
caattggttt ccgcactcag ggcaagatgg ggcgtcgtag tccagtttgg cgatgatttc   704400
cttgtgtgta tctttattga tgatgtctaa aatctggata ttagggtctt taatgtctag   704460
taattttgtg ataaaatgta attgttccat atgaatcttt ctaatgagtt gtttggtcgc   704520
ttttcattat aggtcatatg ggactttttt tctacaataa aataggctcc ataatatcta   704580
taagggattt acccactaca aatattatag agccaaaaat cctttgttta ctaaacaagg   704640
gatttttctt ttgtctctgc tccttttttg atataatagt tctatgttaa aatcagaaaa   704700
acaatcacgt tatcaaatgt taaatgaaga attgtccttc ctattggaag gcgaaaccaa   704760
tgttttggct aatctttcca acgccagtgc tctcataaaa tcacgttttc ctaataccgt   704820
atttgcaggc ttttatttgt tcgatggaaa ggaattggtt ttaggcccct tccaaggagg   704880
tgtttcctgc atccgtattg cactaggcaa gggtgtttgt ggtgaggcag ctcactttca   704940
ggaaactgtt attgttggag atgtgacgac ctatctcaac tatatttctt gtgatagtct   705000
agctaaaagt gaaattgtgg tgccgatgat gaagaatggt cagttacttg gagttctgga   705060
tctggattct tcagagattg aggattacga tgctatggat cgagattatt tggaacaatt   705120
tgtcgctatt ttgcttgaaa agacagcatg ggactttacg atgtttgagg aaaaatctta   705180
atgtatcaag cactttatcg aaaatataga agtcaaaact tctcccagtt agttggtcaa   705240
gaagttgtgg ctaagactct taaacaagcg gtggagcaag agaaaataag tcacgcttat   705300
cttttttctg gtcctcgtgg aacgggaaaa accagtgttg ctaaaatctt tgccaaggct   705360
atgaactgtc ccaatcaagt gggtggcgaa ccttgcaata actgctatat ttgtcaagca   705420
gtgacggacg gtagtttaga agatgtcatt gaaatggatg cagcttctaa taatggggta   705480
gatgaaattc gcgaaattcg tgataaatct acctatgcgc ctagccttgc tcgttataag   705540
gtttatatca tagatgaggt tcacatgctg tctacagggg cttttaatgc cctcctaaag   705600
acgctggaag aaccaacaca gaatgtagtc tttattttgg ccactactga attgcacaag   705660
attcctgcta ctattctatc ccgtgtgcaa cgttttgagt ttaaatcaat taagacacag   705720
gatattaagg aacatattca ctatatctta gaaaaagaaa atatcagttc tgaaccagag   705780
gctgtggaaa tcattgccag acgggcggaa ggtggaatgc gggacgcctt gtctattttg   705840
gatcaagccc tgagtttgac acagggaaat gagctgacga ctgctatctc tgaagaaatt   705900
actggcacca ttagcctatc agccttggat gattatgtgg cggccttgtc tcaacaggat   705960
gttcccaaag ctttgtcttg cttgaatctt ctttttgaca atggtaagag catgactcgt   706020
tttgtgaccg atcttttgca ctatttaaga gacttgttaa ttgttcaaac agggggagca   706080
aatactcatc atagttcagt ctttgtagaa aatttggcac ttcctcaaaa aaatctgttt   706140
gaaatgattc gcttagcaac agtgagttta gcagatatta agtctagttt gcaacccaag   706200
atttatgctg aaatgatgac cgtccgtttg gcggaaatca agtccgaacc agctctatca   706260
ggagcggttg aaaatgaaat tgctacgctg agacaggaag ttgcccgtct caaacaagag   706320
ctttctaatg taggtgcggt tcctaaacaa gttgcaccag ctcctagtcg accagctacg   706380
ggcaaaacag tctatcgtgt cgatcgcaat aaagtgcaat ctatcttaca agaggccgtc   706440
gaaaatcctg atttagcacg tcaaaattta attcgtttgc agaatgcctg gggagaggta   706500
attgaaagtc taggtgggcc ggacaaggct ctgctagttg gttctcaacc ggttgctgcc   706560
aatgaacacc atgctattct tgcttttgag tctaacttca atgctggtca aactatgaaa   706620
cgagacaatc tcaataccat gtttggtaat atcctcagtc aggcggcagg tttttcacct   706680
gagattttag ctatttccat ggaggaatgg aaagaagttc gcgcagcctt ttcagccaaa   706740
gccaaatctt ctcaaactga aaaagaagta gaagaaagcc tgattccaga aggatttgaa   706800
tttttggctg ataaagtgaa ggtagaggaa gactaaagaa agatttcatg atacaataag   706860
tttatgaata aacaacaatt tattattatg gcgctgttta cagctgctga gacctatttt   706920
ttcaatgaag cctggatgac tggccgctat attatggcag ccttttgggc aattttactc   706980
tttagaaatt tccgagtcag ttatgtgatg ggcaaaatcg ttgatgtcat cgatcagcat   707040
tttaatagga aagactagcc ctcagcttcc agacaaaatc aaagcctttt aggctttttt   707100
ttgttatact agaaaagtat atttatagaa tttttgctct atttctgggg aaatcagacg   707160
tttttctagt aagtactgta aaagttttga aaaagaaagg aactatcatg tcagtattag   707220
agatcaaaga tcttcacgtt gagattgaag gaaaagaaat tttaaaaggg gttaacctga   707280
ccctgaaaac aggagaaatt gccgctatca tgggaccaaa tggtacaggt aaatcgactc   707340
tttctgccgc tatcatggga aatccaaact atgaagtaac taaaggtgaa gttttgtttg   707400
atggcgtaaa catccttgag ttggaagtgg atgagcgtgc gcgtatggga cttttccttg   707460
ctatgcaata cccatcagaa atccctggaa ttaccaatgc tgagtttctt cgtgccgcta   707520
tgaatgcggg taaagaagat gatgagaaga tttcagttcg tgagtttatt actaagctag   707580
atgaaaaaat ggaattgctc aacatgaaag aagaaatggc agagcgttac ctcaacgaag   707640
gcttctctgg tggtgagaaa aaacgcaatg aaattcttca acttttgatg ttggagccaa   707700
catttgctct tttggacgag attgactcag gtcttgatat tgacgctctt aaagttgtgt   707760
ctaaaggtgt caatgccatg cgtggtgaag gttttggtgc tatgatcatc actcactacc   707820
aacgtctttt gaactatatc acacctgatg tggtacacgt gatgatggaa ggtcgtgttg   707880
tcctttctgg tggtccagaa ttggctgcgc gtttggaacg tgaaggatac gcaaaattag   707940
ctgaagaact tggctacgac tacaaggaag aattgtaatt ccctcgtatc ttttaggaga   708000
agtaaatgac tagagaaaat attaaacttt tttcagaaat gcacgctgaa ccaagctggt   708060
tggctgatct ccgtcaaaaa gcttttgaca agattgagac tttggaatta ccagttattg   708120
agtgtgtcaa attccaccgt tggaatctgg gtgatggaac gattacagaa aatgagccat   708180
cagcaaatgt tccagatttc acagctttag atcatcactt gaagttggtg caagtaggaa   708240
ctcaaactgt tttcgaacaa actccagttg agttagctga acagggtgtt gtcttcacag   708300
actttcactc agctttagaa gaaattccag agctgatcga agaattcttc atgtcatctg   708360
ttaagtatga tgatgacaag ttggcggctt accacacagc ttactttaac agtggtgctg   708420
tactctatat tccagataac gtagaaatca cagagccaat tgaaggaatt ttctaccaag   708480
atagcgatag caatgtgccg tttaacaagc atattatgat tatcgttggt aaaaattcta   708540
agattagtta tctggagcgt ttagagtcac gcggtgaagg aagtgacaaa gcaactgcca   708600
atatcacagt ggaagtgatt gcacgttctg gtgcgcaagt caagtttgct gctatcgacc   708660
gtctaggtga aaacgtcact gcctacatta gccgtcgtgg taaattaggc aacgatgcaa   708720
gtattgactg ggctatcggt gtcatgaacg aaggaaatgt cgttgctgat tttgatagtg   708780
acttgattgg taatggtagc catgctgacc tcaaggttgt agctctttca agtggtcgtc   708840
aggtacaagg gattgatact cgtgtaacta actatggctg caactcaatc ggaaacattc   708900
tacaacatgg ggttatcctt gaaaaagcaa ctttgacttt caatggtatc ggccacatca   708960
tcaagggtgc taagggagca gatgcgcaac aagagagccg tgttctcatg ctttcagacc   709020
aagcgcgttc agatgctaac ccaattcttt tgattgatga aaatgacgta actgcaggcc   709080
atgcagcctc tattggtcag gtagatccag aagatatgta ctacctcatg agtcgtggct   709140
tggataaggc aactgcagag cgtttggttg ttcgtggttt ccttggatct gttatcgtgg   709200
agattccagt caaggaagtt cgtgatgaaa tgattgcaac tatcgaagag aaattgtcaa   709260
aacgctaagg ggcagcctat gttagatgta gaagcgattc gcaaggattt tccaatttta   709320
gatcagattg tcaatgatga acctctggtc tatctggaca atgctgcgac gacacaaaaa   709380
ccactagtag ttctgaaagc tattaacagc tactatgagc aggacaatgc caatgttcac   709440
cgtggtgtcc ataccttagc ggaacgagcg acagcttctt atgaagctgc tcgtgaaacc   709500
attcgtaagt ttattaatgc aggctctaca aaggaagttc tctttaccag aggaacgaca   709560
accagcctta actgggtggc acgctttgct gaggaaattc tcactgaggg agaccaggtc   709620
ttgatttcag taatggaaca ccattctaat atcattccat ggcaggaagc ttgtcgaaag   709680
actggagcag agcttgtcta tgtctatctt aaagacggtg ccttggatat ggaggatttg   709740
cgagctaaat tgactgataa ggttaaattt gtttccctag ctcatgcctc caatgttctt   709800
ggtgtggtca atccgatcaa ggaaatcact caattagccc accaagttgg ggcaattatg   709860
gtagtggatg gtgctcaatc tacacctcat atgaagattg atgtccagga cttggatctg   709920
gactttttcg ccttttcggg tcacaagatg gctggtccga ctggtatcgg tgtcctttac   709980
ggcaaagaaa agtatcttga gcaaatgtct ccagtagaat ttggcggcga gatgattgat   710040
tttgtctacg agcaatttgc tagttggaag gaattgcctt ggaaatttga ggctggaacg   710100
ccaaatatgg caggagctat tggacttgcg actgcagttg attatctgga aaagattggt   710160
atggatgccg ttgaagctca tgaacaggaa ttgattgcgt acgtctatcc aaaactgcag   710220
gcaattgagg gattgaccat ttacggttct caggatttgg ctcaacgttc gggtgttatt   710280

gcctttaacc taggtgatct ccatcctcac gatcttgcga cggctctgga ttatgaagga   710340
gtggctgttc gtgctggtca ccattgtgcg caacccttgc ttcagtattt ggaagtccca   710400
gcaacagctc gtgcaagttt ttatatctac aataccaagg cagattgcga caaactagtc   710460
gatgccctac aaaagacaaa ggagtttttc aatggcactt tctaaactag atagccttta   710520
tatggcagtg gtagcagacc attcgaaaaa tccacatcac caagggaagt tagaagatgc   710580
tgagcaaatc agtctcaaca atccgacttg tggggatgtc atcaacctct ctgtcaagtt   710640
tgatgcagag gaccgtttgg aagatattgc ttttctaaat tcaggatgca cgatttcaac   710700
tgcttctgct agtatgatga cagatgccgt tttaggaaaa accaaacaag aaattttaga   710760
actggcgact attttttctg aaatggttca agggcaaaaa gatgagcgtc aagaccaact   710820
tggagacgcg gcattcttgt caggtgttgc caaattccct caaagaatca agtgtgcaac   710880
cctagcttgg aatgccctta agaaaacaat tgaaaatcaa gaaaaacagt aagacaagtt   710940
tcttttgtct tatgaattat tagaaatgaa gaaagaaagg atactatggc tgaagaaaga   711000
gtagaaccaa aaccaattga ccttggtgaa tataaatttg gtttccatga cgatgtagag   711060
cctgtcttat cgacaggaaa aggactcaac gaaggtgtta ttcgtgaatt atctgctgct   711120
aagggtgagc ctgagtggat gttggagttc cgtttgaagt cttatgaaac cttcaaaaaa   711180
atgcccatgc aaacttgggg agcagacttg tcagagattg actttgatga cttaatctac   711240
taccaaaaac catctgacaa accagcccgt tcttgggatg atgtacctga aaagattaaa   711300
gaaacctttg aacgtatcgg gattccagaa gctgaacgtg cttatttagc aggggcttct   711360
gcccagtacg agtcagaagt ggtttaccac aacatgaagg aagagttcca aaaattaggt   711420
attatcttta cagatacaga ttccgcactc aaggaatacc cagacttatt taaacaatac   711480
tttgcgaagt tggtaccgcc gacagataac aagttggcag ccctcaactc agcagtatgg   711540
tcgggtggaa cttttatcta cgtgccaaaa ggtgtcaagg tagatattcc acttcaaact   711600
tatttccgta tcaataacga aaatataggt cagttcgaac gtaccttgat tatcgttgat   711660
gagggagcaa gcgtctacta cgtagaagga tgtacagcac caacatattc aagcaatagc   711720
ttacacgctg ccattgtaga aatttttgct ttggacggag cttatatgcg ttatacaact   711780
atccaaaact ggtctgataa cgtctataac ttggtaacaa agcgtgctaa ggctcaaaag   711840
gatgccactg ttgagtggat tgatggaaac ttgggtgcca aaacgactat gaaatatcca   711900
tctgtttacc ttgatggaga aggagcgcgt ggtaccatgc tctctatcgc ctttgctaat   711960
gcagggcaac accaagacac gggtgctaag atgattcaca atgctccaca taccagctcg   712020
tctattgtgt ctaaatccat cgctaaaggt ggaggaaagg ttgactaccg tggacaagtc   712080
acctttaaca agaactctaa gaaatctgtt tcccacattg aatgtgatac cattatcatg   712140
gatgacttgt cagcatcaga tactattcca tttaatgaaa ttcacaactc gcaagtggct   712200
ttggaacacg aagccaaagt atctaagatt tcagaagagc aattgtatta tctcatgagc   712260
cgtggattgt cagaatctga ggcaactgaa atgattgtca tgggatttgt agaacccttt   712320
acaaaagaac ttccaatgga atacgcagtt gagctgaacc gcttgattag ctatgaaatg   712380
gagggatcag ttggataaaa tttgatttta tactcttcga aaatctcttc aaaccacgtc   712440
agcatcgcct taccgtatgt atggttactg acttcgtcag tttcatctac aacctcaaaa   712500
cagtgttttg agcaacctgc ggctagcttc ctagtttgtt ctttgatttt gagtattaga   712560
tttactcaaa atcaaggatt ttgaagatga acttgtatca aaaaatcgcg gtttaaaatc   712620
gcgatttttt ataatttctc gttaacaaag cggacaaact gattccacca aacttttaag   712680
aagaaggctt tttcaatttt cttgtctgct accatttcga aactagggcg ctctgtggtg   712740
atgtaacctt gaccaatcaa gtccttgtct tcataagtca aatggccaac cactgttcca   712800
gcttcaagtg gtgctgggat tgctttggaa tcaggtgtga attgaacaga ttgggaagat   712860
tgattcccaa cacgttcgat tagatagata tcctctggag ccactgcagt tactgtatct   712920
tcttttccat cttgtacagg ggctttgcta tcttgatagg catcgccttg ttgaacgatt   712980
ttgcgaagtg taaatgtaga agaaatataa tccattaggg aagatgtagc tgtaaatcga   713040
gcgtaaggat tattgtcttg atgatctgca tttaaaacaa ctgtgatgac tctcatgcct   713100
ttttcgacag tagtaccaac aaaagactct ccagccttat ctgttgttcc tgtttttagc   713160
ccatcaaaac caccacggta agcaggcata ccttctaaca tgtagttggt tgaagtgatt   713220
gtcatcccag caaaagtaga agaaggtttt ttggtgattt ctaagacttg tgggtatttt   713280
ttgatgaggt tgcgagcaac gatagcgaca tcataagcac taagcttatt ttcctcatct   713340
tttttagaac ctgggtaaat gttatcccct agagtttcat tgttaagacc tgtcgtattg   713400
acaacagtgg catcctgaat tccccattcc aagagttttg cccgcatcat atcgacgaaa   713460
tctttttctg agccagcaat tttctcagct agggcaatag cggcgctgtt ggcactagat   713520
accagagttg cttcaagcaa ctcttcgaca gtataattac gggcctccat aggaatatta   713580
ctggcttcag aatttgtcgt caattgataa ggataatcag aaatatctac aggagtggag   713640
agggtaatac ttccgttttc caaagcttca tagaccagat aaacagtaat caattttgtt   713700
atggaagcaa tttcgacagg ttgcgttgca tccttctcat agagaatttt accagtattt   713760
gcctcaacag caatcgcatg tttagcggca atggtaaaat cttgagcaac agcagtagaa   713820
gcacccccta aaagagagac agttaacaaa gttaaaaata tttttttcat agtagtctta   713880
ttctatcata aagaaaaaaa atattcttgc tttaataatt catctgttaa gctttttgaa   713940
aatatggtaa aataaagtaa gggaggtaac tcatgtttcg tagaaataaa ttattttttt   714000
ggaccacaga aattttactc ttaaccatca tcttttacct atggagacag atggggtctt   714060
tgattaaccc ttttgttagc gtgcttaata caattatgat tccattttta ttagggggct   714120
ttttttatta tttgacaaac cctattgtta ctttcttaaa taaagtctgt aaactcaatc   714180
gtttgcttgg tattttaatt accttgtgta ctttggtctg gggaatggtc ataggtgttg   714240
tctatctctt acctattttg attaatcagt tatctagttt gattatatct agtcaaacta   714300
tttatagtcg agtacaagac ttaatcatag acttatctaa ttatcctgcg ctccagaatt   714360
tggatgtaga agctacaatt cagcagttaa acttatccta tgttgatatt cttcaaaata   714420
tcctaaatag cgtatcaaat agtgtgggga gcgtcttgtc agctcttatc agtactgttt   714480
tgattttgat tatgactcca gtttttttgg tttatttctt attagatgga cataaattct   714540
tgcccatgct tgaaagaacg attctaaaga gggatcgctt gcatattgca ggcttattaa   714600
agaatttaaa tgcgacgatt gctcgctata ttagtggagt ttcgattgac gcaatcatta   714660
taggttgttt ggcttatatt ggctatagta ttattggttt aaaatatgct ttagtttttg   714720
ccattttttc tggtgtagcc aatttaattc cttatgtggg gccaagtatt ggtttgattc   714780
ctatgatcat cgcaaatata ttcactgatc cccatagact gctgattgca gtgatttata   714840
tgcttgttgt tcagcaggta gatggcaata tcttatatcc tcgaatcgta ggaagtgtta   714900
tgaaggttca tccaatcacg attttagttt tacttttgtt gtcaagcaat atctatggtg   714960
tagttggaat gattgtcgca gtgccaacct attctatctt gaaagaaatt tctaagttct   715020
tatcccattt gtatgaaaat cataaaataa tgaaagaacg agaaagagaa ttagctaagt   715080
aaaagtcagg agaaccctga tttttcttta ctggaagtgg cctttagatt agaagactga   715140
aaataagtta aagtcttaaa ctaattttca cagctaagaa tagtagaagt taatctgata   715200
aaaatcgaaa aaaccagtgg aattctgtgt cagggtaagt tccactggtt ttcatagtct   715260
attaaagttc gaatgaaacc tatttatagt agattgaaac tagaatagta cacctctaat   715320
tctaaaacat tgttagaaat cgatttgact gtcctgatct attcgttcta ttcttatttc   715380
attttactat attttggtgc aataagtgaa aagtagtccg aataatataa ggattgattt   715440
tatagttttt aaactcaaat gaattgaaat aaagagagta cgaaaattct catctgaaag   715500
tattttagaa taattctctt cgtgaatttc ttcaaaacag atagcttcat cttaggtatg   715560
tgatttcttt ttgcattttt gagttagata aggtataatg attttattgt cttttggggt   715620
cgttacggat tcgacaggca ttatgaggca tattttgcga ctcgtgtggc gacgtaaacg   715680
ctcagttaaa tataactgca aaaaataaca cttcttacgc tctagctgcc taaaaaccag   715740
caggcgtgac ccgatttgga ttgctcgtgt tcaatgacag gtcttattat tagcgagata   715800
cgattaagcc ttgtctagcg gtttgataag agattgatag actcgcagtt tctagacttg   715860
agttatgtgt cgaggggctg ttaaaataat acataaccta tggttgtaga caaatatgtt   715920
ggcaggtgtt tggacgtggg ttcgactccc accggctcca ttattccttt gcattctttt   715980
gcattccttg gtaaaacgtt gttaaatcaa cgttttttat ttttatcttt ggtattcctt   716040
tgcattcttt tgctaaaaag ggagtcacaa acagacccta ttttaaaaaa ggatagaaaa   716100
aaggatacaa catttgtcgc atcctaaaaa taatcttttt tcgacggaag acatgggatt   716160
cgaacccacg cacgctatta cacgcctacc gcgtttccaa cacggcctct taagcctctt   716220
gagtaatctt ccaatactta ctcaaatagt ctaccataaa ggctcttatc ttgcaataaa   716280
aattctagaa ataagaaaaa tgatagattt tgaaagaaaa tgataaaaaa tgcttgactt   716340
cgaaagaaag tatgatagaa tgaatagtgt aaacgataac aggaggtgat tcagtgttaa   716400
aaacagaacg taaacaacta attttagagg agttaaatca acatcatgta gtttctctag   716460
aaaaattagt tagtttgcta gaaacgtcag aatcaacggt tcgaagagac ttggatgagt   716520
tggaagcgga aaacaagctt cgtcgtgtgc atggtggagc agaactcccc tactccttac   716580
aggaagaaga aaccattcaa gaaaaatctg tcaaaaacct tcaagaaaag aaattgctgg   716640
ctcagaaagc agcctctctc attaaagaaa aagatgtcat ctttatcgat gctggaacaa   716700
caactgcttt tttgattcat gaattggtca ataagaatgt tacagttgtg accaactcca   716760
ttcaccatgc cgctcagttg gttgaaaagc agattccaac tgtcatggtt ggaggaaacg   716820
tcaagacggc gacagatgct agtatcgggg gcgttgctct taaccagatt aaccaattgc   716880
actttgaccg tgcctttatc ggaataaatg gtgttgacga tggctattat acgactcctg   716940
atatggagga gggagctgtg aaaagagcta ttttggagaa tgccaagcag acctacgtct   717000
tggtggattc gtcaaaaatt ggacaaactt gctttgccaa ggtagcccca ctcaaacgcg   717060
ctatcgttat cactagtcaa gggcatgagc tcttgcaggt tattaaggag aaaacggagg   717120
taatagaagt atgatttata cagtcacact caatccatcc attgactata tcgttcgttt   717180
ggaccaagtc aaagttggta gtgtcaatcg tatggacagt gatgataagt ttgctggtgg   717240
gaaaggaatc aatgtcagcc gtgtcttgaa acgtttgaat ataccaaata cagcgacggg   717300
atttatcggt ggctttactg gtaaatttat cacagatact ttagcagagg aagaaatcga   717360
gacacgtttt gtccaggtgg cagaagatac tcgtatcaat gttaaaatca aagcagacca   717420
agaaacagaa atcaacggaa cgggtccaac tgttgaatcg gttcagctag aagaattgaa   717480
agctatttta tctagtctga cagcagaaga tacagttgtc tttgcaggtt caagtgctaa   717540
aaatctaggc aatgttatct ataaggattt gatttccttg acgcgccaga ctggtgcgca   717600
agtggtctgt gactttgaag gacagacctt aattgatagt ttggactacc agcctcttct   717660
tgtaaaacca aacaatcatg aacttggagc gatttttggg gttaaactcg aaagtttaga   717720
tgaaattgag aaatacgctc gtgagttact ggctaagggt gctcaaaatg ttattatctc   717780
tatggctggt gatggtgccc ttcttgtcac atctgaggga gcttacttcg ctaaaccaat   717840
caaaggaaca gtcaaaaatt cagttggagc tggtgattct atggttgctg gattcacagg   717900
tgaatttgtc aaatcaaaag acgtagtaga agccttcaaa tggggagtgg cttgcggaac   717960
ggcaactacc ttctcagatg acttggcaac ggcggaattt attaaagaaa catatggaaa   718020
agttgaggta gaaaaacgat gaaaattcaa gacctattga gaaaagatgt catgttgcta   718080
gatttgcagg caactgaaaa aacagctgtc atcgacgaga tgattaaaaa tttgacagac   718140
cacggttatg taacagattt tgaaacattt aaagaaggaa ttttggcgcg tgaagctttg   718200
acttctactg gtttgggtga tggaatcgca atgcctcaca gcaaaaacgc tgctgtcaaa   718260
gaagcgacag ttctatttgc taagtcaaat aagggtgttg actacgagag cttggatgga   718320
caagcaactg acctcttctt catgattgca gctccagaag gtgccaatga tactcacttg   718380
gcagccttgg cagaattgtc tcaatacttg atgaaagacg gttttgcaga caaacttcgt   718440
caagcaacat ctgcagacca agttatcgaa ctttttgacc aagcttcaga aaaaactgag   718500
gaacttgttc aagcacctgc taatgactct ggtgacttta tcgtagctgt tacagcttgt   718560
acaacaggta ttgcccacac ttacatggcc caagaagccc ttcaaaaagt agctgctgaa   718620
atgggggttg gtatcaaggt cgaaaccaac ggtgctagcg gtgttggaaa tcaactaact   718680
gcagaagata tccgtaaggc taaagctatt atcattgcag cagacaaggc cgttgaaatg   718740
gatcgatttg atggaaaacc attgatcaat cgtccagttg ctgacggtat ccgtaagaca   718800
gaagagctaa ttaacttggc tctttcagga gatactgaag tctaccgtgc cgctaatggt   718860
gccaaagctg caacagcctc taacgaaaaa caaagccttg gtggtgcctt gtacaaacac   718920
ttgatgagtg gtgtatctca aatgttacca ttcgttatcg gtggtggtat catgattgcc   718980
cttgccttct tgattgacgg tgctttgggt gttccaaatg aaaaccttgg caatcttggt   719040
tcttaccatg agttagcttc tatgttcatg aaaattggtg gagctgcctt tggtttgatg   719100
cttccagtct ttgcgggtta tgttgcctac tctattgctg aaaaaccggg tttggtagca   719160
ggtttcgtgg ctggtgctat tgccaaagaa ggttttgcct ttggtaaaat tccttatgcc   719220
gcaggtggtg aagcaacttc aactcttgca ggtgtctcat ctggtttcct aggtgccctt   719280
gttggtggat ttatcgcagg tgccttggtt cttgccatca agaaatacgt taaagttcct   719340
cgttcactcg aaggtgctaa atcaatcctt ctattgccac ttcttggaac aatcttgaca   719400
ggatttgtta tgctagctgt gaatatccca atggctgcaa tcaacactgc tatgaatgac   719460
ttcctaggcg gtcttggagg aggttcagct gtccttcttg gtatcgtcct tggtggaatg   719520
atggctgttg acatgggtgg accagttaat aaagcagctt atgtctttgg tacaggtacg   719580
cttgcagcaa ctgtttcttc aggtggttct gtagccatgg cagcagttat ggctggagga   719640
atggtgccac cacttgcaat ctttgtcgca actcttcttt tcaaagataa atttactaag   719700
gaagaacgta actctggttt gacaaacatc atcatgggct tgtcatttat cactgaggga   719760
gcgattccat ttggtgccgc tgacccagct cgtgcgattc caagcttcat ccttggttca   719820
gcagtagcag gtggactcgt tggtcttact ggtatcaaac tcatggcgcc acacggagga   719880
atcttcgtta tcgcccttac ttcaaatgct ctcctttacc tcgtttctgt cttggtagga   719940
gcaatcgtaa gtggtgtggt ttatggttac ctacgcaaac cacaagcata aaaaatagaa   720000
aaatgaaaag attggaccgt ttggtgcagt ctttttctct tcccgaaatg cctgtgaaat   720060
atggtataat agaagaatgg caaacaagaa tacaagtaca acaagacgga gaccgtctaa   720120
agcagaactg gaaagaaaag aagcgattca acgaatgttg atttcgttag gaattgcgat   720180
tttattgatt ttcgcagcct tcaaattagg ggctgcaggt ataacccttt ataatttaat   720240
tcgcttgcta gtgggtagcc tagcttatct ggcgatattc ggcctattaa tctatctctt   720300
ctttttcaag tggatacgaa aacaggaagg actcttatct ggctttttca ccatatttgc   720360
tggcttactc ttgatttttg aggcctactt ggtttggaaa tatggtttgg acaagtccgt   720420
tctaaaaggg accatggctc aggttgtgac agatctgact ggttttcgaa cgactagctt   720480
tgctggaggg ggcttgatcg gggtcgctct ttatattcca acagcctttc tcttttcaaa   720540
tatcggaact tactttattg gttctatctt gattttagtg ggttctctcc tagtcagccc   720600
ttggtctgtt tacgatattg ctgaattttt cagtagaggc tttgccaaat ggtgggaagg   720660
gcacgagcgt cgaaaagagg aacgctttgt caaacaagaa gaaaaagctc gccaaaaggc   720720
tgagaaagag gctagattag aacaagaaga gactgaaaaa gccttactcg atttgcctcc   720780
tgttgatatg gaaacgggtg aaattctgac agaggaagct gttcaaaatc ttccacctat   720840
tccagaagaa aagtgggtgg aaccagaaat catcctgcct caagctgaac ttaaattccc   720900
tgaacaggaa gatgactcag atgacgaaga tgttcaggtc gatttttcag ccaaagaagc   720960
ccttgaatac aaacttccaa gcttacaact ctttgcacca gataaaccaa aagatcagtc   721020
taaagagaag aaaattgtca gagaaaatat caaaatctta gaagcaacct ttgctagctt   721080
tggtattaag gtaacagttg aacgggccga aattgggcca tcagtgacca agtatgaagt   721140
caagccggct gttggtgtaa gggtcaaccg catttccaat ctatcagatg acctcgctct   721200
agccttggct gccaaagatg tccggattga agcaccaatc cctgggaaat ccctaatcgg   721260
aattgaagtg cccaactccg atattgccac tgtatctttc cgagaactat gggaacaatc   721320
gcaaacgaaa gcagaaaatt tcttggaaat tcctttaggg aaggctgtta atggaaccgc   721380
aagagctttt gacctttcta aaatgcccca cttgctagtt gcaggttcaa cgggttcagg   721440
gaagtcagta gcagttaacg gcattattgc tagcattctc atgaaggcga gaccagatca   721500
agttaaattt atgatggtcg atcccaagat ggttgagtta tctgtttaca atgatattcc   721560
ccacctcttg attccagtcg tgaccaatcc acgcaaagcc agcaaggctc tgcaaaaggt   721620
tgtggatgaa atggaaaacc gttatgaact ctttgccaag gtgggagttc ggaatattgc   721680
aggttttaat gccaaggtag aagagttcaa ttcccagtct gagtacaagc aaattccgct   721740
accattcatt gtcgtgattg tggatgagtt ggctgacctc atgatggtgg ccagcaagga   721800
agtggaagat gctatcatcc gtcttgggca gaaggcgcgt gctgcaggta tccacatgat   721860
tcttgcaact cagcgtccat ctgttgatgt catctctggt ttgattaagg ccaatgttcc   721920
atctcgtgta gcatttgcgg tttcatcagg aacagactcc cgtacgattt tggatgaaaa   721980
tggagcagaa aaacttcttg gtcgaggaga catgctcttt aaaccgattg atgaaaatca   722040
tccagttcgt ctccaaggct cctttatctc ggatgacgat gttgagcgca ttgtgaactt   722100
catcaagact caggcagatg cagactacga tgagagtttt gatccaggtg aggtttctga   722160
aaatgaagga gaattttcgg atggagatgc tggtggtgat ccgctttttg aagaagctaa   722220
gtctttggtt atcgaaacac agaaagccag tgcgtctatg attcagcgtc gtttatcagt   722280
tggatttaac cgtgcgaccc gtctcatgga agaactggag atagcaggtg tcatcggtcc   722340
agctgaaggt accaaacctc gaaaagtgtt acaacaataa aaaaatagct tctttccaag   722400
tttggaggga agctatttta gtggctattg attgctttta ttttctgaag ttggcgcatt   722460
ggactgtttt tcgttttcag tagcaggttt acttgaagca ggagtagaag agtcctgagt   722520
tgctgttttc tgatcttctt ttttctcttc cttgacgcta gattttggtg tttcctcttg   722580
ctgtgttttt tcttgactag tgttagtctc tttagttgga ctggtgtttt ccttagggga   722640
ttccttttgg atttctttga caatggttgt cgtctggctt gtcgtaggtt cttttttaat   722700
atttttgtta ttatccaagg cgttcataat cgtgatactt gcggtaatca agccaaggat   722760
actagcgatt gtagcaacgg ttttttgaaa gactgtaaag ccttttttga tgtgttctgt   722820
ttttggtttt gaagttctac gatagttaga catacattct ctcctttgat tatgatttat   722880
tatactctgt ttctttaaaa aaatcttaaa aaaagagaaa tttccctttc ttgtcgcaag   722940
ctccgtttca tgatacaata gaggaagtga ttttagaaag cgtgagaaac atgatttact   723000
ttgataattc agcgacgacc aagccttatc ctgaagccct tgaaacctat atgcaggtcg   723060
cttcaaaaat tttaggaaac ccatctagtc tccatcgttt gggagaccaa gcaacacgaa   723120
tcttagatgc ttctcgccaa cagattgcag atttaatcgg taagaaaagc gatgaaatct   723180
tctttacctc gggtggaaca gaaggggata actggcttat caagggtgtg gcctttgaaa   723240
aagctcagtt tggcaagcac atcattgttt cagccattga acatccagca gtcaaagagt   723300
cagccctctg gttgaaaagt caaggatttg aagtggattt tgctccagtt gataagaaag   723360
gcttggtcga tgttgaggcg ttagcaggtt tgatacggca tgatacaatc ctcgtttcca   723420
tcatggctgt gaacaatgaa atcggctcta tccaacctat tgaggctatt tcagaattct   723480
tggcagacaa gccgactatt tccttccacg ttgatgcggt tcaggcgctt gccaaaattc   723540
cgactgaaaa gtatctgaca gaacgggtgg attgcgcgac tttctctagt cacaagttcc   723600
acggggttcg aggtgttggc tttgtctata tcaaatctgg caagaagatt acacctcttc   723660
ttacaggtgg tggccaggag cgagattatc gttcgacaac tgaaaatgtg gcagggattg   723720
cagcgacagc caaggccctc cgtttgtcta tggaaaagct agatatcttt aggagcaaga   723780
ctgggcagat gaaggcagtg attcgccaag ctcttctgaa ctatccggat atttttgtct   723840
tttcagatga ggaaaacttt gcacctcata ttctgacttt tggaatcaaa ggtgttcgag   723900
gtgaagtcat cgttcacgcc tttgaagact atgatatttt catctcaaca acctcagctt   723960
gttcatctaa ggcaggaaaa ccagccggta ccttgattgc catgggagtg gacaaagata   724020
aggccaagtc agctgtgcgt cttagcctag acttggaaaa tgatatgagt caggtcgagc   724080
agtttttgac caagttaaaa ttgatttaca atcaaactag aaaagtaaga taggagcatt   724140
catgcagtat tcagaaatta tgattcgcta cggagagttg tcaaccaagg gtaaaaaccg   724200
tatgcgtttc atcaataaac ttcgtaataa tatttcggac gttttgtcta tctataccca   724260
agttaaggta acagcagatc gcgaccgtgc ccacgcttac ctcaatggag ctgattacac   724320
agcagttgca gaatctctca aacaagtttt tggaattcaa aacttttctc ctgtttataa   724380
ggttgaaaaa tctgtagaag ttttgaagtc ttctgtccaa gagattatgc gggacatcta   724440
caaggaaggt atgaccttta agatttctag caagcgtagc gaccacaact ttgaacttga   724500
tagtcgtgaa ctcaaccaaa cacttggagg ggctgtattc gaagccattc caaatgtgca   724560
agttcaaatg aaaagtcctg acatcaatct tcaggtggag attcgtgaag aagcagccta   724620
tctttcttat gaaaccattc gtggggctgg tggtttgcca gttggaactt caggtaaagg   724680
gatgctcatg ttgtcaggag ggattgactc acctgtagca ggttatcttg ctcttaagcg   724740
tggggtggat atcgaggcag ttcactttgc tagtccacca tatactagtc ctggtgccct   724800
caagaaagcg caggacttga cccgtaaatt gaccaagttt ggcggaaata tccagtttat   724860
agaggtgcct ttcacagaga ttcaagagga aatcaaagcc aaagcgccag aagcttattt   724920
gatgactcta actcgtcgct ttatgatgcg gattactgac cgtattcgtg aggtacgaaa   724980
tggtttggtt atcatcaatg gggaaagtct aggtcaagta gccagccaaa cccttgaaag   725040
tatgaaggct atcaatgctg ttaccaacac tcccatcatt cgtcctgtgg ttaccatgga   725100
caagttggaa atcattgaca tcgcccagga aatcgatacc tttgacattt caatccaacc   725160
gtttgaagac tgttgtacca tttttgcacc agatcgtcca aaaacaaatc ctaaaattaa   725220
gaatgcggag cagtacgaag cgcgtatgga tgttgaaggc ttggttgagc gagcagtggc   725280
tggaatcatg attactgaaa tcacacctca agccgaaaaa gatgaagttg atgacttgat   725340
tgacaatctg ctctaattca gaaaatccaa aagaatagcg aaaatcagta aaaaaagtta   725400
gttttttctc taaaaacagg taaaaaacta acttttttta tttttatgat ataatgatat   725460
aaaattttga atatagagag ttttctgaca atgaatcaat cctactttta tctaaaaatg   725520
aaagaacaca aactcaaggt tccttataca ggtaaggagc gccgtgtacg tattcttctt   725580
cctaaagatt atgagaaaga tacagaccgt tcctatcctg ttgtatactt tcatgacggg   725640
caaaatgttt ttaatagcaa agagtctttc attggacatt catggaagat tatcccagct   725700
atcaaacgaa atccggatat cagtcgcatg attgtcgttg ctattgacaa tgatggtatg   725760
gggcggatga atgagtatgc ggcttggaag ttccaagaat ctcctatccc agggcagcag   725820
tttggtggta agggtgtgga gtatgctgag tttgtcatgg aggtggtcaa gccttttatc   725880
gatgagacct atcgtacaaa agcagactgc cagcatacgg ctatgattgg ttcctcacta   725940
ggaggcaata ttacccagtt tatcggtttg gaataccaag accaaattgg ttgcttgggc   726000
gttttttcat ctgcaaactg gctccaccaa gaagccttta accgctattt cgagtgccag   726060
aaactatcgc ctgaccagcg catcttcatc tatgtaggaa cagaagaagc agatgataca   726120
gacaagacct tgatggatgg caatatcaaa caagcctata tcgactcgtc gctttgctat   726180
taccatgatt tgatagcagg gggagtacat ctggataatc ttgtgctaaa agttcagtct   726240
ggtgccatcc atagtgaaat cccttggtca gaaaatctac cagattgtct gagatttttt   726300
gcagaaaaat ggtaagttaa gaaaggaaaa aacgaaatgc atattgaaca tcttagccac   726360
tggagtggtc atcttaaccg tgaaatgtac cttaaccgtt atggacatgg tgggattcca   726420
gttgtggtct ttgcttcatc aggtggtagt cacaacgaat actatgattt tggcatgatt   726480
gatgcctgtg cttcctttat cgaggaaggc cttgtccagt tctttaccct atctagtttg   726540
gatagtgaga gctggttggc tacttggaaa aatgctcatg accaagcgga aatgcaccgt   726600
gcctacgaac gttatgtgat tgaggaggcc attcttttat caagcacaag acaggttggt   726660
ttgatggcat gatgacgaca ggttgctcta tgggagccta tcatgcactc aatttcttcc   726720
tccagcatcc agatgtcttt accaaagtga ttgctctcag tggtgtttac gacgcacgtt   726780
tctttgtcgg tgattactac aacgatgatg ctatttacca aaactcgcca gtagattata   726840
tttggaacca aaacgacggc tggtttattg accgttaccg tcaggcagag attgtgctgt   726900
gtacggggct tggagcctgg gaacaagatg gtttgccatc cttttacaag ctcaaagaag   726960
cctttgacaa gaaacaaatt ccagcctggt ttgctgaatg gggacatgat gtcgcccatg   727020
actgggaatg gtggcgtaaa caaatgcctt atttcctcgg taatctctat ttataaaagg   727080
agttacctat gaattacctt gttatttctc cctactatcc acaaaacttt caacagttta   727140
ccatcgaact agctaataaa ggcatcacag tcttgggaat tggtcaagag tcttacgagc   727200
aattggatga gcccttgcgc aatagcttga ccgagtattt tcgtgttgat aatcttgaga   727260
acatagatga agtcaaacgt gcagttgctt ttctctttta taaacatggt ccaattggcc   727320
gcatcgagtc tcacaatgaa tactggcttg agctagacgc aacactcaga gaacaattca   727380
atgtttttgg tgccaaacca gaggatctca aaaagacgaa atataagtct gaaatgaaga   727440
aacttttcaa aaaagcaggt gttcctgtgg tacctggagc tgttatcaag acggaagcag   727500
atgttgatca agcagtgaaa gaaatcggtc ttccaatgat tgccaaacct gataatggag   727560
tgggagcagc cgcaaccttt aaacttgaga cagaagacga tatcaatcac ttcaagcaag   727620
aatgggacca ttcaaccctt tatttctttg aaaaatttgt cacttccagc gaaatctgta   727680
cctttgacgg gctcgtggac aaggatggaa agattgtctt ctcaacaacc tttgactacg   727740
cctatacacc gcttgacctc atgatttata agatggacaa ttcttattat gtgctcaagg   727800
atatggatcc taaactgcgc aagtatgggg aagcaattgt caaagaattt ggtatgaaag   727860
aacggttttt ccatattgag ttcttccgtg agggggacga ttatattacc atcgagtaca   727920
ataaccgccc tgcaggtggt tttaccattg atgtttataa ctttgctcat tccttggacc   727980
tttatcgtgg ctatgcagct attgtcgcag gagaggagtt cccggcgtca gactttgaaa   728040
ctcagtattg tttggctact tctcgccgtg caaatgctca ctatgtttat tcagaagagg   728100
atttgcttgc caaatatagc cagcagttca aggttaaaaa agtcatgcca gctgccttcg   728160
cggaacttca aggagattac ctgtatatgc tgaccactcc gagtcgacaa gaaatggagc   728220
agatgattgc agatttcgga caacgtcaag aataagaact atcggattaa ggaaattaac   728280
tcccttaatc cttttgtttt gtctgataaa aaataagagc atcccaacaa ggtagctatc   728340
ataaaacttg ttcgataact atttgaagca ggattaggtg gtcagaaatt aaattttaat   728400
atttcaattg agtcatagta ttgtgtttgc gtatccttaa atcagctaaa aggatccatg   728460
acgacaccta tacgatatag ttttcaagat accaaacaag tctattaata ttcaatgaaa   728520
atcaaagagc aaactaggaa gctagccgca ggtttctcaa aacactgttt tgaggttgtg   728580
gatagaactg acagagtcag tatcatatac tacggcaagg tgaagctgac gtggtttgaa   728640
gagattttcg aagagtataa aatattcagg tgacgcatag atatagttaa ttgaagcttt   728700
gtttgaaatc tgataaaata atgatattac taagttttaa aaactaaaga aaagggaaga   728760
tatgattaca ggcgaattaa aaaataaaat cgatcagctg tgggaaattc tttggacaga   728820
aggaaacgca aatcctttaa caaatattga acagttgact tatctcttat ttatgaaaga   728880
tttggatagt gtcgagcttg gacgtgaaag tgatgctgaa tttctaggga ttccttatga   728940
gggagttttt ccaaaagata aacctgaata ccgttggtca acttttaaaa atataggaga   729000
tgctcaggaa gtttatcgtt taatgactca ggagattttt ccgtttatta aaaatctcaa   729060
gggggataca gatgatacag ccttttcacg atatatgcga gaagctattt ttcaaataaa   729120
taaacctgct acgcttcaaa aggcaatttc tatcttagat gtttttccaa ctaggggatt   729180
agatgtagat tttgataatg acaaacaaag tattactgat atcggagata tctatgaata   729240
tctgttatca aaattgtcga ccgcaggtaa aaatggacag ttccgtacac ctcgtcacat   729300
catcgatatg atggttgagt tgatgcaacc gactatcaaa gatatcatct cagatcccgc   729360
tatgggttct gctggcttct tagtatctgc tagccgttac ttaaagcgta agaaagatga   729420
atgggaaacc aatacagata atatcaatca ttttcataat cagatgtttc atggaaatga   729480
tacggatacg actatgttga gacttggggc gatgaacatg atgctacatg gagtagaaaa   729540
tccacaaatc agttaccttg actcgctgtc tcaagataat gaagaagccg ataaatatac   729600
tttggtttta gcaaatcctc cttttaaggg ctcacttgac tacaattcaa cctctaatga   729660
ccttcttgca accgtaaaaa ccaaaaaaac agaattactc tttctttctc ttttcttgcg   729720
aactttaaaa ccaggtggac gagcagcagt tatcgtacct gatggtgtcc tttttggttc   729780
gtctaaagct cataaaggaa ttcgtcagga aattgtagag aatcataagc ttgatgctgt   729840
aatctcaatg cctagtggtg tgttcaagcc ttatgctgga gtttcaactg ccattctcat   729900
ctttacaaaa actggtaatg gtggtactga caaagtctgg ttttacgata tgaaagcgga   729960
tggtttaagt ttggatgata agcgacaacc gattagcgac aatgatattc cagatattat   730020
cgaacgcttt catcatcttg aaaaagaagc agaacgtcag agaacggatc aatctttctt   730080
tgttccagtt gctgagataa aggaaaatga ttatgatttg tctatcaata aatataaaga   730140
gattgagtat gaaaaagttg agtatgaacc aacagaagtc atattaaaga aaatcaatga   730200
tttagaaaaa gaaattcaag ctggcttggc tgaattggaa aaattactca agtagggagg   730260
tggctgtatg aaaaaagtga agttggggga agtcttatct ctaaaaaaag gcaagaaagc   730320
cactgtactt gctgaacaaa caactctaag ccaacgttat attcaaatag atgatttaag   730380
aaataataat aatttaaaat tcactgaaag tttaaatatg actgaagcac tcccagatga   730440
tattctgata gcatgggatg gagctaatgc aggaacagtt ggttatggat tatcgggagc   730500
tgttggtagt acaattacgg tcttaaaaaa gaatgagcga tacaaagaaa aaattatatc   730560
agattacttg ggagtctttt tggaaagtaa atcgcagtat ttacgagatc attcaacagg   730620
tgcaacaatt cctcatttaa acaagaatat attacttgat ttacaattag aattgctagg   730680
tatcgaagaa caagagaaca ttatctgtat tcttaatacg attaaaaggc ttattactaa   730740
aagaaaattt cagttagatg aactaaactt gctcgtcaaa tcccgattta acgagatgtt   730800
tggggaaaat aaaatatttg aaagcattga taacttattt gatattatag atggtgatag   730860
gggcaaaaat tatcctaaat cagatgagtt gtttagtgag gagtactgtt tatttttaaa   730920
tacaaagaat gttactaaaa acggattttc attcgataca aagcaattta tcactaaaac   730980
aaaggataaa ttacttcgaa aaggcaaact tgagcgttat gatatagtct tgacaacaag   731040
aggtactgtt ggaaatgtag cgtactacga tgaattaata aaatataaac atttacgtat   731100
aaattcaggt atggtaatat tacgtcccaa gacaccaaat ctaaatcaga aatttattat   731160
ccatgtttta aggaataata attatagtcg agtgatatca ggaagtgctc agcctcagtt   731220
accaattaca aaattaaaaa aaatacttct ccccctcccc ccactagccc tccaaaatga   731280
gttcgcagac tttgtagtcc aggtcgacaa atcacaattg gcaatccaaa aatctctgga   731340
agaacttgaa actttgaaga aatctctgat gcaggagtat tttggctgat attctgccat   731400
tgtaattacg gtaatgattt gttataatac ttcaaaggag gaaatcagat ggtagtaaaa   731460
acaagaaaac aaggaaattc aatcaccatt acgattccaa gtgaatttaa tattccaagt   731520
ggtgttaaat acgaagcgaa attgttacca agtggtgaga ttatctttac tcctgaagaa   731580
ttggggcagc aggtttctta tgtatctgat gatgcctttg acttaaattt agataaaata   731640
tttgacgaat acgacgatgt tttcaaagct ttggtggaaa aatgacaatc tatttgacag   731700
aaaagcaaat tgaaaaaata aatgctttag caattcaacg gtattctcca aatgagaaaa   731760
ttcaaacagt tagtccttct gccttaaata tgattgtgaa cttaccagaa caatttgtct   731820
ttgggaagcc tctttatcca acaatttttg ataaagcaac gatactattt gtccaattga   731880
taaagaagca tgtttttgct aatgctaata aaagaactgc tttcttcgtt ttggtcaaat   731940
ttttacaatt aaacggctat cgtttttctg taacggtaga agaagcagta aaaatgtgtg   732000
taaccatcgc agtagaagct ttaactgatg aaaaaatgac aagctactcc aaatggattt   732060
ctgaacattc tgttagagaa aaggtcaaaa agtaacctag tatgctggat ttgaatgagc   732120
acaagaaaat aaatgaacag acaatattag aattctgtaa tgcagaaact gatattgtct   732180
ctttttattg atgaataaga aagtgagaaa ttatggaatc aaaagttaca attatcatgc   732240
aagaaatgtt acctctttta aataatgaac aattactagc gttgagagag agtttagaac   732300
atcatctagt agacggaaaa aagcagcaga agtattcgaa taataacctg ttgcaactat   732360
ttattaccgc caagcaggta gagggctgta gctcaaaaac aattcgttat tatcagagga   732420
cgattgaaaa cttgtttaat gctattaaag agtctgtgac acaactcaca acagatgatt   732480
taaggagtta tttagcaaat taccagtctg aaaaggattg tagtaaggca aatttagaca   732540
atattaggcg tatattgtct tctttttttg cttggcttga gcaagaggaa tatatcatta   732600
aaaatcccat tcgacggata aagaaaatta agactgagca aaatgtgaag gaaacttata   732660
ctgatgaaca tttggaaatt atgcgtgata actgtgaaaa tttgagagat ttggcaataa   732720
tagacctact agcatcgaca ggtatgcgtg taggggagct tgtacagttg aatcgttcag   732780
atattgattt tgaaaacaga gagtgtgttg tctttggtaa aggaaagaag gagagaccag   732840
tatattttga cgctcgtacg aaaattcatt taagaaatta tcttaacgac agaaaagata   732900
gtcaccctgc tctttttgta acgctagttg gaaaagtcca gaggcttgga attgctggtg   732960
tagagattcg cttaagaaag ttaggagaca aactcggcat acaaaaggtt cacccacata   733020
agttcagaag aactttagcg actaaggcaa ttgataaagg tatgcctatc gaacaagtcc   733080
aaaaactgct aggtcatagc aagattgaca caaccttggc ctatgccatg gtcaatcaaa   733140
ataatgtcaa gcattcacac caaaaattca tctcttaaaa gcaaatcccg atttaacgag   733200
atgtttgggg aaaataaaat atttgaaagc attgataact tatttgatat tatagatggt   733260
gataggggca aaaattatcc taaatcagat gagttgttta gtgaggagta ctgtttattt   733320
ttaaatacaa agaatgttac taaaaacgga ttttcattcg atacaaagca atttatcact   733380
aaaacaaagg ataaattact tcgaaaaggc aaacttgagc gttatgatat agtcttgaca   733440
acaagaggta ctgttggaaa tgtagcgtac tacgatgaat taataaaata taaacattta   733500
cgtataaatt caggtatggt aatattacgt cccaagacac caaatctaaa tcagaaattt   733560
attatccatg ttttaaggaa taataattat agtcgagtga tatcaggaag tgctcagcct   733620
cagttaccaa ttacaaaatt aaaaaaaata cttctccccc tccccccact agccctccaa   733680
aatgagttcg cagactttgt agtccaggtc gacaaatcac aatttgcttg tgagatagct   733740
ataaaagtgt ggagaaatag cttgaaattt agtataatat agctaaacta tttgtttaaa   733800
gtgagaaaaa aatgggaaat tttagctttc ttttaaaaaa tgacgaatat gaatcttttt   733860
caaaaccttg cattgaagct gagaatatga ttgctacatc aactgtggct actgccttta   733920
tggcgcgtcg tgctttagag caggctgtcc attggatata tagtcacgat tcatatttag   733980
aagctcccta tcgtgctact ctatcttctt tagtatggga tgatgatttt agggatatcg   734040
tagattctga actccacaag cagatagttc tgttgattcg gtggggaaac catgctgctc   734100
atggtggtga aattaaggaa cgagaagcga ttttagcttt gcatcatttg tatcagtttg   734160
ttaattttat cgattattgt tacagcaatg agtttgtgga gcgttatttt gatgagaagt   734220
gcttaccact ttcagcaaac atcaaatacc gagaaactcc acaatctatg ataaagttac   734280
aagacagttt accagaactg cctgattttc atgaacagat ggctgctcag tccgtagaag   734340
ttcaagagac ttatactgaa aaacgtgaga ctgcagcgca acggcaagat gtgcctttcc   734400
atattgatca attatctgag gcagagacaa gaaagctctt tattgatatc gatctccgtt   734460
tagcaggatg gatatttgaa gaaaactgtc gtgttgagat agccgttgat ggtctcaagc   734520
acggttcagg aattggttac tgtgactatg tactttatgg taaaaatggg aaaattttag   734580
cgattgtgga ggctaaaaaa gcctctgtca atccagaagt aggggaagta caggtcaaag   734640
aatatgctga agctttggag aaacatatcg gctatcagcc aatttgcttt attacaaatg   734700
ggttgaagca ctatatactt gatggtccga accgccgcca gattgcaggc ttttactctc   734760
aagaagaatt gcaattagtg atggatagac gtcatcttca aaaaccgctt gaggatattt   734820
ctagtaaaat tagggacgat atttccgggc gtcactacca aaaacatgcc attgcaagcg   734880
tttgtgaagc tttctctgat catcgtagac aggcactttt ggttatggca actggggcgg   734940
ggaaaactcg tacagcagtt tctctagttg atatcttatc acgtcataac tgggtaaaaa   735000
acgttctctt cttagccgat agaacttcct tggttaagca agcatatgat tcgtttagaa   735060
aattactccc agatctttcc gtttgtaact tcttagaaga taaagaagga gctcaatcaa   735120
gtcgcatggt cttttcaact tatccgacca tgattggagc gattagtggt caagaagaag   735180
taaatcaacg ccctttcact gttgggcatt ttgaccttat cataattgac gaatctcacc   735240
gttctattta tcagaaatac aagtccattt ttgattattt tgatgcaaga attgtaggct   735300
taacagctac tccgcgtcaa gatttagata aaaacaccta tggattcttt aatttggaga   735360
atggggttcc aacatatgca tatgatttgg aagaggctgt taaagacgga tatttagtag   735420
cctatcattc tatcgaaacc aaactgaaac tacctacgga tggtctacat tatgatgatt   735480
tgtccgaaga agaaaaggaa cattttgata gcaaatttga agacaatagc tgtgaaaaag   735540
atattgatgg gagtgtattt aattccttta ttttcaataa aagtacagta gaaattgttt   735600
taaatgaact catgacaaga ggaattcaga cagcctcggg tgatgaaatt ggtaaaacta   735660
ttatttttgc taaaaatcat gatcatgcgg aatatatcag aggtattttt aacaaccgct   735720
atcctgaaaa agggagcgac tatgctcagg tgattgatta tagtattaag cattatcaga   735780
ccttgattga tgattttaaa attaaggaga agtatcctca aattgcgatt tctgtcgata   735840
tgttagatac aggtattgat gtaccagagg ttgttaattt agtcttcttc aagaaagtac   735900
gctctaaaac taagttttgg cagatgattg gtcgaggaac ccgtctatgt aaagatttat   735960
ttggacctga gcaggataag gaaaacttct tggtatttga ttatggggac aattttgatt   736020
attttcgtgc agatccaaga gatggagagg gtcgtcacat tgtttcgctg actcagcgtt   736080
tatttaatat caaagtggac ttgattcgag aacttcaggg actccaatac caagaagatc   736140
agtttgcgag agcataccgt cagcagcttg tctcggaact tcaaggtcgt atagagagct   736200
taaatgagtt ggacttcagg gttcgtatgg ttttagatac agtttatagc tataggaaat   736260
tggaaagttg gcagaatcta actgctgtta caagtgaaac cattcaaaaa aatctctctc   736320
cgcttttatt tgatgaagat aaagaagatg agatggcgag gagatttgat ttgtggttgc   736380
ttcatattca gttggggcaa ctgacagcta aatcttccac tgttcatatt tcccaagtga   736440
tgaagacggc tagagctctt tctgctattg gcaatatccc gcaggttttt gagcaggctg   736500
aaattatcag gaaagtacag gagcctgaat tttggaaaga agttaacttg tctgatttgg   736560
aaaaaattcg tcttgctatt cgagatttat tacagttttt ggataaaaca gaccgtaaac   736620
cctactatgt taactttgaa gatcgtatac tctccactgt tcacgagacc acagcatttt   736680
tgcaggtcaa cgatcttcgg tcttacaatg aaaaagttga gcattatttg aaaactcatc   736740
tggatgagga gtccatttct aagctatacc ataataaaaa gttgacatct gatgatatgc   736800
ttgcacttga aaaattgctt tgggaaaaat taggtagtaa agcagactac caaagtcatt   736860
atgaaaataa ggcaattccg agattggttc gtgagattat tggcttagat agagagtctg   736920
ccaatcgtat tttttctaaa tttttgtcgg atgagaatct taatgccagg cagatttcat   736980
ttgtaaaatt gattgtagac tacattgtag aaaatggttt tttagagacg aaagtgttaa   737040
cgcaagagcc gtttaaatct tatggttctg ttcaactact cttccaacac caactaccag   737100
tacttcgtaa tattgttcaa atcattgaac ttatcaataa tcgagctgga gaagcggctt   737160
aaattctaaa gtgattgcca tgctgagact catttaaaat taaaaagagt agaaatttat   737220
gctatatatg agaagtttta ttaggaagaa tgtcatcgtt ttcctagaat acagtatcag   737280
ttgttaagtg gttgataaat ttcaaagtag atacttgtac cacgatgttt gttgatcgag   737340
ttattaacaa aagagctact ttgattttaa agaaatagaa aacaaaaagc cgagcaagaa   737400
ttcaattgca ggagaaaatg aaataatact caatgaaaat caaagagcaa actaggaaac   737460
tagctgcagg ctgctcaaaa cactgttttg aggttgcaga tggaagctga cgcggattga   737520
agagattttc gaagagtata aatcttccta ggataaagca aaacgcatag tatcaagggt   737580
tttcaacact tgatactatg cgttttctga tgttaaagac tttctaccag gttttttaaa   737640
agcataattg ttagttgtag tcatttatta ttcttcaaag aaaaatggtg gggcgaattt   737700
tttcagttct tcaaagcact tttgagcagt atctgcatct tcacagatga taagacagac   737760
atcattacca caaagggtag cgatagcgtc agggaagctc aaagtatcaa tgatagaacc   737820
aaaggattga gccagtccag gaagggtttt tagtaggact tggtgttgaa ctgggcgcat   737880
ccagacaagg gcgtcttcca tgtagagttc gagacgtttt tcccattttg agatggaacc   737940
attgttaaga acataataag cgctatcttc ttcgcggact tttgataggt tcatattttt   738000
gatgtcgcgt gagagggttg cctgggttac ttgaatgtcg ttctcagcaa gaagggcttg   738060
caactcagcc tgtgtatgaa tcttgttttt tgtgataaga gcgcgtataa gttggtggcg   738120
gtgttctgat ttattcataa taatgtaact ccttttagca aggtaaggta agcatggact   738180
gagcgaggtc gacagtcaag tggtagtctg tattgtcacg gatggtgatt tcaaagtcag   738240
tagtatagag gactaaacgg agagtgtctc cttcttttag cttgtaaata gttggctgca   738300
gttcaaattg aacgtccatc cattcatctg cagtaatatc ctctactaac agtaaatcat   738360
ttctattttg taaattaagg taaccttttg tcacgactcg ttgtgcctct ggtctaaatg   738420
gcaattcaca gagattttcc aacatgtgat agcgaccgtt gtcaatggtt ctagcactta   738480
aaatagctgg ataaggttgt aggtatttct tttgcccaaa ttctagcagt tgggcagata   738540
agagcccctt gtttgtactg gatttgatac gaagattgag ctgagcgcga ccgtttaggt   738600
ggagatcttt agtcacagga aggttaatag taatctgatt ggctttccct tgatagagct   738660
ctgtattgaa ggtttggtat gtcttaccat agcgctcaaa atccttatct gggtactggt   738720
tttgaatagc ttgctcttct tgaccaagtg agaaggtttc acagttttct tgcccaccga   738780
agttatcaag tgataaccaa gtctgtggag ctgtattgtc ctgccagata acagtaggaa   738840
gttgaaagtc tgtttcctgt cctagtaatt tcttggtcaa taaggcattt atggactcac   738900
ggaagtcaat tgattgccaa ttgttcatgt aaacatgggc accattatgg aaaaagagat   738960
gcttgtgtat atgagtagga agagcatgga acatctggta aacatgaagt ggtttgacat   739020
tccaatcctg agaaccatga gtaaagacaa cctctgcctt tactttatgg gcattgagca   739080
gataattgcg gtcatgccaa aactgattgt agtccccagt ttttcggtct agctgagctt   739140
tcactttttc taagtcagct tggtgagctt cattgccacg gatatagtcg ccagctaaga   739200
gattacgaga ataggttaac tcagcaaggg agtcaaagtc ctcacctgga taaccacctg   739260
ggctagtcac cagaccgttt tcacggtagt agttgtacca tgatgaaatt cctgcctcgg   739320
caatgataac ttctaaacca tcgactcctg tagtcgcaag accattggac atggtaccta   739380
gataggaaag tcctgttgta gcaacttttc cgtttgacca atcagccttg acttgacgct   739440
ggcgcgtgtg atcagtaaag gcacggcaac gaccgttaag ccaatcgatg acatttttat   739500
aagcctcgat ttgctggtag tctccattag tcatgaaacc tgtcgagtct ttggtaccaa   739560
cacctgagac atagagattg gcaaagcctc tcggaaggaa gtagtcgttt agtgtatagc   739620
tagagttgat gtgagttagc ttttcctcag cctctgctat aagctcagct ttaccttggg   739680
gttggacgag atttagttga ggtttctcta gctcaatctt gtgaggaagc ttaacctcaa   739740
gctcgccctc catcttgtag agagccttgt cactagcctt gtcattggtt ccctgatgat   739800
aagggctggc tgtcatgatg gcagggattt ttccatcaaa acgagggcga ataatgctaa   739860
cctttactag gtctgatagc cctttttggt cagtatcgac acgagactca acgtaaacga   739920
cttcacgaat gacatcctgg ttagaaaaag tagccaaact cttgccgtta aagtagtggt   739980
agtcattatc ctccggaata agaccatcac taacaagttg gtcgataaga gtatttcctt   740040
ttttggtgcg agtattgagt aactgataga gattttcaat caagtcacca tatataatgg   740100
gaaatccagt ttctttacga aaaacgtcac tatcttcgaa gtcaaccaaa taagaaaagc   740160
ctaaaagttg aaaagcaaca gtataaaaaa tatctgctgt cagttcatct tctgattgaa   740220
aaaatgtcag caggtctgtt tttttatcag ctgctaggat agaaagtggg tagttggtgt   740280
cttgataagt gaaaaagaaa cgacgtaaaa aggtttcaag tgagtctttg tgattggctg   740340
tattttgtaa atcaaagcca cattttttta gttcagataa gacattttct tttggaaaat   740400
tgatataact atattgatta aaacgcatag aacctccata tagaatgaca gttaaggtta   740460
ttatatcaaa aaaaaagcag aaagggaatt gttaacttca aaaggaaata atccaataaa   740520
aatgaataaa gtactaaatt caatatagag aacagagtaa caataagaat aaatagatag   740580
ggtataaaag ttctaggaga tttatattat atgctttcta tttttatata caatatagta   740640
taaatataaa aatgatgaca aaaatacaaa tgaatagaaa ataaattagt aagctgatga   740700
aatttttctc aagagaagcc atttataggt gaaaatggta taatatagtg agaaggatag   740760
aggagaagtg taaattgatc gcacaactag atacaaaaac agtctatagt tttatggaaa   740820
gcgtcatttc gatcgaaaag tatgtgagag cagctaaaga atacggctac actcatttgg   740880
ctatgatgga tattgacaat ctttatggcg ctttcgactt tctagagatt acaaaaaaat   740940
acggcattca tcctttgcta gggcttgaaa tgacagtgtt tgtagatgat cagggagtga   741000
atttgcgctt tttagctcta tctagtgtgg gctatcagca gttgatgaag ctttcgacag   741060
ccaagatgca gggggagaaa acttggtcag tcctgtccca gtacctggag gatatcgcgg   741120
tcattgtgcc ttattttgat agagttgagt cgttagaact aggctgtgat tactatatag   741180
gggtttatcc agaaacacta gcaagcgaat ttcatcatcc tatcttacct ctttatcggg   741240
tcaacgcttt tgaaagcagg gatagagaag ttcttcaagt tttaacagcg attaaagaaa   741300
atctaccgct cagagaagtt cccttgcgtt cgagacaaga tgtctttata tcagcaagtt   741360
ctttagagaa actattccaa gagcgttttc cgcaagcttt ggacaattta gaaaagctta   741420
tttcaggcat ttcttacgac ttggatacta gtctgaaact gcctcgtttt aatccagcta   741480
gaccagcagt agaggagttg agagagcgtg ctgaactggg gcttgttcag aaggggttga   741540
ctagtaaaga atatcaagat agactagacc aagaattgtc tgttattcat gatatgggct   741600
ttgatgatta tttcttggtt gtttgggatt tgttgcgttt tggacaatcg aatggctatt   741660
atatgggaat gggaaggggt tctgcagtag gcagtttggt ttcttatgcc ttagacatca   741720
cggggattga cccagtagag aaaaatctga tttttgaacg ctttcttaat cgtgaacgct   741780
ataccatgcc tgatattgat attgatatcc cagatattta tcgtccagat tttatcagat   741840
atgttggtaa taaatatggt agtaaacatg cggcacaaat cgttactttt tcaacctttg   741900
gagccaagca agctcttcga gatgtcttga aacgctttgg tgtgccagag tatgaattat   741960
ctgcaattac taagaaaatc agttttcgtg acaatcttaa gtcggcctat gagggaaatc   742020
tccagtttcg tcagcaaatc aatagtaagt tagaatacca aaaagctttt gagattgctt   742080
gcaagataga gggctatcca aggcaaacct ctgtccatgc ggctggtgtt gtaattagtg   742140
accaagattt aaccaactac attcctctaa agtatggtga tgaaattcca ctgactcagt   742200
atgatgctca tggagttgag gctagcggac ttttgaagat ggactttctg ggactacgaa   742260
atttgacctt tgtccagaag atgcaagagt tgcttgctga aacagaaggt attcatctga   742320
aaattgaaga aatcgattta gaagacaaag aaacgttagc tttatttgcc tctggtaata   742380
caaaaggtat ctttcaattt gagcaaccag gtgccattcg tctgcttaag cgtgtgcaac   742440
cagtctgttt tgaagatgtc gtcgcgacta cttctctaaa tcgaccgggt gctagtgact   742500
atatcaataa ttttgtggca agaaagcatg ggcaggaaga agtgactgtt ctggatccag   742560
tactggagga tattttggct ccaacctacg gcataatgct ctatcaggag caggttatgc   742620
aggttgccca gcgacttgcc ggatttagtc ttgggaaagc cgatattttg cgtcgggcta   742680
tggggaaaaa ggatgcctct gccatgcatg agatgagggc ttcctttatt caaggttcat   742740
tagaagctgg tcatactgtg gaaaaagcag agcaggtctt tgatgttatg gagaagtttg   742800
caggttatgg ttttaacagg tcacacgcct atgcctactc agccttggcc ttccagttgg   742860
cttatttcaa aacgcattat ccagccattt tttatcaggt catgttaaat tcttccaaca   742920
gtgattactt aatagatgca cttgaagcag gttttgaagt agcctctcta tccatcaaca   742980
ccattcccta tcacgataaa attgccaaca aggccatcta tctaggtttg aaatccatta   743040
aaggagtcag taatgattta gctctctgga ttattgaaaa tagaccttat tctaacattg   743100
aagattttat agctaaatta cctgagaatt atctgaaact tcctctgcta gaacctttgg   743160
taaaagttgg tcttttcgat tcatttgaaa aaaatcgtca aaaagtattt aataacttag   743220
ctaatctatt tgaatttgtg aaagagttgg gaagtttgtt tggagatgct atttatagtt   743280
ggcaggaatc ggaagattgg acggaacaag aaaaatttta tatggaacaa gagcttttag   743340
ggataggtgt cagcaaacat ccactacaag ctattgcaag taaggctatt tacccgatta   743400
ccccaatcgg aaatttgtca gaaaatagct atgctattat cttggttgaa gttcagaaaa   743460
taaaagtgat tcgtaccaaa aagggtgaaa atatggcctt cttacaggca gatgatagta   743520
agaaaaaatt ggatgtcact ctcttttcag acttatatcg tcaggttgga caggaaataa   743580
aagagggagc cttctactat gtaaaaggaa aaatacaatc acgtgatggc cgtctgcaaa   743640
tgattgcaca agaaataaga gaagcagttg ctgaacgctt ttggatacag gtgaaaaatc   743700
atgaatcgga tcaagaaatt tcacgcattt tagaacaatt taaaggccca atcccagtca   743760
tcatccggta tgaagaggaa cagaaaacca tcgtttctcc ccatcatttt gtagctaaat   743820
ccaatgaatt agaggagaaa ttgaatgaaa tcgttatgaa aacgatttat cgctaaaaat   743880
acggaaaata gaagaatttt caacgtaaat gtggtataat cagtaagaat gttaaaagaa   743940
aaaggagcat aaccaatatg aaacgtattg ctgttttgac tagtggtgga gacgcccctg   744000
gtatgaacgc tgccatccgt gcagttgttc gtcaagcaat ttcagaagga atggaagttt   744060
ttggtatcta tgacggatat gctggtatgg ttgccggtga aattcatccc ctagatgcag   744120
cttcagtagg ggacatcatt tctcgtggtg gtactttcct tcactcagct cgttacccag   744180
agttcgctca acttgaaggg caacttaaag ggattgagca attgaaaaaa cacggaattg   744240
aaggtgtagt tgttatcggt ggtgacggat cttaccacgg cgctatgcgt ttgactgaac   744300
atggcttccc agctattggt cttccaggta caatcgataa cgatatcgtt ggtactgact   744360
ttacaatcgg ttttgacaca gcggttacta ctgccatgga cgctatcgat aagattcgtg   744420
atacatcatc aagtcaccgt cgtacttttg taatcgaagt tatgggacgt aacgctggtg   744480
atatcgctct ttgggctggt attgcaactg gtgctgatga aatcatcatc cctgaagcag   744540
gcttcaagat ggaagatatc gtagcaagca tcaaagctgg ttatgaatgt ggtaaaaaac   744600
acaatattat cgtcttagct gaaggtgtga tgtcagcggc tgaatttggt caaaaactta   744660
aagaagctgg agatacaagc gaccttcgtg taacagaact tggacatatt caacgtggtg   744720
gttctccaac tgcgcgtgac cgtgttttgg cgtcacgtat gggtgcacat gctgttaaac   744780
ttcttaaaga aggtatcggt ggtgttgcgg ttggtattcg taacgaaaaa atggttgaaa   744840
atccaattct tggtactgca gaagaagggg cattgtttag ccttactgca gaaggtaaga   744900
ttgtggttaa caacccacac aaagccgata ttgagctatc tagcttgaat aagagcttgt   744960
cataatttac aatttagtta ataagaccaa aaaggtcata tatataaagg agtcacaaaa   745020
atcatgaaca aacgtgtaaa aatcgttgca actttgggtc ctgcggtaga aatccgtggt   745080
ggtaaaaaat tcggtgagga cggatactgg ggtgaaaaac ttgatgttga agcttcagct   745140
aaaaacattg ctaaattgat tgaagctggt gctaacacat tccgattcaa cttctcacac   745200
ggcgaccacc aagaacaagg tgagcgtatg gcaactgtta aacttgcgga aaaaattgca   745260
ggtaaaaaag ttggtttcct tcttgataca aaaggacctg aaatccgtac agaattgttc   745320
gaaggtgaag ctaaagaata ttcatacaaa actggtgaaa aaattcgtgt tgcaactaaa   745380
caaggaatca aatcaactcg tgaagtgatt gcgttgaacg ttgctggtgc tcttgatatc   745440
tatgatgatg ttgaagttgg tcgtcaagtt ttggttgacg atggtaaact tggtcttcgt   745500
gtggttgcta aagatgatgc aactcgtgaa tttgaagttg aagttgaaaa cgatggtatc   745560
atcgctaaac aaaaaggtgt gaacatccct aacactaaaa ttcctttccc agctcttgct   745620
gaacgcgata acgacgatat ccgtttcggt cttgaacaag gtatcaactt catcgcaatt   745680
tcattcgtac gtactgcaaa agatgtgaac gaagttcgtg caatctgtga agaaactgga   745740
aacggacatg ttcaattgtt cgctaaaatc gaaaaccaac aaggtatcga taacttagat   745800
gaaatcatcg aagcagctga tggtattatg attgctcgtg gtgatatggg tatcgaagta   745860
ccgttcgaaa tggttccagt ttatcaaaaa atgattatca agaaagtcaa tgctgcaggt   745920
aaagttgtta tcactgcaac aaacatgctt gaaacaatga ctgaaaaacc acgtgcaact   745980
cgttcagaag tatcagatgt attcaacgct gttatcgacg gaactgacgc tacaatgttg   746040
tcaggcgagt ctgcaaacgg taaataccca ctcgagtcag taactacaat ggctacaatc   746100
gacaagaacg ctcaagctct tcttaatgaa tacggacgtc ttgattcaga ttcatttgag   746160
cgtaactcta agacagaagt aatggcttct gctgttaaag atgctactag ctcaatggat   746220
atcaaattgg ttgtaactct tactaagaca ggtcatactg cacgtttgat ttctaaatac   746280
cgtccaaatg ctgacatctt agcattgaca tttgacgaat tgacagaacg tggcttgatg   746340
ttgaactggg gtgttatccc aatgttgaca gatgctccat cttcaactga cgatatgttc   746400
gaaatcgctg aacgtaaagc ggtagaagca ggtctcgttg agtcaggcga tgatatcgtt   746460
atcgttgctg gtgtgccagt aggagaagct gttcgcacaa acacaatgcg tatccgcaca   746520
gtacgttaag aaaaatataa aaacctatca tatccagctt tagagcttgt gtgataggct   746580
ttttgtatag agggtaagaa ataggcaaaa ctttcataat ggattgatac tcttcgaaaa   746640
tctcttcaaa ccacgtcagc gtcgccttac cgtatatatg ttactgactt cgtcagttct   746700
atctacaacc tcaaagcagt gctttgagca acctgcggct agcttcctag tttgctcttt   746760
gattttcatt gagtatgaaa taagatatgc acaaattgat tagaaagtca aatgaatttc   746820
tacaaatgtt ttagcaatcg taatgtactt gtctagattc gatctgatat attttcgatt   746880
taatgatatg gtatttaaaa cctccaaagt agcttactcc attcttttac ttacgtgagt   746940
gtagatgtta tttactgttt tagcgttttt gtgttccact ctaaccatta tagcattctt   747000
ctcagctagt gtactaagga gtgtgtgcct gaaaatatgg gaactaaggg gctggtttat   747060
cggtttctct agtttagtat ttgccttttg caaagtgatc ttaaatgcct ttctctaaat   747120
ttacatatca ctattgttta acaaaatcta atctatttta ggtcacttat tctttttttg   747180
aaatgtagaa tgaacttttt caaagttttt cgaatctttt aaaatctgtt tgctttatat   747240
cgccattctc cccccttttt taattctccc tatatagcct gacagctttc ccgatggtac   747300
gaatatggtt gctttcgtct aggtggatgt cggggtattc gggattgagt ttttttgagg   747360
cagccttggc ggagtttctt gacatagtta gtgccgtcta cttggaagat gccgatggta   747420
ttatagtcaa tctgtggggt attcttgata aataggtagt cgctgtttct tatctttggc   747480
tccatggact tgctgacgac ataagcgatt gggtcgtagt cgtctgggat aatggaaact   747540
ccatatctaa atcgttgtcc tgcatcgagc ggctacctgc agagataaac tacctaacac   747600
gagagtaagt agtctgtctg tagtcgtcca gtctgatgat ttttacgata cttcgttttt   747660
ctgatcatac agttgcctct cggcataggt cagaacttta ccttgtctgg gtggttcccg   747720
ttggtcgtag atagattgga tatcgctagg agaatccttt tgaactggag gaaagagggc   747780
atcgatcaag ctactgaata ctttaactaa gtcaaatata gtatttttct tagtagacct   747840
aacccttttt tcataatttc taatggtgtt tttacttata cctatcttag tacccaattc   747900
ttattgagtc caaccattac tagtctatat tgttttatag ttgattgagt ttggaatagt   747960
acgctgtagc tgctaaaaca tttctagaaa ttaatttgac tttcctaata gagttgttca   748020
tatcttattt caatctatta tgtttttcac ctctaacaat cgcaatctct tctttatcca   748080
tgaatgaaat cgctttctat ttttgtaagt aaagcataac acgaaatcca cgaaaatgaa   748140
aacctttgtt gtgttttcgt aaaaaatttg ttgacagagc acgaaacgcc tactataatt   748200
aaatcaagct taaggaaata acaaaaaaac aaatcggagg gaaagacgat gaacacatta   748260
aatgagaaag taatcaatat ctgtaaagca atagttaaag aaactttaat ccaagacatt   748320
taggagaaag aaatgaagaa atcaagaaaa ttagccacat taggaatctg ttcagccttg   748380
tttttaggct tggctgcttg tcaacaacaa catgctactt ctgaggggac gaatcaaagg   748440
caaagcagtt cagcgaaagt tccatggaaa gcttcataca ccaacctaaa caaccaggta   748500
agtacagaag aggtcaaatc tctcttatca gctcacttgg atccaaatag tgttgatgca   748560
ttttttaatc tcgttaatga ctataatacc attgtcggct caactggctt atcaggagat   748620
ttcacttcct ttactcacac cgaatacgat gttgagaaaa tcagtcatct ctggaatcaa   748680
aagaagggcg attttgttgg gaccaactgc cgtatcaata gttattgtct tttgaaaaat   748740
tcagtcacca ttccaaagct tgaaaagaat gaccagttgc ttttcctaga taatgatgcg   748800
attgataaag gaaaggtctt tgattcacaa gataaggaag agtttgatat tctattttcg   748860
agagttccaa ctgagtcaac tacagatgtc aaggttcacg ctgaaaagat ggaagcattc   748920
ttctcacaat ttcaattcaa tgaaaaagct cgaatgctgt ctgtagtctt gcacgacaat   748980
ttggatggcg agtatctgtt tgtaggccac gttggggtct tagtacctgc tgatgacggt   749040
ttcttatttg tagagaaatt gactttcgaa gagccctacc aagcgattaa atttgctagt   749100
aaggaagatt gctacaagta tttgggcacc aagtatgcgg attatacagg cgagggactg   749160
gctaagcctt ttatcatgga taatgataag tgggttaaac tttaatagtg ttatgatatg   749220
acagtaatct taggattttt atttctattt ttgataagtt ggtgggttat ttcaatcgtt   749280
aatagccaga aaccacgcaa aaatgaaaca tttattggct atgtccaaag atacgatatt   749340
gatgggaatg gctatcaatc attaccgtgt cctcagaact gagaggagtt cttgaaatcg   749400
taacaccact ttgaacaaga gttacttaaa cccattggct ccgacggatt aagttgcttt   749460
cgtgaatacc aaaatcagcc gcaatttctt cataagtgcg gtattctcgc acatattgaa   749520
gagtggccat aagaaggtct tctaggctta atttaggttt tcgtccacct tttgcgtgtt   749580
taagttgata agctgttttt aatacagcta atatctcttc aaaagtcgtg cgctgaacac   749640
caacaagacg tttaaatcgt gcatcagtta gttgtttact tgcttcataa ttcatagaac   749700
tactatacca tattttgttt cgcaggaagt ctaatgctaa aatcttatca gtgagaagat   749760
ttcttaaagt ttattctttg tagtttcatc tgtattagta cataatttaa cttagagaaa   749820
ataggaggac taatcgaatg gaattaaaag attttacaga aaaagaacag gaaatgatta   749880
agaaaaggct tacaatgtct aatattagtg acaaagaaac tactgagaag attctggcgc   749940
tagtcccaca agacttgatt aagcgaatcc cgttttttgt cagaaaacat gctacaacac   750000
gtacgattaa acgcatttca attgaatacc ctgaactcta cgctgtagct caaacaagtg   750060
gtgagattcc agaaaaaaaa cgcgaagaat tgcgtcagat tatcacaact atctttgaac   750120
aaaagatgaa taagcatagt attaagtaga gaatgaaaaa atattttatt ggcggtttgg   750180
gaagcaatgc ctatcatagc aaggattttc ttcaagaact agattcgcag gtctattttc   750240
taaatccata tgaaaagcat cttcgagatg aaacagaatt gaaatcatgg tttaaaaatg   750300
aaattgtaga ggaagaatct atctgtctga taggccattc tcttggagga gatttagctc   750360
gttatttcgc atcggaattt gaagaagtaa agaaactgat tcttttggat ggtggctatc   750420
tagatttaga taagatttta cctttggata cagagttaga ggaaactaaa aattatatca   750480
aatctcaaat tgtttcggac ttagatgttc ttacttctaa agaaaaatct gaagcaaagc   750540
attggtcaga aaatatggag aaagctgtaa gacagtctta tcactggaat gttgagtata   750600
atagatatga gttggctata aattatgaaa atatagaagc gatactccgc tacggagaaa   750660
aatacaagct tttaagagag aagtgggaga taccttgttt attagtcctc gctatcctaa   750720
tgaagctaca tggagagagg aagccctaaa agaattgcca gactattttg atactatttt   750780
tttagaaaac tttggccatg agctttatac tcaagcacct aaagaaatcg ctagtctaat   750840
gaatgagtgg ctcgcttatt ttctatgagc tacttgtatt gctgggaatg gtataagatg   750900
aaaatctaca agtcactaat tttcatataa caaaaaacga acaggctctt tttctgttat   750960
tcagaagaga acttgttcgt ttttatcttg attttcttaa aaagctctat atacataggg   751020
attttctggt ttatcgactt tggtaaagct gtcgatttcc aaggttggaa ggttttgttt   751080
gagttcttta tggtagtgat tgaccagttt tcctttggct gttatccaag tgttgttttc   751140
atactgccgg gtattgccct tggtcagcaa tccatagaca ccagaatctg cgatacagtg   751200
gataatgccg aatcggaaca gaaattgact attggcatga ctggggtcgt tatagacaaa   751260
gcctgtaaac tggattgtct tgccctcaaa ctcatctgga tagtcgtaga tagcctccat   751320
gacttccata tagttttcat tagtgatctg aatactatct tgggataagt atttatccgc   751380
cgccgttcgc atttcctttt cataggctga ttttgaaaaa taagaactgg tatctggttt   751440
caaatattgg cttgtcgtcc cttcgcttgt ctgaatggct agatccgttc cttccgatag   751500
ggggaaatga taacctttag cagaaacagt ctgagaatcc aagctaacag ttgggaaagt   751560
taagccgatg acaagtggaa tagccagaag agaaatactc gttatcttgg ctaatcggct   751620
gttcagatga ctgtgggttt tgacttgctt catccagata tacaattgaa cgatagccaa   751680
gataaaagaa agcaccatgg agatataggc cagataggaa tagtgcatgt tgatgtactg   751740
gtttagtttg cccgacagat ggaggtaaat agtcagttca aaatagccag ctaaaactaa   751800
aaatcgaatc ataggataac tccaatcaag agagaataga ctaagacgac aagagttaca   751860
attgttatga agtgactgat aaatcgtgct ttcaagtaat ttttcatcat gagaatattt   751920
ttgatatcca gcattggacc aatgacgaga aaggccagaa ctggtgccaa accgaaactc   751980
gagagaagag aagcacctat aaaggcatcc gcctcactac agagcgaaag aagaaaggct   752040
aaaatcatca agagcaggat ggcaaaaaga ggggtcgcac tgatagaggt cagaatccga   752100
gtcggaacgt agacctgtat tatagaagca aagaggcagc caaataccaa ataacgcccc   752160
gtatcaaaaa attcatcaat ggcctgcaca aagacttgaa aaactttttt tgcagaactc   752220
aagtaagaaa aatcatgctc atgacaagcc agacgatttt ctttctgaat cggttcttgc   752280
cagaaaaatc ctagaaaaat tcctagtatt acagccacaa gaatggaacc cagagctcgt   752340
aatagggcga catggaagga gttgccaaag gcagaatagg tcgcaaaaag aacaatggga   752400
ttgataacag gtgctgtcac aagaaaagga acggccgtgt aacttggaac ctttttttcc   752460
agaaaacgat tgatgatggg gacgattcca cattcacaag aagggaaaag tataccgaca   752520
aaggtcccaa aaaagattct cccccaacga tttcgaggga gaaaatgata aaccttgtca   752580
ggtgtgatat aaacttcaat cagccctgag acaatgcttc ctatcagaac gaagggaagg   752640
gcttcaatga taatggagag aaaaatggct ccagtttgaa gtacactaga tgggagttgt   752700
tgaaaagcag tcatctagtt tttcttttct gctttgactt ttttctcttt gtcatcaggg   752760
aaagtaactt gtttcaaatc agggagttta gcaaactctt caaacatctt gtccaagtcg   752820
tctcgttttg taaatttgac agccataggt gtacctcgat tctagattct acctctatta   752880
tactattatt ttgcggaaaa gggaaaagtt aaaatttcaa attgagtagc taagagataa   752940
tatagcttga tattacctga tatatatcat aattgtgcta taattaaata aaaagaaaat   753000
cattatcaga aaattatggg aggtagtcaa actgacttac tcaattagtg ttgttttgtt   753060
acatcaagga gataaaaata gtttattaga gtctttgtca atagtggaga gacaaacatt   753120
aaaagatata gaagttatta ttgtaaatca atctacagag gagatagctt ccattagcca   753180
acagatgaat ctatcattta atattaagat tatagatgag aattcttttg ctgagttgtc   753240
tgatatgatt acaggagatt atattacgtt tctatcttca aatgattcat tatttgattg   753300
gacatttgaa aagatgtatc atgcgataaa attatccgat tctgatgttg ttcttggtca   753360
ttttgctgat ttggttgatg gagtatttta cttttatcct ttttgggggg ataattggtt   753420
gacagaaaat ttaacgaatg ttcaagtttt acaaaagatg gatgatacag atcatcgaat   753480
tagaaaacaa tatcgctcat tatttggaaa attattcaat agtaagcttt tacgaaaaat   753540
aaatcaattt gatataaaca accttatttg gagactttat attcactcta aaactgcaac   753600
ctatattaat ttcccgacat atatctataa acctgttata gatgctaaac ctctaaaaga   753660
ctcctacaaa atcatattag aaaattatga aaatagaatc aaagattgcg ccgtcttaga   753720
aaactatgat atagaaagag cgaaaaaaca atatattcaa gaattggcaa attttagtgc   753780
ttggttaaaa aatgacggtg aatatttaga ttctgatatt gtttatcata agttaatagc   753840
tgcagagaaa ggaattttcc cttttcttga gcttgataga ttagatttta cgattataag   753900
taataattgt gttggaggat taatttataa acagcttggt tttcaatata gaacaccttt   753960
tgttggttta tttattcttc ctgatgatta ttataaactt acaaagcatt ttcgttatta   754020
tatggaacaa gaacttgttt tcgaagagga acttatttca ccgagctgga ctcatgaagt   754080
ttatcctttg gggcacttag gagatataga tattcatttt ctacattatt ctagtattga   754140
agaagcacga actaagtggg aaaaaagaaa aaaacgcata aattggaata atctttattt   754200
taaatttgat aataaagatt cagctagtga agaaatttta aataagatgg ataatcttcc   754260
ttattctaat aaattaattt tagtcaatcg tccatataaa aatttgaaaa gtcaatgtgt   754320
tattccaggt caggaacatc ttccagaact ggctattatg tctgatccat taaatacttt   754380
tgatatcatg gcttggttaa aaaaaggtgg caatgctctt taagtgcaag ttattgcgct   754440
gtagcatata aatctatttc ctacatattt tttaaatgtt ctacgagtta atttgaaacg   754500
tttagcttgt ggtataatag atttatggat aaaaaatatg aaaaaatctc tcaggatttg   754560
ggagtgacgt taaagcaaat tgataccgtt ctaagtttga cagctgaagg ggcgactatt   754620
ccctttatcg cgcgttatcg caaggacatg actggtagtc tggatgaggt ggcgattaag   754680
gctattattg atttggataa aagtctgaca aatctcaatg accgtaagga agctgtctta   754740
gctaagattc aagaacaagg taagttgacc aaggaattgg aagaagctat cttagttgcc   754800
gaaaaattag cagacgttga agaactctat cttccttata aggaaaagcg tcgtaccaag   754860
gcaaccattg cccgtgaagc tggactcttt cctcttgctc gcttgatttt gcagaatata   754920
gttgacttag agaaagaagc tgaaaagttc gtctgtgaag gatttgcgac tggcaaggaa   754980
gccttgaccg gtgcagttga tattttggtc gaagccttat cggaagatgt gaccttgcgt   755040
tctatgactt atcaggaagt gctgagacac tctaaactta cttctcaagc caaggatgaa   755100
agtcttgatg aaaagcaggt ttttcagatt tattatgatt tttcagagac agttggaact   755160
atgcaaggct atcgtacctt ggctctcaat cgtggggaga aacttggtgt cttgaagatc   755220
ggttttgaac atgcgacgga ccgtattctt gccttctttg ctactcgttt caaggtgaaa   755280
aatgcttata ttgatgaagt tgttcagcaa tccgttaaga aaaaggtctt gcctgctatc   755340
gagcgtcgta ttcggacaga attaactgag aaagctgaag aaggagctat ccaacttttt   755400
tctgacaatc tgcgcaatct cctcttggtt gctccactga aagggcgcgt ggttcttgga   755460
tttgacccag cctttcgtac aggtgccaag ctagctgtcg tggatgcaac aggaaaaatg   755520
ctgacaactc aggttattta tcctgttaaa ccagcatcag ctcgtcaaat cgaagaagcc   755580
aagaaagatt tagcagattt aattggtcaa tacggtgtag agattattgc cattggaaat   755640
ggaacggcca gtcgtgaaag tgaagctttt gtagcggaag ttctgaaaga tttccctgaa   755700
gtcagctatg ttatcgttaa tgaaagtggt gcttctgtct attctgccag cgaacttgct   755760
cgtcaggagt ttccagactt gaccgttgaa aaacgctctg ccatttctat cgcccgtcgt   755820
ttgcaagatc ctcttgcgga attggtcaaa atcgatccta agtcaattgg tgtcggtcaa   755880
taccaacacg atgtcagtca gaagaaacta tctgagagtc tggactttgt tgtcgataca   755940
gtggttaacc aagttggtgt caatgtcaat acagctagcc cagctcttct ttcacacgta   756000
gctggactca acaaaactat ctctgaaaat attgtcaaat accgcgagga agaaggaaaa   756060
atcacttcac gcgcccaaat caagaaagtt cctcgtctgg gagccaaggc ctttgagcag   756120
gctgctggtt tccttcgtat ccctgaaagt agcaatatcc ttgataatac aggagttcac   756180
ccagagaatt acactgcagt taaggaactc ttcaaacgtt tagatattaa agacctaaac   756240
gaagaagccc aaagcaaact caagtcgctt tcagtcaagg aaatggcgca agagttagac   756300
cttggtccag aaactcttaa agatatcatt gcagatcttc tcaaaccagg tcgagatttc   756360
cgtgattcct ttgacgcacc tgtgcttcgc caagatgtcc tagatatcaa ggacttagtg   756420
gttggacaaa agctagaagg agtggtgcgt aacgttgttg atttcggtgc ttttgttgat   756480
atcggaattc atgaggacgg tctcatccat atttcccata tgagtcgcaa gtttatcaaa   756540
caccctagtc aagtggtggc agttggagat ttggtgagcg tttgggttaa gaaaattgat   756600
actgaacgtg aaaaagttaa tctgtctctc ctagctccaa atgaaactga ctgattacgt   756660
caagcaggtt tcactagaag acttcggcag accttttatc catcatgtcc agtggaatag   756720
gcgtctacgt tcgacaggtg ggcgattttt ccccaaagat gggcatttgg attttaatcc   756780
caaggtttat caggaactgg ggttggacgt ttttaggaaa attgtccgac atgaactctg   756840
tcattatcac ctctattttc aagggaaagg ctatcaacac aaggatcggg attttaagga   756900
actgttgaaa gcagtggatg gattacggtt tgtaccatcc ttgcccaata gtaactccaa   756960
gccaatcaag ctctatcgtt gccaatcctg ccagcaaagg tatcagcgta agcgtaggat   757020
tgatacccaa cgctatcgct gtggactttg tcgaggaaag ttgctattag taaatcagcc   757080
tgaggactga tgaaagccga gcctatccgt gatatactag tctaacctag cagaaagagg   757140
aaatatcatg aacagtaagt tttataaaat gagacgaaat cgcatgattt caggagtttt   757200
agcaggtctg tcagacaagt ggaactttga tgttaccctt gtacgttttc tgtttgccat   757260
ttttacagtc gcaaactttg gacttggggt gattatctat atcatcctag cttctatcat   757320
gccaaccaag gaagaaatcg aagcagaaat gtacggaaca ggcccacgta aacgcaaaga   757380
agctcaagcc attgacgata atgaaggctg gttttggtga ggttttacaa aagatttgga   757440
atacgcaaaa agctttaaat caatagtcta aactgcttga tttaaagctt ttttactttt   757500
atactcaata aaaatcaaag tgcaaactag gaagccagcc gcaggctgta atttagtcgg   757560
caatgtgaag ttgatatagt ttgcactttg atttttgaat agtattaata atatttcgcc   757620
agcttcatcc acaaactata gtggattgga actagaatag gacacctata cttctaaaac   757680
attgttagaa atcgatttga ctgtcctgat cgatttgtcc tgttcttatt tcattttact   757740
ataaaagcag taatttaaac gcagtttttt aatctatttt tgctgttgag acaatacatt   757800
tttggaaaaa tggtggatgc tgataacaac tgataaccag caaataacat aagcagtgcc   757860
ggtaaattct gtactgataa agtgtgtgtg ttcaactaag agctgaccga tgaatggaga   757920
gagcagatag agaagtccga tgagtatatg ttctttgtgt ttcattaaag cgcaccttct   757980
ttccttatag gttgaacgac ttgcaagtgt taaattgaat ggtatgttat ctaggtaagc   758040
ttactaaaat gttagttccc gcttcctcct tttcaaagta agccttttca cacttatatt   758100
ttacaacttt aaaaatagga aatcaaatca ttttctaagt aattttgctt atatttcacc   758160
caatcttaca aaaatgtaag attaaagtct cttttgtaag gttaggttat ggcaagcggt   758220
ctttttttga tgtaaactag actcataaag aacaaaggag taacatcatg aaacaaatct   758280
tacataagaa aactagaaaa ccaagtcaca aagaaattga gcgcgttcag ctgggatgca   758340
ctatgatgca agctacattt catttgatgg gatattaaga aaggagattt tcatgacact   758400
tttagatgta aaacacgttc aaaaaattta taaaacacgt tttcagggca accaagtaga   758460
agccctcaag gatattcact ttaccgtaga aaagggtgac tacgttgcca tcatgggtga   758520
gtctggttct ggtaaatcaa ctcttctcaa tattctagct atgttggata aaccaagtcg   758580
tggtcaggtt tacttgaatg gaactgacac cgcaactatt aaaaattcac aggcttctag   758640
tttccggcgt gaaaagctag gatttgtctt ccaagacttt aacttgctag atactctgtc   758700
tgttaaggac aatatcttgc ttccgcttgt cttgtcaaga agacctataa cggagatgat   758760
gaagaaattg gtggtgacag ctgagaatct gggtattaac caattgcaag agaagtaccc   758820
ttacgagatt tctggtggtc agaaacagcg tgtagcagta gcccgcgcca tcatcacaga   758880
acctgaaatt ctccttgcgg acgagccaac aggagccctt gattccaagt catctgcagc   758940
cttacttgat gtctttaatg aaatcaatga gcgtgggcaa accatcctca tggtaaccca   759000
ctcaacagca gctgctagca gggccaagcg tgttctcttt atcaaagacg gcattcttta   759060
caaccaaatc taccgtggag agaagacaga gcgtcagatg ttccaagaaa tctctgatac   759120
cttgactgtc atggcaagcg aggtgaatta gtatgtttcg attaaccaat aagttagcgg   759180
tatcgaactt gattaaaaac cgcaaactct actatccctt tgcactggct gttctcttgg   759240
cagtcaccat cacctatctc ttttactccc taaccttcaa tccaaagatt gcggaaatcc   759300
gtggaggaac caccattcaa gcaacacttg gatttggtat gtttgtcgtt acccttgcgt   759360
cagccattat cgtcctctat gccaatagtt ttgtcatgaa aaaccgttcc aaggaactgg   759420
gtatatatgg catgttaggc ttggagaagc gccatctaat cagtatgacc tttaaggagt   759480
tagtggtatt tgggattcta actgttggag cgggtatcgg tattggagcc ttgtttgaca   759540
agttaatttt cgctttcctg ctcaaactaa tgaaactgaa ggttgagctg gttgctacct   759600
tccaaatgaa tgttgtcatt gcagtacttg ttgtctttgg attgattttc ctaggcctca   759660
tgttcctgaa tgctcttcga atcgcccgta tgaatgccct ccagctctcg cgtgagaaag   759720
caagcggaga gaaaagaggt cgcttcctac ctctccaaac gattcttggt tccataagtt   759780
tagggattgg ctattatctt gcccttacgg taaccgatcc tcttacagcc ctaacaactt   759840
tcttcctagc tgttttgctg gttatctttg gtacttatct attgtttaat gcagggatta   759900
cagtcttcct acaaatctta aagaaaaaca agaaatacta ttaccaacct aataacctca   759960
tatctgtttc caacttgatt ttccgtatga agaaaaatgc ggttggacta gcaaccatcg   760020
ctattttgtc aacaatggtt ttggtaacca tgtcagcagc gacaagcatt ttcaattccg   760080
cagaaagctt taaaaaagtt ctaaatcctc atgattttgg ggtttcaggg caaaatgttg   760140
aaaaagaaga tttggacaaa ctcttgagcc agtttgcaag tgacaaaggt tatagtgtca   760200
aagagaaaga agtacttcgt tacagtaact ttggtattgc aaatcaagaa ggaaccaagt   760260
taactatttt tgaaaaagga caaaaccgtg tccaacccac aacagttttc atggtatttg   760320
accaaaaaga ttatgaaaat atgactggtc aaaaactgtc tctatcagga aatgaggtcg   760380
gtctctttgc caaaaatgac ggactgaaag gacagaaagc tctaactcta aatgatcatc   760440
aattttctgt caaagaagaa tttaataaag atttcattgt gaaccatgtt ccaaataagt   760500
ttaatatctt gactactgat tacaattacc ttgttgttcc tgatttacaa gcctttttgg   760560
atcaattccc agattcggct atctataatc agttttacgg tggtatgaat gtaaatgtca   760620
gtgaagaaga acaactcaag gtcgctgagg agtatgaaaa ctacctcaat caatttaatg   760680
ctcaattaga cacagaaggt agctatgttt atggtagcaa tctagcagat gctagttctc   760740
agatgagtgc cctctttggt ggtgtcttct ttatcggtat tttcctatcc attatcttta   760800
tggtcggaac tgttctggtc atctactaca aacaaatttc tgaaggctac gaagaccgtg   760860
aacgctttat tatcttgcag aaagtcggtt tggaccaaaa gcaaatcaag caaaccatca   760920
acaaacaggt tttaactgtt ttcttccttc ctttgctctt tgccttcata catctcgcct   760980
ttgcctacca tatgcttagc ctgattttaa aagtgattgg tgtactggat acgactatga   761040
tgttgattgt gaccttgtct atctgcgcta tcttcctcat cgcctatgtg ctgattttca   761100
tgattacttc aagaagttat cgcaagattg tgcaaatgta aaaaagatac ctcgacttca   761160
aaatcgaggt atttcttgta ttctaaatgc tgaaaagttg tccgagcagg aaggtaactc   761220
ccatggtcaa gagaccaata gcaaggttcc gaatcatagc tgttttggtt ggggcttttc   761280
caagtctagc acttgtgtaa ccagtgagaa gaagggccac accgacaata aggacggtag   761340
cagggatgcg gtaatcactt ggaaaaatgg tcactgacag cattggaggc aaacttctaa   761400
ggaaaaaggc aacgaagcta gaaatggcag cgtgccaagg attggtaaat tcttcatact   761460
caatcccata tttttcctct accagagcct tgagtggatt tttaagaaag atcttattgg   761520
tcaagagttg ggcagaagtt ttgaattctc cattttggat ataagcagca tagagggatt   761580
ttttggctag ttccctatct tggtctagca agagtttttc tcgcgaaacg gcagcttcct   761640
cggtatcttt tggagttgaa acggatacat attctccacc agccattgaa aaggcaccag   761700
ctaagatagc cgtaaaacct gataaaaaga taatccagat attggtcgtg gcactggcaa   761760
ctccgataac cacaccagca atggaaataa ttccatcgtt agcatcaaga acacccgcac   761820
gcaggatatt taaacgacct gcaaaatttg aatcaatttc gtgatttgtt tctgacgcta   761880
aatttcaagt tcaagttagc catcaagaag tcttctctgg gtgacttgta gtccaagcat   761940
tttttaggat agttgttaat ccacttttcg atgaatgcga cttctttggg agtcattttc   762000
ttggttccct taggtaacca tctacgaatg agcctgttgt gattctcatt agttcccctt   762060
tcccaagagg catagggatg tgcataataa atgtgctcct cagaaaatac attagacaag   762120
cgattgaatt ccgttccatt atctgccgtg atggaaagaa tcttgtgttg ttttaagatg   762180
agttttagag cctgattgac cacatcagca cttttatttg gaatcaatcg gatgatctga   762240
tgtctacttt ttcgatccgt caagacaagc aagcagtagt ttttcgctct cgtaagtaga   762300
actgtatcaa tctcataatg cccattctcc aagcgaaaat tgatagcttc aagccgctgt   762360
tcgatggatt gaccagcagg tttaaagttg gtgctggcct gtttcttaag cgcttttcct   762420
tttctagggt aaagcagatc ctgtttgctt aaccccaatt ttccatgatg aatccaatag   762480
taaatggttg aaattcccac gttaacccct ttagccatca ccatcatttc aggcgaaaat   762540
ttttggttat gatagtggag aatcttttcc tttagttcct tggtcaagct tgatttcttg   762600
accgagcgct tgcgattgtt ttcataagac tgttgagcat agtcggcaga ataaacctct   762660
ttgaagcgcc cttttccaag acattgtcgg actgtcccac gcttgatttc agtgtggata   762720
gtttgaggaa cttttccaag cagagaggca atttctctat ttgatttccc ttcttttttc   762780
catctttcga ttaagcgacg gctatcgatt gtcaaatgtt cgccttttgt agtataatgg   762840
ttttgcatct ctgtgccttt cttgtgtttg tggttgaaca acaagtataa cacagaggtg   762900
ttttcttatg cctacaagag ctatcggcta gttgaaccat ctaattttta ggagggctgg   762960
gtggctaact tcattataga actttcattt acgaacatat agtaaaatga aacaagaaca   763020
gaacaaatcg atcaggacag taaaatctat ttctaacaat gttttagaag cagaggtgta   763080
ctattctagt ttcaatctat tatatttttg ttttttatca aaaaatactt tacaagttct   763140
taaaaacatg atatagtaat aaagcttaga aaatgagatg atgttttcta gcaaatataa   763200
acccgagtaa aaaatgccta cggacaggca gggttgaatg ccgaagcgtg gttgaaaagc   763260
cacattattg atagggttaa aagcctactt ttataagttg atgttaggac acttgtccta   763320
attcataaat ttttagtgtg gtgaaagcac acgtcatctt gtgaaacgat caataaagta   763380
cgtaatattt gctactagag agttaggaaa catcgggaac agacatactc aacagaaacc   763440
aaaataaaca cgtcagaaga ttgcagagca ggtgaaaacc tgctcttttt tcatgagtca   763500
acctttagtt ccttagtttt cataaggtcc taaaaatatt gaaaggagta tgttttgaaa   763560
gagttagatc aaaaccaagc cccaatttat gaggccttgg tgaagttacg caagaaaagg   763620
attgttccct ttgatgttcc aggtcacaag cgtggacggg gaaatccaga acttgtcgaa   763680
ctcttaggag aaaaatgtgt aggcattgat gtcaattcga tgaaaccttt ggataattta   763740
ggccatccta tttcgattat tcgtgatgca gaggagctgg ctgcagatgc ttttggagct   763800
agccatgcct ttctaatgat tggtggaaca acttcatcgg tgcagactat gattctggca   763860
acctgcaagg caggagataa gattattctg ccacgaaatg tccataaatc tgctatcaat   763920
gcgttggttc tatgtggtgc cattcccatc tatatcgaga tgagtgtaga tcctaagatt   763980
ggtatcgctt taggtcttga aaatgaccga gtagcacagg ccataaagga ccatccagat   764040
gctaaggcta tcctaatcaa caatcctact tactacggca tctgttcaga cctaaagggg   764100
ttgacagaaa tggctcatga agctggcatg atggttttag tagatgaagc ccacggagcg   764160
catttgcatt tcactgataa acttccaatt tctgctatgg atgcaggggc tgatatggca   764220
gcagtttcca tgcataagtc tggtgggagt ttgacccaaa gctccatttt acttatcggg   764280
gagcagatga attctgaata cgttcgtcag ataattaacc tgacccagtc tacatctgcc   764340
tcttacttgt tgatggctag tttggatatt tcacgtcgca acttggccct tcgtggtaaa   764400
gagtcgtttg agaaagtcat tgagctatct gagtatgccc gccgtgaaat caatgctatc   764460
ggtggctact atgcctactc aaaagagtta atagacggtg tttcggtttg cgattttgac   764520
gtaactaagc tgtcagttta cactcagggt attggcttaa caggtatcga ggtttatgac   764580
ctcttgcgag acgaatacga cattcagatc gagtttggtg atatcggcaa tatcttggcc   764640
tatatttcca tcggcgaccg catccaagac atcgagcgct tggttggtgc tctggctgat   764700
attaagagac tctattcaag agatggaaaa gatttgatag caggagaata tattcagccc   764760
gagttagtgc tgtctccgca agaagccttc tattcagaaa gaaaaagttt aactttggat   764820
gattctgttg gacaggtctg tggagaattt gttatgtgtt accctccagg tattcctatc   764880
ttggctcctg gtgaacgcat tacacgagaa attgtcgact atatccaatt cgccaaggaa   764940
cgtggttgct ccctccaagg gacggaagat ccagaggtca atcatatcaa cgttattaag   765000
agaaagacaa actataagaa aagtcaatag ttttatctaa actatttctt atttcaattt   765060
gatgatttgg cgatgatttt agagcacggc aaaaagccct tgaattagaa gcggtcaatc   765120
gcttaatttc tatcagctta tcaaatcctg cctcaagcct tttctgagga ttagggtagc   765180
gtgtcaagag ttggtaggta tattctgaat gctttccaac gattttatcc aactcaggaa   765240
agatgatatc aagacaacga gtgtattgta ctttccaatc agactgtttt ttcttgagac   765300
gatgaatatg tctagccagt atttttagtt ctacttgccg attatcgtgt tgaaattgtt   765360
cacgattggg gtcagaaaga agtttaagag cgatgccatg agcgtctttc ttatccgttt   765420
tagttttgcg aagtgataat gatttggcaa atttcttgat gagcaaagga ttgtaggtgt   765480
aaactttata tccttgttca tgcaggaagt tcagtagatt aaaggcataa tgtccggtat   765540
tttcaagagc gatgagacag tcttggttga gctgtcgaag agacagatct aagagttcaa   765600
aaccagcttt attatttgaa aaagtgagtg gtttaagaac agtttttcct ggaacattca   765660
aggctgtaac atcgtgttta tttttagcga catcaatgcc cacataaagc atgggagtat   765720
ctccagatat agtatttcaa gtctactggg ttatccacga actttttgcc ttgttacctt   765780
agacgagata aaacgtctat gcgttatcaa actcattacc aattgaaaca aaaaactgtg   765840
gttagagcct ttcggaaatc gtcaagcgat tggaggaaat gaactaatcc acagtggctt   765900
attccaagta taccacttgg gctttggcag tagctaactg cgctaaatat aatataagga   765960
gaaatagatg gatttatggt tttctgaagt tcatactcca gatgtcaaat tgtctctgag   766020
aacagccaag caactttacg ctggaaaaag tgaatggcag gatatcgaag tcttggatac   766080
gccagctttt gggaaaatac tgattttaaa tggccatgtc ttgttctcag atgcggatga   766140
tttcgtctac aatgaaatga ccgttcacgt tcccatggct gtccacccaa atccaaagaa   766200
agtattggtt attgggggtg gtgacggcgg tgttgcccaa gtattaaccc tctatcctga   766260
actggagcaa attgatattg tggaaccgga tgagatgttg gtcgaggtct gtcgtgagta   766320
tttcccagac tttgctgcag ggctagatga tcctcgtgtt accatttact accaaaatgg   766380
gctacgcttt ttgcgaaact gcgaagatga ttacgatatt atcatcaacg atgcgacaga   766440
tccatttggc catacggaag gactctttac caaggaattc tacggcaata gttatcgagc   766500
tctgaaggaa gacggcatca tgatttacca gcatgggagt cccttctttg acgaggatga   766560
gtcggcctgc cgaagcatgc accgcaaggt caatcaagcc tttccaatca gtcgggttta   766620
tcaggcccat attccaacta gcccagctgg ctattggttg tttggatttg catcgaaaaa   766680
ataccaccct gtcaaagatt ttgacaagga aggctggaaa aaacgccagc ttttcacaga   766740
atactacact gcaaacttac acgtgggagc ctttatgttg cccaagtatg ttgaggacat   766800
tttagaagaa gaggaaggaa aaaaatgagt cgtttactag ttattggttg tgggggcgtt   766860
gcccaagttg ctatttcaaa gatttgtcaa gatagcgaaa catttacaga gattatgatt   766920
gctagccgta ccaagtcaaa atgcgatgac ttgaaagcga agctagaagg caaaacaagt   766980
actaaaattg aaactgcagc acttgatgct gacaaggttg aagaagtgat tgccctgatt   767040
gaaagctaca aaccagaagc tgttttgaat gtagctctgc cttatcaaga tttaaccatt   767100
atggatgctt gtttggcaac aggtgttcac tatatcgata cagccaacta cgaagcagaa   767160
gacacagaag accctgagtg gcgtgctatc tacgaaaaac gttgtaagga acttggtttt   767220
acagcctact ttgactactc atggcagtgg gcttatcaag agaaattcaa agaagcaggc   767280
ttgactgctc ttcttggttc tggttttgac ccaggtgtaa ctagtgtctt ttcagcttat   767340
gccctcaaac actattttga tgaaatccat tatatcgaca ttttagactg taatggcggt   767400
gaccacggtt atccatttgc aaccaacttt aatccagaaa ttaatctccg tgaggtttct   767460
gcgccaggtt cttactggga agatgggaaa tgggtcgaag tcgaagctat gtctatcaag   767520
cgtgagtatg atttccctca agttggacaa aaagatatgt atctccttca ccatgaagaa   767580
atcgaatcat tggccaagaa cattccaggt gtcaaacgca ttcgtttctt tatgactttt   767640
ggtcaatctt acttgacgca catgaaatgt cttgaaaatg ttggactcct tcgtacggat   767700
accattaact ttaacggcca agaaattgtt ccaattcaat ttttgaaagc cttgcttcca   767760
gatcctgcca gtcttgggcc acgtacagtc ggaaaaacca atattggatg tatctttaca   767820
ggtgtcaaag acggtgtcaa aaagactatc tatatctaca atgtctgcga ccatcaggaa   767880
tgttacgcag aggttggttc gcaagctatt tcttatacga caggagttcc agccatgatt   767940
gggacaaaat tagtcatgaa cggaacttgg aaacaagctg gagtgtataa ccttgaggag   768000
ttagatccag atccattcat ggaagctttg aatgagtatg gtttgccatg ggttgtggtt   768060
gaaaatccac aaatggtgga ctaatgaagt tagaacaagt accaacacca gcctatgtta   768120
ttgacttggc caagttagaa gctaattgcc gcattctaca atatgtacaa gaagaggccg   768180
gttgcaaggt cttgcttgcc cagaaggcat attccctcta caaaacttat cccttgatta   768240
gccagtatct atcaggtacg acagctagtg gactctatga ggccaaattg gcaagggaag   768300
aatttcctgg tgaagtccat gtatttgcgc ctgctttcaa ggatgcagac ttggaggaat   768360
tgctagagat aatggaccat atagtcttta actcagagag acagttgcgt aaacacggtc   768420
cgcgttgtcg agaggctggt gtcagtgttg gtttgcgcct caaccctcag tgttcaactc   768480
aaggagatca cgcgctctat gacccttgtg caccaggttc tcgctttgga gttactatag   768540
acaagattcc gagtgatttg ctagatttgg ttgacggact tcattttcat accctttgcg   768600
agcagggagc agatgattta caaacaactt tgaaagcagt agaagaacag tttggtccct   768660
acttacatga ggtaaaatgg ctcaatatgg gtggtggtca tcatattaca agagaaggtt   768720
acgatgtgga tttgctgatt tcagaaatca agcgtatccg aaaaacttac aatcttgaaa   768780
tctatatcga gcctggtgaa gccattgcgc ttaatgcggg ttatttagca actgaggtat   768840
tagatattgt agaaaacggt atggaaatct tggttttaga cgcctctgcg acctgccata   768900
tgcctgatgt acttgagatg ccctatcgtc cacctttgag aaatggcttt gagtcacagg   768960
aaaaagccca tacctacaga ctttcttcta atacctgtct gacgggcgat gtgattggtg   769020
attatagttt tgaaaatcca gtccaaatcg gagacagact ttattttcaa gacatggcca   769080
tttattcttt tgtcaaaaat aataccttta atggtattgg attgccaagt ctctatctca   769140
tggacgaaca gggagactgt agcttactca aagcttttgg ctatcaagac tttaaaggga   769200
gattatcatg atggacagtc caaaaaaatt aggctatcac atgccagcag agtacgaacc   769260
ccatcatggt accctcatga tatggccgac tcgaccagga tcatggcctt ttcaaggaaa   769320
ggctgctaaa agagcattta ctcagattat cgagaccata gcagaagggg aaagagtcta   769380
tcttttggtg gagcaggcct atctatctga agcccaatcc tatcttggag acaaggttgt   769440
ttatttagac attcccacca atgatgcctg ggcgcgtgat actggcccaa ccattctcgt   769500
caatgataaa ggtaagaaat tagccgtgga ttgggccttc aatgcttggg gaggcaccta   769560
tgatggtctt tatcaagatt atgaagagga tgaccaagta gccagtcgtt ttgctgaggc   769620
cttggaaagg cctgtctatg atgctaaacc ttttgtactg gaaggaggcg caatccatag   769680
cgatggtcaa ggaactattc tcgtaactga aagttgcttg cttagtcctg gtcgcaatcc   769740
taacttgact aaagaggaga ttgaaaacac attattagaa agtcttggtg ctgaaaaagt   769800
tatttggctt ccttatggta tttatcagga tgaaaccaat gaacacgtcg ataatgttgc   769860
tgcctttgtt ggtcctgctg agcttgtttt ggcttggaca gatgacgaaa atgatcccca   769920
gtatgccatg tcaaaagcag atctcgaact cttagaacag gaaacagatg caaaaggttg   769980
tcacttcacc attcataaat tgcctatccc tgcagttcga caagttgtga cagaagaaga   770040
tttgccaggc tacatctatg aagaaggaga agaaaagcga tacgcaggtg aacgactagc   770100
agcttcctac gtaaactttt atatcgccaa caaggctgtc ttggttccac agtttgagga   770160
tgtaaacgac caagtggcct tagatatcct cagcaagtgt ttcccagacc gtaaagttgt   770220
cggaatacca gccagagata ttctcttagg tggtggcaat atccactgta tcacccaaca   770280
aattccagaa taggagaaaa agatgagaaa tgtaagagtt gcaaccattc agatgcaatg   770340
cgctaaggat gtggcaacaa atatccaaac cgcagagcgt ttagtacgtc aggctgctga   770400
gcaaggagcc caaattattc tcttgcccga gttgtttgaa catccctatt tctgtcagga   770460
acgtcagtat gactactacc agtatgccca atctgtagcg gaaaatactg ccattcagca   770520
ttttaaggtg attgctaagg aactacaagt tgttttacca atcagtttct atgaaaaaga   770580
tggtaatgtc ttgtataact ctattgccgt cattgatgca gatggggaag tgctgggcgt   770640
ttatcgaaag acccatatac cagatgacca ttattatcaa gaaaaattct atttcacgcc   770700
tggtaacact ggtttcaagg tctggaatac tcgctatgct aagattggta tcggtatctg   770760
ttgggatcaa tggttccctg aaacagcgcg ctgtcttgca ttgaatggtg ctgaattgct   770820
cttttatcct acagctatcg gttcagagcc aattttggat acagatagtt gtggtcactg   770880
gcaacgtact atgcaagggc acgcagcagc gaatattgtt ccagtcatcg cagccaatcg   770940
ttatggttta gaggaggtta ctcctagtga ggaaaatggc ggacagagct ccagtcttga   771000
cttctacggt tcctccttta tgacggatga aacaggagct attctagaac gagctgaaag   771060
acaagaagaa gctgttctgt tagctactta tgacctagac aagggagcaa gtgaacgcct   771120
aaactggggc ttgtttcgag atagaagacc agaaatgtat agacaaatta cagattagtg   771180
tgggagaaat gagagattca ttctgctaga ctaacttctt attagtaact ataagatact   771240
atggcatcta gtaaatcgat ttttatgatt cgctattctt gtctattgat tagtccgtat   771300
tttaaaatat tagcaaaaaa gcaaatagca gtaacttctg tctatttgct tttctttttt   771360
atagaatata tttctcaata gcacgcgcaa cgccgtcttc ttcgttgctt gaggtaacgg   771420
catccgcaag agatttgata taatcgctgg catttcccat tgcaatccca agccctgcaa   771480
actggagcat ttcgatatcg ttattagcat cgcccatggc cataatctct gaggaatcaa   771540
tcttcaaaat ctcagctagt cgtgaaagag cagtagcctt tgtcgttcca agcggcattg   771600
cttcataaat gacaggctgc gaacgaactc cactgaatcg ttggcaaagc tcttcagcaa   771660
aacgctgctc aaaatcgtct gtttgttctt ttgttcctaa aaacatacct tggaacatcc   771720
ggaactttcc actagtcgct tcttcaagag aaatttcagt caggtctgaa aatactagtt   771780
tagcatcatt ttcaataact tgattgggct tgtcaccgag aacaaaataa tgtgactcgt   771840
caaaaagtgt caactgaaca tcactctttt cagcaaggtc atagaggtat tcgatgtcag   771900
ctggactcag ttctttccag tcaactagac tccaatcact ggtctggtga gttgaacaac   771960
cgttgttaac aataatatat tcgttctgga ggtcaagctc cagttttttg tagtagggga   772020
ggacaccgaa aagggggcga cccgtacaga gaaccagttt gacacctttt tcaatggctt   772080
tgtgaatagc agtaatgtga gcttgtggga tttccttggc ttcattgagg agggtgccgt   772140
ccatatccaa ggctagtagt ttaatcatag gtcttccttc tttatctttt gctattatta   772200
tagcatattt tggagaagaa attgatagaa agcttgagac taattgattt tatagtttaa   772260
gatgttttga tgacaattca tgatttgaag aggatatttc gcaaagatat gctatactat   772320
gtttgtcaat gttgcaacta gacaaattaa aaaaccaact taatataata gtttttttgt   772380
aagtaggtat gagtagcaga ttactcaact aatctgaaga ataatggagg aaatatatca   772440
tgattttaat gacaaaaaat ataaatctaa caaatgaaga attagagctg atacaaggtg   772500
gagcagatcc atatggtaaa aatcctaatg gtaggtacga ttgggaaata gaaccagtat   772560
taactctgct ggttcatgga ttttgtccca gaggcaccta tgattcagga tatattggag   772620
gaggtaatca tctttgcaaa ggaagtgctg cgagatttta agtaaaattt attaggaata   772680
tgaagaaaca aggggagaaa acagaggatt taatatgaaa aaacgagcta ttcaaatttt   772740
actagcattg tccttaattt tttacaaatc aacttggttt tggaggcttt tcaattatct   772800
cgcaaagccc tatctaccag caagtcgtga attttttcag attctgcttt tgatggagag   772860
cggagttctt ttcttagcgg tcatctatct actggttttt gcaggaaaga aaatttttca   772920
tttcaagtgg cagctgaggt acttcatcta ccttttactg ggctacatca tttcatatat   772980
gtctgacttc ctcttttcgt atttcatatc cctgtcttca aatcagattt ctttgaatga   773040
aacggtagaa atgatgggga gacaggagtt cccttatttc ttgctcatcg tttgcttcat   773100
cgcccctatt gctgaggaat tgatttatcg aggtgtgctt atgacaacct ttttcaaaaa   773160
ctcaccttgg tacggagatg ttttgctttc tgctattatt ttcggttata ttcatatcaa   773220
ttttgcttta actcctcttg cttttttcat ttatgctagt ggaggtctta ttttagctct   773280
attgtatcgc atgactaaaa atctctacta tccaatacta gttcatattc tcattaatat   773340
cactgccttc tgggatgtgt ggttgctcct attttcagga agttagctta ctaaaataat   773400
gtcggaactt tccggcattt tcttttttca caaatagtca acgtttttct tttcgatatt   773460
gtagtggtgt gtatccagtt atttttttga attgattttg aaaataaggt tgacttgaga   773520
aaggcagata gtgaagatag ttaagaagaa taggatgttc ttttttcctt tttggaaaac   773580
ttctaaaata tggtataatg aaaagataaa gaagttgggg gtagaagatg aacattcaac   773640
aattacgcta tgttgtggct attgccaata gtggtacttt tcgtgaagct gctgaaaaga   773700
tgtatgttag tcagccgagt ctgtctattt ctgttcgtga tttggaaaaa gagttgggct   773760
ttaagatttt ccgtcggacc agctcaggga ctttcttgac ccgtcgtggg atggaatttt   773820
atgaaaaatc gcaagaattg gttaaaggat ttgatatttt tcaaaatcag tatgccaatc   773880
ctgaagaaga aaaagatgaa ttttctgttg ctagccagca ctatgacttc ttgccaccaa   773940
ctattacggc cttttcagag cgctatcctg actataagaa cttccgtatt tttgaatcaa   774000
ctactgttca aatattagat gaagtggcgc aagggcatag tgagattggg attatctacc   774060
tcaacaatca aaataaaaag gggattatgc aacgggttga aaaattaggt ctggaggtca   774120
tcgaattgat tcctttccat acccatattt atctccgtga gggtcatcct ttagcccaga   774180
aagaggaatt agtcatggag gatttagcgg atttaccaac ggttcgtttc actcaagaga   774240
aagacgagta cctttattat tcagagaact ttgtcgatac cagcgctagc tcacagatgt   774300
ttaatgtgac agaccgtgcc accttgaatg gtattttgga gcggacggac gcctatgcga   774360
caggttctgg atttttagat agtgacagtg ttaatggcat tacagttatt cgtctcaagg   774420
ataacctaga taaccgcatg gtctatgtta aacgtgaaga agtggagctt agtcaagctg   774480
ggactctctt cgtagaagtc atgcaagaat attttgatca aaagaggaaa tcatgaaaaa   774540
aagagcaata gtggcagtca ttgtactgct tttgattggg ctggatcagt tggtcaaatc   774600
ctatatcgtc cagcagattc cactgggtga agtgcgctcc tggatcccca atttcgttag   774660
cttgacctac ctgcaaaatc gaggtgcagc cttttctatc ttacaagatc agcagctgtt   774720
attcgctgtc attactctgg ttgtcgtgat aggtgccatt tggtatttac ataaacacat   774780
ggaggactca ttctggatgg tcttgggttt gactctaata atcgcgggtg gtcttggaaa   774840
ctttattgac agggtcagtc agggctttgt tgtggatatg ttccaccttg actttatcaa   774900
ctttgcaatt ttcaatgtgg cagatagcta tctgacggtt ggagtgatta ttttattgat   774960
tgcaatgcta aaagaggaaa taaatggaaa ttaaaattga aactggtggt ctgcgtttgg   775020
ataaggcttt gtcagatttg tcagaattat cacgtagtct cgcgaatgaa caaattaaat   775080
caggccaggt cttggtcaat ggtcaagtca agaaagctaa atacacagtc caagagggtg   775140
atgtcgtcac ttaccatgtg ccagaaccag aggtattaga gtatgtggct gaggatcttc   775200
cgctagaaat agtctaccaa gatgaggatg tggctgtcgt taacaaacct cagggaatgg   775260
ttgtgcaccc gagtgctggt cataccagtg gaaccctagt aaatgccctc atgtatcata   775320
ttaaggactt gtcgggtatc aatggggttc tgcgtccagg gattgttcac cgtattgata   775380
aggatacgtc aggtcttctc atgattgcta aaaacgatga tgcgcatcta gcacttgccc   775440
aagaactcaa ggataaaaag tctctccgca aatattgggc gattgttcat ggaaatctac   775500
ctaatgatcg tggtgtaatt gaagcgccga ttggccggag tgaaaaagac cgtaagaaac   775560
aggctgtaac tgctaaaggg aagcctgcag tgacgcgttt tcacgtcttg gaacgctttg   775620
gcgattatag cttagtagag ttgcaactgg agacagggcg cactcatcaa atccgtgtcc   775680
acatggctta tatcggccat ccagtcgctg gtgatgaggt ctatggtcct cgcaagactt   775740
tgaaaggaca tggacaattt cttcatgcca agactttagg ttttactcat ccgagaacag   775800
gtaagacctt ggaatttaaa gcagatatcc cagagatttt taaggaaacc ttggagagat   775860
tgagaaagta agaatgaaaa agaaattaac tagtttagca cttgtaggcg cttttttagg   775920
tttgtcatgg tatgggaatg ttcaggctca agaaagttca ggaaataaaa tccactttat   775980
caatgttcaa gaaggtggca gtgatgcgat tattcttgaa agcaatggac attttgccat   776040
ggtggataca ggagaagatt atgatttccc agatggaagt gattctcgct atccatggag   776100
agaaggaatt gaaacgtctt ataagcatgt tctaacagac cgtgtctttc gtcgtttgaa   776160
ggaattgggt gtccaaaaac ttgattttat tttggtgacc catacccaca gtgatcatat   776220
tggaaatgtt gatgaattac tgtctaccta tccagttgac cgagtctatc ttaagaaata   776280
tagtgatagt cgtattacta attctgaacg tctatgggat aatctgtatg gctatgataa   776340
ggttttacag actgctgcag aaaaaggtgt ttcagttatt caaaatatca cacaagggga   776400
tgctcatttt cagtttgggg acatggatat tcagctctat aattatgaaa atgaaactga   776460
ttcatcgggt gaattaaaga aaatttggga tgacaattcc aattccttga ttagcgtggt   776520
gaaagtcaat ggcaagaaaa tttaccttgg gggcgattta gataatgttc atggagcaga   776580
agacaagtat ggtcctctca ttggaaaagt tgatttgatg aagtttaatc atcaccatga   776640
taccaacaaa tcaaatacca aggatttcat taaaaatttg agtccgagtt tgattgttca   776700
aacttcggat agtctacctt ggaaaaatgg tgttgatagt gagtatgtta attggctcaa   776760
agaacgagga attgagagaa tcaacgcagc cagcaaagac tatgatgcaa cagtttttga   776820
tattcgaaaa gacggttttg tcaatatttc aacatcctac aagccgattc caagttttca   776880
agctggttgg cataagagtg catatgggaa ctggtggtat caagcgcctg attctacagg   776940
agagtatgct gtcggttgga atgaaatcga aggtgaatgg tattacttta accaaacggg   777000
tatcttgtta cagaatcaat ggaaaaaatg gaacaatcat tggttctatt tgacagactc   777060
tggtgcttct gctaaaaatt ggaagaaaat cgctggaatc tggtattatt ttaacaaaga   777120
aaaccagatg gaaattggtt ggattcaaga taaagagcag tggtattatt tggatgttga   777180
tggttctatg aagacaggat ggcttcaata tatggggcaa tggtattact ttgctccatc   777240
aggggaaatg aaaatgggct gggtaaaaga taaagaaacc tggtactata tggattctac   777300
tggtgtcatg aagacaggtg agatagaagt tgctggtcaa cattattatc tggaagattc   777360
aggagctatg aagcaaggct ggcataaaaa ggcaaatgat tggtatttct acaagacaga   777420
cggttcacga gctgtgggtt ggatcaagga caaggataaa tggtacttct tgaaagaaaa   777480
tggtcaatta cttgtgaacg gtaagacacc agaaggttat actgtggatt caagtggtgc   777540
ctggttagtg gatgtttcga tcgagaaatc tgctacaatt aaaactacaa gtcattcaga   777600
aataaaagaa tccaaagaag tagtgaaaaa ggatcttgaa aataaagaaa cgagtcaaca   777660
tgaaagtgtt acaaattttt caactagtca agatttgaca tcctcaactt cacaaagctc   777720
tgaaacgagt gtaaacaaat cggaatcaga acagtagtag aaaagaaggt tttagggcct   777780
tctttttcct atcaactctt ttctatttcc tgttattcat gttataatgg ataaatatga   777840
ataatcggag tgagactatg aaatacaaac ggattgtctt taaggtgggt acttcttctc   777900
tgacaaatga ggatggaagt ttatcacgta gtaaggtaaa ggatattacc cagcagttgg   777960
ctatgctgca cgaggctggt catgagttga ttttggtgtc ttcaggtgcc attgcggctg   778020
gttttggagc cttaggattt aaaaagcgtc cgactaagat tgctgataaa caggcttcag   778080
cagcggtagg gcaggggctt ttgttggaag aatatacaac caatcttctc ttgcgtcaaa   778140
tcgtttctgc acaaatcttg ctgacccaag atgactttgt ggataagcgt cgttataaaa   778200
atgcccatca ggctttgtcg gttttgctca accgtggggc aattcctatc atcaatgaga   778260
atgatagtgt cgttattgat gagctcaagg ttggggacaa tgacactcta agtgctcaag   778320
tagcggcgat ggtccaagca gaccttttag ttttcttgac agatgtggac ggtctctata   778380
ctggaaatcc taattcagat ccaagagcca aacgcttgga gagaatcgag accatcaatc   778440
gtgagattat tgatatggct ggtggagctg gttcgtcaaa cggaactggg ggtatgttaa   778500
ccaaaatcaa ggctgcaact atcgcgacgg aatcaggagt tcctgtttat atctgctcat   778560
ccttgaaatc agattccatg attgaggcgg cagaggagac cgaggatggt tcttactttg   778620
ttgctcaaga gaaggggctt cgtacccaga aacaatggct tgccttctat gctcagagtc   778680
aaggttctat ttgggttgat aaaggggctg cggaagctct ctctcaatat ggaaagagtc   778740
ttctcttatc tggtatcgtt gaagcagaag gagtcttttc ttacggtgat atcgtgacag   778800
tatttgacaa ggaaagtgga aaatcacttg gaaaaggacg cgtgcaattt ggagcatctg   778860
ctttggagga tatgttgcgt tctcaaaaag ccaagggtgt cttgatttac cgtgacgact   778920
ggatttccat tactcctgaa atccaactac tttttacaga attttagagg taaactatgg   778980
tgagtagaca agaacaattt gaacaggtac aggctgttaa aaaatcgatt aacacagcta   779040
gtgaagaagt gaaaaaccaa gccttgctag ccatggctga tcacttagtg gctgctactg   779100
aggaaatttt agcggctaat gccctcgata tggcagcggc taaggggaaa atctcagatg   779160
tgatgttgga tcgtctttat ttggatgcag atcgtataga agcgatggca agaggaattc   779220
gtgaagtggt tgccttacca gatccaatcg gtgaagtttt agaaacaagt cagcttgaaa   779280
atggtttggt tatcacaaaa aaacgtgtag ctatgggtgt catcggtatt atctatgaaa   779340
gccgtccaaa tgtgacgtct gatgcggctg ctttgactct taagagtgga aatgcggttg   779400
ttcttcgtag tggtaaggat gcctatcaaa caacccatgc cattgtcaca gccttgaaga   779460
agggcttgga gacgactact attcatccaa atgtgattca actggtggag gatactagcc   779520
gtgaaagtag ttatgctatg atgaaggcca agggctatct agaccttctc attcctcgtg   779580
gaggagctgg cttgatcaat gcagtggttg agaatgcgat tgtacctgtt atcgagacag   779640
ggactgggat tgtccatgtc tatgtggata aggatgcaga cgaagacaag gcgctgtcta   779700
tcatcaacaa tgctaaaacc agtcgtcctt ctgtttgtaa tgccatggag gttctgctgg   779760
ttcatgaaaa caaggcagca agcttccttc ctcgcttgga gcaagtgttg gttgcagagc   779820
gtaaggaagc tggactggaa ccaattcaat tccgcctaga tagcaaagca agccagtttg   779880
tttcaggtca agcagctgag acccaagact ttgacaccga gtttttagac tatgtccttg   779940
ctgttaaggt tgtgagcagt ttagaagaag cggttgcgca cattgaatcc cacagcaccc   780000
atcattcgga tgctattgtg acggaaaatg ctgaagctgc agcatacttt acagatcaag   780060
tggactctgc agcggtgtat gttaatgcct caactcgttt cacagatgga ggacaatttg   780120
gtcttggttg tgaaatgggg atttctactc agaaattgca cgcgcgtggt cccatgggct   780180
tgaaagagtt gaccagctac aagtatgtgg ttgccggtga tgggcagata agggagtaag   780240
agatgaagat tggatttatc ggtttgggga atatgggtgc tagcttggca aaatctgtct   780300
tgcagactag gacgtcagat gagattctcc ttgccaatcg tagtcaagct aaggtagatg   780360
ctttcattgc agactttggt ggtcaggctt ccagcaatga agaaatgttt gcagaagcag   780420
atgtgatttt tctaggagtt aagcctgctc agttttctga actgctttct caataccaga   780480
ccatccttga aaaaagagaa agtcttcttt tgatttcgat ggcagctgga ttgaccttag   780540
aaaaactagc aagtcttatc ccaagtcaac accgaattat tcgtatgatg cctaataccc   780600
ctgcttctat cgggcaagga gtgattagtt atgccttgtc tcctaattgc agggctgagg   780660
acagtgagct cttttatcag cttttagcca aggctggtct cttggttgaa ctaggagaaa   780720
gtttaatcga tgcagcgaca ggtcttgcag gttgtggacc agcctttgtc tatcttttta   780780
tcgaggcctt ggcagatgca ggtgttcaga caggattacc acgagaaata gcattgaaaa   780840
tggcagcaca aactgtggta ggagctgggc aattggtcct tgaaagtcag caacatcctg   780900
gagtattgaa agaccaagtc tgtagcccag gcggttcgac tatcgctggt gtagcaagcc   780960
tagaagcgca tgctttccga ggaacagtca tggatgcagt tcatcaagcc tacaaacgaa   781020
cacaagaact aggtaaataa gaggtagttt tgactgcctc ttttatggtg gctgaaatga   781080
gaagacacaa aaagattgtc acaaacccct atttttttga tagaatagaa gtagtaaaaa   781140
agaaatgagt tagacatgtc aaaaggattt ttagtctctc ttgagggacc agagggagca   781200
ggcaagacca gtgttttaga ggctctgcta ccaattttag aggaaaaagg agtagaggtg   781260
ttgacgaccc gtgaacctgg cggagtcttg attggggaga agattcggga agtgattttg   781320
gatccaagtc atactcagat ggatgctaaa acagagctac ttctctatat tgccagtcgc   781380
agacagcatt tggtggaaaa agttcttcca gcccttgaag ctggcaagtt ggtcatcatg   781440
gatcgtttta tcgatagttc tgttgcctat cagggatttg gtcgtggctt agatattgaa   781500
gccattgact ggctcaatca gtttgcgaca gatggcctca aacccgattt gacactctat   781560
tttgacatcg aggtggaaga agggctggct cgtattgctg ctaatagtga ccgcgaggtt   781620
aatcgtttgg atttggaagg gttggacttg cataaaaaag ttcgtcaagg ctacctttct   781680
cttctggata aagagggaaa tcgcattgtc aagattgatg ctagtctccc tttggagcaa   781740
gttgtggaaa ctaccaaggc tgtcttgttt gacggaatgg gcttggccaa atgaaacaag   781800
atcaactaaa ggcttggcaa ccagctcagt ttgaccgttt tgtccgtatc ttagaacaag   781860
accagctcaa tcacgcctat ctcttttcag gtttctttga aagcttggaa atggcgcaat   781920
ttttagctaa gagcctcttt tgtacggata aagttggcgt cttaccatgt gagaaatgcc   781980
gaagttgcaa gctgattgaa cagggagaat ttcccgatgt caccttgatt aaaccagtta   782040
atcaggtcat taagacggaa cgcattcgag aattggtggg tcagttttct caagcaggga   782100
ttgaaagcca gcaacaggtc tttatcatcg agcaagcgga taaaatgcat cccaacgcag   782160
ccaattctct gctcaaggtc atcgaagaac cccagagtga agtttatatt ttcttcttga   782220
ctagcgatga ggaaaagatg ttaccgacaa tccgaagtcg gactcagatc ttccacttta   782280
aaaagcaaga agaaaaactt atcttactct tagaacaaat gggacttgtt aagaaaaaag   782340
cgactctttt agctaagttt agtcaatcgc gagctgaagc agaaaagttg gctaatcagg   782400
caagtttttg gaccttggtc gatgaaagtg aacgcctgct gacttggtta gtagctaaga   782460
aaaaagaaag ttatctacag gttgccaaat tagccaactt ggcagatgat aaggaaaaac   782520
aggatcaggt tttacggatt cttgaagttc tctgtgggca ggacctcttg caggtaagag   782580
taagagtgat tctacaagat ttactagaag ctagaaaaat gtggcaagct aatgtcagct   782640
ttcaaaatgc catggaatat ctggtcttga aagaaatata aactcaaaaa tgaatgataa   782700
agaaaggaaa gggctgtttt atggacaaaa aagaattatt tgacgcgctg gatgattttt   782760
cccaacaatt attggtaacc ttagccgatg tggaagccat caagaaaaat ctcaagagcc   782820
tggtagagga aaatacagct cttcgcttgg aaaatagtaa gttgcgagaa cgcttgggtg   782880
aggtggaagc agatgctcct gtcaaggcca agcatgttcg tgaaagtgtc cgtcgcattt   782940
accgtgatgg atttcacgta tgtaatgatt tttatggaca acgtcgagag caggacgagg   783000
aatgtatgtt ttgtgacgag ttgctataca gggagtaggc atgcagattc aaaaaagttt   783060
taaggggcag tctccctatg gcaagctgta tctagtggca acgccgattg gcaatctaga   783120
tgatatgact tttcgtgcta tccagacctt gaaagaagtg gactggattg ctgctgagga   783180
tacgcgcaat acagggcttt tgctcaagca ttttgacatt tccaccaagc agatcagttt   783240
tcatgagcac aatgccaagg aaaaaattcc tgatttgatt ggtttcttga aagcagggca   783300
aagtattgct caggtctctg atgccggttt gcctagcatt tcagaccctg gtcatgattt   783360
agttaaggca gctattgagg aagaaattgc agttgtgaca gttccaggtg cctctgcagg   783420
aatttctgcc ttgattgcca gtggtttagc gccacagcca catatctttt acggtttttt   783480
accgagaaaa tcaggtcagc agaagcaatt ttttggcttg aaaaaagatt atcctgaaac   783540
acagattttt tatgaatcac ctcatcgtgt agcagacacg ttggaaaata tgttagaagt   783600
ctacggtgac cgctccgttg tcttggtcag ggaattgacc aaaatctatg aagaatacca   783660
acgaggtact atctctgagt tattagaaag cattgctgaa acgccactca agggcgaatg   783720
tcttctcatt gttgagggtg ccagtcaggg tgtggaggaa aaggacgagg aagacttgtt   783780
cgtagaaatt caaacccgca tccagcaagg tgtgaagaaa aaccaagcta tcaaggaagt   783840
cgctaagatt taccagtgga ataaaagtca gctctacgct gcctaccacg actgggaaga   783900
aaaacaataa agggagacag gatgtaataa ttctgtctgt ttctgtttaa cttaattagt   783960
gatgataata taaagatgta tcacttggta tagaagcttt ggtattaagt tttttattaa   784020
gcccatacgg aataccgatg gttggagcag cagttatagc gttcttagaa ggtataaata   784080
gaaaaataag gtcattttaa atcaaaggat tgataaatca gaaagaaggt gattttttgc   784140
gaacatacga aaataaagaa gaactaaaag ctgagataga gaaaacattt gagaaatata   784200
ttttagaatt tgataatatt ccagaaaatt taaaagataa gagagctgat gaagttgaca   784260
gaactccagc agaaaacctt gcttatcagg ttggttggac caacttggtt cttaaatggg   784320
aagaagatga aagaaagggg cttcaagtaa aaacaccatc ggataaattt aaatggaatc   784380
aacttggtga attatatcag tggttcacag atacctacgc tcatttatct ctgcaagagt   784440
tgaaagcaaa attaaatgaa aatattaatt ctatctctgc aatgattgat tcgttgagtg   784500
aggaagaatt atttgaaccg catatgagaa agtgggctga tgaagcgact aaaacagcga   784560
cttgggaagt gtataagttt attcatgtaa atacggttgc accttttgga actttcagaa   784620
ctaaaatcag aaaatggaag aagatagtat tataaattat atttttaact ttaaaaaatt   784680
tcataaaaat ggttaccaaa ggcgatagaa gaaaaactat cgtctttttc tttgcaaatt   784740
tttaagaagg gaggtgatct tgcatggact ttgaatattt ttataacaga gaagcggaaa   784800
gatttaactt cttaaaagta ccggagatat tagttgatag agaagaattt cggggcttat   784860
cagcagaagc aattatcctt tattccatac ttcttaaaca gacaggaatg tcatttaaga   784920
ataactggat agacaaggaa ggcagagtat ttatctattt tactgtcgaa gaaattatga   784980
aaagaagaaa tatctcaaag ccaactgcca taaaaacatt agatgagctt gatgtaaaaa   785040
aggaatagga ctgatcgaaa gagtaaggct tggacttggt aagccgaaca tcatttatgt   785100
taaagacttt atgagtatat ttcaggtaaa agaaaatgac ttacagaagt caaaaaactt   785160
aacttcagaa gtaaaagatt ttaacctcag aagtaaagaa aatgaacttc aagaggttaa   785220
gaaccttgac tctaactata tagagaataa taagagtaag tatagtaaga gagaatatag   785280
ttttggtgaa aacggacttg gaacatttca aaatgtgttt ttagctgctg aagatatatc   785340
ggatttacaa atcataatga actcacagct tgagaattac attagacttc ctgcaaaact   785400
agaatcctag ttcatgattg ataatgccag caatcaaatt cattcgtaat ccgaagcgtt   785460
tacgatgatt tcgatagatt gttgaaaaca ttttaaacgt ttttactttg gcaaagatgt   785520
tctcaatctt gcttctctcc ttggatagcg catggttaca ggctttatct tcagctgtta   785580
gcggcttgag tttgctggat ttacgtggag tttgtacttg aggatatatc ttcatgagcc   785640
cttgataacc actgtcagac aagattttac cagcttgtcc gatatttctg cgactcattt   785700
tgaacaactt catatcacga caatagttca cagcgatatc caaagaaaca attctccctt   785760
gacttgtgac aatcgcttga gccttcatag cgtgaaattt ctttttacca gaatgattcg   785820
ctaattcttt ttttagggcg attgattttt acttccgtcg catcaatcat taccgtgtcc   785880
tcagaactga gaggagttct tgaaatcgta acaccacttt gaacaagagt tacttcaacc   785940
cattggctcc gacggattaa gttgctttcg tgaataccaa aatcagccgc aatttgttca   786000
taagttcgat attctcgcac atattgaaga gtggccataa gaaggtcttc taggcttaat   786060
ttaggttttc gtccaccttt tgcgtgttta agttgataag ctgtttttaa tacagctaat   786120
atctcttcaa aagtcgtgcg ctgaacacca acaagacgct taaatcgtgc atcagttagt   786180
tgtttacttg cttcatcatt catagaacta ctataccata ttttgtttcg caggaagtct   786240
attggaaagt aagaaatatt gaagctgagg ctattagaag aaattgtgag cgtggtgcta   786300
ttttttcagg taaaataaaa tatcacgaag attcacagtt taaaggagat cactatgttg   786360
aatgttatgc tgttttagat aatacggtta tagcaagaga tagaataaca gtccctatcg   786420
atccgttatg tggaaaagat tttatagagt agcatataat tgattcttaa ctggaatact   786480
cactatctct ttacatcaag aaaatgacta aacagggaag tttgccttct tccctttttt   786540
tgttatacta gtagaagaaa aaattagaaa gatttgtggg tgtcaaacag cccagtgggg   786600
tgttttaata tggacttagg tcccacccaa agaggtatta gtgtcgtgtc tcaatcttat   786660
atcaatgtta tcggtgctgg tttggcaggt tctgaagcag cttaccaaat cgcagagcgt   786720
ggtattccag ttaaactata tgaaatgcgt ggtgtcaagt ctacacccca gcataaaaca   786780
gacaattttg ctgagttggt ttgttccaat tctttgcgtg gggatgcttt gacaaatgca   786840
gttggtcttc tcaaggaaga aatgcgtcgc ttgggttctg ttatcttgga atctgctgag   786900
gctacacgtg ttcctgcagg tggtgccctt gcagtggacc gtgatggttt ctctcaaatg   786960
gtgaccgaaa aagttgccaa ccaccccttg attgaagtgg ttcgtgatga aattacagaa   787020
ttgccgacag atgttattac ggttatcgct actggtcctt tgacaagtga tgccttggct   787080
gaaaagattc atgctcttaa tgacggtgct ggtttttatt tctacgatgc ggcagcgcct   787140
attatcgatg tcaacactat cgatatgagc aaggtctacc tcaaatcacg ttatgataag   787200
ggagaagcgg cctacctcaa tgcccctatg accaagcaag aatttatgga tttccatgaa   787260
gctttggtca atgcagaaga agcaccgctt agttcttttg aaaaagaaaa gtactttgaa   787320
ggatgtatgc ctatcgaagt catggccaaa cgtggcatta aaactatgct ttatggccct   787380
atgaagccag tcggtcttga gtacccagac gactatacag gacctcgtga tggagaattt   787440
aaaacacctt atgcggttgt gcaacttcgt caggataatg cagctggtag cctctacaat   787500
attgttggtt tccagaccca cctcaaatgg ggagaacaaa agcgtgtctt ccaaatgatt   787560
ccgggtcttg aaaatgcgga gtttgtccgt tatggtgtga tgcatcgcaa ttcttacatg   787620
gattcaccaa atcttcttga gcagacttac cgttctaaga aacaaccaaa tctcttcttt   787680
gctggtcaaa tgacgggtgt ggaaggctat gttgagtcgg cggcttcagg cttagttgcg   787740
ggaattaacg cagctcgtct cttcaaggaa gaaagcgagg ctattttccc cgagacgaca   787800
gcgattggaa gcttagctca ttacattacc catgccgaca gcaaacattt ccaaccaatg   787860
aatgtcaatt ttgggatcat caaggagttg gaaggcgagc gtatccgtga taagaaggct   787920
cgttatgaaa aaattgcaga gcgtgccctt gccgacttag aggaattttt gactgtctaa   787980
tttttttgaa agaattgctc atgatactat aaaaatctta gaaattgtga taaaataggt   788040
aggatgaaag aaggagagtg aaaatggcga atcccaagta taaacgtatt ttaatcaagt   788100
tatcaggtga agcccttgcc ggtgaacgtg gcgtagggat tgatatccaa acagttcaaa   788160
caatcgcaaa agagattcaa gaagttcata gcttaggtat cgaaattgcc cttgttatcg   788220
gtggaggaaa tctctggcgt ggagaacctg cagcagaagc aggtatggac cgtgttcagg   788280
cagattacac aggaatgctt gggactgtta tgaatgctct tgtgatggca gattcattgc   788340
aacaagttgg ggttgatacg cgtgtacaaa cagctattgc catgcaacaa gtggcagagc   788400
cttatgtccg tggacgtgcc cttcgtcacc ttgaaaaagg ccgtatcgtt atctttggtg   788460
ctggaattgg ttcaccttac ttctcgacag atacaacagc ggcccttcgt gcagctgaaa   788520
tcgaagcaga tgccatcctc atggctaaaa atggtgtcga tggtgtttac aatgccgatc   788580
ctaagaaaga taagacagct gttaagtttg aagaattgac ccaccgtgac gttatcaata   788640
aaggtcttcg tatcatggac tcaacagctt caaccctctc aatggacaac gacattgact   788700
tggttgtatt caacatgaac caaccaggca acatcaaacg tgtcgtattt ggtgaaaata   788760
tcggaacaac agtttcaaat aatatcgaag aaaaggaata agaaagaata tggctaacgc   788820
aattattgaa aaagctaaag agagaatgac ccagtctcac caatcacttg ctcgtgaatt   788880
tggtggtatc cgtgctggtc gtgccaatgc aagcttgctt gaccgtgtac atgtagaata   788940
ctatggagtc gaaactcctc ttaaccaaat cgcttcaatt acgattccag aagcgcgtgt   789000
tttgttggta acaccatttg acaagtcttc attgaaagac atcgaacgtg ccttgaacgc   789060
ttctgatatt ggtatcacac cggctaatga cggttctgtg attcgcttgg ttatcccagc   789120
tcttacagaa gaaactcgtc gtgaccttgc taaagaagtg aagaaggtcg gcgaaaatgc   789180
taaagtggct gtccgcaata tccgtcgcga tgctatggac gaagctaaga aacgagaaaa   789240
agcaaaagaa atcactgaag acgaattgaa gactcttgaa aaagacattc aaaaagtaac   789300
agacgatgct gttaaacaca tcgacgacat gactgctaac aaagagaaag aacttttgga   789360
agtctaaaaa taaacagaaa aactcagttg gcattgctgg ctgagtttta ttcgaaagaa   789420
ggaaatatga atacaaatct tgcaagtttt atcgttggac tgatcatcga tgaaaacgac   789480
cgtttttact ttgtgcaaaa ggatggtcaa acctatgctc ttgctaagga agaaggccaa   789540
catacagtag gggatacggt caaaggtttt gcatacacgg atatgaagca aaaactccgc   789600
ctgacaacct tagaagtgac tgccactcag gaccaatttg gttggggacg tgtcacagag   789660
gttcgtaagg acttgggtgt ctttgtggat acaggccttc ctgacaagga aatcgttgtg   789720
tcactcgata ttctccctga gctcaaggaa ctctggccta agaagggcga ccaactctac   789780
atccgtcttg aagtggataa gaaagaccgt atctggggcc tcttggctta tcaagaagac   789840
ttccaacgtc ttgctcgtcc tgcctacaac aacatgcaga accaaaactg gccagccatt   789900
gtttaccgtc tcaagctgtc aggaactttt gtttacctac cagaaaataa tatgcttggt   789960
tttattcatc ctagcgagcg ttacgcagag ccacgtttgg ggcaagtatt agatgcgcgc   790020
gttattggtt tccgtgaagt ggaccgcact ctgaacctct ccctcaaacc acgctccttt   790080
gaaatgttgg aaaacgatgc tcagatgatt ttgacttatt tggaaagcaa tggcggtttc   790140
atgaccttaa atgacaagtc atctccagac gacatcaagg caacctttgg catttctaaa   790200
ggtcagttca agaaagcttt aggtggtctt atgaaggctg gtaaaatcaa gcaggaccag   790260
tttgggacag agttgattta gggaggctta tgagaaaatc attttacact tggctcatga   790320
ccgagcgcaa tcctaaaagt aacagtccca aagcaatttt ggcagacctc gcttttgaag   790380
agtcagcctt tccaaaacac acagatgatt ttgatgaggt cagtcgcttt ttggaggagc   790440
atgccagttt ctcttttaac ctaggagatt ttgacagcat ttggcaggaa tatctagaac   790500
actagcattt attcattggg tttgggctag taatttctcc atccctctgc tataataaaa   790560
agaaataaaa ggattagaga ggttctttat ttgaaggaac attcaataga cattcaactg   790620
agtcatccag atgacctgtt tcatcttttt ggttccaatg aacgccatct tcgtttgatg   790680
gaagaagagc ttgatgttgt gattcatgct cgtacggaga ttgtccaggt tttgggagaa   790740
gagtctgcct gtgaggaagc ccgtcaagtt attcaggctt tgatggtctt ggtaaatcgt   790800
gggatgaccg ttggtacgcc agatgtagtc actgcgatta gcatggtcaa aaatgatgaa   790860
attgacaagt ttgtcgccct ttacgaagaa gaaattatca aggataatac tgggaaacct   790920
atccgtgtca aaaccctagg gcaaaagctt tatgtggaca gtgtcaaaca gcatgatgtg   790980
acctttggaa ttgggccagc aggtacaggg aagaccttcc ttgcagtgac cttggcagtg   791040
actgccctta aacgtgggca agtcaagcga attatcctaa ctcgtccagc ggtggaagcg   791100
ggagagagtc ttggatttct tccgggtgat cttaaggaga aggtggatcc ttaccttcgt   791160
cctgtttacg atgccttgta tcaaattctt gggaaagacc aaacgactcg tctcatggag   791220
cgtgaaatta tcgaaattgc gccccttgcc tatatgcgtg gccggacctt ggatgatgcc   791280
tttgtcattc tcgatgaggc gcaaaacacg accatcatgc agatgaagat gttcttgacg   791340
cgtttaggtt ttcattctaa gatgattgtc aatggagata ttagtcagat tgacctgcca   791400
cgtaatgtca agtccggttt gattgatgct caagagaaac tcaagaacat ccatcagatt   791460
gactttgttc atttttcagc caaggatgtg gttcgccatc ctgttgtcgc tcagattatc   791520
cgagcctatg aatattctac tgaagttgca cacgactgat tttgaggaag ttcgcctgca   791580
aaagaataga cttgttcggt aactgtaaaa agtgttatac tatttttatg gaaacagtat   791640
acgacaaagc acaaaaactt aactcaaaaa acttcaaact attgattggt gtcaaaaagg   791700
aaacctttca actcatgcta gaacacctga attcagccta tcagattcag caccgaaaag   791760
gtggacgtcc acgtagtctg cccatggaag accagctcat tatgaccctc cgttacttgc   791820
gatattatcc cactcagcgt ctgctggcct ttgattttgg cgtcggtgta gctacggtaa   791880
atgccatcat cacttgggtg gaggatacac ttcgtgcgtc aggtagcttt gatttggacc   791940
atttagaagc cccgagtgct gctgtggcta ttgacgtgac cgaaagtccg attcagcgtc   792000
caaacaaaac caaagcaaaa attattctgg taaaaagaaa cgacacacct taaaaactca   792060
aattatgctg gatttgacga cacataaagt ctgtcaaatg gccttttctg acggacatac   792120
gcatgatttt actctcttca aagaaagtat tggacaaagt ttgcctgaaa cgacgcttgc   792180
ctttgttgac ctaggttatt taggcatctt gaaatttcat gagaatactt tcattcctgc   792240
taaaaattcc aaaaatcgcc gcctgagtga ggatgataag cagttaaata aagagatgtc   792300
agcgatacga attgaaattg aacattttaa cgctaaattc aagaccttcc aaatcatgtc   792360
agtcccttat cgtaaccgca gaaaacgttt cgagttacgg gcggaattaa tttgtgccat   792420
catcaattat gaagtgaact agattccgaa caagtctaat atacttttga gagaggaaaa   792480
tccagttgta taggctaaag gttttatcca aaggtctgag acaacgatta ggcacgatgg   792540
aaagaacttt tatgtggctg atgacgatca gtgcatcttc ctgtgtcata atcacagggc   792600
acaagaaagt aggaatttga aaagatgatt gaccaactat ctaagtatta cagttgtagg   792660
atactaactg aaaaggatat tccaagtatt ttatctttat atgaaagtaa tcctctgtat   792720
tttcagcatt gtccaccaga gccaaatttt gcaactgtaa aagaggacat gctttgtcta   792780
cctgaaggta aagctaaggc tgataagttt tttgttggat tttggaatgg atctgacctt   792840
gtggctgtta tggattttgt ctatgcatat cctgatgagg agactgtttt tattggtttg   792900
tttatggttg atcaagccta tcagagaaaa gggattggta gtcatattgt gacagaagca   792960
ctagcttatt ttgctaagaa ctttcgaaag gcacgtttgg cttatgttaa gggaaatccg   793020
caatctcagc atttttggga aaagcagggc tttaaatcaa ttggatgcga ggttaagcaa   793080
gaactctata cggttgttat cgctgaacag agcctagaag attagaaatg gcatcaagta   793140
agaactattt ggaatttgtt ttggaacaat tatcaggatt agatgatgtg acttaccgtt   793200
ccatgatggg ggagtatatt ctttacttcc gcggcaagat tattggcggc atttatgacg   793260
atcgcttttt agttaaaccc gtgcaagcag tcttagataa gattgaccaa tcttcttttg   793320
agtttccata caaaggtgcc aaagaaatga tttgagtgga agaacttgat aataagatgt   793380
ttctataaga cctaatttta gctatgtata accaactgcc aacgcccaaa cctaaaaaga   793440
aaaagcaagg gtgaacgaag taaaaaagaa gtctgctaag gccctgtctt tgcacgggta   793500
aaattttata tataaaaaga agctgggact aaagagctca gcttcctttg gtttatataa   793560
ttgtcattac aagacgaagt ggttgggcga aactctgttg actttattca atttagagtt   793620
tcttatgcac aattgagtct ggaacgaaag tctccagttg caaagtatac agtacaataa   793680
accaacgatg taatagctga tgacacaaag cacagtgggt aggacttgcg aagtcaccct   793740
tttcttttca aaatttatac taaatcattg atatcagtgt agtcacgatt aagtccttga   793800
gcaactggta ggttagtcaa gtaaccttga taagtagtca caccttgacg caagccttca   793860
tcttcagaga ttgcttgtgc gaatcctttg ccagccaaag cttcgatata aggaagagtg   793920
acattggtta gggcgatggt tgaagtgcga gcaaccgcac cagggatatt ggcaacggca   793980
tagtggagaa caccgtgttt ttcatagacg ggttcatcgt gcgttgtcac acggtcagct   794040
gtttcgataa cgccaccttg gtcaacagca acgtcaacga tacagagcct ggacgcattt   794100
gtttgaccat ctcatctgtc accaattccg gtgcttttgc accagggatg agaatggctc   794160
caatcaccac atcagcatct ctcacacttg cttcaatgtt gaatgaatta gacataagag   794220
tttgaatttg acttccaaag acttcttcta gaactgagag acgcttggaa ctaatatcta   794280
aaatagtcac ttgagcacca agaccaaggg cgatgcgggc agcatgtgta ccgacgacac   794340
caccaccgat gatagttact tttccttttg gaacacctgg tacaccacca agtagaacac   794400
cagagccacc agcttgctta gtaaggaagt gagctccgat ttgaacagcc atacgacctg   794460
caacctcact cataggaacg aggagcggta gttgtccttg attgtcacga acagtttcag   794520
ttgtttttgc tgttaacata gcatctgcta attctggagc agcggccatg tgcaagtagg   794580
tgaagagaag aagatcgtcg cgcaagtaac cgtattcaga acttaaagat tcttttactt   794640
tcacaaccaa ctctgctgcc caagcttcac cagcagtagc gacaatctca gctccttgct   794700
tttgatagtc agcatcagta aagccagaac cgagaccagc atttgtttcg ataaggacac   794760
gatgaccacg actaactaag ctatgaacac ctgcaggtgt gagggcgaca cggttttcgt   794820
tatttttaat ttcttttggg attccgatta acattgagat aacctacctt tcaattgacg   794880
gtcttgtttt ggttgtcaca ttccagttca taaatcaaaa atgtgacggt ttcattgtat   794940
atgaaaccgc ttcaaaaatc aagaaaaact tgtcatccaa atttttttat gctagactag   795000
tgaaaatcaa gctctaatgg agggaaaagt atggaatcaa tatttgtgaa atttgcccag   795060
tatccgtcta tagaaacgga gcgtttattg ctcagacctg taactttgga tgatgcggaa   795120
gcaatgtttg actatgcctc ggacaagggt aatacacgtt acacttttcc aaccaatcaa   795180
agcttggaag aaaccaagaa taacattgct cagttctact tggctaatcc cttgggacgt   795240
tggggaatag aactaaaaag caatggtcag tttattggaa ccattgactt gcacaagatt   795300
gattctgttc ttaagaaggc agctattggc tacattatca ataaaaagta ttggaatcaa   795360
ggattaacga cagaagccaa tcgtgctgtg attgagctag cttttgagaa gatagggatg   795420
aataagttga ctgcccttca cgataaggct aatcccgcgt caggaaaggt catggagaaa   795480
tcaggcatgc gtttttccca tgcagaacca tatgcttgta tggaccagca tgaaaaaggc   795540
cgaatcgtga caagagttca ttatgtcttg accaaggaag actattttgc aaataaataa   795600
gcagttgaaa agaaattttt cgactgtttt ttcttcctct tacgaataat ctaagagagg   795660
agaaaatatg gaagcaatta tcgagaaaat caaagagtat aaaatcatcg tcatctgtac   795720
tggtctgggc ttgcttgtag gaggattttt cctgctaaaa ccagctccac aaacacctgt   795780
caaagagacg aatttgcagg ctgaagttgc agctgtttcc aaggactcat cgaccgaaaa   795840
ggaagtgaag aaggaagaaa aggaagaacc ccttgaacaa gatctaatca cagtagatgt   795900
caaaggtgct gtcaaatcgc cagggattta tgacttgcct gtaggtagtc gagtcaatga   795960
tgctgttcag aaggctggtg gcttgacaga gcaagcagac agcaagtcgc tcaatctagc   796020
tcagaaagtt agtgatgagg ctctggttta cgttcctact aagggagaag aagcagttag   796080
tcaacagact ggttcgggga cagcttcttc aacaagcaag gaaaagaagg tcaatctcaa   796140
caaggccagt ctggaagaac tcaagcaggt caagggactg ggaggaaaac gagctcagga   796200
cattattgac catcgtgagg caaatggcaa gttcaagtca gtagacgagc tcaagaaggt   796260
ctctggcatt ggtggcaaaa caatagaaaa gcttaaagac tatgttacag tggattaaga   796320
atttctctat tcccctaatt tacctgagtt ttctattact ttggctttat tacgctattt   796380
tctcagcatc ttatcttgct ttgttgggct ttgtttttct gctagtctgt ctctttatcc   796440
aatttccgtg gaaatctgct ggtaaagttc taataatttg cggaatcttt ggattttggt   796500
ttgtttttca aaattggcaa cagagtcaag cgagtcaaaa tctggcggat tctgttgaaa   796560
gggtacggat tttgcctgat actattaagg ttaatggtga tagtctatcc tttcgtggca   796620
agtctaacgg tcgtgctttc caagtctatt ataaactcca gtccgaggag gagaaagaag   796680
cctttcaagc tttaactgac ctgcatgaga taggactaga agggaagctt tcggagccag   796740
aagggcagag aaattttggt ggctttaatt accaagccta tctgaagact cagggaattt   796800
accagactct caatatcaaa acaatccagt cacttcaaaa gattggcagt tgggatatag   796860
gagaaaactt gtccagttta cgtcgaaagg ctgtggtttg gattaagacg cactttccag   796920
accctatggg caattacatg acaggactct tgctgggaca tctggacacc gactttgagg   796980
agatgaatga gctttattcc agtctaggaa ttatccacct ctttgcccta tctggcatgc   797040
aggtaggttt tttcatgaat ggatttaaga aacttctctt gcgattgggc ttgacccaag   797100
aaaagttgaa atggctgact tatccctttt cccttatcta tgcgggacta actggatttt   797160
cagcatcggt tattcgcagt ctcttgcaaa agctactggc tcaacatggg gttaagggct   797220
tggataattt tgccttgacg gtgcttgtcc tctttattgt catgccaaac tttttcttga   797280
cagcaggagg agtcttgtcc tgcgcttatg cttttatcct gaccatgacc agcaaagaag   797340
gggaggggct caaggctgtt actagtgaaa gtctagtcat ctccttgggc atattgccca   797400
ttctatcctt ctattttgcg gaatttcaac cttggtctat ccttttgacc tttgtctttt   797460
cctttctttt tgacttggtc ttcttaccgc tcttgtctat cttatttgtc ctttcctttc   797520
tctatccagt cattcagctg aactttatct ttgaatggtt agagggcatt attcgcttgg   797580
tctcgcaggt ggcaaggaga ccacttgtct ttggtcaacc caacgcatgg cttttaatct   797640
tattgttaat ttccttggct ttggtctatg atttgaggaa aaacattaaa ggattaacag   797700
tattgagttt attgattaca ggtctctttt tccttaccaa gtatccactg gaaaatgaaa   797760
tcaccatgct ggatgtgggg caaggagaaa gtattttcta cgggatgtaa ctgggaaaac   797820
cattctcata gatgtaggtg gtaaggcaga atcttataag aaaatcaaaa aatggcaaga   797880
aaagatgacg accagcaatg cccagcgaac cttgattccc tatctcaaaa gtcgaggagt   797940
agctaagatt gaccagctaa ttttgactaa cacggacaag gagcatgttg gagatttgtc   798000
agagatgacc aaggctttcc atgtagggga gattctagta tcaaaagaca gtctgaaaca   798060
gaaggaattt gtggcagaac tacaggcgac tcaaacaaag gtgcgtagta tgatagtagg   798120
ggagaacttg cccatttttg gaagtcagtt agaagttcta tctccaagga aaatgggaga   798180
tggaggacac gatgataccc tagttctgta tgggaaattc ttggataagc aatttctctt   798240
cacgggaaat ttggaggaga aaggagagaa ggacttgctg aagcactatc cagacttgaa   798300
agtaaatgtt ttgaaagcta gccaacatgg caataaaaaa tcatcaagtc cagcctttct   798360
agaaaaactc aaaccagagc ttactcttat ctcagttgga aagagcaatc gaatgaaact   798420
cccccatcag gaaacattga cacgactgga aggtatcaat agcaaagttt atcgaactga   798480
ccagcaagga gctatacgtt ttaaggggtt ggatagttgg aaaatcgaaa gtgttcgata   798540
ggaaggataa atgttgtaga ttagtgaaat aaactaaaaa tttgttgcat aataatgata   798600
aaaatggtat aatgaaaacg tattcaatat tgaggatata aaatcattaa aaatcagcaa   798660
aagttgtttt attagttagt ttataatcta ttggtcttct tcagtccagt gtatctgctg   798720
tgacagtcac taaaagttac aagtatgatt ggaatacggt ttgggaatat agtaccaact   798780
atcacgacca tcagtatgct tggattccgt catggtctcg ttatgacagc tattctgagt   798840
ataaagttgg cggaggctgg aactacgctc gttatgaggt cataaactat tacagcggag   798900
gctattaatt cttaaagagt gagaaaaagg agggctagat atgttgcagc ttactcatgt   798960
gaccttaaaa acgcgacaag tcatcttgca agatgtggat ttcaccttta aaaagggtag   799020
ggtttatggt cttcttgcta tcaatggctc tggaaagacg accctgttcc gtgccattag   799080
caatttaatt cccataagta gtggaaatat cgcagcccct ccttctttat tttattatga   799140
gagtattgaa tggctggatg gaaacttaag tgggatggac taccttcgtc ttatcaaaaa   799200
catctggaag tcaggtctga acttgaggga tgaaatcgcc tattgggaaa tgtctgacta   799260
tatcagtctt cccattcgca agtattcctt aggcatgaag caacgcttgg tgattgccat   799320
gtatttcctc agtcaggcca aatgctggct catggatgag attacaaatg gcttagatga   799380
gtattatcga cagaagtttt ttgataggct agcacaaatc gatagacaag aacagctggt   799440
tcttttaagt tcccactata aggaagagtt ggttgatgtc tgcgatagag tagtaaccat   799500
tcatcagggg cagatagaag aggtttagtt tatgaaagat gttagtctat ttttattgaa   799560
aaaagttttc aaaagccgct taaactggat tgtcttagct ttatttgtat ctgtactcgg   799620
tgttaccttt tatttaaata gtcagactgc aaactcacac agcttggaga gcaggttgga   799680
aagtcgcatt gcagccaacg agagggctat caatgaaaat gaagagaaac tctcccaaat   799740
gtctgatacc agctcggagg aataccagtt tgctaaaaat aatttagacg tgcaaaaaaa   799800
tcttttgacg cgaaagacag aaattctgac tttattaaaa gaagggcgct ggaaagaagc   799860
ctactatttg cagtggcaag atgaagagaa gaattatgaa tttgtatcaa atgacccgac   799920
tgctagccct ggcttaaaaa tgggggttga ccgcgaacgg aagatttacc aagccctgta   799980
tcccttgaac ataaaagcac atactttgga gtttccgacc cacgggattg atcagattgt   800040
ctggatttta gaggttatca tcccaagttt gtttgtggtt gctattattt ttatgctaac   800100
acaactattt gcagaaagat atcaaaatca tctggacaca gctcacttat atcctgtttc   800160
aaaagtgaca tttgcaatat cctctcttgg agttggagtg ggatatgtaa ctgtgctgtt   800220
tatcggaatc tgtggctttt cttttctagt gggaagtctg ataagtggtt ttggacagtt   800280
agattatccc tacccaattt atagcttagt gaatcaagaa gtaactattg ggaaaataca   800340
agatgtatta tttcctggct tgctcttagc tttcttagcc tttatcgtca ttgtggaagt   800400
tgtgtacttg attgcttact ttttcaagca aaaaatgcct gtcctctttc tttcactcat   800460
tgggattgtt ggcttattgt ttggtatcca aaccattcag cctcttcaaa ggattgcaca   800520
tctgattccc tttacttact tgcgttcagt ggagatttta tctggaagat tacctaagca   800580
gattgataat gtcgatctaa attggagcat gggaatggtc ttacttcctt gcctgattat   800640
ctttttgcta ttgggaattc tatttattga aagatgggga agttcacaga aaaaagaatt   800700
ttttaataga ttctagcttt cctataggta gggaaaataa gtaaaaacta acatagagag   800760
ggaatcaact tgattctctc tttttgattc gaaaaccaaa ccaaaataca aacacaaact   800820
tttcaaaaaa taacttttta tcttgacaag agctagaaaa cttggtatca tataaaagtt   800880
gagaaaagca gaagtgagag cttctcgcct tgtgacatta agttgcctgg ccctacggat   800940
gaaaagtttc gaagaaacgc tatcataacg tgcgggcttg tatatttaca agtccgctat   801000
tgtttttctc taataaaaca aaagaggtga aaaccatagc aaagcaagac ttattcatca   801060
atgatgagat tcgtgtacgt gaagttcgct tgattggtct tgaaggagaa cagctaggta   801120
tcaagccact cagtgaagcg caagctttgg ctgataacgc taatgttgac ctagtattga   801180
ttcaacccca agccaaaccg cctgttgcaa aaattatgga ctacggtaag ttcaaatttg   801240
agtaccagaa gaagcaaaaa gaacaacgta aaaaacaaag cgttgttact gtgaaagaag   801300
ttcgtctaag tccaacaatt gacaagggtg actttgatac aaaacttcgt aatgcacgta   801360
agttccttga aaaaggaaat aaagttaagg tatctattcg ctttaagggt cgtatgatta   801420
cccataaaga gattggtgca aaagttttag ccgagtttgc tgaagcaact caagatattg   801480
ccatcatcga acaacgtgct aaaatggatg gacgtcaaat gttcatgcaa ttggcgccag   801540
cgactgacaa aaaataattg tcagaaagtt aaataaagga gaaaaaatca tgccaaaaca   801600
aaaaacacac cgcgcatcag ctaaacgttt caaacgtaca ggttctggtg gacttaaacg   801660
tttccgtgct tacacttctc accgtttcca cggaaaaact aagaaacaac gtcgtcatct   801720
tcgtaaagca tctatggtgc attcaggaga ttacaaacgt atcaaagcaa tgcttactcg   801780
cttgaaataa tagcttgact gtaagtaaac aattctagga aatatttgga ggaaataaaa   801840
catggcacgt gttaaaggtg gcgttgtatc acgcaaacgt cgtaaacgta ttcttaaatt   801900
agcaaaaggt tactatggag ctaaacacat cttgttccgt actgcaaaag aacaagtaat   801960
gaactcttac tactatgcat accgtgaccg tcgtcagaaa aaacgtgact tccgcaaatt   802020
gtggattact cgtatcaatg cggcagctcg tatgaacgga ctttcatact cacaattgat   802080
gcatggtttg aaattggctg agatcgaagt taaccgtaaa atgcttgctg acttggctgt   802140
taacgatgca gtagctttca cagctcttgc agatgcagct aaagcaaaac ttggtaaata   802200
acaactgatg agactggaac aggattgtcc agtctttttt aaaataaagg agaaagatat   802260
ggcttcaaaa atgctacaca cttgcttacg agtagaaaat cttgaaaaat caatcgcatt   802320
ttatcaagat gcttttggtt ttaaagaatt gcgtcgcaga gattttccag accatgcctt   802380
cacgattgtc tatctaggtc ttgagggcga tgactatgag ttggagttga cttataacta   802440
cgatcacggt ccgtatgtgg ttggtgatgg gtttgcccat atcgccctca gtacacctga   802500
tcttgaggca cttcatcaag aacacagtgc aaaaggctat gaagtgactg agccaaatgg   802560
tctaccagga actacaccaa actattactt tgtcaaagac cctgatggat ataaggtcga   802620
agtcattcgt gaaaaataat ttcgtgcaag ttaagtagaa tattcgtttt ctacttgact   802680
ttttttagct gaaagagtat actaataaaa attcaacctt taaggggagt ccagagagac   802740
tcacaaggtg tcagataaaa gaatggtgca attttctaga ggagactttt tgagtgtgct   802800
ctcttgtgtt gtacgatttt aactgaggcc ttgcactagc aaggtctttt ctttatctgg   802860
tccccttaaa atttaaggag gaaaagttat gaatcccaca tgtaagaagc gtttgggtgt   802920
cattcggttg gaaaccatga aggtggttgc acaagaggaa atcgcgccag caatctttga   802980
attagtccta gaaggagaaa tggttgaagc catgcgagca ggccaatttc ttcatctgcg   803040
tgtaccggac gatgcccatc tcttacgtcg tcctatttca atttcgtcta ttgacaaggc   803100
aaacaagcag tgtcacctca tttatcggat tgacggagct gggactgcaa ttttttcaac   803160
cttaagtcag ggagacactc ttgatgtgat ggggcctcag ggaaatggtt ttgacttgtc   803220
tgaccttgat gagcagaatc aggttctcct tgttggtggt gggattggtg ttccaccctt   803280
gcttgaggtg gccaaggaat tgcatgaacg tggagtgaaa gtagtgacag tcctcggttt   803340
tgctaataag gatgctgtta ttttgaaaac ggaattggct cagtatggtc aggtctttgt   803400
aacgacagat gatggttctt atggcatcaa gggaaatgtt tccgttgtta tcaatgattt   803460
agacagtcag tttgatgctg tttactcgtg tggggctcca ggaatgatga agtatatcaa   803520
tcaaaccttt gatgatcacc caagagccta tttatctctg gaatctcgta tggcttgtgg   803580
gatgggagct tgctatgcct gtgttctaaa agtaccagaa aacgagacgg tcagccaacg   803640
cgtctgtgaa gatggtcctg ttttccgcac aggaacagtt gtattataag gagaaaatta   803700
tgactacaaa tcgattacaa gtttctctac ctggtttgga tttgaaaaat ccgattattc   803760
cagcatcagg ctgttttggc tttggacaag agtatgccaa gtactatgat ttagaccttt   803820
taggttctat tatgatcaag gcgacaaccc ttgaaccacg ttttgggaat ccaactccaa   803880
gagtggcaga gacgcctgct ggtatgctca atgcaattgg cttgcaaaat cctggtttag   803940
aggttgtttt ggctgaaaag ctaccttggc tggaaagaga atatccaaat cttcctatta   804000
ttgccaatgt agctggtttt tcaaaacaag agtatgcagc tgtttctcat gggatttcca   804060
aggcaactaa tgtaaaagct atcgagctca atatttcttg tcccaatgtt gaccactgta   804120
atcatggact tttgattggt caagatccag atttggctta tgatgtggtg aaagcagctg   804180
tggaagcctc agaagtgcca gtttatgtca aattaacccc gagtgtgacc gatatcgtta   804240
ctgtcgcaaa agctgcagaa gatgcgggag caagtggctt gaccatgatc aatactctgg   804300
ttggaatgcg ctttgacctc aaaactagaa aaccaatctt ggccaatgga acaggtggaa   804360
tgtctggtcc agcagtcttt ccagtagccc tcaaactcat ccgccaagtt gcccaaacaa   804420
cagacctgcc tatcattgga atgggaggag tggattcggc tgaagctgcc ctagaaatgt   804480
atctggctgg ggcatctgct atcggagttg gaacagctaa ctttaccaat ccttatgcct   804540
gccctgacat catcgaaaat ttaccaaaag tcatggataa atacggtatt agcagtctgg   804600
aagaactccg tcaggaagta aaagagtctc tgaggtaaac tgcaatcaat ctgttcttga   804660
ttttttatta gtttgtaata tgaatttagg agaattttgg tacaataaaa taaataagaa   804720
cagaggaaga aggttaatga agaaagtaag atttattttt ttagctctgc tatttttctt   804780
agctagtcca gagggtgcaa tggctagtga tggtacttgg caaggaaaac agtatctgaa   804840
agaagatggc agtcaagcag caaatgagtg ggtttttgat actcattatc aatcttggtt   804900
ctatataaaa gcagatgcta actatgctga aaatgaatgg ctaaagcaag gtgacgacta   804960
tttttacctc aaatctggtg gctatatggc caaatcagaa tgggtagaag acaagggagc   805020
cttttattat cttgaccaag atggaaagat gaaaagaaat gcttgggtag gaacttccta   805080
tgttggtgca acaggtgcca aagtaataga agactgggtc tatgattctc aatacgatgc   805140
ttggttttat atcaaagcag atggacagca cgcagagaaa gaatggctcc aaattaaagg   805200
gaaggactat tatttcaaat ccggtggtta tctactgaca agtcagtgga ttaatcaagc   805260
ttatgtgaat gctagtggtg ccaaagtaca gcaaggttgg ctttttgaca aacaatacca   805320
atcttggttt tacatcaaag aaaatggaaa ctatgctgat aaagaatgga ttttcgagaa   805380
tggtcactat tattatctaa aatccggtgg ctacatggca gccaatgaat ggatttggga   805440
taaggaatct tggttttatc tcaaatttga tgggaaaatg gctgaaaaag aatgggtcta   805500
cgattctcat agtcaagctt ggtactactt caaatccggt ggttacatga cagccaatga   805560
atggatttgg gataaggaat cttggtttta tctcaaatct gatgggaaaa tagctgaaaa   805620
agaatgggtc tacgattctc atagtcaagc ttggtactac ttcaaatccg gtggttacat   805680
gacagccaat gaatggattt gggataagga atcttggttt tacctcaaat ctgatgggaa   805740
aatagctgaa aaagaatggg tctacgattc tcatagtcaa gcttggtact acttcaaatc   805800
tggtggctac atggcgaaaa atgagacagt agatggttat cagcttggaa gcgatggtaa   805860
atggcttgga ggaaaaacta caaatgaaaa tgctgcttac tatcaagtag tgcctgttac   805920
agccaatgtt tatgattcag atggtgaaaa gctttcctat atatcgcaag gtagtgtcgt   805980
atggctagat aaggatagaa aaagtgatga caagcgcttg gctattacta tttctggttt   806040
gtcaggctat atgaaaacag aagatttaca agcgctagat gctagtaagg actttatccc   806100
ttattatgag agtgatggcc accgttttta tcactatgtg gctcagaatg ctagtatccc   806160
agtagcttct catctttctg atatggaagt aggcaagaaa tattattcgg cagatggcct   806220
gcattttgat ggttttaagc ttgagaatcc cttccttttc aaagatttaa cagaggctac   806280
aaactacagt gctgaagaat tggataaggt atttagtttg ctaaacatta acaatagcct   806340
tttggagaac aagggcgcta cttttaagga agccgaagaa cattaccata tcaatgctct   806400
ttatctcctt gcccatagtg ccctagaaag taactgggga agaagtaaaa ttgccaaaga   806460
taagaataat ttctttggca ttacagccta tgatacgacc ccttaccttt ctgctaagac   806520
atttgatgat gtggataagg gaattttagg tgcaaccaag tggattaagg aaaattatat   806580
cgatagggga agaactttcc ttggaaacaa ggcttctggt atgaatgtgg aatatgcttc   806640
agacccttat tggggcgaaa aaattgctag tgtgatgatg aaaatcaatg agaagctagg   806700
tggcaaagat tagtactata agtgaatatg atttgagtga atagtaagtt aaaaatcctg   806760
atttcaagta aaatcaggat tttttcatgg atgcaatttt tttggagtct ggtgtgacgc   806820
ggagggtctt ttgtcctgtg taagtgacaa agccgggttt tccaccagtt ggtttattga   806880
gttttttgac ttcaatcata tctacctgca ccagattcga caggcgccct tgagagaagt   806940
aggcagctaa ctctgctgcg tctgtcttga ctgcatcaga tgggtcaaga tttcctgaga   807000
tgacaacatg gcttccagga atgtccttag catggaacca aagttcctcc ttgcgggcca   807060
ttttaaaggt caattcctca ttttgaagat tgtttcgtcc gacatagatg atggttttgc   807120
catcgcttgc tagatattgt tctagttttt tgcgtttctg gattttctcc cgttgtcttc   807180
tgcggataaa acctgtttga atcaattctt cacggatttc agcgatttct tccagtccag   807240
cttggttgag gacggtttct acactttcca gatagagaat agtggctttg gtttcttcaa   807300
tcaaatcagt caagtatttg acagcttctt tgagtttctg ataccgttta aaatagcgtt   807360
gggcattctg gttgggagtc agagccttat caagcgcaat catgataggt tggttggtat   807420
agtagttgtc taggataacc tggtcttggt cgttaggcac ttggtggagg aaggttgtca   807480
gcaattctcc tttttgacga aattcttcag cgttgtctgt cgccagtaac tctttttcct   807540
gttttttgag tttgtgtcgg tttttctgaa gttcattttc aacacgacga atcagttcac   807600
tggcctgctg tttgacgcgg tcgcgctcag ccttatcctt atagtaggtg tccaacaaat   807660
cagaaagatt tgcaaaaggc tctcccacct gatttgcaaa aggaactgga ctgaaggaag   807720
tctcagtcaa gcatggcttg gtttcttgat tgaaaaaatt tcggaaagcg gaaagttttt   807780
cactaaccag tatcctttcc aattcatttg ccgtatcgcg tcccagacct tgaaagaggc   807840
tttgaagatt ttttgctgtt agttcttggg tttgcaggat ttcaaagagc ttttcatcct   807900
tgatagtaaa aggattgaga gattttgtac ttggcggagc gatataggtc gatcctggaa   807960
gtaaggtgcg gtagctattt tgtgaaaagc cgacgtgttt gataacttcg aggattttat   808020
gactgctttt atcgaccagt agaatattac tgtgtttccc cataatttcg ataatcaagg   808080
tagcctggat atggtctcca atctcgtttt tattggaaac tgtaatttcc acaatacggt   808140
cattttccac ttgctcaatc gactcaatca gggccccctg caaatacttt ctcaaaacca   808200
tgataaaggt agaaggttga gctggatttt caaaagtcgt ttgggtcagc tgaatgcgtc   808260
caaaaactgg atgggcagaa aggagcaggc gatggctttg gcgattgctg cggatttgca   808320
agaccaactc ttgttcaaaa ggctgattga ttttctggat gcgaccattc actaattcgc   808380
ttcgcaattc ctcaactatg tggtgtaaaa aaaatccgtc aaatgacatc gttctctcct   808440
tgtgattgta ttccatagta ttatatcaaa aaggtagaat aaaatcatgg aaatgtggta   808500
taataaagcc aagtaaagag aaacgagaag cacatgtata ttgaaatggt agatgaaact   808560
ggtcaagttt caaaagaaat gttgcaacaa acccaagaaa ttttggaatt tgcagcccaa   808620
aaattaggaa aagaagacaa ggagatggca gtcacttttg tgaccaatga gcgtagtcat   808680
gaacttaatc tggagtaccg taacaccgac cgtccgacag atgtcatcag ccttgagtat   808740
aaaccagaat tggaaattgc ctttgacgaa gaggatttgc ttgaaaattc agaattggca   808800
gagatgatgt ctgagtttga tgcctatatt ggggaattgt tcatctctat cgataaggct   808860
catgagcagg ccgaagaata tggtcacagc tttgagcgtg agatgggctt cttggcagta   808920
cacggctttt tacatattaa cggctatgat cactacactc cggaagaaga agcggagatg   808980
ttcggtttac aagaagaaat tttgacagcc tatggactca caagacaata aacgaaaatg   809040
gaaaaatcgt gacttgatat ccagtttaga atttgctttg acaggtattt ttactgctat   809100
caaggaagaa cgcaatatgc gaaaacacgc agtgacggct ctagtggtca tccttgcagg   809160
ttttgttttt caggtgtcac gaatcgaatg gctctttctc ctattgagta ttttcttggt   809220
agtagccttt gagattatca actctgctat tgaaaatgtg gtggatttgg ccagtcacta   809280
tcacttttcc atgctggcta aaaatgccaa ggatatggcg gccggcgcgg tattagtggt   809340
ttctcttttc gcagccttaa caggcgcatt gatttttctc ccacgaatct gggatttatt   809400
attttaaaca gtaagaggaa attatgactt ttaaatcagg ctttgtagcc attttaggac   809460
gtcccaatgt tgggaagtca acctttttaa atcacgttat ggggcaaaag attgccatca   809520
tgagtgacaa ggcgcagaca acgcgcaata aaatcatggg aatttacacg actgataagg   809580
agcaaattgt ctttatcgac acaccaggga ttcacaagcc taaaacagct ctcggagatt   809640
tcatggttga gtctgcctac agtacccttc gcgaagtgga cactgttctt ttcatggtgc   809700
ctgctgatga agcgcgtggt aagggggacg atatgattat cgagcgtctc aaggctgcca   809760
aggttcctgt gattttggtg gtgaataaaa tcgataaggt ccatccagac cagctcttgt   809820
ctcagattga tgacttccgt aatcaaatgg actttaagga aattgttcca atctcagccc   809880
ttcagggaaa taacgtgtct cgtctagtgg atattttgag tgaaaatctg gatgaaggtt   809940
tccaatattt cccgtctgat caaatcacag accatccaga acgtttcttg gtttcagaaa   810000
tggttcgcga gaaagtcttg cacctaactc gtgaagagat tccgcattct gtagcagtag   810060
ttgttgactc tatgaaacga gacgaagaga cagacaaggt tcacatccgt gcaaccatca   810120
tggtcgagcg cgatagccaa aaagggatta tcatcggtaa aggtggcgct atgcttaaga   810180
aaatcggtag catggcccgt cgtgatatcg aactcatgct aggagacaag gtcttcctag   810240
aaacctgggt caaggtcaag aaaaactggc gcgataaaaa gctagatttg gctgactttg   810300
gctataatga aagagaatac taagtagagg taggctcatg cctgcttctt gtttttacag   810360
aaggaggact tatgcctgaa ttacctgagg ttgaaaccgt ttgtcgtggc ttagaaaaat   810420
tgattatagg aaagaagatt tcgagtatag aaattcgcta ccccaagatg attaagacgg   810480
atttggaaga gtttcaaagg gaattgccta gtcagattat cgagtcaatg ggacgtcgtg   810540
gaaaatattt gcttttttat ctgacagaca aggtcttgat ttcccatttg cggatggagg   810600
gcaagtattt ttactatcca gaccaaggac ctgaacgcaa gcatgcccat gttttctttc   810660
attttgaaga tggtggcacg cttgtttatg aggatgttcg caagtttgga accatggaac   810720
tcttggtgcc tgacctttta gacgtctact ttatttctaa aaaattaggt cctgaaccaa   810780
gcgaacaaga ctttgattta caggtctttc aatctgccct tgccaagtcc aaaaagccta   810840
tcaaatccca tctcctagac cagaccttgg tagctggact tggcaatatc tatgtggatg   810900
aggttctctg gcgagctcag gttcatccag ctagaccttc ccagactttg acagcagaag   810960
aagcgactgc cattcatgac cagaccattg ctgttttggg ccaggctgtt gaaaaaggtg   811020
gctccaccat tcggacttat accaatgcct ttggggaaga tggaagcatg caggactttc   811080
atcaggtcta tgataagact ggtcaagaat gtgtacgctg tggtaccatc attgagaaaa   811140
ttcaactagg cggacgtgga acccactttt gtccaaactg tcaaaggagg gactgatggg   811200
aaaaatcatc ggaatcactg ggggaattgc ctctggtaag tcaactgtga caaattttct   811260
aagacagcaa ggctttcaag tagtggatgc cgacgcagtc gtccaccaac tacagaaacc   811320
tggtggtcgt ctgtttgagg ctctagtaca gcactttggg caagaaatca ttcttgaaaa   811380
cggagaactc aatcgccctc tcctagctag tctcatcttt tcaaatcctg atgaacgaga   811440
atggtctaag caaattcaag gggagattat ccgtgaggaa ctggctactt tgagagaaca   811500
gttggctcag acagaagaga ttttcttcat ggatattccc ctactttttg agcaggacta   811560
cagcgattgg tttgctgaga cttggttggt ctatgtggac cgagatgccc aagtggaacg   811620
cttaatgaaa agggaccagt tgtccaaaga tgaagctgag tctcgtctgg cagcccagtg   811680
gcctttagaa aaaaagaaag atttggccag ccaggttctt gataataatg gcaatcagaa   811740
ccagcttctt aatcaagtgc atatccttct tgagggaggt aggcaagatg acagagatta   811800
actggaagga taatctgcgc attgcctggt ttggtaattt tctgacagga gccagtattt   811860
ctttggttgt accttttatg cccatcttcg tggaaaatct aggtgtaggg agtcagcaag   811920
tcgcttttta tgcaggctta gcaatttctg tctctgctat ttccgcggcg ctcttttctc   811980
ctatttgggg tattcttgct gacaaatacg gccgaaaacc catgatgatt cgggcaggtc   812040
ttgctatgac tatcactatg ggaggcttgg cctttgtccc aaatatctat tggttaatct   812100
ttcttcgttt actaaacggt gtatttgcag gttttgttcc taatgcaacg gcactgatag   812160
ccagtcaggt tccaaaggag aaatcaggct ctgccttagg tactttgtct acaggcgtag   812220
ttgcaggtac tctaactggt ccctttattg gtggctttat cgcagaatta tttggcattc   812280
gtacagtttt cttactggtt ggtagttttc tatttttagc tgctattttg actatttgct   812340
ttatcaagga agattttcaa ccagtagcca aggaaaaggc tattccaaca aaggaattat   812400
ttacctcggt taaatatccc tatcttttgc tcaatctctt tttaaccagt tttgtcatcc   812460
aattttcagc tcaatcgatt ggccctattt tggctcttta tgtacgcgac ttagggcaga   812520
cagagaatct tctttttgtc tctggtttga ttgtgtccag tatgggcttt tccagcatga   812580
tgagtgcagg agtcatgggc aagctaggtg acaaggtggg caatcatcgt ctcttggttg   812640
tcgcccagtt ttattcagtc atcatctatc tcctctgtgc caatgcctct agcccccttc   812700
aactaggact ctatcgtttc ctctttggat tgggaaccgg tgccttgatt cccggggtta   812760
atgccctact cagcaaaatg actcccaaag ccggcatttc gagggtcttt gccttcaatc   812820
aggtattctt ttatctggga ggtgttgttg gtcccatggc aggttctgca gtagcaggtc   812880
aatttggcta ccatgctgtc ttttatgcga caagcctttg tgttgccttt agttgtctct   812940
ttaacctgat tcaatttcga acattattaa aagtaaagga aatctagtgc gagtaaaaat   813000
caatctcaaa tgctcctctt gtggcagtat caattaccta accagtaaaa attcaaaaac   813060
ccatccagac aagattgagg ttttaaagta ttgtcccaag gaaagaaaag taaccctaca   813120
tcttgaatct aagtagattt tatggtaaaa taatagggat tttaaggagt ttgatatgta   813180
taacctatta ttaaccattt tattagtatt atctgttgtg attgtgattg caattttcat   813240
gcaaccaacc aaaaaccaat ccagcaatgt atttgatgcc agttcaggtg atttgtttga   813300
acgcagtaaa gctcgcggtt ttgaagctgt aatgcagcgt ttgacaggga ttttagtctt   813360
tttctggcta gccattgcct tagcattgac ggtattatca agtagataag aaaataatgg   813420
gcaggactag gtctttgcct ctttttattt ttaaaggatg tttgagaagg ttttacagta   813480
aaagaaaatt aaaaaatcta gaaagaaaat atgaaagata gaataaaaga atatttacaa   813540
gacaagggaa aggtgactgt taatgatttg gctcaggctt tgggaaaaga cagttccaag   813600
gattttcgtg agttgattaa aaccttgtcc ttaatggaaa gaaagcacca aattcgtttt   813660
gaagaagatg gtagtctgac attagaaatt aagaaaaaac atgagattac cctcaagggg   813720
atttttcatg cccataaaaa tggctttggc tttgttagtc tggaaggcga ggaggacgac   813780
ctttttgtag ggaaaaatga tgtcaactat gctattgatg gtgataccgt cgaggtagtg   813840
attaagaaag tcgctgaccg caataaggga acagcagcag aagccaaaat tattgatatc   813900
ctagaacaca gtttgacaac agttgtcggg caaatcgttc tggatcagga aaaacctaag   813960
tatgctggct atattcgttc aaaaaatcag aaaatcagtc aaccgattta tgttaagaaa   814020
ccagccctaa aattagaagg aacagaagtt ctcaaagtct ttatcgataa atacccaagc   814080
aagaaacatg atttctttgt cgcgagtgtt ctcgatgtag tgggacactc aacggatgtc   814140
ggaattgatg ttcttgaggt cttggaatca atggacattg tatccgagtt tccagaagct   814200
gttgttaagg aagcagaaag tgtgcctgat gctccgtctc aaaaggatat ggaaggtcgt   814260
ctggatctaa gagatgaaat tacctttacc attgacggtg cggatgccaa ggacttggac   814320
gatgcagtgc atatcaaggc tctgaaaaat ggcaatctgg agtttggggt tcacatcgca   814380
gatgtttctt attatgtgac cgaggggtct gcccttgaca aggaagccct taaccgtgcg   814440
acttctgttt acgtgacaga ccgagtggtg ccaatgcttc cagaacgact atcaaatggc   814500
atctgctctc tcaatcccca agttgaccgc ctgacccagt ctgctattat ggagattgat   814560
aaacatggtc gtgtggtcaa ctataccatt acacaaacag ttatcaagac cagttttcgt   814620
atgacctata gcgatgtcaa tgatatccta gctggcgatg aagaaaagag aaaagaatat   814680
cataaaattg tatcaagtat cgaactcatg gccaagcttc atgaaacttt agaaaacatg   814740
cgtgtgaaac gtggagctct caattttgat accaatgaag cgaagatttt agtggataaa   814800
caaggtaagc ctgttgatat cgttcttcgg cagcgtggta ttgccgagcg gatgattgag   814860
tcttttatgt tgatggctaa tgaaacagtt gccgaacatt tcagcaagtt ggatttgcct   814920
tttatctatc gaattcacga ggagcctaag gctgaaaagg ttcagaagtt tattgattat   814980
gcttcgagtt ttggcttgcg catttatgga actgccagtg agattagtca ggaggcactt   815040
caagacatca tgcgtgctgt tgagggagaa ccttatgcag atgtattgtc catgatgctt   815100
cttcgctcta tgcagcaggc tcgttattcg gagcacaatc acggccacta tggactagct   815160
gctgactatt atactcactt taccagtcca attcgtcgtt atccagacct tcttgttcac   815220
cgtatgattc gggattacgg ccgttctaag gaaatagcag agcattttga acaagtgatt   815280
ccagagattg cgacccagtc ttccaaccgt gaacgtcgtg ccatagaagc tgagcgtgaa   815340
gtcgaagcca tgaaaaaggc tgagtatatg gaagaatacg tgggtgaaga gtatgatgca   815400
gttgtatcaa gtattgtcaa attcggtctc tttgtcgaat tgccaaacac agttgaaggc   815460
ttgattcaca tcactaatct gcctgaattt tatcatttca atgagcgtga tttgactctt   815520
cgtggagaaa aatcaggtat cactttccga gtgggtcagc agatccgtat ccgtgttgaa   815580
agagcggata aaatgactgg agagattgat ttttcattcg tacctagtga gtttgatgtg   815640
attgaaaaag gcttgaaaca gtctagtcgt agtggcagag ggcgtgattc aaatcgtcgt   815700
tcggataaga aggaagacaa gagaaaatca ggacgctcaa atgataagcg taagcattca   815760
caaaaagaca agaagaaaaa aggaaagaaa cctttttaca aggaagtagc taagaaagga   815820
gccaagcatg gcaaagggcg agggaaaggt cgtcgcacaa aataaaaagg cacgccacga   815880
ctatacaatc gtagatacgc tagaggcagg gatggtcctg actggaactg aaatcaagag   815940
tgtacgagct gctcgaatta atctcaagga tggctttgct caagtgaaaa atggagaagt   816000
ttggctgagc aatgttcata tcgcgcctta cgaagagggc aatatctgga accaggaacc   816060
agaacgtcgt cgtaaactcc tgctccataa aaagcaaatt caaaaattgg aacaagagat   816120
caaagggaca ggaatgacct tagttcccct taaggtctat ataaaagatg gctacgctaa   816180
gcttctttta ggacttgcca aagggaagca tgactatgac aaacgggagt ctatcaaacg   816240
tcgtgagcaa aatcgagata tcgcgcgtgt gatgaaagct gttaatcagc gataaaaaga   816300
ggaattgaaa atggaaaaat tagttgccta taaacgcatg cctttgtgga ataaacaaac   816360
aatgcctgaa gctgttcagc aaaagcacaa tacaaaagtt gggacttggg ggaaaattac   816420
tgtcttgaag ggagctctca agtttattga attgacagaa gaaggggaag ttctagctga   816480
acacctcttt gaagcagggg cagacaatcc aatggcccaa cctcaagcct ggcaccgagt   816540
ggaagctgcc acagatgatg tggaatggta cttggaattt tattgtaaac ctgaggatta   816600
ttttgctaaa aaatacaata ccaatcctgt tcattcagag gtcctagagg ccatgcagac   816660
agtgaaacaa gggaaagctt tggatttggg ttgtggtcag gggcgtaatt ctctttttct   816720
agcccagcaa gattttgatg tgacggctgt agatcaaaat ggactagctc ttgaaatctt   816780
gcaaagcatt gtggagcagg aagatttgga catgcctgtt ggcctttacg atatcaattc   816840
agctagcatt gaacaagaat atgattttat cgtttcaaca gttgttctca tgtttctaca   816900
agcggaccgc attccagcta ttattcaaaa tatgcaggag aaaaccagtg ttggtggtta   816960
caaccttatc gtttgtgcca tggacacgga ggattatcct tgctcggtta acttcccatt   817020
cacctttaaa gaaggagaac tggcagacta ttacaaggat tgggaattgg ttaagtacaa   817080
tgaaaatcca ggccatttgc accgtcgcga tgagaatggc aatcgtattc aactacgctt   817140
tgcgacctta ctagctaaga aaatcaagta aacacacatg aagattagga attttcctga   817200
tcttttttct tttttacgaa tgatatagaa aaggagggaa ttcatgtttg ttgcgagaga   817260
tgctagggga gaattggtaa atgtgttaga ggataaactt gagaagcaag catacacctg   817320
cccagcttgt ggaggccagc tccatttgcg tcaaggacca agtgtacgga cgcattttgc   817380
ccataaatcc ttaaaagact gtgatttttt ctttgaaaat gaaagtccag aacacctggc   817440
caataaggaa tccctctatc actggttgaa aaaagagaca aaggttcaat tagagtaccc   817500
gctttcagaa cttaaacaga ttgcggatgt atttgtaaat ggcaatctag ctctagaagt   817560
tcagtgtagt cccttgcctc agaaagtcct taaagagcga agtgagggct atcgtagtca   817620
gggttaccaa gtactgtggt tgctgggtca aaaactgtgg ctcaaggagc gtttgactcg   817680
tctacagcaa ggttttcttt atttcagtca aaacatgggc ttttatgttt gggaattaga   817740
caaggaaaaa caagttttaa gactcaaata cctgatttac caggatctcc gcggtaaact   817800
ccattatcaa atcaaggaat tttcctatgg tcaaggtagt ttattggaaa tattgcgtct   817860
tccctataag agacaaaaaa tatctcattt tacagtttct gaggacaagg acatctgtcg   817920
ctatatccgg caacaacttt attatcaaaa tctcttttgg atgaaagaac aagcagaagc   817980
ctatcaaaag ggagaaaata tcctgactta tggactgaaa gaatggtatc cacaaattcg   818040
accaatagtg ggcaaatttt tccagattga acaagacttg actagctatt atcagcactt   818100
ttatacctat taccaaaaaa atcctcaaaa tgattggcaa aagctttatc caccagcctt   818160
ttatcagcaa tatttcttga aaaatatggt agaatagaaa ggatggagga atctaatggt   818220
attacaaaga aatgaaataa atgaaaaaga tacatgggat ctatcaacga tctacccaac   818280
tgaccaggct tgggaagaag ccttaaaaga tttaacagaa caattggaga cagtagccca   818340
gtatgaaggc catctcttgg atagtgcgga taacctacta gaaatcactg aattttctct   818400
tgaaatggaa cgccagatag agaagcttta cgcttatgct catatgaaga atgaccagga   818460
tacacgtgaa gctaagtatc aagagtacta tgccaaggcc atgacactct acagccagtt   818520
agaccaagcc ttttcattct atgagcctga atttatggag attagcgaaa agcagtatgc   818580
tgacttttta gaagctcaac caaagctgca ggtttatcaa cactattttg acaagctttt   818640
gcaaggcaag gatcacgttc tttcacaacg tgaagaagaa ttattggctg gagctggaga   818700
aatctttggt tcagcaagtg aaaccttcgc tatcttggac aatgcggata ttgtgttccc   818760
ttatgtccta gacgatgatg gtaaagaagt tcagctatct catgggactt acacacgttt   818820
gatggagtct aaaaaacgtg aggttcgccg tggtgcctat caagctcttt atgcgactta   818880
cgaacaattc caacacacct atgccaaaac cttgcaaacc aatgttaagg tgcaaaatta   818940
ccgtgctaaa gttcgtaact acaagagtgc tcgtcatgca gccctcgcag cgaattttgt   819000
tccagaaagt gtttatgaca atttggtagc agcagttcgc aagcatttgc cactcttaca   819060
tcgctatctt gagcttcgtt caaaaatctt ggggatttca gatctcaaga tgtacgatgt   819120
ctacacaccg ctttcatctg ttgaatacag ttttacctac caagaagcct tgaaaaaagc   819180
agaagatgct ttggcagtct tgggtgagga ttacttgagc cgtgttaaac gtgccttcag   819240
cgagcgttgg attgatgttt acgaaaatca aggcaagcgt tcaggtgcct actctggtgg   819300
ttcttatgat accaatgcct ttatgcttct caactggcaa gacaatctgg acaatctctt   819360
tactcttgtt catgaaacag gtcacagtat gcattcaagc tatactcgtg aaactcagcc   819420
ttatgtttac ggggattact ctatcttttt ggctgagatt gcctcaacta ccaatgaaaa   819480
tatcttgacg gagaaattat tggaagaagt ggaagacgac gcaacacgct ttgctattct   819540
caataacttc ctagatggtt tccgtggaac agttttccgc caaactcaat ttgctgagtt   819600
tgaacacgcc attcaccaag cagatcaaaa tggggaggtc ttgacaagcg atttcctaaa   819660
taaactctac gcagacttga accaagagta ttatggtttg agtaaggaag acaatcctga   819720
aatccaatac gagtgggctc gcattccaca cttctactat aactactatg tatatcaata   819780
ttcaactggc tttgcggccg cctcagcctt ggctgaaaaa attgtccatg gtagtcaaga   819840
agaccgtgac cgctatatcg actacctcaa ggcaggtaag tcggactatc cacttaatgt   819900
catgagaaaa gctggtgttg atatggagaa ggaagactac ctcaacgatg cctttgcagt   819960
ctttgaacgc cgtttaaatg agtttgaagc ccttgttgaa aaattaggat tggcataaaa   820020
tggttgaatc gtatagtaag aatgctaacc ataacatgcg tcgtcctgtc gtcaaagaag   820080
aaattgtaga cttgatgcgt cagcgtcaaa agcaggtcac aggtttcttg aaagaattgg   820140
aagactttgc ccgcaaggaa aatattccta ttattcccca tgaaacggtt gcttatttcc   820200
gttttcttat ggaaaccatg cagcctaaaa atattctgga aattgggacg gctatcggtt   820260
tttcagctct cttgatggct gaacatgcgc caaatgctaa gattacaact attgatcgta   820320
atccagaaat gattggtttt gccaaggaaa attttgccca gtttgacagt cgcaagcaaa   820380
tcactctcct agagggagat gcggtggatg tcttatctac actgacagag tcttatgatt   820440
tcgtctttat ggattctgcc aagtctaaat acatcgtctt tctgccagaa atcctcaaac   820500
atttggaagt tggtggtgtg gttgtcttgg atgatatttt tcaaggtggt gatgttgcca   820560
aggatattat ggaagtccgt cgtggtcagc gaaccattta tcgaggcctt caaaaattat   820620
ttgatgcaac cttagacaat ccagaactca ccgcaacatt agtgccttta ggagatggta   820680
ttctcatgct tcgtaaaaat gtagcagatg ttcaactgtc tgaaagcgaa tgattttcag   820740
aaaaatttaa gaaaaaatag taaaatagat agagtaacac ttatctcaaa ggagtagaca   820800
tgaagaaaaa attattggca ggtgccatca cactattatc agtagcaact ttagcagctt   820860
gttcgaaagg gtcagaaggt gcagacctta tcagcatgaa aggggatgtc attacagaac   820920
atcaatttta tgagcaagtg aaaagcaacc cttcagccca acaagtcttg ttaaatatga   820980
ccatccaaaa agtttttgaa aaacaatatg gctcagagct tgatgataaa gaggttgatg   821040
atactattgc cgaagaaaaa aaacaatatg gcgaaaacta ccaacgtgtc ttgtcacaag   821100
caggtatgac tcttgaaaca cgtaaagctc aaattcgtac aagtaaatta gttgagttgg   821160
cagttaagaa ggtagcagaa gctgaattga cagatgaagc ctataagaaa gcctttgatg   821220
agtacactcc agatgtaacg gctcaaatca tccgtcttaa taatgaagat aaggccaaag   821280
aagttctcga aaaagccaag gcagaaggtg ctgattttgc tcaattagcc aaagataatt   821340
caactgatga aaaaacaaaa gaaaatggtg gagaaattac ctttgattct gcttcaacag   821400
aagtacctga gcaagtcaaa aaagccgctt tcgctttaga tgtggatggt gtttctgatg   821460
tgattacagc aactggcaca caagcctaca gtagccaata ttacattgta aaactcacta   821520
agaaaacaga aaaatcatct aatattgatg actacaaaga aaaattaaaa actgttatct   821580
tgactcaaaa acaaaatgat tcaacatttg ttcaaagcat tatcggaaaa gaattgcaag   821640
cagccaatat caaggttaag gaccaagcct tccaaaatat ctttacccaa tatatcggtg   821700
gtggagattc aagctcaagc agtagtacat caaacgaata gtccaaatca atgagtcagg   821760
gaaaaaactc gacttcagga aaaaatgaag caaacattcc cacaataaaa cgcatagtac   821820
aaggtttgta ctgcccccca aaaagttaga caattaattt atccgaagga tttagttctg   821880
tattgcacag agctaagtcc ttttagtttt atcttaattc tcttattgtt gtaataatca   821940
atatagtcta taatggctcg ttccaattga ttaagtgatt taaatgtttt ctcatagcca   822000
taaaacattt cggattttaa aatgccaaag aaagattcca tcctaccgtt gtcttggctg   822060
ttgcccttac gtgacatgga tgcttgaatt cccttactct ctaggaagcg atgataagaa   822120
tcgtgttgat attgccagcc ttggtcacta tggagaatcg tattctcgta gtgcttctct   822180
ttgaatgcct gttccaacat taacgatcaa tcaatttaat catgtaccta agattagaat   822240
tgtttatccc aaatttattt gaaagcttct ctaagctata tccttgtttt ctaagttcat   822300
agatctgaac tttatcatca taagttaatt tcataataaa aacaccccaa aagttagatt   822360
ttttctgtct aacttttggg gtgtagttca tgtacacctg atatgatgcg ttttataatt   822420
ttaaagactt tttgaccagc ctcatttttt taacttgata ctcagtgaaa agcaaagatt   822480
aaactaggaa gctagctgta ggctgctcaa agaacagctt tgaggttgta gataaaactt   822540
gtgaggtcac caacatatat aatgtgaagc tgacgtggtt tgaatagatt ttagaagagt   822600
atgagtctgg aagttttaat ggataatgca agattccata gaatgggtaa gctagagttc   822660
ttatgtgaag agtttgggca taaactttta ccttttcctc cctactcatc ttagtataga   822720
aaagtgaatc tgaaatagta cataactgct tctaaaacat tcttataaat tgatttaaat   822780
tctcaaatca tattattcag ttcttatttc attttgttct acaatcctgt tgagaagaca   822840
cgtgttcata tcaaaaaggt attggcaagt tgcaatacct ttttacgagg ctctgttgtc   822900
ttatttttgt ttcaactgac tatatctcct atggttctag ttcagaaggc taggctataa   822960
ttatgattga taagaagtat cattccaagt attgggagtg aatgtttcaa aatcatgggt   823020
ttctataatg gtcaggctgg catttgctag accgccatct ttacgaagaa gtggttcttt   823080
atagcctagg agagtacgaa gactggcagt aagattggcg ccgtgtccga caattagaat   823140
acgttcagct ggactatctt ttaatgattt gataaattgg atggtccgtt gagttgtact   823200
atagagggat tcggctccga acattcgagt gtcaaattga gcaagatttg aacgaaaagc   823260
ctggatttgt tgcgggtaaa tagcttccaa ggttgcaatt ttcaaacctt ctaacttccc   823320
aagttgccat tcacggagat taggaacgat ttctaaagaa cagggggtat agagttgact   823380
ttggataatc tcagcagatt tgaccgctcg aggtaaatca cttgaataaa tctgatcaaa   823440
aggaatttcc ttgagatact gaccaagtcg ttttagggtt tcaatggatt caggaagaag   823500
aggagaatca ccactagcac cttgaaaacg accttcttgg ttccagaggg tacgaccgtg   823560
gcggacaaag tagagtttca ttacttgatg tcctccaaaa tatctacaaa gtctgccttt   823620
acaaagctag ccaagtcttg tggcgcgacg ataatgctgt gtccgacttc gcctgcagag   823680
acaatcattt gatccaaatc tagagcaatt ttatcgataa aaatgggata attgtgtttc   823740
tgacgaattc cgacaggatt attggctcca tgaatgtaac cagttgtttt ttctaagtcc   823800
ttttgtggaa tcatgctcac ttttttattg ccagaaattt tagctagttt cttttcagac   823860
aagtgctgag tgatagggac aattccgata atcggtccgg tcttgtctcc caaaagcgcc   823920
aaggttttga aaatctgatc tcgttcataa ccttgaggaa gctctccttc tagggcattg   823980
atttgaatcc cctgatgagg gatagctgct ttagatagga tttgttccac caatgttttt   824040
ttgattttaa ctttttttgc cattatttat atttatcctc caattgactc atccaaatac   824100
caagccagat tcccagcgca aagaagaagg cgatgatgac ataaccgaca agtgaaagtc   824160
ctgtgtattg gatactttca gcgtttcctg catttggaat taagatcaaa agggtacttg   824220
ataggacgat accgatgatg aaatgataga cgcgtgagtg gtagttgttt aaggcataat   824280
ctatcaattt tgaaaaaacg atgagagttg cacctgcacc aattccaatc ggaaagaagg   824340
ttcccaagaa atcaaaagtt ttaaaaccag tcaacatagg agcatagagt cccaaaatca   824400
aaagtaaatt tgatgggctg aggccaggaa ccaagacgcc aagggccaat agtgcgcctg   824460
ctaggacgaa gttaagaaag ctggcgctta aggttccaac gacaaaattt aaggcataga   824520
gtcctaatcc agaaatgata aaggttgtcc ataaccaagc taaatcaatc ttgtctcggt   824580
cagattctcg agttgattct ttgaggaggc taggaactgt accgataata gctcccgcaa   824640
agctccataa tacaaaaacc tgataatttt caagcaggta ttcaatcggg taggaaaata   824700
agccgattcc cagaagcata ccgatggcaa ctggaataaa gtacaaaaca ttttctttaa   824760
agtctttaaa gggatgggcc agaaagccaa tcattcgttc atagattcct aagattgctg   824820
ctagaacccc tccggaaatt cccggtagga taaatccaag agcaattaca atccctttaa   824880
taacgcgtgc taaccatgag agcatatatt tcctccaact atttctattt caaaaaatcc   824940
ttactatatt gtatcacaat cagacacaaa aagaaaaagc aaatgataaa caaatgcttt   825000
taaggtttta aaaaaagttt tcgaaaggtt tcttctttat tttttaaggg agagataacg   825060
ttgatatcta aatcgtggtc aaagccggca atttttcctt tagatgtgta ttggtgaata   825120
tcataatcta aatcagtttt aggactgctc tccaaaaatc ctgagtctga gccgtaggac   825180
ggaatccaaa cagaggtaaa cttgcctgta tcaatactgt gttcttccat gaagtagaca   825240
ccaacgtaga tgccgatgtt tttagcaccc agtgatgcta gttttgctcg aaagttttcg   825300
acaccttcgt tcatattaga catggttttg tcttccacgt caagccaata gtaactaggg   825360
ctgtaaggag aggcagcatt gtagaaaact tcggcagcct tttccatttc ttggacactt   825420
tttccagcta cataagcgta gacagcaact gggacattcc gcttttgaag ttcagtgata   825480
tgactcttat aggccttgtc tattccattg ataaatgaag catcattttc ttttgtcgtt   825540
tgagcaccac tgtgaacacg aacaatagca cctgaaatat tttgtgagag ggcatcgtag   825600
ttgatttcct caggacgctg ccagccagag aggtcaataa tcggtttgtc taagtgtttc   825660
aaagcctgtg cttcaatctg tgctatattg gattttgttt taaacgattg gctgtcatta   825720
agtgggcgat tgatgattaa aatgaacatc ataatcccaa aaaaactaaa taaaataagt   825780
ggatgaattt gttttctcat atcttataat tctaccctaa aaatcaaaaa aaatcaaaaa   825840
aatgggttaa ggaagagact ttagagcatt ttttcattca agagtgcgga atgatttgaa   825900
atatggtata ataaaaggga atttctacag aaaagagaag attatgtcaa attttgccat   825960
tattttagca gcgggtaaag ggactcgcat gaaatctgat ttgccaaaag ttttgcacaa   826020
ggttgcgggt atttctatgt tggaacatgt tttccgtagt gtgggagcta tccaacctga   826080
aaagacagta acagttgtag gacacaaggc agaattggtt gaggaggtct tggctggaca   826140
gacagaattt gtgactcaat ctgaacagtt gggaactggt catgcagtta tgatgacaga   826200
gcctatctta gaaggtttgt caggacacac cttggtcatt gcaggagata ctcctttaat   826260
cactggtgaa agcttgaaaa acttgattga tttccatatc aatcataaaa atgtggccac   826320
tatcttgact gctgaaacgg ataatccttt tggttatgga cgaattgttc gtaatgacaa   826380
tgctgaggtt cttcgtattg ttgagcagaa ggatgctaca gattttgaaa agcaaatcaa   826440
ggaaatcaac actggaacat acgtctttga caacgagcgt ttgtttgagg ctttgaaaaa   826500
tatcaatacc aataacgctc aaggcgaata ctatattaca gacgtcattg gtattttccg   826560
tgaaactggt gaaaaagttg gcgcttatac tttgaaagat tttgatgaaa gtcttggggt   826620
aaatgaccgt gtggcgcttg cgacagctga gtcagttatg cgtcgtcgca tcaatcataa   826680
acacatggtc aacggtgtta gctttgtcaa tccagaagca acttatatcg atattgatgt   826740
tgagattgct tcggaagttc aaatcgaagc caatgttacc ttgaaagggc aaacgaaaat   826800
tggtgctgag actgttttga caaacggtac ttatgtagtg gacagcacta tcggagcagg   826860
agcggtcatt accaattcta tgattgagga aagtagtgtt gcagacggtg tgatagtcgg   826920
tccttatgct cacattcgtc caaattcaag tctgggtgcc caagttcata ttggtaactt   826980
tgttgaggtg aaaggatctt caatcggtga gaataccaag gctggtcatt tgacttatat   827040
cggaaactgt gaagtgggaa gcaacgttaa tttcggtgct ggaactatta cagtcaacta   827100
tgacggcaaa aacaaataca agacagtcat tggaaacaat gtctttgttg gttcaaattc   827160
aaccattatt gcaccagtag aacttggtga caattccctc gttggtgctg gttcaactat   827220
tactaaagac gtgccagcag atgctattgc tattggtcgc ggtcgtcaga tcaataaaga   827280
cgaatatgca acacgtcttc ctcatcatcc taagaaccag taggagccta tcatggagtt   827340
tgaagaaaaa acgcttagcc gaaaagaaat ctatcaagga ccaatattta aactggtcca   827400
agatcaggtt gaattaccag aaggcaaggg aactgcccaa cgggatttga ttttccacaa   827460
tggggctgtc tgtgttttag cagtaacgga tgaacaaaaa cttatcttgg tcaagcagta   827520
ccgcaaagct atcgaggctg tctcttacga aattccagcc ggaaaattgg aagtaggaga   827580
aaacacagcc cctgtggcag ctgcccttcg tgaattagag gaagaaacag cctatacagg   827640
gaaattagaa ctcttgtacg atttttattc agctattggc ttttgtaatg agaagttaaa   827700
actatattta gcaagcgatt tgacaaaagt ggaaaatccg cgtccgcagg atgaggatga   827760
aaccttggaa gtccttgaag tgagcttaga agaagcgaaa gaattaatcc aatcaggtca   827820
tatctgtgat gccaagacaa ttatggctgt tcagtattgg gagttgcaga aaaaatagag   827880
gaggtcagta tgggtaaatc tttattaacg gatgaaatga ttgaaagagc taatagaggc   827940
gaaaaaattt caggtcctcc tttgctagat gataatgagg aaactaagat tttaccaacc   828000
tcttcttccc gttttggtta tgccaatcct aaggatcatg gttttagcca ggaaaccttg   828060
aagattcagg tcgaaccatc tattcataaa agccgtcgta ttgaaaatac caagagaaat   828120
gtcttcaatt ctaagttgaa taaaatctta tttgcggtca tctttctctt gattttgctt   828180
gttttagcaa tgaaactttt gtaatagaaa aggaattgaa atgaaaatag gaattattgc   828240
tgctatgcca gaagaactgg cttatctggt ccagcattta gataatgccc aggagcaagt   828300
tgtttttggg aatacctatc atacaggaac cattgcttct catgaagtcg ttcttgtaga   828360
aagtggaatt ggtaaggtca tgtctgctat gagtgtggcg attttggctg atcatttcca   828420
ggtggatgcc cttattaata cgggttcagc tggggcagta gcagaaggta tcgctgttgg   828480
ggatgtcgtg attgctgaca aattagccta tcatgacgtg gatgtcacag cttttggcta   828540
tgcttatgga caaatggcgc aacaaccgct ttatttcgaa tcagacaaaa cctttgttgc   828600
tcaaatccaa aagagtttat ctcaattgga ccaaaactgg catcttggtt tgattgctac   828660
aggagatagt tttgttgcag gaaatgacaa gatagaagcg attaagtccc atttcccaga   828720
agttttagcc gtggagatgg agggggcagc tattgctcaa gcagcgcatg ccctcaatct   828780
cccagtctta gtcatccgag ctatgagtga caatgccaac catgaagcaa acatcttttt   828840
tgatgagttt attatcgaag ctggacgtcg ctctgcccaa gtcttgttga cctttttgaa   828900
ggctttagat taagcggaaa tttgacagtt tttctagctt atgataagat ttaagtaaag   828960
aaaagctaga aaacgtttca gaggatatta tgagtattga aatgaccgtc agtgagattg   829020
cagaggtctt aggattatct cgccaagcaa tcaataaccg tgtcaaagaa ttaccagaag   829080
aagacacaga taaaaatgac aaaggggtaa cagttgttac cagaagtggc ttgattaagc   829140
tagaagaaat ctataaaaaa acgatttttg aagatgagcc tgtcagtgaa gatgtcaaac   829200
aacgtgaact gatggagatt ctagtggatg agaagaatgc agaaattctt cgtctttatg   829260
aacaattaaa agccaaggat cgtcagttat cagaaaaaga cgagcagatg cgtatcaaag   829320
accgtcagat tgctgagaaa gacaaacaat tagatcagca acaacaattg acccttcaag   829380
ccatgaagga tcaagaaaat cttaagctag agctggacca agcaaaagaa gaagtccaat   829440
ccactaaaaa aggctttttt gctcgtttat ttggaggata atcaaggagc tgtttaggtt   829500
aaatgctaac ctgatggctt cttttgtttg tgaatagtat agttgattag aacagagaca   829560
gtagaggaga ggtacagaat ggaacgatta gaagattaca ttgcttttga tttagaattt   829620
aatcagcacg aaggacaaac acacttgatt caagtatcgg cagtgcgttt tagagatggt   829680
cgggaaatcg atgcctatga ttcctatgtt cataccagcg tccctctaaa aagctttatc   829740
aatggtttga ccgggattac agctgagacc ttaaaagatg ctcctccagt tgagaaagtc   829800
ttagaagaat tccaagagtt tgtgggttct ttgctgatga taggctacaa tgctgctaaa   829860
agtgatttac ctattttagc agagcatggt ttagactata gccaacagta caaggtggat   829920
ttgtatgatg aagcttttga acgtcggagt tcagatttac atggtattgc caatctcaaa   829980
ttgcaaactg ttgcctcatt tcttggattt caaggtcagt ctcataatag tttagaggat   830040
gctcggatga cggcgcgtgt ttacgaatcc ttcttagagt cggatcaagc tagggaattg   830100
ttagagacag aaagtagctt atcaaacaat ccttttggtg gcttggactt gtctcaatta   830160
tttgactagg agtgcctatg aaacctgaaa aacctaaaaa attgggtctt aaacagattt   830220
acctcgatct tgataaaatc ctctttctat ttttcttgat ttttatgata gtggagtatt   830280
tgtgggtacc attcaattca tggttggcta gcttcttatt agatcagaca ggttatcttt   830340
ttatttccta taacaatgtc ttagccatcc ttactcattc tccattgatt agtctagctt   830400
ttttagcctt gattgtaatt aaccttctgg ttgcttattt tcaaatagga ctcctcttta   830460
ttggtgctcg tcatctcctc tataatgaaa agcgaaggct aattgagtat atccgcaagg   830520
ttttccatga aagttttgga tttatgaaaa agctaacttg cgctaaagcc ttgtttatct   830580
ttttctatat agctatgctg tttcctttta tacggaaaat gctgaagatt tattatctta   830640
ataaaatcgt cattccagag tttatccaag cttatttaga agatagatat tggatgtggt   830700
ggctgagcat cctacttcta tctcttatct ttctctatgt ctctgtcaga ttgatgtttg   830760
cccttccgaa gattgtatat gatcagctga ctgttcgaga agcagtgatg tttagcttgg   830820
agaaaaccaa gaagagagtt actttttatg cttggaattt attttacatc ttgctcaaag   830880
cacatttatt attttatctt cctttgattc ctttattatt ggctcaaact ttggtagatg   830940
atatcactca gagagagtct ctgattcttg gtattttgaa ttttgtcgtg attaaaaatc   831000
tctattatat ggctctgact tattttttgg ttaaatttgt ttcatttttg acaggaaagg   831060
agctggatat gcttcctagg agagaaaaag atcacatcgt gcgatggggt gtcatgactt   831120
gtgccagtct tttctttgcc ttagaaggtt atatttatct ggaggctccc atggttcatc   831180
tacctcaact tatttctcac cgaggggttt ccaatgcaaa tgggattcaa aatacagtag   831240
agtccttgga aactacagca caactcaaac cagacttggt ggagacggac gtgcaggaaa   831300
caaaagatgg gcagtttgtc atgatgcatg atgctaactt gaaaaatcta gcaggtatca   831360
ataaaagtcc tcaagactta aacttggagg agcttaaagg gattgatatt tttgaaaatg   831420
gctaccagac taaaatttca agctttgaag attatctcag tcgagccaac gaacttggtc   831480
aaaaattact aattgaaatt aaaaccagta aaaaagatag tccagacatg atgaaccgct   831540
ttttagcccg ttatgctgca aagctcaaga tttatggaca tcaaatccag tctttagact   831600
accatgttgt cgaaaaagta agacagtatg atgccgaact accagtttat ttcatcatgc   831660
cctacaattc tgtctttcct aaaacaagag cgacaggata tactatggag tactcaacct   831720
tggatgaata ttttgtaagc aaactatgga caacggatca gaaactttat gtctggactg   831780
tcaatgattc agaagctatc agcaaatctc ttcacttagg agtagatgga gtgattacag   831840
atgatttgga aaaagttcag cgggaaatag aagtagccca agaagatcca gaatatacgg   831900
atttgctctt gaaaaaagca ttggaattct ttgaatttta gtaataaaaa agaggaacgg   831960
ttgttcctcc catgataggt aagtattctt gtgaatgctt gcttttttgt ggttgcaatc   832020
cgtttacgag aattgtttgt attgttcttg tttcaattta ctttatagtg ctttgaagtt   832080
ggaatgctac actataactt ataaaatata gtaaaatgaa ccaaaaatag tacacaatgt   832140
ggtataatct tcttatggca tattcaatag attttcgtaa aaaagttctc tcttattgtg   832200
agcgaatagg tagtataaca gaagcatcac acgttttcca aatctcacgt aataccattt   832260
atggctggtt aaagctaaaa gagaaaacag gagagctaaa ccaccaagta aaaggaacaa   832320
aaccaagaaa agttgataga gatagactta aaaactatct tactgacaat ccagatgctt   832380
atttgactga aatagcttct gactttggct gtcatccaac taccatccac tatgcgctca   832440
aagctatggg ctacactcga aaaaaagaac cacacctact atgaacaaga cccagaaaaa   832500
gtagccttat ttcttaagaa ttttaatagt ttaaagcacc tagcacctgt ttagattgac   832560
gaaacaggat tcgatactta tttttatcga gaatatggtc gctcattaaa aggtcagtta   832620
ataagaggca aagtatctgg aagaagatat cagaggattt ctttggttgc aggtctaaca   832680
aatggtgaat taatcgctcc aatgacttac gaagagacga tgacgagcga cttttttgaa   832740
gcttggtttc agaagtttct cttaccaaca ttaaccacac catcggttat tatagtaaaa   832800
tgaaataaga ataggacaaa tcgatcagga cagtaaaatc gaattctaac aatgttttag   832860
aagtccatat gtactattct agtttcaata taccataact gttcctagtc aacctgcaag   832920
ccctgtccca gctccaagct cagctccgac tcaagatcct agagtggtag caagcgcttc   832980
ggctagctca acgagcacac aagctcaaga gcaagttgac aagtctgaac ttcgtgcctt   833040
gagtcaagag ttagaccaac gcttgaaagc tttggcaaca gtatctgatc cgaaaatcga   833100
tgcaaccaag gctgtcctcc tagatgctca aaaagctccg gaagatagtg ccttgacaga   833160
gtaaggtctg catactgcag tagagtctgt gaaggctggg ctgccttgga ctctctcaaa   833220
gatgtgaaag caaatgctag cgacagcaag cctgcacagg acaagaagga tgcaaaacaa   833280
ggaacggaag atagtaagga ttcagataag atgactgaaa caaactcagt tccggcagga   833340
gtgattgtgg tcagtctact tgccctccta ggcgtgattg ccttctggct gattcgccgt   833400
aagaaagagt cagaaatcca gcaattaagc acggaattga tcaaggttct aggacagcta   833460
gatgcagaaa aagcggataa aaaagtcctt gccaaagccc aaaaccttct ccaagaaacc   833520
cttgatttcg tgaaagaaga aaatggctca gcagagacag aaactaaact agtagaggag   833580
cttaaagcaa tccttgacaa actcaagtaa aacatgattt atgaaatgtc agacctaaaa   833640
gacattttcg ttcacaaaag cagcgatgag taatccttgt cgttgctttt tggctatttt   833700
gggggataag atccgccttg actagcaaaa gaaaagattg gtccaatagt gcccgatacg   833760
attttgcgta gcagaaagct tacaaataaa attgaatata gtaaaatagg attagaatta   833820
ttaagaaagt tggttcttta ttggaaacga tagtattttt aatctctgtt tttctagcag   833880
gtgttttatc ctttttttct ccttgtattt ttcctcttct gccagtctat gctgggattt   833940
tattggatga tcaagaaagt gcaaaaagct tttctttgtt tgggagaaag gttctctggt   834000
caggcttgat tcgaacactt tgctttatcg ctggtatctc tctcattttc tttattctag   834060
gctttggtgc tggttacttt ggtcatattc tctatgcaaa ttggtttcga tatggcatgg   834120
gagctattat tatcattttg ggtcttcacc agatggaaat ttttcatttg aagaaattag   834180
aagttcaaaa aagttttacc tttaaaaaat cagattctaa tcgttattgg tcagcttttt   834240
tacttggtat tacctttagc tttggttgga caccttgtat tggtccagtt ttaagttctg   834300
ttttagcact tgcggcttct ggaggcaatg gcgcttggca aggagcgatt tatactctca   834360
tttacactct gggcatggcc cttcctttct tggtattggc actagcttca ggtctagtca   834420
tgccatattt tagtaaaatc aagcgtcata tgatgctact aaagaaaatt ggtggtttcc   834480
tcattgtttt aatgggaatt ttgttactat taggacaagt aaatgttcta gctggaattt   834540
ttgaataaag gaggacaaat gaaaaaagta atgtttgctg gcttaagtct cttgtcatta   834600
gttgtattga tggcctgtgg tgaggaagaa actaaaaaga ctcaagcagc acaacagcca   834660
aaacaacaaa cgactgtaca acaaattgct gttggaaaag atgctccaga cttcacattg   834720
caatccatgg atggcaaaga agttaagtta tctgatttta agggtaaaaa ggtttacttg   834780
aagttttggg cttcatggtg tggtccatgc aagaaaagta tgccagagtt gatggaacta   834840
gcggcgaaac cagatcgtga tttcgaaatt cttactgtca ttgcaccagg aattcaaggt   834900
gaaaaaactg ttgagcaatt cccacaatgg ttccaggaac aaggatataa ggatatccca   834960
gttctttatg ataccaaagc aaccaccttc caagcttatc aaattcgaag cattcctaca   835020
gaatatttaa ttgatagcca aggaaagatt ggaaagattc aatttggtgc tatcagtaat   835080
gcggatgcag aagcagcatt taaagaaatg aactagaatc gataaaatct gattacaaga   835140
tgtagtcaga ttttggtaac ttctaaaact aacttccagt ttcccacaac ctagctttta   835200
gtatgagaaa aacgcgtgac atcagtggaa atccgtctta gactaacttc cactggtttt   835260
ctttttcttg atatataagg gttcaaaagc gaaaagactc agaaaaagtg cacgacaaat   835320
agccctaaaa cagagtcgtc ttagagtaac ttccagtttt gggagagaga tggaagttac   835380
tttgagaagt tacggtagtc agattttttt agaaaaacat tttataaata ttcacatatc   835440
tcctatattt atggtaaaat agaattatca gtttattttg gagtcaaaga tgaatatatt   835500
tagaacaaag aatgttagtt tagataaaac agagatgcat aggcatttga agttatggga   835560
tttgattttg ctgggtatcg gagccatggt agggacaggc gtctttacaa tcacaggtac   835620
tgcagctgca acacttgctg gcccagccct agtgatttca atcgttattt ctgccttgtg   835680
tgtgggatta tcagccctct tttttgcaga atttgcctcg cgagtacccg ctacaggagg   835740
tgcctatagt tacctctatg ctatcttagg agaattccct gcctggttgg ctggttggtt   835800
aaccatgatg gagttcatga cagccatatc aggcgtagct tcgggttggg cagcttattt   835860
taaaggcttg ctctctcaat acgggatagc ctttcctcag gctttaaatg gtacctttaa   835920
tcctcaagca gggacatttg ttgatttatt gcctattctt gtcttggtct tggtgacttc   835980
gcttgtttta ctaaatgcca aggcagcctt acgctttaat tcgattctag ttattttgaa   836040
attttccgct ttagctctct ttgttttagt aggaatttgg aatattaagt ttgataattg   836100
gagcaatttt gctccttacg gttttggaca aatctatgga gctagcactg gtattatggc   836160
tggtgcgtcc ttgatgttct tcggtttttt gggatttgaa tccatctcta tggctgtaga   836220
tgaagtcaag actcctcaaa aaaatattcc tagagggatt gtcttatcgc tttctatcgt   836280
aaccattctc tatgccttgg tgacccttgt tttgactggt gtggttcact atagtcattt   836340
aaatgtcgat gatgccgttg cctttgccct tcgtagtgtt gggattagtt gggcagccaa   836400
ctatgtgtca ttagtggcta tcttgacctt gattacagtt tgtatttcga tgacctatgc   836460
cctatcgcgt atgatttaca gtttagcacg tgacggctta gtgcctgctg cctttaagga   836520
actgacgaag actagcaaga taccaaagaa tgctactatc ttgacaggtc tagcttcagc   836580
agtagcagca ggaatgttcc cactagccag tattgcagcc tttttaaata tttgtacctt   836640
agcctacttg atcatgttgg cttatggtct gattcgctta cggaaagaaa aaggaatgcc   836700
caaagctggg gaatttaaaa caccattggt acctctgtta ccaattttat cgatcatcat   836760
ttgtttatcc ttcatgttac agtataatat gaatacctgg attgctttcc tagttgcgtt   836820
gttagtagga agtattattt acttcactta tggctataag cattctacca tagaagaata   836880
aagtgaaagt ctattgagtt gttgacactc agtagatttt tatatgtgaa agaaatttca   836940
aattttttct aaaaatatct tgacagatta aattttcagg agtagaatat ttactagtta   837000
attaaatggt taaggagttg ttcatgaaga aacaaaattt atttttagtc ctgttaagtg   837060
tctttctttt gtgcttgggg gcttgtggtc aaaaggaaag tcagacagga aaggggatga   837120
aaattgtgac cagtttttat cctatctacg ctatggttaa ggaagtatct ggtgacttga   837180
atgatgttcg gatgattcag tcaagtagtg gtattcactc ctttgaacct tcggcaaatg   837240
atatcgcagc catctatgat gcagatgtct ttgtttacca ttctcataca ctcgaatctt   837300
gggcaggaag tctggatcca aatctaaaaa aatccaaagt gaaggtctta gaggcttctg   837360
agggaatgac cttggaacgt gtccctggac tagaggatgt ggaagcaggg gatggagttg   837420
atgaaaaaac gctctatgac cctcacacat ggctagatcc tgaaaaagct ggagaagaag   837480
cccaaattat cgctgataaa ctttcagagg tggatagtga gcataaagag acttatcaaa   837540
aaaatgcgca agcctttatc aaaaaagctc aggaattgac taagaaattc caaccaaaat   837600
ttgaaaaagc gactcagaaa acatttgtaa cacaacatac agccttttct tatctagcga   837660
agagatttgg gcttaatcaa cttggtattg caggtatctc tcctgaacaa gaaccaagtc   837720
cacgacaact aacagaaatt caggaatttg ttaagaccta taaggttaaa acgattttta   837780
cagaaagtaa cgcttcttca aaagtagctg aaactcttgt caaatcaaca ggtgtgggtc   837840
ttaaaactct gaatccttta gagtcagacc cacaaaatga caagacctat ttagaaaatc   837900
ttgaagaaaa tatgagtatt ctagcagaag aattaaagtg aggaaagaat gaaaattaat   837960
aaaaaatatc tagcaggttc agtggcagtc cttgccctaa gtgtttgttc ctatgaactt   838020
ggtcgtcacc aagctggtca ggttaagaaa gagtctaatc gagtttctta tatagatggt   838080
gatcaggctg gtcaaaaggc agaaaacttg acaccagatg aagtcagtaa gagggagggg   838140
atcaacgccg aacaaatcgt catcaagatt acggatcaag gttatgtgac ctctcatgga   838200
gaccattatc attactataa tggcaaggtc ccttatgatg ccatcatcag tgaagagctc   838260
ctcatgaaag atccgaatta tcagttgaag gattcagaca ttgtcaatga aatcaagggt   838320
ggttatgtta tcaaggtaga tggaaaatac tatgtttacc ttaaggatgc agctcatgcg   838380
gataatattc ggacaaaaga agagattaaa cgtcagaagc aggaacacag tcataatcac   838440
gggggtggtt ctaacgatca agcagtagtt gcagccagag cccaaggacg ctatacaacg   838500
gatgatggtt atatcttcaa tgcatctgat atcattgagg acacgggtga tgcttatatc   838560
gttcctcacg gcgaccatta ccattacatt cctaagaatg agttatcagc tagcgagtta   838620
gctgctgcag aagcctattg gaatgggaag cagggatctc gtccttcttc aagttctagt   838680
tataatgcaa atccagctca accaagattg tcagagaacc acaatctgac tgtcactcca   838740
acttatcatc aaaatcaagg ggaaaacatt tcaagccttt tacgtgaatt gtatgctaaa   838800
cccttatcag aacgccatgt ggaatctgat ggccttattt tcgacccagc gcaaatcaca   838860
agtcgaaccg ccagaggtgt agctgtccct catggtaacc attaccactt tatcccttat   838920
gaacaaatgt ctgaattgga aaaacgaatt gctcgtatta ttccccttcg ttatcgttca   838980
aaccattggg taccagattc aagaccagaa caaccaagtc cacaatcgac tccggaacct   839040
agtccaagtc cgcaacctgc accaaatcct caaccagctc caagcaatcc aattgatgag   839100
aaattggtca aagaagctgt tcgaaaagta ggcgatggtt atgtctttga ggagaatgga   839160
gtttctcgtt atatcccagc caaggatctt tcagcagaaa cagcagcagg cattgatagc   839220
aaactggcca agcaggaaag tttatctcat aagctaggag ctaagaaaac tgacctccca   839280
tctagtgatc gagaatttta caataaggct tatgacttac tagcaagaat tcaccaagat   839340
ttacttgata ataaaggtcg acaagttgat tttgaggctt tggataacct gttggaacga   839400
ctcaaggatg tcccaagtga taaagtcaag ttagtggatg atattcttgc cttcttagct   839460
ccgattcgtc atccagaacg tttaggaaaa ccaaatgcgc aaattaccta cactgatgat   839520
gagattcaag tagccaagtt ggcaggcaag tacacaacag aagacggtta tatctttgat   839580
cctcgtgata taaccagtga tgagggggat gcctatgtaa ctccacatat gacccatagc   839640
cactggatta aaaaagatag tttgtctgaa gctgagagag cggcagccca ggcttatgct   839700
aaagagaaag gtttgacccc tccttcgaca gaccatcagg attcaggaaa tactgaggca   839760
aaaggagcag aagctatcta caaccgcgtg aaagcagcta agaaggtgcc acttgatcgt   839820
atgccttaca atcttcaata tactgtagaa gtcaaaaacg gtagtttaat catacctcat   839880
tatgaccatt accataacat caaatttgag tggtttgacg aaggccttta tgaggcacct   839940
aaggggtata ctcttgagga tcttttggcg actgtcaagt actatgtcga acatccaaac   840000
gaacgtccgc attcagataa tggttttggt aacgctagcg accatgttcg taaaaataag   840060
gtagaccaag acagtaaacc tgatgaagat aaggaacatg atgaagtaag tgagccaact   840120
caccctgaat ctgatgaaaa agagaatcac gctggtttaa atccttcagc agataatctt   840180
tataaaccaa gcactgatac ggaagagaca gaggaagaag ctgaagatac cacagatgag   840240
gctgaaattc ctcaagtaga gaattctgtt attaacgcta agatagcaga tgcggaggcc   840300
ttgctagaaa aagtaacaga tcctagtatt agacaaaatg ctatggagac attgactggt   840360
ctaaaaagta gtcttcttct cggaacgaaa gataataaca ctatttcagc agaagtagat   840420
agtctcttgg ctttgttaaa agaaagtcaa ccggctccta tacagtagta aaatgaatgg   840480
agcatatttt atggagaagt aacctttcgt gttacttctc ttttttagaa aaacgtaaca   840540
gaaacttgac aaaagtaatt ttaaatagta aactatttac tggttaatta aatggttaaa   840600
taaccggttt agaaaactat ttaataaagt aaaagaagtt gagaaaaaac ttcatcattt   840660
attgaaatga gggatttatg aaatttagta aaaaatatat agcagctgga tcagctgtta   840720
tcgtatcctt gagtctatgt gcctatgcac taaaccagca tcgttcgcag gaaaataagg   840780
acaataatcg tgtctcttat gtggatggca gccagtcaag tcagaaaagt gaaaacttga   840840
caccagacca ggttagccag aaagaaggaa ttcaggctga gcaaattgta atcaaaatta   840900
cagatcaggg ctatgtaacg tcacacggtg accactatca ttactataat gggaaagttc   840960
cttatgatgc cctctttagt gaagaactct tgatgaagga tccaaactat caacttaaag   841020
acgctgatat tgtcaatgaa gtcaagggtg gttatatcat caaggtcgat ggaaaatatt   841080
atgtctacct gaaagatgca gctcatgctg ataatgttcg aactaaagat gaaatcaatc   841140
gtcaaaaaca agaacatgtc aaagataatg agaaggttaa ctctaatgtt gctgtagcaa   841200
ggtctcaggg acgatatacg acaaatgatg gttatgtctt taatccagct gatattatcg   841260
aagatacggg taatgcttat atcgttcctc atggaggtca ctatcactac attcccaaaa   841320
gcgatttatc tgctagtgaa ttagcagcag ctaaagcaca tctggctgga aaaaatatgc   841380
aaccgagtca gttaagctat tcttcaacag ctagtgacaa taacacgcaa tctgtagcaa   841440
aaggatcaac tagcaagcca gcaaataaat ctgaaaatct ccagagtctt ttgaaggaac   841500
tctatgattc acctagcgcc caacgttaca gtgaatcaga tggcctggtc tttgaccctg   841560
ctaagattat cagtcgtaca ccaaatggag ttgcgattcc gcatggcgac cattaccact   841620
ttattcctta cagcaagctt tctgccttag aagaaaagat tgccagaatg gtgcctatca   841680
gtggaactgg ttctacagtt tctacaaatg caaaacctaa tgaagtagtg tctagtctag   841740
gcagtctttc aagcaatcct tcttctttaa cgacaagtaa ggagctctct tcagcatctg   841800
atggttatat ttttaatcca aaagatatcg ttgaagaaac ggctacagct tatattgtaa   841860
gacatggtga tcatttccat tacattccaa aatcaaatca aattgggcaa ccgactcttc   841920
caaacaatag tctagcaaca ccttctccat ctcttccaat caatccagga acttcacatg   841980
agaaacatga agaagatgga tacggatttg atgctaatcg tattatcgct gaagatgaat   842040
caggttttgt catgagtcac ggagaccaca atcattattt cttcaagaag gacttgacag   842100
aagagcaaat taaggctgcg caaaaacatt tagaggaagt taaaactagt cataatggat   842160
tagattcttt gtcatctcat gaacaggatt atccaagtaa tgccaaagaa atgaaagatt   842220
tagataaaaa aatcgaagaa aaaattgctg gcattatgaa acaatatggt gtcaaacgtg   842280
aaagtattgt cgtgaataaa gaaaaaaatg cgattattta tccgcatgga gatcaccatc   842340
atgcagatcc gattgatgaa cataaaccgg ttggaattgg tcattctcac agtaactatg   842400
aactgtttaa acccgaagaa ggagttgcta aaaaagaagg gaataaagtt tatactggag   842460
aagaattaac gaatgttgtt aatttgttaa aaaatagtac gtttaataat caaaacttta   842520
ctctagccaa tggtcaaaaa cgcgtttctt ttagttttcc gcctgaattg gagaaaaaat   842580
taggtatcaa tatgctagta aaattaataa caccagatgg aaaagtattg gagaaagtat   842640
ctggtaaagt atttggagaa ggagtaggga atattgcaaa ctttgaatta gatcaacctt   842700
atttaccagg acaaacattt aagtatacta tcgcttcaaa agattatcca gaagtaagtt   842760
atgatggtac atttacagtt ccaacctctt tagcttacaa aatggccagt caaacgattt   842820
tctatccttt ccatgcaggg gatacttatt taagagtgaa ccctcaattt gcagtgccta   842880
aaggaactga tgctttagtc agagtgtttg atgaatttca tggaaatgct tatttagaaa   842940
ataactataa agttggtgaa atcaaattac cgattccgaa attaaaccaa ggaacaacca   843000
gaacggccgg aaataaaatt cctgtaacct tcatggcaaa tgcttatttg gacaatcaat   843060
cgacttatat tgtggaagta cctatcttgg aaaaagaaaa tcaaactgat aaaccaagta   843120
ttctaccaca atttaaaagg aataaagcac aagaaaactt aaaacttgat gaaaaggtag   843180
aagaaccaaa gactagtgag aaggtagaaa aagaaaaact ttctgaaact gggaatagta   843240
ctagtaattc aacgttagaa gaagttccta cagtggatcc tgtacaagaa aaagtagcaa   843300
aatttgctga aagttatggg atgaagctag aaaatgtctt gtttaatatg gacggaacaa   843360
ttgaattata tttaccatcg ggagaagtca ttaaaaagaa tatggcagat tttacaggag   843420
aagcacctca aggaaatggt gaaaataaac catctgaaaa tggaaaagta tctactggaa   843480
cagttgagaa ccaaccaaca gaaaataaac cagcagattc tttaccagag gcaccaaacg   843540
aaaaacctgt aaaaccagaa aactcaacgg ataatggaat gttgaatcca gaagggaatg   843600
tggggagtga ccctatgtta gatccagcat tagaggaagc tccagcagta gatcctgtac   843660
aagaaaaatt agaaaaattt acagctagtt acggattagg cttagatagt gttatattca   843720
atatggatgg aacgattgaa ttaagattgc caagtggaga agtgataaaa aagaatttat   843780
ctgatctcat agcgtaagga atagcagtag aaaaagtctg aatcaaaaat gaagttctct   843840
caaaagttag aaataaaact ctgactttgg gagaatttca ttttattatt aatatataaa   843900
atttcttgac atacaactta aaaagaggtg gaatatttac tagttaatta attggttaat   843960
taatttattt aatcatttaa taatgaagac atcatataaa taattataga aatgaggtaa   844020
ttatgaaatt taaaaagaaa tatatagcag ctggatctgt tgttatcctt tccttaagtc   844080
tgtgtgttta tgctctgaac caacatagct aacaggccaa tacagataaa aatcgtgttt   844140
catatgtaaa cagtaataaa gacactaaga agactgaaaa tttgactcca gactaggtta   844200
gtcaaaaaga aggaattcaa gcaaaacaaa ttgttattaa gattacagat caaggttatg   844260
taacttctca tggcgatcat tatcactact ataatggtaa agttcctttt gatgcgctct   844320
ttagtgaaga gctattaatg aaagccccca actatcagcc gaaagatcaa gatatcgtca   844380
gttaggttaa gggaggatat attattaagg tagatggaaa gtattatgtt taccttaaag   844440
atcaagctca tgcagaaaat gtacgaacaa aagatgaaat caatcgccaa aaacaagaac   844500
atggtaaaga cgataaagga gctagtgcag aagtatctgt agcaaaatta cagggacgtt   844560
atactaccga tgatggttat atatagtgag ttgaatttag aatagcacat catagtttct   844620
aaatcattgt tagaaattac tttaaaatcc ccttatcaat ttgctcatat tctatttcaa   844680
tctactatag taccacatgg tggtcactat catttcattc ctgagagtga cttgtcggca   844740
ggtgaattag cagccacata tgtctttaac cctaatgata ttgtcagaga tacaggtgat   844800
gcttatatag taagacatgg ggatcactat cactatattc ctaagtcatc tcttaacaat   844860
cccccatcac actctaacac ggaagaggta ggaagttctt ctagttctgt attaagtaat   844920
ccgtcactac atgtccatca tgaggaagaa gatggtcatg gttttgatgc caatcgaatt   844980
ataagtgaag attcagaagg ttttgtgatt cctcatggcg accacaatca ctacatcaag   845040
gttcaaacta agggatatga agcggctttg aaaaacaaga ttccatccct gcaatccaac   845100
tatcaacctg gaacttttga tgagaaggca gtcttggcaa aagtagatca acttctagct   845160
gatagcagaa gcatctacaa agacagattg agttagcttt aggtcagttt actgaaagtt   845220
tgaaaaaaat aaaagttagt tgattgatta cttctctaaa ttttgggcac actaaaaaga   845280
ggtcttgaca cctaaacttt aaaattaaag catattgaat ccgtgctgct gtgcgaagcg   845340
aatagcgtct tggacgaaca ttgtcttatc tggatttctt atttctgtaa ggccttgtaa   845400
tcttggatta taactctcct gttttaggag tacatggtag atagcaacca ataatctgcg   845460
acagatagca aggaagaagt agaaagtctt ttgagcaagg caaatcaact cttggaacaa   845520
atccatgaag aaggaatcag acaatccttg gcagaagaag tagaaaatct aaaagctgcc   845580
acaaacaagg ctgatgcaga cttggatgaa gtaaacagtc aggtaaaaga tgtcttgact   845640
cgtatcgcta gcgcccttca acaagaaaag gaaaatgctg agcaagatcc tcagacactt   845700
gtactctatc aaaaactcta cgatattctc atgtcgcttc actcttattt agaaagtaat   845760
aatggatctg atgcggactt tgataaggtg gatgcattat tagatcaact ttctgctaag   845820
agtaaagaca aaacagcttt acttgaatcg acaaaagcta ttctagtttt gaatcatcaa   845880
atccagtcaa aagctagcgc aagtgaagaa acaagtccag caagaaatgc tgaagcaaat   845940
ggtgataaca ccagtgctga gaaccaacca aacgcaactg cagaatctaa cattgaaact   846000
gctagcgacg aaaacaaacc aagcaataca agagattcta aacctgctga atcaacttca   846060
gaaaatgaaa caacagaatc ttctacaact actggaaatc aagaaaaacc agtagaataa   846120
aaagaaaggc gaagtagctg agctacctcg tctttttagc ctttataagc tacgatgcca   846180
atgatggtat caactgcacg ttccatagtc tgaaggctaa cgtattcaaa acgtccgtgc   846240
atattttcgc cacctgcaaa gatattcgga gttgggattc ccataaagga aatcttagag   846300
ccgtctgttc caccccggat tggttcgata ataggcgtga tacctagatc ttccataacg   846360
gctttagcaa tggtaattgg agtcatatct ttttcaatga cttctttcat attgtagtac   846420
tggtctgtca agttgagagt gacacggtcg ctcccaagtt cttcattcat cttatcagcg   846480
atagattgca tggatgcttt acgcgcttca aaggcatctt tttcaaaatc acgaatgatg   846540
tagcttgcac gcgcctcctc aacactacct gtcacatcca ttagatggta aaaaccttgg   846600
taaccttcag ttaactcagg tcggtcattt tctggaagtt gattatgaaa atcaattgct   846660
agctgaaggg cattgaccat ctgccctttg gcagtaccag ggtggacatt acgaccttgg   846720
aaatgcaatt cagcaccagc ggctgagaaa gtctcgtact gaagttcacc tagtggacca   846780
ccatcaacag tgtaggcaaa atccacatca aaatcttctg catcaaattt attggcacca   846840
acaccgattt cttcatctgg accaaaacca acacgaatct cacagtgctt aatttcagga   846900
tgagcagtta gatattcaat ggctgtcata atttcagcaa ttcctgactt gtcatcagca   846960
cctagcaagg ttgttccatc tgttgtgatg agcgtttgtc ctggatattt ttcaagactc   847020
ttgaagtcag ctggatcgag tttgaaacca gaattcccta gttcaatcac accaccatcg   847080
tagttttcaa ttacctgtgg attgactcct tcagcattaa aatcagcagt atccatgtgc   847140
gatataaaac caatcttacg tgttaaagac ggatcgttgg ctggcaaggt tccaatagca   847200
aaaccattcg gtagatagta aacattttgc agtccaacac gtttcatttc aggaattagg   847260
acatttgttg cgaagtcaac ctgactctgt gtacttggag tagtagtaga gtgttcatca   847320
gagcgcgtgt tgaccttaac ataggttaag aagcggtcca agagatttgg ataagtcata   847380
aaaaaactcc ttttgaattt attttttcca ttgtatcata gaaagaagag aaaaacaaaa   847440
gacagaagat tgagaatgtc cctatgctag cgtttactta tcgatgaatt aatgataaaa   847500
taaacttgat aaaaacatca caaggaagca gtcatgaaaa aagcaatttt aatgatgacc   847560
ttcggttcac cagaagagat tatctttgaa ggtgtagctg attttttcac aaatattcgt   847620
cgtggggtga gaccccaaga ccacgagatt cagactcttt atgataatta tgtacgaatt   847680
ggaggcacgc ctctgcaaaa aattacccgt caagaggttg ccttggtaga agctaggctg   847740
gggagtgaat acagtgtcta ctttgctaat aagttttcca gtccctttat tccagatgtg   847800
atcggtcaaa tggaagcaga cggaattgaa cagtgtattt gcttgatttt ggagccccat   847860
tattctttct actctgtcat gggctatgaa aaatttttag aaagcaaaca aattcaattt   847920
ttggtcatta aggactggta tcaggaagaa gcgctcttaa actattgggc agatgaaatt   847980
gctaagattt taaaagaaga agtaaagcaa gacagcttta aagtcatctt ttcagcccat   848040
agtgtgccta tttttgcctt ggactttggt gatccttata tagaccaaat tttcgaaaat   848100
agcaagctag tcgctgaaaa actgggcttg agttcagaac aatataccaa cacttggcaa   848160
agtgagagtg atattggtat tccatggatt aaaccagatg ttttggagta tctcagagaa   848220
cagacagaac atccagacca ttatattttt gtacctatta gtttcatcag tgagcatatt   848280
gaggtcttgt ttgacaatga tgtggaatgt tatgacttat gtcaggaatt tggggtaaac   848340
taccatcgtc caccaatgcc aaatacagat tctcgtttga ttgatgcttt ggtcaataca   848400
gttagagtca atgaaaatca agagtttaag gaatttctcc cagaagaaga gacctttgat   848460
gagttagttc cttcagacga gacgaaaaac attttggctg aatctcaaga tttacaaatg   848520
ccagaatttg tgaaaaaatt gattgagaaa aaaggtcgtg aaaatgttaa gatgccttat   848580
cttatcaaaa aaatgcttga aaaagcaggc aagttaccca aagagtaaag aaaaaaggat   848640
ttagctttgc gctagatcct tttaatcgat tattttttct caaggagagc ttttatttct   848700
tgaaggactt ccaattcggt tggttttttt tcgtcagttt tttcttcctt tatgccagtc   848760
agcttctgtg ctttttcaat gcccttgata ataaagaaga gggcggtacc cacaaagata   848820
aaattgataa tagcacttaa gaagttacca tagccgactc catgccaaga aagttgagcg   848880
atacgttcaa ctttagcagc tttcaaagcg ggatttaaaa taagaggagt gataatgtcg   848940
tttacaagtg aagtaacgat agcaccaaaa gcagaggcaa ttacaacacc gacagcaagg   849000
tcaataacat ttcctcgaag caagaacgat tttagatttt ttaacatact gttttccttt   849060
caatgtttcg tgtttcattg tatcctaaat cattatagaa ggcaattaaa aggctcataa   849120
atggagcatt attttctaaa aatatagacc ttgctcaaga tataattgat gataataatg   849180
aatatttgtg caattattgt ttcaatagca tttatcttat caatgttttc agttacgaat   849240
tgccctatga tgtgaggaaa ttgggttaca aagagaaaag ttaaaaacaa gtctaacaga   849300
aaagtagaaa ggcgggcaag agaaaatttc actaaacgga taagtctatt tttctttttt   849360
tgcttaaata caatcgtatc atttgtgata aaggcaaata ggataccgat aatatttgcc   849420
aaggccgtag caaggagttc ctgatgactt agctgataaa tgactaatcg tgatagtata   849480
gcaacaagag tagtcactat accaaaaaag agataggcta agatttcatt gttaaaaaat   849540
ttttgaatag gttttttcat gctttaagta tagcataaag caggctattg tgctatacta   849600
gtaaggttga atgaatcaac ccttggtgct tagcttcttt caccaagcat attacacgcg   849660
gataaccgcc aaaggagaaa agatgaaaaa attaactatt cgtgatgttg cagatattgc   849720
aatcgtcgct gctatctacg tcgttttgac tgtcacaccg cccctaaatg ccatcagcta   849780
tggtgcttat cagtttcgta tttcagaaat gatgaacttt atggcttttt acaatcctaa   849840
gtacatcatc ggagttacca tcggttgtat gattgctaat ttctttagct tcggactgct   849900
agatgtcttt gttggtggtg gttcaacctt agtattcctc agtttaggtg tttggctttt   849960
tgcaaaatat agcaaggatt acctctttaa cggattgatt cgaaaagatc atttcttctt   850020
ttcaatcctc ttttcaattt ccatgtttac tatcgctgca gagttaaata ttgtagcaga   850080
attaccattc ttccttactt ggtttacaac aggaatcggt gaatttgctt cattgattat   850140
tggagcgatt attattggta aaattggtcg tcgaattgat ttaagtaaat agaagaagat   850200
aagctaggta gtttttacct ggctttttcc tatggaaaat ttctaaggaa acttgacaag   850260
tttttctgaa tatagtatac ttcttaagta agctgattta gctcagttgg cagagcgcat   850320
ccatggtaag gatgaggtcg ccggttcaat cccggcaatt agcatgatat gtatagggaa   850380
actcttgaat acgagagttt tttgttatac tcgatctgaa aaatttctta ttgacaaaat   850440
caagtatctc tagtaatata gaatatgcga tgagtcgata ggtagtcttc ggactactat   850500
tgagcatgag gaggtcataa cgcaggagcg gaccttgatg agttgtgtga acctgctcat   850560
cacatgaaga tgcctcttag tccctagtct agcgactggg atttttattt tccaaaaaat   850620
gatgaaaaag ctttgcaatt catggaaaaa gtagtataat acttctatta tagaaatttt   850680
tagaaaattc cgaaagaggt tatttatggg atatacagtt gctgtagtcg gcgcgacagg   850740
tgctgtcggt gctcagatga taaaaatgtt ggaagaatca acacttccaa tcgataaaat   850800
tcgttacctt gcttctgcac gttcagcagg taagtcattg aaatttaaag atcaagatat   850860
tacaattgaa gaaacgactg aaacagcttt tgaaggagtt gatattgctc tcttttcagc   850920
aggtagttct acatcagcta agtatgcacc atacgcagta aaagctggcg tggtagtagt   850980
agataataca tcttatttcc gtcaaaatcc agatgttcct ttggttgttc cagaggtcaa   851040
tgctcatgca cttgatgctc acaacggaat cattgcctgc cctaattgtt caacaattca   851100
aatgatggtg gctcttgagc cggttcgcca aaaatggggc ttggaccgta tcattgtttc   851160
aacttatcaa gccgtttcag gtgctggtat gggagcaatt cttgagacac aacgtgaact   851220
tcgtgaagtc ttgaatgatg gtgtgaaacc acgtgatttg catgcggaaa tcttgccttc   851280
aggtggtgac aagaaacatt atcctatcgc ctttaacgct cttccacaaa ttgatgtttt   851340
cactgataat gattacacgt acgaagagat gaagatgacc aaggaaacta agaaaattat   851400
ggaagatgat agcattgcag tatctgcaac atgtgtgcgt attccagtct tgtcagctca   851460
ctctgagtct gtttatatcg aaacaaaaga agtggctcca atcgaagaag taaaagcagc   851520
tatcgcagcc ttcccaggtg ctgttcttga agatgatgta gctcatcaaa tctatcctca   851580
agctatcaat gcagttggtt cgcgtgatac ctttgttggt cgtatccgta aagacttgga   851640
tgcagaaaaa ggaattcaca tgtgggttgt ttcagataac cttctcaaag gtgctgcttg   851700
gaactcagtt cagattgctg aaactcttca tgaacgtgga ttggttcgtc caacagccga   851760
attgaaattt gaattaaaat agtcatatcg tttaggagtt cagatgaact ccttctttga   851820
aatagagagg tgttttcgtg tcttatcaag atttaaaaaa atgtaaaatc attacagcct   851880
ttattacccc cttccatgag gatggttcca ttaactttga tgctattcca gccttgattg   851940
agcatttatt ggcccatcat acggatggaa ttcttctcgc aggaacgact gctgagagtc   852000
caactttgac ccacgatgag gagttggagt tgtttgcggc tgtacaaaag gttgtcaatg   852060
gacgcgttcc tttgattgcg ggtgtaggta ctaatgatac gcgtgactct attgagtttg   852120
tcaaagaagt agcggaattt ggtggtttcg cagctgggct tgctattgtt ccttactaca   852180
acaaaccttc tcaagaaggg atgtatcagc actttaagac tattgcagat gcttctgacc   852240
taccaattat tatctataac attccagggc gtgtagttgt cgaattgact ccagaaacca   852300
tgcttcgctt ggctgaccat ccaaatatta tcggtgtcaa agaatgtact agcttggcta   852360
atatggctta cttgattgag cacaagcctg aagagttctt gatttataca ggtgaggatg   852420
gagatgcttt ccatgccatg aaccttgggg cggatggggt tatttctgtt gcctctcata   852480
caaatgggga tgaaatgcac gagatgttta ctgcgattgc agaaagcgat atgaagaaag   852540
ccgcagcaat tcagcgtaaa ttcattccta aggttaatgc tctcttctct tatccaagtc   852600
ctgctccagt taaggcaatt cttaactata tgggatttga agctggaccc actcgtctac   852660
ctcttgttcc agcaccagaa gaagatgcca aacgcattat caaggttgtc gtagatggcg   852720
actacgaagc aactaaggca actgtaacag gggtcttaag accagattac taataaagac   852780
aataaaatcc ggctctttgt caactgtagt gggttgaagt cagctaagct cgagaaagga   852840
caaattttgt cctttctttt ttgatattca gagcgataaa aatccgtttt ttgaagtttt   852900
caaagttccg aaaaccaaag gcattgcgct tgataagttt gatgagatta ttggtcgctt   852960
ccaatttggc gtttgaatag ggtagttgaa gggtgttgac gattttcttt ttgtccttta   853020
gaaaggtttt aaagacagtc tgaaaaatag gatgaacctg cttcagattg tcctcaatga   853080
gtccgaaaaa tttctccggt tccttattct gaaagtgaaa cagcaagagt tgatagagct   853140
gatagtgatg tttcaagttt tgtgaatagc tcaaaagctt gtttaaaatc tctttattgg   853200
ttaagtgcat acgaaaagta ggacgataaa atcgcttatc actcagttta cggctatcct   853260
gttgaatgag tttccagtag cgcttgatag ccttgtattc atgggatttt cgatgaaact   853320
gattcatgat ttggacacgc acacgactca tagcacggct aagatgttgt acaatgtgaa   853380
agcgatccaa cacgatttta gcacacggga aaagttgtct agctaagtca tagtaaggac   853440
taaacatatc catagtaatg attttgacgc gacatcggac ggctctatca tatttaagaa   853500
agtgatttcg gatgacagct tgtgttcttc ccttaagaac agtgatgata ttgagattgt   853560
taaaatcttg cgcaatgaag ctcatctttc cttttgtaaa agcatactca tcccaagaca   853620
taatctcagg aagacaagaa aaatcatgtt taaagtgaaa gtcattgagc ttacgaataa   853680
cagttgaagt tgagatggaa agctgatggg caatatcagt catagaaatc ttttcaatta   853740
acttttgagc aatcttttgg ttgatgatac gagggatttg gtgattcttc ttgacgatag   853800
aagtttcagc gaccatcatt tttgaacagt gatagcactt gaatcgacgc tttctaagga   853860
gaattctagt gggcatacca gtcgtttcaa gataaggaat tttagaaggt tttttgaaag   853920
tcatatttct tcaattggtt tccgcactca gggcaagatg gggcgtcgta gtccagtttg   853980
gcgatgattt ccttgtgtgt atccttattg atgatgtcta aaatctggat attagggtct   854040
ttaatgtcta gtaattttgt gataaaatgt aattgttcca tatgattctt tctaatgagt   854100
tgttttgtcg cttttcatta taggtcatat gggacttttt ttctacaata aaataggctc   854160
cataatatct atagtggatt tacccactac aaatattata gaacctaaaa tccatgaccg   854220
aatgaaggat catggatttt tcttattttc ctaaacagaa ttggctaaag agttgggtga   854280
tgagttcatc tggagcagca tctccagtga tttctcctag aatttcccaa gtacgggtca   854340
agtcaacttg aagcaagtca actggcatcc ctagttcaag accttggtta acagcttgta   854400
ggctttcaac ggccttctca atcaaggaaa tgtgacgggc gtttgacaag taggtagcat   854460
cttgctcaac caaaccagca ttttcaaaga agaggttgtt gattctctct tcgattttat   854520
cgatgttttg atttttaaga actgaaatgc ggatgacatc ttcaggtagt tccgaagttt   854580
caatcgtttc aggcaggtca gttttgttaa gaagaataat gcgattagtc tcctgactga   854640
tttctaggag ttggcgatct tgggcggtta gtggttcact agcgtttagt actagcagaa   854700
ctaggtcagc ttccttaaga gcttttttcg aacgctcaac tccaatttgt tcaacgatat   854760
catccgtttc acgaataccg gctgtatcaa tcaatttgag aggtacacca ttgatgttga   854820
cgtactcttc gatgacatct cgtgttgtcc cagcgatatc tgttacgata gccttgtcct   854880
cacgcaagag gttgttgaga aggcttgatt tcccaacgtt gggacgtcca atgatagccg   854940
ttgaaattcc ttcacgaagg attttaccac gacgtgctgt cctaaggagt ttggttagta   855000
attgctcaaa ctccattgtc ttctctcgga caacagcagt agtggcttcc tcaacatcgt   855060
catactcagg atagtcgata ttgacctcaa cttgggcaag tgtattgagg atttcttgac   855120
gggtattgtt aatgaggtca gaaagggagc cgtctaattg tttgaccgca atgttcatgg   855180
ccttgtcagt cttggcacgg atgatatcca tcacagcctc tgcctgtgtc aagtctacgc   855240
gaccgtttaa aaaagcacgt ttggtaaatt caccaggttc tgccaaccga gccccttcac   855300
gaatagctag ctggagaatt tcattggtca ccgcaatccc accgtgggtg ttaatctcga   855360
taatatcctc acgagtgaag gtctttggag acttcatagc cccaaccata acctcgtcca   855420
tgactttacc agtcagagga tcaataatgt gaccgtagtt gagagtgtgg ctggcaacct   855480
tgttcaagtc ttttccttta aaaatctttt gcgcaatagc aaaactgtct gttccgctca   855540
ggcggacaat accaatagcc ccttcaccta gtggagtaga gatagcagcg atggtatcaa   855600
attcacgtgt aatcataatg tttcctttaa ttaatagctc ttttcttgga aattctccaa   855660
gtttcttttc aaattgtaac aaatttagga tatttcttca atgaatgcta cttggagatt   855720
gaaaaagcct aagcaattct gcttaagcta gcttatttag tacgcatttc cccttgtggg   855780
aagtaagttc cttctggcat gtcgttgatg atgacatgga cagcagattg aggggctcca   855840
gtgttgcgga caactgcttc cgttacttcc ttagcaagag ctttcttttg ctcgagcgtg   855900
cgtccttcaa ataaatcgat gcgtacaaat ggcataatag cttcctccac tagtttttga   855960
tttcttctat tttaccacat tttgccgttt aaagcttaag aaaattatga tatactagaa   856020
tgtagcaaaa atttagaaat ggacgtgaag caagaaacat ggcacagttg tactatcgtt   856080
atgggaccat gaactctggt aaaacgattg agattctcaa agtggcctat aactacgagg   856140
agcaaggaaa aggtgttgtg attatgacct cggctctgga tacgcgtgac ggcgttggct   856200
atgtgtcgag tcgaattggc atgaaacgcc ctgcccttgc gattgaggaa acaacggata   856260
tctttggcta tatccgagac ctaccagaaa aaccttactg tgttttggtc gatgaagccc   856320
agtttctcaa acgccaccat gtttacgacc tagctcgtgt tgtggacgag ttagacatac   856380
ccgtcatggc ttttggcttg aaaaatgact ttcgcaatga attgttcgaa ggttccaaat   856440
atctcttgct tttagcagac aagattgacg aaatcaagac catctgtcag tattgcaaga   856500
aaaaggcgac catggtgttg cgaacacagg atggactgcc cgtttacgat ggagaacaga   856560
tccagattgg tggtaacgaa acctatatct cagtttgccg taaacattat tttgcgccaa   856620
tgataacctc taacaaggag caaaactatg acaattgaac taagagatgt tacaatggaa   856680
aattattttg atgttttaaa tttggatgtc aaggaatatc aaaaacaatt cattgcaacc   856740
aacgcaatta gtttagctga agcatacgtc tacactaaaa atggagattt tgtagctcca   856800
ttggcagttt atgataatga tgcaattata ggttttgtga tgatagctta tgataaaaag   856860
atcggaatta gtagtggaaa ttatttacta tttcgtttta tgattgataa gaattttcaa   856920
aatcaaggat attttaaacc aattatggat aaagtactag actatgttcg aacagcgcca   856980
gcaggtttaa gcaataaact ttggttgtct tatgaaccag aaaatgaaca ggcaagattt   857040
tgttacctca gttatggatt taaagaaact ggggaaatat ccgagaatga agtagtagca   857100
atctatgatt taacaattga gaaataagga gaaaaaatga acatctatga tcaactacaa   857160
gttgtagaag accgttatga agaattagga gaattgctga gtgaccctga tgtcgtttca   857220
gacaccaagc gttttatgga gctttcaaaa gaagaagctt ccaatcgtga caccgtaata   857280
gcctaccgtg agtataaaca agtccttcaa aatatcgtcg atgccgaaga gatgattaag   857340
gaatcaggcg gagatgcgga cttggaagaa ttggccaagc aagaactcaa agatgccaag   857400
gctgaaaaag aagaatatga agaaaaactg aaaattttgc tccttccaaa ggatccaaac   857460
gatgacaaga atatcatcct tgaaatccgt ggagcagctg gtggagacga agcggcactt   857520
ttcgctggag atttgctaac tatgtaccaa aagtatgcgg aagcccaagg ttggcgcttt   857580
gaagtcatgg aagcctctat gaatggtgtc ggtggtttta aagaagtggt tgctatggtt   857640
tcaggtcagt ctgtatactc taagcttaag tatgaatcag gtgcccaccg tgtgcaacgt   857700
gttcctgtga cagaaagcca aggccgtgtt catacttcga cagcgacagt tcttgttatg   857760
ccagaagttg aagaggttga atacgacatt gatccaaaag accttcgtgt cgacatctat   857820
cacgcctctg gtgctggtgg acagaacgtc aataaggttg cgactgccgt tcgtatcgtt   857880
cacttgccaa ccaatatcaa ggttgagatg caggaagaac gtacccagca gaagaaccgt   857940
gagaaggcca tgaaaatcat ccgtgcccgt gttgctgacc actttgctca gattgctcaa   858000
gatgagcagg acgctgagcg taagtcgaca atcggtactg gtgaccgttc agaacggatc   858060
cgaacttata acttcccaca aaaccgtgtc acagaccacc gtatcggctt gaccctccaa   858120
aaactagata cgattttgtc tggtaaattg gacgaagttg tggatgcctt ggtgctttat   858180
gaccaaacac aaaaactaga agaattaaac aaataatgaa attagctcaa ttattttcaa   858240
attttgaaga agagttgata agacaaggag aggaagcgga aagcctctct tttgtctatc   858300
gtagtctgaa aaatctatct tttacagact ttatttttgc cctccagcag gaggtgacaa   858360
cagaggaaga aaaacaattt gtagaagata tttaccagca actagcagct cacaagccag   858420
ctcagtacat cattggacag gcagattttt atggaatgca tttaaaggtg gatgaacggg   858480
ttttgattcc tcgtccagaa acagaggagt tggtggagct tatcctggct gaaaatcctg   858540
tgaaaaatct tatggtccta gatatcggaa caggtagtgg agctattgct ctcgctctag   858600
caaaaaacag accagattgg tcagtgacgg cagcagatat ttcccaagat gctttagatg   858660
tagctagcga aaatgctaaa aatcaaaatc ttcaaatatt tttaaaaaaa tctgactgtt   858720
ttacagaaat ttctgaaaaa tatgatataa ttgtttccaa tccaccctat atctctcgtg   858780
aagatgagtc agaggtaggc ttgaatgtct tgtattcgga gcctcatcta gctctctttg   858840
cagatgagga tggcctagct atttaccgta gaattgcgga agatgcaaaa gactatctca   858900
aagatggtgg taagatttac cttgaaattg gatacaagca aggtcaaagt gttcctgaac   858960
tttttaggaa acatcttcct gaaaagcgag tacgaacact caaggaccaa tttggtcaag   859020
ataggatggt tgtcgttgat gatggacagg attagacaag agttggaaaa tggtggagct   859080
gtcgttttgc ctacagagac agtttacggt ctctttgcta aggcgctaga cgaaaaagca   859140
gttgaccatg tttaccagct taaacgtcga cgtagagaca aggcgctcaa tctcaatgtt   859200
gcctctttag aggacatctt gtacttttca aagaatcagc caacttatct tcaaaaactt   859260
gtagagatct ttttaccagg tcccttgacc attattctcg aagctaatga ccgagttccc   859320
tattgggtca attctggcct tgcaactgtt ggatttcgga tgcctagtca tcccattacc   859380
cttgatttga ttcgagagac aggtcccttg attgggccgt ctgccaatat ctcaggtcag   859440
gcgagtggag tgacctttaa tcaaattcta gaggattttg accaagaggt tctgggtctg   859500
gaagacgatg cttttctaac tggacaggat tcaactattt tgaatttgtc gggagacaag   859560
gtgaaaatct tacgtcaagg ggccattaag cgagaagata ttcttgctcg gttgccaaag   859620
atttcttttg aggaggaatg agatgctaag agatttaaga gaaactgatg tgaaagctat   859680
atgtgacatc aaccaagagg ctttgggtta tacttttagt ccagaggaaa cggctagcca   859740
actagctaga ctgtctcagg attcccatca tttcctactt ggctatgagg atgcagctaa   859800
tcatgtctta cttggatatg tccacgctga agtttacgaa tcactctatt ccaaagcagg   859860
atttaatatc ttagctttag cagtttcacc tcaagcgcaa ggtcaaggta ttggtaaaag   859920
tttactacaa gggttggaag aagaagcaaa aagatgtggt tatgggttta tccgcttaaa   859980
ttctgccaat catcgtctgg gtgctcatgc attttatgaa aaagttggct atacttgtga   860040
taaaatgcag aaacggttta ttcgcatctg ttagtttgat tttcttattg taaaatcaaa   860100
ctaatggact agtcacacaa taaaggagaa gacctatgat ttttgacaaa gatgatttta   860160
aagcatatga tgctgatctc tggaatgcta ttgccaaaga agaagaacgc caacaaaata   860220
atatcgagtt aattgcttcg gaaaacgtag tttccaaggc tgttatggca gctcaagggt   860280
ctatcttgac aaataaatat gccgagggtt acccaggacg ccgttattat ggtggaactg   860340
atgtagtaga cgttgtagag actcttgcta ttgaacgcgc aaaagaaatt ttcggtgcta   860400
aatttgccaa tgttcaacca cattcaggaa gccaagctaa ctgtgcggct tacatgtcct   860460
tgattgagcc aggtgatacg gttatgggaa tggatttggc atcaggtggt catttgactc   860520
atggggctcc tgttagcttc tctggtcaaa cctacaactt tgtttcttat agtgttgatc   860580
ctaaaacgga actcttagac tttgatgcta tcttgaaaca agcccaagaa gtaaaaccaa   860640
aactgattgt agctggtgct tcagcctatt ctcaaattat cgatttttca aaattccgtg   860700
aaatcgcaga tgctgtcggt gcgaagctca tggtggacat ggcccatatc gctggcttgg   860760
ttgcggctgg ccttcatcca agcccagttc catacgctca tatcacaaca acaacgaccc   860820
acaaaaccct tcgtggacct cgtggtggtt tgattttgac caatgacgaa gaacttgcta   860880
aaaaaatcaa ttcagctatt ttcccaggta ttcagggcgg tcctttagag catgttgtgg   860940
cggctaaggc agtttccttc aaagaagttt tggatccagc cttcaaggaa tatgctgcca   861000
atgtaattaa gaacagcaag gctatggcag atgtcttctt gcaagaccct gatttccgta   861060
ttatttcagg tggaactgaa aaccatctct tccttgttga tgtgactaaa gttgtagaaa   861120
acggcaaagt tgctcaaaac ttgttggatg aagtcaatat taccttaaat aaaaactcaa   861180
tcccttacga aagcttgtca ccattcaaga caagtgggat tcgtatcgga gcagcagcca   861240
ttactgcacg tggatttggt gaagaagaaa gtcgcaaagt ggctgaactc atcattaaaa   861300
cccttaagaa ttcagaaaat gaggctgtat tagaagaagt gagaagtgca gtcaaagaat   861360
tgacagatgc cttcccatta tacgaggact aaaactttta tggacattta tattaagaaa   861420
gccattattc accagttcag tccggatgat accgaactgt tcttagcaga taagtttctc   861480
aatattactc caaaaatcga agaatacctg cgtaaaaaaa ttgaacatgt gtattcagat   861540
gaagccaaga ctgggatttt cgaagaagaa aatcccttct tcaatcatat tacagacgat   861600
ttgttggaga catcagtaac gctggctaat ctctggaaag aggagtttag catttctgaa   861660
aatctcaaga ccaatgactt gatttttgtg caattttcta aagaaggtgt agaacatttc   861720
gctttcttgc gaattgccct gcgggagacc ttgacccacc tcggaggaga agttgataat   861780
ccaatcaagc taactcagaa taacctgcct ggatttggaa caggagctga tgaggccttg   861840
gtggtcaatc ttcagagtag caagtatcac ctgattgaaa aacgaatcaa gtacaacggg   861900
acttttttga actatttttc agataatctt cttgctgtcg ctcctaagat ttctcctaaa   861960
aaatctatca aggaactgga aaaaacagcc cagagaattg ctaaatcttt taacacagat   862020
gattttcaat ttcaatccaa ggtcaaatca gctattttca acaacctaga agaaagcaat   862080
gaattgtcac ctgagaaatt ggctaatgac ctttttgaca acaatctgac ggctcgtttg   862140
agctttattg accaagtcaa agaagccgta ccagaacctg ttcaatttga tgaaattgat   862200
gccagtcgcc aattaaagaa atttgaaaac caaaaactct ccttatcaaa tggaattgag   862260
ctcatcgttc ccaataacgt ctatcaagac gccgagtctg ttgagtttat ccaaaacgaa   862320
aatggaacct actctatctt aatcaaaaat atcgaggata tccaaagtaa ataatgttta   862380
aacgaattcg aagagtgctt gtactagcag tcttcctttt tgctggctat aaagcttacc   862440
gcgttcatca agatgtcaaa caagtcatga cctatcaacc catggtgcga gaaatattga   862500
gtgaacaaga caccccagca aacgaagagc ttgtgcttgc tatgatttat actgaaacaa   862560
aaggaaaaga aggcgatgtt atgcagtcta gtgagtctgc aagtggttcc accaacacca   862620
tcaatgataa tgcctctagc attcggcaag gcattcaaac tctgacaggc aatctctatc   862680
tggcgcagaa gaagggggta gatatctgga cagctgttca agcctataat tttggacctg   862740
cctatatcga ttttatcgcc caaaatggca aggaaaatac cctggctcta gccaaacagt   862800
actctcgtga gactgttgcc cccttgcttg gtaataggac tggaaagact tatagttata   862860
ttcaccccat ttccattttt cacggtgctg aactctatgt aaatggagga aactattatt   862920
attctagaca ggtacgactt aacctttaca tcatcaaatg tttcactctc ttttcaacat   862980
ctggctagac caggtgtttt tgttataagt tttctttaag atagatatat tactctaaag   863040
aagtaaagga ggaaattccc tatgagaaag aaactctttc tgactagcgc tgcgatcttg   863100
tgggcagtaa cagctatgaa tagcgtccat gcagcaacag atgttcaaaa agttatcgat   863160
gaaacctatg tccaacctga atatgtccta ggttcctccc tatctgaaga ccaaaaaaat   863220
caaactctta aaaaactggg ctacaatgcc tcaacagata ccaaagaact caagaccatg   863280
acacctgatg tttattctaa aatcatgaat gtggccaatg actctagctt acagttgtat   863340
tcatcagcca agattcaaaa gctaggtgac aaatcgccac ttgaggtcaa gattgaaaca   863400
ccagaaaata tcactaaggt gactcaggat atgtaccgaa acgcagcagt aacgctgggt   863460
atggaacatg ccaaaatcac tgtagcagcc cctattccag ttacaggaga aagtgcttta   863520
gcagggattt actattcgct agaggctaat ggagccaagg tgccacaagc taataaagat   863580
ttggctcaag aagagctaaa agctttgtca gatatcaatg ctgaaaacaa ggacaaatca   863640
ggctatgatg ctaataaatt aaacgttgcc ctagctgata tcaagtcagg actcgccaaa   863700
gctaaagaaa gtaagggaaa tctgacagaa gaagatatcc gcaagattgt tgaagatacc   863760
ttaaaaaatt acaaacttga tcaggtcata acaggaaacc agatcaatat catcatcaat   863820
tttgccttga atctctcaaa gagtgatatc ctcagcaatg cagatttcac taaaacccta   863880
aatgacctta aacaaagcat cgtatcacaa gctggcgaca gttttaaaaa tatcaacctt   863940
aactttgatg cggataaggc gctagaggac ggtggtaact tcttaagctc cctctggcaa   864000
gcccttgtca acttcttcaa gagttttggt tcttaagaaa tttcatggta taatggatgg   864060
taaccgtaac gttgccgtct tttttgtcgg ccaatagaaa gagaaaagaa tgttaaagaa   864120
aaatgatatt gtagaagttg aaattgttga tttgacccat gaaggggcag gagttgccaa   864180
ggtagatggt ttggtctttt ttgtagagaa tgctttaccg agtgaaaaaa ttctcatgcg   864240
tgtcctcaag gtcaataaaa agattggctt tggaaaagtt gaaaaatacc ttgtccagtc   864300
accacaccgt aatcaagatc tagatttggc ttacctgcgt tcaggaatcg cggatttagg   864360
acacctttct tatccagaac agctcaagtt taaaaccaag caagtcaagg acagtctcta   864420
caagattgct ggaattgcag atgtagaagt tgctgaaacg cttggtatgg aacatccagt   864480
caagtatcgc aataaggcgc aggtgcccgt tcgtcgagtg aatggtgtct tggaaacagg   864540
atttttccgt aagaattcgc ataacctcat gccccttgaa gatttcttta tccaggatcc   864600
tgtcattgac caagtcgtag tagctcttcg agacctgctc cgtcgttttg atttaaaacc   864660
ttatgacgaa aaggaacagt ctggattgat tcggaatctt gtggtgcgtc gtggtcacta   864720
ttcaggacaa atcatggtcg ttttggtgac aactcgtcca aaagtttttc gtgttgacca   864780
attgattgaa caagttatca agcagttccc agagattgtg tctgtcatgc aaaatatcaa   864840
cgaccagaat accaatgcga tttttggtaa ggagtggcgc actctttatg gtcaagacta   864900
tattacggac cagatgttgg gaaatgactt ccaaatcgct ggcccagcct tttaccaagt   864960
caatactgaa atggcggaga aactctatca aacagccatt gactttgcag agttaaaaaa   865020
agatgatgtg attattgatg cctattctgg tattggaacc attggtttat cagtcgccaa   865080
gcatgtcaaa gaagtctacg gtgttgaact gattccagaa gcagtagaga atagccagaa   865140
gaatgcttct ttgaacaaga ttactaatgc ccactatgtc tgtgacacgg ctgaaaatgc   865200
catgaagaaa tggctcaagg aaggtattca accaaccgtt atcttggttg atcctccacg   865260
caagggcttg acagaaagct ttatcaaagc aagcgcccaa acaggagccg atcgcatcgc   865320
ctatatctcc tgcaatgtcg caaccatggc gcgtgatatt aaactatacc aagagttggg   865380
atatgaattg aagaaagtcc agccggtgga tctatttcct caaacgcatc acgtcgagac   865440
ggtagcactt ttgtccaaac tcgatgtcga taagcacata agtgttgaaa ttgagctgga   865500
tgagatggat ttgacaagtg cggagagcaa agcaacatat gctcaaatca aagaatatgt   865560
ttggaataaa tttgaattaa aagtttcgac attatatatt gcacagataa aaaagaaatg   865620
tggaatagaa ttacgagaac attacaacaa gtctaaaaag gataaacaaa ttattccaca   865680
gtgtacacct gaaaaagaag aagccatcat ggatgctttg agacacttca aaatgattta   865740
atagaaaaga atgacagtat atgactttct gcatttatta cattcctact tggtatagga   865800
acagctatta ttcctttctt gcaaggtatc aattagaaaa taggctcaat ataaagattg   865860
ataggatcat ttttatattt aaaggagcgt tgaaatgatt gataaaggca acaaaaaatt   865920
ttaggataaa tttgctaagt tgtatgcctc ttttatgaaa aaagataaag aggtttatga   865980
taaagtttgt gaatatctta gtcctcattt gaataaagat atggaggtgc ttgaacttgc   866040
ttgttggttt cgtgtcataa cagttataga ggcaaatagt tatgtaaata taaggagttc   866100
aagacttcta ccaaagttta aaactcaaaa aataaatagt tggtgtgctg cttacaatat   866160
ccattttaat aatggatatt gtaagcagca cacctaatga atttaaagat tctttaaaga   866220
gtcttatttt gtgatgaaaa tttaatatgt aaatctcaga cgatagaaat taaaaactct   866280
atcgtctttt ttatactcaa aattaggagg taaaaatggt aaggataaga ggtcccactt   866340
aaaacaattt atggcaaaat aaggacggaa taacacaaca aattctctaa aacaaatcac   866400
taaatcaatg taagattgaa tgaaatcaat atttatgcta taattaaata aatttaatga   866460
agaaaaaaag agggatatta tggcacttaa ctataaacca ttatggatac agttagcaaa   866520
aaaaggacta aagaaaacag atgtaatagc tatggcagga cttacaacaa atgttatggc   866580
acaaatggga aaggataaac caattacatt taagaattta gaaagaatat gtaaggcttt   866640
atcttgcact cctaatgata ttattagttt tgaagataat tttagtgacg aggaatagaa   866700
aatgacttta aggacagaag atcaagttag ggattatgca agagaagtat aggctttaat   866760
gaagttgaag aaaacatcaa tcaaggtact ggtcaaataa ctacttttaa tcaattaggc   866820
ttcaagggat attcaaataa gccagatggt tggtatttac ctaaaaatat gaatgatgta   866880
gcaataatcc ttgaaacaaa atcagaagaa agagatatta gcaaacaaat ttttattgat   866940
gagttaatga aaaatataga cataatttaa ctaaaaataa aaactagatc cttttttgaa   867000
aaaattatat tattaaattt gtaactgtat ctattgacaa tgataattat tatcgataca   867060
atagacttga aatatgttta aggagttttt atgaaaaaca aattttttct aatagctatt   867120
ttagctatgt gtatagtttt tagcgcttgt tcttctaatt ctgttaaaaa tgaagaaaat   867180
acttctaaag agcatgcgcc tgataaaata gttttagatc atgctttcgg tcaaactata   867240
ttagataaaa aacctgaaag agttgcaact attgcttggg gaaatcatga tgtagcatta   867300
gctttaggaa tagttcctgt tggattttca aaagcaaatt acggtgtaag tgctgataaa   867360
ggagttttac catggacaga agaaaaaatc aaagaactaa atggtaaagc taacctattt   867420
gacgatttgg atggacttaa ctttgaagca atatcaaatt ctaaaccaga tgttatctta   867480
gcaggttatt ctggtataac taaagaagat tatgacactc tatcaaaaat tgctcctgta   867540
gcagcataca aatctaaacc ttggcaaact ttatggagag atatgattaa aattgattca   867600
aaagccttag gtatggaaaa agaaggtgat gagttaatca aaaatactga agctcgtata   867660
tccaaagaat tagaaaaaca tccagaaatc aaaggaaaaa tcaaaggaaa aaaagtatta   867720
tttactatga ttaatgctgc agatacatca aaattctgga tttatactag caaagatcca   867780
agagcaaatt atttaacaga tttaggtcta gttttccctg aatcattaaa agaatttgag   867840
agtgaagata gttttgcaaa ggaaatttct gcagaagaag caaataagat aaatgatgct   867900
gatgtaatca taacttatgg tgatgataaa actcttgaag ctttacaaaa agatcctctt   867960
ttaggtaaaa taaatgcaat taaaaatggt gccgttgctg taattccaga taatacaccg   868020
ttagcagcct catgcactcc aacaccactt tcaataaact atactattga agaataccta   868080
aatcttttag gaaatgcatg caaaaatgcg aaataaaaaa caaataaacc taggcataat   868140
ttttataatc tgcctaggtc ttcttattac aatatttttg tcattaaagc ttggaacaaa   868200
agaaattaat atcagagatt ttttagcagc ttttggaatg ggtaatacaa atgatgattt   868260
tattaaatca attatatata aaagaatacc tagaactatt tttgcaattt tagcaggttc   868320
tagtcttgcc ataagcggtg tattgatgca atcagttact agaaacccaa tagctgatcc   868380
aggtatactc ggtataaaca caggagcaag tcttagtgta gtaattggtc tttctttttt   868440
aggaatttca tcaagcataa gccatataag ttttgcaatc attggtggct tagtaagtgc   868500
aatttttgta tacgcgattg ctgtaagcgg aaaagcaggc cttaccccta taaaacttgc   868560
cttatcagga acttgtgtta gtatggcttt aagcagtttt gtaagttttt taattttacc   868620
gaataataac gtcttagaca aatttagatt ttggcaaata ggtagccttg gagcagctac   868680
attatcttct atatctacac tactaccttt tataatttta ggtcacttga tagctatatt   868740
tatttcatca gatttaaacg ctttagctat gggtgatgaa atggctgttg gtcttggagt   868800
taatgttaat aggataagat cacttgcaat aattgcaagt gtgcttttat gttcaagtat   868860
tactgcaatt ggtggaccta ttggcttcgt aggtcttata gttcctcact tttgtggctt   868920
atttataagc aaagatatac gcacaatgac catttcttca tcttttatag gtgcagagct   868980
cttgcttata tgtgatataa tcggccgtat gttaggtaaa ccaggtgaaa ttgaagtagg   869040
gataattact gcaataatcg ggggtccagt acttatttat gtaactatga aaaatagagg   869100
ggttaataac taatgcaaaa tttaattata ggtattcaaa aaagaaaaaa tagaataaca   869160
ctattttcct cactattttt attaataata atcagtctat catttttcat tttacttatc   869220
ggagatgaaa gttattcttt ttcaactttg attaaagtct taaatagtga aactgttcct   869280
ggagctagtt tttcgattat ggaaattaga ttaccaaaat tattagcagg aattatagct   869340
ggctggtctt ttggattggc aggatttatc tttcaaacta tgttaagaaa tcctcttgca   869400
agtcctgata taatcggtgt cacaagttct tcatctattg cagcggtctt ttgcatattg   869460
gtattaaaaa caaatagttt aactactgga attatttcaa taacttgtgg actaacatca   869520
tctttaatat tatttttact agctaaaaaa gatggttttt cagcagcaag actgataata   869580
ttaggtattg gttttcaagc tgtcacaaga gcaggcacct catttttatt gttgaaagta   869640
gcaagatatg aattacaaga agttatgaga tggctcagtg gctctttatc ttttacaaag   869700
ttagatgaca tacctcttgt tctaatagta agtattattg ctactatatt agttttattt   869760
tttaataaaa gactagaaat tattgaactt ggtgaagaaa tagcaatcgg acttggagca   869820
aatcccgagc tttcaaggct tgttttaatt ttttgcgctg tatctttaac tgctttttct   869880
acttcaatta caggaccaat agcttgtata tcttttttag ctggtcccat agccttaaat   869940
attggcaaga aaagaagccc aatattagct ggattggttg gaattttact agttttgtta   870000
tcagacatat tctctcaaaa tattttacca gctagatatc cagtaggtgt tgtaactggc   870060
ttgttaggtt caccatactt aatatactta ctaataaaaa tgaacaggag gaatatataa   870120
tgaaaggtct gtggtcaaat aatcttacct gcggttatga tgaaaaaata atcttggaaa   870180
atataaatat aaaaatacct gaagaaaaaa tatcagttat tattgggtca aatggttgtg   870240
ggaaatcaac actcattaaa accttgtctc gacttataaa gccattagag ggagaagtat   870300
tgcttgataa taaatcaatt aattcttata aagaaaaaga tttagcaaaa cacatagcta   870360
tattacctca atctccaata atccctgaat caataacagt agctgatctt gtaagccgtg   870420
gtcgtttccc ctacagaaag ccttttaaga gtcttggaaa agatgacctt gaaataataa   870480
acagatcaat ggttaaggcc aatgttgaag atctagcaaa taacctagtt gaagaacttt   870540
ctgggggtca aaggcaaaga gtatggatag ctctagccct agcccaagat acaagtatcc   870600
tacttttaga tgagccaact acttacttgg atatctcata tcaaatagaa ctattagacc   870660
tcttgactga tctaaaccaa aaatataaga caaccatttg catgattttg cacgatataa   870720
atctaacagc aagatacgct gattacctat ttgcaattaa agaaggtaaa cttgttgcag   870780
agggaaagcc tgaagatata ctaaatgata aactagttaa agatatcttt aatcttgaag   870840
caaaaattat acgtgaccct atttccaatt cgcctctaat gattcctatt ggcaagcacc   870900
atgttaactc ttaataattg aatattggaa ttcatttaaa agtcgcaaat tttgaactga   870960
ccctcaaaag ttaggccaaa aaactaacta aaggaggtca gttttttaat ggcaaataca   871020
gcacagaatt taagataaaa ttagtaaaag aatatcatga atgaaaaata ggatatagag   871080
aataacagca atattaaaaa gatcaggact gataataaac aaaaagaaag tacaacgact   871140
agttcaaaag ctaaaacttc aagtaaaaag ttattcaaga aaatctagaa aatactcatc   871200
ctacaaagga caggtaggaa aaatatcaga caacaaaata aaaagaaata tttattaccg   871260
aaaaaaaggg gaaatcgagt taagtaccaa caggctcatc tattccaaaa agatatttac   871320
tcgatggaaa aactcctaga attagtgcta caaatattga caatggtatc ttaggttact   871380
acgaagatat agatgataaa aattatagag tttttgaaaa ttttatatct gtttcatttt   871440
taggagcagt cttttatcat aaatataaag caagcctaga tatgaaaatt cattgtttaa   871500
aattaaaaaa taaagaattg aataaagaag tagcattcta tttaacttca attattaggc   871560
aagctttaaa aaatactgaa tataaagatc aaatatctag cacagtattg ccagatatca   871620
aaattaaatt accgatagac agtagaggta ctccagattg gaattacatg gaaagatata   871680
gagatagata aagagagaga gggagagata gataaaaagt ccacccccat tttttatgga   871740
gaattcaaaa atgtaaggtt aagcaaagaa gaatataaaa atctaaaaga aaaattaaac   871800
tcacacacag atataatgat aaataaacta tccagataca tggaaagcag tggtaagacc   871860
tatcaaaacc actatgtgac aatcttaaaa tggtatgaag aagataaaga caaactaaga   871920
cagaaaggtt taaataaaaa aatgaattat gatgtaggag aatctttata gataaaaaga   871980
ggtggaaagg cactattaaa gactttaagt ctaaaaaggt atcaaagtat gccagagata   872040
aaaaaatata aatatgacac tttaaaggcg attagaaaat taaagaaatg ctagaagact   872100
tttagatgac agttaccaag agggtctaat tttcactgct atttatgcag tgggaattgg   872160
acctttttat ataagcaaat tctatttcaa aattggttac caagaaagac ttcttttcac   872220
tgttaagtat aagagggtaa tttatagaat tttgttacat caagataaat attttctgat   872280
ggtcaaattt taaaaagatt aataactctc gataaatttt gaaccttaac aattgaatag   872340
accaagacaa gacgttaatt atttttggag cgtaataacc tatccgtcaa gatctttcgg   872400
ctgaataatt cggcaaaaaa agttctgcta agcaaaaaga aagtgagcga taagtaagag   872460
tttgaatata gggagggata ccctatccgc tatgaagaaa atgagggtaa tgatacttct   872520
aaggttgaag ccggctcatc cggaatagag gcggaagtga gattcctatg ttgctaatcc   872580
aaagcacttg tcaatgtcaa aaaacttaat taaacaaata attattagat ataaaacttt   872640
agaggaggta tatattggac aatgactgga atggattggc tgatttaata gcaaatctga   872700
ttgcaaaata tgctggtgct ttagatttag ataatctacc cgatccaacg ccagcaaaaa   872760
atcaagagat gaaaaatagt tttgacatgg caaaaacaca aattgagacg gactaataaa   872820
agtgttataa tatacttgaa atgatagtcc aaacttaaat taaaaaaatt atatatgata   872880
tagaaaaatt atattgaggt taatactatg tcaaaagaaa aaataaaagt atacctctat   872940
acacgagtat ctacgtcaat acagatagag gggtattcgt tagaggcaca aaaatcacga   873000
atgaaagctt ttgctattta caacgattat gaaattgttg gagagtatga agatgccggg   873060
aagtctgaca agtctattga aggtagaata cagttcaatc gaatgatgga agatataaaa   873120
tctggaaaag atggagtatc ttttgttctt gtgtttaagt tatcaagatt tgcaagaaat   873180
gccgctgatg ttctttctac acttcatata atgcaggatt atggagttaa tcttatctgc   873240
gttgaagatg gcattgattc atctaaagat gctgggaaac taatgatttc tgttttatca   873300
gctgtggctg aaatagaaag agaaaacatc agtattcaaa caatggaagg tcgcattcaa   873360
aaagcagggg aaggaaaatg gaatggtggc tttgctccgt atggatataa acttgaagac   873420
ggcaagctgt ttataaatga ggaagaggca gttgcaataa gaacgatttt cgaccagtat   873480
gtaaatacta cgataggagc caatgggata tctaaatact tagagaatca tggaattaga   873540
aaaatcccaa gacagaatgg taagaatcct ttgtttgatg caggtcttat aagaaagata   873600
ttaaagaatc ctgtatataa tgggaaaata gcatttggaa gaagaacttt agaaaaagtt   873660
catggtacaa gaaatgaata taagcaggtt gaacaagatg aatatctaat atctgaaggg   873720
atacatgaag ctatagtttc cgatgaagtt tggcaagctg ctcaggttaa gctaaaatct   873780
caagcaaaga aatatgagca tgtgaataaa ggaaaagata cacgcacaca cttgctttct   873840
ggaattgtaa aatgcccgat atgtggagtg ggaatgtttg ggaacaagtg tatcaagaaa   873900
aagaaagatg gcacaaagta taaagatttt tattactatg gttgtaacca taggcagatg   873960
ataagaggta ataagtgtac attcagtaag caaattagag aagaattgtt agatgatgct   874020
gttgcagagg tgattgtcaa gatagtaagt aatccgaaat ttgcttctat gatgcaagaa   874080
aaaatcaaca tgaaggtgga tacctctgaa atagaaaaag aaatagataa ttaccaaaag   874140
gaattgagaa agagtcattc tacaaagttt aagctaattg aggaaataga taatttagat   874200
gttgaagata agcattataa gagaaggaaa caggatttag atgatagact atatcgtatg   874260
tatgacaaac tagatgaatt agaatcatca ctaattgatg cgaaagcaaa gaaacagact   874320
attgaagctg aaaagcttac aggagataac atatataagg ttctgatcta ttttgataag   874380
ctctataaag tcatgaatga tgtagagcgt aggcagttaa tttcagcttt gatttctgaa   874440
attcaagttt atgaagaaaa acaatctaac ggacaatggc taaaatccat tacttttaag   874500
ctaccaatta tagaagaaaa tctcaacata ggtttggaca atgatgaaca agttgaatgt   874560
gtaagtttat tagagaaacg tagttaatcc tcaaaaggtt ccccgaacct tttgagtccc   874620
actgacgcat cacgctgagg cggtatcact gcttgtacga gttgaagcat cagcaaagta   874680
aaagtagatg ttcagccaat gcgacgaggt gagaccgaag gtcgataagg tgtgttctgg   874740
gtataagact cgtaaagtaa gtaggaaata tgatgagatg atacagagag cctgaattgg   874800
tcaggtgacg tgcttattta cattagcctg ataatgaaaa tggagagatt atcgatggtt   874860
atattggaat tgtaccaaaa tgattattct aaagatttag tagcatttga ttccatagaa   874920
gatgggaaag cctttgtagc tcaaatcccg ggatacactc tggaaacaga agatggtttt   874980
gaagtggagt attttaatcc taaaaacata ccggattata tggaaattat ttttaacgga   875040
aatattgttc ctttatctaa atttatgttc gatcctgagg aaaatgtaaa cattatttgg   875100
aaagagattt caaatttatc cctcaaaaat gatagagtga tcgaaggata ttcaaaaatt   875160
gatgcatatg tcgttaacaa ccatgaagtt aaagcctatg tcgaaacaag agaaacgaac   875220
tatcgtaaag caaaagactt cttagaaagc cgcggatatg aaatcgacag aagctttttc   875280
ggaagtgaag acggtgaagc gattctttac agaaaaaaag ggatcgaagt ttggcatttc   875340
ttgtgtcact tagacccaat gtttgtagag attgaagatg tagaaggata tgttaaagaa   875400
gaagttggag agattcaata gtcaaccaaa gttccttgtg agtatatacc tttgctagta   875460
aaagagtcaa aacgttataa cgaagggggg gaagaaaacc cttgagtgta agtctttttc   875520
ttgtttagag ggaaagtatt agagtagccg ctcataattt atactagatt tgataactga   875580
tttgagacag attttatttc tataaatatt gtgaaaattt tttaatacca aagatttaaa   875640
gttactgtgt taaaaatcct ctccactttt aaactaatgt attataaaag ccagttgaca   875700
ctagtgttac acctgtgata gaattaactt gaggtgatga aaatggcaac cgataaaaat   875760
agaataatga ttagcttgga tgataaaaat ctagagaaac ttgaaaattt agtagaagat   875820
gctagagata gaaggggaat gcgactaaca aagtcccagg ttattgaatt actcctaaat   875880
accgttgatt atttcgatga tattatgggg gctatttact caaaaaaata agagcaaaat   875940
tgctattatt ttttacaaat tggtgtaaca ctagtgatat aggagtgatg aaatggttgt   876000
ttatattaga caaagtaaat taccaagtga ggtttcaatt aataaataca atgctcaagt   876060
aggtgcctac ttacaaggag aagaagttat tttatatcaa tctttttctg aaataaaaga   876120
gttaacaagt gaagatatag ttgtagatta tataatggag actagagcat tactaaaaat   876180
gatgggctta aacgttccgg ttcatgacta tcctattgag cttaaagagt tttatggtcg   876240
aaagatttat gctggtattt taggagagat tgtgaatata cctgataatt ggggaaaatt   876300
tattaagcct aaagctggtt caaaagtctt tactggaaga gttgttaatg gaacccatga   876360
tttaataggt attggtctac ctttcgacta tcctatatgg attagtgagg ttgtagaatt   876420
catagctgaa tggcgttgtt ttgtgttaga tggtcgcgta ttagatgttc gaccctatac   876480
aggtgattat catgcacaat ttgatgcaag tgtaattgat gaagcgatat catgttggaa   876540
agatgcgcca atagcttatg gactagatat cggtgttact cgcgatggca gaacacttgt   876600
tgttgaagta aatgatggtt atgcattggg aaattatggc ctatctcctt taaaatcaat   876660
caattttcat agagctaggt ggaaagaaat ggtaaaaccc tattttgaaa aaaatgaaat   876720
ttttaaaatc caacaggatg ttattttcta aaataaatat ggtagataac caatataaaa   876780
agcatcaaaa tgaacaagga ggaatctgat gcttggagca attattggag atattgtcgg   876840
ttctgtttac gaatggaaca atatcaaaac aaaggacttt cctttatttc ggaaggactg   876900
cttttttaca gatgacacgg ttatgacctg tgctgttgca gaagcaatta tgaatggtgg   876960
acaaaaagat gacttcattg acgcgatgaa gaaatatggc agaatgtatc cgaatgctga   877020
ttacggtgct cggtttaatg catggctaaa cagcgataac cgtgagcctt ataatagctt   877080
tgggaatgga tcagctatgc gtatttctcc atgtgcttgg atcatggact gtggttttta   877140
tgcgaaaact ggtatatggc catcatctag aggacttacg agtctttctg cagaggtaac   877200
tcataatcat ccagaaggtg tcaaaggcgc tatggctaca gctgatgcta tctttctatg   877260
tcgtttttac tttggtggtt attgtagaga gtacgagcaa tcaattaacg acaatcctac   877320
agagtgtaaa agacgaatta aggattatat agaaaaagaa tacgattaca atctatctca   877380
aactttagat gaaatccgtc ctaactatcg ttttaacgaa acatgtcagg aaactgtccc   877440
tcaagccatt atcgcctttc ttgaaagtag agacttcgaa gatgcgataa gaaatgccat   877500
ctcacttggt ggcgacagtg atactctcgc agcaatcact tgtagcatag cagaggcagc   877560
ttacggtatt cctgattgga tcaaggataa ggcctattct tacttggatg aacccttaaa   877620
ggatgtagtt aggcgatggg aaaatagaat aaaagcgtat taatctccag tacgtcagat   877680
ttctcttttc tgtattttca ttgtataata ggattacatt tacttgcata cgacgaaatg   877740
taaacatttc tgtttaaaat taaggataaa atcaatgaaa aaagcaatgg taattatcaa   877800
ccctacttct ggtggcgaga aggctttgga ttacaaagaa aagctggaga ataaagcaaa   877860
agaatacttt gaatatgttg aaaccaaaat taccgaaaaa gcgctggatg caacacattt   877920
tgctgaagaa gcttctcgtg agcagtatga tgcagtggtt gtgtttggtg gagatggaac   877980
tgtcaatgaa gtcatttcag gtattgatga gagagactac attcctaagt tagggattat   878040
cccaggcggt acgggtaacc tcattacaaa acttttggaa atcaatcaag acatcgatgg   878100
cgcaattgac gaactggatt ttgatttaac caataagatt gatatcggta aagcaaatga   878160
caactatttt ggttatatct ttagtatcgg ttctctgcct gaggcgattc acaatgttga   878220
aatagaggac aaaacaaaat tcggtatttt aacctatgct gtaaatacca tgaagtctgt   878280
catgacagat caggtcttta acattaaggt tgagacagaa aatggaaatt atgttggtga   878340
agctagccat gttttggtcc ttttgacaaa ttacttcgct gataagaaaa tctttgaaga   878400
aaacaaggac ggctatgcca acattttgat tctgaaagat gcctctatat tctccaaatt   878460
atccgtcatt cctgatttat taaaagggga tgttgtcgca aatgataata tcgagtatat   878520
caaagcgcgt aatattaaaa tctcttcaga tagtgaattg gagtcagatg ttgacggaga   878580
taaatcagat aacctacctg tagaaatcaa agtcctagct cagcgagtag aagtattttc   878640
aaaaccgaaa gaggattagt atatagagaa agcctttttt aaggcttttt gtatacttta   878700
aaagatagtt cctttaacaa cggacattcc ttgcaaatag ttttacaaaa atagtatact   878760
ggattcattg agtttgaaaa cgtttgcgta aaatttgaat gaatacttta ggagacaaat   878820
tgatggaatt gagtgctatt taccataggc ctgagtcgga gtatgactat ctttataagg   878880
ataagaaact ccatattcga attcgaacta agaaagggga cattgaaagc atcaacttgc   878940
actatgggga cccttttatc tttatggagg agttttatca ggatacaaaa gaaatggtca   879000
agataacttc tggtacctta tttgaccatt ggcaggttga agtgtcagtt gactttgcac   879060
gtatccagta tctctttgag ctcagagata cagaaggtca aaatattttg tatggcgata   879120
aagggtgtgt ggaaaattct ctagaaaatc ttcatgcaat tgggaatgga tttaagttgc   879180
cttagcttca tgagattgat gcctgcaagg ttcctgactg ggtttcaaat acggtatggt   879240
atcagatatt tcctgaaaga tttgccaatg gcaatgctct attaaaccca gaagggactt   879300
tagactggga ttcatctgtc acacctaaga gcgatgattt ctttggtggt gatttacagg   879360
ggattattga tcatatgaat tacttgcaag acttgggtat tactggacta tatctttgtc   879420
ccatctttga atctacaagc aatcacaagt acaatacgac agattacttt gaaattgacc   879480
gtcattttgg agacaaggag acctttcggg aactggtgga tcaagcgcat catcgtggca   879540
tgaaagtcat gctggatgcg gtatttaatc atattggttc gcaatctctt caatggaaaa   879600
atgtcgtcaa aaatggtgaa cagtctgctt ataaggattg gttccatatt caacaattcc   879660
cagtgacaac tgaaaagcta gttaataaga gagacttacc ctatcatgtt tttggtttcg   879720
aggactatat gcctaagcta aatacagcca atccagaggt caagaattat cttttaaagg   879780
ttgcgactta ttggattgaa gagtttaata tcgatgcttg gcgtttggat gtggctaatg   879840
agattgacca tcagttctgg aaggattttc gtaaggcagt tttagctaaa aatcctgatc   879900
tttatatcct aggagaagtc tggcatacat ctcagccttg gctaaatgga gatgagttcc   879960
atgccgtcat gaattatcct ttatctgata gtatcaagga ctatttctta cgaggaatta   880020
agaagacaga ccagttcatc gatgaaatca atggagagtc tatgtattac aagcagcaga   880080
tttcagaggt catgtttaat ctcttggatt cacatgatac agagcgaatc ctgtggacgg   880140
ccaatgaaga tgttcaactg gttaaatcag ccttagcctt tctcttttta caaaaaggaa   880200
caccgtgcat ttattacgga accgagctag ccttgactgg aggaccagat ccagattgtc   880260
gtcgttgtat gccttgggaa cgtgtatcaa gtgacaatga tatgctgaac tttatgaaga   880320
ggctgattaa aattcggaaa tacgcgtcag taatcatttc gcatggcaag tatagccttc   880380
aagaaatcaa ctctgatcta gtagctctgg aatggaaata cgaaggacgg atcctcaaag   880440
caatattcaa ccaatcaaca gaagattatc ttttagagaa agaagcagta gcactagcaa   880500
gcaattgcca agaattggat aatcagcttg tcatctctcc agatggattt atgattttct   880560
aaaaactagt tgatgaagat tatggtacat ttcatacctt atatagtata ataaggctag   880620
ttactaaact tgtaaaggag aacttaaatg aattgtagag gacatgaaac aagacaaaga   880680
attgttagag attttgaagt tcagcctaaa gcacatatta agctgttagc aaatcaacaa   880740
aaacatagtg atgcaggagc aactattgaa gatgaatatt atgtatttat cgctgagagt   880800
aaaattgatg gcaagaagga agttattcag tgttgcatgg gtgcggcaag ggatttttta   880860
gaactaatta atcacaaagg gctacctctt tttaatccgc ttgtaggtga ttctcatgta   880920
aataatagac aagaatatga caatacaggg agtggaaatt tataacctga aaagtggaat   880980
gaaactgcaa agcagcttta taatgctata atgtggttga ttattttatg gaatgctaag   881040
ccggatacac ctttatttaa ttttaaagac gaagtaatta agtataaaac atatgagcct   881100
tttgaaagca gtataaaaag agtaaatact actataaaga atggtagtaa agggaaaact   881160
ctgactgaga tgattaatgg ctacagagcg gataacgata ttagagatga aatttgtaac   881220
tttaatattc tgaaaaataa aattcgtgat atgaaaaacc aacaaggaaa tacaatggaa   881280
tcttactttt agttattgtt gaattttggg tattctataa aatatcctaa ttgagattta   881340
aatagtagac tatacaatat agttaaaata tcagtaaaaa caacacttta ttgaggtatt   881400
ggatacgctt tgctaatagc ctaataatca catgtggagt gttgctacaa cgaaaaaggt   881460
gataatcctt gatttcaagc tattttataa gcattttgtc tttgtagata aaggcaattt   881520
tgacaataaa aatcctaaaa ggtgaatcgt tatagatgta tttgtagata tcgtttgcgc   881580
atcgaaaaaa ttaatacaag aataaatatt tatagctctt taggtgactt ttatagaagt   881640
aaagtttagg atagaaaaac aagaaataac gcaccatttt tggtgcgtta tgctttttta   881700
tgctataatg gatttataaa aataaaggag tttgctatga ttggaaagaa cataaaatcc   881760
ttgcgtaaaa cacatgactt aacacaactc gaatttgcac ggattgtagg tatttcacga   881820
aatagtctga gtcgttatga aaatggaacg agttcagtct ctaccgaatt aatagacatc   881880
atttgtcaga agtttaatgt atcttatgtc gatattgtag gagaagataa aatgctcaat   881940
cctgttgaag attatgaatt gactttaaaa attgaaattg tgaaagaaag aggtgctaat   882000
ctattatctc gactctatcg ttatcaagat agtcagggaa ttagcattga tgatgagtct   882060
aatccttgga ttttaatgag tgatgatcta tctgatttga ttcatacgaa tatctatcta   882120
gtagaaactt ttgatgaaat agagagatat agtggctatt tggatggaat tgaacgtatg   882180
ttagagatat ctgaaaaacg gatggtggcc taatggaaat ccaagattat actgatagtg   882240
aattcaaaca tgctttagca aggaatcttc gttcactgac aagaggaaaa aagtccagta   882300
agcaacctat agcgattttg cttggagggc aaagtggtgc cggtaagact acaattcatc   882360
gtattaaaca gaaagaattt caaggaaata ttgttatcat agatggtgat agttttcgtt   882420
ctcagcatcc acactattta gaactgcagc aagaatatgg caaagacagt gtagaatata   882480
ccaaagattt tgcaggaaaa atggtagagt ctttagtaac aaaattgagt agtttgagat   882540
acaatctttt gatagaggga actttacgaa cagttgatgt tccaaagaaa acagcacaac   882600
tcttgaaaaa taagggatat gaagtacaat tggccttaat tgcgacaaag cctgaattgt   882660
cgtatctaag tactcttatc cgttatgaag aactgtacat tatcaatcca aatcaagcac   882720
gcgcaactcc aaaagaacat catgatttca ttgtaaatca tctagttgat aacacacgaa   882780
aattggaaga actagctatc tttgaaagaa ttcaaattta ccaacgagat agaagttgtg   882840
tatatgattc aaaagaaaat acaacttcag cagcagatgt tcttcaagag ttactctttg   882900
gggagtggag tcaggtagag aaggagatgt tgcaggtggg ggaaaagaga cttaatgaat   882960
tacttgaaaa ataaacaatt gatattttta ggagaataga aatgagaggg tttaataaca   883020
agataaagtc tgtttatcaa gaactaacaa attccaaaga gaaattcggt agctttcaca   883080
agactttaat tcatttgcat acacctgttt cttatgatta caagctattt tctaattgga   883140
ctgcaacgaa atatagaaaa attactgaag atgaactata tgatatattt tttgaaaata   883200
agaaaataaa agttgataag acaatttttt ttagtaattt tgataaggtt gttttttcta   883260
gttcaaaaga atatattagt tttcttatgt tagcagaggc aatcataaaa aatggaatag   883320
aaatagttgt agtaactgat cataatacta ccaaaggtat taaaaagtta caaatggcag   883380
tctcaatcat aatgaaaaat tatccgattt atgatataca tcctcatatt ttacatggag   883440
tagaaattag tgcagcagat aaattgcata ttgtatgtat atatgattat gaacaagaat   883500
catgggttaa tcaatggtta agtgaaaata ttataagtga gaaagatgga agttatcaac   883560
attcactgac tataatgaag gatttcaata atcaaaaaat agttaactat attgctcatt   883620
tcaatagtta tgacattttg aaaaaaggtt ctcacttatc aggtgcatat aaacgaaaaa   883680
ttttttctaa agaaaataca cgattttgga gtttaatatt aactcgaaag aatcttcgca   883740
acaacttgat attctctata aagaagttgg tgtattaagt ttgggacaaa aagttgtagc   883800
catgcttgat tttttattag catatagtga ttattctaaa gacttcagac cattgattat   883860
tgatcagcct gaagacaatc tagacaatcg ttatatttac aggcatttag ttcagcagtt   883920
tagagatgtg aaagctcaac gtcaaattat tttagcaaca cataatgcta caattgtaac   883980
aaattctatg acagatcaag ttgttattat ggagtcagat ggagttaacg gatggattga   884040
atcacaggga tatgttagtg aaaaatatat aaaaaatcat atcatcaatc aattagaggg   884100
aggaaaagat tccttcaagc ataaaatgtc tatatatgag acggctttat cagagtagag   884160
tcagaaaaag taggttagaa atttagccta cttttttctt tgtccgacag gcatagtgta   884220
catctgaggt ccaagtcctc tgtggatatt tgctgcagat gaaaccaata gcgactccta   884280
agcctgaata tcgtgaggta ggggggatag gaaggaatta gcgaaatcaa ggttctacaa   884340
acagaatcgt gacttgaagc catatatagc ggatgaggaa ctctaaaatc caaataggtg   884400
tcgtaaccta tatacgtaaa ttacgagagt aaactaggaa agatgtacgg cttattccgt   884460
gagcgtttag gacgtagtac aacgaatcat gggagtcagc tgaacacata gtattgaaga   884520
aatttctgta atggaaatgg agcgaagaag tgaacaatta aatgaatacc tctctaatta   884580
aatttgtcaa ttctaattcc tggtatgaaa agacagtgac ctgaaaatgt aaacgatggg   884640
agctgatcat aaatatagga cggtacatgc agtggtgtta gagattagtc cttacttgat   884700
ttgtgataac ttccccaaat ttcttctgct atacttttct caacttttaa aaatccaact   884760
aagaatttta cctgggggtt tgggggcgga gcactaagtt atcttatcgt tagctgtcaa   884820
aactggtagg ttttgatagg ctggcgatat gatttttggg atattgtgga cacaatatct   884880
gagctcgcaa agccttacaa gaatgaaaat cagttgttgg aaaagtgtac tgacattgta   884940
tggtagctca cattgtcagt acaagtattt tggaaaggaa gtagcagtat gaaacgagat   885000
gtgcgtgata ttcggaaaca atttcgttta acagaagcag aagaaaagca aattctagct   885060
ttgatgagag agcggggaga gactaatttc tctgattttc ttcgtaaaag tttactttcc   885120
tctgatttac aaaaacagat ggagacatgg tttgccctct ggcaatccca aaaactagaa   885180
caaatcagtc gtgacgttca tgaagtttta atcttggcac agtcagaacg tcaagtcacc   885240
caagagcatg tatctattct cttaacgtgc gtgcaggaat tgattcaaga ggttgcaaac   885300
accatacccc tcagtaaaga atttcgtgag aagtacatga ggtaagcaca tggaacatcg   885360
ttaccgaacc aatctcaaga aagtgttttt gtctgatagt gagttgaacc aactaaatat   885420
aaatatcgat caaagtggtt gtaaatcctt ttctgaatat gcgagacgaa ctctactcga   885480
tcctggtatg aattttatca cgattgacac aaacggttac caagatttag tgtttgagtt   885540
aaagaggatt ggcaataata tcaaccagat tgctcgaagt gttaatcaat ctcagttaat   885600
ttctggtgaa gaattgcagg agttgaaaaa aggaattggt gaattgataa aagaagttga   885660
taaggaattt aatctgcaag cgcagaagct aaaggagttc catggtcatc actaaacact   885720
ttgccattca cggaaagagt taccgcagaa agcttatcaa gtacattctc aatcctgaga   885780
aaaccaataa tcttgccttg gtgtcggact atggcatgaa gaattttctg gactttccta   885840
gctatgagga aatggtgcag atgtatcatg aaaatttcat cagcaacgat acgctttacg   885900
attttcgcca cgacaggatg gaagaaaatc aacgaaaaat acacgctcac cacatcattc   885960
agtctttctc gccagaggat catatcactc ctgaacaaat caatcggata ggttatgaga   886020
ctgtgaagga attaactggt ggcaaatttc gttttatcgt tgcgacccat gttgataaag   886080
accacctgca caatcacatc attatcaatt cagtagatag caattctgac aaaaagctca   886140
agtgggacta caaggtggag cgaaatcttc gcatgatttc tgaccgtttt tctaaaatcg   886200
caggtgctaa aatcattgag aaccgctatt ctcaccagcg gtatgaagtc tatcgtaaga   886260
ctaatcacaa gtatgaactc aagcagcgac tctatttttt gatggaacat tctagggact   886320
ttgaggattt caaaaagaat gctccgctac tacatgtgga gatggatttc cgtcacaagc   886380
atgccacctt ttttattacg gactcaacta tgaaacaggt ggtgcgtggc aagcaactca   886440
atcgcaagca gccttacaca gaagaatttt ttaagaacta ctttgccaaa agagaaatag   886500
aaagtctcat ggaattttta ttgctgaaag ttgagaatat ggatgattta cttcagaaag   886560
caaaactttt tggactaact atcaatccta aacaaaagca tgtttctttt caatttgcag   886620
gagtggaggt aaaggagaca gagctagacc agaaaaatct ttatgatgta gagtttttcc   886680
aagattattt taaaaataga aaagattggc aagctccaga aactgaggat ttcgttcaac   886740
tttatcaaga agaaaagtta tccaaagaaa aagaacttcc aagcgatgag aagttctggg   886800
agtcctatca agagttcaag agtaacagag atgccgttca tgaatttgag gtggagttgt   886860
cactcaatca aattgaaaaa gtagtggatg atggaattta cgtcaaggtc aagtttggta   886920
ttcgtcagga gggacttatc tttgtgccga acatgcagct tgatatggaa gaggataagg   886980
tgaaggtttt catcagggaa accagctcct actatgtcta ccacaaagac gctgccgaga   887040
aaaattgtta tatgaaaggt cgaaccttaa ttagacagtt cagctatgaa aatcaaacca   887100
ttccattacg cagaaaagcg acagtcgata tgattaaaga gaagattgcg gaagtggatg   887160
ctttgattga actggaagta gaaaatcaat cttatgtcac gattaaagat gagttagtgc   887220
atgaactagc agcgtctgaa ttgagaatca atgagttgca agaacgaatg tcaaccttga   887280
atcaagtagc agaatatcta ctggcttcag ttgaaagtaa gcaagaaatg aaattaaatc   887340
tttcaaaact gaatataact gagaatatca gtgctaatat tgttgagaaa aaattgaaga   887400
gcctggggaa tcaactggaa ttggaaaggg gcaggtatga aaagatggta gtcaggctag   887460
ataaatttat aaatcgctta aatacaggac tttcaaaagg agatgggata gattttcaaa   887520
aataggaatc tagccaataa ttatatacaa tgtgtatctt ttgtaaaata tatttgaaat   887580
ttagatttaa tcatgttaca attaacattg aaatcaaata gaaaaggaag atgcaaacgt   887640
gggtacacta ttagcaacaa gattaaaaaa tagacgaaaa gaattaaaaa tgtctcagcg   887700
agaattagct gagggtatct gtaaacaggg gcaaattagt cgattagaga gtggagagtt   887760
cacccctgga gcggattttt tacatgccct tgctaagaaa ttaaaagtta gtatggacta   887820
cttttttgat gagcaggttg tagaggaagt caatgagtta tcagagttta agaagttagc   887880
acagacattt atcacaaatc gtaattatga atctttaaaa tatatatatg aattggaaaa   887940
tgtaaaagcc catcgcttat ctctagcaga taaattttac atggaatgga taaagtctct   888000
tatagatttt tatttttatg gacagaaaga agaggcaatt acacgattag agaatatgct   888060
acctcagtta aatgtatctg atttgaacta ccttcaagtt tcaaacactc tattcaattt   888120
ttattatgat attgaagatt tagaacgttt taatgagatt agagacaagc tagagcatca   888180
agtgaatcag cttaatttaa acacaattga agagttagaa ctatcaatta agttcaatta   888240
taacgtttgt cgatacctat ggttacagaa aaatattgaa gaagctatta cgaaaatcac   888300
agctacgata aagcaatgta aggagtacag gacaacttat ctattagctg atttgtattt   888360
attgatggga agtgtaagtg aaaatttttc ttctaaaagt tcagtaaaag aatattttga   888420
gactgctcat tttctctaca aacttgagga aaacatgtca atggctttga aagtcgaaca   888480
ttattttgca gatataacag aataaggaat acggtgttct agtgagcatc gttttttaaa   888540
tctaatttga atacaaaaaa gtattaaata aaaaaaaata aaaaaagatt ataaaaatac   888600
ttgacaagct aattttgaag tgataaaata aatgcaagaa aacgaaagga gaggtatatg   888660
agaagtttgt ttaggaaaat tgttgctttg ttagtcatag gattaatcct attagggact   888720
gctggaggaa ctcaagttca taagatggct agagggattg atccaggtcc tgcgaatggt   888780
atttatagat aggagattat agtcacttaa aaatcaaaaa attataaaat ttttgtttta   888840
cttaaataga tattttatga tgggcgaagt ttttataact agttcctata agtacagaaa   888900
cctattttaa tttactaatt tcaaaacaat tttttgagat atatgtaatt aaatctaaat   888960
taagctttaa aaaattattt ttagcaattt gattttgaaa gtgtcatgca gcaatatgaa   889020
agcgtagaat agaggtgttt ccaatgtaca agtaagtttt gattccaaat aaagtaatag   889080
aaaaggagct atataatgag tagtcaaatg aaagctttct tgaatgaact tcaaggaaat   889140
atggaagttg ttggagaatt ttttgataat cctgaaaagg taattagaaa atttggaatt   889200
gtcggaagag agaaggaagc attgctaatc cgtgacttaa atgatatgga tgattatgct   889260
ctttcaattc aaaatagcgt tgcatcgcct tctggggcac atagtagcac ttgccatttt   889320
gttagacaag atttacaatc cgcataattg ttaatatata aaacataaaa tttcaatttt   889380
caattaggga taatagaatt ccttactatg atatagaaag tgaattaatt aggaaatctt   889440
agtcagaggt ttctgattaa ttcatttttt atatattaag agtgatgtga aatgttcaaa   889500
ttgtgagact actctcggat tgttgtatag aaatttaaaa ttttattgtg agctttttaa   889560
ggaagagtgg ccgatatgaa aaataaatac gatgttaaaa gaattattcc ggatgaatta   889620
tcagaatcac tagatatttt tctaaaaaat tattctgaaa ctggattgtc agattataat   889680
acttatctct tttatggttt tatcttgaag tcctataaat tgcctcgaga aaatagatat   889740
agcataaaat tattggtgaa ggaattacaa aatagaggac tgaaagttac attgattatc   889800
aacatttatt atcacgcttt aaattgtttg gctttaaatg atggtctaaa aatttatgga   889860
gaagatttct taatatgaat tacgaaaagt atttaaacta tttggactat gaaactgaaa   889920
tagaagacgc ataccataat ttattattag aatataaaat tagtgataat tttagtgatg   889980
aacattggtt atataatttg ccgtctaata tcacccaatc taagggattt aaaatacacc   890040
tgagcgcttc aatattaaat gctaatttgg ttgctaaaaa attctttgat tttatatttt   890100
ctagagagaa gaagataaat ttcaaaattt tggttagcat taaagaactt tctttgcaaa   890160
atacagggct taatggttat tcacaagtcg ggaaattcat tacaatttat ccaaaagata   890220
ataaagagtt tcaacgtttg ttacacaaat tagaaatatt gtataaaggt gtaaagggtg   890280
taaacatacc atcagatttc agatttcaac ttagcgaggt tgtatattac agatatgggg   890340
agttcgtaaa agatagcact ttcaaggata aaagagataa gaaaatccct tcaaatgtga   890400
atgttccaat aagggattac tatattccaa gatataacac tattcctgat caatatatta   890460
ttttggaagt gatttctaaa aatgccaaag gtggagttta taaagtattt aatactcaaa   890520
agcgagttta ttctttatta aaagaagcta gtgatttatc gttggttgat tttacaaata   890580
gagattctgt gaatcgttta ataaatgaaa gagaaatatt agtagaattg gaaaaggagg   890640
aatttactcc aaaagttttt aacgattttt acataaagaa ttcgtatttt gtggaatttg   890700
agtttattat tgcagataaa ttaagcgagt ataatatggt tagtggctcg tatgattggt   890760
ttttaacatt aattgattat atggagataa taaactccaa atataatctt tcctatagag   890820
atttatcatt taataatata cttattgata atagaaataa tatttatatt atagactttg   890880
agcatgccct aaggaaagaa actcaaattg aagaaaaaaa gttgcctcta tttggaactc   890940
cagggtttta tgaaaccaac ttaaatttat tgaataatca accagaggat attatgggat   891000
tggttttgtt attatattgg agtcagaatt tagatgattt taacgtcttt tcaaaaatga   891060
gttttttaga agcgatggag tatgcaatga attttaattc gcgtcgctta gacacacttg   891120
ataaatcaga ttggctttat gatatttata aaaaagcgtt caattataaa tatgatactt   891180
tttctgaatt aaaaaaagat tttatagagg tattaaaata aaggtagggg tgttatgaat   891240
tgtttcttga aaatgaataa tgtaagtgtt cgttatgatg acgtaatagc tttaaaagat   891300
ataactttac aaataaataa gggagatttc attggcttat taggttcaaa tggtgcaggt   891360
aaatctacgt taattaattc tattgtaggt tttcaagaga tttatttagg agaaatagag   891420
tattgtgata aagatttgat agttagttct caaccttttg ctcatttagg ctttactcct   891480
caaaccacag taattgattt ttatactact gtgaaggaca atgtaatatt ggggctgaac   891540
cttgctggaa agtttgggaa aaatgctgag aagttgtgtc aaatagcctt agaaattgtt   891600
gggttagctg ataaaaaaaa taatttggta gaaacattgt caggtggaca actgcaacgc   891660
gtccagattg ctagagcaat agctcataat ccagattttt atattttaga tgaacctacc   891720
gttggtttag atactgaatc tgccgaaaaa tttttaatgt atttaaaaga taagagtttg   891780
gaaggaaaaa ctattatcat atcttcacat gacataaatc tactcgaaaa gttttgtaaa   891840
aaaatacttt ttttacaaaa tggctccata tcattttttg gtgatatgcg tgactttgta   891900
gataattcaa ctatcaaatt aaatttttca atgcagaata gaatttctag atatcaaatt   891960
gaatttttag aaaattttag atttaaagtt cacatcgaag ataatgatag ttttacaata   892020
gaagtcccta tagaagaaaa gatcttagat gttatcaatg aggtaggaaa agcatgtgaa   892080
attaaaaact tttcaacaag taaattaacc ttacaagaaa gttatttgca aagaatagga   892140
ggagaaaaat gaaggctgat caattaaggc acaaatcgga cttaggttta agaggtctag   892200
cgattattgc taaaaatgag attattgctt tttttagaag taaaggttta attatttctc   892260
agtttctaca accaatctta tatgttgttt ttataataat aggattaaat tcttcgataa   892320
agaacattca gtttaatgat ataaaaacct cttatgcaga atatacaatc attggtgtta   892380
tagctttatt gataatcggg cagatgactc aagttattta tagggtgaca atagataaaa   892440
aatatgggct acttgctctt aagttatgca gtggagttcg tcctttatat tatattttag   892500
ggatgagtat ctattctata ttagggttga tagttcaaga aattattata tatataatta   892560
cgttagcgtt tgagataaat atcgcaatgg atagattttt ttatacagtt ttgttatcta   892620
ttgttgtttt attattttgg gactcccttg caattttact tacaatgttt atcaatgatt   892680
acagaagacg tgatattgta atacgttttg tactaacacc gcttggtttt acagctcctg   892740
ttttctactt aatagattct gctcctagta ttgtgagatg gattggtcag ttaaatccct   892800
taacttatca attaactatt ttgagaaact tttattttaa aaattcaaca actttggaat   892860
tagttttctt attgttaaca tcattacttg tccttatatc tgtatctttt attataccaa   892920
agataaaatt gatactgata gaaagataaa agttgggtca tccaactttt ttgttgtctc   892980
ccgaaaacca ctagctatgc tagtggttcc atagagcttt tagcgtggta acaaaaagaa   893040
cctcctaaaa tgataagata gaagtggttt ctccgccact acaacatatc atacaggagg   893100
tacctcatga gagaggataa tcaaagttta tcacatacca catggaattg taaatatcat   893160
attgtttttg cacccaaata tcgtcgtcaa atcatttatg gcagatacaa agctagtatc   893220
ggaagaatca tacgtgactt atgtgagcgt aagggtgtaa taatccatga agcgaatgct   893280
tgttcagacc atattcacat gcttatcagt attcctccga aacttagtgt ttcgtccttt   893340
atgggctatt taaagggcaa gagcagtttg atgatttttg ataagcatgc gaatttaaaa   893400
tacaaatatg gcaatcgcaa gttttggtgt agaggctatt atgtagatac ggtaggccgt   893460
aatcagaaag tgatagctga atatattcag aatcaattac aagaagacag agtagcagac   893520
cagctcacgt tattcgagtc agtagatccg tttactggcg aaataaataa gaggaagtaa   893580
ctaaggtgct ttagcacctg ctcgggaaag tggtgcgcga ggaagctatt tcggtgggcc   893640
tttggccctg gccggtagaa gcggcttata gccgcagaac aaaccaccag ttcacactgg   893700
tggttttgat ttaaaaaact tgatacataa aaataaaagt ctatataaag gatggtaaaa   893760
ttcctgttgt ccgatttgga caatatccta aatagttaca atatatggtc tatacttttt   893820
cttaggagaa agctagatgt acagacgttt gagagatttg agggaggatc atgatctgcc   893880
ccaaaagcaa atagctacaa tactttcgtt tacaaattca gcttatgcca aaattgaacg   893940
gggtgagcat gcgttgacgg ctgatgtatt ggttaaactc tcagatttct atgacgtcag   894000
tacagactat ttattgggat taactgattt tcctgataaa attcgcttta gaaaataatc   894060
tcctcaattt catagagttt gaaaatgagt gagatttttt atttgccctt tgacaactga   894120
atagcctaaa atggtacttt cctcatttgt ggagcaaatt tgaatggctc gccatgataa   894180
gagcgatttt aaaatcatca ataaaataga gcgatacttt atatgccatg atacaaatga   894240
tatacaatga tacttctgac cgttcagcct gccaacgtaa aagagcagca agtgaaattc   894300
ttatgatgac ttcatcagtc atgccacgtt gaatgtgtga gtttgttaga taaacgcaat   894360
taatcctcaa aaggttcccc gaaccttttg agttctacag acgcatcacg tggagtgtgt   894420
aagcttgttg ctaaaagcgt aaaaaccttg gaacgaaagg aataatagac tttctgcgaa   894480
acaaaaatat aatacaataa aactatgaat gatgaagcaa gtaaacaatt gagcgatagc   894540
cgtttcaaga tccttgtagg tgttcagcgc acgacttttg aagagatgtt agctgtgtta   894600
aaaacagctt atcaacgtaa acgcgcaaaa ggtggacgaa aaagcaaatt aagcctagac   894660
gatctcctta tggtaactat tcaatacatg cgagaataga gcacttatga acaaattgcg   894720
gctgattttg gcattcacga aagcaactta atccgtcgga gtcaatgggt tgaagcaact   894780
cttattcaaa atggttttac gatttcaaat tctgccttaa ttctgtaaaa acagtaaaat   894840
tcgaaggatt gtaaggtaag agtttttttc tttctgaaaa aatggtataa tagcaatcaa   894900
aactagaaaa taaaacggaa tttggaacag atttgtctgt atcctagtag agtggtgata   894960
ctatgaagat tagtaagagg cacttattaa attattccat cttgattccc tacttgcttt   895020
tatctatttt gggcttgatt gtggtctatt cgaccaccag tgctatttta attgaagaag   895080
gcaagagcgc cttgcagttg gttcgaaacc aaggaatctt ttggattgtt agtttgatac   895140
tgattgcctt aatttataaa ttgagactag attttttgag aaatgagcga ctaatcattt   895200
tagttatatt aatagaaatg cttttattgt tcttggctcg ttttattggt atttccgtaa   895260
acggggcata cggttggatt tcggttgcag gaataactat tcagccagct gagtacttaa   895320
aaatcattat tatttggtat ttagctcacc gattctccaa acagcaagaa gaaatagcta   895380
cttatgattt tcaagttttg actcaaaatc aatggcttcc ccgtgctttt aatgattggc   895440
gattcgttct cctagttctg attggaagtt tgggaatttt ccctgattta ggaaatgcga   895500
ctattttagt cttggtttcc ttgattatgt atacagttag tggaatcgct tatcgctggt   895560
tttcaaccat tctggcgctc gtatctgccg cttctgtctt tgtcttgacc actatcagcc   895620
taatcggtgt tgagaccttt tcaaaaattc cagtattcgg ctatgtagcc aagcgcttta   895680
gtgccttttt taatcctttt gccgatcgtg ctgatgcagg tcaccagtta gctaattctt   895740
attttgccat ggtcaatggc ggttggtttg gtctaggtct tggaaactcg attgaaaaac   895800
gaggttattt gccagaagct catacagact ttgtcttttc tatcgtgatt gaagaatttg   895860
gctttgttgg tgccagtctt attttagctc tcttgttttt catgattttg cggattatct   895920
tggtcggtat ccgagcggag aatcctttca atgccatggt tgcactcggt gtcggaggga   895980
tgatgttggt tcaggtattt gtcaatatcg gagggatttc gggcttgatt ccatctacag   896040
gagtgacttt ccccttctta tcccagggtg gaaatagtct tctagtctta tcagtggcag   896100
tagcctttgt cttaaatatt gatgccagtg aaaaacgcgc taaattgtac cgagaattgg   896160
aaaatcaacc aatgaacctt ctgttgaagt aggataaaga aaggatagtt tatgtctctt   896220
caaaaattag aaaattatag taataaaagt gttgtgcaag aagaagtctt gattctaaca   896280
gaattactgg aagatattac taaaaatatg cttgccccag agacctttga aaaaataata   896340
cagttgaaag aattatcaac gcaggaagat tatcaaggtc taaaccgtct agtgactagc   896400
ttatcaaatg atgaaatggt ctatatttca cgctatttct ctatcttgcc tcttttgatt   896460
aatatttcag aggatgtgga tttagcttat gaaatcaatc atcaaaataa tattgatcag   896520
gactatttag gtaaattatc tacaacgatt aaattggtag cagaaaagga aaatgccgtt   896580
gagatcctag aacacttgaa tgttgtccct gttttgacag cccatccaac acaagtgcaa   896640
cgcaaaagta tgttggattt aacaaatcat attcatagtc ttttgcgtaa ataccgtgat   896700
gttaagttgg ggttgatcaa taaagataaa tggtacaatg atttgcgtcg ttacatcgaa   896760
attatcatgc agacagacat gattcgtgag aaaaaattaa aagtgactaa cgaaatcacg   896820
aatgctatgg aatattataa cagctccttt ttgaaagctg tacctcattt gacgacggag   896880
tataagcgct tagcgcaagc gcatggtctg aatttaaaac aggctaaacc aatcaccatg   896940
ggtatgtgga taggtggtga ccgtgatgga aatccatttg ttacagcaaa gaccttgaag   897000
cagtctgcac tcactcagtg tgaagtcatc atgaactact atgataaaaa gatttaccaa   897060
ctttatcgtg aattttctct ttcaactagc attgtcaacg tcagcaagca agtcagagaa   897120
atggctcgtc aatccaagga taactcgatt taccgcgaaa aagagcttta ccgtcgtgcc   897180
ttgtttgata ttcaatcaaa aattcaggca actaaaacct atctgattga ggatgaagaa   897240
gttgggactc gttatgaaac cgccaatgat ttctacaagg atttgattgc cattcgagat   897300
tctctactag aaaataaggg cgagtccttg atttcaggtg attttgtgga attattgcag   897360
gcagtagaga tatttggttt ttacttagca tcaattgata tgcgacaaga ctctagcgtc   897420
tatgaagcct gtgtggcaga actcttgaaa tcagcaggaa ttcattctcg ttatagcgag   897480
ttgagcgaag aagaaaagtg tgaccttctc ttgaaagaat tagaagaaga tccccgaatt   897540
ctttctgcga ctcacgcaga aaaatcagaa ttattagcaa aagaattagc tatttttaag   897600
acggctcgtg ttttgaaaga taagttggga gatgatgtca tccgtcagac catcatttca   897660
catgcaacca gcctttctga tatgctagaa ttagctattc tgttaaaaga agtaggactg   897720
gtggatacgg aaagggcgcg tgttcagatt gttccccttt ttgaaacaat tgaagacttg   897780
gatcattcag aggaaacaat gagaaaatat ctttctctta gccttgccaa aaaatggatt   897840
gactcacgaa ataactacca agaaatcatg cttggctact ctgacagtaa taaagatggc   897900
ggttacttgt catcatgttg gaccctctac aaggctcaac aacaattgac tgctattgga   897960
gatgaatttg gcgttaaggt taccttcttc catggtcgtg gtggtactgt cggtcgtggt   898020
ggtgggccaa cctatgaagc cattacatct caaccgctca agtctatcaa ggatcgtatc   898080
cgcttgacgg agcagggtga agtaattggg aataaatacg gtaacaaaga cgccgcttac   898140
tataaccttg aaatgctagt atcggcagct attaaccgta tgattactca gaagaagagc   898200
gataccaata ccccaaatcg ttatgaaacc attatggatc aagtagtgga ccgtagttac   898260
gatatctacc gtgatttggt ctttggtaat gagcatttct atgattattt cttcgagtca   898320
agtccaatca aggctatttc aagttttaat attggttctc gtccagccgc tcgtaagact   898380
attactgaaa tcggtggttt gcgtgccatc ccttgggtat tctcatggtc acagagtcgt   898440
gttatgttcc ctggatggta cggggttggt tcaagcttca aggaatttat caataaaaat   898500
ccagagaata ttgctatctt acgagatatg taccaaaatt ggcctttctt ccaatcgctt   898560
ctttcaaatg ttgatatggt tttgtcaaaa tcaaatatga atattgcttt tgaatatgct   898620
aaactttgtg aagacgagca agttaaggcc atctatgaga ctattttaaa tgaatggcaa   898680
gttactaaga acgttatctt ggctattgaa ggacatgacg aactcttagc tgacaatcca   898740
tatctaaaag ctagtctgga ttaccgtatg ccttacttta atattctcaa ctatattcag   898800
ttggagttga ttaaacgcca acgtcgtgga gaattgtcca gtgatcaaga acgattgatt   898860
catatcacca tcaacggaat tgcgacagga ttgcgtaatt caggttgata attttcaaga   898920
gtgaatgcta aaagtgaata tcaaaaaaat tctaatagac tattgacaag tagtttaaaa   898980
atgatataat ttaaccattc agaaaagtaa tcatacaaac tttttagaga gtctgtggta   899040
gctgaaaaca gataagtggc aatgatgaaa attgggctga atgctattta gaatttgaaa   899100
ttataaaaat tcggtaagca caccttacag tgcatctcgt tattgcgaga ctgagcgata   899160
gggaaattcc ctataattga ggtggtaccg cgcatcgacg tcctcacaca agttttttgt   899220
gtgaggattt ttttgatgga ggttagtatg gaaagaaaac gatggcgtcg cttgtttaga   899280
taagtgaaat atgttaaagg aaataaaaag gagaaacaga atgaaaaata aacgtttaat   899340
tggaattatt gctgcattag cagtcttagt agcaggaagc ttgatttatt cttcaatgaa   899400
taaatcagaa gctcagaata ataaggatga gaagaaaata accaagattg gtgtgcttca   899460
atttgtgagc catccatccc ttgatttgat ttataaaggg atccaagatg gacttgcaga   899520
agaaggatat aaagatgatc aagttaaaat tgattttatg aactcagaag gtgaccaaag   899580
taaggttgcg acaatgagta aacaattggt tgcaaatggg aatgaccttg tggttggtat   899640
cgcaacacca gcagcccaag ggttggctag tgcaacaaaa gacctaccgg ttatcatggc   899700
cgctattaca gacccaattg gtgctaactt ggttaaagat ttgaaaaaac caggtggcaa   899760
cgttacaggg gtatctgacc acaatccagc tcaacaacaa gttgaactca tcaaggctct   899820
gacaccgaat gtgaaaacaa tcggagctct ttactcaagt agcgaagaca attcaaaaac   899880
acaggtcgaa gaatttaagg cttatgctga aaaagcaggt ctgacagtgg aaacatttgc   899940
agttccttca acaaatgaaa ttgcctcaac tgtcactgtt atgactagca aggtagatgc   900000
tatttgggtt ccaattgata acaccattgc atcaggattt ccaacggttg tctctagcaa   900060
tcaaagttct aagaaaccaa tttatcccag tgcgacagct atggtagaag taggtggttt   900120
ggcatcagtt gtaattgacc aacatgacct tggtgtggca acaggtaaaa tgattgtgca   900180
agtcttgaaa ggtgcaaaac cagccgatac cccagtcaat gtcttttcaa ctggtaagtc   900240
agtcatcaat aaaaaaatag cacaagaact aggtattact attcctgagt ctgttctcaa   900300
agaagcagga caagtcatcg aataaataag gtagggagga ggagactctt cccatttttt   900360
aaaaagatga atatagaaag gattaaataa aatatgattg tttccattat ttctcaagga   900420
tttgtctggg ctattctagg tctgggaatc tttatgacat ttaggatttt aaactttcca   900480
gatatgacga cagaaggttc cttccctctt gggggagctg ttgctgtcac tttgataacc   900540
aaaggcgtga acccattttt agcgacactt gttgctgtag gagcaggttg tttggctgga   900600
atggcagcag gccttcttta tacaaaaggg aagatcccaa ccttgctctc agggattttg   900660
gtgatgactt cttgtcactc aatcatgctc ttgattatgg gacgtgcgaa tttaggcctg   900720
cttggaacca agcaaattca ggatgttttg ccttttgatt cggatttgaa tcaactcttg   900780
acaggtctca tctttgtgag tattgttatt gctctcatgc tctttttctt ggacactaaa   900840
ctcggacaag cctatattgc tacaggggat aatcctgata tggctagaag tttcgggatt   900900
catactggac gcatggagct catgggcttg gtcttatcaa atggtgtgat tgcccttgca   900960
ggtgccctca ttgctcagca agaaggttat gccgatgtgt ctcgagggat cggggttatc   901020
gttgtggggc ttgcaagttt gattattgga gaagttattt tcaagagttt gagcttggca   901080
gagcgtttgg ttactatcgt tgtaggttct atcgcttatc aatttttagt gtgggcagtt   901140
atcgcacttg gctttaatac aagttacctt cgtttataca gtgccttgat tttagcagtc   901200
tgcctcatga ttccaacatt taagcaaaca atcttgaaag gagccaagtt aagcaaatga   901260
cagcaattgt agaattaaaa aatgcaacca aaatcgttaa aaatggcttt gatgaagaaa   901320
agattatttt aaatgatgtt tccttagaaa tttttgaacg ggactttatc acgattttgg   901380
gcggaaatgg tgctggaaaa tcaactctct ttaacactat agcagggacc ttatcactaa   901440
ctagtggaac tatccgtatt ttaggtgaag atctcactaa gttttcaccc gagaagcgtg   901500
ccaagtacct gtctcgtgtc ttccaagatc caaagatggg gacagctccc cgtatgacgg   901560
tcgctgaaaa tcttttaatc gccaagtttc gtggtgaaaa gcgtggattg ttaccacgac   901620
gcttgactag ctataaggat gaatttcagg caaccattga aaaagtagga aatggtcttg   901680
agaaacactt gaatacaccg attgagttct tatcaggtgg acaaagacag gctttgagtc   901740
tcttgatggc aaccttgaag cgacctgaat tactcctgtt agatgagcat actgctgccc   901800
tggatccaaa gactagtgtt gctttgatgg aattgacaga tgaatttgtt aagaaagatc   901860
agctaacagc ccttatgatt actcatcata tggaagatgc tctcaaatac ggcaatcgct   901920
tgattgtcat gaaagaagga cgaattatcc aagatttaaa ccaagaagaa aaagcaaaaa   901980
tgaaaatctc tgattattat caactctttg aataaagtag ggaaaatgag tgaaatggtt   902040
tacttttttt ctgaaataaa gtatactata taaagtaaac tatgataaca tggaggtatt   902100
gtgtatggtt gacaaacaag tcattgaaga aatcaaaaac aatgccaaca ttgtggaagt   902160
cataggagat gtgatttctt tacaaaaggc aggacggaac tatctagggc tctgtccttt   902220
tcatggtgaa aaaacaccat ctttcaatgt tgtagaggac aagcagtttt atcactgttt   902280
cggttgtggt cgctcaggtg atgtctttaa gttcatcgag gagtaccaag gggttccctt   902340
tatagaagca gtccaaatct taggtcagcg tgttggaatt gaggttgaaa aaccgcttta   902400
tagtgagcag aagtcagcct cacctcacca agctctttat gatatgcacg aagatgcagc   902460
caaattttac catgctattc tcatgacaac gactatgggc gaagaggcca gaaattacct   902520
ttatcagcgg gggttgacag atgaagtgct taaacatttt tggattggtt tagcacctcc   902580
agaacgaaac tatctctatc aacgtttgtc tgatcagtat cgtgaagagg atttactgga   902640
ttcaggcctg ttttatctct cggatgccaa tcaatttgta gacacctttc acaatcgcat   902700
tatgtttccc ctgacaaatg accaaggaaa ggtcattgcc ttctcaggtc gtatctggca   902760
aaaaacggat tcacaaactt ctaagtataa aaacagccga tcgactgcaa tttttaacaa   902820
aagttacgaa ttatatcata tggatagggc aaaaagatct tctggaaaag ctagtgagat   902880
ttacctgatg gaaggattca tggatgttat tgcagcctat cgggctggaa tcgaaaatgc   902940
tgtggcgtcg atgggaacag ccttgagtcg agagcatgtt gagcatctga aaaggttaac   903000
caagaaattg gttcttgttt acgatggaga taaggctggg caagccgcga cattgaaagc   903060
attggatgaa attggtgata tgcctgtgca aatcgtcagc atgcctgata acttggatcc   903120
tgatgagtat ctacaaaaaa atggtccaga agacttggcc tatctattaa cgaaaactcg   903180
tattagtccg attgagttct acattcatca gtacaaacct gaaaacagtg aaaatctgca   903240
ggctcagatt gagtttcttg aaaaaatagc tcccttgatt gttcaagaaa agtccatcgc   903300
tgctcaaaac agctatattc atattttagc tgacagtctg gcgtcctttg attataccca   903360
gattgagcag attgttaatg agagtcgtca ggtgcaaagg cagaatcgca tggaaggaat   903420
ttccagaccg acgccaatca ccatgcctgt caccaagcag ttatcggcta ttatgagggc   903480
agaagcccat ctactctatc ggatgatgga atcccctctt gttttgaacg attaccgttt   903540
gcgagaagac tttgcatttg ctacacctga atttcaggtc ttatatgact tgcttggcca   903600
gtatggaaat cttcctccag aagttttagc agagcagaca gaggaagttg aaagagcttg   903660
gtaccaagtt ttagctcagg atttgcctgc tgagatatcg ccgcaggaac ttagtgaagt   903720
agagatgact cgaaacaagg ctctcttgaa tcaggacaat atgagaatca aaaagaaggt   903780
gcaggaagct agccatgtag gagatacaga tacagcccta gaagaattgg aacgtttaat   903840
ttcccaaaag agaagaatgg agtaataatg gcaacaaaac aaaaagaagt aacaacattt   903900
gacgtacagg tagcagaatt tatccgtaat cataagcaaa aagggacagc aacagatgat   903960
gaaatcaatg caagtctggt tattcctttt accttggacg ctgatgggat tgaagatctc   904020
ttgcaacgga ttcaggatgc aggcatttct atcacagata acgaaggaaa tccaagtgcg   904080
cgtgttctca gcaatgaaga agaaccagaa ctcagcgatg aggacttgat tgggtcaact   904140
tctgctaagg tcaatgaccc tgtccgtatg tacttgaaag aaataggggt cgttcctctc   904200
ttgaccaatg aagaggagaa agagttggca ctggctgttg aagctggtga tatcgaagcc   904260
aaacaacgtc ttgcggaagc caatcttcgt ttggttgttt ccattgccaa acgctatgtc   904320
ggtcgtggta tgcagttcct tgacttgatt caagaaggaa atatgggctt gatgaaggcg   904380
gttgacaagt ttgactattc taaagggttc aagttttcaa cttatgcaac ttggtggatt   904440
cgtcaggcta tcactcgtgc tattgcggac caagctcgta ccatccgtat cccagttcac   904500
atggttgaaa ctatcaataa attggttcgt gaacagcgga atctccttca agaattgggg   904560
caagatccga caccagaaca gattgctgaa cgaatggata tgacacctga taaggttcgt   904620
gaaatcttga agattgccca agaaccagta tctcttgaaa ctcctatcgg tgaagaggac   904680
gatagccacc ttggagactt tatcgaagat gaagtgattg aaaatccagt ggattatacg   904740
actcgtatcg tcttgcgtga gcaattggat gaaatcttag atactcttac agaccgtgaa   904800
gaaaatgttc tgcgtctacg ttttggacta gatgatggaa aaatgcgcac acttgaagat   904860
gtggggaaag tctttaacgt aactcgtgag cgtatccgtc agattgaagc aaaggctttg   904920
agaaaactac gccaaccaag tcgtagcaaa ccgcttcgtg attttattga agactaagag   904980
tgaggaaaat atggcttata cagaagagca aattgaaaac atcaaaacac ggattttaac   905040
agccttggaa gaagtcatcg accctgagtt gggaatcgat attgtcaatc ttggtttgat   905100
ctatgagatt cgttttgacg gtgacacagg gcaaacagag attgacatga ctttgacaac   905160
tatgggttgt cccttagcag accttttgac agaccagatt tatgatgcta tgatagaggt   905220
tccagaagta acggatactg aggttaaatt agtctggtat ccagcctgga cagttgaaaa   905280
aatgagtcgc tatgcccgca ttgccctagg cattaagtaa acatataaaa gcatgtgaga   905340
gactgttgga aaagcgagga aatttcccct cttttcctct agtctctcct ttcttttgct   905400
gattttattc aaagaaaatg atataatagt agttatggag aaaaagaaat tacgcatcaa   905460
tatgttgagt tcaagtgaga aagtagcagg acagggagtt tcaggtgctt accgtgaatt   905520
agttcgtctt cttcaccgtg ctgccaagga ccaattgatt gttacagaaa atcttccaat   905580
cgaggcagat gtgactcact ttcatacgat tgattttccc tattatttat caaccttcca   905640
aaagaaacgc tcagggagaa agattggcta tgtgcatttc ttgccagcta cacttgaggg   905700
aagtttgaaa attccatttt tcttaaaggg aattgtgaaa cgctatgtat tttcttttta   905760
caaccggatg gagcacttgg ttgtggtcaa tcctatgttt attgaggatt tggtagcagc   905820
tggtattcca cgtgaaaaag tgacctatat tcctaacttt gtcaacaagg aaaaatggca   905880
tcctctacca caagaagagg tagtcagact gcgcacagat cttggtctta gtgacaatca   905940
gtttatcgta gtaggtgctg ggcaagttca gaaacgtaaa gggattgatg actttatccg   906000
tctggctgag gaattgcctc agattacctt tatctgggct ggtggcttct cttttggtgg   906060
tatgacagat ggttatgaac actataagaa aattatggaa aatcccccta aaaatttgat   906120
ttttccaggc attgtatcgc cagagcggat gcgcgaattg tatgctctag cggatctttt   906180
cttgttgcct agttacaatg agctctttcc tatgactatt ttagaagctg cgagttgtga   906240
ggctcctatt atgttgcgtg atttagatct ctataaggtg attttggagg gaaattatcg   906300
ggcgacagcg ggtagagaag agatgaaaga ggctattttg gaatatcaag caaatcctgc   906360
tgtcttaaaa gatctcaaag aaaaggctaa gaatatttcc agagagtatt ctgaagagca   906420
tctgttacaa atctggttgg acttttatga gaaacaagcc gctttaggga gaaagtaaaa   906480
agtgaggtaa tctatgcgaa ttggtttatt tacagatacc tattttcctc aggtttctgg   906540
tgttgcgacc agtattcgaa ccttgaaaac agaacttgaa aagcagggac atgctgtttt   906600
tatctttacg acgacagata aggatgtcaa tcgctacgaa gattggcaaa ttatccgcat   906660
tccaagtgtt cctttctttg cttttaagga tcgtcgcttt gcctaccgag gttttagcaa   906720
ggcacttgaa attgctaaac agtatcagct agatattatc catactcaga cagaattttc   906780
tcttggcctg ttggggattt ggattgcgcg tgaattgaaa attccagtca tccataccta   906840
tcacacccag tatgaagact atgtccatta tattgctaag gggatgttga tccggccgag   906900
tatggtcaag tatctggtta gaggtttcct gcatgatgtg gatggggtta tttgccctag   906960
tgagattgtc cgtgacttgc tatctgatta taaggtcaag gttgaaaaac gggtcattcc   907020
tactgggatt gaattagcca agtttgagcg tccggaaatc aagcaggaaa atttgaaaga   907080
actgcgtagt aaactaggga ttcaagatgg tgaaaagacg ttgcttagtc tttcgagaat   907140
ctcctatgaa aaaaatattc aagcagtttt agcagccttt gctgatgttc tgaaagagga   907200
agacaaggtt aaactggtag tagctgggga tggcccttat ctgaatgacc tcaaagagca   907260
agcccagaac ctagagattc aagactcagt catctttaca gggatgattg ctcctagtga   907320
gacggctctt tactataaag cggcggattt cttcatttcg gcatcgacaa gcgaaacgca   907380
aggtttgacc tacttggaaa gcttagccag tggaacacct gtcattgctc acggaaatcc   907440
ttatttgaac aacctcatca gtgataaaat gtttggaacc ttgtactatg gagaacatga   907500
tttggctggt gctattttgg aagccctgat tgcaacacca gacatgaacg agcatacctt   907560
atcagagaaa ttgtatgaga tttcagctga gaactttggg aaacgagtgc atgagtttta   907620
tctggatgcc attatttcaa ataacttcca gaaagatttg gctaaagatg atacggtcag   907680
tcagcgtatc tttaagacag ttttgtatct tcagcaacag gtggttgctg tacctgtaaa   907740
aggatctaga cgcatgttga aggcttcaaa aacacagttg atcagtatga gagactattg   907800
gaaagaccat gaagaataga aagaggaaca gctatgaaaa aaacaattaa tgagaagcgg   907860
tcgtgataaa aagattgcgg gtgtttgtgc tggggtggcc cattatctgg atatggatcc   907920
gactatcgtt caagtcattt ggggtgttct tacttgctgt tacggagctg gaattgtagc   907980
ttacattatt ttatggatta tcgcaccagt agcaactgac tattgaaaac tagctcaatt   908040
catgctaaga taatagaaaa tagaatgtaa cgaaggagag aaaaatggca tttggagata   908100
atggaaatcg taaaaaaact atgtttgaga aaataacctt gtttatcgtg attatcatgc   908160
tagtagcaag tttattggga atttttgcaa ctgcaattgg tgccctcagt aatctataaa   908220
atagattcaa gaaaatttag tgactgggat ttcccagccc ttttttaaag tgagaagaaa   908280
taatgagtat gtttttagat acagctaaga ttaaggtcaa ggctggtaat ggtggcgatg   908340
gtatggttgc ctttcgtcgt gaaaaatatg tccctaatgg aggcccttgg ggtggtgatg   908400
gtggtcgtgg aggcaatgtg gtcttcgttg tagacgaagg actacgtacc ttgatggatt   908460
tccgctacaa tcgtcatttc aaggctgatt ctggtgaaaa agggatgacc aaagggatgc   908520
atggtcgtgg tgctgaggac cttagagttc gagtaccaca aggtacgact gttcgtgatg   908580
cggagactgg caaggtttta acagatttga ttgaacatgg gcaagaattt atcgttgccc   908640
acggtggtcg tggtggacgt ggaaatattc gtttcgcgac accaaaaaat cctgcaccgg   908700
aaatctctga aaatggagaa ccaggtcagg aacgtgagtt acaattggaa ctaaaaatct   908760
tggcagatgt cggtttagta ggattcccat ctgtagggaa gtcaacactt ttaagtgtta   908820
ttacctcagc taagcctaaa attggtgcct accactttac cactattgta ccaaatttag   908880
gtatggttcg cacccaatca ggtgaatcct ttgcagtagc cgacttgcca ggtttgattg   908940
aaggggctag tcaaggtgtt ggtttgggaa ctcagttcct ccgtcacatc gagcgtacac   909000
gtgttatcct tcacatcatt gatatgtcag ctagcgaggg ccgtgatcca tatgaggact   909060
acctagctat caataaagag ctggagtctt acaatcttcg cctcatggag cgtccacaga   909120
ttattgtagc taataagatg gacatgcctg agagtcagga aaatcttgaa gactttaaga   909180
aaaaattggc tgaaaattat gatgaatttg aagagttacc agctatcttc ccaatttctg   909240
gattgaccaa gcaaggtctg gcaacacttt tagatgctac agctgaattg ttagacaaga   909300
caccagaatt tttgctctac gacgagtccg atatggaaga agaagcttac tatggatttg   909360
acgaagaaga aaaagccttt gaaattagtc gtgatgacga tgcgacatgg gtactttctg   909420
gtgaaaaact catgaaactc tttaatatga ccaactttga tcgtgatgaa tctgtcatga   909480
aatttgcccg tcagcttcgt ggtatggggg ttgatgaagc ccttcgtgcg cgtggagcta   909540
aagatgggga tttggtccgc attggtaaat ttgagtttga atttgtagac taggagactg   909600
gtatgggaga taaaccgata tctttccgag atgcggatgg taattttgtt tccgccgcag   909660
acgtttggaa tgaaaagaaa ttggaagaac tatttaatcg tctcaatcca aatcgtgcct   909720
tgagattggc acgaactaaa aaggaaaatc catctcagta aagaagctaa aaaatcccgt   909780
gcctcatcag acacgggatt ttgtggtacg acaggcatgt atagcaaact gaatctggaa   909840
tagcacagca tatcttctaa aatatagtaa aatgaaatga gaacaggaca aatcgatcag   909900
gacagtaaaa tcgatttcta acaatgtttt ataagcagag atgtactatt ctagtttcaa   909960
tcaactatat tgttataaat tgatttgaat ttcaaaatta aattgtttga ttcttatttc   910020
aatttgttat agtatatctg atgtcaaagt tctcggcgag tcaaatagcg attcccaagc   910080
ctgactatcg tgaggtagcg gattaaaatg gtctggggat agaccgtttt aagtctgacg   910140
ctggaaataa gaattgtcag aagaagggat agcgaaatcg tggctctacg aacaggaacg   910200
tgataataag gcgtatatag cggataagag ggcatcaaac tctaaagtcc aaaaaggtag   910260
tcgtaaccta tatgcgtaaa tcacgagagt aattgaattc gtactaagat tttctatttt   910320
cactgtaacc ttttaacgcc cttatatctt gtatacacga ggaaagatgt acgacttatc   910380
ccgtgaggtc tatcactata aagagaaaac gacagataga agtgatcctg agtcacggtt   910440
atctgtctga taggacggta tgtataaaac gcttctgtga actgagagaa gggggagaag   910500
ttcttgctaa aatttagttg aacagccgta ttccgatact tagataagag atctagtctt   910560
agctcctact cagttttagg ggataaaaaa ggggcaatag cgattcgaga aagattatac   910620
tcttcgaaaa tctcttcaaa tcacgtcaat atcgccttgt cgtatgtgta ggatactgac   910680
tacgtcagtt ccatctacaa cctcaaaaca gtgttttgag caacctgcgg ctagtttcct   910740
agtttgatct ttgattttca ttgagtatta gtaattcagt tactaactcg tcaactctga   910800
tttatccaat aaaattgaaa aggatggaaa aaaggataaa tttatgatat actttatttt   910860
gaagacctta ttagaaatct tgaaagagta ttgaaaactt agaatgagaa aaattgttat   910920
caatggtgga ttaccactgc aaggtgaaat cactattagt ggtgctaaaa atagtgtcgt   910980
tgccttaatt ccagctatta tcttggctga tgatgtggtg actttggatt gcgttccaga   911040
tatttcggat gtagccagtc ttgtcgaaat catggaattg atgggagcta ctgttaagcg   911100
ttatgacgat gtattggaga ttgacccaag aggtgttcaa aatattccaa tgccttatgg   911160
taaaattaac agtcttcgtg catcttacta tttttatggg agcctcttag gccgttttgg   911220
tgaagcgaca gttggtctac cgggaggatg tgatcttggt cctcgtccga ttgacttaca   911280
ccttaaggcg tttgaagcta tgggtgccac tgctagctac gagggagata acatgaagtt   911340
atctgctaaa gatacaggac ttcatggtgc aagtatttac atggatacgg ttagtgtggg   911400
agcaacgatt aatacgatga ttgctgcggt taaagcaaat ggtcgtacta ttattgaaaa   911460
tgcagcccgt gaacctgaga ttattgatgt agctactctc ttgaataata tgggtgccca   911520
tatccgtggg gcaggaacta atatcatcat tattgatggt gttgaaagat tacatgggac   911580
acgtcatcag gtgattccag accgcattga agctggaaca tatatatctt tagctgctgc   911640
agttggtaaa ggaattcgta taaataatgt tctttacgaa cacctggaag ggtttattgc   911700
taagttggaa gaaatgggag tgagaatgac tgtatctgaa gacagcattt ttgtcgagga   911760
acagtctaat ttgaaagcaa tcaatattaa gacagctcct tacccaggct ttgcaactga   911820
tttgcaacaa ccgcttaccc ctcttttact aagagcgaat ggtcgtggta caattgtcga   911880
tacgatttac gaaaaacgtg taaatcatgt ttttgaacta gcaaagatgg atgcggatat   911940
ttcgacaaca aatggtcata ttttgtacac gggtggacgt gatttacgtg gggccagtgt   912000
taaagcgacc gacttaagag ctggggctgc actagtcatt gctgggctta tggctgaagg   912060
taaaactgaa attaccaata tcgagtttat cttacgtggt tattctgata ttatcgaaaa   912120
attacgtaat ttaggagcgg atattagact tgttgaggat taaaccgtag aggtgtttat   912180
gaatatttgg accaaattag caatgttttc tttttttgaa acggatcgct tgtatttgcg   912240
tcctttcttt tttagtgata gtcaggactt ccgcgagata gcttcaaatc cagaaaatct   912300
tcaatttatt ttcccaacgc aggcaagtct ggaagaaagt caatatgcac tggccaatta   912360
ctttatgaag tcccctttgg gagtgtgggc aatttgtgac cagaaaaatc aacaaatgat   912420
tggttctatt aaatttgaga agttagatga aatcaaaaaa gaagctgagc ttggctattt   912480
tttgagaaaa gatgcttggt cgcaaggatt tatgacagag gttgttagaa aaatttgtca   912540
gctttctttt gaggaatttg gcttaaaaca attatttatc attacccacc ttgaaaataa   912600
agctagccaa agagttgctc ttaagtctgg atttagtttg ttccgtcagt ttaagggaag   912660
tgatcgttac acaagaaaaa tgcgggatta tcttgaattt cggtatgtaa aaggagagtt   912720
caatgagtaa gcatcaggaa attctaagct atttggagga attaccagta ggtaaaaggg   912780
tcagtgttcg tagcatttcg aatcatctag gagttagtga tggaacagcc tatcgggcta   912840
ttaaagaagc tgaaaaccgt ggaattgtgg agacccgtcc tagaagtgga acaattcgtg   912900
ttaaatccca gaaagttgct atagagagat taacgtttgc tgaaattgca gaagtgactt   912960
cttctgaggt tctggctggg caagaaggtt tagagagaga atttagtaag ttttcaattg   913020
gtgccatgac tgaacaaaat atcttgtctt accttcatga tggggggctc ttgattgtcg   913080
gagaccgaac ccgtattcag ttgctagcct tggaaaatga aaatgcagtt ctggttacag   913140
ggggatttca ggttcatgat gatgtgctta aactggccaa tcaaaaaggg attcctgttc   913200
taagaagtaa gcatgatacc tttaccgtcg cgaccatgat caataaagcc ttgtcaaatg   913260
tccaaatcaa gactgatatt ctgacagttg agaaacttta tcgccctagt catgagtatg   913320
gttttctgag agagacagat acagttaaag attatttgga cttggttcgt aagaatcgta   913380
gcagccgttt ccctgttatc aatcaacatc aggtcgttgt tggtgttgta accatgagag   913440
acgctggtga taaatcacca agcacgacaa ttgataaggt tatgtctcgt agtctatttt   913500
tggttggatt atcgacaaat attgccaatg tgagtcaacg gatgatcgca gaagactttg   913560
aaatggtacc agttgttcga agcaatcaaa ctttgcttgg cgttgtgacg cgacgagatg   913620
tcatggagaa gatgagccgt tcccaagttt cggctctacc aactttttct gagcagattg   913680
gacaaaagct ctcttatcac catgatgaag tagtcattac agtggaaccc tttatgctag   913740
aaaaaaatgg agttttggct aatggtgtat tggcagaaat tctgacccac atgacccaag   913800
atttagttgt taatagtggt cgcaatctca ttatcgagca gatgctgatc tactttttgc   913860
aggctgttca gatagatgat atattgcgca ttcaggcacg gattattcat catacgagac   913920
ggtcagctat aattgattac gatatttatc atggtcacca gattgtttca aaagcaaatg   913980
tgactgttaa aattaattag aaactaggag aaaagatgat aacattaaaa tcagctcgtg   914040
aaatcgaagc tatggacaag gctggtgatt ttctagcaag tattcatata ggcttacgtg   914100
atttgattaa gccaggcgta gatatgtggg aagttgaaga atatgtccgc cgtcgttgta   914160
aagaagaaaa tttccttcca cttcagattg gggttgacgg tgccatgatg gactatcctt   914220
atgctacctg ttgctctctt aacgatgaag tggctcacgc tttccctcgt cattatatct   914280
tgaaagatgg tgatttgctc aaagttgata tggttttggg aggtcccatt gctaaatctg   914340
acctaaatgt ctcaaaatta aacttcaaca atgttgaaca aatgaaaaaa tacactcaga   914400
gctattctgg tggtttagca gactcatgtt gggcttatgc tgttggtaca ccgtccgaag   914460
aagtcaaaaa cttgatggat gtaaccaaag aagctatgta caagggtatt gagcaagctg   914520
ttgttggaaa tcgtatcggt gatatcggtg cggctattca agaatacgct gaaagtcgtg   914580
gttacggtgt agtgcgtgat ttggttggtc atggtgttgg cccaactatg cacgaagaac   914640
caatggttcc taactatggt attgcaggtc gtggactccg tcttcgtgaa ggaatggtct   914700
taaccattga accaatgatc aatacaggcg attgggaaat tgatacagat atgaaaactg   914760
gttgggcgca taagaccatt gacggtggat tgtcatgtca gtatgaacac caatttgtca   914820
ttacgaaaga tggacctgtt atcttgacta gccaaggtga agaaggaact tattaataaa   914880
aagtgaaaag actactggaa gtttattttg ataaaaaatc cagtagatct tttcataata   914940
aaacgcattg tatcaagtgt taggggctga tatcatgcgt ttttctgctt ttaagatttt   915000
ttccaactct gtttgtaagc gcatcataac aaagggtcta ggattcaggg ctctcctcct   915060
atatactatt agtaaagtaa aactaaggga ggatatttta gtgtcgcagt ctattgttcc   915120
tgtagagatt ccacaatatt gtcgttttga ttctaaaaag agaaatggaa ttctgtttaa   915180
tgttcgtatt gccaatctta aatttacttt tttatattat acttcctgcg aaacaaaata   915240
tggtatagta gttctatgaa tgatgaagca agtaaacaac taactgatgc acgatttaag   915300
cgtcttgttg gtgttcagcg taccactttt gaagagatgt tagctgtatt aaaaacagct   915360
tatcaactta aacacgcaaa aggtggacga aaacctaaat taagcctaga agaccttctt   915420
atgcccactc ttcaatagtg cgagaatatc gaacttatga agaaattgcg gctgattttg   915480
gtattcacga aagcaacttt atccgtcgga gccaatgggt tgaaataact cttgttcaaa   915540
gtggttttac ggtttcaaga actcctctca gttctgagga cacggtaatg attgatgcga   915600
cggaagtaaa aatcaatcgc cctaaaaaaa caattagcga atgattctgg taaaaagaaa   915660
tttcacgcta tgaaggctca agcgattgtc acaagtcaag ggagaattgt ttctttggat   915720
atcgctgtga actatagtca tgatatgaag ttgttcaaaa tgagtcgtag aaatatcgaa   915780
caagctggta aaatcttggc tgacagtggt tatcaagggc tcatgaagat atatcctcaa   915840
gcacaaactc cacgtaaatc cagcaaactc aagccgctaa cagctgaaga taaagcctat   915900
aaccatgcgc tatctaagga aagaagcaag gttgagaaca tctttgccaa agtaaaaacg   915960
tttaaaatat tttcaacaac ctatcgaaat catcgtaaac gcttcggatt acgaatgaat   916020
ttgagtgctg gtattatcaa tcatgaacta ggattctagt tttgcaggaa gtctattgag   916080
gtattgagct agtttatgaa aaaattgggt gaaaagtcga gtgttttaga aacccacagt   916140
gtagtattct agtttcaatc cactatattt tgctactccc cgtaaagttt ctattttccc   916200
tgatttctga tataatagaa atattgactt caagagtaag gaagagaaga tgaacgcatt   916260
attaaatgga atgaatgacc gtcaggctga ggcggtgcaa acgacagaag gtcccttgct   916320
aatcatggca ggggctggtt ctggaaagac tcgtgttttg acccaccgta tcgcttattt   916380
gattgatgaa aagctggtca atccttggaa tatcttggcc attaccttta ccaacaaggc   916440
tgcgcgtgag atgaaagagc gtgcttatag cctcaatcca gcgactcagg actgtctgat   916500
tgcgaccttc cactccatgt gtgtgcgtat tttgcgtcgc gatgcggacc atattggcta   916560
caatcgtaat tttacaattg tggatcctgg tgaacagcga acgctcatga aacgtattct   916620
caaacagttg aacttggacc ctaaaaaatg gaatgaacga actattttgg ggaccatttc   916680
caatgctaag aatgatttga ttgatgatgt tgcttatgct gcccaagctg gcgatatgta   916740
tacgcaaatt gtggcccagt gttatacagc ctatcaaaaa gaacttcgtc agtctgaatc   916800
cgttgacttt gatgatttga ttatgctgac cttgcgtctc tttgatcaaa atcctgatgt   916860
tttgacctac taccagcaaa aattccaata catccacgtt gatgagtacc aagataccaa   916920
ccacgctcag taccaattgg tcaaactctt ggcttcccgt tttaaaaata tctgtgtggt   916980
tggggatgcg gaccagtcta tctacggttg gcgtggtgct gatatgcaga atatcttgga   917040
ctttgaaaag gattacccca aagccaaggt tgttttgttg gaggaaaatt accgctcaac   917100
caaaaccatt ctccaagcgg ccaacgaggt tattaaaaat aataaaaatc gccgtcctaa   917160
aaatctctgg actcaaaacg ctgatgggga gcaaatcgtt tactatcgtg ccgatgatga   917220
gctggatgag gctgtatttg tagccagaac catcgatgaa cttagtcgca gtcaaaactt   917280
ccttcataag gattttgcag ttctctatcg gactaatgcc cagtcccgta caattgagga   917340
agccctgctc aagtctaaca ttccttatac catggttggc ggaaccaaat tctacagccg   917400
taaggaaatt cgcgatatta ttgcttatct caaccttatt gctaatttga gtgacaatat   917460
tagttttgag cgtattatca acgagcctaa acgtggaatt ggtctaggta cagttgagaa   917520
aatccgtgat tttgcaaatt tgcaaaatat gtctatgctg gatgcttctg ctaatattat   917580
gttgtctggt atcaagggta aggcagccca atctatctgg gattttgcca atatgatgct   917640
tgatttgcgg gagcagctag accacttaag cattacagag ttggttgagt ccgtcctaga   917700
aaaaacaggt tatgtcgata ttcttaactc ccaagcgact ctagaaagca aggcacgggt   917760
tgaaaatatc gaagagtttc tttctgttac gaagaacttt gatgacacca cggatgtgac   917820
agaagaggaa actggtctgg acaaactgag tcgtttctta aatgacttgg ctttgattgc   917880
cgacacagat tcaggtagtc aggagacatc agaagtgacc ttgatgaccc tgcatgctgc   917940
caaaggtctc gaatttccag ttgtcttttt gattgggatg gaagaaaatg tctttccact   918000
tagtcgtgcg actgaagatt cagatgaatt agaagaagag cgccgtctag cctatgtagg   918060
tatcacgcgt gcagagaaaa ttctctatct gaccaatgcc aactcacgct tgctttttgg   918120
tcgtaccaat tataaccgtc cgactcgttt tattaacgaa atcagttcag acttgcttga   918180
gtatcaaggt ctggctcgtc ctgcaaatac aagctttaag gcatcatata gcagtggtag   918240
tatttccttt ggtcaaggta tgagtttggc tcaggctctt caagaccgta aacgcggtgc   918300
tgccccaaaa tcaatccagt caagcggtct tccatttggt caatttacag ctggcgcaaa   918360
accagcatct agcgaggcaa attggtccat tggtgatatt gctctccaca agaaatgggg   918420
agagggaacc gttctggaag tttcaggtag cggtgctagg caggaattga aaatcaattt   918480
cccagaagta ggtttgaaaa aacttttagc cagtgtggct ccaattgaga aaaaaatcta   918540
attttccatc cttctcacga ataataaagt gaggaggatt tttatgtaca gtatttcatt   918600
ccaagaagat tcactattac caagagaaag gctggccaag gaaggagttg aagcgcttag   918660
taaccaagag ttgctagcta ttttactcag gacaggaaca cgtcaagcta gcgtttttga   918720
aattgcccaa aaagtcttga acaatctttc aagcctaacg gatttgaaaa aaatgaccct   918780
gcaggaattg cagagtttgt ctggtattgg gcgtgttaag gccatagaat tacaagctat   918840
gattgaactg gggcatcgta ttcacaaaca cgagactctt gaaatggaaa gtattctcag   918900
cagtcaaaag ttggccaaga agatgcagca ggaattaggg gataaaaaac aagagcacct   918960
ggtggcactc tatctcaata ctcaaaatca aatcatccat cagcagacca tttttatcgg   919020
gtctgtaact cgtagtatcg ctgaaccgcg agagattctt cactatgcaa tcaagcatat   919080
ggcgacttct cttatcttgg tccacaatca tccttcagga gcggtagcgc ctagccaaaa   919140
tgatgatcat gtcactaaac ttgttaaaga agcctgcgaa ttgatgggga ttgttctctt   919200
ggaccatttg attgtctctc attctaatta ctttagttat cgtgaaaaga cagatttaat   919260
ctaaagttca ttaacgacat agtcaaagag ttttttatct ttgggacgat tttcaaaaag   919320
aagttctgga tgccattgga caccgagaaa ggcgacatca tccgtactca tgacagcctc   919380
aatgatacca tctttaggat catgagccac aacttttaaa tttggtgcta agtccttgat   919440
gctctggtgg tggaaggagt tgatatgaga gatttctcca tagatttctt ggagaacggt   919500
atctggttct gttaccaagc gttgagttgt gtactcaaca gaagaatcct gccaatggtc   919560
ttcgatatct tggtacaaag ttccacccat ggcaacgtta aagagttggg taccacggca   919620
gacagagaaa atgggctttt tctgtttaat agcttccttg atgagggcca gttcgaagat   919680
atctctttga aggtgatagt catcactatc aatggttttg ggttcgccat aaaattttgg   919740
atcgacattt tgcccacctg tcaagatgag cttgtcaatc aaactgatat agtggcaggc   919800
catttcttga tcaccaatcg gtaggatgat gggaatccct ccagcatctt taacgccttc   919860
aacaaagcct tttgctgcgt agctcatcat gatgtcatca tctggatgag ttttttcgtt   919920
tcctgtaatc ccaataactg gttttttcat aaaatgattt tcgctttcta atcctctttt   919980
cgcatgaagt agaggagggt ttggagttca cttgtcaaat cgacatactg aacgaccacg   920040
tcttttggta aatgcagatg gactggtgaa aaactgagaa ttcctttcac accagcatca   920100
accaagagat tagcaacctc ttgtgacttg acgctgggaa cagttaggat agcagtcttc   920160
acatcagcat ccttgatttt atccttgatc tgagaaatcc cgtaaatggg aatcccgtca   920220
ggagtttggg taccgacttc aggatggtcg tctaggtcaa aggccatgat aatcttcatc   920280
ttgttacgtt cgtggaagcg gtagtggaga agggcatggc ccatatttcc aataccaacc   920340
agcatgacat tggtaataga gttgtcattg agcaaatcgg caaaaaatgt cattagtttt   920400
ttgacatcat agccaaaacc acgacgacca agttcaccaa aataggaaaa atcacgacgt   920460
acggtcgctg aatcaatacc gatagcctct gcaatttgct tagagttggc acgttcaatc   920520
ttttctgcat gaaatctctt aaaaattcga tagtagagag agagtctttt tgctgtagct   920580
tttggaatag caaactgttt atctttcaca aaatcacaac ctttctattc ttctatttta   920640
tagaaacatt gtgaaaaaat caacaaaaat aagaaaaaac taagaaaaat cttagttttg   920700
atgtaaaaaa tctgcatgag atagaaaacg gtagaggtct ccgaccagcc cctgataaac   920760
ttttttgccc ctaaaagtca gagaagtcac ataaagtgta tctggtaagg ttacacatcc   920820
tgacaaagtc aacatgagag cctcatgatc ctcatacttg agagtacgct ctacatgata   920880
gcagtcctta taggtcagtt caaacatttt ggctctatct ttccgatttt gtaaagacac   920940
cacgttctac caagctatcc atgaggaagt agaatttttc ctgatgaata tggtggtctt   921000
ctgatttgaa aatatcaact agacgaaggc caaacttgtc agtgatattg attttagccc   921060
ctgtaagttc cttgttaatg atgattttga gttggaagcc ttcaccgctg tttggcactt   921120
tttccaaaag gcgagtcagt tcatagttac caaccttagt ttcaaaaaag gtgttatctt   921180
tgagggtgaa ttttttaaca gaagggctaa gagtgtaatc gtaacgacaa ttttttaact   921240
gaatgatttt ttcaaatgcc atatggctaa cctccgataa tttcttttaa ggtttttgcg   921300
agggtttgta ggtcttcaac ggtattttgt ggcgacaaac tgatgcgaag ggattccttc   921360
aagcgttctg aatttgcgcc atacatggct tcaagaacat ggctggattg gacaacgcct   921420
gcagtacagg ctgagccagt agagattgaa attccagcta aatctagccg aaggagtaag   921480
aggtcatttt tctgaccagg aaatccaata ttgagaacat aagggagatg atgttttcct   921540
ctattcaggt aatactgaat gccctccagc tctgccagaa aggcagtttc tagattttgt   921600
acatgttgaa aatgttcttc ttgtttttct aggtcttctt ttagggctgc aaccatgcct   921660
acaatggcag gcagattttc agttcctgca cgttttttct gttcctggtc tccgccatgt   921720
agataggaat caaagtccat gctagatgcg tagagaaaac cgattccctt aggaccatgg   921780
aatttgtggg cagaagcagt gagaaaatca atgcccaatt cttctgaatg aattgggatt   921840
ttaccaatag cctgaactgc atcaacatga taggcagcag ggtgttgctt gagtatttgg   921900
ccaatttcag cgatgggcag taggtttcct gtctcattat tgacaaacat ggtagaaacc   921960
aaaatcgtat cgtcacgtaa agccttttga atttgctggg ctgtgatttc ttgattttct   922020
ggctggataa tggttgcttc aaacccaaag tgttgaacca agtaatcaat tgtttcaagg   922080
acagcatggt gctcgatggc agttgtgatg atatgttttc cttgttcttg gtgacgaaga   922140
cagtagccaa tgatggtagt attattgcct tcagtcccac cagaagtgaa aaagatatgt   922200
tgaggttttg tccttagtaa ctgggctagt tcctgacggg cttctcgcaa gagtttgcca   922260
gcttgacgac catgaccatg aatactagaa ggatttccgt gggtttcttg cataaccttg   922320
gtcatagctg aaatagcaac tgctgacata ggagtcgttg cagcattgtc caaataaatc   922380
aaagaatcac cttatttctt tttattgtag gcaaagagtg ggctgactgg ttttctttcg   922440
tgaatacgga cgatagcatc accaattaac tcactagcag tgatgtagca tacattttta   922500
ggagtttttt cttttgttgc tactgaatca gtcacaagaa tttctttaat attagtattg   922560
tcaagaagct cagcagctcc ctcgacgaag agaccgtggc tagaaacagc ataaatttct   922620
gtagctcctt cacgttcaac gattttagaa gcttcagaga aggtacgtcc tgtatttaaa   922680
atatcatcaa tcaagatagc tttcttacct tcaacatcac caataatata accttcgtta   922740
cgagttgcat cgtcttgagg gtagtcgata atggcgatag gagcatcaag atattcagcc   922800
aggctacgcg cacgtttgac acctgaattt ttagggctaa cgacaacaac atctgaacca   922860
agcaatcctt tatcgcagta atgttttgcg aataggggaa cagtgaaaag attatccact   922920
ggaatatcaa agaaaccttg aacctgaacg gcatgcaaat caagagtcag gatacgatca   922980
actccagcct taaccagcat attggcaact agttttgctg taagtggctc acgaggacaa   923040
gcaatgcggt cttgacgtgc atagccaaaa tatggaagga caacgttgat actgtgggca   923100
cttgcacgca cacaagcatc gaccatgatt aacaattcca ttaggtggtt gttgacaggg   923160
aaacttgttg attggatgat gtaaacatca taaccacgga cactttcttc gatatttact   923220
tggatttctc cgtctgaaaa ttgacgtgat gatagttttc caagtgggac accaacagct   923280
tgggcaattt tttgtgcaat ctcttggtta gagttgagtg cgaaaagttt catgtttttt   923340
ctatctgaca ttatagaccg tcctctgtaa actttataaa tcctagttat atttacctta   923400
catatatgaa ctgggatttg tgtattttta tcttttctat tttaccaaaa aatggagatt   923460
atttcagcta tttttcatac ttttgacaaa tcgaaccaat tttgaaggag ctttttgata   923520
ggaaatctga tttttctcta aaaattgtcg aaaatcctgt ttgccttgct catgattttc   923580
cacttcaagc tccaattcgt aatctgttat atcaaagtat cggctctgat ccagtgccat   923640
gagaccaata gctgttttca tttcatagcg aagcgttgtt agacaaccaa gaacctgcca   923700
gttcttactt tggataccat gtttcgccaa ttcatccagt actagccctt gaggaagttc   923760
ttccttactc agatagttct cagcatcttt tagttgcaat ttttggttgt attccatgtt   923820
tccaacactc tgcgggactt tgagtgtcaa ctcagcccag tcttcaaagg ttcgaatgcg   923880
catagcgact ttcttttctc gcagttcaaa atcaggcgtg tcgatgtagt aatttgtttg   923940
aagaacagga gtgacacctg tgaactggtc ttttagacga ttgtattcat cttttttcaa   924000
tagtgttttc aattcaattt ctaaatgttt catttttctt accttttttt atcgttgaaa   924060
gcggatttat ggtataataa gcattgtatt tattgtatat gaatctggag aaaaaatcaa   924120
agatattttt gacggataat atgagaacaa gggagaatat atgaccttag aatgggaaga   924180
atttctagat ccttacattc aagctgttgg tgagttaaag attaaacttc gtggtattcg   924240
taagcaatat cgtaagcaaa ataagcattc tccaattgag tttgtgaccg gtcgagtcaa   924300
gccaattgag agcatcaaag aaaaaatggc tcgtcgtggc attacttatg cgaccttgga   924360
acacgatttg caggatattg ctggcttacg tgtgatggtt cagtttgtag atgacgtcaa   924420
ggaagtagtg gatattttgc acaagcgtca ggatatgcga atcatacagg agcgagatta   924480
cattactcat agaaaagcat caggctatcg ttcctatcat gtggtagtag aatatacggt   924540
tgataccatc aatggagcta agactatttt ggcagaaatt caaattcgta ctttggccat   924600
gaatttctgg gcaacgatag aacattctct caactacaag taccaagggg atttcccaga   924660
tgagattaag aagcgactgg aaattacagc tagaatcgcc catcagttgg atgaagaaat   924720
gggtgaaatt cgtgatgata tccaagaagc ccaggcactt tttgatcctt tgagtagaaa   924780
attaaatgac ggtgtaggaa acagtgacga tacagatgaa gaatacaggt aaacgaattg   924840
atctgatagc caatagaaaa ccgcagagtc aaagggtttt gtatgaattg cgagatcgtt   924900
tgaagagaaa tcagtttata ctcaatgata ccaatccgga tattgtcatt tccattggcg   924960
gggatggtat gctcttgtcg gcctttcata agtacgaaaa tcagcttgac aaggtccgct   925020
ttatcggtct tcatactgga catttgggct tctatacaga ttatcgtgat tttgagttgg   925080
acaagctagt gactaatttg cagctagata ctggggcaag ggtttcttac cctgttctga   925140
atgtgaaggt ctttcttgaa aatggtgaag ttaagatttt cagagcactc aacgaagcca   925200
gcatccgcag gtctgatcga accatggtgg cagatattgt aataaatggt gttccctttg   925260
aacgttttcg tggagacggg ctaacagttt cgacaccgac tggtagtact gcctataaca   925320
agtctcttgg cggtgctgtt ttacacccta ccattgaagc tttgcaatta acggaaattg   925380
ccagccttaa taatcgtgtc tatcgaacac tgggctcttc cattattgtg cctaagaagg   925440
ataagattga acttattcca acaagaaacg attatcatac tatttcggtt gacaatagcg   925500
tttattcttt ccgtaatatt gagcgtattg agtatcaaat cgaccatcat aagattcact   925560
ttgtcgcgac tcctagccat accagtttct ggaaccgtgt taaggacgcc tttatcggcg   925620
aggtggatga atgaggtttg aatttatcgc agatgaacat gtcaaggtta agaccttctt   925680
aaaaaagcac gaggtttcta agggattgct ggccaagatt aagtttcgag gtggagctat   925740
tctggtcaat aatcaaccgc aaaatgcaac gtatctattg gacgttggag actacgttac   925800
cattgacatt cccgctgaga aaggctttga aaccttggag gctattgagc ttccattaga   925860
tattctctat gaggatgacc actttctagt cttgaataaa ccctatggag tggcttctat   925920
tcctagtgtc aatcactcta ataccattgc caattttatc aagggttact atgtcaagca   925980
aaattatgaa aatcagcagg ttcacattgt taccagacta gatagggata cttctggctt   926040
gatgctcttt gccaagcacg gttatgccca tgcacgatta gacaagcagt tgcagaagaa   926100
atctatcgag aaacgctact ttgctttggt taagggagat ggacatttgg agccagaagg   926160
ggaaattatt gctccgattg cgcgtgatga agattccatt attaccagac gagtggctaa   926220
aggcggaaag tatgcccata cttcatacaa gattgtagct tcttatggaa atattcactt   926280
ggtctatatt cacctgcaca ctggtcgaac ccatcaaatc cgagtccatt tttctcatat   926340
cggttttcct ttgctgggag atgatttgta tggtggtagt ctggaagatg gtattcaacg   926400
tcaggctctg cattgccatt acctatcctt ttatcatcca tttttagagc aagacttgca   926460
gttagaaagt cccttgccgg atgattttag taaccttatt acccagttat caactaatac   926520
tctataaaaa ctgtctcaga gtataattat tatcttaaag gagaaaactc atggaagttt   926580
ttgaaagtct caaagccaac cttgttggta aaaatgctcg tatcgttctc cctgaagggg   926640
aagagcctcg tattcttcaa gcaacaaaac gcttagtaaa agaaacagaa gtgattcctg   926700
ttttgcttgg aaatcctgaa aaaattaaaa tttatcttga aattgaagga atcatggatg   926760
gttatgaggt catcgaccct caacattatc ctcaatttga agaaatggtt tctgccttgg   926820
tggagcgtcg caagggcaaa atgactgaag aagatgtacg caaggttttg gttgaagatg   926880
tcaactactt tggtgtgatg ttggtttact tgggcttggt tgatggaatg gtgtcaggag   926940
cgattcactc aacagcttca acagttcgcc cagctctaca aatcatcaaa actcgtccaa   927000
atgtaactcg tacttcagga gccttcctca tggttcgtgg tacggaacgt tacctatttg   927060
gagactgtgc cattaacatc aatccagatg cagaagcctt ggctgaaatt gccatcaact   927120
cagcaatcac agctaagatg tttggcatcg aacctaaaat tgccatgttg agctattcta   927180
ctaaaggttc agggtttggt gaaagcgttg ataaggtcgt tgaagcaact aaaattgctc   927240
acgacttgcg tcctgacctt gaaatcgatg gtgagttgca atttgatgca gcctttgttc   927300
ctgaaactgc agctctgaaa gctcctggaa gtacggtagc tggtcaagca aatgtcttca   927360
tcttcccagg tatcgaggca ggaaatattg gttacaagat ggctgaacgc ctgggtggct   927420
ttgcggctgt aggacctgtt ttgcaaggtt taaacaagcc agttaatgat ctttctcgtg   927480
gatgtaatgc agatgatgtt tacaagttga ccctcatcac agcagctcaa gcagttcatc   927540
aatagtgaaa actataaagt gatatactat gctatactgt agttatgaaa ctatgtacga   927600
aaagcactgc cattaattcc tgagaactaa attactgatt ggtgtcaaaa aggaaaactt   927660
ccaagcgatg atatcctgtc tatacacgac ctatagaaat ctgtaatata catatccgta   927720
aaacgataaa ttcccttttt gattttaaat gagtatgaaa agagaatttt ttggctcttt   927780
gtcaactgta gtgggttgaa gaaaagctaa gctcgagaaa ggacaaattt catcctttct   927840
tttttgatat tcagagcgat aaaaatccgt tttttgaagt tttcaaagtt ccgaaaacca   927900
aaggcattgc gcttgataag tttgatgaga ttattggtcg cttccagttt ggcgttagaa   927960
tagtgtagtt gaagggcgtt gataatcttt tctttatctt tgaggaaggt tttaaagaca   928020
gtctgaaaaa taggatgaac ctgcttaaga ttgtcctcaa taagtccgaa aaatttctct   928080
ggttccttat tctggaagtg aaaaagcaag agttgataga gctgatagtg gtgtttcaag   928140
tcttccgaat agctcaaaag cttgtttaaa atctctttat tggttaagtg catacgaaaa   928200
ataggacgat aaaatcgctt atcactcagt ttacggctat cctgttgaat gagtttccag   928260
tagcgcttga tagccttgta ttcatgggat tttcgatgaa actgattcat gatttggaca   928320
cgcacacgac tcatagcacg gctaagatgt tgtacaatgt gaaagcgatc aagaacgatt   928380
ttagcattcg ggagtgaaac agcctgggag actgtttcag cctgagccta gaaatttgaa   928440
agcgaagctg tttagccaag tcatagtaag ggctaaacat atccatagta atgattttga   928500
cgcgacatcg gacggctcta tcatatttaa gaaagtgatc tcggatgaca gcttgtgttc   928560
taccttcaag aacagtgatg atattgagat tgttaaaatc ttgcgcaata aagctcatct   928620
ccatctcccg attgaaacag tcactccccg gactgtttca acgtcccaag acataatctt   928680
aggcagattt ctaaaattac actcaaagtg gaagtcattg agctttcgaa tgacagttga   928740
agttgagatg gaaagctgat gggcaatatc agtcatagaa atcttttcaa ttaacttttg   928800
agcaatcttt tggttgatga tacgagggat ttgatgattc ttcttgacga tagaagtttc   928860
agcaaccata attttagaac aatgatagca cttgaaacga cgctttctaa ggagaattct   928920
agtaggcata ccagttgttt caagataagg aattttagaa ggtttttgaa agtcatattt   928980
cttcatttga cttccgcact caggacaaga tggagcttca tagtccagtt tggcgatgat   929040
ttccttgtgt gtatccttat tgacgatgtc taaaatctgg atattagggt ctttaatgtc   929100
tagtaatttt gtgataaaat gtaattgttc catatgattc tttctaatga gttgttttgt   929160
cgcttttcat tataggtcat atgggacttt tttctacaca aaaataggct ccataatatc   929220
cataggggat ttacccacta caaatattat agagtcattt ttgcaccttt cttagccttt   929280
gttatcgaca agcattgttc tagctccttg tttttagaaa ggtaatttcc cagcgaaagc   929340
acccagtttt ttcttggtag tttcatcgat ttgttcaaga gcagagttga tggcttgaac   929400
ggtcatatca gaaagagtct caaggtcctc tgggtcaacg acagctggat tgaaatcaat   929460
gctgacaact ttcttatcgc cagttaaggt cgcttggaca agatcttgag cagatttgcc   929520
aacaaattgc atagcagcaa gttcagcttg gctttgttcc atttgttttt gaagtttttg   929580
tgcttgacgc atcatgtttt gcatgttcat cataagattt ctaaagttcc tttcatctca   929640
aggggataat ccttgttgtt aacaagtgcc tgattttctc tcctaattgt tattagtagc   929700
atagccatca agcccaagta ttgattttat tataccattt ttttaagaca tagtctttta   929760
ttggtgagag ttatttatgt caaggagtga ttagaaataa attaaaataa tgatttttgc   929820
taagagggct ctattctagt ttcatggaaa tgattttact aaaggttcgt atgctttgtt   929880
tgcaaacatg ttacatctat ctatttttgg ataaatagtt gtctattatt atttttatgc   929940
taatagtaaa atctaaatgg tagcctacga ttttttagaa agaaaatggt acaatatttc   930000
taagagaaaa tacaatggga ggtaaaatga ggttattacc tataagaaaa atatcacgtc   930060
agtctaaaag gttagcactt tttttgacgt tttgtgctgg atatgtggat gcttacactt   930120
ttattgttcg cgggaatacc cttgtagctg gacaaactgg aaatgttgtc tttctttcag   930180
tagaattaat taaaaataat gtttcggatg ttagggacaa ggttctcacc ttgctagcgt   930240
ttatgatggg agtcttttta ttaacgattt ataaggaaaa attgagaatt gtgaaaaaac   930300
ctattctgtc cttgattccc ttggcaatct tatcaatcat tattgctttt gtgccgcaaa   930360
ctgtggataa tatctatcta gtgccgccct tggccttctg tatgggactg gtgacaactg   930420
cttttggaga agtgtcgggt attgcctata ataacgcttt tatgacaggg aatatcaaac   930480
ggaccatgct ggcttttgga gattatttcc gaaccaagca cactcctttt ttgcgtgaag   930540
gattcatatt tgttagcctg cttagtagtt ttgtccttgg cgttgtcttt tcagcctatt   930600
tgacgatttt ctatcatgaa aagaccattc ttggtgttcc tattatgatg agcgtttttt   930660
acctcagcat gctttttgcc tcttggcaga aaaaagtaaa agaaaaagct tcattttagg   930720
tgttattact tgtaagaaaa taggagatat gctatacttg aagagttgac tatgcacgat   930780
cctgtgcaac cgcacgaaca tcgttgcttg attattcaag tttaagtggt tcgtcccacg   930840
atgctaggcg agtcttcaca aaaaatcggg gaaacccata aaaatcatag gaggtgcata   930900
atgagcacat acgcaattat caaaactggc ggaaaacaag ttaaagttga agttggtcaa   930960
gcagtttacg ttgaaaaatt gaacgttgaa gctggtcaag aagttacttt taacgaagtt   931020
gttcttgttg gtggtgaaaa cactgttgtc ggaactccac ttgttgctgg agctactgta   931080
gttggaactg ttgaaaaaca aggaaaacaa aagaaagtgg ttacttacaa gtacaaacct   931140
aaaaaaggta gccaccgtaa acaaggtcac cgtcaaccat atacaaaagt tgtcatcaac   931200
gcaatcaacg cttaatttta aggagaacac atgatacagg cagtctttga gagagccgaa   931260
gatggcgagc tgaggagtgc ggaaattact ggacacgccg agagtggcga atacggctta   931320
gatgtcgtgt gtgcatcggt ttctacgctt gccattaact ttatcaattc tattgagaaa   931380
tttgcaggct atgaaccaat cctagaatta aacgaagatg aaggtggcta tctgatggtt   931440
gaaataccaa aagatcttcc ttcacaccag agagaaatga cccagttatt ctttgaatca   931500
tttttcttag gtatggcaaa cttatcggag aactattctg agttcgtcca aaccagagtt   931560
atcacagaaa actaacacgg aggaaaacat tatgttaaaa atgactctta acaacttgca   931620
acttttcgcc cacaaaaaag gtggaggttc tacatcaaac ggacgtgatt cacaagcaaa   931680
acgtcttgga gctaaagcag ctgacggaca aactgtaaca ggtggatcaa tcctttaccg   931740
tcaacgtggt acacacatct atccaggtgt aaacgttggt cgtggtggag atgatacttt   931800
gttcgctaaa gttgaaggcg tagtacgctt tgaacgtaaa ggacgcgata aaaaacaagt   931860
ttctgtttac ccaatcgcta aataaaaagg tccattgaac cttttatccc gaaccttgaa   931920
atgtaaaggt gaggaagcta gaaacagctt aaaataaggc tttccgagtt ttcggagagc   931980
ctgttttttt gttttggtac ccatactttt taatatgtat agtggattga tactcttcga   932040
aaatcaaatt caaaccatgt caatttcacc ttgccgtact caagtacagc ctgcggctaa   932100
cttcctagtt tgcactttaa ttttcattga gtatgaatct ggaatagaac actgttaaac   932160
attgatatga gtttcctact cgatttcttc agattttatt tcaattgact ataagaactg   932220
ctatctggtt tcaaatattg gcttgtcgtc ccttcacttg tctgaatggc ttgagccgtt   932280
ccttctgata agggaaaaga tattctttag ctgaaacggt ctgagaatcc aagctaacag   932340
atggagagaa aaatagccca gtctgaagca cactagatgg gagttgttgg aaagcagtca   932400
tctagttttt ctttgctgtt ttggcttttt tctttgtcat tagggaaagt gacttgcttc   932460
aaatcaggga gtttaggaaa ttcttcaaac atcttgccca agttgtctca ttttgtaaat   932520
tttacagcca taggtgtacc tcgattctaa attctacctt ttcggcacca attagtaatt   932580
taaagttctc aggagttagt tgcattgctt tttcatacat aagcatagta tgacacttta   932640
tggttaccga acaagtctaa tcactccttg caaaattttg aagatgtcct acaagttttt   932700
gagaagaata ttgcaaagtt catagttaag caacgataga ataaagtgct ttttgaaaac   932760
aggtacactt catgtgaaaa aaacaacatt tcagattttc tgttccagaa atagctatcg   932820
ctatgatata attattttat gattattact attcctataa aaaaccaaaa agatattggc   932880
acaccatctg attcagtcgt tgttctcggc tattttgatg gcatacataa ggggcatcaa   932940
gaattatttc gtgttgccaa caaggctgcg agaaaggatt tgttgcctat cgtcgttatg   933000
acctttaatg aatctccaaa gatcgcttta gagccttatc atccagattt gtttttgcat   933060
attttgaacc ctgctgaacg tgaaagaaaa ttaaagcgcg aaggtgtaga agaattatat   933120
ctccttgatt ttagtagtca attcgctagt ctcactgcac aagaattctt tgcaacttat   933180
atcaaggcta tgaatgccaa aattattgtt gcaggttttg attatacatt tggttctgac   933240
aaaaaaacag cagaagattt aaagaattac tttgatggag aagttatcat tgttccacct   933300
gtagaagatg agaaaggaaa gattagttca actcgtatcc gtcaagctat tttagatgga   933360
aatgtgaaag aagcaggaaa acttttgggg gcaccgcttc catcaagagg tatggtggtt   933420
catggtaatg ctcgtggtcg tacaattggt tatccgacag cgaatttagt gcttttagac   933480
cgtacttata tgccagcaga tggcgtttat gttgttgatg ttgagattca aagacagaag   933540
tatcgtgcta tggctagtgt cgggaaaaat gtgacctttg atggagaaga agcacgtttt   933600
gaagtcaata tttttgattt taatcaagat atttatgggg aaaccgtcat ggtttattgg   933660
cttgatcgca ttcgagatat gaccaaattt gactcagttg accaattagt ggatcagtta   933720
aaggctgatg aagaagtaac tcggaattgg tcttaagagc ttgagtaaat aaaataaaaa   933780
agaggttgtc tgtaacccaa aagatagatg atttagtcta acttttgagg tcacgacatt   933840
acctcttttt attctttttc aaaggtgaag ccttctccta ggatttcatg ggcttctgta   933900
atagttataa aggcttgagg atcgattcga tgaatcattt ccttcgtttt cacaatttca   933960
tttcttccga caatacagta gatgattttc aaattttctt tactatagta gccttgacca   934020
gaaataaaag taacacctct tccgaggtca tcattaatcg ccttagcaag ttggtcagga   934080
cgttttgtga taatcataaa gcctttgccg gcatatcctc cttcaccaat caaatcaata   934140
acacgagaaa caataaaatc aaacaaaagc gtgtaggaaa ccaatctcaa atccttgaag   934200
attaggagaa tcaacatgag aatacaaaaa tctaagataa agagcagttt tcctatggat   934260
atatgagtgt atttgttgag aatacgagct agaatatcag ttccgccagt tgtacctcca   934320
gcattaaaaa taattccaag gccaattccc aataggattc ccgctataag ggctgtgatt   934380
agtaaatcac cttgaagatc aatatgaagg ggaatatgct caaaaaaagc taaccagccg   934440
gacaaagcta aggttcctag taaactagaa tagagggatt tggctccaaa aatcttccaa   934500
gctaggatga aaaggggaat attaatcagc aggttcatga gggaaacagg gattttaaaa   934560
agataaaagg tgatgagggt aatgcctgtc gcccctcctt caaagagatg atggggaact   934620
acaaaataag tcagtccaaa agcataaata gcagcaccta gtaaaatggt aaaaatgggg   934680
taaatttttt taatcatagg acacctcttt tcttataagt tgattatatc aaattttacg   934740
gaaaatttga ttgactccat taggattttt aatctttttt ttgatataat tagaagtaag   934800
gaaaccaatc tgaatcctaa aatagaaaga ttgatactat gacaaaaatt aagattgtaa   934860
ccgattcatc tgttactatt gaacctgaac tagtaaagca attagatatt acaattgttc   934920
cattatctgt aatgattgat aatgttgttt attctgatgc ggatttgaaa gaagaaggta   934980
aatttcttca gttgatgcaa gaaagtaaga atcttccgaa aacaagtcag ccacctgtag   935040
gtgtctttgc tgagattttt gaagacctat gcaaagatgg tggccagatt cttgctattc   935100
atatgtccca tgctctttcg ggtacggtag aagcagcacg ccaaggtgct agcctatcta   935160
ctgcagatgt gactgttgtt gatagttcct tcactgacca agccctgaaa ttccaagttg   935220
ttgaggctgc gaagttagct caagaaggta aagatatgga ggcaatttta tctcatgtag   935280
aagaggttaa aaaccataca gagctttata ttggtgtttc aactttggaa aatcttgtca   935340
aaggtggacg aattagccgt gtaactggct tgttgagctc tcttctcaat atccgtgctg   935400
tcatgcaaat gaaagaccat gaattgcagc caatggttaa aggtcgtgga actaaaacat   935460
ttaaaaaatg gttagatgag ttgataacat cgctttctga acgtgctgta gcagagattg   935520
gaatttcata ttctggtagt gatgattggg caaaagagat gaaagaaagc ttacaagctt   935580
atgttgaaaa gccaatttct gttttggaaa cgggttccat tattcaaact cacacgggtg   935640
agaacgcttg ggctattttg atacgttacc actcctaaaa aataaataaa atgggaagaa   935700
atagcgtttt taacttgacc taaaagggat tttaggatat gattatattt gttaattaga   935760
aattatttgg aggaatcatt aacatggcaa acaaacaaga tttgatcgct aaagtagcag   935820
aagctacaga attgactaag aaagactcag cagcagcagt tgaagctgta tttgcagcag   935880
tagctgacta tcttgcagct ggtgaaaaag ttcaattgat cggttttggt aactttgaag   935940
ttcgtgagcg cgcagaacgt aaaggtcgca acccacaaac tggtaaagaa atgacaattg   936000
cagcttctaa agtaccagca ttcaaagctg gtaaagctct taaagacgct gttaaataat   936060
cagtctttaa aaagcctatt gtatcaagct ttctagcttg gtcagtaggt tttttaatta   936120
tgaaatctag taataaatag agttaaaaag ttgaatgttc cgaaaatatt gtatatagta   936180
gactgaatct aaaatagtac gaaacaattg ctaaaacatt tatagaaatt aattttactt   936240
tcccaatcga tttgttctca tcttatttca atctgctata cgtacgtaaa tgatgaaaag   936300
aattaaataa tagacttgtg cgataactat ttgaaacaag attagctggt tagaaaatcc   936360
aacaagatag tgaagtaatc taatataaaa tatacataat ttagtttatt ttatgttata   936420
aaagttgtac taaaagactt acgattatct tgaatgcctt agggaaacat gctatactac   936480
ttgtatgatt attttacaag ctaataaaat tgaacgttct tttgcaggag aggttctttt   936540
cgataatatc aacctgcagg ttgatgaacg agatcggatt gctcttgttg ggaaaaatgg   936600
tgcaggtaag tctactcttt tgaagatttt agttggagaa gaggagccaa ctagcggaga   936660
aatcaataag aaaaaagata tttctctgtc ttacctagcc caagatagcc gttttgagtc   936720
tgaaaatacc atctacgatg aaatgcttca tgtctttaat gatttgcgtc ggacggagag   936780
acaactgcgt cagatggagc tggagatggg tgaaaagtct ggtgaggatt tggataaact   936840
gatgtcagat tatgaccgct tatctgagaa ttttcgccaa gcaggtggct ttacctatga   936900
agctgatatt cgagcgattt tgaatggatt caagtttgac gagtctatgt ggcagatgaa   936960
aattgctgag ctttctggtg gtcaaaatac tcgtttggca cttgccaaaa tgctccttga   937020
aaagcccaat ctcttggtct tggacgagcc aactaaccac ttggatattg aaaccatcgc   937080
ctggctagag aattacttgg taaactatag cggtgccctc attatcgtca gccacgaccg   937140
ttatttcttg gacaaggttg cgacaattac gctagatttg accaagcatt ccttggatcg   937200
ctatgtgggg aattactctc gttttgtcga attgaaggag caaaagctag ttactgaggc   937260
aaaaaactat gaaaagcaac agaaggaaat cgctgctctg gaagactttg tcaatcgcaa   937320
tctagttcgt gcttcaacga ctaaacgtgc tcaatctcgc cgtaaacaac tggaaaaaat   937380
ggaacgtttg gacaagcctg aagctggcaa gaaatcagcc aacatgacct tccagtctga   937440
aaaaacgtcg ggcaatgttg ttttgactgt tgaaaatgca gctgttggct atgacgggga   937500
agtcttgtca caaccgatta acctagatct tcgtaagatg aatgctgtcg ctatcgttgg   937560
tccaaatggt atcggcaagt caacctttat caagtctatt gtggaccaga ttccttttat   937620
caagggagaa aagcgctttg gcgctaatgt tgaggttggt tactatgacc aaacccaaag   937680
caagctgaca ccaagtaata cggtgctgga tgaactctgg aatgatttca aactgacacc   937740
agaagttgaa atccgcaacc gtcttggagc cttccttttc tcaggagatg atgttaaaaa   937800
atcagtcggc atgctatctg gtggcgaaaa agctcgtttg cttttagcta aattgtctat   937860
ggaaaacaat aactttttga ttctggatga gccgaccaac cacttggata ttgatagtaa   937920
ggaagtgcta gaaaatgcct tgattgactt tgatggaacc ttgctgtttg tcagtcatga   937980
tcgttacttt atcaatcgtg tggcaactca tgttttggaa ttgtctgaga atggttcaac   938040
tctctacctt ggagattacg actactatgt tgagaagaaa gcaacagcag aaatgagtca   938100
gactgaggaa gcttcaacta gcaatcaagc aaaggaagca agtccagtca atgactatca   938160
ggcccagaaa gaaagtcaaa aagaagttcg caaactcatg cgacaaatcg aaagtctaga   938220
agctgaaatt gaagagctag aaagtcaaag ccaagccatt tctgaacaaa tgttggaaac   938280
aaacgatgcc gacaaactca tggaattaca ggctgagctg gacaaaatca gccatcgtca   938340
ggaagaagct atgcttgagt gggaagaatt atcagagcag gtgtaaagat ggaacatctt   938400
ggaaaagtat ttcgtgaatt tcgaacaagt ggaaattatt ctttaaagga agcagcaggc   938460
gaatcctgct ctacctctca gttatctcgc tttgagcttg gggagtctga cctggcagtc   938520
tcccgtttct ttgagatttt ggataacatt catgtaacaa tcgaaaattt catggataag   938580
gcaaggaatt ttcataatca tgaacatgtg tctatgatgg cacagattat cccactttac   938640
tattcaaacg atattgcagg ttttcaaaag cttcaaagag aacaacttga aaagtctaag   938700
agttcgacga ctccccttta ttttgagctg aactggattt tgctacaagg tctgatttgt   938760
caaagagatg cgagttatga tatgaagcag gatgatttgg gtaaggtagc agattatctc   938820
ttcaaaacag aagaatggac catgtatgag ttgattcttt tcggtaacct ctatagtttc   938880
tacgatgtag actatgtcac tcggattggt agagaagtta tggagaggga ggaattttac   938940
caagagatta gtcgccataa gagattagtg ttgattttgg ccctcaattg ttaccagcat   939000
tgtttagagc attcttcttt ttataatgcc aactattttg aggcttatac agagaagatt   939060
attgacaaag gtattaagct ttatgagcgt aatgttttcc attatttaaa aggttttgcc   939120
ttatatcaaa aaggacagtg taaagaaggc tgtaagcaga tgcaagaggc catgcatatt   939180
tttgatgtgt taggtcttcc agagcaagta gcctattatc aggaacacta cgaaaaattt   939240
gtcaaaagtt aattttccca aataagggaa aaaataaaaa gctcctttcg gttttgatac   939300
aatagtttca aaatttgaga ggagctttaa tatgaatcgc tatgcagtgc agttgattag   939360
ccgtggggct atcaataaaa tgggaaatat gctctatgat tatggaaata gtgtctggtt   939420
ggcttctatg gggactatag gacagacagt tttaggaatg tatcagattt ctgagctcgt   939480
cacatctatt ctcgtcaatc cctttggcgg agttatttca gaccgttttt ctcgtcgtaa   939540
gattttaatg acggcagatc ttgtttgtgg gattctttgt ctggctattt ctttcataag   939600
gaatgatagc tggatgattg gcgctttgat tgttgctaac attgtgcagg ctattgcttt   939660
tgccttttct cgcacagcca ataaagctat cataactgaa gtggtggaga aagatgagat   939720
tgtgatctat aattctcgct tagagctggt tttgcaggtt gtaggtgtta gctctcctgt   939780
tctttccttc cttgttttac agtttgcaag tctccatatg acgctactgc tagactcgct   939840
gacttttttc attgcttttg ttctagtggc tttccttcca aaagaggaag caaaagttca   939900
agagaaaaag gcttttactg ggagagatat ttttgtagat atcaaggatg ggttacacta   939960
tatctggcat cagcaagaaa ttttcttcct tttgctggta gcttccagcg ttaatttctt   940020
ttttgcagct tttgaatttc tacttccctt ttcgaatcag ctttacgggt cagaaggagc   940080
ctatgcaagt attttaacta tgggggctat tggttccatc attggggctc ttctagctag   940140
taaaattaaa gctaatattt ataatctttt gattttactg gctttgacag gtgtcggagt   940200
ttttatgatg ggattaccac ttccaacttt tctttccttt tctggaaatt tagtttgtga   940260
attgtttatg acgattttta atattcactt ttttactcaa gtacaaacca aggttgagag   940320
cgaatttctt ggaagagtac tgagtacaat ttttacctta gctattctat ttatgcctat   940380
tgcaaaagga tttatgacag tcttgccaag tgtccatctt tattctttct tgattattgg   940440
acttggagtt gtagccttat atttcttagc tctcggatat gttcgaactc attttgaaaa   940500
attgatataa ggttgcttga gtttcaaaaa taatttcaaa ctaagtgttt tttccgccct   940560
tctcgtttgt gaggagggct tgttttatgg taaaatggtc ttatgaataa aagaatgaat   940620
gagttagtcg ctttgctcaa tcgctatgcg actgagtact ataccagcga taatccctcg   940680
gtttcagaca gtgagtatga ccgcctttac cgtgagttgg tcgagttaga aactgcttat   940740
ccagagcaag tgctagcaga cagtccgact catcgtgttg gtggcaaggt tttagatggt   940800
tttgaaaaat acagtcatca gtatcctctt tatagtttgc aggatgcttt ttcatgtgag   940860
gagctagatg cttttgatgc gcgtgttcgt aaggaagtgg ctcatccgac ctatatttgt   940920
gagctgaaaa tcgatggctt atctatctcg ctgacttatg aaaaggggat tttggttgct   940980
ggggtaacac gtggagatgg ttcaattggt gaaaatatca cagaaaacct caagcgtgtt   941040
aaggacatcc ctttgacttt gccagaagaa ctagatatca cagttcgtgg ggaatgttac   941100
atgccacgcg cttcctttga ccaagttaac caagcgcgcc aagaaaatgg agagcctgaa   941160
tttgctaatc ctcgtaatgc ggcagcagga actctgcgtc agttggatac agcagtagtt   941220
gccaagcgta atcttgcaac gtttctctat caagaagcca gcccttcaac tcgtgatagc   941280
caagaaaagg gtttgaagta cctagaacaa ctaggttttg tggtcaatcc taagcgaatc   941340
ttggctgaaa acatagatga aatctggaat tttatccaag aagtaggaca ggaacgggaa   941400
aatctgcctt acgatattga tggagtggta atcaaggtca acgacctagc aagtcaagaa   941460
gaacttggtt ttacagttaa ggctccaaag tgggcagtag cctacaagtt ccctgccgaa   941520
gaaaaagaag ctcaactctt atcagttgac tggacagttg gccgtaccgg tgttgtaact   941580
ccaactgcta atctaacacc agtacaactt gccggtacga ctgttagccg tgcgaccctg   941640
cacaatgtag attatattgc tgaaaaagat atccgaaaag acgatacggt cattgtatat   941700
aaggctggtg acatcatccc tgccgtttta cgtgtggtag agtccaaacg ggtttctgaa   941760
gaaaaactag atatccctac aaactgtcca agttgtaact ctgacttgtt gcactttgaa   941820
gatgaagtgg ccctacgttg tatcaatccg cgttgccctg ctcaaatcat ggaaggcttg   941880
attcactttg cttctcgtga tgctatgaat attacaggcc ttggtccatc tattgttgag   941940
aagctttttg ctgctaattt agtcaaggat gtggcggata tttatcgttt gcaagaagag   942000
gatttcctcc ttttagaggg agttaaggaa aagtccgctg ctaaactgta tcaggctatc   942060
caagcatcaa aggaaaattc tgccgagaag ctcttatttg gtttgggaat tcgtcatgtc   942120
ggaagcaagg ttagtcagct tttacttcaa tatttccatt caattgaaaa tctgtctcag   942180
gcagattcag aggaagtggc tagtattgaa agtctaggtg gcgtgattgc caaaagtctt   942240
cagacttatt ttgcgacaga aggctctgaa attctgctca gagaattgaa agaaactggg   942300
gtcaatctgg actataaagg acagacggta gtagcggatg cggccttgtc aggtttgacc   942360
gtggtattga caggaaaatt ggaacgactc aagcgctcag aagctaaaag taaactcgaa   942420
agtctgggtg ccaaagtgac aggtagtatt tctaaaaaga ccgacctcgt cgtggtaggt   942480
gcagacgctg gaagtaaact gcaaaaagca caagaacttg gtatccaggt cagagatgag   942540
gcatggctag aaagtttgta atggatcgtt taaaaacaga gtttagagaa tatgactatg   942600
tctgttaatt gagacgagat tgacaaaaat ttattagtga aatagaaaca aagtaaaaag   942660
gaaaaataaa aaatgtataa ctaccctatg cgcattcatt accatcgtaa gaatggagaa   942720
tatgacactt gctcctttgt aaaaagtcag gatcaacgaa ttgatttgct aacctacaaa   942780
gaagattatt ttggagcttt atttagcttt gaacacccaa gttcacatgt tatagaaagc   942840
ttgaattttg tggttcatac aggtcaaact agtaaagaat attctatccg ttttaatcac   942900
tatcccctat taacagaggt ctggattttg gaaggcgatg ataggattta ttactctgaa   942960
aatcctgcta ttgccagtcc tttctataaa aatcaaaatc cttttgcctt tgataaggcc   943020
attaacagtg ctagttttga tcatcattgg ggttaccaag gagaattggg ttgccgtgta   943080
gaggacaatc aggctcattt ttctctctgg tcacctacag cgacagaagt gcaagttgtc   943140
gtttatgaat cagctgctaa tgatgcaccc gtttggaaga cttttgagat gaaaagaggc   943200
aatagctact cttataatca taaggacaat acaatcggtg tctggagttt ggatgttgaa   943260
gaagatttgg taggtaagac ttatcagtat caagtccaat tccctcatca ccaaacactg   943320
acacgtgatc cttatacaat cgcgaccagc cctgatggca aacgttcagc tattctgagc   943380
catgtagaaa agcaagttga aaacttcgag gttaagcacg gttcggaggc tacttggcgc   943440
ttggaaaatc catgtaaggc agttatctgt gaaatgcaca ttcgtgattt gactaaatca   943500
cctacatcgg gtgtagatga acatcttcga ggaactttct tgggtgctgc tcaggctgga   943560
acagttaacc aatacggcca gtcaactgct tttgattaca tcaagaagct gggctacaat   943620
tatgttcaat tgcaaccaat tgcagaccgt cataaagaat acgatgagga tggaaatgta   943680
acctacaact ggggttatga tccacaaaac tataacgcgc cagaaactag tttttcaact   943740
aatccagatg atccagctca ggtcattcgt gatttgaagg tgatggttca agcttatcac   943800
gatgcgggta ttggagtcat tatggatgta gtctataacc ataccttctc agttgttgat   943860
gcaccattcc aaacaacagt ccctgattac tattatcgta tgaatccaga tggtaccttc   943920
cagaatggaa cgggtgttgg aaatgaaaca gccagtgaac acgaaatgtt tcgcaagtat   943980
atgattgatt ctcttctata ctgggtgcag gaatataata ttgacggctt ccgttttgac   944040
ttgatgggga ttcatgatgt caagaccatg cagatgattc gtcaaagctt ggatgaaatc   944100
gactccaaca ttatcctcta tggagaagga tgggatatgg gaacaggtct tgccccttat   944160
gataaggcca agaaggacaa tgcctaccag atgccaaata ttggtttctt taatgacaat   944220
cagcgcgatg ctgtcaaagg gggagaagtt tatggtgcta tcaagtcagg ttttgtcagt   944280
ggtgctgcga cagagccaat tctagctaaa gcaatcctag gaagtcgtga attaggaagc   944340
tatacacatc caaatcaggt gcttaactat gtagaagccc atgacaatta caatcttcac   944400
gatttattgg caacccttca tccagaccaa agttcagagc aaatcatgcg caaggtcgaa   944460
actgccacag ccatgaatct gctcatgcag gggatggcct ttatggaaat cggtcaagaa   944520
tttggtcgta ccaaactggt tgcgactggt gaaaatggtg agttgaccca tgatgataga   944580
gagcgtgcga tgaatagcta taatgctcct gacagtgtga accaagtgaa ctggaacttg   944640
attaatgagc gtcaagacag tattgagttt atccgtcaag tcatccgatt gaagacaaaa   944700
actggtgcct tttcttactc tagctatgat gaaatttacc atcatgtctt tgtgcattct   944760
gcgattgaac atagcggcta ccttatctat gaagttcacg gcaaagaaca cctcttggtg   944820
gttgtgaatg ctaaatcaga accctatcaa tttgaaaatg caggaaattt agctatgttg   944880
gtaaccaaca gtcgctcaaa agaagataat gttttaaatg atattagtct agctgtcttg   944940
agtgttttat aaataccatc tatctcgcta tttttacaca gacaaattcc cagttatgag   945000
tattagtaaa aaatccattc attgaaattg aaagaataga aagaacctgg ctaacagctc   945060
acttgtatag aaaatttgat aaatattttc acaaaacaag acctcctatc aaagtttttg   945120
aacacttgat aggaggtctt tttattatga agacttttac ctagactttg tttcagcaat   945180
ctatgacagt tatagtaggc tgaaattgga atagcacacc cttgtttctg aaacattgtg   945240
agaaattggt ttggctgtcc ccaaccaaat tgttcagttt ttttatttta ctatagatga   945300
tactcattca cgctcttcga aaatttcttc aaaccacatt agcctcgcct tgacgtagtg   945360
gattttttta atttttattg agtatacttt gaaaaatcaa gtttgtgaaa ataatctcaa   945420
aaattttgca aaaagggttg tgattttctg aaaatttggt aaaatatatc ttaatcattt   945480
tcaggaggac aaaaatttga caagatatca gaatttagta aatggaaaat ggaaatcatc   945540
tgaacaagaa attacgattt attcaccaat caatcaagaa gaattgggta cagttccagc   945600
catgactcag actgaagctg atgaggctat gcaagctgcg cgtgcagccc tgccagcatg   945660
gcgagcttta tcagcagttg aacgtgcggc ttatttgcat aaaacagcag ctattttaga   945720
acgcgataag gaagaaattg gtactatcct tgccaaagaa gtagcaaaag ggattaaagc   945780
agcaattgga gaagtagtgc gtacagcaga cttgattcgt tatgctgctg aggaaggtct   945840
ccgtatcact ggacaagcaa tggaaggtgg tggttttgag gcaacaagta aaaacaaact   945900
ggctgttgtc cgtcgtgaac cagttggtat cgtgctagcg attgctccct ttaattatcc   945960
agttaattta tctgcttcta aaattgcacc tgccttgatt gcagggaatg tggtcatgtt   946020
taagccacca acacaaggtt ccatttctgg actcttgttg gctaaagcat ttgaagaagc   946080
agggattccg gcaggtgttt tcaacaccat tacaggtcgt ggttcagaaa ttggggatta   946140
tatcattgag cacaaagaag tcaacttcat caactttaca ggttcaactc ctattggaga   946200
acgtattggt cgtttagctg gtatgcgtcc tatcatgttg gaacttggtg ggaaagatgc   946260
agctcttgta ctagaagatg cagatttgga acatgctgcc aagcaaattg ttgcgggagc   946320
ctttagctac tcaggacaac gttgcacggc cattaaacgt gtcattgttc tcgaaagtgt   946380
agcagataaa ttagctactt tgcttcagga agaagtttct aaattaacag ttggtgatcc   946440
atttgacaat gctgatatta cacctgttat tgacaatgct tcagccgact tcatttgggg   946500
cttgattgag gatgcacaag aaaaagaagc tcaggctctt acaccaatca aacgtgaggg   946560
caatcttctc tggccagtgc tttttgacca agttacaaaa gatatgaaag tggcatggga   946620
agagccattt ggtcctgttt taccaatcat tcgtgtggct agtgtagagg aagctattgc   946680
ctttgccaac gaatctgaat tcggccttca atcatcagtc tttacaaatg atttcaaaaa   946740
agcctttgaa attgctgaaa aacttgaagt aggtacagtc cacattaata ataaaaccca   946800
gcgtggtcca gataatttcc cattccttgg tgtcaaaggt tctggagctg gagtgcaagg   946860
aattaaatat agcattgaag cgatgacaaa tgtcaaatcc attgtttttg atgtgaaata   946920
acgtgtaaaa ccaggaaatt gttttcctgg ttttattttt ttgctataaa ataataataa   946980
ttatagaaaa aatacgaact ttttggtatt ataatagatt gaaaccagaa tagtacacct   947040
ctacttctaa aacattgtta gaaatcgatt tgactgtcct gatcgatttg tcctgttatt   947100
atttcatttt actatatata atacattgga gttaaaatag tacactttga tttctaagac   947160
attgttagaa attagattaa attccttaat cgatttgcgc atgttttatt tcatttcact   947220
atagtagaaa aagaaaggcg ttttcgcaat tttttgaaaa aatattgatt tacaattgaa   947280
cgagtaagtg aacttgttgt agattttcaa aataattaaa gaagtatagt aatttacttg   947340
aatcttctct aaaaaggtag tataataaaa acatagaaaa cgcttacagg agaaggggag   947400
tatatggata atagagaagc attaaaaacc tttatgacgg gtgaaaattt ttatctccaa   947460
cattatctag gagcacatag ggaagaacta aatggagagc atggctatac cttccgtgtt   947520
tgggcaccta atgctcaggc tgttcacttg gttggtgatt ttaccaactg gattgaaaat   947580
cagattccaa tggtaagaaa tgattttggg gtctgggaag tctttaccaa tatggctcaa   947640
gaagggcata tttacaaata tcatgtcaca cgtcaaaatg gtcatcaact gatgaagatt   947700
gacccttttg ctgtcaggta tgaggctcgt ccaggaacag gggcaatcgt aacagagctt   947760
cctgagaaga aatggaagga tggactttgg ctggcacgaa gaaaacgttg gggctttgaa   947820
gagcgtcctg tcaatattta tgaagttcac gctggatcat ggaaaagaaa ttctgatggc   947880
agtccttata gttttgccca gctcaaggat gaactcattc cttatctcgt tgaaatgaac   947940
tatactcata ttgagtttat gcccttgatg tcccatcctt tgggcttgag ttgggggtat   948000
cagcttatgg gttacttcgc tttagagcat gcttatggcc gaccagagga gtttcaagat   948060
tttgtcgagg agtgtcatac ccataatatt ggggttattg tggactgggt accagtcact   948120
ttaccatcaa cgatgatgcc ttagcctatt atgatgggac accgactttt gaataccaag   948180
accataataa ggctcataac catggttggg gtgcccttaa ttttgacctt ggaaaaaatg   948240
aagtccagtc cttcttaatt tcttgcatta agcattggat tgatgtctat catttggatg   948300
gtattcgtgt ggatgctgtt agcaacatgc tctatttgga ctatgatgat gctccatgga   948360
cacctaataa agatggcgga aatctcaact atgaaggtta ttatttcctt cagcgcttga   948420
atgaggttat taagttagaa tatccagatg tgatgatgat tgcagaagaa agttcgtctg   948480
cgatcaagat tacgggaatg aaagagattg gtggtctagg atttgactac aaatggaaca   948540
tgggctggat gaatgatatc ctccgtttct acgaagaaga tccgatctat cgtaaatatg   948600
actttaacct ggtgactttc agctttatgt atgttttcaa ggagaattat ctcttgccat   948660
tctcgcacga tgaagtggtt catggcaaga agagtatgat gcataagatg tggggagatc   948720
gttacaatca attcgcaggc ttgcgcaatc tctatacgta ccaaatttgt caccctggta   948780
agaaattgct cttcatgggt agcgaatacg gtcaattcct agaatggaaa tctgaagaac   948840
agttggaatg gtctaaccta gaagacccaa tgaatgctaa gatgaagtat ttcgcttctc   948900
agctaaacca gttttacaaa gatcatcgct gtctgtggga aattgatacc agctatgatg   948960
gtattgaaat cattgatgcg gataatcgag accagagtgt tctttccttt attcgtaagg   949020
gtaaaaaggg agaaatgtta gtctgtatct ttaatatggt acctgttgag cggaaagatt   949080
ttacaatcgg actacccgtt gcaggaattt acgaagaagt atggaatact gagttggaag   949140
agtggggagg cgtttggaaa gaacataatc aaactgttca aacgcaagaa ggactatgga   949200
aagattatga gcagacctta acctttaccc taccggctat gggagcaagt gtatggaaaa   949260
tcaaacgtcg cttgaaatct actaaaaccg tcacaaataa aaaccaaaaa ggagtagaaa   949320
atgaaaaatg aaatgttagc tttgattctt gctggtgggc aaggaactcg tctcggtaaa   949380
ctcactcaaa gcatcgcaaa accagctgtg caatttggtg ggcgctaccg tatcattgac   949440
tttgccctat caaactgtgc caactcaggg attcacaatg ttggggtcgt tacacagtat   949500
caaccacttg ctctcaacaa ccatattggg aatggttcaa gctggggact agacggtatt   949560
aattcaggtg tctctattct tcaaccttat tctgcaagtg aaggaaatcg ttggtttgag   949620
gggactagtc acgctattta ccaaaatatc gactatatcg acagtgtcaa tcctgagtat   949680
gtcttgattt tgtctgggga tcacatctac aaaatggact atgatgatat gctccagtct   949740
cataaggata ataatgccag cttgacagta gcagttttag acgtccctct taaagaagca   949800
agccgttttg gtatcatgaa cacagatgct aacaatcgta ttgttgaatt tgaagaaaaa   949860
ccagctcaac ctaaatctac aaaagcttct atgggaatct acatttttga ttggcaacgc   949920
cttcgtaata tgttagtcgc tgctgaaaag agcaaggttg gcatgtcaga ctttggtaaa   949980
aatgtcattc caaattacct tgagtcaggt gaaagtgttt atgcttacga atttagtggt   950040
tattggaaag atgttggtac tattgagtca ctttgggaag cgaacatgga gtatatttct   950100
ccagaaaatg ccttggatag tcgtaaccgt caatggaaga tttactcaag aaacttgatt   950160
tcaccaccaa acttcctcgg ggcaaatgct catgtggaag actcattagt tgtagacgga   950220
tgtttcgttg atggaactgt taaacattct atcctttcaa caggcgcgca agttcgcgaa   950280
ggagcggaag tccttgattc agttatcatg agtggagcta tcattggtca aggagctaag   950340
attaaacgtg ccattattgg tgaaggtgcg attatttctg acggtgtcga aattgatgga   950400
acagatgaag tacaagttgt aggatataat gaagtagtgg gggtagcaac agatgaagat   950460
tgataaatat tctgccattt taggaaatac agttggtttt cacaatatgt cgacattgac   950520
ggaccaccgt ccagtagcaa gtttgccatt tggtgggaaa tatcgtttga ttgacttccc   950580
actttcaagc cttgctaatg caggtgttcg tagtgtcttt ggtattttcc agcaggataa   950640
tatcagctca gtatttgacc atattcgttc aggacgcgag tggggcttat caacccttct   950700
tagccattac tatctaggaa tttacaatac ccgtgtagaa agtagtacag ttggaaaaga   950760
atactaccaa cagcttctta cttatttgaa acgttctggc tcaaaccaaa cggttgccct   950820
caactgcgat gttcttatta acattgattt gaaccaagtt ttccacctac atagtacaac   950880
aaaagagcct atcactgtag tttataaaaa actagctaag aaagatattt cagaagtaaa   950940
tgcaatcttg gatgtagatg aaacagacca tgttctttct cataaactct ttgatagcaa   951000
gtcaacagct gaaacgttca atatgtctac agatatcttt gtcgttgata caccttggtt   951060
gattgaacac ttggaagaag aagctaaaaa agaacatcca gagaaattgc gctatgtttt   951120
acgggatttg gctgtaaaag agggagcttt cgcctacgag tacacgggct atctagccaa   951180
tattcactct gttaaatctt attatcaagc gaatatcgat atgcttgaat cacaaaaatt   951240
ctattctctt ttctcaccaa accaaaagat ttatacaaag gtcaaaaacg aagagccaac   951300
ttactatgct aatacatcta aggtaagcac ttctcagttt gcctctggta gtattattga   951360
aggtcaagta gctaattctg ttctatcacg taatattcat gtccataagg atagcttggt   951420
taaagatagc ctgctcttcc ctcgtgttgt tattggagaa ggggctcagg tcgaatatgc   951480
tatcttggac aaaggggttg aagttgagca tggtgttgtg attcgaggaa ctgcagaaca   951540
tccagttgtg gttaagaaag gtgctaaagt aacagaggat attcattcat gaaaatttta   951600
tttgtagcag cagagggtgc acccttttca aaaacaggtg gtttgggaga cgtcattggc   951660
gctcttccaa aatcactggt aaaagctggg cacgaagttg cagtgatttt accctactat   951720
gatatggtag aggctaaatt tggaaatcag attgaagatg tgcttcattt tgaggtgagc   951780
gttggttggc gcagacagta ttgtggaatt aagaaaacag tattaaatgg tgtaaccttc   951840
tactttattg acaatcaata ttatttcttc cgtggtcatg tttacggtga ttttgatgac   951900
ggagaacgct ttgccttttt ccaactggct gccattgagg ctatggaaag gattgacttt   951960
attcctgatc ttctccatgt tcatgactac catacagcta tgattccttt cttgttgaag   952020
gaaaaatacc gttggattca agcctatgag gacattgaaa cagttttaac cattcataat   952080
ttagaattcc aaggacaatt ttcagaagga atgttgggtg atttgtttgg agttggcttt   952140
gaacgttacg ctgatggcac ccttcgatgg aacaactgtc tgaactggat gaaggcaggt   952200
attctctatg cgaaccgtgt ttcaaccgtt tcacctagct atgctcatga aattatgact   952260
agtcagtttg gatgtaattt ggatcagatt cttaaaatgg agtctggtaa agtatctggt   952320
atcgtgaatg ggattgatgc tgatctttat aatcctcaga cggatgctct tttagactat   952380
catttcaatc aggaagattt gtctgggaaa gccaaaaata aggcaaaatt gcaagaaaga   952440
gttggcttgc ctgttagagc agacgttcca ctggtgggaa ttgtttctcg tttgacacgt   952500
caaaaaggtt ttgatgtggt ggtcgaaagt cttcaccata tcttgcaaga agatgttcag   952560
attgttcttt tgggaactgg cgatccagcc tttgaaggag ctttctcatg gtttgctcag   952620
atttacccag acaagctatc aacaaatatc acttttgatg tcaaacttgc tcaggaaatc   952680
tacgctgctt gtgacctctt cctcatgcca agtcgttttg aaccgtgtgg cttgtctcaa   952740
atgatggcta tgcgttatgg aaccttgcca ttggtccatg aagttggagg cttgcgagat   952800
acagttcgcg ctttcaatcc aatcgaagga agcggtactg gctttagctt tgacaatcta   952860
tctccttatt ggttaaattg gactttccaa acagcattgg acttgtatag aaaccatcca   952920
gacatttgga gaaacctaca aaaacaagct atggagagtg acttctcatg ggatacagcc   952980
tgcaagtcat accttgactt gtaccatagt ttagttaatt aatagataaa atcgtatgat   953040
gacttcatac gatttttagg ctgtttagag aggagaactg atgtctcaag taaaaggctt   953100
gtgtgttttg gatgtagatg gaaccttaat cctagaagaa gtgattgatc ttttagggag   953160
agaggcaggt catgaggcgg aaatttcgca gattacaagt cgagcaatgc gaggagagtt   953220
ggtctttgaa agcagtttaa gaaaaagagt gtccttgttg gaaggtcttc ctattttggt   953280
ctttgataac gtcttcaact caattcatct atcgctaaat gtcccagagt tcatctctat   953340
tctccaaaag aatggcatcc tagttggtct ggtgtctggt ggatttacac caatagttgg   953400
agagattagc aaaatccctt ggtattgcct atttcactgc caactagctt gaagtcaaag   953460
aaggtctttt aacaggaaaa ttagttggac aaattataag tccccaggtc aaaaaagaga   953520
ctctggaaaa atggagaaag aaactaaaac tttctaaaga aagaacggtg gcaatcggtg   953580
atggggttaa taatctatta atgttgaagt cggcgaagtt aggaatcgcc ttttgtgcca   953640
aagaagtgct caaaaaagaa ataccacatc atgttgacaa gagggatttt ttagaagttc   953700
tccctttgat tgactgttta gaatgaggga aaatatgaag attgtaattg caccggattc   953760
gtttaaggaa agcttgacag ctcaacaggt agctgaagca ataaaaagag gcttccaaca   953820
atcgatagca gatgtagaat gtctcctctg ccctgttggt gatgggggag aaggtactgt   953880
agatgctatc cgacattctc ttgacctaaa agaaaaatgg atccaagtga cagacccttt   953940
tggacaaaaa gaagccatgc gctattttca aaaaggggaa ctggcactat ttgaagtagc   954000
tgacttggtt ggtcttggaa aaattccgct agagaaacga aatccacttc aaatccaaac   954060
ttgtggtatt ggagagttga ttcttcatct catctctaaa gggattaaag atatttatat   954120
cggtgttggt ggcacggcca gtaatgatgg aggactgggg attgctgctg gtttaggtta   954180
tcaattttat gatagggatg gaaatgtctt gcctgcttcc ggtcaatcct tattaaactt   954240
agcttctgtt tcaacagaaa attgctataa aattcctgaa ggtgttcaaa ttcatatttt   954300
agcagatgtc gtgagtccct tatgtggtca tcaaggtgcg acttacactt ttggcaatca   954360
aaaaggtcta catccgacta tgtttgcagt cgtagatcag gcgatccaag atttttatga   954420
aaaattctca cctgcaacat tagaaattaa aggagcagga gcaggtggag gccttgctgg   954480
tggtttgtgt gcctttgctc aggcaagtat cgtgtctgga attgatacct gcttggactt   954540
aatcaacttt gataagaaag tttcagatgc tgacttggtt gttgttggag aaggaagact   954600
tgatagtcaa agctttgctg ggaaagcgcc tataggtgtt gcaaaaagaa cccctgttgg   954660
agttcctgtt attgctattt gcggtagtct tgctgaagat ttacctcccc taccatttga   954720
aaatatccaa gctgtctttt ctattttgga gaaaagtgaa cctttagaag atagtttgaa   954780
aaatgccagt ttctatctgg agcgcacggc tgccaatatt gggcacttat taaatatgtg   954840
caagatttag ctaaaccatt tcttccataa ggatgttttg gctggttctt cctttttaac   954900
ttcccaaagt tttggaaaag caagtcgaag gtctttttct tctacttgaa ctggtgcatt   954960
gctatgaata accaggccaa aaggagaagt aatatgctct tcagatacta tggtggcttg   955020
actatcagtt tcttttgctt cttttaagta gaaaacttgc ttatcaaatt cgatagttgg   955080
tgaaatcttc acaaatagtg gctctgcttt ttcctgaagg ttttctaaaa taaataaaaa   955140
gcctttttct aactgagggc tatttgctgt gtcaatatct acatatccaa gaactctttc   955200
ctcaaaagta ccaagatagc gtctttgctc atccggattt atttttaacc caccatgagc   955260
tttttcaagt aattgttttg ataaatctgt catgaaaaca gtatatcata aaagttagaa   955320
taaaacagac aaaagaaagc gattacttta taaagttaag gaaaagttgc acaaagataa   955380
cgttttttct tgaaaaagga ggggttttaa ggtattatag aggtgtaaaa aatttaactc   955440
ataaggagag taaaaaatgt caattattac tgatgtttac gctcgcgaag tcctagactc   955500
acgcggtaac ccaacacttg aagtagaagt ttacactgaa tcaggtgctt tcggacgtgg   955560
tatggttcca tcaggagctt ctactggtga acacgaagca gttgaacttc gcgacggtga   955620
caaatctcgt tacggtggtc ttggtacaca aaaagctgtt gacaacgtaa acaacatcat   955680
tgctgaagct atcattggct acgatgtacg tgatcaacaa gctattgacc gtgctatgat   955740
cgcacttgac ggtactccta acaaaggtaa attgggtgcg aatgcaatcc tcggtgtgtc   955800
tatcgctgta gctcgtgctg ctgctgacta ccttgaaatc ccactttaca gctatcttgg   955860
tggattcaac actaaagttc ttccaactcc aatgatgaac atcatcaacg gtggttctca   955920
ctctgacgct ccaatcgctt tccaagagtt catgatcttg ccagttggtg cgccaacatt   955980
taaagaagcc cttcgttacg gtgctgaaat cttccacgct cttaagaaaa tccttaaatc   956040
acgtggtttg gaaactgccg taggtgacga aggtggattc gctcctcgtt tcgaaggaac   956100
tgaagatggt gttgaaacta tccttgctgc gattgaagct gctggatatg taccaggtaa   956160
agacgtattt atcggatttg actgtgcttc atcagaattc tacgataaag aacgtaaagt   956220
ttacgactac actaaatttg aaggtgaagg tgctgctgtt cgtacatctg cagaacaaat   956280
cgactacctt gaagaattgg ttaacaaata cccaatcatc actattgaag atggtatgga   956340
tgaaaacgac tgggatggtt ggaaagctct tactgaacgt cttggtaaga aagtacaact   956400
tgttggtgac gacttcttcg taacaaacac tgactacctt gcacgtggta tccaagaagg   956460
tgctgctaac tcaatcctta tcaaagttaa ccaaatcggt actcttactg aaacttttga   956520
agctatcgaa atggctaaag aagctggtta cactgctgtt gtatcacacc gttcaggtga   956580
aactgaagat tcaacaatcg ctgatattgc agttgcaact aacgcaggac aaatcaagac   956640
tggttcactt tcacgtacag accgcatcgc taaatacaac caattgcttc gtatcgaaga   956700
ccaacttggt gaagtagctg aatatcgtgg attgaaatca ttctacaacc ttaaaaaata   956760
atctctttat gtgattatag gctataaagc ctttgaaata agcactttgg ggcgctttcc   956820
cttagtgctt tttataattt aatacccttt ttactacccc tactaatttt tggtatagta   956880
agagggtagc ccggaaatgg gtcaccctta ttttttataa attgttgata gctgtttcat   956940
aatttgagac ggcttttttt gcattctctt ggttagtatg ccagtaagta ttttcagtga   957000
tcattaaatt agagtggcct aatctatact gaacatcttt cgggctaacc tgagcataga   957060
gcatcatagt agtatgtgta tggcggaaac catgaaatga tacgttagtt actccagcag   957120
catcaaaatg cttatttagg cgtttgcgta agttacaagc ataagcatat ttctccgtaa   957180
atacagagaa tacaactgtt tcagatcggc ctaatttcca agactgaatt tgttgacggt   957240
ttttgtattg tttcagtaaa agtaatgtgg ctttgtctat tggtatatca cgataaccag   957300
cgcttgattt aggtgagttt atttcctgat agcggtttag tgtcttattg atgctgataa   957360
caccgctttc taggtcaata tcagaccatt caagagccag agcctcacta atacggcaac   957420
cagtggccaa taaagtctta tacagaacaa catcaaataa gttctcataa tttgattgat   957480
ccagagcatc taaataatca agaaactgtt ttaattcttt gttgtctaag tatttgacag   957540
cagccttttc tttttgctgt ttgcgtggaa cgatgacatc attagctggg ttgtattgta   957600
ttacctggat agctacgcca tatttcaaaa tacgcttatt catgttatgg agcaaagagt   957660
agttagcaaa tgcccctttt tcgcctttat ttgccttgtc agcccatttg tttacttgct   957720
gttgaagaat aggcgtagta agtttagata gcttgtaatc gccaaataca ggcaataaat   957780
gcactctaac caatccctcc atggattggc gagtatttgg cttaactgta ttcttgtaac   957840
tatcccacca aacttttaca agctcattat atgttgtaat tgtcggcttg tctttaactg   957900
tatagccatt agcagcaaaa gtattgatcg catcacgcgc ttttacttta acgccctttt   957960
tagtggttgc tgtaacagtt gtacgggctt ttttgcccgt tagttggtca acgcctagat   958020
aaacactagc ataataaact ctttggccat tctttttgat tttttctttg atattcatgt   958080
atttgtacct ttctttccat cagcaggcaa ggcgcgtggt tttgttaggt atttatacat   958140
gagatcaacc agttagtttt tactaatttt gattgttcta tgttttgtta attgatcttc   958200
taaaatattt acagtgtaac cagaaacatc tatattctct aataaaaaac ttgattttaa   958260
tatatgttcc aaaattttag gaattacttt agaacgttgt cgaacgtacg tactaaatga   958320
aacaatttct gaaggtgcga tatagtcaat tttttttaaa gacgaattag gaatatcatt   958380
gccaaagaag ttaaaaaatc ttgctgtatt tatatcatca atatatatcg tttttgttga   958440
ctcgttcagt atagctagta aggcagtgta tagatatttt tctttatagg taagtctata   958500
cccaaaatag aaatattctc ggtttctagt acctccaaaa agtgaatagt caaaattaga   958560
taagttattt ttcaacaaat ttccttgcaa atctctcgat tgttcgatag ctaaatcaat   958620
aaattttttg atcgtttcgt ctgaaatttg ataatcaatc ttagaaatgg tattttgagc   958680
gatctgtaac gctttatttg ttatatcatc gtgtaaagag ttatactcat cataattttt   958740
tatacattca ggagctaaat ccataatctt taagtgtaga taagtattgt aatcgccgta   958800
gagtaactct tcaacactca tttttccaat agatgcaatt tttagtaggt tttctttatt   958860
tggtaaattg cgaccttttt cccagttgtt aactgtacct ttgctagtat taaatttttc   958920
tccaaatttt tccatagagt cgccatggct taaacggata ttttgaatac gttctccaac   958980
gagtttatta tttattttca tgttttacac ctccttaaag aacataataa acttttttta   959040
agaaaaagta aagaaaagta ttgactttat aaaaataaag ttttataatc taggtatgca   959100
aaagtaaagg aggtatagaa atgagtaaag aaaacaagat gcgtggatat aggaatatgc   959160
taggtttaac acaagagaaa cttggaaaaa aacttggtat atctaagcag agttattaca   959220
acaaagaaag tgggaagaca caattttcag ataaagaaaa acttaagatt aaaaatcttt   959280
taatcccttt atttccagat attacaatag aagatatatt ttttaaacag aagtatgcaa   959340
aagtaaagag tgcaaaaaat ggaattaaag cgaaaataaa agccgtgtac aggcgaccaa   959400
accaacgtac acggctaagg aaaaataaca aaactcaagc aaaggcaagg cgcgtggttt   959460
tgttaggtat ttagcaaggg gacaaacccc tttgtaaata atctcctctt attttatcaa   959520
aattagagga aaatgacaac ttaatttata aaaaggaaaa atggaggata taaatggaaa   959580
ttctgtctaa agaaatacag ttacagggct tacaacttct taaacagact cttgaaactt   959640
tagttgagct agaaaaacaa cgatctagta agttagattt aatttctcgt aaagaattaa   959700
tggatctgct aggtataagt gctacaaccc ttgataactg ggaggatctt ggtcttaaac   959760
gatatcagac tccgatggat ggagctaaga aagtattcta tcgtccgtca gatgtgtatt   959820
tatttttagc aataaaatag gagttatgaa atgaaaattg ttactttcaa accaactaaa   959880
caaatagacg atgggtttta tctgccaggt attgacattc tatttgtctc agacaaagca   959940
gatgccaagg ataaagaaga tgtaatttta tttctttcaa gaaatgggtt aaacaagtct   960000
tgaatgatat tagaaaataa atctactatt ccacggagga tatcgataca gcgatacaag   960060
tcgttataaa ggcctctaac acgtttatag agacaagtgg taaataatat taaccactag   960120
ccaaagccgt tttagaggct aaaaaagagg ctagaggagg caattaaaaa gtaagctaac   960180
cagatttata caggaggtag aaccgtaatg gaactagttt acatggacgg taagaaagag   960240
ccgtacacca caagcgagat catcgctgaa tgtgctgaag tacaacacca cactatcacg   960300
cgcttaataa gagaaaataa ggctgacttt gaagagttgg gaatacttgg atttaaaatc   960360
cataaattag atactagagg acaacctaaa aaatcctata ttctgaacga gcaacaggct   960420
acttttctga tcacttattt aaagaatacc gaaacagtac ggcaattcaa actaaaccta   960480
gtcaaagcat tctttgaaat gcgtgaggaa ctttctgaaa ttcgtctgca gagggcgcta   960540
gaaaaaccga aaagaaaaac cttgcatgac agtatagaaa catggcctaa tgcaccaaag   960600
cacgcgcata gcaccatgaa caacttgcta ctaaaggcag taacagacat gaacgctaag   960660
cagttaagag aagagcgtgg gggctataac ggtatcgata gcttgactag tgaggagttg   960720
gagcagtacc aggcatttga ggatatggca atagctatga ttgaattgaa aatgagttat   960780
caggaaatta agacaatgat gtttagaagt aaaaaaataa gctaaaaaat cacaccaaca   960840
aagaaacaga ggtaaaaaca tgacagaaac aacatatgag aatttaacta gacgtataga   960900
cagaattagc gcagaaatgc gagaaattag cgaagaaaat ggcctaagaa tcctttcttt   960960
attggaaagt cagacaaaat ccatcaaaga tgagttgtcc cgtttacttt ggattgaact   961020
tcctgaattg aatgaaagcc ataaaatcga agcggtctct aaaagcacta cgggaatgtt   961080
tttcgcccct ggtatttttg aaatggacgc tatgcgaaaa gcattcttta aacgccaagc   961140
taagcacttt tttgagaacg aagcagagca acaggcgtat atagagcatg ctgaaaagga   961200
gtatttagag gctactgtaa ccttaaaaga tattcttttt aactctaaaa atggaactca   961260
gaaagcaaat aaaagttgtc ttatagagaa gtttgaggag gcaatgcaat gacactagat   961320
ttagacaaca tgacacaagc agaatttgat gaggtaatgg ctgaaatcca gctacaaagt   961380
ccaaacattt ttcaactgat ttctgatttt gtaaataaaa aagtaaccag tgtggaaata   961440
gacgacttgt tgaatatgaa gcgagctgag acaggtaaag cattgtcacc gttacagatt   961500
caagaattgc agtatatgct agaagatttt agcccagagc ttatccatga ggcgttaaaa   961560
gaggctgtca gtcagggtaa agcaaacttt gcatacatca aggtaatcct taaccgttgg   961620
aaacaggaca atttattgac ggtggaactt gttagaaata gcagggcagc gcgtgaggct   961680
aaaaaacagc aaaccaatca actagagcct accagctatg aagattggat accaacacaa   961740
gaaaaaccat tttaggaggt cagaaaatga aatcattaca atctagttta ggaaatattg   961800
agacatttaa actagacgaa ttgtgtccta agcatgaaat acagctaaca caaatcaaag   961860
gagaaagaca tgtagtagtg gggtggaatg agaacggaga ggcaataaaa gaagttcgct   961920
gtatcccacc ctattgtgaa caatgccaag aagaacagaa aaagcaagat gaagaagatg   961980
cgattgctga taatttgaat gctaaactat atatgcaaac ttataatgtg ttgatgagca   962040
ataagagcta tgtagcagat gagtttaaaa ctaaaacttt tgatgatttt aatgctgtaa   962100
catcagaaga aaagcgattt ttagaatttg caaaaggtca ggtacaaaaa tatcttgatg   962160
gcatgagggg aaatacgctt atcacaggag gtacagggat tggaaaaaca cttttatcag   962220
ttgctattgc caaaggtata aatgaggggt ataagacaaa aggagaacct aagagtgtgc   962280
tttttgtaag cctaaccgaa atgatcaaac aaattaaaga ggggtggaat tatggtaaag   962340
gtgcaacact tacagagttt gaagctactg aactcatgaa gtctgttgat tacttaatta   962400
ttgatgattt aggagcaaaa aatgctgtta ttaagcctaa gagtgactgg gagcaggatt   962460
tactctttga cgtgctaaac aatcgtgaaa ataccatttt taataccaac ctagatagtg   962520
atgagcttaa gatagtttac aatgagcgga attatagccg tattctaaaa ggacttgagg   962580
gtaacacttt taaggcgttt ggcatcaaat ataagcggta ctcactcaat cagttaaaga   962640
gtaatatgtg acaatgaatt aacttacaaa cctaaacaaa aatagacact tttcatgggg   962700
tgagaaatcg ccctttgaga agtaatagcc atgctttcca cgaccatata aaccaagtgt   962760
ggcaaactaa ccaatttgaa aagtcagcca taaggtacac aaaaagggta gtattttagc   962820
atacgaaccc taaaaaccta gtgaaataaa tagactaggg gtattcagat tataataaaa   962880
tgaaataaag gagaaaagca tgactgaaaa caaggatgat aaattattaa aaatgatgga   962940
gaaaggcttt gttttatact caaaaaatgg tataattaag tatattgaaa ttccagagca   963000
tgggagtatt aagctaaaag ctcaagatgg gcaattagtt tataaggaag tgattatcgg   963060
gaaagtgtat gcagagcaag aacttttaaa atataaaaaa gagggcgaaa actattccca   963120
aaatactgct cagctattgt atcagcaact agaaaaagag aaaaatgctg aactagcaaa   963180
ccatgaatca aaagaagagc ctattacagc agatgatgca gctgaactaa gtttattatc   963240
tagtatcaaa ttaacagtgg cagaaatgag agaataccta gaaaaatata aaaataaacc   963300
tctagctctt agaaaattag aagatattat ggataatgat actacccttg cttatatcga   963360
aattgacatg gagcaattca gccaacagca acgccttgaa aagctagtac atttccttga   963420
tagaaaaatt gattatttcc acggtggttt acttattaac ggagataaga ttgatttagt   963480
acagcatgaa atgattgttg agggcaattc agaggcaatg gatgcagaat tgcagaatta   963540
tctagcatag ggaaataaag gggcaaccct ttattttgat aatgaggagg taatagatgg   963600
caggaaatga aaatgataac cttacgtcca agcaaattaa attcatagat gccatgctta   963660
ccgagccaac gatagacaaa gcatgtcaaa aagcaggggt atcacgcgca acaggtcata   963720
agtatctaaa agttgcagcg gttaaaaaga cattgaggat aaagcaagat gagatgatgg   963780
ataaaacaac tcaaatgctt tatttagcat catctaacgc tgtttctgta ctcaatgata   963840
ttatgatgga cagtaaggtc aacccgttta taagaactca agcagcaaag gctatacttg   963900
aacaatctta taagacccat gaaatttttg gagtagtaag gcagattgaa gaattgaggt   963960
tggaaattga ggaagtatct aaaggaaatc aaagagttac aagaactcaa ggagttatta   964020
agtaatagaa atatgccaga gtttattatt gttgaaggaa acaatgactt aggggaattt   964080
ttccaaatag atggcgagct atttagtgat aatgaacttt tagaaaacct taaaaaatgg   964140
cgtgagtggg aagtgccagt tattattgat gattggtgca atcgtatcct aaacgaggat   964200
gaaacggaaa tactatactt tcctactcat gaggataaga tgaactatat tagggtggaa   964260
aaagatttag aacctttgta tcatacatcg aacaagatct atgcaactat ttctaaaagt   964320
gagtggttag aattgttaaa ttgatgattt aggaggtagc aatgacaaag aagaaaattg   964380
agcgtatttc tgtaatacac cgagaaaaga ttttatggct caagtggtat ttcatgcgag   964440
ataaagaaca acctaagtat agtgtccttg agcgtaaaat gtttgatgct gctaaaaatc   964500
aagatatgct agcttatcaa aaatacgcaa ctatcaagca gataacagat attagggtac   964560
aaacaagtga ggctgacatt ttagaggctg taaaagaggt ttatgtgtac aatcacatga   964620
atgttatcgg agcttgtcag cggatattat ttatcagtca atcaccagct tatgataagt   964680
taaataagtg gtttaatatc tattctgatt tgtattttag cgttgtaccc ttgcccaaaa   964740
tgggggtata tcatgagatg gtaggtatct agttgattgt gtggtataat attctaaagc   964800
acaagggata gtatagaagg agtacacctt gatagaggta gccacggtgc gaatccgtgt   964860
cattgtgcta gcatctagga aactaggtgc tttttatttt aataacttaa aagtatttac   964920
aaacaataac ttttaggtta taattgttat taggaagagg tgttaatagt gcataatatc   964980
tatttttaca aggataaaaa cggcaatgag cctgtttttg attatatgcg agagcttacc   965040
agtaaaaaag ggaaagatag cagaattaag cttaataaaa ttaatgatta tattgagttg   965100
ttaagccaac atggaacacg cgcaggcgaa ccatatatta agcatttaga tgctgaaatt   965160
tgggagctga gaccacttag agatagaatt ttatttgttg cttggatgga tggtagtttt   965220
gttttactgc atcattttat gaaaaggaca cagaaaacac ccaaaagaga gattgagcaa   965280
gctaaacgtg aacttgcaga tttaaaagaa agaggtttag acaatgaaaa ataatgctat   965340
tggtagtaac tggaaagatg taagagctga attattcagc aaagaggaaa ttttggaaag   965400
tgatatgcgc gtggctatca tgagtgagct tatcgaggct agaaatgaaa agggtattag   965460
tcagaagaaa ctagaggaga tgagcggtgt tagtcagcca gttatcgcta gaatggaaac   965520
aggaaagaca agcccacaac ttgatacagt attaaaagtg ttggcaagtc ttggtaagac   965580
cttagctgtt gtaccattag agcatgagca ggtttagaaa gtttaggtga tattttgaca   965640
gcagaaattg gaatattaaa taaaaatggt gttgtattgg cttctgatag cgctgtaacc   965700
ttatcagacg ggaaaaattc aaaagttttt aatagcgccc gaaaattatt cactttatca   965760
aaagaacatt ccgtggggat catgatatat gggaacgctt cgtttatgga aattccgtgg   965820
gaggtaattt taaatgagtt taagcaggct attggcacag atttattaga taatactgcc   965880
caatacgttg aaaagctaat agaattttta atttccttta aacatctaca agttgaggat   965940
ttattaagaa attatattgt cagaagtaca agaagtattt tggacagcat tgcctatgaa   966000
gcgcaagaaa cagctgattt aagagtttct aatggtgaaa ccatcactct agatgatttt   966060
aataaaattt tattaaatgc tataactaat tttagtttag aaatttcaaa agtagaagct   966120
gaaagtaatt ttgaattttt tgaagctgag ttagagttaa taaaaagcat tgtagacgat   966180
gtttttaaat cctttcctca tactgatgat gaggttgaag ttattgctaa atctttatat   966240
aaagcgattt tcattggata tgactcaaca aacataactg gattagttat agcaggttat   966300
ggtacagacg agatatttcc atctataaga caaattgaat tatatggaat tttttctaaa   966360
cgattaattt ggaaagttat taatgaaagt gtgataaatc atcataaaac ttgtcatata   966420
atcccttttg cacagtcaga gatggttgag acgattatga atggtataga tcctaactta   966480
aatgtatata tcgcagagca agtatcatca gttatggaga aaaatggatt gggtgatgaa   966540
attgagaata tatttgaaaa tatatcatct atacagcaaa aatattatat aaatcctata   966600
atagacctta ttggaatgca accacttaat gaaatggcga gtacagctaa aacatttatt   966660
gaattaactt catttaagag aaaaattgtc aacactcttg aaacagtagg aggtccggta   966720
gatgtacttg ctatttctaa aggagaagga ccaatttgga ttgatagaaa atactatttt   966780
gacattgata aaaatcttga ttacaggatg agaaaggaga gttagttatg gatttcttaa   966840
accattcttt cgatactaaa aaagttatta atacaaaaat aaatgcagtt aactccaaaa   966900
ataatgttgg aaagaatttc atcgatgttt accgtgaaat gaaagaagtg ccaaacaata   966960
aaattcatca atcaaaagtt aacgtggcgt taattaaaaa atagcacccg taaaggtgct   967020
attttcttgc ctgctgaact catcgattta ataccttttt tactccccct ctagtatatt   967080
gtaattgttt gtactttaca ttttagaatg aaaaaggtaa aaagtatatt agtaatttag   967140
cgtatttaat tgaactattt gatattatga taaccttaaa aaataaaata gttcagtgaa   967200
ctattttatc ccgaaccatg aaattcaaaa gttcggccgt tgatttaaca acgtttctag   967260
cccctcggat tttatccgaa gggctatttt tgtatttaga gggcaaaaaa gggacaaaac   967320
tttttaaaaa atctttttca taactttatc cagtacattg attgcttcat ctttcatgtt   967380
ctttgtgacg tgggtgtaga tggaagtagt gacttcagag tcgggatgac caaccctgtc   967440
cgtgattgtt tttaaaggaa ttttattttc tgataagatg ctaatagtgg tgtgtctgaa   967500
gatgtgaggg gacagatgtt tgggaattgg ttttttaagg cgttcgtttg ctcgctggag   967560
agacttgctc aagatagaac tatgaactgt ttttcctgta ttggtaacaa aaatacggtc   967620
gcttttgtgc caattcttat cggttgtttc gcttagacaa tttatatagt caattgaaac   967680
aagaacaaga caaaaaagcc tcataaaagg tattgcaact tggtaatacc tttttgaggt   967740
gctttttgat atgagcccat gttttctcaa taggattgta ctcaggtgag tagggaggaa   967800
gaggtaaaag tttataccca aactcttcac acaagagttc tagcttcccc attctatgga   967860
atcttgcatt atccataata ataaccgatg gtgtggttaa tgttggtaag agaaacttct   967920
gaaaccaagc ttcaaaaaag tcgctcgtca tcgtctcttc gtaagtcatt ggagcgatta   967980
actcaccatt tgttagacct gcaaccaaag aaatcctctg atatcttctt ccagatactt   968040
tgcctcttat taactgacct tttaatgagc gaccatattc tcgataaaaa taagtatcga   968100
atcctgtttc gtcaatctaa acaggtgtta ggtgctttaa actattaaaa ttcttaagaa   968160
ataaggctac tttttctggg tcttgttcat agtaggtgtg gttctttttt cgagtgtagc   968220
ccatagcttt gagcgcatag tggatggtag ttggatgaca gccaaagtca gaagctattt   968280
cagtcaaata agcatctgga ttgtcagtaa gatagttttt aagtctatct ctatcaactt   968340
ttcttggttt tgttcctttt acttggtggt ttagctctcc tgttttctct tttagcttta   968400
accagccata aatggtatta cgtgagattt ggaaaacgtg tgatgcttct gttatactac   968460
ctgttcgctc acaataagag agaacttttt tacgaaaatc tattgaatat gccataagaa   968520
gattatacca cattgtgtac tatttttggt tcattttatt atagtagatt gaaataagat   968580
acgaatagct tgattaggga aatcaaatta atttctagaa atattttagc atccacggtg   968640
tactattata gtttcaattt actatagttc aatcattcta tcaagaatat tgaatatata   968700
aaggcacgta atattaaaac ttcttctgat atcgaattag agtccgatgt tgatggcgat   968760
aaatcagaca atctaccagt cgacattaag atactgggac aacacattga agtgtattcc   968820
gtacctaaga aacaatcata aaactcaaag ccttgttacc gaggcttttt tattatgtga   968880
ttttcagtag ccagacttat tctatctaat acaagtaaag ctaagtattt aagatttagc   968940
agatgatgaa gaaaagaaag gatggcctaa atattttaac agatttacga ggctaatcat   969000
ggtataatat agggtgatga aaaattccaa cgaggctgag atgaaattac tttatactga   969060
tattcggact tctttgacag aaattctaac aagagaggca gaagagctag ttgcagctgg   969120
caagcgggtc ttctacattg cccccaactc tctttctttt gaaaaggaac gcgccgtgct   969180
ggaatacttg tcccagcagg cttctttttc gattaccgtc acgcgctttg ctcaaatggc   969240
tcgctatctg gtcttgaatg atttaccagc taaaactact cttgatgata tcggtcttgg   969300
gttggccttt tacaaatgcc ttgccgaact cgatcccaag gacttgcgtg tttatggcgc   969360
tattaagcag gatcctcaat tgatccagca gttaattgag ctttaccatg agatgaccaa   969420
atctcagatg agttttttgg acttggagaa tttaacagat gaggataaga gggcggattt   969480
actcttgatt tttgagaaag taacagccta tcttaatcaa ggtcagttag cccaggaaag   969540
tcagttgtcc catttgattg aggctattga gaatgacaag gtaagtagtg attttaatca   969600
aatcgccttg gtcattgacg gctttactcg tttttctgct gaggaagagc gggttgtgga   969660
cttacttcac ggcaaaggtg ttgagattgt tatcggggct tatgctagta agaaagccta   969720
taccagtcct tttagcgagg gcaatctcta ccaagccagc gtaaaatttc tccatcatct   969780
ggcttctaaa taccaaacgc ctgctcagga ctgttctcaa actcatgaga agatggatag   969840
ttttgacaag gcctctcgtt tgttggagtc ttcttatgac ttttcagaac tcgctttgga   969900
tgtcgatgag aaagaccgtg aaaatttaca aatctggtct tgtttgacgc aaaaggagga   969960
gttggagcta gtagcccgta gtattcgtca gaaattacat gagaactcag acctgagcta   970020
caagcatttt cgtattctct tgggggatgt agcttcttac cagttatctc tcaaaaccat   970080
ttttgaccag tatcagattc ctttttatct tggtagaagc gaagccatgg ctcatcatcc   970140
cttgactcag tttgtcgagt ctattttagc tttaaaacgt taccgttttc gtcaggagga   970200
tttgattaat cttcttagaa ctgatttgta tactgacctc agtcagtctg atattgatgc   970260
ttttgagcaa tatatccgct atcttggtat caatggcttg ccagcctttc agcaaacctt   970320
caccaaatcc caccatggaa aatttaatct tgagcgtttg aatgtcctcc gcctgagaat   970380
tttagcacct cttgaaaccc tctttgccag ccgaaaacaa aaggctgaaa aactcctaca   970440
aaaatggagt gtctttctaa aagaaggagc tgtgaccaag cagttacaag atttgacaac   970500
cactttggaa gctgtagaac aggaaagaca agccgaagtt tggaaggctt tctgccatgt   970560
tttagaacaa tttgcgactg tttttgctgg ttcacaggtt agtctggaag acttcctagc   970620
cttgctccat tctggaatga gtttgtccca ataccgtacc attccagcaa cagtggacac   970680
tgttctggtg cagagttacg atttgattgc accattgact gctgactttg tctatgctat   970740
tggactaact caggacaatt taccaaaaat ttctcaaaac accagtcttc tgacagatga   970800
agaaaggcaa aacctaaacc aagcgaccga agaaggcgtt caattactga ttgccagcag   970860
tgaaaatctc aagaaaaatc gctacactat gctttccttg gtcaattctg ctcgtaagca   970920
gttgttcttg tcggctccaa gcctttttaa cgaaagtgaa agtaaggaat ctgcctatct   970980
tcaagagttg atccattttg gatttaggcg gagagagaag aggatgaatc acaaaggact   971040
gtctaaggag gatatggggt cctatcacag tcttttgtct agtctggttg cctatcacca   971100
gcagggtgag atgagcgata ctgagcaaga tttgactttt gtcaaggttc tgtcgcgtgt   971160
cataggtaaa aaactagatc agcaaggtct ggaaaatcca gctatcccaa ccagtccaag   971220
cagcaagacc ttagccaagg acaccttgca agctctctat cctgccaaac aggagtttta   971280
cctgtctacg tcgggtttga cagagtttta tcgcaatgaa tacagttatt tcctacgcta   971340
cgttttaggc ttgcaggagg aattacgttt gcatcctgat gcccgtagtc acgggaattt   971400
cttgcatcgt atctttgaac gcgccttaca gttgcctaat gaagattcct ttgaccaacg   971460
tctagaacaa gctattcaag aaaccagtca agaacgcgaa tttgaagcta tttatcaaga   971520
aagtttggaa gcccagttta ccaaggaagt tttgcttgat gttgcacgga caactggaca   971580
tattctccga cacaatccag ccatcgaaac catcaaagaa gaagcaaatt ttggtggaaa   971640
agaccaagcc tttattcaat tagacaatgg acgcagtgtc tttgtacgag gcaaggtgga   971700
ccggattgac cgtttgaaag ctaatggagc gataggagta gtagactaca aatccagtct   971760
gactcagttc cagtttcctc atttctttaa tgggctcaat tctcagttac caacctatct   971820
tgctgcccta aaaagagaag gggagcagaa ctttttcggc gccatgtact tggaaatggc   971880
tgaacctgtc caatctctga tggcggtaaa aagtctggca ggagcagtgg tagaagccag   971940
caaatctatg aaataccaag ggctcttctt ggaaaaagaa agcagttatt taggcgaatt   972000
ttataacaaa aacaaggcta atcaactgac agatgaggaa tttcagctcc tactggacta   972060
caatgcctat ctttacaaga aagctgctga gaagatttta gcaggccggt tcgccatcaa   972120
tccttatact gaaaatggca gaagcattgc cccatacgtc cagcaacatc aggctattac   972180
aggctttgaa gccaattacc atctgggcca agcccgtttc ctagaaaagt tggacctagc   972240
tgatggcaag cgtctggtcg gagaaaaact caagcaagct tggcttgaaa aaataagaga   972300
ggagttgaat cgatgaagct tattcccttt ttaagtgagg aggagattca aaaactgcaa   972360
gaagcagaag caaattcgag caaggaacag aagaaaactg ccgagcaaat cgaagctatc   972420
tacacttctg cccagaatat cctggtctca gcatcggctg gttctggaaa gacctttgtc   972480
atggcagagc gcattctgga ccaattggcg cgtggtgtcg aaatttctca actctttatc   972540
tcaaccttta ccgtcaaggc tgcaactgaa cttaaagaac gtttagagaa aaaaatcagc   972600
aagaaaatcc aagaaacaga tgatgtcgac ctcaaacaac acttgggtcg ccagttggca   972660
gacctaccca acgctgccat tggaaccatg gattctttca cacaaaaatt ccttggcaaa   972720
catggttatc tgcttgatat tgcacctaat ttccgtattt tacaaaacca aagcgagcaa   972780
cttattctcg aaaacgaagt ctttcatgag gtctttgaag cgcattacca aggtaaacag   972840
aaagagacct ttagtcattt gctgaaaaac tttgctgggc gtggcaagga cgaacggggt   972900
ctgcgccagc aggtctataa aatctatgac ttcctccaat ccaccagtaa tcctcaaaag   972960
tggctgagtg aatctttcct caaaggattt gagaaagctg attttaccag tgaaaaagaa   973020
aaactgaccg agcaaatcaa acaagccctt tgggatttgg aaagcttttt ccgttaccat   973080
ctggataacg atgccaagga gtttgcaaag gctgcctatt tagaaaatgt tcagttaatt   973140
ctggatgaaa ttggctccct aaatcaggag tccgatagtc aggcttatca ggcagtgctt   973200
gcgcgtgttg tcgccatctc taaggagaaa aacggtcgag ctctgactaa tgccagccgt   973260
aaggctgatt tgaagcccct ggctgatgcc tacaacgaag agagaaagac ccagtttgct   973320
aaactaggac aattatcaga ccagatagcg attctcgact atcaagaacg ttatcatgga   973380
gacacttgga aactagctaa aaccttccaa tctttcatga gcgattttgt agaggcttat   973440
cgtcagagaa aacgacagga aaatgccttc gaattcgctg atatcagcca ttacaccatt   973500
gagattttag agaatttccc acaagttcgt gagtcttatc aggagcgctt ccatgaagtc   973560
atggtcgatg agtatcagga taccaaccat attcaagaac ggatgctgga attgttgtct   973620
aatggccaca atcgctttat ggtgggagat atcaagcaat ccatctatcg tttccgtcag   973680
gcagacccgc agattttcaa tgagaaattc caacgctatg cgcaaaatcc ccaagaaggc   973740
aggctcatta tcctcaagga aaatttccgt agtagttcag aagtgctgtc agcaaccaat   973800
gatgtctttg aacgtctcat ggaccaagag gtcggcgaaa tcaactatga taacaagcac   973860
cagcttgttt ttgccaatac caaactgact cccaatccag acaacaaggc agcatttctc   973920
ctctacgaca aggacgatac aggtgaggaa gaagagagtc aaacagaaac gaaactaaca   973980
ggcgaaatgc gcttagttat caaggagatt ctgaaacttc atcaagaaaa aggtgttgcc   974040
tttaaggaaa ttgcccttct gacctccagc cgcagtcgta atgaccagat tctcctcgcc   974100
ctgtctgagt acggaattcc tgtcaaaact gacggagagc aaaacaatta tctccaatcc   974160
ctagaagtgc aagtcatgct agacactctt cgtgtcattc acaatcccct gcaagactac   974220
gccttggttg cccttatgaa gtctccaatg tttggttttg atgaggatga gctagcacgt   974280
ttgtcccttc agaaagcaga ggataaagtc cacgaaaatc tctatgagaa actggtcaat   974340
gcacaaaaaa tggcaagtag tcaaaaaggc ttgattcaca cagctctagc tgaaaaacta   974400
aagcaattca tggatatcct agcttcttgg cgcttgtatg ccaaaaccca ctctctctat   974460
gacttgattt ggaagattta caacgaccgt ttttattatg actatgttgg ggctttgccg   974520
aatggtcctg ctaggcaggc caatctctat gccctagcac tgcgtgctga tcaatttgaa   974580
aagagcaatt tcaaaggttt gtcgcgtttt attcgtatga ttgaccaagt cttagaagcc   974640
cagcacgatt tggcaagcgt ggccgtcgca ccgccaaaag atgcagtaga gctcatgacc   974700
atccacaaga gtaaagggct ggagtttcct tacgtcttta tcctcaatat ggatcaagat   974760
ttcaacaagc aagactctat gtcagaagtc attctcagtc gtcagaatgg tcttggtgtc   974820
aaatatattg ccaagatgga gacaggggca gtagaagacc actatcctaa aaccatcaaa   974880
ctctccattc ctagtctgac ctataggcag aacgaagagg aattacagct agcaagctat   974940
tctgagcaga tgcgtttgct gtatgttgct atgacgcggg ctgagaaaaa gctctatctt   975000
gtcggcaagg gttctcgtga aaagctggaa tccaaggaat acccagcagc caaaaatggg   975060
aaactaaata gcaatactag actgcaagca cggaatttcc aagattggct ttgggctatc   975120
agtaaagtgt ttactaagga caagctcaac tttagttatc gttttattgg cgaagatcag   975180
ttgaccagag aagctatcgg agagttggaa accaagagtc ctctccaaga tagctcccaa   975240
gcagacaatc gtcagtcaga taccatcaaa gaagctctgg aaatgctgaa ggaggtggaa   975300
gtttataata ctcttcaccg cgcagctatt gaacttccta gtgttcaaac cccaagtcaa   975360
atcaagaaat tctacgaacc agttatggat atggaaggtg tcgagattgc tggtcaaggt   975420
cagtcagtag gcaagaaaat cagcttcgat ttgccagatt tttcaaccaa agaaaaggta   975480
actggagctg agattggtag tgctactcac gaactcatgc agagaattga cctcagccag   975540
caactaaccc ttgctagcct aacagaaaca ctcaaacaag ttcaaactag ccaagctgtc   975600
agagacaaga tcaatcttga taaaattctt gctttctttg acacagtact cggtcaggaa   975660
attcttgcta ataccgacca tctttatcgc gagcaacctt tctccatgct caaacgagac   975720
caaaagagtc aggaagactt tgttgtccgt ggtatccttg atggctatct gctttacgaa   975780
aacaaaattg ttctgttcga ctacaagaca gaccgctatg atgaaccaag tcaactcgta   975840
gaccgctatc gtggtcagtt agctctatac gaagaggctt tatcacgagc ctattcgatt   975900
gaaaatattg aaaaatactt gattttactc ggtaaagacg aggttcaagt tgtaaaagta   975960
taacttatac tctttgaaaa tctcttcaaa ccacgtcagc ttcgccttgc tgtatatatg   976020
gttactgact tcgtcagttc tatccacaac ctcaaaacag tgttttgagc tgacttcgtc   976080
agttctatct acaacctcaa aacagtgttt tgagctgatt gcggctagct ttctagtttg   976140
ctctttgatt tttattgagt attagaaagg agacctcatg acacttccag ttagaaaatc   976200
cctgcacgat gcagttttac aggcttcgaa agcggatact tgggaacaag ctaccaagga   976260
atggaatgaa gtttccttta tttttaacgg tatcggccgt agcaattgtg tctgtggaaa   976320
tgccatcaaa tacgcttatg aactctttaa cggtgtcaca ggccaacgcc tctttccaat   976380
tggtagcgac tgtgttcgtc attttcatcg attgtccctt gaccagcaat tggaagagga   976440
agaaaaactg ctcagaaagg ttgaaaatct aaccagaaaa gctcagaaaa aggaaaaaat   976500
caaggtcaat aaaagtaact ttgacgagcg acttctaaaa tggctctggg aaaaaggtgt   976560
tttcaaaccc aatcgtggca atcaatttgc gcctgagaga gactaccagc ttttcctaga   976620
agtctttcag ggaggaagtt ggaccaaggc ggaaccaaag aaaaaggctc ggatggaaga   976680
agtccttgaa aagtgtatca aacccttttt acttgggaaa tcggatgacc aactctacct   976740
tgtcaagcta ggcaaggaga aaattgacta cgaacaagaa ctccgtatcc aggcagagaa   976800
agaacgcaag aagagggata aaatcgccaa gcaatatgca gacaatctgg ttctagccat   976860
gggacccgca gagcgtgctt atcaagatta ctttggcttt acagagaccc tgactcaaga   976920
agaacgcaag tgggaaaaaa ttctttttgg taaaaataga gcagaacgag ctatcaaggc   976980
caaacaatac caaaaagagc tggaaaaaga ccaacgaatt gccagtcagg atccaattga   977040
aagaaaacag aagcagactt ggatcctcaa ttcctatttt cgtgagcttc ctgaagaaaa   977100
agctcgattt tctagactct tattagaata tagaaaaagt ggtgaagtac ccttttcaac   977160
tgaatacctg tcagatcatc tcatcgactt tttctataaa atgaaagcct ttgaatttga   977220
aatcgcacca gaacaagtcc gagattttct aaaaaaaagc ctgcaggaag accatcgctc   977280
atcagcacaa ggaagctgga tagaaggaat tctcctcaac tgcctcaaac catttttaga   977340
acgattagtg atatgagtaa cacctaccgt gtaaatttca tggtaggtgt tattgtacct   977400
ccaaataata taaaacaaag tatgaaagcg catctcaatt ttaagacttt tttgtaaatt   977460
aagagtataa ttaaggtata ctgccttttc tatagataat agataataca ctaatataat   977520
aaaggtcttt gtaacatata taaattttat ttcaaggagg aataatggaa aagtattttg   977580
gtgaaaaaca agagcgtttt tcatttagaa aattatcagt aggacttgta tctgcaacga   977640
tttcaagttt attttttatg tctgtattag ctagttcatc tgtggatgct caagaaactg   977700
cgggagttca ctataaatat gtggcagatt cagagctatc atcagaagaa aagaagcagc   977760
ttgtctatga tattccgaca tacgtggaga atgatgatga aacttattat cttgtttata   977820
agttaaattc tcaaaatcaa ctggcggaat tgccaaatac tggaagcaag aatgagaggc   977880
aagccctagt tgctggtgct agcttagctg ctatgggaat tttaattttt gctgtttcca   977940
agaaaaaggt taagaataaa acggtattac atttagtatt ggttgcaggg ataggaaatg   978000
gtgtcttagt ttcagtccat gctttagaaa atcatctttt gctaaattac aatacggact   978060
atgaattgac ctctggagaa aaattacctc ttcctaaaga gatttcaggt tacacttata   978120
ttggatatat caaagaggga aaaacgactt ctgagtctga agtaagtaat caaaagagtt   978180
cagttgccac tcctacaaaa caacaaaagg tggattataa tgttacaccg aattttgtag   978240
accatccatc aacagtacaa gctattcagg aacaaacacc tgtttcttca actaagccga   978300
cagaagttca agtagttgaa aaacctttct ctactgaatt aatcaatcca agaaaagaag   978360
agaaacaatc ttcagattct caagaacaat tagccgaaca taagaatcta gaaacgaaga   978420
aagaggagaa gatttctcca aaagaaaaga ctggggtaaa tacattaaat ccacaggatg   978480
aagttttatc aggtcaattg aacaaacctg aactcttata tcgtgaggaa actatggaga   978540
caaaaataga ttttcaagaa gaaattcaag aaaatcctga tttagctgaa ggaactgtaa   978600
gagtaaaaca agaaggtaaa ttaggtaaga aagttgaaat cgtcagaata ttctctgtaa   978660
acaaggaaga agtttcgcga gaaattgttt caacttcaac gactgcgcct agtccaagaa   978720
tagtcgaaaa aggtactaaa aaaactcaag ttataaagga acaacctgag actggtgtag   978780
aacataagga cgtacagtct ggagctattg ttgaacccgc aattcagcct gagttgcccg   978840
aagctgtagt aagtgacaaa ggcgaaccag aagttcaacc tacattaccc gaagcagttg   978900
tgaccgacaa aggtgagact gaggttcaac cagagtcgcc agatactgtg gtaagtgata   978960
aaggtgaacc agagcaggta gcaccgcttc cagaatataa gggtaatatt gagcaagtaa   979020
aacctgaaac tccggttgag aagaccaaag aacaaggtcc agaaaaaact gaagaagttc   979080
cagtaaaacc aacagaagaa acaccagtaa atccaaatga aggtactaca gaaggaacct   979140
caattcaaga agcagaaaat ccagttcaac ctgcagaaga atcaacaacg aattcagaga   979200
aagtatcacc agatacatct agcaaaaata ctggggaagt gtccagtaat cctagtgatt   979260
cgacaacctc agttggagaa tcaaataaac cagaacataa tgactctaaa aatgaaaatt   979320
cagaaaaaac tgtagaagaa gttccagtaa atccaaatga aggcacagta gaaggtacct   979380
caaatcaaga aacagaaaaa ccagttcaac ctgcagaaga aacacaaaca aactctggga   979440
aaatagctaa cgaaaatact ggagaagtat ccaataaacc tagtgattca aaaccaccag   979500
ttgaagaatc aaatcaacca gaaaaaaacg gaactgcaac aaaaccagaa aattcaggta   979560
atacaacatc agagaatgga caaacagaac cagaaccatc aaacggaaat tcaactgagg   979620
atgtttcaac cgaatcaaac acatccaatt caaatggaaa cgaagaaatt aaacaagaaa   979680
atgaactaga ccctgataaa aaggtagaag aaccagagaa aacacttgaa ttaagaaatg   979740
tttccgacct agagttatac agtttgtcaa atggtactta taaacaacac atttcgttag   979800
agcaagttcc aagcaatcca aatagctact ttgttaaagt gaaatcttct tcattcaaag   979860
atgtatacct accagtagca tcaatatcag aggaaagaaa aaatgataaa atcctttata   979920
aaatcacagc aaaagtagag aagcttcagc aggagataga aagcagatat aaagataatt   979980
ttaccttcta tctagctaag aagggaacag aagaaacaac aaactttact tcctttagta   980040
atctggtcaa agctataaac caaaatccct ctggaaccta tcatttagcg gccagcctga   980100
atgctaacga agtggagctt ggtcctgatg aaagatccta tatcaaggac acctttactg   980160
gtcgtttaat cggtgaaaaa gatggcaaga attatgctat ctataatttg aaaaaacctc   980220
tgtttgaaaa cttgagtggt gctacagtag aaaaactgag tctaaaaaat gttgctattt   980280
cagggaaaga tgatatcggt tcactggcaa atgaagctca gaataacaca aaaattaagc   980340
aagttcacgt cgatggtgtt ctggctggtg aacgtggtat cggtggtttg ctggctaagg   980400
ctgagcaatc aagcatcaca gagagcagtt tcaagggaag aattatcaac acttatgaaa   980460
cgactgctgc ctacaatatc ggtggtatgg tcggtcattt gacaggtgac aaggctttac   980520
ttactaagtc aaaagcgaca gtagccattt catctaacac aaatacttca gatcagactg   980580
tgggtggact tgcaggccta gtagaccgag atgcacagat ccaagatagc tatgctgaag   980640
gtgatatcaa caatgtcaag cactttggta gagtcgctgg agtggcaggc aatttgtggg   980700
atcgaacttc tggtgatgtt aggcatgctg gaagtttgac caatgttctc agcgatgtta   980760
atgtaaccaa cggaaatgcc atcactggtt accactataa cgaaatgaag gtaaaggaca   980820
cattcagcag caaggccaac agagtctaca atgtcacctt ggtcaaggat gaggtcgtca   980880
gcaaggaatc ctttgaagaa agaggaacaa tgctagatgc ttctcaaatt gcaagcaaaa   980940
aagcagaaat caatcctctc attttaccaa cagtggagcc actttcaaca agtggcaaaa   981000
aagacagtga tttttctaag gtggcctatt atcaagctaa gcgcaacttg acttataaaa   981060
acattgaaaa attgctacct ttctacaaca aggcaaccat cgtcaaatac ggaaacctgg   981120
tcaatgagaa cagtctttta tatcaaaaag aactcttgtc agcagtcatg atgaaggaca   981180
accaagtcat cacagacatt gtttctaaca aacagactgc aaacaaactc ttgcttcact   981240
acaaggatga tttatctgag aagctggatc tcaaatacca gaatgatttc gccaaattag   981300
cagaatatag tctgggcaat actggacttc tctatacgcc aaaccaattc ctgtatgacc   981360
aaacctctat catcaagcaa gtcttacctg acttacaaaa ggttgactat cattcagaag   981420
ccatcagaaa gacgctgggt atttctccaa acgtcaagca aactgagctc tatctagaag   981480
accagttcgc caaaacaaaa caacaactgg aagacagttt gaaaaaactc ttgtcagcgg   981540
atgctggact ggctagtgct aaccccgtca ctgaaggtta tcttgtagat aaaatcaaac   981600
gcaacaagga agccttgcta cttggcttga cctatctgga acggtggtat aactttagct   981660
atggtcaggt gaatgtcaaa gacctagttc tgtaccattt ggacttcttt ggtaagggga   981720
atgcttcacc attagatact ctgattgagt tgggtaaatc tggctttaac aatcttctag   981780
ctaagaataa tgtcgatact tatggtatca gtcttgccag tcaacatgga acgacagatt   981840
tgtttagcac gctggaacat taccgaaaag tctttttacc aaatacaagc aataatgact   981900
ggtttaaatc agagactaag gcttacattg tcgaagaaaa atccactatc gaagaggtga   981960
aaacgaagca agggttagct ggcaccaagt attctatcgg tgtttatgat cgtatcacga   982020
gtgccacatg gaaataccgc aatatggtct tgcctctcct gaccttgcca gagagatccg   982080
tatttgtcat ctcgaccatg tctagtctag gatttggagc ttatgatcgc taccgcagta   982140
gtgaccataa agcgggcaag gctctcaatg attttgttga agaaaatgcg cgtgaaacag   982200
ccaaacgtca gcgagatcac tacgattatt ggtatcgtat tttagacgac aatgcacgtg   982260
aaaaacttta tagaaatatt ttgctttacg atgcttataa atttggcgat gataataccg   982320
tagggaaagc tacagaagtg gcagattttg ataatccaaa tcctgcaatg caacatttct   982380
ttggacctgt tggaaataaa gttgggcata atcaacacgg tgcttatgct acaggtgatg   982440
cagtttatta tatgggttat cgaatgttgg ataaggatgg agctattact tatacgcatg   982500
agatgacaca tgactcagat caggacattt atcttggagg atatggtcga agaagtggct   982560
tgggaccaga gttctttgct aaaggattat tacaagcacc agaccatcca gatgatgcga   982620
ccattaccat caactccatc ttgaaacatt caaaatctga tagtacagaa agtcgacgat   982680
tacaagtact tgatccaact acaagattta ataatgcaga tgatttgaag caatatgtcc   982740
acaacatgtt tgacgttgtt tatatgttgg aatatctcga aggaaattca attcttaaat   982800
tggatacgaa tcaaaaacaa caacttctta gaaaagttac aaatgagtac catcctgatc   982860
ctgatggaaa taaggtctat gcaacaaatg ttgtcagaaa tctaacagta gaagaagttg   982920
aaagactacg ttcattcaat gatttgattg ataataatat tctttcgtct agggaatatg   982980
cctcaggtaa atacgaaaga aatggctact tcactattaa gttatttgca ccgatttatg   983040
ctgcattaag taatgatata ggaacaccag gtgacctgat gggacgtcgt atagcctatg   983100
aactactagc tgctaaaggc tttaaagatg gtatggtacc atatatctca aaccaatacg   983160
aagaagaagc caaacaaaag ggcaagacaa tcaatctcta cggtaaaaca agaggtttgg   983220
ttacagatga cttggttttg gaaaaggtat ttaataacca atatcatact tggagtgagt   983280
ttaagaaagc tatgtatcaa gaacgacaag atcagtttga tagattgaac aaagttactt   983340
ttaatgatac aacacagcct tggcaaacat ttgccaagaa aactacaagc agtgtagatg   983400
aattacagaa attaatggac gttgctgttc gtaaggatgc agaacacaat tactaccatt   983460
ggaataacta caatccagac atagatagtg aagtccacaa gctcaagaga gcaatcttta   983520
aagcctatct tgaccaaaca aatgatttta gaagttcaat ttttgagaat aaaaaatagt   983580
gtctactatt aggaaataaa gtttaaaaag gtgatgaaga acaaaccaag attcaagcag   983640
gaattcctac tgataatgaa gtaagttatg atcttattta tcagcaggaa actcttcctg   983700
caacaggttc atcaacttct gagcttacag ctttaggcct attagctgtt ggtagtttag   983760
ttcttttggt tcataatatg acgggaacag ttttttgctc cctctgaaaa gtcatcattt   983820
gatggctttt ttctatatag ggtaaaagat agggtaaaag gctatcatcg gacaaaataa   983880
agaaggcatg atataatata aagtagattt ctatgtcata aaacaagaac tgtttggaca   983940
tcattcattt gaaaactctc tatgttcaaa caatagtaaa ataaaatagg ggatctaaat   984000
ccttgctatg aaaggaaaaa actcaatggc tactattcaa tggtttcctg gtcacatgtc   984060
taaagctcgt cgacaggtgc aggagaattt aaaatttgtt gattttgtga cgattttagt   984120
agatgcacgc ttgcctctat ctagtcaaaa tcctatgttg accaagattg ttggtgataa   984180
accaaaactc ttgattttaa acaaggccga cttggctgat ccagcaatga ccaaggaatg   984240
gcgtcagtat tttgaatcac aaggaatcca gacgctagct atcaactcca aagagcaagt   984300
gactgtaaaa gttgtaacag atgcggccaa gaagctcatg gctgataaga ttgctcgcca   984360
gaaagaacgt gggattcaga ttgaaacctt gcgtactatg attatcggga ttccaaacgc   984420
tggtaaatca actctgatga accgtttggc tggtaaaaag attgctgttg ttggaaacaa   984480
gccaggggtc acaaaaggtc aacaatggct taaaaccaat aaagacctgg aaatcttgga   984540
tacaccgggg attctctggc ctaagtttga ggatgaaact gttgcactta agttggcatt   984600
gactggagct atcaaagacc agttgcttcc tatggatgag gttaccattt ttggtatcaa   984660
ttatttcaaa gaacattatc cagaaaagct ggctgaacgc ttcaaacaaa tgaaaattga   984720
agaagaagcg cctgtgatta ttatggatat gacccgcgcc ctcggtttcc gtgatgacta   984780
tgaccgtttt tacagtctct tcgtgaagga agtccgtgat ggcaaactcg gtaactatac   984840
cttagataca ttggaagacc tcgatggcaa cgattaaaga aatcaaagaa ttccttgtga   984900
cagtcaagga gttagaaagc cctatttttt tagagcttga aaaggataat cgctcaggag   984960
ttcaaaagga aatcagcaag cgtaaaagag ccattcaagc tgaattagat gaaaatttgc   985020
gcttggaatc catgctttct tatgaaaaag aactttataa gcaaggattg accttaattg   985080
caggtattga tgaggttggt cgtggtcctc ttgctggtcc tgtagtcgct gcggccgtta   985140
ttttatctaa aaattgtaag attaaaggtc tcaacgacag caagaaaatt cctaaaaaga   985200
aacatctgga gattttccaa gccgttcaag accaagcctt gtcgattgga attggtatca   985260
tagataatca ggtcatcgac caagtcaaca tctatgaagc aaccaaacta gccatgcaag   985320
aagcaatctc ccagctcagc cctcaaccag agcacctttt gattgatgcc atgaaactgg   985380
acttgcccat ttcacaaacc tccattatca aaggagatgc caactccctc tctatcgcag   985440
cagcatctat agtagccaag gtaacacgtg atgaattgct gaaagaatac gatcagcagt   985500
tccctggcta tgatttcgct actaatgcag gatatggcac agctaaacat ctggaaggcc   985560
tcacaaaact aggagttacc ccaattcacc gaaccagctt tgaacccgtt aaatcactgg   985620
ttttaggtaa aaaagaaagt taattgaaag gaaataacat ggaggaacag tcggaaatag   985680
tccgttctaa gaaagaattc gcctttgcat ccagcactat actatcccaa gttggtcgag   985740
gaatcattgt cggcctcatc gttggaatta tcgtcggatc ctttcgtttc ttaattgaaa   985800
agggcttcca cctgatacaa ggagtttatc aagatcaagg gtacttagtg cgcaatcttt   985860
ttgtactggt tttgttttat atactcatct gttggctcag tgccaaacta acacggtcag   985920
aaaaagatat taaaggctca ggaattcctc aagtcgaagc cgaactgaaa ggcctcatgt   985980
ccctcaactg gtggggcatt ctttggaaaa aatatgtgct aggtattctt gctattgcca   986040
gtggactcat gctgggtcga gagggaccca gcattcaact tggagcagtt ggtggtaaag   986100
gaattgccaa gtggctcaaa tccagtccag tagaggaacg ttccttgatt gccagtggag   986160
ctgcagcagg tttagccgca gcctttaatg ctcctattgc agcacttctc tttgttgtag   986220
aagaagtcta tcaccatttt tcgcgctttt tctgggtctc aactctagca gccagcatcg   986280
tagcaaactt tgtgtctcta ctcatgttcg gtttgacacc agtattggat atgccagata   986340
acattcctcc catgacccta gatcagtatt ggatatatct cgtcatggga attttccttg   986400
gattttcagg ttttctctat gagaaagctg tattaaacgt tggaagagtt tatgacttga   986460
ttggtcaaaa aatccatttg gatagggctt attatcccat cttggctttt atccttatca   986520
taccagtcgg aatcttctta cctcaaatca ttggtggcgg aaatcagctt gtcctttctt   986580
taactgaaca aaattttagt ttccaagttt tattagctta ctttttaatc cgctttattt   986640
ggagtatgat tagctatgga agtggactgc caggaggaat tttcctcccc attttagctc   986700
ttggttcttt gcttggtgcc ttagttggtg ttatctgtgt caatcttgga cttgtcagtc   986760
aagagcaatt ccctatattt gtcattctag gaatgagtgg ctattttgga gccatatcaa   986820
aagctccctt aaccgctatg atcctcgtaa ctgagatggt aggagatatt cgcaacctta   986880
tgccacttgg tcttgtcact cttgtttctt atattatcat ggatttgctc aaaggtacgc   986940
cagtctatga agccatgctg gaaaaaatgc ttccagaaga agtatctagc gaaggagaag   987000
ttacacttat cgaaatacca gtttctgata aaattgctgg gaaacaagtt catgaactca   987060
acttaccaca caacgtcctc atcacaactc aagtccataa tggcaagagc caaacagtta   987120
acggctcaac cagaatgtat ctgggtgata tgattcacct ggttattcca aaaagtgaaa   987180
ttggaaaagt caaagatttg ttgttgtagt atgagtattt acataattta tgttatgtaa   987240
atgatcagtt tgatttattt agaaaaccga ttctcaggaa tgagatcggt tattttttac   987300
tgatgaggaa ttttacatat aaataattga actttattaa aaataagact ataattaagt   987360
tagaaatgat aaagtataaa gctagaaagg agtttactgt atcaaatctg tacagtaaga   987420
ttaaaatcat gaaaaagaaa acaatagcaa ttatatagag aaatgaaata gaaataggat   987480
aaaacaatca ggacaatcaa atcaatttct agcaatgttt tagaagtcca gatgtactat   987540
tctagtttca atctattata caatgtgttt tgtatctcat agctccttat atagctcttc   987600
agttatgtag tattaacaga agtttagtgg gtgagatttt tattattttc cttattctgt   987660
tttgtttgta ggtctaagtc tttttatcac tttgaaaaac tcctataaca tctttccgaa   987720
aaactataat tttcttgaaa aatatacaag tctatgctat actactagta tacttactta   987780
tggagaaaat acatgaaacg tgagatttta ctggaacgaa tcgacaaact aaaacaactc   987840
atgccctggt atgttctgga atactaccaa tctaagctgg ctgtgcccta cagttttaca   987900
accctgtacg aataccttaa ggaatatgac cgatttttca gctgggtttt ggagtctggt   987960
atttcaaacg ctgataaaat atccgatatt cctttatcag ttttggaaaa tatgtctaag   988020
aaagacatgg aatcctttat cctttatcta cgtgaacgtc ccttgctgaa tgctaataca   988080
acaaaacaag gtgtttcaca gacaactatc aatcgaacct tatcagcact ttctagtctt   988140
tacaagtatc taaccgagga ggttgaaaac gatcaggggg aaccttattt ctatcgtaat   988200
gtaatgaaaa aagtttccac caagaaaaag aaagaaaccc ttgctgccag agctgaaaat   988260
atcaagcaaa aactctttct aggtgatgaa acagaaggtt ttctaactta tatcgatcaa   988320
gagcacccac aacagctttc aaatcgagct ctctcatcat tcaacaaaaa taaagaacga   988380
gatttagcca ttattgccct tctcttggca tctggtgttc gcttatctga agctgttaat   988440
ctagatctaa gagatctcaa tctaaaaatg atggttattg atgttactcg aaaaggttgc   988500
aaacgtgact cagtcaatgt cgctgctttt gctaaacctt atttagagaa ttatctggcc   988560
attcggaatc aacgctataa aacggaaaaa acagatacag cccttttttt aactctctac   988620
agaggtgttc ctaatcgtat cgatgcttct agcgttgaga aaatggttgc taaatactca   988680
gaggatttta aagtgcgtgt aacaccccat aaactgcgcc atacactagc aactaggctc   988740
tatgatgcga ctaaatcaca agttttagtc agtcaccaac taggacatgc tagcacacaa   988800
gtcactgacc tctataccca tattgttagt gatgaacaaa agaatgctct ggatagttta   988860
tgattttacg tattttaaat tatgtaaata aatatcaaaa aaagaagttg gccaacttct   988920
ttttgattta tccaactacc gcttcagcga tttcttcacg gctaatacca gcgaagtagc   988980
gtgtgatatc aatggttttt agcgccttaa gaacatcttc gcgttcgtat ttcaccccac   989040
gaaggacatc ttctactgca gcaacgtctt caataccaaa gaagtcacca taaatcttga   989100
tgtcttggat ttttgattca gtaacgttag caaagacttc aaccttacca ctagtgaatt   989160
tgattccacg acggacgtta aattcaggtg atttaccata gttccagtcc caagttccaa   989220
acttagtatc cttgatgcga ttgatttcgg ccaattcttc ttctgaaaag acgtattcag   989280
tcatctctgg gtactctttt ttcatgtatt ccaagagtaa atcacggaat ttttcgactg   989340
tgattttttt tggtaattca ttgataatat tggttacacg ggcacggacg gatttcacac   989400
cttttgattc aaatttatct tttgaaacct taagggcatt tgcgaggact gacaaatcaa   989460
cgtcaaagag caagcaaccg tggtgcatga tacggccgtt gatataggct tgggcattgc   989520
cacagaactt cttaccatca atctcaaggt cattacgacc tgtgaactca gctttaaccc   989580
caagttgagc cagggtattg ataaccggag ttgagaagct cttgaagtca aatgccttat   989640
tttcatcttc tttggagatg atcgtgtagt tgaggttatt taaatcgtgg taaacagctc   989700
caccaccact aatacggcga actacctcaa taccattttc gcgaacataa tcacggttga   989760
tttcttcgat agtgttctgg tgacgaccaa caatgataga tggcttgtta atccaaagta   989820
ggaagatttg atcctcatcc aaaaggtgtt taaaggcgta ttcttccaag gcaatattaa   989880
aagcagtgtc atttgaatga ttgataatgt atttcatgat atccctttac tttatatgat   989940
agaaactgga aataaccttc cagtctaatc tatcttcgtt ttattttttc ttaggtgaat   990000
ggatggccat tcctagaaca tctgcaaacg cttcgtacat cacttcagag taagttgggt   990060
gcccgtggat ggtcttcagc atttcctcaa cagtgatttc catttcgatg atgcttgatg   990120
cttcgtttat taattctgcg gctgcaggac caataatgtg tacaccaagg atttctccgt   990180
atttcttatc agcgataact tttacgaaac cttgagctgc gtcagatgca atagcacgac   990240
cgttagcagc aaagttaaac ttaccgatgg caacatcgta tttctcacgg gcttgttctt   990300
ctgtcaaacc tactgctgct acttcaggga gagtgtagat ggctgcagga gtcaaattca   990360
atttggcaac tgcatgattt cctttaaggg cattttcagc ggaaacttca cccatgcgga   990420
aagctgcgtg agccaacatc ttagtaccgt tgatgtcacc tggtgcataa atgcctggaa   990480
ctgaagtttc catgtattcg ttgaccttga tacaaccacg atccaattca aactcaacct   990540
ctccaatacc ttcaaggtct ggcatacgac caattgaaag aagagctttg cttgcgatga   990600
tatcgtcttt tccttcaacc ttgatacgaa gttgaccatt ttcctcaatg atttcttgca   990660
gtttagtacc agtcaagatg gtcattcctt tacgctcaag aatcaagcga aggttcttag   990720
aaacttccac atccatagct ggaactatac ggtccatcat ttcgataaca gtcacttttg   990780
aaccaaatgt catgaaggcc tgaccgagtt cgataccgac aactccacca ccgatgataa   990840
caaggctttc tggcacttcg ttcatttcaa gaatgtcatc actagtcatg acaagtggag   990900
attccatacc agggacgttg atcttgttga cttttgaacc accagcaaga atgattttct   990960
tggtttcaag caattcagaa ccatttacca agacgttctt gtctttagtg attgtaccaa   991020
ttcctttatg aacagtaact ccgtagctac gaagaagtcc tgcaacacca ccaacaagag   991080
tattaacaac tttagattta gtttctaaaa gtttttccat atcaacagtg aagttaggat   991140
tttcaatcac gataccacga tttgcagcat gaccgatatt ttcaataatt tcagcgttat   991200
gaaggtaggt cttggttgga atacatccac ggtttaagca ggttccacca agttcagatt   991260
tctcaacaag ggcaacctta ccgccgaatt gggcagcttt aatggctgca acataaccag   991320
caggacctcc accaatcaca acgatatcaa aagcatcatc gctcttacca tcatcgtttg   991380
aggtacttgc tacaggtaca gggctagctt ctggcgatgc tgctccagct gttgggatgt   991440
tttccctttc ttcaccaagg taaccgataa cttccgttac agggacagtt tcaccatctc   991500
ctttgagaat ggcaatcaag tacccatctt cttcggcttc caattccatg ctgactttat   991560
cagtcatgat ttccaaaagg atttctcctt cttttacaaa ttctccgact tttttattcc   991620
attggacgat ttgtccttct gtcatatcca cgccggcttt tggcataatt acttctaagg   991680
ccatgtcttc cttcctttat ctatatctta aaaatgaata ctcttgctct taaattaaca   991740
ttgagattgg cgtttcaatc aactctttca agtccttcat aaacttagca ccagccatac   991800
catctacgac acggtggtca atggttaatc ctaaactcat gattgggcga atcacaattt   991860
caccattgac gacaactggc ttctcgattg tcgaactgac accaaggata gctgagttgg   991920
gttggttaat aatcggacca aaggactgaa caccaaacat tcccaaatta ctgattgtga   991980
atgttgaatt ttgtaactca cttggagcca atttaccatc caaggtacgg ccaataacat   992040
ccttaaaggc tacaaccagt tctgaaagac tcatcttctc agcattgtaa acaacaggtg   992100
tcatcaatcc attatccatc ccaactgcca tggcaagatt gacatagttg tgagtgataa   992160
tagtcttgcc atcttctgtc aatgaagcgt tgatgtatgg gtgtttcata agagtcttaa   992220
caactgcaag cgaaagaagg tctgttacag tagtcttctt cccagttgct tccatgattg   992280
gctcaagaac cttcttacga agagccaaca tttcagtcat atcaacttca tagttgaggg   992340
tgaaggttgg cgcagtcaag taagattcaa ccatgcgttg ggcaataacc ttacgcattg   992400
gtgtcattgg aatacgctcg attttaccat atggtgttac gttatcaggg acttcttcca   992460
ctttttcaat ctgagcagga gatttgatgc tatcgttttc gatattttca ggaagcaggg   992520
ccaaaacatc cttcttcatg attttaccac gatgaccggt tccttggatt tcctgccaag   992580
caatgttatg ttcgagggca attcgttttg caagtggcga aatgcgaacc acgtttgtgt   992640
ctttataagt ttccacgtct tctttgtgga cacgaccgtt tgcacctgag ccagaaacgt   992700
cgtagaggtt tatccctaaa tcatccgcta actttctagc tgcaggagtc gctcttagct   992760
tgtcatcagc catgacctct ccaattctat ttatgataca aagggcgtca aaagcgactg   992820
aaaaatagga aatcgacgat ggcttcgatg aagccaagga gatttatctt ttttccgatc   992880
ttttagcccg tgctctaatc taagatatta atgacgaaga gctctgcacc taaaagatac   992940
aaagtttctc gtcagcttta ttttatttac ataacttatc ttatgtaacc ctattctttg   993000
ttataagttt ttcggattgc atctttgata ctttcaactg ttggaatcat tgcattttct   993060
aggttttgtg cataaggcat cggcacatct tctcctgcac aacggcgaat tggtgcatct   993120
agatagtcaa atgcttctga ttctgaaata atagctgaaa tttcaccgat atagccactt   993180
gttttgtggg catcgttgac cagaacaacc ttaccagtct tcttcactga gtttatgatg   993240
atatccttat caagcggaac aagggtacgt gggtcaacaa tttcaactga aattccttct   993300
tctgctaatt cttcagcagc ttgaaccaca cggcgaagca tttttccata agtaacaact   993360
gttacatccg ttccttggcg tttgatttca ccaaccccaa gtggaattgt gtagtctgga   993420
tcaactggca cttccccttt ttggttaaat tctgacttgt actcaagtat aataactggg   993480
ttgttatcac ggatagaaga cttaagcagg cctttcatgt ccgcaggtgt tccaggtgcc   993540
acaaccttaa gtcctggaat gtgagtaaac caagactcta gagattgtga gtgctgggcg   993600
gcagagccaa ctccgttacc agctgcacaa cgaacagtca ttggaacctg acctttacca   993660
ccaaacatgt aacgtgtttt agcagcttgg ttgacgatat tgtccatggc aataacagag   993720
aagtccatga aggtcatatc gacgattgga cgaagtcctg tcatggctgc tcctgctgct   993780
gctccagaga tggcagcttc agaaatcgga cagtcacgga cacgttctgg accaaattct   993840
tcaagcattc caacagaagt accgaagtct cctccgaaga caccgacgtc ttctcccatc   993900
aagaacacat tttcatcgcg acgcatttcc tcagacatag caaggataat ggtgtcacgg   993960
aaggacattg tttttgtttc cattttatct ctttctcctt agtctgcgta aatatcttca   994020
aaggctgatt caagcggtgg gaatgggctt tcctctgcaa atttaacaga agcttctact   994080
gcttccttta cttgcgcttg gatttcttcc aattcttcgg cacttgcaat gttattttca   994140
ataaggtaat tgcggaggtt ttcgattgga tctttttgtt tccacaattc cacttcttca   994200
cgcgtacgat atttaccagg gtcagatgat gagtgaccga gccagcgata agttacactt   994260
tcaatcaaga ctggaccatt gccactgcga acatggtcca cagctttctg aaatccttca   994320
tagacatcga tgacattgtt accgtcttcg atgaacattc caggaattcc ataagcggcg   994380
ctacgttgat ggatatgttc tatattggtc attttcttga tatccgcaga gataccgtaa   994440
ccgttgttaa tgcaatagaa aatgactggc aggttccaga tagaagccat gttcactgct   994500
tcgtggaaaa caccttcatt ggtcgcacca tctccaaaga agcagacaac gattttaccg   994560
gtattttgca tttgctgact gagggctgca ccgacagcga tccccatacc accacctacg   994620
ataccattgg caccaaggtt cccagcatca aggtcagcga tatgcataga tccacctttc   994680
cctttacagg ttccagtgta tttaccaagg atttcagcca tcattccgtt gaggtcaatc   994740
cctttagcaa tagcttgccc gtgtccacgg tggtttgagg taatcagatc atctggattg   994800
agagctaaca tagcccccac gttagctgcc tcttcaccaa cagaaaagtg cgtcattcct   994860
ggcactttcc ctttctttac taattgtgca atttttaagt ccatgcgacg gatttcttcc   994920
atcttacgga acatttctag caaaagattt ttatctaaag ttgacatctt cttgcctttc   994980
taactttctt cttaccttac tattttaccg cttttggcaa atactgtcaa agtttttcta   995040
aaagaaattt cacaaaataa aaaagaaaac cccgtgaaaa caagggattt tcttgtcaag   995100
aatatttttt cacaaacttt ttagcatttg gattttgcta aagattcaaa tctcttcata   995160
atcacagtta aacgccaacg gtagagcgcc ccgctcacaa tcaaactaat aatcaagccg   995220
atccagtaag aataagctcc aaaatctgtt agggaatcaa atagcgtacg cacagggatt   995280
gctacgcccc aataaccaag caaaccaagg taaaaaggaa taactgtatc cttatacccc   995340
cgcaaaattc cctgaagcgg cgccgcaaag gtatctgcta actggaagaa aagactataa   995400
gttaaaaaac gcactgtcaa atcgataaat tttgggtcgt taccataaag actggccaca   995460
tttcccctaa aaatgtaaag gaaggttaag gtgaaggccg caaaaatgag ggcagtccat   995520
cttcctagac caatataggt tttcgcatca tcaaatcgct tggctcccac ttcataggaa   995580
acgacaatag ccatagccga tgagatactc ataggaaagg cgtacataag acttgaaaag   995640
ttcatagctg actggtgact agctataatc aagggcgaaa acttagccat aatcaagcca   995700
accactgaaa agatagccac ttccgcgaag acagttcccc caataggcag acctaaacga   995760
actccttcct taattttatc catattaagt ggaattcgtt tctcaaggtg taaggctttg   995820
agcttctcct gtttaaataa aaccagaaca gaaatcccaa gcaagaccca gtaggccaag   995880
gatgttccta aaccagcacc agcccctccc agttctggaa caccaaaggc accgtaaatc   995940
aagagatagt taaatccgct attgagaggg agtaacaaaa gcatgaggta catggacagt   996000
ttggtcaagc ccagcgaatc cagcaaggaa cgaatgacgc taaagagcaa caaggggata   996060
atcccgatag ataaaaacca aagatagcga accgctactg ccgctactgc tgcttctaac   996120
ccaatatgat tcaagattat tggtgccaag aaaagtacca tccccagcaa gaccacagat   996180
aggcccaagg ccaaataaat aaattggtaa aaatcagacg caacttcttc ctttttgcct   996240
cgaccaagat ggtgaccaat gataggcacc aaggctgaca caatccctgt tagaaatgta   996300
aagaaaggat tccagatact ggttgccata gatacaccag ccaagtccat agtgttgtat   996360
tgacctgtca ttgcagtatc aacaaaagag gcagaataat tggcaaattg gtagatcagg   996420
attgggaaga aaatttttaa aaataatact aacttctctc gtaaacactt tgtcttatac   996480
atacttctct ttctattctg atttatctaa accaaagagt ttcagaccat agtttttcaa   996540
acttagcgga ggtttattag attttgaagt agtatgccaa cacgcacatg tacgacaata   996600
atagcttcta actaaacctc cgttatcata ttgaaccgca tggtcagctt tttctttagt   996660
ttcatattga attttggaac gattagctgc gggacagtaa attccactat tagatttcgc   996720
ttgtctctcc ctacgttttc gaaaataatt catattctaa ctcctatcaa gcttgataga   996780
cgatttgtcc cttacagatg gtatatttaa cctgcccttt taaggtttca ccgatgaatg   996840
gtgaattagc tgctttggaa gcaaaatggg agtccacaaa gcggtcagcc ttggcatcaa   996900
aaatagtgat atctgctgga ccattctcag ccaagtaacc tgcttcaaag ttgtaaagct   996960
tggctgggtt gtatgtcatt ttttcaagta attccatcaa gctcaactca ccagcttcta   997020
ctaaataggt caagctgaga gacagggatg tttctaagcc agtcatacca gatggcgctt   997080
tggtaatatc ctcaacattt ttttcatcta catgatgagg cgcgtggtca gtcgcaataa   997140
ctgtgatgac acctgatttg agaccttcga taacggcacg acggtctgat tccaaacgaa   997200
gcggtggatt catcttagca ttgctacctt gtgttaaaag aagtgcttct gtcttagaga   997260
aatgctgtgg cgctacttct gctgtgactt ctgcacctaa cccctgagca aactccacta   997320
ctttaacact ttcttcctta gacaaatgct ggatgtgaac atgggcttta gttgcatagg   997380
caatcatgac atcacgcgcc atcatagcgt actcagccac cccagtagca ccgcagatat   997440
ggaaatgttc tctagcaata ttttcattaa agccaagaac accgttcaaa cctggatctt   997500
cctcatgaag gctgataaag gtattgagtt ttttggcttc ctccatggct tccttgacaa   997560
tcttactgct ctcaagcgga ataccgtcat cagagaaacc aaccgcacca gcttctaaga   997620
gtgccttaaa gtcagtcaag tttttaccat taaagttttt agtaatggtc gcaactgtct   997680
tgacattaat cttctctttg gcagctgact ggagaactgc ttgcaaagtc tccacgtctg   997740
aaatggttgg actggtatta gccatcatga cgacagtagt aaaaccacct gcagcggctg   997800
ctagggcacc agtatgaatg tcttctttat gtgtttgacc aggttcacgg aaatgaacat   997860
gaatatcgac caagccagga gcaaccacaa gaccagtagc atcaatcgtt tctgctcctt   997920
cttccgtgat ctcagacgca attttgataa ttttcccatc ttgaactaag acatcacaaa   997980
cttgatccaa accagacttg ggatccatta cacgaccatt tttgattagt agcatctgct   998040
ttctccttta ttcatagaaa tcaacttggg tatccaacaa tttatcccca tcataaacaa   998100
acttggctga aaagaagggt ttatcctcta aaagccactc aacaaaggtg tggtcacctt   998160
cccaagtcgg cttgctcaaa acctcatcat agggaaccca ttctagcgtc ccctcattgc   998220
agtcaatcaa gtcgccctca aactccgtca ccttaaaaac ataggtgtac cagtctaaat   998280
ctggtgtaaa ttcaggaaaa gtgatgacac cttttagaac tggcttggct ttgagccctg   998340
tttcttcaag gatttcacgc gccgcgcatt cctggggcgt ctctcctctc tctagcttac   998400
cacccacacc aatccatttc ccttcatgga catcattggg tttcttatta cgatggagca   998460
tgagcagttc tttcccatta tcaatgtagc aaatcgtcgc taactgaggc atattttctc   998520
cttatctaag ccaatcgatt ggctcttgtc ctgtctcttt taagaatgca ttggccttgg   998580
aaaagggctt ggaaccccaa aatcctctat aaaccgacaa aggacttgga tgggctgatt   998640
cgataatcaa gtgatgagga ttggtaacta atgccttctt cttacgtgca taagctcccc   998700
agagtacaaa aacgactggt ctatctagat gattgaccac ctgaatcaca gcatcagtaa   998760
aaggctccca gatttgacca gcatgaccat tggcctgtcc agcaggaaca gtcaaacaag   998820
cattaagaag caagactcct tgctcagccc aagctgtcaa atcatgagat ttcttaactc   998880
cgatatcatc tgacaattct ttcaagatat tttgcaagga tggtggagct gggatagagt   998940
caggtacaga aaaactcaag ccctgcgctt gacctggtcc gtgatagggg tcttgcccta   999000
gaattaccac cttaacttct tcaagcagtg ttgtcaagag agcctgaaaa accttttcct   999060
tgggtggata aataatcccc tgagaataga cctgctccat aaactgattg attttcccga   999120
aataaccctc aggtaattgc gccttaatca aagcatgcca agacgagtgt tccatagccg   999180
actccttcat ttttactgcc tctattatag caaaaagtgg ctatggaaac cactttttac   999240
agtttatcta aagatttaat aaatcgacta tatatacgat ttgaatacgt gaatacagtt   999300
tataaagact ggctattttt tataattact ttttaaatca ttaagcattt tactacctct   999360
ttcgaagatt atcttttctg aaatattttt aaacatatta aaatccatct cagaaaaagg   999420
agtttcttta gaaacttgcc atatagtctt taaataattt ttttctaaaa agtcgtcaaa   999480
attagaaaaa aatcgaaaat acaatgcatt ctcttggtgt aaaatcgctc tttttaaagg   999540
ataatactct ttaatattat taactttttg ttcgtaggca tattttgcta catgatctag   999600
gtatatatca aaaaagtcat gaggaaaatc tcccatacag ccattacgat tcatattgag   999660
gctatatttt cgattagtaa gataattcgg aaatatattt cctattactc taagattatc   999720
tacttgtgaa tcccttctcc caatataatc cccttctttg actaatgatg gagatttcca   999780
agtaaaaatt aaatcgccag agaaattttt cttatcaaaa aacttaaaaa gagattgata   999840
aatactattt gctaattgac aagtgtcaga tgtaaattca taattaacag cttcattaaa   999900
atcaacttca gacatttcaa tgtactcttc aatagtaata ttagcttttt tgtagtcatt   999960
agctcgtctc ctttaaaatg tgatcttttc aagaatattt ttatctaaac aatccagcaa   1000020
gtcttggtaa gaatagactt cgtaagtcgg ctgggcttgt gtgtgatttt cgaggtgatg   1000080
aggattatac cagatagtgt caatccccgc attattgcca ccttgaatgt cggcggttag   1000140
agaatctcca atcatcagcg tcttttcttt actaaatcca gcaatttgct ggccaatctt   1000200
ttcataaaaa agagcatccg gcttttgagt ttgcaactgt tctgagataa agacttgatt   1000260
gaaataaggt gctagaccag attgagccaa acgtcctgtc tgaatggcag taatgccatt   1000320
tgtcgcagca tacaagttat aatcacgctc aatgaggctg tccaagagat catgagcgcc   1000380
cgatagtgtt tgtccctgct gggcgaggta aaattggtaa cgctgggcaa gaaaactacc   1000440
gtctttttcc tgtccaaaat gagcaaataa acgagaaaag cgcgtgttaa ccagctcttg   1000500
tttactgatt ttcttcagct ccaagtcttt ccagagagcc ttgttcatag gaacgtaata   1000560
atctttataa gcctgaatat ccgcaactcc ttcttctttt agaagttggg tcaaagccac   1000620
atcctcagca gcatcaaaat caagaagagt gtggtcgagg tcgaagagta gaaatttgta   1000680
gaacaatttg aggttttcct ttctgaaaat tcattaagaa cattatatca taaagcacct   1000740
catacaatta actaatttaa tcacttaaaa aaattcgaac actttctata caactgacag   1000800
ctcaaatctt tcagaataga acaatactaa ctatcgaaca ccccgtcttc ataaatatat   1000860
atatgtaatt ctagacctag aattcctata aactaaatgc tttcatactc ttccaagtaa   1000920
ttgattgcct taaattttaa tttttgaagg tttctaaagc tagaatagcc ccatcacaat   1000980
cagttttgat tgattcacaa tttagaaaca ctatagtttc actcctgtta aaataaaaag   1001040
gaactgcata aagcaatccc tttctgattt tgaaatcatt tacttaacat tttatagttg   1001100
agataatcaa tagcttatct ataaaaagag ttatagtaaa attccttatt tattgatttc   1001160
aagctccgct aactgtgttt gaataactga cagttctgca ccagcctgaa gaagagcagc   1001220
tgcattatag gcaccttcta caattggaac cctgttgatg atgatacttt tatcactgaa   1001280
atcagtcacc atttttaagt tcattttagc agaacctagg tcaaaaaagg caagtaaagt   1001340
atctgctgga ttttcggaaa caaccctatc tacttgttca aaactcgttc caattcctcc   1001400
gccctcggtt cctcttacat aagtaatcgg aacatcttta gctactttac taatcagttc   1001460
aacaacacct tctgcaatgt gtttggaatg tgaaacgata acaagaccaa tactttccat   1001520
caaaccaccc cagtttctaa aatagcagta aagagtaatc ctgatgagaa tgatccagga   1001580
tcaatatgtc caagaaacca catgctccta agacaagagc taacagactg gccatcaata   1001640
atagtattgt tctttttttc atcattactc cttaactagt gtttaactga ttaattagcc   1001700
agtaaatagt ttatctttat ttacactatc tgttaagata tagtaaaatg aaataagaac   1001760
aggacagtca aatcgatttc taacaatgtt ttagaagtag aggtatacta ttctagtttc   1001820
aatctactat attttgcaca ttttcatgaa aaaaatgaga actagaactc acattctgct   1001880
ctcatttttc gttttcccgt tctcctatcc tgtttttagg agttagaaaa tgctgctacc   1001940
tttacttact ctcctttaat aaagccaata gtttttcagc ttctgccata atagtattgt   1002000
tgtcctgggt gccaaatagt aaattatttt ttaatcctgt gagagtctct ttggcattgg   1002060
acttgataat tggatcctgg atttttccaa gtaaatcttc agcctctctc agtttttctt   1002120
caaccttttc agtctcgacc tgaggttctt ctgattcctc tggtgattct tctggttcct   1002180
ctgttggttt tggagactct ggtttctcgc tttgcggttt ctcttctcga ggggtttctt   1002240
cctcaggttt ttctgtctga ggtttctcct cgcttggttt ttccgtttga ttggtatcag   1002300
cttgaccatt tttgtttctt tgaacatggt cgctagcgtt accaaaacca ttatctgaat   1002360
gcggacgttc gtttggatgt tcgacatagt acttgacagt cgccaaaaga tcctcaagag   1002420
tatacccctt aggtgcctca taaaggcctt cgtcaaacca ctcaaatttg atgttatggt   1002480
aatggtcata atgaggtatg attaaactac cgtttttgac ttctacagta tattgaagat   1002540
tgtaaggcat acgatcaagt ggcaccttct tagctgcttt cacgcggttg tagatagctt   1002600
ctgctccttt tgcctcagta tttcctgaat cctgatggtc tgtcgaagga ggggtcaaac   1002660
ctttctcttt agcataagcc tgggctgccg ctctctcagc ttcagacaaa ctatcttttt   1002720
taatccagtg gctatgggtc atatgtggag ttacataggc atccccctca tcactggtta   1002780
tatcacgagg atcaaagata taaccgtctt ctgttgtgta cttgcctgcc aacttggcta   1002840
cttgaatctc atcatcagtg taggtaattt gcgcatttgg ttttcctaaa cgttctggat   1002900
gacgaatcgg agctaagaag gcaagaatat cttccactaa cttgacttta tcacttgaga   1002960
catccttgag tcgttccaac aggttatcca aagcctcaaa atcaacttgt cgacctttat   1003020
tatcaagtaa atcttggtga attcttgcta gtaagtcata agccttattg taaaattctc   1003080
gatcactaga tgggaggtca gttttcttag ttcctagctt atgagataaa ctttcctgct   1003140
tggccagttt gctatcaatg cctgctgctg tttctgctga aagatccttg gctgggatat   1003200
aacgagaaac tccattctcc tcaaagacat aaccatcgcc tacttttcga acagcttctt   1003260
tgaccaattt ctcatcaatt ggattgcttg gagctggttg cggacttgga ctaggttctg   1003320
gagtcggttg tggacttggt tcttctggtc ttgaatctgg tacccaatgg tttgaacgat   1003380
aacgaagggg aataatacga gcaattcgtt tttccaattc agacatttgt tcataaggga   1003440
taaagtggta atggttacca tgagggacag ctacacctct ggcggttcga cttgtgattt   1003500
gcgctgggtc gaaaataagg ccatcagatt ccacatggcg ttctgataag ggtttagcat   1003560
acaattcacg taaaaggctt gaaatgtttt ccccttgatt ttgatgataa gttggagtga   1003620
cagtcagatt gtggttctct gacaatcttg gttgagctgg atttgcatta taactagaac   1003680
ttgaagaagg acgagatccc tgcttcccat tccaataggc ttctgcagca gctaactcgc   1003740
tagctgataa ctcattctta ggaatgtaat ggtaatggtc gccgtgagga acgatataag   1003800
catcacccgt gtcctcaatg atatcagatg cattgaagat atacccatca tccgttgtat   1003860
aacgtccttg ggctctggct gcagcaacag cattatctgc tcttgagtta tgattatgac   1003920
tgcgttcctg cttctgacgt ttaatctctt cttttgtccg aatattatcc gcatgagctg   1003980
catccttaag gtaaacatag tatttaccgt ttaccttaat gacataacca cccttgattt   1004040
cattgacaat gtctgaatcc ttcaactgat aattcggatc tttcatgagg agctcttcac   1004100
tgatgatggc atcataagga accttgccat tatagtaatg ataatggtct ccatgagagg   1004160
tcacataacc ttgatccgta atcttgataa caatttgttc ggcgttgatc ccctccctct   1004220
tactgacttc atctggtgtc aagttttctg ccttttgacc agcctgatca ccatctatat   1004280
aagcaactcg attagactct ttcttatcct gaccagcttg gtaacgtcca agctcatagg   1004340
aacaaacact tagggcaagg actgccactg aacctgctag atatttttta ttaattttca   1004400
ttctttcctc ttttcttaag tatatttgat tcactataaa gtaataaacc ggttaattaa   1004460
ctagttaata gtttactctt tttaatattg cttgtcaaga attttacata tatacataat   1004520
aaaaatgaaa gcctctttat cgagactttc atttttcatt agtttatttt ttccttactt   1004580
acagatgaag gattacttcc ttttaacaac gcaagtaatt tttctgcttc tgccatgata   1004640
ctattgttat ccataatttg aagagtcaaa ttatttcgta aaccagctag agtttctgtt   1004700
gcattggctt tcagactaga atccgttact ttcgcaagca aaacttctgc ttctttgagt   1004760
tgggcttcta ctttttcagt ctctacttga gggacttctg gctcagcagg tgtttcctct   1004820
actggctctt catccgcttt gaagttctta tttggatctt cactgtggtc tttcttgcct   1004880
aacacatgct cactggcatt gccccatcca tcattagaat gtggacgttc gtcagggtgt   1004940
tctacgtagt acttaatcgt cgcaaacaaa tcttccaagg tatagccatt tggagctttg   1005000
tatgtgtgat catcaaacca agcaaattta atattatggt aatgatcctt atgaggaata   1005060
atcaaattac cgtttttaac ctcaactgta tgctcaacca tatatggaag tcgaacgagt   1005120
ggaattcgtt tttccccttt cacacgattg taaatagctg ctgcactatc tccagttgga   1005180
tttgctttaa catctgcgtc tggagatgga ggtaggatac ctttttcttt agtataggct   1005240
tgagctgcaa ctttttcctt atcagaaagg ctatcttttc caatccagtg actatggccc   1005300
atatgaggcg ttacatatgc atctccttca tcactgatta tatcatgttc atcaaaaatg   1005360
taaccatctg acgttgtata cttatcagct aattgagcaa tacgaacttc gtcttcagta   1005420
tactcaattt gagaatttgg tttgccaagt cgctctggat gggtaattgg tgctaggaat   1005480
gccaataaat catctaccaa tttttcttta ttagtcgatt catcattcaa gcgttctaat   1005540
aatttgtcta aggcttggaa atcagaatta cgacccttat tttcaaacaa ggctttatga   1005600
gcctcagtta acagattata tgctttatca taaaattctt ggtcacgagg agcaacattt   1005660
tcttttttag cagttaaagt gtgtgaaaca ctctcttgtt ttgataactt gctttcaaga   1005720
tttttaacag tttcagatgg taaatctttc gcaaagacat aacgagagat gcccttttct   1005780
tcgaatacat atccttcccc aacttttcgt accagctgac taaccaaaga agaatttgag   1005840
tctattttaa gatttggtgc aggttgcggg cctggactag gttccggagt cggttgtgga   1005900
cttggttgtt ctggccttga atctggtacc caatggtttg aacgataacg aaggggaata   1005960
atacgagcga ttcgttcttc caattcagac atttgagagt aagggatgaa gtggtaatga   1006020
tctccgtgtg gcactgcaac acctctagct gttcgacttg tgatttgtgc tggatcaaag   1006080
acaaggccat cagattctac atgtcgttga ctcaaaggca gtttgtagag ctgtttcaag   1006140
agactatcaa tgtcattact ttgacttgct tgactgttag tgttgctgtt gttgcttgtg   1006200
ttagtatttg tagttcctgg attgcttaca gaaggtaccc agtttgttct tgaagtgtta   1006260
tcgctatttt gtcggcgata ggttcttgaa tttgacagat ttcctcgacc agataggaag   1006320
gcttctgcag cagccaactc gctagctgat aactcattct taggaatgta atggtaatga   1006380
tctccatgag gaacgatata agcatcacca gtatcctcta tgatatcaga agcattaaag   1006440
atataaccat catctgtagt atagcgtcct tgcgaacgtg ccaaggcaac agcaccatcg   1006500
tttcttggag ttccaccttc acgatgttga ctatgctctt gtttttgtcg attgatttcc   1006560
tcttttgtac ggacgttatc cgcgtgggca gcatccttaa ggtaaacata gtattttcca   1006620
tctaccttga taacatatcc acccttgacc tcattaacaa tatcctcatc ttttagctta   1006680
tagtttggat ctttcatgag taattcttca ctgatgatag cgtcataagg aaccttacca   1006740
ttgtaataat gatagtggtc gccatgtgaa gtgacatagc cttggtctgt tatcttgatg   1006800
acgatttgct cagcattgat tccttcacgc ttgctaacct catcaggagt caaattctcc   1006860
gttttttgcg tcgcttgttt tccatctata taggaaacac gattattttc cttaaccgtt   1006920
ctagcttgat acagtcccaa ctcgtaagaa caaacactta aaatcaaagt gccgcagaac   1006980
caacaaggta tttcttatta attttcatcg aaactctctt tctatttgat atttctagtt   1007040
gcaattcatt tctaaattgc agaaactcct ctctattact taactggtta atagtttact   1007100
cctaaatatc caacttgtca agaattttat gaaccattta agtatttttt gttctgacca   1007160
ctactttttc aaggttggac tttctataag aaagattttc ttgaaaattc tttttaaaat   1007220
atcaaaaaaa tccctgtaac tgagttgcag ggacttttcg attaatcaaa attaacgtat   1007280
tctttttgaa gttcaagaac ttcttccatt gttgagcatt ctgtaagggc acggtttgcg   1007340
tactcttcca tcttagctgt gtcgagtttc ttcatcaagc tgcgtgtacg aagtacagat   1007400
gttgctgaca tagagaactc atccaagccc attccgacaa gaagtggaac agcttgttgg   1007460
tcaccagcca tctcaccaca cataccagcc catttacctt cagcgtgagc tgctttgatc   1007520
acattgttaa tcaagcgtag gattgatggg ttgtatggtt ggtaaaggta tgaaacttgt   1007580
tcgttcatac ggtctgctgc cattgtatat tggatcaagt cgtttgtacc aattgagaag   1007640
aagtcaactt ctttagcaaa ttggtctgca agcatagccg ctgcaggaat ctcgatcatg   1007700
ataccaactt ggatgttatc cgcaactgca acaccttcag caagaaggtt tgctttttct   1007760
tcatcaaaga ctgctttcgc tgcacggaat tctttcaaga gcgcaaccat tgggaacatg   1007820
atacgcaatt gaccgtgaac agacgcacga agaagagcac ggatttgtgt gcggaacata   1007880
gcatctccag tctcagagat agagatacga agagcacgga atccaaggaa tgggttcatt   1007940
tcgtgaggca tatcgaagta aggaagttcc ttatctccac cgatatccat tgtacgaacg   1008000
acaacaggtt taccgttcat tccttcaaga acagccttgt atgcttcata ctgctcatct   1008060
tcagttggga agtcttgaga atccatgtac aagaactctg tacggtaaag tccaacagct   1008120
tctgcaccgt tgttgttaac accttcaacg tcttttggag taccgatatt agcagccaac   1008180
tcgaagtgtt taccgtcagc agtcactgtt tgagcatctt tcaaaagtgc ccattcagct   1008240
ttttgtttcg cataggcttc accagctgct ttaaattctg ccgcttgttc atctgttggg   1008300
ttgataatca cttctccagt gatcccgtta acagcaagga tgtcaccgtc tttaacgatt   1008360
tcagtgatgt tatttgtacc taatacagca gcaatttcaa gtgtacgtgc catgatagct   1008420
gagtggcttg tacgtccacc aatgttggtt acaaaagctt ttacaaagtt tttgtccaat   1008480
tgagctgtat ctgaaggagt caagtcatgc gcaatcacaa tcacttcttc attgatagaa   1008540
gctgggtttg gcaatttttt accaagaagg tttgccaata cacgttttgt cacgtcgcgg   1008600
atatcgctgc gcgttcttgc atgtatgggt tgtcttccat gccttcaaag atagtgataa   1008660
acatatctgt aacttctttc agacctgctt ctgcattcac tttcttcgca cggatagttt   1008720
ccttgatttg gctgatcatt tctgggtcag caagaaccat taagtgagca tcaaaaactt   1008780
gagctgcttc ttcaccgagc gtacctactg ctttctcgcg aataacagaa agctcgtctt   1008840
gtgatgcctg tagagcggca tcaaggcgag cttcttctgc gtttgtatct tcgactgtaa   1008900
tagtctcaaa tgacaaatcc ggctgaacga gtagatatgc ttttgcaact gcaacaccgt   1008960
cagatgctgc gattccttta agcatttctg tcatttccct tatgccaatc cttctttttc   1009020
cattgtttct gagattgcag cgatagcgtc atctgcatct gcaccttcag ctgagatagt   1009080
tacgtcagca ccttggccaa caccaagact cataacaccc ataattgatt taaggttaac   1009140
tgatttacct ttgtactcaa gagtgatatc tgaagcaaat ttgctagcag tttgtaccaa   1009200
caatgttgct ggacgtgcgt gaatacctgt ttctgccact acgtggaaat ctttagaagc   1009260
catagtttga ctctcctttt gttctttctt tttttgagtt atatgtgata acccttacaa   1009320
tttagtatta taccatcttc taggattttt ttcaagcatt ttctggattt tccttcaatt   1009380
tcctttcaga taacttgctg aaaatcttct atcctagata acaaaacaca ggatatagtt   1009440
tctttaaaaa caatttatag gataatcatt gctatttcac aatacaaaca ctatatattg   1009500
tgtttatata taaaaacaac aaaagaacac cactatattt agttcaaatc attgacaaaa   1009560
ttttattttc tgatatacta agatagtatt aaattttgaa gaggagttac acaatggtaa   1009620
ccgtttattc taaaaacaat tgtgtccaat gtaaaatgac caagcgtttc ttggacagta   1009680
ataatgtctc ttatcgtgaa atcaatcttg atgagcaacc tgagtacgtc gatcaagtta   1009740
aagagctcgg ttttagcgca gctcctgtta tccaaacacc aactgaagtc ttttcaggtt   1009800
tccaaccagg aaaactgaaa caattagcat aatcttagta catcatccag aagaaactgc   1009860
ttttagggct aacttagaag cctttctttt gtaattagat aagggaaatt ttatgggatt   1009920
aaaacatctt gaagacgtga cttacttccg tcttaataac gaaattaacc gtcctgttaa   1009980
tggacaaatc atgcttcata aagacaagga agccttggat gctttcttta aagaaaatgt   1010040
agttccaaac actatggttt ttgattcaat caaagacaaa atcaattacc tcattgaaca   1010100
caactacatc gaaacagcct ttatcaagaa ataccgtcca gagttcttgg aagaattagc   1010160
tcaatttatc aaagaccaaa acttccaatt caagtcattc atggcagctt ataaatttta   1010220
caatcaatat gccttaaaga ctaatgacgg tgaatactat cttgaaaata tggaagaccg   1010280
tgtcttcttc aatgcccttt atttcgctga tgggaatgaa gctgttgcaa tcgatattgc   1010340
caatgaaatc atccaccaac gctaccaacc tgctactcct tccttcttga atgctggacg   1010400
tgctcgtcgt ggggagttgg tatcttgttt cctaatccaa gtgacggatg atatgaactc   1010460
tatcgggcgt tctatcaact cagctcttca actttcacgt attggtggtg gtgtgggaat   1010520
taccctcagc aaccttcgtg aagctggtgc acctatcaaa ggctatgaag gagctgcttc   1010580
aggtgtcgtt cctgttatga agctttttga agacagcttc tcttactcca accaattggg   1010640
gcaacgtcaa ggtgctggtg ttgtctacct caacgtcttt cacccagata tcatcgcttt   1010700
cctttcaact aagaaagaaa acgctgatga aaaagtacgt gtcaagactc tatcacttgg   1010760
tgttgtagta cctgataaat tctacgaatt ggctcgtaaa aatgaagaaa tgtacctctt   1010820
cagcccttac tctgtagaaa aagaatacgg tgtgccattc aattacatcg acattactga   1010880
aaaatacgat gaattggtcg caaatccaaa tattcgcaag acaaaaatca aggcgcggga   1010940
tttggaaact gaaatctcta aattgcaaca agagtctggc tatccttatg tagtcaacat   1011000
cgatacggct aaccgtgcaa atcctgttga tggaaagatt atcatgagta acttgtgttc   1011060
tgagattctt caagttcaag aaccaagctt gatcaacgat gctcaagaat tccttcaaat   1011120
gggaacagat gtttcatgta acctgggttc aaccaacgtg gttaacatga tgacttcacc   1011180
tgattttggt cgttctatcc gtgctatggt tcgtgccctt actttcgtta cagatagttc   1011240
acatatcgta gctgtaccaa cgattgacca tggaaatagc caagcccaca cctttggtct   1011300
cggtgccatg ggactgcaca gctaccttgc ccaacaactc attgaatatg gttcacctga   1011360
gtctgttgaa tttacaagca tctactttat gcttatgaac tactggacct tggtagagtc   1011420
aaacaatatt gcacgtgaac gtggtattac cttccacaac tttgaaaaat cagactatgc   1011480
taacggaagt tactttgaca agtatgtaac tggtgaattt gttccaacat cagaccgtgt   1011540
taaagaactc ttcaaaaatg tctttatccc tggtgttgct gattgggctg aacttcgcga   1011600
caaggttcaa gaagatggtc tttaccacca aaatcgcctt gctgtagcgc caaatggttc   1011660
tatcagctat atcaacgacg tttctgcttc tatccacccg attacgcaac gtatcgaaga   1011720
acgccaagag aagaaaattg gtaaaatcta ttaccctgct gctggcttgt ctacagaaac   1011780
cattccttac tacacttctg cctacgatat ggatatgcgt aaagtcatcg atgtttacgc   1011840
tgctgcgact gaacacgtgg atcaaggact ttcactcacc ctcttcatgc gcagtgacat   1011900
tccaaaaggc ctttacgaat ggaagaggga aaataaacaa acgacacgtg acttgtccat   1011960
ccttcgtaac tatgccttta acaagggaat caagtctatc tactacgtcc gtacctttac   1012020
agatgacggt ggagaagtcg gcgccaacca atgtgaaagc tgtgtgattt agtttctagc   1012080
atagaaacac tatttttccc taagcagcac tgataaaatc aaatctacta tgtcataaca   1012140
taatttatgt aacattttaa aagtcgggct tccgactttt tgtgcgatac tcctatagaa   1012200
ttatggtaaa gtagaaataa ttgtgagttc gcaatactaa acacagaaag agattttaaa   1012260
tggaaactta ctacaaagcc attaactgga atgccatcga agatgtcatc gacaaatcaa   1012320
cttgggaaaa actgacggag caattttggc tcgatacacg tattccctta tcaaacgact   1012380
tggatgactg gagaaagcta tctaacaaag agaaagactt ggtcggaaaa gtttttggtg   1012440
gtttaaccct tcttgacact atgcaatctg aaactggggt tcaagccctt cgcgcagaca   1012500
tccgtacacc acatgaggaa gctgtcttca ataacatcca atttatggaa tctgtccacg   1012560
ctaaatctta ctcatcaatc ttttctacct tgaatactaa ggctgagatt gaagaaattt   1012620
tcgaatggac caataccaat ccttacctac aaaagaaggc tgagattgtc aacgaaatct   1012680
acctaaacgg cagcccactt gaaaagaaag ttgccagcgt cttcctcgaa accttcctct   1012740
tctactctgg tttcttcact cccctctact atctcggtaa caacaaactt gccaacgttg   1012800
cagaaatcat taaattgatt attcgtgacg agtctgttca cggaacctac attggttaca   1012860
aattccaact tggtttcaat gaattacctg aagaagagca agaaaaactc aaagaatgga   1012920
tgtacgacct actctatact ctttatgaaa atgaagaagg ctacacagag agtctttatg   1012980
acggtgttgg ttggactgaa gaggttaaaa ccttccttcg ctacaatgcc aataaagctc   1013040
tcatgaacat gggacaagat ccacttttcc cagattcagc tgaagatgtc aacccaatcg   1013100
ttatgaacgg tatttcaaca ggaacttcca accatgactt cttctctcaa gtcggaaatg   1013160
gttaccttct tggcgaagtt gaagccatgc aagatgatga ctacaactac ggtttgcact   1013220
aatactcttc gaaaatcaaa ttcaaaccac gtcagcttcg ccttgccgta ctcaagtaca   1013280
gcctgcggct agcttcctag tttgctcttt gattttcatt gagtataatt ctccaccact   1013340
cttaaccatc aaaaagtaaa ctagaaacaa caaaataata acttaataaa aatatcgaaa   1013400
gttttgaaaa taaacctcga tatttttgtt tttgttttat tttgttgttt ttgtatttga   1013460
atgatgagct agtttatggt aagatagtag taggaaacga ggtgataata tgctcaaaca   1013520
agaaaaatta accaaaattt tagagatagt aaatagtaaa ggaaccataa cagttaaaca   1013580
gattatggac gaaatagccg tttcagatat gactgcaagg cgctatttac aggaattagc   1013640
tgataaagat ttgctgattc gtgtgcatgg tggagctgaa aaacttcgaa ccaactccct   1013700
tttgactaat gagcgatcaa atattgaaaa acaagccctc caaacggcag aaaaacaaga   1013760
aatagcccat tttgcaggca gtctagtaga agaaagagaa actattttca ttggaccagg   1013820
aacaacatta gagttttttg cgcgtgagtt gcctattgac aatatccgcg tcgtaaccaa   1013880
cagtctacct gtttttctga ttttaagcga acgaaaatta acagatttga ttttaatagg   1013940
tggaaattat cgcgatatta caggtgcttt tgttggtaca ttgaccctac aaaatctctc   1014000
taatctccaa ttttctaaag ctttcgttag ctgtaatggt attcaaaacg gagctctagc   1014060
tacttttagc gaggaagagg gagaggctca acgcatcgct ttaaataatt ctaataaaaa   1014120
atatttactc gcagatcata gcaagttcaa taagtttgat ttttatactt tttataatgt   1014180
atcaaatctt gatactattg tttcagattc taaactaagt gattcaatcc tttttaagct   1014240
atctaaacac attaaagtca tcaagcctta ataaactgaa agagcctggg taacaactca   1014300
atttcagaag aaaaaaagta aatcttccca caataaaacg catagtatca ggtgttgaaa   1014360
cacctgatac tatgcgtttt tctatatcaa agactttttg cccaattcct caaagctatg   1014420
cattgagaaa tctgcgactc gcttcctagt ttaaagttgc tctttgattt tcattgagta   1014480
taagcaacgt gattagataa gagttttaca gagtactaaa tataagattt aacttttttg   1014540
agaaattggt tacgattgtt gaaacggcat aaaatctgaa tcaaaggaga tagtatccca   1014600
ttcttcagga ttgataaaat ttaaaaatag atttttaaat tcttccagct catcatctga   1014660
atgacaaatc cattctttac cagtcgagac ataccatttt ccaagacttt tcaattcttc   1014720
actcgtcaaa cacggtattt gagagcattt ttcgaaattt ataatataaa ctttttttca   1014780
taaatagatt ggataaaatc tttgaacatc tttttgactc actaaaattc tatatctaat   1014840
gactaattct actagtctat aatctgagtt tccgctactt tcttgtacca gtgagctgat   1014900
ttcttaggat aacgttcttg agtttcaaaa tctacgtaga agagaccata acgtttctca   1014960
taaccgtttg accatgagaa gacatccatt aatgaccaaa tgaagtaacc ttttacatta   1015020
gctccatctg caatcgcatc agataaaacc tccaagtgtt gcttcacgta atcaatacga   1015080
ccatcatcgt aaacagtgtt atcaacgaac tcatctttat agccgagacc attttcagtg   1015140
atgtaaatct tcttgtagtt aggataatct ttcttcacac gcatgatttg gtcatacaaa   1015200
ccttgagggt agataatcca atcccaatcc gtgcgtggta catagtcagg agctacacga   1015260
cgaccaacac ctttgatttg atacttagag cttccttttt cacctttacc attatggata   1015320
atttcagttt ctccatcaaa ggcttccatc cagtcactca tatagtagtt gattcctagg   1015380
aaatcattca agtcttttgc agcttctaat gctgtaaaat cttcttcacg aagatccaaa   1015440
ctaccaccat tgactaataa gatatggttg acaccttcca tggtttcagc tgaatagcga   1015500
cctagataag ttgcgtctaa gatgaattta ttgtggatga tatcttccaa ctcagctgca   1015560
cgaacatctg ctggattttc aggatctaga ggatatttag ttggcagggc gtgaacaaca   1015620
ccaatttccc ctttatagcc tttctctttg tacaatttta ccgcgcgtgc atgagacacc   1015680
atcatattgt ggtgtgattg aaagactttg gcaaggtcgt actggatacc tggagggaat   1015740
ttcccaacca aatattgacc atcaccgatt ggtccaattt cattaaaggt tgtccaatag   1015800
tttacttctg gaaattcttc aaaacagaag gcagcgtagt ctacaaaatg ttcgatattt   1015860
tcacggttta agaagtctcc atttgagtgg agagcttctg gcgtgtcaaa gtgatgaaga   1015920
gttacaaaag gctcaacatg acgtttgtga cactctgcaa ataaattatg ataaaactca   1015980
acacctttag catttacttg gccgtaacca gtcgggaaaa tacgtgacca agcaatagaa   1016040
attcgaatac cattgacacc atactcttct gctagcttga ggtcaactgg atatcgattg   1016100
taaaaatcac tagctggttc ggcagtgtac cagtagttat cctcaagata tttatcccaa   1016160
gcaactggtc cttttccatc agtatgtgta gcaccttctg cttgataagc agctgttgcg   1016220
ccaccaaaaa taaagtcttt tggaagtgtt tttgtcattt ttttcaccta tttcttgatt   1016280
taaataaagt aaaagtgaga ggagaggagt cagtgagcca tccttctcca tctcacttct   1016340
tgtaccaagt caccgaattg tgacatgagg aggtaaaaac gatatctttt taccgacgaa   1016400
ttaataatag gaaattcgcc atagcgattt ccgtaacgat gggagactat ttcagagtct   1016460
ctagccttaa tcgaattgcg cttgtacgaa tgcaagagca ccttttccat cacgagttaa   1016520
tttgatgtat tgagcgcctt ctgttttcgc tagtttaata ccgagcttat ctgtttctgc   1016580
tttcatatct tcaaagtttg aagcaacttg aggggcaagg ataacaagat caaactctgg   1016640
taacatttca cggtgagcac catagccgcc tgctgctgct ttcacaggga cattgtattc   1016700
tgctgctgcc ttattcaaag catttgcaag gagaccactt gttcctccac ctgcacagag   1016760
aacgaggaca tttgtttctt cagtgatggt attttgtgct gcatcgacac ccgctttttc   1016820
aagaatagca tccgcttttg cagtgttgaa gtttgcagca actttttctt tcaattcatc   1016880
attagactta cctgaacgtt cttcttcaag aatttgttca tcatagacct taaggaatgg   1016940
atagtaaatg acaacgtcaa ccacgattag aagggcagca agaatgaatg atagcacttg   1017000
gaagttagtt ccaagaacta gacctagtgg agctggagtt gtccatggta gattagcagt   1017060
gaatgagttc attccaagag tttcaataaa gaatttgaaa atccatacgt ttgcaattgg   1017120
agcaaagata aatggaatga agaagattgg attcaaaaca agaggtgcac caaacaagat   1017180
tggttcattt acaccgaaga aggtaggaac tactgaagca cgtccgattg cacggttacg   1017240
tttcgatttt gtcaaccaca tgaacataaa tggaacgacc aatgtcgcac ctgtaccacc   1017300
catggtaacg ataaacattt gtgtaccaga agtaagaatc ttgtctgcat gcatcccttg   1017360
ttggagaagg ttcaagttaa cttcggcatt ggcataggta atagctgcga tagctggttc   1017420
aacgatagat ggaccatgaa tcccaacaaa ccagaagaag gcaaaggcac caaagataat   1017480
ggtaatacca aggtatccgt ctgctgctga gaagagtggt gcgaagaatt taccgattga   1017540
ttctgccaca ctagaaccaa caaaataacg tgctaataag tcaagagcat aaagagaaac   1017600
aacagataga gtgaatggaa tcacatcttt aaagacttgt gagatatttg gtggaacttc   1017660
gtcaggcata cgaatagtga cgttgttctt aacacaaacc ttatagatgg ctacagtaac   1017720
aaaggcagca aggaaggctg aaagcaaacc ttttgtcccc aagaatccag tagctagacc   1017780
actttcgata ggatcagctg ccaacatcaa caaaccaaca attgctgcca acaatgttga   1017840
catatacttg atttgattgg ttttttccat gctccggttt actgagtcag tcaatgactt   1017900
agctgttgta ccagctacca agagagccag aatacccata gaatagctat aaggtttcat   1017960
cagaaaggct acaacttcat cagaccattt aaagccccat gagtttggta caaaggcaat   1018020
caagataaag atacttgaga agagaataac aggcatacct gcaatgaaac catcacgaat   1018080
agcacgaaga tagatattac gagatagttt ttcaaagaaa ggctttcctt tctcgataaa   1018140
tgcaattagt ttattcatta ttgaactcct ctcttgtaga gttcaattaa atgatgcatc   1018200
aaatctttta acaagatagt tgtcattaag tggtcttggc catgcatcat ggttacacta   1018260
taagccaagt cctcacctga agcttcctta gtcaatagac ttgtttgcgc gtggtgagcc   1018320
tctgcaatac agctaccagc ttcctctacc agagcgtccg ctttttcaaa atcaccagct   1018380
tcagcagcct tcaaggcttc caatagtttt gaacgagcat cgccagcata ggctacgatt   1018440
tcaaaaccta acaatgttac ttcttctcta ttcatgatag aattctcctt atatagtttt   1018500
aaataaattt ttatgacaat aaacgttgga tatgtagaac tagataaact cgttcacttt   1018560
tatacaaatc aagacccgta tgttgcgtaa tcacatcata gatcttggaa ccaatctcga   1018620
aggcttttgg ataggattgt ttaatatgat cttccatatc cagaagtgat tggttatcat   1018680
ctctagatct gtctaaataa tccaagaaat aattcaaatg gatcataaag cgatcataga   1018740
aatggttatt ctttttagtt cgttgaattg catagtccgt taaaacttct tcaacattcc   1018800
tgagaatttc tttcctctta tcaatcgact ccacaagttc cacttcattt tcaccttcag   1018860
cattaatgaa atgataagca atccgaataa tttcgtcctc aggaaaatga tctgctagct   1018920
tctgacggta aatttcaaaa gcttcatttg cgatttgaaa agcgacagga tacttagcgg   1018980
aaatatctgg cagattacta tccttgtacc ttccttgagt tagagcttga taagaacagt   1019040
aaatatgatc tgtcaaggtt acatagagat actcttgaat cggataatga tatttctttg   1019100
atagcttatc aatgatttca taggtcactg tgataaaatc aagcggaaca tctttgagaa   1019160
gagccataaa gttttctctg gactcttcgg tcttcatccg aaagattttc tcaacctgat   1019220
tttcagcaat caaatccccc ttcttctttc cgaatgcaat tcccttacca attacaatca   1019280
cctcttctcc cttatcattt ctgacaagcg agacattgtg attcattgga tttagaattc   1019340
gatacatgtc aacctccttt tatatcttaa aggtatataa gtacaaaaaa tgaccacaaa   1019400
tgaactagaa aatcagctga tttctaattc acctgtgatc atgcctaata ttacttagta   1019460
acactcacct tgtattaact tgtgatttaa gtatagcaca agtaagttat tttgtaaacc   1019520
tttacataca acttttttta aaacttaact atgttctaaa attcatcaaa cagaggctct   1019580
gtttttattt atttttgtaa atcaaaacaa aaacaggaag acagaaaaat aaaaaagtag   1019640
ctacattttt aaaattcatt aagtctaata aacaaagaac acaagaaact ataaaacaaa   1019700
atacagttat ttttttaaaa gaatgattca taaagaaata acctctaagg taaatctatg   1019760
gtgtaaacaa ggttcacaaa cggcacttct actgtagcta cagcaactgt ccaataattt   1019820
tctacagcag tttttacagc ccagccaatc gcaccactta ttacagcaac aaatccagat   1019880
gtaacaggat taaccgcaaa ttgtttcaaa tgccatccag catatccagt agcgaaagct   1019940
ccagcagccc agccacccat ccccctcact tgaggaccaa gattgaaacg aaaacctaca   1020000
ggacctcttt cgtaaacgtt gggtaactct tttacagctc catacatcaa acttgcttct   1020060
tgtacagaaa taccaatatt ttttgctaac tcttcaggag tgccttttaa atttatattt   1020120
ccaaatttat ctacataaaa ataatcttcc aaaatttgac cagcatttac aatatcttct   1020180
gaaaccgaaa cattataaaa tttattccca tcaacattca aaacaatatc atttgcttta   1020240
tctactgtag ttagggcact atctgcaaat acagaaccac taaccatagg taaggctgat   1020300
aagaatattg aaacaatacc tagtcctaca actaacgctt taaaactctt tttagtagcc   1020360
gtttatcttc tccttttata aaacaatgaa tgaaatgtgc atctaaatat agtttattct   1020420
ggcaatattg tttccgtatt tttccttcct agctcgtaaa ataaactata tcctattttt   1020480
attatacttc atatagttac tttctaattc atattaactt gtgatttaag tatagcacaa   1020540
gtaagttatt ttgtaagcct ttacatacaa ctttttttaa atttttttag attcatgttc   1020600
ctaaactagg aggactttct tacacgcgtt ctttccatga agttgctgtt ctttgaagaa   1020660
ctttgttgag ttcgtcaatg ttttcaaatc cagttgtgcg aacgcattcg cgagctgctg   1020720
cttcaccatc tttgatgtaa gcttcaactg atcctgccca tgtagcacgg ccacaaagaa   1020780
ctccgttaaa gttcgcacct gattcatgag caaatacaag agtatcttgg aagagtttag   1020840
ctgatacacc agcactcaag tagatgtatg gcaagttcgt tgcttcatct tgcgctttga   1020900
agaaggctgc tgcttcttca cgtgtataaa ctacttcacc ttcagcgaag ccttcaacat   1020960
atttaatgtt aacaggaact tcaactttca aaacatcaat gttaaagcgt gggtctgaaa   1021020
agactttcat agcgccgata actttgtgtg gttttacttt agcgtattct acagaacctg   1021080
catccgcaat tttttcatcg taagcaagga tttcaaggaa gaatgggata tcttcagcca   1021140
cacactcaga accgatgcgt tcgatgtagg cttgtttttc ttgattgagt tcgtctgagc   1021200
tatctacatc atagtaaagc aagaatttaa ctgcatctgc accttcttct ttaatacgtt   1021260
ttgcagacca aacatccaag cagtctggca agcgttttgt gcttgttgtg tcataacctg   1021320
ttttttcata agcaaggaga agaccagctt tttcatcaag agctttagtt gctggaagtc   1021380
catactcagg gtcaagaagc atagatgaag catatttagt caattcatct gctaccaaga   1021440
ctttaagttc ttccatttgg gccacagttg gttcttctgt ttggtgttta accatgaggc   1021500
gtttcaaagc accacgttgg tcaaatgcaa gagctgagat gataccattt tcatcagaaa   1021560
gtttttctaa gcgtacacgt ttttgttctg ttaaagccat tttatacctc ttttactatt   1021620
aattgatcat atagagcttg atagttggcc atgttgacat gaccagtcat tttttcttga   1021680
gcattgagca taccaaggac atttgccttg atgagtaatt ctgcatccga ttctttgtga   1021740
agaagtcctg aagaaattcc tgccacagta gagtctccag atccaacagg atttaccacc   1021800
tgaattctag gaatatctac cttgtagaaa gtgtcaccat gtttggcaaa agtaccgttg   1021860
gcaccaagtg aaacgataat ccattcaatc cctgcaaaca aaggttcttg aagtacttct   1021920
tttaattcat ccaaatcctc agaaacttct cttccaagaa gctgagacaa ttcttcatta   1021980
tttggtttga tgactgttgg tttatggggt gattcaagaa cagcctgaag tgctgcacct   1022040
gagcagtcca agactacatg cttgccagct tgattagcaa gttctaccaa gctcgcatag   1022100
taatcaactg gaaggccagc tggcagacta cctgagatgg ctactacttc aactgactcc   1022160
aagagttttt tgaaatgttc caaaaactct tgaccttcct gttccaatac ttcaggacct   1022220
ttttcaagaa cttctgtttg gttgtctccg tggagaatag cgatacagtt acgagtttct   1022280
cccttaattg agaagaaatc tttctttact tgattatcga tatgttcaac caaaaactca   1022340
ccaagtttgc cacccactaa accagtagca agaacagaat cgccaaattc tgaaagtact   1022400
cgggtaacat tgagtccctt accaccagcc gttttggtta catccaccac acgattgaca   1022460
gtatcaatct tcaactcatc caagggatag gaaatatcga tggatgggtt cattgtgact   1022520
gttaaaatca taggtcacct cttagtcgtg gtattctcca cgatcccatt tctcaaggaa   1022580
ttctgtaaag aagtttgcgt ctgtttgttg agcattgtga ctttcaacat gttcaatttt   1022640
cgcaatcaat tttttgtttt cttcagttgg tttgtattca gcatggatga aagcttcgat   1022700
gatatcacac ataagcaatt caccagtaat tttaccacca aaaccaataa cgttagcgtt   1022760
caattgttct ttagcataaa gggctgttgt catatcacga accaaggcag aacgaacacc   1022820
tggaacttta tttacagcgt tgttgatacc aacaccagta ccacagatac atactccaag   1022880
atcagcttga ccgctagtta cagcttcccc tactttttta ccaaagattg ggtagtgagt   1022940
ccgtgtatgg tcataggtac caaagtcaat gacttcatat ccttttgatt tcaaaaattc   1023000
tgaaaccgcc attttttcat cagttacgat gtggtcacat ccaattgcaa ttctcatttt   1023060
taacttacct ttcttactat aatctaatta gcccattttg ttcaacatgt caacccggat   1023120
ttggtgacga ccaccgtcgt atttaccatt aacaaatcct ttagcgatat ttttagccaa   1023180
ttcatcacca acaagttgtg ctcccatagt gatcatacgt gagttgttgt ggccacgagt   1023240
catataagct gaacgttcgt cagatacttc tgcagcaacc attcctttga tcttagttgc   1023300
aactataaat ggaccagctc cataagcatc aatcacgata ccaaggtttt gttcttcttt   1023360
gtttacttct gcagcaacag cgagagtcac atcaacaaag tcttgacctt cagctgtaac   1023420
atccacaagg tggaagtttt ctttttctaa gaagtctttc acaacttctt tcaatctcaa   1023480
acctgcagca tctgcaccga taacaataga catattgtat actccttttt attttttcta   1023540
tgctggattc cagcagtgta ttgactgtct ttaaaaaaca gtcaattagt cctcacaaac   1023600
ctaatatact actattgttt gaagaagtca acagcttttg tttgtttttg ttatttattt   1023660
tttacttttt tataaaactt ctatctcaaa ccctaattct tcaacctgat tggcttctaa   1023720
gagacaaaca ttcttcttat cttctaaatg atctccttct tcaagggatg ttgacaagcc   1023780
agaccatggt tcaaaggtaa tgaaaggtcc cttgttcaaa gttgaccaga tgatgaggtt   1023840
tggaaattct gcaaaatgca ctttcaatcc cttatcatgt ttaagagaac gaagggcaat   1023900
tgttcgagat tgcaattcat ccaaagtcac tgcatctgtg ctgaaaagat cataactaag   1023960
atctatttct ttttgtccct ctagccatgg acttctatct tggaaatcca acatacctgt   1024020
ttctgggaaa ggacgtggaa cagagcaaat ctcttctttc tcaaactcta gataataatc   1024080
ttcatagact tcatcatcaa gtagaggaca attaaatcct ggatgtccac caataaagta   1024140
aggcctgacc ttgctagttt ctttattaga cttcctgaaa aactagaatc ctagttcatg   1024200
attgataata ccagcaatca aattcattcg taatccgaag cgtttacgat gatttcgata   1024260
ggttgttgaa aacattttaa acgtttttac tttggcaaag atgttctcaa ccttgcttct   1024320
ctccttagat agcgcatggt tataggcttt atcttcaact gttagcggct tgagtttgct   1024380
ggatttacgt ggagtttgtg cttgaggata tatcttcatg ggtccttgat aaccactgtc   1024440
agccaagatt ttaccagctt gtccgatatt tctgcgactc attttgaaca acttcatatc   1024500
atgacaatag ttcacagtga tatccaaaga aacaattctc ccttgacttg tgacaatcgc   1024560
ttgagccttc atagcgtgaa atttcttttt accagaataa ttcgctaatt ctttttttag   1024620
gtcgattgat ttttacttcc gtcgcatcaa tcattaccgt gtcttcagaa ctgagaggag   1024680
ttcttgaaat cgtaacacca cctttgaaca agagttactt caacccattg gctccgacgg   1024740
agtaagttgc tttcgtggat accaaaatca gccgcaattt cttcataagt gcggtattct   1024800
cgcacatagt gaagagtggc cataagaagg tcttctaggc ttaatttagg ttttcgtcca   1024860
ccttttgcgt gtttaagttg ataagctgtt tttaacacag ctaacatctc ttcaaaagtc   1024920
gtgcgctgaa caccaacaag acatttaaat cgtgtatcag ttagttgttt acttgcttca   1024980
tcattcatag aactactata ccatgttttg tttcgcagga agtctaatat tgtcaaatac   1025040
tggaacgctc attgctggga tacggaataa gattggccca gcttcgataa ctgggatacc   1025100
tggttcaaaa ccaaggtctg ttgcagcgat tggtgtaaag atatcgtaac ctttcataag   1025160
gtcttcgttt acatctttca ccataactgc atcacagtga acatcgtaac cacggtttga   1025220
aagttcttct tctagagcac ttttaatttg gtgacttgag ttaacacctg caccgcaggc   1025280
agcaagaatt ttaatcattt ggatttcctc cgattttatt ttttaataga caagattaag   1025340
cggttgcttc agcaatgtaa gcataaaggg cttctggttc agaaattttt gataggtctt   1025400
caagatgacc atttcctgtg aagaagtcca ttaactgagc aagaatgttc gtttgacttg   1025460
aacttgaatt attgatgata aagaagagca aggatacttc tacttcctta cctggcgcaa   1025520
tcatattatg gaaagtcacc ggtttctcta atcgaacaac caccactttc tcagctagat   1025580
tatgaacaat atctgtgtga ggaatcatta catttgcaag tcctttccta gaaattccat   1025640
atataaacca gttggaaatg acttttcacg cgtgatcaag gcttcacgat aagttggagt   1025700
gacaatttct cgttcttcca acaagcttgc tacctgatca aaaagttatt cttgattatc   1025760
cgcttctaag caaaacacaa ggtttttgtc aaagaaataa tctaatacca taaggttttc   1025820
ccttctttcc attaacttta tgctataagt ataacactat atgaaatcgt tgttaattac   1025880
tttctattct tttttgtctc tttttttata tttttgtttt gtttatagtt tgttatataa   1025940
aaataaacac acaaacaaat actccaagca tttttctgtt ctaatactca atgaaaatca   1026000
aagagcaaac taggaagcta gccgcagttg ttcaaaacac agttttgagg ttgtagatga   1026060
aactgacgaa gtcactcaaa acatggtttt gaggttgtag atgaaactga cgaagtcgat   1026120
aaccatacat acggtaaggc gacgctgacg tggtttgaag agattttcga agagtataaa   1026180
aactaaaaaa gcagaccatc taagcctgct ttactattga ttcttatata aatttcctgt   1026240
gaacaaggaa aggcatttct gataacttat tcttcatcca tactcaagac gctgaggaag   1026300
gcttcttgcg gaacttcaac tgatccgatg gatttcatgc gtttcttacc agctttttgt   1026360
ttttcaagga gtttacgctt acgagaaacg tcaccaccat aacatttagc aagtacgttc   1026420
ttacgaaggg ccttgatatc agtacgagcg acaatcttgt gtccaatagc cgcttggatt   1026480
ggaacttcaa attgttggcg agggatgatt ttcttgagtt tatcaacgat gagtttccca   1026540
cgttcgtagg caaagtcctt gtgaacgata aagctgaggg catccacctt atctccattg   1026600
agaagaatat ccattttcac cagcttagat gggcgatatt ctgacaattc gtagtcaaag   1026660
cttgcataac cacgtgtcga agacttaagt ttatcaaaga agtcaaagac aatttcagca   1026720
agaggaattt gatagataac attgacacgg ttatcatcaa tatagtccat agtcacaaag   1026780
tccccacgct tacgctgagc tagctccatt actgctccga cgaactcctg tggtaccatg   1026840
atttgcgcct tgacataagg ctcttcaatg gtcgcaatct tagttgggtc tggaaactca   1026900
gatgggttag acacatccat agactcaccg tcggtcaaat taactttgta aataacagac   1026960
ggagctgtca tgatgaggtc aatattgaac tcacgctcta aacgttcctg gataacatcc   1027020
atatggagaa gtccaagaaa tccacaacgg aaaccaaatc caagtgcctg agatgtttct   1027080
ggttcaaact gaagactagc atcattcagt tgcaattttt caagcgcttc acgcaggtca   1027140
ttgtacttgt ttgattcgat tgggtagaga cccgcaaaga ccataggatt catctgctta   1027200
taaccatgta atggttctgc cgcaggattg gttgccaagg taacggtatc acccacacga   1027260
gtatcctgaa ccgtcttgat agacgccgca atgtaaccaa catcaccagt cgcaaggaaa   1027320
tcacgaccaa ccgcttttgg tgtaaaaata ccgacttcgg ccacatcaaa ggtcttacta   1027380
ttgctcatga gctgaatctt atcaccaggt ttgaccactc cgtccatgac acgcacttgg   1027440
aggataaccc cacggtaagc atcgtaaaca gagtcgaaaa tcaaggcctt aagtggcgcc   1027500
gtcacatcac ccgttggtgc tggtactttt tctacaattt gctcgaggat ttcttcaatc   1027560
ccaataccag ccttggcaga agccaaaact gcttcactgg catccaaacc aatcacatct   1027620
tcaatctctg tacgcacgcg ctccggatct gcagccggca ggtcaatttt attaatgata   1027680
ggcatgattt ccaaatcatt atccaaagcc agataaacgt tggcaagagt ttgagcctca   1027740
attccttgag ccgcatcgac caccaaaata gcaccctcac aggcagctag cgaacgtgaa   1027800
acttcatagg taaagtcaac gtgccctggt gtgtcaatca agtggaaaat ataagtttcc   1027860
ccatcttttg cagtgtaatt caactcgatg gcattcaact taatagtaat tccacgttcc   1027920
cgctctagct ccatgctatc caaaagctgg gcctgcattt cacgacttga aaccgtctct   1027980
gttttttcca aaatgcggtc tgctagagtt gattttccgt ggtcaatatg ggcgataata   1028040
gagaagttac ggatcttctc ctgtcgtttt ttcaattctt ctaagttcat gattctcttc   1028100
ctttcagggt atctatttat tataaattgt ttttgatatt ttgacaagac cataccctgc   1028160
taggagtact aatcttcagc gacaaagccg tcattttcga taaagtggtg ttctgtcatt   1028220
ccttggtctg taaagacaat cccgtgaagg acaccaccat aaacagctcc tccatccatt   1028280
ccaatcttgc catcttctgt agtccaaagc tcagatgtac cgcgttcttg ctgtaacaaa   1028340
ccatagaccg gtgtatgacc gaagacaatg gtttttccag tatgattttc agctccgtgg   1028400
aatggttttc taagccatac ttttttataa tctgttgttt catgccagtc gtccaaggtc   1028460
aaatcaatac ctgcgtgaac aaagatatac ttgtctgtct ctactacaaa tggcatttga   1028520
cgaatgaatt cgaccaagtc tgccgcttca gcgcaacccg cttggcatct tctactccat   1028580
caactggtgc atccaaggga cgacctagga tagagttaat ggttgtatct ccaccattgc   1028640
gactataatg gtcataactt tcttctgggt catctagcca agtcaaaaac atatactcgt   1028700
ggtttccgga caaacagata gccccttgat tgtccaccaa gtccttgacc atttcaagaa   1028760
cacggtgact atcctcacct ctgtcaatca aatcacctag aaagagcaac tggggctgac   1028820
catcccaggt tttgagaagg tcttccagca tcccagcttt tccgtgaaca tctccaatta   1028880
cataataatc tgtcatctta tttctccctg tttctcaaca attctcttgc ttgcgtcagg   1028940
gctgcttctg tcacatcatc acctgccaac atcttggcaa cttcctccac tcgctcttcg   1029000
accgtcaaga gacgaacagt cgaaaccgtt gaatggtcat tactaatctt ctcaataaag   1029060
aattgataat ctgcaatcgc aattacttgt ggcaaatggg agatagccaa aacctgacca   1029120
tgctgaccaa ttttatgaat tttctgagca atagcttgag caacacgacc tgaaactccc   1029180
gtatccacct catcaaagac aatgctagtc ttgccttctt tacgtgaaaa ggcagactta   1029240
atggctaaca tgagacgaga taattcccct ccagaagcaa ccttaaccaa gggtttaaag   1029300
tcttctccag ggttggttga aatataaaac tcaaccattt tatttccctc acgactgaat   1029360
tttcccttac taaaacgaac ctgaaactgg gctttttcca tataaagatc ttgcagttct   1029420
tgtttaatct cagcttcgag ttgctgagcc aaattatgac gagcagaagc aagttgacct   1029480
gccaaattga caagattgac ttccaacttc ttaagctctg cttccatgtc ctcagacgaa   1029540
agattattgc ctgtcaagag attgtattct tccgtaatct tggcaaaata aagcaaaaca   1029600
tcatcaacag tcccaccata cttacgagta atagtatgaa ggaggtccaa acgattctca   1029660
acctgcatca ggcgattgcc atcaaaatca aggtcctcaa tgatagcttc caaacgtttg   1029720
ctaatgtctt ctaaaacata gtaggtctca gacagatagc ttgaaatttc acggtattca   1029780
ggatcatact cttcgacact ttccatgtca ttcatagctg aacgaacatt ggccagactt   1029840
gaaaaatctt cattgtccaa catactgtag gcattggtca gtgtatccgc aatatttttg   1029900
tggttgagga gtttatctcg ctcttgattg agagccaagt cttctccagc ctgcaagttt   1029960
gctgcctcaa tctctgccat ttgaaattcc aacatttcga tacgtgcctt gtgttcctgt   1030020
tggtttttct tgacttccag aacctgcttg cgcattttcc gataggcatc aaaactcgtt   1030080
tgataggttt ctttcaagtc ccaaaaagcg gcatcaccaa attcatccaa catctggata   1030140
tgcagttggg gacgcattaa ctcctcatgg tcatgctgac catgaatatc tacaagatgt   1030200
tgcccaatag ctcgcaaaac agacagatta accatctgac catttacacg gctgatacta   1030260
cgaccatttt gcaagatttc ccgacggatg ataatttcat cacctaattc taaaccttgc   1030320
tcatcaaaaa tttcctgtaa aagacgacta ttctcaactg agaaaagccc ctcaatctct   1030380
gcctttggtg caccatgacg aataacatct gtcgtcgcac gagctcccaa catcatattc   1030440
atggcatcaa tgataatcga cttccctgca cccgtttcac cagtcaggac agtcatcccc   1030500
ttttcaaaat tgagggaaat agcctcaata atggcaaagt tttttatcga aatttcaagt   1030560
aacatataga cctaccaatt ttttacttgt tcaaagattt cctctgctag acttccactt   1030620
ctggcaatga ctaaaatcga gctatcatca gtcaaacagc taaaaatctt gtctgcaaaa   1030680
gtctcgatta actgagcttt tacaaaagcc gtatttcctg gaataacttg gagattgatc   1030740
atcttatcca tcaattcagc cgattcgata ttgtcttcag ccagttgcag actttttacg   1030800
attgattttg gcaattcgta gacataggtg ttgtctctca aaggaatttt gacaatacct   1030860
aactctttga tatctcggga taccgtcgcc tgagtggcag tgatacctgc ttctttcaaa   1030920
tgttctacaa tttcttcttg cgtgccgatt tgataatctg tcaccaatct tctaattttt   1030980
tcaagtctct cttttttatt catttttaaa ttgactatgc gccctctcta ctgcttcttt   1031040
aatctcagca agaatctgat tgcttgctga cttttctttt ttcaaatacg ctaaaaattc   1031100
aatatttcca tgtccacctt ggatgggaga aaagtccaag ccaaggactg aaaaacctac   1031160
ctctactgcc atagctgtta cagattcaag gacattctga tgaaccttag catctcgaat   1031220
aattccattt ttcccaatct gctcacgtcc tgcctcaaac tgaggtttga caagtgctac   1031280
cacctgacct tgatcagcca agacacggtg caaggctggc aaaatcagac taagggaaat   1031340
gaaactcaca tcaatactgg caaagctcgg ctcctgctcg aaatcagtct tttcagcata   1031400
gcggaaattg aactgctcca tgctgacaac tcgtgggtct tggcgtaatt tccaagccaa   1031460
ctgattggta ccaacatcga ctgcaaagac caacttggca ctattctgta gcatgacatc   1031520
ggtaaaacct ccagtagagg ccccgatatc aatcgtagtc gcgccatcca ccgacaaatc   1031580
aaagacctgc aagccttttc cagtttcaaa ccaccacggc tgacatactt gagtttctcc   1031640
cccttgagtt ttaattcggt gtcatctgga attttctctc ctggcttgtc aaaccgttct   1031700
ccattaagga ctgctacgac taggccagcc atcacacctc gcttggcctg ctctctcgtt   1031760
tcaaacaacc cctgtttata agctagtaca tccactcttt ccttagccat tgattctcaa   1031820
actttctact acacttacaa tcgattctgt ttcaaaggga agctgctggg caatttcttc   1031880
taatttttca ttagcttgat ccagggtttg gttacaaaag gcaatggact cttccaagcc   1031940
caacagggca ggataggttg atttttctgc ctgcagatcc ttttgaggtg tcttgccgat   1032000
ttcctcaaaa ctagctgtca catccagtac atcatctctg acttgaaaag caagtccaat   1032060
caattcaccc acagttttca gcttcacctg catttcaggt gacaattcag ctataatagc   1032120
tgccgcttgg aagggatagg ctagtaactt cccagtctta ttggcatgaa tagtctgaag   1032180
ttcttccaaa gacaagtgct ggtgttcgcc ctccatatcc aaaacttgcc ctgctaccat   1032240
acccagacta cctgaagcaa gggataagtt ggcaatcaag tccaccttaa tctgacttgg   1032300
caaatctgcc tgcgcaatca aggcatatga gtctaagaat aaggcatctc cagccaaaat   1032360
ggccatagct tcaccgaatt tcttgtgatt ggttaaccgc cctcttcgat aatcgtcatc   1032420
atccatagca ggaaggtcat cgtgaatcaa gctccctgta tgaatcatct ctaaggcagt   1032480
agctacctgc gcgtgagcag gtttgatggt aacctgcaag gcttccagaa cttctaacaa   1032540
gagaaaaggc cgaatacgct tgccaccagc atgaatagaa tagagaacag actcccgtaa   1032600
actagaggca aactgctggt ctccataaaa atcttccaaa gccgactcga caagagctaa   1032660
tttttcttgc tttttcattc aaaatcactt tctgttccgt cttcttgcat gaccttgacc   1032720
aaggtctttt cagccttgtc cagcgtagct tggagctctt ttgacaagac catgcccttt   1032780
tgaaaggcag taatcgcatc ttccagagca atttcaccat tttccaaact ttggacaatg   1032840
gtttccagtt ctgctagatt ttcctcaaat ttcttttgtt ttgacatctt taacctctaa   1032900
ttctacttga ccatctcgca tcaaaagcgt tacttggtct tttttcttca aactctcaac   1032960
cgaatctaca acggactctt cttttttgac aatagcataa ccacgcgcca cgattcggct   1033020
agtatccaac atgagcaaag cttccgaaag tcgcttggcc tcagcaacct tggcgtcata   1033080
aactaacgcc atttggctac ctaagagctt gtccaactgt cctaaacggt cttgatagcg   1033140
ttggattttg gtaacaggtg ataattgtac taattgatga gttcttgctt gaactaattg   1033200
tttgttatca gaaatccgag ttcgcaaact ttgtttcaaa cgcagttgca gttggtccaa   1033260
gcgttgcaaa taaccgtcat acaagcgctc aggttgtcta aagataacag actgactgca   1033320
ttttttcaaa gcctcttgtt tcttagatag aacatttcgg actgccgtta ccatccgttt   1033380
ttcctgattt tgcaaatgag ctaatacatc caacttggtc acaggtgttg ccagttcagc   1033440
cgccgctgtt ggcgttgcag cgcgtcgatc tgccacaaaa tctgccaagg tcacatccgt   1033500
ctcatgcccc acactagaga taactggcaa acgagattca aaaatagctc gtaccacaat   1033560
ttcttcgtta aaggcccaga gatcctcaat agaaccacct ccacgaccaa taatgagcaa   1033620
atccaaatcg tcccgttgat tagcacgcgc aatatttcta gcaatttcct ccgcagcccc   1033680
ttcaccttga accttggtcg gataaagaag gatgtcaaca cctgggaatc gcctgctgac   1033740
ggtcgtgata atatctcgaa taacggctcc actacggctg gttactacac caattctctt   1033800
agaaaattgg ggcagagctt gcttgaagcg ttcttgaaac aggccttctt ctgtcaattt   1033860
tttcttaagt tgttcaaact gaatcgcaag cgccccaacc ccatcaggct cagctttttc   1033920
aatgatgatg gagtagctac cacttggttc atagacctgt acacgcccaa tcacattgat   1033980
cttcattcct tcttccaggt caaaccctaa tttctgataa atcccagacc agatggtcgc   1034040
ttgaataact gcatggtcat cctttaggga gaaatattgg tgagtaggtc gtttacgaaa   1034100
gttggaaact tgaccagtta aatagacccg ttccaagtat gggtctttat cgaatttcat   1034160
tttcagatac ttggtcaaag ttgttaccga taaatacttt tccatctcca cctactattc   1034220
atttacttgc tctttcatgg gtattattat accaaaaata tgcctaaaaa tctccattta   1034280
tgtaccatta tgagggaaaa atagaaaaag gaggcaaggc ctccacatgt gattatttgc   1034340
tgtttcgagc ttcttccaaa atctttgcaa tcttggtcgt caacaggtcg atagccacgg   1034400
tattgctaac cccttcagga atgacgatat cagcataacg cttagttgac tcgataaact   1034460
ggtggtacat tggtttgacc acacctaagt actggttaat aacgctatca aggctacggc   1034520
cacgctcctc catatcacgc ttgatacgac gaataatgcg cacatcgtca tccgtatcca   1034580
caaaaatctt gatatccatc aaatcgcgca gacgcttgtc ctccaagacc aaaataccct   1034640
caacgataaa gacatcttga ggttcctgac gataggtctt gctactccgt gtatgctctg   1034700
tatagtcgta ggtcgggatg tccaccggac gccctgccaa caattcctta atctgctcga   1034760
tcatcaagtc tgtatcaaag gcaaaaggat ggtcatagtt ggttttgaca cgctcttcaa   1034820
aggtcaaatg agactgatcc ttgtagtatg aatcatgctc aatcatggaa atcttttcat   1034880
caggaaaatg cgataaaatg gctcttgaaa cactggtttt accaccacca gaaccacctg   1034940
tcactccaat aatgattggt ctattttgca tgctatcctc cgttatttta tccgtcgtct   1035000
attctatcac attttttaca aaatttatag tctcatcagc aaaaaacacc agagtcttcc   1035060
ctctgatgtt cgacagtttt aacgaaagcc ctgtagggtt tgagcaagca tctgcaagaa   1035120
agccagtctc cctctttcct ggctaggagc tttggcaatc cataaaccaa aatcaatgac   1035180
agacttaggt gcctggtaat gatgcgtcat gaggtaaagt gacaaccctt gactcaaatt   1035240
ggccatgacc gattggtatt tttcatttct gtctaaattt tgtatagcaa gacgaaacag   1035300
gtgactcaac tcactatttt catttatttc tttttgttga agaagttgct ccaccctttc   1035360
tcgaaactca tttcgcatca tggaattatc acaccaaatc ctgggcctaa gttcccatca   1035420
gaacctgtaa tggactctaa atatttatct gaaagaattt taaattgctt catttcacac   1035480
ctctaaattt ctatatagat tatttgagta cctacaactc gcaacaattg gaatattata   1035540
attcccaaaa ccattctact attagtatgg ggttttatca agcaattgtt atctatcacc   1035600
cgatttttat tcctaaacga tctagctaaa aaccttcctt ggcttataga gattgccccg   1035660
tttttctaga atggctaaca atttatcatc ttcaaaggca gccagttctt tgtccgtttg   1035720
gtctagctca ataaaacgac caaagcgaac ttctgtagcc tcttctggac ttaggaaaac   1035780
tttgacaagg tcacctgtcc caatctctaa aggatggaga aaatctaatt gcccagcctc   1035840
tactttttca gcaatttcct ccaaggcaag agcgtcttct aattgtaagc cagcagcact   1035900
agtacgagtc aaatgggaca tatgagccgc ataaccaagc ttttcaccca aatcaactga   1035960
caaagtacgg atgtacgtcc ctttactgca ttttacacga aaagtgaatc gggcaagttg   1036020
gccatcataa gaaatcggac ttgttcgctc aaattgataa atggtcacct gacgttctgg   1036080
acgctccact tcctgaccag cacgcgcata ctcatagagc ttgcgaccat taaccttaac   1036140
tgccgaatac atagggggaa tctgagtaat aggcccagtc aagctagcaa tcgcttcatc   1036200
aacaagcttt tcatccaaga gagacaaaac aggggtttct gcgaccactt ccccactagc   1036260
atcctcagtc ttcgtggaat agcccagagt gatttccccc tcatagatct taccctcgtc   1036320
ctgcataaac tcgaccatgc gtgtcgcctt gccaaccgca atcggcaaaa cacccaccac   1036380
atccggatcc aaggttccac catgaccaat tttcttggtt cccaaaatct tacgcagttt   1036440
aaaaaccgca tcatgcgagg tcattcctgc ttcctttttt aagttaataa taccgttcat   1036500
ttttgctttc tactccccct tcagtgcttc gaacttcgct ttcattgttg gatttttccg   1036560
ggtcaatttt ttaacagaga catcttccaa tttgttgtta gctaaacgga gttggttttc   1036620
agatgtggtc aggaatttct taacctcttc catgcgtttg atggccttgt cgatttcatc   1036680
aatagctttt ccaaagttag tcgaagctga attatagttc ttagcaaaag ctagcttaaa   1036740
ggcatccaaa tcttcctcaa aatgcgtaat gtcaatattt tgctcgcgaa ccaaggccaa   1036800
ctcctgcttg tattttaggg aatttagcgc cgcattacgt aagagaccaa tcaattggat   1036860
aaagaattga ggacgaacaa catacatttt ttcatactcg tgactgacgt caacaatccc   1036920
tgtgttaaag tagtcattat cagcctcaag catggtcacc aaaacggcat actcacagtt   1036980
cttctcccga cggtccttgt ccaattcctt gtaaaaatct gcattcttgt gcttcttctc   1037040
tgttccgtcc gcttcgtttt tcatctcaaa catgatagaa atgatttcaa ctccattttc   1037100
atcacactca cggaagataa agtccccttt agacccacgc gaagagacct tgttatcctt   1037160
ctcaaagtaa gcatttggaa aggcgaaact acgaaccttg ttaaactcac tctctgcata   1037220
ctgttctagg ctttccccaa tcgcttttgt agattgttga gccttaaaat tcttataaaa   1037280
ctcgacttgt tcactagctg ccttgagctg ggcttcgtag ttttgcttaa cagaagccaa   1037340
agataattca ttttcctttt cctgcaaaag tagttggttt ttaacctgat cccgttcttt   1037400
ttctaggtca gaaagggtct tttgtagttg attttcatgc tccaaacgca aggtagccaa   1037460
ctgattttct aagagctgta cttccttgtc cttagccaag agagcctcat ggcttgtctg   1037520
ttcaacctct ttcttggcca attctttttc tgtatcaaag ttttggatct gactctgtaa   1037580
ttgcgcaatt tcttgatcct tctgagccag tttagtctgt tgctcattca tggccttttg   1037640
ctcagccaag gccagttcct gcttcatcct atcgtgtagt tccttatcaa actctgccgt   1037700
tctcacttgg gacaagagtt cggcatactg actctcattt actgtaaaga cttccccaca   1037760
gttgggacat ttgatttcgt tcatatcgtt cctctttcta gacttctgta accattatat   1037820
catgcctgag ggaaaatcaa aaacagtgag tcgaagccca ctgtttatct tcttttactt   1037880
taaatttttt ccaaggccaa gcgcaagtct tcaatcaaat cttctacatt ttcaagaccg   1037940
attgacaaac gaatttagtt tggtgtgaca cctgctgctt ctaggtcttt ttctgacaat   1038000
tgaccgtgag tggttgttgc tggatggaca acaagcgatt tagcatctgc cgcgtttgca   1038060
aggtcagaaa agatttctaa attatcaatg accttgcgtg cttcttcctc gccacctttg   1038120
acgtggaagg taaagattga accgacacct tttggcaagt atttctcagc caaggcatga   1038180
taaggactat ctgcaagttt tggataattt accttttcta ccttaggatg gttgacaaga   1038240
aaatcaacaa ttgtctcagc attttgtaca tggcgttcca cacgaagtga agaggtttca   1038300
agtctttgta gcaagaggaa agcattgaat ggtgacaagg ctgcacctgt atcacgaagc   1038360
aattgaactc gaacagctat aataaaggct gctgcaccca catcacgagt atagctcaaa   1038420
ttgtggcagc ttggaccctc gtcaacaaat tgagggaatt tccctgaagc cgtccagtca   1038480
aaacgaccac tatcgacaat tattcctcca atagttgtac catgcccacc gataaactta   1038540
gtcacagagt gaatggcaat gtcaacgcca tgagagaaga cgttaatcaa ataaggtgtt   1038600
gcaaaagtat tgtctgacac aagtgggatt tgatgtttat gagcaatctc tgccagtttt   1038660
tccaggtctg gaatattaat caaggggtta cccaaggttt caatcaagac aagcttggta   1038720
ttgtctttga tagctgcttc tacttcctcc aaattatcaa tatcgaaaaa ggttgttgtg   1038780
ataccataac gaggaagggg ttctttcaaa agattgaagg ttccaccgta aatagtcgaa   1038840
gcagccacta catggtcacc agcatgggca atcgccaaaa tcgtataagt cactgcagtc   1038900
atacctgatg ctgttgctag cgcttcaaca ccaccttcaa gggcagctgt tgtaggattg   1038960
gtgatacgag tataaatgtt ccctggtttc ctcaaggcaa acagatcggc accttcctac   1039020
gtgtcatcaa aaacaaaaaa tgttgtttga taaatcggca ctgcacgaga cttagtagct   1039080
ggagccacaa cttgaccagc atgtagttgt agagtttcaa atttaaaatc acaagtcata   1039140
aggtgacctc catattattt tattaaggat attgtagcac cttgagttat agtttacaaa   1039200
tatcagtttt ctatattttg atataagaaa tagctattac cttattttga aaatgaaaaa   1039260
agcacgactc aatcgtgctc attttcttaa tctacataag tatcttcgtt tttattgagg   1039320
aaggcatatg gaagacccat caagaggcct cctccgataa agtttccgat gaaagtcaca   1039380
ccccagtggc gaagcatatt tccaacaccg aagttggcaa ttgaatccgc agcaacactg   1039440
aatttcacaa tcgcgaaaga agcaaagttc gccgcaatgt gctcgtttgt taagaataca   1039500
aacatgtaaa tagctgacaa cacaagccaa agtttggcac caccatcttt gaccaaaata   1039560
aatgacagaa tcgcaatatt tacaaaaata tttgccaaaa tcgcctcaag caagaccaat   1039620
tcatttgagc ggcctaactt catctcaaca acacctgaga tgaaactatc gtgtgtcaga   1039680
ttcgcatagg ctgccgaatg agcaaagccc caccctgcta tcaaggctcc gataaggttg   1039740
aacaaggtac agtatagtaa aatctcagct gtttttctcc aagagatttt ttttaagaaa   1039800
ctaccagcag tcaagaacat catgtttgaa gtgaccaact cggcattcaa aaaaacaatg   1039860
taggccaagc cccaagcaaa aacgaatgga aagaggaagc gtccactacc tggtgcaatt   1039920
ttattaatca agtcagcccc aactgcacct gcagcagtac tgaaggttaa aaatgcacct   1039980
gcgaacatcg aacgaatcgc atacttaaat ttgctttgac tataaagact ttctttctta   1040040
ttgcaagcaa attcaatctt tgagataaat tccgaagaaa ccataataaa ctcctaaatc   1040100
ttttttcttg ataattatat cacaaacttt aggttttagg aagcgttttc tgtatttcat   1040160
aaaagtttat agtagattga aactagaata gtacacctct acttctaaaa cattgttaga   1040220
aatcgatttg actgtcctga tcgatttgtc ctattcttat ttcattttac tatattttta   1040280
tgaaaatctt aaaaaatcag tgaaatcatg gatttcactg atttgtatta ataaaattgt   1040340
ttatatggtt gattgaaagc tgttaggatt tcattagatg tttgtgaata atcttttgtt   1040400
tctttcaaat cacctttgac aataatacgt tctgtagcag caaggtcttc acaggttact   1040460
aatgtgattt cattgacccc atctctatca tcaacttcat caacacgatc cggtgtcaca   1040520
cgtttgactt cacgtatttc ataagtataa actttatttt tatcggttag ataaatcttc   1040580
atgccatttt tagcattatc taaaggagaa aataacattt tattagcatt atcaacacca   1040640
aagatatggt gactagctag actataattt ccttctccca ttacttgctc gcgtttcatt   1040700
gtaccagctc cgtagaagag attaacatta tcaagtcctt taaaaatcgg caaattcatt   1040760
tccaattcag gaattgcaat tcccccaata actggtaatt tttgagcatc ccattgagaa   1040820
gttagaacag cttccgaaga gatagctttg acagaatcaa agtcaaaatt gccttctgta   1040880
tcctgatttt cttctaattt ttcttttgat acctggctaa cttgatactt attggtattc   1040940
cagactatga aaatatttcg aatttgagta ttaaaaatca aagccagtga cagtaatatc   1041000
agaaatcctg ctaggatatt tgtcagcaga ttttttcgct tgtttttctt tttattattt   1041060
ttttgagaca ttatgcttca ccttctgttt cgttttctgt cccaacttct tctttttctg   1041120
ccaccgcaac cgttgtgaaa gtcactatct gagcatcttg atccaggcgc attactttaa   1041180
ctcccatagt tgcacgtcct gtttgtgaaa tattggcaag attggttcga atcatgacac   1041240
ctgtatcagt gataatcatc aaatcctcat ccccttgaac agtcataaga ccggccagca   1041300
agccattttt ttcggtaatt ttagctgtct gcattccctt accaccacga ccttttgttg   1041360
ggtattcagt agcgactgta cgcttaccat atcctttttc tgtgataata agaacctcat   1041420
cttgatcagt aatcaagctg gcaccaacaa ctgtgtctcc ttcacgaagg ttaacacctt   1041480
tcacaccagt ggcgatacgg ctcataccac gaacggcgat tgattaaagc gaactgcata   1041540
accaaacttg gtaccaatga taatatccat atctccttct gccaacaaga cattgattaa   1041600
ctcatcttca tcctttaaat tcagcgcttt gagaccattt tgacgaatat tggcaaactc   1041660
cttaacactg gttctcttca caataccgtg acgggttgta aagaagagat aagcatcatc   1041720
actgcgatca gactcaacat tgataaccgt ctgaatactt tcgtcttcat ccaatttcaa   1041780
gagattgact actggtagcc ctttggcagt ccgaccatac tcaggaattt cataaccttt   1041840
aagacgatag acacgtccct tgtttgtgaa gaagagcaga tgatcatggg tgctagttga   1041900
cactaactca cgaacaaagt catcatcttt cactcccgtt ccttggacac cacgaccccc   1041960
acgtttttga gcagtgaact cgtcctgatc caaacgctta atgtagcctc tgttagaaag   1042020
ggtaatcaag acatccgatt cttcaatcaa gtcctcatcc tcgagactca agacctgtcc   1042080
aatcatcaac tctgtacggc gcttatcaga aaatttacgt ttaacttcat ccaattcgtc   1042140
tttgataatt tgagaaacac gttcaggctt agcaagaata tctgctaaat ccgcaatcag   1042200
agccaagagg tcatcatact cagattgaat cttatcgcgt tccaaacctg tcaaacgacg   1042260
aagacgcata tcaaggatag cttgactttg acgttcagaa agcttaaact tgctcatcaa   1042320
ctcagcttga gcttccgcat ccgtttcact agcacggatg atacgaatca cttcgtcgat   1042380
atggtctagc gcaatcaaga gaccttctaa gatatgagcg cgcgcttccg ctttttcctt   1042440
atcaaaacgt gtacgacgaa caaccacttc tttttggtgc tcgatataag catccaaaat   1042500
ctgacgaaga gacaaaattt tcggtatacc attttggata gcgagcatat tgaaaccaaa   1042560
attggtttgc atttgggtca ttttgaagag gttattgaga ataacattgg ctgaggcgtc   1042620
gcgcttgact tcaataacaa atcgaacacc ttcacggttt gactcatcac gtactgctgt   1042680
gataccctca atgcgttttt cctgaaccaa gcgaacaata tgctcatgca ccttggtttt   1042740
attgaccatg taaggaaatt ctgttacaac gatacgctca cgaccagtct tagtcgtttc   1042800
aatctctgta cgagaacgta ggacaatcga acctttacct gtttcataag ccttatggat   1042860
acctgatttc cccatgacaa gagcaccagt tggaaaatct ggtccaggca agacttccat   1042920
caagtccttg gtagtcactt caggattatc catgaccaac ttcactgcat caatggtttc   1042980
acccagatta tgaggtggaa tattggttgc catcccaacc gcgataccag ttgctccatt   1043040
aaccaaaagg tttggaaaac gcgctggcaa gaccaagggt tcccgttcat tggcatcata   1043100
gttatcaacg aaatcaactg tatttttgtt gatatcacga agcatttcca gagcaatctt   1043160
gctcatacgt gcctcggtat aacgttgagc ggcagcacta tctccatcca tggaaccaaa   1043220
attcccatga ccatctacaa gcatgtaacg gtagctccac cattgagcca tacggaccat   1043280
ggcttcataa atagaggaat ccccgtgtgg gtgatattta cccatgacat cccctgtaat   1043340
acgagcagat tttttatggg gtttgtctgg ggtcacaccc aattcattca ttccgtagag   1043400
aatgcgacgg tgaacaggtt ttaagccatc tcgaacatca ggaagagctc gcgctacgat   1043460
aacactcatg gcgtagtcga taaaacttgc cttcatctcc tttgtcagat tgacattcac   1043520
taaattttta tcctgcatta ataaatgcct catttcacaa ttagtaagta acaacattat   1043580
accataaatt cccatctatt tcagcctcta aaccactaaa acgtttacat cgagaactat   1043640
aaggcatatt cgtgacaaag ttttttaaaa gtgatagaat gaagttgtct agggaaaatc   1043700
ccctaataaa attaaggaga tgtttaaaac aatgacttca actaaacaac acaaaaaagt   1043760
tatccttgtc ggtgatggtg ctgtaggttc atcttacgct tttgcacttg ttaaccaagg   1043820
aattgcacaa gagcttggaa ttatcgaaat tccacaattg catgaaaaag ctgttggtga   1043880
tgcgcttgac cttagtcacg cccttgcctt cacttcacct aaaaaaatct atgcagctca   1043940
atactctgac tgtgcagacg ctgaccttgt tgtgatcact gcaggtgcac ctcaaaaacc   1044000
aggtgaaact cgtcttgacc ttgtaggtaa aaaccttgct atcaacaaat caatcgtaac   1044060
tcaagttgtt gaatctggtt tcaaaggtat cttccttgtt gctgctaacc cagttgacgt   1044120
tttgacttac tcaacttgga aattctctgg tttccctaaa gaacgcgtta tcggttcagg   1044180
tacttcactt gactcagctc gtttccgtca agcacttgct gaaaaattgg atgtggatgc   1044240
tcgttcagtg cacgcctaca tcatgggtga acacggtgac tctgagttcg ctgtttggtc   1044300
acacgctaac atcgctggtg taaaccttga agaattcctt aaagacactc aaaatgttca   1044360
agaagctgaa ttgattgaat tgttcgaagg tgttcgtgat gcagcctaca caatcatcaa   1044420
caaaaaaggt gcaacatact acggtatcgc agtagccctt gctcgtatca ctaaagcaat   1044480
ccttgacgat gaaaacgcag tacttccact ttcagtattc caagaaggtc aatacggagt   1044540
tgagaatgtc tttatcggtc aaccagctgt tgttggtgca catggtatcg ttcgtccagt   1044600
aaatatccca ttgaacgacg cagaaactca aaaaatgcaa gcatctgcta aagaattaca   1044660
agctatcatt gacgaagcat ggaaaaaccc agaattccaa gaagcttcta aaaactaatt   1044720
taactataga caactccttg aattatcagg gagttgtttt tttctgtatt atagtaggtt   1044780
gaagttgaaa tagcccccca ttactctaaa acgttgttat aaaatgcttt aaattcctaa   1044840
ttgatttgtt catatcttat ttcaatccat tatacatctt cccacaataa aacgcataat   1044900
accaaggatt gtctgaactg ccccccaaaa gttagatttt ttctgtctaa cttttggggg   1044960
gcagtacaaa agcactcaat attatgcgtt ttttctgatt tcaaagaatt ttgactcggc   1045020
cttcttttta attattttca aaataggaat caaccaactt ttgaatgctc ccttctttag   1045080
ccgctggaat ggtatctgct aaaacaaaat tcttcctact gatatcttta gaaagattgc   1045140
caaatataaa attagtggaa atgttataga taatctcaga cggagcaaat ccataaactt   1045200
gcttttccaa aatatgtttt aagcgttctt caggatttgg aaaggcctct ttcaagccat   1045260
tgctattata taaccgcttc acaagttctg caatatagag gcctgacttc atatataaat   1045320
caataaaagt cttagatgga tcatcaaaaa tccctggatt ttccttttcc aaatcatcta   1045380
ccatcctttt caccactcgt ttaggagtga aaatttggtt ggtcttctgc ggtggaatat   1045440
agtcaaaaat gtcttctttt tgatctttaa aataatccgc caactccttt ttcttgcgaa   1045500
gaaattcttg aatagcttcg tcaaatgttg ctttatcaaa gagatgccct gcaaaatcct   1045560
gcccaccatc tcgcaaatat ctaaactgat caatcgtaat ccctgttact tcataaaaaa   1045620
catgttcagg aacaaaggca tcaaaattat caagtgttag agtttgatca ccgtaagcca   1045680
taataaaact tggaattgtt cttgcaaacc ctcgtaaatg gtcacgaatt tcatcttgag   1045740
ctgattgttt caactgttcc acacgtttta tctcaacctg ttcgataaat ttctcaggca   1045800
ttttttccac ttcttttttg agtgtttgtt ctagtttttc tttatgaatg agtttatttt   1045860
cttctaaacg tttttccaaa tcttcttgaa tcttatcttt ttgcgcttta tcatttgctt   1045920
ctttgagctg ctgttgcaac tcttgcttga tatgagcttc agaaattttt ctttcgatat   1045980
cattttttcg aatttcattc tcaagtgttg ctgtaatttg tttcttaatt tgctcagttt   1046040
cccttgtttt tagagaataa tctgctttca attcctctac aatcactgaa gaaacggtct   1046100
tactcaagtc attgaccagc tgtttttgag ttcgttcctc atcttttgtg actaactcag   1046160
caacagattc accaagtcca taaacttttt caccaaaaag tcgcatttgc tgattaacta   1046220
caatttcatg gtctactact gcatttccct catcatcgac tgtaacatct gaaaaatcta   1046280
ataaatcaga actatcttgt accttccctt ccttttcaac tggcagctca tttaaaatat   1046340
ctaaaactgt ttgacttgct tggaaaatac cactaatatt atcaaataag agattggaca   1046400
taaaacctcg tttaagaact tctctagctt ttatctggcg aggagtggtt agaactgcct   1046460
ttgcatcaat ttcaaccatc ttaccagcac ggtcttcggc aataattgga aagaagttta   1046520
ataattctct aatattttct tcgcgtgtag ctgaagttcc tctaccagct gcagttacaa   1046580
gcaataagtt gttggcaaac tcatcaaaga gaatcaaggt tctttccggc gcaaagtcaa   1046640
atacataggc tctttctttg cgaaagtgat ttcctttgtt atcgctccat gagtaaggat   1046700
tttgagcacg gaaggcggcc tgcatataaa gagctggtga tttcaaattt gataacatca   1046760
atacacctgt ccattcaggg atagtgacac ctgtcgtcag ctgaccaacg gatagggtaa   1046820
tggttttgtc attctctgct atcgcttttc taaccaagtc caaggatttg agtttgactt   1046880
tatcgtcttc ttcggacata cgtccgtcac cagcagctag aacgatctca tagttttcat   1046940
agattgggtg ttcttctagt agggctttta atgctttggc cgaagcgaca cgttctaaaa   1047000
gccaaaaagt atgcttgagt tcattacgga gttctttggt tgaaaatgga tatttttcat   1047060
tgcttgatag agtatctaac caatttctga catcatgctc atgaataaat ttccctttat   1047120
catctgtagc gaaaaattca cttaagtcaa aaacatagtc aatattttca ccatcgatct   1047180
gagcgccttt ttctaacttt tcgccaatca tctgagacat ttgataggta aagagattca   1047240
actgaggcaa gctttcataa ggattttcct cttcttgctc aagagaccac gaatacttag   1047300
cagcctgctc atcagcataa gaccagttgt agatttgttc ctctgtaaaa tctcctttag   1047360
ccaatgcttt aaatgatgta cctgacaaat gcagagtaaa atttcgtcga atcttattaa   1047420
aggcttggtc agtcttgaag gtatcaactc cttcatgagc ctcgtcaata accaacaagt   1047480
cccaatgcag atcagttacc catttgagtt tatcgtgctc tccacctaaa taaacagatc   1047540
ctttcaagtc ttggagactg ataaaagcaa gttgtcttac atcgtcagct aaaataccaa   1047600
gaaattcttg tcgtgacaag attggacgac tcttaaggct atctgattca gaaacaaact   1047660
tgtaagtcgt ttgacctgct atgaatgttt caaaatcatc ataccatgag ttagcaatgg   1047720
cagggcggtt tgttacaatt aggacattga cagcttccat ccgtcgagct aggtcatagg   1047780
tagacaaggt tttaccaaag cgtggcttgg cattccagag aaacttgcct ccagcatgtt   1047840
cttggaaata agctaatgtc ttagcaactg cttcttcttg ctcttgtcgc agagtatagt   1047900
cctgtccttt tccaggctga taaccagaca aatcatgctg aacaaactta tcaaaaagat   1047960
tttttgattt ttcaggagtt ccattaaaat agaaccattc cgtcttggga cgacgttcta   1048020
catcatggaa agaaaggaaa tggtggaaat catggtcctt gaaagttttc cccttatcag   1048080
gctcttctgt ataagctgca tcaccagtcc ataagacatc tgtagctata tgagctgtat   1048140
gcgtttgctc cttgatacgt tgtgtgacat cacgttctgt atacccaatc ttaatccagc   1048200
cttcattact ggttactgtc ggtgtggtgt aggcatagat tttaggatga atttctttag   1048260
tggttttaat ttctactggc ataagttttc cttttttgaa cgtttgctaa cgaagtcaat   1048320
ttatctaaca aatgactttc tcatctcata agtacaaaaa gggtcagggc atcgtatgct   1048380
tcctgaccta atcctatata gtcattttag atcattgagc actatttgtc aaataaaaat   1048440
acttttctaa tccatctccc ttacatgatt ctcaataaag gcaatttctt caggggaaag   1048500
gtcatatttt tgatcaagct ggcggtcaat atcagtcact gattgtgtcc aatcaatgtc   1048560
cgaattgacc gtaaagtctt ggagggggac gtaataccaa gttttgcgtg aattatgctg   1048620
agtaactttc aaaacaccta ataatactct agcgaattta gttttaataa atttaataca   1048680
agcatcggct tcaaattttg ttttaaaatt accaatagat aaaaaagtat ctgtatgccc   1048740
gattaggggt tccccgatta ggggtgttga taagacttca cctaaggcac cacttccatt   1048800
agcttctggt acaaaaacat tataattttc gaatgtttcc ggtaaatcta aatatttttt   1048860
attaatatat cgataaacac gttcggagcc aattcttcca agtagagcaa catggtcttt   1048920
ttcttcgttg tttttgaaaa caaaatctaa ctgagttagt gatttcgaaa caattttatt   1048980
ttttgtccct tttccttgca gcttttcagc atttggataa tcagaaaaaa gtttatttga   1049040
aaatctataa ataccttgag gataaactaa atcagaaaaa gtttcaaatt ctggatgttt   1049100
ttcgattttt tttacaatac cattcaaagt ttcaaaaata gtaaatactc cgattggtcc   1049160
caaatcttta tcaacatcac gataagttat tgctactcca cccttaatat ccgttcctgt   1049220
aaatacttta ccgcttttaa gttcatagaa ttgaactttt aaatgcttgt cttcaagcat   1049280
cttttccatc caatttttag gagtttgacc agctttaaat aaaaaccttg ctggggtgat   1049340
tagtatagat ttatctgcga ttttataagc ttcatcaata aaatagtgat atatcggctc   1049400
atctctggct tctcctgttt cctgatacgg aggatttcct atcacgacat caaatttcat   1049460
ttcactttcc tcgctagata ggcgctcaaa acctatcatt ctattctttt tccagtcttt   1049520
gatatgggtt ttagattctt ctacttcttg gacttctagc tcatccgcaa acaaactcaa   1049580
ttgttgagat tgcttttgtt tagctgaata aggactactt tttttcaatc catccatctg   1049640
aaagacattg taagagataa tagtcgcaat ttctttcttt tgctctaatg ttggttgatt   1049700
tccagtctta gctagataat agtcctcaaa agttgccaaa agattctcac gcgccaaaag   1049760
gagagaatct ccttgatact cataaccata cgaagcatga taagcatctt ttacaagttt   1049820
ataaaatgtg acttcatctg aaacctcacg actaatccgt tgcagttttc tatcaacaaa   1049880
accaactcgc tcagataatg gaatttcctc accagttacg gtatcatatc tcgttaccat   1049940
ataaggtgct tcaccacaag ttacctctaa ccatcgtaag tccacatact cctcaagact   1050000
taacgagcct aatttcgatt ctacatatcc attttgcttt gcgaccaacc acgttggtgt   1050060
aaacacttct gcccttattt ttgtccgatc tttttgttca tatttggatt tttcagatct   1050120
gggctgaatc aagttggcaa agtttccagt aaccttactt ggattgatgc gatcacttgg   1050180
agcaaatccc tttcctaaca attcataaga atgcgtagcc caaacaattg atttctttgt   1050240
cgttcgatct tttaaaagaa tttttaataa gtcagccgat tctttagcca aactttcttc   1050300
actaatatct attgtcatca gcaacctctc ttatattgta agccctatta tatcatattt   1050360
taaagaatga aaatttactt gaaaaaagta attcaataaa tatctctccg atgaccaact   1050420
tctagagtag caacgactaa ttcatcatct acaatttgta cgataactcg ataattacca   1050480
attctatagc gccattgacc aacgcgatta ccaaccaaag cctttccgtg tcgtcttggg   1050540
tcttccaaaa cattggtttg taaatagttt gtaattagct tctgcgtata acggtccaat   1050600
tttttcaatt gcttgataaa acgtcttgtt ggaactaatt tatacaaatt attcatcctt   1050660
caagcctaaa tcatgcatca tttcttccca agtaatgggt tcaactcctt tttccaagtc   1050720
ttctaaatac tcttgatagg ctaaatctgc cacacgagca tcgtattcat cttctagggc   1050780
ttcaagagtt ttggtgcgaa taagttccga aagggaaact ccttcaaact tagccattgc   1050840
tttcataaat gttttatcag cttcagaaac ttttaatgta atagtagtca tcttttgtgc   1050900
tccctttttt aatggtaaca ccattgtatt actttttagg tgttcagtca atataaaaag   1050960
aacaccttct cagcgttctt tctatatctc tgtcaatggt gttgcggtat ctggtgaggt   1051020
atcataaacc ttaaagtcta ctccgactcc cagatcagct tgagccagct gattgaccat   1051080
ggtcatatga gccagttcct tgatattgtt ttccttagat aaatgcccaa ggtaaatctt   1051140
cttagtacga tttcctagcg tccgaatcat agcttcagca ccgtcctcgt tagaaaggtg   1051200
accaaggtca gataggattc gttgtttgag tcgccaagcg taagaacctg atcgcaaaat   1051260
ctctacatca tggttggcct cgataagata accatccgca ttttcgacaa tgcccgccat   1051320
acggtcactg acataacctg tatctgtcaa gaggacaaaa ctcttatcat ccttcataaa   1051380
gcgatagaac tgcggtgcga ctgcatcatg gcttacacca aaactctcga tgtcgatatc   1051440
tccaaaggtt ttggttttac ccatttcaaa aatatgcttt tgcgaagaat ccaccttgcc   1051500
aagatattta ctattttcca tagcttgcca ggtcttttca ttggcataaa gatccatacc   1051560
atacttgcga gccaaaacgc ctactccatg gatatgatct gaatgctcat gggtaatcaa   1051620
gatggcatcc aggtcttctg gcttacggtt aatttcagct agcagactgg taattttctt   1051680
gccagacaag cctgcatcta ctaaaagctt cttttttgag gtttccagat aaaaagaatt   1051740
tccactggaa cccgacgcta aaatactgta tttaaagcct atttcactca ttctagtctt   1051800
ctacttcatc ctcccatact tcttctttca ctgcatcctt atcataaggg agtacaatgg   1051860
taaaggttga acccttgccg tattcactct tggcccaaat aaagccctta tgttgtttga   1051920
taatttcttt agcgatagac agtcctagac ctgtaccacc ttgtgcacga cttctagcac   1051980
gatccacacg atagaaacgg tcaaagatac gtggtaaatc ctgcttagga atccccaaac   1052040
cgtggtcaga aatggataaa atcatctggt cttcagttgt cttcattctg acagtgattt   1052100
tacccccatc tggcgaatac ttaatagcat tatttaaaat attgtcgaca acctgcgtca   1052160
tcttatctgt atcaatttcc atccagatag aattgatggg ataatctctc accaactcat   1052220
attttttctc cttttcctgt cctttcatct tgtcaaaacg attgaggata aaggtaataa   1052280
aagcagtgaa gttaatcagt tccacatcta ggtgactggt agcattatca atacgtgaaa   1052340
gatggaggag atccgtcacc atgcgcatca tacggttggt ctcatcaaga gaaaccttga   1052400
taaagtctgg tgctacagtt tcacacaaag ccccctcatc caaggcttca agataggatt   1052460
ttacgctagt cagaggagtc cgtaactcat ggctaacatt ggaaacaaag agtcttcgtt   1052520
cgcgttcttc cttctcctgc tccgtcgtat catgcaaaac agccaccaaa cctgaaataa   1052580
agccagactc tcgacgtatc aaggcaaagc gaactcgaag gttcaaatat tcgccattga   1052640
tatcttggga atctagcaac aattctggac tttgggtaat caaatcacgc aattcatagt   1052700
tttcttctat cttgagcaat tccaaaatgc ttctattcag aacatcttcc ttaaccaacc   1052760
ccagttgctt cttggctgta tcgttaatca tgataatctg accccgacgg ttagtcgcaa   1052820
gaaccccatc tgtcatataa aacagaatac tatttagcct cttactctct tgttctagat   1052880
tttcctgagt gagacgaata acctccgaca agtcattcaa attattggta atattggtga   1052940
tttcagaccc accttgcata tcaagaacct tggaataatc tcctgcaatc aaatctttaa   1053000
ccttttgatt gacttgcttc aactgaatat tatcacgtct attttccagt aataagaggg   1053060
tcacaacaag gatgaaacct aacaaaatca ggataaagat aaaatctctg gtaaaaatgg   1053120
tttgtttcag taaatcaagc attatttctc atgtaatacc ctacaccacg gcgcgtcaag   1053180
atatactctg gtcggctggg cgtatcttca atcttctcac gcagacgtcg tacagtcaca   1053240
tcaactgtac ggacatcacc aaaatagtca taaccccaga cagtctcaag caagtgttcg   1053300
cgcgtgatga cttgacctgt atgcgatgct aaatgataca aaagctcaaa ttcacgatgg   1053360
gttaagtcta gttcttcgcc atatttttta gccacgtagg cgtctggaac aatttctaaa   1053420
tccccaattt ggataggttg aggtttacta tctgcttcct gaccatctac tggcataggt   1053480
tgagaacgac gcagaagagc tttaacacgc gcctgcaact cacgattgga gaagggtttt   1053540
gttacatagt catctgcccc aagttccaaa ccgataacct tatcaaattc actatctttg   1053600
gctgaaagca taagaatggg cacactgctt gtcttacgaa tggtcttagc aacttctaaa   1053660
ccatcaattt ctggaagcat caaatccaga ataataatat ctggttgctc tgcttcaaat   1053720
tgctctagcg cttcacgacc attaaaagca gttacaactt cgtaaccttc cttggtcata   1053780
ttaaacttga taatatccga gattggtttc tcatcatcta caattagtat ttttttcata   1053840
tgttcacctt tttctctact attataccaa aaaaatagtc agaagacaca atagctagtc   1053900
ttggctactg tctaagttgg cttgtgcata aacctgccag attttttgtt ggggtttggc   1053960
aagtgggtaa ttcttgaatt cttctggtga aagccagcga acttccctat ctgaaaaatc   1054020
atggaagtca ctcacctgac ctgctacaat ctgtacatgc cattttcgat gactaaaaac   1054080
atgctggact gtatcaaaac aaacatcaag ccaatcaaca tctaggtcat agtcctgctg   1054140
gaaactctct tctggactgg gaccaaagtt cacactttct tccgcaacct gatgaaagag   1054200
gtcaaactgc tcttcttgcg aaaagttatc aacttctata aaggggaaat gccaaaaacc   1054260
tgccaagagc ttttcgcttt catttttttc aagtaaaaat tgtccttgag aatttttcac   1054320
aactaaggct ttaagataaa taggaaccgg ctttttctta ggagatttaa ttggataacg   1054380
gtccatggtt ccattctgat atgccgcact aaagtccttg actgggcttt cttcaggtct   1054440
gggatttaca ggagactcaa tatcagaccc taagtccatc aaggcttgat taaaatcacc   1054500
cggacgatcc ggattaatca agatctccat cattgcctga aaaatttttc gattacttgg   1054560
aatcccaata tcgtggttga cttcaaacag acgcgccaag acccgcatga cattaccatc   1054620
tacagctggc tcaggcaagt taaaagcaat actggaaatg gctcctgctg tgtaaggtcc   1054680
aatccctttc aagctggaaa ttccttcata ggtatttgga aattggccac caaagtcagt   1054740
cataatctgc tgggctgcag cctgcatatt gcgaactcga gaataatagc ccaagccctc   1054800
ccaagctttc agtaaactct cctcaggcgc agttgccaga ctttcgacag ttggaaacca   1054860
gtccaaaaat ctttcgtagt aagggataac tgtatccacc ctggtctgct gaagcatgat   1054920
ttcagatacc cagatgtgat aaggattttt acttctcctc caaggcaaat ctcttttgtt   1054980
ttcatcatac caagcgagaa gtttctcacg gaaagaaatg actttctcct ccggccacat   1055040
gacgataccg tattctttca aatctaacat atctctagta taacacagaa ggtttcacct   1055100
gtctttgtat ctgatttata atattttcaa tagatagtat ataacttttc tatctactta   1055160
tactcaatga aaatcaaaga gcaaactagg aagctagccg caggttgctc aaaacactgt   1055220
tttgaggttg tggatagaac tgacagagtc agtatcatat acctacggca aggtgaagct   1055280
gacgtagttt gaagagattt tcgaagagta taaatcttat tgatgaactg cttgcagtct   1055340
gagaaaaaat gagcttggat attatttcca aactcactta aagtcaattt caatccacta   1055400
gaacaagcct agtacagttc catcgctttc aacatccatg ttgagagctg ctggacgttt   1055460
tggaagacct ggcatggtca taacatcacc agttaaggca acgatgaagc ctgcacctaa   1055520
ttttggtacc aattcacgaa tggtaatttc aaagttttct ggtgctccaa gcgcatttgg   1055580
attgtctgag aaactgtatt gagttttagc catacagatt ggcaatttgt cccaaccgtt   1055640
ttgaacgatt tgagcaattt gtgtttgagc tttcttctca aagttcactt tgctaccacg   1055700
atagatttca gtgacaattt tttcaatctt ttcttggaca gaaaggtcat tatcatacaa   1055760
acgtttatag ttagctggat tttcagcaat tgtcttaaca actgtttcgg caagtgctac   1055820
tccaccttct gctccatcag cccagacact agccaattca actggtacat cgattgaggc   1055880
acagagttct tttaaggctg caatttcagc ttctgtatca gatacaaatt cgttaatagc   1055940
tacaactgct ggaataccga acttacggat attttcaacg tggcgtttca agttagcaaa   1056000
acctgcacga actgcctcta cattttcttc agtcagagcg tctttagcca caccaccatt   1056060
catcttaagg gcacgaaggg ttgcgacaat aacaactgca tctggagatg ttggcaagtt   1056120
tggtgtcttg atatcaagga atttctcagc accaaggtcc gcaccaaaac cagcttcagt   1056180
aacagtgtaa tcagccaagt gaagggctgt tgtcgtcgcc aaaacagagt tacagccatg   1056240
agcgatattg gcaaatggac caccgtgtac aaaggcaggt gtaccgtaaa ttgtctgaac   1056300
caagtttggc ttaatagcat ccttcaaaat caaagccaag gcaccctcaa cctgcaaatc   1056360
acctacagaa acaggcgtac ggtcatagcg ataaccaata acgatattcg ccaaacgacg   1056420
tttcaagtcc tcgatgtccg ttgccaagca aagaattgcc atgatttctg aagcaactgt   1056480
aatatcaaaa ccatcctcac gtggaatacc gtttagagga ccaccaagac caacagtcac   1056540
atggcggagc gtacggtcgt tcaagtccac aacgcgtttc cagaggatac gacgttgatc   1056600
aattcccagc tcattccctt ggtgcaagtg gttgtcaatc aaggcagaaa gggcattgtt   1056660
ggcagttgta atagcatgca tatctccagt aaagtggagg ttgatgtctt ccattggcag   1056720
aacttgtgca tacccaccac cagcagcacc acccttgatc cccatgactg gaccaagaga   1056780
cggttcgcgg atagcaatca tggttttctt gccaatcttg ttcaaggcat ccgcaagacc   1056840
aatggtaagc gtcgactttc cttcacctgc aggtgttggg ttgatggcag taaccaagat   1056900
caatttaccg actggattgc tctcaactgc acgaatttta tcaaagctga gtttagcctt   1056960
gtactttccg tacaactcca aatcgtcata agaaatacca agtttctcta caacatcaac   1057020
aattggcttc aactcaatac tctgtgcgat ttcaatatct gttttcattc aaaattcctc   1057080
taacctctta tatgataatt cattatatca caaaacaaga tttttaacat cctaaaactc   1057140
tctaaacgtt cgtaaatatc tctgttttta agacttttag agtcctttct taaattttat   1057200
atggctttat agtttgaaac tataataaat cttcgttttt accaaaaatt tatcactttc   1057260
attttactta ccgcttattt ttgtgtacaa tagtgctatg aaaattttag ttacatcggg   1057320
cggtaccagt gaagctatcg atagcgtccg ctctatcact aaccattcta caggtcactt   1057380
ggggaaaatt atcacagaga ctttgctttc tgcagggtat gaagtttgtt taattacgac   1057440
aaaacgagct ctgaagccag agcctcatcc taacctaagt attcgagaaa ttaccaatac   1057500
caaggacctt ctaatagaaa tgcaagaacg tgttcaggat tatcaggtct tgatccactc   1057560
aatggctgtt tctgactaca ctcctgttta tatgacaggg cttgaggaag ttcaggctag   1057620
ctccaatcta aaagaatttt taagcaagca aaatcatcag gccaagattt cttcaactga   1057680
tgaggttcag gttttgttcc ttaaaaagac acccaaaatc atatccctag tcaaggaatg   1057740
gaatcctact attcatctga ttggtttcaa actgctggtt gatgttaccg aagatcatct   1057800
ggttgacatt gcacgaaaaa gtcttatcaa gaatcaagca gatttaatca tcgcgaatga   1057860
cctgactcaa atttcagcag atcagcaccg agctatattt gttgagaaaa atcagcttca   1057920
aacagtccag actaaagaag aaattgcaga actcctcctt gaaaaaattc aagcctatca   1057980
ttcttagaaa ggaaaactat ggcaaacatt ctcttggctg taacgggttc aatcgcctct   1058040
tataagtcgg cagatttagt cagttctcta aaaaaacaag gccatcaagt cactgtctta   1058100
atgactcagg ctgctacaga gtttatccaa cctttgacac tacaggtact ctcacagaat   1058160
cctgtccact tggatgtcat gaaggaaccc tatcctgatc aggtcaatca tatcgaactt   1058220
ggaaaaaaag cagatttatt tatcgtggta cctgcaactg ctaacactat tgcaaaacta   1058280
gctcacggat ttgcggacaa catggtaacc agtacagctc tagccctacc aagtcatatt   1058340
cccaaactaa tagctcctgc tatgaataca aaaatgtatg accatccagt aactcagaat   1058400
aatctgaaaa cattagaaac ctacggctat cagctgattg ctcctaagga atccctacta   1058460
gcttgtggag accacggacg aggagcttta gctgacctca caattatttt agaaagaata   1058520
aaggaaacta tcgatgaaaa aacgctctaa tattgcaccc attgctatct tttttgctac   1058580
catgctcgtg atacactttc tgagctcact tatctttaac ctttttccat ttccaatcaa   1058640
accgaccatt gttcatattc ctgtcattat tgccagcatt atttatggtc cacgagttgg   1058700
ggttacactt ggatttttga tgggattact tagcttgacg gttaacacga ttacgattct   1058760
accgacaagc tacctcttct ctcccttcgt accaaacgga aacatctact cagctatcat   1058820
tgccatcgtc ccacgtattt tgattggttt aactccttac ttagtctata aactgatgaa   1058880
aaacaagact ggtctgattt tagctggagc ccttggttcc ttgacaaata ctatctttgt   1058940
ccttggagga atcttcttcc tatttggaaa tgtttataat ggaaatatcc aacttcttct   1059000
ggcaaccgtt atctcaacaa attcaattgc tgaattggtc atttctgcaa ttctaaccct   1059060
agccattgtt ccacgactac aaaccttgaa aaaataaaaa caatctccgc tttcaaacct   1059120
gaaggtggag attttgctct atacagtttc tttttaatga aatctttact atagtaaaac   1059180
gaaataagaa caggacaaat cgatcaggac agccaaatcg atttctaaca atgttttaga   1059240
agtagaggtg gactattcta gtttcaatct actataactt ttaactaaaa aatgatctat   1059300
aaacccaagt aaattcttgc tttattgtct ggtttattgt accatactag tgtatatgca   1059360
gttaaaaagg agattcttgt gaatacacgg aaaaagacac aatttatgac aatgacagcc   1059420
cttttaacgg ctattgcgat tttgattcca attgttatgc ctttcaagat tgtcattcca   1059480
cctgcttcct atactttggg gagccacatc gctattttta tagccatgtt cttgtcgccc   1059540
ttgatggcag tttttgtcat cctagcctct agttttggat ttttgatggc tggctatccc   1059600
atggttatcg tttttcgggc tttttcccat atatcttttg gtgctttagg agctctttac   1059660
ctacaaaaat tccccgatac cctagataaa ccaaaatctt cctggatttt caactttgtt   1059720
ttggctgttg ttcatgccct tgctgaagta ttggcctgtg tcgtttttta cgcaacttct   1059780
ggtaccaatg tagaaaatat gttttatgtt ctatttgtac tagttggatt tggtacaatt   1059840
atccatagta tggtagacta tacattagca ctagctgtct ataaagtgct tcgaaaacgc   1059900
cgttaaaagg aagaactatg acaaaagatc gcaaacaagc cctgctccaa ctcttgaaag   1059960
aagctcctaa agccctcaat ggccaaagat tagctgagca ctttcatgtc actcgacaag   1060020
ttattgttca agatattgca attttaagag ctgatggatc tccaattcta tctaccaatc   1060080
gtggttatat ctataaagat gctaatgcaa atacttatca tcacaaatta tttaaggtca   1060140
agcatgaagt tgaagaaatt ggacgagaat tacttgctat cgtagataat ggtggtcgcg   1060200
ttcaaaatat cttgattgat catcctgttt atggagagat tgaaacctta ctaaaactga   1060260
cctgtcgccg cgacgtgcaa cattttctag aacaagttga acgttctgac tttaagccaa   1060320
tttctgagtt aacagatggt attcattatc acctagttga agccgagaca caacaagacc   1060380
tccactatat cgaggaggcc ttggatcagc taggttattt agtaaaagac tagaagattt   1060440
tcttttccca atcgtcttct gtacggcgag ggtagaaaaa ctctgacttg tcgggagctt   1060500
ccatcatttc catcaatggt agcatatcat aggccagatt taagtttgga atctggtctt   1060560
tttgcaccca agaaacttct ccctcttctg aagattgaag ggtaccagag aactcagtcg   1060620
ccttataaca aatgacaata tagcgcccac ctgtatctag tggccaattt ttaatgccga   1060680
caagttgagg attttggata gtcaaccctg tttcttcgta gatttcacga atgacagact   1060740
ccgcaaaagc ctcatcattt tctacatgac ctccaggaaa ggcataacca gaccagcgat   1060800
tgttttcagg ggcgcgatac tgcatcacca cgcgctgagt ttcgaggtct tcaatcagac   1060860
agatatttgt taaaattgtt aattgggaac gggacataaa tttactcgct ttctaattta   1060920
ttaaattttc agacttggta ccatattagc ttttactttt gagaattatt tagaatagaa   1060980
taccatccgt ttttccttta taggctttcc aagttcaagt attttttctt gtccatcaaa   1061040
agtaaaaccc attttttgat agaaagcaat ggcgcgcttg ttatctttca atacccataa   1061100
gaaaatttca gaaaaatgat taagatcagt caaagctgct ttcactaact tttgtgcgat   1061160
tccttttcca taatagtctt ttaaaacata taaagcaata atttcaccag cttgaatagt   1061220
ctcatcacga cagttgccat aacttataaa accaactatc ttcacaccat ccatcgcaat   1061280
caatgtattt tctggatact tttgactaaa gagtcgacat ctttctaatg tcattgtctc   1061340
ctgaaattcc gcaggcaaaa ggtcatcata agcctctctc cacgtttgcc agtgaacgaa   1061400
ggatttacct tctatctctt caggagtttc cattgatttg ataataaccg tcatttattt   1061460
tctcccagtc ttctctcaaa ataccatatt taatactgtc aaaatattta ccttgataat   1061520
aacgaacttt tggaatatga gcttcttttt tcattcttaa tttttcagca agtttcatca   1061580
taccaatatt tcctgaccaa gttgtcaaac ccagatgctc caactccaag taatcctgaa   1061640
acgtcctatc tatccactgc aacatagcaa ctttcccaat accagtgttc cagaattttt   1061700
tatcataaat accaattccc aattccatcc atcttgtttc tttacatacc caataacgcg   1061760
aaacagtccc aactagttta tcatcaacaa aaataccaag gcgatttgag ttgcttaaaa   1061820
tggattctga tttttgtagt tcgaattctt taaaatttga aaaatactga taatcatcat   1061880
aatagggagc atcatactgt ttccaaactg gattaagctg tgaataagcc atttcccata   1061940
aagacatcaa atcttctttc tttaactttc ttaaataaat catactattc ccctaatcca   1062000
aggccttgac ttccagcatc atatcacgaa tctgagctgc tagttcaaag tcaagcactt   1062060
caactgcttc ttgcatttgt ttctcaagct ttttgactag ttctttgcgc tcttgtttgt   1062120
tgaggctatt gatatcgact tccttgtctt cttccttagc aactgccttg gtcacagcaa   1062180
tcaagtcacg gatttctttc ttgatggttt gtggaacgat accatgttct tcattatagg   1062240
ccatctggat tttgcgacgg cgggcagttt catcgatagc acgttgcata gactgggtaa   1062300
ccgtgtccgc atacatgata acatgacctt cgctattacg tgcagcacgt ccaatggtct   1062360
ggatgagtcc acgttcgttg cgaaggaaac cttccttgtc agcatcgaga atagctacga   1062420
ggctcacttc aggaacgtca attccttcac ggagcaggtt aattccgacc aagacatcaa   1062480
agacacccaa gcgcaggtca cggataatct ccgtccgttc caaggtcttg atatccgagt   1062540
gcatgtactt gaccttgata cccatttcct tgaagtagtc ggtcaaatcc tctgccattt   1062600
tcttggtcaa agttgtgata aaggtacgct catttttttc aacgcgggca ttgatttcac   1062660
ccaagaggtc atcaatctgt cccatagtcg gacggacttc cacctctgga tccaagagtc   1062720
ccgttggacg aatgatttgc tcaatcactg tctcggtctg ttcattttca tagtcaccag   1062780
gtgtcgctga aacgtaaaca atctgatgaa cgtgactctc aaactcctcc cgacggagag   1062840
gacgattgtc caaagcagac ggcaaacgga aaccataatt aaccagcatt tctttacgcg   1062900
aacggtctcc attgtacatg cccttgattt gccctatggt catatgactc tcgtcaatca   1062960
taatcaagaa atcatctggg aagaagtcga gaagcgtata aggaggctct ccttcgctcc   1063020
gtccatccat gtggcgagaa taattttcaa ccccattggt atagcccatc tcacgcaaca   1063080
tttcgatatc atactctgtc cgctgtttca aacgctgggc ttcaagcagt ttaccttcct   1063140
tttcaaagac agctaattgt tcttccaact cggcctgaat ctttgcaatg gcaacttcca   1063200
tgtggtcgtc attggtcaca aagtgtgtcg ctgggaaaat cgctaaatga tccacttctc   1063260
ccaacacctg acctgtcaga gcctcaactt cacgaatacg gtcaatttcg tctccaaaaa   1063320
attctactcg aaaggcatgt tcatctcggg aagctgggaa aatctctacc acatccccac   1063380
gaacgcgaaa tcttccgcgt tggaaatcaa tatcattacg ttcaaactga atatcgacca   1063440
agtcattcaa gagtttatca cgagaaatct ctagaccagg acggagacta acgacactat   1063500
cagcgtattc cttgggcgaa cccaaaccat agatacaaga gactgaggcc acgacaataa   1063560
catcattacg ctccaaaagg gctgaggtag ctgagtggcg aagcttgtca atctcgtcat   1063620
tgacagaact atccttctca atataggtat cgctagaagg gacataggcc tctggctggt   1063680
aataatcata gtaggatacg aaatactcaa ctgcattttc agggaaaaat tccttaaact   1063740
ccccatagag ctgaccagcc agagttttat tgtgggcaat aaccagagtt ggtttattga   1063800
ctttagaaat gacctgactc atagtatagg tcttccctgt tccagtcgcc cccatcagaa   1063860
tctgagcttt ttctcccccc tcaatgttat ccaccaactg ctcgatagct tggggttgat   1063920
ctcctgatgg ttgatatttt gatactagtt taaattgatt atctgtaatg tgattgatca   1063980
taagaatcct ctctccatgt gctattccta ttttagcata cttatagtat tttcacgaag   1064040
aaaaggacgg accgaagtca catcctttca ttttctttct ttaatttatt agcaagatag   1064100
acaatcagca gtagtaatac cagacttgtc ataatggaac cttctatgcc aaaagaacca   1064160
cctgatagcc aatcttgatt gccttgtggt aaaaaggtca tcagagacgt tctgacggtt   1064220
gaccactaac taaaatccca aagagattac cctgagcaaa attccaagca ccatgaatac   1064280
ctgcaacacc ccaaactgta tcagttttga gaaggtaaag agccatggca actccgaata   1064340
aaaagagatt tactagagat agaggggtga gaccagaatt gcccatatga agcagggtaa   1064400
agaacaggct agatataaga atagctagtt ttagattggt tcttgaggcc aattgaggaa   1064460
gtagccaagc acgggccacc acttcttctg ctgtcccctg taaaatccaa aatgggatag   1064520
taaagacgac aaaggcaaga gaataaggat tcaagtgaat ggattccaaa cgatattgac   1064580
ctaagaccac taaacctaac aaggtcagaa gaaaaagtgc caggcctaga ctaaatcctt   1064640
tcagaagatt gctgaggaaa ttctctctat aaaatcccaa ggttcgaata ggtcttttct   1064700
caacttttct tgtccatctg aacacagtgt taagaataaa accaaaggcc agtaatccta   1064760
aaattaaacg aaagtcactt gttttatccg tcaagctctg atgcaaggtc tgcaagtagc   1064820
ttgcaagatt ttgaccagcc tctccaaaat ttctagcaag tccgatgaga gctaacaagc   1064880
caataccata caaagtaaaa gccacaaact ctcctatgaa gacaaaaaca aaggctaaca   1064940
aggggcttgt gtaaatgttt aaactcattt ttgaagcttg gaagtcttta aatattcttt   1065000
tgttcttcat atccccgtcc tcttttcttc tatatatact attattatag cactttttaa   1065060
tagcaattca aggaaaggaa aaaatcgatg ttatattttc tgacacaaaa aatataaaaa   1065120
tttgcctttt tttacttttt ctgatataat gagagaatat tcggaaaagg agactaaaaa   1065180
tgaagaaaaa atttctagca tttttgctaa ttttattccc aattttctca ttaggtattg   1065240
ccaaagcaga aacgattaag attgtttctg ataccgccta tgcacctttt gagtttaaag   1065300
attcagatca aacttataaa ggaattgatg ttgacattat taacaaagtc gctgagatta   1065360
aaggctggaa cattcagatg tcctatcctg gatttgacgc agcagtcaat gcggttcaag   1065420
ctgggcaagc cgacgctatc atggcaggga tgacaaagac taaagaacgt gaaaaagtct   1065480
tcaccatgtc tgatacttac tatgatacaa aagttgtcat tgctactaca aagtcacaca   1065540
aaattagcaa gtacgaccaa ttaactggca aaaccgttgg tgttaaaaac ggaactgccg   1065600
ctcaacgttt ccttgaaaca atcaaagata aatacggctt tactattaaa acatttgaca   1065660
ctggtgattt aatgaacaac agcttgagtg ctggtgccat cgatgccatg atggatgaca   1065720
aacctgttat cgaatatgcc attaaccaag gtcaagacct ccatattgaa atggatggtg   1065780
aagctgtagg aagttttgct ttcggtgtga aaaaaggaag taaatacgag cacctggtta   1065840
ctgaatttaa ccaagccttg tctgaaatga aaaaagatgg tagtcttgat aaaattatca   1065900
agaaatggac tgcttcatca tcttcagcag tgccaactac aactactctc gcaggattaa   1065960
aagctattcc tgttaaggct aaatatatca ttgccagcga ttcttctttt gccccttttg   1066020
ttttccaaaa ttcaagcaac caatacactg gtattgatat ggaattgatt aaggcaatcg   1066080
ctaaagacca aggttttgaa attgaaatca ccaaccctgg ttttgatgct gctatcagtg   1066140
ctgtccaagc tggtcaagcc gatggtatca tcgctggtat gtctgtcaca gatgctcgta   1066200
aggcaacttt tgacttctca gaatcatact acactgctaa taccattctt ggtgtcaaag   1066260
aatcaagcaa tattgcttct tatgaagatc taaaaggaaa gacagtcggt gttaaaaacg   1066320
gaactgcttc tcaaaccttc ctaacagaaa atcaaagcaa atacggctac aaaatcaaaa   1066380
cctttgctga tggttcttca atgtatgaca gtttaaacac tggtgccatt gatgccgtta   1066440
tggatgatga acctgttctc aaatattcta tcagccaagg tcaaaaattg aaaactccaa   1066500
tctctggaac tccaatcggt gaaacagcct ttgccgttaa aaaaggagca aatccagaac   1066560
tgattgaaat gttcaacaac ggacttgcaa accttaaagc aaacggtgaa ttccaaaaga   1066620
ttcttgacaa atacctagct agcgaatctt caactgcttc aacaagtact gttgacgaaa   1066680
caacgctctg gggcttgctt caaaacaact acaaacaact ccttagcggt cttggtatca   1066740
ctcttgctct agctcttatc tcatttgcta ttgccattgt catcggaatt atcttcggta   1066800
tgtttagcgt tagcccatac aaatctcttc gcgtcatctc tgagattttc gttgacgtta   1066860
ttcgtggtat tccattgatg attcttgcag ccttcatctt ctggggaatt ccaaacttca   1066920
tcgagtctat cacaggccaa caaagcccaa ttaacgactt tgtagctgga accattgccc   1066980
tctcactcaa tgcggctgct tatatcgctg aaatcgttcg tggtggtatt caggccgttc   1067040
cagttggcca aatggaagcc agccgaagct tgggtatctc ttatggaaaa accatgcgta   1067100
agattatctt gccacaagca actaaattga tgttgccaaa ctttgtcaac caattcgtta   1067160
tcgctcttaa agatacaact atcgtatctg ctatcggttt ggttgaactc ttccaaactg   1067220
gtaagattat cattgctcgt aactaccaaa gtttcaagat gtatgcaatc cttgctatct   1067280
tctatcttgt aattatcaca cttttgacta gactagcgaa acgcttagaa aagaggattc   1067340
gttaatggca aaattaaaaa ttgatgtaaa tgatttacac aagcactatg gaaaaaatga   1067400
agtcctaaaa ggaattacga ctaagttcta tgaaggagat gttgtttgta tcatcggtcc   1067460
ttcaggttct ggtaagtcaa ctttcctccg tagcctcaat cttttagaag aagtcactag   1067520
cggtcacatc actgtgaacg gctatgattt aactgaaaaa acaaccaatg ttgaccacgt   1067580
ccgtgaaaat atcggcatgg tattccaaca cttcaacctc ttccctcata tgtctgtatt   1067640
ggacaacatc acctttgctc ctattgagca caagttgatg actaaggaag aagctgagga   1067700
attgggaatg gagttgcttg aaaaggttgg actagcagat aaagctaatg ccaatccaga   1067760
tagcctatca ggtggtcaaa aacaacgtgt ggccatcgct cgtggcctag caatgaatcc   1067820
agacatcatg ctcttcgatg aaccaacttc tgcccttgac cctgagatgg ttggagacgt   1067880
acttaacgtt atgaaggaat tggctgagca aggcatgacc atgattatcg taacccatga   1067940
gatgggattt gctcgtcagg ttgccaaccg cgttatcttt actgcagatg gcgagttcct   1068000
tgaagacgga acacctgacc aaatctttga taacccacaa caccctcgtc tgaaagagtt   1068060
cttagataag gtcttaaacg tctaaactca aactgtaagg atttccttgc agtttttcta   1068120
cctcgtattg gaatttttga tttttcggaa aattatgtta gaattaagtt tatgaaatga   1068180
ggtttcctca tacctagcaa gactaggaat aaaaatagaa attaggtagc tagatgtcat   1068240
ctaaggttat tgttacaatt ttcggtgcga gtggagacct ggctaaacgc aagctctacc   1068300
cttccctttt tagactatat caatccggca atctttccaa gcactttgcc gttattggaa   1068360
ctgcccgtag accttggagt aaggaatatt ttgaatctgt agttgtcgag tccatccttg   1068420
atttggcaga tagtaccgag caagcccaag aatttgctag ccacttctac tatcaaagcc   1068480
atgatgtcaa tgattcggaa cattatattg ctttgcgtca attacaagct gagcttaatg   1068540
aaaaatacca agctgaacac aataagctct tcttcttgtc tatggcacct cagttctttg   1068600
gaaccattgc caaacacctc aaatctgaaa acattgtcga tggcaaaggt tttgagcgct   1068660
tgatcgttga aaaaccattt ggtacagatt acgcaactgc aagcaagttg aatgacgaac   1068720
tcctagcaac atttgacgaa gaacaaattt tccgtatcga ccattatctt ggtaaggaaa   1068780
tgatccaaag catctttgca gttcgctttg caaacttgat ttttgaaaac gtttggaaca   1068840
aggattttat cgacaatgtt caaattacct ttgcggagcg cttgggtgta gaagaacgtg   1068900
gtggctacta tgaccaatcc ggtgccctcc gtgacatggt ccaaaaccac actctacaac   1068960
ttctttcgct cctcgccatg gacaaaccag caagcttcac aaaagacgag attcgtgctg   1069020
aaaagattaa ggtctttaaa aacctctatc atccaactga tgaagaactc aaagaacact   1069080
ttatccgtgg gcaataccgc tctggtaaga ttgatggcat gaaatacatc tcttatcgta   1069140
gcgagccaaa tgtgaatcca gaatcaacaa ctgaaacctt tacatctggt gccttctttg   1069200
tagacagcga tcgattccgt ggtgttcctt tctttttccg tacaggtaaa cgactgactg   1069260
aaaaaggaac tcatgtcaac atcgtcttta aacaaatgga ttctatcttt ggagaaccac   1069320
ttgctccaaa tattttgacc atctatattc aaccaacaga aggcttctct cttagcctaa   1069380
atgggaagca agtaggagaa gaatttaact tggctcctaa ctcacttgat taccgtacag   1069440
atgcgactgc aactggtgct tctccagaac catacgaaaa attgatttat gatgtcctaa   1069500
ataacaactc aactaacttt agccactggg atgaagtttg tgcgtcatgg aagttgattg   1069560
accgtattga aaagctctgg gctgaaaatg gtgccccact tcatgactat aaagctggaa   1069620
gcatgggacc tcaagccagc tttgacctac ttgaaaaatt cggtgccaaa tggacttggc   1069680
aaccagatat cacctatcgt caagatggtc gcttagaata aaaaaatttc ctgcaagttt   1069740
atgccttgca ggatttttgc ttctgattag attaaacctt ccaagagacc tttcataaag   1069800
ttttctgagt taaactctcc aatatcatcg attttttcac caaaaccaat caattttaca   1069860
ggaatattga gttcttcacg aatggctaga accacacctc ctcgagcagt tccatcaatc   1069920
ttagtcaaaa caattcccgt taaaggtgtg attttcgaaa attctttggc ctgtactagg   1069980
gcattttgac ctgttgatgc atcaagtgcc aagaaggttt catgtggtgc ttctggcaca   1070040
acacgtttga taatacgacc aatcttttcc aactcagcca taaggttatc cttattttgc   1070100
agacgaccag cagtatcaat catgagaata tcgatacctt cagtcacggc acgttccata   1070160
ccatcaaaga ccacgctggc tggatcagct ttttcaggtc cagttactac tggaacatct   1070220
actcgtcggc cccattcagc tagctgagct actgcacccg cacggaaggt atctgctgca   1070280
accagcatga ccttcttacc agcttgtttg tagcggtggg ctagttttcc gatagaagtt   1070340
gttttcccaa caccattcac accaacaaag agcataactg tcaagttatc ttggaagtgg   1070400
atgctttcat cgtagctacc atccttttca taaagctcaa ccaatttctc aatgatgaca   1070460
cgacgaagta catcaggttt cttggcattt tcaagcttgg cttcgtaacg tagttcctcc   1070520
gttaagttag aagcgacttg gacaccaaca tcactcataa tcagcagttc ttccagttcc   1070580
tcgaaaaatt cttcgtcaac agagcggaag ttagcaaaga aggcattcaa gcgggcaccg   1070640
aaacctgtgc gagttttctt aagactgcgg tcatattttt cctgaacagt ttcttctgtt   1070700
tgaggagctt ctggttcaag cacttcagaa ttattttctt ctacagttcc ttcgtgctca   1070760
agcttctctt cctctggtaa ttcttctgag tttggtaatt cttctatttc ttcttgagaa   1070820
acccctacag ctggctctga atcctgactt tcttcaactg tgtcttggat ttcctcttct   1070880
tggaacacag cttgttcaac aatttcaacc tctgcttctt cctgagaaac ttcctcaact   1070940
tctgtgaagg taggatcaac atcttcagac aaatcaagat tttccagagc ttcttttaca   1071000
acttcttcga ttttaggttc ttcttttttt ccgaatagac ggtcaaacaa tcccatatct   1071060
tagttctcct ttagcacata ttcttcgata gcccaggcga cagcttcctc atcgttggtc   1071120
atcggcgtca ctacatttgc ggctgccttt acttcaggaa cagcgttttg catagcaaca   1071180
ccaagacctg cccattcaat catagagagg tcattggcct cgtcaccaca agccatcact   1071240
tgactttggt cgattccaag atggctgatt agttttgcca aacctgttgc tttatgaaca   1071300
ttctttggtg accattctag caacatttca cgtgatttaa agatttcata ttggtcaaac   1071360
aattctggag aaatcttctg aatggctgca tccaagggtt cttgagcaaa ggcagtcacg   1071420
catttgttgt aggtcatttg actagataag tcttcaaagt ccactggaac aaaggtcaaa   1071480
gctggattga atttggcata aagactttct tggtccgatt ggatttgata aactgttcct   1071540
tctgagatgg catcaagagg cagtgataat ttctctgttt cttcatacaa acgtgccaca   1071600
tcatcatatg aaaagactgt tttatcaagg atttctcctg tatttttctg aactaatcca   1071660
ccattaaaag taatggtata ctcatcttcc tgaccgtcag tccctaactc atggagaaag   1071720
aaatccatgg cttttaaggg acgaccagtt gtcaatacga ccttgatacc acgatcacgc   1071780
gcagcttgca aggtttcctt ggtacgatcc gtcagccttt tatcagtagt cagcaaggtc   1071840
ccgtccaagt ccaatgcaat caattttata tctgccatta taagccctcc atataagcta   1071900
taaccgaccg ttccttatgg tgaccaatca cagtctttgc taattctaaa atttcaggtc   1071960
gtgcattttc aggagctaca ggatgtccca caacctgcat catatgtaag tcattaagat   1072020
tgtctccaaa agccatgacc tgatccattg tgataccaag ttttttaact aattcaacaa   1072080
tggccactcc cttatcgaca tagtccagaa caatatcaat ggattcaaag ccagttgtca   1072140
tggccttaac accaggaacg ttttcgttta cccaagcctc cccatcttcc agcgtttctt   1072200
ctgtgaagtt ggttgtaaat ttgaaaatgt catctgtgat atcttccaaa ctcgctactt   1072260
tttggatatt ttcattatag tgctgactca ctttcaaata ggtctcatca accgtatcta   1072320
gaacatatga acccttctta cccgtcaaga gcagtttatt gatatctaca taaggtgaag   1072380
ttttcagctt ttcaaaagtt gccagataaa agtcacgaga catagtcgct tcatacaagt   1072440
cctgaccttg atactctacc aaactgccat tttccgcgat gaaaataatg tcatcacgaa   1072500
caccagcaaa taatttttct agagacagaa atccccgacc cgaagctacc gcaaagtaaa   1072560
tccctttttc cttgtaggaa accaagagag acttgagacg atccatatca aagcgtccat   1072620
tcccatctag gaaggttccg tccatatccg ttgctactag tttaattgtc atccttcaat   1072680
actttctaaa tcttttaact taactgaaac aatctttgaa acacccgatt cttgcatggt   1072740
cactccatag atggaatcag ccgctgccat ggttccctta cggtgggtta cgacgatgaa   1072800
ctggctgtcc ttgtcaaagc ggttgaggta atccccaaaa cgtttaacat tggcttcatc   1072860
cagcgcagct tccacctcat ccaagataac aaatggaata gtcttgacac gaataatgga   1072920
gaagagcaag gcaagagccg atagggcttt ttcaccacca ctcatgagat taagagactg   1072980
gattttcttg cctggtggtt ggacagaaat ttcaacccca gctgtcagca agtctccttc   1073040
agtcaaaatg aggtcagcct gacctccacc aaacatctgc ttgaaggtca ctttaaagga   1073100
ctcacgaatg acctcaaagg ttgatttaaa gcgttccttg acctcatcat tcatctctgt   1073160
aatggtctca aggagcaggt ttttcgcaga caaaatatca tcacgttggc tatttaggaa   1073220
atccagacgg ttgtgaactt cttcgtactg ttcaatagcg tctaaattga caggacccag   1073280
tgagcgtata gccttctcta aatccttaac ttcttgctct gccagattga gattttccaa   1073340
ctcatgcgcc ttttctaaag cttctgtgta gctgatctgg tactggtctg ttaattgact   1073400
ttgtagatgg cgcaagcgct cgctaacctt ttctttcttg gcttcagcac gagtttgctt   1073460
gcgaatccac tcttcattct gctggcgagc ctgatccaaa tgactagcaa tatcatccag   1073520
ttgaccctca atatcatcca actcaaactg cttgcgaatc aaaccttgtt ggagatttgt   1073580
tttttgagtt ttggattctt ccgcctgttg actgagcaat tctgtatcaa ccttctcaag   1073640
attatcaatc ttttcttgaa gaaggcgctg gatttcctct tgttcaaaat caagattgtc   1073700
caattccttg cctaagcgtt caatatcagc aacttcataa cgtttttgcc cttgcagttc   1073760
tgtcttaagc aaacgagctt gcgctagctc ttcctgcaag ttttgatagc gttcttggat   1073820
ggcatttttg ttagacttaa tctcttcaat ctcagcttcc agattttgct tgtcactgga   1073880
gattgcagca agacgctctt ggcagttttc cttatccgct tgccaatctc cctcggaaag   1073940
acgatctatt tcctcttctt ggagtttcca aagagtttcc agttcttcaa cttgctgact   1074000
agtttgctga taagcgagga acaagccttg ctcctgaata cgtgcctgct ctccttgaga   1074060
tttaatagct tctaatgact cggtcaatct ggccatctca tcttgcaagg tcttcaaagt   1074120
cgcctcttct gaacccaagc ttgcttcttc ttcagcaatt tctttttgta attgctccag   1074180
ttctggcttg ataaaaatgc tgttattctg gcgattggca ccacctgcat aagaaccacc   1074240
tgtgcgcaac tctgtcccat ccaatgtcac catacgaacc tgataacgaa cttggcgagc   1074300
tgctgcacgc gcatgttcta cggtatcaaa gatagccgtc gtagctagca agttcttgaa   1074360
aatggcttcc agtctagtat caaaagtcac caactcatct gccatcccaa ggaaacctgg   1074420
gcttacagcg atagcatctt ggttctgact agaaatcgta cgcgccttga tagtggtcaa   1074480
aggaagaaag gttgcacgac cggctctgtt ccgtttaagg aagtcaatag ccttggttgc   1074540
cgactcttca tcttctacga tgatatgctg gctacttgcc cctaaggcaa tctctagggc   1074600
agtttgataa taaacatcaa aggtcagatg ctcactgact gcaccaataa tcccacctag   1074660
gcgatctttt tcttggagaa cactcttaac acctgcataa aagttactat gatttctcag   1074720
gatattttcc aaactttgag ctctggcctg cttgtttttg agattatcca gacggtcaaa   1074780
gagttggctt tgttgagctt gataggaagt tttctgctcc tcttgctcct tggcaatagc   1074840
ttggtagtca gccaataatt tctgaacctg ctccttggca gtttcaagct cttccttttg   1074900
ctgactagcc ttctctttag ctatagctaa ttgctctttc agcttttcta gttgatctgc   1074960
ttgtttttga gaaagctgac gactattttc caactcattc tcaatacggg tcaactggtt   1075020
tgagacatcc gcttcttctt gtaaaagagc tacaaagcgt tcacgtaaga gctcaatcat   1075080
ctgatcagga tcgtctgaga aagccagcaa ttcagcttct aaacgattga gtttttgatt   1075140
attttggact agatttccct ctaacagagc taaagagctt tctttatcag acttttcttt   1075200
gctgagtgaa tttctcttat cctccaaagc agccaaacgg gcttgtgcct cctgttgatt   1075260
caaggccact tgctcggact ccagtttcga tagggctaat tttctttcta aatcactaat   1075320
cagactagtc aagtccatca aactgccttg gtctttggcc atttcagcct gtaaatcttg   1075380
gcgttgcttt ttaagagttt gattttcttc ttctaatttt tcacgctttt ggtaataact   1075440
catcaagagt tcttgaacct gagtcaactc ttcttctgtc gactctagtt cagccttatt   1075500
ttccttgatt tgagcaacca gaacatctaa ataaatagcc ttacgttgtc cttccaagtc   1075560
taaaaactta cgggcattct cagcttgctt ctcaagaggc ttgatttgat tatccaactc   1075620
gtagataatg tcctctaagc ggtccagatt atcctgagtt tgctgcagtt tactctcggt   1075680
ttcttttctg cgagtcttgt attttaaaac tccagcagct tcttcaaaaa tagctcgtcg   1075740
ttcctcaggc ttggaattaa aaatctcctc aaccttccct tgggaaataa tagagaagga   1075800
atctcgtccc aatccagtat ccaagaagag gtcatgaata tcacgcagac ggactttctt   1075860
gccgtcaatc ttgtattcgc tatctccact acgatagaca tggcgttcca ccctgatttc   1075920
ttgacctgca tccttgataa atccgtcatg attatccaga gtcacaacta cagaagcata   1075980
attgagcggt ttgcgacttt cggttccagc aaagatgata tccggcatct tgcccccacg   1076040
gagactcttg acactagact cccccaaagc ccaacgcaga ctttctgtaa tattggactt   1076100
tccagatcca ttgggtccaa caactgccgt cacaccttgg tcaaaaacga ccttggtctt   1076160
atcagcaaaa gacttgaacc cctgaatttc gatttccttt aaatacatga atccagcccc   1076220
ttctcaacgg catttttggc agcttcctgc tctgctaatt tcttagaacg accttggcct   1076280
tgaccgatgc tcttaccttc aacaagaact tctacatcaa aaaccttatc gtgagcaggc   1076340
cctgtttcag aaatcacctg ataacgaata gccacatcac cattgacctg aagcaactct   1076400
tggagatggg ttttatagtc tgtaatcatc tcaaactcgc ctgcttcaac cttaggaatc   1076460
atgacttgat agataaattc cttgaccttg gccacatcct tatccaaaag aagggcacca   1076520
agaaaggctt caaaggcatc accaagaatg gtgtcacgat tgcgaccacc tgatttttct   1076580
tcccctttac ccaacttgat aaactggtca aactggcaat cacgcgcaaa accagctaaa   1076640
ctctcctcac ggacaatcat agcacggagt tttgataggt caccttcagg ctttttagga   1076700
tattttttat atagatattc tgaaatcaat aactgtagaa cagcgtctcc taaaaattcc   1076760
aagcgttcat tgtgtgaaat ttttaagagg cggtgctcat tggcataact cgtatgagta   1076820
aaggcagttt ccagtaactt tttgtctgca aattcgattg caaaatgatt ctttagtaca   1076880
gtttgtaatt ctttcatacc aacctctttc taactgataa tagtcctttt tattatatca   1076940
aaaaaagccc cctgagtcac tctaaaacgg gactggaaag catttgggaa ttctttagac   1077000
agagattctc agttttagcg gcaaatttgg gtcaggataa agaaaaaagc cctattaaag   1077060
gctttttagg atgtttacat ccaccctgag ggaatcgaac ccccatctca agaaccggaa   1077120
tcttacgtga tatccattac actaagggtg gaaacttgtt ttattataac agaaatttgc   1077180
tctaataaca agttttttgg tcaaagaccc cgtcttagtg ggaagcatcc ccattccaga   1077240
tggagttttt cacgatcaca taatcaacgt gtttaaggtc agcaacctga cgtccacctg   1077300
cataagaaat agcactttga aggtcttgtt ccatctcagt taaagtgtct tgcagatgac   1077360
ctttagcagg aagcaagata cgtttgcctt ccacattttt gtaagcacct ttttgatatt   1077420
gtgaggctga accataatat tctttgaact gttcaccatc gacttcaatc gttttccctg   1077480
gactttcaat gtgtcctgca aagagggaac caatcatgat catgctagca ccgaagcgga   1077540
tagacttagc aatatcaccg tgagtacgaa ttcctccatc agcgataatc ggtttacgcg   1077600
cagccttggc acaccagcgt agagcagcca actgccaacc acctgtacca aaaccagtct   1077660
taaccttggt gatacaaacc ttaccaggac cgattccgac cttagtagca tccgcaccag   1077720
cattttccaa ttcacgcaca gcttctggtg ttcccacatt tccagcaatg acaaaggtat   1077780
ctggcaattc tttcttgatg tgttgaatca tagaaatcac gctatccgca tgaccatgag   1077840
caatatcaat agtgatatac tcaggagtat cagccttgag ctggctaaca aaatcatact   1077900
cataatcctt aacaccgaca gagatagaag caatgagccc ttgattgtgc attcgtttaa   1077960
taaaaggaat gcgtcctgcc tcatcaaaac ggtgcataat gtagaagtaa ccacctttag   1078020
ccagttgctc tgctacattt tcatccaaaa tcgtctgcat attcgctggc acaacaggta   1078080
gtttaaaggt gtgatttcct aaagtgacac ttgtatccgc ttctgcacgg cttttaatga   1078140
cacatttatt tggaatcaat tgaatatctt cgtaatcaaa aattggaaat tcatttaaca   1078200
tatcgatgtc tcgtttcttt tgtaatgacc tacctatgct cttgcatcac tacgcctttt   1078260
ccgacgtttc cttaatttat tataaatcaa agtacagttt ttgtcaaatt attttatgaa   1078320
ttaaaatata tcgttcgggt tttacttgtg ttaaaaataa aagaaagagg ggaaattatt   1078380
ttctccccac ttcttcatca ataatcgctt taaaattttc ttctgaattt tccatcattt   1078440
tacaaaatgt actatagaat gaggcattct gagggattcg aatagaccac ttcttcaatt   1078500
gagctccata gccagctact tttcctattt cactatttac tgactgctcc atactaggaa   1078560
aaatcagtcc agccttctca gcttttaaaa tataagaata ggaaatcagc tggaataagt   1078620
cctcacggtt gattcctttt tcagtcaatt ccagtttttt atattttgca tctagaacaa   1078680
tctttcgttc tctgtcataa aaatctggat atacttttcg tttcccaaca gaaaatactg   1078740
aaattccatc cgtcttatcc ttatttctgg gatgtacaaa accttttggc aacaaggtgt   1078800
aaacatactc ttcccaaagc caggcaacat caaagagaat accatagatt ttttgatctt   1078860
gataccctaa accgtgcttt tcttggttta ggatcatcag acaaagttct tgtaagtttc   1078920
tgtactcgtg aaagtatgca tgacgtatag gtttagattg atttccccga ataatcttag   1078980
cacgatcagc tagtttataa gagggcgtta cacgcacgat ttcagatacg ttttcacgac   1079040
tagttgagag attatctagt accccttgac caatgctttt ctgattctta atgtattcaa   1079100
tagtgtgacg gaccaactgc atgaggggat tatcataggt gaactctctc gttgcgtagg   1079160
caatatttcc cgtgaaagga agatttttct tgagatggtt tcttacatca atcactccct   1079220
taacatgact gtcgttatga gaaaatcgat gatattcctt ataaagacct tttcgaatag   1079280
cagcttgtag atacttggga aagagataca ccaaaagttg ataaagcctc tcttcacgag   1079340
acaaagcaac atctaaacta gtgagattga tatgaagaac cttgtttaag agataatgca   1079400
aaaagtggtc attactctca tcagaaaatc gtgaggaaat cgttaatctt tcctgaccat   1079460
atccaagaaa accaatcacg ttccctgtct tgattttctg attgactgtt tcaaaaatct   1079520
tttggtcctt atccaaatca ggagtatgag tcaaatcatt tggaaaaatg aaaatacgtt   1079580
catcttggga tagactttcc aaggttctgt ctaaaagagg attgcttagt ttaggatatt   1079640
cttcaacaaa tttttcttta ataatcttgt gttgattatc agtaatccgc atcatcgttt   1079700
tcatcgcctt cattgtcatc agctactgcc tgatcttttt gctcattatt tgtcagatca   1079760
aatgcttttt tcaaagtttc caaagtttca acctcatcat aagaacctcg caagtagtct   1079820
tctaggagag gcttaatata atcagaccag agtaattcat agtcaaaatc tacatccttc   1079880
aacttaagaa aataacttgg tccaatatga taatgactgt ttaattcctg aatattttcg   1079940
atagcagcgt tcaagtttct tagacgaatt tttgcttctt ctgcatggat attcaactct   1080000
ttatccaaca tgccagcttg accctcgaca gtaacttcaa caaaacgaaa acgacgacgc   1080060
atagcaaaat caaaggtatc cactgaacga tcaatatcat tcatagttcc gatgatgtaa   1080120
acattttcgg ggatatagaa cttttcatca gtttcgtgta gatttgcata ttgggtagaa   1080180
acacttcctt tttcaccacg atagccgggg tcgatagaga aaaagagttc gccaaaaatc   1080240
ttagaaatct ccccacgatt gatctcatcg atgatgaaga caaaattctt atcagtatca   1080300
atttctgttg gggaaacata gtctttcaaa ccaaatctct ttctcaatgt ttctaggaca   1080360
gtttttccac cacttttgta gtattcttgc ttattataat ttttatcttt atacaactcg   1080420
taaacatatt tgctaggtag tgaccatcct ggaacaccac tatcataatt tactgacaaa   1080480
ttttgtctac tattaacaga taagtaagat gtttttgtta tatattcttt ttcttcagca   1080540
acatttatat attctaagta agaatcccaa gcctcatcaa aattatcttg tcctccaatc   1080600
aattgggttt cttttgcttt ctgacaaaaa tctttaaaaa taccgtcctg tagcctaaac   1080660
tcaatagctc catccccatt tgatactggt cttaaacctt ctacaaaatc cgtataatca   1080720
tatgatgggt gaaattgtac aaatccgatt tgatcttcgt tgccatccgt taattcttta   1080780
gcaatttctt tagcaagata agtttttccc gtgccaggag caccgcggag gatgaggttt   1080840
ggagacttta atagagattg agttaattga tgacgaaaat tgtttgatga atccattgta   1080900
ctattgtctt ccttattttc cataaaaagc ttagaatact caaaaagcat agttcctaat   1080960
ttcgatggct ccaactcagg ataagttttg gacaccagtt caattatttt atgattttgc   1081020
agataaggtc caccttgatt tgtctgagaa acaaagtggt tccaaaattc tttctgacta   1081080
ttaatattta caccaaagaa aggatctccc tcagtataga tacaaagtaa ttttgtcacc   1081140
atagcagaac gaccaataaa ttcatttgtt gatcttttca tatcaaaaat aggattttca   1081200
aagttaaaac gaataccttc tttgataatt tcatacaaat ctgattttaa ttttgaaaat   1081260
cgctgatcca actctgaaat ctcattatta gcttgatctt tatatttgtt tgttttttta   1081320
ttccaataaa taccaaattt tgaagctgag ccaccagaaa ttccaagaaa tagatttttg   1081380
tattttccct tctcaagagc gtagcataaa gacttatttt gctgtccctt tcctattaca   1081440
tattcatcga ttgacattgt taaaatccta tccaaaggcc attcctggag aaactcttct   1081500
tttaatttat cattaaactt ttcaccaaca gttgccttat ttaataactc ttctttattt   1081560
agactatacc atttataaaa atcttctaaa ctaacttttc ttttattcat caatctaact   1081620
ccttttacta atgatgttta aatattggca ttacttatta acatatattt tctacataga   1081680
ataccatatc ctatagaaaa agaaaagaaa ttctaaacaa aagcccagtg ttaggagctt   1081740
taatatctca taacactaga cttcttctct atcctaataa tactcaacct gacggtagtc   1081800
ccatgagtta aaagtatctg acaggtgcat catgatttta tcaatgtcaa gccctttacg   1081860
gatcacaact ggagctggtg aagttgaacg tgctcctcct tgttctggga tgagtttgcc   1081920
gtccttatcg accatagaca ccattacacc ttgctcatag cgagtttcaa tcgttttgtc   1081980
attgaagcag atgaggcgta gaccatttta ccttcttccc aaagcttggc agccaattgt   1082040
tcacctgctt ttccaaactt gataacaaaa cagctagtac cacgtacatc agtaataagt   1082100
tcttcacggc catccccgta tgctttgagt ttttcaaagg cttctggttt ccaaggaagg   1082160
atacaaccaa gaagaatatc ttcatcccaa tgtttttagt agaatgcttc aatttctggg   1082220
ttgagttgcg ctaaagcgca aagttcatcc atgctaccgc agagaacaac acctggtttg   1082280
ttacgcttac gttctttggc tgcgaactta cgctcaagtc ctgccttgtc actggtcatg   1082340
ataatgtaac caactttagt agggcaaacg atacatccgc cctcaccttt taaaatgtcg   1082400
tagccttctt gtgaatgtgt tttgtcataa ttttataatg tgttgaatcc agaatagtcc   1082460
actgtagttt ctaaaaaatt gctggaaatg gatgttaagc tccaattcat ttgtttacat   1082520
cttatttcag tttactatat ctccttttct attttttcta atcctgccag taggctggtc   1082580
gttgtttttc ataagcagca atcaactctt catactgcaa ggtaataccg atatcatcca   1082640
aactatttag gagtttatgt ttccactcgc tatctatctc gaaggtgaat tcttcaactg   1082700
gtgagatgat tttttgttgt tccaagtcca cagttacctg gtcggttggt tttagctggg   1082760
ctagtttctc tctaacctct ctaggctgaa cgattggcaa catgccatta ttgagttcat   1082820
tattgtaatg aatgtcaccg aaagatcctg caatcacgac cttaaaacca tagtccgcta   1082880
gagcccaagc agcgtattcc ctcgaagacc ctgccatcca ttacctccaa ataaaatata   1082940
aggctactag tgtggtcacc atcccaagaa accaaactat tttaaagtac cattttcgag   1083000
tcttgtggtg aaagatgatt cctgctagcc aggcaccaaa accaccaaaa gtaaaggcta   1083060
aaataagtaa gattttctca gggatgcgcc aaactcttct ccttgcctta gatttgtcaa   1083120
taccataaat caagaaaatg atgacattcc aaatcaaaag gactagagta attttttcgt   1083180
ctaacttcat aaccttgcaa taatagcttc cgtcatttcc tttgttgaag cctgacctcc   1083240
tatatctctc gttaaaattc ctgccgccag acttgtctca acagcacgtt tgatacgctc   1083300
tgcatcctca taacgtccga aactatctct caacatcatg gaaactgata aaatcatgga   1083360
aataggattg gcaattcctt gacctgcaat atcaggtgct gaaccgtgaa taggttcata   1083420
gagacttggt ccattttcag aatgactggc tgatggcata accccaagtg taccagataa   1083480
gacgcttgat tcatcagata aaatatctcc aaaaagattc tccgttacaa taacatcaaa   1083540
cttagcagga ttggtaatca taagcatagc agctgagtct accagctgat gttccaaggt   1083600
tacatctggg aaatcctgtg cgacttcctc agctactttc cgccagagtt ttgaggtcgc   1083660
tagaacattt tgcttatcga tactagtaac gatttttctg cgatttcttg caatttcaaa   1083720
ggctttgcga ataatccgct ccacttcctc atagctatag tcgttgatat cacgcgcatt   1083780
gcgctcttca agaatatgat atccaaagta aatcccgcct gtcaattcac gcaccacgac   1083840
aaagtctaca ccagcaattc gttccagttt gagtggtgac aaatgcttga gactgtcaaa   1083900
gatttttaca ggacgaatat tagcgtaaag attgagttcc ttacggagag ccatcaggcc   1083960
ttgttcaggg cgaaccactg ctccatcata ctgaggacta ccgatagcta ctagtaggat   1084020
agcatctgct tccctacttg ccttaagggt ttcatcaggt aagggaggtc atgctgcatc   1084080
aatatctgca cctccgaacg gtcgtctgtc aatctcatag tcaaaacctg ttttttcagc   1084140
tagagcctcc agaacttcta aaccaacctc catgatttct gggccaattc cgtctcctgc   1084200
tagagctact attttctttg ccatagcctt ctcctttaca cactaggcat atcgtggtaa   1084260
gaaacactgc gtcccatctc acctgcattc tctttttgaa caaaggtatt agcgtttata   1084320
tagacaatag cagaagcctt caacacatca aaatcaagcc ctgctgcatt aaagatggtt   1084380
tctgtatctc tgttttcaac agtgaccaaa acccgatcct gggtatcgat tccatctgtt   1084440
accgcatcga tagtgtagga caccaaacga acagattggt taaagaactt atcgatagca   1084500
ttaaagattg cttcaacgga accttgccct gtcgcattaa attcgacttt ctcaccatcc   1084560
atattggcta ggctaacgag cgcttcaatg tcattatctg catgagtttg aagttgtaaa   1084620
tcatcaaagt ggaagccttc tggattttca accatggttc cagctaccaa agctcgaata   1084680
tctgcatctg tgatttcttg cttcttatcg accagtgcct tgaacttagc aaagagtggt   1084740
ttgatatcct cttctgtaaa atctagggcc aattctctca gtttctcaac aaaagcatgg   1084800
cgaccagata attttccaag cagaatctta acaccaacca attcaggtgt gatgatctca   1084860
taagtgagag gatttttaag gactccatct tggtgaatac cagattcgtg ggagaaggta   1084920
ttgccaccaa cgacggcttt gtttttagga actggaatac cagagaagcg agaaaccatt   1084980
tctgacgtat tgatggtctc atttaggaca atactggttt ctacttggta gtaatcttgg   1085040
cgaatattga gagccactgc aatttcttcc aaagcagcat tttcagctcg ctccctaata   1085100
ccattgatag tcccttcaac acgtcctgca ccattcttga cagcagcaag gctatttgcc   1085160
actgccattc cgaggtcatc atgacagtga ggcgaataga tgatctgacg atccgtcttg   1085220
acattctcaa tcaggtattt gaagatggca ccatattcct ctagtgtggt aaatcctata   1085280
ttttctaaaa atctcttcag taaagaatat ttagctaatt gaaagttcat gaaaattatt   1085340
aaaatatttc attttttaga ggttaagttc caactttttt ctatcaattc cagtacttct   1085400
tcatctgata aagtatcatc aagggacaca ctaatccagt agcgcttgct catatggaag   1085460
gctggataaa tccccttttg tgaaagcaaa ttagctactt ggtcatgctt gaggttgact   1085520
gcttccactt gtccttctct gcccttttcc agcttattcc aagagatttt catcaagacg   1085580
gcataccact tttgattgcc ttcatggcgc aatacagctg tatcaggcga tttttcccac   1085640
agatactcca actggtttcc atacttttcc tgaacttgag tcatgatacg cttagtctga   1085700
tgacagataa aatcttgcac atcaaaacaa gccttccgaa tctggtaaag aatctccaga   1085760
caagcctcac ggacatttcc gacaaaactt cccctcatgc tttccatata aacgtgagga   1085820
tagaggtcac cagtctcttg gtcaaagact tgaaagttca cattatcagc agtgatggac   1085880
acagtcatga caaagtcacc ttgcaaaatc tggcaactat atgtccagac ttcgctattt   1085940
tctataaaac cataatcatg agccttttct tgattaaatt gataggattt aaaaatttca   1086000
aacataagtg aaaactgcta cccaaagcta gcagttcctt tctatttttt aaaaaacaac   1086060
cttagtacca tgcaattgtg ttacccccac ctggtcgata aaggtttgac ggttttcaag   1086120
gtcaatcccc ccacctggta gaatttcaat tttaccttta gcgtactcca aaattctgtg   1086180
atagtgaaca aaacgttttt ctaaggagtc gccagacaca ccagcacgag ttaggatacg   1086240
agtgacaccg gcttgactga gccagtcaat agcttccgct tgatcttcat cacttagttc   1086300
atcaaaggcc atgtgaaaga caatttccat tccttttgat gcagcaatta acttttccag   1086360
attaggctta tccaactttt tatcagcagt taaagctcca aatacaaccc cttgacttcc   1086420
agcctgagca gtcaaacgaa tgtcttctag catgatagca atttctaggt cattatagac   1086480
aaagtcacca ccacgtggcc gaatcatggt catgatggtt gtatcgtagt tagctgccag   1086540
ttcaaccgct gccttagtca ctccatagct gggtgttgtc ccaccaactg ctagattatc   1086600
acagagttca atccgacgag ctccagcctg catcgctttt tcaagtaaag tcacattttc   1086660
agcacaaaat tcgtaaatca tttgattctc cttgaatatt acttcaattt tattatatca   1086720
tattgttatg aatatgcttt caattttatc aaggcaaata actactgttt taactattct   1086780
ttgtctggaa tgaccttgaa gagataataa gtaataaaga tggtcaaagc acccagaccg   1086840
attttgactg gtaaaagagg tgcaaaataa atagaaattc ccatcaagac gtagatagag   1086900
acgatgattt ttttctttcg ttcacgcgca atagacttgg tctcacgaaa atcagctaca   1086960
tatgcttgat agagcttggt atgataaagc caatcttcga atcgcttgga acttctggag   1087020
aaacaagcaa tagacaacaa aaggaaaggt gttgtaggca acaagggtaa aacaacccca   1087080
acaatagcca aggtcagcga taaaaaacca ataattagat agataatacg cataacttct   1087140
cctagttaat actcttcgaa aatctcttca aaccaggtca gcttccatct tcaacctcaa   1087200
agtagtgctt tgagcaacct gcgactagct ttctaatttg ctctttgatt ctcattgagt   1087260
ataaaataat cttcttctag tttcgcataa aatgatgttt tttgtcaagt tctaaccaaa   1087320
aggagcctga aatttacttt cgggcccctc ctcttattta atcttttcgg ttctataata   1087380
tttgtagtgg gtaaatccac tatagatatt atggagccta ttttattgta gaaaaaaagt   1087440
cccatatgac ctataatgaa aagcgacaaa acaactcatt agaaagaatc atatggaaca   1087500
attacatttt atcacaaaat tactagacat taaagaccct aatatccaga ttttagacat   1087560
catcaataag gatacacaca aggaaatcat cgccaaactg gactacgacg ccccatcttg   1087620
ccctgagtgc ggaaaccaat tgaagaaata tgactttcaa aaaccttcta aaattcctta   1087680
tcttgaaacg actggtatgc ctactagaat tctccttaga aagcgtcgat tcaagtgcta   1087740
tcactgttca aaaatgatgg tcgctgaaac ttctatcgtc aagaagaatc accaaatccc   1087800
tcgtatcatc aaccaaaaaa ttgctcaaaa gttaattgaa aagatttcta tgactgatat   1087860
tgcccatcag ctttccatct caacttcaac tgttattcgt aagctcaatg actttcactt   1087920
taaacatgat ttttcttgtc ttcctgagat tatgtcttgg gatgagtatg cttttacaaa   1087980
gggaaagatg agcttcattg cgcaagattt taacaatctc aatatcatca ctgttcttga   1088040
gggaagaaca caagctatca ttcgaaatca ctttcttaaa tatgatagag ccgtccgatg   1088100
tcgcgtcaaa attattacta tggatatgtt tagtccttac tatgacttag ctagacaact   1088160
tttcccatgt gctaaaatcg tgttggatcg ctttcacatt gtacaacatc ttagccgtgc   1088220
tatgagtcgt gtgcgtgttc aaatcatgaa tcaattggat cgaaagtctc atgaatacaa   1088280
ggctatcaag cgctactgga agctcataca acaggatagt cgtaaactca gcgataaaca   1088340
tttttatcgc cctacttttc gtatgcattt aaccaataaa gagattttaa acaagctttt   1088400
gagctattca caagacttga aacatcacta tcagctctat caactcttgc tgtttcactt   1088460
tcagaataag gaaccggaga aatttttcgg actcattgag gacaatctaa agcaggttca   1088520
tcctcttttt cagactgtct ttaaaacctt tctaaaggac aaagagaaaa tcgtcaacgc   1088580
ccttcaacta cactattcta acgccaaatt ggaagcgacc aataatctca tcaaacttat   1088640
caagcgcaat gcctttggtt ttcggaactt tgaaaacttc aaaaaacgga tttttatcgc   1088700
tctgaatatc aaaaaagaaa ggacaaaatt tgtcctttct cgagcttagc tgacttcaac   1088760
ccactacagt tgacaaagag ccatcttttc ttcctcgtag tcgcctttgc tacaaacaac   1088820
ctgcttgcca ccaccacgga cttttttctc catgaggaag ttgccacatt ttggacagtc   1088880
acgaccaaca ggcttgtccc aagaggtaaa ttcacattct ggatagcgat tgcaaccata   1088940
gaataggcga ttacgcttgg tttttcgctc aataatttgt ccctgatgac agcttggaca   1089000
ctcaacacca atctctttca cgattgcttg ggtatgacgg caatctggga aattgctaca   1089060
agcgtagaat ttaccaaaac gaccaagttt aatgaccatt ggactgccac acacttcaca   1089120
gtcaaatcca gctggttcat ccttaatctg gattttttcc atttcttctt cagccttggc   1089180
aacttcttta gagaatggtt tgtaaaaggc atcaatgacc cgtcgccact gctcttttcc   1089240
aacttcgaca tcatccagtt taccttccat ttcagctgtg aaggtcacgt ttacgatatc   1089300
tgggaaatat tcaacgatga gcttattgac aatttctccc aactctgtcg gttcaaaacg   1089360
tttggctgcc aggcgaacat aataacgttt ctgaatggtt tcaatggttg gcgcgtaggt   1089420
tgatggacgt ccaaccccat tttcctctaa ggttttaatc agtgttgctt cagaataacg   1089480
ggcaggcggt tgggtgaaat gttgctctgg tttgctattg acctgtttga ccacatctcc   1089540
aacaaccatg tccggtaaca tcttattctt gtcagaatca ttataaatgg caagataacc   1089600
atcaaactta acctgactac cattggcagc aaattgaacc cctttttgag acaatttaac   1089660
agccatggta tcaaaaacgg ccgctgtcat ctggctagcc acaaaacgat tccagataag   1089720
ggtatatagc ttaagctgat ccttgtccag atacttagcg atgctttctg gtgtattaaa   1089780
gacacttgac ggacgaatag cctcatgggc atcctgagca cctgatgcgt ttttgacctt   1089840
gctaccgtgc ttagaatact tgctaccaaa acgatccgta atgaagcttg ccgcctcatt   1089900
ttgcgctaca ggactgatac gagtcgaatc ggtacgcata taggtaatca aaccttgaac   1089960
accagaaccg atattaattc cttcatagag ctgttgggca accatcatgg tttttcgagt   1090020
acggaaattg attttattgg cagcatccat ctgcatagat gaagtggtat agggtaaagg   1090080
agcattgcgc ttgcgctctt tcttatccac ctgatctact gaaaagtctt tactcgtcag   1090140
acgagacaag acttccttga cttcgttatt gctggtcagt ttcatctttt taccatctac   1090200
tccatagaag gaagcatgaa attgtttggt tcccttttta aagacagcat caactgtcca   1090260
gtattcttct ggctggaagg cattgatttc attttcacgg tcaatgatga gtttaagggc   1090320
aatggactga acgcgacctg ctgacaagcc cttcttgacc ttcttccaca aaataggcga   1090380
aatcgaatac cctaccaagc gatccaagat ccgacgagct tgttgggcat cgaccaagtc   1090440
catatcgatc ttacgaggtt ctttaaaagc atttttgact gcatccttgg tgatttcatt   1090500
gaagaccaca cggttggcat cattttcatc caagttgaga atatgggcca aatgccaaga   1090560
aatcgcttct ccttcacggt ccgggtcact cgcgagaaaa actttattag cttttttagc   1090620
ttcttttttc aagtcattga taagagggcc ttttcctcgg atattaatat attgcggttc   1090680
ataattattt tcaatatcga cggacatact ggatttcttc aaatcacgga tatgcccgac   1090740
actggctaaa accttgtagt ttctgcctag atatttttca atcgtcttgg ccttagcagg   1090800
cgactccacg atgactagat tttttttaac tgttgatttt ttcttttttg ttgccgtagc   1090860
cacagtatca caccttttca aagtaataaa ctttataaag tgtaaaccat tttttgaacc   1090920
ctgtcaagac ttagctacta taatagaaga aaagttttat acttaaaacc tcagtcttcc   1090980
tttgatatac atagaagact cacgagagaa accagctatt ctcaagaaat tattgctcct   1091040
cagactctgt atcaaattta ttggctttct ccttttcttt tgcttcctta tccttgatat   1091100
actggaagaa atactccacc agctcttcct tactaagttg ttctgaatca gacaattgtg   1091160
aaacttgaac agaaacatca cttaaaccat agtcacctct cttacttgaa atcatatcga   1091220
gttcttcttc tgtcaaataa tttcctgaaa tggttagctt tagggtatga gtctttttag   1091280
aataggtttt tttcaaaata ttatacccct gaaactgctc tgatataaat ttcttaaggg   1091340
actctttttt caacgtttct ctcactaaag tcgttgcaga gatgaaactc ggaatcatca   1091400
gcaaaacagc aactagaagc aaaatcctac gcattttaga gtcttcttca ttatctttaa   1091460
aataatgttt cttaaccatc atcaacctaa cacctatata agtcgcaatg acaataaagc   1091520
tacaattgat gaggaatagg taagaggagc ctatgataaa ttttagatta gcagaagcaa   1091580
tagcataacc tactgtacaa agaggaggca tcaaggcggt tgcaatagca acaccaggaa   1091640
caatattatt ggtctctttt ttcctagcac caatgatacc tgctatccct cctacaaaag   1091700
caatgagaac atcccaaata gtcggagagg ttctagcaac aatctccgaa ctagcatacg   1091760
aaatgggaga aagataaaaa taaagtgttg aagctattag actggcaaga atttgaatag   1091820
ctaatatttt aaaagatttt cttaacaatt taaaatcaaa tatagctaga gagagcccca   1091880
ctcccagaat aggtgtcatc aaaggagaga ttaacatggc tccaataatc acgggagtcg   1091940
aatccatatt taatccgata gaggcgataa gcatggcaca tagtaaaatc gctaaatcac   1092000
ttctggaaag ttctaattct tcatatattt tatttctaaa ttctatcaac gaatacagtt   1092060
tattatttgt cacaaatatc ttcctttccc agctaactag tcgctaaaat cctaacaaac   1092120
tcaatacttt agtagtctga tatgccaatc tcacgagctc tttttatcat tttccataat   1092180
atcctgactc aaatgtctac tgatatctct catcagtttc atttctagta aatgaaaatc   1092240
aaactcggaa gctaaccgta gcttgctcaa aacacagcaa ggcaaagctg agctgacgta   1092300
tttgaagaga ttttcgaaaa gtatcatcat ctatttcaga ccatttttta taataaccat   1092360
tttattttta tttgtcaagg tctttgaatt ctttcttaaa caagccttgt aatctctact   1092420
tttgaagaat ttatttttcc ttactgacaa gatttgagac ggtaggaatc attgaacata   1092480
acctagccaa catcaatcac aatcatttct cctttctcaa ttacactaaa ttatagtgta   1092540
attgaatcta taacagtaca ccttggctgc taaaatattt ctataaatta atttgacttt   1092600
cctgatagag ttgttcacat cttatttcaa ttcactatac tttcccttat actcaatgaa   1092660
aatcaaagcg caaactagga agctagccac aggttgctca aagcactgct ttgaggttgt   1092720
agataagact gacgaagtcg ctcaaaatac tgttttgagg ttgcagatgg aagctgacgt   1092780
agtttgaaga gattttcgaa gagtattata tgagaaaaat cctctactct actaatccac   1092840
ttagaaaaaa cgcatattat caagtgttaa aaacttgcta atatgcgttt tattatggaa   1092900
atgttgggtt cattttctct taaaattgat tttttcttag aattctagct taggtcattt   1092960
ttaaaattca aattccgcaa gaacatcttg cccactggtg accaattttg ctccttcttg   1093020
aatcaaatga tggcaaccgt ctgatagtcc atctaaaatg ctaccaggaa tagcaaagac   1093080
atcgcgtcct tcttccattg ctcgctcaca cgtaatgaga ctacctgaac gcatcttagc   1093140
ctctgctaca atcacaccac gacaaagtcc agcaatgatg cgattacggg caggaaaatg   1093200
aaatttcaga ggttgttcac caggtccata ttcacttaga accagatggt cattgccgat   1093260
gtagtcttgc aagcgtttat tggctttagg ataaaacaca tccagtcctg ttccaatcac   1093320
tgcaatggtt tttccgccat tctgaagagc tgccatatga gctgctgtgt caatgccctt   1093380
ggccagacca ctgacaataa ccagttcatt ttccaagcct tgaatgactt tttcaactga   1093440
cttagctccc tgtttgctac aagcacgact gcccacgacc gctaccttcg ggaatttcag   1093500
gaggtcaaga tttcccttgt aaaataaaag tacaggcgca tcatatattt cactcaaatc   1093560
ccaaggataa cagtcatcta aaatagagaa agatggaaat ttttgaaact ctttcgacaa   1093620
atgcgcatcg tctatctgaa aataacgttc cataaaaacg gctggattac ggcaacctga   1093680
gatatctgca atatcaccca acaaaagctc ctgatcaaca ttttcaccgt attctagcac   1093740
tttcaaaatc tgttgattgg tcaaacctga tttttttaac ttatagattt catagtttgt   1093800
gattttcata aataactcca tttctttttc tactcatcta tctattcgta aaagttcgta   1093860
aaaaatcaaa aaacatccga ctattttgtc agatgttgga atctttaatt ttcgttttta   1093920
agaatttctt ctaatttacg atagtcttgg acactatcga tctcataaat gctattgcct   1093980
tctaattctt caacatagac atctagctct ttgatattat ccttaaccat attgtcccaa   1094040
tagagatcaa caaattcacc acttacataa gccttgtcga taaagctgac aatcttttct   1094100
gcagttggag catcccagaa ggatacacca ctaaggatgc gacctgcctt gctatcaaca   1094160
ataatgtctt gaaccttgta gtcatctcca taaaccaaga accattcgtt ggtacaatct   1094220
tcacgataaa cactaaaata agtcgaacgt gtcaaatcat tgcggaacat atttttaaag   1094280
agataattgt cagcatcaat aacatagctg ttggccaatt cttcttttac aagatagaga   1094340
gagtaaaagt tattgtagtc agcgtattta tcattgaaaa cgagacgaac accgtatttc   1094400
tctttcaagt aatcgaattg ttctttaaga taaccaacaa tgatgatgat gtcattgatt   1094460
cctttttctt tgagaaactc aatttggtac tcaatcaaag gtttttgatt aacctgaacc   1094520
aaggctttag gggtattttc agtcatagga cgcaagcgag ttcccaatcc cgctgctaag   1094580
ataatggctt tcacacgaat ctcctttatt ctttaataat aatataaact ccagcaatga   1094640
cgacaagtga cgtcataatg gtcagcatat ctagcggtgc acccaagaaa acaactgcaa   1094700
acaagaccgt ccatactaca tagctcacgt tcaagcctgt agccttggct ggttgcaagc   1094760
gattgatagc gatataataa gccaagtagg aaatcatatc aaaggctgca aaaacaatca   1094820
tgagacctag caattgtcca ttggctactg cagtaaatga ctgatgagag aagagcacaa   1094880
tcacaagata ggacaagaac gaagttactt gacggattaa gagggcttcg atttcactca   1094940
attcactttc catggcaaaa gagctaagaa cactctcact tccccatgca atagcacaaa   1095000
ccaaagcaca aagaatccca atgtagaaag aattaacctg ttcaacctta taggtctgag   1095060
caataatccc tccaataatc aagacaatcc caaatacagt atttttcgaa atcttgtgct   1095120
tcaaaaagaa gaaagccaat agaactgaaa tcgcagggta aatagccgat acagatgaag   1095180
ctaaagaact tccgatatac ttaactgcat aaagattggc ctgcataccg atagggcctg   1095240
ctagcaaggc tccgatgata acactgacat tgcgaatatt taagaaaatt gagaggcgaa   1095300
ctttcccttc ttttaccaag agaaaagcta gtaagataaa gatgctcaaa aaatcatgag   1095360
ttgcagccac cacaaagggt gacaaatctg taaaaatcga aaagatataa gcactaaccg   1095420
ttagacccaa gccccagaaa atacctgaga gaaggccaaa aggaactccg tttttacttt   1095480
tcatctgaac ctccataaga agccaaacct ttaatagctc tttggtaacg attcacacca   1095540
tagtcaccaa aatcttcacc ttgctcttcc ttatagacag tccatagact ccaaatagta   1095600
tcttgtaaaa ttttataaat agcaatcttt tcatgagaaa ccggtgtttg gtcactctca   1095660
tagtgagata agaaagtttc ttcctcttgg gaagtgaatt cagactctaa aaagagggca   1095720
gccaaatccc acattggatc attcattgat gaatattccc agtcaatcaa ataaagtcgt   1095780
ccttgaggtg attcgataaa gttttcaggc accaaatcga tatgacaaga ttttctgtca   1095840
acacctaagt cagccagtct tttctctaag gagaagactg catttctaac agattcatag   1095900
ttggcataag gaatttgttc ttcaatcaag gattcgtatt ttttgatttc ttcaaaagga   1095960
gcaaattctc ctcttaattc cttagcagac gtatgaatag tttgtaatat tggagtaatt   1096020
ttgtcgaact tggtcttgat tgacgttgaa tcaagcgtaa tcgcagattc gatatactca   1096080
tttactttga taccagcttc aatatcaaaa agataatttt ttacatctaa gcctaaatcc   1096140
tttagtagtt caagattgta cttttcatct tgtcgattga taagcttttc tgtcccttta   1096200
ccaaagaatt taacaatgta ttgcttattt gttgttttgg ccaaatagtt ttgattggtc   1096260
attccaccca gttgttcaac actgaggact tcctcttctt gactaagtaa ggaagaaatt   1096320
ttttctttaa tgattttctc cacaattaac ctccagtact tatacttccc acttaaacac   1096380
tgttttaaag gctgtgttta aatcggttgc aaagacacga tgaatatctt taatttctct   1096440
tacaggttct tctagataaa ggatattttt aagacgattg gcaaatttct tgacttccat   1096500
catttggata gcattttcaa aatcaatgcg accagaacga gatgacccaa ccaaaatcaa   1096560
gcccttttct aaggcatcgc gagtattgag attgacttta tattcgctaa ctcccatcat   1096620
gagaatcgtt ccctgaggac gaatgtagcg aatcaagtca ttaatagctg gtccagtacc   1096680
atcaccacca caacattcaa aagcatggtc aaaggccaaa tcttcaggaa tattatccgt   1096740
aatatagcat tctttggcaa atgagaagag ttccaacttt tcccaatgac gaccaataac   1096800
cacaatctct gcttctggca aagtatagtt gataatattg gcaaccacaa aagctaaact   1096860
tccatctcca ataacggcga tccgctcccg cttgctatga gcaagagtca atagacgatt   1096920
catagcgtgc atgcccacac tgacaaactc tgtaatggct gcaaccgtat cttcaatagc   1096980
atcataagcc accacacgat ctttagggag agaaacaaac tctctcataa agccatcaaa   1097040
tccactagac aagaaatggg tccctgtcat gtagttttca tagaattctt catcactctg   1097100
cataggagac tgattgggaa tcatgacaac tttttgacca acctcgtagg ttccggtcgg   1097160
gtcagaaatg acggttccac atgactcgtg aatcattgcc attggaagct ttttattcaa   1097220
aatcttggga tcacgttttc cctgatagta acgctgatcc gcatgacaga cagccatgta   1097280
gttgggacgg ataaggatat gattctcttg gtcaatagcc tcttcctgat atttgacatt   1097340
gataaactta ggcttagtta gttgataaat ttgattaatc attttactag tctttctcaa   1097400
tcatactttt tgcaatcttc aaatctgtta cggttgtaat cttcagattt gagtattcac   1097460
ctttggccaa agccacatct tttcctttga tcacaaagat tttacatgca tctgtcaaga   1097520
tttccttctc ttcatcagaa agagatccat aaaggtccat gaagtccttg caacggaatg   1097580
tttgaggtgt ttgtccttga taaaggtgag cacgatttgg aatatctgta ataaattgac   1097640
cattggtact ttcaacgata gtatcaaccg cttctaccac tgtgtccact gcgtcatgat   1097700
tttgggcaag ttggatattg tcctgaatca tgcgaagtgt aataaatgga cgaacagaat   1097760
cgtgggtaac aacgatatcc tctggagtaa gcggacgata agcatcaatg gcttcaatga   1097820
tgttcttaat acttgtattg cggtcagcac caccctttgt aatgatgata cgttccttat   1097880
aaagaggaag atatttatct acaagatctt ctgcatgaga aacccagtct ccatgaacac   1097940
caactacaat tttttcaata cttggctcca agacaaattt ttcaattgta tgaatcaaaa   1098000
taggtcgatc acctagctct aaaaattgtt ttggcaagtt actgatcccc atgcgtgtgc   1098060
cagttccacc ggcaagaatt cctgcataaa tcatctattt tctcctttgt cttactaaaa   1098120
aaacttattc tctctattat accacaatct agtcctatca taaaagaaat actggtcctc   1098180
cccttctaga ataggagaat tatgcagttc tattattcaa agaaactagt ccatttctag   1098240
taatgactag gaattctgta gcaattacta ataaatggct gcgaaatttt agagtccttc   1098300
agaataatat actttcctta aagaaaactt aaaacttaag atttgaaact tcaaagtgat   1098360
tacttgactt actgcccttc atttcttatt agctaacttt atgatataat gaaaaacgag   1098420
gtaaattgaa tgaaaagtat aaaattaaat gctctatctt acatgggaat tcgtgtcttg   1098480
aatattattt ttcccatcct aactggaacc tatgtcgcgc gtgtcttgga ccgaactgac   1098540
tatggttact tcaactcagt cgacactatt ttgtcatttt tcttgccctt tgcaacttat   1098600
ggtgtctata actacggttt aagggctatc agtaatgtca aggataacaa aaaagatctt   1098660
aacagaacct tttctagtct tttttatttg tgcatcgctt gtacgatttt gaccactgct   1098720
gtctatatcc tagcctatcc tctcttcttt actgataatc caatcgtcaa aaaggtctac   1098780
cttgttatgg ggattcaact cattgcccag attttttcaa tcgaatgggt caatgaagct   1098840
ctggaaaatt acagttttct cttttacaaa actgccttca tccgtatcct gatgctggtc   1098900
tctattttct tatttgttaa aaatgaacac gatattgttg tctatacact tgtgatgagt   1098960
ttatcgacgc tgattaacta cctgattagt tatttttgga ttaaaagaga catcaaactt   1099020
gttaaaattc acctaagtga ttttaaacca ctctttctcc ctctgacagc catgttagtc   1099080
tttgccaatg ccaatatgct cttcactttt ttagatcgcc tcttcctcgt taaaacaggg   1099140
attgatgtca acgttagtta ctataccata gctcagcgaa ttgtgaccgt tatagctggg   1099200
gttgtaacag gtgcaattgg agtgagtgtg cctcgtctca gttactatct ggggaaagga   1099260
gacaaagaag cctatgtttc tctggttaat agaggtagtc gaatctttaa cttctttatc   1099320
attccactga gttttggact catggtttta ggaccaaatg ccatcctact ttacggtagt   1099380
gaaaaatata tcggaggcgg catcttgacc tctctcttcg cttttcgtac gattatcctg   1099440
gccttagata ccattcttgg ttcccaaatt ctctttacca atggctatga aaaacgtatc   1099500
acagtctata cagtctttgc tgggctactc aatttgggct tgaatagtct cctttttttc   1099560
aaccatatcg tggctcctga atactactta ctgacaacta tgctatcaga gacttctcta   1099620
cttgttttct atatcatttt catccataga aaacaactca tccacttggg acatatcttt   1099680
agctatactg ttcgatactc tctcttttca ctttcctttg tagcaattta tttcctgatt   1099740
aatttcgtgt atcctgtaga tatggtcatt aatttgccat ttttgattaa tactggtttg   1099800
attgtcttgc tatcagctat ctcttatatt agtctacttg tcttcacaaa agatagcatt   1099860
ttctatgaat ttttaaacca tgtcctagcc ttaaaaaata aatttaaaaa atcataggag   1099920
tttaaaatga aacaactaac cgttgaagat gccaaacaaa ttgaattaga aattttggat   1099980
tatattgata ctctctgtaa aaagcacaat atcaactata ttattaacta cggtactctg   1100040
attggggcgg ttcgacatga gggctttatc ccttgggacg acgatattga tctgtccatg   1100100
cctagagaag actaccaacg atttattaac atttttcaaa aggaaaaaag caagtataag   1100160
ctcctatcct tagaaactga taagaactac tttaacaact ttatcaagat aaccgacagt   1100220
acgactaaaa ttattgatac tcgaaataca aaaacctatg agtctggtat ctttatcgat   1100280
attttcccta tagatcgctt tgatgatcct aaggtcattg atacttgtta taaactggaa   1100340
agcttcaaac tgctgtcttt cagtaaacat aaaaatattg tctataagga tagcctttta   1100400
aaagattgga tacgaacagc cttctggtta ctccttcgac cggtttctcc tcgttatttt   1100460
gcaaataaaa tcgagaaaga aattcaaaaa tatagtcgtg aaaatgggca atatatggct   1100520
tttatccctt caaaatttaa ggaaaaggaa gtcttcccaa gtggtacctt tgataaaaca   1100580
atcgatttac cctttgagaa tttaagcctt cctgcacctg aaaaatttga tactattttg   1100640
acacaatttt atggagatta tatgacccta ccaccagaag aaaaacgctt ctacagtcat   1100700
gaatttcacg cttataaatt ggaggattag gatgcaatat ttagaaaaaa aagaaattaa   1100760
agaaattcaa ctagccctgc tggactatat tgatgagact tgtaagaaac atgatattcc   1100820
ttattttctc agttatggaa ccatgcttgg agccatccgc cacaaaggta tgattccttg   1100880
ggatgatgat attgatattt ccctttatcg tgaggattat gagcgtttac tgaagattat   1100940
tgaagaagaa aatcaccctc gctacaaggt tctttcctac gatacatctt cttggtactt   1101000
ccataatttc gcatcgattt tggacacttc tactgttata gaagaccatg ttaagtacaa   1101060
gcgtcatgat accagccttt tcatcgatgt cttcccaatt gatcgattta cagacttgag   1101120
cattgtcgac aagagctata agtatgtggc tcttcgtcaa ctagcttata tcaaaaaatc   1101180
acgagcagtt cacggtgata gcaaactaaa agattttctt agattatgta gctggtacgc   1101240
tctccgattt gtcaatcctc gctactttta caagaaaatt gatcaactag tcaaaaatgc   1101300
tgtaaccaac actcctcaat atgaaggagg agttgggatc ggtaaggaag ggatgaaaga   1101360
aatcttccca gttgatacct ttaaagaact gattttaact gagtttgagg gccgtatgtt   1101420
gcctgttccc aaaaaatatg accaattttt aacccagatg tatggcgatt atatgacacc   1101480
accatcaaaa gaaatgcaag agtggtatag tcatagcatt aaagcttatc gcaaaaactg   1101540
attgaggggg attatacaaa ctactaagat agaggttatt caaaaacata attttagtag   1101600
aaaatgaaat acatattccc acaataaaac gcatcatatc aaggtttttg aaaaaccttg   1101660
atatgatgcg ttttataatt ttaaagactt ttttctatag tagattgaaa taagatgcga   1101720
acaaatcaat tagaaaattc aaattaattt atagaaatat tttagtattc ctgtgtactg   1101780
ttctaaattc agtctgctat atcttatttt tctatttaaa tcgcttctgt aacaaagcta   1101840
cgactttcaa gtaccttaag catggcatta gctgtatcta gcgctgtgaa gaggggcacc   1101900
ccgtgttcaa tggctgaacg acgaatttgc tcaccatctt cgtcagcagt tcgttttgtt   1101960
cctactgtgt taatgatagc ttgaattctt cctttgcgta caaaacttgg gatatcctta   1102020
tcgtcatcac caatcttacc aacaggttgg gcttgcaagc catgactagc aaagaaggct   1102080
gctgtccctt ctgtcgcaag gattccataa ccaatgtttt ggaaacgacg agccaagttc   1102140
aaggcttctt ctttggcatc atcagcgatg gtaaagacga cattaccaaa agttggcaag   1102200
tgtagataag aagcttcaaa ggctttatag agagcttttt ccaaagtagc atcagaaccc   1102260
ataacttcac ctgttgactt catttcagga ccgagcaagc tgtctacctt agctagtttg   1102320
gtaaaggaga agacaggtgc cttgatatga acacgggtgc tttcagggta aagtccattt   1102380
tggtagccaa gttctgataa actttgacca agaatgagtt tggtcgctac ttgagccata   1102440
ggaatattgg ttaccttaga taggaatgga acagtacggc tggcacgtgg attgacctca   1102500
ataacgtaga ctttttcatc cttgataaca aactggatgt tcatcattcc aaggcagtga   1102560
agaccgattg ctaagcgttt ggtgtagtct gcgatggtct cctgaacctt ttgcgacaag   1102620
gtttgtggtg ggtaaacagc cattgagtca cctgagtgga caccagcacg ttcgatatgc   1102680
tccatgatac caggaatgag tacattttta ccatctgaaa tggcatcaac ttcgcactct   1102740
tgcccaacga tataagagtc gacaagaact gggtggtctg gactagcctt aacagcagtt   1102800
cgcatgtaag aacgaaggtc ttcttcgttt tcaacgattt ccatggcacg tccaccaagt   1102860
acataagatg ggcggacaag aactgggaag ccaatcttgc gagctgcaag agctgcttct   1102920
tcttcattgg tagccgtttg tcctggtggc tgtggaatat ccaattcttt gagagcttgc   1102980
tcgaagaggt cacggtcttc ggcacgatct aggtcagcaa cctgtgtacc aaggatggtc   1103040
acacctgctt ttgccaatgg ctccgcaagg ttgatggctg tttgaccacc gaactgaacg   1103100
ataactccct ttggttgttc caagtcaatg acgttcataa catcttcgaa tgtcaatggc   1103160
tcaaagtaaa gcttatctga tacagagaag tctgttgaaa cggtctctgg gtttgagttc   1103220
atgatgatag cttcataacc agctgcctgg atagccttaa cagagtgaac ggttgcgtag   1103280
tcaaactcaa ccccttgacc gatacggatt ggacctgaac ctaggacaag tacagattct   1103340
ttatcagatc tgatagattc attttcccaa ccataggttg aatagaaata tggcgtttcg   1103400
gagtcgaact ctgccgcaca agtgtctacc atcttataaa ctggaacaat cttgttttcc   1103460
aagcgaagtt ggcgaacttt atcatcagtc gttccccaga gttcagcaat cttacggtct   1103520
gaaaaaccat taagtttggc tgttttcaaa acttctaaat cttgtggatg agcacccaat   1103580
tcttgctcaa tttcaaagat atgcaagagt ttatcaagat agaagatatc aatttttgta   1103640
agctctgcaa tttcttcagg tgtgtagcca cgacgaatgg cttctgatac gtagaagaga   1103700
cggtcatctt gggctttgac aaccttttca atcaaggcat catcagaaac tgctgcaagt   1103760
tcaggtattt cattgtggtg caccccaatt tcaagggagc ggcaggcctt gagaagagat   1103820
tcctcgatgt tacgaccgat tgccatgact tctccagtcg ccttcatttg tgtaccgaga   1103880
cggcgttcac ccttttcaaa cttgtcaaat gggaaacgtg gaatcttagc aactacgtag   1103940
tcaagggctg gttcaaacat ggcataggtt gaacctgtaa ctgggtttat aacctcatcc   1104000
aaggtcaaac ctactgcaat cttggcagcc aacttagcaa tcggatatcc tgtcgcttta   1104060
gaagcaaggg ctgacgaacg tgatacacga gggtttactt cgataacata atacttgaag   1104120
ctgttaggat caagagctag ctgaacatta catccacctt caatcttgag ggcacgaata   1104180
atgctcaagc tcgcatcacg aagcatttgg ttttcatagt ctgacatggt ttgcgcaggg   1104240
gcaaatacaa tggaatcccc tgtgtgaatc ccaactgggt caaagttttc catgttacaa   1104300
acaaccaagg cattgtcagc tgagtcacgc atcacttcgt attcaatttc cttgaaaccg   1104360
gcaatcgaac gctcaatcaa acattgggta acaggtgaca atttcaaacc attttcagtg   1104420
atttcacgca attctttctc gttggcacac ataccaccac cagtaccacc aagggtaaag   1104480
gctggacgaa cgatgactgg gtagccaatt gtcgctgcaa aggcaactgc ttcttctact   1104540
gtgttaacaa tttcagattc tggaatgggt tgttcaagct cttccatcaa ttgtttaaag   1104600
aggtcacggt cctccgcttg gtcaatggca gataatttgg tacccagaag ttcaacgcca   1104660
agctcgtcta ggataccatt tttagataat tccatggcca tgttgagacc tgtctgacca   1104720
ccgagtgttg gtagcaaggc atctggacct tccttacgaa gaatacgtgt cacaaactca   1104780
agtgtaatcg gttcaatgta aaccttgtca gcaatttcct tgtccgtcat gatggttgca   1104840
ggatttgagt taaccaaaac aacctcataa ccttcctctt tcaacgacaa gcaagcctga   1104900
gtcccagcgt agtcaaactc agcagcctga ccaataataa tcggaccaga accaatcacc   1104960
ataatttttt gaatatcagt acgtttaggc atatataaga tattaagggt gtcaagcgga   1105020
caaagctaaa ataggagtta tgacgaagaa ctgtcagttc taggaataac tatcttttta   1105080
gcaccgtccg tagcccgtat tcagttcagc aaatacggag cacccttctc ctttctattc   1105140
gtcgcctctc agggcgacat taaataagat acaaaggacg aatagaaagc gattgaattt   1105200
taggaaatca aggaaggatt gacaatccaa gttggtttct ctacattctg agctttccgt   1105260
ccgtgttcag ttacataaat tctccgacga gcttttactc gttcttagtt tgattgttta   1105320
aaaacttcca tcatctcgat aaactcgtca aataggtagc tagcgtcgtg tggcccagga   1105380
gctgcatctg ggtggtattg aacagagaaa gcaggttggt atctgtggcg cacaccttcc   1105440
actgacttgt cattgatttc ttcgtgggta ataatcaagt gctctggcaa atcctcgcgg   1105500
ctgactgcat aaccatggtt ctggctggtg aagtctactc gtcctgttgc gatttcacgt   1105560
accgcatggt tgaatccacg gtggccaaac ttcatcttat aggtcttagc cccgtttgcc   1105620
attgcaaaga gttggtgtcc catacaaata ccaaagattg gaatttttcc ttgtacaccg   1105680
cgaatcatgt cgagtgcttg tggaacgtct tctgggttac ctggaccatt tgacaacata   1105740
actccgtcag gattgagatg gagaatttct tcagccgttg tcgaataagg aacaactgtc   1105800
acgttacagt tgcgtttaga aagttcacgt aggattgagt gcttgagacc aaagtccact   1105860
agcaccacgc tcaaaccaac tcctggagct ggataagacg ttttagtaga aacctgtttg   1105920
atattgtctg tcggtaaaac tgttgcttgg agctggtccg tcacatggtc catactgtcc   1105980
ccaacatggg tcaaggttgc acgcatagta ccatgcttac ggataatctt ggtaagagca   1106040
cgcgtatcaa ttcctgaaat ccctggaatt ttcttggctt tcaaaaattc atccaaggtc   1106100
atttggttgc gccagttgct agctctacgc gcttcttcaa aaacaacgac tcccttacaa   1106160
gttggaataa tggattcata atcatcacga ttaataccat aatttcctac caaaggataa   1106220
gtaaaggtca agatttgtcc attataagac tggtctgtaa tggattcttg gtagccggtc   1106280
atccctgtat taaagacgat ttcgcctgtt acatcaatat ctgctccgaa ggccttgcct   1106340
tcaaaaactg tgccatcttc taatactaga attctttttg tcatattttc acctctcgtg   1106400
gacgctcact ggcgtctttt aacgtcttgt gttttagttg gcgtttctac tcgctagtac   1106460
ggattctaag attgccattc gaacaaagac accattggtc atttgttgga caatccgtga   1106520
ttttggtgct tcaaccaagt ggtctgctat ttctacatca cgattgattg gagctgggtg   1106580
catgaggatt gctgtttctt tcaaacgatc gtaacgttct tgagtcaagc catgttgggc   1106640
atggtagtct tcttttgaaa atacagctcc actatcatgg cgttcgtgtt gcacacggag   1106700
aaacatcatg acatcaacct gatcaatgat ttcatcaatg gttacaaact gtccatagtc   1106760
tgcaaactct tgacttctcc attcctcagg tccagcgaaa aagagttcag ctcccaagcg   1106820
tttcaaaatc tgcatattgg atttggcaac gcgtgagtgg tccaagtcac ctgcaatagc   1106880
aactttaaga ccctcaaagt ggccaaattc ctcataaatg gtcatcaaat caagcaagct   1106940
ctggctaggg tgttggcccg aaccatctcc accattgatg atggaagtcg taatcgttgg   1107000
actagcaatc aattctctat agtagtcgac ctctggatgg cgaatcacac agacatccac   1107060
tcctaaagca gacagagtca aaatggtgtc ataaagtgtc tcacccttat taaccgagct   1107120
agtcttcaca tcaaagtcaa gtcgttccaa tccaagttta atctctgcga cttcaaagga   1107180
cttatgtgtc cgtgtagaat cctcaaagaa gagattggaa acaatcggat ggtcttcata   1107240
gggaagctgg gctccatttt taaactcaat tcctcgcttg atcaatttca ttacttgatc   1107300
gacagtgagg tcttccatgg acaccacatg gttcaatgct tgttgatttt ctgacatggc   1107360
tactccttta actttctaag cttcttcagt aatcagaact ctgtcttggt catcaagttc   1107420
tgtcatctct acgatgattt cttcagaacg actggttggg atattttttc caacgtaatc   1107480
tggacggatt ggcaattctc tatgtccacg atcgactaga actgctaaac tcacacgcgc   1107540
aggacgacca tgaccgacaa tattatcaat agcagcacgg atggtacgac ctgtatagag   1107600
cacatcatcc accaagataa cttcgcggtc tgtcacatcg acagaaacca aagaagtatc   1107660
ttctccactt ttaacatcat cacggaaagg tttagtatcc aattccacaa caggaactga   1107720
aagattttct aactgcttca aacgttcttg gattcggtgg gcaataaaga caccacgagt   1107780
tttaatacca gccaagacga tcttattcaa atctttgttg cgttcgataa tctcataagt   1107840
aatacgcgta atcgctcgtt tgacggtcaa ttcgtctaca acttcttttg ttttcatgac   1107900
aaacctccaa aaagaaaagt ctccttaaac aaggagactt gaaatttata gccaagcgag   1107960
ccctactgca cacagtatag acttcaccct tctactttat cgcgctcctt gcctgcctca   1108020
cgggacaggt ttaaaggaat atttagttat catttactat agcacaaagc atgcttaaaa   1108080
tcaagcaaaa agtttcaatg tagcatctta caaattgcta aaatcatata attgtgggta   1108140
ctggtcacac tctggatttt ttggatggca aatggctctt ccaaaataaa tcatggcctg   1108200
atgggcagct aaccactgct caggcggcaa gatatccatg acccgctttt ccacctcaag   1108260
tggcgtcgct gattttttga caatatcgtg gtgtttgcaa atacgctcca catgagtatc   1108320
cactgcaaag gctggaattc caaatcctac actcatgaca acattggctg tcttgcgacc   1108380
aacacctgcc aaactctcca attcttcacg tgtctgaggg acttgaccat caaaatcgtc   1108440
tagtaactgt tgggcacatt ttttaaggaa tttagcttta ttccgataca atcccaagcg   1108500
agaaatatgt gaagcaatct cactctctgt cgctacagac atagcttggg gtgttggaaa   1108560
ggcaacaaag agacctggtg tggccttatt taccgctgca tctgtcgtct gggctgataa   1108620
catgaccgca accaggagtt caaaatgatt ggtaaaatca agactaggct tggcatctgg   1108680
gaagagggca atgatttctt ctagcacctt tcgtgctcgt ttttttgaca agaccattat   1108740
tcatctccgt caaatagtcc ttgtaagcca gcaaaaggac tgttttcttc tttctttact   1108800
gctttttgag cttggtattc ttcctctgtc atgatttgcc agtcatttcc tgagataaat   1108860
ccttgaccag cttcttcttc agccgtcaag accttgatag gaatgtttag caggatattg   1108920
tctgatacac tctcagcaag gtcaagctcc ccattttcga tgggcaagac caagtcatca   1108980
tctaaaactt cttgatctag ctggttagtt gcgccttcca tgaaaacttc cgtgactgga   1109040
taagattcaa ctaactcaac tggctccata ctgcgactcg aagcaagaac aatggtataa   1109100
gatagttgat aatctaagaa atacatacgg tcttcatatt gtactttccc aactgcaagg   1109160
atatctttta catctaaaat ttcttgatta cgtgcacgca ggtcatcaac taaatctaac   1109220
gtttgttcaa agttcaaacc ttcagactgc ttacgaattt cttgaatatt taatttcata   1109280
cttcctccat aaagatttac tctcttgatt ataccatgaa aaggctacaa atcagcacac   1109340
caaactttgt aattaaaatt caaaatttta acatatttac tatgatagtt ttatttttta   1109400
gtgctatact atagggaaag agtacatcag atcaaggagg atgctcacat ggaagacaag   1109460
aaactcattc aactcctatc caagttaaat aaaagctacc aaaactgtaa acagggtacg   1109520
gcagatgata ttcgactaca agagctgcta aacactacta tgcaagagct caaaaaaacg   1109580
gaacagttga acaacagtat cttaattgat cttgagaaat tttaccaacc taccagtctt   1109640
ctgattggac tgggtagcct aaaactaaac gatcaagcac gcactgcttg gcgaaactat   1109700
gataaattcc attacgatca tgtcaaacac gtactaagtc tctatggacc tgtttttgaa   1109760
ttttagagca tagaatttcc agttttctgt tgacaaaatt tccttaaagg tataatataa   1109820
agatactaat actcggaggt aagggagaca tgaacaacta agtctatcaa ataaagaacc   1109880
tttatttagt agatcttgtt tttgtctctt tttgtgtgct cttttatgct ctttttctgg   1109940
catgttaata gagttttttt gacatagact ttgggctcta ctaggtaaag tagagctttt   1110000
tgttatgcac tatgaacatt ctagaaaggg aaatcatatg ataaaaatca atcatctaac   1110060
catcacacaa aacaaagatt tacgagatct tgtatctgac ctaaccatga ccatccaaga   1110120
cggggaaaag gttgctatta ttggtgaaga aggaaatggc aaatcaacct tacttaaaat   1110180
tttaatgggg gaagctttgt ctgatttcac tatcaaggga aacatccaat ctgactatca   1110240
gtcactggcc tacattcctc aaaaagtccc tgaggaccta aaaaagaaaa ctttacacga   1110300
ctacttcttt ttagattcta ttgatttaga ctacagtatc ctctatcgtt tggcggagga   1110360
attgcatttt gatagcaatc gtttcgcaag tgaccaagag attggcaatc tatcaggggg   1110420
cgaagctttg aaaattcagc ttatccatga gttagccaaa ccctttgaga ttctattttt   1110480
agatgaacct tcaaatgacc tagaccttga gacagttgat tggctaaaag gccagattca   1110540
aaagaccagg caaaccgtta ttttcatttc ccatgatgaa gactttcttt ctgaaacggc   1110600
agacactatt gttcacttgc gactggtcaa acaccgtaaa gaagcggaaa cgctagtaga   1110660
gcatttagac tatgatagct atagtgagca gagaaaggct aattttgcca aacaaagtca   1110720
gcaagctgct aacaaccaaa gagcctacga taaaaccatg gaaaaacatc ggagagttaa   1110780
gcaaaatgta gaaactgcgc ttcgagctac caaagatagt actgccggtc gcctattggc   1110840
taaaaagatg aaaactgtcc tctcacaaga aaaacgctac gaaaaggcag ctcagtccat   1110900
gactcaaaag ccacttgaag aggaacaaat ccaacttttc ttttcagaca tccaaccatt   1110960
accagcttct aaagtcttag tccaactgga aaaagaaaat ttgtccattg acgaccgagt   1111020
tttggttcaa aaactacaac taactgtccg tggccaagaa aaaatcggta ttatcgggcc   1111080
aaatggtgtt gggaaatcaa ctctgttagc caagttacag agacttctga atgataaaag   1111140
agagatttca cttggtttta tgccacaaga ttaccacaaa aaactgcaat tggatttatc   1111200
cccaatagcc tatctcagta aaactgggga aaaagaggaa ctacagaaaa tccaatctca   1111260
cctagctagt ctcaatttca gttatccaga aatgcagcat caaattcgct ccttatctgg   1111320
cggacaacag ggaaaactcc tgcttttgga tttagtcctg cgcaaaccaa actttctcct   1111380
gctggatgaa cccacacgaa acttttctcc cacttctcaa ccccaaatca gaaaactctt   1111440
tgctacctat ccaggcggtc tcatcactgt ttcgcatgac cgtcgtttct taaaagaagt   1111500
ctgctcgatc atctatcgca tgacagaaca cggtttgaag ctagttaatt tagaagattt   1111560
ataaatttgc aacatagcaa aaatccagag acgacctctg gattctttta catctgtttt   1111620
aaacgttcaa tccgttctga gataggtggg tgggtataaa agagtttttg gaacccccca   1111680
cctttcttag gatcattgat ataaagggca ctgctagcat catcgacgtg gcgactcata   1111740
ggtttgctat tgtccaactt atctagggca ttaatcattc cctggggatt gcgagtcagc   1111800
tcgacactag atgcatctgc cagaaattcc ctctgacgag aaatagcgag ctgaaccaag   1111860
gttgcagcga gaggtgccag tacaatagct agtagggaaa ccactagcat aatgatttca   1111920
agaccatttc catctcggtc atcatcactt cgtctgcgac ctgctccacc ccaccacatc   1111980
atacgacctg ccatactaga aagcatggtg atagcactag caagggcaac tgcaatagtc   1112040
gaaatacgga tatcataatt acgaatatga ctgacttcat gtcccataac agcttctagt   1112100
tcttcacgat tcatgatagc tagtagacct gaagtcgcag caacagccgc attttgagga   1112160
ttagaacctg tcgcaaaggc atttaaggct ggatcatcaa tgatgaaaac acggggcata   1112220
ggaatctgag cgaccagagc catatcttcc actacatggt agaggtctgg tgccgtttgc   1112280
tcatccacct cacgcgctcc attcatggac atgacaatct ctgtcgattg aaaaatcata   1112340
gacaaagcgt agataaagcc gataatcagt gcaataacca aaccaccaag tccagatctt   1112400
ataaagagat aaccaaccgc ataaccaaca agagctaaga gtaggaaaaa taccagcaac   1112460
aaaatccagg tttttcgttt attgcttgca atttgatcaa acaacatctt agtcacctaa   1112520
accgctaaaa tcaactttag gaaccgactt ttcctcttca ggtgtttgaa ggaaatctgc   1112580
cgctttaaat ccaaacattc cagcgataat attgctcggg aaagtttcta attttacatt   1112640
gtagttgctg acaacactgt tatagagttg acgagagtaa gaaattttat tttctgtgtt   1112700
tgtcaactcc tcttgcaatt taacaaagtt agcactagct ttcaaatctg gatagctttc   1112760
tgcaactgca aaaatacctg aaacctgacg agtgagggca tcactggctt tcatagcttc   1112820
tgctggtgaa gtcgctgccg ccacttggtt acgtagttct gccacctttt caagggtaga   1112880
accttcatat ttggcataac cttttacagt ctcaatcaag tttggcaaga ggtcattgcg   1112940
acgtttcaac tgaacatcaa tctgactcca agcctccttg gtttgcatac gatttttaac   1113000
caaaccgtta tagctaacaa tcacaaaaat aacaataaga gcgataactc caagaataat   1113060
ccaagtcata atataagtcc tttctgcttt tagattagta ccagtatatc aaattttcta   1113120
tgattgtggt aaaataagat gatactaaag aaggaaataa ctatgaaacc aaaaacattt   1113180
tacaacttgc ttgccgagca gaatcttcca ctttcggacc agcaaaaaga acaatttgaa   1113240
cgttattttg agctcttggt cgagtggaat gagaagatta atttgacggc gattacggac   1113300
aaggaagaag tttatctcaa acatttttac gattcgattg cacccattct tcaaggtttg   1113360
attcccaatg aaactatcaa acttcttgat atcggggctg gggcaggatt tcctagtcta   1113420
ccaatgaaaa ttctctatcc ggagttagat gtgaccatta ttgattcact caataagcgc   1113480
atcaacttcc tacaactctt ggctcaagaa ctggatttga acggagttca tttctaccac   1113540
ggacgtgccg aagattttgc ccaagacaag aacttccgtg ctcaatatga ttttgtaaca   1113600
gctcgtgcgg ttgcccgtat gcaggtccta tctgaattga ctattcccta ccttaaggtt   1113660
ggtggcaaac tattagcact caaggctagc aatgcgcctg aggaattatt agaagctaag   1113720
aatgccctca atctcctttt tagtaaggtc gaagacaatc tcagctacgc cctaccgaat   1113780
agagatccgc gctatatcac agtggtagaa aagaaaaaag aaacaccaaa taaatatcca   1113840
cgtaaggctg gtatgccaaa taaacgccca ctttaaattt tttagtaaac aaatgtttac   1113900
aaaatcagcc tcgctctttt atttctaggc tcgggaaaaa atgatttaca aaatcagcct   1113960
cgctctttta tttctaggct cgggaaaaaa tgatttacaa aatcattttt ttctgctata   1114020
ctatcctaag caaaggtttt taatgtcatc ccgtgaggtg acgaagacgc agaaatattt   1114080
aaaactcttt aaaatctaaa ttttaaagaa gtcttactct gagggcctat tgctgtaaaa   1114140
taatgggctc ttttttgatg cccaaaagtg aggtttatat gaaacaagaa tcaactgttg   1114200
atttgttact agacgttgac caacgtcctt cggctggaaa aggaattctc cttagtttcc   1114260
aacacgtttt cgccatgttt ggtgcgacca tcttggtacc attgattttg ggaatgcctg   1114320
tatctgttgc cctttttgct tcaggtgttg gaacactcat ctacatgatt gctactggtt   1114380
ttaaagttcc agtttatcta ggttcttcat ttgcctttat cacagctatg tcactggcta   1114440
tgaaagaaat ggggggggat gtatctgctg cccaaacagg ggttatcttg actggtttgg   1114500
tctatgtcct tgttgctacc agcatccgat ttgtaggaac aaaatggatt gataaactct   1114560
tgccaccaat cattatcggt cctatgatca tcgttatcgg tcttggactt gcaggttcag   1114620
ctgttaccaa tgcaggtctt gtagcagacg gaaattggaa aaatgctctg gtagccgttg   1114680
ttactttcct aattgctgcc tttatcaata caaaaggaaa aggcttccta cgaatcattc   1114740
cattcctctt tgccattatc ggtggttacc ttttcgcact aactcttggc ttggttgact   1114800
ttacaccagt tcttaaagcc aactggttcg aaattcctgg tttctacttg ccatttagca   1114860
caggtggtgc ctttaaagag tacaatcttt actttggtcc agaagccatc gctatcttgc   1114920
caatcgctat cgtaacaatt tctgaacata tcggagacca tactgttttg ggtcaaatct   1114980
gtggtcgtca attcttaaaa gaaccaggtc ttcaccgtac tcttcttggt gacggtatcg   1115040
caacttctgt ttctgccttc cttggtggac cagccaatac aacttacgga gaaaatacag   1115100
gggttatcgg tatgactcgt atcgcttctg tctcagttat ccgtaacgct gccttcatcg   1115160
cgattgccct cagcttcctt ggtaaattca ctgccttgat ttcaactatt ccaaacgctg   1115220
tacttggtgg tatgtcaatc cttctctatg gggttatcgc cagcaatggt ttgaaagtct   1115280
tgattaaaga acgtgttgat ttcgctcaaa tgcgaaacct catcatcgca agtgctatgt   1115340
tggttcttgg acttggagga gctatcctta aacttggtcc agttacactt tcaggtactg   1115400
ccctttcagc catgacagga atcatcttga acttgatctt gccatacgaa aataaagact   1115460
aagagtctaa atacacctaa tccactcaga cagctgagtg gatttttcgt ataccataat   1115520
aaaagtgtct taacaaaatt attaaaatca aaaaacgtat aatatcagat attctaaaac   1115580
cttgatactg tacgttttat catagaaatt tttactttat tttctcatca aatgagattt   1115640
gcatcaatct cttgtcttac ttgcgtttct tcttcgcttt cttcattttg ttagccatac   1115700
gtttcatgga ctgtttcatg gcaaattcac caattttacc tttcaaaccg ccaccaaaca   1115760
tctggctcat atctggcatt cctgctcctc cgagagctga taagtcaggc ataccgcctt   1115820
gtcccatcat tccttcaagg gcagacatat ccattcctcc catatttggc atatttttag   1115880
gaaggttatt tggattaatc cccatttgct tcatcatttt attcatatcc ccagacataa   1115940
caccctgcat gagctgttta gcctggttaa agtccttgat gaatttattg acttcgacga   1116000
atgtatttcc agaaccagca gcaatacgac ggcgacggct tggatttaac aaatctgggt   1116060
tttcacgctc ttcaggtgtc atcgaagaca caatggcacg tttacgagca atctggcgtt   1116120
catccacctt catgttttga agggctggat tgttggccat acctggaatc atcttgagca   1116180
agtcttccat cggccccata ttttgcacct gatctaattg atcgatgaaa tcattaaaat   1116240
caaaggtgtt ttcgcgcatc ttctcagcca tttcaagggc tttttgttca tcgtattcct   1116300
gagaagcttt ctcaatcaaa gtgagcatat cccccatacc aaggatacgg ctagacatgc   1116360
ggtctgggtg gaaggtttca atgtccgtaa tcttttcacc tgtaccagtg aacttgattg   1116420
gttttccagt aatgtgacga acagacagag cagcaccacc acgagtatcg ccatcaatct   1116480
tggtaaggat gaccccagtc acttccaact gagcattaaa ctcacgcgca acattggctg   1116540
cttcctgacc aatcatagca tcaacgacaa gcaagatttc atttggttga gccaatgctt   1116600
tcacatcacg aagctcattc atgaggagct catcaatctg caaacgaccc gcagtatcaa   1116660
tcaagacata gtcgttatga ttagtttggg cttgctccaa accttgacgt acaatctcaa   1116720
cagctggtac ttctgttcca agtgcaaaga caggcacatc aatctgttgt cccaaggtct   1116780
taagctggtc aatggcagct ggacgataaa tatccgccgc aatcatcaaa ggacgagcat   1116840
tttcttcttt cttgagtttg ttggccaatt taccagcaaa ggttgtttta ccagcccctt   1116900
gtaaaccaac catcatgatg atggttggaa tcttaggtga cttgataatt tctgccgtat   1116960
cagaacctaa aacggctgtc aattcctcat caacgatttt aataatctgt tgcgcaggat   1117020
taagtgtatc aatgacctca tgcccgactg cacgctcacg aactttcttg ataaagtcct   1117080
ttacaacagg caaggcaacg tcggcctcga gcaaggccaa gcgaatttct ttggttgcct   1117140
cttggacatc agattcagag atttttcctt ttttacgtag atttttaaag acgttctgca   1117200
aacgttctgt taaactttca aatgccattt ttcttcctct tattctctat tatcaatgct   1117260
tgttaaaatt tctatctgct cctgcagaaa gtcatccttg ggatagcgct ccaaaatctg   1117320
atcaaaaatc tgactgcgga caatatagtc cgagtacatg tgcaatttca tctcataatc   1117380
ttccagaatc ttttctgttc gcttgatatt gtcatagaca gcctgacgac tgacaccgaa   1117440
ctcctcggca atttcagcaa ggctgtaatc atcagcgtag tagagctcga tataattcat   1117500
ttgcttatct gtcaaaagcg ccgcataaaa ttcaaagagc gcattcatac gattggtttt   1117560
ttcgatttcc ataactttta ttataccaaa aattagccta atctaccaca ctaggaagcc   1117620
gatccaagaa gatagatagc taaatttgaa aaagacatga gcctagcccc aagtaatttc   1117680
caattgatag ctggcaaagg gatgtccctc ttgattttgt agttgataat ctagttcaat   1117740
cttttgccta tcaacttgat aatggctcgt ttggatgata aactcctgca tgcccatagg   1117800
tgtaggaata taggctaaac tatcgctatc ctttagaaag cgcataatgg tcttgggatt   1117860
agaaaatcgg ctcatcacaa gttcttgacc atgaaattta atcactactt tttccttttc   1117920
ctcattatag aaaagcaggt agctataatc tcctttttca tgcacttcca catcataaag   1117980
ctggtcaatc acttccaact gctcatcaaa ctgaatcgta tttcgcatcc gaatcttcac   1118040
atcaggccct ctttcttgtc tcttgtccta ctattttacc aaaaagagca ggattttgct   1118100
ataatggtca tatgaacgaa aaagtattcc gtgaccctgt tcacaactac atccatgtca   1118160
ataatcaaat catctatgac ttgattaata caaaagaatt tcagcgtttg cgccggatca   1118220
aacaactggg aacttccagt tataccttcc acggtggaga acacagtcgc ttctctcact   1118280
gtctaggagt ctatgaaatt gcacgacgca tcacagagat tttcgaagaa aaatatcctg   1118340
aggaatggaa tcctgccgag tctctcttga ccatgaccgc tgctctccta cacgaccttg   1118400
ggcatggtgc ctactcccat acttttgaac atctctttga tacagaccat gaagccatta   1118460
ctcaggagat tattcaaaat cctgagacag agattcacca agtcctgcta caagtggcac   1118520
ctgatttccc agaaaaggtg gccagtgtca ttgaccatac ctatcctaat aagcaggtcg   1118580
tgcagctcat ttctagtcag attgacgcag atcgcatgga ctatctcttg cgcgactcct   1118640
attttacagg agcatcctat ggggaatttg acctgactcg aatcctccga gtcattcgtc   1118700
ctatcgaaaa tggtatcgcc tttcagcgca atggcatgca cgccatcgaa gactacgtcc   1118760
tcagtcgcta ccagatgtac atgcaggttt atttccaccc cgcaacacgc gccatggaag   1118820
ttctcctaca gaatcttctc aaacgcgcca aggaactcta tcctgaggac aaggatttct   1118880
ttgcccgaac ttctccacac ctcctgcctt tcttcgaaaa aaatgtgacc ttgactgact   1118940
atctggctct ggatgatggc gtgatgaata cctacttcca gctttggatg accagtcctg   1119000
acaagattct tgcagattta tcgcatcgct ttgtcaaccg caaggtcttt aaatccatta   1119060
ccttttcaca agaggaccaa gatcaactta ctagcatgag aaaattggtt gaggatatcg   1119120
gctttgatcc cgactactac actgccattc ataagaactt tgacctccct tatgatatct   1119180
atcgtcccga atctgaaaac ccacggacac agattgagat tttacaaaaa aatggagaac   1119240
tggccgaact ctctagcctg tctcctatcg tccaatccct tgctggcagt cgccacggag   1119300
ataatcgctt ttattttcca aaagaaatgt tggaccaaaa cagcatcttt gcaagcatta   1119360
cccagcaatt tttacacttg attgagaacg atcattttac cccaaataaa aactagaaga   1119420
ggaaatttat gagtattaaa ctaattgccg ttgatatcga cggaaccctt gtcaacagcc   1119480
aaaaggaaat cactcctgaa gttttttctg ccatccaaga tgccaaagaa gctggtgtca   1119540
aagtcgtgat tgcaactggc cgccctatcg caggcgttgc caaacttcta gacgacttgc   1119600
agttgagaga cgagggggac tatgtggtaa ccttcaacgg tgcccttgtc caagaaactg   1119660
ctacaggaca tgagattatc agcgaatcct tgacttatga ggattatcta gatatggaat   1119720
tcctcagtcg caagctcggt gtccacatgc atgccattac caaggacggt atctatactg   1119780
caaatcgcaa tatcggaaaa tacactgtac acgaatcaac cctcgtcagc atgcctatct   1119840
tctaccgtac ccctgaagaa atggctggca aagaaattgt taaatgtatg tttatcgatg   1119900
aaccagaaat tctcgatgct gcgattgaaa aaattccagc agaattttac gagcgctact   1119960
ccatcaacaa atctgctcct ttctacctcg aactccttaa aaagaatgta gacaagggtt   1120020
cagccattac tcacttggct gaaaaactcg gattgaccaa agatgaaacc atggcaatcg   1120080
gtgatgaaga aaatgaccgt gccatgctgg aagtcgttgg aaaccccgtt gtcatggaaa   1120140
atggaaatcc agaaatcaaa aaaatcgcca aatacatcac caaaacaaat gacgaatccg   1120200
gcgttgccca tgccatccga acatgggtac tgtaaaagta tcatttttca ataagaattg   1120260
attagcaata aaatccaatg aattttttta gcaaactatt taatttaaaa caaaataatc   1120320
ataatagaga cacaaattct gattgtaaca atttttacct aaacgaatta gaatgtggcc   1120380
ttactcctgg gcaactcata ctcatagatt ggactcaaaa aacagggaga aattataatt   1120440
tcccaagata ttttaaatac tctcttcaaa ttgaccctga atctacacac aatcaattat   1120500
acaaattagg atacttcact aaaaataaga ctttatcata tcttacagta gtagaattaa   1120560
aaactatatt atctaaacat aatttagcta cttctggaaa aaaagcagaa ttaattacaa   1120620
gaataattaa taatgttaac attgacaatt tagatattcc gttcgaattt aaactaacaa   1120680
aagaagcaca aaatcttatt atcgaacata gtgactatat caaagcatac tatgataaag   1120740
acataactat ggaagattat tgtaaagaaa aaaacaatat ctcttttaaa gcaacttttg   1120800
gtgatataaa atggagtctc ttaaataaac aagctcatag gaatactgta tcaggagatt   1120860
ttggatgctt atctaacaca cgaaaggctc agggaagaca tttggaacaa gaaggtaata   1120920
ttaaacatgc tttaatatat tacatagaat ctttgataat tactatttca ggattagaaa   1120980
acaatttttc agccactgat tatccagtat attatcccga ttcgatacct gactactcac   1121040
taaaacatat tcaaacatta atggaatcat tatctgatga cgattatgat tttgcttttg   1121100
atgaagcatt atttcgcttc tcaattttga atgcaaatca ttttttatct aaggaagata   1121160
ttgactattt aagagttaat ttacctcgtt ccactgctga agaaataaac aattacttaa   1121220
agaaatatga atgttatagt cctttaaata atttagaact tgacgatttt gaataaattg   1121280
actatacaaa catttatata ctcgatatag tctcaatttt atctgatgat tgcccaaatt   1121340
tttcaataat aaaacgcata atattatgga gacaatcccc tatattatgc gttcttttaa   1121400
tatcaaagac tttttgacaa acttctttga tatctaatta catgccccct gcaggaatcg   1121460
aacctgcaac tactccttag gagggagttg ttatatccat tgaactaagg gagctagata   1121520
aaaactctgc taaatgagca gagtttttta gtcgaattaa cgacggattt ctttgatacg   1121580
agctgcttta ccttgaagag cacgcaagta gtacaatttc gcacgacgta ctttaccgta   1121640
acgaacaact tcgatttttt caacacgtgg agtgtggatt gggaagatac gctcaacacc   1121700
tacaccgtta gagattttac gaactgtgta gttttctgag attccagcac ctttacgtgc   1121760
gataacaaca ccttcaaaaa tctggatacg ttcacggtta ccttcgacaa ctttcgcatg   1121820
tacacgaaca gtgtcaccag gacggaatga tgggatatct gtacgaagtt gaccttcagt   1121880
caagctttgg attaatggat tcattttatt ctcctatctt tgtcaatctt gaggaatctt   1121940
cctcagcgga taaactgtat ttttgtgcgt ccattacaca caagatatag tttaccaaat   1122000
ttctaaaaaa aagtaaagaa atttatagca aaattcctaa aaaaatcgca accaaaccac   1122060
ctatgtaagt caaagtcagg taagaataaa agaccttctt atcacttagc agtctttgaa   1122120
gttcgtcatt caaggtcgaa aaagttgtta aaccgccaca aaatcctgtt gctagaatag   1122180
catatacttc cttagactct acatgattgt agaatactcc aattaaaaaa caacctaaaa   1122240
gattagctat gagcgttccg agtggcaatt tagaagcttg attatagcga gaaaagaaat   1122300
accgtacgag tgctcccaag ccacaggcga ttgcaagata gacgattacc atttcttcct   1122360
ccccaaatag taagctaaaa gcaggcctcc accgatactc aaaagcaaat acagtatcaa   1122420
actaagataa cgccctgtat caagcagctt cacagtatca agcattaggc tggaaaaagt   1122480
tgttaaacct ccgcaaaaac ccgtccccag tgctaaaatc aagcccttac tagtcccctt   1122540
atagaccaga tagcccttga caagataaat caagcagaaa attcccagat agttgacaaa   1122600
gagagtgccc caagggaaat ctggactggc tggtaaccag gtggaaacta gatatcggac   1122660
aagtccgccc aacatagcag ctagaaaaat tcctagcgga taaaattgtt cttttttcat   1122720
ttgatatttt gatcctgata atcacgcgaa cgtttgagta tgtccgaaaa agtcgcgaca   1122780
atagtctcct gatagcgctt gtcctctaca cgactcctaa ccttttcaaa aataacttct   1122840
tctctcttag tatctaaaat cggtttacct gaagctttct tataagcaac caccccctca   1122900
actaaatgca ttcgttcttc taacagtttg acaatttggt cgtcgatttg atcgatttct   1122960
tgacgaataa tatctaaatc catacagtct cctcctttat ttgaattatt gtatcaaaaa   1123020
gccatcaatt aggctagtaa aatcccaact ctcgataaga aaaatgcact gattgattac   1123080
atcagcgcac ttttatgttt atcctacttt agcagccaat tcttctgcga attgttccaa   1123140
gcgttcaata tcttcttcct cggcagaaag atcaacttta acacactctg aacctttttc   1123200
tgctcctgtt gacacaaaga cacggtcaaa gtcatcaaca gccttacaga attcatcgta   1123260
gaaggtatct cctgagccga ccactccgta gattttgcca ttcaagttga gatctgctag   1123320
gtcttcgtag aagtccatca tctcatctgg caattcacca tcaccataag tataggtcgc   1123380
aacgatagcg atgtctgctt ccaagaagtc tgaagcgtca acagttgtac attcatcaac   1123440
atcaacatcc aagcccaagt cacgtaattt gtctgctaca atatctgcaa tttcttcggt   1123500
attaccggtc atactggcaa atacaatttt tgctaatgcc atatcgtcct cctcaattta   1123560
tctttctcca ttatatcaca tctttttcat tttaaaaata aaaattcttg tgctacaatg   1123620
aaatgagaaa gaattgaggt tatttatgga gatttgccaa caaattttag aaaaaattaa   1123680
agaatacgac accattatca ttcatcgtca tatgaaacca gaccctgatg ccttgggaag   1123740
tcaggtggga ttgaaagcct tgctggaaca tcatttccca gaaaaaacca tcaaagccgt   1123800
cggttttgat gaaccaactc ttacttggat ggctgagatg gatcttgttg aagatagagc   1123860
ctaccaaggc gcacttgtca tcgtctgtga tacagctaat actgctcgta tcgatgataa   1123920
gcgctatagt caaggtgatt ttctcattaa gattgaccac catccaaatg atgatgtata   1123980
cggtgacctg tcttgggtcg atactagttc aagtagcgct agcgagatga ttaccctatt   1124040
tgcccaaaca acccaactag ccttggcaga tcgcgatgct gagttgctct ttgcaggaat   1124100
tgtcggtgat acaggtcgct tcctctaccc ttctaccact gcacggactc ttcgcctggc   1124160
tgcttatttg agagaacata actttgactt tgcggctctc actcgcaaaa tggacactat   1124220
gagctacaaa attgctaaac tgcaaggcta catctacgac catctggaag tggatgaaaa   1124280
tggtgctgct cgcgttatcc tgagtcagaa aatcttgaaa caatacaata taaccgatgc   1124340
tgaaactgcg gccattgtag gtgcacctgg acgcattgac agagtgagtc tctggggaat   1124400
ttttgtcgaa caggctgatg gccactaccg agttcgctta cgcagtaaag tccatcctat   1124460
caatgaaatt gccaaggagc atgatggtgg aggccaccct ctagcaagtg gtgctaattc   1124520
ctatagccta gaagaaaacg aaatcatcta ccaaaagtta aaaaacttgc ttaaaaactg   1124580
ataaaatact tgccaaactt ttcagaatct gatagactag tatagtaaca atctatggct   1124640
cgcaaagaga ccatggcaga aaggaaatat tgcaaaatga aaaaagatat ccatccagaa   1124700
tatcgcccag ttgtcttcat ggacacaact actggttacc aattccttag cggttcaaca   1124760
aaacgctcta acgaaacagt tgagttcgaa ggcgaaactt acccattgat ccgtgtggaa   1124820
atttcatcag actcacaccc attctacact ggacgtcaaa agttcactca agcagatgga   1124880
cgcgtggatc gtttcaacaa aaaatacggt ctcaaataat gataagagaa cagttttggc   1124940
tgttcttttt tgtttcttga aatcaactgc tgttttcatg ttccagactc atctgtaggt   1125000
tcgatttcca tgctactagg caggaaggaa atagctgttt caacacgtcc ataatgagct   1125060
atactattgt cacgaaccac actttcattg atggtccaag tggaattcat tttcttaaaa   1125120
gcttctcgga ctttttccaa atctttggag gcaatggcct gctctaaggt ttcaaaacga   1125180
ggacttatac tcatctgctt tcaaaaagca ttctagtcca tctccgatta ccgatggact   1125240
ttatcacctc cttctccagt ccttgtatga catcttgaag ttgattcatg acatcttcca   1125300
aagttcgaaa ggctttattc ttaaatccac gtttacgaat ctctttccac acttgttcaa   1125360
tgggttcatc tctggtgtgt atggaggaat aaaggtaaaa tcaatattag tcggaatatt   1125420
taaggtactt gatttatgcc atatagcatt gtccataacg agtaaaagga taagcttgtg   1125480
aaagctcttc taaaaaggcg ttcatccaca ctccttttta taaacctgaa ataaggcatc   1125540
aattgtaaca aattctcctg cctctgtagc cttcaaatga cgggcaagaa aggctttctc   1125600
ttcctcaact gtcatatatg catggttacg accaccacgt gtttcttgaa ggagagagtc   1125660
gagtccgaac tcctcatatt tttttacgtt tcgccaaatc gttgtttgat tacagtctaa   1125720
aagctctata atctctttat aagatttgcc catcagacga aatatagtag attgaaacta   1125780
gaatagtaca cctctacttc taaaacattg ttagaaatcg atttgtcctg ttcttgtttc   1125840
attttactat agaacgattt gaaggcgttt ataatattta gctgtacgag agtcttttaa   1125900
aagtgttttg atggtttgga tttcttcttt agttgatttc atattactat tatataatgc   1125960
tttttgattt tagtctggta taaatattgc tttcctccaa aatggtcata gttttactgg   1126020
caaatctaac atatcacgga taaattaaca agtgatttct gaattgctaa acattttctt   1126080
ttcttatagc atactttaag attttgtctt tgagaaagat atttccaaga aaaacgttcg   1126140
tttttttatc tattttcaaa aaaaccaaaa aactgaattg aaagaatttt tagaaaattt   1126200
ctgttttttc tttacagtga aaaaaaattc tgctataatg tcttatgtaa taaaatatga   1126260
caataaaagg agaacgatat gacatctgct aaagaatata tccaaagcgt gtttgaaact   1126320
gtgaaagctc gtaacgggca cgaggctgaa ttcctccaag ctgttgaaga atttttcaac   1126380
actttagaac ctgtatttga aaaacaccct gagtatatcg aagaaaatat cttggcacgt   1126440
attactgagc ctgagcgcgt ggtttctttc cgtgttcctt gggttgaccg tgatggaaaa   1126500
attcaagtaa accgtggtta ccgtgttcaa ttcaactcag ctgttggacc atacaaaggt   1126560
ggacttcgtt tccacccaac tgtaaaccaa gggatcttga aattcctcgg atttgaacaa   1126620
atctttaaaa atgtcttgac tggacttcct atcggtggag gtaaaggtgg atcagacttc   1126680
gatcctaaag gtaaaacaga tgctgaagtg atgcgcttct gccaaagctt catgactgaa   1126740
ttgcaaaaac acatcggacc atcacttgac gtacctgctg gtgatatcgg tgttggtgga   1126800
cgtgaaattg gttaccttta cggtcaatac aaacgtctta accaatttga tgctggtgtc   1126860
ttgactggta aacctcttgg atttggtggt agcttgattc gtccagaagc aactggttac   1126920
ggtttggttt actatactga agaaatgctc aaagctaacg gtaacagctt tgctggtaag   1126980
aaagtcgtta tttcaggttc tggtaacgtt gctcaatatg ctcttcaaaa agcaactgaa   1127040
ctcggtgcaa ctgttatttc tgtttctgac tcaaatggtt atgtcatcga tgaaaatggt   1127100
atcgacttcg atcttttggt tgatgttaaa gaaaaacgtc gtgctcgttt gactgagtat   1127160
gcagctgaaa aagcaactgc aacctaccac gaaggtactg tatggactta cgctggaaac   1127220
tatgacattg ctcttccatg tgccactcaa aacgaaatca acggtgaagc agctaaacgt   1127280
ttggttgctc aaggcgttat ctgtgtatct gaaggtgcca acatgccgag cgaccttgat   1127340
gccatcaaag tttacaaaga aaatggtatc ttctacggac ctgcaaaagc tgccaacgct   1127400
ggtggtgtag ccgtttcagc tcttgaaatg agccaaaaca gtcttcgcct ctcatggact   1127460
cgtgaagaag ttgatggccg tctcaaagac atcatgacaa acatcttcaa cacagctaaa   1127520
acgacttcag aaacatacgg tcttgataaa gactaccttg caggagctaa cattgctgcc   1127580
tttgaaaatg tagcaaatgc catgattgca caaggtattg tttaagattt atttactcaa   1127640
tcctcaatca ctacgattgg ggatttttag cttgaattaa aaaattggaa aatctaatta   1127700
aataaaatga aatgaaataa aaactgaaca aattgattgc ggaattcaaa ccaatttcta   1127760
acatatttct agaaattaat ttgacttttc taatcgattt gttcatatct tatttcaatt   1127820
tactatactt acttgaccct ttttatactc aatgaaaatc aaagagcaaa ctaggaagcg   1127880
agccgcaggc tgtacttgag tacggtaaag caaagctgac gtggtttgaa gagattttca   1127940
aagagtatta aacaaaaaga aaaaccgcta ctcctaagaa tagcgattta atcatgtttt   1128000
taagctacta ctgtagttgc tctattattt aagtgttatg aataacttca atatctttaa   1128060
agctttttgt tagatttata atttcaacta tagccatctc tactccttag tttacagcaa   1128120
aaaattatgc ttaattctta ttgtttttgt aaacaatcag cgaacccaat actattccat   1128180
tcaacaagcc taaagaaata ccatattcaa ctggaaaatc taaaaaaatt gcaaacacta   1128240
ttccaatcat cacccctagt gaggctgttg ttaaaattac atattcattt tctttcttca   1128300
ttttctttac acctcatttc ctttttgtat ataagctgta gtactctcca ccaagatcca   1128360
ttaagtactt atgatttcct gactcaacaa tcttaccacc tttcattaca aaaataacat   1128420
ccgcatcctt aatcgttgac aatctatgag ctacaattat ttgagtacag ccctgacttt   1128480
gtatatactt tgttattctt tcctcattaa tagtgtctaa tgcactagtt gcttcatcta   1128540
aaattacaat actaggatta tttattaatg cacgtgccag tgctatccgt tgcctttgcc   1128600
cacctgaaat atttgacccc atctctgaga tgatagtatt aaatttcatc ggcatagcca   1128660
tgatttcatc atagatttga actgctttac aaacttcctc tatcttttgt gaagtaactt   1128720
cgtgctttaa agttatatta tcaagaatac ttcggttcaa taaaaatgaa tcctgtggaa   1128780
ctactcctaa attttgactt aatatttttt tatctatttg attaatattt acaccatcaa   1128840
ataaaacttt tcctgtatca atcttatata atcttgatgg tatttttgat aatagacttc   1128900
ctgcaaaact agaatcctag ttcatgattg ataataccag caatcaaatt cattcgtaat   1128960
ccgaagcgtt tagatgattt cgataggttg ttgaaatcat tttaaacgtt tttactttgg   1129020
caaagatgtt ctcaaccttg cttctctcct tagatagcgc atggttatag actttatctt   1129080
caattgttag cggtttgagt ttgctggatt tacgtgaagt ttgtgcttga ggatatatct   1129140
tcatgagccc ttgataacca ctgtcagcca agattttacc agcttgtctg atatttctgc   1129200
gactcatttt gaacaacttc atatcatgac aatagttcac agtgatatcc aaagaaacaa   1129260
ttctcccttg acttgtgaca atcgcttgag ccttcatagc gtgaaatttc tttttaccag   1129320
aataattcgc taattctttt tttagggcga ttgattttta cttccgtcgc atcaatcatt   1129380
accgtgtcct cagaactgag aggagttctt gaaatcgtaa caccactttg aacaagagtt   1129440
acttcaaccc attggctccg acggattaag ttgctttcgt gaataccaaa aacagccgca   1129500
atttgttcat aagttcgata ttctcgcaca tattgaagag tggccataag aaggtcttct   1129560
agacttaatt taggttttcg tccacctttt gcgtgtttaa gttgataagc tgtttttaat   1129620
acagctaaca tctcttcaaa agtcgtgcgt tgaacaccaa caagacgctt aaatcgtgca   1129680
tcggttagtt gtttacttgc ttcatcattc atagaactat tataccatat tttgtttcgc   1129740
aggaagtcta ttgaaaaatc tccagactgg agaactcacg gatagttcct aatctggaga   1129800
tttcttattt gcacttttct tgtacaactt tagtccatgg taaataagcc tctaaaacct   1129860
ctttgtttac gagagtttcc tcgtttggaa gacattctag aagataggat agatatttct   1129920
cgctatttaa ttgatgacgt ttagctgttt ccaacaaact cataataata gctcttgctt   1129980
tagctccttc aaaactttga gaaaataacc accctcgctt ttttaaactg agcttaggct   1130040
aaaagagtcc actggactct tttactccgt cccataacca atgatttaat ggcgcgttca   1130100
gctagattat tggaaaggac cagatgtccg tctttcaaaa tggtcttaaa ggtttcttca   1130160
tacttgaggc tgtattcaat tgcccttcct agttttgaac ctgctaaaac tgactgacgc   1130220
cggcactaag caaagaagtc ttccattaag ggctggagat gttcttgacg tttctgtagt   1130280
cgttcatcag ctggcaaagc ctcccagtct ctttccaagg aaaataactg atcacaataa   1130340
gctaaacctt tagctcctaa ggatgattta tccgcttgct tgggggggcg cttcaaaaaa   1130400
cttccttctc acatgcgccc aacatccaac aagttcagct tcttccagtt gacgataagc   1130460
agacgagcgg ttcgaagttt accaagctta gcgtcgcctt gctcctaaac cttggactgc   1130520
tatcgcatag gcagaactag aggactaaag tcctaagtta ctgccgcaaa atatcacaat   1130580
gcacatagcc agaataatct cctaggaatt cttgtactac tgaaccactt cgacactgat   1130640
catggtggta aagcgtaatc ccttgtttct ctgctttacc tgacaaaaaa gtccaatagt   1130700
aagtcagctg actatcactc tctagcaccc tataagaagt ttcatccgca tgaagtaagg   1130760
gctgagtcaa tagtctctct cgcaagaggt tataaagggg ctccaaatag tattgactcg   1130820
ccttgatatg ccaattagag atttccttac gtgtgattgg taaacccatc ctagcccaat   1130880
cttcttcttg gcgataattg ggtaccttca gattaaactt ctgatggatg gtgtgagcga   1130940
taatagaagc tgagccaaag ttatgcgcta aaggggcttt aggaatagga gatttcacaa   1131000
gcttatccag atgattatct tttactcgtt atggacaatg ctatatggca taaatcaagt   1131060
accttaaaga ttccgactaa tattggcttt gcatttattc ctccatacac accagagatg   1131120
aaccccattg aacaagtgtg gaaagagatt cgtaaacgtg gatttaagaa taaagccttt   1131180
taaactttgg aagatgtcat gaatcaactc caagatgtta tacaaggact ggagaaggag   1131240
gtgataaagt ccatcgttaa tcggagatgg actagaatgc tttttgaaag cagatgagta   1131300
taaaaagaaa gtcctcattt caatagaaat cacgactttc tgatggattt atagtaaaat   1131360
gaaataagaa caggacaaat cgatcaggac agtaaaatcg atttctaaca atgttttaga   1131420
agcagaggtg tactattcta gtttcaatct actatatttt tggagtgata gaaaagccct   1131480
tcataagcca gtctacttgt tctggtgtga gagctttgac atccttttct gtacttagcc   1131540
aaatcaatct gccgttctca aagcgtttat atagtagcca aaatccttga ccatcccagt   1131600
aaaggacttt aaagcggtct ttacgtccac cacaaaagag aaagacttga ccggagaaag   1131660
gatccaattc aaagtgggtt ttaaccagat aagccagtga atcgattcct tgtctcatat   1131720
cagttttccc acacacgaga tagacctccc ctaggctaga tagatgaatt gtcatagagc   1131780
aacaccttat ccaaaagctg ttctaccatt tcgagattga gagattgaaa aaaacttact   1131840
tcaagcttgc caatacgaat tttaagcaga atatcatttc tctttttaga atcaaaacga   1131900
cgagattgtg gaatctctac aggaacaata ggttgtggca ttaaaatatc ctccaatagt   1131960
tttactttac taatagtata caggaggagc tccatgaatg atagatacct tgttatgacg   1132020
cgcttacttt ctatataatt acatttacga tttactaatc ctaaatctag attagtagaa   1132080
acattttcat tatctaacaa accaaaattt tgaaaaagat atcctgatac tgtcaataaa   1132140
aaaagcttag aaaggcttaa agccttatcc aagctgatat ttgttcatct aattaataat   1132200
ctaaataaag gatctacttc actttcataa tacgaactaa attggctctt tctgcctcct   1132260
ctagtttcaa ttctatataa tgaatagttt ccgacaagtt tggaataatc gagtattcta   1132320
aaccatttac acgtctacgt gttttttcta tttcatcagc cattaactga cacgtttttt   1132380
caacttctgc cagtcttagt aatttataaa ttaaactatt cattgtagca aatacatcat   1132440
ccatttcact attagaagat aaatagctgt attcactgtt ctcattttga gaagtaatat   1132500
tcatatgcat tctaggaact gttacactca tgatattttc tttctcaaca aataattcaa   1132560
tttctttcga tggaattgaa aataattcct ccaccatttg agaattcttt aatgatttag   1132620
caactgcaaa ggattttaga ttatcaatta gataactttc cacttctttc cgaagttgat   1132680
tattctcacg aatcaaagaa ataaatcgcc tcatcaattc atctctttta tcctttaata   1132740
acttatgtcc acgttcagct gttgtcaaac gttcctttaa gttattcaat tccatacgag   1132800
ttggttttac attcaaacgt accatagata atcactccat ttccggatta aacttctacc   1132860
aaaggtaagt atttatcaag caaatcatct ttgatacgtt ttaactctgt tctaggaaga   1132920
attgatagta attcccaccc aagattcaac gtatcttcta tatttcgatt tttataaaat   1132980
ccttggttta tgtactcttc ttcaaaacgc tttgtaaacc tcacatacaa tttatctaca   1133040
tcagataaag ccgattctcc taatactact gctaactctt caaccttttt cccttgggca   1133100
taggctgcaa acagttgatt catagttgga gcatgatctc cacgagtttt accttctcca   1133160
gatcccttat cttttaatcg agagagagaa ggtaaaacat tgattggtgg acgataacct   1133220
tgattataca actcatgcga caaaataatt tgcccttcag taatgtatcc agttaaatca   1133280
ggaattggat gtgttatgtc atcttctggc attgttaaaa taggaatctg tgtcaccgaa   1133340
ccttttttac caactaagcg accagccctt tcgtatagag ttgataaatt tgtatataaa   1133400
tatcccggat agcctcgtct ccctggaact tcacggcgag ctgccgagac ttcacgtaac   1133460
gcttcacaat agttagtcat atccgtcatg ataactagaa cgtgcatatc tttttcaaaa   1133520
gctagatact ctgccgcagt taaagcaatg cggggagttg caatacgctc aattgcagga   1133580
tcatttgcca agttcataaa taaaaccgaa cgatcgatcg ctcctgtttt tctgagttct   1133640
tccataaaaa actcagcttc ttcaaaagta atacccattg ctgcaaatac aaccgcaaaa   1133700
ttttcatcag aatttaaaac agtcgcttgt cttgctatct gagcagctaa ttcattatga   1133760
ggtaagcccg aacctgaaaa tactggtaat ttttgaccac gtacaagagt attcaaatga   1133820
tcaatagagg agatccctgt ctgaataaat tcatctggat aatctctaga tacaggatta   1133880
atagcttgac catcaatatc taaatatttc tctggaatta aatctggtcc accatcaatt   1133940
ggttttccca tcccattaaa aatacgacca accatatcct cagatacagc caattctaat   1134000
gcatgaccag caaaacgaat tttagacttt tctaaattta ttccactaga tccttcaaaa   1134060
agctgaacca ttgctttatc ttcgtggatc tctaaaactt gtccacgacg aatttctcca   1134120
ttatgaagtt gaatttcaac taactcattg taagacacat tatttacttg ttcaacaatc   1134180
ataagaggcc caacaacttc actagcagtt ctgtattctt ttataacact catttataga   1134240
cctcctgttt ctaatatcaa atgaatttga tgtgtaatct catttgatat aattttgatt   1134300
tcatctaatc tatcttctga aacatattta cttctcgcca tacggtctcg aactgccacg   1134360
gtaccttcca taatctctgt aaagtaagaa cccaactcta aagcatgatt tgcctgatca   1134420
gcaaaagtga gaatattact tagcattgct tcttgttttg caaacgaagt gaatgtatct   1134480
accgaatcaa aagcgttctg ttgcaaataa tcttctcgaa tttgtttagc aatttccatc   1134540
gttagtcgtt cattatcaga cagagaatca attccaacaa gacgaacaat ttcctctaaa   1134600
ctagattccc gttgtaagta gttcatcgca cgagttattt tactattcca atctgtcttc   1134660
tctttaccat ctatataagt gcccacactg tctttatata gtgaataaga tgtaagccag   1134720
ttaattgcag gaaaatgacg tcgctgtgcc aacggagcat caagccccca aaaaactttc   1134780
acaatccgta aagtgttttg agtaactggt tctgaaatat ctccaccagg tggcgataca   1134840
gctccaatag cagtaatcgt tccttcacgt tctggaagcc ctagaacctg agaacgtcct   1134900
gctctttcat aatattcagc gatacgactt cccagataag caggataacc ctcatcacca   1134960
ggcatttctt ctagacgtcc tgacatttca cgtagcgctt ctgcccaacg tgaagttgaa   1135020
tcagccataa tggcgacaga gtagcccata tcacgaaaat actcagccat ggtaattcct   1135080
gtataaattg aagcctcacg agcagcaaca ggcatatttg aagtattagc aatcagaact   1135140
gtccgttgca taattgattg tccggtatta gggtcaatca actcaggaaa ctcattcagt   1135200
acatccgtca tttcatttcc acgttctcca caaccgacat aaataacaat atcaacattg   1135260
gcaaatttag ctacttggtg ttgtacaact gtctttcctg ctccaaacgg tccaggaact   1135320
gctgcagctc cccctttggt tactggaaag aatgcatcaa taactcgttg acctgtgatt   1135380
aatggttctt ctggaattaa acgtttagaa acaggacgcg ccttgcggac aggccatttt   1135440
tgcataagcg ttcctttata gaaactaccg tccaattttt ttatttcata tacaacttca   1135500
tcaattgtaa aatcgccaga tgcaatagaa acgacttctc cagatactcc ataaggaacc   1135560
ataattttat gattaactac ctcggtttcc ttgacagttc caagaatatc acccgtactc   1135620
actttttgac caattgctat agtggaatca aaatgccact taatatctct atccaaactt   1135680
ggaacttcta ccccacgaac tagaaaatca ttatgagtag ccaatttaaa tcgatctaat   1135740
gggcgttgta tgccatcaaa catttgagaa atcaatcctg gccctaattc aaccgagaga   1135800
ggttctccag ttgtaacaac aggttctccc ggaccaagac cagatgtttc ttcatagact   1135860
tggatagatg cctgatctct tctcatttca ataatttcac cgattaaccc tagcttacct   1135920
acacggcaaa tatcttgaat attagcctcc tgcatacctg atgcaataac tagaggtccc   1135980
gatactttta taatcttccc ttgagtcaaa gttattctcc ttactaagtc caaaaattat   1136040
agaataatat tacagacaat tttgtacatt attataaaat attgtgtcct actgctttct   1136100
ctacattatc ctctatacgt tttaatccta aatttaaacc ttgtttatga gtcggtaata   1136160
aaataatagc aggcacaact tgggaatcat aatggcgaat tgtatctaat atcattgaag   1136220
caatgtcttc agtgatataa atgacaccat aatcagattg agctaatttt cttagtgtat   1136280
ttatagcttc ttgttcttgg taggcaggaa atatatcaaa cccaatcatg ctaaatggta   1136340
aaataatatc acggctacca attatgccaa ttttatactt attagcttcc ataatgtggg   1136400
cgtatccttt cttttattga ttcaaaggga attgtatttt gaagagctga tatgatcatt   1136460
ctgagattct ttacttcaaa ctcacatccc aataaatatc tagcaagaac taacggcccc   1136520
tctacattgt accttccttg atctaaagtt ttatacaata gtaaatcaca taaaaattct   1136580
aactcagaag atgaaattgt tgcgtcctgc atcttcaatt cataagttga aaagattgaa   1136640
tctaagcttg gatttatttt attgaaccac acaaatattt cttgattttc tacaatgtat   1136700
ataaattctt tagcagaaat acttccttca tctgaaagta attgtaaaat atccccatga   1136760
ctcttatttt gagataaacc acgttttaca gtaataatat tataaaagtc aatcatttcg   1136820
acaataacct gagacagtac ctcatctaac tcattagata aaagtttcag atgtttaaaa   1136880
tatgctagat cagctccgac atcaagtaca cgaatattat taaaagtttc atactcattc   1136940
caaattgatt ctacttcacg aaccataaaa tcaggaagtg tatctgaatg taaggaagaa   1137000
actaaatgtt ttaaactttc tatatcaaaa atccctattg gaattaataa tttagaaaaa   1137060
tctttcttaa ttgccgcctt agattttaat aaaactttga tattatgata aacatatcgt   1137120
aaagcaaata aagtcacaat tatatcagac ggactttcag cataggccca tctataatca   1137180
ttgactaatt ttgtcattag cgaaatctct gtctgactag gatcttctaa gatgtcaatc   1137240
gataaatgat agggagttga ttctaagata aatgccaatg tctccgtatc tttggattgt   1137300
ataatttttt gaaatttttc ttctgtaata aaatcgtttt cttttaccga aatcgtcgta   1137360
tttatttttg aaaaaagatt agtatccata aaataccttt ctaattttat tggaatactc   1137420
caaatttcta agaaggatta accaatttca tccttaattg ataaaaattt gatttgcgat   1137480
acttgaactt tcttccttag aaatcgatcc aattaatgtt ttatacaaat agttatcatc   1137540
aattttacct attgaaataa gtaagcctga ttcatttgag ataggttgtt cactaaataa   1137600
ataatttgga aaagagaatt tcaatttctc taattgttcc aaattgaatt tagctaaagt   1137660
ccgttcccca aaggttacta tgacctcttg ttgtgaatat cgttccagaa ttcgatagat   1137720
gaactccatt tctttatctg cactccaaga ttccatttct agtaaagcag attgaaaaag   1137780
ttcttttaat attttctgtt ttgatactaa cgttgattgg cgttccttat tttttaattg   1137840
ttgaaaaatt atttgatatt tctgttgcaa ttcttttaac tttcgttcat gttcagcttc   1137900
ttttttcttt ataatgagcg acttttgcat ttcaaattca tcatcaatct tctttttgga   1137960
atccaataat ttcatacgcc ctttttcatg agcttgttca ataacagact ctcgtaagtt   1138020
ttctaaattg ctcatttaga cacctccttt gaattgcaaa tttatttctt atacacgaag   1138080
ggtcaaaatg aatgatacga caaaagcaag aattgcatag gtttctacca tggcagctaa   1138140
aattgctccc ttcatgaatt cttttggtct tttagccaag atttgcattc ccgctactgc   1138200
tacatttcct tgatgcttag ctgaaaagta tcctacaata gcaattggaa gagctacaaa   1138260
gaaataagca acgccttttt ctaaaggaag ttctggagtt aattgcaacc aaattaaaat   1138320
tccaataaca aaaccatata atccttgtgt tccgggcaat aattgcaata tcaaagctga   1138380
ggcaaacttt tcaggctgtt ctttcagtaa agctgcggca gattgcccag ccttaccaac   1138440
tccataagca gaccccatac cgcttaatcc aaccgccaat acaattccca atgcagcgaa   1138500
gaaagctcct ccataggttg aaaaataagt tgctaaatgt tccattatat atatcctcca   1138560
ttaattcttt gtaataacct taatatattt ctcagaagcc ttcaaaggtt gaaatggttt   1138620
tcctccaccc tcataaaact taccaaaaaa ttcaacaaat atcagacgtg ctccatgaac   1138680
atatcctgat agtaacgata gaaaaatatt gatcgcatgt aaaagaatga ataatactaa   1138740
tccaattgtc agtttagcca atattcccgg aaacaaacca acaattaaat tgaaagctga   1138800
tgctatactt gctccagata atcctaatgc catcaatcga gtgaaactaa ctaaatcacc   1138860
tatataagat gaaatgttat atagattaaa caatcctgct ccaatacctg acaagctttt   1138920
ggtttgaata atagaaacaa tcaaaatccc cacagcatta aaaatagata cccatttccc   1138980
taatacaaat aacggtctca tatcaggcat caacattcca acagcaataa ataacaagcc   1139040
aagcagaata acacaccacg caaatcctga attatatgct tctgcatatt tattcattct   1139100
tactttttgt agtcctgaag ctaacaaacc tgcaaatact gtaataaacc caaacacaac   1139160
tgacactact aatatagtca tgacatcaga ggttgtagat atcagatgaa atggcaactc   1139220
atatccaaaa aatgagccat agattccacc ccaaattgca acggctaccc ctaatatatt   1139280
aaagaatttt aaaaatctct tagttgctga aggtagatga aaaattttta atgctaacat   1139340
tgttcctaaa aacaatagta aaccatagcc taaatcagca accatcattc caaaaaatgt   1139400
aaagtaaaat ggtgctaata caggtgtagg atctttctca taatatttgg gcagagcata   1139460
catttctgtc aataattcaa atggttcaat taaagaatga ttcgttaatt tgataggtat   1139520
ttcatcttga ttatccgtca atgtttccga ttcataaata taaatagaat gtccaaaatg   1139580
ctcatccata acttttataa aatataaaat acgagtttct tctatccatc cttctaatgc   1139640
aactagatgc ggagtgcaca aaaagttatt cttagagatt tgacgagcat agatagataa   1139700
aatatagtct atttgccatt gtaaatctat caaatatttc tttgaatctt gcaacgatgc   1139760
gataatattc tctttttcag ttattaactg catgttttct tgatctaaat ctactactcg   1139820
ctgcttcggt aattcctttc tagaataatc aaatggttca aataagtatt catcaaaatc   1139880
tatagagtaa ctagactgat agaaaacaac aacaccgtac tctctatcat tagaaaatat   1139940
ttcttgaact tcaatattgt tttctaaaag actattgtat aagcgattat cttcagtcct   1140000
tggaattgtt ccgacttttc ctttacagaa agaaaattgt tctaaattcg caggaacaat   1140060
ttctaatttt tcccacttta ttaatcgctc tatttcctca ttattacttt gaatgtgtct   1140120
ttctaattca tgaactctgt taatttgatg attcactttt ttaagaacac cctcagcaac   1140180
attagcttta ccaaatttct ctaattcttc ataagaggta gttatcggag gttgctgcaa   1140240
taatttaaac gtgttttctt tcggtaggta ttcttgtaat ttctctacag ttgcttctaa   1140300
atgttgttgt tgattcatca aataagtcaa ggcatcattt ccctcaataa ccccatgatt   1140360
ggaattagaa gtatgaaaaa tttgaatagt tggaaataca acttcatctt tttctagagc   1140420
ttctgaccag ttatcctgaa cctttaaatc acggaactgc actgactcta gttcttgaat   1140480
agtttttaaa acatcatcaa gactactttt agaaaatagt agagagattc ttttcatctg   1140540
actaatggcc atatttttct accaccctac caataatttt ttctacaaat tctcctctcc   1140600
tacttgatga aatatactga atatttgcat cattttcctt gattgtttta ttaacctcat   1140660
caataaggtt ctgttgtttc atttctaaat tgctttctat tgaaactaat tcttcgtgac   1140720
ttttttcatc ataacttttt tctagttttt ccaattcttc ttgggaaaca gctttataag   1140780
tataaatctc attatcatat gattttataa tatcggttgc aacattctca atatcttgca   1140840
ttgtcgaaaa tacagagtta gtcattgtga cacctcctta tcttacatac tatttattag   1140900
aaattctatc taagaaattt tttacagctc ctatacgacc agcttcattt cctaatgtag   1140960
ctgccacaag atttttaggt aaaaacctat tatccattgc atttttagct aaagaacttt   1141020
gaatttcagg taacaaaata tccttactat ccagaatccc acctcctaat atgagaattt   1141080
ctggattaag tagataagaa atcgttaata aaccttttgt tagattttct acaaaaattt   1141140
caaaagtttc ttcagcaact ttatctccag atcttaaatc agtgaagaaa gtacgtccag   1141200
tttgattagt tttcaagctc tttttttgat ataaatgaat caatgcggtt gttgaggctt   1141260
tactttgcca atccgaatta cctacaggaa tataacctac ttcaccagca gtatagttaa   1141320
atccgttaac aatttgtccg ttgacaataa tactgcctcc tatacctgtt ccaatagtaa   1141380
ccattactac atttttctta tctttggctt gtcccttcca caattcacct aatgcagcac   1141440
aattaacatc attttcaaca aaagtataca acccaaaacg tttttctatt tcggcagtaa   1141500
agtttactcc gatataccct ggtattgtat agcctgcata gatgatttct ccagtattag   1141560
cattaacaac tccagcagtg gaaatcccaa caccatcaat tgaatgattt aaagtatact   1141620
caccaattaa atcacagacc tgatttaata tctgattcgt tcccaaatca tagtcaataa   1141680
ttgtttctat ctctttgaaa tgattcaaac tcgttccaaa ctcatcgtat aaatctgcct   1141740
taattgttgt tccgccaata tcgataccta taatcttcat ttcaacactc ccacattttt   1141800
gatctcatta ctttttgata aaaaatggga ctgggcatta tcccagtccc atctctattt   1141860
ctttattcaa tgagttgtat cacagaactt tagaaattat ataatgacaa gaatttacta   1141920
ttctgtttta caaaagttaa gcatttgtga tttctgaaag acttactttt cgatcttctt   1141980
taactgataa agtacatgca tcagcggtag cgattgattc taaagcagct acaccattga   1142040
gaagtttttc aaattcttct gtaatttctc cacctttaat gatgtcatgt agatattcca   1142100
tttctttatc aatacatgtt tgcaaccata atgggcaacg tactcctggt ttaccgtacg   1142160
caattgctcc atccatacca cgaccggtat agatagctgt acgatcatca tcttcctctt   1142220
gagtttcatg aactaagaag tgtgattctc cttcaccttt aacacgaaga gtaccgccag   1142280
tattgaacaa gtcaagtttg atagctcctt cagttccttg aatcaagacg tagtgttcac   1142340
cccaacggaa agcattacca tattccaaaa cagcataacg atcatcagag tattctaagt   1142400
ttacaatgag catatcatct tcatcaccaa agttttcacc tttatgatat acattgcctc   1142460
ctaccattgt cgctttttca ggaagtcctc ccatgataaa ctgaatgcaa tctaattcat   1142520
gaatatggtg gtacaaatgt cctccagatt gagaacgaag tttcttccat gatacagttg   1142580
gttgttgttc ttcccaacct gtacgagcag catggcaata aagaacttta ccgattttac   1142640
cttgagtaat caattcttta gcatggtgta caccgttaaa gaagttcatg atgtgaccag   1142700
ccataaagat gacattattt tctttacatg cgtcaaccat ggctttacaa tcttcataag   1142760
acaatgcaat tggcttttca caaaatacgt gtttgccatg ttgagcagct ttcacaactg   1142820
gttcacggtg aaggtagcta ggtgaagcta cgatcacaca atcaatatct tcacgtgcta   1142880
caagttcatc taaacttgca caaacatctg atcccaactc ttgagcaact tcttctccat   1142940
gatttgggtc aaataccgca accacttttg catcttcaat tttgttcatt gagcgagcta   1143000
aatcagctcc aaaatatcca gctccaacaa taccgtaatt taccataatt tttatcctct   1143060
ttttatatat tttcaaattt cagctttaat tctttttcag atcttcaatc ttaaatgtta   1143120
tatatggtac aacatttttc atatgaagtt cattacgaga ccatgaatca aatttttcaa   1143180
acatcaatcc aatttcatga tttggtaact ctgtcaatgt tgaatatgag tatccatagt   1143240
tactataatc aacgtcgtga tgataacgcc aatcaattgt attatcatca ttaattagac   1143300
caatccaaat ttgtccgtgt ttacgaccat ttgtggagtt tggagtactt aaaatgacag   1143360
cctttttacc atcaatcaat tggctataat tgatgattga taattgtgtt ccataacttg   1143420
gatttgaaac aaatttcaaa tattccggtg cactccaagt agtacctgcg tctttacttg   1143480
ttaaatatgc aattttacca ttatttgtac gcatatatgc ttgaattact cctggactca   1143540
attctacaaa ttgtgcttct gctgaccaac tagaaggaag tggcactact ttaactttcc   1143600
aagatgctcc attatcgtca ctataaatga acgcagactc tttaccagtg taagacggaa   1143660
taagaatacg tccagttgag ctttcaatga ttccacgtcc aggacctaaa tatggcgcat   1143720
tccgattaag tcccattata ggaggtaata aagttggtgc agaccaagat tcgccatgat   1143780
cattgctaga aatatatgca atatagttcg ttggcactac tttaaacaat gcatctttgt   1143840
agaagatatt catatggact ttagtcccat tacgatattc agtcttttta ttattttcaa   1143900
atgaaaccga atattgctct accgtcaaat aattaccatt ttgtttaata ccgaaatttt   1143960
tatctactga aaattcagtt ggtctgttgg tacgatcgtc gtatacagta ccattctcac   1144020
gaatagtata attgtaatca gtatcacctt gtttccttaa tttaaggtaa taattaccat   1144080
caatttgttt ataacctgaa tcttttctag ttgcttctct aaaacttact ccagcaggca   1144140
tcacatcagc aaacatgagt acttgtttgt tctttttttc aacaataaca gagtcaatat   1144200
aggttgcacc accgctgatt tgtaagtcac gtccaccaac ttcacgaggc cattctaatg   1144260
gtactggcgc aaaatcatcg aatgccaatg ttaattttgg tttagtccat gtcttaccat   1144320
tatcatcact ataacttgta gcaatattaa ttttattcaa gaaatcatga gttccaccgt   1144380
aacgagcgtc aatgcttgaa aatacccgac cattgctaaa agtatacaga actggaatac   1144440
ggaaatagtt agaacctgtt gtatcattag ccgtataaat taaatgtcca gtaacagcgt   1144500
ttgttgtcat ctttttaaca gtttcttcat ccaatgcact attaaagaat ttgatatttt   1144560
ctagtgttcc gttaaaacca aacgccgttt ttcctgcacg tttcactccc ccaagcatat   1144620
agtaatcaat acctttaata tccttgatgt ttaggaaatt atccactttc ttttctacta   1144680
cttttgtacc atttgcgtat aaagaatatg tttttttgac tgaatctgct actactgcaa   1144740
cagtgttagt cacagcctct tgtttgtact taccccaaac tgaagcaggt ctggatacta   1144800
ggttattttt attggaagaa gtatcacgcg cttccatccc caactcacca ttgtctctaa   1144860
ggaacacatc tacataacta ttttgttgac cgggtttgga attagatatt ccaaacagag   1144920
cttgtaagcc tttctcactt gactgattgt acttaatcac tacagtaaag tcaccgctag   1144980
taaatttatc ctttaactct ttagtaacat tttctccgcc ccctgttaaa gtaacattat   1145040
ttttttctaa gacaggagtt tcttccgctg tagaagatgg atccttaaca gtagtttcaa   1145100
ctgttcgagg ttgtacagta acttccgaag agttatccga tgtaggttgt acttccgaaa   1145160
tcggagtcgt tggtgcaaca ggttgcacca actttggtgt tgatacttca gaagtttcag   1145220
tctcctgagc tgcaactgag ttagcaacaa atgctgataa taccactaca gtacctaagg   1145280
ttacatattg tttaatattt tttttcattt tatttttcct cgtttaaaac tttgataaca   1145340
agttttttaa cagtttcatc attgcaatga atctttggtt ggtgaagatc ttcttcaaaa   1145400
gtcaccaaca tattccctgg aagcaattca acaatttgat agtctttgct atcgtaaaaa   1145460
gcaatatcct tctcttcgct aaaaggtaca cgtgactggg cacgaactgg ggaagttact   1145520
gccatttttt cagtattttc aacaacaata tgaatatcta aatatttctt atgagtttca   1145580
aaaatatctc ctggaactcc atcagctaga taagtcatac aatttgcaaa aacattttcc   1145640
ccgtcaatat caatttttcc atcaactaaa tctgtcaaat ttgtattttc taaaaaatca   1145700
cagacttttg aaaaatattt attgacagaa gcatatcgtt taaaatcaga ttgttcagaa   1145760
ataatcatat tattttctct tttctattag tgacgaactt cccaacttga atccgcttta   1145820
atttctgtaa tatcatgaat cgttgtatat ttaggtgcag atactttatt tccagtaaga   1145880
acagatacaa tataacctga aactactgat acagagattg aaatcaatga atatgcccag   1145940
tagctaacag ctgttggagg aaggaagtat ttaataaata ccatgacgat ggttgataca   1146000
atcagcgctg cataagcacc ttgtttattt gcttttttag aaacaaatcc aagaataaat   1146060
acaccaccaa gtagaccaag tacaagtccc atgaaactat tgaaccattc gtatgcagat   1146120
ttaatatctg agtgagccat gacaatggaa acaccaattg agaataaacc tactgctaga   1146180
gatacgaatt gtgcaatttt cgtacgacga ttgtctgaca tatttttaga aatgacatct   1146240
tgaatatcca atgtccatga agttgcaaca gagttcaaac ctgttgaaat agttgattga   1146300
gatgctgcat aaatcgctgc caagatcaaa cctgtgatac ctactggtaa ctggtatgca   1146360
ataaagtaca taaagatttg gtcttgaggg atattgctag ctgcactatc tgcattttgt   1146420
acttgataga atacgtacaa gcctgtacca atcaagtaaa agactgttgc agttgcaagt   1146480
gacaaaacac cgtttgtgaa caacatctta ttaagtttct taatattttg tgttgtagta   1146540
aaacgttgaa ccaaatcttg agatgaagca taggaagaca agattgtaaa gcctgaaccc   1146600
atcacaatta aaaagatgga gtttgaaagc aagttaggat cgaaaagttt ttcatttgca   1146660
gcaaggaatt tcccgtttgc taatgtttct gctactgcac caaagccacc tttaatatta   1146720
gcaatcagta caaataaagc taaaacgaca ccactaatca gaatcacacc ttgaataaag   1146780
tctgtccata atacggattt tagaccacca gtataagaat aaacaattgc aactacaccc   1146840
atcaaaataa tcaaaatatt gatgtcaatt cctgtcaata ctgataaacc agctgatggg   1146900
aggtacataa tgatagacat acgtcccaat tgataaataa taaacaagag tgctgaaata   1146960
atacgaagtg ctttagaatt aaaacgttta tccaagtaat catatgccgt atcgatgtct   1147020
atccgtgcaa agataggtaa gataaaacga attgtcagtg gaatagctac taccatccct   1147080
aattgagcaa accataaaat ccagctacct gcataagagc taccagcgag tcccaagaag   1147140
gaaatcggac tgagcattgt ggcaaaaatg gataccgaag taacatacca aggaaccgaa   1147200
ccatctcctt taaagaactc ttttcctttc atctcttttt tagagaaata gatacctgca   1147260
accaacaccg caagtaaata aacaatcaag ataattaagt caattattgt aaatcctgtt   1147320
gtgcccataa catatctcca tattgatttt atttattata aaaattcttt tcgtgcttgt   1147380
tgaataagtt ctgctgcttg ttttgcaact tccaagtcac cttctgccaa tgcttctaaa   1147440
ggttgacgaa cagaacctaa atcaagtttt tcatttagac gcaaaacttc ttttgctaca   1147500
gcatacatat ttgccttacc tgatatcatc ttatagataa cttcattgat agcatattga   1147560
agttttttag ctgtatctaa atctcgttct tgaatcaaac tttccaattt caagaacaaa   1147620
tctggcataa cgccataagt accaccaata ccagcttctg ctcccatcaa gcgaccacca   1147680
agatattgtt catctggacc attgaataca atgtaatctt ctccacctgc agctacaaac   1147740
atttgaatat cttgtacagg catagaagaa tttttaactc caatcacacg aggattttga   1147800
cgcattgttg catacaaact accagtcaac gcaacccctg ccaattgtgg aatattatag   1147860
ataataaaat ctgtatttga cgcagcttca ctcattgcat tccaatatgc tgcgattgaa   1147920
tactctggca atttgaaata aataggtggg atagctgcaa tagcatcgac tccaacactt   1147980
tctgaatgtt ttgccaattc gatactatct ttcgtgttat tacatgcaat atggttgata   1148040
actgttaatt tacctttagc aacttccata acagcttcaa taatttgttt acgatcttct   1148100
acactttggt aaatacattc acctgaagaa ccatttacat agataccttt tacacctttg   1148160
tcaatgaaat attgtaccag agattttaca cgatcttggc taatttcacc attttcatca   1148220
tagcaagcat aaaatgcagg gataacgcct ttgtatttag ttaaatcttt catcagattt   1148280
ctcctttata ttgtttttta tttgatgaca ttaataaatc gctgagcaat ttcttttgga   1148340
cgtgtaatcg ctccaccaat gactacactg gtaacaccta aactataagc tttttttaat   1148400
tgttctggat aatgaatttt tccttcggca attaccggaa tattaaaatc agccaatttt   1148460
ttcattagtt caaaatcagg ctcatctgat tgtacacttg tacttgtgta acctgataat   1148520
gttgtaccaa caaaatcaac gcctgattta aatgcataga gaccttcatc taaattactt   1148580
acatccgcca tcagcaattg attcggatat ttttctttta tttttttgat aaattcactg   1148640
acaactaagc catcatatct tggtcttaaa gttgcatcaa atgcaatgac tgttgttccg   1148700
cattctacaa gttcatctac ttctttcatc gtagcagtaa tatatggttc ttgaggtgga   1148760
taatcccttt tgataattcc aattattggt aaatctacta ctttctgaat tgctttaata   1148820
tcacgcacag aatttgcgcg aatgcccact gctcctgcct ctaaagctgc tttagccata   1148880
aaaggcatca agctaaattc ttcattataa agggcttcac caggtaaagc ttgacaagaa   1148940
acaatgactc caccttgaac ttggcttata aatttttctt tagtccaaat ttggctcatt   1149000
ttattattcc tccttatgga taatagtttg attgtaataa tattgtctct ctggactttc   1149060
cagataatta gagaataagc agtctgtaat taaaagtatt ggaaactgag gtgatatgcg   1149120
attgccatac gagagatgat cggtcgaagc taataacaat agttcatcaa agaaacaatc   1149180
ttcttcgtca aattttcttg tagtcattaa aactgtttta gcgcctttat ctgcagcttt   1149240
ttgtagacct tctagtacaa tatcagtttg acctgaaatg gatgctccaa tgacaaggca   1149300
attttcatta agtagtaagc tactccacaa aatcatatcc tcgtctgata atacttcacc   1149360
aatcactccg agacgcataa atctcatctt catttcttgt aaagcaagaa cagaacttcc   1149420
tttaccgtag agatatacac gctcagcagt ttctatcatc tcagcaatac gctcaagttg   1149480
aacttcatca agaaccgtgt aagtttttct caacatttcc tcatagtcgg ataaaacttt   1149540
ttctgttgcc tctgtatata atgccaactt ttctttctca tgaatcatct cttggtattt   1149600
gaaaatgaat tgtctaaaac ctttaaaacc acattttttc gcaaatcgag tcaatgttgc   1149660
tttggataca ttaaggtatt cgcacaatgc tttagatgaa taatcattca gaggttgctg   1149720
ttttaagaag aatttagcaa tgtctttttc agcatatgcc atatttggta agttagcttc   1149780
tatcattgga attagttctt tttgcagtaa catatgagct ccttagttga agtaaacgtt   1149840
tacattcttt attttaacac tttttttttt tttcaatatt tttcataaat tagaaactag   1149900
tttccaattt ctttcgtttc ataacagaac aacaaacata aaaatataat agtttttatt   1149960
ctttttatcg taattatatg tattgtaaga acgtttatca ctaataatat gttcatatta   1150020
aaatatttta gtaatatttt attttggttt tattatttct tttcggaatt tctatataat   1150080
attttatttc taaaaaaatt gaaaaaatat ttctagtttc tttattttat ataggtaata   1150140
tattttattt ctaaattaaa agagaatccc ataaaaacta cagatttatg agataaatca   1150200
ggtcacctat tttaaaaaag cagcaaacta taaactaaaa agttccacac caaatgtaac   1150260
cccatacttc cccataagtc agatttatag cgcaccatac ctaaaaacat tccaagtgaa   1150320
acgtacagac accaagctag aatggttcct ggatgatgta ctaaggcaaa taaaacactt   1150380
gtcaaagcaa ctcgaatatc taattttcta accaagttcc ataaaatttc acgatacaga   1150440
aattcttcaa ccatactcgc attgattaag aacaataaaa atgaaaacca aggaacttga   1150500
tgttgaaggc caattaaatt tgtttgattc gtgcttcctt gagcatgaat caggctaaaa   1150560
catagactta taatcagtag actagctagt ccaataccaa ggcatttcat cctagttttc   1150620
atattgacct tgaccacttg ttttcgttga ccatacatcc ataaaaaaga aaaaagagac   1150680
gcaccataga gaacctgtag tatagttaac tcaccgatac aaagaaattt caataagtat   1150740
agagatacca ataggacatt tacttgttgg aatatataaa ctggaattat tcttttcata   1150800
gttacctccg aaataaatct tcataatcta aatctaatat ctgcacaatc ctttctaccc   1150860
atggactttg aggcattcgt tgttccatct tgtagtggcg aatcttttga tataaacgat   1150920
tcaattcact tggatagtga aactctcccg caaacatttt tctggttaac tcaatccagc   1150980
tgatatttct ttcagccaaa ataatggaca agttctccca aaatcgttca gccatattac   1151040
ttctccttta gttagataaa taatgtgttt gtgccatgta aatcaattgt ttcgtatctc   1151100
ttggcaatag agctctagcc tcttccaaat tcagacttgg ataaacccgc ttatttgaaa   1151160
ccacaaaagg aagtccgatg gttagttcag gattttttaa aattatctca acgaaatccg   1151220
ttaatcttag attgtcacgg ttcttaaatc gtaataaatt gggagataaa aactcaaaac   1151280
aatctgaaga atagctcatc atctcaatta atttgtcctt tgtcatttca gaaactgaat   1151340
gacaagatac ctcaatgcca tagttttgga agaagtctaa aagaagttga tttctttggc   1151400
tatttttact tagatagaga tcaatcatgg gagacctcca acaaatttgc ttccatttga   1151460
tattctgaga cgattaagga atctaacaac tttgagaagt taatcgattt cttgtcttca   1151520
tcataagctt ttacagttac ttgggttgta agtatcccct cttttccctc ggctcgatag   1151580
tcttgtcaat ataaaacaaa aacaagattc tgattatcat ctacaaaggc attaactccg   1151640
ttctttatat cctgactttc aaggaattcc ataacgtttt gaagatagga ttcataaaat   1151700
agtgggtaat tatgtttttt atggtaatca tctaaaaatg ttacctcaaa ctcacatgga   1151760
taattgggca tcaaaaatat ttgttcatcc agctgtttga tttctgcatc atgtaattct   1151820
gtttctaatt catcacaatc tagtattgat tctttattta atgcttttat ctttttcctc   1151880
tatttctttt aatttctttg cgattgcggc aatcacagga acggttacac tattaccaac   1151940
ttgtttatag agctgactat taatagagac ttttctagca gcttcaaaag cctaatcagg   1152000
aaagccatgc aatcgaaaac actctttagg agtgattcgt cgtattctca aacggtaaaa   1152060
ttgtccatct attaaaacac cagctacttg gtaaacttgt ttatcttctc cttcatagct   1152120
agccactact actcccattt gaccactagt tgttaacgta ttagctatac cttttccaac   1152180
tctaccacga cgatactgag aacttggtct ttctaaattg attgaatccc caatctctgc   1152240
ttgagcatat ccttttttcg ttgcttcccg tacttttaga aattggattg gttctggaat   1152300
tagtattttg gggattttat ctcctccttg catcgtagtc agtgttggag ataagccctc   1152360
acttccatag acacgacctg tctccttaaa gctagtcggt aaatctccaa caacgacaat   1152420
gccataacga tcctgagtat ttaaagtaaa catcggctct tgattttcct taaagcgtct   1152480
cccattttgt ctcttgtcta atctatctgg tgtcatacaa ggaatcgcaa ctttaaatcc   1152540
ttctccttta ccacgaacta aggttggcgc aagaccttct gaataataga ctttaccgct   1152600
cattccactt cttgatggat tcaaatttcc tagtgctttc aaagtctcag agttagttgc   1152660
ttgaccttct cgtctgaaag gaaataagag tctggtacct ttctttctag aatgtccgat   1152720
aataaacacc ctctctctgt ttttgggaac gccaaaatcc ttactgttaa gcacctgcca   1152780
ctcaacatca aaccccaact catcaagtgt ggtaagtatt gtggtgaacg tccgtccctt   1152840
atcgtgattg agtaggcctt taacattttc aagaaaaaga aaacgtggtt ggatttgttt   1152900
ggccgcccga gcaatttcaa agaacaaagt tcctctagta tcttcaaatc ccaatcgtct   1152960
tcctgcgatt gaaaatgctt gacaagggaa tcccccacag atgacatcga ctttccctct   1153020
aagtttttta aattcgtcat ctgaaacatc tcgtatgtca tgaaattcta tttctccttc   1153080
cgtttgaaaa atggacttat aagatttcct agcaaattta tcaatctcac aaaatcccaa   1153140
gcactcatgc ccttgagctt ccattcccat cctaaagcct cctatcccag caaataaatc   1153200
taaaacccaa atcattcata cctctctcaa ctagatgtaa cttacaaaac ccctgacctc   1153260
atgagccact ttcttcctcc tcatgaggtc agttttactt tctgctgttc cagtatcgtt   1153320
tttcctcgct agatttcctc aaaagggcag actcctccct tggttcgtca cacgattttt   1153380
tcatctcgac tgttctttaa tgcatcatta acgacgcttt tcttctaggt ggttcataag   1153440
gaacaggaag attcaggttg acttttctaa tcctagaata aagtgctgaa aacaattcgg   1153500
aataggcata gagactagac aatttgagga gctgcttgcg tcctgttcga acacattttc   1153560
ctaccacgtg aagaaaaaga tggcggaagc gtttgattgt taaagtttgg aagtcacctc   1153620
cagctagatg tttgagaaaa agatagagat tgtaggcgat acagctcatc atcatacgaa   1153680
cttcgttttt gattaaggtt gaactatccg ttttatcgcc aaaaaatccc tccttcatct   1153740
ccttgatgaa attctcggct tgaccacgtc cacgataaag ctgaaactgg tcttggcttg   1153800
ttccactcgt catatttgta acgagagaaa taacatcgta gaacaagttt ccttcttttc   1153860
gttcagagaa ctggcagaca cgacgcttgt gcgaccaaga tcctgcttga tagagagttt   1153920
ctgagtaggc ggagtggggc aagatggtta agtcctcatc ctgtgggcaa gggagggaaa   1153980
ggtctccaag acggctcaga acagtatttt tcttgagttt tatgaggtag tattgccctg   1154040
ttttttcaat taaatcgtat aattttgggg tcgcaaagcc actatccatt cgaaagagaa   1154100
gttgattaaa ccgttctaaa acaggtgtga taaagctgtc tgcctcttca gaacaataac   1154160
gattaccagg acgaagctgg gcattgaaac aataacctgt cttcccctcg aaagcataaa   1154220
gaggatgata gccatgagca cgatagtggg cgttataagc aacaccttct tgcttgccat   1154280
aagttgtgaa atgggtagaa tcgatatcta caatgagttg gtttagctgg tgaaactgta   1154340
aaaagaattc gaccaattca aggttgaggc atcgcaaact atggactgtt tcctcgtcag   1154400
ttctggaaag aaaacgggat aaggttggct gtgaagcaag ctgccctcct tccaataatt   1154460
ttggaaagta ggcatcagct gacaattctt tacaagcata gtccgttcca taacctgtta   1154520
acagttgaaa gaggaactgg acaaggatat ctgaatccga ataacgacag tagcggcgtt   1154580
ggtcattcgt tactaaatac ttagaaatcc gctcttttag tttcaactgg gaaaaaagtt   1154640
cctgaaaaaa gataagacca ccatactggg ttaaatgacc tccatcgaaa gatagttggt   1154700
aaaaagactt gttttggaag tgatgatttg gtaaactgtt catgtgagtt tcctttcttt   1154760
ttgtgttttt ttctacactt ataccataaa ggggaaactc ttttttgtct agtaaaaaac   1154820
acccattggg tgaaaaaaga aaccatccag gatctaagct aaggcaagga ttctggatgg   1154880
tttttagatt tggggtgaat aattggggtt taaaattgtc taaattcgac agaaggaagt   1154940
agcaagcatt gtcgctaaaa aaatgcatca ggttatcctg tgcatttttt tgatatcaaa   1155000
ataatcaatc tcctttatga gctaattctt ctctacaagc tctttggagc agaacaactg   1155060
taagtataaa aaccacacat aaaatcaaga tacttctctc agccccaaaa acaccactag   1155120
tatataaatc ttgacccgtt aaatttgtac tgaataaact aaatgaaact tttatcccac   1155180
tcactaatac tattatatca acccactaca gttgacaaaa agacaaacca gcctaatgac   1155240
tagcttgtct tcaatcaaga gaggattctg ttccccccat ataagcacta acattccaac   1155300
gtgcacatat tggaacgaca tccataactc cagagaatct ctaaagttta caatttaaat   1155360
gaattaacaa ttttcccaac taaaagcact ccagttaccg caacggtttg tactgaatgt   1155420
actaaatcgc attccatcaa cttcatctgt ttcgtcaact tgaacagata ctaattgaag   1155480
atttaatact tctgctgcca tagctagctc ctcctattta aatttttggg attaagtact   1155540
ttatccaccc tcatatactc tctccaccag taaaatgcaa gcaatgatac aaaatagatt   1155600
taactatttt atatagcgaa aacttacaaa tttttaagaa ataatttttg cattcttaaa   1155660
gataaaatag gaacttttag taataaatat taaaataaat aaaataatag atactataaa   1155720
atttggaagt attaacccca aaagattcat atcatctatt aaaatatcct ctaaagagta   1155780
gtatattaaa gccataattt taatgttaag taaaaatgca attaatgaag taacaaatgt   1155840
caaaaatata gcctcaccaa ctttaatctt aaccatctgg taattagaag ttcctaaaat   1155900
ttcaaattgc tgaatctcaa tcctttcttg atgcgatgac aaaaatgcaa ttgaaataat   1155960
atttgcaagt actatcaaaa ttggtgctcc tacatagaca ataaatgcta cttttagctc   1156020
taaatcactg tcatcttgaa attgagatag tatattctga gaaatcattt gaaaactaga   1156080
aattagtaat atagctcctg taattgcagc actgatagat tttatataag acttacaata   1156140
tagtaaattc cacttcgaaa caatgaacat aaaattattt ctaaatataa ttatagaaag   1156200
tagtttgata aaacatgact gtataaaagg agataattga taaataatca caatatctaa   1156260
gattacaata ttgaatatta tctgggcctt cgctaaaatt gtgctatctt ggaaaatttg   1156320
ttgcaaagaa agcaaccaga taacactaaa accagccaat agcagtattc tttttactat   1156380
tgaaagaaca tgccttattt tagaactctt cctatttcta atcttcttga acgtataaaa   1156440
gcaaccactt agaaaggcta aaaatgaaat caacactact gtaatgatac atccaacagc   1156500
actcgtttga aattggatat caggtaatat attttccccg aaaaagtatt gtaaaaaata   1156560
ataataattt gacgtaacaa atatagagca tagatatgca ataaaactaa taatcgagga   1156620
aatgataaaa atctgtcccc ccacaagaaa tgatagttga aggcgacttg ctcccaacac   1156680
ctccagaagt tcgtaatcat ctctaaaaat ttcaaccaac atatttatta tgttagagag   1156740
cacaaagaat aatgttactc ctccgaatac tatcggaaac ataaaaattg gtttaggatc   1156800
tggaagtccg acaaatactt gcgaattatt ctcaacatta attaccccat taacagccaa   1156860
tcccataact aaactcgaaa caaaaattac tggtgaaacg cctaaccatt gtttcttatt   1156920
atgtaaaaat tgatagtaaa ctaatctgag catctctatt cctccgtagt tgattgtacc   1156980
tctaagattt tatacaactc ttccccgcta ggtctatgaa gttctttgaa aatttttcca   1157040
tctttcaata ttaatgcacg atcagttttc gaggccaatt ctatatcgtg cgttaccata   1157100
attacacact tacccgcccc tactaactct ctcaataatt caaaaattac ttcacgagaa   1157160
acgctgtcta aagccccagt tggctcatca gcaaatatta tatcactatc agcaataacc   1157220
gctctagcta tagcaacctt ctgttgttct ccaccagaca gagttccaac aaaatcgttt   1157280
aagccagcat taaacttcat tcttttgagt aagttttcta catttttaat agttaatttt   1157340
ttttgtgata atcgcaaagg aagtgctata ttttctatta ccggcaggga aggtattaaa   1157400
ttgtatgctt gaaatataaa agatacttcg ttacgtctta tacttgacaa ttttgcattt   1157460
ctgattttat aggggttgat tccatttaaa attacttccc cacttgttgg ttcaagcaaa   1157520
ctagaaatac attttaataa agttgacttt ccagaaccac taattcctag aatacttata   1157580
aattctcctc tcgaagcaga aagagaaaca tttttcagca cttgcaacgt tttattattt   1157640
cctagtaaaa attgatgata cagccctttc acttttaata tataatcttt atccatattc   1157700
ttgcctccaa tcacttaatt ttgaaaagtg ttccattttc caatttatat atatcagtgt   1157760
atctcttgtc atttaagtca taatgatgtg aaacttcaat aaatgaaata cctaaattga   1157820
acagaatatc atgtatggaa tttgaattat cattatctaa attagctgat atttcgtcaa   1157880
ataagtacac tttattattt ctaatcagag ctctagctaa agctattttt tgtttttgac   1157940
ctccagacaa attactacca ttttcaccac attgataatt tagtatatct atcttttcta   1158000
attcttcata tagatttacc ttttttaaca cctcaattat ctgatcatct gaaaaatatt   1158060
cattttgaaa taaagttacg ttctcacgaa tagtagtgtc aaaaatatat ggtgtctgat   1158120
caactgttgg tattgaatct gaactctttt tcccatgtga taacaaattt acataacctt   1158180
tttgtggctt taaagaacca ttaattaaat ttaaaatcgt tgttttccca ctaccagaag   1158240
ttcctgttaa taatacccta aatggtgact taaatgagaa gtcaatactt aatttatttt   1158300
ctggtgtaat agaatataca acatctttca tgtgtatctc atctattgat gaagtataca   1158360
gtccgttatt atcatgttca gcgtctataa aattcttctc tccacttaag tattttaaaa   1158420
acggtttcct taaatctttg gttgtattta tcttatttaa tgaataggca attgattgta   1158480
tcggccctaa aactttatcg tttgctaaga aaatacctat cagttcacta aaagaaaggc   1158540
ttttatgata aattacaaaa taacatccta caaccaaggg aactagaaag caaaaacctg   1158600
aaattagtac tgcaaccaat tttgaaagaa cctctgatcg tttcaaatta aaagtagaat   1158660
cttctagttt atccaacttt ttatccgaca aactaattat ttctttagta acagaataag   1158720
attttaatgt cttaaaacca ttaaaaattt cttttattat gtgagtatac tctgcattgc   1158780
tgttagagta ctcattagct gaattagaca acatcttctt cataaagaca ggtactataa   1158840
tcggcaatgc tgataataca ataaatatta ttgaaactag gaagtttaaa taaagcataa   1158900
aacttagaga gacgatgaac aacaatattg aagaaattat ttcaaaaatt tgtctaaaat   1158960
agttttcttc gattaatctc aaatcatttg acaaaactga aataatagat gagtaatctt   1159020
taaccatttc agaagaaaga tactgttctc taaaatatcc ttgtttaatt tttacattta   1159080
tatctttagt tattgatgct tccgttactt ctaaatagta atttgatata tagattgctg   1159140
accaacccag aatacttata gcaccaaatc ttagaacgtc agaaaatgag gaagtctgat   1159200
ttaaactacc tgcatataca ataattcctg agagcaagac accattaaac gaagatagaa   1159260
atattaaaat ccccattaat ataagtttag tcttttttat aaattttaaa taattcataa   1159320
gttattcctt cccacttctt caaagaaata atttaaagta tcaatcatta agagaacatc   1159380
tgatggagta aaacctccat gaccagctgc tttgtttaaa tacaacaaac ttttaactcc   1159440
aatagaattt aatttctttg accactctat cacttcgtta ttattaatat atgggtcttt   1159500
ctcacccaaa atattaacta taacagtatt tgagtctcgt gccttttcaa tattttgcat   1159560
aggcgaatat gactttatat aagcctttac ttcagggtct ctaatatctc cccactctgc   1159620
tatttcggtc ttagaaagag gatcatttgg attctgaagt gtatcataag gatttataaa   1159680
tggcgaaaat aagagaatgc tttgcaataa atttttttcc tcgttcaaca ccgcaccagc   1159740
aattattcca cctgcactag aagttattaa acctaatcgc ttactgtcaa ttacatcatt   1159800
ttcccttaaa taatttactc cctcaataaa atctctgata gaattccatt tgtttaacgc   1159860
ctttcctgag cgataccatt caccacccaa atagcctcca cctcttacat gaactatagc   1159920
ataaataaaa cctgcatcta ttatagataa cataatttca tctaaatcag aattatcatt   1159980
cttaccataa gccccataga cacttagaat acattttttt cttcttggga gctcatccgt   1160040
atcttcactt ttccaaaata aagaaatcgg tatgcttaca tcataactgt cttttttagt   1160100
ccaaatcacc ttagaaaaat atttagtatt attcgatttt atgatgggtc tttcaaattc   1160160
agtttttaat gtattttcta ttaaatcaaa actaagtatt ttttcgtaaa aagttctcct   1160220
ctctaaaaac agaagaacac gatcagaaaa tgaattttca taaagtgttg tcttttcatc   1160280
aaatgttatc ttattaacac tcaactccct caaactatta tttttaaatg tagcaagata   1160340
aaagacggaa ttcgctgcgt ttgaacagtc taaaaggata taacgtccta tacagtgaac   1160400
tcttctagcc ctatcttgat atggtatagt aatagaaact ctgtctcccg aagaagtttc   1160460
ccttagaatt agttgatctt tcttttcttc agttgaagag agcccaagaa agtactgtgc   1160520
tttttctgta ctaaatagag cgatatctct aggtgttggg gctaccgttt ctgtgtaaga   1160580
gtgtctaaca aaacccgtcc ggtcgaaact gtatagaaaa atcctgcctt tctgaaagtc   1160640
tactgacttt acaaaacaat tattgctatc aatgtggact atttttaatc gaaaagagca   1160700
ttcgttttct tcaaacagtt cctcttctgt aaagctatca aaagatttat agaataactt   1160760
acttggcctc ccgtactctt tggagcgagt atacataaca ccgaatttac ccaaatagaa   1160820
cgaactttct actgaaatat cttcaatgat aaataactct tccatagtat atttttttat   1160880
tccaattaaa ttagtcgtac gcagtgagga tacaaccaaa actatataac tctcatcaga   1160940
tgaaatccta acatcctgta agatactatc atctggcaaa gtatattttt ccacatcaaa   1161000
gacaatttta agtgaatttg aattgtctaa actggaagaa ctaaccttag gaatccagtc   1161060
attatcttcg acataccatt cctttattac accagtattg ggtatactcc aattatcaaa   1161120
ttggtaccaa tatcgccctc tcctaaatat caaagaattc cattttttta attcctgaaa   1161180
tgatgaagag atagacctct tatagtgtgt tttttcctgt attgtattta aaaatatttc   1161240
attactctga ttcacaagta tgacccctta ataatggtat ctaaatatta tatttgagga   1161300
agaatcgtca atttattatc cattattgat accaatccaa ttgcaacacc cgcaaatccc   1161360
gaagcaatat ctgttgttat ctttaaacca ttatctcccg caataacaaa tccttcttca   1161420
attacacaca aatatctata aagttgttca attaatttct tttgtcctga aaagttatca   1161480
tcgatatcac tatatatatt attagcaact tcaagaccac aaaatccgtt aaataaacct   1161540
ggtaatacac aaaaaactac atcagttgcc ctctctaaag aagttaaata ttttaagtat   1161600
ttgcttgaca agatttcttt atttctatta ataagtaaaa gcaggccagc acttccagtt   1161660
gctagatatg gtagtaatct atgaccttgg ctgtactgca atgaattatt actatctact   1161720
ttataagcaa ctaattcttt atctacagcc aattctagac catttttata gatactttca   1161780
ccagttaatt tataagcttc accgaagagc caagctaccc ctgcgtgacc atatagtaat   1161840
ccaccaaaat tctcataagg atcgttactc tgaacatcac tagcgccaac tttacaaaaa   1161900
gtttctggat tttctatata atttaaagta tattctctaa gcctaattag tatttcttct   1161960
cctagtttat tatcaattcc ccctttacta agaaaataca gtccaaccag taaaattcca   1162020
gcctgcccac tatataaatt tttattttgt gaattctcaa atatctctat aaaatgagtt   1162080
gtaaaaagtt caactgcccg atctatctcc ccaaattcat aaatgagcca gattgtacca   1162140
attttaccat caaaaagacc agaaagggac gatttcttaa aattatttac tgcctcatta   1162200
ataacctgtg ttcgaatctc ataatagtca tcaaacttga aattttttac tttcttagct   1162260
agttgttgat aactccaaag gatagctaaa tctgaaaacg caattccttg attaaaattc   1162320
agaccataat aatgaactgg gaagaatctt gattgaaatt ctttacgcca ctgtccataa   1162380
gttagcgtaa accctctcaa taattttata ataaaatctt gtatatcttg ctcactctcg   1162440
atagttctaa tctcatgcat gggttttaaa acttttttcc tggaaatatt ctcaatctgt   1162500
ggacatttag aatctagata tgacaataaa ctttctacat aatctatatg ttctcttgta   1162560
taacccaaag actcaaatag tttttttcct tctatcctgg tttgacttac atagttgtat   1162620
gtcaaatccg atgtagttac tagtggcatg tataaataat gagctatttg tctaatacca   1162680
taccaatcta tctcactggg aagtgtttct cgccatgctc taaaaccagg ggctgcaact   1162740
ttatgtacaa ctttttcatc atttgaaaag acagcctgtt cccagtctat tatactaatc   1162800
tcatcttcat ccttaaccaa gatatttcct aaatgtaaat cttgatgata tacattttca   1162860
gaatgaaact tattcgttaa atcgatgagt ttttctacta tctttgaaac tctcaataga   1162920
taatctttgg tcttatcaac aacttcatat aaaggaaaat tattggtaac ccatctattt   1162980
agtggaacgc ccttcatatg ttcaattcct aagaaggtgt gctcccagat cttaccgtgc   1163040
cagtatattt taggcgtctc actccattca tttagaattt ttagtgcttt gcactccgaa   1163100
gctaatttct ctgaagaata agtaccatca aatcctagac ctgtatacgg tctagcctct   1163160
tttaaaatta tttttttccc atcttctttt agcctagcat tatatatccc accactgttt   1163220
gaaaatctaa ttgcattatc tataataaag ggaaagtctc cctgtttttt atctttcttg   1163280
tcaagccatt tattcaaaaa gtcagggggc actatacctt ttggaatttt aaatactggt   1163340
aaacgttcat ctttaacaac ttcatcgcca acaattaatt catcaatagc aaccttcttt   1163400
tcatcatccc ttgacggcct aaacacacca tacctcagat atattggtgc ttcatcccaa   1163460
cgtttatcgc ttaaaatata tggcccatta tattgcttta aggcactttc taacctttgc   1163520
aaaaccgact ctaattcatt ttgatttgga taacatgtaa taaatttacc agaaaatcct   1163580
cgactaacca atttcccgtt tcgcatgata aatttgtctt ctgtactaag atgtttaaat   1163640
ggaattcgca tttcatggca aatttttgct acatcttgta acaattcatg tgaactgtta   1163700
tactctgaac taatgtgtat tttccaccct tgtctttcaa caaattttcc aatagggtat   1163760
tgataaaccc actcatcatt attcattact tcgtgccaat taaaaggcag acttacttgg   1163820
tactttatgc tagtatctgt actataatca ttattagtga aaaagaaagg atgctccaaa   1163880
ttgaaattat aatccataac aaaatctcca agaaatttta tcaaacttaa tatatctata   1163940
gctagacaga cttatttaaa taaaaaggga gaatcctttg gattctcccc atataagcac   1164000
taacattcca acgtgcacat attggaacga catccataac tccagagaat ctctaaagtt   1164060
tacaatttaa atgaattaac aattttccca actaaaagca ctccagttac cgcaacgatt   1164120
tgtactgaat gtactaaatc gcattccatc aacttcatct gtttcgtcaa cttgaacaga   1164180
tactaattga agatttaata cttcttctgc catagctagc tcctcctatt taaatttttg   1164240
ggattaagta ctttatccac cctcattata ctctctccac cagtaaaatg caagcaatta   1164300
tacaatgttg tcacatagaa aataatgttt ccgtaacttt tcaaagtaac ttccatctct   1164360
ctcccaaaac tggaagttag ttttagaagt tacctaaaaa tcaggtcacc tattttaaaa   1164420
aagcagcaaa ctataaacta gtaggttcca caccaaatgt agtcccatac tgccccataa   1164480
gtcagattta tagcgcacca tacctaaaaa catcccaagt gaaacataca aacaccaagc   1164540
tagaatggtt cctgtatgat gtgctaaggc aaataaaaca cttgtcaaag caactctgat   1164600
atctaatttt ctgaccaaat tccataaaat ttctcgatac agaaattctt caaccatact   1164660
cgcattgatt aagaacaata aaaatgaaaa ccaaggaatt tgatgttgaa ggccaattaa   1164720
gtttgcttga ttcgtgcttc cttgagcatg aatcagacta aaacatagac ttataatcag   1164780
taggctaaca aattcaacac caagccattt catcctagat ttcatattga ccttatgcgc   1164840
ttgtttgcgt tggccataca tccataaaaa agaaatgagt gacgaaccat agagaatctg   1164900
tagtatagtt aactcaccga tacaaagaaa tttcaataag tatagagata ccaataggac   1164960
atttacttgt tggaatatat aaactggaat tattcttttc atagttacct ccgaaataaa   1165020
tcttcataat ctaaatctaa tacctgcaca atcctttcta cccatggact ttgaggcatt   1165080
cattgttcca tcttctagtg gcgaatcttt tgatacaaac gattcaattc acttggatag   1165140
tgaaactctc ccgcaaacat ttttctggtt aactcaatcc agctgatatt tctttcagcc   1165200
aaaataatgg acaagttctc ccaaaatcgt tcagccatat tgcttctcct ttagttagat   1165260
aaataatgtg tttgcgccat gtaaatcaat tgtttcgtat ctcttggcaa tagagctcta   1165320
gcctcttcca aattcagact tggataaact cgcttatttg aaaccgcaag aggaagtctg   1165380
atggttagtt caggattttt taaaattatc tcaacgaaat ccgttaatct tagattgtca   1165440
cggttcttaa atcgtaataa attgggagat aaaaactcaa aacaatctga agaatagctc   1165500
atcatctcaa ttaatttgtc ctttgtcatt tcagaaactg aatgacaaga tacctctatg   1165560
ccatagtttt ggaagaaatc taaaagaagt tgatttcttt gtctattttt acttagatag   1165620
agatcaatca tgggagacct cccaaagatt cggttccatt tgatattctg acacgattaa   1165680
ggaatctaat aaattaagga atctaataaa tttgcgaagt taatcggttt cttgtcttca   1165740
tcataagctt ttacagttac ttgggttgta agtattccct cttttccctc ggctcgatag   1165800
ccttgtccat ataaaacaaa aacgagattt tgatgatcat ctacaaaggc atcaacccca   1165860
ttctttatgt cttgactttc aaggaattcc ataacgtttt gaagatagga ttcgtaaaat   1165920
agtgggtagt tatgtttttt atggtaatca tctaaaaatg tcacttcaaa ctcacatgga   1165980
gagtaatttt gactttgaac agcctaaaag tgccatcaaa tttgaattgg aataaatcaa   1166040
ataaatagcc ccatcctcat caatccaacc tttgctcaaa gacaactcca accgatcttt   1166100
taaaactgag taaaccacct taacctccag tttcatattc ttataccgtt cactctcaaa   1166160
taaaagtttg gggagcttat aataacgctc tgatgtctga tattgattag cggtaatacg   1166220
cttcattatt gtccctccaa gactaaaatt ccaacatttc caaattcatc aaatcggatt   1166280
aaacctactt gttccatttc atcaactaac tgagttgctt ttacccaaat cattcatacc   1166340
tctctcaact agatgtaact tacaaaaccc ctgacctcat gagccacttt cttcctcctc   1166400
atgaggtcag ttttactttc tgctgttcca gtatcgtttt tcctcgctag atttcctcaa   1166460
aagggcagac tcctcccttg gtgcgtcaca cgattttttc atctcgactg ttctttaatg   1166520
catcattaac gacgcttttc ttctaggtgg ttcataagga acaggaagat tcaggttgac   1166580
ttttctaatc ctagaataaa gtgctgaaaa caattcggaa taggcataga gactagacaa   1166640
tttgaggagc tgcttgcgtc ctgttcgaac acattttccc accacgtgaa gaaaaagatg   1166700
gcggaagcgt ttgattgtta aagtttggaa gtcacctcca gctagatgtt tgagaaaaag   1166760
atagagattg taggcgatac agctcatcat catacgaact tcgtttttga ttaaggttga   1166820
actatccgtt ttatcgccaa aaaatccctc cttcatctcc ttgatgaaat tctcggcttg   1166880
accacgtcca cgataaagct gaaactggtc ttggcttgtt ccactcgtca tatttgtaac   1166940
gagagaaata acatcgtaga acaagtttcc ttcttttcgt tcagagaact ggcagacacg   1167000
acgcttgtgc gaccaagatc ctgcttgata gagagtttct gagtaggcgg agtggggcaa   1167060
gatggttaag tcctcatcct gtgggcaagg gagggaaagg tctccaagac ggctcagaac   1167120
agtatttttc ttgagtttta tgaggtagta ttgccctgtt ttttcaatta aatcgtataa   1167180
ttttggggtc gcaaagccac tatccattcg aaagagaagt tgattaaacc gttctaaaac   1167240
aggtgtgata aagctgtctg cctcttcaga acaataacga ttaccaggac gaagctgggc   1167300
attgaaacaa taacctgtct tcccctcgaa agcataaaga ggatgatagc catgagcacg   1167360
atagtgggcg ttataagcaa caccttcttg cttgccataa gttgtgaaat gggtagaatc   1167420
gatatctaca atgagttggt ttagctggtg aaactgtaaa aagaattcga ccaattcaag   1167480
gttgaggcat cgcaaactat ggactgtttc ctcgtcagtt ctggaaagaa aacgggataa   1167540
ggttggctgt gaagcaagct gccctccttc caacaatttt ggaaagtagg catcagctga   1167600
caattcttta caagcatagt ccgttccata acctgttaac agttgaaaga ggaactggac   1167660
aaggatatct gaatccgaat aacgacagta gcggcgttgg tcattcgtta ctaaatactt   1167720
agaaatccgc tcttttagtt tcaactggga aaaaagttcc tgaaaaaaga taagaccacc   1167780
atactgggtt aaatgacctc catcgaaaga tagttggtaa aaagacttgt tttggaagtg   1167840
atgatttggt aaactgttca tgtgagtttc ctttcttttt gtgttttttt ctacacttat   1167900
accataaagg ggaaactctt ttttgtctag taaaaaacac ccattgggtg aaaaaagaaa   1167960
ccatccagga tctaagctaa ggcaaggatt ctggatggtt tttagatttg gggtgaataa   1168020
ttggggtttt acaatatcaa ctcccatgat agtcatgaga tgactcttca cgaattgacg   1168080
tgatgactgt ccttcctttt gcataattac ctccgaaaca caaaaaaagg ggtagacaat   1168140
ctagtgtcta cccccgaaag tttattaaaa caaaaatcct gccaaagaat ttttggcagg   1168200
aaaccaaatc aatttatcag tttctatcaa tcgcttatcg ctctcaaaga ctggtaaata   1168260
gggattccgc aatcaaattg cgatactcta ttatttaaga gtaactgaag ctccagcttc   1168320
ttccaattta gctttgattt cttcagcttc tgcagttgca acgccttctt taacaagtgc   1168380
tggtgcaccg tcaacaagtt ctttagcttc tttaagacca agaccagtga tttcacgtac   1168440
aactttgata acgccaactt ttttgtcgcc tgcagatgtc aattcaacgt cgaatgaatc   1168500
tttagcagca ccagcatcag ctgcatcagc tgcagcaaca gctacaggag cagctgcagt   1168560
tacaccaaat tcttcttcga tagcttttac aaggtcgttc aattcaagga ttgaagcttc   1168620
tttaatttca gcaataatgt tttcaatgtt caatgccatt gttatttcct ccaaataagt   1168680
tttaaatttt ataatagttt ttttcgtagc taggctacgc tgtgtagctt aagattaagc   1168740
cgcgtcttct ttgctttctg caaccgcttt gactgcaaga gcaacgttgc gcactggcgc   1168800
ttgaagtaca gaaaggagca tagaaagaag tccttcgcgg tttggaagag ttgcaagtgc   1168860
aagaatctct tctttagatg cgacagcgcc ttcgattgca ccacctttaa tttcaagtgc   1168920
ttcagcgttt ttagaaaagt cgttcaagat tttcgctggt gcgataacat cttcattaga   1168980
aaatgctact gcagatggtc caacaaatac agatgcaaga tcttcaagac cagctttttc   1169040
agctgcacga cgcaagattg agtttttaat aactttatac tcaacttcgc ttccacgaag   1169100
ctcacgacga agaactgtat cttgctcaac tgtcaaacca cgagcgtcta caacgacgat   1169160
agatgcagca gctttcattt tttcagctac tacgtcaact agttccgctt ttttagcaat   1169220
aattgcttca ctcattagtg tgttcacctc cgtaattatt ttgcttgggg aatttttcaa   1169280
aaagaaaaac gcgcccaaac ctagacacga aagtacaata cgcttctttt tacatgatac   1169340
gttttgtcct cggtaggata tttatgagtc gagctcccct actgtcttag gcagtttttt   1169400
taaaccgtat ataagtatag catagtcaaa aaaagaatgc aagatttttg caaacttttt   1169460
taaaattttt cgtaattttt cttttaaagt tctactgtca ggacttgacc ttgcttaaca   1169520
acctgttctc cggcgatata aacatcatct acatcactag atttaactgc ataaaccagg   1169580
tgagacagca tattttcctg aggttggaga tgaattttcc cttgtggttg aatgaccaga   1169640
aaatctgctt gcttgccgac ttccagactt cctatctgat tttccattcc aaggacctta   1169700
gccccttcga ttgtcagtac cttgagagct gtttcgattg gaaactggct ggcatcccca   1169760
cttttcatct tctgaagaag agctgcagtc cttccttcct caaacatatc tagattgtta   1169820
ttggaagcaa ccgagtcagt cgcaattccg actgctactc ccgctttttg gagctggata   1169880
attggagcaa ttcctgatgc cagtttgagg ttactgatag gattgtgggc gatagcactt   1169940
gagaagatgc caagcgttca atttctctct cgtttaattc gaccccgtga gcaaatacgg   1170000
acggatgatc taaataaccc agttcttcaa gaaaagcaag ggggcgtttg ccgtatcgtt   1170060
tgaggataat tcctgactcc tccttggtct ccgccacatg gacatggagc ggaatattta   1170120
gctcttttgc catttccaaa ctcgcttcca gcaagtctct actgcagcta tacggagaat   1170180
gaggtgctac cataaccttg aaatttggat ttttatattt taagatttcg tctatgatgg   1170240
atcgagttct acttatagtc tcagcagttg tttctgtctc tgaagaaaag agagtcggag   1170300
aaaaataaca acgcatcttg gaagttttca ccacctgata aatttgctgg atatccacac   1170360
cattgggatt atacatatcg ttaaaggttg ttgttcctga ctggagcatc tctgtcaggg   1170420
cttctttgac cgcattggta gtcatgtcgg gagtaaactc agattctgct ggccaaatat   1170480
agtcattgag ccattcatgg agattgctgt catctcggat ccctctcaga cctgtcattg   1170540
cagaatgggt gtgacaattg accaaaccag gcataatcca agctccctga tagtctataa   1170600
tctgctcagc ttgctctaaa aacgctggct tatcttgacc gacatagacg atttgagaat   1170660
ccttgactgc taagattcca tcaagataaa catggaaatc ttgatcacaa gtcacgatat   1170720
ttacatgctg aaagactttc attataggct ccttttctaa aagacaagtt gtactctctt   1170780
caaaccactt cagattcact ttgccgtagg tgtggttact gacttcgtca gttctatctg   1170840
caacctcaaa acagtgtttt gagctgactt cgtcagttct atctgcaacc tcaaaacagt   1170900
gttttgagct gacttcgtca gttctatctg caacctcaaa acagtgtttt gaactgactt   1170960
cgtcagtctt atctacaacc tcaaagctgt gctttgagca acctacggct agcttcctag   1171020
tttgctcttt gattttcatt gagtattaca gtgaacaatt tttctagcta ttgtaacaaa   1171080
aaagtcactc gaaggcaact tttttcgtcc ataaactttc aaaagagaat ggcttattca   1171140
gaactaaaag ccgcagcttt ttgcatttgg taatacttac cctttctatc catgagttct   1171200
tgatggttac catattcaac aatatcacca tctactaaga caagaattaa atccgcatcc   1171260
tgaatggttg acaaacggtg agcaatgatg aaacttgtgc ggcccttcat gagttttgca   1171320
aaggcatcct gtaccagcac ttctgtccgt gtatcaatgg aagaagttgc ctcgtctaag   1171380
ataagaatct ttggaatagc cagaaagact cgggctatgg tcaagagctg agcttggccg   1171440
acagagagag attctccagc attttccaac ttggtatcgt atccctgtgg caactgttgg   1171500
atgaaaaagt ctgcattagc tgctttggca gcagcaatta cttgctctcg actggcttca   1171560
ggattgccaa aggcaatatt atcatgaatg gtcccttgtg tgagccaggt ttcttgaagc   1171620
accataccaa actgctgtct caatgatact cgtgtataat cataaatgga ttgcccatcc   1171680
agcaagatat ctcccgagct aatgggataa aaacgcataa ggagattgat aagagttgat   1171740
tttccagcac ctgtcggacc aacgatggct accttactac cagctggaat atcgatagac   1171800
aagtccttaa tcaaaatttt ttcaggatgg tagccaaaag agacatgttt aaaggaaata   1171860
gctcccttaa cttggtcact ggtcgtcaag acttccttac ctgtttcagc cacttcaggg   1171920
ctatctaaga ctccatagat acgctctacg caagccagag cactttgcaa ctcagctagc   1171980
actgaagaaa tatcgttaaa gggcttggtg tattgctgaa catagttcaa aaaagtcact   1172040
aaacgaccga cggtcaaggc tgaacccatc atgatacgat aagctcctac tccagctaaa   1172100
agggcataaa tgagtgcatt tacaaagcga gtcgaaggat tgaccgttga agaataaaag   1172160
atggctgact gagaatagcc tgagtagttg tcatgagcct cacgcaatct ttggataaat   1172220
tctgtttgag cattgaagga ctggattata gtctgctgac taagcgattc ttcaatcaac   1172280
tgagtctgaa ttcccctcgt ctctgtttgc ttctggaaga gatgatagga tttcttggca   1172340
ataaagcgtg aaatcaccat ggacagtggc gtcaacagca agactaagag agtcatgagg   1172400
agatgaattt ggagcatggc tagaatactg accaaaatca tcaaaacacc aatgaaaaat   1172460
tggttaaaaa tcatggtcaa gccagctgcc aactgttcga tgtccgtggt tacacgacta   1172520
accatctctc cactaccttg cctatctaca aaggcaatcg gtaaacgatg gagcttatgg   1172580
atgattcgct cccgtaaatc tctggtataa gagaagatta gacgattata gaggagagga   1172640
ttggcccatt gtaccagagt atttcctatt accaccaaga gcatctggag aaaaatctgc   1172700
caaaaaactg gtgatgaacc agccactagg acttggtcaa tgacctgccc aatcagaata   1172760
ggtaggtaaa ttgataagcc aacttgggca atagttccta gaaaggctag gaaaaggagg   1172820
aaaggatggc ttgctaaatc tacggctaaa cgtttgagcg tctggtttac agtttgtcgt   1172880
ttcattctag tcctcctttc catgttggga tgcattgatt tcacaataga cttggctgga   1172940
tttcatcaag tcatcgtgct tgccaacagc tagcaactca cctttttcca agaggagaat   1173000
ctggtccgcc atctgtaaag ttgaggttcg ttgagagatc aaaattaagc tcgtgtttgg   1173060
aaaattttct ctaatagctt tcaagagctt ggactctgta atggtatcca gtgccgaggt   1173120
tgcatcatct aggatgagaa acggagcctg gcgcaagact gctcgggcga tagacaatct   1173180
ttgtttttgt ccacctgaga aatttcgccc ccctgcctca actagagcat ccaagagtcc   1173240
ttccttttca ctgacaaaat ccttagcttg cgcaatctcc aaggcctgcc agagttcctg   1173300
gtcagatact tcttgattga aacctagagt caagttggaa cgaatggttc ctttaaagag   1173360
ttcgaccttt tgaggtacat aggcaatcca agaccgccac tgctccaaat taagaggact   1173420
acgtccattt tgataaaggt caatgttccc cttgtctact ggataaagtc caagtaagag   1173480
ttgcaccaag cttgatttac cagaaccagt tcccccgatg atacctagaa tttgtccttg   1173540
agtcatatca aaggaaatgt atctcagaga aggctgggcc gcatcaggat aggtaaaggt   1173600
caattcttgg acttgtaaaa ccttatctct ggtagcttgc ttttgttcta actctgaatg   1173660
gatatcctct ggagcctcaa caaagacttc ctcgattcgc ttgactgaga tataggactg   1173720
gttgagggaa ttgatcaaca tggctagctt gaccaattcc accaaaatct gtaagaggta   1173780
attgataaga gcaatgagag caccttgact gagcactcct ccttgaattg aaatatagcc   1173840
ttgccagata ataacgagaa gagttccatt gacaatcaga taggtcagag gtgttaataa   1173900
actagaccag aaacctgtct tttcttgtaa tctagcataa acttggttaa gggtttgaaa   1173960
aatctgtaac tctcgttttt cttgaccaaa agcacgaata acccgcatcc cttgcaattg   1174020
ctggcgcgtt tcctgaacca gttggtccgt tttctttctg agactactgt agaaaggatt   1174080
gaccaatcga gataacccta caatgacaat ggtcaaaatg gcaaccaaga ctaagaacca   1174140
gaaagtcaac tcagctgaga ttcgataagc cataaaaatg gcaccaaaaa cgataatggg   1174200
cgctcgtaaa aagagacgca ggaattgatt gataccagtc tgaatctggt aggtatccga   1174260
agtcaagcga gtgaccaaac tagaagttgt cagacggtct ctgctgtcct tgggcaagga   1174320
aagaatatga cgataaagat cgtttgtcaa ttccttagca gaacctactg ctgcctttgc   1174380
tgagtaaaat tgagctatca aggccactaa aacgccaatt actgcaaaga taaggagcag   1174440
gccaatctgc atccagagat gaccttgatc tccctgaggt aaagattggt caacaatccc   1174500
agcaatcacc atgggaacca agagctcaaa aacagcttct aacagcttga acaagggggc   1174560
taaaattgat tccttgatgt agggtttgaa gtaagataat aggtgtttca taaatccctt   1174620
ctattcatat tctagaaatg aagaaagtgg gaagccccac tctctgtttt atttgtttaa   1174680
gtaaggcaat agatagccat atcctgcttt ttccatctca tccttggcca caaagcgtaa   1174740
agaagcagaa ttgatacagt aacggaggcc gcctaactcc cgcggtccat ctgtgaaaac   1174800
atgacccaag tgagcactgc ctgaacgaga acgaacttca attcgctcca ttccatggct   1174860
cagatccttg taataatgaa tcaactcttt ggaaatcgga cggctaaaac ttggccaacc   1174920
acaacctgaa gcaaacttat ccttggcaaa aaagagtggc tcacctgtcg taatatctac   1174980
ataaatcccc tcttcaaagg tttggtcata ggcattggta aatggagcct ctgtagcagc   1175040
ttcttgtgtg acacgataag actcttcaga tagactggcc ttcaacacct cttgactagg   1175100
cttttcatag tttgctgcat caatcaatgg cttatcagca tcggtcacat cgatatgaca   1175160
gtaacctgaa ggattcttcc tgagatagtc ttggtggtag tcttcagcca gaatgtagtg   1175220
gcgtaattgc tccacttcta ctgcaatctt tcgacccagc atgcgttcct gctcctgcac   1175280
cactgtgtag atagctggca aatctgcttc atcctgataa taaatcccag ttcgatattg   1175340
gcgaccacgg tcattccctt gttgattgat agatagagga tcgataactc ggaaataata   1175400
aagtaaaatc tctctgagtg acacttcctt ctcatcgtaa atcacttgga ccgtttctgc   1175460
atggtctgtt tccttgagca actggtaatt ggtcgtttcg acttgaccat tagcgtagcc   1175520
aacactggtt tctagcactc cagaaatgcg tgaaaaatat tcctctaggc cccaaaaaca   1175580
accacctgct agataaattt ctgccatctt tatttctcct ttatcacgtt tttaactaat   1175640
actcttcgaa aatctcttca aaccacgtca gcgtcacctt accgtagtat ggttactgac   1175700
ttcgtcagtt ctatctgcaa cctcaaaaca gtgtcttgag ctgacttcgt cagttctatc   1175760
tgcaacctca aaacactgtt ttgagcagcc tgcggctagc ttcctagttt gctctttgat   1175820
tttcattgag tataaacttc ttttcacaaa aaggatatga acccctctgg tcaagagttt   1175880
ccccatccta tcttctattc tttattttgc ttctacacgg acaccttggg tatcaactct   1175940
caagtcatgc agttttcctt tgaaaggttg cttttccaat tctgccttaa ttgttggcat   1176000
cttgtcatga gaagccagaa ccataactgt cggcccagca ccagaaaggt aggttgcata   1176060
ggccccattt tctttggtca cttgcttaat catcgcaaat tctcttacca agtcctgacg   1176120
atagcgctca tggaagaggt ctccctcgat tgcttgccca gcggtcacca tgtctcctgc   1176180
caacaaggca gcaaccgcta cattggcgat agaacttgca gcaacagctt ccttataaga   1176240
caatttttta ggcaagacac tacggctgtc gcgagtacgt aattcatagt ttggaatgta   1176300
agctagaaaa tcacactctg gaaagtctgc tacgatagca gagacttgcc cttcaacaga   1176360
acttgcaata acgagattac cataaatggc tggagccaca ttgtcaggat gcccttcaat   1176420
cttggtcgct aactgcaatt tttcatggtc tgataagttg agttgaccca gttggttggc   1176480
tagttcaatc ccagcaacga taaccgagct ggaagaaccc aaaccgcgcg ccaaagggac   1176540
atcactggtc attttcaagc gtcttggttg caagtctggt acaatttgca aagcgatttt   1176600
gagcaagaga ttacgctcgt catgtggaat ccatttgcca atctggtgtt caatcagcca   1176660
ctcatctcgt tcttcgcaga cctcaatttg aagatacttg gttacagcta caccgaccga   1176720
gtcaaaacct ggcccgatat tggcactggt tgcaggtaca ataatcttca tcttattctc   1176780
ctagcacctt gaaggtattc aagaggtcga attctgaaac cttcttcaat tcagctgaga   1176840
cattttcaag ctgggcttta ttaatcttgt gtgtgatgat aacgacacgc gccttgtcac   1176900
cctctttgcc atcttgaagg atttgcttaa aggaaatatc ttgagcattg aagatttcag   1176960
ccaacttcaa gacctgacct tttgagtcta gagccaagat tgagaaatag tagtttgctt   1177020
tgacatcttc aggatttgcc aagaccaagt cacggctata ttcgttgaag tctttgccaa   1177080
tagtaccatc attcaaacga cgaacgatac ggacaatatc agctacaaca cttgttgcag   1177140
ttggtttttg acccgcacct ggtccgtagt acatagactc accaataccg atagattcta   1177200
caaagacagc gttcattacg ccattcacac tagcaagtgg gtgcgcttta ggtaggaagg   1177260
ttggagtcac ttctgcagca atacctgaag aagtttcctc aatagaacca accaatttca   1177320
ctacgtaacc aagctcttga gctacagcta cgtcttctgg tgtgatattg cggattccct   1177380
tgtgggctac atcatcaaag gcaatcttca tgccaaaggc aaattggctc aaaataacca   1177440
tcttgtaggc tgcatcaatc ccatctacgt cattcgtcgg atcgctttct gcaaatccta   1177500
gacgttgtgc ttccgcaaga gcatcatcgt aagaccagcc ttcttccacc atcttggtca   1177560
ccatgaagtt ggaagttccg ttgactactc caagcacgcg cgtaatttta tcagaagcca   1177620
aggaatttgc taaagtacga agaattggaa tcccaccagc aactgctgct tcgtagtaaa   1177680
gtgctacctt gttagcttga gcgatttcta gcaattctgc gccatggaca gctaaaaggt   1177740
ccttgttagc agtaacaacg tgttttccag cttccaaggc acgagtgata aaggttttag   1177800
caggctcaat acgccccatc aattccacta cgatagtaat atcctggtct gataaaatat   1177860
catccacatt ggttacaaag ttaaagtcat tccctgctgc aagcaagcga tttttttcat   1177920
cttcatcctt gaccaatacc ttagcaactt tgatatctga atgtgctgat tgattgattt   1177980
ttcctccatt ttcctttagg aggaaaggca caccacttgc aacggtacca aatcctagta   1178040
aagcaatttt aactgtcatc tttatctcct cgaaattttc taatatagcc attataacag   1178100
aattttgtga aaattcctat tatagtaaat cactatttca gtataaaaag aaaaaacgaa   1178160
tcagacgatt cgctcttctt aaaatctgaa aatagctttc cagaaaggat tagccgattt   1178220
tttgcagatt gagcactgca tcgtgactca tcaagacttg accatactct tgtaagactg   1178280
agcgactgat atcactatcg tctgcaaact cgcgcatacg ggccaacagc caagctggat   1178340
atgggcttgg atgattttca atatccacta aaatggtcaa ataatagcgc tcgttcattt   1178400
tgtagagttc agaagtttcc atttcaaaag tcactgtctt ggcaaaagct accaagtcag   1178460
ccaacttagc aaaagaaagg atgtagtaga tgtaaggttc tttcttactc tcagcttctt   1178520
gttcagcctg ctcttgctct tcttccttga cttcaacttg ctcaagagat tgaatggctt   1178580
cgatatcatc cttggttttg tctgcgatgc ttttttccag ggttttgata aattcatctg   1178640
gagacatttg agccaattct tccatatctg gcaaatccga taagtcttca aaatctagat   1178700
tttggtcaat ctttgacttg gtcacaaaga catctacctt atcaggtttt ggagtcacac   1178760
ggaagctcaa catgcctgta tccagaaagc tatcaggcat ctctagctca tccaagatag   1178820
cataaaagaa ctcttctgtt ttttcttgag gaacgagaaa gtcagcaatc tccattccac   1178880
gatccatcaa atcctctaaa gatatcgtga tttttaaagt tgtatcacta atttgtttca   1178940
ttttcattgc tagtaacctc atactttcag ttctatctat tatactagat ttttacgatt   1179000
ttatcaaaag aaggctcctc tatacggata gattttccct agggtctttc tataggagac   1179060
tccaaaagaa aatttctgca gacagataga aaaagccttc aaaatcggct aagagccgac   1179120
tttgaagacc ttatacatca gaatacttat aatttaaagg ttgctacacc gaggatagaa   1179180
cgatttaagt ttctgagaat ttgaagactt tgctcaaatt tcttataacg agtcactccg   1179240
tactcttcaa caagaaggac tgtatctctt tccaaaagag atgatacatc ctgtaaatct   1179300
acaaaatgca ttccttttaa agcttcttga ctctgtttca atttatctaa gatagcttta   1179360
tttgagctaa cgatggtcaa ttcctgtcca gtatttttgt atgacaaaac atctgctagg   1179420
ttagcaattg ttgtaatctc tgttacaaaa tcaatttgat actgagaaaa atcacctact   1179480
ctattgattg ttggattaaa gagataaact aacacatttc ccatcacaac caaaatcaca   1179540
caaaccactc caataacaac taaacgaaga atcagatttt tcacatttaa gccaagcgct   1179600
gtttcaccat ttgcgttcaa ttctttagag ttgatggttt ccagtttttc aattttcaca   1179660
tttgcatagg catgtttaaa tttctcaatc aacccatcaa tttttttctc taacaagtta   1179720
ttggcatctt tacttgatgt caaaattttc acaccaaccc ctgcatcgtc aatcatatag   1179780
tagacggtca attttttcca ccaatagtca ttcgttgaat ttttcaaggt tgtttctgtc   1179840
gtgtctaatt cactggcaat ttttttcaac tcactgggtt ctacatcatt gaaaagataa   1179900
gctccattca aattaccatc aatcaatttc ccataaaaat cactataacc accaatttga   1179960
tgattcaaaa tcgttttgtc cgactctttt ggaggagtga ttttatagat aagataagtt   1180020
gaataacttg ttgtatcttt gacagtgttt ttattcctaa ctgctttaat tgtaaatggt   1180080
acagcaatga gagcaaataa agcgatgaga gctaaaatat ttgcttttcg ctttttataa   1180140
agatttgcaa acaaatcagc tactgaataa tgttcaaaca tgattttttt ctcctttgtt   1180200
tagtagatac tagttttcct ttgtaagcat ttttgctaca aatataatca caagaacaat   1180260
tccccagaat tgcattgtaa ataaattgaa gaaactttct gaaaagctgc ttcttggcat   1180320
aaagaataga ttattcaaga tgagtaggga taaagcaaat aggattgtcc ttgagcgata   1180380
ggctacttgc agcatggcta taaataatac gccgagtaag aaactaagca gaaagactcc   1180440
aatcatacca tagtcggtat acaactccat gatataacta cttccgatac catgcccttt   1180500
caagtattcc ttgttcaaga caagatagga tagattgtgg gcataactat tactatcaat   1180560
agctagttcc acactattgg ttgtatgttc aaaggctttt cctccgaaaa tggctcccaa   1180620
actccccctt gcaaaataat caagaacagg accaaaagta aaattacgga aatctcggta   1180680
agggaggcta ctgttaaata gaaaacctcg agccagaaca ccaaaactag tcccttgttt   1180740
atagataaag tcaagtaaga tatcccagaa acctgtatgg gaaacttgga cattatcccg   1180800
tacataattg agtactccca tcgctaacat gagaatagga gaacctacaa aaatcgctaa   1180860
cttttcttta aacccaatcc attttccttt ttcagtttgc tcccgcataa agtaataaac   1180920
aaaagcaaat aaaatactta aaataaaggg atttcgtgtc ccaattgcca aatgaatagt   1180980
attagctgca ataaaggaga caagcactgc tgtggcctgc aatttctttg gcttggttgc   1181040
cagatacata cacattgcat agaccgtaaa ggtagacaaa atgtaggtaa aataaggcag   1181100
tttactttca aaatttgcat agtaggcata gtaggaagtc tgcaaacgat acaagagccg   1181160
ttcaaataac cgaatgaaat agaaaggata agttagaaga aaaactccta gtgatacaaa   1181220
gcgtaaccgc ttgatataaa cctcttttag agaatttcct atatttgcta cttttatttt   1181280
cttcctagct atgaagtaac gagccagaat gcctcctgtg gtcaagccca gaatcgaaat   1181340
catgacaact ataaaggcaa aacgataggc tattggatga taggtatcca aagcaccatc   1181400
cctaaaataa tcaatggtcg gtcttgatac cagaaataca aaaatggtta aatagaaaat   1181460
aaaatggatt aagtaatact tgatatcatt ccaacaagca attaagctac taaccaacaa   1181520
gaacaataaa gtagaaagta agctaacatt attattatta aacagataca caattccact   1181580
tactagcgtc aaggcataac tgactatggt caaactaaat aataatcgtt tcccatcaat   1181640
cacttggtca cccccgttct aatgtaattt tttagatttt tcaatatttt tcagtaataa   1181700
gaatcgatat aaggaaatat ttatgaatag ggccaaagca ctaattcttc tccccttacg   1181760
gaaaattgga ttcctagaaa tagcaaaggc atggcctttt aaaaaacgat gaatctgaga   1181820
ataggcttca aactgtttat actgatcatc tagcaacatc ttatccagaa taaagaagtg   1181880
ggcataggcc aatctgaaaa aagcgacctc tttcaagtca ggatagtttt tcacaacttc   1181940
attataaaac ttttggtaga tatcaatata ggctaaatcc ttctctgcat agggtttggt   1182000
cgtaatacta tcccctctat ggaaatagta ataatagggt ttagtattaa ccacatactt   1182060
cttggccaac ttgattaaat caaaatggta ataggcatct tcgtaaatca accccttagg   1182120
aaaggatagg gcagttgcaa tctgtctctt gattagctta ttgcaaatcg tcccaggtat   1182180
tttttcacct atgaggtatt cctttagaaa tgtttgagaa tcacagacaa aatagtcatc   1182240
ctgattggct gactgtgggc tttcatcatt agcatagaca ttcatgacac cacagctcga   1182300
aacatccgca tcttcttgaa ctaattgctc atataagctc tgaatcattt ctggatggat   1182360
ataatcatct gagtcaataa aaatcagata atccccgtga gcctgcttca tcccatcatt   1182420
tcgtgcttgc gacaatcctt cgttcttttt atgaagcact gacaccctgt catcttgttc   1182480
agcgattgaa tcacacaagc gaccactttc atctgttgca ccatcatcaa caagaataat   1182540
ttccagattt tgataggtct gcttctgaat ggaagctatc gatttttcta ggtactgcgc   1182600
cacattatag actggcacaa tcacactaat taatgcagtt tccatgctac tcctctaata   1182660
gtttttctac ttgttcgatt tgttttgtaa ttgtaaattg ttgaatgaat tggctagcct   1182720
catcgacatc aaagtttgag gcagaagtca tgtaattagt aatcgcctga gctgcctctt   1182780
gattgctctc aatgatttgt ccaaatcgtc cttcttggga taattcctca gcccctccaa   1182840
cgtccgtaga gataaaaggg agtcccagac tcaaggcctc cacatacact ccaggaaaac   1182900
cttcttgttt agacatagac aaaagaactt tcgtctgaga tagatactga taaggatttt   1182960
tttgataacc aaggaaatgt acatagtcct caatcccata ctctttgact cgttttttca   1183020
gttcctcttc catatcacca gccccgataa aatagagatg atagtttttt ccctcttggt   1183080
gtaataatcg tatcacttcc actacacggt cagaaccctt attttcctca atccgtccga   1183140
tagtacagat actttgagga gcaatctcga tatcgatctt ctcttgagat ttttctagaa   1183200
tagtctgaaa atcatatcca ttgtagattg tctgtaattt agaagtataa tctggataaa   1183260
cttccttgat agaattgctg gtcttttttg aaatccctac aattgtattc gcagcatcca   1183320
actggcttct atgtgattct cttttagagc tatccttaag aagttcttca atacttccat   1183380
gaatccaaga tatcttcttg acttctcttc ttttagagaa caacagtggt ggattcataa   1183440
tggtaaaaga aacttcaaca tcataatcat cttttacaag caaacgacga gtcagtcttg   1183500
gaaaataaat tctcattctc cacaaaaaag ctcgtaacca tctggtttgg cgataatctt   1183560
gaagggattt taaaatgcgt acatgctttg gaacagattc atatcccttg tcaaagtgct   1183620
ccatttcaag aatatcaata tcatactttt ctggatccag atttgaaaca atggttgata   1183680
gaatcttctc tgcaccacct ccaagagaaa aagaccacat aaaaaataag atttttttct   1183740
tagccaccat attctccctt gtattctgta taagacttat ccatatcagc gatgacagca   1183800
tcatgatgcg gtacctgctt gtctgctggt ggaggcgtca tataatcccc aaaagcagtt   1183860
ctgagataga catcatagcc gattggaata ggcatctctg ttccttcaaa tggcaagaaa   1183920
agattgtctt caaaagatgt gattgggtac ttgtttctca tgtagccagg acctgagcat   1183980
aattctgtaa tgccatcaca atcagccaaa tcatacttag tcatttcttt ctcagctttt   1184040
ttccagatgc gataacggag agattttgga gtcaaaccca gtaaaatgcg acttccccat   1184100
ttcatgagat caccatgctt ttctggaata gtttgcgcac aaaagagtga ataaatcaag   1184160
gcccaacgaa cctgtttttt ccgctcagct ggatttttcg gataataatc caaaggcaaa   1184220
acatccaagg ccagaccatg tggcaaatcc aaatcctgct gataaggctt gatacaggtg   1184280
gttttcttgt cacgaatggt aataaaaaga ttacgatcaa caaaatcctt gtgactcttt   1184340
gacaagaaat aacgttcatc tgcataacga ggccataatt ctgctaattt ctcataatct   1184400
ttacgaggca taaaaaagtc taggtcgtcg tcccaaggaa taaatccctt gtttcgaagg   1184460
gcaccaatag cgcctccgcc acagagataa cagagcaaat catgttcttt acaaaaggcc   1184520
acaaaatatt cagccatctc cagactacga gcctgaattg cttttaaatc agtcatattg   1184580
ttcattattc tttctatcgt atcgtttcat tataccacaa acaaggggtg aaaatctatt   1184640
gcagactgta aaaaatcaaa gcctgactgc tatccaaata gctatcaaac tttgattttt   1184700
ctgtcttata ctcttcgaaa atctcttcaa accacgtcag cttcaccttg ccgtaggtat   1184760
aggtaactga cttcgtcagt cttatctaca acctcaaaac tgtgttttta gcagcctgcg   1184820
gctagcttcc tagtttgcac tttgattttc attgagtatt atcttatctt aagcccattt   1184880
gagcgagctt ggtttgatat ttgttttgat caaccagcag gcccaagccc ccataaacat   1184940
cataggcatc tacccagtca cccagttctg gaatcgtcaa tttttcaata ccattttttg   1185000
ctccatccaa aacagataaa ccgtttgtta ggaggaaagt atagggtacg ttggttgagg   1185060
tcatagcaaa aacctttcca agagcttcag aaccagtgaa aagtttagtg ggatctttaa   1185120
tttgctctaa aattgctgtt aaaacttgtt gctgtctttt tgtacggccg taatctgcct   1185180
catcatcatc acggaaacga gcataattga gcagggtcga gccattcatc tgctgttttc   1185240
cgactttaat ggtttgggtt ggagactcag tctcggtagc gtataaatca tctccgactg   1185300
tagcttctgt taggggacgc ccattcaatg ttgaaaattg agcatcaatc gtcaccccat   1185360
cagggaaaag cgtgtcaatc gctgtggcaa aggcctggaa atcaaccaag gcgtagtact   1185420
taatgtccaa gtcaaaatta tctttcaaga cttggcgaac catttctgcc cctttttgcc   1185480
cctcttgttc tcctaactcg taggctacgt ttaacttgtt atctgtctgt tttctaccat   1185540
taatcacttg actataacca tctatataga ccaaattatc acgcatgaaa ctgactagct   1185600
tcattttctt atctgagccc ccgacattta ataccataat agagtcagtt cgtgtctcaa   1185660
cactgttctg gccgattcga ccatcagtac ccatgattaa aatattaact ccatctctag   1185720
tgtcctgacc attaaagact tctacttgag ctgcccgggc atcagcagtt ttctttgcgc   1185780
tagcatcttg gtaaccacgc aaaaacatga ataccatggc caaagccaca cagaccaaaa   1185840
gtgaaaaaat caccataaaa attcgtttaa gacggagctt ccgtcttttc ttttttggag   1185900
ggaaagagag tgcttgtgat ttggattgtg agcgactccg gttcgcatag cttggtaagt   1185960
caacctgctc ttctctttct tgttccaagc tagagctact atttccccta gcaagagtta   1186020
gcttttcttg caaataggca aactcatttt tttctctctc attgagatag tgaatatttt   1186080
ttagcaaata atcataacgc aactgctcat gatgacttaa gggattttct ttactcatct   1186140
tctctccttt ccatggtctg atattggata aataggatag gcacccagaa ttttatactg   1186200
gattccaatc gcttctaatt ctttttgggc aaagtggacc aagtccttat cggtataatc   1186260
cacatcgata atgaaaaagt attcacccag tgctgtcttg agtggacaac tttcaatttt   1186320
tgtcaagtca attcctcgcc aagcaaaggt cgacagggcc ttataaagtg cacctggaag   1186380
gttgtcaggt aatgtcaagg ccaaactcat cttttcagtt tgtgcttgca agggaatact   1186440
aggcttttca gctcctagaa cccagaaacg tgtgaaattg gcttccattt cctgaatatc   1186500
ctcggcaatc agttccaatc catattcttc agcagaactt ctaggtgcaa ctgctgcaaa   1186560
gggctggtct ggatgttcgg aaataaaacg ggccgcataa gctgtactag ctgttacctc   1186620
gatttgagcc tctggatatt gttcatcgat gaatttcttt ccttgagcca aggcctgtgg   1186680
atgtgaaaaa atcttttcaa tcttagtatg gcctggaacc accatcaact gctgatgaat   1186740
aggctgaacg atttctgcta ctgcttggat gtgagcctga tgaaaaagat agtccaaggt   1186800
ttcatgaaca ctaccctcaa tagaattttc aactggcacc acagaatagt tcactaatcc   1186860
ttgctcataa gccttgatga catctgtaat gttggcaaaa gcctgcaatt cctcatgagg   1186920
aaaagctgtc tgcacaacgt ggtgtgaaaa tgatcccttg ggacctagat aagcaatttt   1186980
catcttagtt cctctataat ttcctctggg cttagcttgg tcacatccaa aacccgacta   1187040
gccacttcct cataccaagc ctgtctttct tggaaaatag ctactagttc ttccttgcta   1187100
ttatttagaa aaagcggtcg ctgattgtcc ttatcagctg cgatacgttg gtagagggtt   1187160
tcaaaatctg ctctcaggta gatgttatct gtattagtct tgagtaagtc acgatttctc   1187220
tgagaaataa ccactcctcc tccagttgac acgacttggt ctgtttgtag taaatcagct   1187280
aggacttctg attctacctg acgaaaggct gtttctccct tttcagcgaa aaaattcgca   1187340
atggacatac ctaggcgatt ctcaatcaga gcatccatat caaggtaatt agggtccaag   1187400
cctcttgcaa tagtcgattt tccagccccc ataaacccta ataacacctt agccatgaat   1187460
caagctctcc aaatcatcaa agaaactagg atagctggta ttgatggctt ctgcacggtc   1187520
aagctccacc tctccatctg caaccaagag ggctgcgata gctgtcatca tgccgatacg   1187580
gtggtcacca aacgtattga ctctagcacc gtgaagagct gattttcctt tgataatcat   1187640
cccatctgcc gtaggagtaa tatctgctcc catactattt aaggcgtctg ccacaacctg   1187700
aatacggtct gtttccttga ccttgagctc ctcagcatcc ttgataactg ttacaccttg   1187760
ggcttgggtc gcaagcaggg caataatggg caattcatca atcaatcgtg gaatcaaagc   1187820
gccaccaatc tctgttcctt tcaagtcaga agactcaaca atcaaggtag cagatttagc   1187880
gactggatcg atttcagtta tttccaattt tccacccatg gcacgaatga catcaataat   1187940
accggtgcga gtttcgttga tccccacatt ctgcagcact agacgagaat ttggagcaat   1188000
caaacctgcg actaaccaaa aggctgcact ggaaatatct cctggtacga ccaccttctg   1188060
tcctgtcaat ttttgtggcc cctggactgt gattttctta ccatccacac ttaaatgacc   1188120
accaaattgt ttcaacatat cttcagtatg attacgggtg tactcttttt cgataataac   1188180
tgactccccc ttagcttgta aggctgcaaa catcaaggct gacttgactt gggcagaggc   1188240
aattggcaac tcataatgaa taggtcttag gtttttcgtc ccttttaagc gaaggggagg   1188300
caagtctcgt tcagtttgcc ctgaaatgct gacgcccatt tttttcagtg gaagggtcac   1188360
acggtccata ggacgtttgg aaagactatc atctccaaac atctctactt cgaaatctgc   1188420
accagcaagg acacctgaaa tcaggcgaat cgaggtgcca gaatttccca tattaagggc   1188480
attttgtggc gcttttaagc cagccatgcc tacaccttga atggtaataa ccccatcttt   1188540
atcctcaatt tcaacaccaa ggtcacgaaa aacctgcatg gtcgaaagaa cgtcttcacc   1188600
tcgcagaata tcataaacct tggtctcacc ctcagccaaa cttccaaaga taatggaacg   1188660
gtggctgata gacttgtcac ctgggacgcg gatactacca tgtaaatggc gaatgtttgt   1188720
ttttagtttc atactggacc tcatacttgc aatactttta cctattttat cataaaaagc   1188780
cagaaattcc ttaaaaattc ctgactttag gatcgttctt ttcttatttc agcaattctg   1188840
aaactggttc aaaaacaatt ttttcaatat cagaaaggta aatggccaat tgttgttgct   1188900
tggtaaagaa ttctgacaag aggctatttc cttgaatctg tttaccaaag ccttccatct   1188960
tagcttggaa ggacgcatct ggcatttgac ctgtctgtgc tagtttttga atttcctctt   1189020
gaaaggcaag ataatctgta aagattttgc ttgcctcagc atctgctgca atcgcatctt   1189080
tagctgcttt aacagccttg tattctggta atccgcgtag accgcgactg agttcgtttg   1189140
cactatcgta aatatttgac atgttcttct ccttatttga tgacgactgt atagtcagta   1189200
ttttctgtta tgagatgctc agctctttcc aagtcttgag catttttaaa tgaaatttgt   1189260
aggattccgt gaatatcctc acgattttcc tcgttgatgt ggatattaac caaggaagtt   1189320
ccacgtagca gttccaaaat ccgcaggatg acatcttctt catcaggaac gtcaacatag   1189380
aggtcgtaag agctatccac accaccacgc ttatggattt ccatggtctg gcgttgttca   1189440
cgcgcttggt taaaaaagtt ccaaatttgc tcttcatctc ccttactaat ggcctgacca   1189500
atcgcttcca aacgttcctt gaaatcctca attctatcca gaatgatctc gctattggac   1189560
aagagaatgg aggtccacat tcctggctcg ctttccgcaa ttcgggtcat atctcgaaaa   1189620
ccacctgccg caaagcgcct tgccatctca tgctcttgag catagaccgc agtctgctcc   1189680
atgagactag aagccaaaat atgaggaaaa tggctaatct gagaagtgac acgatcatgc   1189740
tccttggcat caatctcgat aaaacgagca tgaagacctg aaagcagatc cttcatttcc   1189800
ttaagcgtgt cctgacttgt caggcttgaa ggtgtaaaga tataataggc attttcaaaa   1189860
agattgacat ctgccgaagc agcccctgtc ttgtgactac cagccatggg atgggccccg   1189920
acaaagcgaa cagacttgcc agccaaatac tgctccgccg catccacaat ggttgacttg   1189980
gtcgaaccag catctgaaat aataacgcct tctcgcaaat ccaaattggc caactcctta   1190040
atgaaagcaa tagtttgttt gattggcaag ctgaggataa tgacatctgc caaaggagca   1190100
aaactagcaa aatcatccgt tgcacggtca atcatacctt ctttcaaggc gatatctctc   1190160
gaagcttgac tacgattata acctaaaatt tcataatctg gatgatcgcg tttgatacca   1190220
agtgccatag aggctccaat caacccaaga cctgcgatat agattgtttt tgccatagga   1190280
actccttaat agttctttgt atagtctcgg tgtttggcta ccgcttcttt tagttcctca   1190340
agattatctg atgagaattt ttcgaggatt tcttgcgcca gaaccgttgc tacaactgct   1190400
tccatgacca ttcctgcagc tggaagagca gtcggatcac ttctctccac ggttgccttg   1190460
taaggttcgt gggtttcgat atccacactc ataagaggtt tataaagagt aggaatgggt   1190520
ttcatgaccc cacgaacaac gatgggttgc ccattagtca taccaccttc aaaaccacct   1190580
agattattgg tacggcgagt ataaccgtct tctttagacc agagaatttc atccataact   1190640
tggctgcctt tacgataacc agcctcaaag ccaagaccaa attccacccc tttaaaggca   1190700
ttgatagaga caacagcttg agccaatctt gcatccaatt ttctatccca ttggacatag   1190760
gaaccaagac caactggaac gcctccgacg actgtctcca caaccccacc gatggtatca   1190820
ccatcacgtt tgatttggtc aatatagtcc ttgatttcct gttctcgttc ttggttgaca   1190880
atagaaactt cagactgggc agctctttgc ttaatttcag cgactgtcag attttcagga   1190940
acatcgattt ccttgccacc aaagaccacg acatggttgg caatctccat atccagctca   1191000
gccaagaggc gtttggctac tgcaccaact gccacccgca tggtggtttc acgagctgat   1191060
gaacgctcca aagaatttcg caaatcatca aaacggtact taatcccccc aaccaaatcg   1191120
gcatgacctg ggcgaggatg agtaattttc cgcttgcttt taaggcggtc ttcaatgtcc   1191180
tccgcagaca tgatgtccag ccatttctgg tggtccttat tgatgacatc catagtaata   1191240
ggcgcccctg tcgtcttccc gtggcgaacg cccgaagtaa agacaacctg gtcattctca   1191300
atcttcatac gaccaccacg accgtagcca ccctgacggc gtctaaggtc ctcattgata   1191360
tcctcagctg tcaatggaag tccagctgga attccctcaa taatagctgt tagacggggg   1191420
ccgtgtgatt ctcctgcagt taaatatctc atacactctc cttattttac caagtagtct   1191480
ttcatctctt ccagagaaac tgggtgaatg gtcgctgaac caagctctgg caccaagacc   1191540
aatttcaagg tgttaccacg cgctttcttg tcatgagtaa gagcctgata aagcttgcca   1191600
acttcccaat tttcatagtc aacaggcaaa ccgaatttct gacacatctc tgtgatagat   1191660
tgggtaatgc cagctggcat gaggcctttt tcctcagcaa ccttggaaat ctgtaccatt   1191720
cccatggcaa cagcctctcc atgcatgacc ttgccataac cggcagtcgc ttcgatggca   1191780
tggccaatag tgtggccaaa attgaggtaa agacgaatac cattgtccaa ctcatcttca   1191840
accaccatct tgcgcttcac ctgacaagaa tgttcaatca aggtctctgc atgttccaaa   1191900
atactctcaa cagaaccatt cagtcccgtc aagagagccc acagttctgg atcctcaatc   1191960
aagccatact tgataacttc acccatccct tcaatcaact ctctttttcc gagggtttca   1192020
agaacaagtg gatcaatcag aaccccatct ggttgggcaa aggtccccac catattttta   1192080
gcaaatggtg tattaacgcc tgtctttcca ccgatagaag aatcaacctg agctgtcaaa   1192140
ctagtcggaa tctgaacaaa gtgaataccc cgcatatagg tagaggctac aaatccagcc   1192200
aggtccccaa caacgccacc accaagagca acgattccat cgctacgagt cagaccttgc   1192260
ttgactagaa attcatagac tttctgaaca gtagttaaat tctttctttc ttcaccttct   1192320
aagaaatcaa aaacagctac ctgaaaacca gcatcttcta ggctgagctt gaccttctct   1192380
gcatagagag aggctacatg gttatctgtc acaatgacta ccttttgcgg ttgccagagt   1192440
tctcgcaacc actgaccagc ctgggccata caaccttttt caatctgaat atcataagga   1192500
tggtgaggaa tatcgattct gattttcata ggagagtctc cctttcttta ttggtatttt   1192560
tctgttaaag actgccaaat ctcttctgtc ggcatttcct tgcctgtcca cagttgaaaa   1192620
gcttctgcag cttgatagag taacattccc agaccattga ctgctggatt gccctgactt   1192680
ctagcccatt tcaaaaacgg tgtttcaaag ggttggtata tgatatctgc aactaaaaga   1192740
gtttctggta agactatgtt ttcaggaaca ggagaggatt ggccatccat gcccacactg   1192800
gtggcattaa ctagcaaatc cgactcggca atccttgctt gcagttcaga aacatattct   1192860
aaagcacaca aatccacttt aaaacctgtc tgctcctgta acttgtctag gtaaggtctt   1192920
gttttttcca tagaaacgga acgaacaaag accgaaatct gactgacgcc atccaaaata   1192980
gcctgtgcca agattgattt agccgcacca cctgcaccca gcagggtcat ctttttacct   1193040
gaaattgtaa aagaaggcaa gcacttaaaa aatcccttgc catctgtatt atatccaatt   1193100
aaattgccat tctcattgac aaccgtatta accgcaccaa tcaagcgcgc ttcatcgctc   1193160
agcttatcca aataaggaat cacctgctcc ttatagggca tggacagatt gatgccaaac   1193220
atctggtagc gacgaatatt ggccactgtt tctaccaagt cactcgcttc aatctcccaa   1193280
gccacataag caccgttggt agctgtcgcc tcaaaggctc tattgtggat gaagggagaa   1193340
atagaatgct taataggatt ggcaacaact gcagctaaac gtgtatagcc atcaagcttc   1193400
atccaaaatc tccctgattt ttttcatgct agctagagaa atctgcccag gggcactaac   1193460
ctcatccaga ctggcaaaag accaactcga accagtcaca tccgcagtga tacgagagac   1193520
cttgcccacc ttacccatag aaatggtcac atattcctgt tcaggattga gggttttaaa   1193580
gcctcgtgta tagttcatca agtctaagac atcctgctcc gtgtgagcca tcaccgcaac   1193640
cttaacaagt tttggattta ggatcgtcaa ctctgacaag atttccatca tgttctcagg   1193700
tgtttcttgg aaattatggt aactcaaaac aagatttggg aagtccagca tttcctcaaa   1193760
aacatccttg tagctatagt actcaaaatc aatatagtct ggttgataga gttgcgcaac   1193820
ttccttgatt agatggatat actcttctgg agaaaggtcg atttctccac cttcggagcg   1193880
agttcgtagc gtgaaaacca actcacggcc tgcgaatttt tcaaaaatgg ctggagctac   1193940
ctgcaaaatc gcttctttag gcagatagtc ggcacgccat tcaatgatgt cggcatccag   1194000
gtacctcgtg gcatccagag cctgagcctc ctctaaactt cttggcatta ctgaaacgat   1194060
taatttcatt tactaacctt catactaatc accttgaggt aattactact ttcatctttt   1194120
ttattatagg caaaatctgc tggaagacca tatttgttta aaatctggta acttcttcct   1194180
gcaaaacctt tatcaatttg ttctgtaaat ttctgacggg aaacattggc agcattggta   1194240
ctggcaatga taatccctcc cggatttaaa atctcaagac tctgggaaat caacttgtga   1194300
taatccttgg ccacagagaa agtttgtttt ttattccgag caaagctagg cggatctagg   1194360
acaatcacat cgtaggtcaa gtctttgcgt ttggcatatt tgaaatactc aaagacatcc   1194420
atgactataa aacgatgctc gtctgtgctg agcccatttg cctgaaaatg cgcttgagac   1194480
aattctcgtg aacgtttggc tagatcaaca gaagttgtat ggctagctcc tcccatggcc   1194540
gcagctactg aaaaagccgc tgtgtaggaa aacatattga gtaaggattt acccatagcc   1194600
aagccgtcaa ctaaactacc gcgaacctca tgctggtcta ggaaaattcc tgtcatcaag   1194660
ccatcattca taaagacttg atacaggaca ccattttcta aaacattgaa aaagtcaggt   1194720
gcttcttgac cataaacatg ggcagattca tagtccaaac ccttaaagcg gattttctca   1194780
taagctccta aaacctcagg gaaaacctgt ctaaaggctt ctgatatagt ctgacgaatc   1194840
tgataaacat aagagttata ccaagaaaag acggcgtagt cgccataaag gtccactgtc   1194900
agacccccaa agccatctcc ctcttgatta aagagacgaa aggcagttgt caaatcatct   1194960
tgatagtagg cgtttctctt ttctttggct tttctaaaca acgtttcaaa gaaagcttga   1195020
ttgaaggcca ccttgtcttt gctgataaac cagcccaagc ccttgttttg ctgagaaagg   1195080
taggcagtcc caagaaagtt tccttcctga ccctgcacct ctacttcctg atccttaaga   1195140
ttgacattct caagatcact ggcttctagt aaaactagcc ccttagcaag cttcttttca   1195200
acccttttgc tgactcttat tctattcata actaccatta tatcaaactt ttagacaatt   1195260
ctcaaaaaag aaactaccct tgctttttta ctcttctttt aaaaaatggt atactagact   1195320
tcctgcaaaa ctaggaagta aatgtgtaag aatcacagta aaaaatgctc ttccgtcttg   1195380
gaggagcatt tctttttatc aacgaaaatc aaatagcaaa ctatgaaact agcctcaggt   1195440
taactgtgag attataggta gagaggttgt atcagcaata tgtgtctgtc aaatttagtg   1195500
acaaaggtag tagaagaaag ataaagaaat aaatcagctt cagtaggtat ctggaaaatt   1195560
tgattttata gagaagcctt ttgttacaaa ctcaatatac tatcaataaa taatattata   1195620
gaagcaacaa taattataat ttcacctatc tgcatcattc tatttcgaac tctaaatata   1195680
tgttctatca aaaatacttg gaacacacac attataggaa ttaacgtttt tgaaattgaa   1195740
aaatatccaa ataaataaac tataaacaac aaaaatagaa ctatgttata tttcttattc   1195800
aaaacattcc tccctatata tttttgatta ccaatcttaa tcatttacaa ctacattcta   1195860
acaaactata aaagcgtttg tcgaattgaa tttatcaagc aagcgaccaa ccagttcatc   1195920
ttttttctat ttctgccaat atgcgtgaca ggtaataatg atagccaaaa atagcaagag   1195980
caagcaagac gataagagct cctactccca agctgatggc aaggataggg gagagagact   1196040
gaaccaagaa tatgctccca attacaaggg ccatcaggat tgcactataa ataaacaata   1196100
aaactatggc gactatgcca tttgaacgat tcaccaggtc cgtaatgcta ctccaattgg   1196160
ttgacagatt tttaacgtcc ttaaagtaat ggtggcaaga aaggatgaca ctggcaatga   1196220
tccagactac aagaaggtaa atcatcgaaa tgatgggcaa gcctagatat agagaaagac   1196280
caagcaaagt cagaactggt aaaaaggact ggacagcata tataatccaa aatttcactt   1196340
tcacataacg agcaaagtca aagggtaaac tcttaagaaa atcaacattt tccctctcca   1196400
aggacaaggc aattgaatgc aggctggtga tattgttatt gacaactgct ataaagagag   1196460
ctataaaaaa caagggtaac cagtatggag gatgaatgtc tggaactatc tgagaatctc   1196520
ggattttgga aatcagaccg atcatcatga gataaggaag gaaagcactt gtaaaaagca   1196580
ctgtaatcac gccagtcccc tgtcccaaga gggtgaggtg gtagcgtaaa accatgcgaa   1196640
aaaatccctt tttagtggtt gaaattctct ccttgctgcg acgttctttt ttgaccttct   1196700
cctcactatt aagcaggatc acgtcataaa aacgaggaag gaccttcttt ttggtcagat   1196760
aaagcaggaa gagagttagt cctatccaag cgagcagacc cactaaggct tctgtcgaaa   1196820
aaggctccac tgctattttg taaaagatat gaagaggata aaggagaaat ggaatgtctc   1196880
taactttgtc aacaatactt ccaaaagtcg actgaagaaa gaagataaat attaaaggta   1196940
tgagaactcc tatcccaatc atcacattcg aaaaaataga ctgatacttt ctgaagaccc   1197000
tagtttgagc caagaaatgc actgccacta ccatcactag agccacagag acaaataata   1197060
aggtcaagga cagtagcatc aaaggcaaac ccagccatag agaaggagct agcctaatgt   1197120
agaggaccag aaaataagct aggattggta caattccagt tagagctggc aaaaggacag   1197180
acagtccttt agcaattata atctctgatt ctttaaaggc atagggccta tacgatacca   1197240
aatccttact ctcataaaag acattgtaaa aggccgttaa agaagttgaa aaggcaatca   1197300
ctagtaaaat agcaatcatc gagctaaaat aaataggtat ttcctcaaaa ggaaaatgaa   1197360
tggctatatt actaaaacag atgatcatca agagactgga aaaaatgtaa gaacttaaga   1197420
ctctagcgga aacatttact tttttcccag gattcttagc ctgcttcttt cgtagattag   1197480
ccagattagc ttcttgagat gaataaagga tattgatatc aactaatttt ttaatgacct   1197540
tgagacgcat ccgcaacctc ctcttttcta ccagcaagac taaggtagat actttccaaa   1197600
gactggtctg ggtaatcttt tctcaagtcc tctacactac cacaataaat caaatgcccc   1197660
tttttcaaaa tggcaatccg atcacagact tgctctgcca cctctaggac atgagttgaa   1197720
aacaagactg tcttcccttt ttgtgcatgt tccttcatca tctgtttcaa atcaaaggca   1197780
gcctggggat ccaaaccagt caagggttca tccaagaccc aaatatcggg atcagacaag   1197840
agtgctccga tgacaaagac tttctgacgc attccgtgag aaagagtttc aataacctga   1197900
tagcgatttt cagcaaaatc aaaaacgttc aatagcctag ctagactagc ctccaagtca   1197960
gatctactca gatcatagga tgaggcgatc aattcccaaa attcattggc cgttaagcgt   1198020
aaaaataagt caggcgagtc tgctacgtag ccaatctttc gtttaatagc caagcgattt   1198080
tccgataact cctgaccgtc taccaaaata cgaccactgc tgggtgaaat gatactgact   1198140
agggatttta tagtggtcga ttttccagcc ccattatgac caatcaagcc cataatctct   1198200
ccattttcaa tctgcaaatt gagattactc aaggcctctt tatcaccata caacttacta   1198260
acattttgaa attcaatcat gggacaactc ctatctttat ctgtattata tatcgctata   1198320
ctagcacttt gatacaaaaa aatcaatact ttattttaag tagttaaaat agtttccttc   1198380
tatcttacgc aaacgtttgc gctaatagat actttatgat agaataaaga acaagattga   1198440
caagtaagag gaaacattat gcaaaatcaa acactcatgc aatactttga atggtatctg   1198500
ccccacgacg gtcaacactg gacgcgtctg gctgaaaatg ctccacacct agctcatctg   1198560
gggatcagtc acgtctggat gccaccagcc ttcaaggcaa ccaacgaaaa agatgtcggc   1198620
tatggggtct atgacttatt tgacttagga gagttcaacc aaaaagggac tgtccgcacc   1198680
aagtatggtt tcaaagaaga ctatcttcaa gccattcaag cccttaaagc acagggaatt   1198740
caacctatgg ccgatgtagt tctcaaccac aaggctgctg ccgatcacag ggaagccttt   1198800
caggttatcg aagttgatcc tgtagaccgt acagttgaac ttggagaacc cttcaccatc   1198860
aatggctgga ctagttttac cttcgatggt cgccaagata cctataatgg cttccactgg   1198920
cattggtacc acttcaccgg tacagactac gatgccaaac gcagtaaatc tgggatttat   1198980
ctgatccaag gggacaacaa gggctgggcc aacgaggaat tggtcgataa cgaaaacgga   1199040
aactacgact acctcatgta tgccgaccta gactttaaac atcctgaagt catccaaaac   1199100
atctatgact gggctgattg gttcatggaa acgactggtg tagctggttt ccgtttggat   1199160
gccgttaagc atattgactc tttctttatg cgcaacttca tccgcgatat gaaggaaaaa   1199220
tacggtgacg atttctatgt ttttggtgaa ttttggaacc cagacaagga agccaatctg   1199280
gactatctcg aaaaaacgga agaacacttt gaccttgtcg atgttcgtct ccaccagaat   1199340
ctctttgaag ccagtcaagc tggcgcaaac tatgaccttc gtggcatttt cacagatagc   1199400
ctggttgaac tcaagcctga caaggctgtg acttttgtcg acaaccacga tacccaacga   1199460
ggacaagccc ttgagtctac cgttgaagaa tggttcaagc cagcagccta tgccctcatt   1199520
ttgttacgcc aagacggcct tccatgtgtc ttttacggag actactatgg gatttcaggg   1199580
cagtatgctc aagaagattt caaagaaatc cttgaccgcc tcctagccat ccgaaaagat   1199640
ttggcctatg gagaacaaaa tgactacttt gaccatgcta actgtatcgg ttgggtacgt   1199700
tcaggtgctg aaaatcaatc cccaatcgca gtccttatct caaatgacca agaaaacagc   1199760
aagtcaatgt ttgtcggtca agaatggact aatcaaacct ttgtagattt acttggtaac   1199820
caccaaggtc aagttacaat tgatgaggaa ggttatggac aattccctgt ctcagctaga   1199880
tccgtaagtg tctgggcagt caataccatc taatagctca taataaccaa gctaggtcca   1199940
agcggatttg gcttttttgt attcacaaaa agacctaccc aaatggatag atctttactt   1200000
gattacaatt tacctgctac tgcatccaac aattcttgga tcttaggttg gttgcttcct   1200060
cctgccatgg ccatatctgg tttaccacca ccacgtccat cgatgattgg tgctaattct   1200120
ttgacaaggt ttcctgcatg aaggtctttt gtcttgcttg ctacaaggac attgactttg   1200180
tcaccgatag cggcaactag gacaagaaga tcagagtagt ctttttgttt ccagttatct   1200240
gcaaaagtac gaagggcacc ggcatcggat acagacactt gactagcaat gtaacgatga   1200300
ccgttgactt ccttaacatc tttgaagata tcgcctgcgg ctgcagctgc ggctttttct   1200360
ttcaactcag cattttcttt ttgaagttga cgaagttgtt cttgaagtcc ttctaccttg   1200420
tgaggtactt ccttgacttg aggtgctttc aaggttgctg cgatagcttt aagagcatcc   1200480
tcttgttcac gataggcttc aaaggcttcc ttaccagtca ctgccaagat acggcgagtt   1200540
cctgaaccga ttccttcttc tttgacaatt ttgaagagac caatctcaga agtgttgtca   1200600
acatgagtac caccacaaag ttcaatagag tagtcaccga tagtcacgac acgaacttcc   1200660
ttgccgtatt tctcaccaaa gagggccata gctcccattt ctttagcagt gtcaatatcc   1200720
gtttcaactg tcttcacttc aagtgcttcc caaattttct cgttaacttg ctgttcaatc   1200780
gcacgaagtt cctcagcagt tactgcttgg aagtgggtaa agtcaaagcg aaggaattca   1200840
acttcgttaa gagatcctgc ctgtgttgcg tggtttccaa ggatattgtg aagggcagcg   1200900
tgaagcaaat gagtcgcagt gtggtttttc atgacacggt gacggcgatt gctatcaatt   1200960
gccaaggtat attcttggtt caaggcaagc ggtgcaagga cttcaactgt atgaagggct   1201020
tgaccatttg gggctttctg aacattggtc acagtagcca caaccttacc tgactcatcc   1201080
aagatttgtc cgtagtcagc tacctgtcca cccatttcag cataaaatga cgtttccgca   1201140
aagataagag aggcagttcc ttctgaaaca gctcctactt ctgcattgtc agcaacgata   1201200
gctaccaatt tagaagacaa ttggctagca ttgtagttga agacactttc tacagtgatg   1201260
ttttgaagag tttcattttg catacccatt gagccaccct tgacagctga cgcacgcgcg   1201320
cgttcttgct gttctttcat ggctgcttca aaaccttcac ggtctacagt cataccagct   1201380
tcttcagcga tttcttcagt caattcaact gggaacccat aagtatcata gagtttgaag   1201440
acatctgaac cagcgataac agattgacct ttttctttca agtctgctac aatgccttgg   1201500
gcaaagtgtt gacctgagtg aagggtacgg gcaaatgatt cttcttcgct cttaacgatt   1201560
ttctcaataa agtcacgttt ctcaagcact tctgggtagt agctttccat gatttttcca   1201620
acagttggaa ccaatttgta aaggaaaggc tcgttgatac ccaatttttg accatgcata   1201680
gaagcacgac ggagaagacg acgaagaaca taaccacgac cttcatttcc tggaagggca   1201740
ccatcaccga tagcaaatga aagagaacga atgtggtctg cgataacctt gaagctcatg   1201800
ttgtcgccat cttggtcata aaccttacca gacaatttct cgacttcacg gataatcggc   1201860
atgaagaggt ccgtttcaaa gttggtctta gccccttgga taacggccac caaacgctcc   1201920
aaaccagcgc ccgtatcaat gttcttatgt ggcaattcct tgtattcgct acgaggaaca   1201980
gcagggtctg cgttaaattg tgacaaaacg atgttccaga tttcaatata acggtcgttt   1202040
tcaatatctt ctgcaagcag gcgaagaccg atattttctg ggtcaaaggc ttccccacgg   1202100
tcaaagaaga tttctgtatc tggtccagaa ggtcccgcac cgatttccca gaagttgtcc   1202160
tcaattggaa tcaagtgact tggatccact cccacttcaa tccagcggtt gtaagaatct   1202220
ttatcgtctg gatagtaggt catgtaaagt ttttcagcag ggaaatcaaa ccattcaggg   1202280
cttgtcaaaa gctcataagc ccaagtgata gcttcgtcac ggaagtaatc cccgatagag   1202340
aagttcccca gcatttcaaa catggtatgg tgacgcgcgg tcttccctac gttttcgatg   1202400
tcgttggtac ggatagcctt ttgggcattg gtaatacgtg gattttcagg gataatggtc   1202460
ccgtcaaagt atttcttaag ggttgctacc ccagagttga tccacaaaag agttgggtca   1202520
tttacaggaa ccaaacttac tgatggttct actgagtgac ctttggtcgc ccagaaatca   1202580
agccacattt ggcgtacttg tgcactagat agttgtttca tattgtctcc ttattcactt   1202640
gtttaatgtg attggctttc cagcatttcc acatagtcaa tcgcgacaca gagggaaatg   1202700
actaggtctg cataagcgtc ttcaagaacc gttacggtat aggtagaagt cagatggaag   1202760
agttccttct taatttccgc aatcaactga tcgcgatcat ccagcaattt gaaattcaaa   1202820
tcccagatat tgccctcgat acgaagacct agattatcaa actcatactt atctcgccag   1202880
aaggtcaact tcttacgaat gacaaaactc gagccatccc gaagctgaat ttcaaaacga   1202940
ggaagcaagg tcaagatttc tttactaatc tcactgactt gttcaccagc cgcatcatag   1203000
atggtaaagg ttttaggaat cttaaaaaat gatccctcca cctgataggc aatttctccc   1203060
ctgtcatcct tgatagcgaa gcgttcgcct ccaagacgaa acttttgttt gacaagaaat   1203120
gttttcatca acacctccaa aaatcaaaag acaagctcat atcacgaagg gcgaaaaacc   1203180
gcggtaccac cttcattcaa tgaacttgtc attctcttgt tcttatgcaa ttgtatgatt   1203240
gagtagcatg acttcctagc ttagatggct cgcagcaccg ccatttctct ggactaagac   1203300
aagtgaaaat caattctcaa ctttcttatt ataacgtttt tttaagcttg cgtcaactgg   1203360
aaatgatctc cgttgaatta gaccaattcc ctacatctct gattactttt tcaggatata   1203420
ttttttctta ctgccatttt tctttttatc ccaaattttc atattactaa acacagctac   1203480
tagaatattt ccaaatataa aggtgcctat cacccaatat atggactcag ttgttaggta   1203540
ttgtcgatcc aagccatcct ttaaatggaa tagtatagca gtttggttaa caatcataaa   1203600
ggttggccag aaactttttt tgaaaaaagt agacattttc attatttgtt gccgctttct   1203660
gtaaggttaa tactcaataa aaatcaaaaa gcaaactagg aagctagcct caagctgtac   1203720
ttgagtacgg caaggcaacg ctgacgtggt ttgaagagta taggcttagt atactactag   1203780
gcaagcaaat aaacaaataa acaactagaa tagaaaaaga tagggctcta aaaactgact   1203840
tctattcctt aaaaacgaac cagcttgact gattcgtctt cttacgttta tctcctactt   1203900
ccgatacatt ttaaactgta ggaagaggtc gctatatttc cctgtccatt tatggtcaaa   1203960
tttctcataa acttctaggt gtttcatggt ttcaacatcg ggatagaagg ccttatcttc   1204020
ctttgtttcc tctgggagca attccttcgc tggtaggttt ggtgttgaat agccgacata   1204080
ctccgcattt tggagagcat tttcaggttt caacataaag ttgataaagg cataggctga   1204140
gttttggttt ttaactgttt tgggaatgac catattgtca aaccaaagat tgctggcctc   1204200
tgtcggtacc acataacgta gattttcatt tttttctaac atttggctgg cttcaccaga   1204260
gaaggtcacg ccgattgcaa cattattctg aatcatatag cccttcatct cgtccgcaac   1204320
gatagccttg atatttggag tcagtttgta gagcttatcc actgtctctt ccaactgctg   1204380
cagatccttg gagttgaggc tgtagccgag ggaattgagt cctagtccca gcacctcacg   1204440
cgccccatca aagagcatga tagaattctt atactccggc ttccaaaggt catcccaatg   1204500
ctcaggcgct tcatctacca tggtttcgtt gtagacaatt cctaaggttc cccagaagta   1204560
agggatggag aatttattac ctgggtcaaa ggactggttg agaaactctg gtccgatatt   1204620
ttcgattcct tcaatttttg aataatcaag cggaaccaag aggtcttcgt ccttcatctt   1204680
gttaatcatg tattcacttg gaatggcaat atcgtaggtc gttccaccct gctttatctt   1204740
agtgtacatg gcttcgttgg agtcaaaagt ctcgtactga acttgaattc ctgtttcttc   1204800
tgtaaactga gtcaagagtt caggatcgat atagtctccc cagttataga taaccaattt   1204860
ttgactatct cgactattga ttttactatc taaatgagtc gcaattcccc acaagacaag   1204920
gataatcgct gcaattcctg ctaaaaatga atagattttt ttcatgcttg ctcctccttc   1204980
tcacgagaga taaagtaata acctacaact aggataatac taaagagaaa gactagagca   1205040
gacagggcat tgatttctaa ggaaatcccc ttgcgagcac gagagtaaat ctcgactgat   1205100
agggttgaaa agccatttcc tgttacaaag aaggtcacgg caaagtcatc taacgaatag   1205160
gtgaaggcca tgaaataacc agtaatgata gacggagtca ggtaaggaag catgatttcc   1205220
ttgaacatct gaaattgact agctcccaag tcataggccg catgaatcat gtcgccattc   1205280
atttccttga gtcgaggcaa gaccatcaag accacgatag gaatggagaa ggccacgtga   1205340
ctagatagaa cggtcaaaaa gccaagtgaa aacttgagtt gggtaaagag aatcaagaag   1205400
ctagcaccaa tcataacgtc aggcgcaacc atgaggatat tattgagtga tagaaaggct   1205460
tcttggtatt tcttacgaga ctggtagatg taaatggcac caaaagtccc gataatggtc   1205520
gctatcaagg ctgataggaa ggccaagaaa aatgtctgag ccaaaatcag catgagtctc   1205580
ccatctccaa acatggtttc aaagtgagtc cagctaaaac ctgtaaagct attcatatca   1205640
tcaccagcat taaaggcata gccaatcaag taaaagatag gcaggtagag gaccagaaag   1205700
accagtccca gataaaggtt ggcaaatttt ttcatcgttc tctcctttcc ttagtcaccc   1205760
acatggtgat gaacatggtc aggatgagaa tcacaccgat ggttgaaccc ataccatagt   1205820
tgtcattggt tagaaaattc tgctcaatag ccgtccccaa ggtgataacg cggttcccac   1205880
caatcaaacg ggtcagcatg aagagactca aacttgggat aaagaccgac tgaaccccac   1205940
ttcgcacacc gttcatagat agagggaaga tgacatgacg gaaggtctcc cacttagttg   1206000
caccaaggtc ataactagca ttgatgagat tattatccat atcgtctaag acattgaaaa   1206060
tcggcaaaat cataaagggg agctcgatgt agcttgcgac aaagataaag gaaaaatcgg   1206120
taaaaagcaa ctgttgtgaa ccaattccga taaattccaa gaattggtta atagagccat   1206180
tttgaccaaa aatcccgata aaagcatagg ctttaaggag caaattgatc caggtaggaa   1206240
ggataatcag catgagccag agttgacggt gtttgagacg ggtcaaaaag agggccgtcg   1206300
gataactgat aagcagtgcc acaaaggtca caatgcctgc ataaagcact gagttgaaac   1206360
tcattttaag ataggtcaag ttttgtgacg caaagtaaga tttgtaattt tctaaactga   1206420
actggccttc gatgttgaaa aaggattgac cgaaaatcaa gaccaagggt gccaatacaa   1206480
agagcgcaat ccaaagcatg tagggtacta caaagagttt agagcttgtt ttcttcatct   1206540
ctttcctcct cgattgcatt gatcaaacct gcttcttgct cttcgatttc tacgtactcc   1206600
tcaatacgag catcgaactc ttcttcggtt tcattgagac gcatgatgtg gatgtcttct   1206660
ggttcaaagt ccagaccgat ttcctcaccc acgatagcct tacgggttga gtggatcatc   1206720
cattcatttc caagttcgtc ataggcgata atttcataat gaactccacg gaaaagctgg   1206780
gtatcgacct taacttggag cttgccttct tcaggaaggg taatgcgcaa gtcctctgga   1206840
cgaataacga cctcaacagg ttcatttggc ttcatcccac catcaaccgc ttcaaagcgt   1206900
ttgccgttaa attcgaccaa gtagtcctca atcatggtac ctggcaagat gtttgactcc   1206960
ccgataaagg tggcaacaaa gtggttgatt ggctcatcgt agatgtccac aggggttcca   1207020
gactggacaa tctcgccatc attcataacg aaaatccagt cactcatggc aagagcttct   1207080
tcctgatcgt gagtgacaaa gacaaaggta atgcccaatc gttgttgtaa ttcacgcaat   1207140
tcgtactgca tgtctgttct caatttcaag tccagcgctg ataaaggctc gtccaacaag   1207200
accacacggg gttggttgat gatagcacgg gcgatggcca cacgctgacg ttgtcctcca   1207260
gaaagtttgc ggatggaacg tttttcataa ccttccaact gaaccatctt gagaacttcc   1207320
gctacacgct gctcgatttc tttcttatca attttacgca agcgaagtgg aaaggcaaca   1207380
ttttcaaaca cattcatatg tgggaacaag gcataggatt ggaagacggt atgtacgtcg   1207440
cgcttgttgg ttggaatatc attgatacga acaccgtcta gcatgatatc tcctgtcgtc   1207500
gcatccagta aacctgcaat aatgtttagg atagttgatt tccccgaacc agatgcacct   1207560
agaagggtgt agaatttccc ttcttccaac tcaaagttga tgtctttgag aaccttggtg   1207620
ttgctgtctt caaaaacttt agagacgttt ttgaattcga taattggctt tttcaattgg   1207680
cataaattcc ttctttttca tagattaacc gatcggggct ctgtcaggtc cccactacct   1207740
cttgcaggga gtaaaaccac ctgcatacat cttcgctacc gataggcttt cacccaagat   1207800
ccggacttct ctttcaagcg taatacctga gtgttccttg actttttcga taaccgattg   1207860
gatcaagtcc tcgtagtctt tggccgttcc atctgcgaca ttgatcataa atcctgcatg   1207920
cttttctgac acttctacgc caccgatacg atagcctttc aagccagctt ctgaaattaa   1207980
ctgacctgca aaatgcccga ctggacgctt aaagaccgag ccacaagatg ggtattccaa   1208040
aggttgcttg agttcacgta ggtgcgtcaa gcggtccatt tcctgcttga taacctgatg   1208100
ggttcctgga gctagggcaa atttaactga caagacaact gcaccagact cctgaatagc   1208160
tgaatgacgg taaccaaaag ccaagtcttt agcagacagg gtttcgattt ctccatcctt   1208220
ggtcaagacc ttacaagact gcaagatgtg agcaatctcg ccaccatagg cacccgcatt   1208280
cataaagaca gcaccgccaa cgcttcctgg aataccacaa gcaaactcaa agccagttaa   1208340
actatgacgg agggcaatgc gagttgtttc aatcaagtta gccccagctt ctgcttcaat   1208400
ggtatagcca tcaacagaaa cgttattgag cttgtcacac aagatgacaa atccacgaat   1208460
cccaccatca cgaacgatga tattgcttgc attgccaaga accatccaag ggatattttc   1208520
ttggttggca aatttcacaa cgcgagccaa ctcaaaacga tttcgtggaa agaccaaata   1208580
atcagcctct ccacctactt ttgtataact atagctatgc aagggttcct taaaacggat   1208640
atcaattcct tctaagattt caagcatttt ttctcttaca gacatgtcac tcttcctttt   1208700
acaaaattca ttccattata ccatttttag agacatttga cgaccataaa aataccttgt   1208760
ttggattttg cataagaaaa agaggttccc ccctttttat gattttttac aaaagatttc   1208820
cttggttcca taggcgacca gaacgagctc cagtgctaga atcacttcaa ccaagactgg   1208880
atttgtcaac cagcctactt ggaaaagaga tggtgccaga tcaaagaagg catgcaagcc   1208940
ataggctgct aggagataaa tccatttctt ctggcgaaca gcttggtaaa cccaaactgt   1209000
caaaagtaat tggaaaccaa gcgccaagat tcgctcaaaa ccaagcaaat aaatctgcca   1209060
gaccgaaagt gactgaatgg tttttaacat attttcagac agtaattgca taacctgtgg   1209120
attctgagtt tgaactgccg aaagaacaat gtaaagattg agtaaactag taaggcctag   1209180
aaaaatcaac tccaagccac catgccccag tccataggcc aaggcgtctg ccttttccaa   1209240
acttctcttt ttctccaacc atttgaagaa aacaagacga gccgtttcct caaaaaatgc   1209300
tgccatggct aggccataga taatatagat aagcggatga tcttgcaaga gggcaatact   1209360
accgtctttt tgagggtgca aaatcaagat atgcaccagt ttttccaaaa tctgcgaaga   1209420
gacaaagaaa gcgactgcac ccaagcccaa gacagctaga ttaatctggt atttcttttt   1209480
ggcaaaccaa atgcttccta tcagaaaagc tagcaacagc aacatggtaa taatgatatg   1209540
aatggtcatt ttcttctcct attctgcctt ttcaatatct tttttcatct cgtcaacatt   1209600
gaacttagca aacaagtatt gacggtcttg gactgggaaa cgttggtcca actggtcaac   1209660
tgctcccacc tcgataatgc cttccttgat gacaaaatcc atgacatgtc caccgaaggt   1209720
caaatcatct gatatgaagt gcagatggta gcctgccaca ctgaccccat ggaaaatctc   1209780
aggcgtccag aaaccaacaa tagtccccgc aacattgtca cgactatatt ccggttgatg   1209840
ggttgcgaca tcagcaaact tggtatcggg tgttgactta ggaatcatac gcacatgcat   1209900
atgtaaaaat tccccccgaa tcttgataga gcggaaaaga ttttccccat cataataaga   1209960
ctcaattcgt tctttcaatt ccttgtctgt catctcaaag cgctggcgga aaatgacctc   1210020
tgcccgatgc ggtaccactg cagcgtaagg aataagggca tctggtgaca cttccacaat   1210080
ttctggctgg tctcctgacc ctttggcctg ataagccttg ccatccaaga caatcaattc   1210140
cccatcaatg gaatccaagg ttcccaaacc aaggtcacca tgttctagca attctcctac   1210200
tgtcatagta ccaccataaa ggccagccat caaggctcca agagtattgt attgaaataa   1210260
tttcactggt tcctgcacgt tcttatccat tcactttctt gtctgttatt ctataaatct   1210320
tactcctaag tataccacat ttgcccctag atgtgaacga gagaaacgct ctagacattg   1210380
ccaagaagga aaaaaaaggg tacaatgtaa caaaatcaag ggaggtctgg aatgaagaaa   1210440
caaagcaagt acaaagaggt cgtttcctat ctgaaaaatg gtatcgagtc tggacgattt   1210500
ccgacgggta gtcgcctgcc ttctatccgt caactgagcc ttgactttca ctgcagcaag   1210560
gacaccattc aacgagccct gctggaatta cggcacgaac aatacctcta tgccaagcct   1210620
cagagtggct actatgtatt agaacaaggg caacatcaag acctagaaat cgaggttacc   1210680
gacgaacatg ccagtgccta tgacgatttc cgactctgtg tcaatgaaac cttgattggc   1210740
cgagaaaact acctcttcaa ctactatgac aatcaagaag gattagaaga cctaagacag   1210800
tccattcaca aactcctctt tgagcaagct ctctactgca aggctaacca actagtactg   1210860
acttctggaa cccaacaagc cttgtttatc ctctctcaaa tatcctttcc tagacaagcc   1210920
aaggaaatct tggtggaaca gccaacctac catcggatga atcgcctctt gattgcacag   1210980
gggctggact atcaaacgat tgaacgaggc attgatggga ttgacttgga ggagctggaa   1211040
ggccacttca aaacaggaaa aattaagttt ttctacacca ttccccgatt tcactatccc   1211100
ctgggacatt cctattctga gcaagacaaa cgatctattc ttaacttagc tgccaagtat   1211160
gatgtctata tcgtagagga cgattatctg ggtgatttgg actccaagaa gggccaaacc   1211220
ttccactatc ttgatacaga ggagcgtgtc atttatatca agtccttctc gaccagcctt   1211280
tttcctgccc ttcgtattac agcactcatt cttccaaatg ctatcaaaga agcatttgtg   1211340
gcctacaaaa atatcctaga ctacgacagc aacctcatta tgcaaaaggc cctgtcactc   1211400
tatattgaca gtcaattgtt tgaaaaaaat cgtttggctc gcttgaccaa tcatgaatct   1211460
taccaaaaac aaatcgagga aaggataact aaaacacctt gtccccttcc tcattattcc   1211520
ctacacgatg gtttattgct agacctgaga cagtatccta aaatcgccag tctcaaacac   1211580
agtcaactgg gcttggactt ctttgaagag gcctatttaa gcacctgtcc ttatcaattt   1211640
gccaaggtgt ccctagacaa tctggaaaat gttttaaact atttaaaagc agaattggaa   1211700
tgacatccaa ctctgctttt tcttattctt caacttcagt tagacttgct gctttttcaa   1211760
gatagctttg gtaagttcct tcatccttaa gtttttggac gaccttgtct accacttctt   1211820
tcaaatcatc actatttttt ctaagagcaa cggcattggc gtcgccgtcc ttcatcttca   1211880
agctgacagt tgcgacagct aagccagcgt ttttagcagc ataactaagt gcaacaggct   1211940
catccatatg aacagcatct atttttccag cctgcaattc attgactgct tcacccatat   1212000
tagttaggga agttaattga acttttggca attgttcctt gaccattgat tctggaacag   1212060
tccctttttg ggctgcaata ttagcacttt ctaggctagt taaatccttg tatttttcca   1212120
catcagcctt acgaaccaag aaactaatct tgttttcata gtatgggatt gaaaaatcaa   1212180
agacttcttt tctctcgtca gtagcactaa ttcctgcaac tgctaggtca gccttaccag   1212240
tttgaagact ggtcaaaaca ttgtcaaaac tcatgcttga gatttccaac ttaaccccaa   1212300
gttcatcagc gatagcctga gccatgtcga tgtctgcacc gactacctgg ttctttccat   1212360
caaccaatga ttgaaattca aagggtgcat agtcaggact ggttgccaca actaatttcc   1212420
ctttttgttt gatagcatcc acagcagact gagaaccatt agaacctgac tgacaagcta   1212480
ctaagaagaa acttgcaaga aaattacata aaacaaatat ccattttttt gatttcataa   1212540
ataaacaacc tctctgttaa ttttgtataa ttataacgat atccaagtta cttgtcaagt   1212600
gttttttaaa tttttatctc aaaaatattt tttcgttcaa aaaaaggagc catcagttga   1212660
tttcaagctc ccttttatac agaattaaac tattttatag ttcgacaatc ttacctgttt   1212720
caaagtagac aacccattca cagatatttt tagcatagtc accgatacgc tccaagtagg   1212780
aaataacttg gaaataatca cgacccgtaa caatggcttc tggatttttc ttaatctctt   1212840
cagtcgcaag gtcacggata gtttcaaaat agtggttaat ttgctcatcc atggaggcca   1212900
cccggtatgc gtcgtcaaca gaaccattaa gataaagatc aagtgctgct tccacaacgc   1212960
ttttaacttc acgtcccatt tttttaattt cttcctctac agctggaatg cgctcttccc   1213020
ccttcatacg gatggttgcc tgggcaatgg ctacagcgtg atcccccata cgctccacat   1213080
ctgatacagc cttaaggaca gtcaagactg tacgcaaatc ttgagagact ggttgttgga   1213140
gtgcgatcat ttcaaatgat ttcttttcca gtttcacttc gtattcattt acttctgcat   1213200
catcttcgat gacctctttt gccaggtcac ggtcatgcgt gacaaaagca cgtaccgtac   1213260
gattgatttg tgagagcact tcttgtccca tagcgtagaa ctggttatgt aatttctcta   1213320
aatcttcttc aaattgagat cgtaacatct ttcatctcct tatccaaatt ttcctgtaat   1213380
atagtcttcc gtttccttgt gttggggatc aaggaacatc tgcttggtat cattaaattc   1213440
aatcaaatct ccatctagga aaaatcctgt cttatcagag atacgtgaag cttgctgcat   1213500
ggaacgggtt accagaagca tggtgtactt gtcttttaga ccatacaagg tttcctcaat   1213560
tttaccagct gaaatcggat ccaaagccga agttggctca tccaagagga tgattttagg   1213620
actagttgcc aagacacggg ccacgcagac acgctgctgt tgaccacctg acaatccaat   1213680
agctgaatca tatagacgat ccttgacctc atcccagata gaggcacctt gcaaggcttt   1213740
ttctacggct tcatccagaa cctgcttatc cttaattcca ttgatacgaa gcccgtagac   1213800
aacattctca tagatagtca tagggaaagg attaggttgt tggaaaacca ttccgatttc   1213860
cttacgtaat tcaaccgtat ctgtacgcgg actgtagatg ttgtgaccat tgtacaccac   1213920
ggatccagtt gtggtcacct ctggattgag atctcccatg cggttgagag acttgaggag   1213980
ggttgacttc cctgatccag atggaccaat caaggctgta atttccttag gttggaaaga   1214040
tagggaaaca ctattcaaag ccttcttttt attataataa acggacaggt ctgatacctg   1214100
taaaatcgca tctgtcatac ggtttccttt ctaaccaaag tgaccagata catagtcatt   1214160
ggtggactgt agcttggcat tttggaaaat agttgcagtc ttgtcatact caatcaaatc   1214220
acccaagtaa aagaagcctg tatagtcact tgcacgagca gcctgctgca tattatgcgt   1214280
tacaatgatg atggtaaagt ttttcttgag ctcaaacatg gtctcttcta gttgcatggt   1214340
cgcaatcgga tccaaggctg aggctggctc atccattaag aggatatctg gcttaacaga   1214400
gatggcacga gcgatacaga gacgttgttg ctgaccacct gataaggtca aggctgactt   1214460
gtggagatcg tctttaacct gatcccagag ggcagcctga cgaagggagg tttctacgat   1214520
ttcatctagg acttgcttat ccttaactcc agcacgttca tgcgcaaagg taatattacg   1214580
gtaaattgac ttagcaaatg gattgggacg ttgaaaaacc attccaatgt gtttacgcat   1214640
ttcataaacg ttgatttctg gacggttgac atcaattcca cgatagagaa tctgcccagt   1214700
tactttagca atatcaatag tatcattcat gcgattgaga ctgcgtaagt aggtagattt   1214760
ccccgatccc gacgggccaa tcaaagctgt aattttattt ctttcaaatt gcatatcaat   1214820
ccccttaatg gattcatttt taccatagta aacatggaca tccttagtag aaagggctac   1214880
tttttcttca ggaaaggtaa ggatatgctt ctcatcccag ttatatgttg acatggcttc   1214940
tcctttaggc agcggttaat ttcttgtgta gatagcttcc gaacttacga gctccaaagt   1215000
taaaaatcag gataaagatc aggagcacag cggcagaacc tgctgataca atggttccat   1215060
ctggaatagt gccttcacta ttgactttcc agatatggac agccaaggtt tctgcttgac   1215120
ggaagataga gatggggcta gtcacactga ggatattcca gttagaccag tcaagagctg   1215180
gcgccgattg ccctgctgta tagatcagag ctgcagcttc gccaaagata cgaccagatg   1215240
ccaagacgac acccgttaca atacctggaa gcgcttccgg aataacaaca tgaaccactg   1215300
tctcccagcg agaaatccca agagccagac cagcctcacg ttgggtatgg tgaacgtgtt   1215360
tcaaactatc ctctacatta cgcgtcatct gaggcaagtt aaagactgtc aaggccaagg   1215420
cacctgaaat gattgaaaat ccatactcaa actggactac aaagatcaag taaccaaaga   1215480
gacccaccac cactgatggt aaagaggaca aaatttcaat acaagtccgc acaaagttgg   1215540
taacaggacc ttttttagca tattcagcca agtaaatccc agctcccata gaaagaggta   1215600
cagaaataat caaggtaatg accaatagga aaaaggaatt gtaaagctga atgccaatcc   1215660
caccacctgc ttgaaaagca gaagaccttc cagtcaagaa agaccaagag atatggggca   1215720
agccccgaac caagatatag agaatcaagg aagccaagat tgtcacaatg atgctagcaa   1215780
tcgtatagag gacagctgtt gcaagtttat ctaatttctt agcgcgcata atttttcttt   1215840
cctctttctt tcgtaatcaa tttaatcaca ctgttaaaaa ctaagctcat caagagcagt   1215900
accaaggcca gtgaccagag aacattatta tttacagttc ccatgacagt gttcccaatt   1215960
cccatagtta atatagaagt taaagttgca gctggtgtgg tcaaggaagt tgggataaca   1216020
gctgagtttc cgacaaccat ctggatagct agagcctcac caaaggcacg cgccatccca   1216080
aagaccactg cagtgaaaat accagaacgg gccgccttca agatcacacg ccagatagtc   1216140
tgccagcgag tggctcccat agcgaaactg gcttcacgat aataacgagg aaccgcacgc   1216200
aagctatccg ttgtcataaa ggttacggtc ggcaaaatca tgacaaagag gacggaaatc   1216260
cctgacaaaa tcccaaaacc agtcccacca aagacactgc gaacaaaggg aacgacgact   1216320
tgcaagccaa taaatccgta cactactgaa ggaatcccaa ccaggagttc aatagctggt   1216380
tgcaaaatct tcgccccttt tggtgatact tcggtcataa aaactgctgc accaatagca   1216440
aagggtgttg cgataagggc tgagagaatg gtaacgataa aggaacccaa aatcatagga   1216500
agggcaccaa attctttact agaaggattc caagttcctc ccaaaagaaa gtcaaagata   1216560
ttcacaccat tgacaaagaa ggtcgacaag cctttttgcg ctacgaaaac caaaatcatg   1216620
gccacaagga tgactatcaa agaaagacag gcaaaggtca aaccttttcc taatttctcc   1216680
agacgagaat tctttgatgg aagcaacatt ttcttagcta attcttcttg attcattatt   1216740
gtctcccttc caacactgtc acagttccgg cagcatcttt ttcaaccttc atttccttaa   1216800
tcggaatata cttcaatcct ttgacaatcc cttcttgggt ctcatccgag agaacaaaat   1216860
tgagaaattc tgcagccaac tcattgggct gccccaatgt atacatatgc tcataagacc   1216920
acaagggcca attattgcta cttatatttt ctggacttaa gtcatagcca ttcaacttca   1216980
tgcttttgac cgaatcatct atataggtaa gagataaata agagatagct cctggacttt   1217040
ttgatacgat tgattttacc gctccatttg aatcctgctc ctgactttgc atggcagact   1217100
gaccttccat aatgacagta tcaaaggtag cacgagagcc agagccggct gcccgattga   1217160
taacagagat gggtaagtcc ttaccaccaa cctctttcca attggttacc tcacctatga   1217220
agatttgacg aagttgctct gtcgttaggt tatcaacatc aacctcctta ttgacaatca   1217280
gagccaagcc agctaccgcg accttgtggt caacaagagc agaagcatca attccgtctt   1217340
tttcctcagc aaatacatct gagtttccta tatcaactgc cccagactga acctgggaca   1217400
agcctgtacc agaacctccc ccttggacat tgaccgtttt tccaacatgg atcgtgccaa   1217460
attcatctgc cgctacttca accaagggtt gcaaggcagt tgagccaaca gccgttatgg   1217520
attctccacg atcaatccag ctagcacagc ctactaaaca agccgtcagc caaaaagcga   1217580
taagagacag agcaagcttt tttctttttt tcactgtttt tctcctcgaa aataattatg   1217640
aatactgtga attttttaag tagttcttta tgagttgacg catgaattct taccaaattt   1217700
ctgcgcaatt gattatttat ataatatagg ctatattact ctttcctaac ctcctttttt   1217760
catatgtgga taaaatctct tgtctatccc ttcccccatt gtcacccatt atagtcattt   1217820
cgtgtctctt tttccccttt ttaatgcaag ggaaattact ctccttagat gataatccaa   1217880
aagctagaaa ggtatctcaa acctctctac tctcccagac tagtttacaa ctaaaaggaa   1217940
aagattctat tttatgagaa atctagttta caagcggtaa gaacgctaat aactaaactt   1218000
cttgtactct ttgaaaatct cttcaaacca gtgttttgag ctatctatgg ctagcttcct   1218060
agtttgctct ttgattttca ttgagtagta aaactacatg taatggcaat caagatatca   1218120
agaatcatcc tactaaaaaa atccatactt tcactataac atagaataag atatttgact   1218180
agcattttca tttgaatctg aggccttttg gaaaataatt tttcaaaaca tttccagtaa   1218240
cctttgcaaa gcccaagcca ttgcctttaa ccaaaacttg gtaccaacca tttggcagac   1218300
tttctgccag ctgaacggtt tctccagccg catacttgac aaacgcttct tggccaattt   1218360
caaccgactg ttcgacctga ctcggtttca aggctaaacc aagagcgaaa ctgggctcaa   1218420
agcgtttctt cttaaaagta cccagatgca gtccattgcg agcaatcttg agcttccata   1218480
aatctggcaa aagttctggc aagagataaa gctggtctcc aaaaatctgc aagatacccg   1218540
gtagattgac cttcaaatgg ttttgggcaa attcctgcca caaggcaact tgttcacggc   1218600
tgaggttact cttacttgcc ttaaatttag gagctggatt gttaccctta aactgtagat   1218660
gggcaacaaa ctgaccctct cccttaaact gatgaggata catccgagcc gtttctggca   1218720
ggtcaatacc agctaccatt ccattgatat gctctactgg caacaagtca aaatcatact   1218780
cttccagcaa ccaattgaca atctcttcgt tttcctcggg tgcccaggta caggtcgaat   1218840
aaaccagatg accaccttca gctaacatgg tcactgcatc ctccagaatt tctctttgca   1218900
agctagcaca ttgactcgga taatctaagc tccaatagtc catagcatca ggttgcttac   1218960
gaaacattcc ttcaccagag caaggggcat caagaacgat taagtcaaaa tagcctttaa   1219020
agaccttgac caagcggtcg gcagattcat tggtcaccac gacatttgtc gctccaaaac   1219080
gctccatgtt ttcaaccaaa atcttagccc gtttgcttga aatttcattg gaaacaagta   1219140
gcccctcccc tgctagatag gctgccagtt gagttgattt gccccccggt gcagcagcca   1219200
agtccaagac cttcatacca ggactgggtt gggctacttg agccaccatt tgagcagcag   1219260
gttcttgcga ataaactaaa cctgtagcat gctcaggcga tttccctgaa accttcccat   1219320
agtggcccca aggggtttga gtaatggcat cagaaaagga aagttgctct tcttttaagg   1219380
gattgacccg aaaggccgaa accgcttcct cctcaaaaga ggcaagaaaa tctcttgcct   1219440
catctcctag tatctcttta tatttttcaa caaatccttc tggaaattgc atttaagttc   1219500
ttttcctttc gtaaatatag gactgaattt cctcctgcat ctcaagaggc accatcatga   1219560
ccggctgtct ggtttgaaaa tcaggagctt caccaaaaag ggtcacaacc cgatagccca   1219620
gactttcccc taaaatacta gctgcggcat aatcccatgg ttgcagataa gtgagatagg   1219680
tcaacaaacg ccctgacaaa atcttggcaa aactaatggc cgcacttcca tagacacgaa   1219740
caccaagaac cgctcggctc aaatcagcca gcccccattc attggtttcc agcataccac   1219800
tattccctgc aatgagaaaa tctccaagtg gtttagtttt aaaaggagct agggacctat   1219860
catttagaca aactggaaat tccccaccac cgtggtaaca atcccctttg accacatcat   1219920
aaatcagacc aaactgtccc tgaccatttt caaaataagc catcataaca gcaaaatctt   1219980
cctgctgggc tacaaaatta ttggtaccat caatgggatc aatgacccaa accttgccct   1220040
cttgaaccga ggctcgcaga caaccttctt cagcacaaat cttatcctca ggataacggg   1220100
acaaaatctc accaaccaag agttcctgaa cttctttgtc cagtctggtc accaaatctg   1220160
ttggagagga cttggtttca acacgcaagt cttcctgcat atggtcaaga atgtactgac   1220220
ctgctttctt aacaagctct ttagcaaatt caaatttact ttccaagaga aatctttcct   1220280
tccccttttt ctttggcagc ctgaactgct cggtaaagtg aatagccact aaccgtttca   1220340
aattctcgtc ccaaacgttt ctcttcgctc ttgcttggca cgaccgcttt gaatccctta   1220400
taggagtcca gtaacttttt agcctctact ttgccttcat aggcagcttc aacatcatta   1220460
aaaaaagaaa gcactgaagc aagttcttca gtgctccacg acaaatctag tgggtaacta   1220520
tactgtttgt tcattaacta ataccagctc tcattcttgc ttcttttagt tcttgcttac   1220580
gataactacg agggagaaaa gcacgaatct catcttcatt aaaaccgatt tgcatacgct   1220640
tggcatcaat aataattgga cgacgcaaaa gactaggata ctgctcaatc aaatgaagca   1220700
attccgatac cgaaatactc tctacatcaa tattcaattt ttgaaaaatt tttgaacgag   1220760
ttgaaatgat gtcatcagta ccattttcgg tcaaggaaag gatgtgttgc aattcttttc   1220820
ttgttaaagg actggtcata atattgtgtt ccacaaaggg aaccttatgt ttttctaacc   1220880
aggccttagc cttacgacat gatgtacagc tcggtgatag aaatagtgta atcatgcttt   1220940
tctcttctta tctatacttt gctacttcta ttatacaaaa aaataaagcg cttgactagg   1221000
gatttttaga aaaaaagcct attttttcaa gaaaaatagg ctttttgcga acgattgaca   1221060
caattggatt tggttaattc actcttaacg atggttttaa acgatatata tttttatata   1221120
tgtaaattaa aaacatcttt cctttcactt cctacgactt ttcagataca gatagccaaa   1221180
gaagttttca tagagggcaa aaaagaggag gaaggcatga agaaagaagg tctctggcaa   1221240
aatcataata acaggatcct tggctggatc aaaaagccag gtatcatctc ccacaaagag   1221300
aatttgatgg aaaagagtaa agaattggtc aaaaccaatc aaaactcccc caagtccaat   1221360
catcacaggt aagactacta gagccaggag actttttcga taaagagaca aaaagtcctt   1221420
tttcacaatc ctattgacaa agacatagaa acttggcagt gtcactagag ctactagctg   1221480
aaccaaatga aagagattct tgaccactgc gaaatggtgc agaccagctg ctgacgaacg   1221540
aaaatcaggc atctgtaaga cctgactaaa aggattggtc agataattca tcaagatatg   1221600
aaaattgtat tgaatggttt ctggttttag atagactcga ttcgttaagt ttagccactg   1221660
aatctccata ggatagaaaa tccaagccag ataaatggtc agaaggatgg agagggagag   1221720
gagaaagagc atagagcccc aaaagatcaa tttagttttc atcaaaatcc cactccgcaa   1221780
ggctagaaac cacatgtgtc ggtgcgattg gcaggccagc tacttcttct gccttagtaa   1221840
aacctgtcgt caccaagagc gttggaatgc cattgtcaat cccagcccga atatcagtca   1221900
aataattgtc cccaaccatg attaactctt cacgttccaa acctaagtgc tcaaccgcct   1221960
tgtccataat gatggcattt ggttttccga tataaaccgg cttcactcgt gtcgctactt   1222020
caagcagcgt aatcagtgag ccagcacctg gcaaaagacc gcgttccgtc gggatgttga   1222080
ggtcaggatt ggttccgata aaatgggcac ccttttgaat agcaagagtt gctgtggcaa   1222140
atttttcata gtcgacttgc caatccagac caactaccac gtaggcaggt ttttccttgt   1222200
cttccacata accagccgcc ttgatggctt ccttgagtcc tgcttctccg acgacataga   1222260
cggtcttttc aagccccaaa tcattcatat agtcgatggt tgccaaagtc gctgtgtaga   1222320
cagtcgatag gggcgtatcg atattaaaat tctgagccaa catctcctta acactctctg   1222380
gagtgcgggt tgtattgttg gttacaaaga gatagggaat gtcccgcttt tgcaattcat   1222440
gaacaaaagt ctctccagca gggattcggt ctttcccctt ataaatggtt ccgtctaaat   1222500
caattaaata gcctttatat ttcatctatt tctccctaag ccttttttat ttcttgccaa   1222560
gtaatgattg cttgggcatt gataacccca tcacttgtaa tttcatgctt gctttccagt   1222620
ccagtccgtt caacagccga tgtaatcacc ccacctggtc gaacttcctt gacatacttg   1222680
aggttgattt tcttgggaat atagtgggtc aaaaaatccg ctcccatgac ctcaaaaatc   1222740
cagtccaagt atttactgtt attgacatga ccattcatat ccaagtcgta aaaacgaaca   1222800
tggtaatcct tgctgatcgg ttcttccaag gactcatact tcggtccacg gataagtttt   1222860
ttatcaaaat cagactggta aggagccaca atctcaggtt caacaacatg gacttttcga   1222920
ctgtcgcggt ccatgagaac aaaggtcgcc atcatgtgga tgagctcctg ctccgcttca   1222980
ttataaatag taaagcgacg gtagcaaaaa agtcgattgt agctcaaggc ttccgtttcg   1223040
atggtaattt cttccgcaaa acgaggcaaa cgaaccacct caatatcata ttctacgata   1223100
atccagacca gattatattc ttccaaaatg gccttatcac taactcccag ttcaatcgac   1223160
tgcatccctg aaacttgcag tgacagcaaa atcacatctg gaagtttgat atgaccgttc   1223220
atatcagcca tatcaaaagg aattttcatt ttcatttgat aagttaagcc catgatccta   1223280
ctccaaaata aatcgttctg ctacagtatc tcccaaaaag agacctctct ttgtcatgcg   1223340
aacgtggtca ccctcaatct gcatgaggcc ttgttgaacc aaatctctga caatttctcc   1223400
ataaagtcca gcaaaagact gtccaaattt ttcctcaaat cgcgccatgg aaaccccgga   1223460
tttcttgcgg agtcccaaga acatttcttc ttccatttgc tccttttgac tcaggtgatc   1223520
ttctgtaata caagcattgc cttcctcaac cgcactgaga taatgacgaa tgggaccatg   1223580
atttttatag cgtactccat tgacataacc agatgcccct gcaccaatac catagtattc   1223640
agcattgtcc cagtacatga gattatgacg actttcaaaa ccgggtttgg agaaattaga   1223700
aatctcataa tgctcaaaac ccgctcgctc cagctctgca atgatgtact caaacatctc   1223760
cgcttctagt tcctccttag gcagaggcaa tttcccacgt cgcatccggt tcataaagac   1223820
cgtatggttt tctaaaatca aactatacaa actcatgtgg ggaatatcca atccaatggc   1223880
tttagccaca ttttccttta cttgctccat ggtctgacca ggcagagcat aaatcaaatc   1223940
aatggagata ttgtcaaaac cagccagttt caggcgatcg atattttcat aaatatcctt   1224000
ctccaaatga ctgcgcccaa tctttttcaa catcttatca tcaaaggtct ggacacctag   1224060
cgaaacacga ttgacagccg aatttttcaa aacagctatc ttatccgcat ccaaatcgcc   1224120
tggattggct tcaatggtca actcttccaa gacagacaaa tccaagtttt tagtcaagcc   1224180
attcagtaac acctccagtt gcggagccga cagggctgtc ggtgttccac caccgatata   1224240
aagggttgac aacttttcaa tatcataaga acgaaactct tccagcagat gctctaaata   1224300
gctgtcgact ggctgatttt tgatgaagac ctttgaaaaa tcacaataat aacaaatctg   1224360
ggtacaaaat gggatgtgca cataggctga cgttggtttt ttctgcatag taattattat   1224420
accacaaaga ctagattcca gataaaaatc accatcccca gatacatagt ccgtccggag   1224480
atggtgatgg tttattcttc tgttatatca atcacaatct cttctgagtc atcaagagct   1224540
tcggcttttt cttgccattg ctccttgaga ttatttaatt gattttttga tgcttctgtc   1224600
gcttgaaaag cataggattt agtttgagca agtatactgt ccacagtgat ttcacctgac   1224660
tcaacctgtt cttttgtttt cagaacaaaa tctgtagcct gctccttaac ttctgtcagt   1224720
ttttcacaga cttgctcctt ggcatactcc ggatcttctc tcaaatcatc tagaaaatct   1224780
tgagcctgac tgcaaacttg tttgccctta tcacttgtta aaaacaaggc aagagctgca   1224840
cctgaaacgg ttcctaaaag gattgaggat aatttaccca taaggattct ccttttttat   1224900
tttttgaaaa atttacttgc aagacgaaga gctgacagac ttgcaccagt cttgagtgtt   1224960
tttgaaccag ctgatgaagc tttcttgctc aagacacgcg catggtcatt gaggtctgaa   1225020
acagatagag ataaatctgc aacagcactg aagagtggat caatcgtagc caccttgaca   1225080
ttgatatcat ctgccaagac attgacctta gccaacaact cattggtgtg atgcaaggtc   1225140
acatccacat ctgaagtcaa ggttttaatc gtcttttctg tttcatcgat gacacgacca   1225200
agcttttgta cagtaatgat cagatagacc aaaaagacaa tcaaagctag ggcaacaaga   1225260
atatatgcaa cttctaacat ttagttttcc tcctctgtaa tatagtaagg ggccttcttt   1225320
cgattttgat aaataacgat cattataccg agaccgataa ggacaactga cagccattgg   1225380
gacactcgaa agccgaagaa catgagacta tctgttcgca taccttcgat aaccatacga   1225440
ccgaaaccat accaaatcaa gtaaaaggcc gtgatatgac ctcgtctgag actcttccat   1225500
ttccgtctaa aaatcagaat caaggcaaag ccaagcagat tccatagaga ctcataaagg   1225560
aaagtcggtt gacggtagct cccctcaata tacatctggt cacggataaa gccaggtaga   1225620
taatccagat tatccactgt tgcaccataa gcttcttggt taaagaaatt accccaacgc   1225680
cccaaacttt gagcaatcat aacgctaggc gccgcaatat ctagaaaatc ccaagtattg   1225740
atgagtttac ggtcagcaaa gatatagagc acaagagccc cagttatcaa accaccgtaa   1225800
atggccaaac caccattcca aatggcaaaa atctctccta aattctgact atagtaatca   1225860
aatcggaaaa taacatagta gagacgagct cctaaaatag ccaagggaaa ggctactaag   1225920
ataaaatcta aaatatcgtc tggtatgatc ttctttctag gtgcttcttt catggtcaaa   1225980
taaaccgcaa gaatcaagcc tgtcacaata cataaggcat accaacgaat ggctaggggt   1226040
cctagttgaa tagcaattgg atcaagcatt ttgcacctca tttcgagcga ttagacttgt   1226100
cagtcgttcg tcgaacaaac gggtcgcatc aaagcccatt tccttggcac gataattcat   1226160
ggcagctgcc tcaatcacaa cagagatatt acgacctgtt ttaactggaa tacgaatacg   1226220
aggaatgtac gccagaaact tcaagttcct ctgcattatt tccaagacga tcaaaggtct   1226280
tatgcgtatc gtaattttcc aaatagacag caagctgaac ctgtgaagaa tccttgacag   1226340
cactcgcacc gtagagactc ataacatcga taataccaac cccacgaatt tcaatcaagt   1226400
gtttcaaaat ttcagctggt tcaccccaga gagtaatctc atccttggca aagatatcga   1226460
cacggtcatc ggctaccaaa cggtgaccac gtttgacaag ctcaagacct gtctcgctct   1226520
taccaattcc actatctccc tgaatcaaga cgcccatccc ataaatatcc atcaagacac   1226580
cgtgcacact ggtacgttct gccaaacgag aatccagata gctagataac tctccagata   1226640
aacgactggt agctgcacgg ctggttaaaa tagcaatctt acattctcta gcagccttta   1226700
acatctcctc tggaaccacc aaaccacggg caacaatgac tgctggtgtc tcaggtagaa   1226760
acattttttt caaaacttca taacggctgt tggaaggcat gctgatcaga taagaccact   1226820
ccttcatccc caaaagttga atccgctctg gtgtatagta gtcaaaatag cctgtcattt   1226880
caagaccagg tcgcgtaata tccgctgtat tgatttcctt ttcaagcaat tctggttcac   1226940
catagacaat gtctagtcta agcttttcaa tcacttcttt tactaaaacc gacatcattt   1227000
cctccttcaa atgagttctt ctctctatta tatcaaattg taggaggaag tttcagattt   1227060
ttgcaggctt tggagtattt atttaaaaga aaaaggacta gatttctcta gcctttcatt   1227120
tcaattagaa ttttttacgt ttacgagcta cttctgattt acgtttacgt tttacagaag   1227180
gtttttcata gaattcacgt ttgcgtgttt cttgaagagt accagcttta gtaaccgcac   1227240
gtttgaaacg gcgaagtgcg tcgtcaagag attcattctt acgtactact gttttagaca   1227300
tttttttcac tcccttcaag ttcaagatct attctatttt acacgtaaaa ggaataattg   1227360
tcaagcaaaa atgcggttta attttgattt tttcttccat ttatacaaga gttgaaagcg   1227420
ttcaatagaa cattgctttt ttatttttag agtaagctaa gcgcttcagc atctgcgatg   1227480
atggttacat cagggtgatt ttggaggcta cttgcaggta ggttctcagt cactgggcca   1227540
gatactgttc cggcaatggc ttctgctttc gactcaccgt aagcaaaaag aataatagac   1227600
ttggcatcca aaatgttttt aatccccatt gaaatagctt gggttgggac gtcttcaatc   1227660
ttggcaaaga agcgtgcatt ggcttcgata gtagactggt caagttctac tagatgcgtt   1227720
tgactgtcaa atggagtgcc aggctcatta aagccgatat gcccattgcg accgattccc   1227780
aagatttgga ggtcaactgg atggtcagcc aaaatttggt tgtagcgttc aacttcagct   1227840
tcagcattgt ccttaacacc acgaggcaag aaactttctt taaatggttt ttggttgaac   1227900
aagttttctt gcatgaagta acgataagac tgtggattgt ccccatcaag gcccacatac   1227960
tcatcaaggt tgacactggt tagatttgaa aaatcaaggt cactctcaac aatttccttg   1228020
taaaattcaa gtgggctact tcctgtcgca agtcctagag tttgagctcc attagccaat   1228080
ttttccttca aaatctcaaa agcaactttt ccaccttgaa cttggttttc aactttaata   1228140
actttcatct tttcatcctc catttttgtc tatatttatt atatggtata gaccaatttt   1228200
tgtcaagtga aaacgattta atttctaaaa aaagagcgtc caaacttgaa acgtgttata   1228260
atggatagga ttagaactta gaaagaatga acaaatatat gaatacagct gattttgatt   1228320
tccacttgcc agaggaattg attgcccaaa cgccccttga aaaacgtgat gcctccaaac   1228380
tcctcatcgt caaccgtgag acaggagaaa tgcaagataa acatttccac tctattattg   1228440
atatgctgga acctggtgat gcccttgtca tgaacgacac ccgagttctc cctgcccgcc   1228500
tctatggtca aaaagtggag acaggaggtc atgtggaact tctcctcctt aagaacacta   1228560
gtggagacga gtgggaagtt ctggctaaac ctgccaaacg cctcaaggtc ggtactcgta   1228620
tcagctttgg tgatggccgc ctcagcgctg tcgttacaga agaattgacc cacgggggac   1228680
gcattgtccg ctttgaatac caaggaattt tcctagaagt cttggaaagt ctgggagaaa   1228740
tgcctctgcc accttatatc cacgaaaaat tagatgaccg tgaacgttat caaaccgtct   1228800
acgccaagga aagtggctct gctgcagcac cgactgctgg tcttcacttc accaaagaac   1228860
tgctggcaga aatccaagct aagggtgttc atctagtcta tctgactctc catgtcggac   1228920
tcggaacctt tagacctgtt tctgtggata atctggacga acacgaaatg cactcagagt   1228980
tctatcaact ttctgaggaa gctgctgcca cccttcgctc tgtcaaaaaa aatggtggtc   1229040
gtgtcatcgc tgtcggaacc acttctatcc gcaccttgga aactattggt tccaagtttg   1229100
atgggcaaat ccaagcagat tctggttgga ccaatatctt tatcaaacct gggtatgagt   1229160
ggaaggtcgt ggatgccttc tcaaccaact tccacctgcc aaaatcaact ctggtcatgt   1229220
tggtttctgc ctttgcaggc cgtgaattag tcttagatgc ctaccaccat tccatccaag   1229280
aacactaccg cttcttcagt tttggtgacg ccatgtttat ttattgagaa agaatttctc   1229340
taaatcttct aataccaata aatcgctaag atattatttc aaagaacatc tacaattgaa   1229400
actctagcta gctgtagaag aggcctagta cattgaaatt aaaatgcttc cccctagctt   1229460
cgaaaatatt gccatagatt gcgttgactc tccaaattga ttcatctata ttttatttca   1229520
gcttcctata ctttcttcgc tgtttgtaaa tcaaaatgca agacacatga gtagcaccat   1229580
atttgttact cttatctgtc ctctcaagag actattatga gttatttcag aatcattcac   1229640
tactttgacc ctgactctcc ttagtctcaa aatcaaagac ttatactctt caaaaatctc   1229700
ttcaaaccgc gtcaacgtca ccttggatta tatatgtgac tgacttcgtc agttctatct   1229760
acaacctcaa agcagtactt tgagcaacct gcgactagtt ttctagtttg ctctttgatt   1229820
ttcattgagt attaaacaaa aagtgaacaa atctgaattc taatgtacag aagactaggc   1229880
ttgttcactt ttttatagtc gctataagat gaccttatct atagcttttt atatataatt   1229940
atatattcag acatactatt atcaattttg tcgcagggag gaatctgtta acgcacccat   1230000
tcaccattat cattgactct atagccatct atacttgtat tgaccgctaa ctcacccgat   1230060
gtatttacat aataccattt accaccaact tggaaccatt gattgacttt catagaaccg   1230120
ttgctgttga ggtagtacca tgaactatta acttgtaccc aacctgttgc catggaacca   1230180
tcagtattat aaaaatacca cataccattt tcttgtttcc agtctgttgt tggagcaact   1230240
gctttagctg gttctactgc tacatctgtt ccttggttag atgtaacaga tacaggatac   1230300
gaaggaatag atgattgctc aggaacaaca actttttcag gttctctcgt ccctctcctt   1230360
atacgtcttt ttaccatctc tttagtaatt tgacgagaag tagtttcttc aattgttcca   1230420
tcacgttcat ctacagtata gattgtagta agagtaattt accaatttct cctacttctt   1230480
ctacttcttg acttttatca agagttgggc catcgagata ttctgtttcg attggaattt   1230540
cttggacaag aacttggggc ttggttcttt ttttaacaac tcttgtttga gagtcttttt   1230600
tttgacttaa agtactctca gttacttgtc cactctttcc atctacatta taagttatcg   1230660
ttgtaactgt tttcccattc tttcctagag taatctcttg ctcctgtcct gcagaaaggt   1230720
cattgtctgc ttcatattta gtagcaaatg gaacaagaac ttcttcaacc ttgcttttag   1230780
ctggaacttt gataactgta tccgtggctt cttttctatc aacagtaacc tgttcggtaa   1230840
cataaccagt ctctggatta acatcgtagg tccttgtcgt agttacatag ccatcctctc   1230900
catcaattgt aacaggattt tcactacggt cttttgtttc atctttttca taacgaattc   1230960
gcgtacttga aattttcttg gttactacct taggtttagt cgctactttt acaataatat   1231020
ccccattgtc agcgtcatca tactctattc cctcttcttt atctctagta tcatctctga   1231080
catattgaat cccatcagca gcatgaacaa aacttgtatt cagattcctc ctaaaaataa   1231140
agttagcccg attaccgcag aaccaaaaat ctttccgagt ttacgtattg catagcgctt   1231200
attagtatta gattttgcca ttacatccta cttctagtat agcatctttt ctatcaaacg   1231260
ttaaacaata tactttatat ataaaataga cttagaatga tatattgatt attgaactaa   1231320
cactttaact atatcgtaat caatctcata tataaaggat tgcagacatc ttatctaaat   1231380
acatgctaat atatttagat acaaacattc caacttgata attttcactc atctttcatc   1231440
attccttata caactatgca gtataaatag aatagttttc tcatcagaat gagactattt   1231500
taatattaga tccccaatta ttcaccccaa atctaaaaac catccagaat ccttgcctta   1231560
gcttagatcc tggatggttt cttttttcac ccaatgggtg ttttttacta gacaaaaaag   1231620
agtttcccct ttatggtata agtgtagaaa aaaacacaaa aagaaaggaa actcacatga   1231680
acagtttacc aaatcatcac ttccaaaaca agtcttttta ccaactatct ttcgatggag   1231740
gtcatttaac ccagtatggt ggtcttatct tttttcagga acttttttcc cagttgaaac   1231800
taaaagagcg gatttctaag tatttagtaa cgaatgacca acgccgctac tgtcgttatt   1231860
cggattcaga tatccttgtc cagttcctct ttcaactgtt aacaggttat ggaacggact   1231920
atgcttgtaa agaattgtca gctgatgcct actttccaaa attgttggaa ggagggcagc   1231980
ttgcttcaca gccaacctta tcccgttttc tttccagaac tgacgaggaa acagtccata   1232040
gtttgcgatg cctcaacctt gaattggtcg aattcttttt acagtttcac cagctaaacc   1232100
aactcattgt agatatcgat tctacccatt tcacaactta tggcaagcaa gaaggtgttg   1232160
cttataacgc ccactatcgt gctcatggct atcatcctct ttatgctttc gaggggaaga   1232220
caggttattg tttcaatgcc cagcttcgtc ctggtaatcg ttattgttct gaagaggcag   1232280
acagctttat cacacctgtt ttagaacggt ttaatcaact tctctttcga atggatagtg   1232340
gctttgcgac cccaaaatta tacgatttaa ttgaaaaaac agggcaatac tacctcataa   1232400
aactcaagaa aaatactgtt ctgagccgtc ttggagacct ttccctccct tgcccacagg   1232460
atgaggactt aaccatcttg ccccactccg cctactcaga aactctctat caagcaggat   1232520
cttggtcgca caagcgtcgt gtctgccagt tctctgaacg aaaagaagga aacttgttct   1232580
acgatgttat ttctctcgtt acaaatatga cgagtggaac aagccaagac cagtttcagc   1232640
tttatcgtgg acgtggtcaa gccgagaatt tcatcaagga gatgaaggag ggattttttg   1232700
gcgataaaac ggatagttca accttaatca aaaacgaagt tcgtatgatg atgagctgta   1232760
tcgcctacaa tctctatctt tttctcaaac atctagctgg aggtgacttc caaactttaa   1232820
caatcaaacg cttccgccat ctttttcttc acgtggtggg aaaatgtgtt cgaacaggac   1232880
gcaagcagct cctcaaattg tctagtctct atgcctattc cgaattgttt tcagcacttt   1232940
attctaggat tagaaaagtc aacctgaatc ttcctgttcc ttatgaacca cctagaagaa   1233000
aagcgtcgtt aatgatgcat taaagaacag tcgagatgaa aaaatcgtgt gacgcaccaa   1233060
gggaggagtc tgcccttttg aggaaatcta gcgaggaaaa acgatactgg aacagcagaa   1233120
agtaaaactg acctcatgag gaggaagaaa gtggctcatg aggtcagggg ttttgtaagt   1233180
tacatctagt tgagagaggt atgaatgatt tgggaatagt tttctcatca gaatgagact   1233240
attttaatat tagataattt gatagaaaaa acatgaataa aattggttga atttaattcc   1233300
ctaactcgat agaggattct attttaaatt taacaacagc taggattaca ctataaaaag   1233360
tacattacca cctgttcggc tggagaatct agtcgattag ctccctctta gttacaagct   1233420
taaagcgatt ttttaactaa cactaaacca gattaaagaa ggaactagaa catctgtctt   1233480
gtactaatca atatgctatt ttaaagtttc aaataaactt ggaatgctaa ttattatatt   1233540
tacaataaat agttgacttc gatagaaaca gaaaatagaa ttcaacattc ttccctactt   1233600
ataccataat aaataagatc cgcaagatag ccttttctct ctacaccatt aacaatggtt   1233660
tgtagatagg acattccagc cttttccatg acacgacctg aagctgggtt gagactggca   1233720
taacgtgctc tgaccttttg aaaacctgct tgagtaaaac aaaagtccaa gatagctttc   1233780
aaagtctctg tcatcatacc atttccccag taagccttgc ctaacacata gccaatttca   1233840
cagcttaaat cagcctcgtc tatcttaaca atgctgatat ctcctattac ttgctctggg   1233900
ttttctttta gacaaatggc ccatttataa tagttgagat tagtatagga agcaacccaa   1233960
ttgcaaatcg agtttcgagt gatttcgaca tcaggatggg gatcccaggt aacataggtc   1234020
agattctcag cggatgaagc ccaattttga aacatggctt ctgcatcact ctccacaaat   1234080
cttcttaaaa tcaaacgttc tgtctgtaat atttgcgtac cgatagattt catgatgcta   1234140
cctcacttcc ttatttctat actcgtagta aaaaggctca actcagtaac agctagaaaa   1234200
cgagtttgtc ttctaatttc ttgacgcagt tgctgcctgg tttgaaatgc gctctagcaa   1234260
gctttttcaa acctagtcat cgttgcaggg gtaagacgat gaaatcgaac tcttcgagtt   1234320
actgaatctg cctcattttc ttatttctaa actcggggtt caagatcccc cagaccttct   1234380
ctcactttct tatttcaaga tgagaggctg aaaacctcca gtggaggttt ttcttgcttt   1234440
ttaatttcag ggcaagaagc taaaaaggtc ccccggacct ttttactccc aaaagtcatc   1234500
aaatacggtg atgggtaagt ggcgtttgtg ttggcctttg tgccaccagt tttcaatggt   1234560
cgcttgagct tctgggctga ttgttttgcc ttctaggtag tcgtcaatct ctgcgtaggt   1234620
gactccaagt gcgacttcgt cagctaggcc tggtttatct tcttctaggt ctgccgttgg   1234680
gattttttca taaagggctg gctctgcgcc aagtttctgc aagagctgtt ttccttggcg   1234740
tttattgagg cggtaaagag ggagaatatc cgcaccgccg tcaccaaact tggtaaagaa   1234800
acctgtgata ttttccgcgg cgtggtctgt tccaatgacc gctccgctat gggaaccagc   1234860
aagggcatac tgagcaatca tacggcaacg tgccttgata ttccccttgt tgaagtctga   1234920
aacaggacta cctgtcgctt caactgcagc tgtcatggca tcagctgatt ccttgatatt   1234980
cacaaccaag ctgacatctg gctggatgaa ggctagggct ttttgagcat ctgcttcatc   1235040
agcttgcact ccgtatggca ggcggacagc gataaatttg tagctatcgt ctcccgtttc   1235100
agctcgcagt tcttccatag ctaattgcgc caaacgtcct gccaaggttg agtcttgtcc   1235160
cccagaaatc cctagtacaa aggtttttag gaagggatgt tttttcagat atctttttaa   1235220
gaaatcaata gaacgacgga tttcttcctg ggcatcaatc actggtttga cacccagctc   1235280
ttggataatc gtttcttgca aactcattct tcttctcctt caccaagggc ttccttgcgc   1235340
atcttatcaa tcaagtccat cttatcttgc catacatcac gcgccaaatc cactggatag   1235400
tgctgcggat tgagcacacg cttatactca tcccacaact tgtcaaattc cttacgggca   1235460
taatcctgaa tgtcagtcaa actaggcaag ttgtaaacta atattccttc tttgaagata   1235520
tccaccaaga gaggaacggc atcaaaatta cgaaccgtct tcttgatgta tgtataggtc   1235580
ggatggaaca tcttgatttc tgtcatgtcg ctaatatcca caccatcata agtgatatag   1235640
tcgccttctg acttgccttt ttcacgactg gtaatgcgcc acacctgctt cttacctggc   1235700
gtagaaactt tttcagcatt attagacagc ttaatcgtat tgcgcatctg accagtttca   1235760
tcttcgattg caacaatctt gtaaaccgcc ccaagagccg gctggtcata ggctgtaatc   1235820
agcttggtac ccacacccca gacatcaatc ttggcctttt gcatcttgag gttaaggatg   1235880
gtattttcat ctagatcatt agaagcataa atcttagcct ctgtaaatcc agcctcatcc   1235940
agttgctgac ggactttctt agaaatgtag gcaatatccc cagagtcaat ccgcacaccc   1236000
ataaagttaa tctgatcacc cagctcacgc gccacctgaa tggcagctgg tacaccgatg   1236060
cgaagggtgt cataggtatc cacaagaaag acacaatttt tgtgggtcgc agcgtaagcc   1236120
ttgaaagctt catagtcatt gccataaacc tgtaccaagg catgggcatg ggttcccaaa   1236180
acaggaatgt caaagagctt acccgcacgc acgttgctgg ttccattggc gccaccaatc   1236240
acagctgcgc gtgttcccca gatggccgca tccatttctt gagcccgacg tgtcccaaac   1236300
tccatcaagg gttcatcttc gataaccgaa cgaatacgag ctgccttcgt cgccaccaaa   1236360
gtctggtagt tgacgatgtt caaaagagcc gtttcgacca actgacattg ggctagaggt   1236420
ccttccacct gcacaatcgg ttcattagca aaaaccaaat ccccttcttg ggcagaacga   1236480
acggtcaact ccaacttgaa attgcgaagg taatccaaga acgccccatg ataaccaagc   1236540
gactccaaat aggctatatc actatctgaa aaacgcaagt cttcaagata gttcacaatt   1236600
ctttctaaac ctgcaaaaac cgcatagccg ttcttaaaag gctgttggcg gaaatacacc   1236660
tcaaagaccg ccttcttatt gtgaatccct tggtcaaagt aaacctgcat catgttgatc   1236720
tggtacaagt ccgtgtgcaa tgtcaaacta tcatctggat acatactttt cctacttcct   1236780
tagctagaaa cccatgaaaa ttttcaagaa ctttcatgta ttccaataaa ttagtactat   1236840
tatatcacat tttagctgga ttgagaaaag agtaacaagc tattctccac tctccaattc   1236900
atccatatct tgttcaaatt ttttctgagc ccattcgcca tagctcttaa gaccaagatt   1236960
gccaataaag atccacggaa ggtaaatgat ataagtaatg acccaagcag acaggtattt   1237020
aaaattcaaa ggattgtgct gataaatttc tatgttgaat tgataattct gcaacatcaa   1237080
aagagccgta atagccaagg ttaggaaaaa acaacccaaa atcgtaaaat gaaaacgacc   1237140
atagtaggtc actcccagat aacgggcacg attgaaaaag taaaatgtcc ctatgatgat   1237200
aacgattagc agcatattag aattaaaaag gcttggtgct aatactgaaa tgatataaga   1237260
taggagcgac aaagcaatgc agatatagaa actttcagag cccgctttat tgaacagttg   1237320
ttcttctctt tcgtctagta attgagaata ataaaatcta tttttcatct tcttcctccc   1237380
aaaatagttg gtctagggtt ttccctaaac atctgcaaat agactggcag agcgagagac   1237440
tgggattgta ttttcccgcc tctattaaac caatagtctg gcgtgtcacc ccgacagcct   1237500
ctgccagttg accttgtgtt aaatcacgct ctacccgagc taattttaat tttaaatttt   1237560
tagccacctt cgtcctcctt atagttttaa tactcatcta ctcttaaaaa atccaaaacc   1237620
aacacaagct atcagctatt tattataacc ccattaattt gcactccagt attatcttca   1237680
gccgaaaatc agtattttag gttgtttgaa ataaacttcc tagtttactc ttttattttt   1237740
atttagtatt agctttagta agatctttta aacgaatttt tattgcttat atttcttgtt   1237800
tagtttagtt ggtttcatat cactattata taatgctttt ggaaatgagc ctagtataag   1237860
tcaaaaacgt gttgaatagt gaaagcagga gcataccaag atgactgatt ttttactgta   1237920
ttttaggtat gcaaaataat actaaatgaa actaaaatga atacttcttg cttttcttga   1237980
gagtgaaaaa gtacaataaa atgattgtag tgattagcac aagatactga ctaatagaca   1238040
tcgtatttga agccacaaat acaggtaaag aataaaaaag gaagaagttc aattgctttg   1238100
ataaacaaat cattactagt attcatcatc atcgtattta atatattaga gataaagagt   1238160
agtaaagcta ctaaaatacc aaataccaag ccacttttca atttgtataa atagaaaatg   1238220
taagataata gaaaataaaa caggactaac aaaattgtat tgactacaat agctactata   1238280
aaatttaatc ctaaatcacc tggaataccc aatttactta ctatgactag taacacaatg   1238340
ccattcaaag cataaataat ggaaactgag atagcatata gaaaattaga caagacgtaa   1238400
atcatccgat tcttctgttt atttaatttc atgattataa ccttccttta ttttgaacga   1238460
tttaggtaaa tatctttaag cgtctctttt ttagtttcaa aatcaactac tttaatagag   1238520
ttttcgttaa aaaatttaaa aagctcacta ttttgaatat tcccagacat agtaattctc   1238580
aatccctctt cctaaacaat atcccaaaat tcttgtttgg taatgaaaat gtctctatct   1238640
gtagctgatg aaaaagctat ctcaaacaag aaattatgac tatcttttcc tactttttga   1238700
aatgtcaaaa gcccgttctc caagaaaaga actctctcac aaatttcttc aatgtcttct   1238760
aatttatgac tcgatattaa aattcccaca ttttcatgta aagctaattt ttttagaacc   1238820
gctaaaacta tttgtgatga ttcaatatct aaaccattag tcggttcatc taaaatcaat   1238880
atatcaggtt ccgtaacgag agttagaagc aaagctaatt tttgttttgt acccaaagaa   1238940
taggtcttta cttttttatt aatagactga gtcaaatcta actcttggat caaacatcta   1239000
aatctttctt gattgtagtc aacaccatat aaatttgaca aatattttaa attctctaaa   1239060
cctgttttag ataaaaataa ttttggttct tcgattaaat acccaacatt atcactgctt   1239120
ataatattac ctgaagtcgg ttgattattc tgaacaagaa ttttcatcaa cgtactctta   1239180
ccaactccat ttctccctgc tagaccaaca atttcaccct tgttaagtgc aaaatttata   1239240
tctttgagaa tgattgaatg accataatgc ttacttacat tttttattcc tccattaata   1239300
ttattggttt tctctttgat tctcattaat tttaaaaagt tgcgcctctt tttaacaata   1239360
ttatatcata tatctaactt aatgcaatat ataaatgtca ttttgtgaaa ttttattaac   1239420
aaaaaactct ctacaacaaa ataatagaga gttttctgct tattaatttt tttcaaaata   1239480
tctaagacat cgcttctttg tttaatttga taggctttga tgcctaaact ccgactttat   1239540
cacttaaaaa ataaaaaaga cagctaatct cttgcgcatc aagggatttc gccattcttt   1239600
aatctcgttt aagtgttgta tatggagctt tgcatagttt tttaaaacta aacaactaca   1239660
ttaagcacga actgtgacgc tggttccatc ttccttataa agattgataa gcccctcttt   1239720
aagagctcga accatgtctc ctgattgaac aggttgtggg actttaatag tcaatagttc   1239780
cattggattt ggagcgcggt cgattttatt gcctttagca tcatgcaaat cttcaatata   1239840
ggtttcaaaa tgacggaaac ctggaccata aaactcaact tggtcccctt cgttaatgac   1239900
gtttcgttga cgaatagttg ctgtttgtgc cgcatcatca taagaaacca cttcagcgac   1239960
aaacttgtac tcagggattt tacgacgagc accaaacaac tgctcatttt cagatggtgt   1240020
accatagtaa aatcctgtag ccagttcacg ttgggcaacc ttccacatct cgtccaccaa   1240080
gtcttgtttg atagcttcaa acttttcagg actttcaaga taggcatcca cagccgcctt   1240140
gtagcagttg gttactgttg atacatagtg aatagactcc atacgtcctt cgatttttag   1240200
actgtccaca ccattttcaa tcatatctga gatatggtca atcatagaca tatcaacggc   1240260
tgacattgaa aattcttctg gaatctcacc ctgcaaactc ttacgttctt tcccaaatgg   1240320
catatcgtaa aggtcgtact tccaacggca tgactgagaa catccaccac ggttggcatc   1240380
acgcatactc tagacggatt gttttgacaa ttctaacctt ttagactttg cataataact   1240440
attaaacagt cgaaaattaa cccagtttta acaagtagtc aaaataccag ataaaggaaa   1240500
aaagtcttta aaatcttaaa aacgcatagt atcaggtatt gaacaatctt gatattatgc   1240560
gttttattgt gggaagattt acttcatttt ctcttgaaat tgagttttct cctacttcaa   1240620
aactagatga tttgctattt aaaatagcgt tccttatgat tttggcaacc tggattaaag   1240680
cgagaaaaac aaaaggggca acttaagctt tctttatatt gcttatatgt tagtagtttt   1240740
agacaaacac cacataaaat aggcttatcc tgtatcaaag ataagggata cggctcaaaa   1240800
gggtgatgtt ctaatgaatc atgacaccga taacaagcat aatacttttt acaatcatag   1240860
cattgtaaag caataatatc cagcttgcta tggtaatgaa tgcatcttgt ttgcttatcc   1240920
actaagaaac cctgtgcctc tatcatttcc ttttcctttc ttaagctcga actgtgacgc   1240980
tggttccatc ttccttataa agattgatga gtccttcttt taatgcacga accatatctc   1241040
ctgattgaac gggttgaggc accttaatag tcaatagttc cattggattt ggagcgcggt   1241100
cgattttatt gcctttggca tcatgcaaat cttcaatata ggtttcaaaa tgacggaaac   1241160
ctggaccata aaactcaact tggtcccctt cgttaatgac atttcgttga cgaattgttg   1241220
ctgtttgtgc cgcatcatca taagaaacca cttcagcgac aaacttgtac tcaggaattt   1241280
tacggcgagc accaaacaac tgctcatttt cagatggtgt accatagtaa aatcctgtag   1241340
ccagttcacg ttgggcaacc ttccacatct cgtccaccaa gtcttgtttg atagcttcaa   1241400
acttttcagg actttcaaga taggcatcca cagccgcctt gtagcagttg gttactgttg   1241460
atacgtagtg aatagacttc atacgtcctt cgatttttag actgtccaca ccattttcaa   1241520
tcatatctgg aatgtggtca atcatagaca tgtcaacggc tgacattgaa aattcttctg   1241580
gaatctcacc ctgcaaactc ttacgttctt tcccaaatgg catatcgtaa aggtcgtatt   1241640
tccaacggca tgactgagaa catccaccac ggttggcatc acgcatactc atgtggtttg   1241700
aaagagtaca acgtccagag tatgaaatac acatagctcc atggacaaag gcttcaattt   1241760
caacatctgt acgtttgcgg atctcagcta attcttccat tgaaacctca cgcgctaaaa   1241820
cgacacgagt caagcctagc tctttccaga actcaagggt ttcatagtta gtggcactgg   1241880
cttgggtaga aaggtggatt tcaaggcctg gtgcttcagt cactgcaatc ataatcaagg   1241940
ctgggtcaga tacgataact gctgcaatcc cgatatcacg cagtttacgg aaccactcac   1242000
cagcaccagc ttcatttcct tcgtgcataa ccatattagc cgctacatag accttggcac   1242060
catacttggc cgcaaactgc acgccttctt ccatctgttc gaaagtaaag tttcccgcac   1242120
ggctacgaag accataggcc tgaccaccga taaagacagc atctgctcca tactgaacag   1242180
ctacctttag cttctctaaa gtccctgcag gtgataaaac ctcaggacgt tttaatgttt   1242240
ttgtcatgat ttctcctatt tgcaatataa aagtttgaca tttttccttc tcattttata   1242300
gtaaataaag gataaaatca agcctagacg gattgttttg acaattctaa tcttttagac   1242360
tttgcataat aactgttaaa cagtcgaaaa ttatcccagt tttaacaagt agtcaaaaag   1242420
tctagaaaag taaaaaccag tatcccaaga tactgactcg taaaaataca taaattagtc   1242480
cttagatgac tactcccact ctgttgctcc tataatggaa aaggattgat acagtctaga   1242540
atatcgcttt tttatttatt attctgatat aaaactgtta gaattgattt tttgttttat   1242600
acccaaatat gaatagagac gtagctaata agttgaataa catatttgga aaaatgagaa   1242660
atagcaatat tactagaact tttagaaaca atcaatattt aaaaagaaaa aagctcaaag   1242720
aatttattaa accatgttat aatagatata gctataattt tatttataac aagaggatag   1242780
aaatgaccga attagaaaga aaaaatcgaa aaattagcta agaaatattc tgataactta   1242840
aacatcaaag ttcaagagag agttcgtgaa atggcaaatg ataataagag ccattatttg   1242900
atatacagag ttttaggtat ttcatttgaa gaaggagaaa atatcgattt gtatcaaaat   1242960
aaaggtcgtt ttttatacaa atatgctggt tcatttttag aagaagctgc agtactatgc   1243020
tttaacgaaa aatttggtac agaaaatact taaaaagtta acattcctaa ttctgaaagt   1243080
acaaaaccta agacttttga aattgattgt ttagtcggag aaaaacacgc atacgaaata   1243140
aaatggtggg atgcaactac agatggagac catataacta aagaacacac tagaataaaa   1243200
gttattcata acaaaggata tataccaatt cggttaatgt tctactatcc aaatagaact   1243260
caagctataa aaattcagca aactttagaa acattgtata acggtattgg agggaaatat   1243320
tattatggag attctgcctg ggaacattta agagcagtga ccggtattga tttacttagt   1243380
attctaacag atattgcaaa taaaaaaaca ggggtaaaat caaaatgaca gtattaaaag   1243440
gagataactt agaaatatta aaaactattg aatcctcaag tattgattta atctatatgg   1243500
accctccttt ctttacacag aaaacccaaa aattatctaa taacaaaaat attatgtatt   1243560
cattcgaaga tacgtggact tcgattgagg attacaaaga atttttgtct gtaagattag   1243620
aagaatgcaa aagagtgcta aaaaatagtg gcagtatttt cgttcattgt gataaaattg   1243680
caaatcatca tattagatta attttagata atatctttgg agtagatatg tttcaaagcg   1243740
aaattatatg gaactataaa cggtggtcta attcaaaaaa gggattattg aacaatcatc   1243800
aaaacattta cttttattca aagtcaaaag attttaaatt taatacaatt tttacagagt   1243860
attcttctac tacaaatatc gaccaaatac tagtggaacg aaaacgagat ggaaactcta   1243920
aaactatata taaggttgat aataatggta actatattct agcaaaagag aaaaatggag   1243980
ttcccctttc agatgtttgg aatataccat ttcttaatcc aaaagctaaa gaaagagtag   1244040
gttatcctac acaaaaacct attctgttat tagaacaaat tataaagatt gctactgata   1244100
aaaatgatat agttttagac ccgttctgtg gaagtggaac tactttagta gcctccaaga   1244160
ttttgaatag aaattatatg gggattgatt tatctgagga agctatcaat ataactcagc   1244220
aacgtctgga aaatgttata aaaacaagtt caaatttatt gaataaagga atcgaagcat   1244280
atagaaccaa aactgaggaa gaggaaaaca ttcttaaatt attacaggca aaaattgttc   1244340
aaagaaataa aggaattgat ggttttttac ctaaacattt tcaaaaaaaa ccgataccta   1244400
taaaaattca aaaaaataat gaatgtctga atgagagtat ctctttatta cagaatgcta   1244460
taaactccaa aaaacttgat tttggagtag ttataaaaac tcattcagat aatttattat   1244520
ttgattttga tacgattcct gaaaatataa tagtagttga ccattttgaa cttacaatcg   1244580
aaaaatggtt aagtaaaagt caacagttac tatagtttgc aaattattta cagaaagaac   1244640
aaaaaatgct ctgaaacact gatttcaaag cattttttgt tagtttaaaa ttactcccat   1244700
tcttcttttc caaacgtaca atatatccaa aaccattcaa aatactagat tctatttttt   1244760
ataatatcac taaatccacc taattatagg acgttttcag atttttagtc ccagtcccag   1244820
taccggagaa atattgtttt aatataatat ctctttttgt cttctaagct cttaaaagca   1244880
aaagaacaag taaagagtca agacaaggat aaaaagtcca tattagggca aataaaaagc   1244940
tttaagacag atgacaaatc taagtcaaat aagaaagacc atagcaaagg tgcagagaga   1245000
taaatattgg cggtcttcgg actgccttta tttttttatc catttttcaa atcaaattta   1245060
ttcagactat atatgcacat atacacttaa attcatataa aaacatggct tgtaaaaaat   1245120
tactttaatc acaataatcg catttaaaat tgtgatgttt gcaagctaaa ttacggactt   1245180
cacttggaag ttttcccttg tatcttttat aatagataga aaatttgctg gcagatgaat   1245240
atccaacaga ttctgctatc tcttttatag gtagttcagt gtttaaaaga agagtttcag   1245300
ctacattcat tctttttctt tgagtgtact ctgtaatgct ttgacaatat ttttccttaa   1245360
ataaattttt taatttagta ccactcattt tagatatttt ttcaagcgtg ccttgattta   1245420
cattcgttgc aaaatgatca tctaagaatc ttgctacatc ttcaagtgct ttatcatcat   1245480
caatttcaat tttatatttt tttctattta agtatgtgtc aattactata cttatccatt   1245540
catttgcctt tgctttaaag aaaaaatcag cggcaggagc gtccatctta caatttaata   1245600
tttccattgc cactctttct aaggcctttg taagtattat ttgattcggt tgaagcaagg   1245660
ttgaataaaa agattctgga ttaatgttaa tagatgctaa atgtttttct attagctctt   1245720
ttttaaaacc aatggaaaca gcaagataac aacaattctc gtgtaataaa aaaacaaaat   1245780
tatcttttat attatcaaaa tcaaaagtac atagagagtt tgcggtaata gtttgatacg   1245840
gattaaactt ttctccgttt gcactgacaa tgtaacttga ataaattgaa acatagtctg   1245900
acatactata agtgctattt tgaactactt cctctttgat ataaaaatca tgtatatcga   1245960
taatgaagct gcctccttca taaaaccaat atagtccttc tgcataagtt gaattctctt   1246020
ttttccaaca aaatgtatga cctgcacttg aatacttctc attgttttta cattcatcta   1246080
ctttcatata atcttttaca aaatcataat atgacataac acactatccc ttttagacaa   1246140
tattccaatt agccttatta attcaaaact attgtattag taattataac agatgtataa   1246200
tagaaaagca atgatagata ttatcaatta agcgaattta tatctaaaag ggatattaaa   1246260
gaaaggagat atgcttatga agatttacaa aaaactattt gcttatgtcc aagataagaa   1246320
atatcttggg gttttggcca taattttttc tgctatatct gctgcactta cagtatatgg   1246380
atattattta atctacaaat ttctagataa gttaataatt aattcaaact tatccggtgc   1246440
agagagtata gcattaaaat ctgttattac actaacaagt ggagcgatat tttattttgt   1246500
ctcaggaatg ttttcacata tcttgggatt caggcttgaa acaaatttaa gaaaaagggg   1246560
aatcgatggt ctggaaaaag caagttttag gttctttgac ttaaatccat ctggtcaaat   1246620
aagaaagatt atagatgaca atgctgcaca aactcatcag gtggtagcac acatgattcc   1246680
cgatagttct caggcaataa tcacacccgt acttgtactt gcacttggct ttatagtaag   1246740
tataagagtt ggcataattt tgcttgctct tactataatt ggtggcttaa ttttaggggc   1246800
aatgatgggc gagcaagaat ttatgaagat ataccaagaa tccctatcta aactaagtgc   1246860
tgaaactgtt gagtacgtga gaggaatgca agttgtaaaa atatttaaag caaatgtaga   1246920
gtcttttaaa agcttttata aggcgataaa agattactca aagtatgctt atgattattc   1246980
cctatcttgt aaaaggcctt atgttttgta tcaatggtta ttttttggac tgattgcaat   1247040
tttaattatt cctatagttt attttatgac tagcttagct agcgcaaagg tgattttact   1247100
tgagcttatc atgattttat ttttatcagg agttctcttt gtttcattca tgagaatgat   1247160
gtggtactcc atgtatattt ctcaaggaaa ttatgcagta gatactttag aggcgcttta   1247220
cgaagatatg caaaaagaca aattagtgca tggtaatgtc aataatttta aaaactataa   1247280
tatagaattt gagaatgtta gctttgctta taatgataaa gctgtcattg aaaatttatc   1247340
ctttaattta gaagaaggaa agtcctacgc acttgtcggt tcatctggat caggcaaatc   1247400
aacagtagca aaacttatat caggttttta caatgttaat aaaggaagca taaagatagg   1247460
cgggatagca ataagtgaat attctgacga agccttaatt aaagccattt cctttgtttt   1247520
tcaagattca aaattattca agaagagcat ttatgataat gtagcgttag ctaataaaga   1247580
tgcgacgaaa gatgacgtta tgagagcctt aaaattagca ggatgcgatt taatattaga   1247640
caaattccca gaaagagaaa atacaatcat aggctcaaaa ggtgtttatt tatccggtgg   1247700
agaaaaacaa agaattgcaa ttgctagagc aattttaaag gattccaaaa ttattattat   1247760
ggatgaagca tcagcatcta ttgacccaga taacgagttt gaattgcaaa aagcttttaa   1247820
aaatcttatg aaggataaaa cagttatcat gattgcacac aggctatcta caattaaaga   1247880
ccttgatgaa attattgtca tggatagtgg aaaaattata gaaagagggt ctgacaaaga   1247940
attaatgtca aaagatacaa ggtataagag cctgcaagag atgtttaaca gtgcgaatga   1248000
atggagggtt tcaaatgaaa gagttttata aaaaaagatt tgctcttaca gatggaggag   1248060
caagaaattt aagtaaagca acactggctt catttttcgt ttattgtata aacatgcttc   1248120
ctgccatatt acttatgatt tttgctcagg aagttttgga aaatatgggc aaaagcaatg   1248180
gcttttatat agtattctca gttttgattt tgatagcaat gtatattttg ctttctatcg   1248240
aatacgataa attatataac acaacctatc aagaaagtgc agatttaaga ataaggacag   1248300
cggagaattt atcaaaatta cctctatctt acttttctaa acatgacatt tccgacattt   1248360
cacaaacaat catggctgat attgaaggca tagagcatgc aatgagccac tcaataccaa   1248420
aggtgggcgg catggtactg tttttcccat taatatctgt aatgatgcta gcgggcaatg   1248480
tcaagatggg tttagctgta attattccat ctattttaag ctttatattt atacctttat   1248540
ctaaaaaata tcaggttaat ggacagaata gatattatga tgtcttaaga aaaaactcag   1248600
aaagctttca agaaaatatc gaaatgcaaa tggagattaa agcatataat ttatcgaagg   1248660
atattaaaga tgacttatat aaaaaaatgg aagatagtga gaaagtacac ttaaaggcgg   1248720
aagtaactac aattttaact ttgtctatat cttcaatatt tagctttata tctcttgctg   1248780
ttgtgatatt tgtcggcgta aatctaatta ttaataaaga gataaattct ctctacctta   1248840
taggatattt actagctgct atgaagataa aagactcttt agatgcatct aaagagggct   1248900
tgatggaaat attttattta tcgcccaaaa tagaaagatt aaaagaaatt caaaatcaag   1248960
atttacaaga aggcgatgac tatagcttaa aaaaatttga tattgatcta aaagatgttg   1249020
agtttgccta caataaagac gcaaaagttt taaatggtgt aagttttaaa gctaagcagg   1249080
gagaggtcac tgctttggta ggtgcaagtg gctgcggtaa aacaactatc ttgaaactta   1249140
tatcaagact ttatgattat gacaagggac aaatcttaat cgatggcaaa gatataaagg   1249200
aaatatcaac agaatccctt tttgataagg tgtctattgt tttccaagat gtggttctct   1249260
ttaatcaaag cgttatggaa aatattagaa tcggtaagca agatgcaagt gacgaagagg   1249320
ttaaaagagc agcaaaactt gcaaattgca cagattttat agaaaaaatg gataaaggtt   1249380
tcgatacagt tattggtgaa aacggagctg agctatcagg aggagaaaga caaagattat   1249440
caatagccag agccttctta aaagatgcgc cgatattgat cttagatgag ataacagcaa   1249500
gccttgatgt taacaacgag aaaaagattc aagagtcttt aaataattta gttaaagata   1249560
aaactgttgt aatcatttca catagaatga aatccataga aaatgcagac aagatagtag   1249620
ttcttcaaaa cggaagagta gaaagcgaag gtaagcatga agagctttta caaaaatcaa   1249680
aaatttacaa aaatttaata gaaaagacaa aaatggcaga agaatttatt tattaggagg   1249740
actacaatgg ataataaaaa attaaaagta aaagatttag taagcatcgg tgtttttggc   1249800
gtaatttatt ttgccttcat gtttggagtt ggtatgatgg gcttgattcc aatattgttc   1249860
ttaatatacc cgacagtatt agccatagtt gcaggaactg ttgttatgtt atttatggct   1249920
aaggttcaaa agccatgggc actatttata tttggtatga tatcaccact tgtgatgttt   1249980
gcagctggtc atacctacgt agttgtggtt ttatcactta tagtaatgat aatagcagaa   1250040
ttaattagaa agattggtaa ttataattca tttaaataca atatgctttc ttatgcaatc   1250100
ttcagcacat ggatatgtag ctctttaatg caaatgcttt tagcaaaaga aaaatatatg   1250160
gagtggtctt tgatgactat gggaaaagat tatgttgatg tattagaaaa gttaataact   1250220
tatcctcaca tggctttagt agccttaggt gctttcttag gaggaattct tggagcatat   1250280
ataggcaagg ctctattgaa aaaacacttt tcaaatggat tatattgtgt gggatacttt   1250340
actccttgcc taattttatg gtgctatctg aattaaaccc tatagttaag atgtttttga   1250400
gtatacctat tgttattaga atgtttattt taccatttat ggcagcaagc tttatgataa   1250460
agacctcgga tgtaggcgca ataatttcat cgatggataa gcttaagatt tcaaagaatg   1250520
tatccatacc tattgcggtt atgtttagat tcttcccatc ttttaaggag gagaagaaaa   1250580
acatcaaaat ggctatgaga gtaagaggga taaattttaa aaacccagtc aaatatcttg   1250640
aatatgtttc tgtgccacta ctcattatat catctaatat atcagatgac attgcaaaag   1250700
cggcagaaac aaaggcaata gaaaatccaa ttgccaagac cagatacatt cgcgtaaaga   1250760
tacagctaat tgattttgtt tatgttttag cggttgctgg acttattgtg ggaggcttaa   1250820
tatggttgaa ataaaaaatt taagtcttga ttatggtgaa gagcatatat tagatgatat   1250880
atcactatcc atagccgagg gagagtgcgt gctatttaca ggaaaaagtg gaaatggtaa   1250940
gtcatcttta ataaattcaa tcaatggact agctgtaagg tatgataacg caaagacaaa   1251000
gggcgaaata attattgatg gtaagaatat aaaaaatttg gaactttatc aaatctcaat   1251060
gcttgtttca actgtttttc aaaatcctaa gacatatttt tttaatgtca atacgacatt   1251120
agaattatta ttttatttgg aaaatatcgg tcttgcaaga gaagagatgg acaggcgttt   1251180
gaaggatata cttgagatat tcccgataaa aaatcttttg aacagaaata tatttaatct   1251240
atccggcggt gaaaaacaaa ttctttgcat tgcagcttct tatatagcag gtacaaagat   1251300
tatagttatg gatgagcctt catcgaattt agatattaaa agcataagtg ttttggcaaa   1251360
gatgctaaag atattaaaag agaaaggcat aagcataatt gttgcagagc atagaattta   1251420
ttatttgatg gacatagttg accgtgtatt tttaatagat aaaggaaagc ttaaaaaaac   1251480
ttatactaga agtgaatttt taaagctaga taaaaatgaa ttaaatgctt taagtttaag   1251540
agataaagaa ttaagtaaat taaaagttcc ttatttaaaa gaaggtggag agtatcagat   1251600
aaaaaatctt agttacaaat ttactgatga tgagtgttta agcttaaaag atatttcgtt   1251660
caagcttggg aaaatttatg gcataatagg atccaacgga cgaggaaaat caacgctttt   1251720
aagatgttta ataggtcttg agaaaaaatc aaaagaagaa atttatttta agggagagaa   1251780
gctatctaaa aaagaaagac tcaaaaactc ttcacttgtt atgcaagatg taaatcatca   1251840
attattcaca gatgaagtat tcaacgagct tagattagga gtaaagaatt ttgatgaaga   1251900
aaaggcgaaa atcattttaa accccaatta ttcaccccaa atctaaaaac catccagaat   1251960
ccttgcctta gcttagatcc tggatggttt cttttttcac ccaatgggtg ttttttacta   1252020
gacaaaaaag agtttcccct ttatggtata agtgtagaaa aaaacacaaa aagaaaggaa   1252080
actcacatga acagtttacc aaatcatcac ttccaaaaca agtcttttta ccaactatct   1252140
ttcgatggag gtcatttaac ccagtatggt ggtcttatct tttttcagga acttttttcc   1252200
cagttgaaac taaaagagcg gatttctaag tatttagtaa cgaatgacca acgccgctac   1252260
tgtcgttatt cggattcaga tatccttgtc cagttcctct ttcaactgtt aacaggttat   1252320
ggaacggact atgcttgtaa agaattgtca gctgatgcct actttccaaa attgttggaa   1252380
ggagggcagc ttgcttcaca gccaacctta tcccgttttc tttccagaac tgacgaggaa   1252440
acagtccata gtttgcgatg cctcaacctt gaattggtcg aattcttttt acagtttcac   1252500
cagctaaacc aactcattgt agatatcgat tctacccatt tcacaactta tggcaagcaa   1252560
gaaggtgttg cttataacgc ccactatcgt gctcatggct atcatcctct ttatgctttc   1252620
gaggggaaga caggttattg tttcaatgcc cagcttcgtc ctggtaatcg ttattgttct   1252680
gaagaggcag acagctttat cacacctgtt ttagaacggt ttaatcaact tctctttcga   1252740
atggatagtg gctttgcgac cccaaaatta tacgatttaa ttgaaaaaac agggcaatac   1252800
tacctcataa aactcaagaa aaatactgtt ctgagccgtc ttggagacct ttccctccct   1252860
tgcccacagg atgaggactt aaccatcttg ccccactccg cctactcaga aactctctat   1252920
caagcaggat cttggtcgca caagcgtcgt gtctgccagt tctctgaacg aaaagaagga   1252980
aacttgttct acgatgttat ttctctcgtt acaaatatga cgagtggaac aagccaagac   1253040
cagtttcagc tttatcgtgg acgtggtcaa gccgagaatt tcatcaagga gatgaaggag   1253100
ggattttttg gcgataaaac ggatagttca accttaatca aaaacgaagt tcgtatgatg   1253160
atgagctgta tcgcctacaa tctctatctt tttctcaaac atctagctgg aggtgacttc   1253220
caaactttaa caatcaaacg cttccgccat ctttttcttc acgtggtggg aaaatgtgtt   1253280
cgaacaggac gcaagcagct cctcaaattg tctagtctct atgcctattc cgaattgttt   1253340
tcagcacttt attctaggat tagaaaagtc aacctgaatc ttcctgttcc ttatgaacca   1253400
cctagaagaa aagcgtcgtt aatgatgcat taaagaacag tcgagatgaa aaaatcgtgt   1253460
gacgaaccaa gggaggagtc tgcccttttg aggaaatcta gcgaggaaaa acgatactgg   1253520
aacagcagaa agtaaaactg acctcatgag gaggaagaaa gtggctcatg aggtcagggg   1253580
ttttgtaagt tacatctagt tgagagaggt atgaatgatt tgggttaaaa gatttatgcc   1253640
tggacgaatt tattgaaagg catccgatga gtttatcagg agggcaaaag caaaggcttg   1253700
caatagcatc tgttatgtgc aagaattctc catttgtctt ttttgacgaa ccttcaagtg   1253760
gtatggatta ttccaatatg ataaaaatat ctgaactgat taataagtat aaaaccatgg   1253820
ataaaataat ttttattgtt tcccatgata tagaattttt aaatgaagtg gcagatgaaa   1253880
tttttgaatt gtaaaataga gtctgttaaa catgtctata gaactagtaa attgtctaaa   1253940
aatttaaaag atactaacac atattgatat ttattagaaa attaacttca ggatttttac   1254000
agtatttata aactttataa tatgtattta tagtattaat aatttccata tctttaggga   1254060
aattatttat ttacttacca taattaaaga gatgagagat aaatatcggc agtcttcgga   1254120
ctgcctttat ttttttactt aatttaatgc agtaaatcat acgattgaaa ggaatctgcg   1254180
ttatatgcta taattaggta gttaatctat acatttagaa aggtaaaata tagaattgga   1254240
gaataatatg ggattttcat ataataaatt gtaaccgtcc aataacgaag tctattgaaa   1254300
aatctccaga ctagagaact cacggatagt tcctaatctg gagatttctt atttgcactt   1254360
ttcttgtaca actttagtcc acggtaaata ggcctctaaa acctctttgt ttacgagagt   1254420
ttcctcgttt ggaagacatt ctagaagata ggatagatat ttctcgctat ttataatgga   1254480
ttgaaataag atatgaacaa atcgattagg aaaggaaaat tgatttatag aaatgtttta   1254540
gcagtcgatg cgtactgtta tagattcaac gcactataat tgatgacgtt tagctgtttc   1254600
caacaagctc ataacaatag ctcttgcttt agctccttca aaactttgag aaaataacca   1254660
ccctcgcttt tttaaactga gctcaggcta aaagagtcca ctggactctt ttactccgtc   1254720
ccataaccaa tgatttaatg gcgcgttcag ctagattatt ggaaaggacc agatgtccgt   1254780
ctttcaaaat agtcttaaag gtttcttcat acttgaggct gtattcaatt gcccttccta   1254840
gttttgaacc tgctaaaact gactgacggc ggcaccaagc aaagaagtct tccattaggg   1254900
gctggagatg ttcttgacgt ttctgtagtc gttcatcagc tggcaaagcc tcccagtctc   1254960
tttccaagga aaataactga tcacaataag ctaaaccttt agctcctaag gatgatttat   1255020
ctgcttgctt ggggggcact tcaaaaaact tccttctcac atgcgcccaa catccaacaa   1255080
gtgcagcttc ttccagttga cgataagctt ctagctgttc gcagtttacc aagcttagcg   1255140
tcgccttact cctaaacctt ggactgctat cgcataggca gaactagagg actaaagtcc   1255200
taagttactg ccgcaacatg tcacaatgaa catagccaga ataatctcct aggaattctt   1255260
gtactactaa accactccga cgctgatcat ggtggtacag cgtgattgct tgattctcag   1255320
ctttcccaga caaaaaagtc caatagtaag gcaactgact atcactctct agaacccgat   1255380
aagaggtttc atccgcatga agaagagctt gttctaacaa cttttctcgt aaaagattat   1255440
aaaggggctc caaatagtat tgactcgcct tgatatgcca attagcaatt tccttacgtg   1255500
tgattggtaa acccatctta gcccaatctt cttcttggcg ataattgggt accttcagat   1255560
taaacttctg atggatggtg tgagcgataa tagaagctga gccaaggcta tgcgccaaag   1255620
gggctttagg aataggagct ttcacgattt tatcactcgg atttttatca ctgcatgctt   1255680
ggcacttata agcgtgttgg atatgatcta ttcgttttaa ttgcgcagga ataaagacta   1255740
attcttgtcg ttgaagggtt gctccaatct cttttagatc tccctgacaa tcagggcaaa   1255800
tgctctcttc tacttgatga tgaacttctt ctgaatcaaa ttgggcaaga agagcttgac   1255860
gtttcccttt agctttctta cgtttatagg tgatttcttc tctttcaact gggtaagtca   1255920
gagtcttctt ccatattttg ttcctcttca aaaagactga gttgtccaga tgggcaaaca   1255980
cttttctcag aggattttcc atagagcttt tgcgttagat aagccacttg ttcacgaaga   1256040
agggcaagtt cattggtgag actatcaatt gtagcactct gttgttgaat gattttcaat   1256100
cttcttccat gggcttcctc tccttatttc ctaactttat tataactaaa aagaaagtcc   1256160
tcatttcaat agaaatcacg actttctgat aaatttattt ttggagtgat agaaaagccc   1256220
ttcataagcc aatctacttg ttcaggtgtg agagctttga catccttttc tgtactgggc   1256280
caagtcagtt ttccgttctc aaagcgttta tatagtagcc aaaatccttg accatcccag   1256340
taaagggctt taaagcggtc tttacgtcca ccacaaaaga gaaaaacttg accggagaaa   1256400
ggatctaatt caaagtgggt tttaaccaga taagccaatg aatcaatgcc ttgcctcata   1256460
tccgttttcc cacatacgag atagacctgc cctaggctag atagatgaat tgtcatagag   1256520
caacacttta tccaaaagct gttctaccat ttcgagattg agagattgaa aaaaacttac   1256580
ttcaagcttg ccaatacgaa ttttaagcag aatatcattt ctctttttag aatcaaaacg   1256640
acgagattgt ggaatctcta caggaacaat aggttgtggc attaaaatat cctccaatag   1256700
ttttacttta ctaatagtat acaggaggaa ctccatgaat gatagatacc ttgttatgac   1256760
gcgattacta tattagaaag ttggctctct aattaaatta attcggttct ataatatttg   1256820
tagtgggtaa atccactata gatattatgg agcctatttt attgtagaaa aaaagtccca   1256880
tatgacctat aatgaaaagc gacaaaacaa ctcattagaa agaatcatat ggaacaatta   1256940
cattttatca caaaattact agacattaaa gaccctaata tccagatttt agacatcatc   1257000
aataaggata cacacaagga aatcatcgcc aaactggact acgacgcccc atcttgccct   1257060
gagtgcggaa accaattgaa gaaatatgac tttcaaaaac cttctaaaat tccttatctt   1257120
gaaacgactg gtatgcctac tagaattctc cttagaaagc gtcgattcaa gtgctatcac   1257180
tgttcaaaaa tgatggtcgc tgaaacttct atcgtcaaga agaatcacca aatccctcgt   1257240
atcatcaacc aaaaaattgc tcaaaagtta attgaaaaga tttctatgac tgatattgcc   1257300
catcagcttt ccatctcaac ttcaactgtt attcgtaagc tcaatgactt tcactttaaa   1257360
catgattttt cttgtcttcc tgagattatg tcttgggatg agtatgcttt tacaaaggga   1257420
aagatgagct tcattgcgca agattttaac aatctcaata tcatcactgt tcttgaggga   1257480
agaacacaag ctatcattcg aaatcacttt cttaaatatg atagagccgt ccgatgtcgc   1257540
gtcaaaatta ttactatgga tatgtttagt ccttactatg acttagctag acaacttttc   1257600
ccatgtgcta aaatcgtgtt ggatcgcttt cacattgtac aacatcttag ccgtgctatg   1257660
agtcgtgtgc gtgttcaaat catgaatcaa ttggatcgaa agtctcatga atacaaggct   1257720
atcaagcgct actggaagct catacaacag gatagtcgta aactcagcga taaacatttt   1257780
tatcgcccta cttttcgtat gcatttaacc aataaagaga ttttaaacaa gcttttgagc   1257840
tattcacaag acttgaaaca tcactatcag ctctatcaac tcttgctgtt tcactttcag   1257900
aataaggaac cggagaaatt tttcggactc attgaggaca atctaaagca ggttcatcct   1257960
ctttttcaga ctgtctttaa aacctttcta aaggacaaag agaaaatcgt caacgccctt   1258020
caactacact attctaacgc caaattggaa gcgaccaata atctcatcaa acttatcaag   1258080
cgcaatgcct ttggttttcg gaactttgaa aacttcaaaa aacggatttt tatcgctctg   1258140
aatatcaaaa aagaaaggac aaaatttgtc ctttctcgag cttagctgac ttcaacccac   1258200
tacagttgac aaagagccat taattctcat tatatatatc aaaagaccgc agcttgaaaa   1258260
ctacggtcta attttttgtc caaatgtaaa ccacttggaa ctattattca atttattctt   1258320
tttagcaaat gttcccgttt taatcccagt tacagttttt aatcctctgt aaccgttgat   1258380
tttacaaagc ttttaatttt tttgcgatta ttcccactca actgttgcag gtggtttact   1258440
tgtaatatcg tagacgatac ggttaacatg atccacttca tttacgatac gtactgagat   1258500
tttttgaagt acttcccatg gaattttggc aaaatcagca gtcataccat cgatagaagt   1258560
gatagcacgg attgcaatcg tgtagtcata cgtacgaccg tcacccataa caccgactga   1258620
acgaacgcct gtgttaacag tgaagtattg ccaaatatcg cggtcaagtc cagctttagc   1258680
gatttcttca cgaagaatag cgtctgattc acgaacggtt tcaagtttct cttcagtgat   1258740
ttcacccatg acacggatag caagtcctgg tcctgggaat ggttggcgcc atacgatatg   1258800
gtctggcata ccaagctctg taccaagagc acgaacttca tccttgtaaa gagtattgag   1258860
tggttcaatc aattcaaact gcatatcttc tggaagacca cccacgttgt ggtgtgactt   1258920
gatagtttga gctgtatccg taccagactc gataacatct gtatataaag taccttgagc   1258980
aaggaatttc acatctttga gcttgcttgc ttcgtcatcg aatacataga caaactcgtt   1259040
accgatgatt ttacgttttt gttcagggtc agaaacgcca gcaagtttgt caaggaaacg   1259100
tttagcagcg tctgctttga cgatattcaa accaaactta ccaccgagca tgtccataac   1259160
ttgatcagct tcgcctttac gaagaagacc gtggtctacg aagatacaga tcaattgatc   1259220
gccaatcgct ttttggagaa gaaccccaac gacagatgag tcaacaccac ctgatagacc   1259280
aagaaggaca cgtttatcac cgacggtttc acgaattttt ttgatctgca tgtcaatgaa   1259340
attatccatt gaccagtcac ctttagcctt acaaatgtta agggcaaagt tacgaaggat   1259400
atcatttccg tatacagaat gacgaacttc tgggtggaat tggataccgt aaatgtgttt   1259460
atctgggttt tcgatggctg cgtatgggca gtcagctgat gtacctgtac gaacaaagtc   1259520
agcaggaatc tcagtaaccg catcaccatg gctcatcaaa acagtctgtt catcaggtgt   1259580
tgattcaaaa agcgctgatg gtgtgtgagt tagggttgat tgaccgtatt cacgatttcc   1259640
agcatcacct gcaggaacaa cttttcctcc aagtttatgg gtcaataact gcataccata   1259700
acagattccc aaaattggaa ttccgagttc gaagatttct gggtcaatat caaatgaacc   1259760
atcttcatat acagaatttg gaccacctga tagaataatt cctacaggat tgacttcacg   1259820
aacttcagca gctgaaattt tatggctttt tagttctgaa aaaacaccaa tctcacggat   1259880
acggcgtgaa atcagctggt tgtactggct accatagtcc aatacgatga ttttttctac   1259940
atcttgcaaa tcagttgaaa tgttgctcat ctttttcctt tctcaaaaga aatatctttt   1260000
ctcaatattc tatcacaaat aagggcgaat taccaactaa acaaggcgaa gtttgacttt   1260060
ttctagttta ttggggtaca atagagaaaa gatagaaatg aagtgaaaaa tatgctacct   1260120
gcttatataa aaatccatga tcagataaaa aaggatattg acgagtaccg ttgggctatt   1260180
ggtgagaggc ttcccagtga aagagattta gctgagcagt ttgcggtcag tcgcatgacc   1260240
ctccgccaag ccgtatctct attagtcgaa gaaggcgtct tagagcgccg tgtaggaagc   1260300
ggcacctttg tttccagtac tcgagtacaa gaaaagatgc gagggacaac cagttttact   1260360
gaaattgtca aatcccaagg taaagttccc tctagccagc tcatttccta caaaaaaacc   1260420
attcccaatg agcaagaagt tgccaagcta ggaatttttc caacggacaa tattatccga   1260480
atggagcggg tccgctatgc cgaccaagtt cccctagttt atgaagttgc ttctattcct   1260540
gaaaaattca ttaaggactt taaaaaagaa gaaatcacca gtcatttctt ccaaaccttg   1260600
caaaaacatg gctatcgtat cggcaaatct caacagacca tctatgctcg ccttgctaaa   1260660
gaaaagattg cccactattt ggaagttgaa aaaggacatg ctattcttgg attgacccag   1260720
gtttcctacc tagaagatgg tactgctttt gaatacgtaa aaagtcaata tgtaggcgaa   1260780
cgctttgaat tttatcttga aaataattag attaccacgc aaaaactctc tgtcacggac   1260840
aaagagtctt ttttattttt ctaagaataa atctttcaaa gaaatcaaag ttacagcaaa   1260900
caatatcatt gccataccaa gaaaatcaat gggataaaat tgttcattca ttattaagaa   1260960
ggcaaagaaa atcgccgata ttggctcaat tgaagccaac aagcttgact tgaccggtcc   1261020
tatcagactg gctcctttaa ggaaagctgt ataggcaaag acagtcccga taaggataat   1261080
gcctgcaaac gcaaggagaa aatcaagact agtcgggata tcggcctgta gaacccctgt   1261140
aaaaggaagg gcgaccaaac ctgctatgac cattcccaca ccaatgacca agctgctccc   1261200
ccacttttta atcaaggcta tgggtaaaat gatatacaga gcataagtca aggcagaaaa   1261260
gagaccccag aacagaccag caggtgtcat ggataactgg tccaactgcc catgtgttgc   1261320
gatcaggaag gttcctccga tggcgaatat gatggaaact atctctccca gtgtcggtgc   1261380
caccctatcc ttgatacagc tataaattaa aattccgaca ggacaaacat actgaagcac   1261440
cgtcgctgtt cccgcattgg tctcctgaat agcagacaga taggcgaatt ggttgagaaa   1261500
aagaccaatc agagcaaaaa taagaagaga cagcaaactc tttctatcct ttaaaaagac   1261560
cagtatttta tcctttgcag tagcataagc caagagcatg agaattccac cagcgattaa   1261620
aagacgcaag ttagtcaaga ccagagccga aattccgtgt gccattaggt attggccact   1261680
cgttcctgac aacccccaag caataccagc cacaactgtt agtaaagtcc cttttaaact   1261740
atttgacatg tctctcctta ctcttctttg cgaatcaagt tcatcacttg attgcggtct   1261800
aatatccatt gagctctctc gtccttttca taggtacgat tcgataggaa aatagtggct   1261860
tcttgcttct gacgattcca catgataaag gtacctgtat agcccgtatg gtctagccaa   1261920
tctccttcca aattccatgc taaagaacgt tccttgtcat ccaaaggaga aaaattttga   1261980
tttaagtctc ttgcaaaatc atctgctaaa tagtgttcta aaaagatttg taaatccttt   1262040
atagtcgaaa ataaaccagc actcccagca tgtctaccca ggagacgagc cttgggatca   1262100
tgcactatgc ctgcctctac acctctaact gttggaacag caagctcaac tggcccaaac   1262160
ttagtttccg tcattcccca aggtttccag acttgatcct ttaaaatcac atccaaatct   1262220
tgattaaaaa ttctttccaa aataaagccc aacagcaaaa aatggacatc cgaataaaga   1262280
aaggctggct gacttcgtct gttgagatga aacatcgctt cctttaattc aggggctgtt   1262340
aaaagatcac gattaggaat aaaaggatca aggtctgttg catgagtcaa gagctggcga   1262400
atagtgatgt ctggataatc actctcaggt aaaaaatcta ttaccagtct atcaatatct   1262460
aattgaccta tttcccacaa gaaggtacaa actgtgccaa ccccaacaac cttgctgaca   1262520
ctagctaggt cataaactag tcctgcctca gtctgcaagc catgctctgg gtcactctgg   1262580
cctaaataga actctgtcca ttgattgtcc ttaaaatacg caaaagaggc tccgggataa   1262640
atccctgcct cgatttgttc ttctattttt ttaataatct tggtccactt catacttctt   1262700
caaaccacaa ttcaacatta tttctatctt taccaaggaa gaatttttca gacttaggaa   1262760
taaaatattc agtagactca aacttctggc gaagacttgc tatgtctaat tcattgacca   1262820
agaacttgag catagataag tcccaggtaa ccgtattgtc cacagtcaaa tcctgcccct   1262880
gagctggaat aaaatcaagg gatgccccaa tttcagatga ttccaagaaa ctttcgatat   1262940
cagttgggag atgtaattcc atagaaatct caaatttact taaagaaatt gatgccaaat   1263000
ctgtttgaaa ttcaggcttt tctcctactt ctactagact tgctatgtca tcttccgcat   1263060
gaatcaaaat caaatcatct tctggtgaga aaatttcaaa agcgtagcca ttttgacctt   1263120
tatataatcg atgaatcgaa tctgttttag ataagattcc ttcaatttct aagggatttt   1263180
ccaccttgac aatcaatcta gctagttttt ttcttccctc taccttacga gtacgcatac   1263240
tgggagcttc ttctaaaacc agcttttcaa gacccgtttg gtcacctagt gacagaaagg   1263300
ccgattcttc taacaaggcc ttcattccaa gggtttcaat ataaaatgtt tcatttaatt   1263360
ttctattatt agcttttaaa gtaggaataa tccgtacaat ctgatttaca ttcataaatt   1263420
cctccgtcac tttttatttt aaaggatttt agaatttttt acaagatatt atgctcaaat   1263480
ttaacattat ttagctattt agtaaagata gtctttcaag gattttgaca aagcctgata   1263540
accagcaata ctgaggtgca gtccatcagt tgtatattct tttttgagtt ggcctgcttg   1263600
gtctgtcaaa caatcaaata ctggcacaaa ttccacctgc atataggcag atgcaagctc   1263660
ttgataggct tgattccagt tctgaatttt ttcattcgag cggatataga ctgcctgctg   1263720
gtactcctct ctctcattga caggcaaaat ggaaagcaat ttaatctctg tcaatggata   1263780
atcgcgagca acggattgaa tgatagcttc gagattattg agagcctcat tcacaggaac   1263840
atcctttccg atatcatttg tcccaatcag aagaaaaatt ttatctactg ctccaccata   1263900
tagatgagca tcaaggttct ctagtaacag tcctgtctga tagccacgaa ttcctcgatt   1263960
gacaatcgtc tttgaagtcc caaatagctc ctgtagagga taatactcga caatggaatc   1264020
cccaataaaa agaatgtttg gttctacaac agaaatgtga tttaggtgac gatacttagt   1264080
ttgaattttt tcttgttcct ttaggagcca attttctaat aactgtactg ccacttcatt   1264140
ctcctttttc taaccagttt tccaagactt gataaactcc tccttggctg ttggctggtg   1264200
ctagagcagt cgccacagct ttggctttct catcagcatt ttccatcgca taggcaattc   1264260
cagccatttc aagcatttca acatcatttt cactatcacc aaaagccatg atttcttggg   1264320
atttcaagtc ccagcgcttg agtaattcct ccaagcccca tgctttatga atcccagctt   1264380
ggaggatatc aatgcaacca tagccactgg atacagctcg gacacggcca tcaaagagag   1264440
cattgatttc ttccaaaacc gaactcaaac gttcctcacc aacaaccatg ctcatcttga   1264500
gcacaccacc aaagaggtca gatgttaatt catccacaaa ttgcatccgt tggtagaatt   1264560
tttcaatcat ttctggagtc ataaaacttt caagatctgt aaaaatcgta ccttccttga   1264620
caaaatcacc cttcatcccc gttacaacaa actggtcctg acacgctcga cccttgaaat   1264680
gagtcaaagc cttgttgaca atggcgtcat cccatgtctg agcctgaatc aattcattgt   1264740
tttcaaaaat acgagcgcca ttagcaacaa ccagaaccac tcgatccacc aagggactca   1264800
gtagttgtct catgcggtga atttcattgc ccgtcgcaat gacaaaacga atgccccttt   1264860
gatccaactg atctaaaatc ttttccaatc gtgggagatc aagctgacct ctagcatcca   1264920
gcaaggtccc atccatatct gtcgcaatta ccttaatcat catttacttt cctctggatt   1264980
caagctaata ccacttcaat cccacatgtt cattcatttc tttataggct gtatcaattc   1265040
gttccttagt cgcttcatct aactggtcac gatgactgcc atcctctata aaatcttcca   1265100
aaatataagt ttggtaatga tacaagggat atccttctgg tgaaaaggtt ccctttggtg   1265160
ttcgattgac ccaagtagga tgagctttag ctgttccgat agttgttttt ccatccttct   1265220
tcttgatggt gacatccatg agaacaccac gttcagtcca cttagcattc tcttcatctc   1265280
ccatagattc aattcgttga ttggaaatga agttccccat ttaatagata atgagtttct   1265340
tatctccatc tttttcaacc gtttcagatg gttcaacaac gtgaggatgc cctccaaaga   1265400
taatatccgc tcccaaatcg atcatcttgt gataaagagc tttttgttct tcagttggtt   1265460
ccaatcgata ctcaacaccc atctgaagca tgataatggt gatatctgct tccttctctg   1265520
cccgttcaat ttcaaccttc atcttatctt cgtttaaatc tgaaagataa cgattatagt   1265580
cttcctgaga aatatactgc tcaattccat tgaaaccata ggaataggct aacaatgcaa   1265640
ccttgatacc attcacttcc ttaatgacca gcggagcctg atcacgtggt tcgtgcgtat   1265700
aaactccgat tggagtgatt ccagctttct caataatatc ggccgttgaa ataactccct   1265760
caatttgcga atccaaaata tgattatgag ctaaatccag cacatgataa cctgcctcct   1265820
taatagcatc cataacttca acaggagcat taaagagaag ataacccgct aaataatgat   1265880
ccttattaat ggttccttca aaatcaccaa tagctaaatc tgctgcttag tccccttgct   1265940
tgagccaagg agtcacatac tcaaaatttt catgaaagtc ataggtaccg tcttcttttt   1266000
tagctgaaaa gaaaagtcca tcgtggtaga gcaaatcccc gtgggccata attctggcag   1266060
ttttttcctc ttcctactcc tgagactttt gcttagtccc ctcttgagaa atagtatctc   1266120
gtttttgact agtcaaggga ttccttggaa gctttcaaac aacaagacca agcccattga   1266180
taaaccaact gctagcaaga gtatcgccac aaatccctta ttgctccact tgcgataact   1266240
cctaaaaagt ttaccaagcc cttcataaaa cgaaaagcta aaccaccctg atttcgattt   1266300
tgtcttcttt gtatcttcgt tctccctact ttcttatgca agccttttct ttttattata   1266360
tcacagataa gtatttcttt cacaattgaa ttgaacttcc tatctatttt ctataaatcc   1266420
taaatgccat aatgctttca attcttgtca ttttgtgata tcatgtagag gtaatgaaag   1266480
aaaatgaact aatccacagt ggcttattcc aagtatacca cttgggcttt ggcagtagct   1266540
aactgcacta aacataatat aaggagagaa aatgtctgca atagaacgta ttacaaaagc   1266600
tgctcactta attgatatga acgatattat ccgtgaaggg aatcctactc tacgcgcgat   1266660
tgctgaggaa gtcactttcc ccctatctga ccaggaaatc atcctaggcg aaaagatgat   1266720
gcaattcctt aaacattccc aagatcctgt catggctgaa aaaatgggac tccgcggtgg   1266780
tgttggactg gctgctcccc agttagatat ctcaaaacgc attatcgctg ttttggtacc   1266840
taatattgtt gaagaaggcg aaactccaca ggaagcctac gatttggaag ccattatgta   1266900
caatccaaaa atcgtctctc actctgttca agatgctgct cttggcgaag gagaaggttg   1266960
cctgtctgtt gaccgtaacg tgcctggcta tgttgttcgc catgcccgcg ttactgttga   1267020
ctactttgac aaagatggag aaaaacaccg tatcaaactc aaaggctaca actccattgt   1267080
tgttcagcat gaaattgacc acattaacgg tatcatgttt tacgatcgca tcaatgaaaa   1267140
agacccattt gcagttaaag atggtttact gattcttgaa taaagaaaat cccgttgcaa   1267200
gacggggttt tgtgttataa tagaggcatg aaaacaaatg atattgtcta tggtgtccac   1267260
gccgttaccg aagccctcct tgcaaataca ggaaacaaac tctacctcca agaagatctc   1267320
cgaggtaaga atgttgagaa agtcaaggaa ctagctacag aaaagaaggt gtccatttct   1267380
tggacatcaa aaaaatctct ctctgagatt actgaaggtg ctgttcatca aggttttgtt   1267440
ctacgagtgt ctgaatttgc ctatagcgag ctagattaca tccttgcaaa aacacgccaa   1267500
gaagaaaatc cacttctatt gattctagat ggtctaaccg atccccataa tctgggttct   1267560
atcttgcgaa cagccgatgc gaccaatgtt tcaggtgtca tcattcccaa gcaccgtact   1267620
gtcggagtaa ctcctgtcgt tgccaaaaca gccacaggtg ctattgaaca cgttccaatt   1267680
gcccgagtga ccaacctcag tcaaacctta ggataaactt aaggatgaag gtttctggac   1267740
ctttggaacg gatatgaacg gtactccttg ccacaagtgg aatacaaaag ggaaaatcgc   1267800
cctcatcatt ggaaatgaag gaaaaggtat ctctagcaac atcaaaaaac aggtcgatga   1267860
aatgattacc attccgatga atggacatgt tcaaagcctt aatgccagtg ttgctgcggc   1267920
cattctcatg tacgaagttt tccgaaatag actataaaaa agtttccagt catctgattg   1267980
gaaacttttt tatgattaac tatgttctgt aatgaattta taggcttctt gaccagcgat   1268040
agctccatct ccaaccgctg ttgttacttg gcgaaggtct ttcaagcgaa catctccaac   1268100
tgcaaagata ccgtcgactg cagttttcat gtggttatct gtcacaatcc atcctgcctg   1268160
atcttggata ttcaattctt taacaaaatc gctaagaggg tccaaaccaa catagataaa   1268220
gacaccaccg aaggcttgtt ctgtcacttg acctgttttc acattttcaa atacgactga   1268280
ttctactcgg ttttcaccct tgatttccct tactacagaa tcccagataa agctgatttt   1268340
ttcattcgca aaggcgcgat cttgtaaaac cttttgggca cgaagttggt cacgacggtg   1268400
aacaatggta acagtcttag caaaacgagt caagaagagg gcttcttcaa cagctgaatc   1268460
tccaccacca actaccaata aatcttggtc acggaagaaa gcaccatcac acacagcaca   1268520
gtaagaaaca ccacgactgt tcagttcttc ttctccaggc actcccaaag gacggtgttt   1268580
agaaccagtt gctacgataa ctgtacgtgt ttcatatgtt tggtcatcag tcatcacttt   1268640
cttaaaatca ccatggtctt cgacattttc aacataacca taaatgtgct caacaccaag   1268700
attttcaagt ggttcaaaca tcttttcagc caattcaggt ccactaatat tagcgtatcc   1268760
tgggtaattt tcgatatcag atgtattatt catctgacca cctggcagac caccttcaat   1268820
caaagctact tttagattgc ttcgagcagc atacaaggcc gcagtcatcc ctgcaggtcc   1268880
agcaccgata ataatagtat cgtacatata gattccttct ttcttgttgt aactatcttt   1268940
attctaactc tttcttgtca atcacgcaag gattatgcct tgaaaacaag aattaaactc   1269000
ataaccgcaa aggataatac tgggacaacc aagactccaa tcataatcat atcatagaga   1269060
tgggcttggc gagccctggc tgtcttatca actcccgaca tggctctcag accaatccaa   1269120
atccctaaaa aaatcagaac aaggatggtg gtcaagatca aactctcgaa atataaagaa   1269180
aatagttgca gtagcatgat ttctctcatt tctatctttt ttaaagagta aactcagcta   1269240
gtccaactaa ctgagttttc ctttatctat tatatcaaat ataagtccgt ttgtaactag   1269300
cgaagaattc ttttgtccgc tcttctttag gggtgtggat aatctcatcc ggagttccag   1269360
actcgatgat tttcccctta tctaagaaga gaattttatc cgcaacttgg gctacaaagg   1269420
acatgtcatg actgaccaaa atcatggtct gacctgactt agcagcatct gcaatagact   1269480
tttctacttc accgaccaat tctgggtcaa gggctgaagt tggttcgtct aagagcaaaa   1269540
catctggttt catagcaagc gcacgcgcta gggcaacccg ttgcttctgt ccacctgata   1269600
aatggcgagg ataatggttt tcacggtccg aaagcccaac cttagccaac tcttccttgg   1269660
caatcttagt cgcttcttgg tcagataatt tcttgacaac aaccaagcct tctttcacat   1269720
tatcaagtgc tgttcggcgt tcaaacaaat taaactgttg gaaaaccata gacaacttac   1269780
gacgtagggc aaggatttct tcttgagtga ttttagaaaa atcaactgaa aaaccatcaa   1269840
tctgaataga gccactgtca ggtgtttcaa gataattgag actgcgaaga aaggttgatt   1269900
ttccagctcc tgaagaacca atcaaggcta caacttcccc tttttgaata tccaagtcca   1269960
gatgatccaa gacagtctgt cctgaaaagg atttgcttaa attcgaaatc ttaatcatta   1270020
acgaaggtct cctttcacat ctgtttgcac tgtatcaggt gcagaaatag ccatttttct   1270080
ctcgatgaaa cgaccgaggc tttcaattcc gatattgact acccaataaa caagggcaac   1270140
ggagatgaag cgttcaaaat agcgataatc agctccacct agaatctgag cttgggcaaa   1270200
gacttccaca acacccgcac taaaagctag agatgttccc ttggtcaaac cgatgaggga   1270260
attaatcaag gttggagtag ctaccaccgc tgcattagga ataatcactc gtcgataaac   1270320
ttgcgctcgg gtcataccca gactgcgtgc cgcctcaatc tcaccaggat taactgagag   1270380
aatggctgca cgaatggttt cactagcata agctgcctca ttaaaggcaa aggcgacaat   1270440
cgcaaaagct gcagctggaa tcgcattgat attgagacca gttccccatt gctgattgag   1270500
ggctttcaaa gccaaaggga ttccgtagta ggtcaacatg agttgcacca aaatcggtgt   1270560
cccttttaag aaactaacaa agaaggcctg caagggatat aaaatcttga cacgattgat   1270620
cttcacaatg gcaaaaagaa gcgccaaaac caagccaaaa agggcaccac caattgtcaa   1270680
cataattgtt gttggaagtt gttggacaat tctagggatt ccatcaaaga ccgaacgtag   1270740
gctaaacagc ttgccatccg gaatcaattg catcaagttt tggtaccaat ctgatgctaa   1270800
aatcgttgta acattcataa aaacatcctc ttctgataat gattcattct accatgcttc   1270860
tgccgtcaat gaaattattt gctacggtca gatacagact ttgtctacct actagtttat   1270920
catactttga aacagggaag ttatatattt tatctatcaa agagatagat aaaaactatt   1270980
tcagtcccag ttcctcataa gattttcgat aaccgatttg cttaacagtt ccattttcta   1271040
ctaaaatggg ccgttttaac aacataccgt cacttgctag caactcagcc gcttcttggt   1271100
ttgacaaact tcctacctta tcttttagcc ctaattcacg gtatttgata ccactggtgt   1271160
tgaaaaattg cttcaattca aatcctgagg tttctagcca attcaaaatg acttcttggc   1271220
taggtgtttc ttccacgata tggacggctt tatagtccac acctaattga tttaattctt   1271280
gttttgcttt tttacaagtt gaacatttgg ggtattcgat aaattctaac atgtgcttct   1271340
ccttctattg cttctatctt taaaatctac tccttcatgc tccaagagcc aagctttctt   1271400
ttccactcct gcagcataac ctgtcagacg cttgcctgct cccaacacac gatgacaagg   1271460
tactaggata gaccaaggat tgcgtcccac tgctccacca attgcttgag cagaagccac   1271520
ttgcaggtct tgagcaattt gtccataggt cactgtctga ccataaggaa tgccctgtaa   1271580
atagtcccaa actctctttt caaaattcgt tccgattggc gccaagagca agttggataa   1271640
atcctgaggc ttgcctttaa agtaatcatc taagcaagca ataactgggt ctaaaatagg   1271700
atgactaaca acttcttcta tcgtttcatc tcctagtccc ctctcaaaat gcttctgctc   1271760
ctgaacccaa attccataca aataatggtc atcagctaca agtgatagaa taccaattgg   1271820
tgaggagtag aggattttta catacttctt ttgcattatt tctttaattt ttgataggcc   1271880
aagcgttcgc catctactgg catcttaccg acttgtttaa aaccaagttt ttcaaaaata   1271940
tgttgcataa ccttgttttc agcatgcgta tctgagcgaa aatcaagata atcaaaacct   1272000
tcaatcaagc cctctaagaa ggtttgagca actccttttc cctgcacatc tgctgccaca   1272060
gcaatacggt gaaagactag atactctgac tctccagctt gccagtttcc ctcataaata   1272120
gcttcatagg cctcctctgg actcttggtc acagcagcat aggctagcag ttctccctct   1272180
tccaaggcta cgtaggcttg ccctgagatg atatcatcga taataacatc tgcatttgga   1272240
tagccatttt gccactggtc actaccagca tctgctaaac attttttggc atcctccatc   1272300
acctgcatga tggcatctac ttcatttgga aaagctaaac gaatttccat cttttttcct   1272360
catttctgac tagtttctcc catcatagca taatttaagt atttctacaa gcagttaaaa   1272420
cttgactttg tgtttttgtt attttataat ctagttatca aaactatata aaaaggagtt   1272480
aaaaatgaaa actacctttt cctacccaaa atgggcagaa attccaaaca ttgacctcta   1272540
tctggaccag gttttgctct atgtcaatca ggtctgcgcc cctatctctc ctaataaaga   1272600
caagggccta acagcatcta tggtcaacaa ttatgtgaaa aatggttacc tgacaaagcc   1272660
tgacaaaaaa aaataccaac gccaacagat tgcccgtttg attgctatca caaccctcaa   1272720
gtctgtattt tctattcaag aaatagccca gacacttaat actctacaaa ctcaagcaag   1272780
ttcagaccaa ctctacgatg cttttgtgga ctacatgaac caaggaattg acccagctaa   1272840
ccctattatc caaaccagct gccaaaccgt taaactctat catcaaactc tagacttaat   1272900
cgatcatact caagaggagg taatccaatg aacactagtc ttaaactcag caaacaactc   1272960
agttttggag aggagattgc taatagcgtg acccatgctg tgggtgcagt catcatgctt   1273020
atcttgctgc ctatttcatc catctatagt tatgaagcac acggattttt atcctctatc   1273080
ggcgtttcca ttttcgtcat cagtctcttt ctcatgttcc tatcatccac catttatcac   1273140
tctatggcct atggttcgac ccacaaatat gttttgcgaa tcattgacca ttctatgatt   1273200
tacgttgcca ttgccggctc atacacgccc gttgtcttga ccttgatgaa taactggttt   1273260
ggctatctga ttattgtcat ccaatgggga acgaccatct ttggtattct ctataaaatc   1273320
tttgctaaaa aggtcaatga gaaatttagc cttgctcttt acctgattat gggctggttg   1273380
gttctggcta tcattcctgc cattatcagt caaacgacac ccgttttctg gagtctcatg   1273440
gtaactggcg gactctgtta tacagttgga gctggatttt atgccaagaa aaaaccttat   1273500
ttccacatga tttggcatct ctttatccta gctgcgtccg cacttcaata catcgctatt   1273560
gtttattaca tgtaaaaaag ttgagaaatt caatctcaac ttttttcttt acacatattg   1273620
ataaagtact ggtgcaagcg cacatcatca gtcaattctg gatgaaaaga acttaccaac   1273680
atattttttt cttgggctgc aacaatttga ttgttcactg ttgctaaaat ttctacaccc   1273740
tcaccaacac tactgataat cggaccacgg ataaaggtca ttggaatctt gccaactccc   1273800
ttacattctg cttccgtgta gaaacttcct aattggcgcc cataagcatt acgctcgacc   1273860
accatatcca tagttcctag atgactctct ttctgagaag tgatttcctt agccagcaaa   1273920
attaagcccg cacaggtccc aaacactggt aagccagata gaatggcttc tcggatggga   1273980
agtagcatgt tctggtcacg taagagcttg cccatggttg tagactcacc accaggcaaa   1274040
atcaaacccg acaagtcact ctgatcttgc tgaaaatcat ctagatttct gagttctaca   1274100
ctctcgacac ctaattgatc tagcactttt gcatgttctg caaaggcccc ttgcaaggcc   1274160
aatattccga ttttcatcta ttttcctcgt tcagccatga gaatttggat ttcattttca   1274220
ttaataccaa ccatggcttc tcctaaatct tcagagattt gagctaggat ttgaggatta   1274280
cggaagttag tcacagcctt aacaatggca ctcgctcgtt taacaggatc tcctgacttg   1274340
aaaatacctg aaccgacaaa gaccccctct gcccctaatt gcatcattaa cgcagcatct   1274400
gctggcgttg caacacctcc agcagcgaaa tttacaactg gcaattttcc atgttcatga   1274460
acatattgga ccaattctac agggacttgc aaatccttgg cagcaacata aagctcgtcc   1274520
tcacgtaagt tttgaatgcg gcgaatttcc tgattcatca tacgcatatg acgaacagct   1274580
tggacgatat cccctgtccc tggttctcct ttggtacgaa tcatggaagc accttcagcg   1274640
atacgacgca aggcttcacc caaatcctta gcaccacaga caaaaggaac ttggaattct   1274700
ttcttgtcca catggaaacg gtcatcagct ggagatagaa cttcactctc gtcgatataa   1274760
tcaatttcaa tagcctctaa aatctgagct tcaacaaaat gcccgattct gaccttagcc   1274820
attactggaa tactaaccgc ttcttggatt tccttaatca tctttgggtc gctcatgcgg   1274880
gaaactcctc cagctgcacg aatatcagcc ggaattcgtt ccaaggccat cacagctgcc   1274940
gcaccagcag cttctgcgat acgagcctgt tcaggattct gcacatccat aataacacca   1275000
cccttgagca tctgtgccaa gtttttattt agttcataac gattttcagt catttgtttt   1275060
atcctcatca tttgtattgg tagctacctt ttcattttaa gtcagaacag aatgaagcac   1275120
aagataaaaa aactataatt gtatggggac aaattagcta aaaactatct gaccttaact   1275180
taaggccaga tagctcattc atttttattt ttcagccgta agggcagcca ttgtgatgta   1275240
gttgtatggt ttgttgaagt gtggcaagaa gaagaggtct gtcaatgcca atttatcaat   1275300
tgtcacatgc tcttggatag caagtgagaa catgtggatt cccatgctaa ttgcaatatc   1275360
atgtgaaacc atttgggcac caagaatttc acggctatct ttgtcaaaga caatcttaat   1275420
tgctacttca tggttgtcat gtttcatgaa ttctggtttt tgaagatcgt taaagcctgt   1275480
ttcagttgcg ttgtaaccag cagctttcgc tttttcaaga gtcaaaccag ttgaaaccat   1275540
gtgaagaccg tagattgaga taccatttga accttgaaca ccgattcctt ccaattcatg   1275600
tccacaagca ttgtaggcac caacgatacc agtgcgaaca gcatttgaag caagagcgat   1275660
atagcttgta tctttacgag cattgtcata aacagtcgca cagtcaccaa cagcgtaaac   1275720
gtctgggata gatgtttctt gtttcttgtc tacaaggaag gcaccgttgc ggaagagttc   1275780
gatcttacca cctgcaaggg ctgtgtttgg acggaaacca actgcaagga taaccatatc   1275840
cacgtcaaag ctttctttgt cagtaatcaa gcgttcaact ttaccgtcac cttcgattgc   1275900
tttaacagtt tgacctagag ccaagcggat gttgtgatct tccaagttct tcgccatcat   1275960
ttgtgtgaag tctttgtcat agtaaccgtt caagacagta tcaacgatat caacaaggac   1276020
aacttctttt ccaagacgtt caaaggcttc agcaagttca acaccgatgt aaccaccacc   1276080
aacaacggcg atacggtcga ggtgttggct cttgtcagaa agtttattga taacttcttc   1276140
agcattttgg tacaatttca cgaattgtac gttttcaaga gttgctttaa attcgcggtt   1276200
tcctttaaca atttcaacac cttcgattgg tggcaagatt ggtgtagagc ctgtagcgaa   1276260
aatcaatttt tcgtatgatt ctttgtgctc ttttccttca acttccgctg taactacttt   1276320
gttatcatag tcgattgaaa gaacaggtga gttcatgtaa actttagcac ctttagcttc   1276380
caatttttct ttatcagaat agaacaagcc ttcagcaccg tcaatttgtt caccaatcca   1276440
aagagccatt ccacatccta ggaaagagat gttagagttt tggtcaaata caacaatttc   1276500
gttctcattt ccaaaattat ccaacatggt attgatacat gctgtaccag cgtggttagc   1276560
accgactaca acgattttac tcataaaaat ttcctgcctt cattctaaat ttaccttact   1276620
agtataccat ttaccgttag cgtttacaag gggggtacta ttatttcagc attttttatc   1276680
aaaaataatt ccccatttat cctgttttca agcctgatga attttatgag catatttctt   1276740
gactttttcc aaattttgtt tgtgaaaatt ctaactttat ggtattataa taacatgaaa   1276800
atgaaatgta agggcttcaa tttagatgat tatttgatat tacaacttat tttctataag   1276860
agaaaggagt tggtagcttg actcttcgtt cacattctga acggctaatg gggactacta   1276920
tcactatttc attagtggat gagcaagccg atatctttct ccaaaaatcc tttgacttgc   1276980
tcaaagaact tgaataccgc ttcaacgcca atagtcaaga atctgagttg atggaaatca   1277040
attatcaagc aggaatagcc cccgtcacgg ttcatccaga cctgtttgag ctgatttcac   1277100
ttgggttaga gcatagccta gcgctctcta gccacctcaa tatcagcatt ggtcccttaa   1277160
ttcaaacctg gcgtatcggt ttttcagatg ccaaggtcgc ccagcctcaa gaaattgaat   1277220
cggtgctgcc tctaatcaat cctcatggta tcgagttaga ttcttctact tctactgtgt   1277280
ttttaaaaca gaaaggaatg aagatcgatc taggttgttt agccaaagga tacagtgcgg   1277340
ataaggttgc ccaatttctt aggaaagagg gggtgacttc tgccttgatc aatctgggag   1277400
ggaatatcct gaccattgga aaaaatcagg caagagggga taacccatgg caaatcggga   1277460
ttcaagaccc agccaatcct aggggaaatc atttaatgac catccctgtt gtcaataaat   1277520
ctgtcgtgac ttcaggcatt tatgaacgtc acctgaccgt cgatggacaa gattaccatc   1277580
acatttttga cagtcaaaca ggatatcctg ttgaaacgga actagcgagt ctaacaatca   1277640
tctctgataa atcagtcgat ggcgaaatct ggacgactcg actctttgga gaaagacctg   1277700
cttctatcct ctggcaagtc gaaagtttgg agggcatcga agtcatcctc atcgataaag   1277760
aaggccacct aagctgttct tcaggaattc ctactctata gagacaactg tttcaatgga   1277820
attttaaaat tgtattatgt aaaaagagaa aggaaatctc atgttaaaac ttattgctat   1277880
tgttggaaca aattcaaaac gttctacaaa ccgtcaattg cttcaataca tgcaaaaaca   1277940
ctttactgac aaagctgaaa ttgaacttgt tgaaatcaag gccattcctg tcttcaacaa   1278000
accagctgac aagcaagtac ctgctgaaat attggaaatt gctgctaaaa tcgaagaggc   1278060
agatggcgtt attatcggta ctcctgagta tgatcactct attccagctg ttttgatgag   1278120
cgctcttgct tggttgtctt atggtattta cccacttttg aacaaaccaa tcatgattac   1278180
aggtgcttct tacggtacgc ttggttcatc tcgtgcccaa ttgcaacttc gtcaaatctt   1278240
gaatgctcct gaaatcaagg caaatgttct tccagatgaa ttcttgctct cacactctct   1278300
tcaagcattt aacccaagtg gcgacttggt tgaccttgat gttatcaaga aattggatgc   1278360
catctttgat gacttccgta tctttgtaaa aatcacagaa aaattacgta atgcacaaga   1278420
attacttcgc aaagatgctg aagactttga ctgggaaaat ttgtaagata ggagaccaaa   1278480
aagaatgaaa tttgttggac ttgttggatc aaactacgat caatcatata accgtaagct   1278540
cttggaattt atccgtcgct acttcaaact caaatttgaa ttagaagttc ttgaaattga   1278600
cgaagttcca atgtttaacc aagatgaaaa atgggatgaa agtttccaat tacgttattt   1278660
atataacaaa attactcgtg cagatggtgt tatcattgct actcctgagc ataaccacac   1278720
tatctcagct tcactcaaat ctgtacttga atggctttca tacgaagttc atccatttga   1278780
aaacaagcct gttatgattg tgggtgcatc atactatgac caaggaacat cacgtgctca   1278840
agttcacctt cgtaaaatcc ttgatgctcc aggtgttaat gcctacacgc ttccaggtaa   1278900
cgaattcctt cttggtaaag ctaaggaagc ttttgataac aacggaaata tcaccaacga   1278960
aggcactgtt aaattccttg aaacttgctt agataacttt gttaaatacg taggagtcgt   1279020
ttcgaaattg aaaaaaccaa aaccaatcga atcagaagac ttggattgtg gaaaaccaat   1279080
cgctacaacc atcacagaag ttgaccctga cgatccagaa tgggtagaaa aagttgcagc   1279140
attcactggt gctgtttctg gtgataccta tgtcaaattg gaccacggta tcctaacagt   1279200
taaccaaatt gatatgttct tgaaagctat gccatttgaa ttgacatacg ctgacgacaa   1279260
caaccaattc ctctactaca acaacgctca ccaagatcca gacactatgt tcgctaaacg   1279320
tgtaccacct caatcaggta gccgtatgtc gactgttcat ggttctcttc caccagcacg   1279380
tatgaagaac gtagagtggg ttatcggaac acttcgcaac ggaaaccaag aatacgtccg   1279440
tacgatcgtt ccaggttctc ctgcaggtgt tatcaacact cacaactacc aagcaatgta   1279500
ctatcctgat ggatcatacg ctggtatcaa tgaaatcgtc tttaacttcc aaccatggct   1279560
tgactggtac ctaaaagaga ctggtcaacg tttggtgggt ggtagcggac catttgctcc   1279620
tgctgccgga ggtcatggag acgccgatgc tacttctggc gcttctgatt caggggatgc   1279680
tggaggccac ggtggtgacg cagacgctac agccggtgca agttactaat gatagttttt   1279740
aggaaccatt atggttcctt ttttagcgaa aaaagactag caaacacaaa ctgctagtct   1279800
ctttgttatc gtttcatcta tctttgttaa aagaaagaat acatatactc aatgaaaatc   1279860
aaagagcaaa ctaggaagct agccgcaggc tgtacttaag tacggcaagg tgaagctgac   1279920
gtggtttgaa tttgattttc gaagagtatt attatgaatt tggatcatca agactacggc   1279980
catgtaatcc tttttcacgt tgtacttggc gtagtttttc tggtgtaaca tcgtttcctt   1280040
cttcgtccac aattttgatt ccttcaatgt ggtgacgaac agcgcggcga taaccttcga   1280100
tgtactcctc acgtagtttg gcttgttcca ctttttcttc tggtgttaag ccttctgttt   1280160
ttttcttttt agcaagctca ttgatacgag caattttttt cggatccatt tcttctcctt   1280220
tgtaataaga taaagtccgt ttatcaaatt ttatttagtg ttaatttggt taaaacaagc   1280280
aaacttagct gctttcttgg ttagttgtga caagattgcc aaacgatttt gacggacagc   1280340
ctgatcttca gccattacca tagtattttc aaagaaagca tcaatgactg ggctaagcgc   1280400
aaaaagttgt ttcaattgct gacttgcagg tcctgataaa atgagtgttt ctactgcttc   1280460
tgccaaagct ttttcttggt cattctcaaa tagtgctgaa tcaaccgtag caaccccttc   1280520
tgccttctcg gccaggttaa aggcacgaga aagtgattca acagatggtt taaaatcttc   1280580
ttccttgctt acttctacga gagcacttgc tgcttccaac atatctgcca caacaaagtt   1280640
tgaacctgca agaactgctt ccttgatatc ttttggagta gagcccatca tcttatcaac   1280700
acgagccttg ataaagtcca taacctctgc tttattttca taagtcaaac tgtcaaattt   1280760
caatgcataa aggctatcaa tcagctcatc catagcaatg tgccaaccaa aggcatccaa   1280820
gatacgaacc acaccttgag ttgcacgacg aagggcataa gggtcattag aacctgatgg   1280880
aatcaatcct actgagaaga aactcaaaat cgtatccaat ttgtctgcaa tggctagaac   1280940
tgcgccgacc ttgctctctg gaagttctcc ttcagctgat gtaggcatgt agtgttcacg   1281000
aatagcagct gccaccgctg gagtttcacc agcaagaagg gtgtattttt cacccataat   1281060
tccttggagt tcgtcaaatt caccaaccat acctgtcaac aagtcaaact tgtaaatggc   1281120
tgctgcacga gcaaggtcaa ctgtttcatc cactgacaaa ctagcttttt ctgccaaaag   1281180
tacagtgatt tgacccgtac gaatcatgtg ttcacgaaga gaaccaatct tctcatggaa   1281240
ggtgacattg tttaattttt caacaagatc tgaaatcacc aatttttggt cttcacgcca   1281300
gaagaattct ccgtcttcca agcgggctac caagactttt tcatttcctt tgatgacatt   1281360
tttcaaacgc tctgcgtttc cgttacgaac agaaatgaag tttggcaaga gttttccatc   1281420
ttgatcacga acaacaaagt aacgctggtg ttccttcata gaagtcacca agacttcttc   1281480
tggaacttca aggtatttag catcaaaact tcccatgaag gcagttgggt attcaaccaa   1281540
attcaagact tcattcagca aatccgcatc aatttcgata cgtacaccat gttttgcctc   1281600
aatttccttg atttggtcaa caatcatttg ctcacgttca catggatctg cgattacaaa   1281660
ctgcttacga aggtcttctt catagctcaa tgctgactga atcttggttt cttgtcccaa   1281720
aaaacgatgg ccacgactca cacgacttcc cttgatatca aggaaatcca agtcaaactc   1281780
ttgctcatcc aagagaacag ttaaagtgtg aacagggcgg atgtattcaa agctatttcc   1281840
cgcccagtgc atgctgacag ggaaagtcag tgacttcaag acatccacaa tgcctggaac   1281900
aatggcttca actgcttgac caatttcttc cttagtgaca tagacatatt cttcaccctt   1281960
gatttcacgg aattcgatat cttcaacagt caaacctttc ccacggacaa atccttgagc   1282020
tgctttggtg aagtttccat cactatctaa ggcaattttc tttgctggac ccttgaaatc   1282080
ttctgttaaa tcagactgtt tgtctgcaag accagttaca cgaacagcca aacgacgtgg   1282140
tgttgagaaa gtttgaatgg cttcaaaaga caggcgtttt cccttgagga aggctgccat   1282200
tttttcgcct agttgttttt cacttggcgt aacaacatag gctggtaatt cttcaagacc   1282260
gagttctact aataagtttt ttgtcatgtt ttttctccga aaagtatctt tttattttcc   1282320
agtttgcctt atgtgattgg cacgcaagca accaacttcg ttgtttcatt gctaaaattg   1282380
gagccaaaag tctccaattt tgcctagtat ccttagtttc actaaggata ccttcatcac   1282440
tgcggcaact ggctcagggc tcactctgtt cgcccatttt cgtaatttgt cactctcttt   1282500
attctgcgtc ttctgctagg agtttagctc ttgtttcttc atccaaaagt gggtagccta   1282560
ggcgtttgcg ttctgcgaca aaggttttgg ctacgacacg ggccaagtta cggatacgag   1282620
cgatatagcc tgcacgctct gttacagata cggcaccacg cgcgtcaagc agattaaagg   1282680
tatgtgaaca tttgagaaca tagtcatagg cagggtgtac caagccttct tctaatgcac   1282740
gaccagcttc tttttcaaac ttatcaaagt tttcaagcaa catttcttgg tccgaaattt   1282800
caaatgaata ttttgagtgc tcatactcag gctggataaa gatttctccg tattttacac   1282860
catcagccca ctcgatatca tagacagagt ctacttcttg aatgtaagaa gccaagcgct   1282920
ccaaaccata ggtaacttcc gcagtcacag ggccagttgc caatccaccg acttgttgga   1282980
aataagtgaa ctgagtgatt tccattccgt caagccaaac ttcccaacca agaccagctg   1283040
aaccagttga tgggttttcc cagttgtcct caacaaaacg aatatcgtgc tccaaaggat   1283100
tgattcccaa tttttccaaa gactcaaggt aaagttcttg gatatttgat ggagaaggct   1283160
tcatgaccac ctggaattgg tggtgttggt agagacggtt agggttttcc ccataacgac   1283220
cgtcagcagg acgacgtgat ggctctacat aagctgcatt ccatggctca ggtccgatag   1283280
cacgaaggaa agtgtaagga ctcattgtcc ccgcaccttt ttcattatca taagcctgca   1283340
taagcataca atcttggtca ttccaaaatt gttgcaaagt caaaataatt tcttgaaatg   1283400
ttaatttctt agacattgaa tactccttaa taaaaaataa tttcttgcga cacgagtctg   1283460
cctcgtcgat tatacgaggc aagacgagtt agtactgcgt ctagctcagg cactctagtg   1283520
ctgagcgtag ggcagtccga ctgtaaggag gtttctgcca ctgacgcagt gaaatgttaa   1283580
tttcttagac attgaatact ccttaataaa aaataattac ttgcgacacg agtctgcctc   1283640
gtcgatcata cgaggcaaga cgagttagta ctgcgtctag ctcaggcact ctagtgctga   1283700
gcgtggagca gcccgactgt aaggaggtct ctgccactga tgcagtgaaa tgttaatttc   1283760
ttagacattg tttactcctt tagtttttat atttcttttt caattaattt ctgctgaaca   1283820
aaccaatcta acaagggaaa agttttttct gtatttgccc ataaatgata agaatctaag   1283880
accgcttgta cactacctaa attttctacc aacttatcta ctgtcaaaaa gctgcgccag   1283940
tattcataaa aaatacttgc atagttctta tcataagtcg aagaaccaaa atcattcaat   1284000
gaatgccaac tatacttctt ctgaaaaagt tctacgagag attgattaca aattttttcc   1284060
gcttgaaatt cctcttctgt caagaaatac ttgcgactaa tatattcaac catcccctct   1284120
tcgaaccaga tataagagtc ataaccatca aaatcatcta aaaaatgtcc gaccaatgag   1284180
ctaactcatg tcctacaatc tgtaagagga aattttcaga taaagaatga tagtgacttt   1284240
ctattgcttg agtttgctca gaacactcgt agtccatcaa ctgatacaaa tacaattctt   1284300
tccaaacagc taaatcaggc gtcataacca ctcgtctatt atttgtatag gttggaacag   1284360
cactttccct aataatctgt gtagcagcat taaaatctga ccaaataaca gcttgcggta   1284420
aatcacagac tgcaagttca ttctttaaaa aagattgata atctttcaac ttttcagtat   1284480
ttcttactac aaaatcacga aatgtagcta gttgactatc gtcttttaca agataaaggt   1284540
tgtccacggc tctcctttct ttcacacaat agactgaata agcaaaagaa ccacatctga   1284600
caatcctagg ttgatttaac ctaggggcgt cagaaacgcg gttccaccct aatttattac   1284660
ttcattgttt ttgaaaatac tacagaaagc gccagccctt tattttgccc tacttggctc   1284720
ccactatccc aagctcgctt gaagaacgcc ataagacttt ctttcctgct gactattata   1284780
tcaaaaatta gaataatgta caattctttt tatgattttc tagaaatcca catcatcaac   1284840
tcgtggagca cccgattgaa cagcaatcgt ttttaaggtt tctctctcct catgactcag   1284900
ttcaattcca aagcaatcaa gattagcttg aatacgagag gttgtgacag attttggaag   1284960
tggtaaaaat ccttctgcca agctccaggc caaggctatc tgagcaaccg attttccgtg   1285020
atttgctgct atttcttgga cttgcttgct atcaaacagt tctccttgtc caaaaggccc   1285080
ccaagcttcc aataaaattc ccttttcacg acagtaagct acgacttgat cttgatacac   1285140
acctggcgcc aagcgaactt gattgaccgc aggaacgata gttgcagttt caagcaaggc   1285200
atccaaatga tggggaagaa aattgctaac gccgatagca cggattttcc cttcttgata   1285260
gaggtcttcc atcgctctcc aaacttccgc attgcgagtt ttccatgcgt cattttctct   1285320
gagcggtttt gggttcggcc aatgaatcaa atacaaatcc aaataatcca agcccagttt   1285380
ttctatagat ttttccaaag cttgacgagt ttgctcatag gtttgctgac tattccaaag   1285440
cttggtagtt acgaacattt cttcacgtgg aactccgcta tctttgattg cttgaccaac   1285500
actttcttca ttctgataaa tcgccgccgt atcaatatga cgataaccag ccttcaaggc   1285560
ttctaacact gcacgatagg cttcttctcc atccttagcc ttaaaagttc caaatcccaa   1285620
tactggaatt tctactccat tatttaattg ataggtattc atatgcttct ccttctattt   1285680
tattcatcaa ttatagcata aaacattttt taagtagtac tatattctgt aaaaaataag   1285740
tctgtcaaat atctaacaga cctatttttt cttgcttatt catcacgact atagtacagc   1285800
tcatgagctt ttaggcgagt attgagcatc tctggtatgg tcacaaaggt ataaccttga   1285860
tttttcaaat actcaatgac ccttggcaag gcattgactg tcggactgtg aatatcatgc   1285920
atcaaaacga tagagccatt agctacttga tactgaattt ctgtcaaaat agatgcttca   1285980
tttttactct tccagtccag actatccaca tcccacatga taaagctcaa atccaagcta   1286040
ttgcgaatat catctgtaat agcaccataa ggtggacgca tgagtttaga actagaaccc   1286100
agcactttag ttagcacatc ctcagtatca gtaatctgct ttttagcttc atcaagagag   1286160
agttgcgaga gaatcggatg gctccagcta tggtttccaa caacatgacc ttcagatttt   1286220
atcctcttca ccaagtcctc attcccagaa acatttttcc caagcacaaa gaaagtcgct   1286280
ttaatatcat atttagctag ggtctctaat acctgcgggg tcgttgctgg atttggacca   1286340
tcatcaaagg ttagagcgac aactttttga tgtttcttat caaagtaaga ttggtacaag   1286400
gccgcatctt tttcgagtaa gtacgaagat tggataacat caaagaaagc agatactggc   1286460
aaggctatct cttctaaatt ttcaaccaca ggacttggat aaaggataat ctgactatcc   1286520
ttgtaatcaa aattccatgc agacaagtct tggtcagaga agttttttac aatctgctca   1286580
ctctggtctt gctctatttt tttatcctct atgaaggagg tcaactcttt tatcagctgt   1286640
tccttagcct tactagcatc tgaaaacagt tggtcaagtg taaaaggttg cccatcttct   1286700
gttaagtgaa cctttcctag actggtcttt tcagtctctt caatcttaaa agcaactaaa   1286760
tcatagattt gtttggtcac attacgatta acgactccct ttaaacctga ctcttcttgc   1286820
tctgtatagt agaaaacaag attgtcctta ctttctagct tgtccttaac atcttgattt   1286880
atcagctccc taacagagga aatcactttc tccccttgga gaggataata ggcaatcact   1286940
tcggcttgcc cctgacgaaa atgctccttc tgatttccct cactcaattg atcatctttc   1287000
tcttttttga gcgattcaat cttttgctca aaactttttt gctggtagat cttaaaagca   1287060
ataaatccgc ctaataggca aatagaaatt gctaaaatac caatcaaagc caataataca   1287120
tgtctcgttt tcccgtgtct gccacgtcct agtctacttt tattcatatt tatatcataa   1287180
caaatttgag caataatttc aatgatacaa tttggcaatc cacaattcct ctagcaagcc   1287240
aaagcatctt acatcaactc caacatccgt atctgtagag attatgtagt tttctatcta   1287300
tggaatttct agtagattga agctagaata gtagacctat acttctaaaa cattgttaga   1287360
aatcgatttg actgtcctga tcgatttgtc ctgttctcat ttcattttac tataaaacta   1287420
tgaaaagcta ggtcatctga gaagtaatta ctatcgacaa ttgcgatagc gtatactagt   1287480
gcgatttgtt tgtagctctg gtgggtatca ccttcacgtt ggcgaatttt ttctaggttt   1287540
tgattaacct gactgcacag ataaggccat aggcgattga tgaaaaaatt ctgatgatga   1287600
acctgaattt cgatgataac ttggattcca ttatctaact ccgccaagac gtctatacta   1287660
gtatagaaat cttacgctga gtagggcatg gaaggcaaga cgtgaatgtt acttccctcc   1287720
aaaatcgtca cattttttgc tggcaagtcc agcatatcgc ggataaattg acaaatcatt   1287780
agttgggctg atacctagat gtctgagaat cctccttttc ctccttctat tatagcacat   1287840
ttttaaatct aggtttgcta gattctatgc ttctatctat ttattcggaa aagaaagcta   1287900
atagcttatt tgaaattttc tcctctctgt tggatagtcc cgtctatcta tgttataatg   1287960
aaagaaggat ttaaaatcgg aaaaggagta tttatgctaa aattaggtgt catcggaact   1288020
ggcgctatca gccatcattt catagaagca gcccatacca gtggagaata ccaactggtc   1288080
gcaatctatt ctagaaaact agaaactgca gcaacctttg cttctcgcta tcagaatatc   1288140
caactattcg atcaattaga agtcttcttc aaatcttctt ttgatttagt ctatatcgcc   1288200
agtccaaact ccttacattt tgctcaggca aaagctgcct tgtctgctgg taaacatgtt   1288260
attctcgaaa agccagctgt ctctcaacca caagaatggt ttgatttgat tcaaacagct   1288320
gaaaaaaata actgttttat ctttgaagca gctcgtaatt accacgagaa agcctttact   1288380
actatcaaaa actttttagc agataagcaa gtgttaggag cagatttcaa ctatgccaaa   1288440
tactcttcca agatgcctga cttgttggct ggacaaacac caaatgtctt ttcagaccgt   1288500
tttgctggtg gagccctcat ggatttgggg atttatcccc tctatgctgc tgttcgtctt   1288560
tttggaaaag ccaatgacgc gacttaccat gctcaacagc ttgacaatag cattgaccta   1288620
aatggagatg gtatcctctt ctacccagac tatcaagttc acatcaaggc tggaaaaaac   1288680
atcacttcca atcttccttg cgagatttat acaacagatg gaaccttgac tctcaacacg   1288740
attgagcata ttcgctcagc tatttttacc gaccaccaag gaaatcaagt ccagcttcct   1288800
atccaacagg ctcctcatac gatgactgag gaagtcgctg catttgcaca catgatccag   1288860
caaccagatc tgaatctcta ccaaacttgg ctgtatgatg caggctctgt tcatgagcta   1288920
ctatatacca tgcgccagac tgctggcatt agatttgagg cagaaaaatg aaaaccaaac   1288980
taccgactga atggcaagaa ctgagtgacc aactcggttt ccaagaattc acccccattc   1289040
aaactcaact atttgagccc cttcttgctg gagaaaacct cctaggagtg agccaaaccg   1289100
gaactggtaa gaccctagcg tatctcctac caagtcttct cagactacaa aagaaaaaag   1289160
cccaacaact cttgattcta gcaccaaata cggaacttgc tggacagatt tttgatgtat   1289220
gtaaaacgtg ggcagaagct atcggattga ctgctcaact cttcctttca ggttcaagtc   1289280
agaaacgaca aattgaacgt cttaaaaagg ggccagaaat tctgattgga actcctggcc   1289340
gtatctttga actcattaaa cttaaaaaaa tcaagatgat gaatgtggaa accatcatcc   1289400
tggatgaatt tgaccaatta ctagatgatt ctcagattca ctttgtagaa aaaatcactc   1289460
actacgcacc tcgtgaccac caactggtct acatgagtgc cacgaccaag tttgaccaag   1289520
aaaagattgt gccgaataca cgcactattg atctctctga tcaaaaattg gacaatatcc   1289580
agcatttcta catgcaggta gaccaacgtc atcgagtgga tatgctacga aaactggctc   1289640
atgtagagga tttccgtggt ctagtcttct tcaatagcct gtcagacctt gggaatgccg   1289700
aggaaaaact acagtatcgt gatatattgg ctgtttccct cgctagtgat gttaatgtta   1289760
aatttagaaa aatcatctta gaaaagttta aagataacca actaaccctg cttcttgcaa   1289820
ctgacctttt ggctcgtgga attgatatcg atagcctaga atgtgtcgta aactttgata   1289880
ttcctagaga tagcgaaacc tacacacacc gtgctggccg tactggtcgt atgggcaagg   1289940
aaggttatgt tatcactctc gtcactcatc cagaagaaat caaaaaactt aaaaagtttg   1290000
caagtatccg agaaattgtc ctaaaaaacc aagaactcta tatcaaataa agccccattg   1290060
ctctatacac atccagtgta tggagctttt ttataagcaa ttcaatttta tactcatctg   1290120
ttttcaaaaa gcattctagt ccatctccga ttaacgatgg actttatcac ctccttctcc   1290180
aatccttgta tgacatcttg gagttgattc atgacatctt ccaaagttcg aaaggcttta   1290240
ttcttaaatc cacgtttacg aatctctttc cacacttgtt caatgggttc atctctggtg   1290300
tgtatggagg aataaaggta aaaccaatat tagtcggaat ctttaaggta cttgatttat   1290360
gccatatagc attgtccata acgagtaaaa gataatcatc tggataagct tgtgaaagct   1290420
cttctaaaaa ggcgttcatc cactcagtat tacatccacc agctattaag aaaaatgatt   1290480
cgcctgtatg ggcatcaaca gctccataac aatagcgaaa ttctcgtata tagtgactat   1290540
ggacatgtgg acctactcct attggagacc aacaagatcc cagtttactg attctaccga   1290600
aaccagcctc atcttggtac atcaagcgaa ccttatgaaa aggtctactg gttttaaagc   1290660
gctttcttgt gtactgcccc caaacagtta gacaaataat ttatccaaag gatttagttc   1290720
tgtactgcac aggactaagt ccttttagtt ttatcttaat tttcttattg ttgtaataat   1290780
caatatagtc tataatggct tgttccaatt ggttaagtga tttaaatgtt ttctcatagc   1290840
cataaaacat ttcggatttt aaaatgccaa agaaagattc catcctaccg ttgtcttggc   1290900
tgttgccctt acgtgacatg gatgcttgaa ttcccttact ctctaggaac cgatgataag   1290960
aatcgtgttg atattgccag ccttggtcac tatggagaat cgtattctcg tagtgcttct   1291020
ctttgaatgc ctgttccaac attgtttgta cttgttctaa attaggcgaa caagaaagat   1291080
taaaagcaat aatttcactg ttaaagccat ctaaaactgg tgataagtaa agcttttgag   1291140
tacttgctgg aatggcaaat tctgtcacat ctgtgtagca cttttccatt gttttagagc   1291200
cttcaaattg tccttgaatg agattctctg ccttcttgcc aacgtctcct ttatgagaag   1291260
aatattttcg tttctgtcgc attttagctt gtaaattgag tacttttatc aagccttgaa   1291320
ctcttttatg atttaccaga taaccacgat ttcttagttc taaataaatc cgacgataag   1291380
cataatttcc cttgtgttcg ataaaaatgg attgaatttc agctttaagc tcttggtcct   1291440
tatctggttt atctagctgt ttcaagtgat agtagtaggt caaacgagct agtttaatgg   1291500
cttttagaag aatatctaac gaaaactcag tcattaattc ttgaataatt tctgtctttc   1291560
ttctttctct ttttcctcct tcaatcggag ttctcttaac ttttttagga tggcattctc   1291620
cgctctcagg tactctccct cttgttttct caacaatagt atacccgttt ttcctgtatt   1291680
gtgctagcca gttaagaagt atcgtacgac ttgggagaca gtattcaaga gaaactctat   1291740
ctttagtcca gccttcatgt cagactttat gaatcatttc ttgttttaaa tcaggagaat   1291800
agtaacgatt ttttcctttt ttgacgaact ctattccgta acgatcaatc aatttaatca   1291860
tgtacctaag attagaattg tttatcccaa atttatttga aagcttctct aagctatatc   1291920
cttgttttct aagttcatag atctgaactt tatcatcata agttaatttc ataataaaaa   1291980
caccccaaaa gttagatttt ttctgtctaa cttttggggt gcagttcact tgtcttcttg   1292040
aattgagact ttatttttag acgcgacaat ggtttgagca tctgctttct taggatgttc   1292100
tggacgtggc gtaatatttc gccaaccatg gcgcttcaac agttgataga aggcatcacg   1292160
tgtgtaggaa cgacctaact cctttttata agcctgaaat aaggcatcaa ttgtaacaaa   1292220
ttctcctgcc tctgtagcct tcaaatggcg ggcaagaaag actttctctt gctcaaccgt   1292280
catataagca tggttacgac caccacgtgt ttcttgaagg agagagtcga gtccgaactc   1292340
ctcatatttt ttacatttcg ccaaatcgtt gtttgattac agtctaaagt gtattgaatc   1292400
tataacagta caccttggct gctaaaatat ttctataaat tagtttgact ttcctgatag   1292460
agttgttcac atcttatttc aaaccactat aaaagttcta taatctcttt ataagatttg   1292520
cccatcagac gaaatagaac gatttgaagg cgtttatgat atttagctgt acgagagtct   1292580
tttaaaagtg ttttgatggt ttggatttct tctttaattg atttcatatt actattgtat   1292640
aatgcttttt gattttagtc tagtattata ctcttcgaaa atctcttcaa accgcgtcag   1292700
cttcgccttg tcgtatagat gttactgact tcgtcagttc tatctacaac ctaaaaacaa   1292760
tgttttgagc agtctgtagc taactttcta tagtaaaatg aaataagaac aagacaaatc   1292820
gatcaggaca gtcaaatcga tttctaacaa tgttttagaa gtagatgtgt actattctag   1292880
tttcaatata ttatagtttg ctctttgatt ttcattgagt attagttcaa tatctaaaaa   1292940
aagaaccttg ccaagcaaga ttcttttagt gtctaactta aataattgtt cttctgggaa   1293000
ctaaatcgaa ttaagcttcg atttctgtaa ccatacctga accaacagta cgtccaccct   1293060
cacggataga gaatgtagta ccttgttcta cggcgattgg gtgaatcaac tcaacgtcga   1293120
ttgtcacgtt atcaccaggc attaccattt cagtacctgc tggaagttcg attgaacctg   1293180
taacgtcagt agtacggaag tagaattgtg gacggtagtt gttgaagaat ggagtgtgac   1293240
gtccaccttc ttctttagta aggatgtaga cttcaccttt gaatttagtg tgtgggttga   1293300
ttgaacctgg tttagcgata acttgtccac gttcgatttc atcacgttga acaccacgaa   1293360
gaaggacacc tacgttatct ccagcaagac cttcgtcaag ttgtttacgg aacatttcaa   1293420
caccagtaac aactgctttt tgagtttctt ctttgatacc aacgatttcg atttcgtcgt   1293480
tgactttaac gataccacgg tcgatacgtc ctgaagcaac tgtaccacgt ccagtgattg   1293540
agaatacgtc ctcgactgga agaagcaatg gtttgtcagt gtcacgttct ggttctggga   1293600
tatactcatc aactgtgttc atcaattcca taacgatgtc ttcgtattta gagtcacctt   1293660
caagagcttt aagtgctgaa ccttggataa ctggaagatc gtcacctggg aagtcgtatt   1293720
ctgacaatag gtcacggatt tccatttcaa ccaattcaag caattcttcg tcgtcaacca   1293780
agtcaacttt gttcatgaag acgataaggt gtttaacacc aacctgacgt gaaagaagga   1293840
tgtgctcacg agtttgtggc attggtccgt cagttgaagc tactacaagg atagctccgt   1293900
ccatttgagc agcaccagtg atcatgtttt taacgtagtc cgcgtgtcct ggagcgtcga   1293960
tgtgagcgta gtgacgtttt tcagtttcgt actcaacgtg cgcagtgttg atagtgatac   1294020
cgcgttcgcg ttcttctgga gcagcatcga tagacgcata gtctttaggt tggttaactg   1294080
atgaaggcaa gcgacgtgcc aaaacagttg tgatagctgc agttagggta gttttaccgt   1294140
ggtcaacgtg tccgatagta ccaatgttaa cgtgtggttt actacgatcg tatttttctt   1294200
ttgccatttg agtaaaagcc tccaataaaa tatattttat agatagacag taggcaatac   1294260
agtctaactt tccttactat tttatcaaat ttcagctaaa ttgcaagtgt tttacaacgt   1294320
ttttgtgaat tattcttggt aaaaatttaa ctaattaata gaaagtacta aatagactta   1294380
tccttcaagg agttttcagc attatccatc cactcacttg ctgaaaatgt aaacagtctc   1294440
tggtttatat agtaaaatga aacaagaata gggcaaatcg ttcaggacag tcaaatcgat   1294500
ttctaacaat gttttagaag tagatgtgta ctattctagt ttcaatctac tatacaacct   1294560
caaaactgtg ttttgaacaa cctgcggcta gcttcttagt ttgccctttg attttcattg   1294620
agtataaaat tgcagataaa acgataacaa tcataggact cagcagagtc aatgtaggtc   1294680
gaagaatagc ccccctaatc gcttatttta tagtaaaatg aaatagaaac tgaacatttt   1294740
gttgaggaag gtaaatcaat tcctcacaat gtttgagaaa gaagggagga ctattccaac   1294800
ttcaacccac tataaagcag acttacaaga tagggaaccc atctccgata atattccgat   1294860
aatatatagt agaatgaaaa ctgcacaatt tgattggaga attcaaacca atttctcaca   1294920
atgttttaga aacaagggtc tattatttca actgcaacct actatagtcc attgaagctg   1294980
gaatagccca ctgagacttc taaaccactg ctggagagga gtttgtttag agtttctttc   1295040
atttccctaa aaaatcaaaa agagagaacc agtctgatcc tctcttactt atagatggtg   1295100
ctcactcaaa tgttaaagga gctatttctt agagataaag gaatttgaat acagctactg   1295160
ccgcaattgc tgctgcgata ggtgctacta ctggtaccca agaataccac cattttgaat   1295220
cgcctttatg ctcaccaaga actgatttgg gaaggaaagc atgaaggaga cgtggtccca   1295280
agtcacgggc tgggttcaag gcaggtcctg taggtcctcc aagtgatgtt accaaagcca   1295340
taacgaggaa tccaagtgcc aagtgagcca cagaaagtcc tgaagcagtg tgtggagcca   1295400
cctgtgcttt aatagccaag tcagaaaaat caactgtttg tcctgcttct gttgcctttt   1295460
gtttcatgaa ttgaagcact tcagcaccaa agaagttttt agtcaaacca agagctgcaa   1295520
agaacaaaac aaatgaacca acaaactcat taatcaaacc attgacagtt gctgcatagc   1295580
gactttcttt tgtaccatgg tcaatacttg aaatagttga gaaagttccc aagatgttat   1295640
ttgggttttc agttttcaag tagaatggac ggtatgttgc cacaactaag gcttggccaa   1295700
agatagcccc caagacttgc gcgataatgt aaggtaccac ttgtgcccaa gggaaaagac   1295760
cgctaactgc aagccctaga gtgaaagcag ggttgatgtg attcccagat acgttaccaa   1295820
acatcaaggc tgggatcata acccccatac cataaccaac agcgatgacg atccagccac   1295880
tttggtgacc tttcgtacct ttaagttcaa cgttggcaac tgcaccattc ccaagaatga   1295940
tcaaaatggc agttcccaaa aattcagtgg catacttcag tgcccatgtg aaatccattt   1296000
gctagattct ccttaaaatt ttttagatat tccttatttt atcaattttt accctattta   1296060
gcaactgatt tctggaaata tttttaaaaa aataggattc atagtttccc agttcaacag   1296120
acttgtaagc gtttttattc tttacgaaag acctcgttct caaaaccagg aaaaaagccc   1296180
acatctgtga gcttttcctg gttcctagat tctaaaatct attatttttc atcttctttt   1296240
ttcttgaaaa atcctaatcc tagaccagct aacaaggtca tgataccagc actagccaag   1296300
gtagcattag cttctgtacc tgtgtttggc aattcctctc tcttacctgt ctcataagtc   1296360
ggaacttctg ggtctggatt cactggagtt tcagtttttg gagtacctgg ttctggagtt   1296420
ggtttatctg gtgttggagt ctcttgattt ggtagttctg ggtttggtgt cggaacactt   1296480
ggatgctctg gatttggttg tgggattggt ttttctggtg ttgataaacg gtcatacctt   1296540
accgttattt ctttatcact agagtctgac gtaacttctt gtgattcaac tgttggaata   1296600
tctggatctt tgtacttgtc aatcttacca gatataacct cgtcccagtt tcctgttgtc   1296660
cattcaccgt aggttacaac tcccgtgacc ttgttctcag tttttgtacg gcttaaggtt   1296720
acaggttgaa caacatcttc ttttacattt tggttcgtaa ctttatcaac gtaatgaatg   1296780
atacgcgtta tagtcttcgt ctcagtagag gttgctgttt tgggaaccac tgtttcctca   1296840
acattctcac ggtagtaata gtcaactgtt gcaccgtctt ctggtacgca ttttcaggag   1296900
ttgctaccaa ggtgtatgtt gttttccttg tgataactcg gtcttctttg tcctcagttg   1296960
ttgttttccc ttcaatagtt tttgattctg tggtatactc agaacctatc gctaaatcag   1297020
cttttataac agactctacc aacttctctt gcctaccttc tttatagtaa ttggctgtta   1297080
ctgtagcagt ggttggcgct tcgctttctc tataaactaa ggtcactgtt ctaccttcgc   1297140
ttacaatatt cccagttaaa cttgcagaat ttgtatctgc ttctttaaaa gtataatatt   1297200
ttccgtcagt agtagtcatg ctactgagtt ttttatctgt gacattatag ctggtaccaa   1297260
tcagttgttt tttattggta atgtaggttc cgtcactttc tttttctcca attccagtat   1297320
catttttcaa tgatagcaaa cgcccttgtt catcaacata gcgaactttc acattttctg   1297380
agattagttc tgccaattct gaggtttttt tctttttctt gatttcttcg gttattttcc   1297440
ctttctcttc ttcgggaata tttagttttg gaatgatttt ttcaacaacg gttcgtgatg   1297500
gttccacagt atcttggatg actgaaaagt cagctagaat tgggagatta tactgaacac   1297560
ggtgactttg agtgtttact cctactcttt cattattctc tgaaaatact tgtacggtat   1297620
aagaaacaac atcttttcct aatagaacat ccccagtaga gaaatagccg ccttttccta   1297680
gtttgctatc tccagagccc acttctttcc taatcttatc agatagtttt ttaccagtca   1297740
gtacattcgt tcgcacaatc cctttgtcta cccctacaaa gtgggagaac tttttgaact   1297800
cttcagaacc agatctagcc caaccattat taagggcatt tgcttttgta tttgtattct   1297860
ctctcaaaag tttggcgatt agaattatat tcatcggcac ttagagttgc tgctatatct   1297920
gactcttgaa taccaacttc cttactacca tttctagcgg cagtatatgt gtatttatct   1297980
gtttctactt ctagctgatt atccttaaca tgataggtaa ttttctcctg gtataagagt   1298040
cttcagtagt ttatatactc tgtcatcatc tttagcttta gaagcagctg agtttagcca   1298100
agttggggta ttaggagtat ctttatcaac ctgtttcaag acattattca agtcatttgc   1298160
tagcctattg gttatcctca ctgtgaaagt tttcttccag tctgaaccac ttttattaga   1298220
cttagatatg ctcatgaaat cctggtcaac attcaacaca atatcgcctt gttttttagc   1298280
atcttccgtt gcttctgctt caaattgatc atggagtttt tgttgctctg gtgtatagtt   1298340
tttttattta cacgatttaa tgtactattt tttattttag tattaagaac tccattaata   1298400
cgatttttaa actctgcttc aaaaaatccc ttaatttgtt ggtgcgcaag ttcaacattc   1298460
aaacctttct tatacaagtc ttcattctga tacaagtctt cattctgaac gatttcggct   1298520
acacggtgaa tggtttgatt gtataccgtc ttctcttaac cagcagtatc cttagtttta   1298580
atgactactc gataggttcc tttagaaccg ttatagtcat ctagttttaa aaaagcattc   1298640
caaacattca aaaatagttg gaacttccct taatacatcc gtcactttct ttttcaagat   1298700
agcccaagct tgctcaatag gattcaaatc cggtgaataa ggtggtagag gtaagaaaaa   1298760
gtgtttatct tggatgcaga gttcatccaa aatgttcttg ggatgaaaac cagcattgcc   1298820
catgacaata acatgaggtg tcttcaaagc aggtaggagt tgcgttttga accactccac   1298880
aaagaaatcg cttgtcatgc ttttcttgta aatcatggga gctataaact ctccgtctac   1298940
ttgtcctgca acaattgaag ttcgctcaaa acgacgtccg ctaatctttt catagacttt   1299000
ctcccctcta ggagcccctg cataaggacg atagagatag cggtcgattc ctgtttcatc   1299060
aatataaaca ggtgctaggt gctttaaact attaaaattc ttaagaaata aggctacttt   1299120
tctgggtctt gttccttaaa gctcgtcatc tttttttaaa gtgaccttaa tctgctttaa   1299180
agctgcccat actgaaggaa cagcacaatc aaaatgtgcc gcaatttccc gtaaaaaagc   1299240
atctggatga gcctctacaa aggctttcaa ttcctctaaa ggaatctttc ggtttttgac   1299300
gactcgcttt ttcctctcta tgtgttcttg ttcacgtctt tcttttccca cgtgaagaga   1299360
gttctgacgc caacaccaaa aaacttggct gcctcgacat ggctgtgccc ctctttgatg   1299420
taatctaatg ctcgctgttt aaaatcagta ctatatgcca tagctttatt ataatatgct   1299480
tgtttaaaac taagtaacta tatcaatgtt ttgttatgag aagacttact ttttttactg   1299540
aaattgaatt tttcctagcc tcaacatcat ataaccccaa aattcaatct gacctggttt   1299600
gaagagatgt tcgaagcaga taaggtttta ctaaaactaa aaaaaatgat ataattaaac   1299660
tgattaaatg ttttaaaaat aaaggagaat ttgaatgtct taccaagaaa attaccagaa   1299720
atgggttgat tttgtggagc ttcctgacta ccttcgtcaa gatttggaaa atatggacga   1299780
aaaaactaag gaagatgcct tctatacaaa tcttgaattt ggtactgcag gtatgcgtgg   1299840
cttggttggt gctggtacaa accgtatcaa catctacgtt gttcgccaag ctactgaagg   1299900
attggctcgt ttgattgagt caaaaggtgg aaacgagaaa gaacgcggtg tagcaattgc   1299960
ctacgatagc cgtcacttct cacctgagtt tgcctttgaa tctgcggcag ttcttgctaa   1300020
acacggcatc aaatcttacg tatttgaaag ccttcgtccg actccagaac tatcatttgc   1300080
agttcgtcat ctcaactgtt tcgcaggtat catggtcaca gccagccaca accctgctcc   1300140
atttaacggt tacaaggttt acggtgaaga cggtggacaa atgcctccac acgatgcgga   1300200
cgctttgact acttatatcc gtgcaatcga aaacccattt gcagttgaag ttgctgatgt   1300260
ggaaactgaa aaagcttctg gcttgattga agttatcggc gaagctgttg acatagaata   1300320
ccttaaagag gttaaggaca taaacatcaa cccagccttg attgaagaat ttggtaaaga   1300380
catgaagatt gtctacacac cacttcatgg tactggtgaa atgttggctc gtcgtgctct   1300440
tgcccaagca ggatttgact ctgttcaagt tgttgaagcg caagcaactg ctgacccaga   1300500
cttttcaact gtaacatctc caaacccaga aagccaagca gcctttgccc ttgctgaaga   1300560
acttggtcgt caagttggtg cagatgttct tgtcgcaact gacccagacg ctgaccgtgt   1300620
tggtgttgaa gttcttcaaa aagatggtag ctacctcaac ctttcaggta accaaatcgg   1300680
tgctatcatg gctaaataca tcttggaagc tcacaaaaac gctggaactc ttcctgaaaa   1300740
tgccgctctc tgcaaatcta tcgtttcaac tgacttggta acgaagattg ctgaaagcta   1300800
cggcgcaact atgttcaacg tcttgacagg tttcaaattt atcgctgaaa aaatccaaga   1300860
attcgaagaa aaacacaacc acacttacat gatgggattt gaagaaagct tcggttactt   1300920
gattaaacca tttgtacgtg ataaagatgc catccaagcc gttcttgtag ttgctgaact   1300980
tgctgcctac taccgttctc gtggtttgac acttgctgac ggtatcgaag aaatctataa   1301040
agaatatggc tactacgcag aaaaaacaat ctctgttact ctttcaggtg tcgatggtgc   1301100
tgaacaaatc aaagcgatta tggctaaatt ccgcaacaat gctccaacag aatggaacgc   1301160
aacagctatc actgtcgtag aagacttcaa ggcacaaact gctactgttg ctgacggtac   1301220
tgttacaaac ttgacaactc ctccaagtga tgtgttgaaa tacacacttg ctgacggttc   1301280
atggattgcc gttcgccctt caggtacaga accaaaaatc aagttctaca ttgcagttgt   1301340
aggggaaacc aacgaagaat cacaagctaa gattgctaac atcgaagcag aaatcaatgc   1301400
atttgtaaaa taaagaccta taaaagatga gaccaaccaa cctcatcttt tttcgtatca   1301460
aatctaagca attttagaaa ctttatggca tactagactt atcaatgaaa gcgaggtaat   1301520
ctcatggaac aatttttaga taacatcaaa gaccttgaag tcactacagt tgtgcgtgcg   1301580
caagaagctc ttgataaaaa agaaactgca accttcttta tcggtcgcaa aacttgccct   1301640
tactgccgta aatttgcagg tacattgtca ggtgtcgtag ctgaaaccaa agctcacatt   1301700
tacttcatca atagtgaaga accaagccaa ctcaatgatt tgcaagcatt ccgctcacgc   1301760
tatggaatcc caactgtacc aggttttgtt catattacag atggacaaat caacgtccgt   1301820
tgcgactctt caatgtcagc acaagaaatc aaagatttcg caggattgta aaaaatcagc   1301880
taacaagtct taaaatcaca aaaacgcata atgtaaggtg caaaaacctt gatattatgc   1301940
gttttattgt tcctaaaaca gttacatcag tatttcatta cagaacattt taattttgga   1302000
agtcaaatca atttttaaca atgttttaga aatcacagtg ggctattcca tattcaatta   1302060
tccatattca atcgctatta tcgttttcct agattacaaa aaaaactacg ttttgctaat   1302120
caaaacgcag tttcagccac tattttatct tactgtcctt cttttacttc tttggttgct   1302180
acatcttctc caaaccattt ttggctgatt tcttggaact tgccgtcctt gtaaagacta   1302240
gaaaaagctt catttatctt cttaaccaag tttgtatctt ccttacgggc tccaaccgca   1302300
aaagcttctg tttctagtcc aactgtaaag acattataat cgtttaaaac accttctgct   1302360
tctaaataat agtttgcata gacacggtca atcaatagac catcaattcg atcgtttttc   1302420
aaatcaatca aggcttcatt aaaggtttgg tattgattcg cttccttatt agcgacaata   1302480
ttcttcaaaa tttctggatt tgcttcaaag tccgcataac cagatgaacc agcttgagct   1302540
cctaatgtct ttccagtcat atcctttgca gtcgtgatac cagatgattt cttcgtaacc   1302600
aatacctgct cattcttcat atatgagtta ctgaaagcca ccttttcacg gcgttcgtct   1302660
gtagcggaat agccattcca aatcagatca atcgttcctt ttgtcaattc agcttctttc   1302720
aaatcccaat caatcggttg ccaatttacc gtgattccgt atttttcaaa aacagctgta   1302780
gctaaatcaa tatcaaatcc tgcataagaa ccatctttct gagcaaatcc cattggaaca   1302840
aaagtactat caaatccaat agtaatagac ttgttagact ggtactttga ccaattatct   1302900
ccactagttt cgctagaatt tttcccacaa gctactaaga acaaagcagt catcagactg   1302960
actaatacaa gcatccattt tttcatccat ttttcctcct atttaggttc tactttcaat   1303020
aatacatctg cgatattttc agcaaactgc aaatcatggg taaccacaat ctgggtcatc   1303080
ccaagttccc tattttgcaa gattagcttc tccacttcca aacgtaattc tggatccagg   1303140
gcagaagttg gttcatcgta gccaatgatt tctgggtcaa tcatcatagc acgcgccaaa   1303200
gccacccgct gcttttgccc accagatagt gagaaaggat aggcctctgc gtgtcctcct   1303260
agtcctaact gttccaagag tccactcgcc ttcttctcag cctcttcctg cttcattccc   1303320
atggtcttca caggcgataa agtcaaattt tccagaactg atagatgagg aaatagttga   1303380
aaatcttgga agacaaatcc cagtagattg cgcttctgca attcatccag ctctaaaggt   1303440
tgtccattat aaaagatttg ccctgaatca atggtttcaa gacctgcaag catacgtaaa   1303500
agagttgtct tacctccacc agaaggtcca acgatagcca ggatttgctt ttcaggaata   1303560
cttagactga aattagacag gatttgtttg tctccaaaga ctttattgat atttcgtaat   1303620
tctaacatgg cagcctccta tctataataa ctatacttct tctcaacttt tttggaaata   1303680
attgtcacaa tcccaatcaa aatcaaataa atggctcctg ccaagaacat aggaactaga   1303740
ctagcatcgc ggttagcagc tgttcgacta gccaagataa ggtctgaaat tccgagagca   1303800
tagaccaaag aagtatcctt gaccaaactc ataacttcat taaagacact aggaagaacg   1303860
atcttggtca cttggggcaa gataatatag cgcactctgt caaaagggct aaacttcaag   1303920
accttggcgg cctcatactg tcctcttgga atagtgtcaa ttcccccacg gaaaatttct   1303980
gcaaagtaag ctgcatagtt gagaacaaag gcaataatag ctgcaggaag gcggtctaaa   1304040
cgaatcccaa tacttgggag cacataatag ataaaaatca gttgcaagag taagggggtt   1304100
cctcgcataa cccagatgta aatgttaatc agataatgga ggggcttcca atggacttgc   1304160
aaggcaaagg caatcaaaac gcccaaggga atcgaaaata gcaagaccag tgcaaagacc   1304220
tgtacagtcg tgctcgcacc attcagtaaa ctcggtaata tctcaaataa ataagacata   1304280
ctgcacctcc taaaagtaat tgttcctatt atagcatgaa taaacaagat taccaagtat   1304340
ttttgtaaaa agattctacc atatacaaat aaaaaccgta gctatcaaaa gagataaact   1304400
acagttctat atgtttaaac cccaattatt caccccaaat ctaaaaacca tccagaatcc   1304460
ttgccttagc ttagatcctg gatggtttct tttttcaccc aatgggtgtt ttttactaga   1304520
caaaaaagag tttccccttt atggtataag tgtagaaaaa aacacaaaaa gaaaggaaac   1304580
tcacatgaac agtttaccaa atcatcactt ccaaaacaag tctttttacc aactatcttt   1304640
cgatggaggt catttaaccc agtatggtgg tcttatcttt tttcaggaac ttttttccca   1304700
gttgaaacta aaagagcgga tttctaagta tttagtaacg aatgaccaac gccgctactg   1304760
tcgttattcg gattcagata tccttgtcca gttcctcttt caactgttaa caggttatgg   1304820
aacggactat gcttgtaaag aattgtcagc tgatgcctac tttccaaaat tgttggaagg   1304880
agggcagctt gcttcacagc caaccttatc ccgttttctt tccagaactg acgaggaaac   1304940
agtccatagt ttgcgatgcc tcaaccttga attggtcgaa ttctttttac agtttcacca   1305000
gctaaaccaa ctcattgtag atatcgattc tacccatttc acaacttatg gcaagcaaga   1305060
aggtgttgct tataacgccc actatcgtgc tcatggctat catcctcttt atgctttcga   1305120
ggggaagaca ggttattgtt tcaatgccca gcttcgtcct ggtaatcgtt attgttctga   1305180
agaggcagac agctttatca cacctgtttt agaacggttt aatcaacttc tctttcgaat   1305240
ggatagtggc tttgcgaccc caaaattata cgatttaatt gaaaaaacag ggcaatacta   1305300
cctcataaaa ctcaagaaaa atactgttct gagccgtctt ggagaccttt ccctcccttg   1305360
cccacaggat gaggacttaa ccatcttgcc ccactccgcc tactcagaaa ctctctatca   1305420
agcaggatct tggtcgcaca agcgtcgtgt ctgccagttc tctgaacgaa aagaaggaaa   1305480
cttgttctac gatgttattt ctctcgttac aaatatgacg agtggaacaa gccaagacca   1305540
gtttcagctt tatcgtggac gtggtcaagc cgagaatttc atcaaggaga tgaaggaggg   1305600
attttttggc gataaaacgg atagttcaac cttaatcaaa aacgaagttc gtatgatgat   1305660
gagctgtatc gcctacaatc tctatctttt tctcaaacat ctagctggag gtgacttcca   1305720
aactttaaca atcaaacgct tccgccatct ttttcttcac gtggtgggaa aatgtgttcg   1305780
aacaggacgc aagcagctcc tcaaattgtc tagtctctat gcctattccg aattgttttc   1305840
agcactttat tctaggatta gaaaagtcaa cctgaatctt cctgttcctt atgaaccacc   1305900
tagaagaaaa gcgtcgttaa tgatgcatta aagaacagtc gagatgaaaa aatcgtgtga   1305960
cgcaccaagg gaggagtctg cccttttgag gaaatctagc gaggaaaaac gatactggaa   1306020
cagcagaaag taaaactgac ctcatgagga ggaagaaagt ggctcatgag gtcaggggtt   1306080
ttgtaagtta catctagttg agagaggtat gaatgatttg ggttaaacat tcttacaatc   1306140
tctcaaacag ttcttgcatt tgcacatcat ctggaaccag ttttaagtaa gtgtgagcat   1306200
ggacttttgc ttcttcaaaa tgtcccaatt cacgcaagag atagatatag tgttccagaa   1306260
attctggatt gtccttcaaa tctcctgtca actcttgata atactcataa gcagtatcca   1306320
aatcgtccat ttcttgataa gaacgagcaa tcatccactt ggtcaaaaga ttttctggct   1306380
cctcactctg caattctaga atatcctcat aacgctcctg ctccagataa atagtggcta   1306440
aacgaagcaa gatttcttct gtatcctcag cgtcttcttt tgcagtaagg agataatttt   1306500
ctgcaccact agcatcatgc aattcataag aaaattgtga agcagctagc aagaggcgag   1306560
tttcaaaggg atttttctct aatccttgct tagcgatacg cagggcttct tgaacttgat   1306620
gttccttatg taaagcctga ctgtacccat actcatagcc ttcaaagtca ggagaaatgg   1306680
tatcaagctg cttaaagtag agggtggctt tttgatattc ttcttgatca aaataaagac   1306740
tggccaactc aaaagctgtt aagtcatcgt attctaactc cagggctttt tctaaaaact   1306800
cagtagccgt ttcaaatttc cctaactgag cataggcaaa gccaattcgt tgataggtgg   1306860
aaatgcccgt ttgctcataa atcgagcgat tatctaactg ggcataggct tgaatagccg   1306920
cttggtaatt ttccaactca ctatccaact ctgccaaacc caatatcaag agagaatcct   1306980
ctgagtaggt caaggcctcc aataatttct cacgtgccac atctgtcaaa ccttccagct   1307040
ggtaaaggtc tgccttcaga gccaaagacg agacatacca gtcactgtca gcttggattt   1307100
cctcaagata ggtaaaggct tcttctattt gaccatcctc gctagcaatt gcagctagat   1307160
taagatgaac ctctggaaaa tcctctacaa ttttcaggta aatttccttg gcctgaggat   1307220
agaaaccaat cccttcaaga taagttgcca attcatacag aagatcactt gaatcatttt   1307280
ctaaagcttt ggcgaaataa tgctcagcct tagttaaatc ttgctcctcc aaagcctgta   1307340
acatctgttg actattgttc actcttgact tcctcaccct ctaattcata tagaccactg   1307400
actaccttat accattcgaa aatggctgaa atgacaacct tagcagaggc ataaaccgga   1307460
ataccaagta aaactcccca gataccaaac atagatcctg aagttaacaa aacaaagaga   1307520
acattaatag ggtggatgtt taattgactt cccaaaatca atggagagac aaaacggcct   1307580
tcaatagttt gttctacgat aaagacaatc actactttca aaagcatgac tggaccagca   1307640
atcaaaccca atactagagc aggaagcatg gctagaaagc taccaagata agggaccaga   1307700
tttaaaatac cagcagtaac ccccagcgta accgcatagc gtagaccaat aatcttgaag   1307760
aagatgataa acattactgc tacaataata gccactgtca cttgccctcg aacatagttg   1307820
gacaactgtt gattcacatc tgataaaact tgtccaacag gttccttcaa ttttcttgga   1307880
atgaattggg tcaaatagtt acgcaagcct ttcccatcac gcaagagata aaagagcatg   1307940
aaaggaacga taatcaaggc aacaatcact tgagaagccc cgctaataaa ggcactcacc   1308000
cagttgactg cctgagatga aaccttactt gccaaaactg tagcctggct agaaaaattg   1308060
gtcaaaactt gctctaattg aggtctgaaa tcatctggca ggtgctgggc taccaatcca   1308120
ttaacaatcc tatctatatc ttctaagtaa acaggaacgt ttcttgcaaa ggtcaaaacc   1308180
tgacgttgca gatttggaat ggcgactgcc aagccccaaa tgataaagag agcgatgata   1308240
acaaagacaa tagtgatagc tataacacga ttaaccttat gcttctccat ccaatcaaca   1308300
ataggattca acaaataata taacaaacca gacaaaatga ctggcaacat cacaactgct   1308360
aaaaagtcta aaacaggtga aaatagaaaa ctaatcttac ttaaaataaa aagattcagt   1308420
cccaataata aggttactaa aaataccgta attgccttgt tatctaaaaa ccacttgaaa   1308480
aaccaagata ggctaaaatg tttctctttt tgctccataa atacttcctt tctattgttc   1308540
tctcattata ccatttttga aacaaaataa ctctttttta aagtgcttac atctaattgg   1308600
atatctttaa tttacttgtt tttgtgatat aatagtctta tctttacaca gaggtatagt   1308660
aatgaaagaa actgtttatt ttggaactta tacacgtcgt acttctcaag ggatttacaa   1308720
ggcagacttt gatacagaaa ctggtcagct ttcaaatcta gaactttttg cagctgagcc   1308780
aagtccaacc taccttgcct ttgaccagca ccaacattta tacactgttg gtagccaaga   1308840
cgataagggg ggaattgcag cctatcaaac tgacgggact gtgttaaatc atgttgttga   1308900
agaaggagct ccccactgtt atgttgctgt cgatgaaaag cgtgatttgg tttacgcagc   1308960
taactatcac aagggacaag tccttgttta taaacgccag gaagatggta gtcttctact   1309020
tagtgatatg gatcaacaca gtggccaagg tccacatgaa aatcaagctt ccccccatgt   1309080
tcactataca gatttaacac ctgaccacta tctagtgacc tgcgacttgg gaactgacca   1309140
agtcatcacc tatgacctcg atcaagaagg aaaattatct aagctctata cctatcacag   1309200
caagccagga gcaggctcac gccatatcat tttccataac cactataaaa tcgcttatct   1309260
catttgtgaa ctcaatagta ctatcgaagt tttaatctac gatggcgttg gcgaatttga   1309320
acgtatgcag gtcatttcaa ctttaccgga agcttacgaa ggctttaatg gaaccgctgc   1309380
tattcatctc tctaaagacg gtaaatacct ctacgcttct aaccgtggcc atgattctat   1309440
cgcagtatat accatccttg cggacggtag cttagagtta ttagaaatcg ttccaacgca   1309500
tggtcagact ccacgtgatt ttgatttgac acccgaccaa aaatttctca ttgttgtcca   1309560
tcaagactct gacaatgcaa ctgtctttaa acgtaattgt gacaatggtc gtctagcaga   1309620
actctccaac gacttccatg ttcccgaagc agtctgcatc cgttttgctc cttaaaacac   1309680
cataaaaaat gaacttggta ttttcaagtt cattttttct tatagtctat ttccgacatt   1309740
aatacggtta atagcacgtt gcaaagcaat cttagcacga cgttcttggt caatcaaatg   1309800
tttgtcttgt gcttcttcaa ttgcacgttc tgcacgaagt ttggcacgtt ctgcacgact   1309860
gatatcgata tcacgagcac gttctgcaga gtcagcgacg attgtgatca tatcattggc   1309920
aatttcaata acgccaccgt ttactgcaat ccagttcacg tgatctttat catcgatacg   1309980
ttttaccttt acttcatcaa ctgctaaaac cgcaatcata ttttcatgtc gtggcaagat   1310040
ccccatctca ccatccagag ttcgaaccga tacatagctg gcatggtgat catagacgag   1310100
accatctggt gtcacgatct ggacagttaa ctgagccata gatcacctct taaaatccca   1310160
ttttttcagc ttttgcaatc acatcttcga tagaacctac accacggaag gcatcttctg   1310220
gcaagtggtc gtatttacca tcaaggattt ccttaaagcc acgtacagtt tcagcaactg   1310280
gaacataaga acctggctga ccagtaaatt gttccgcaac gttgaagttt tgtgacaaga   1310340
agaactggat acgacgggcg cgagcaacca aggtcttttc ttcatcagaa agctcatcca   1310400
taccaaggat agcaatgata tcttgcaatt catggtaacg ttgaaggaca cgttttactt   1310460
cagcagcaac tgcatagtgc tcttctccaa cgatttcagg tgccaaggca cgtgagcttg   1310520
aagcaagtgg gtcaacggct gggtagatac ccaattgtac caacttacgt tccaagtttg   1310580
ttgttgaatc caagtgagcg aaggctgttg ctggcgctgg gtcagtatag tcatccgctg   1310640
gcacatagat agcctggata gaggttacag aacccttctt ggttgatgtg atacgttctt   1310700
gcaattgacc catttccgta gcaagtgttg gttggtaacc aacggctgat ggcatacgac   1310760
ccaaaagggc agatacttct gaaccagcct gagtgaaacg gaagatatta tcgataaaga   1310820
gaagcacgtc ttggccttcc acatcacgga agtattcagc gattgtcaaa ccagtaaggg   1310880
caacacgcat acgtgctcct ggtggctcat tcatctgacc aaagaccatg gctgttttct   1310940
cgataacgcc tgattctttc atttcccagt aaaggtcatt cccctcacga gtacgttccc   1311000
caacaccagc aaatactgaa ataccaccgt gctcttgggc aatgttgtga atcaattctt   1311060
ggattaagac agttttacca actccggcac caccgaaaag tccaacttta ccacctttaa   1311120
ggtaaggggc aagaaggtca ataaccttga tccctgtttc aaggatttca gaagaggtag   1311180
acaactcatc aaaagttgga gcttttttat gaattggctg acgctctgcg tcttctgtaa   1311240
aaggagcttc caagtcaatg gtatctccca aaacgttgaa gacacgtccc aaagtttctt   1311300
tacctactgg tacagagatt ggacgacctg tgtccaatac ttccattcca cgagtcaacc   1311360
catctgttga ttccatggcg atagtacgaa ccataccatc tcctaactcc aaggctactt   1311420
caaggacgat ttttgttttt ctttcgtcat ttttgtagac gacaagtgca ttgttaatct   1311480
caggaagttt ttcccctgct gcaaacaaaa cgtctacaac gggaccgata acctgagcaa   1311540
ttttacctga actcatctcc ttctcctatt ctatataaga tactgtcggt tcctagctca   1311600
actaggtcct aagttcattt tcatacgagc tggactagag cctattctaa ggcactagca   1311660
cctgctacga tttctgtaat ttcttgtgta atcgccgcct gtctggcacg gttatactga   1311720
attgtcaaat cattgatgac tttcttagca ttatctgtcg ctgtttgcat ggctgtcatg   1311780
cccgcagcat tctcagctgt cttggcatcg ataatggcac cgtaaatcat actttctgca   1311840
aactgaggca acaactgctc cagaatttct tctcggctgg tttccaattc aaaagtcaag   1311900
ctgtactctt catccgcttc atttggatcc aagtcaacaa tcggaagcat ttgttccaca   1311960
cgcatttgac tggttagcgt attgacatgg tggttgtagc aaacataaag ctcatcaaag   1312020
agttcatttt ggtacatttc aacagttttt gaaataatct tacgaacttg atcaaagcta   1312080
ggttggtctg acaagccacg taattcataa agtggttgaa taccgcgagc cttaaagaaa   1312140
tcagctccca tcccaccgat acagatcatt tcaaaacctt taccgtctgg gtggtattct   1312200
tctttcaact ccataacagc tttcaaaata gaggaattat aacctccaac caaaccgcgg   1312260
tctgaagtga taacgatata gcctgtcttc ttcacagaac ggctaatcaa catcggatta   1312320
gttgaagcac cagctccatt accatgaagg atatctgtca aaagtttacg cactttctga   1312380
gcgtaaactt ggaagttgcg agcagcttct tcagaacgac ctagcttagc agccgatacc   1312440
atttgcatgg cattagtgat ttgactcgta ttttttgttg aggcgatttt tgttttaata   1312500
tcatttagag atactgccat ctgacacctc tattcttatt ggaagctaga ttgattgaga   1312560
aactctgtaa tcgcagcatc caagactgct tcttctggca agtcttttgt atcacgaatg   1312620
gtttccaaaa tctctggatg ttgagcatca aagaaggcat ggaactcttc ctcgaaacga   1312680
acaatatcat ctactggaac agtatccaag aaaccatgtg tcaaagcata aagaatggtt   1312740
acttgtttct caacaggtaa tggtttgtga acaggttgtt tcaagacctc aacggtacga   1312800
cgtccacggt tcaacttagc ctgtgttgct gcgtccaagt cagaaccaaa cttagtaaag   1312860
gcttccaact cacggtatga agcaaggtcg atacgaagtg taccagcaac cttcttcatg   1312920
gctttgattt gtgcagaacc acctacacga gatacagatg aacccgcatc gatggctgga   1312980
cgaatacctg cattgaagag gccatcgcca aggaagattt gtccatcagt gatagaaatc   1313040
acgttggttg cgatataggc tgagatatct cctgcttgtg tctcgataaa tggtagggct   1313100
gtaattgatc caccaccaag ttcatcagaa actttagctg agcgctcaag caaacggctg   1313160
tggagataga aaacatcccc tgggaaggct tcacgacctg gaggacgacg aagcaagagc   1313220
gacagttcac gataagctac cgcttgtttt gatagatcat cgtatacaat caaaacatgc   1313280
ttaccttgat acataaattc ttccgccata gcaaccccag cataaggagc taggaagagc   1313340
aatggagatg gttgtgaagc agaggctgtc acaacgattg tgtagtccaa ggcaccgtac   1313400
tgacgaagtg tttctacttg cgtacgaact gttgattctt tttgtccaat cgcgacgtag   1313460
atacagatca tatcttgatc tttttggttc aagattgtat caatcgcaat ggttgttttc   1313520
cctgtctgac ggtcaccgat aatcaactca cgttgaccac gaccaatcgg tacaagggcg   1313580
tcaatagctt tcaaaccagt ttgcaatggt tctgaaacag acttacgttg cataacacca   1313640
ggagctggtg cttctactgg acgagtttta tcagtgtgga tttctccaag accgtcaact   1313700
ggacgaccaa gcggatccac aacacgacca atcagacttt cacctacagg gacttccatg   1313760
attttccctg tacggcggat tgtatcgcct tcacggatat ctgtaaagtc acctaggatg   1313820
ataataccaa cgtctgttga ctccaagttt tgagccatac cataagagcc gttttcaaaa   1313880
ttcaacaact ctccactcat gacattttca aggccgtgag cacgcgcgat accgtccccg   1313940
atataggtta caacacctgt ttcagtcaca tcaaaattgg gtttgaaatt ttcaatttgt   1314000
tgcttaatta aagcgctgat ttcttgtgcg ttaattgcca aaagaacacc actttctatt   1314060
tcaaattttc tttaacaact ttaagttgtt gtttaatact cacatcaatt gtcttgtgat   1314120
tggcaaaaat gacaaaacca ccaatgagac tttcatcgat ttgttctttt acactcctta   1314180
ctttcagaga catttttttc tcaatcaaag ggagcaaacg agtcttctgt tcatcagtta   1314240
gaggatgagc agacgtaatc gtcacttcaa atcgatttgt ttctttttca agtcggttca   1314300
agcaatctac aagcacatca taaaaaagat ttgctctgtg attgtaggcc agaacctgga   1314360
taaagttttg taataaaggc gacacagaat cttggaaaaa agcaattgtt ttttccttat   1314420
ccgactcgtc tactgccact tgttttaaaa aagaaggcag acctgttttt tcaacaactt   1314480
gcttgatttg agtcaagtct gaaaagatac ggtcttcttc tcctttttca agtaccaatt   1314540
ggacaaaagg catgctgtat ttttcaatta cctttactgt tttcttgtcc attaagcttc   1314600
tcctagctga tcgatatact gatcaatgag tgctttatgg gcatgactgt caaggttttg   1314660
tgagatgatt ttaccagcta agctgatggt caaatctgcg acctcaccct taacactctg   1314720
taaagcttct actttatttt gagcaatttc ttgattggct ttttctttta agtgtcctgc   1314780
ttctagttta gcatctgcta agatattagc cttactttgc tcagctgttt cctttgcatt   1314840
ttcaatgatt gtcttagctt ctttacggct accagccaat tcatcttcgc gtttttgagc   1314900
caatacttct gctttttgac gggcttcttc agctctgtca atatctgaag caattttttc   1314960
agctctttct tcgaaaatgc ctgtaatatt agaccatgca aattttttaa tcaagactag   1315020
caaaagaata aaagagccag tgattaaaat aaaattacca attaattcac ctactgttac   1315080
gtgcatcagt tactcctttc tattcctctt caatattaat cttattccct aaatacacag   1315140
atgtcaaaag agtaaaaaca taagcttgga tgcaggaaat aaagacagaa aatgcagtcc   1315200
aagccaaatt agctccaaag gctactggat accaataaat agcttggtgg gaaagaagaa   1315260
gtaacaaact cgtcatgacc tctcctgcaa agatattccc aaaaatccgc aaagccaaag   1315320
ataagaagtt tgtaaattct tccaagatat tcatcggtat gacaaaaaca ggactcataa   1315380
aagattttat acttttttta aatccacgac gacgaacgct ttctatatgt gtcaacaaaa   1315440
tgacaagaaa agataaggtt aagtcatact gtaaattagc ggttggcgaa ctccaccagt   1315500
tagtcccatc gatcgtttga agctttgtca ttaagccaag gttattggca atcaccatga   1315560
aaaggaataa acaaaggaaa aagagtgagt aatctttcat gtagcgcgaa ccaatgttag   1315620
gttctgtaaa tccaataaca aagtcataga catactcaag tacattttgc tttcctttgg   1315680
gtttcaaggt catattgcgg cttgcccaat aaataaagac aaaaataact cccacaatca   1315740
acaaagtcat ggctaacata gtcagattga agataacagg accaatagag atgattggat   1315800
taatactttc ttccatctaa aatcctccct tttcttctcg ttccatgtat ttatttgata   1315860
ataaatgaga agacaagagt tacaaagaaa gttccttcaa taaaggcaac acctaaaaac   1315920
atcaaactac gaaactcaga aagcatatct ggttggcgtg ctactgattt aaacagtcca   1315980
ttcatcaata aaccttcacc gacagatacg cccatacagg caatacataa gcctaaaaat   1316040
gttaaattca taacaaattc tcctttaaaa taaaatttac ttacttagtg tagtcctaaa   1316100
atttaaattt gtcaactttt aaccgctatt ggaagcgttt aataaaaatt atttccattt   1316160
tgctaaattt caagttcaag ttagccatcc agaagtcttc tctgggtgac ttgtagtcca   1316220
agcatttttt aggatagttg ttaatccact tttcgatgaa tgcgacttct ttgggagtca   1316280
ttttcttggt tcccttaggt aactatctac gaatgagcct gttgtgattc tcattagttc   1316340
ccctttccca agaggcatag gggtgcgcat aatagatgtg ctcctcagaa aatatatcaa   1316400
acaagcgatt gaattccgtt ccattatctg ccgtgatgga aagaatcttg tgttgtttta   1316460
agatgagttt tagagcctga ttgaccacct cagcactttt atttggaatc aatcggatga   1316520
tctgatgtct actctttcga tccgtcaaga caatcaagca gtagtttttc gatctcgtaa   1316580
gtagaaccgt atcaatctca taatgcccat tctccaagcg aagattgata gcttcaggcc   1316640
gctgttcgat ggattgacca gcaggtttaa agttggtgct agcctgtttc ttaagcgctt   1316700
ttccttttct agggtaaagc aaatcctgct tgcttaaccc caattttcca tgatgaatcc   1316760
aatagtaaat ggttgaaatt cccacgttaa cccctttagc cataaccatc atttcaggcg   1316820
aaaatttttg gttatgatag tggagaatct tttcctttag ttccttggtc aagcttgatt   1316880
tcttgaccga gcgcttgcga ttgttttcat aagactgttg agcgtagtcg gcagaataaa   1316940
cctctttgaa gcgccctttt ccaagacatt gtcggactgt cccacgcttg atttcagtgt   1317000
gatagtttga ggagcttttc caagtagaga ggcaatttct ctatttgatt ttccttcttt   1317060
tttccatctt tcgattaagc gacggctatc gattgtcaaa tgtttggctt ttgtagtata   1317120
attgtcttgc atctctgtgc ctttcttgtg tttgtggttg aacaacaagt ataacacaga   1317180
ggtgctttct tatgcctaca agagctttca ttatttccat tttcttttgg atttcactct   1317240
attctgaaaa acttgtgtat atttactgaa gctagcaagt cttacctgta aatttaatga   1317300
aagcaacaca aaatccgaga ggggaatctc ggattaatag atagagagtt tttagtttaa   1317360
ataaattgtt taaaatatca acaacatcac ttcttttctt aacctgataa gtcttgattc   1317420
ctaattttgg ggctacgatt atattgtcct caatatcgtc tagaaagaca caatttctag   1317480
gttataactg gtatttatcg atagttactc atatacatca gtccacctcc atacttatgt   1317540
gcgagcctct ctttgtatta tacctccata ctcaccttac agattctttt ggtaataata   1317600
tctttgccta atgtagagac agtcttgcaa agaaaaaact tccttgtagc catgtttctg   1317660
ataaaagtcc ggtgcctgga actggtaagt attgacaaag gcaaaacaac aatttcgatt   1317720
cttagcttca ctttctgcct gttgcaatag ttttgaaccg attccttgcc ctcgcagttc   1317780
ctcttttaca aacaaatact cgatttctag ccaatttcca aaagtctctg ctatcaaacc   1317840
tgccaggaga ttgccctttt catcttcgac ataaagatta agtggctcac tttcagcctc   1317900
ttctcttttt gaacggttat aaacacgaat cagattccct atttcttgcg atttatgtga   1317960
ttccttattt tccaatctaa agtatagtga aatgaaataa aacatgcgca aatcgattaa   1318020
ggaatttaat ctaatttcta acaatgtctt agaaatcaaa gtgtactatt ttaacttcaa   1318080
tgcactatac atctaatact caataaaaat caaagagcaa actaggaaac tagccgcagg   1318140
ttgctcaaaa cactgttttg aggttgtaga tagaactgac gaagtcagct caaaacatag   1318200
ttttgaggtt gtagatgaaa ctgacgaagt cggctcaaaa catggttttg aggttgtaga   1318260
tgaaactgac gaagtcagct caaaacatag ttttgaggtt gtagatgaaa ctgacgaagt   1318320
tagctcaaaa cactgttttg aggttgtaga tgaaactgac aaagtcagta accatacata   1318380
cggcaaggcg acgctgacgt ggtttgaaga gattttcgaa gagtagcaaa atggaaaaag   1318440
gagtgagtga agcacatcgc ctccccactc ctttttctgt ttttaggctg ttttttcaac   1318500
cttcaagatt tttacatcat agctaccaac aggcgtttca atggttgctg tatcacctgt   1318560
tttcttgcca atcaaggcct gcccaattgg gctttcattt gaaaccttac ctacaaaggc   1318620
atctgcacca gctgaaccta cgataatata aacttcttct tcgtcctcac caatttcttg   1318680
gatggtgact gttttaccaa tcgctacttc gtcctgggca actgcgtcgc tattgacgat   1318740
ttcagcatag cggatttttg tttctaagct agagatttgt ccttcgacaa aggcttgttc   1318800
atccttagct gcttcgtact cactgttttc tgaaaggtca ccgtatgaac gggcaatctt   1318860
aatgcgttct accacttctg gtcgacgaac caatttcaat tcttctaatt ctttttcaag   1318920
tttttccttt tcctcaaggg tcataggata tgttttttct gccatttttc tcaactttct   1318980
tctgataata ttttctaaag aaaattatgt gaagtatcac ataattttag tttgtttagt   1319040
ttaatttgct gttgacatgt tcagcgacat tgcggtcgtg gtcttcttga ttgttagcat   1319100
agtagacctt gccttctgtg acatctgcta caaagtagag gttatcgctc ttagtttgat   1319160
tgatgcttga ctcaatcgca tccagacttg gactatcgac tggaccaggc atgagaccta   1319220
catttttata aacattataa ggtgaatcaa tgttggtatc aatcgcaaca tcctcagcta   1319280
gactgatatt ttgccccagt tttccttggg catacaagat tgcaatatta ctttgaagtg   1319340
gcatatcacg attcaaacga ttgtagaata cacctgcaat gagcttacga tcttctgtct   1319400
tggcaccttc tttttcgacc aaggaagcaa tggtcaacaa ctcattgaca gtcaagtttt   1319460
tagatttgat agtactatag taaggagata ggttcttatc catagcagct aacatctcat   1319520
caatcaagct ctcaatagtt gtgctttcct tgatagagta tgtagctggg aaaaggtatc   1319580
cttccaaacg ataacgcgca ccgctgtctt ttacaggcaa actttccagt aaagtaggat   1319640
atttcgctac tgcttgactg ataaacgtct catcttgaac tttagccaag aaagcctccg   1319700
ctgtcaaaga ctctttgaag tcaccttgca attgacccac agcttgagca atctgatcca   1319760
aggtataacc ttctggaatt gtcaaagtcg caagtacagg ttcttgcggt tcatctgttc   1319820
cacctttttg caactctttg agtaagtctt ctgtactcat actcttttgc aaattgtagt   1319880
aacctgcttt caagtcggta taatttttat acttggcata aaaactaaaa atcagaccat   1319940
gctttaccaa accagctttt tcaagcgtcg taccgatttc ttgaacgttt gaaccttctg   1320000
gaattccaac cgtcacatat ttcttagaat tagcatcgat aggtaataag gaatctagca   1320060
cgtactggta accaaagtaa ccacctgctg agagcaaggc aaggaataca aggaatgaaa   1320120
tcacaaaagc tttcacatgt gacttcttct ctttcttagg cttaacgggt tttgctcctt   1320180
ctctacggct acgacgtgat gtatctctga tgatatccac tgtttctgta gcaggcgtag   1320240
gtgtttctgg acctgcttgt tctgcttttt tctctgccgt cgtataggaa acagctaccc   1320300
ttgttggggt ttcattgtat tctctttcaa gtttcttagg tctaacagga cctggacctg   1320360
gtcttgatcc actttcttcc gctggagaag aaggtacatc ttgacttgga tgacttggaa   1320420
caccaggagt ttctctttga atctcatctg ctggagaagc tggtacacct tgacttgggt   1320480
gagtaggcac ggtaggagct tttctcataa tctcctctac cgttgacaag gaatcagcca   1320540
tgagttcttc agttgaaggt tcatttgcag gagtgcgaac tactgcctca tcttctttca   1320600
gaacttcatc atagcctttt actttttcta aatctctcag aatctgctct ttaaagctta   1320660
atttctcttc ttctcttgac ttttcactca aaagtttttc ctccttgttg ataatccata   1320720
atattatatc ttaaaagtcc aaaaaaagca atctatgata cttttcctaa cttatttttt   1320780
catttcccag accatatcat accatgtttc ccctgcaaag gttgactggg actggccttc   1320840
gttgacaaat ccatgttttt catagtaggc gatgagatag tcatgacagg ttagattaat   1320900
gccatctctc tcatcttcaa gagcaacttc tttcaaggct gtcagcaatt tctggcccag   1320960
tccgagtccc tgtgcctcct tggcaataga cagacaggtc acagagatat aaccaccagg   1321020
ctcatgacta tagtctttta tttcttctgt aaaagactgg tcttgcagat ggcggtgcag   1321080
gccaactggt ccttcgatat aacccatgat tcttccttct ttttcagcaa ccagaaaaga   1321140
ggtctgaatt tctctcaaat gtgcttcaaa gacagaagga ggaatggctt cttcgaccga   1321200
aaaattttca aattcaagtt caacaatccg atccaaatct tctaatcttg cttgtctgat   1321260
tttcattgtt cctccagata aaagggatta aaccaaatca tactatagcc ctggctagtt   1321320
gcatagagca aagttgcttc ttcatcaaca aaaccgttca tttcaaaata ggaaagcagc   1321380
tcatcaggac tctccaaacg aatccctttg taatccagct caactgccac ctctttcaag   1321440
gctgcaagaa gaagtgttcc caggccctgt ctctgatggt caaactcgat gactaaagaa   1321500
tgtactttta gacattgcgg attgtctgac tggggacttg ataaaatata gcctaaaagt   1321560
tgattttcat ccctagctag aagaaaggta tccgcacact tacggatact ttcttctaaa   1321620
atatgggaaa gttgctgctt ttcagctgga aaagacgagg tctgaagtgc ccctatctca   1321680
ggcaaatcag acttgcttgc ctgaatgatc ttaattggaa tttccatggg aacatcctat   1321740
tgaacattgc ttgtcaagtt agacaagaga cgctcaaatg agtattcata ggtttggatg   1321800
tctcctgctc ccataaagac gtaaacagca ttgtcatggt ctaggagtgg agaaacattt   1321860
tcaacagtaa tcacttggtg ttttttgttg attttgttgg ctaggtcttc taccttaacg   1321920
tcaccatgat ctacttcacg agccgagcca taaatttgcg ctagataaac agcatctgct   1321980
tggtttaaag catgggcaaa gtcgtccaac aaggcaatgg ttcttgtaaa ggtatgcggt   1322040
tgaaagactg ctacaatttc cttgcttggg tatttctgac gagccgcatc caaggtcgca   1322100
ataatttctg ttggatggtg ggcaaagtca tcgataatca ctgtatcatt gacaattttc   1322160
tcagtgaaac gacgtttaac accggcaaat gttttcaagt gctcacgcac caagttcaaa   1322220
tcaaatcctg ctgtgtaaag aagaccaata acggctgtcg cattcatgat attgtgacga   1322280
ccaaaggttg gaatgtggaa ttgccccaag ttttgtccac ggaaatgaac ggtgaaggtt   1322340
gaaccagtta ttgaacgaag aagatcacta gctacaaagt cattgccttc agcttcaaaa   1322400
ccataataat aaattggtgc atcagacgta atcttacgca attcagcatc ttcaccatag   1322460
acaaaaagac ccttggtgat ttgtttggca tagtcgttaa aggcattaaa aacatcctcg   1322520
agacttgtga aataatctgg atggtcaaag tcaatgttgg tgataataga gtattctggg   1322580
tggtaaggca tgaagtgacg ctcatattcg tcagattcaa agacaaaata tttggcattg   1322640
gccgaaccac gacctgtccc atctccaatc aagaagctgg tatctgtaat gtgagacaag   1322700
acatgagaca acatacctgt cgttgaagtt tttccatgtg ctcctgctac tcccatgcta   1322760
acaaagtcac gcataaagct acctagaaac tcatggtaac gtttgtagct gataccattt   1322820
tggtccgcat aggcaatttc gacgttgtta tctggacgaa aggcatttcc agcgataatt   1322880
tccatatcac cgtctagatt tttttcatca aaaggaagaa tggtaattcc tgcctgctca   1322940
agaccgcgtt gggtaaagta gtacttttca acatctgatc cctgaacctt gtgccccatc   1323000
tggtgcaaca tcaaggccaa ggcactcatc cctgatccct taattccgat aaaatgatat   1323060
gtctttgaca tgttttctcc cctattctgt cattctggtc agattcaact cttgggcaac   1323120
ccgacgttct tgttctgttt gtttactttt tttattgtag atttggctct tctttagaaa   1323180
atcataattg tttttctttg gagcaggtgc tgacacttct tcattcttgg tagggataga   1323240
atgaacttct tccgccaaga tataatgaga ctgggtcaat ttttggctat atttgacaaa   1323300
ttcaccagga ttttcctttt ggaaaggagc tgtcggttga ttgccctgtc taactagact   1323360
gggctgagaa tgacgtctcg caaggctgaa atcctgagtt aggtagttag cagagcgttt   1323420
ctttttcaag tccgcacgcg cttcttcacg cgccacctcc gcatagctct ttccttcttt   1323480
tttaacccct aaaggagcct ttttaggttt ttcgacttgc ttttcaatcg gttttactgg   1323540
tttttcttca gcaataggag cccattctaa ataattttta tctcgatact cacccttgat   1323600
attactgatc agatcagact catcatagag attcatgact ggcatttcag tcaacatgac   1323660
ctcgtcatct gacaccaatg gaaatcgttc ttgtttcatt ttctatttcc tttcaacact   1323720
tcattatagc gtattgtctt gatttttcaa gtgctggctt cagaaattcc caaaatttct   1323780
ctaatttctg ctagggtcag actaccacgt gactctgtgc cgtccaatac ttgtgacacc   1323840
agatgtttct tttgttcttg gagttcctga attttttctt caatggttcc cttggtcacc   1323900
aagcgataga cctcaaccgt ttcttcctga cccatccgat gggcacggcc aatggcttgc   1323960
gcttccaccg caggattcca ccaaaggtca accaagatca ctgtatctgc acctgtcagg   1324020
ttcagaccga ccccaccagc cttgagggaa atcagaaagg catctctttc tccttggtta   1324080
aaggccttgg tcatgtcttg tctttccttg gctggggttg aacccgtaat tttaaaggaa   1324140
gtcaggccca agtctggcag ttcttgttca attttttcca acattccctt gaactgagag   1324200
aaaatcaaga cacggtgtcc gccgtctgcc acctgtacca gtaggtctcg gagactatct   1324260
agtttgccgc tggctccctg ataatcttcc ataaacaggg caggagtgtc acatatttga   1324320
cgcaagcgca tcaaaccaga taaaatttcc acacgacttc gctgaaattc ctgttctgac   1324380
acttgagcca gatggtctcg catctgttgt aactgggcaa ggtaaatagc cttttgctgg   1324440
tcttccagtt catttttata aaccacctca atcaagtctg gcaattcagt cagaacttct   1324500
tctttcttgc gtcgcatcac gaaaggcttg ataaactgag ccactcgctc tgctggcaat   1324560
ttcataaatt ctttcttgct tggcaaaagt ccaggcatga cgatttggaa aatagaccac   1324620
aactcaccca gatggttttc aatcggagtt cctgacaagg caaagaccga cggcaccaca   1324680
aattgtctca aggtctgggc aatcttggtc tgggcatttt tcatgacctg agcctcatct   1324740
aagaaaagga agtcaaaggc catcccttga taaaactcac tgtcctgacg gaaggtggca   1324800
tagctagtca catagatttg atggctctcg gcaagaatct cctcacgact tgctttcaaa   1324860
ccatgaacaa cagtcacatc caactgtgga gcaaatttct gaaactcatc tgcccagttg   1324920
taaatcaaac ccgacggagc gagaatcaaa acccgacttt cttttgtcac ttgactagtc   1324980
aaaaaagcaa tggtctgaag ggttttccca agtcccatat catcagccaa aatcccacca   1325040
aaaccataat gatggagcat ctgcaaccag ccaattccct tttcctgata atctcgcaag   1325100
tcagccttga cctgagttgc ttgcaaagga aagtcctctg gatgcgtcaa atcctgggcc   1325160
agattctgga attcttgtga aaaagaaaca cggtctcgcc cttcaaagag atgagctaaa   1325220
ctgtaggcca aggatttccg agcctgcaag gtcccatctt ttaattcaaa ttgccccagt   1325280
tcctgtagat tttggcgaat tttcttggtt tcttcatcga aaaagtaaac ttgattagac   1325340
gaatcaatat aaaaatcctg attggcaacc aaggcctgca tggcttggtc gatttcctcc   1325400
tggacaatat tttgaaaatc aaactggatt tccaagagac ctcccttgga ggcaatctgc   1325460
acctgaggac tcgctaggct ataaagctct tctagtttat ctgataggtc aacatgcccg   1325520
agtttttcaa agactggaat gatatcatga aaaaaatgat agacagactc cgcttttaag   1325580
gcctgacgcc aagattgaaa atcggcctca aagcccgcag ccaaacagac ttggaaaatt   1325640
ctttcttcta agtctgcgtc acttgaaaag ggtaattctt ctagctcttg tcggctagat   1325700
acctgtctat ttccataatc aaactgaatt tctaaacgaa tccgattatc ttcttccctg   1325760
tcaaagtaaa aagagggcgc aaaagttttg atttgtagac gttctggagc tgaaacggtg   1325820
cccatctgga taaaaagagt cagacaggag gccaatttgt ctcgatcact gctatcaaat   1325880
tgcaggtatt tctttccttg ttgacccaca ggtaacgctt taatttcctt gagaagacgc   1325940
atctgctggt ctgttaaaaa ataaacctga cctttatgga aaagtactgc tccctgataa   1326000
aagacattga ccctaggact ctcactgatt tccatttcaa aataatccga gtattctgtt   1326060
actgtaaagg caaatagatt ggcatcagca tgcatatcct gaaaaagcag ggtttggtag   1326120
ctatccactt gatggtcaaa ttgaaaatgg ggcaaggcca tcagtaaatt cacaccctgc   1326180
tcaaaaaagg tcagagggaa aaagaggtgc cgaccttggt tttggaaaaa gaggtctgga   1326240
accagccctt cctccgttag tccgtgcaag aaagtcaaaa gttcttggct ggcatcatca   1326300
aaggcttccc aagaaagaga ctcctcataa atcttgccaa tcatatacga ctttctctgc   1326360
tcgacaatcc ttaaaaaaag tggaatatcc cgaatgacat agtatttttg gctattgatt   1326420
tggccgattc tcagagtcca caagatatga ttggttcctg cttccacctg acccacagct   1326480
gataactcat aggcgcattc tgattttgga gataaaattc gatccaaaaa cttgccaccc   1326540
aaggtcacct tggtttcaac agcctctttt tcttcatgac cttcttccag actccacaag   1326600
atttcctgac cacgctcatc atttttcaga aaatgctcta gcgctgccaa atgcacacag   1326660
tagcccctct tttgaaaaaa atcacaggca caaaaaacca aatcatcctc taaactatag   1326720
cgcagttctt cttctgcaac gcgagcgtag agccgattgt tcttttcctt gatgatatca   1326780
accttaccag tttcataaag ggcaacacct tcgatacgaa ttttccccgg aatcaattta   1326840
gccatatttt cacctttacc ttatcttttt attataccat attttcgcct atgaaaatag   1326900
ccttctagga agacttttct cctagaaggc tggattttta acgtttggca aaagtagcca   1326960
caatccgctg acagacttct tgcaacagag atttgggcat agctatattg atgcgggcat   1327020
ggagacttcc ttcctctcca aaatccaaac cacggttgag gataaccttg gcttcatttc   1327080
tcaacaactc ttgcaatgtt tcatcagtca ggtcataagc tgaaaagtca agccaaatca   1327140
agtaggtacc ttgcggtttc atgaccttga ttttagtctc ttttccaaat agatccatca   1327200
cataattgat gtggtcttca aagacttgct tgagttcctc tagccaatct ttaccgtatc   1327260
gataggcagc ttctgtcgcc aaataaccca agcctgaaat ttcatgctga ttattggcca   1327320
acaggcgttt ctggaaagcc agtctcaact taggattttc aatgactgca taggaatttt   1327380
ttgttccagc aatattaaat gttttagtgg cactgctcaa gacgatagca aaatttttga   1327440
aggcaggatt gatggtattg aaagactggt gtttgtgacc aaagagggtc aaatcttggt   1327500
gaatctcatc cgaaactaac aaaacaccgt gtttttggca gagttggcca atcttctcca   1327560
acacttcttt ttcccaaaca cgtccaccag gattgtgagg gttgcaaaga acatagagtt   1327620
taacctcctc ttccaccaaa tccttttcaa gttggtcaaa gtcaatctca aacagactat   1327680
ccttttccac taaggaatta gtaatcaatc tacgattatt caacttgaca ctgcgagcaa   1327740
agggtgggta gacaggcgtg ttaattaaaa ccgcctcgcc ttcttttgta aaggtttgaa   1327800
tagctgttga gatggctggt accacaccct cgataaagac aagagcctct ttgtcaaagt   1327860
tgtaaccgta ttgtgtagct tcccactttt gaacttcctt aattaagtct tcactggcat   1327920
aggtataacc ataaaccagt tggtctgcgt aagtttgcac ggcttggcgg atttcaggca   1327980
agaccacaaa gtccatatcc gctatccaag ctggtagaac ttcactatcc gtttctgttt   1328040
ctttccattt ataggtatgg tgccctaaac ggttgggcag gcttgtaaaa tcatattttc   1328100
ccatctttgt cttatccttc tatggcttgg cgcaaatctg caatcaaatc tctagcatcc   1328160
tcaatcccaa tagacaaacg caagaggtca tctgtcaaac cataagaatg gcgtacctct   1328220
gctggaatat cagcatgagt ttgagtcgtt ggataagtaa taagactttc cactccaccc   1328280
aaactttccg caaaagagaa gaccttgaga ctgttcaaaa tatgaggaat gcgtgtttca   1328340
tcggctactt taaaggaaat catgcctcca cgaccagtgt agagaacttc cttaactgct   1328400
ggagaatcct tcaaaaaggc aaccacttct tgggcgttag ctgttgagcg ctccatacga   1328460
agagacaagg tcttgagacc acgaagcaac tggtagctgt caaatggaga caagactgcc   1328520
cctgttgtat taagattgta aaaaagcttc tcgtatagtt ctaaactatt ggtcacaacc   1328580
actccagcca agacatcatt gtggcctgct agatacttgg ttgctgaatg gagaacgata   1328640
tctgctccat cttcaatcgg acgttggtag atagggctat agaaggtatt gtccaccacc   1328700
actttggcac ccttagcatg agccaatttt gctagttttt cgatatcaaa ttccaacatc   1328760
aagggattgg ttggggtttc gatatagaga acatccacat ccttttctaa ctcggcaatc   1328820
aactcttctt ctgtattggc ataggtaaaa tggaaatgac cttcctgctc cacttggtta   1328880
aaccagcgaa aagaaccacc gtaaagatca cgcactgcca agaccttact tcctactgga   1328940
aagacgctaa aggccagtac aatagctgac atccctgagc tagtcgctag ggcatagtct   1329000
gctgactcaa tagccgccaa gacttcctca gccttactac gagttggatt tttagtgcgc   1329060
gtatagtcaa acccagtaga tcgaccaaac tctggatgct gataggtcgt tgaaaaatga   1329120
agtggtgtca ccaaagcacc tgttgcctca tcagacttga tccctgcttg tgctaaaatt   1329180
gtgttaatgt gtaattcctt gctcatacaa ttcctccaaa tctatagtaa ctattgtacc   1329240
acttattttg tatccttcgt tttcttgttt tcaagagcta gttatagttt caaactatat   1329300
aaaaagggag tttttcctgc tccctttaat agactataaa atggtgaatc tcaaaagaca   1329360
ccttcactct atcatttgct cctgcacaaa acgagcataa cgctcatgat tttccagtag   1329420
ttccttatga gttcctgagc cagtgatttt cccctcctct aagaagaaaa tacaatccac   1329480
atcttttacc gttgacaaac gatgcgctat aatcacaacc gtcttctcct ttagtacaga   1329540
atagaggcta ctgataatcg catactcaga atccgcatca agattagcag tggcttcatc   1329600
aaatataaga atttcagcat cttttaagta ggctctagct atttgaagtc tttcgttcgc   1329660
ccccctgaca agagtcgtcc gcgttcacca acttcagtat ctagtccctc tttcatggag   1329720
cgaatctcat cacctagtga tactaagtct agcactttca tcaattcatc atcagttact   1329780
aagcgattca aaccgagaca aagattgtca cgaatactgc cagataagac tgcattattt   1329840
tgtgaaaccc aagcgatttt acttctccat tcttttaagt taaaatcata tatacttgat   1329900
tgctccatta gaatatctcc tgaaagcggt ttataaaacc gctctaacaa acgcacaatc   1329960
gttgattttc ctgatccaga tggtccaaca aaagcaattt tttgcccctt gaaaattgaa   1330020
caagtaatat cctttaagac aggtcgattt tcatcataac caaaatagac atggttaaaa   1330080
ttcaaccctc gtcctgatac cgattttcct ccctcaaatt tttctttagg aactgcaagc   1330140
aagttctcca gtgcaactga agatcccttg ctcctagaat aaacagttac aaaattagct   1330200
atattactaa taggattaag taattgaaag aggtaaatca aaaacgaaac caaggttccc   1330260
acagatatat atcctgcgct gacccgataa cccccatagg ttagcatcac agctatagtc   1330320
gcaaagataa ataagagagc aaacggggtc tcaaaagaag taaccctatc tgatttcagt   1330380
gaattgtttt gtaccctttc aatacaatta tccaaaacat cctgtacact tttctctgct   1330440
tggttagtct taattaattc atgttcttga atcttttcag tcaattgccc tgttaaattt   1330500
cctcctgtaa acgacgacta tacttttcac tgatattgga aaggggcaag ataataaaca   1330560
tcatacaagg aagagtgatg aataaaagta gagaaagatt ccaatcaaga ctaaataaga   1330620
ctacaatgga accaagtacc ataactaaac tcagaataat atttgggaaa gtcgtaatta   1330680
aaaactcacg aatgacactc gtgtcattga caatggcaga agtcaactcc ccactttggc   1330740
tcttatcaaa gaaggatttc tctacataaa tcaacccctc tatcactttt ttcctgattt   1330800
ttgctatctt tttttcaccc gattgactaa acagatagta accaatagaa gaaaacaagg   1330860
cttgaccaat aaaaatcaaa aacgattgaa atactttgga gcctatattt tcaatagaac   1330920
tcccatctat taaatccttt aagataaggg gaagcaacaa agcaagtaga ctagacagaa   1330980
caagtaagaa actccccata atcaccttag tatctactct taataatttt aatttcataa   1331040
atactcctta taatatttca acggataaag tcgggaataa ctcaatttga ggataaaatc   1331100
taataaatct tcctataaca aaacgcataa catctaggat tttatatacc tgatattatg   1331160
cgtttttaag cacaaagact tcttacacaa acttatctac aattagattt tatttgacat   1331220
gttttgccaa ttcttcttgg gcttttttat tggattcttc tttttctttc aaccattttt   1331280
ctctggcttt tgcatattcg tctgttgtga caatcttatc ttgtactttg aggtatttat   1331340
atgattcaac cccttttgta ccggttaaac cataggcagc agcaaatggt acggttcttc   1331400
tcaatgatgg tgttccccca cgcgaaacac ttggaagaac taaagaacta tcaatcaacc   1331460
aagcttgaat atcagcatat ttctcataac gtttggccgg atcttgctct ttattagctt   1331520
cttccaacat ttgagtatag acatccagtc caactgcctt agccttgtca ttggcctcac   1331580
caggctctag tccaagattt tgcagaaatc ctccactatt agtattaaaa atatcgagat   1331640
aggttgacgg gtcttgataa tcaggtcccc aaccgccatg atataaatca taatctttct   1331700
gagcagctgt ttgagcaaag tagcctgaac tgtcaaactc atctgatgtt aattgctgaa   1331760
tgtcaatcac tacattatca gaacctaaaa cagattcaat tgattgtttg atagaactaa   1331820
ctccttgtat gcctacttta tctgttactt ccacagtctt atccaagtgg attgggaatt   1331880
gaacaccctt tgcttcgagt tctttcttag cttccgcaaa cttagccttg gctttctcag   1331940
gattgtagta agggtcttga ccatccgcaa agttgatacc ttgccattcc ttaccatagt   1332000
tgaccatctt agaggctaca acttcaccaa agtcttttcc cttgatactg acaaagtttg   1332060
gaggaaccac taggttacgc aaaatctttg ttgcaccttc tttcccttca gactgagccc   1332120
cataagatgt tctgtcaaaa gcaaaattga tagcctgacg gaagttttta ttgagaactg   1332180
cttcctgagt cgatttcttt tcaatgtcac ttgttttaga agtataattg taagacttcc   1332240
tatctaggtt aaaattaaag aaatatgaag ttgaattttg catactatag atgatattgt   1332300
ttttgtattt ttctttaatc ccttcatagc tggagctgtt aggaaaaaga cgagccgtag   1332360
tataagcacc agctgtaaaa ttacgttcca gtgattcttg gtcgctacca tcatagtagg   1332420
tcaatttcac atcgtctaca aagacattct tagcatccca gtaattaggg tttttcttat   1332480
attcaatagc agattttgag acaagtgctt tcatcaagaa aggtccattg tacaaaatac   1332540
tagatggatc cgccttccca aaatcatccc cttttgattt caggaaatct gcattaacag   1332600
gaaaaagtat cgttgcaagt gtttttgaat tccagtaaag ttctggttta accaaagtat   1332660
attgaaccgt ttggtcatca agtgccttga caccgacagt tgaaaagtcg cttgttttac   1332720
cagtgatata gtcatccaaa ccagcaacag agtcctgcac tagatacaag gcttctgatt   1332780
ttttatcagc tgcatattgc aaacctgtca caaaatcctg ggcagttaca ggcgcatatt   1332840
cttctccctc agaagtaaac cacttggcat ccttacgaag tttgtaggta taggtcaaac   1332900
cgtcctgaga aacagtccaa tcctctgcta atgatggaat aatattccca tattggtcat   1332960
tttctaataa cccgtctacc aaatttgcaa caatatcgga tgttgctgcg cggttttctg   1333020
ctagatagtt caagctagat ggatcacttg aataaacata gttgtaggtt tttgacgccg   1333080
tgctagaatt tccacacgcg ctcaataaaa ctcctgtacc caggacaaga cctgccaagg   1333140
ttagatattt gctcttagac tttttcattt ccggaacctc ctgctttaaa tatttgtttt   1333200
attatacaac tcttggtttg tttagtcaat tgttttttcc aaaaaatcaa aaaaacctca   1333260
ttttctattt ttgaaagata attttagcta tttttacgct aaaaaaggaa taagtttcaa   1333320
gttctcctaa aagattgttc aacttattcc ttttatttat aaatgctacc ttacgaaagc   1333380
ttaaattttg ctcgcaggcg atctgcttgg gcttttccta ttaccttatc taataaatag   1333440
gtacgcagac tcataaccat ataaagtcca ccccccatgg caccgacaag agctacataa   1333500
aagaagctcc acaaacgtcc acttggttgg aagaaaaatc ctaacagcca ctggatggtt   1333560
cctattaaca gaaacatgac tagggtcagc aaactgatta aaatggttcg cttcaaaatc   1333620
accttgcgct tgacaccagt tactttacaa atatcccgat acatcaagac gttaggaatg   1333680
atgagagcaa tggttgttga aatcaaagga ccataactgt ggaagagggc gatggtaggt   1333740
agttgcaaga ctagcttggc aatagaacca tagataaaat agagaacggc cttgcggttg   1333800
cggaacatgg cctgaagcat tggagacaag accatgtaca agcctaaaat aatagactgc   1333860
aaaactgcaa agacaaataa gcccagagcc aaactatctg gcttaccata gaagaccgta   1333920
taaagaggtt ctcctaccat aaccactcca accgttgctg gtagcaagaa cataaagagt   1333980
agggtgagac tgtcctgaac gagacgagaa gctgctttca agtccccctt gacatagttt   1334040
tccgtcaaaa gtggcaaacc aacactccca atcgaaaccc ctacagaaat caaaatcatc   1334100
gtgattttat taggattggc tgagaaataa gaaaacatga caaccaagtc ctcattgctg   1334160
tagttggtaa accagctcat actattgata aaggtcagct gatccaaaat ctggaagagc   1334220
tggatggcag accctgtcag gataaaagga atggcttcct taatggtatc aaccaagaga   1334280
cgcttactgt taatcttatc tcctgtttca aagattcttt tgagtgaacc ttcttgggca   1334340
aggaaataaa tcaagactgc aaaactggct accataccga caaaggcagc aaaggttgat   1334400
tgggtaacgg ctgctagata atctcctgaa ccgagcttca taatgataaa ggttgctagg   1334460
agcatccaga taacacgaat gacctgctca gcaatttggc tcatggcata gggtttgagg   1334520
ttattcatcc cttggaaaaa tcctcggata acactcatag acgggaaaat caagactccc   1334580
caagccaagc tttgcatgat tgggatcaag tctttgccca cgccagacaa gtctgctagc   1334640
caaggagcaa agacatacaa gactaaagca aaaaccaggc ctagtcctgt cataaagcct   1334700
aagaagctcc gaatcagggc aaagctatgc tcttcttctc gcatggtatt atacttggca   1334760
acttgcttgg ccaccgcaac tggaatcccc gctgttgaaa ccaacaagaa ccaagcatag   1334820
atattgtaac ccatggtaaa gagaccattt gccttagctg cataagcccc catccagatg   1334880
taccaaggga taatgtaaac agccccgagt aggcgactga taaagttact agccgttagc   1334940
caagcagtcc cccgtaacat ctgggcctgc tggtgattgt tttcgtgcga catagattcc   1335000
tcattcaatt ttgataacta ggaaaaactc cttatcttcc attataaact tttccttgtt   1335060
acttgtaaat ttacgacttt cggtttacaa tagaaagtat gattaagatt gaaaccgtat   1335120
tagatatttt aaagaaagat ggcctttttc gcgaaattat tgaccaaggt cattaccact   1335180
acaactacag caaagttatt tttgatagca tcagctacga cagccgaaaa gtaacagaag   1335240
acactctttt tttcgcaaaa ggcgctgcct ttaaaaaaga ataccttctt tctgctataa   1335300
cacaaggatt agcttggtat gtagctgaaa aggactacga agtcggtatc cctgtcatca   1335360
ttgtgaacga tataaagaaa gccatgagtt tgattgccat ggagttctat ggtaatccac   1335420
aggaaaaact caaactcctt gcctttactg gtactaaggg taagacaaca gcagcctatt   1335480
tcgcctataa catcttatct caagggcata gacctgctat gttgtcgacc atgaacacaa   1335540
ctcttgatgg cgagactttc tttaagtcag cgttgacaac ccctgagagt attgacctct   1335600
ttgacatgat gaatcaggct gtgcaaaatg accgtaccca cctcatcatg gaagtctcca   1335660
gtcaagccta tctggtcaaa cgtgtctatg gtctaacctt tgatgtggga gttttcctaa   1335720
atatcagccc agaccatatc ggcccgattg aacaccctag ctttgaagac tatttctacc   1335780
acaagcgtct cttgatggaa aagagccgag cagtcatcat taacagtgac atggaccact   1335840
tctcagtctt gaaagaacag gttgaagatc aagaccatga tttctatggt agccaatttg   1335900
ataaccaaat cgagaattcc aaagccttta gcttttcagc tacgggtaaa ctcgctggag   1335960
attatgatat tcaactcatt ggcaacttca accaagaaaa tgcagttgct gctggacttg   1336020
cttgtctccg tctcggagca agtcttgagg acatcaaaaa aggcatcgct gcaacccgcg   1336080
ttcctggtcg tatggaagtc ctcactcaga aaaatggagc caaggtcttc atcgactatg   1336140
cccacaatgg ggatagtctg aaaaaactca tcaatgtggt tgaaactcat caaaccggaa   1336200
agattgctct ggttctggga tcaacaggaa acaagggaga aagtcgtcgt aaggactttg   1336260
gcctcctcct caatcaacac cctgagattc aagtctttct gactgctgat gaccctaact   1336320
atgaagaccc aatggccatt gcagatgaaa ttagtagcta catcaatcat cctgttgaaa   1336380
agattgcgga tcgccaagaa gccatcaagg cggcaatggc tatcacaaat cacgaattag   1336440
atgcagttat tattgcgggt aagggagccg attgttacca aatcatccag ggcaagaaag   1336500
aatcctaccc aggagataca gccgtcgcag aaaattattt ataagaatag aaaaaatcaa   1336560
gggaaaatga aacccttgat tttttcctat tctttagtaa aaacgttttt caaaccttca   1336620
acggcacctt ctacagcacc ttttgcgtct tctacaacgt cttttgcctt agcaactgtt   1336680
ttttcaacag ctccttcaag ttctgtcttg ctgtctccag taactttacc aaaaccttct   1336740
ttgacagcgc ctgttgcttg ttccaatttg ttttcaagtg acatatgatt gtctccttta   1336800
gtttattccg atatgtgtta ccggttacat atagtttata ccgaatacta aggaaagtca   1336860
aacaatgtac tcagaaacaa gaaatcacgc taagtagaaa gttaacctct ccttatcaaa   1336920
atcgatagcc aactcatact ttccatcttc attttgcaca atatagccta agacaaccta   1336980
actgtccaca aagatatcac ggcatttctg cataagctgg tcttttttga gaaatttcaa   1337040
caaaaaagcc gtcatatact tgagggcata ctcaggatta acatctccta aaatgtcata   1337100
gagctcctgc tgtttttctg tcaaaggata ctgctgtttg accttgtaaa aataattgga   1337160
cagggtcatt ttaatgcgcg caaagtccgt cttttcaact aaaatagctg cattgatttg   1337220
attgcgcaat tccgtctcaa aactctgctc caacaaggct tgatagaccg gactagcttc   1337280
tctgacaaaa atctcttgat ccagttcaag actatcaagt gattcaagcg taggaaaatt   1337340
gaggtaatag cgcttatttt cacgtagaat caagcctgcc tttatatact cttccatgag   1337400
tttatcaact gcaacatctg gaaattgagc cttaatttcc cgtagaatca catcctcata   1337460
ctgatccaga tagcggatca attctccaaa aatggctgtc tcgtcaaacg agatggatta   1337520
aaaatctgaa tcatgaagat tcctttcttt acattgtaac agaggcgatg ctgccaactg   1337580
actaggattg gtaccagctt ggttcagagg aacaggcaga cctagttcta tgtaatactc   1337640
cctccaaaaa tcactaatct cctgctcccc atctccaaat ttcataggaa tagtttcaaa   1337700
aataggtagg atttctgcta tatactggga gcagtaaaaa ccagctgcat ctggatagaa   1337760
agaagcattg tagggtgctc caagatgttt gcaagctctt tccttcaccg actggatatc   1337820
catttctggg taaacataga ggtcgtataa atgattggac tcaaagaagt ctgccggttc   1337880
ttgacagaca acaccagcct gtccactagc atgataaatc atcccatcca aataaatggc   1337940
aacatggcta tagttacctg tggaagtctg gatggcctgt cccatgtctg acccatctct   1338000
cacaaaaatc aaatcgccat tttctaacat acttcactcc tagaaaaaag gagccgaaac   1338060
tccttgcgat ataaggcaaa ctagactttc cgattttgag ctgacaccca aaatcttacg   1338120
cattaaagct ttcagtcaat tgaggtacca cttgtttctt acgtgaaacg gcaccagcaa   1338180
ggaaggcatg attgttttca agtttgaagt tgaaagccgc ttcgaccttg tccatattgg   1338240
caccaagagc caagatttct gagtttgagt tgacgatatc tgtaatcatc aagacaaagt   1338300
cagagtagcc gtttgattcg ttggcagctt gcattgcagc ttcaatttct gcttggcgtt   1338360
ccaaaacttc agcgatgtca actgtgttca cttgggcaac acggacatta tttccgttga   1338420
gttcaaaagt cttagcatcg atatcaatca attcttcagc agatttgcta gccaagttgg   1338480
taccagcttt caacattgcc aaaccatatt cttccaagtt cacaccagcc aattcagcca   1338540
attcaggagc aatgatttta tctgttgggt gtgttgttgg tgatttcaaa agaagggtat   1338600
ctgaaatcaa acctgaaagc atcaaacctg caatctcttt aggcacagct acaccatgtt   1338660
ctttgaacat acggtaaacg attgaagacg ctgatccaac tggctccaaa cgcatgtaaa   1338720
gtgggcttgc agtttcaaag ttagccacac ggtggtggtc tacaacaccg taaacttcta   1338780
cttcagcgat atctgataca gattgttgga attcattgtg gtcagtcaag ataacttgct   1338840
ctgccccctc tgctttggca gaagtgataa cacgtggtgc ttccacacca aaatagttca   1338900
agacaaaggc tgtttcttca tttggagttc caagggcaac agcttccgta tccaaaccgt   1338960
aagcttcttt tgcaaggtag gcaaaagcta cagatgatcc gatggcatct gagtctggat   1339020
tttggtgacc aaatactaga atcttggaca tgataatacc tcattttgtt tattttcttt   1339080
attgtagcat ttttttcgct ttttgacaaa ggtaagagga gtcaaaggac tccccacgat   1339140
tcttcaaaat aactgagtaa atttctatct tgattttcag ataaaaattc ttccttctgt   1339200
ggcctcttct tacgcttgag aagagcttca gccgacatgg cttcttcctt actggcaaaa   1339260
ccttgagcat agataagttt gactggcaag cgtgctcgtg tatatttggc tcccttccca   1339320
ctattgtgga tagcgaggcg tcttctcata tcagtcgtat agcctatata gtaggatcca   1339380
tcacgacact ccagaacgta catataagcc ttatgatcca taataaatct cttcgatttc   1339440
gggcgtataa gagccatcat cattgtggac aatcaaagga ggtaagacct taaagccact   1339500
tgttgagcca tccttgatcg cctcaatcaa aagcatattg gcttcctttt ctctttttgg   1339560
ataaacaaac tgcaggcgct taggggctag attatgtcgt tttaacgtat ccaaaatatc   1339620
cagaagtcga tcaggacgat gaaccatggc caaacgccca ttagacttga gaatactctg   1339680
ggcactacga cagatttctt ccaaattagt cgtgatttcg tgtcgagcca agagataatg   1339740
ttcactctcg ttcagattag aataaggatt caccttgaaa tagggtggat tacacaaaat   1339800
catatccacc ttactcccct gaatgtgagc aggcatattt ttcaaatcat cgcagatgac   1339860
ctgcatttgc tcctctaatc cattcaaacg gacagagcgt tcagccatat ccgccaaacg   1339920
ctcctgaatc tcaacagaca atatctgtgc ttgagtacga gtgctagcaa aaagccccac   1339980
tgctccattc ccagcacaga aatccacaat caaccccttc ttaggaaaac gtggaaatcg   1340040
tgataagaga acactatcca ccgaatagct aaaaacctct ctattttgaa tgattttgat   1340100
atctgtcgaa aagagctggt taatgcgctc tcctgatttt aataattgtt cttcttccat   1340160
ggtcctatta tagcaaattc atattaacat tacaaaaaat ataaaactct aaactacttc   1340220
ttctttttta aatggtgcag ggcttctcca gtccagattg gtagcattcg tcgaaaggga   1340280
gcaaagccgt agttaaagcg gtcgcttgaa aagcgtctcc gtctaggaaa ctggtacttt   1340340
tcttcctcca aagtgcggat agaaagactg gctttccctg taaattcatc taaatccact   1340400
acctgaactt gaacctcttc atcgactttc aaggtttcat gaatattttc aataaatcct   1340460
gtccgaatct ctgaaatgtg aatcagcccc gtatcacccg tctctaactc aacaaaggca   1340520
ccgtagggct gaatccctgt aatacgcccc tttagcttat caccgatttt catcttagtc   1340580
ctcgatttca atagtttcaa ttacaacatc ttcaactggc ttgtccatag ctcctgtctc   1340640
aacagcagca atggcatcca agacagcgta agatgcttca tcagctaact gaccaaaaac   1340700
cgtgtgacgg cggtctaggt gaggtgtccc accttgattg gcatagattt ctgcaatcgg   1340760
ttctggccaa ccaccacgag taatttcttt cttagaataa ggtaggtgtt ggttttgcac   1340820
gataaagaac tggctgccgt tggtatttgg accagcattt gccatggaaa gagcaccacg   1340880
gatattgtaa agctcttctg agaattcatc ctcaaaagat tcgccgtaga ttgactcgcc   1340940
acccatacca gttccagttg ggtctccacc ttggatcata aagtccttga taatacggtg   1341000
gaaaatgaca ccatcatagt agccatcttt tgaaagagat acaaagttag ccactgtttt   1341060
aggagcatgt tcagggaaaa gcttgatacg taagtctccg tgattggtct taatagtcgc   1341120
aagaggacct tctactgttt caatgtctac ttgtggaaaa tgcaattctt tttctaccat   1341180
accaaatact tctaaggcag caaaaatgcc atcttcttct aatgtttttg taatataatc   1341240
tgctttttct ttgattttat catgagaaat tcccatggca acgctgattc cagcataatc   1341300
aaagagttcc aagtcgttga gaccatctcc aaaaaccatg accttctctg gtttcaagcc   1341360
aaggtgttcc acaacctttt ccacccccgt cgctttggag cctgaaatcg gcacaatatc   1341420
agacgaatgt tgatgccaac gaaccatgcg aagtttgtct gagagactgt caggcaagtg   1341480
caagtcatct cccttatctt caaaagtcca catctgatag atatcttctt tttcatggaa   1341540
atcgggatct acatctaagt cgggataaat tggattgata gcttcactca tcatatcggt   1341600
gcgagtcgac aacttggcat catgactccc aaccaagcca tactcaattc cttcttgctt   1341660
agcccaagag atatactcct caacatctga cttttcaatc tgatgctgat aaatgacctg   1341720
acctttttta tcttcgatat aagccccatt caaagttaca aaaaagtcag gcttgagatc   1341780
acgaatctct ggaacaacac caaaaatgcc acgtccagag gcgattcctg ttaaaattcc   1341840
tttttcacgc aactgtttaa aaacagtggg aattgtagtt ggaataaacc ctgtctttga   1341900
attccgcaat gtatcatcaa tatcaaaaaa gacaatcttg atcttctttg ccttgtatct   1341960
taatttcgcg tccatctcac tacctctttc aatctaactc tttccattat atcataaagt   1342020
aggcaaatcc cctattttca aaaagtttat catttttatt ttaatttctt ggatgagaaa   1342080
agagacatat ttatgaaaaa gctccatcgt gcttttaatg tgttctcttg ttttcaaact   1342140
cgtaaaaagg gagccactga tcctaactcg ctctctcatt tcaaagcttg tgaaaaaaga   1342200
cccgttgggg tcttaattcg ctttcttgtt ttcaagctca tgaaaaagag acccaactgg   1342260
gtcttttctt taatcttcgt ttacgaaagg catcaaagcc attacgcgag cgcgtttgat   1342320
agctgttgtt actttacgtt ggtttttagc tgaagttcct gttacacgac gaggaaggat   1342380
tttcccacgt tctgaaacga aacggctaag aagctcagta tctttgtaat caacatattc   1342440
aattttgttt gctgcgatgt aatcaacttt tttacggcgt ttgaatccgc cacgacgttg   1342500
ttgagccatg ttttttctcc tttataagtt tagttgtcca ttagaatggt aaatcatcat   1342560
ctgaaatatc caatgggttt gttgctccaa atggattttc attacgtgaa aagtctggta   1342620
ctgaatttgt aggtgctgaa tagtttgcag ttggtgcaga gtaagctcca cctgtgtgac   1342680
cctcacgcac actacggctt tccaacattt ggaaattctc agccacgacc tctgtcacgt   1342740
agacacgttg tccttgctgg ttatcgtaac tacgagtctg gatacgacct gtcaccccga   1342800
taagtgagcc ttttttagcc cagttagcaa gattttcagc ctgttggcgc cacataacga   1342860
cattgataaa atcagcctca cgttcaccat tttgactctt aaatgtacgg tttactgcaa   1342920
gagtaaaagt cgcaactgct acatttgatg gggtataacg caactcagcg tcacgtgtca   1342980
tacgccctac aagtacaaca ttgttaatca tagtttacct tcttacgcgt caattttgac   1343040
gatcatgtga cgaagaatgt cagcgttgat ttttgaaaga cggtcaaact ctttaagagc   1343100
tgcatcgtca tttgcttcaa cgttaacgat gtggtaaagt ccttcacgga aatcttggat   1343160
ttcgtatgca agacgacgtt tttcccaagt ttttgattca acaacagttg caccgttgtc   1343220
agtcaaaata gagtcaaaac gtgctaccaa agcgttttta gcttcttctt caatgtttgg   1343280
acgaatgata taaagaattt cgtatttagc cattgatatg ttcctccttt tggtctaatg   1343340
accccaagac tttgcaaggg gtaagtgagg ttcgctcaca ataaactatt atactagaaa   1343400
aaattttttt acgcaagtaa aaacactaga attcgaaaaa acgccacatg ggcgttttcc   1343460
tgttcttatg gtttgatacg gtgcaacata cgtgggaatg gaatagcttc acggatatgt   1343520
tttgttcctg ctgcgaaggt taccatacgt tcgataccga taccaaatcc tccgtgtgga   1343580
actgtaccgt atttacgaag gtcaaggtag aattcatatt ctgtacgatc catgccaagt   1343640
tcatccatct tagcgacaag ggcatcgtaa tcttcctcac gcatagaccc accgataatt   1343700
tctccatagc cttctggagc aagcaagtct gcacaaagca cgcgctctgg atttccagga   1343760
actggtttca tgtagaaggc cttgatggct gctggatagt tcatgacaaa tgttggcaca   1343820
ccaaagtggt ttgaaatcca agtttcgtgt ggtgacccaa agtcatcacc atgctcaaga   1343880
tgctcgtagt cagcatcttc atcattttca tgctcttgca agaggtcaat ggcttgatcg   1343940
taagtgatac gtttgaatgg ctctgcaatg tagcgtttca agagttctgt atcacgttcc   1344000
aaggtttcca aggcttgagg cgcgcggtca agaacacctt gtagaagagc tttcacataa   1344060
gcttcttgca agtcaagcga ctcatcatgt gtcaagtatg agtactcagc atccatcatc   1344120
cagaactcag tcaagtgacg gcgtgttttt gatttttcag cacggaaaac tggaccaaag   1344180
tcaaagacac gaccaagagc catagcccct gcttctaggt aaagctgacc tgattggctc   1344240
aagtaggctg gcgttccgaa gtagtcagtt tcaaagagtt ctgtagaatc ttctgccgca   1344300
tttcctgaaa gaattgggct gtcaaacttc ataaaaccgt tcttgtcaaa gaactcataa   1344360
gttgcataga taatagcgtt acggatttgc aacacagcta cttgcttacg agagcgtagc   1344420
cacaagtgac ggttatccat caaaaagtct gttccgtgtt cttttggtgt gattgggtag   1344480
tcttgagatt caccgatcac ttcgatgtct gtgatgtcca actcatagcc aaatttagaa   1344540
cgttcgtcct ctttgacaat acctgtcaca taaacagacg tttcttggct caagcgtttg   1344600
ataacatcaa acttctcaag tcccacttct tcaccaaatt tttcgacaaa gtttggttta   1344660
aaagccacac cttgaaagaa ggctgttcca tcacgcaatt gtaagaaagc gatttttcct   1344720
tttcctgatt tgttggcaac ccaagcgcca atcgtcactt cctgaccaac atagtctttt   1344780
acgtcaataa tcgttacacg ttttgtcatt atttttcctt ttctttttta ttctttatgg   1344840
caaaccacct ctatattgtt cccatccagg tcaatcataa aagcagcata gtaaatcgga   1344900
tgctcacttc gataaccagg agccccattg tctcgcccac ctgcctctaa gccagcctca   1344960
taacaagcct gaacttcttc cttattttct gctaaaaaag caaaatgaac aggatcttgt   1345020
gttccctgag tcagccaaaa atcaccacca ggatgagggc tgttcgggga tagaaaacta   1345080
attagagaac tagtcttaaa agccaattta tagtccaaag gagcgagaaa actcctataa   1345140
aatccttatg aaatttgtaa atcctttacc ttaatctcaa aatgatcaat cattctcact   1345200
acccataaat gctttcaagc gttcgactgc ttctttaagc gtgtctaggt ctgtcgcata   1345260
gctgaggcgg acattttctg gtgctccaaa tccagctcct gttaccaagg ccacttcggc   1345320
ttcttctaag ataacagttg taaagtctgt cacatccgtg tagcctttca tctccatggc   1345380
ctttttgaca tttgggaaga gatagaaggc cccttgcggt ttgaccactt caaatcctgg   1345440
tacctctgca aggaggggat agatggtatt aagacgttcc tcaaaggcct gacgcatgct   1345500
ttctacagta tcttgctcac ctgatagagc ctcaactgct gcatattggg ctactgctga   1345560
cggattcgaa gttgtttgac ctgcaatctt ggacatggca gcgataatgt ctgcttctcc   1345620
aacggcataa ccaatccgcc aaccagtcat ggcataagtt ttagacacac cattgatgac   1345680
cactgtttgc ttgcgaatcg cttccgatag gctagaaatc ggtgtgaact catgaccatt   1345740
ataaaccaag cggccataga tatcgtctgc taggatgaga atatcatttt ctacagccca   1345800
gtttccaatt gccaagagtt cctcacgggt gtaaatcata cctgtgggat tagatggcga   1345860
attcagcacc aaaaccttgg tcttgtcagt gcgagctgct tctaactgct ctacggtcac   1345920
cttaaagtga ttgtcttcct tagcagaaac aaagacggga acgccttctg ccatcttgac   1345980
ctgatctcca tagctaaccc agtatggggt tgggatgatg acttcatcac ctggattgac   1346040
cacagccata aagaaggtat agagagaata tttggctccc gcagcgactg tcacttgatt   1346100
tgacgctaca gaatagccgt aaaagcgctc aaagtagcta ttgaccgccg ccttaagctc   1346160
tggcagacct gaggttactg tataaaaaga agcacgccca tctcgaatcg atgcaatggc   1346220
ggcatcttgg atatttttgg gagtagtgaa atctggctca cccaaggtta gagacaaaat   1346280
atctctaccc tcagccttca gtgctttggc acgggctcca gcagccaaag tcacactttc   1346340
ttccatttct aaaacacggt tggatagttt cataggccct ccttgttgac caatgctcct   1346400
gtttcaaaat ctactagata aaaatcagat cctgacttaa cttcccagat tggcttatct   1346460
tgataacggc caaaggttat cttgtcaatc tcgccagctc ccttttcctt agaaaccgtt   1346520
tctgcttttt cttgtgaaac accctgattt agctgataaa cgtaaatctt atggtcatct   1346580
ttaccaatca ggacagcaag cgcttcttgc tgtttgttac gaccaagaac gctgtaataa   1346640
gattccaagc cattgtataa atcaacctga tcagcctgct ctaatcctgc atactgctga   1346700
gctaattttt ctccttcact tttagctgtt tgatagggtt tcatgctaag agaaaccata   1346760
tacagaaagg aaccactgat aaccacaaac aaaatcgtca tccctagacc atactgccac   1346820
agtagattat tttttgcttt gttttgtctt tttttcactc gtctatttta ccatctatta   1346880
agctttatta caagtgaata taagaatact cttcgaaaat ctcttcaaac cacgtcagct   1346940
ttatctgcaa cctcaaagct gtgctttgag caaccaattc tatttctccc ttcaaacaaa   1347000
accgattttg aaagtgaaac agttcttact ttttcagtca caaatgatta gagtttccga   1347060
aattttacaa ttttcaaata aactctgagc aaatttcttg caagttcttt tgttttgttg   1347120
taatatattt tataacaacg agagagttct cgaaatttta agaaaaagga gacacatcat   1347180
gtctaaaaaa gtattattta tcgtcggatc actacgtcaa ggttctttca accaccaaat   1347240
ggcgctcgaa gctgagaaag cacttgctgg taaagcggaa gttagctacc ttgattattc   1347300
agcccttcct ctcttcagcc aagatttgga agttccaaca catccagctg tagctgctgc   1347360
tcgtgaagca gttctcgttg cggatgctat ctggattttc tctccagtct acaacttctc   1347420
tatccctggt acagtgaaaa acttgcttga ctggctatct cgtgcccttg acttgtctga   1347480
tacacgtggc gtttctgccc ttcaagacaa gtttgtcaca gtatcatctg tagccaatgc   1347540
agggcacgat caacttttcg ctatctacaa agacctcttg ccatttatcc gtacacaagg   1347600
cgttggtgat ttcactgctg cacgtgttaa tgactctgcc tgggcagacg gaaaattggt   1347660
tcttgaagaa acagtcctaa actcacttga aaaacaagct caagacttgg tcgaagctat   1347720
caagtaacta acactcaata aaaatcaaaa agcaaactag gaagctagcc gcaagctact   1347780
caaagcactg ctttgaggtt gtagatagaa ctgacgaagt cagtaacata tatacggtaa   1347840
ggcgacactg acgtggcttg aagagatttt caaagagtat aacataataa aagcgaacaa   1347900
gactactttt ctgacactca gaagactagc ttgttcgctt ttttctcatt tataaactaa   1347960
aatagctgat gatacatatt gccaaataca aaatatctga tttctatact tcctttacaa   1348020
aaaccaatcc ctgtggttgt gacaaatctt ctcggtaaac aaatccagca aagttcaagc   1348080
gacgtgcttc ccccacagtt tgtacttgat tttctattaa agctgttaga aaggccccgc   1348140
gcgctttctt ggagatagtt gagtgaatct tcagctgacc gcctctatcc tccatgaatt   1348200
tgaaggtcac catctttgct ctgatttcct tagaaaatac agtctcaaac tctgatgaca   1348260
agagagagaa aatcacttct tccttcttca gagtttcatc ataggctgcc ttccaatggc   1348320
tcttcaaagt cttaccagcg acttttaatt tcatcaaaaa atccaaacgg tgaggagcca   1348380
tgggtgacaa gactggaaca acaccgtaca aagccgaggt aatgaaaaca tgattttcaa   1348440
gataatcttg ttccgcctcg gtcagcttat ctctcttaat gttgcggtac ataagcccat   1348500
caaaaagttt caaggctgga tagtgttgag cagtttgcct tttcaaagct tggatatttt   1348560
gaaattcttc cgccgctttc tcagctgata ccttgtagaa actctccaat tgactggcag   1348620
aatagagagc caaggcatca agcacggcct gactttctgg ttttaaagga attgcctcga   1348680
tacttgggaa gtctgtgttc atttcttttg ctgttgggat taaaattttc atattgatag   1348740
tgtagcatat tttttagcca caaccaagaa attcatttga aaaacctcgg tttgaccgag   1348800
gtttttctat ttatttgggc catcctaacc agacagccac gagaacaagg gctgtgccag   1348860
ctaaacttgt taagatagat aagaatttat cttttttctc cttgaactga gaaaaaccta   1348920
tcttcaaagc gagcagtccg agtagcattg aagcaaccat caaataaaaa cccatttctt   1348980
tgtcctccat taggcttaat ttaccttatt ataacatata ctttctgaaa aaaacctatt   1349040
tttaccgtag cttaaaggtc ttgagataat tgtcttttcc tacttgacct tcgaaggttt   1349100
taccattttc aaggtaagga aggtcatcgg atactgaagc cttgaccttg tatatcttgc   1349160
catcaacttt aaagaagtag acagtgtctc ccttgataac agctgatttg aggtctgcta   1349220
ctactccatt gatgctttct gtcgttgcat tgtcaatttc aaggtcgttt ttattggcat   1349280
acttgctgag catctcttcc actgtagtag caacgataac attttggtac tcgactgcgt   1349340
ctaccagggc gtactctttg accaagccag cattgtcctt caagcccatg atgtagagag   1349400
gcttgtcatt gaggttgatg aggattggga aggttgcttt gtaggatttc tcctgaacag   1349460
caccttctgc tgattcacgg gctgattctt ctgtcgcaga agccaagcta tacttagtga   1349520
tttctcctgt tcgcatattt tcaaggatga aaccaagatt actctcatcc gcattagccg   1349580
acgtcacacc tgtgtagaga tagatgtcat taccgataga caagtaatta tagccattgg   1349640
tagtctgggt cacgtttttc ttggaaatca tggcattcaa gaaaccgtcc ttgtacttgc   1349700
cgttgtagtt gatttgctca atggtttcct ctgctggata gatcctgtcc acccattctg   1349760
gaacatctga taagctgtat tccttggttt ctccatttgt agcatccaag ataatgactg   1349820
aagcaggacg aggaacagca agtccaaatt gcttttggta aaccgttgct acatagaaag   1349880
gattgccctc atcgtccacc tcaaaagatg gagttttaaa gattttggtc gggtacttca   1349940
agcgcaggtg acgtttgaca tcacggttaa aatactccga gtctgaatac ttgattggtg   1350000
tcttcaagtc caccaaatcc gcatttccag ttaccatgtc caccttaata tactcaccga   1350060
ttcccttggc ttgattgtta aaccatttga tagggtctgc atattctagt ggtgtgaccc   1350120
gataaggttt cccatcaatt gtcaattggg tataggtatc tgccgctacg tattgcgaca   1350180
ccttatcggt tagggaaccc aagtagcggt ctccaatttt ttcagcagta cttctatcta   1350240
ggataggaac cttactggtg tcactcttag gaaattcagt aaagtctttt tccgtaaccg   1350300
tgactacatt ggcataattt ttagcctgaa acatgctgga agttaccaag gaaaccaaag   1350360
ctgccaagag aagaattcct ccaatcgaag ctaacagaat tttccctaac cgattgattt   1350420
tgaaaccctc aagatttaag gcagcttccg ccttaccgtg gcgcacatga accgttttga   1350480
caaggtttat ccccttgcca aagccaaata atattgccac aactaacaaa tgcccacaga   1350540
ggaagaagag aaattcccag ctggtcaggt taaggggcgg taaaaagata taccaggtcg   1350600
ttgcgataaa aataagttca aagactattc gtttcatttg ctttcctcct aaatgattcg   1350660
tccttccaag tgatccagct catgctggca aatctgagct gggaagcctg tcaaggtaat   1350720
ggtctgttcc tgccacttgc tgtcacgata ggcaagcctt atggtttcat aacgcttagt   1350780
tgatctcaca cctaccaagg acaaacagcc ttcttctgcc tcataggatc cttcaaagga   1350840
cagaagcact gggttaaaca tgaccacagg aaccaagcca agattaaaga taatcacgcg   1350900
cttctgcacc ccaatcatat tggcagctag accaacacag gtatcacgat ttgctaagag   1350960
tgtatcctgc aaatctctgg caagataaag gtcctcctga cttgccggct gagacacttg   1351020
agataaaaat aagatatcct tcacaatttt cttttccact tcctcacact cctcttgctt   1351080
tttactatat tatagcaatt atagcacaaa agccgataac tgcaaaccct ttccctcaac   1351140
tgtagcaaaa agccatccga agatgacttt tttgctattt aatttctgta taagttactt   1351200
ccaagccacg cttaacagct ggacgattgg caattttttc tgcccatttt actagatttt   1351260
gataacttga ggcatccaag aattttgcag aaccttggta aagatttcct tgaactaact   1351320
gtccatacca agaccagata gcaatatctg caatcgtata gtcattgcct gcaatataag   1351380
gtttctgagc caattcctta tccaataaat ccaactggcg tttcacttcc atcgtaaaac   1351440
ggttaatagg atattccaat ttttcaggag cataattgaa gaaatgtcca aatcccccac   1351500
ctagaaaagg tgctgcacct gcttgccaga atagccaatt caaaacttct accttttcca   1351560
caggattact tggtaaaaag gctccaaatt tctcagcaag gtaaagaaga atatgagcag   1351620
actcaaagac tcttacgttt tcagtacctg actggtccaa taaggctgga atcttggaat   1351680
ttggattgag cttcacaaag tctgatccga attgatcccc atccatgata gcaatcttat   1351740
acaagtcgta agccgcttcc ttaaaaccag cttctagtaa ttcttccaat aagatagtaa   1351800
ccttcacacc atttggtgtt cccagtgaat aaagctgaaa agcttgttct ccttttggca   1351860
agttttgttc gaaacgggca cctgctgttg gtctgtttag ccccgtaaaa gctccttgat   1351920
tactagcttc atcctgccat acggtcggta attgatatgc tgacatccga aacctccctt   1351980
aaatcgcatt cttgtcaaaa ccgagtttgc gttgaataaa cttaacgatt tcgacgatga   1352040
taatcattga gaagcttcca gccataacaa ttccccattg tgacaagtct agtttggtta   1352100
cgtggaagat tccttcaagc ggttctacaa cgattgttgc catgagaagg ataaaggata   1352160
ccaagatgga ccagttaaag gtcttagact tgaatgggcc aactgtcaag atggattggt   1352220
agacagactt gacattgtag gcatggaaga gctgaatcaa accaagggtt gcaaaggcca   1352280
tcgttagggc atctgcatga atagcatgat tgtcacccac atgaactggg taagcaatcg   1352340
caaggccata aacactcata acaagagctg cttggagtac accttgataa atgatagaac   1352400
tcaaaacacc acctgagaag aagcttgcct tgcgtccacg tggtttatga ttcatgacac   1352460
caggttccgc aggttcaaca ccaagagcga tagctgggaa ggtatccgtt accaagttga   1352520
tccacaaaag atgaaccggc tgtaagacat cccaaccaaa caaggttgat aggaagatgg   1352580
ttaatacttc agcagtatta gcagaaagta ggtactgaat agtcttttga atgtttgaga   1352640
agaccttacg tccttcttcc actgcgacga taatagtcgc aaagttatca tctgcaagaa   1352700
tcatatcaga agccccctta gaaacctctg taccagtgat tcccataccg ataccgatat   1352760
cggctgtttt cagagctggc gcgtcattga caccgtcacc tgtcatggca acgactttac   1352820
cttgtttttg ccaagccttg acgatacgaa ccttgtgttc tggagacaca cgggcataaa   1352880
cagagtattg accaacgact ttttcaaatt cttcatctga cagttcattg agttcagcac   1352940
cagttaaaac gtgaccttct gtatcgtttg cgtcaatgat tcccaaacgt ttggcaatgg   1353000
cttccgctgt gtcttggtgg tcacctgtaa tcataattgg acggattccc gcttccttag   1353060
ccacacgaac agcctcagcg gcttcaggac gttcagggtc aatcatccca atcaaaccag   1353120
taaaaattaa atcattttca agctcttcag aagtgagatt ttctggaata ctatcgataa   1353180
tcttataagc acctgcaagg acacgcaagg cttgatgagc catttcagaa ttgtttgtac   1353240
gaatgagatt tgtaaccttc tcatcaatcg gagcaatatc cccagcctta tcacgaagaa   1353300
gacaacgttt taagagttgg tctggcgcac ccttgactgc tacaaggaaa cgaccatctg   1353360
gcaatgggtg aactgttgac atgagcttac ggtcagagtc aaatggcaat tcagctacac   1353420
gaggatattt ctctaagaaa cctttgacat catagccctt gtccaaggca tattggataa   1353480
aggctgtttc ggttgggtca ccaatcaagt taccttccac atcgattttc gtatcattgg   1353540
ccaagacaac tgaacgaagt agtggcattt caagacctag ttcaatatca tcagctgagt   1353600
catgtagaac cgcatcgtag aagacttttt cgactgtcat cttgttcata gtcagcgtac   1353660
cagtcttatc agaagcgatg atttcagttg aaccaagtgt ttcaactgct ggcaacttac   1353720
gaacgatgga atgtcgtttg gccaaaactt gagtaccaag agaaagaacg atggtaacga   1353780
tagcaggaag tccttctgga atggctgcaa cggcaagggc aacagaagtc aacaactcac   1353840
caagtggatt tttcccttga atgaagacac ccactacaaa agtaacaagg gcaatgacca   1353900
agatagcata ggtcaagacc ttagaaaggt tgttcaaatt ttgtttgagt ggtgtatcag   1353960
tctcatccgc atcttgaagc ataccagcaa tatgaccaac ttcagtgtac atacctgtat   1354020
tgacaacaac acccatccca cgaccatagg ttacgtttga gttttggaag gccatgttga   1354080
cacggtcacc aataccagca tctgtcgcaa gctcgactga caagtctttt tcgactggta   1354140
cagattcacc tgtcaaggct gcttcttcaa ttttaagaga gttggcttct atcaaacgta   1354200
ggtccgctgg taccacgtca cctgcttcaa gggcaacgat atcgcctggt accaattctt   1354260
tagagtcaat ctctgccatg tgtccatcac gaagaacgcg ggcaactgga ctagacatgg   1354320
atttgagggc ttcaatagct tcttcagctt ttccttcttg gtaaacacca aaggcagcgt   1354380
tgatgataac cacagctagg atgataatgg catctgcgat atcttcccca ccagaagtca   1354440
cgactgacaa gattgctgcc gcaactagga tgataatcat caaatcctta aattgctcga   1354500
tgaatttgac caagattgat cgtttctcgc cttcttcgag ttcattgtgc ccaaattcgg   1354560
caaggcgctt ttccgcctca cttgatgaca aaccttgctc ggtcgcatcc acagcctgca   1354620
agacctcttc agggctctga gtataaaacg cttggcgttt ttgttctttt gacatgtgtc   1354680
tcctccttga cattgtgtgc aaaacagact ctctttctgt catagctttt cacgacaaac   1354740
aaaaagaaac ctgttaatca taacaagtct cgctgtttaa gatagggccg gaaagcatac   1354800
ttttcagcat aaaattcgga atgacgacac tatcacaggt ttctgccagc tactcccttg   1354860
agtagtacca ttataccaaa ttttggggag ttttcaaaga gtaaaaactg ccttatttga   1354920
atttttcctt gaaaaccagt ataatggtag aatgctatgt gactagaaag gaagttgaat   1354980
gaagcaatct atctcaaatc tcaagttagc tgagcgtgga gccattatca gtatttcgac   1355040
ctatttgatc ttgtctgcag ccaaattagc agctggtcat ctccttcatt catccagttt   1355100
ggtggccgat ggttttaata acgtatcgga catcattgga aatgtggccc tcttaatcgg   1355160
gattcggatg gcgcgccagc ctgcagaccg tgaccaccgt tttggtcatt ggaagattga   1355220
agatttggca agcttgatca cttctatcat catgttctat gtcggtttcg atgttctaag   1355280
agataccatt caaaagattc tcagtcggga agaaacggtc attgatcctc ttggtgcaac   1355340
tctaggaatc atttctgcag cgattatgtt tgtggtctat ctctacaata ctcgcctcag   1355400
taagaaatcc aactccaatg cgctgaaggc agctgctaag gacaatcttt ctgacgctgt   1355460
tacctcactt ggaaccgcca ttgccatcct agctagtagt ttcaattatc cgattgtgga   1355520
taaactggtt gctatcatca tcactttctt tatcttgaag actgcctatg atatcttcat   1355580
cgagtcttcc tttagtcttt cagatggctt tgacgaccgc ctgctcgagg actaccaaaa   1355640
ggctatcatg gaaattccca aaatcagcaa ggtcaaatcg caaagaggtc gcacctacgg   1355700
tagcaacatc tacctggata ttacactaga gatgaatcct gacttgtctg tttttgaaag   1355760
ccatgaaatc gcggatcagg tcgagtctat gctggaggag cgttttggcg tctttgatac   1355820
cgatgtccat atcgaaccag cacctatccc tgaggatgaa attttagaca atgtctataa   1355880
aaaattgctt atgcgtgaac aattgattga ccaaggaaac caactagaag aactcttgac   1355940
tgatgatttt gtctatattc gccaagatgg agagcagatg gataaagagg cttataagac   1356000
caaaaaagag ttaaattctg ctatcaagga cattcaaatt acttccatca gtcaaaaaac   1356060
caaactcatc tgctatgagt tagatggtat catccatacc agtatctggc gtcgccacga   1356120
aacctggcaa aatatctttc atcaagaaac caaaaaagaa tagagaaatc ctttcatgag   1356180
acgggatttt tctattcttt tatactcaat aaaaatcaaa gtgcaaatta ggaagccggt   1356240
cacaggctgt acttgagtcg gcaatgtgaa gccgacatag tttgcacttt gattttcgaa   1356300
tagtcttaac tatcaaattc actgagatac tcatagcgtt cgtatttttc aaggagtgct   1356360
tcatttttct catccaattc tttttggaga gtagccagct taccaaagtc agagccgtta   1356420
gcctgcattt cctcttcaat agcagcgata cgtttttcca aggtttcaat atcaccttca   1356480
atacttgccc actcctgctt ttcttggtag gtcatgcgtt tcttgtcttc tcgaaccttg   1356540
accacttttt ccttttcggc cttttgcact tgattggcca tatctgtttc aaaagctttt   1356600
tcatcaagat agtcggtgta atgaccaaag aaaggacgaa tcttgccatc ctcaaaagcg   1356660
agaatcttgg tcgctacctt atccaagaaa tagcggtcgt gactgactgt taaaacggga   1356720
cctgcaaaac cttgcaagaa attctctaag actgtcaaag ttgcaatatc taggtcattg   1356780
gttggctcgt ctaaaagaag aacatttggt ttttccaaaa gcagtttgag gagataaaga   1356840
cgttttttct caccccctga caatttctca atcaaagtcc catgcgtcga acgtgggaag   1356900
aggaattgct ccagcaactc agcgatggaa gtcgtagaac caccactggt cttgacctcc   1356960
tctgccactt cctgcaggta attgatcaca cgcttgcttt catccaaacc ctcaatttgt   1357020
tgagagaaat aggcgatgcg aacagtttcc ccaatcacaa cttgtcctgc tgtcggctca   1357080
agacttcctg caatcaggtt aagtagggtt gattttccaa caccattgtc cccaacaatt   1357140
ccaatacggt ctttagcctg aactaagaga ttaaaatttt gcaaaatggg cttattttca   1357200
taggcaaagg aaacatcctg aaactcgatg actttcttcc caatccgact ggtttcaaag   1357260
ttcatagtca agtctgtctc agcactactg cctgaaactt cctttttcag atcatggaaa   1357320
cgattgatac gagcttgttg cttggtcgca cgcgcctgcg gttgtctgcg catccaggcc   1357380
aattcttgtt tgtagagttg ttcttttttg tgaagaagag ccgcgtcgcg ctcatcctgt   1357440
tccgccttta ggcgaacata gtcctggtaa tttccctggt actcggtcaa gcctgcacga   1357500
tccaactcga aaatccgtgt tgacaaagcg tctaagaaat aacgatcgtg agtgataaaa   1357560
aggacggtct tcttagaatt tttcaaaaag agggtcagcc actcaataat cgcaatatcc   1357620
agatggttgg tcggctcatc caaaagcaag aggtcgtggt tgccaagtaa gacttgtgcc   1357680
aactgtaccc gtcttctcag accacctgac aattccccaa caggagtaga taagtcttga   1357740
atgcccaatt tgctaagaac ggtcttgacc tgactttcga tttcccaagc ttggagagag   1357800
tccatctctg ccatgacacg ttccaaacgc gcctgcttgt cctcactata gtcgagcata   1357860
atcaattcat actcacgaat gagctggatt tccttgagtt cactagatag aaccgtatcc   1357920
aaaactgtct ttctatcatc aaaatcagga tcctgagtca agtaaccaat ctggtaatca   1357980
tttttagctg aaaaaggact gacatcccca tcaaatccag aaacaccaga aaggacgtcc   1358040
aaaagggtgg tcttgccagt cccattgaca ccgattaaac caattctgtc taagtcatgg   1358100
ataataaagg aaatatccct aaaaacggtc ttgtcaccaa cggatttact tagtttttca   1358160
acgataaaat cactcatttt ttctccctca ggtaagcatg gatggcttca cgattattct   1358220
ccaattctcc atcgacaatg gcaaactcaa tctctgttaa aatctctccc aagtctgggc   1358280
ctggctgata gccatattcc ttgatcaaaa taccgccatt aatctgaatc tctttcttgt   1358340
catggatagt caagctttgg tatttttctg tgatggcttg tgggttgact tcttttcctt   1358400
gagcttgacg aagattttca gcctgtaaaa gcaaatctat gtcaaagcga taacaatctc   1358460
gcttgctcaa ttctccattt tcacgcagag ccaaaataat cagcaaatcc tgaacttgct   1358520
tggcaaactg gcgtgaggtc ttccaagatt tcaaaaatga ctgcgcattt tcaatctcca   1358580
aagcccatag taaagccgcc caggcttgtt cagaggattc aaaagtaaaa tcagtctcca   1358640
aatcaaacag tctgttgagc ttgtcctggc tagatgccat atcagggaga tagtcataag   1358700
cttgactctc aatcatggaa gccaagcccc ttctccaaaa tggagccagc aagagtttat   1358760
caaactcgac gaaggtacgc tctacagaaa ttttctccaa aagcggcgtc aaggtcttca   1358820
tagctttaaa tgtttctggc tcaagtgcaa aaccaagact agcctgaaaa cggaaaccac   1358880
gcataatccg taaagcatct tcgttgaaac gctcactagc cactccaact gctcgcaaga   1358940
cttgcttttc caaatcttct aaaccatgga acaagtcaac gatttctcct gtctcatcca   1359000
aggcaaaggc gttgactgtg aaatcacggc gtttgaggtc ttcttctagc gatcgtacaa   1359060
aggaaaccgc actgggtctg cgatagtcca catagacatc ctctgtccga aaggttgtta   1359120
cctcatactc ctcatcccca tctaagacca agacggttcc atgctcgatt ccgatatcgg   1359180
ctgttcgcgg aaaaatctgc ttggtctctt ctggataaga agacgtcgca atatccacat   1359240
cgtggatagg gctatggaga agggcatctc gaacagagcc cccaacaaaa taagcctcaa   1359300
agcctgcttc tttaattttt tctaatactg gtaaagcctt ctgaaattca gaaggcattt   1359360
gcgttaatct cataataagt gttctaatcc atagacaagc tcatgacgct tgacaacttc   1359420
tttaattccc aaattgactc ctgtcatgaa ggagatgcga tcataggagt catgacggag   1359480
ggtcaaccct tctccctgat tgccaaagat gacttcctga tgagctacca agcctggcaa   1359540
acgaactgag tggatgcgca taccatcaaa gtcagcacca cgagcaccag caatcagctc   1359600
ttcctcatct gctgcacctt gctgaattga ctctcgaacc tctgccatca actcagctgt   1359660
tttaatggct gttccactcg gagcatcctt tttcttgtca tgatggagct caataatctc   1359720
cacatttggg aaatatttgg cagcctgcgt cgcaaattgc atgagtaaga cagcacccaa   1359780
ggcaaagtta ggggcaatca ggccacccaa gtcttgggca cgagaaaatt cttttagctc   1359840
tgcaatttct tcactcgtga aaccagtcgt tccaactact ggagcaaagc cattttcaag   1359900
agcaaaacgt gtattttcgt aggcaacagc tggagtagta aaatctaccc agacatccgc   1359960
ttcaaaacca gctaaatcag ccttatcctt gaaaacagga ataccctgcc attctgactc   1360020
agactcaaaa ggatccaaaa ctgccaccaa gtccaagtct ggatcagtca ataccatctg   1360080
acaagcagcc tggcccatct ttcccttaaa accggcaata attactcgaa tactcatctc   1360140
tactcctgtc taagatacaa agtccgtaag aacacaaagt gaaaatagga attccaatca   1360200
agaagtgtct acttcttgga agaactatct ttttcacaca gggttccagg cgtgttcaat   1360260
tatcaagata caaaggacct tagctgcctc tgaaaaatag ggaatggcac tgactttcca   1360320
cgaaaggcaa gacaggcatc ttttttcaag aggcaggtag tccgtgttca atttctaaga   1360380
tacaaggcat cttaactagc ctagaagcgc caactaaatc actggaatat aacccagagc   1360440
aatacttcct gctcctaggt gcgttccaat gacactacca aatgtagcaa gtgaaacatc   1360500
cgaacccaag ccaaaatcaa gcaagtgctg acgcaattct tcagcctttt caggagcatt   1360560
cccatgaatg acaatgaccc ggtattgacc tgaagccgtt gtttccttga taatttcaat   1360620
taagcgcttg gtggccttct tttcagtacg aactttttcg taaacttcaa tcacaccttg   1360680
atcgttaaaa taaaggattg gcttaatgct aagcaaattg cccaaaatgg cagccccatt   1360740
tgaaaggcgt ccacctttta ccaaatgatc caagtcatct accatgataa aggctgacgt   1360800
acggctgatt tgaatggcta gcttatcctg aatgctggca aaatcatcgc cctgatcacg   1360860
ccaattaaag acgctttcaa ccatgatgcc taggggagca cttgtaatca aagtgtctgg   1360920
gaaagcaatg gttaagccct catagtcatc gaccatatac tggatatttt ggtaaaaacc   1360980
tgaaattcca gaagatagga aaagccccaa ggcatgtgta tagccttgtt ctttgagcga   1361040
agttaagatc tcatctaact tggcaatact tggttgactg gtcttaggca attcagaagc   1361100
ctgagccatt ttttggtaaa attcctcagc agacagattg atgccttcga catattcctc   1361160
accatcaata ttgacaggaa tatccaagac aaacaagtct tctctttgca agatctctgc   1361220
actgagataa gcagaggaat ctgtgaaaac agctaatttc atattagaac tccaaattaa   1361280
ttcctggtaa gtctaatgca atttcagtca cttcgtaagt caaacgattg agcatgttca   1361340
aacatggacg agccaaggtt tccacctctt cttggttcaa ttcacttggt tcattgacaa   1361400
tacggccatc gatatggttt acttgtgaga ttgttccact aatgacaaac ttatcaaata   1361460
caatcataaa gctcaagatg acaatcaagg aagtcacttg attttcttgg tcatgttgga   1361520
gcaattggaa attcacatcc accttggttt caggagctcc attttcattt tcccattcaa   1361580
aattacgcgc atcaaaatga tactgactaa caaattcttg ttcacgttta agattcatgt   1361640
ctttctccat cggctacaat attataagct attgtaccat aattttttat tttcatctag   1361700
ttttctagga tttagtcaat cccaatttca gcacgaacta catctgtgat ggtatcaaca   1361760
tagtagttta cttcttctgt tgtaggcgct tctgccataa cacgcaagag gggttctgtt   1361820
ccacttggac gaacaaggat acggccgttc cccgccattt cttcttccat cttctcgatg   1361880
atggccttga tagctggcac ttccatggcc ttttccttca tgacgttttc cactcggata   1361940
ttaactaatt tttgtggata aatcgttact tctgccgcca actctgataa gctcttacca   1362000
gtttccttca tgattttagt caattgaact gctgataatt gaccatcacc tgtggtattg   1362060
taatccatca agataacgtg accagactgt tcaccaccaa ggttgtagcc tgattttctc   1362120
atttcttcaa caacgtagcg gtcaccaact gcagtaactg ccttgttaat accttcgcga   1362180
ttcaaggcct tgtggaaacc aaggttagac ataacagttg tcacaattgt attttgagcc   1362240
aattgtcctt tttcagaaag gtattttccg atgatgtaca taatcttgtc accatcaacg   1362300
atgtcaccat tctcatcaac agcaatcaag cggtcactgt ctccatcaaa ggccaaacca   1362360
atagctgacc cactttcttt gaccacttct tgaagggctt ctggatgtgt tgaaccaaca   1362420
ttaaggttga tgttaagacc gtctggtgtt tccccgataa ccgtcaattg ggcaccaagg   1362480
tctgcaaaga tttgacgggc actggtagaa gctgctccat tagctgtatc caaggcaacc   1362540
ttcattccat caagaggagt tccagttgaa acaaggtatc cttcatactt acgcaagcct   1362600
tctggataat ctaccaaaat tcctaagcct tctgcacttg gacgaggaag agtgtcttcc   1362660
tcagcatcta gcaaggcttc aatttctgct tctttttcat catctagttt gaagccatca   1362720
ccgccaaaga acttgattcc gttatcaagg gctgggttgt ggctagcaga aatcatgaca   1362780
ccggcacttg ctccttcagt ttcaaccaag taagctactg ctggtgttgc aaggacacca   1362840
agtttgtata cgtgaatccc tactgaaagg agacctgcca ccaaggccga ttccaacatt   1362900
tcccctgaaa tacgtgtgtc acgtcctaca aagactttcg gcgcttccgt ttcatgttga   1362960
ctaagaacat agcctccaaa acgtcctagt ttaaaggcta attctggtgt tagttctagg   1363020
ttagcttctc cacggactcc atcagtccca aaatatttac ccattgttat aaaatccttt   1363080
tctattttta attcgttttt gaactagttg ctttcgttga cgaagatgtc tccgatgaac   1363140
tgcttgtact tgaatttgat gtgcttgaac ttggtgctac tggttttgta gtcaccttca   1363200
ttattgtatc aaacggagtg ataactgccg gtaagacaac accattgcgg tcgattgcct   1363260
gcaaaggtac tgaaccactg taattacctg ttatacgttc gctagttggc aaaacagcga   1363320
taatcttatc aattctatcc aatgtctctt ggtcactcgt aatagacact tctttatctg   1363380
acaccatgac attttcaatt tgtacccgac tatcaatttg actagggtca atctctggta   1363440
caatctttac cttatccttc tgagccttct taccaatctt gactgtaatt ttttgcggag   1363500
tcgccacagc ggtcagccca ttgggtaaat cttcaatgct caaaggaact tcaatcgttc   1363560
caacaccggc atctgttagg tcagcagtaa ccttgaattt acgtgtactt tcttgcattt   1363620
cactagctag cgataggcga tttgcaccag tcaagaccac tgatacttct gaagcaaaac   1363680
cgctaataaa atacttatca ctattatagc gtatgtcaat agggacattt gttactgtat   1363740
tagtataggt ttccgttttt acctgcctag cactggtact gttttgaaaa ttcgtcgccg   1363800
tagcatagac aaataagaca caagcaaaaa agagtgagga tatgatatat aaactatttt   1363860
ttttcatgtt tccatcctcc tagcaatcgt tctttaaaac taagacccac ttcctctttt   1363920
ggaagtaaga tttcacgtaa ttctgtttca aattcatcaa gtgttaggtt gtgcttaaac   1363980
cttccattat aggttatcga aattcctccc gtttcctctg atacgacaaa agtcaaggca   1364040
tctgagactt ctgataaacc gatagccgcc cggtgtctgg tcccaaattc cttggaaatc   1364100
cctgtgtttt ttgtcaaggg cagataggca gacgtcacag cgatacgttc ttctttgata   1364160
atcaccgcac catcatgtag gggagtgttg ggaataaaaa tgttaatgag aagttctgca   1364220
gaaatcttag catccaaggg aattcctgtc gaaatatact cctgcaaggt acgtacacgc   1364280
tgaatagcaa ccaaggcccc gattttacga ggactcatgt attcaacaga cttaacaaag   1364340
gcacgaatca tctgttcctc agcactaata ggggcattgg aaaagaaatc tgtcgctctt   1364400
cccaaacgtt ccaaaccagt ccgaatctct ggagagaaga taacaaccgc cgcaataacc   1364460
ccataagtaa taatttgatt gattaaccaa gaaatcgtag tcaaaccaat catatttgca   1364520
aggatttgag ctaaaataaa caccaaaact ccacgtacca aaatcataat cttggttcct   1364580
gcaatagctt ttgtaaaatg gtataaaata taagcaacaa tcaaaatatc aatcagattg   1364640
atagctatcg tccatggact tgcaaacaaa ctggtccaat attgcagatt ggataattgt   1364700
tgaaaattca tccctgatat cctccctatc aaaacacttt cgtcctatta taccattttc   1364760
tggcattttt ttccctatcc tagtccattt tacattgaac aaaaatatga taaaataaac   1364820
tgactaaaaa aaacaaagga gaaactatgt ctcaactcta tgatattacc attgtgggtg   1364880
gtggtcctgt cgggcttttt gcagcctttt atgcccacct acgccaagcc aaggttcaaa   1364940
tcatcgactc tcttccccag ctaggtggac aacctgctat tctctaccct gaaaaggaaa   1365000
tcctagacgt accaggcttc ccaaacctga ctggagaaga gttgactaac cgcttgattg   1365060
aacagctaaa tggatttgat acccctattc atctcaatga aacggttctt gagattgaca   1365120
aacaagaaga atttgccatc acaacttcta aaggaagtca cctgactaaa acagttatca   1365180
tcgctatggg tggcggtgcc ttcaaaccac gtccgctgga acttgaaggg gttgagggct   1365240
atgaaaatat ccactaccac gtttctaaca ttcagcaata cgctggtaag aaagtgacga   1365300
ttcttggtgg gggagactcg gctgtggatt gggctttggc ttttgaaaaa atcgcaccaa   1365360
ctacccttgt tcaccgcaga gataatttcc gtgccttgga acacagtgtt caagccttgc   1365420
aagaatcatc tgtaaccatc aagacaccat tcgcccctag ccaactcctt ggaaatggaa   1365480
aaacacttga taaacttgaa atcacaaaag tcaaatctga tgaaactgaa accattgacc   1365540
tagaccacct ctttgtcaac tatggtttca aatcttctgt cggtaacctt aaaaactggg   1365600
ggctcgacct caaccgtcac aagattatcg tcaacagcaa acaggaatcc agccaagcag   1365660
gtatctatgc tatcggtgac tgctgctact atgacggaaa aattgatctg attgcgacag   1365720
gcctcggaga agctccaact gctgtcaaca acgctatcaa ctacattgac cctgaacaaa   1365780
aagtacaacc aaaacactct actagtttat aaaaaagaac cacgagtcac ataggattcg   1365840
tggttttata attcatccgc tatcttattg atttttctga gtctgtgatt gacaccactt   1365900
ttggtcagag gggtgctgag actatctgct aactgctgga tagagtagtc tgggtgctga   1365960
atcctcagtt gcgccacttc ctgcaaatct actggcaaat tttctaagcc catgatatct   1366020
ttgattttac tgatattgtt aatggtcttc atgctggcag aaactgtccg agcgatatta   1366080
gctgtctcgg cattattagc ccgattgagg tcgttacggg tttctcgcaa aatcttaacc   1366140
cgctcaaaat catcacgtgc ctgcatggct cctattacta tcaagaagtc cataatgtct   1366200
tctgctcgct ggagataggt cacagccccc ttcttgcgct caagcacctt ggcatccagt   1366260
aaaaactgtt ggagaaggga ggcaattcct tgcgcgtggt ccagataaac agaactgatt   1366320
tccaactggt acttgcctga ctcagggtca cgaatgctcc catttgccaa gaaagcgcca   1366380
cagagatagg cacgacctgc ttcctcatcc gataaaatcg cctcatcaat acctgtttcc   1366440
aggccaaaga aagagtctgc caagtgcaaa tcacttaaca aatcctgcac cttttcatct   1366500
gtaaaaacgg tatagacgcg attcttgcga agattgctcc gttggtggtg acgaatttca   1366560
gatttgattt catagagatg gagaaaggac tcatagaggt gacgggccag tttggcattt   1366620
tctgtcacaa ctgacaaagt caagcccgaa gtcgagagac cgatgctacc agacattttg   1366680
ataatggcag ataattcatg ccagctcaga tggtgttggc ccaggatttc ttcttttact   1366740
gctactgtga aactcatttt ttcacctgta taatgcgcat caactcgtcc acaatcaaat   1366800
ctccatcgtg gaaggcaccg ccattttcca gacgaaggaa gttagatgaa atcacgcgcg   1366860
aaacttgctt acaaagacct acaaaatcgt gttccacttg cactaagtat tcatcaaaac   1366920
ggttggaatt catgtattcc tgaggcactt tttcaatatt caccaagaca gtgtcgataa   1366980
aagggcgacc aaggtgacga tgcaagactt ccacgtggtc gctatctgta aagtgttccg   1367040
tctccccacg ttgggtcatg atattgcaga cataggcaat ttctgccttg gtttccaaaa   1367100
gagcccgccc aatttcctta atcacgatat tgggcaaaat agaggtaaag agggaacctg   1367160
gccctaggac aatcatgtca ctttcaagga tggtctgcac tactcgacgg ctggccagag   1367220
gcgtatcatc gtttagggca ttggtcacat agacattgtc aattatgcct cgatggtcta   1367280
caatatgact ctctccagcc acttctgtcc catcctgaaa gactgcatga agggtcaaag   1367340
gatggtcact ggaaggataa attttccctg ttgtatggaa aaatttgctc aataactgca   1367400
tggcattata ggttgaaccc tgcatttctg acaagccagc aatgatgaga tttcccaatg   1367460
gatggccagc aaaggctccg gcatcctcag agaaccgata ctgaaagacc ttctcataaa   1367520
acttaggcat atccgacatg gccacaagga cattacgaag atcacctggc ggtgtcaact   1367580
gttgcatatt ttttcggagt tcacctgaag aaccaccatc atctgccacc gtcacgatag   1367640
ctgcgatttc cacatctttt tcccgcagac tttttagaat gacgggactt ccagtccctc   1367700
caccaatcac cgttatcttt ggttttctca tgaacggttt accgtttcct ttctgcggtc   1367760
tttgtcgcga tgcccttcat taacagacca attcttggat aagtcctgcg ccaagcgttt   1367820
agcaaatgcc acactacggt gttgtccacc cgtacatccc atggcaatgg tcaaaacgga   1367880
cttaccttcc ttttggtaac ttggcagaat cggctcaatc aaggccaata aatgttgata   1367940
aaagtcttct gactcaggat ggttcatgac ataatcataa acaggttcat ccacacccgt   1368000
ttggtttctc agttctggta aataataggg atttggcaag aaacggacat caaagaccaa   1368060
gtccgcatca atcgggattc catacttaaa tccgaaagac atgacttcga tacggaaaga   1368120
ctgggcttgt tcttggtctg aaaactgctc tgcaagggtt ttgcgcagct cacgtggagt   1368180
gagttcagtc gtatccacca cattttggct catatttttc aaaggtgcca agagttcacg   1368240
ttccaacttg attccatcta aaatacgacc gtctgctgct agtgggtgac tccgtctggt   1368300
ttccttgtaa cgagcgacca attccttatc agccgcatcc aaaaagagga ttttgaaatc   1368360
caaaccatct tgattttcca actcatccaa aacagcttga atctctgaaa agaaagaacg   1368420
gctacgcata tccactacca aggccaactt aggattgtct tccttaattt caaccagctg   1368480
caaaaactta ggcaagagag ctggcggcat attatcaatg gtgaaataac ctagatcctc   1368540
gaaggactga atggctacag ttttccctgc gccactcatc cctgtcacaa tcaccaagtg   1368600
aagttgtttc tttgtcatct ttttctcctt atatcaaaag aagtttggca acaccaaact   1368660
tcaactagct tatccaatct ctgcgatgac ttcaatttcg acttttacat cacgaggaag   1368720
acgagctacc tccacagctg aacgagctgg gaattcctct ttgaaggccg tttggtaaac   1368780
ctcattaaaa ggaacaaagt cgttcatatc gctcaagaag caagttgttt tgacaacatg   1368840
gtcaaagtct gttcctgctt ctgccaaaat agcaccgatg tttttcaaga cttgctctgt   1368900
ctgttcttgg atattctctc ctacaatttc cccagtttca ggggataggg gaacttgacc   1368960
gctagcaaac aaaaggttgc caacgatttt tccttgaaca tagggtccga tagcctttgg   1369020
ggccttatct gtatgaattg tttttgccat tttcttttcc tcacaatttt tctaagattg   1369080
catcccaagc ctcatccatc cctgccttac tgacagatga aaagaggatg aaatcgtcac   1369140
tcgggtcaaa gtttaatttc tttttgattg ctgattcatg cttgttccat ttaccacgag   1369200
gaatcttgtc cgccttggtc gccacaatga tgactggaat ctcataatac ttgagaaatt   1369260
cgtacatctg cacatcatct gctgacgggt catgacgaag gtcaactaga ctgacaaccg   1369320
cacggagatt ttcccgagtc gttaagtact cctcaatcat gcacccccac ttttcacgtt   1369380
cctttttaga aacacgagca tagccataac caggcacatc cacaaagcgc atcttgtcat   1369440
caatgttaaa aaagttcagg agctgggttt taccaggttt tcctgatgta cgggcgagat   1369500
tcttacggtt caacatagtg ttgataaagc tggatttacc aacatttgaa cgccctgcta   1369560
gggcaatctc tggcagttca tcctgcggat agtgggactt attagctgca ctgagcaaga   1369620
tttcagcatt gtgtgtatta agttccatag tcacctctag gctgtttcta ggatcggttt   1369680
atccgttcca tctacagttt ctttagtgat gcgaaccaat ttcacatttt cctgactcgg   1369740
cacctcaaac atgacatcta gcatggtttc ttcgatgatg gagcgaagtc cacgcgcccc   1369800
tgtcttccgt tcgattgctt tattagcaat ctcttgaagg gcttcgtcgt caaattccaa   1369860
ctcaacatca tcataagaaa gcaaggtttg gtattgtttc accaaggcat ttcttggctc   1369920
tttcaagatg cgaaccaagt catcaacggt caattgctca agagccgcaa aaacaggcaa   1369980
gcgtccaatc aactcaggga taataccaaa tttttgaatg tcttcagcga tgatttcttg   1370040
catgtatgag ctgttttcgt caatcgcctt attattttga ccaaatccga tgactttttc   1370100
acccagacgt tgtttgacaa tttcttcaat accatcaaaa gcaccaccca cgatgaagag   1370160
gatatttttt gtatccactt gaatcatctc ttgttgtgga tgtttgcgtc caccttgagg   1370220
cggtacgcta gcaacagttc cctcaataat cttgagaagg gcttgttgca ccccttcacc   1370280
agaaacatca cgtgtgatag acacattctc actcttcttg gcaatcttgt caatttcatc   1370340
cacatagata atgccacgct ctgcacgttc gatgttaaag tcagcaacct gcaagagttt   1370400
gaggaggata ttttccacat cctcacccac ataaccagcc tccgtcagag ctgtcgcatc   1370460
cgcaatagca aaaggtacat tcaagctctt agccaaggtc tgggcaagga aagttttccc   1370520
tgaaccagtt gggccaatca tcaaaatgtt tgacttctgc aaatccacat cttctgactc   1370580
ttcgcgtgta tcgtggaaat tgatgcgttt gtagtggtta taaaccgcca ctgccaaggc   1370640
acgcttggca cgatcttgac caattacata gtggttcaag atatggagga gttcaattgg   1370700
ttttggcacc tcagacaagt ctgccaagac ttcctcaacc aattcttctc gaatgatttc   1370760
ctgagctaac tccacgcatt cattacaaat aaaagcattg ttgccagcaa ttattttttg   1370820
tacttcttct tggtttttgc cacaaaatga gcaataaacc atcatatcat tttttctatt   1370880
tgtagacatg atttccttcc attctatact gtcattctat ctaaaataag gtcatgtaaa   1370940
aagcatgaat actattgacc agattggtaa aggcatttaa ccaaaggagg atagaaagcc   1371000
cgtaacgctt tttacgaaaa gcttgtgctc ctgccagaaa gcagatgaaa cacagaaaag   1371060
ccgtgaatag accaaataaa ctccgttcca ttagacttcc tttctcttgc ggtattggat   1371120
ggtaaaatca taaggattct tctcatcttt ggcgtaaaat ttgcttgaaa ctgtctcaaa   1371180
aagagacaag tcaagttctt cagggaaata ggtatctcct tccacccgag catgaatgtg   1371240
agtgacaatc acttcatcaa ggtaaggttc aaaagcctga aaaatttgct tcccaccgat   1371300
aatgtagaga ttcttttctt gagcctgata ccagtcaaga acagactgga cgtcctgaaa   1371360
agtagcaacc ccatctatct tttcttccgg attacgcgtc aaaatcaagg tttcccgttt   1371420
tggaagcaag cgacgcccca tcccatcaaa ggtcacacgc cccatcaaga tagcatgatt   1371480
cagagttgtt tctttaaagt gctgcaattc tgctggcaaa tgccaaggca gacgattttc   1371540
cttaccaatc acaccctctt catcctgggc ccaaatagct acgattttct tagtcatgct   1371600
tccatccttt tcactgatag tactatttta tcaaaaaact caaaaaaaga ctggtttgga   1371660
atagcttaca aaatagaaaa aatctgtaag aaatttccta cagatttatc tatgtttcct   1371720
tatttcttac aaaccaggtg cttgtccaag ttcggctgca agcatccaaa ttgttttatc   1371780
tgtttcagtt ttagcgcctg caaagatacc gtttgtcaca tcgtcacctt cttcatcagt   1371840
gacatccaaa cctttttgga aaagttctga caagtaacgg tagataacaa gaacacgttc   1371900
caagctttct tcaacattac ggtattcacc agcttcttct tcgatttcac tattttgaag   1371960
gaactctgtc aatgtagaga atgggcttcc accgagtgta atcaagcgtt cactgatttc   1372020
atccaattga ccgtcaagag cttccatgta ctcatccatt tttggatgcc atacaaggaa   1372080
accacgacca tgcatatacc agtgcacttg gtgcaaagca acgtgagcta catacaaatc   1372140
agcaacagct tggttcaaga cttcctttgt ttttgccaat gctactggcg ctgcttttgt   1372200
caatgatgtt acgtctttta ctgcttcttt tttcaattct accattttct ttacctcatt   1372260
cattattttt tgtaaccact tcttaatgat tactacctta gtatactact aaggaaaacc   1372320
aatagcaaga caaagaactt atatgagaaa agttgcaata gactgataat ttaagaattc   1372380
tttagaagac aaaaagaggg ttggatgctt atagtcaatg gaaatccatc agcaaactag   1372440
gaaactaaac ccagcttgac caaagcacaa gttttgaggt cgcaggtaga actgaccaag   1372500
ctgatgtggt ttgaagaaat tccccaatac tataatagat tgaaataaga tgaaaccaag   1372560
tcgattagga aaggtaaatg aatttctaaa atgttttacc aatcacaagg tatttgtcta   1372620
tattcaatct actatataag cttcatttcc gagcaagaac ttgaatttac tcgaggatga   1372680
actatcataa aacaaagaaa aagagggtgc tactatcaca tccctctttc aaatcatcgc   1372740
ttaataccaa acgctgacat ctacgcgccc ttggattcct ttcatgtatt cagaagaggt   1372800
atattgccaa cctttttttc ctgaataatg agggttttcc cattctaaag cattcgtata   1372860
ggccgctacc cagtttacat gttttaaaat atctgggtgt tttaaacgcg tctgtaataa   1372920
actacgatag ctatagacat acacattttg ataacccgcc tgcttcatcg tgtccatgta   1372980
cttgttgatg attttaaccc aagtgcctgt atcacttgga gctctcttgc tcttatttac   1373040
atattcccaa ttctcaacat cataatagat agggtaagac aggttcatat tgtatttctt   1373100
tataagttca atggtctgtt tagcgtcact ctcagcatcg gtctcatttt cagcataggt   1373160
atagagatag acaccataag gaattcccag acggtttaac tccttaatgt tatgcgccaa   1373220
ttccttgtct tctttaccgc tataacctag acgaacaatg acaccatcca cttcgttctc   1373280
atcaataacc tttttccaat cattgatacg accattgtgc tcactaatat caatgacttt   1373340
cttagcatgt tcggttccca cttgttcttc tctattatta aagaaatagc gcttaccatc   1373400
tctgtgaacc cagccgacat tcaaatcttt tttttctttg agctcaccag aggccgcaaa   1373460
gatatagcga gtaccatcca taatcacttc gtcagtcgcc atggcaccac ttccagtcaa   1373520
atagtagttg ccttgccact cattccgagc catatagccc cacttcttga aatagtacca   1373580
tttgccgccc actttttgcc actcttggtt agcataagtt ccatcggatt ttagataaaa   1373640
ataagcagaa taggctggat catagagcca ttcattttgc atcatagctc cttgaccatt   1373700
caagaaataa cttccttgcc attggctttt agccatgtaa ccccacttct tgaagtagta   1373760
ccacttattt ccaatcaatt gccattcttg atgagcataa gccccatctg acttgagata   1373820
aaaccaactc ttgtaattac tgtcatagat ccactcgttt tgggccatat atccacctga   1373880
tttcaggtag taatttccat gccattcatt ctgcgagtaa cgaccatctg aattaatata   1373940
aaaccaagcc ttatagtagt tgtcaaaaat ccattcactt tgagctttag aaccatcatc   1374000
ctttacataa taatccccat cccagtgggc agcagcatta gtctgtactt ctgcgctcgt   1374060
ttgcgtttta ttagaagact gattttgctc tgaactactt gaagctgtcg ttgtatcctg   1374120
cgaagttttt gctacttcag tttcatttgc agcgacatga ctagttgcca agcctagtaa   1374180
acagatactt gctaatccaa tttttgtttt caatctttct ctcctataaa aaatgtaaca   1374240
gacatctgaa tgctgttcca cctagctttt gctacttact gattatttta caaagtcaag   1374300
caaagccaag aagctttcag cttcaagtga cgcaccacct acaagggcac cgtcaacgtc   1374360
tgggcaagcc atgtatgaag caacattttc aggtttaaca gaaccaccgt attgaacacg   1374420
aactttgtct gcgacttctt gaccaaagtc agcagctaca acgtcacgaa caactttaca   1374480
cattttttgt gcatcgtctt gtgaagctga tttaccagta ccgatagccc agattggctc   1374540
ataagcgata actgaggcag caacttgttc agcagtcaat ccagccaatg cagcagatac   1374600
ttgagcacct acgaattcag cagctttacc agcttcgtaa gtttcaagtg attcaccaca   1374660
acagatgatt ggaagcatac cgttcgcaaa gattgctttt gcttttttgt tgatatcttc   1374720
atcagtttca tggaagtagt cacggcgttc tgagtgaccg ataacaacgt agtcagtacc   1374780
gatttctttc aaaacttgtg ggctagtttc accagtgaaa gcacctgcat tttcaaagta   1374840
gcagttttga gcagcaactt taaggtttga gccttttgca acagcaagaa cagttgtcaa   1374900
atcaagagct ggagcagcga tacctgcttc aacaagatct gatgaaggaa gttttgatgc   1374960
aactgcttca acgaatgctt tagcttcttc tggatttttg ttcattttcc agttaccagc   1375020
gataaatggt ttacgtgaca tttcacatac ctcttttttc aatttatttt ctatttattc   1375080
tatcacaatt atacacagct tgcaaatctt actcggattt caagcctact tgcatggatt   1375140
aatccttcca gagatccatg gcatttatga aatctgcaga tacctgtgtc aactgaggat   1375200
tgcttgcttc tctttctgct ctcttggcct caatttgagc cacactcttg attccttcat   1375260
ggcgccagtt tctcaaaatc gcctgaatgt acttccagtt tggttttcca ttcaaaacag   1375320
cttcacgaag agcctcctta atcaagtcag cactggttcc atcttccttt agtgtcttgg   1375380
tcaaatcctc aatctcaaaa ggcgtcaaca atcgtcccaa ctcctgctgg aaggtttcca   1375440
ccaaatcctt gagctggttt tgaggtgtta gctggtctga acttgaatga actgctccaa   1375500
acaggtcatc caaacgttcc aaggccaaac tagcatcaaa gagcaattca atttcgccat   1375560
ttaattcgat agtacgatac tggagcagtc ccctttccgt cagattagaa atggactggt   1375620
tgacatccga aatttccttg ccaatccttt cagcaatctg gcttggcgac atttcttcta   1375680
agcctgtcgt attttgcaaa tagaaaaatt gccaaaccag aaaatcgtcg ctagaaggaa   1375740
agagttcctt aaaatgcaag agcagggcac tcggtaaaac caaggtacct gatttaaaag   1375800
cgtctaaata tgtcataatt cctcttataa atacccatat gcagatgcat catcttctat   1375860
ctttctccaa tcaaaaggcg tctcctgata gaccgcatgg tctacccaat tactgaaaaa   1375920
gagggctgca gatgaagacc aacaaagaca aggtacctga ttaacatcat catctttaaa   1375980
gtaattttct ggaatatgtg ggtcgaaacc tgcatcacga tctcgaaaat actcttttgc   1376040
caaggtatca cggtcatact ccaaatgacc aaaactataa atttctcgta aatcacgact   1376100
ggccaaaata gaaaccccaa cctgaggtcc ttctgataaa atctcgagat tggtcttgtt   1376160
taagacctct tccttagaaa tctccgtgtg ccgtgaatga ggggatacat agctatcatc   1376220
aaagcctcta aatagaaggt gaccctcttt tagggtgtcc tgaggataaa tacctgatag   1376280
cttactgtcc atctggtatt tttctacacc atagcgcaga taaagcccag cctgagcccc   1376340
ccaacagata tgaagggtcg aatagacatg agtcttagac cactcaagca tctgtctaaa   1376400
ttcctcccaa tagtccactt cctcaaatgg taaatgctca actggagcac ccgtgatgat   1376460
catcccatca aaatactcat ccttgacttc aggaaaagtt ttatagaagg tctccatgtg   1376520
ctctgaacga gttgttttag aacggtggct ctccatatag agaaaatcaa tatccagttg   1376580
taggggtgta ttagccaagt ggcgcaacaa ctgggtctct gtgaccattt tctgtggcat   1376640
gagatttaaa attaaaatct tcaaaggacg gatatcttgg tgggcagcac gttgatcatc   1376700
catgacaaag atattctctg tccgtaaaat ctcaacagct ggcaattttt tatcaattcg   1376760
aatcggcata accctctcct aactgtactc tttcaggaat aattgcatat gtttgaagac   1376820
aaatctcaaa cacttagtcc ttttattata ctgcaagaag atatagtttt caattatagt   1376880
ttttctctaa ctagttatag tctattttta tatcctagtg tagagaaaac agccctaggg   1376940
actgttttca ttaataatgc ataagaactt tgtagtcgta gtcaccaatt ttttcacggc   1377000
cgttcaattc atccaattca acaaggaagg cacaacctgc cataacacca ccaagttttt   1377060
caatcatctc gatagttgcc ttaacagttc cacctgtcgc caaaaggtca tctacaataa   1377120
gaacacgttg acctggctta atggcatccg cgtgcatagt caaggtatcg acaccgtact   1377180
ctttttcata gtcagcagaa ataacttcgc gtggcaattt acctggctta cgaacaggcg   1377240
caaaaccaat tcccaactca aaggcaactg gacaacccac gataaatcca cgagcttcag   1377300
gtcccacgat catgtcgact ttcttgtcag tagcatactg aacgatttca cgaacagcgt   1377360
agctataagc atttccatca gccatcaaag gactaatatc acggaaggta atgccttcct   1377420
ttggataatt ttcaattgtt gcaatgtaat cttttaaatt catctttttc tttctttcaa   1377480
agttttttac tctctattat agcatatttt ttaagaaaga aaaaaggaaa agttaacttc   1377540
aataattatc taacgttttg acgatttata actagccatc gcaataaagc ccaatttctg   1377600
tttattctta gcaaacattt tatacatagt taaaaactgc tttctattct cctttttaca   1377660
agcatttaca caaattttca aagttcctag caaaccttcg tcataaatca tacccgataa   1377720
tttcattaat gtcatttcac cagtcaatgc tttcacatca caataacctg attctatcat   1377780
cacctgttcc caaccatctt gagttaaagg acctacattt acatgaattg cttgtgataa   1377840
ttcctgtctg atagactctt tagcttcctt aagaagcaca tcatgtgtca agagaagacc   1377900
tccaggtttt aataccctta gatattccat tacacatttt ttcttagctt gatcggcttg   1377960
catagtcagc atagcttcat ttataacaat atcaaaacta gcatcttgat aaggaagttt   1378020
cattgcattt gctctttcaa aactgattaa atgagcaaca cctgccgttc cagcagattt   1378080
tttagccact tctaaagctt gagcatccat atcaacagca gttatcttgc aaccaaaacg   1378140
ctgtgccaac tcaattgctg tagttcccct attacacgca acctctagta ttctcttttc   1378200
ttttgaaaat cctccttctg caattaacca atctgtggca cgctttccac ctggacgtaa   1378260
gcgttttttc cccaattttg ctaaaaactt atgacctgct tctgacattt gaacacctct   1378320
gttttttctt cattataaca caaaatgata ttatctgaca attctaatct attatttgat   1378380
aaactagaat caaaagcata caagtcacca taactatagc ataaatttat tattacctct   1378440
ctagttcgaa ttcaattgct cacgtagttt acgcatatag cttcacttgt agatggtacc   1378500
cacaaataat actcaatgga aatcaaagag caaactagga aactagccgt aagctgctca   1378560
aagtacatct ttgaggttgc agataaaact gacgaaatca gtaatcatac gtacggcaag   1378620
gcgacgttga cgtggtttga agagattttc gaagagtatt aaagagcatc acaatataga   1378680
tgcataatat gacttctcta gcaaaaagga gagaagcatt ttgtttctct ccctagatta   1378740
actgatatct ctccactaca attgataaag agatatcttt tcttgtagtg ctttgaattt   1378800
tatttatttt agtagattgt tttttcagtt tctacatcga agaagtgtgc tttgttcaag   1378860
tcaaatccaa gctcaactgt tgcacctgtt tgcaagtagt cacgagcatc aacttttgca   1378920
acaaactcgt ctttaccaac ttgacagtaa aggtgagatt ctgaaccaag cagttctgat   1378980
acagagatag tcgcttttac aacacagtct gggaatgttt caaggaaagc aggttctgca   1379040
ttcacgtctt ctggacggat accaaagatc aattcttttc cttcgtagcc tttttcacga   1379100
agaactttca atgctccttc tggcactttc aaacggaaac cgtcagaaac aatttcgcta   1379160
ccaaccaatt tcacggtgat gaagttcata gctgggcttc cgatgaatcc tgcaacgaat   1379220
ttgttaactg gatttttgta aacttcttga ggagtaccga tttgttctac acgtccgata   1379280
gtacctgtac cagcagggtt cttagtagct gacataataa cgatacggtc tgcaagtgtc   1379340
atcgcttctg tttggtcgtg agttacatag atagttgtag ctccgatacg acggtgaatt   1379400
ttagcgattt cagcacgcat tgatacacga agtttggcat ccaagtttga caaaggttcg   1379460
tccatcaaga atactttcgc atcacggaca atcgcacgcc ccatggcaac acgttgacgt   1379520
tgaccacctg aaaggtcagc tggtttacgt tccaagaatt ctttcaatcc aagtatttca   1379580
gctgcttctt gaacacgttt gttaatgtct tctttgctgt atttacgcaa tttcaaaccg   1379640
aaagccatgt tgtcataaac agtcatgtgt gggtaaagag cgtagttttg gaataccatg   1379700
gcgatatcac ggtcttttgg agctacgtcg ttgacaacta cgccatcgat agatgcagta   1379760
ccttctgtaa tgtcttcaag accagcaatc atacggagtg tagttgattt accacatcct   1379820
gaaggtccta cgaaaacgat aaattcttta tctttgatgt tcaagttgaa atcttcaact   1379880
gaatagtgtt cgctgtttgg atattttttg taaatatttt taagattcaa ttctaccatg   1379940
aggtgaactc cttttgtctt ttgataatta tattatatat gaaaacgctt tatatttcta   1380000
tggcaagatg accaaaaaaa taaacaagtt ctgtgcaact tgcacaaaac tttagagaat   1380060
atcggagaat ttgaagaaga taatctttat tattcttcta tagacaaaag cagaaacaag   1380120
gatcagtttt cccatatttt cgggctctat aatatttgta gtgggtaaat cccctatgga   1380180
tattatggag cttatttttg tgtagaaaaa aagtcccata tgacctataa tgaaaagcga   1380240
caaaacaact cattagaaag aatcatatgg aacaattaca ttttatcaca aaactgctcg   1380300
atattaaaga cccaaacatc aagattctag atatcatcaa tatggatacc cacaaagaaa   1380360
ttatcgctaa gctggattat gaggctccat cttgccctga ttgtggaagt ctaatgaaga   1380420
aatatgactt tcaaaaaccg tctaagatcc cttacctcga aacaactggt atgccttcta   1380480
gaattctcct tagaaaacgc cgtttcaagt gctatcactg ttcaaaaatg atggttgctg   1380540
agactcccct ggtaaagaaa aatcaccaaa tccctcgtat catcaaccaa aaaattgctc   1380600
aaaagttaat tgaaaaaatt tctatgactg atattgccca tcagctggcc atttcaactt   1380660
caactgtcat tcgcaagctc aatgactttc actttgagca tgatttttct cggcttccaa   1380720
agattatgtc ttgggatgag tatgccttca ctaagggaaa gatgagtttc attgcgcaag   1380780
attttgataa tcttaatatt atcactgttc ttgaaggcag aacacaagct gtcatccgaa   1380840
atcactttct tcgctacgat agagccgttc gttgtcaagt gaaaatcatt acgatggata   1380900
tgtttagtcc ttactatgac ttggctaaac agctttttcc gtgtgctaaa atcgttctag   1380960
atcgtttcca tattatccaa catctcagcc gtgccatgag tcgttttcgt gttcaaatta   1381020
tgaatcagtt tgaacgaaaa tctcatgaat acaaggctat caagcgttac tggaaactca   1381080
tccaacagga tagtcgtaaa ctcagcgata aacgttttta tcgccctact tttcgcatgc   1381140
acttaacaaa taaagaaatt cttgacaaga ttttaagcta ttcagaagac ttgaaacacc   1381200
actatcagat ctatcaactc ttactttttc actttcagaa caaagaccct gagaaatttt   1381260
tcggactcat tgaggacaat ctgaagcagg ttcatcctct ttttcagact gtctttaaaa   1381320
cctttctaaa gaacaaagag aaaatcgtca acgcccttca actaccctat tcaaacgcca   1381380
aattggaagc gaccaataat ctcatcaaac ttatcaaacg caatgccttt ggttttcgaa   1381440
actttgaaaa cttcaaaaaa cggattttta tcgctctgaa catcaaaaaa gaaaggacga   1381500
aatttgtcct ttctcaagct tagcttttct tcaacccact acagttgaca aagagcctat   1381560
tttcgctgat tctccactac atttgactgg attctaattt tttagagaaa tacaaaagag   1381620
ctagctttag ctagctcttt tcctatgcgg agagagggac ttgaaccctc acgacctaaa   1381680
gcggtcacag gatccttagt cctgcgcgtc tgccaattcc gccatccccg cgtcgattac   1381740
tttactagta tatcaacttt tgggatgctt gtcaacactt tttttcaaat tttttcattt   1381800
tcaccaacca ggttactcaa aaagttcatt tagattttca tctactaact tagctccgag   1381860
tgtatttttg aaatgaccta gggcaaattg atgattttca ggccagatgg aagcaacagc   1381920
tggtttaaca atctcgatgt catatcctag attataggca tctatagctg tatgtaggac   1381980
acagatatcc gtcaagacac ctgttaagat aacggtagac actctacgct ctctcaaacg   1382040
aatatctagg tcagtccctg aaaaagctga gtaatggcgt ttatccatcc aaaagacacg   1382100
actgtctgaa ccatgctctt gataaaagat ccccaaatct ccatataaat tccgtccact   1382160
cgtcccaatc agattatgag gaggaaataa cttactttcc ggatggaaac aatcgttttc   1382220
ttcatgagca tcaatagtaa agaagatata atctcctcgt tcaaaagcta atcgagttac   1382280
cttgctgatg gcatccgaaa tcgcctgagc tggagcacct gctgttagtt tcccactatc   1382340
agcaacaaaa tcttctgtat aatcaatcga aattaaagcc tttgtcatta gtaatctctt   1382400
ttcttcactt cttcaaaaat atctgaaatc aagaccttaa gataggttcc cttcattcca   1382460
agtgagcgac tttcaataat ccccgcagac tcaagtttac gaagagcatt gacaatcaca   1382520
gagcgagtga ttccgatacg atctgcaatc actgacgcag tcaacttccc ttcatttcca   1382580
tttaattccc ctaaaattgc tgaaacagca cggagttcgg agtaagaaag ggtattgacc   1382640
gccatggtga cagcagtacg acgacgaata tttttctcat cttcttcacg ttggaagtta   1382700
agaagctgaa tcccaacaac ggtactggca atctcaacaa gaaccaagtc ctcatcttcg   1382760
aattttttat cattacgcca aataatcaaa gaaccaaggc gaatccccga tacatgaatc   1382820
ggtgcaatag tcgtcaagcc atctggaaaa tcatctctac tctcaatagg gaaaatactc   1382880
atatcatgct caacaggcaa gtttgcttct gtttcgtaaa tcatattagc cccttgaacg   1382940
tagtcatctg ggaaaatctt agtttggaag aattgctcta cgcgatctgt atttgtttta   1383000
taacgcataa aatagccaag cagacgtccc ttactattga taatgcaggc attgcaatga   1383060
ataatatccg ctaactgacg cgtaatagcg ttgtaaggga gctcatcctg caactgctcc   1383120
tctgagcgtt tcaaaattga tgtaattttt ctagtttttt ctaataaatg tgccattttt   1383180
cacctcgaat ttaatcgcta tcattataac ataaaaacgt ctctttttca ataattatct   1383240
gaaaattcct tattgacttg cattgactta caatttaatt aaaaaccaga atatttttaa   1383300
ttaaattgtt ccttttctat tgacaagttg cctatttttg tgtatcataa tattataaaa   1383360
gataatataa taattttatt tgtcttttca cattcggtct ccttatataa aaaagcgatt   1383420
cattttgaac cgctttttct tatttatcgc ctttgttacg aataacaaag cctgtttgct   1383480
tttcgcttaa agtattgcgt ggttttttat tatccttacg gtaacgtttt tccttatcaa   1383540
aacgatcgtt gccacgactt ccttttttga actcatcacg gcgaccattg ccacggcgat   1383600
cacgctctcg acggtcgtcc ccacgacggc ctccacgacc tcccttagct ttaccaccga   1383660
aaccattacc tgatggttta aacggtagtg gtttttcacg tgcaatctcc acttctggaa   1383720
ggctatctgg gtcttggact gtcagactca agatatacat tgccaattct tctggagtaa   1383780
actcagcagc caatttgcga gcatccttac caaatttctc aaagttggca cgaatggttt   1383840
catctgcaaa atcacgttcg attttcttga gagctacctg tttttttgat tggaaggatt   1383900
cttctacact tgcaggtttg agacctttca tgcgtttctt agtcaagttt tcaatgattt   1383960
gaaggtaacc catttcgttt ggagcaacaa aagtaataga ttgacctgac ttaccagcac   1384020
gacctgtacg accgatacgg tgaacataac tctcaggatc ttgtggaata tcgtagttgt   1384080
agacatgggt cacacctgaa atatccaaac cacgcgctgc aacgtctgtc gcaaccaaaa   1384140
catcaagatt gccattttta aagtcacgaa ggacacgaag acgtttgttt tggtctaggt   1384200
cgccatgaat tccttctgca cggaagccac gaattttcaa accacgagtc aattcatcca   1384260
cacggcgttt ggtacgacca aatacaatag cgagttctgg ttgtgccaca tccatgagac   1384320
gagtcatggt gtcaaatttt tcttgttcct taacacggat atagtactgg tcaaccaatt   1384380
ctgttgtcaa ttccttagcc gcaatcttga catgttcagg ggctttcata aactgaacac   1384440
cgatacgttt gatggcatct ggcatagttg ctgagaaaag caaagtttga cggttctcag   1384500
gtacacggga aataatggct tcgatgtctt caaggaagcc catgttaagc atttcatccg   1384560
cttcgtcaag gataagggtt tcaatgtctt gtaatttcaa ggccttgcgt ttaatcaagt   1384620
ccaagaggcg acctggagtt cccaccacaa tatgggcacc agatttaaga gccttaattt   1384680
gtttttcaat gcttgatccg ccatatactg aacggacttt gactccctta ctacgaccaa   1384740
agcggaagag ttcttcttga ctttggacag ctagttcacg agttggagcg atgaccaagg   1384800
cttggatagt cgcttcttct gtacggattt tttcaagggt aggcaagcca aaggctgcag   1384860
tttttcctgt accagtctga gcttgaccga taacatcctt gccttcaagg gccaaaggaa   1384920
tagtttgttc ttggatagga ctagcttcta caaaaccagc tttttcaatt tctgctagca   1384980
aatcagcaga caagtttaat tcattaaatt tcacgttatt cttctttcta aaggtggtgc   1385040
gaagccaccc tatagggctt agtttatact tttcttttta tgacgtattt tcatataact   1385100
agatataaaa tcgtgttgct tcttttccac aaaagaaaag tactgttttc tttgcaacct   1385160
atctagtata acacaagacc agagcaaaag atagccccat ttctacagaa aatcatgtaa   1385220
gcgctttttg actttctttt ttgattgaac gacctagata ataagacaaa gccaaggcga   1385280
tactgtataa aatgagaaaa acgaacaagg tttgtgtgta cgaatgagcc attttataag   1385340
tctctgctaa taaaataggt cccgctaaac cagccattgc ccaagctgtt aaaatataac   1385400
catgcagagc ggccaattcc ttggttccaa aaatatcact gagataagct ggaatcaaag   1385460
aaaaaccagc tccatagcaa gtcatcaaaa tagacatagc aactacaaat aaaacggaat   1385520
ctgtaaagag ccaaagtgag agagaaaaga aaagattgac aagcagtaat atactaaagg   1385580
ttagagggcg accgatatag tcagacaaac tcgcccagag caagcgacca aatccattga   1385640
aaatccccaa aacacccacc attactgctg catgacttgt agacaagcca gccatctcct   1385700
gtgccattgg cgatgccgct gaaattaagc ctaaaccaca agctatgttg ataaagaaaa   1385760
taatccaaag catataaaac cgattgcttt ttagagcctg atttgcagcc attccttgcg   1385820
tcaaagaggc tgttttttct ttccctgaag aagataaaat tgcaagctct tgctcatttg   1385880
gacgcttaat gaattgtgaa gctaggagca tgataataaa gtaacttgct cctaaaatat   1385940
aaaaagtttc tacaagccct acccctgcga tgaggtgttg cgctatggga ctagtcaata   1386000
aagaagcaaa accaaacccc ataatcgcta aacctgttgc gagaccacgt ttatcaggaa   1386060
accattttat aatcgtcgac acaggggtaa tatagcctgc tcccaaacca agcccaccta   1386120
aaatgccata agcgagatac aacaaccaca gctctgacgg tctattgcaa atcctgttaa   1386180
gatatttcca cctgcgtata gaaaagcaga tagacttccc atgactttcg gaccaaattt   1386240
ttctaccaaa cgccccataa atgcagccga taagcccaaa caaaagattg ctagactaaa   1386300
ggcgaaggca acagaagcct gatcccatcc cgttttttca ataatagggt tacgataaac   1386360
actccaagca taagtcgaac ccagcattaa gtgtaaaatg accccagcaa aggcaataat   1386420
ataacgattc gatttcataa aacctcctat tttcgaacat ttattctatc ttatataaaa   1386480
atagatagga ttttagttta tcaagcttgt caaaaaatta ctagtttttt gtctggaaag   1386540
cgtttttatc tttttctgtc ttttccgtag cagaattgtg caaaagtttt tttcttgtgc   1386600
tagaatgaaa ttcgaatagg aggaagataa atgttaacat acgatttaat tgttattgga   1386660
tttggtaaag ctggtaaaac actagcaggt aaattggctt cagctggcaa aaaagttgcc   1386720
ctcgttgaac gcagcaaggc tatgtacggt ggaacttgta tcaacattgg ttgtatccca   1386780
actaaaacct tgctagttgc tgctgaaaag gacttgtctt ttgaagaagt cattgctact   1386840
aaaaacacga tcactggtcg cctcaacggt aaaaactatg cgactgttgc tggtacaggc   1386900
gtagatatct ttgatgcgga agctcacttc ctttcaaata aagtcatcga aatccaagct   1386960
ggtgatgaaa agaaagaact gactgctgaa acaatcgtca tcaacactgg tgctgtttca   1387020
aacgtcttgc caatccctgg acttgctaca agcaaaaaca tctttgactc aacaggtatc   1387080
caaagcttgg acaaattacc tgaaaaactt ggaatccttg gtggcggaaa tatcggtctt   1387140
gaatttgccg gcctttacaa caaacttgga agcaaggtca cagtcctaga tgccttggat   1387200
acattcctac ctcgtgcaga accttccatc gcagctcttg ctaaacaata catggaagaa   1387260
gatggcattg aattgcttca aaatatccat actactgaaa tcaaaaacga tggtgaccaa   1387320
gtgcttgtcg taactgaaga cgaaacttac cgtttcgacg cccttctcta cgcaactgga   1387380
cgcaaaccaa atgtagaacc acttcaactt gaaaatacag atattgaact aactgaacgt   1387440
ggtgctatta aagtagacaa acactgtcaa acaaacgttc ctggtgtctt tgcagttgga   1387500
gatgtcaacg gtggccttca atttacttac atttcacttg atgacttccg tgttgtttac   1387560
agctaccttg ctggagatgg cagctataca cttgaagacc gtctcaatgt gccaaatact   1387620
atgttcatca cacctgcact ttcacaagtt ggtttgactg aaagccaagc agctgatttg   1387680
aaacttccat acgctgttaa ggaaatcccc gttgcagcaa tgcctcgtgg tcacgtaaat   1387740
ggagaccttc gcggtgcctt caaagctgtt gtcaatactg aaacaaaaga aattcttgga   1387800
gcaagcatct tctcagaagg ttctcaagaa atcatcaaca tcatcactgt tgctatggac   1387860
aacaagattc cttacactta cttcacaaaa caaatcttca ctcacccaac cttggctgag   1387920
aacttgaatg acttgtttgc gatttaagtt gagatttaat cgtatcgaac agccctcttt   1387980
gggctgtttt tacttctgcg gaatctcaaa tctgtctttc tcctctttta tgatataata   1388040
gaaacatgaa cttaaaaact actttgggcc ttcttgctgg gcgttcttcc cacttcgttt   1388100
taagccgtct tggacgtgga agtacgctcc cagggaaagt cgcccttcaa tttgataaag   1388160
atattttaca aaacctagct aagaactacg agattgtcgt tgtcactgga acaaatggaa   1388220
aaaccctgac aactgccctc actgtcggca ttttaaaaga ggtttatggt caagttctaa   1388280
ccaacccaag cggtgccaac atgattacag ggattgcaac aaccttccta acagccaaat   1388340
cttctaaaac tgggaaaaat attgccgtcc tcgaaattga cgaagccagt ctatctcgta   1388400
tctgtgacta tatccagcct agtctttttg tcattactaa tatcttccgt gaccagatgg   1388460
accgtttcgg tgaaatctat actacctata acatgatatt ggatgccatt cggaaagttc   1388520
caactgctac tgttctcctt aacggagaca gtccactttt ctacaagcca actattccaa   1388580
accctataga gtattttggt tttgacttgg aaaagggacc agcccaactg gctcactaca   1388640
ataccgaagg gattctctgt cctgactgcc aaggcatcct caaatatgag cataatacct   1388700
atgcaaactt gggtgcctat atctgtgaag gttgtggatg taaacgtcct gatctcgact   1388760
atcgtttgac aaaactggtt gagttgacca acaatcgctc tcgctttgtc atagacggcc   1388820
aagaatacgg tatccaaatc ggcgggctct ataatatcta taacgcccta gctgctgtgg   1388880
ccatcgcccg tttcctaggt gccgattcgc aactcatcaa acagggattt gacaagagcc   1388940
gtgctgtctt tggacgccaa gaaacctttc atatcggtga caaggaatgt acccttgtct   1389000
tgattaaaaa tccagtcggt gcaacccaag ctatcgaaat gatcaaacta gcaccttatc   1389060
catttagcct atctgtcctc cttaatgcca actatgcaga tggaattgac actagctgga   1389120
tctgggatgc agactttgaa caaatcactg acatggacat tcctgaaatc aacgctggcg   1389180
gtgttcgtca ttctgaaatc gctcgtcgcc tccgagtgac tggctatcca gctgagaaaa   1389240
tcactgaaac gagtaatctg gagcaagttc tcaagaccat tgagaatcaa gactgcaagc   1389300
atgcctatat tctggcaact tatactgcca tgctggaatt tcgtgaactg ctggctagtc   1389360
gtcagattgt tagaaaggag atgaactaat ggtttatact tcactttcct caaaagatgg   1389420
caattacccc tatcagctca acattgccca cctctacgga aatctcatga atacctacgg   1389480
ggacaatgga aacatcctca tgctcaagta tgtggctgaa aaactgggag cccatgtgac   1389540
cgttgacatc gtttctctcc atgatgactt tgatgaaaat cactacgaca tcgccttttt   1389600
cggtggtggt caagactttg aacaaagtat cattgcagac gacctacctg ctaaaaaaga   1389660
gagcattgac aactacatcc aaaacgacgg tgtagttctg gctatctgcg gtggtttcca   1389720
actattgggt caatattatg ttgaagcttc aggaaaacgt atcgaagggc taggggtcat   1389780
gggacactac acgctcaacc agaccaataa ccgttttatc ggtgacatca agattcacaa   1389840
tgaagatttc gatgaaacct actatggatt tgaaaatcac caaggtcgta ccttcctctc   1389900
tgatgaccaa aaaccgctgg gacaggttgt ctatggaaat ggaaacaacg aagaaaaggt   1389960
cggtgaaggg gttcattata agaatgtctt tggttcctac ttccacgggc ctatcctctc   1390020
tcgtaatgcc aatctggctt atcgcctagt tactactgcc ctcaagaaga aatatggtca   1390080
ggacatccaa ctccctgcct atgaggacat tctcagccaa gaaatcgctg aagagtacag   1390140
tgacgtcaaa agcaaggctg acttttctta aacaaaggaa aatgatatca aagaactccg   1390200
ttatcttgtc ggagtttttt gtcttttctt ttacccttct cccttgcatt ttctctcatt   1390260
ttttgccaaa atagaggggt agaaagaagg tagcatatgt ctaaattaca acaaatccta   1390320
acatatcttg aatcagaaaa actagacgtc gctgtcgtat ctgaccccgt cacaatcaat   1390380
tacctcactg gtttttacag tgatccccat gaacgccaaa tgttcctctt tgtcctagca   1390440
gatcaggaac ctctcctctt tgtcccagct cttgaagtag aacgtgcaag tagcaccgtt   1390500
tccttcccag tagtgggcta tgtcgattct gaaaatccat ggcaaaaaat caaacatgct   1390560
cttccacaac ttgacttcaa acgtgtcgct gttgagtttg acaatctcat cttgaccaaa   1390620
taccatggtt tgaaaacagt ttttgagact gctgagtttg acaacctcac tcctcgtatc   1390680
caacgcatgc gcctcatcaa atcagctgat gaagtgcaaa aaatgatggt tgcaggtctt   1390740
tatgctgaca aggctgttca tgttggtttt gacaatattt ctcttgataa gactgagaca   1390800
gatatcatcg cacaaatcga ctttgccatg aaacgtgaag gttatgaaat gagctttgat   1390860
accatggtct tgactggtga taatgctgcg aatccacacg gcattccagc agctaataag   1390920
gttgaaaatg atgctcttct cctctttgac ctgggtgttc tggtcaatgg ctatgcgtca   1390980
gatatgactc gtacagtcgc tgtcggcaaa ccagaccaat tcaagaaaga tatttacaac   1391040
ttgactcttg aagcccaaca agctgctctt gactttatca agccaggtgt gactgctcat   1391100
gaagtggacc gcgctgcccg tgaggtcatc gaaaaagctg gttatggtga gtacttcaac   1391160
caccgtctcg ggcatggtat cggtatggat gtccatgaat tcccatctat catggaagga   1391220
aacgacatgg tcatcgaaga aggcatgtgc ttctctgttg aaccaggtat ctatatccct   1391280
ggtaaagtcg gtgttcgtat tgaagactgc ggtgttgtta ccaaggatgg cttcaacctc   1391340
tttacaagca ccagcaaaga tttgctttat tttgattaaa ctatatagcc cctatgcttt   1391400
cctttcaaaa tatctagggg ctattttatt gtcatttttc tgctattatg ctaaagaaat   1391460
tggctgcaat aatctaaccc taagtgtctg gaatgataac gagggtgctc tccgctttta   1391520
tcaaagacaa gggatgaaac cccaagaaac aacaatggaa atgataattg attaagaagt   1391580
catctatcaa aagatgttag aaaaagttca atttcactag aaaatgagga aaatctcccc   1391640
acaataaaac gcatagtatc aggtattgtg tactgacccc aaacagttag acaattaatt   1391700
tatccgaagg atttagttct gtactgcaca ggactaagtc cttttagttt taccttaatt   1391760
cgtttgttgt tgtagtaatc aatatagtct ataatgactt gttccaattg gttaagtgat   1391820
ttaaatgttt tctcatagcc ataaaacatt tcggatttta aaatgccaaa gaaagattcc   1391880
atcataccgt tgtcttggct gtttcccttg cgtgacatag atgcttgaat tcccttattc   1391940
tctaggaacc gatgataaga atcgtgttgg tattgccagc cttggtcact atggagaatc   1392000
gtattctcgt agtgcttctc tttgaatgcc tgttccaaca ttgtttgtac ttattctaaa   1392060
ttaggcgaac aagaaagatt aaaagcaata atttcgctgt taaagccatc taaaactggt   1392120
gataagtaaa gcttttgagt acttgctgga atggcaaatt cagtcacatc tgtgtagcac   1392180
ttttccattg ttttagagcc ttcaaattgg gcttgaatga gattctctgc cttcttacca   1392240
acgtctcctt tatgagaaga atattttcgt ttctttcgca ttttagcttg taaattgagt   1392300
actttcatca agccttgaac tcttttatga tttaccagat aaccacgatt tcttagttct   1392360
aaatgaaccc ggcgataagc ataatttccc ttgtgttcga taaagatgga ttgaatttca   1392420
gttttaagct cttggtcttt atctgttttg tctagctgtt tcaagtgata gtagtaggtc   1392480
caacgagcta gtttaatggc ttctagaaga agatctaacg aaaactcagt cattaattct   1392540
tgaacaattt ctgtctttct tctttctctt tttcctcctt caatcggagt tctcttaact   1392600
tttttaggat ggcattctcc gctctcaggt actctccctc ttgttttctc aacaatagta   1392660
tacccgtttt tcctgtattg tgctagccag ttaagaagta tcgtacgact tgggagaccg   1392720
tattcaagag aaactctatc tttagtccag ccttcatgtc agactttatt aaccccaatt   1392780
attcacccca aatctaaaaa ccatccagaa tccttgcctt agcttagatc ctggatggtt   1392840
tcttttttca cccaatgggt gttttttact agacaaaaaa gagtttcccc tttatggtat   1392900
aagtgtagaa aaaaacacaa aaagaaagga aactcacatg aacagtttac caaatcatca   1392960
cttccaaaac aagtcttttt accaactatc tttcgatgga ggtcatttaa cccagtatgg   1393020
tggtcttatc ttttttcagg aacttttttc ccagttgaaa ctaaaagagc ggatttctaa   1393080
gtatttagta acgaatgacc aacgccgcta ctgtcgttat tcggattcag atatccttgt   1393140
ccagttcctc tttcaactgt taacaggtta tggaacggac tatgcttgta aagaattgtc   1393200
agctgatgcc tactttccaa aattgttgga aggagggcag cttgcttcac agccaacctt   1393260
atcccgtttt ctttccagaa ctgacgagga aacagtccat agtttgcgat gcctcaacct   1393320
tgaattggtc gaattctttt tacagtttca ccagctaaac caactcattg tagatatcga   1393380
ttctacccat ttcacaactt atggcaagca agaaggtgtt gcttataacg cccactatcg   1393440
tgctcatggc tatcatcctc tttatgcttt cgaggggaag acaggttatt gtttcaatgc   1393500
ccagcttcgt cctggtaatc gttattgttc tgaagaggca gacagcttta tcacacctgt   1393560
tttagaacgg tttaatcaac ttctctttcg aatggatagt ggctttgcga ccccaaaatt   1393620
atacgattta attgaaaaaa cagggcaata ctacctcata aaactcaaga aaaatactgt   1393680
tctgagccgt cttggagacc tttccctccc ttgcccacag gatgaggact taaccatctt   1393740
gccccactcc gcctactcag aaactctcta tcaagcagga tcttggtcgc acaagcgtcg   1393800
tgtctgccag ttctctgaac gaaaagaagg aaacttgttc tacgatgtta tttctctcgt   1393860
tacaaatatg acgagtggaa caagccaaga ccagtttcag ctttatcgtg gacgtggtca   1393920
agccgagaat ttcatcaagg agatgaagga gggatttttt ggcgataaaa cggatagttc   1393980
aaccttaatc aaaaacgaag ttcgtatgat gatgagctgt atcgcctaca atctctatct   1394040
ttttctcaaa catctagctg gaggtgactt ccaaacttta acaatcaaac gcttccgcca   1394100
tctttttctt cacgtggtgg gaaaatgtgt tcgaacagga cgcaagcagc tcctcaaatt   1394160
gtctagtctc tatgcctatt ccgaattgtt ttcagcactt tattctagga ttagaaaagt   1394220
caacctgaat cttcctgttc cttatgaacc acctagaaga aaagcgtcgt taatgatgca   1394280
ttaaagaaca gtcgagatga aaaaatcgtg tgacgcacca agggaggagt ctgccctttt   1394340
gaggaaatct agcgaggaaa aacgatactg gaacagcaga aagtaaaact gacctcatga   1394400
ggaggaagaa agtggctcat gaggtcaggg gttttgtaag ttacatctag ttgagagagg   1394460
tatgaatgat ttgggattaa tcatttcttg ttttaaatca ggagaatagt aacgattttt   1394520
tccttttttg acgaactcta ttccgtaacg atcaatcaat ttaatcatgt acctaatatt   1394580
agaattgttt atcccaaatt tatttgaaag cttctctaag ctatatcctt gttttctaag   1394640
ttcatagatc tgaactttat catcataagt tagtttcata ataaaaacac cccaaaagtt   1394700
agattttttc tgtctaactt ttggggggca gttcattcaa cacctgatac tatgcgtttt   1394760
tcttatttga aatacttttt actcaacctc tttatactca atgaaaatca aagtgcaaac   1394820
tagaaagcta gcctcaggct gctcaaaaca gtgttttgag gttgcagatg gaagctgacg   1394880
tggtttgaag agattttcga agagtattac ttaatcttct tgatactttg actaagaata   1394940
aatcctacaa tcatccctac catattttgc ataaaattcg gtagaatttc tgggagggct   1395000
gctgcccagc cattcatcaa agcagaaccc aaggcgtagc ctcctaccat ggcaatagtt   1395060
gctaaaataa ggcctaacca ctgacttttt cctttaaatc ctgcgaaaaa tccctgcaag   1395120
ccatggttga ccaagctaaa gaacatccac tgagggtagc ctgataagag gtcaatcaag   1395180
aaacttgcta gtcctccgac taccgctcct tcacgactac caaagtaaaa ggccgcaaag   1395240
aagacaccag catctaaaag agttagaatt cctgtaggtg ttgggatttt taagaaataa   1395300
cctagaacca cagaaagggc ggttaatagg gatacaaggg cgattttagt tgtttttgtt   1395360
tgcttcatat tgtcttactc catactgatc tgcttgtgca atagcacgat aaacgaaagc   1395420
cttagagctt tctactgctg gcaaaagttt atcaccttta accaggtgac tggcaatgct   1395480
agaggcaaag gtacaacctg caccagcatt ttggccttgg ataactggat tttctaggat   1395540
agtaaaggtc tgtccatcat aaaagacatc cacagccttg tcctgactaa gacgattgcc   1395600
tcccttgata atgactgctg gcgctcctaa atcatgcaat ttctgcgctg cagttttcat   1395660
gtcttccaag gttttaattt cctgaccgga taataattct gcttctggga gattaggcgt   1395720
aatcacactg acataaggga aaaagcgaat caactcttgg cagagctcac tgacagctac   1395780
atcatgcgtt tccttgcaga ccaagacagg atccaacacc acaggtactc ctgggcgttg   1395840
tttgataaag tccaaggcct tctcagccac gctgacagta gggagaagac caatcttaat   1395900
tcccccaaat tccacatcac gcaagctatc taattcatgt tgaaaaatgg tatcatcagt   1395960
tggaaagact tcaaatcctt tttctgtcaa ggctgtcaaa caagtcactg ctacaaaccc   1396020
atgcaagccg ttcaaggtat aggtagccaa atcagctgac agtccaccac cactaaaaat   1396080
atcatttcca gaaagtgcta aaatacgatt attcttcata acgaatctcc tttaaataca   1396140
aaccatttgg tgctgcagtg ggacctgcaa gttgcctgtc cttcttctcc aagatgagat   1396200
caatctgctc tactggcatg cggttgttac cgattttgag aagagtcccc accatattgc   1396260
gaatctgttt atacaagaaa ccatttcctg aaaaggtaaa ggtcaaaaat tgtcctgtct   1396320
catcgactat taaactagct tctgtgatgg tgcgaacctt atcctctaca ctagtcccag   1396380
aggctgtaaa accggtaaaa tcatgggttc cctctagctt tttgattgca atctgcattc   1396440
gttccacatc gagtgggtag ggaaagtggg tggcatagtg acggcgcatc ggatttttgg   1396500
gacgtcctct atccacagta aactcatagg tcttgctatg cttggcataa cggcaatgaa   1396560
aatcatctgc cacaagctca atcgaaatca catcaatatc ttcaggagac tgggtatcca   1396620
aggcaaaacg gagtttctcc tcatccatct gataaggcag gtcaaaatga atcacctgtc   1396680
ccagggcatg aaccccacta tctgtcctac cagcaccgtg aacagtaatg gcttgccctt   1396740
tatttaatct ggtcaaggtt ttttcaattt cttcctgaac gctacgcgca tgaggctggc   1396800
gctgaaagcc agcaaaggca taaccatcat aggaaatagt tgctttatat ctcgtcatag   1396860
cctctatttt atcaagaaat tagtctgtaa acaaggacct aaaacaaata ttgtatgggt   1396920
ataaaaatct catactcttc gaaaatctct tcaaaccacg tcagtttcca tctgcaacct   1396980
caacacacta ttttgagcaa cctgcggcta gctttctata gtagattgaa ataagatatg   1397040
aacaactcta ttaggaaagt caaattaatt tctagaaata ttttagcagc tacagcgtac   1397100
tattccaaac tcaatcaact atagtttgct ctttgatttt cattgagtat caaaagaaaa   1397160
acttaggaat caatcctaag ctctcttctg aagtaggtac atgacaaaga tagagattac   1397220
aatcaaccaa cctcctaaga tactaaagac caacatccca ttgtgagtta gtaagccaat   1397280
tgcacctaga acgaatgggg tcgtaaaggc tccgaaacta cagcctaata cagcaaatga   1397340
agttgcttga ttgaggagtt tagctggaat tcgttcagag acaagttgaa agaccgtcgt   1397400
caagactaca ctataggcaa atccagccag aacacttcct gctactacca cccacaagga   1397460
tgaagacaag gcaatcacga tttgccccaa gccaaaggta ataccagacc agaggagcag   1397520
tttctcttta aagatagaaa tcaagaaaga aaaactcacc ccagccacaa tcccgatcaa   1397580
ctgcatgata ctaagaacaa aactagataa ctgggcatcc cccaatcctc tttccaccat   1397640
caaacttgga atacggatgg taatagctgt attggtacaa actacaactg ccgcttcgat   1397700
agctaaggta aaaatcaagc ctttcatttc tcgagttaaa cgacttgctt ccttcgctct   1397760
tttcttgact tctttctttg attttccata agggacaaag agcagataaa ggggcagcac   1397820
caaaaatcca gcactatagg ctagaaagat agctgtccaa ccaaaggcca acaactgacc   1397880
gacggccaag gtaatgagag aagctccaac gacctctgca gaagcgcgta gccctaacat   1397940
ctgaattcgc ctttttcctt ggtagcgttc actgataata gaaatggcct tggcattgat   1398000
catcccaaga cccaaaccaa agagaagccg tgttccaaag acaaagggat aggcttggta   1398060
ccagaaggga gctgtaccgc tcaatgataa aatcagcaag cccaaactaa tctgtaagcg   1398120
ctcaggaaat attttttcta agaaaccatt tagcagtaac atcatcatga ttccaaagga   1398180
aggcaagctc accaagagct caatttgttc cttagaataa ccctgataat agtcaaacat   1398240
ggctggtagg gcactcgaaa tggaaaagga ggtaatcaaa acgagggaga gagccaaaat   1398300
gctggcccgt tctaaaaatt gtttcatgaa atctctttct atatttctct taatcttcta   1398360
cttttttgat agttatcaaa taagcaagaa aagaagaagc ctcattggtt tgtagactcc   1398420
ttcttaaatt cgaaaatgaa tcccttgtat cttatactca atgaaaatca aagagcaaac   1398480
taggaagcta gccgcaggtt gttcaaaaca gtgttttgag gttgcagatg gaaactgacg   1398540
tggtttgaag agattttcga agagtattag gatgactttc tcttgatttg cttgataaag   1398600
tagaaaataa atcctgctac catataggca acaaagataa tcagacacca cttaaacaca   1398660
acattccaac ccttgttcac attcaaaaag aagtaaggga aaggattatc cttggcattt   1398720
ggaatattga gttttagaac caagccatta aaaagagcaa acatcatata cagaaagggt   1398780
aaaatggtcc acactgctgg atcccaaatc ttgtattgac cctgtttgtc aaaaaagagg   1398840
gtatccgcta aaaaccagat gggaacgata tagtggcaaa ggaaattttc tagggtatag   1398900
aaattagtcg caatgggcgc caagaggaaa tggtaaatca cacaggtaat catgatactc   1398960
atggtgaccc caccttttaa gcgcaagaga cttggccttt gccaattttc acctacacgg   1399020
ctcataacct ttagaagata aagggtaaaa atagttacca agaggttgga cagaaccgtg   1399080
taatagagaa gcatcccaaa accaccatgc ttagtaattt caagataaac tcccgtaaaa   1399140
gccgctagaa acaagaagat acggctataa aatacaagtt tatagtgttt tgacatgctt   1399200
aaatcttcct cacaaactct gatttaagtt tcatggcacc aaaaccatca atcttacagt   1399260
cgatattgtg gtcgccttct acgatgcgga tatttttcac gcgcgtccct tgtttcaaat   1399320
cttttggcgc accttttact ttcaagtcct tgatgagagt tactgtatca ccatcagcca   1399380
atttatttcc gttggcatcg atagcgacaa gaccttcttc tacttctgca acttcagcag   1399440
gattccactc atgagcacac tctgggcaaa ccagtagggc accgtcttcg tagacatact   1399500
ctgagttaca ttttggacaa tttggtaaat tgttcatggt ttctccttat catcattcac   1399560
tattctttga aaatcaaaat ttctcgaaca gcaactatta taccctaaaa tcagcatttt   1399620
gacaaattta gaaaaaaacc gatatcaatc tatcggcttt tctacattta cattcttttt   1399680
tcagcttctg ctttgatttt ttcaactact tcttgaatgt tcaaaccagt tgtatcaagg   1399740
tagacagcat cctctgcttg tttgagagga gaagtctcac gatgactatc cttgtagtca   1399800
cgcgcagcaa tttccttttt tagggtttca aggtctgttt caattccctt ggcaatattt   1399860
tccttgtaac gacgctctgc tctctcatca acagaagcta ctaggaaaat tttcaattct   1399920
gcttgtggca atacaacagt tccaatatcg cgaccatcca tgacaatccc gccttgctgg   1399980
gcaatttctt gttggagaga aaccagtttc tcacgcactt gaggaattgc tgcaatagca   1400040
gaaacatgat tggtcacttc attttcacgg ataggatggg taatatccac atctcctaca   1400100
aaaacaagct ggtctccagt ttctgaacgt ccaaagctga ttggatgctg gtccaacaag   1400160
gctagaaggg cttcgacttc ttcaactcct aattggttct taagagccat ataggtcgct   1400220
gcacgataca tagctcctgt atcaaggtag gtgaatccaa aatccttagc aataatcttt   1400280
gcgaccgtac tcttaccgct ggaagcagga ccatcaatag caatttgaat tgttttcata   1400340
tcggctccta ttttattttt ataacatcac ctggattagc aaaccaagat cctgtagcca   1400400
tgtgcccagg attcaaggcc tctaactgag caatggagat tcctgcacga gcggcaatag   1400460
ctgcttcccc ttctcctgcg agaactttaa tcgttccttc aggattagca gcttcttctg   1400520
aactactaga agtagattct ggctctgaac tctgctcagg ctgagaacta cttgaagatg   1400580
agatttgtac tacactggca tcagaatcat gaaagccttt taaggctgct gtgcgattac   1400640
tcccccccga tgatagatag atgagaacga tgaccatcac caccacaatt acaaagaaaa   1400700
tactagctag gatcgtcaaa atacgattag ccatcctatc agcccctccg tggtttcgat   1400760
gccgacgctc tgctcttgat tcttcttgat catagatatc ttcttgccac ggttcttttg   1400820
ccatacctta ctccttgttt ttttttactt ttcttattac aatataaata tgaacatgaa   1400880
aatcacactt atacctgaac gatgtatcgc ctgtgggctt tgccaaactt attctgattt   1400940
atttgattac cacgataatg gaatcgtgcg tttttacgat gaccctgacc aactggaaaa   1401000
agaaatttct cctagtcagg atatcttaga ggctgttaaa aattgcccaa ctcgcgccct   1401060
gattggaaac caggaagcct aaatcaatgg cgataatcca ctccctctag tttagcacat   1401120
ttccatgtaa aattatagtc ttttcacttt atttttttct gtaaaatcag gaaggtcact   1401180
tttttctttg ataagataaa gtggtctttt tttagtctct aaataaatct tactgatata   1401240
cttgccgaga atcccaatgg tcaagagttg aatgcctcca agaaagagaa taacagccat   1401300
cagagaggtc caaccagatg tcggattgcc caaaatgagg gtccgaacca caacaaaaaa   1401360
ggtcatcagc agagaaagaa aacaagatag gagaccagct acaaaggcta taatcaaggg   1401420
aaaatctgaa aaattaataa tcccttcaat ggagtagaaa aagagttgcc taaaactcca   1401480
acttgtcttg ccagcctgcc tttcgacatt tggatagtcc aaatagtagg ttttgaaacc   1401540
cacccaggcg aagagcccct ttgaaaaacg attggactcg gtcaagctta aaatggcatc   1401600
gactacagac cttctcatca tacgaaaatc acggacaccc gacggcagag ctactgggct   1401660
gattttttgc atgaggcgat aaaagagaac agcacagaaa ctgcgaaaga agggttctcc   1401720
ctcccgacta gttctccgtg tcccaacgca gtccaagtct acatttttgt ctaatacatt   1401780
tttcatctca aacaacatac taggaggatc ttggaggtct gcatccatca ccaccaccaa   1401840
atctcctgtc gcatattgca agcctgcata aagggctgct tctttgccaa aatttcgaga   1401900
gaaagaaata taatggactg ccggattttg ctcccgatag gcctttaaga gttccaaggt   1401960
cccatcactt gatccatcat cgacaaagac atactcgatt tctgtttcca aatctggaag   1402020
taaagcttcc agagcctgat aaaaaagagg aagtacttcc tcttcgttta aacaagggac   1402080
gatgattgaa atcatcatct tagtcttcaa atccatttgg atgcttgctt tgccaacgcc   1402140
atgcgtcttc acacatttgg gtgatgtcga gttctgcttc ccaaccgagt tctgctttag   1402200
cttttgccgg gtctgagtag caggcagcga tatcacctgg gcgacgttct acgatgcggt   1402260
aaggaatagg acggcccacc gctttttcca tgttttggat aatttcaaga actgagtaac   1402320
ctttaccagt tccaaggtta taaacgttta gtcctgaacc tttttggatt tttttcaaag   1402380
ctgcaacgtg acccttagcc aaatcgacaa cgtggatata gtcacgaaca cctgttccat   1402440
cttccgtatc gtaatcgtct ccaaacactt gcacttgctc taattttcca acggctactt   1402500
gagtcacata tggcaagaga ttgtttggaa taccgtttgg attttctccc aaatcaccac   1402560
tctcatgggc tccgattggg ttaaagtaac gaagcaagac aacattccat tctgagtctg   1402620
ctttgtaaat atcagtcaaa atttcctcta gcatgagctt agtacgaccg tatgggttgg   1402680
tcactgaaag tgggaaatct tccaagatgg gcactgtgtg cggatccccg taaactgtcg   1402740
cagaagaact gaagatgatg tttttacagt tgttttcttc catggctttc aaaaggctga   1402800
cagttccagc gatattgttg tcatagtagg caagagggat acgtgttgat tcgccaacag   1402860
ccttcaaacc agcaaagtga atgacaccag tcggttcttc ctgcttgaaa atatctctga   1402920
gggtatctgt gtcacgaata tctgcctcat agaaaggaat ctcaactcct gtgattcctt   1402980
caacaacttc taaactctta cgattgctat tgacaagatt atccaccaca acaacttgat   1403040
gacctgcttg gatcaattca ataacagtgt gggttccaat aaaaccggca ccaccagtta   1403100
ccaaaatctt ttcttgcatc ttttttcctc gattctcaga ttattttttc ttattttacc   1403160
atttttgaca gggaatgtca tttgccatcc taaactacct gataaaattt cagtaaaatg   1403220
cttatactct tcgaaaatcc aattcaaact acgtcaacgt cgccttgcca tgggtatggt   1403280
tactgacttc gtcagttcta tccacaacct caaaacagtg ttttgagctg acttcgtcag   1403340
ttctatccac aacctcaaag cagtgctttg agtaacccgc ggctagtttc ctagtttgtt   1403400
ctttgatttt tattgagtat tattcgcttt ttactcgttt gacatagttt tcaattgggt   1403460
aatttagagg gtccaaggtc aactccttgt cttggatcag ttgggctaga tggtaaccaa   1403520
tgataggacc agttgtgagg cctgatgaac ctagtccact ggctgcatag acaccagtta   1403580
agtcaggcac ctgcccaaag aaaggagaga aatcactggt gtaggcacgg attccaacac   1403640
gctcagattt tgaagtagct tcagccaaaa tcagatagtg agtcaaggtg gcctcctcca   1403700
tttgttggag caaggtttca tctaccgtca aatcaaatcc catgtcattt tcgtgggtag   1403760
cgcctaagga taatttccca cctgcaaagg gaatcaaatc ccactcccct tctggcatga   1403820
caacagggta atcttccatg tcttgggcaa gctgataatc tcgtagttgt cctttttgag   1403880
gacggacatc cacttcataa cctaaaggct ctaacatgtc ccccaaccaa gctcccgtcg   1403940
ccaaaataac ctgctcaaac tcctcttcac caatctggta gcctgatgct aacggtgtca   1404000
gagtcacttt ttctttgacc agcttgacat gactgacttc cagcaaacga gtcactaaaa   1404060
gttggccatc tactctcgct ccaccagaag catagagcag gcggtcaaat ccctgcaaac   1404120
cagggaataa ttcattagct gaggcttggt tcagaatggc taattgccct atcaagggag   1404180
attcttctct gcgctggagg gccagttgat aaagttcttc caaattggat tcatcctttt   1404240
tcaagagaaa gactcccgaa cgctggtaaa agtcgatttc ttgtcctgat ttctctaaat   1404300
cagctaataa atccacataa aaatcagccc ccaagcgcgc catcttgtac caggctttat   1404360
tacggcgttt ggaaaaccaa ggactgataa ttcctgctgc ggccttggtg gcttgacctt   1404420
gctcatggtc aaaaacggtc acctctaggt cactttctct cgagaggtag taggcagctg   1404480
ttgctcccac aattcctgct ccaataatgg caactttttt cattgtcttc actttctaac   1404540
tagatatgat ggaaaggatt ggttgatgcc tgactaggca agatatcaat agaccacccc   1404600
ttatcttcct tccattgact aagaagtgct gcgatttttt ctacaaaaat cacttcgata   1404660
tagtgacctg ggtccaatgc aagcaaccca tcagatagca tatcctgagc agtatggtag   1404720
tagatatcac cagtgatata gacatctgcc ccctttgcca aagcatcctt atagaaagac   1404780
tgcccgcttc caccacaaat tgctactctt gaaataggct tctgcaaatc atcctcttga   1404840
taatgcacca ttcgaaggct atctaggtca aagacttgct tgacctgttg ggccaattcc   1404900
caaaatgtct gaggctgaat attcccaata cgtccaattc cacgttctgg acctgtttcc   1404960
tgcagataag tcgtctcctc gattcctagc atctgacaaa accagtcatt gagcccattt   1405020
tcaacgatat caatattggt atggctgaca taaactgcga tatcatgctt aatcaggtcg   1405080
atgtaaatct gattttgcgg acggctggca agcaagtcct tgataggacg aaagataggc   1405140
gcgtgcttga cgataatcaa gtccacaccc ttttcaatgg cctctgccac tgtctcttca   1405200
cgaatatcga gggcaaccat gaccctttgg atacccttgt ctaaagtgcc aatttgcaga   1405260
ccacggctgt ctccctccat agaaaattcc tgagggcaaa aggcttcata agcttggatc   1405320
acttcacttg ctaacatgga gcacctcctt gatagcttga atcttatcta ctagaacttg   1405380
acgttcttcc agattttttt ctgggatttg tccgagggcg aactctagct tctcagcttc   1405440
tttttgccat ttttggacaa atactggact gacttctttg gacaagaagg gaccaaagcg   1405500
aacatcactg gctgatagct tcatttgtcc tgcttccacc accaaaatct cataaaactt   1405560
tccagcttct tctaagatgc tttctgctac aatctggaat ccatgatcct gtagccagat   1405620
acgcaagtcg tcttcacgat tattgggctg gaggatcaaa cgctctacat tagctaactt   1405680
ccccaaacct tcttctaaaa tcctagcaat caaacgacca cccatgccag caatggtaat   1405740
gacagacact tggtcagtct cttcaaaagc tgccaagcca ttggctaaac ggacttggat   1405800
tttctccttt aggccgtgag cctcaacatt tttaaccgca gactgatagg gaccttccac   1405860
cacctcacct gcaatagcgc ttttgatttg gcctctctca accaactcga taggcagata   1405920
agcatggtca cttcccacat ctagtaaaat agccccctgt gacacaaagg aagctaccaa   1405980
ttctaatctc tttgaaatca tcttctctca ctttccaaaa ctctattacc tcttattata   1406040
ccacatttca atcttcaact tcccagtaat ataagcacct ctggcgaaag aagtttcaat   1406100
gtcctaaagt aataagtgaa tccaattgaa agattttaaa caatttgcaa aaatgtcaaa   1406160
aaataaaaaa taaacagttt attcagaaaa ttcttgacat ataaaaacac atggtagaat   1406220
ataattagaa agttagaaaa aataaaagtt tgactaaaat ttgtatttga aggtggtgtt   1406280
cagataagaa atttagtcag acgaaccacg aatttgctct atgctttctg gaatttatca   1406340
taacaggagg atacagtcat ggaacaaaca ttgtttgaat tagaactact tccagaggaa   1406400
gatatcattg tcacaggtct ccctaagtat tgttctttta cttgtttaat tacaggtcgc   1406460
tagttatatt ttatataaaa taagtagctt tacttacgga ataggctagt gctgtgtctc   1406520
tagcctattt taataattag gagtttgtta tggatttatt agagaaagaa tgtttaaaat   1406580
gtgataaaaa tttccaacag ggtgatattt ggaattacta ttatttatca gataagatgc   1406640
ctgcacaagg gtggaaaata cacataagct cccaaataaa agacgctgta aatattttta   1406700
agattgtgta taaactatcc caactaaata attgtagctt taaagttgtt aaaaatttag   1406760
aggaattaaa aaaaattaat tcccctaggg aaatgagccc tactgctaac aaatttataa   1406820
ctctatatcc taagtcagaa tctgaagcta agagtatgat ttgtaatctt acgaatagac   1406880
tgtcagaatt taaggctcca aaaatactat ctgactatca atgtggaatg cattctccag   1406940
ttcattatag atatggggct tttttaaaaa aacaagctta tgatgaaaaa aataaaaaag   1407000
tcatctattt attgctagat gaaaaaagga agaactatgt agaagataag agacaaaatt   1407060
tccctagtct tcctagctgg aaaatggatt tattttcaga agaagaaaaa aggatttatt   1407120
ttcaaaccac atgtgaagtt tcaagtaagg actctgcaat aaataaatac aaaatggaaa   1407180
aaattattaa gagatcaaat aaaggaaatg tttatcgggc aattagaaaa tcggacgggc   1407240
aaaaagtaat catcaagcag tcaagacctt ttgtgaatta tgatgctgaa ggagaatgga   1407300
cagctcttga tgatataaaa aatgaagctc acatgctaaa aaaattagcc gataaaagtt   1407360
atactactaa tttaactgat gaattttata tcgtggatga ttattttctt gttcaggaac   1407420
aagttgacgg gttaaacttt gaagaattta ttcgagaaac agaacactcc ttaaatatta   1407480
gagaaaaaac actggataac attgtgaata tagtaagtta catccataaa ctgggaatat   1407540
aaaattgtag atatagctcc tacaaatttt atatatacca aaaatgtact gcaccccaaa   1407600
agttagacaa ttaatttatc cgaaggattt agttctgtat tgcacagggc taagtccttt   1407660
tagctttacc ttaattctct tgttgttgta ataatcaatg tagtccacaa tagcttgttc   1407720
aaggttttct aaagatctaa agttcttctc ataaccataa aacatctccg atttcaaaat   1407780
gccaaagaaa gattccatca tgccgttgtc tgggctgttg cccttgcgtg acatggatgc   1407840
ttgaattccc ttactctcta ggaaccgatg ataagaatcg tgttggtatt gccagccttg   1407900
gtcactatgg agaatcgtat tctcatagtg cttctctttg aatgcctgtt ccaacattgt   1407960
ttgtacttat tctaaattag gcgaacaaga aagattaaaa gcaataattt cgctgttaaa   1408020
gccatctaaa actggtgata agtaaagttt ttgagtactt gctggaatgg caaattctgt   1408080
cacatctgtg tagcactttt ccattgtttt agagccttca aattggcctt gaatgagatt   1408140
ctctgctttc ttaccaacgt ctcctttatg agaagaatat tttcgtttct gtcgcatttt   1408200
agcttgtaaa ttgagtactt tcatcaagcc ttgaactctt ttatgattta ccagataagc   1408260
acgatttctt agttctaaat gaacccggcg ataagcataa tttcccttgt gttcgataaa   1408320
gatggattga atttcagctt taagctcttg gtccttatct ggtttatcta gctgtttcaa   1408380
gtgatagtag taggtccaac gagctagttt aatggctttt agaagaagat ctaacgaaaa   1408440
ctcagtcatt aattcttgaa caatttctgt ctttcttatt tctctttttc ctccttcaat   1408500
cggagttctc ttaacttttt taggatggca ttctccgctc tcaggtactc tcccttttgt   1408560
tttctcaaca atagtatacc cgtttttcct gtattgtgct agccagttaa gaagtatcgt   1408620
acgacttggg agaccgtatt caagagaaac tctatcttta gtccagcctt catgtcagac   1408680
tttatgaatc atttcttgtt ttaaatcagg agaatagtaa cgatttttcc cttttttgac   1408740
gaactctatt ccgtaacgat caatcaattt aatcatgtac ctaagattag aattatttat   1408800
cccaaattta tttgaaagct tctctaagat atatccttgt tttctaagtt catagaactg   1408860
aactttatca tcataagtta atttcataat aaaaacaccc caaaagttag atttttttct   1408920
gtctaacttt tggggtgcag ttcatcattt caacatccta tactatgcgt tttttaattt   1408980
tagagacctt ctctctagct ttcaaaaaac ttacaatatc ctaagtcaat ctgtggatgc   1409040
tgtgtttatt gattaaagaa actatctaga tcagtagcaa agtgattagc gtacttcgca   1409100
accgtttcag ggtatactct attgtgtata ctatctacta taactttcgt agataaatta   1409160
ttacattttc attacagttt ttaaataacc aatcatctga ttagtgtcta tcactacatc   1409220
tgctagtctg acaacagctg tatcttcatt gtaattggtt tctataggga cttaacttga   1409280
gcaacgatat tctctaccgt aaatccataa ttatcaatca cagtctgagc tggggcagac   1409340
gcaccgaaga tgtcaatacc gatgaccgcg ccatccaaac caacatactt gtaccaactt   1409400
tgggtcgctg ccatttcaat ggccacacga cgacgagtct tagatggtaa aatgtcttcc   1409460
ttgtaggtag catcttgagc atcaaatagt tcggttgagg gcatagatac cacacgtact   1409520
ttaccacctt gtaaaaccaa ttccttagca gctttgatag ctagattgac ctcagatcct   1409580
gtagcaatga taatagtatc aaatcccggg gtatcataca cgacgtaggc tcctttagcg   1409640
accttaccaa agtctgtccc ttcttcaact accaagtttt gacgggttaa gacaatgaca   1409700
gttggagtgg tggtactggt caaggcatga tgccaagccg cttgagtttc acgggcatcc   1409760
gctggacgga taacagtcaa gtttggcatt gagcgtaaac ctgccaaatg ttcaactggt   1409820
tcatgagttg gaccatcttc accaacggca attgaatcat gggtaaagac ataagttaca   1409880
ggcaactcct gaatggctga tagccgaata gcagctttga cgtagtcaga gaaaacaaag   1409940
aaggttccgc cataaactcg taaaccacca tgaagagcca ttccattgag gattgttccc   1410000
atggcaaatt cacgtacccc aaactgaata ttgcggttta atggattata tttatcttgt   1410060
aagccatctg ccttgatgta ggtcatgtta gagtgagcta agtctgccga tccacctaag   1410120
aaggttggta aaactgctgc tgtattaata gcatcttggg acgaattacg agttgcttga   1410180
gagaagccat tctcatagac agggaagtct ttttcagtaa tggttacagg ggattttcca   1410240
gctacaatag cgtcaatctc actagcaact tcgggataag caaccttgta atcagacacc   1410300
aaactagccc aagcatcgta tgcctcctga ccacgatccg ctacatttgt cttgaaatca   1410360
gaatatactt cctctggtac ttcaaatgga tcgtaatccc atcccaaaaa cttacgagtt   1410420
gctcctgttt cttctgctcc tagtggtgca ccatgaacag catttgtacc acttttattg   1410480
ggtgagccgt aaccaattac cgttttcact tcaatcaaac tcggtttacc agaaaacttg   1410540
gccgtctcaa ttgctgtaga aattgctgct aaatctgttc catcttctac cagaactgta   1410600
tgccaaccat aagcatcgta acggacgcga acattttcag agaaagtatc tttggtctca   1410660
ccatccaagc agatgtcgtt ggagtcgtag aggacgataa gcttatctaa agcttgatga   1410720
cctgcataag aagccgcctc cgcagacact ccttccatga agtcaccgtc tccagcgata   1410780
acataagtat aatggtcaaa aatagggaaa ccatctttgt tgtacttagc agctaaaaaa   1410840
cgctctgctt gggcgaaacc aacggcagta gaaatcccct gaccaagcgg accagatgtc   1410900
gcatccacac cagacgtatg cgtcacttca ggatgaccag gtgtcttaga tccccattgc   1410960
cggaaatttt taatctcgtc catggataca tccttatacc ctgttaaatg caagagagca   1411020
tacagtagca ttgatccatg acccgcagac aagataaagc gatctcggtt aatccagttt   1411080
ggctgctcag gtgtaattct aaggtgcttt gtaaataggc tataagccat tggcgcagca   1411140
cccatgacaa ttcccgggtg accagaatta gatttgttaa tagcatctac gccaagaaaa   1411200
cgaatggcgt taactgattg tagtgacata tattcctcct aactaataaa tttcttctca   1411260
aaccattatt tgattggcat tgtttttccg gtcatttctt cgtaatctct agaacagata   1411320
tcccaggctt tggcaatatc gtcatccaaa ccaaataatc cactgcgacc tataacataa   1411380
atatctggtc ctgccacatc aatttgtttg aaagtcttac gactcgaaga accatccatc   1411440
tcaatgatgt agtgataacc attctgaact ctaagctgac ggagttcttg gattttatac   1411500
aaggtagact ccaaaaagcg ttgtcctgca aaacctggat ctacagtcat aatagttgct   1411560
ttgtcaagta aatcaatgta gggaaagatt gtagaaacag gtgtttcagg attaaggaca   1411620
acaccagcct ttagacctgc atcatgaatt ttatcaatca aacgaaaagc aagaccattc   1411680
agaacttcag catgaataca aatatactca cattgtaaat cgagaacttg atctacccaa   1411740
aaggttgggt ctgtgaccat cagatgaact gataaaggtg tgtcactaat tttttgaact   1411800
tcttgaatga accaaggaga caaggtaata ttgggaacaa aatggccatc cataatatcg   1411860
atatgataag atgctacttt atcattcaaa aaagtaatct gctctttgaa tttgtccaaa   1411920
tccatggtca tcaaagatgg tgaaaattca attcttgaca tcgttaccct cttacaaaat   1411980
ttcaatatct gacaaatcaa tctcttcttc aacagtcata actggttctg catgttttat   1412040
tggttttttc aaaatcgcgt agacaagtcc tgtgactaca atgttagcta acaaggcaca   1412100
aataccagct actggacgag tcatggttgg taacataagc actccaccaa atggcacagc   1412160
agaatcagca cccattgtca aagaaacagc accaccaaca gcaccaccga tacctgttgc   1412220
aatgagacct ggaaccaagt tattcataac aatcggaatt acaccttcaa caatattgac   1412280
aatccccata ggaacagccg atttcaatgt ttcgatttcc tcttgagtat agatattttt   1412340
tttgagtaat ttcgcgataa aataggccaa tccaaatcca actggtgtag cagtattcac   1412400
caattgtaaa gcagtcaatg gttctttcac accttcagcc tgtaaagtca acacaaacgc   1412460
atagactgtt ttattaagtg ggccaccaaa gtcaacagca ctgagaattc caataactgc   1412520
ccccatcaaa ccatttgaag cacttcccaa gctttgtaat aagctcgtca accagttggt   1412580
aaaggctgcg ataggcgctc caataatata aatcataatc aaactactta ccaaagaggc   1412640
tacaaaagga ataatcaagg ttggcattaa acctttaatc cagtttggta ctttgacctt   1412700
tttaataatc gcttgaacca agaaaccagc tatataacct cccaagatac caccgataaa   1412760
ccctgaacca acagaattgg caattagacc aacaacaaaa cctggtgcaa tccctggctt   1412820
accagcaatc gagtaagaca aacctgtagc aataacaact ggcaagagac caagggcttt   1412880
accacccata gttgctaaag catcccagat agtgaatttt cctgctacaa gagcgtcagg   1412940
aacaccaccc cccattgcta aaccaatggc aactaagaat cctgcaccac aaacaattgg   1413000
aatcatatag gaaatggctg tcaataagtg accttttaag tttaagtgtt tcaacatata   1413060
ttttctcctt aaatattttc agttatttcg taacaatctc aacagcttta gcaatcagtt   1413120
tattgggaga tttgactgcc acttctgttg gaaccttgat aatcttttta ccctcaaagc   1413180
gttccatacc agaaatctta acatcaactg ctaaaataac tacatccgct gcatcaatct   1413240
gctcttgact caattcattt tctaccccta ttgtcccctg agtctcaaca tgaatcacat   1413300
gtccagctac ctttgcggca ttctctaatt tttcctgtgc aatataagtg tgggcaattc   1413360
ccacagtaca agctgcaaca ccaacaattt tcatacggat accctccaaa attttttctt   1413420
attaacaaaa agctgcaatc acatcatcag atgtctgagc ccgaactaat ttggcaacaa   1413480
cttcgtcatt accaagtttt cgagcaaaga gtgataaggt cttcaaatgc tccctagcag   1413540
cttctgtatc atcaccaact gcaaagagta caattacttt gacccctttc ccatcaatgg   1413600
tctcccaagg aatctcattg tgatttatag ctatgactac ccccgccttc tccacagcag   1413660
aactcttgct atggggaata gcaatataat tcccaatacc ggtctgtcct tctgcctctc   1413720
tctgataaag accttcgata aattggtctc tatcagacac ataacccgtc tcaaccaata   1413780
gttgagctaa tgcctcaaaa acctcttctt tgctctgcat ctgtaaatcc gtctggatca   1413840
gactcacatt aagaatatct ttgatttcca tatattatct cccgtaattc ttcttttgtt   1413900
aactgtttta attgatttat gaatgattca tctgctagtc ttctcatcaa tgttttaata   1413960
catgacttgt cctgtgatac tgcaatggcc aaaccgataa taaggtcaac acactggata   1414020
tccttcgacc attctctgat aggtgatttt aatctagtaa tcactaagac atgatgttga   1414080
aagtttcctt cacaatgtgg tagaagaaca cctttagcaa cctctatact tccctgtctc   1414140
tcacggtaat atagaagctc ttctattttt tctgtatctt cagaaacaag aaggctgatt   1414200
tgatttgcta attctttgta ggcttcttga cgattttgaa cagatatatc cataaggaca   1414260
agcgaaagat tattcatagt ttatctcctg aatttttgct tgaagacgtt gtttatcacc   1414320
ctcggttaga aaaacactaa ctaggacaaa cgggacactt gctggttcct gcaaagctac   1414380
cgtcgtcaca atgaaatcta aatctggata tagatttatc agctcatcta attgatgata   1414440
agcaactaca tcaataatat ccaattcaga aaattgcttt tctaatcgtg ctcgtaaaag   1414500
ctctgaagtt ccgacacctg atgtacacat cactactgtt tttagaggac gtgctcgctt   1414560
ttcttgaaac cgtgcaaaat ataagactag aaaaccaatc tcgtccagac tcaaggaagc   1414620
aaaaccaaat actagactca cttctttaga aatagttgtt aactctttaa ccagattagg   1414680
ataggttaaa agaatttgtg ataaaagact attcttaatc tgtactctat tatctaatct   1414740
cctcagtaag ggactgatat gactcgccaa gtcaacaaag tcaggatctg tcgtttcaat   1414800
ctctctattg tccatacaca tacggctaaa atagtaatga gtgacatcta aaactcgctg   1414860
agaaaaagga agcttcccgg aagaaaatgg tttttgcaat ctcgaagata caacgtattg   1414920
ataaagatag tcaatctcaa ctgcatcaac cttcatccta aaatattgtt caatttcttg   1414980
aataattttt tgacagacac tgtaaatttt ctcatcaaca atagtaggtt ttgaaggtgc   1415040
tacaacatga atactagtac tacgacgatt cctactgata aaaatataca ggtgagagaa   1415100
aatatttata ttatatggat agggaatgtt tacccccaat tctctctcaa gtgtaatcag   1415160
taatcccaaa caaaagtgag caagttctcc gtcaagaggc tgaaccttat tctgtgtaat   1415220
ttgctctaaa tccaactgat taaacattgg cagtagattt agaatggctg aacgaatttg   1415280
agcctcatcc ccatcaataa aaagctttcg ttgtctcatt tttaaatcta acccataaat   1415340
tgctagactc tcttgtaata tctgacgatc ttttagtact actgactcgc ttacgtagaa   1415400
ttcctctcct aaatcataaa tagaatgtgg cttaggagca gtcaacaaga gacgttctag   1415460
taatttttca cgccttactt caggatcaaa agcctctgta aaattcccat caacgtccac   1415520
gagggaactt cttggattta atttgaaacc tctgcctttt tcagataaaa tgaatgcttc   1415580
taccggacaa tctttgttga ttcccttgac aaggcgataa accgttttat cagagcaatt   1415640
taatttttct cccaatactt tagcagatat ataatcctta ctatctcgca aaaggagcaa   1415700
caacgtttcc atttgttctt gttttctaga cacgatacac ctcctttatg aatccattat   1415760
atcgctttca aaaaataata tacttcgcat tttgtccttt gcaatggaca tttttgtttt   1415820
tatcaaaaat atgatatcaa atagaacaga acctcactat gccaaaatca ttttaccttt   1415880
tcttcataac atctatttta gttgaaatat ttaagttgct tttcgtattt gataagaaat   1415940
aaaccaaacg attttctaat aaataacact atgttccatt taacaataga tagcatcttc   1416000
attttcaaac taccaaccta tccgaccatt tgttctagca atagaagaga gttaaaatta   1416060
cttcaatctg tcgctttctc tttcttacat caaacttcaa atagtctaac tacagatatt   1416120
tgaatctatt acctcaatcc aagcaggctt gagggtcgct cttgggttca ccgatagatg   1416180
atcggcacgt aggccttgca catcagatct acgatagatc catcgtataa aaaactgcaa   1416240
tccacagatt gcagtctttc ttgttgtctc ccgaaaacca ctagctatgc tagtggttcc   1416300
atagagcttt tagcgtggta acaaaaagaa cctcctaaaa tgataagata gaagtggttt   1416360
ctccgccact acaacatatc atacaggagg tacctcatga gagaggataa tcaaagttta   1416420
tcacatacca catggaattg taaatatcat attgtttttg cacccaaata tcgtcgtcaa   1416480
atcatttatg gcagatacaa agctagtatc ggaagaatca tacgtgactt atgtgagcgt   1416540
aagggtgtaa taatccatga agcgaatgct tgttcagacc atattcacat gcttatcagt   1416600
attcctccga aacttagtgt ttcgtccttt atgggctatt taaagggcaa gagcagtttg   1416660
atgatttttg ataagcatgc gaatttaaaa tacaaatatg gcaatcgcaa gttttggtgt   1416720
agaggctatt atgtagatac ggtaggccgt aatcagaaag tgatagctga atatattcag   1416780
aatcaattac aagaagacag agtagcagac cagctcacgt tattcgagtc agtagatccg   1416840
tttactggcg aaataaataa gaggaagtaa ctaaggtgct ttagcacctg ctcgggaaag   1416900
tggtgcgcga ggaagctatt tcggtgggcc tttggccctg gccggtagaa gcggcttata   1416960
gccgcagaac aaaccaccag ttcacactgg tggttttgat ttattttttc gcttggtaac   1417020
gactggtcag gatgaaaatc acggtaaaga ccaacatcat gacaccataa acaggcaacg   1417080
tttgttctgt taaggttgaa atttcaagca gtttttgaat tcttgggaag agagctgtgg   1417140
ctaggaaacc tcctactgac caaacaatca agaggacacg ccatagggta aatggcatgc   1417200
aggctctaaa tacggataag aaaccaattg accccaagag ataatagagt agagttgaga   1417260
tttctaactc agaccaacct tgactcgcgc caaacatttt cacaaacagg acgctgaaga   1417320
cgaccatgag agcgcttggt agggcacgaa gcatggattt tctgaggaaa ttctgctcaa   1417380
caggtttgat atttcgctca aaagtcagaa cgaatggtgg gaaaccttcc acaaactggt   1417440
caatcatggt aatctggatc ggaatgaagg ggaaaatcaa aatccactct gaccgaccta   1417500
gtaaagcact ggcaatacag atgactgcta acaggaagga atagatggtc tttatcaaga   1417560
aaatcggggc gatgtgggca atgttattga ccacgcgacg accctcgaag agaatctcag   1417620
gaacatcatt aaagtctgag ttcaagagaa ccagattggc aatctgacgg gttgctggat   1417680
ccccctccgc catcacgata gaacaatccg cctcacgaag ggccaagata tcattaaccc   1417740
cgtcccctgt catagccgtt gtatgtcccg cttttttcaa cgtttggatg atgagtttct   1417800
tttgatgagg ggaaacacgt ccgaaaatag ctgtctcctc cgccatggcc atcaattcct   1417860
catcggtgat ttttgagcaa tctacatagc tgtgatagtc cgcaaaacca gccttctggg   1417920
caatgctgga caccgtaact ggattgtcac cagagataat cttgagtccc acctcctgag   1417980
aacggagata gtccagcgtc tctgctgctc cctctcgaat ggggtccaag atttccagca   1418040
aggctagagc ctgaatatca gatggtttct gtggtttgtg atggtctaat ttctcctgac   1418100
tgagagctaa gaccaagaca cgtgatcctc tctccaaggc ctccctagct tctgggactt   1418160
cagaatcaag caacatctca ggtgccccta agaaaactgt ccccaagcct tctaactcca   1418220
tagcccccca cttgcggtcg ctcgagaagg gaagattgga aatcatagga taagcaacat   1418280
ctcccacaaa acgctggcga atggcttggg cagttggatt cttatcctca ctatgggcca   1418340
tgtagctagt caagatgctg gcaatagcct cttcaccata cgtttccgtc aacggaagaa   1418400
cagcctccac ctgcatcttt ccttgggtga tggtacccgt cttgtccaga cagagcatat   1418460
ccacgcgcgc caaggtctca acagagtaca tctcctgcac caagaccttt ttcaagccca   1418520
acttaatcac tgcagtcaag agcgaagtaa tggtcaaaag ggcaattccc ttaggcaaca   1418580
ttcccaaaag agctgtcgac gagtttacaa cggatgactt gagaggcagg ccttttaaaa   1418640
gcaaggcttc cagcaagaga gccagaccaa agggaatgat aatcttccca gtaaaaccag   1418700
ccaacttgtc cagcgatttc atgatacggg agttgatggg tttaacggtc ttagcctcaa   1418760
gcatgagttt ggcagcatag ttgtctgcac cgacatggtg aacttgagat aaaactgacc   1418820
cactggctag gaaacttcct gacaaaagta agccgtcaac ttccttttgc accaaatcac   1418880
tttctcccgt taacatggct tcattgactt ccgcaaagcc ttccaaaacc aaggcatcac   1418940
taggaatctg ctctcctgca gacaaacgaa tgacatctcc tagcactaat tcttcaggat   1419000
taagagcaac ttcctgacca tcacggatgg ttttgacctt ttccttggtc atgagattga   1419060
gcttgtccac catgtgtttg gctcgtagct cggtcacaat cccagaaaaa gcgttaaagc   1419120
agataacagc aaagaagacc agattgctcc aagcctgcac aaaggcaaga gccaaagcaa   1419180
tggcaaagtt caaagcgtta aaaagggtaa agacatttcg tttaacgatt tgccaagtgc   1419240
tggtactggc tgatgcggta aagtcattga ccaaaccctc agcctgtctt tccttgactt   1419300
ctctttgggt taatcccata atcttatttt tatccataaa ttctattata tcattttttt   1419360
taacagaatt ctaatttcat cctaaatatg tatctagtca agggaaaagt ttgccagccc   1419420
tcctttgata aggtataata ataacaagaa aacaatcgaa ggagatcgca tgttttatac   1419480
ttatttgcgt ggattagttg tattgctctt atggtccatc aatggcaatg ctcactatca   1419540
taatactgat aaaattccta atcaagatga aaattatatt ttagttgcgc ctcaccgtac   1419600
ctggtgggat cctgtttata tggcctttgc gaccaagcca aaacagttca tctttatggc   1419660
aaaaaaagaa ctctttacca accgtatctt tggttggtgg attcgtatgt gtggcgcctt   1419720
tcccatcgac cgtgaaaatc ccagcgcctc agccatcaaa tatcctatca acgttctcaa   1419780
aaaaagtgac cgctctctca tcatgtttcc aagtggtagc cgccactcaa acgatgtcaa   1419840
ggggggcgca gcactgattg ccaaaatggc caaggtccgt atcatgccgg ttacctacac   1419900
cggtcccatg actttgaagg gcttgattag ccgtgaacgt gtcgatatga actttggaaa   1419960
tccaatcgat atctcagata tcaagaaaat gaatgatgaa ggcattgaaa cagtcgccaa   1420020
tcgtattcaa acagaattcc aacgtctgga cgaagaaacg aaacaatggc acaatgataa   1420080
aaaaccaaat ccactctggt ggtttatccg catccctgcc ctcatccttg ctattatcct   1420140
cgctatccta accatcatct ttagctttat cgcaagcttc atctggaacc cagataagaa   1420200
aagagaagaa cttgcataga agaaatgaac cttggccaaa cagctaaggt tttcatttat   1420260
atagtagatt ggaactagaa tagtacacct ctacttctaa aacattttta gaaatcgatt   1420320
tgactgtcct gatcgatttg tcctattctt atttcatttt actatattta taagaatctc   1420380
ctaatcaaat caaaagccac tctacaatag agtaacttta agattgtcca tttatactca   1420440
atgaaaaagc cctctgaaaa tcagagagct gatttgagct cgggctaaaa tcctagtgaa   1420500
acaaaaaaat ctacacgatc agaaaagtct ctatcgtgcc attttcatac atgatgtata   1420560
gtccaagtag aatgaatact aagggcacaa tgattcgctc gtatttttca attgtctcga   1420620
atattaacgg aatagaggat aacacccgac taatctcgca aaagataatt atgccgatta   1420680
caaacacaag caaggccacg agggtctgtg accaatctaa cgaagcaaaa taaggtatat   1420740
agatacctaa attatctccg ccagacgcaa ttgtcagcaa tgtaactgtc caaaacagtt   1420800
gatttgcctt gctttgttct aatctttcaa taatttcttc ctcttcttct tccgcatctt   1420860
ctccaacaat tgcaaagcga atccctaaat agatagggat taaaccaagc aatccaacca   1420920
tccattcttc aggcacgaaa ttaacgacat aagcagcaac taaactcgcc cctacaagta   1420980
agcctgtgcc tagatattgc cccgcataaa tatgccattt ctgtttattc tgtgatagct   1421040
gtgcaaataa aataattaaa ataattaaat aatcgatact ggtggaaata taaacaccaa   1421100
tagcagatat gattgtctgt cccataaaaa aaacctcctg tattagtcag taataaatca   1421160
gcagatttta ggagagcaca gacacattaa tttagctatc gctagtgggt aatatcgaac   1421220
gtaggaaagc attttactcc tcctcaaaac gtagttacaa agtaatttct aactggaatt   1421280
cagtgactac ttccatgtaa agtataacat actatacttt actttgtaaa gagtgggctc   1421340
ttctaggggg cttgcataca gctactcggc ttgaaaagcc gagtaactgc gcacctttat   1421400
ggtgtaatta gctgataccg tttgaggttt ttgtagtctc caaaattgtt accgataaaa   1421460
cctcaataaa aaagccctct gaagtcagag agctgatttg agcccgggct aaaatcctag   1421520
tgaaaaagat gaaactcctt gtgctcatcg aacactgtgt catttcccta ttttcatacg   1421580
gatttttgac gcccttagca tcatgattct tgctagataa atcgtttata gactaggcga   1421640
cgaggcgaag atcgtacgaa actttcagtg aaacaaaaaa aatctccccg aagggagaaa   1421700
agctggttta ttttacctta cagtgctagg aaccgtaacc aaagattata cttgagtata   1421760
tcgaggtaag gtgacaacgc aaaaaagcta cccaatttag agtagcttta ttatcaagat   1421820
atgctcaatt gaacacggcc taagcacttg gcaaaaaaga taaaatctcc tagaaactga   1421880
agtttcttcg tcaattttcc tatttttgct ttgtgctttt gacggccttt gtatcttgaa   1421940
ttagcgacga agtcctagag agttgatcaa ctcacggtaa cggttaacgt cgtttttacg   1422000
caagtatgca agcaagttac gacggcgacc gatttttttc atcaatccac ggtaagtagc   1422060
gtggtctttt ttgtgttgtt tgatgtgttc gttaaggtgg ttgatttccc aagtaaggac   1422120
agcaacttga acctctactg aacctgtatc accttcgtga cgtgcatatt gtgcgatgat   1422180
ttcatttttt ttctcttttg agattgccat gatgtttctc ctttttattt ggcttcatcc   1422240
gagtgacagg ttggcatgcc tgtaaccaag aagaagttat ttgtctttac gacaatccct   1422300
attttaccaa gatttaaatt ttctgtcaaa cattaatact ctcatagtta ttatttttca   1422360
agtaaagaga tacgttcttt tatatgatga cctttttcaa gttcatctac caatccaata   1422420
gcataatctg cataactaat ctggcttatt cctttttcat tagtagtaaa aatttctcct   1422480
gctagaatgt agtttcctgt tttttcacca tcgggaataa aatctacagc aggactgaca   1422540
aaagtccagt tgagattatt ttttgtacga agaagatcca attcatccgc ttgagctttt   1422600
gctagtggct taaattcttc aggaaaatca ggcgtatcta aaagtcgtgt cgtttttgtt   1422660
tcatctatat aaagacttcc tgctccccct acaactagaa aacgtgtctg tgttccagca   1422720
agaagctgat taaatagttc gattgatttg ctgtggagcg gtagcgtatc tggtgtataa   1422780
gcaccaaacg ctgaaataac agcatcaaat ccagtaagat catcttttgt caactcaaat   1422840
aaatcttttt taataataga ctcagcttga cttttgtttt cagaacgaac aatagccgtt   1422900
acttcatgtc ctcgtttgac tgcttcttca acaattgctt tccccgcttg tccatttgct   1422960
gcaataactg ctagtttcat tttttatacc tctcttgttg taattatttt agttacagaa   1423020
attgtgacac tcttaataat caatgtcaat agtcttgctt aattattatc aaaatatttc   1423080
taccaagaaa actaaccatg attctagtga aaaaaaatct tctttgtcaa caaatttact   1423140
ttcttgtttt aaacatgcta taataatcat agcaagagat ctaagttgtc tgttttttta   1423200
aaacgaggtg attatcatgc gtagattcta ttcccatctc ccctactatc tggtcatatt   1423260
attcttttat tggccacttt atgagttgtt cttactagtt gtttctgacc cccttacact   1423320
caagggactc tatataaaca atcttctctt ctttacacct ctggtaatct tgattgtatc   1423380
gttactctat agctaccgtt tccgtttctc actttgatgg ttagttggta acggactgct   1423440
cttttacttt actatcataa cctttggtga gtttatacta atttacttgc taatctatga   1423500
aacagttgct ctggtcggca tggattctgg tattagcatc aagcatattc tacaaaaaat   1423560
gaaaaacaaa aaactttcac aaaatccttg aaaaatctca caatcatgct ataataatcc   1423620
atagagacaa gtcacttagt ccctttctac tagagagtgc gtggttgctg gaaacgcata   1423680
ggaagtctaa actgatacta ctcttgagtt ttttatgaaa acataaaacg gtggccacgt   1423740
tagagccgat cagaggtgtc cctctctttt gaggtacata aatgaaggtg gaaccacgtt   1423800
gcgacgtcct ttcgaggatg tcgcattttt ttattaggat actaattatg gagttgcaag   1423860
aattagtgga gcgcagttgg gcaatccgac aagcttatca cgaactggaa gttaagcatc   1423920
atgattccaa gtggacggta gaagaagacc tcttggcttt atctaatgat attggaaatt   1423980
tccaacgact ggtgatgaca aagcaaggac gctactatga tgaaacaccc tacacactgg   1424040
aacaaaaact ttcagaaaat atctggtggc tattagaact ttctcaacgt ttggatatag   1424100
acattctgac ggaaatggaa aacttcctct ctgataaaga aaagcaattg aacgttagga   1424160
cttggaagta gtctgctgat aaaaaatcaa tgcttagaaa ctatgaaata ataaaaaagg   1424220
agaacatcat gattaacatt actttcccag atggcgctgt tcgtgaattc gaatctggcg   1424280
taacaacttt tgaaattgcc caatctatca gcaattccct agctaaaaaa gccttggctg   1424340
gtaaattcaa cggcaaactc atcgacacta ctcgcgctat cactgaagat ggaagcatcg   1424400
aaattgtgac acctgatcac gaagatgccc ttccaatctt gcgtcactca gcagctcact   1424460
tgttcgccca agcagctcgt cgtcttttcc cagacattca cttgggagtt ggtccagcca   1424520
tcgaagatgg tttctactac gatactgaca acacagctgg tcaaatctct aacgaagacc   1424580
ttcctcgtat cgaagaagaa atgcaaaaaa tcgtcaaaga aaacttccca tctattcgtg   1424640
aagaagtgac taaagacgag gcacgtgaaa tcttcaaaaa tgacccttac aagttggaat   1424700
tgattgaaga acactcagaa gacgaaggcg gtttgactat ctatcgtcag ggtgaatatg   1424760
tagacctctg ccgtggacct cacgttccat caacaggtcg tatccaaatc ttccaccttc   1424820
tccatgtagc tggtgcgtac tggcgtggaa acagcgacaa cgctatgatg caacgtatct   1424880
acggtacagc ttggtttgac aagaaagact tgaaaaacta ccttcaaatg cgtgaagaag   1424940
ctaaggaacg tgaccaccgt aaacttggta aagagcttga cctctttatg atttcacaag   1425000
aagtgggaca aggtttgcca ttctggttgc caaatggtgc gactatccgt cgtgaattgg   1425060
aacgctacat cgtaaacaaa gagttggttt ctggctacca acacgtctac actccaccac   1425120
ttgcttctgt tgagctttac aagacttctg gtcactggga tcattaccaa gaagacatgt   1425180
tcccaaccat ggacatgggt gacggggaag aatttgtcct tcgtccaatg aactgtccgc   1425240
accacatcca agttttcaaa caccatgttc actcttaccg tgaattgcca atccgtatcg   1425300
ctgaaatcgg tatgatgcac cgttacgaaa aatctggtgc cctcactggc cttcaacgtg   1425360
tacgtgaaat gtcactcaac gacggtcacc tattcgttac tccagaacaa atccaagaag   1425420
aattccaacg tgcccttcag ttgattatcg atgtttatga agacttcaac ttgactgact   1425480
accgcttccg cctctctctt cgtgaccctc aagatactca taagtacttt gataacgatg   1425540
agatgtggga aaatgcccaa accatgcttc gtgcagctct tgatgaaatg ggcgtggact   1425600
actttgaagc cgaaggtgaa gcagccttct acggaccaaa attggatatc cagattaaaa   1425660
ctgcccttgg aaaagaagaa accctttcta ctatccaact tgatttcttg ttgccagaac   1425720
gcttcgacct caaatacatc ggagctgatg gcgaagatca ccgtccagtc atgatccacc   1425780
gtggggttat ctcaactatg gaacgcttca cagctatctt gattgagaac tacaaggggg   1425840
ccttcccaac atggctggca ccacaccaag taaccctcat cccagtatct aacgaaaaac   1425900
acgtggacta cgcttgggaa gtggccaaga aactccgtga ccgcggtgtc cgtgcagacg   1425960
tagatgagcg caatgaaaaa atgcagttca agatccgtgc ttcacaaacc agcaagattc   1426020
cttaccaatt aattgttgga gacaaagaaa tggaagacga aacagtcaac gttcgtcgct   1426080
acggccaaaa agaaacacaa actgtctcag ttgataattt tgttcaagct atcctagctg   1426140
atatcgccaa caaatcacgc gttgagaaat aagagtctag cataaaagcc tccaatctgg   1426200
aggctttttc tcatctattt ttactcaagg actaagttca cttgagcaaa ctgaatccgc   1426260
actgtcgttc cttttccgac ctcagactcg atacgaatct ggtgccccag ttcttcagaa   1426320
attttcttag atagataaag gccaagtcca gaggactgct gggtcaaacg gccattgtat   1426380
cctgaaaagc cacgttcaaa tactcggagg acatcactgt tttttatccc gattcccgta   1426440
tctttgatac aaagctcttg gtcatccata taaatctcca gaccaccttc cttggtgtac   1426500
ttgagactgt ttgagatgat ttgctcaata accactagca gccacttttt atccgtcacg   1426560
atttctttat caaggtcatg tagattgaca tttaagcctt tttgaataaa gaaaagagca   1426620
tatttacgaa ttatttcctt gaccaagtcc tcaatttgaa cctgctttaa gaccaaatca   1426680
tcatggaaac tttctaaacg caggtactgt aaaactaggt tggtatagga gtcgattttg   1426740
aaaatttcct gttctagctg ctgcttcagt tggcggtcga ccacttctgc aactaagagt   1426800
tgactggctg caatgggggt ctttatctga tggacccaca aggtatagta atccagcaaa   1426860
tccgtcagtt ttctttctgc ttttgacctc tgctgataga gttccatctc acgcgcttct   1426920
aatttttctg ctaaagctat ttccaaagga gacttggctt ccctctctcc atagagaagt   1426980
tcctggcgat agacctgcgt ttccaccaat atgtcccaag tgaaaaataa tatggttaca   1427040
aagcaacaca agaagaaaaa gtagaggaag taaattccta gactggcaaa taaaaactga   1427100
aagagtaaga caagaaatgc caaagaaagc agatagataa aaagacgact acgggagcgc   1427160
agataggcta gaaaaaattg tttccaatca agcatgcttc aatccgtacc ctattccttt   1427220
cttggtctcg ataaatccta ccaatccctg ctcctccaac tttttacgca aacgagccac   1427280
attgacagag agggtattat catcaatgaa aaagtcactg ttccaaagtt cccgcatcag   1427340
gtcgtcacgt gctacgatgt tgcctgcatg ctcaaataac acgcgtaaaa tctggaattc   1427400
attcttggtc aaattcaaga cttgcccttg ataatgtaaa tccatggatt tggtattgag   1427460
gataacacca gcatattcca gcaaactctc atcacgccca aactcatagg aacgacgcaa   1427520
caagccctga accttagcta aaagaacctg ctggtcaaaa ggcttggtca caaagtcatc   1427580
cgcccccata ttgattgcca tgacaatatc catagcctgg tctctcgaag aaagaaacat   1427640
gataggtacc ttggaaatct tgcggatttc ctgacaccag tgataaccat taaacaaggg   1427700
caaaccaata tccatgagga ccagatgagg ttccgactga acaaatagac tcaaaacttc   1427760
cataaagtct tctaccagga ccacttcaaa tccccattca gagagcattt tcccaatctg   1427820
ttgacgaatg acctgatcat cttctattaa taaaatcttg tgcatgcgct tctccttttc   1427880
cattattata acagattttt ccatgctaga tggtctgaaa ctgaatttga aatagcctgt   1427940
ttttagccag tacaaacagg ctatgctact agctaatttg agggaaattt gctaagataa   1428000
ataaaaagaa aggagctctt atggccaata tttttgacta tctgaaagat gtcgcatatg   1428060
attcttatta cgaccttccc ttgaatgagt tagacattct aaccttaata gaaatcacct   1428120
acctctcctt tgataatctg gtctccacac ttcctcaacg tcttttagat ctagcacctc   1428180
aggttccaag agatcccacc atgcttacta gcaaaaatcg ccttcaatta ttagatgaat   1428240
tggctcaaca caagcgcttc aaaaattgca aactctccca ttttatcaac gacatcgacc   1428300
ctgaactgca aaagcaattt gcggctatga cttatcgtgt cagcctcgat acctatctga   1428360
ttgtctttcg tgggacagat gacagtatca ttggctggaa ggaagatttc cacctgacct   1428420
atatgaagga aattcctgct caaaagcacg cccttcgcta tttaaagaac ttttttgccc   1428480
atcatcctaa gcaaaaggtt attctagctg ggcattccaa gggaggaaat ctcgctatct   1428540
atgctgctag ccaaattgag caaagtttgc aaaatcagat cacagcagtt tatacatttg   1428600
atgcacctgg tctccatcaa gaattgacac agactgcggg ttatcaaagg ataatggata   1428660
gaagcaagat attcattcca caaggttcca ttatcggtat gatgctggaa attcctgctc   1428720
accaaatcat cgttcagagt actgccctgg gtggcatcgc ccagcacgat acctttagtt   1428780
ggcagattga ggacaagcac ttcgtccaac tggataagac caacagtgat agccagcaag   1428840
tagacacaac ctttaaagaa tgggtggcca cagtccctga cgaagaactt cagctctact   1428900
tcgacctctt ctttggcact attcttgatg ctggtattag ctctatcaat gacttggctt   1428960
ccttaaaggc gcttgaatac attcatcatc tctttgtcca agctcaatcc ctcactccag   1429020
aagaaagaga aaccttgggt cgccttaccc agttattgat tgatactcgt taccaggcat   1429080
ggaaaaatag ataatactct tgaaaattaa atgtatacaa aacaaaagac ctagaataca   1429140
tactttcatg tgcattctaa gtctttttaa atagaatcta atagtcaata aaaatcaaag   1429200
agcattgaga gataatgggg cttggaacgt ccctctcgct tcaacaaaat gaccccatta   1429260
tagattaaaa agatgccact tagaaaaagc aaaaaaggaa gtaagacaaa ggcaaatata   1429320
taaaaagcta actgaacatt ctcgtatcca tttttataaa aaaggtagga tagataaaaa   1429380
taacttgaaa tgagggataa taaaaataat actggattcc acaaacttct attatccttc   1429440
caaaatgaca ctataaaggc taatacaatt cctataacga gatacatttc ttactccttt   1429500
aatagctaca ttttatcata attatccaaa gaaaaaagag ggcatttatc cctcttaatc   1429560
cttcatctga ctctctgcat cggccacgac tttttctaga ctggtttgac caagttctgc   1429620
ctccatagtc aactgaattc tctccaattt ttgatccaaa acatcatgaa tatgagctcc   1429680
tacagggcaa tttggattcg gattgtcatg gaaactgaag agttgacctg tcttaccaag   1429740
acattcgacc gcctgataaa catctaaaag actaatatcc ttaaggtcct tgacaatctc   1429800
tgttccgccc gttccacgcg ctactgaaat cagctctgcc ttcttcaact gggacaagat   1429860
ctttctgata atgacaggat tgaccccgac actagcagcc agaaaatcac tggtcacctt   1429920
gctttccttc ccctcgaggg caatgattat cagcatatga gtcgcaatgg taaatctact   1429980
tggaatttgc atcctcttct cctttttacg aggctaccct gcctctactc ttctttttct   1430040
attattatac cctttttagt tgtaatgtca atcgttacca cttttcaacc agtcgtctaa   1430100
ctcccgatcg cagccctctt tctgagccaa ttctctcaaa aattcctgat gatgagtatg   1430160
gtggatccca ttgaccagac tttcatagta aacctcaaaa tagggaagtc tcaggtcttt   1430220
agccagctgc aattcagctg ctacatcgta gtctacccgt cggaagtcca tatctaccag   1430280
gcctttgtca tcaaactcca aaatcatata ctgggcccgc aagtccttcc gtagctgagc   1430340
gtccaaaaag aaaggttggc caatcgaacc cggattgaca atcaattgcc caccagtccc   1430400
gtaacgaagc aactgctggt gaatatgtcc ataaacagca atatcacagg gaggatgagt   1430460
caccaagcgg tcaaactcct cttgtttgcc agtatgaatc aactctcgcc cccagttctt   1430520
atcaggcaga tgatggctaa ttcccaccgt caaatcccca aactgacgat gaatttgaag   1430580
aggttgattg tggagcactt caatttcttc tagggaaatt tcctctaaaa catactggca   1430640
ctggcgcaag agatagcgtt gactggggcg agtactgtcc aattccttac ggacaccatg   1430700
ccaaagactg tcttcccagt ttcccaaaac tctagccgta atcggtagtt gatccaacaa   1430760
gtccaaaatc cttctacgcc ctgtccctgg catgagaata tctcccaaaa gccagtattc   1430820
atccactcct atctgccgag catctgccaa aacagcctcc aaggcggtgg tatttccatg   1430880
aatatctgaa agaagagcta ttttcgtcat atccatctcc tcgttttttc tcttgcaata   1430940
agtataacat aaaaagtcac agctagagaa atctagcttt ttttgatata ctagataaag   1431000
atattagaca agaggaaacg aatgacccca aacaaagaag actatctaaa atgtatttat   1431060
gaaattggca tagacctgca taagattacc aacaaggaaa ttgcggctcg catgcaagtc   1431120
tctccccctg ccgtaactga aatgatcaaa cgaatgaaaa gtgaaaatct catcctaaag   1431180
gacaaggaat gtggctatct actgactgac ctcggtctca aactggtctc tgagctctat   1431240
cgtaagcacc gcttgattga agtttttcta gttcatcatt tagactatac aagtgaccag   1431300
attcacgagg aagctgaggt cttggaacac actgtctctg acctgttcgt ggaaagacta   1431360
gataaactgc taggtttccc taaaacctgc ccccacgggg gaactattcc tgccaaggga   1431420
gaactactcg ttgaaatcaa taacctccca ctagctgata tcaaggaagc tggcgcctac   1431480
cgcctgactc gggtgcacga tagttttgac attctccatt atctggacaa gcactcactt   1431540
cacatcggtg accagctcca agtcaagcag tttgatggct tcagcaatac cttcactatc   1431600
ctcagtaacg acgaggattt acaagtgaat atggacattg caaaacaact ctatgtcgag   1431660
aaaatcaact aatttctcaa gtcccctacc aaccctgaaa gttttatttt ggctctttgt   1431720
caactgtagt gggttgaagt cagctaagct cgagaaagga caaattttgt cctttctttt   1431780
ttgatattca gagcgataaa aatccgtttt ttgaagtttt caaagttccg aaaaccaaag   1431840
gcattgcgct tgataagttt gatgagatta ttggtcgctt ccagtttggc attagaatag   1431900
tgtagttgaa gggcgttgac aatcttttct ttatctttga ggaaggtttt aaagacagtc   1431960
tgaaaaatag gatgaacctg ctttagattg tcctcaatga gtccgaaaaa tttctccggt   1432020
ttcttattct gaaagtgaaa cagcaagagt tgatagagct gatagtggtg tttcaagtct   1432080
tgtgaatagc tcaaaagctt gtctaaaatc tctttattgg ttaagtgcat acgaaaagta   1432140
ggacgataaa atcgcttatc actcagttta cggctatcct gttgtatgag cttccagtag   1432200
cgcttgatag ccttgtattc atgggatttt cgatgaaact gattcatgat ttgaacacgc   1432260
acacgactca tagcacggct aagatgttgt acaatgtgaa agcgatccaa cacgatttta   1432320
gcacacggga aaagttgtct agctaaatca tagtaaggac taaacatatc catagtaatg   1432380
attttgacgc gacatcggac ggctctatca tatttaagaa agtgatttcg gatgacagct   1432440
tgtgttcttc ccttaagaac agtgatgata ttgagattgt tgatgatatt gagattgtta   1432500
aaatcttgcg caatgaagct catctttcct tttgtaaaag catactcatc ccaagacata   1432560
atctcaggaa gacaagaaaa atcatgttta aagtgaaagt cattgagctt acgaataaca   1432620
gttgaagttg agatggaaag ctgatgggca atatcagtca tagaaatctt ttcaattaac   1432680
ttttgagcaa tcttttggtt gatgatacga gggatttggt gattcttctt gacgatagaa   1432740
gtttcagcga ccatcatttt tgaacagtga tagcacttga atcgacgctt tctaaggaga   1432800
attctagtag gcataccagt cgtttcaaga taaggaattt tagaaggttt ttgaaagtca   1432860
tatttcttca attggtttcc gcactcaggg caagatgggg cgtcgtagtc cagtttggcg   1432920
atgatttcct tgtgtgtatc cttattgatg atgtctaaaa tctggatgtt agggtcttta   1432980
atgtctagta attttgtgat aaaatgtaat tgttccatat gaatctttct aatgagttgt   1433040
tttgtcgctt ttcattatag gtcatatggg actttttttc tacaataaaa taggctccat   1433100
aatatctata gtggatttac ccactacaaa tattatagaa cctttatttt cagggtttta   1433160
tttctatcat tttattttac tttcatttgg tgggagaata tttgaaaaaa agaaaggtag   1433220
tttaacctat gaaaaaatca ctaaaaattt ttgctacatc taaatagttt gacctcttcg   1433280
gggttgcttt ggtcgttggg attgcgattg catctggtta cctcaactca cacctcgata   1433340
aatttgtaga ctggggatca tggacagctc ttgtaccctt tggattgatt tccgtaacca   1433400
acgttgggat ttccatgttg tccactcgtt tcacggggaa attaagcaaa tggggaaatt   1433460
actttggtat tgttaatacc attttgtccg gtgctattga ttatatcctt ggaaataagg   1433520
cggccatcat tacctatccc gtcaccttcc tcatttatac ctttgctata aagaagtggg   1433580
aagcttcgca agaaggcaga cccaaccaaa tgagccaaaa acaggtaaaa ttggcggcca   1433640
tcatcatttc catcatcgcc ttcctctttg cctttgtgac caactatatc ggatatgggg   1433700
gcaagatgaa tctccttgcc tacgtaacaa ctattgcctt tgcactgtcc ctcattgcca   1433760
atgctttgaa tgcattaaaa ctaacaactc agtggggctt ttggttgatt tacaatttcg   1433820
ttcagctgac aaaagctggt attcaaggaa acttcgccaa tatcggtaaa tacatctttt   1433880
atatcctcaa tgcaatcgga gctttatttg tctggaatga tgaagaagtt agataataga   1433940
aggaaactca aataaagaat actagccaac ttaagagaat ctcccttctg ctatttttat   1434000
cattttagtt gtaactccca ttcttttgga gtagaatgaa gttagataaa agagggaggt   1434060
cttgtcatga aaaaactcta tagaatccat tttatagcaa ttgcagttat tgatttgcta   1434120
ctatttgcat tttttatcac tagactcgag acatcttttg agtggctctt gctctctggt   1434180
ttaattttct tccttgctca aggactcctg ctatttctct tggtcgtccg actcaaacat   1434240
caattcgctg agatttatcc tcaaatcaat aaaaagattc gcttctacta tttaggggtt   1434300
ctcaccattg attttctatt ttttgttctc ttagccttca ttagttctca gcgtttttca   1434360
tctcttatgc caatcatcac tgcttgccat tctacttttt attatatgac agctgactac   1434420
ctaagagaaa actatccaga cttttacgac aaacacatct ctttatggga gtgtctctaa   1434480
agaaaaggag gttttagcat gaaaaaaatc atcttcatca aaaccattca actccttgtc   1434540
attgatggaa tcatgctggc atttttgaca tttaaaaggg ggcttacttg ggactggatt   1434600
ttgatttata gcggttggct cattttcttt catcctgtgc tattgaccta tctttcaaac   1434660
caactttgtg accactttag ttaactctat tcccagatta gaccgagatt ctggcgtttt   1434720
gctttacaaa ttctcctatg ggatagcctg atgattctct ccttggtgtc tttaagtgat   1434780
attccacttt tccttcaggg aactctcctc atcctaggac atctcatccc ttcctatcgc   1434840
atctgccaaa gcctgaaaag agacttcccc caagcatatc aagaaccgat ttctttttgg   1434900
agtattttat gatagatgag aaagaccaag ccgactgggc ttggtctttc ttatctcttt   1434960
ttagtatcta ggataatggt aacaggtcca ttattaacca gctcaacctg catatctgct   1435020
ccaaagatgc ctgtctgaac gggcacttct tgcgctaatt tttgattgaa agcatcatag   1435080
aagtctgatg ccatatcagg tttagctgcc cctgtaaagg ctggacgatt gcctctctta   1435140
gtatccgcaa agagggtaaa ctgagaaata gagaggattt ctccttcaat atctttgaca   1435200
gacaggttca tcttgccttc tgcgtctgaa aaaatccgca tattgaccag ttttctcaca   1435260
gcatagtcca aatcttcctc ttggtcctct ggtccaacac caaccagcaa taaaagtccc   1435320
tgattgattt ttccctgaat ctggccttct atactcactt gggctttttt aacccgttgg   1435380
ataatgattt tcataatagc ctttctagta agagctagga caactagccg ttggtccgtt   1435440
tgacagagta aacttctggc acactcttaa ttttatcgac aaccgtggtc agtgtagaga   1435500
ggttggcaat accgaaggac acatggatat tagcaaactt catatccttg gttggttggg   1435560
cattgaccgt tgaaatattc ttggttgtat ttgaaagaac ttgcagtaca tcgttcaaca   1435620
gtcctgtacg gttgagaccg tagatatcga tatgggccat atactcctta tttgagctag   1435680
ggtactggtc ttcccattcc acatcaagga gacgttgctc gtagttttct tgggcacgca   1435740
ggttcataca gtccacacgg tgaatagcca caccacgacc cttggtaatg tagccaacaa   1435800
tatcgtcacc aggcacgggg ttacaacact tagcaatccg cactaggaga ccagaagcac   1435860
cttcaataac cactcccccc tcatgcttga ccttgagggt ttctttattt tcaaccttga   1435920
cctcgccacc tttgacaagc tcctctgcct cagctttggc cttggcacgc tcttcctcac   1435980
ggcgttcctt ttcagtcaga cggttaaaga cggtaatcgc accgatttcc ccaaaaccaa   1436040
tggccgcaaa gagggagtct tctgtcttgt aactggtctt ttgcagaact tgatccatgt   1436100
ggcgcttgtc cataaattta tttgccacat agccattttc ttggaactga gccatcagca   1436160
tctcacgacc cttgttgaca gacaattcct tatcttggtt tttaaagaac tggcgaatct   1436220
tattgcgcgc cttgctagtc ttgaccatat tgagccagtc acggctaggt ccaaaggagt   1436280
tcgggttggc gataatttca acctgatccc ctgtctttaa cttggttgtc agtggaacca   1436340
tgcggccatt gaccttggca ccagttgctt tttcaccgac cttggtatgg atttcgtagg   1436400
caaaatcaat cggtcctgaa tctttgggaa gggaacggac agctccatct ggggtaaaaa   1436460
cgtaaatctc ctcagccaaa tagttttcct taacagagtc cacaaattcc ttagcatcat   1436520
cagcctggtc ttggagctcc atcatctcct tgatccagtt cattccaata gctgattcct   1436580
tgctgttaac ttgccccttt atacctttct tataagccca gtgagccgca accccgtact   1436640
cagccacctc gtgcatttcc ttggttcgaa tctggaattc aatcggccct tttggtccat   1436700
aaacagtcgt atggatagac tgataaccat tggccttgcg gttggcgata tagtctttga   1436760
agcgacctgg catcggtttc caaaattcat gcacgtaacc aagcatggca taaacatcac   1436820
tttgggtatc taaaatacaa cgaatagcaa tcagatcata gatttcctca aaccgttttc   1436880
tcttgtcctg cattttgcgg aaaattgagt aaatatgctt gggacgacca taaatcttcc   1436940
ctttcaagtg acgttctgtc gtatactcct ctaattttgt gactacctca tccaccaagg   1437000
cctcacgctc cctgcgcttt tccttcatca tatgggtaat cttgtaaaac tccgttggat   1437060
tgagataacg gaaagacaag tcttctaatt cccatttgac actggaaatc cccaaacgat   1437120
gggcaagcgg ggcatagatt tccatggttt ctttggaaat acgctcctgc ttgtcttttc   1437180
gaagatgttt cagggtccgc atattgtgca agcggtcaga cagtttgacc aaaataacgc   1437240
ggatgtcctc agacatggcc atgagcatct tgcgatgatt ttccgctaat tgctcctcga   1437300
tcgatttgta ctcgaccttg ccaagcttgg taactccgtc aacaatcatc cgcacatcag   1437360
gaccaaactc tctttccaaa tcgtccaaag tcgcatctgt atcttccacc acatcatgca   1437420
agaatccaca agctactgtt acagcatcca gctttagctt agctaaaata cctgccactt   1437480
ggatagggtg aatgatataa ggctcgcctg atttgcgata ttgaccactg tggcattcaa   1437540
cagcatagac caaggcctta tggacaaaat gaacatcctc ttccgttaaa tattctttgg   1437600
ttaaagcgac aacttcttcg cctgttaaat tcacttcttt cggcatctct actctccaat   1437660
tcttcctacc attttatcac ttttttaaga atatgaaaac tagattggaa cagaataaga   1437720
aaaaaataat tcaaaattgc ttgataattc tgaattattg gtccgtaata tactacgaag   1437780
ttagatttta aacttaggtg atagaaggag agatagaaga acggaaacca tattgtaacc   1437840
caaagacttt ctgacttccc caattccatt gaagatacga aagataaacg gtggaactcg   1437900
tatcacatac actggtacct tgactggatt ttggaattaa tactaaatga aaatcaaaga   1437960
gcaaactagg aaactagccg caggttactc aaagcaccgc tttgaggttg cagataaagt   1438020
tgacgcggtt tgaagagatt tttgaagagt ataaaaatcc tcaagatact ttcttctatc   1438080
ctttagttta taaggagaat acctatgaaa aaaactgcta tttctatctt tgctctccta   1438140
atgttaggag tttgctgcct gttcctattc agccagcaaa gctataaaaa acagtcgttc   1438200
aatactatgc taacgaccag aacctgccca gtaggataac ttatagtgaa tatagcgaca   1438260
aatgagaagc caactacggt agcactctaa acatcacgtc tatcaaacaa gctaatgacg   1438320
gagtttatgc aacctatgaa gggcaattga cacctttcca atattgataa attgataacc   1438380
agcctgtctt catctagtca tgctggtttt taagttcatt ttaaatcctt acctattctc   1438440
cctaactgtg ctatacttaa tttatactca atgaaaatca aagagcaaac tagaaagcta   1438500
gccgcaggct gttcaaagca ctgctttgag gttgcagata aagttgacgc ggtttgaaga   1438560
gattttcgaa gagtattagt acattctttg agattggagc tagtatgaaa atccataaaa   1438620
ccgtgaatcc tgttgcctat gaaaatacct attatctaga aggcgaaaag cacctcatcg   1438680
tcgtcgatcc tggtagtcat tgggaagcca ttcgtcagac aatcgagaag atcaacaaac   1438740
cgatctgtgc tattctcttg acccacgccc attatgacca tatcatgagt ctggacttgg   1438800
ttcgcgagac gtttggcaat cctcctgtct atatcgcaga gagcgaagcc agctggctct   1438860
acactcctgt cgataatctc tccggtctcc ctcgccacga tgatatggca gatgtggtca   1438920
caaaacctgc agaacacacc tttgtctttc acgaagaata ccaactagag gaatttcgtt   1438980
ttaaggttct accgacccca gggcactcta tcggtggtgt ttccctagtc tttcctgatg   1439040
ctcatctagt cttgacggga gatgctctat tccgcgaaac tatcggacgg accgaccttc   1439100
cgactggtag catggagcaa ctccttcata gtatccagac ccaactcttc accctaccaa   1439160
actacgatgt ctatccagga catggtccag ctactactat cgctcacgaa aaggccttca   1439220
atcccttttt ctagcaagat gatgacaatc gaaatttaag taaactatcc agcaaatctt   1439280
tctattacaa aaggcatcct atcaaggttt tcacacatga ttggatgcct tttttctgat   1439340
gactagattt tttgcattac caaataatca cgcgctcctc tggtgaacgc cacattccgt   1439400
ctccttcttt gacatcatag gttgtaaaga aatcgtcgaa gtttggtact tgcacattga   1439460
cacggagttt ggctggtgcg tgcacatcga cgctagccaa aagtttcata aattctggtc   1439520
gacctttcat gcgccagatg cgaccgaagt tgtagaagaa ctcttctgct gagaagtctg   1439580
cttctctctt agctgcttca agcgctgctg cgattcctcc caagtcagcc acgttttctg   1439640
atacagtcaa tttaccgtta atggttgctc cataagaatc ctgtccatca aattggtcaa   1439700
tgactttttg tgttttctcc ttgaaggcag catagtcgct ctctgtccac caatccttga   1439760
ggctaccatt ttcgtcaaag gaagccccgt tagtatcaaa ggcgtgggaa atttcatggg   1439820
caatcactgc cccaatacca ccgtagttag cagaagatga ctgatgcaag tcatagaaag   1439880
gcgcctgtaa aatggccgct ggaaagacaa tcaggttctt ctgaggattg tagtaggcat   1439940
tgaccatatg agcaggcatg ccccattcct tataatctac aggctggttc cacttactcc   1440000
aactgtgctt gatttccaca cgcgcaaagg ctagagcatt ctcaaaaaga ctggcagttt   1440060
cattcactac cttatccttg taacgtgcag gcaattcttc tggatagcca atataaggtt   1440120
tgatcacatt gagcttcacg atagcctgtt tacaggtttc tggagtgagc cagtcattct   1440180
taagcagacg ctccttataa acatcaatca tggttgccac ttttttctcc acatccgcct   1440240
tggcttctgg agagaacttc tcacgggcgt accaaagacc cagggcttgc ttgaaaggtt   1440300
cttgtgctag atgataagct gctttgacct tatcttttgc ctctggaact ccagaaaggg   1440360
cacggctgta ggcaccagac aaaacacgga tatcctctgt taaatagctg gttgaaagat   1440420
tgacaacact caaaatcaag gttgctttaa ggagagacca ggcttcctca ctgtagaatt   1440480
gctctgctgc ttgccagaaa cgttcctcgt ctacaataac cttgtctggt aattgcccaa   1440540
taactgcttt gaagaagtca tccaaaggta gggcaggcgc gaatttcttg aaatcttcgt   1440600
aagaatatgg atgatagagt ttagcatatt ctgaactttc ttcattagag agcaccactg   1440660
ccgcaactcg gcggtccaat tcaagtcttt tttctagcaa gtcttcaatt tcttcatcag   1440720
agaaatcata agccttgagg agatttgcgc tgctttcttt ccaaagagtc aagagctctt   1440780
cgcgctgagg atgttcttct gcatagtagg tcgtatctgg caagattgtg cttggagcgc   1440840
tagcccatag aacattgatt ctagcatcca taaagtctgg cgatacacca aaaggaagga   1440900
agtttggttt tcctgcaagc tcaaactctg ctagtttagc tgtaaaatcc gcaaaagtct   1440960
ccaattcttg gaattcttta aggagtggta agacaggtgt gataccgtca gcttctctct   1441020
tgtcaaaatc acgaactagg cggtggtatt tgacaaagtt ttccaagata gcatcctcag   1441080
gcacttcttc acctgctaac cacttgtctg ttgtcgccag catcaggtct tcaatttcct   1441140
ggtctaaatc aacaaaacct cctgtttgag acttatctgc tgggatttca gctgtctgtt   1441200
gccattctcc attgatagca tcataaaaat catcttgata acgtgtcatc ttgttctcgc   1441260
tttcatttgt atttgcattt atcttaacaa aaatcactag ggaatgcaat taataaccat   1441320
ttaactatta ttttttagct attataaaaa atctttccat gataaaacgc ataattccaa   1441380
gttttttaca cttgatacta tgcgttttat aatttagaaa tttatcctga aagttatctt   1441440
tagaatctat ttttcagtta ttattttaat tttttcaaaa attaacttga cttaattttt   1441500
tttttaatgt atattaagag acaggaggaa tacaagttta tgatacgtat cgaaaacctc   1441560
agtgtctcct acaaagaaac gttggcactt aaggatattt cactagtgct ccatggacca   1441620
acaattaccg gcatcattgg tccaaacggc gctgggaaat caacactatt aaaaggtatg   1441680
ttgggaatta tcccacatca aggtcaggca tttctcgatg acaaggaagt taaaaaatcc   1441740
ttacaccgaa ttgcctatgt cgaacaaaaa atcaatatcg actacaactt tcccatcaag   1441800
gtcaaggaat gcgtctcgtt aggactattt ccctctattc ctctctttcg aagtttaaag   1441860
gctaaacatt ggaagaaagt gcaagaggcc cttgaaatcg tcggcctagc tgactacgct   1441920
gaacgtcaaa ttagtcaact gtctggaggt caattccagc gggtcttgat tgccagatgt   1441980
ttggtgcagg aagccgacta tatcctcttg gatgaaccct ttgctgggat tgactctgtc   1442040
agtgaggaaa tcatcatgaa tacgctgaga gatttgaaaa aagctgggaa gacggttctc   1442100
atcgttcacc acgacctcag caagattccc cactacttcg atcaagtctt acttgtcaat   1442160
cgagaagtga ttgcctttgg tccaacaaaa gaaactttta ccgaaaccaa tctaaaagaa   1442220
gcttacggta atcaactctt tttcaatgga ggtgacctat gattgcagaa tttatcgatg   1442280
gattgcaaaa attccatttc ctacaaaatg ccttgataac agctattgtc gtcgggattg   1442340
tagctggagc tgtgggatgt ttcattattc tacgcgggat gtcactcatg ggagatgcca   1442400
tttcacatgc tgtcttacca ggtgtagccc tatccttcat cttgggcctt gacttcttta   1442460
tcggagccat tgtctttgga ttgctagctg ccatcatcat tacctacatc aaaggaaact   1442520
cgattatcaa aagcgatacc gccatcggca ttaccttttc ttctttctta gccctcggta   1442580
tcatcttgat tggtgtcgct aaaagttcaa ctgacctttt ccatatcctt tttggtaata   1442640
tcctggccgt ccaagatacg gatatgttta ttactatggg tgtgggggca gctatcctct   1442700
tgttaatctg gattttcttc aagcaactct tgataacttc ctttgatgaa ctcttggcta   1442760
aagccatggg aatgcctgtc aatttctatc actaccttct catggtactc ctgactctcg   1442820
tgtctgtgac agccatgcaa agtgtcggaa ctatcctgat tgtagccatg ctgattaccc   1442880
cagctgcaac tgcttatctg tatgctaata gtctgaaaag tatgattttc ctttcctcaa   1442940
ccttcggagc tactgcttca gttttgggac tctttattgg ctatagtttt aatgttgcgg   1443000
caggttctag tatcgtgctt acagctgcta gtttctttct cattagcttc tttatcgctc   1443060
ccaaacaacg atatttgaaa ctgaaaaata aacatttgtt aaaataaggg gcaaagccct   1443120
aataaattgg aggatctaat gaaaaaatta ggtacattac tcgttctctt tctttctgca   1443180
atcattcttg tagcatgtgc tagcggaaaa aaagatacaa cttctggtca aaaactaaaa   1443240
gttgttgcta caaactcaat catcgctgat attactaaaa atattgctgg tgacaaaatt   1443300
gaccttcata gtatcgttcc gattgggcaa gacccacacg aatacgaacc acttcctgaa   1443360
gacgttaaga aaacttctga ggctaatttg attttctata acggtatcaa ccttgaaaca   1443420
ggtggcaatg cttggtttac aaaattggta gaaaatgcca agaaaactga aaacaaagac   1443480
tacttcgcag tcagcgacgg cgttgatgtt atctaccttg aaggtcaaaa tgaaaaagga   1443540
aaagaagacc cacacgcttg gcttaacctt gaaaacggta ttatttttgc taaaaatatc   1443600
gccaaacaat tgagcgccaa agaccctaac aataaagaat tctatgaaaa aaatctcaaa   1443660
gaatatactg ataagttaga caaacttgat aaagaaagta aggataaatt taataagatc   1443720
cctgctgaaa agaaactcat tgtaaccagc gaaggagcat tcaaatactt ctctaaagcc   1443780
tatggtgtcc caagtgctta catctgggaa atcaatactg aagaagaagg aactcctgaa   1443840
caaatcaaga ccttggttga aaaacttcgc caaacaaaag ttccatcact ctttgtagaa   1443900
tcaagtgtgg atgaccgtcc aatgaaaact gtttctcaag acacaaacat cccaatctac   1443960
gctcaaatct ttactgactc tatcgcagaa caaggtaaag aaggcgacag ctactacagc   1444020
atgatgaaat acaaccttga caagattgct gaaggattgg caaaataaac ctatgaaaaa   1444080
cgtcattctc acatgagctg gcgttttttc tatgcccata tttccggtca aatcattgga   1444140
aaattccgac tgtttcagct aaaatggaag aaaaaagatt ggagtatcct atggtaactt   1444200
ttctcggaaa tcctgtgagc tttacaggta aacaactaca agtcggcgac aaggcgcttg   1444260
atttttctct tactacaaca gatctttcta aaaaatctct ggctgatttt gatggcaaga   1444320
aaaaagtctt gagtgtcgtt ccttctatcg atacaggcat ctgctcaact caaacacgtc   1444380
gttttaatga agaattggct ggactggaca acacggtcgt attgactgtt tcaatggacc   1444440
taccttttgc tcaaaaacgt tggtgcggtg ctgaaggcct tgacaatgcc attatgcttt   1444500
cagactactt tgaccattct ttcgggcgcg attatgccct cttgatcaac gaatggcacc   1444560
tattagcacg cgcagtcttt gtcctcgata ctgacaatac gattcgctac gttgaatacg   1444620
tggataatat caattctgag ccaaacttcg aagccgcaat tgcagctgct aaagccctat   1444680
agaaaaaatc ctctgtcaca aagagttccc tgctctttga aacggaggat ttttgaatat   1444740
tagtaaatag aagttcaatc agctaaaaat aactacctta ctctacagat ttcagggctt   1444800
ctaacatatc aacctttctc agataataat tgacgaagaa accaagcaag gtcaaaatga   1444860
tgcttactgc tgccactggg attacataga cttcccagcc tacctgcgga taaaagagaa   1444920
tagtcgcagg cgaaatcatt tgaatcaaaa attggtgtaa atagaaacca gctatcagac   1444980
caagtacgat tcccacaagg gacagcacaa tcgtctcacg gtaaatgtag agggtgactt   1445040
cattattatg aaaaccaaga accttgatag tggagagttc acggattctc tcagctacgt   1445100
tgatattggt cagattgtaa aggatgacaa tagctaatag aaccgatacg atgaccaaga   1445160
tggtcatggt ctgattgagt gagctagcga tagagtcgaa gagtcgaatg gctgaagcat   1445220
tttggacaac gctggacacc gcagattgat tcataagcaa gcccgcctga ctttcgatac   1445280
tagttgcact ggtatccctt aatgagacca gataagtgtt ggcttggggt agctgtccgt   1445340
aaagttgctc atagctagcc tgactcatat aaataaagtg accaacgtag ttctcagtaa   1445400
tagcaacgac ctttagttcc ttaccttcaa tttctaaagt ctgcccaacc ttgacacctg   1445460
ccagctgggc gagtttagct gtaataacga tgccatcttt taatgtcagc tcctgctgat   1445520
gatgttgaag atggataaag ggagtcaaat cttccttctc tatcatcata agagtaatgt   1445580
tttgaagacc agctttgcct ttgaaatcct tgtatagcgc tttagaatag attttctggt   1445640
aggctagtat ctcctgccct ttcaacactt ctgctagctc taccttgtcc tgattggtcg   1445700
cactaggatt ttcagagaca agcatctgat actgttggat ttgttgaaac tgtttagacg   1445760
gaactcctgc tacagaagat tggattccca aacctgcaaa gagcagagct acagaacctg   1445820
ccacaccaaa gattgtcatc aacattctct gcttataacg aaagatgttg cgggctgtta   1445880
ccttatgagt aaaactgaga cgacgccaga taaaaccgat acgctccaat aagattttag   1445940
ctcctttgac aggaggttta ggaagtagaa gctgggctgc ttcgtcatga agttccctcc   1446000
aagccaccag ataggctggt aacacactcg ccaacaagct caagacaaaa gctagtaagc   1446060
tataggtcca atagaactga atctgagttt ctcccaccac catgcctttt gtaatgacac   1446120
ttgaaattac actggctagc aaataatgac caagtatact acctagagcc gttccgacag   1446180
tcccagctac tagtccataa aggagaaact tggcgataat atccttacta cgataaccca   1446240
aggccttaaa aatccctgca tgagttcgct cttcgtctac aaagcgagtc atggtcgtaa   1446300
aggtcaccat ggctgctacg gcataaagta ccacaggaaa gatattgccc actgctcgaa   1446360
tactggatga agcattgcta tacataagat agccctgacc acctggcatg gtctgacgat   1446420
tataaacctg ataccttggc tccgccaaat catccaagac ttgctgatgt ttttctaatt   1446480
tttccttttc ttgggctaga ttttgttcag cttgctttag tttgtcctct tccttgccca   1446540
attcctgctt ggcttgggta agttgagcac tagcctgctc tctctgaact tgaggaaaca   1446600
aggctagttg actttcttga gcctgtatac gagcttgagc agctgctaaa cgacgcttgc   1446660
cttcctgcaa attagtctga gccttgtcaa gggtctcttg ccccttgtct agagactctt   1446720
gtccttcttt tttcaaaagt tgcagacgta ccttgccatt atctgataaa atttgttcaa   1446780
gctcttcttg atgttgcttg gatttttctt cataagctga tgaaaaggca tttaaacccg   1446840
ctaaatcttg atatttcaaa cgagctatat tgtagacttt ctgatcaaat tgactaggta   1446900
aaatcacccc ataggctgtc agagtcccac ttccacttcc tgcgtagccc atatctcgct   1446960
gggagaggat ttcagccgaa tccacaaaac cagtaatggt ataagtatgg tcttttaaag   1447020
aggaatgacc ctcttctttt tctttaaaac taatctcctg tcccacgctg tattggcctt   1447080
gcaaatgagt ggccaaagcg atttccttgt ctgactgagg aagtcgtccc tttcttagct   1447140
gaaaggttga aattcgctct ggtttggagt acagccgaat ggcatcctgc ccattatcca   1447200
tagtcacatc tgtcaaatag ccaaactcga cctctgcgcc ctccgtctgt tttagttctt   1447260
cttggtctgc ttgatccaag ccatagttag acatgactgc caaatccaag gtttgagcag   1447320
ttgttaaata agcattagct gtcgcctcca tgttgggact ggttactttg aggcctacta   1447380
aggctagaga tcccaacatc atcaggatca agatggataa aaaacgcccc ttggagcctg   1447440
tgaaggactg aactaagtcc ttccaataag tttttcgctt gatcatgcta gtactccaaa   1447500
ctgtcaatat cctgaggatg ctggttgagc accacatcct tgacactggc atcgtgcatt   1447560
tgaatcacgc gatcagcaat gggcgccaaa gctccattat gagtcacgat gatcaccgtc   1447620
gctccctttt gacgagacat gtcttggaga attttcaaaa cctgcttgcc cgtctgataa   1447680
tccaaggctc cagtcggttc atcacaaagg agaattttag gatttttggc taccgcgcgt   1447740
gcaatggaga ctcgctgttg ctcccctcca gaaagctggg ctggaaagtt attgagacga   1447800
tgagccagac ctacatctgt caaggcctga tcaggattca aggcatctgt cacaatttca   1447860
gaagccagtt ccacattttc cttagctgtc agattagaaa ctagattata aaactgaaaa   1447920
acaaacccca catcatttct acggtaattg gtgcgctggt gggaactata atccgcaata   1447980
ttaacaccat caatccagat ttccccttca tcattggtat ccattccccc aagaaggtta   1448040
agaactgttg acttgcctgc acctgaagca ccaaggataa taaccagctc ccccttttca   1448100
atctcaaaat tcacatcaca attggccaca atctccgtgt ccccaacctg ataacgcttg   1448160
taacagtgtt tcatctcaat ataagccatc agacccaccc tctatcaaac aaattatact   1448220
cctcgaaaat ctctcttcaa accacgtcag cttccatctg caacctcaaa acactgtttt   1448280
gagcaacctg cggctagctt cctagtttgt gctctttgat tttcattgag tattacttcc   1448340
tattatcatt ataacgtttt ttcaactagt tgaaaactgc ttatattctt aaatccttat   1448400
taaaaggcag tttcaaatta ctgccttata acatcttctt aaaaataaaa ttgaacaaga   1448460
tcaccttctg ctgttgccac cgaaatacaa tctttcccca tgcatttcgc ttttattttt   1448520
tcttgattca ttttaatcac actcttctca atatctggat aagaaactcg caaatctcct   1448580
ccactccttg ataaaatggt caactgtaag agttttttat cttcccagct catgctcact   1448640
tcaaaatgtc cacgtgccat taagcctgaa acagaacctg ttgaccaagc atcaggtagg   1448700
gcagctagag gtaccagata agctgcatga gactggagta acatttctgc catgccacta   1448760
gtagcaccaa aattaccatc tatctgaaaa ggaggatggc tacaccaaag attttgcaag   1448820
gtggatgtct ttaactgctc tgccaataat ttatgggctc gattgccatc tcccaaacgc   1448880
gcccagagat tgatcttatt agccttggac cagcctgtgc cgccatctcc acgatcattg   1448940
aggctagcac gcgccgcttc aatatactct tgtcccttgt agctaaagag attgccagga   1449000
tagagtccca ctagatggga agcgtgccga tgctgggcct ccactttctc attttgaaaa   1449060
tactgctctt cctcctcata ccactccctg attcgaccag attgagtgat ttgcaaagga   1449120
tttagtaaat cagacttctc cttaacctca gtcaacaagt cctcatccag tcccaattcc   1449180
tgagcagcct gaataaaatc atgaaataac tgccaaatca gagattggtc ataggtattg   1449240
ccaatcgaaa tcggcccatg ttctggggaa taagacggag aagacaccca acgctgcgcc   1449300
tgctgatcct tatgtaaaaa ggcattccaa aaacgaaccg tttccctcaa catgggataa   1449360
attttctccc tgagatagtc ttggtcccta taaaataaat aggcttcata aacggtttgc   1449420
atcatccacg cattggcagc tggtgaccaa ccccaatagt aatcccaacc aggtgccgtc   1449480
caaccaaagg gagtcgcttg agtatgaacc aaccaaccat tctcctcacc tttctgagag   1449540
acgattcctg catactttac agccgctaga cgaccataga cacgcaaatc atctacatag   1449600
ttgatgactg gaaagaccgt ctctaggaga ttggtaacat aggctggcca ataattcagc   1449660
tgcagattga catttaagtg atagtccgaa ttccaaggag gattgtcgac cgcattccag   1449720
actccctgta ggttagctgg tagagcatct gggcagtctc tggacgaact aatcaataaa   1449780
taccgtccat actggaagaa cagctcctcc aaagcctgcc cttcttgtgg cttataattt   1449840
tttaacaaat catctgtagt ggatgcgtca acatcagctt ccaaatccaa ttgaacacgc   1449900
tggaataagg cttggtagtc ctcgatatgc cttgatttca attgggtata gcccttttct   1449960
ttagctgtgt ccaccaagtc tatcacctgt tgctctaaat ctagtttctt gcgataattg   1450020
ctagcaggat tttgggcaaa atccgtctta gcggccaaga agagattggc ataactggct   1450080
cctgatatct gaaccctatc tgaccaaact ctaatatctc catccgtttc ccaagctaga   1450140
taactagcaa accgcagatc attatcctta actcttccct tcatcaagat atgagaatca   1450200
gtaatatcca acttacactc cttgtaatca gatttttcct gctcatactt tccatcagaa   1450260
gccaaatcac aggtcaagga tagttctata gtaaaatcta gagtttccaa cccttcctta   1450320
gtaaaacatt gaaccaagag atcatctgga aaactcgcaa aagctttacg ttcaaatcgc   1450380
gttcccttat agacataaga agtcgtcgca agtgccttac taatattcag ctgtctctga   1450440
tagtccgtca cctgagacaa agtcgtacct tgctggctga actcaatgtg aatatcccca   1450500
aaagacagat aggtcccata ttgactcgtt tttggcccaa ttaggtgctg ctcagccagt   1450560
tccttagcca gattgtaatc tctcttctcc aaagcctgcc gaatctcagc taaaaaaaca   1450620
tactgatcct gaagatttcc accctgataa tctgaactat caggaagtgg acctccagac   1450680
cagagacttt tttcattaaa ttgaatccgt tcagccccta taaggccaaa tacttttgct   1450740
cctaaagaac cattgcctat cggtaaagct tcttcttccc aacccatgta agtggttgaa   1450800
gctggttgct tgtaggccag tacataatct tgttttttat tccttatcat acttccatac   1450860
taacataaaa agcctagaaa tcaattctag acttacaatt ttttattttc caaggtagta   1450920
ttcagaaacg acgttcaatt tttcgtcgaa ttcgaatacc aatggtggga agttagggat   1450980
ttccacgtcc atgatctcgt catctgacaa acctttgatg tgttttacaa gggcacggat   1451040
tgagttaccg tgagctccta cgaatacgtt tttaccatct ttaagagctg gagcgatttt   1451100
atcttcccag aatggaagag cacgttccaa agtcactttc aagttttcag catctgggat   1451160
aactgagtcg tcaagtgaag cgtaacgacg gtctgtgtga gctgagtgct catcatcacg   1451220
gtccatgttt ggaggcaata catcgtatga acgacgccag atgtgaactt gctcatcacc   1451280
aaattgttca gcagcttcag ctttgttttt accagtcaaa ccaccgtagt gacgttcgtt   1451340
caagcgccat gatttttcaa ctggaaccca caattggtca gaagcttcaa gagccaagtt   1451400
agttgttttg atagcacgtt tcaatactga agtgtaagct tggtcaaatt cgataccagc   1451460
ttctttgatc aatttaccag cgtcaatcgc ttgttgtgta cctttttcag acaaatcaac   1451520
atcagcccaa ccagtgaaaa ggttagcttt gttccattca gactcaccgt ggcgagcaaa   1451580
aaccaatttt accattagat ggattctcct ttaaattttc cgaggtttcc cctcgtttat   1451640
ctattctatt ttacacaatt tttcacaaaa aagctagtca aaaccaaaaa ggaaaggact   1451700
gtttgacaat gtttggcaat cacattgttt ttggttgttt ctattctatc ttcattattt   1451760
aacctttttt tctgcgcatc gaataatttt tgagttgact cttttagttt agtaaacgag   1451820
tcattatttt ccatagctat gcctttgaaa ccttcctcag ctttagtaaa ataatcatca   1451880
aaaatatttt tataaagatc tatataatct gcataagtgc gtattgattc aatcgcatcg   1451940
tctgttacaa ccggtgtatc gaaagtgatt gtttcttttg aactattgga tgttgctact   1452000
gtcttctcat cattacttgt tgaagtattc tttgaacttt atgttccaca tgcaactaga   1452060
agagaaagag ataatagagc tactcctata ccgataaact tttttgttct tttcatgcta   1452120
aaataccttt tattcttctg atttgaattt cttcaatgtt gaaaggaata gagatcctcc   1452180
gataatagca aaaatccccc caacccatcc taagaacgga atagaatgag actaactcca   1452240
ccagaaacaa tcattagtac agacggagct gcacctacac gcttatctcc tttatagtaa   1452300
acaatagcaa tgataccaag aacaagattt gcaatcttca aggcattcaa gagtaaggct   1452360
acacctgaaa aagcccctgc agtagctcct ccattaagag ttgtagcagc tgtgtttacc   1452420
gctattccca acaagacaaa aggaccaata agaagtaaaa ttcctcccac aagaccgacg   1452480
ataccactaa ttaaagcaag tctttttaat tttataataa aatctccttt tttatttttt   1452540
tcaaataaaa ttgtatcata tttgctttta aaaaaagtat gttctgatat tataaaataa   1452600
aaatttgtat aatatgaaat aaaatataat acttttcaga aaccagaaat aactatataa   1452660
atttattgtt gtaaaaatat tacactattt accaatctta tccctaatat caaattccta   1452720
ttttatctta ctactgttag cttgctaagt ttctctttga ttcttgttga gtataaaaag   1452780
tcatacctcg caaattttta aaataaataa aaaacgcatc atatcaggta ttcaaaaacg   1452840
tgatacaatg cgtttaatag actataaaat tagttgtctt ttcttctcaa attgaatttt   1452900
gcctagactt ttcaatctta tttctcttca aatccttctg cgactgcttc cgcaaagttt   1452960
tcttctacga tgcttgcaca gtggtcacag ataactgcct ggtagctgcg ttctgctgtt   1453020
gttgggtcga tacgacggca acggtcacat acttcaccag tagcacgttc aactgtgaag   1453080
gctacatctt cgaagctaag ggcagcttcc ggagctggtc cttctgcgat ggtcaactca   1453140
gacacgatca aaagttgtgc tacattgctg tttactgctt cgagtagagt tttcacaact   1453200
tcatttggat aaactgtcaa gtgtgcttca agtgatttac cgataacttt tgcattacga   1453260
gcttcttcca aggctttttg tgcttgtcca cgaaagtcca tgaaggctgc ccatgtatcc   1453320
aagatttctt cttggttagc aaaagtttga acttctggta attctgacaa ttggacgaag   1453380
tcttctgttt caaactcaag atatgaccag atttcttccg cagtgtgagg aaggattggt   1453440
gtcaagagtt tggtgatttt gacaagaatg tcatagaaga cagtctgcat ttgacggcgt   1453500
tccagtgatt tggcaccttc aatgtaaaca acatctttgg caaaatcaag gtagaaggct   1453560
gacaagtcaa cgttgataaa gttcaccaag gccttgtaga tcgtcaagaa ttcaaagtct   1453620
gcataggcat cacgaatggt cttgacaagc tggttaaagc gaatcgtcat gtacttatca   1453680
actgaacgaa gctcatcgta agcgactgta tcttgagctg ggttaaagtc agatgtattg   1453740
gcaatcaaga aacgaagagt gttacgaatc ttacggtaag tttcagaaac ttggctcaag   1453800
atatccatag agatacgcac gtcattgctt gagtcaacac ttgttaccca gagacgcaag   1453860
atttcagcac cgaattgttt ttcaacatcg cttggagcaa tagtatttcc aagagattta   1453920
gacatcttct cacctttacc atcaagggca aaaccttgtg acaagatttg tttgtaaggt   1453980
gctacgccat ggttggcaac agatgtgata agtgatgagt taaaccaacc acggtattgg   1454040
tcagaacctt ctaggtaaag gtcggctggg taagtcaatt caggacggtt taccaccact   1454100
ccattccatg atgaacctga gtcaaaccaa acgtccatga tatcagtttc ttttttgaac   1454160
tcgccgtttg gtgaacctgg atgagtaaat ccttctggca agaggtcttt ggcatcacgt   1454220
tcccaccaaa tgcttgaacc atattcttca aaaagttgag ctacgtgttc aatagtttca   1454280
gctaccatga tagctgtacc atcttcagcg tagaagatag gaagtggaac accccaagca   1454340
cgttgacgag agataaccca gtcaccacgg tcacggatca tattgtaaag acggacttta   1454400
ccccattctg agtggaattt cactttttca atttcgtcca agatttcttg acggaattta   1454460
gaaactgagg caaaccattg tggaactgca cgccagatga ttggtttctt agtacgccag   1454520
tcaaatggat atgagtgaga gatttcttct tgggcaagaa ggaggttacc aagtttttca   1454580
ataacagttg gaactacctt ttcatagaat tgaccttcaa attcaggacc agcattcttc   1454640
atcatgatac cacgttcatc aacagtcact gcgacttcaa gattattagc aataccaaca   1454700
ttgtaatcgt cctcaccaaa accaggggct gtatggacaa tacctgtacc agagtcagtc   1454760
gtaacgtggt caccaagaat taccaactct tctacagctg tatcccatgg gtgttctgtt   1454820
acgatgtggt tgagttcttg gccacggtaa gtttccaaaa cttgaacatc agcccagcca   1454880
aatttctcag acaagctagt caataattca gcagcaacga caaacttacg agcttcacca   1454940
gcaggttgaa ccaaaacgta atcaatatct gcaccaaccg tcaaaccacg agaagctgtg   1455000
atggtaaatg gagtcgttgt ccagacaacg atataagtat ctgtatctag aactcctttg   1455060
ccatctttta ccttgttggc atagtaaagg gaagttgaaa ccaagtcatg gtattcaatc   1455120
tctgcttcag caagtgctga ctcagatgac catgaccagt aaactggctt agcaccacgg   1455180
tagatataac ccttattagc catctcacca aatacacgaa tttgagctgc ttcatagtca   1455240
ggagtcaagg tcacatatgg attttcccag tcaccagaaa cacccaaacg tttaaaatct   1455300
tcacgttgtt tatctacttg agaaagagcg tactcacggc aaagtttcaa gtactcaacc   1455360
aagtccattt ctttacgttt gacaccttgt tttgacaaga cttgctcgat tggcagacca   1455420
tgagtatccc aaccaggaat aaatggtgcg taaaatcctg acatagactt agaacgaaca   1455480
atgatatctt ttgaaatctt gttcatagca tgtccaacgt ggatatttcc gttagcgtat   1455540
ggagggccat catgcaaggt gaaatgaggt tttccttggt tcaattcttg acgacgttga   1455600
taaagttttg catcttccca ttccttttgc caaactggct ctttggtagg aaggcctgca   1455660
cgcattggga attcagtttt cccaagatta agggtgtctt tgagtttcat ggtatctcct   1455720
ttataaataa taacaaatta aaaaccacga cttccaaaaa ggacgaaaat cgtggtacca   1455780
cctttattcg gaaaaagatt tagtctttct ccctcttatc ccgtaacgtg ggaaacgtca   1455840
aatcttacta gcttcagact tgagtttttg agaggataat cttatcaata gggattacag   1455900
gactcacacc atctcctgct cgctggaaat ataaggataa gatattgttc tcagaatatt   1455960
tcttataaaa ttgtaacaga ttcttgcggt gcttcaaatc ccggtattga atcaacagtt   1456020
tctgtagctg gtgttggacc tatcggatgc attggagcta cttctggttc ttcatacatt   1456080
gggccaactg gatgagcaga ggctcttctt caacttgagg actcactaca ggagttggag   1456140
cttccacttc ctgtttaatc tgagcttcaa attcagacaa ttctttatcg gctacctcaa   1456200
tacgagcttg taattctgcc atttctgctt gagagaactg acgtgtcata tcaattggtt   1456260
cttcttcaat tggagctgga atcggttctc caagtacttc gctaaccact tctttaaagg   1456320
cttcatcact ggtttgaaga taagtagctg ttggacggag aatatcttcc caatctgaag   1456380
attcaacaat agccaactga ctctcaattg tagatttgag acgttggtgg aagacacggc   1456440
tcttgttctt caattcttct gtttcaacag cgactttctt agcattatca gttgcttgac   1456500
gaagaatctc gtttgcctta tatttagctt cttccaacaa gcgttgcgca tcttgctctg   1456560
cttgatgaat gatattgttt gaacgttcat gcgccgcctg tttcactctc tcagctgtat   1456620
cctgagcaat caatacagac tggctcaatg aatcttttat ttcatcaaag taagacaaac   1456680
gctcttctaa actcttaata cgcaaatttt tatcatgatt cgcacgcaca agatcttcgt   1456740
aatcacgaac cacaatatct aaaaattcat cgacttcttc tggatcaaaa cctctgaatc   1456800
gagttccaaa agtcttgtcc tttatttcta atgatgtaat tggcattcta ttcctcactt   1456860
acttaataat aactggacgg ttattttttt cttctctttt ttcgtttgtc ccttatcttg   1456920
aagtaatctc aagcgaccaa attttctcac actaatcaag tctccaactt gaacagtgta   1456980
atctgatttg tctaccacat gataatttac ttggacaagt ttcttttcaa tcaactggtt   1457040
tgcttgattc ctagatagtt tcaaaacatt tgataaaaga acatctaatc gaaaactaga   1457100
cacagataaa tccagttctc gatactgttc tagcttatct attttctcgg tgaaaggacg   1457160
ttcctccagc gaaacaggta tacgaccaat tttctttagt ccatcttgaa agagaagaag   1457220
aaactgctga ttaatcataa tctgcgcccg ttcttcatct actaggatat ctccaaaaag   1457280
tttccgttca atccctaatt gattgatgac tgtccctaaa atcttagcat gcgttaaatg   1457340
ttcaaattta ttggaataca caatttcctg gagagatatt tcaaaatctg aaaactctgg   1457400
ttggaaataa tctgggtata ataaaactcg aacatactca ctcgagacga attccccact   1457460
actgctacaa gcaagaccat aggttttggc caaaatcttt aatagcttct cctgatgagg   1457520
attgataaaa ggagttaaaa aaggagcata gctatcttct accttcttta tccattccat   1457580
tcccttgtca agaaatggac gatcttctat ggagaaatgc tgataaatcc ctttattcat   1457640
cctatcatcg ccagaaaacg cactaggttt tctcctaaaa atcgaaccaa aacaatcgca   1457700
acccaaacag ataaatcaag acccgctatc tgtaaaggca ggcgttgcaa gggagcaagc   1457760
actggtttca ccaacgctac aatccaacga cctaaactgg attcgtaggc acctggaaac   1457820
caagacatga cagcgaaggc taccaaaatc agggagtaaa tatccactgc attataaatc   1457880
atacgaatta aaaaaatcat tatcgtactc tatttcgctt catatcaaaa ccgaactcac   1457940
cctgttgatc ttcatctggt aaacggatat cttcaacatt tacaataacg ttcactggtg   1458000
tcaacaaata catggtagaa gctacctttt tcaaatttcc agctaaaaca tgacaagctc   1458060
catccaaata gtccaaacaa cgacgagcct gcacctctgt catatactga aaatcaatca   1458120
agatactttc gtttcctgcc aataaatcaa caatttctgt tgcatcctca tattttctag   1458180
gataacgaac atctataatg accttatccg ttgcacgctg actctgattt gccaattcct   1458240
gttgtcttgc atgaagtctg gtgatattgt tctcttttgt gccagccgac tgtgaaggtt   1458300
gattcattgg gagagccggt tcctgtgaag aatttactga agtaaacaca ggctcatctc   1458360
ttttttcata agggagactt gaatcctcat cctccgtaaa ataatctata aatctatcga   1458420
atctatcttt taaagacatg gttctctcct acttaaaaaa tgatgtacct atacgaacaa   1458480
aagtggaacc gaattgaatc gcttctttat aatcacgact cattcccata cttaactcgg   1458540
tcataggcat atttggaatt tgtttctctt gaatttctct ttgtaaatct tgggccgcct   1458600
tgaaaatctc tttcaactgc tcactgctag cctcaaaagg tgccatcgtc attaaaccaa   1458660
catattcaat cttatctagt ctggctaact ctggcaagat ttccagcagt tcctctctcg   1458720
aaaaaccgtg tttgctttct tctttagaaa tatttacttg aaggaaacac ttgatgactc   1458780
ggtcacttct tttttgaatt tcccctgcta gctttactga gtccaatgca tggaaataat   1458840
caacgtattg aatgacatct ttcaccttac gtctttgcaa ggtaccaatc aaatgccaag   1458900
tcacatctcg atcttttaaa gcttcatatt tttccagaaa cttatctaca cgattttcac   1458960
cgatatgatg gacacctagc ggaagcaagg cttccgctgt cggtacatct acatacttgg   1459020
taactgcaat gacagagacc gaaccactct ctcgatgagc actcagacta gcctctgcaa   1459080
cttctcgaaa aacaagttct gtattttctt ttacattcat ttacttaacg atttttgaaa   1459140
aatggaggtg tatccaattc atcttcatct tgtgaaattg gggcttcaaa gcgctcgact   1459200
ggagaaacga ctgaatctgt tgtacgaaca atcgattcac ggcgaagatc ccaatcacca   1459260
aaagcagatg cctgagttgg ttccaaacga cgtggatttt gttttggcaa ttcaactgtt   1459320
tctgccatat caaaatgacg atcaaagcca tgtgaatgag ctggtttcac tgtctcacgg   1459380
tagttagtag cagatctagc ttgtggagcc acaacctttt ctacgcggtc ttgacgaaca   1459440
cccgttgcaa caactgttac acgaatttca tcacgcatac tttcatcaat tgaagtaccg   1459500
agccagatgt tcactccttg acctgctgcc tggttcacaa tttgtgaagc ctcttctgcc   1459560
tcaatcaagg ttaagtcaag accaccagta acgttgacga taacatcctc agcaccgtca   1459620
atagttgttt caagaagtgg tgaatagatt gccttacgtg ccgcttctac cacacgttct   1459680
tctccactac cgataccaat acccataaga gcattccctt tgtttgccat taccgttttc   1459740
acatcggcaa agtcaaggtt aatcaatcct ggattggtaa tcaaatcggt aatcccttga   1459800
acaccttgac gaagaacgtt atccgcttcg ctaagagcct ccaaaagcgg tgttttctta   1459860
tcaacaattt caagcaaatt gttgtttgag ataatcaata gagtgtctac atgctcacga   1459920
agttgattga ttccttctac agcaaattgt ccacgcttac ttccttcaaa accaaaggga   1459980
cgtgttacaa caccaactgt aagcgcacct aaatctttgg cgatacgagc aataacagga   1460040
gcagctccag ttccagagcc tcctcccata ccagcagtga tgaagaccat atcggcacca   1460100
ctaatagctt ccgtcagtgt ttcttcgctt tcttcagcgg ctttacgacc aacctcaggt   1460160
tgacctcctg cacccaaacc acgagtcaat ttaggtccca actgaataac agtctcagct   1460220
tttgtactac tcaatgcttg tacatctgtg tttgctgcga taaattctac gcctgtaaca   1460280
ccttcgtcga ccatacggtt gatggcattg ccaccacctc caccgacacc aattacttta   1460340
atcactgccc cttgagcagc agctgtatca aatgaaaatg tcataattta tttttcctct   1460400
ttattcgtca aacatgcttc cgatcaatcc acggaaacga tctgctaatt tcggtttatt   1460460
ttgtgaagct tgttggaaat ccgccattgg ttctgtaggc gccaccggct ctacttctgg   1460520
agcaggagct ggttgaacag gcgttgattg tacaaactga gctgtttttt gcagcatccc   1460580
accaaaacta attggctgat gacttaagtc attctcacct tttatcgctc cctgagccaa   1460640
aagattaact tctgttaatt gacccgcaaa ttctgataaa ctaatcacat gcgcaaaggc   1460700
tggattacgg ataccaactt gatttggaac ataaagcttg acacggacgc caaagacttc   1460760
ctgagcaagc tcaaccatac ctggtaaaat ggcattccca ccgattaaga caataccacc   1460820
agggaggtcc aatagacgcc ttctatctaa ttcttgcttg atttgttcaa ggatgtgctt   1460880
gattcgtgca gaaataattt ctgacaagta ggcttccgtc acttcgactg cttctacttc   1460940
tccaataacc tctacttgga aggtttcttt gcttgcaaga ggcggatagg cttccccgta   1461000
attcagtttc aagccttccg ctaatttgcg agaggttttc aaaaccttgg agatatcttt   1461060
agttacataa tctccacctt cttggagaat atgtgtgaac tggagttctt gattacggat   1461120
tgtagcgaca gtcgtttgac ctgcccccat atcaatcact gtagcaccaa attcacgttc   1461180
cccttcgttc aaaacagact gaaccattgc tagtggtgaa atgataacat tttcaacctg   1461240
aacacctgca cgctcaaccg tcttacgcaa attgtgcaag atagtacgag gtcctgtata   1461300
aagcaaacca cgcatttcaa ggcgaacccc catcatgcca cgtgggtcac gaatcccttg   1461360
gaaaccatcc acaataaatt cttcaggaat aaaggtaatg acttcacggt caggtgtcat   1461420
actctttgtc aaagctgatt tgacaacatt ttcaacatct tgatccgtaa tttccttagt   1461480
atcagatgtt actggaatca tcccctgagt tggttctacc tgcaaaagat taccaggcaa   1461540
gccgacattc actgatttaa tcgaaatgcc tgccttttct tccgcttggg aaatggctga   1461600
cttgatagca gttgctgctg catcaatatc aacaataatt ccatccttta cacctttact   1461660
tttggcatta ctcacgccaa ttacatttaa ttcaccattt ctctgctcgg ccacaagcac   1461720
cttgacagag cttgttccaa tatctagacc tgtaaaaaag ccttctctag ccattacatc   1461780
gcttcctctc tatcttccaa gtttcgcact tcgtattatt ccatagctaa acataggcat   1461840
agctattcac aaaatattat aacacaaaaa atttaatcgt gcttgctttt ttcctaaatt   1461900
tcccagccat tttttgagtt tgtctattca gaaattctta ttttataagc tgcttgtaaa   1461960
aactctctaa gagcaaaaaa gaaagctctg tgttaagctt cctttgcaat cattttttct   1462020
gcttcttgag ctaaaaagaa ttctaagatt ttcttagtca aactgatagt agctaccagc   1462080
acaattgaaa caagtaaata attagctact agaccgtgat ccccaaccaa tggcggtttt   1462140
gtcaaaaatc cgtaatcgcc acctgtcacc aaattgacca caaaaatcaa ggcatttagg   1462200
gcaaaggtca tgagaaaaat tcccttcaca tccagcaatc gcgcattata ctgtctcaat   1462260
agataaacta gagagttccc caagagtgct aaatgaccaa agataaagga tagaatggtg   1462320
atatgtggaa aagggtaagc atctggcact ggataaacaa aggctgctaa tgtcccaaat   1462380
gttcccaata atgcaaagta ttgtttatat ttggattgac caggaagcaa gagtaccaca   1462440
aacatagcca tacggcaatg gtaaaagggt aggctttctg acagtggcat atgattgacc   1462500
cagtaccaac cataaagaag gattaactga acagtctgca agatttggaa aaatcgttgg   1462560
taaaccttct tttcacgata gcgatgggct gtataaaagg ttaaggctaa gagcgtaaat   1462620
aggctaacat accaaaaaag gtcaaatttg ggcggctcgg ttgcctgagt cgtaaagaaa   1462680
atatcccata aattcatcta gtcttcctca taattcaaaa ttttcctgca tattattata   1462740
ccatgctagt tgttaaaaat ggatttagaa atacgataat catcttctta gtcaagatat   1462800
tgccccctat gaccttgata aacctgccaa agaagctcta tttgctcctt ggtaatgcgt   1462860
ttttcagata agttcggcag ttggtcaatg gcaaaaaatt gaaggtcagc aatttcttga   1462920
ttttcttgga attgtccatc aagaagctta catccaaaaa caaactttgt atactgtttg   1462980
ctctgtagtt ggaaacgatt ggtatcaaaa acagctagca gtctttcaac tttggcttta   1463040
aaaccggttt cttcttcaat ttccttgaga atattttctg ttggagaata gccgacttca   1463100
ccaaagccac ctggcaaagc ccaactatcc tctccttgtc ccctaaccag acaaatcttc   1463160
tcatcctcaa caatccaagc acggacgtcc attaacggag tcgcataagc agaagttggc   1463220
ttcaagactt ctgccacttc ttcggaatca aggtctgatg cttgattcaa catttcagat   1463280
aacagacttc gcaagtcttc gtagcgctca cggtcaaacg gatcttttgt aaaggttaag   1463340
ccagtatctg taatggcaat cattctttgc aaatacttga caaaatcact tgtcttcatt   1463400
ttctaaactt tctaccaact tggctagatt catagagtta gagcctttga gcaggatttg   1463460
gtcatgggct ccaaggcttt ccttgacctg cttgactagg tcttcaaatt gatcctggtc   1463520
ttctgttttc ttgaagtagt aaacgtggcc gattgggaac atttgactgg ccaattgggc   1463580
taattcagca atattttctc catagaaaat cacggtatca agcacatctg gagaaaggct   1463640
caaaatcatc tgattatgaa gttgaacaga ctggtcacca agctccttca tatccgccaa   1463700
cactgcaatt ttcttgccac cttcattggc tggaatggca gagaaagtct ctaaaatcag   1463760
tttcatagca gttggattgg cattgtaaac atctgacagg atatctgctc cattggctgc   1463820
tttcttccac tcggtacggt tacgcgtcaa ttcaagatct tggaaggcca aacgaatttg   1463880
ctcctctgaa actccttctt gcaaggcaac ataggatgca atcatagcat ttgtcgcatt   1463940
gtacttgcca gttactggca aatcaagggc ttgctctaag aaattggcct tgaaggtcag   1464000
actatctttg cgctcaacca agtcagtaat ttccagctct gccccttgcc caaaacgaac   1464060
caccttttta tcagttggca aatagtcctc tacgataggg tcagccggcg ctaaaagcaa   1464120
ggaacctgaa gccattccgt ctgcaatttg catttttccc ttagcaatct ctgaacggtc   1464180
tttgaaaaag gccaaatggg cttctccaac caaggtcacg atggctgttt ttggacgagc   1464240
caattcagac aagagatgaa tatcgcccaa gtgatcctgt cccatctcca aaaccaactt   1464300
ttctgttcct tcaggcatat gaagaactgt gtaaggaagg ccaatctcat tattgtaatt   1464360
gccttgtgtt ttgtaggtct tgtatcttgt tgacagtaaa tgcgccaaca tatccttagt   1464420
cgttgtcttg ccatttgaac ctgtaacagc aaagacatca acagtcgttt tttcaagata   1464480
gtaggatgct aaggattgaa aggctgtcaa aacatcatct actagaatgt aaggatgatt   1464540
tgagacctct ttctcagaca aggttactgc tgcaccattt tcaaaggctg tttcaataaa   1464600
gtcatggcca tcacgcgcac ctttaagtgg cacaaataaa tctccagttc caatcaaacg   1464660
actatcaaac tcagcttttt ctaactgggt gtcctcaaag atactgatat catttttggc   1464720
tccaacaact tgggcaattt catggattgt taatttcatt tctactcctt taaaaagggc   1464780
tgaagtccga gaactctagt caccgtgcag tgatggttct ggcttctacc ctctctttca   1464840
ttttatatca aatgcgcttc gcgcttgtca aaactttcct tggcaaggtc aaccaaacgc   1464900
tcgattagtt ttgggtagct gatccccata ttgtcccaaa gtagtgggta catagaccac   1464960
tgggtgaaac ctggcatagt attgagctcg ttgagaaaaa tctctccctt atctgtatag   1465020
aagaaatcgc aacgagatag accaaggcca ccaatggcac ggaaggctgt ttctgcattt   1465080
tgacgcatga cagccaccac atcatcactg attttggcag gaatatccat agtaatattg   1465140
ttatcaatat acttggcatc gtagtcataa aaggcaacgt ccttgacaac ttctcctggt   1465200
agcgtgctct tgacatcgta gttacccaag aggccaacct caatttcacg ggcattcact   1465260
ccttgctcaa ccaagacacg gctgtcatat cggaaggcaa gttttaaggc ttgacggagt   1465320
tcttcttggt tttcagactt agaaataccg acactagacc ccatgtttga cggcttagtg   1465380
aagactggat aagccaattt ttcttccact tcagcgattt tagcagtcac atcatcgcct   1465440
tcaacgatag ccacataagg aacttgggca ataccagcag attccagaac acgcttagtc   1465500
gtgattttat ccatggcaag acttgatgac aaaatgttgc aaccaacgta aggcattttc   1465560
aaaacttcca agaatccttg aacagagcca tcttctccca ttggcccgtg aaggactgga   1465620
aagaccactg caccttcttc gtagatagca cttggtgcaa ctttcttatc ccaatcaatg   1465680
gtttcattgg tcatgagacg gtcttcttgc cccggagcat gactaaattc ctgtgttttg   1465740
ataaagtcac ctgactgact gataaagaaa gtcttgactg tgaaacggtc gtaatcgacc   1465800
gcacgcatga cactctcagc tgaaaggaca gagacttcgc gttccgcact ccgtccacca   1465860
tataaaagaa taatcgtttg tttcatatta tttgtcctaa ttctactaga atactcgctc   1465920
tttagtatat catatttgct tggtttttta aaacttgaac ctgagcctac tcatcacact   1465980
atacaaaaag aggccgatag gaacgatttt cagcctcttt gattttttat aaatgaatgg   1466040
agttcgtaaa tttgcctaca cttacaactc tgtccgattt tcaatggctc gtaagagtgt   1466100
cacttcgtcc gcatactcaa tgtccgctcc cacagcgaga cctcgtgcta gacgcgtaac   1466160
cttgatacca gccggcttga gcaaacgtga aagatacatg gaagtcgctt caccatccgc   1466220
tgtagcatta gtcgccacaa tcacttctga aacctcacta tccataagac gagtcataag   1466280
gctcttgaga ttgatatcgt ccggactgat accattcata ggagaaatga ggccatgaag   1466340
gacatgatag agtccatggt attcttggat attttccatg gctgccacat ctctactatc   1466400
ctcaagaact aaaattgttg tctggtcacg agtcggatca gtacagatag aacaaggatc   1466460
gtcgtctgtc aaacgtccac aaatagaaca atatgtcaat tctctcttag cagaaaggag   1466520
attttttgca aattcattga catcatcagc agacatccca atcgtataaa aggccagacg   1466580
cgtagccgtc ttaatcccga tacctggtaa cttagaataa ctgtcaatca acttggcaat   1466640
aggtgttgga taaagcataa tttcctttct aattcattgg atggtatttt tgatacagat   1466700
tgataatgtc acgcgcaatg gaaggtccta caccatttgt tagattggta ttatgaggaa   1466760
agaccactgc gacagcgatt tggggattat cagatggggc ataggccacc gcattggtat   1466820
tggttgcttg ctgaccatct gccacatagc tttcggctgt acctgttttt ccgctaatgg   1466880
ataccaaggc accatttgaa aaggcacgtc cagttgtcaa tccactagta ccatgggcaa   1466940
cctgataaaa accttggtgc aagatgctca tatcggagtc ggatatattg accttattca   1467000
tctctgtcgg ttgcagttgc tgaatcaagt cacccagtcc tcccttatca ttattaccat   1467060
aaatgccttc aacaatacga ggagccacac gaacaccatt atttgcaata gttgctacat   1467120
actgagccaa ctgcatcggc gtatagttat caaactgccc aaaggcatta gtaatgtaat   1467180
tagcaaagct atactctttg ggaacaaatc cagtagattc atctggtagg tcaattcctg   1467240
tcgcagtacc caagccatat tcgccaaagg ttgaacgcag tttctccata gcagactcta   1467300
gattgctggt gccgacaaac atattgggtt gataggtttg ccccataaga cctaaggctg   1467360
tttggaccat ataggtattt gatgaatact ccagagcttg gaccgctgtg atagggaatg   1467420
aaccgtaagc ctgagtatac caagaattga tgggagctga accttggaag acaatggact   1467480
ggtctgtcaa ggtctggttt cctgacaaga ctccattttc ccaacctgag ctgatggtcg   1467540
ccgccttgac aaccgaacct ggaacaaaga cattggttac cgttcccaag gaatcaggcg   1467600
tcaactctcc cgttttcaag tcatgtttaa tccctgacat agacaaaacc gcacctgttt   1467660
ttgggttaag ggcgactgca tagacacctt cagaatactt ggctccacca ttttctagct   1467720
cagaattgaa ataacttttc agtaaagcat ccacgctatc ttggaaagcc aaatcaatgg   1467780
tcagtttgat attgtttccc ttactacctt cctcaattgt atccacgctt tccatattgc   1467840
catatttatc cagatggatt tcttttaccg agcgttttcc ttgtaaggtc tcttcatatt   1467900
gcttttccaa ataggaggtt cctacacggt catttagaga atagcctttt ttaagatagg   1467960
cttctgcttc ttccgctggg agaccagctt tttcactgga tacactccca actatagaag   1468020
aaagggaagt ttccaaaacc tttctatccc aagaagtaga aatactaatg ccaggcatct   1468080
cctttgaaat agaggcaata acagccacct gagaatcatt tagaggatct gtcgcaatgg   1468140
ttcctgtcgc aaagtttcca acagcattta actgactaaa aagatagatt tctttctttt   1468200
catcctctgt atagtttagt tgactcgttt gtacactatc gaccgcattg ttatacagtt   1468260
ctgattcgga tagacgattg ccatctgaat ccaagcgttt ctcacttggg agagcttcca   1468320
ctattttttt atagatttca ggatcagcca aatagtaatc cgccagctgg cgttctgtca   1468380
aatttggaga actgatgctc acataagtca gtaacttttt agctgtttct tttaagtctg   1468440
tagccgtcat tttattgcta cgcgtaaagg aaacaacctg ctttaacgta ttttctacca   1468500
aaggttttcc actagcatca taaatttccc cacgggctga actgcttgta atcttggtct   1468560
gactagctga agctagcttt ttttcgtaaa aatccttgtt caaaacctgc atatacaaca   1468620
aacgaccaat aatggtcata aagagtaaaa tgacgattga aaacaataaa ttaagccgaa   1468680
tcggaatcga atggctgtta aattttctca tacaaatcag tctcatttct aacttaaaat   1468740
cttactctta attgtaccac aatttgagta gaaaattatg gaaaagagag aagctttttc   1468800
gattttttcg tttttaaaac agagatgcgt ttttatttat ctatccttat attatgtgtt   1468860
ataatgaagt gtgactattc tctgatctag tcttccagta tgactcatgt aaaggagctt   1468920
tccctatgga caaaccagat atcgcaacta tcattgattc acattttgaa gaaatgacag   1468980
acctagaaca agaaatcgct cgctattttt tgcaagctga aacgattaca gatgatttat   1469040
cttctcaaca agtcacccaa aaattacata tttctcaagc tgctttgacc cgctttgcta   1469100
aaaagtgtgg ctttactggc taccgagaat ttattttcca ataccaacat caggcagaaa   1469160
atcaagccaa ccaagtctcc aagcacagtc cactgaccaa acgagtcctc agaagttata   1469220
gcaatatgag ggaacaaaca caagacttga ttgacgaaat ccaactagaa cgaattgccc   1469280
agctaatcga agatgctgag cgtatctact tctttggaac agggagttct ggcctcgtcg   1469340
cccgtgaaat gaaattacgt tttatgcgac taggtgtggt ctgcgaagct ttgacagacc   1469400
aagacggctt tgcctggaca accagcatca tggatgaaaa ttgtctagta ctgggcttct   1469460
cactttcagg ctcaactcct tctattttag atagtctatt agatgctaag gagatggggg   1469520
caaagactgt actctttaca agtgttccca ataaagatag ccagacctat acagagactg   1469580
ttcttgtagc cacccacagc caaccctcct atatccaacg aatatccgct caacttccta   1469640
tgctcttctt tatcgatttg atttatgcct actttttgga aatcaatcgc gaaagcaagg   1469700
aaaaaatctt taatagctac tgggaaaata aaaaactcaa cggctatcgt agacaaaaac   1469760
gtgtaagaaa atcctagttt ggctgagcca aactaggatt gttttgtctt aaaatgataa   1469820
tatgcaccca acatccctgc tgtattttgg tgatgggcaa attctaatcg tgttttttct   1469880
gctaaacttg gtaccaaagc ctctttcaag gctgtacgga tcttaggttt gaggatagcc   1469940
tcttgcccca tgataccacc accaagaata accacttctg gattggcaac gtagcaaata   1470000
tttgccagac cttttcctag atagtcaacc atacggtcaa taccttccat gcagattttg   1470060
tttccttcag tggcttcttt gaaaattcta cggccattcc actgatcaac atcttctcca   1470120
tgggcttcag ctacatattt cactaaagct gttgtagaag ccaagtcttg aaaagctcca   1470180
tcctgcatat gcatataccc gacttcacag gctgaattgc taaaaccatg gaagactttc   1470240
ctatccataa tcaagcaacc accgataccg gttccaatgg tcaagcaaag tgtcacactt   1470300
gctcccttgc ctgaaccaga tactgcctca gcaagacctg cacagttgac atcattttca   1470360
atctcacaag gaatagtaaa gctttcttcg atttcctttt tgaactgggt gcctgcgtag   1470420
ttagggattt gcggcccagc atagaaaatc tcacccttat ccggatccac catcccagca   1470480
gaagatatgg caacacctgc tactgggcct ttttctaaat aactagctac gatatctttg   1470540
gtcttttgta agatatgagg tccaccctta tgcgcctcag ttggcatttc atgcgattca   1470600
agaagttgcc cctcttgatc aaccaaacca tacttgatgt tggttccacc gatatcaatt   1470660
gcaacgtaat atgtcataaa tacctccttt tagattagag gaagcgctcc ttggtttcac   1470720
gaatcaaggc agcagccgct tctacaactg gacgatcttc ttcagtcact ggtgtcaatg   1470780
gtgaacgaac agatccaata ttcaagcctt cattgatttt caagacttct ttgatgacac   1470840
cgtacatatt tccatgagca gaagtgagtt taccaatgat tgcgttgata gcatactgca   1470900
attcacgcgc tgtttctagg tccttatccg caatcaactg attgagtttc aagaagagtt   1470960
ctggcatagc accataagta ccaccgatac cagccctagc ccccatgagg cgtcctccta   1471020
ggaactgctc atcaggacca ttaaagacga tatggtcttc tccaccaagg ctgacaaagg   1471080
tttggatatc ttgaactggc atagaagagt tcttcacacc gataacacga ggatttttca   1471140
acatttctgt gtaaaggctt ggagtcaaag caacccctgc caattgagga atgttgtaaa   1471200
tcacgtagtc tgtgtttgga gctgcagaac tgatatcgtt ccagtatttg gcaactgagt   1471260
attctggcaa gcggaaataa attggtggaa tcgttgcaat agcatctact cccaagcttt   1471320
cagcatggcg agcaagttcc atactatctt tagtattatt gcaagcaaca tgggcaataa   1471380
tggtcaattt acctttgcta ccgccatgac ttcttccaaa atcaacttgc gatcttcaac   1471440
gctttggtag atacattcac cagaagaacc attgacataa agaccttgaa cacctttatc   1471500
aatgaagtat tgaaccaagg cacgcgtacg ttctgggctt acttctcctt gatcatcata   1471560
acatgcgtag aaggctggaa tgacaccttc gtattttttc aaatctgaca tagattttct   1471620
cctattattt ttattttctg ctaaagcaga tttttcttta cttctttagt atacacttta   1471680
ccgaaaaggc tttcaatatc ttatagacac ttagatttta gtttctcgct tatagaatag   1471740
cgtttggagc ctttgaaagt agtttcagaa ataaagctcc tattggtatt ttgcgaaaat   1471800
tttctccatc aatccagtct ggataaagac caatagtcca aacccaaaaa gtaggaagac   1471860
tgagccacct aagagtagac tgaaggcgga cagataaaga accatcacaa tgaggacaag   1471920
aatggctaac atgaggaaga accaaggaaa gttaaaacta gccaacatca atcctttttg   1471980
aagaatttct ttccaagata ggtcataacg tgccgcgata gggtaactag ccagcatcac   1472040
gatagtaaga aaaatcagaa tacctaaaca aatggctttc agcaattgga agggcagagc   1472100
tgtttgaccc cagaaaagat agagatctga aagggtaaga aacacaattc ctaactccat   1472160
taaacccagc tgaagaccta gtttcagatt ttgcttgaaa gatcttagat agattttaaa   1472220
aacaggcacc cgtctgctct tcttaacttc gaacatggtc tcgtagaggc tgattttagc   1472280
cactccaatc gtcacgatgg gtaaacaaga gacgacaaaa agaagattgg ctgtcacgat   1472340
gtccaagacc ttctcactaa aacgcatgag aaagttatct gtatcaaatg ctgccttgat   1472400
aaggcttact cctttttgtg ccatgtttgc tcctccatca tttttctttg taaactgttt   1472460
tcttttttgt cagtaaagct ttcataagtc cctaccatga acaaatctat tttttctttt   1472520
ggactttttt ctatttttat ctatgggctt ataatcatat accccgaaca gcgaagcaat   1472580
taaaatagta ctccaagtat gcctatcaaa tccatctagc cctccacgaa ttatcattgc   1472640
aagcactgtc caagctaaca tattcaataa aaaaatacaa agtgctttca ttctcgcatt   1472700
ttaaaagttt atacgaccat tgttaggaat tttatcatat gcatcccaag ctgcagcaat   1472760
attgttggca aaattaccat atacatcagc tacattcaca gctactcgta aaatccatcc   1472820
agaaatcttg gtcagtaatc ctactcttgc tgctgcagtt gcagctaccc tacttaagat   1472880
cgagcgtgcc atactaatac catacttagc cgcataagta cctaatttta tgtatctacc   1472940
aatcaatgca ttcacaatgc ccctaattat ccaagccatc tcatcaactg taatcccctg   1473000
tccatctaag aaactagctc ttgcagcata cttagaagat accaattttt aaatatttta   1473060
ttctcatttc tctacctcac aaagatcaat ttcatggtag agtattatca aagctttaca   1473120
aaaaaacaat tcatcctatt tttaatcaat caaaatttta aagagatatt ttcgaacctt   1473180
ttcttccatg cctgcataac catttggctg atgtggctca cctgggaaga aaatcgcaaa   1473240
attgtgataa cccaacaaga gtgggtagtg ttcatgacaa tgaacaaagc caatgtcact   1473300
cgcttcgtcg aatgctactg cctcgtcttt gatacgtgaa ccgtagctcg aatattcatg   1473360
tccttctacc agcaaatgca aatctgcata gttcttatga tactcaaatt gatcattttc   1473420
agcttgattg aggacatttt cctgaacaac tagaaagact ttatctccat caatatcata   1473480
ctttcctaat tcgaaagaat ccttacgatg ttggtagaga tagtcgatag ccttgtctaa   1473540
attaggatga atccctttgt aaaaggtgat gtttttcaaa tcgtcaaaaa tcatactctt   1473600
tccttcgttt ctgatagtta actaaaacca ttcttaagtt tataagtgtc tgacaaaact   1473660
tcataaagta actgcatacc ctccattttg tagacactta taacctctat attctctaaa   1473720
tctataaaat atacttctgt atcttgatag attgattttc ctatactcaa tgaaaattga   1473780
agaacaaact aggaagctaa ccgcaggcaa tacttaagta tggcaaggtg aagctgacgt   1473840
agtttgaaga gattttcgca gagtattatc ctttgaccgc tcccatagta ataccctgtg   1473900
tgaaggattt ttggaagact aggaagactg tgacgattgg aacagcagca agggcagctc   1473960
ctgccataat caaaccatag ttggttgcca tttcagcctg catggtcgca accccaagtg   1474020
agatggtcaa attgttacgt gaagtcaaca ttaccaattg catgaagtag tcattccaag   1474080
tattgatgaa ggtaaagatt gcaagggctg caaaccctgg tttcacaatc gggaaggcta   1474140
cactccagaa ggtacgaatc tcaccacaac cgtcgatttt agctgattca agcaactctg   1474200
tagggatatt ttcactgaac tgtttcatga ggaagacacc gaatggccat ccaatcaaag   1474260
gcaagataac tgcccagaga gtatcatgga ttcccatgaa gttgacgata cgtaccaatg   1474320
gtacaaggac aacttgtttt ggaagcgcca tagcagcgat aaagatagca aatagaatgc   1474380
gttgaccata gaaacgtttt ttagccaata cataacctgc tagagatgag gttgcacaaa   1474440
ctaagaacat ggttaccaat gagataaata ctgagttcca catccattgc aaggcagggt   1474500
tctgcaccat gagttgttgg aagttttcca tggttggcat tttagggaac cactgaggag   1474560
gaataacaat tgtatcaggt tgtgatttga atgcccctgt caaaatccag tagaatggaa   1474620
agatgaacag cacagtcaac aagagcaaaa tgattgttga aataacagta aaggctgtta   1474680
atggtttttt ttctgtagat tgcatagctg tctcctttct ttagtattct acgtcgtttc   1474740
caagtacttt aaattgaaca aagcttacga tagcaatcat gactgccaag aagacaccaa   1474800
ttgtgttggc atagccgtat tctgtcaatt ggaaggcttt ttcgtaaagg tagtacatca   1474860
aggtacttgt tgagtagttt ggaccaccag atgtcaaaag ctgaatcaag gcgaaacact   1474920
ggaatgagtt aattgttgtg atgattgcaa tataaagagt tgttggaaga aggcttggcc   1474980
atttaatctt ccaaaaaact tgaaactcag ttgcaccatc aacacgcgcc gcttcaacca   1475040
gtgaattgtc aatattcccc atggcagcga tataaaggat gatgggctga ccaactgaag   1475100
tggtcaagag aataatcata atcgccatca atgcccagtt tttatctccc aaccaagaaa   1475160
tgttttggct gatgatgtgg ctggacttaa ggacaaagtt tagaatccct gatagtgggt   1475220
cataaatcca tttccaaaca actgtcacgg caacactacc cgttacaaca ggaaggaaga   1475280
agacgaaacg gtagaaggat ctggcaatga cattttgatg ataggtctga gatgctacaa   1475340
agagtgagaa tagaacaaca actggtacag atccaataac caaaataact gtgttaatca   1475400
gagattttgt aaagacagga tctttaaaca tacggatata gttatccaag cctacaaact   1475460
caaatttagt cattgagtag ttaaagaaac ttgtaatgaa gcccatcacc atcggagcca   1475520
acacaaagat gacaaagaag aataatactg gtgctaggaa agcgtaggaa atcactgttt   1475580
cccgcatacg gattttattg actttcacag tcggcacctc tctttcaaat agaataattt   1475640
tttgactttc ttgaactgtt ttaaaatcaa aatgaaattt tttatgattc gcttatgtaa   1475700
gaacttcatt ttaatttcgt gacagtttct tacattttaa acaaaagccc ccttttctta   1475760
cactatctgt gtagagggaa aagggggtat acactcttag gttctttaaa aaactacttt   1475820
ttatagaata actaaggact attgtttcat agcttttttg attgtttcgt tcgctttttc   1475880
agtgaaggct ttcaaagcat ctgctggttt ttcgtcacca tttgatacag attgcaacat   1475940
tgggaaccaa agtgttctca tttcagcaaa tccatcaata gtgttgtagt atggtgagta   1476000
gtattgagtc cagccgctga ttgtttccat gcgtttgtct tcataaagtt ttccaaatga   1476060
agtacggact gggaaagcac ctgtacgaac tacgtcttta ggtccccact ccttgtcatc   1476120
tgcgataaac tggatgaatt tcttagatgc agcgactttc ttgtcgtctt tattgttgaa   1476180
tactgcaaac ccgtttacaa ggtactcaag agctggctta ccttcgtctg atgggaatgg   1476240
tacttctacc acttctacct tacttgcttc taaaagttta gcttggatac cattttgagc   1476300
tggtgcccaa aggattgtgt aagatgtttg accgttggca aagttttgga tatctgcccc   1476360
accgtcaaat tgtgaaccat tattgatcaa attgtcttta atccagctag ttgctttttc   1476420
aagacctttg acgaatttag gatcatcagt tgtatatttg ctaacttttt catctgttac   1476480
agaaccgcta taaaggttag agataaaggc acgtgttcct tggtctcccc cttgaccaga   1476540
actgaacaat gaacctggtg tgtaaccctt gtctttaagt gctttcaata ctttttcaaa   1476600
atcatcagtt gtccaacctt cttttacaag gtttgctact ccagcatctt ctaacatttt   1476660
cttgttcatt gccatgtaga atggggcaga actaatcgga tacatataag ccttgtctcc   1476720
agctttactt gcttgtacga tgttttcatt gttgacatct ttaacaaatt catctgtgaa   1476780
gaggtcattc aactcagcca atttaccgtt tttaccgtat tggatgatac gtcctggtgc   1476840
atcaaagagt acgtctggag ctgttcctgc ttcgatggct gttgtgattt tttcaggacc   1476900
tgacttgaag tcgatggttt ccaatttcac ttttatatct gggtttgctt tttcaaacgc   1476960
ttcgatgatt gatttttcat aagttccaac accgtcacca gttttttctt gggtaaatac   1477020
tgggaatgcc caccaagtga tttctgtttt ggcaccgtca ccacctgatt tggcagcatc   1477080
tttacttccg ccagaattgc cacaagcagc aagaccaaga accgcagcac ccgcaagtac   1477140
tgtacaagct aattttctaa atttcatttg tattctccta tgtaataagc gtatccaact   1477200
tggataatga gttctttatt tcttgtatgc gatttcattt catcctactc atccatcact   1477260
ctcctctgtt ttttattaag tcagtaagta cttaatcatc tacacctaaa atttcattaa   1477320
tactattttt atataagatt gcttttgctc catagattgc ttgaatgcca cccttcactt   1477380
ctaagacatc aactgcacca atttgtttta aaagtgcttt atcaacttga ttaacttctt   1477440
ttacagctac acgtaaacgt gtcacacaag catctacatc ttctatatta tttgatccac   1477500
ccaaggctct gataatttgt aggctatcct gttttaaata atctgcagta tttgaagttg   1477560
aatctgcgga ttcagaaatt tctttagaat ctacttcttc tcctcgccct ggcgttagaa   1477620
cgttgaattg agtaatgaac catctaaaaa taatataata caaaacactc caaataagtc   1477680
caaatggaat ctgaagaacc caattcgtct tagcgttccc ctgcaaaatt ccaaataaag   1477740
tgaaatcgat tacacctcct gaaaatgtgt ttcctattga aatatttaag acgtctgcaa   1477800
taaagaagct aacaccatca aggaatgcgt gaacaacata tagaaccgga ctgacgaata   1477860
gaaacataaa ttcaattggt tctgtaatac cggtaataaa agatgttaaa gcaactccaa   1477920
aaaacaaacc cgcgtatttt ttacgacgat ttttaggaac actatggtac atcgctaaac   1477980
aggcagccgg taaaccgaac atcattgttg agaaacgacc tgcaaaaaac cttgttcctt   1478040
ctgtaaataa tccagaatgg gccaaatcgg ctaattgagc aaaaaatatt ttttgagctc   1478100
caaccactgt ttgtcctgca acagtttcaa caccaccaag ttcagtatac caaaacatag   1478160
ggtaaattat atgatgtaag cctactgctc cagaaagtct cattaaaaat ccatatagaa   1478220
aagttccaat tggacccgcc tgagaaatat atccacctgt agaaacaaga agttgttgga   1478280
aaggtggcca aataacaaag aagacaaagc caatcaagat agaagagaac gatgtaacaa   1478340
taggaacgaa gcgtgaacct ccaaagaatc ctaaagcgga aggtaattga atattgttat   1478400
atcggttgtg caaatatacg gcaactattc cgacaactaa tgctccaata actccagtat   1478460
caattgcaga tccttctgcc ataaaaagtt ttaccaaagc tttgatcgtt gcagtcataa   1478520
ctaagtaacc agttactcct gctaacgcag cggttccttt atctcgtttc gctaagccaa   1478580
tacataatcc cacacagaga agtagtgaca aattactgaa tacaacctct cctgcagagc   1478640
tcattacttg gaatattgat tgaaaaatac tattgtctag tattggataa gttgctatcg   1478700
tggttgggtt tgaaagtgca ccaccaatcc ccaaaagtag acctgctgca ggaagtatag   1478760
ctataggtaa cataaaagct tttccaactt tttgtaaaac tttaaacata aaactccccc   1478820
tcacatctta tttaagacta gcaacgaagc gttctgtaat ctcttttggt ctagtaatgg   1478880
cgccaccaac aacgatgcct cgcactccat attcaaggat ttgtttggct tgttctggtg   1478940
tatgaatttt tccttctgca atgacatcta caccagcatc acagagtttc ttaatcaatt   1479000
caaaatctgg accgtctact tttggactgt aggatgtgta gcctgataag gttgttccga   1479060
caaagtcaat tcctgcttct acagctgcta gcccttcttc gaagatacta gtatcagcca   1479120
tcaaaagctg attaggatat ttctccttaa cctgacgaat gaactcttga atttccaaac   1479180
catcgtagcg ttcacgcttg gtacaatcca gagcaatcac ctcgatgtcc agttctgcca   1479240
attcatcaac ttctttcata gtagccgtga tgaagggttc ctgaggtgga taatcacgtt   1479300
tgataatccc aatgattgga agtttagtga cttccttaat ttccttgata tcgcgaacac   1479360
tgtttgctcg gataccgact gctccacctt gctcagccgc tttgaccagc aagggaatca   1479420
cccctcccgc ttctgtataa agcggttcat gaggaagagc ctgacaagaa acgatgattc   1479480
catctttgat ttgctcaatc aaggcttctt tgctaatctg tggcatcctc tttcctcctt   1479540
ttctttattt ctatgagatt attatacctt aaaattaaaa cgctttcaat agtttgtagt   1479600
ataatagatt tcagtttcaa aaactagcaa agtcaaacag ctcctctaaa agtactttca   1479660
gaggagcaag tcgacctata aataggagaa taccaaaatt tattttacaa tttctgacaa   1479720
ttttactttg cgatcttcaa acatagactg ggtacaagca tctgcagtag caattgcttc   1479780
tagggcagct tcacctgtca aaagttttgc aaattcttct gatactggag ctccttccat   1479840
aatctcatgc agatagcgca tttctttatc aatgacagat gatagccata atggagtacg   1479900
tttacctggt ttaccataag caattgctcc atccatctct gtactatgat agatacgagt   1479960
ccgatcatca tcttcttctt gcgattcgtg aatcaagaaa tagctttctt gcccatctag   1480020
cttaagagtt cctttacagt tgaataagtc taagcggatg gcacctttgc ttccttggat   1480080
taagacataa tgttcacccc aacgataagc tgaaccccat tctaacaagg caaaacgctt   1480140
attagaaaat tccatattga caaaaatcat atcatcttca tcaccgaaat gttcaccttc   1480200
atgggccaca tttccacctg tcatggttac agtttcaggc atgcccccca taaggaattg   1480260
aacgcaatcc aattcatgga tgtggtgata caagtgacca cctgattttt cacgaatttt   1480320
tttccatgat actgacggtt gttgttcttc ccaaccatta cgagctgtat gacaatatag   1480380
aacgtctccg ataactcctt gattaatgag ttcttttgca tgatgaacac cattaaagaa   1480440
attcataata tgtcctgcca taaaggttac attgttttct ttacacgcat ctaccatctc   1480500
gcgacaatct tgataagaaa gcgcaattgg tttttcacag aaaacatttt taccatgctg   1480560
tgcagcctta ataaccggtt ccttatgaag attatttgga gttgcgacga taacacaatc   1480620
tacttcatcg ctagaaacca actcatctaa ggaacttgct acttttgctc ccaattcttc   1480680
tgcaatcgcc tctgcattat ctggatcata gagaagagta atctctgctc catcattctt   1480740
ttgcatgtag cgagccaatt cagctccaaa ataccctgtt ccaacaacac cgtatttaac   1480800
catgtttttc tcctttattt tgttaaatca ttaatttcca aatctatata ctgaactaca   1480860
ttgcttaaat gcaattcatt tctcgaccac gaatcatatt tttcaaacag tacacctatg   1480920
tgatgatttg gcaattctgt aatcgcagaa taggcataac catacgaagg caaatcaata   1480980
tcatagtggt atttccaatc aatactatca tcttctttat tgactaaacc gacaactaat   1481040
tggcctccct tgcggccact tctagaattt ggtgtactca aaatgactgc ttcttttcca   1481100
tcaattaatt gagagtattt aattgcagat acttgtgtgc catatgaagt ttgttggatt   1481160
ccatcaatat acgaaacttt cgaccatgtt tctccagaat ctctactagt catataagct   1481220
atcttacctg tagtggttct aaagaatgtt ctaatcacac catctctcag ttcaaccatt   1481280
tgtgcttctg ctgttgcatt tttaaacgga attgaagctg aggatttctt ccatgtttga   1481340
ccactatcat cagaaatgag ataggttagt tctccactag tatatgttgc aaaaatcaat   1481400
ctgttacttg attttaatgc taaaccttgt ccgggacata agtaagttcc attatgtttt   1481460
tctcctaaga acggaggcaa caacttaaat tgttcccaac tctctcctct attctgacta   1481520
gttgtcattg ctatataatt agtaggagtc actttaaata acgaatcttt gtagaaaaca   1481580
ttcataggaa cctgttttcc attatgcctt tctcttaaag agccactatc aaaatcaacc   1481640
gaatattgtt cgactgttaa agactttcct ccctccaaaa cttcatactt atcatttata   1481700
gtataatttg taggtttatt agttgtttca ttataaacga caccattttc tctaactgta   1481760
taacggaaat cgttatctcc attcttcttt agttttaaat aataatgacc atttatttct   1481820
ttaaaacctg agtcggcttt atttgcatta ttatttccaa tacccgcagg cataacatca   1481880
gctagtaata tcgttttccc agatttttta tcttcaacaa tggatgaatc tatgaatgaa   1481940
gcacttccac taatttgact attctttaat ttattatctc gtggccagta aactaactgc   1482000
tcctcatagt cattaaactt catagcaaaa attggctcac tccacgtttt cccattatca   1482060
tcactataag aagtggcaat attaatctta cttttagaat catgagtccc accataacgt   1482120
gcatcaatac ttgatagaac tcttccacta cttaatgtat atagtgtcgg tattctaaaa   1482180
tagttagctt gagtagaatc tcctgattgg aaaattaact gaaatggatt tgacaaggga   1482240
atagttgaaa cttcctgatc actaattgct ttgttaaata gactgatttc atcaatactt   1482300
ccttttgcga ggtaatgttc cttaccttca cgattaacag ctcctagtgt tgccttatct   1482360
ataccattta tatttgaaat tggcaaaaat gtatcaactg tttcagagaa cacttctatt   1482420
ccattaacat acattgtgta tgttttatct ttagaatcag atacaaatac tagtgtattt   1482480
tcaactgcct gtcctttatg ttttccccat aatgaagctg gtctggaaaa taaataattt   1482540
attccctttt gggcgtctct tatttctaca cctatctcac cagaatctct catgaaaatt   1482600
gaaaagtaat tatttttaaa gcctgcttta ctattagata ggccaaacaa agcttgaaga   1482660
gagtttggtt tatctgcttt aaatttcatt actactgtct gactctctcc agacaattta   1482720
tctaataaca aagagctgat atctatactc ttattgttca gttgatatga acctccttga   1482780
aaaataggag atatggacag ttgaccatag tttaattcat tcgcatgaat caaagtgggg   1482840
actcccatta aaagactaat gcctacaacg gaaattccta gttttgaata aagacctctt   1482900
ttattcattt ttttccttct ttcgtctact tcacagatcc ttctgataat ccacttgcaa   1482960
tcttattttg gatgatagag aagaaaataa ttgatggaag aactacaata acagacgctg   1483020
ccatcatatc tccccagtct agtatttctg aaccattaag tgaacgaagg gctactgcta   1483080
ctgtcatctt tcctgtattg ttaatcaaaa tcaaggcata caggaattca ttccaagcat   1483140
tgataaatgt ataaatagct gttgctacaa tacctggtgc tacaatcggt agcacaactt   1483200
tataaaacgt aacaaattta tttgcaccat caattctagc cgcttcttca attccaattg   1483260
gaactgtttg gaaaaatcca actaagagcc aaactgcata tggaacacta aaagatagat   1483320
aaaccatcat caagccaaat aaactatttg ttaacccaac tttagcaatg gcaattgaat   1483380
agggaattgc taacaaaatt ggtgggaaaa tgtaggtaat gacgagtagt ctcgacatga   1483440
ttgctcccaa tttaggaaag aatcgaacaa taccataggc tgccatagca gaaataataa   1483500
tcgcaataag ggttgtagcc aaggcaatga ttaaactgtt tcgaatgtta tcaatgaagt   1483560
gcaaatcgtt gataacatga gtgaaataat ctaatgtaaa ctgttcaggc caaaatcgtg   1483620
ttggatactg agttaattcc cctttccctt tgacagaaga tatgataatc cataccaatg   1483680
ggaaaactgc aacgatggtc gcaccaacta aaagtacatg tgagagaata tctaaataaa   1483740
tactggattt cttcttcatt attttctacc ctccttttcc cacttactga tgatagcaaa   1483800
gtagataaag caaatcgcca ccaagaagat aaagagcagt actgtaactg ctgaagcacg   1483860
acccaacaat ttagttcccc agcccaggtt gtaagcaaaa attggaagcg tcgttgtagc   1483920
attggctggt ccaccaccag taatgaggta gataatgtca aagttattaa agatccatac   1483980
agttctcaaa acaactagaa gtcctacaac cactttaata tgtggaaaga cgataaactt   1484040
gaacacctgc caacttgaag caccatctat cttagcagcc tcaaattgtt cttctggtac   1484100
tgtttgcaaa gctgaaagca cattaaccat aatcattggt gctccaaacc aaatgttgat   1484160
aaacaccaaa cataggaatg cccatgtact atctgtcaaa aatgcaggtg tatgttccat   1484220
taaacctaat tttacgatta gattaggtaa gtagccataa accccgttta gaatccactg   1484280
ccaagagaag gcaataacga tggtaggaaa tgcccaagga acaatcaata atgtcctata   1484340
taatttcttg aagtggcgta ctctgtgaag agctaaagcc aatacaaacc ctactaaaac   1484400
ttgaccaact aatgagaaaa cggtccactt aattgaatta aagaacgcat taaagaagtt   1484460
gggatctgat agcacagctt tatagttagc caaaccaaca aatttataat taggcataat   1484520
caaatgctta ttggtaaagc tataaaaaat actcgagaaa aacggataaa caaagagtaa   1484580
tcctacgata atcatagctg gcaaaacaaa tatccagcga gttaaattac gttctttaac   1484640
cattctcctt ctcccttctt ttacaagatt gggctagagc ttttcagctc actatcccac   1484700
ctattttcta gtcttttaca tctactgaac agcctcaaat aaatcattta attgtttttc   1484760
tgcttctttt gctgctttca taggatctgt tccatttgta atgatatctt ggaacatttg   1484820
ttcaataatg tgttggttag tcaacatacc agcttgtaca cttggcccat tttcataacc   1484880
aatagcagta ccttttttaa cagcttcagt aattacttct tcagcatgtt taaatttctt   1484940
acgagtttca ttttctttat aggctgcaga atcgctaatc cccttaatag ttggcaacat   1485000
acctactgga gttgaatcaa ggaatttaac gtagtcttct tcattataaa gtgcttctaa   1485060
gaatgcttta gcaacttctg gatgttttga atttttccaa acaaccattg gaatgtttga   1485120
ggtttcaatt ccttggtctt tatcagactc tttgattttt ggaataggat aagcatcaat   1485180
cgaatcaatc aattgaggac tgttggcatt aattcctccg atatggaagc cagagttaaa   1485240
gtcaaatgct gtttttcctt gatagaacaa ggtagcttgt tgaaggacat taaagttcaa   1485300
agaatcttga ggtgagattt ctttatacaa tttaacccag tatttaatac catcttgagc   1485360
aagttggctt gtcaagtctg ctttaagatc ttttgttaag aggcttcctc caccactacg   1485420
tacgtagaag ttcaagaaac gtgttgccat taagtcattt gttccaaacg gaacagacaa   1485480
gccataaact ccagcttctt tcaatttttt agaagcttca tagagttgat cccaagtttt   1485540
aggaacctca atattatgtt cttttaacaa atctgttcta acccacatga cttgtgcatg   1485600
tgaataaaga ggaacagagt agtaatcatc tccgattttt gcttcattta aggcagtttc   1485660
gttaaattta tcttgtccaa tacgcttgat agaatcattt agcggaacca aagcatctga   1485720
gttgaccatt tccattactt ggttaggaag agctgtactg atatctggca catttccatt   1485780
tgctaaacct gtagtccatt tagtatagaa gtcattccaa gaaaatgttt caatcttgat   1485840
tttcgttttt ggatgctttt gcatgaaagc atctgctgat ttttgaatac tttctaaacg   1485900
gggtccttga gtaaaggagt gccacattgt aatctcacca gataattctg ttggtggttc   1485960
agtactagtt gtagcttctt tttttcctga acaagctacc aaggcaacag ccgctagcgc   1486020
aattccagct agacataaaa actttctcat ttttttcatc gttcttctct ttctacatta   1486080
agaaatcgca actttaaaga caactttttt cacaggttca tcatttatac gaaccttggg   1486140
ttgatgtaaa tcttctggaa aagtgatgag gcattcgcca gctctcaaat gaaccaactg   1486200
ttccactttc cctgtgtata attcaatatc tttctcttca tcatattctt gggtaacgct   1486260
tacattttcc ggcgatgtaa cagccatggc ttcttcgttt tccaaaacta aatgaatatc   1486320
caaatatttt tggtgggttt caaagaaagc ccctgcttga ccatctgcta gataagtaaa   1486380
gcaattccca aacaatcgat taccatcgat agcaatcgaa ccttctgtta aattttctag   1486440
tcctgttttt tctagaaaat ctattaatgt tgcaaaatgt ggatttactc ccacataagt   1486500
tcctaaacgg ctaatttttg taataatcat ctcttctaac ctcctttctc aatctatttt   1486560
tcctatccaa gttccccatt cttctgtcta gcattttcta ctagaaggac ataaaaacac   1486620
tactctctag cctatactct ttgaaaatct cttcaaacca cagtcgcttc accttggatt   1486680
atataggtca gtcttatcta caacctcaaa gcggtgtttt gggcaatctg ctactagctt   1486740
gctagtttct tctttgattt tcattaagta tctcctcaat cttcacaagg aggtctgatt   1486800
tttctagcga caaacagaat aaataagtta gttcaattag ctaccttcct tatagatgaa   1486860
attgatattc atgaaggaag tcgcccttta ttttttgcaa aagatactag tatgaatcta   1486920
tttggggact tgaatttata agctgctcac ttcgtttttc taaaataatt ctaatctatt   1486980
attctagcac taatagactc tttggctaaa tctcctttct acatctcgtt tcaccaaaaa   1487040
cttttaagag agaaatactc tatatttcat tctctaaatt agttttgtta ccgttttcaa   1487100
ttagagtata cttttttttt tttagtattt caagtctttt tctaatttgg aatttagttt   1487160
caaatctttt ttaactatat caagtatatt aaaagtactt tcaaaaataa tcaaattctt   1487220
acaatacttg tttcgagtgg acaagataag aaaacaagaa agtcaatttt aggagaagac   1487280
aaggttaata gtcatataat atattgaatc tataacagta caccttgact gctaaaataa   1487340
ttctataaat taatttgact ttcctgatag agttgttcac atcttatttc aatctactat   1487400
attttataga acagactact ctgaaagtag tttcagacct cttatgattt cgtatcagcc   1487460
tgaatgtcat caaaaaaaga tagcaggctt gaaaacctgc tatctccttc tatttttacg   1487520
gttctataat atttgtagtg ggtaaatcca ctatagatat tatggagcct attttattgt   1487580
agaaaaaaag tcccatatga cctataatga aaagcgacaa aacaactcat tagaaagaat   1487640
catatggaac aattacattt tatcacaaaa ttactagaca ttaaagaccc taatatccag   1487700
attttagaca tcatcaataa ggatacacac aaggaaatca tcgccaaact ggactacgac   1487760
gccccatctt gccctgagtg cggaaaccaa ttgaagaaat atgactttca aaaaccttct   1487820
aaaattcctt atcttgaaac gactggtatg cctactagaa ttctccttag aaagcgtcga   1487880
ttcaagtgct atcactgttc aaaaatgatg gtcgctgaaa cttctatcgt caagaagaat   1487940
caccaaatcc ctcgtatcat caaccaaaaa attgctcaaa agttaattga aaagatttct   1488000
atgactgata ttgcccatca gctttccatc tcaacttcaa ctgttattcg taagctcaat   1488060
gactttcact ttaaacatga tttttcttgt cttcctgaga ttatgtcttg ggatgagtat   1488120
gcttttacaa agggaaagat gagcttcatt gcgcaagatt ttaacaatct caatatcatc   1488180
actgttcttg agggaagaac acaagctatc attcgaaatc actttcttaa atatgataga   1488240
gccgtccgat gtcgcgtcaa aattattact atggatatgt ttagtcctta ctatgactta   1488300
gctagacaac ttttcccatg tgctaaaatc gtgttggatc gctttcacat tgtacaacat   1488360
cttagccgtg ctatgagtcg tgtgcgtgtt caaatcatga atcaattgga tcgaaagtct   1488420
catgaataca aggctatcaa gcgctactgg aagctcatac aacaggatag tcgtaaactc   1488480
agcgataaac atttttatcg ccctactttt cgtatgcatt taaccaataa agagatttta   1488540
aacaagcttt tgagctattc acaagacttg aaacatcact atcagctcta tcaactcttg   1488600
ctgtttcact ttcagaataa ggaaccggag aaatttttcg gactcattga ggacaatcta   1488660
aagcaggttc atcctctttt tcagactgtc tttaaaacct ttctaaagga caaagagaaa   1488720
atcgtcaacg cccttcaact acactattct aacgccaaat tggaagcgac caataatctc   1488780
atcaaactta tcaagcgcaa tgcctttggt tttcggaact ttgaaaactt caaaaaacgg   1488840
atttttatcg ctctgaatat caaaaaagaa aggacaaaat ttgtcctttc tcgagcttag   1488900
ctgacttcaa cccactacag ttgacaaaga gccattttta caaaatcaaa tgtttagaat   1488960
tcttctctta ttgttctctc tttttcccta gcgtaaacag accaaggaag aaagctgtta   1489020
gtcctagtga agctaggagg tcactctcct tgtttcctgt ttcaggaagt gcctgctgag   1489080
caagaggagc tttgtaagta taatcttttt ttgtagtaag agttacaagc gaatcagatc   1489140
ccttatactc tgcgatttca tgaacagctg gctctgtacc attaactccc cctgtaaatt   1489200
ctggaacttc atgcaccgct gctttgctac catttactcc gccaggaact ctggcacctg   1489260
ctagatttac aggaagatta tgcatacttt cgatgcttcc tttagctata ccaataattt   1489320
cctgtccgat atcttcctta tctactgcaa acaacaaggt cttgctatca tactgggtta   1489380
ggaaagtcgc tgttttacca tttgccaatt gaagggttgg agccttgttg accaatactt   1489440
ctgagtcgaa ctccaagcca ataactcctt tgcccatctc tcctttgccc atctctctag   1489500
ttcgcttcgg taggagaaat cagatttttg ctcaaaaatt cccaattaaa ttttctaaat   1489560
gatagggtat aggcattttg tcctttttca gtatgttcat acaagatgcc atactcccca   1489620
tttcctaatt cttggagcga attataggca aactctcctt tttgaattgg attgtgtttg   1489680
agccaagtca actcaccatt ttcttcgaca cgtgccaagt ggaccatccc attttcacgt   1489740
ttcggtccac ctgcattact gaggatgatg tattcttttc cttcgtgcat cgtatggata   1489800
gcagacattt gaacatagac atctttaacc tgtggataac gtttgatatc cttctcccaa   1489860
gtcactcctc cgtctttact tgtagcaacc tgaagatctc cagtcaaacc acgcataaag   1489920
agtttaacat ctccattgtt tagttgtacc accgttgatt ctgtattttg cgcacgtcta   1489980
ttgttcatcg tagaagagtg gatcttttga ccgtctacct gacggttatc gttgaccgct   1490040
tctccagcat gccaagtttt tccatgatca tctgaataga tgacacgaga agattgcgag   1490100
ccatctaagt gagatacatt attagtcgta taaaccggta tcaaaatccg tcccttgtga   1490160
ggcccattcc gaagtacaat tcctgttcca ggacctacac ccaagaattt catccaatcg   1490220
gctttgacca tcggagtaat atcttgagga gctgaccatg tcttcccgtc gtcatcactg   1490280
taggacatcc atagatagct atccttggca attctaaatg gagaagtttt gtttgttgtg   1490340
aagtagatat ttcctagtaa ttggtcaccc ttgtatagat cacccttgtc gctataggct   1490400
ggtttaacag gatctacaac aacgcgatag tctgtcgcct taccatctgg tgtatagaca   1490460
gtaccatttt ctcgaatggt ataagctccc ttttctcctt cacggtagag gatttgatag   1490520
gtttttccat cgattttttt gtaggcttct tctttttgtg aagacattcc aaagattccc   1490580
ttcccttctg ggaacatgtc atagatagaa aagattcgtt tggtttcagg atcttgaacc   1490640
aacaccatat cgatattcac tggtgaaccg atcgatgggt cagaagcttt tggattgtca   1490700
cgtaagttgg taatggttac tcggtcaccc caagttttac cattatcttc actacgtctg   1490760
atgaccatac cgatatcacc ccagtcactc gaatggagac ggcgttcatc tgcacctgcg   1490820
atcaaagttc ctttatctgt cttgagaagt gctggaatac gataactctt gattccatct   1490880
ttatttgggt taccgttacg cccgctttcg aatatgtccg ttttctctgt taaagccgct   1490940
ccttcaggta gttttttttc taaatctgag cgtttaaaaa gttgactacg tttttgtacc   1491000
tcttctggtg ttaaagcacg attatacaca gtgagattcc gaatctgtag atttgacccc   1491060
caaaccgtat tgttggcacg cttggttgct ccgatttgca catgcgttac atctggcata   1491120
tctttaatga aattgccaga tctcagactt gttcgagata ataccccgtt tacgtagagg   1491180
cgcactcggc ctttaggtag ttctgctgtc ggtttttcaa ctgtgaaagt cacagaattc   1491240
cactgacctg gtttaacttt taagggtgca tcgttgtaat tattgtaaaa ctgtttccca   1491300
tccgaaccac gcccctctag agtagcagta ttattgtaaa ctgccatagt gaagtactca   1491360
tcttttttag tagcacttga cacagaaaag agattataga atgctggggc cttggcatct   1491420
ggcttaaact ccatgtgaac tgttgcgttt tcaagtttct ttagtttatc tagttcactt   1491480
gataaatcaa ctctctgacc atttgaagca ttggtttcaa catcttcttt ttctatcact   1491540
gtttcgacat tttccaaatc tcgtgcatag taatctcttg gaattttttc ttcttgctta   1491600
tctttccttt cttgttcttg cttattgcca gaaagttcag tctctgaaga aggctggctc   1491660
ttttctgtat cagttagggt tgagctctcc cccgaaagtt gagtttcatt tgccagaggt   1491720
tgctcacttg ccccttcttg agctaaaaca ggagacgttc caaataccac tgctcctaca   1491780
atcatagaaa ccgctcctac cgatagtttc ctaatgctat aacgacactt acgttcttga   1491840
acactccgat tcatactgat cctctctata tctatatccc gatttctgaa ataagacatt   1491900
tactccagaa aatgcactta gtttgtcttt tattaacttt cttttactac agttcattta   1491960
aatgacaaaa atgaactaaa caaactatct caaattggtg ccaattttcc cctctccttt   1492020
ctccaatcag actcctgcca atctagttta tctaccagga caccgctgca attaaactaa   1492080
aatatctctt tataagcaaa tgatggacat cagcctatgc tatttacacc atacttcctg   1492140
ctcaatcctt atcgaacact ttttcaaata gcttttcata agcataaata cttgtagaaa   1492200
taatgggaaa tataatcaag ctcacaatca gaatcttatc cagcttaaag gggacaatcc   1492260
caaataagtg aagaaataaa tcaatcagaa aactgtcgaa aaaaactgtc aaaagtagtt   1492320
caacttgtct ttttctctgc ttttttgtct tgaatgcctt aaatatcata ttattcccct   1492380
tttctaagct tcaatccctt ctctctatct gttatttcgc atagctacta ctatttttac   1492440
agcaatctat ctttaaatat acataaaaat agattctatc actttttata agcgttagta   1492500
aatttattat acctcatttt taaaacgctt tcaatatagt gtaatatagt agattttagt   1492560
ttcaaaaaat tcttttatat aataatgtcc ttgaaagtag tttcagctga acatttatag   1492620
tccataaaaa gaaaacagaa actcatctgt ttttatactc aatgaaaatc aaagagcaaa   1492680
ctaagaagct agccgcatga tgctcaaaac actgttttga ggttgtggat agaactgacg   1492740
aagtcagtaa ccatacctac ggcaaggcga agctgacgtg gtttgaagag atttttgaaa   1492800
agtattaaca cctacagaca agcctgacga tagcaagaac taccctactc gataggtatc   1492860
ggcttttgct ttctgaaaaa aattatttta agcaatttga caaatctagc aacaaaaaat   1492920
tctataaata taatagattg acactagaat agtacacatt tgtttctaaa acattgttag   1492980
aaatcgattt gactgtcctg atcgatttgt cctgttctta tttcatttta ctatatttcc   1493040
atgataaaac gcatagtata aagttttctt aatcccctga tactatgcgt gtttgtaatt   1493100
tttaagattt tgtgcttaga gtcgactcct tattttagat atttaaaagg aatctcactt   1493160
ccacagagcc agttgtagac ttggtcattg acaaatacat tcatggcttc gtgagcatac   1493220
tcaggcatga tgcgataggt tttatcgcag gtcagacgat tataaatcgc aaactgggta   1493280
atgggatagc aaacatcgtc gtccaagccc gtaatcatct taacctcacc ttggatacga   1493340
tgggcaagat ttttgacatc gatataggca agggtcgcca tgatttcctc ctctgtttca   1493400
tggaaggggt cgtgaaactt gaaataacgg aaaagttcgt cgtaagcctc gctagtatta   1493460
ccaatctcaa tcacccgtct gaagtctgac aagaagggat aaatggcaac tgttttctga   1493520
attcgaggat tgagcgctgc tgcaactaga gctagagccc ctccttgtga ggcaccatag   1493580
ctagaaagac gcttctcatc aacctgagac agactagcaa caatttcgac caactggtaa   1493640
atatccagat aaacatcctt ataaaagagg tggtcccgac cttccacagc accacggata   1493700
atatgcccct tcacggtatt tcctaaagga gaacgcaagc cgtcttgtga gtaacctgac   1493760
tggccccgca catccatgga aacaacaccg taaccagcta cggtgaagcc cagcatgtcg   1493820
gcccagtccc agccacgtcc catataacca tgaaaatgga agattaatgg gaccttctcc   1493880
tcactctttg gaagaacaat gcgtgcatag acctttcctt ccttgcttcc ttcaaatgtt   1493940
aactcatagc acttgacttg aggaatgtgg aaatctcttt cctccaagtg gtaggatgga   1494000
agcgtggaaa catttttcac ttccccatcc cagaaatcat caaagtcttc cggaacctca   1494060
tcccttcctc tataggtctt aatttcttct agcaaagctg gatttttcat agcatgctcc   1494120
ttttattttg taatcgttac cacaactgta gcatatctat gtaatcaatg caagaaagaa   1494180
gggtaaatag aaagtgaatt tagattcttt acttttagga tgatgggctg aaagtagttt   1494240
tagaaacgaa aaaagagcat ttcgctctct cttctgttta tactagtttt ttgcttcctt   1494300
cttttggaaa gtggtttggt aatttacttt aatcgttact gtcatatgag agtcctcgtt   1494360
tctttttgat gactctagta taagagccaa acctaaaaac tagcttaata ctcttcgaaa   1494420
atctcttcaa accacgtcag cgtcgcctta ccgtatatat atgttactga cttcgtcagt   1494480
tctatctgcc acctcaaaac ggtgttttga gctgacttcg tcagtttcat ccacaacctc   1494540
aaaacagtgt tttgagcaac ctgcggttag cttcctagtt tgctctttga ttttcattga   1494600
gtataagttt tccttagaga aagcttaatc cagatgttct ttcttttcca gatgaagggc   1494660
aatcatgcgc cactctggat cttcttgcca agcttctata gaactaatgt agctagcaac   1494720
ctttcttgct tcttctaaaa tcggaaaatc ttcgataata tcagccactt ggaactctgg   1494780
aagtcctgac tgtctggttc caaaaatctc accagaacca cgcattttca aatcttcctc   1494840
cgcaaggaca aatccattgg tcgtttctgt catgatacgc atgcggtctt tcccagaatc   1494900
cgtcttggga ttagcaacga gaacagcgta ggactgcttg tccccccgac cgacacgacc   1494960
tctaagctgg tgaagttgac tgagaccgaa gcgatcggca tccatgataa tcatgacagt   1495020
cgcattggga acgttgaccc caacctcaat aaccgtcgtc gaaaccagaa tatccgtctt   1495080
tctctccttg aaatcctgca tgatctggtc tttttcgtca ctcttcatcc taccatgtag   1495140
aagagccacc tctgccttgc ctgcaaaatg agtcgtcaac tcctctgata aggcaatggc   1495200
atttttcaaa tctagagctt ctgattcttc aatcaaagga gagatgacat agacttggga   1495260
acctttttga atttccccct ctaaccaagt caagacctga ggtagttgct catgtttgat   1495320
ccagcgcgtc acaataggct tccgacctgc tggcatctgg tcgataatgg aaacatccat   1495380
atctccaaag gctgtgatgg caagcgtccg tggaatggga gtcgccgtca tcatgaggac   1495440
atctggattg tcaccttttt cccgtaaaat acgcctttgc cctacaccaa aacggtgctg   1495500
ctcatcgata ataatcaaac caagacgagc atactccacc ccatcttgta tcagagcgtg   1495560
agttcctata atcaaatcag cctcaccctt ggcaatggtc tccaagactt ctctcttttc   1495620
tgcagctttc aaggaacctg tcaagagagc cagtttcaaa ttgggaaaaa ggttctgtaa   1495680
actctcaaag tgttgctctg cgaggatttc tgttggtacc attagggcag cctgataacc   1495740
tgctgtcact gccgcaaaca tggccaagcc agcgactacc gtttttccac tccccacatc   1495800
cccttgtagg agacgattca tgtggtggtc ggacttcata tcagttaaaa tttcctgcaa   1495860
actcttttcc tgagcttggg tcagggcaaa aggaagactt actttaactg ctgtcacttt   1495920
ttcctgagac caattcagaa ccagaccact tccctgaact ctattttcag acttgagcat   1495980
ctgcagctgc atttggaaat aaaagagttc ctcaaacttt atacggcgaa gagcctgctt   1496040
gtattctgcc aaatactttg gaaaatgcat agcacggact gcctgacaac gggacatgag   1496100
tttgtatttg tctagtaaag actggggcag attttcttct atcaagaggt ccagtccctg   1496160
atcaaaagcc gtcttgatga ccttgaccag actggcctga ctgattccct gagccagacg   1496220
atagacaggc tggaggtcat cttctacctg agccagaacc ttcatcccag tcagactagc   1496280
cttagcgcgg tcccattttc caaagacagc aagggttgct cccaactcta ttttatcagc   1496340
cagatagggc tggttaaaga aattcaccgc aaaaacgacc tctccctgct tgagactaaa   1496400
acgcaggcga ttgcgcttga aaccataata ctggacacta gcaggagtca ctacctgacc   1496460
agaaagaact gccttctcac cgtcttccag ctccagcacc tgcttggttt tgaagtcttc   1496520
ataacggaaa ggaaagtaga gcaagagatc ttgcaagttt tcaattccta gtttggcgta   1496580
tttttctgct gactttggtc ccacaccagg caagacatgc aagggttgat gtagattcat   1496640
gctccactcc tttcttttct aataatattc tctcggaata cggtcgctga ggaggcaaac   1496700
cacctcatag ttaatggtta cgcggtaggt cgctacctga gttgcagtga tttccttatc   1496760
cccattggag ccaatcaagg ttaccttggt tcctagcgga taaagcttag gcaatcgaat   1496820
agtgatttgg tccatcgaaa ccctgccgac aattgggcaa gcttggccat ctaccaagac   1496880
agagaaattt tgcatgtctc ttgtccatcc atctgcatac ccgattggca cggtcgcgat   1496940
gacttgctcg ctatccgctt gataagttgc tccatagccc atgcaagctc cagctggaac   1497000
tgtcttgaca tgaaccagag cagactccaa ggtcaaggcc ggtatcaaat cataaggcaa   1497060
atccaagacc gctccacttg gattgaggcc atacatggca tctcccatac gaaccgcatt   1497120
gaaaatagtc tctacatgcc aaagagtcgt tgcagaattg ctagcatgaa ccagctctgg   1497180
aacttccttc atactagcta aaatagtttt aaaccgttct aactgggcat taaaatagtc   1497240
atctgattcc tcatcagcag tagcaaagtg ggtaaagatt ccttcaacac aaacaccgtg   1497300
ttgttggagc aaatcttgag cctgctcaac ctcacttgcc tctctaaaac caatccgtcc   1497360
catccctgaa tcaatcttga ggtggactgt caatccagtt aggtccactt ccttatctaa   1497420
gagtgcttga atccactcca gtccagccac tgtcaaggtg aagtcatatt ctttagctag   1497480
agcaacagct tcgatttcag aaactcctaa aatgaggatt ggcttgctga gtccagcttg   1497540
tctgagttca atggcttcat cgatattgga aacgcaaaag ccatcaacat catcttgaat   1497600
tgccttggca acggcaacag ctccatgacc ataagcattg gccttaacca cagccaactt   1497660
gagcgttcct tgagggatat gagcccccat ttgctgaata ttttgtcgaa tagctcccag   1497720
atgaatcaga gccttggttg gtctatgtgg actagctttc atgattttcc tccaaaatga   1497780
cactggctgt cacaaactga tcggtgtggc tgatagacag ccaaatcttt cctgaaaatg   1497840
gtgcctgact aaaataaggc gccccacgtt cattgttcaa gacttccaaa tcctgaaaac   1497900
cgagcttgct aatgcccgtt cccatagcct tggaaaaggc ctccttagcc gaccagcgac   1497960
cagctaaata ttctatttgc ctgcgtcctt tgagactggt gaagcgctcc atttcctgag   1498020
cggtcagtac acgcttagca aatccttcat gtcgtgtaac tgcgctttct atcgaagcca   1498080
attcttcgat gtcaattccg tgtccaacta tcattctcat caaaaggagt tgagattccc   1498140
caactccatc cttttcactt attttgtcaa ggtaacataa atctcttcta ccaaggcctc   1498200
tgtattttcc caacctaggc aagggtcagt aatagagcaa ccaaagatct ctggttggtt   1498260
ttgacgacca tctgctaggt aagattcaat cataaatcct cgaaccgtct ttttaatttt   1498320
ctcattccaa tcacgattct gcaaggtctg gcgaacaatt cgaatctgct ccatatattg   1498380
cttgcctgag ttatcatggt tggtgtcaat gaggataaaa ggattttcaa gtcccatggt   1498440
ttcatagcgt tcaatggctt ggagtagatt ttcatagtag taattcggca tataattgcc   1498500
atactcgttg actgctccac ggaggataac atgggccaaa ggattacctg atgtctcaac   1498560
ttcctgccca tgataaagga aggtttgctt gttttgagca gcatagatgg cgttaaacat   1498620
aacacccaaa tttcctgagg ttggattttt catccctact ggtgcatcaa tcccagaagc   1498680
cacaaagcgg tgctcttggt cttccacaga acgagctcca acggcatggt agctgaccaa   1498740
gtcatccacc aagatcagat ttgacggata aagcatctca tctgccgttg tcaaaccagt   1498800
ctctgtaatc acgcggtagt gcaactggcg cacagcctgc aagccattaa tcaggcttgg   1498860
agccttagaa gtatctggct ggtgaactaa tcctttatag ccgtctccat tggtacgagg   1498920
cttagcagta tacacgcgca tgaccatgaa aatcttatcc gctaccttct tttgcaaggc   1498980
agataaacgg cgagcatatt ccaagaccgc ctcttcatta tcagaagagc aaggaccaat   1499040
caccaagaga atacggtcat cttcccctga aataatatct gccaattccc tgtcacggct   1499100
ttccttgagt ctcaaggctt ccgcagacaa ttgggtttca gccttgatga cttccatatc   1499160
gatttcttga cctttttcaa taaatgccat cttattctcc taacgttttg taaatttctc   1499220
tgacaagagc ttctgtgtta tcccaaccca ggcaagggtc tgtgatagac ttaccaaata   1499280
cttctggctc attttgtcga ccatcttcca gataagactc aatcataaaa ccacgaacga   1499340
actgcttaat tttttcattc caagcacggt taatcaaggt ctggcggaca attcggatct   1499400
gttcaatata ctgcttacca gaattgtcat gattggtatc aatgatgata aaaggatttt   1499460
ccaagcccat tttctcatac tgggcaatgg tatcaattaa attgtcataa tagtagttgg   1499520
gaatattttt tccatactca ttaagagcac cacgaagaat agcgtgtgaa agcgggttcc   1499580
cagttgtttc tacttctttt cctaagaaaa ggaaactttg tttgttttga gcagcataaa   1499640
tcccattaaa catgacattg agatttccag aggttggatt tttaaaacca gtagaaaatc   1499700
ctgccccact tgccacaaag cggtgttgct ggtcttcaac tgaacgggca ccaactgcca   1499760
tgtaagaaat caaatcatct acaagcggaa ggttttcagg ataaagcatt tcatcagcag   1499820
ttgtcatccc tgtttctgtg atgacacgat agtgaagatg gcgaacggct ttgattccat   1499880
tgataagact aggcgcttct gtcgcgttag gctggtgaat caagccctta tagccatctc   1499940
cgttggtacg gggtttggca gtataaacac gcataaccat aaagatacga tctgccactt   1500000
cttcttgtag gactgccaaa cgcttagcgt attcaaggac agcttcttcg ttgtcagatg   1500060
agcatggccc gattaccaag agaattcgct ggtcttctcc acgtataatg gcttctagct   1500120
cttgatctcg ctgtgatttc ctctccaaag cctgaccttc taattttgac aaggcacgaa   1500180
cttcttctat atttatttta gagctttttg ctgtaaatac cataactcat ctccttataa   1500240
agcaaacgga tacccagtaa aaatttactt ttcacaagat atccgcctct aaactatctc   1500300
attttattgt cttttaccgt gacagttttt aaatttctta ccagaaccac atgggcaaag   1500360
ttcattgcgt ccaatctggc tcaaatccaa atcttctggc atacttgctt ggtgagcagc   1500420
gatattgcga gtcgctgttg tactgatatg acgttctgcc tgtggtcttt cttgttcatg   1500480
aatttgtgct ttcatcatca agcgtgtcac atcaaactca atcgaaccaa tcatatcatt   1500540
aaacatacgg aaaccttctg cctgatactc aacaacaggg ttgttctgag catagccacg   1500600
aagtccaacc gcgttacgca attgatcaag ggcatcgata tgatctgtcc acttgttatc   1500660
caccactcgt agaatcaaaa ctttttggaa ttctttaact gcttcttcat cgcgtagttt   1500720
tgaaacctga ctatcgtaaa ccttcaagga acgttggaaa agctcttcct tgatggcctt   1500780
atcagacaag cctgacaagt cttccatcgt aatagaatct tcaggaagca agttgtactt   1500840
agcaaagttc aaaattgcct ctagtttttc atcttgtttg gcacgcgcat gaccatcaac   1500900
gacacgttca atcgtgcgtt tgatcataga ctgaatttca ggtgccaagt cacgatctgc   1500960
agtgatgaca tcgtaacgtt gagcatagat aatctcacgt tgttcacgca tgacatcatc   1501020
gtattgaagg acttgtttac gggtatcgta gttatttcct tcgacacgtt tctgagctgc   1501080
ttcaacctga cgcgtcaaca tgcgagactc aatggcctct tcagacatgt tcaagcgttc   1501140
aaagattccc ttcaagcgtt cagaaccaaa acgtttcatc aaatcatctt caagagatag   1501200
gtagaattgt gactcacctg gatctccttg acgacctgaa cgtccacgaa gctggttatc   1501260
gatacgacga ctttcatgac gttctgtacc aataacacaa agtcctccaa gttcacgaac   1501320
accttcacca agcttgatgt cggtaccacg acccgccatg ttggttgcga tggtaacggc   1501380
accacgttga ccagcattca tgatgatttg ggcttctcta tagtggtttt tggcattcaa   1501440
gacttcgtga ggaacaccag ctgcaaccaa tttcttagaa atgtagtcac tagtttcaac   1501500
cgctactgta ccaaccaaga caggttgacc cttttggtaa cgagccttaa cgtcttcgac   1501560
aaccgcttta aacttagatt cgatacttgc ataaagaagg tctgagtggt caatacgttg   1501620
aacaggacgg tttgttggga ttggaataac acgaatgttg tagatttcac ggaattcttc   1501680
ttcctcagtc ttacctgtac ccgtcatacc agacaatttc ttgtacatac ggaagaggtt   1501740
ttggtacgtg attgaggcag atgtcttggt ttcatcctgg attggcacac cttctttggc   1501800
ttcaatagct tggtgcaatc catcagaata acgacgacct tccatggtac gacctgtaaa   1501860
ttggtcgaca atcaagattt cttgctcttc gctcaccaca tagtcaatat cgagaagcat   1501920
gatgtagttg gcacgaaggg cgttatcgat aaagtgagtc aaagccacgt tttcgatgtc   1501980
atagaggttt tcaagtttga agtagctttc agccctgtca atccctgaat cagacaaacc   1502040
aatagtctta gactgcacat cgatgatgta gtcatctttg ttcaaagatt ttacatagtg   1502100
gtctgccatg tgatacaact gactggtttc aaccgcattg gcacctgata caatcaaagg   1502160
tgtacgagcc tcgtcaatca agatagagtc aacctcatcg accaaggcat agttaagcgg   1502220
acgttgtacc atgttttcgg cgcgaacgac catgttgtca cgaaggtagt caaatccgat   1502280
ttctgagtta gttgagtaag taatatcaca ctcataggct tcttttttct ccattggaga   1502340
tttggtagcc aagttaatcc ctactgacaa accaagccaa gagtacaatt cacccatctc   1502400
agtcgcgtca cgttctgaca ggtattcatt aaccgtaact acgtgaaccc ctttacctga   1502460
aagggcattg aggtataccg gcatggtcgc agtcaaggtt ttcccttccc ctgtacgcat   1502520
ctctggcacg tcaccatggt gaagaacaat cccccccatg acctgaacct tataagggaa   1502580
gagacctagg acacgtttgg caccttcacg gacaaccgca aatgcttcgt aaagcaatga   1502640
atccagtgat tctccatttt gataacgttc cttaaattca actgtttttg cttttagttg   1502700
gtcgtcagtc aaagcagcca tttggtcttc gtatttgaaa accttgtcag ccatcttttc   1502760
cagacgacgg atttctcctt tatcattttc gataattgtt tttaaaatat tagccatgtt   1502820
tttccttact ttaaattccg aatattttag aatgttcctt taattttagc acaattactg   1502880
attattttca aggaagaatc cccattttga aaaggaaaaa gaggttagtt ttcaagctaa   1502940
cctctccgac ttttatgact gtttaattgc caaaaatcgg caaaatggca aatgtgataa   1503000
ataagttaat ccaaagagaa agacagcaaa tcagtccaaa aacaaagaga ctgactttct   1503060
tggacagcaa ggccatgaga atggacagaa ttccaaaagc tagcaagatt ttctgtatga   1503120
tgaagatgtc aatccttatc cccagaagtg gtttatccca agggataaag aagaaagaca   1503180
gccagatcag cagaactaaa ccaatataaa ccttggaata tcgtgtaata aatgatttta   1503240
gatgtgccat aagccatctc ctaggattgt atatccttta catttgtata tgtccatttt   1503300
cgacaactaa tacatctgta caaaggtctg aaatatcttc cgatatgtgc gacgtcagga   1503360
taaccagacc attttctttt ttcaggtaag ataaaatgac ctgtttggtt aacctcacac   1503420
tcttctcatc caaagcattc ataggttcat cgagaaagag tatagaagga gaggaaataa   1503480
aggcttgaat caaggccatt ttttgctttg ttcctaagga taaatgacgg tattcaatgt   1503540
cttcaaattc ctgtaaatca tagtattgaa tccaataggc aattcttttt tccgtaactt   1503600
tagatgaaaa ataccttaac agttccaaat tttctctcag ggataaatga gataaaaact   1503660
cgactttttc aattaaaatt cctgcatcct gaatataatg attttttacc ccgtaaactt   1503720
taccatcttg aagaactttt cctttgtcaa gcttaatata accagcaagt atctttaaaa   1503780
gaaccgtctt gccagatcca ttatcacctt taagtccata aatttttcct gattgaaaca   1503840
ccaaattcaa ctgatttaaa ataggtcttt tcccataaat tttctgtcca tttataattt   1503900
caagtctcat cgtttatcct ttcttaaatt tctcttccaa gcgactaaca atcaacataa   1503960
ctaataaact taagagtact aaatacactg ttacaatatg atccatcatc cattcttgtc   1504020
ccacaaatgc taaaaaatag agaaaaaagg aaaaaccagc gcccgcacta atcagtgcta   1504080
tcagataaga cagtagtaag tacaacatca ttaactgagc aagtaaaaag aaaagtgcga   1504140
ctgttttgaa atgaattcct agaggaagta aaccaagaaa ccagacaaac aaatcttgag   1504200
taaaaaattt agaaatgaca accaatcgtt tccttgtata atcgaaaaag gagcttgatt   1504260
gatagcgaat caagtgatgg taatggtctg ccaaatcact ttcaagtaaa atgacagaga   1504320
gccatcctac catgaaaagc gaaaggttta acaatagttt ggggatttct aaattcgctt   1504380
cagaatagtc attataggaa aaaattgaaa tcaattctct cttgaaaaag ataacagcat   1504440
cctgcttttg aaccgctgtt gacaatagat ggtttatcaa aatcatcatc agaactatac   1504500
gaagtagtaa aacaatcttt ctatttagca aaatattgtt aaaattctta aacattatct   1504560
tcatattttt caagcaccat gtaagggaca atataaagga tataaggagt aaagagtttc   1504620
atcaaactta catccccata gctagcttgc atcaaactcg tcataggaac catatagtaa   1504680
ggcaaggcac tataaagcag catagaacca agccaaagaa acatcaaata ggtgattgcc   1504740
gaacgagtca cattccccac ataatcaact atttgtaaaa aatagattgc attgatgaaa   1504800
ataccgatta gtaggacaca agtaaagaac aaatagcttt ttatctctcc atctaggagt   1504860
ctttgtaaac cacttccatc agaaaataga gaattccatc caagaggaga aaaagtccca   1504920
aagaaatagg ttataattgc aattatcagc acagtcacta aatatatcaa acaagggata   1504980
cttgcaactt gcaaagtcaa ctttcttttt aacccttgat aactcacttc tcttccaata   1505040
ctcaatcgta aaactttatt tttcagctca atatattgaa aacctagcaa aacaatgatg   1505100
attggaataa taaatgattg ataaaaacct agattgaact ggagaatacg aaaatctaat   1505160
gctgatttta ataagtcatt tttaattgct tgtccatcga atttagctag atcgggcgca   1505220
tgaatatcaa aaaagaaata agtcatcaaa acatcacgat aaaccaaagc aagaaaaagc   1505280
aaagtaagca agacataaac aaatttatgc cttgcaaaag ttaagagagg aatcttcata   1505340
agccacctcc tacaaataga aagtaatata atactcaatg aaaatcaaag agcaaactag   1505400
gaaactagcc gcaagttgct caaagcactg ctttgaggtt gtagataaga ctgacgaagt   1505460
cagttacata tataatccaa ggcgacgttg acgtggtttg aagagatttt cgaagagtat   1505520
aaatcaatgc cttccgcctt tagacttccc tagttcccgt ctcaagtcaa gcattttttt   1505580
gaaaaagaca taggctaacc agtcactagc aaaagcgata agtagtaata atagccaaat   1505640
accccataac ttgatatctg tcaaatttct caagacgata ttgaaaaaca gaactgaaaa   1505700
aactgtccaa gcaaggctaa aaagagcata gagggtgatg taaatccagt aaaaatagta   1505760
aaaaattggg aaaaatttac tttctctatt atccttgtca atccagctga aaaagtaaaa   1505820
acagggtaat aagattatca ttttaaacaa gtgttccatc acaaacctcc tcttttaaat   1505880
tattttcttt agtttcgttc tattaaatgt tattaccaat ataaaccttg gaatagcgtg   1505940
taataaatga ttttagaggt accataagcc acctcctaca aatagaaacc gatataaatc   1506000
aatgccttcc acccttagac ttccctagtt cctgtctcaa gcgaaacatt tctttgaaac   1506060
aggaataagt taaccaattc ataccaatag ctagcagaat aaaaagaaac caaatgcccc   1506120
ataacttgat atctgtcaca tttctcaaga cggtattgaa aaacagaact gaaacaactg   1506180
tccaagcaag gctaaaaaga gaatagaagg ggatgtaaaa ccagtaaaaa taataaaaaa   1506240
ttggaaaaaa cttactattt ctgttggcct tttcaatcca gttatcaaaa taaaagtacg   1506300
gtgctaaaag taagaattta aacaaatgtt ccatcaccga catcccccct tcttttgata   1506360
gcgttttcta ttattttatt atatcaaaaa aatccggaac tgtcattcca gattctactt   1506420
ttttatttgc gttttcttgc gatgagatga atcggtgttc cctcaaaaac aaaggccttg   1506480
cggatttgat tttccaagaa acgcaggtaa gaaaagtgca tgagttcttc ttcattgaca   1506540
aagatgacaa aggttggtgg tttggttgcc acttgggtcg catagaaaat cttgagacgt   1506600
tttcctttgt ctgtcggtgt tgggttgatg gcaatggcat ccatgatgac atcgttcaag   1506660
acagctgatg gaatacgtgt attttgactt tcgctgattt gcttaatcat ctcaggaagt   1506720
ttgtggagac gttgcttggt taaagctgat acaaagataa tcggtgcgta aggcaggtat   1506780
tggaactgct cacggatatc ttcttcccag tttttcatag tgtggttatc tttttcaagc   1506840
gtatcccact tgttgaccac gataatcatc cctttaccag cttcatgggc aaatcctgcg   1506900
atacgcttgt cgtactcacg aatgccttct tccgcattga tgaccatcaa gaccacatct   1506960
gaacggtcaa tagcacgcat ggcacgcata acagagtatt tctcagtatt ttcataaacc   1507020
ttaccagact tacgcatacc agccgtatca atcatggtaa actcttgacc atctgtatct   1507080
gtaaagtggg tatcaatggc atcacgagtt gttccagcaa caggactagc aataacacgg   1507140
tcttctccca agatagcatt gatcaagctt gattttccaa cgttaggacg accaatcaag   1507200
ctaaacttaa tgacatctgg attttcttcc tcatattcat ttggaagatt ttctacgatc   1507260
gcatctagca catcccctgt accgattcca tggacagatg agataggcaa tggttcaccc   1507320
aaaccgagag catagaaatc atatatatca tttctcatct cagggttgtc caccttgttg   1507380
actgcgagga taactggttt gtgggtctta taaagcttac gagctacgta ttcgtctgca   1507440
tcagtaattc cttccttacc agacacgaca aaaacgataa catctgcttc ttccatggca   1507500
atttctgcct ggtgcttgat ttgttccatg aaaggagcat cgacatcatc aattcctcct   1507560
gtatcaatca tgctaaaaga acgattgagc cactcacccg ttgcataaat acggtcacgt   1507620
gtcactcctt cgacatcttc tacaatggag attcgctcac cagcgatccg attaaatagg   1507680
gttgatttcc caacattggg acgtcctaca atggcaatag ttggtagggc cataatttct   1507740
cactttctac aataatttct tctgttcaag attttttcta gttgagcttg gttcagcttg   1507800
accaaactgt tctgctaggc gctgactcca gcttgtggtc gcacgcgccc cagcatagtc   1507860
agcctgaaca cggtcataag cttggattgc ctcagttgac tgttcttggt attcttcctc   1507920
aaagacaaca ttctctagtg gcagtctcgg tttcatatca tgatgttgat ttggcacacc   1507980
cagtgccatc ccaaagacag aataggtgta gtcaggtagg ttaaagagct ctgccacttc   1508040
ttcagacttg tatcgaacca aaccgataat cacaccacca tagcccaagc tttcagctgc   1508100
caacaaggcg ttttgtccag caagagctgc atcgaccgaa ctaatcaaga gaccttccac   1508160
accttggggt tggaaggtgt cggtatgaag tcgggctccc ttttctgctc ggttcaaatc   1508220
tccgacaaag agaaggaaaa cagcagactg gcgaatggct tcttgaggta ccaattcata   1508280
caaggcatct ttcttctctt gacttcgtac cacaatcaca gagtaggatt ggaaattctt   1508340
ccaagatgat gccatctggg ctgctgtcaa aatctcattt aagtctactt ggggaatttc   1508400
ttgctcttta aacctgcgca ctgaagtatg agccttcatc aatttaatgg tttctgtcat   1508460
cgacggttta ctccttctaa acgagtctcc tcagccaaat aacggatgcg ttccatgacc   1508520
cgtctggctt cccaggtttc gtcatttcca tgtttcactt tcgcaaaatg cttctccaaa   1508580
tcttcaaagt tgaagttgga tgtgaaaaag gtcggtaaat tttcctgcat ccgatattgg   1508640
agaatgacct gcaggatttc gtcacgcacc caaacggttg attgctcggc gccaatatca   1508700
tctaaaatca ggacctcaga cagcttaatc tcatccacca aggtcttaac attgccatca   1508760
ctgatagcat ttttgacatc aatgacaaag ctaggatagt ggaggagagt tgatgaaaca   1508820
ccacgttttt ctgataaatc atgagctaag gccgccacca tgaaactttt acccacacca   1508880
aagtctccat ataagtaaag accttttcga atagctggat attgctccac gaaggctagt   1508940
agcttttcaa aaactggtaa gcgccccaaa tcatccaagt caacttgagc caaactagct   1509000
ttcttgagac tggctggtag attgattaac ttgagacggt tcttaatagc cgcttctttt   1509060
tcagccgcga ttagctcagg agtttcttca tatgaaacat ctgcataacc atgattctta   1509120
accaaaatcg gcttgtagcc tttggcaata taatccgtat ccccacggag aaacttgtca   1509180
cgctcggtga tgtactgatt aaacttggag atactgcgat ttaattcctt tggagttaag   1509240
gattcttgct ggataaaggc cgcaacatca gggtccttca tgattttctg gaccaaatct   1509300
tgataataaa aacggctggg ttgacgtttg agtacgtctc cgacactttc catctaatct   1509360
cctccttttt ctaatcgagc taatagttct tgcttcttac gttctagttc cagacgagtt   1509420
tcctcgctgg tttcattctt atattcagga ttactccatt taggaacatt ggttttttct   1509480
ggggcagtct gattctgttt ttgtgttttt gctttctgcc ctcgatcacg aattcgtaaa   1509540
acggcctctt ctgccgaatg aatcttttga taggcatagt cattggctac cttcatggca   1509600
tatttctcat tgatatttgc cgaatccacc ttattaaagg tcaataagag aataatattg   1509660
atgacttcgt ccagtaagcc caagccagcc atctgttgca agagttctct ttctgtttgg   1509720
gtaatggttc ccttgcgtgt ttgcttgatt tctgctaaga actgcagggc agttttactt   1509780
ttagcttctt tgataatggt cgcttcctta agactaaagt cagaggaaac tggtttttga   1509840
gcaatttttt cacgcatgcg tttggttgaa ataacctggg aaacagctgt tgacttggcc   1509900
aattgatagg tttcaaacca agtccatttc ttctcctcgg caatagcaaa gaggtttaag   1509960
acatcggact gctcatccgc aaaacgaagt ccatctcgag ccatcagctg gcgaaaatgt   1510020
tccaagtcaa aatcattggc cactttcttc ttgagaccaa ggtcttcttg actgcctagt   1510080
tctgccaatt ctggaaagac ttgattgagt gagacaggta tttcttcacc atcagcactt   1510140
tcaactttca aatcctccac agctacatcg ccaatctttt tctctaagag tctgcgataa   1510200
acaggatgcc ccaagaagtc ttgactagat agaggagcat ggagggctag ctgataaaca   1510260
tcaccctttt gatagagggt caagagatta aaagcagata agattttcaa tgattttatc   1510320
agtctatcca tcccaaagtt gagatggttg agaatgcttg aaaaaagata ttcctttcta   1510380
ccattatccc aaaaactgat tgtataaaga taaaggctca gtgcctcctg accgataatc   1510440
gggaggtagc actgtaccag agatgaggta tcttgcgaca cccgattatt ctttagataa   1510500
gaaaaacggt caattggctt catttatctt tcctttttct ttttagagga ctgggtgatt   1510560
tgttggagca agctctctaa ctcactgaca tccttaaaac tacgatagac actagcaaaa   1510620
cgtacatagg taatctcgtc caattcagcc aactcctcca tgacgagtga accaatgtcc   1510680
tcactttgaa tttcattttc atttcgacca cggagtttct gttcgatacg attgactacc   1510740
atgttgattt catcacttga cacaggacgt ttctgggctg agcggataat cccattaaag   1510800
attttatctc tggagaattg ttcccgtgtg ccatcttttt taacaaccac taaggttctt   1510860
tcttctactc gttcgtaggt tgtaaaacgg tgttggcatt cgtcgcactc acgtcttcta   1510920
cgaatggtgt tcccttcttc tgcttggcga ctatcgataa cacttgactt ggtagcccca   1510980
cattttggac aacgcatcct ttccctcctt atcgttttct tttcattata ccatttttta   1511040
agcgattccc aaaacaattc ttctttttgc ttgacaagtt ttttgttttg ttgtattatt   1511100
taattaagac aacaaggtaa aagaaaggag actaagatgt cctggacatt tgacaacaaa   1511160
aaacccatct atttacagat tatggagaaa atcaagcttc agattgtttc ccatacactg   1511220
gaacccaatc aacaacttcc aaccgtgagg gagctagcta gcgaggctgg tgtcaatccc   1511280
aataccatcc aaagagcctt atcagacctt gaacgagaag gatttgtcta cagcaagcga   1511340
acaactggac gatttgtgac taaggataag gagctaatcg cccagtcacg caaacaatta   1511400
tcagaagaag aattggaaca cttcgtttcc tccatgaccc attttggcta tgaaaaagaa   1511460
gaactaccag gcgtagtcag tgattatatt aaaggagttt aagcctatgt cattactagt   1511520
atttgaaaat gtatccaaat catatggagc aacaccagcc cttgaaaatg tttctcttga   1511580
cattccagct ggaaaaattg tcggccttct tgggccaaac ggctcaggaa aaacaaccct   1511640
gattaaacta attaatggcc tcttacaacc agatcaagga cgtgtcctca tcaacgacat   1511700
ggacccaagc ccagcaacca aggccgttgt agcttatttg cctgatacga cctatctcaa   1511760
tgagcaaatg aaggtcaaag aagccctaac ctacttcaag accttctata aagatttcaa   1511820
tcttgaacgc gcccatcatc tacttgcaga cctgggcatt gatgaaaata gtcgtctcaa   1511880
gaaactatca aaagaaaaca aagaaaaggt tcaactgatt ttggttatga gccgtgatgc   1511940
tcgtctctat gttttggacg aacccattgg tggggtggat ccagcagccc gtgcttatat   1512000
cctcaatacc attatcaaca actactcacc aacttctacc gttttgattt ctacccactt   1512060
gatttctgat atcgagccaa tcttggatga aattgtcttc ctaaaagacg gaaaagtcgt   1512120
ccgtcaagga aatgtagatg atattcgcta cgagtcaggt gaatccattg accaactctt   1512180
ccgtcagaat ttaaggccta agcaaaggag attatttatg ttttggaatt tagttcgcta   1512240
cgaatttaaa aatgttaaca agtggtattt agccctctac gcagccgtgc tagtcctttc   1512300
tgccctcatc ggaatacaga cacaaggctt taaaaatcta ccttaccaag aaagtcaggc   1512360
tactatgcta ctttttctag ctacagtctt tggtggcttg atgcttacac ttgggatttc   1512420
aaccattttc ttgattatta aacgcttcaa aggtagtgtc tacgaccgac aaggctatct   1512480
gactttgacc ttgccagttt ctgaacacca tatcatcaca gccaaactaa tcggtgcctt   1512540
tatctggtca ttgattagca ccgctgtatt ggctctaagt gctgttatta ttctggcttt   1512600
aacagctcca gaatggattc ctctttctta tgtgattaca tttgtagaaa cacatctccc   1512660
tcagatcttt cttacaggta tatccttcct actaaatact atttcaggaa tcctctgcat   1512720
ctacctggct atttccattg gacagctttt caatgaatac cgtacagcac tcgctgttgc   1512780
agtctacatt ggtatccaaa tcgtcattgg atttattgaa cttttcttca atcttagttc   1512840
taatttctat gtcaattcac tggtaggact caatgaccat ttctatatgg gagcaggtat   1512900
agccattgtt gaagaactca tattcatagc tatcttttat ctcggaacct actacatctt   1512960
gagaaataag gttaatttgc tttaaataat ttttacctag atatgtaaca tactcataga   1513020
acaaaagaga ccaggcaaaa agtctttaaa attagaaaac gcatagtatc aggtgttgaa   1513080
tatgtactgc cccccaaaag ttagattttt tctgtctaac ttttgggggc agttcataag   1513140
aaccttggta atatgcgttt tttgtgagct gacttatttc ctttcactat atcgcaaaat   1513200
gaaataagaa cggaacgatg ggattttgga attcaaatca atttataaga atgttttaga   1513260
agtaatatta tcctattcca gattcagttc actatacaat tgagttttca agcaacctgt   1513320
ttacataatg tgtacataat taggttcgtg attccaccct tttcaccttt aaaaacctcg   1513380
ctttcgcaag gctcttctat ttataagata aggcacgttt aaaggttttc caaatcccta   1513440
aatcatccgt ttgaagaacg agactagcat acatgcgtcc gataaatcct gttgctacca   1513500
ccgcaaaaat cactgtaata gcaagtgaaa tccatgcttc tgctcccccc gcatagtcat   1513560
taatcgttcg aaacggcata aagaaggtcg aaataaaggg aatataagaa ccaatcttca   1513620
agaggagatt gtcaccagct gcacctagag ctgtcactcc aaaaaaacca cccataatca   1513680
aaatcatcaa aggcgacaag gctttccctg agtcctcagg acgagaaacc atagatccta   1513740
ggaaggctgc caagactacg tacatgaaaa gactgatcaa aataaagagc aaggtattca   1513800
gtgagatagc atctcccaag tgatccaaaa taccagactg agccaagaat ggcaaatctt   1513860
taaagagcaa aacggcagcc agaccaccta caacatagat cccaatatgc gttaaaatca   1513920
ctagaaacag agccatcatc cgcgcataga aatagtgact tgcccttatg ctagaaaaaa   1513980
cgacttccat aattttggtg cctttttcac tggcaacttc ctgagctgtt acacccgcat   1514040
aggtaatcag aatcatataa agaaagaatc ctaaggcacc tgctgcaatt gtttgaataa   1514100
actttttatt ttccttggct tcatcaatct tttctgtgaa ttgaattgtc tgcgctaagc   1514160
gtttttcctg ctcttgagac aaggaagcag ttgaacgatt aagctgattt tgcagttcat   1514220
tgagtgtacc tgtaacctca aatttaattc cattttcaag cgatgtttcg ccatgataaa   1514280
ctgcctttag aacactatct tcttgatcaa tggtcaaata accttttaat ttttcttctt   1514340
taattgcttc tttggcactt gcttcgtctt tatagtcgaa gttaacacca tttacattct   1514400
tcagtccttc tgctacagat ggcactgttg tcactactgc cactttatta tttttagcca   1514460
tagaagaacc ttggagatgc ccaattccta cagagattcc taaaaagagg aacggcgaaa   1514520
tcaccataaa gaagaaactc catgactcga catgtcgaag ataggtttcc ttgattacaa   1514580
cccacatatt tctcatactt ccactcctga ttctagttta aagatttcat cgatagttgg   1514640
cgcttgttgg tcaaatgttg cgatatattg accttgagtc aagattgaga agagttccct   1514700
tccagcgctc tcatcctcca aaatcaattt ccaactgcct tgtttggtca agctcacctg   1514760
tttgacatga ggaagatttt ccaattcttc cttgcttcgt tcacttgaaa caaagagacg   1514820
cgttttcccg tattgattgc ggacatcctg aactggtccg tgcaagacca cacggccatc   1514880
tcggatcatc agaatatcgt cacaaagttc ctcaacattg gtcatgacat ggtcagaaaa   1514940
gataatggtt gctccgcgct ctttttcctg aaaaatgact tgtttgagca attctgtatt   1515000
aactgggtcc aatccactaa aaggctcatc caagataatc aggtctggtt catgaatcag   1515060
agtaataatg agctgaatct tctgctgatt tccttttgac agactcttga ttttatctgt   1515120
cagctttcct ttcacttcca acctcttcat ccattgaggg agtttttctt tgacttcttt   1515180
ggcatccatg ccttttagag tcgccaagta gcgaacttgt tcaagaactg tcaatttagg   1515240
catgagatgc gttcttcagg cagataacca atccgagcat aggtctcctg acgaatatcc   1515300
tgaccatcca gaccgatttc tccctgatat tctaggaatt tcaaaatact atggaaaatc   1515360
gttgtttttc cagcaccatt ttttccgact agtcccaaaa tacgacctgg tcgcgcttga   1515420
aagtcaatac caaacaaaac ttgcttggat ccaaaacttt tctctagact tcttacttct   1515480
agcatctttc acctccgaaa tttcttgcac tcattatact cctttttgat agcctttaca   1515540
atgttttttg tccattttta gaagactatt gctgtgtaaa atatggcctg gagcactttt   1515600
atactcaatg aaaatcaaag agcaaactag gaagctagcc gtagactgct caaagtacag   1515660
ctttgaggtt gcagataaaa ctgacgaagt cgactcaaaa cactgttttg aggttgtgga   1515720
tagaactgac gaagtcgata actatatcta cggcaaggcg aagctgacgt ggtttgaaga   1515780
gattttcgaa gagtattagt gataaatcca ttatacagca gcaaacttaa tttatacctt   1515840
ccgctcctca actgtctatt tttaatcctg aattgttatt tgagtaactc ctttttcctc   1515900
gtaaagtttt cttcctctaa aacttctgga aaaaggctaa tagtttcaga caacattttt   1515960
ataagaaaca agttcatctg tcatttcaag aaggagtaat cctttatcta ctaatggacg   1516020
gaacagaatt caaccgcttg tccgatatgt tttctaagga ttatatagta aaatgaaata   1516080
agaacaggac aaattgatca ggacagtcaa attgatttct aacaatgttt tagaagtaga   1516140
tgtatactat tctagtttca atctgctata tctattatgc acacccctat aggatctaat   1516200
gaaaatcaca acaggctcat tcatagatgg ttacctaagc ctaagggaac taagaaaacg   1516260
actaccaagg aagtcgcatt catcgaaaag tagattaaca actatcctaa aaaatgcttg   1516320
aactacaagt cccccagaga agacttctgg atgactaact tgaacttgaa atttagcaat   1516380
aattaattca ctatctaact atatttagta attatttcag aactgattaa tattaaaatt   1516440
aactaacaat tcaaaggatt catactagcc ataaattacg tccatcagag agagactctt   1516500
actactttta gattttagtc tttctagctt cagaatacat ctaaacttta gggaaaatga   1516560
ctattcgaaa gcgcgaatgc ctcaaaatta tctcagataa gctattcgaa acttagaatg   1516620
cttttaaatt tatggaattg cgattattcg aaacctagaa tgcatataac ctttagttga   1516680
cagacctatt ctaagtctcg aagggctatt tactttctat tccttatcaa aaaagactca   1516740
ttcccccttt ctcctccaaa atatggtata gtagaaatat actatctatg aggagtttac   1516800
atgtcacagg ataaacaaat gaaagctgtt tctccccttc tgcagcgagt tatcaatatc   1516860
tcatcgattg tcggtggggt tgggagtttg attttctgta tttgggctta tcaggctggg   1516920
attttacaat ccaaggaaac cctctctgcc tttatccagc aggcaggcat ctggggtcca   1516980
cctctcttta tctttttaca gattttacag actgtcgtcc ctatcattcc aggggccttg   1517040
acctcggtgg ctggggtctt tatctacggg cacatcatcg ggactatcta caactatatc   1517100
ggcatcgtga ttggctgtgc cattatcttt tatctagtgc gcctatacgg agctgccttt   1517160
gtccagtctg tcgtcagcaa gcgcacctac gacaagtaca tcgactggct agataagggc   1517220
aatcgttttg accgcttctt tatttttatg atgatttggc ccattagccc agctgacttt   1517280
ctctgtatgc tggctgccct gaccaagatg agcttcaagc gctacatgac catcatcatt   1517340
ctgaccaaac cctttaccct cgtggtttat acctacggtc tgacctatat tattgacttt   1517400
ttctggcaaa tgctttgaca cgtaaaaaat ccgtttggtt tcccaagtgg atttttaaag   1517460
cgtagattaa ctatagcttg atactaaata tactttggta tggaaatcat gcatattttt   1517520
cgatagtgag gcgaggactt acctagcctt tccgccgtga tagaaacacc tgaaatctaa   1517580
tggtttcagg tattcggaaa ctttgagcct agtgtctcaa agtttaggta tggaattttg   1517640
aagaaagtcg ctaccgtccg taatcactta aggaaaggct caaaaatatt gttttcaacc   1517700
acaaaatccg tttggtttcc caagcggatt ttgtgcttta ttttgaaact tcttttgcaa   1517760
gaacaaagtt cccaagtgtg gcagaaccat ttcctgcgac tgctggcgtc acgatatagt   1517820
cacgcacatc tggtactggt aggtaaccat taagaagaga tgtaaatttc tcacggacac   1517880
ggtccagcat atgttgttga gccatgaccc ctccaccaaa gacaatcacg tctgggcgga   1517940
aagtcactgt cgcattaacc gcagcttgag cgatatagta ggcttgaaca tcccaaacag   1518000
ggttgttgag ttcaatagtt tccccacgta cacctgtacg agcttccaaa cttggaccag   1518060
ctgcataacc ttctagacat cccttatgga aaggacaaac acccttaaac tctttttcaa   1518120
tatccattgg gtgtctagca acataataat gacccatttc agggtgaccc acaccaccga   1518180
taaactcacc acgttggatg acgcctgcac cgatacctgt accgattgtg tagtaaacca   1518240
agttttcgat acgaccacca gcattgttac gggcaaccat ttcaccgtaa gcagagctgt   1518300
ttacgtctgt tgtgaagtac attggcacgt ttagggcgcg acgaagggca ccaagcaagt   1518360
ctacatttgc ccagtttggt tttggagtcg tcgtgataaa gccataagtt tttgagtttt   1518420
tgtcaatatc aatcggccca aatgaaccaa ctgcaagacc agcaaggtta tcgaattttg   1518480
agaagaactc aatggtttta tcgattgttt cgattggagt tgttgttgga aattgtgttt   1518540
tttctacaac gttaaagttt tcatcaccga cagcacagac aaactttgta ccgcccgctt   1518600
ccaagcttcc atataatttt gtcatgataa acctcttgtt tttattttct ttattatagc   1518660
atacttcgaa agtctaaatg tctctatttt ttagattttc ctctgtaaat cttactatct   1518720
aataaaaacg aacaaacatg tcatttgttc gttttcacat tagagaggat tgattagatt   1518780
ttcacttcga tcacagcatc ccccttagca actgaacctg ttgcgactgg agctactgaa   1518840
gcgtagtcac ctgtatttgt aacgataacc attgttgtat catcaagtcc agctgcagcg   1518900
attttgtttg agtcaaatgt tccaagaaca tcgccagctt tcaccttatt accttgagca   1518960
acttttgttt caaaaccgtc accgttcata gatacagtat caataccaac atgaatcaaa   1519020
acttcagcac catttcttgt tttcaaacca aaagcgtgcc ctgttggaaa ggcaattgaa   1519080
acttcagcat cagctggtgc atagaccacg ccttggcttg gtttcacaac gataccttgt   1519140
cccatagctc cacttgagaa gactgggtca ttgacatcag caagagcgac aacatcaccg   1519200
acgataggag ttacaagtgt ttcattttga agagctgctg gcgcaacttc ttctttttct   1519260
tcagccactt cagctcgttt tgcagctgca gttgcgtcta cttcatcttc gtaaccaaac   1519320
atgtaagtaa gagcaaaacc aagggcaaat gatacagcta ccataagaag gtattgtgga   1519380
agttgtccgt taccaacata aagcattgta ccagggatga tggtgatacc attaccagta   1519440
ccagcaagtc caaggataga agccaatcca ccaccgattg caccagcaat caatgaaagg   1519500
aagaatggtt tacggaagcg caagttcacc ccgaagatag caggctctgt aatacctagg   1519560
aaggcagaaa gagcagccgg gaaagcaagt gttttcagtt ttggattttt tgttttaaca   1519620
ccaaccgcaa cagtagcagc accttgagct gtcatagcag ctgtgatgat agcgttgaat   1519680
gggttagcat ggtcagcagc aagtaattgc acttcaagca agttgaagat gtggtgcaca   1519740
cctgacacga cgatcaattg gtgaacccca ccaatcaaga aaccaccaag accaaatggc   1519800
atgctaagaa tcgcttttgt agcaataagg atgtagtttt caacaacgtg gaaaactggt   1519860
ccaatgacaa agagtccaag gatagacatg accaaaagtg tcacgaatgg tgttaccaag   1519920
aggtcaatga catctggaac aacttgcgga cagctttttc aaatttagct ccgacaaccc   1519980
cgatgatgaa ggctggaaga acggaacctt gcaaaccaac aacagggatg aaaccaaaga   1520040
agttcatcgc tgttacttca ccaccttgag caactgccca agcgtttgga agtgagccag   1520100
agacaagcat cataccaaga acgataccaa cggcaggatt tccaccaaat acacggaagg   1520160
ttgaccacac aaccaaacct ggcaagatga tgaaggctgt atctgtcaag atttgtgtgt   1520220
aagttgcaaa gtcacctgga agtggcattt caagagcgtt gaaaagacca cgcacaccca   1520280
tgaagagacc tgtcgctacg ataactggga tgattggaac gaaaacatca ccaaaagtac   1520340
ggatagcacg ttggaaccag ttcccttgtt tagcaacttc tgctttcatg tcatccttag   1520400
atgatgttgg taatccaagt acaacaactt catcgtacat tttgttaact gtacctgtac   1520460
caaagataat ttggtattgc cctgagttaa agaaagcacc ttgaactttt tccaagttct   1520520
caatcacttc tttattgatt ttctcttcat ctttgaccat gacacgtaga cgagtcgcac   1520580
agtgggcaac actattgaca ttttcacgtc cgcccaaggc atcgatgact ttttttgcaa   1520640
tttcctgatt gttcatttgc aaaaatctcc ttatataaca ttttgttctt gtttgaaagc   1520700
gattttattc gcccttacga ctattatttt atcatgtttt aaaaatatgt caagcgtttt   1520760
gcagaaaaaa attctatcca cttagtgggc aagctttaga ttgattgttt ttgactgttt   1520820
catcaggaat tccttgaaaa ataagtttga aaccttggtt aaaaagtatt ttatttcatt   1520880
atctttcaca ttttcgtaaa aatttgattg atttcctgta tttattttat gataatcctt   1520940
tgacagtttt tcctcttttt taacataaaa ggcttgcatt ttttatcgaa aacagttact   1521000
attaaaagtg ataagatttt tggaggaatg aatggaatgg acaactgagc gtcgttacag   1521060
actttatcaa gattggacgc aagaagaaat tcaacatata aaggaaaata tggcacaatc   1521120
tccatggcat actcattacc atgttgagcc aaaaacagga cttctcaacg acccaaatgg   1521180
cttttcttac tttgatggca agtggatcct cttttaccag aattttcctt ttggtgcagc   1521240
ccacggttta aaatcttggg cacagctaga aagtgatgat ttgattcact ttaaagaaac   1521300
tggaatcaaa gttttaccag atactccatt agatagccac ggtgcctact ctggttctgc   1521360
catgcaattt ggcgataact tattcctatt ttatacagga aatgttcgcg ataaaaactg   1521420
gatccgtcac ccataccaga tcggtgcttt gatggacaag gagggtaaga ttacaaagat   1521480
tgacaagatc ttgattgacc agccagcaga ctctactgac cacttccgcg atccacaaat   1521540
ttttaacttt cagggtcaat attatgccat tgtcggcgga caagacttgg agaaaaaagg   1521600
tttcgttcgt ctctacaagg ctgtcaataa cgactacaca aactggcaag cagttggcga   1521660
ccttgacttt gctaacgacc gtactgccta catgatggaa tgtcctaatt tggtctttgt   1521720
agaggaacaa cctgtccttc tctactgtcc acaaggattg gataagaaag ttctagacta   1521780
cgataatatc tttccaaata tgtataagat cggggcttcc tttgacccta aaaatgccaa   1521840
aatggtagat gtgtctcaac ttcaaaacat ggattacggt ttcgaagcct atgcaactca   1521900
agccttcaac gctcctgatg ggcgtgctct agcagttagc tggcttggtt tgccagatgt   1521960
ttcttaccca tctgaccgtt ttgaccacca aggaaccttc tctttggtca aggaactcac   1522020
tatcaaagac gacaagctct accagtatcc agtcgctgct attaaggacc ttcgtgcttc   1522080
tgaagaagcc ttctcaaacc gttcccaaac caagaacact tacgaacttg aactcaactt   1522140
ggaagctaat agccagagcg agattgtctt acttgctgat aaagaaggta agggactttc   1522200
aatcaacttt gaccttgtaa acggtcaagt aacagtggat cgtagccagg ctggagaaca   1522260
gtatgcccaa gaatttggga caactcgttc ttgccctatc gagaatcagg ctactactgc   1522320
tacaatcttc atcgataact ctgtctttga aattttcatc aataaaggag aaaaagtatt   1522380
ttctggtcgt gtcttcccac atgcggacca aaatggtatc ctgattaaat ctggaaaccc   1522440
aactggaact tactatgaat tagattatgg tcgcaaaact aactgatgtc gccaaacttg   1522500
caggcgtcag tcctactacc gtttctcggg ttatcaataa aaaagggtat ctatctgaga   1522560
aaaccatcca aaaagtcaat gaagccatgc gagaattggg ctataaaccc aacaacctgg   1522620
ctcgtagtct gcaaggaaaa tcagctaagt taatcggctt gattttcccc aatatttcca   1522680
atgttttcta tgcagaattg attgataaat tggaacacca actcttcaaa aatggttaca   1522740
agaccatcat ctgcaacagt gaacatgatt ctgagaagga acgcgaatac atcgaaatgt   1522800
tggaagccaa tcaggtggac ggcatcattt ctggtagtca caacctagga atcgaagact   1522860
acaatcgtgt gacagcgccg attatttcct ttgaccgaaa cctatcgcca gacatccctg   1522920
tcgtctcctc tgacaactat gctggtgggg ttcttgctgc ccaaaccttg gtcaagacag   1522980
gtgcccagtc tatcatcatg attacaggga atgacaattc taattcgcca accggactgc   1523040
gccacgctgg ttttgcatcc gtactcccaa aagctcctat tatcaatgtt tccagtgact   1523100
tttctcccgt cagaaaagaa atggaaatca agaatatctt gacccgggaa aaaccagatg   1523160
ccatttttgc ttcggatgat ttgacagcta ttctggtcat taaaatcgct caagaattgg   1523220
gcatttctgt cccaaaagag ctcaaggtca tcggctatga tgggacctac tttatcgaaa   1523280
attactaccc tcaattggct actatcaagc aacctttgga agagattgct tgtctcacta   1523340
ttgatcttct cttgcaaaag attgaaggca aggaagtcgc cacaactggt tacttcttac   1523400
cagttacgct attaccagga aaaagtattt aaacacaaga aaactcagac cgattcgtct   1523460
gagtttttat gatcttaaat tttcgagata gcgctgggct gtctctaggt taaaggtttt   1523520
atctgagatg aggcgctcta ctaggggagc aacttcagat tcactagccc cagctaggag   1523580
agctagggat ttggcctgta gtttcatgtg gccttgctgg atgcccgtac ttaccaaggc   1523640
tttgagggct gcaaaatttt gagcaagacc gatggacacg ataatctggg ctaattctct   1523700
ggcagaagga tttcctagta gatcatgact gagaactaca cgtgggttga ggccgataga   1523760
gccaccctta gtcgctacag gcatgggcag ggtcatctca ccgaccaatt cttctctttc   1523820
aaggtccagc gtccagcagc taagaccttg atagcgtcca tctcgactgg caaaggcatg   1523880
ggccccagct tcgatggcac gccagtcatt accagtggca atcaaaatcg catcaatacc   1523940
attaaaaatt cctttattat gagtagcagc tcggtaagga tcagcctgcg caaactgact   1524000
agccaacgca attttctccg caatctctcg tccttgatcc ttttggcggc tcaagtagcg   1524060
aaaggcgatg cgacagcttg cagtcaccag agaatcggtc gcgtagttgg acaggattcc   1524120
catgagactc tgtccctgac tgagttcttc taagactggt ttcaaggctt ccagcatggt   1524180
gttgagcata ttggcaccca tggcttcctg ggtatcgaca tgaatataaa caacgagaaa   1524240
gtctggttcg ccttttatct gctcgacatg cagatcacgc gccccacctc cacgtttaac   1524300
gatagaagga taggcttgat tggcaagctc caagagctcc gctttcttgc tggcaatctt   1524360
ctcttgcgct agtttaggat tagcaacttg ataaagggct acctgcccaa tcatctgtcg   1524420
ctgatggact tgtgcagtaa aaccacctgc acgcttgatg attttgctgg catagctggc   1524480
cgccgcaacc acagagggtt cttctgtcac atagggaacg gtgtattcct gaccgttgac   1524540
aagtacctcc ggaaccagtg aataaggcag agaaaaagtt cccactacat tctcactcag   1524600
ctggtctgcc acagtcacgc tcatctgttc atccttctcc agactagctt gtctctcagg   1524660
actaaggagc gcctgagctt ttaacagctc gaggcgctct tggtatgatt ttttagaaaa   1524720
tccattccaa cttatcttca ttatttttca accttgctat aacggcgttg gtggtcgaga   1524780
atttcaacca aggcaaaatc ttgattttca tagccagcaa actgggcaga gttagtttca   1524840
tccaagttta cttcctcaaa aaagaccttt tcatagtctg caacggatag ggcagttcgt   1524900
tggttgagct tgttcaaacg gtctttatcc aaataagctt catatccttc aaccaattca   1524960
ccactgaaga actcagccac agctccactt ccgtaactat aaagggcgat tttatcccca   1525020
gctttcaagc tatctgtatt ttccaagaga gacaaaagtc caaggaaaag tgaacctgtg   1525080
tagatattcc ccaccttttg actgtagaga atagactggt caaaatgctt ttgtaagagg   1525140
tcttttttct cttgaggcag gctcttatcc atgatttttt tcaagccttt tagcgctaat   1525200
ttaggataag gcaagtggaa acaaacagcc gcaaaatcat ccaaagtaag ctggtagcgt   1525260
ttttgatatt caagccaagt cgttttcaaa ctatccaagt attgttgggt agaatagaca   1525320
ccatttacat aaggagttgt cgagtaattt ggtcgccaga aatccatgat gtcacgggtc   1525380
tgagctacat tgtcattatt aaaggccatc atgcgtggat tttgtgtaat caacatagct   1525440
acacttccag caccttgagt tggttctcct ggagtttcaa taccgtattt ggcaatatca   1525500
ctggcaatga ccaagacctt ggactccgga gaattttcca catgcaattt ggcataatgg   1525560
agggcagcag tcgctccgta gcaggcttct ttaatctcga aactacgagc aaagggctgg   1525620
atgcccagca agccatgcac aaagacggcc gcagccttac tctggtcaat tcctgactcg   1525680
gtcgccacaa tgaccatgtc aacttcttgt ctttcttgct cagttaaaat agagtcacta   1525740
gcactggccg ccaaggtcac gatatcctca gttaggggcg caatactcaa ttccttgagt   1525800
aagagtcctt tacttaattt ttcagggtca attcccctcg cttctgctaa gtcttgtaat   1525860
ttcaagacat attgactggt cgcaaaacca atcttatcaa taccgattgt catatttacc   1525920
tctgttttat cattcatgta aaaaatcgtt ctatactatt ttatcacaaa tggcagtaaa   1525980
agagagaaaa aagacttgat tcaccaaatc aagcctctta ttggtcatca ttttaaagaa   1526040
tgattagttg ctagagagtt caccgatata agtagcttta taagctccat tcacagttat   1526100
cagctcctgg aggatcaaat ttcctgagta agtccttccc atctcatcta caaatttttg   1526160
ataaaactga ctggtcggaa tttctctgac atccttatca aatgtcttat caagtgtttt   1526220
actaaccttc tcagcaatca attgatgctc ttgccatcca ctttgaaact ctgagcccga   1526280
actagaaacc atgactggga taaacaacaa ggtcagtaga tttacagaca ataaggaaag   1526340
tagtagactt cctgcaaaac tagaatccta gttcatgatt gataatacca gcaatcaaat   1526400
tcattcgtaa tccgaagcgt ttacgatgat ttcgataggt tgttgaaaac attttaaacg   1526460
tttttacttt ggcaaagatg ttctcaacct tgcttctctc cttagatagc gcatggttac   1526520
aggctttatc ttcagctgtt agcggcttga gtttgctgga tttacgtgga gtttgtgctt   1526580
gaggatatat cttcatgagc ccttgataat cactgtcagc caagatttta ccagcttgtc   1526640
cgatatttct gcaactcatt ttgaacaact tcatatcatg actatagttc acagcgatat   1526700
ccaaagaaac aattctccct tgacttgtga caatcgcttg agccttcata gcgtgaaatt   1526760
tctttttacc agaatcattc gctaattgtt ttttagggcg attgattttt acttccgtca   1526820
catcaatcat tatcgtgtcc tcaaagctga gaggagttct tgaaatcgta acaccacttt   1526880
gaacaagagt tacttcaacc cattggctcc gacggattaa gttgctttcg tggataccaa   1526940
aatcagccgc aatttcttca taagtgcggt attctcgcac atatagaaag cgttatcaat   1527000
ttatttatct catttttcag aaaattcttt tatttctgta aagtctacga tactcgatgt   1527060
gtttttatat aatgatagag tctgagaatc actgttccgc tagccattcc aatagagatt   1527120
accaaagcca acatgacaac caaggtcgca cttgccagtg ctttattata gtcccctgtc   1527180
acaaaaaagg cagttgttcg gtaggagaga taacctggaa ccagcggtgc caaaatggcc   1527240
aagataaaga ccacagcagg tgtcttataa agaatactta aaatctggct gacacaagaa   1527300
ccaataatgg ctgcaatgaa ggtagctaca atgacattgg tcggttcctt gagcaagaga   1527360
tagattagcc agacagtcat gcccaaaatc cctccaggta agagcataga ccgttgcaca   1527420
ttgagtacga ttaaaaaagt gataatggca agaaaacttg ctactgcttg taataaaaag   1527480
gttgttagtg tcatattagt tcatcaatac caaggcgaca gaagttcctg cccctaaagc   1527540
gagggtaatg agcagggatt caaacatctt actcatacca gagtttatgt ggttggtcat   1527600
aatatcacgg accgcattgg tcaaggcaat acctggtaca aacggcatga ccgcaccagc   1527660
tataatcaaa tctgccgttg aaggaaaacc tgtgtagcga gcccaaaact gggcaattat   1527720
cccaaagaca aaggctccag caaaggctgt cacaaaggga attcggataa atttttccac   1527780
atagagggaa aaggcaaaac caaataaggt cgccactcct gccccaagtg cgtcgtagat   1527840
atttccgcta aacataactg aaaagaaagg agcactaaag gtcgcagcca gagttacctg   1527900
caacttagta tagggaaggg gtttggcttg caaggccgtc aattgcttaa aggctgtttc   1527960
taagtcaatc tgccccccaa ctagctgacg agaaatctgg ttcacatcgc agactttttc   1528020
gatgttataa gaagaggagg tcacgcgctt catgcgcgaa atattggtat tttcaataga   1528080
gaaaaagata gcggcaggca tggcaaggac attgcaatcc acaatcccct gcgaatgcgc   1528140
gattcgaatc atggtatctt ctacacgatg gatttctgag ccacttttaa ggagaatagt   1528200
ccccgctagc ataatcacat caatgacggc atttaattct tttgattctt ccatgctttc   1528260
ctccttttat caactccctc tattctatca caaatccgga ctcaaaaaaa atctttgcca   1528320
tgaaatcatg acaaagattg attactcatt ttgattatcc atctgctttt aaggagtagc   1528380
tgaagttgtt ttaggtttgt agattgaaat cttgactcta gtcttattga ggtctacctt   1528440
ttcacctgct ctaggacttt gttcaacaac catgccttct gcactacctg caggcgctgt   1528500
cgtcacttct acaacttcta tattagcttc cttaatccca acaatttgaa tcaaattgtt   1528560
cttagtaaac tccaagctag aaccaatgta actcggcatg gcaacacttg taactttttt   1528620
agctactgtc aagacaattt gagtaggttt actcacatca taagtcgttc cggcacctgg   1528680
actttgtttc ataatcgttc ctggttcgct ttcgctggac tcttcttcct ctatcttaat   1528740
caaattctca ggaaccttct tctgcttgag ttctgagatt acttctgtag agttccgtcc   1528800
aatatagttc cctaattgaa tcgtcgtagc ttttttagct actgtcaaaa caatttgagt   1528860
tgccttgctc aagtcatagg tcgtaccttc tggtagactt tgcttcagga ccgttccagc   1528920
ctcactctca ttcgactctt cttcctcaat tttaatcaaa ttatctggaa cttttttctc   1528980
ttttaattcc gcaatgacat cagaggattt ccgaccgaca taattactaa tttggaaaga   1529040
ttgcttgcct gatgagacaa ccaaattgat tttcgttcct tcttttcgac cagttccagc   1529100
gccaggatct gtacggataa tccgcccttc ttccaccttt tcactagcct ctgtcttctc   1529160
ctcaccaatc tcaaaattgg cttttttgag cgttgccttg gcctctgcaa ctgtctgacc   1529220
tgccacatct ggaatggcaa tggttgcagg agttctggat agtatccaaa taagagaagc   1529280
tgccaccaat acaaggctgg ccaacaaaat caggtaacgc atcttaaatc tatgtttttt   1529340
cggtgcttgt ggttggtaag tttcctctgt cacagcctgg cttgggtttt tgattgattt   1529400
gtgttctgtt tgcgcttgaa ccttaggaat agatgtcaag gtactctgag aaaccttcgg   1529460
caaggtcttg gtatctgcct tgctcgtttc atcaaagatt aacttacttt catttctacg   1529520
attgtaggac aagctactag acaagtccac atacatctct gaaaccgagc ggtagcgatt   1529580
ggtcaacttt ttagcagttg ccttgataat aacattttct aaagcctgag gtacagatgg   1529640
attttctgca ataacggacg gcaggggttt ctggaaatgc tggagggcaa tggtcaccgc   1529700
gctatccccg tcataaggga tatggcctgt cagcatctca tagaaaataa tccccatggc   1529760
atagatatca ctctgcacag tcgccttcga accacgcgcc tgctctggtg acaagtaatg   1529820
aactgagccc aacatcgagt tagtctgggt cagacttgtc tctgcaaagg ctacagcaat   1529880
cccaaagtct gtgaccttgg cagtcccatc tggtgtcaag aggatatttt gaggtttcaa   1529940
gtccctgtga acaattcctc gagtatgggc caagcgcata gccaagagaa tttgtcccat   1530000
gatacggact gcttcttcat tagaaagagg ataatgttcc ttgatatagc gtttgaggtc   1530060
cagtccagcc acatactcca tagctaggta ctgttgaccg tcttcctcgc caatatctgt   1530120
tatccgaacg atatgaggat ggtctagatc tgccatagct ctcgcttcac gctgaaaacg   1530180
agctacagct atcgggtccg tctggtagtt ggtcctcaga accttcactg ccacttcttc   1530240
cccatctaag attaagtctt tggctaggta gacatccgcc atacctcctc gaccaatctg   1530300
tttgacaatc cgatagcgtc cggcaaaaat cttgccgatt tggatcattc tgcatcctcc   1530360
tcgttcatag aaacaagggc aaccgtaatg ttgtctaaac ctcctgcatt gttagcaaaa   1530420
cgaacaagtg tctccgtttt atctgctaaa ggaatatcac tggttacaat atcacgaatc   1530480
tcactgcctg aaatcatgtt ggtcaagccg tcactattga gcaagagata gtcacctgac   1530540
tcaaggataa ctgtcccaaa atcaggctga atttcatctt tttgcccaat agactgggtg   1530600
ataatatttt tttgcggatg agcttctgcc tcttctggtg tcaattgacc agccttgagc   1530660
aattcattaa ccaaggaatg atcgctcgtc aactgatggt attcttctcc acgaatcaag   1530720
ccgatacgcg aatcaccaat atgagcatag atagcctgat tatcaataat agcaaggact   1530780
tccaaagtag ttcccatgcc tctgtaagct tcatcctgac caagctggtg aatcttttga   1530840
ttttcaattt ctaggtaatg ggcgaaccat tcacgcactt cattgactgt atcgatctgg   1530900
gtatcaaccc aagctacacc caggtctgtg accgccattt cactagcgat attccctgcg   1530960
cgatgacctc ccatcccatc agctaaaata atcatggtac gtccagctct attgacatag   1531020
tggttgacat agtcttggtt atttgttcgt ttctgaccaa catctgttaa taatgaaatt   1531080
tccatgtgtc agttccttcc taatccgata tcttgcgaaa ttgactgatg aagaatccat   1531140
cacttccata caattcaggt gtaatgagga tacagccgtc tttcatgata tccttacatt   1531200
catgttctag ttttacctgc tcgaactcgg gatgactctc taaaaaggcc ttaacgactt   1531260
gaaaattctc ctctgagacg atagtgcagg tgctataagt tattatacca cctttgccta   1531320
gtatttgaca aacactacct aatatttcta actgaatttc ctgcaaggac gcgaaatctg   1531380
ccgtttcttt attgtatttg atatctggtt ttcggcgcaa aagaccgatt cctgaacaag   1531440
gagcatccac caaaatctta tcaaaggaat cctggtcaaa aaactcatgc acctttctgg   1531500
catccaattt ttgagtttga acccgatctt caactcccag acgttgggca ttttcttgaa   1531560
ttaaatccaa cttgtggtcg tacaagtcca gagcagtaac ctgacctgtc gtaagataag   1531620
aggctatatg ggctgttttc ccacctggag ccgcacaggc atcaagcact cgctcatcac   1531680
cttgtaaatc aagcgtcgga gcaaccagct gactggactc atcttggatg gtaatggctc   1531740
catccgcaaa caaattatgc cctgcaaaat gcccctgctc cttaaccaga ccagtggttg   1531800
ctaaaaggga attattcgcc tccaacaagg cttggatttc ctcttttcga cttaggtctg   1531860
ttacacgaat actggctttg tttcgcacta acaggctttc aaagatggct tttgctctct   1531920
cctctccgta ttcttccttg agtttggcaa ctagccaaac tgggagagaa taggcaatgg   1531980
agtcacgctt gttttttcgc ttgatgctag caatatctgg ccagccttca cgcaagatac   1532040
ggcgaaggac agcgttgacc aatttttcac tgcctttttt acggagtttg gccaattcca   1532100
ctgcttcatt aaccacagca tgatctggaa tcttgtccaa atagcggagt tggtaggcac   1532160
tcatgagaag aaggacatag agccagctgt ctaactggtc tctgtcttcg ataaagtggg   1532220
ataggtacca ttccagagtc agtttacggg ctaccgttcc atagaccagc tcggtcacta   1532280
agcccttgtc tgctgccaaa agttgacttc cctttagatg cttatttaag gcgatatttg   1532340
aatatgcttg gttcacaaaa acatcctcta gcactgctag agctaaactt ctagccgttt   1532400
ctactttagt caccaaatcg ttctcctaca gtcaatgtac gtccaactcc gttgaggaag   1532460
gaagcaatgt ccatcttagg cttaccagct ggctgcactt gtttgaggga tagagcccct   1532520
tcagccgttg cgacaatcaa ttctttcttg ccgatagaga gaatctcacc tggatttccc   1532580
tgaccttcta ctggtagggc ttcataaatc ttaaagcggt cgcccttaag gaaagtatgg   1532640
gcaacaggcc aggggttcat tccacgaatt tggttaaaga gttgacgatt ggttttgttc   1532700
cagtccagtt tttcttcctc tggctttata tttggagaga aggtaacctg actcgtatcc   1532760
tgcggttcag gtttgatatc accagcaata taggcaggca gagtgtccaa aagcaaatca   1532820
cgaccaacta gcgccaattt ttcaaacaag gtgccaacat tgtcctcatc tgtgatcgga   1532880
atgctgcgac gagaaatcat atctcctgca tccatttcct taaccatttc catgatggtc   1532940
acaccagctt cctcatcccc ttgaatcaag gcataatgga taggcgcacc accacggtgt   1533000
ctaggaagga gggaggcatg aacgttgaca gcaaagtcca tgctatcaag gagtttgctt   1533060
gggagaaact gcccaaaagc agcagtcaca attccatctg ctcctagctt cataagatct   1533120
tccatctctg gacttccaga taatttttca ggttggtaga tagatagtcc tgcttccttg   1533180
gcagcctgct tgactggggt ttcttggata acttttttac gaccaacagc acggtctggc   1533240
tgggtcacaa cggctagaat ttcgtaacgg tcatctgtca aaagtccttt taagactgtt   1533300
gctgaaaagt cgggggtccc cataaagatt agttttgtca tatcttctcc ttcttataaa   1533360
aattgctgcg gctcatggtc aatgctgaga cggagctcac tattttcccg ttcttgagtc   1533420
aaggctaaaa cctggttgag ggtcgacccc agctcatctt ctaaacggta tttaattaaa   1533480
atctggtaat gatagaggtt gtgggtacgg gcaatcggtt ttggcgttgg ccccagaatg   1533540
ggactggtct ctgacaagcc tgaccgcaaa atgttcatga cttcataggc acgtttgaaa   1533600
acctcttctt ctttcttgtg agaaagggta ataccaatcg tgaaatagta aggtggatag   1533660
ccgagttgtc gtctgattcc catttcatag gcataaaagc cttcgtaatc ttgatccttg   1533720
gcaaatcgaa tagcatagtg ctgcggattg taggactgta tcaagacttg acctgccttt   1533780
tcagcccgac ctgatcgacc tgccacctga gtcaagagct ggaaggttct ctcagaagaa   1533840
cggaaatcag gcagattcaa ggccgtatcc gcatttagaa ctccgactag ggtaacattg   1533900
ggaaaatcca aaccctttgc aatcatctga gtaccaagta aaatatccgc ttcccctcgc   1533960
ccaaactggt caagcaaggc ttggtgactg cctttctttc gagtcgtatc cacatccatc   1534020
ctcagaatgc gagcttgggg aaagagttct gctagctcat cataagcctt ctgagttccc   1534080
gtcccatagt aacgaatact gcggctctta cagttaggac agacctgagg aatatccttc   1534140
gagaaaccac aataatggca gttcatagtc ttggtatcca tatgcaaggt cagagaaata   1534200
tcgcagttgg gacaagtatc caccgtccca cactcccgac acatgacaaa gctagaataa   1534260
ccacggcgat tgagcatgag aaccacctgc tcttttttaa ccagacggtc ttggatagcc   1534320
tctagcaaag gaggcgtaaa gtttgacgtc tcattttgtc cgatatagtc tcgaaagtca   1534380
atcacttgaa cctcagggat tgtagccaaa ggattggcac gttgggttag acgtaagtgt   1534440
tgatagacgc ctttgccagc acgtgcccgg ctctctaagc tcggcgttgc agatccaagt   1534500
accagagttg cttgattata ctgagcccgt aaaatagcta cctctctggc atggtaacgg   1534560
ggattgctgt cctgcttata agccgcttca tgctcttcat caataatcat gacacccaga   1534620
tttttcagag gagcaaagat agcagatctg gcaccaacaa caacttgggc atcgccacgc   1534680
tccaccttgc gccattcatc atacttttca ccattggata atcctgagtg aagaatggct   1534740
accttgtccc caaaacgtgc tataaaacgc tcggtcatct gaggagtcaa ggaaatctca   1534800
ggtaccagca aaatagctgt cttgccctta tccagggcac cttggataat ctgcaagtaa   1534860
acctcggtct tcccacttcc tgtaatccct tgaagtagaa agggaggttg agaactgcca   1534920
atagaactca caaccgcatc acgcgcctgt ctttgttctg gatttaactc caaaggtcta   1534980
cttgcttcaa ttccttcaaa ataagcagcc gagcgttgaa cttccttttg gactatggta   1535040
acagcacctt gatccacaaa gaagttgact tgctctcgcg agtaggactc taacaagcta   1535100
gccaaggaag cgctctctgg atgagacagc agataatctc tcagttccaa ctttttcttg   1535160
gcacgtgtag aaatctcaac accttctaat tgagcatggt caacctcata ccaagactgg   1535220
gtcttgacct tcttttgatc gactgcctga tattccagac caagcaggcc ttttctagtc   1535280
aaacgcatca tttcagcttg cttggcaagg tctagtgaag aaaaggctag cgaatcttct   1535340
gaaccaaaca ggcgcactcg ttcttcctga ctcaagcctt ccagaggata gagaatcttg   1535400
tcatagctag aattcagaaa ccctggaagc atggccttga ggatagagat tttgtaggag   1535460
aagacagatt tgcgtaactc ctcagccagc cagagttgtt ctggcgtgag aacaggagaa   1535520
aaatccagca cctctgcaat atcttttaaa tcttgctcca tctcttctcc atctgattgg   1535580
gacttcaaac caagaacaat cccttgaatc aggcgattac ccttaccaaa aggcacatga   1535640
acccgcatcc caacttccag cattccctca aattcctccg gaatcctgta actatagggc   1535700
tggtccgtct gcatcaaggg cacatctacg ataatcttag ctagggccat cttctcacct   1535760
cctccttgtc agtacattct tgcaatagaa aaaataagat tgagtccccc caaccttaaa   1535820
ttttttcacc atcttctttt tctttagcaa tttgctcttt gattttcttt tcttcttctt   1535880
ctttgcggcg tttttcttct tcgatacggc gacgcactgc ttcacgtttt ccttctggat   1535940
ctgggtgaat tgtaacgttt cctgattcga tttcttctaa agcgcgaaga gttgattttt   1536000
cagacttgaa accttgagtt gctggggcac ctgcttccaa ttcgtgggca cgttttgctt   1536060
ccaagattac gagtgaatat tttgaaggaa ccttgtcgag caaggtatca atagagggtt   1536120
ttaacatcat ttgcttgtac ctattttcta aattttatcg ggtagttgga gattttggta   1536180
acatctcctg atagtgacca atgacacgat ccacacagaa gtgttctgct tcaatcacac   1536240
atttgacacg ttcagcagct aggggtacct gatcgttgac aatcgcataa tcatactcac   1536300
gcatgagggc aatttcttcc ttggcctttt cgattcgttg ggcaatcact tctgcactat   1536360
ctgttccacg acctaccaag cgatcttgca attcatccaa atctggtggt gtcaggaaga   1536420
taaagacagc atctggaacc tttttcttga cctgaagagc accctgaact tcaatttcaa   1536480
ggaaaacatc gattcccttg tccaaggttt cattgacata ggtcagagga gttccatagt   1536540
agttaccgac atattctgcg tattccaaca tctgtccttg acgaatcagc tcttcaaatt   1536600
cttcacgagt acggaagaaa tagtcaacac cgtccacttc tccaggacgt tgtgcgcgtg   1536660
tcgtcatcga tacagaatat tgaaattggt tttcagaact ctcaaaaatc tctcttctaa   1536720
ccgttccttt tccaacccct gaaggaccag aaaaaacgat tagtaagcct cggtctgcca   1536780
ttgtgtctcc ttttagtcaa tctgtgaaat aacatttctc tagaataatg gcaaaaagcc   1536840
agattatcct ttacagtctt tctatctagt gtaacaaaaa agcagtaatt tttcaactgc   1536900
tctttcttat ttatttagca taatctactg cacgaagctc gcgaatcacg gttaccttga   1536960
tatttcctgg ataatcgaga ttgttttcaa ttttcttacg aactttgtga gccaagattg   1537020
tgactttgtc gtccttgatt tttcctggat tgaccatgat acgaatttca cgtcctgctt   1537080
gaagggcaaa gctagtttgc actccttcaa agccgttagc aatttcttcc aaatcatgga   1537140
gacgcttgat gtagctttca agagactcac tacgagcacc tggacgggct gcgctcaagg   1537200
catctgctgc agcgacgata actgctatca cgctctcagc ttcaacatct ccgtggtgac   1537260
tagcaatcgt attcaccaca actgggggtt ccttgtactt acgggccaat tccataccga   1537320
tttcaacgtg gctaccttca acctcatggt caatggcttt cccgatatcg tgaaggaatc   1537380
cagcacgacg ggcaagagcc gcattttcac caagttcgct cgccatgata ccagccaact   1537440
tagcaacctc aatcgaatgg cgcaaaacat tttgtccata tgaagtacgg aactgcaaac   1537500
gtcccataat cttcatcaag tctggatgaa ggtttggcgc accaatttca taggcagcag   1537560
cctcaccgta ttcacgaatc ttattgtcaa tctcttgacg gtttttctca accaactctt   1537620
cgatacgagc tggatgtata cgaccatctt tgagcaacat ttccatagtc atacgggcaa   1537680
tctcacgacg aatcggatca aatcctgaca aggtcaccac ttctggtgta tcgtcgataa   1537740
tcacatcgac ccctgtcaaa ctttcaaagg tacgaatgtt acgaccttca cgaccaataa   1537800
tgcgtccctt catagtatcg tctggcagat gaactgttga gtttgttgac tccgctacat   1537860
attcaccagc gatacgttgc atagcttgaa ccaagatgtc cttggccatt ttgtcagaac   1537920
gttccttgac ctcttgctca gcttcgcgaa tgcgactggc aatctccctg gtcaagtttt   1537980
cctctgtctg agccaagata atatctcgtg cttctgcctg agacagcgca ccaatacgct   1538040
ctagttctgc ttctttttgt ctttcgactt cctctaattg ctcttcacgc gcatcaaggt   1538100
ttttcgctct atcagaaata ctttgttctt tttgttcaag tgtttgttct ttactcgtca   1538160
aattgtcgtc cttacggtca aggctagtag ctctctctgt caaacgactt tcgatttgtt   1538220
tgagttcttg acgttctgat ttgaattcag cgtccacttc ttcacggtat tttctggctt   1538280
cttctttggc ctccaatagt gcttcttttt taagagactt gctttcacgt ttggcttcat   1538340
taacaagtaa atccgcttca cgctcagctt gtccacgtaa attagttgct tcttgttcag   1538400
catttaaaag catcaactct gcagcttcct gagatgattt catcttagct gagatgctga   1538460
catatccaat gactaaacca atgatgacgg caaaaacagc aatcgcaagc gacatgattt   1538520
ccatgttttt acctcatttt attgttattc cgaatgacat acattctttt acattctacc   1538580
ataaaaaagt gattttcaca aacctaaaat agaatatgtt ttgaggaatt tggaacacat   1538640
ttaccaaaat aaacttgttg tttagaaata gtagtttagt agagacttga gaaaaagcct   1538700
acctttcaat agacttagta atgatcttta aaggacaaga aagccacgct atctccatcc   1538760
atcatataaa tcaagcgatt ttctgcatca atacgccgtg accaggctcc ttggtaatca   1538820
tatttgagtg gttctggttt acctattcct gtaaagggat cacgttgaat atccttgatt   1538880
agtttattga ttctttttaa cgttttctta tcctgatttt gccagtagca ataatctgcc   1538940
caggcatctt ctgtaaactt gagcagcatt tcttactcct caataacatg gacctgagta   1539000
cttccagcac gaacttgagc cattcctcgc aaaaccttat cagaaagttc cttattttga   1539060
gcaattctca gggtttcttg gatactatcc cactcactct ttgaaaggac tacaatgtcc   1539120
tcatctggat ttttattgac caccgtcaaa ggctcaaatt catcatttac cttcttcatg   1539180
tagtccttta aatgatttcg gaatgttgag taaaggactg cttccataac catacctcgt   1539240
tttagctctt ttccactatt atacacgaaa agaaagaaat tgtcaggaac ttgtacaaga   1539300
ttttcttttc tatctattta tactcaatga aaatcaaaga gcaaactagg aaactagccg   1539360
caggctgtac ttgagtacgg caaggcgacg ttgacgcgat ttgaatttga ttttcgaaga   1539420
gtattattcg taaaaaatct caaaaagcct acctttcggt agacttagtt tgtttctatt   1539480
ctaatcggca ctcttccaaa attttgctct gctatacttg gcttccctag ttggtaaatc   1539540
tggtctgctt tttgggtcat agcatcccaa ggttctttgc caattcggct gactagactg   1539600
acctgacctt tcaaagactt gagatgttgc ctaccttttt cagtaaatcc aaggacatga   1539660
atggcttctg gcaagtcact ttctctagcc tgcatcaaaa tataggtcaa taggcgtctg   1539720
acacgcgcct tggtgtaacg tttggtagtc actaactcga ccaattcttc cacagactgg   1539780
gctgttttaa tagcttcttt aatgcgcaca gccatttctt gattgacctg atagatggtg   1539840
gttaggtcgg gatttgacaa gatttgatag cggagcaagg gaaaatagtc ttcccagatc   1539900
accttactgg cctgctcaaa tagggcaaca gaaggcataa aacgttctaa gaaatcttgg   1539960
tccttctgat gttgacggag ggctgtcgcc gaggcaaagt ccacatcttt attcacagaa   1540020
tggtaacctg ccccctgacg ctgaatcgga tgcagcttga tattccgtcc tgcaaccgcc   1540080
ttggcatagg ccagagcaag aacatgattg ggggtattac ctgaaaaatc aagaccagca   1540140
aattccttcc acatagcttg ggttttctgg ggataggaaa gggaatcagg cagattttcc   1540200
acaaatttct ccatctcagc acctttctct gtgtataagt cagcaatttt ctgataatct   1540260
cgaacttcct ctgtcccaaa aactagacta tcaatgccca agcgatccaa gatatccata   1540320
gctccttgac caaagaaatc agctgcctga acactgacta aaaagggcaa ttccactacc   1540380
aagtctgcgc cattttccag cgccatctgg gtccttgtcc acttatccac aatagcaggc   1540440
tctccacgct gcatgaaatt ccctgacatg gcaacaattt tcagtccctc tgcctgatcc   1540500
agcaggtatt tatggccatt atgaaaagga ttgaactccg cgataatacc tgttatggtc   1540560
atgctaatct cctacttctg cgccacaaaa aaccaacggg tgctagtttc tgttggctcc   1540620
ttatcctcaa agtctgcata gagtttgaag gacttaaatc cagcctgttc cagcaagata   1540680
tcataggtca agatctcata ggtcctctcc tcatgtactt catcgtggcg actaaaggaa   1540740
ccgtcagcct ccttgataaa gaaagtcagc tcatgcacga tggagtgagg aacttcgtcc   1540800
tcatatgtat cccaaagcat ggcaaaatct tccgcatttt catggtagga atagccaggg   1540860
aatacttcat ctgtctggta ggtcgagtgc acgtcaaaga tgaaaactcc ctcttcattc   1540920
agcgcattgt acacgtcctt aaagacgtcc cctacttcca cctcatcctg catatagcag   1540980
atagagtccg aataacacgt gacaaaatcg tatttccctg ccttggacaa attcagcata   1541040
ttaccttcta taaaagcaat cttttgcttg gctgaagttg ctctcttctc cgcaatcttc   1541100
aacatatccg cactcaagtc aagtccagtc acatcaaaac cagcctgaga gaagcgcact   1541160
gattgaattc ctgtcccaca agccaattcc aagagtttct ttctctcctt ggtcttaggc   1541220
aaatgacgca gagaaaaatt cgtccatttg tcgtataaac tatcgtccat gaccgcatca   1541280
tagaccgccg caaaggtttc ataagtcgcc ataatcatga tactaagagc tccatggtaa   1541340
acaccactag ccctttacct ttctatcaat ttttctaaaa taagcaaaga aacccagttg   1541400
actacaactg agttcatctt ctaagcaaga gcttctgaaa tatctactga attcgcctca   1541460
tgccatagct tctctagatt ataatgggca cgcatttctt ctgaaaagat atgcacgaca   1541520
acagcaccga ggtccagtaa gacccagcct ccagctgcat cgccttcgac atggctacct   1541580
ttaaagcctg cttgagctac tttttcacgg atattagctg cgatagcgtc caactgacgg   1541640
ctattcattg agctagtgat gaccaagtag tccgtcacac tagtcaaatc ttgtacatca   1541700
agtgcgagga tatcctccgc acgtttctca tcagccgctt tcacgactag ttctagtaat   1541760
tctttttcgt tcatttaatc ctctttttag aaaatatgtt tgtaatctag aacatctgca   1541820
aagcgctcct cccaaatgtc ctcataaaat tcattaatcg tttctgctgg aatgtcatcc   1541880
ccatcaaagg ttgtgacagc accttctgga acaataagct gatagccata ttcaaaggca   1541940
accttgacag aggtatccac acaatattct gtctgcatac cacataaaac taatttttca   1542000
atcccctgct tatccaagta ttcttttaag ccagtttctt tgaaaatact gttatacttc   1542060
ttctgaaaga ccttttcagc aggttttcga tttaaaagcg cagataactg ccaatcttct   1542120
gatgtttgag cttcagagtt ctcaatatgt tgaacataga taatttcaat attcttgctt   1542180
ctagcctggt tttgtaaata agaaattttt tccaatagac tttttgtctg gaacccagtt   1542240
tctactaaaa cattctgaac atcaatgatt ataaaagccg tcttcattta gtcctctttc   1542300
aaatagtgca caaaggcgtt ataggtttca agggtttggg gatagatggg gaatccctga   1542360
tgagctagat actccacggt acgagctgtt tcgtaggcca ccgccttatt gagcgataga   1542420
cttgcaatct cacgcgccac atctactcca ggaaaggctc gattgtgctc gatatagtct   1542480
gcgacgtaga tgaccttatc taggtctgtc atttgaccag ctccgactgt atgaatttca   1542540
atggctcgca gaatttcaga atcatgcaaa tccaaatctt cctgaatttt gtaaattccg   1542600
accataccat gccagacatt attgccccag tttttgaggt cagggtctag ctggtaacgg   1542660
tcaatcaaga ctagaaattc ctgatctgac aactttttag catagtcatg aagaagacct   1542720
gctagacttg ctttctcaac atctacacca aagcgctgag ctaattccat agcggcacgc   1542780
tccacaccta gacaatgggt tagacgtttc tcaggtagaa gctctgccat tttttccaac   1542840
aaggcctcac gggagcagtt gatatagtct tgataggaca tcagtagagc ccttccttct   1542900
cgatgtagtc tagcactggc tgaggtagga gaaagttggg tttccgacct tgggcaagga   1542960
agtcccgcac catgctggac gagatatcca tgagcggtac gtccacccag ataactggat   1543020
aggaagtccc taccttgtag cgtggacgct gaacccccac aaactgaacc atgtcaacca   1543080
gttcatcaat tcggtaccac ttaggcagat agtcaaccat gtcggcaccg atgataaagt   1543140
aataatccgt atctggattc ttctctgtca aaatcttcat ggtgtcgtag gtgtaggaaa   1543200
tacccttgcg ctccaactca atggtttcaa tgactaggcc gtcaattccc tcaattgcca   1543260
actcaagcat cttgagacga tggtgttcag ggatggtttc ctttttatca acgtgaggag   1543320
gttggtattc aggcatgaga agaacttgat ccagtcccaa ctgttgccgt acttgatccg   1543380
caacaatgag atgggcattg tgaacagggt taaaattccc ccctaaaatc ccaacttgtt   1543440
tgcgtttttt ctccttgatt tctggctcca actctacctt ggtaaaggga gtcaatagtt   1543500
cgattgtcat aggctagtcc cctttatttc tctataaaaa cagttatttg gagtttcggt   1543560
cttagatttc tttgactttc ttagaaatct tgcgattttc tttcttgcta gattgtttaa   1543620
acaaaatcaa gatgcgtcct attttttgga ctgtatccac accgatttct tcttccaaaa   1543680
tttcagctac ttcgtggatg ttttcatctg tgttttgtaa gagagtaacc ttgattaatt   1543740
cacgcgcatc aagagcttga cggacgctgg ttttgatttg gtcgttgagt ccatttttcc   1543800
cgatttggat gataggtttg agggtgtgtg cctggctgtt gaggaaggca cgttgttttg   1543860
atgttaatga cataattttc ttccttgttt tttgatagtt attttaggtg gtgagggacg   1543920
gtcggaacta attttccaaa gatttcatct ttgaaaaatg gatttcctga cctcacaatt   1543980
gagtcttggt ctcaattgtg ccccttgcca atctacagat tggcaatcac accacagcaa   1544040
taactatcgc tatatgagct cactttgttc gctcagcgat tttgttttaa ataattgctt   1544100
ttcgtgtgac gacggcgacg ccttctggtg cccagacggc gacttttgct atgcctgtta   1544160
cacgaatcca tcctaggcct gagataacta ggtctgtctt atctttaatg gtaaagacat   1544220
gctggactag ccttgggaaa tcttcttttt ccttgctatt tggtggtgtc agaagagttc   1544280
ccaggtgctt atcgtagaaa gcactagctc cttcaagctt gctacgatgg agtttgagtt   1544340
cattatcaaa gaaagcagta aatccttgct tttctcctgc tataaagtca aagcgtccca   1544400
aaccacctaa aaatagggtt tgctcaggat taagctgata ggtcttaggc ttgatttcct   1544460
ttttaggact gacatacttg aggtttttgg ccgtcaagta gtgagccatc tggtggcggt   1544520
ggataattcc cggcgtatcg taaatataag atccgtcgtc aagcggaatc tctattttgt   1544580
ccaaggttgt ccctgggaag cgtgaagtag tgatgacatt ctgatcaccc gtgatttctt   1544640
ggataatagc attgattaga gttgattttc caacgttggt cacaccgacc acatagacat   1544700
cgcggccctt acggtagtgt tcaatcttgt caatgacttc cttaatggca tgtttatttt   1544760
gtgctgaagt taggaccaca tcgactggac gaagaccttc ttcatgggca cgtttcatga   1544820
gccactggct aatcttacca gacttaactg acttaggaag gatatctttt ttatttccta   1544880
ccaagaggac atcattgccc gagacgaaac gtggtaaacc tgggatgaca gatccattaa   1544940
aatcaaagat atcaataaca ttgaccacta aagcatcact gtctcccacc tcgtgcaaga   1545000
gcttgaggaa atcatcgttc gtcaactgga catctgtgat ttcattgtag tggcggagac   1545060
ggaaacagcg ttggcaatag acttcgccag tctccaaacc tttttcaagt gccgactggg   1545120
gggtaaaacc aagaccagct ttatctgtcg tctgaatggt tgctccacaa ccaatacaga   1545180
gaatttcttc catagttaaa ttcctttttt atatgtaatc ggtccgtact tttcagtgat   1545240
ttttctcata acacgacgct cacgagttcg gttaatctgc gttttgattg agtcatgttg   1545300
gaccaagggt ttgactaaaa ttgaccgaat ccctgcacgg tgggctgctc gtatatctgt   1545360
catgagttgg tcaccaacca tgaccacttc ctttttgtca tagtggaatt ccttcatagc   1545420
acggtcaata ccaaatgtga agggcttcaa ggcccagtaa acgtaatcaa tcccaaattt   1545480
ctcaactgct cgttgaacgc gttttttggt gttatttgac actacgataa tgccaatacc   1545540
cgcgtcccga aggtcatgta gccattgctt catctctggc gttccatcag ggttgttcca   1545600
agcaatgagg gtattatcca aatcgaccaa aacagccttt attccctgcg cctgcaggct   1545660
tgggactgtc agatcataga ctgcttccac agcaaaatct ggtatataat tttcaatcgc   1545720
cattctggct ccttttctta actttttttc gcaattttcc ttagtaacaa ggataaaaca   1545780
atccacaaac ctgcactagc caaactgata tagagccaag catggggctc atctgttaaa   1545840
ggtaagggaa cattcattcc gaaaaagcct gtcacgactg ccaaaacagc tagcaagact   1545900
gaaatgatag tcaaggttgt caaattgtca ttcagattat tgtttagaat attgttgtaa   1545960
gaggctgaaa gctgctgtaa aatctgagag attaggtctg tcatggatac cagctgatga   1546020
gcctcaatca tggcatcatc aaactgttct ctctcaatct catcaaaact acgatacaag   1546080
gcatgacctt gaatatgctc taacaaaatc cgattttgtt tggcagctgc cgtcagataa   1546140
accataccag tctccaaatc agacaggaca aagaggtttt tcttggtagt tcgctggcgc   1546200
aagaggtcat tgacctcatc cctactcttg tccatctgct caatgacagg atagtaggca   1546260
ttgctgatga tttccagact ggcaaagaga aacttataaa tcgaaagcgt gtcatggttc   1546320
tccagataac gagtcatctg ttcaatgaca taggcgttct tggtattact aatggtaatc   1546380
aggcgacgat gctcgacaat aaaggtcatg ggaaaagtct catagtaggc cttgtccttt   1546440
tttacgtcta agacattata gataaaggta accgtctcac tttcacggtg gtagtccatg   1546500
tgggcgcgct cgtttctatc cagtgcgtat tcaatggttt ccttgtccaa accgtaaatt   1546560
tcagaaaggt cttctagttt attcaacttt cctaggtcta ggtctatcca ggtacaacca   1546620
ttgcccaact gcttttctaa aaccatcttt tctccttatt aaactccctc tattgtacca   1546680
caaattactt aaaataacag gtctagtctg tgcgtgagaa attgctaaca actgtgatat   1546740
ttcggttagg gacaaagtga agggcttgct cctcgctacg aagctgtgtc gtacgaattc   1546800
ccacactgac aaccttaccc gatacagtaa tcggtccatt tgtcagaacg acctcatctc   1546860
ccacatccag ttgacgttca aagaggatga aaaagccatt gatgacatca gacagaaagc   1546920
cttgggctcc cataccaatc gctaccccag caataccagc tccagccagc aaactagaaa   1546980
ctggcaaacc taaaatcgac aaaatgcagt agagtaaaaa gaaatatagc gtataattaa   1547040
acacattttc tagtaaacgt gagatggttt tttggcgtcc aacatcatga cgagacattt   1547100
ttagagaagg tttgacaatt ctctgcacca tggtatgaag cattttttta gcaatataaa   1547160
atacaattaa aagcagtaaa agagaaatga ccttggttag aatattctcg ataatggttg   1547220
tcacatctag cttttcaata taagcctgaa taaatttttg catataaaac tcctttattt   1547280
cattatacca tattttcatc agtctcattc tccataaata ttcaaaaaat agacagaaaa   1547340
ttcttgattt tgtctatcat ttatactata atcataatca ctacacaaaa aggagattat   1547400
tatgaaaaga atcattcatg cttggaataa ggcaagcctt gtcaagcgta tcttgattgg   1547460
tatgctttgt ggggaatcct aggactgacc cttcctaatc tctcagggat tgggctactc   1547520
gaggatttat tcgttggagg tctaaaagct gttgctccta tcctagtctt tgctctcgtt   1547580
gccaatgccc tttcccaaca tcaaaaggga caagatagca atatgaaaac tgttgttttc   1547640
ttgtatatcc tatgataggg actttcgccg ctgctcttgt agctgtacta gcaaatttca   1547700
tcgtccctat tgaaattacc ccaaatagtg ccaatactga aattgcacca ccagatggga   1547760
ttgggcaggt tctcagcaac ctcttgctca aactggttga caacccagtc aacgccctgc   1547820
ttactgctaa ctatattaga atcttatctt gggcagtcat ttttggaatc gctatgagag   1547880
aagccagtaa aaatagtcaa gaattgctaa aaactatcgc tgacgtgact tctaaaattg   1547940
tcgaatggat catcaatctg gctccatttg gaatccttgg tcttgttttt aaaaccattt   1548000
ctgacaaggg agtcggaagc cttgccaact acggtatttt attggttcta ttagtaacga   1548060
ctatgctttt tgttgcccct gtggtcaacc ctttgattgc cttcttcttt atgagacgca   1548120
atccttaccc tctagtttgg aactgcctcc gtgtcagcgg tgtgacagcc tttttcactc   1548180
gtagttctgc gactaacatt cctgtcaaca tgaaactctg ccatgacctt ggactcaacc   1548240
cagataccta ttctgtttct atcccactcg gttctactat caatatggct ggagtagcga   1548300
ttaccattaa ccttttgacc cttgctgcag ttaacactct tggaattcct gttgactttg   1548360
ccacagcctt tgtcctcagt gtggtagcag ctatctcatc ctgtgatgct tcaggtattg   1548420
ccggaggttc cctccttctt atcccagttg cttgtagcct tttcggtatt tctaacgata   1548480
ttgccataca aattgttggg gttggttttg tgattggtgt catccaagac tcatgtgaaa   1548540
cagcccttaa ctcttctaca gatgtcctct ttaccgccgt tgccgaatac gcagcaaccc   1548600
gtaaaaaata actcatcaag gcaagcctgc tcatgtcttg tcttttacgc ttttattcta   1548660
acttattagg aaattcttat gtctattagc caacgtacga ccaagctcat cttagctacc   1548720
tgtcttgcct gcctgcttgc ttattttctc aatctttcgt cagcagtttc ggctggaatt   1548780
atcgctctct tgagcctatc tgatacgcgt agaagtactt taaaactggc tcgcaatcgt   1548840
cttttttcta tgcttctagc tctggctatc ggtgttctag cttttcactt gagcggattt   1548900
catatctgga gtctcggcct ctatctggcc ttctacgttc ctttagccta caagatgggc   1548960
tgggaaattg gcatcacacc aagcactgtt ttggttagcc atctcttggt tcaagagtca   1549020
acctctccag accttctagt caatgaattc cttctctttg ctattggtac aggatttgcc   1549080
ttgcttgtta atctctatat gccttcacga gaagaggaaa tccagcacta ccacacgctg   1549140
gtggaagaaa agttaaaaga tatcctccag cgcttcaaat actatttatc cagaggagac   1549200
ggacgcaacc gagcacagct ggtagcagaa ttagacacgc ttttgaaaga agccctcaga   1549260
ctggtctatt tggatcactc tgaccacctc tttcaccaga cagactacca tatccactac   1549320
tttgagatga gacagcgaca aagtcgtatc ctgagaaaca tggcccaaca gattaacact   1549380
tgtcaccttg ccgccagtga aagcctgatc ttagcgcaac tcttttcaaa aattgcaggt   1549440
caactgagcc agaccaatcc tgcttctgat ttgctagatg aaattgaacg ttatctggaa   1549500
gtcttccgga accgcagtct gcccaagaca agagaagaat ttgaaacccg cgccaccctt   1549560
cttcaactcc tacgtgaagc caaaaccttc atccaagtaa aagttgattt ttaccaaaaa   1549620
tatagacagt aatactcttc aaaccacgtc agcgtcgcct tgctgtatat atgttactga   1549680
cttcgtcagt tctatccaca acctcaaaac ggtgttttga gctgacttcg tcagttctat   1549740
ccacaacctc aaaacggtgt tttgagctga cttcgtcagt tctatccaca acctcaaaac   1549800
ggtgttttga gctgacttcg tcagttctat ccacaacctc aaaacggtgt tttgagctga   1549860
cttcgtcagt tatatctaca acctcaaaac ggtgttttga gctgacttcg tcagttatat   1549920
ctacaacctc aaaacggtgt tttgagcagc ctgcggctag cttcctagtt tgctctttga   1549980
ttttcattga gtataaaaaa gaaaacttca gaccaatcca caaaaggtga atatctgaag   1550040
ttttctttta tttataagta atcaccataa aggttaatag tagaataaat aaagccaaac   1550100
tcaccaataa agtgagcacc ttgaccaagg tgttgctctg ccagtagctt ggtttaccaa   1550160
tattactagt ggcatccatg gaaaatagtt gattttgacg gggttgtata gttaccaata   1550220
caatcaaagc aagagatagg ataatagcta aaacaattag tatttcaatc atagatctac   1550280
ctcaaaattc ccagcaaagt aaagagcaaa ccaatcagaa tcatcaaacc cagtaaaagt   1550340
gaaaaagtct tactaatctt ttcccctcgg gtttcttttt ccttcttgat gggtttttgt   1550400
ttcaactctt ccatgcggcc ttcaacgtct ttgtaaaata aatcttcctc tgacatgtta   1550460
gcctcctaaa acagtttgca tggtttcctg atatctcacc aagtcaacat aatttgcatg   1550520
ttggccttgt ttgccaagtg cctgacgcat ttgatcaaca tctgaaaggg ccaatttaat   1550580
ggtctcaacc aaagcagcaa cttcactact ttcaaataga tggtctggag cgatataaag   1550640
tctattgtgc accgtctgat taaagccaag aatcaagaga ttgtgctcaa aggcctgacg   1550700
cactgcctgt agcaactcat tactgtggtt tatatccaag taaatatccg acagttgata   1550760
cagctcctga atcttctgtg gactagcgtt ctggtaaagg gccacattag gatagcaaag   1550820
catgtctaag agcttagaag acatctctgt caccgctgca atacggaaag tgacatcagg   1550880
caaggctcct gcgattgctt ctacttgctc aatctgatct gaattggtca agattaaggc   1550940
atctcgtctt aggaaattat cacgtttgaa ctggtaatga taacccaagt gcacaaactg   1551000
atcatggtat ttctcgtcag ttaactctaa agcgcgctca taagtcgcct tatttggaat   1551060
gatgatcttc ttagtacgca cattatcact ttccaaaatc aactgcatat tacctggaat   1551120
ggcatcatag agaggttcct gccataccaa gacatccgag ccagatttat ctggatgatg   1551180
gaaggaaacc aagaaaggag tcgctagagt attaaagata agctgactgg tatctatttc   1551240
caaatcttgc aaaaagaagg tgataaattc aactttattt gcaaagtaac gcatggactg   1551300
acctggcaaa gtcaataaga tatcacccgt cacatggttt tccagtaaaa cttgttgacc   1551360
attgacatct tggtaaactg tcataatcgg ctcgctatct gcgctataag tcgttgtagc   1551420
aaaacaagct ccgaagcgat tgtagtggtc aacctgacgt actcgacctt ctaggtcttt   1551480
ccagtctacc tgtttaacca agcgagcctg cattccatca gcataatgaa tgacagccct   1551540
ctcctgcgtc acatcttcaa tacaagcaga ctgattatct cctaaaattt cccaaaaatc   1551600
tgaaacggga acttgattaa aatagagagg ttttccatcc tcgtaaccta gataataggt   1551660
aaaaggagaa agcagaccat caggcagaaa accatctgca tcgatgacca ctccaagttg   1551720
agaaagacca gtagcgccta gactttcatg taaatctcga ctttcttgac tgtaactatc   1551780
ataaagttca atcatggagc acctcctcta ctgttttctt ccacttttct aaaatttctt   1551840
tggtcaagaa gccttctgca atttggtaag aataggcacg catagcttcc aaacgatttt   1551900
cttgatacaa ttgacaaatc ttagcggcat aagcttgctt gatttggtct tctacatggt   1551960
cagatgaact tggaatcaaa taaccatttt gcccatcctc tataaaggtc tgattaccat   1552020
aaggcacatc aaaaccaatt agaggtagac ctgaaccaat agcttccatc aaggtcagac   1552080
caaatccttc gctggtagaa gccgttaagt agacctcata ctggctataa atctgcgaaa   1552140
gttccgcatg ccccttgagt tggatatagt cctctgcctg atgatttgca ataatttctc   1552200
taagcagaga atcttctcca ccactaccat agatatcaaa ggttagttcc ggtaactcct   1552260
tatgagcttc aatcacagct ttcacaagcc aatcaatgtg cttttctttg gcaagacgtg   1552320
aagccgtaat caatgaaaat ggtttgcgcc cttgacttga atctgtcaag gaatcaatac   1552380
tgcctacagg aatggtaaca atctttggct gatgctgagt atatttggca aattgctctt   1552440
gtagaacttc attttgtcta tcagtagaca cgataaagaa gtcaacctta tctgcattgg   1552500
taaactgata gtcataatag ttattccaaa ggatatagtc ctcatttgta gcattttcac   1552560
tataatgctc cgcatgaaca actaccgcta gatgtgctgt ctgtgcttcc tcaaacacaa   1552620
cctgtccaat acctgtctcc ctatcgagaa tgaccaaatc agacttattc aaattcaaag   1552680
atttcataaa ggcacgcaca aaagcttgct ttccatagaa aatcttatcc ttgaaatgat   1552740
aaacttcttc cttcccttga ttcatcaaga tatcatagac tggagtcccg tcttcattat   1552800
aaaaagttcg ttggtataag actgcaacat tgtccttggg agcaaaatac tcgctacaat   1552860
aacgcgtata agaaaagtaa tccttccgaa tcaggtttcc cttaaaaaca tactcggcat   1552920
gttgaaccaa gtccttgttc tcatcaacca aataacaggt tacaaactta tcttggtcaa   1552980
aaaagaatac acgtaaaacc ttgccatttt tttctctgtg actttcttca ccaccaaagt   1553040
aagccaagac atcatccact gtcacgctag taggtgcaat tttgatatct gtgaaatgat   1553100
tataaagcca gataacctga ttatcatcaa aaccaatatt ggctgttaag tgctgaatat   1553160
tatcggctaa aatcatatct gtaaagataa acttagagga cagatttaat ttccgaaaaa   1553220
caccagcacg ataggcttga gcgtattcaa caccgctact agcccaacca attcctaaat   1553280
ttatattgta aattgtcata ttttctcctt ttatggaaaa tgagtcacga tttcaccttt   1553340
tggagtgacc tcaaccagcc ccatcaggag attacgcacc atatccgcat gaatctgttc   1553400
tttcatagct tcaaagcccg cgtaggcttc ttgatagtac tctacgattg gatttttctg   1553460
actagcagat tgaccaccga tagccatgga tagctgttgt agatagtcta cctgctctac   1553520
ccagttgtca tcaatggctt taagcagtga aagtcgtaaa aactgttcat ataagtcatg   1553580
ttgattaagt aattctttct tttcagaaag ttctttatca atcacctgct tcataaagct   1553640
acgaactgca gttttgtcag ttacatctat ataatctgga acctctttaa catgaaaact   1553700
aatattggtc acaataaagt gaaacaataa ttcacgacta gcatagtgat cagccgctac   1553760
ctcttctgta tatctctcaa tgatatccac aacaacatcc tctaagtcac gagaaccatc   1553820
tattagacga tttctctctt tatagactat atcccgttgt atattcatac tttcagcata   1553880
ctccagagtc tgacgacgtg ctgaacgtcc agcactatca ctggcatgct gagccttttc   1553940
gactagtttc cggtatttac gacctttcaa tacttccggt tgagtcatat cttgaacctg   1554000
atagtctttg tactttttat gcacccaaga tggaccaaat ttcttgataa catcatcctc   1554060
taaggataca aaaaatttac tcataccagg atctccctga cgaccagaac ggccacgaat   1554120
ttgtaggtcg atccgctgac tttccatccg ctcagtccca ataacaatca agcccccaag   1554180
ctctgcgact cctttaccaa gcttgatatc cgtaccacgt cctgccatag aggtagccac   1554240
tgtcacagcc cccatctgac ctgactcgga gataatctga gcctcacgcg ccgcattatt   1554300
agcatttagg acattatggg caatcccttc acgaaacaag agagacgaat agagttgaga   1554360
catttcaact gagcctacaa aaacgagtaa aggatttccc ttagcatggt attgcttgat   1554420
gtactccaag gatgcataca ctttttcagg taaagtgata tatagattat ctggatagtc   1554480
aatccgttgt ctcggacgat tggttggaat gcgtactaca gacatattgt aagtttcaat   1554540
aaactctttt tccgcgacct tacctgtccc tgtcatacca gatatcttat taaacatctt   1554600
aaaaagactc tgataggtga tcgaggccat agcccgcgtc tcaggagata atttgacatg   1554660
ttccttggct tcaatagcct gatggagacc tccttgaagt ttagtcattt ccattagacg   1554720
ccctgttccc ttatcaacca gtaccatctc atttccacga atgatatagt ccttatcttt   1554780
agtaaagagc ttatgagctc gaatcgcata aaccaaatga cgagcaaaag acgcatgctc   1554840
ttccttgtat aaattatcaa tccctaggaa attctcagca gacttggccc ccttagtagt   1554900
gagccaaacc tcctctttct cctctttaaa gatataatcc tctccttcga ccaaggttgt   1554960
tacaagtgta tcaatgatcg catagtaatt agactgaaca cgaggagaac ccgcaataat   1555020
cagaggagtt tgtgcactat caagcaagat atcatcaatt tcatcaataa tcacatagtt   1555080
aaacggtcgt aaaaacttac cttcttcatt cgaggctagg ttatcattta gataatcaaa   1555140
acctaaatta ctattggttg tgtagatgat atccgaagca tagataagct tcttttcttc   1555200
agctttcatc tccttctttg gatcttccgt aaatggtaca ccaatggtca atcctagaaa   1555260
acgataaact tgacccattt cctcggcatc acgctttgat aaatactcat taggagtcac   1555320
aaccatcact ccttctcctg aaaaagcgtt caaatagaca ggcatggtag ctgtcaaggt   1555380
cttaccttcc cccgtattca tctcagcaac atttccatag tgcatgacaa tagctcccat   1555440
gacttgaaca tcataaggaa acatccctaa aatccgctta tctgcttcac gcaccacagc   1555500
aaaagcttca accaaaatat cgtctagact ttctccctcg gaaagacgct gacgaaactc   1555560
tactgtttta gctactaatt cttgatccga aagagaggac atcttgcctt tcagggcatt   1555620
aatctgcttt aaaatctttt tcactttcct aagctggaaa tcttgaccta aacgtctaaa   1555680
cacttctgat ctccttgata gaaaaatgat aaaaagttaa ggactcaaat ccagcactta   1555740
aaagagaaac tcgataagta taactatctt ctggataagt aaatatgaaa tctttcactt   1555800
tttctacctt tttttctaaa atatcaccat agcggtcaaa aaaagttatc ttggtataaa   1555860
ctccattttc aggctgacag tcaaaaacca gtgatagttg atactcctgc tttcttttta   1555920
ataagggaag ctgaggttgg gttcgtgcag cctggtaatt gacactagaa aaccaagtct   1555980
ttagaatctc accagatggc aatagaggat tatacagacg aacacttttg tcagggtaat   1556040
aagatacagt tgttccatac atataagtcc caccaacttc tccccaatga atagactgtc   1556100
tctgtgtaat aatcatcttt tctcccttcc aaaaccagtc tctaagacca ttctataaaa   1556160
gtgcaaaaac caagaaatat tggtatctgt atcatcattg tgtcgtccag cagttccttt   1556220
agataaaatc ttcgcacctg tattacacag ataagacact aattgttcat aggcttgtgg   1556280
atccatttct tcatctttca tataggataa accaaaggtt gtctttgaaa aatttgcttg   1556340
tttaaaaatt ttccaaaaac gctgatccaa ctccgtcata tcttgagaac ttgtcccacc   1556400
tgtatgatga attaaacaat caaaagctaa gttagagaca cccggtgcgt ccaaacgtcc   1556460
acgactagct atagttccta aattagccaa gggcttacca actatgatgg catggggttc   1556520
aaaagaagca ccataataga gagccggaaa cgttcccata gaaagacctg ataaaatcaa   1556580
atccttatga tcaaagccta aataatcaag atagtgagtg atcgtatcct ttacttttcc   1556640
ctctagctca tccgttccga gataaaaagc tcccccctct aaacgtggat cagaaaataa   1556700
aatgaaggga catccaagag ttttcatcat aaagtaaccc tcgaatcctt ctgcaggtcg   1556760
ataacctgca aaatagacag tcaaaggcgg tttaaaatca cctggatgga agaaatagtt   1556820
tatttcatca cgcttggaat catgtaggat atttccacca agtacaaact taccaaattg   1556880
ttttcgactc catcgttggt gaagattacc tagtttgata gttccacgac ctcttgcttc   1556940
aacagatatc gagagaaagt agtctccgtc tcgactatcc ataaaaagtg cttgctccaa   1557000
gtctttttca gatactatta cttcttcaaa gaaatcatca acagacccac tccacatttt   1557060
acggattact aaacgaaagt cacaattgcc ttccttctca tattcaagcc acaactcaat   1557120
agggagtgtt ttttgcacca taatattata agcccaatag gcaagctggg caaaatcttg   1557180
cccaaactca ccttccaaac tgacataatc caatccttga taagaaatag ctcctgtaaa   1557240
atttggattg acttgtatcg tcggaggaaa gagtttatca ccatacccac cgccaaaaag   1557300
agatttactt aaatcattga ttagttgttg gggacttaaa aaatcaattg cttgtgcaca   1557360
tcgttttttt agaaaatcca caacctctct atcatttatt tgtagattct ggttataaaa   1557420
taaagtataa ggttcaaaat attttacata ggaaaataag tctctggaat actgaccatc   1557480
ttctattaaa actgcatgaa aacggttaat atcctctttt tcaattattt cacgaagggc   1557540
ttttgatgag tttgggtaaa aataatacca actcatattt tcaggtatgt catagtgatt   1557600
ttcccaattg gcaagtccta tctgtaaaat attaagttcc tttgacattt ttaacctcct   1557660
ctatccattt ctctaatttt ccaagaaatt gttgtcctgt gtgctcctta atcttatcaa   1557720
ttgaatatat caaggactca ttccactcct tcaacctatc tgtgtaataa tgtgcagcct   1557780
tagaaaattc tgtaacatct gctaacaaat aaccattttt taaatgttca acatagacgg   1557840
tttcaactag gttgatttga ggaattcctg cactaatccc agcaatctgt gtgtagagat   1557900
gaggatgtct atttaaatcc acaatcaaac ggacaaattc tagtgttttt atcaaatcta   1557960
actcatcatt caagttaaca aactgtaagc gtaagtcctg gtgttgattt tcttccagag   1558020
gattttctgc atcaccataa tcaatcgcct ttcccagatt ttcggattga atgttttctt   1558080
ggatgaaaga ctcaacaatc ccttcaacct cattcatttg ctcctgacta gcagcaaagg   1558140
ctccaaaaat cacctcagta tccttatttt cagcgacaaa ggacaagact tgaagcagag   1558200
cttgattatc aatcccctgc tcaaaatcca gttgaaaata aatgatggat tctttcttag   1558260
tttggcttcg tcccaatcgt aatcgggtgt caaaagatga taaatgataa cattgatgca   1558320
ttcgttcagg atacaactcc tgcaacaatc gtaaactatc ctctctatcc accaaaatca   1558380
aatccgattt ttcaaaagtt acatctaaat ccctaaaggt atcttgagga ttacgtccaa   1558440
tgaacagact caacagttta ggattagtac taggtaaacg atctagtacc aactggtcat   1558500
gatgagaatg agaaggaagc ataaaaatat cctgatcctt cacatacgtt tgcagataat   1558560
tctcaaaaaa ttctgccacc agatctccca tattttgata ggtaagcatt ttaaagcgat   1558620
aacccaaaat tggattgact tctacctgtc ctccttcttt taaacgctct ctgaattgcc   1558680
actctccctt gaggttcaga tattcttgat aggctgcttg cccatcttca aaaaagataa   1558740
tgctcgatac aaacccacga tcatccacga tatggtgcat atgtatttga ccatttggtt   1558800
caaaatactg tatatcactg atgaagcctt caactccatg ttcaacctta gcaaatttct   1558860
tcccattttt ttgaacgata atcgtaaagg gactataaat aaattcacag tcatcatccc   1558920
actcaatatc tctaatgctt aaaacttggg tatggagatt atgaaaatct tgcataacat   1558980
caaaaacgga ataagtatcc atttctaaca caccatgtct atataaaaaa taacgtagat   1559040
gaggctggta agctaatact aatagacgag aatctatatc ttgctcttga aagagccgaa   1559100
tctggtgaaa ggtatcatca aactctagac gaaaatgaga aaaataccat ggagtgatat   1559160
ctgcatgcca tgttctttct gacccatacc aagctggaat aaaataatac ataaaagtct   1559220
cctaaatcaa aggtctatag gtctcattta gccttaaagc cttgacctcg tctctaatcg   1559280
taaaaatcat gcccccgaac atcataaata agcctggaat cattgccaat cgtaataact   1559340
tttcatcaaa caaaacaaaa agcatgggac cacctgccat aatcacatta aagagaccac   1559400
ctatgactga gaaacgaagg accaatcgat taataaatcg actagtatcc gcacctggat   1559460
aaataccata aatgtattct ccagattttt tcatacggtc tgcaatctct tctccattca   1559520
tcgtaacaaa agcaaaaatg atactaaata aaaataagac cgaaatataa acatagaccc   1559580
acaaaggctt tccaaccata aattcctttg ataaagccgc taaccctgaa tgattaggga   1559640
aaataaatcc caacaagatg aacaaataag ctggtacact aagaaaactc atcacataca   1559700
tataaggcat cccacctgca ggattcaaca tgatttcgag ataagaatag cgtttaaatc   1559760
gattgtgtaa gccaatttta ttaacaggaa ccaaatagcg agctcgatac ataagggcaa   1559820
gtaaataaga aaagacaagg gttaataaag caagtaacac aataatccct gttggaatgt   1559880
gtactgtctg aaatgtttcc aaaacatcct gaggaatatt taaaaccata ctggatagga   1559940
ggattacaat agaacctcca atccccatac tcgcatttaa atctgacaac caaacaagaa   1560000
aaaatgttcc tgctatcagc aatattgtat tcattagaac aaccaatatt gcagaatagg   1560060
aggattgtac tggcagtctc aagctaactg ccaaggattg aatcacagca attagcaagg   1560120
tcaggtacat tttacggcga tcttgtattt ctatagacgt agatgttaaa cccaaccgtt   1560180
tagaaaaaga aaacatctgc cataaaatca tggcggacat ccaaggggat aatccaacag   1560240
aaaaaattga taaacttctt agattcccac ctgttagggc ggctgagaag gctagatagg   1560300
ctgttgaacc tcctaaaaaa tctttagtat ttaggtcaac aaaagggaga ataatacgac   1560360
ttcccaatac atagataaac agtagaaatg aggtaaatag tccttttttt actgctattg   1560420
acgaataaat cttagtcata aaacactccc ctcaccttca ttgtttgtga tatggtaaat   1560480
aacaattctt ttatttcaac ttttaccatt tctttgttct gcatcaaaaa acaactttaa   1560540
tctgaaacaa atatctttat attcctcagt atctgttaat tgatggtatt ctaaagtttg   1560600
cttataatct tttaaaagat tgacaaatcg aatacgcaga acggagacat ccaaaccagc   1560660
caagacacaa tccgatattt tcttagaaaa cacttcaaca atatctcttg cccaggaaag   1560720
atcaaattcc gttctcatga tgcttcctga acgtcttcta tacagataga gattatcgtt   1560780
tataaagacg attttagagg ctaaaagata aaagcgatgc atagttgctt catcatcaaa   1560840
gcggcgacca tttgaaaagt gaacttcatt gaataattct tttttaatca acttaaatgt   1560900
cggcaatata aaggccgagc tattgaattt ccaatctcct gcttgacggt tcataatttc   1560960
ttgtatagct aattcttcga cgcaaaaatc ttgccctgtt acataaaaat aaaaattccc   1561020
gtcactttcg tcataattat agtaattccc tataacaaca tctgcatcct tttcttggac   1561080
ttgctgataa agagtttcaa tcatattttc ttttacgata tcatctgaat caacaatcgt   1561140
gatgtactct cccttagcta cactaatccc catattttta gcttgtgctg cccccccctt   1561200
attttcttga tgcaatactc gcacacgatt atcttgcatc ataaaagcat cacaaatttc   1561260
cccagaatta tccgtagaac cgtcatcaac taaaataatt tctatatttt gataggtttg   1561320
cttcagaata tgctcgacac actccactaa atattttccc gtattgtata tcggtaccac   1561380
aacactaatt aattcactca ttactctatc tctatattct tcattctatc cactaaatca   1561440
tctggtctct ccacagaaaa aataccgtca tagagtccat catccatact tttacgtgtg   1561500
atatcaaaag cgaagatttt cttgccactt tcttgtgccc ttgtaactac attaaaaacc   1561560
tctccacctg tattaatatc taaataaact atagaatcgt ccaatagcca atcaattcta   1561620
ctatgtaata cattttgata tactgttaca ttcgtatact gtgatagaga ggtcagctcc   1561680
tcagaacaat cacacggtgc agccaaatga aaatgccaat caggtaaccg ttgtactaaa   1561740
tactctaaat gttttatatc tgcactccat gtcacaagca tcacttgttt tttagactga   1561800
ttgcttcttt caaaataatt taaatcggaa cgttgaaaag caatctctga ccaatccaaa   1561860
tctctataaa cccaccataa ttcacgtagt ctagatatac tatatgtatt ccaaggttta   1561920
tcatgactag catagtgaac aattgtaggt ggattgtcat ctagacgttc acattcttga   1561980
gcaaggtgat aaatatcaat acccaccata taattatatg ttttatctaa ggctagccaa   1562040
ttatcctcaa aataaatatt taaaatactc tgatccccaa gatgaacaac ttgattctgc   1562100
tcggccgcta attccaataa actattgaca atagaatgtt ctttccactt tgcaacatcc   1562160
attagtaaca taccagtatt aaatccagat tttcgtcctt cataggcata gacatcatca   1562220
acagcaccaa ttgaatatcc tttgagatct atctcaaaca aagtagctag ttccccagtt   1562280
acaatgatat cggaatccag atacaatacc ctatcagatt caaccacttc tgtcgcaaaa   1562340
aatctaaagt aagaagcata atttatatga ggtcctgttt tatagctttc aaaaagttct   1562400
ttatcaatgt gtacactgcg aattgtagaa ttcacaactt ccatttttct ccccaataat   1562460
ttaaaccatt caggagctat atcactgttg agaatataaa aatcaacatc tctattgtga   1562520
tacaatacag actttatagt cgtctctaaa ggaataagat aggcattatc tgccgctaat   1562580
actattgatt ttctcatact gttctctacc tcatgtaaga tctgattgct gcaaccattt   1562640
ttttcggaat ggagcttgga tagatacctt catatgaaat ctcagaaaga ttttcagagc   1562700
aagtattgtc gaaagctatc attggttttt tgtacttaag cacaaactca tatgcatctt   1562760
ctaattttcg atcatgattc aaatccaaat acaaatctga agctattact atttgttcca   1562820
ataacattgg taaggaattt ggatatacgg taacattagg aaaacgcgtt aaagctagta   1562880
gttcatttgc catatttgta taagcaacaa tatgaaaatg aacttctggc aattgctccg   1562940
ccaaataatc gattttctcg acacaccaag aattcgttaa attaacacat tgcaacttaa   1563000
atatttgtga tttactaggg tacttcacac tctttgaaaa ccattcattt aaaataacag   1563060
accaatccat caaagagtat tcccaccaaa cttctcttag acgtccaaca gaaaattgat   1563120
tccaaggctt atcctgagaa atatagtgta aaattagtgg cagtggttcg agcggaatat   1563180
caaaaatgaa ttgatgttta aaggttgccg ccccataatc atatcctatt tgaaaattat   1563240
attgatcttc aagggaacta tattgatctt taaacaacat attcaaaatt gactggtctc   1563300
cttcttccac attctcatgt tctttttctg ttaagtcaat caatttttgt cgaatagttt   1563360
cagatcccca ttttttgttg ttaatcaaga gaacaccagc attgaagccg actcctgctc   1563420
caaagcaaga acgagctgct gccaaataat tttcacctaa gtctaattca aacaaatcgg   1563480
tcaaatcacc agtcacaatc aaatcactat ctagatagag aactttatct tctgttacaa   1563540
aatctggaat aaaatagcgt gcaaatgtca tatgattgat atgaggtaat ttattagacc   1563600
aattcatttg aaactgtgag ccaattaact tgcagtcaat caagtcgccc cccatctctt   1563660
gtaaatatat tcttatttga ctaaaccatt cctgaggaat gtcctgattt agcagataaa   1563720
ttttcaaatg actattgtgt ctacagagtg acttcatcgc cgtttcgatt tgtcgaatat   1563780
aagcgtaatc acctgcaaat actacagcgc gtttggtatt tctcatttta aatccttatc   1563840
atttatttta aatagtctag tttaatattc gtgcaacaat ctgactgtta taggtttcat   1563900
catcaataaa ttcaatatct tggtcgaaat tatgttctgc agtatgttta tgagaaaatt   1563960
taaccttagt tttagctccc attttcatcc attcatactc tgagtcaata tggcctacat   1564020
ccaaaacttg atagcccatc tggcatagat tataactcag aacttttgct gtaggtccaa   1564080
gcatacataa aatcaagcga ccaccagcat acttttcaat ttcttgttca agttcatgaa   1564140
ctctagaaaa ggcactatga gaaggacaga taattcgctt aatagaattt gcctcatcga   1564200
ataaatcatt tccgacacct gaacgagaag tcgcaccttc gactatcagt aagtcacggt   1564260
tttcccaaat gcttttcaat ttttcaaatt gagctttagc ttgactcttg tcttcaaaat   1564320
cgatataagg gcgagataca aaggttgagc cataccatga atcactgcat aactctctgt   1564380
aaaaatccat ataatgatcc atgtgatctt tccaaaatgg aatcgcccac gatgtaaacc   1564440
taaaacgatc tgtaaaagca tcaggaaggc acactactaa atcttctcga ctttcttggc   1564500
cgataatgtc cctcatgatt gaaaccaact cttcatcata atcctggtag ggaattgaat   1564560
gccctgcaag catattgatt tccccatctc caaaacgaac taaagaagag ttgtgttcaa   1564620
taatataatc caaggtttca tctatccctt tcacctggat tatatcaagc ggtttttcta   1564680
gcatatcctt agttatcaat ttttgcaaat cagccaacat tcgttcagga tgttcacttg   1564740
aatacaacct ttggccatta ttcccatttt gagatttata aaaggctagt ataggtttag   1564800
atagatgagc catttctgca acgatatcgg atgttgaagt cagtaggttg atatctaaat   1564860
aagcatccat cttctccttc aactcgtcta gcttatctct agaaattgcc ggatagagct   1564920
gaatattagg ataacgatta gacaaatcat ataattttgg ccccatagct gtccaagcag   1564980
caatttgaaa aacaacattt ggcaactgtc cagccaagta atccaattgt tcgatatact   1565040
gagaagccgt aaacgttaaa caagttaaac ttggaagttg tcgaaaacag gtaagatgtc   1565100
cgtttttctt aaaatcttta atcgtatcaa tcataaagga aactttccca ttttcgaaaa   1565160
cgatttgtcc taactctccg tgctgagtcg attgaaaagc tagtagcgtt ttttcttgtt   1565220
cttgcaaaga ttttaaaaag ttctcatctg cactaccatg attgatatcc aaatatagat   1565280
ttgttgactt tttcagctta tctaagaccg gtggaacaat ttgtggatgc aatctcacat   1565340
tattatatac agctaatttt tttaatttat ctcccatatc cgtccaagct gcgatatgaa   1565400
ataccacctc aggtagagct gtaactagct cttctattcc ttctaaatct tgggaattcg   1565460
ttaaggttaa gcaagaaaat tccttatcta gaggcgatat tagttcaaat tctcccatat   1565520
ggtgttgtaa aatctgactc cactccaaat catggaattc ccaccataaa tcacgataac   1565580
gattggctgt caaggtagtc cagggttttc tgtaggtcgt aaaatgaatc accactggtt   1565640
tatcattaaa agccagatgt tcctgccaat tgttatacaa agccacaata tcatgcccta   1565700
cttgtaaatt ataagctcga cctagttcta accaatcatc ttgcaagacc tgattaaaaa   1565760
tcgtttgatc accattaaaa tgctcgaaac ggccttcttc aacttccttc attgtaacaa   1565820
tgctctgttc aattagtcgt tcttttaatt tctcttgacg ccatttttta ttgttgatta   1565880
ataaaacacc tgcattaaat gtaattccat ctgtatcttt aactgctgcg agtgattttt   1565940
cttctaaaca aatactaaat aatttctcta aagaagtatt tacaatcaaa tcactgtcta   1566000
aatataaaac cttatcttct tggatataat ctgcaataaa atatctagca taagtaatgc   1566060
tactaatgtg atcttgcttt tcccaatctt gaaacacagt ttgttcaggt agtttaacat   1566120
cgataatctc actacctaac atgcgagcta tttttcgtgg tttgcgaaac caatctggca   1566180
tgatatcttg attcaaaata taaatcttaa catctcgatt gtggtataaa atagatttta   1566240
tcgttgtttc taactgcctg gtgtaattgc gatcccctgc tagtacaatt gttttgttca   1566300
tttcattccc ttaatcaatt cccaagtgat agattgcatc taccaataac tttttagtga   1566360
aatagccctc ttttaacaaa tagctaaagg tcttgatacg attcgtcatt tcttgatatt   1566420
cttgtagatt cattttatca actatctcat gaacctcttc cagactatcc gccataaagc   1566480
ccaagccttg atctactata aatttagcag ttgacaagct acttggtaca atgactggaa   1566540
tgcccgctgt tagataggta ctcaccttat gagatatatt caaggtatag tattggttac   1566600
tttctccctc attttgatgg gttccccaga caaggccaaa tccacccttt gataattcta   1566660
gcaacaattc ctcatctttt ttccatcctt cgatgctgag acttctagca ctagaactag   1566720
cttccccttt atttgaaaat actctcaaag gcgtatcttg agaccaattt tgtaagtctg   1566780
gaaaacgctc taaacttcca gcaaaaaaaa gttctttttt aaaagcaggg gtgtataagg   1566840
ataaatcatg aggatgatcc cacatccctt gaacaagaat cttcttagtc gtcaatcctt   1566900
cttccatcag gcgtgttttc attctctctg acggcactat caaaacatct gatagattat   1566960
acatatacag ataatctttc atgagataat agttactatc aaacatgagg ggaacaacat   1567020
catggataaa gcaaataatt ttcacctgca tatcctttag cttatcaaac aagagacgat   1567080
caaattcaaa accattccag gttggagact gaaagactaa aatatcccca atagagatac   1567140
tggccataat accatccaga cgcttattca tttcagaagg actatctgaa gcaatgttgt   1567200
aaaaataaat accaacctct ctaaatccca gttgactagc tatcttttga acagcatttt   1567260
gagctaagat aaccgtacta tcaccagcca tgccgtataa atttgttaaa tgtagtttca   1567320
tattacgcta tctcattttt tattactatc tacggaagta aagacaattt ttccatcatt   1567380
cttctgtaaa tctctgtgaa ctgcatattt tgttcttcta attttgctat cactctttgt   1567440
aatctatttt tataaatcaa aatatgattg gtcaagtcat agtctgaact tgctaaaata   1567500
gctatctttt cttccctagc cccaatttca tcatacatac gcttttcact ccatgtattc   1567560
gataaagtat cagataaacc aacacggtac cagtaaacac aacgattcaa atagactatc   1567620
ctcgaagctc ttagaagtac cttccatgtc cagtaagtat cctctgcaat ttttcctata   1567680
ggaaatggta aatcttgtag taactctctc ttgaataact tcaagacagc tacagtccag   1567740
ttcccatttc tgacttcttc gacaccttcc ctatccataa ttgctttacc ttctatcact   1567800
tctagagaat catctggatc cgtaacataa gtcatataca catagcgtgt ttcatcataa   1567860
gaattataac gcccgatact aatatctgcg ttttcctttt tcaaagcacc atataatcgg   1567920
tctaaagcat catgttccaa ccaatcatca gagtctacaa aagtaatgta cgcccccccc   1567980
cgaacattca atacctaggt tacgagctga tgaaagaccg ccgtttgctt tctcaaaata   1568040
tttgaaacga gaatctttct ctacaaattc ttcacatatt ttggatgaat gatctggaga   1568100
gccatcattg attaataaac actcaaaatt ttgatacgtc tgattctgaa tgctatccaa   1568160
acacattcgc aaataattct caacgttgta gattggaact acaatactaa ttagttcgtc   1568220
tgccataaac ttattctcct ataaattgtc taatagcctc taccattttg tttggttcgg   1568280
ttgaagaaaa tatattagtt tgattgccta tatcatgact agtattttca aaggtaaaaa   1568340
ttggtttaga tagttgttga acaacggata caatattatc cacttcttta taatgattaa   1568400
tatctaaata aaaatctaaa ttatccaaaa tttttcgata atcaaatgga gaaaaacaag   1568460
gataaatcgt aacattgcta tatcttaata aagcaacgac actagacgca aaatatgtat   1568520
gtgctagtat agaaaaatgt acctctggta aattttctat caaatattct acatgctcca   1568580
tctcacaact agctgtaaaa attgctgtat gagctttagg actgtataca agttcttcga   1568640
aactacgact aataatgtct tttctcaata aaatatcaga ccattctaac agattataaa   1568700
accaccaaac ttctctaaag cgattattgg aaattatttc ccaaggtttt accccagtat   1568760
aatgtataac actaggtaaa tctccatttt tcaactcaga aatctcatac catttatgat   1568820
ttccttctat gtgtgcgacg ctatccatcc ccaccataaa attaaaattt cggtctaatc   1568880
ttttccatct atcatggaat aacatattta aaattccttg atctccatat gctgtttcat   1568940
gatattgatt ggtcagttct aacagtttcg aacaagcatc ttcatctctc caagtatcta   1569000
cattaactaa taacattccg gagttaaaat tggtagaagg aacatcacca aaagaatctt   1569060
ctactgctgc caaggcataa ccatctagtt ctatatcaaa taaatagtct aaacttcctg   1569120
taacaatgat gtcagaatct aggtataaag cacgactttc tttgacaaaa ttaggtataa   1569180
aataacgaaa gaaagtggca taacttaaat tctttaacgg taaatgaaac tttttaagaa   1569240
catgatctac aatctttaca ttaacgattt cagattgtat agtcttcaat cgcttattca   1569300
tcatcaaaaa ccactctgac gcaatatcat cattaaatac ataaaatttt aaacaattat   1569360
tataacaaca aatagattta attgcagttt ctaatttatc tacataatca ttatctgcat   1569420
taaaaactat agattttgta ttcattaaca taatttcctt ataataaatt tcgtatcaaa   1569480
cagctataat atagaatcat tttcacctaa aaagataatt aatcacaccc taatattgta   1569540
ctgaccccaa aaagttagat tttttctgtc taacttttgg ggtgcagttc atattaaata   1569600
tctttaggtc tatttatatt ttataaagca ctctgatgtt tgaacaactt tcatatatga   1569660
tgaacggaga aattttataa aaaataatcc aactcttcaa tctgatcact aaccgtcaaa   1569720
atcagagcat ctcctactaa atgatttttc ttcatttgct tatttctctc aatttttcaa   1569780
tcattgcttg aacttggtca acagcatatg cctcctgacc tacttcatag gttttagtat   1569840
tttcaaagga taagataggc ttgccaagat tagcaaattg atcgagaatt tcttctgtct   1569900
tttcgccatg attaatatct aaaagtactt gactggtttc taccaattca ttatcgacat   1569960
ctaccaaata gtgaattccg ttaaatatag tcacgtttgg ataaattgtc atctgagcca   1570020
atcgatcact aactattact ctagctgcta tcttaaactg aatatcaggc aaggattgaa   1570080
ccaatgtctc aatttgttca atatggtctg aggcagtata gattagacaa gtgaaaggtt   1570140
cctttattgg atagatgtga gatctttgta atggatgtaa atgatggttt tgtcccaatt   1570200
ctgtccattc aagcccatga tagtaccacc aaacttcacg ataggtttgg gccgccaaat   1570260
ctttccacgg tttccgatga gaaagatagt gaataatagc aggataatcc tgaccctcag   1570320
gcaattgata atcagcaaac tgtttatgaa tgacaatatg attataatca aagtccaatt   1570380
ccaaccattt atgttcaaaa agcatattca agatgctctg atctgcctga tccaccttat   1570440
catgccattc attggttaca tcaattaatt tttgggtcat attctctttt ttccaaaaag   1570500
cattgtttac caagagaaca ccggcattaa agatttcttg accaaaataa gctctgcccc   1570560
caaaatctct aacagcagcc aaaggataat cttgtaagtc tgtagcaaac aagtcatcca   1570620
gatttttcgt tacaactaga tcacagtcca agtagagggc cttgtcttct tgcacgaaat   1570680
cagctatgaa atagcgtaaa aagactgtgt aactaatatc cgatttataa catgaaattt   1570740
gctcagaagt tacccgacaa ttaataattt ctgagtcaaa cttctctaag cgcttattta   1570800
attgcttaat ccattcattt ggaaaatcgc tatgaatcag ataaaaacga atcgaacgat   1570860
tatgataaca aatagacttg attgtcgtta aaacttggtc tacatagcca tagtttgctg   1570920
cgaggacaat ggctttcttt tcactttcct cttgtctcga tagctgattt aaaagccttt   1570980
gtttcatttc aaactcttta tacgttgctg tgtcagataa accactagct tgaccgttgg   1571040
cgagactgac ttccaacatc tgacgataaa ctgccaagtg tttctctaga ggataaccca   1571100
tattagctag tagcgtaata cgttcagaca tagcatcaac taaagcgtgc atccactttt   1571160
ctgtccaaac tcttgataaa ctaccttttc taatccgata agcataaaga cttttattta   1571220
aataaattac cttttctgat aataaatata ccttttgatt gaggtaacca tcttctccta   1571280
atttacctat gtcaaagcgc aactgctcaa acaatcttgc cttatagagt ttaccccaag   1571340
cagatatcaa agcaaaactc ttcatttctt gagtttcata caagttctca aagatagaaa   1571400
cattatcata tactttctca taataggagt ctcccaatat atgaaagtag aacattcctt   1571460
cactttcgtt gaaagaataa taattaccaa ctgcaatatc agcctgatac tctactattt   1571520
ttttatatag agtttctaca taatcttgct caatccaatc atccgagtcc acaaaggtca   1571580
cataatttcc ggacatatta ttcagaccgg tgtttcgtgc ggcagaaaga ccagcatttt   1571640
cttgttctat atagagaatt cggtgatcca tttctgaaaa ttctttacaa atttcacctg   1571700
aagcatccgt agaaccatca ttaacgacaa caatctcaat atttttatat gtttgagtaa   1571760
taatactatc taggcacttc ctcagatagt tttccacatt gtatactggt acaatgactg   1571820
ttattttatc atccactagc aattttctcc ttgatttatg tgcgcgagtt agtttagcct   1571880
aactttacag gttgtcttac tcttcttcat cacgtttacg gcgtttcgca accaatccaa   1571940
tacctgtaac agctgctaga actccaagta acacagatcc aattgacgac tcagtacctg   1572000
tattaggcaa ttctttttgg gatttacctg tcgatccaga agtatttcca acttgtgagt   1572060
tcgaatggtt tgctgaattt gaaactgatg tacttgctga agctgacgca cttgttgatg   1572120
ctgaagctga agcactggtg cttgctgagg ccgaggcact ggtgcttgct gaagccgacg   1572180
cactcgttga tgctgaagct gacgcacttg ttgaggccga agctgaagca cttgttgatg   1572240
ctgaggctga cgcactggta cttgctgaag ctgaggcact ggtgcttgct gaggctgagg   1572300
cgctggtact tgctgaggct gacgcactgg tgcttgctga agctgaggcg ctggtacttg   1572360
ctgaagccga tgcactcgtt gatgctgagg ctgatgcact agtacttgct gaggctgacg   1572420
cactcgttga tgccgattca gacgctgaga tacttgctga ggctgaggca ctggttgatg   1572480
ctgaagccga cgcactggtg cttgctgaag ccgatgcact agtacttgct gaggctgacg   1572540
cactcgttga tgccgattca gacgctgaga tacttgctga ggctgaggca ctcgttgatg   1572600
ctgaagccga cgcactggtg cttgctgaga ctgatgcact ggttgacgct gaagccgatg   1572660
cactcgttga tgctgatgct gatgcactcg ttgatgccga ttcagacgct gagatacttg   1572720
ctgaggctga tgcactggtt gatgctgatg ctgatgcact agtacttgct gaggctgacg   1572780
cactcgttga tgctgatgct gaggcacttg ttgatgccga agccgaagca ctggttgatg   1572840
ctgaagctga cgcacttgtg cttgctgaag ctgacgcact ggtacttgct gaagccgagg   1572900
cactggttga cgctgaggct gaagcacttg ttgaggctga agctgatgca ctggttgatg   1572960
ctgaggctga agcacttgta cttgctgagg ccgaggcgct tgttgatgcg gaagctgacg   1573020
cactggttga tgcagattca gaagctgatg tgcttgctga ggctgacgca ctcgttgatg   1573080
ctgactcaga cgcactcgtt gacgctgaag ccgaagcact ggtgcttgct gaagccgagg   1573140
cacttgttga tgcggattca gaggcactgg ttgacgctga gactgaagca ctcgttgatg   1573200
ctgaagccga cgcactggta cttgctgaag ctgaagcact tgttgatgct gaagctgatg   1573260
cactcgttga tgctgaagcc gacgcacttg ttgatgctga ttcagacgct gaggtacttg   1573320
ctgaagccga cgcacttgtc gacgctgagg ctgacgcact ggtacttgct gaagctgagg   1573380
cgcttgtcga cgctgaggct gaggcgctag tacttgctga agctgatgca ctagtacttg   1573440
ctgaagcgga cgcactcgtt gatgctgagg ctgaggcgct agtacttgct gaggctgacg   1573500
cactggttga tgccgattca gatgcactgg ttgaggccga cgcacttgtc gacgctgagg   1573560
ctgaagcact ggtacttgct gaggctgacg cactggtact tgctgaagct gaggcgcttg   1573620
tcgatgctga ggctgacgca ctggttgatg cagattcaga agctgatgtg cttgctgagg   1573680
ctgacgtact cgttgatgct gactcagacg cactcgttga cgctgaagcc gaagcacttg   1573740
ttgacgctga tgctgaggcg ctagtacttg ctgaagcgga cgcactcgtt gatgccgatt   1573800
cagacgctga gatacttgct gaagctgaag cacttgttga tgctgaagct gatgcactcg   1573860
ttgatgctga ttcagacgct gaggtacttg ctgaagccga cgcacttgtc gacgctgagg   1573920
ctgacgcact ggtacttgct gaagctgagg cactggtgct tgctgaggct gaggcgctgg   1573980
tacttgctga ggctgacgca ctggtgcttg ctgaagctga ggcgctggta cttgctgaag   1574040
ccgatgcact cgttgatgct gatgctgatg cactagtact tgctgaggct gacgcactcg   1574100
ttgatgccga ttcagacgct gagatacttg ctgaggctga ggcactggtt gatgctgaag   1574160
ccgacgcact ggtgcttgct gaagccgatg cactagtact tgctgaggct gacgcactcg   1574220
ttgatgccga ttcagacgct gagatacttg ctgaggctga ggcactcgtt gatgctgaag   1574280
ccgacgcact ggtgcttgct gagactgatg cactggttga cgctgaagcc gatgcactcg   1574340
ttgatgctga tgctgatgca ctcgttgatg ccgattcaga cgctgagata cttgctgagg   1574400
ctgatgcact ggttgatgct gatgctgatg cactagtact tgctgaggct gacgcactcg   1574460
ttgatgctga tgctgaggca cttgttgatg ccgaagccga agcactggtt gatgctgaag   1574520
ctgacgcact tgtgcttgct gaagctgacg cactggtact tgctgaagcc gaggcactgg   1574580
ttgacgctga ggctgaagca cttgttgagg ctgaagctga tgcactggtt gatgctgagg   1574640
ctgaagcact tgtacttgct gaggccgagg cgcttgttga tgcggaagct gacgcactgg   1574700
ttgatgcaga ttcagaagct gatgtgcttg ctgaggctga cgcactcgtt gatgctgact   1574760
cagacgcact cgttgacgct gaagccgaag cactggtgct tgctgaagcc gaggcacttg   1574820
ttgatgcgga ttcagaggca ctggttgacg ctgagactga agcactcgtt gatgctgaag   1574880
ccgacgcact ggtacttgct gaagctgaag cacttgttga tgctgaagct gatgcactcg   1574940
ttgatgctga agccgacgca cttgttgatg ctgattcaga cgctgaggta cttgctgaag   1575000
ccgacgcact tgtcgacgct gaggctgacg cactggtact tgctgaagct gaggcgcttg   1575060
tcgacgctga ggctgaggcg ctagtacttg ctgaagctga tgcactagta cttgctgaag   1575120
cggacgcact cgttgatgct gaggctgagg cgctagtact tgctgaggct gacgcactgg   1575180
ttgatgccga ttcagatgca ctggttgagg ccgacgcact tgtcgacgct gaggctgaag   1575240
cactggtact tgctgaggct gacgcactgg tacttgctga agctgaggcg cttgtcgatg   1575300
ctgaggctga cgcactggtt gatgcagatt cagaagctga tgtgcttgct gaggctgacg   1575360
tactcgttga tgctgactca gacgcactcg ttgacgctga agccgaagca cttgttgacg   1575420
ctgatgctga ggcgctagta cttgctgaag cggacgcact cgttgatgcc gattcagacg   1575480
ctgagatact tgctgaggct gaagcacttg tgcttgctga agccgaggca cttgttgatg   1575540
ctgattcaga tgctgaggta cttgctgaag ctgaggcact ggttgatgcg gattcagacg   1575600
cgctggtgct tgctgaggcc gacgcactgg tgcttgctga gactgatgca ctcgttgatg   1575660
ctgaagccga ggcacttgtt gatgccgatt cagacgctga gatacttgct gaggccgagg   1575720
cgctggttga cgcggaagct gaagcacttg ttgacgctga ggctgaggcg ctagtacttg   1575780
ctgaagccga ggcacttgtt gatgcggaag ctgacgcact ggtacttgct gactctgatg   1575840
cactggttga tgctgaagcc gatgcactcg ttgatgctga agctgatgca ctagtacttg   1575900
ctgaggctga cgcactggtt gatgccgatt cagatgcact ggttgaggcc gacgcacttg   1575960
tcgacgctga ggctgacgca ctggtacttg ctgaggctga cgcactggta cttgctgaag   1576020
ccgacgcact tgtcgacgct gaggctgacg cactggtact tgctgaagct gaggcgcttg   1576080
tcgatgctga ggctgacgca ctggttgatg cagattcaga agctgatgtg cttgctgagg   1576140
ctgacgcact cgttgatgct gactcagacg cactcgttga cgctgaagcc gatgcacttg   1576200
ttgacgctga ggctgaggcg ctagtacttg ctgaagcgga cgcactcgtt gatgctgaag   1576260
ccgatgcact tgttgacgct gaggctgagg cgctagtact tgctgaagcg gacgcactcg   1576320
ttgatgccga ttcagacgca ctcgttgacg ctgaagccga tgcacttgtt gacgctgagg   1576380
ctgaggcgct agtacttgct gaagcggacg cactcgttga tgccgattca gacgctgaga   1576440
tacttgctga ggctgacgca ctggttgagg ctgaggctga ggcgctagta cttgctgaag   1576500
ccgacgcact ggtgcttgct gaagccgagg cacttgttga tgcggaagct gacgcactgg   1576560
tacttgctga ctctgatgca ctggttgacg ccgaagccga tgcactcgtt gatgctgaag   1576620
ctgatgcact agtacttgct gaggctgacg cacttgtcga cgctgaggct gacgcactgg   1576680
tacttgctga agctgaggcg cttgtcgacg ctgattcaga tgctgatgtg cttgctgaag   1576740
ccgaggcact tgtcgatgct gaggctgaag cacttgttga tgctgagact gaagcactgg   1576800
tacttgctga agctgacgca ctggttgacg ctgaagccga ggcactggtt gatgctgaag   1576860
ccgatgcact agtacttgct gaggctgacg cactggttga tgccgattca gatgcactgg   1576920
ttgaggccga cgcacttgtc gacgctgagg ctgaagcact ggtacttgct gaagctgagg   1576980
cgcttgtcga tgctgaggct gacgcactgg ttgaggccga ttcagaagct gaggtgcttg   1577040
ctgaggctga cgtactcgtt gatgctgact cagacgcact cgttgatgcc gattcagacg   1577100
ctgagatact tgctgaggct gacgcacttg ttgatgctga ggctgaagca ctggttgacg   1577160
ctgaagctga cgtactcgtt gatgctgaac ccgaggcgct tgtgcttgct gaagccgaag   1577220
cactcgttga tgctgaggct gaggcgctgg ttgaggccga ttcagaagct gaggtgcttg   1577280
ctgaggccga ggcgctggtt gaggccgatt cagaagctga ggtgcttgct gaggccgagg   1577340
cgctggttga tgctgaagct gaagcactgg tacttgctga agccgaagca ctggttgacg   1577400
ctgattcaga tgctgatgtg cttgctgaag ccgaggcact tgttgatgcg gaagctgacg   1577460
cactggtact tgctgactct gatgcactgg ttgacgccga agccgatgca ctcgttgatg   1577520
ctgaagctga tgcactagta cttgctgagg ctgacgcact ggttgatgcc gattcagatg   1577580
cactggttga ggccgacgca cttgtcgacg ctgattcaga tgctgatgtg cttgctgaag   1577640
ccgaggcact tgtcgatgct gaggctgaag cacttgttga tgctgagact gaagcactgg   1577700
tacttgctga agctgacgca ctggttgacg ctgaagccga ggcactggtt gatgctgaag   1577760
ccgatgcact cgttgatgct gaagctgatg cactagtact tgctgaggct gacgcactgg   1577820
ttgatgccga ttcagatgca ctggttgagg ccgacgcact tgtcgacgct gaggctgaag   1577880
cactggtact tgctgaagct gaggcgcttg tcgatgctga ggctgacgca ctggttgatg   1577940
ccgattcaga agctgatgtg cttgctgagg ctgacgtact cgttgatgct gactcagacg   1578000
cactcgttga tgccgattca gacgctgaga tacttgctga ggctgacgca cttgtgcttg   1578060
ctgaagccga cgcactggtt gaggcggaag ctgacgctga ggtacttgcg cttgctgagg   1578120
ccgacgcact cgttgatgcc gattcagacg ctgagatact tgctgaggct gacgcacttg   1578180
tgcttgctga agcggacgca ctggttgagg cggaagctga cgctgaggta cttgcgcttg   1578240
ctgaggccga cgcactcgtt gatgctgaag ccgaagcact tgtcgacgct gaagccgacg   1578300
cactggttga cgctgaagcg gacgcactgg ttgatgcaga ttcagaagct gatgtgcttg   1578360
ctgaggctga cgcactcgtt gatgctgaag ccgaagcact cgttgatgcc gattcagacg   1578420
cacttgtcga tgctgaagcc gatgcactag tacttgctga agccgacgca ctggtgcttg   1578480
ctgaagccga ggcacttgtt gatgctgatt cagaggcact ggttgacgct gagactgaag   1578540
cactcgttga tgctgaagcc gacgcactgg tacttgctga agctgaagca cttgttgatg   1578600
ctgaagctga tgcactcgtt gatgctgatt cagacgctga ggtacttgct gaagccgacg   1578660
cacttgtcga cgctgaggct gacgcactgg tacttgctga agctgaggca ctggtgcttg   1578720
ctgaggctga ggcgctggta cttgctgagg ctgacgcact ggtgcttgct gaagctgagg   1578780
cgctggtact tgctgaagcc gatgcactcg ttgatgctga tgctgatgca ctagtacttg   1578840
ctgaagcgga cgcactcgtt gatgctgagg ctgaggcgct agtacttgct gaggctgacg   1578900
cactggttga tgccgattca gatgcactgg ttgaggccga cgcacttgtc gacgctgagg   1578960
ctgaagcact ggtacttgct gaggctgacg cactggtact tgctgaagct gaggcgcttg   1579020
tcgatgctga ggctgacgca ctggttgatg cagattcaga agctgatgtg cttgctgagg   1579080
ctgacgtact cgttgatgct gactcagacg cactcgttga cgctgaagcc gaagcacttg   1579140
ttgacgctga tgctgaggcg ctagtacttg ctgaagcgga cgcactcgtt gatgccgatt   1579200
cagacgctga gatacttgct gaggctgaag cacttgtgct tgctgaagcc gatgcacttg   1579260
ttgatgctga ttcagatgct gaggtacttg ctgaagctga ggcactggtt gatgcggatt   1579320
cagacgcgct ggtgcttgct gaggccgacg cactggtgct tgctgagact gatgcactcg   1579380
ttgatgctga agccgaggca cttgttgatg ccgattcaga cgctgagata cttgctgagg   1579440
ccgaggcgct ggttgacgcg gaagctgaag cacttgttga cgctgaggct gaggcgctag   1579500
tacttgctga agccgaggca cttgttgatg cggaagctga cgcactggta cttgctgact   1579560
ctgatgcact ggttgatgct gaagccgatg cactcgttga tgctgaagct gatgcactag   1579620
tacttgctga ggctgacgca ctggttgatg ccgattcaga tgcactggtt gaggccgacg   1579680
cacttgtcga cgctgaggct gacgcactgg tacttgctga ggctgacgca ctggtacttg   1579740
ctgaagccga cgcacttgtc gacgctgagg ctgacgcact ggtacttgct gaagctgagg   1579800
cgcttgtcga tgctgaggct gacgcactgg ttgatgcaga ttcagaagct gatgtgcttg   1579860
ctgaggctga cgcactcgtt gatgctgact cagacgcact cgttgacgct gaagccgatg   1579920
cacttgttga cgctgaggct gaggcgctag tacttgctga agcggacgca ctcgttgatg   1579980
ctgaagccga tgcacttgtt gacgctgagg ctgaggcgct agtacttgct gaagcggacg   1580040
cactcgttga tgccgattca gacgcactcg ttgacgctga agccgatgca cttgttgacg   1580100
ctgaggctga ggcgctagta cttgctgaag cggacgcact cgttgatgcc gattcagacg   1580160
ctgagatact tgctgaggct gacgcactgg ttgaggctga ggctgaggcg ctagtacttg   1580220
ctgaagccga cgcactggtg cttgctgaag ccgaggcact tgttgatgcg gaagctgacg   1580280
cactggtact tgctgactct gatgcactgg ttgacgccga agccgatgca ctcgttgatg   1580340
ctgaagctga tgcactagta cttgctgagg ctgacgcact tgtcgacgct gaggctgacg   1580400
cactggtact tgctgaagct gaggcgcttg tcgacgctga ttcagatgct gatgtgcttg   1580460
ctgaagccga ggcacttgtc gatgctgagg ctgaagcact tgttgatgct gagactgaag   1580520
cactggtact tgctgaagct gacgcactgg ttgacgctga agccgaggca ctggttgatg   1580580
ctgaagccga tgcactcgtt gatgctgaag ctgatgcact agtacttgct gaggctgacg   1580640
cactggttga tgccgattca gatgcactgg ttgaggccga cgcacttgtc gacgctgagg   1580700
ctgaagcact ggtacttgct gaagctgagg cgcttgtcga tgctgaggct gacgcactgg   1580760
ttgatgcaga ttcagaagct gatgtgcttg ctgaggctga cgtactcgtt gatgctgact   1580820
cagacgcact cgttgatgcc gattcagacg ctgagatact tgctgaggct gacgcacttg   1580880
tgcttgctga agccgacgca ctggttgagg cggaagctga cgctgaggta cttgcgcttg   1580940
ctgaggccga cgcactcgtt gatgctgaag ccgaagcact tgtcgacgct gaagccgacg   1581000
cactggttga cgctgaagcg gacgcactgg ttgatgcaga ttcagaagct gatgtgcttg   1581060
ctgaggctga cgcactcgtt gatgctgaag ccgaagcact cgttgatgcc gattcagacg   1581120
cacttgtcga tgctgaagcc gatgcactag tacttgctga agccgacgca ctggtgcttg   1581180
ctgaagccga ggcacttgtt gatgctgatt cagaggcact ggttgacgct gagactgaag   1581240
cactcgttga tgctgaagcc gacgcactgg tacttgctga agctgaagca cttgttgatg   1581300
ctgaagctga tgcactcgtt gatgctgatt cagacgctga ggtacttgct gaagccgacg   1581360
cacttgtcga cgctgaggct gacgcactgg tacttgctga agctgaggca ctggtgcttg   1581420
ctgaggctga ggcgctggta cttgctgagg ctgacgcact ggtgcttgct gaagctgagg   1581480
cgctggtact tgctgaagcc gatgcactcg ttgatgctga tgctgatgca ctagtacttg   1581540
ctgaggctga cgcactcgtt gatgccgatt cagacgctga gatacttgct gaggctgagg   1581600
cactggttga tgctgaagcc gacgcactgg tgcttgctga agccgatgca ctagtacttg   1581660
ctgaggctga cgcactcgtt gatgccgatt cagacgctga gatacttgct gaggctgagg   1581720
cactcgttga tgctgaagcc gacgcactgg tgcttgctga gactgatgca ctggttgacg   1581780
ctgaagccga tgcactcgtt gatgctgatg ctgatgcact cgttgatgcc gattcagacg   1581840
ctgagatact tgctgaggct gatgcactgg ttgatgctga tgctgatgca ctagtacttg   1581900
ctgaggctga cgcactcgtt gatgctgatg ctgaggcact tgttgatgcc gaagccgaag   1581960
cactggttga tgctgaagct gacgcacttg tgcttgctga agctgacgca ctggtacttg   1582020
ctgaagccga ggcactggtt gacgctgagg ctgaagcact tgttgaggct gaagctgatg   1582080
cactggttga tgctgaggct gaagcacttg tacttgctga ggccgaggcg cttgttgatg   1582140
cggaagctga cgcactggtt gatgcagatt cagaagctga tgtgcttgct gaggctgacg   1582200
cactcgttga tgctgactca gacgcactcg ttgacgctga agccgaagca ctggtgcttg   1582260
ctgaagccga ggcacttgtt gatgcggatt cagaggcact ggttgacgct gagactgaag   1582320
cactcgttga tgctgaagcc gacgcactgg tacttgctga agctgaagca cttgttgatg   1582380
ctgaagctga tgcactcgtt gatgctgaag ccgacgcact tgttgatgct gattcagacg   1582440
ctgaggtact tgctgaagcc gacgcacttg tcgacgctga ggctgacgca ctggtacttg   1582500
ctgaagctga ggcgcttgtc gacgctgagg ctgaggcgct agtacttgct gaagctgatg   1582560
cactagtact tgctgaagcg gacgcactcg ttgatgctga ggctgaggcg ctagtacttg   1582620
ctgaggctga cgcactggtt gatgccgatt cagatgcact ggttgaggcc gacgcacttg   1582680
tcgacgctga ggctgaagca ctggtacttg ctgaggctga cgcactggta cttgctgaag   1582740
ctgaggcgct tgtcgatgct gaggctgacg cactggttga tgcagattca gaagctgatg   1582800
tgcttgctga ggctgacgta ctcgttgatg ctgactcaga cgcactcgtt gacgctgaag   1582860
ccgaagcact tgttgacgct gatgctgagg cgctagtact tgctgaagcg gacgcactcg   1582920
ttgatgccga ttcagacgct gagatacttg ctgaggctga agcacttgtg cttgctgaag   1582980
ccgaggcact tgttgatgct gattcagatg ctgaggtact tgctgaagct gaggcactgg   1583040
ttgatgcgga ttcagacgcg ctggtgcttg ctgaggccga cgcactggtg cttgctgaga   1583100
ctgatgcact cgttgatgct gaagccgagg cacttgttga tgccgattca gacgctgaga   1583160
tacttgctga ggccgaggcg ctggttgacg cggaagctga agcacttgtt gacgctgagg   1583220
ctgaggcgct agtacttgct gaagccgagg cacttgttga tgcggaagct gacgcactgg   1583280
tacttgctga ctctgatgca ctggttgatg ctgaagccga tgcactcgtt gatgctgaag   1583340
ctgatgcact agtacttgct gaggctgacg cactggttga tgccgattca gatgcactgg   1583400
ttgaggccga cgcacttgtc gacgctgagg ctgacgcact ggtacttgct gaggctgacg   1583460
cactggtact tgctgaagcc gacgcacttg tcgacgctga ggctgacgca ctggtacttg   1583520
ctgaagctga ggcgcttgtc gatgctgagg ctgacgcact ggttgatgca gattcagaag   1583580
ctgatgtgct tgctgaggct gacgcactcg ttgatgctga ctcagacgca ctcgttgacg   1583640
ctgaagccga tgcacttgtt gacgctgagg ctgaggcgct agtacttgct gaagcggacg   1583700
cactcgttga tgctgaagcc gatgcacttg ttgacgctga ggctgaggcg ctagtacttg   1583760
ctgaagcgga cgcactcgtt gatgccgatt cagacgcact cgttgacgct gaagccgatg   1583820
cacttgttga cgctgaggct gaggcgctag tacttgctga agcggacgca ctcgttgatg   1583880
ccgattcaga cgctgagata cttgctgagg ctgacgcact ggttgaggct gaggctgagg   1583940
cgctagtact tgctgaagcc gacgcactgg tgcttgctga agccgaggca cttgttgatg   1584000
cggaagctga cgcactggta cttgctgact ctgatgcact ggttgacgcc gaagccgatg   1584060
cactcgttga tgctgaagct gatgcactag tacttgctga ggctgacgca cttgtcgacg   1584120
ctgaggctga cgcactggta cttgctgaag ctgaggcgct tgtcgacgct gattcagatg   1584180
ctgatgtgct tgctgaagcc gaggcacttg tcgatgctga ggctgaagca cttgttgatg   1584240
ctgagactga agcactggta cttgctgaag ctgacgcact ggttgacgct gaagccgagg   1584300
cactggttga tgctgaagcc gatgcactag tacttgctga ggctgacgca ctggttgatg   1584360
ccgattcaga tgcactggtt gaggccgacg cacttgtcga cgctgaggct gaagcactgg   1584420
tacttgctga agctgaggcg cttgtcgatg ctgaggctga cgcactggtt gaggccgatt   1584480
cagaagctga ggtgcttgct gaggctgacg tactcgttga tgctgactca gacgcactcg   1584540
ttgatgccga ttcagacgct gagatacttg ctgaggctga cgcacttgtt gatgctgagg   1584600
ctgaagcact ggttgacgct gaagctgacg tactcgttga tgctgaaccc gaggcgcttg   1584660
tgcttgctga agccgaagca ctcgttgatg ctgaggctga ggcgctggtt gaggccgatt   1584720
cagaagctga ggtgcttgct gaggccgagg cgctggttga ggccgattca gaagctgagg   1584780
tgcttgctga ggccgaggcg ctggttgatg ctgaagctga agcactggta cttgctgaag   1584840
ccgaagcact ggttgacgct gattcagatg ctgatgtgct tgctgaagcc gaggcacttg   1584900
tcgatgctga ggctgaagca cttgttgatg ctgagactga agcactggta cttgctgaag   1584960
ctgacgcact ggttgacgct gaagccgagg cactggttga tgctgaagcc gacgcacttg   1585020
ttgatgctga agctgaggcg ctttgactag cacttactga gagtgactta gactgtgaaa   1585080
gtgactgact ggtcgtgcta gattcaacta cctttcctcc accattgaag tagttaattc   1585140
caattctatc tgttctagca gcgtaagggg taaatgtaaa ggatgtatcc gttccagtaa   1585200
ttggtacagt ccaagatgat gttaatccat atcctttctt agcaaagaaa ccattcattt   1585260
gggcaccatt tccccaagta tacccactac cctgcgtcgt cattgtagat gtattatagg   1585320
atagaacctg tctaccattt ttgtcagtaa tgtagttctt tacacctgaa ggtttaccaa   1585380
gatcactgcc aagggttaac attgtttgtg ttgaagtacc tgaattatag atagaatatc   1585440
caggacgcat acttgatata ttaccaagat catttgtttt aggattcaca tacgtaaccg   1585500
tataggtaaa ggtcaatttt gaaccatcat ttgtcacttt caatttatag taaattggaa   1585560
cacgatatac cgaatctaca ccttcacctg tataaacttt tgtctcactt ttagcaatgt   1585620
ttagacttgc attaattgca ggggcgccat ttacaatcgt attgccagaa aaaacagcag   1585680
cattttttat agaagccagc aattgctcga tggaatccac tgaacgcttg cgtcgcttag   1585740
cataagattg gagattgaca tttgtaactg atgctacata atcactagct ggtttcttac   1585800
gatcttcttc gaccttctta gcagttgctt ctgtagcggc agctgtttgt gaacctacca   1585860
cagtagatga tgcagaaata cttgtcgaag ccgatgtact tgctgattct gatgcacttg   1585920
tacttgctga ggtcgaagcg ctggttgagg ctgactcaga tgcagatgta cttgccgact   1585980
ctgaagctga caaactagtt gaactcgctg aattacttgt agatatcgta cctagaacta   1586040
ctgtatcatt tgttgccaaa gcatccgttt tctctacagt tttttcaagt actgctgact   1586100
catttgtaaa taccttcgtt tgagttgcaa cggttccact tatgacagct cccgcagcaa   1586160
ctatcccctt gaggatatca agcccagtaa ttgaatgact tactttatct tctaccgttt   1586220
cggtcatgac ctgagtagta tcaacaccac ctcgcaagac cttaaacaag ccaaaaagag   1586280
aagtcgaggc ccgtagccaa tgcttccctg atttgattaa tttgaaccga gttactcggt   1586340
ctgtttctct atattcaccc ttctgacgtc taaaaaatat tttgaaattt cctttcgagt   1586400
attattttca tgtatggata taaataaatt accatactat aattatagaa tagggaaccc   1586460
aaaatagcaa gaaacttgag gtatttttgc taaaaaaaaa aagcatttta ctattttgta   1586520
tatatatata tatatattat aagataagtt ttttataaag acacgcaaat gagtataaat   1586580
cagctaattt ttggtttata ttcctatttt tatgcataat tattctttca ttctctaatt   1586640
tgtgaatcaa tatatctgat tagaaaacta ccattgagtt tttgctccac ctcattagtc   1586700
cgctcaaaac gccgtccgct aatcttgcca tagactttct cccctctagg agcccctgca   1586760
taaggacgat agaggtagcg gtcgattccc gtttcgtcaa tatataggac tggtaaatct   1586820
tttaggttat ccaaaatatc aagaaactca gaaactttct caggcttttg ttccctaaaa   1586880
ctggtcgtct tttttaaaat gaccttaatc tgctttaaaa ctgcccatac ggagggcaaa   1586940
gcacaatcaa aacgggccgc aatttcccgt aaaaaagcgt ctggatgagc ctctacaaag   1587000
gctttcaatt cttctaaagg gatcttacgc tttttgacga ctcgcttttt ccgctctaag   1587060
ttcccttgtt tacgtctttc ttttcccacg tgaagagagt tctgacgccg acatcaaaaa   1587120
ctttggccgc ctcgacatgt ctgtgccctc ctttaatgga atctaatgct ccttgtttaa   1587180
aatcagtact atatgcatag ctttattaga ccatgcttat tttaaactaa gcaactatag   1587240
atagagaaat gaaataaaat ctgaattcga atgtgataag gagttagaaa ttgaaacaat   1587300
aggattcccc cattattcac acaaaaataa aaccactaaa aaacagagct tgccagcatt   1587360
cttgaaaagt agtataatta ttgcatgcgc aatcatcttg tgacgcagag actgcccgtt   1587420
aatggacttt cttctattta tgactctaaa aagaaaggag acactatgac ctatttggaa   1587480
aaatggtttg acttcaatcg gcgtcagaaa gaaattgaaa gtctcttgga agagaccatt   1587540
gcccaacaga gcgagcaaag tctgaccttg aaagagttct acctgctcta ctatctggac   1587600
ttggctgaag aaaaatctct acgccagatt gacctgccag ataagcttca tctgagcccg   1587660
agcgcagttt ctaggatggt ggctcgcttg gaagctaaaa attgcggtct actcagtcgc   1587720
atgtgttgcc atcaagatag acgctctagt tttatctgcc tgacaaatga tgggcaaaag   1587780
acactggcct cgctacaaaa gactgtcgaa gaaagcttgg aagcaggttt ggatttcttg   1587840
atttaagatg attttaaaaa aagttgcgtg cgcaatcatt tttcttgaca ttctctttta   1587900
taaggagtaa aataaagtta gcattaaaca aaggagtttt aaacatgatt gaaattacct   1587960
atatagatgc cagcaagaac gaaagaactg tgactttcga gtcttatgaa gactttgaac   1588020
gttcgcaaca agcttgcctt atcggcgtcg cagactacta ccctgtccaa aaattaactt   1588080
acaagggtca taatttggac taccatggga cttatggaga tatcttcttc tatctcatga   1588140
aacaagattt aagccaatat aactaaaaaa aggagaaata caatggcaaa agcaattaca   1588200
gatgcaacat tcgaacaaga aacaaaagac ggtttggtct tagtagactt ctgggcaact   1588260
tggtgtggtc catgtcgtat gcaaggtcca atcttggaca aattgtctga agaactttca   1588320
gaagatgtct tgaaaatcgt taaaatggac gttgatgaaa atccaaacac agctcgtgct   1588380
tttggaatca tgtctattcc aactcttctc ttcaaaaaag acggccaagt tgtcaaacaa   1588440
gttgcaggtg ttcacacagc agaacaaatc aaggccatca ttgctgaatt gagctaatca   1588500
aacgagagac caagtacttt ctttggtctc ttttttcttg ccctttgcca tttttcaaaa   1588560
aatatgctag actatagtag attgaaacta gaatagtaca cctctacttc taaaacattg   1588620
ttagaaatcg atttgactgt cctgatcgat ttgtcctgtt cttatttcat tttactatat   1588680
aagtagaata ttacgatgtt tgggatatgc catcgctaaa aaaacctcga tttggtattt   1588740
tttagctccc taatgggagc tttttgcgtg ctctgaacat ttcccatttt ggaaggagta   1588800
ctatgaaacg tcaattagcc ttggtcgtct ttagtggtgg tcaagattca acaacctgcc   1588860
ttttctgggc atgcaacact atgaaacagt cgaagctgtc acctttgcct acggccaacg   1588920
tcatcacctc gaaattcaaa ttactagaga aatcgctaag gaacagggca ttcgtcacca   1588980
tatcctcgat atgtctctgc tgggacaaat cactgctcag ccagactttg cgacgattca   1589040
tatttcctac attcctgaca agctctgtgt cgagtcaaaa tccctcaaac tatatctatt   1589100
tagctaccga aaccacggag atttccacga aaactgtatc aacaccatcg ggaaagactt   1589160
ggtcaacttg ctagaccctc gctatttaga agtctgggga aaattcactc cgcgcggtgg   1589220
catttcaatc gacccctact acaactacgg taagcaagga actaagtatg agggcttggc   1589280
agaacaacgc ctcttccaac acgaccttta tccagagaaa attgacaacc gctaaagtca   1589340
tactcaatga aaatcaaaga gcaaactagg aagttagccg caggttgctc aaagcactgt   1589400
tttgaggttg tggatagaac tgacgaagtc agatcaaaac actgttttga ggttgtggat   1589460
agaactgacg aagtcagatc aaaacactgt tttgaggttg tggatagaac tgacgaagtc   1589520
agcttaaaac actgttttga ggttgcagat agaactgacg aagtcagctt aaaacactgt   1589580
tttgaggttg cagatagaac tgacgaagtc agcttaaaac actgttttga ggttgcagat   1589640
agaactgacg aagtcagctt aaaacactgt tttgaggttg cagatagaac tgacgaagtc   1589700
agatcaaaac actgttttga ggttgtggat agaactgacg aagtcagtaa ccatactacg   1589760
gcaagatgaa gctgacgtgg tttgaagaga ttttcgaaga gtatcatacg aaaaagccct   1589820
gttcctcaag atgaggagca aggctttttg agtttcaatt attcttctgt tccaaggaaa   1589880
ttttttgcaa caagggctgc aagaactcca ccagcgattg gtgcaaggat gaaaatccaa   1589940
acttgttgaa gggctgcgcc gcctaccaag acagctggtg ccaagctacg agctgggttt   1590000
actgaaagtc cagtaatctt caatccgaca agaatcatcg ccatcaatga caaaccgatt   1590060
accaaaccag caatcgcgcc attgcccttg ctttctgaag tcacagtcat gataaccaat   1590120
acaaacaaga aagttgcgat gacttcaaac aagaaaccac caaagacagt gacaccgttt   1590180
gccaaggcat tttcaccaag actagcagtt gacatacctg agttagccaa gaggaagaag   1590240
acagcgccag aagcgatgaa agctccaaca acctgaccaa ggatgtagtt tacaagttct   1590300
gaagatgaca aacgtttgtt tacaaacata gcaatcgaaa cagccgggtt caagtgagca   1590360
cctgaaacag ttccgattga gtaggctgcc accacgattg ccaaaccaaa ggcaaaggcg   1590420
attccaaggt gaccaaggcc atcaagacca tttccaaaaa caacagctcc tgtcccgacg   1590480
aatacaaaca tgaacgtacc gattaactca gcaacaaatt ttttcatttt ctttctcctt   1590540
ttttcaaaaa ctagatacta gtctatcaaa agtaggaaag ggtttcaaga aaattgattg   1590600
gaaatttttt gaaaatcata gaactattag ctaatcccta gtattgaaaa gactggatag   1590660
cttctttcag gtcatcttgt aaactatttc tctggtcaag ttggacatag acttccacca   1590720
gacaggatct aaagttggaa aatttgtaaa aatcctccct ttcttctatc ggaaaatcaa   1590780
cagtttttat ccaagaagct acttgttctt gctccaactt cccttgtaaa ataggttcat   1590840
agatcactct tgctaaacgc caatcctcat catctgtaaa gcgaatcgac attcttttaa   1590900
atagttggcc aagtatatca aatacttcat gaactctgtt tttaggaaag tctggatgac   1590960
aaaccacctc tgtcagtaaa tcggctccat gtgcaaaagc gtgaacccaa ccatactgac   1591020
ttgagaaacc ccttgtatcc ttttcttttg aaagatagtg caagccttga tttaaaagga   1591080
cattacgaat ttctggagaa ggatttccca aatgatcaaa caaccactgg atttcttcct   1591140
ggttataatt tggtttttct tctgctattt ttcttagtaa atcttgatac atggtcaata   1591200
cctctacatt tctagcaact gttcaaaaag gcagtcttaa atgactcaat attgaattct   1591260
caattaaata caatctgata taaaatgacg taaataacta tcaataccag ttctacagta   1591320
agttcaaatt taacatcacg accttcaacg acatttttga aaatagctac aactaagaca   1591380
aatagaatga cgcttaacaa gcccataaac atcattctaa aaaatttttc tattccccta   1591440
ctctcccaac tcagcactat aggagataat ctggtcaact gtgtcagaca agaattggat   1591500
ggtatcacgg agtggtttgt ctgttgaaat atcagcaccg ataatcatgg ctgactcaag   1591560
tggtgtcttg ctaccacctg atttgaggag attgagccag tcttcagctc cagtttcaga   1591620
atgttttaga tgaaggtaac cagcagtcga gataactagt cctgctgagt aagtgtaact   1591680
atacaagccc atatagtagt gagcttggcg catccaagtc agagttgcat catcgtcaat   1591740
ttcaatagca tctccccaga aatccgtcaa aacttccttc ataatgctgt tgagcttgct   1591800
tgctccaaag gtctcccctt cttcaatcaa tgtatacacc ttacgctgga aggcggcttc   1591860
caagaggtgg gtgataaagt tatggaagta ggtgtctgtc aagcgatgag ccagagcgaa   1591920
gcgtttttga cgtgggtcat tagactggtt ctccaagtaa tcactgagta gcaattcatt   1591980
gaaggttgac ggtgcttcaa catagtaggt cgacatatgg gcattgaagt aactttgatg   1592040
attgtctgaa aagatgaatt gaccagaatg cccgatttca tgaatcaagg tatagacatc   1592100
gctcaaacgg cctgtccagc tcatgagtac ataagggtgt acgcgatatg ggtccgccgc   1592160
ataaccaccg gaatccttgc cactgttagc agcaaagtcc acccagcgct cttcttggta   1592220
acgagcaact tcctgacaat attcttgccc caaaggttct accgacttca tgaccaaatc   1592280
ataggcatcg tcaatagtca cttcaggatt cagggcgctg tccaagtcca atttccagtc   1592340
tgcaaaggtc atcttttcaa gaccatttac cttggcaaca tgcttgaggt atctctgagc   1592400
gactggtgca aagtccttca tgatgaggtc aatctggcgg tcaaacatga cacggtccac   1592460
ttcttgttca gctagaagat agtcaaagac agagtcgtat cccttcatat cagccaagag   1592520
tttttcagac ttgacctgag ccagataggc tgctgcagcc gtattttggt gcttacgaag   1592580
tccctctgag aaggaacgga aggatttctc acgaacctca gcatcctcat ggttttggta   1592640
gaaattctca taggtcacaa agctgttttt gtaggtcttg ccatgggctt caaagtcagc   1592700
catttcaaaa tccccagctc gcatcttagt ataaatgtcc tgcggactgt agaaaacttc   1592760
accgagattt gtcaaggcct tctccacatc tgcccctaag tagtgggctt ttttgatttt   1592820
agcctgacga atggcagctg ttaaatgtgg caatttaccc aaacggtcca agacttcctc   1592880
atctgctgcc accaaggcat cgtcaaagaa ggtcaaggct acgctggcat ctgtttcaaa   1592940
ttccatccca gcttgggcaa tattggcaaa ttcgtcattg ctatagtccg tcgtctgagg   1593000
cataaaacca tagttgccaa tatggctcat ctgaatgtag atctgttcca attccgcaaa   1593060
ggccttctcg aaatcctcaa aagtgtgaag attgcccttg taatcacggc taaactggtt   1593120
gatgtcttcg cgagctttct cgattgcacg caagaaatcc tcacggtctt ggtatagggc   1593180
tgttaagtcc cagagttcct tctctggaaa ttctgaacgg tgtttttgtt ccattttctt   1593240
cctcttattt ctctaattct actaaaacac taagggctga taaagcgtaa agcggtgctg   1593300
tttctgctcg caaaatacga ggacctaggc ctgccaaaac ggctccttta gcttcaaaac   1593360
tttcgatttc tgcaggtgag agaccgcctt ctggaccaaa gataaagagc agtttggctc   1593420
ctgtttcaag accagtgact gcttgcagaa gcgcagcggc ttctccttct ttagctgatt   1593480
cttcataggc tactatgata gagtcaaact ggtccagctg agctagaaaa tctgcttttt   1593540
tctcgaaaag tttaatactt ggtacaatat tacgcttgct ttgctcggct gctccaaggg   1593600
caattttttc tagtttttca acttttttac ccaatttctt gccatcccac ttggcaactg   1593660
accagtctgc aggaaaggcc cagatttggc tagcccccag ttcggttact ttttgagcga   1593720
tgaactccag cttgtctccc ttgggaaatc cagatgcgat ggtcacttgg actggtagtt   1593780
ccacattgtc atttaattct tggaccaact caaactgacg attttccata tccagcacgc   1593840
gcgccaagcg cttgatgcca tcatcaaaga ctaaggtaac ctcatcctct tctttcaagc   1593900
gcataacctg aaacatatgc ttactggttt ccttgtcctc gatagtgaca ggagagatag   1593960
cactgccttt tacaaaatac tgctgcatgc tagcctccaa tcacaccaga gatatccttg   1594020
gttttcttaa agacacaggt attccattcc ccttgaacca tgtgagtttc gaggaaaaat   1594080
ccagctgact cagccgactg gcgcaccatg tccaacttgt ccttgataat gccactcatg   1594140
atcaggtagc cttcatcctt taccaagcga taagcatcgt ctattagatg aatgaggata   1594200
tccgccaaga tattagccac aatcacatct gcctcaattt ccacaccctt aagcaaatct   1594260
ccagccgcta catggatatt ttccatgcca gggttgagct caatattttc ctgagccaca   1594320
cgaaccgcca catcatccag gtcataggcg aaaatttctt tagcccccag aagcgagctg   1594380
gcaatagaga gaacccctga accagtcccc acatctagca ccgtttcgcc accacgaaga   1594440
acctgttcca aggcaaaaag gctcatcttg gtagttgggt gggttccagt accaaaagcc   1594500
atgccaggat ccagcttgat aatcatttcc cccgcagtcg cctcatagtc tgtccaagag   1594560
ggaacgatgg tcaaatcatg agtgatacga gcaggttcat agtatttctt ccagttgtct   1594620
gcccagtctt cctcagccaa ggcagtcgta cctattttta actctcccaa atccataaaa   1594680
tctgtcaatt ctgctagacg agcctgcaaa tccgcctcaa ccactgtcac atccaccgtg   1594740
tcagggtagt aggctgtcac tacgatttct tcttgctgct ccacctctgg gaaaatctct   1594800
ccaaagcggt ccacatttcc cacatagtcc atactgtctt cgattgcgac tccttgcgct   1594860
cccagctcaa tcaagagatt ggaaaccaac tcctctccct cacgcttcac tgtaactttt   1594920
aactcttgcc atgtttccat tattaatacc aagcccgtaa aacacaaaac caaaatagga   1594980
aattctctga agacgcttgt gtctaagaga agtttatctt tttggcacag tgtttagggc   1595040
gggttcagtt tagaaatgta actgaaccat cctttctaat cacttacttt taaataatct   1595100
tttaatctct cttgcaactg aggcacaact tgactggaac taagaaattc ctcaacattc   1595160
atcagctgat agccctgtcc ttcatctccg aagatgatat tgtcaaattg ttcttgtctt   1595220
agctgaccaa ccataaagac cgatttcttg cctttaaaaa ttacgctagg ataaatcttg   1595280
ctccaaagca gacagtcttc atctaaatga attcccagtt cctcataaac ttcacgccga   1595340
gcgcattcaa aagggctttc gtccccttca cggccaccac ctggcagttc ccacatattg   1595400
gcccagggaa tacttgcctt atcatcgcgt aagatagtca aaagcttatc cccacaaaac   1595460
aaagcaatct tgcaacctgt gaaatcagaa atttctagtt ccatcttcag ttccttctaa   1595520
catttccttt tccagctcgg ctaaccagtt ttcataatat cttttctcat ccctcaacat   1595580
tcgactacta tccattttct gtctagcaat cttgagagcc ttacgagttc gatctacatc   1595640
tttcttcacc tttaattgat accaggcttg tatcacttga agattggaca gtttgagaga   1595700
cagaaacgat ttgacctgtc gaatactagc atattgctcc gcttgctcaa aatctccttc   1595760
caacaaggcg atatgaagca gggatagttg ggcaactgtc tgcatcatcg gagtagttgt   1595820
cctctcaagt aatgcttgaa actgctgttt agctacttct tccttccctt ccaaaatgga   1595880
aacttcacct tgcataccta atacaccatc cgcaaaactc cctcgtgcat cctcaggaac   1595940
tgcttgaaca aagtctttca aatcatattc ttgaggagct agcaaggtct gggcagaatg   1596000
tctcaatacc aggtaggcgt atttggtatt ttcagggtgt tgtagtaatt cccaaatttt   1596060
tgctccatcg gtgatgtcga ctggcaaaat gttatttagg aagaaagata aattaagaaa   1596120
aatccaagtc cctgcaaaat accagcttct tgtcaaaaat ccaaacaata tcgccaataa   1596180
tatcaagccg agatgaacca tcaagcctcc tgaaagcatc aggatgattc tttgatcgct   1596240
ttcatcctct tttaaaccaa tgtattgagc accaacattt ttcagaatgg ctgttctact   1596300
aagatgaaac ctgcctgact ttttggtcaa aataaaatgt cctaatccaa aagccaccag   1596360
ccgatagcct gtcaagtagc cacaaaaagc atgacccagc tcatgaagaa taaagattaa   1596420
atacatgctt agaagagcga aggcataacc aaaagtaaag gctaaaactg cggaataccc   1596480
caactctgca aatgcgattg ttccacaagc aaaagctagc ataataaaga caacagctag   1596540
cacataaacc aaataagtcc caattttctt cataacacct ccaaccaact cctagtatct   1596600
tggataagga taaaattctc ccttttccaa gccaattttt ccttcttcaa agacttcttg   1596660
gttccattcc atgacaaatt cctctgcttc tgggtcttcc aaaaagtcca tgaggacatc   1596720
tagcccaacc tcagcagtat ctttaaggaa aagcgcaaaa taagctaaaa attcacggga   1596780
aaatcctttt ttaggcaggt aaggaataac agtcaaatag tcttcctcat tgactgttga   1596840
cttggcagga ttgtagaaaa ggaccgcttc ctcaaaaaga atgtcatctg atgaaacctc   1596900
tccgtcttca tccaccatct ccacacctgc agcattttgc gcttccaata gaaaactcac   1596960
ttctaccgca tggttgcgtt tgtcccagct aatctcaaag tcaaagggaa agttcttgtc   1597020
caactcttcc tctaaaatat ctaaaaatcc gtatgttgcc attttgtcct ctttctatgc   1597080
gactctttaa tcgccccgat tgctcggaaa tatgctaaaa tagatactac catcttacca   1597140
caaaattatt ttatgtccta attataccat attacctcat ttaaaccctt ggtatcagtg   1597200
attttcttaa aagtctgatt tcttcatttc tcataaaaat caatataaaa agccctcgaa   1597260
agggctaata aatctataaa atcaataggc gagtaactag cacaagtgga cgtgcttttt   1597320
tattgactat taccacgata ccacgcttaa tcttaggctt gaactttctt atctgcaata   1597380
gcgtctgtca aagtctgaga aaagttaagc cccatttctc gtcccaactt atctgcccat   1597440
tttggtatgg tcaaagtctt tttaatgggt tcctgacttc ctaggtattc tgatacatca   1597500
acagatacca tagaaataaa agatttatca aggtcatagg ttgacacgaa atcttcatca   1597560
tctttaaaag gatcattatc aattaaagac aagctattga tatctgatgg ctgaggtaac   1597620
tctccatcac tctctatcaa atctgcaaca gttatcccta gccactccga ccccatagcc   1597680
aaagcctcag aaatcccctc tccttgtgta gctgagtatt caaaatctgg gaaatggaca   1597740
aaataagtcg cttctgttcc gtctgtgtcg tcataataaa ataaagctgg atacgtaact   1597800
aacatttcac tacctccata tcaaaaagca gggactgaat tttacaaccc agcttgcttt   1597860
cttatccctc tttcagtgta cttattcagc tcaccatgaa ggattgtgat aggtctttcc   1597920
ccttgctttt ccattttaat atgggagcct ttaccgcctc tagtctttat ccaaccatgg   1597980
gccgtaagga gtttaaccat ctctttttgt gtcataggca tagcgctttt acctcctgac   1598040
aacaccatta taacacgtgt tacacgtatt gtaaaggagt gatacttatt attctattat   1598100
acataaaagc ccctagatgt ggttctaagg gaagccaatt tattcatacc tatttttcta   1598160
atgagtagta aaaactgctt ctttatcgag caattcatca tctgtatagt caattgtaaa   1598220
agtatctcga tctaagacag attgaggcgg agttgaatga atcataggaa cactgcgtac   1598280
tctatatttt ttatctccaa tttttacaaa ctgatactct tcgaaaatca aattcaaacc   1598340
acgtcaacgt cgccttaccg tactcaagta cagcctgcgg ctagtttcct agtttgctct   1598400
ttgattttca ttgagtatga ttaactctca agtcttcgaa atcaggattt tcaacagtta   1598460
ttacaaggag gcgatttact acttcaaaaa catcaattat tctatttttc atattttttc   1598520
aacccattat tagaatgaac ttcttggtaa gcaaaatcaa gtttagattt aatgttttcg   1598580
tacaaatcta aaatctcttt tggagtatct tcccggaaga aaagttttct tttccctgaa   1598640
ataacttgat cactaagaat ccaatgacga atttgttttg taaaaatcaa aatttcctga   1598700
cttggtagtt ccatcatttc cattgcttat cacctctctt ttcattatag ttcatacaat   1598760
gacattcagc aatattattt ctcaagtcag cacttccact tctttaggct caactatcct   1598820
attttgagct ttaaggaaaa tcaaatctct catgctgata cctctcctca ttaaattaaa   1598880
tagtaaaaaa gattctatct cactccctga ttattacaaa accattgaaa tatcacaact   1598940
aataggctag aatggacata gtaagatata gtagatgagt cattctactc aaatccacgt   1599000
tagaaaggac tgctatgcca gacaatctcg cgcttcgcat gcgccctaaa accatcgacc   1599060
aggtcatcgg tcaggagcat ctggtcggac ctggaaaaat catccgccgc atggtggaag   1599120
ccaaccgctt gtcctccatg attctatatg gccctcctgg aatcggcaaa accagtattg   1599180
cctctgccat cgctggaacg accaagtatg cctttcgaac tttcaatgcg acagttgata   1599240
gtaaaaagcg actgcaagaa atctcggaag aagctaaatt ttctggtggt ctcgtcctat   1599300
tactagacga aattcatcga ctagataaga ccaagcaaga cttcctcttg cctctcttgg   1599360
aaagtggact ggtcatcatg attggagcaa cgactgaaaa tcctttcttc tctgtcactc   1599420
ctgccattcg tagccgagtt caaattttcg agttggaacc tctgtctaac caagacgtca   1599480
aagaggccct gcagatagct ctaagtaacc ctgaacgtgg ttttgatttt ccaatagaac   1599540
tagatgagga tgcgctggat ttcatcgcaa cctctacaaa cggagacctt cgctctgcct   1599600
ttaactcact ggacttagct gttctctcta cccctgagaa tgacgagggc attcgccaca   1599660
tcaccttaga catcatggaa aatagtcttc agagaagcta catcactatg gacaaggatg   1599720
gagacggtca ctatgatgtt ctatctgccc tgcaaaagtc tattcgtggc tcagatgtgg   1599780
atgccagtct ccactatact gcccgcttga ttgaggctgg ggatctgcct agtctcgctc   1599840
gtcgcttgac tgttatcgcc tatgaagata tcggcttagc caatcctgag gcccagattc   1599900
ataccgtgac tgctctggat gctgcccaga agattgggtt cccagaagcc cgcattctca   1599960
tcgccaatgt cgtgattgat ttggcccttt ctccaaaatc caactcagcc tatgtagcta   1600020
tggataaggc acttgctgac ctcaaaacat cagggcactt gcctattccg cgacacctgc   1600080
gtgatgggca ctacagtgga agcaaggaac tggggaatgc ccaagactat ctctatccac   1600140
acaactatcc tggaaattgg gtcaagcaag actatctgcc agaaaaaatt cgtaatcatc   1600200
actatttcca agcagaagat actggtaaat atgaacgggc tttggctcaa agaaaggaag   1600260
ctatcgaccg tttgcgaaaa atctgaaatc cttttcaaaa aattgcactt tcctcttgat   1600320
tttttttgaa aaagtggtat catataaata tagaaacgct gtggtgtacg acttcacact   1600380
taagtgttga ccgactattt tttgtattat tagggaaaca aaagtcttct aacagcatgt   1600440
aggccgtctc acacggaaac agcttcagtt agagcgagtt gcccacctgc ttaattgcgc   1600500
gggttcaata caaaccgtga agtttcggca ccaatacagc ttttttcttt gcctccttag   1600560
ctcagctggc agagcagcgg actcttaatc cgtgggtcac aggttcgatc cctgtagggg   1600620
gcatataaat acaacaggaa aagccttata atatagggct ttttttgctt tccttttaaa   1600680
aattgtcgtg caatttgccg tgtttttaca acaaactttt cacagccata aactcctcac   1600740
taattttttc ctccaaggta tgcccataaa cgtcaatcaa catggagata tctttatgtc   1600800
ctaaaatttg gctctttgtc aactgtagtg ggttgaagtc agctaagctc gagaaaggac   1600860
aaattttgtc ctttcttttt tgatattcag agcgataaaa atccgttttt tgaagttttc   1600920
aaagttccga aaaccaaagg cattgcgctt gataagtttg atgagattat tggtcgcttc   1600980
caatttggcg ttagaatagt gtagttgaag ggcgttgacg attttctctt tgtcctttag   1601040
aaaggtttta aagacagtct gaaaaagagg aggaacctgc tttagattgt cctcaatgag   1601100
tccgaaaaat ttctccggtt ccttattctg aaagtgaaac agcaagagtt gatagagctg   1601160
atagtgatgt ttcaagtctt gtgaatagct caaaagcttg tttaaaatct ctttattggt   1601220
taaatgcata cgaaaagtag ggcgataaaa atgtttatcg ctgagtttac gactatcctg   1601280
ttgtatgagc ttccagtagc gcttgatagc cttgtattca tgagactttc gatccaattg   1601340
attcatgatt tgaacacgca cacgactcat agcacggcta agatgttgta caatgtgaaa   1601400
gcgatccaac acgattttag cacatgggaa aagttgtcta gctaagtcat agtaaggact   1601460
aaacatatcc atagtaataa ttttgacgcg acatcggacg gctctatcat atttaagaaa   1601520
gtgatttcga atgatagctt gtgttcttcc ctcaagaaca gtgatgatat tgagattgtt   1601580
aaaatcttgc gcaatgaagc tcatctttcc ctttgtaaaa gcatactcat cccaagacat   1601640
aatctcagga agacaagaaa aatcatgttt aaagtgaaag tcattgagct tacgaataac   1601700
agttgaagtt gagatggaaa gctgatgggc aatatcagtc atagaaatct tttcaattaa   1601760
cttttgagca attttttggt tgatgatacg agggatttgg tgattcttct tgacgataga   1601820
agtttcagcg accatcattt ttgaacagtg atagcacttg aatcgacgct ttctaaggag   1601880
aattctagta ggcataccag tcgtttcaag ataaggaatt ttagaaggtt tttgaaagtc   1601940
atatttcttc aattggtttc cgcactcagg gcaagatggg gcgtcgtagt ccagtttggc   1602000
gatgatttcc ttgtgtgtat ccttattgat gatgtctaaa atctggatat tagggtcttt   1602060
aatgtctagt aattttgtga taaaatgtaa ttgttccata tgattctttc taatgagttg   1602120
ttttgtcgct tttcattata ggtcatatgg gacttttttt ctacaataaa ataggctcca   1602180
taatatctat agtggattta cccactacaa atattataga acctaaaatt ttcgctataa   1602240
ctcccaaatc aatattatta tgccataaat aactaccata agagtaatac tcaatgaaaa   1602300
tcaaaaagca aactaagaag ctagccacag acagcacttg agtacagcaa ggcgaagctg   1602360
acttggtttg aatttgattt tcgaagagta taaatttaaa taattcaatt tcgatatggc   1602420
ttatattttc tagcaagcgc tcctgcaaga accttgacta aaaatgcata atgcatggta   1602480
ctaaacgata atcccagaac ttctctaata taaaaatata aatctgaatc ttttggcatt   1602540
tcagtttgta caacataaat gtattcaggt gtcgcttctc gagttaaaac catataatta   1602600
ttataattat cgtaaacatc ttttatcaca tcactagtta tggtattaga ggtattcttg   1602660
tggtaatagt aagaatctag acaaattttt ttatcactaa aaagcgcatc tgctaaagaa   1602720
tacccatcag ccttatgata acaactgcaa gcaatattcc agagagccaa catccgactc   1602780
gcataaacta cgtttagatt tttaccccca tacgcttctt taatcaagtt cgcaaatgaa   1602840
gacgcacagc tagcagtaaa accatacctt ccaaccaaat cgggcgacaa cttagccaat   1602900
ctttctaact tttggtcttg aataagctct tcaaatgtat gttgtttcgt tctagaaaca   1602960
atcggttgtt tttgtttcat gatttgtttc tccttttcta taattcaagt taaaatattt   1603020
ttattatacg ttttatacta ttataactgg tggtgctctc aattccattt atctacctct   1603080
ctaacaaata catcattgat taacactttt tagagtaaaa aaatatgttt ttgtattcgt   1603140
ctttgattaa cacataagga cgaaaaaaat ttagaaagat tcctttctaa gcatattata   1603200
ccgaaatcca gataaagtgt caatacttga ttaacacttt tcttgaaatt tttctagtaa   1603260
atcttttttc tttaaaatag aagcaaacaa aactaacttc actacaaatg aaaagaatac   1603320
tctccccttt gtaagctctc tcaactttaa ctgtatatct ctcatacctt catatactaa   1603380
tgtgtctaaa gtcaaagttg ttctcaagct agtggcatct atatccacgc tttcactaat   1603440
ttcacttatc ttaatttttg acttgttcaa ctctacccaa tcaataatat caatctcatg   1603500
tgatatctgg ttataagcaa cttcaatcac atagccatca gaaactggga tatctgaact   1603560
gcctaaataa agccttctaa cttccctcaa tcctaaaacg ctatctctac ttaatttaat   1603620
acctaatctt tcattgttct tcatcagttc ctccaagcaa gtgttaatct ataattaact   1603680
atactatatt ttaaattctt tttcaagcaa taagtcgggc aattgccggg caacgcccca   1603740
ccaacaaact caaaaaactc atttaaacgt tacaaaacac cagaaaatca agaacatcta   1603800
agcaacatat ctcctacaat ccctgtaggg ggcatctaaa tacaacagga aaagccttgg   1603860
aaccaaggtt tttttgctta aataaaattt ttttcaaatt ctttagaaaa ctagcttaaa   1603920
tcataatcca acaccaattt tacaaatacc ataaactaag cttatatacc caaaacacaa   1603980
aaagtcctct ttccactatt ttagaaagag aactttttct ttaggagaaa taacttaatt   1604040
tttaatcaat tcgtgatagc tcagctggca ccgttaagta ataagttgca gtcaagcttg   1604100
cttcaccttg attgacaaaa atctcgatgg aatttttatc tagaacaact tccaattctt   1604160
tagcttcaat atctacatac cgtcgactag tgtcctgttc ttcttcacct agaatttttt   1604220
gaataagatg gctacgatca atgtaaactt gctgcgcatt actgtcataa ccaaattcaa   1604280
gataatctat atcatttcct aagtggtaat gacaatcttt atctatttgg atttgatatt   1604340
ggcctttttt aacagggaat tgtcttagtt tgccatcttc caatcttaga attctaggta   1604400
gagtcatggc acatgcccac ttgtgttctt ggtcatgggt tggaagggta cgcccccatg   1604460
tctgcatcca agcaatcagg atacgacgat tttgatcgtc caacaatgtt tgaggcgcat   1604520
agaagtcttg gccatgatca atttcttgaa ctgattctgg gataaaacgt ttttctctcc   1604580
aatctacctt acccgtgaac aaaagcgatg agttgatgtt atgatatgag tctccctcac   1604640
gctgataacg catgggtgac ataataaggc aatctttccc atctaactcg aagtaatctg   1604700
ggcattccca cataaaacct tggtgttctc ccccttttaa aaagatggat tcgaactgcc   1604760
attctactag gttatcggac cctagtagaa cgatacagcc cacattatcc ttgtgtttgg   1604820
cagctactac ggagtaatag cgtccatctt tttcaaagag ttttggatca cggaaatcag   1604880
cagcaatcaa ctcatctggt aagtctgatc cagttgcaac tggattttgg gaaatctttt   1604940
caaagtgaat cccgtcatct gaaaatacca tattttgcac ttggcggaca ccggtttctt   1605000
cttcgatatg tccagtgtac atgagccaga ggcgatcatc cttgacaatg gcagagcctg   1605060
agaaacaacc atttcggtca taatcttggt caggagcaag tgccactggc aagtgctccc   1605120
aagtcaccaa gtccttactt ttagcatgtc cccagtgcat aggcccccaa acactatcat   1605180
atggatagaa ttgataaaag agatggtatt ctccacgaaa atagacaaat ccatttggat   1605240
cattgatcca accaatctca gctgaaaaat gttcttcagg cttatattga gtattaacga   1605300
gatgtttatt ttctgctata aaacgattgg ctttttctac tgtgtatttc ttatctccca   1605360
taatcaacct ctagtttttg tttgcttggt attggtcgta gtatttttgt ttaatagcga   1605420
ggtaatcaga aagtccgtat ttttcaagtt ctttcttgta atcatcccac tcagtatcaa   1605480
tattgccatt tacaatccat tcagcacgtt tacggtagat atagtcattc atatctgctt   1605540
cgatatgggc aatcttgtcc aaatcttcct gtgtcataaa gactcttgga tagttattga   1605600
cattgctcat gtaaggaaca taatattctt tgataagatc caaacgccat ttggcatcat   1605660
caggcatggt tgttacttta ccatagtatg aatctaggat agctagtggt cctcctactt   1605720
cagtcttttg acgaagttct gctggtgcag ttccgtttag tggtaagtgt tttagactat   1605780
ttgacgcttg atccaattca aagatgtttt gttgtttgtc atctccgtaa gttccccagt   1605840
tattttgcac agattggagt ggagcgtatt gtgcatcaat ccatttagct gtcaattcta   1605900
ggtttttgtt tacactggta ataaccatct tgtcacgtgc aaatcccata ccgtttgtac   1605960
gagctacgtg tttttgacca cttggtccag caagtactgg taaaacatca taactttcgt   1606020
tacttccagt aacattattc ttatcccatg taaagtaaac accaaatttc tgatcatgac   1606080
ctttagcaat gtaactattc caatcatgtt cgaaagcttc tttatcaatc aggccttttt   1606140
cttgcaattg acggataaat ttgacacctt ctttatagtt atcgttatct gctgtgaagt   1606200
caactttgcc atcatttcct actactaaat gatcatcgtt atcccctata ccaaatgcag   1606260
caaataggaa tttaaaatct tcgtttccgt taccactaat aaatgaaaat ggaatttcat   1606320
cagcctctcc atttccattt ggatccccgt ttttgaaagc ttctaggact ttaatcaaat   1606380
catcagtagt ttttggcatt tcaagaccaa gtttcttaag ccaatctttg ttaatccaag   1606440
ccatatcgtt gacactgtga atagactctt taccatctcc aagctcttca atccatggaa   1606500
atgagtaaat gtgcccatca ggtgctgtca tcaaggcctt gtactctggt ttctcatcca   1606560
aaattttctt aagatttggc atgtatttat caatcaaatc ttcaactgga ataataacac   1606620
cttttttagc ccagttcatc aagtccacat ctgaagctcc gtcgttgtgg atagcatctg   1606680
gtaaatcacc actagaaata tccaagttac gtttttctgc aaagtcggat tggtagttgg   1606740
tccagtcaat atgaacgcca gtttccttct ccaaacgttg caaaattaac ttttcatttg   1606800
ggtctttagg agataacggt gaactggctg tcataaactt caatgttttc ttttcttgaa   1606860
gcgggaatgt tacaccttcc aacttataat ctggacttga agctgtattt tttgagccac   1606920
aggctgcaag tactgctaaa ctagctgtca acaaaactgc tgattttgag aatgttttga   1606980
atttcatgag aaaactcctt ttattttttc tttttttatc ctttaagtga accagccata   1607040
attcctttat caaagtattt ttggaagaat ggatacataa caatcaatgg caagctggaa   1607100
atgacaatag ttgcgtattt aatcaattca gctaaacgtt tcatttcatt catagccgct   1607160
tgtgctccaa tcatgtcttg acctggttgg ctctgaatga gaattttacg aagtacaagt   1607220
tgcaatggtt ccaagtttgg atccttgata taaatcattg catcaaagta tgagttccac   1607280
tgtcctacaa aagcataaag gaagagaaca aacataattg gttttgcaag aggaagcatg   1607340
attttgaaga aaatctgtaa atcatttgca ccatcaatga cagcagcttc aactaattct   1607400
tcaggcaatc cttggaaata ggccctagca agaataatat tccaaacgtt aacagcacct   1607460
ggaacaatga tagcccatgg agtattgagc attcccaatt cttttacgag caagtaagtt   1607520
gggactaaac caccaccaaa gaacatagtt acaatcaaga agtagttaat ccaacgacgt   1607580
ccaaccaagt ctttcttaga aagaggataa gctgtaaaca cagatagcaa gactgttaaa   1607640
gctgcaaatc caaaagagta tagtagagaa ttgataaaac ctcttagaat agattggtca   1607700
ctgaatacac gctggtaacc ttctacagtc caatcggctg gattaaagct aatccctcta   1607760
ctaaccagaa ccttaggatc cataaaggat gctacgacga tataaagtaa aggaagcaaa   1607820
gtcatcaaaa cgataaagac aataatgatt ttatttaaga gtaagatacg tctatcaaat   1607880
tttgtatcca taatcgaatt tttcatactt tcctccttaa attccttcac cattattcat   1607940
gcgtttaacg atttggttaa ctgcaacaag caatactacg ttaatcactg cattaaacaa   1608000
accaaccgct gttgagtaag aatagtctcc tgatacaaga ccaactttat agacatatgt   1608060
cgagataatt tcagaagttg gcaaatttaa cgatgtctgc atcaagaatg ctttttcata   1608120
tccgacattc ataattccac ctgcagctaa aacaaattgg ataaccataa taggcttaag   1608180
agctggaata tcaatgtgcc agattcgttg gaagatattg gctccatcca gtcgggctgc   1608240
ttctactaag gctggatcta catttaccaa tgttgccgtg tagagcgttg aagcccagcc   1608300
cattccttgc cagataccac taaagatgta taaaggtcta aagaagtctg gatttgtcaa   1608360
gaagtcagcc ttcattccaa acatagaaag aaaattgttg attggtcctc ccactgaaaa   1608420
gaagaggaaa atcataccga caataacaac gactgagata aagtttggtg cgtataaaat   1608480
gagctgaatt cgttttttga ctttttcact caagagttga ttgagcataa tcgcgagaat   1608540
gattggtggt aaaaagccaa gcaataaacc atagatactt aattttaatg tgttggctaa   1608600
caagatacca aagttgggag aggatatgaa ttttgtaaac tcagaaaaac caatccaatc   1608660
actccctaaa attcctttta aaggattgta atctttaaat gcgattaaaa ccccatacat   1608720
agggatgtat ttaaagataa aggttaaaac taaaccgggg acagtcatca ataacaagag   1608780
tttttgtttc ttgattcttt cccaaagaga aacttgcttc gctttgctat tcatagcaac   1608840
ctcctttttt gaaacgtttc atttttttct agaaaagata gcgcttggcg ctgtctcttt   1608900
atttcttttt ttgaaacgtt tcatttttgt tttaaaaata aatcttttta tctgaattca   1608960
ttctatcatt gatagcgctt tctgtcaaga cttattttca ttttttgttg tttttccttc   1609020
aacaaatttt actggtagga ttgtctgcaa attaacagtc tttccatcaa ttatatcaaa   1609080
caaaatacga accgcttctt ttgccatttc ttccaatggt tgttcaatag ttgaaagtag   1609140
ataatctcta tctccagcca ttttaattcc atcgtatcca ataatttgga catcatgagg   1609200
aatacgtttg ccattttttt ctagtatttc aatcacatcc aaagctgtaa aatcgttgat   1609260
tgtaaaaatt ccatctatag aagaattttc ttccaagaaa ctctctagct ttccataata   1609320
gtcagtaact gtctcatcca aatcaaaaat actaagaggt attttatgct cttggacata   1609380
cttttcaaat gaaattctac gacgtttggt ttcattaatg gttgtattat gtccgcccac   1609440
aaaggctaaa tgctgacatc ctttactaat taattgttta gctgcttctc ttccacctgc   1609500
atcattatct gatgaaacac aaggaatggc aatatctgag tatgtgcggt caatactaac   1609560
aaagggaatt cctgacgtca agtaatgttc aattggacta taggtaatgg caaccactcc   1609620
atcaacttta ttatgacgca acatctccag atagtcttgc tctctatttg taccattgat   1609680
agaacataag agtaatttgt tatttctctt atagacttca ttttccacat gcatagcaaa   1609740
ttctgaaaag aagggatgcc agatacttgg tacaatgatt gcaatcgttt ctgttcgatt   1609800
ttttttcatt cctctagcgt agtaatctgg aatgtaattc aaagttttaa tcgcttgttc   1609860
cacttttttc aaagttactt ctttaatgcc tttttcttta ttaattacac gtgaaacagt   1609920
tccaacacta actcctgctt ctaaagcaac atctttcatg gtaattgatt ttctttgttc   1609980
taccatatta tcacctcctt tcaatatata gtatcatgca aatgcttttt aagcaactat   1610040
ttctcaatca tttttggcca gatcatttat cccatcatga ataaaatcac tccaattagc   1610100
ttttgaaaat acttcaattt tcatgtgtaa acatctacat aaaacaggaa aagccttggt   1610160
ttcatggctt ttttcgtatc ttctataaaa aaagcaagag ttttagatgg ctataaatct   1610220
agatgtacat tttgcttaaa tgattgaagg tcttttctta acaaaaacac ccccaaaatt   1610280
agactttttc tgtctaactt ttgaggtaca gttcaaacgc gaaatagcgt ttttttgtta   1610340
tttttggtta ctcatctaat cgaataaaca tcatggcatt taacaagtat atgagtgaga   1610400
ccgtgtttat attatttgaa tagatgagtc tcttattttc aataggagga ataataaaat   1610460
tagaaataat gatatcataa ggtgaatctt ctaaagattc ctttgataat tctaattcag   1610520
tccaaacttc cagttcaaaa ttattgctac aataataaga aagtgtctct gcaacgaatt   1610580
ttgcatgata ctgatcaaaa ttactcataa ctaaaacctt tagtttaggc tgattttgta   1610640
gcaaattaat caccaaatgt ttggtatgag tgatgaaggt ataagataga tgatttacca   1610700
tcattgaact agaacaaacc tcaagagtct ctaaatagtg agaaagctct ttttttatat   1610760
ctgaaacaaa ttttggaaaa atattttgaa agttcctgat tgtattccct ttttgatcaa   1610820
ataaaataaa ctcagtaaac aactcttgac gatacagatg tgcggtatta tgcagatgcc   1610880
aaatcagatt atccttattc tccatttcaa tctgatactt gactgaaatc tgatcaataa   1610940
aatcactcaa tagatggtaa gatttttcaa cataactatc cttttttacg catttcataa   1611000
agagactttc atctatgaaa aacatttttt gaaagtaaga cacaaataat tggcaaacaa   1611060
cttcttcatc taaagagata ttgtattctg attcaaaact ctgagcaaca ccttctattc   1611120
cttctgcctg cattaaaaaa tccaaacttt ggtcgttaaa agaatcttta tctacttcca   1611180
taaaatgacc aaactttatt ctatataggt tcgtaactag gagcaacttt agcattctat   1611240
gcgttgacaa attcattgga aagcttgttt ccttataaac caattctaac aattgagata   1611300
gtggctctga tgaaaaattt tcaaatggcc attctaggaa ataatatttt tctgaaaaat   1611360
attgtgcaaa aaagtaacga atgtctctct catttccaat gatttgaaca ggggtcagac   1611420
taacttcaaa ttgaaattgc cttttaatca ctttattgat ttggctaata atacgataga   1611480
gcgaagatga actgatataa aattctttac aaatactctc agcttgacaa ccttcattaa   1611540
agaagatgaa ttctaaaatc gaaaaatgag ttgaatgttt aaagaaatga tggtaaacca   1611600
tttcaatatc actatcatcg gtattaataa tgcgtatacc attagtagaa gaatgaaaaa   1611660
tcaagtcagg aaaagcagat ttaacatggg atagatcatc tttgactgca cgttctgtac   1611720
aatttaataa ctctgctagt tcagaacgat gaaaccaacg tttatgttca aataataatt   1611780
ctaataattc taattgccta tgactttttt tagataataa atctctcatg aatatctttc   1611840
tctctttata aattatcgga ttaaacctct tgcaattata ccacaaagaa taggtatagc   1611900
atgatataac gacttttcct aaaatctttt atttcgtata ataacactac ggagacaata   1611960
tataaacaat tttcttattt taccgtctat tgagggcgtg aatacagaat caaattcaag   1612020
tctaaagatt atatttttaa ttttaaaaat tatataatag caacaattaa agaatttgat   1612080
tttttaaaat tatataataa taacaatcga aataattgac ttttctatat taaagttata   1612140
taatagtaat aatcaaagaa attgattttt tgatattaaa ataaaaaagg agggtaggca   1612200
gtgttgtgat caattattgc tggaggtctt attggtctct tggcaggtaa aatcactaaa   1612260
aaagtagttc tatgggaatc atcgcaaatg tattcgctgg tttagtcggg gcatatgcag   1612320
gacaatctct tttaggtagt tggggtccag caatcgctgg aatggctttg ctcccatcta   1612380
ttgtaggtgc agcgattgtg attactgtag tgtcattctt tacaggtaga aagtaaactt   1612440
ttcgccagta aagttagcaa actattttta aatcaatgac gggaaaaata gtttaaatgt   1612500
taaatcgaaa ggattgtata tgtcaaaagc aaagaaaata tgtttcatta ttttctgtat   1612560
tttaatcttg acaattttcc ttcctgtttt gatagattat catcaagtta gtgatctagg   1612620
tattcatcta cttagctgga gacagaactc cgtagttgaa ttctatcttg ctagatatgt   1612680
cttttggggg acagtggttc tatcaacttt agttttatta tccattttag ttgtgatgtt   1612740
ttatcctaaa cgttacttgg aaatccaact tgaaactaaa aacgatacat taaaattaaa   1612800
gaattcggca atcgaaggtt ttgttagaag tttggtgagt gatcatagat tgatcaagaa   1612860
cccaactgtt catgtaaatt tacgaaaaaa taaatgtttc gttcatgtag aaggtaaaat   1612920
tcttccttca gacaacatcg ctgacagatg ccaaataatt caaaatgaaa taactaatgg   1612980
attgaagcag ttttttggta ttgagcgtca agtaaaactt gaagttgcag taaaaaatta   1613040
ccaaccaaaa cctcaaaaca aaaagactgt tagtcgtgtg aagtaaggaa gtaaaaaatg   1613100
gaatggctta aacaatatcg atatccaatt atcgctggtc tcataggcgt atttctggct   1613160
tgtttgattg tctcctttgg cttcttcaaa acaatatttg tattgatttt aggagcactg   1613220
ggagttgcag ctggattata tatcgaaaaa aactatatag ataaataaaa aaataaaaat   1613280
tactaattta attaaaggag tttcatatgt caaacgaaaa aaacacaaac actaacgtag   1613340
aaaagaaaga tgctactgtt gtagctcacg aaatcaaagg ggaacttact tacgaagata   1613400
aagttatcca aaaaatcatt ggtctttcac tagaaaacgt ttcaggtctt ttgggaatcg   1613460
atggtggttt cttctcaaat cttaaagaaa aaatcgttaa cagcgatgac gtaacaagtg   1613520
gtgttaacgt agaagttggt aaaacacaag ttgcagttga cttaaacgtt attgttgagt   1613580
accaaaaaaa tgttccagct ttatattcag aaatcagaga aatcgtatct tcagaagttg   1613640
ctaaaatgac tgacttggaa attgttgaaa tcaacgtaaa cgttgtcgac atcaaaacta   1613700
aagaacagca tgaagcagac tcagtaagcc ttcaagatcg cgtatctgac gttgctgaat   1613760
caacaggaga attcacttca gaacaattcg aaaaagctaa atctggtctt ggatctggtt   1613820
tctcaactgt tcaagaaaaa gttagcgaag gtgtagaagc tgttaaaggt gcagcaaatg   1613880
gtgtagtatc tcacgaaaac actcgtgtaa actaagataa aataaatata acaggagaaa   1613940
ttatcatgtc agtagaagaa aaattaaatc aagctaaagg ttctattaaa gaaggtgttg   1614000
ggaaagccat cggtgatgaa aaaatggaaa aagaaggtgc agctgaaaaa gttgtttcta   1614060
aagtaaaaga agttgccgaa gacgctaaag acgctgtaga aggtgctgta gaaggtgtta   1614120
aaaacatgtt gagtggcgac gataaataag gttaaaagtt actttatctt tttagtaata   1614180
ttagtcaaaa gagtctgagt caagatgatt ctcagaaaac aaaaagctag agattcccaa   1614240
ttgcggaact ctagcttttt aattttgcct ctttctctta ttatatttca gcaggttgtt   1614300
ggccatgagt acgaatccca tgtcaattct cacttgacgc ttacctctca gatgacatct   1614360
cttataaccc aaacaaacct ttatctgccc aaagacagat ttcatatcaa tcttacgttt   1614420
agcgaaaatt tgtctaccct tggaagataa aagtgcctga tattctttag tttttaaaca   1614480
ctggtaacgt tcattcatat acagtctctt ttgaggggct gattcaggtt cataatcgca   1614540
gtcaacattg atttcaaggc tgtttgcttt ctatctcccc tttttcataa tgtataataa   1614600
aatgaaataa taacaggacg aattgatcgg gacagtcaaa tcgatttcta acaatgtttt   1614660
agaagtagag gtgtactatt ctagtttcaa tctactatat tttcgtacag gtgcttcaac   1614720
catttgaacg atttcaaatc cttctttttg gtaaagattc tgagctcttt gatttgcctc   1614780
gaagacattt agagaaatac tgtctatatc tctattttca aatgctaaac taacaaattt   1614840
ccttaaagcc ttgctaccta agccttgctc ctgtttctgg gggttgataa aaaatctccc   1614900
gatatgaaga ttgctgtctt ctagcctgat tttctggata aatcccacaa actcttgttc   1614960
atcaaagatt gaaaagactc cttccaaggc ttgaagtgtc agtagaaaag gaatccttgg   1615020
tcccatccat tgttcttgaa aggatttgcc tagggagttg gaccactggc atacaaattg   1615080
agcgttttct gtgctcacct tttcttcaaa acgaattgtc atcttttcct caccacctta   1615140
tctatgtttc tccattatac tatttctccc attttttacg aatagataag tatgattgat   1615200
ttttattttt ttctcgtcgg gagcattcta gcttcctttc ttggtttggt cattgaccgt   1615260
tttccagagc aatccattat cagttcagcc agtcactgcg attcctgtca gactcccttg   1615320
cgtcccttag atttgattcc gattctctca caggtcttca atcgctttcg ctgtcgctac   1615380
tgcaaagttc gctatcctgt ctggtatgcc ctctttgaat taagcttagg actcctcttt   1615440
ctgctttact cttggggatg gctctccttg gggcaagtcg tcctaatcac cgctggtttg   1615500
accttgggta tctacgactt tcaccatcag gaatatccct tactggtctg gatgactttc   1615560
cagctaatcc taatagcttc ctctggctgg aatctggtca tggtctcctt cctcatactt   1615620
ggaattttgg ctcattttat cgatatccgc atgggtgcag gggatttcct ctttttagct   1615680
tcttgtgctc tcgtctttag cgtaacggag ttactgatct tgattcagtt cgcttctgcg   1615740
acgggtatcc tggcctttct cctgcaaaag aaaaaggaaa gacttccttt cgtgcctttc   1615800
ctcttacttg ctacttgttt gattattttt ggtaagctac tgcttgtctg ataaaatcca   1615860
atttctgcca tatatccttc atgaaattat ttcacagtta aattataaat tatttctttt   1615920
gtacaaaggg atgatgttat caaatcgatc tgttcttcta tcttcttgat actgatcaaa   1615980
aaatttcatt tcgactgaaa atatttcgct tataaactgt aaacgaatac tttgtttaga   1616040
cattatagtc gctagactga ctagatgatt actcaaaacg acgtccagaa tactctttac   1616100
tttgcttggt tttttaacaa aaatttgatc atccaagggt tcaatcattt tgtaaccttt   1616160
ttgcgcaatt tgacgataaa agtaagaatg ttgctttgga gtcaataatc ctaacttaaa   1616220
agctcgatac tctaaagcct gtatcgaaac attcaaatcc gacttcaata aaatataact   1616280
atcaggattg ctgacacgct tgccaaccct ctcttcaaat ttgactaaaa actcttcttt   1616340
tggcaataaa aaacatgatg caaaataatt tgcttcttgc tccaaacgat cgccatcttc   1616400
attcatatct ttatatttat gtaaaagaat atgtcctagc tcatgagcta agtcaaaatt   1616460
tcgacgtaca gatgatttat tcgttcctaa cacaatataa ggtcttccca attttgacca   1616520
tgcgctataa gcatcagctt ggccattaat taatcgttcc acgatataga tgcctgaacg   1616580
ttctaattta taaagcaaat catgattatc ttttgaaata cctaattttt ccctggcata   1616640
aagagccaat tcctcaatgg attctccctt atgataagat tcactcacta cattacttag   1616700
gtcatgaatt ataatattag gtataattac aaaactttca aaataatcaa tcaaactatc   1616760
taccttatgt aaatacatag tttgaatatc tattgttttc cgtgttgcta ggtctgcatt   1616820
tctaaaggca attacagaag aatcaaatcg aatgctctct tcttcctgtt caaaataagt   1616880
taaatcaaca tgaaattggt tggccaaatg cattttggtt gataatttag gtttcgtttc   1616940
gttggactca aactgccaaa tggcttgttc cgttaaatta attctctgag ctaattctgc   1617000
tctacttaaa ccatttaaca gccgtaattc tttcaatacc cgaccattaa acatttacat   1617060
actccttact acttttgacc ttcttgtttt tctattcttg gaataatttc aaaatcttct   1617120
gtttccgata attctgaaaa attaggaata tcttgatatt tagcttcttc gaaatggtac   1617180
gaacttgatt gaatatactc agacaaatct tgaatcaagt gtaactgacc agttcgtgca   1617240
tcaggcataa caacatctac agatataata ttgttttctg agtccgcctc ataagttaaa   1617300
atcataaatt tttcgatatt cgaattttta gtagcttgtt caatttcttg aatcatttca   1617360
tcagaaacta actccatctg aattggaaag gaatgactat tttcatcatt tttgtaggaa   1617420
gaatgttgat taagataaag tgtattcatc tgagcatatt caaataagta gccactctta   1617480
tttttttgta ccaaaggaaa ttggtttgta agtcgcttct taccctttat aattaacaat   1617540
actttcccat atttttctgt atttgtttca aattctaaat atccccaagt ctgtcctgct   1617600
aattgtaatt tatactcaaa caaatctgct gatgcaaatg cagtatcaat atgattaggt   1617660
cgcgtccatg cataaccatt cgacactatc attgtctctc ttttttctag acgttcatct   1617720
acataatctt tttgcccttt catcaaagta tctacaattt tttgtgcctc aagcgaatca   1617780
aagagatcct gattcaacat aattcttcct cctccaaata ctttttaatg aattatacca   1617840
ttttcttaaa gaaattacta caataattat ctttttctta aagttctgtg tcagagtaat   1617900
ttagaaaatt atatcttcta tagtaaaatc aattaaaaac tgaacaaatt tattgggaaa   1617960
ttcaaatcgc tttctgaaaa tattttagga accgtagtgt aatattccag attcaattca   1618020
ctataaaact gacctttctc ctgcaaaaga aaaaggaaag acttcctttc gtgcctttcc   1618080
tcttacttgc tacttgtttg attatttttg gtaagctact gcttgtctga taaaatcctg   1618140
aatcggctct ccttggtgga gagcttttac tattttcgaa ccgacgataa caccatctga   1618200
caccgcattg aagcgttcca gatcggcttg actagataca ccaaaacctg tcaagactgg   1618260
gatgtcggcc acttgatgaa gttgcgccaa gtgcttgtcc aaatctgcac ggtaattgcc   1618320
tgatttccct gtcactccat tgatggcaac ggcatagatg aatccctccg ccccttcaat   1618380
caactctttc tggcgctcaa ttcctgtggt caagcttact aaaggaatca aggcgatatc   1618440
tgtatttgcc aaaaatggtt ctacaaagtt ggcatgttca tgaggcaggt ctgggataat   1618500
caagcccttc acagctgtat cagccagatc tttgacaaag ttctccacac cgtactgaaa   1618560
gagggggttg aagtaggtca tgatgaccag tggaatctct gtttcaatgg ttttcaaggt   1618620
ttcaactaaa gcctgggtag aggtcccgtg ggctaaactg cgcaagccag cttcttcgat   1618680
aacaggtcca tctgcaacag ggtctgaaaa gggaataccc acttcaattg cagagacacc   1618740
caaatcttct aaaaagtgaa ttgtttcagc aagaccgtcc aaacctttct cgtggtcacc   1618800
agccatgata tagggaacaa aaattccttt tccagctgct ttaatagcat ttaatttttc   1618860
tgttagtgtc ttaggcatga gcttctccct tctttgctgc atctgcttcc aagcggtcct   1618920
tgacttgaac cacatccttg tccccacgac ctgataggca gacaatcata gacttttctg   1618980
gtccaagttc tttggccaat ttcaccgcaa aggcgatagc atggctagat tccaaggctg   1619040
ggataatccc ttccacacga gacaagagtt ggaatccttc caaggcttct tcgtctgtca   1619100
cagggacata gctggcacgt ttaatatcgt ggtagtgaga atgctctgga ccgataccag   1619160
gatagtccaa acctgctgag atagagaagg cttcaagaat ttgaccatgg gcatcttgga   1619220
gcacatccat gagggaaccg tgaaggacac ctggacgacc cttggtcaag gtagctgcgt   1619280
ggtgctctgt atccacacca agccctgctg cttcagttcc atacatagct actgactcat   1619340
cttctacaaa gggatggaag agcccgatag cattcgaccc accaccaaca caggctacta   1619400
gggcatctgg cagatctcga cctgtcaagt cacggtactg ttgtttagcc tctcgaccga   1619460
tgacactttg gaagtcacga acgatttctg gaaatggatg aggccccaag gcagaaccaa   1619520
ggatatagtg ggtatcgtcg atattagcca cccatgaacg aagggctgca ttgaccgcat   1619580
ccttgagcac gcgcgaacca tctgttacag cctcgacctt ggctcccaaa agctccatgc   1619640
ggaagacatt gagggcttgg cgtttgacat cttcctcacc catgtagatg gtacattcca   1619700
tgttaaagag ggctgcagca gttgcagttg ccacaccgtg ctgaccagca cccgtttctg   1619760
cgataatttt ctttttaccc atgcgtttgg caagccaaac ttgtcctaag gcattgttaa   1619820
tcttgtgggc tcctgtatgg ttaaggtctt cccgtttgag ataaatcttg gctccgccaa   1619880
tatgctgggt caagtttttt gcgtaataaa gaggagtttc acgtcctacg tactggcgca   1619940
aaagctggtt taattcctct tggaaacttg ggtctgcctg actttcacgg taggccttct   1620000
ccaactccaa aactgctgtc atcaatgttt ctgggacaaa acgtccgccg aattttccgt   1620060
aaaatccatc tttatttggt tcctgatatg ccatgcttta ccctctctat aaatcttcta   1620120
atcttttcat gatctttttg tccatctgtc tccactccgc tcgatacatc tactgcatag   1620180
ggagtaaagt gttgaattgc ttttactaca ttatcttcat taaggccacc tgcgataaag   1620240
aagggctgtg ctagtccagt cgtatccagt tgaccccaat caaagggctg gccacttcct   1620300
gccacagggg catcaaagag tagataatct gcctgagaat tggggacatg cccatttcca   1620360
tctacctgca cagcctgaat actggcacaa ggcaaattct caaataaatc atctgccacc   1620420
tgaccgtgaa cttgaaccaa gtccaagcca actttgtcaa tcgcttccag cagttctacc   1620480
cgacttggtg aaacaaatac tccaaccttt ttcacatctg caggaataag ctttgccaac   1620540
tcagctgcct cttctaaagt cacctgtctt ttactaggtg caaagacaaa accgatatag   1620600
tcggctcctg ctgaaacggc tgtttccacc gcttctttgg tcgatagtcc acaaatttta   1620660
acctttgtca atctgcaact ccttgattct ctgggccaca ttttctgcct gcataagagc   1620720
tgtccctacc aaaattccgt taaagtatgg ggctagtcgt tccgcatcct gccctgtgaa   1620780
aatggcagat tcagaaatgt aatagcgacc ttcctcaaag taaggggcta aatctacact   1620840
ggtctgcaag tcgacctcaa aggtagtcaa gttgcggttg ttgaccccga taatctcagc   1620900
accaagtctg tgggctacct ctagttcagc tagattgtga gtctccacta agacttccag   1620960
accaagctct gtcgcgtagt catacagttc cttgaggcgt tcttcggaca aggctgccac   1621020
aatgagcaag ataactgtcg cacctgcatt gcgagcgcgg atgatttgct tttcatcgat   1621080
gataaagtct ttgttgagcg tcggaatctc tacctgactg gaaatttccc gtagataatc   1621140
caaatgccct ttaaagaaaa cctcatctgt caacaccgaa atcatcactg ctccgttttc   1621200
ttcataagtc tgggcctgtt gcacaatatc cacatcgaga ttgatatctc ccaaactagg   1621260
gctagctttc ttgacctcag cgattacctg caagcggtcc tgatgattct tcaaaaattc   1621320
tgccaagcga taggtctggc gcagaggctg gatttgctcc agcttcatct gctccacctc   1621380
acgcgccttc tgctctaaga ttcgtgctaa aaattcctga ctcatttttg gtactcctgt   1621440
aacagtctga gtttttcaag ggccttgcct ctagcaatca cttgacgggc caaggcaacc   1621500
ccttccttga tgctatcaat cttaccatta gcatagaaac caagaccagc attcaagact   1621560
gtcgtttcca agaatggact tgcttcgttt ttcagaacgc taagcaaaat ttctgcattt   1621620
tcctgagcat tcccaccacg aatatcttcc atagcatagc cttccattcc caaatcctct   1621680
ggagtaaagc ttgacaagct gatttcgcca ttttcaagaa gtgcaatctt ggttgttccg   1621740
ttcaagccag cttcatccaa cccttctggt ccagcaacca cgatggcacg tttgcgaccc   1621800
atatttttca aaacctgagc tgtactttct aggagttctg gacgactaat tccaagaagc   1621860
tgtgtttcta aagccattgg atgaatcagt ggaccagtca agttcataat cgttggaatt   1621920
cccaattcca aacgagctgg catgatgtat ttcatagctg ggtgcatatt tttagcgaag   1621980
agaaagacga ttccagtttt atcaaagacc ttacctagtt cagctggttt gaggtcaaga   1622040
ttgattccca aggcttcgag gacatctgcg gaaccagatt tagaagatat cgagcggtta   1622100
ccgtgtttgg ccatgtgaat accgccacca gccaagacaa aggctgcagt tgtggaaata   1622160
ttaaaactga aagacttgtc cccacctgta ccacagttgt ccatggcatc atgaatctca   1622220
gttggaatat gctgggcatg tcctctcatg acttgggcaa tggctgtgcg ttcttcaggt   1622280
gtttccccct tcatcttaag agctaagagg agagaagcaa tctgcgcttc agttacacgc   1622340
ccagttacga tacgctcaat gacatccgtc atttccacac ctgataaatt ttcaaatttt   1622400
gctagttttt caataatctc tttcatccta gtttcctcac tttacaacct cctcgataaa   1622460
attccgaata gaagacaagc cgtctggcgt tccaatgctc tctggatggt actggaagcc   1622520
ataaatcggt aggtttttat gttgaatccc catgatggct tggtcatcag tcgaacgagc   1622580
tgtcacttca aagtcttctg gcatttcctc aatcaaaata ctgtgataac gcatgaccgc   1622640
acggccatcc tcaatacctt gatacaaaac agatggcgct tcaaagttga tattgctctg   1622700
tttcccatgc atgacttttg gagccaaacc tagcttacca ccaaagactt ctgcaatggc   1622760
ttggtggccc aaacaaatcc caagaatcgg cttcttgcct gcaaaatcac gaatcatgtc   1622820
ttccatcttt ccagcatcaa ctggccaacc aggaccagga gaaaagacca gaccatctgc   1622880
tttttcagct tcttcataca gcttggaatc atcatttctc agaacctgaa cttctgcaaa   1622940
attcccaatg tattgggcca agttataggt aaaagaatca tagttgtcaa tcaataaaat   1623000
catggtctta gttctccaat tctagtcata gattttgctt tgttaatggt ttcttggtat   1623060
tcgttttggg cgatagagtc gtagacaatc cctgccccag cctgcacata ggctctttga   1623120
tttttgagaa tcatggttcg gatggcgatg gccaaatcca tatcacccgt cgcagacaag   1623180
tagccgattg ccccagcgta tactccccgt ttttccgttt ccagttcata gatacgtctc   1623240
atcgctcgaa tctttggtgc tccagaaacg gttccagcag gaagcgttgc tttcaaggca   1623300
tccatggcag tgagttctgg aagcaaacgc cccttgacta cgctggtcaa atgcatgacg   1623360
tagcggaaga gctccacttc catatactta gtgacttgga cactggtcgt ttcagagatg   1623420
cggccaatat cgttacgccc caagtctacc aacattcgat gttctgctgt ttccttctca   1623480
tcagagagga ggtcagtcgc caaggccttg tcttcttcat ccgtagcccc tcttggtcgc   1623540
gtccctgcaa tcggattggt tgtcacgatg ccatttttga cagaaaccaa actttctgga   1623600
ctagctccga tgatttgata atccccaaaa tcatagaaat aaaggtaatt agaaggatta   1623660
gtcacgcgga gatttctgta gaagtcaaat ggatttccag taacttctgc tgaaaaacgc   1623720
tggctgagta cacattggaa catatctccg ttacgaatca agtcacgagc tgtttctacc   1623780
attccctcaa acttatgtgg agcgatatgc ggtttgaagt ctaacggaga tagatccaaa   1623840
tcttcaaatt catttggagc aggaatgcgt aattcctcaa gcacttggtt caaggatttt   1623900
tccaaggcct cttgactgcg ctcactataa agtgcatcct ctatgacatg tatcttctcc   1623960
ttcttgtggt caaagaccat atagctctca tagacaaaga aatgcatgtc tggcgtccca   1624020
attgtatcct cagggatttg accaatttct tcataaagcg aaatcatatc gtaacccaca   1624080
aaaccaatgg ctccaccacc aaaaggtagc tctgagtggt gctgactctt atgaatcact   1624140
tcataaagga aatccaaggg atcccgatca atcacttgac cattttgata gagaacccca   1624200
ttttcaaact taatctcaaa aactggatta taggctagga tagaaaaacg agctgtttcc   1624260
ttgtctctcg gaatactctc taaaataacc ttatgttgcc cctttaagcg catataagcc   1624320
aagattggtg ataagacatc tccatgaatg attcgttcca ttgtaatttc cctttcagtt   1624380
ctacttctag tccgtggtga ctgtatgaaa aatccccacg caaaataact tgcgtgagga   1624440
cgaaattcgc ggtgccacct caattatagg atttctccta tctctcattc ctgtctcaga   1624500
tatctcctgt aacaggctgt gcgataaagg gcactccctt gagaatgatg ttttcttctc   1624560
tcgtttcaga tgaacccaac tttacagctt tctctgcttg ttttcagcaa ccacaagctc   1624620
tctgtgagag aaagaactgt aatttttcca tctattattt tttagcttct agtagtctgc   1624680
aatcgcagct aggtccttgc ctccacgacc agagacattg atgaagagat gttcatctcg   1624740
gtacaccttt atactcttcg aaaatctctt caaaccgcgt caacgtcgcc ttgccgtagg   1624800
tatggttact gacttcgtca gttctatctg caacctcaaa acagtgtttt gagctgactt   1624860
cgtcagttct atccacaacc tcaaaacagt gttttgagct gacttcgtca gttctatcca   1624920
caacctcaaa acagtgtttt gagctgactt cgtcagttct atccacaacc tcaaaacagt   1624980
gttttgagca gcctgcggct agtttcctag tttgctcttt gattttcatt gagtattact   1625040
agcttttttc gtattagtcc agcctttttg tttgctttta gtagtaggca tggagctgta   1625100
gatagaactc aagttcatca aagcgactta aggccctaat aaaagataaa ccaaacgacg   1625160
gatagaaaaa agcccacaca cagaatatac ttccgtgtga gggcgttggt aacgcggtgc   1625220
cacctcaatt ataaagggac tatcccttta catctctgcc ttgtttaaca acaagctgca   1625280
ctgtaaggtg tgcgcaccga attttcattg tttcaaattc attttcaaaa tcagcccact   1625340
ttcactactt ccaaccacct attcacaatc accacaggct ccctgaagat caaaaatagt   1625400
tacttttctg atttgttgaa cttattttaa tactttgttt tttctttgtc aagacttttt   1625460
tacgattttt ttgaaaatat cattcgaata tgaccatgtc ttccttagat cgaacatgaa   1625520
catgtcccac ttcttagaaa ttggatccaa ctcaatagaa actgaatgga ggctaaacag   1625580
aacttatttt agaacactcc atcttttcca ctaggatttt caagaattaa acaatactag   1625640
aaactctgtc tcctaacaaa tttaggagaa acttcaacag atgtgacact ttccccttta   1625700
ataattgcta aaacaccttc tatcatttct ttagccaatt taacataatt gggagcaatt   1625760
gtagacaaag ctggagtata atactgagaa ataggaatat tatcaaatcc aatgatagaa   1625820
atatcatctg gaataagaat tcctttctca tagcacgcac gaatcaagcc ctgaaccttt   1625880
tcatctcctg aaacaaaaat aatgtccgga taattttggg tagtcaagtg ctgcattgca   1625940
taagaataaa ctgaatcaat tgtagataag ccataaatga cttttaaatc cataaagtaa   1626000
tttttatcat tcagaaaaga acgcacacct ctttcacgat ccttattaac atgggattct   1626060
cctcccataa gcaaccacat atttttaaat ttttcttcag ttacagcttt catcatatca   1626120
taagtagctt gaaaattatt attagataca tagactactc cagacgtttg agattcaccg   1626180
aaaacaagaa aaggcatatg gttcttcttt aaatactgaa ttctgatatc atctacactt   1626240
tcataaaaaa caataacacc atctactagg ctacctgtgc ttgatataat tgaattacta   1626300
attgtatcct cctctccaaa gtactcaact atagcattaa caccaaattc tttacacgtc   1626360
cgtaacactt tatctaacag cgtatgaaac caaattaaag gaaaagagtc gatttttttt   1626420
acagaaatca atatatttat agcttctttt ttagttaaat tttttgcata cgcatttgga   1626480
atatacgaca attcctctat aactttttga atcgcttgat aagtttcttc tttaacattt   1626540
actccaccat taataactcg tgaaactgtt tttggagaaa aacctgataa acgtgcaata   1626600
tcataaatag ttaccttttt cccatttata tttttcattt cagtcctcca ttacgaacat   1626660
tctaatatta ctatacaata tttaattttt tttaacaaga gaatttagta aattatttaa   1626720
gatccacaaa ttcacaaaat taattttaca aatattcttc cccttcaaaa aagtttaaat   1626780
tgcatttcac acctttattt ttaagaatgt ttccaacttc acgacaaata aattcatatg   1626840
agaaaaaact gccataaaat tgtagattaa ctttttcagt aaaatgtgta ggatttataa   1626900
aaacatataa tagcctgtca atgtaacatt ttaacataga gttaattttt tctttaaaga   1626960
taacatttgt tatcaactca tcaggaggta aatgaaaggc aaacaccatt tcacaaatat   1627020
cataaaaaga aataaatttg tatacttgta tcaaacaatt attatcaaaa tattctattt   1627080
tacctaaatc aaaattgatt ttataatctt tcataaaaac ctctgagcaa aaatctactc   1627140
aaaaattaga tgattaaaac atctaaaaag caaaaggaca aaaacatctg tccctttgtt   1627200
tactaaattt cagctaattt cttcgacata aataacacct acaatattag caatttcttc   1627260
catcagtcga agatgttcaa atctacctga taattccaga gtaataaatg acgctatttt   1627320
tttgtccgga acatcaaagt attcaattct gtcagaatta acatctccaa acgctgttct   1627380
tgaatcggtc attctgatac cattttctgc acaataaacc aatacacgat tataggcttc   1627440
tgtagattta accactatat acaattcaat cattttagaa cgattttgca gatatttttt   1627500
tagtggttgg aacatggata tcacacccca aacagaaatg gctactaaaa gagctccctc   1627560
ataaaaacct actccaatag ctaatccaat tcctgccgaa gcccaaatgc ctgctgcagt   1627620
tgtcagacct gtaattttct ttttatctgt aataagaatc gttccagcgc ctagaaaacc   1627680
cacacctgat ataacttgag ctcctaatcg tgtaggatct cctgtcccaa atttataaga   1627740
tacgtattca ttcgtcatca taatcaaaca tgcagctaga caaacaatac tataagttcg   1627800
gatgcctgca ggctgggatt tgctccctct ctctaaacca attatactac caatgactac   1627860
tgataaaaca atcctgacaa ctatttcaat atttgataac ccaagactag tggctgtcat   1627920
gattatttcc ttactttacg ccccggtctt tgtgtgaagt ataataccgt tccagaaata   1627980
atcatcagaa caattgtata aacaaatacc agagcttgtg cattagatgt tgctgtttca   1628040
tcacctgcag atcgaatcgt aatacctaat ggttgagcta ggggatggta aaggaataca   1628100
gataagtcga agtcagttaa taaagagtta aagtttaaag caataacaga gagaacaacc   1628160
ggtaaaataa atggaatgat aaccttcatc atagtataaa aaggtgaagc acccatactt   1628220
cttgctgcat cttccatctc atcatcaaca ctaaataaaa tagcacgtac cattctataa   1628280
gaaaatggga tttttacaac tatatatgca ataagtagaa ttaccaaact acctaccaaa   1628340
atctgattca agacaagaaa ttgtggctga ttaaaagtaa ataataaact tactgctaaa   1628400
agtgtacttg gtagtaacca aggaagtaga gcaccatatt caaataagaa atcaaaacga   1628460
gatttatgtt ttctgacaac acgagcaaat acaactgcga gaattgttgc tgttgtcgca   1628520
gcaataatag aataaataaa gctgaccaag aatggagaga atgccgcact attactaaag   1628580
aataagcgat aattttctaa agtaaagttt gataatgtta agttacctgt ttgaattgca   1628640
actggatctg taaatgagta taatactata aaaattagtg gaagcatgaa aactgtgaac   1628700
aatccatatg ctacaatgtg agcaatgata ttccaaggct tagacgcaat tttttgtttt   1628760
ttaagaggcg ctttagtctt agagatagaa atataatttc cacctttttc tatcttattc   1628820
atgatagtaa gcaaaattgt agttgcaata cctaaaataa ttgcaagtag ggcagctaaa   1628880
tcacgagaat tccccatccc tgcaaatgta ataatcattg gatttatagt ttgaaattct   1628940
ttaccaccaa caatcatggg tgctgctact gcagataaac cactaagaaa aaccataata   1629000
gtaagtgcaa atagagttgg aattaaggtt ggtaacacta cttttcggaa aacagtaaat   1629060
ggttttgctc ccatatttcg agcagcctca atagtgtgat agtcaacgct tcgaattgta   1629120
tttgttaaaa acaatgtatg attagcagtt cctgaaaatg tcataatgaa taagactgca   1629180
ccatacccaa taaaccagtt agggtctaaa gaagggataa cattttgtaa aaattttgta   1629240
atcaatccat aaggaccata gacaaattta tatccagtcg ctaaaaccac tcctccataa   1629300
attaaagagg tcatataacc taattttaaa attttagcac ctttaatatc aaagtactct   1629360
gtaaatagaa cacaaagaat acctacgaca ttaactgtaa taatgagtga aaatgctaac   1629420
ttaaaactgt tcataatact ctgaagtgcc ctctgagatt ttagaacacg atgtacagca   1629480
tcaagggaaa attctcctcc ttttacaaat acattcacta ctagatcaaa gtttggataa   1629540
ataataaatg ttactaagaa ccagattaac cctaaacgaa taagccaatc ttttaaattt   1629600
aatttatgac gcatactgca cctccttaaa attgcagaac gtctgatggt gtgataaata   1629660
attccacact ttctccgaca gatctaatag cagcctgact atcaatactt gttacattaa   1629720
gaatctgact ttcagaaact tttattgtat agtgaattgt aactccagaa aactcaacat   1629780
caataattgt cccttttaga ataaaatctt gttcagtttc acgattgaat cgaactttct   1629840
ctaatcgaat gtatcctttt ttatcctcta agaaaacgct tgtatttttc aataatactt   1629900
cgtggactgt ttcatcggtc aaaacattaa tatctccaat aaaatcacat acaaattcag   1629960
tttgagaatt atgataaatc tctactggtg taccgacctg ttcgatgtat ccattgttaa   1630020
agactgcaat tctatcagat aaagtcaagg cttcctcttg atcatgagta acatataaag   1630080
tagtaatacc taactctttt tgaagtcttt tcaactcttt tctcaaatct acacgtaatt   1630140
ttgcgtcaag gtttgacaat ggttcatcta gacaaagaat tttaggttca agaaccagag   1630200
cacgagccaa tgctaccctt tgttgttgac ccccagataa ttctgataca ttacgctgta   1630260
actgttgatc agagatctta atttttgctg ccactgctga tactttagct ttaataacat   1630320
ctggagctac cttcttaact tttaaaccaa atgcaatatt atcaaaaaca gtcatagttg   1630380
gaaatagcgc ataagattga aatacaatac caattccacg cttttcaggt tccaaatgag   1630440
tgacatctgt tccattaact tcaatacttc ctgatgatgg atctagaaaa cctaccaatg   1630500
ctctcaaagt agttgattta ccacatcctg aaggcccaag aaatgtaaaa aattcccctt   1630560
catgtatatc taaattcaga ttatcaattg caacaaaatc accatattta atttgaatat   1630620
tatcaaattt aatcatctca ctaactccct ctattactaa accaaaagcc tctctttatt   1630680
tcttccataa atttagaaat aatagagaga cttggacata aaaattaact cttatttctt   1630740
attgtacgta ttctaattca gctttttcta cccattcatc caaatgcttt ccaacagctt   1630800
cccagtcaat attttgtggt ttcacttgat caacaaattt cttcgtatct tcaggtagat   1630860
ctttgagggc atctttattt gcaggaatag atccaaagtt cttactatat tctacttgaa   1630920
tttctgattg accaaaccaa tcaataaatt ctttagctaa cgcttgtttt ttactagtgc   1630980
ttaaaaccat agtttgttca gttacaaatg gtacaccaat ctcaggagtc ataactttga   1631040
aaacaacatt ttgttctttt tgtccaacta atgcaccaga accccacatc attccatatt   1631100
gtattggatc ttctttgtct aacatcttaa caattgaact ttctcccttt tgaagagtgt   1631160
atgcattttt caaatattct tttgctactt cccaaccttt ttcggaaaca cctaattcac   1631220
ctttatcatc aaggtatcga actaagatac ttgctagaat tgcccgtcct gtacctcctt   1631280
gaagaccaga aattgaatat ttacctttat acttactacc taattcagtc caatctttag   1631340
gcatttcttt tacatcaggc gccccaatta aaactaatgg ttgaacaatc acaggattat   1631400
aataattatc tttatctgat aaagattgat caattttatc taaccattta ggcttgtact   1631460
gtactagtaa tttttgatct ctaattttat ttgaatcaac agcaccaatt ccaaatacca   1631520
tatctgcaac tgcattattc ttctcagcaa taacacggtc tgctaattga gcgccagcga   1631580
tatcaaccat ttttatatta aaaccagctt cttttgcttt agcagttaac caatcaccac   1631640
gaccatttga gactgagttc gaatagataa ctaattcttg acttttatca gctttttctt   1631700
cagatgaaga agcagtcgta gaatttgaac ctccagagca agcagcaagt gtagtaagag   1631760
caactcccgt tgcaagtaca gtagaccaaa ctttcatttt tttcatgata agttctcctt   1631820
ttttattatt ttatttaaat ttttcgtgat atggaacaaa ttgtctcata tcttcaaata   1631880
cagtatagtc aatacggttt acagtaatag ttggaatctt ctctaataaa atttcagtta   1631940
attctgctct gactttagta aactcttctt cctcctcttc ggttagagga atccgaagat   1632000
acccaattga aatatggaat tgatatctat catgattagg gaaacaaaca cctgcttttt   1632060
ctgagacata agtacgaatt tcttctaatc tctttgcaga agcttcatct gcaggttcaa   1632120
ctagtatgtt ttgttttccc atttcagtta tacgcatatg aatttcttca tccaacaatg   1632180
gaaaaatttc aagttgttta gcaaagtaat catgtatttc ctgtaaaggt gtatctagag   1632240
gaagattact gctccaaaac tccgtttcac gattttcatg gcacaacaat tcaattacag   1632300
tcatgtgaat agaattcctt ggagttaaag taaacttatc gataaatggt aattctctat   1632360
aacgtgattg aataatatca acaacttcca tcaaatcttg tttagtataa agatttgcta   1632420
caactgtatt cccagggaaa tgattaaatt ccccattctc tttgaactta atttttgtta   1632480
agtttttcat ataaagacct tcttttttat atttgacatc ggtgtcatca tgtttacatt   1632540
atacaatgaa accgtttcct ttgtcaagca cttgcaaaca tttttttaaa tttatctttc   1632600
attaaatatg catttcatta aaaggttaag taattttttc aaaatacagc actcatatag   1632660
acagtatcat caattatagc cattgggatt ttttgattgc caattccatg tatctctaca   1632720
catgtcttca atcgattttg ttgtcctcca atttaattcc ttatatgctt tgtctgcatt   1632780
tgcataacaa gttgcaacgt ctcctgaacg tcttggaact attttataag gaatagggat   1632840
cttattaaca ctttcaaatg tatttacaag ttgtaataca ctagtgcctt ctcccgagcc   1632900
taggttatag atataaacat ctgttttttc agatactttt tctaaagctt ttatatgtcc   1632960
tattgctaaa tctactacat ggatataatc acgcacacca gtaccatcaa gcgtatcata   1633020
atcatttccg aacacactta gctctgatag cttacctacc gctacttgtg caatataagg   1633080
catcaagttg ttaggaattc ctgagggatc ttccccaatc aaaccagact catgagcacc   1633140
aattggattg aaataacgaa gcaacgcaat actccattct gaatctgcca catgaacatc   1633200
ttttaaaatt tgctcaagca tcactttcgt atacccataa ggatttgtcg cacttgtttg   1633260
catcgtctca attagaggtg actgattgtt aattccatat acagtcgcac ttgaagaaaa   1633320
gacaatcttt ttaacattaa attctgacat cacttcaaca agtgccaatg tactcataat   1633380
attatttttg tagtacatca caggcttttg cacggattct ccgacagctt tataacctgc   1633440
aaaatgaatt gcagcatcaa tcgattcttg ttcaaatacc tttctcaatg cttgtttatc   1633500
acaaacatct aattcgtaaa acacgggacg tattcctgta attgcttcaa tacggtctag   1633560
caccaagatg ctagagttcg aaaggttgtc gacaatgata acttcctttc ctaaatttag   1633620
taattctact acggtatggc taccaatata accagctccg cctgttacca atattgccat   1633680
ctgggtttcc tcctaattaa ttccaaccga cttaacaaat ctcataaacg cttcatgccc   1633740
agacggtgta ttcttataaa ctcctgcatc ttccagaact ctcgcaaaca cttgtcctgc   1633800
ttcgtgttga actacgctat taacctcttc tttattaatg cgaggatatt tttctttcaa   1633860
ttggtcggcc cattctaaat gataatccgc aattgcatta tcctctccta aaagatattt   1633920
tccaacttct tctaactctg gtttcaaacg aggtggtaat atcgcaagtc ccatcacttc   1633980
gattaacccg atattttcct ttttaatatg ttgtacatct tgatgaggat ggaaaacacc   1634040
atctgggtat tgttcagtag tatgattatc tcttagaaca atatctaatt cgtatctccc   1634100
gtccacttta cgagcaatag gagtcaccgt atggtgtggg acatcttcag tcatagcaat   1634160
gatgtctact tctaaatctg aatattctct ccacttattt agaattttag tagctaaatc   1634220
taacaagcga tttttatttt cactttgtaa cctaattact gacattggcc attttacaat   1634280
accagcatta acatcctcaa agtctttaaa acaaaattca ctctcaaatt ttgctttttc   1634340
cattgggaaa atatgtttcc ctccctggta gtggttatga ctaagaatgg agcctcctga   1634400
gataggaaga tcagaatttg aaccagcaaa atatcctggc aaaatatcaa caatctccaa   1634460
taattgttca aatgttttag aggtaatagc cattggtaca tgttgactat tcaaaaatat   1634520
cgcatgctca ttaaagtatg agtagggaga atactggaat ccccatactt cgtcaccaag   1634580
tttcaaccga ataattctat gattcgaacg tgctggataa tttattcgcc cctgatatcc   1634640
ttcattttcc atacatagta aacatttggg ataattagtt gcttttacta atttttcagc   1634700
agcaattgtt tttggatctt tttcgggttt tgacaaattt atcgtaatct ctagctctcc   1634760
gtatttagtt gatgctcgaa actcaatatt cttagcaata gcagaagttt taatataatc   1634820
actatcttta cttaacttat aaaactcttc aactgcttct tgaggtgata tatcatatga   1634880
actccaaaaa atatcattta atcgactagg taaaggaact atgaaattca ttaactctgc   1634940
tcctaaacat tccttttcct cgattaaatc tttaatttta ccgtttttta aggcgatttc   1635000
cactaagtaa tcttttattt gtttcaggtc attttcatcg gaaatgcgat caattccctc   1635060
ctcacctatt aacgctagta ctctattttt cacatatatt ttgtcaattt cattatacat   1635120
tccgtattca attactctat caacaaaatt atcaataatt gttttcatat atttttcttt   1635180
ctaatttatg ttcccatatt ttctatacat tatccattta taaattgctt gcgtagtatg   1635240
agcaatttta tcaaggtgat gaataatatc taaagcacta attacttcag aaacgttccc   1635300
atcatcttca aatatgtaat tcattatttt cttttccata tttatactaa gctcttctat   1635360
ctcattctgt ttttgtataa caaccatatc taaacatcca gattgttcct ctctataaca   1635420
agatatagcc ctattcatat gcagtccgat aacttcatga agtattttta tttttgaaat   1635480
aattttcttc aaaatttcat tattttgaag aatctgtaga ttttttaaaa tttcaacaat   1635540
tctatcccca atacgttcaa tgtcagttga tatttttatt acactaataa ttcttcttaa   1635600
gtcatatgaa acaggatgtt gtaaacaaat taactcatat ccttttttat caatatttag   1635660
aactgactca tttatgatta aatcttcttt aatcaattct actcgttctt catttgataa   1635720
atattcaaat aacttctcat atttatcaag cacagatacc caaatggtct ctaaattatt   1635780
tgataattct ataatttcat tttctaaata taaccttaac atttaggtac ctcttcttaa   1635840
caaagttcaa tagtaacaat taatatttta aacaatatat caaacatcaa tgactagaat   1635900
acttgcatca tccttctttc catagattgg atcaatagca gaagaattaa atctcatctt   1635960
aattaactct tcaaaagttt tattttgatt attttgatag aattcataaa agccatcgct   1636020
cattaaaaca atttgttcac tagtaacatc tatttgatta ataatagcat ggtctaaaaa   1636080
tctctcatcc aacgaaccta tccagtaccc actcggttga ttagataatt ttctgatttt   1636140
ttgtaaaata atttttttat ttaaaacact atttgtacca attgaatctt ttatctcatt   1636200
tttccctttt tcaaataagt tatctactct atgatcagtt atttccattt cgtttactaa   1636260
catgacgcag tcacctagca tcatatactc caactttttt tctgaaagtt tagcaaatat   1636320
tggtaagcga taatatagta tattgaaact agaatagtac acctctactt ctaaaacatt   1636380
gttagaaatc gatttgactg tcctgattga tttgtcctat tattatttca ttttactata   1636440
ctctgttaat ttatatgagt ttaaaccgat ttcatcttta acctcgagta aagcagtttc   1636500
aaatatttgt ttaagagttt ttgattcttt acaattaacc gacaaacttt ctgataaaat   1636560
atgtacaact tctgagactg aataacctat ctcctcttta gaattatata aatctgtagc   1636620
tccaccaata atccaaaaat actgattttg tgaacctaca atatcctcat tttctacgga   1636680
acttccttgt atcgaacaaa ttttatttat ctttaccata atacttcaac ccttttagtg   1636740
tcaaaagtaa accaattcct gtcactgtta agaatagttc cataatctta ttcgaaccag   1636800
tctttggtaa tttttgtttt acatctacta tttctttaga tttattaata tgattttcag   1636860
tttctctgcc atctccaact attttatagt ttacttcttc tgtcttatta tcttgtttat   1636920
tgtcgatctt gtcattcatt tgtctattat ctttacttga gttaaactct ccgttcttct   1636980
ggttactatc aattacatta tttgaattag attgtttttc ctctttgttt ttttcttttt   1637040
cgtttttatc acttaaatta tttgttacaa ttttgtaaag cccattctcc gttacaatat   1637100
tgaaattacc atcgctatca cgtataacag gttctttccc atttgcatta gatttgatga   1637160
atgatatata cttaccggat aaattataaa attggttatt taaaacggtt attttaccct   1637220
ttgaatcctc aataacaatt ccttctttac ccccgaatat actattctct gagactacta   1637280
aattatcact aactcgtaat aattcaatat ttggttgttc tgtttcctta gaattattat   1637340
taattacatt ttttgttaca gtaatatctg atacttttcc taaatattct gcactatctt   1637400
ttgcaactcg tatcgctttt gttttaggat cggcaatatt aaatatattt tcggcgataa   1637460
ccacctgttt atttaaatct aataggtctt tagtgttttt atagctataa gcatttacta   1637520
aagctgctcc gctttctcga taatgtacac tctctccttt aactttctta tcaaagcgat   1637580
ttcctttgat taatacatca gtgaatcctg taaaacgtac acctgcatac atcatgttat   1637640
caaaatgatt attttgaatt ttaatattag aggggttctg tgtcgacaat gtttgatagt   1637700
gtgtgccaat tgctgttact aattccccag atttatcact tttgccaaaa taggaatttt   1637760
gaatagtcac attttcagat tttttcccat catcattcaa ggcataagga aaaccttttc   1637820
tagttaatgg ttcaatctga atgctctcct tacttatgat ttgcccatcc ttcatcgttt   1637880
tgggtaaggc ttgcccaaga aaacgagaat tatcaactaa tacatttttc gaacctgcaa   1637940
tttgaatagc atgcccttga taactatcct tgaatgttac attttttata gttacgttat   1638000
ttgaattccc aatagcaaat gcacctgaag aatttataag tggtagattt tttgctttag   1638060
ttccttcttc attcaaagca ccgttcatat caatcgtacc accagaataa ctaatatctt   1638120
ctgttgggcc ccattctact tgcgcaccat catccgtaaa taaacctgtc ataaaaacaa   1638180
tggaagggtg attcttaata tttataccat ttagaattgt agctttctca ttcaattcta   1638240
agtgtgtatg actttttaaa aaaacaattt cttttactaa ataagttcct tcaggaaaat   1638300
atacatttcc tccacctagc ccttgagctg cagcatctat tgcatcttga attgcttgtc   1638360
gatcatcatg aatcccatca cctaccgcac cataatcttt tacacttaaa gcagtatctt   1638420
caaattcttt tttgataatt ctgtcactta taacatcttc cttataactc ttattttcat   1638480
tagtagatgt tactgtagat tcaactgttc tgttgtctaa ttgtgaattg gaacgaatag   1638540
taccattaga gctgatacta ttaacactta acgaattatc taaaccatta gtggttgaat   1638600
tagaggcaat catttcagca gaacgattct gattaacagt tggtgaatta tctaaatcat   1638660
tagtaattgc attagaagac tcttttgtag ccatcggtga agaactagta acaacttcat   1638720
ccgataaaat accttggctt cccaaaattg aaattgccaa tagtaccgag caagtcccca   1638780
cctttaattt acgaatactg aatacctcat taggaacaaa atatttcatc agaacctcca   1638840
atttttttac tatttttaac aattgattat tacttttctt aaaatagata gaatgacacc   1638900
gctgtcatta tctttatcat atattttcca aattgaattg tcaaggaata acacaagaaa   1638960
atattaaaat ttatactctt cggaaatctc ttcaaactag gtcagtgccg ccttgcccta   1639020
agtctaggtt actgacttgg tcagttctat agtagactga aactaaaata gtacacctct   1639080
acttctaaaa cattgttaga aatcgatttg actgtcccga tcaatttgtc ctattctcat   1639140
ttcattttac tatatctaca acctcaaagc agggttttga gctatctatg gccaacttcc   1639200
tagtttgctc tttagccttc cattcaaaag tgatgctatc tttcttagct tgaatataaa   1639260
atatcccatt tactatattt aaatttgttg atatgttgta aattataaat gaaagaacaa   1639320
ataccttgtc atacaagcat tcgccaggga tatttacctg aatatcgctc atatggcgga   1639380
ttgaaactaa aacactacaa tatatttctt aaatagacct tctataaaag ctagatttaa   1639440
cctcgataaa aatagatgca gtgcttctaa aatactggaa tagggcatat aggtaatcgt   1639500
agacaagtgt tttatagatt gtctcgcagg agatctaata atgtatagca agcatcacta   1639560
aacatataga atatttgtat tattataata tcaacatgct ataaattcta tcatgcaaaa   1639620
gaatgactag aacatgaaag acaggcacaa aattttgaac aatattctga aaacaaaaaa   1639680
agacgcgagt ttccacaatc tcactcatgg aaactcacgt ctttcaaaaa atagggtgaa   1639740
ttgaaaacta gaacaagaca ctagattttc taaatgatgt ctagtaagga ttctaaatgc   1639800
tacactaaat tgctcacatc ttatttcaaa ccacgggact cccacaagaa aggaaaatcc   1639860
tataaaaatt ctctctctga ggagaaaggg gcctcaacta caggtgtaaa ctattatcaa   1639920
ttgaaaacaa cagtttttac actcaattag actttttagg ggcaggatca ctttcgcttg   1639980
actgtagttt gtcatttttt tgataaagtt agcacttttt cagaaactgt tttgaaagtc   1640040
tcaatgatat agtctacttc ttcatcgctt aatttagtat gaagagggag ggtaatttca   1640100
ttctcaaaga aggcataggc cttaggatag ttcgtcatat caaatccaag attcttatag   1640160
gctgtcaaga gaggaagcgg tttgtagtga acattacttg caattcctgc tttagccaat   1640220
tcttggatga tgaggttgcg ttcttctagg cttgctcctt ctacacgggt gatgtagagg   1640280
tggcgtgaag attcgacagt ttcagtcttg tgtgccaaag gatggatgcg agaacctgca   1640340
aaaccactat catagcggtc cacaatgtcc ttacggcgtt gcaacaaact tggatagcgg   1640400
tccaattgta ccaaaccaag tgaagccatg atatcggtca tgttgcactt ataggctggt   1640460
gtaacgatat cgtattccca tgaccccagt tgcatcttgg caagagcatc cttagtttgc   1640520
ccgtgaaggg aaaggatttg gaattccttg tacatctctt cgtcatcaat cactggattg   1640580
gctttccaag tcgcacttcc accttctgcc gttgtaaagt tcttaactgc atggaatgag   1640640
aaggaagtaa agtcagcgat agaaccagaa ggttgtcctt tataaataga tcccaaagcg   1640700
tgggcactat cagagacaat gacaatacgg ttaaaggcct tttgccactt gcttgaagcg   1640760
gtaaagaagt cacgtttttt ctccacgact tggaacaaac ggtcataatc gcaaacaatc   1640820
cctgcgagct ctactggaat aatcacctta gttttctcag tgatagcttg ctcaagcagg   1640880
tcatagtcca tctcaaacgt atctgcttgg atatccacca tgacaggggt tgctcccacg   1640940
tgcgtaatga cactacatga agccgtatag gtcatggctg gaacgatgac ttcatcacca   1641000
ggtcccactt ccaaaacgcg taaaatcaac tccagagcgg ctgtcgcaga gttgagacaa   1641060
acagtcttag gtgtctgtgt gtaaagagac aagcggcgct ccagttcttt tgttttagga   1641120
cctgttgtga tccaaccaga acgcagggta tccactactt cagtaatttc tgcttctgtg   1641180
atatcaggcg gtgaaaatgg aatattgtaa tttggcattg atttgctcct tttatctgta   1641240
ctcattttct tatgactact ttattttagt acctcaaaca cggtttgaaa catgattttg   1641300
atgtccccaa agaaactaaa ctctcggaga taggcgaggt tatagcgcat cttttcagga   1641360
agaacatgct ccacataggc ctgatcaact gacagacctt tctccgtcat ttgactgata   1641420
attgtgtcct catccttgta gttgatgctg gctggagagg taatccctgc ttgcaagagc   1641480
aaggttgcca tcatttcagg gctatactgc tctgtataac gtggcacttc aggtcgtgta   1641540
ccgacaaagg acatctcacc tttaaggaca ttgaccaact gaggcagttc gtccaaacgg   1641600
acacgtcgga tgaaatttcc aaccttggta atgcggctat cgttagcaga agtcaccaga   1641660
cttccttttt tatccgcatc cgtcaccatg gtacgaaact tccaaatctt gaaccgacgg   1641720
ttgtactggg tcacacgctc ttgcttgtaa atcactggcc ctttgctatc caacttgatc   1641780
caaatgctca agatgagaaa gatgggagag gtcagaacca gtaagaccaa ggccaaaacc   1641840
cagtccaagc aacgcttgaa aatcagcgaa cccttccttt tagagacaag ctggtagtaa   1641900
gactcaacct cgcttgattt catttccaca ggcaagtctt cccatttcag catgctgttc   1641960
tcctttgttt ttattatact atttgtcaac atttttcatt ataccacaaa atggaaaagg   1642020
cggtgaaaga aatctgtaat ttgaaggatt tccttctagt actcaatgaa aatcaaagta   1642080
cagctttgag attgcagata aagctgacat ggtttaaaga gattttcaaa gagtatcggc   1642140
catggcccct gcctgcaaac tatacatctt gtgataggtt cctcccagag ccaagagttc   1642200
ctcatgggtt ccactctcga taatgcgtcc cttatccaag acatagatgc agttggcatc   1642260
ttgaatagta gaaaggcggt gagcgatagc aatagttgtt cggccctgtc tcatcttcgc   1642320
cagagaagct tgaaccaagc tttctgtttc agagtcaata ttggctgtcg cttcatccaa   1642380
aatcaggatt ttaggctggc tggcgactgt tctagcaaag gcaagaagct ggcgttgccc   1642440
agtagagaag ctcgaaccac gctcggaaac aggggagtcg tacccctgag gaagttcttg   1642500
aataaaggaa tctgcatcca caaaggctgc cgcagcctga acctgctcat cactggtttc   1642560
ttggtacatg gcgatattgg acttaatagt tccatgatag aggaagggtt cctgcaagac   1642620
caaaccgatg ttttttctca gctcttcttg actgaaatcc ctgatatcca catcatccaa   1642680
gagaactctc cctgactgga attcataaaa gcgcatgagg acattgataa tagacgattt   1642740
ccctgaacct gtatgaccta caaaggcaat ggtttcaccc ttattaacag agaaagaaat   1642800
gtcatccaga atcggatgtt taccgtcata tgagaaacac acatgttcaa aacggatatt   1642860
gccttcttgg actttggctt gcccattttc ttgaagaggt tcataggtcc tctcgtctat   1642920
cagggcaaag acacgacctg cagaaaccat agccgtttgc agagttgaaa agttttgcgt   1642980
cacctcaatc aaggggtcaa aaaggcggtt gatgtactgg ataaaggcat acatggtccc   1643040
gaccgttatc ccgatagaaa aaccacggta gccaaagtag gccatcaaga ctgcatagcc   1643100
tagaagtttc agcaaactca tggcaggtct caaaaagagg gcatccaagg ctacagaacg   1643160
gttggcgtag accaagtgtt cttggttgat ttcatcaaat tctgcctgca ggcgcttctc   1643220
ttgattaaag gcctgaataa tcctgattcc ctcgatattc tctgccagct tactattgat   1643280
atctgacaag agacttctgg ttttctcgat gattttcact gacttttttc gatagagatt   1643340
gaccaaaagg aaaatcaaag gaagaaagag caagactaaa gccgtcaaac gaaaatccag   1643400
caccaacatg gtataaaggg ttgtcagaaa gataaaaact gctgagataa agctggataa   1643460
aatcccagaa aacatatcac taatcgtctc ggtatcgttg gtcaaacgag aaacgataga   1643520
acctgctggc gtcttgtcaa agtaagacat gcccagtttc tccatattgg caaaggcatc   1643580
ccgacgaata tccctaacaa tactgtaaga cacgcgcgca aagagaagat tgccgacata   1643640
ctgaactaca gtttgtagga tgtagagacc atagtagacc agcaaaacgg taacggctag   1643700
ttggttaaga ttgctgagat actggtcgat aaagtgggaa gccacgaggg gtatgacact   1643760
tttaatgacc gtcgtcgcta ggagaaaact gagtgccaaa aaggtcagga gtccataagg   1643820
cttgagataa gacatcaagc gcttcaatac agtccattgt tcttgtttat tctgcatctt   1643880
cttctccttt catttccaac tgctgagact ggtaggtttg ggcataccag ccatccaaag   1643940
ctagcaagtc ttcgtgcgtg cctcgttcga taatttgacc attttgtaga actaaaataa   1644000
aatctgcatg gacaacagca ctgaggcgat gggcagtgat aatggttgtc ttgtcctttc   1644060
gcatctcctt gaggttgtcg ataatcgcat actctgtctt ggcatctacg gcggataagg   1644120
aatcatccaa aatcaagata tcagggtcta aaatcatagc ccgactcata gccaaccgtt   1644180
gcttttgacc accagaaaga ctgactcctt tttcaccaat cagcgtatca aatccttgag   1644240
gcatgtctac aatatcttgg taaacccggg ctagcttagt agcttcctcg accgctgaaa   1644300
ggggcaagtt aggattgcca aagcggatat tgtctaggat tgaagtcgca aaaagaaact   1644360
ggtcctgagg aacatagccc atgagactgc gaaggtctgt cagacgatag tcccgaatat   1644420
cgtgaccgtt tagataaatg gcacccttat ccacatcgta ttcacgcaag aggagcttga   1644480
ttaaggacgt tttcccagag cctgtctgcc caaccaagcc cagtgtttgc ccttttgcca   1644540
aactaaagtg aatatccgtc agtgtttcct cattttcaaa agcaaagctg tcaatggcat   1644600
actccaaacg cccattttca ataccatcca gaggaaactc agggtcttgt acaggagatt   1644660
cctgagacaa aagattttca atccgctggt aagaaacctt ccctcgctga gtagtattaa   1644720
agaggaaacc gatggccaga agaggccaga ccagcatatc caaatagctg ataaaggtga   1644780
ctagattccc aactgtaatc tgcccttcct gaaccatcaa ggagccaacc aaaagcgtta   1644840
aaacatagga cgaaccaaca aacaagagaa ccatagggtc aaagagacta tcatatttca   1644900
tggtttgcag gttcttttgg aaggttaatt cattgactgc ctgaaaagac ttcaactcgt   1644960
ctgcctgata accgaaagac ttggtcactt tgatacctga tacggactcc tgtaccttgt   1645020
tattgagttc agaaaaagca gcttgggatt cgccaaaggc cttatgagtc tttctcccta   1645080
ggcgactagt cgtataggcc atgaaaggta gggggagaat ggcaacaaga gtcatctgcc   1645140
atgagatgct aaagagcatg gtcaacaaag tcaccagagc cgtgatagag gcatccaccg   1645200
cagacatgac accgccacct gctaaacgag tcaaggcatt gatatcattg gttgcgtgtg   1645260
ccatcagatc acccgtccga taggtttgat aaaaggctga cgacattttt gtgaaatgct   1645320
taaacaagcg agaccgcatg atctgtccca agcaataaga ggtcccaagg atatacatac   1645380
gccacacata gcgcaaatag tacataccaa aggctgcaag tagcaagtaa aataggctaa   1645440
gaaggaggtc ctgctgggtt aattgccccg atgtgatggc atcaatgacc cgccccataa   1645500
ccataggagg aatgagattg aggacggaaa ccaagatcag ggccacaatt ccgactagat   1645560
aacggcgttt ttctaacttg aaaaaccacc aaagtttttg aataatggac ataaaatccc   1645620
tttctgattg caaatggaaa cctgaggcca atactcaatg aaaatcaaag agcaaactag   1645680
gaaactagcc gcaggctgct caaagcactg ctttgaggtt gtagatagaa ctgacgaagt   1645740
cagtaaccta catacggcaa ggcgacgttg acgcggtttg aagagatttt cgaagagtac   1645800
aagaccccag gtttttctta ttcataagtt acgactgtaa cagcaccctt gtcatattca   1645860
gcaataaaga tattggctac attgtcatgc ccttgtttac tgaggttatc aagcaaccac   1645920
tcttcgctac gaccaatcga ttccaagaca tctacttgaa tcacaccgtc agtcacaact   1645980
ggatacttag gattttcatc tcccatttgc acaacgatga gttgcccatt ttgctcttgc   1646040
acagctcgtt tgacttgctt catctggaaa atcccttggc tacgaagttt gagggataca   1646100
tccgatgcag acaaaccaac tgaacgacag gcttctgggt caatattccc atttttgata   1646160
aggagagttg gcttaccatc aatcaaacgt ttcacaaagt gaacattgtt gttgagctat   1646220
ttgagagtca agaccagttt gattaaaatt tcgatataat taagtgtcat ttgttcacat   1646280
ccaccagttc aattgcgtct gtcttataca attcgacttt ctctaacagg tacttgtctg   1646340
gctcacttcc atttagggca cgataatagc gatctcccac cttgataagt gcgccatctg   1646400
tgtttgtgga agtattaaca tagacttctg acttgtctac tcacaaatct ttggaaacaa   1646460
cctcgatgaa atgaagtgaa gtttgaaatt tattgttaga aacttgattg ttttgataag   1646520
tcgtgatgct gaccaaaagc agagctaaat aaggccagat ctgaaatcat gaccaactca   1646580
cgaaattcgc ttcccttttt attatggtat gccttgaaag caaaaaaaac tgtcacagct   1646640
aatagaacaa tcccaaagcc aaccatgata ccattttgct gaccgatttg gctgagtaca   1646700
tagtcataag agtagaattt catgtatttt cactcccttt cataaaatca ttcttaatta   1646760
taaacgaaag agagtaattt ttcaaaccat acgttgggga aatagatctt tttttggtat   1646820
aataaaatct ataatctgaa tgaaaaaggt aactttatga aacttatctc atggaatatt   1646880
gattccctaa acgctgccct aactagtgac tcagctcgtg ccaaattgtc ccaagaagtc   1646940
ctacaaacct tggtcgctga aaatgctgat atcattgcta tccaagaaac caagctttct   1647000
gccaaaggac ctacaaagaa acacgtggaa attttagaag aactcttccc aggctacgaa   1647060
aacacgtggc gctcttccca agagcctgcc cgtaaaggct atgctggaac catgttcctt   1647120
tataagaaag aacttacacc tactatcagc ttcccagaaa tcggtgcccc ttctaccatg   1647180
gacttggaag gtcgtatcat cactctagaa tttgatgcat ttttcgtaac ccaagtttac   1647240
actccaaacg ctggtgacgg tctcaaacgc ttggaagaac gccaagtctg ggatgccaaa   1647300
tatgctgagt atttggctga actagacaaa gaaaaaccag tccttgcgac cggtgactac   1647360
aacgtagccc acaatgaaat cgaccttgca aatcctgcta gcaaccgccg ttcacctgga   1647420
tttactgacg aggaacgtgc tggatttacc aaccttttgg caactggatt tacagacacc   1647480
ttccgccatg ttcatggcga tgttcctgaa cgctacactt ggtgggcaca acgcagcaaa   1647540
acttctaaaa tcaacaatac aggctggaga atcgactact ggctcacaag taaccgtatc   1647600
gctgacaagg tcactaaatc tgatatgatt gactcaggtg ctcgccaaga ccatacaccg   1647660
attgtcttgg aaattgactt gtaaggattt tctatatgga ctacaatgcg gtcattcccg   1647720
agttgcttgt atcgaatatc gaacagtccc ggtccttcta ctgtggttta ctgggtttta   1647780
ggattgaata ccaacgtcca gaagaaaact ttctctttct cttgaagagt gtcaactaat   1647840
gttagaggag ggaacaaagg atcaactagc tgaactgacc tatccctttg gtcgtggagt   1647900
caatctctcc tttggcataa aggatgtttc aaaactctat taaagagtga tgaaggcaaa   1647960
ctatcctatt tatcgtccct tgaccaaaag aaagtttcgt gtcagtgatc cctatatcta   1648020
tcctcataaa tttgcagttt tggatccaga tggctatttt ttaagattta gcgagtagaa   1648080
taataaaaat tgggaaaagt ctttaaagtt agaaaaaggc atattgtcag gtgtctaaaa   1648140
gcttgatagt atgcctttta tgatggaaaa atcttctaat actcttcgaa aatctcttca   1648200
agccacgtca acgtcgcctt accgtaggta tatgatactg gctctgtcaa ttctatccac   1648260
aacctcaaaa cagtgttttg aggttgtgga tagcttccta gtttgctctt tgattttcat   1648320
ttagtataac tgttagctta caatggagtt tttgttcacc ctctcttctt tttgttcgtt   1648380
ttttaaacca aaacactaac aaaatagttg atttctaaag ttatttagtg taaaataaaa   1648440
acattggctc aagcctattt aaaattgaat atcgttttac ttgtttatgt cgtgaattgg   1648500
cacgacgttt ctacaaggtg ccggaacacc taacaataag taagtcagca gtgagatatg   1648560
gccgtttttg ccatgtctat ttaggggact tacttagaga ttaagtaggt ctttttttaa   1648620
tatttccctt aattagtgcg gacgggaggt gaaattatcc tgtgaataat ttcaggaatc   1648680
cagggaattt catccctaat ttttgagccc ctagctcttt catttctagg cttaggctaa   1648740
aatagttccc cgaactattt tactctcaaa aatcccgtca tagacaataa caagattatt   1648800
gtctatgata ccactacaac gggaaatatt tgataagact cgcttcgctc gtaatagttt   1648860
tatcaaatat atagtattag caaaagggat cactatagaa atatttaaac aacaagtaaa   1648920
ttaactttta gactttagga ggtcttatga aattattaga agagcgcatc ctcaaggatg   1648980
ggcatatctt gggtgataac atcctcaagg tagattcctt tttaacccac caagttgact   1649040
ttagcttgat gcgagagatt ggtaaggttt ttgcggaaaa atttgctact actggcatta   1649100
ccaaggtcgt aaccattgaa gcgtcgggta ttgccccagc cgtttttaca gctgaagcct   1649160
taaacgttcc catgattttc gccaaaaaag ctaagaacat caccatgaac gaaggcatct   1649220
taactgctca agtctactcc tttaccaagc aggtgaccag caccgtttct atcgctgaaa   1649280
aattcctctc accagaggac aaggttttga ttatcgacga tttccttgct aatggccaag   1649340
ctgctaaagg cttgattcaa atcatcgaac aggccggtgc cacagtccaa gctatcggta   1649400
tcgtgattga gaaatccttc caagatggtc gtgatttgct tgaaaaagca ggctaccctg   1649460
tcctatcact tgctcgtttg gattgttttg aaaatggtca agtcgtattt aaggaggcag   1649520
atctctaatg caaactcaag aaaaacactc gcaagcagcc gttcttggct tgcagcactt   1649580
actagccatg tactcaggat ctatcctggt tcccatcatg attgcgacag cccttggcta   1649640
ttcagctgag cagttgacct acctgatttc tacagatatc ttcatgtgtg gggtggcaac   1649700
cttcctccaa ctccaactca acaaatactt tgggattgga ctcccagtcg ttcttggagt   1649760
tgcattccag tcggtcgctc ccttgattat gattgggcaa agccatggta gtggcgctat   1649820
gtttggtgcc cttatcgcat ctgggattta cgtggttctt gtttcaggca tcttctcaaa   1649880
agtagccaat ctcttcccat ctatcgtaac aggatctgtt attaccacga ttggtttaac   1649940
cttgatccct gtcgctattg gaaatatggg aaataacgtt ccagagccaa ctggtcaaag   1650000
tctcttgctt gcagctatta ctgttctgat tatcctcttg atcaacatct ttaccaaagg   1650060
atttatcaag tctatctcta ttttgattgg tctggttgtt ggaactgcca ttgctgctac   1650120
tatgggcttg gtggacttct ctcctgttgc ggtagctcca cttgtccatg tcccaactcc   1650180
actctacttt gggatgccaa cctttgaaat ctcatctatt gtcatgatgt gtatcatcgc   1650240
aacggtgtct atggttgagt caactggtgt ttatctggcc ttgtctgata tcacaaagga   1650300
tccaatcgac agcacgcgcc ttcgcaacgg ataccgcgca gaaggtttgg ccgtacttct   1650360
cggaggaatc tttaacacct tcccttacac cggattttca caaaacgttg gtttggttaa   1650420
attgtcaggc atcaaaaaac gcctgccaat ctactacgca gctggtttcc tggttctcct   1650480
tggactgctt cctaagtttg gcgcccttgc ccaaatcatt ccaagctccg tcctcggtgg   1650540
tgccatgctg gtaatgtttg gttttgtatc aattcaaggg atgcaaatcc tcgcccgtgt   1650600
tgactttgct aacaatgaac acaacttcct tatcgcagct gtttcaatcg ctgcaggtgt   1650660
cggtctcaac aacagtaatc tctttgtcag catgccgaca gccttccaaa tgttcttctc   1650720
aaacggaatc gtcgtagcca gcctactcgc tattgtcctc aatgccgtat taaatcataa   1650780
aaagaaataa gaaaaagagg tgcgagcctc ttttttgttg acaaaataaa aacatctacc   1650840
tattcatata tgctagtgtc atagtcctga aaatcatctg catcaagaac aatttcacaa   1650900
ctcttatact tttctcttac aagtcgttcg gcttcatctg gattttcagc ctctatactt   1650960
actaaacgtg ataaagtttc tgtaatttct actgtatact ttttcagttt tagattgctt   1651020
tccaataatt cacctattaa caataatcta tgataggagc tatgtagcca ctctggcaat   1651080
ttatctccta cttcccaccc atatttttcc ttcatcaaag ctagttgttt ttcgtcacca   1651140
aatttcatat tttcagataa ccatctcaca caatcgggat ctgataaggt acagacgatt   1651200
aaacttaggt tatcgtaacg gctttcagtt tcataatcag gccagatgac ttttaagaaa   1651260
tcatacacct cttctgatgc aacaagttgt ttcgttttca taatttccga tactttcctc   1651320
tacctttaaa ttctattatt tctttgtctc ttaatatttg aagctgttgc ctaatctttt   1651380
ctttgatatg attgttctta acaaagatat tttttaggtc actttcaaaa cgatacatat   1651440
cttcaagggt aaattctgaa ccctctatct tatctataca atttagaatt tctattgtcc   1651500
aacctcttga tgacagagag ctcttcctta aaaataaacc ttgcttaaat tcttttgtaa   1651560
ctttttctgg atctctaact tgtccatctt gcacaagaaa tatccttcct ttagaaggta   1651620
cttgtgataa atcaatgtta caaccaatcc aacctgctcg tctagcagtt ggtgcaagtg   1651680
gttttctttg aataatcgat ttcggtgtaa caaattgctt cggaaggaca agaaagttat   1651740
ttacctcaaa attttttgtg taagttaaaa aaaagaaatt aggattatta tctgcctgca   1651800
cacgcttcat catcgttgca taagcaccat cattgattgt tgatgaaaaa tttccttttt   1651860
tgctctttag ttcaaactcc tcactacaat gattacagta aaaatctgct acaggccgat   1651920
tattttcaaa atgatttaag ggattgttcc cacaattagg gcaataagac tgacgataaa   1651980
cccaatcctc cgttaagata cgtgcctttt ggctattact tttataggtt tctactaatt   1652040
ctaaattaaa atgtaattcc atttaaaaat tcctcactaa tatgagaact cactcgatat   1652100
aagcaattaa aatctactat aactagtata ccacatatat gtacctatta catttgtatt   1652160
tcatcactct cttttatatt tccttctaac atatctcata aattaaaaat gagtgagata   1652220
aatttatccc actcaccttt ctttatatcc ttacccgtct ttcctcagac ctttggcctg   1652280
tgacaaacat ggtaaaggtt gctttgcaga catttctgcc ctcttgattg gtgatatcca   1652340
catccattac acaagttgta cgaccttgat ggacacattc tcctttaatg gtcaatacat   1652400
cgtcgagttt tcctgcctta aggtagttga tagaggattg gagtgtcacc ccatcaagtc   1652460
ccagcgagat aaccaccaaa ccactgattt ggtcacatag cgtgaataga tagccaccat   1652520
gggcattgcc atagtagttg agcgacgagt tcactacttt ggtcgtcacc acaacgtgac   1652580
catctctcat tttttcaatt tcgtaatttt caaaggcaga tatagcgtca aaatgaaagt   1652640
ctttcatcgt ttcctcctga tatttcaaac gacactatga tactactttt tataggactg   1652700
atgcaaggag aaagctccta gtctagtaaa attccgacct gttccacaaa gcgcataaag   1652760
gctgtctgcc cttgttctgt ctgcttgtag actcctgcat cctcaagtac acgcgcaaag   1652820
atagcaccca cagagtcctt gacgattgca agggcttttt ctttatccgt tagtctggat   1652880
gttgggattt gagttggtct gcccactcct gatgataatc ggcaactgta acagcttctc   1652940
ctacaagata gctagcgact tgctccactt cttctttcag acgtggtggc aagattgcca   1653000
agcccatgac ctcaatcaag ccgatatttt ccttcttgat atgttggaca tccttgtggg   1653060
gatgatagat accatcagga tactctgctg aagtctgatt gtctcgcaag accaagtcca   1653120
actcaaactg tccatcgcgt ttgcgggcaa tgggtgtgat agtgtgatgc ggtgtcctgt   1653180
ctgtctctgc caaaatctgc actgcaggat ctgaatactg gcgccattcc tgcaaaatct   1653240
tatcagccaa attgatcaaa tcctctttgg aatccgaagt caaacgtagg acagacatgg   1653300
gccacttgac aattccagcc ttgacctgct caaaaccagc aaatcggaag gccttttgca   1653360
agggagccaa ttccatagga aatacgtgac ggcctccctg ataatgatca tgagttagaa   1653420
tagagccccc cacaatcggc aggtcggcat tagatccagc aaaatatcct ggaaactggt   1653480
ctacgatagc caacagacgt tcaaaactct gacgactaat ggccatggga cgatgctggc   1653540
catctaaaaa gatacaatgc tcattaaagt aagcataggg cgaatactgg aaaccccatt   1653600
cctgaccaac catttcaaaa cggataatac ggtgattgct acgagctggg tggttaactc   1653660
gaccatggta gccctcattc tctagacaaa gctgacactg aggataatta ctagcttgca   1653720
ccaacttggc tgccacaatc tctttgggat ctttttcagg cttagagaga ttgatggtaa   1653780
tttcaagttc tccgtagtca gatggaacac gataagcgat atttctagca atggccttga   1653840
gtttgatgta gtcatttttc tgactgagtt ggtaaaaatc ctctatcgct tgttctggag   1653900
agtgggcgta ggttgcccaa aaatcacgat tgacctgact tggacaagga gtcaccaaat   1653960
ccatcagttc agcaccaagg atttcacgcg cagtctgact atcctcaatc gtctctaatc   1654020
gaacggcttc ttcaaccagc tggtccttga ggtcaatcaa tttatccaga ttggtctcaa   1654080
cttccaaaac accttctccc actcgtgcca aaacacgatt ggtcagatag attcgatcca   1654140
tttcctcaaa tgagctttca gaaatgacat gtgttacaaa tttatttact aaggtcacta   1654200
tagagcctcc ttttgactag tcaaggacgc gagtgccacc tgcaacttca gcgatataga   1654260
agcttggagc gtatccaact acttcctcgt agtgtttgcc tacagcttcc ttaaaggcct   1654320
caacagtatc tttttgaacc aaggcaatgg cacagccacc aaaaccagcc cctgtcatac   1654380
gagcaccgag aactccttct tgtgcccaag ctgtgtgaac aagggtatcc aattccaaac   1654440
cagttacttc ataatcatgc tccagagaaa cgtgtgacgc attcatcaag cgtccaaatg   1654500
tttccaaatc tcctgcttgg agtgctactt gagctttgag ggtacgttgg ttttcaagca   1654560
cagcatggcg agcacgtttc aaacgatttt catctttaat cagatagcta tattggtcaa   1654620
cggcccactc gtccaattca cccagagtct gaatatccaa ggaaacttgc aattcttcca   1654680
ctgctttttc acactcagca cgacgttcat tgtatttaga gtccgccaat tcacggcgtt   1654740
tgttggtgtt catgataaca acgacattgt ccttcaaatc aagtggcacc aagtcgtatt   1654800
ctaaagtatt agtatctagg taaatagcac gttggtctgc ccccatacca atagcaaact   1654860
ggtccataat gccagagttt actccgataa agttgttttc tgtttgtttg ccgattttaa   1654920
ccaaatcgag acgctctaat tttaaatcaa agagatgctc agccacgact cctgtcaaga   1654980
gttccaagga tgcagaagaa gacaagccag caccatttgg aatatttcca taaacataaa   1655040
aatcaaaacc tttgtcaatc acgtgcccag cttcttgcaa gaaatgaagg acaccttttg   1655100
gataattggt ccagttgtgc tctttttcaa acttgaggtc agcgagaggc acttcgataa   1655160
tgcccttgtc ctcaaagtta gctgagtaga aacgcaagac ttggtcgtca cgcttacgag   1655220
ctgcaccgta agttcccaag gaaatagcag caggaaaaac gtgcccaccg ttgtagtctg   1655280
tgtgttcacc aatcaaatta atgcggcctg gtgaaaagaa ggtttgatct gcttcttgac   1655340
caaaaacagc aagaaagtct ttgcgaaggg cttcagtagt aagatgttgt gccatatgaa   1655400
ttctcctttg actgtccgtt aagccatctt aacgtgtaat cgttttcttt ctattatatc   1655460
caaggaattt tccaaggtca atccttttta ctaaaatttt agtaaaatat cagtaaaaag   1655520
aagaaaaaca tgatatacta acctaatcaa ggaggattta tggctacctt aaaagacatt   1655580
gcacagctag cctctgtctc tatcgcgacc gtatcccgcg tcctcaaccg cgaccagagc   1655640
ctatctgtta cagaagaaac cagacaccgt attttaaccg ttgctgaaga gctgggctac   1655700
accaagcacc tcaagacagg cgagtcccac aaacccaagc aaaagattgc cattatccaa   1655760
tgggtcagcg aacaagggga gctggacgac ctctactact accagattcg cctaggaata   1655820
gaaaaaagag cccaagagtt ggactatgat atcttgcgct attttaatga ccaccctttt   1655880
accctaagcg aggaagtgat tgggattctc tgcatcggaa agtttagtcg agctcagatt   1655940
tctgcctttg aagaatacca aaagcctctt gtatttctag acagcgatac actttccctg   1656000
ggacatacct gtattatcac ggatttttac actgctatga aacaggttgt cgattatttc   1656060
ctcagtcaag gaatggaccg tatcgggatt ctaacaggcc ttgaagaaac aacagaccaa   1656120
gaagaaatca ttcaggacaa gcgtctagaa aacttcaaaa actatagtca agcgagggga   1656180
atctatcatg atgaactggt ctttcaagga agatttactg cccagtctgg ctatgactta   1656240
atgaaggagg ccattcagag cttgggagac caacttccgc cagcattttt cgcagccagc   1656300
gatagtttag ctatcggtgc cctccgtgcc ctccaagaag ctggaatcag cctgccagat   1656360
cgcgtcagcc tcatttcctt taacgacact agtctgacca aacaggtcta tcctcccctc   1656420
tctagtatta cagtttatac tgaagaaatg ggccgagcag gtatggatat tcttaacaag   1656480
gaagtcctcc acggtcggaa aatccctagc ctgaccatgc tgggaaccag actgacatta   1656540
agagaaagta ccctaaatca agaataggat aacataaaaa acgaatagag ttctaaaact   1656600
cctattcgtt ttttattcga ttacaatcat agacttaatt gtcttacgtt catccatatc   1656660
tttataggct tggtcgatat cttccagttt ataacttgaa gtaaagacgc gacctggatt   1656720
gatatcacca tcaaggacgg cttttagtaa aaattgctta tcgtatgttg tagcagaagc   1656780
tgccccacct gctacagaga tattttgcat aaatgtcgaa ccaagagcac gattattata   1656840
gtgtgggact cctacaaagc ccatacgccc tccattatga agaacaccta gcgcctgttc   1656900
tatagcagcc tccgtaccaa cacattcaag tgctgcatct gctcctccac cgaggatttc   1656960
acgcaccttg gtaattcctt cttgaccacg ttctgcaaca acagctgtcg cacctgactc   1657020
catagccatc ttttgacggt cttcatgacg gctcataagg ataatttgtg atgctccacg   1657080
catcttagcc gcgatgacag cacattgacc aacagcccca tcaccgataa caacaacctt   1657140
gtcccctttt tgaacatttg caacacgcgc cgcatgatag cctgtcggca tgacatctgc   1657200
aagagtcaaa agggacttga gcatcccttc tgtatagtca gaaggttgac cagggatttt   1657260
aaccagcgcc cagtttgcat agtggaagcg aatatattct gcctgaaaat caccccccaa   1657320
attattgcca atatgattgt cgcaagaacc gtcaaatcca gcaagacagg catcacactc   1657380
accacatcca tgtgtaaaag ggacaatcac aaaatcacct ggtttcaccg tcgtaatggc   1657440
ttccccagct tcttcaacaa tcccaatcgc ttcgtgtcca ctatttttgt gtccagcttt   1657500
cgtttctgga ttacggtacc tccataaatc tgaaccacaa acgcacgcac gaaccacacg   1657560
aataatcaca tcatccgctt ctattatttg cggacgttca atgctagcaa gtccaacctg   1657620
acctgccttt gtatatactg ctgatttcat ttaaaatttt ccttccttat aaagtttaat   1657680
tttgagattt aaacgattta aagctgtctg tagctgagac aagcgctcct ctaatttttg   1657740
cttttcctct tctaaaatac caagcctctc ctctctcgtt tcatctccct tttggtagag   1657800
cgacatatag tcaactaaac tatctacaga gacacccgcc gaacgaaaac acttaataaa   1657860
ttccagcgct tcgatatcct gatcttgaaa atcacgaatc ccagtagcag tacgagtaat   1657920
cggtggcaca agaccaaccc gttcataata ccgaatcgta tccgctgaaa ttcccaacaa   1657980
atcactggca gatttaatat tcacacgcta acctcctctc atttcattca ctgaattcac   1658040
gctattctaa ctcacttatc ttattatata actttgagtt gactccaagt caagcatttt   1658100
gtatctaatc gaaaaatttt tatcattaac aatcatatat ctggagttta tacaatgctc   1658160
ttctcttacc aatttttgaa atatttaaat aataaagaaa ttactctatt ccaaataaga   1658220
tagtacccaa gtatttttca cttttttcta atgttgatgc tcataactcc gttccaagtc   1658280
acacaccttt cgcttatggg tttggtgagt ttctaggtca gcatcaattt caatggtaat   1658340
attttgaaaa ccacaatctt ttaggaaaat tcgaatagac tctttacaag tttccatatg   1658400
ttccatttct tttagacaaa catggacaat ggcatttttt tccaaagcat ccatagtcca   1658460
gagattaagc tgattaaggc tggccacatt gtccaatcgc tccaggccac tctttacttg   1658520
cttgatatca agaccttctg gcacagcatc caagaaaatc ttgagtgtag accaaaaacg   1658580
tggaagggct tttgaaagaa taaagaaaga aatgacaagg gacaaaagag gatctaggat   1658640
ataccagtcc gtaaatcgaa gaacaatcgc catcaggata acagctaccc accctagcgt   1658700
atcttccaga aaatgcagac tcagaataga ctcattcttt gtctttccct taccaaccac   1658760
cagactcgct aacagattga tagtaatcgc aataattcct aaccagagaa tcccctcatc   1658820
attgactggt tgcggatgca aaatcttcgt gacattttcc aaaatgacta gaacagagcc   1658880
cgttacgaga atcacagctg ttaccaaggc tcctagcagg ctaaaccgct tatagcccaa   1658940
ggtgtactga ttgtcttctt cacgattgga gattgtttct agaaaagctg atattccaat   1659000
tgcaatcgca tctcccaagt catgcacaga gtcagcaaga acagcgctag aaccaaatac   1659060
tccacctgca ataaactcaa caatggcata agtcaaattt aagaaaaaag ccacccaaac   1659120
agcatatttt gccttcatat ttctcattcc tttgttataa tagatttatg aacaccttgt   1659180
tcattatcat tatccactaa aactcaaaga aaggatagaa gcaaaacgtc agctttattc   1659240
agttctgaac aatttgcctt aagtgtccat atgactaaca ttgaccgccg tatcagcaaa   1659300
accaaaaaag ccatctatca agcttttata caacttttga atgctaaggg ctacgaggcc   1659360
actactgttc aggatatcat tgatctcgca gatgtgggac gatccacctt ttactgtcac   1659420
tatgagagta aggagcttct tctggaccag ctctgccgct acctcttcca tcatcttttt   1659480
gaaagagagc aagccatttc aaccgaggac tacctcgccc acctctttct ccattttcat   1659540
aaaaaccaag accatatcac cagtctgcta ttttccaaaa atgactactt cctccgtcaa   1659600
ctccataaag agctagaaca ccatgtctat tccgtgctag ctgataattt aaaagaagcc   1659660
caccctaatc tgcctacttc ttacctccaa cacttggtca tgtccaactt tatcgagaca   1659720
ttgacctggt ggctcaaaaa aggtcaagat ttcacagacc aggaagttgt ccaattttat   1659780
ctagaccttc tcattcctaa aaattgaata tagagtaaag cttcagttgt cttatttcta   1659840
ggttactgag ttttttatct tttcaacaac aaaagaggac ccgccgatcc tctttttcat   1659900
actataaatc cttgattatc aactatatct gttttaatcg aaatctcaaa acagcacttt   1659960
caaacatctt ttcctagtta agtaaatcag tattctgctt agctgccttg ctccattgat   1660020
accaaccaac tagactgtta atgagataaa ttagatattt cccttgaatt tgcaggcttt   1660080
ctccccacca gagatagatt gaaaagacat tggtagccgc ccagaatatc cactgttcac   1660140
ggtaaacagc tgtcatgagg atttgcccta ccccattggt tgcatctgtg attgaatcac   1660200
gatagggacg attggcacca atagactgat aaatgaagcc aaaggccaac caccaaagca   1660260
cactaatgga aagatacttt gtccagccct tgccgtccag tttacgcgcg acaaactcct   1660320
gcttttcctt cttaaactgt gcctgataaa tccaaactag aagtccaatt ggctgcatga   1660380
ctgtgaagta aagtgtcgtc agcacctcac cataaaagcc tttctgtagg gccaaaataa   1660440
ggtaaataac agagttaatc aagccaaaaa gataattact tgctcgacct tccgatacaa   1660500
agattacaca gataatccct gtcaagctac aaatcatccc aatccagtca acaatacgat   1660560
gttcgtaaac caactccagc cagagaggaa aacttcctaa aaccagcaaa taaatccact   1660620
gggcaaaact acgatgggca aagaggtcat cccagatagc cttcatagtt cctgaaaatc   1660680
ctaaatcagc catagccgca accatacgac ggtaaccacc tgacatttca cctagggttg   1660740
ttttgatatt ttcaattttc ttttgcaaat aagtatgcat catttctcct tttgttttta   1660800
aagagccgtg tctggataga ctttcggacg caacgctcta ttagataatg aactgcctat   1660860
acacaagatt tctaacctta gtcgacatga gctgaaacct cttatttgtt aagtagttca   1660920
caaaatatta tacacctatt ttatgaatag tcaactgtct ttacagtaaa attttagaaa   1660980
atcatgaaaa ttttctcttt ctttccattt taagtgacat tcagtcattc tcacatcaaa   1661040
aaagcccaga cgaaattgtc tgagcattct tttatctagt cgtttaagga agttgagttc   1661100
agtatgttta aagtctctgt cccatcattt cttcaacaaa ccttgttctt ggagaaactc   1661160
cttggctact tgctttgctg acttgccttc aacaccgact tggtagttga gctggctcat   1661220
ctggctttct gtaatcttac cagccaatgt attaagaact ctttccaact ctgggtgttt   1661280
cttgagaaga gcttctttca tgagtggagc cccttgataa ggtgggaaga gttgcttgtc   1661340
atcttccaag acctgtaaat cataacgctc caattccgca tcagtcgaat aggcatccgt   1661400
gatttgaata tcccctgact gaatagcctg atagcgaagg gctggctcaa tggtcgctac   1661460
attgagattg agaccataca ttgattgcaa gcccttattt ccatcttcac ggtcgttaaa   1661520
ctcgagtgta aaacctgcct tcaactgccc ttccactttt ttcaagtctg aaatggtctt   1661580
caagccatat tcttgagcaa tctttttcgg aacagctaca gcataggtgt tttgataaga   1661640
catgggtttg agataggcta gatgatcctg cttagcaatg ccatcacgcg ccacctgata   1661700
aacctgttct ggttcatgac tcaccttggg tgatggttga agcaaacttt cagtcaccgt   1661760
accagtaaat tcaggataga tgtcaatatc gccttttttc agagcttcat aaaggaagct   1661820
tgtcttccca aaattcggtt taacagtcgc agtcatgctg gtattttctt caatcagcaa   1661880
cttatacata ttggccaaaa tttctggttc tggacctatt ttcccagcaa taaccaagtt   1661940
ttccttctct ttttgaacca aaagagctgg actataagac agacccagta ataaagccac   1662000
caaggcaaaa cctgagaaaa tcgtccgtaa ttttgctttt tccatcactt ttagtaggaa   1662060
gttaaaggca atggctagca ctgcagaaga aagtgcccca atcaaaatca aactggcatt   1662120
attacggtca attcccaaaa gaataaagga acctagtccc cctgcaccaa tcaaggccgc   1662180
caaggttgcc gtaccgataa tcaaaacagc tgccgtccga atcccagaca tgataacagg   1662240
catggcgagt ggaatttcaa atttcttgag acgttcccat ctggtcatcc caaaggcaat   1662300
cccagcctct tgcaggttcg gatcaattcc cttcagccca gtgatagtat tttgcaaaat   1662360
agggaaaatc gcataaatca ctagagctgt caaagccggc aaggtcccaa ttcccatcaa   1662420
agggataaag agccccaaca aggccagaga cgggatggtc tggaaaatac ctgcaatctg   1662480
caagacccag tcggccagct tctcatgata gcgaagaaaa acagccaagg gaatcgcaag   1662540
caaaatagct agtaacaagg tcaaaagcga caactgcaaa tgttgagata gagctgtcaa   1662600
ccaatcacta aaacgatcct gaaaagttgc aattaaatta gtcatgaaca ctacctccaa   1662660
acaagtctgc tacaaagtct gttgcaggcg cttttaaaat tgtctcggga ttcgctacct   1662720
ggcgaatttc tccatcctgc aagacagcaa tacggtccgc caacttcaag gcttcatccg   1662780
tatcatgggt tacaaaaatc gttgtcatcc caaactcttt atgcaattct tttgtcagaa   1662840
cctgcaactg ttttctcgaa atagcatcca aggccgaaaa gggttcatcc atgaggaaaa   1662900
tcttgggctg accaatcata gctcggacaa taccgacccg ttgctgttct ccaccagata   1662960
attcactagg taagcgatgc ccatactcgg ctactggtaa accaacctta gccaaaagct   1663020
cttctgtttt cttcgtaatt tcttccttgc tccacccctt catttcagga atgagagcaa   1663080
tattttccgc aactgttaga tttggaaaaa gagcaatagc ctgtaaaaca taaccagtag   1663140
aaagacgaag ttcacgctca tcatagtctt tgatgcgctt cccatccata taaatatttc   1663200
catcagttgg ttccaaaaga cggttaatca tcttgagcat ggtcgtctta cctgacccag   1663260
aaggccctac taaaaccata aattccccat cctcaatctg taagttgaca tctctcaaga   1663320
catccttttc tgtgtagcgc agtgctacat ttttgtattc aatcattctt tgtcctcaat   1663380
ttaaaacttc cctcgattgg tcaagtcttc taccttaggc ataacttcct tattatccca   1663440
atgctccaca attttcccgt tctctaaacg gaagatatcg tactgggcat aagcaacgcc   1663500
atcaatctga gtctgaccat agctaaccac atagtttcct tgtcctaaga gttggaaaac   1663560
aaagtcaaaa gtgacactat attcagccac atagttttta taagcagcac ttccttgtcc   1663620
aatatcatga ttatgctgaa tcaaatcgtc tgccacataa tcactccact gctctagctc   1663680
cccattttgg aaaatttctg tcaagaaacg gcgaaccagc tttttatttt ctgctttctt   1663740
atccaaatcc ttgatttcaa aatctccaaa aatttgatct agttggtcat tttcaggtgt   1663800
tcgatagtag tcaatgacat cccaatgctc aacaatacaa ccattctcat cctcacggaa   1663860
agtatccgtc gtcacccatt gagcttctcc accattcaga tattgatgaa catgaacaaa   1663920
gaccagattg ccatcctcaa tggtgcggac aatcttaatc tgacgctctg gatgacgctc   1663980
aaagaaatct gcaaagaagg ctgcaaatcc ttctttcccg tcaggaacac ctgtcgaatg   1664040
ttggatatag gtatccccta cagactgggc ttgagcctca gcaactcgtc cgtcttgaat   1664100
ggcatggatg tataggttgt gagcattttt cacttgttgt gacatattct aaacctcatt   1664160
tcccttctct ttcagattcg ccaaaattct ttcttgaaaa ccttcaaatt ggtgaatttc   1664220
ttcctctgaa aatcctttgt aaaagatagt atccaatttc tgactgacac gatgccccac   1664280
ttctttctgg gacttgccta actccgttaa aactaaatac ttcttacgct tgtcttttcc   1664340
acacggacta acaattacaa gcttttgttc ctctagcttt tttatcatag tcgtcagcgt   1664400
attattcgca agtccagtcg caagcgcgat atctgtcgca gttgcgcagc cagtttcact   1664460
attccataaa accgctaaaa tcttgccctg ttcaccccta taaagagcct caggatcttg   1664520
actcagtaac ttttgaaaaa tccgcccatt caacaaacga atatgatggg ctagcaaatg   1664580
accatctttc ataacacctc caatttattt cgatatcgaa atgaataaaa caattgtaac   1664640
actcatcgtt ctaactgtca actatttcga tttagaaata atttttgata attatccaca   1664700
ccaccatact ccggctcaac taacttttaa cgagagtttc taaactcctt cgtcctccag   1664760
tctacaaaag ccttccattc gtactatcct atattttatg aggggacaca tttttcctat   1664820
cagaccattt attttaaaga tagaagtaaa tcataattgc ttccatctgt tcttttatag   1664880
tatattgaag ttagactaga gcactgtatc ttctaaaaca ttgatagaaa gcgatttgaa   1664940
tttcccaatc aatttgttcg tatttatagc atttcgaaac tggaatagga caccatgact   1665000
gctaaaagat ttctataaat tcatttaatt tcctcaatca atttgttcat atcttatttc   1665060
attccgctat aatttcacct taccctatct ttttcgtagc acccttcaaa cagcctatcc   1665120
cctaccgttt gacgattcct cacttcgctc cacttccatt acagaagttt cttcactact   1665180
atgggctcgg ctgacttctc atgattcctt gttactacta tttgaacgct cacgagatag   1665240
atcttacaaa aaatgctttg atccacaatg gaatcaaagc attttaaaga gttcctcata   1665300
cataagcgca gaagtcgcag ttcctctgta cttggcttct tctcttttga caaagcgagc   1665360
caagttgagc aactcaggtg ctggatgttt gggatttagg agcaattcac gattgaccag   1665420
gcctgagaga cgaactgcct gcaattgctc atttgtagta ggcagttttt tagtagtctc   1665480
taggagagca gcaactaaat cttcactcaa atcatgtcga gcatgattgt aaagatcttt   1665540
tataaggctt tctaggtttg gttctaccat ccctaccacc tcccttatgg tttaataatg   1665600
tttaatcaaa tcaaccgttg aacgatccaa tttcttcacc aaggcttgta agaaagcttg   1665660
cgcttctagg aagtcatcca ttgcatagag ggtttggtga gaatggatat aacgagcgca   1665720
gacaccgata gttgttgatg ggacaccacc atttttcaga tgagctgcac ctgcatctgt   1665780
tccgccttta ccacagtagt attggtactt gataccagct tcttcagccg ttgtcaaaag   1665840
gaaatccttc atccctggga gaagcaagtg acctggatca tagaaacgaa tcaaggttcc   1665900
atctccaatc ttgccttgac caccgtagac atcacctgct ggtgagcaat caactgcgag   1665960
gaagacttct gggtcaaact tggttgtaga ggtatgagcg ccacgcagac caacttcttc   1666020
ttggacgtta gaacccagat agagttcatt gccgagtttt tgacccgata aagcttcagc   1666080
tagctcgctt accatgagga caccgtagcg gttatcccaa gcttttgaga tgatattttt   1666140
ttcattggct gtcaaaattg cagaactatc tggtacaatg gtatcaccag gacggatgcc   1666200
aaaactttct gcctcagcct tgtccgcaaa accaccatca aaaacgatat cggcaatggc   1666260
tggcatggtt ggtcccccct ttccacgagt caaatgcgga ggaacagaac ctgaaatcac   1666320
aggaatttca tgaccatcac gagtcaagag tttgaaacgt tggctgctaa ccaccatggg   1666380
gttccagcca ccgatttcta cgacacggaa ggtaccatct ggcttgattt cgctgaccat   1666440
aaaaccaact tcgtccatat gagaagcgac caagacgcgc ggtgcatcca cagcttctga   1666500
atgtttgata ccaaaaatac cacccaagcc atctgtcacc acttcatcca catgcggtgt   1666560
caacttttca cgaagataag cacggacagg cgcttcatga cctgagactg cagcaagttc   1666620
tgttacttct ttaatttttg aaaataatgt tgtcatttca gttccttctt tctttcatcc   1666680
attttaccac tttttatagg agaaggatag tgggaaggtg gatttctaag ttagtatctt   1666740
agtcctgctc tatcttagaa aaggatagta ttctcttgca tgtagtgcaa aatctagtaa   1666800
acattccaaa attaactcga atatttattt ccaaacaaaa aaacaataca ccatcaaagt   1666860
tgtttggatt tttcatgaaa tttacagaaa atagttgact tccctttctt ctttctttaa   1666920
atatatagtt ggttgagttt ggaatagtac gctgtagctg ctaaaacatt tctagaaatt   1666980
aatttgactt tcctaataga gttgttcata tcttatttca atttactata gtacaaaact   1667040
agaaaaggaa aaaatcatga ccaaaacaat tcttgttaca ggtgggacta gctacattgg   1667100
ctcccatacc gttaaagctc ttttaaatgc tggctatcag gtgcatgtcc tcgataatct   1667160
ctccacagga aatcgagcgg ctgtggatag tcgtgctagc tttaaagaac tggatgttta   1667220
tgatgctagc gccttaaagg cttacttaga agaaaatcag attgatgctg tcctccattg   1667280
tgcaggtgaa attgttgtga gcgaaagtat tgaaaatcca agtaaatact tcactgccaa   1667340
cgttgctggt atgaaccaag ttctcaaagt cttatctgaa gttggcattc aaaaaatcat   1667400
gttctcttcg actgcttctc tctatggaaa taactgtatt gacaagccgg tgactgaaga   1667460
taccctgctc gaccctgtca acccttatgc agagacaaaa ctgatgggcg aacgaatgat   1667520
ttactggatg gccaatcgct acgactggaa atatgttatt ttccgttact ttaatgttgc   1667580
tggggctgaa atggatgctt caaacggtct gcgtgtgaaa aatccaactc acatcattcc   1667640
aaatatcaac aagaccgcat tgggacaaaa tgatagctta aaaatatttg gagatgacta   1667700
cgatacacgt gacggttcat gtattcgaga ttacatttat gtcttggacc ttgcataggc   1667760
tcatgttaaa ggaatgaact acctatttca agaagacagt tcttctcaaa tctttaactt   1667820
aggaactaaa aaaggctata ctatcaaaga aatctttaaa actgctgaag aattactaaa   1667880
ttaaaaaatc ccacacgaga ttgttgctcg acgtgctagt gacccagcca gtgtcctagc   1667940
agatgcttca aaagctaaac aatatcttga ttggacggct agctactccc tcgaagatat   1668000
tattttatca gattaaggta aaaacatttt agaataggat aacaaaggag aaagtcttgt   1668060
tgctctctcc ttgttgtatt tattaaattg tcagaaattt tattgacaga ttagaaaaat   1668120
aatgttacat ttatatccgc agatatcttt cgataccaaa tctacatgaa aggacggggt   1668180
atgaaacttt ctcattattt aattggctta cttctactcc tagtctttct ctctattagc   1668240
attgggacca gtgatttttc atggggaaag ctatttgatt tcgaccagca gacctggctc   1668300
ctctttcaag agtcccgtct cccaagaact atcagtattc tcctgactgc ctctagtatg   1668360
agtatggcag gccttctcat gcagactatt acccaaaatc agtttgctgc accgagtaca   1668420
gttggaacga ctgaagccgc caaactggga atggtgctga gcctttttgt ctttccatcg   1668480
gctagtctga cccacaagat gctcttcgct tttgtttcat ccatcgtatt caccctcttc   1668540
ttcctagcct ttatgaccat ttttactgta aaggaaaggt ggatgttgcc tctgattggg   1668600
atcatctata gcgggattat cggctcagtc acagaagtta tcgcctatcg tttcaatctg   1668660
gttcagagta tgactgcctg gacccagggc tccttctcca tgattcagac ccatcagtat   1668720
gagtggctct tcttaggcct catcatcctg ataaccgttt ggaaattatc ccaaaccttc   1668780
accatcatga atctagggaa agaaaccagc gagagtttgg ggatttccta ctccctactt   1668840
gaaaaactgg ccctctttct ggtggcgcta acgacaagcg tcaccatgat taccgtgggt   1668900
ggcctaccat ttctcggagt tatcgttccc aatcttgttc gcaagcgcta tggagataat   1668960
ctaagtcaaa ccaaactcat ggtcgcactg gttggtgcca atctagttct ggcttgcgat   1669020
atcctatccc gagttctgat taggccctat gagttgtctg tcagtctctt gctaggaatc   1669080
atcggtagtc tcgtctttat cctacttctc tggagagggg gacgaaaaga tgcagactaa   1669140
aagcaaacat accaagctct tctggattct cattattctt gccatcggag cttgtcttct   1669200
ctacttttgg cccatcactc acttgtcagc ctttgcttgg aagttgcgtt cccaaaagat   1669260
catcgtttat ctcttggtag ccatcgcgac tgggatttcg accattagtt ttcaaaccct   1669320
gacggaaaat cgcttcctga cgcctagtat tttgggaatt gaatccttct acgtcctact   1669380
acaaacccta ctactggttt ttgaaagcaa gtttcttcaa cttggcaaat cccctatctt   1669440
agaattccta gtcttacttc ttgtccagtc cctcttcttt ctcgccttac aaggttactt   1669500
gaagacactg atgaagcaag acctggtctt cgtcctgctg atctgtctag cgctcagaag   1669560
tctctttcga aatatcagca ccttccttca agtcctaatg gatccaaacg aatacgataa   1669620
actgcaaaat agtctttttg cctcctttca acatctcaac acttccatcc tagccatcgg   1669680
ttctctgatc atcctcgctt tgacaatctt tttctttcga aaagcagtcg ttctagatgt   1669740
cttgcacctg caaagagaaa cggctcagat attgggactc gatgttgaaa aagaacagaa   1669800
agagctcctc tggggaatcg tgcttttgac ctcaacggcc actgccttgg taggacctat   1669860
ggccttcttc ggctttatac tggccaacct cacctacctg attgtcaaag actatcagca   1669920
caagttactc tttatagtgg ccattctggt tggatttatt agcttaacct tggggcaagc   1669980
cttgattgaa cgagtctttg cactggaaat tcgtatcagt atgatcattg agagtgtggg   1670040
tggcttctta ttctttatct tactatatag gaggtctcgt cagtgaaact ggaaaacatt   1670100
gacaaatcca ttcaaaaaca ggatattttg caaggcattt cgcttgaagt cagtcctcaa   1670160
aaactgacag cctttattgg tccaaatggt gctggaaaat cgactctcct ctccatcatg   1670220
agcaggctaa ccaagaaaga tcagggagtt ctcagtatca aaggacgtga aatcgagagc   1670280
tggaattcgc aagaactggc ccaagaacta accatcctaa aacagaaaat caattaccaa   1670340
gccaaattga ctgttgaaga actggtcagt tttggacgtt ttccctacag ccgaggtcga   1670400
cttagatcag aagactggga aaaaatccga gaaactctga actatttaga actgaccaac   1670460
ttaaaagacc gctacatcaa tagcctgtca ggggggcaac tccagcgcgt ctttatcgct   1670520
atggtactgg cccaggatac ggactttatc ttgctggacg aaccactcaa caatctcgat   1670580
atcaagcaaa gcgtcagcat gatgcagatt cttcgacgac tggtggagga actcggcaag   1670640
accattatca tcgtcctcca cgatatcaac atggccagtc agtatgcaga tgaaattgtc   1670700
gccttcaagg acggccaggt ctttagcaag ggaagaaccg atcaaatcat gcaggctgac   1670760
ctgctcagtc aactttatga gattcccatc acgctagctg atatcaatga caaaaagatc   1670820
tgtatctata gctagtaaca taaaagctca agttagagaa ccttcagtct cttagtcaat   1670880
aagattaaga gactccctaa atcgttatca cattttaaaa aggagaaatt atgaaaacat   1670940
cccttaaact ttatttcact gccctagtgg ccagcttctt gctcctactt ggtgcatgta   1671000
gtacaaactc aagcactagt cagacagaga ccagtagctc tgctccaaca gaggtaacca   1671060
ttaaaagttc actggacgag gtcaaacttt ccaaagttcc tgaaaagatt gtgacctttg   1671120
acctcggcgc tgcggatact attcgcgctt taggatttga aaaaaatatc gtcggaatgc   1671180
ctacaaaaac tgttccgact tatctaaaag acctagtggg aactgtcaaa aatgttggtt   1671240
ctatgaaaga acctgattta gaagctatcg ccgcccttga gcctgatttg attatcgctt   1671300
cgccacgtac acaaaaattc gtagacaaat tcaaagaaat cgccccaacc gttctcttcc   1671360
aagcaagcaa ggacgactac tggacttcta ccaaggctaa tatcgaatcc ttagcaagtg   1671420
ccttcggcga aactggtaca cagaaagcca aggaagaatt gaccaagcta gacaagagca   1671480
tccaagaagt cgctactaaa aatgaaagct ctgacaaaaa agcccttgcg atcctcctta   1671540
atgaaggaaa aatggcagcc tttggtgcca aatctcgttt ctctttcttg taccaaacct   1671600
tgaaattcaa accaactgat acaaaatttg aagactcacg ccacggacaa gaagtcagct   1671660
ttgaaagtgt caaagaaatc aaccctgaca tcctctttgt catcaaccgt acccttgcca   1671720
tcggtgggga caactctagc aacgacggtg tcctagaaaa tgcccttatc gctgaaacac   1671780
ctgctgctaa aaatggtaag attatccaac taacaccaga cctctggtat ctaagcggag   1671840
gcggacttga atcaacaaaa ctcatgattg aagacataca aaaagctttg aaataagcca   1671900
cttcaaactc aatttaatac tcaatgaaaa tcaaagagca aactaggaaa ctagccgcag   1671960
gttgctcaaa acactgtttt gaggttgcag atgaaagctg acgcggtttg aagagatttt   1672020
cgaagagtat aaaattttga cattctaaaa cgcatcctat caagttcact caaacctgat   1672080
aggatgcgtt tttatcattt tgaaatctat ttaccccacc tcattcccct tcttgatttc   1672140
gtttaaggga aaagcggtct ggaacggggt ccttacctgt tttcgaccag ggatgacaac   1672200
gtaaaatccg agccaagccc atcaataccc ccttaaaccc atgtttttca atagcctgaa   1672260
tcatgtagtt ggaacaagtc agctcaaagc gacaagaggg tggaaagact ggtgagataa   1672320
aacgttggta aaagcgcaca ggcgctatta aaattcgttt cattatttct tagttacagc   1672380
catggtgtgt agttggctga tttctttttt attaagacga cgggattctc ctggacggag   1672440
tcctgtcaag tctaggtgtc cgaaacgagt ccgagacaac ttatctactt ggagaccaac   1672500
agcttcaaac atctttttaa cctgatggtt acgcccttca tggatggtca actgcaccac   1672560
agagcgattt ttgactgggt ccactttgag aatttcataa acagctggct tggttttctt   1672620
accatcaatc tcaagaccac gggtcaaggg gcggagattg tccttattgg ccacaccttt   1672680
aacacgcgcg acataaacct tgtcaatctc attacgaggg tgaatcatct cgtctgtaaa   1672740
gtccccatca ttggtcaaaa tcaagacacc tgatgtatcc cagtccaaac gacccacagg   1672800
gtaaatacgc tctttgacat tgggcaagag gtcgacaacc gtcttgcgac ccttatcatc   1672860
tgtcacactg gaaatcacac cgcgtggttt gttaagcaga tagtagacct tttcttcgtt   1672920
gtagataggt tgaccttcaa cttcgacctt gtcgcctgac ttgatagtgg ttgctagttc   1672980
acgcaccact tggccgttaa ccgtcaccaa gccttgctta atcagctctt ctgcttttct   1673040
cctactggcc acacctgcgt gggcaatata cttattgatt ctcatcttct tctatccttt   1673100
caccaaataa ttggctttct tgggcttgaa tctcaagctc atcaatcact ggtaattctt   1673160
ctaaatggtt tatccccatg taatctagga aataatccgt agtcacatag aggttggggc   1673220
gccccaatac ttcctttttc ccgtcttcct ttatcaggtc aaaagcctgc aactttgcca   1673280
aggctccact cgagttaact ccacggatgg catcaatttc tatccgcgta atcggctgtt   1673340
tgtaggcaat aatggacaag gtctcaaggg cagcccgaga caagctctgg ttgataggcg   1673400
ccttagagta ttccttcaaa atctctgcaa attgaggctt ggtcaccaat ctataagcac   1673460
cacttgtctc aatcaaagcc aaactggaat ctgggtcctt ttcatacttc tgggctaatt   1673520
ttcctaaact ttgctggatg cctgtcggtg gcagagagag gagttcagct aactggcgga   1673580
cccgaatccc atcttcaccc gctacaaaca agagcgcttc tatttttgct aaagtactca   1673640
tctttcctct ctatcaagtc tagctttgag gcacttgact ttcttccttc ttttccatga   1673700
gatagatatc tccaaaactc tcctcttgca cgaggatcaa ctcctgggtt ttgattaact   1673760
ctagggttgc caaaaagagg gtgatgacct cttggacatt ctgggcttcc ttgaacaaat   1673820
cctgcaagcg caattgatct cgtccaatca aggactcttt cacgataatc atcatgtcct   1673880
caatcttata ctcatcccgc aagatcgtcg tgtgattttg tgcaaactcc tcttttttct   1673940
tggctaggat atttgaaaaa gtcaaaaaga ggtcaatggt cgtcttgtca tgcacaagct   1674000
ccgcatcttc gtaaatcaac tctgtcggcg ctttggaata atactgggcc cgttcttggt   1674060
gcttggcttc caagtgctca cccaagagct tgaacttgcg atattcttcg atttgagaga   1674120
ggaggtcctg ctccaggtca tcccccaagt ctgtcacttc tgctaccttc ggaaggagtt   1674180
tacgactctt aatcagcatg agctgactag ccatgaccat gtactcaccc gtcacttcca   1674240
gacgcatggc ctgcagggtt gagacatagg ctagatactg ttcgatgact tccgtaatgg   1674300
gcacatcgta gatatccatc tggtacttag aaaccagatg caagagcaag tccaggggtc   1674360
cttcaaaatc ttttaattta atatccatta tctatatttt tctaaggtca ggactgtttt   1674420
taatcctaat ttttttgcaa tttcgtacaa atcgaccttg ttttctattt gtcttagaat   1674480
aaactgttca cgtaagactt gagctgataa ggatggaaaa cctttctcct tgacaaaaga   1674540
ttctaactga cgaaaggccc actgacgaga atagggtttc tctcctcttt caaaaagata   1674600
ggtctgcccc atcaagggtt ccaattctga aagcaaggcc gtgggaatgg tgacaatcct   1674660
ctgttgggaa gccttgctga ttcgcaacac ctgaaaatcc agattgatgt ccgcaacctt   1674720
gatggctaaa atctcactgg gcaagagccc catttctagg attaagagcg ctagcaagcg   1674780
gccctctgga tggtcgcttt cctgccaaaa agagtctagg tatagaatct ctggcttttc   1674840
cgtcttcttt tcagcttgtt tggctaattc caagcggtaa aagctgtcca cctctccttt   1674900
ttgatagaga aagtatagaa attggttaca ggccgaaatc tttcgcttct gggcgctgat   1674960
ttttagattg gctagctggg cttggtaaat cttgagactg gtctcagaaa tccgctcacc   1675020
taccatgtct aaaaattgct ccaaatcata cttataggac tgcttggaat tgacagacaa   1675080
gccctgcttt tcctctaaaa aggctgaaat cctgtctctc attggcatcg aatctcatat   1675140
tccttactaa agtcatgcaa gagggcatta acggccttga ggatggactt gcgcgtaata   1675200
atcccttgga aaataccctc tgcatccaca accggtaaga aggactcatc tactagcttg   1675260
tgcaagacct ccgtaatggt gaaatcaggc gaaacaaccg ctacgtccgt ttttgtcata   1675320
tgaacgatat ccgtatccgc catgatttct tggctcaagt catgctccat ctgataagcc   1675380
ataatatctc tgagtccaat cgtcccaaca aactgttttt catctgtcac aacgggaaca   1675440
cgggtatagg tcatctgact gagcaagagg gtcgcatgat ccgcattgtg ggtatcaatc   1675500
aacacagcta gatttttagc aggggtcaaa aaagtttcct cctgccccaa caagaaagtc   1675560
tcaaactcct tggcaatcat cggctaaact ccttggacaa acctggatac acctcgtgat   1675620
ctcgtgtcaa aaagtccact ttgaagtaac tatcatcaat ctccacacga gcatagagac   1675680
attctctgat ggtacctcgt ggttgactga tagaacctgg atttagaaag aggatcttgc   1675740
cttccaacca agcacttggc acatgcaagt gaccatagag gcagatagcg gcctcttcct   1675800
cctgagccca gtagtccaac ttttgaaagt tgaaattgat gtcaaacaag tgaccatgag   1675860
tttggataat cttggtcgaa ccaagctcag tcaccagacg ttctgggtag ccggcgtaga   1675920
agtccatgtt ccctttaaca acgcggatgc cctcccaaag tggagaatcc ggacgtagtt   1675980
cagaatcgcc gttatgaaaa acagcatcga ctttgcccac atagcgatca cggacttctt   1676040
ccacaatcaa gctatcgcca tgggaatcgc tcattacaat gatggtttgc tttgccatga   1676100
tggaaatacc tccaaaagtt tcttaacggc taaggcacgg tgagattgac tatttttttc   1676160
ttccagggtt aattcagctg atgactcacc tgtttctcct acaaggaaga ggggatcata   1676220
gccaaagcca ttttcaccct taggttcaaa gttaatataa cctgaccagt ctgcttcaac   1676280
aactaaactt tccttatttg ggctggctac gactagggtt gtgtggaact gagccgagcg   1676340
gtccttgagt tcaaagacca tggccaattc gtgcaagagt ttggcattat tttcacggtc   1676400
agttgctccc acacctgcga aacgagctga ccagacgcct ggtaagccac caaggacatc   1676460
gactttgaga ccagaatcat ctgccaaaac catcttgccc gttaattgag aaatggtttc   1676520
tgccttaagg cgggcatttt cttcaaaggt catacctgtt tctgctactt caggcaggtc   1676580
agggtagtca ttaagatttt ccacatcgta gcctaactta tcaaagatag ctcggaattc   1676640
cttggtttta ccttcgttac gagtcgcaat caacaaggtt tctctgacct tgcttgtctc   1676700
aaagaaatca tgaacattga ccccttcttt aggcaattct acatacaaga gttgcccatt   1676760
ttcaaccaag agcagggccc catgacgttg aataacttcc aagtttcgtc ccatttcttg   1676820
attaagcatg tctaccacaa aggagaacaa acggtagata gaaccatagc gtaaaacagt   1676880
aactgaaagc gggaaaccat actcttcatc tccaaatatt ttggagaatt caaacagagg   1676940
aaaatctgtc ttatagtcgc tcaaactgtt aacgccacca aaaatactat aagacccaac   1677000
ataccagtcc tggtcatcct tatattcata aattttattt gtcataattc tacatgctcc   1677060
acatgaatct ctttttccag ccattcttca ccaatttgtg caaaactttg gctactggct   1677120
gttgtgtaaa aacggtgatg gagtggtcca gcatcgcgac cacgattgat ttcaaaataa   1677180
ttgagtaaga ctgagatatc ccgtacgcac tctgccccac tatcgatgag ctgaaccttt   1677240
ggccccatca cattttggat aatagggcga aggagtggat aatgagtaca gcccaaaatc   1677300
aggctatcca cctttccaac caagggacgc agggtttcat agaccacctt cttggtaaca   1677360
ctggttgaca gggcacctga ctcaaccaag ggagcaaact tgggacaggc caagctctcc   1677420
acctgtaagt cgggatccag atcatggatt ttctgacggt atatgtctga ttgtaccgtc   1677480
atgggcgttc caatcactcc gattttccca ccttgactgg acttgatggc tgccgaagct   1677540
cctggcaaaa ttacacccaa gacaggaata tctagttgag ccttgatttc ttcccagacg   1677600
accgcagtcg cagtgttaca agcaatgaca atcattttga catccttggt caagagaaag   1677660
ttgaccagct gccaagtata ttcacgaatt tgctcagcag gacgggggcc atagggcgcc   1677720
cgcgccgaat ctccaatata gacgatttct tcatggggaa gctggcgcat gagctcgcgc   1677780
acaacggtca agcccccgac acccgaatcc aaaaaaccaa ttggtcgatt atccatacag   1677840
tcttctttct agtctttttt tctgattgat cgttcattat gattccttgt actgaacgaa   1677900
ctgaccgaca gcttgataga atgtcaacta cctctctctt aatcataatc aaatatcaat   1677960
agaatgcaag gaaaaagtct catccctaaa ccataaccaa catagtgaga agtctggaac   1678020
tttcatccca gacttttcct tatttatttt ttctttttat tgttagcaag ggctgccttt   1678080
tgttggcgga tgatttggtg gtaaacttgt tgtaccttag cttcgcttgg tttttgacca   1678140
tttgcactca aaagagtacg aactgcttca gcattcaaac gtgggttgtc agcaaattct   1678200
ttttcgattt gcttacgaac caagtacatt cctcctagag ctcctcctag aaaagctagc   1678260
acaatcaata caattgctaa aagtaaatcc atcatttttc tcctgtttct ttttgagtcc   1678320
ctttcattat accacaaact agccaccctg accagtttgt tctacacttt cagggatgga   1678380
atagacagca aaaagaaccc tgcttttctg aaaaagaggt ctccttgcta agtttatact   1678440
caatgaaaat caaagaacaa actaggaagc tagccacagg ttgctcaaag caccgctttg   1678500
aggttgcaga taaaactgac acggtttgaa gagattttcg aagagtatta atttacataa   1678560
atagccagtg tttgataggg tttgagtaga attttctcag acacttctgc atcttcatag   1678620
tttgatatca aaatctgtcc attttggtag actgctggca agtcgatttc cacttcttta   1678680
gcataaaagt tattgagcac tagtaacttt tgatcctcaa actggcgttc aaaagcgtag   1678740
acttgtttgc tatcttcaaa ggctggtttg taacttcctt ctgaaatgat tggcatttcc   1678800
ttacgcagtc gaatcaagtc ttgatagaag gtaaaaatcg gaccctggat ttcattttct   1678860
acattgatgt atttatagga tttaccagct ttcaaccaag gagtgcctgt tgaaaatcct   1678920
gcattttccg aagcatccca ctgcatggga atgcgtgaat tatcacgcga cttagcttga   1678980
ataatctgga aggcttcttg ctgactcttt ccttcttcta agagcatctg ataggcatta   1679040
agcgattcga catccacata atcagccata gaatcatagt ctgggtcaat catcccgatt   1679100
tcctcaccca tgtagatata aggtgtccca cgtgacaggt gaatgctggc tgctagcatg   1679160
gtggctcctt ccttgcggaa gttttgaata tcgacaaaac ggttcaaggc acgtggttga   1679220
tcgtgattat tccaaaagag ggcactccaa ccgtctttat cactcatttc cttaccccaa   1679280
ctatggtaaa gactcttcaa ctcttcaaaa tcaaagggag ccaaggtcca cttttgtcca   1679340
tccttatagt ccaccttgag gtgatgaaaa ttaaaggtca tggataattc ctgacgatca   1679400
ggcgacgaat agaggacaca gttttccatg gtggtagaag acatttcccc aactgtcata   1679460
aagctatcgt cggatccaaa agtggcttgg ttcatcatac gcaaatagtt atgaacgatg   1679520
ggtttgtctg tataagctgg cttcccttca ttttcaggac agtccactga aacctcgtcc   1679580
ttaccgatca aattgatcac atcaaatcgg aaacctttga cacccttgtc gcgccagaaa   1679640
ttaacaacct tgaaaagctc cttacggaca ttggaattgc gccagttaag gtcagcctgg   1679700
gtctcatcaa ataggtgaag atagtatttc ccagtatccc cgaaaggcgt ccatgcagaa   1679760
ccaccaaact tagactgcca atctgttggt tggtcttgga tgaagaaaaa gtcttgataa   1679820
tacttatcac cagctagggc tttctgaaac cattcatgct ctgtcgaaca atgattaagt   1679880
accatgtcca gcataaagtc aatcttgtgc tctttaccga cacacaccat tttctcaaaa   1679940
tcagccatat caccaaaaag aggatccact gccatataat ctgaaatatc gtaaccatta   1680000
tcccgttgag ggcttggata gaatggattg agccagacca tatccacacc tagtttggct   1680060
aaatagggaa ttttttcgat aatcccacgg aaatccccaa taccgttttc agtggtgtct   1680120
ttgtaagatt ttggatagat ttgatagact acttttcctt tatcaagtgt catctgtttc   1680180
tccttttctg ataaaaggga ggaagcagtc ttccgtccct atttgtgcta tttcaattat   1680240
actcaatgaa aatcaaagaa caaactagga agctagccac aggttgctca aaacactatt   1680300
ttgaggttgc agatagagct gacgtggttt gaagagattt tcgaagagta ttagattcgt   1680360
gtagcgacca tgagagatgc tccagcttgg atcgttgtcg gataagttcc gggaatagtc   1680420
gctgtataag catcttggtt ggtgatgata acaggagttt ctgtcaccag acctgcagcc   1680480
ttaatgacat ccatatcaaa acgaatcagt tgctgaccaa ctgtaacgtg atctccttgg   1680540
actacaagac tttcaaaacc tttgccatca agacctactg tatccatacc gatgtggatg   1680600
agcaattcaa ctccctcgtc agagacaatg ccgatggcat gcttggtagg gaaaagaacc   1680660
gtcactgtcc cattaactgg agaggtcaac tcaccttggc ttggttcaat gactagacct   1680720
tgccccatga cacctgatgc aaaaatagga tccgtcgctt gactcaattc tttcacttgg   1680780
ccagttagtg ggctgataat ttctaccgaa gtaagttcta ctggttcatg gttcacaaat   1680840
tctgcttctt cttgagcaac gaattctgcc tgcaagttcg tatcgccctc tgtttttgta   1680900
aagagaccag ccttgcggaa gaagaaagtc aagagcattg gaacaacaat cgcaactagc   1680960
atagttcctg caaatggcag catgtattga ggttgaatag agagaatacc tggcaaacca   1681020
ccgataccaa tagaagccgc agttacatta aaagtaacgg ataacatgcc tgcaagggct   1681080
gaaccagtca tcccagcaac aaatggataa atatatttta cgttaacccc aaaaagagct   1681140
ggttctgtaa caccgagata ggctgaaatg gttgcaggaa gtgaaacctg agcctcacgc   1681200
tcatcatggc gatgcatgaa ataataggca aacacggctg agccttgagc aatattagaa   1681260
agagcaatca ttggccatag ggcagtgcca ccagcatccg caatcaattg tgtatcaatg   1681320
gcattggtca tatggtgcag acctgtgatg acaaatggag cgtagagggc gccaaaaatt   1681380
gcaccgaaga gccatttaac tggaccagtt aaacctgcca agacaactga tgaaagtcct   1681440
tgtccaattg tccaaccgat tggtcccaaa acagtatgag ccaaaatcaa ggctggaatc   1681500
aatgacaaga aaggtacaaa aatcatagaa atgacttctg ggatatgctt gtgccagaag   1681560
atttcaagat aagacagact caaacctgca agcaaggctg ggataacttg ggcttggtaa   1681620
ccgatacgat taacagtaaa atagccaaaa ttccaaaccc agtttgccgc gatatcagct   1681680
gctggcgttg aagcaaccgc ataggcattg agcaactgag gcgataccaa acagattccg   1681740
agaacaattc ccaaaatttg gctggttccc atcttacgag aaacagacca agtaatccct   1681800
actggtaaga actggaagat agcttcacca ggcaaccaga ggaagtgatt gacacctgcc   1681860
caaaactgag aggattctgt gatggtcttg ccatccaaca tcgaccaatg gacaccttcc   1681920
aagacattac ggaaaccgag gatcaatcct ccgactatca aggctggaat aatcggagta   1681980
aaaatctccg ccagagtggt cataacacct tggaccacgt tttgattact cttagctgca   1682040
gacttggctg cttctttgga aacaccctca atacctgaaa cggctgtaaa atcattataa   1682100
aagatgggca cgtcatttcc aatgattacc tgaaattgac ctgcatttgt aaaggttcct   1682160
ttaacagctg gaattgactc gatagcttta acattagcct tcttatcatc tcctaaaaca   1682220
aaccgcatcc gtgtcgcaca gtgagttacg gcagtcacat tttctttgcc tccgattgcc   1682280
tgaagcagat ctttggcttc ttgttcaaat tttcccattt gattctcctt atacttgtca   1682340
aagcaagttt gatttgataa gtatattgta aacgatacca aacttgtctg caacttgttt   1682400
ggtataaaaa gggtgttttt ttgtaaattt tctagcactt gtatggtaaa atagatacag   1682460
gtgttcatta aactagacta aaaacctatt taagcaggca aaatgaagaa ataccaacaa   1682520
ttatttaagc aaatccaaga aaccattcaa aacgagactt acgctgtcgg agatttcctt   1682580
cctagcgagc acgaccttat ggagcaatat caagtgagtc gtgataccgt ccgaaaggcc   1682640
ctgtctctcc tccaagagga aggattgatc aaaaagataa gagggcaagg ttctcaagtc   1682700
gtcaaagaag aaaccgtcaa tttccctgta tccaacctaa ccagctacca agaactagtt   1682760
aaagaacttg gactgcgctc taaaaccaac gtggtcagtc tggacaagat tattattgat   1682820
aaaaaatcct cactgataac cggtttccca gagtttcgga tggtttggaa ggtggtccgc   1682880
cagcgtgtgg tggatgatct ggtatccgtt ctggatacgg actatctgga tatggaactc   1682940
atcccaaatc tcactcgcca aattgctgag cagtctatct attcttatat agaaaatggc   1683000
ctcaaactcc ttattgatta tgctcagaag gaaatcacca ttgaccactc aagcgaccga   1683060
gacaagattc tcatggacat tggcaaagac ccttatgtcg tttcgattaa atcaaaagtc   1683120
tatctccaag acggacgcca atttcagttt accgaaagtc gccataagtt agagaaattt   1683180
agatttgtag attttgcaaa acgcaagaaa taaaagactg agacaccaga tctcagcctt   1683240
tttcggctct ataatatttg tagtgggtaa cccccctatg gatattatgg agcctatttt   1683300
gtgtagaaaa aaagtcccat atgacctata atgaaaagcg acaaaacaac tcattagaaa   1683360
gattcatatg gaacaattac attttatcac aaaactgctc gatattaaag acccaaacat   1683420
caagattcta gacatcatca atatggatac ccacaaagaa attatcgcta agctggatta   1683480
tgaggctcca tcttgccctg attgtggaag tctaatgaag aaatatgact ttcaaaaacc   1683540
gtctaagatc ccttacctcg aaacaactgg tatgcctact agaattctcc ttagaaagcg   1683600
tcgtttcaag tgctatcatt gttctaaaat gatggtcgct gaaacttcta tcgtcaagaa   1683660
gaatcatcaa attcctcgta ttatcaacca aaaaattgcg caaaagttga ttgagaagat   1683720
ttctatgacc gatattgctc atcagctggc catttcaact tcaactgtca ttcgaaagct   1683780
caatgattct cactttgagc atgatttttc gcgtcttcct gagattatgt cctgggacgt   1683840
tgaaacagtc cggggagtga ctgtttcaat cgggagatgg agatgagctt tattgcgcaa   1683900
gattttaaca atttcaatat catcactgtt cttgaaggta gaacacaagc tgtcatccga   1683960
gatcactttc ttaaatatga tagagccgtc cgatgtcgcg tcaaaatcat tactatggct   1684020
atgtttagcc cttactatga cttggctaaa cagcttcgct ttcaaatttc taggctcagg   1684080
ctgaaacagt ctcccaggct gtttcactcc cgaatgctaa aatcgttctt gatcgctttc   1684140
acattgtaca acatcttagc cgtgctatga gtcgtgtgca tgtccaaatc atgaatcagt   1684200
ttcatcgaaa atcccatgaa tacaaggcta tcaagcgcta ctggaaactc attcaacagg   1684260
atagccgtaa actgagtgat aagcgatttt atcgccctac ttttcgcatg cacttaacaa   1684320
ataaagaaat tcttgacaag attttaagct attcagaaga cttgaaacac cactatcaga   1684380
tctatcaact cttacttttt cactttcaga acaaagaccc tgagaaattt ttcggactca   1684440
ttgaggacaa tctgaagcag gttcatcctc tttttcagac tgtctttaaa acctttctca   1684500
aagataaaga aaagattatc aacgcccttc aactacacta ttctaatgcc aaactggaag   1684560
cgaccaataa tctcatcaaa cttatcaagc gcaatgcctt tggttttcga aactttgaaa   1684620
acttcaaaaa acggattttt atcgctttga acatcaaaaa agaaaggacg aaatttgtcc   1684680
tttctcgagc ttagctgact tcaacccact acagttgaca aagagcctaa tttccataaa   1684740
aattgacatg gaaattataa aaccattact agtttagtcc tttttgataa cgtgccaatt   1684800
cggcttggtt cgcccaaaca tagtgacctg gacggatttc taccatagat ggcttatcag   1684860
tctcatagtc gtgttgactt ggatcgtaaa ccttcaagac cttcttacgt tccaagattg   1684920
gatctgggat tggtaccgct gaaagcaagg cttgagtata tgggtgaatt ggattgttaa   1684980
acaattcttc tgtttctgca acctctacaa taacaccctt gtaaataact gcgatacgat   1685040
ctgaaataaa gcgaacaacc gacaagtcat gggcgatgaa gagataggtc aggccgagct   1685100
ctttttggaa ttttttgagc aagttcaaga cttgggcacg tacagaaacg tccaaggctg   1685160
aaattggctc atctgcaata acaaagtctg gttgcatgac caaggcacgg gcaataccga   1685220
tacgttgacg ttgaccgcct gagaattcat gagggtaacg agtcaagtgc tcagcaagaa   1685280
gacctacttc acggataata ttttgaactt tctctttacg ttcttcttca tccttaaata   1685340
aacggtgatt gtaaagacct tcagaaataa tataatcaac agtcgcacgt tcattcaaac   1685400
ttgcggcagg gtcttggaaa atcatctgga ttcgacgaat caattccgca gcttgttcac   1685460
gcgatttctt accattaatc ttttgaccat caaaaatgat atctccatta cttgtatcat   1685520
ttagaccgat gatagcacga ccaatagttg ttttcccact accggactca cctacaagcg   1685580
agaaagtttc tcccttgttg ataaagaagt tagcattttt aaccgcgaca aacttcttac   1685640
ttccttcacc gaaggaaatt tctaaatctt tgatttctac taatttttca gacatttcct   1685700
tcctcctagt cagccagatg ggcaaatccc attttttcac ggatcttatc atggagattt   1685760
gcaatcacag ctggtttttc tactttcgga gcatcctcat gaagaagcca agttttagcc   1685820
caatgtgtct ctgatactga gaattgagga gctttttgtt cgaagtcaat ctgcattgcg   1685880
tagtcagaac gcaaggcaaa agcatcccct ttcaggtcag tataaagtga cggaggtgtt   1685940
cctgggattg agtaaagatc ccctttatca tcagcaagct gaggcaagct agacaagaga   1686000
ctccatgtat atggatggcg agggtcatag aagacttcct caaccgttcc atactcaacg   1686060
atttctcctg catacataac cgctacctta tccgcaatac ttgccaccac accaaggtcg   1686120
tgggtaataa agattgttgt gaaatgatac tcgttttgta aagattttag caaatcaata   1686180
atctgagctt gaatagttac atccaaggca gttgttggct catcacagat caagacatca   1686240
ggtcggcagg caagggcaat agcaataacg atacgttgac gcattcctcc agaatattgg   1686300
aatgggtatt cattaaaacg tctatctgcg tctggaatgc caaccttatt catgtagtca   1686360
atggccaatt ctttcgcttc tttagctgtt tttccttggt gttttacaat aacttctgta   1686420
atctgactac caattgtttt aatggggtcc aaactagtca ttgggtcctg gaagatagtc   1686480
gcaatcttag caccacgaat ttgttcccaa tccttgtgag aagataaagc tgtcaagtcc   1686540
tgaccacggt agtcaatact accttgggca atacgaccat tttcttcgag catacctgtg   1686600
aaggtctttg tcaaaacaga tttacctgat cctgactcac ctaccaaggc taatacttct   1686660
ccttcgacta gttcaaggga aacgccgcga atggctgtca atactttgtc acgaacgtca   1686720
aattccacga caatatcgcg agcagtcaaa attacatttt tttcttttgt catttctact   1686780
cctatctatg tgtacgtgga tcactagcat ccgctaagtt ttgaccaact acgaaaaggg   1686840
acaaggatac caagacaagg gttgtcaatg gaatccagaa caagtaagca ttggttgtta   1686900
cgttttgtga ataatccgaa atcaaacgac ccaaacttgg cactgtaatc ggtaatccaa   1686960
gaccgaagaa agacaagaag gcttcgtatg agataaagct tggaagcatt tgagtcatgg   1687020
ttgtcacaat aacagatacc aattgaggca tgatattttt ggcaacaatc ttcaaggttg   1687080
gtgttcccaa agtacgtgac gccaagttgt attccaagtc acgatagcgc aagatttgca   1687140
cacggatcat gaaggcaata ccaatccatg ttgttacgct catggcaaaa atcagattcc   1687200
agaatccagc tccgattgag taagtcaaga caataacaat caaaagaggt gggatgtttg   1687260
agatgacgtt gtaaacttcc atcatgacac ggtcaactga ttttgaaata ccccaaatac   1687320
caccgacaaa aacaccgata accaagttaa tcactgtcgc aatcacagaa atgaggatgg   1687380
agttacgagc tccgaaccag acaccgtcaa agagcgattt accgttactg tcagtaccga   1687440
accaatgctc cgcatttggc ttgatataac gaacactaaa gtcgtttacc ttgctgacat   1687500
cattgaaatc aaacttagaa aacattgggt agatgaaact tatcaaaatg atggctacca   1687560
agattcccaa catgactaca gttgattttt tcttcataaa ttgtttaaac actgatttcc   1687620
agtaagaata tgctggcgca tcaatagttt cagaggcaaa atcgtcacgt tttacaaact   1687680
gaaatttttc tttatcgatt gtagacatta tttgcctcct ttctcagtca atttaatacg   1687740
tgggtcaata atagtcatcc aaatatctcc caaaagacgt gagaagatag aaatacatgt   1687800
aaagatgaag acaagaccaa cgaccataga gttattagat gcttttacag agtcaatcaa   1687860
cattttaccc atacctggga aggcgaagac tgtttcagta agggttgcac caccgataac   1687920
cccaataatg gcagcaggaa ttcctgaaac cagcggaacc atggcatttt taaagatgtg   1687980
tttgtttgaa atttcttttt cagacaaacc ttttgcacga gcgaaacgaa caaagtcttg   1688040
agattgcaag tcaatcatgt aacgacgaat ccaaatggct gtaccaggag cacccaacaa   1688100
accaaggatg actgctggta aaacgtaaga acgccaatct ccagctccca agatagggaa   1688160
tgaatctgga agggcaatag atgatccaat caatcgaacg atgtaaacca aggcaatcgt   1688220
tggaagagca agcaagaagg tcaaagcccc tgttgagagg ctatcaatcc aagtgttctt   1688280
gaaacgagcc atggctgaac caagtggcac ggcaagagca taggcaagaa ccaaaccaat   1688340
caaaccagta atagcagagc tgacaatcat agatggatat tggtaattac tttcagtcgc   1688400
tgtataagga tcatctttcc catagctagc tacttcacga gagtcagcct gactaggtga   1688460
cttgtaggtt cttgagtaaa tatttacaga agacgttttc ttacctgttg ggaactgaac   1688520
ttgggcagtt ttggtttgtc cttgaccttg agtaataacc tgaagaactg gtgtattagc   1688580
ataggttggg taagagtcac ctaaattcaa gttcacaaag ttttgatgaa caaatgggaa   1688640
ctgactgtta aagtacaaga gatatttatg tttagttcct gaaccgacca atgaccatcc   1688700
gatagctgga tcattttcaa aacgaaggta gcgtttcaag tctggatttt cagggtcttg   1688760
gattttattt gtatggtcaa tgtcaatcaa gttagcatag aagtgaaaaa cacgttcaaa   1688820
aattggaatt tcacgagtag catagaattg accactttca gtaaattctc ccaaagtcca   1688880
accatgacct aattgattga tgtacttttc ataaatagct ttattggtcg catttgcttc   1688940
tactgttaca gaagaatcca tgctacttgc cttttcttgc aactctttag tatcgtaata   1689000
ctcaatgtag cccatacgct caaacacagt attttcatag ttatcacgtt tatcagccgt   1689060
tgtcgcaatt ttattatagt taggatcctg cttgaaaatc aattttcgag gaaccaaggt   1689120
atagataatc gtgtaggtca aagtcgttac taagaaaatc gaaaccaatg accgcaaaac   1689180
acgcataaaa atatattttt tcatattatt tcctttaaaa atcccaaaag aaccttctcc   1689240
tcatggagag aaagttctat tagaaattat ttacttcaca tgacttgcca attctttttg   1689300
agctttctca tttgattcag ctttttcttt caaccatttt tcacgagctt tttcatactc   1689360
ttccttagtc accactttat cttgtgattt caaatatttg aagtaaacat ctgacccctt   1689420
agagcctgtt tgcgcagaag ctccagtaaa tggaacaatt cgtgaaagca ctggtgctgc   1689480
accagaagaa gccatagcag gaataaagag tgaactatct gtcaaccatg cttgagccgc   1689540
tgcatatttt tcataacgga cattcaagtc gcttgtctct ctggcagctt catcaactaa   1689600
tttatcgtat tctttcaaac caacttgaac tactgaaggg ctatttggat tatcaaatcc   1689660
taaatatgtt tttgtagttt cactgctagt tgtttttaaa atatccaggt aagtagatgg   1689720
gtcttgatag tctggccccc atgaaactcc tcctgataca tcccaatcct cagatgaagc   1689780
attggcagca tagtaagtaa tattaaggaa ttcatcactt gtcatttgtt gaatatcaac   1689840
aacgacattt tcaacaccaa gaactgtttc tacagattgt ttaaaggact gaatacgaga   1689900
tatgtagttt tttgatgctt ggtctactgg aacgtccaga tgaataggaa actgaacgcc   1689960
gtctgcttct aaagctttct tagctttcgc aaactctgcc ttggccttgt cagcattgaa   1690020
taaaccatcc tgcccatcag ctaaattcac acctttccac tcatcaccat aagcaggaag   1690080
ttgagcagcg actaaatcac caaaggtctt ctcaccagct gaaacaaagt ctggttttac   1690140
aaataaatta cgaactgcta aagctgctcc atctttacca ttgatttgag ctgagtaagc   1690200
tgagcgatca agagcaaaat tcaaggcttg acggaaatct ttgttaagca atgccttctt   1690260
agtagctact ttctctgaat ctgtagtttt agaagtatag ttgtaacttt ggcgatcaat   1690320
attcacaccc agaccagcaa tcccagagcc tgattgtgtg taatagatat tgtccttgta   1690380
ttcttctgca accttagaat agttggagct ggtagggtaa agacgggcat aactataagc   1690440
tccactagtg aagttacgct ctagcgactc ctgatctgat ccatcatagt aagctagatt   1690500
gatagtatct aggtggacat tttctttatc ccaatattgc tcatttttta caaactctac   1690560
agaagatttt gcagtcaacc ctttcaacaa gaatggacca ttataaagca aggatgtcgg   1690620
atctgttggt ttagcaaaat cgcttccttt tgatgtttcg aattcttcat tcagaggcca   1690680
gaaaatagaa taggtcaact tagagttcca gaacggttca ggctggttca aagtgtattg   1690740
taacgtataa tcatcaaccg ccttgacacc aactgttgaa aaatctgttg aagttcctga   1690800
tagataatct gccaagcctt taaccgaatt ttcagctaaa tacatagctt ctgatttttt   1690860
atctgctgcg tgttttaaac cgttcacgaa atctttagcc gtcacctctg catattcttc   1690920
tccatcagag gtaaaccatt taaccccttt acgaatctta taagtgtagg tcaaaccatc   1690980
cttagagact tcccaatcct ctgcaactgc aggagcaaga ttaccgtaat tatcgttagt   1691040
gaataaacca tcaatcccat ttgaagtcac tactgttgta ctatttttac ttgaaatcag   1691100
gtagtccaag gtttctgggt ctgctgtata aacatagcca taagctttag gggctgatga   1691160
atcagatgat tttgaagaac tgcatgctgc aagtacacct gctgctaata aaacaagacc   1691220
tgctgtagca aatacacgat tttttttcat tttctactcc tctgtttatg tgaattatag   1691280
attgacaacc attatatcac attatccatt aaaaatcaaa caaattttca gaatatttag   1691340
gcttgttggc acaaattttt catttttttt gaatatatga ttcaaattgt cgttcgaagt   1691400
gtcaaagact acagtgaaaa taggaaattt gacgcagaaa ctttggagtt taggaagaca   1691460
tacagtaaaa tgaaatacgg acggaacaat gtgattttgg aattcaaatt aaattataac   1691520
aatattgtag aagtatcatt ctagtattca agattcagtt tactatgtct tttcacacca   1691580
accttatccc gaattcaatt acttttgtga tttacatata tagattaaga ctatctttta   1691640
tactttaaaa tttctcgcta ccttatccac tatatgctcc tcgctatcac gtttctattc   1691700
atagcctacg atttcactat tgctttctct gacaattctt atttcctgcg tcagacttaa   1691760
aacgatctat ccccagacca ttttaatccg ctacctcacg atagtcaggc ttggggagcg   1691820
ctattgtatt caccggtagt ggagccctac agaggactta cacctcagat gcacgacatg   1691880
cccatcgtat aaaaaatctc ctacccaagg tagaagattt caaacttata aaacttaatc   1691940
cgtcatgtcc gataccaaca ttcgatgctc caatggaata ctgcacataa ctagcaagaa   1692000
aataaagcct gactgaatcc agaagagagc caagtcaaaa attccgtgca cagcaaccac   1692060
tgtaaggaaa gatagataaa ggccgataat cggacgtttc cccgactcct gactcatatc   1692120
catcatcaag cgaacaggag caacagaaga caaaactaat aaaatagtcc ccacaattcc   1692180
gtaactcaga atcgtatcaa tataaagact gtgggcatgt tcatgataag gagcatgtat   1692240
ccgaggataa gagttcatat aggtcaatgg cccttcaccc caaaaaggat tttgcttaaa   1692300
caaggccatc ccagcatccc agatagaaat gcgttcttcc atagaagagt ctaaagtacc   1692360
cattcgaact cccaaatcac tagaaaagag gaaactcaaa ccaatcgcga agaccccaat   1692420
actaagccaa aaggccttcc agtttttaat agtcgtaaag agatagataa ttgctccagc   1692480
gataatagca ggaaaggcag ttcgattttg agtaaagttc aaaccaaaga gattaacaaa   1692540
gcctgcaatc acacagaata ctttcaacca attcaacttg gtcgttgtaa acagatagaa   1692600
agcaatcata atacagaaac aacaaataat tccataataa ttaggattaa agaaggtcac   1692660
ttctgcccgg ttctgatgcc acacctgcat attgggtgaa agaaaagcat agttaaattt   1692720
cttcacaatt tggaaatgtt ctaaactggc aaaagcagct gacaagacac taccaaacaa   1692780
gacaaactgc aaaatcaatc gaaagaattt atgggataaa atcgactgat agtgcaaaaa   1692840
gaaaatagta aatagaaaca ttcctactga agccacaaga cccatccaat tttgtgcaag   1692900
aatggatata acagtactat agctaagaaa aagaagcagc atcggatgct cccccatttt   1692960
ctgaagaata cttttcatgt ctcctgtaaa aatcaaactg ataatatata aacagagtac   1693020
aactacaaaa agataaaagg gtaaaaagat actcaggata attcccaata aaatcagctc   1693080
tttactagac aaccccttca gcttttcaat aaagcctatt gatttcaaaa tgaatccttt   1693140
ctctccaaat cagctgattc agataatagt aagctatcct atattgtacc acttttttag   1693200
caatttgaaa acaaaggaaa cgttttccaa aataaaaacc ctattttatc caccatatca   1693260
aggcttcaaa atgatacttc aactccattc tcaattaccc gataagtctg attttgcaaa   1693320
tcaatttcta ctactgctgt tacggactta tctttatttt gacgtttgat tacaatgctg   1693380
tgagctgttg gtgtctctat ctcagtagtc ccttctagat caaaggcttc tgaacggtta   1693440
cggaaagaaa atagattgag aagggccttc acaacaggtc gttgcacttc ttttgctatt   1693500
tcctcgttgc tatagtaatg acgattaata tttcgacctt ctttagtttc ttctaataat   1693560
ttcaagtcat tcttgcctgc taatagaccc acatagtaaa tctgaggaat acctggggca   1693620
aaagcttgaa ttagacgagc gagaaaatac ttgacatcat catctccaag cgctgaatag   1693680
taggttgaat tgatttggta gatatctaag ttgttatact cggcactaga gtacttacgt   1693740
ttgacattgg ctccaacctt atagagttca tttgaagcat agtcaatctc ctcatcggtc   1693800
aggatatcct tgacatctac tactccaatc ccatcatggg tatctagcgt cgtaaattgc   1693860
ttcatcgggc tcatctttaa ccacttagcc aaacgctctg ttctggaact gtaaagagta   1693920
taaagtgtca ccattggaag agcaaaatca taaacatagt aatcatggtc tgctatttta   1693980
aactgaatcg aatagtgttc atgaatctca ggtaaaagct ctgtcccata ctcagcagcg   1694040
atatctcgaa ctttgtccaa taaatcccaa atatctggtt ccacaaagaa atcattagta   1694100
tccaatttct tcactgcata agcaaaggca tctagacgaa tcaaatcaca cccattactt   1694160
gccaagtgct gaatggtctt acggataaat tccatagtta cttctttggt cacatcaaga   1694220
tcaatctgct cctcaccaaa ggtattccac aaatgttcca ctgaaccatc ttcaaacaca   1694280
atctcttgct ttggtgcacg atccttacgc ttgtaaatta aatctacatc agactgtgtc   1694340
ggacggtttt ctggccaaaa cttatcccag tttaaaaaga gagctttaaa ttcactggct   1694400
tcatgttttt cttgatagtc cttataatac ttggattgac gagaaatatg attaatcata   1694460
aaatcaaaca taagataata tttctcacct aaacgcttca catcctccca atcaccaaaa   1694520
gctgagtcca cttcgtcgta gtcaactggc gcaaatccac gatcaactgt tgatgggaaa   1694580
aatggtaaaa ggtgaactcc tccaatagca tctccaaaat gctcttccaa attatcatat   1694640
aagtctttaa gattatttcc aaggctatca gaataggtaa tcaacatggt tttattttga   1694700
attggcatca ttactctcct ttttctaatt gaagccaagt ctcatatgat ctggcttcat   1694760
aaataaaatt cattttaaat ctctatttat catcaaactc gtactaatat agactgtgat   1694820
aaacaaagta ctactttctt gttttctgca tagaattatc aacaagctaa actcttcctc   1694880
tgtgtcaaag actatagatt ccatgagctc ttcttatact cttcgaaaat ctcttcaaac   1694940
cacgtcagct tcaccttgcc gtaggtatgg ttactgactt cgtcagtttc atccacaacc   1695000
tcaaaacagt gttttgagca acctgcggct agcttcctag tttgctcttt gattttcatt   1695060
gagtattact tcactgcccc gttgctcatt cctgaaatga tatggcgttg gaagaagaga   1695120
tagacaatgg tgatactgat aatgccgacc acgtaagagg caaagcttgg tccgtagtcg   1695180
ttgaaatatt ggcctgcgta gttgtattgg aacaaaggca gagtccacat tttggaatcc   1695240
cggttcaaga caaggagtgg caacatgaag tcattccaga accaaagggc attgatgatc   1695300
atggttgtcg catgcatcgg tttcatcatt gggaagatga tgcggaaata ggttgtaaat   1695360
tgattagccc catcgatctc tgctgcttca tccagacttt ctggaatcga gattttgata   1695420
tagccaacat agagaaagag ggtctgtgga atcgcatagg tcaagtagag caagatcaaa   1695480
ccaaaggtat tagccaaacc gagtttactc atcataaccg taatcggaat catgatgact   1695540
tggaaaggta cgaagattcc gaggattaag agggtataca tgatggtaaa ggcttttctt   1695600
ttactcatat tgcgagcgat ggagtaggct gccataggga taaagatcat tactgcaagt   1695660
aaagacaaga cagtgatgac gacagagttc caataatagc ctccaatccc atcagctaag   1695720
agacggctaa agttgtccca tgtgaagttg gttggaaagc caaagaaatt atctacaata   1695780
tccttagtgg gtttgaagga actaaagagg gtagcaagga gcggcactaa aatcagaacc   1695840
gatcctagaa tcaatagaat gtatttgcca atcagggctt ttctttcatc ttgtttcatc   1695900
atgcttctcc tcttaaattt caaatttctt agatactctc aattggatga tcgaaatcac   1695960
tacaattaag aagaacaaga ttacggcaat ggcattggca taaccgaatt ggttgttttt   1696020
aaaggcatag ttataaacca agagcccaag tgaggttgtg gcattgtttg gaccaccacc   1696080
ggtcatggca aagacttggt caaaggcagt cagcccacct tttagggcta ggataaagac   1696140
catagagaca cttggtagca agtaaggcaa ttcaatgttc cagaaaactt gcttgctagt   1696200
cgcaccatca atccttgctg cctctgtaat ctcagttgga atagattgca aaccagctag   1696260
gaagatgatg atgggcatag ccaccccttg ccaaagaagg acaaagacag ccgcaaagat   1696320
tgctccccac ttagtcccta aaagactggt ttggaaaaat tcaatatgaa gggcatttcc   1696380
aatcgctgga agaccgtagt tgaagacttg cttgaagatc aaagccactg tcaaaccaga   1696440
taaaacagct gggaagaaga accaagcacg gaagaaggtt tggcctttga ttttagaatt   1696500
caagacacgc gcaatgaaga tcccgagtgc aatctcacca accaccatgg caatcgcaat   1696560
gattgcggta aagccaatcg cattcatgaa ttttggatcc atgaagagga gcttaaagtt   1696620
gtttaagcca acaaatttgt agttataagt caatcctgtc cagttggtaa aactgtaaaa   1696680
ggctccttga aacatcggca catagaagaa aattgcttgt aacaagaggg ggatgaccac   1696740
aaaagcccat gcccaatatt tttgtaatac ttttttcata gtctctctac tcctaatcca   1696800
catccgcttt catcgggtta aagaaggcat tcaaatcatt gaccatgcct tgtttatcac   1696860
cggtcaagac atagttcatg gtcaaggtat ggaagtctgc ttcactggtc cagtattgtt   1696920
gcaaccagac caagtgacga tccgtaaagg catattcggt cataccagca agcggtgaat   1696980
cttctcctgc ttgtttgacc ccttcgatcg ctgttggaga tccgtccaca tcgtagtatt   1697040
tttgcatgac ttctggacgg gtcatatatt ccacaaaggc attggcttct tttggatgtt   1697100
tggtggtggc tgagatagac catgccaagt ctcccgcacc aacggttaag ctttgtcctt   1697160
tttcttttcc tggaatcatg aaggtcccaa tcttaaagtt cggtttttgt tcattaatcg   1697220
ctgtgatcgc ccaagaccca tttggtgtca tgaggacatc cccacgtgcg aaggctccga   1697280
taacatcggt atagccagca ccttcccagt tcttttgctt agatccattg atgcgaagga   1697340
tgtccatgac cttgatatca tctttcataa tcggatccga caatttaatg gcatttggtt   1697400
gagaataacg aaggtattga tttgcttctt ttcctccacc tgttgctgtc gcaaaggcta   1697460
attgattgta accattgagt gtccaagcat ctgcacctgc aattccaaat ggtgtttgtc   1697520
ctttagcaac gatatctttg actaactgtt caaattcatc ccaggtttca ggaaccttca   1697580
agcccagttc ttcgaattta tctttgttgt agtaaattcc ataagcatta gctgtaaaag   1697640
gaacgttgta aactttttcg tttacagcat atttttcagc gtagccattt ttcacgcgtt   1697700
tcaggtagtc tttgttgctc aaatcttcaa aaacacctgc ttttgcccat tcttgcagtt   1697760
cgatggactg tgggtaaata ttgaccacat caggcacatc tcctgcgaga acgcgtgtct   1697820
tcaatacttc accagcattt ggtacattga cgactttgac cttgatctta gggttttcct   1697880
tctcaaaatc acgagtgatt tcttccaagg ttttggtcat ttcttttttc tggttgaaat   1697940
actcgatggt cactgtgcca tccgcagatt taccatagtt ggagcaagcg ccgagcccaa   1698000
acaaagctaa acctgtagtt gcaagaagtc cgattttttt ataccattcc attagaaagc   1698060
ctcctttata aatttataca cccttattga actgcacccc aaaagttaga cagaataaat   1698120
ctaacttttg gggtcagtac atatcatagt tttctaaaaa tatactgtct actcaaaaaa   1698180
tctccttggg ataagataac agttaagccc gcatacatta gttctgcacc tgagtaaact   1698240
tcgccatttt cctgtaattt atatagtccc tcttcatcca aatcttttaa ttttaaagtt   1698300
gtttccatgg tctctacaac agataaaacg cgaacgtagg ttacaatcgt ttgatttccg   1698360
taattaaatt gtacagctgc ttcattggat acagtatcag gattaattag tctatactgc   1698420
tgtcctaact gaactactgg tcgtaattct ttatacaagt tcacctgatt agcaatcgta   1698480
gctttctctt catctgataa atttgtcaaa tcaagttcat agcccaaatt tcccatcatt   1698540
gctacaaggc cacgtgtttc taatggtgtc attcgtccca tctgatgatt cggtactgct   1698600
gacacatgag cccccataga aatggttgga tagagatagg atgaaccgta ttgaattggt   1698660
aaacgtgcaa tggcatcagt attatcacta gcccagactt gtgggaaata gcgcatcata   1698720
ccaagatcat ttcgtccacc accaccagag caggactcaa agagaatatg gctgtgcttc   1698780
tctgtcagat aagaaacgag ttcataaagc cccagcatgt actgatgaga ttgcatctgt   1698840
gtctctagat aagttaatcc attccctagc ttagtgatat tgcggttcat atcccattta   1698900
atgtaatcaa tatcatgata aaataggagt tgatctaaga cacttttcaa gtattctact   1698960
acctgaggat tggcaagatt aagtactaat tgattccgag aataagtatg ctcatagcca   1699020
ggaacctgaa tagcccagtc aggatgttga cgatacaaat cactatctac agaaatcatt   1699080
tcgggttcta accaaagtcc aaactgcaaa cctctttcat ggatagctga aatcagactt   1699140
tctagacttc cacccagttt ttcctcatta acaacccaat cacctaaagc acgattatca   1699200
tcaaaacgat tgccaaacca accatcatct aatacaaaaa gttcaatgcc aactttctta   1699260
gcttcatctg ctaactctaa cagtttttct ctctgaaagt caaagtaagt agcttcccag   1699320
ttattgatta gaattggacg ttctttttta gaaaattcac ttagcataat gtgcttcagt   1699380
acaaaattct gactttcatg actaatacca gttaatccct gatctgaatg agtcactaaa   1699440
gctaccggtg tttcaaagta ttcctcagga gctaacttcc aagaaaagtt ttctggatta   1699500
atgccaatag ccacccgaac ttcattcaat tgattttttt gaacaaaagc ttcaaagttg   1699560
ccactataca ttagttgaat agcaaacaca ttcccagcat cctctgtgac tccttgttcg   1699620
catagtagaa gagctggtgt ttgagcatga ccagaagcac ctcggtttga actaatcgaa   1699680
aagattcctt gttctacctg ttgacgtcta acagtctttt cacgagcata agcaccctgc   1699740
agagttacta tttcgtaatc tgcagctgga aaatcagcca taaaagaaaa atctttatgg   1699800
atgacaactt cctgattact attattatct aatttactgt agctagcaat agtcgcatca   1699860
ttattaaaag tagtataata caaagtcaga ctaagttgag ccttagaatc ttctaacatt   1699920
aagacaagag tctctgtatc gtccatgcta tgtggagaag gtaagccctg tggaccattc   1699980
tgacctttta aaatctttgc ttctacaaat cgaaagtctg ttacttcagt tacactatgc   1700040
tgaacctgta tggttggttt cctaaaatct cctaagccat gttgtccaaa aatctgtcgc   1700100
tgagtatcta aactaaaggt tcgattagta gccgttggat ttcctgaaaa ggcatggtct   1700160
cgttcataaa cactattgga acctttatag ttcttaatag tctttcctaa atgtttcaaa   1700220
agtaagtagc catttcgatt ttcaataatc aaacttagat ttttactctc aacataaaat   1700280
agattattct ctatcctaac tcccatttac ttcacctcat cactttattg attatatttt   1700340
atcacctgaa atcgctttcc aaaatagaaa aatgtctcaa gaatatggta aaatgttagg   1700400
taggaggtag cacatgttag ttttttcaga ataccagact ggaacaatcg accttgccct   1700460
aagcttttat ggatatgagg aatgcacacc taattactct tttggtccag ccattcgtga   1700520
tacatacgtt ctacattaca ttactaaagg acaaggaaaa tttcattaca agggtaaaat   1700580
tgttgattta aaagaaggag atttctttct attaaaacca gaggaactaa ccttttatca   1700640
agcagatagt aaagaacctt gggcctacta ctggttagga atcactggag ggaaagcccc   1700700
tgattatttt gctctttccc aaatttctga tcaatcctat ctcatccaat ctgaaacttg   1700760
tcatacccag actactgcaa aactcatctc agacattgtc cgcttcgctc agattacaaa   1700820
atcaagtgaa ttagctcaac tccatatcat gggacaactt catgaactga tgtttcatct   1700880
gggaactatt gctcccaatc agaaaaaaaa gaatatttca tcaacccacc aactctatct   1700940
tgaatgcaaa cgattaattg atagccacta tcctcaatca cttacaattc aagatttagc   1701000
aaaagaacta tccgttcaca gaagctactt atcaagcgta ttcaaagaat ttaatacctt   1701060
atcacccaaa gaatacctac tctacgttcg aatgcaccga gctagacaac ttctcgaaaa   1701120
tacccaagag tccatcaagg taattgcata ctcggtaggt ttttcagatc cactccattt   1701180
ttcgaaagct tataaacaat actttaatca gactccaagt catacaagaa aagaatactc   1701240
tcaataccaa ctagtaagaa aggcaacatt atgaaatcct accaagctgt ctaccaaatc   1701300
ctatctaaag aaaccgacta tatcagcgga gaaaaaatcg cagaaaaact atccctaagc   1701360
cgaacagcaa tttggaaagc catcaagcga ctagaacaag aaggcattga aattgatagt   1701420
atcaaaaata gaggatataa actgatgaat ggtgacctta ttcttccaga gattctagaa   1701480
gaaaatcttc caattaaagt cagctttaaa cccgaaacaa aatcaacaca actagatgca   1701540
aaagaagcaa ttgatttagg ccatgaagca aataccctct atctagcttc ctatcaaaca   1701600
gcaggccgag gccgttttca acgttccttc tactcaccac aaggtggtat ttatatgaca   1701660
ctccatctta aaccaaatct cccctatgac aaattaccat cctacacact acttgtagct   1701720
ggagctgtct acaaagccat taagaaccta actttaatag atgtcgacat aaaatgggtc   1701780
aatgatatct atctaaacaa tcataaaatt ggaggaatcc ttactgaagc aatgacctct   1701840
gtagaaactg gcttagtcac agatatcatt attggagtag gtatcaattt cactattaaa   1701900
gacttccctc aggaattaaa agaaaaagct gccagcttat ttaaagctac agctcctata   1701960
acaaggaatg aattgatcat agaaatctgg cgtgctttct tcgaaacacc agcagaagag   1702020
ctattatacc tatacaaaaa acagtcattc attctaggaa aagaagtcac tttcacacta   1702080
gagcaaaaag actacaaggg acttgctaaa gacatctcag aaaatggaaa acttttagtt   1702140
caatgtgata acggaaaaga aatctggcta aatagtggcg aaatttctct caatagttgg   1702200
aagtaaaata acacaattat aatataaacg atataaaaat aacttcagat tagtaattca   1702260
attaagtttt acggatctga agttttattg gctctaaaaa taaaaaagag agttacagac   1702320
tctcattaaa acggagaata agggattcga acccttgcgc cagttacccg acctaacgat   1702380
ttagcaaacc gtcctcttca gcctcttgag taattctcca attaatgggc acgagtggac   1702440
tcgaaccacc gacctcacgc ttatcaggcg tgcgctctaa ccacctgagc tacgcgccca   1702500
agttaaaaaa cttggtaatt tgaacaaagt tcaaagcggg tgacgagaat cgaactcgcg   1702560
acaacagctt ggaaggctgt agttttacca ctaaactaca cccgcataaa tactatcaat   1702620
aaaatggcgc gagacggaat cgaaccgccg acacatggag cttcaatcca ttgctctacc   1702680
aactgagcta ccgagcctta ttgcgggagc aggatttgaa cctacgacct tcgggttatg   1702740
agcccgacga gctaccgagc tgctccatcc cgcgttaata atataaaagg aggatgtggg   1702800
attcgaaccc acgcacgctt ttacacgcct gacggttttc aagaccgttc ccttcagccg   1702860
gacttgggta atcctccaat attcaaatgg accttgtagg acttgaacct acgaccactc   1702920
ggttatgagc cgagagctct aaccagctga gctaaaggtc cgacaagatc attatagcgg   1702980
cgaaggggat cgaacccccg acctcccggg tatgaaccgg acgctctagc cagctgagct   1703040
acaccgccat gaatcgggaa gacaggattc gaacctgcga caccttggtc ccaaaccaag   1703100
tactctacca agctgagcta cttcccgagt taaatagaaa aatgcaccct agaggagtcg   1703160
aacctctaac cgcctgattc gtagtcaggt actctatcca gttgagctaa gggtgctcca   1703220
tattatgccg aggaccggaa tcgaaccggt acgatcgtta ccaatcgcag gattttaagt   1703280
cctgtgcgtc tgccagttcc gccaccccgg cctctctaag cgaacgacgg gattcgaacc   1703340
cgcgaccccc accttggcaa ggtggtgttc taccactgaa ctacgttcgc actgttttct   1703400
tctatctaaa aatgccggct acatgacttg aacacgcgac cctctgatta caaatcagat   1703460
gctctaccaa ctgagctaag ccggctcatt tgttatatct taatgcgggt taagggactt   1703520
gaacccccac gccgttaagc gccagatcct aaatctggtg cgtctgccaa ttccgccaaa   1703580
cccgcatata tgacccgtac tgggctcgaa ccagtgaccc attgattaaa agtcaattgc   1703640
tctaccaact gagctaacga gtctaaaata acttgcgtta ccttaaacgg tcccgacggg   1703700
aatcgaaccc gcgatcttcg ccgtgacagg gcgacgtgat aaccgctaca ctacgggacc   1703760
tttgggagtt aacgggatcg aaccgctgac cctctgcttg taaggcagat gctctcccag   1703820
ctgagctaaa ctccctagag ctaagcgact tccctatctc acagggggca acccccaact   1703880
acttccggcg ttctagggct taacttctgt gttcggcatg ggtacaggtg tatctcctag   1703940
gctatcgtca cttaactctg agtaatacct actcaaaatt gaatatctat tcaatttaag   1704000
aaaaccgttc gctttcatat tctcagttac tttggataag tcctcgagct attagtatta   1704060
gtccgctaca tgtgtcgcca cacttccact tctaacctat ctacctgatc atctctcagg   1704120
gctcttactg atatataatc atgggaaatc tcatcttgag gtgggtttca cacttagatg   1704180
ctttcagcgt ttatcccttc cctacatagc tacccagcga tgcctttggc aagacaactg   1704240
gtacaccagc ggtaagtcca ctctggtcct ctcgtactag gagcagatcc tctcaaattt   1704300
cctacgcccg cgacggatag ggaccgaact gtctcacgac gttctgaacc cagctcgcgt   1704360
gccgctttaa tgggcgaaca gcccaaccct tgggaccgac tacagcccca ggatgcgacg   1704420
agccgacatc gaggtgccaa acctccccgt cgatgtgaac tcttggggga gataagcctg   1704480
ttatccccag ggtagctttt atccgttgag cgatggccct tccatacgga accaccggat   1704540
cactaagccc gactttcgtc cctgctcgag ttgtagctct cgcagtcaag ctcccttata   1704600
cctttacact ctgcgaatga tttccaacca ttctgaggga acctttgggc gcctccgtta   1704660
ccttttagga ggcgaccgcc ccagtcaaac tgcccgtcag acactgtctc cgatagggat   1704720
cacctatctg ggttagagtg gccataacac aagggtagta tcccaacagc gtctccttcg   1704780
aaactggcgt cccgatctct tagactccta cctatcctgt acatgtggta cagacactca   1704840
atatcaaact gcagtaaagc tccatggggt ctttccgtcc tgtcgcgggt aacctgcatc   1704900
ttcacaggta ctaaaatttc accgagtctc tcgttgagac agtgcccaaa tcattacgcc   1704960
tttcgtgcgg gtcggaactt acccgacaag gaatttcgct accttaggac cgttatagtt   1705020
acggccgccg tttactgggg cttcaattca taccttcgct tacgctaagc actcctctta   1705080
accttccagc accgggcagg cgtcaccccc tatacatcat cttacgattt agcagagagc   1705140
tgtgtttttg ataaacagtt gcttgggcct attcactgcg gctgacttta agtcagcacc   1705200
ccttctcccg aagttacggg gtcattttgc cgagttcctt aacgagagtt ctctcgctca   1705260
cctgaggcta ctcgcctcga ctacctgtgt cggtttgcgg tacgggtaga gtatgtttaa   1705320
acgctagaag cttttcttgg cagtgtgacg tcactaactt cgctactaaa cttcgctccc   1705380
catcacagct caatgttata gaattaagca tttgactcaa ttcacacctc actgcttaga   1705440
cagactcttc caatcgtctg ctttagttag cctactgcgt ccctccatca ctacatactc   1705500
tagtacagga atatcaacct gttgtccatc ggatacacct ttcggtctct ccttaggtcc   1705560
cgactaaccc agggcggacg agccttcccc tggaaacctt agtcttacgg tggacaggat   1705620
tctcacctgt ctttcgctac tcataccggc attctcactt ctatgcgttc cagcactcct   1705680
cacggtatac cttcatcaca catagaacgc tctcctacca tacctataaa ggtatccaca   1705740
gcttcggtaa attgttttag ccccggtaca ttttcggcgc agggtcactc gactagtgag   1705800
ctattacgca ctctttgaat gaatagctgc ttctaagcta acatcctagt tgtctgtgca   1705860
accccacatc cttttccact taacaattat tttgggacct tagctggtgg tctgggctgt   1705920
ttccctttcg actacggatc ttagcactcg cagtctgact gccgaccata attcattggc   1705980
attcggagtt tatctgagat tggtaatccg ggatggaccc ctcacccaaa cagtgctcta   1706040
cctccaagaa tctctaatgt cgacgctagc cctaaagcta tttcggagag aaccagctat   1706100
ctccaagttc gtttggaatt tctccgctac ccacaagtca tccaagcact tttcaacgtg   1706160
ccctggttcg gtcctccagt gcgtcttacc gcaccttcaa cctgctcatg ggtaggtcac   1706220
atggtttcgg gtctacgtca tgatactaag gcgccctatt cagactcggt ttccctacgg   1706280
ctccgtctct tcaacttaac ctcgcatcat aacgtaactc gccggttcat tctacaaaag   1706340
gcacgctctc acccattaac gggctcgaac ttgttgtagg cacacggttt caggttctat   1706400
ttcactcccc tcccggggtg cttttcacct ttccctcacg gtactggttc actatcggtc   1706460
actagggagt atttagggtt gggagatggt cctcccagat tccgacggga tttcacgtgt   1706520
cccgccgtac tcaggatact gctaagtaca aagactattt taaatacgag gctattactc   1706580
tctttggctg atcttcccaa atcattcttc tataatcttt gagtccacat tgcagtccta   1706640
caaccccgaa gagtaaactc ttcggtttgc ccttctgccg tttcgctcgc cgctactaag   1706700
gcaatcgctt ttgctttctc ttcctgcagc tacttagatg tttcagttca ctgcgtcttc   1706760
ctcctcacat ccttaacaga tgtgggtaac aggtattacc tgttgggttc ccccattcgg   1706820
aaatccctgg atcatcgctt acttacagct acccaaggca tatcgtcgtt tgtcacgtcc   1706880
ttcgtcggct cctagtgcca aggcatccac cgtgcgccct tattaactta accttatttt   1706940
ctgacctttc agtcataaac tcttattaat actacagcgt tttcggttta ttttcttgtt   1707000
actatttgat atagatattc aattttcaat gtgcattact tggtgatctc tcaccaatgg   1707060
agcctagcgg gatcgaaccg ctgacctcct gcgtgcaaag caggcgctct cccagctgag   1707120
ctaaggcccc acaagacctc tcaagactaa acaagaccaa tgcgcagttc cttatcctta   1707180
gaaaggaggt gatccagccg caccttccga tacggctacc ttgttacgac ttcaccccaa   1707240
tcatctatcc caccttaggc ggctggctcc ttacggttac ctcaccgact tcgggtgtta   1707300
caaactctcg tggtgtgacg ggcggtgtgt acaaggcccg ggaacgtatt caccgcggcg   1707360
tgctgatccg cgattactag cgattccgac ttcatgtagg cgagttgcag cctacaatcc   1707420
gaactgagac tggctttaag agattagctt gccgtcaccg gcttgcgact cgttgtacca   1707480
gccattgtag cacgtgtgta gcccaggtca taaggggcat gatgatttga cgtcatcccc   1707540
accttcctcc ggtttattac cggcagtctc gctagagtgc ccaactaaat gatggcaact   1707600
aacaataggg gttgcgctcg ttgcgggact taacccaaca tctcacgaca cgagctgacg   1707660
acaaccatgc accacctgtc acctctgtcc cgaaggaaag ctctatctct agagcggtca   1707720
gagggatgtc aagacctggt aaggttcttc gcgttgcttc gaattaaacc acatgctcca   1707780
ccgcttgtgc gggcccccgt caattccttt gagtttcaac cttgcggtcg tactccccag   1707840
gcggagtgct taatgcgtta gctacggcac taaaccccgg aaagggtcta acacctagca   1707900
ctcatcgttt acagcgtgga ctaccagggt atctaatcct gtttgctccc cacgctttcg   1707960
agcctcagcg tcagttacaa gccagagagc cgctttcgcc accggtgttc ctccatatat   1708020
ctacgcattt caccgctaca catggaattc cactctcccc tcttgcactc aagttaaaca   1708080
gtttccaaag cctactatgg ttaagccaca gcctttaact tcagacttat ctaaccgcct   1708140
gcgctcgctt tacgcccaat aaatccggac aacgctcggg acctacgtat taccgcggct   1708200
gctggcacgt agttagccgt ccctttctgg taagataccg tcacagtgtg aactttccac   1708260
tctcacactc gttcttctct tacaacagag ctttacgatc cgaaaacctt cttcactcac   1708320
gcggcgttgc tcggtcagac ttccgtccat tgccgaagat tccctactgc tgcctcccgt   1708380
aggagtctgg gccgtgtctc agtcccagtg tggccgatca ccctctcagg tcggctatgt   1708440
atcgtcgcct tggtgagccg ttaccccacc aactagctaa tacaacgcag gtccatctgg   1708500
tagtgatgca agtgcacctt ttaagcaaat gtcatgcaac atctactctt atgcggtatt   1708560
agctatcgtt tccaatagtt atcccccgct accaggcagg ttacctacgc gttactcacc   1708620
cgttcgcaac tcatccagag aagcaagctc ctccttcagc gttctacttg catgtattag   1708680
gcacgccgcc agcgttcgtc ctgagccagg atcaaactct cattaaaaag tttgagttct   1708740
tactcatttc tgtcactgac agatttattg tttttttcat tgttcagtac tacaacttac   1708800
gttgtagcgc cctgcacatt ggttcgtctt gttcagtttt caaaggtctt tgtcacttgc   1708860
ttctctcaag cgacaactat attagtatat cacaactgct ttcgcttgtc aacacttttt   1708920
tgaagatttt taagtttttt taaacttttt ttcatcaagt ggtcctgacg caacatacca   1708980
tagtccgtac gggattcgaa cccgtgttac cgccgtgaaa aggcggtgtc ttaacccctt   1709040
gaccaacgga cctgagttgt tattttcaac tcttactatt atacagtctt ttcaaacttt   1709100
gtcaactact tttttaaact ttttttatta attttacaac agcttcagtt cgagctgtat   1709160
gtgggaacat atcgaccgac tggatataat gaagatcata gacttctact aagcgtacca   1709220
aatcacgagc caaggtcgaa acattacaag aaatataaac cattttttct ggtacataag   1709280
taagaatagt atctaataac ttatcatcca gacctgtacg tggtgggtca acaatcaaag   1709340
catctgctcg gtagccttcc ttgtaccaac gaggaataat ctcttctgcc gttccagctt   1709400
cataatgagt attgtcaaat cccattcttt tagcatttcg cttggcatct tcaatagctt   1709460
ctggaataat atccatacct ctgagtgttt ttactttctt tgcaaaggca aatccaatcg   1709520
ttccaactcc acaataagcg tcaatcaaat ggtcttcttt atcaacatcc agcgctttta   1709580
ctgcttcgct atagaggact tctgtttgct caggatttag ttgataaaaa gctcgagggg   1709640
atagtgaaaa ttcataattg agtacacctt cttgaatact ctcttgcccc cagataatct   1709700
ctgtcttttc accatatatc tcactggttt tagctgtatt tgtattaaca gctactgtca   1709760
caacttctgg gaaatcttta accaactctt ttaccaattg agttaaatta agctggcggt   1709820
ttgtaacaat aataatctga acctgtccgg tctttctcgc gcgtcggacc ataatagtac   1709880
ggacacctag aacttttctc tcatccgtga ttggaatctg gtgataagta agtaattctg   1709940
ctaagcgatt agcaatcact tgggtttcct tatcttgtac caggcagtct ttcaactcta   1710000
ctaaatagtg agagttttgt gcatataagc ccgccttgac ctgattttta aattttcgag   1710060
tctgaaattg taacttagct ctgtaatatt ttggttcctg cattccaata gttggacgaa   1710120
tttcataatt ttcatatcct gcaggagcaa attttttcag cgcttgatga agtaagtccg   1710180
tcttgaactc cagctgctta tcataatgca ggtgcatgat ttggcagcct ccgcattcat   1710240
tataaatagt acaagatggc acaattcgaa atttagactt cttgttgacc ttcagtaatt   1710300
ttgcttcaac aaagttgcgt ctaatagaag taatctgaca atagatatct tcgcctttga   1710360
gagctcctgg tacaaagact aatgtttttt ggtaaaagcc gattccctca ccgttaattc   1710420
ccatgcgctt gatttttaat ggtatttttt gtttcacttt cagattcata cccctatctt   1710480
atcacatttt gagttataat agagctatga aaatcacaaa acttgaaaag aaaaaaagac   1710540
tctatctgat ggagcttgat aatggcgaca aatgctatat caccgaagac acaattgttc   1710600
gttttatgtt atcgagagat aaggtgataa gcgaagagga attgaaagag attcaagact   1710660
ttgctcaatt ttcttatggt aagaatctgg ccctctacca cttatccttt aaagcacgta   1710720
ctgaaaaaga ggtcagagaa tatctgaaaa aatatgatat taatgaaaac atcgtttctc   1710780
aagtcattgc taatcttaaa gaagagaagt ggattaatga tagccagtac gcttatgcta   1710840
tcatcaatgc caatcaactt tcaggagaca agggacctta tgtactgact cagaaattag   1710900
cacaaaaagg aatttcaaaa tctactatag aagaaatctt gaatgatttt gatttttcgg   1710960
aagttgctca acgtgtagcc aataaactat tgaaaaaata tgagggaaaa cttccagctc   1711020
gtgccctgca agataagatt atccagaact tgactaacaa gggcttctct tattttgatg   1711080
ctaaaattgc ctttgacgaa ttggatagtc aagttgatga agaaacgact caggaactca   1711140
tcttcaagga acttgataag caatatacta agtatgcccg aaagtatgaa ggatacgaac   1711200
tgaagcagcg tttaactcaa gttttagcac gaaagggcta cgatttttcg gatatagcaa   1711260
gcgctcttag agaatatctt taatatttcc aagtgaaatt cacagatttt gggtaatttt   1711320
atggtacaat agtaaatgat aaacttataa attgtagaaa gttggttagt tatgaagctt   1711380
ccaaaagaag gcgactttat tacaattcaa agttataagc atgatgggag tctccaccga   1711440
acttggcggg acaccatggt actaaaaaca acagaaaacg ccattattgg tgtcaacgat   1711500
catacacttg ttaccgaaag tgatggtcgt cgttgggtca ctcgagaacc ggctattgtt   1711560
tactttcaca agaaatattg gtttaatatc attgccatga ttcgtgataa tggaacttct   1711620
tactattgca atatggctag cccctactat ctggatgaag aagcactgaa gtatattgat   1711680
tacgatttgg atgttaaaat ttttacagat ggggaaaaac gtctcttgga cgttgaagag   1711740
tacgagcgtc acaaacgcaa aatgaattat tctgatgact tggactatat tttaaaagaa   1711800
catgtcaaaa ttcttgttga ttggattaac aatggacgtg gtcctttctc agaagcctat   1711860
gtaaacattt ggtacaagcg ctatgtagaa ctaaagaatc ggtaaagttg tcaaaggtca   1711920
ggaacaaaat cctgaccttt tttggtagta taaaataaat tgtgtaaaca caaaaaggaa   1711980
taaatctatt atagcagagt tacaacacat tactagaaag agatttatgc agaattcgta   1712040
aaatatataa aacaaataga tatactgtta ttttttaatg tctttattcc ttgtaagttt   1712100
acaacaaact tatatcgttt aatacaaaaa atacgaaaat gattagtata aaaaatacag   1712160
gtcaacttcg tatcaaaaac atttttttgt atttccacat agcatcaatc atttagtaca   1712220
atattttaaa aacaatatct caacagagaa aatgctattt aatctatcag ctcatttaat   1712280
cgtttttgaa aatataaagc aatactttta gattcaataa actcaaaata ttttatgaca   1712340
ttgtccattt gtttaattcc agattcttta gattctgtca ggtatatttt atatccttct   1712400
acaaatttga atgtagattt ttcaaaaact tttgtgtcat cctttaataa tttttttaat   1712460
ttcatttcaa agtagtctgc atatattaga tgtgaatttt cggctctata atatttgtag   1712520
tgggtaaatc ccttatagat attatggagc ctattttgtt gtagaaaaaa agtcccatat   1712580
gacctataat gaaaagcgac aaaacaactc attagaaaga ttcatatgga acaattacat   1712640
tttatcacaa aactgctcga tattaaagac cctaatatcc agattttaga catcatcaat   1712700
aaggatacac acaaggaaat catcgccaaa ctggactacg acgccccatc ttgccctgag   1712760
tgcggaaacc aattgaagaa atatgacttt caaaaacctt ctaaaattcc ttatcttgaa   1712820
acgactggta tgccttctag aattctcctt agaaagcgtc gtttcaagtg ctatcactgt   1712880
tcaaaaatga tggttgctga gactcccctg gtaaagaaaa atcaccaaat ccctcgtatc   1712940
atcaaccaaa agattgctca aaagttaatt gaaaaaattt ctatgactga tattgcccat   1713000
cagctggcca tttcaacttc aactgtcatt cgcaagctca atgactttca ctttgagcat   1713060
gatttttctc ggcttccaaa gattatgtct tgggatgagt atgccttcac taagggaaag   1713120
atgagtttca ttgcgcaaga ttttgataat cttaatatta tcactgttct tgaaggcaga   1713180
acacaagctg tcatccgaaa tcactttctt cgctacgata gagccgttcg ttgtcaagtg   1713240
aaaatcatta cgatggatat gtttagtcct tactatgact tggctaaaca gcttcgcttt   1713300
caaatttcta ggctcaggct gaaacagtct cccagactgt ttcactcccg aatgctaaaa   1713360
tcgtgttgga tcgctttcac attgtacaac atcttagccg tgctatgagt cgtgtgcgtg   1713420
ttcaaattat gaaccaattg gatcgaaaat cccatgaata caaggctatc aagcgctact   1713480
ggaagctcat acaacaggat agccgtaaac tgagtgataa gcgattttat cgtcctactt   1713540
ttcgtatgca tttaaccaat aaagagattt tagacaagct tttgagctat tcacaagact   1713600
tgaaacatca ctatcagctc tatcaactct tgctgtttca ctttcagaat aaggaaccgg   1713660
agaaattttt cggacttatt gaggacaatc ttaagcaagt tcatcctatt tttcagactg   1713720
tctttaaaac cttcctcaaa gataaagaaa agattatcaa cgcccttcaa ctacactatt   1713780
ctaacgccaa accggaagcg accaataatc tcatcaaact tatcaagcgc aatgcctttg   1713840
gttttcgaaa ctttgaaaac ttcaaaaaac ggatttttat cgctttgaac atcaaaaaag   1713900
aaaggacgaa atttgtcctt tctcgagctt agctgacttc aacccactac agttgacaaa   1713960
gagcctataa aaagaagggt tagtcattcc ctccttttgt gttttttata agttgttttc   1714020
tatagaaagc ttacatcatc ccgcccatca tgcttggatc cattgctgga gctggggcta   1714080
ctggttctgg tttattggct acgactgctt ctgttgtcaa aatcaagctg gctacagatg   1714140
ctgcattttg tagggctgaa cgactcactt taactggatc aatgatacct tgatcaatca   1714200
tgttaaccca ctcgccagtt gctgcgttaa atcctatacc aagctcagca tttttcaaac   1714260
gatcgataac gatagatcct tcaaatcctg cattgtgagc aatttgacga acgggttctt   1714320
ccaaagcacg gagaacaata ttacgtcctg ttgcttcatc tcctgtcaat tccaaggtag   1714380
caacagctgg aatcacattg gcaagagctg ttccaccacc tgcaacaata ccttcttcaa   1714440
cagctgcacg agtagcgttg agggcatctt caatgcggag tttcatttct ttcaactcag   1714500
tttcagttgc ggctccaacc ttaataaccg ctacaccacc tgacaatttg gccaagcgtt   1714560
cttgcaattt ttcacggtca aattcagaag ttgtagtttc gatttgagac ttgataaccg   1714620
caacacggtg agaaatcgct tcaggatttc ctgcaccttc tacaataacc gtgctatctt   1714680
tgtccacggt cactctcgct gcttgaccaa gagcttcaat tgtcgcatct ttcaactcaa   1714740
gaccaaggtc ttctgtgata actgttccgc ctgttaagat ggcgatatct tcaagcatgg   1714800
ctttgcgacg gtcaccaaaa ccaggtgcct tgactgctac tacgttgaag gttccacgaa   1714860
tcttgttcaa aacaagagtt ggaagagcct cgccatccac atcatccgca ataatcaaga   1714920
gtggacgatt gctttggaga atgctttcca aaagtggcaa gatttcttgg atattggaaa   1714980
ttttcttgtc tgtaatcaaa atgtacggat tttcaaggtc agccaccatt ttttcgctat   1715040
ctgtcaccat gtactgtgaa aggtaaccac ggtcaaactg cattccttct acgacttcaa   1715100
gctctgtttc cataccacgt gactcttcga tggtgatgac accgtctttg ccaacttttt   1715160
ccattgcttc agagatgtac tcaccaactt tttcagaacg agaagatacg gctgcaactt   1715220
gagcgatagc ttctttattg gcaacaggga tggcgttgtt tttcaaagct tcaactgctg   1715280
cggcaactgc tgtttcaatc ccacgacgaa taccgattgg atttgcacct gctgtgacgt   1715340
ttttgattcc ttcacggacg atagcttggg tcaagactgt tgcagtcgta gttccgtcac   1715400
ctgcgatatc attggtttta gaagctactt ctgatactaa cttagcaccc atattttcaa   1715460
aatggtcttc caattcgatt tctttggcaa tggtcacacc gtcattggta atcaagggtg   1715520
aaccgaatga cttttcaaga acgacattgc gaccttttgg tcccaaggtt actttaacag   1715580
tgtctgcaag gatatcgaca ccacgaacca tggctgaacg ggcatctgat gaaaatttaa   1715640
tttcttttga catacttact ttctccttct attcctcaat gattgccaaa atgttagctt   1715700
cgcctacgat gatgtacttt tcatcgccat ctttgacatc aagacctgcg tgggcttcaa   1715760
ctaagacacg atctccagtt ttaacacttg gagcaaccaa gtcaccgttc aaggtacgaa   1715820
caccttgtcc agtagccaca acttgagctg ttttggtttt ttcttgggct gagcctgcaa   1715880
ggacaaagcc tccaacagtt tgttcttttt cttctatttt taagaccaca cggtccccta   1715940
atggtttcaa catctgattt cctccataat gagatagata ttattagcac tctttgaact   1716000
tgagtgctaa ttcatagttc tattgtatca cttggtcaga aataatcaag aaaaaagtct   1716060
gactttctca agataaaaag cctgagacca actcagactt tttaattctt aaaatggcaa   1716120
ttcttcctct tccaagacca aatctgccaa atcttggcct gcattatttt cacgcatagc   1716180
acgttgggca cgactttcca agagttggaa tcctgtgaca agtacttcgg tcacgtagtt   1716240
catttggcca tttttctcaa agcgacgggt acgcaattct ccatcaacgg aaatgagact   1716300
acctttggtt gcgtagcttg ccaaagtttc tgctagtctg ccccatagga ccatattgac   1716360
aaaatcagct tcacgttcac cgttttggtc tttgtaacga cggttcacag cgatagttgc   1716420
tcgcgctacc gacttgtcat tgttggtttt gtgcaattct ggtgtagacg ttaaacgtcc   1716480
aatcaagata actttattat acatattttc ttcctcctac ttatctattc gtaggaaatc   1716540
aaaaaaagtt acagaaattt gtaacttttc gagaaaattt tttatttttt atgaaccatg   1716600
aaacctgtcg cctgttgatt ggccataatg gtcatatctg taatctgaac acgacgaggt   1716660
tgactagtca catagactac tgtatctgca atatcctgag cttgcaaagc ttctattcct   1716720
tggtaaacgg acgcagctcg ttctttatca ccatgaaaac gcactgtaga aaaatctgtt   1716780
tcgacaattc caggctgaat ggtcgtcacc ttgatatccg ttgcgatggt atcaattcgc   1716840
agtccatctg aaaaggtctt aactgccgcc ttggtggctg agtaaacagc tgcaccagca   1716900
taggcataaa ttcctgcggt tgaccccata ttgataatat gaccttgatt ggcttttacc   1716960
attgctggca agaaacagcg agtgactgcc atcaaacctt tgacattggt atccaacatg   1717020
gtcagcatat ccaactcttc atagtcttga tagggagcta agccaagagc cagtcctgcg   1717080
ttattgacca ggatgtcaat ctgacctatc gtttctaaaa tatcagagca gacagtcttt   1717140
accattgtca tatccgtgac atctaggaga aaagtccaaa ctgtttgatt tggaaaagtt   1717200
tctgcaaact ccgccttaag agcttctagt ctgtctatcc gtcgtcctgt tagaacgaca   1717260
tcctcaccct gctccagata agcacgcgca atcgcttcac cgattcctga tgtcgctcct   1717320
gtaatcacaa cattttttgc catcttattt ccttctagct ggtctatcag atattaacaa   1717380
cttcttaggc agtccagtgt ttcgctgggt cgaacggtgt tccgacaact tggtcttctg   1717440
ataattcaag caccccacgt ttttgtggag catttggcag atgcaattca cgaggactgc   1717500
acatcatacc aaaactcttt tcaccacgaa gttcacctgg gaaaatgaga ttcccttttg   1717560
gcatcatagc tccaggaagc gcgacaatgg ttttcaaccc cacacgcgca ttgggagctc   1717620
ctgcaacgat ttgtacagtc ttatcacttg cgactgcaac ttggcagatg ttgaggtggt   1717680
cactatctgg atgggctacc atctcaacaa tttcacctac aacaaactta ggttccttat   1717740
cattaacaat ttcttctgta aaaccttccg cctgcaactc ttggttcaaa cgagcgactt   1717800
gctcatctgt caaaaagact tgaccgcgct ctgcaatttc aaataaactt gaaacttcga   1717860
aaatattcca agccactgtt tccccattat ctttgagaaa aacacgggct accttgcctt   1717920
tgcgctccac atccagtttg gcatctccgc tatttttcac gatgaccata aggacatcac   1717980
cgacatgttc tttattatat gtaaaaatca ttgtttcctt tttctcctat ttcagtcctg   1718040
ctaaaaagtc attgatttgt tgcttgcttt tacggtcgcg attgacaaaa cgaccgattt   1718100
ccttgtcctt ttctagaaca acaaggctag gaattccgta aacatcccag agtttggcca   1718160
aatccatata ctgatctcgg tccattcgaa taaaggtgaa ctctggattg gtctcctcaa   1718220
tctctggtaa ggcaggataa atataacgac aatcgctaca ccagtctgcc acaaaaatga   1718280
agaccttctt gcccgctttt tccactaaag atgctaattc ttctaaactt gctggctgta   1718340
tcataagact tcctcctcat agactaggtc ttcattttca tagacaaagg tataatgacg   1718400
gccatcctca aaaatgacgc caccaaccaa gctctccaga ctgctttcgt aaacttgaac   1718460
ataaagggtc gcaatttccc ccatgtcgga aaaatggtct cgcacaatct ctgtcaactc   1718520
ttcctgagtc ttcatgagct tacggtcatc tgcaactttt ttcgtagcaa gagcaaggct   1718580
tccgatacct agcagagcca agcctgccat ccacattttt ttagctttca taccattcat   1718640
tttaacacaa aaaaggcttc aggacaaatg aggaagcagc agaaaagcaa gtaaaaagcc   1718700
tcttccttta aggaaaagga cttcttatac tcaatgaaaa tcaaagacca aactaggaag   1718760
ctagccgcag gctgctcaaa gcactgcttt gaggttgtag atagaactga cgaagtcagc   1718820
tcaaaacact gttttgaggt tgtggatgaa gctgacgtgg tttgaagaga ttttcgaaga   1718880
gtattattct tattgccagg cacctaagtt gccaacgtag taactatcag gtgtgtaggt   1718940
attgcgaagc atcttacctg atgaagccag ataatactac ttgccattgt ctttgaccca   1719000
atcattcgca atcatggaac cagaagaact tacataatac cattctccct tgtcataaac   1719060
ccaagtactg actttcatgg ttcctgagca attaaaggca aaaaaactgt ccaatatcat   1719120
tcgtttttta aaagcatttg acactacatc atctacgctg tagtacatag atacatcaaa   1719180
cgtaaaagcc aaaatatcga aaaatataca acttttaaag gcagcatttc attttttaaa   1719240
gtctaacaac catagaactg aaatcagagc aaggcatcaa tttcctactc ttagtacgtc   1719300
tattttgatg gttgaagtga agattttttt atttaacgta gacaatttcc aacttcccaa   1719360
aagccacatc tccacggata atcaaggttt tgctggttgg ggctacagga gcgtcagcct   1719420
tagctgcacc aaaggaggtt tctactttca aatctacacg ccagtgttgt ggaacataga   1719480
cggttgcatt cccgaaggcc acttcaatat ttaaagttgc aaaatcacct agcatctctg   1719540
cattatcata gtagatttta gcatccccaa aagcgacttc cacttggtca tctacgagat   1719600
cttgatcttg cttatagaag gtcccgctac caaaagcgac ttccttatcc gtgacgactg   1719660
tttttttccc attgtaccac catttttttt cattccagaa cttacttgaa tgcgtcagat   1719720
aaccaacacc aagtaccacc aagatgctag cccaaataag agaatgattg gtaactggta   1719780
acaagtcata agcgtaattt gcaatgatga gcgccagtaa acctgtaaaa actgccgaag   1719840
tgagatgacg tctaaggatg gactcaatgg acttataagc aaaaaaaaca atacctagta   1719900
aaggccatat tttaccatcc aaagaaggaa ttccaaaatt cccttgcagc aagatccaag   1719960
ctgctaaaac caataaaaca ataccaaatg ctttcttttt catgtttttt acctcatgtt   1720020
tcttagattt tcttttagga gggattggta atgccgtgag acatgaacct ccttgtgcgt   1720080
ctgataaaag gaaatggtgc ccgttcctga aaaggacttg tccactgagt aaatctgacg   1720140
gatgtttgcg atcgttgact tggaaactcg attaaaatag cgaggcaaga tagactccaa   1720200
ctcatagagc ttgaggcgaa cctcataagc ttccttctgg ttatgagcgt agatcttgct   1720260
cccttctgtt tcaaagaaga gaatttctga caggtctaga taatattcac ctgtcccctt   1720320
gtaaaaagtc aacctcggag cctttgactc ttgcaagagg cgttgcaagt ctgcaatttc   1720380
atctgtcaaa gtgggggtct tgatgacaat ttcagtctcc tctaaattgc cgtcaatctc   1720440
aattcgtaac ttcatcacat ctcctttctg actctactat atcaaagcta agttaggaat   1720500
acaagggcaa aaaagcaagt ggtcaatttg aagcagtaag tggttgtagg actagcttaa   1720560
cttacatgtc agaataggaa gaaaaggaat ccccacacca aaccacaagc atagccaacc   1720620
aagacatcct tgggataatg aacaccccct aaaaccctca ccaaccccag caaagctgaa   1720680
aagatcaagc atactaagcc aataggtaga ctagcatgca gacaggccat ggagatgata   1720740
gttgccgaaa agacatggcg actgggcatc gaccgtcccg aactatcctt atcaagaagg   1720800
ggacagatat cccaagtttc ataaggtctc gggtgattga ttttcttacg aaacagggac   1720860
aaggccacaa aacctgatgc aggaataagc acataaaccc caacttgctg accaagtcct   1720920
agttgcaggt aagtggtgac tagcaagatc agatagacca ggggcatggc gactgtcatc   1720980
aaacgattga aactgcgtaa taggaataaa agaattggac aactagttag tctggagctg   1721040
atatttcgat accattcttg ataatttttc atttatgctt ctcatacttt tctagaactt   1721100
gttgagatgt tttccccttg gcaagccaat ccactagctt gtccaagcga cgtatttcct   1721160
gcatcagagg atcatcaatt tcctcaatac ggacaccgca aatcttccct gtaattgcaa   1721220
ttcgttcagg gacataatat ggtgcttgtc taaaaaaatc tccgtaagta acatccctat   1721280
ccagacaagc aagaacatca ctcacttcat accctgtcaa ccaactggtc acttggtgaa   1721340
ctgactctgc ctttccaccc tttcgctcaa cttttgcaat caaggctaag tagacagcag   1721400
caaatttcat attgtataat ttctgactca tacttctctc tttctatgtg tactagtata   1721460
aataagaaaa agaaggccgt caagccttct tttgatttat tcttctgctt catcttctgt   1721520
aaattgacta ttgtacaagt cagcgtagaa gccaccttgc gccatcagtt cctcatagtt   1721580
gccttgctcg atgatatttc catctttcat gaccaagatc aagtctgcat ttcggatggt   1721640
tgacaagcgg tgggcaatga caaaggatgt gcgtccttcc atcaaacggt ccatggcttt   1721700
ttggatcaat tcctctgtcc gtgtgtcaac agaagaagtc gcctcatcca aaatcaaaag   1721760
cggtgcatcc ttaagaaggg cacgagcaat agtcaatagt tgtttttgtc ttacagacaa   1721820
ggtcacggtg tcatccaaga tggtatcata gccatctggc aaggtcataa taaagtggtg   1721880
aattcccaca gccttactag cttccatcat tcgttcatca ctaatcccta tttgattata   1721940
gatgagattg tctcgaatag ttccttcaaa gagccaggta tcctgcaaga ccattgaaaa   1722000
ggcatcatgc acttctgaac gcgtcatagc cttggtatcc acaccatcaa tgcgaatact   1722060
tcccttatca atctcataga atttcatcaa aagattgaca atggttgtct taccagcccc   1722120
agtcggccca acaatggcaa ccttttgacc agcatgagct gtcgcagaga agtcatagtc   1722180
ttgaacattg acaccgtcca ccagaatttc tcctgctgac acgtcgtaga aacgtggaat   1722240
cagattgacc agagttgatt taccagaacc tgttgaccca ataaaggcca ctgtttgacc   1722300
agtttctgct ttaaagctaa catgttcaat aactgcctcc gaatttgccg catagcggaa   1722360
ggtcacatcc ttaaactcga cctgaccttt gaagttttca tcagtcagct gcacttgaac   1722420
agggttttgg atagaagaat gcaaatctaa aacttgatta atccgcttag cagagaccat   1722480
agttcgggga agaacgatga agagtgctcc catgagaagg aagcccatga caacctacat   1722540
ggcataagac atgaaaacaa tcatgtcact aaagagaggc agacgcgcta tcggagcagc   1722600
gtcgttaatc acataggccc caatccagta aatcgccaca ctcaaaccac ttgaaatccc   1722660
catcatgata ggattcaaaa tagccataag acggttgaca aacaaattca aacgggtcaa   1722720
ttcatcattt actgctgcaa atttttcatt ttgataatcc tctgcattgt aggcacgaac   1722780
gacacgaata cctgttaaac tctcacgagt gatactgttc agtttatctg tcagcccctg   1722840
aatcaaggac tgttttggaa aggctagcgt catcaaaacg gtcgtcatca ggacgttgat   1722900
aatcactgcc acaagtacgg cccagagcca gtattctgaa tgacctaaaa tcttcccaat   1722960
agcccagata gccataattg aaccacgcgt taccacttgc aagcccatag taatcaacat   1723020
ttgaacttga gtaatgtcat tggtagtacg cgtcaagagg ctaggaattg aaaatttctt   1723080
aatctctgtc tgcgagtaat ccaaaactcg gttaaaaata tcacttctca gcctactagt   1723140
ataagaagcc gccactcggg atgcaaaaaa tccaactgca actacggaca agaaggcaag   1723200
aaaggacatt cccatcatca tgcttgccga ctgccacaac tcatctaaat tagtttcttg   1723260
actacctagc aaatccgtaa ttttcgagat ataggtcggc acttccaact ctagatagac   1723320
cgaaaagcaa gtaaagagaa tggctagtaa aatcatcccc cattcttttc tactaattct   1723380
tttggctaat ttctttattc tctcctccta ttcccttgat attttgcctg tagttgaccg   1723440
agaaccttct caaaaatcag taattcatct tcatcaatgt cttccatcaa ctgcttgtct   1723500
atgcgttcaa aaaaagcctt aacctgttgc atctgagaac gtgctttgtc cgtcagacga   1723560
acaaacttag cccgcttatc aacaggactc gcctccaatt ccaccaaacc attttgcact   1723620
atacgcttaa ccagattact agcaacaggc ttggtaatat tgagttcctg ctcgatatct   1723680
ttaatcaaga ccaagtcttg gtttttctcg cgattatcca aaaaacgcac aacctgacct   1723740
tgcggcccac ccataaattc aatgccgcaa cgtttggctt ccttttgcac catcaggtga   1723800
atttgatgac caaaacgctt aaagactaac atcggtttat ccataatctc ccccttctaa   1723860
ataaaaatag ttctctggag aataattaaa tttctatgag aactattttc ttgattaaaa   1723920
aaatcccaag tgattttctc acttaggatc atgttctata ggttaaatta aaacccatct   1723980
acgttcgtat aaatcttttg gacgtcttcg tcgtcttcaa gaacgctgta aagtttttca   1724040
aaggtttcaa ggtcttcgcc tgacaattcc acttctgact gaggaatcat ttccaattca   1724100
gtcacttgga attcttcaat accagactca cggagggcaa cgatagcctt gtgaaggtca   1724160
gttggcgctg tgtaaactgt gattgtacct tcttgtgctt ctacgtcatc cacatccaca   1724220
tccgcttcga gcaattgctc aaagactgcg tccgcatctt cacctccaaa tacaataaca   1724280
cctttgttgt caaagaggta agaaacagaa cctgaagcgc ccatgtttcc gccgttttta   1724340
ccaaaggctg cacggacatt ggctgctgta cggttgacgt tagaagtcaa agtatccaca   1724400
attagcatag agccatttgg cccaaaacct tcgtaacgtc cttctgtaaa ggtttcgtct   1724460
gtgtttcctt tggctttatc aatcgcttta tcgataatgt gttttggcac ttgggcttgt   1724520
ttagcacggt cgataacgaa tttcaaagct gagtttgatt ctggatctgg atcacctttt   1724580
ttagctgcta catagatttc tacaccaaat tttgcatata ctttagagtt agctccatct   1724640
ttagccgttt tcttggctac gatattggcc catttacgtc ccattaggaa tctccttttt   1724700
tcacatttta atctttctta ttataacaca agtttttttg attttcacta gaggaaatgg   1724760
attttattag caaatcaagc taggatagca ctttacctgc taagatggtc ttgcctttct   1724820
atctttatca acaggcactc atccacattc aaaaaacaaa ctagaccatt atctgcaaat   1724880
agaaagtttc agccaagttt gacaaagtca gctcaaatta ctgtttgaag tttgtagata   1724940
taagcgacaa aaacaatcat actgcacctt ttgttgacag tctactccag acatatcata   1725000
gttcaagtaa atactttgaa attcaacagt tcttataggc gctattgtat tctaagaaat   1725060
caatagaaga gtttctaagc aaacctctaa tactcaataa aaatcaaaga gcaaactaga   1725120
aagctagcct caggttgctc aaaacactgt tttgaggttg cggatggggc tgacatggtt   1725180
tgaagagatt ttcgaagagt ataatttacg tgttcccaag atggagaagt tagactagta   1725240
cactggcact tctaaaacat tgctagcaat tgatttgttc atatttaatt tcattttttc   1725300
cataaatggg tattagatat aaacagcaaa atatttccga tacgtgtcgt tcttgaattt   1725360
ccaatcatct aaaacaagta aaggataatc aatcccctgt atatcaagga attggctacc   1725420
ctttttactt ttttacacat tctgtttgat agattcattt taacatcacg agcatactcc   1725480
aatggaaatc gctaggcaag agataaactt tcagatatcc gcagagagat catcgcctct   1725540
ttttgtcgca agcattctcc tctcctagtc attttctacc ttatcttcta cctgaggata   1725600
gagagttgtt ccccaaatag aaatcgtccg cttacgcact agtggcaaat cggttttttc   1725660
ataaaccgta cgccaccatt cccaggcaag cccggtacac tctctaattt tgacagagag   1725720
attacgaaca ttccctttta aaggaatact agtggtaaag tgagccgtta aatcctgccc   1725780
atttctgtcc caagccttag gagtcaagac ttccttacct tgatgatcat aggataattc   1725840
attccaagta atataatatt gggcaacata ggcaccacta tgatccagca gtaaatctcc   1725900
gtttctgtaa gctgtaacct tagtctcaac atagtctgta ctattttgaa aggtcgcaac   1725960
tacattgtca cgtaaaaaag aagttgtata ggaaatcggc aagcctggat gatctgctgt   1726020
aaagcgactg ccttcttgaa tcaagtcctc taccatatcc accttgcctg ttacaactcg   1726080
ggcacccgaa cttgggtcgc cccctaaaat aaccgccttc acttctgtat tgtccaaaat   1726140
ctgtttccac tctgtctgag gagctacctt gactcctttt atcaaagctt caaaagcagc   1726200
ctctacttca tcactcttac tcgtggtttc caacttgaga tagacttggc gcccataagc   1726260
aacactcgaa atatagacca aaggacgctc tgcagaaatt cctctctgtt ttaaatcctc   1726320
taccgttaca gtatcttgaa acacatctcc tggattttta acagcatcta cgctgactgt   1726380
ataataaatc tgcttaaaat taacaatctg aatctgcttt tcgcctgaat ggacagagtt   1726440
aaaatcaata tcaagagaat tccctgtctt ttcaaagtca gaaccaaact tgaccttgag   1726500
ttgttccatg ctgtgagccg tgattttttc atactgcatt ctagctggga cattattgac   1726560
ctgaccataa tcttgatgcc acttagccaa caaatcgttt accgctccgc gaacacttga   1726620
attgctgggg tcttccactt ggagaaagct atcgctactt gccaaaccag gcaaatcaat   1726680
actataagtc atcggagcac gatcgaccgc aagaagagtg ggattattct ctaacaaggt   1726740
ctcatccact acgagaagtg ctccaggata gaggcgactg tcgttggtag ctgttacaga   1726800
aatatcactt gtatttgtcg acaagctccg cttctttctt tcgataacaa caaactcatc   1726860
gggtagctga ttaccctctt tgatgaaacg attttcaata ctttctccct gatgggtcaa   1726920
gagtttcttt ttatcgtaat tcatagctag tataaagtca tttactgctt tatttgccat   1726980
cttctacctc ctaataagtt cctggattga gttgcataaa ctcagacttg ttcagcgaaa   1727040
tcagccgtgg ttggactaag taatccaaaa tttcctcgta caattcttct gagacattgc   1727100
gtcgccgtct ggctaaataa gaagtcggaa tgaccgtatt atccaacata aataccttat   1727160
ctaagtcaat caaggttggt cttgtaaaag gattacgagc tagatccggc tcttctatca   1727220
taaagttctt gaccaaacgt ctggtcaaga gagctggttt gaaggtctga tttttaacca   1727280
actctttgtt tttagtcatg ctgttgtcaa tacagatata catatgattc ttcacagcca   1727340
aatcgctact aatagtcgga aaaggcaaat aaagagctac aacatctcct ctcttaatca   1727400
agcaagagca cccccttttc tcctaatgta acatagacag gattgaccaa gtcttctgat   1727460
tgactcagaa tttccaaagt ttgagtttgg cgcgctgtca atttagtagc atcttgtctc   1727520
ttcaatacaa aatgcttgtc gccaataacc ttgacaatat aatccttctc caaagctgac   1727580
tggtaaatcc acatcagatg ttgtctgtcc tgagaactca agagagaagg attttcaagc   1727640
ctcccgatag tctgataaaa atcaaaaaca ggagctaact cctgccaatc tgattggcta   1727700
gttgtcaagg ctagaaaaag ggctttgcga gctgatactt cttggttagc cttgagagtt   1727760
actttcccct ccaagttttt tagaaatcgg gaaactccag aaagcaaatt tttctctaac   1727820
tgcgagaaat aaaaaccttt cgttcccaga cataagtctt tcatgtcgct ttctctagca   1727880
aataagagct caaacatttg atagtaaaag aaaaatatct ggcactgggt cgcgctcatc   1727940
ttttccttat cggcttcttt ttttaaccag agcaagggcg acaggtagct ggattgagac   1728000
atttcctcta cctcctactc ttttttaact ggagcatctg cactagctgc cacttctttt   1728060
gactggatac tttcccactg gttaatctcc tctgagataa gaccttcgca tgtcttgaca   1728120
aatagggcaa aagccttggt ctttcctgca tatttctccg tttggcattg atagaggaat   1728180
ttttctttct ccaggagttg cgcagttttt tggtaagaaa tccaattttc ctttgcatta   1728240
tacaaattga taatcccctc acacagcaag ccgagactgg ataaggcaac cgaaatcaaa   1728300
cggtagcgat cacctggcat aggaatagca caaaagacag ctatgaggaa acctgccacg   1728360
atttctgtta tttttaatac cttatagcgc ctacgatgtt gaacgctttt ctttaaaaaa   1728420
tgagctatct gtacgtctaa tcgctctgtc aggtacattt cttctggcgt catattcgta   1728480
actcctttca tttactttga taatcatagt ataacatatt tgaatatcaa agtatagtaa   1728540
aaactggact ataacttatt agacttcctg cgaaacaaaa tatggtatag tagttctatg   1728600
aattatgaag caagtaaaca actaactgat gcacgattta agcgtcttgt tggtgttcag   1728660
cgcacgactt ttgaagagat attagctgta ttaaaaacag cttatcaact taaacacgca   1728720
aaaggtggac gaaaacctaa attaaaccta gaagaccttc ttatggccac tcttcaatat   1728780
gtgcgagaat accgcactta tgaagaaatt gcggctgatt ttggtattca cgaaagcaac   1728840
ttaatccgtc ggagccaatg ggttgaagta actcttgttc aaagtggtgt tacgatttca   1728900
agaactcctc ttagttctga ggacacggta atgattgatg cgacggaagt aaaaatcaat   1728960
cgccctaaaa aaagaattag cgaatgattc tggtaaaaag aaatttcacg ctatgaaggc   1729020
tcaagcgatt gtcacaagtc aagggagaat tgtttctttg gatatcactg tgaactattg   1729080
tcatgatatg aagttgttca aaatgagttg cagaaatatc ggacaagctg gtaaaatctt   1729140
ggctgacagt ggttatcaag ggctcatgaa gatatgtcct caagcacaaa ctccacgtaa   1729200
atccagcaaa ctcaagccgc taacagctga agataaagcc tataaccatg cgctatctaa   1729260
ggagagaagc aaggttgaga acatctttgc caaagtagaa acgtttaaaa tgttttcaac   1729320
aacctatcga aatcatcgta aacgctttgg attacgaatg aatttgattg ctggtattat   1729380
caatcatgaa ctaggattct agttttgcag gaagtctatt atatatgcac agacatatga   1729440
aatctttttg agatagcagt tatgatatat ttatccattc acaacatctt ctgtaccaat   1729500
actacaatat tggtacattt tgattacaca atcgtttcaa aaaatatgat ggaagcctga   1729560
gtattttata gtaactccct tcctatcaac tagatcaacc agttgagtgt tgaatgttga   1729620
aacaccctag cctcagcaaa ggactatgag cagcatttcc tagctaatag gacgctccaa   1729680
atcacctatt ctaaatccat cactagcttg gtcagtaaga tacagactgc aaggcaagac   1729740
tgacgtggtt gatgagattt tggaagagta ttacaatcat agattcacca gtagacttga   1729800
ccgcagattt aactatagta gattgaaact agaatagtac acttctgctt ctaaaacatt   1729860
gttagaaatc gatttgactg tcctgatcaa tttgtcctgt tctcgtttca ttctactata   1729920
ctaaaaaacc acctgaaaca aatcaagtga ctagaggata aaaacgaaga ctgggcaaaa   1729980
agttttgaaa agcaaaaaac gcataatatc aggtcttgaa aaaccttgat actatacgtt   1730040
tgattgtggg aagattgact tcattttctc ctgaaattga agttttttct agtttccaga   1730100
tatagacgaa ttcaatatag ccatctcgct acaattattt taaccatcga gaaaattttt   1730160
cagaatttca aaaatttcat tttgatccaa tgaaatgtca ttattttgaa gaatagttga   1730220
cttcacaggc tctaattcta tcacaaagcg gtgcatgtct gcttttaccg cactacttga   1730280
tgttatagcc gataactttt catctcctag caaggaagct gtcaaacggg taaggtcatt   1730340
caaatgcttt ttaatggact tacttaaacc ttgagcacct gtggcagagc gctccctcat   1730400
atccagccaa gctttagcct taaaaataat taatactcaa tgaaaatcaa agagcaaact   1730460
aggaagctag ctgcaggctg ctcaaaacac tgttttgagg ttgtagatgg aagctgacgt   1730520
ggtttgaaga gattttcgaa gagtataaac cacaattact caataccgaa tacccctgaa   1730580
tggtttcttt ttcatgcacc aatatattat aataatcttc atccaataat aaggctgata   1730640
aactagcatc ttggtcaaaa tgtaagggaa tttctcgacc gtccttcttt aatggatatt   1730700
ctggtaagat actaaatagt tcaatcatag aaggaaactc aggattagtt gttgtaaatc   1730760
gaaaaagctg cgctttctca tctttctgac ttccttgata ctctcccaat tctaaaaaat   1730820
gattcaaggt agtataaaat tccttatttt ttacttcatc aatgatgacc atatcataat   1730880
cttttgttgt gcgactttta aatccttgcg aatccaatac gatagaggta gcagttcccc   1730940
caatcagaac ataatagttc tgaaaatccg caaacatttc ttgaaaaata actttcgtat   1731000
tagctggcat catcttctcc cagatactgt aatatcatat tttctagtgc ttcactctct   1731060
tcctctatac gtgggtcatc atcatctttt aaggtcaaat aaagagaaat cggatctaca   1731120
aattgtttat catgattatt tttaaaatca ttccaaaact cagatacaaa aggacgatat   1731180
ttccatatct ctagcatctt tcattttaaa acatgctgag aaagtggcaa ggataactga   1731240
ttgaattttc tctgccatat gacatagcta atattttcat ccgtttcagc taaaaaagtt   1731300
gaatgcgaca aagcataagc accaccatat agaaggttag aaacagattt tatctgcttt   1731360
atatcgccat ctggcaataa aatccgtttt ttgatgggat taaataaaca tgacacggat   1731420
tttaagaata attctttctt tgacaccgta tatgtgtaaa gcttattttg cttgtttaac   1731480
caatataaag ctttaaaagt cctcaaacac ctataaattg ttgagtttgg aagtccagtg   1731540
acttgtgaaa gcaaatcaac atctactact ttttgacctt ttgtcaataa aaaggcaatc   1731600
cacgttaatt gttcgctagg tgttaattcc ttagggactt cagtatcatt cgcattgagt   1731660
actagtccca atggagggaa gaagaggttt cccttaaagt ctacaaacgg aactctagct   1731720
tgaagtaatt gctttttttc actgtctgat aacttcgaaa acaccaaaac aacatccata   1731780
ttggcttttt cacccatagt gcgagcctga gtaacaaatg aactcaaact cccccttctc   1731840
ttttctttaa tcaataaaaa tgattcctta tgaaaagtca tttgagtata ctcaaacctt   1731900
tttacaaaac tgattggtaa agtcaaagtc agttcctcaa tactgacatc aacataaaag   1731960
gattgaaaaa ttgacattat ctttttgaca ttcatgtttt ttccttattc tatcattttt   1732020
attatatttt atcattcggt ataataaaat ataagttttt tgataaaata accaaaaact   1732080
actcgctatc ccctctcaca ttaccctaca tatcgtttga catgcgactg atagttcagg   1732140
aaaacttcaa ggagaacttt tctctcatcc actatgcagg acttactatt tcacttctac   1732200
tcctataggc tcaatttgac acttttcttt ttcgaattgc tcatatgcct cctgaatagt   1732260
gagttcgatt tatccaaatt tatttttgtc tattttgatg aatacttcca cgaagatagt   1732320
ctgaaaatga atttgcacca attttccttc tctttttaag catattattc cagatatgat   1732380
tgccctctta ttcagtaata aattacgctt taaacgcttc aatcagtata tctcctgttg   1732440
tcatatattc taaagaaaat tcttctacat atgatttaac atctcttagg ttattacttc   1732500
ctaatatccc attatgcttt ttcgctaagg aaatagatgc cccttctccc ttaccaataa   1732560
tcttgttact atcatgattt cttgttaaat ctctatataa tgcgtattct tcagttccaa   1732620
tgtctatgct cacaatctca gctgaaccct tagctaccaa ctgatctatc ctagatttta   1732680
aatggggaat tgtaggtata ttgatttcat catacacctc ttgtggaata acaattttac   1732740
ccaaatagag cttttctaaa agatgttcag tgccaaccca taaaaatact gaaatacaat   1732800
ctgcatcaat aaatacacga ctagtcaaac gacaactccc ccctcttcat ctagcccata   1732860
tacaatatca tatctgaaag catctagtaa cagttcctca tacttccctt gcgaaattct   1732920
gttattttct aaaagttgtt cagttgaatt aatatattat cctaatgcca tttctttttt   1732980
actttctgac aaaggacgat ataaacttgt atcatagcct aatcttgaag ctgtctctat   1733040
aacactaata tccatatttt taatttcttc tgcatcaagg tatccatcat tcctcaatct   1733100
atataacata gctttatgac tgataccata aaactgaccc aattttataa tatcttctac   1733160
ttcaagatga gttctattgg cattttctct gatttcctca accatcctat acagtgaaga   1733220
tgggaaaatt aaaaaataag aagcaaactg atccgctttt ctttcagttt catctccttc   1733280
accaatcaag ataagactga ctgaactctt cttcacctca tcataataaa gatgatacag   1733340
tccatgtgct aaagaaaatc tttaccttcc taatggcatg tctgaattga ctgcaatgag   1733400
actgaactga gttcctttat aacagactcc gctaatattc tttccgagtc cataaaatac   1733460
cagcgtcaaa ttttctatct tttgtaccaa tttaaaaata tctatcggcg attcaccatc   1733520
agctcccaac ttttttctaa gatttgaagc tttattactt aaatccattc gtgatattcc   1733580
tttcaccttt ttccattttg gcaatcatgc tttgattcaa agacaaatac tcagcaatct   1733640
tatcttgagt aagatttgaa gatattctaa gttcttttat tctttttcca acatcacata   1733700
catttatcac atacatttat catattcata cacctctcat aaaaagaata gcacactctt   1733760
gtcataattt tttaaataaa aaaattatga caaaacaagg aagcaattta ttgatgctgc   1733820
ttaaaaatct aaaattgatg agttcctatc aaaaatcgta tcttcaacct caaaacagta   1733880
cttaaagcta tccgactcgg tttacattgt caaatttaga ttttatttga gcataacttt   1733940
ctagtttgct ttttgatttt tgtttaatat agtagcaaaa ttgaaggaaa tatctccaca   1734000
agaaaacgca tactattaag ctttttcaag acctaataat atgcgctgtt ctgatttgaa   1734060
agacattcca ttattatttt actgtaatca agccatctgg ctctactgtg aattctggct   1734120
tgtctgccag tgttccgtct ggtttgaggt agtaccagcc tgttccgtcc gctgactgga   1734180
taaaggcatt tgataccatg gcgccttctt tagcgtctaa gtagtaccaa gtgtccttgt   1734240
acttgaccca gcctgtcttc atggcacctt cttcgttgaa atagtaccac ttatcagcga   1734300
ttttcttcca gcctgtagcc atttcgcctg agttgtcgaa ccagtaccag ttgccgtctg   1734360
tgtgcttcct ccagcggtct gcaagcatat agcctgaact gtcaaagtag taccaagtgc   1734420
cattgatttt ctcaaacttg tcttttggat aagagccgtc tgaatgtacg taccagtagc   1734480
cagtgtcatt cttctgccag cctgtttcaa tcgtcaagcc gttctcaata tcatgcttaa   1734540
actgctcacg gctaatgccc catttagcaa gatatggata agggtcaacg tggtctgagt   1734600
ggttgtttgg ttggttattc gtgcaatact cgtgcgtttt aattccagct aaactccctg   1734660
tatcaagcgt tttcggcaaa cctgcttcat ctgctagatt gcgtaagagt tcgatataaa   1734720
ggcggtagtc cgtcatgaac tcttctttgg ttgaatggct ttcaatcagt tcaaccgctg   1734780
cataggtctc agcattccaa ccgcccccaa cgtcccaggc accattatca acaggtccta   1734840
cctgcatgat gcaaccgttc ccaacaatgt gcgagaaaaa acctaattct gggtctttcc   1734900
gccagtgata atccgcttca ttctgtacgg ttgaatgcgg attcccagtt gagtgtgcgt   1734960
gtacttgcct atatggttgc acgccgactt gaggcaaatc tgttcttaat ttactcacat   1735020
taatttccat attctactcc ttatcaatta aaacaactca ttttttacaa tccagaacca   1735080
gaaactcctt tatttctacc ttacaaagaa gacaatctta gtcacgatta ggcttgtaga   1735140
tagaacttca aaacgcacta ttttgacact gtaaatagga ctgacaaggt ctgcattcta   1735200
tctacaataa caccccagac taaaaagatt ttcaaaagta tatttttaca gtctctatat   1735260
gtccttttca taaatactat actttattat atcatataaa agaagtcaaa agtctgttaa   1735320
actattttca acaccaaact aaagaagaga acacaagttt tttcgatttt cactagagga   1735380
aatggatttt attcagtaaa tccaactagg attgcacttt ggttgccaag attgccttgc   1735440
cttcttttat caagggatga cggaataatg agaagtacag ttgaactgtc atggcaaccc   1735500
agataagagg ttcacaaagg ataacaccct tatatcctgc ccaaggaata atcaaaacca   1735560
caaaaacgat ttttccgatt agttcaataa agctagaaac tagaggaagg atcttttgcc   1735620
ccaagccctg caagcaattg cgataaatca acaagaggct caaaatggga taaaaggttg   1735680
aactgatttg cagatagaga cttccatttt ctatcaagta accatctgtc gaactagcca   1735740
agaaggaaac caaagctgga ctggcaaaaa agaggaaaat acaaacaaaa actgcccagg   1735800
atatacttaa acgactgccg attcgaagac cttgaacaat acggtcaggt cgcttagctc   1735860
ctagattctg agaagcaaag gtcgtcattg atgcagaaat agcggtcata ggaagaaggg   1735920
caaaggtcat aatgcgtcga gctgccgtct gggcactaat aatcactgca ccaaatgtat   1735980
taacagaaaa ctgtaaaatc acactgccga tagatacaat tgaactcatc aagcccatag   1736040
ccaaaccttg ctccaagaga tccgcgtaca agcttttgtc ccatttgaaa tgtttaaact   1736100
gtggcaagag ttctggcaca cttttacgaa tataataaaa gcagagaacc gctgataaac   1736160
cttgcgaaat aatggtagca agtcctgcgg attgaactcc cagatgcaat tgcgtaataa   1736220
aatagagatc cagaaccaca ttaaccaagg cagagaaaat cagaaatccc agggctgcta   1736280
gactgtcacc aatagaccgc aacaagcctg caaaaagatt ataagcaaag ctgacaccta   1736340
cacaggtcac aatcatagaa atatattgat aagattgagg aagaatttct gcaggagtat   1736400
ctaagtattg caagagagga tacaagccaa gaaagcccag caacataact agaatgctca   1736460
aaagagcacc taaaatccag gtggctgcta ctgcttcctt gattttagtg aaattccgag   1736520
ccccataata acgagcaatg acaatcccca tgccattgcc aacaccaagt gtaaaaccta   1736580
caatcaggtc aaaaatcgct gtcgtcgctc ctactgcagc caaggattct tgaccaagaa   1736640
atcgtccaac aatcaagaca tcagcagtgt tatagagctg ttgaaaaata tttgatagca   1736700
aaattggaaa ggtgaagctt aagagcgagg gaagaatcgg accatgtatc aggtccactg   1736760
ttcgtttttt attcataaag ctattatatc agctttccag aggagcgaca agaaacagca   1736820
aactatatat agcggaatga aataaggaaa gtcaaatcga tttttaacaa tgttttagaa   1736880
gtagatatgt actattctag tttcgatcta ttatagttgg ttgagtttgg aatagtacgc   1736940
tgtagctgct aaaacatttc tagaaattaa tttgactttc ctaatagagt tgttcatatc   1737000
ttatttcaag ctactatata taatctaaaa acttgaatca aaaatcgaaa aagtagcgga   1737060
tttctccact gctttaacag cttattcttc aatttcgatt tcaagttcat cgcctaagtc   1737120
aagcggaact tcttcattca ctgcttcttc tttctttggc tcatcttttt tgttttcagt   1737180
atcttgttct gaaacttctt ctccatcaat caagccaaat ttagaacgga cttgcttatc   1737240
aatttcatca aagatttctg ggtgctctgc caagtatttc ttagcattct cagaaccttg   1737300
cccaattttt tcatctttgt aagaatacca agcccctgct tttttgataa tatccaaatc   1737360
gcttgcaatc ttcaaaagct caccagtctt agaaattcct tctccgtaca taatttcaac   1737420
tacggcttcc ttaaacggtg gagctacctt attttttaca accttaatct tagtttcttt   1737480
accgacattg gtttcttttt ggtcaccagt tcccttaatt tgtgtattac cacgaacatc   1737540
caagcggact gaagcataga atttcaaagc acgtccgccc ggtgttgttt ctggatttcc   1737600
aaacatcact ccaacttttt cacgcaattg gttgataaaa atggcaattg ttttggtttt   1737660
attgatagag gcgccaagtt tacgcatggc ctggctcatc atacgagcct gcaaaccaac   1737720
atggctatct ccgatatctc catcaatttc cgcacgagga acaagggcag caactgagtc   1737780
gactacgaca agatcaactg cacctgagtc aatcaatttt cccgcaatct caagaccttg   1737840
ctctcctgag tctggttgag acaagagcaa ttcgtcaata ttgacaccaa gggccgcagc   1737900
ataagctgga tcaagggcat gttccgcatc gataaaggca gcaatcccac cttctttttg   1737960
cgcttgtgca actgcatgaa gggcaaccgt tgtcttacca gatgactctg ggccatagat   1738020
ttcgatgata cgtcccttag gataaccacc tgagccaagg gcaatgtcaa gagctaaaga   1738080
acctgagctc atcacttgca ccttttgctc cgcacgttca cccaaacgca tgattgatcc   1738140
tttaccaaag tctttctcaa tcaatttaag agcgtcattc aaggcctttt cacgttctgc   1738200
cccaaatttt tttgaaattt cttctaattt ttttggtttt ttcgccattc tattctccta   1738260
cattctaatg atcctcagac ctatctacta ttatatcaaa agttagtcac ttaataaagc   1738320
cttgcgaact aggttaaagg catgcataac cgcaatgtga cgtacatctg ctcggcttct   1738380
gcctccaata ttaaccttga taacctcagt tccttgatct tgcgccaagc ctatgaagac   1738440
tgtcccaact gggtgtcctt ctaggctatc tggtcctgcc actccagtca aactaattcc   1738500
aaaatcagac tgggtcttgc ttcgtgcctg ctcagccatc ttctgagctg taaattcaga   1738560
caccacacca tgttcttcca aattcttggc aggaatatcc aacatccttg atttttcctc   1738620
caagctatag gtcacaaaac cacccttaaa tatacttgaa actccagaaa aattcgccac   1738680
ggtagcttgg aaaagacctg ccgtcaaact ctctgcagcc gcgatggttt tcccttgcct   1738740
tttcagttct tctaccacaa tgctggctaa actagtttct tccccataac catagcaaaa   1738800
gtctcgtaaa gaaattcctt cgaaagtctg gcagtccaag atttgatttt ccaagatatc   1738860
cagcgcttga ttcgcctctt cttgactgct agcctttgtt gacagacgta gagtgacttc   1738920
tcctgtcttg gcataagggg ccaaggtagg atcgatctga ttatcaatta aatcagccaa   1738980
aatcgtaacc aactggctct cgccaatccc aaagaaacga agaactcggg aatacagctt   1739040
gctccctgtc atcaacttgg gtagaagttg gtttaagacc atgggtttca attcacttgg   1739100
cggacctgga aggacgacat aggtcactcc gtctacttct aattttcctc caacagccag   1739160
tcctgtttcg tttggcagtg gaatcgctcc ttctacaatt tgagcttgtc tttcgttatt   1739220
cggtgttcgg gcatagtctg gtcgcagggt aaaaaagata tccaacttct cctgagcctg   1739280
aggatcaaag actaatgctt tccctaaaaa tttagctagg gtttgtttgg ttaggtcgtc   1739340
ctcagttggc cccaaaccgc ctgtcaaaat caccagactg ctacgttgac tggcaatctc   1739400
aagcaaagac aagagacgaa cttcattgtc tcctacagcc gtctgaaaat atacatctac   1739460
cccaatctca gctagttttt ccgacaaaaa ctgggcattg gtgttgacaa tctgccctgt   1739520
caaaatctct gttccaacag caatgatttc tgctttcatg tttcctccta cctatctatt   1739580
cgtatttttt tgaaaaaatc gcaggaattt tcctacgatt gattttttta tttgtatcaa   1739640
aagttaatta tcttcatcac caacaggtgc tctgccaaat aaatcttcaa ataaaaccgc   1739700
attggtttca agctgagtaa cttcttcttg tcccaaagaa cgtcggagta gattttgcat   1739760
ttccaacata tgtgctctcg aaacaatctg gtaagaaaca ccttgaagta tctctccttc   1739820
accctgcaac tgctgagttt caatggtttt aaatgaatct ttatagccta gcaagttagg   1739880
gatacttttt gcagacaaat caatattggt ctgcatattg tcactcaaag cttttagaat   1739940
ctcttgataa tgaccaatgc tatttaaact gagagctttt tccatgactt tttgaataac   1740000
ttcacgttga cgtttttgac gaccataatc cccctcagga tcttggtaac gcattcgtgc   1740060
atagactagg gcttcttctc ccccaatatg ttgctcccca acaccgatag aaatagtatt   1740120
aaattcttct tggtcactga tagaaattgg gaaacctagg atattattga ctgtaatacc   1740180
tcctactgca tccactagtt tttgcaatcc tctcatattg accatcacat agcgatcaat   1740240
atggatattc atcatttttt gaatggtttc tatagcaagc tctgctccac catctgcata   1740300
tgctgagttc agtttcgctt catgagcctg accattccct gattcaatgc gcgtcagaat   1740360
atcccgctct aaactcatca ttgttgtttt tttcgtttta ggattcactg tcatcaagat   1740420
catgctatca cttctaccga cccaagtttc agttcgttca acatttccgg tgtccactcc   1740480
cattaacaga atggttagag gttcagtcgc ttcaataacc ttggtttctt caccgatttt   1740540
tttataggtt ttagctaagg tttctgtccc ttgttgataa atagtataag caaaaacacc   1740600
tactcctact acagttacag aaagtaaagc tagcaccatt ccaataattt ttttaaccat   1740660
atttctacta acctatcagt ttacccatca agtaaacatc gataaatttc ccttcttcta   1740720
tatatgcccc acgctcttgg ctaccttcaa tgacaaagcc atgcttttga taaagatgga   1740780
ctgctgcttg attacgagtt tggacagtca gttggagacg acgcagaatg ccacttgctt   1740840
gtgcccactc tatcgcttct tctagcaaca aacttcccaa gccattattc caatatcttt   1740900
ttccaatcac aatgaagaga tctccaatat gacggactct cttacgctga tcagctgtaa   1740960
tatttacaat accagcaatt ttgccattta agaatgcaag taaggttatc tgattgtccg   1741020
aactagcttg cttgttgagg aatatttcca tctcctcact agtcaagaga ataccatctc   1741080
cgtctaggct ggtaaagtct gtctccaaac tcacacgatt taaaaaggcc actaattcag   1741140
ctgcatcttt gggctctgct tccctaatga gcaattcata ctccatattg aagctcctct   1741200
aacaatttct cagcacgcaa accctttgcc tgaaaattta aacggcgtcc atctgcttct   1741260
tttagaattt ccaattctaa ataagcatct ggcaaggcat ctcctaagag atttccccac   1741320
tcaataacag tcacgccgcc accaaagata aactcatcca agtcgataga atcagcatct   1741380
ccttcaatac gataaacatc taggtgataa agtggaagtc gaccttcata ctctctcacg   1741440
atagtatagg tgggactttt aatcatttga gaaatctgta atccttttgc aagtccttta   1741500
gtaaaggtcg ttttacctgc acccagttct ccagttaaga ttaaaacatc attctttgct   1741560
aatagatggc ccaaacgctc ccctaaggct tgcaactctt cttcattttt tgtgtacata   1741620
ctcttattat accaaaaact tttcttttgt gtctattttc ctactaaact tatcatcata   1741680
acatccataa aaaacaggct ttctctaaaa gaaaatgagc gtaacaatga ccaatacaag   1741740
atctcggaaa atatgaccat aaaaggaaac ttccttctta accgaatttg ggacaagata   1741800
ggctgcaaaa aacaagccca gtccaatata aatcagaagt gagacaatgg tcattggatt   1741860
tcttaagaaa agaagtgttg ctaaaatagt caccaacact gtcttttttc tgtccagcat   1741920
agcaagaaaa tcgcgcacgt attttttcaa gggtaaaaaa atcagcaaat ctagcccaaa   1741980
taggaaaaag aaggatggca ataaaaagtc aactaattct tgctgcagcg tatttttgat   1742040
gaacaagtta tctgacaaaa caagaacagc tcctaacaaa ttaattaaga gtaacatact   1742100
gtaaaaaagc ttcaccgact tcttactggc taggacacta tggacttctt gcttacgggt   1742160
ataaagataa tttactccag cacagattcc tgaaacgaaa accatgcttc cgatgaaaaa   1742220
agctgtactt tgtttaaagg acaagatgca ttccttccat aggaaacagc tactcaaact   1742280
gatttgaatt aaagctaaca aaaataagat tctcattgat ttcatcttct ctctcccttc   1742340
ctaccaatca ttatactagg agaaaagaga gaactgtttc taatcttctc aaatgtctct   1742400
ttaagacgct aaacaaacac tagagactaa tactcaatga aaatcaaaga tcaaactagg   1742460
tagctagcca caggttgctc aaaacagtgt tttgagattg cagatagagc tgacgtgatt   1742520
tgaagagatt ttcgaagaat ataaatttga aatcatgaaa atccgtcaaa cgggtggttg   1742580
ttttgtctcg cacctcacgg agcgagacgg actcagagtc acataattat aaggctgata   1742640
gtattaatct aactatcagc cttacaggtt atttaacgtt tcagaaaaac tataatgtca   1742700
agattaacta aacagtatct agttccttca aataattttc tatcttcatc aacattaaag   1742760
gattgttata aatcttacat aactctcttg cttctatata ataatttttg acttgttctc   1742820
tgtctagaaa tttggctcca gcatttccta caagaataag tagaggagcc aattggtagc   1742880
ttgtctgtct ttgtttacag agttcaatcg tttcaagagc ttcttggatg gcttcattat   1742940
atttttcctt tgatactagg tagtgagcgt agttgtaacg aactctgatg tagccaaata   1743000
aaaactcttg atggtccaaa ttttttgtct gatacaactc tattaaatga gagtagtttg   1743060
cctcatattc ttgttcacga cccactaagg aatagaaatt agatagagta ttcaacgcct   1743120
ttaaataaat cagagtattt gaagagactt ttaataatat attttccaat gacgaaattg   1743180
cctcacactt actgtcatat tgatagaagt caattataga tttaatccat tcaaggtaag   1743240
ttcggtcttc taatgttaga aaagtgcttc gttctacttc tattttataa agatattcta   1743300
aatcgtcata atttctgtca tctaataggc gagcagatag atgtttgaaa ttagagaggt   1743360
tagacttaac ttcgatttgt tcattgaaaa agtaatccaa agggacttca agtcgttgag   1743420
agagtttgaa taacaagtct gcggagggaa taaaatgacc tctttcaatt ttactaatct   1743480
ggctttgttc acaaattcct tctgcaagag tttgttggga gagtctcaac tcttttcttt   1743540
tcaatctgaa tttctctgcg agtgtattca ttaaagataa taaaccttcc tatttgctta   1743600
atttcattat aaagttttta gttcaaaata gcaagttaaa ggaataaata attctttatg   1743660
gtaataaaca aaaaaaaaag ttaaaaatta cataaaaata cttgactaaa taaaatatat   1743720
ctgttagaat aaaaacaagg aaaaagaaag gggtttcatt gcatgagaaa aaaacgtgga   1743780
attaaaaaat tagttacatt tgcattgcta ggtgttttta tgtttagtaa tacaattcct   1743840
taccaacagt ttattcagaa gaataaacaa ttggagattc gagtgcaatc gcaaaagaag   1743900
tccaatggtc ttgatgttgg gaaggcggat taaaacccga tattttgcac gagaatgaga   1743960
gaattataat ttatctgaaa aaacgaaaaa tatagagcaa cttatttaac tttttataag   1744020
gaggagttat tacttatgac caactttaat tcaaacgaaa aattttgtgg aaaaagttta   1744080
aaatcattgt ctgctgatga aatgagttta atttatggtg catctgatgg tgcagagcca   1744140
cgttggacgc ctactcctat tattttgaaa tcagctgcag ctagctcgaa agtatgcatt   1744200
agtgcagctg tttctggtat tggggggcta gttagctaca ataatgattg tttggggtaa   1744260
attaaaatga aaaatgattt tgtaatcgga aagagtttga aagaattatc tcttgaagaa   1744320
atgcaattgg tttatggtgg cacagatggt gctgacccta gatcaacaat tatatgttct   1744380
gctacattaa gttttattgc atcatatttg gggtcagctc agactcgttg tggcaaagac   1744440
aacaagaaaa aataaaatat tcaattttaa aaataaaagt tgctctttat tttcctctct   1744500
cgtaactaat aattttgaga gaggtttttt tttaaaacaa tagtaagtcg tataggtttg   1744560
aggtaagtaa atgaaatata aaattaaaaa tgtgcataaa acattgttta ttaaggaaag   1744620
atatcaaata ttatctgaac gaaatgataa ttccttaaat aacttttcat taaataattg   1744680
gcgttctaca atgtcaatta tttctgaaaa aacttttgaa gaaatgttga aattaaataa   1744740
ttacaataaa aaaatatttt ctaacactgt gaactatgat tataccgagg aacagataag   1744800
actatattca gaatatgcca aaaattcgga atggtataaa tttgcggagg gttcatttga   1744860
aatatttaga aaacatcccc aaagaattaa ttttaagaaa gatttttcta gaattttgga   1744920
accctttatt attaatttgc ttaaattaat caataattat ctagagaata aagaatacga   1744980
gtggattgac aagaatggaa atattttttc ctctctagta ttttatttag aagatttaat   1745040
ctatccttgg attgttaaac ctttggtttt agagataaat tcattgcgtg aaaaaggttt   1745100
acttgaaggg gaatcggagc agcaacggta caaatatttt ataacattgt ttgacaagga   1745160
agagaatata ttaaattttt ataacaaata tcccgtttta ctgaggcaaa tatcggagtc   1745220
ttgtcttcgg ttctatactt attttataga aattttatca aatttagaaa atgattttag   1745280
tgtgctagaa gaagaattag ggctaagggg gaaattaaat gatataaaat ttggaaaggg   1745340
tgatacacac agccaaggaa aaactgtttt gatactcttc tttgatgacg cgaaaattgt   1745400
ttacaagcct aaaaatttaa taatcaataa ctcactaaat actattgctg agtatatccg   1745460
aaaggttgat gaaaaaatta ggataagaat acctcgaact attgcttatt cggatcacag   1745520
ctatgaagaa tttattgatt atctacctct agagcaaaag aaaaatttac ctgaatatta   1745580
ttataatttt ggtgtgcttt tagcatttat atatttattt aatgggagtg atatacattt   1745640
tgaaaattta atttcctatg gagatatgcc tgtaataata gactttgaaa caatgttaca   1745700
gcaacctcta tttgatgata aaactggtca gagtttgctg gataccctgt ttcacagggt   1745760
gactcgaact ttgcttcttc caacagaggg agtaaaaagg gaggatggtc ttgatgttga   1745820
gatgagtgct cttacaggaa attttaagaa ggatgctttt aatggtcaag ttttaattaa   1745880
tttaaatact gataaggtaa agtttgatat tgggaaaatt gattttgaag gtgggaaaaa   1745940
cctgcctgtt cgggatggtg atatagaatt tgataagtat ataaaagatt tcaaaaaagg   1746000
ttttagggat ttttatctga tatttgaaga gttaaataaa acagaagaat ttaaaatgct   1746060
attaaaagca aacttgtatg gtttaaagac aagggtactt tttagagaca caaatagcta   1746120
tgcttcagta ctatcttttt tatatcatcc tgatttttat gaagaaatgt tagatagaga   1746180
aaaagcattg gaaaatctct ggagcaataa gttttctaat caaggtattg tagcaagcga   1746240
atgtgaacaa atgaggttat tagatattcc gattttttat acagatacaa atatcaatga   1746300
aatctacgat gattttggaa atcattttat ttccctacat caattttctg gatatgacta   1746360
ttttatgaaa tatttaccta ataataattt ggaaaattta gaaaagcaac ttgatatcat   1746420
tgaaatttat tttccaagct ttgatcagcg aaaaaaagga tataaattaa acttatctaa   1746480
tagaaaaaaa ctcccaaatg aaagtttagt tactattctg cataatgaag tagaaaatat   1746540
tgcagactct ttggttatta ataatattta tgacgaatat ccaatttgga gtatacctgt   1746600
taattttaaa ggttctaaat ggtgtcttga acaaacgggt aatgatatgt ataggggtag   1746660
agctggaata ttactgttta tgtactatgt aaaattattg aaagataaat catcatatac   1746720
tcaactgtac aataaaatgt tatctgcaat tccgccatct gtttctttat ctaagaccac   1746780
atttggttta actggggata taggatattt cattgttcta tccattatag aggattacga   1746840
tacaaatact ctcgcatgct taaattatat aaagagtgtt ttaactgagc ttgaaaagac   1746900
tgattttgca agtgtttcaa acaagtctga ctatattaat ggtcttctac ctttaattaa   1746960
tacactggta agatattata ggagaggaat agagaaggaa cgtgttctaa ggctagtatt   1747020
aagtttaggt gatacgctat ataatgatgt aagcgagaga gataatagta attttggata   1747080
tagttttggc catggactat caggtgtaat ttttacatta aaaaatattt ataaagtgac   1747140
aagacttaaa aaatataaag aattaatttt acaactagtt cctagggaga aaatcaaaat   1747200
tcattctttg aagtggtgta gtggagaatt tgggacatta gttaatcatc cccaaagtgt   1747260
tccagaggga attgtagcta gtttagataa tgatacattt tgccatggaa gtatggccat   1747320
aataaatttt tacatcgact acatgaaaga aatggatact agtatggaat tggagtcttt   1747380
attgtgtagt gttgtaatga ataaatcaaa agaaggagag tatcgtatcg tccaaacaag   1747440
caatttccca gatttttctt tgtatacagg tgtgactggt attgcttata cttttttaag   1747500
gtatatcgca ctgaatcaga atgacaaaaa gatagttatc ccctcattac ttgaaatcta   1747560
gcttaattta tagttttgtt tctaaaatag aggtgtccac tcattaagca atataaaaat   1747620
accaagattg actagtttaa tatgtaattc tataaaatat ttttaatagt gtagcttttc   1747680
gttgagataa taatataata aagaaaagtt ctattctaat tgctaaacgg cttgaggtat   1747740
atgctactgt tatagaaatg attttaaact aaaatcaaaa ttactccaaa aatagtattg   1747800
attttggttt aatacaaaac atatgtaata atgtgagtca acaaaagtct gtttttgtac   1747860
catactatct tgaaaaatct actaaattca aattgagagg atgaattaaa atgaataaaa   1747920
tatttatata tgcaggagtg cgaaatcata actctaagac tttagagtat actaagagac   1747980
tttcaagtat catttctagt agaaataatg ttgatatatc tttcaggaca cctttcaatt   1748040
cagagctaga aatatctaat tctgattcag aagagttgtt taagaaagga attgataggc   1748100
aaagtaatgc tgatgatgga ggtgttataa aaaaagagtt attagagtct gatattataa   1748160
ttatctcttc tcctgtatat ttacaaaacg tatctgtgga cacaaaaaac tttattgaaa   1748220
ggattggggg gtggagccat ctttttcgat tagctggaaa gtttgttgta acattagatg   1748280
ttgctgagag taacggctct gataatgtgt cagaatatct tagagatata ttttcatata   1748340
tgggaggaca gatattacac caagtttcaa ttaccaattc actcaaagat attgcagagg   1748400
ctcagttgat ggaggcaact tataaaattg aagatgtact tgaagggaaa attaagtaca   1748460
aaacaacgga ttatcaagaa agagcttacc agacattaaa attaatttta gaaaattatg   1748520
attccgaaca ttttgagaag atgtattggg agaaaaaacg cctttttgaa gctaatagtt   1748580
tagaggaatg gtattatgtt gaaaatatta aataactctg tcatatattt atgtttgatt   1748640
ccgttattgt tcctattatt gataattttt ccaaatgatt cattaatcta ttattttcga   1748700
ttgattttaa tttcgttaat atcaattaca ttacatgaac taggtcattt tttagtggga   1748760
agatgtttat cttataaact agagatgctt gctactccct ttttcttcta tttcagaaaa   1748820
aaaatatatt tcaaatttcc agtgttatta gcattcggtt attgtcaaat gagtaataga   1748880
aacattacta atgaaaaaaa tagtgatagg aatttggtgt tctacttctt tgggggaggt   1748940
ggagctaacc taattgtcgc aatattagca cttttgggat ttgtgccgta cgcatcagaa   1749000
ttttttattt tgaatataat tctttttcta gttacggtat gtttaccaat tgatggaaca   1749060
gatggcaatg ctattagaga gatagttttg tattcaaaag attcaaaaac atatcagaga   1749120
ttctttgcga acagtctcta taataatcct tatataacaa tcgacgattt tgcaaaatta   1749180
acctctaaag aaaaatcttt tttttcaaaa tttgaaaaat gtttgataaa cctttacttt   1749240
gaagtgaaag gtgaagggtc agcatttaca attgctaatc atgaagtttt tgattcaaat   1749300
attcaggaaa atattatcca tgagtactat aaattactac ataaatcttc tgattggatt   1749360
attccacaga acttatcttt agaagaagtt gtttttacct tgtcaaacta tatttactcg   1749420
aaaaataata aatatttaga aaagattaag tatctaaaga aattagtaga ttttagacaa   1749480
gaagaaatta tcgactttat tttgaacaag gaggaagtat tgtgaaaatt ccaatgatat   1749540
atcaaatgga aaattcagaa tgtggattag catgctgtgc catgatattg aactatttta   1749600
aatatgagat ttctttaaat gaactacgtg aaatctaccc atcatccaga tctggatatt   1749660
ctctcctatc tataagtaaa gttttaggag attttaatat aagttctcat gcttttaaag   1749720
cttcggtaag agatttaaaa ccgctcagtt tcccactcat ttgcttctgg gagagttctc   1749780
attttattat tcttgaaaaa attagtaaaa acaagtttta tattttagat cctgcaaaag   1749840
gcaggcagag aatgtcaata agtgaatttg aaaggcatta ttcaaatatc attttaacat   1749900
ttaaaaagtt agatagcttt atgtctcgta aagataataa gaagtcgcct gttttaaagt   1749960
atttttttaa gtataggaat aagctaggga ttttattttt tgtaacagca ttattgtatg   1750020
taatacaatc attagtacct atagctaata gatacataat tgacacgaat ttcaaggacg   1750080
attcgtattc gtctagaatg ttatttacta tattatttat atttactgtt tcattctcac   1750140
taatgtattt attaagacag atatatgttg catccttaaa atatataatg gataaagaga   1750200
ttagctatga ttttatgaaa catttgatat atttacctta cagtttttat gaaaaacgta   1750260
ctttagggga tatacttttt agagctaact ctattgttta tataagagaa atactatcaa   1750320
ataattttat agcagctata cttgatttgt taatgattgt ggtttatgct gtggttttat   1750380
ttagcttttc taagtacatg gtaatctttt taatatcact aagtctagct ctatctattg   1750440
taatgtatcc aatcataaaa atctcaaaaa atttaattga taaaaatata aaagaaaagg   1750500
ttaatgttca aaatattact tccgaagtaa tttctaaaaa tagtgatatt aagctaactg   1750560
gagaagagga attttggatt aacaaatggg ataattttaa tacaaaacag ctcatcatag   1750620
gtcgaaaact tgatatacat ttatcaattg ttagtagtat aacgaatgtt ttacaaatta   1750680
ttctccctgt tttgaccctt attgtaggtg taaatataaa aacattcgaa caattgacgt   1750740
taggacaaat tgtagcaata agtacagtct caccatactt tatttctcct ataatttctt   1750800
taagtgataa ctatatacaa ttaatgttat taaagggata ttttttaaga atagaggatg   1750860
tgtttaatac taaatccgaa ttaattccag aaagagtcag tcaagatata aaatttgata   1750920
aaaaaataga attaaaagat atttggtata aatatggatt atttgatgat tatgttttga   1750980
aaggaataaa tgttactatt aaaaaaggag aaactgttgc tattgttgga gaatcaggtt   1751040
caggtaagag tacattagct aaaattttat taggtttatt agaacctaat attggttcaa   1751100
tagaagttga tggagtagaa aaagaagaaa ttggtcaaac attgtataga aagatttttg   1751160
gagcagtgtt acaaaattca accctaagtt atggtacctt aagagagaat ttgacatttg   1751220
gacactttgt ttcagatgaa gaattaatga caaatctaaa ttcaattggt cttagcaatg   1751280
tagttaaatc tttacctctt ggattagaga caatcatcgc tgaagaaggt aataactttt   1751340
ctggagggca gcagcaaatg atacttttag ctcgttgtct tttgtcgaaa ccttcggtag   1751400
ttgttttgga cgaagcaaca agtagtttag ataatttatc tcaacaaatt acaacttctt   1751460
acttaagtga aatcggtacc actaagattt taattgccca tcgactagat actatcaagt   1751520
ctgcagataa gatcttagta atgcataatg gtgaaattgt agagattggg acccatagag   1751580
aacttcttga actaggaggc atttataagc aattgtattc aaataattag tttttgatta   1751640
aaagggtaaa tttatgaaga ttatgaaaaa aaaatattgg actttagcga tattattctt   1751700
ttgtttgttc aataattctg ttactgctca agaaatacct aaaaatcttg atggcaatat   1751760
aactcacact cagactagcg aaagtttttc tgaatctgat gaaaaacagg ttgactattc   1751820
taataaaaat caagaagaag tagaccaaaa taaatttcgt attcaaatcg ataagacaga   1751880
attatttgta acaacagata aacatttaga aaaaaactgt tgtaaattgg aacttgaacc   1751940
acaaataaat aacgatattg ttaactctga aagtaataat ttactaggcg aagataattt   1752000
agataataaa attaaggaaa atgtttctca tctagataat agaggaggaa atatagagca   1752060
tgacaaagat aacttagaat cgtcgattgt aagaaaatat gaatgggata tagataaagt   1752120
tactggtgga ggcgaaagtt ataaattata ttctaaaagt aattctaaag tttcaattgc   1752180
tattttagat tcaggagtcg atttacaaaa tactggatta ctgaaaaatc tttcaaatca   1752240
ctcaaaaaac tatgtcccca ataaaggata tttaggaaaa gaggagggag aggaaggaat   1752300
aatatcagat attcaagata gattaggtca tggtacggct gttgtagctc aaattgtagg   1752360
ggatgacaat attaatggag taaatcctca cgttaatatt aacgtctata gaatatttgg   1752420
taagtcgtca gctagtccag attggattgt aaaagcaatt tttgatgctg tagatgatgg   1752480
caatgatatt atcaatctta gtactggaca atatttaatg attgatggag aatatgagga   1752540
cggaacaaat gattttgaaa catttttgaa gtataaaaag gctattgatt acgcgaatca   1752600
aaaaggagta attatagtag ctgcattagg gaatgactcc ctaaatgtat caaatcagtc   1752660
agatttattg aaacttatta gttcacgcaa aaaagtaaga aaaccaggat tagtagttga   1752720
tgttccaagt tatttctcat ctacaatttc ggtcggaggc atagatcgct taggtaattt   1752780
atcagatttt agcaataaag gggattctga tgcaatatat gcgcctgcag gctcaacatt   1752840
atctctttca gaattaggac ttaataactt tattaatgca gaaaaatata aagaagattg   1752900
gattttttcg gcaacactag gaggatatac gtatctttat ggaaactcat ttgctgctcc   1752960
taaagtttct ggtgcgattg caatgattat tgataaatac aaattaaaag atcagcccta   1753020
taattatatg tttgtaaaaa aattctggaa gaaacattac cagtaaaaaa tggtataaaa   1753080
gtgttaaata taccaaacgt attgagatat gatttgaata tgttacaatt agaatataaa   1753140
aatgaacaaa gttgggatag tttcatagat aatgttaatt taattgagtt ggaagagaga   1753200
attcaaacta ctattggaat taaacaaata aacacacaca atattattac tattgcccga   1753260
gaagggtact ctcaaaatta tttacctaac acttcagaaa atacatataa ttcattacaa   1753320
gtcagtttag ttggagtatt actacttttt ataagtatgg taaatatttt atgggctaaa   1753380
aaaagtaaat gaaaataaaa tttggagccc tctgaaaaag taagtcctac agttcaacta   1753440
aaatgagtca aaagatgaat caccttgatg taggggagtt tgtcttattg ctgcctgaac   1753500
acctccgttc agaggaagaa cattataaat ctgtttttga agacgactta accagtcgca   1753560
tatctagtca agatgaacga cagcaaatga ctgctacggt aggttattta gaatcaggtc   1753620
aggatcgttt tgtgtataat acgaccccta tttcttacca gcagtttttg aaagatccaa   1753680
tcatcattgt tataacaccc caatcaactg gtccacagtc cattttgttt tggatagacg   1753740
cagtacagaa ctacgttctc tttaatcaat tgtctgatgc ccaggagctt atccagagac   1753800
aaggcattga aaattgggtc tcagaaatgc aaacaggtta ccacaactac atcacattat   1753860
tggataatat ccagagggaa cgttgggtaa tgctagcagg agctgtgctt gggattgcaa   1753920
cttcaatctt gttgtttaac actatgaata ggctctactt tgaagaattt agacgtgcca   1753980
tttttatcaa acgcattgca ggtctcaggt tcttagaaat ccatcgcact tatctctttg   1754040
ctcaactggg tgtgttttta ctgggatttg ttgcgagtgt atttcttcag gtagagatag   1754100
gagttgcttt cttagtcttg ttactcttta ctggtctatc tcttttacag ttacatgtcc   1754160
aaatgcagaa agaaaacaag atgtccatgc ttgttttgaa gggaggttaa tatgattgaa   1754220
cttaaacagg tgagtaaatc ttttggagaa cgagagttat tttcgaatct ttcaatgaca   1754280
tttgaggctg gaaaagtcta tgccttaatt ggttcaagtg gtagcggaaa aacaaccttg   1754340
atgaacatga ttgggaaatt agaaccttat gatgggacga ttttttaccg aggtaaagac   1754400
ttggccaatt ataaatcaag tgattttttc cgtcacgaat tgggctacct cttccagaac   1754460
tttggcttaa ttgaaaacca aagtattgaa gaaaacctta agctaggtct cattggtcaa   1754520
aagttgagtc ggtcggaaca gcggttgagg cagaagcagg ctttagaaca ggtcggcctg   1754580
gtttatcttg acctagataa gcgcatcttt gagttatcgg gcggagaatc gcaacgggtt   1754640
gccttggcaa aaattatctt aaagaatcca ccctttattc tggcagatga gccaacagct   1754700
tcaatagacc cagcaacctc tcagttgatt atggagattt tgctatctct tcgagatgat   1754760
aataggctaa tcattatcgc aacacataat ccggcaattt gggagatggc tgatgaagtg   1754820
ttcacgatgg atcatctgaa ataaaaatcc ttgtttttaa ttgcacgatg agttactgaa   1754880
atattatcat gaatcaagaa ttggagttaa tttagaattg tacttaattt agaattgtac   1754940
tttattaata ttgaggtaac tttttcttga taaaggaaga aataatggag aggaagttag   1755000
aatgaaaaaa ttcgacaatt atattattga gaagccttgc gattctaatt cagataaact   1755060
gcaaaaaatc ttaataattg aaagtttggt agatgatatt ttgcaatttt ctctcagaat   1755120
caataatagt gtaggagaga ttttcctcct acaaccgttt taaaagaaaa ctatctttat   1755180
tccatgttat tttgaggaag atattgtgaa agtcaaagat gatgataaag ttgagtggaa   1755240
tttgttagaa tttcaaaaat ttagagcatt tttggcttag taatctgtgt tgaaggctca   1755300
aaacctatgg taaaaaagta gctttgaaaa cgtattgcct ccaaagattt agttaaataa   1755360
tgatttaaca caaaaagaaa ttattgaagt tctggaaaga tgttgtttca gtattgagaa   1755420
aaggtgggaa aaacttgcga ttttcacaga gaaaggaaga aaaagtatag aaatatagtc   1755480
aattgaaaca agaacaggat aaaagaacct tttgtgccat atttttctcc tttcgcttta   1755540
caattggatt gaacaccttt attgtatcgc gtttggagtt tttttggtat aaccttcgac   1755600
gcacacccgc atagcgggtg ttttttttgt ctcgcaccta acggagcgag acaaactaat   1755660
agtcacttaa tcaaaaaacg caccatatca aaaactaaaa agtttgatat catgcgtcat   1755720
gtcttaaact aattgactat actttctatt caaatgagct tttaaccaat tgattgagcc   1755780
aatccactct taaaaccaaa gagcaatttc tcgcttagct gactcttctg aatctgaacc   1755840
atgtacaaca ttttggataa tctcattttc tccagcagct tttgcaaaat cacctcgaat   1755900
agtgcctggt aaagcttctt ctggacgagt tgcacccatc atggtccgcc aagtttcgat   1755960
tactttggga ccagaaatga cacccacaag aactggacct gaagtcatga attcacgaat   1756020
cggtgggtaa aaactctgac caaccaagtc ctgatagtgc tggtcaatca actcttctga   1756080
aacctgtgaa cgaaactcca atttttcgat tgtaaatcca cgttgttcga tgcgctttaa   1756140
cacttcaccc actagccctc tttttacacc atctggtttg atgataaaga atgtttgttc   1756200
catacccgtc tcctttgtca gcttctttct tttattttac cacatttcgt ggaaaaatgg   1756260
agaaagtttt cagaagagag aatgagagaa ccctcgggtt ctctcattct ctcttattct   1756320
actgtttctt ccacagtttc aacggcagta tccacaacta cttctgttgt ttcttcattt   1756380
ccttcttcct ctactggagg attaaggtat tcttcttcgt tgacagcatg tggttcaagg   1756440
ttacggtaac gggccatacc agtaccagct gggatgatct taccgatgat aacattttct   1756500
ttaagtccaa ggagatggtc tttcttacca cggatagctg cgtcagtaag gacacgagtt   1756560
gtttcctgga aggaagccgc tgacaagaaa ctgtttgttt caagtgaggc tttggtaatt   1756620
cccataagga ctgggcgacc tgtcgctgga actccacctg cgataaggac atctttgttg   1756680
gcatctgtaa agtcattgat atccatgagg gtacccatga gaagatctgt atcacctgga   1756740
tccatgacac ggactttacg gatcatttga cgaaccatta cctcgatgtg tttgtcaccg   1756800
atttctaccc cttggctacg gtaaactttt tgtacttcac cgagaaggta cgtttcaact   1756860
gacaagacat cacgaactgc aaggagacgt tttggttgga tagaaccttc tgtcagagca   1756920
gcaccacgcg ctacttggcc cccaacttcg acacgcatac gagctgtaaa tggaacgaca   1756980
tattcacctt cgccagtttc acccttaaca aagactttct tggtacgagt tgatgcatct   1757040
tcttcgatag cagtaacttg tcctttaacc tctgtaataa ccgcttcccc tttaggattg   1757100
cgggcttcaa agatttcttg gacacgagga agaccctgag tgatatcggt atttgaggca   1757160
accccacctg tgtggaaggt acgcattgta agctgtgtac caggttcccc gatagattgg   1757220
gcagcgattg taccaactgc ttcaccaact tcaaccgcat caccagtcgc caagttgata   1757280
ccgtaacagt gacggcagac accgtgacga gtgttacatg taaatacaga acggatagtc   1757340
acttcttcca caccagcatt gacaatttca cgcgccttgt cttctgtaat caattcattt   1757400
ggaccaataa tcactgcacc agtttctgga tgtttaacag ttttcttagt gtaacgaccg   1757460
ttgagacgct cttcgagaga ctcgatcatc tcttttcctt ctgcgataga acggatcaag   1757520
agaccacggt cagttccaca gtcgtcctca cggatgataa cgtcttgggc aacgtcgacc   1757580
aaacgacgag tcaagtaacc tgagtcggct gtcttaaggg ccgtatcggt cataccttta   1757640
cgagcaccgt gagttgagaa gaacatttcc aataccgaca aaccttcgcg gaagtttgaa   1757700
aggattggca attccatgat acgtccattc ggagcagcca tcagaccacg cataccggca   1757760
agctgtgaga agtttgagat gttaccacgg gctccagagt ccatcatcat aacgattggg   1757820
ttcttaggat cttggttagc aatcaagcgt ttctcaagtt tttcacgggc agcacgccat   1757880
tcagctgtaa cagcattgta acgctcgtcg tctgtgatca taccacgacg gaattgtttg   1757940
gtgatttgtt cgacacgttt gtgtgattct tcaatgattt cagccttgtc atcaacgact   1758000
gggatatcgg caatacccac tgtcaatcct gcaagagttg agtggtggta accgaggttc   1758060
ttcatgcggt caagtagggc agaagtttct gtcgtacgga aacgtttgaa gatttcagcg   1758120
atgatatttc caaggttttt cttcttgaat ggagggttga gctcaagatt gctgatagct   1758180
tccttgatat ctccaccaag tggcaagaag tatttagctg gaacaccttc tgtcaagttg   1758240
gcattgtttg gttcttgcaa gtatggtagc ccctctggca tgatatcgtt gaagagaatt   1758300
ttaccaactg ttgtaagcaa gaccttatgt ctttgctctt ctgtccaagg cttgttgagg   1758360
ctgtctgttg cgataccaac acgtgagtgg aggtgaacat aaccattgcg gtaagccata   1758420
accgcttcgt cacggtcttt gaagaccatt ccttcacctt cgcgaccagc ttcttccatg   1758480
gtcaagtagt agttacccaa aaccatgtcc tgagatggag taactaccgg tttcccatct   1758540
ttcgggttca agatgtgctc agcagctagc atgaggatac gagcttctgc ttgtgcttct   1758600
tctgaaagtg gtacgtggat ggccatttgg tccccgtcaa agtcagcatt gtaggcttca   1758660
cagacaagtg ggtgcaagcg aagagcctta ccatcaatca agactggctc gaaggcttgg   1758720
atacccaaac ggtgaagggt cggtgcgcgg ttcaaaagca ctgggtgttc tttaatcact   1758780
tcttcaagga tatcccagat acgctcatct ccgcgttcca ccaagcgttt agctgctttg   1758840
acgttttgca cgatatcacg ggcaacgatt tcacgcatga caaatggttt aaagagttca   1758900
atcgccattt cacgcggcac accacattgg tacatcttaa gagttggacc aacggcgata   1758960
actgaacgtc ctgagaagtc aacacgttta ccgagcaagt tttgacggaa gcgtccttgt   1759020
ttacctttaa gcatgtggct caatgatttc aatggacggc tacctggtcc tgtgattgga   1759080
cgaccacgac gaccattgtc aatcaaagcg tcaactgctt cttgaagcat acgcttctca   1759140
ttttgaacga tgatacctgg tgcatttaac tcaagcaaac gagccaaacg gttgttacgg   1759200
ttgataacac ggcggtaaag gtcattcaag tcagatgagg caaaacggcc accatccaac   1759260
tgcaacattg gacgaagatc tggtgggata accggaagga tgttaagaat catccattca   1759320
ggtttgtttc cagacttgta aaaggcatcc aaaacatcca aacgacggat ggctttgaca   1759380
cgcttttgtc cagtagctgt tttcaattct tctttgagtt cagcaatttc tttttcaaga   1759440
tctacttgct tcaaaaggtc ttggatggct tccgcaccca tcttggcaac aaatgaacca   1759500
taaccatatt cacgcaagcg ctctcggtat tcgcgctctg tcatgataga cttgtgctca   1759560
agtggtgtat ccttaggatc aatcaccaca taagccgcaa agtagataac ttcctcgagg   1759620
gcacgagggc tcatatcaag ggtcaagccc atacggcttg gaatcccctt gaagtaccag   1759680
atgtgagata caggagcttt caattcgata tgtcccatac gctcacgacg aactttcgta   1759740
cgcgttactt caaccccaca gcggtcacaa acaattcctc tgtaacgaat gcgtttgtac   1759800
ttaccacaag cacattccca gtcttttgta ggaccaaaga tcacttcatc aaagagtcct   1759860
tcacgttctg gtttcaaggt acgataattg attgtttcag gttttttgac ttctccataa   1759920
gaccatgaac ggactttact tggagaagct agggtgattt gcatactttt aaaacgattt   1759980
acatcaacca ctatttcttc cctttctatt ctaagtgaac tgcttattct tgttcagcag   1760040
cttcttctgt tgcttccgct tttgttgctt tctcagcttc ttcagcttca aaggctgctt   1760100
tagcctcttg ggctgctttt tcgcgggctt tttcaaggtc atctacgtgg atgacatctt   1760160
cgtccattcc ttcatccaag tcgcgaagtt ccacttcttg gtcatcttcg tctaggacac   1760220
gcatgtcaag accaagagat tgcaattctt tgacaagaac tcggaaggat tctggaacac   1760280
ctggttttgg aattggtttg ccttttgtaa tagcttcata ggctttcaaa cgtccgttga   1760340
tatcgtccga cttgtaagtc aagatttctt gaaggacatt tgacgcaccg taggcttcaa   1760400
gagcccaaac ctccatctca ccgaaacgtt gtccaccaaa ctgagcctta cctccgagtg   1760460
gttgttgggt aacagttgag tatggtccga ctgaacgcgc gtgcaattta tcatcaacca   1760520
tgtggtggag tttgatcatg tacatgactc cgacagaaac acggttatca aacggttcac   1760580
cagtacgtcc atcgtaaagg atcgttttgg catcgctatc catacctgct tctttaacag   1760640
ttgaccaaag atcttcagaa cttgctccat caaagactgg tgtagcgatg tgaataccaa   1760700
gagtacgagc tgccatacca aggtgaagct ccataacctg accgatattc atacgtgatg   1760760
gtaccccaag tgggttcaac atgatgtcga ctggagttcc gtctggaagg taaggcatgt   1760820
cttctacagg aacgatacga gagacaaccc ctttgtttcc gtgacgtccg gccattttat   1760880
ctccgacctt aatcttacgt ttttgagcga tgtaaacacg aaccaacatg ttaacacctg   1760940
attgcaactc atctccattt acacgtgtaa agatcttaac atcacgaacg acaccatcgg   1761000
caccgtgtgg tacacgaaga gaagtatcac gcacttcacg agacttgtct ccaaagatag   1761060
cgtgcaagag acgttcttca gctgaaagat ctttctcacc cttaggtgtt actttaccta   1761120
caagaatatc accttcttta acctcagcac caatacggat aatccccatt tcgtcaaggt   1761180
ctttgagggc atcttcacca acgtttggaa tttcgcgagt gatttcttca ggcccaagct   1761240
ttgtatcgcg cgtttctgat tcgtattctt caaggtgaac agatgtgtag acatcgtcct   1761300
tcaccaagcg ttcgctcatg ataacggcat cctcgaagtt gtaaccttcc caagtcatgt   1761360
aggcaacgat tgggttttgt ccaagcgcca tttctccatt ttccatagaa ggtccgtcag   1761420
cgatgaaatc gcctttttca acgacatcac caacttttac gagagtgcgt tggttgtaag   1761480
cagtacctga gtttgaacga cggaattttt ggatgtggta aacatccaat gaaccatctt   1761540
cacgacgaac ttctaccttg tcagcatctg cgtaagtaac tttaccatca tactgagcaa   1761600
tcacagccgc accagaatcg tgggctgctt ggtattccat accagtacca acgtaaggtg   1761660
cctgaggatt aatcaatggc acagcctgac gttgcatatt ggctcccatg agggcacggt   1761720
tggagtcatc gttttccaag aaaggaatac atgctgtcgc aacggcaact acctgttttg   1761780
gtgaaacgtc catgtagtca acaatattag ctggatactc ttggttgacc ccttggtgac   1761840
gtcccatgac aatcttctca gcaaaggttc catcttcatt cagacgagag ttagcctgag   1761900
ctacagtata ttcatcttct tcatcagctg tcaaccaaac aatttcgttc gtgacaacac   1761960
ctgtttcacg gtcaacctta cggtatggtg tttgaacaaa accatatttg ttcaagtgtc   1762020
cataagatga caagttattg atcaaaccga tgttaggtcc ttcaggtgtc tcgattggac   1762080
acatacgacc atagtgagtg tagtgcacgt cacgtacttc atatccagca cggtcacgag   1762140
tcaaaccacc aggtcctaag gctgacaaac ggcgtttgtg agacaactca gaaagcgggt   1762200
tgtgttggtc catgaactgt gacaactgtg atgaaccaaa gaattcttta actgcagctg   1762260
ttacaggacg gatattgata atttgttgtg gtgtcaagac ttcattgtcc tgaacagaca   1762320
tacgttcacg gacattacgt tccatacgag aaagtcccaa acgtacttgg ttggcaagca   1762380
attcaccaac cgcacggata cgacgatttc caaggtggtc gatatcatct acacggccaa   1762440
gtccttcagc caagttgagg aagtagctca tctcagcaag gatatctgca ggagtcaccg   1762500
tacgaacctt gtcatctggg ttagcattac caatgatcgt tacgacgcga tctggatcag   1762560
ttggagcaat aaccttgaat ttttgaagaa caacaggctc agtcacaacg gctgcatcgt   1762620
ttgggatgta gacaatcttg ttcaagtcgc catccaaatg gctttcaatg ctttcaatca   1762680
cgctacgagt cataatcgta ccagcttcta ccaagatttc tccagtttca gggtctacca   1762740
atggctctgc aatggtttgg ttgagcaaac gtgttttaac attgagtttt ttattgattt   1762800
tgtaacgacc aactgctgcc aagtcataac gacgtgggtc aaagaagcga gctacaagca   1762860
agctacgtga gctttcagcc gtcttaggct cacctggacg aaggcgttcg taaatttctt   1762920
tcaaggcttc gtctgtacga gagtccattg gattcttgtg gatatctttt tcaacagtgt   1762980
tgcgaaccaa ttcgctgtca ccaaagatat caaagatttc atcatcacct gagaaaccaa   1763040
gagcacgaac caaggttgta aatggaatct tacgagtacg gtcgatacga gtgtaggtga   1763100
tatcttttga gtcgctttca agttccaacc aagctccacg gttagggata acagttgaac   1763160
catagcccac cttaccattt ttgtctactt tgtcgttaaa gtaaacacct ggtgagcgga   1763220
ccaactgaga aacgataata cgttcaccac cattgatgat gaaagtaccc atttctgtca   1763280
tgattgggaa atcaccaaag aaaacttctt gggtcttgat ttcgcttgtt tctttattga   1763340
tcaaacggaa ggttacaaaa attggtgctg agtagctagc atcgtggata cgagcttctt   1763400
ctagcgtata ttttggttcc ttgatttcat atccaacaaa ttccaactcc attgtgtctg   1763460
tgaagtttga aattggcaat acatcttcaa acacttcctt aagaccgtgg tctaggaaag   1763520
ctttgaatga gtcagtttga atttcaatca aatttggtaa gtcaagaact tctttgattc   1763580
ttgaaaaact acgacgggta cgatgtttcc cgtattgaac gtcatgtcct gccaagatga   1763640
ttctcctttg taaataagtt ccaagccttg tcaatcaggc ttttctaatc gtcatatggt   1763700
tgtaaacccc ttatcaccgt gtcctcttga cgaattttca gaatctttaa gcctctgtta   1763760
caaatgctca aaatcttgaa aaaaagcaca aaaagagcag ctaaatctga ctttttcaga   1763820
agatttaact gctgtgagcc ttgtctggac aatatttcag acaaaaccta cgacaaatga   1763880
ttacccatat tataccctat ttagctagat ttttcaaggg gtttcagtag gtttttggta   1763940
aattttttcc catagaaaac ttggcatcac attcgaatca cgctatggta caaaaaactg   1764000
aaaaaactat tgactgaaaa tcattttcaa ggtataataa taaacgttaa ggcggtatag   1764060
ccaagtggta aggcacggct ctgcaaaagc ttgatcgtcg gttcaaatcc gtctaccgcc   1764120
ttctataact tgatttatca ggtttcaaat gaacagaaag cccaatttga agggcttttt   1764180
ttattttccc tcgaataaat acgtataact ttaaaaactt ttggagcgag tttgtggcag   1764240
agttctttcc atggcataat tcccttttga aatcaattga aaaaagcttc gtcacgcctg   1764300
gtgacaaaag cctctagttt attctgtttc ttcttctatt tcgacttctg tgatttggac   1764360
ttttaccttg gtaacacgtc cattcttcac tttatcattg gttaagataa actgtttgtt   1764420
ttggctgacc aattcatagc tgagtttctc agtcgttgga atagttccca ctcctgtcaa   1764480
ataataacca gcgatagtat caacgtcatc actttccagt tcaacatcaa agtaattatt   1764540
gaaatcattg agggtcatag ttccttgaac aatgtaggta tcctcgccaa tctgatgaac   1764600
atctattgct gctttgtccg tttcatcatc aatttcacca acaatttcct ctaagaggtc   1764660
ttccaaagtc accaaaccag ccataccacc gtattcatcc agcaagattg ccatttgtct   1764720
ttgggtattt cgcagttctt ttagcaagtc atccacaaaa atagtttcag gtacaaaaag   1764780
tggatcttgt aaaattctct tccaaacaat attgtcaaaa ccgtccacaa agcctgcctt   1764840
aaggagactc ttggtgtgaa tgattccaat tacattgtcc ttatccccat cataaaccgg   1764900
gatacgagaa taattttgtt ttaaaatact ttggataatg gcttgactat catcctgaat   1764960
atccaccata aaggcatccg ttcgaggaac cataacctct cgtgccatca gttcatcgag   1765020
cgaaaagaca ccttgtagca tctcaatctc atcagcatcc aatgtttctt cactatttgt   1765080
cagcatatag gcaatttcat cacgggtcat cttttcatcc gcatcatcga atgacatagg   1765140
agtcaaatgg ctcaagaaat tggtcgaagc agctaaaagc caaacaaaag gactgactag   1765200
ttttccgatc ccaatgataa tcggcgctgt acgaattgcc aaggcatcct ttagattaag   1765260
agcgattctc ttaggatata attccccaaa aacgatggaa atataggtca aaaatgccaa   1765320
ggatagaaaa gttgccacgg cttgtgctgt ttcgccattc ccaagccaag aggcaatcac   1765380
acgtcctaga gtatcagtta aactcgcccc tgataagatt gtaatcaggg tgattcctac   1765440
ctggatggtt gataaaaagt ggttaggatt ttctagtacc ttcagcaggc ggatgtagcg   1765500
tctgtctcct tcttccgcct tttgttcaac tcgggcacga ttaagagaaa ccatggccat   1765560
ttctgtggct gagaaaaagg catttaatac cgtcaagata aacaataaaa caaattgtag   1765620
caacaaattc tgactacttg ggtcttccat agttcttctc ctaaaatagt atcttatcct   1765680
ttattatatc acaaaattta atccaataca tattattttt tcttaccgta acttctcaaa   1765740
gtaacttcca tctctctccc aaaactggaa gttagtttta gaagttgcta ttttttctta   1765800
gtacctgttc tagtcctgct taaactagta aaaagaactc ctacatccat aagtgacata   1765860
ggagtttagg cttatctttt actgagttac agttacttct ccagttcggt aatccagttg   1765920
aagtcccttt tgaacattgg gaactagaac attgaattcc aattctccat ccgaagactt   1765980
ggcttcaatc tgtgaagctg agggaactaa atcctcgttt gaagcgtagt aaagggttac   1766040
acggtaacgg acacgcttgt tttggtccaa ggctttacgc accttgcttt catagtagtt   1766100
ttgaccagtc gaatactcgg cttgtgcctg atttgcccag gctgtctgaa cagcaatgtt   1766160
tttaggattg cttgttgagg catcaaaacc atccaaacca ccgattaagg catagcctaa   1766220
caaatgacct ctatcgactg catgggtata agagcccttt agattcttga cctgatgcca   1766280
acctggagga gtccaagaag ttgaaccatt cccagtttct ttacgattct tgtactgacg   1766340
agtggcctta gacaagaggg cattagctac ggttggaaca gtttccttgc ccactgtctt   1766400
tgttttattg tcagcgtagg gcttacttga aaccttggca tctagatttg ttttattacc   1766460
attgacgata aaagcacctg agccattcca ctccagactc ccctttattt gactcttgac   1766520
tgcgtctgtt aagacactct ctgccaatgc ttgactagga gcttcagacg cttgtttttt   1766580
ctgactaaga ttggttttgg gactattagg tgccgacggc atctgcttga tataatagct   1766640
ccctgtagac aaaagcaata acactagcag tccgattagt gtctgtcttg tttttttgtt   1766700
catatttctc cttatcttta gaaaaaggct ggttctccag cctaatttcc tgtaaattta   1766760
tgaatcaatt cctgccattt tgctggagac aggatagccc atggatcttg acccttgccc   1766820
aagattccat aacctaccat taaaccgatt cctagagcca gagtacctaa aatcagtact   1766880
atgatgacta aaagtaaacg cttgactacg tagcttgatt tcttattcat cttcatcact   1766940
tgcctcaatc cgctgaatct tagcacctag ctgcgccaac ttctcatgga aaccgtagta   1767000
acctctatcc aagtgaacca atttaccgac cacagtttct ccctgtgcta ccaaacctgt   1767060
caaaatcaag gccgcactgg cacgaaggtc agttgaaaga acttctgctc cctgcaaagg   1767120
ctgtccacca acaatacgag ctgtatcacg gataatctca gaatgcaagc ccatgcggcg   1767180
catctcttct aggtgttgga aacgattttc gaaaactgtc tccaccatgg ttgattcgcc   1767240
ttttgcaact gtcatcaagg ctgtaaattg agcctgcata tctgttggaa atcctgggtg   1767300
gggcaaggtt ttcacatgaa cagcttttag attttctagt tgagaacgaa cacgaattcc   1767360
ttcgtcttct tcaattactt caacacccat ttcaagtaac ttggcaatca agggacggtt   1767420
gtgctcccag acagcgtctc gaatcaagac atcaccacca gtcatggcag cagctaccat   1767480
aaaggttcct gcttcgatac ggtcttggac tacattgtga gtcgtaccat gaagtttctc   1767540
aacaccagta atggttatag tctctgtacc agcacctttg accttggctc ccatttcatt   1767600
aaggagaatg gctaagtcaa caatctcagg ctcacgcgca gcattctcaa tcactgtcac   1767660
cccatcagcc agagtcgctg ccatcatcaa gttctgcgtt gcaccaacac ttggaaagtc   1767720
catatagata tgagcaccat gcaagcgttc tgccttggct tcgatgtaac cagctgtctg   1767780
actaatctta acccccatag cttccagacc tttcaaatga agatcaatag gacggctacc   1767840
aatcgtacaa ccacctggca tggatacctt ggcatgaccc acacgggcaa ggattggccc   1767900
taatacaacg atggaggcgc gcatcttgct gacatacttg taaggggctt cctcagtgat   1767960
gtcgccagta gcatccacct tgacaagatg agcttcctca tcaaagtcaa ccttggcatt   1768020
caaaccacca actacctgat tcataataaa gacatccgac aaaatcggaa cattctgcaa   1768080
gacggtcttt ccttcacttg ctagaatagt cgctgccaac aagggtaaga ctgcattttt   1768140
tgctccctcg atcgtcacgc ttcctaccag acgattatcg ccaccttgaa ccacaatttt   1768200
atccatactc gtttccttta ctcttgattt cataataatc ctctaagcgc ttcttgccac   1768260
aaatgataca ggctaataaa gaaagaactc aggatgtagc ctatgacaat gctaaaaaag   1768320
gctactaata aacgaacttt tcttgtatta tcatctgtca cttttaaaac cttctcccat   1768380
ctaacaagat cctttaaaag gtaaaaactc acataaataa agaacatatg actacttaga   1768440
gtgaataata attgaaccat ttgactatta taccatcttc tctgtttgtg cgctagtttg   1768500
gaaacttcac tcaaaaatta gggattgttt ttcaagtaat caatcgcatc ttgtagggtt   1768560
ttaacgggca cgattttcat atccgtcttg attgttttag ccgcttctag ggctgtttgg   1768620
tagttgtttt tcgcgtccgg atgcgccttt tgttcttctt cgctaacagg gttatcagga   1768680
gcaaagaaaa tagcagcacc tgccctagcc gaagctacaa ccttcttatc aatacctcca   1768740
atgtctccca cattaccatc gcggtcaatg gtacctgtac cggcaacaat acgaccatta   1768800
cgaagatctg ggtgagctat ttgagtatag atagctagac taaacatgag accagcactt   1768860
ggaccgccaa taccagctgt tgaaaagcta attgggacat tgctgattac ctctgtacgg   1768920
tcaatcaagc cgattccaat tccatttttg ccattttcca aggtgatgat ttttccttct   1768980
gcagacttgg tttgcccatc ctcttcatag gtgaccttga cggaatcccc taatttttga   1769040
gaactgacgt aatcaatcaa gtctttggaa ctatcaaagg tctgatcatt gactgctgtg   1769100
actgtatcag agatattgag aatcccttta aaggttgaat tatccgtcac attcaaaaca   1769160
taaactccaa agtacttgag ttcgatatcc ttaccagctg tttttagtcc ttgatacttg   1769220
gccatatttt gcgatgtttg catgtagaat tgattgattc gcataaattc aacatcggaa   1769280
gaaccacctg tagtctcctg agcactacga atatctgtaa aaggtgtcaa ccaagcataa   1769340
atcatatgag ctaaagtggc atgttgaaca ccaaccgtaa cgaattgata ggcaccagct   1769400
tccttatctt ctgtgtcatt tactttaagg acttggcgaa tatcttccga accacctgga   1769460
acctctatat aataaggcaa gggcactaca aatgccaaga aagtcacaat caaggccgca   1769520
atgacgtata agggccatct aatctttttt ttcatttctt atttcctcca aaatactctc   1769580
gggaacatag caggcaatat cctgaccaaa cttcaaaagc tctctaacgc ctgatgaact   1769640
gatatagaga tgttcaggtc gactatgtaa ataaatagtc tctatatcag aagacagctg   1769700
atgattgtag taatcaaaac tggcttcata ttgcaaatcc gacgcatttc tcaaacctcg   1769760
cactaggcaa gtagccccca gtctttttgc gacatcgacc accaatttat catgagaaga   1769820
cacgacttta acatttccca aatgtttcac agccttttct aacccccgtt tacgattttc   1769880
aagagggaga aatccttgtt tgtggggatt aaaaaaaata cccacataaa gcttatcaaa   1769940
aagtctgctc gcccgttcaa tgatatccag atgcccattt gtcatcggat caaatgagcc   1770000
tgtgaataag ccaatcttat ctgacataga ctgtcacctt actaattcca taaatctttt   1770060
ccttccagat acccagacag gcaatttctt ctggaagttc aacggcttta tccgtctcgc   1770120
acacaaccat aacatcttca gaaaaaagct ctctctcagc cattttttca atatctgcta   1770180
cgatttgttc cttggcatag ggagggtcta agaaaacgag gtcaaattcc ccagatacct   1770240
gttccaatgc cctttctgca tccatcttga ggagttgaaa ttttccaact tccttggtca   1770300
tctggatatt ttcagccacg atggtctgag ccttacggtc tcgctccacc aaaacagcac   1770360
tggacatgcc acgcgatact gcttcgatag ataaaccacc actacctgca taaaggtcca   1770420
agactcgtcc cacttcaaag tagggaccaa tcatgttaaa aatggctccc ctaaccttat   1770480
ccgaagtagg tcttgtcgtc ttgccttcta gtgtcttgag gggacgtccc ccatagattc   1770540
ctgatacgat tttcatactg tttattatac caaattatag acaaaaagag aaagaaaacc   1770600
gaaccttgcg gttcgattct ctacaaaata ttttcgtaag tatcgcggac ttcttgaggc   1770660
caaacacttg tttgcacttc tccgatgtgt ctcttgcgaa gtaggaacat ggccatacga   1770720
gattgtccaa ttcctccacc gattgtcaat gggaatagac cattcaacaa agacttgtgc   1770780
cattccaatt ccaagcggtc ttcatcacct gtaatttcca cctgacgtct aagagtttct   1770840
tcatctacac gaattcccat agaagacaac tcaaaggctc cacctaaaga ctcattccag   1770900
acaagaatat caccatttag acccttgtag ccattctcag actcgcttgt ccagtcatca   1770960
tagtctggtg cacgtccatc gtgcggttta ccatctggca actcgccacc gataccaatc   1771020
aaaaagacgg ctccaaattc tttacaaatc gcattttcac gttctttcgg tgtcaagtct   1771080
gggtagcgtt ctaccaattc ttctgtatgg ataaaggtaa tttgttttgg caagatagac   1771140
tcgatgtcat agcgggcttc aacagctagc tcagtcaggc gaatagcctt ataaatcttc   1771200
tcaactgttt cttttagata aacgatgtta cgcttaccat ttgggataac cttctcccag   1771260
tcccactggt caacataaac agagtgggtt gcatccaagg aatcctcatc tggacgaagg   1771320
gctttcatgt ggacaaagag accctctcct tcaccaaagc caaaacgagc caaggtgtgg   1771380
cgtttccatt tagcaagtga gtgcaccact tcataagtag catcagggat ttggagaacc   1771440
ttgaccgata ctggattttc cacaccagac aggttgtcct gcattccgtc accgacctta   1771500
ctcaagatag gaccttgaac ttcgacaact tctagcttat ctttcaaata ctgggtaaaa   1771560
gtgtttttga caaaggaaat ttcttcttgt tgatggataa aacttttctt catagacaac   1771620
tcctcaaaaa tttaataaac gtattataca cctatttcca agaaaagaaa agagaaaatt   1771680
taaaaaaaat cagtgtcact caaaacactg atttcataga ccttttagtc attgcgacca   1771740
aagatacgta gaatacttag gaaaagattg ataaaatcaa gatagatgct gagagccatt   1771800
gacaccaccc agcctgtcgc tacacgacct tgtgattgtt cataggcgag gcgaatcttt   1771860
tggttatccc aagcaatcaa ccctgaaaaa accaaaacca tggctacgct aatcatataa   1771920
tcaaagaagc cactagccaa gaaaatattg actaccatag caatcagtaa accaatgaga   1771980
gctgccatca ttgctcgacc aatcccactc aagtctttct tggtaaagat accaactgcc   1772040
gccatgacaa agaagagaag ggcgctcgat acaaaggcag ataaaactgt acccggagta   1772100
tagaaagcca ccacaaaact aagggtaaag ccgtttaaaa cggagtaaag taaaaatact   1772160
ggaagagcag ctggactatt tcttgaagcc atgctactgg caacgaaaac caaagccaac   1772220
tccgcaaaag tagcaatggt caaccagaga cgcccctgca tcaacaagta aaccaactga   1772280
gactgaaaga ccgtcaacat aaggcctgat accaaagcag atagtccgat tcccagacca   1772340
acaaaggcat aaaccttagc gtaaaattga ttgagacctg cacggtcatg tataatagtg   1772400
tgattcatcc atttctcctt ttctgtgaac atctttcctt gattataaca aaaaaagtta   1772460
aaattagctt aaatggaaga ttaaaatacc ggctgcaacc gcaacattca aactctcggc   1772520
ctgccccttc atgctaatat ggaccaactg gtctgcactt tcagccataa ggggactaat   1772580
tccttgaccc tcatttccca taactagtac aaaattttct atagaaggca gttctctgta   1772640
atcaacagaa tctttagata gggttgttgc taacactggg atagctacct ttttagtttc   1772700
gtcaagaagc gcttgactag tcatccggta aatgggcaga tggaaatgac taccttgcat   1772760
ggaacgtagg gttttgagac tgtagatgtc tgccgactta tctgaaacaa tcactcctgt   1772820
aaaacctgct gcatccgcag ttcgaatgat agttcctaca ttaccaggat cttgcacatc   1772880
ttccaaaaac aagaacttgc cctgactcaa atcagcttgt cctacttctt ctttttgaac   1772940
cacggccaca attccctgtg gagtctgaga atccgccaaa tctagcaaaa tatcctctga   1773000
cacccagaca gtttgcgaaa aagttgctaa ctgatctcga taattttcta gggtaaagat   1773060
tttctcaatc gtcactccag cttgaacagc ttcttcaaac aagtgccagc cttcaatcaa   1773120
ataggctgac ttgcggtatt ttttttggtg taatttcttg gtatttttta ccacagaatt   1773180
ggcttttgag gttataatag tcatagaaat attataacac aatcaaaggg gtttggtatg   1773240
caaaaggtta gaatgattgc ccaaggtagg gtgcagggag tcggctttcg ttggggtgtt   1773300
tatagcctgg cccttgaaat cggtggcatc acaggtcggg tatggaataa cgacgatggc   1773360
acagtggaaa tcttagccca agcagactca tcagctatta tggcaaaatt tatccaagaa   1773420
atccgaaaag gaccgacacc tttttcaaaa gtcagttact tagatgtcaa actgagcaac   1773480
tttcctccct accctgactt taaaatcgca aattaggtct ccagaactat tgtatatttt   1773540
gtaaaaaaac agtagaatag aaaggtataa tttttaaaga aggaataaaa acagtgaaat   1773600
ctattaaacg ttttgcactc tcggctatgg gagtggctat gttgcttgtc ttgactggct   1773660
gtgtcaatgt cgataaaacc acaggtcagc caacaggatt tatttggaat acgatcggag   1773720
cgcctatggc tgaagccatc aagtacttcg ctactgataa aggtctaggc tttggtgtcg   1773780
ctatcattat cgtaaccatt atcgtacgct tgattatctt accacttggt atctaccaat   1773840
catggaaggc aacgcttcac tctgaaaaga tgaacgccct caagcacgtc cttgagccac   1773900
accaaacgcg tctcaaagaa gcgactactc aagaagaaaa actcgaagcc caacaagctc   1773960
tctttgctgc tcaaaaagag cacggtatca gcatgtttgg cggtgtagga tgtttcccta   1774020
tcctccttca aatgcctttc ttctctgcta tctactttgc tgcccaacat actgaagggg   1774080
ttgctcaagc aagctaccta ggcattcctc taggttctcc aagtatgatt ttggttgcct   1774140
gtgctggtgt cctttactat cttcaatcgc tcctttcact tcacggagta gaagatgaaa   1774200
tgcaaagaga acaaatcaag aaaatgattt acatgagccc actcatgatc gtcgtcttct   1774260
ccctcttctc accagctagt gtcacacttt actgggttgt cggtggtttc atgatgattc   1774320
tccaacagtt tatcgtcaac tatatcgttc gtccaaaact tcgcaaaaaa gtccgtgaag   1774380
aactagccaa gaacccacca aaagcaagtg ctttctctaa accaagtgga cgaaaagacg   1774440
ttacccctga acaaccaact gctatcacaa gcaagaaaaa acacaaaaat cgcaacgctg   1774500
gaaaacaacg ttcgagataa gaagaaaaag gcttagctga tttgctaagt ctttttgcaa   1774560
gtcaaaagcc cgatgtttcc atcaggcttc ttttctatcc atgtacacgt ttcatataat   1774620
cttgataact ttcggtatcc atgagttgtt tagcgttctt gacgcgatct gctgttggtg   1774680
gtttgactcc ttcgagggaa tatggaattc caagttcacg ccacttgaac tcacccatgg   1774740
tgtgataagg tagaatttca aacttatcaa catttttgag ggtcttgacg aacttaccaa   1774800
gttcaatcaa gtcatcatct ctgtctgtca atcctggaac tagcacgtgg cgaatccaga   1774860
caggttttcc aatatctgat agatactggg cacaagccaa gatattttta ttggtttggc   1774920
tagtgacaat cttgtgctgt tcttcgttga tttccttgat atccaaaaga accaagtcag   1774980
tgacagccat gagtttgtca aacttctcaa ggtaacgtgg tttattacgg aaaggaagag   1775040
cacaggtgtc caaggtacag tggattcctt gttccttagc cttggtgaag agagcaatca   1775100
ggaaatcaat ctgcaagaga gcttctcctc cactgactgt aatcccaccc ttatttcccc   1775160
agaaaccacg gtagcgcaag gcctctgtca agacatcatc taccgtccgt tcacgtgact   1775220
tattggactc catagcccaa gtgtctgggt tgtggcaata ctggcaacgc atgtgacagc   1775280
cctgcaaaaa gacaataaag cgaataccag gcccatctac tgacccaaag ctttctgtcg   1775340
aatgcaccat tcctgtcact tgtccataat caattgtttc ttcagacata tcgttacctt   1775400
ccttgaaaac gttttatagt tttattatat cacgacttga aggaaaaaca agatttttgc   1775460
ctatttttta gaaagcaatc tgtttttcaa tttcattttc aatctattat cagattattc   1775520
ttcaaaatcg aagccatata aggttgcaaa atagtcctca gggcgctctg cacggcggat   1775580
ttgacgggct ttaccttctt cggtatagag gatttccgca gaacgtaatt tggcattata   1775640
ctggtagccc attgaaaatc cgtgggcacc tgtatcatga atgaccagca aatcaccgat   1775700
ttctgtatga ggcagttcgc gattaactgc aaatttatca ttgttttcac agagtgaacc   1775760
gaccacatct accacttcag ctggtccatc tggatgggtc acgttgctaa tatgatggta   1775820
agctccgtac atagctggac gcatgaggtt gactgctgag gcatccacac ctagataggt   1775880
acggtaggtt tccttcttat gagtgactct tgtgactaga gcaccgtgag gtgccagcat   1775940
aaaacgaccc aattcggtga aaatcttgac ctgaccaaga cctgctgacg taagaacctc   1776000
ttcatacacc ttacgaactc cctcaccaat caaggcgata tcgttcggct cctggtctgg   1776060
atgataatta acaccaatac cgccagaaag attgataaag tctagcgaaa tgcccaactt   1776120
ttccttgatt tcaacagcca gttcaaagag ctgacgagcc aactctggat aatagagatg   1776180
ggtcacggta ttggacgcta ggaaggagtg aatcccaaaa gtcttggctc ctttttcctt   1776240
caagatagca aaggcttcaa agagctggtc cttggtcatg ccaaacttag cctccccagg   1776300
attgtccata atgtctgtcc ccagttcaaa aacgcctcca ggattataac gacaagagat   1776360
gatttctgga atgcctgcta ctctctccag atgttcaata tcttcaaagg catccaagtt   1776420
aatggtcgca cccaattcac gtgcataggc gtattccttg tctggcgtgt tgttggaaga   1776480
gaacataatc tcagaaccca gaaagtccag tttatggctc atcaaaagct ctacataact   1776540
agagcagtcc acaccacaac cttcttcttg gagaattttc aaaatagctg gagttggagt   1776600
agccttaact gcaaaatatt ccttaaagcc cttgttccac gaaaaagctt ggttgacggc   1776660
tcttgccttc tcacgaatcc ccttctcatc atacaagtga aagggagtcg ggaactcggc   1776720
aacaatcgct tctaactctt ctctattgat aaatggtgtt ttcataagct tccttctatt   1776780
ctgtttgcaa agaaaggctg ggacaatcgt tccaaccttt agttctatct cttatttatc   1776840
ttcgtcaaag atattgccaa cctcaacatc gatggcttgg ttcttgacat caatattggt   1776900
taccttcaag agtgacttgt agtcaaactg cttttcacgt tcttcttggg cattgtccgc   1776960
aaagaccgct acacctgcca gttctgagtc gaactcgcgc aagagactaa tcataccatt   1777020
gaccgttccg ccacctttca agaagtcatc cacaatcaag acacggctgc ctgccttaag   1777080
actacgtttt gaaaggaaca ttttctcgat acggtcacca cttgaacctg aaacatagtt   1777140
gacgctaaca gttgaacctt cggtaatttt caggtcacgg cgcacaatga caaaagagac   1777200
attgaggaca ttggcaactg catttgcaag tggcacaccc ttagttgcta cggtcataac   1777260
cgcgtcaatt ttttggtcca taaagctttt ggcaataata cgaccaatat ttttcaagat   1777320
ggctggtgtg ctaagcaaat cagacagata gatataacca cctggcaaga tacggtcact   1777380
ttctgacaac ttggtacgca agtcttcaac catttcctta gcatcctgac tcgaaataga   1777440
cggtgtgaag atgacacctc cgccagcccc agtcactgtc tggatatgac cgatttcaat   1777500
ttcctcaaag gcgcgtttga taatgacgat atcttctgag atggatgatt tagcagactc   1777560
atacttttca gcaaaagtat tgagactagt tagtttataa ggattattaa tcaaatagtt   1777620
ggaaatgaca accatccgat cacttcttct taatttcatt tctatttcct attccatttt   1777680
tattcaaaaa atcaaaaagc aaactagaaa gctggtcgct ggtggttcaa aacactgttt   1777740
tgagattgtc aatagaactg acaaaccctg taatatacct gcatatatac atacgacaag   1777800
gcgatactac cctagtttga agagattttc gaagagtatt catttttgtc ttttacttat   1777860
tataccatat tcacataaaa aaacgaacat tcttatccta aaaaatgctc atttttctta   1777920
aattattaat ctaaatctgg tttatagaag gaacgattat ccatagcgaa gattttattg   1777980
gtcatctctc ctttatccac caaagcaaga gctgttgaca tcatcatcat gcttgcatcc   1778040
agattgtcaa tcatatggat aatctctgct tccataatgc gtggacggac tgggcttcca   1778100
tactcaagca agccgtggtg actgaggatg acatgacgaa gcaaaacgac ttcttccttg   1778160
gtatcatcga tgccgagttc cataactgtc ttggtaattt cgctatcaat gagagcgata   1778220
tgtccaagaa gattacctcg cactgtgtac tctgtctggt ctggccccgt caactcgatg   1778280
accttagcta agtcatgcaa cataatcccc gcatagagca ggctcttatt gagctgagga   1778340
taaacttcgc taatagcgtc tgccaaacgc accatggtcg ccgtatgata ggccaagccc   1778400
gtttcaaagg catggtggtt ggtcttggca gctggatagg agtagaattc cttatcatac   1778460
ttggtgtaga gatttcggac aatccgttgc cagacaggat tttcaatttt gaaaatcatt   1778520
tgcgacatgt agtcacgaat ttccttgaca tcaactggtg acttgacctt gaaatcagct   1778580
gggtcattgg gttcaccagc ttgaggcagg cggagagtaa tttgattgac ttgaggggta   1778640
ttgttataaa cttctcggcg tcctttcatg tggacaacct tacctgcggt aaaggcctca   1778700
atgttatgag gttgggcatc ccagagcttc ccatcaatct cgccactatc atcttggaag   1778760
gtaaaggcta ggtagttttt cccagctcga gtttgcctca ggtcagctga tttgattagg   1778820
taaaagcctt caaataactc atcttttttc atgtgactaa tcttcatatt cttcctcatt   1778880
ttcttgaaaa tggagtagat caagcgcagg ctcaccttct gacaactcaa tgtgacggag   1778940
cgtccgctcg atagctatgg tacgacggtt taataattca tcaatattgc cagaggcatg   1779000
ttggagatgt ttttgtgcct tgaccagaat accaccaaac ttgccaaact cggtcttgac   1779060
actggcaaga gtcttgctga tatggtcggc actcttttgg atattaaggg tcttgaaacc   1779120
aactgatagg gagttaagaa gggctgatag ggtacttggt cctgcaacaa taatctgttc   1779180
ttcccgtctc aaatcatcaa agaagaccgg attgcggacg atttctgagt agagaccttc   1779240
tgtcggaaca aacaaaactc caaaattggt cgtccgaggt ggtgctatgt acttgttcct   1779300
aatatcccta gcaaagcgct tgacgcttgc taggagtgac ttacgacagc gttcaatctc   1779360
atccttgtca cctgtctcat aggcttcttc caagcggtaa taatctgcca gtggaaactt   1779420
agagtcaatt ggcagataga cgtattcttg gtcgccttgt ccgggtaact tgatggcata   1779480
ctccactcgt tcactagagt tttcaaccgt tgcgtattct cgttcgtact gggcaggtgt   1779540
catgatgtct tcaataattt gccccagttg caattctccc agaatccctc gcgtcttggt   1779600
tccagagaga accttgttaa gagctccgac atcacgggca actgtctgca tttctccaag   1779660
gccacgattg acagactcca gttgtttaga aactgtctca aaggaagcct gtaagcgtgt   1779720
ctgcaaggtc ttttctagtt tttcctcgac cgtctggcgc atttgttcca aacgttgctc   1779780
atttgattcc tgcaaggctt ggagacgttg gtctgtcttg tctctagttt ggaggagatt   1779840
atctgtcatt tcttgacgga cttgggtcag accttggtgc aattcaatcc gcacttcttg   1779900
caaacggtcg ctgacaacca cttccaaatc tttttggtct aactggctgg cttgtctggc   1779960
ttggtcaaag cggtaatcca actggtctga caaatgatct gcctgatcct ccaagctctt   1780020
acttaagtgt ttctcctgcc tatcctgcct ttgccaaatc agaaagagac cagctagatt   1780080
ggcaattaat aatagaataa gtaaactttc catcctacct cctgtccttg ctatgcagta   1780140
cgaccacata accatctggg caagttaccg acacttccct atctatatat tcgttagaag   1780200
cgtacacttt tttaaagaaa aaattttcct ctgtcaactc atacttggct ccaagaatag   1780260
tcagctggct atcccgaact ggcataaagg ctagatagtc gtagtctgaa cgaggttcta   1780320
gctgactgat tccttctgga caataagtaa tcaagttttg cccatcctca atttctattt   1780380
gatgcatata gggtgccaac ttaggattgc taggcagaaa gacattggcc aacatatggt   1780440
caatacggcc acccaaggca ccgaaaatag tgacctgagc ctgaggattt tgttcaaaga   1780500
tggttaagag agccaattcc agatctgtat catccttttc tggtcgtgct tggacaaaat   1780560
actgggcacc tttttgaatc acctgtcgct cttcttccgt cacagaatca aaatctccga   1780620
ctgctagagc aagaggtaag tcttcttcca agacccagag cgagcctcga tccaccccaa   1780680
caaaagcatc aaaatctgtc cgataatgac cgcggtttcc gcctgcaaaa actgcaaccc   1780740
tagtccagtt gttttctgag agtttgtact cgctcattga cttctccctt aaagacatag   1780800
gaacctgcta caaaaacagt cgcaccggct tctttggctt gagcaatagt ttggtcatca   1780860
atcccaccat ccacttcgat ttcaaagttc aaaccttttt cctcacgaag agcaaccaac   1780920
tcacggacct tatccatggt ttctggcaga aaggcttgcc caccaaaacc tggattaacc   1780980
gtcatgacta aaacttggtc aactagatga aggacgtgct tgatggcttc aactgatgtg   1781040
ccaggattga taacgactga aggcttaact ccgagtgaac gaattttttg gagggcgcca   1781100
tgaatatgag gcgttgcttc tacatggata ctgatgatgt ctgcacctgc acgcgcaaaa   1781160
tcttccagat gatgctcagg gtttgacacc atcaagtggc aatcgaaaac catcttacta   1781220
tgaggacgaa ggctctcgac cacacctgca ccaaaactga tttgcggtac aaaatgactg   1781280
tccatgatat cgatatgggc atattctgcc ccagttgctt ctagacgttt gatttcacgt   1781340
tcaaagttgg cataatctgc tgccagaatt gacggagcaa tcttgtattg agacataggt   1781400
ttctccttat tttggaattt ttttgctgac ttttttatag gtttctctac gattttcaat   1781460
ttcactaagg aattgcaggt aattgtcaaa acggaaggtt gcaataacac cctcttcaac   1781520
agctggtttg acggcacaag acggctcatg ggtatgggta caagtacgga acttacaatc   1781580
tcggctaaca gtagcaatct ctgggaaagc ctgattgagg tcttcagccc ttgatacttc   1781640
atagtccaag gatgaaaatc ctggtgtatc tgcgatttta cccccgttga gattgtaaaa   1781700
actaacagct cgagtggtat ggcgaccgcg acctagactg tctgaaattt ctcccgtttc   1781760
aagattgagg tctggtgcga ttttattgag aagagttgac ttcccaacac ctgtctgccc   1781820
cataaagacc gtaaccttgc ctgttaacaa agacaggagt tcctctttac tggtcacaaa   1781880
gtcatagccg atgtcaccat aggtctgctg gtaaaaatcc agttctcccc tatcttccaa   1781940
caaatccatt ttggaaatat agacaatggg atggatgccc ttgtgctcca aaagaaccaa   1782000
gaaacgatcc agcaaattgc tgttaaaatc aggttccttg acggacatga ttactacagc   1782060
ttgatcgata ttgacaatag gcggacgaac cagactgttt ttccgttcgt gaattttgag   1782120
gatatagcct tctgaatttt cctcggcaga gaaatctacc cagtccccaa cataaggggt   1782180
atggcctttt ttacggaaat tcccacgcgc gcgtgtttga taaacctggc catcactctc   1782240
cacatagtag aaacctgcca aggctttaat gatttgtccc tgcatcttag agtccttgcc   1782300
ctttaagtgc gtctgctaga ccggcaaatt ctgccaagct gagagcttcc ccacgcacac   1782360
ttggtgacaa gcctgcctgg tccaaagcct tggtcagctt gtccttgacc tcttcagtct   1782420
taccaaagta acctgtcaag ttattccaca aggtcttgcg gcgatgggta aaactagcct   1782480
tggaaacctt aaagaaaaag ttctcatctt ctactgctac ggctggctct ggacgacgca   1782540
ccattttcaa gatggctgaa tccacatttg gcgctggcac aaagaccgta cgaggcacga   1782600
taaaggcaac cttggctgtc atgtaatact gcacggcgat agacaagcta ccgtaagcct   1782660
tggtgttagg ctgggctgaa atgcggtccg ctacttcttt ctgcatcatg accacaaact   1782720
cacaaaaagg aatgccactc tcaatcaagt gcatgagaat aggcgtcgtg atgtagtaag   1782780
gcaaattagc cactaccttg attggcaggt caggattttt aaaattctgg atatgttgcg   1782840
ccaaatcaac cttgagaata tcttcgttaa ctacggtcac attatcaaaa tcacgcaggg   1782900
tatctgccaa aattggcacc aaacggtggt caatctcaaa agccatgact tgggctgcac   1782960
gctcagccaa aaattctgtc aaggcaccaa tacctggccc gatttcgatg acattgacct   1783020
gatcatcaat ttcagccgta tccacaattt tttgaaggat attggtatcc gtcaaaaaat   1783080
tttgcccaaa ggacttttta aaggtaaaac cgtgacgctc cagcactgcc ttggtcacgc   1783140
tataatctgc aattctcatc tattctcttt tctattatct gttactacta ttgtaacaca   1783200
ttccccttgt attttgggaa tgaaaatcat accaaaaaac tatctttcct catgaagaaa   1783260
gatagtcttg gaaatcttta aaagtggcct tagcagttct ctcgaaacat gcgttcaaaa   1783320
aaatcagctt cttgataact tcgattttca ggtagggtca aatccacatc ctcctccaca   1783380
tcatccactg tcagttcaac cgtctgaggt aaatttttca aacgataatg cttttgcctt   1783440
tgcccttcaa tactagcaaa atcaagcaaa tagccatgca ctcggatttg aaccaaaagg   1783500
agatgattgg tcatattttc catgatgagg atatcttcta aaccacctct ggcactagga   1783560
taatcagata ccctgcgaat acggattttt tcacacatga gcaagtttcc tcatatcaat   1783620
gatttcatca gccttattcc agactagggg attatgggtc gcaatgatga taattcgatt   1783680
ttcatctttc aaatccacca agagattcat aacctcctct gaattttcag gatcaagagc   1783740
tgctgttggt tcatctgcca aaatcaaggg tggatttttc aaaatagtct tagcaagggc   1783800
aactcgttgg gcctctcccc cagataaagt atagattttt tgttctaaat ccaaataccc   1783860
tagattaact ttttctaaag cccccacttg cctttccaaa cgttctactt ttgagatttt   1783920
ctgaccaaca aaacccaaat ccaaattttc tttgattgat tggttttcta agaggccgaa   1783980
attttgaaag agatagccca tctggtctcg aaaatactca cgagtgggaa tggtttttaa   1784040
atctttcccc tgatagagaa cccttccacc atctatcttt tctagctttc ccaagatatt   1784100
cagcagcgtc gtctttccgc ttccactctt tccgattaag gcataaacct tgcccttctc   1784160
cagcttgaga ttcaaaccag agaaaatcgc gcggtcatta aatttctttt ccaatccttg   1784220
aatatcaatc atcttatttt cctttcaata ctgccatgct accagcttct tcttttttgt   1784280
cctgccttac taaaatcaag agggcgttaa gcgtaaacaa agctacaact agagcgctaa   1784340
tcaaaccatc tcttgtcaaa atactagata ggactaggcc aagcaagaga actcctcctt   1784400
gcgccagtaa atacttgcca tgaagctcat agattgtcat accagcaaga cgtttaatca   1784460
taagttcccg tctgaactgc tcaaaataga gaagattcat ggaatcaaat aacaagatag   1784520
ccgtagacag ggtcaaaatc gtcccaataa ggagagagta aaactccacc cgtttgtcat   1784580
ttagtacctt ggcaaaaaat agctggcttt ttaccaagta agaaaccttg tgatacagac   1784640
ctttctcttt tagagctgtg atgctgtctc catatcgatc tagtttcaag gcactattag   1784700
ccgtagttcc ccacaacatc cctgcaacag gtcttgttcc agtcgcttgc ggcgttagaa   1784760
ctacaataat cggatctttt aggtactggc gtgttgtctt gtacccatca ttatagagga   1784820
aacgttcctg tcctgtttct gtaaaagcta gccttacctg tgggaggtag tgtttctgac   1784880
tcgtcacttc tacactttca gatgaaaagt tttgcaggta atctgtaaac aatccttggt   1784940
agtagacaga ctgctctcgc aagctctcag gcaagatcag cccaaactct ccctcagaca   1785000
agttttgcat cttgtccata aactctgaag aaacggtaat cttttcttct atcagatagc   1785060
gcggtgagac atagataaca ttccctgacg gtgtgtagtc actgagacga ttgccatcta   1785120
ggtccacttc tgctccatct gagaaattgt caacattgct cataatataa aaagagtctg   1785180
tattggctaa ccgttcttca gtaaatgtct gccactcacg attatcctta cgcgttcctt   1785240
cttcatcggc aaatgcacta gaccaaccaa aggatagacg gtaacggtct gaggactggc   1785300
tccatttatt gctagctctc tccatttcct gcatttcacg gtagtggggt aggagagctg   1785360
tcgcactcga tccgaccacc aatacagcta agagttgccc caccatcatc aatgtcatca   1785420
tacgtttgag agggagtttc cctttcaata gatccaccag actattttcc tgtaaaccaa   1785480
gtagatagac gacacttagt aaggtagaaa tccctgccaa ggtcaatcca taaagtagaa   1785540
gagcaatgat gaccagttgc accgttgcca taaacaaggc accttgatac cagagaatcc   1785600
ccaatcccaa aagactggat accagcactg agcagataag ctgtctcaca tcttctaaca   1785660
ctggtctgag agcaactcca aacaagctct caccagctat taagcgaatc cctgcctgac   1785720
gaagggattt gatccgataa atcagggtca gactcataaa ggtcagcaga aaaatagcta   1785780
aactcagtag caccataggg gtggccgtca atagtaagac tatcgaaaat ggatcttctc   1785840
cattcgaaac aaagccttga taaccaagct ctttcaaggt ggtctgtaag ctcactccat   1785900
ccaaacttcc tgatacaatc aagtaagacc ctaataaatc actcgtttct gcactctcct   1785960
tggaggaaat ggtcagacct tctggaagct ttccctcacc ataagtggca taggtaaagc   1786020
gtgtttctcc agcttcattt ggctcaacga ttcgacgagc aatgagacta ttgtgctcta   1786080
ccgccaagtg actcaaagcc tctgtcacct cttcgcgact agctactggt tgatttatca   1786140
tcattcctgt cacatcaaca gaaggatagt taccaaataa aatctcttct cgatggtcaa   1786200
cggaagttat caccatataa agcgatacta ataccattga aatcaaaata aataaacgtt   1786260
tcatcatttc ctccaaaaag ttacttggtc acttcgtgag aaggtgacca cagtcactgc   1786320
gatgttaaga agcttattaa gttctttctg ctagcaacat cttcaaatac attatatccg   1786380
ttttttcaag aactatcaag gacatcaatg tccttaaaat ctaaccattt cgtgtcattt   1786440
ttagcttata tctaaaaaaa catccctaaa gacgaacttt agaactgttt tgatacgagg   1786500
acaaggacat ctttgtcact gattcactat gtttataaat attttttgac atcctcttgc   1786560
cattcctctg tcaatttctt tactagaaat tcatctccaa ttagctgcgc aaatgtttta   1786620
gaagactgat aaaatgattc agctaaacta aaatctcttt cttctcttaa tgcttgcttc   1786680
cacaaaaaca taaatacaag aggtttcttt tgataatctt gagttttatc cataatttct   1786740
tgtaaacacg atagataatc attaaaacaa tcagttactc ctaccttttc aagacaacac   1786800
attcctgaaa taagagtatc tctaattata aagtaattct ctatttgagt taccttcttc   1786860
tgttccaaaa gaaagagcat tagcttttcg atttgattta taaatttggc aagatctttt   1786920
ctaatgagca tttgataaaa aaacaaacga atcaacaaca tatcatttat tgaataagct   1786980
tctttttcta taatctgagg catatgttcc tcaagtatta actctgcata ttcaggcctt   1787040
ctagttctag aagtatccaa acacgcctgc aatacttcac atgctaattg ttcttcttta   1787100
ggaagattat caaagtatgt tttataaatc tcttccaaac acgcttcctt cttatcgtac   1787160
tcctcttctt taccatagat tggttcacgt aaaatctggt atttcaattc taaataagca   1787220
gaaggaagag ctgaaaaatc cggcataagg ctataaactg gaactcctag ccggcgagca   1787280
atatagtcta acttgggcaa actcggttgc gaagctccac tttcaattcg cgacagttga   1787340
cgaactgtca gttcttgctc atctccacaa aaatctggac gactaattcc tttttctatc   1787400
cgaatctctt taattttttg accaattaac atcagacgcc tcctcttcta cctgcttcga   1787460
aaaatactgt gaaacttaaa aaattgtaac ggctacatct ttcctactca taagatttca   1787520
tagcttcttc cacttctgcc aaagtaaccc caaacaactc taggcgtttg aggagttgct   1787580
tgccgttgga atagccgatt cggagagtct ctccgagata ttctctacgc ttacggctgt   1787640
ctgcccctgc tagaaaacca aggcgaatca aatcgctacg actaatgtca aactgactct   1787700
catgttcaaa ttgttctgtc acttgagcta gagccgtttt caggtcttca tagctggcat   1787760
gctcaattcc cagagaacgc cccttggtct tggacttggg aacagcttca tctcgcttga   1787820
gaaaggcatg ctgaactgtt ggaatgacca tcatgatcat gcgccgaatc cgttccccat   1787880
taaaatctgg gtctgtaaag acaatgactc catgacgttg gtgcaggcgc tgaatccgct   1787940
ctatatcctg agcattgatg gcagaacctc gagtctcata ggtctccaca tcgaaataac   1788000
gtttgagatt gaccgtatca tcacgccctt caaccacgat aacttgagaa attttctctt   1788060
tcattacttg ctgtccagtc caaaaattcg ttctgcattt gcagtcgttg ctaccgccag   1788120
ctcttctgtc gtcataccac gcaagtcagc gataaagtcg accacatagc gagtataggc   1788180
tgttttattt tcacgaccac gcttgggtac aggtgctaag taaggcgcat ctgtttccac   1788240
caacatcttg tccaaaggta actctttagc tgcttcttgg aggtcagttg ccttcttaaa   1788300
agtcaccact cctgagaagg aaatggtcat accaagatcc acaaacttct ctgcccactc   1788360
aagcgtccct gaaaatgaat gcatgatacc accacgagga ccaacgccct cactcttgat   1788420
aatctcatag gtatcttcca gcgcatcacg ggtatggaca acaaaaggca aatccaagtc   1788480
cttagatagc tgaatctgac ggcgaaaaac ctgctcctgc acctctttgg gcgctgtcat   1788540
ccaatggtaa tctaagccaa tttcacctaa agccacaacc ttggaatgtt ttaacttatc   1788600
caacaagtaa gcctcaactt cctctgtata agtaccagct tctgtaggat gccaaccaat   1788660
agtcgcatag agctgctcat actcatctac caactccaag gcatgctcaa tcgtcggttt   1788720
atcaaaacca acaatattca tctgtgtcac acccatctca gcagccaagg caatttcttc   1788780
tgcctcacga cctgcaaatt cttctacatt caagtgtgta tgtgtatcaa aaatcatctc   1788840
ttctaacctc gttttctatc ttctattata ccaaaaaaga ggaggggcac ctaatttttc   1788900
ggtttcccct cctctcttca atagagagct attctgctat cttttctatc cgatattgcc   1788960
catctcctat tccacagtta gagacagaag agattggcta cattgataga atattcctat   1789020
tcagctaaag tatgtgatta tcttgggttc tcacttttct cacccatcac taggattgat   1789080
gacttctcaa aatccccctt ataatctaac tttaagtaga gaatagaatt ttctagctgt   1789140
tctattttct acgtctagtc tttcttccta gcaaagcaaa accacttgtt gccaccacta   1789200
gaccaagact agcaagtgct gcacttgatg ctgaacctgt gttaggtaat tgtttgccag   1789260
caggtgactg gtaggtaaca tcttgcattg ttcctgcagt tgcttgcggt gcacttgttg   1789320
tcttaggagc agcattagga gccactggtc tcttaggaac tgtaaccatg gcaatggctt   1789380
gcactccaat cgtttctgct tccttcacat cttccatagt tttcgcattt tcaatctctt   1789440
tgagagctgc ttgtttttct gcttccactc ttgctaaaag ttctgctttt tctttatcag   1789500
aaagcggtgc gcctttgatt tcatcctgct tgtccttggc tgctttttca atggcatttt   1789560
tagctgattc tttttcagta gctaattgct tagaagcttg tgattgagct gagttttgtg   1789620
aacctgtgtg agctgatcca cccgcctggc taccaccgcc ttcattcgca ttagcatctg   1789680
agcttccagt attgcctccc ttatctccac ctggtgtatt ttctagctta tactctggtg   1789740
tagcttcttg agttacagat tcacctttcg cagattgttg aactgtatct tttcctagaa   1789800
tcgtcactac tgaaccatct gggaatgtga ttgttgctgt accatctcca gctacattga   1789860
ttgtcgctcc gtctaatgct gaaccatttg cttgtaaaat agcaacctta actttttctt   1789920
catctgttaa atgagttata tcttttacat ctactctttg agcaggtgct ttaacagttg   1789980
atttttcagc agtcagttta gtgctatctt gtgcttttgg atcttgtgct accaattgat   1790040
ttcctggaat tgtaatagct gaaccatctt taaagacgat tgttgctgta ccatctccac   1790100
ctacttcaac tttatagtaa aataaaataa taacaggaca aatcgatcag gacagtcaaa   1790160
tcgatttcta acaatgtttt agaaacagag gtgtactatt ctagtttcaa tctactgtaa   1790220
catcgcttcc gaatccattt gcatctactg aactttttta caaaaataaa aatcagtaga   1790280
ctcgagttcc tactgatttt tgatagaatt cgtttggatt atgcagccaa aactttgcgt   1790340
cctttacgac gacgagctgc caatacgcga cgaccatttt tagttgacat acggttacgg   1790400
aatccgtgtt tgcgcgcacg acgaagttta cttggttgat aagtacgttt cacgatgaat   1790460
acctcctcat agattttgta ttcgtttagc cggctataaa gtgatcagtt actaaacata   1790520
ctttactatt ctatctgatt ctttcacttt tgtcaatagc tctaggcaaa tgtttccagc   1790580
tttttcgaat gcaagcccta tctacgatac tgtttcaaga aacgagtcat cttttcttgg   1790640
atttgggcta actcatcaac acgaggaagg taaacgatac ggaagtggtc tggttcctgc   1790700
cagttaaagc ctcgaccatg aaccaagaga accttttcct gcttcaagaa atcaaggaca   1790760
aactgctcat catcatcgat acggtacata ttgcggtcga tttttgggaa gatatagagc   1790820
cccgccttgg gtttaacggc agacaaacct ggaatatctt gaatggcatt atagatgaaa   1790880
tttctttgct cgtagattcg tccaccagga agaagcaatt catcgactga ttggtgaccc   1790940
cccaaggaag tttgtacgac ttgttgggcc aaaacgttag agcaaaggcg catattggac   1791000
agcatattga gcccttcgat atagccctta acatgagtct tagggccaga caagaccatc   1791060
caacccacac ggaaacctgc tatgcggtgg gattttgaca gaccattcat gctgacacag   1791120
aagacatctg gtgccaagct cgccacaggc gtatgcacat gtccgtccat taccatgcgg   1791180
tcatagattt catccgcaaa gataatcaaa tcgttttgac gggcaatctc aataatctcc   1791240
agcaagagtt ccttaggata aagggctcca gttgggttat ttggattgat aaggacaatt   1791300
gccttggtat tggaagtgat ttttgacttg atatcgtcaa tatctgggta ccattccaca   1791360
gcttcatcac agatatagtg aacggcattt cctccagcta ggctgacagc cgccgtccat   1791420
agaggatagt ctggcattgg cactaagacc tcatccccat tgtccaaaag cccctgcatg   1791480
gacatgacaa tcaactcact gacaccattt ccaaggtaaa tatcatcagt atctacgttt   1791540
gggaatttct tcagctggca atactgcatg atggccttac gggctgagaa aatccctttg   1791600
gagtcagaat agccttcact atcacgcgca ttcataatca agtcatgaat gacctcgtct   1791660
ggcgctgtaa agccaaattc tgctggattt cctgtattca gacgtaaaat cttttctcca   1791720
ttcgctcgca tccgcatggc ttcttccaat acaggaccac ggatatcata agcaacatgc   1791780
tctaacttac tagacttgtt atattctttc atcttgtttc ctcaattcat caggatagta   1791840
acattatacc actagaaaga gaatgcgaca agtttactga aatgtgttac tagtttcgta   1791900
tagaagaaaa accttgctaa aggcgaggtt aagaacgtag agatagcagg tattttgcaa   1791960
agacacatca cataccaaaa gataaaccta gaaaaaagca agcctagaaa ggagtcataa   1792020
agaagattaa acatgaggaa aagcccccat atcatcaagt aatcccaacg cccacttcgt   1792080
tttgcaacta gaaataagat tagatggtag agtacatgaa aaactaaaaa tccaataaaa   1792140
cttggataaa gaagcggtac cagactctct aattgacaga tcatgatcac ttctaccaag   1792200
actgaaacta ggataattcc ataataaagg aaatttgatt tttgaaaaga gtttttcatc   1792260
attctccctt ccttcacttc tttcctgcta tcctttcttt tattttatca tatatttata   1792320
tagagtttaa gccctaatat tcttttgaaa aatacttttt ttgctttact tctatagtga   1792380
aaaggtttac aattatagta agaaaatttc aggaggtttc attatggcac aacgttacca   1792440
aaatatcatg gtcgcaatcg atggttctaa ggaagcggac ttggcttttg tcaagggagt   1792500
tcattctgct ctacgaaacg acgctaaact caccatcgca catgtcattg acacacgcgc   1792560
tctccaaagc gtatccacct ttgatgctga agtttacgaa gaactccaag tcgacgctga   1792620
aagtctgatg aaagagtacg aaaaacgtgc taaagatgct ggggtagcag atgttcatat   1792680
cgtcattgaa atgggaaatc caaagaccct gctagcacgt actattccag atgccgagga   1792740
agtggacctc atcctcgttg gcgcaactgg tctcaacgcc tttgaacgcc tcttggtcgg   1792800
ctcttcatct gaatacatac tccgccatgc taaggtcgat ttgctggttg tgagagaaca   1792860
agaaaaaacc ttataatcac aaagaaaagg agcccctagc tcctttttgt ttacgattta   1792920
tttctctctt tatggcgttc gtaagccttg agctggcgct gcagttcctt tttaatagca   1792980
ggttctggag catatttttc ttcccaatta tctggtttta agattttatg ggtcactgga   1793040
tcaaaatgag ccttgccatc tggaaaaatt ttccccatat tggcctgatg gacaatatca   1793100
aaaatacgtt ctgggtccac ccccatcaag acaaaactgc cgtaggtgaa gtaaagcgtg   1793160
tcaatcaagg catccacttg ccctatcaaa tcttgctgag caggtgtctt cttggctact   1793220
ttatctgctg ccttatcaag ggcctgatga agttgcgata cagcttgacc aaaatcttct   1793280
tcagaaggac tggctgctcg aacaaactcc accaattctt ctattttaaa accagcccta   1793340
tgggttgcac cctctaaatc ccaagctcga ggttcttctt gggttcgttc atccatcatg   1793400
tggtggaagg tcttgacctt attgaaatga tagtcacggc tgacaaagac tttttctgaa   1793460
gacaaaacac caaaatgttc caaggccttg tggattccat cttgttgatt gctagtggta   1793520
atgtgcttgg cagcttcctt gacactgcta ctaccatttc ccatagcgac cgacatacca   1793580
acgccagcca gcatttcaag atcattatct gagtcaccaa aagccatgac ttggttgagg   1793640
tcaaagccat attctttccc aactcggcga atgccttcta atttagaatt tccctgattg   1793700
atgacatccg atgcaaaagg attgctacgt gtcaatttca agtcttcaaa atcagctgcc   1793760
gccttctcag attcttctgg tgtcatcagc atcaaaactt ggtagatagg ctgattcatc   1793820
aggtgaagca ggtcctcttc cttttgggga acaaccttgc tgaccatgcg attaaaagac   1793880
tgactcaccg tccgagttaa aacagaggga acgaagcgac taattcgttg ggaaaaagaa   1793940
cccagaccaa aggacatgat tttagaaccc aacatggcat ccttggtccc tagagcaatc   1794000
tccgtgccct cttttttagc atagctaatt agatggcgca aatgtaactt ggaaataggg   1794060
ctcgtgaaca agactctgtc tttactaaag atatactggc cattataggt taccgcaaaa   1794120
tccagatcca aatcgtccat caattcctta acaaaaaaag gtcctcgccc tgtcgctacg   1794180
ccaactagta ccccttgttc tttgacaatc ttaatcgcat ccttagtgga tttcaaaaca   1794240
ctcttgcgat tgttgaccaa ggttccatcg atatcaaaaa aaacagcttt gacttccatc   1794300
ctatcccaat ctcccctttt gtgatacaat gattatacca catttcagaa agagtgagta   1794360
aatcatgcct aagaaaatcc ttgttttaca tacgggtgga actatttcca tgcaggccga   1794420
tgcttctggc gctgttgtga cgagttcaga taatcccatg aaccatgtgt ccaacccact   1794480
tgaaggaatc caagtccacg ccttggactt ttttaacctt ccaagtcccc atatcaaacc   1794540
caaacatatg ctggtcctct accagaaaat taaagaggaa gcagataact acgatggagt   1794600
ggtgatcaca cacggaaccg atactttaga ggaaacagcc tatttccttg ataccatgga   1794660
agttccccat atgcctatcg ttctaacagg agccatgcgt agctccaatg agctcggtag   1794720
tgatggtgtt tataattacc taagtgcttt acgagtggcc agcgatgaca gggctgctga   1794780
caaaggagtt ttggtcgtta tgaacgatga aatccacgct gccaagtatg tcaccaaaac   1794840
acatacgact aatgtcagca ccttccagac tccaacacat ggcccccttg gtctcatcat   1794900
gaaacaggaa atcctctact tcaaaacagc tgaacctcgt gttcgctttg accttgatca   1794960
catacaaggt ttagtcccta tcatctcggc ttatgctggt atgacagatg agctgattga   1795020
tatgctggat ttagaacact tggacggttt gattatccaa gccttcggag ctggtaatat   1795080
tcccaaagaa acggctcaaa aattagaaag ccttctgcaa aaaggaattc cagtcgctct   1795140
ggtatcacga tgctttaacg gtattgccga gcctgtttat gcataccagg gtgggggcgt   1795200
acagttgcaa aaagcaggcg ttttctttgt taaagaactc aacgcccaaa aagctcgctt   1795260
gaaactcctc atcgccctca atgccggact aacaggacag gctttgaaag actatatgga   1795320
aggctaatac tcttcgaaaa tctctgcaaa ccacgtcacg tcgccttacc gtatgtatgg   1795380
ttactgactt cgtcagtttc atctacaacc tcaaaaacat gttttgagct gacttcgtca   1795440
gttctatcta caacctcaaa aacatgtttt gagctgactt cgtcagttct atctacaacc   1795500
tcaaaaacat gttttgagct gacttcgtca gttctatcta caacctcaaa aacatgtttt   1795560
gagctgactt cgtcagttct atctacaacc tcaaaaacat gttttgagct gacttcgtca   1795620
gttctatcta caacctcaaa aacatgtttt gagctgactt cgtcagttct atctacaacc   1795680
tcaaaaacat gttttgagct gacttcgtta gtttcatcta caacctcaaa aacatgtttt   1795740
gagctgactt cgttagtttc atctacaacc tcaaaaacat gttttgagct gacttcgtca   1795800
gttctatctg caacctcaaa gcagtgcttt gagctgactt cgtcagttct atctacaacc   1795860
tcaaaacagt gtgttgcgca gcctttaatc agccgcctag tccgctctat ggtattcatt   1795920
aagtcaacat ctcttgttta agagcaccaa atcaggaaat cttctcgatt ccctgatttt   1795980
ttctatttac gttttcgtgt tgagctacgt tctgtcaaac catgaggtaa gagaacttca   1796040
cgttcttcca actcttcctt atgcataatc ttggtcaaca tacgcatact aatggcacca   1796100
aggtcataaa gaggttgggc aatcgttgtc aagtttggac gggtaaagcg tgagatttgt   1796160
gaatcatcac tagtaataat ttcaaaatct tctggcacag aaacaccctt atcagccaaa   1796220
ccgttcaaga ctcctgctgc caactcatca cctgtcacaa ctgctgcagt tgcatttgat   1796280
gaaatcaaac gctctgctaa ggcgtaacca tcatcatagc tatatttaga ttcaaatacc   1796340
aaaccctcac tataagtgat tcctgctttt ttcaaggttt ccttgtagcc aactaaacga   1796400
accttaccat tgatgtcatc cactagcgga ccgctaacga aagcaatacg ctcattttct   1796460
ttagcaaggt aactcactgc atcaattgtt gcttgcttat agtcaatatt gacacttggc   1796520
aactggtgct caacatcgac agttcctgcg agaacaatcg gagtacgtga acgcgaaaat   1796580
tctgagcgaa ttttatctgt caagtgatac cccatataga taatgccatc tacctgcttt   1796640
gaaaagaggg tattgacaac agaaacttct ttctcgttat cttcatcgct attagctagg   1796700
acaatattgt acttgtacat ttctgcaata tcatcaatcc ccttagccaa actcgaaaaa   1796760
taaccattgg taatatttgg aatcacgaca ccgacagtgg ttgtcttttt acttgcaaga   1796820
ccacgcgcaa ctgcatttgg acgataatcc aaacgatcaa ttacctctag cactttttta   1796880
cgggtattct cttttacatt tttattgcca ttgaccacac ggctgaccgt cgccatggaa   1796940
acacctgctt cacgagcgac atcataaatg gttactgtat catctgcatt cattcctttt   1797000
cctgtccttt ctatctcaca cattctttta caagtagagg tactgattga agctctatat   1797060
ctacttacaa aagtgaagat gtgaaaattt cgttttcata tttctactta ttccattcta   1797120
tcactaattg taaacacttt caagtgtttt ttgaagattg attgaaaaaa tttcatagaa   1797180
aacctaggtt tagctccttg ctaccacctt agactaaaca aaaaggagga aactaagccc   1797240
tcctaaagtt atagtaaaat gaaataagaa caggataaat cgatcaggac agtcaaatcg   1797300
atttctaaca atgttttaga agtagaggtg tactattcta gtttcaatct actataggta   1797360
ttgttccatt cactaccgtc aattttagca catagtcttc atgaaaatat tatatcatca   1797420
taaccaacca gattctttcg cgatattagc tgcctctgtt cgattacctg catctagttt   1797480
cgaaagaata ttggtgacat agtttcggac tgttccgttg gatagataaa gtttgtctgc   1797540
aatttcttgg ttagagaagc cctgagcaat tccctttaaa actgcgattt cttgctccgt   1797600
taatggattg ggatgcatca tcaccacttc catcaattca ggcgaatact ccttgcgtcc   1797660
ttcgaggacg gtgtgcaagg tttgcatgag gtctgcaatg tttctttctt ttaatacata   1797720
agcatctact ccagccttga ccgcacgttc aaaataccca ggacgcttga aggtcgtcac   1797780
cacaaccacc tttgtttcaa gcttttctgc tcgtatccac tccaagactt caagacctgt   1797840
cttaacaggc atttctacgt caaggatggc gatatctaca gactcctttt ctaatagttg   1797900
gattgcttct tgcccattct tggcttgaaa gacagactct acatccggtt gaagcatgag   1797960
caactggcac atggcatctc gcaacatact ttgatcttct gcgactaata ctttcatcta   1798020
ctttctctcc ttataaagta gtcgaacctg cacttcagtt ggatgtttct gactgattac   1798080
acttacttct cctgaaaatg gaaaaacacg atttcggact gtatggagct catccccgct   1798140
tatagaggca aagccacagc catcatctct cactgttaga atgagttctt tctctgtccg   1798200
ttctaatttc aagtagactt tagacgcttt agcatgtttg atgatattgg tcactaattc   1798260
aagcaaaatc atggaagccg ttgactccaa ttcctgagtt aagctagact tgtccaagtg   1798320
attctcaact tgaacctcaa ttccagcaat ttctaacatc tttttcacag tctctagttc   1798380
ggatgtcaaa gttctagact taagattttc cacaatggtt cgcacttcat tcatggaatc   1798440
cttgctgatc tggtgaattt cttttaattc cttttccacc tgtggataag cctccatctg   1798500
aaataactgc aaggctaaat ctgtcttgac actcagcata gcaaaggtat gtcccagact   1798560
atcatgcaaa tcctgaccga tacgactacg ttcattttca gcaagcaata gatttatctg   1798620
agcattttgc ttgacctgag cttctttcaa atcctcgaca atacgaatcc gaaccaatcc   1798680
aaaagtcatt aaatcgacaa aagtaagaat tacaagtaga tagaatagaa actcaacttc   1798740
gattctctga aaaatcaaca gttgccccac aacaaggact tgagcaagaa gaaaagtcca   1798800
gacatgtaaa gactttaaac tacgtacgct gaaatgataa cttaagagat tggataggaa   1798860
aaagaaaaac cagatataat taacagcaac aaaggcagta ttcccaacta cataagtcag   1798920
catgaggccc caatatagcc aagataggcg ctggctctta gttgttaaaa cacccaaata   1798980
tgccactaca aatagaatat caatcaataa atgccaggca gaaagccacc cagtcactac   1799040
agacaggatg gggaaaatca taaaaattaa actgatccaa aacatataat gtattctttt   1799100
cagtctttca agcattaagc attctcctta tgaccttgaa ggtaaatggt caaaccaaac   1799160
aaaactactg aaaaaacaag taaataaact gtggctgata gattgatgcc accctcattt   1799220
aagaaggtct tgagcaactc catcaactga taggtcggga gacacttacc tactacttgc   1799280
atccagtctg gaaataaaga gataggcatc cagagtccac ctaaaacagc caaccctaga   1799340
taaagaagat tgcccacgac agacatcaac tgactagttg gtaagagagt caaggtcaaa   1799400
ccaagcgcta cgaaggcaat acttcctact atcagcaaaa gtgcagcccc aatccaattt   1799460
ccaagagaca tgtccacacc tcttacaaaa tgcccaactg agaaaaccac caagattgaa   1799520
accaaataat caaccagcat acttgttatc tttgatagat aatattctac catatttaca   1799580
gggctatgac gcaatgtttt ctgccagttg ttgatcttgt cggtatgtaa aacaactggg   1799640
aatgagaaga tagctgttga catcatggaa aatgcagtca tggagataag ataatcacgc   1799700
ataaaattcg cgagttcacc tggtgtgtcc tgatagatac cagaaaaaaa taaatagaaa   1799760
gccgtcggca tccctactga caatagataa tagatcaatt gtcgtttggt caataaaaat   1799820
tctatcttac taagtgctag ccatcgtttc atcttagtta tctcccttct gcgtttcttc   1799880
aaagattgta tccaacaaac tacgattatt aacttcaatt tcttgtatgc cacatcctgc   1799940
ttgaactaac agttcccaaa aagcatctgc ttcgcgtgtg actacttgta gagcatcctg   1800000
tttttgtgac cagttttcaa ccaagttaga ctgctcaatg acttccttgt atgccagagg   1800060
aaggataaaa tgcttttcaa ttccctcact acgcatagct agaggcgtcg tatcacgaat   1800120
caactctccc ttatttaaaa ccaaaatccg gtcagccgta tgctctacct cttcaatata   1800180
atgagacgaa tagagaatcg tgactccttg cgcttttagg tcccgaacga tttcccaaaa   1800240
gcgttgacga gttgaagtat ccatggcagc agttggttca tctaaaaaga caagctttgg   1800300
tcgcccaatc aaggtcaaga caaaagagaa gagacgcttt tgcccgcctg acaatttttc   1800360
tgcgaattgc tctttttgtt gctggtcaaa ctgcaatagt tgatcgattt cctgatcgct   1800420
caaggaattt ggatagatac gttgaaagaa agcaatcaac tctttgacct ttaatttctg   1800480
aacgatgaca ttttcttgag gcagataacc tctaatatag tctaactgag aactcgtcac   1800540
tgacaagcct tggatggata cttgaccgct tgtgaccagt ttatctccaa gcagacagtc   1800600
caagagtgtg gtcttcccag caccattggg cccaatcaag gcgacgcatt caccttcagc   1800660
tacctcaaag gaaataccct tcaaaatagc cttgcccttg atgtttttat ttaggctttc   1800720
taccttaatc atattcatga tattctcctt tcaaccactc cattctcata aggaaaacga   1800780
cgaaaatcat aaatccaaac cccaaagcac cacgaatgaa ttggcgaagc aaggtttggt   1800840
caaaccaacc tgtaaacatt tccactaacc ataccaagag tgacaggccg ataaagaaat   1800900
agatgatccc tctcttcatt cctcaagctc ctttttcaca tctccgacta atttcaaacc   1800960
ttctctaaca agccaagaca tcattccaaa gccagcaaag agctcccaag gaaaatgata   1801020
gaaactctca tccaatcccg aaaacatgag ttaggtcata actcctgcta ctactaaact   1801080
cactgcgata atcattttat ttctcatctc ttcttcctcc atttcatact acaattatag   1801140
tcttttgaaa tcagaggaga cagaagcttc tgtcactaga aaatatgaca aatgtcataa   1801200
aaaattctgt tcaaaacaag caagatacac tatacaataa aacacaatta gaaaaatcta   1801260
aggcaacttc ctcaaaagag atatcaaacc caattcacac cataatgtaa actaatactt   1801320
atttaaaatc aaaaagagta gaaattttta tcagacaaac acatatatag tgtattgaat   1801380
ctataacagt aggccttaaa tactaaaata tttctataaa ttaatttaac tttcctgata   1801440
gagctgttca tatcttattt caattctcta aattatacgt tgaacaaaac ccttctattt   1801500
ctttcttaaa gatttataag agttataaaa tctgttaaat ttcaatgtgt atacctaaac   1801560
tacggtattt attgaaaaga ctggagacaa aaagtatacg ctgccaaaat gaattactga   1801620
aaatcaaaaa agagagaacc aaactgattc cctcttaatg tatataatat ctagttttaa   1801680
aaatacacac tcacatatct ctgtaatgaa tcgggaagac aggattcgaa cctgcgacac   1801740
cttggtccca aaccaagcac tctaccaagc tgagctactt cccgagttaa atagaaaaat   1801800
gcaccctaga ggagtcgaac ctctaaccgc ctgattcgta gtcaggtact ctatccagtt   1801860
gagctaaggg tgctccatat tatgccgagg accggaatcg aaccggtacg atcgttacca   1801920
atcgcaggat tttaagtcct gtgcgtctgc cagttccgcc accccggcct ctctaagcga   1801980
acgacgggat tcgaacccgc gacccccacc ttggcaaggt ggtgttctac cactgaacta   1802040
cgttcgcact gttttcttct atctaaaaat gccggctaca tgacttgaac acgcgaccct   1802100
ctgattacaa atcagatgct ctaccaactg agctaagccg gctcatttgt tatatcttaa   1802160
tgcgggttaa gggacttgaa cccccacgcc gttaagcgcc agatcctaaa tctggtgcgt   1802220
ctgccaattc cgccaaaccc gcatatatga cccgtactgg gctcgaacca gtgacccatt   1802280
gattaaaagt caattgctct accaactgag ctaacgagtc taaaataact tgcgttacct   1802340
taaacggtcc cgacgggaat cgaacccgcg atcttcgccg tgacagggcg acgtgataac   1802400
cgctacacta cgggaccttt gggagttaac gggatcgaac cgctgaccct ctgcttgtaa   1802460
ggcagatgct ctcccagctg agctaaactc cctagagcta agcgacttcc ctatctcaca   1802520
gggggcaacc cccaactact tccggcgttc tagggcttaa cttctgtgtt cggcatgggt   1802580
acaggtgtat ctcctaggct atcgtcactt aactctgagt aatacctact caaaattgaa   1802640
tatctattca atttaagaaa accgttcgct ttcatattct cagttacttt ggataagtcc   1802700
tcgagctatt agtattagtc cgctacatgt gtcgccacac ttccacttct aacctatcta   1802760
cctgatcatc tctcagggct cttactgata tataatcatg ggaaatctca tcttgaggtg   1802820
ggtttcacac ttagatgctt tcagcgttta tcccttccct acatagctac ccagcgatgc   1802880
ctttggcaag acaactggta caccagcggt aagtccactc tggtcctctc gtactaggag   1802940
cagatcctct caaatttcct acgcccgcga cggataggga ccgaactgtc tcacgacgtt   1803000
ctgaacccag ctcgcgtgcc gctttaatgg gcgaacagcc caacccttgg gaccgactac   1803060
agccccagga tgcgacgagc cgacatcgag gtgccaaacc tccccgtcga tgtgaactct   1803120
tgggggagat aagcctgtta tccccagggt agcttttatc cgttgagcga tggcccttcc   1803180
atacggaacc accggatcac taagcccgac tttcgtccct gctcgagttg tagctctcgc   1803240
agtcaagctc ccttatacct ttacactctg cgaatgattt ccaaccattc tgagggaacc   1803300
tttgggcgcc tccgttacct tttaggaggc gaccgcccca gtcaaactgc ccgtcagaca   1803360
ctgtctccga tagggatcac ctatctgggt tagagtggcc ataacacaag ggtagtatcc   1803420
caacagcgtc tccttcgaaa ctggcgtccc gatctcttag actcctacct atcctgtaca   1803480
tgtggtacag acactcaata tcaaactgca gtaaagctcc atggggtctt tccgtcctgt   1803540
cgcgggtaac ctgcatcttc acaggtacta aaatttcacc gagtctctcg ttgagacagt   1803600
gcccaaatca ttacgccttt cgtgcgggtc ggaacttacc cgacaaggaa tttcgctacc   1803660
ttaggaccgt tatagttacg gccgccgttt actggggctt caattcatac cttcgcttac   1803720
gctaagcact cctcttaacc ttccagcacc gggcaggcgt caccccctat acatcatctt   1803780
acgatttagc agagagctgt gtttttgata aacagttgct tgggcctatt cactgcggct   1803840
gactttaagt cagcacccct tctcccgaag ttacggggtc attttgccga gttccttaac   1803900
gagagttctc tcgctcacct gaggctactc gcctcgacta cctgtgtcgg tttgcggtac   1803960
gggtagagta tgtttaaacg ctagaagctt ttcttggcag tgtgacgtca ctaacttcgc   1804020
tactaaactt cgctccccat cacagctcaa tgttatagaa ttaagcattt gactcaattc   1804080
acacctcact gcttagacag actcttccaa tcgtctgctt tagttagcct actgcgtccc   1804140
tccatcacta catactctag tacaggaata tcaacctgtt gtccatcgga tacacctttc   1804200
ggtctctcct taggtcccga ctaacccagg gcggacgagc cttcccctgg aaaccttagt   1804260
cttacggtgg acaggattct cacctgtctt tcgctactca taccggcatt ctcacttcta   1804320
tgcgttccag cactcctcac ggtatacctt catcacacat agaacgctct cctaccatac   1804380
ctataaaggt atccacagct tcggtaaatt gttttagccc cggtacattt tcggcgcagg   1804440
gtcactcgac tagtgagcta ttacgcactc tttgaatgaa tagctgcttc taagctaaca   1804500
tcctagttgt ctgtgcaacc ccacatcctt ttccacttaa caattatttt gggaccttag   1804560
ctggtggtct gggctgtttc cctttcgact acggatctta gcactcgcag tctgactgcc   1804620
gaccataatt cattggcatt cggagtttat ctgagattgg taatccggga tggacccctc   1804680
acccaaacag tgctctacct ccaagaatct ctaatgtcga cgctagccct aaagctattt   1804740
cggagagaac cagctatctc caagttcgtt tggaatttct ccgctaccca caagtcatcc   1804800
aagcactttt caacgtgccc tggttcggtc ctccagtgcg tcttaccgca ccttcaacct   1804860
gctcatgggt aggtcacatg gtttcgggtc tacgtcatga tactaaggcg ccctattcag   1804920
actcggtttc cctacggctc cgtctcttca acttaacctc gcatcataac gtaactcgcc   1804980
ggttcattct acaaaaggca cgctctcacc cattaacggg ctcgaacttg ttgtaggcac   1805040
acggtttcag gttctatttc actcccctcc cggggtgctt ttcacctttc cctcacggta   1805100
ctggttcact atcggtcact agggagtatt tagggttggg agatggtcct cccagattcc   1805160
gacgggattt cacgtgtccc gccgtactca ggatactgct aagtacaaag actattttaa   1805220
atacgaggct attactctct ttggctgatc ttcccaaatc attcttctat aatctttgag   1805280
tccacattgc agtcctacaa ccccgaagag taaactcttc ggtttgccct tctgccgttt   1805340
cgctcgccgc tactaaggca atcgcttttg ctttctcttc ctgcagctac ttagatgttt   1805400

cagttcactg cgtcttcctc ctcacatcct taacagatgt gggtaacagg tattacctgt   1805460
tgggttcccc cattcggaaa tccctggatc atcgcttact tacagctacc caaggcatat   1805520
cgtcgtttgt cacgtccttc gtcggctcct agtgccaagg catccaccgt gcgcccttat   1805580
taacttaacc ttattttctg acctttcagt cataaactct tattaatact acagcgtttt   1805640
cggtttattt tcttgttact atttgatata gatattcaat tttcaatgtg cattacttgg   1805700
tgatctctca ccaatggagc ctagcgggat cgaaccgctg acctcctgcg tgcaaagcag   1805760
gcgctctccc agctgagcta aggccccaca agacctctca agactaaaca agaccaatgc   1805820
gcagttcctt atccttagaa aggaggtgat ccagccgcac cttccgatac ggctaccttg   1805880
ttacgacttc accccaatca tctatcccac cttaggcggc tggctcctta cggttacctc   1805940
accgacttcg ggtgttacaa actctcgtgg tgtgacgggc ggtgtgtaca aggcccggga   1806000
acgtattcac cgcggcgtgc tgatccgcga ttactagcga ttccgacttc atgtaggcga   1806060
gttgcagcct acaatccgaa ctgagactgg ctttaagaga ttagcttgcc gtcaccggct   1806120
tgcgactcgt tgtaccagcc attgtagcac gtgtgtagcc caggtcataa ggggcatgat   1806180
gatttgacgt catccccacc ttcctccggt ttattaccgg cagtctcgct agagtgccca   1806240
actaaatgat ggcaactaac aataggggtt gcgctcgttg cgggacttaa cccaacatct   1806300
cacgacacga gctgacgaca accatgcacc acctgtcacc tctgtcccga aggaaagctc   1806360
tatctctaga gcggtcagag ggatgtcaag acctggtaag gttcttcgcg ttgcttcgaa   1806420
ttaaaccaca tgctccaccg cttgtgcggg cccccgtcaa ttcctttgag tttcaacctt   1806480
gcggtcgtac tccccaggcg gagtgcttaa tgcgttagct acggcactaa accccggaaa   1806540
gggtctaaca cctagcactc atcgtttaca gcgtggacta ccagggtatc taatcctgtt   1806600
tgctccccac gctttcgagc ctcagcgtca gttacaagcc agagagccgc tttcgccacc   1806660
ggtgttcctc catatatcta cgcatttcac cgctacacat ggaattccac tctcccctct   1806720
tgcactcaag ttaaacagtt tccaaagcct actatggtta agccacagcc tttaacttca   1806780
gacttatcta accgcctgcg ctcgctttac gcccaataaa tccggacaac gctcgggacc   1806840
tacgtattac cgcggctgct ggcacgtagt tagccgtccc tttctggtaa gataccgtca   1806900
cagtgtgaac tttccactct cacactcgtt cttctcttac aacagagctt tacgatccga   1806960
aaaccttctt cactcacgcg gcgttgctcg gtcagacttc cgtccattgc cgaagattcc   1807020
ctactgctgc ctcccgtagg agtctgggcc gtgtctcagt cccagtgtgg ccgatcaccc   1807080
tctcaggtcg gctatgtatc gtcgccttgg tgagccgtta ccccaccaac tagctaatac   1807140
aacgcaggtc catctggtag tgatgcaagt gcacctttta agcaaatgtc atgcaacatc   1807200
tactcttatg cggtattagc tatcgtttcc aatagttatc ccccgctacc aggcaggtta   1807260
cctacgcgtt actcacccgt tcgcaactca tccagagaag caagctcctc cttcagcgtt   1807320
ctacttgcat gtattaggca cgccgccagc gttcgtcctg agccaggatc aaactctcat   1807380
taaaaagttt gagttcttac tcatttctgt cactgacaga tttattgttt ttttcattgt   1807440
tcagtactac aacttacgtt gtagcgccct gcacattggt tcgtcttgtt cagttttcaa   1807500
aggtctttgt cacttgcttc tctcaagcga caactatatt agtatatcac aactgctttc   1807560
gcttgtcaac acttttttga agatttttaa gtttttttaa actttttttc atcaagtggt   1807620
cctgacgcaa cataccatag tccgtacggg attcgaaccc gtgttaccgc cgtgaaaagg   1807680
cggtgtctta accccttgac caacggacct gagttgttat tttcaactct tactattata   1807740
cagccttttc aaactttgtc aactactttt tctaattttt ttcatttttt ttgcatgact   1807800
tactagtggg tacggatagt aaactcctta aacacaatgc gtaagtctct taatactctt   1807860
tgacgccctc gaaatcgttc attgcttaag acgcgttcta gttcttcttg tttctcttta   1807920
ctttgtttgt ttctataatc tcttagtgtt tcatgaaaga gataataatc atctagccag   1807980
agacccccct cacttatacg atgactgatc tcacccactt cttcataggg ttctttatcg   1808040
tatctacgct tctgactttc ctgtttacgg atatagtcta aaattcgatt tcgaaacttg   1808100
gtcttgaaat atttccttaa acgtggaata tcgtctacca gtccttcttc tctactaatc   1808160
aattcatgta agcagagcat gccttcttgc tcccaatccg acaattccca taaatgaagg   1808220
taatattcat ttctacactt atacacagtc ccttggactt cttcatacaa ttctttaatc   1808280
ataattttcc cctttctaga tacagtctaa cagattagaa aacacatttg ttccattttc   1808340
tccattctgt tccctttagc tcctaaactg cacaaaaaag agaagctcca gcctctctca   1808400
gggttataat tctgcgattt ggtttagatt tacttctgca actgtgtcat taccaaacat   1808460
agagataatc attttcactt tgttattatc aatttctgta atcttaccag tgtagtctgc   1808520
aaaagcacca tcaataatac gtacagtttg accaatctca acatcgaaat caaattcttg   1808580
aacagtttgt cccatagata ccaaaatgtc gcgaatttct tgttccaata atggagttgg   1808640
ttttgatctg ttcccgtgtg atccgacaaa tcctgtaaca tttggtgtgt ttcgaacaac   1808700
aaaccaagct tcatctgtca tgaccatttc tacaagaaca taacctggaa agcgattttc   1808760
ttctacttct tttctctttc catttttttc aacttgcact gtttgtgttg gaatttcaac   1808820
gcgtagaata ttatccaaca tattgtaggt ttgtgcacgt tgtaatagat tttctttcac   1808880
cttattttca taaccagaat aagtttgtaa aacaaaccac cctttatcaa aactatccat   1808940
gatatttcct ttcataaata gaagatttct agtgtaatta actccactaa tcttctaaaa   1809000
aatgttaata aatcgaatca aacctgaaac aatcaactgg tcaaaaatgt aaataattac   1809060
tacaaagaaa gctgtgtatt ccatgataga acgaaaatct ctccagcttt ccttgcgagt   1809120
tggccatgtt gtgtctttaa gaagtctaaa aatatctcca ataaaacgca tcgctctctc   1809180
ctatctcgtt tctctgtgtg tagtgtactt gccacaatgc ttacaaaatt tatttacttc   1809240
tagtcgtgta ggcttgaggt ttccgctgat cttgattgaa tagtttctcg aaccacaaac   1809300
cgcacaagct aggcttgctt tttttagtgc cataacgcct ccatcttatc cattataaca   1809360
agaaagctag gctttgacaa gcatcttagc gaaatagatt gactatcgaa tcccatattg   1809420
tttgagcctt ttccttaatc ttcgcatctg agatagcccg gctagcctca tctactagac   1809480
tttgcgcacg ccctcgaata tcagacaaat tatcatctgt ctggctatta tcattggttt   1809540
gtacttgtct ttttgtattg gctggtgcaa ttccattttg cttataagca ttttcaaccg   1809600
taaaggtact tcctggcgta taaggtaaaa tggtattggc aatgtttcta aagacatgag   1809660
ctgcaccgtt tgaagtagag ccagctagat agtggttttc atcagtggtc ggaaagccaa   1809720
gccagtggct aatcactaca tccggagtat aaccaattac ccactggtca cttgtgtact   1809780
ccggattgaa aactgcttca gttgttccag ttttccctgc catgacatag tctgcaggcg   1809840
atgaactaat accggtaccg ttggtgaaag tccccaacat catactggtc atcttgtcag   1809900
ctacagactt atcaatcacc cgtttttgtg aatttttatg actcgcaata acttgtccac   1809960
tagcattttc aattctacta ataaaatgag cttcaggcat taaaccttca tttgcaaagg   1810020
cggcgtatgc ttgagccatt tgaagagggt tggtttcaac accgcttccc aaggcgacac   1810080
caagaacacg gtcgaccttt tccatgttga gtccgaattt ttcgcctgcc tcaaaagcct   1810140
tgtcgacacc caaatcatta acagtggcaa cagcaggtag attaagcgat tctgccaagg   1810200
cttgatacat aggaacttct cgactcgttt tgatccctgc atagttatca accttatagc   1810260
tgtcatactg catggtatgg ttatccaact gcttattcaa agcccagctt gcttcaactg   1810320
ctggcgtata aacaactaaa ggcttaattg tagaaccagg actacgcttt gattgggttg   1810380
catagttgaa attccggaat ccagttttat cattgtcagc aacttgaccg acaactccac   1810440
gaactccccc tgttttcggt tcgagggcta cacttcctga ttgagcaaac gttccatcct   1810500
ctgccctcgg aaatagcgat gtgttttcat aaacaatctg catatttgct tggtagtttt   1810560
ggtccagctc tgtgtaaatg cggtagccat tattgacaat ctcttcctct gttagattat   1810620
acttggaaac agcttcatta accaccgcat caaaataaga ggggtaacgg taatctgaga   1810680
tttttccttc atacttatcg tgcaattgcg aagtcatatc aacttcagca gctttggttt   1810740
cttggttttt atcaatatat cctgctgcaa ccatattctg caagacagta tcgcgccgat   1810800
tagtagaatc ttctacggaa ttcaagggat tatacagttc cggccccttg agcatccctg   1810860
ccagagtcgc agcttgatcc agactcactt ctgatgcaga aactccaaag tatttcttac   1810920
tcgcatcttc tacaccccac acaccatttc caaaataagc gttgttaagg tacatggtta   1810980
gaatttgctc cttactatat tttttgctta attctaaggc aaggaaaaat tctttcgctt   1811040
ttctctcaac agtttgatcc tgcgataaat aggcgttttt agccagctgt tgggtaatgg   1811100
tagagccacc acctgaacgt ccagcagtga caatagccaa gaaaaaacgg ccatagttaa   1811160
tcccgtcatt tttatagaaa gaacggtctt ctgtcgcaat aacagcattc tgcaagtttt   1811220
tactgatgtc agtcagctca acataggttc ccttttgacc agacaaggca ccagcctctt   1811280
tttcttcacg gtcaaaaata agagtccgag ttttcaaggc attttgcaaa tcattgacat   1811340
tggtcgactt ggctacagca aacaaataga ttccaactag caagcctgca ctcaaaccta   1811400
gtataaggat aatctttgtt agatgataac gacgccagaa ttttcgaatc ggacctactt   1811460
gggctaattt ttttcgatca ctacgagagc gacgtaagat agtagaatca gagtcctcta   1811520
gttcacttgt ttctttttta aaaagagaaa gaaatttctc aaataattta tctaatttca   1811580
tgcgtttatt ttatcatctt catcatagga agacaagaat ttagctattt cctatccaaa   1811640
tagggctttt tttgttacaa tatctgtatg caattcacat ttacattacc cgcctctcta   1811700
cctcaaatga cagtaaagca attacttgag gaacaactcc tcatccctag aaaaatccgt   1811760
cattttttga gaatcaagaa acatattttg ataaatcaag aagaagtcca ctggaaggaa   1811820
atcgtaaatc ctggagatgt ttgccagttg acttttgacg aggaagatta ttcccaaaag   1811880
acgatccctt ggggcaaccc agacttagtg caggaagttt atcaagatca acacttgatt   1811940
attgtaaaca aaccagaggg gatgaaaacg catggtaatc aaccaaacga aattgccctt   1812000
cttaaccatg tcagtaccta tgttggccaa acctgctatg tcgttcatcg tctggacatg   1812060
gaaaccagtg gcttagttct ctttgccaaa aatcctttta tcctgcccat tctcaatcgc   1812120
ttattggaga aaaaagagat ttctagagaa tattgggctc tagttgatgg aaatatcaac   1812180
agaaaagaac ttgttttcag agacaaaatt ggacgtgatc gccatgatcg tagaaaaaga   1812240
atagttgatg caaaaaatgg gcaatatgct gaaacgcatg taagcagatt aaagcaattc   1812300
tcaaacaaga cttccttggc tcattgcaag ctaaagacag ggcgaaccca tcagattcgt   1812360
gtgcaccttt cgcatcataa tcttcctatc ctgggagacc ctctctataa tagtaaatca   1812420
aagacaagcc ggcttatgct tcatgccttc cgactttcct ttacccaccc acttacttta   1812480
gagaagctaa ctttcactac cctttcaaat acatttgaaa aagaattaaa aaagaatgga   1812540
tgatcgtgtc atccattttt ccatataaaa aagcaagacc acaaagcctt gctttctatc   1812600
aactcaagaa ttatttagca atttttgcga agtattcaag agtacgaaca agttgtgcag   1812660
tgtatgacat ttcgttgtcg taccatgata caactttaac caattgttta ccgtcaacgt   1812720
caagaacttt agtttgagtt gcgtcaaaca atgaaccgta agacatacct acgatatctg   1812780
aagatacgat tggatcttct gtgtaaccgt atgattcgtt tgaagctgct ttcatagctg   1812840
cgttcacttc atcaacagta acgttctttt caagaactgc taccaattca gtaactgatc   1812900
cagttggagt tggaacgcgt tgtgcagatc cgtcaagttt accattcaat tctgggatta   1812960
caagaccgat agcttttgca gcaccagttg agttaggaac gatgtttgca gcaccagcgc   1813020
gagcacggcg aaggtcacca ccacggtgtg gtccgtcaag gatcatttgg tcaccagtgt   1813080
aagcgtggat agtagtcatc aatccttcaa caacaccaaa gttgtcttga agagctttag   1813140
ccattggagc caagcagttt gtagtacatg aagcacctga gataactgtt tcagtaccgt   1813200
caagaacgtc gtggttagtg ttgaatacaa ctgttttaac gtcgtttcca ccaggagcag   1813260
tgataacaac ttttttagct ccacctttaa ggtgtttttc agctgcttct ttcttagcaa   1813320
agaaaccagt agcttcaaga acgatttcta caccgtcagt agcccagtcg atttgttctg   1813380
gatcacgttc agcagaaact ttgatgaatt taccgttaac ttcaaatcca ccttctttaa   1813440
cttcaacagt accgtcgaaa cgaccttgag ttgtgtcgta tttcaacaag tgtgcaagca   1813500
taactggatc tgtaaggtcg ttgatgcgtg taacttcaac accttctacg ttttggatac   1813560
gacggaaagc aagacgaccg atacgtccga aaccgttaat accaacttta actaccatta   1813620
gtgatttcct ccttatgaaa atcatgaaat ttttattgtg aaaagagtaa cttgaatcac   1813680
tacaaatcac ctttcaacaa acctattata caactatttg agttgaattg caagtatggc   1813740
cattgttttt ctatgttagt ttctttttaa gactgtaaac caaggaatcc cttactattc   1813800
atagcataac gattctatag gatccatttt actaatctta cgcgccggga agtaggctga   1813860
gacataacca agtaatagag cgaaaactag agttcctaaa acagataaaa gatttaattt   1813920
aaaaacctta gtgatggatg ggtaaaagtg acttacaatc gcattcgcca aacttcccac   1813980
cccttgtgca accaaaaatg ccagcagcaa ggcgatgcct acaatccaga tagcctcgta   1814040
aataaaaatt cctttgacat cacgattctg ataaccaact gctttcatga cacctatttc   1814100
cttggaacgt tgcatgatat tgatgtaaat aatgatacca atcataaccg ctgctaccac   1814160
aatagcttgt gatgaaagca caatcaataa tccctgaata acacgaataa aggtaatcac   1814220
aatatcaaga actctctgtt gagaaagcac agtatacttc ttatttttct gtaattcttc   1814280
tgttactact tttgtctgtg atggatcttt gagttccaag ataaaataag atacagcttt   1814340
cgtaaatcca gcctctttca aaatcgtttc catttgatga gacagcatga aactgttgct   1814400
gtcctccatg tcatcttcat cattgattac acgtacaatc ttcgtttgaa attgagcaat   1814460
cttactagtt tcggcagcac tttctacaat gctggctgag actgatttgc caataagatc   1814520
attagctgtc aaattttttc ctgtctgttc attccaattt tttagtaaac tgcttggaat   1814580
cgttaatccc tgttcatttg tatcagtata gagggatcca gccaacactt tgtccgtctc   1814640
attattacta acagagatac ttgtatcatc ataaagactc actacttgag cataagaagg   1814700
catcgtttga ctcagatcca tttcttgccc atctatagta atatttgaca tgttcatccc   1814760
aaaaggactc tccaaatatt taatagcttc tttcccaact gtatccgtga tatatagtca   1814820
attgaaacaa gagcaggata aaaaagcctc gtaaaaggta ttgcaacttg gtaatacctt   1814880
tttgaggtgc tttttgatat gagcccatgt tttctcaata ggattgtact caggcgagta   1814940
gggaggaaga ggtaaaagtt tatgcccaaa ctcttcgcat aaaagttcta gcttccccat   1815000
tctatggaat cttacattat ccataataat aaccgatggt gtgtttaatg ttggtaagag   1815060
aaaattctga aaccaagctt caaaaaagtc gctcgtcatc gtctcttcgt aagtcattgg   1815120
agcgattaat tcaccatttg ttagacctgc aaccaaagaa atcctctgat atcttcttcc   1815180
agatactttg cctcttatta attgaccttt taatgagcga ccatattctc gataaaaata   1815240
agtatcgaat cctgtttcgt caatctaaac aggtgctagg tgctttaaac tattaaaatt   1815300
cttaagaaat aaggctactt tttctgggtc ttgttcatag taggtgtggt tcttttttcg   1815360
agtgtagccc atagctttga gcgtatagtg gatggtagtt ggatgacagc caaattcaga   1815420
agctatttca gtcaaataag cgtctggatt gtcagtaaga tagtttttaa gtctatctct   1815480
atcaaccttt cttggtttta ttccttttac ttggtggttt agctctcctg ttttctcttt   1815540
tagctttaac cagccataaa tggtattacg tgagatttgg aaaacgtgtg atgcttctgt   1815600
tatactacct gttcgctcac aataagagag aactttttta cgaaaatcta ttgaatatgc   1815660
cataaaaaga ttataccaca ttgtgtacta tttttggttc attttactat atttgaagag   1815720
gcgtttaaac tatctgacat aaaactcgtt ctagaggaaa gacatccttt aaaaagttag   1815780
tttattttac aacttagaca tcaaggtagg ttaacccctt catggaaaaa tcaagactct   1815840
tagcactatg ggttaaacta ccactggaga cgtaatcaat cgctaaacca cgaaaacggc   1815900
taatagtggt catatcaata tttccagaac attcaatccg agaacgtcct gcaattaggg   1815960
taatggcctg ttcaatctgt tccaatgaca tattatccaa catgataata tcagcacccg   1816020
ccgccgcagc ttcttcggca gcagcaaggc tttccacttc cacctcgacc attttcacaa   1816080
aaggggcata ggcacgcgct tgagcaattg ccttttgaac actacctact gccgcaatgt   1816140
gattgtcttt tagcaggata gcatctgata aattaaagcg atgattatag ccaccgccaa   1816200
ctctcacggc atatttctca aaaagacgta aattaggagt agtttttcga gtatcaaata   1816260
ccttaatgca atcatcgcct aaggcttcta cataagcagc tgtcatcgaa gcaatccctg   1816320
ataaatgttg taaaaaattc aaggcaacgc gttcacatgt taagagactt ctcaccgagc   1816380
ctatgatttc taaaaccaaa tcgccactag tcaaacgatc cccatcctta aattgatgag   1816440
gattctggaa ggtcacctcg gcatcaaata gggtaaaaac cctttgaaaa acggttagcc   1816500
ccgctaaaac accagcttcc ttggcaaaaa gcgacacctt ggcttggcca tgatgatcaa   1816560
aaatggcatt ggtactgtaa tcttcggaat gaacatcttc tcgcaaggct gctttcaatg   1816620
tatcatctat ttgaaaaggg gttaaatcag ttgaaatgat tgacatcact aggtcctcta   1816680
tttttaatat cacttgtaag cattagaggc aatcactatt aacttccata ggaaatcaca   1816740
agcctgaata cctcattttt aattctaaca agtgtcaaga caattgtcaa gacaattgta   1816800
ttttttttgt gtataatagt caagtaccaa taggaaacag gtggtctttt gagcgccaaa   1816860
attgccaacc tatttccata ttctaactga aaggacaatt caatgattca tttaataatg   1816920
attagcgcca ttgctctagc cattggaatt ggttaccgca ccaaaatcaa tattggcctg   1816980
ctggctattg ctttttctta cctcatcgca accactctca tgggattaag ccccaaagaa   1817040
cttcttcatt tttggccaac ctcactcttt tttaccattt ttagcgtctc tctcttttat   1817100
aacgttgcaa caactaacgg tactcttgat gttttggctc aacacattct ctaccgcaca   1817160
cgcacccacc ctaacgccct ctacatgatt ttatacctga tggcaaccct tttgtctgct   1817220
ttaggtgctg gatttttcac tactatggcc gtttgctgtc ctctagcgat taccctctgt   1817280
caaaaagcgg acaaacaccc tttgattgga gctcaagccg tcaattgggg agcttcagga   1817340
ggggctaatt tgataaccag tagctcaggc attgtctttc aaggcctgtt taagcaaatg   1817400
ggatgggaag agcaagcttt ttcacttggc aatcatatct ttatcgtcag cattatctac   1817460
ccactcatcg tcttgctttt attatcctgt tacagtcact atagtaaggg aagaacaaac   1817520
tcatccttga ctattgacca accaccactc ctcagcaagg ttcaaagaca aaccaccttg   1817580
ctcatgatca gcagcatggt tttggtttgg ctttttccct tgttgcatct cattttccca   1817640
aacatcgcct ggatagctac ttatcaaaaa acatttgata ttggctttgt ctcaatactc   1817700
atggtctgcc tcgccttaag gctcaaatta gggaagcaag aagccatttt agctaaggtt   1817760
ccctgggcta caattatcat gctctgcggc atgagcttac taatgtctct agcggtcaag   1817820
tcaggtttag tcacactgat agggcacctc atgacaacaa ccattcctca tttctggtta   1817880
cctctgttct tttgtgtgat agccggagtg atgtcactct ttagttccac cctatccgtt   1817940
gtagctccag ccctctttcc catcattgct atcatcagtg ctcaaaatcc tcagattgat   1818000
attcacttac tcacaacagc caccgttatt ggcgctctat ctactaatat ctcacccttt   1818060
tcatcagctg gttctctcat tcaactctca cttcccaata tagaggaacg tggccttgcc   1818120
ttcaaaaagc aaattattct gggtgtcccc atcagcttaa gtttgggact cttgaccacc   1818180
tggattctca tccttctagc ttccttaagt tagatttatt atctaactta agggtggact   1818240
tggtataata aagtagacac aaaattaagt ggaaacgagg aaaagtcatt atgccaagaa   1818300
aaacctttga taaagccttc aaactctctg ctgtaaatct catcctgtaa aaatgattag   1818360
ttcaacttta aaaattcatc ccaatagtct ttatcgatgg attcaagaat atgaaaaata   1818420
tgaagaaagt gcgttcccag gacatgggag cgcacttcgt catactcaat ttgagatata   1818480
gtgaaatgaa ataagaacag gacaaataga tcaggatagt caaatcgatt tctaacaata   1818540
ttttagaagt agatgtgtac tattctagtt tcaatctact atagtaaagt tgactttcct   1818600
gtaccatttt taccagtaat taatgtcacg tctgaactcg aagtatcaaa agaaatatta   1818660
tcaaacaatt tacgatgatc caccctatac gaaatatttt ctactttcat tttttctcct   1818720
tttgaactaa tagcaaaaga aacagttctg ttttcatact ctttcccctt catctatatt   1818780
attcgtaatg aaaaataaaa aataaaattt ttttaaatga ttatgattta gaatttattt   1818840
aatatattaa aagaagatat gaacaaataa attgggagat tgaaattcat ttctagcaat   1818900
ttgttagaag tcacagtcta ctattctaac cacagtatac tatatgtgtt acaagaaaag   1818960
actcaaaaac ttctcgtcag tgtaagaatg tttgaaacac tatttaaaac taaataacta   1819020
taagaagtag atcaggtgaa caatttcagt acctactcta taagctatac gaagatattt   1819080
ttcaacatga tggatacaac gatcactctt ttaaagccat cttatttaga aaagagaaac   1819140
catttaagca tagatgggac cttcttgccc tgttttaaat ttttcttaaa ctagagtctg   1819200
taaaagattg gcttcatttt cacattttct cctaggagga atgtcgtaat gcaaaagaat   1819260
taaattcaaa taaatcatag cgatgacgac taatcgagta ctcaaacgga gttccgttat   1819320
ccaaataagc cacttgttct acttcaaata ccggttccgt tggaaggagc tgcaagtaat   1819380
gttgctcatt ttctgaacta gaagaagctc gtaagatttt tgtagcactg gcaatatgca   1819440
atcctaactt tccttcaatg taattgtaaa tcgatttttg taaaatatct tcagtaatac   1819500
ctggaataac atcggtactc atataagttt gttccagaac ataaggttta ccgtcaataa   1819560
tacgcaggcg gtaaatatta taaactggac tctgcaaagc gacctgtagt ttttctgcta   1819620
aaaattcatt tgcaaattct aatttgaagt gaataatcct cgagtcaatt gtagaatgag   1819680
catcttcaga tatttttgtc agtccccgga tatctctttc tggaacgatt aattttcttt   1819740
ttgagctgcc acgagagaga acaaaggttc cctgcccacg ttttctaaaa attaagccct   1819800
cagaaactaa caagtctaaa gcttttttga tcgtcattcg actacaggca aactgtttag   1819860
ctaatgtcat ttcatcaggc aattgttcgt tcatggtata tttattacaa agaatctttt   1819920
cacgaatctc attgtaaata aataaatatt ttgtactcat ttaatctggt tctctctata   1819980
atattctaat agtagtataa caaagttcaa gaaatgaggc aaacacaaga tatgtatcaa   1820040
caatttttaa aaatgtctag acaaatttta aaattatgct atactttatg tatagaataa   1820100
tagaaaggag gttgagcatg aaaaaaaagt tagtatttcc taatctgttt tggtggggag   1820160
ctgcttctag cggacctcag acagaaggtc aatatggaaa agtacatgaa aatgtgatgg   1820220
actactggtt caaaacgcat ccagaagatt ttttcgataa tgtcggacct cttgtagcca   1820280
gtaacttttt tcatacttac accgaagatt tccacttgat gaaggaaatt ggagttaatt   1820340
ctttccgcac ttccatccaa tggagtcgac tcatcaagaa tttagagaca ggtgagcctg   1820400
atccaaaagg tattgctttc tacaatgcca tcattgaaga agctaaaaag aaccagatgg   1820460
atcttgtgat gaatttacat cattttgatt taccagtgga acttcttcaa aaatacggtg   1820520
gttgggaaag caaacatgta gtggagttat tcgtgaagtt tgccaagact gctttcacat   1820580
gctttggaga taaggttcat tactggacaa ctttcaatga gccaatggtc attccagaag   1820640
caggatactt atatgctttc cattatccaa atctaaaagg aaagggaaaa gaggccgtac   1820700
aagtcatcta taatctaaac cttgctagtg caaaagtgat tcaactatat cgctcattag   1820760
aacttgatgg aaagattggg attattttaa acttgacacc tgcttatcca agaagtaatt   1820820
ctccagaaga cttagaagca agtcgattta cagatgactt ctttaacaaa gtcttcttga   1820880
atccagctgt taaaggaact ttcccagaaa gattggtaaa acagctagag agagatggcg   1820940
tgttatggag tcataccgaa aaagagcttc aactgatgaa atcaaatacg gttgattttc   1821000
ttggagtaaa ctactaccat ccaaaacgtg ttcaagcaca agcaaatcct gaggaatatc   1821060
agacgccctg gatgccagac caatacttca aagagtatga atggctggag cgtcgcatga   1821120
atccatatcg tggttgggaa atttttccga aagccattta tgatattgct atgattgtga   1821180
aggaagaata tggtaatatc ccatggttta tcagtgaaaa cggaatgggt gttgaaaacg   1821240
aagcacggtt tatcgatgaa aatggagtta tcgatgacgt gtatcgtatt gaattttatg   1821300
aagaacattt aagatggcta cataaagcca ttgaagaggg aagtcactgt tttggatacc   1821360
acgcttggac cgcatttgat tgctggtctt ggaataatgc atataagaat cgttacggat   1821420
ttatctccgt tgatttagaa acgcaaaaga gaaccatcaa gagctcagga agatggtatc   1821480
gcaaagtaag tgacaataac ggttttgaag tagaaattga ggagtaaaga gaggagatat   1821540
tcatatgaaa aactcaaaat ttatagacca atttgccacc tttgctggta aactagggaa   1821600
ccaaattcat ttaaaaaccc taagagatgc attcgtaaca gtaatgccat tatatatttt   1821660
ggcaggttta atcgttcttt tgaacaacac ggtatttaag tggattttcc aaggggatac   1821720
attaacaaga ttccaatatt ggggaataac aattgcaaac ggtactttaa gtatttcagg   1821780
tatgattatt gctgtaatgg ttggttattt cttagctaaa aacagagatt tcgaaaaccc   1821840
gttagcagca tcaatgctat cattagtttc tttaattgtg atgatgccaa atacagtttc   1821900
tgtagttcct gacggagcaa aagatgcggt aaacatttca ggtgttcttt cattcaacaa   1821960
cacaggtaca ggcgcaatgt tcgccggggt tatcgtagcg attattgcaa cagaattatt   1822020
cattgaatta tcaaacgtta aagctttaca aatgaacctt ggtgaaaata ttccaccagc   1822080
tgttagtaga tcatttagcg tattacttcc agtcatgacc gtcatctcct tatttggggt   1822140
tgtttcagca ttattattca atataactgg aatgaactta atctcaatca ttacaatctt   1822200
tattcaagaa ccaattcgtc atattggtac aagcttaatc ggggtcatta ttatttactc   1822260
tttaggaaat atgttatggc tatttggtat tcaccaagca gttatttaca gtgccatcct   1822320
agaaccatta ctattaatta acattactga aaacatcact gcagcaaata atggacaagc   1822380
cattccacac atcatcaacc tatcacaaat acaaacattc gctttaatgg gtggtagtgg   1822440
atctacatta tgtttattaa tagcaacatt cttagtgagt cgcaatgctg tctctaaaaa   1822500
cgtggctaaa ttatcttttg gacctggtat cttcaatatc aatgaaccag tattattcgg   1822560
ttacccaatc gtttataaca tttcattagc tattccattt atcacagttc cagtccttgg   1822620
tattttaatc agctacttag caacagttac agaattcatg agtcctgcat ttatacaagt   1822680
tccttggact acaccagtat tcttaaatgc atggttagca acagcagggg acgtgagagc   1822740
agttctagtt caattcatca tctttgcact tggagttctt ctatacattc catttatcaa   1822800
agttaatgac aaagttgttg aacaagaaat ggaaggttaa gattatgaaa caaattttat   1822860
tagtatgtaa tgcgggaatg tcgacaagta tgcttgttaa aaaaatgcaa caaagtgcga   1822920
ctgaacgtgg gattgaaatc tctatccaag caaaatcaat gacagaagct aaaaagaata   1822980
tccatgaagc agatgtcatt ctaattgggc cacaaattcg ttatgagtta cttgctgtga   1823040
aagaaattgc aggaaatatc cctgtagata ccattgatat gcgggattac ggaatgatga   1823100
atggagcaaa agttctggaa caagcacttg catggatagg agaaataaga tgacagaaga   1823160
aatggaatat atctgttttc agctcattgc caatagtgga gcagccaaat catcctttat   1823220
tgaagccatc caactagcta aggcaggaaa tttaaaagaa gcgaaaatta aagttgaaga   1823280
agcggaagac tccttagtag aagcgcacaa gattcactct aatctcatac aaaaagaagc   1823340
tactggagaa aaaataggat tctccttgct atttatgcat gcagaagacc aaatggcttc   1823400
aacagagatt attcagttgc tatctaaaga attcatcgat ctctatcaaa ataaatagga   1823460
acactgtcat tcccatctgt ctttattaat gacgactaca ttgtaggaac ctccaaaagt   1823520
tggacaaaat gattgaaagg attggatcct gcattacaca agatccaatc cttttctttt   1823580
actctagttt ttataatatg ttgaatctag aatagtccac tgtagtttct aaaaaattgc   1823640
tggaaatgga tgttaagctc caatttattt gtttatatct tatttcagtt tactatacta   1823700
gcttattatt ctagtgaaaa attgaatgag ccactattta tttaatatgt atgatgaggg   1823760
aatgactcaa aaacttcttg tcgatataag aatatctgag atagtatttt aaaacgaaag   1823820
gactataaaa gctcatttcc ttcgcactta ttttatagag atctatcatt atactcttta   1823880
gaaatcaaaa agcaacacac cttgtcatcg ttttatcgta aatctgttaa tgagggggct   1823940
agtcttatct gcaatctcaa atcagtgttt tgagctgaat ggcactcgtt ttctagtttg   1824000
ctctttgatt ttaattgggc cttagtaaat actactctta aattaaacta tagtgaattg   1824060
aaataagatg tgaacaactc tatcagaaaa gtaaaattaa tttctataaa tgttttagca   1824120
attgtttcgt actattttag attcagtcta ctatactata ttttttatat atcaaaatga   1824180
aataagaaca ggacaaatcg atcaggacag tcaaatcgaa ttctaacaat gttttagaag   1824240
cagatatgta ctattctagt ttcaatctat tatatatttt gtttctattc tagtttttca   1824300
aaaagggcaa aaaggcctca atatcataaa aaggcatcct atcaggtgtt caaaaacctt   1824360
gataggatgc cttttatcat agaaaaatta ctggatcttt ccctcaaatt gagtttttgt   1824420
cttgcttcta gactgataaa caattattta cggcgtcctg gtctttcttt gtagccatag   1824480
tatgcatctt cgatgatttc ttgcatatgg tctaccattg gaagacgtgg gttagctggt   1824540
gaacattggt cttcataagc caggaaggct aatttacgag aatgttcttt ccattctttt   1824600
tcgtcaattc cttggtctct aaaattcatt tggatcccaa tacgttcacc gagttcgtag   1824660
acagcttttg cgtaagattc aaccccttct tctggagtag aagctggaag tccaagcatg   1824720
cgtgcgatat cttggtattt ttcatctgca cggtagtagt tgtacttagg ccatgttgct   1824780
gtcttagctg gacgtgtacc gttgtaacgg ataacgtatg gaagcaagat agcatttgta   1824840
cgaccgtgga ttgtgtggaa ttgcgcacca atcttatggg ccattgagtg agaaatacct   1824900
aggaaggcat tggcaaaggc cataccagcg attgttgaag cgttatgcat tttctcacgt   1824960
gagtggaagt ctgcattctt aactgagctt tcgagatttt caaagaccaa tttaatggct   1825020
tgaagtgcta aaccatcagt gtagtcacta gccatttgtg atacgtatgc ttctgtcgcg   1825080
tgagtcaata cgtccatacc agtatcagca gcaacaaatc ctggaactgt caataccaaa   1825140
gcaggatcta cgattgccac agttggtgtc aatgagtagt cagcgattgg gtatttacgg   1825200
ttgtttgctt tatcagagat aacggcaaat ggtgttactt cagatcctgt accagatgta   1825260
gttggaatcg cgatgaattt agtcttctta ccaagcaatg ggaacttgaa ggcacgttta   1825320
cggatatcca tgaatttttg gacaaggtca cggaagtcca cttctggttg ctcgtagaag   1825380
agccacatta ctttggcagc atccattgga gacccaccac cgagtgcgat gatggtatct   1825440
ggtttgaagg cacgcataat ctcagtacca cggtttacag ttgtgatatc tggatccggt   1825500
tctacatccg caaagatttg gtaaacaacc ttattgcgac gaaggtccag ttgttcgatg   1825560
atacgatcaa ggaaaccaag ctctaccatg gcatggtcag taacgatcat gacacgttca   1825620
acgtcacgac atttttgaag gtattgaatt gaatcacgtt caaagtatgt ttttgaagga   1825680
agtttcatcc attgcatgtt atttctccgt cttccgactt ttttgatatt caagaggtta   1825740
atggcactaa cgttatcccc aactgagttg cgtccgtaag aaccacatcc aagtgtcaat   1825800
gatggcaaga aggcattgta aacgtccccg ataccaccaa aagtagaagg tgagttacag   1825860
ataacacgaa tagctttaac agctttacca aattctttag tcaattcttc gtcagctgtg   1825920
tggatagctg ctgagtgtcc aagaccgtta aattcaacca tttgacgagc cttagtaata   1825980
ccatcttcac ggctttcaga tttcaaaact gcaataactg gtgacaattt ttcacgagtc   1826040
aatggctcat tttcgccaac ttctttacat tctgcagcaa gaatgtttgt tccttctgga   1826100
actgtaaatc ctgcttgttc tgcaatccaa gttgctggtt taccaacgat gtcagcgttc   1826160
aattttgcac cagcacagtt tttgctgttt gctttgacgc cgaagcagaa ctcttcaaga   1826220
agagcttttt cttttttgtt tacaaagtaa gtgtggtaag atttgaactc tgctacaaat   1826280
tcatcgtaaa tttctttatc aatgataact gcttgttcag atgcacagac cataccgtta   1826340
tcaaatgatt tagacatgac gatatcgtgt gctgcttgac gaatgtttgc tgatttttca   1826400
acataagctg gaacgtttcc ggcacctacc ccaagagctg gtttaccaca tgaataagcc   1826460
gccttaacca tggcattacc acctgttgca aggattgtcg caacaccttc gtggttcata   1826520
agggcacttg ttgcttccat agatggttga gtaatccatt gcacacagtt ttcaggagca   1826580
ccagctgcga tagctgcatc gcggacgata cgagctgcat gagcagatga ttcttgtgct   1826640
gatggatgga aggcaaagac gattgggtta cgtgtcttca atgaaatcaa tgatttgaag   1826700
attgctgttg atgttgggtt tgttgttgga gtaataccac aaacaacacc aactggttca   1826760
gcaataagag tcaatcctgt tacatcgtct tcttcgataa cgccaactgt cttagtgtgg   1826820
cgcatgttgt ttactacgtg ttcacaggca aacaagttct tagttgcttt gtcttcaaat   1826880
acaccacgtc ctgtttcttc aaaggcatgt aaagccaatt ctccgtgggc atccaaagct   1826940
gctactgatg ctttggcaac gatgtagtca acttgttctt gatccaattt acgcatttct   1827000
tcaagggcaa ctagagcttt ttgaaccaac tcatctacgt gtttttcagc aacgagtttc   1827060
ttttcctctg gtgtcacagt ttttttatca gccatatttt cctccatagc tttcaaggaa   1827120
cgatatcctt tgttaatttt ttcacaagtt tattataacg cattatttca actttgtaaa   1827180
cagtttcata aacatttcac aaagaatttt taaactcttg tgaaactttt ctcattttct   1827240
tttcttatca ggttttatct ttgaagtttg tgaaatttat ttcaaatatt ttttatttca   1827300
caaacttgct tggaagaggg atttggaaag aaagggattt gcaggtaagc gcttaccttg   1827360
cgattctaat aatacctcct ttgataagga ggctttattt ttgttgaaaa acgccttgtt   1827420
taaaagttcc ttcataaacg acttcttgtt ctgttgttag tttccctttt ccttcagcct   1827480
gaccatttac aaaatcacct tcgtaggtcc agccttcttt agattgaaag gtaccttttc   1827540
cgttgaaggc tccattgttg aagccacctg tatattggtc tccattttgg aaggtaatgg   1827600
taccttggcc attcatttta ccgcggacaa gactgccatc ataaacaatc gttccattat   1827660
cgagttttaa gacacctttt cctggaatat ttagaaaaaa gacgagtaca gcacagaaaa   1827720
caatggtaac tactgccaaa agctctaaac gtggacgagt cagatagaca cgatactttt   1827780
cgtaaaaatt cgtaagattt tccaccttaa ctctcctttt ctaaacgttc taaccaagct   1827840
tgacagccct cttgaacacg tcgataggtt tcttcaaaat ctcctgtata ccaagggtct   1827900
ggaacacttt cagatgaaaa tgagtaaatc ttatcttgac agtctactgg acacatctga   1827960
cgtaagtcag aaatatttga agcgtccatt ccgataatat aatcaaaggc ttcaaaatct   1828020
tccttactaa tctgaagcga tgtcttgttc ttgtcataag gaatctcata ctcttgaaaa   1828080
attccctgag tccccttatg aatcggattg ccatgttccc aagaggaagt tgctcgactt   1828140
tggatttcgt agttatctgt cattgatttc ataacaaact cggccatagg gctacggcaa   1828200
atatttccca gacagacaaa gactaatttt ttcatcccat ttcctttctt ttatagaaaa   1828260
cgggagttcg tgatcccgtc ttatttttca attgcgcctt ctagtgaagc tgtttctttc   1828320
agcggtaata ctgtcttgat agcagctagt tcaaaagtca agtaaactcc atctacgtca   1828380
agaactattg ttcccttctc cgtatctact tcatcgactg ttccataaag tccaccgatt   1828440
gtaatcactt catagccttt ttgtagttta tttaagcttt ccatacgctt ttgagcttgt   1828500
ttcttttgag aacgttgcat aaagaacatc aaggccatca tacctacaag catgattaaa   1828560
aaagtaatat ttggattcat tgttttctcc tttgtctttt acataggact actatatcaa   1828620
atttcagcta cttttacaag attgtacctt acttttctgg taagaaaaac cagagcttac   1828680
gccctgattt ttaggattat ttcaagtttc gaacaacttt tacaagattt tctacagtaa   1828740
agccatattc tgccaatact tttggtgctg gggcagaggc tccgaaggta tcaataccta   1828800
gaacggcacc atcgagacca acatatttgt accagttttg acttgcaccc atttcgactg   1828860
caacacgacg gcggactgca tttggaagaa tttcttcctt gtaagctgca tcttgtttat   1828920
caaagacatc tgtagatggc atgctgacta cgcggatttt ttcgccttga ctagccaatt   1828980
ctttagcagc tgagacagca agattaacct ctgaacctgt cgcaatcaag atggtatcaa   1829040
agtcggctgc attttcatat acaacataag cacctttagc aaccttgtcg aagtctgttc   1829100
catcttcaac agtcaaattt tgacgtgtca agacaagggc agttggtgtt ttctcacttg   1829160
tcactgcaag gtaccaagct gcttgcgttt cacgcgcatc tgctggacgg aaaacattta   1829220
gatttggcat agcacgaaga cctgctaaat gctcaactgg ttcatgagtc ggaccatctt   1829280
ccccaactgc gattgaatca tgggtaaaga cataagtcac aggaagtcct tgtaaggctg   1829340
acaagcggac agctgccttc acatagtcag agaagacgaa gaaagttcca ccgtatacac   1829400
gaagtccacc atgaagggcc atcccgttca agattgttcc cattgcaaat tcacgaacac   1829460
caaactgaat gttacgattc aagcgattgg catcgtcttg aagtccatcc gtcttgatat   1829520
aagtcatgtt tgagtgagca aggtcagctg atccacctag aaaggttggt aatttagctg   1829580
ccacaacatt caaggcatct tgacttgaat tacgagttgc ttgagaaaaa ccattttcta   1829640
aagctgggaa gtctgctgga gtcacttcga ctggatcacg tccgtcgatg atggcttcta   1829700
cttctgcagc cagttctgga tgagcttctt tataatctgc aactaattta gtccaagctt   1829760
gataagctga tgcgccacgg tctgcaacat gttctttgaa atcagcatat acttgttctg   1829820
gaatttcaaa tggttcgtag tcccaaccga gggcttgacg agttgatgca gtttcatctg   1829880
ctccaagagg ggcgccgtgt acagcattag ttccttgttt gtttggagaa ccgtatccaa   1829940
taaccgtctt cacttcaatc aaagatggct tgcctgaagc ttttgctgtt tcgatagcag   1830000
catggatggc ttccaagtct gttccatttt caaccaaggc agtatgccaa ccgtaggcat   1830060
tgtaacggtc acgaacactt tctgtaaagg aatcctttgt ctcaccatcc aagttgatat   1830120
catttgaatc ataaagaaca accaacttat caagtttttg caagcctgcg tatgaagctg   1830180
cctcgcttga gacaccttcc atcaagtctc cgtctccaca gataacgtaa gtatagtggt   1830240
caaagatatt gtaaccttca cggttatatt tggctgccaa gaaacgttct gcttgggcaa   1830300
aaccagtagc agttgaaatc ccttgcccta gaggacctgt cgtagcatca atccctgccg   1830360
tatgaccaaa ttctgggtga cctggtgttt ttgaacccca ttgacggaaa ctcttaatct   1830420
catccatgct gacatcttca aaaccagaaa ggtgaagaag agcataaagg agcattgaac   1830480
catgacctgc tgaaagaata aagcggtcgc ggttaatcca gtttggttga gctggattga   1830540
tatgaagttg ttttgtaaag aggctgtaag ccatcggagc cgctcccata accacacctg   1830600
gatgacctga gttggcttta ttaatggcgt caatacctag aaaacgaatt gcattaacag   1830660
atagatttga catagaattt cctttctatt tgaggtgatt attgaatcac acattctatt   1830720
ttactattat atgaaaatta tccgtatcat gcaacatacg gataacctcc aaagaatatt   1830780
tttatattat agcaaagctt taaattgaat gttagagtct tgttcaaaac aatcatcaaa   1830840
accacgtgga tgatggtatt ctactaagtg ttgatcttga ggataagtgt acttaccgcc   1830900
aacttcccag ataaatggat ggaaatcgta ttgcaagcga tcttttcgca ttttccaaag   1830960
ttctagaatc tcattagtag aagccatgaa gttagaccag atatcatagt gaactgggat   1831020
aatgactttg gtacgcagat tttctgccat acgaagaagg tcgatagatg tcattttgtc   1831080
ttggatacct accggatttt caccatagtt attcaaagca acatcaattt taaagtcttt   1831140
accatgtttt gcaaaatagt ttgagaagtg agaatctgca ccatgataga tggttccacc   1831200
tggtgtttca aagatatagt taacagcctt ttgagccatt tcttcatctg taacagccaa   1831260
gccagcaagt tcaccgcctg tctcatcagc accgttcact gggagagtta ccaagcaagt   1831320
acggtcaaat gattctactg catgaatctt catatctttt aattcgatag tgtcacctgg   1831380
tttaacaacg atgatacgtt cttttggaac accccatcct tcccagattc gtccacagtg   1831440
gtaaggaccg ataaacttaa catgctctaa cttaggatta ttgagaattg ctgcagctgt   1831500
gtatgggtcg atatgatcac tgtggaagtg tgaaactaag taatagtcta gttcgttgat   1831560
agcaaatgga tcgataacca ttggctgaac acgcaagttt ggttgcagct tacgaacacc   1831620
tgccatattt gccatttggt gcccacgaac catatctttc acttttttgg ttgattttcc   1831680
acggtttgac caaaggtcca tgacaacgtt agcaccagct ggtgtcttaa tccaagtacc   1831740
acagttgcct agccaccaca tggcaaagtt gccttcaggt acgacttctt cttcgatttc   1831800
ttcgttcaac catgttcccc actctgggaa agtggctaaa atccatgact ctcttgtaat   1831860
ttctttgacg tttggcatat gttgcctcct ttggatataa ttgttatctt tgagattagt   1831920
ataccaccct tcaaaacact aaaaaagacc aagaaaaaca caggtttgtg ttcatcattg   1831980
gactgtcctt caaatatctt ccaaaaaagc ttgaactact atttcttgat ttataagtgt   1832040
ttgaacctct tcttggaact tactagccaa cttgctgtct acaatataag acgaaataag   1832100
actagaaaga ttttcactga aacttttgct cttattacga aatatattgt gtttaagata   1832160
gtctagcatt ttcaaaatat cttctgcttc aaggatagga ttaaccctta aaatcggaaa   1832220
tctgctatcc aaatcatcat tagtagtaat cactacatca acttgtgcaa tatcttccac   1832280
actcttaaat tgttctgttg taaatacagt gtcaatttgc tcatttggaa aataaagttt   1832340
gcattgtttc agcaaaagtc tcgaaaccgc aacaccttca tcacaaacga gataaacttt   1832400
tttcatattt ttttgagatg atggtgtata ttttaaaaat cctccaatat gaatcgtcaa   1832460
ataggcaata tcatcgtctg ttagccgaat aaaccatgct ccttctaaaa tttccgcaga   1832520
ttttctagtg actaaaaata attctccata cttggatcga atttgttttg ttagaggatt   1832580
tttagaaaaa ataccgtaag tctttctaaa taacaaggct ttacagtgga tcatcaaatt   1832640
tcgtaacaaa tcatccttgt tctcaatctc cattcggatt tgtgattcaa aataccagat   1832700
aaattcttct aaagcaagtt ttaattgccg aaaatcatca ctttctgcat gaatatccaa   1832760
atctttacga taggagagga ggagaacagc tacaagagaa acttcaagtc ctgacaaaga   1832820
aatttcaaac ttttgaaaca accgttctcc taatttctta gacacctgat actctattct   1832880
ttttcttatc aaagaaaatt ctttctctat atcctgatgt ctttcttgat actgttcaac   1832940
attatgacag cttaacagca aataaggtag aacctgcaac ataaaagtta tttcatgatg   1833000
gtttattttc ttccctaaat cttgttcaac taaaggaacc tgttccttaa aaaattggtt   1833060
catttcaaca gaaagcaaac actcatcatc taacctctct ttcatcttat cttctaaaat   1833120
agatacaaaa gtggcatttt cttccataaa aatatgatat agaagcgatt gaagatactg   1833180
aattttatta agagggtggg catgaaggtt gtatccctgt gacttgctca cttgcaagat   1833240
cacctgatat tgttccaaag ttagttgata acgaatacta ttcaaatcat tgagaacagt   1833300
attcctagat acctctgtta actctatcaa tttttcaatc gtaatacgtt ctttagaaat   1833360
acctatccat agtaacatta tcatcatacg ttcatgcgca ctcatgatat aatcgtacga   1833420
atctacttcc gataatagtt tacaacaagc atctctctgc tcttccgtta agtgaatacc   1833480
aattcgtgga atactaatga tgtgaagcgc ctcgtcaccc agagcagcat tgattttgtc   1833540
aatgtgataa taaattttcc ttcttgactc tttcaaatct ttcgaaatcg ccataatcgt   1833600
tttggacgtt tcttgatcca tcaaatattg aagcaaatca caacttgcct tatccagtac   1833660
catattaaaa aatcccccaa atctattgat atcacagcaa ttctttttat tttaccatat   1833720
atatatcaag cgctatttct aaaaaatctt ttaaaattac ttcaactcca actttactct   1833780
caataaaaat caaatgtaaa aagaggagct aaatttatct ttttctcctc cttcatcgtt   1833840
cttacttttg accataataa gcatttggtc catgtttacg ttggtagtgt ttttctagta   1833900
tgtactgggg agcaggtcca actcttggat tgatttgttc tgtaaagcga ttcatctttg   1833960
atacttcctc tagtacgaca gagtgataaa cagcattctc tggatttttg ccccaggtga   1834020
atggaccgtg attgcgtaca acaattcctg gtacttcaac cgggttaagt ccgcgatgtt   1834080
caaactcttc tacgataacc aggccagtat ctttttcata ggccacttct acttcgtcct   1834140
tggtcaaact acgggcgcaa gggattgaac cgtagaaata atctgcatgg gttgttccgt   1834200
agaaaggaat atcacgacct gcctgagccc aaccaacagc ttctgtcgaa tgggtgtgaa   1834260
ccacactacc aatttctgac caagtcttat ataattgcac atgagttggg aggtcggaag   1834320
atggtcttaa atccccttct aggatcttac catctagatc agtcactacc atgttttcag   1834380
gtgtcaattc gtcataatcc acgcctgatg gtttgataac aatgacaccg agttcgcgat   1834440
taacttcaga tacattcccc caggtaaatt tgacaagtcc atgttttggc aatgattgat   1834500
tggcatcaca gactcgttta cgcatagcat tgattacttg attcatctta catcaaacct   1834560
gctttcttaa tgagtggata gagaaaagct tgcgcctctt gaatggctgc gcgtgtttct   1834620
tctactgttt cacaattttc agaccacatt tcgattagga aaggtccatt ataattggtt   1834680
tcctttaaaa tatcgaaagc ttcttcccat ttgacacaac cttgcccgaa aggtacatct   1834740
cggaactggc cctttgaact ttctgtcact gcataagtat ccttgagatg gagagctgcg   1834800
atggcatgat gaccaagata aaactcacta tagatatcat tatgccatgc agacacatta   1834860
ccaatatctg gatatacaaa gaggaaggga gagtcaatct ctttttctat agccaaatat   1834920
ttttcgatgc tactgatgaa aggatcatcc ataatttcaa tagcaagtac cacctgagct   1834980
tcttcagccc agtcacaggc ttttctcaaa tttttgataa aacgttggcg tgtctggggt   1835040
gacttttcct catagtaaac atcgtaacca gctaattgaa tcgtacgaac tcccaagtct   1835100
tgagctaatt cgatacattt tttcatgagt tctagagatt tttcctctag aactggatct   1835160
tttgaaccca atgggtagcg acgatggcct gaaaaacaga tagaaggaat acgaacacca   1835220
gtttcataga ttgctttgac aacttccaag cgttcttcct tactccagtc aagtcttgct   1835280
aaacgctcgt cacgttcgtc aatagacatc tcgacaaaat caaagcctaa ctccttggca   1835340
aaatttaaac gttctagcca agtacagtgt gttggggttg ccttttcata aattccaatt   1835400
ggacgtacca tgatttaccc ccaaattcgt ttgatttcat ccttgaaggc acgcgctgct   1835460
cctgctggat ccacagcctc tgtaattcca cgacctgcga taaaggtaaa gacatcaata   1835520
ccttcaaaga gtttgagagt atctacatct agaccacctg ttacagatac acggaagccc   1835580
atgtcaatga gttttttaac cttattaagg tctttttcac cccaagtttc accagcaaga   1835640
agagcatcac gagattggtg ataaatagct tgtgagatac ctgcatctag ccaaagctga   1835700
gcttgttcaa aagtccaatc gccataaagc tcgatctgga tttcgcctcg ttctcctcgt   1835760
tcagtcttga tagcctttag agctgcttcc atagtaggga tggttgcaca acagatacaa   1835820
gtcatccagt ctgctccacg aaccgcatta tttttagcaa ctgttccacc agcatcagca   1835880
cattttgtgt ctgccacaat aatcttatct gggaaaaggc tacgcaagac ttcagccagt   1835940
tcacttccaa cttgaagcaa gcaaacagtt ccagcttcga taatatctac ttcctgacca   1836000
acagaaacag ctgctttaat cgctccttgc aagtctgaat ggtctaatgc aacttgtaaa   1836060
ttaggtattc tttttgtcat ttctttattc ctctttctaa ctttccaaat ccaatccttc   1836120
gagataaggg ctatccttag attcttcaat catagccaag acatcttctt tagtctggca   1836180
agcctgtaaa cgtgcaatag aatcttctaa ttcaaatagg gcaataattt gtggaatggc   1836240
tacacttgtg tgaatttttg aacttgttgc tgctagtgcc aacaaaacag atacctcttt   1836300
cccatctgaa aatacaacag gattttgtaa ggtaatcaat gaaaaggcat cactttgcac   1836360
acctgcttca ggtctagcgt ggggcatagc catacctggc atcaagatat agtaaggccc   1836420
atactcttca gtcgattcaa tgatagcatc gtaatactct ggcaaaattg ccccactttc   1836480
aattaaggga tctactgcta ccttgactgc ttctttccaa ttgttagcct ctaaacctag   1836540
tcggatcgag tcattgtcaa ttaaagcttg ttttaaattc atatctgcct cctttattta   1836600
aagagggaga aggacagaaa cgataactct cagtttctgt ccagccccct ccaacctttt   1836660
actgtagtgc ttgactgagt ttttcggtga tttctttatc atccatcaag ttatcaagcc   1836720
caattaactt cccattagtt cgcccttcca attcttgaat caaatgaaga gaagcgatta   1836780
cgatgtcata tcctactgct aaacctttag cttcaccgac actgcatgaa ttgactgtaa   1836840
aatctgtttg attaagctta cggagagcat tttcaacctt catcttgata accattgatg   1836900
aacccattcc atttccgcac gctgctaata ctttaaccat tttatttctc cttttctaga   1836960
tactaagctt cttcttgaac ttcaccgttg taatatttct ctttatcttt tgctttggca   1837020
aattgaagtt gaggaataac aagcaagaag agacacacaa gtacataacc aacaatacca   1837080
aggtatttga agatatatcc aaatccaagc catgggaatt caaagtcgat atttccatgg   1837140
tagccaccat aagatgccaa atcgagaagg gccacacaaa gagctcctag agcaacttga   1837200
aggacacctg atataaagga aaggataaca gccgctttcc atccgccgcg tttatcagcg   1837260
tagaccgcaa tggctgcatt gtcaaagaac actggtacaa atcctgtaat aataagaatc   1837320
ggatttttaa agacgatgag caaaacaatt gtaatcaatt gaccaatcaa accaaaggta   1837380
aatcctgaca agacagcatt tggagaacca aatccataag aagctgcaac gtcaaccgct   1837440
gggaatgaac ctggcaacaa tttgtttgaa ataccttgga aggcgtttgt caactcagat   1837500
acgaacattc ggacaccttg catcaaaacg aacaagtaaa ctgagaaggt aaaggctgtt   1837560
tggataatgt acataaagaa atcttgttta gcaggattga atagagttcc tgaagtgatg   1837620
acttctttat tagacataat gtctggaccc aagattaaaa gaatggctcc gaagaatacg   1837680
agcatcaagg tagcagatgc aacaactgta tcgtggaaga ttgagaggaa cttaggtaat   1837740
ttaagattgt ctaaactttc ttctttctta ccaaagcgtc ctgctacttt atctacaaac   1837800
cagattgcaa attgctgttg gtgaccaatc gcaaatccgc caccaccagt caagcgttga   1837860
gttgcctcaa cagtcatatt tgaactaact gcccagtaaa gtccacagat gataccaatc   1837920
gctgctgtac cgtaagcatt gcgcaattgt ggtactaaga atagaaccat aagagatact   1837980
gttgcagctt gttgtaccat gatgtgacca gtaataaaga gggttcttac cttcgtaatc   1838040
tttcgaagag ctacgagcaa gatatttatt ccaaaaccaa tcaatagagc tgtagttgca   1838100
gttccaacaa aatctggaaa ctctgctaca attttgttgt ttgctgcagc aagtccaaag   1838160
taagggtcga taaccgctgc accaatttgg aatttgtagt taagagctgc taagattgga   1838220
cgaaaggttg taaccaaacc accagcaccc acgttaagca acatataccc tactgttgct   1838280
ttaacaaacc ctgaaaaaac gtcatgggca ggttttttca aaagtgcata tcctatcaac   1838340
accaataaac ctacgaaaaa tgcgggattc tgcaaaatat tgctagaaaa ccaatttaga   1838400
acacttgaaa cgacttccat aattgttctc cttttgaatt gtttttgtaa gtttattata   1838460
taatgcgaaa gcgcaaacaa aaagaccaag aattacacag cggactgttc actcttggac   1838520
tgtatgattt atgatgtttt acaaattatc ttattttctc gtagctagat aatagggaag   1838580
aattttagaa taagacttca ataagccttc tacgatttct tcttcagacg aattttctgt   1838640
cataggaaca tctaccttca ctaaaacttt tcgaacttct tgacttctca ccttctcgcg   1838700
taaagtacga cgcttttctt cattcgcctc ccaccgttga ctttgaccat tagagtaggt   1838760
tagataataa atccctttaa cggttggaat gtctaaaact ttggcctgct tgcccagtgt   1838820
ttgctcatcc ttcttacgtt cgatgaaact gacttccaaa gaaattccaa agtcagtaga   1838880
tgtcccatac aaacgtaagg ccatcatagg ttctgtcact tgtccgtctc tctgtagata   1838940
aacccaaaaa tgtggtctca aacgctgggc ctgattcatc cactggctag tctgttggag   1839000
ttgccattct ggatggcttg cttgaaaggc tttggccagt tctgtaaaaa cctttcgggc   1839060
ctcttgtcct ttgtggcgga atgccagcat cttctctcgc tctgctcccg ctttatcagg   1839120
attacggtac tgcaaaccag caaagtctaa atagtctctt atcttattca acatcagttt   1839180
aacctcctct aactagcaaa aaatcaggat aaacctgatt ttacttattc tgtatctaca   1839240
acaacatagc gatttggctc atcaccttca gagtaactag tcacgccatc catacgtgaa   1839300
ataatacgat ggataatctt gcgttcgcta tttgacattg gatctgtttt atgactgcgc   1839360
ccttcttcca aaacacgagt cgccaatttt tgcgcatagg tctgcaagac ttctgcacgg   1839420
tgttcgacat aatcattgac attgattgta acgtagaagg ttctggaata gcggttgtaa   1839480
agataatttt gagccaacag ttgcaaggcc ttcaagactt taccatggta gccgataata   1839540
cgacctggtt cgttggtgtc aatttgtaga ttgatgctac gacggttata atcatttgaa   1839600
agtgtagcct caacatccat gtcatcaata atcgtttgaa cataagccat tacttccgta   1839660
gctacttgtt caatatcaaa gttcgtttca actttcaagc ccaagtcttc tagttcttga   1839720
ctttcagctt ggtcttgctc agtttcaagg tcatcagcgc ctgcttcttc cctcatcgct   1839780
tcctcgattt gaagttcatt taaaatctca atgtgaccag tttcttctaa gatagtgctg   1839840
gcatgtcttt catgttttaa gatttcagcc ttgacttcat cagaaatacc ttgaccttct   1839900
tcctctattt ttttaatagc atcaaccaca tgaccaaggt caacggtttc ttcactaacc   1839960
gtcttcacag gctcgttcaa atcattgatt tttttcggaa cgccttttac tacctgttga   1840020
tttgctttga caacagtcgt ttcactaatc gcttcaatat ccacttgggc tggtttttta   1840080
ccaaatagac caagaaagcc ttttttctcc ctagaaatga ctttgatatg agccttcatt   1840140
cttggaatat ctaattcttt caatcctttc tggattgctt cttcaacagt tgaacctgta   1840200
aatactacca ctaccagatt cctccttatt tatttcgttt tctgagcctt tttcttggct   1840260
tttctttttc tattttccaa atctttttgt gcctgtacta cggcctcgcg ctctgcgata   1840320
atcttgaatg gattattcaa gaaataggtt tgcaagactt gataagcatt agacactgtc   1840380
cagtataggg cgactccacc tggcgcataa actgcaaaga taaaaatcaa gactggaatc   1840440
ccatacatca tcgcagtcgt agcgccattt cgctcagaca aagctttgtt ggacaaccaa   1840500
gtacttaaaa aggtgaatac tgctgctaaa atcggaagaa caagggttgt atccacacta   1840560
ccaaggttaa tccataagaa atgacctgtc tttaaaaagt caactcttga tagggcttgg   1840620
aacagggcca aaataaccgg catctgaatc aaaatcggcc aaagagagtc tgactgtctg   1840680
acacccattt ctttaaatac tttacgcatt tcctgctcta gtttggttct gctttccata   1840740
tctcgacctg gatattgttc tcgaagcgcc ttaatgcgtg gctgagcttc ctgcattttc   1840800
ctagaagcca ccatttgcac ctgaaagact ggcaagagga ctgtacgaat caagaccgta   1840860
aagagaataa tccccactcc gatactaata tcaaacgata aaaagcgaat gatttccgca   1840920
aagaagtaaa ccaatttact ccaaaaatca gccgattcgg ctgtaatatc gctagttacc   1840980
ccattagtcg cacaggctgt catgattaac agagacagtc ctagcaaact agtcaacttt   1841040
agtttctttt tcactcccat ttccttcccg gtaaatcttt gataatttta atacatggag   1841100
tagatttttc tccatctctg cgtatcccaa ggtttcgact ccttttcgag caatgacaac   1841160
aaagtcgaca tcttctacca gactcccttt tgcattctgg ataatatgcc gaatccgtcg   1841220
cttaatttga tttctagtga cggcattccc cagttttttg ctaactgata gacctactcg   1841280
aaaacggttt ttctggtttt ctaattggta gaccacaaat ttgcgattag caaaacttgt   1841340
cccctccttg aaaatcgcct taaaatcttt ctctcttttt acacgaaagt ttttcttcaa   1841400
aactcaactc catctattaa attactacta ttataccata tttttcaaaa aagccaatca   1841460
tagcaaggtt ttggacaatt tcatcagaaa aagaagctgg aaaaataact ttcccaactc   1841520
cttgtattga atattttttt agtttcactt attttttcaa gcgttcaacg tcacgggcaa   1841580
tgactaattc ttcatctgtt ggaataacca agacacggat tttagctgcc tctgttgaga   1841640
tgtctcctgt aacgccaaag acattctttt catcatcaac atcacaacca aaccacgaaa   1841700
tccctgagat tacatcacga cggaaactct ctgcattttc accgacacct gctgtgaaaa   1841760
caatggcatc tgctccattt agcactgcaa ggtactgacc gatatgtttt tggatacggt   1841820
caacatacat ttcataagcc aagctagcct cgtgattccc ttctgctaca gctgcttcta   1841880
tatcgcgcat atcgctagaa ttagcagaaa ctcccaaaag acctgattca cggttaagaa   1841940
cacgactgat atcttctggt gtgttaaaat cctctgtata ttgcattaaa taaggaatga   1842000
tagctggatc aatatcccct gtacgcgttc ccatcataat accaccaaga ggagtgaacc   1842060
ccatagaagt gtctacagat ttgccggctt tcacagctgt aattgagcct ccgttaccaa   1842120
tatgacaggt aattaacttc aagtcttcta atggacgtcc caagagtttt gcagcttctc   1842180
ctgctacaaa ctggtgactt gtaccatgag caccgtattt acgaaccttg ttttctgtgt   1842240
aatattttgt tggtagaggg tagcgataag ctttctctgg catacttgtg tggaaggaag   1842300
tatcaaaaac aactacactg gtaatgtctg gcaacaattc cttgaaggca cgaacacctg   1842360
ctgcattggc cgggttgtgt agaggagcca acaaactcaa ctcttcaact ttttctaaaa   1842420
catctccctc aacaactgtt gattctttga aatattctcc accagcaaca acacgatgtc   1842480
caacacctgt aatctcgtca taagccttga taatatcgaa acgaatcaag tcatccaata   1842540
aaattttaac ggcttgtata tgattttcaa tatccaaaat ttgttgttca gaacggccgt   1842600
caaattttac agttgaaatt gaatctttca aaccgatacg ttcaatcaaa cctttcgcca   1842660
atactttttc ttctggcatt aagtataatt gccatttcaa acttgaactt cctgcattga   1842720
ttgcaattgt ttttgtcata acatgatacc cctttttaag cgttttcaac tattataaca   1842780
aaatctattt tatatttcag taccttgagt ccatttttga aaattttctt taaatttcat   1842840
taaaacactt gcatcttgca agctagcaag tggataaaca aaaggctcta ctgctatttc   1842900
atttttcttc tgtaagataa aaatagtctt agattgtttg gcattagcaa agagattttc   1842960
aggcagacta atcatagcaa ccagactcgc ctcttctttc agccattctt ttaacaaatc   1843020
actttgagga ctggtcaaca aatcactcgg agctagaaaa atagcgtatc cgtctgactt   1843080
gaggtactta agcccttgtt ccatgagcaa gtgatgggcg taagtatgtt cttggctaga   1843140
agcaacttga tggcgcgacg caacggcatc atcaggataa tagccgacag gcaagtcact   1843200
gatgaccaca tcgctttctt tgagcatttg tgggcgaacg gcatctcctt ggacaaagcc   1843260
agcctgcaaa ccaattacat ctgccatgct agctgccaga tcaatcagca aatcatccac   1843320
ttccattccc aagtaatcca cctttttagt aagcgaggtc aagaaaatag cgcctagaat   1843380
tcccatccca gaacccattt cgaggatagt aatttcctcc tctttaaaca actcttccac   1843440
aataaacacc aaaagcaaag caatagcatc cggtgtaaac tggtgattgg cctgcaaggg   1843500
ttctgtttgc ccagccttca tcaagagaaa ctggtaggtc ttgagccatt cttctttgcg   1843560
tagtgctaaa cgcttaaggg tttgattgtt ctccttgacc tggtttagct cagtttcacc   1843620
atccagatag atgctatttt gctccaccaa ggcgtcataa aagttggtcg ccaaatcact   1843680
ttggatgact tggacattct ctagtaaata ggtataagct tgttcaattt tttcaaaatc   1843740
catattccta tcttaccaaa tttcccttct tttttccatc cttatagaaa aatcactccc   1843800
tgactaggcg agtgattttt gggctactat taaaaagaat tctgagtgat ttccttgaaa   1843860
caggtcttca gcactataga gaatctgact atgcacagat gaaaaaccat gctcaattag   1843920
cttgttttcc agttcagcta aatcaaatcc atgatgatta gcttctgtct tggtaaaatc   1843980
agcaatgatg agtttcccat cttccttcaa atgttgatga aacagtgaga gagccgcatc   1844040
caaatcaggc atatgatgaa gaacccgact aacagcaagg caatcaaact ctttctccaa   1844100
gggatttttc ggtaaatctt gctccaaaaa ctggatattc ttgattgctt gctgctccac   1844160
tttcaaacga gcttgctcca acattttctc agaaatgtct acaagagtga ctgacttagc   1844220
ctgcttggct aggggttagg ggcaaggcta atagacccgt gccaccaccg aaatctaaaa   1844280
tttctttgtc tgatagaaga tcaatctgtt tctcggctgc ttgacatacc aagtttgcga   1844340
ggaagatatt tttaggggaa tcgaaagttt ctgctttgtg gttaaaatca tgtttcatat   1844400
ctttaattta gcacaaagta tagtaaactg aaataagata taaacaaatg aattggagct   1844460
taacatccat ttccagcaat tttctagaaa ctacagtgga ctattctgga ttcaacgcat   1844520
tatagttgaa ttgactatga attctctttc ttttcaggct tctcttctga ttttttcttc   1844580
tccacttttt cgcttgaatc ggtcgctacc tcttcctttt tatctctttt ctcttctttg   1844640
attttgactg aaggaaacag aaactcatat tggctcttat ccgtacgaac cctcgtcact   1844700
aagccagttt tcttgttttg atagcttacc tgacctagat taaaaaactg ttccccactt   1844760
tcttgctcaa ccttatcttt ggttcgttta gccatagcaa aagcaaccaa tttttcttta   1844820
ttcaaagcat agtcttgata gtgggcgact tgtcggttca aataaaattg caacaaaaga   1844880
ctaaagatgg ctgctatggt gactgcgtag aggagaacac ctgccttaac ttttttcttt   1844940
ttccacacga tagatgaact ccctttctaa gcctttttgg aactggaaat gaaagcgaac   1845000
cagttgattg tcctctgtaa tccgtacaga tttgagtcca taaaccatag gctgataacc   1845060
tcgaccacga gcattcgttt tacggaaatc atctgacttt gacttaccga tggcgatgtc   1845120
cttgccatct tgcttcatgt ataggcgatt gccttctact ttttcgaact gcgaacggtc   1845180
taattctacc tcaagttggt ccacaaacaa gagccactcc ttttgctcgc tttgttgctg   1845240
gtagcgaact tctgaaatga ggagctgact catagcttga aaaaggagta atcccccact   1845300
gatgacaatg agggcaagca gggattctaa caaggtaaaa gccttgacct tatggctctt   1845360
tgattgccaa caactgttct gaaccatggt agacctccaa tcctttttca ctagaaaata   1845420
cctgaatctc aactccgttg atgcttacct gattttgccc cgtctgcagg gccatcttag   1845480
ctaccctcaa gacttcttcc ttttgcaaga tttttgcttc ctcttgccta tttttttgaa   1845540
tttgtcccaa aaggagggtc gcaatgctgg caaagatagc tagagcgact actgcttcca   1845600
gtaaaatcac tgccctaatt ttttgtttcc ttaatgcgtt taatttttcc atttcctaga   1845660
tataattgat agcgaatcgc tcctttactg gtctgaaatt caaccttagc cagggacgaa   1845720
ttgcccccag ctcggtcaaa tgtaatactt tggcctgatg gggcctgaat tcctttaggg   1845780
actggcaact tttgactgcc attgctaagc gtctgcccat ctaagttcag actagtcttt   1845840
tgctgactgg ctacactgcg tttttgggtt tcccgataga gttcttcaaa ctccataaag   1845900
aaaatctgtt cctctaccgc tgaaaaagtg gactggacag agccggacaa gcccaaggca   1845960
aggatactca caagtcccaa aaccaagaga ctttccagca tggtaaaggc cttaatcatt   1846020
gactttacga tttgctcctc catttttatc attgtattct ttataagctt tagcctgttc   1846080
ttccgtgatg cgtccatctg cttgtaactt tcttaggcta gcatcttcat tcttttctaa   1846140
gctataaagt tctgcctggc tttccaccac cttaacaaca gctgcttttc ctttgtcatt   1846200
gactgcttct ttttgcttgg tcagattagg tacaaagagc aagaaaagca cgctgataat   1846260
cagcaagacc accaacatct ccaccaatgt aaaagcttta accttagctt ttttcaagaa   1846320
tgtcatcatt tttttcattt taaaaattta cctccatatt ttgatacatg ggcatgagca   1846380
ttgccgcata aagtaaaacg ataatcagtg ccacaaagat aaaaaccagt ggctgcacca   1846440
aattcatggt gcggttgact cgggtaaaaa aggcttccca agttttttca gcatagattt   1846500
ccaactcact acccagcttg gacttaactt ccccatactc tatgatgaga ctcaattcct   1846560
tcctaaagaa aggataggtt cctatcgtct gagaaaattc acggccattt ttcagggttt   1846620
gagccagatc ttgaccgact tctttaaaga gctgggaacc ttgttcctgc atcatttgaa   1846680
aaatctgcgt caactccatt ccctgtgaaa tcatattccc ccattcacgt gcataatagg   1846740
ctgtcaagta ggtctgcaca aagattccaa taaagggaag gcgtgctaag atagaaaaga   1846800
cactcatctt agaacttctt ttataaaaag tgagtgctaa aagggcaagc acggaaacaa   1846860
gccctaccat gcctagaaaa atttggggca gattaccgat aatttgggtg gcaatattgc   1846920
tactatccag ttgtgggagc aggtaattcc gtagccccag cataattaag agaagaaaac   1846980
ccagcaaaat caagggatag gtcgctactt caatcaattt tttcttgacc ttagccagat   1847040
tgtccagata ttcttctatc tttcccaaac tcaggtggag attgccatga acttcagcta   1847100
gggataactg agtgacaata gcacttgaac atcccaaact ttccatcatt tctgagaatg   1847160
atttcccctg agacaagccc acacgcatct gggtcacaca ctgcttgtcc aacaaagcac   1847220
tcctatctaa aaaggagata gtctccacca gatgaaaacc gctagaaaag agattgttaa   1847280
atagggtgat gatatttttt tgcttagctg tagctaattt tttccgtctc agcctgaaga   1847340
cttgtgatat gtccatcttt aagaagctgg tcaatttgct cattccactt ggctgcttgg   1847400
tgttcttgat aatctctgct tgcaaagtca acgattcctc ctcccccgat taatctctgg   1847460
tagcagactc cttgcagaac aactgccaat tcttcttcac tcacacccaa ctccagcaga   1847520
cgctcataaa cacctcggat actcttggcg tgaatggttg aaaagactgt cgcacctgtc   1847580
aaactagctc tgaccactgc acgcgccgtc tcgctgtcac gaatttctcc gataatcaag   1847640
agatctggtc gatgacgcaa ggaaagtttg attagatttt cataggttag gccgattgct   1847700
tcgttcaact gcaactgaag catgtcgtcc tgcttgattt cgacaggatc ttcgatggac   1847760
ataacttgct gtcctttaaa gagtgacttg gacaattcat gcatcaaggt cgtcttacca   1847820
ctcccaaccg gaccagcaaa aagatagagt ccccgttgcc tgtactgctt gcctaattct   1847880
tcaatatcct gaaaccaaaa atgcaggtcc tgctcctcat cgtgcaacaa acggataacc   1847940
aaactctcat gcccccgata atcgcctaca gtagataaac gtagagacgc tatcttatgg   1848000
tcataggcat aatcacagga acccagttga ctacgtcttt tttctcccac attcataccc   1848060
gccacaaact taaagtgact gataacggct gcaaactttt caaaatcata gctaccaatt   1848120
ttacagcgct cgtctcctac cctcatatga agctcatagg cgtctaactt agggacaaaa   1848180
tagatatcct gcgtcccttt tttccgagct gaacgaatga tttcttgtgc aatttcttga   1848240
accatactta cctcctcacc tatactattc gcaaagagtt agaaaaataa aaaaagcaac   1848300
tccaaaaaag ttacttttct ctattttaat ttcatacggc aagaacgatt cctttcctga   1848360
ctggtttgtt tttcatagcc tgagcgtagt ttttcgtctg ggataacctg ctcatcctgc   1848420
aaaagagcca aagaatggta ttgttgtaaa tactcatcac attcatcaca ccagcgttgg   1848480
tcttccgggt cccaaaaaat ggtcatcaag tcgcttctac ttttataaag aggcgattct   1848540
tgttccaatc taaaccagca agttttgtag tatttgagag catcataata ctggtcaaat   1848600
tttctacttg ctacaatatc ttcttcccaa ccttctaaga accaccacgg ttcaaaatct   1848660
ccgtacattt ctataacacg atacatattc attcattcct ttgtaccgta tattataacc   1848720
aattccgcca gacaaggaaa gaaatatgct catttcttaa ttttttgata aaaaatccag   1848780
ccatctgatg gatgactgaa tttctattta cttatgtaca aaaatatttt tactacttag   1848840
gcttctgaga tatcgttttc gataatgacc ttaatggcat ggtggtctgc tgccttactg   1848900
aagacttcgt aggctttttc aatttcactg agtttgaaat agtgagttac caatttttcc   1848960
ggttcaatct tatgactttc aagtgctttc aacaattgtg gagtcgtatt tgtagatacc   1849020
aaaccagttg ttacattgat gttgcgaatc caaagtttat ctaaatcgaa ttcaactggt   1849080
ttaccatgca caccacagtt ggcaaccgtt ccgtctacac cgataatctt ttgacagaaa   1849140
tcaaatgttg caggaatacc aacagcttcg atagcgacat ccacaccacg accatctgtc   1849200
aaatcataaa tttctttaat ggctttttca gggtctgaag aattaacctt atgagtcgca   1849260
ccgaatgata gggcagtttc caagcggtta tcgtctaggt ctaccataat caatttagct   1849320
ggtgaataga attgggctgt taaaagagca gccaatccaa ctggacctga accaataatg   1849380
gctacgctgc aaccaggttc tactttccct tttaagacac caatttcata tccagtaggc   1849440
agaatgtctg acagcataac caaagcttca tctgacaagt cttctggagt atggtaaaga   1849500
gtattatctg catgagggac acgtagatat tcagcctgca taccatcaat caagtgaccg   1849560
aaaatccagc ccccttcgtc ttcacagtga gcataaattc cttttttaca gtagtagcat   1849620
ttaccacagg cacagacgca agaaatcaag accttgtcac cttttttgaa gttggaaact   1849680
ccttccccaa cttcttcaac aatcccaatc ccttcgtggc caagaatggt accactttgg   1849740
caagtaggaa catccccttt gataatatgg aggtctgttc cacaaatagt ggtttttaca   1849800
atacgcacaa tagcgtctgt tggcttgcga ataactggtt tgtctacatc aacaaaagaa   1849860
gcaagtcctg gtttaacata agtataggct ttcataaagc actcctccgt ttttttattt   1849920
gtaatattta tagttcaatt gtaagccttt ttctttgttt cttcaagctt tttttgtgat   1849980
ttttttaact ttttatttac cagtaaagta ccctgcataa aaaagcagaa gttagtctct   1850040
aacttctgct ttctctctta tgcttgataa cgttttacgc catctaggta ggttgctacc   1850100
aattccaaat ctttatctaa tacgatgaag tcagcgtcgt agccttcacg gatttggcca   1850160
cagacgtcat cgatgtgaac ggatttagct gggttgaagc tggccatcat gactgcttca   1850220
tgcggattcg caattcccca ttcgaccaca ttcttcaaac catctttgag tttgaggata   1850280
gaacctgcca agttacctgt cgatttgagg cgtgcagttc catttgcaac gacaactggg   1850340
aattctccca acatataatc tccgtcttcc aatcccccag ctgtcataca gtctgtgata   1850400
agagcgatgt tttctgttcc tttttgtttg ataagaattt cgcaagcctt tggatctacg   1850460
tggtgaccat cacagatcaa ctctgcatag gtatgtggca attggtacat ggctccaacc   1850520
atccccaatt cacggtgagt caacccacgc attccattgt aggcatgcac ccaaacactc   1850580
gctccagcat cgattgcttt tttggcttca tcaaaagtcg cgtttgaatg tccaagagca   1850640
accgtcacac cttcgcccgt aactgtacga acaaagtctt ccaccccatc acgttctggt   1850700
gcaagggcaa ttttattaag caagccattt gccgcttttt gccaagaatg aaactcctca   1850760
acacccgggt ctctcatata agttggattt tgtgccccct taaaagtttc tgtgaaatat   1850820
ggaccttcat aataaatccc acgaatctta gcacctgttg cttctttata atggtttcca   1850880
agattttcag tgactgcaag caattgctca taagtggctg ttaaagttgt gggtaagaaa   1850940
ctggtaacac cggtactaag aagtccttca ctcatagtat gcaatgtacc ttcaatgttg   1851000
ttgtccatca catctacacc tgcatatcca tgaatatgag tatccacaag acctggggca   1851060
atgctataac ctgtatagtc aatcacctca gccccttcag gaatctgctc tacatgtttc   1851120
ccaaacttgc cgtccacaag ttccaagtaa ccacctcgac gaactccgtg tgggtagaaa   1851180
aactgatccg ctttaatata gttaggcata atgttaacct ccttaaaaga ttgattctac   1851240
aatttattat gtcaattaca ttataaacct ttctttttta tttgtaaatg gtatagacct   1851300
attttttgga gatattttaa aagagctgga tttctccaac tcttctcttt tttaatacaa   1851360
gttattttga tttaaccggc ttgtcttgag ctgtctgcaa agctgtggca atcgtatctg   1851420
catacaattt tgctcctgct tcgatagtgc tactctcact cccgaaatga acctggtctg   1851480
ttccagccca aatttctgga tgctctttcg caacttgatt ccaatctgct atcgtaatgt   1851540
aaggtgtctt ctctgccaat tctctcatat aggcagcagc cttctcaacg atggcatagg   1851600
tctcttttgt cttatctccc tcataaggag tcaccaaaat catatggtgt cccttaggaa   1851660
gatttttcac gatactgtcc cagtcatcct tgtaattctc aggattattt accccagtcg   1851720
caatgaccac cgtcttaggt aaaaatttat tctggctatt atttagcatg atttcatttg   1851780
cggtcttggt tgttacgctg acctgcgcgt taatctgtgc tccaggaaga gctgtctgta   1851840
gtgctgtatt tgcccttaaa gccactgagt caccaattaa catagtgcca tcagcaattc   1851900
ccaaactgtt tgcatctgcc cgttctgcca tcaccttggt ctggccaata tttgttgcag   1851960
cttgcttcaa gccattgaca gtcaagtctg tctcaaacgc tcccacttgt ggtgccaaca   1852020
aggtcaccgt gcagacaatg atggtcaaga ttcctgtacc tgctgcaaga attgcgtgaa   1852080
tataaggcag gggacgaagg gtttggacaa taggtgtgtt cttgcctgca atccaaggtt   1852140
ccaatacata aaatgacaga ctggcaaagc cataagaaca aatcagagtc agtaatacag   1852200
caagaagatt tgatgtcaac tgtgagaaaa tgatatagaa aggccaatgg aaaagataaa   1852260
ccgcatagct agtatccgct aaaaagctga taatcttcga ctcctgtata tgatgtgtct   1852320
tttcatgtaa gacacgcgcc gccagaatca tggcaagagc tgcaagactg gcaagtaaga   1852380
agccgataag ataggcaaaa agataagtga atttgacaaa gaaagtcaaa agaactagga   1852440
aaccaaagcc tcctccaaaa actaccaaag tctttcgtaa atcccagatt ttatccaact   1852500
gcttgacgag ggaagtcgtc tgacgaacgc ctacaatagt tgctaacata cttcctaaaa   1852560
agaatggata gacatgagtt aaactggaga aataaacaga ggaataagag gtcactagaa   1852620
aactaccaat aaacatggag aagaaactga tcaagaaggc aacagcagat aagagaaaga   1852680
ccatcccctt caactgacca tttgatttag cttgtttgga taagaaccaa actgccaatc   1852740
cccaaagaat atagtagtga acctcaactg ccaaactcca attatgaaca aacaaatgag   1852800
gaatgaactg agattcataa ctcccacctg ttaggagttc atagaagttg gtcataaagc   1852860
ctaagacgcc cgcaatctgg ccaccaattc cagcaacata gtcttggcga accaagaaag   1852920
taaaaggcat ggtcaccaag accatcaaaa ccacaggtgg cacaatccga taaaagcgtc   1852980
ttctaaaaaa tcctatcaaa tcaatctcat tgttcttaga aaattcttca atgagtagag   1853040
ctgtaatcag gaaacctgaa aatgtgaaaa agacatctac cccgaaaaat cctccaggaa   1853100
agatcgtctg aaagaagtga tacaagagta ccaaaagtaa acctataatc ctaatcaagg   1853160
aaaaccattt aatgcgcata cgagtttatt cttcctttca ttgtacactt tattctatca   1853220
aaaaaagaag aaaaatccta agagaaaact taggattttt ttatatcaat tccattttag   1853280
aaattacgtc ctgacttatt atagccatat ttttccacaa aatactcacg gaattccaag   1853340
agattgtcat ccatgatggc ttgtcgcact tgcttcatca ggttaagcaa gaagtaaaga   1853400
ttgtggtagc tagtcaagcg gataccaaag gtttcatcag ccttgagcag gtgacgaagg   1853460
taagcgcgtg tatagttatt acatgtgtag caatcacact caggatccag tggcgtaaag   1853520
tcctcagcaa actgggcatt tttcacaacc aaacgtcctt gactggtcat acaagtcccg   1853580
ttacgagcaa ttcgagtcgg taagacacag tcaaacatat ccaccccacg aatgacccca   1853640
tcgatcaagc tatctggcgc tcccacaccc atcagataac gaggtttatt ttcaggcagc   1853700
agttgagttg taaagtccaa gaccgcattc atctcttcat gggtttctcc cactgccaaa   1853760
ccaccgatag agtagcctga gaaatccatg ctgacaagat catgagctga ttggcggcga   1853820
aggtcttcaa atcctgcacc ttgcacaatt ccaaacaaac cttggtcatg tggacgacgg   1853880
tgagccttca aaccacgctc agcccaacgg ctggtacgct cgatcgattt cttaacgtag   1853940
tcataaggtt gataaaactg aggacattca tcaaaggaca tcatgatgtc tgaacccaga   1854000
ttattctgaa tagagatggc tttttctggg gataggaaca tcttagaacc atttagatga   1854060
tttttaaagg ttactccttc ttctgtgata ttacggctat ctgctaaaga ataaacctga   1854120
aaaccaccac tatctgtcaa gataggctgg tcccaattca tgaacttgtg gagaccacca   1854180
gcgcgtgcaa tgagttcatc tccagggcga agccagagat gataggtgtt tgataggata   1854240
attcccgaac ccatctcctt caattcttca ggtgactgag ttttgacagt ggcttgtgtc   1854300
ccaactggca taaacatagg tgtcggaaag gtaccgtggg gagtgatgat ttctcccaga   1854360
cgagctcctg tgtgtttttc tttcttaatc aaacgatatt tgattggtga atctgacatt   1854420
ttttacctcc gaagctggga aagacagtcc cagttcatac agtgtgccca aggacacact   1854480
gtatgatttt atcaaaaaaa gtaggaactg tcacgaacta tgtataagaa ctatggtata   1854540
ataagagaat gaactatcca aaaattgatt taaaaacaat tcgtcaggag tcaaaacatt   1854600
ttcaggctga caccccccgt ctctttctcc tctatatcct tcccagtatg ctggtcatct   1854660
tatctggttt tcttaatccc ttatctcgga tccacgggac tgttttagaa cagccatttt   1854720
tcagcatact tggccaaata cttcaaacct acctctttcc tctactagtc tcctttatcg   1854780
ggactattct tttgaccagt tccgtctatg caacactgac actcatgaaa gattctaaaa   1854840
cggagccatc tgtaaaaaac agcctagctc tctttgatga ggagcgcttt tctcaaacct   1854900
ttttgaccct acttctcaaa cgtttctatc tctttttatg gagtatccct aatttacttg   1854960
ggatttacct cctcttttat agtagctttt tagccaaaaa attcgtcacc ctacatcctg   1855020
agtttccaaa tctagatctc tcatcagttg aaaccgagcg tttcctcatg gtctttggac   1855080
tctactttct tgcaagtctc atcttgatca ttgtaggaaa tatcctctat attccacagt   1855140
attatgccta ttcacaggtg gaatttcttc tctgttatag tctagaccta ggacaggtcc   1855200
caccaagacg aatcctaaaa actagccgtt cctttatgaa gggctacaag ttccagcact   1855260
ttgtcctaga tttacagctt cttccttggt acttcctcaa ttggattacc tttggcattg   1855320
ctagtttttc actcctacct tatatccaat gcactaaaat tatgttttac cgagcagtat   1855380
tggcccgaaa acgtccaaaa gcttgaaggt ttttcccctc aagctttttt ctatcaatga   1855440
gtttctccgc ctaccaactt gagttcctga tctccatgtt ctattatagc gccgattgct   1855500
gcttctatcc ctcgccgaat atccactaaa ctcatagctg gagtagtcgg tctgttcacc   1855560
acctgttcca tcatataagg aatatgcata aaacctgcct taacatatgg agatttcttt   1855620
tctaccaaat agagagcctg atacatcaaa tggctgcaga caaaagtccc tgccgtattg   1855680
gaaacagagg ccggtaagcc ctcttttttt atagcttgaa ccatcgcttt aatcggcaaa   1855740
ctactaaagt aggccgaagc accatctggg cgaatgggac ggtcaatcgg ttgattatct   1855800
tcgttatcag aaatgcatgc atcgtcttga ttaatggtca ctcgttcagg tgtcaaacta   1855860
gttcttccac cagcttgccc aatacaaagg acaaagtcag gttgataacg attcatctct   1855920
tcttccaata cttgagcaga tttgtgaaaa actgtcggca cctctagcca acggacctca   1855980
gcaccatgga tttcagctgg taaaccttta atggcctcca aagctggatt gcccttttcc   1856040
cctccaaagg gctcaaaacc tgtcactaat actttcattt ctaactcctc aaaaccaatt   1856100
caatgagact tttttcttaa aaacaagtat aacatatttc ccttattctg gattaaaaag   1856160
gattagcgag attagaatcg accttcaagt gtatttaaag agtaaaatac taatcaaggc   1856220
caaaatagct gatccacctt gtttcaaaat aattttttta tccgctgtta aagagccgta   1856280
agtcgcagca ccaatcacaa ataagacaaa aatagtcaca atttctaaat tctgtgagaa   1856340
ataaatgaca tacaagagaa agactcctag cagagcctta taaattcctt gatttttgaa   1856400
caatgaactt actgacggat gagccaattc ttccttttcc atattaaata cacgactagt   1856460
cgcatctgat tgcgtggcaa tactttccaa ataaaaaatg taaaaatgct ccaaagcaac   1856520
gatcgttgtt aaaataattg acatctattt ctccttaaat ttctatattt tcaataccca   1856580
aaaccaattt atttaataaa cggctgagtt ctgttctctc aaactctgtt aagatacttt   1856640
ctatctcttc cttaaccctg atatgttgca gagggggatt caccactaac tgctccttgg   1856700
catacttcgc agcctctacc aacacttccc gctgattttc aggattacga tgacgctcca   1856760
ccaaaccttc cgtttccaaa attttgaaat gccgtgtcaa agcagcctga tcaattttca   1856820
aacgctcctg aaccgccatt tggttacaag gagaatgctc cagcaaaaac agtaaaatct   1856880
gataccgtgt caaactaatc ccaagccttt tttcaaacaa ttgcgtactc gcttgctcag   1856940
acaagcggag ttgatacagt aaatcttgaa tctctagcat ttcttcccct ctctttttat   1857000
tgatttatca atatttgact aattaattgt gatataaagt aaaatagatt gcaagaatgt   1857060
tgcttaactc attacaagat gataactttc cattttccat tcaaattgat actcaatgaa   1857120
aatcaaaaag caaactagga agctagtcgc aggttgctca aagcacagct ttgaagtttc   1857180
agataaaact gacgtggttt gaagagattt tcgaagagta tgacaaagaa aaaacgaacg   1857240
agaatcgctt tccatcacga aagctagatc tcattcgtca aaatgatgtt atcaagtcgg   1857300
gtttatccat tcattgaaac gtgaacgtga tcatagtgat tttctgtcac actaccacgg   1857360
tctggcattg ggttccaagt gttagctggc ccatatttgc tatcgaatgg agcatagaaa   1857420
cgttgtttcc agatgatgta actaatgcca cggctggcca tattttgaat agcatattcc   1857480
gcaatcttat cccctaattc tgaacgttct ggtaccataa agtcgatagc caaacctttt   1857540
ccgtgatctc cactgtctcc tggacgataa ccactaaagg atgtaatgcc aaacaagtta   1857600
gcaatttctt ctttaaaggc agctgtttgt ggttgaagac ctgcattttc agattttgct   1857660
actgcaagtc cagcataatc gggcgcagct ggagcctcgt aagttgttga aattattttc   1857720
gtctcttctg gttgataagt agaaactgct gctgtagctc catttgatga tgctacttct   1857780
tttgcttctg aacttgttgt agttacttcc actgctgatg cagcttgagg gcttgcttgt   1857840
gtttcctgct tctcagctgg agtcgtttcc tgaggagttg cttcttcaac tgggcgagtt   1857900
gtttcggtcg tttgctcctc tgggacagaa gtgcccgtag atggtgccac ttcttcagaa   1857960
gcaatcactg tctttgtaac ttctgcaatt ggttgagaaa ggtctgcaac ctgaacagtt   1858020
tgatcatcaa cggtcacttg attagtggtc aaatctgctg tcgcagttgt cacttcttca   1858080
ctagagtctg cttgaggtgt ttggatttca acttctgtta cttcttctgc ttcattgaca   1858140
gtcgttgtca aaacagtttc tgggaaaatc aagtccatat tagtgatttt gttcagattc   1858200
gcaagcactg tgacatctac acccaaggct tctgcaatgg tgctcaaagt atcaccatac   1858260
tgtacggtat aacttgtttt gttgtccgtt ttagtcaaat cgttttggat ttgctcaaca   1858320
ctacgtgcag tccaaagaac ttcttctgct tgagttgcca atactggggc aaatgacaag   1858380
gctactgttg acgctaataa cattcttttc ttcattcttt caaattcctt tcaaatgagt   1858440
acctgtctat cataacacaa aaaatgtaga aaaaaagccc tctcgggcct atttaacaga   1858500
actgtctatt ccttgtaaca aactaggtta cttgaaatag tttgttaggt ctctgtcaca   1858560
aaactgacac aatcttttta tcacttagtc tcaaaaatac gggaaatatc tgctaacgct   1858620
tgaatcctgt gattcccttc ataagtagac tctaaaaagt tgatgctttg aatcccacta   1858680
ttctgggcaa attccacatc cagagtccga tcccctatat aataagtatt atcagaattc   1858740
aactgatact tatctagcag ataggtagcc gcttctggac ttggcttccg cacaaagcca   1858800
ctctgactgg ttaaaatctc tgtaaaatag gattccaccc ccaagtcctt gagaatggta   1858860
aaagcgttgt tccccttatg agtatatata aactgctgaa ttcctgattc gtctgcccaa   1858920
gctagcacct cacgcgcacc tggcatcaaa actacctgag cattcttctc agccagactc   1858980
tgggcacgca cctgatttag cacctcaaca tccagatttc tatcttctgc cacccgcaca   1859040
agcaaatctt gcaccgaata cttgaagata aactctctca ccttctcctt atcataagga   1859100
atagaaaact gagcaaaagt ctcctcaatc cctgataaaa tcgcttcgta agagtccaat   1859160
aaagtcccgt ctaaatccca aataaaagct gttttttgca tttcctatcc tttcaagctc   1859220
atatagcgct ggtaacgata gcgtagaaat aaccagcgaa aaccattatc caagagagac   1859280
cctgcccaaa taccaggcaa gccccaacca agcacaatcc ccatcagata tcctgtccca   1859340
atgcggatac accacattcc tatacttgtc gcataaaaag ggaggcgtgc atttcctaat   1859400
ccctgccaga ctgccgtata gatgactgtt cctgtcgtca taggggtccc aagtagtgaa   1859460
aacagtgtca ctagaacact agcctccacc gctagagaat cagtcgtata gagatgagtt   1859520
aatggtacac ccaagacata tatactaaag gacaggggca acatgaggaa cagagaaagc   1859580
caaaaggttt gtttactcaa actagcaact cttttccaat catcctctcc aactgctcgg   1859640
gccaacagca tgaccgttgc cgtagcgacg ccaaaggcag gcatatagtt aaactgggtc   1859700
aagacttctc cgattgcatt cccagcaact gcctccgtcc caaaagaaac gaccaaggca   1859760
atgatcacta catctccagc cctcatcata agtcgctctc cagctgctgg taaagccaag   1859820
gtcaacagtt ccttatctaa accaaaagtt ggcttcccat aaggcagttt taattgtgac   1859880
cacaaaatca caagaccaac caaacgagac acaattgtcc cccaagcaac accagctatc   1859940
cccatatcca gaacaaaaat agctagactt gaaaaaagaa tattcaaggc attggataaa   1860000
aaactaacat agagaggcag acgtggatta tgcgttgcac gaatcaaggc tcctagacta   1860060
gtcattaaac ctaagagaac aatcgatccg cctaccaaag atagatacag tccaccactc   1860120
tcagctacat ccctctccgt ccccaaaagt cctatcatct ctttcccagc gaagatggac   1860180
aaaaatccta aaaggaaact taatagtaag gtaatcttca acgcctcagt cacatgatag   1860240
gccaacttcg actggtcttt ctgccctatg ctttttgaaa taacactgga aatagcagct   1860300
cccagagcga tgaaaatcgc ctgataaatg gtgataatat taccagctac tgaaacccct   1860360
gaaatagcta tcaatcctaa atgagcaacc aaataactgt ccaccattcc cattagcatc   1860420
tgcaaaaagt tttcacccat agctggcaat gcaatattaa gaatgtcttt atttttctta   1860480
aacaatctct cctcctgatg aaaagaaact cagttggttt cccaaccgag tttgctccct   1860540
ctgtcttaaa gtcctaaata agcctcaacc gctgcttgca tgtcagcagc tgccactgtt   1860600
gtcttgtgac gaattggagc tatttcaagc ccatcaactg ctggtggcac tgcaacgcct   1860660
gagatttcat gtaattgagc caaggcttca aagtctgtta aacctgcttt tccagttaca   1860720
gcttctactg caactactgg gaacttgtat ggactagctg ttgaagcaat cactgtctta   1860780
gttacatctc cagtggccga ttggtatttt ttataaactg ctgaagcaac agctgtatga   1860840
gggtcctcga tataagaatc taactcacaa acacgcttga tctctgctgc cgtttcttcc   1860900
tcagtcgcat attcagctgc aaagaggtcc aaaatctctg catcaaagtc tgtcaactta   1860960
tattgtcctt gcgtgttcaa ggcattcata agttcagttg tcttttcagc attatttccc   1861020
aaaagatgga aaatcaagcg ctccaagttt gaagatacca agatatccat agatgggctg   1861080
gttgttacct taaactcacg ttttttgtca tagacacgtg ttttaaagaa gtctgtcaaa   1861140
acattgttgt catttgaagc acagattaat ttaccaactg gcaaaccaat ttgtttggca   1861200
taaaaggcag ccaagatatt tccaaagttt cctgttggta ctgtgaagtt aaccttttca   1861260
ccagctacaa tttcaccagt cttaaccaat tgagcgtaag cataaacata ataaacaatt   1861320
tgtggcacca gacgaccaat gttcatagag ttagctgatg aaaattgcaa cttgttggta   1861380
gtcaattttt cacgaagagc cacgtcgtta aacatgtgct tcacatttgt ttgcgcatcg   1861440
tcaaagttac catcaatagc aataacatga gtattgtcgc cagtctgagt ggtcatttgt   1861500
aactcttgaa tcttgctgac accatccttt ggataaaaga cgataatctc agtaccaggc   1861560
acattcgcaa accccgccat agcagctttc cccgtgtcac cagatgtcgc tgtcaagata   1861620
acaatcttgt tctccaaacc atgtttctta gcagcagtcg tcataaagta tggcaaaata   1861680
gacaaggcca tatccttaaa ggcaatcgtt gaaccatgga aaagttccaa attgtattgc   1861740
ccatctaatt tcactaatgg tgcaatagct ggagtatcaa atttgctatc gtaggcattg   1861800
ttgatacagt agtccaactc ctcaactgta aagtcatcta aaaatgctga caaaactagc   1861860
ttagcaactt cctggtaaga agcatctttc aatttgtcaa agttcaaatc tacctttgga   1861920
taagtatccg gtgtaaacaa accgccgtcc gtcgccaaac cttgcaaaat tgcttggctg   1861980
gcagttactg tattgttggc atcacgcgtt gattgataaa ctaatgtcat tactctctat   1862040
cctttatcta tagtctcgtc cattatatca tgatttttca gaaaattctc cctttataag   1862100
agaaattata ggctcaattc ttctctcaaa ggctgtaaat aggtcatttc ttccttattt   1862160
ctcaccacta gtccctcctc agctagtagg agtaagtctt tggaaaattc aataatcgta   1862220
gtttcttcct catctgtaag atttttctta gaaaattgtc tccttaaaga cttgtaatca   1862280
taaccaaata ctttaaagaa aggtgctgtt tctaagtaag cttctaactt gtctaaatta   1862340
accaataatc ccaagtgaaa agctgcagaa gcaaaagtcc tatcaagtgg ctgtgtacac   1862400
acactacgaa actcaactgt tcctcgagtc gttaaatctt ggtactggta actacgatga   1862460
gtttcaaaat ccttctcttg ggggtaaata ataacctcat ccccattcag agcaaatgct   1862520
tggatttcgg acgtagccaa atagtcccca gcctgaatag gataaaaata ataggtctgc   1862580
ccatcacgtt ccgcagtaaa aatcgcagaa tgatttagat agtcaaaaaa atcagtttca   1862640
tcattaagga gtctagcatt gaccccaaca ttctctggat agataccatg catagattct   1862700
tcccagaaaa tatcccttga aattttcgta tcccaatccg cacccgaaaa ttcagagttt   1862760
gcaaataaat aagccttagc cgcttcaatt tgagtaaaag cattaatcac ccgtaagtag   1862820
ttggtttttg aaatatccag ctgaacctgg ctcccacaga taaaagtacc atattcaggg   1862880
aaatgatgta aatctgattt aataatattt ctactcaaat tcaaataatc catcaacatc   1862940
tgatagcgtg gataagccac tggacaattc tcatttttat cccagttggg atggatacca   1863000
cagccaacaa tagcatgatt tgattcagct aactttctct gaattacatt catataatta   1863060
ttgaaacgat tttcgacctc ttgaatcgtt tcagccttac caaatgcaaa ctcaatcgtt   1863120
gtataggaaa cttcaaataa aatagcatcc tgacttatcg gatctactaa ctggatcaga   1863180
ttgccaaaat catctacctt tgctacggtg agatccaaag tagaaactaa ataatgaaat   1863240
agatccttca taacttcaac atctgtagca tccccttcta aacttgcaac aggatactcc   1863300
aactcaattc cgacaaacaa ttcaggattt tctttaatat ttttcaaata ccgatgtttt   1863360
aataaatcga tagaacaaga catactcccc tacactttct taatctaaat aaaatttgaa   1863420
taactataat tataccaaaa ataatataaa aaaggaacga agaataacaa cgttcctaac   1863480
actatactat accggcggcc ggggtcgaac cggcacgtcc ttgcggacac tggattttga   1863540
gtccagcgcg tctgccaatt ccgccacgcc ggcaaatagt aactggggta gctggattcg   1863600
aaccaacgca tgagggagtc aaagtccctt gccttaccgc ttggctatac cccaatataa   1863660
aataggcgag tgatggggat cgaacccacg catgccagag ccacaatctg gtgtgttaac   1863720
cacttcacca cacccgccat aattctatta acacgggcag taggaattga acccacactg   1863780
aaggttttgg agaccttagt tctaccttta aactatgccc gtaaaatgga aggggaggga   1863840
ttcgaacccc cgaacccgaa ggagcggatt tacagtccgc cgcgtttagc ctcttcgcta   1863900
cccttccaaa atatataaat ggcgcgagac ggaatcgaac cgccgacaca tggagcttca   1863960
atccattgct ctaccaactg agctaccgag ccttattgcg ggagcaggat ttgaacctac   1864020
gaccttcggg ttatgagccc gacgagctac cgagctgctc catcccgcgt taatataaaa   1864080
ggaggatgtg ggattcgaac ccacgcacgc ttttacacgc ctgacggttt tcaagaccgt   1864140
tcccttcagc cggacttggg taatcctcca aaatagttta tacgggaaca agcccgtgtc   1864200
ctcttagtga acagataata ttccaatccc ctagtaatgg actaaacact atgggcacga   1864260
gtggactcga accaccgacc tcacgcttat caggcgtgcg ctctaaccac ctgagctacg   1864320
cgcccaagtc aaaaacttgg tacaaagaac aaagttcaaa gcgggtgacg agaatcgaac   1864380
tcgcgacaac agcttggaag gctgtagttt taccactaaa ctacacccgc taaaatggga   1864440
gttaacggga tcgaaccgct gaccctctgc ttgtaaggca gatgctctcc cagctgagct   1864500
aaactcccta gagctaagcg acttccctat ctcacagggg gcaaccccca actacttccg   1864560
gcgttctagg gcttaacttc tgtgttcggc atgggtacag gtgtatctcc taggctatcg   1864620
tcacttaact ctgagtaata cctactcaaa attgaatatc tattcaattt aagaaaaccg   1864680
ttcgctttca tattctcagt tactttggat aagtcctcga gctattagta ttagtccgct   1864740
acatgtgtcg ccacacttcc acttctaacc tatctacctg atcatctctc agggctctta   1864800
ctgatatata atcatgggaa atctcatctt gaggtgggtt tcacacttag atgctttcag   1864860
cgtttatccc ttccctacat agctacccag cgatgccttt ggcaagacaa ctggtacacc   1864920
agcggtaagt ccactctggt cctctcgtac taggagcaga tcctctcaaa tttcctacgc   1864980
ccgcgacgga tagggaccga actgtctcac gacgttctga acccagctcg cgtgccgctt   1865040
taatgggcga acagcccaac ccttgggacc gactacagcc ccaggatgcg acgagccgac   1865100
atcgaggtgc caaacctccc cgtcgatgtg aactcttggg ggagataagc ctgttatccc   1865160
cagggtagct tttatccgtt gagcgatggc ccttccatac ggaaccaccg gatcactaag   1865220
cccgactttc gtccctgctc gagttgtagc tctcgcagtc aagctccctt atacctttac   1865280
actctgcgaa tgatttccaa ccattctgag ggaacctttg ggcgcctccg ttacctttta   1865340
ggaggcgacc gccccagtca aactgcccgt cagacactgt ctccgatagg gatcacctat   1865400
ctgggttaga gtggccataa cacaagggta gtatcccaac agcgtctcct tcgaaactgg   1865460
cgtcccgatc tcttagactc ctacctatcc tgtacatgtg gtacagacac tcaatatcaa   1865520
actgcagtaa agctccatgg ggtctttccg tcctgtcgcg ggtaacctgc atcttcacag   1865580
gtactaaaat ttcaccgagt ctctcgttga gacagtgccc aaatcattac gcctttcgtg   1865640
cgggtcggaa cttacccgac aaggaatttc gctaccttag gaccgttata gttacggccg   1865700
ccgtttactg gggcttcaat tcataccttc gcttacgcta agcactcctc ttaaccttcc   1865760
agcaccgggc aggcgtcacc ccctatacat catcttacga tttagcagag agctgtgttt   1865820
ttgataaaca gttgcttggg cctattcact gcggctgact ttaagtcagc accccttctc   1865880
ccgaagttac ggggtcattt tgccgagttc cttaacgaga gttctctcgc tcacctgagg   1865940
ctactcgcct cgactacctg tgtcggtttg cggtacgggt agagtatgtt taaacgctag   1866000
aagcttttct tggcagtgtg acgtcactaa cttcgctact aaacttcgct ccccatcaca   1866060
gctcaatgtt atagaattaa gcatttgact caattcacac ctcactgctt agacagactc   1866120
ttccaatcgt ctgctttagt tagcctactg cgtccctcca tcactacata ctctagtaca   1866180
ggaatatcaa cctgttgtcc atcggataca cctttcggtc tctccttagg tcccgactaa   1866240
cccagggcgg acgagccttc ccctggaaac cttagtctta cggtggacag gattctcacc   1866300
tgtctttcgc tactcatacc ggcattctca cttctatgcg ttccagcact cctcacggta   1866360
taccttcatc acacatagaa cgctctccta ccatacctat aaaggtatcc acagcttcgg   1866420
taaattgttt tagccccggt acattttcgg cgcagggtca ctcgactagt gagctattac   1866480
gcactctttg aatgaatagc tgcttctaag ctaacatcct agttgtctgt gcaaccccac   1866540
atccttttcc acttaacaat tattttggga ccttagctgg tggtctgggc tgtttccctt   1866600
tcgactacgg atcttagcac tcgcagtctg actgccgacc ataattcatt ggcattcgga   1866660
gtttatctga gattggtaat ccgggatgga cccctcaccc aaacagtgct ctacctccaa   1866720
gaatctctaa tgtcgacgct agccctaaag ctatttcgga gagaaccagc tatctccaag   1866780
ttcgtttgga atttctccgc tacccacaag tcatccaagc acttttcaac gtgccctggt   1866840
tcggtcctcc agtgcgtctt accgcacctt caacctgctc atgggtaggt cacatggttt   1866900
cgggtctacg tcatgatact aaggcgccct attcagactc ggtttcccta cggctccgtc   1866960
tcttcaactt aacctcgcat cataacgtaa ctcgccggtt cattctacaa aaggcacgct   1867020
ctcacccatt aacgggctcg aacttgttgt aggcacacgg tttcaggttc tatttcactc   1867080
ccctcccggg gtgcttttca cctttccctc acggtactgg ttcactatcg gtcactaggg   1867140
agtatttagg gttgggagat ggtcctccca gattccgacg ggatttcacg tgtcccgccg   1867200
tactcaggat actgctaagt acaaagacta ttttaaatac gaggctatta ctctctttgg   1867260
ctgatcttcc caaatcattc ttctataatc tttgagtcca cattgcagtc ctacaacccc   1867320
gaagagtaaa ctcttcggtt tgcccttctg ccgtttcgct cgccgctact aaggcaatcg   1867380
cttttgcttt ctcttcctgc agctacttag atgtttcagt tcactgcgtc ttcctcctca   1867440
catccttaac agatgtgggt aacaggtatt acctgttggg ttcccccatt cggaaatccc   1867500
tggatcatcg cttacttaca gctacccaag gcatatcgtc gtttgtcacg tccttcgtcg   1867560
gctcctagtg ccaaggcatc caccgtgcgc ccttattaac ttaaccttat tttctgacct   1867620
ttcagtcata aactcttatt aatactacag cgttttcggt ttattttctt gttactattt   1867680
gatatagata ttcaattttc aatgtgcatt acttggtgat ctctcaccaa tggagcctag   1867740
cgggatcgaa ccgctgacct cctgcgtgca aagcaggcgc tctcccagct gagctaaggc   1867800
cccacaagac ctctcaagac taaacaagac caatgcgcag ttccttatcc ttagaaagga   1867860
ggtgatccag ccgcaccttc cgatacggct accttgttac gacttcaccc caatcatcta   1867920
tcccacctta ggcggctggc tccttacggt tacctcaccg acttcgggtg ttacaaactc   1867980
tcgtggtgtg acgggcggtg tgtacaaggc ccgggaacgt attcaccgcg gcgtgctgat   1868040
ccgcgattac tagcgattcc gacttcatgt aggcgagttg cagcctacaa tccgaactga   1868100
gactggcttt aagagattag cttgccgtca ccggcttgcg actcgttgta ccagccattg   1868160
tagcacgtgt gtagcccagg tcataagggg catgatgatt tgacgtcatc cccaccttcc   1868220
tccggtttat taccggcagt ctcgctagag tgcccaacta aatgatggca actaacaata   1868280
ggggttgcgc tcgttgcggg acttaaccca acatctcacg acacgagctg acgacaacca   1868340
tgcaccacct gtcacctctg tcccgaagga aagctctatc tctagagcgg tcagagggat   1868400
gtcaagacct ggtaaggttc ttcgcgttgc ttcgaattaa accacatgct ccaccgcttg   1868460
tgcgggcccc cgtcaattcc tttgagtttc aaccttgcgg tcgtactccc caggcggagt   1868520
gcttaatgcg ttagctacgg cactaaaccc cggaaagggt ctaacaccta gcactcatcg   1868580
tttacagcgt ggactaccag ggtatctaat cctgtttgct ccccacgctt tcgagcctca   1868640
gcgtcagtta caagccagag agccgctttc gccaccggtg ttcctccata tatctacgca   1868700
tttcaccgct acacatggaa ttccactctc ccctcttgca ctcaagttaa acagtttcca   1868760
aagcctacta tggttaagcc acagccttta acttcagact tatctaaccg cctgcgctcg   1868820
ctttacgccc aataaatccg gacaacgctc gggacctacg tattaccgcg gctgctggca   1868880
cgtagttagc cgtccctttc tggtaagata ccgtcacagt gtgaactttc cactctcaca   1868940
ctcgttcttc tcttacaaca gagctttacg atccgaaaac cttcttcact cacgcggcgt   1869000
tgctcggtca gacttccgtc cattgccgaa gattccctac tgctgcctcc cgtaggagtc   1869060
tgggccgtgt ctcagtccca gtgtggccga tcaccctctc aggtcggcta tgtatcgtcg   1869120
ccttggtgag ccgttacccc accaactagc taatacaacg caggtccatc tggtagtgat   1869180
gcaagtgcac cttttaagca aatgtcatgc aacatctact cttatgcggt attagctatc   1869240
gtttccaata gttatccccc gctaccaggc aggttaccta cgcgttactc acccgttcgc   1869300
aactcatcca gagaagcaag ctcctccttc agcgttctac ttgcatgtat taggcacgcc   1869360
gccagcgttc gtcctgagcc aggatcaaac tctcattaaa aagtttgagt tctcactcat   1869420
ttctgtcact gacagattta ttgttttttt cattgttcag tactacaact tatgttgtag   1869480
cgccctgcac attggttcgt cttgttcagt tttcaaaggt ctttgtcact tgcttctctc   1869540
aagcgacaac tatattagta tatcacagcc actttcactt gtcaacactt tttttgaaga   1869600
tttttaagtt tttttaaact ttttttcatc aagtgttcca accgcaacat accatagtcc   1869660
gtacgggatt cgaacccgtg ttaccgccgt gaaaaggcgg tgtcttaacc ccttgaccaa   1869720
cggacctgag ttgttatttt caactcttac tattatacag tcttttcaaa ctttgtcaac   1869780
tactttttct aatttttttt tattttttca acttatagta aaaaaagcca gaattatact   1869840
gactcttcta tcgctcatta aacttagaag cacgttcttt tccccaccaa taagggatta   1869900
gttctgcgac tttaactgtt tttcttatat tatagtccat catgaattct gcatctttat   1869960
tttcagcatt aagctctaaa aggaattctc tacaagcacc gcaaggcatg gctgaacttc   1870020
caccataagg tggtttgtct cgaaaggcta atactttctt aaccttagtt tgtcctgaaa   1870080
attggtacat attgaagagg gccgcccgtt ctgcgcagag atggaaaaca ccacaggttc   1870140
cctccataca gaatcctgta aatatttgtc catctcctgc ttctactgca gctacaacat   1870200
gattggcata aacaaagtct gatacttcat gtggattgta tagtttctgt gcttcttcgt   1870260
acatcttttc ccagatgtcc attattgtat cctctttatt tagagatttc ttttagcatg   1870320
ttttcgatat gctgaattga tttttcacgt ccaagcaaga aaattgtatc tggtaattct   1870380
ggcccatgca tttcgcctga aactgcgata cgaataggca tgaaaagatt tttcccttta   1870440
atacctgttt ctttttggac tgctttaatt tgtgggaaga tattttctgt cacaaattca   1870500
tcatctgtca tcgcttcaag ttttgctttg aatgcttcaa gaactgttgg aactgtttca   1870560
cccgtcatga cttcgcgctc tgcttctgtc aattctggga aatctgagaa gaaaagatct   1870620
gtcaatggga taatctcatc tactgatttc atttgtggtt tatagagctc aactaatttt   1870680
tcagccttgt cagtcaaacg gcctgcttcc tctaagaatg gttttgccat ttcaaagatg   1870740
gtttcaaggt ctgcattctt gatataatca ttgctcatcc agtctagttt tttctgatca   1870800
aaggctgctg gtgacttgct gaggcggttt tcatcaaaaa gtttaatgaa ttcttcacga   1870860
gagaaaatct catcttcacc acctgggttc caaccaagaa gagcaataaa gttaaagact   1870920
gcttctggaa ggtaaccttt ctttcggtaa tcttcgataa attgaagtgt attagtatca   1870980
cgtttagata acttcttacc agtttcagag ttgataatca aggtcatgtg accgaactct   1871040
ggagcttccc aaccaagagc ttcatagacc ataagctgtt ttggtgtatt agcaatatgg   1871100
tcatctccac ggataacatg agagatttgc atatcgtggt catcgataac aacggcaaag   1871160
ttgtaagttg ggtaaccgtc tttcttttgg ataacccagt caccaccgat attgccacct   1871220
tcaaattcga tatcgccttt gaccatatca tgccacttgt agatacctga ctcattgaca   1871280
gccaaacgaa cagttgggat gatccctgct gcttcacgtt ctgcgatgta agctgctttt   1871340
tcttcttcac tcataccaag gtattcattg atgtagcgtg gtgtttcgcc agctacttct   1871400
tggcgttcgc gttcagctgc caactcttct tctgtaacgt aagatttata ggcttttcct   1871460
tcagctaata gttggtcaat atatttttga tacaagtcca aacgctcaga ctggcgataa   1871520
ttctcatgtg attctggact ttcatcccaa tccatgccta accagcgaag gttttcaagt   1871580
tgtgaacgtt caccatcctc gacatggcgt ttacggtcag tatcttcgat acggatgaga   1871640
aatgttccac catgatggcg cgcatacaag taattaaaca atgctgtacg agcatttccg   1871700
atgtgtagta gtcctgttgg acttggtgcg taacgtacgc ggatatcttt tgacatagtt   1871760
tctcctatta tctaggcgtc tgcctttttg ctttctatat tatatcacaa gtcttggctg   1871820
agtccaattt ctatggataa agagagtaaa aagagtgggc aaaccactct tttcttctat   1871880
tatagacgtg cgttaagttc tttgctcaat tcttcaaatc ctggttttcc aagaagggca   1871940
aacatgttac gtttataagc ttcaacacct ggttggtcaa atgggttgat agcattcaag   1872000
taacctgaaa gggcaattgc caattcgaag aagtagatag tgtaaccaag agtgaaagcg   1872060
tcttgctctg gaagagtcac atacatgttt ggtacatcac catctgtgtg ggcaagaaga   1872120
acaccgtcag ttgctttttt gtttacaaag tcaacgtctt ttccttgaag gtaaccaagt   1872180
ccgtcaaggt cttcttccaa agtaggaata agcacgtttt tacgaggttt gtcaacacgg   1872240
acaactgttt caaacatgat acgagttcct tcttggataa attgaccaag tgagtgcaag   1872300
tcagttgaga agttggctga agttgggtag ataccttttt ggtcttttcc ttctgattca   1872360
ccagccaatt gtttccacca ttctgagaag tattgaagtg atggctcata gtttaccaag   1872420
atctcagttg catagccttt acgataaagg atgttacgaa cagctgcgta ttggtaagct   1872480
tcgttttcag agattttgtc tgaagtgtag tctttgcgag ctgcattcgc accttccata   1872540
agagctttta tgtcagctcc tgatgctgcg attgaaagca aaccaacggc tgtcaatact   1872600
gagaagcgtc caccgatatc atctggaaca acaaatgttc cccaaccgtt agcgtctgct   1872660
tcaaccttaa cagcaccctt ttggcggtca gttgttgcat agatacgttt gttagcttct   1872720
tcttgaccgt atttcttaac caagagttct ttaaagacac ggaaagcaat cgctggttca   1872780
gttgttgtac ctgatttaga aattacgttt actgagaagt ctttgtctgc aacatactct   1872840
accaagtcag caaggtaagt agatgagatt gagtttcctg cgtaaaggat ttgtggagct   1872900
ttgcgttctt cttttgtttg caagttagca aaatggtgat tcaagaagtc gattgctgct   1872960
tttgcaccaa ggtaagatcc accaataccg atcacaacca aaacatcgct gtctgacttg   1873020
atttgctcag cagctttcaa gatgcggtca aattcttcgc ggtcgtattt ttcaggaagg   1873080
tccaaccatc ccaagaagtc gctaccagca ccagttcctt tacggattaa ttcatctgct   1873140
gctgttactt gtgattgcat gtattccact tcatgtggtg caacaaattt gtctaaaact   1873200
tttgaataat caaatttaat atgtgacatg ttcttcctcc aatatttctt cttttctatc   1873260
ataacgctta ccttcgtttt tttcaagttt ttttgtcgaa tttctccaat ttttatcaga   1873320
attcaaacgt ttgcgtaaaa tgccacattc taaaaatttt gaaaaaataa aagaaagaac   1873380
gaccagatgt tccaatcgtt acagttcatt caataaatac tcaaataatt ctaaattgcc   1873440
atcttcttca ttaaccagaa actctggatg ccactgtaaa ccgataatgc ggtgctcgtc   1873500
gatagactca atcgcttcaa tagtttggtc tcttgaatca atagcagtta cacggaaatt   1873560
aggtgccaaa tctttaatgc tttgacgatg gactgagttg acctgacttt ctttcccaaa   1873620
tagcttagcc accacgcttc cttctactgt ctcaatagag tgagatgtcc cgaaaggtag   1873680
tccttgccag tgaccttcga tttcttgatt gagggttcca ccaaaggcaa cattgacaag   1873740
ttggacaccg cgacagattg ccataattgg tttattctga cgaagcgctt ccttcaagag   1873800
tgccaattca aattcgtcac ggaccagatt gtaatcatcg ctctcgacgg tctttttctc   1873860
tccataaaac tgaggatgaa cattttggcc tcctgtcaaa atgagtttgt caatcatttc   1873920
cacataatca cgtacaactg actcatcacc aacaggaatg actaaaggga gaccaccgac   1873980
ttgacgaatg atctctgcga atctacaaga tacagatgaa tgaatgattt tgccttctgc   1874040
gtctacggga catagatttg cagcaactcc tacaaccgtt ctagccatga tgcctctcct   1874100
ttcgaatgct aacgatagtc ctatcatatc actcaaaatg actttcgtct aatatgtttt   1874160
ttttaaggct gtgataaaca ttttttatgg acaagaaaaa gctgcccaca taggacaact   1874220
tctttcttat tcgaaaacaa attgattgtg atagagttct gaataaaagc cacctagctt   1874280
caaaagttca tggtggttac cacgttcaat gacttctcca tctttaagga caataatctg   1874340
atctgcattg agaatggttt tcaagcggtg ggcaatgacg aaactagttc tacctgctac   1874400
aaccacctcc atggcatgct gaatcttgct ttctgtcacc gtatctacgt ttgaagttgc   1874460
ttcatcgaga atgagaactt ctggatctgt catcagggtt cgagcgattg aaatcaattg   1874520
cttctgccct gttgaaaaga tgctctggtc atcatcaata agagtatcgt acttatcagg   1874580
caaactttcg atatagtcgt gaatgtgggt tgcttttgct gctacctcaa ccatttcctg   1874640
actagcatct ggcacaccaa atcggatatt gtctctaatc gttccgctaa acaagaccga   1874700
atcttgcaat acaattccca ccttgcttct aagactatct aagtcatagc cacgaatgtc   1874760
tttaccatca aaataaatac caccagcatc aacatcataa aagcgattga tgaggttcat   1874820
aatagtcgtt tttcctgaac ctgtcggccc aacaactgct gtcatctggc ctttaggggc   1874880
agaaatgctg acatctttca aaataggttt atcaggcaag tatgaaaaaa cgatatgact   1874940
gatttcaaca ctttcttgca acttagtgaa ggttggagcc ttttcaggtc ggatttcctc   1875000
ctctgcatca aacatttcct gaattcgttc agctccagta aaggccaact gaaggcttcc   1875060
ccaactcgct gcaacttgga taataggctg gtagtactgc tgtgaaaatt gtgcaaacat   1875120
aacaatcaaa cctagggctg tacttgtttc aatagactta tcattcaaaa gtacagccga   1875180
accagcaaag atgacgatgg ctgtattaat caggctcatc ccattcatga cagggaaaag   1875240
aattcctgag aacattcttc ctttaaaggt tgccttgcgc acgcgctcat tttgttcaag   1875300
aaatcctgcc atcatatcct cttgaattcc ttgcacaatc acggcttttt ggcctgagat   1875360
gctctcatcc atataggcgt tgagcttccc tacctctttc tgctggaggt tggtgtattt   1875420
gcgtgccatt ttcacgatga aaatcagcat aaggaaagcc aatggggtgc tggcaatggt   1875480
gatgagagcc agcgtcacat ttctcgaaaa catgacaaga atcagaccaa tgtataaaac   1875540
aatattgctc atgacctgaa tcaagctttc gttaaaggct tggaggatat tatccaaatc   1875600
actggtaaaa tgagacagga tatcgccatc ttgtcgacgg tcaaagaaag aaaccgtcaa   1875660
ctgagcaagc ttaccaaaga ggcctttgcg catctcgttg gtcgattctg caatcacgcg   1875720
cgtcatgaga cacatgtata ttacactaga gataaataga accaaaacca gcaggccaag   1875780
attgaccatg attcctgata ggctttgcca tacaagttct ggattgccat tttgataagc   1875840
ttgaactaaa ttggctagct gcgtcaccgc ttgtccagaa aagactggaa agagggcttg   1875900
ggcaaaagtc gccagaacaa tcatcaggat gacaactaca aatgagaact tgtagacctt   1875960
aaaataatgc caaaaaaatt gaactgtctt cattttactc ctccttatat tatatttagc   1876020
gcagttagct actgccaaag cccaagtggt atacttggaa taagccgctg tggattagtt   1876080
catttcctcc aatcgcttga caatttccga aaggatctaa ccacagcttt ttgttttaat   1876140
tggtaatgag tttgataacg catagacgtt ttatctcgtg taatgaaaac atcaaacatt   1876200
acaagaggct cattgacaag gcggaaacat gtgtcaatga cttgatggct gagttcaact   1876260
cggtcatcac gacggttact gggattgggg atcgtttagg ggcggtcatt ttagctgaga   1876320
ttcgaaatat tcatgccttt gataatcctg ctcaattaca agctttcgct ggactggatt   1876380
cttctattta tcagtcagat cagattgatt tagcaggaag aatggtcaaa cggagttccc   1876440
ctcatctgcg gtaggtactc atacaagctg ccaaagcatg ccctcgcttt tcgcctgctt   1876500
ttaaggccta tcttaagact aaattagaac aaggaaaaca ttacaatgta gccatcatcc   1876560
accttgcaaa aaaacttatc cgaaccctgt tttatatcct aaaaaaagag ctgccatttg   1876620
acgaacaaaa agtgatgtaa tttctgaaat taacacagga ttacctttga aaaaatggac   1876680
tttttcaagg gctttttgcc gtgctctaaa atcatcgcca aatcatcaaa ttgaaataag   1876740
aaatagttta gataaaacta ttgacttttc ttatagtttg tctttcattt ctgtgtttca   1876800
tagatttcac ggtaaacggc attgttggca accaagtctg catgcgtacc ttgaccaatc   1876860
aatcgtcctt gatttagaac caagatcttg tctgcatgga caaccgagct aattttttga   1876920
gcaataataa tggttgtcgt ccccttcaag tccttattca aagcttcttg caccaagcgc   1876980
tctgatttgg catccaaggc tgaggtcgaa tcatcaaaaa tcagaatacg tggattgctg   1877040
acaatcccac gcgcaatcga catcctttgt ttttgtccac cagagaaatt ggttccccgt   1877100
tcttcaactg gactttcaaa ggttttctcc atacgatgaa tgaattcact agcctgggca   1877160
atattggctg cgcgctccat ttcaaataga gtagcattcc ccttcccctg tctcaagtta   1877220
tctgcaatcg ttccactaaa aagaatggca cgttggagaa cgatggaaac tgttttacgc   1877280
agggttcctt cactcacttc tcgaatatcc ttgccaccga ttttaatggc cccgtcctgt   1877340
ggatcaaaga gacgtggaat caattgagcc aaggttgact ttcctgcacc agtcgctcca   1877400
actacaccaa ccatttgacc aggttcaata gtaaagctca catctttcag catcggttcc   1877460
ttgtccattg gataggtaaa ggtcacattt tcaaagctaa gacttccaac caactcttca   1877520
tctgggatat ccttgaaggt catagctggc tctgcgtcaa gaatttctcg aatacgacgc   1877580
atggaaatca tggcacggct gacagaattt cccaaaaatc caaccataac aatggtaaag   1877640
ataatctggc ttaggtaatt aacaaaagaa gcgatggaac caacaacaga cggatccgac   1877700
tgaaccattc ccgcgaccag ccaaatagag aggaagaccg ccccgtaacc aaccaacatc   1877760
ataaagggtt ccactactga aaaggcataa ccaatgtaaa ggttttgacc aagaagctcg   1877820
tctgagacct ctgtaaactt agcaaattgc tctttttctt ggacaaagga cttgaccaca   1877880
cgaacgccac gtaaattttc cttggcaatg gcattgatgc gctcaagaag ggtttgaaac   1877940
ttggcaaaac gaggccccat cattcccatc atgacagcag tcaaaccaaa aatcaagact   1878000
accatgagaa caatcaccca ccacagagaa ggtaaggttt gaaccgctag gataaacgaa   1878060
ccgatgaaca agaggggaag tctgaaaaga atttggaagg tcatcatgac aacgttctga   1878120
atctggttga tatcatttgt cattcgaacg actagatttc ccgcattaaa ttgttcaata   1878180
tcagcataag aaaaggtttg aattttacgg aaggcatcct cccgaaggtc ggatgaaact   1878240
ccttgggcaa tataggctgc gaggacaaca ttgagtccac cagcaactag accgactacg   1878300
gccacaccaa tcaaccaagc cccgatacta taaatagctt catatttccc agtaaggagg   1878360
gcgcctaaga cttcctgcag ataacgcggt tgcagaagtg aactagcaac catcaagcct   1878420
gtcatcagga gcgaagccag ggcctgccac ttgtaggttt ttattttctg aatcagcata   1878480
ctttctcctt aaaaaataga caaaagggag cgacaatgcg tcagctcctt ttcattctgt   1878540
ttgtgtgatg ttattctagc aaaaaagtgg agaattgtca aagaagtctc cttgatacag   1878600
ctagattaac tagtgagtct tggttttata gtttctgttt taactctact aagacattca   1878660
taacctgcat aggtgtcata ttatacacat ccagtttagc taattctgct aggataggat   1878720
gctcttctgc cctatcaaag agtgaaatct gttcagtgac agcactagtt tgtctcatgg   1878780
gaggaggact ctctgttcct tgattctcta gctgagtcaa aatcttatcc gcccttgcta   1878840
aaaggtctgc tggcaagcca gcaatcttgg caacatggat accgtagatt tatcagctgg   1878900
tcccggttca atcttgtgaa ggaaggtgac ctgcccatcc tgctccaaag ttgccacgtg   1878960
gacattgacc aagtgttgta aactagactc cagactagtc aactcatggt agtgggtcgc   1879020
aaagagggtc ttagctccga tgtgctcatg gatatattcg atgatggact gagcaagagc   1879080
catcccgtca taagttgcag ttccacgtcc caattcatca aagagaatga gagagttctt   1879140
ggtcgcatgc gaaatggcat tattggcctc catcatctcc accataaagg ttgactgacc   1879200
cgaaaccaag tcatctgctg ctccgatacg ggtaaaaatc gcatcaaaaa tcggtaaatg   1879260
ggcgctttca gcaggaacat aggaacccag ctgggccata accgccgtca tggctaactg   1879320
acgcatatag gtagacttcc cactcatgtt tggccctgta accagttgaa tactggtatc   1879380
ttctgccatc tgaatcgtat ttggaatata ggtctgagcc cccataacct tttcaacgac   1879440
agcatggcgc cctttccgga tatcaatttg tgaatcgtca ccaaactcag gtcgaatcaa   1879500
atgctgggtt tcagccacaa ccgccagact ctgtaagaca tcaaccgtcg caattccttg   1879560
ggctagagct tgtaaacgct ggatgtactt gccgacctct tcacgaatgc gcataaatat   1879620
ttcgtattcg aggttggctg acttctcacg cgcctcaagc atatctccct cgatacgggc   1879680
taattcttcg gttccaaagc gttctgagtt tttcagcgtc gccttgcgga aaaagtgagc   1879740
tggcacattt cctagttgcg aattggtcac atgaaaatag tagccatcct ttttattgta   1879800
gtcaatcttg agcgtgctga taccagagtt ttctcgctcc ttagcctcaa tctcagcaat   1879860
ccagctagtc ccttctctga gaacgcaacg atacttgtct aaagtctcat caaatccagt   1879920
ccggataatt cccccatctg taatcacatg aggagcttca ggagcaatcg ctgcgctaat   1879980
caaactctcc aactcaggga ttgcatccag ttgtgcgatg agataggcta gagtaggttg   1880040
ctccatccct tctaaaatcg cacgaatccg tggcacacta gacaaggtag tcgccaactg   1880100
caagagatcc tttggattgg ttttgccaaa agaaacacga ctagccaagc gctcaatgtc   1880160
ataaacaccc ttgagactgt ctgtcaagtc actacgctca aagaaatggt cgagaaagac   1880220
ctgcactact tcttgacgtt ggacgattcg ttccttatca atcaaggggc gatgaatcca   1880280
agaacgcaag agacgcatcc ccatagccgt tttggtttca tccaaaagcc agaaaagact   1880340
gccttgtttc ttacctgagc gagcattctc aaccaaatcc agactagcct tggtcgcata   1880400
atccatctgc aagaaatcct taatttcgta gcggataaca ggtttgaggt ggttcaattc   1880460
cctcatctga gtccgatgaa catactggag cagcttacta gatgccgttt gctccaccgt   1880520
tgccaatcgc aaatccaata aatgaaggtc ttcaaagctt tctttttcat aagagagtac   1880580
cagattcatc tggcggctga ggatttgttc ttcttcctca gacaagtcat aacccaacac   1880640
cacttctcga gccttgaggt tacggatttc cccacaaacc agcgtgaaat ccaaaagacc   1880700
tgtcacataa aagtcacccg tcaccaaatc catataagct aggccaaatt gattgccttc   1880760
gcggtctatg gaaaccaaaa aattattctg actgtccggc ttactgctat cgaccactgt   1880820
ccctggcgta atgacctgaa caacctctcg tttaacaacc ccaactgctt gtttaggatc   1880880
ttccatctgc tctgcgatag ccaccttata accctgctca atcaagacat cgatatactg   1880940
ttgggcagaa tgatagggaa cacccgccat agggatcgga ttgtcggcat tcttgttgcg   1881000
actcgttaag gaaatttcca gaatctgcgc agcattgacc gcatcctcat aaaataattc   1881060
ataaaaatca cccatccgaa agagcaaaaa agcatctgga tattgctttt taatatccac   1881120
atactgttgc atgccgggtg ataacttttc tatcgccatt ttctgtctct ccttttcaaa   1881180
aataagtctt gagagcaact cccaagacct tacttatctt tcatcaaatc tagcaaacga   1881240
tcttccatga gtttggcaac gtgctgatct cgacaaataa ccaataaggt attggcacca   1881300
gcaactgttc ctaaaatcca ttcatccttg tttacatcta caatatttgc caaaacagag   1881360
gcttctccca atttggtatg aagcaccaag gtaaactctg ctcttgcaac accttctaaa   1881420
tgatgagaca aaaattccac caaatcaatc ttttctgtct catttactag tacataatac   1881480
accatatcat ttttcttgac cttggtcaag ccgatttcgc gcaaatcacg agacaaggtt   1881540
gtctgcgtca cacaaacatt gtgcgcctcc aaccgatctt gaatttcttt ttgtgtactt   1881600
aatttctcct cagtaatcat tttttttatt aactgatgac gatctctttt tctcataaaa   1881660
tcctcttgcg tgcatattta taactatatt tataaccata ttataccaaa aaaacaggag   1881720
atttcaaaaa ttttttcttc tttctttaaa attgtgataa aatagtagaa aagtccaaaa   1881780
aggagctctt aatgaataca aaagaattga ttgctagcga attatctagc atcattgata   1881840
gcctggacca agaggctatt ttaaagttac tggaaacccc taaaaactca gaaatgggag   1881900
acattgcttt ccctgctttt tctcttgcaa aagtcgaacg taaagcacca caaatgattg   1881960
cggctgaact ggctgaaaaa atgaacagcc aagcctttga aaaagttgtc gcaacaggac   1882020
cttacgttaa ctttttcctt gataaatctg ccatttctgc tcaagtattg caagctgtta   1882080
ccactgaaaa agaacactat gctgaccaaa atattggtaa acaagaaaat gttgttatcg   1882140
acatgtctag tccgaatatc gctaaaccat tttctattgg ccacctgcgt tcaactgtta   1882200
tcggagatag cttgtcacat attttccaaa aaatcggtta tcaaacggtc aaggtcaacc   1882260
atttgggaga ctggggtaaa caatttggga tgttgattgt tgcctacaaa aaatggggcg   1882320
acgaagaagc tgtaaaagct catccaatcg atgaactcct taaactctat gtccgcatca   1882380
acgctgaagc tgaaaatgac cctagcttgg atgaagaagc gcgcgaatgg ttccgtaaac   1882440
ttgaaaatgg agatgaggaa gctctcgctc tttggcaatg gttccgcgat gaaagtttag   1882500
tggaatttaa ccgcctttac aatgaattga aggttgaatt tgacagctat aacggagaag   1882560
ccttctacaa tgataagatg gatgcagttg tagacattct ttctgaaaaa ggactacttc   1882620
ttgaatcaga aggtgcccaa gttgtgaatc ttgagaaata tggaattgaa catccagccc   1882680
tcatcaagaa gtctgatggt gcaactctct atatcacacg tgacttggct gcagccctct   1882740
accgtaaaaa cgaataccaa tttgctaaat ctatctatgt cgttggtcaa gaacaatctg   1882800
cccactttaa acagctcaaa gctgtcttgc aagagatggg ctacgactgg agtgacgaca   1882860
ttactcacgt tccttttggt ttggttacaa aagaagggaa gaaactctct actcgtaaag   1882920
ggaatgtcat cttgctagag cctactgttg cagaggctgt tagccgtgcc aaggtccaaa   1882980
tcgaggctaa aaatcctgaa ctagaaaaca aagaccaagt agcacatgct gttgggattg   1883040
gagccattaa attctatgac ctcaaaaccg accgtacaaa tggatacgac ttcgacctag   1883100
aggctatggt atccttcgag ggtgaaactg gaccttacgt tcaatatgcc tacgctcgta   1883160
tccaatctat cttacgcaaa gccgatttca aaccagaaac agctggcaac tatagcttga   1883220
atgatactga aagctgggaa atcattaaac tcattcaaga cttcccacgt attatcaacc   1883280
gtgcggcaga taactttgaa ccttctatca ttgctaaatt tgcaattagc ctggctcaat   1883340
cctttaacaa atactatgca catacacgta tcttggatga aagcccagaa cgcgacagcc   1883400
gtctagccct cagctacgca accgcagtcg ttctcaaaga agcccttcgc ttgcttggag   1883460
tagaagcgcc agagaagatg taaatcgcca aagttacttg attgcaaagc aatctaagta   1883520
actaacgcca aatcctattc ggactttggc taggcgcttc actagtttta ggacataaat   1883580
atgatcgatt tatgtcctaa aacgtcgtaa tcttaaagtt attggaacta aagttcctaa   1883640
ttgttagacg ctagccgctt atatgcgaac tagctaactg cttcactagt catgacccct   1883700
aaatataatc gatttagagt ccatgacgtc gtaaccagag acacttgcct aaacgcttca   1883760
ctaattcacc taaccaaata atagacttcc tgcaaaacta gaatcctagt tcatgattga   1883820
taatgccagc aatcaaattc attcgtaatc cgaagtgttt acgatgattt cgataggttg   1883880
ttgaaatcat tttaaacgtt tttactttgg caaagatgtt ctcaaccttg cttctctcct   1883940
tggatagcgc atggttatag gctttatctt caactgttag tggcttgagt ttgctggatt   1884000
tacgtggagt ttgtgcttga ggatatatct tcatgagccc ttgataacca ctgtcagcca   1884060
agattttacc agcttgtccg atatttctgc gactcatttt gaacaacttc atatcatgac   1884120
aatagttcac agcgatatcc aaagaaacaa ttctcccttg acttgtgaca atcgcttgag   1884180
ccttcatagc gtggcatttt ttttaccaga atcattcgct aattcttttt ttagggcgat   1884240
tgatttgtac ttccgtcgca tcaatcatta ccgtgtcctc agaactgaga ggagttcttg   1884300
aaatcgtaaa accactttga acaagagtta cttcaaccca ttggctccga cggataaaga   1884360
agacttgata agaactctag agttagctcc ccatattgaa ggtggctatt ttagacaaac   1884420
aaaaaaagct tcagacacta taaaccttgc tggtaaggga agggcgcttt ataccagtat   1884480
ttatttctta ttagaagaaa cgaatccttc acattttcac cgattgacag cagatgaaat   1884540
ctggtatttt catgcaggat ccccacttac tgttcacatg attacagcag atggtcacta   1884600
cgaagcagtc actttaggcc tggacatatc caaagggcaa caacttcact actgtgttcc   1884660
taagggcact atttggggat caacagttga taaggatgat gctctggttt cttgtcttgt   1884720
tgctcctggt tttgaatttg aggattttga attatttgaa agggtagatc tactggcgac   1884780
ctatccagag cacaaggaga tgattgagcg tttgaccaga tactagtctt gataggcaaa   1884840
tttaatctga tttagcaatg ttaggatttc tgataattgt gttataatgt taccaatagg   1884900
agataataga tgacaaaaca agtcttatta gtggatgatg aagaacacat tctgaaattg   1884960
cttgactacc atttaagtaa ggaaggcttt tctactcaat tggtgacaaa tggacggaag   1885020
gccttagctt tggcagaaac agaacccttt gattttatct tgcttgatat catgttacca   1885080
caattagatg gcatggaagt ttgtaagcgg ctgagagcca aaggcgtcaa aactccaatt   1885140
atgatggttt ctgcgaaaag tgatgaattt gataaggttt tggccttgga attaggggct   1885200
gatgactacc tgaccaagcc ttttagccct agagaattgc tggcgcgtgt caaggctgtc   1885260
ctcaggcgaa ctaaaggaga acaagaagga gatgattcag ataatatcgc tgacgattct   1885320
tggctatttg ggaccttgaa agtataccct gagcgtcatg aagtctacaa ggcgaataag   1885380
ttactgagtt tgaccccaaa agaatttgaa ctcttgctct atcttatgaa acatcccaac   1885440
atgacactga ctagagagcg tcttttggaa cgtatctggg ggtatgactt tgggcaggaa   1885500
acacgtttgg tggacgttca tattggtaag ttgagggaaa aaattgaaga caatcctaaa   1885560
gcccctcaat ttattcgaac cattcggggt tatggttata agttcaagga gttatagatg   1885620
aaacgctacc ttcaattttg gctagtcaat ctaagtgtta gcctcattct gattgcaggg   1885680
atggcattaa cttggatcag taaaggcatc ggtctctttc ttctagccct ttctttggga   1885740
ctaggtggct actggctctt ttgcctttgg aaatgggaag ttgcttttga gaccttgcac   1885800
caacctctct tgaccagtag tgaatacttt ttagaaaaag ggcaagaaga cttaaagtct   1885860
ttggctcagt atgtgtctgg cctaaaaacc aaagtctccc aacaggatca gcaatacaag   1885920
gatctagccg aaacaatgga ggttcttctg tcgcacctaa ccatggggac gtttttagtt   1885980
tccgctcaag gtcagatgtt attatccagt cgctctctgc ctcattattt tcccgatgtg   1886040
gacggcgaca taagttcact tgatgacctc aaacggatgg atattcggaa tttagttcac   1886100
caagcctttg atcaaaaaac aaggttaaaa caagaagtaa gtgggtttca tgagggtgac   1886160
ttgattttag aagtgacagc agttcccgtt tttagcccca cccaatctgt ggaagctgtg   1886220
ctcgtcttgc tatatgattt aacaacgatt agaacttatg aaaagttaaa tttagccttt   1886280
gtctcaaatg cctcccatga attgaggaca ccagttactt cgattaaggg ctttgctgaa   1886340
accattaagg ggatgtcagc tgaagaagaa gcgctcaagg atgactttct agacattatt   1886400
tacaaagaaa gtttgcgtct tgagcatatt gttgagcatc ttcttacctt atctaaggct   1886460
caacaaatgc ctatacaatg gacgaccctt tctttggcag aatttgtaca ggatttgact   1886520
caaagcttgc aacctcagct caagaagaag gatttacagc taaaggtgca ggtgccagat   1886580
gatgtcaccc tcgtatcaga tagtcaatta ctttcccaaa tcttactcaa tcttttatcc   1886640
aatgccatcc gttacactga acaaggggga aaaattgagg tcaagaccca aaaggtgaac   1886700
gaaggcatta agatttctgt atcagataca gggattggta ttagtcaatt agagcaggat   1886760
cgtatttttg aacgttttta ccgagttaat aaaggtcgaa gcagacaaac tggtggcact   1886820
ggtcttggcc ttgccattgt caaagaactc agtcaattat taggtggcca agtcacggtg   1886880
acgagtcagc ttggcagagg cagttgcttc acgatttttc ttcctaacca atctttcgca   1886940
caggactaat aatttttaaa gctattttta ggagcagcca tttttcaaaa gtggcttttt   1887000
ttgattcttt acacaatctt tacatgaatc agggataaac ctttacaaag acttgttaga   1887060
ctataaatgt agtaagccta cacaagaaaa atacatagag ataaaggtga ttattatgaa   1887120
attcaaaaaa atgcttactc ttgcagccat tggcttatca ggatttgggc ttgttgcctg   1887180
tggcaatcag tcagctgctt ccaaacagtc agcttcagga acgattgagg tgatttcacg   1887240
agaaaatggc tctgggacac ggggtgcctt cacagaaatc acagggattc tcaaaaaaga   1887300
cggtgataaa aaaattgaca acactgccaa aacagctgtg attcaaaata gtacagaagg   1887360
tgttctctca gcagttcaag ggaatgctaa tgctatcggc tacatctcct tgggatcttt   1887420
aacgaaatct gtcaaggctt tagagattga tggtgtcaag gctagtcgag acacagtttt   1887480
agatggtgaa taccctcttc aacgtccctt caacattgtt tggtcttcta atctttccaa   1887540
gctaggtcaa gattttatca gctttatcca ctccaaacaa ggtcaacaag tggtcacaga   1887600
taataaattt attgaagcta aaaccgaaac cacggaatat acaagccaac acttatcagg   1887660
caagttgtct gttgtaggtt ccacttcagt atcttcttta atggaaaaat tagcagaagc   1887720
ttataaaaaa gaaaatccag aagttacgat tgatattacc tctaatgggt cttcagcagg   1887780
tattaccgct gttaaggaga aaaccgctga tattggtatg gtttctaggg aattaactcc   1887840
tgaagaaggt aagagtctca cccatgatgc tattgcttta gacggtattg ctgttgtggt   1887900
caataatgac aataaggcaa gccaagtcag tatggctgaa cttgcagacg tttttagtgg   1887960
caaattaacc acctgggaca agattaaata aaatgtttgc tccataaatc tctaaagaga   1888020
tgcagacgtt tcatcgtaca ataagataaa gaaggcaagt agggaggtgt cgtatctccc   1888080
ttactttctt cactagaaag gacaagatgt gacaaaacaa gccttcaaag aagcagtttt   1888140
tagggcaatt tttttcatga gtgcaacagt agctgttgta gctattttgc taatctgttt   1888200
ctttattttt agtaatggct tacctttcat agctaactac ggctttgccc gttttttatt   1888260
aggcagtgat tggtcgccaa cgaacattcc ggcaagctat ggtattttac caatgatcgt   1888320
tggttcctta ttaattacct taggagcgat tgtgattggg gtgccaacag gcatcttgac   1888380
atcggtgttt atggtttatt attgtccaaa gcccgtctat ggcttcttaa aatcagctat   1888440
caacttgatg gcagccattc catctattgt ttatggtttt ttcggcctac aattattggt   1888500
gccttggatt agaagctttt taggaaatgg catgagtgtc ctaaccgctt cgttactatt   1888560
aggaataatg attttgccaa ccattatcag tttgtcagaa tctgctatcc gaacagttcc   1888620
caaaacgtat tattctggta gcttggctct aggagctagt catgaacgga gtatttttag   1888680
tgtcatcttg ccagctgcga gatctggtat tttatcagca gttattttag gaatcggtcg   1888740
cgcagtaggt gaaaccatgg cagttatttt ggtggcaggc aaccagccga ttattccaag   1888800
tggactcttt tcaggaacca gaaccttaac aaccaatatt gttctggaaa tggcttacgc   1888860
atcaggtcag catagggaag cccttattgc aacctcagca gttctctttt tccttattct   1888920
cttgattaat gcctactttg cctacttgaa aggaaaatca tcttatgagt aaatacctgc   1888980
taaaacttct cgtttattgt ttttcagctt taacctttgg ctctctcttt ttaatcattg   1889040
gttttatcct catcaaaggc ttacctcatc taagtctatc cctcttttct tggacttata   1889100
cttctgagaa catttccctt atgccagcga ttatttccac cgttattctg gtctttggtg   1889160
ctcttctttt agccttgccc atagggattt ttgctggttt ttatcttgtg gaatatacaa   1889220
aaaaagattc cctttgtgtt aaaatcatgc gattggcctc agatacctta tctgggattc   1889280
cttccattgt ttttggtctg tttggcatgc tcttctttgt agtcttctta ggttttcaat   1889340
actctctgtt atcaggaatc ttaacctcag ttatcatggt gttgccagtc attattcgct   1889400
caacagaaga agccctttta tctgttagtg atagcatgcg tcaagcaagt tatggacttg   1889460
gggcaggtaa gttacggact gtttttagaa ttgttctacc agttgccatg ccaggtattt   1889520
tagctggagt gatactagct attggccgta tcgttggtga aacagctgcc ctcatgtata   1889580
cattaggtac ctctaccaat acgccaagta gtctcatgtc ttcaggccgt tctctagccc   1889640
tacatatgta tatgctgtca agtgaggggc tacatgtcaa tgaagcctat gctaccggcg   1889700
tgattttgat tattactgtt ttaatgataa atactctatc aagcttatta tctcgaaaac   1889760
ttgtgaaagg agcttcctag tatgggaaca ttttcagtca gacacctaga cttattttac   1889820
ggggattttc aagccttaaa aaatatttcg attcaattac cagaaagaca gattactgcc   1889880
ttgataggcc catctggttg tggcaaatca acttttctaa aaacccttaa ccggatgaac   1889940
gatttggttc cttcttgcca tattgaaggc caagtcctct tagatgagca agatatttat   1890000
agtagcaaat tcaaccttaa tcagctacgt aagcgtgtag ggatggtttt tcaacagcct   1890060
aatccctttg ccatgtctat ctatgataac gtggcttatg gcccaaggac acatggtatt   1890120
cgagacaaaa aacaattaga tgccttagtg gagaaatctt taaaaggggc agccatttgg   1890180
gaagaagtca aagatgatct taaaaagagt gccatgtcct tatctggcgg tcagcagcaa   1890240
cgcctttgca ttgcgcgagc tttagcagta gaacctgata ttctgttaat ggatgagccg   1890300
acttcagcct tagaccctat ctccacttta aaaattgaag acctcattca gcaactaaaa   1890360
aaggattata cgattatcat tgttacccat aacatgcaac aagcttcacg tatttcagat   1890420
aaaactgctt ttttcttaac aggagaaatt tgcgaatttg gagataccgt tgacgtgttt   1890480
accaatccaa aagatcagcg cacagaagac tatatttcag gacggttcgg ataaggaagg   1890540
aaaaacctat gagaaatcaa tttgacttag aattgcatga attagaacaa tcctttttag   1890600
gactagggca acttgtcctt gaaacagctt caaaagcctt actggcctta gcctccaaag   1890660
acaaggagat ggcagagcta attatcaata aggatcatgc tatcaaccaa ggtcaaagcg   1890720
ctatcgaatt gacctgtgcc cgtttgttgg ccttgcagca gccacaagtg tctgaccttc   1890780
gatttgtgat tagcatcatg tcttcttgtt cagaccttga acgtatggga gaccatatgg   1890840
caggcattgc caaagctgtt ttgcaactaa aagaaaatca actagcccct gacgaagaac   1890900
agttacacca aatgggtaaa ttatccctca gcatgctagc cgatttattg gttgcctttc   1890960
ctttgcacca agcctcaaaa gctattagta ttgctcaaaa agatgaacag attgaccaat   1891020
attattatgc cttatcaaag gaaatcattg gacttatgaa agaccaagaa acctcaattc   1891080
ccaatggaac tcaatacctt tatatcatag ggcatctgga acgcttcgct gattacattg   1891140
ctaacatttg tgaacgccta gtctacctag aaacaggaga actagtggat ttgaattaat   1891200
tcaactaatc cttaaaagag aagagtacga ttaagtactc ttttttatgg ttgtaaaaaa   1891260
gttcatttga ccaatttaag cagtgtagat agtgaggagt tgtttcaatt ctatcgtgaa   1891320
cgagggaatg ctgaaaactt tatcaaagaa aggaaagcag gattctttgg ggataagaca   1891380
gatagttcga ccatgattaa gaatgaagta cgtatgatga tgggctgtct ggcttataat   1891440
ctctacctct ttttaaagca gctagctggt gatgaagtaa agtccttgac tatcaagcgt   1891500
tttcgacgtc tcttccttca tattgccgga aaatatgtct ctactgctag acgacatatt   1891560
ctcaaattct caagtctata cgcctattca aaacagtttc aagccttatt tgatacaatc   1891620
tgccagataa atctgatact ccctgttcca tatagagcta gagggcaggg gaaaacatgc   1891680
ctaacagaat aagtcacctt attttaaaaa tcgagcatca aaccaaggga ggagtctgcc   1891740
cttttttagg aaaaaatcaa gacaaatctc ctcaattatg tctcgaacat cagaaattaa   1891800
gcaaaatcac cagaaggaca gtatttcaac tagcttttct ggtaattttt gaactgtgta   1891860
gttcgttagt gccagatatg aataatttgg gatgataaat ctttcttcct caggtagcct   1891920
atcataatac tcttcaaaaa tcttatcaaa aacactctct ttcttttggg cgatagtttc   1891980
atcttcgtat gtaggagtcc tcatcaagaa atacttcaat tctaggtatt ccttatccaa   1892040
ctctatataa cttggcatca acttgtaatc ttcaaccccc aaacgttcag caatatattt   1892100
taactttgtt agtattggtc tggattctcc attttcaatt ctaattaatt gacggatact   1892160
taattcagac tcatcaccac aaaattctga acgactgatt tttttagcca aacgtaatct   1892220
tttaattttt tcgccaaact ctcgcaacct acaagaactt cctgagttgt ttacctctat   1892280
tataagcata tactgaatca aactatctat cagatttctt ctcactttaa ctaaagacta   1892340
agagtttatc ccttcgtctc ggtttttgtg tatttttcca ccatacccca gtaatgcaag   1892400
tgcaaaatcc cctagaatat gatagaataa gagaaagaac tctatcaagg aggaaatcat   1892460
ggaaaaacaa accgtcgccg tcttggggcc tggttcttgg ggaaccgccc tttcacaagt   1892520
cttaaatgac aatggacacg aggtacgtat ttggggaaat cttcccgagc aaatcaatga   1892580
aattaataca caccatacta ataagcacta ctttaaagat gtcgttctag acgaaaatat   1892640
cattgcctac accgacttag cagaaacatt gaaagatgtg gatgcgattt tgtttgttgt   1892700
cccaacaaaa gtgacacgac ttgttgccca gcaagttgca caaaccttgg accataaggt   1892760
tatcatcatg cacgcatcaa agggattaga acctgatagc cataaacgat tatcaaccat   1892820
tcttgaagaa gaaattcctg aacatctccg tagtgatatc gtcgttgttt cagggcctag   1892880
tcatgcagaa gagaccattg tgcgtgacct aactttaata actgctgctt ctaaagattt   1892940
acaaacagct caatacgttc agaagctatt tagtaatcac tacttccgac tttataccaa   1893000
tacggatgtt atcggggttg aaactgctgg tgctcttaaa aatattattg ctgtcggtgc   1893060
tggagcttta catggtcttg gatttggtga taatgctaag gcagccatca tcgctcgagg   1893120
tttagcagaa atcacccgcc taggggtagc actcggggcc agtccattga cctatagcgg   1893180
cttatctggt gtgggagatt tgatcgtaac gggaacttcc atccactctc gtaactggag   1893240
agctggagat gctctcggac gaggagaatc cctagctgat atagaagcta atatgggcat   1893300
ggtaatcgaa ggaatttcaa cgactcgagc agcctatgaa ctagcccaag aacttggagt   1893360
ctatatgccc attacacagg ctatttacca agttatttat cacggaacca atatcaaaga   1893420
tgccatttat gacatcatga acaatgaatt taaagcagaa aatgagtggt cttaaccctc   1893480
tatagaaagg atttttatga catcaaaagt tagaaaggca gtcatccctg ctgctggact   1893540
aggaactcga tttttaccag caaccaaggc ccttgccaaa gaaatgttgc caatcgtaga   1893600
caaaccaact atccagttta tcgtggaaga agctctcaaa tcaggtattg aagatattct   1893660
agttgtcact ggtaaatcaa aacgttctat tgaggaccac tttgattcaa acttcgaatt   1893720
ggaatataac ctcaaagaaa aagggaaaac agatcttttg aagctagttg ataaaacaac   1893780
tgacatgcgt ctgcatttta tccgccaaac tcatccacgc ggtctcggag atgctgtttt   1893840
gcaagccaag gctttcgtcg gaaatgaacc ttttgtcgtt atgcttggtg atgacttgat   1893900
ggatatcaca gacgaaaagg ctgttccact taccaaacaa ctcatggatg actacgagcg   1893960
tacccacgcg tctactatcg ctgtcatgcc agtccctcat gacgaagtat ctgcttacgg   1894020
ggttattgct ccgcaaggcg aaggaaaaga tggtctttac agtgttgaaa cctttgttga   1894080
aaaaccagct ccagaggacg ctcctagcga ccttgctatt atcggacgct acctcctcac   1894140
gcctgaaatt tttgagattc tcgaaaagca agctccaggt gcaggaaatg aaattcagct   1894200
gacagatgca atcgacaccc tcaataaaac acaacgtgta tttgctcgtg agttcaaagg   1894260
ggctcgttac gatgtcggag acaagtttgg cttcatgaaa acatccatcg actacgccct   1894320
caaacaccca caagtcaaag atgatttgaa gaattacctc atccaacttg gaaaagaatt   1894380
gactgagaag gaataacaaa atcatttata taaagattag ccacacataa attaagtaaa   1894440
ttctctactt gaatctacct atttaataaa aactaatgaa aacgctatac ttgtatttgt   1894500
tttttcatta aaataagagt agaataaatt agtatagtaa aacaaaaaag caccgaatcg   1894560
gtgcgcactt tttcaagttg tgtacggaca aagccttatt ttaactttgc tatgttgttt   1894620
ctaatggttc caaaataata aataatttta aatttgactt aactgttgga gtagtcatgg   1894680
ttaaattaaa tcaaccgagc cgaacataag ttgtttaatt ttgtggaagc tattaataaa   1894740
aatataataa gggagaaaga taggtgtaat tttaatttta aagtaattgc ggacactatc   1894800
aaagaaaaag attatggaga acaaatttgt agaatttatc gaaaacaata aaaaagtaat   1894860
catttcatca gttgcagttg gtgttgtatt ggtattaggg tttggatggt attcatataa   1894920
ccaacaacaa gcagaacaac aagcaaaaat tgtacaatta gaaaaagata gcaaatcaga   1894980
caaagaacaa gttgataaac tatttgaatc atttgatgca tcttcagatg aatctatttc   1895040
taaattaaaa gaactatctg aaacttcact taaaaccgat gcaggtaaag actatcttaa   1895100
taacaaagtc aaagaatcat ctaaagcaat tgtagatttt catttgcaaa aaggtttggc   1895160
ttatgatgtt aaagattcag atgacaaatt taaagataaa gcaactcttg aaacaaatgt   1895220
aaaagaaatt acaaaacaaa ttgattttat caaaaaagtt gatgaaactt ttaaacaaga   1895280
gaatttggaa gaaactctta aatctctaaa tgatcttgtt gataaatatc aaaaacaaat   1895340
cgaacttttg aagaaagaag aagaaaaagc tgctgaaaaa gctgctgaaa aagcaaagga   1895400
atcttctagt caaagtaatt cttctggtag tgcttctaat gagtcttata atggatcttc   1895460
caattcaaat gtagattata gttcatctga acaaactaat ggatattcaa ataattatgg   1895520
cggtcaagat tattctggtt caggagatag ttcaacaaat ggtggatcat cagaacaata   1895580
ttcatctagc aattcaaaca gcggagcaaa taatgtctac agatataaag gcactggtgc   1895640
tgacggctat caaagatact actacaaaga tcataataat ggagatgtgt atgatgacga   1895700
tggaaattac cttgggaact ttggtggcgg cattgcagaa cctagtcaac gctaataact   1895760
attttagagc tgtgttgttt cgaatggttc caaaacacat taaaagctac tcatttttta   1895820
agtagctttt ttcttattca agtttacata ttatactcaa tgaaaatcaa attcaaacca   1895880
cgtcagcatc gccttaccgt aggtatggtt actgacttcg tcagtttcat ctacaacctc   1895940
aaaaccatgt tttgagctga cttcgtcagt tctatctaca acctcaaagc agtgctttga   1896000
gcaacctgcg gctagcttcc tagtttgctc tttgattttc attgagtatt agtcgtcaca   1896060
atcccattcc cttgtagaaa agcaaaatgg cgagtcctac gaacaagact accgctccta   1896120
atctctggct ggtgttatac atccgttttt ctcctctaac tggaaagata actgctagaa   1896180
atgcgccacc aactgcacca ccgatatggc ctgctaggct gattcctgga atcagaacac   1896240
ttccaataat gttaaccaca aaaagtgtca gataggattg ccctagctgt tggatataag   1896300
gattgcgagt tgcatagcga agaacaataa tcgcggcaaa tagcccataa agagaggtag   1896360
aggcgcctgc tgctaaggat ttaggactaa atacaaaaac aaagagattg cccatcattc   1896420
ctgataaaag atagagaaag aaaaactgct tagaaccgaa aatctcctct acctgccttc   1896480
caagataata aagtgaaagc atattaacaa tgaaatgttc ccacccaata tgaacaaaaa   1896540
tggcagacaa gagacgccaa acctgctcgg gaaagaggcg aatagctggc ccatacatgg   1896600
ctccaaatcg aaataatgta tctgccctgt caaagtttcc gcctgcagtg accaacatta   1896660
gtaaaaatac caaggccgtc actaagagga agaaactcgt cacagggtaa cgtctatcaa   1896720
agatttcctt catcaattaa tacctcctga acaggaatat catggttttc aggtataaag   1896780
tcctgaattt gacaaggata tatcgtactc aaagtacgac cagaaaaatg ttccagatag   1896840
cggtcataat agcctccacc gtatcctatc cgatatcctt tcgtcgtaaa agccagacca   1896900
ggaacatgaa tcaaatcaat ctgagatgca tccaccactt ccaaatctcc ctgtagctcc   1896960
agtaaggcaa agaaagtttt taccaactgt tgcggatcat agaccacaaa gtccatgcgc   1897020
cccttgggat aagttttggg tattaaaacc ttcttgccgt ccttcagcgc ctgctcaatc   1897080
agttcctgcg tttgaaactc atgagaaaaa gagaggtagg ttgcgatgac cttggcttct   1897140
tgataaaagg ggtgttgtaa aagccgctcg gttaaagctt ggtctatagc ctgtttttgc   1897200
tcttgagata tagccttcat ttcatgcaag acttgcttgc gtaattccga tttcatagac   1897260
aagccctcta ttctgctgcc ttctttttca ggaaactaga caccgcagcc accccaatag   1897320
ctaagacttc ttccttagga ctcatttgag ggtgatgaag agcgtaggga ctatcgatac   1897380
ctagccaaaa catcacgcca tcaacctttg aaaggagata accaaagtcc tcgcctgtca   1897440
tagcaggttc gatatcaatc aactcgattc cgtctttttc gtcaaagaag tccatcagtt   1897500
cacgcgccaa ggctggattg ttctcaacag gtaggtatcc accttgtttg agttccactt   1897560
cgacttccat atcaaaggca gctgcaaccc cttctgcaac tgtttttacc ctcttttgca   1897620
ccaagagact catgtcctgt gtcaaggcac gaatagttcc atgtaaaaaa gctgtgtctg   1897680
tgatgacatt gttggtggtt ccagcttgaa aaacgccgaa ggtcaccact gctccctcga   1897740
ttgggttgac attgcggcta acaactgact gcacttgggt cacaaagtaa ctagccgcca   1897800
ccaaggcgtc attggcttca tgaggaaaag ctgcgtggcc acctttgcct ttgaaacgga   1897860
tcttcacctc gcaagttcct gcaaagagtg tatgagtatt agtcgcaatc tggccgactt   1897920
tcaaatctgg acgaacatgg agaccataga attgatctgg caaccaatct ccaaaagcac   1897980
cgtcctcata catgagcata ccaccagctt cattttcttc agcaggctga aatagaaaga   1898040
gcagattatt cttgggttgc tcctcaaggg cgcgctcaag acagcctaag gcaatggtca   1898100
tatgaaaatc atggacacag gcatgcatgc gaccttggtg ttgagaagca aaaggtagac   1898160
ctgtttgttc gacgataggc aggccatcaa tatctgtccg ccaaccaatg gttcgctccg   1898220
gctgacttcc ctgcaggtag accaaaatcc ctgtccgcca agtacgaatt tgaacaaaat   1898280
ccttgcccgt agtcaatttc tcaatcacat ccagcaaata agcctgagtc ttgaactcct   1898340
ccaagccaat ctctggaatc tggtgtaaat ctcgtctagt ctgaatcaaa tctaacatct   1898400
atctgtcctc cgatatagca gaaagaggct ggaaaaaggg ttccgcctct tttttacttt   1898460
tacaattaca aggtacgaag cgcatcctct agcgctgttt tttgttgagt ttgggcatca   1898520
atttctttga taatacgagc tggaacacct gctactacca cgttttctgg gacatcttgg   1898580
gtaacaatag ctcctgctgc gacaactgaa ccactaccga tttggactcc ttcgataacc   1898640
actgcattag caccgataag aacattgtct ccgacacgga ctggttcagc actagctggc   1898700
tcaatcacac ctgccaaaac tgcacctgca ccaacgtggc tattttttcc aacgatggca   1898760
cggccaccaa ggatggcacc catgtcaatc atggttccag caccgatttc agcaccgata   1898820
ttgataacag atcccatcat gataacagca ttgtcaccaa tttccacctg gtcacggata   1898880
atcgcacctg gctcgatacg agcgttgata gcacgcttat ctagcaaagg aactgcagaa   1898940
ttacgagcat cttgctcgac aacataatct tgattttcta ccaaaccttc aagaagcgga   1899000
gccacatcct tccagtctcc gaataggaca tttcctagtt tgacaacaga gctaggcaca   1899060
gcagttgcga gttgcccctc aaaggttact ttgacactgg ttttcttttc agcattggcg   1899120
ataaattgga taatttcttg agcgttcatt tttgtagcag tcataggtgc ctcctggttc   1899180
gttataatga tacctattct accaaaaaag gcctcaaatt tgaaaccttt ttgtctgttt   1899240
ttaggtatga ttttttaggg atgtgagata aaacgtgctg tcggtaaaag caagccccta   1899300
ccgatacaac ctaaaaacac tcttcacaac tatctccccg tgttttattg actattccag   1899360
tatagcacac ttttagaatt aagaaaagac tttttatcta ctttctttcg cttcttctat   1899420
agacaaaaat atcatgggta aaataatcaa ggctatagct agaaggaggg accaatccac   1899480
tactaatcct aagaacaaaa cactcaagag agcagaagag agaggttcac tggcactgat   1899540
aacggcaacc accaaaggag aaaccaagga cacagccttc atggaaatga aaaaagcaaa   1899600
agccgttcca aagaaagcga taatgaggca aatcaagata ctccaaatat caagagtaaa   1899660
ggaaagctga taaaccggcg agaggacatt gctaaacaaa cctgccaaaa tcatccccca   1899720
cccaaccgta ggaacaaaac cataacgctt agcaaaaggt tggggcaaga taacattaaa   1899780
cataacaccc atggcactca gcaaacctgt tataagagct agcggcgtca tggataactg   1899840
agagaggtct ccctttgtcg ccatcaagca aacacccagc atggcaacca aaacatagaa   1899900
aacagcgctt tttgacgctc gtttttgata aaccaagcga ttgtaaaaga ggataaagac   1899960
agggctaata aactgtaaaa tagttgctgt cgtagcattt gagtattcta cacagagata   1900020
gaaaaaatac tgaactgaaa aaatccccaa aatagcatag gctaaaaagg gcaggtaatt   1900080
tttcttgtct cgccaaatat ctagcacttg cgattttaat tgtattgcag accaaatgag   1900140
tacaagactc cctgccagtg tcaaacgcat agaggtaatc cagcccgaag acacctgata   1900200
atgagtaaag aagtactctc ctaaaattcc acagattccc catattaagc cggataggag   1900260
cgaataaatt tttccgttaa caatcttttt ctgatactga ttcataccct tattgtaaca   1900320
cgaaaggaaa aaagtggcaa tccattgatt ggccacttca tttagagaat tatcgtctcg   1900380
cccttgaaga agaaggtcgt gtagtacttg agttactgct atcgctagaa ctactacttg   1900440
aactgctgga gctggatgga gttggtagac tccccacaat actagaccaa gcattctgat   1900500
aatccgcatc acttccgcca atagcaaagc gataacttgt cgctggcgct cctgacttat   1900560
tagcccaata gctggtaaca gtcgaacctg tgacctctac ttcttttcct tcaacagaaa   1900620
ccttctctgg tttttgacct gttgatttca agacttccga tttcactaca ctaggatcta   1900680
aagcaaagcg ctcgttcccc caaatgcttg gggaagcttg ctgaatcgca tttaccagat   1900740
gagccatgta attagagtta ttagaataac ctgctctacg tgacaatgaa tgattatcat   1900800
catgcccaat ccagccacct agggttaatc taggtgtcga aagcatgagc cacatatttt   1900860
cgtcttggtt ggttgtacca gtcttcccaa tccaatctgc attagccaga gtaggattta   1900920
aagaagtcag gttagacttg aaggttgttg tcacacgaga ggatagaact tctcgtagca   1900980
atccctgcat aatcgtcgca gtagcttttg aatagacttg aaccggttta tcctgatact   1901040
catacaccac tctaccatct gctgcttcaa tctttgaaat cacatgcttc tgatgataaa   1901100
ctccattatt agctaaggtc tgatagccat tggtatgctg ggcaactgtg acttcaatac   1901160
caccacccat tggcaagctc tcaataccgt actcaggaat ctcgtaaccc atcttttcca   1901220
tataaccctt gacatcaaca cccttttcac ggagcatacg ataggtccag taagcaggga   1901280
tattccatga atagttcaga gcttctccca aggtcatcat tcctgttccc ttgctattag   1901340
catacataat cggattgcca ttagcaaagt ttgttggata gttagataga atcgtttcac   1901400
ttcccatcaa gccctggtca atagcaatac cgtaggccag caagggcttg gtagtagaag   1901460
ctggcgaacg tttggtatca aaggcatgat tattttgatt ttcttgataa ttacgaccac   1901520
ctacaaagcc tagaatagca cctgtttggt tatccatcaa gacattccct acttctacac   1901580
gacctgttcc atcgtctaaa agatagccat aatcagcaac cgcactttgc atggcagaat   1901640
gaattttctg atctatggta gtagtaatct tataaccacc attttcaatt tccttggctg   1901700
ccaaatctcg ataaaacttc tgagttgcct catttttcaa ctccttagcg gagacattgt   1901760
ctctctgagc tagatagtca tacatacgtt cttgagcttc tgccaaagtt gtaaagtata   1901820
aatagtctcg tgaaattcct gtaaccgtgc ccgatggtaa aaagtcctgt ttaaggtcat   1901880
aatccttgta ctgagaatac tcgtctttgc ttaatgcacc tgtacgatac atactgtaaa   1901940
gaactgcctt agcccgtctt aagccaattt ctaggtcttc atcactcttc aactccccag   1902000
tattttcata aggagagtaa gtaatgggac tctgtggaag tcctgctaaa aatgctgctt   1902060
gaggaacagt caactgactg gcatctacac cgaaaattcc ctcagctgct tgccgagccc   1902120
ctgcaatatt ctgtccctta ttatttcggc caaagggagc cacattgaga taggtcgtta   1902180
aaatctcatc tttattcatg gcgcgttcca aggcaagagc atccacaatc tctgccgcct   1902240
tacgagccaa ggtcggcgca tccccaacca cctgctgttt aattagttgc tgggtcaagg   1902300
ttgaaccccc actagaggaa cccaaaccta caaatttccc caaggtcgca cgaatcaccg   1902360
ccttgggtac tacaccctta tgttctttaa agtgttcatc ttctgtcgca atgatagcct   1902420
tcttcagatt ttccgaaatt tgctcagatg agatagaagt gcgcaacaaa tcactctcta   1902480
tggaagcaat caccgtcccg tccgaatagg taatctctga aatagaagag atgtccttga   1902540
cctgattcac caattcttct gtctgaggca cccgaacctt gtcaaataag gccactccgt   1902600
atcccaaagc aatcccagct cccaacattc ctcctagaaa accgagtaca aagagtaagt   1902660
taaataaggc ttttatactc agtaaaatag ctgggaaaat gactgactta tctaaggttt   1902720
tagatttttt ggtacttgaa cctttcttgc caggtctagc tgatttttta tttttttgtt   1902780
tttgctggaa aaattccagc atttttcgtt ttaattcatt taattgattt tgcatggatt   1902840
tcctcacttt atctattata ccacaaaagg gaaattttca ataaaatagc cactttcttc   1902900
cctattctgc taggctattg cccaagtttg tgatacaata ggtagaaaca ataattttaa   1902960
aaaggagaaa aaacacatgc acatttttga tgagctaaaa gagcgtggtt tgatatttca   1903020
aacgactgat gaagaagctt tgcgtaaagc cctagaagaa ggtcaagttt cttattatac   1903080
tggctacgat ccaactgctg acagccttca cctaggccac cttgtcgcaa tcttgacaag   1903140
tcgtcgcttg caactagcag gtcacaaacc ttatgcgctc gttggcggtg ctacaggtct   1903200
catcggagat ccgtccttca aagatgctga acgtagtctc caaacaaaag acacagtaga   1903260
tggctgggtc aagtctatcc aaggacaact ttctcgtttt cttgactttg aaaatggcga   1903320
aaacaaggct gtcatggtca acaactacga ctggtttggc agcatcagct tcattgactt   1903380
cctccgtgat attggaaaat acttcacggt caactacatg atgagtaagg aatctgttaa   1903440
aaaacggatc gaaacaggaa tttcttacac tgagttcgct taccaaatca tgcaagggta   1903500
tgacttcttc gtccttaacc aagaccataa tgtcactctt caaatcggtg gttctgacca   1903560
gtggggaaat atgacagctg gtaccgaatt gcttcgtcgt aaggcggaca agactggtca   1903620
cgttatcact gttccactaa tcacagatgc aactggtaag aaatttggta aatcagaagg   1903680
aaatgccgtc tggctcaatc ccgaaaagac ttctccatac gaaatgtacc aattctggat   1903740
gaacgtgatg gacgctgacg ctgttcgctt cttgaaaatc tttactttct tgtcacttga   1903800
tgagattgaa gatattcgta aacaatttga agcagcgcca cacgaacgct tggctcaaaa   1903860
agtcttggct cgtgaagttg ttacacttgt tcacggagaa gaagcctaca aagaagcact   1903920
taacatcact gagcaactct ttgcaggaaa catcaaaaac ctttctgtca aagagctcaa   1903980
acaaggactt cgtggtgtgc ccaactacca agtacaggca gacgaaaaca acaatatcgt   1904040
ggaactgctc gtctcatctg gtatagttaa ctcaaaacgc caagcccgtg aagacgtcca   1904100
aaacggagcc atctacgtaa acggcgaccg catccaagag cttgactatg tcttgagtga   1904160
cgctgataag ttagagaatg aactgactgt tatccgtcgt gggaagaaaa aatactttgt   1904220
attgacttac taaactattc aacatttatc tataaacaaa ggagttaacc tcgagaaagg   1904280
taactccttt ttgctgttaa taactctcat ctatctattt ttaatagaca ggctacgcag   1904340
gacaatgcgc aaggttgtta gattatgtaa gatagagaga tttgaaggac tgaaccaatt   1904400
aaataagcca aagccaatca aactactatt tacgacaacg gtatcctgaa tatttttctt   1904460
gatgagtgtt tgcaaagatg atgataacga atccaactct tggaagaaat ccaaacgatt   1904520
atctaacaat aagatatcac tcatctgctt agaaatatct gcactctcat tcatcaccac   1904580
accgatatct gatagagtta aagccgctga gtcattcaat ccatctccaa ccatcaaaat   1904640
agtgtgacct gctttctgca gtttctctac taactcaaat ttcccatcag gtttcaagtc   1904700
tgtatagacc tgatcaaagg gcaaatcttt gactaattcc tctgtcctaa tcaaggtgtc   1904760
tcctgttgcc agaatcaatt ttttcccctg tgccttaagt ttatccaagg ctgtttttgc   1904820
ttcttttctc aaaggagtat gaatgcagaa cattccaatc aattcatttt gataagccaa   1904880
gaataagaga ttgtagtgac tcttgtactc ttcaattaaa gcattttgtt ctgaactgat   1904940
atgaatctgc tcatcctgca tcaagacata attcccaata agaactggtt ggccatctat   1905000
atgagatttg atccccttgc ttgcgatata ttggagtttc ccatgcattt cctcatgttc   1905060
aattccctct atctcagctt gcttgacgat ggcattagca ataggatgat aaatgtgttc   1905120
ctcaagacag gcactgattc tgagaatatc ttcctcacta tagtctccaa aaggtaacac   1905180
cttttcaact ataggataac tagttgtgat tgttcctgtc ttatcaaaca agaaagtatc   1905240
aacttccaga tatttctcca gaacatctcc atccttaatc accatttcac ggttcaaccc   1905300
ttccttgata actgtcaaat aagctacagg agtagagatt ttcaaagcgc aggagaaatc   1905360
gaccaatagg aaagaaatag ccttagaaaa agaacctgtc aataggtaag tcagcccagc   1905420
ccccaagaaa ttatatttga cgactttatc cgccatcttg atgaaatagc gttgtttcgt   1905480
tttcttgttt tcttcagatt tcttcatcaa ctcaatcagc tgtaaaatac ggctgttcat   1905540
ctgattatct gttacacgaa tgcgtaactc tccagtttct aatactgtat ttgcacaaac   1905600
caaatcagac tctctttttt caactggaaa actctctcct gtcaaggaac tttcgttgac   1905660
catacctaaa cctgaaacta cttgtccatc aaacagaatt tcatttcctt gagataagat   1905720
caagacatct cctatttgaa catcggaact cttgatacta acaaccgtat cgccctgtac   1905780
taggaataca tcgctctctt ttgcaagaag actctgttct aaatctgttg cagttttttt   1905840
caaggaccac tgatctaaat gattccccaa atcaagcata aacatgatat tgctagctgt   1905900
cttggattgg ttcataaaca aagacaataa aatagccgaa cagtccaaga cttccatcgt   1905960
tagttcctta cgcgctagtg tttgataggc ttctctaata taacccaaag cctgataaca   1906020
agtccatata tagcgaatag gatacggcac aaaactacga aaaagtacac gcttaaccgc   1906080
tgcacctgaa acaatagaat aagcactctc ttctctacga atgggaagag tcatcaactc   1906140
agaaactttc cctttatcaa ttctttttaa aaaggcttct gcattatcta atacagaaaa   1906200
gccttctttt atgcgtagag taaagtgctg ttgatccatg taaaactgga tagactcaat   1906260
ccccttttca tctctcgcca aggaacgaag atagtcttga atatccaagg taagtgaaaa   1906320
agaagatgat agtcggatat gttggtatcc tctatgtagc actttaaaag acatattatt   1906380
cacctataag gctatctaat tgctcttctt ttttctcttg ctcgtacaaa tatttggcat   1906440
cttgcaagac atcgtctcca tgttgcttca caacagaaac agatgcatct agctcgtctt   1906500
tcaacttgta agccttagcc aaagctttag aataaccttt tttagcttcc ttacttgcta   1906560
agattttcaa accaagggta ccaaatgcga caccacccaa aaataatgaa gattttttcg   1906620
caacttttgc aacggttaat acttctttta acatacttat ttcctcctta tcattattat   1906680
atagcaattt agatataaaa gcaatttcat tctataaatt ggagaattag ttttatttct   1906740
actgaatctc ccatctactt attcctaaag ttgctttcat ttgcctcttt tgatacactt   1906800
aaactatgaa tacaaatctc aagcccaaac ttcagcgttt tgcttctgcg actgcctttg   1906860
cctgtcctat ctgtcaagaa aatctgactc tgttagagac taatttcaag tgctgcaacc   1906920
gtcattcttt tgacttggcg aaatttggct atgtcaatct agtccctcaa atcaagcaat   1906980
ctgctaacta cgacaaggaa aattttcaaa accgtcaaca aatcctagaa gccggctttt   1907040
accaagctat cttagatgct gtatctgact tgcttgcaag ctcaaaaact accacaacaa   1907100
ttttggatat cggttgtggt gaaggattct attctcgcaa actacaagaa agtcactctg   1907160
aaaaaacttt ctatgccttt gacatctcca aagattcagt ccaaatcgct gctaaaagtg   1907220
aacccaactg ggcagtcaat tggttcgttg gcgacttggc acgacttcct ataaagacgc   1907280
taacatggat attctgcttg atatcttctc acctgccaac tatggagaat ttcgtcgcgt   1907340
tttatccaaa gacggtatct tgataaaggt tatcccaact gaaaatcacc tcaaagaaat   1907400
ccgtcaaaga gtacaggacc agctgacaaa caaggagtat tctaaccaag atatcaagga   1907460
gcatttccag gaacacttta ccatcctatc tagtcaaact gcctctctga ctaagactat   1907520
cacagcagaa caactccaag ccctactcag tatgactcct ctcctctttc acgttgacca   1907580
gagcaaaatt gactggagca aactgacaga gattaccatc gaagcagaga ttttggttgg   1907640
gaaagcattc taatactctt caaaccacgt caacgtcgcc ttgccgtacg tatggttact   1907700
gacttcgtca gtttcatcta caacctcaaa accatgtttt gagctgactt cgtcagtttt   1907760
atctgcaacc tcaaagctgt actttgagca acctacggct agtttactct ttgattttca   1907820
ttgagtataa actagacttc gcaaaagtag aaaacttacc gaaaatcttc aatatgacaa   1907880
aaacgtataa gaacaggtac acaaacctta atcttatgcg ttttgttata gtttccatac   1907940
acattaaggg gaaatagttg aaatcagttc ttttaataac cattgaatac catatactac   1908000
atttacccca aatatgatat aggccgtata aatcaagtat ttcgattttt cccgcctcaa   1908060
agaatagatc ttatacaaaa taaataaatt taaaataata aataatagag acaaaatctt   1908120
cctccaaaat aaatcctaaa agtacacagt caagcatagc tctaatcttt attttcgatt   1908180
cgatataaca aacttatcaa tgaatagtaa gtgatataag gccagtacca gaccccaaac   1908240
gctaccacga aaagagaatt cttgatgatt gagagtaaac aaatcatggt taccaatata   1908300
gaggcaggtc aaaataacaa ataaaatcca aaataaatcc gtccatttat attttgaaaa   1908360
atattttttt aacataatag catatttttt tgactataat aacagtatat gataaaatgt   1908420
aagcagatgc aaataaaaag gagaaaagct catgaacaaa ttaatgaaat ttatttcggt   1908480
ttttttgacg tcaattgtgt taattgtatc agcgattcca agtgtttcag ctgtatacgc   1908540
ttctgaacaa gtatcacaaa ttgaaacaaa tatggaactt caacctgtca cttctctaac   1908600
agaagaacaa atcaatacac ttgcaaacga aatccaatct tttcatccag acgtctcaca   1908660
acaatggatc aaagaagtaa ttaaccgaca attacaaggc gattatacaa tcccacctac   1908720
atactctcca tttagagcag tttggcaagg tattacagtt aatcaaatgg gtgctctatt   1908780
agatactgca atagctttag cattaggagg aactactgca ggccttgcaa atctaattaa   1908840
agtaaaagga aaacatgcag caaaaagtgc tattcgttca gcaatttcta gatatctagg   1908900
tagttggttt gtaaatgatg ttgctttaga attcgctatg aatttattat caccggggac   1908960
ttatttagca caattatggg ataaaaatga tgccattcct aacaacggaa ggattaactt   1909020
ttaatcatga gatatacaat aaaattaatt gggtataacg tattttcgtt gtttatattc   1909080
tttatcttat caatgttgtt taaagttccc tttaggtggt ggatcagcat tgcaatgacg   1909140
acttcgtcgt acattgtata taattactta aagaaaaaga gagaaaagga atgatcttat   1909200
accagatcat tccttttctg ctttctgtaa acccctcgga gtgtgtttgg cgctttgata   1909260
cgaagtgtca aagctgtata aacgttacta tttccaaaaa agtaacagaa aattcctgct   1909320
ttgtaggact gctttgggtg agtaatagac atgtcgactc accctatctc ctgatggcga   1909380
aaagaattta gcaatggtgc aagttgttct gaactcgaga aaaaacatgc cgaaatcgaa   1909440
gaaaagcgtg cagaacttga agcgaagaag caagaaatgt tgaatcgctt ggataaatag   1909500
aatttagaaa acagaaaaaa ctaaaaagaa tgtagggttt atttccctac attcttaaaa   1909560
taacttagta cataaatgac aatgctgcca ctgccgtcaa tattgcaaaa actattttcc   1909620
aaattttttt attttttcca aaaatcttat caggtaacaa gcttattaca agaaaggtaa   1909680
taaacaacac caatttaagt gtgtatatca taaaaacacc ttctttccta caattatatt   1909740
ataatacttt atgtaagcga atataataga tatgaggtaa ccaactacga aaaaatataa   1909800
ggctgaggac agtaaaaacc agcatttaaa gccttcactg tatctaggat ttccctattt   1909860
ttagacaaga ttgacccaaa tctacatcat taaaaaagcg aatttcaatc gaaactcgct   1909920
tttttacaaa atgtattagt ataaatttgt atcttatact caatgaaaat caaagagcaa   1909980
actaggaagc tagccgcagt tgctcaaagc actgctttga ggttgcagat aaagctgacg   1910040
tggtttgaag agattttcga agagtattag ttcaagtgcc agatgtcttc gttatactga   1910100
gcgattgtac ggtcagatga gaagaatcct gctttagaaa tgttaacgat gactttatcc   1910160
aaccatgcgt cacggtcttc gtagtcagca agcatttgct ctttgacttt gatgtagtct   1910220
tccaaatcaa gaagagtcat gaaccagtct ttgttgatca attcattgta aaaacgttcc   1910280
aagcgctctt tgtttccagc tgcaagaact gcatcactaa cgatgaagtc aaccaatggt   1910340
ttgatagctt cacgagcgta gaattcgctt gatttgtaag ctgcttttgc gtaaaggtcg   1910400
ataacagttt ctgaatcttc accgaagatg tagatgtttt cttctccaac caactcagcg   1910460
atttccacgt tagcaccgtc catagtacca agtgtcaaag ctccgttcaa catgaatttc   1910520
atgttaccag tacctgaagc ttctttagaa gcaagtgaga tttgttctga gatatcacat   1910580
gctgggataa ggaaacttgc tgcagtaacg ttgtagtttt caaccataac tacttgcaag   1910640
tgtggagcta ctgctggatc gttagcaata acttctgaca tgcaaaggat taaatggata   1910700
atgtcttgag cgattgtgta ggctggagct gctttaccac caaagaagat tgtgattgga   1910760
cgagcaggga tgttaccagc tttgatgtca aggtatttgt ggatcacgta caaagcgttc   1910820
atttgttggc gtttgtactc gtgaagacgt ttgatttgga tatcaaagat agaatttgga   1910880
ttgatttcca caccttggtg ttctttcaag tgacgagcca atttacgttt gttgtgagcc   1910940
ttgatgcttt ccaatttttc tttgacaact gctttgtctt cataagacaa aagtttttca   1911000
agctcatctg cttcatggtg ccaaccatct ccaagaatct catccaagta gtgagacaat   1911060
cttgggttag catgcataag ccaacgacgg aaagtgatac cgtttgtttt gttgttgaac   1911120
ttttctgggt aaaggtcgta gaaggctttc aactcagaat ttttcaagat ttcagtatgg   1911180
agtgctgcaa ccccgttaac actgtatccg tagtggatat ccatgtgagc catgtgaaca   1911240
cgtccgctct catcgatgat ttgaacagct ggatctttgt actctgcctt cacacgacgg   1911300
tccaattctt cgatgattgg taccaagtga ggaaccactt cttgcaagaa ttcaagaggc   1911360
catttttcaa gcgcttcagc aaggattgtg tggttagtgt aggcagtcat gctacgaaca   1911420
attgagattg cttcgtcaag atcgatacca cgtgcagtca aaagacgaat caattcagga   1911480
atcaccattg atgggtgagt atcgttgatt tggacaactg cgtagtcagc aaggtcatgc   1911540
aagttgcttc ctttttcgat tgcttcgtcg atgatcaatt gcgcaccgtt tgaaaccatg   1911600
aagtattgtt ggaagatacg gagcaattca ccttgacggt cactatcatc tgggtaaagg   1911660
aagagagtta agttgcgagc gatatctgtc ttgtcaaagt tgataccatc tttaataata   1911720
gaagaatcaa ctgaatccaa gtcaaacaaa cgcaagcggt ttttagtcgc tgtttcataa   1911780
ccagtaacat caatatcgta aagagttgat gtcaaagtaa agtctgcaaa tggtacttgg   1911840
tagctacggc ttgagcgaac caaccagttt tgctctgtca accatgcatt tggaattgtt   1911900
tcttgttggt tgtttttaag aacttgttgg aaaagaccaa agtggtagtt aagaccaaca   1911960
ccgtcaccat tcaaaccaag agtagcaatt gagtcgataa agcaggcagc caaacgtccc   1912020
aaaccaccat taccaagaga tggttccaat tcaacttctt caacttcgat caagtcttta   1912080
cctgcagctg caagttcttt tttaacatcg tcgtaaagac caaggttaat caagttgttt   1912140
gacaagagtt taccaatcaa gaactcagct gagatgtagt aaactttttt cttaccagtg   1912200
ttgactggtt tttggctgct tgcaagcttg ctgtagttaa gaagagcaag gtaaagctct   1912260
tcattgctac attctgcaat ggttttattg taacgatttt gtacaaattc ttgtagtgat   1912320
aacatgttta gttgtctcct gattattgtc ttatttcttt aaatctacca aattttcatt   1912380
aattcggcga taaattgttg tcaagtcaag caaaccttcc tcgacagctg gtgtcaattg   1912440
atcttcagtc atacgccaag accagtttcc accaagggta gatgggaagt tcatacgagc   1912500
tgcctcatcc aattctagta aatcttgcat agttgcaatt gccataaagc taactgatga   1912560
aaatactgta cgaagcatag cgtgtaccac tgtttcgtat tctttacggt tcgtgtaacg   1912620
agccatgtac tcacgagtcg catcatcaat ctcattacgg taccaaccaa gaaccgtatt   1912680
gttatcgtgt gttcctgtgt acataactga gttagcaggt gccaagtgtg ggctatcaat   1912740
gctttcgtct tctgggttga aggcaaattg aagaatcttc attcctggga agccagtacg   1912800
ttcacgcaat tcgatcactt catctgtcat gaagccaagg tcttctgcga tgatgtttag   1912860
ctcaccaagt tcttccttaa cggctgcaaa aagcttgtaa cctggacctt tcacccactc   1912920
accaggtgct gctgtatcgg aaccagcagg gatttcccag taagattcga agccacggaa   1912980
gtggtcgata cgaacgatat cgtagatttt gaagctttca cgcaagcgtt caatccacca   1913040
tttgtagccg tctttgtcca ttgcttccca gtcatagatt ggattacccc aaagctgacc   1913100
agttacagaa aactcatctg gtgggcatcc tgcgatacaa gtagccttac cattgacatc   1913160
tgttttgaag agatgtggat ttgcccacat atcacttgaa tcttccgcta cgtagattgg   1913220
catgtcccca acgatttcga tgtggttgtc gttagcgtaa gctttcaatt tcaaccattg   1913280
ttggaagaag aagtattgag tcacacggtg gtaaaccaac ttgtctgcca attgctcacg   1913340
atagctttca agtgctgaag ctttacgagc acgagcatct gcatctggcc attcagtcca   1913400
agcaagattg tcaaaatact ctttgatagc catatactca gcaaagagct caagccatga   1913460
ttggttgtct tgagcaaatt tctcaaaatc tttaacatct ccgacttcaa agaaacgttt   1913520
caccgctttt tctaaaagag gacgacgtgc atagtagatt ttagcatagt caacttcaga   1913580
cgcatcgcta ccaaagtcaa ctccttcaag gtcacttgct tccaacaaac cttgctccac   1913640
caagatatct aaatcgataa aatgagtgtt tcctgcgaag gctgagaaag attggtaagg   1913700
agaatccccg taactagttg ctcctaatgg aaggatttgc cagtaacgtt gttttgtacg   1913760
gaccaagaaa tcaacgaagt cgtaagcact ttgaccaaat gatccgattc cgtaagctcc   1913820
tggaagagaa gagatgtgca tcaacacacc actttgacgt tttttcataa tagcacctcg   1913880
tgtgttaaaa taatggaacg ttgcgtattt ttcagacgca aacgtttgcg ttacttataa   1913940
gtatactcct tttcaagcat aattgcaagc gtttttaaaa aacttttttg attattttta   1914000
aggagactaa ctcattttag caaagataac ttaaaactat ctaatcctaa agtttgactc   1914060
tcacgagaca gtatacaaag tacaaaacct ccttagggag cttgaattta tatgcaacaa   1914120
agcacaaacg tctatagaaa atagatatag attagaaata ggaaggtagc ccctcctgat   1914180
ttccctcttt agacagattt catatatttt tattaaaaat actgtattct tatctatttc   1914240
atacttttct tctattaaaa tgcaaaatta tgctatcaaa tcaagcttaa aaatttttta   1914300
aaatttttac aaaaaatact tgcaaccgtt ttctatttgt gctatactaa gctcataaag   1914360
gaaaacgttt gcgtttcctt atcaataaaa cttgctattc tttaggagga atacactatg   1914420
tcatctaaat ttatgaagag cgctgcggtg cttggaactg ctacacttgc tagcttgctt   1914480
ttggtagctt gcggaagcaa aactgctgat aagcctgctg attctggttc atctgaagtc   1914540
aaagaactca ctgtatatgt agacgaggga tataagagct atattgaaga ggttgctaaa   1914600
gcttatgaaa aagaagctgg agtaaaagtc actcttaaaa ctggtgatgc tctaggaggt   1914660
cttgataaac tttctcttga caaccaatct ggtaatgtcc ctgatgttat gatggctcca   1914720
tacgaccgtg taggtagcct tggttctgac ggacaacttt cagaagtgaa attgagcgat   1914780
ggtgctaaaa cagacgacac aactaaatct cttgtaacag ctgctaatgg taaagtttac   1914840
ggtgctcctg ccgttatcga gtcacttgtt atgtactaca acaaagactt ggtgaaagat   1914900
gctccaaaaa catttgctga cttggaaaac cttgctaaag atagcaaata cgcattcgct   1914960
ggtgaagatg gtaaaactac tgccttccta gctgactgga caaacttcta ctatacatat   1915020
ggacttcttg ccggtaacgg tgcttacgtc tttggccaaa acggtaaaga cgctaaagac   1915080
atcggtcttg caaacgacgg ttctatcgta ggtatcaact acgctaaatc ttggtacgaa   1915140
aaatggccta aaggtatgca agatacagaa ggtgctggaa acttaatcca aactcaattc   1915200
caagaaggta aaacagctgc tatcatcgac ggaccttgga aagctcaagc ctttaaagat   1915260
gctaaagtaa actacggagt tgcaactatc ccaactcttc caaatggaaa agaatatgct   1915320
gcattcggtg gtggtaaagc ttgggtcatt cctcaagccg ttaagaacct tgaagcttct   1915380
caaaaatttg tagacttcct tgttgcaact gaacaacaaa aagtattata tgataagact   1915440
aacgaaatcc cagctaatac tgaggctcgt tcatacgctg aaggtaaaaa cgatgagttg   1915500
acaacagctg ttatcaaaca gttcaagaac actcaaccac tgccaaacat ctctcaaatg   1915560
tctgcagttt gggatccagc gaaaaatatg ctctttgatg ctgtaagtgg tcaaaaagat   1915620
gctaaaacag ctgctaacga tgctgtaaca ttgatcaaag aaacaatcaa acaaaaattt   1915680
ggtgaataaa aaatttgttc aaggggggtg gaaatcaaat ccccctttga atttatcaat   1915740
agagacacaa ataatttagc tttcttataa aaaagtagta tcctatgaaa ggagttaata   1915800
tggaaaagca acaacctagt aaagcagccc tgctgtctat cattcctggg ttaggacaga   1915860
tttacaataa acaaaaagcc aaaggtttta tcttccttgg tgtaaccatc gtatttgtcc   1915920
tttacttcct agcacttgca acccctgaat tgagcaacct catcactctt ggtgacaaac   1915980
caggtcgtga taattccctc tttatgctga ttcgtggtgc cttccatcta atctttgtaa   1916040
tcgtttatgt actcttttat ttctcaaata tcaaagatgc acatacgatt gcaaaacgca   1916100
ttaacaatgg aattccagtt ccacgcacac tcaaagacat gatcaaaggg atttatgaaa   1916160
atggcttccc ttacctcttg atcattccat cttatgttgc catgaccttc gcgattatct   1916220
tcccagttat cgtaaccttg atgatcgcct ttaccaacta cgacttccaa cacttgccac   1916280
caaacaagtt gttggactgg gttggtttga ccaactttac aaacatttgg agcttgagta   1916340
ccttccgttc tgcctttggt tctgttcttt cttggactat catttgggct ttggcagctt   1916400
ctactttaca aatcgtaatt ggtatcttca cagctatcat tgccaaccaa ccatttatca   1916460
aaggaaaacg tatctttggt gttattttcc ttcttccttg ggctgtccca gccttcatca   1916520
ctatcttgac attctcaaac atgtttaacg atagtgtcgg tgctatcaac actcaagtat   1916580
tgccaatctt ggctaaattc cttcctttcc ttgatggagc tcttattcct tggaaaacag   1916640
acccaacttg gactaagatt gccttgatta tgatgcaagg ttggctcgga ttcccataca   1916700
tctacgttct gaccttgggt atcttgcaat ctattcctaa cgacctttac gaagcagctt   1916760
atattgacgg tgccaacgct tggcaaaaat tccgcaacat cactttccca atgattttgg   1916820
ctgttgcggc acctactttg attagccaat acaccttcaa ctttaacaac ttctctatca   1916880
tgtacctctt caatggtgga ggacctggta gtgtcggagg tggagctggt tcaaccgata   1916940
tcttgatctc atggatctac cgtttgacaa caggtacatc tcctcaatac tcaatggcgg   1917000
cagctgttac cttgattatc tctatcattg tcatctcaat ctctatgatc gcattcaaga   1917060
aactacacgc atttgatatg gaggacgtct aagatgaata actcaattaa actcaaacgt   1917120
agactgactc aaagccttac ttacctttac ctgattggtc tatcaattgt aattatctat   1917180
ccactgttga ttaccattat gtcagccttt aaagcaggta acgtctcagc ctttaaacta   1917240
gatactaata tcgacctcaa ttttgataac tttaaaggcc tcttcactga aaccttgtac   1917300
ggtacttggt acctcaacac tttgattatc gccttaatta ccatggctgt tcaaacaagt   1917360
atcatcgtac ttgctggtta tgcttacagc cgttacaact tcttggctcg taaacaaagt   1917420
ttggtcttct tcttgatcat ccaaatggtg ccaactatgg ccgctttgac agccttcttc   1917480
gttatggcgc ttatgttgaa cgcccttaac cacaactggt tcctcatctt cctctacgtt   1917540
ggtggtggta tcccgatgaa tgcttggctc atgaaaggct acttcgatac agtgccaatg   1917600
tctttagacg aatctgcaaa actagacggt gcaggacact tccgccgctt ctggcaaatt   1917660
gttctaccac ttgttcgccc aatggttgcc gtacaagctc tctgggcctt catgggacct   1917720
ttcggggact acatcctctc tagtttcttg cttcgtgaga aagaatactt tactgttgcc   1917780
gtaggtctcc aaaccttcgt taacaatgcg aaaaacttga agattgccta cttctcagca   1917840
ggtgctatcc tcatcgccct tccaatctgt attctcttct tcttcctaca aaagaacttt   1917900
gtttcaggac ttacaagtgg tggcgacaag ggataattta tccccgccac cctttttcat   1917960
tttatactct tcgaaaatct cttcaaacca cgtcagcttt atctccaacc tcaaagttgt   1918020
gctttgagca acctgtggct agtttgcact ttgattttca ttgattatta gcaattgtca   1918080
ctgtaaataa tatccttgta gcaagcaatt tttctcctag acttgaaata aagcgcattt   1918140
ctctatataa taatactcat atagaaaaca ccttttagaa agatacctat gcttccatat   1918200
ccattttcct atttttcaag tatttggggg gttcgtaagc ccctgtccaa acgtttcgag   1918260
ctcaactggt ttcaacttct ctttaccagt atcttcctta tcagcttgtc tatggtaccc   1918320
attgctatcc aaaacagctc ccaggagacc tatccgctag aaacttttat cgataatgtc   1918380
tatgaacctc tgacagataa ggttgtccag gatctctctg aacatgctac aattgtcgat   1918440
ggcacattaa cttatactgg aacagctagt caagcccctt ctgttgtgat tggtccaagt   1918500
caaatcaagg aattacctaa ggacttgcaa ctgcatttcg atacaaatga gctagtcatc   1918560
agcaaggaaa gcaaggaact gacccgcatc tcttaccgag ccattcagac tgagagtttc   1918620
aaaagcaaag acagcttgac ccaagcaatt tctaaagact ggtaccaaca aaatcgtgtc   1918680
tatatcagcc tcttcctagt tctcggtgcg agcttcctct ttggtttgaa tttctttatc   1918740
gtctctcttg gagctagctt tctcctttat atcaccaaaa gatcacgcct cttttcattt   1918800
aataccttta aagagtgcta ccattttatc ttgaactgtt taggattgcc gactctgatt   1918860
acacttattt tgggattatt tggccaaaat atgacaaccc tgattactgt acaaaatatt   1918920
ctttttgttc tgtatctggt cactatcttt tataaaacac atttccgtga tccaaattac   1918980
cataaatagg agatttttat gcccgttacg attaaagacg tggccaaggc tgctggtgtt   1919040
tcgccttcaa ccgtaacccg tgttattcaa aataaatcaa ccattagcga cgaaacaaaa   1919100
aaacgtgttc gcaaagctat gaaggaactc aactaccacc caaacctcaa cgctcgtagc   1919160
ttggtaagca gctatactca ggttatcgga ttagttcttc ctgatgactc agacgccttc   1919220
taccagaatc ctttctttcc atcggttcta cgtggcatct ctcaagtcgc atctgaaaac   1919280
cactatgcca ttcagatagc aacagggaaa gatgagaagg agcgtctcaa cgctatttca   1919340
caaatggtct acggcaagcg tgtagatggg ctaatttttc tctatgccca agaagaagac   1919400
cctctcgtaa aactcgtcgc agaagaacag ttccccttcc ttatcttagg taaatctcta   1919460
tctcctttca tcccacttgt cgacaacgac aatgttcaag ctggttttga tgcgactgaa   1919520
tatttcatca aaaaaggctg caaacgcatt gcctttatcg gaggaagtaa aaagctcttc   1919580
gtgaccaaag accgtttaac aggctatgaa caggcgctta aacattacaa acttaccact   1919640
gacaacaatc gcatctactt tgccgacgag tttctggaag aaaagggcta taaatttagc   1919700
aagcgattat tcaagcacga tccacaaatt gatgctatca tcacaaccga tagcctccta   1919760
gctgaaggtg tttgtaacta tattgccaaa caccagctgg atgtccctgt tctcagcttt   1919820
gactcggtta atcccaagct caacttggca gcctatgtcg atatcaatag tttagagctt   1919880
ggtcgtgttt cccttgaaac tattctccag attattaatg ataataaaaa caataaacaa   1919940
atttgttacc gtcaattgat cgcccacaaa attatcgaaa aataagagac tgggcaaaaa   1920000
gtcgttaaaa gcaaaaacgc atactatcag gtattgaaaa aacttgatac tatgcgtttt   1920060
attgtgggaa gatttacttc cttttctact gaaattgagt cttttcccaa gatcttttta   1920120
tactcaatga aaatcaaagt gcaaactagg aagctagccg caggttgctc aaaacactgt   1920180
tttgaggttg tagatgaaac tgacgaagtc agtaaccata cctacggcaa ggtgaagctg   1920240
acgtggtttg aagagatttt cgaagagtat taatcactaa ttatctatct caacaaatct   1920300
tcctagaata tgaacatttt ccgagacaga gacaaaggag cttggatcca cttgtgtcat   1920360
aatctgttta aattcattaa actctgcacg tgtaatgaca gtgattaaaa ctgcctttct   1920420
ctcgtgatta taggttcctt ctgcatcgtg gatcatggtt gctccgcggt gcaatttttt   1920480
atggattttt tcaattacct tctctggatg atttgtcaca atcatggcct gcatacgctt   1920540
ttgcttagta aagactgcgt ctgtcacacg gctagagaca aagatggtaa tcatagaata   1920600
aagagcgtat ttccaaccaa aggtcaaacc tgctatcagc atgatagttc catttaccaa   1920660
gaaagaaata ctaccgacat tcttacccgt tttcttacga atagtcaggc tgacgatatc   1920720
cgtcccacca ctggagatat tgtttcgaag agcaaaacca atccccaaac ccataacaac   1920780
acccccaaaa agggaattga taatgggatc ctctgtcaag gttgccacag ggacaaactg   1920840
gataaagaag gaactcatag ataccgtgat aaaggtaaag acggtgaact tatggccaat   1920900
ctgataccaa gctaagacca tcaaagggaa gttaatggcg tagaagctta gcgaaatcgg   1920960
aatatgaaaa ccaaaccagt gattactcaa ggcagagata atctgtgcca gacctgttgc   1921020
accactcgaa tacacatgcc ctggttggaa aaagaaatta actgctactg ctgataaaaa   1921080
accatagacc agagaggccg aaatcttctc atcatacttt tctcgagaga tactttgtaa   1921140
gacacgtaaa atttttatct gataagcaaa gcggcgcaga taatagcgcc accgcttaat   1921200
tcgttttgtt tgtttcatct tcttctactt gtaagctgag ttcctctagt tgtttgagag   1921260
cgactgttga tggagcttgt gtcattgggt cagttgcctt gttgttctta ggaaaggcaa   1921320
tgacttcacg gatattttct tctccagcaa gcaacatgac aaaacggtca agcccgatag   1921380
ccaaaccacc gtgtggtggg aaaccatagt ccatggcttc aagaaggaaa ccaaactggt   1921440
cattggcttc ttcagttgag aaaccaagag ccttgaacat gcgttcttga aggtcttttt   1921500
ggttgatacg aaggctacca ccaccaagct cataaccgtt caagacgata tcgtaagcaa   1921560
tggcacgaac cttagccaaa tcaccttcta attcatgagc agtctcttcc tgtggaagtg   1921620
tgaaaggatg gtgggcgctc atgtagcggc cttcttcttc agaccattca aacatcggcc   1921680
agtcaaccac ccaaaggaag ttgaacttat cattatcaat caagccaagc tctttagcaa   1921740
tacgtccacg aagggcaccc agtgttgcat tagccacttc aagcgtatcc gccacaaaga   1921800
gaaccaagtc cttatcttca agaacaagcg ctgttgtcaa ttcttcttgg ataccagtca   1921860
agaacttggc aactggtccg tttaattctc catcaaccac cttgacccaa gcaagacctt   1921920
tggcaccata ctgtttggct acttccgtca tcttgtcgat gtctttacgt gaatagttgt   1921980
ccgcagctcc tgtgaccaca atcgctttta cagcaggtgc ttctgaaaag actttaaagt   1922040
ctacacctcg gaccacttct gtcaagtcct gaagcaacat gtcaaaacga gtatctggct   1922100
tgtcagaacc gtaaagagcc atagcatcat cgtatttcat acgagggaat ggtagcgtta   1922160
cttcgatgcc ttttgtttcc ttcatcacgc gcgcgatcaa gctttctgta atatcttgga   1922220
tttcttgctc agtaaggaag gacgtttcca agtcgacctg agtaaattca ggctggcggt   1922280
ctccacgcaa gtcctcgtca cggaaacatt taacgatttg gtagtaacgg tcaaaaccag   1922340
cattcatcaa gagctgtttc gtgatttgtg gactttgagg aagagcgtaa aaatgcccct   1922400
tattaacacg agacggcact aaataatcac gcgccccttc aggcgttgac ttagaaagga   1922460
atggtgtctc cacgtcgata aactccaact catccaagta gttgcggata gagtgggtca   1922520
ccttggcacg aagtttaaga ttttccaaca tttctggacg acgaaggtca aggtaacggt   1922580
aacgcaaacg tgtatcgtca tttgcctcaa tgccatcctt aatctcaaat ggtgttgtct   1922640
tagctgtgtt aagcacaata agagctgtca cgtttaactc aaccgcacca gttggcaact   1922700
tatcattggc ttgctcacgc gcagcgacct gaccagtcac ctcaataaca aattcgctac   1922760
gaaggctttc agctgttgcc ataacctctg cagatacttt ttcagggttg ataaccaact   1922820
gcatgattcc ttcacggtca cgaagatcga taaagatcaa accaccaagg tcacgacgac   1922880
ggccaaccca tcctttcaag gttatttctt gtccgatgtg ttcctcacga acacgaccag   1922940
catacatact acgtttcatt atttctctcc tcttttattc tgttactatt ttaccataaa   1923000
agcgcaggct cttcatgaaa atcatcagaa aagtttgcca gtctttaaaa gtcaggtgaa   1923060
agccctaaaa attagcgcta atactcttcg aaaatctctt caaaccacgt cagcgtcgcc   1923120
ttaccgtatg tatggttact gacttcgtca gtttcatcta caacctcaaa accatgtttt   1923180
gagctgactt cgtcagttct atccacaacc tcaaaacagt gttttgagca acctgcggct   1923240
agcttcctag tttgctcttt gattttcatt gagtataata caaaaatccg atgaacttca   1923300
ccggactctt ttattttgaa tttttgcctg ctttacgctt ttcagcgatt tcggctgcct   1923360
ttcgaggcaa gacaatttcc gttatgtaag ccgtcccaaa acgcagtaca cctgcaatag   1923420
gagcaaagac aactgctaga tagttataga agaaatcgcc tttgaaggca taagctagcg   1923480
ctccaatgat gaaaaataga acgactgcct gaatcactgc taataaaatt actcgtttca   1923540
tgtgacctcc tgactctatt atagcatgag aatcatcaaa aagccgacta aattattcaa   1923600
agcgtgaaga gaaatactgt agaccagacc ttttctgcta atgtaagcca aacccaaact   1923660
aaaaccaagg ctaaaataga caaaaaattg ttgcacatca cctggaaaat gaatcaaggc   1923720
aaatagaaga ctagatacca gaagaaaaat cagggttcgt ttactattgt cctgcttagg   1923780
aaagagatag cgtgctaaca tccctctaaa aacaatctct tccgtcaaag gagcaaaaat   1923840
aaccacagca aagaatgaga aaagtggttg agacaaggtc aagtctgtcg ctatttgctg   1923900
atttactgaa ggatcatctg gcaagaagaa ttgaacgacc agagataaga accaaaccaa   1923960
gacaggaagc caaataaatc gattaaagcc gctcttctca atatgaacag gagccttctg   1924020
ataccatttg taaatgccgt acacatatac tccagccaag gccacataga gtagagtaac   1924080
agcatagggt gaagcgccta aagcaagcga cgcagtcgcg agcccctgaa taaagccata   1924140
gataaataaa aaggatagaa gggctagaag aatccagcca aggtttttaa gtaatttcat   1924200
agataactcc tttatttgaa ataacgtttt accataggta actgcatcac attgatataa   1924260
acatggatgg ctcctacaag caagaaagct agtaactgaa tctctcctgt caagaaagaa   1924320
atgataataa gaaaaatata taaggctggt aagacatatt ggtgtaattg gaataaaatt   1924380
cgaaaactct gttccaaatt agcctgacgc tccccttcat cataagaatt tatatagttc   1924440
aagacatcct ttggtgtagc gaaaaattcc aaatcaaact gacgaacaat cgcaatggtt   1924500
ttaaaaagag atttttgagc gactaagaat accacaaaga gtaagaaaga aaggaaaaat   1924560
gtttgagggt ttgtatgcaa tataatcacc tcacttaatg aaataaaaat agccaatgga   1924620
atcgctacac ctgtaatatt aaaagcaatg gttccaaact caagattccg atacatttgc   1924680
acataatagg tttcattcag atcgtcatcc atttcctctt gatacaaaga atgaaatttt   1924740
ctgcttttct ttaagaaatt gaaagtcaaa aacatactaa tgaaacctat cagtaaacaa   1924800
atagctgata tccatggcat caaggctttt acatctaaaa taatttcgtg ggattcgaca   1924860
cgtgccttaa acatccctac aaacatgccc aagaaccccc caagacaata gacatcaaaa   1924920
ataacaatct acgtttcttt ttcatattca ttctcctttt tcacttgcta gatttttgga   1924980
tttcttttca atccattcaa ttactgggat gagagcaaag tagacccaaa caaattggtc   1925040
gctttgatag ggattaaacc agcttaggtc catcccaatc agtagaaata cgctgactaa   1925100
taaagctatg accactacat aataaatcac tttatacttg ttcatcactc gtcctcctcc   1925160
aaacgaaata ccgattcgac tgtttcgttg aaaatttgag atattttcag ggcaatgata   1925220
atggatgggg tgtactcatc ccgttctagt aggctaatgg tctgtctgga aacccctgcc   1925280
agtttggcta ggtcggtttg attgagacca tcgcgagctc gaagctcttt tagacgattt   1925340
tttagttgca tgttacacac ctactctccg tcaaattcaa cggtttggat atcctcaata   1925400
cgttgcaact tgaatttttc ttttcccgta ttatctacac gtcgtagctt tacccattcc   1925460
tcatcaacat ccacaacttc ccagttatct ggcccaatat acactcccgt tataattggt   1925520
tcctttccaa tcatttcttg taataatctc gacatttctg cgtttccttt ctcttttcgc   1925580
tcaagtcttt tgattttatt ctctagtttc ttgatttttt tagaattatt agaataaaag   1925640
aaaatcataa atagtataaa tcctagtacc cacattataa ctcctttctg cttcctattt   1925700
cttaacttga attcattgta acatatcttt ttctttttga caagtatagt tgtcaaaaaa   1925760
attatgattt ttgtcatttt gcaaaagaaa aaggtcagga gtaggttcct gaccacttta   1925820
tctatcatta atactcttct aaaatctctt caaaccacgt cagcttcacc ttgccgtagg   1925880
tatggttact gacttcgtca gtttcatcta caacctcaaa accatgtttt gagctgactt   1925940
cgtcagttct atccacaacc tcaaaaccat gttttgagct gacttcgtca gttctatcca   1926000
caacctcaaa accatgtttt gagctgactt cgtcagttct atccacaacc tcaaaacagt   1926060
gttttgagca acctgcggct agcttcctag tttgctcttt gatttttatt gagtataaaa   1926120
tcctagtttt tcaaagattt ctgagaagtt ttggctgatt gtctcaagtg acacttgcac   1926180
ttcttctcgg gtttggttgt tcttgaccgt cacttgtccg ctttcgactt cgctctctcc   1926240
tagggtgatg agggtcttag ccgcaaagac atcggctgac ttgaactgag cttttagttt   1926300
acggttgagg taatcacgct ctgctttgaa accttgttgg cgaagagcct gtaccaattc   1926360
caaggccttg atatttgccc cttcgcccaa gactgcgata tagacatcta gggcgttttc   1926420
gatagggagg gtcacacctt gcttttcaag gatgagaagc aggcgctcta caccaagtcc   1926480
aaaaccaaat ccagcagttt cagggcctcc aaagtaagca accaaaccat cgtagcgacc   1926540
acccgcacag acggtcaggt cattgccctc aatctctgtg ataaactcga aaatggtgtg   1926600
gttgtagtag tccagaccac gcaccatatt ggtatcgatg atgtaatcta ctccaagatt   1926660
ttccaacatc tgacgcacag catcaaaatg agcttggctt tcttcatcaa gaaagtccaa   1926720
gatagacggc gcattctcta ctgccacctt gtcttctttt tccttagagt ccaagacacg   1926780
aagaggattt tcctccaagc gacgttggct atccttagac aaggtctcct tgagcggtgt   1926840
caaatagtca atcaaggctt ggcggtaggc tgcacggctc tcaggatttc caagagtgtt   1926900
gaggtgcaat ttgacacctt gaataccgat ttccttcaaa aaatgggctg ccatagcgat   1926960
tgtttccaca tcggtagctg gattgctaga gccaaaacac tcaacaccaa tctggtggaa   1927020
ttggcgcaag cgccctgcct gtggacgctc ataacggaac ataggtccca tgtagtagaa   1927080
cttgcttggc ttttgcactt ctggggcgaa aagtttattt tccacatagg aacggacaac   1927140
gggtgcagtt ccttctggac ggagggtaat atgacggtca cccttgtcat aaaaatcgta   1927200
catttccttg gttacgatat ccgttgtatc tccgacagag cgactgataa cctcgtaatg   1927260
ctcaaaaata ggcgtgcgca cttctgcata gttgtagcgt ttgaaaatct cacgggcaaa   1927320
gccctcaacg tactgccact tagcagactc agcaggtaaa atatcctgcg ttccttttgg   1927380
tttttgtaat ttcataggga atcctcttta aacttaatag tcttatttta ccataaatag   1927440
agggattaaa acagtaagaa aaaaattagg atttagatat catttttgag attaagaatt   1927500
gtcaaaaaaa tagctagcaa ggaaagacca acaaatagca tccaagtcaa ctgtatattc   1927560
catacggcta ctagtgaaaa acaagctgtt cccacaggta tggataaggt aaacaataga   1927620
cctaaaaaat tactagtacg agctagaacc tctggagcta gatttttcat gagcatggca   1927680
ctaatctttg gttgaacttt accagacaca tacagagtaa agaagagaaa tagcaaacca   1927740
agcacgactt gattgaataa attagccaaa ccaactagac taagtcctac ggtctcccac   1927800
atcatcaatc taggcaagga ctgcttccca aaataatcat tgcccgtaag gctactgatg   1927860
atgactgata ctaaaacaca gaattgattg ataaatagtg cctctgtata agaaaaattc   1927920
aagagagaat ggctcaaaaa gaagatatta taaattccac ccaaagcgcc acccaaggaa   1927980
ttaataagca agacagcaaa gagcataaaa ccaaagtttt tctgtccact tttaagaaaa   1928040
acgagacgta aatttcggta aattgttagg aactggtctt tgatagaaag cttctcattt   1928100
tttaagtttt caccatcagc agatgacatt gacaggctca atttgctttt tcctaaaaag   1928160
aggatagtgg ctgatactag gaaaaagcag gcattgattc ccgcaacgag agaaaaattg   1928220
ttgaccgata gagctaagag ccagactccg aaagcttgac caccaatagc tgaaatatag   1928280
gtgatgaact gtgaaaaaga ataagcctcc atcagatcat cttcagctac tttttcctta   1928340
ataagaggca tacgcaggcc acctgcaaaa tcactgatga tatcactaat gacattgatc   1928400
aaacacaggc tagaaaaggc aaagagacta gcttgctgaa caactagggc tgctagaaaa   1928460
aatagaaccg cctgaaacaa accgctatag accatccatt tgaccttgtc cctcgtgtaa   1928520
tctgcccgaa tccctgcaaa aactgtaaag agggtcggaa gaatcatgac aatattcgcc   1928580
atagcaacag caaaagatgc ttgtgacaag gtcgatgcat agacgataaa gaccaggttg   1928640
aaaatcgaaa caccaaaagc attgaagaag cgtgataaag tcaaaattct ataagctgga   1928700
tttctaaaca atagtttcat agataatctc cctccttgtt ctaagttcta catcaagaat   1928760
agctttagta tagcacttat gaatttgcga aacgattctt ttgaatatat gcaacaaaca   1928820
aaatgagcaa aaaaacgata gaacttttgt aatgacctga gagagggcaa cagttctatc   1928880
gcttcaaatt ttttcttggt ttgcagatat tcaagaatcg ggagtttttc tatagtattc   1928940
ggcagattta ttacagccaa gcatctcaaa aatacggaca gcatcctcca tctttttctg   1929000
gccttccttg actctacctt gcttgctatc aaggagacct tctgcccaca gataaacaat   1929060
tcggaaatag gtctcatttt ccttgtagaa atgctcttcg ataacacgtt taaaataata   1929120
ggcattggta aattcttcac actcaatact agctaaaaag ccattcaata gtatagtatg   1929180
aaaaaggttt cgattgccag acatttccat tagaaaatca gatttacgta ccatttctcg   1929240
tacatatcta gtaaaaagag aaacagataa aaatggagaa ctgactgaaa ataaattgag   1929300
ttcatagatt ccccagatct cggtagaaaa caaataatca tgaaggactt ttccttcctc   1929360
tgctgttaag tctacccttt catctatgct cttcatataa gacttgataa taatggcatt   1929420
tagaatatgt ttctgtttgt tgtgagaatg ggcatgcttt tatactccct gcgatataag   1929480
tcctcaagag gtgctatatt ctttggttcc aagacatctg taatttcttt tctcaactca   1929540
gaatctgtat catactggaa acctcttgcc agaaagagga tctcctccac actggcagat   1929600
atattttcca gagcaaatag aaacttttcc accgaaagct cactctgacc tgtttcaaaa   1929660
cgggacaaca tagacggcga aaattgtcct ccggttgctt gtctcagtga gatatttctt   1929720
gactctcgta attgtctaaa gacttttcca atctgctcca tagacttccc cttgattccg   1929780
tattttcttc attttatcat atttttcaga aaattcatca aaaacttgcc aaattgtcag   1929840
aattatgaga aaatagagga tatttatcac gtggagggac tgctatgaga gacgatatca   1929900
aaatcaatga ccgtgctttg gccttgcaag accaaattat cgaaaaacta gagaaagttt   1929960
ttgatacaga tgtggaattg gatgtttaca atctaggtct gatttatgaa atcaatctgg   1930020
atgaaacggg gctctgcaag attgtcatga ccttcaccga tactgcctgt gattgcgccg   1930080
aaagcctgcc tattgaaatc gtggcaggtc tgaaacaaat cgagggtatc aaagatatca   1930140
aggttgaagt tacctggtcg cctgcttgga aaatcacacg aatcagtcgc tatggccgta   1930200
ttgcccttgg actaccacct cgttaagcag accaatcact tttaaagatg aaaatcaaag   1930260
ggcaaactag aaaactagcc gcaggttgct caaaacactg ttttgaagtt atggatagaa   1930320
ctgacgaagt cagctcaaaa cactgttttg aggttgtgga tagaactgac gaagtcagct   1930380
caaaacactg ttttgaggtt gtggatagaa ctgacgaagt cagcccaaaa cactgttttg   1930440
aggttgtgga tagaactgac gaagtcagta accataccta cggcaaggcg acgttgacgt   1930500
gatttgaaga gattttcgag tatgagttta ttttttacct gacttgtcca tattccagaa   1930560
gtctgtcacg gctccgcgtg aagcagatga tacgatgtgg gcatatttac cgaggacacc   1930620
acggctgtaa agtggtggca aggttgtttc tgccttgcgt ttttcaagtt cttcttcgga   1930680
tacggccata gaaatttctt tggtatcttg gtcaaccgta acgatatcgc cggtacggag   1930740
ataggcaatt ggtccaccat cctgagcttc aggagcgata tgtccaacaa ccagaccata   1930800
agtaccacca gagaaacgtc cgtccgtcaa gagggccacc ttatctccct gacctttacc   1930860
aacaatcatt gaagaaagtg atagcatctc aggcatacca ggaccacctt taggtccaac   1930920
aaaacgaaca acgactacat cgccatcaac gatttcatct gtcagaacgg cctgaatcgc   1930980
atcttcttct gagtcaaaga ccttagctgg cccaacgtga cgacgcactt taacacctga   1931040
taccttggca actgcaccgt caggagcaag gttcccgttc aagatgataa gcggaccatc   1931100
cgcacgtttt ggattttcaa gtggcatgat aactttttgg cctggagtca agtctgcaaa   1931160
gtcagccaag ttttcagcta cagtcttacc agtacatgtg atgcgatctc cgtgaaggaa   1931220
accatttgcc aacaaatact tcataaccgc agggacacca ccgacttcgt agaggtcttg   1931280
gaagacatac tgaccagatg gtttcaagtc ggccaagtga ggcacacgtt cttgaatcgt   1931340
attgaagtcc tcaagtgaca agtcaacatt tgcggcatgg gcaatggcga gcaagtgaag   1931400
agtggcgttt gtagaaccac cgagagccat cgttacagtg atagcatctt caaaggcttc   1931460
acgagtcaag atatctgatg gtttgagacc aagttccaac atcttaacaa cagcacgtcc   1931520
tgctgcttcg atatcttctt tcttatcagc tgattcagct gggtgagagg atgaccctgg   1931580
caaactcatc cctagaactt cgatagcagt tgccatggta ttagcagtat acataccacc   1931640
acaaccacca gggccagggc aggcattaca ttcaagacgt ttcacgtcct cagctgtcat   1931700
gtcaccgtgg ttccattttc cgataccttc aaagacagaa accaagtcga tatctttacc   1931760
atcaagattt cccggtgcaa tagttccacc ataggcgaaa atagctggga tatccatatt   1931820
agcaatagca atcatagatc caggcatgtt cttgtcacag ccaccgatag cgacgaaggc   1931880
atccacgttg tgaccactca tagccgcctc gatggagtcc gcgatgatgt cacgagatgt   1931940
tagagagaaa cgcataccag gcgttcccat agcgatcccg tccgctacgg taatggttcc   1932000
aaactgtaca ggccaagcgc ctgcagattt gacaccttct ttagccagtt tcccgaaatc   1932060
atgcaagtga atgttacatg gtgtattttc cgcccaagtc gaaatcactc ccacaatcga   1932120
tgtttcaaag tccttatctg tcataccagt cgcacgaagc atagcacggt taggtgattt   1932180
aaccatgctg tcataaatgc tactgcggtg acgtttatct aattcagtca tcttatccct   1932240
cccatttcag tttttactat tatagcacaa ttttcgcatg aagaacagaa taaaattctt   1932300
gaattttcag aaaattctat acacatgtga aatatttaaa attaaaaaca acaaagcgga   1932360
ttagtgcact ttctgatgac cagaatatgc tttttaatcc gctttcttta aataacgtac   1932420
tgtaattttt acagaaattc tttcaaataa gtgtatttaa catctatctt gcattataaa   1932480
tttctagaac cttctctttt atattcgatt cactcaaacc atactcatta agaagataat   1932540
ccattttccc tacttgaccg aatctttctt gaacacccat ccgatgaatt tttgttattc   1932600
catcatcaga gaataattca cataaagcac tgccaattcc acctatctga ttgtggtttt   1932660
ctacagtaaa tatagttttt ccacttaaca ttgtttttat ctgttctggt atcggtttga   1932720
ttctaaataa atctatcaca cctactgaat aacctaattt agacagttca tctgcaactc   1932780
gaatacttgg agcaaccatt atgccagaag caacgattac aagatcttca ccatgcctta   1932840
actcaatgta gcctttagaa aaatcttctc caccttgata cacaggaact ggagcttttc   1932900
taattgttcg aatatatttt agtcctttta agtctaatgt ctggttcaat atttcacgaa   1932960
attggatatc atcagttgct tcgaaaatga ttgatttagg aattaaacgt aacaatccaa   1933020
tttcttcaaa tggcatatgt gttccaccat tcatctctgc cgttactcct gcatctgatc   1933080
caatcacagt ggcatccaat tgtgcgtatc caagagaaat aaataattga tcaaatactc   1933140
ttcgtgaagc aaaaggacca aatgtatgaa gataaggtct aaacccctga atagacaagc   1933200
ctgctgcaag gccgaccatt tctgcttcca taatcccaac attcacataa cggtctccaa   1933260
agtccttttc aagattatta gtagccatcg aacttgacaa atcggcttct aagactacta   1933320
tatcagaatc actttgatta gcctctaaaa ggaagtctct atatacatgc cgtaattctt   1933380
tcgtacttct catcattctg tttcctccaa ttcctgactt aatctttcta caactgaagt   1933440
taacatttgt ttctcctcta cagtagggcg aagatgatga ttggatttca tttcttccag   1933500
ctcttgaacc ccttgacctt taatagtatc taatacaatg cacttaggtg atgaattatt   1933560
tgactgtttt aattggacaa tcccttcata aatttctcta atatctgaac ccttgaccct   1933620
aatggattca aatccaaatg ctgaaaattt ttctacgaaa tcacctggat tacaaatatc   1933680
ctttgtaaaa ccatctaatt gttttttgtt atcatcaaca aatacaatta agttggataa   1933740
ctgttgatga gaagcaaact gtatagcctc ccaacattgt ccctcattta actcaccatc   1933800
tccaacaata gcgtaagtat aaaagggact ctttcttatt ctctgaccat atgcaagtcc   1933860
agttgcaaca ctaattcctt gtcctaaaga gcccgttgtc atatctatgc ctggcgttag   1933920
atttctatca ggatgagacg gtaatttggt tccatttgta tttaaagaat ataagaattc   1933980
tttgtcaaag aaaccattca aatagagtgt actgtataga gctggtcctc cgtgaccttt   1934040
tgataatatg aaataatctc tatctcgtgc tgcaaatatt tctggagtca ttggcattat   1934100
ttcaccataa agcaccgcta aaacttctac gatagacaga cttcctccgt aatgtccgaa   1934160
tccaagatga ttcaatgttc taagagtatt taatcggatg ttagtcgcaa attttcttaa   1934220
cccatcttct ctatttttac ttaaaatcat cccttattcc tccgttgcag atggcttttt   1934280
aataaaggat actccaaaca taactgctag aataagaaca agaccaatca caatgcctgc   1934340
ttgtgagcca aattgattta acattcctaa aataattcct gatagaccaa aatctgcatc   1934400
tgagaaagtt gatccttgga aaccaagtcc tcccaaaact ggcattaaaa agactggaag   1934460
aaaactgatt aaaatacctt gtaaaaatgc tccaatagtg gctccacgaa caccaccaga   1934520
tgcattccca atgacacctg cagtcgctcc acagaagaaa tgaggcacaa cacctggtaa   1934580
gataacaacc gttcctgaag caatcataat taccatactt actaaaccac caacaaaact   1934640
agagataaat ccaattagaa ctgcattggg tgcataagta taaacaatcg gacaatccaa   1934700
agcaggtttt gaattaggta caagacgctc tgaaatacct ttaaaggctg gaacaatttc   1934760
gcccaaaata aggcgaacac ctgctaaaat aacaaatacc cctgctgcaa attgacctgc   1934820
taattgtaaa gcataaacta gaccacttgt accactactg atttcttttt ctatatattc   1934880
tgaccctgca aagatagcta caataatgta aataactgcc atggataaag taatactaac   1934940
agtactatca cgtaaaaaag ctaaactctt tggaaattta atgtcctctg ttgattttga   1935000
tttgtcaccg ataaggctac cagtaaaacc actcaaccaa tatcccaaag aactgaaatg   1935060
acctaaagct accttgtcat ttccagttaa ttgaaccata tatttttgca caaatgctgg   1935120
ggaaatactc ataataatac cgagtgctaa tcctcctagt aagatgagag gcaagctagt   1935180
aaagccagca actgataaaa tgaccgcaat catacatgcc atatatagag tgtggtgccc   1935240
tgttaaaaaa atatatttaa atcgagtaaa acgagcgatt aagatattga acaccatgcc   1935300
tgcaaacata atcattgcag tagctgagcc atatgttgtt aaagctacag ctacaattgc   1935360
ttcattattc ggcacaacgc cagataaatg aaaagcatgc tcaaacatgg taccaaatgg   1935420
atttaaagaa ttttgtacaa ttcctgcacc accagataca actaagaaac caacaaaggt   1935480
cttaattcca cctttaataa tatcaggtaa tttcttcttc tgaagaacta atcctaagat   1935540
tgcaattaaa gctactaaaa tagctggtgt actaacaata tccaatatga acttcatcat   1935600
gacgctagcc tcctatataa gtcctttttc ttcacaaagt ttagtaatta attctcgtag   1935660
ttcatccata tcaataatac tatttaagat acgaacatct ccaagatgac tagctgaatc   1935720
agctagatca cgaccaacaa tccaaatatc agctgcattt ggatctgctc cacctaaatc   1935780
ataatgttca acttctacat ccgaaacatt caaatcactc aatacagatt caatattcat   1935840
ctgtaccata aaacttgaac ctaatcctga accacaagct gtaccaattt ttaacattat   1935900
ctaatcctcc tgtttaatta tcattttaat gtcatcatag ttttttgatg atattaaagt   1935960
ttgaacatga tttttatctc ttaaaattgt tgttaaatgt gacaaagcct ttaaatgact   1936020
ctcattatca atggctgcaa tacaaatcaa caatcttacc tcttgttctg gattatccaa   1936080
taaataaatc ggttcttcca aaactaacat tgacattcct atttcattca caccttcatc   1936140
tggccgagcg tgaggaattg ctactccctt ccctaaatta ataaaaggtc caaactcttc   1936200
tactttttga atcattgcct cagggtagtt ctcagttatc ttatcttgat ccaaaagcgg   1936260
tttagctgct aaacgaatcg cctccttcca tcctaatttt tgcgaactaa cctgataggt   1936320
ttctttggta ataagttgtt ctagcactgg tacaatttcc tttctatcat ttttttggta   1936380
aagataattc tttaacgcca atcttaattc caattcttgt gtaataattc catatctttt   1936440
gacaatattc aggatttgtt caatctcaaa atctccatac tctaaattcg gaaaatcttt   1936500
taacactagt tctactagtt gtattgcttg ctcttcagtc atcataaccg aaactagata   1936560
atttggcttt tctgtctcca cctttatggt agaaaaaacc atatcatagt cactactagc   1936620
tttcacctgt aaatcatcaa tctttgaggt tcctataaac tcaatttgag gaaataatgc   1936680
taatagattc tcttttaaca tcaatgaaga actaacacca ttaggacaaa tgattgctgc   1936740
tttataccat ttttgaggca aagtatctgc tttctttaaa taacctccga aatggataac   1936800
aaaatatgct gtttcactat caggtatggg attgtcaata gcgtccatca agggcatcaa   1936860
agaatctttg actaattcaa ataaatcagg ataatgttct ttaacatgca atacatattc   1936920
atttgaacta ggtaggccga actttaatct atagtaagcc ggtataaggt ggcggcgaag   1936980
attttctctc aatccttccc tttgtttaaa atgtaacaaa gaaatatctt ccattctact   1937040
tataatagcc tctgttaatt gattaaagta aaccggagca acatctactt caccttcaaa   1937100
gcaacttgat aataaaacgg tgatatagcg ataatcatcc tcagaaaaca ccgtatctat   1937160
aattcccaaa tcaaccactg tatccaataa aatagtggtt atatcttgaa taacaggaga   1937220
tactaatgtc tctgaaagac atactctttc aacatccctt tgatacctac acagaatgaa   1937280
tactaaaccg aaaaggtaaa cttttaattg attaacaata ggtactagct gtagcttctc   1937340
ataataatct ttaactacct gatcaatcaa atcataagtt aatgaatacc cccaactgga   1937400
taaaacataa tccaaacccc aaatccctat ggaggattcc agcaactcac taaccatttg   1937460
aaaagctaag cggtgcttat tccactctga accgtgtaaa gtataacctt ttgctctact   1937520
gtaccctagc tccaaatcat tatctaacat aatctttctt aatgattgaa tatcagataa   1937580
ggttgtattc ttacttactt tcaaaaagtc ttggtaatga ctattcgata taaaatctaa   1937640
tcggcaaaaa gtgtaaagat agattaaagc taagcgagtc gactttggta aaaccaattc   1937700
atccgactta ataatatctg tcaaagactg cttcgtacga tttgataaac tatagcgacc   1937760
ttgcttttta tccagcacta tccctttatt agctagataa ggcactaaat aatctattcc   1937820
ttctttgact tcctttatag gtaagctcac cttaacagat aattcatata atgatagctc   1937880
acaatgatcc atcaaagtca tcaaaataac tagtgctcta taatcaaaca tttctcttcc   1937940
tttctaacta caattatagt gtaaaaatta taagaataaa agagtatttg agcacaatat   1938000
aatctcacct tttaaaagaa attattgggc tgaaagtttt tagtgattat ttttcaactt   1938060
tctattgact ttataaatta aagtgatatc atttagatat caaataacag gaggtcattc   1938120
ttatgactga aaaactaatc aattcaaaac caaatggtgt attcgcattg attctcattg   1938180
agttgacaat cgtacttggt atctttatat ttataatggg ggttggttcg gaaaacattt   1938240
ttggaattat tatcggacct ttactaatcg taattgcagg tctagctcat gctggtttaa   1938300
aagttgtcaa acctcaagaa gctctggttc tgacactctt tggtaactat acaggtacca   1938360
tcaaagaacc tggcttttac tttgtcaatc ccttcagcgt agcagtcaac cctgcaaacc   1938420
acactcgact tggacaaagt ggtgatgtta gcacaaaatc tcctttttta ggagctaaat   1938480
catcaaatga caatgatgta aatcttgaaa ttggcaagaa acagatttcc ctcaaagtca   1938540
tgaccttgag caattctcgt caaaaaatca atgattgctt aggaaaccct gtagaaatcg   1938600
gtatcgcggt aacttggaga gttgtcgata ccgctaaggc agtcttcaac gttgataact   1938660
acaaagaata tctttcattg caatgtgata gcgccctccg taatattgtc cgcatctatc   1938720
cttacgatgt gtctcctaat gtggatacta cgggtgatgg gcaagcagat gaaggtagtc   1938780
tccgtggctc tagcgaaatt gttgctaacc gtattcgtga agaaatccaa agtcgtgttg   1938840
aggatgctgg cttggaaatc cttgaagcac gtatcactta cctagcttat gctccagaaa   1938900
ttgctgccgt tatgcttcaa cgccaacaag catctgccat tattgatgca cggaagatga   1938960
ttgtagatgg tgctgtagga atggttgaaa tggcactaga acggctcaat gaaggggaat   1939020
tggtagaact tgacgaagaa cgaaaagctg ccatggtttc aaatctcctt gtcgttcttt   1939080
gtggcaatca tgatgcacaa ccaattgtca acacaggaag cctttactaa agatggctga   1939140
agctaaaaaa aagcagatcc cccttcgact ctcaacaaag ttatacgctg cactcgcatc   1939200
atgggcagaa gacgactttc gttcagtcaa tgggcaaatc gaatatctcc tcacagagtg   1939260
tgtcaagcaa cggaagaaag acggaaaata cgtatcagaa accattgacg aaccatttga   1939320
gattgatatt taacaccttc tcctgtctgc cgtgtcggat aggagaattt tttcatcttt   1939380
ttttgtcaag taactttact ttacaaaaaa aatgtgttat cctagtatgg ttgatgaaaa   1939440
tcagtagatt gaatcgaata taaataccta aaggagaaat caaaatggca gtacctgcac   1939500
gtcgcacttc aaaagcgaag aaaaacaaac gtcgtacaca ctacaaagta acagctccat   1939560
ctgtaaactt tgacgaaact actggagatt actcacgttc tcaccgtgta tcacttaaag   1939620
gatactacaa aggacgtaaa atcactaaag ctgcatcagc tgaataatag aagggagata   1939680
ccatgcgcgt aaatattaca cttgaacaca aagaatctgg tgaacgcttg taccttactt   1939740
ctaaaaacaa acgtaacact ccagaccgcc ttcaattgaa gaaatactca ccaaaacttc   1939800
gcaaacacgt tgtgtttaca gaggttaaat aagcattcaa tacgaatcaa tacagaagaa   1939860
aaacgcttga tcagcgtttt ttctttttgt taatttcact acattgtaag ggaaatcatt   1939920
cgaatgacta catttttcac tacctttttt gaaataagaa tacggattcg gacaattaaa   1939980
agcaagagga actcaaatgt aagttggggt tccttttttg tatatttttc aaataacgcc   1940040
tctacactat ttgtagcaaa ttcaccaact acagttgtat cttagttaaa ataagttaga   1940100
atatgtaagt gagtaccaga tataccaaga catcgtcacc atctaaggta tattcaaaat   1940160
acaaaagttg accaactaga tttctgaata tccttatata tccattctta aaattggttt   1940220
aaatagcgta gtcttttaaa ctagttttga gaatccaaaa aatcttccta catatgtaag   1940280
aagatttttt agttcagaat gattagattt agctaatgga tacctatcct acccactcac   1940340
cgttagcatt gactcgatag ccatcgggtg tagtcgtgtt tactaataaa tctcctgaat   1940400
tataggtata gtaccattta ccagaaactg taacccaacc agtagccatt gaacctgatt   1940460
catttaagta ataccataag cctttgtctt taacccaacc agtagccatt gaacctgatt   1940520
catttaagta gtaccataag cctttgtctt taacccaacc agtagccatt gaacctgatt   1940580
cgtttaagta ataccataag cctttgtctt taacccaacc agtagccatt gaacctgatt   1940640
catttaagta gtaccataag cctttgtctt taacccaacc agtagccatt gaacctgatt   1940700
cgtttaagta ataccataaa cctttgtctt taacccaacc agtagccatt gaacctgatt   1940760
cgtttaagta ataccataaa cctttgtctt taacccaacc aactactccc tgattagaat   1940820
tctttttagg tttagctaca tcagtttctt gttttatatt atctactttt tcaacaatga   1940880
tatcattact agtagataaa tttgatttaa gaacatcttt tatatgttct gatgttacat   1940940
agaacttaac agtttcagga attgcaaatg tatctttttt cacagaaaac tctgtacttt   1941000
tattcttaat atgaatttcc tttaatgaat ctaagacgcc acttaggaag aaggacggca   1941060
atgagttgat attattacca attgttaaac tttttaattt tggtaaaccg ttcataacgt   1941120
gtttaccaaa atttttaaca ttatctggta atataagttc ttttaattct aaattaccgt   1941180
aaaaggctaa acgttcaata gtttctaaac tatttggtaa gctaatttct tcaagtttaa   1941240
tcgcatctgc aaatgcaaaa gtaccgattt tttctaaacc ttcattcaat tcgagttttt   1941300
tcaagtaaga atttttatta aacgaatatg atgcaagttc ttttgtctcc ttaggcgttt   1941360
tataactttc gtcatttttt tgacttggat aataaattaa ttgggtttta tcttttgaaa   1941420
acaaaacacc atcaactgag gcaaacgatt catttccttc ttcaacatca acatgtttta   1941480
agctagtagt gagtctaaat agattacttc ctaatgtttt aaccgatttt ggtaatgtta   1941540
gtttctctaa atttgataaa ttagcaaaag cctcatgtga tattaattct aattttgaac   1941600
ttgaggaaaa ggttagcttt ttcaattttt gactaaaaga aaatgcactt gttccaatat   1941660
attctagaga tgcaggcaat tcaatctctt ctaattcaga aaaatcaaaa gctctatctt   1941720
caattttctc cagctgactg cctttgtcaa aaataatagt tttagcttta cttccatgga   1941780
agcctttttt ttgtattttt tttatgcttg atgggatagt aatagagcta ggatagtaga   1941840
caattctacc tgtttcatct ggataataac taaaagcttg actagctact tcagtaacgg   1941900
taaatacttt atcacctact gtgatttttg taggaatcgt gaatggtttt ccatcttgac   1941960
cagcttcaaa ctctacagga gtaactccat tacccacttg aacagttcct atgttacctt   1942020
ctacagttag aaccttatat ttgatattat tttgttgaat aatacttcca actttagtct   1942080
ctttgattac ttccgaacta ggagtatctg ctaggattgg ttcattaggg acatatgctg   1942140
ctaaaataac cgcagctgta gttaatgata atattgtagt ttttttcatt taaatttcct   1942200
tacatattta ttttctaata gatataaaat tataactttg ctagccgttg ttataaaaag   1942260
ttttattcaa tcattatcta gtagaataga gtagtacatt ttataaattg tcatctctcc   1942320
ataaacacag tatatcattt ttaaatttta agtcaagaaa aattaaccca ctttaatttc   1942380
ttttttaacc cgtgttaaaa aagaaattaa agtgggttaa aaaagaaatt aactgagtaa   1942440
aaactctcga aattcaattc gctatattat cactcaactt gaacaaatac cagaaccaca   1942500
aaaaacagat gtaaaggaaa aatatggact taaaatttga aggggttgat ttagaataca   1942560
aaaaagctaa aaacaatctt ccagagtctt tctgggaaac ctactcagca tttgcaaata   1942620
caaatggcgg gaaaataatt ctcgggatag atgaaaaaaa cattgacacc taccaaagag   1942680
tcaatagact ccctgcgaaa ttatgaagca agtaaacaat taactgatac acgatttaag   1942740
cgtcttgttg gtgttcagcg cacgactttt aaagagatgt tagctgtatt aaaaacagct   1942800
tatcaactta aacacgcaaa aggtggacga aaacctaaat taagcctaga ataccgcact   1942860
tatgaagaaa ttgcggctga ttttggtatt cacgaaagca acttaatccg tcggagccaa   1942920
tgggttgaag taactcttgt tcaaagtggt gttacgattt caagaactcc tcttagttct   1942980
gaggacacgg taatgattga tgcgacggaa gtaaaaatca atcgccctaa aaaaagaatt   1943040
agcgaatgat tctggtaaaa agaaatttca cgctatgaag gctcaagcga ttgtcacaag   1943100
tcaagggaga attgtttctt tggatatcac tgtgaactat tgtcatgata tgaagttgtt   1943160
caaaatgagt tgcagaaata tcggacaagc tggtaaaatc ttggctgaca gtggttatca   1943220
agggctcatg aagatatgtc ctcaagcaca aacttcacgt aaatccagca aactcaagcc   1943280
actaacagct gaagataaag cctataacca tgcgctatct aaggagagaa gcaaggttga   1943340
gaacatcttt gccaaagtaa aaacgtttaa aatgttttca acaacctatc gaaatcatcg   1943400
taaacgcttc ggattacgaa tgaatttgat tgctggtatt atcaatcatg aactaggatt   1943460
ctagttttgc aggaagtcta ttgaaatact aagcctacac agactgattt caattttacc   1943520
attcttcata gtcaaaacca tcataatctg gatattgttc tggcgacgtt ccaaccgaac   1943580
gtacgagata agcttcttcg tcctctgtct cgatttctct cagcacttgg cattcaaaac   1943640
gccattcatc accgaagtcg aaaataaact taaatttttg tttgacactt aggctatcca   1943700
gatagacatt ttctgtgtaa cgttcttcaa catcgtcact aacaaagcta cgaaagtaag   1943760
aatctgcatg actccactca acattatcca tgaaaaatgc gtgagcatga tcatttgcaa   1943820
aatcaaaact ccataaaatc acatctgcta gttccgctaa cgtttttgtt tttggaatct   1943880
atatatgtcg gtagcaacct tttttaaatt tgacggaaat gatccaagct tctacagatg   1943940
ctggcttttc agcttctatt tcttgtttta ctaattttaa gtgtagcata atacctccaa   1944000
ttgctcttag gaaacattca ctttctgcta ttttatcata agtttgtcta actgtagcat   1944060
ttgaaaccag ataattcttc tgtttcacgc gaaacaccct gcgccaagca aggtgttctt   1944120
gtttttatac tcaatgaaaa tcaaagagca aactaggaag ctagctgcag gttgctcaaa   1944180
acactgtttt gaggttgcag atggaagctg acgtggtttg aagagatttt cgaagaatat   1944240
taagtcgtat aaatcgtcga cgctgtcgca atggtatgcc actggttggc tgtagttgct   1944300
gcgaaatcct tgtctgcgta gaagtcagta aatggtagga tttcaacttc cagctcgtcg   1944360
atgcggtcaa gctgaccagc cagataaacc tcgatacggc tttctgctcg tttgatgcgt   1944420
tgcaagagtc cgcccatacg gatgtcaact gtatccaaac caaagacctt gttttctttc   1944480
agccattggt ggctaaagag ggcatggaag tcttcaattt ggcttctaag ttctggtaat   1944540
tcttgtctgg cgatttgttg taaactttct ttatcatccg cttggtaggc ctgacgaatg   1944600
cgtcgtccca catctacttt gctacttaaa atagcattca actgggcctg agtttcaaag   1944660
agataggcat agtttccagc tttttcttta atgttagcaa gcgtctcagc agcctgagcg   1944720
aagtgcggtt tgtcctgttc aggtgtcatg tgttgatcaa gaatcggaca aagaatatcc   1944780
tgataaaaaa catagcggtt gggattgata ccgctgagat tgcctggtag gtctggtaag   1944840
aggttggcaa ggtcaatctg cataaaatcc tcaaccgtta gaccagtatt ggtcttgaag   1944900
tgcgcagaca aaccatctag gtcattgcga tagctgagtt ctgcccagat ttgcaagctt   1944960
ggtaggatag agaactgggc agtttcacca ccattgtctc cccaacccgt tacgatgact   1945020
tctttaatct gattggcacg gcaggcttta ttagcctcga tagccactag acggctaaaa   1945080
tggttgtgag gtgtaaagcc aatccacttc caagctcccc ctgcaaatgc aaggtcatgg   1945140
ctaatcttgt gatgattgcg gaaattacgg ttgtattttt cctcgctatc ctgataataa   1945200
tcccagtaaa ccagagtcac acggtctttg agacggtcta ggtagacacg agtttcctct   1945260
ggaatttcca catcacggtc gtactggcca tccgctgaca tgagtttgaa gaacatatca   1945320
ctccacatct ggcagtggaa accatatttg tcagcaatat ccagcacgcg ctccaagtgt   1945380
tggcacatga ggagactacg atccacaaca ccgttcagaa tcaggtagcg tcccaaacca   1945440
accaagtggg cttcgtccat cccgatattg accttgcgag tcttcagttt agacaacgtg   1945500
gcaaacatgc catcaatcaa gtcataaacc ttttcttcgc caatgagaag aatgtcctct   1945560
acatcacgga gctcctgcac ttccttgaca ccccatttga caaaggccga caagtgggcc   1945620
aaggtctgga tgcatggtac aaaggtcacg tcaaactgtt gggcataggc ttcgatttcc   1945680
tgcaactcct ctgctgaata agctccacgg aaatagccaa agtaaggctg cccttcaatc   1945740
tggtaagtgt cttccatgta aagctcaaag gttgagtagc ccatgagagc caatatctca   1945800
atcatctgct tggcagaagc cacattcagc accgcatttc gagaacagtc aaccatgtaa   1945860
gccaaatctt cgtaagctgc ttgttcctca atctctactt tatcagcttc tgctagaact   1945920
gttaccaaca aggacaaggc acgataaagt tggtgaggtt tgcggtaggt caattgatag   1945980
tgaccttcct caccctcgat agagatagat gcttggtcag actgagtgac agccacttcc   1946040
acatctggta gagaaatgtg accttttaaa acctcaatag cttgcgtttg tttgagacta   1946100
agtcctgtaa atcttaccat tgcttttcct cctgtagcca gttgacaaga gcaccgtaga   1946160
gattggcatc tgcgtgatag gtgcaggcct ggataactgg tgcgaccgtg tattcttcgt   1946220
aggcatcgac aaagtcttca acagccttct tgacaccttg gataaaatct ggattttgac   1946280
tgatagagcc acccagactg atgacacctg gatcgatcag atactggata ttgagcaagc   1946340
cttgcgccag attgcggttc atgcgctcaa tggcttcttg acaaaggata ttaccagctg   1946400
cggcctcttg gtaaatcttg cgaccgtccc aatcagtatg accagatttt tcaatcacgt   1946460
atcgtaccat attcccagtt gatgctagtt gcgaccagtt attaagtttt tcagcagggg   1946520
caagggttgt catgtagcca aattctccac ccagaccgtg gcgacctcga tgaagtctac   1946580
cattgataat catggctccg ccaatccctg tcccaatcac gacacaggct gcattttcaa   1946640
gctctggatg agctagtagt tcactgagtc caacgcagtt ggcatcattt tctaaatgga   1946700
caggtagctg ataagagcta agcgcctcat accaagaaaa gccatggatg tagggcaccg   1946760
cactgaagcc atcaatcaca cctgtctctt gattgactgc acctggaacg ctcatagcaa   1946820
tcccactgta atcctgttct gacaagcgtt gatctagcca cgctagtaaa tcctccaagt   1946880
tttcaggcgt tgaaatactt gtcttatcca gtattttccc atcaggagtc agactggcaa   1946940
acttaatccc agtccctccg atatcaatcg ttgcaatggt cattgttttt accataaaag   1947000
gggcgaatca gcagttagtt cttacttttt cgcccctcct ttcttttgat gtttactttt   1947060
tgaaattaaa tttcttcttt tttgatgaat tctgtacgaa tctcttgtgg agccaatagt   1947120
cctgaatgaa ctgggtatgg tcgttcaagt aggtcaagga agagatgttg actttctggc   1947180
acacgtacat tttcactaca catattgtag taacgaagca catagccttc ttcattttca   1947240
gctaccttaa aggctgttgg acaaacttgc ggtatgctga gaacagaatg gctcaagagg   1947300
ctaccagtcg caaccacgct tccttcctgt ctagcaagct gaaggctggt aaacggtgtc   1947360
tgcaaggctt tggcacgacg ataggctgag aagcgttctt gggcttggtg gcattcaagt   1947420
gcaaactcga cttcaaactc ccgcaagcat tgtgcttctg gcgttgggaa gtagccccag   1947480
tcacctagct cacctgatgc acgcaaaatg gtcacggcaa tggtgttatc cccaaggatt   1947540
tcgtattcat tcaatccctt gttggataca gtcacccctt tttcatcgtc atacagactg   1947600
acaaaagctt gttggtgttg aggattttca gggttttccc atgaagcagc tggtttgttt   1947660
ggtcgtgtca ccacctcata gatactttca gaatcattgc ttggacgcgt gttatgagtc   1947720
ttgaccaaga gacggatacg gtgatccttg gcagtgttag taaagcgagt cttgaagcgg   1947780
atttgtggat tgtcaacgaa gacagtcaac tcagtttcca gaggaatgtt tgtcaattct   1947840
tctgaccgtc cagcctcacg cttcataaac tcgatgatac cttgttgctc ttcttctagc   1947900
ttttcatccg cactgacagg cacggtcaat tcatgtttga gcaagatttt agcatagcaa   1947960
gctgtgtttt ccaagacctc gtggccctta agctctgcaa agattggctc tgttcctttt   1948020
ggttggaaat agatatactc gtttccgatg tccccacggt cttcaaagcg gataaagtct   1948080
tcataggctt cgtgagttgt cttgtcatag actgtgatgt tgtcatccac actcaccgtt   1948140
acgaatggtg tatcaatcac tccgttttgg taaataccct cacggtgttc ttgttttcct   1948200
tccagcaatt ggaaggttgt ccaagaaagc ggcgctaggt gaactggaat ggtcacgcgc   1948260
acttgacgag caatacgagc ttggcggaac ttgtcttttg gtaaattata ctcaaaatta   1948320
gctccgaggt cttcgattgt agcctctaca ggacgaccat ccaagtcctc cacacggtaa   1948380
cttggcaaga taagagcagc catctttttg tagccttctg ttgggtgcaa ttccttgaaa   1948440
tcacaagtcg ccacatcaat cactgtgctg acagtatcga ccttatcatg caagcctgtg   1948500
ttaatgacag taaagagata gtcactttga gccttatccg tagcaatttt acccttccac   1948560
tcgttgagca agttactttt aacaaagttt cctacttggt tgaccttggc aaaacgcgtt   1948620
tccatctcgc ggtgaacttc gtccacgcta cagccacaga tactatcatg tggcgcattc   1948680
tgcaaaagtg ttttccaagc ataggtcaac tggtccttgt ggttgtgtcc accagtgata   1948740
atagtcaagg gttctaccac ttgctctagg aggttgctat tttcttggaa ggcttgtttt   1948800
aggtaaatgc gggatgaaga agtgttggca agtgtgtacc agccatctgt ttcctgactg   1948860
gtcaactcgc ctgtaacagt tgataagtgt tcaggaagcg caccttctac agcttgaaca   1948920
tattcatcaa aagaactatg aacaaagatt acatccggga agagttcatt tgccacacga   1948980
atggcttcgc tcagattttt ctgtacaggc tggtggtcac agccgttcat catcaaccat   1949040
tggttggtcg aagcgtaggc acgcacatct gacaattttt gtttccagaa ggtcaaggcc   1949100
tcatctttgt caactggaat ttcattcccg ttactgtacc agttggcaaa gagaatacct   1949160
aaaacacgac taccatccac accctgccag tacatttctg aaaactgaga cgtaaactgc   1949220
tcatcttcaa ggacttggtt gtcaaatcca atcggcttca caccacgacc aaaggccgcc   1949280
acgtgaatgc ctgatttttg aagaatttga ggcgcttgtc ccatatttcc aaaggtatct   1949340
ggaaagtagc caatctgggt tgatttaccc catttggcag cttcttgttg accaatcaag   1949400
gtattgcgga cattggcttc actggagatc aagtagtcat cctgcaagat gtaaaaggga   1949460
ccaattttaa gtttgccctc gtcaatgtag cgttggacct tgtcgcgatt ttcagggcga   1949520
atttgtaagt agtcatcaag gacaatagtt tgtccatcca agtggaaact cttgaactca   1949580
gggtcatttt caaagagatc aaagagattg tcaaacaatt ccaccaactg catacgatgg   1949640
ctttcaaaag gcaagtacca ctcacgatcc cagtgactat gtgagataat atgtacaaca   1949700
acattttcca tgaagtaaaa cctcattcta aatttaaatt ttaacgtttt aaatgtaaac   1949760
ttgtgattct gataagaatc ggttgagcta aagcgagccc cttagcgaat atccaagtaa   1949820
tccaagacca actcacagaa catcatgtta gcccaggaga accattcacg agagtagagg   1949880
gtcggatcat ctacatgaaa gctttcgtgc atgacacctg taccaccatc gcaggcaacc   1949940
agctgatcca gcaagaattt tttctctgcc ttatctcttg ttgtcaagcc ttggatagaa   1950000
agggcgattg gccagatata gcgatagaag gtatgagaac tgccgagacc gcttgcgtat   1950060
tctccttggt agaagtatgg attttcagag ctcaaaatgg tacgacgagt agcttgatac   1950120
acttcatcat cgaccgaaca gtagcccaga tagggcgcag ctagtagact tggtacattt   1950180
ggatcatcca tgatgctggc atttcctagg ccatccactt caaaagcgta aatcttttcg   1950240
cccttgctgt tggtggtgta agcgtagttt ttgattcctt cttggatttc atcctgaaga   1950300
cgcttggcat cagcaataac actctggcta tcagctaggt ttaatgctgc gaagatttct   1950360
tgcacataac ccaagactac tacagcaaac atatttgacg gaatcaagta actatactgg   1950420
caacagtcat cactcggacg aaaagctgac caagtcatac ctgtcactgc aaagtcaggt   1950480
ccaaagccat catttaccaa ggtgtcttcc ttacggtccg tatctcggac aaaacgataa   1950540
ggagagttct tgtggtcttg ttccaccgtc cacagatgga gaatttcctt agtcgctgcg   1950600
acaaaaatct catcaaactg actagtctcg ccagtctctt tccagaggag ataagccaac   1950660
tgcaaaggat agcaaagcga atccacctca tacttgcgct cccagatcca gccgttaagg   1950720
tctgtgtggt cagtctcgtg gtgccctttc cagttctcct caatgttgaa ggagttagca   1950780
tagggatcct tgagtaccaa ggtcatctga cgtttgacca aacctgcaat ggtctgacgc   1950840
aggagggcat ctcttttagc tacatgaagg tagggtctga gttgggctgt cgaatctcga   1950900
agccacatgg caggaatatc cccagtcaag acaaaagttg aaccatcttc taagatttca   1950960
accgtattgt ccaaggtatc ggtgtagcaa cgctcgaaaa catccaccca ctctggatag   1951020
tccttagccc gctctgctac ttcatctagc cactctctga caatttcttt cgaataaacc   1951080
attttaaatt ttacctcttt caaacaagtt tcatgttcag tatatagctt ttgagacaga   1951140
aaatacatac acaaatgata gtcatttttc tacaaaatag ttatttttga aactcctttt   1951200
ctaaaggccc tctttttctg atataatgta gaaaaacagc taaaggaaag actatgaaac   1951260
cactacttga aaccatcgat acccgctttg gaactaccaa caagcatgcc ttttctcggg   1951320
gaaataccct gccatacaca ggcgtgcctt ttgggatgaa ttactttgtg ccccagacca   1951380
gtgaccagga tggatcttgg ttttttgatc cacatctgcc tatctttcag gggattcgat   1951440
taactcacca gcccagtcct tggattgggg actactcttg gctccttctg acacctgtca   1951500
ccagtcaact ggggggagac agcctctttc accgccagtc ttcttatgat atagataaag   1951560
cttgcttcca gcctcactat ttgaagctct tttctctgcg ttatcagatt gaaacccagc   1951620
tcacaccgac ttgctatggt gcttctattc gtttgaatca aaagcaaggc aaagccctct   1951680
ccctctatct tcacgcagca gatgaactga cagtagagca agtagataag cggactcttg   1951740
ccctgcgaca agaaggtaaa actgaaacta acaaaaattc gctaacgatg ttcactgccc   1951800
tgcaaatgaa cacggatatt cttgctatca gccaagaagc tggagactgg cgaattgact   1951860
tagcaagtag tcaaaccgag atgcaactag ccacttcttt catctctcct tctcaagctc   1951920
taatcaatct acctcaagaa gattttgata gctgtaaatc aagtgcccaa gtggattggg   1951980
aaaatctcct ccatcgtttt gacattatag agacaggaga ggctgaccga accttctttg   1952040
accactgcct ctacagactc ttcctcttcc cacagacttt ttatgagatt aatgaatcag   1952100
ggcaagccat ccacatggat ctggctactg gtactgtcaa gcctggtgtc ctctttagca   1952160
acaatggttt ctgggatacc ttccgcacca ccttccccct ctttgccctt atcataccgg   1952220
agcactatca acgcttttta gaaggtttcc tcaatagcta ccgcgatact ggtttccttc   1952280
caaaatggct ggctccagat gaacggggta tgatgccagg tacactttta gacggtatta   1952340
tcgcagatag cgcctgcaag gacatgaccc ccgacctaga aggagaactc ttccaagcca   1952400
tgctcgaaac agccagcaaa gccgaccctc tcggcatcaa tggccgccac ggactagccc   1952460
aataccaaga actaggttac ctctctaccg accaccacga aagtgttagc catactctag   1952520
actatgccta tagtgacttt tgtatcgcca gctgtgccaa aaaactagag aacatagaaa   1952580
tcgctgaaac ctacaaggct gcttcacaaa attaccgcca gctatttgac gctgagacag   1952640
gttacatgcg agcacgagac aatcaaggaa actttcaccc tgacttctct ccttatagtt   1952700
gggggcgaga ctacgctgaa tgctctgcca ttcaagctac tttaggcgtt ctccacgaca   1952760
tccctggctt aatccaactg atgggtggaa aagaaacctt tagcaactat cttttgaaag   1952820
cctgtcaaga tgctcccctc tttgaaacaa caggctatgg ttacgaaatt cacgaaatga   1952880
gcgagatggc tactgctcct tttggacaaa tagccatttc caaccagcct agtttccaca   1952940
ttccttatct cttccgttac agcgattacc ctgactacac tgcccttctt atcaagacgc   1953000
tccgtcagaa agcttttcac ccaagttggg aagcctatcc tggagatgaa gacaatggta   1953060
gtctctctgc ttggtacatc tggtcagctc tcggatttta tccaacctgt ccaggaaaac   1953120
caagctatga cctcggaatc cctctctttg accatctacg agtctacctc gctaaagaag   1953180
ataaatggct ggatatccat actaaacaaa accacaacca ttttaacttt gtcaaagaat   1953240
gccgactgga caaaacactc gtatcaacta ttcaacacca agacctctta aaagctgaac   1953300
aactaacttt caccctcagc tggttaccaa gtcactaata accaaaagaa cctttgcatc   1953360
gcgcaaaggt tcttctttta tgaaacttgg acttgaagtt gatccacaag ctgaccatcc   1953420
accgttaggt tcagatagaa atccaaggtt ttatctcctg cgaaatacaa ggttggtagc   1953480
gtcagacttt tttcagtctc accagtttga aacgcaagga cttgaatctc atcctgatag   1953540
gcgacaccat ggacacctgt ccccggttga atcgaaatct tagcttctaa aggaccacta   1953600
cattctctgc gcttaactgt aaaataggca ttttctccct ttgccacagc taggcttttt   1953660
tctgcaaatg ctagttcctg aacaacttct ttttttgata atccaggagt tttataaagg   1953720
gaaatcttgg tcaacaaagg caaagcctgt gattctgtaa tgactacacg tatcttctgt   1953780
gcctcaacaa ctgctcctcg taagagacgt ttgtaaccaa cagtatgacc cgaaccaaac   1953840
tcctgccaga caccatccac ctctacttgc acatgaaaag cagcgattcg ttgccctagc   1953900
ttcaaatctt ctcttaactc aattacatca aaagttttag gagaacctaa gtcgagttct   1953960
aactggatgg gcaagtctgc atcgcttgcc caagagctgg tctcaaggcc gtctgtcaaa   1954020
tggcgacaag caaagtctgc ggaaagagct ggaccagata cctcagctcc cagagccaaa   1954080
tcttctttat agagctcatt gcgataggtc gcaaattcat aaagtcgttc aatatccttt   1954140
gcatcaaaga gcccagcttg attcggcgga atattaagca agagtggagt tcctcgccct   1954200
actgagtgaa agtagatttc gaccaactcc tcgagagact taggatcctg atcctcatgg   1954260
tagaaccagc ctggacggat ggaaacatct gcctctccga ttgaaaaaat cgtgcccgag   1954320
ggatccccgt gctgaagata gttcagctct gcttctgttc ctagtttatc aggattcacc   1954380
ttttgccaca gtggatcacc tgcataccct cgttcattgc caatccagcg gatactggtg   1954440
ccttctgttg aaaaaatcaa gcaatcgccc tgcaggtcac gaatggtttc aaaccatttt   1954500
tcaaattcat aattaacctt ttgcgcgccc tctcctctgg caccatccat ccaaacctca   1954560
gcgaacttac cagcattccc atagttagga tttgataaga tttccttcaa ctgagccaga   1954620
taataggcat tgtagtccgc ttctcggtcc acatgataga ggggactatg ggcatcccac   1954680
ggtgacaggt agacccccat atccatatca aactctgtgg cagcttggga tacttcaagg   1954740
agcaagtcgc cctttcctct cctccaagga ctgaccttaa ccgaataatc tgtgtgagct   1954800
gtcggataaa ggacaaagcc atcgtggtgc ttgaccacca aaatcaactt tttgaagccc   1954860
gtttccttga gcacacgaac ccactcacgc gcatccaact gactcgggtt aaagcgctca   1954920
ggatcctcct gtccagtccc ccattcttgg tcataaaagg tattaggacc gaagtggata   1954980
aaagctgcta gttcatctcc cagataagct agctgagtct gacttggtaa cggtccatgc   1955040
ggtttgattt tcttcatcgt tatatatctc cttctttagc aacttctctt attcacaaag   1955100
ttatccacag gttgtggata ataaaccatg atctaacagt cagctctttc caactccaac   1955160
tggtaggctc aggatttttc tcctcaatat tccctcttca aacagctctg tcatatggtt   1955220
ctgctaacac ctctcagaat gctactctcc ataattattc tcaggcttct ttcaggtcat   1955280
tgtgtgaaga ccattcacta tccagacttt tccacagatt gtgaataagt gattattcta   1955340
aactatcacc tcgtcgacta taacaaaaaa taaaaagagg gtcaataaga taattatctc   1955400
ttcctaaata ctcagaaaag attctataat ttgtacaatt gaacaagaaa tgcttctcca   1955460
aaatctatct tcaaaagaat gttgcatctt tttatccttt cacacaaaca tttctcttta   1955520
tacagatcca agtgataacc agatgataat tggacacttt ttgatcattt gtatattttt   1955580
tgaaaaattt tttaaaaaaa ttttatatcc tttttataga agtttatgca tttgtatcta   1955640
tgtattctat cctatgttat gtataataac ataaaattgt gctaaacatc ataatttata   1955700
ttattttccg agaaattata gccattgaca ttacctagga attgcgttat aacatacatg   1955760
taagcggtac ccaaaatggt gccaagtcaa aatttttaag gaggaaaata catgtcttca   1955820
catccaattc aggtcttctc agaaattggg aaactgaaaa aagttatgtt gcaccgtcca   1955880
ggcaaggagt tagaaaactt gttgccggac tatcttgaaa ggcttctttt tgatgatatt   1955940
cctttcttgg aagatgctca aaaagaacat gatgcatttg cccaagctct tcgcgatgaa   1956000
ggaattgagg ttctctacct agaacaactc gctgctgaat cattgacctc tccagaaatc   1956060
cgcgatcaat ttatcgagga atacttagac gaagccaaca tccgtgatcg tcaaaccaag   1956120
gttgctattc gtgaattgct tcacggcatc aaggacaacc aagaattggt tgaaaaaaca   1956180
atggctggga ttcaaaaagt tgaattgcca gaaattcctg acgaagctaa agatctaact   1956240
gacttagttg aatcagagta tccatttgca attgacccga tgccaaacct ctatttcact   1956300
cgcgacccat ttgcaacaat tggaaacgcc gtatcgctta accacatgtt tgcagacact   1956360
cgtaaccgtg aaacactcta cggtaagtat atcttcaaat accacccaat ctatggcgga   1956420
aaagtggatt tggtctacaa ccgtgaagaa gatacgcgta tcgaaggtgg agacgagtta   1956480
gttctttcta aagacgtcct tgcagtaggt atctctcaac gtacagacgc agcttctatc   1956540
gaaaaacttt tggtcaacat cttcaagaaa aatgttggct tcaagaaagt tttggccttt   1956600
gaatttgcta acaaccgtaa attcatgcac ttggatactg tcttcactat ggtagactat   1956660
gacaagttca ctattcaccc agaaatcgaa ggcgaccttc acgtttactc agttacttac   1956720
gaaaacgaaa aacttaaaat cgttgaagag aaaggtgact tagctgaact tcttgctcaa   1956780
aaccttggtg tagaaaaagt tcatttgatt cgttgcggtg gtggcaatat cgtagcagct   1956840
gcgcgtgaac aatggaacga cggttctaac actttgacca tcgcacctgg tgtggtagtt   1956900
gtttatgacc gcaataccgt gaccaataag attttggaag aatacgggct tcgcttgatt   1956960
aagattcgcg gaagtgaatt ggttcggggc cgtggtggac ctcgttgtat gtctatgcca   1957020
tttgaacgtg aagaagtgta atcgctgttc gatattcgtc aatagaaaat gtaaaaaata   1957080
gaaagaggaa ataataaaat gacaaattca gtattccaag gacgcagctt cttagcagaa   1957140
aaagacttta cccgtgcaga gttagaatac cttattggtc tttcagctca cttgaaagat   1957200
ttgaaaaaac gcaatattca acaccactac cttgctggca agaatatcgc tctcctattt   1957260
gaaaaaacat ctactcgtac tcgtgcagcc tttacaactg cggctatcga ccttggtgct   1957320
cacccagaat acctcggagc aaatgatatt cagttgggta aaaaagaatc tactgaagat   1957380
actgctaaag tattgggacg tatgtttgac gggattgaat tccgcggatt cagccaacgt   1957440
atggttgaag aattggcaga attctcaggc gttccagtat ggaacggtct aactgacgaa   1957500
tggcacccaa ctcaaatgct cgctgactac ttgactgttc aagaaaactt cggtcgcttg   1957560
gaaggcttga cattggtata ctgtggtgat ggacgtaaca acgttgccaa cagcttgctc   1957620
gtaacaggtg ctatccttgg tgtcaatgtt cacatcttct caccaaaaga actcttccca   1957680
gaaaaagaaa tcgttgaatt ggcagaagga tttgctaaag aaagtggcgc acatgttctc   1957740
atcactgaag atgctgatga agcagttaaa gatgcagacg ttctttacac agacgtttgg   1957800
gtatcaatgg gtgaagaaga caaattcgca gaacgtgtag ctcttcttaa accttaccaa   1957860
gtcaatatgg acttagttaa aaaagcaggc aatgaaaact tgatcttcct acactgcttg   1957920
ccagcattcc acgatactca cactgtttat ggtaaagacg ttgctgaaaa atttggtgta   1957980
gaagaaatgg aagtaacaga cgaagtcttc cgcagcaagt acgctcgcca cttcgatcaa   1958040
gcagaaaacc gtatgcacac tatcaaagct gttatggctg ctacacttgg taacctttat   1958100
attcctaaag tataatttta gataataaac cgtctaccaa cagctatgag ggctgcgact   1958160
aatagcttta gtccggtcct cttttatgta atggtaatct attatttctt ataaaatatg   1958220
tgaaaaatca ttaaattgaa atctaaacgc attctattga gtgtgataaa ggagaattta   1958280
tggcaaatcg taaaattgta gtagctttgg gaggaaatgc gattctttct tctgacccat   1958340
cagcaaaggc tcaacaagaa gctttagttg aaacagctaa gcatcttgta aaattgatta   1958400
aaaatggaga tgatctgatt atcactcacg gtaatggacc tcaagttggg aatctcttgc   1958460
tccaacattt ggcatcagac tctgaaaaga accctgcctt cccactcgac tcacttgtcg   1958520
ctatgacaga aggtagcatc ggtttctggt tgaaaaatgc tttgcaaaat gctctcttgg   1958580
atgaaggcat cgaaaaaaat gttgcctctg ttgtaacgca agttgtcgta gataaaaatg   1958640
atccagcttt tgttaacttg agtaaaccaa tcggtccttt ctattcagaa gaagaagcaa   1958700
aagcagaagc cgaaaaaagc ggagcgactt tcaaggaaga tgctggccgt ggctggcgta   1958760
aggtcgttgc ctcaccaaaa cctgttgaca tcaaagaaat tgaaaccatc cgtactcttt   1958820
taaataatgg tcaagtcgtc gtagctgcag gtggtggcgg tattcccgtc gtcaaagaaa   1958880
acaatggaca tttgactggt gtcgaagcgg ttattgataa agacttcgct tcccaacgtt   1958940
tggcagaatt ggttgatgca gacctcttca tcgttttgac aggtgtagat tatgtatttg   1959000
ttaactacaa caagccaaac caggaaaaat tggaacatgt gaatgttgcc cagctggaag   1959060
aatatatcaa acaagatcag tttgcaccag gtagcatgct tccaaaagta gaagcagcta   1959120
tcgcttttgt caatggtcgt ccagaaggaa aagcagttat tacttccctt gaaaatctag   1959180
gcgccttgat tgaatctgaa agcggaacaa ttattgaaaa aggataagtt gttttactaa   1959240
taagatgtat tctatttcta gtatctttat atcaaattag aaattattct tgaaaacatg   1959300
tacaatattt caaaagatac tagttttaga ctttaatatg gtaaaacaaa tataaataga   1959360
aagcgttttc ttgaatgttt atttaagaaa gtagttggtt ttttacactt tgttagacat   1959420
caggaggaaa aacaaatgag tgaaaaagct aaaaaagggt ttaagatgcc ttcatcttac   1959480
accgtattat tgataatcat tgctattatg gcagtgctaa cttggtttat ccctgcgggg   1959540
gcctttatag aaggtattta cgagactcag cctcaaaatc cacaagggat ttgggatgtc   1959600
ctcatggcac cgattcgggc tatgctaggt actcatccag aggaaggttc gctcattaaa   1959660
gaaacgagcg cagcgattga tgtagccttc ttcatcctta tggttggtgg tttccttggc   1959720
attgtcaaca aaactggtgc tcttgacgta gggattgcct ctatcgtgaa gaagtataag   1959780
ggccgcgaaa aaatgttaat tttggtactg atgcctttgt ttgccctcgg tggtacaact   1959840
tatggtatgg gtgaagaaac aatggccttc tatccactcc ttgtgccagt tatgatggcc   1959900
gttggttttg atagcctgac tggtgttgca attattttgc tcggttctca aatcggctgt   1959960
ttggcatcta ctctgaatcc atttgcgaca ggtattgctt cagcgactgc gggagttggt   1960020
acaggggacg gtatcgtact tcgtctgatc ttctgggtta ccttgactgc tcttagtact   1960080
tggtttgttt accgttatgc ggataagatt caaaaagatc cgactaagtc actggtttat   1960140
agtactcgca aagaagattt gaaacacttt aacgtagaag aatcttcatc tgtagaatct   1960200
acacttagca gcaaacaaaa atcagttctc ttcttatttg tgttgacatt catcttgatg   1960260
gtattgagct tcattccatg gacagacctt ggcgttacca tttttgatga ctttaatact   1960320
tggttgactg gtcttccagt tattggtaat attgtcggtt catctacttc tgcactaggt   1960380
acttggtact tcccagaagg cgcaatgctc tttgccttta tgggtatcct gattggtgtt   1960440
atttatggtc ttaaagaaga taagattatc tcttccttca tgaatggtgc tgctgacttg   1960500
ctcagtgttg ccttgatcgt agcgattgct cgtggtattc aagttatcat gaacgacggt   1960560
atgattaccg atacaatcct caactggggt aaagaaggct tgagcggtct atcttcacaa   1960620
gtctttatcg ttgtaactta tatcttctat ctacctatgt cattcttgat cccatcttca   1960680
tctggtcttg ccagcgcaac tatgggtatc atggctccac ttggagaatt tgtaaatgtc   1960740
cgtcctagct tgattatcac tgcttaccaa tctgcttcag gtgtcttgaa cttgattgca   1960800
ccaacatctg gtattgtgat gggagctctt gcacttggac gtatcaacat tggtacttgg   1960860
tggaaattca tgggcaaact cgtagtcgct attattgtag tgaccatcgc ccttcttctc   1960920
cttggaacct tccttccatt cctataaaat agtgagtgag gtgattccat gaaaatagat   1960980
ataacaaatc aagttaaaga tgaatttctt atatcattaa aaaccttgat ttcctatcct   1961040
tcagtactca atgaaggaga aaatggaaca ccttttggac aagcaatcca agatgtccta   1961100
gaaaaaactt tagagatttg tcgagacata ggtttcacta cctatcttga ccctaaaggt   1961160
tattacggat atgcagaaat cggtcaggga gcagagcttc tggccattct ctgtcatttg   1961220
gatgttgttc catcaggtga tgaagcagat tggcagacac cgccatttga agcaactatc   1961280
aaagacggct gggtattcgg acgtggtgtc caagatgata aaggcccttc gctcgcagct   1961340
ctctatgcag taaaaagctt gctggaccaa ggtattcagt tcaaaaagcg cgtacgcttt   1961400
atctttggta ccgatgagga aaccctctgg cgctgcatgg cacgctacaa taccatcgaa   1961460
gaacaggcca gtatgggctt tgcacctgac tcatcttttc ctctgaccta tgctgaaaaa   1961520
gggcttctac aggtcaaact tcatggccct ggatcggatc aactagagct tgaagtagga   1961580
ggcgccttta acgttgtacc agacaaggcc aactaccaag gtctcctcta tgaacaggtt   1961640
tgtaacggtc tcaaagaagc tggttatgat taccaaacca ctgaacaaac cgtaacggtt   1961700
ctcggagtgc caaagcatgc taaggatgct agtcaaggta tcaatgctgt catccgacta   1961760
gctaccattc ttgctcctct ccaagaacac cctgctctca gttttcttgc aacacaagca   1961820
ggtcaagacg gcacaggaag acaaatcttt ggtgatatag cagatgaacc ttctggtcac   1961880
ctatccttta atgtcgcagg tctcatgatc aatcatgaac gttctgaaat ccgtattgac   1961940
attcggactc ctgtcttagc tgacaaggaa gaactagtag agttgcttac aagatgtgca   1962000
caaaactacc aactccgcta cgaagagttt gactatctag cgcctctata cgtcgcagaa   1962060
gacagtaaac tcgttagcac actgatgcaa atctaccaag aaaagactgg cgataacagt   1962120
cctgctattt catccggtgg tgccactttt gctcgcacca tgccaaattg tgtagccttc   1962180
ggcgccttat tcccaggagc gaagcagaca gaacatcagg caaatgaatg tgccgttcta   1962240
gaagatttgt accgtgctat ggatatttat gccgaagccg tctatcgact tgcaacttaa   1962300
tcaggcaact gtttctacca aaaaaaatcg accgattaat gaactgcacc ccaaaagtta   1962360
gacagaataa atctaacttt tggggtgttt tattatgaaa ttgagttatg aagataaagt   1962420
tcagatctat gaactaagaa agcaaggaca aagcttcaaa cagctttcaa aaagatttgg   1962480
tgtggatgtt tctggtctaa agtcatctga atctttgaga tgagctttat aaatcgcttt   1962540
tttcagtttt tgcactggtg tttcgataaa ctcaaacttt ttagccgtgg tattgcctga   1962600
ttttatagta tattgaaact agaatagtac acctctcctt ctaaaacatt tttagaaatc   1962660
gatttgactg tcctgatcga tttgtcctgt tcttatttca ttttactata tttgagccac   1962720
ttcgtcttta acggctttat tcataagctc ttgtaatttt tctttactat caattacttc   1962780
tgattttccg ttgtaattta ttgtaatagg ttttaactta cctaatttct cgacacgctc   1962840
attaatttga tcttttttga aggctgctta tgtttttcct aagatttttt caaaaatata   1962900
tttatcagat agcggtttgt cttcttcttc agcttggttt ttgtattaat ttgaaacata   1962960
aggaacaaat ccttcatagt aacctaatgc tcccataagt tcaaaagctt gttttctaat   1963020
tcaaaccatt gcaactcaga tttcagcttt tcagataaat cctgctcatc caaataatga   1963080
cttgaaatta gtgctgaact cgtttctgta tcctgtacag gctgagcacc cataccagca   1963140
aaaaataaac tcgttcctag caagaccgaa caagctccta ttgcatatgg cctcaaagaa   1963200
aaacgctgct ttctctcaaa ttgaaattct ttcatcccat ctcccatcat tcattattac   1963260
tgtatatttt gtatatcaga aatagtttgt attcacaaat ctttctagtt attcccttat   1963320
cattcctaat taagggagat aacatacaat aatttttagt taaatgtata tcgatgtttt   1963380
ttgtttttct taataaacgc aatacaaaaa gagcctgtta ccaagctctt tgtactcaat   1963440
gaaaatcaaa gagcaaatta ggaaactagc cacaggttgc tcaaaacacc gttttgaggt   1963500
tgcagataga actgacgaag tcagctcaaa acactgtttt gaggttgcag atagaactga   1963560
cgaagtcagt aacatctata cggcaaggcg acgctgacgt ggtttgaaga gattttcgaa   1963620
gagtattagt ctattatttc ttctcagcgc gaagggctga caagatttgt gttcggatat   1963680
catccacacc atttggagta tttggtaaaa agatagtttg atttccttta gaggcaaagg   1963740
tattcaaggt atccaaatac tggttggtca agaggataga catgatttgt tcttctgtca   1963800
tgccaacatt ggcttccttg agttcggtga tagactctgc caatccatcc acaatcgcct   1963860
tacgttgttg ggcaatcccc acaccatgaa ggcggtcttt ttctgcttct gcttcagctg   1963920
cagtgacaat tttaatcttg tcagcttccg ccaattcttg tgctgcgacc cgcttacgtt   1963980
gcgccgcatt gatttcattc atggattgct taacttctgc atctggttcg accttggtaa   1964040
tcaaggtttt cacgataatg tagccgtaag tggtcatttc ttctgctact tggtgttgaa   1964100
cttcaagggc aatctcatct tttttctcaa acaattcatc caaggttaat tttggaacag   1964160
aagagcgaag agcatcttcg atataagatt taatctgaga ttctggacgt atgagtttat   1964220
agtaagcatc tgtcacgctc tgctcgttga cacggtactg agtcgctaca ttcatcataa   1964280
cgaacacatt gtccttggtc ttagtctcaa ccacaatatc actttgcaac aagcgcaact   1964340
gaatccgtgc tgcaatcgag tcaatcccaa aaggcaagcg aatatgaata ccgctattag   1964400
caaccttttg gtatttccca aagcgttcaa taatcgccac cgactgctga cgaaccacat   1964460
aaactgtact cagtgtgact atcaccaata ggagcacaca aacaatcaga aaaatcatga   1964520
aaaatattgc cataatggaa cctccacaag tatttttcta gtattatagc acatttaaag   1964580
aaggctgtgc cgtttttact gcgatttttc ctgaaatgtc aataattaga ggtgaattgt   1964640
cctattgtcg tccaatctct tgctaaaata actctttata aaaggcaatc gtttcttcta   1964700
aggttggcat aaatggattt cctggtgcgc aggcatcaat caaggcattc ttagaaaggt   1964760
attcaaagtc gaaatctttt tcttcaatac caagttcagt cagtttctta ggaataccta   1964820
ctgtctcaga aagcttctca atctcagcaa tcgcataatc ggcacattct tgatctgatt   1964880
taccttctac atgaagtccc aaggctttgg caacattgcg gaaagcttct ggtacacgtt   1964940
tagcattttc acgttctata actggtagca acatggcaca gcacacgcca tgtggcaaat   1965000
tatatactgc accgagttgg tgagccattg agtgaacata gccaagacca gcattattaa   1965060
agctcatacc accaaggaag atggcattga ccataccttc acgcgcttca atatcatgtc   1965120
cattttctac agcacgagga agatattcct tgataagctc aatagcacca atagacagtt   1965180
tcttggttac atcataagca ccaggtgtta ccaaagcttc aacagcatga gtcagagcat   1965240
ccataccagt agcagcagtc aggcctttag gtttggaaag catgagttca gggtcattaa   1965300
cagagataag agcaaggcta ttcttgtcaa ccattaccat cttaaccttg cgttcttcat   1965360
cagtaatcac atagttaatg gtaatttctg ctgatgtacc tgccgttgta ttgatagcca   1965420
caactggcaa gcctttttta gcagacttat gaagcccttc ataatcctgt ggttttccac   1965480
catttgtagc catgatagaa atacaactag ctgcatcctg tggagaaccc ccgccaagac   1965540
tgatgataaa gtcacagcca tgttcttgca aagcagctac cccatctgtg acatttttac   1965600
aagtagggtt tggctctaca tcgctaaaga tgacatattc gattccttct gtatccagtg   1965660
gttttaaagt cttaggtaaa atatcactgc cttcgatgta cttatctgtc accaaaagtg   1965720
cctttttata gccaagttcc ttgatataag gacccacttc atttacaaca ccttttccaa   1965780
taaggttgac tgccggaaca taaaatatag ccatataatt ttcctcctgc gcctccgcgc   1965840
tatctattta acatcattat attacttttt gtattcgttt tcaattattt gtgaattgtt   1965900
taacaaatct ttttaaaagg ataggaggga cgtaagttca cctcctatat aaacaagttt   1965960
tatttatgta gtggccccaa caactgacat gcacgatagt ctgctgattc tagatcttct   1966020
gttccaaata aggaccaatt tttaggtcta aagatatctt cctcaggtac attatgcata   1966080
ttgacaggaa ttctcaacat agaagccaag gtaatcaagt ctgctccaat gtgtccatat   1966140
gttatggctc cgtgattagc tccccaatta ttcatgacgt catagacaga cttgaaagca   1966200
ccttttcctg tcaaacgtgg agcaaaccaa gtagttggcc atcctggatc tgtacgatta   1966260
tctaaagtat ggtgaacatc ttcaggaagt tcaagtgtgt aaccttctgc aatttgtagc   1966320
actggaccaa ccccttttag aagattgaga cgtaccattg ttactggcat atcccccttc   1966380
gtcaagaaac gagttgagaa tcctcctcca cggaagtatt cgcggtttgc tggtgggaag   1966440
tctgtatttt caagcatagc ctgcacttca ctttcttcca actcccagaa tggtttcata   1966500
ataggtttgc catctcgagt agcttgacct gtaccatcca atgtacaaga accagagttg   1966560
attagatgta agaagccagc tgcagcacga ccctctaaag tatgtcccgt tacacgttta   1966620
acagcctctg ggctccaata agtacgcaca tcagcaaaga tttgtggagt atttgttaat   1966680
agataattaa agagcataga cacaccattt agtgaatcat tctctgtcgc aaatacaaat   1966740
ggttttcgaa taccattcca gtcaaactga gtattgagga aagtttccat aaagtcccca   1966800
tttggaaaat ggtctgtcca ctgacgttga ccttggaaac cagctactaa agcatggtga   1966860
ccaaccgctt cttcctcaaa accaagttca gcaagtcttg ggttaccaac cattaagtca   1966920
cgtccaatca tgaacatctt aataacaaat tcccattgtc tatctttttc ttcacggctt   1966980
aaaacaaggt cttcacggtt atggtcgaat ccttctttta cgttttcttt cacccatttg   1967040
agcgcacgtt cgaactcttc agggtcgtaa ataccacggt ccatacggcg cgtgaactcc   1967100
gtcatatcta ccgattcatt tcgcattcct aagtattctt ggaagaaatc cggatttaca   1967160
atagaaccac caatccccat cgaaacacta cccattgata ggtaagcagt gtctctcatc   1967220
aagccagttg caagagctgc acgcgcatag cgtaaaagtt tttctttgac atcttctgga   1967280
atatctgtgt cactagcttc ctgaacatct cttccataaa tcccaaaggc tggaatccct   1967340
ttttgagcat gtgaagctag tacagctgca agatagacag ctcctgggcg ttctgtccca   1967400
ttaaatcccc aaatagcatg aggaatatct ggagacatat ccatagtttc actaccataa   1967460
caccagcatg gtgtaactgt aattgttgcg caaacatttg attttttaaa caactcatgg   1967520
gaagctgcag cctctggtac acggccaata gtagatggag aaatcacgca ttccacaggt   1967580
tccccatctg gatatttcaa tgtgcttgaa atcaaatctg ccacactttt agccatgttc   1967640
attgtttgca cttcaagtga ttcgcgtaca ccttgacgac gaccatcaat agtcggacga   1967700
atcccaatac gtggatgttg aatcatacta ttttcctctt atttttctgt ttctttcata   1967760
ctaccatctc cattatattt acggtagcct gggtgataat ttttaaaatt acttataagt   1967820
ataaacctct acctctgcta aacttaaagg aattcctgcg cttctcaaag aaattctaac   1967880
cttttttccc ttcagtcctt ttaagtctat ggatagatta ttgctttcta aactgtcaat   1967940
atgttgtgta aaaacttcat aatcatttga atcatatata ataatatcaa aatttgataa   1968000
tctctgaatt tcagcatctg ttctattata aataattaac ttttctaatt cttcggtttg   1968060
tgctaaatct atctcccacc atgaaggaga atcttctttg gtatgagtca ctgaatgatg   1968120
accataatct ccgtttttat ttccatcaac tgctagacga gaaaaaccat tgtaatccgt   1968180
tgaactctgt cgagtttctt ttgttaatgc aatattagaa agtttcttcg gagttctctt   1968240
tgaaccatag acttcaactt ccgctaaact taacggaata gctgctgatt ttaattctat   1968300
tttgactagc ttagccccta cagaaggtac ttttaaagat aacaaaccat caactacttt   1968360
atcaaaatgt cttctaaaaa cttcttctcc tgatgaagat agaaaaataa catcaaaatt   1968420
agataaacgc tgaggttcgg catctgttct attataaata tcaactttag aaaccgtaaa   1968480
ctcttctccc agatcgacct gccaccaagc gttagaatct gccttagtat gagtcaccga   1968540
atgatgtccg taatctccat ctttattacc atcaactgct aaagcagcta caccctcata   1968600
attggttgaa ctttgagtag ctaccttatt tgtagagact actttatctt ctgttatttt   1968660
atctatatcc tcttcagatt gcttaccatc tgattctcta aaaacctcta cttctgctaa   1968720
actcaaaggc actccactcg ttagtaattt aactttaata taccttgctc ctttttcttt   1968780
gaaatctaga ctaacagatt cacccgacaa attattaaca tgtttcttag caacttcgtt   1968840
tctattattg tcatatagaa tcacatcaaa attagataga cgttgagtct cagcatctgt   1968900
gcgattataa attttaacaa gcccaacttt atccattttt ttcaaatcga cttcccacca   1968960
agagggatta tctgccctag tgtgtgttac cgaaccagag ttaaaattac catttctgtt   1969020
accatccaca gctctattag ggtctccatt gtaatctaca gaactttgtg ttgttggttt   1969080
tgcatatgct atattcaaat taccatcatt aaatttatct ggtgttggga aagagactgg   1969140
acctgtcccc tcagtattta tagacatctc taccattcca ttatgattaa ccgtaatggt   1969200
ataaacatgg gtattctcat cccaattttc tgtataagta taatgatttt tatcgccact   1969260
tatatttatc tgaggtttat gaccagtatg cccttttaat gtaagtgttg ttgtcctaaa   1969320
gtcattatct acaggattga tggaataatt tttgcttatc cagttcgcta actctaattc   1969380
ttctttcttc caactttttg atgcatcaaa atttcctgat aatgcccaca tagctgtctt   1969440
atctgtcctg taattattca ataaaatatg taaattattt ggattttctt taacaacagc   1969500
gtaagtatgt ggcgtcaaat ctaacgataa cgactttgta ttattagtat acataggcaa   1969560
cattacttgc tgatttttat tgatattagc attactatta taaatatacc aggaattacc   1969620
tacacgctga gcatacccat ctccttcata aagttttgga taaagcgagt ttaaatagtt   1969680
gactttacta gacaattcct cactattttt agtcaaaatt tttgcattag ggaatataga   1969740
tgaaatcttt tccttatcaa ttttctcatg tattacagga agaatatgat atctcccatt   1969800
attatataaa ggcattgttt catcattcga ataaagtcct tgataaaatc cgtttaatga   1969860
actaatccta ccttctccat tccaaaatac agcttttgtt ctatttacaa cttcttcctt   1969920
acttggagct ggattttgta tagcatgtct aaagaaagga ataatacctt tagtaaatgc   1969980
tggagttggt acatcatttg tcataaatgt atacgcggca cattcgaaat tataaactgt   1970040
gcctccccca gtatatacat tcatcatttc catagcaatc attgattctg gttccgatgc   1970100
ataggatctc atatccctag ctcttccagt ttcaaatgtg tttgtataat gtttttccca   1970160
ccatttccat gtatctgttg atgagcccca gttatcacat aagccactca accaaaatcc   1970220
actaacgata gaatctgtac ccgcatcatc tcttattggc gtatttttag ttgccaacac   1970280
caaattttta tgatattttt gactcgcttc aaagaatgtc ggatcattca taatagtttc   1970340
ccagaaccat ttttcatgat catgccagat aaaatgcgct ccatatttgg cacaaacttc   1970400
caaatattta gcactatgcg gagctaactg gttattgtaa atccaataat tctcaatatt   1970460
taaaacacct tttaacacac tatacttttg gaattgttca tctaaccact ctggaggaac   1970520
tgtattacgc tctccagccg acataataac caagaaaact ggaatgttta gactttgagc   1970580
ttcctccaac atcttgacat accattctct caattctttc gtatctcgtg gaatacaact   1970640
tgttggttta cagacttttg caggatgaag ttcaatcgct gcatatggct ttacatcttc   1970700
aggaatagct tcccatgctc ccttcaatgt gttcccccac cataatccgt taccattatc   1970760
attgccatac aacggagaaa gcaacaatgg cgattcatta ttaatcgtcg ttctcatttg   1970820
aacacgatta tcagccttaa ctcctgctaa caatccaaaa cataacatcc caatacatac   1970880
aaacaatatt gtgattaatt ttctttttat tttttcttta ttcatgactt atacctaaaa   1970940
atttaactca ataatttttt ctgaattaaa taccaattca atattttgta catcagtatt   1971000
tttgccatat attcttactc ttactttttg atctttgttt cctccttcca attttaggaa   1971060
tgttatatcc ccatttttcc aagcaaacga taccttatat cctcctctta ctctgaaacc   1971120
tttcacttct ccttctgacc aagcagaagg taaagctgga attagtgata accaattatg   1971180
atggctctgt actaataatt cacaaattcc actcaccaaa cctaaattac catcaatttg   1971240
aaatggtgga tggtcaagaa ataaattgcc aagagtcgca ttatttaaca aaccattaat   1971300
ctggttataa gcaggttcac cttgatatag tctcgcaaaa aaatgaatca gccatgcagc   1971360
actccaacct gtttgtgtac tagcatgcaa accacttact aaccaattat taatcgcttg   1971420
ctccctctcc tgtgaagata aaaaattagc gtttgataat ctcctattga tagtgatttt   1971480
agctgcttct gctaattccg gagttttatg aatatcaatc tcattataag gataaagccc   1971540
aaatagaggt gaaatgtgtc tatgcccagg ctctacttct tcataatctt ctaaccattc   1971600
ttggatttgc ccattactac ctatttttgt tttaggtagt ttctttttta actccttcac   1971660
acgactaata aaatccgaat tgtctcctaa ttgttttgca atgccaatgc atgaatcaca   1971720
aaaatatctt agaatttgat tatcaattgt agatgataga caagcatttc cttcaatacc   1971780
attttttaag cgatatttat tttccggtga gacacttgga cctgtcatca agtagccatc   1971840
cacctcaaat aaataatctt caaagaaaag aaatgcttct tttatcattt caaaatgttc   1971900
cgtaagaata cgctcatctt ggaaatataa atagtgttcc caaatatgag tacataacca   1971960
tggaatagtt aatacccaaa ttgcagcccc catggcatga gattggggag ccgtatcgcc   1972020
aaaaccatcc gtattatgat gtgctgtaaa acctctagct ccatacattt tcttagcggt   1972080
tagtcttccc ggttctctca ttctttcgag catatcaaat aatggatatt ctacttctgg   1972140
taaatcacat ggacctacca tccaataatt catttgagta ttaatattaa tcgtatattt   1972200
agaaccccaa attggattta attcatcaca ccatattcct tgaagattgg caggtaaacc   1972260
attcggttga ctagacgata ttaacagata tcttccataa tgaaataaca agttagtcaa   1972320
gtagttacta tactttttag tgttttcaag aagtagattc gttggaatgc taagacaacc   1972380
tttactatag tctagtttaa aatcaactct attaaattgc tcctgatatt tttttacatg   1972440
ttcatctttt tctgtaaagt aatcaatact actaaattct ccctgaagag aagaaatatc   1972500
tatatttccc caataatccg tcattgattt gagataaaga aatacctctg tagcattccg   1972560
aataactatt gtctctccca atacacttac ttcaccatcc gtaaccttag aatgacatac   1972620
tactttaaac tgaacacctt ttctacctcc agcagaggcc gacattaaaa ttgtacttga   1972680
atccagttta gatacttcgt cattaaaccg tttatttcta cccaaattaa tgtttaaatt   1972740
taatgtgttt tgaactgatg acactatacg gcaacataaa atattcttat taaaactcgt   1972800
aaaatattct ctttttattt gtaaattaca actattaggc tcaaacacaa cattagaaat   1972860
agctgtatct aaatctagct ctctttcata caatgaaaga gcacaagact gaatatctat   1972920
atgctcaatg taaagttccc caagtaattc atagtggctt tgatctcttg gggtagcaaa   1972980
cactgttaac tttatcaatt cttcggcttt ctgaatttct ccatctaaaa gatattcccg   1973040
aattttttta agatgcaata gtgagtctgg attatttcta tctgactttc ctctatacca   1973100
aatagtctca tcgtttagtt gaatacattc ttttgtagct gaaccataaa tcataccacc   1973160
taaatgaccg ttcccaatcg gcaaggcttc attccaattt gcggcagctt tcttatacca   1973220
taatttcact ctttacctct cttccaaaat ggaggtgata tcccaaatac cacctccaca   1973280
ctttctacta cttcaaaatt cctaaaacaa ctagaataac tccaatagcc ataacactaa   1973340
agattagtac aaccggattc tttccttttc taattaattt acacattaat aaagtcaaag   1973400
ccatagggat aaatcctgga attaattttg taatcatttc ttgaacagaa ataacaagtt   1973460
ccccctgctt aaattctaat ccaaaattaa taccaaccat tgatggaatc aaaccaccca   1973520
ctagtactag ccctaatgct gtcgccatac tcgtaacgcg attcaatgtt ccttttgtat   1973580
tattttcttg gataagacta gaacccttag tatacccata tttcaaaccg aaatatttaa   1973640
caggaatatt aataatatta aacaatatta aggcgataaa gatacctaaa gcaccgccgt   1973700
ctttagaata agacgcacca atactaaaac agataggaac tagtgtcagc cagaacaaac   1973760
tatctcctag accagccagt ggccccatca agccaacttt aataccagta attgaagctg   1973820
caccttcatt tccttcttgt tcttccatag cggaagtaac tccaagaata aatggtgccg   1973880
ctgtttgatg agtattgaaa aactcaaggt gacgtttcat tgcaggagaa gctgaatctt   1973940
tgtctgggta tagttttttc aatactggaa gaattgtata tagaaaacct aggttctgca   1974000
ttctctcata gttccatgaa gaaccataca taaaacttcg tttgaaaact tttttaagtt   1974060
caactttagt tactttatta ttcatcatag atcaagatcc tcctcaacat cactacttga   1974120
agttgtttct tgtggtttgc ttccaatcat atcgtagaag tatgctaccg caataccaac   1974180
tagtgagatc ccaatggttg acattcctcc atacacagaa caaatgaatc caatcaacaa   1974240
gaatacccac atatttttct tgagcatcat atttaaaagc ataccaaaac caattgaagg   1974300
tagtaaagca cctgcagagt taagtccctg cataacgatt ggtggaacct tagcaaacaa   1974360
gtctgccaca tattcccctc caagcataat agctaggaaa attggtacaa ttttaaataa   1974420
cgtgattaaa accaaacttg aataatgata aaaaccgatc tttgaataat ctccgttttt   1974480
agcatcatta tcagcttttt tcacaaaata aacatctaaa gtttttgcaa gaacatccaa   1974540
ctgttgggta gcaactgcaa ttggaactgc tatagcgata ccagcagttt ctccttgacc   1974600
agataaaata ccaaatgcag taccaataat cgcacctgaa atagtatctg gtggagtata   1974660
acctccaata cctgttacac cgagccaagt taattcaaga gctgaaccaa taagaacacc   1974720
ttgggtgaaa tctcctaata ctaagccaac cattgcactt gtaactaacg gacggtgaat   1974780
cataaataac ggtccattat agtcaatagt ggcaataatc ccaactaatg tcaccagtaa   1974840
tgcttgtgtg aatagcatat actgtacctc cttaaattat ttttataaaa atttttccaa   1974900
cattgtaact ttatcattag gaaccatttg aatttcaact ctcgttccct tatcaactat   1974960
tttcttaaaa taatatttgt cttcttcacc tagagctaca cctcccgtta ccttttcatt   1975020
ttcctccgtt ttactcatct gtcctacatt gaggtactcc aattttaaat ttccttcaat   1975080
agaatcatac acatcttttg gatttgtata tatcagcatt gttctctttt ttattggcac   1975140
agagtttaaa acttccacaa accgttttac actaaagaaa acaattttta aacctaccgg   1975200
tgcagaaatc tttaaaatag attgtcgtgt tttatcttct gagatgcgat cattaacaat   1975260
gataacttgc tcaatatcat acttttttag ccacgtagtg acaacttgac catgtaccag   1975320
acggtcatca atacgaacaa actctataga cataaatctt cttcctcctc tacgttaagt   1975380
tgttgtttaa cattaaacaa actattttga gcattgtgaa caatttcttc taaattgatt   1975440
tttgaatcat aacttgatat taattccact aggagaggga tattaaaccc tgttacaata   1975500
tcaactgaat ccaaatttaa aaaccgtgac aaagccacat tattaggact tcctccaatc   1975560
aagtcagtca aaacgataac ctcttgattt gagtctaaca gttcatccac ttgattttta   1975620
aaataatgct caaactctac aatattctct ccaggcatca aacctaatgt cctaactcta   1975680
tcatttgttg tctcaccaac aaacatttct gcggtcatga gagctccgct agcaaaatta   1975740
ccatgactgg caactaaaat tcctctattg aacattttct ctttcaacaa ctactccttt   1975800
cttaaggata atattagcat aaagtgaagt ttctcctgta gcaacaatag cataagcttt   1975860
cttactacgt tcataaaagt cttctcttct aagataagta atcgttttaa gatctgtacc   1975920
atgaccttca atcatctgtc tataggtacc ccatatctta ggaatatcat cacccgaaac   1975980
aacgttcata aactgaattg aactatcgac gtaactatct aatggcatta aatacagaat   1976040
ggaatctaat aattctggaa tatttacacc atcacaacga attagcttat ttgcacatga   1976100
ggcagaagga taattcgcgt cagctaatac tatttcatct ccatgtccca tttccattaa   1976160
agtcttcaat aaatctggag aaatattttt cggtatatgt tttaacatta atatcctccc   1976220
tattttctct gaccgtatgt tttaaatttt tctgccatca attccatctc ctcatcagga   1976280
agaactactg gctctccaaa attcttagct aaacaataaa tttttgcaca atattcaact   1976340
tcttcaacaa tattaaatgc attcaataaa ttttgtgcac ctgctaaaat tccatgattc   1976400
gctagtaaaa ctgctctacg accttccatt gctttagctg cattcacagc caattctttc   1976460
gtgccatatg ttgcatactc agctacccga acatctttcc ctgccactgc aatcatataa   1976520
tgactcgctg gaagtggttc tctgagacaa gctaatactg ttgcataagt tgtatgagca   1976580
tggataattg catcgatatc atcacgagtt tgatattgaa tcaaatgcat ataccattcg   1976640
ctagatggca agcgttctcc ctctacaaca tttccattaa tatccatcac tacaatatcg   1976700
gattctttga tttcaaagaa atcaataccc gacggggtaa ttgccatcaa ttgtttttca   1976760
cgatcgaaaa cgctgagatt cccacctgtt cctttcgtca aatctgtttc tactagcttc   1976820
ttaccatatt taattaattc ttgttttaca tctgacatcc ttgtcctcct catatcaaaa   1976880
cactaaatat ttttcaattc accaattatc cccccttcct gcacaaaagc taagaagggg   1976940
gagggaggca aatttacaaa ctctcaatct ttttaattct tttgggagta ataactctct   1977000
aattgtagaa actcctcaat aacatggtga gcctcttcca tcccttttaa ttgtcccata   1977060
gctatgagct gcacaacaat attccccaca gctgtagcct cagtcaaacc tgtaagaacc   1977120
tctttaccag ttctatcagc aatcatttgg ttaaagtaac tggctctagc acctcctcca   1977180
atcacatata tcctcttata aaccttatga gttagttctt ctagtaactc tatcgctttc   1977240
ctatacgttt cagctaggct ttcataaaca atcttaaata gttgtccatc tgtccactct   1977300
ctagtttcat gatgataagc tagatattct gtcaaagtct tgtgcatatc agattctgtt   1977360
gcaaattcag ttgattcagt atcaatcaga ggaagatttt ctttttcttt ctccaccatt   1977420
gtcctaatat catcaaaaga ataggctttc cctcttcgtt caaatgaacg tcttagttcc   1977480
tctatgatcc acaaccctgt acaattcttc agaaatgtaa tcactccatc tttaccgact   1977540
tcatttgtaa atccataact gaaggattcg gtagtaagaa tcggtgaagt aagttccact   1977600
ccaaccaaag accaagtacc tgatgaaata aataaactac cttctgtctt aggtactgag   1977660
acaatcgcgc ttgctgtatc atgactacaa acattcacaa caggaatatc gcctaaacca   1977720
tactcctctt ttatccttcc aagaacattt ccctctgaaa caatttcagg aagtaaagat   1977780
gaatccaatt caaatagttt taagatattc tgattccaat tttgactcct aggatcaaat   1977840
aattgagttg ttgaagcaat gcttttttct gtagcaaact tacctgtcaa gagataatta   1977900
aacaaatctg gcattaaaag aatcttattg gtcttataga aagagtcagg agattcttga   1977960
cgtgccttaa agagttgaaa caaggtattt atctccataa tctgatttcc tgtctctgaa   1978020
tacagttttt ctaattcagt catttcagat atttccttta acactccctt tgttctttca   1978080
tcacgataat gaacaggttg taataacagc ttaccttcat tatcaatcag tccaaaatca   1978140
actccccatg tgtcaatacc gatagataaa atcttgtaac tagtattagc caagcggata   1978200
ctttcaagaa ttttagctag tagaaagtca atatcccaag ataaatgccc ttttactcta   1978260
ataggtagat tagaaaagcg atttatttct tccattacta gtttattttc agaaaggtaa   1978320
ccaacgattg ctcttccaga agtcgcacct aaatctattg ctaaaaccgc ttccattttt   1978380
cttctctctt cgtccttgat taactttatt ataatcccca cgttttattt tttcaatatg   1978440
tgaacgctta cttgaataat gttcaaatgt taacccaata ttcataaaaa taattcaaat   1978500
tcctccaatt tgtgctataa tatagttgaa atgataaatt aggaggagct tatgataaaa   1978560
gatgaacgtg tacttgaatt gattgaaatt atcaaaaaga aaaaaagaat tgccgtaaaa   1978620
gagctggcag aaatcacttt ctccagcaca agtaccttac gtcgtgattt aattttctta   1978680
gaaaatcaag gtcttatcaa aagaaagcac ggatacgtga ccctgtcctc tatgaacaca   1978740
attgaacttt ctcatcaaat acgtgaagga gaaagtacta ggcaaaaaag actaatcgct   1978800
agtctcgcta aagactttat tcggtctggt atgtgtatct atctagattc tagtactact   1978860
gtctacgaac tctgtcccta tctttctgaa cttgataatt tgattatttt tacaaatggt   1978920
ttacatactg cacaaaccct atctgaaact gttaaagata gctccaaaat ctttatcaca   1978980
tctggcgagg tcaaacatca atcctgttcc gtggtcaact atgataagga aaattcttta   1979040
ttagatcatt ttaatatcga tttagcattt tgttcagcaa gaggtattga tgaccaatat   1979100
gtttatgaag cttctctcag ccaagctatt tcaaaaaaga atattattga caaagcccat   1979160
gaaaccatct tactgattga tagttctaaa ttttacaaga ctggattttt taaaattaat   1979220
cccctctcca aatacacaac ctttatttca gacaccgtgc cagatcaaaa attattagac   1979280
gcagtcgaat tatttgatgg agaatgggtt tctgatattc aatgaaaatc aaataggaag   1979340
ctagtctcag cttgctcaaa gtacagattt gaaaattgat caagtcagct cgaaacactg   1979400
ttttgaggtt gtagatagaa ctgatgaagt cagtcacata tatacggaaa gacgaagctg   1979460
acatgatgtg aagagatttt cgaagagtat cgttctgtct gctgactgat ttacaaatat   1979520
tcaccacatg acattatttt cttagcaacc ctaaaaacag aggctggaca aaaactcaat   1979580
ttcaggagaa aatggagtaa accttcccac aataaaacgc atagtatcaa gtttttgcac   1979640
acctgatatt atgcgttttt ctgattttaa agatttttct cttagatctg atatttcaag   1979700
aattaagtga ccttgatgat ctaaatgtat tgtggtatac tatttttgtc atcggttacc   1979760
gattacgttc ctatgggttc gtgagaggag gtgaaactaa tgagccttat catagagctc   1979820
gctcttacta ttatagcgga tgttatagct ggaattatct tgtatttcgt ctgcagatgg   1979880
ctagatagta aggagtagac cgactgacta gcctataaac acccgttaaa tcgctaagat   1979940
acgtcaaaaa agcccttaac tacggccata gttaggggct ttggtgttct aatgaacctt   1980000
atcaattaac tacattctag catataatct acaatagttc aagcattaag taaggttgat   1980060
gacctgaatg tagtgtgata tactattttt gtcatcggtt accgattacg ttccttacgg   1980120
ttcgtgagag gaggtgaaac taatgagcct tataccagag cttgctctta ctattatagc   1980180
agatgttata gctggaatta tcttgtattt cgtctgcaaa tggctagatg gtaagaagta   1980240
gaccgaatga ctagcctata aacacccgtt aaatcgctaa gatacgtcaa aaaagccctt   1980300
aactatggca ctagttaggg gctttggtgt tctaatgaac cttatacact aactacattc   1980360
tagcatataa gcccagatat ttcaagagtt ttatttattg tttaaagttc tgaaaggtct   1980420
ataatgaagt tagccatcta gtatcaaaaa accgactagc tcttatgaac tagtcgattt   1980480
ctcatcaatg cgccaacatt tcttgggcga tttcttggcc agataggtta tctgggtagt   1980540
aggttggcca gttgtccatt tcttcaaaga gggcttcttg gcttgtgcct ccaaagaaga   1980600
tatggaaatg ttctgcctta actggggcaa cattgtggtc actaaactga acatacttga   1980660
attgtccagc gtcagcatct gtggcttcaa agaggaaacg cacgccacga ttgcctttct   1980720
tgtaagtcaa aattttctta ccgacatact tgtaagtgta tttcttgctt tgtccacctt   1980780
gaacaaattc catagtatta tcagtaatgt taatcttagt cacatctgta tgatagcctt   1980840
ttgtatagta agccttgtac tcagcctggg tcatcttacc agtcaactta gccttgtagt   1980900
caaagacttg gtcaaacgtg ccgtcttcaa ggaaaggata aactgattgc cagttacctg   1980960
catagtcact caaggtgcgg tccttgacag ctgcatcctc gaagtaacca ttttggactg   1981020
tcttggtatc ctctgccttt tcaggttcaa ttgctgggcc ttcttggtct gttgtttgtt   1981080
tcaaagcctt gaggtttttc tccatcacgg aaatgtagtt ttctccagcc ttggtgtcct   1981140
cttctgtcag actttctaaa ggattgagga catcagtttt gacacctgct tcttttgaaa   1981200
gtgtgttagc aagggcttgt gaggcatttt cttcaaaata gatataggcg attttatttt   1981260
tcttgacata ctctgtcaat tctgccaagc gagcagctga tggctctgca tctggagaaa   1981320
gtcctgagat tgcgacttgt ttgagtccat agtccaaggc aagatagtta aaggctgcgt   1981380
gttgagtcac aaagctcttt tgttttgctt gagacaaacc ttctgcgtaa gccttatcca   1981440
aggcttgcaa tttttcgata taggcagctg cattcttctc aaaggtctct tttttatcag   1981500
gataatctgc tgacaagctg tcgcggatgt gctctactag tttaatggca cgaactggtg   1981560
ataaccaaac atgggggtca aactcatggt gatgaccttc ttctccatgg tcatggtctc   1981620
cctcttcttc ctcgccacct ggcaagagca acatatcgcc tgtcgccttg atggttttca   1981680
cttttttctt atccaaggta tctagcaatt taggtaccca tgtttccatg ttttcatttt   1981740
cataaacgaa ggtatctgca tcttggattt tggcaactgc cttggcagat ggttcgtatt   1981800
catgaggttc tgtcccagca ccgattagga gttctacatt agccgtatct cctgcgactt   1981860
gcttggtaaa ttcatagaca gggtaaaagg ttgtcacgat attgagttta ccatctgcct   1981920
gtttttgatt ggaacaagcc actaaaaaca aggcacatag actggctagt aataagctaa   1981980
tttttttcac gttcgtctcc tatttgataa aacgtcttac taaactgatt agtataaaga   1982040
cagttacaaa aataatggta atacttgcac ttgcaggtgt ttctgcatag taggaaatgt   1982100
aaagtcctgc taccattccc aaaaagccaa tcgcactggc aagcagcata accgatttaa   1982160
agtttttccc cagacgcagg gcaatactag ctggcaagac cataatggtc gataccagaa   1982220
gagctcctgc tgcaggaatc ataagggcaa tagccacccc tgtcaccatg ttaaaaagaa   1982280
tggacatggt acgaactggc aagccatcca caaaggccgt atcttcgtca aaagttaaga   1982340
tatacatagg acgaagaaag agaaaggtca aaatcaaaac aaccgccgca atgacaaaga   1982400
gggaaatgac ctgttcttca ctgatagtca cgatcgaacc aaagagatat tggtccaaac   1982460
tcattgaact cgagctttta cccttgctca tgacaatcag agaaacagcc agacctgttg   1982520
acatgaggat agctgtcccg atttccataa agctcttgta aaccgtacgg agatactcca   1982580
gaaagaccgc cgcaatcaag acaatggcaa tagtagaaac agttggagaa atccccaaaa   1982640
ccagaccaaa ggctacacct gaaagtgaga cgtggctaag ggtatcactc atcaaactct   1982700
gacgacgcaa gatgaggaag gttcccaata ccggtgagaa aagactcata gcaataaccg   1982760
ccaaaaaggc gcgttgtata aagtcgtaag ataataaact aagcatggcc cacctcctgg   1982820
ccattctcat gaacattgaa acaacgccat ggcgagtctt ggttacggac tagatgaata   1982880
ttgcgatccg cataatcctt aacttcttca gggtcatggg taatcatcaa aacagccttg   1982940
ccatgatgat gggcgctgtg gtgcatgagt tcgtaaaatt catttttact tcctgcatcc   1983000
atccccgttg tcggctcgtc taggataaac acatcagggt cagaagcaaa catacgcgca   1983060
attaccgctc gctgcttttg tcccccagat agagacccca agcgtttgtc tcgatgttcc   1983120
cacatgccaa ctgagtccag actagccttg atatgctcct catcatgagc attcaaacga   1983180
cggaaccagc cttttctcgg atagcgaccc gacttgacaa attcatagac cgtacttgga   1983240
aaaccagcat taaaactggc aatttgttga ggaagatagg ctattctcaa tttcttacct   1983300
tgcgtatttg tctttgaaat agccaccttt ccaatgcgtg gttgcagaat tccaagacta   1983360
gccttgatga gcgtcgtctt agccgctcca ttttccccag tcaaggtaac aaattcccca   1983420
ctatcaacac aataattgat atgttcaaga acaggctcct tatcataata gaaggacaaa   1983480
tcctctaccg taatatatct cattatttga tttctcctac taaagcagtc aaaaaccgct   1983540
gaatcacttt ttgttcattt ggagtaaact gagtcgccac ttgttcatag gttaaaagtg   1983600
tatgctcatg gtgatggtgg tgctcctcag cgattggacg agccaagtca gtcaactgat   1983660
aaaaaatcac acgcgcatct ttagaatctt tagatgtttc caacatccct tccttgacca   1983720
aagacttaat ggccttggta actgccgcct gactgacatt gagacgacgg gccaattctg   1983780
aatttgttaa agattcctct gacaagagca taaggatatg ctcctgagta ttggtcaggg   1983840
ccacctcgct agtgcaatga cctattagga tttcatgctg attttccgcc tgcaaaatca   1983900
cctcattcaa aaaagcattg atatcctttg ctagctgtct catatctgac tcctttcctt   1983960
ttagacttct cttttttaag agaaaaatac tattctttga cattttgttt accagttaat   1984020
tatatcacaa gcaaaaaaag agtcaagaaa aaacgtgaaa actagtttca ttcttgaact   1984080
cttctatatt atattatcta ttgaaattct ttgacatctc catcataagt cgcccaatct   1984140
ttgctgaaaa agcgctcatt cagatggtaa gtcggagctg gtgtgggatt ggataggaaa   1984200
ggatcaactg ccttgtcaaa agccaaccaa cccaaccaac caaggtgaat ggtgtccttc   1984260
ataaagaaag gctccccgcc gtccttagaa aaatctgcta tattggtaaa accttgactt   1984320
tctaactggt agcgaatctt ctgcaccgtt tgttggtaca tatcctctcg tagaccagca   1984380
tagttcatcc attttttatt aacaggtgga atgataaaaa tcgggtttac cttagattta   1984440
gaaaactgtg ttaaaaccaa ctgcaagtca ttatactctg gcgacttgag ataggtaaag   1984500
cttttctgag aatcctttaa tttcttcaaa tccttcttga tctgctcatt atagaaataa   1984560
ttttccattc ccatctcatt attggaagta tttttttcag catctgcttt gacaacatct   1984620
tctattgcct gataagaaaa ctggtctggc aagattttta aatacttagc tacatgctta   1984680
tcgtagttaa catagcctct aaccgaaaac tgaccaaaaa aggaagcttg gcgttcatta   1984740
aaacgagcca ataattcaat catttcattg tctgctgtcg acaattcttc tttacttgcc   1984800
aacttctgaa ccaggtcctt catagctacg tttgggaact gttgcagtaa gcgagtcgct   1984860
gcatattgac tagcctgatc cccagattga tgtttcagaa aactagtcaa ctggtctcca   1984920
ttaaaatact gctggaaggc tgctggatca tagccatttt tactgaacca ctgaggtgag   1984980
ataacataca caacttgttt attctccagc tgtggtaaca tctgttgcat tccaaaatat   1985040
tggttaagcg atgcagctcc cccctgtcct aaaagataag gacggtagga acgattgtat   1985100
ttctcagcta ataccgcagg atgagcaccg tcaaaacgaa gccattcact agagccaaag   1985160
aagggaacaa aacgcacatt tggatcagat agtgctctga ctttttgact tcgctcctta   1985220
aaactatcga tagtagtagc cactgctgaa cgcttttcag ctcctagatt atgatgcatc   1985280
tcagtaggat aaaagaaaat gagcagaaaa accaacaaac cagcgatcaa gaccggtccg   1985340
aagatcatcc ataagcgttt aagcattttg tagctccaca ataccagcta tgattttatt   1985400
agctgtattc cagtcgtcac gaccaaactc tgttacaggg acacgaatgt caaaacggtt   1985460
ctcaatctcc acaatcaact caaccgttcc catactatcc aagacacctg catcaaaaag   1985520
atcttcatcc atcatgtcag aaacatcttc cataaacaac tcatcaataa tttcaataac   1985580
ttctgatttg atatccatat tttatttcct tttatttttt aaaccataga ttattcaaga   1985640
atccagaaaa gattaagaat gacaacatga caacatggaa agtgacaacc atgccaagca   1985700
actgaatcca gcgattctca ggtagggcag ccttccctgc ttttttccgt tccttattga   1985760
gcgttttttt cttgcgaacc caggcatcat tgatgaccaa gcctagtcca tgaaagagtc   1985820
cataggcgat atagtaccag gtcacaccat gccaaaatcc cataatcagc atatttacaa   1985880
tgtaggccat gcttgaggtt acattacgat ttttaaagac tttctttctg gttaacacca   1985940
tcaccattcg cataaagaca aagtcacgga accagaagga cagactcata tgccagcgat   1986000
tccaaaactc ctttaaatcc cttgataaaa agggcttgtt aaagttgata gggctacgga   1986060
ttcccatcaa gtttgagatg gccaaagcaa acatagaata acctgcaaag tcaaagaaga   1986120
gttccagacc aaaagtatac ataactgcca aggcatagag attaaagaag ccacctgact   1986180
gcaaggctaa attcttcaga ggaggtagta aggtctctcc taaaacatga gctaggataa   1986240
acttatacaa aaagccccac atgatatagc ggacagattc atccagcata tccatcaact   1986300
catctcgctc aggaatagcc tgataatttt cattaaatcg cttaaagcga tcgattggac   1986360
cactcgagaa agttggcatg aagagaagga aacggaggaa ttcccagagg gtaaaatcct   1986420
taatcactcc atctctcagc tcgatgacaa ttccaaccga acgaaaggtc aggtaagaaa   1986480
ttcccaagaa cccaagcaaa gactgcgttc cattgatagc tggttgcacc ttgacaaaga   1986540
taatcggaag tagggacaga aaactaacta agtagaagac ccacttgcca tccttgcttt   1986600
ttcgataatg cttgtagaaa agcaggagca atatttccca gcaaaggtaa atacccaagg   1986660
cagctagttg attggtcttt ccacccacca acatggtgac aataaagaag agacttacca   1986720
acacttcata ccaggcaaag cgtttcttga aaaagagacc tataaagatg ggcaaggttg   1986780
cagcaatcac ataaacaaaa tactgaggat tgccatatgg ctctaaatga ggaagctgtt   1986840
gaaaaaactc catcatctct tattcacctc gttaatcaat cctttgatgt caatctttcc   1986900
atttggagtt agtggcaaac tgtctcggta aaggaattta gatggcatca tataggacat   1986960
catgatgtct gtcaggtctt ccttgatggc cttggtaata tcgatatctc gctcaaactg   1987020
ctcacgaaca ccgtctttta agatgacata agccaataga ttttgtacct tgtggtcctt   1987080
gttatagcgc ggtactgcga cagcagattc gataaagcga gacttgttga ggttttgaga   1987140
gacatcttct aactcaatgc ggtaaccgtt aaacttaatc tggaagtcca tgcgtccgcc   1987200
gtagagaagc aagccctcat ctgtcatggt tcccacatcg cctgtgtgat aggctggcag   1987260
atcttcaaac tcaaagaagg cttctgctgt tttttcagga ttgttcatat aaccttttga   1987320
aacagctggc ccagaaacaa tgatttctcc ctgctcacca tttggcagtt tatttccttc   1987380
ctcgtcaatg ataaaggttg gagaatcagc cttggtatag ccgattggta ggcgtttgag   1987440
agtcgctaac atctcgtctg tcacggcaac tgctgacaga gctactgtcg cttctgttgg   1987500
gccgtaagca ttgatgatac gggcatttgg gaaacgctcg cgcagttttt gagctgtttt   1987560
gaccgtcaat tcttcaccat caaagtagaa atgcgtgatt ccaggcattt tctcactgtt   1987620
gaagtattca gacaacatgg ccatatctgc aaaggatggt gttgatgtcc agatagcgat   1987680
tggcaatgaa aagatagccg caaagagttg cttaaagtcc tgagtgatga ctgaaggaag   1987740
agtgaaaagc gtaccaccaa gtgccaaggt cggtgcccaa tacatgacag acaagtcaaa   1987800
agaataaggt ggctgtgcca gcatttgcgg acgactcggt gtcgcaaatt ccttatccgt   1987860
aatcatccag tttgtaaagc tgaggagatt atcatgtgaa atctgcactc ccttaggctt   1987920
accagtcgta ccagaagtaa agataatgta gtaattatca tctcccttga ctggatgcgt   1987980
gatttcatag ttattccctt gggcaaaggc ttcttgaacc tgagctagat ttatcattgg   1988040
tgtagaaacc tgctccaagg gaaaggctga aatggcaata atcaagcttg gctctgctac   1988100
ttctaaaata gctgaaactc gctccaaggc cgaatggcta tcaattggaa tgtaggcatg   1988160
acctgactta gtcagcgcta caaaggttgc caacatttca tattcttggc caccaaaaac   1988220
aaccacagga gacttctcag gcaagcctag ttggtcaatg actgcagcca aactatccga   1988280
atcagccttt aaatcgccat aagtgtgttc ctgccccaaa acattataga caggatagct   1988340
aggctgtgtc tgagcaaaat gctcaatggt ttcaatcata tctgctattg gtttatttga   1988400
cacaataggg attctccttc aagttaaaat tcattataga taaagcttcc ttgaccctga   1988460
ccaagatagc taaagaagta aagcagccct agaaagataa gaaaatacaa ggctgtccga   1988520
ccaagaaaga ggtacaattc ttttctctgt ttcatcaaga aaaaccattc atttctgtaa   1988580
tttttcgcta aaataagagt gattcttact agcttatttt tctaccattg taccacttta   1988640
tatagtatct tttcaattgt ttaccgtatg tttccaatag atttcagctt attttaagga   1988700
ttatacagtt tttctatgta tattttcaaa tagagtgatc ctgcttcaaa actccatttc   1988760
aggagacaat gaagtaaatc ttcccataat aaaacacaca atatcaagtt ttttcaacac   1988820
ctgatactat gcgcttttct gatttttaaa gactttttaa ccactctctc atttaaaata   1988880
atctcgtctg atataaatta aaatagcttc tatcatcaga caaatggctg atagccaaaa   1988940
actgatgcta ataccaaaac tctcagtaat atagctcatt agcaaaacaa atactgaaaa   1989000
tgctaatgta gaaatcactt caagaacgga atagacatta actaaatgat tttcctctac   1989060
tgtttcctga agaaatacac tttcaggaac ttcttttagt tgcgataaca taccaactaa   1989120
agctgaaaat aataaaaaca tctgtgcgtt tggaaaatat agaatagtca gtgtcactat   1989180
ttccatagct acaagaggaa aaagaatact ttccccccaa atcattcata cctctctcaa   1989240
ctagatgtaa cttacaaaac ccctgacctc atgagccact ttcttcctcc tcatgaggtc   1989300
agttttactt tctgctgttc cagtatcgtt tttcctcgct agatttcctc aaaagggcag   1989360
actcctccct tggtgcgtca cacgattttt tcatctcgac tgttctttaa tgcatcatta   1989420
acgacgcttt tcttctaggt ggttcataag gaacaggaag attcaggttg acttttctaa   1989480
tcctagaata aagtgctgaa aacaattcgg aataggcata gagactagac aatttgagga   1989540
gctgcttgcg tcctgttcga acacattttc ccaccacgtg aagaaaaaga tggcggaagc   1989600
gtttgattgt taaagtttgg aagtcacctc cagctagatg tttgagaaaa agatagagat   1989660
tgtaggcgat acagctcatc atcatacgaa cttcgttttt gattaaggtt gaactatccg   1989720
ttttatcgcc aaaaaatccc tccttcatct ccttgatgaa attctcggct tgaccacgtc   1989780
cacgataaag ctgaaactgg tcttggcttg ttccactcgt catatttgta acgagagaaa   1989840
taacatcgta gaacaagttt ccttcttttc gttcagagaa ctggcagaca cgacgcttgt   1989900
gcgaccaaga tcctgcttga tagagagttt ctgagtaggc ggagtggggc aagatggtta   1989960
agtcctcatc ctgtgggcaa gggagggaaa ggtctccaag acggctcaga acagtatttt   1990020
tcttgagttt tatgaggtag tattgccctg ttttttcaat taaatcgtat aattttgggg   1990080
tcgcaaagcc actatccatt cgaaagagaa gttgattaaa ccgttctaaa acaggtgtga   1990140
taaagctgtc tgcctcttca gaacaataac gattaccagg acgaagctgg gcattgaaac   1990200
aataacctgt cttcccctcg aaagcataaa gaggatgata gccatgagca cgatagtggg   1990260
cgttataagc aacaccttct tgcttgccat aagttgtgaa atgggtagaa tcgatatcta   1990320
caatgagttg gtttagctgg tgaaactgta aaaagaattc gaccaattca aggttgaggc   1990380
atcgcaaact atggactgtt tcctcgtcag ttctggaaag aaaacgggat aaggttggct   1990440
gtgaagcaag ctgccctcct tccaacaatt ttggaaagta ggcatcagct gacaattctt   1990500
tacaagcata gtccgttcca taacctgtta acagttgaaa gaggaactgg acaaggatat   1990560
ctgaatccga ataacgacag tagcggcgtt ggtcattcgt tactaaatac ttagaaatcc   1990620
gctcttttag tttcaactgg gaaaaaagtt cctgaaaaaa gataagacca ccatactggg   1990680
ttaaatgacc tccatcgaaa gatagttggt aaaaagactt gttttggaag tgatgatttg   1990740
gtaaactgtt catgtgagtt tcctttcttt ttgtgttttt ttctacactt ataccataaa   1990800
ggggaaactc ttttttgtct agtaaaaaac acccattggg tgaaaaaaga aaccatccag   1990860
gatctaagct aaggcaagga ttctggatgg tttttagatt tggggtgaat aattggggtt   1990920
cccatttagc agcaaggaac ttttcagata gcctaaaagc aattaagcca ctaattataa   1990980
taccaataga gtatgctgta ttagaatatc cccagtaact ttccgtttta tttaataact   1991040
ccgttacaaa aacaagtata atggaagaaa cccaaatcgt atttgaaaaa atttccaata   1991100
aatttgctga tacaaaaagt cttaatctag gatttctagc aactaacttc caacctttga   1991160
gcaaaatttc aagattagtt tctgactcta acacctccac ttcagcgtta ggaagaaata   1991220
acatcagaaa gctagaaatg atatacaaga ctaaattgat acacgtggta ggtaacagac   1991280
caattgttgc aaacaagagt ccacctaatc cccaacctat caattgaaca gcttcaccag   1991340
tcattgataa ggctgaatta gccttaccca aatcggtcgc atagcgtggc acaatagcat   1991400
aggaaacggg tgctgcaaaa ccatctagta tggaaattgc aacaacaaat agataggtca   1991460
ccaaaggcgc tacggattgc attacggtaa acattcctac cagtatcgcc aataatatag   1991520
tctttccaaa ttgagataaa gataaaaccc tatttagcgc taacctttta gtaaccaacg   1991580
gaactaaaag actcgcaaca aaagaggata ttcctattaa gataggaact agtgatgtgg   1991640
caattactga ttttgaaata atgtatatgt tagcaatgat tgttactcta aagaaaatat   1991700
ctgctaaatt tgcaaataat tgagagacta acaacttgac aaatgaatta gacatgtagc   1991760
gctccccctt tagttacaaa ctttggaatt aaatttgatt tttaatattt tagcataaaa   1991820
tagcagaaaa caaaagtgag gttttttaca tgaaaaaaca aaaactattg cctttattat   1991880
tcctaatttt aggaggaatt atgattatcg ttgttggcta gtactaagaa gttagttagt   1991940
tagtagaata attacatctt caatcgaaaa agagactgga aaaagtctta aaaatcagaa   1992000
aaacgctcaa atcctttggc gctctaagct tttctaatga tagatttaga tagtcaaaaa   1992060
aatatctgaa aagttcccag gatcgtcgtc tcagcatcaa aaatacgtga aatttgcata   1992120
attaaaataa atttcagggg agttaatcga gtaggggata atctctagcc cctctcacac   1992180
caccgtacgt gccgtttggc atacggcggt tcaactaact tttaacgcat gtcgttcaag   1992240
gtaataatcc aaacacgaaa ccagtccacg tttttccagg actggttttg atatagcacg   1992300
tttaagtacc gacttctgag ctactaattg ataatggtcg ccccagccag ataccttatc   1992360
tgctatccat ttaggaactc ctaacttaag caatccccat aatcgtctcg atttcttctt   1992420
ccattgcttc cagataatca ctcgtaggcg agtacgcaag cgctcatcta tgctggcgac   1992480
tatacttttc atatttccca atgagcaata gtttatccat cctcgaatag acaaattcag   1992540
ttgctcaata cgtcttgtta ggtctatact ccatttcctc tgtgttagtt tcttcaattt   1992600
aaacttaaat ctccgaacac tatcttgatg tggacggctt ttccaaccat ctgataattt   1992660
ccagaaccca aaacctagat atttcaactc tcttggtcat gtttactttc aaacctagcc   1992720
gtttctcaat aaaacgactg actgaataca tcacacgctt agaggctgcc tcgcttccga   1992780
ccgtaatcac acaatcatct gcgtagcgca caaatcgaag tcccctcttt tctaattcct   1992840
tgtccaattc attaagcatg atattggata agagaggaga taaatttcct ccctgtggtg   1992900
taccaactag tgttttataa cgttgaccat taatgataac acctgaatga agatacttac   1992960
gaatcaagga ttccgtatct ccgtcttcga taatgttatg tactaaggac atcaatctat   1993020
cttgaggaac tgtatcgaaa aatttctcta ggtctaatcc actatccact catagccgtc   1993080
atttaagtat tctaagagct tcatgatggc tttttcacat gacctatttg gtctgaaacc   1993140
ataactcgta tctgagaaat ggggttcaca aatggggctc atgacttgga caatggcctg   1993200
ttgaatcatt ctatccataa ctgttggaat tcctagttga cggatgcctc cgtctggttt   1993260
aggtatctca actctaagaa ctggttgagg cttatatttt ctctgtttta tcagttcctt   1993320
agtcaagcgc cagttttgtc tgagataatt atccatctct tcgatagtca ttccatcaat   1993380
cccagctgag cctttattgg attttacttg attgtaggct tccagcatat tttcgcgtga   1993440
taatatctta tctagcagtt ttgacatgtg cgtattcctt tcttattttg gtgcctgagg   1993500
gacatcttat attggtgaac cttcatctag tcattacgtg tcaaagtcca gttctatcag   1993560
accactcatt ttacagacac aagtgaagta ggattacttc gatctgtcgt tttctctttc   1993620
tagcgacaga cctcaaacag tctctcccca gactgtttga gtattcaccc cttcgctcca   1993680
cttccattac ggaagtttcc tcactactat gggctcggct gacttctcat gattcgttgt   1993740
tactacgctt tcagcgctca tgaaacctca cgggataagt cgtacatctt tcctcgttta   1993800
tacaagatat gaggacgtta aaaggttaca gtgaaaatag gaaatctgac gcagagtctt   1993860
tagactctag aaagatttat ctttttcaca caaaccttag tccgaattca attactctcg   1993920
tgatttacac atataggtta cgactacctt tttggacttt agagtttgaa gcctccttat   1993980
ccgctatata cgccttacta tcacgttcct gttcgtagag ccacgatttc gctatccctt   1994040
cctctccctg ctacctcacg atagtcaggc tgaggactta cacctcagat atacgacatg   1994100
cccgtcgtac tacaaaaaaa cgacgattta aatcgtcgtt ttgctaatat aaatatgcat   1994160
tttttttttt tttgaaaata cgtctattta ttttttattg ttttttattg tagagcagac   1994220
ccaagcgaat gaacataggt tgtaaaaagc aaatgaaaaa actgcgagga taatagcttc   1994280
tgtgtctaaa taacccattt cgagacctct tttcaacaac aacaagcctg tagtttcgat   1994340
aacgatcaaa cataaaaata tataaaaaat tttcgcatta agcatattgt taccgctttc   1994400
tttttatttg gttttattgt ataataaaag ttgaaaaaaa tcaaaaatac aaaggagttt   1994460
ccgttatgtc taagatgttt aaatgcatgt gtttgctagt tatgtctgtt ttctgtatgt   1994520
ctagcatttc cccgtcgctt gtttgttttt gctgatgata gcttatcggc aaactctaaa   1994580
gttgtatctg gtgaggctca gtttgagaat ggctcatcag tgcggttcgg agatacgcaa   1994640
gtaaatattt taagcgatga agttcttgag gttgtcaatc cagatggaag tgtagacact   1994700
attgaacgac gtgctgacgg cgtctatatc aatggggcat tttatatggc ttatcaaaag   1994760
aatgaaatcg acctaaatat atcttttaga tcatacgatc ctaatgtttg gaattacgtc   1994820
aacacaatac atgggaataa acaagctaac acattcgcta acttcatgac tggtgctgga   1994880
atcagttata tgattggtag gataggtgct ttattggggg gtccatgggg tgcaataatt   1994940
ggtggagcat attttggtat acaagcttat cagtcttact tggattcaca aagcccatat   1995000
ccatactaca taacaagtac ttatatccat gttgctcaaa gaaaatggaa gtttatcact   1995060
gaatactata gaaactcaaa ctatactggg tatgtaaaaa ccgtaacaac ctacgtgaat   1995120
ttctaaaata taaaccctgc ctagatataa aggcagggtt tatattttag ttaattgctc   1995180
aagtaatttg taagcataat acttgcgaaa ctctatttgt tcaagcggtt caaaagctct   1995240
tgttttttac cctcaagctc agctctcctt tgctcgattt cttcacgttt ttgggcgatt   1995300
tctgcttgcg cctcgggagt ttccaaagtg ccttgtgact tgtgaaattc tactagcata   1995360
tcaacgattt ttgggtctaa ttcgttgaca taatcaggat ttgaccattt cggcacgttg   1995420
cttgcaggtg cttgcttttt gccgcctttt ttgggcgttt tggcttgttg ttcagctttc   1995480
tgactgtagt tgacctcgtg gaattttcgt gcttgatatg atgcgtttta ttatgagaag   1995540
atttacttca ttttttgctg aaattgggct cttgcccaag ctctatcaac ataattgttt   1995600
tctaatactc aatgaaaatc aaagagcaaa ctaggaagct agccgcaagc tgtacttgag   1995660
tacggtaagg cgacgctgac gtggtttgaa tttgattttc gaagagtata aactagaaaa   1995720
gtgagaatac aagcactgcc aaggctgctc cgataacagg gcctacaaca ggaatccaag   1995780
cgtaagacca gtctccgtct cccttgtttg gaattggcaa gatgctgtgc atgatacgag   1995840
gtccaaggtc acgagctggg ttcaaggcat aacctgttgt cccacctagt gatagaccga   1995900
taccgacaat caaagttccc actgcaaagg ttccgatacc tgcctgaaag tcgtaaagac   1995960
ccaaagcaaa gattgtcaac accaaaacaa aagttccaag gatttcgcta atcaagtttg   1996020
atacagtatc cttgatggct ggtccagtac tgaaggttgc caggatattg cctgcatttt   1996080
cttctgcctc atagtgaggt ttgaattgca accaaaccaa aatctgaccc agcatggccc   1996140
ctgcgaactg ggctaagata taaggcaaaa cggaagccca aggcaaacca ccttttaagg   1996200
ccacaccgat ggtcacagct gggtttaaat aagctggact gagcttgcca gatacaaaga   1996260
ctgcaaccgc aactgcaatc ccccaaccca tagtaatcac aatccaacct gagctattgc   1996320
tcttggtttt aggaagaacc acacctgcaa caacaccatt tcctagaaga atcaggatta   1996380
aagtccctag aaattctcca aataattcat tcatcatctt tctgtctcca ttaaaaagaa   1996440
gggacgggcg acaaggaatg ctgccctcca cctcttttat tttttcttaa ttttttaatt   1996500
ctgctaaatc gttgttagcg agagctgctt cgacatcagc acggtaagtt gctttttctt   1996560
cttctgtcca gtcatagaat cgtcccattt catccaaaat tggctcaacg atactatcca   1996620
agctatcacg cataaagagc atgtgattgg tacgacgaag aaggaagtca actgggctaa   1996680
gagtcaactc attgcgcatt gcatagtgaa gggacaaagt atctgccaag ctgagtcctg   1996740
gcgcttgttc caagctgtga gcaagtgcaa agactttcgg tgcatttgaa ccgtaaagat   1996800
ttgccagata gtgagcttcc ttgctatcca aaccacgtga tactccaagt tgcgcaaagg   1996860
cttcgatttc tgaatccaca tttgctgggt tcaattctcc acctgaaaca gggtaagttt   1996920
tagaattgat caatttaaag ctacggtcaa attctgcttt gaggatgtca accacgcgct   1996980
ccatagctcc ttcagccatc ttacggtagt ctgtgatttt accaccagca agagtcaaga   1997040
gaccattgtc atcacggtcc aagctagacc cacgagaaac tgcagatgga tccaaatgtt   1997100
tctcagatgt gctactttca agcttgctga cagcagactc aacatcttca cgtgtttttt   1997160
ctttggagag ataagattca acagtcgcaa tcaagttgtc aaagctttca tcactgatgg   1997220
taccgttatt tccaccatta tagtcagagg cactgttccc tgcaatcaat ggacgaagac   1997280
ctgcccagct gctttcgata tcatcaatgg tgatgttgga ttctgggaag cggttgttga   1997340
caatgccaag tagataatct acatcttctt gagttacttt tggatgctcc aaatcacctg   1997400
tgtagtctgt atcagttgta ccaaagtaag tcttgttttc acgtgggaga acaaagacca   1997460
tacgaccgtc acccaaacct gtgtcgaagt aaactggctg tgaaaccttg attttgcttg   1997520
aatctactac caagtgaact cccttagttg ggcgcatttg tgagaattgc gttcccttat   1997580
tagacaaatt acgtacttta tcactccaag gacctgttgt attaataacc agacgggcct   1997640
tgatttcaaa cacttggtct gtcaagagat cacgagctac aacacctgta atcttgccac   1997700
tttcgtcaaa gaggaagcct tctgccttca cgtggttggc aatgagggca ccgtcttggt   1997760
tggcacgttt gatgttttca atcacgagac gcgcatcgtt gttacggaag tcaagataca   1997820
ctccacctcc taccaagcct tccttcttca agtttggctg gcgttccaag acttgatcct   1997880
tgctcaaaac cttgttcgca gctggtgtgt tgctaacacc tgccaagagg tcgtacaagt   1997940
ccatggctac tttaagacgg aagaggctaa aggttgctcc atcttcatcg taaactggta   1998000
agagcattgg atctgatttt ggaatgtgtg gagcgatttg ttgaaccact gcacgttcag   1998060
aaaccgtatc tgagaccact tctacgtcaa attgtttgag gtaacgaagt cctccgtgaa   1998120
ccaattttgt tgaacgacta gatgttcctt ctgcaaagtc ttgcatttca atcaaaccag   1998180
tctcaagacc gctagctgcc gcctgcaagg ctacaccagc tcctgtgatt cctccaccga   1998240
taatcaagag gtccagggta cgttcctgca tttttttaat tgacaattca cgtgttttct   1998300
ttgaaaattc catatttaca cactttctaa ataaatcgct ttattctgcc agtattagtc   1998360
gtctacttcc gcaaagactt gagttgcttt cacagccttc ttccagccct tgtagagttg   1998420
ttccttgcga gattcgttca tagatggctc aaagagttct cctgtctcgt tcaagagttt   1998480
caactcgtcc aagtctttcc agtaccctac tgacaaacct gctaggaagg ccgctcctag   1998540
agctgttgtt tccaggtttt tagcacgtgc aatgtcaatg cctaaaatat ccgcctggaa   1998600
ctgcatgagg aagttgttca tggctgcacc accatccacc ttcagtactt gaatggcggt   1998660
ctgagtatcc acttgcatgg tgtcgatgat atcacgcact tgataagcaa tagattgcaa   1998720
agtcgccttg ataaagtctt ctttgcttgt tccacgagtc aaaccaaaga cggaaccacg   1998780
agcattttgg ttccagtatg gagcgcctag acctgtaaag gctggaacga cataaacttc   1998840
atcgttgttg tgagaatcac gagcgtattt ttcagattct ggtgaatttt caaccatgcg   1998900
aagaccgtca cgaagccact gaatagcact tcctgcgatg aagatagaac cttccaaggc   1998960
ataataaacc ttaccgttga ttccgtaacc aatggttgtc aagaggttgt tttcagacaa   1999020
ctgcatctct tccccagtat tcatgatgat gaaagagcct gttccataag tattcttaac   1999080
catacctggc tcaaaagcca actgtccaaa gagggctgct tgttggtccc cagccatacc   1999140
tgagattggc acctctccac cgtagaaatg gaatggagct gtcttgccgt agatttcgga   1999200
gttagaacga acttctggaa gtatagcctt cggaatgtta aggatttcca aaatctcatc   1999260
atcccatttg agttctttaa tgttataaag catggtacga gctgcatttg agtagtcagt   1999320
cacgtgagcc gcaccgtcag tcaatttcca aaccaaccaa gtatcgatag taccaaagag   1999380
caattcccct ttttctgctc gctcttgagc accttctaca tgatccaaaa tccaacgaac   1999440
cttggtagca gagaagtaag catcaataat caaaccagtc ttttcatgga atttttccac   1999500
ataaccttgg ctttttagtt gctcagccaa aggtgctgtc tggcgtgact gccaaacgat   1999560
agcattgtag ataggaagtc ctgttttctt atcccagaca accgttgttt cacgttggtt   1999620
ggtaatcccg attgcctcga tttgatttgg cttgacacca ctttcgatga aagcacccgc   1999680
aataactgac tgaacagagt tccaaatttc attggcattg tgctcaaccc aacctgcctg   1999740
agggaaaatc tgggtaaact ctttttgact cgagctaacc ttttcccctt ttttgttgaa   1999800
aatgatggca cgagaacttg tagttccctg gtcaatggcc atgatgtatt tttcttgtga   1999860
catgtactgt cctcctgata aagatcttga ggtgtttcct ctttacactt actagtatac   1999920
aaaataaagc gctttcttgt ttatcaactt tttttaattt ttaaaaaaat gtgaggagat   1999980
tgtgtgaatt tcacaaaaaa gacctggatt aaccaagcct tttaagtgaa taataactgg   2000040
cgaatcgcta ccaaatcctc catatccaag tcatttttta aataatagac tggtgtctgt   2000100
tccttcttat gaatcgggtt attggtaacc agcaaatcat aatgccgact agggtcataa   2000160
gcttcaatgg taataaaacg attgtattcc aaataccgtt tcaaaatggc tgccatcctt   2000220
gaaaagacaa gaaaaccaga tgtcaaatcc agaccaatcc gcatatgctg gccaccgttt   2000280
tcagccatat attcgattaa ctggagccat tcccagagaa tcttcttatc taaatctgtc   2000340
ccctgttgaa aagcaggtag agcatgaaaa atctcctctg ctgtctcttt aaaatcatgt   2000400
tccatcagta aatatggatg acgattctct aactggtact tgtagcgatc ctgtaaaata   2000460
tagcccttat agagatagac ttgagcacaa agctgactga gttcataggt gacatggtcc   2000520
tctgtataat cccccaatag ttcctccttc ttcatttctt gaatcaattg cgtcagtaaa   2000580
tctgccaact gccctccaaa accaagaata tactccatag tatgaagagg aagaatgcga   2000640
tgagatagga gaaaagagaa gaatatcatc atctcaccat cctcaactcc tagtggaata   2000700
tgttgcccag caaaaaagga cggaaccttt ctcagcaaac gaagataaaa gatattgtca   2000760
aaataccctc gcattttctc ttctatgact tgaaactgac aagcattgac ccgaagacgt   2000820
tgttgactga tgtgagccca gagaaccaag tccaatttct gccccgcaga caaacttgca   2000880
ccgcagattt cctctaaatt ggcaatctcc tgttttctct ctggtttctg catgtgacct   2000940
tcccattcct gactcgacca gacctttcgg aaaagacaga aatagaaata gtgaatctga   2001000
tgctctggac ctcgccaacg gccattttgg atggataaat caaattctga caaaatctga   2001060
tttaaaccag ccaagtgacg accaagcgta gcctcgctaa tcaccaattc ttgagccagc   2001120
tgatgggcta aaaactgttg gtggtagaga agataaacca aaatctggta tttaacagca   2001180
ctctccaaaa acaagctccg aatatctctc cccttggtag ctgcaccgat agacagacgc   2001240
agattttcat cttctgagtg aatagccagc tctaagccac tatccaaagc cttgtcattg   2001300
agcagggtga catatttggt tagggttgct tttgaaaatc ctgtttcttc cattacagcc   2001360
ttgacggtcg tctgagactc ttgtaataga aaggaaagta ttgaaaattg accacactcg   2001420
gctttctcca tcaaatctcc taaatacatt tgttatccct ttcattttct accttaagca   2001480
tagcataaat ctgacaaatg ctaaaataat ctgtttctct ttttattttc atgctgattt   2001540
cctggtccat tatcctgaaa atcagtaaac acacggctcc ccctttgggc atttttatgc   2001600
taaaatagta gctatggata aaattattaa aactatatca gaaagcggag cctttcgtgc   2001660
ttttgtcctt gatagcactg aaaccgtccg cactgctcaa gaaaaacatc aaacccaagc   2001720
tagctcaact gtagcgcttg gtcgaactct tatcgctagc cagattctcg cagccaatga   2001780
aaaaggaaat accaaactta cagttaaggt gttgggatct agctctctag gtgctattat   2001840
caccgtcgct gataccaagg ggaacgtcaa aggctatgtt caaaatcctg gtgttgacat   2001900
caaaaagact gcgactggtg aagtcctagt cggacctttt gttggaaatg gtcaattcct   2001960
cgttatcaca gactacggta ctggaaatcc ttacaactct ataactcccc tcatctctgg   2002020
agaaatcggt gaagaccttg ccttttacct tactgaaagc caacaaacgc cttcagcggt   2002080
cggcctcaat gtccttttgg acgaggaaga caaggtcaag gttgcaggtg gtttcctagt   2002140
tcaagtcttg ccaggagcca agaaagaaga gattgctcgc tttgaaaaac gcatccaaga   2002200
aatgccagct atctctactc ttctcgaaag cgacgaccat atcgaagccc tcctcaaggc   2002260
tatctacggg gacgaagcct acaagcgtct ttctgaagaa gaaatccgtt tccaatgtga   2002320
ctgtagccat gaacgcttta tgaacgctct tgccagcctt ccaagctcag acttacagga   2002380
aatgaaagag gaagaccacg gggcagaaat cacttgtcaa ttctgccaaa ctacttacaa   2002440
ctttgatgaa aaggacctgg aggaactcat tcgtgacaaa tcttaataca ccttttatga   2002500
ttggcaatat tgagattccc aatcgtaccg ttttagcgcc tatggctggc gtgaccaact   2002560
cagcctttcg tactatcgca aaggagctcg gagctggact cgttgtaatg gaaatggtct   2002620
ctgacaaggg aatccaatac aacaacgaaa aaaccctgca catgcttcat atcgatgagg   2002680
gcgaaaaccc tgtctctatc caactttttg gtagcgatga agacagccta gcacgcgcag   2002740
cagaattcat ccaagaaaac accaagaccg atatcgtcga tatcaacatg ggctgccctg   2002800
tcaacaaaat cgtgaagaac gaagctggtg ctatgtggct caaggatcca gacaagattt   2002860
actccatcat caacaaggtc cagtctgtcc ttgatatccc acttactgtc aaaatgcgta   2002920
ccggctgggc ggacccatct cttgcagtag aaaatgctct cgctgctgaa gctgcaggtg   2002980
tttctgccct cgccatgcat ggccgtaccc gtgaacaaat gtatactggc cacgcagacc   2003040
ttgagaccct ttacaaggtt gcccaagctc taaccaagat tccattcatc gccaacggtg   2003100
atatccgtac tgtccaagaa gccaagcaac gcatcgaaga agttggtgct gacgcagtca   2003160
tgattggccg agctgccatg ggaaatcctt acctcttcaa ccaaatcaac cattactttg   2003220
aaacaggaga aatcctacct gatttgacct ttgaagacaa gatgaagatc gcctacgaac   2003280
acttgaaacg attgattaac ctcaaaggag aaaacgtcgc agttcgtgaa ttccgcggtc   2003340
tcgctcctca ctatctccgt ggaacatctg gcgctgccaa actccgtgga gccatttcgc   2003400
aagccagcac cctggcagag attgaaaccc tcttgcaatt ggagaaggct taatagttta   2003460
aaacccgtaa ctctcttaaa gagcctcttg aatgccgcca ttctttcctc atcaaaaaaa   2003520
ctccgtagtc tctagcgcta taaatccggc tagagattac agagttattt tttaatctaa   2003580
acttcctaca agggtatatt atctactgaa aggatatggt atttgtaggg aatactttaa   2003640
agagttctta caggaagtca gtattaacta gttatattag gtttagttta cccattcacc   2003700
attggcattg actccatagc catctacagt tgtgttgact gcaagggcac ctgagccatt   2003760
gacatagtac catttatctg atactttgaa ccattggctt gctttcatag cacctgatgc   2003820
ttcaagatag taccaggtat ctccatcttt cacccaacct gtcgccatat caccattagc   2003880
gtttaggtag taccatgagc cattgtattg gagccatcct gtcgccattg aaccattagc   2003940
gtttaggtag taccatgagc cattgtattg gagccatcct gtcgccattg aaccattagc   2004000
gtttaggtag taccatgaac cattgttttg gagccatcct gttgccattg aaccattagc   2004060
gtttagatag taccatgaac cattgttttg gagccatcct gtcgccatag cgccattgct   2004120
gttgaggtag taccatgagc cattgttttg gagccatcct gtcgccattg aaccatcagt   2004180
attgtagaag taccacatac cgttttcttg tttccagcct gtttttggag tagatggttg   2004240
tgctggtttt tcagtttttg gcggttgctg ttgagtcaag cgattatatt cttcttctga   2004300
tctacgagca tagtcttctt cagcttgttg atcagctggt ttttctgctt ttggttgttc   2004360
agctggattc tctggttttg gagctggagc tggtttttct gcttttggag ccggcgctgg   2004420
ttgtggttgt tcagctggtt tttctttaac tttatcttct tctgctgctt ttcgtttagc   2004480
ttcttcttct gcttttttac gatctgtctt gattttttct aaccttgtag cctcagcttt   2004540
tttactctca acttccgctt ttgcttgctt aactttttcc tcgtttcgag gttccttagc   2004600
ttcctctttt actagttcaa gctccgcttt tttaacttcc acatcggact cagcaatttc   2004660
aagttcaagc gttttgtaag tattggttgg gtagttacgg cgatcttctt ctttttgatc   2004720
ctcggctttt ttcttagctt cttcaacctt cttctcagct tctgctacct ttttttctgg   2004780
tttcagggat gggcttggaa gagtttcttc acctacgcta gaatctgaag acttcgcatc   2004840
attttctttt ttatcaggtg ttgctagctc tccaggaact cctcgttttg cccgcccctt   2004900
tggtttacct tgctctttag catctgctct tcgtttagct tcttcttctg cttcttcacg   2004960
atctgtcttg atttttttta accttgtagc ctcagcttgt ttactctcaa cttccgcttc   2005020
tgcttgctta attttttgct cgtctcgagg ttcgttagct ttcactttta ctagttcaag   2005080
ctccgctttt ttaacttcca catcggactc agcaatttca agttcaagcg ttttgtaagt   2005140
aatggttggg tagttacgac gatcttcttc tttttgatcc ttggcttttt tctcagcttc   2005200
ttcaaccttc ttcttagctt ctgctacctt ttctcctggt tctgtcggct tgtttggctt   2005260
cgctgtatct gaagcttccg gtttagtgga agagtctgaa cttgacgaag aagatgagtc   2005320
cttttcaaac ttagacacag cttcatctac ttttgatcga ctctccatca tcagtatctg   2005380
tagttggctt tctgaggttg attcaactat tttattcaaa tactcgttct taatgttgtt   2005440
caactcgtta actagagcta cagtaattgt atgtcgcttt ttagttgatt ttgcatagct   2005500
ctcacccact atttttttta catattcctc gacctctttc cttgccttat ctcgttctga   2005560
atcgagtttt ttaggttgtt ctccttgttc tgcctgactt tcatttgccc tattagaaga   2005620
agtgggtact tgggtagctc cctcgttctc tgtcgcatga accacacttc ccataacaag   2005680
actggcaaca actacactag ctactccaac actaaattta cgaattgaat aatgtacttt   2005740
tctttcgctt tttgatgcaa acatgtttat ttccttctat attttttctt taaccttact   2005800
atatcacttc aatatgaact gtatataaat cgaattttgt atttatctct ttatgcttcc   2005860
atttgggatt ataacttcat gtaatagctt ttcctcttca gctattcgtc gatacaaaat   2005920
aactgcataa actggaaaaa ctaaaacaaa agtcacataa gcatgactca acaaggtcaa   2005980
gccaatcaac tcaggaagaa tatttaaaaa gtaattaggg tgttttactg tcctaaacaa   2006040
gatatgatct acatatttgt gattattgac aagcataagc ttcactgtcc aaatatctcc   2006100
caacaagtga atcaccaaca tcaacatcag catagaaaaa ataagcaaga ctaaaccaac   2006160
catgcccatg ccatcaaaaa ttgtcttgtg caccattgcc tcaaccaagc aagagagata   2006220
aaaaacaata tgagccatag ttaatcgttt tgtattctca actccaaatt ctttcccgcc   2006280
attgctaagg attcgtttct cattctctat cgaacgcttt aaaaaaatca atcgaataaa   2006340
gaatgttact aaaataatcg ctaataccat attagtatcc tttcttttat ctacacaaag   2006400
aataacacac ttatgttaac cctatatgaa ctttaataaa aaactaatct gtctacaagc   2006460
taatcttaaa ttccataccg tgttcataag ggagaaaact ataatccatt tgatagcttt   2006520
ctaaaatatt attcacaatg taaagaccca aaccggaact ttcatcctta tctgtcacga   2006580
tttgagaatg atagaatata tcaaataaat gttctagttc ttggtcactt agaggcgcac   2006640
atgtattttt gatagagaga tagccatctt gctcggatat gattacacgc ccatttttat   2006700
ctgaatattt aattgcatta ctaatcaggt ttgtcaaaac cttatccaat gccctaagac   2006760
tcatgacgac cctggtagca tctgtcaatt gattttcaat tgtaacacct attgaatgag   2006820
ctaattcttg ataacgtgat aaaatatcta ctaaaactgg cttaacagtc aaggtctcac   2006880
gacactctgt ccactcttgg aatttagaag actccagtac ttcttctaat aagtggctca   2006940
tctggtcaat cttatttata ctctttgcaa tatattttgg atgatctttg taatctccaa   2007000
tattatgctg catattctct aggataattc taagactggc taaaggggtt ttcaactcat   2007060
gtgatgctcc gcggacaaag gaaacctttt gattttgcaa ttttacaatt tgctcattac   2007120
gactttccaa ctcataaata accttcaaca agtgctcata cataccatta atctgttttc   2007180
caacttcacc aacttcatct ttcctacttt catcaaaacg aatattgtca tccaaatctt   2007240
gcattttact agtcacttct gaaatgtaaa aaagaggatt gagcaagcgt ttagtataaa   2007300
aataagaaaa aacaaaggaa aaagcaattg taaccaaaaa tgtatatggg agatacaaaa   2007360
gcaaaatatt ctttgcttct ttgtagacat ccaccccgtg aacaaattgc acggttacct   2007420
gtttaccatc tgctgtacta acagacatat ctaacatcac gatataattt gatagctttc   2007480
catctttaat atccaagtca tgcacaagag ggagccgctt atctacaata tctcttttaa   2007540
ggtgagcaga tatggtcaag gactttgaat aagactggag taagcttgga atttcatcag   2007600
atgtcttagt ctttaaatac tccgtaaaca ctcttgcgct ctcattaaac ttttccccct   2007660
ccagttgaat ataataaaaa ggaaaggtca aataaatagc tatatgaatg actagaccaa   2007720
caccacctag aattgcaaaa cttcttaaaa aagacttggt taataattta ggatttttta   2007780
tcataagcta atcttatacc caacattttt cacagtcacg atacaatcta aagctaattt   2007840
tttgcgaaga gtacgaatat agacatcaac gaccctatca caaggtaaat cagctacatc   2007900
ttttgaaatt tcttccaata tctgctctct acttaaaact tgatttttat gctgaatcaa   2007960
acactttagt accagtaatt cctttggttt gagatcaatt tcttcatttt tataatgtgc   2008020
tttgtaagag gtaaaatcca ctgttacatc ctgatatcgc caaagatcct ctatgacgta   2008080
gtaacgtctg ataagcgcct taatacgctt gacaagcagt accaaagaaa aaggttttgt   2008140
cacatgatca tcagcataga gatcaaatac ctgtgactga gtagtttcat ctcccagagc   2008200
actcaagacg atgacaggaa tatcgtgctt ttgattgatt tcttttaaca cttcaaaacc   2008260
actcttccta ggcatcatta aatccagtac catgagatgg atagggagat cttgaaattt   2008320
ttccaagacc tcttgtccat ccttagccat aatgacatga taaccctctt ctgtcagaaa   2008380
tgctgcaatt ccttctctaa tcatttcctc gtcatctgca actaaaatgt tcatctctct   2008440
ccctttctac taccagaact ccatacatct atttcctgta tgctatttga aaatttccta   2008500
ccagcctatc atctatgata atggaatgga tttcatttat ccgctacttt ttgtcaacaa   2008560
caacgtcaat acaagaaaat cattcatctt gcagcttata ctcttcgaaa atctcttcaa   2008620
accacgtcag ctctatctac aacctcaaaa cagtgttttg agcaacctgc ggctagcttc   2008680
ctagtttgtt ctttgatttt cattgaatat tagtttgatt tttcaaatac cagctagaac   2008740
ggatttgaca tgcaaaaaag aaacaggtct cttttgaaag aataaaaatt tcagataaga   2008800
ctgctctttt tctactacac acgctctaag acaaatacga cggagggtaa taaacatatg   2008860
aattttgtgt tgaatgatga aaaccacgga tcgtttagaa gctataggtt ttagtttcat   2008920
actcttcgaa aatctcttca aaccacgtca gctctatctg caacctcaaa ccagtgtttt   2008980
gagcaacctg cggctagctg cctagtttgc tctttgattt tcattgaatt tcactccact   2009040
gtgacttatg gtcagatgct gatactttta ttcttttatg caatatcaaa ttttaactgg   2009100
cctgctttga caccaatctt aagtgtgctg cctgccacta aatctccctt gagaagaagt   2009160
tctgccaact tgtcctccac ttctgtttgc agggttctgc gaagtgggcg agctcccatc   2009220
tctgggtcat atccttgatt tgctaacaat ttcagagctg aagcttgtaa tttcaagtca   2009280
atgccttttt cagtcaaact tgccactaaa ggcttgacca taatcttcac cacttcctgc   2009340
atatgatcac tagataggct atggaagacc accttctcat caatacggtt gatgaattcc   2009400
ggtctataag cttttttcag ttcttcaaac atgcgttttt ccatattttc ctggtcaaaa   2009460
cgaatatcct tagccccaaa accaacagtc ttatcatcac gaagggcagt cgcacctaga   2009520
ttcgatgtca taatgataat ggtatttgaa aaatcgacct tgcgtccctt gctatctgtc   2009580
aagacaccgt catccagaac ctgcaagaga acattaaaga tatctgggtg ggccttctct   2009640
acctcatcaa agaggagaac ggaatagggt ttattgcgaa ccttctctgt caactcccca   2009700
ccttcttcat atcctacata gcctggagga gctccgttga gacgactagc tgcaaatttc   2009760
tccatatact cactcatatc aaagcggata agggctgatt cgtcgtcaaa aagaacttct   2009820
gccagagcct tggctaattc agttttcccg acacctgtag gccctaggaa cataaaggaa   2009880
ccaatcggac gcttatgact gcgaatccct gactggttgc ggcgaatggc acggctaatg   2009940
cttgaaacag cttgatcttg accgataacc cgtttatgga gttctgcttc aagatttaaa   2010000
tacttcttag catccgtttg agtcagtttt tgaactggga ttcctgacaa gcgactcaag   2010060
gtggtcaaaa tatcagactc tgtcaccaag tctttgtaga caggtacttc ctcttctttt   2010120
gcgattagct gggctgcctg tttccacttg ccatccatca gggccttgtc agctggactc   2010180
aaatctgaat cgtctgcttt tacatgcttt gccttatttt gcactgttgc tgccgcctca   2010240
tccaagagat cgatagcaga gtctggcaag tgacgactgg ttaaataacg atgagccatc   2010300
ttaaccgctg tttcaaccgc ttcatctgtg atttgtacac ggtgatgttt ctcataagtc   2010360
gccttcaaac cttgtaaaat agtcatacta tctgccacac ttggttcttc aatcgtcact   2010420
ttagcgaaac gacgagaaag tgccgcatct ttttcgatat gtttttgata ttcttcctga   2010480
gtagtggcac caaccgttct caaagttcca cgcgccaagg ctggtttcaa gatattggcc   2010540
gcatccagag tcgaatcaat cccgctacca gaacccatga tggtgtggag ttcatcgata   2010600
aagaggatga cttggccatc ttcttcaata tccttgatga tattattcat gcgttcttca   2010660
aagtcaccac ggaagcgtgt ccctgcaacg acattcatca aatcaagttc taacacgcgc   2010720
atcttagcca tttccgcagg cacgtcacca ctagcaatac gctgggcaag accaagcgcc   2010780
agagctgttt tcccgacacc agcatcccca accaagacag ggttgttctt agtcttccgg   2010840
ctcaagattt gaatcatacg tgagatttcc ttgtcccgac cgatgactgg ttctaacttg   2010900
ccagaacgcg cttgctctgt caaatcatgc gtataatcct cgagaccacc actaggagtc   2010960
tgcggcatgc ccatcatatt ggccatagaa ttttgcttgt cagctactgt acgatggcgt   2011020
tggcgtaaag ccttgagatc ttcacgagtc cagcctgccc gttcttctaa atttcgacga   2011080
agagcagcaa tcttgacctg atctttcttg tcttcataag aaaaaccagc cctctccaag   2011140
atacgagtcg ccaaggcatt gctatcatgc aaaatcgcat agaggacgtg ctctgtccct   2011200
agtaccttag catggaccac tgacgctaca tactctgctt catcaaaaag aacctgcaaa   2011260
cgacgggaga acggcaattc cgtaaaggtt tcatcctggc tatagtccgt ttcagtcagt   2011320
tccaaagcca cctcttctaa acggtccatc tcatacggat aatcatttaa agttgcccct   2011380
gctacactat aactgtgatt agacatggca atcaacaagt gccacgactc tagataacga   2011440
gctccaaaat gtccagcaac catgtaggca ctttcgatac attcattcaa tgcttttgaa   2011500
tagttcatct tacttccctt ttctatctac ctcttgtatg atctgacgta gcatgtttgc   2011560
tcgaacaact ggagcttctt ctcctaaaac gcgatccaaa gctactgatt ctagcaaatt   2011620
catctcctgc ttggtcatca attcctgctc aaccaaaagc tggagaatat cctcataaat   2011680
ttcttgactg actcgctcac caatcgagta aagcagctcc cggagcattt catgatgact   2011740
agaaaactca atccgtccta tacgaatgta gcctccgcca ccacgcttac tttcaaccaa   2011800
gtagcctcta ctttccgtaa agcgtgtctt gatcacgtag ttaatctgac taggaacaac   2011860
ctgaaaggta tctgccaact gactccgttg caactccacg ataccagatt gatctaaaat   2011920
cgccttgatg taggcctcaa tatgatccga tgtattttta aatctcataa caaacccacc   2011980
tctctcttta aaccttgacc ttgtttgact attataccga aattttctca tttttaaaag   2012040
aaaaagggcg ctggtaaagg ataatcttca ccaactccct atttttctac ttatctaagc   2012100
ctaattccgc caaaatttga cgtttgtagg caatcttttg gacttccttg tcctcatctt   2012160
cagaccaatc tagtttaatt tctgaaacaa tctgcccagg gcgatttttc aagatataga   2012220
tacggtcgct gagattgagg gcctcctcaa tactatgcgt gatgatcagg gttgttagct   2012280
gcaactgctt gtgaatctca agataccaag cgtggagttc catctttgtc atctcatcca   2012340
aggcgctaaa ggcctcatct aagagaaaga gcttgtgccc aaaaaggtag gtccggagta   2012400
aggctacacg ctggcgcatc ccaccgctaa gttcatgagg atacttgtct cttacagctg   2012460
tcagctggaa ggtcgcaaga attttatccg ctcgggaaat agcttctgcc ttatccacct   2012520
tttgaatcaa gaggggcaga atgatatttc caagcaccgt cttgtgctcc aagagcagat   2012580
ccttttgcaa catataactc acgcgcccct tgggattttc ttcaccatca aggacaattc   2012640
tccctgactg aacttctaaa atcccagcga ttagattaaa gagggtggtc tttccaacac   2012700
cacttgggcc taggatggaa accacttcgc ctgaagtcac ctgtaggttg atatcctcta   2012760
aaatcctctc ctgaccatag gcataactga cgtgctctag tctaatttct gtcattattt   2012820
cacaaattcg ttggtgaagc ctttgtctgt caagtcttct ttaaggatac cattttcttt   2012880
atcccatttg tagaaagcat tccagcgagc tgcgtcaaat tgaccccatt tttccttgtc   2012940
gcttgcgtat tcttttgaca agtatttttg agattcgatg acaaagtcac gtttttcctt   2013000
gagttcaggt gcattcttga tgagaatatc tgcagcttct tctggatgtt ccatggcata   2013060
ttggtagcct tttttgatgg cttggatgac tttgcgagct tcttctttgt tatctttcag   2013120
atagtcgttg tttgcgatga taactggtga atagtagtca aactccttga catagtcttt   2013180
caagtacatg aagttagcat ctacaccttg agatttagca aggataccat cccaaccgta   2013240
gtaaatccaa gcagtatcaa agacgccatt ggcaatcggt gtgattgagt ttgagtcgtt   2013300
atttggtact ttttcaacct tctcaaagtc tccaccttga gattctacca aggttttcaa   2013360
catagcaagt tcagttgggt cattccatgt cccatatttc ttaccaacca agtcttttgg   2013420
actgcttaca ttatcagatt tacgagagat gattcctgat gtattgtgtt caacaatagc   2013480
tgcaacggca gtgattcctg ctcctttttc caatttctta gccatgtagt cttggaaata   2013540
cactgcaaat ggtgcctttc cgttgataac caagtcagaa gaactttctt ctggtggcaa   2013600
tttcaaatca acatccactc cagcttcttt gaaataacct ttttccttgg caacataaag   2013660
ccctgtgtgg ttggtatttg gtgtccagtc taggataaag tcaaccttct taagttctgc   2013720
ctctttgttg tctttagaag cagttccttg accacaggcc acaagcacaa cagctacaag   2013780
agctgttaca agcgttaaaa acactttcca tgttttcttc attttgattt cctcttttct   2013840
ttttcagaaa cattctaatt ctacgaacgt ttccatttaa tcacatattt ttcactgata   2013900
tcgaccagct tcatacccaa aagactgata atcgacacca gaataataat ggcaaacatg   2013960
gtatcatact gaaacagttt tttagactga atcatataaa caccaagacc ttcaaaacct   2014020
cccaaccact cagataccac agttgtgata aaggcgtagg agacactgac cctcagacct   2014080
gcataaaagt aaggcaggct aactgggatt ttaaaatgcc acaggatttg ccaaggcttg   2014140
gcccgcatca gactaaacaa ggtcagcata tccttgtcgc aatgcctaaa accgtccaaa   2014200
atactaacga tgatgggaaa ggttgtcgtt aagataatca agacaatctt gggcaaaatc   2014260
ccataaccta gccacaagac caggatagga gctatggcaa tggtcggaat ggtctgaatg   2014320
accaccatca tagggtaaat caggtcattg agccaagtca aactatccat gagcacagcc   2014380
ataagacagg caatcaaaac tcccaaaatc agccccagta aagccactct caaggtcgcc   2014440
cagctatggt gccagagaaa ttctctgtca cgaacaaagg gctggagaat ttcaagaggt   2014500
gtcggcagga taaacttggg gagaagttta agaaaacctg ctaactgcca gattgacaat   2014560
actccgagaa agcccaatag actaatgtgt cgtctcagta tacttctcaa gtttctcatc   2014620
aatacttaaa atctctccta catttatttt gacattggca aagacattgt ctgcctcctg   2014680
ccctgccact tccagcgctt cttttagaat gcgcataagc tcatcaaact ccccttccaa   2014740
gaccgtttca aatggtgtca ctaccatcgt cacttcttga gtttgcagat aagcaatgac   2014800
ctgatcaata acagctatcc gatcaatccc ctgtactagg ggtaaaactt gcaaggcaat   2014860
gcttgctttc ataagaacct cctcttctcg ttttcctttt taaaaaaaga aaaaccttta   2014920
ccatacatgg aaaaggtgca aaattagact aagtatcgtt ccctccgctg gcattaccca   2014980
gatcaggtgc ggtcgaagtt taacacttcc tctcagactg tacacagact cccatatatt   2015040
atatgtatat atgatagcgc aaaataagaa aaatgtcaag gaaactgctt acagaaaaga   2015100
gcaggaaatt tctcctactc caattttcta tactcgttct ccatcactgt ttactctgta   2015160
gccatccacc gtcgtattaa cagctaaggc gcctgaagag taagaataat accacttacc   2015220
agagacctgg taccagcctg ttttcattgc ccctgaacta cccagataat accacaaacc   2015280
attttccttt aaccatcctg tctgcatttc accagataat ttcaaataat accagctaga   2015340
accgtctttc agccatcctg ttgatttaga accatttgat ttgaaatgat accaactacc   2015400
atttattttc ttccaaccga cagttgaact actatgggat ccatagctag agatgtttcc   2015460
tgattgattc tgataatttt gtgaagaagt cactccctct agctgtatat agcgacgact   2015520
tccgttataa gccgtataac tcaaccactt gtagccgtct ttttcgagaa tttgatcata   2015580
atgaaccttc tctccaggat aatagtaatc aatcacagtt gcactaacta ggggttcagt   2015640
tttgatagca gacttggtct taaaataatg agttccacct gttgaagaaa gaacagaatt   2015700
acctagagga tttttattca cagcctccaa ttgaacataa cgatagcttc cattataggc   2015760
agtataactc aaccacttat agccgtcttt ttcaagtatc tgatcataat gaaccttctc   2015820
cccaggataa tagtaatcaa tcacagttcc gctagctaga ggttcagttt taatagcaga   2015880
cttggtctta aaataatgag ttccgcctgt tgaagttgag gattgactat tcccaacact   2015940
gccaccatcc aaatctttaa aatgaataaa tcctgtcatc gtgtttgctt ttataactcg   2016000
tttattatag gattctgtat aaccatagtt atattcctca atctcaatct gatctcccat   2016060
tacatttgac acccaggcaa catgaccata agttcctgca gtagaccaag taatggaacc   2016120
aatcgtcggt gtattatcta cacgataacc ttcccgacga gcacgatgtc cccattcatt   2016180
cgcatttcca taagctgccg gaatttcaaa accattgaca ttactcaaac gaaaggctac   2016240
aaaagaagta cactgacgag aatacatgcg ccactgatca atctcctggc tcccattttt   2016300
ataataagca ggataatcat ccccacgcgc aatcgatcca tttcctctgg aataggcata   2016360
gacactatca ccagctgcta gcatcaatcc tactactaaa aaaggaacaa gctttttaac   2016420
tgacatcttc aagtaataac ttgttcctct tgctataaac ggtaaaattt tcattcttcc   2016480
tccttgaaaa ataatataaa gcgatgattg ccttcaccta aattattcgg agaaaaaaga   2016540
aaaagtgaga aaatttctca ctttagtcaa gataatgaat caaattcttt tctgtaagaa   2016600
tatctgagta agtaaaggat tcaacgtaaa cattaacttg tttatctcct tccacatccc   2016660
caaactccac aataaataga gatggataaa cttcaattag cttacccaat ctattttttt   2016720
ggcgcttacg accattctcc aaagtcattt ctacgacttg tccctcatgt gccttgattt   2016780
cttctttgat ttttttcatc ttggctacat ctgtaaatgc atctgacatc ttatgcctcc   2016840
ctctttgaga tacttgaaaa tttattgtat tctttttgga aaatcaattc cactgttcca   2016900
cgagctccac tacggttttt ctcgataata acttccacct tattatttgg gataccctcc   2016960
tcttcttcac caccacgttc atagtagtca tcgcgataga gaaaagctac gatatcagcg   2017020
tcctgctcaa tagacccaga ttcacgaata tcagacaaga ccggtctctt gtcctgacgt   2017080
tgttctacac cacgagaaag ctgactcaga gcgattactg gaaccttcaa ttccttggct   2017140
agtattttca actgacgaga aatttcagaa acttcttgtt gacgattttc tcgaccagtt   2017200
cccgtgataa gttgcaaata gtctatcaaa atcaaaccaa gatttccagt ttcttgagcc   2017260
aatttacgag aacgagaacg aatctctgta atccgaatac ctggcgtatc atcgatatag   2017320
atactggcgt tagctagatt accctgagca atagtatatt tttgccactc ctcatctgtc   2017380
aattgccctg tacggataga atgtgactcc actaagcctt ctgcagctaa catacgatct   2017440
accaagcttt ccgcacccat ttcgagtgaa aaaatagcaa ccgttttgtc caacttagtc   2017500
ccaatgttct gagcgatatt caaggcaaat gctgtcttac caactgctgg acgagctgct   2017560
aagataatca actcctcctc atgaagtcct gttgtcatat gatccaaatc acgataacct   2017620
gtcgcaatac ctgtaatatc ggtcgtttgt tgcgagcgag cttccagatt tccaaagttg   2017680
agattcaaca catctcgaat gttcttaaac ccgcttcgat ttgcattttc actgacatca   2017740
atcaaccctt tttctgcctg agcaataatt tcatcagctg gttgtgacgc ttcgtaagct   2017800
tggttgacag actctgtcaa cttggcaatt aaacgacgta gcattgcttt ttctgcaaca   2017860
atcttagcat aatactccgc attagcagaa gttggcacag aattaacaat ctcaaccaag   2017920
taagacaagc caccaatatt ctgtaaatca ccttgattat caaggatagt acgaaccgtt   2017980
gttgcatcta tggcatcacc acgatcggat aaatcgacca tggcttggaa aatcaaacga   2018040
tgggcatact taaaaaagtc ccgagactca atgtattctc gcacaaaaac aagtttactc   2018100
tcatcaataa agatagcccc taaaacggat tgctcagcta agatatcttg aggttgtact   2018160
cgtaactctt ctacttctgc catcagactt cccttccttt tacaatcttg tcaagaaggt   2018220
gtaaacttat ccttctttca cacgaagatt gattacactt gtgatatctt gatagatttt   2018280
cactggcaca tcaatcaaac caaccgctcg aatcggagct tgtacttgaa tatgacgttt   2018340
atcaatctta attccaaatt gcttttgcaa ttcttctgca atcttcttat tggtaataga   2018400
accaaaggta cgaccatctg gaccaacttt ttcaacaaat tctacaacag tttcttctgc   2018460
ttcaagttgt gctttaattg cttttccttc tgcaatcatc tcagcgtgag ctttttcttc   2018520
cgatttttgt ttaccacgaa gttcacctac agcttgagca gtcgcttctt tggctagatt   2018580
ctttttgata agaaagtttt gcgcataccc tgttggtact tccttaattt cgcctttttt   2018640
accttttcct ttaacatctg ctaaaaagat tactttcatt cttctttctc cttttccttc   2018700
atttcattta atacaatttc tgtcagtttt tcacctgctt ctgacaaggt tacatcttta   2018760
atttgagctg ctgccaaatt aaagtggcct ccaccgccta actcttccat aatccgttgt   2018820
acattcagtt tactacgact tcgagctgag atagagataa atccttgtgt attcttcgca   2018880
agaacaaaac tcgcttcaat acctgacatg gctaacatgg catctgctgc cttactaata   2018940
acaactgtat catagcattt catgtcctta gcctctgcta ttagtacatc tgaacctaat   2019000
ttacgcccct gtaaaataag ttcattgacc tcacgatatt cttcaaaatc tgtcgcagcg   2019060
atttcctgga tagcaatact atcacttccg cgcgttctga gatagctagc aacatcaaat   2019120
gtccgactag ttactcgcga ggtgaaattt ttagtatcca acatcatacc agccatcaag   2019180
acacttgctt gcatacgact caaacgattt ttcttagaat tctggaactg aatcaattcc   2019240
gttaccaact cactggcact acttgcacca ctttcgatat aagtaataac cgcattatct   2019300
ggaaaatcct gatcccttct atggtggtca ataacaatgg tttgggtaaa taaatcataa   2019360
aattcttttg ataatgttaa ggctgtcttt gaatggtcta caagaatcaa caaagaacga   2019420
ttggtcacca tccccattgc atccttaaca gacaacaact tcgtaactcc ttctttttct   2019480
atgaatgaaa cagctcgttc aatatctgga gacatttgtt cttcatcata aagagcatag   2019540
ctattttcaa tcacattgct ggcgaacaac tgcataccta cagcagagcc caaagcatcc   2019600
atgtctaaat ttttgtgacc gactacaaaa acctgatcta cactccgaat cttatctgaa   2019660
atagctgtca tcatagcgcg cgtacgagtc cgtgtacgct tgattgaagc agcagaccca   2019720
ccaccaaaat aaactggatt tttcgtttcg tcgttttcct taacaaccac ctggtcgcca   2019780
ccacgtactt cagccaagtt caaattgagc aaagcaactt tccctatctc atcatgattt   2019840
ccatcgccat aagaaaatcc catacttaag gtcaagggca actgtctctg tttcgactct   2019900
tctctgaaag catcaataac agaaaattta tcattcatca agccctcaag caccgtgtag   2019960
tcagtaaata gataaaatcg atccatactt acccgacgag aaaacatcat gtgtttttct   2020020
gaaaactctg atataaaatt agctacaaaa ctattgattt gactaatatc tgactcagaa   2020080
gtttcatcct ccaaatcatc ataattatcc acagagacaa tcccaatcac tggtctactt   2020140
gttaccaatt catctgttat ggcttgttcc ctggatacat ctacaaaata caaaacaccg   2020200
gaagaagcat ccatatgaac agcataacgc ttctcaccaa gcttggcata agtagacgga   2020260
tttcctactg aagccttgat aatcgtttga acagcttcta aatcaaaatc accatcttcc   2020320
ttggtcaaaa tcaattcagc atagggatta aaccactcaa cctctccaga agataaattc   2020380
aatttcataa cacctacagg catctgttcc aatagagctg tcaaactttc ttccgcttgg   2020440
tggtttacat actgtatctg ttctacatca ctccttgtat aatgcactct cagtttctta   2020500
aataaaaaaa catagcctcc tacaaaaaga aacaaaatta aaaccgtcaa cagattatta   2020560
ttaacaaaaa taatgaaagt ggataagact ccaaacgcaa tcaatcctac tagaatagga   2020620
aaaattggac ttacataaaa ttttttcatt caaaacctct tggcacccat tataccataa   2020680
tacccctcaa aaagcgactt tttaaaagtg taatcagtaa ttctatcaat tataagaaaa   2020740
aggtagttta caattcagta aacctacctt tacacatatt gaaattaaga ttctttaacc   2020800
tctaacaaac caatttcgcc atcctcacga cgataaatca cattggttgt ctgatcttca   2020860
acatccacat agataaagaa atcatgcccc aataaatcca tttgtagaat tgcttcttcc   2020920
aaatccattg gttttaaatc aatttgtttt gaacgaacaa ctttagactg gacaatattt   2020980
gaatcttcca ccaaagcatc tgtaaataat tgaccagttg ctaccttatt tttattttta   2021040
cgctcgattt ttgttttatt tttacgaatc tgacgttcaa ttttatcagt tacaaggtca   2021100
attgaaccat acatatcttg agatacatct tctgcgcgga gagtaataga tccaagcgga   2021160
atcgttactt ccactttagc cgttttttca cgataaactt ttaagttaat tcgggcatcc   2021220
aactcttgtt ctggttggaa gtacttttcg atcttttcga gtttagaaac tacataatca   2021280
cgaattgctt ctgttacttc taggttttca ccacggatac tatatttaat catatgagta   2021340
ccttctttct aaacattttt gtttttatga ttttattata acgctttcat tctatttttg   2021400
caaatttttt cctcatctta caagggaaaa tgtttttaca tccttagcac cagcttcttc   2021460
caacagtttc ttaacacgat ttatagttgc tcctgtagta tagatatcat ctataagtag   2021520
gattttttta ggaatagtga ctccactttt aataaagaaa ggaagttctg tccccaagcg   2021580
ctctgaacga tttttagaag aactggctct ctcttctctt ttctctaata aatccagata   2021640
ctcaaagcct gctgcctcta ccaagccctc aacctgatta aatcctctat tagcatatct   2021700
atcaggactt aggggaatta caacaaattg atactctttg tactttttca actcctcact   2021760
taaaaatgaa gcgaaaactt ttcttaacag gaagtctcca tcaaacttat accgactgaa   2021820
aaaatccttc atagcttgat tgtaagtaaa aatcgctcta tgactgactt caactccctc   2021880
tttacaccaa agttgacaat cttgacactt tgttgacaac tctgttttca tacaatttgg   2021940
acagttctct tccccaattc tttcaaaagt agaatcacag tctgaacaaa gacaagagtc   2022000
atcattcctc agaagtaaga gactactaaa agttaaaaca gtcttcatag tctgcccaca   2022060
taacaagcac ttcatagacc agcctcctta ttcatcatct gaatttcctt aatcgccttc   2022120
ttgattgaag catttaaccc atcatggaag aaaagcaaat ctcctgtcgg tctatccatg   2022180
cttcgtccaa ctcgtccacc aatctgaatc aaactagact tggtaaacaa acgatgattg   2022240
gcctctacta cgaaaacatc cacacaaggg aaggtaactc cgcgctccaa gattgtcgta   2022300
ctgataagta ttgtcagttc tccatctcga aaagcttgta cttgctctaa tcgatcctct   2022360
gttacagaag atacaaagcc aattttctca tttggaaatt gctcctgtaa gatttctgct   2022420
aactgctccc ctttcttaat ttctgaagca aaaatgagta acggataagc tgtctttctc   2022480
tgcttctcaa tataggactt taactttggt gacaaacgat tcttgtctaa gtagcgatta   2022540
aaatccgata accaaattgg ttttggaata atcaacggat ttccatgaaa ccgtctcggt   2022600
aaattcagtc tttttagttc tcctaaacgg acctttttat ctaactcatt ggtcgaagtc   2022660
gctgttaaaa agattctcaa tccattctcc tttacactat tcttgacagc gtggtaaagc   2022720
atgggattat caacataagg aaaagcatct acttcatcca ctatcagcaa atcaaaagct   2022780
tgataaaact tcaataactg atgggttgtt gcaacaacta gtggtgttcg aaaataaggt   2022840
tccgattctc catgtagcaa agctatcccg caagaaaaat cctgttgcag gcgcttgtac   2022900
agctccaaac aaacatctat gcgaggacta gccaaacaca ctgcaccacc cgcattgatc   2022960
actttagcca ctacttgata aatcatttct gtctttccag ctcctgttac cgcatgaact   2023020
aaggttggct tttgcttgtc tactacttga agcaatccct ctgacacctt ctcttgaaaa   2023080
ggagttaatt ggccgcgcca tttgagaaca tcttgctttg gaaaatcctc ctgcggaaaa   2023140
tagtataaag tttgatcact tctgactcgc ttcatcagca agcactctcg acaatagtaa   2023200
gcaccgatgg gcaaatacca ttcttctaga atagtactat tacagcgttg acagaaaagt   2023260
ttccccttct cctttctcat tgctggaagt ttctccgcca actgacgttc ttcttctgtt   2023320
aattcattct cagtaaataa acgaccgaga taatctaaat ttactttcat acttctttat   2023380
tcgtaaaaac tagcacttta gatgattttt tagtacaatt aaatcatgga atttaggaca   2023440
attaaagagg acggtcaagt ccaagaagaa atcaaaaaat ctcgctttat ctgccatgcc   2023500
aagcgtgttt atagcgaaga agaggctcgt gacttcatta ctgccatcaa aaaagaacac   2023560
tacaaagcga cacataactg ctctgccttc attattggag aacgtagtga aattaaacgt   2023620
acaagtgatg atggtgagcc tagtggtact gctggtgttc ccatgcttgg ggtactagaa   2023680
aatcacaatc tcaccaatgt ctgtgtggtc gtgacacgct actttggtgg tattaaacta   2023740
ggcgctggag gactaattcg tgcttacgcc ggcagtgtcg ccttagctgt caaagaaatt   2023800
ggtattattg aaataaaaga acaggctggc attgctattc aaatgtctta tgctcagtac   2023860
caagagtaca gtaacttcct taaagaacat ggtctcatgg agctggatac aaactttaca   2023920
gatcaagtcg atacgatgat ttatgttgat aaagaagaaa aagaaactat taaagctgca   2023980
cttgtggagt tttttaatgg aaaagtcact ttaactgacc aaggtttacg agaggttgaa   2024040
gttcctgtaa acttagtgta aacaatgaat aatacagcgt ttcgttgaca ttctcacaac   2024100
tactttagcg agcaaaataa aaagaggcgt accaaaatat actagaaaat gaagcaattc   2024160
aaacgaaacc tgatatcgtt ttccttcaca cctatttact agaattagct gaacgcaatc   2024220
acttgaaaat taatgacttt gatctatgat atatagaaat ggtatggata gcgttatact   2024280
aaagatatct tatacaaaga ggtattcata tgtctattta taacaacatt actgaattaa   2024340
tcggtcaaac accgattgtt aaacttaaca acatcgtgcc agaaggtgct gcagacgtct   2024400
atataaagct tgaagcattt aatcctggtt catctgtaaa agaccgtatt gcccttagca   2024460
tgattgaaaa agctgaacaa gatggtattc tgaaacctgg ttctactatt gttgaagcaa   2024520
caagtggaaa caccggtatt ggactttcat gggtaggtgc tgctaaaggg tataaagtcg   2024580
tcatcgttat gcctgaaact atgagtgtag aacgacgtaa aattatccaa gcttatggtg   2024640
ctgaactcgt cctaactcct ggtagcgagg gaatgaaagg tgctattgct aaggctcaag   2024700
aaatcgctgc tgaacgtgat ggtttccttc ctcttcaatt tgacaatcca gctaatccag   2024760
aagtacacga aagaacaaca ggagctgaga tactagctgc tttcggtaaa gatggattag   2024820
atgcctttgt tgctggagta ggtactggtg gaacgatttc tggtgtttct catgcactca   2024880
aatcagaaaa ttctaacatt caagtttttg cagtagaagc agatgaatct gctattctat   2024940
ctggtgaaaa acctggtcct cacaaaattc aaggtatctc agctggattt attcctgata   2025000
cacttgatac taaagcctat gatggtatcg ttcgtgtaac atcagatgac gctcttgcac   2025060
tcggacgtga aattggtgga aaagaaggct tccttgtagg gatttcctca gctgcagcta   2025120
tctacggagc catcgaggtt gccaaaaaat taggtacagg taaaaaagtc cttgccctag   2025180
caccagataa cggtgaacgt tatctctcta cagcacttta tgaattgtaa ccgtccaata   2025240
acgaagtcta ttgaaaaatc tccagactag agaactcacg gatagttcct aatctggaga   2025300
tttcttattt gcacttttct tgtacaactt tagtccatgg taaataggcc tctaaaacct   2025360
ctttgtttac gagagtttcc acgtttggaa gacattctag aagataggat agatatttct   2025420
cactatttat aatggattga aataagatat gaacaaatcg attagaacat gatggtaaag   2025480
cgtaatccct tgtttctcag ctttcccaga caaaaaagtc caatagtaag tcagctgact   2025540
atcactctct agcaccctat aagaagtttc atccgcatga agtaagggct gagtcaatag   2025600
tctctctcgc aagaggttat aaaggggctc caaatagtat tgactcgtct tgatatgcca   2025660
attagagatt tccttacgtg tgattggtaa acccatccta gcccaatctt cttcttggcg   2025720
ataattgggt accttcagat taaacttctg atggatggtg tgagcgataa tagaagctga   2025780
gccaaagtta tgcgctaaag gggctttagg aataggagct ttcacaagct tatccagatg   2025840
attatctttt actcgttatg gacaatgcta tatggcataa atcaagtacc ttaaagattc   2025900
cgactaatat tggctttgca tttattcctc catacacacc agagatgaac cccattgaac   2025960
aagtgtggaa agagattcgt aaacgtggat ttaagaataa agcctttcga actttggaag   2026020
atgtcataca aggactggag aaggaggtga taaagtccat cgttaatcgg agacggacta   2026080
gaatgctttt tgaaaacaga tgagtataaa aagaaagtcc tcatttcaat agaaatcacg   2026140
actttctgat gaatttatag taaaatgaaa taagaacagg atagtcaaat cgatttctaa   2026200
caatgtttta gaagcagagg tgtactattc tagtttaaat ccactatatt tggggagtga   2026260
tagaaaagcc cttcatcagc caatctactt gttcaggtgc gagagctttg acatcctttt   2026320
ctgtactgga ccaagtcagt tttccgttct caaagcgttt atataatatc caaaatcctt   2026380
gaccatccca gtaaagaact ttaaagcggt ctttacgtcc accacaaaag agaaagactt   2026440
gatcggagaa aggatccaat tcaaagtggg ttttaactac ataggctaat gagtctattc   2026500
cctgcctcat atctgtcttg ccacaaacaa ggtgaacttg acctaaatca cttagttgaa   2026560
ttatcatagt acaatacctt tcctccgata attatttttt atctggtata ctggaagttg   2026620
gggaattagg atagatacct tgttatgacg cgcttactat gaatttgaag tatagtctcc   2026680
taaatgcact tagcccttat tatagggctt tttgttttaa ttattctaat cgagtgagac   2026740
tggggaaaaa acaatttcag gaaaaatcta agccctatac aaaaaaggaa gcaatttgct   2026800
tcctttctat tattagttat tcaaggctgc tgccattgta gctgcaactt cagcttcgaa   2026860
gtcgtttgca gctttctcga taccttcacc aacttcaaag cgagcaaact caactaccga   2026920
agcgttaact gattcaaggt atgcttcaac tgtcttgctg tcatccatga tgtaaacttg   2026980
tgcaagaagt gtgtaagctt ggtcaacttt agtgttatca agcatgaagc gatccatttt   2027040
acctggaata attttgtccc agattttttc tggtttgcct tctgcagcca attcagcttt   2027100
gatgtcagct tcagcttgag caataacatc atcagttaat tgagcttttg atccatactt   2027160
caagtgtgga agagctggtt tattaaccat tgcacggctt tcgttgtctt ggtcgataac   2027220
gtgattcaat tgtgccaact catctttaac gaattgctca tccaattctt tgtaagaaag   2027280
aactgttggt ttcatcgctg cgatgtgcat tgacaattgt ttagcaagtg cttcgtctcc   2027340
accttcaaca actgaaataa caccgatacg tccaccgtta tgttggtatg ctccaaagtg   2027400
ttgtgcgtct gttttttcaa tcaatgcaaa gcgacggaat gagattttct ctccgatagt   2027460
tgctgttgca gatacgtatg cagcttcaag agtttcacct gaaggcatta tcaaagcaag   2027520
agcttcttcg ttgttagcag gttttccttc agcaatgact ttagctgtag tatttaccaa   2027580
ttcaacgaat tgagcgtttt ttgcaacgaa gtcagtttca gcgtttactt caataactgc   2027640
tgcaacatta ccgttaacat aaacaccagt caaaccttct gcagcaacac ggtcagcttt   2027700
cttagctgcc ttagccatac ctttttcacg aagcaattca atcgcttttt cgatgtcacc   2027760
gtctgtttct acaagcgctt ttttagcgtc cataacaccg gcaccagatt tttcacgcaa   2027820
ctcttttaca agtttagctg taatttctgc cattttaatt ctcctatatt ttttgaaaat   2027880
aggagagccg ggctaagccc cgccctccta ggtaattact atttgtataa attaagcgtt   2027940
gtcgccttct acaacttcaa cgatttcttc aattgaatct gcttgagttt ctaaagctgc   2028000
aaattctgct tcaactgcta ctgcatcctc accttgacgt ccttcgataa tagcgtcagc   2028060
caatttagct gtgatcaatt taacagcacg gatagcgtca tcgttagctg ggatgattac   2028120
atcgatatca tctggatcag tattggtgtc aaccatcgct acaactggga ttcccaattt   2028180
tttagcttct ttaacagcga tttgctcttt atgtgggtca actacgtaca tcacatctgg   2028240
gatacgaggc atatcttcga taccgcccaa gaatttttca agacgcgcac gttgtttgtt   2028300
aagaagtgca acttctttct taggaagaac ttcgaaagtt ccatcttctt ccatacgttt   2028360
aatttctttc aaacgagcga tacgtttttg gattgttccc cagtttgtaa gagttccacc   2028420
caaccaacgg tggttgatga agtattgacc tgaacgtact gcttcttcag caactgcatc   2028480
agctgcttgt ttcttagtac caacgaacaa tacaactgca tcgttagctg ctgcatcacg   2028540
catgaagtcg tatgcttggt cagcgtattt tacagtttgt tgcaagtcga taacgtggat   2028600
tccgttacgt tcagtaaaga tgtacttagc catcttagga ttccagcgac gagtttggtg   2028660
accaaagtgt acaccagcct caagaagttg tttcattgaa attactgcca tgagtatttc   2028720
tcctttttgt ttttttcctc ttcttgactt caactcgcaa aacgacccaa gggcaactgc   2028780
ttcacaattc atcaagaatg agtattatcg ttcacacgac aattttcatt ctaccatact   2028840
tttccaatat tttcaagcta ttttgatata atttttaata gggattgtca cggtaaaacc   2028900
tgaaaagagg gctctattcg agtccctctg taaattaatc tgcataaata tatgtaacaa   2028960
aaccttcaga agttgttgtt ggattgaacc atccacggtg atttccaatt gtacgattac   2029020
ctgcataatt tgattctgat acttggatac gtgttgttga ttcaacagct gtaacaaccg   2029080
ctacgtgacc atatccacca tcattccaac atgcaattgc tccaacttga ggtgttgaac   2029140
ctgtacggaa acctgctgct gctgcacttg tagcccactg tgctccatta ccccagtagt   2029200
ctccagccca aggtgccaat gtttttactc cccatgtaca ttctccaatt ggataacttg   2029260
aagcgtttgt actgtatgtt ggacgaactt ttgcacggac aggtgctgct gcagattcag   2029320
atactgcttg cacttgagct gttaagttag tgtttgctga agcaagtact gattgttgtt   2029380
ggctagctcg tttttcttta taagctgctt ctgctaccgc agctgcacga gcctctgcct   2029440
cagctgctgc tttttgctct aatagacttg ctttttcccc ttcagctgtc gctttctcag   2029500
cagcaagact taattcagca gcttttagtt ctgcctgttt cgtagtcaat gcttgagcat   2029560
catcagccaa tttttgttga ttagcaatta cagtattgat agcatcatta tttgctactt   2029620
gtttttcaga aatagctttt ttatctgcct tttgttgttc taacattttg ttgtttgcag   2029680
atacgatttc actcattgca gcaacacgtg aaatagcttc tgtaattgat tttgagttta   2029740
caatggtatt gatatagcta gttacggctc catttgtttg agcactacga gcttgttttt   2029800
ccaacgattg gttacgagaa acaatgtttt tagaaagttc tgtaatctca ccctcgagtt   2029860
tcttagattc tgcttgtaat ctatcatttt cagcttgcaa gttagactgc tcagcttgaa   2029920
tagctgatac ttgctcctga atttggtcaa cttgtttttg ggcttcttgt tgttgtgctg   2029980
ttaagttact aattttatta tcttgagcag caattttgtc atcagtcgtt tctgcatgcg   2030040
cagttgttaa aacagctact tgagaaacca ttactgtact taataaaagt gacgctaaga   2030100
tttttttctt catattacgt agatactcct tcttttaaag acaatactag tataccaaaa   2030160
aaaggcctaa taaatattac gcctttgtta catttatatg tcgttcttat agataatatt   2030220
tttcaaaaat aaattgaaaa acagtaatcc ataaaaaatt taaaatcatc gtcggtacca   2030280
agctatagac tataaaaatc gacatgctat ctactgtcaa ccctaccata aaagccaaaa   2030340
gataactacc catttcaaac aggaatgtca gcacaatcat agctagcatt cttgtccaac   2030400
gattcaacaa aataacacta ttcaatttat gaaggaaggc tcccaataag ataaataaga   2030460
gagttgtaat ccctattaga tggaaaaagt aaacatcata aaccaagcct ataacaaaac   2030520
aatagactag gtagagatac tctgatactt ctatcgtctc aaataagaga aatagaaaaa   2030580
gaaaatgact agccaaatgt acatggggga aaaatgagcc cagaagctgg ctaatatggg   2030640
cgtcaattag aacaaagaaa ggaagcaata aaaatactcc aactcgcttc aactgtctca   2030700
ttatgaattc cccactaatt ctatcacatc tacattatga gtatctgcac tcaatttaac   2030760
agttacttct cgtgtcaaat agtctgtact atgcgttgtg gcaaccactt caccaacagg   2030820
aatatcagca acgttaaagt ttcctaatcc accagtagtc accttatctc ccgcactaat   2030880
atcgctatta ctatttaatt ggctaatttt aagaacgtca ttttccttgt catagccaat   2030940
aataattcca taaattgtag tagagccatg ttgaatttta acagaaatct tatcagcatt   2031000
ttccgtattt gtcagaaggt tgactatagt agagttctcc tctacttttg aaacactccc   2031060
aatcaagcca ccatttgcaa tagctaacat gttctcagaa gcaccttttg atctacctgc   2031120
atctaaggtc aactcctgct tccaagatac cggagaacgc ataataacat ctgctgctaa   2031180
agtctttgtg gcttgcaatt tagacttcat atcaagcaat tggcgcagtt gttcattttc   2031240
tgtctttaaa ctttccacct catttgattt aacttctaat tggtaaagct gtttcttcaa   2031300
actttcattt tcattatatg ttcgtgtcaa atgagccaaa tctgatttga cagaatcaaa   2031360
ccactgaaaa ggtttttgta caactctatc aaccaatgag attccatctc ctaattttgt   2031420
cacaattgta cttgaataag tcgtcgctaa gagagctgac acaagcagaa cagtgacaaa   2031480
aacaataatg acatattttg attttttaaa acggttcata tccctacctt tatatcaaaa   2031540
actgttacag taacttttta tcaattcctg aaagctacta agattttaag aaaaataaac   2031600
aacaaccaag tacgagaata acaagaatgg tcagcgtatc ctttagagtc catttcaatt   2031660
gtcggtattg acttctgcct tttccaccct gatagccacg cgcttccata gcgatagcca   2031720
aggaatctgc acgttttaaa cttgtcgcaa aaagaggaat caaaatggga atcatcgcct   2031780
ttactttttg aacgatgctt ccttctccaa aatccactcc acgagctttc tgtgcattca   2031840
taatccgagt cgtatcatcc atcaaggttg ggacaaaacg caaactcata gacagcatca   2031900
atccaatttc atgaactgga actttcacac gctttaaagg tgctaataaa gcttcgacag   2031960
ctgatgccaa acttaaaggc atggttgtta aggttaacaa agttgaaaag aaaataatca   2032020
atacaaagcg acaaaaaata atcccagctt gttgcaaagc ataatccgtg attctcacaa   2032080
acgaaaactc aaataaaaca ttcccattag aaatgaaaaa tagttgaaaa atagttgtga   2032140
aggcaatcaa gaaaaacata gacttcaagc cctgaataaa aaatgaaaga gatactcctg   2032200
acaaggcaat aaatatccct gtcgctataa aaagaatcag attcgtcaag gggttattag   2032260
cccaaaacac aatcaaaatc agtagcatca tagcaagcaa tttgctacgt ggatccaatc   2032320
ggtgaacaat cgaatcccct gggatataac gccctaaaat catactatcc atttagcgac   2032380
tccttgaact cctctatctt aatcggtaat cgtttaaatg acacgcctct atcagccaat   2032440
cgtttacaaa aggccgtaat tttaggtact cccaactgaa cttcttccat aaaaacaacg   2032500
tcttgaaaga catcacttgg tttgcccccc tttactaaac gtcccttttc cattacatag   2032560
acttgattcg catattcagc aacatcatcc atcaaatgcg ttaccaagac gatggtcatc   2032620
cctgactggt ggagtttttt gaacagggtc atcaactctt ttctccctag aggatctaga   2032680
ccagctgttg gctcatctaa gactaatata gctggctcca tggcaagtat gcctgcaatg   2032740
gcaacacgtc tcatttgtcc ccctgacagc tcaaacggac tacgatcaaa aagtgattca   2032800
tcaattccaa ccagagccag tttctcacgc gcagtcttca cagcatcttc ttcagaaact   2032860
ccaaaatttt gcggtccaaa agcaacgtcc ttcaaaaccg tttcttcaaa aatctgattt   2032920
tcagcaaact gaaataccaa gccaacctgt tttctaattt gacgaatatc tttattttta   2032980
gaagtcgagg tgattaaggt atcaaaaacc ctcacactcc cttgacttgg caccaataaa   2033040
ccatttaaga gttgtaaaat agttgattta ccactacctg tgtgcccaat taaagctgta   2033100
taagagccat cttcaatcgt caaagaaaca tccgacaaag ctgctgaagc taagggagta   2033160
ccttcttgat atgtaaaatt cacattttct agagcaattc ccatagctta tcctctagct   2033220
cactttctgt caaataattt tcaggtaaat catagccatt ctggctcaaa gattttttta   2033280
attgattagc aaaaggatcg tctaatccaa tttgatctaa atcatttcga gagaaaagct   2033340
cccttggact actagttgat tcaatttccc cttttttcat gaccaatacg cgatcactca   2033400
tggcgacttc ttccaaatca tgggtaatag aaatgaccgt catatcatag tcttttcgaa   2033460
ttccttttac tgtcccaata agttctctac gcccctcagg atccaacata ctcgttgctt   2033520
catctaagat taaaatagct ggtcttaggg ctacaacacc tgcaatggcc acacgttgct   2033580
tttggccacc tgatagacgc gctggctctc tctttttaaa gtccaacatg ccaactaaag   2033640
ccagagcttc ttccactctc tttttcattt cttgacgaga aagtccctga ttttccaaac   2033700
caaaagcaac atcatcttca acagtcgctc caacaaattg attgtctgga ttttgaaaaa   2033760
ccataccgat ttgacgacgt atattccaaa cattttcctc agtcaaacgt tggccatcaa   2033820
ttacaatctc tccggattct gcttccagta agccatcaat taatcgaacc gtcgttgatt   2033880
taccactacc attatgccct acaatcgaaa gccattctcc acgtttcacg tgaaacgtaa   2033940
tatccttcac atcgtagtag ttctgatttt ctttatagcg aaaagaaaga ttttttacat   2034000
caattattga tttcatttcg aaccaaatgt ccctttaaat acataggcac tacccttgaa   2034060
atagtcatag ccagagtaga tagtgaaaaa taaggctaca taaagtagaa cttgaccaag   2034120
caaagtccaa tgtaatagca agaaaataat ggcaaacatc tgactaaaag ttttaatttt   2034180
tccaggcatt gctgctgcta aaattgttcc accagtttca accaataaaa gccttaaacc   2034240
tgtcacagct aactcacgac agataatcac tgcaacaatc caagccggag ccatacctaa   2034300
ctcaatcaac ataataaaag ccgacataac tagtaactta tccgccatag gatctgcaaa   2034360
tttaccaaaa ttactgacca cattccattt acgagctaaa tatccatcta aatagtcggt   2034420
aatactggca acagcaaaga taatagctgc aactatatga ctctctatcg aatttcctat   2034480
cgttaaaata aagataaaaa taggtataaa gagaattcga cctattgtta agagattggg   2034540
aatttgttct tttttcattc gtttttcctt aatttttagt aaaggttaca gtgatttgtc   2034600
cagtctgagc tgttaatttc gataaatcaa cagtctgatt atctactgtc aaatcaacac   2034660
cttttacaac acctaacgta attgttacag gacttttagt tgcaactgtt gcttctgcac   2034720
ttttcttctt tggcgataag gttacaccgc cctcaagttc gctttctgaa acactgaccc   2034780
aacttgtaac atctgaaact gccaattgca atttaactgt ttccttactt gtcttataag   2034840
cgatttctac atgatttcct tcgcctgata cacttatagc tgattctata ctagaagaac   2034900
tactacttga ggagtgggga acagagctag ttgaacttgt tgattgaacc acactgtaat   2034960
tagaaagaga aggctcctct ggttgagttt gaatatagtt ccaaacataa taagtcacaa   2035020
aaattaaaat cgataaagca aaaaggataa aataaaataa aggtaaaaat gatgtttttt   2035080
tcttcttttt cttacttgaa cgtctacgac ctgtcaactc atcttcatca acatctactt   2035140
cctcataagt aatcatactc ccagaatcat aagcatccaa aacaatttgg tcatctaact   2035200
caacagccca tgcatatttt ttcaagaaag aacgcgtgta aaaaggactt ggaagttgat   2035260
cgaaatcgtc tgcttccatt gcttccaaca tatctaactg gatttctgtc tttttctgca   2035320
attcatctaa actcaatccc tgattgattc tagctaatcg taaaacctct ccaattgttt   2035380
tttttctcat acttgtcatc ccttctttct agtgtctatt ataataggtt actacgatgg   2035440
gaatattgta aaatcaacta tgtcaccatc atctattaaa tgatgtccag catcaaggac   2035500
atcctctaaa gtaatttcct gtaaaatttt cggcaaatca aaaattatct caccattttc   2035560
aaaagcatca tattgcgttg caataaattc aagagagttc atgctactga aaaattcgcc   2035620
aaacatctct cttttgataa tatctaaatg ttcctctgta atatctaaat cctttgtaaa   2035680
attacgaata gccttcctaa attgatgaga caaagcaact ggctctttcg tatccattgt   2035740
caacatgaca aaatgaaagc gacttgttat ttcaacttcc agagataagg acgcatcaat   2035800
tttacctgat tcataacatt tttgaaaacg atccgaagtc caaccaaaca tcattgcaaa   2035860
caataatttt aataaaatat gatgtcgata gcaatccgct tcagaaactt ctcgcttacc   2035920
tctaactcca atcgctagtt tgggagaaga tacttccatt ctcatactat ctgttggctt   2035980
tacaggctgt aaaaacaact tttctcttgc tacttcctga aaatctgaat ctttcagttc   2036040
tttgctttca aaatagtcct gtactcgctc cacatcaaaa ttaccaacta aaaacagaga   2036100
catgtttaca ggtttgtaaa actttgtaaa attttcttgc aaattagtta gattgatttg   2036160
ggaaatggac tcctcacttc caactatatc agttgctaaa ggtgtaccag gatacaaatt   2036220
cgctaaagtt gaaaagaata aacacgaatc tggatcatct tggtacattt ctcgttcttg   2036280
ctgaataata tcctgctctg tcagaatgga agcttcagta aagtgtgctg atgttaccaa   2036340
ttcatcaagt aaatctaaat tttctaaaaa ataatccgtt gctgaaaaaa gatagtttgt   2036400
ttttgtaaag cttgtaaagg cattactatc tgcacctaga ctcgtaaaag ccgacatcaa   2036460
atcactagaa tcttctctct caaataattt atgttcaaga aaatgagcaa ttcctccagg   2036520
atattgtttt acatctccgt caacttctgt gacaaacgta tctaccgaac caaactgtac   2036580
agtgacactc ccgtaaacct ctttaaattc ctttttaggc aaaagagcaa ctgtcaatcc   2036640
gttggccaaa cgagttcgat aaaccatttc ttttacagct ggatagtatt tttcttcaaa   2036700
aacaaccttt gtcattctat tccttccata aagtaaatcg cttgtagttt cacattatta   2036760
gctactctac aaatagcatc tttgtcaatt tgttcaagct ttgcaatcca acttttaaag   2036820
tctgctgaag attttccaaa taaggcattt tgataagcac gttcaatcaa tgaagattga   2036880
ttatcttgag aaagtaacaa cgaccaacga atcatttcct tggtctgatt taactcaaac   2036940
tctgtaaaat aacctttttt taaatcaagc agttgattat tcatcatttt acgagcctgg   2037000
ttacgatttt ctcgattgat accagcatac atcctcaaga atccactaaa taaatcaagc   2037060
tcacttgaaa tggtataagc taatccagca ttttcacgga catttgtaaa gagcttagag   2037120
tgagcaaatc caccaagtaa accattcatt acaatcatgg gtaaatgttg ctcatcacca   2037180
tatttagaac agtaatgata acctaattcc aaaatggatt gtcccacatt tttccgaacc   2037240
ataccttcct gaaggatatt agaataaggt tgacaatact gaaccttcac atctcctttt   2037300
cgacctttaa agccaaatga ttctaataca ttttgaattt caacctcatt aaaatcacct   2037360
aggaaaaaga aatctattcg atcattggct aaaaattctt ggaaacaaga ataagaactt   2037420
tgtggagttt cagctaaaat acgatttcgt aaatcactat attccaattg aagacgttca   2037480
tcatgaaaaa acaatttatc caattcttta tgtgcaaaat aaaaagaatc atccatatca   2037540
gctgctaaac ttgctagcaa ttgttttttc tcaatttcaa ataaggccgg atcaaaccca   2037600
ttatcaacta ctacgggtga aaaaagagtt tcttttacaa gttccaaaat ctgagaggtt   2037660
agcacgtttt tcctacttaa aaactcatca cgaacatagg taaatgtcaa ttctataatg   2037720
tggctttgcc ctcttctgaa acaattggtt gacatatctg taccgtatag actggccaag   2037780
tgtctcctca aatcttgaga agtggggtac atctgattag cagtctctag catacttgca   2037840
ctcaacatgt gacctgcaat cgtatcaagg gataatggag cggtaaaacg cacggtaatt   2037900
ttgtttgttt taaacttttt tgattggata aaatgtgttg aaattccatg cactaactcc   2037960
atgatttacc tccttatata cagacttcta ttatatcacg aaaacctgaa attttcttgt   2038020
tccctgtaac acttttgaaa taaaaatcgc ttacatttct cgctgtctct ctcactattt   2038080
ttaggaaaat atggtataat accaaagatt gaggtgaatt atggaataca aattatttga   2038140
agaatttatt accctccaag cactattcaa agaacttgga attacacata gcggaggagc   2038200
tattaaatca tttctctctg aacattctgt ttactttaat agggaattag agagccgtcg   2038260
tggaaaaaaa cttcgtattg gcgataaagt tgacatccct gacatgaaca ttgacatctt   2038320
gttgacacaa cctacttctg aagaacaaga tgaataccaa gctgataaag ttgaaaaaga   2038380
acggatcgct aaacttgtca aaaagatgaa taagggagtt aaaaaagaca aatcgaaacc   2038440
tgcttcatca cctaaaagcc aacaagctcc acgattccct ggtagataat catgtggcta   2038500
caacatctat ctctcaagac ttttcgtaat tacaaagaaa cgaaaataga ctttaatcct   2038560
aaattgaatg tctttttggg acgtaatgca caaggaaaaa caaacatgtt agaggctatc   2038620
tattttttag ccttaacgcg tagtcatcga actcgaacag ataaaaatct cattcatttt   2038680
gatgaggaac aacttcatct ttcaggtctc gttcagaaaa aaactggatc cattccccta   2038740
gaaatcgaac taacacaaaa aggtcgtgta acaaaagtta atcacttaaa acaggcacgc   2038800
ctttcagatt atgtaggaca catgaatgtt gtcttatttg ctcctgaaga tttacaacta   2038860
attaaaggag caccttcgat tcgacgaaaa ttcattgata tggaacttgg gcaaattaag   2038920
ccaatctatt tatctgactt aaccaattat aaccacatcc taaagcaaag aaacacttac   2038980
ctaaaatcag ctcaaaaaat agatgaaaca ttcctttctg tgttagatga tcagctagtt   2039040
gattatggat gtcgtgtaat gaatcaccgc ttagatttca taaaaaaact agaatcattt   2039100
gggcgtaaga aacattttga actctctaat cagatcgaag agttgtcaat atcctatcaa   2039160
tcttctgtca atataactga caaacaaaac ttatccgaat ctttcaaaat tgctttagaa   2039220
aaaagtagat ccagagattt atttaaaaag aatactggtg tcggtcctca tcgagatgac   2039280
atttcttttt atataaatgg gatggatgct agtttcggaa gccaaggtca acatcgtagt   2039340
ctcgtcctct cgataaaatt agcagaaatc gaattaatgg aaagcattac cacagaatct   2039400
cctatattac tgcttgacga tgtgatgagt gaacttgaca acactagaca gttaaaatta   2039460
ttagaaacga tttctcaatc aatccaaacc tttatcacaa caacaagctt agaccatctt   2039520
caaaatctgc cagaaaatct aagtatcttc actattcagg atggtaaagc tgctgtaaat   2039580
ggaaattgac aacattgtaa aagaactcct gttttcactg gagttctttt cattgttttt   2039640
tacatagaat aatttggtgc ctcattagta atttgcacat catgaggatg gctttctttc   2039700
aaaccagcac cagacatttc aataaattga gcattatcgt gtagttcttt aaggttagct   2039760
gcaccacagt aacccatacc agagcgaata ccaccaatca tttggaaaac aatatcagct   2039820
gccgctcctt tataagcaac acgaccttca attccttctg gaacaagctt gtttgcttca   2039880
ttgacagaac cttggaaata acggtcgctt gaacctttct tcatagcagc aattgatccc   2039940
ataccacggt aagtcttgaa tttacgtcct tggaagattt cagtttcgcc tggagcttca   2040000
tcagttccag caaacataga tccaagcata acagcatttc cacctgcagc aagtgctttt   2040060
acaatatctc cagaatactt gatcccaccg tcagcaataa tcgttttacc atattcgcgc   2040120
gcaacagctg cagcatcgta gatagctgtt acttgcggaa caccaacacc agcaatcaca   2040180
cgagtagtac agatagaacc tggtccaata ccaaccttaa caacgtctac acccgcttca   2040240
taaagggcac gtgcaccttc agcagtagca atatttccag caatcaaagt ccgatctggg   2040300
aaatgagcac gaatctcggc aattttacgc aagacacctg cagaatgacc atgtgcagta   2040360
tcaataacaa tcgcatccgc tcctgcctca aaaagagcct ctgcacgttc aaatgtatct   2040420
gaagtaacac ctactgcacc tgcaactaga agacgaccaa actcatcttt agccgcattt   2040480
ggaaactcaa taactttttc aatatctttg atagtgatca aaccagaaag actgccttct   2040540
tcatcgacca acggaagttt ttcaatacga tgctcttgaa gaatactctc agccgttgca   2040600
agatccgtac ccacaggagc agtaacaaga ttttcactag tcatatggtt tgaaattggt   2040660
tgattataat ctgaaataaa acgaagatct cggtttgtca aaataccaac caatttacga   2040720
ttttcaagtg tttcaacaac tggaacacca ctgatgcggt aacgacccat aagctcatct   2040780
gcttcagcaa ttgtatgttc aggcgtcaag aagaacggat caataataac tccattttca   2040840
gaacgtttta ccttacgaac ctcgtctgct tgttgagcaa ttgacatgtt tttatggata   2040900
actccgagac cgcctgcacg agcaatagca atggccattt gactctctgt aactgtgtcc   2040960
atggcagcgg taataattgg gatatttaaa gtcaaattat ctgccaattt agttgttaaa   2041020
tctgcatcgt taggcaacac atgactttca gctggaataa gcaatacatc atcaaaggta   2041080
aaaccttttt tcaaaaattt agtgtcccaa ttagacattc gaagtttcct cttttctttc   2041140
tttttgagct tgactctttt tatattgtat ctatcatacc attctataaa aatttgtcaa   2041200
atgttacagg ggtaaataaa aaactatctt ttcttcgaga tagaaaagat agtttcttgt   2041260
aaaataaact tagttaaagt aatgaagtcc cattgcccct tttacctcag atagggtttg   2041320
acccgcaact tcacgcgctc tttcactacc tttttgaatc atattataaa cttctcccat   2041380
atccttagca aattcaatac ggcgctcacg aataggaccc agttcacgtt ctaatatttc   2041440
aagtagataa cgcttggtct tcacatcacc aagaccacct cgttgataac gttctttcat   2041500
atcagcaatt tcttgagcat cttctggacg accaaaaaca tctagataat ggaaaaccat   2041560
atttccctca atcttacctg gatcctcaac gcggatatga tctggatctg tatacatact   2041620
cattactttt ttacgcaaag tatccgcatc atcagctaaa taaataccat tatttagtga   2041680
tttagacatt ttagcatttc catctaaacc aggcaaacgc cctgctctct cattttctgg   2041740
ataaatacct tccggctcta ccaagacatc acagttatat gcattgttaa aagaacgaac   2041800
aatttcacga gtttgctcaa tcattggttt ctgatctgtc ccaacaggaa cataattagc   2041860
cttgaaagct gtgatatcag ctgcttgagc gattggatag accaagaatc ctgtcggaat   2041920
gctttctcca aatcctttct gagaaatctc tgtcttgact gttggatttc gctccaaacg   2041980
tgctaacgaa actagattca tataatacat agacaactca gccaactctg gaatctggct   2042040
ttgaataaaa atagttgact tatttggatc caatccaact gcaagataat ccaaagccac   2042100
atttccgata gactctacaa tggtttgagg atctttggca tgatctgtca aggcttgttg   2042160
gtcagccaag aacacaaaca tatcatactt atcctcttcc tgtaataata ctcgattttt   2042220
gagacttcca acataatgtc caatatgcaa ttttcctgtt ggacggtctc ctgttaaaat   2042280
aatgggttta gtcattttgt tctccttcga tatagtcctt tcaattatag cattttttta   2042340
atgaaataac cgtaatttat caaaataaat cagccttgct ttttacagat ttgtgtaaag   2042400
gatactgtaa atataattta cacaaaattg acaaataaaa atttgaatat ttctgtattt   2042460
tctagtagaa taaatatatt acacatatag gagaaaaaca ttgcttacag tatctgatgt   2042520
ttcactacgt tttagtgatc gcaaactttt tgatgatgtc aatatcaaat ttacagaagg   2042580
aaatacttac ggattaatcg gtgctaatgg tgccggaaaa tcaacctttt taaaaatttt   2042640
agctggagat atcgaaccta ctactggtca catctctctt ggtccagatg aacgtctctc   2042700
tgttcttcgt caaaatcact ttgactacga agatgaacgt gccattgatg tcgttatcat   2042760
gggaaatgaa aaactttata gcatcatgaa agagaaagat gctatctaca tgaaggaaga   2042820
tttctcagac gaggacgggg ttcgtgctgc cgaactcgaa ggagagtttg ccgaacttgg   2042880
aggttgggaa gcagagagtg aagcctctca actacttcaa aacctaaaca ttccagaaga   2042940
attacactac caaaacatga gcgaattggc caacggtgaa aaagtaaagg ttctcctcgc   2043000
caaagcactt tttggtaaac cagatgttct tctcttggac gagcctacta acggtttgga   2043060
tatccaatcg attacttggt tagaagactt cttgattgac tttgataaca cagttatcgt   2043120
agtatcccac gaccgtcact tcttaaacaa agtttgtact cacatggccg accttgactt   2043180
tggaaaaatc aaactctatg tcggaaacta cgacttctgg aaggaatctt ctgagcttgc   2043240
tgctaaattg ctagcagacc gtaatgctaa agcagaagaa aaaattaaac aattgcaaga   2043300
atttgttgct cgtttctctg ccaatgcttc taagtcaagg caggcaacat cacgtaagaa   2043360
aatgcttgat aagattgagc tagaagagat tgtgccatct agtcgtaaat atccatttat   2043420
caactttaaa gcggaacgtg agattggtaa tgatctcttg acagtagaaa atttaactgt   2043480
aaagattgat ggtgaaacta tcttggataa tattagtttc atcttgcgtc cagatgataa   2043540
gacagcactt attggacaaa atgatattca aacgactgca ttaattcgtg caatcatggg   2043600
agatattgac tatgaaggaa ctgtcaagtg gggagttaca actagtcaat cttacctacc   2043660
aaaagataac tcagctgatt ttgcaggagg agaatcaatt cttgactggt tgcgtcaatt   2043720
cgcaagtaaa gaagaagatg acaatacttt cctacgtggc ttcctcggcc gtatgctctt   2043780
ctctggagat gaagttaaca aacctgtaaa tgtcttgtca gggggagaaa aagttcgtgt   2043840
catgctttca aaactcatgc tcttaaaatc aaatgtcctt gtacttgatg atccaacaaa   2043900
tcacttggac ttggaatcta tctcaagctt gaatgatgga ttgaaaaact ttaaagaatc   2043960
aatcatcttt gccagccatg accacgaatt tattcaaact ttggctaacc atatcattgt   2044020
cttatctaaa aatggcgtca ttgaccgtat cgatgaaacc tacgatgaat tcctagaaaa   2044080
tgcagaagta caagcaaaag ttaaagaact ttggaaagac taaataaaac ttcaaaactc   2044140
agttgggtta accaactgag ttttctatca ttctacgagg taacatgaaa tcatttttaa   2044200
aaacatatcg aacctatttt atttctttca tcattcctgt agtgattatg tctggagtat   2044260
atctatctca aagtatctac tggaatagcg acaactctcc tctattagga gatggctttc   2044320
atcaatacgt tatttttgat gtagccttac gaaatatcct acatggaaat agtaatctgt   2044380
tttacacctt tacaagtggt ctagggctaa acttctatgc cctatctagt tattacttgg   2044440
gtagttttct cgcgcctctg gtttactttt ttgatctaac gaatatgcca gatgctatct   2044500
atctgacaac tctcttaaaa tttggattga ttggtctgtc aacctttttt agtttgaata   2044560
aattgtttca atctatccct cagattttaa aactagcctt atctacttcc tatgctctga   2044620
tgagtttcac tgtcagtcaa ttagagataa aaacctggct agatgttttt atcttgattc   2044680
ctttaattat aactggttta catctactga taactgaaaa gaaactccta ttgtacttta   2044740
caagtctgtc aatcttattt attcaaaatt attattttgg atatatgaca gtattgtttc   2044800
ttattttctg gtatctctgt caaatttcgt gggactttaa gactcgaaaa tcatctgttc   2044860
ttgatttcat agttatctcc tttttagctg gtatggctag tttgattatg actcttccca   2044920
ctctatttga tttacagaca catggggaaa aattgactga agttacaaag tttcaaactg   2044980
aaagtagctg gtatcttgat ctctttgcta agcaattcat tggttccttt gacacaacaa   2045040
agtatggggc catcccaatg atttttgttg gactatttcc ctttattttg accattttat   2045100
tttttacgct gaaatctatt aagtttcacg tgaaactcat atatgtaata ttctttgcat   2045160
ttctaattgc aagcttttac atagaagctc ttgacttatt ttggcaaggc atgcatactc   2045220
caaacatgtt tttacatcgc tatgcttgga ttttctctac cttgttaatt tacacagcag   2045280
cagaagtctt aaagcgtctg aaagaactta aagtctggaa ttttttagtt tcgctttttc   2045340
ttgtagtagc aggattttta gctaccatct atctaaaatc gcattattct tttttaacag   2045400
atttgaatat tctgcttact cttgaatttt tggttgtcta ttctctttta ctccttgcag   2045460
ttatcaaaaa gtttatatct gtgaatctat ttgccattct aatctcttta tttatactgg   2045520
ttgaaatgag tttaaatgct tcatctcaaa tggacggaat tgctaaggaa tggggatttg   2045580
cttctcgaag tgcttatagt cgagatatcc cagctatgga atctttctca acatatattg   2045640
gaaatcaatt tactcgtact gaaaaactac aaactcagac aggaaatgac agtatgaaat   2045700
tcaactacaa tggaatctct caattttcat ctgttcgaaa tcgttcatca agctctactt   2045760
tagataaact tggttttaaa tcctctggga ctaatctcaa tctccgatat gcaaataata   2045820
gtattttggc tgatagttta tttggtatcc agtacaatat ctcagacagt cctattgata   2045880
agtatggctt taaagatatc tatcaaaaag ataatcttac cctatatgaa aatcaatact   2045940
ctcttccgat tgcagttgcg agtcaatctg tttacaatga tgtcaagttc aatgaacata   2046000
ccttggataa tcaggcctca tttttaaatc aacttgctaa cgtcaatttt gattattttt   2046060
ctccaatacc ttatgaaaaa acagaaaaaa tagaaaatac taatgatttg attagtgtca   2046120
caagttcttc aaatgaagat gcagcaatcc agtatcaaat tgaagttcca gaaaacagcc   2046180
aagtttatct ctctttcata aaccttcact tttctaacga taaacaaaag aaggttgaca   2046240
tccttgtaaa tggtgaaaaa aagactttta caactgataa tgtcttctcc ttctttaatc   2046300
taggatatac taaagagaaa aaaactttca atatcaatgt tagtttccct ggaaattcac   2046360
aagtatcatt tgaatctcct accttctatc gtttagatac caaaactttc accgaggcaa   2046420
ttcaaaaaat taaagaacaa cctgtcacag tatcaacttc taaaaacaag gtttttgcta   2046480
catatgatgt ccaacaagat acatctattt tcttcaccat tccttatgac aaaggttggt   2046540
ctgcctacca agatggtaag aaaatagaaa ttaaacaagc tcaaactgga tttatgaaag   2046600
ttgacattcc caaggggaaa ggaactatta cactttcctt cattcccaat ggttttatta   2046660
ctggagcaat ctgttccttt acttctctct tactatttgg aatctataat cacagacgaa   2046720
agtcatctaa ggcataaaaa atcgaccagt taatcggtcg atttttttaa tcttcttcca   2046780
ttttcttatg ttgataggct agcataccta aactagtaaa tagaactagt atgacagcta   2046840
ggaaaatgac ttgttgatag agattgtttg tcgtaatccc gaaactgaat agctcattgg   2046900
taaccaggga ttaatagatc taaagaaatc atttgtcaaa gcaagtggat aagtacctgc   2046960
acttgatgct aactgtagta aaagcaaaat aagtgagaaa aaagctccta tacggctatt   2047020
ccacgttgct aaagtggtca ccatagacat gaatactaaa cttgttagga tgatgagaat   2047080
aaatattctc atctcatgat tagcagttaa accaataagc tgaactcctc catataccaa   2047140
aattcctgcc aaaacagcta taataccatt tatttcagct caagatttca accaagccca   2047200
acggctctct ggatgacgtc ctgaaggcaa tttcgcaaat atcatatttg ttgatattgc   2047260
tgcaaaaaaa gagcaactga tatcatataa ggagctattg cgattccatt tacaggaact   2047320
tgatcattgt ctgtttttga aagattgagt ggatttgaca aaatctctgc atttttagat   2047380
tctgttgata ctgatttgag ttgatcacta gcattaccta gtccttgtcc taaagaagca   2047440
agtcctgtct gtaaatcttc caatccagaa gttaactttg ttccaccttc tgctagtttc   2047500
ccagatccat ctgccaattt attagctcta ttctctaatg gagaagcacc tgaaagtaac   2047560
tgactggatt tgtctgctaa ttgcccagat cctgattgta attaaccaac tcctgctgtc   2047620
aatctagaag atttttgtgt caaggtgttt gagcctgaaa ctagtttatc caaactacct   2047680
gtcaaggtgg catttttttc acttagttga cttgcgccct gagaaacttt atcaacacct   2047740
gtagtatatg cgtttacacc tgatgcaatc gactgactgg caggaactaa tttgctagta   2047800
acatctcctt gtatctctgt taatccactt gacaatccta tcaaagaagt agaagtaata   2047860
ggtgatactt gattagattg attttttaaa gtcgaaagat tagaagattg attttgtaag   2047920
ttttctaaac ttccctgtaa atcttgtact aaagctacaa ttgactgagc cgattgaata   2047980
ctatcagttg aattttgaga tacagaatca cttatctcag tttgttgctc acttgtcaat   2048040
gattgataag ctgctgtcga ttgaatattg gataatgtag ttgttttttc agataaatca   2048100
cttggtaaag tcactaccat atagtaatcg ccatcttcca atcccttctt tccttcctct   2048160
tcatctacaa aatgaaaatc caaggtttta ttttctttta aattggacac catgtctttt   2048220
cctattgcca tagtattacc attataggaa gcctctttat cattatttac aactgccaca   2048280
ggtaagtcag acaattgccc atatggatcc cacattgatg acaaaaatat gatattgtac   2048340
agatctggaa taagagaaat cccgatcatg acaataataa aggttggttt tttttaaatt   2048400
gctttccatt ctttaaactt agtttctcct tttttaaaca tattgtctaa aattttgata   2048460
taatagatta tacattaaaa aatctaaatt acaagataaa aaatctattt ttagacatat   2048520
agtctaattt gtttacaagg aggaaatatg caagaaagta acaaacgctt aaaaacaaag   2048580
cgaactattg aaaatgctat ggtacaatta ctgatggaac agccatttga taaaatttct   2048640
actgtcaaat tagtagaaaa agccggaatt agtcgttcca gcttctatac tcactataag   2048700
gataagtatg atatgattga gcactatcaa agcaagctat tccatacatt tgaatatatt   2048760
tttcaaaaac atgctcatca caaaagagac gctattttag aagtttttga atatctagag   2048820
tcagaaccac ttctggctgc ccttctttct gaaaatggga ctaaagaaat ccaaaatttc   2048880
ttacgaaata aacttcatat catgcttagt acagatttac aaaagcgatt tatgcaactg   2048940
aatctaaata ccactgaatt agaatatagt agcatctatc taactcatgc actttttggt   2049000
gtctgccaaa cttggattgc acatggaaaa aaagaaagtt ctcaagaaat aacagacttc   2049060
cttatgaaaa tgcttggtga tacaaattga tacaaaaaga ggaacacagc tgtgttccct   2049120
tttatctata ctccgccagt aggactcgaa cctacgacat catgattaac agtcatgcgc   2049180
tactaccaac tgagctatgg cggataaaat agtccgtacg ggattcgaac ccgtgttacc   2049240
gccgtgaaaa ggcggtgtct taaccccttg accaacggac cttctatctg tagcagatat   2049300
aaccattata tcaatttctt gctaattgtc aatcactttt gagatttttt ctctaaaata   2049360
tcttttaatt ttctaatttt taatcttgaa ataggacaac gatggtcttc atagaaaaca   2049420
atttctaagt tttttcgatc aatttctctg atattaccta tatttaccaa aaatgacttg   2049480
tgaggagaat aaaatcgctg agtatgtttg tccttttcct gaatatctgt catggtacca   2049540
taaaactctt ttgcaaaatt cttaccaata atgcgcaatt tatgagatac ccctgttgtt   2049600
tcaatataca aaatatcatg gtaaggaatt tttaaatcat ttcccttgta attgtagtcg   2049660
aaataatcta caacatcttc attttcaagt aacatactct tcgtgtagaa gatattttgc   2049720
tcaattctct tcttaaacat ctcatcattg atatccttat caacaaaatc tagggctgat   2049780
acctggtatt tataggttag agtcgcaaac tctgatcgac tagtgataaa gacgataata   2049840
gcgtaaggat tgtaatgacg aatgagctga gccacttcaa atcccttttt ctcaattcca   2049900
tgaatatcga tatctaggaa ataaagctga tttacttcat cattttcaat gtattcttca   2049960
aattcacgga cttttcccgt tgtcttgtat gatattggaa tattcgattc tttcgaaatt   2050020
tcatccaata ttctctctag tctcacttga tgttcaataa catcttctaa aattaaaact   2050080
ttcattcaaa ttccctctta aatctaatga tttgtctaaa tgtactgcct tccatctctg   2050140
tttctaaaat aatattgttg tacttatcta gtagttcttt cacattattt aatccgactc   2050200
cgcgatttct tcccttagtg gagaatccta aggcaaatag atctcctgaa ggagtcatcg   2050260
tcattttaca tgaattctga atcacaataa ctgtttcagt ttccatctta ataactgcta   2050320
cttccatctg ctttttatag ctatcagccg atccttcgac agcattattc aataaaacgc   2050380
tcatgatacg aaccaaatcc aatagttcaa ttggaagctt ggtaatcgta tcttttactt   2050440
ccagtgtaaa ctctacacca ttatttcgag catagacaat tgactgagca accaaacttc   2050500
gtaaagctga gtcttctatg ttgttcaaat caaagtaagt gtacttatct gaacgcaatt   2050560
tatgatttgc tttgactaaa acttcattgt aaattctgtc aatttcctgt aaattaccac   2050620
tgtcaattgc catctgcatg ctgacaagca ttccagcata atcatgtcga aaaccacgga   2050680
tttcattata cagaccaaca atttcatctg tgtaattctg taaatgtttc tgttcaaatt   2050740
tcttctgctt caaagcaatc tctttctcca tttgaacttt atgagaattc attgcaaaga   2050800
aggtcaaaag gagagagata aagacaatag atgacaaaat acttccaaaa ctattcaaat   2050860
gtttaatcgt acttaccata tctgaaacga aagatacaat atgtagcaat agtaaagcaa   2050920
aaaatacttt tttcaagaaa ggataaaggt agtccttgtc aaaataggct agttccaaat   2050980
ggaaatagta aatgattttt aatgtaacaa aataggttaa caccgtcaca acgaaaaaga   2051040
atgggaaatg atattgtaaa acaaaattat ctcctgttat agaggagaaa attacggaca   2051100
gaaagttatg agtgctctca tataaaagag atagtagtaa acttaggaat agtcctctat   2051160
ccctctcata ctgtttcatc catcgaaaat aggaatataa gcccaaagga aataaaaatc   2051220
tttcaatccc tattttatct aaatatagaa gataaaagga aaattcaagt actatttcag   2051280
ttagtaatgt ataagcacca aaaacgtata attcttttct atttattcga cctttacaaa   2051340
ttaaacggta actgtgacta ataattaaaa aatgaacaat aactgtccca aatccaagta   2051400
aatccattac tctttctcct tatttcatta cttttttcgt aggaaaagaa aatcaaggat   2051460
gattcttgaa atcctcatct ccccaccttt aatcttttgt aagtcttttt ccttcaaagc   2051520
tacaaactgt tccaatttaa ctgtgttttt cataataaaa tctcctaaaa tgttttttct   2051580
tgtaagctaa cttacaaaaa ccattataca aaatggaatt tcgttttaga taaaattctc   2051640
tcaactgtca tttttttctc ccaaagtgta cttttttaag aaaaaagccg ggaaaattcc   2051700
cagctttgct attatattga tcccagcagg attcgaacct gcgaccgttc gcttagaagg   2051760
cgaatgctct atccagctga gctatgagac ctaatacaat tattctacca aaaattcaat   2051820
taaaagtcaa ttttctattt atggtagggg aatccctgct gaatcgtaaa agcgcgatag   2051880
atttgttcaa caagaactag tctcattaac tgatggggta aggttaggcg accaaaactg   2051940
acagaaagat tggctctatt ttttacagat gatgataatc ctaaacttcc cccaataata   2052000
aaagtaagag tagaaaatcc ttttatagaa gtttcttcta actgcttact aaattcttct   2052060
gagaagaaag ttttcccttc aatggctaac acaataacga aatcacggtc agcaattttt   2052120
gataaaattc tctgaccttc tatttctaaa atcttttgat tttctgattc actggcctta   2052180
tctggtgttt tttcatctga taactcaatc atttcaaact tagcaaatct agaaattcgt   2052240
tttgaatact ctgcgatacc atcttttaaa tacttttctt tcagtttccc aactgttaca   2052300
actttaattt tcatgactct attctaacat attctctatt ttttcacatc ttattcacaa   2052360
aataaaaaat agatttcaat taagaaaatc acaatttcaa aagagttatc cacagtttgt   2052420
gtaaaacttt tgtgtttaag ttataattaa gctagtcagt ttatactttc agtaattcaa   2052480
acatatggag gcaaatatga aacatctaaa aacattttac aaaaaatggt ttcaattatt   2052540
agtcgttatc gtcattagct tttttagtgg agccttgggt agtttttcaa taactcaact   2052600
aactcaaaaa agtagtgtaa acaactctaa caacaatagt actattacac aaactgccta   2052660
taagaacgaa aattcaacaa cacaggctgt taacaaagta aaagatgctg ttgtttctgt   2052720
tattacttat tcggcaaaca gacaaaatag cgtatttggc aatgatgata ctgacacaga   2052780
ttctcagcga atctctagtg aaggatctgg agttatttat aaaaagaatg ataaagaagc   2052840
ttacatcgtc accaacaatc acgttattaa tggcgccagc aaagtagata ttcgattgtc   2052900
agatgggact aaagtacctg gagaaattgt cggagctgac actttctctg atattgctgt   2052960
cgtcaaaatc tcttcagaaa aagtgacaac agtagctgag tttggtgatt ctagtaagtt   2053020
aactgtagga gaaactgcta ttgccatcgg tagcccgtta ggttctgaat atgcaaatac   2053080
tgtcactcaa ggtatcgtat ccagtctcaa tagaaatgta tccttaaaat cggaagatgg   2053140
acaagctatt tctacaaaag ccatccaaac tgatactgct attaacccag gtaactctgg   2053200
cggcccactg atcaatattc aagggcaggt tatcggaatt acctcaagta aaattgctac   2053260
aaatggagga acatctgtag aaggtcttgg tttcgcaatt cctgcaaatg atgctatcaa   2053320
tattattgaa cagttagaaa aaaacggaaa agtgacgcgt ccagctttgg gaatccagat   2053380
ggttaattta tctaatgtga gtacaagcga catcagaaga ctcaatattc caagtaatgt   2053440
tacatctggt gtaattgttc gttcggtaca aagtaatatg cctgccaatg gtcaccttga   2053500
aaaatacgat gtaattacaa aagtagatga caaagagatt gcttcatcaa cagacttaca   2053560
aagtgctctt tacaaccatt ctatcggaga caccattaag ataacctact atcgtaacgg   2053620
gaaagaagaa actacctcta tcaaacttaa caagagttca ggtgatttag aatcttaatt   2053680
gacatctatg taaagaaagc tttacataag agaaaagatg tgttagtgta gaatcatgga   2053740
aaaatttgaa atgatttcta tcacagatat acaaaaaaat ccctatcaac cccgaaaaga   2053800
atttgataga gaaaaactag atgaactagc acagtctatc aaagaaaatg gggtcattca   2053860
accgattatt gttcgtcaat ctcctgttat tggttatgaa atccttgcag gagagagacg   2053920
ctatcgggct tcacttttag ctggtctacg gtctatccca gctgttgtta aacagatttc   2053980
agaccaagag atgatggtcc agtccattat tgaaaattta cagagagaaa atttaaaccc   2054040
aatagaagaa gcacgcgcct atgaatctct cgtagagaaa ggattcaccc atgctgaaat   2054100
tgcagataag atgggcaagt ctcgtccata tatcagcaac tccattcgtt tactttcctt   2054160
gccagaacag attctttcag aagtagaaaa tggcaaacta tcacaagccc atgcgcgttc   2054220
cctagttggg ttaaataagg aacaacaaga ctatttcttt caacggatta tagaagaaga   2054280
tatttctgta aggaaattag aagctcttct gacagagaaa aaacaaaaga aacagcaaaa   2054340
aactaatcat ttcatacaaa atgaagaaaa acagttaaga aaactactcg gattagatgt   2054400
agaaattaaa ctatctaaaa aagacagtgg aaaaatcatt atttcttttt caaatcaaga   2054460
agaatatagt agaattatca acagcctgaa ataaggctgt tcttttattt ttttatctca   2054520
caaggttatc cactatgttt ttcgataaaa agcttaataa atcaataatt tcttctttta   2054580
tccccaacct gtggataaag tttggtaaca ttgtggatta tttttcacag cttgtggaaa   2054640
attcttgcta tctatggtaa aatatctcta gtattaaact tttaaatagt aaaggaggag   2054700
aaaggattga aagaaaaaca attttggaat cgtatattag aatttgcaca agaaagactg   2054760
actcgatcca tgtatgattt ctatgctatt caagctgaac tcatcaaggt agaggaaaat   2054820
gttgccacta tatttctacc tcgctctgaa atggaaatgg tctgggaaaa acaactaaaa   2054880
gatattattg tagtagctgg ttttgaaatt tatgacgctg aaataactcc ccactatatt   2054940
ttcaccaaac ctcaagatac gactagctca caagttgaag aagctacaaa tttaactctt   2055000
tataactata gtccaaagtt agtatctatt ccttattcag atacgggatt aaaagaaaag   2055060
tatacctttg ataactttat tcaaggggat ggaaatgttt gggctgtatc agccgcttta   2055120
gctgtctctg aagatttggc tctgacctat aaccctcttt ttatctatgg aggaccaggc   2055180
cttggtaaga ctcacttatt aaacgctatt ggaaatgaaa ttctaaaaaa tattcctaat   2055240
gcgcgtgtta aatatatccc tgccgaaagc tttattaatg actttcttga tcacctaaga   2055300
cttggggaaa tggaaaagtt taaaaagacc tatcgtagtc ttgatctttt gttaatcgat   2055360
gatatccagt cactcagcgg aaaaaaagtc gcaactcagg aagaattttt caataccttt   2055420
aacgcccttc atgacaagca aaaacagatt gtcctaacga gtgatcgtag tccaaaacat   2055480
ctagaagggc tcgaggagag gcttgtcacg cgttttagtt ggggattgac acaaactatc   2055540
accccccctg actttgaaac acgtattgcc attttacaaa gtaagacgga acatttaggc   2055600
tacaatttcc aaagtgatac tctagaatac ctagctgggc aatttgattc aaatgttcga   2055660
gatcttgagg gagccatcaa cgacatcact ttaattgcca gagtaaaaaa aatcaaggat   2055720
atcactattg atattgctgc agaagccatt agagcccgca aacaagatgt tagccaaatg   2055780
ctcgtcatcc caattgataa aatccaaact gaagttggta acttttatgg tgttagtatc   2055840
aaagaaatga agggaagtag acgccttcaa aatattgttt tggcccgtca agtagccatg   2055900
tatttatcta gagaactaac agataatagt cttccaaaaa ttgggaagga atttggggga   2055960
aaagatcata ccacagtcat tcatgcccat gccaaaataa aatctttgat tgatcaagac   2056020
gataatttac gtttagaaat tgaatcaatc aaaaagaaaa tcaaataatt tgtggataac   2056080
ttttagtttt ttatcttttt tatccacatt ttttaaacaa gctaaaaaac ttgatatgac   2056140
ttgtttaaag gctgttttcc acagatttca cagactctat tattactatt atctttctaa   2056200
tactaaaaat aaataaagga gaatccatga ttcatttttc aattaataaa aatttatttc   2056260
tacaagcatt aaatactact aagagagcta ttagttctaa aaatgccatt cctattttat   2056320
caacagtaaa aattgacgtg accaatgaag gtattacttt aattggttca aatggtcaaa   2056380
tttcaattga aaattttatt tctcaaaaaa atgaagatgc tggtttgtta attacttctt   2056440
taggttcgat ccttcttgaa gcttctttct ttatcaatgt agtatctagt ttacctgatg   2056500
taactcttga ttttaaagaa attgaacaaa atcaaattgt tttaaccagt ggcaaatcag   2056560
aaattaccct aaaaggaaaa gatagcgaac aatatccacg aatccaagaa atttcagcaa   2056620
gcactccttt aatacttgaa acaaaattac tcaagaaaat tattaatgaa acagcctttg   2056680
ctgcaagtac acaagagagt cgtccgattt taacaggtgt ccacttcgta ttgagtcaac   2056740
acaaagagtt aaaaacagtt gcaacagact ctcatcgcct aagccagaaa aaattgactc   2056800
ttgaaaaaaa tagtgatgat tttgatgtcg taattcctag ccgttctcta cgcgaatttt   2056860
cagcggtatt tacagatgat atcgaaactg tagagatttt ctttgccaat aaccaaatcc   2056920
tctttagaag cgaaaatatt agcttctata ctcgtctcct agaaggaaac tatcctgata   2056980
cagatcgctt gattccaaca gactttaaca ctactattac ttttaatgtg gtaaacttac   2057040
gccagtcaat ggagcgtgcc cgtcttttat caagtgcgac tcaaaatggt actgtgaaac   2057100
ttgaaattaa ggatggggtt gttagcgccc atgttcactc tccagaagtt ggtaaagtaa   2057160
acgaagaaat cgatactgat caggttactg gtgaagattt gaccattagt ttcaacccaa   2057220
cttacttgat tgattctctt aaagctttaa atagcgaaaa ggtgactatt agctttatct   2057280
cagctgttcg tccatttact cttgtgccag cagatactga cgaagacttc atgcagctca   2057340
ttacaccagt tcgtacaaat taagtgaaag aggttgagcc tggctcgcct cttttatgat   2057400
ataatcgaaa aagaaaagga gagtagtatg tatcaagttg gaaattttgt tgagatgaaa   2057460
aaatcacacg cttgtacaat caagtcgact ggtaaaaagg ctaatcgttg ggaaattaca   2057520
cgtgtaggag cagatatcaa aataaaatgt agtaattgtg agcatgttgt catgatgggg   2057580
cgatatgatt ttgagcgaaa aatgaataaa attattgact gagaaccctt agttagaggg   2057640
ttagcacttt atcccttttt gtgttataat attagggatt gaaatgaaaa cggagaatga   2057700
gaaatatggc tttgacagca ggtatcgttg gtttgccaaa cgttggtaaa tcaacactat   2057760
ttaatgcaat tacaaaagca ggagcagagg cagcaaacta cccatttgcg acgattgatc   2057820
caaatgttgg aatggtggaa gttccagatg aacgcctaca aaaactaact gaaatgataa   2057880
ctcctaaaaa gacagttccc acaacatttg aatttacaga tattgcaggg attgtaaaag   2057940
gagcttcaaa aggagagggg ctagggaata aattcttggc caatattcgt gaagtagatg   2058000
cgattgttca cgtagttcgt gcttttgatg atgaaaatgt aatgcgcgag caaggacgtg   2058060
aagacgcctt tgtagatcca cttgcagata ttgataccat taatctggaa ttgattcttg   2058120
ctgacttaga atcagtgaac aaacgatatg cgcgtgtaga aaagatggca cgtacgcaaa   2058180
aagataaaga atcagtagca gaattcaatg ttcttcaaaa gattaaacca gtcctagaag   2058240
acgggaaatc agctcgtacc attgaattta cagatgagga acaaaaggtt gtcaaaggtc   2058300
ttttcctttt gacgactaaa ccagttcttt atgtagctaa tgtggacgag gatgtggttt   2058360
cagaacctga ctctatcgac tatgtcaaac aaattcgtga atttgcagcg acagaaaatg   2058420
ctgaagtagt cgttatttct gcgcgtgctg aggaagaaat ttctgaattg aatgatgaag   2058480
ataaaaaaga gtttcttgaa gccattggtt tgacagaatc aggtgtagat aagttgacgc   2058540
gtgcagctta ccacttgctt ggattgggaa cttacttcac agctggtgaa aaagaagttc   2058600
gcgcttggac tttcaaacgt ggtatgaagg ctcctcaagc agctggtatt atccactcag   2058660
actttgaaaa aggctttatt cgtgcagtaa ccatgtcata tgaagatcta gtgaaatacg   2058720
gatctgaaaa ggccgtaaaa gaagctggac gcttgcgtga agaaggaaaa gaatatatcg   2058780
ttcaagatgg cgatatcatg gaattccgct ttaatgtcta aaaattaata aatggtgtca   2058840
attaggttgg aaaaaaattc caaccctttt ggcttttgaa aggaaaaata aatgaccaaa   2058900
ttacttgtag gcttgggaaa tccaggggat aaatattttg aaacaaaaca caatgttggt   2058960
tttatgttga ttgatcaact agcgaagaaa cagaatgtca cttttacaca cgataagata   2059020
tttcaagctg acctagcatc ctttttccta aatggagaaa aaatttatct ggttaaacca   2059080
acgaccttta tgaatgaaag tggaaaagca gttcatgctt tattaactta ctatggtttg   2059140
gatattgacg atttacttat catttacgat gatcttgaca tggaagttgg gaaaattcgt   2059200
ttaagagcaa aaggctcagc aggtggtcat aatggtatca agtctattat tcaacatata   2059260
ggaactcagg tctttaaccg tgttaagatt ggaattggaa gacctaaaaa tggtatgtca   2059320
gttgttcatc atgttttgag taagtttgac agggatgatt atatcggtat tttacagtct   2059380
gttgacaaag ttgacgattc tgtaaactac tatttacaag agaaaaattt tgagaaaaca   2059440
atgcagaggt ataacggata aatggtgacc ttattagatt tattctcaga aaatgatcag   2059500
attaaaaaat ggcatcaaaa tttaacagat aagaaaagac aactaatact tggtttatca   2059560
acatctacta aggctcttgc aattgcaagc agtttagaaa aagaagatag gattgtgtta   2059620
ttgacgtcaa cttatggaga agcagaagga cttgttagtg atcttatttc tatcttgggt   2059680
gaggaactcg tctatccatt tttggtagat gatgctccta tggtggagtt tttgatgtct   2059740
tcacaggaaa aaattatttc acgggttgaa gccttgcgtt ttttgactga ttcatctaag   2059800
aaagggattt tagtttgtaa tatcgcagca agtcgattga ttttaccgtc tcccaatgca   2059860
ttcaaagata gtattgtaaa aatctcagtt ggtgaagaat atgatcaaca cgcgtttatc   2059920
catcagttaa aggaaaatgg ctatcgaaaa gttactcaag tacaaactca gggcgaattt   2059980
agtcttcgag gagatatttt agatattttt gaaatatccc agttagaacc ttgtcgaatt   2060040
gagttttttg gtgatgaaat tgatggtatc aggtcatttg aagtagaaac acaattatcg   2060100
aaagaaaata agacagaact cactatcttt ccagctagtg atatgctttt gagagaaaag   2060160
gattatcaac gaggacagtc agctttagaa aaacaaattt caaaaacttt atcacctatt   2060220
ttgaaatcat acctagaaga aattctttca agttttcacc aaaaacaaag tcatgcagac   2060280
tctcggaagt ttttatcttt gtgctatgat aagacatgga ctgtctttga ttatattgaa   2060340
aaagatactc caatattctt tgatgattat caaaaattga tgaatcagta tgaagtcttt   2060400
gaaagagact tagcgcagta ctttacagaa gaattacaga atagtaaagc attttctgat   2060460
atgcagtatt tttctgatat tgaacaaatc tataaaaaac aaagtccagt gacctttttc   2060520
tctaatcttc aaaagggttt aggaaatctc aaatttgaca aaatttatca attcaatcaa   2060580
tatcctatgc aggaattttt caatcagttt tcttttctaa aagaagaaat tgaacgatat   2060640
aaaaaaatgg attacaccat tattctgcag tctagcaatt caatgggaag taaaacattg   2060700
gaggatatgt tagaggaata tcagattaaa ttggattcta gagataagac aaatatctgt   2060760
aaagaatctg taaacttaat agagggtaat ctcagacatg gttttcattt tgtagatgaa   2060820
aagattttat tgataactga acatgagatt tttcaaaaga aattaaagcg tcgttttcga   2060880
agacaacatg tttcaaatgc agagagatta aaagattaca atgaacttga aaaaggggac   2060940
tatgttgtcc atcatatcca tgggattggt caatatctag gaattgaaac cattgaaatc   2061000
aagggaattc atcgcgatta tgtcagtgtc caataccaaa atggtgatca aatttctatc   2061060
cccgtggaac agattcatct actgtccaaa tatatttcaa gtgatggtaa agctccaaaa   2061120
ctcaataaat taaatgacgg tcattttaaa aaggccaagc aaaaggttaa gaaccaggta   2061180
gaggatatag ctgatgattt aatcaaactc tactctgaac gtagtcagtt gaagggtttt   2061240
gctttctcag ctgatgatga tgatcaagat gcctttgatg atgctttccc ttatgttgaa   2061300
acggatgatc aacttcgtag tattgaggaa atcaagaggg atatgcaggc ttctcagcca   2061360
atggatcgac ttttagttgg ggatgttggt tttggaaaga ctgaagttgc tatgcgtgca   2061420
gcctttaaag cagtcaatga tcacaaacag gttgtcattc tagttccgac gacggtttta   2061480
gcgcaacagc actatacgaa ttttaaggaa cgattccaaa attttgcagt taatattgat   2061540
gtgttgagtc gctttagaag taaaaaagag cagactgcaa cacttgaaaa attgaaaaac   2061600
ggtcaagtcg atattttgat tggaacacat cgtgttttgt caaaagatgt tgtgtttgct   2061660
gatttgggct tgatgattat tgatgaggaa cagcgatttg gtgtcaagca taaggaaact   2061720
ttgaaagaac tgaagaaaca agtggatgtc ctaaccttga ccgctacgcc aatccctcgt   2061780
accctccata tgtctatgct gggaatcaga gatttatctg ttattgaaac tccgccgact   2061840
aatcgctatc ctgttcagac ctatgttttg gaaaagaatg atagtgtcat tcgtgatgct   2061900
gtcttgcgtg aaatggagcg tggaggtcaa gtttattatc tttacaacaa agttgacaca   2061960
attgttcaga aggtttcaga attacaggag ttgattccgg aggcttcgat tggatatgtt   2062020
catggtcgaa tgagtgaagt ccagttggaa aatactctat tagactttat tgagggacaa   2062080
tacgatatct tggtgacgac tactattatt gagacagggg tggacattcc aaatgctaat   2062140
actttattta ttgaaaatgc ggaccatatg ggcttgtcaa ccttatatca gttaagagga   2062200
agagtcggtc gtagtaatcg tattgcttat gcttatctca tgtatcgtcc agaaaaatca   2062260
atcagtgaag tctctgaaaa gagattagaa gcgattaaag gatttacaga attgggctct   2062320
ggctttaaga ttgcaatgcg agatctttcg attcgtggag caggaaatct tttaggaaaa   2062380
tcccagtctg gtttcattga ttctgttggt tttgaattgt attcgcagtt attagaggaa   2062440
gctattgcta aacgaaacgg taatgctaac gctaacacaa gaaccaaagg gaatgctgag   2062500
ttgattttgc aaattgatgc ctatcttcct gatacttata tttctgatca acgacataag   2062560
attgaaattt acaagaaaat tcgtcaaatt gacaaccgtg tcaattatga agagttacaa   2062620
gaggagttga tagaccgttt tggagaatac ccagatgtag tagcctatct gttagagatt   2062680
ggtttggtca aatcatactt ggacaaggtc tttgttcaac gtgtggaaag aaaagataat   2062740
aaaattacaa ttcaatttga aaaagtcact caacgactgt ttttagctca agattatttt   2062800
aaagctttat ccgtaacgaa cttaaaagca ggcatcgctg agaataaggg attaatggag   2062860
cttgtatttg atgtccaaaa taagaaagat tatgaaattt tagaaggttt gctgattttt   2062920
ggagaaagtt tattagagat aaaagagtct aaggaagaaa attccatttg atatttttct   2062980
tctataaaat agataaaaat ggtacaataa taaattgagg taataaggat gagattagat   2063040
aaatatttaa aagtatcgcg aattatcaag cgtcgtacag tcgcaaagga agtagcagat   2063100
aaaggtagaa tcaaggttaa tggaatcttg gccaaaagtt caacggactt gaaagttaat   2063160
gaccaagttg aaattcgctt tggcaataag ttgctgcttg taaaagtact agagatgaaa   2063220
gatagtacaa aaaaagaaga tgcagcagga atgtatgaaa ttatcagtga aacacgggta   2063280
gaagaaaatg tctaaaaata ttgtacaatt gaataattct tttattcaaa atgaatacca   2063340
acgtcgtcgc tacctgatga aagaacgaca aaaacggaat cgttttatgg gaggggtatt   2063400
gattttgatt atgctattat ttatcttgcc aacttttaat ttagcgcaga gttatcagca   2063460
attactccaa agacgtcagc aattagcaga cttgcaaact cagtatcaaa ctttgagtga   2063520
tgaaaaggat aaggagacag catttgctac caagttgaaa gatgaagatt atgctgctaa   2063580
atatacacga gcgaagtact attattctaa gtcgagggaa aaagtttata cgattcctga   2063640
cttgcttcaa aggtgataaa atggaaaatt tattagacgt aatagagcaa tttttgagtt   2063700
tgtcagatga aaagctggaa gaattggctg ataaaaatca attattgcgt ttacaagaag   2063760
aaaaggaaag gaagaatgcg taaattctta attattttgt tgctaccaag ttttttgacc   2063820
atttcaaaag tcgttagcac agaaaaagaa gtcgtctata cttcgaaaga aatttattac   2063880
ctttcacaat ctgactttgg tatttatttt agagaaaaat taagttctcc catggtttat   2063940
ggagaggttc ctgtttatgc gaatgaagat ttagtagtgg aatctgggaa attgactccc   2064000
aaaacaagtt ttcaaataac cgagtggcgc ttaaataaac aaggaattcc agtatttaag   2064060
ctatcaaatc atcaatttat agctgcggac aaacgatttt tatatgatca atcagaggta   2064120
actccaacaa taaaaaaagt atggttagaa tctgacttta aactgtacaa tagtccttat   2064180
gatttaaaag aagtgaaatc atccttatca gcttattcgc aagtatcaat cgacaagacc   2064240
atgtttgtag aaggaagaga atttctacat attgatcagg ctggatgggt agctaaagaa   2064300
tcaacttctg aagaagataa tcggatgagt aaagttcaag aaatgttatc tgaaaaatat   2064360
cagaaagatt ctttctctat ttatgttaag caactgacta ctggaaaaga agctggtatc   2064420
aatcaagatg aaaagatgta tgcagccagc gttttgaaac tctcttatct ctattatacg   2064480
caagaaaaaa taaatgaggg tctttatcag ttagatacga ctgtaaaata cgtatctgca   2064540
gtcaatgatt ttccaggttc ttataaacca gagggaagtg gtagtcttcc taaaaaagaa   2064600
gataataaag aatattcttt aaaggattta attacgaaag tatcaaaaga atctgataat   2064660
gtagctcata atctattggg atattacatt tcaaaccaat ctgatgccac attcaaatcc   2064720
aagatgtctg ccattatggg agatgattgg gatccaaaag aaaaattgat ttcttctaag   2064780
atggccggga agtttatgga agctatttat aatcaaaatg gatttgtgct agagtctttg   2064840
actaaaacag attttgatag tcagcgaatt gccaaaggtg tttctgttaa agtagctcat   2064900
aaaattggag atgcggatga atttaagcat gatacgggtg ttgtctatgc agattctcca   2064960
tttattcttt ctattttcac taagaattct gattatgata cgatttctaa gatagccaag   2065020
gatgtttatg aggttctaaa atgagggaac cagatttttt aaatcatttt ctcaagaagg   2065080
gatatttcaa aaagcatgct aaggcggttc tagctctttc tggtggatta gattccatgt   2065140
ttctatttaa ggtattgtct acttatcaaa aagagttaga gattgaattg attctagctc   2065200
atgtgaatca taagcagaga attgaatcag attgggaaga aaaggaatta aggaagttgg   2065260
ctgctgaagc agagcttcct atttatatca gcaatttttc aggagaattt tcagaagcgc   2065320
gtgcacgaaa ttttcgttat gatttttttc aagaggtcat gaaaaagaca ggtgcgacag   2065380
ctttagtcac tgcccaccat gctgatgatc aggtggaaac gatttttatg cgcttgattc   2065440
gaggaactcg cttgcgctat ctatcaggaa ttaaggagaa gcaagtagtc ggagagatag   2065500
aaatcattcg tcccttcttg cattttcaga aaaaagactt tccatcaatt tttcactttg   2065560
aagatacatc aaatcaggag aatcattatt ttcgaaatcg tattcgaaat tcttacttac   2065620
cagaattgga aaaagaaaat cctcgattta gggatgcaat cttaggcatt ggcaatgaaa   2065680
ttttagatta tgatttggca atagctgaat tatctaacaa tattaatgtg gaagatttac   2065740
agcagttatt ttcttactct gagtctacac aaagagtttt acttcaaact tatctgaatc   2065800
gttttccaga tttgaatctt acaaaagctc agtttgctga agttcagcag attttaaaat   2065860
ctaaaagcca gtatcgtcat ccgattaaaa atggctatga attgataaaa gagtaccaac   2065920
agtttcagat ttgtaaaatc agtccgcagg ctgatgaaaa ggaagatgaa cttgtgttac   2065980
actatcaaaa tcaggtagct tatcaaggat atttattttc ttttggactt ccattagaag   2066040
gtgaattaat tcaacaaata cctgtttcac gtgaaacatc catacacatt cgtcatcgaa   2066100
aaacaggaga tgttttgatt aaaaatgggc atagaaaaaa actcagacgt ttatttattg   2066160
atttgaaaat ccctatggaa aagagaaact ctgctcttat tattgagcaa tttggtgaaa   2066220
ttgtctcaat tttgggaatt gcgaccaata atttgagtaa aaaaacgaaa aatgatataa   2066280
tgaacactgt actttatata gaaaaaatag ataggtaaaa aatgttagaa aacgatatta   2066340
aaaaagtcct cgtttcacac gatgaaatta cagaagcagc taaaaaacta ggtgctcaat   2066400
taactaaaga ctatgcagga aaaaatccaa tcttagttgg gattttaaaa ggatctattc   2066460
cttttatggc tgaattggtc aaacatattg atacacatat tgaaatggac ttcatgatgg   2066520
tttctagcta ccatggtgga acagcaagta gtggtgttat caatattaaa caagatgtga   2066580
ctcaagatat caaaggaaga catgttctat ttgtagaaga tatcattgat acaggtcaaa   2066640
ctttgaagaa tttgcgagat atgtttaaag aaagagaagc agcttctgtt aaaattgcaa   2066700
ccttgttgga taaaccagaa ggacgtgttg tagaaattga ggcagactat acttgcttta   2066760
ctatcccaaa tgagtttgta gtaggttatg gtttagacta caaagaaaat tatcgtaatc   2066820
ttccttatat tggagtattg aaagaggaag tgtattcaaa ttagaaagaa taatctttaa   2066880
tgaaaaaaca aaataatggt ttaattaaaa atccttttct atggttatta tttatctttt   2066940
tccttgtgac aggattccag tatttctatt ctgggaataa ctcaggagga agtcagcaaa   2067000
tcaactatac tgagttggta caagaaatta ccgatggtaa tgtaaaagaa ttaacttacc   2067060
aaccaaatgg tagtgttatc gaagtttctg gtgtctataa aaatcctaaa acaagtaaag   2067120
aagaaacagg tattcagttt ttcacgccat ctgttactaa ggtagagaaa tttaccagca   2067180
ctattcttcc tgcagatact accgtatcag aattgcaaaa acttgctact gaccataaag   2067240
cagaagtaac tgttaagcat gaaagttcaa gtggtatatg gattaatcta ctcgtatcca   2067300
ttgtgccatt tggaattcta ttcttcttcc tattctctat gatgggaaat atgggaggag   2067360
gcaatggccg taatccaatg agttttggac gtagtaaggc taaagcagca aataaagaag   2067420
atattaaagt aagattttca gatgttgctg gagctgagga agaaaaacaa gaactagttg   2067480
aagttgttga gttcttaaaa gatccaaaac gattcacaaa acttggagcc cgtattccag   2067540
caggtgttct tttggaggga cctccgggga caggtaaaac tttgcttgct aaggcagtcg   2067600
ctggagaagc aggtgttcca ttctttagta tctcaggttc tgactttgta gaaatgtttg   2067660
tcggagttgg agctagtcgt gttcgctctc tttttgagga tgccaaaaaa gcagcaccag   2067720
ctatcatctt tatcgatgaa attgatgctg ttggacgtca acgtggagtc ggtctcggcg   2067780
gaggtaatga cgaacgtgaa caaaccttga accaactttt gattgagatg gatggttttg   2067840
agggaaatga agggattatc gtcatcgctg cgacaaaccg ttcagatgta cttgaccctg   2067900
cccttttgcg tccaggacgt tttgatagaa aagtattggt tggtcgtcct gatgttaaag   2067960
gtcgtgaagc aatcttgaaa gttcacgcta agaataagcc tttagcagaa gatgttgatt   2068020
tgaaattagt ggctcaacaa actccaggct ttgttggtgc tgatttagag aatgtcttga   2068080
atgaagcagc tttagttgct gctcgtcgca ataaatcgat aattgatgct tcagatattg   2068140
atgaagcaga agatagagtt attgctggac cttctaagaa agataagaca gtttcacaaa   2068200
aagaacgaga attggttgct taccatgagg caggacatac cattgttggt ctagtcttgt   2068260
cgaatgctcg cgttgtccat aaggttacaa ttgtaccacg cggccgtgca ggcggataca   2068320
tgattgcact tcctaaagag gatcaaatgc ttctatctaa agaagatatg aaagagcaat   2068380
tggctggctt aatgggtgga cgtgtagctg aagaaattat ctttaatgtc caaaccacag   2068440
gagcttcaaa cgactttgaa caagcgacac aaatggcacg tgcaatggtt acagagtacg   2068500
gtatgagtga aaaacttggc ccagtacaat atgaaggaaa ccatgctatg cttggtgcac   2068560
agagtcctca aaaatcaatt tcagaacaaa cagcttatga aattgatgaa gaggttcgtt   2068620
cattattaaa tgaggcacga aataaagctg ctgaaattat tcagtcaaat cgtgaaactc   2068680
acaagttaat tgcagaagca ttattgaaat acgaaacatt ggatagtaca caaattaaag   2068740
ctctttacga aacaggaaag atgcctgaag cagtagaaga ggaatctcat gcactatcct   2068800
atgatgaagt aaagtcaaaa atgaatgacg aaaaataacc ctgagagagg ctggagcctc   2068860
tcttttttgt gcagtttagg agctaaaggg aacagaatgg agaaaatgga acaaatgtgt   2068920
tttctaatct gttagactgt atctagaaag gggaaaatta tgattaaaga attgtatgaa   2068980
gaagtccaag ggactgtgta taagtgtaga aatgaatatt accttcattt atgggaattg   2069040
tcggattggg agcaagaagg catgctctgc ttacatgaat tgattagtag agaagaagga   2069100
ctggtagacg atattccacg tttaaggaaa tatttcaaga ccaagtttcg aaatcgaatt   2069160
ttagactata tccgtaaaca ggaaagtcag aagcgtagat acgataaaga accctatgaa   2069220
gaagtgggtg agatcagtca tcgtataagt gaggggggtc tctggctaga tgattattat   2069280
ctctttcatg aaacactaag agattataga aacaaacaaa gtaaagagaa acaagaagaa   2069340
ctagaacgcg tcttaagcaa tgaacgattt cgagggcgtc aaagagtatt aagagactta   2069400
cgcattgtgt ttaaggagtt tactatccgt acccactagt aagtcatgca aaaaaaatga   2069460
aaaaaattag aaaaagtagt tgacaaagtt tgaaaaggct gtataatagt aagagttgaa   2069520
aataacaact caggtccgtt ggtcaagggg ttaagacacc gccttttcac ggcggtaaca   2069580
cgggttcgaa tcccgtacgg actatggtat gttgcgtcag gaccacttga tgaaaaaaag   2069640
tttaaaaaaa cttaaaaatc ttcaaaaaag tgttgacaag cgaaagcagt tgtgatatac   2069700
taatatagtt gtcgcttgag agaagcaagt gacaaagacc tttgaaaact gaacaagacg   2069760
aaccaatgtg cagggcgcta caacgtaagt tgtagtactg aacaatgaaa aaaacaataa   2069820
atctgtcagt gacagaaatg agtaagaact caaacttttt aatgagagtt tgatcctggc   2069880
tcaggacgaa cgctggcggc gtgcctaata catgcaagta gaacgctgaa ggaggagctt   2069940
gcttctctgg atgagttgcg aacgggtgag taacgcgtag gtaacctgcc tggtagcggg   2070000
ggataactat tggaaacgat agctaatacc gcataagagt agatgttgca tgacatttgc   2070060
ttaaaaggtg cacttgcatc actaccagat ggacctgcgt tgtattagct agttggtggg   2070120
gtaacggctc accaaggcga cgatacatag ccgacctgag agggtgatcg gccacactgg   2070180
gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc ggcaatggac   2070240
ggaagtctga ccgagcaacg ccgcgtgagt gaagaaggtt ttcggatcgt aaagctctgt   2070300
tgtaagagaa gaacgagtgt gagagtggaa agttcacact gtgacggtat cttaccagaa   2070360
agggacggct aactacgtgc cagcagccgc ggtaatacgt aggtcccgag cgttgtccgg   2070420
atttattggg cgtaaagcga gcgcaggcgg ttagataagt ctgaagttaa aggctgtggc   2070480
ttaaccatag taggctttgg aaactgttta acttgagtgc aagaggggag agtggaattc   2070540
catgtgtagc ggtgaaatgc gtagatatat ggaggaacac cggtggcgaa agcggctctc   2070600
tggcttgtaa ctgacgctga ggctcgaaag cgtggggagc aaacaggatt agataccctg   2070660
gtagtccacg ctgtaaacga tgagtgctag gtgttagacc ctttccgggg tttagtgccg   2070720
tagctaacgc attaagcact ccgcctgggg agtacgaccg caaggttgaa actcaaagga   2070780
attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca acgcgaagaa   2070840
ccttaccagg tcttgacatc cctctgaccg ctctagagat agagctttcc ttcgggacag   2070900
aggtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg gttaagtccc   2070960
gcaacgagcg caacccctat tgttagttgc catcatttag ttgggcactc tagcgagact   2071020
gccggtaata aaccggagga aggtggggat gacgtcaaat catcatgccc cttatgacct   2071080
gggctacaca cgtgctacaa tggctggtac aacgagtcgc aagccggtga cggcaagcta   2071140
atctcttaaa gccagtctca gttcggattg taggctgcaa ctcgcctaca tgaagtcgga   2071200
atcgctagta atcgcggatc agcacgccgc ggtgaatacg ttcccgggcc ttgtacacac   2071260
cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc gtaaggagcc   2071320
agccgcctaa ggtgggatag atgattgggg tgaagtcgta acaaggtagc cgtatcggaa   2071380
ggtgcggctg gatcacctcc tttctaagga taaggaactg cgcattggtc ttgtttagtc   2071440
ttgagaggtc ttgtggggcc ttagctcagc tgggagagcg cctgctttgc acgcaggagg   2071500
tcagcggttc gatcccgcta ggctccattg gtgagagatc accaagtaat gcacattgaa   2071560
aattgaatat ctatatcaaa tagtaacaag aaaataaacc gaaaacgctg tagtattaat   2071620
aagagtttat gactgaaagg tcagaaaata aggttaagtt aataagggcg cacggtggat   2071680
gccttggcac taggagccga cgaaggacgt gacaaacgac gatatgcctt gggtagctgt   2071740
aagtaagcga tgatccaggg atttccgaat gggggaaccc aacaggtaat acctgttacc   2071800
cacatctgtt aaggatgtga ggaggaagac gcagtgaact gaaacatcta agtagctgca   2071860
ggaagagaaa gcaaaagcga ttgccttagt agcggcgagc gaaacggcag aagggcaaac   2071920
cgaagagttt actcttcggg gttgtaggac tgcaatgtgg actcaaagat tatagaagaa   2071980
tgatttggga agatcagcca aagagagtaa tagcctcgta tttaaaatag tctttgtact   2072040
tagcagtatc ctgagtacgg cgggacacgt gaaatcccgt cggaatctgg gaggaccatc   2072100
tcccaaccct aaatactccc tagtgaccga tagtgaacca gtaccgtgag ggaaaggtga   2072160
aaagcacccc gggaggggag tgaaatagaa cctgaaaccg tgtgcctaca acaagttcga   2072220
gcccgttaat gggtgagagc gtgccttttg tagaatgaac cggcgagtta cgttatgatg   2072280
cgaggttaag ttgaagagac ggagccgtag ggaaaccgag tctgaatagg gcgccttagt   2072340
atcatgacgt agacccgaaa ccatgtgacc tacccatgag caggttgaag gtgcggtaag   2072400
acgcactgga ggaccgaacc agggcacgtt gaaaagtgct tggatgactt gtgggtagcg   2072460
gagaaattcc aaacgaactt ggagatagct ggttctctcc gaaatagctt tagggctagc   2072520
gtcgacatta gagattcttg gaggtagagc actgtttggg tgaggggtcc atcccggatt   2072580
accaatctca gataaactcc gaatgccaat gaattatggt cggcagtcag actgcgagtg   2072640
ctaagatccg tagtcgaaag ggaaacagcc cagaccacca gctaaggtcc caaaataatt   2072700
gttaagtgga aaaggatgtg gggttgcaca gacaactagg atgttagctt agaagcagct   2072760
attcattcaa agagtgcgta atagctcact agtcgagtga ccctgcgccg aaaatgtacc   2072820
ggggctaaaa caatttaccg aagctgtgga tacctttata ggtatggtag gagagcgttc   2072880
tatgtgtgat gaaggtatac cgtgaggagt gctggaacgc atagaagtga gaatgccggt   2072940
atgagtagcg aaagacaggt gagaatcctg tccaccgtaa gactaaggtt tccaggggaa   2073000
ggctcgtccg ccctgggtta gtcgggacct aaggagagac cgaaaggtgt atccgatgga   2073060
caacaggttg atattcctgt actagagtat gtagtgatgg agggacgcag taggctaact   2073120
aaagcagacg attggaagag tctgtctaag cagtgaggtg tgaattgagt caaatgctta   2073180
attctataac attgagctgt gatggggagc gaagtttagt agcgaagtta gtgacgtcac   2073240
actgccaaga aaagcttcta gcgtttaaac atactctacc cgtaccgcaa accgacacag   2073300
gtagtcgagg cgagtagcct caggtgagcg agagaactct cgttaaggaa ctcggcaaaa   2073360
tgaccccgta acttcgggag aaggggtgct gacttaaagt cagccgcagt gaataggccc   2073420
aagcaactgt ttatcaaaaa cacagctctc tgctaaatcg taagatgatg tatagggggt   2073480
gacgcctgcc cggtgctgga aggttaagag gagtgcttag cgtaagcgaa ggtatgaatt   2073540
gaagccccag taaacggcgg ccgtaactat aacggtccta aggtagcgaa attccttgtc   2073600
gggtaagttc cgacccgcac gaaaggcgta atgatttggg cactgtctca acgagagact   2073660
cggtgaaatt ttagtacctg tgaagatgca ggttacccgc gacaggacgg aaagacccca   2073720
tggagcttta ctgcagtttg atattgagtg tctgtaccac atgtacagga taggtaggag   2073780
tctaagagat cgggacgcca gtttcgaagg agacgctgtt gggatactac ccttgtgtta   2073840
tggccactct aacccagata ggtgatccct atcggagaca gtgtctgacg ggcagtttga   2073900
ctggggcggt cgcctcctaa aaggtaacgg aggcgcccaa aggttccctc agaatggttg   2073960
gaaatcattc gcagagtgta aaggtataag ggagcttgac tgcgagagct acaactcgag   2074020
cagggacgaa agtcgggctt agtgatccgg tggttccgta tggaagggcc atcgctcaac   2074080
ggataaaagc taccctgggg ataacaggct tatctccccc aagagttcac atcgacgggg   2074140
aggtttggca cctcgatgtc ggctcgtcgc atcctggggc tgtagtcggt cccaagggtt   2074200
gggctgttcg cccattaaag cggcacgcga gctgggttca gaacgtcgtg agacagttcg   2074260
gtccctatcc gtcgcgggcg taggaaattt gagaggatct gctcctagta cgagaggacc   2074320
agagtggact taccgctggt gtaccagttg tcttgccaaa ggcatcgctg ggtagctatg   2074380
tagggaaggg ataaacgctg aaagcatcta agtgtgaaac ccacctcaag atgagatttc   2074440
ccatgattat atatcagtaa gagccctgag agatgatcag gtagataggt tagaagtgga   2074500
agtgtggcga cacatgtagc ggactaatac taatagctcg aggacttatc caaagtaact   2074560
gagaatatga aagcgaacgg ttttcttaaa ttgaatagat attcaatttt gagtaggtat   2074620
tactcagagt taagtgacga tagcctagga gatacacctg tacccatgcc gaacacagaa   2074680
gttaagccct agaacgccgg aagtagttgg gggttgcccc ctgtgagata gggaagtcgc   2074740
ttagctttaa tccgccatag ctcagttggt agtagcgcat gactgttaat catgatgtcg   2074800
taggttcgag tcctactggc ggagtaattg agttaagagg tttagacctc ttttttgtta   2074860
tgtaataata atctattttg tgttatagtg aaatgaacca aaaatagtac acaatgtggt   2074920
ataatcttct tatggcatat tcaatagatt ttcgtaaaaa agttctctct tattgtgagc   2074980
gaataggtag tataacagaa gcatcacacg ttttccaaat ctcacgtaat accatttatg   2075040
gctggttaaa gctaaaagag aaaacaggag agctaaacca ccaagtaaaa ggaacaaaac   2075100
caagaaaagt tgatagagat agacttaaaa actatcttac tgacaatcca gacgcttatt   2075160
tgactgaaat agcttctgaa tttggctgtc atccaactac catccactat acgctcaaag   2075220
ctatgggcta cactcgaaaa aagaaccaca cctactatga acaagaccca gaaaaagtag   2075280
ccttatttct taagaatttt aatagtttaa agcacctagc acctgtttag attgacgaaa   2075340
caggattcga tacttatttt tatcgagaat atggtcgctc attaaaaggt caattaataa   2075400
gaggcaaagt atctggaaga agatatcaga ggatttcttt ggttgcaggt ctaacaaatg   2075460
gtgaattaat cgctccaatg acttacgaag agacgatgac gagcgacttt tttgaagctt   2075520
ggtttcagaa ttttctctta ccaacattaa acacaccatc ggttattatt atggataatg   2075580
taagattcca tagaatgggg aagctagaac ttttatgcga agagtttggg cataaacttt   2075640
tacctcttcc tccctactcg cctgagtaca atcctattga gaaaacatgg gctcatatca   2075700
aaaagcacct caaaaaggta ttaccaagtt gcaatacctt ttacgaggct tttttatcct   2075760
gctcttgttt caattgacta tattagaggc gagacatttt tcggttcttt gtcaactgta   2075820
gtgggttgaa gaaagcgaag atctagaaag gacaaatttc gtcctttctt ttttgaagtt   2075880
ttcaaagttc ctaaaaccaa aggcattgtg cttgataagt ttgatgagat tattggtggc   2075940
ttccagtttg gcgttggaat aaggtaattg aagggcgttg acgattttct ctttatcttt   2076000
gaggaaggtt ttaaacaaag tctgaaacag aggtggaaaa gcaagagctg atagagatta   2076060
tagtggtgtt taaagtcttc ggaatagctc aaaagtttat ctagaatttc tttattagtc   2076120
aagtgcatac gaaaagtagg gcgataaaat cgtttatcac tcagtttctg actatcttgt   2076180
tgaatgagct tccagtagcg cttgatagcc ttgtattcat gggatttcgg atgatggctt   2076240
gtgttctgct ctcaagaaca gttatgatat tgagtttatc aaagtcctga gcaataaagc   2076300
tcatctccat ctcccgattg aaacagtcac tccccggact gtttcaacgt cctaggacat   2076360
aatctcagga agacgcgaaa aatcatgctc aaagtgaaaa tcattgttct tgcgaatgac   2076420
agttgaagtt gaaatagaca actgatgatc aatgtcggtc atagaagtct ttttaattag   2076480
cttctgagca atcttttggt tgatgataca aggaatttga tgattcttct tgacgataga   2076540
agtctcagcg agctccattt ttgagcaatg atagcactta aaacggcctt ttctaagaag   2076600
aattctagtt tgaatttttt tatactagaa aatcagaacc ataataccta tataaaaata   2076660
ttatagttct aataggattt acccaaaagt tttaaggcgg tctttttaga actttaattg   2076720
tttgaaattt aggtagcaaa tttgtttcta ttttgtcaac ttttcctatt tttatcttgt   2076780
tgaggctggt attttaacaa ttcaggaatt gatagtgaat gtgtaaaatt ttttgttaga   2076840
ataagtttat aaaaaagaaa aggagtattt gattatgtta caaaaaattt atgagcagat   2076900
ggctaatttc tatgatagta ttgaagaaga gtatggtcct acatttggtg ataattttga   2076960
ctgggaacat gttcatttta aatttttaat ttattattta gtgagatatg gcattggttg   2077020
tcgtaaggat tttattgttt accattatcg tgttgcttat cgtttgtatc ttgaaaaatt   2077080
ggtaatgaat cggggtttta tttcttgttg aggtaatttt agtaaatttc cgaactaatt   2077140
tactctttta tggaaagatg atagtaaata gctagtaatt tttctaaatc attttttaat   2077200
agttggaaat agcaaatctt tctattgttt cttcttgata aaaaggcgat tttttattat   2077260
aataaattgt aagatataat tgcaggtgag agtcctgcca tgtatgtgag aaaggaagag   2077320
cctgatggct cagacaagat tatgacttca gttgttgttg taggtaccca atggggtgat   2077380
gaaggtaaag ggaagattac agacttcctt tcagcgaatg cagaagtgat tgcacgttac   2077440
caaggtggtg ataatgctgg tcacacgatt gtgattgacg gtaagaaatt taagttgcac   2077500
ttgattccat ctgggatttt cttccctgaa aaaatatctg tcattgggaa tggtatggtt   2077560
gtaaatccta aatctcttgt aaaagagttg agctatcttc atgaggaagg tgtaacaact   2077620
gataacttgc gtatttctga tcgtgcgcat gttattttgc cttatcatat cgagttggat   2077680
cgcttgcaag aagaagctaa gggcgacaat aagattggta cgacaattaa gggaattggt   2077740
ccagcttata tggacaaggc tgctcgtgtt ggaattcgta ttgcagatct tttagataaa   2077800
gatattttcc gtgagcgttt agaacgtaac cttgctgaaa agaatcgtct ttttgaaaaa   2077860
ttgtatgaca gtaaagcgat tgttttcgat gatatttttg aagaatatta cgaatatggt   2077920
caacaaatca agaaatacgt gatagataca tctgttatct tgaatgatgc gcttgataat   2077980
ggcaaacgtg tgctttttga aggtgcacaa ggtgttatgc tagatatcga ccaaggtact   2078040
tatccatttg ttacgtcatc aaaccctgta gctggtggtg tgacaattgg ttctggtgtc   2078100
ggtccaagca agattgacaa ggttgtaggt gtatgtaaag cttatacgag tcgtgtagga   2078160
gatggtcctt tcccaactga gttgtttgat gaagtgggag aacgtatccg tgaagtgggt   2078220
catgaatatg gtacaacaac tggtcgtcca cgtcgtgtag gttggtttga ctcagttgtg   2078280
atgcgtcata gccgtcgtgt ttctggtatt actaaccttt ctttgaactc tattgatgtt   2078340
ttgagcggtt tggatactgt gaaaatctgt gtggcctatg atcttgacgg tcaacgtatt   2078400
gactactatc cagctagtct tgaacaattg aaacgttgca agcctatcta tgaagagttg   2078460
ccaggttggt cagaagatat taccggagtt cgcaatttgg aagatcttcc tgagaatgcg   2078520
cgtaactatg ttcgtcgtgt gagtgaattg gttggcgttc gtatttctac tttctcagta   2078580
ggtcctggtc gtgaacaaac aaatatttta gaaagtgttt ggtcctaaga gatttttaag   2078640
atttgtttaa gataggtcgg gtatactata gacggttaca agaagacctc ctaacttgtt   2078700
gtaacaaata tcctaaactt ttctttttca taataatctc cctatagagt caccgcattc   2078760
ggtggctttt tttgtgttgg gattcatgat ataataataa aatcgataag taggaaaaga   2078820
gaaaagagat gtattatacg cttgaagaaa aagaagtctt tatgagggag gctttgagag   2078880
aggctgagat tgctcttgaa cacgatgaaa ttccaattgg ttgtgtgatt gtcaaagatg   2078940
gggaaatcat tggtcgtggg cataatgcgc gtgaggaatt acagcgagcg gttatgcatg   2079000
cggaaattat ggctatagag gatgcgaact tgagtgagga gagctggcgc ttgctggatt   2079060
gcacactttt tgtgaccatt gaaccttgtg tcatgtgtag tggagcgatt gggcttgccc   2079120
gcattccaaa tgtggtctat ggggctaaaa accagaaatt tggcgctgct gggagtttgt   2079180
acaatatctt gacagatgag cgtctcaatc atcgtgtgga ggttgaaata ggaattttgg   2079240
aagatgaatg cgcagctatc atgcaggatt tttttagaaa tagacggaaa aaataatttt   2079300
gcttttaaaa tgaataggaa tgtgatataa taaatagtgg agcaacagtt ctgcgtgaag   2079360
cgggtcaggg gaggaatcca gcagccctaa gcgatttgaa ttgtgtgctc tttttttcgt   2079420
gctttttccg aataaataag atagaataat ctagaataaa tgataataga aaagagaaaa   2079480
ttatgaaaat tcgtggtttt gaattggttt cgagttttac agatgaaaat ttattgccca   2079540
agcgtgagac agcgcatgcg gctggttacg acttaaaggt tgctgtgcgt acagttgttg   2079600
cgccaggaga gattgtcttg gttccgacag gggttaaggc ttatatgcag ccgactgagg   2079660
ttctctacct ctatgatcgt tcttcaaatc ctcgtaagaa gggcttggtt ttaattaact   2079720
cagttggagt cattgatggg gattattatg gaaatcctgg aaatgaaggg catatttttg   2079780
cgcagatgaa gaatatcaca gaccaagagg ttgttcttga agttggggag cgtattgtcc   2079840
aggctgtttt tgctactttc ttaattgcag atggagatgc agctgatggc gttcgaactg   2079900
gtggatttgg atcgacaggg cactagaatg aagattatct ttgtacgtca tggggagcca   2079960
gattaccgtg agttagagga gcgttcttat ataggatttg ggatagattt ggcacccttg   2080020
tctgagatgg gacggcagca agtccagaaa ttgagcaaaa atcctttact ctcgtcagct   2080080
gaaataatcg tatcttctgc agtcacaaga gctttagaaa cggcttcgta tgtggtctgt   2080140
gctacgggtc ttcctttaag agtagagcct ttattacatg aatggcaggt ctataaaaca   2080200
ggaatagaaa actttgaaac agctagaaga ctgtttttag aaaacaaggg ggagttgctt   2080260
cctaatagtc ctattcaata tgagacagct acggaaatga agtctcggtt tctagaatgt   2080320
atgtctaagt atcgagaaca tcagactgtg gtagttgttg ctcatcgaat gctcatgcgc   2080380
cagtttgtgc caaatgagaa gattgatttt tgccaagtga ttgagtgtga gttagagata   2080440
tagaaagagg tttgtcatcg caaagaaaaa agcgacattt gtatgtcaaa attgtgggta   2080500
taattcccct aaatatctgg gacgttgccc caactgtggg tcttggtctt cttttgtgga   2080560
agaggttgag gttgccgaag ttaagaatgc gcgtgtgtcc ttgacaggtg agaaaaccaa   2080620
gcccatgaaa ctagctgagg tgacttccat caatgtcaat cgaaccaaga cggagatgga   2080680
ggaattcaac cgtgtgcttg gaggcggagt ggtaccagga agtctcgtcc ttatcggtgg   2080740
ggatcctggg attgggaaat caactcttct cctacaagtc tcaacccagt tgtcccaagt   2080800
ggggacagtt ctctatgtca gtggggagga gtctgcccag cagattaaac tacgtgcaga   2080860
gcgcttaggt gatattgata gtgagtttta tctctatgca gagaccaata tgcagagtgt   2080920
tcgtgcagaa gtggagcgta tccagccaga ctttctcatt attgattcca tccagaccat   2080980
catgtctcct gagatttcag gggtgcaggg gtctgtttct caggtgcgtg aagtgaccgc   2081040
tgaactcatg cagttggcca agaccaataa cattgccatc tttatcgtag gtcatgtgac   2081100
caaagaagga accttggctg ggcctcgtat gttggagcat atggtggata cggtgcttta   2081160
ctttgaaggg gagcgtcacc acacctttcg tattttgaga gcggtcaaaa atcgttttgg   2081220
ttccactaat gagattggga tttttgagat gcagtcgggc ggcttggttg aggtactcaa   2081280
tccgagtcaa gttttcctag aagagcgttt ggatggggcg actggttcct ccatcgttgt   2081340
aaccatggaa gggacgcgtc cgattttggc ggaggttcag gctttggtaa caccgaccat   2081400
gtttggaaat gccaagcgta ctacgacagg acttgatttt aaccgtgcta gcttgattat   2081460
ggctgttttg gaaaaacggg cagggcttct cttgcaaaat caggatgcct atctcaaatc   2081520
tgctggtggt gttaaattgg atgaacctgc gattgacttg gctgttgcag ttgctattgc   2081580
ttcgagctac aaagacaagc caactaatcc tcaggaatgt tttgtcggag aactgggctt   2081640
gacaggagag attcggcgcg tgaatcgtat tgagcaacgc atcaacgaag ctgctaaact   2081700
gggctttact aagatttatg tacctaagaa ttccttgaca ggaatcactc tgcctaagga   2081760
aattcaggtc attggcgtga caacgattca ggaagtcttg aaaaaggtct ttgcataatc   2081820
cgtgacaaat tctcttaaaa atgataagat aggagaaata tttgactatc aaattttcaa   2081880
ggagggaatc gtgtcgtatt ttgaacagtt tatgcaagcc aatcaggctt atgttgccct   2081940
acatgggcag ttaaatctgc cacttaaacc taaaaccaga gtagccattg tgacctgtat   2082000
ggactcacgt ttgcacgttg cgcaagctct aggtttggca cttggggatg ctcatatttt   2082060
gcggaatgca ggtggtcgag tgactgagga tatgattcgt tctctagtta tttcccagca   2082120
acaaatgggg acaagagaaa ttgtggtatt gcatcataca gactgtggtg ctcagacctt   2082180
tgaaaatgaa ccttttcagg agtatttgaa ggaagaattg ggtgtcgatg tgtcagacca   2082240
ggacttcttg cccttccaag atatagaaga gagtgtacgc gaggatatgc aactgcttat   2082300
cgagtctccc ctaataccag acgatgtcat tatctctggt gccatttaca atgttgatac   2082360
aggaagtatg acagtcgtag aattataaat acttcattta gaaagaaagt gtatgaagaa   2082420
aagcaatatt ttatttattt ttattttatt gctatgtatt ggtttacagt atgaaaccat   2082480
ctactatacg gacggttcga ggtcaggtgc ggaatatgga ctaatgggag tttctatctt   2082540
tctagctctc ttttacatga ttccggctct ttattttctc ttccgtattg ggaaaaatgg   2082600
gaattgccaa agaaggtttt gattctgtct ttattgggag ggatgttcct ttcaggctgg   2082660
ttgtctagtt ttgctaatac ttatatccat gatttactgg gggttctttt cccagatagt   2082720
ccatttttaa atgcctttga aagtgctatt gcggctcctt tggtagaaga acccttgaaa   2082780
ttattgtcac ttgtttttgt tttggctttg attcctgtgc gaaaattaaa atctttgttt   2082840
ttacttggaa ttgcttccgg tttgggattc caaatgatta aggatattgg ttatattcgt   2082900
acggatttgc cagagggctt tgactttact atttcgcgaa ttttagagcg tatcatctca   2082960
ggaattgcct ctcactggac tttttcaggt ctagctgtag taggtgttta cttgctttac   2083020
agagcctata aaggacagaa ggttggcaag aaacagggcc ttatttttct aggtttagcc   2083080
ttgggaactc acttcttgtt taactctcct tttgtggagt tggaaacaga gttgccttta   2083140
gcgattccag tggttacggc tattgctctc tatggttttt atcatgctta ttgctttgtt   2083200
gagaaacaca atgagttgat gacctagaat atttttcaaa agaatgatgc aagggtacaa   2083260
atatggtgcc cttcttttat ttttgattga aaaatagtgc aaaaagcgct acaatggtag   2083320
atggaaaatc ttgtgaaaag cacaagttat acatatatac cggaggaaat catgtctttt   2083380
tctgatttaa agctgtttgc cctttcttct aataaagaat tggcagaacg tgtggcgcag   2083440
gagattggga tagagttggg gaaatcaagt gttcgccaat tttcagatgg agagattcag   2083500
gtcaacattg aagaatcaat ccgtgggaaa cacgtcttta tcttacaatc aactagttcg   2083560
cctgtaaatg acaatctgct tgaaattttg attatggtag atgctttgaa gcgtgcgagt   2083620
gcagaatctg tcaatgttgt catgccttac tatgggtatg cacgtcagga tagaaaggcg   2083680
agagcgcgtg agccaatcac ttcaaaactt gtcgcaaata tgcttgaagt agctggagtg   2083740
gatcgtttat tgaccatcga cttgcatgct gcgcaaattc aaggattctt tgatattcct   2083800
gtggatcatt tgatgggtgc tcctctgatt gcagattatt ttgagcgtcg tggtatggtt   2083860
ggttctgact atgtggttgt cagcccggac catggagggg tgactcgtgc tcgtaagttg   2083920
gcagaatttt tgaaaacatc tatcgctatt attgataaac gtcgtagcgt tgataagatg   2083980
aatactagtg aagttatgaa tatcatcggt aaggttgaag gcaagacttg tatcttgatt   2084040
gatgatatga ttgataccgc tggaacgatt tgtcatgcgg cagatgctct tgcggaagct   2084100
ggtgctgttg aagtctatgc aagctgtacg cacccagttc tttctggtcc tgctacggac   2084160
aatatccaaa aatcagctat taagaaattg gttgttttgg ataccatcta tctgccagaa   2084220
gagcgtttga ttgataagat tgagcagatt tcaatcgctc atctcctagg ggatgctatc   2084280
gtacgtattc atgaaaaacg accactttct ccacttttcg atattgagaa aaaaatttaa   2084340
tgaccaagcc tgagatgatt ctcaggtttt ttcgtctttt ttccgaataa atagatagta   2084400
gcggtgaatc tagtaaagct agatttaaaa ctgtgatata ataaaaagag aagaaatatg   2084460
actgtacgtc atcagaagtt tcagcgacca tcatttttga acagtgatag cacttgaatc   2084520
gacgctttct aaggagaatt cttgtaggca taccagtcgt ttcaagataa ggaattttag   2084580
aaggtttttg aaagtcatat ttcttcaatt ggtttccgca ctcagggcaa gatggggcgt   2084640
cgtagtccag tttggcgatg atttccttgt gtgtatcctt attgatgatg tttaaaatct   2084700
ggacattagg gtctttaatg tctagtaatt ttgtgataaa atgtaattgt tccatatgat   2084760
tctttctaat gagttgtttt gtcgcttttc attataggtc atatgggact ttttttctac   2084820
acaaaatagg ctccataata tccatagggg atttacccac tatggatatt atggagccat   2084880
tttacaacag tgcctcaaat tcagatactg acatacctaa ttgctggctg gcaacctcag   2084940
aagtcagaag accttggcgt actatgtcta ggaaggcaaa aagtttcctt tctgcccttc   2085000
cttcaacttt cccacgctct agtccttgtt caaggccttc agccctagca gtttccaagg   2085060
catagtcctg tgctaacaag acttgttctt ctcgcatatg tagttgacta aacattttcc   2085120
tgtcctcctc ggaccagctc ttgtagtcca gcagttgatt tgcttgggta atggctcgtt   2085180
gcggttgctg ggtaaagggc ttgttgccga aaaactccaa ccatggcttg cgaaccttgt   2085240
ctttgctggt ttctctgtat tttttaattc caagaatgcc atcttaacca gatggttttc   2085300
ctgtccattg ttggtaatcg ccaatacctc acctgttgtg tcttcgcgca tactaaagct   2085360
atgaaaagcc aggtcatctg agaaataatt actatccacg atagcaatgg cgtaaacagg   2085420
agcgatgtgt ttgtagctct agtgagtatc accttctcgc tgacgaattt tttcaagatt   2085480
ttgattaacc tgactgcaca ggtaagccca caagtgattg atgaaaaaat tctgatgatg   2085540
gacttgaatc tcaataatta cttgagtacc gttatccaac tccgccaaga cgtctatact   2085600
ggtataaaaa tcctgcaccg agtaaggcat ggagagtaat acgtgaatat cgcttccctc   2085660
caaaatggtc acattttttg ctggcaagtc cagcatatcg cgaataaatt gacaagtgat   2085720
ttctggattg ctgaatattt tcttagcaat caaatcatta gttgggctga tgcccggatg   2085780
tctgagaatc ctcctattcc tccttctata gtgagttgaa ataagatgtg aataactcta   2085840
tcaggaaagt caaattaatt tatagaaata ttttagcagt caaggtgtac tattatagat   2085900
tcaatatact atattatagc acatttttaa atctaggttt actaaattct ctggctctat   2085960
ctatttattc ggaaaaagtt tgaaaaatac ttgctctagc tcttcccaat ggtatttttt   2086020
gattctttcc tttataatgg gtgtatggat aagaaaaaat tattattgat tgatgggtct   2086080
tctgtagctt ttcgggcgtt ttttgcgctg tatcagcagt tggaccgttt taagaatgtg   2086140
gctggtttgc ataccaatgc gatttatggt tttcagttga tgttgagtca tttattggag   2086200
cgggttgagc cgagtcatat tttggtggct tttgatgcgg gaaagacgac cttccggaca   2086260
gagatgtatg cggactataa gggtggtcgg gccaagactc ctgatgagtt tcgtgagcaa   2086320
tttcctttca ttcgtgagtt gctggatcat atggggattc gtcactatga tctggctcag   2086380
tatgaggcgg atgacatcat tgggacgctg gataagctag cagagcagga tggttttgat   2086440
attactattg tcagtgggga caaggatttg attcagctga cggatgagca tacggtggtt   2086500
gaaatttcca agaaaggtgt ggctgagttt gaggccttta cgccagatta cctcatggaa   2086560
gaaatgggcc tcacaccagc tcagtttatc gatctcaagg cgctcatggg tgataagtcg   2086620
gataatatcc ctggggtgac caaagtcggt gaaaagacgg gtattaagct cttgctggag   2086680
catggttcgc ttgaggggat ttatgaaaat attgatggaa tgaagacttc taagatgaag   2086740
gaaaatctca tcaatgacaa ggaacaggcc tttttgtcta aaacactagc gaccattgat   2086800
accaaggcac cgattgcgat tggtttagag gacttggtct atagtggtcc agatgttgaa   2086860
aatcttggga aattctacga tgagatgggc ttcaaacagc taaagcaggc tttaaatgtg   2086920
tcgtcagctg atgtgtctga gagtttggat tttactattg ttgaccaaat cagtcaagat   2086980
atgctgagtg aagagtctat cttccacttt gagctttttg gtgagaatta ccatacggat   2087040
aatttggttg gatttgtctg gtcttgtggg gataagctct atgccacaga caagcttgag   2087100
ctgttgcaag acccgatttt caaggatttc ttagaaaaaa catctctgag agtttatgac   2087160
tttaagaagg ttaaagttct tttgcaacgt tttggtgtgg atttgcaggc gcctgctttt   2087220
gacatccgtt tggctaaata cctcctttcg actgtggagg acaatgaaat tgcgaccatc   2087280
gctagtcttt atggtcagac ttacttggtt gatgatgaaa ctttctacgg taagggtgtt   2087340
aaaaaggcca ttcctgaacg tgagaaattc ttggaacact tagcttgtaa acttgctgtt   2087400
ttggtagaaa cagagcctat tttacttgaa aaactcagcg aaaatgggca attagagctt   2087460
ctttatgata tggagcaacc tctggctttt gtccttgcca agatggaaat tgctgggatt   2087520
atggtcaaga aagagacctt gcttgagatg caggctgaaa atgagcttgt cattgaaaaa   2087580
ctgactcaag agatttacga gctggctggt gaggagttta atgtcaactc gcctaagcag   2087640
ttgggcgtgc ttctctttga gaaattggga cttcctctag aatacactaa gaaaaccaag   2087700
acaggttatt cgacagcagt ggatgtttta gagcgtctcg ctcctattgc tccgattgtt   2087760
aagaaaatcc tggattaccg tcaaattgct aagattcaat ctacttatgt aattggcttg   2087820
caggactgga ttttggctga tggaaagatt catactcgct atgtgcagga tttgacccag   2087880
accgggcgtt tgtctagtgt ggatccaaac ttgcaaaata ttcctgcccg attggaacag   2087940
gggcgcttga ttcggaaggc ttttgtgcca gagtgggagg atagtgtgct actcagctct   2088000
gactattcac agattgaatt gcgcgttttg gcgcatattt ctaaggatga gcacttgatt   2088060
aaggccttcc aagagggggc agatatccat acttcgacag ccatgcgggt ctttggcatt   2088120
gagcgtcctg atgatgtgac tgcaaacgac cgtcgcaatg ccaaggcagt taactttgga   2088180
gtggtttatg ggatttcaga ctttggcttg tctaataatt tgggaattag tcgtaaggaa   2088240
gccaaagcct acattgatac ctactttgaa cgttttccag gtattaaaaa ctacatggat   2088300
gaagtggtgc gggaggcgcg tgataagggc tatgtagaga ccctctttaa gcgtcgccgt   2088360
gagttgccag atatcaattc gcgcaacttc aatattcgtg gttttgcgga gcgaactgct   2088420
atcaactcac ctatccaggg ttcggcagca gatattctca agattgccat gattcagctg   2088480
gataaagcct tggttgcagg tggttatcag actaagatgc tgttacaagt gcacgatgaa   2088540
atcgtccttg aagtgcctaa atctgaattg gtagagatga aaaaattggt gaaacaaacc   2088600
atggaagaag ccattcaact cagtgttcct cttatcgcag atgagaatga aggggcaacc   2088660
tggtacgagg ctaaataaaa agggggctag tcctcctttt ttgtagtata attctgcaaa   2088720
ccttttcaaa atgtgctata ctgatgaaaa aggaggattt ctatgagtca agaatttatc   2088780
aatccaagtg atggcgtgat tcgtcagtat ctcgcaacga gtaaaaccct tgctgtggtg   2088840
ggtttgtctg accgtgaaga aacaaccagc aatcgagtaa caaaggaaat gcaggctcgg   2088900
ggctataaaa tcatcccagt caattcccaa ggcggcaggt ggcgaaatct tgggtgaaaa   2088960
ggcttatgct agcctcgctg aaattccttt tcctgtagat attgtcaatg tttatcgtcg   2089020
cagtgaattt ctgcccgatg tggcgcgtga ttttctcaaa gctgatgcca agattttttg   2089080
ggcacagcta ggacttgaaa gtttagaagc gaaagagatt ttgcgtgatg gtggatgtga   2089140
tgatatcgtg atgaatcgct gtatcaagag agaacatact cgcttgattg aggaagcata   2089200
agaaaaaggt agctgatggg ctaccttttg tgttatactc aatgaaaatc aaagagcaaa   2089260
ctaggaaact agccacgggc tgctcaaaac actgttttga ggttgcagat agaactgacg   2089320
aagtcagctc aaaacactgt tttgaggttg tagatacgac tgacgaagtc agctcaaaac   2089380
accgttttga ggttgcagat agaactgacg aagtcagctc aaacaccgtt ttgaggttgc   2089440
agatagaact gacgaagtca gtaacatata cctacggcaa ggcgacgttg acgtggtttg   2089500
aagagatttt cgaagagtat tagaaaatgc cgataagggt ctgcatacca agagtggtga   2089560
ggatgatggc aatccagcag atggctccaa gaagaatgga ttttccactg gatttgacca   2089620
tagcgaccag attggttttg agaccgatag cactcatggc catgacaata aggaatttag   2089680
agagttcttt gagaggagta aagaaactac tggacacacc tagagaggtg agtagtgtag   2089740
tgaggagaga ggcaaggata aagtaaagga taaaaagtgg gaagactttt ttcagttgca   2089800
ggctttgctt gttttcttgt tggcgacttt gccagtagga tagaaagagc gtgataggga   2089860
taatggccaa agtacgtgtg agtttaacaa tggttgcaga ctcgagggta ttgctttggt   2089920
aaagactgtc ccaagcgctg gcggcagccg ttacagagga agtgtcgttg accgcagtcc   2089980
ctgcaaagag ggcgaagcct tcattggata gatgaagcca ggtgccgagg gttggaaaga   2090040
tgagcgcagc caagacattg aagaaaaaga taacggaaat ggcttgggct acttcctttt   2090100
ccttagcatc aataacgggc gctgtcgctg caatggcaga acccccacag atagaagaac   2090160
ctactccaac caaggtagcc agttttgtat ccagggcaaa gaaacgctgg aagaggtagg   2090220
caataatcag agctattgag atagtggaca ggatgacagg gagtgaagat tggccaactg   2090280
cgaagacctg cgagatattg agaccaaaac caagcaagac aacggcatat tggagcaact   2090340
tcttggaact aaaggtcaaa ccagcatcca gttgtttata ggacgagaga aagggatgta   2090400
ggagcatgcc tatgaaaatg gcaaaaacgg gcgcgccaac cacagggaag aatcctccta   2090460
agtaccaaga taggatggaa atgagaaggc aggccaagat acctgctcca ttttttgata   2090520
gaaatgacat aaaaacctcc aaataaaatc tattaccatt atagacctat aaacaggaaa   2090580
agtaaaatag aaagtggaaa gctattctct aatgtatttt tgcggtcggg gggcttttgt   2090640
agtataatag agatacgttt tgaaagtagg aggtatctat ggacttaact aagcgcttta   2090700
ataaacagtt agataaaatt caagtttcgt tgattcgtca gtttgaccag gctatttcgg   2090760
agattcctgg ggtcttgcgt ttgaccttgg gggaacctga ttttacaacg ccagaccatg   2090820
tcaaggaggc gggcaagcga gcgattgatc agaaccaatc ctactataca gggatgagtg   2090880
gtctgctgac tctacgtcag gcagccagtg actttgttaa ggaaaagtac caactggact   2090940
atgctcctga aaatgaaatc ttggttacaa ttggggcgac agaggcttta tctgcgactt   2091000
tgacggctat tttggaagag ggagacaagg tacttttgcc agctcctgct tatccaggct   2091060
atgaaccgat tgttaactta gttggggcag aaattgttga gattgatacg actgaaaatg   2091120
gttttgtctt gactcctgag atgttggaga aggccatttt ggagcagggt gataagctca   2091180
aggcggttat tctcaactat ccagccaatc cgacaggaat tacctacagt cgagagcagt   2091240
tagaggcctt ggcagctgtt ttacgcaagt acgaaatttt tgttgtctgt gatgaggttt   2091300
actcagaatt gacctacaca ggcgaagcca tgtgtctcta ggaacgatgt tgagagacca   2091360
ggctattatt atcaatggtt tgtctaaatc gcatgccatg acaggttggc gtttggggct   2091420
gattttcgct cctgcgacct tcacagccca gttaatcaag agtcaccagt acttggtcac   2091480
tgccgcaaat accatggcgc aacatgctgc ggtagaagcc ttgacggctg gtaaaaacga   2091540
tgcggagccc atgaagaagg aatatatcca acgtcgggac tatatcatcg aaaaaatgac   2091600
tgctcttggt tttgagatta tcaaaccaga cggtgccttc tatatttttg ctaaaattcc   2091660
agcgggctac aatcaagact cctttgcttt tctgaaggat tttgctcaga agaaggccgt   2091720
tgcctttatc cctggtgcag cctttggacg ttacggggaa ggctacgtcc gcctatctta   2091780
tgcagccagc atggagacta tcaaagaagc catgaaacga cttgaggagt acatgagaga   2091840
agcatgattc agtctatcac gagtcaaggc ttggtgcttt acaatcgcaa ttttcgtgag   2091900
gatgacaagc tcgtcaaaat ttttacagag caggttggca aacgcatgtt ttttgtcaaa   2091960
cacgctggtc agtctaagct ggcgcctgtt attcagccct tggtgctggc acgatttctc   2092020
ttgcgaatca atgatgacgg actcagttac atcgaagact atcatgaggt catgactttt   2092080
cccaagatta atagtgacct ctttgtcatg gcctatgcga cctatgtggc agctcttgca   2092140
gatgctagtt tgcaggacaa tcagcaggat gctcccttgt ttgctttttt gcaaaagact   2092200
ttggagttga tggaagcagg cttggattat caggttttga ccaatatttt tgaaattcaa   2092260
attttgactc gatttggaat cagcctcaat tttaatgagt gtgtcttctg ccatcgggtt   2092320
ggtcaggctt ttgacttttc tttcaaatat ggagcctgcc tctgtccaga gcattatcat   2092380
gaggataaga gacgttgtca tctcaatccc aatatcccct atctgctcaa tcaatttcaa   2092440
gctattgatt ttgagacttt ggagaccatt tcgctcaagc ctggaatcaa gcaagagcta   2092500
cgccaattta tggatcaatt atatgaagag tacgttggga ttcacctaaa atcaaagaaa   2092560
tttattgatt ccctagcaga ctggggacaa ttactaaaag aggaaaagaa atgaaaaaaa   2092620
tcgcagtaga tgccatgggg ggcgattacg cacctcaggc cattgttgag ggtgtcaatc   2092680
aagccctatc tgacttttca gatatcgagg ttcaacttta cggagatgaa gctaaaatca   2092740
agcaatatct gacagcgaca gagcgcgtca gcattatcca tacggatgag aagattgatt   2092800
cggatgatga acctacgaga gctattcgga ataagaaaaa tgccagtatg gtattggcag   2092860
ccaaggctgt caaagatggt gaagcagacg ctgtcctttc ggctgggaat acaggtgcct   2092920
tgttggcagc aggattcttc atcgtgggtc gtatcaagaa tatcgaccgt cctggactca   2092980
tgtctacctt gcctaccgtt gatggaaaag gttttgacat gctagacctt ggtgccaatg   2093040
cagaaaatac agcccagcac ctccatcaat atgcggttct aggttccttc tatgctaaaa   2093100
atgtccgtgg cattgcgcaa ccacgcgttg gtttgctcaa caacggaaca gagagtagca   2093160
agggcgaccc gcttcgtaag gaaacttatg aattactggc ggctgatgaa agtttgaact   2093220
ttatcggaaa cgtggaagcg cgtgatttga tgaatggcgt tgcagatgtt gttgtggcag   2093280
atggtttcac gggaaacgct gtgctcaaat ccatcgaagg gacagctatg ggaatcatgg   2093340
gcttgctcaa gacagctatt acaggtggtg gtcttcgagc gaaactaggt gccctccttc   2093400
tcaaggacag cctcagtggt ttgaaaaaac agctcaatta ttcagatgtt ggtggagcgg   2093460
tcttgtttgg tgttaaggca cctgttgtca agactcatgg ctcaagcgat gccaaggctg   2093520
tttatagtac gattcgtcag atccgtacca tgctagaaac agacgtggtt gcccagactg   2093580
cgcgtgaatt ttcaggagaa taaaagagat gacagaaaaa gaaatttttg accgtattgt   2093640
gaccattatc caagagcgac agggagagga ctttgtcgtg acagaatcct tgagtctgaa   2093700
agacgatttg gatgcggatt ctgttgactt gatggagttt atcttgactc tggaagatga   2093760
atttagtatc gaaatcagcg atgaagaaat tgaccaactc caaaacgtag gagatgtggt   2093820
taaaatcatt caaggaaaat agcaatcgga gttccaagtc aacggaagta gatggttttt   2093880
agaaatgaga aatatcggac aagctggtaa aatcttggct gacagtggtt atcaagggct   2093940
catgaagata tatcctcaag cacaaactcc acgtaaatcc agcaaactca agccgctaac   2094000
agttgaagat aaagcctgta atcatgcgct atctaaggag ataagcaagg ttgagaatat   2094060
ctttgccaaa gtaaaaacgt ttaaaatgtt ttcaacaacc tatcgaaatc atcgtaaacg   2094120
cttcggatta cgaatgaatt tgattgctgg tattatcaat catgaactag gattctagtt   2094180
ttgcaggaag tctaatagta aaaaagtgat tagaaaacat cttttttaaa aatagagatg   2094240
attttgaaac aaaaaagcta attcaagacg tttcgatgcc aattcaagat ttggatgaaa   2094300
aaaattaata gatactgtta tactaaactt gtcaagtttg taacaagaca aatattaaaa   2094360
ataaaaaaga ggtattcgtt atgaatacaa aaacgatgtc acaatttgaa attatggata   2094420
ctgagatgct tgcttgcgtt gaaggtggcg gatgcaattg gggagatttt gccaaagcag   2094480
gtgttggagg aggagcagca cgaggtcttc agctaggaat taaaacaaga acatggcaag   2094540
gtgcagcaac tggtgctgtg ggaggagcta tacttggagg tgtggcctat gcagcgacat   2094600
gttggtggta attatggatt ttaaaagttt tattattggt ttagtagttg gtatatttgg   2094660
tccttatatg gatgatttaa ttagaaaaaa atttttaaag tcttcggaga agaaaacaga   2094720
aaaatctgtt aaaaaataat caaaactata aatgatgaat ctgaatcaaa attattttgc   2094780
gcatgtaaag aggagtctta tagtaacgag tcaaaaaagg agtaactatg aatcgtaatt   2094840
tagaacggtg ttatctattc tgactaggaa tagatcatac cagaggtagc ttagaaatag   2094900
cagagacatt agaaattgaa gtaataaata ggatgtcgta agtgttacta tcaatgattt   2094960
atttgtttca agcttgccta gggtgacagt aaaaaatcaa tttcctttca atagcatatt   2095020
tttagtgggc aggactcttg ttctgcctat ttttttatcc aaaaagtgca gttgggaggg   2095080
agataggctc atttgggaag gaagtccagt ttttgtttag tgattggggt aagatagttg   2095140
ttatcagatg agttaatact cttcgaaaat caaattcaaa ccacgtcaac gtcgccttgc   2095200
cgtatatatg tgactgactt cgtcagtcct atctacaacc tcaaaacagt gttttgagca   2095260
gcctacggct agtttcctag tttgctcttt gattttcatt gagtattagg gaaaaggaga   2095320
tgaatatgaa atttgggaaa cgtcattatc gtccgcaggt ggatcagatg gactgcggtg   2095380
tagcttcatt agccatggtt tttggctact atggtagtta ttattttttg gctcacttgc   2095440
gagaattggc taagacgacc atggatggga cgacggcttt gggcttggtc aaggtggcag   2095500
aggagattgg ttttgagacg cgagccatta aggcagatat gacgcttttt gacttgccgg   2095560
atttaacttt tccttttgtt gcccatgtgc ttaaggaagg gaaattgctc cactactatg   2095620
tggtgactgg gcaggataag gatagcattc atattgccga tccagatccc ggggtgaagt   2095680
tgactaaact gccacgtgag cgttttgagg aagaatggac aggagtgact ctttttatgg   2095740
cacctagtcc agactataag cctcataagg aacaaaaaaa tggtctgctc tcttttatcc   2095800
ctatattagt gaagcagcgt ggcttgattg ccaatatcgt tttggcaaca ctcttggtaa   2095860
ccgtgattaa cattgtgggt tcttattatc tgcagtctat cattgatacc tatgtgccag   2095920
atcagatgcg ttcgacacta gggattattt ctattgggct agtcatcgtc tacatcttcc   2095980
agcaaatctt gtcttacgct caggagtatc tcttgcttgt tttggggcaa cgcttgtcga   2096040
ttgacgtgat tttgtcctat atcaagcatg tttttcacct ccctatgtcc ttctttgcga   2096100
cacgcaggac aggggagatc gtgtctcgtt ttacagatgc taacagtatc atcgatgcgc   2096160
tggcttcgac catcctttcg attttcctag atgtgtcaac ggttgtcatt atttcccttg   2096220
ttctattttc acaaaatacc aatctctttt tcatgacttt attggcgctt cctatctaca   2096280
cagtgattat ctttgccttt atgaagccgt ttgaaaagat gaatcgggat accatggaag   2096340
ccaatgcggt tctgtcttct tctatcattg aggacatcaa cggtattgag actatcaagt   2096400
ccttgaccag tgaaagtcag cgttaccaaa aaattgacaa ggaatttgtg gattatctga   2096460
agaaatcctt tacctatagt cgagcagaga gtcagcaaaa ggctctgaaa aaggttgccc   2096520
atctcttgct taatgtcggc attctctgga tgggggctgt tctggtcatg gatggcaaga   2096580
tgagtttggg gcagttgatt acctataata ccttgctggt ttactttact aatcctttgg   2096640
aaaatatcat caatctgcaa accaagcttc agacagcgca ggttgccaat aaccgtctaa   2096700
atgaagtgta tctagtagct tctgagtttg aggagaagaa aacagttgag gatttgagct   2096760
tgatgaaggg agatatgacc ttcaagcagg ttcattacaa gtatggctat ggtcgagatg   2096820
tcttatcgga tatcaattta accgttcccc aagggtctaa ggtggctttt gtggggattt   2096880
cagggtcagg taagacgact ttggccaaga tgatggttaa tttttacgac ccaagtcaag   2096940
gggagattag tctgggtagt gtcaatctca atcagattga taaaaaagcc ctgcgccagt   2097000
acatcaacta tctgtctcaa cagccctatg tctttaacgg aacgattttg gagaatcttc   2097060
ttttgggagc caaggagggg acgacacagg aagatatctt acgggcggtc gaattggcag   2097120
agattcgaga ggatatcgag cgcatgccac tgaattacca gacagaattg acttcggatg   2097180
gggcagggat ttcaggtggt caacgtcaga gaatcgcttt ggcgcgtgct ctcttgacag   2097240
atgcgccggt cttgattttg gatgaggcga ctagcagttt ggatattttg acagagaagc   2097300
ggattgtcga taatctcatt gctttggaca agaccttgat tttcattgct caccgcttga   2097360
ctattgctga gcggacagag aaggtagttg tcttggatca gggcaagatt gtcgaagaag   2097420
gaaagcatgc tgatttgctt gcacagggtg gcttttacgc ccatttggtc aatagctaga   2097480
aagaggagag gatgaaacca gaatttttag aaagtgcgga gttttataat cgtcgttacc   2097540
ataatttttc cagtagtgtg attgtaccca tggcccttct gcttgtgttt ttacttggct   2097600
ttgcaactgt tgcagagaag gagatgagtt tgtccactag agctactgtc gaacctagtc   2097660
gtatccttgc aaatatccag tcaactagca acaatcgtat tcttgtcaat catttggaag   2097720
aaaataagct ggttaagaag ggggatcttt tggttcaata ccaagaaggg gcagagggtg   2097780
tccaagcgga gtcctatgcc agtcagttgg acatgctaaa ggatcaaaaa aagcaattgg   2097840
agtatctgca aaagagcctg caagaagggg agaaccactt tccagaggag gataagtttg   2097900
gctaccaagc cacctttcgc gactacatca gtcaagcagg cagtcttagg gctagtacat   2097960
cgcaacaaaa tgagaccatc gcgtcccaga atgcagcagc tagccaaacc caagccgaaa   2098020
tcggcaacct catcagtcaa acagaggcta aaattcgcga ttaccagaca gctaagtcag   2098080
ctattgaaac aggtgcttcc ttggccggtc agaatctagc ctactctctt taccagtcct   2098140
acaagtctca gggcgaggaa aatccccaaa ctaaggttca ggcagttgca caggttgaag   2098200
cacagatttc tcagttagaa tctagtcttg ctacttaccg tgtccagtat gcaggttcag   2098260
gtacccagca agcctatgcg tcagggttaa gcagtcaatt ggaatccctt aaatcccaac   2098320
acttggcaaa ggttggtcag gaattgaccc ttctagccca gaaaattttg gaggcagagt   2098380
caggtaagaa ggtacaggga aatcttttag acaaggggaa agttacggcg agtgaggatg   2098440
gggtgcttca tcttaatcct gagaccagtg attctagcat ggttgcagaa ggtgccctac   2098500
tagcccaact ttatccatct ttggaaagag aagggaaagc caaactcaca gcttatctaa   2098560
gttcaaaata tgtagcaaga atcaaggtcg gtgattctgt tcgctatact acgactcatg   2098620
atgccgggaa tcaacttttc ctagattcta ctattacaag tattgatgcg acagctacta   2098680
agactgagaa agggaatttc tttaaaatcg aggcggagac taatctaact tcggagcagg   2098740
ctgaaaaact taggtacggg gtggaaggcc gcttgcagat gattacgggc aagaaaagtt   2098800
acctacgtta ttatttggat caatttttga acaaagagta atgttcgtgt ttttagagtt   2098860
aaataatttt taaactgtga gaaagattct tcttgcagtt ttttctttac aatttttgaa   2098920
aaacatctac tatttattcg gttaaattct tgtgtttttt ggttttttgt ggtaaaatgt   2098980
gctcaagtaa tacgaaaggc gaactttaaa atgtcaaaac aattgatcta ttcgggaaaa   2099040
gctaaagata tctatacaac tgaggatgaa aatcttatta tttcaactta caaggaccag   2099100
gcgactgctt tcaacggtgt caagaaggag cagattgcag gtaagggagt cttgaataat   2099160
cagatctcat cttttatttt tgagaaatta aatgtggctg gtgtggcgac tcactttgtg   2099220
gagaaacttt cagacacgga acaactcaat aaaaaggtta agattattcc tttggaagtc   2099280
gtgctccgca actatactgc tggttccttt tcaaaacgtt ttggtgtgga tgagggaatc   2099340
gccttggaga ctccgattgt cgaattttac tacaaaaatg atgatttgga tgatccattt   2099400
atcaatgatg agcatgtgaa attcctacag attgcgggtg accagcagat tgcctacttg   2099460
aaggaagaaa cgcgtcgtat caatgaacta ttgaaagtct ggtttgctga gattgggctt   2099520
aaattgattg actttaagct agagttcggt tttgacaagg atggcaagat tatcttggca   2099580
gacgaatttt caccagataa ctgccgcttg tgggacgctg atggcaacca catggataag   2099640
gatgttttcc gtagaggatt gggagaacta accgacgttt atgagattgt ttgggaaaag   2099700
ttgcaggaat tgaaataatc tgtttgcaac ggaaaacctt cgtctctcaa ctaaaaggac   2099760
tcaggctgaa aaggtccccc agaccttttc actctgtaga gaactaggtg aactaacaga   2099820
tgtttacgaa attgtctggg aaaagttgca gggtttaaaa taacaacctc aaggctgttt   2099880
gggaatattg caagagctga aataaaggaa taagaattga tggataaacg tatttttgtt   2099940
gaaaaaaagg ctgattttca ggtcaagtca gagagtttgg ttagagagct ccagcacaac   2100000
ttgggactgt caagcttgaa aagtattcgt attgtgcaag tatatgatgt atttgacttg   2100060
gctgaggact tgtttgcacc tgcagagaag cacattttct ctgagcaggt aaccgaccat   2100120
gttttagatg aagtatctgt gcaggcggat cttgctaact atgctttctt tgccattgaa   2100180
agtctgccag ggcagtttga ccagcgtgca gcttcgtcac aggaagcctt gcttttgttg   2100240
ggaagttcga gtgacgtgac agtcaacaca gcccaacttt acttggtgaa taaagatatt   2100300
gatgcgactg agttggaagc tgtcaaaaac tacctgctca atccagttga ttctcgtttc   2100360
aaggatatca cgacagggat tgccaagcag gagttttcag agtcagacaa gaccattccc   2100420
aaattgactt tctttgaaag ctatgcagca gaagactttg ctcgctacaa ggccgaacaa   2100480
gggatggcca tggaagtgga tgatttgctc tttatccaag actactttaa gtcaatcggg   2100540
cgcgtgccaa ctgagactga actcaaggtt ttggacactt actggtctga ccactgccgt   2100600
catacgactt ttgagacaga gttgaaacac atcgactttt cagcttctaa atttcaaaag   2100660
caattgcagt caacctatga caagtatatt gccatgcgcg aggaattagg tcggtctgaa   2100720
aaaccacaaa ccttgatgga tatggcgact attttcggtc gttatgagcg tgctaatgga   2100780
cgattggatg atatggaagt ctctgacgaa atcaatgcct gctcagttga aattgaagtg   2100840
gacgttgatg gtgtcaagga accttggctc ctcatgttta aaaacgaaac ccacaaccat   2100900
ccaacagaaa ttgagccatt tggtggagcg gctacctgta ttggtggagc tattcgtgat   2100960
ccgttgtcag gccgttccta tgtttaccaa gccatgcgta tttcaggtgc tggtgatatt   2101020
acagcaccga tttcggaaac tcgcgctggg aaattgccac aacaagtcat ttctaaaaca   2101080
gcagctcatg gttattcttc atatggtaac cagattgggc ttgcaacaac ctacgttcgt   2101140
gaatacttcc acccaggctt tgtagctaaa cgtatggaac ttggtgccgt tgttggtgcg   2101200
actcccaagg gcaatgttgt ccgtgaaaaa cctgaagcag gtgatgtgat catccttctc   2101260
ggaggcaaaa caggtcgtga tggtgtcggt ggtgcgacgg gctcttctaa ggttcaaaca   2101320
gttgagtctg tagagactgc tggtgctgag gttcaaaaag gaaatgccat cgaagaacgc   2101380
aagattcagc gcctcttccg taatggcaat gtcactcgtc tgatcaagaa gtccaatgac   2101440
tttggggcag gcggtgtctg tgtggctatc ggtgaattgg cagacggtct tgaaatcgac   2101500
ctcaacaagg tgcctcttaa ataccagggc ttgaatggta cagaaattgc catctctgaa   2101560
tcacaagaac ggatggcggt cgtggttcgt cctgaagatg tggatgcctt cgttgccgaa   2101620
tgtaacaaag aaaatattga tgctgttgtg gtggcgacag taactgaaaa accaaatctt   2101680
gtcatgcact ggaatggtga gacaatcgtt gacttggagc gtcgtttcct tgacaccaat   2101740
ggtgtgcgcg tggttgtcga tgccaaagtt gtggacaagg atgtcaaact cccagaagag   2101800
cgtcaaacat ctgctgaaac actggaatca gataccctta cggttctatc tgacctcaac   2101860
catgcaagtc aaaaaggatt acagactatc tttgactgct ctgttggacg ctcaacggtt   2101920
aatcacccac ttggtggtcg ttaccaactc acaccaactg aggcatctgt gcagaaattg   2101980
ccagttcaac acggtgtgac tcatactgcg tcggtcattg ctcaaggttt caacccatat   2102040
gtagctgaat ggtctccata ccacggtgct gcttatgcgg ttatcgaagc aactgctcgt   2102100
ttggtggctg ctggtgccaa ctggttcaag gctcgtttct cttaccaaga gtatttcgag   2102160
cgtatggata aacaagcaga gcgtttcggt cagccagtag ctgctcttct aggttctatt   2102220
gaagcacaaa ttcagcttgg cttgccatct atcggtggta aggactccat gtctggtacc   2102280
tttgaagaat tgaccgttcc gccaaccttg gctgcctttg gggtgacgac ggcagatagc   2102340
cgtaaggtgc tctctccaga atttaaagct gttggggaaa atatctacta catcccaggt   2102400
caagccctct ctgcagagat tgattttgac ttgattaaga aaaattttgc tcagtttgaa   2102460
gccatccaag ctgaccataa agtgacatct gcatcagctg tcaaatacgg tggtgtagtt   2102520
gaaagtttgg ctcttgctac ctttggaaac tatattggtg cagaggtgac cttgcctgaa   2102580
cttgaaacag ctttgacagc tcaattaggc ggctttgtct tcacatctcc tgaagaaatt   2102640
gctggagtag agaaggttgg acaaacgaaa gcagacttta cactgactgt caacggtgtg   2102700
aagctagatg gacacaagct tgacagtgca tttcaaggga cattggaaga agtttaccca   2102760
acagaattta cccaagcgaa agaactagaa gaagtaccag ctgtggcatc agatgttgtg   2102820
attaaagcca aagaaaaggt tgaaaaacct gtggtttaca tcccagtctt tccaggaacc   2102880
aactcagaat atgattcagc taaggccttc gaaaaagaag gtgcagaggt caatttggtg   2102940
ccattcgtga ccttgaatga agaagctatt gtcaagtcag ttgaaactat ggttgacaat   2103000
atcgacaaga ctaatattct cttctttgct ggtggattct cggctgcgga tgaaccagat   2103060
ggttcagcta agtttatcgt caatatcctg cttaatgaaa aagtgcgtgt ggctattgat   2103120
agctttatcg cccgtggtgg tttgattatc ggtatttgta atggattcca agccttagtc   2103180
aaatcgggtc tcctacccta cggaaacttt gaagctgcta acagtactag cccaaccctc   2103240
ttctacaatg atgccaacca acacgtggcc aagatggtgg aaactcgcat tgccaatacc   2103300
aactcaccat ggttggttgg tgtgcaagtg ggcgatatcc acgctattcc tgtttcgcac   2103360
ggtgaaggga agtttgtcgt gacggctgag gaatttgcag agctccgtga caatggacaa   2103420
attttcagcc aatacgttga ctttaacggt aaaccaagta tggattctaa gtacaatccg   2103480
aatggttctg tccatgccat cgaaggaatt accagcaaga atggtcaaat catcggtaag   2103540
atgggccact cagaacgtta tgaggatggt cttttccaaa atatcccagg caataaagac   2103600
caacacctgt tcgcatcagc ggttaaacat ttcactggaa aataagactt acagattttc   2103660
taatagatag tatcagtaat gtaaaagtca tgtaaatcta gctcttgatg attacaaatg   2103720
aaaattaggt ataaaaaatg acatacgaag taaaatctct taatgaagaa tgtggtgttt   2103780
tcggtatttg gggacatcca gatgctgcta agttgaccta ttttggactc cacagtcttc   2103840
aacaccgtgg tcaggagggg gcaggaatcc tctccaatga tcaaggacaa ctgaagcgcc   2103900
atcgtgacat ggggctttta tcagaagttt tcagaaatcc agctaatttg gataaattga   2103960
caggagctgg tgcgattggg catgtgcgtt atgcgactgc tggcgaagct tctgtagata   2104020
acatccagcc cttcctcttc cgttttcacg atatgcagtt tggtttggct cataatggaa   2104080
atctgaccaa tgcagcctct ctcaagaaag aactggaaca aagaggagca attttcagcg   2104140
cgacttcgga ctctgaaatc ttggctcacc tcattcgtcg cagtcataat cctagcctga   2104200
tgggcaaaat caaggaagcg ctcagccttg tcaaaggtgg ttttgcctat atcttgctgt   2104260
ttgaggacaa gttgattgcg gctcttgacc caaatggatt ccgaccgctt tcgattggta   2104320
aaatggctaa tggagcagtt gttgtatctt ctgaaacctg tgcttttgag gtcattggtg   2104380
ccgagtggat tcgtgatttg aagccaggtg agattgtgat cattgatgac gagggcattc   2104440
agtatgacag ctatacagat gatacccagt tggcggtttg ttctatggag tatatctact   2104500
ttgctcgccc tgattctaat atccacggtg tcaatgtcca tacggcacgt aagagaatgg   2104560
gagcgcaatt ggcgcgagaa tttaagcatg aggcagatat tgtagttggt gtgcccaatt   2104620
cttccctaag cgcggctatg ggatttgcgg aagaatcagg cttaccaaat gaaatgggtc   2104680
tgatcaaaaa ccaatacacc cagcgaactt ttatccaacc gactcaagaa ttgcgggagc   2104740
aaggagtgcg gatgaaactg tctgctgttt cgggtgttgt caaaggcaaa cgtgtggtca   2104800
tggtggatga ttccattgta cgtggaacaa cctctcgtcg tatcgttcag ctcttgaaag   2104860
aagcgggtgc gactgaggtt cacgttgcca ttggaagtcc tgcactagcg tatccatgtt   2104920
tctacgggat tgatatccag acccgtcagg agctgattgc agccaatcat acggtcgaag   2104980
aaactcgcca aatcattggt gcggacagtc tgacttatct ttcaattgat ggcttgattg   2105040
agtcgattgg tatcgaaaca gatgcgccga acggtggtct ctgtgtcgct tactttgacg   2105100
gtgactaccc aacgcctctt tatgactacg aagaagacta tcgtagaagt ttggaagaaa   2105160
agaccagttt ttacaagtag gcgacagatt ctccattaaa gaaaaggaaa aaataaatga   2105220
caaataaaaa tgcatatgcc tcacgtctca ctactgacta aaggcttaag catttagtca   2105280
gtagacgctt tgtcctatag gatcaaagct agagccctga ctagtatttt tagataaaaa   2105340
gatggtttat ctaaaaatac gtcgcagtct ttctcaaaaa aagaaaagga aaaataaaat   2105400
ggcaaataaa aatgcgtacg ctcaatctgg tgtggatgtt gaagcgggtt atgaagttgt   2105460
tgaacggatt aaaaagcacg tggcccgtac ggagcgtgca ggtgtcatgg gagctcttgg   2105520
tggctttggt ggtatgtttg acctttccaa gactggggtt aaagaacccg tcttgatttc   2105580
agggactgac ggtgtcggaa ccaagctcat gttggctatc aagtacgaca agcacgatac   2105640
catcgggcag gactgtgtgg ccatgtgtgt caacgacatc attgctgcag gtgcggaacc   2105700
cctctatttt ctcgactacg tagcgacagg gaagaatgaa ccagctaagc tagaacaagt   2105760
ggttgctggt gtggcagaag gttgtgtgca ggctggtgct gccctcatcg gtggggaaac   2105820
ggctgaaatg ccgggcatgt acggcgaaga cgactatgac ttggctggtt ttgcggtcgg   2105880
tgtggctgaa aaatctcaaa tcattgacgg ttcaaaggtg gtagagggag atgttcttct   2105940
cggacttgct tcaagtggga ttcactcaaa tggttactct ttggttcgtc gtgtctttgc   2106000
ggattacaca ggtgaggaag tcctaccaga attggaaggc aagaaactta aggaagttct   2106060
acttgagccg actcgtatct atgtcaaggc tgtcttgccg ctcatcaaag aagagttggt   2106120
caacggcatt gcccacatca caggtggtgg ctttatcgaa aatgtccctc gtatgtttgc   2106180
agatgaccta gctgctgaaa ttgatgaaag taaagttcca gtgcttccaa ttttcaaaac   2106240
ccttgaaaaa tacggtcaga ttaaacacga agaaatgttt gaaatcttca atatgggtgt   2106300
gggacttatg ttggcggtca gccctgaaaa tgtagagcgt gtaaaagaat tgttggatga   2106360
agcagtctat gaaattggtc gcatcgtcaa gaaagaaaac gaaagtgtca ttatcaaatg   2106420
aaaaaaatag cggtttttgc ctctggtaat ggctcaaatt ttcaggtgat tgccgaagaa   2106480
tttccagtgg agtttgtctt ttcagaccat cgtgatgcct atgtgcttga gcgtgcaaag   2106540
cagctcggcg ttctgtccta tgcttttgaa ctcaaggagt ttgagagcaa ggcagactac   2106600
gaagcagccc ttgtcgaact cttggaagaa caccagattg acttggtttg cctagcaggc   2106660
tacatgaaaa tcgttggacc aaccttattg tcggcttatg aaggtcggat tgtcaacatt   2106720
catccagcct acttgccaga atttccagga gctcatggga ttgaggatgc ttggaatgct   2106780
ggcgtgggtc agtctggtgt gaccattcac tgggtggatt cgggtgtgga tacaggccag   2106840
gtcatcaaac aggttcgtgt gccacgacta gctgatgata ccattgacag atttgaagct   2106900
cgcatccatg aagcagagta caggctgtat ccggaagtag tgaaggctct atttacagat   2106960
tgactttttg atgattcata tgatatcttt gattttaaat tggagtcagt gtttgttgaa   2107020
gacggcttca aacggaggta tttgtaatgt tagaatctaa aaaaacaact cgatatgtat   2107080
tttatgtcta tctgatgtta ttaacttggg gaatcttatt taagtttgaa acaaatcctg   2107140
aatttatagc atttttctta gctccaaggt atatcaattg gattccattt tcagaaccac   2107200
taatagtcga tggaaaaatt gtttttgctg aaatgttatt taatctgatt ttctttattc   2107260
cattaggtgt ttgtttccct ttgataaaaa ctaatttatc tagtttaaga atagtcggga   2107320
caggtttctt gattagttta ttgtttgagt gcttacagta tattttagca ataggtataa   2107380
cagatataac ggatttgact ttaaatacgc taggtgtctg tgtaggctta ctgatttatc   2107440
aaatttttat aagagtgttc aaatcacaga ctagaaaatg gatcaatatc ttaggtatgc   2107500
ttagccttgg ttttgcttat cttgttttac tgttactgca tttacttagt gtttaactaa   2107560
tgattaaaaa ggagaatata atgactaaac gcgtcttaat cagcgtctca gacaaagcgg   2107620
gcattgttga atttgcccaa gaactcaaaa aacttggttg ggagattatc tcaacaggtg   2107680
gaactaaggt tgcccttgat aatgctgggg tggataccat tgctatcgat gatgtgactg   2107740
gtttcccaga aatgatggac ggtcgtgtga agaccctcca cccaaatatc cacggagggc   2107800
ttctcgctcg tcgtgacttg gatagccact tggaagcggc taaggacaac aagattgagc   2107860
tcattgacct tgtggtggtc aacctttacc catttaagga aactatcctt aaaccagatg   2107920
tgacttatgc tgatgcagtt gaaaatatcg atattggtgg gccatctatg cttcgttcag   2107980
cagcgaaaaa tcatgccagt gttacagttg tggtagatcc tgctgactac gctgtggttt   2108040
tggatgaatt ggcagcaaac ggcgaaacct cttatgaaac tcgccaacgt ttagcagcca   2108100
aagtatttcg tcacacagcg gcttatgacg ccttgattgc agaatacttc acagctcaag   2108160
tgggtgaaag caagcctgaa aaactcactt tgacttatga cctcaagcaa ccaatgcgtt   2108220
acggtgagaa tcctcaacaa gacgcggact tttaccagaa agctttgcct acagactact   2108280
ccattgcttc agccaaacag ctcaacggga aagaattgtc atttaataat atccgtgatg   2108340
cagatgctgc tatccgtatc atccgtgact tcaaagatag tccaaccgtt gtggctctca   2108400
aacacatgaa tccatgtgga attggtcaag ctgatgacat cgagactgct tgggactacg   2108460
cttatgagtc tgacccagtg tctatctttg gtgggattgt cgtcctcaac cgtgaggtgg   2108520
atgctgcgac agctgagaag atgcacggcg ttttcctcga aatcatcatt gcaccaagct   2108580
atacggatga agcgctagcc attttgatca ataaaaagaa aaacttgcgt atccttgcct   2108640
tgccatttaa tgctcaagag gctagcgaag tggaagcaga atacacaggt gtagtcggtg   2108700
gacttctcgt gcaaaatcaa gacgtggtca aggaaagccc agctgactgg caagtggtga   2108760
ctaaacgtca gccaactgag acagaagcga ctgctcttga gttcgcttgg aaggctatca   2108820
agtacgtcaa atcaaatggt attatcgtga ccaacgacca catgacactt ggtgttggtc   2108880
caggtcaaac caaccgtgtg gcttctgttc gccttgccat tgaccaagcc aaagatcgtc   2108940
tggacggggc ggtccttgct tcagatgcct tcttcccatt tgcggataac gtggaagaaa   2109000
tcgccaaagc aggaattaag gccatcatcc agcccggtgg ctctgtccgt gaccaagaat   2109060
ccatcgaagc agcggataaa tacggcttga ctatggtctt tacaggtgtg agacatttta   2109120
gacattaaga agataaaagg gaagaaaaca gtttctttcc ttttttggct taaaatacta   2109180
actgaaacaa gattaaaacg aacttttttg atataatgtt ggtaaataat tcgcaaaaga   2109240
ggttgaggaa tgaaactgct tgttgtcggt tctggtggtc gtgagcatgc gattgctaaa   2109300
aagttacttg aatcaaaaga cgtggaaaaa gtctttgtag ctcctgggaa tgatgggatg   2109360
actctggatg gtttggaatt ggtaaatatc tctatttccg aacattataa attgattgac   2109420
ttcgcaaaga ccaatgatgt tgcttggacc tttatcggtc cagatgatgc ccttgctgct   2109480
ggtatcgtgg atgattttaa ccaagctgga cttaaggcct ttggtccgac tagggctgca   2109540
gcggagctgg agtggtccaa ggatttcgcc aaggaaatca tggtcaaata cggcgttccg   2109600
acagcaacat atggcacatt ttcagatttc gaggaagcca aagcctatat cgaaaagcat   2109660
ggtgcgccta tcgtagtcaa ggcggatggc ttggcacttg ggaagggtgt cgtcgttgct   2109720
gagacggttg agcaagcggt cgaagccgct catgagatgc ttttggacaa taaatttggt   2109780
gactcaggtg cgcgcgtggt tattgaggaa ttccttgaag gagaggaatt ttcactcttt   2109840
gcctttgtca atggtgataa gttctacatc atgccaacgg ctcaggacca caaacgtgcc   2109900
tatgatggcg acaaagggcc taacacgggt ggtatgggtg cctatgcgcc agtcccacac   2109960
ttaccacaga gtgtagttga tacagcggtt gacaccattg tcaagccagt tctagaaggg   2110020
gtgattaaag aaggtcgccc ttatctggga gttctttacg cagggcttat cctgacagct   2110080
gatggaccga aagtcattga gttcaacgct cggttcggag atccagaaac tcagattatc   2110140
ttgcctcgct tgacctctga ctttgctcaa aatatcacag atatcctgga tagcaaggag   2110200
ccaaatatca tgtggacgga caagggtgtg actctgggtg tggttgtcgc atccaagggc   2110260
tacccgctag actatgaaag gggcgttgag ttgccagcca agacagaagg cgatgtcatc   2110320
acctactatg caggggctaa gtttgcggaa aatagcagag cactgctctc aaacggcgga   2110380
cgagtttata tgctcgttac cacagcagat accgtcaaag aagcccaagc cagcatatac   2110440
caagaactat accaacaaaa aatagaagga ctcttctacc gaacagatat cggaagcaag   2110500
gcaattaagt aaagatataa gaataacgcg ccgtagtcgc caaacacgat aatggtcgtc   2110560
gtggtgaaaa gaccagaaca gtgaatgttc tggtcagggg gaaacttgga gaccttaggc   2110620
tcaaagttta ggaatgaaac cgaaggtttg cttccgcctc catcacctaa gaccattatc   2110680
aaaaagaaaa ataaaaattc acaaaatacg ttaatgatcg tatggtttgc gagcgttagc   2110740
gagctaatat agaacaatca ccgccgttgt gaaagaacga ttggatgata atccaatcgt   2110800
tcagggaaat tggaagacct tgggtttcca atttaggcat gagacacctt tggtggctgc   2110860
tgccgtccct cacaagctaa ggtgattgtt gaaaaagagg aaaaaggaga agaaatgaaa   2110920
ccagtaattt ccatcatcat gggctcaaaa tccgactggg caaccatgca aaaaacagca   2110980
gaagtcctag accgcttcgg tgtagcctac gaaaagaaag ttgtttccgc acaccgtaca   2111040
ccagacctca tgttcaaaca tgcagaagaa gcccgtagtc gtggcatcaa gatcatcatc   2111100
gcaggtgctg gtggcgcagc gcatttgcca ggcatggtag ctgccaaaac aacccttcca   2111160
gtcattggtg tgccagtcaa gtctcgtgct cttagtggag tggattcact ctattctatc   2111220
gttcagatgc cgggtggggt gcctgttgcg accatggcta tcggtgaagc tggagcgact   2111280
aacgcagctc tctttgccct ccgtctcctc tctgtagaag ataagtccat tgcggatgca   2111340
cttgccaact ttgctgaaga acaaggaaaa atcgcagagg agtcgtcaaa tgagctcatc   2111400
taaaacaatc ggaattatcg gtggcggtca actgggtcag atgatggcca tttctgctat   2111460
ctacatgggc cacaaggtta tcgcgctgga tcctgcggcg gattgcccgg tctctcgtgt   2111520
ggcggaaatc attgtggcac cttataacga tgtagacgcc ctccgtcagt tggcagaccg   2111580
ttgcgatgtc ctcacttatg agtttgaaaa tgtcgacgct gacggtttgg atgccgttat   2111640
caaggatgga caactccctc aaggaacaga tctgctccgc atttcgcaaa atcgtatttt   2111700
tgaaaaggac tttttgtcaa acaaggctca agtcactgtg gcaccctaca aggtcgtgac   2111760
ttctagccta gacttggcag atatcgactt gtcgaaaaac tatgtcctca agactgcgac   2111820
tggtggctac gatggtcatg gacaaaaggt tattcgttca gaagcagact tggaagcagc   2111880
ctatgcgcta gcagactcag cagactgcgt cttggaagaa tttgtcaact ttgaccttga   2111940
gatttctgtc atcgtgtcag gaaatggcaa ggaggtgacg tttttcccag ttcaggaaaa   2112000
tatccaccgc aacaatatcc tgtctaagac catcgtacca gcccgcattt ctgaaagtct   2112060
agtagacaag gctaaagcta tggcagtgcg aatcgcagaa caactcaact tgtctggaac   2112120
tctctgtgtg gaaatgtttg cgacagctga tgacatcatt gtcaatgaaa tcgccccacg   2112180
accacataac tctgggcact attctattga agcctgtgat ttctctcagt ttgacaccca   2112240
tattctgggt gttctcggag caccattacc agtcatcaaa ctccatgcgc cagccgttat   2112300
gcttaatgtc ctcggtcagc atgtcgaggc tgctgaaaaa tatgtcacag aaaatccaag   2112360
cgcccacctc cacatgtatg gtaaaataga agcaaagcat aatcgtaaga tgggacatgt   2112420
gactttgttt agtgatgtgc cggatagtgt ggaagagttt ggggaaggga ttgattttta   2112480
ggacaagtct atgatacaaa ttatcgttaa tacatttatt gaaaagtata agactggagc   2112540
agttgttgaa gtgttgtatg ccagtgctga ccaagataag gtacaagcta aatatgaaga   2112600
actagctgca caataccccg aaaattattt agctatctat aatgtaccgc tggatacgga   2112660
tttgaataca ctagatcatt acccgtctgt gtttattgga aaagaggagt ttgagtagaa   2112720
atcttggttt acctagatag cttattccca acagcttaag aagaaaggaa aaattaacac   2112780
atgatcaacc gttactctcg ccctgagatg gcgaatattt ggagtgaaga aaataaatac   2112840
cgtgcttggc ttgaggtgga aatcctctct gacgaggcat gggctgagtt gggggaaatc   2112900
cctaaggaag atgtggcttt gattcgcaag aaggcggact ttgacatcga ccgtattttg   2112960
gaaattgagc aggagacgcg ccacgatgtg gtggctttca cgcgtgcggt ttctgagact   2113020
cttggtgaag agcgcaagtg ggttcactat gggttaactt ctactgacgt ggtggatact   2113080
gcttatggtt acctctacaa gcaggccaac gacatcatcc gtcgtgacct tgaaaacttc   2113140
actaatatca tcgctgacaa ggccaaggag cacaagttca ccatcatgat ggggcgtact   2113200
catggtgtgc acgctgagcc gacaaccttt ggtcttaaat tagcaacttg gtacagcgaa   2113260
atgaaacgca atatcgagcg cttcgagcat gcggctgctg gtgtagaagc tggtaagatt   2113320
tctggtgcgg ttgggaactt tgccaatatc ccaccatttg tagaggagta tgtctgcgat   2113380
aaacttggca tccgtgccca agaaatctct acacaagtcc ttcctcgtga ccttcacgct   2113440
gagtactttg cggttcttgc cagcattgcg acttcaatcg aacgtatggc gactgagatt   2113500
cgtggtctac aaaaatctga gcaacgcgaa gtagaagagt tctttgctaa agggcaaaaa   2113560
gggtcttcag caatgcctca caaacgcaac ccaatcggtt ctgaaaatat gactggtctg   2113620
gcgcgtgtca ttcgtggtca catgattacg gcttatgaaa acgtcgctct ctggcatgaa   2113680
cgcgatattt ctcactcatc agctgagcgt atcatcacac cagatacgac cattttgatt   2113740
gactacatgc tcaaccgttt tggaaatatc gtcaagaact tgacagtctt cccagaaaat   2113800
atgatccgaa acatgaactc gacttttggt cttatcttta gccaacgggc tatgttgaca   2113860
ttgattgaaa aaggcatgac ccgtgagcaa gcctatgact tggtgcaacc aaaaacagcc   2113920
tactcttggg acaaccaagt agactttaaa ccacttcttg aggcagattc agaagtaaca   2113980
tcacgtctca cacaagaaga aatcgatgaa atcttcaacc cagtttatta caccaaacga   2114040
gtggatgata tctttgaacg tcttggacta ggtgattaat taaaaaataa acagcgagct   2114100
tcaatctcgc tgtttatttt ttatcgaaaa gacttagtct tcttttcttt tagtgagtcc   2114160
ataggctgct agtgtggaca tgagtcctgc gactactagt cctgcagaat cgtgagttcc   2114220
tgtttcagga agttttttct ctgttaccac aggagctgga tcttgaggaa gaactttgct   2114280
ttcctcagca ggagcagttg atggagctgg ttggcttggg atttctagtt ttggtttttc   2114340
ttcagcaata gcggcttgtc cgttttcatc gcctacatgt gttaccatag ttccgacttc   2114400
gactatttga gtaacggctt cctgtgctac gacactattt acaagtgttt tcacttcctt   2114460
accatcggca gaagtgctca cagagtagaa gttgctacga tgtccattga cgcccttagt   2114520
aatgacttgt gtttttcctt tgagtaagag tggattttca caagtcactg tggtaaatgg   2114580
aatttcttct tcttggatat ccagtctagg ttttacctca gtagttggtg caagaccact   2114640
ttcatcaccc ttgtgagtta caggagcgcc aacttcaacc acttggttta taacttcttt   2114700
ggttacctgg ctatcaagga ctgtttctgt tgtttttcca ttttcagtga gtacagagat   2114760
gtaatgagtt cgttcacctt tgactcctgc tgtgataata ttttcctgac cggctgggag   2114820
gttaggattt tctttcttga taacttcaaa tggaatttct tcagttcttg tgatgagttc   2114880
tggtctggtt tcaacattgg cagccacttc attttcatct aggcttcctg aatgagttac   2114940
agctggtttg aggccttgaa gagcggcttt taggttggct acaagcgtgt caagctcagc   2115000
ttgtttatta cggttgaggt tgtaatttag agctgtttta gctgcgtcaa gggcctcaag   2115060
actttcttta ctatatcctt ctaagtttgt aggaatttta gctaattctt cgcggagagc   2115120
attataatta gcacgaaagt agtctttgtt gtggtctgca aaggcagtca tgagttcaaa   2115180
gatttcctct tccttgtatt cagcgcttgg tctatctgcc cagattgaaa gcatacttcc   2115240
gactgttgga agatctactt caggatattt ggtagaagct agttgattga atggtgtttt   2115300
tccagtattc tcaatagctt tcttgaggaa accaccacca tcttctggtt tttgaccaag   2115360
aatgtagtac cagtcaccgt tggtattcaa gaatttatag cctttgcttg ctaggtattg   2115420
aggtgatgcg aggttatatc cccaccagcc tttagaccag taagaaatca agacatcttt   2115480
gtcaaactga acatcgtcct tgtcttcata gtagaagcca tcgttgaagg ccattggttg   2115540
aagccctctt tctttggcca tagctgcgag ggtgttggca tattcggcaa atttgccata   2115600
gagttgatac cacttgaggt agtaccagcc ttgggcacta gtcgcatcgt tggcgtattc   2115660
gtcagtacca aagttgaaaa tctttgtttt acctgcaaag aagtccatgt atttaccgat   2115720
gagggctttt acaaagttca tcgcttcttc gtttttcaag tccatagttg tttttgaaac   2115780
tttatcaaag tgggcttgag gatttttaat acctaatttt tccatggcaa ccagcatagc   2115840
atccatgtga cctggactgt taatagctgg gatgagaccg atgtccttag atttagcgta   2115900
ttcaattagc tctgttactt ctgcctgtgt tagtgcagta ccgtttggat cgtcgtagta   2115960
agctttagtt ccttcgataa tagctttttt aacgtcatca ctagcatagg tttttccgtt   2116020
ggcagtaatg gtcatatcat cgagtagaaa gcgaagtccg tcatttccta gaaggagatg   2116080
gacatcagaa tatccgagct cactggcctt gtctacgatg cgtttgagct ggttcagagt   2116140
aaagtatttg cgtccagcat cgattgagat taccttgttt ttggcaagtt tttcaacctc   2116200
acgtttagct tcttcttctt tttgagcttc aggcgtgagg gtcaagttgt tgacagtttc   2116260
ttgaagttta gcaatggctt gatcaatcgt atcttgttgg gcacggctaa ggttgctatc   2116320
gagagagcga atagcttttt cagcttcttt tacggccgtg acgctttctg cagtataacg   2116380
gttcaggtct tttggtacct cgttaagtgc ttgctctgca gattcataat cagctgcgaa   2116440
gtattcagcg ttggcatttg caaaatgacg catgagtttg aagaggcgtg atggtgaata   2116500
acgtgcagat ggagtgtcag cccaagcagc taccatacca ccgatgattg ggatatcagc   2116560
tccttctgtt tttggtacag aagtgattgg tgtgttttta ataccattga gcccctgatc   2116620
gagattgtac cagccttggc catcagcgtt tcgtccaaga acgtagtacc aagcatcatt   2116680
ggtattaagg atttggtgac ctttttcagc tagtagttta gaagaagcga catcgtagcc   2116740
tccccaacca ccagtccaca tagaaacgat gatgtctttg tcaaaactac caaagcttgt   2116800
gtcgctattg tagtagatac cgtcgttaaa agccattggt ttgagaccgt gcgattttac   2116860
aatacgagcg aggtcattgg cgtaggcaat aaatttttca tagcctttta cagggtagcc   2116920
ttcgtttgga tagtatttat cagcttgaag cacactccaa cctttagcat ctgtcgcatc   2116980
attggcatat tcatcaagtc cgatgttgaa gatttcagtc tttttcgcga aataagcagc   2117040
atacttgtcg ataagggctt ttgtaaaagc gacagcttgt tcgttgtcaa gatcgacagt   2117100
acgggctgat ttcttcccaa aatagctaaa gttagggttt tggattccca attctttcat   2117160
ggcattgaga atcgcatcca tgtgtccagg actatttact gtcggaatga gaccgatacc   2117220
tttatctttg gcatagttaa tcagatctgt catttgactt tctgttaagt gattgccgtt   2117280
tggatcgttg taataatcat ttgtaccttt ttcaatggcg cgtttgacat cgtcactggc   2117340
ataggtcttg ccgttagctg tgatgctcat atcgtccaac atgaaacgga gtccatcatt   2117400
tccgactaat aggtgtaaat cagtgtagcc ataatgtttc gctttatcga tgatttcctt   2117460
gagctgttct ggtgagaaat atttacgtcc agcatcaata gaaacaattt tctttttcgc   2117520
tagtttttca tttacagttg cagcacgttc ctttcctgcc tctgttgccg gtttgtcagc   2117580
ctctgctttc gcttcatctt ttttagctgg tttatccttg tcagtcttgt ctgtatttga   2117640
ctctttagaa tcaacctctt tcgcttcttc ctttttaggg ctagcttctt ctgccttttt   2117700
attagcagtt tctttttcag cagaagttgg agttaccact tctgctttat cactaggagt   2117760
tgaactaact tcctcttgtg gtttttcttc tgtttttgga agactagcta ccttatcagt   2117820
agctggagtt tctgtttcta cagtttttgg agcttctggt tgaagcactg ctttaggtgt   2117880
ttcctcagtc cgattttcgg atgattgagg ggaatcagaa accgtatgga tggtcggttg   2117940
gttttctgta gtagtaggag taactccatc ggctgcaaca gtctgtgctt ggaaggcaaa   2118000
tccaattaga acagaagctg ctcctacagc gtatttacga atagaaaaac gctgttgttt   2118060
ttcatgtttc attgcaaaac ctcctgattg cattgttata ttgatagcga ttatataaat   2118120
caacgccttt attttatttc ttatattaat ttcttatatt aacgagagtc aagaggagat   2118180
gacaaaaaac tataataagt ataaaaaaat ataaaattta aacttaagat ttcagattgg   2118240
tcggaaaaaa tacgtatata tatctagtat aatttttggt tctatttcta taaaatattc   2118300
cacaaattat agaattttcc aaaaataggt aagcgctacc tttttggtgt agtataataa   2118360
gcatagaaaa agcccaagcg attagctcag gttttcttct tagtgatcac ggtcacatga   2118420
gataaattta atcttgtagt aatcagatcg tttgtaagtt tcactgtatt ctaaaacttg   2118480
gccagttgat tcgagtttgg tgattttagt ttgtaggaca gtagggaatt gttcatcgac   2118540
tccgaggact gaagctgcat gttctggagt tggaaagact atttcgttga tttcttcaaa   2118600
gtgttcatca ttcatgtgaa tgtggtagtc taacttgaaa cgattataga tagaactata   2118660
gtattcaagg tttggataat ttgcgttgat atattgttct gggatgtagg atgtatggta   2118720
gatataaacg acaccgtttg attcgcggat acgttcaatc ttgtagtaga attgatcgcc   2118780
gcgtagaccc aatttttcca agtaaacaag cttgtttccg cgttcaattg aaagaacagt   2118840
taccttatca tctttagcat tgaagagttc aatatctgaa aactctacaa gcttgtgttt   2118900
gcgtgcacgt gaaacgaagg ttccttttcc ttgttggcgg acaatatagc catctttggc   2118960
aaggtcgttt aaggcgcgaa caactgtgat agagctgaca tcgtacattg aaatgagttc   2119020
tgcttcagtg taaaatttat ctccactgct aaactgccca gagatgattt tattttttaa   2119080
ttcgtctttt atgtattgat atttgggaat tgccatattt ttacctctat tttccttctt   2119140
ccatagaaaa ttttaccata aaagcgaaaa aaatagtagt cttttgaata aaaaattaga   2119200
ataatagttt gaaaaattaa gcgatatagg gattgctcat attttataaa tgtattctat   2119260
acaaaattat tttaggtcct atattccgaa tttaaagagc gtttgaaatg ggtctaaaaa   2119320
tgtttgaaac taattgaatg tgtgtataat agtaaaaatg cagtaaatat cccgacaatt   2119380
tctattgaca attcaaacag attggtttat aattaatata acaacaaatg aaagcgcaaa   2119440
ctttcgcggt cggaaggtag ttttatgaca cgatttgaga tacgagatga tttctatctc   2119500
gatggaaaat catttaagat tttatctggt gccattcatt attttagggt tcctccagag   2119560
gattggtatc attcgctcta taacttgaag gctcttggtt ttaatacggt agagacttat   2119620
gttgcttgga atttacacga gccttgtgaa ggtgagtttc attttgaagg tgatctggat   2119680
ttagagaaat ttctccaaat agcgcaggat ttgggtctct acgcaattgt gcgtccgtct   2119740
ccatttatct gtgcggaatg ggaattcggt ggcttaccag cttggctctt gaccaagaac   2119800
atgcgaattc gctcatccga cccagcatat atcgaggcag ttggtcgcta ctatgatcag   2119860
ttattgccaa gactggtgcc tcgtttgttg gacaatggtg gcaatattct catgatgcag   2119920
gttgaaaatg agtatggttc ttacggagaa gataaggctt acctgagagc gattcgacag   2119980
ctaatggaag agtgtggcgt aacctgtccc ctctttacat cagatggtcc atggcgagct   2120040
actctgaaag ctggaacctt aattgaagag gacctctttg taacaggaaa ctttggttct   2120100
aaggcacctt acaacttttc gcagatgcag gaattctttg atgaacatgg taagaaatgg   2120160
ccactcatgt gtatggagtt ctgggatggt tggttcaatc gctggaaaga accgattatc   2120220
acacgggatc ctaaggaatt ggcagatgca gttcgagagg ttttggaaca aggctctatc   2120280
aatctttaca tgttccacgg tggtacaaac tttggtttca tgaatggttg ctcagctcga   2120340
ggaactttgg acctgccaca agttacgtct tatgattacg atgcccttct ggatgaagaa   2120400
ggaaatccaa ctgctaaata tcttgcagtc aagaagatga tggcaacaca tttttcagag   2120460
tatccgcagt tggaaccact ctacaaagag agtatggagt tggatgctat tccactagtt   2120520
gaaaaagttt ctttgtttga aaccttagat agcttgtcaa gtcctgtaga aagtctctat   2120580
cctcaaaaga tggaggagct gggacaaagt tatggctacc tactttatcg aacagaaaca   2120640
aactgggatg cagaagaaga aagacttcgt atcattgatg gtcgagatag ggcccagctg   2120700
tatgtcgatg gtcagtgggt taaaactcaa tatcagacag agattgggga agatattttt   2120760
tatcaaggta aaaagaaagg gctatctagg ttagatatct tgatagaaaa tatggggcgt   2120820
gtcaactatg ggcataagtt cttagcggat acgcaacgta agggaattcg gacaggggtc   2120880
tgtaaggatc tgcatttctt actaaactgg aaacactatc cactcccact agacaatcct   2120940
gagaaaattg atttttcaaa aggatggact caaggacaac cagcctttta cgcttatgac   2121000
tttacagtcg aagagccaaa agatacttac ctagacttgt ctgagtttgg taagggggtt   2121060
gcctttgtca atgggcagaa tctaggacgt ttttggaacg ttggcccaac tctctcactt   2121120
tatatccctc atagctatct caaggaaggt gccaaccgca tcattatctt tgaaacagaa   2121180
ggtcaatata aagaagagat tcatttaact cgtaaaccta cactaaaaca tataaagggg   2121240
gaaaacttat gacaattgta ggatgccgta ttgatggacg tttgatccac ggacaagtag   2121300
ccaatctttg ggctggaaaa ctaaatgttt cacgcattat ggttgtagac gacgaagttg   2121360
tcaacaacga tattgaaaag agtggtttga aacttgcgac accaccaggt gtgaaattga   2121420
gtattttgcc agttgagaaa gctgcagcca atattcttgg tggcaaatac gatagccaac   2121480
gtctctttat cgtggctcgt aaaccagacc gcttccttgg tttggtagaa gcaggtgtac   2121540
cacttgaaac ccttaatgtt gggaatatgt ctcaaacacc agaaactcgt tctattacac   2121600
gttctatcaa cgtagtagac aaggatgtgg aagacttcca caaactggca gaaaaaggtg   2121660
ttaaacttac tgctcagatg gttccaaatg atccaatttc agactttttg agcttattaa   2121720
aataggaaaa aaatttttag gaggtcattg ttatgataca atggtggcaa attttacttc   2121780
tcactttgta ctcagcttat caaatctgtg atgagttgac gatcgtttca tctgcaggtt   2121840
cccctgtatt tgctggtttc attactggtt taatcatggg agatgtgact actggtttac   2121900
ttatcggtgg taacttgcaa ctgttcgttc ttggggttgg taccttcggt ggtgcttctc   2121960
gtatcgacgc aacttctggt gcggttcttg cgacagcctt ctctgtttca caaggaattg   2122020
atgcaccgct tgccattact acaatcgctg taccagtagc agctctcttg acttacttcg   2122080
acgttcttgg tcgtatgact actaccttct tcgctcaccg tgtggatgct gcaatcgaac   2122140
gctttgacta taaaggtatt gaacgcaact acttgcttgg tgcgattccg tgggctctat   2122200
ctcgtgccct tccagtcttc tttgcccttg cttttggtgg tgcctttgta caatcagtag   2122260
tagacttcgt tgaagcctac aaatgggttg cagatggctt gacacttgca ggacgtatgc   2122320
ttccaggtct tggatttgca atcttgcttc gttaccttcc agttaaacgt aaccttcact   2122380
accttgctat gggatttggt ttgacagcta tgttgactgt tctttactca tatgtaacag   2122440
gtcttggtgg cgctgttgct ggtatcgtag gtactcttcc tgctgaagtt gctgaaaaaa   2122500
ttggtttcgt gaacaacttc aaaggtttgt ctatgattgg tatttctatc gtaggtattt   2122560
tccttgcagt gcttcacttc aaaaatagcc aaaaagtagc tgtagcagca ccttctacac   2122620
catcagaaag tggggaaatc gaagatgacg aattctaatt acaaacttac aaaagaagat   2122680
tttaatcaaa tcaacaaacg tagcttgttt actttccaat taggttggaa ctacgaacgt   2122740
atgcaagctt ctggttacct ttacatgatc ttgcctcagt tgcgtaaaat gtatggtgat   2122800
ggaactcctg aattgaaaga aatgatgaaa gttcatactc aattcttcaa tacttcacca   2122860
ttcttccata ccattatcgc tggttttgac cttgccatgg aagaaaaaga tggtgtaggt   2122920
tcaaaagacg ccgttaacgg tatcaagaca ggtttgatgg gaccattcgc tcctcttggg   2122980
gatacaatct ttggttcact tgtacctgct atcatggggt cagtcgcagc aactatggct   2123040
atcgctggcc aaccttgggg gatcttcctt tggattgcag ttgcagtagc gtatgacatc   2123100
ttccgttgga aacagttgga atttgcttac aaagaagggg ttaaccttat caacaacatg   2123160
caaagtacct tgacagcttt gattgacgct gcatctgtac ttggtgtctt catgatgggt   2123220
gctcttgtag caacagtgat taactttgaa atttcttaca agttgccaat cggtgaaaag   2123280
atgattgatt tccaagacat cttgaaccaa atcttcccac gtttgcttcc agcaatcttt   2123340
actgccttta tcttctggtt gcttggtaag aaaggtatga actctactaa agctatcggt   2123400
attattatcg tacttgcttt ggctctttct gcccttggtc actttgcact tggaatgtaa   2123460
ttccttatga ctaaatcatt aattttggtg agccatggtc gcttctgtga ggagcttaga   2123520
ggtagcacag aaatgattat gggcccacaa gacaacattt acacagtagc tcttcttcca   2123580
gaagatggcc cagaagaatt tactgctaaa tttgaagctg ttattgaagg attggatgat   2123640
ttcctagtct ttgcggatct tctcggtggg acaccttgta atgtggtgag tcgcttgatc   2123700
atggaaggtc gtgatattga cctttacgca gggatgaatc ttccaatggt gattgaattt   2123760
atcaatgcga gccttacagg cgcagatgcg gactacaaga gccgtgctgc agaaagcatt   2123820
gtgaaagtta atgacctgtt agcgggcttc gatgatgacg aagatgaata atactcttcg   2123880
aaaatctctt caaactacgt caacgtcgcc ttgccgtagg tatatgttac tgacttcgtc   2123940
agtcttatcc ggcaacctca aaacggtgtt ttgagctgac ttcgtcagtc ttatccggca   2124000
acctcaaagc agtgctttga gcagcctgcg gctagtttcc tacagatttt agttggaact   2124060
cgattcaatt catgtgacaa cgtgaaaatc gttagagcat tttatataga atatacatgg   2124120
gaatgtagct tactcccatt cccatattta atagaaaaag aggaactcaa tgctacatta   2124180
tacaaaagaa gacttgctcg aattgggtgc agaaatcact acgcgtgaaa tctaccaaca   2124240
gcctgatgta tggagagaag cttttgaatt ttatcaagca aaacgtgaag aaattgcagc   2124300
cttcctacaa gaaatcgctg ataaacatga ctatattaag gttatcttga caggtgctgg   2124360
gacttctgct tatgtgggag ataccttgct accttatttt aaggaagtct atgacgaacg   2124420
caaatggaat ttcaatgcta ttgcgacaac agatatcgtt gccaatccag caacctattt   2124480
gaaaaaagat gtggcaactg tccttgtgtc ttttgctcgt agtgggaatt cgcctgaaag   2124540
tttggcgact gttgatttgg ccaaatcctt ggtggatgag ctttatcaag tgacgattac   2124600
ttgtgcagca gatggtaaat tggctcttca agctcacggt gatgatcgta atctcttgct   2124660
cttgcaacca gctgtctcta atgatgctgg atttgccatg acttctagct ttacgtctat   2124720
gatgttgaca actctcttgg tctttgatcc tacagaattt gctgttaagt ctgaacgttt   2124780
tgaagttgta tctagtcttg cccgtaaagt tttagacaag gcagaagatg tcaaagagct   2124840
cgttgattta gactttaacc gtgtcatcta tctaggcgct ggtcctttct ttggacttgc   2124900
tcatgaagct cagctcaaga ttttggaatt aactgctggt caagttgcga ccatgtatga   2124960
aagcccagtt ggcttccgtc acggtccaaa atctcttatc aacgacaata cagttgtttt   2125020
ggtctttggt acaacgacag actacactcg taagtacgac ttggacttgg ttcgtgaagt   2125080
tgctggtgac cagattgctc gtcgtgttgt gcttttgagt gatcaagctt ttggtcttga   2125140
aaatgtcaaa gaagtggccc ttggttgtgg cggtgtcttg aatgatattt accgtgtctt   2125200
cccttacatc gtttatgccc aactctttgc tttattgact tcactcaagg tagaaaataa   2125260
accagataca ccgtctccta caggtacagt aaaccgtgta gtacaaggtg tcataattca   2125320
cgaatatcaa aagtaagaca gtgtttatga attcttgaca agaggatttg taaattatca   2125380
gataaaccat agattgtcag tacgctttct atggtttgtt tgcttgagag aaatagtaaa   2125440
aggagaacag aatgaaagca tacacagagc gtgtatttgg aaatgttgag ggtgaggatg   2125500
tcttggccta tcgatttgag acagacggtg gctaccaact tgaggttatg acttatggtg   2125560
cgactatctt gcgctatgtc gcacctgaca aggctggaaa ttttgccaat gttatcttgg   2125620
gatttgatga ctttgatagt tatgtaggca atagtcccaa gcatggagca agtgtaggtc   2125680
ctgtagcggg tcgtattgca ggtgcgacct ttgagctcaa tggtaagacc tatgaccttg   2125740
aggttaataa tgctagcaac tgtaatcaca gtggttcaac tggttgggat tccagcttgt   2125800
ttgaagttga agaagtaagc gatcatggct tgactctcta cacagagcgt acagatggga   2125860
caggagggtt ccctggaaat ctcaagattt ggatcagtta tcacttggaa gaaactggtg   2125920
cctatgaaat cagctacaag gtaacgaccg atcaggatac gctggtcaat ccaaccaacc   2125980
acagctattt caacttgtct ggtgatttca cgcagacgat tgaccgtcat gtcttccaac   2126040
taaacacaga gggcatttac tcaatcgctc ctgacggtgt tcctgccaaa actccagaag   2126100
ccaaccgtga tgtggtcaaa cacgtctaca atggtacctt gttgaaggat atctttgcag   2126160
aagaagatga gcaaatccag ctggcatcag gtttggatca tccatttgcc cttcctgcag   2126220
gccatgacaa tgctggattc ctttatgacc aaaattcagg tcgcttcctg cttttcaaga   2126280
cagaagctcc ttgctttgtg gtctacacag caaactttgt ggatgaaagt gtcatcatag   2126340
gaggtcagcc aatgctacag cacaatggga ttgctcttga agcgcaagct ttaccagatg   2126400
ccattcacag tgaccttaaa ggccaagtca ttcttaaagc tggtcaaacc ttcaccagta   2126460
agacacgtta tgaacttgtt gtgaagtaaa agagtcattg cgcctacttt tgggagctag   2126520
gaataggtac gcagagacaa atagtaggaa aatatgatat aactaagcgt tgaaagctat   2126580
ctgttaatat aatattcaaa ctacaataag gagtaagaaa gaaacgaaga aaattgtatt   2126640
tgctagtgcc ttggctttga ccttggctgg agcagttttg acaaatgatg tttttgcgaa   2126700
cgacagactt gtggcaacac aaactactga tggtaaaaat gaaaatgtat tgacctcaga   2126760
ggtgctaaaa ccttctagtg gcaatgtttt ggttggaatc aaaggagaat ttgtggctcc   2126820
tcatcaacaa tctattttgg atgccatcaa tgctatctgt aaagaagcgg ctgacgaagg   2126880
tttggtagat aagtatgtcc ctatcaaatg atcaactgac ctagaaaagg cagcttttgc   2126940
cagagctaca gaagcatcta taaccatgga tcatacccgt ctttctagca aagatctttg   2127000
gagtgccttt ccaacttcta atagtataat gggagaaaat ttggcatgga atcatgacgg   2127060
ttttctaaaa gctattgaac aatggcgtgc tgaaaaagca gattatgtgg agaaaaaaat   2127120
agtggttcag acaacgggaa atctggtcac tatgagtcgc taattaaccc taaatttaca   2127180
cacatgggga tggcagcttt taaaaatcct aacaatcaat acaaagctat tacaattgct   2127240
caaactctag gtgatgatgc ttcttcagag gaattggctg gtagatatgg ttctgctgtt   2127300
cagtgtacag aagtgactgc ctcaaacctt tcaacagtta aaactaaagc tacggttgta   2127360
gaaaaaccac tgaaagattt tagagcgtct acgtctgatc agtctggttg ggtggaatct   2127420
aatggtaaat ggtatttcta tgagtctggt gatgtgaaga caggttgggt gaaaacagat   2127480
ggtaaatggt actatttgaa tgacttaggt gtcatgcaga ctggatttgt aaaattttct   2127540
ggtagctggt attacttgag caattcaggt gctatgttta caggctgggg aacagatggt   2127600
agcagatggt tctactttga cggctcagga gctatgaaga caggctggta caaggaaaat   2127660
ggcacttggt attaccttga cgaagcaggt atcatgaaga caggttggtt taaagtcgga   2127720
ccacactggt actatgccta cggttcagga gctttggctg tgagcacaac aacaccagat   2127780
ggttaccgtg taaatggtaa tggtgaatgg gtaaactagg ctcaggccat aggtaaagca   2127840
ttcatcttac ttagcaaaaa gaatgaacga taagaaagag gttgatggcg aacattggcc   2127900
tcttttgatt tataaagatt ggattcttgt cgcctcaatt tcagactttt ctattgtaag   2127960
ctaatatttt atagcccatt aaaagcataa gcggtaatct aatttaaaaa atgctgtaat   2128020
tagtctgaag tccacactta cttgttgaga tgttatctct gttttttatc gttataattt   2128080
actgtatttt ttatagtatg cagaatattt ttaagtatat ttcaatagaa atttctatcg   2128140
atttattgta taatgataag taattgttga aaagtactca gaaaattcca tactatatta   2128200
tttttatgtt tatactttta tgctataaaa tatagattga tataaagaat atagaaaaag   2128260
cgaggttaat atgagccgaa aaagcattgg tgagaaacgc catagtttct cgatgagaaa   2128320
gttgtcagtg ggattggtat cagttactgt atctagtttc tttttgatga gtcaagggat   2128380
tcaatcggta tcggccgata atatggaaag tccaattcat tataagtata tgaccgaggg   2128440
taaattgaca gacgaggaaa aatccttgct ggtagaggcc cttccacaac tggctgaaga   2128500
atcagatgat acttattact tggtttatag atctcaacag tttttaccga atacaggttt   2128560
taacccaact gttggtactt tcctttttac tgcaggattg agcttgttag ttttattggt   2128620
ttctaaaagg gaaaatggaa agaaacgact tgttcatttt ctgctgttga ctagcatggg   2128680
agttcaattg ttgccggcca gtgcttttgg gttgaccagc cagattttat ctgcctataa   2128740
tagtcagctt tctatcggag tcggggaaca tttaccagag cctctgaaaa tcgaaggtta   2128800
tcaatatatt ggttatatca aaactaagaa acaggataat acagagcttt caaggacagt   2128860
tgatgggaaa tactctgctc aaagagatag tcaaccaaac tctacaaaaa catcagatgt   2128920
agttcattca gctgatttag aatggaacca aggacagggg aaggttagtt tacaaggtga   2128980
agcatcaggg gatgatggac tttcagaaaa atcttctata gcagcagaca atctatcttc   2129040
taatgattca ttcgcaagtc aagttgagca gaatccggat cacaaaggag aatctgtagt   2129100
tcgaccaaca gtgccagaac aaggaaatcc tgtgtctgct acaacggtgc agagtgcgga   2129160
agaggaagta ttggcgacga caaatgatcg accagagtat aaacttccat tggaaaccaa   2129220
aggcacgcaa gaacccggtc atgagggtga agccgcagtc cgtgaagact taccagtcta   2129280
cactaagcca ctagaaacca aaggtacaca aggacccgga catgaaggtg aagctgcagt   2129340
tcgcgaggaa gaaccagctt acacagaacc gttagcaacg aaaggcacgc aagagccagg   2129400
tcatgagggc aaagctacag tccgcgaaga gactctagag tacacggaac cggtagcgac   2129460
aaaaggcaca caagaacccg aacatgaggg cgaagcggca gtagaagaag aacttccggc   2129520
tttagaggtc actacacgaa atagaacgga aatccagaat attccttata caacagaaga   2129580
aattcaggat ccaacacttc tgaaaaatcg tcgtaagatt gaacgacaag ggcaagcagg   2129640
gacacgtaca attcaatatg aagactacat cgtaaatggt aatgtcgtag aaactaaaga   2129700
agtgtcacga actgaagtag ctccggtcaa cgaagtcgtt aaagtaggaa cacttgtgaa   2129760
agttaaacct acagtagaaa ttacaaactt aacaaaagtt gagaacaaaa aatctataac   2129820
tgtaagttat aacttaatag acactacctc agcatatgtt tctgcaaaaa cgcaagtttt   2129880
ccatggagac aagctagtta aagaggtgga tatagaaaat cctgccaaag agcaagtaat   2129940
atcaggttta gattactaca caccgtatac agttaaaaca cacctaactt ataatttggg   2130000
tgaaaataat gaggaaaata ctgaaacatc aactcaagat ttccaattag agtataagaa   2130060
aatagagatt aaagatattg attcagtaga attatacggt aaagaaaatg atcgttatcg   2130120
tagatattta agtctaagtg aagcgccgac tgatacggct aaatactttg taaaagtgaa   2130180
atcagatcgc ttcaaagaaa tgtacctacc tgtaaaatct attacagaaa atacggatgg   2130240
aacgtataaa gtgacggtag ccgttgatca acttgtcgaa gaaggtacag acggttacaa   2130300
agatgattac acatttactg tagctaaatc taaagcagag caaccaggag tttacacatc   2130360
ctttaaacag ctggtaacag ccatgcaaag caatctgtct ggtgtctata cattggcttc   2130420
agatatgacc gcagatgagg tgagcttagg cgataagcag acaagttatc tcacaggtgc   2130480
atttacaggg agcttgatcg gttctgatgg aacaaaatcg tatgccattt atgatttgaa   2130540
gaaaccatta tttgatacat taaatggtgc tacagttaga gatttggata ttaaaactgt   2130600
ttctgctgat agtaaagaaa atgtcgcagc gctggcgaag gcagcgaata gcgcgaatat   2130660
taataatgtt gcagtagaag gaaaaatctc aggtgcgaaa tctgttgcgg gattagtagc   2130720
gagcgcaaca aatacagtga tagaaaacag ctcgtttaca gggaaactta tcgcaaatca   2130780
ccaggacagt aataaaaatg atactggagg aatagtaggt aatataacag gaaatagttc   2130840
gagagttaat aaagttaggg tagatgcctt aatctctact aatgcacgca ataataacca   2130900
aacagctgga gggatagtag gtagattaga aaatggtgca ttgatatcta attcggttgc   2130960
tactggagaa atacgaaatg gtcaaggata ttctagagtc ggaggaatag taggatctac   2131020
gtggcaaaac ggtcgagtaa ataatgttgt gagtaacgta gatgttggag atggttatgt   2131080
tatcaccggt gatcaatacg cagcagcaga tgtgaaaaat gcaagtacat cagttgataa   2131140
tagaaaagca gacagattcg ctacaaaatt atcaaaagac caaatagacg cgaaagttgc   2131200
tgattatgga atcacagtaa ctcttgatga tactgggcaa gatttaaaac gtaatctaag   2131260
agaagttgat tatacaagac taaataaagc agaagctgaa agaaaagtag cttatagcaa   2131320
catagaaaaa ctgatgccat tctacaataa agacctagta gttcactatg gtaacaaagt   2131380
agcgacaaca gataaacttt acactacaga attgttagat gttgtgccga tgaaagatga   2131440
tgaagtagta acggatatta ataataagaa aaattcaata aataaagtta tgttacattt   2131500
caaagataat acagtagaat acctagatgt aacattcaaa gaaaacttca taaacagtca   2131560
agtaatcgaa tacaatgtta caggaaaaga atatatattc acaccagaag catttgtttc   2131620
agactataca gcgataacga ataacgtact aagcgacttg caaaatgtaa cacttaactc   2131680
agaagctact aaaaaagtac taggagcagc gaatgatgca gccttagata acctatactt   2131740
agatagacaa tttgaagaag ttaaagctaa tatagcagaa cacctaagaa aagtattagc   2131800
gatggataaa tcaatcaata ctacaggaga cggtgtagtt gaatacgtaa gtgagaaaat   2131860
caaaaataac aaagaagcat ttatgctagg tcttacttat atgaaccgtt ggtacgatat   2131920
taattatggt aaaatgaata caaaagattt atctacgtac aagtttgact ttaacggaaa   2131980
taatgagact tcaacgttgg atactattgt cgcattagga aatagtggac tagataacct   2132040
gagagcttca aatactgtag gtttatatgc gaataaactt gcatcggtaa aaggagaaga   2132100
ttcagtcttt gacttcgtag aagcgtatag aaaactgttc ttaccaaaca aaacaaataa   2132160
cgagtggttt aaagaaaata caaaggcata tatagtcgaa atgaagtctg atattgcaga   2132220
agtacgagaa aaacaagaat caccaacagc cgatagaaaa tattcattag gagtttacga   2132280
tagaatatca gcaccaagtt gggggcataa gagtatgtta ttaccactac taactttacc   2132340
tgaagaatct gtgtatattt catcgaatat gtctacactt gcattcggtt cgtatgaaag   2132400
atatcgtgat agtgtggatg gagttattct ttcaggagat gctttacgaa cttatgtaag   2132460
aaatagagtt gatatagcag cgaaaaggca tagagaccat tatgatattt ggtacaatct   2132520
tcttgacagt gcttcaaaag aaaaactttt ccgttctgtg atagtttatg atggattcaa   2132580
tgtaaaagat gagacaggaa gaacttattg ggcaaggtta acggataaaa acatcggctc   2132640
tattaaagaa ttcttcggac ctgttgggaa atggtatgag tataatagta gtgcaggagc   2132700
gtatgcgaat ggaagtttaa cgcactttgt gttagataga ttattagatg cttatggaac   2132760
gtcggtttat actcatgaaa tggttcataa ttctgattct gcaatctact ttgaaggaaa   2132820
tggtagacgt gaaggattgg gagcggagtt atacgcactt ggtttactgc aatctgtaga   2132880
tagtgtaaat tctcatattt tagctttaaa tacgttatat aaagcagaaa aagatgattt   2132940
gaatagattg catacatata atccggtgga acgtttcgat tcggatgagg cgcttcaaag   2133000
ttatatgcat ggatcatatg atgtaatgta tacacttgat gcgatggaag caaaagcgat   2133060
attagctcaa aataatgatg ttaagaaaaa atggtttaga aaaatagaaa attattacgt   2133120
tcgtgatact agacataata aagatacaca tgcaggaaat aaagtccgtc cattaacaga   2133180
tgaagaagta gctaacttaa catcgttaaa ctcattaatc gacaacgaca tcataaatag   2133240
acgtagctat gatgatagta gagaatataa acgaaatggc tactatacta taagtatgtt   2133300
ctctcctgta tacgcagcgc taagcaattc gaaaggtgct cctggagata ttatgtttag   2133360
aaaaatagct tatgaattac ttgcggaaaa aggttatcac aaaggattcc taccttatgt   2133420
ttctaatcag tacggagcag aagcatttgc cagcggaagc aaaacattct catcatggca   2133480
tggaagagat gttgctttag tgacagatga tttagtattt aagaaagtat tcaatggtga   2133540
gtactcatca tgggctgatt tcaaaaaagc aatgtttaaa caacgtatag ataaacaaga   2133600
taatctgaaa ccaataacaa ttcaatacga attaggtaat cctaatagta caaaagaagt   2133660
aactataaca acggctgcac aaatgcaaca attaattaat gaagcggctg cgaaagatat   2133720
tactaatata gatcgtgcaa cgagtcatac cccagcaagt tgggtgcatt tattaaaaca   2133780
aaaaatctat aatgcatatc ttcgcactac agatgacttt agaaattcta tatataaata   2133840
agattgtaga gtttcattgt tgagtagtgt ttcttgtaag gatgaggagt cagatgacaa   2133900
atcgactcct ttttcttatg gatcgatgta gagatttgat tgaatgcaga ttgcaggaat   2133960
catcttcaac tcatcaacga ccaatggtga caaggtggat ttcaatccca cagaaaatgt   2134020
tgatttgaga aataactttg ctagtctagt aaaataaata caaaacaatc ctagaagatt   2134080
ttttctggga ttgttttttg ctgagtggga tgcttcaagt tgtctggctt gactttcttg   2134140
agggaagtta tataatagtt gtaataatta aagttacaat aaaagaggaa atatttatga   2134200
catatgaata ccagagccac atttatttag cagaggcagt tttaaatgtg aaggatttgg   2134260
tcagtcaaac agttttttat cagcagatta ttggtttaga aatcctatct caaacggata   2134320
cagaggtcgt tctgggactt ggaggaaaag ccttggtaca cttgattcaa gcacaagagg   2134380
gtggagaagt aagggaacat tatggtcttt accatctggc tattcttttg ccgacacgaa   2134440
aggctttggc ggatgtcttg aagcacctga cggatttaca gattcctctt gttggcggtg   2134500
cagatcacgg ttacagtgag gccctttact tagaggactt ggagggaaat ggcattgaac   2134560
tctatcgaga taagccagtt tccacatggg atattcgaga agatggacgt attatcgggg   2134620
tgactgaagt ccttgcggct caggatatct atgagttggg ggaaagagta gagcctttta   2134680
tcctagcaga gggtacgaga atggggcata ttcatctttc tgtcaaggat agtcgaaagt   2134740
ccagacagtt ttatcaaacg gtgttagggc tcgaggataa attcagtgtg cctagtgcta   2134800
gttggatcgc agctggggac taccatcatc atttagcagt caacgaatgg ggaggaaaag   2134860
gtctggatcc gcgtaaacaa gtcctaccag gtttagccta ctatgtcatc gaagtcgcac   2134920
ataaagaaga actgttaacg attgcccaac gagcacaaga agttgacgca ccaatcaaat   2134980
ggatgacatc gatccaattg gaaatcacag actcagatgg catcgtgacc cgtattcgtt   2135040
tagctagata gatggtatgt gatgaaggta gagcatcaat tgtagaaagt gctccttatt   2135100
ctagtcagat acgtggaaaa tttgatatga tagtagggaa taaggagaag aataatatga   2135160
ctagcgaata ccagaaaatg atagcaggag agttttaccg tccatcagac ccagaactga   2135220
gagccttagc tcaggcttct cgccaaaaac aggccgcctt taacaaggaa gagaacccct   2135280
tgaagggagc cgaaatcatc aagacttggt ttgcctcaac cgggaaaaat ctttacatca   2135340
acactcgctt gatggtggac tacggtgtca acatccatct aggggaaaat ttttattcta   2135400
attggaactt gaccatgctg gatatctgtc ccattcgtat cggggacaat gctatgattg   2135460
gtcctaattg tcagtttttg acacccctcc atccactaga tccacaggaa cgcaattcag   2135520
gtatcgagta cggaaagcct atcacaatcg gagataattt ctggactggt ggtggcgtca   2135580
ttgtccttcc tggagtgaca ctgggaaata atgtcgttgc aggagcaggg gcagtaatta   2135640
ccaaatcttt tggcgacaac gttgtcctag ctggcaatcc tgcgcgcgtg attaaggaaa   2135700
tacctgttaa atagaagtaa aaaggaacag ctggggttgt ttcttttttg taggtttcat   2135760
cattttttac ccagttcaca tttacctact ctatctctta gcaagtctgt ttcattaagc   2135820
aagttcaaag catctcgtaa gtgggatgtt tttctcctca gttcatcagc ttcctccttg   2135880
acactcggtc agattttgat acaatagtac aaaattagag gaggcaggct atgattcaga   2135940
aacatgcgat tcctatttta gagtttgatg acaatcctca ggcggttatc atgcccaatc   2136000
acgaggggct ggacttgcag ttgccaaaga agtgtgttta tgcattttta ggtgaggaga   2136060
ttgaccgcta tgcgagggaa gtaggggcga actgtgttgg cgaatttgtt tctgccacca   2136120
agacctatcc agtttatgtc gtgaactaca aggacgagga ggtctgtctg gctcaggctc   2136180
ctgttggctc cgctccagca gcccagttta tggattggtt gattggctat ggtgtggagc   2136240
agattatctc tactgggacc tgtggtgtcc tagctgatat agaggaaaat gcctttctag   2136300
tccctgttcg cgctctgcga gatgaaggag ccagttacca ctatgtggca ccttgtcgtt   2136360
atatggaaat gcagccagag gctattgctg ctattgagga agttttggaa gacagaggga   2136420
ttccttatga agaagtcatg acctggacga cagacggttt ttaccgagaa acggctgaaa   2136480
aggtggctta tcgtaaggaa gaaggctgtg ctgttgtgga gatggagtgt tctgctcttg   2136540
cggcagtagc tcaattgcgt ggggttctct ggggtgaatt gttgttcaca gcagattctc   2136600
tagcggactt ggaccagtac gacagtcgtg actggggctc ggaagctttt aataaggcgc   2136660
tagaactgag tttagcaagt gttcaccacc tttagttgta ctggcaaagg atttgtttta   2136720
tcataaaatg tctagctcat acttttcaaa aatatgttta aacgaggtca ccttcctctt   2136780
gtcctaggca tgttgaggtt gggaaaaatc tttaaaatca gaaaaacgta tcatatcagg   2136840
tgatgaaaac tttgacacta tgcgttttat gtcgataaga tttagagtga gatgaaatga   2136900
tactcttcga aaatctcttc aaaccaggtc agcttcacct tgccgtaggt atatgttact   2136960
gacttcgtca gtcttatccg gcaacctcaa aacggtgttt tgagctgact tcgtcagttc   2137020
tatttgcaac ctcaaaacag tgttttgagc aacctgtgac tagctttcta atcgatgcct   2137080
tggttttcat tgcctataat caaaaagaga aattttctcc tgaaaagcat atagagtagc   2137140
tggcgttaaa agctcctgtc ttgctttttt gacctatagt cacatctatc aagtattgtt   2137200
cttgcctaag ctatcaataa aaaggtggca ttttttaggc ttggtgttag tagattttgc   2137260
cttatcctat ctaagtcatt tcgaactttt tatggtacaa tggaaacatg ttattcaaat   2137320
tatctaagga aaaaatagag ctaggcttat ctcgtttatc gccagcccgt cgtatttttt   2137380
tgagttttgc cttggtcatt ttactaggct ctcttctttt gagcttgccc tttgtccaag   2137440
ttgaaagctc acgagcgact tattttgatc atcttttcac tgctgtctct gcagtctgtg   2137500
tgacgggtct ctcaaccctt ccagtagctc acacctataa tatctggggt caaataatct   2137560
gtttgctctt gattcagatc ggtggtctag ggctcatgac ctttattggg gttttctata   2137620
tccagagcaa gcaaaagctt agtcttcgta gccgtgcaac tattcaggat agttttagtt   2137680
atggagaaac tcgatctttg agaaagtttg tctattctat ttttctcacg acctttttgg   2137740
ttgagagctt gggagctatt ttgcttagtt ttcgccttat tcctcaactt ggctggggac   2137800
gtggtctttt tagttccatt tttctagcga tctcagcctt ctgtaatgcc ggttttgata   2137860
atttagggag caccagttta tttgcttttc agaccgattt actggtcaat ctggtgattg   2137920
caggcttgat tattacaggc ggccttggtt ttatggtctg gtttgatttg gctggtcatg   2137980
taggaagaaa gaaaaaagga cgtctgcact ttcatacgaa gcttgtacta ttattgacta   2138040
taggtttgtt gttatttgga acagcaacta ctctctttct tgagtggaac aatgctggaa   2138100
cgattggcaa tctccctgtt gccgataagg ttttagttag cttttttcaa acagtgacga   2138160
tgcgaacagc tggcttttct acgatagatt atactcaggc tcatcctgtg actcttttga   2138220
tttatatctt acagatgttt ctaggtgggg cacctggagg aacagctggg ggactcaaga   2138280
ttacgacatt ttttgtcctc ttggtctttg cacgaagtga gcttctaggc ttgcctcatg   2138340
ccaatgttgc gagacgaacg atcgcgccgc gaacggttca aaaatccttt agtgtcttta   2138400
ttatcttttt gatgagcttc ttgataggat tgattctgct agggataaca gccaaaggca   2138460
atcctccctt tatccacctc gtatttgaaa ccatttcagc tcttagtaca gttggtgtaa   2138520
cggcaaatct gactcctgac cttgggaaat tggctctcag tgttatcatg ccacttatgt   2138580
ttatgggacg aattggtccc ttgaccttgt ttgttagctt ggcagattac catccagaaa   2138640
agaaagatat gattcactat atgaaagcag atattagtat tggttaagaa aggaaagagc   2138700
atgtcagatc gtacgattgg aattttgggc ttgggaattt ttgggagcag tgtcctagct   2138760
gccctagcca agcaggatat gaatattatc gctattgatg accacgcaga gcgcatcaat   2138820
cagtttgagc cagttttggc gcgtggagtg attggtgaca tcacagatga agaattattg   2138880
agatcagcag ggattgatac ctgcgatacc gttgtagtcg cgacaggtga aaatctggag   2138940
tcgagtgtgc ttgcggttat gcactgtaag agtttggggg taccgactgt tattgctaag   2139000
gtcaaaagtc agaccgctaa gaaagtgcta gaaaagattg gagctgactc ggttatctcg   2139060
ccagagtatg aaatggggca gtctctagca cagaccattc ttttccataa tagtgttgat   2139120
gtctttcagt tggataaaaa tgtgtctatc gtggagatga aaattcctca gtcttgggca   2139180
ggtcaaagtc tgagtaaatt agacctccgt ggcaaataca atctgaatat tttgggtttc   2139240
cgagagcagg aaaattcccc attggatgtt gaatttggac cagatgacct cttgaaagca   2139300
gatacctata ttttggcagt catcaacaac cagtatttgg ataccctagt agcattgaat   2139360
tcgtaaagag ggatgacccc tcttttttga tgcctaagat ggcaaataga gacagaagcc   2139420
ccttgtcttc tagtaaaagt tcttcaaagg ctggacttta tggtaaaata gaaagaagtg   2139480
acaagagaga gtaatactca atgaaaatca aagatcaaac taggaaacta gctacgggct   2139540
gctcaaaaca ctgttttgag gttgcagata gaactgacga agtcagtaac atctatacgg   2139600
caaggcgacg ttgacgcggt ttgaagagat tttcgaagag tataagaaaa aatcagtccc   2139660
ctaaaggagt agattatgaa gttattgtct atcgcaattt ctagctataa tgcagcagcc   2139720
tatcttcatt actgtgtgga gtcgctagtg attggtggtg agcaagttgg gattttgatt   2139780
atcaatgacg ggtctcagga tcagactcag gaaatcgctg agtgtttagc tagcaagtat   2139840
cctaatatcg ttagagccat ctatcaggaa aataaatgcc atggcggtgc ggtcaatcgt   2139900
ggcttggtag aggcttctgg gcgctatttt aaagtagttg acagtgatga ctgggtggat   2139960
cctcgtgcct acttgaaaat tcttgaaacc ttgcaggaac ttgagagcaa aggtcaagag   2140020
gtggatgtct ttgtgaccaa ttttgtctat gaaaaggaag ggcagtctcg taagaagagt   2140080
atgagttacg attcagtctt gcctgttcgg cagatttttg gctgggacca ggtcggaaat   2140140
ttctccaaag gccagtatac catgatgcac tcgctgattt atcggacaga tttgttgcgt   2140200
gctagccagt tctaactgcc tgaacatact ttttatgtcg ataatctctt tgtctttacg   2140260
ccccttcagc aggtcaagac catgtactat ctgcctgtcg atttctatcg ttatttgatt   2140320
gggcgtgagg accagtctgt caatgagcaa gtgatgatta agtgcattga ccagcaactc   2140380
aaggtcaatc gactcttgat agaccaactt gatttgtccc aagtgagtca tcccaaaatg   2140440
cgagaatatc tgctgaatca tattgaactc acgacggtga tttccagtac cctgctcaac   2140500
cgatctggaa cagcggagca tctggcaaaa aaacgccaat tgtggaccta tattcagcag   2140560
aaaaatccag aagtctttca ggctattcgt aagaccatgt tgagccgttt gaccaaacat   2140620
tctgtcttgc cagatcgcaa actgtccaat gtcgtctatc aaatcaccaa atctgtttat   2140680
ggatttaatt aatataagtg ttttataaga gggatttaag aaaaatttta actttttctt   2140740
agtccttttt aatttcagga gattatacta gagtcatcaa ataaagaaag actctaagga   2140800
gaatcctatg aaattcaatc caaatcaaag atatactcgt tggtctattc gccgtctcag   2140860
tgtcggtgtt gcctcagttg ttgtggctag tggcttcttt gtcctagttg gtcagccaag   2140920
ttctgtacgt gccgatgggc tcaatccaac cccaggtcaa gtcttacctg aagagacatc   2140980
gggaacgaaa gagggtgact tatcagaaaa accaggagac accgttctca ctcaagcgaa   2141040
acctgagggc gttactggaa atacgaattc acttccgaca cctacagaaa gaactgaagt   2141100
gagcgaggaa acaagccctt ctagtctgga tacacttttt gaaaaagatg aagaagctca   2141160
aaaaaatcca gagctaacag atgtcttaaa agaaactgta gatacagctg atgtggatgg   2141220
gacacaagca agtccagcag aaactactcc tgaacaagta aaaggtggag tgaaagaaaa   2141280
tacaaaagac agcatcgatg ttcctgctgc ttatcttgaa aaagctgaag ggaaaggtcc   2141340
tttcactgcc ggtgtaaacc aagtaattcc ttatgaacta ttcgctggtg atggtatgtt   2141400
aactcgtcta ttactaaaag cttcggataa tgctccttgg tctgacaatg gtactgctaa   2141460
aaatcctgct ttacctcctc ttgaaggatt aacaaaaggg aaatacttct atgaagtaga   2141520
cttaaatggc aatactgttg gtaaacaagg tcaagcttta attgatcaac ttcgcgctaa   2141580
tggtactcaa acttataaag ctactgttaa agtttacgga aataaagacg gtaaagctga   2141640
cttgactaat ctagttgcta ctaaaaatgt agacatcaac atcaatggat tagttgctaa   2141700
agaaacagtt caaaaagccg ttgcagacaa cgttaaagac agtatcgatg ttccagcagc   2141760
ctacctagaa aaagccaagg gtgaaggtcc attcacagca ggtgtcaacc atgtgattcc   2141820
atacgaactc ttcgcaggtg atggcatgtt gactcgtctc ttgctcaagg catctgacaa   2141880
ggcaccatgg tcagataacg gcgacgctaa aaacccagcc ctatctccac taggcgaaaa   2141940
cgtgaagacc aaaggtcaat acttctatca agtagccttg gacggaaatg tagctggcaa   2142000
agaaaaacaa gcgctcattg accagttccg agcaaatggt actcaaactt acagcgctac   2142060
agtcaatgtc tatggtaaca aagacggtaa accagacttg gacaacatcg tagcaactaa   2142120
aaaagtcact attaacataa acggtttaat ttctaaagaa acagttcaaa aagccgttgc   2142180
agacaacgtt aaagacagta tcgatgttcc agcagcctac ctagaaaaag ccaagggtga   2142240
aggtccattc acagcaggtg tcaaccatgt gattccatac gaactcttcg caggtgatgg   2142300
tatgttgact cgtctcttgc tcaaggcatc tgacaaggca ccatggtcag ataacggtga   2142360
cgctaaaaac ccagccctat ctccactagg tgaaaacgtg aagaccaaag gtcaatactt   2142420
ctatcaatta gccttggacg gaaatgtagc tggcaaagaa aaacaagcgc tcattgacca   2142480
gttccgagca aacggtactc aaacttacag cgctacagtc aatgtctatg gtaacaaaga   2142540
cggtaaacca gacttggaca acatcgtagc aactaaaaaa gtcactatta acataaacgg   2142600
tttaatttct aaagaaacag ttcaaaaagc cgttgcagac aacgttaagg acagtatcga   2142660
tgttccagca gcctacctag aaaaggccaa gggtgaaggt ccattcacag caggtgtcaa   2142720
ccatgtgatt ccatacgaac tcttcgcagg tgatggcatg ttgactcgtc tcttgctcaa   2142780
ggcatctgac aaggcaccat ggtcagataa cggcgacgct aaaaacccag ctctatctcc   2142840
actaggtgaa aacgtgaaga ccaaaggtca atacttctat caagtagcct tggacggaaa   2142900
tgtagctggc aaagaaaaac aagcgctcat tgaccagttc cgagcaaacg gtactcaaac   2142960
ttacagcgct acagtcaatg tctatggtaa caaagacggt aaaccagact tggacaacat   2143020
cgtagcaact aaaaaagtca ctattaagat aaatgttaaa gaaacatcag acacagcaaa   2143080
tggttcatta tcaccttcta actctggttc tggcgtgact ccgatgaatc acaatcatgc   2143140
tacaggtact acagatagca tgcctgctga caccatgaca agttctacca acacgatggc   2143200
aggtgaaaac atggctgctt ctgctaacaa gatgtctgat acgatgatgt cagaggataa   2143260
agctatgcta ccaaatactg gtgagactca aacatcaatg gcaagtattg gtttccttgg   2143320
gcttgcgctt gcaggtttac tcggtggtct aggtttgaaa aacaaaaaag aagaaaacta   2143380
atcagctaag gaaataaatg atggatagtg ggctgactaa gattagttta acaactcaat   2143440
cagcaatcag gactttcttt caatagcaga ttaaaatcat cgtaaaacaa taaaaatagt   2143500
gttatactta aagcagtata gcactgtttt tatcaaagga gagacagatg ggaaagacaa   2143560
ttttactcgt tgacgacgag gtagaaatca cagatattca tcagagatac ttaattcagg   2143620
caggttatca ggtcttggta gcccatgatg gactggaagc gctagagctg ttcaagaaaa   2143680
aaccgattga tttgattatc acagatgtca tgatgcctcg gatggatggt tatgatttaa   2143740
tcagtgaggt tcaatactta tcaccagagc agcctttcct atttattact gctaagacca   2143800
gtgaacagga caagatttac ggcctgagct tgggagcaga tgattttatt gctaagcctt   2143860
ttagcccacg tgagctggtt ttgcgtgtcc acaatatttt gcgccgcctt catcgtgggg   2143920
gcgaaacaga gctgatttcc cttggcaatc taaaaatgaa tcatagtagt catgaagttc   2143980
aaataggaga agaaatgctg gatttaactg ttaaatcatt tgaattgctg tggattttag   2144040
ctagtaatcc agagcgagtt ttctccaaga cagacctcta tgaaaagatc tggaaagaag   2144100
actacgtgga tgacaccaat accttgaatg tgcatatcca tgctcttcga caggagctgg   2144160
caaaatatag tagtgaccaa actcccacta ttaagacagt ttgggggttg ggatataaga   2144220
tagagaaacc gagaggacaa acatgaaact aaaaagttat attttggttg gatatattat   2144280
ttcaaccctc ttaaccattt tggttgtttt ttgggctgtt caaaaaatgc tgattgcgaa   2144340
aggcgagatt tactttttgc ttgggatgac catcgttgcc agccttgtcg gtgctgggat   2144400
tagtctcttt ctcctattgc cagtctttac gtcgttgggc aaactcaagg agcatgccaa   2144460
gcgggtagcg gccaaggatt ttccttcaaa tttggaggtt caaggtcctg tagaatttca   2144520
gcaattaggg caaactttta atgagatgtc ccatgatttg caggtaagct ttgattcctt   2144580
ggaagaaagc gaacgagaaa agggcttgat gattgcccag ttgtcgcatg atattaagac   2144640
tcctatcact tcgatccaag cgacggtaga agggattttg gatgggatta tcaaggagtc   2144700
ggagcaagct cattatctag caaccattgg acgccagacg gagaggctca ataaactggt   2144760
tgaggagttg aattttttga ccctaaacac agctagaaat caggtggaaa ctaccagtaa   2144820
agacagtatt tttctggaca agctcttaat tgagtgcatg agtgaatttc agtttttgat   2144880
tgagcaggag agaagagatg tccacttgca ggtaatccca gagtctgccc ggattgaggg   2144940
agattatgct aagctttctc gtatcttggt gaatctggtc gataacgctt ttaaatattc   2145000
tgctccagga accaagctgg aagtggtggc taagctggag aaggaccagc tttcaatcag   2145060
tgtgaccgat gaagggcagg gtattgcccc agaggatttg gaaaatattt tcaaacgcct   2145120
ttatcgtgtc gaaacttcgc gtaacatgaa gacaggtggt catggattag gacttgcgat   2145180
tgcgcgtgaa ttggcccatc aattgggtgg ggaaatcaca gtcagcagcc agtacggtct   2145240
aggaagtacc tttaccctcg ttctcaacct ctctggtagt gaaaataaag cctaaaaccc   2145300
ctttacaaat ccagctattc atggtagaat agattttgtg tgaaatatca gcaggaaagc   2145360
atgaagctcg tcaacaggtg tcttatgaca agtaaccttg gctgtttagg cgaagggcat   2145420
ctgcacgaat cagggctttc taagtgacta tttccaccga aatattattt atatcaggag   2145480
gacattcata tgtcacgtta tacaggacca tcttggaaac aagctcgtcg tcttggcctt   2145540
tcacttacag gtacaggtaa agaattggca cgtcgtaact acgtaccagg acaacacgga   2145600
ccaaacaacc gttctaaatt gtcagaatac ggtttgcaat tggctgaaaa acaaaaactt   2145660
cgtttcactt acggtgtagg tgaaaaacaa ttccgtaact tgttcgtaca agctacaaaa   2145720
atcaaaggcg gaatcctagg tttcaacttt atgcttcttt tggaacgtcg tttggataac   2145780
gttgtttacc gtcttggtct cgcgactact cgtcgtcaag ctcgtcaatt cgtaaaccac   2145840
ggtcacatcc ttgttgacgg gaaacgcgtt gatatcccat cataccgcgt aactccaggt   2145900
caagtgatct cagttcgtga aaaatcattg aaagttccag caatccttga agcagtagaa   2145960
gctactcttg gacgtccagc attcgtatca ttcgacgctg aaaaattgga aggttcattg   2146020
actcgcttgc cagaacgcga cgaaatcaac ccagaaatca acgaagcact tgtcgttgaa   2146080
ttctacaaca aaatgttgta atattttatt gaataagata ggccttgata ttaagcactt   2146140
tgggacgttc tcccttagtg cttttttgat ttctcttagt atccagctat aatcgttgag   2146200
acataactag accgatatag tccaaagtga tatagtaaaa tgaaccaaaa atagtacaca   2146260
atgtggtata atccttttat ggcatattca atagattttc gtaaaaaagt tctctcttat   2146320
tgtgagcgaa caggtagtat aacagaagca tcacacgttt tccaaatctc acgtaatacc   2146380
atttatggct ggttaaagct aaaagagaaa acaggagagc taaaccacca agtatagtgt   2146440
attgaatcta taacagtaca ccttggctgc taaaatattt ctataaatta atttgacttt   2146500
cctgatagag atgttcacat cttatttcaa actactataa aagttctata atctctttat   2146560
aagatttgcc catcagacaa aatagaacga tttgaaggcg tttatgatat ttagctgtac   2146620
gagagtcttt taaaagtgtt ttgatggttt ggatttcttc tttagttgat ttcatatcac   2146680
tgttatataa tactttttga ttttagtcta gtattagtaa gcagactcaa accttagaaa   2146740
atcttttgag atcattgaca ggtgtatcga atcctaccac agattcagca cgtctggttt   2146800
tggcagaggc taataaagct tttgcagatg atagtttgac agagcaaggt ttacgtgata   2146860
tcttgcaaac agtcaaagat gccattgctt ccctagagtc cattaaggaa agccagtcag   2146920
caactaagga tggaggacaa acagcgggca aagaaacagc aggagaagat gagtctgcaa   2146980
atcaaactca agaaattagc caaggaatta agtaaacttc ttaaagactc aaaccttgaa   2147040
acagtagata aggatgtcct tgaaaactct caaaaagaac ttcaaaaagc agttttgttc   2147100
ttggcagatg aaaaaggctc tgagcatact gcagcagagt tgattgataa tcttaaagag   2147160
gttattgcta agttgaaagc aaacgcctaa taacatatta aaaatctcca gattaggaac   2147220
tatcgctgag ttccctagtc tggagatttt tcagtatacc ccgttgttgg atgcttataa   2147280
cagagtgacg ccatcactgg gctaatagag ataaaataaa caattgattt aggacatttg   2147340
tttgatagtg gtgataaagt tttaaatctg ctacataatt tgtggagttt tttctataat   2147400
taggagttta acctaacctg caaataggag tatactaata atgtaatcgt tatcaaaagt   2147460
ctaaaaaaga atttttagat ggatatcaaa ataaaaaggg aggaaattat gaaaaagttt   2147520
tcaaaaacat tgagagacaa ctggatcttt ctcttgatgg ttttgccagg ggcactctgg   2147580
ttgattctat tcttttacat tccagtattt gggaacgtgg ttgccttcaa agactaccac   2147640
atgaccagta atggtttcat agatagtatc ataaatagta aatgggtcgg actcgataat   2147700
tttagattct tatttagttc aagagacgcc tttattatca cacgaaatac tgtcctctac   2147760
aatcttggct ttatctttct aggtttagtt gtatctgtag ggattgccat tatcctcagc   2147820
gagctccgtt ctaagagaat ggtgaagatt tttcaaactt ctatgttgtt cccttacttc   2147880
ttgtcttggg ttatcatcag tttctttaca gatgccttcc taaatattga taaaggggtg   2147940
ttcaatcatc tattggaaag tcttggtctc aaagaagtca atttctacgc tgacctgggc   2148000
atctggccct atctcctact tttcctaggt atttggaaag gctttggata tagcagtgtc   2148060
atgtactatg cgacgatcat gggaattgat ccaacctact acgaagcagc gacagtggac   2148120
ggagctagca agtggcaacg tattcgcaac gtaaccattc ctcagttgac tccgcttgta   2148180
actgtattga ccatccttgc agtcggaaat atcttccgcg cagacttcgg tctcttctat   2148240
caaatcccac acaatgctgg tcagctttac aatgtaacca acgttttgga cgtatatgtc   2148300
tttaatggtt tgactcagac agcagatatc ggtatggctg cagcagccgg tctttaccaa   2148360
tccgttgttg gtttgattct ggttatccta tcaaacttgc ttgcaagacg agtcgatcca   2148420
aactcagctt tgttctagaa aggaggagaa tatggcaaaa aagaaaatta aaaaagaaaa   2148480
aattgataat gtcggcattc actccttcag taagaaagca gatatcttct tcagtatcat   2148540
ttcgggtttg attgccctct cttgtatcct accttttgta ttcgttatca ttatttcagt   2148600
gacagacgag aaaagcctcc tccaatacgg ctatagcttc ttcccatccc aatttggctt   2148660
agacggtttt gagtttttgg cacagtttaa ggataaaatc ctacaagccc tcttcatctc   2148720
tgtctttgta accgtagttg ggacattgac aaatgtcttt atcacaacaa cctatgccta   2148780
cgctatttca cggacaacct ttaagtatcg cagattcttt accatcttcg tccttctcag   2148840
tatgttgttc aacgctggtt tggtaccagg ttatatcatg gtgacccgtg tacttcagct   2148900
tggtgacact gtttgggcct tgattgttcc aatgcttctc tcaccattta acatcatctt   2148960
gatgcgttcc ttcttcaaga agaccattcc agaagccatt ctagaatcgg ctcgtatcga   2149020
tggtgccagt gaggcccgga ttttcttcca aatctgtttg ccattgtcac taccaggtat   2149080
cgcaaccatc acgctcttaa cagctcttgg tttctggaat gactggttca acgcccttct   2149140
ttacatcaag agtgacaact tgtatccatt gcaatatttg ctcatgcaaa tccaacaaaa   2149200
tatggactac attgccaaag cggtcggctt gattggtcaa ctgggagttg ctctaccgaa   2149260
agaaacaggt cgtatggcca tggttgtggt tgcaaccctt ccaatcgcga ttttgtatcc   2149320
atttttccaa cgctactttg taaaaggttt gactatcggt ggtgtgaaag aatagtgctt   2149380
attgagaaat aacatttctc agttcccaac ttcccttgtg tgaagttaat actcttcgaa   2149440
aatcaaattc aaaccgcgtc aacgtcgcct tgccgtagat atatgtaact gacttcgtca   2149500
gtcttatcta caacctcaaa gcagtgcttt gagcagcctg cggctagttt tctagtttgc   2149560
tctttgattt ttattgagta taagatcatt acattgttta taagtttaaa aataaaaaaa   2149620
ggagttttta tcatgaaaaa ctggaaaaaa tatgcttttg catctgctag tgtagtcgct   2149680
ctggctgcag gtcttgctgc ttgtggaaat ttgacaggta acagcaaaaa agctgctgat   2149740
tcaggtgaca aacctgttat caaaatgtac caaatcggtg acaaaccaga caacttggat   2149800
gaattgttag caaatgccaa caaaatcatt gaagaaaaag ttggtgccaa attggatatc   2149860
caataccttg gctggggtga ctatggtaag aaaatgtcag ttatcacatc atctggtgaa   2149920
aactatgata ttgcctttgc agataactat attgtaaatg ctcaaaaagg tgcttacgct   2149980
gacttgacag aattgtacaa aaaagaaggt aaagaccttt acaaagcact tgacccagct   2150040
tacatcaagg gtaatactgt aaatggtaag atttacgctg ttccagttgc agccaacgtt   2150100
gcatcatctc aaaactttgc cttcaacgga actctccttg ctaaatatgg tatcgatatt   2150160
tcaggtgtta cttcttacga aactcttgag ccagtcttga aacaaatcaa agaaaaagct   2150220
ccagacgtag taccatttgc tattggtaaa gttttcatcc catctgataa ttttgactac   2150280
ccagtagcaa acggtcttcc attcgttatc gaccttgaag gcgatactac taaagttgta   2150340
aaccgttacg aagtgcctcg tttcaaagaa cacttgaaga ctcttcacaa attctatgaa   2150400
gctggctaca ttccaaaaga cgtcgcaaca agcgatactt cctttgacct tcaacaagat   2150460
acttggttcg ttcgtgaaga aacagtagga ccagctgact acggtaacag cttgctttca   2150520
cgtgttgcca acaaagatat ccaaatcaaa ccaattacta acttcatcaa gaaaaaccaa   2150580
acaacacaag ttgctaactt tgtcatctca aacaactcta agaacaaaga aaaatcaatg   2150640
gaaatcttga acctcttgaa tacgaaccca gaactcttga acggtcttgt ttacggtcca   2150700
gaaggcaaga actgggaaaa aattgaaggt aaagaaaacc gtgttcgcgt tcttgatggc   2150760
tacaaaggaa acactcacat gggtggatgg aacactggta acaactggat cctttacatc   2150820
aacgaaaacg ttacagacca acaaatcgaa aattctaaga aagaattggc agaagctaaa   2150880
gaatctccag cgcttggatt tatcttcaat actgacaatg tgaaatctga aatctcagct   2150940
attgctaaca caatgcaaca atttgataca gctatcaaca ctggtactgt agacccagat   2151000
aaagcgattc cagaattgat ggaaaaattg aaatctgaag gtgcctacga aaaagtattg   2151060
aacgaaatgc aaaaacaata cgatgaattc ttgaaaaaca aaaaataatc agctaaattg   2151120
atttcgtgta ttcattccta actcctaaaa taagaatcac tgctttcctc aggttggtct   2151180
ggggagggca gtggtttttt tggcacaagg atatagatat ccatgttttc tcttgtcctt   2151240
attttaacca ttcaagaaat ttcgagaacc ctctacaatt tccagtcaaa taaattgcat   2151300
tcgttttctc aagcaggtat actagtgtag ataaataaaa aatttagaaa atttaagaat   2151360
agaaaagaga acaaatctta tggcaaaaga tattcgtgtc ttactttact acctttatac   2151420
tccaattgaa aatgcagagc aatttgctgc agaccacttg gctttctgta aatcaatcgg   2151480
ccttaaaggc cgtatcctag tcgctgacga gggaattaac ggaacagttt caggtgacta   2151540
tgaaacaact caaaaataca tggactacgt tcacagcctt ccaggaatgg aagaactctg   2151600
gttcaagatt gacgaagaaa atgaacaagc cttcaagaag atgtttgttc gctacaagaa   2151660
agaaattgtc caccttggtt tggaagacaa cgactttgac aatgacatca acccacttga   2151720
aacaacaggt gcttacttgt ctccaaaaga gttcaaagaa gcgcttcttg ataaagatac   2151780
cgttgtcctt gacacacgta acgattatga gtacgaccta ggacatttcc gtggagctat   2151840
tcgcccagat attcgcaact tccgtgagtt accacaatgg gtccgtgata acaaggaaaa   2151900
attcatggac aagcgtgtcg tggtttactg tacaggtggc gttcgctgtg agaaattctc   2151960
aggctggatg gtccgtgaag gctacaaaga tgtcggccaa ttgcacggag gaatcgcaac   2152020
ttacggtaaa gacccagaag ttcaaggtga gctttgggat gggaaaatgt acgtctttga   2152080
cgagcgtatt gccgttgatg tcaaccatgt caacccaact atcgtaggga aagactggtt   2152140
tgatggaaca ccatgtgaac gttatgtcaa ctgtggaaat ccattctgta accgtcgtat   2152200
cttgacatca gaagaaaatg aagacaagta ccttcgtgga tgctcacacg agtgccgtgt   2152260
tcacccacgt aaccgctatg tttcaaaaaa tgaattgaca caagctgaag ttatcgagcg   2152320
cctagccgct atcggtgaaa gcttggatca agcagctact gtataagatc aaacagtcct   2152380
caggggctgt ttttctatgc tttgtactca aaaatctaat actcaatgaa aatcaaagag   2152440
caaactagga agctagctgc aggctgctca aagcactgct ttgaggttgt agataagact   2152500
gacgaagtca gttacatata tctacggcaa ggcgaagctg acgcggtttg aagagatttt   2152560
cgaagagtat aaagtttgtt tttgtatctt tcagaaaaat aaggtatact gtatgtaaac   2152620
gatttcaaag gagtccagtt atggcgaaaa cattttttat tccaaataaa cagagcattt   2152680
taggagaaca agagattttg aatgccaagt cgatcttggc cttgctagac ggtttggagt   2152740
cacatagcta tgatgtagtc tatctccgtc agcctcttaa tcgtctcgaa tatatcgagt   2152800
gtgcgatagt ggggcaatca caatttctct ttaaggtcag ttatgctgat ggtcaaaagg   2152860
cttaccgtgt cgatcttcct gacctactaa caaagacaga ctggcagatt atcaagtcat   2152920
ttttagatgc tttgcttgct tatacaggga ctgatattga agggctagat ggttttgatt   2152980
ttgaagctta tttccaagca agtattcaag cctatctagc agaccctgta gctcgtttta   2153040
cgatttgcca aggaattttt aatcctattt tctttagtcg tgagaacttg aaaagctttt   2153100
tagaggcaga tggcttggct cagtttgaag cgcgtgtgcg tgcggttcaa gagacagatg   2153160
cctactttgc gagagtttcc ttctatcagg atggagaagg aaaagtgcat ggcgtttacc   2153220
atctagctca aggagtcaag acagttttac cgagagaacc gtttgttcct gcagcctata   2153280
ttgagcaatt ggtggataag gaagtccagt gggagattga cttggttcaa atcacaggag   2153340
atggctctaa accagaagac tatgaagcca ttgctcgctt ggactatgca aaattcttag   2153400
aggtattacc cccatctttt taccaccaac tagacgccaa tcaaatagaa gtgcaaccca   2153460
tattagacaa agattttaaa acattagcac aagaaaagta aagcagaagc aggtcaatcg   2153520
acttgctttt ttgacataga aaaaatcctg ccaaggatga caggattgct actcaatgaa   2153580
aatcaaagag caaactagga agctagccgc aggctgtact tgagtacggt aaggcgaagc   2153640
tgacgtggtt tgaatttgat ttttgaagag tatgaagttt aaagaaaggc caagatacga   2153700
agataatctc caatcagtgc cacttcagct acaaagaaga ggaggataat aactccgttc   2153760
acaaggacag acaagaataa ttgatagaag gagtcggttt cacttgcttg acttggtctt   2153820
gtaatgatat ggagactggc aagcagaatg attccaatgc taatcacaca caagagggct   2153880
gtaaatcgta ggctatcaaa gaaagcaaag aaactagcaa tagcagtgag gaagattgga   2153940
attgccaaga gttgactata ttgttggaga accttgtcta gcgtccagtc cttttcctgg   2154000
tggataaatc gtctcacaac gaaactaccc aagaggaatg aaaagaagaa gagtgttgtc   2154060
gctactagga tagagatgat agaaaaaaga gttaaaggag ctagctgctc agggaagcga   2154120
ctgttaatgc ttgctatatg tccatagtaa gcatgtttga tgtgatagat actaaagaaa   2154180
aaggaagatg cagaaaacag aatgagcaag agaaaggctg tgtaactgtg tgtgatactt   2154240
gtttccaact tacttgtagg agatttgatc gcttccacta gccaagacca aaaatcaagc   2154300
acttgctctt tccatttatc cctagatttt ggagcttggt cggggatata aggactttct   2154360
aaagatttac tgataagaag tggctctttc gtggttgctt tttgctgagg aagagcttct   2154420
tggctctctt cagctatagt gactttttct gtttctttag aaaggtctgg ctcttcttca   2154480
gtagaattag atgccttctt ttcttctatt tctgttctcg cttcactgtc ttcaggagct   2154540
tcaattttct cttcttgctg gctttccaat tcgacttcag cttgagggac ttcctcctct   2154600
aactgagtat ttttttcaat tggtgtatcg agatcggcta tcgtttcttc agccttgtct   2154660
gcaacctctt gagcttgctc ttcaggcttg ttcttgcttg ttgtttttac aaaatcatta   2154720
ctttcaaacc attcttgttt catggtagaa cctccttttt agttagataa atatgtttcc   2154780
atagtagcaa atgtaagcgt ttttgtcaac gtctgcttgg tgtggatatt agatcaatat   2154840
tatcatcaga tctcgcaatg agttgatcct tgacatcggt tttttcagtt ttgtaagggt   2154900
tgcttaattc cgtacctctt gattcaggct tttctcttgt gaattggaag atagaaccat   2154960
agttgcttga gatgtcccag ttaattcgtt ggctttcttt ctggtctagg atgattctga   2155020
gataatcttt ggcagtcagt tcaaccttgc catggacttg gatattttca gcgtggaagt   2155080
gattctctgt tgactctagc tgactatctg taagaactgt atcaaagata ttaacgatat   2155140
tgggcgttgt gagtttactg tttttgatac gacttccttc aattcggagg atatagctgt   2155200
ttgtattgag ggtcgcattt tcaaggctag catttatgat ggtggtttgt ccgcgattgg   2155260
ctgagatgtt gatccctttt agagttctcc cttttggtag tcggagaata acttcttcaa   2155320
aacgactaga gtagctactt gcgatatgaa gaatcccacc aattccagaa gagagaaacg   2155380
gagtttcaga cagtttctta tcagtgagac tcagagttct atcgttctga ttggtgataa   2155440
gatcatggtg agcagaaaga gatggatggt aagaaatgtg gatttgatca tcgaaagagt   2155500
ctgtgatggt gagcgtgtgt tggtggagag taatttctag gttttcgact tccttgccaa   2155560
aggttagctt ttccgtacgg ctatcataga caggttcttt ggacatggaa agtaggctct   2155620
taatcccgtc agattggata cctacaaaaa gcaggataaa gccgataacg gtagtcacca   2155680
caccaaagat gagaaatcct tttgtccatt tacgcatgct gattacctct ctttcctttt   2155740
ttaagaacaa attgtaccag acgaacaatg agtagaccga agaagcgagt tgcataggaa   2155800
atgccaagta aaactagcga agaagcaccg atagccagta aaccagaacc aaaaatcaag   2155860
ataaaggctg atttggcttg ggcgaggaca gtgaaacttt caactaaaaa taggaatccg   2155920
ccgatgatac ccagtatgga aactgcaaag aaagccagaa tgacagtcaa agcggctaca   2155980
agaattgcga acagggtcac gaggatggcg attcccagag gaatgccgat aggtgctgca   2156040
aggagggcta acaaggcgat atgtaaaatt tgtcggttat ttttttgagc gggtgcttca   2156100
ttgatttttt tatcgagaag attggataga acttcgtggg ccgcttcttt gggagttccc   2156160
aaactagcga tgagttcttc ttctccttcg actccagcat cgtcaaagag ctctctgaaa   2156220
tagtccatgg cttcgatacg gtcagcttca ggtagtttct tgagatagag ttctagctga   2156280
gtcaggtatt cagttcttgt catggcggat actcccttct atgatgccat tgatggtgtc   2156340
tgtatagagt gcccattcat cttttagggt caagagctgc tctataccac cgtttgtcaa   2156400
ggagtagtat ttgcgcatgc gaccttggaa ctctctagaa taggttgtca gaaagctatt   2156460
gccttccaat tttttgagaa tgggatagag tgtggattct ttgatattag cgatcagctt   2156520
aatggtttgg ctaatctcat aaccataaga atcaccctgc tccagtacag ccaagatgag   2156580
aaattcaatc aaggcagagg atgttggaaa gtacatggga aacctccttt tctaatgtgt   2156640
aagattttta tatataattt ttctacacat acattgtaca tctaaaagaa agccctgtca   2156700
agagaaatgt gtaaaatttt tatatataaa aaacttctag ctaaaactag aagtttaaag   2156760
gatcttatcc gctctgtcca ctgtaaagag ggccacagtc atcaggatat cgatgagcaa   2156820
gagggcagct acagatggta cccaagagtg gaacaggtca aaactgtaac caaagagggt   2156880
tggcccaaag gctgctagga tatagcctcc tgtttgagat aggccggaca attgggctgt   2156940
cttttcaggg gcgcttgtct tgagtgaaaa gttgaccatg agataaggga agagggcact   2157000
ggttgcggtt ccgatgagga gatggatggc aagccagtaa atgaaattat tgattgggaa   2157060
aaagagcatg gaaatgccga ccacaccagc tagtgaaacc agagtgagca tgagctgacg   2157120
gttgcgagta gataaactgg ttgtcaggct tgggatggtc attgaaaaag gaatgctaat   2157180
cagagataag atagaagtca gcaagccagc ttcgtgactg gatagacctg catggataga   2157240
catggtaggt aaccaggtca tgacggtgta aaagatcaag gattgaaaac ctgaaaagat   2157300
aataattgcc caaacctgtt tattacgcat gacctttatt tgactttttt gtttggtttg   2157360
tggagctagt ctatgattat agcggtgatt tgggagccag accaaaaaag ttgctagaca   2157420
gagtaacgtg aggagaagga taagtccttt ccaagaactg gcttgtgtaa tgggcacagc   2157480
tagataggaa gccagagccg ttgcaatccc catagacgtt acatataagg tggtcagaaa   2157540
accaattttc tttggttgat tggcttggat aagactagga agcaggacat tgatgactgc   2157600
gacacttgcc ccaaccatca aggttcctag atagagcagg ggcagattga ttagtcgaat   2157660
aagtgagccg atggtcaaga agaagaggct gtaggtgaag agatgctcca agccgatttt   2157720
ctgagccagt tgggtagaaa atggtgaaaa gagggtaaac ataaggagag gcaggctggt   2157780
caagacacca agcgaactaa cttctacctc cagaccttgc gaaatatttc ccaaaataat   2157840
gggtaaaaca gtaaaaggag ttcgcaagga aacaccaatc aggataatac ctggaacaaa   2157900
aaagagtgat tgctttttca tataatacct cttctagctg attttaataa cagcttattt   2157960
taaggctttt tcactataat gtcaagtaag gtttctggct ttcaagataa aaatgggaaa   2158020
gtcttgaaaa ttatgataga atggtggaag gaaaaattca ggagagtagt agtgactcaa   2158080
aatgttgaaa gtcttctcgt atccattgta atcagtgcat acaatgaaga aaaatatctg   2158140
cctggtctaa ttgaagactt aaaaaatcaa acctatccta aagaggatat tgaaattcta   2158200
tttataaatg ctatgtccac agatgggacc acagctatca ttcagcaatt tataaaggaa   2158260
gatacagagt ttaactcaat tagattgtat aacaatccta agaaaaatca agctagtggt   2158320
tttaacctgg gagttaaaca ttctgtaggg gaccttattt taaaaattga tgctcattca   2158380
aaagttactg agacttttgt aatgaacaat gtggctatta ttcaacaagg tgaatttgtc   2158440
tgtggggggc ctagaccgac gattgtcgaa ggaaaaggaa aatgggcaga gaccttgcat   2158500
cttgttgagg aaaatatgtt tggcagtagc attgccaatt atcgaaatag ttctgaggat   2158560
agatatgttt cttctatttt tcatggaatg tataaacgag aggttttcca gaaggttggt   2158620
ttagtaaatg agcaacttgg ccgaactgaa gataatgata ttcattatag aattcgagaa   2158680
tatggttata aaatccgcta tagcccaagt attctatctt atcagtatat tcgaccaaca   2158740
ttcaagaaaa tgctgcatca aaagtattca aatggtttgt ggattggctt gacaagtcat   2158800
gttcagttta agtgtttatc attatttcac tatgttcctt gtttatttgt tttgagtctt   2158860
gtgtttagtc tagcattgtt accgatcaca ttcgtattca taactttact attaggtgcc   2158920
tattttctac ttttgtcatt actcactttg ctgactttat taaaacataa aaatggattt   2158980
ctaattgtga tgccctttat tttattttcc attcactttg cttatggcct tgggacgatt   2159040
gtaggtttaa ttagaggatt taaatggaag aaggagtaca agagaacaat aatttatttg   2159100
gataaaataa gccaaataaa tcaaaatatg ctataataac aatatagtaa aactctttta   2159160
aggaggagta gatttctatg aataaaaaac taacagatta tgtgattgat ctggtggaaa   2159220
ttttaaataa acaacaaaag caggttttct ggggaatatt tgatattttc agtatggtgg   2159280
tttccatcat tgtatcttat attttatttt atgggctgat taatccagca cctgttgact   2159340
acattatcta tacgagtttg gccttcctgt tctatcaatt gatgattggt ttttgggggt   2159400
tgaacgcgag cattagtcgt tacagcaaga ttacggattt catgaaaatc ttttttggtg   2159460
tgactgctag cagtgtcttg tcatatagta tctgttatgc cttcttgcca ctcttctcca   2159520
tccgtttcat cattctcttt atcttgttga gtaccttctt gattttattg ccacggatta   2159580
cttggcagtt aatctactcc agacgcaaaa aaggtagtgg tgatggagaa caccgtcgga   2159640
ccttcttgat tggtgccggt gatggtgggg ctctttttat ggatagttac caacatccaa   2159700
ccagtgaatt agaactggtc ggtattttgg ataaggattc taagaaaaag ggtcaaaaac   2159760
ttggtggtat tcctgttttg ggctcttatg acaatctgcc tgaattagcc aaacgccatc   2159820
aaatcgagcg tgtcatcgtt gcgattccgt cgctggatcc gtcagaatat gagcgtatct   2159880
tgcagatgtg taataagctg ggtgtcaaat gttacaagat gcctaaggtt gaaactgttg   2159940
ttcagggcct tcaccaagca ggtactggct tccaaaaaat tgatattacg gaccttttgg   2160000
gtcgtcagga aatccgtctt gacgaatcgc gtctgggtgc agaactgaca ggtaagacca   2160060
tcttagtcac aggagctgga ggttcaatcg gttctgaaat ctgtcgtcaa gttagtcgct   2160120
tcaatcctga acgcattgtc ttgctcggtc atggggaaaa ctcaatctac cttgtttatc   2160180
atgaattgat tcgtaagttc caagggattg attatgtacc tgtgattgcg gacattcaag   2160240
actatgatcg tttgttgcaa gtctttgagc agtacaaacc tgctattgtt tatcatgcgg   2160300
cagcccacaa gcatgttcct atgatggagc gcaatccaaa agaagccttc aaaaacaata   2160360
tccgtggaac ttacaatgtt gctaaggctg ttgatgaagc taaagtgtct aagatggtta   2160420
tgatttcgac agataaggca gtcaatccac caaatgttat gggagcaacc aagcgcgtgg   2160480
cggagttgat tgtcactggc tttaaccaac gtagccaatc aacctactgt gcagttcgtt   2160540
ttgggaatgt tcttggtagc cgtggtagtg tcattccagt ctttgaacgt cagattgctg   2160600
aaggtgggcc tgtaacggtg acagacttcc gtatgacccg ttactttatg accattccag   2160660
aagctagccg tctggttatc catgctggtg cttatgccaa agatggggaa gtctttatcc   2160720
ttgatatggg caaaccagtc aagatttatg acttggccaa gaagatggtg cttctaagtg   2160780
gccacactga aagtgaaatt ccaatcgttg aagttggaat ccgcccaggt gaaaaactct   2160840
acgaagaact cttggtatca accgaactcg ttgataatca agttatggat aagattttcg   2160900
ttggtaaggt taatgtcatg cctttagaat ccatcaatca aaagattgga gagttccgca   2160960
ctctcagtgg agatgagttg aagcaagcta ttatcgcctt tgctaatcaa acaacccaca   2161020
ttgaataaaa aagaaaaacg catagtatca agttacacaa ccttggtaat atgcgtttta   2161080
ttatgtagag acttatactc ttcgaaaatc tcttcaaacc acgtcaacgt cgccttgccg   2161140
tatatggtta ctgacttcgt cagttctatc cacaacctca aaacagtgtt ttgagctgac   2161200
ttcgtcagtt ctatccacaa cctcaaaaca gtgttttgag ctgacttcgt cagttctatc   2161260
cacaacctca aaacagtgtt ttgagctgac ttcgtcagtt ccatccacaa ccttaaaaca   2161320
gtgttttgag ctgacttcgt cagttccatc tacaacctta aaacagtgtt ttgagctgcc   2161380
cgcagctagt ttcctagttt gctctttgat tttcattgag tattacttca ttttcttctg   2161440
aaatggaatt gttacccagt ctatgctatt gaaaatacgc caaaacttct aagggtttgt   2161500
gagcgatata atcaggttga tagtttagta gatctgcttg ctctccaaat ccccaagtga   2161560
tggccaattt ctgaatacct gtttctcgag ctcccagcat atcaaacttg gtatctccga   2161620
tgatgatggc ttgttctggt gctagttgat gtgtctgcaa ggcttggtga atgacatctg   2161680
ccttatgggg tgcttcaggg ctagaaccat aaatgccatc aaagaaatga tggatttcca   2161740
agttttttgc catgtcttga gcagtagatg tatcctttgt cgtggtgatg tagagtggat   2161800
aactgctcga taactcctca agcaagtcta taatctgagg aaagagttga gcttcataga   2161860
tgccttttgc cttatagtaa gaacgatata tctgcacggc ttcagaaatt tggtctttgg   2161920
acaggcaggt cgcaaaacta ctttcgagag gtggtcccat aaaaccacga atagttttgg   2161980
catcagggct aggcaccccc agctctttaa aggtataggt aaaggcattg tgaatcccga   2162040
tagaactatc aacgagggtt ccatccaaat cgaaaaaaat cgctgtgata gaggtcatgg   2162100
tttctcctat ttgataagct tattctccga aaatttcttt ttggaggcga cgaccagtag   2162160
gggtggtagc gagtccacct tcagctgttt cacgaaaggc agttggcatg cttgctccta   2162220
cttggtacat ggcatcgatc acttcatcca cagggatttt agattcgata cctgccaagg   2162280
ccatgtctgc tgcgatgaaa gcaaagctag ctcccatggc attacgtttg acacagggaa   2162340
cttcgaccaa acctgcaaca gggtcacaga tgaggcctag catattttta atgacaaagg   2162400
caatagcttg actggcctga taaggtgttc cacctgcagc cagagtcaag gcggcagcac   2162460
tcatagcaga ggctgaacca acttcagctt gacacccacc ctcagcacct gagatggagg   2162520
cattgtttgc gatgactagt ccaaaggcac cagcagcaaa gaggaaatcc aattgttgct   2162580
cgtggctgag gcctaatt                                                 2162598

